Tokyo Metropolitan
Institute of Medical Science,
19th International Symposium
February 8, 2019TOKYO JAPANChairs:
Yuji Okazaki, M.D. & Makoto Arai, Ph.D. & Masanari Itokawa, M.D, Ph.D.
Location:
Tokyo Metropolitan Institute of Medical Science,
2-1-6 Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan

Preventive medical research in areas of psychiatry, health, and social welfare:
Beneficial life course intervention in critical and sensitive periods for glycation,oxidative stress, and nutritional epidemiology
A life course approach is essential to understand population health and disease. It isestablished that an individual’s health is strongly influenced by multiple genetic andenvironmental factors. Attempts to understand the molecular mechanisms underlying physicaland mental health based on a life course trajectory are ongoing. Recently, specialists have revealed
that advanced glycation end products (AGEs), and oxidative stress (OS) are closely associatedwith psychotic and systemic dysfunction. AGEs and OS have extremely diverse structures andare critical to many biological processes. However, these modifications appear, disappear, andundergo dynamic structural changes during aging and the development of various disease
pathologies, making them very difficult to accurately characterise.
In this symposium, we discuss the trajectory of AGEs/OS information, adolescentdevelopment, and nutritional epidemiology, and how multifaceted technical approaches
combining genetics, biology, chemistry, nutrition, and bioinformatics, can be used to accurately
characterise spatiotemporal changes during each life stage. We hope that these data will provide
information that may elucidate novel genetic and environmental factors involved in psychiatricand physical disorders in each life stage. Advancements made using glycated/oxidative marker
data will highlight the molecular mechanisms underlying recovery from these disorders.

1Schedule and Speakers
Update: 1/Feb/2019

Chairs:Yoji Okazaki, M.D. & Makoto Arai, Ph.D. & Masanari Itokawa, M.D, Ph.D.
Opening remarks
・9:00- Director

Dr. Hisao Masai, Ph.D.

(Tokyo Metropolitan Institute of Medical Science)
Opening:・9:10- Makoto Arai, Ph.D. & Masanari Itokawa, M.D, Ph.D.

Session I: Health and well-being & Nutritional Epidemiology
・9:20- Dr. Marcus Richards, Ph.D.
(MRC Unit for Lifelong Health and Ageing at UCL, University College London)

Title: Life course determinants and trajectories of mental health and wellbeing; a general
population perspective
・9:50- Dr. Satoshi Sasaki, M.D., Ph.D.
(Department of Social and Preventive Epidemiology, School of Public Health, The University ofTokyo)

Title: Nutritional epidemiology: gap between the roles and the methodological ability
Session II: Technology & Food Science & Disease (1)・10:30- Dr. Paul J Thornalley, Ph.D.
(Diabetes Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin KhalifaUniversity)

Title: Metabolic drivers of dicarbonyl stress and oxidative stress in diabetes and aging
・11:00- Dr. Ryoji Nagai, Ph.D.
(Department of Bioscience, School of Agriculture, Tokai University)

Title: Advantages of both simple and precise analysis of AGEs for evaluating metabolicdisorders
2・11:30- Dr. Frédéric J. Tessier, Ph.D.
(University Lille, Inserm, CHU Lille, U995-LIRIC-Lille Inflammation Research InternationalCenter)

Title: Dietary Advanced Glycation End Products and Health・12:00- Dr. Norma Frizzell, Ph.D.
（Department of Pharmacology, Physiology & Neuroscience, School of Medicine, University ofSouth Carolina）

Title: Fumarate Derived Metabolic Stress Exacerbates Mitochondrial ATP Deficiency in
Leigh SyndromeLunch
・12:40 – 13:40

Session III: Technology & Food Science & Disease (2)・13:50- Dr. Akira Monji, MD, PhD.

(Department of Psychiatry, Faculty of Medicine, Saga University)
Title: A role of NADPH (NOX) system in the pathophysiology of neuropsychiatric disorders
・14:20- Dr. Naila Rabbani, Ph.D.
(Clinical Sciences Research Laboratories, University of Warwick)

Title: Advanced glycation end products, dityrosine & arginine transporter dysfunction inautism - biomarkers for clinical diagnosis
・14:50- Dr. Moeko Shinohara, MD, PhD(Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School ofMedical Sciences)

Title:

Blood vitamin C levels are associated with reduction of Apolipoprotein E E4-relatedrisks of cognitive decline in women: The Nakajima study
・15:20- Dr. Chih-Kang Chiang, MD, PhD.
(Graduate Institute of Toxicology, National Taiwan University College of Medicine)

Title: The double-edged sword of endoplasmic reticulum stress in uremic sarcopenia throughmyogenesis perturbation.
3Coffee & Tea Break, 20 min
・16:10- Dr. Reiko Inagi, Ph.D.
(Division of CKD Pathophysiology, The University of Tokyo, Graduate School of Medicine,Tokyo)

Title: Oxidative/glycative stress, a culprit of organelle stress, in kidney disease
・16:40- Dr. Ram H. Nagaraj, Ph.D.
（Department of Ophthalmology, University of Colorado School of Medicine）

Title: AGEs in extracellular matrix promote fibrosis
・17:10- Dr. Monika Pischetsrieder, Ph.D.
(University of Erlangen-Nuremberg, Department of Chemistry and Pharmacy, Food Chemistry)

Title: Possible interaction of food components with glycative and oxidative protein damage
in vivo
・17:40- Dr. Yasuhiko Yamamoto, MD, PhD.
(Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate
School of Medical Sciences)
Title: Pattern-recognition receptor RAGE in health and disease

Closing:・18:10- Drs. Yoji Okazaki, M.D. & Makoto Arai, Ph.D. & Masanari Itokawa, M.D, Ph.D.

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