Drug Information Sheet ("Kusuri-no-Shiori")
620006946
Revised: 06/2011
Information is based on approvals granted in Japan. In some cases, the approved details may vary in countries
other than Japan.
In deciding to use a medicine, the risk (side effects) of taking the medicine must be weighed against the benefit(effects) it will do. The patient's cooperation is indispensable here.

Brand name： SUPACAL TABLETS 40mg
Active ingredient： Trepibutone
Dosage form：white to yellowish white tablet (φ: 7.6 mm, thickness: 2.9 mm)
Printings on wrapping： スパカール 40mg, OH-251, 40mg, Supacal 40mg
Effects of this medicine
This medicine promotes secretion of the bile and pancreatic juice, and accelerates flaccidity of thesmooth muscle in the gastrointestinal tract (sphincter of hepatopancreatic ampulla etc.) to lower
internal pressure of the gallbladder and bile duct. It improves the symptoms of the bile duct andpancreatic disease.
It is usually used for improvement of cramp and bile secretion associated with cholelithiasis,cholecystitis, cholangitis, dyskinesia of the biliary tract or postcholecystectomy syndrome, or pain andgastrointestinal symptoms associated with chronic pancreatitis.
Before using this medicine, tell your doctor/pharmacist
・ If you ever experienced any allergic reaction (itch, rash etc.) to any medicine.
・ If you are pregnant or breastfeeding.
・ If you are using any other prescription or nonprescription (OTC) medicine. (It is important to reduce
the risk of drug interactions.)
Dosage regimen (proper use of this medicine)・ Your dosage regimen is:≪:order of your doctor≫
・ General dosage regimen: For adults, take 1 tablet (40 mg of the active ingredient) at a time, 3 times
daily, immediately after meal. However, the dosage may be adjusted according to the diseases, ageor symptoms. Strictly follow the instructions of your doctor/pharmacist.
・ Missed dose: Take a dose as soon as possible when you remember that you missed a dose. However,
if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule.
DO NOT take double doses to make up for the missed dose.
・ Overdose: If you took too much of the medicine (more than ordered), check with yourdoctor/pharmacist.
・ Others: Do not stop taking the medicine without the instructions of your doctor.
Precautions while using this medicine
Side effects of this medicine
Common side effects are reported as below. If any of them occurs, check with your doctor/pharmacist:
nausea, constipation, abdominal bloating, diarrhea, rash, itch, etc.
In rare cases, symptoms described below may be the sign of side effects indicated in brackets [ ]. If
they occur, stop taking your medicine and check with your doctor immediately.
No pertinent entries.
Other side effects not listed here may occur. Check with your doctor/pharmacist if you have any
worrisome symptom.
Storage and other information
・ Keep the medicine out of the reach of children. Store it away from direct sunlight, heat andmoisture.
・ Discard the remainder. Do not store them.
For doctor use only: DayMonthYear

For further information, ask your doctor/pharmacist. Japanese package insert information (for medicalprofessionals) is available on the website of Pharmaceuticals and Medical Devices Agency.
SIE①