Final Evaluation Report | Global Station for Quantum Medical Science and Engineering, GI-CoRE, Hokkaido University

Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education(GI-CoRE)
Hokkaido University

Final Evaluation Report

北海道大学

国際連携研究教育局

量子医理工学グローバルステーション

外部評価報告書

July 2020

July 2020
2020 年 7 月

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Final Evaluation Report(brief version in Japanese)
外部評価報告書（日本語・概要版）

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もくじ（日本語版）

はじめに •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 5
外部評価委員 ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 7
外部評価委員会実地調査要領••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 8
外部評価調書の概要 ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 9

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はじめに
国際連携研究教育局（GI-CoRE）は、北海道大学の強みや特色を活かした国際連携
研究教育の推進と、部局が独自に進める国際連携研究教育の支援を目的とし、世界トップレベルの教員を国内外及び学内から結集した総長直轄の教員組織です。
GI-CoRE 内には研究領域ごとの活動拠点である「グローバルステーション（GS）」
を置き、各 GS において、原則 5 年間の設置期間内に重点的に研究教育活動を進めています。これまでに、延べ７つの GS（下記※を参照）を設置し、研究活動を推進するとともに、最先端の研究成果を大学院教育などに還元してきました。
GI-CoRE では、GS の設置期間満了を迎える年度に、各 GS でのこれまでの活動を振り返るとともに、今後、より強固かつ持続可能な研究教育体制を確立していくため、
国内外の有識者により構成される外部評価委員会において、評価を実施することとしています。
この外部評価報告書は、2018 年 8 月に実施した量子医理工学 GS の自己点検成果
報告書及び外部評価結果を一冊に収録した、いわば GS の研究教育活動の集大成です。
なお、設置期間を満了した量子医理工学 GS は、関連部局等に定着化し、2020 年
4 月以降も「GI-CoRE 協力拠点」として、GI-CoRE と連携しながら研究教育活動を継続
しています。
本学では、外部評価結果を踏まえ、より充実した研究教育活動を実践していくこと
により、世界の課題解決に貢献していきたいと考えております。

北海道大学 国際連携研究教育局
局長代行（総長代行）
笠 原 正 典※これまでに設置したグローバルステーション（GS）
GS 名

設置期間

主な学内連携部局等（年度）
量子医理工学2014～2019

医学研究院、大学病院ほか

人獣共通感染症

2014～2019

人獣共通感染症リサーチセンター、獣医学研究院

食水土資源

2015～2019

農学研究院ほか

ソフトマター2016～2020

先端生命科学研究院ほか

ビッグデータ・サイバーセキュリティ

2016～2020

情報科学研究院ほか

北極域研究2016～2020

北極域研究センターほか

バイオサーフィス創薬

2019～2023

薬学研究院ほか

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国際連携研究教育局(GI-CoRE)
量子医理工学グローバルステーション
外部評価委員

大阪大学 小川 和彦 教授
ペンシルベニア大学 コンスタンティノス・コーメニス 教授
北京大学第一医院 シンスゥ・グァオ 教授
委員長


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国際連携研究教育局(GI-CoRE)
量子医理工学グローバルステーション
外部評価委員会実地調査要領

１．調査日程平成 30（2018）年 8 月 8 日（水）２．詳細スケジュール
時刻

次第

15:00～

名和 GI-CoRE 局長挨拶・趣旨説明

15:10～

関係教員ヒアリング①（全体像説明）
白土博樹 GS 長からの概要説明
Quynh-Thu Le 招へい教員からの補足説明

15:35～

関係教員ヒアリング②（臨床科学部門）
清水伸一教授・Khin Khin Tha 特任講師からの概要説明
Daniel Chang 招へい教員からの補足説明

15:55～

関係教員ヒアリング③（医学物理部門）
梅垣菊男教授・松浦妙子准教授・宮本直樹准教授からの概要説明
Lei Xing 招へい教員からの補足説明

16:15～

関係教員ヒアリング④（放射線生物部門）
Jin-Min Nam 講師からの概要説明
Amato Giaccia 招へい教員からの補足説明

16:35～

全体に係る質疑応答

17:00～

評価委員の打合せ

17:30～

講評（～17:50 閉会）

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国際連携研究教育局(GI-CoRE)
量子医理工学グローバルステーション
外部評価調書の概要（参考和訳）

総合評価：Ｓ（評価コメント）
量子医理工学グローバルステーション（GSQ）は、世界のさまざまな課題解決、教育・研究機関の管理体制や構造の改革と再編、及び大学の資源を再配分することに貢献し得る人材育成をするための、魅力的なグローバル研究拠点の創設を目標としている。
研究面において北海道大学では、総長直轄の GI-CoRE という研究教員組織を設置し、北大の研究チームと共同研究を行う世界トップレベルの研究チームを誘致し、革新的な国際連携
研究・教育を行っている。また、GSQ の所属教員は継続的に数多くの共同論文を発表しており、それは極めて素晴らしい功績となっている。GSQ は放射線治療の最先端分野において、中心的な役割を担い、技術革新の創造の可能性を広げてくれている。さらに、AI、radiomics (放射線医学 Radiology と-omics 多量の情報を統計的に扱う科学とが合成された言葉)、ゲノミクス（genomics）においても新たな研究を始めており、この研究結果は、いずれ放射線治療を通じて社会的問題の解決につながることが期待される。
教育面においては、GSQ の研究結果に基づき、しっかりと整った枠組みが出来上がっている。2017 年 4 月には医理工学院を開設し、海外から参加者を誘致の上、医学物理学に関する
夏季セミナー（医学物理サマースクール）を開催しており、2018 年からはセミナーの内容が放射線生物学にまで及んでいる。この大学院では理学研究院、保健科学研究院、工学研究院、医学研究院、歯学研究院等の教員たちが、量子科学と工学、分子科学と工学の医学の分野に有用な知識を持ったスペシャリストたちの専門教育の場に参加している。
GSQ の設置は、国際的なコラボレーションの模範的なプログラムであると言える。北大とスタン
フォード大学の非常に優れた臨床教授や科学者たちが中心となり、アメリカ合衆国の UCSF（カリフォルニア州立大学サンフランシスコ校）や、京都大学、大阪大学からの研究者たちも加わっている。それぞれの機関における強みを際立たせるような研究と教育成果に重きを置きつつ、指揮しており、それにより綿密で極めて効果的な共同研究が行われている。

要約をすると、GSQ は国際連携研究・教育を行う体系と枠組みの創設を成し遂げ、プロジェ
クト開始後、称賛に価する著しい進歩を遂げている。我々は北大が今後も研究、教育、そして現行の運営体制を維持し、GSQ プロジェクトをさらに推し進めて行くことを推奨する。

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Final Evaluation Report(original version in English)
外部評価報告書（英語・オリジナル版）

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Contents
Foreword •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 15
External Evaluation Committee ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 17
Schedule of the External Evaluation Committee •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 21
Results of the Evaluation Committee •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 23
Research Progress Report (2014-2019) •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 43
References •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 131

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Foreword
Hokkaido University established the Global Institution for Collaborative Research and
Education (GI-CoRE) as a faculty organization under the direct control of the President thatbrings together world-class researchers from around the world and within the University. It
aims to promote international collaborative research and education that leverages the
University’s strengths and distinctive features as well as to provide support for international
collaborative research and education promoted by faculties and centers, respectively.
Under the GI-CoRE system, a research and education hub known as a Global Station (GS) is
implemented for each research field. GSs have a finite implementation period of five (5) years
in principle to conduct intensive research and education activities. Thus far, seven (7) GSs in
total (see * below) have been implemented to further develop research activities and contributethe resulting cutting-edge research outcomes to graduate school education.
In the final year of the GI-CoRE project period, a Final Evaluation is conducted by the External
Evaluation Committee composed of global experts outside Hokkaido University for each GS
to not only review GS activities from past years but also build a stronger and more sustainable
research and education system in the future.
This Final Evaluation Report contains the Research Progress Report of GS for Quantum
Medical Science and Engineering (GSQ) conducted in August 2018 and the evaluation results.
This report is a compilation of the research and education activities of GSQ.
After the implementation period, GS projects are transitioned into affiliated faculties andcenters, then certified as “GI-CoRE Cooperating Hubs” to continue research and education
activities in cooperation with GI-CoRE after April 2020.
Hokkaido University remains committed to continuing its efforts to contribute to resolving
global issues by conducting advanced research and education activities based on evaluation
results.

Professor Masanori Kasahara, M.D., Ph. D.
Interim Director
Global Institution for Collaborative Research and Education (GI-CoRE)
Hokkaido University(Interim President, Hokkaido University)

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*The Global Stations (GSs) implemented thus far.
Implementation

Name of the GS
Quantum

MedicalScienceand

2014–2019

Engineering
Zoonosis Control

Main Internal Affiliation

Period (FY）

Faculty of Medicine, University Hospital,and others

2014–2019

Research Center for Zoonosis Control andFaculty of Veterinary Medicine

Food, Land and Water Resources

2015–2019

Research Faculty of Agriculture and others

Soft Matter

2016–2020

Faculty of Advanced Life Science and others

Big Data and Cybersecurity

2016–2020

FacultyofInformation

ScienceandTechnology and others
Arctic Research

2016–2020

Arctic Research Center and others

Biosurfaces and Drug Discovery

2019–2023

Faculty of Pharmaceutical Sciences andothers16

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education (GI-CoRE)
External Evaluation Committee*Professor Kazuhiko Ogawa,
Osaka University (Japan)
Professor Constantinos Koumenis,
University of Pennsylvania (United States)

Professor Xian-shu Gao,
Peking University First Hospital (China)*Chair17

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$WWDFKPHQWLetter of Acceptance
19/03/2018

To Director Toyoharu Nawa of Global Institution for Collaborative Research and
Education (GI-CoRE) at National Corporation Hokkaido University,

I hereby accept my appointment to serve as a member of the External
Evaluation Committee for Global Station for Quantum Medical Science andEngineering at Global Institution for Collaborative Research and Education (GICoRE), Hokkaido University.

Signature

Director Xian-Shu Gao
Dept. of Radiation Oncology, Peking University First Hospital20

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education(GI-CoRE)
Schedule of the External Evaluation Committee

1. Date of Implementation
Wednesday, August 8, 2019
2. On-site Investigation Schedule
Time

Contents

3:00pmOpening Remarks and Briefing by GI-CoRE Director Toyoharu Nawa

3:10pmInterview Session #1 (Overview)
Professor Hiroki Shirato
Professor Quynh-Thu Le

3:35pmInterview Session #2（Clinical Science Section）
Professor Shin-ichi Shimizu, Lecturer. Khin Khin Tha
Professor Daniel Chang

3:55pmInterview Session #3（Medical Physics Section）
Professor Kikuo Umegaki, Associate Professor Taeko Matsuura,
Associate Professor Naoki Miyamoto
Professor Lei Xing

4:15pmInterview Session #4（Radiation Biology Section）
Senior Assistant Professor Jin-Min Nam
Professor Amato Giaccia

4:35pmQ&A Session

5:00pmDiscussion among committee members

5:30pmReview from the committee to the faculty members（- 5:50pm End of schedule）

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Results of the Evaluation Committee

Evaluation Committee

Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education (GI-CoRE)
Hokkaido University
October 201823

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Summary Report
Professor Kazuhiko Ogawa, Osaka University (Japan)
Professor Constantinos Koumenis, University of Pennsylvania (United States)
Professor Xian-shu Gao, Peking University First Hospital (China)
Comprehensive Evaluation

S / A / B / C / D (circle one)

The objectives of this program are to establish an attractive global research hub that is designed tonurture human resources who can contribute to address various issues in the world, and to reform andreorganize the governance and framework of the educational research organization, and also to assist in
the reallocation of the resources of the university.
Regarding researches, HU has established the GI-CoRE as an educational research institution under
the direct authority of the university president, where innovative international research is conducted
through the collaboration effort between world leading educational research teams invited from overseas
research institutions working together with research groups of HU. Also, GI-CoRE members havecontinuously published an impressive number of manuscripts together, in the areas of proton therapy,
physics of target verification and organ motion compensation, that are extremely excellent point for
GI-CoRE. GI-CoRE has played the active roles in the reforms and enables the creations of innovativetechnologies regarding radiotherapy. Moreover, GI-CoRE has stared new studies regarding AI, radiomics
and genomics. Some of research results from GI-CoRE results are expected to effectively solve social
issues regarding radiotherapy treatments.
Regarding education, the educational framework has been fully prepared based on the research
results from GI-CoRE project. Furthermore, HU has started a “Graduate School of Biomedical Scienceand Engineering” from April, 2017. GI-CoRE has also hold summer seminars regarding medical physics
for participants from several countries, and the contents of these seminars have been extended to radiation
biology from 2018. In this graduate school, teaching staff of the Faculty of Science, the Faculty of Health
Sciences, the Faculty of Engineering, the Graduate School of Medicine, and the Graduate School of
Dental Medicine participate in the education of specialists who will be able to contribute their knowledgeof quantum science and engineering as well as molecular science and engineering to medicine.
Regarding establishment of framework, GI-CoRE has been established as an exemplary programfor international collaboration. It is headed by exceptional clinician-scientists from both HU and SU andcollaborations have been initiated with additional institutions, such as UCSF in the US, and Kyoto andOsaka University in Japan. The leadership has wisely chosen to focus research and educational efforts
which represent strengths at each institution, thereby creating rigorous and highly effective researchcollaborations.
In summary, GI-CoRE project has successfully established the system and framework necessary to
conduct international cooperative research and education, and the impressive and significant progress has

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been made since the start of the project. We recommend that HU should proceed with the GI-CoRE
project with continuous researches, educations and the current managements.

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education (GI-CoRE)
Final Evaluation
External Evaluation Committee Member Name: Kazuhiko Ogawa

Choose one of the five Evaluation Ratings options below as explained by the Evaluation Explanation for each
Evaluation Item on the form.
Evaluation

Evaluation Explanation

Ratings
S

Achieved outcomes surpassed the original plan (Outstanding)A

Good progress has been maintained and expected outcomes have been achieved(Excellent)

B

Most expected outcomes have been achieved with some slight delays (Good)C

Although certain outcomes were achieved, overall results were insufficient (Satisfactory)D

No expected outcomes were achieved (Unsatisfactory)

I. Research1.

Has construction of an international research and education center capable of attracting outstanding

researchers from around the world (including from HU) been achieved?
Evaluation Results and Reasons(Your Evaluation Results)
S/ A / B / C / D (circle one)
(Reasons)
An international research and education center that gathers outstanding researchers from the inside andoutside of Hokkaido University (HU) has been well constructed till now. World-leading researchers of Stanford
University (SU) have been invited to HU to build a Stanford unit in the GSQ as a counterpart of the HU unit andstarted collaborative studies in the field of radiation biology, radiation oncology and medical physics. Also,international symposia and summer schools on a regular basis have been held to promote further collaboration andthe sharing of important scientific insights. Regarding symposia, several areas of world-wide active researchers
have been invited, and they have contributed to give “knowledge of showers” to the attending researchers andstudents. They also have contributed to take the chances of further collaboration studies of different areas to theattending researchers. Regarding inside persons, a total of 14 persons by HU including 1 person of head of the unit,
7 persons of clinical science section, 5 persons of medical physics section and 5 person of radiation biology section
has been organized. Regarding outside persons, a total of 18 persons by SU including 1 person of head of the unit, 427

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persons of clinical science section, 8 persons of medical physics section and 5 persons of radiation biology section
has been organized. The number of these researchers have increased as compared to that of 2 years before. Also,
faculty members of other facilities, such as University of California, Groningen University, National Institute ofRadiological Science, Kyoto University, Osaka University and Tohoku University have contributed as lectures in
the Summer school for Medical Physics and Radiation Biology, and also the in the GI-CoRE symposium in
Sapporo. Regarding education, HU has opened a “Graduate School of Biomedical Science and Engineering” inApril 2017 based on the research outcomes at the GSQ. This new graduate school will contribute to theparticipation in the education of specialists who will be able to contribute their knowledge of quantum
science and engineering as well as molecular science and engineering to medicine. The new graduate
school will help the students to attain a basic knowledge of medical fields, and enable the graduate
specialists to be equipped with the highest ethical and humanitarian qualities.

Specific points(Outstanding points)
GI-CoRE has already established the collaboration system between HU and SU, a world-leadinginternational academic facility. Furthermore, new graduate school has opened in April 2017, that will help
the students to attain a basic knowledge of medical fields, and enable the graduate specialists to beequipped with the highest ethical and humanitarian qualities.

(Suggestions for improvement)
None.
2.

Is world-leading cutting-edge international cooperative research underway?

Evaluation Results and Reasons(Your Evaluation Results)
S / A / B / C / D (circle one)
(Reasons)
GI-CoRE has conducted the cutting-edge international cooperative researches from 2014. HU has heled to use
their resources to start international collaborative clinical trials in radiation oncology. International clinical trials
have been conducted to test the role of stereotactic ablative radiotherapy in improving the survival rates of thepatients with lung or live cancer, while measuring cDNA in the blood test that can serve as a potential surrogate
marker for treatment success of failure. Regarding medical physics, researches have been conducted to visualize 2D
gold concentration distributions in objects by observing the amount of fluorescence X-rays when proton beams
collided with gold at HU. Also, the medical physics team has conducted the studies developing technologies todetermine proton ranges in real-time by observing ultrasonic waveforms emitted from the irradiated target during
treatment. Also, data-driven models using normal tissue complication probability (NTCP) have been studied. In
parallel with the rapid progress of machine learning and artificial intelligence (AI), the radiomics group will be28

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separated from the Clinical Science Section and be set up as a new unit for AI. Regarding radiation biology, themolecular mechanisms of radiation effects to improve the efficacy of radiation treatment on cancer cells have beenstudied by SU. Also, molecular mechanisms of cancer cell invasion and metastasis have been investigated by HU.
In addition, molecular imaging regarding hypoxia has been studied along with the clinical studies.
Specific points(Outstanding points)
Many studies conducted by GI-CoRE have been innovative and cutting-edge. Also, many research results
have been already published, and many presentations have been conducted till now. There are already 77
publications, 51 verbal presentations and 4 awards received from the beginning of GI-CoRE at 2016. At 2018, Thereare 215 publications, 204 verbal presentations and 11 awards received. There are increasing numbers of research
results. That is an extremely excellent point for GI-CoRE. These study groups have commenced to study new
themes including AI and genomics.
(Suggestions for improvement)
None
3.

Are research outcomes from GI-CoRE being actively utilized to solve social issues?

Evaluation Results and Reasons(Your Evaluation Results)
S / A / B / C / D (circle one)
(Reasons)
Radiotherapy is one of the most cost-effective curative treatments for cancer, and has the potential to maintainexcellent function and form in patients during and after the treatment. Therefore, there are increasing demands for
precise radiotherapy technology, cutting-edge knowledge of radiation biology, imaging technology, andwell-organized clinical trials to improve the outcome of cancer treatment using radiotherapy. GI-CoRE has alreadyplayed the active roles in the reforms and enables the creations of innovative technologies regarding radiotherapy.
Some of research results from GI-CoRE results are expected to solve social issues regarding radiotherapy
treatments.
Specific points(Outstanding points)
The studies conducted by the GI-CoRE have important aspects regarding cancer, and these studies willcontribute the success of radiotherapy treatment effectively, thereby satisfying the demands of social issues.
(Suggestions for improvement)
None.

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II. Education
Is the educational system and curriculum designed to help develop researchers who possess specialized knowledge
and are capable of working internationally?
Evaluation Results and Reasons(Your Evaluation Results)
S/ A / B / C / D (circle one)
(Reasons)
The educational framework has been fully prepared based on the research results from GI-CoRE project.
Furthermore, HU has opened a “Graduate School of Biomedical Science and Engineering” in April, 2017. In thisgraduate school, teaching staff of the Faculty of Science, the Faculty of Health Sciences, the Faculty of Engineering,
the Graduate School of Medicine, and the Graduate School of Dental Medicine will participate in the education of
specialists who will be able to contribute their knowledge of quantum science and engineering as well as molecularscience and engineering to medicine. GI-CoRE also have held a summer seminar for participants from several
countries, such as USA, UK, Nigeria, Columbia and Japan for each year. The contents of the seminar included
medical physics till 2017, and have extended to radiation biology in addition to medical physics from 2018.
Moreover, practical trainings regarding the part of the lectures has been added if possible. These seminars havereceived positive feedback in general regarding the contents and the quality of lectures.
Specific points(Outstanding points)
GI-CoRE aims to conduct studies to develop medical equipment to meet the needs of business and industry
while promoting research related to medical physics and radiation biology for academia in our mission to meet thevariety of needs of society.
(Suggestions for improvement)
None.

III. Establishment of Framework
Are the necessary systems and frameworks being established in order to conduct international cooperative researchand education?
Evaluation Results and Reasons(Your Evaluation Results)
S / A / B / C / D (circle one)30

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(Reasons)
GI-CoRE has already established an attractive global research hub that is designed to nurture human resources
who can contribute to address various issues in the world. For example, HU has prepared a highly equipped wetlaboratory of 200m2 for radiation biology. Also, HU has prepared a dry office of 150 m2 for the medical physics
section and an administration office in the proton beam therapy center. These establishments of frameworks havebeen sufficiently supported by the budgets for GSQ and GI-CoRE.
Specific points(Outstanding points)
Hokkaido University has set up a GI-CoRE-specialized administrative section in the Office of International
Affairs, distributed staff members with study/work abroad experiences to the section, and established bilingual(English) administrative support system. Also, bilingual staffs have been stationed in each global station office tosupport daily research activities conducted there.
(Suggestions for improvement)
None.

IV. Overall Evaluation
The objectives of this program are to establish an attractive global research hub that is designed to nurture
human resources who can contribute to address various issues in the world, and to reform and reorganize thegovernance and framework of the educational research organization, and also to assist in the reallocation of theresources of the university. At present, HU has established the GI-CoRE as an educational research
institution under the direct authority of the university president, where innovative international researchis conducted through the collaboration effort between world leading educational research teams invitedfrom overseas research institutions working together with research groups of HU. Regarding Global
Stations for Quantum Medical Science and Engineering, the management of this section is going well atpresent. I think that GI-CoRE project has established the system and framework necessary to conduct international

cooperative research and education. Moreover, these conditions have more progresses as compared to those 2
years before. Recently, new issues regarding AI, radiomics and genomics have emerged to effectively solve
the social problems, but yet to be done. Therefore, I recommend that HU should proceed with the GI-CoRE
project with continuous researches, educations and the current managements.

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32

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education (GI-CoRE)
Final Evaluation
External Evaluation Committee Member Name: Constantinos Koumenis

Choose one of the five Evaluation Ratings options below as explained by the Evaluation Explanation for each
Evaluation Item on the form.
Evaluation

Evaluation Explanation

Ratings
S

Achieved outcomes surpassed the original plan (Outstanding)A

Good progress has been maintained and expected outcomes have been achieved(Excellent)

B

Most expected outcomes have been achieved with some slight delays (Good)C

Although certain outcomes were achieved, overall results were insufficient (Satisfactory)D

No expected outcomes were achieved (Unsatisfactory)

I. Research1.

Has construction of an international research and education center capable of attracting outstanding

researchers from around the world (including from HU) been achieved?
Evaluation Results and Reasons(Your Evaluation Results)(S) / A / B / C / D (circle one)
(Reasons)
Since the last review period (2016), the GI-CORE has been firmly established as a premier international
research and education center. The level of international cooperation in performing transformational translational
science is clearly evident by the prominent scientists collaborating in clinical, physics and biology projects.

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Specific points(Outstanding points)
The center has initiated two state-of-the-art clinical trials in Stereotactic Ablative Radiotherapy (SABR) in•

which (a) SABR is directly compared to the standard of care in hepatocellular carcinoma, and (b) circulatingtumor DNA (ctDNA) is used as a surrogate marker of response to SABR in lung carcinoma. This represents asignificant development in the mission of the center, as it leverages expertise at both institutions and has
trained clinical research coordinators in Japan to perform the trial in coordination with the Stanford PIs.
Implementation of outstanding expertise in medical physics and imaging and SU and machine•learning/bioinformatics at HU to develop a highly competitive radiomics program
Incorporation of world-class science in circulating tumor DNA (ct DNA) in developing predictive models of•

response to radiotherapy
Establishment of a new, state-of-the-art Radiation Biology Laboratory at the GI-CORE in Hokkaido, and•recruitment of talented faculty into the program
Since the recent establishment of the Graduate School of Graduate School of Biomedical Science and•Engineering students have begun to matriculate in the GI-CORE program
Highly successful Summer Program in Radiation Oncology, attracting young talented students form all over•

the world.

(Suggestions for improvement)
None noted2.

Is world-leading cutting-edge international cooperative research underway?

Evaluation Results and Reasons(Your Evaluation Results)(S) / A / B / C / D (circle one)
(Reasons)
Indeed, as mentioned above, highly innovative, translational science is being performed in all three areas of
Radiation Oncology (Clinical, Physics and Biology).
Specific points(Outstanding points)
There have been notable improvements in the performance of innovative and in some case, transformative
science. For example:•

The initiation of two international clinical trials mentioned above, with potential for recruiting additional
centers form Japan (e.g., for particle therapy treatment) and other countries.

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•The radiomics program is well underway with impressive publications in the areas of multiparametric
imaging (MPI) and machine learning. For example, a manuscript published in Radiology (IF 7.5) describedsuperior performance of MPI compared to existing prognostic indicators in predicting overall survival of
glioblastoma patients. Additional projects in the area of using MPI to distinguish different subtypes of GBM
as well as breast cancer have also been published in impactful journals. MPI and machine learning are areasof intense focus and development world-wide and have the potential to revolutionize patient treatment.

•

Moreover, the Physics projects employing organ motion movement, photoacoustic and X-Ray imaging
approaches for Protons and X-Rays as well as use of nanoparticles to enhance radiotherapy effectivenessmatured and either published or presented at prestigious international meetings (e.g., AAPM). The
collaboration between Physicists at HU and SU is a major strength of the GI-CORE, and is supported bymultiple visits and cross-appointments of Physicists from SU to HU, and, since the last review of the
program, from HU to SU. In my estimation, the combined efforts between the Radiation Physicists form
HU and SU represent one of the top 2-3 teams internationally which are working on improving clinical careof radiation patients.

•

Despite essentially starting the Biology program “from scratch”, new faculty (Dr. Onodera) has been
recruited which is already publishing exciting work in the area of mitochondrial biology and oxidative stress(Nat. Communications).

Moreover, there has been progress in the areas of nanotechnology with

RGD-peptides as radio-enhancers and in the investigation of the effects of radiation in the invasive activityof breast tumor cells.

(Suggestions for improvement)•

An area for potential improvement is the incorporation of immunocompetent mouse models to initiate
studies on the impact of radiotherapy in the immune response to tumors (especially as it applies toProton radiotherapy).

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3.

Are research outcomes from GI-CoRE being actively utilized to solve social issues?

Evaluation Results and Reasons(Your Evaluation Results)(S) / A / B / C / D (circle one)
(Reasons)
Yes, the new clinical trials which have been initiated by the GI-CORE have the distinct potential to improve patientcare at an international level. Moreover, the established interactions between the GI-CORE and the Graduate Schoolof Biomedical Science and Engineering offer excellent opportunities for high-level graduate education to several
students interested in radiation sciences and reciprocally, offer opportunities to GI-CORE faculty to disseminate
knowledge and expertise to the broader academic community.
Specific points(Outstanding points)•

Collaborative, state-of-the-art research has been reported in both Japanese journals (5), and in international(overseas) Journals (29).

(Suggestions for improvement)
None noted

II. Education
Is the educational system and curriculum designed to help develop researchers who possess specialized knowledge
and are capable of working internationally?
Evaluation Results and Reasons(Your Evaluation Results)(S) / A / B / C / D (circle one)
(Reasons)
Exceptional progress in the field of education.

Two Summer Schools (Physics and Biology) have been

established, several major symposia have been held at the GSQ and the newly established Graduate School of
Biomedical Science and Engineering will have a major positive impact on the operations and scope of the
GI-CORE.

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Specific points(Outstanding points)•

The newly established Graduate School of Biomedical Science and Engineering represents a major
development, positively impacting the efforts of the GSQ. This will (a) attract talented graduate students
into research efforts of the GI-CORE and (b) allow the GI-CORE scientists (both form HU and the visiting
professors from SU) to gain valuable teaching experience and also disseminate knowledge accumulated
during the GI-CORE functions.

•

An impressive number of educational activities have taken place under the auspices of the GI-CORE,
including summer symposia with internationally-renowned scientists, a Summer School for Medical
Physics (currently in its 5th year), and a newly established Summer School in Radiation Biology.

(Suggestions for improvement)
None noted

III. Establishment of Framework
Are the necessary systems and frameworks being established in order to conduct international cooperative researchand education?
Evaluation Results and Reasons(Your Evaluation Results)(S) / A / B / C / D (circle one)
(Reasons)
Since its inception in April 2014, the GI-CORE has firmly established a robust and sustainable framework for
performing high-caliber research, training new scientists and disseminating the resulting scientific findings to thebroader international scientific community.

Specific points(Outstanding points)•

Effective steering committee of the GI-CORE consisting of top, experienced officials appears to provide
strong stewardship for activities and meets regularly and provides guidance and oversight.

•

Outstanding leadership from both the HU and SU teams, particularly Drs. Shirato and Le, who are leading
the GI-CORE efforts.

•

Efficient mode of operations with cross-appointment of faculty and opportunities for training of both faculty37

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and staff.

(Suggestions for improvement)
None noted

IV. Overall Evaluation
Since its establishment in 2014, the GI-CORE has developed into one of the premier centers for Radiation
Oncology Research. The initiation of two pivotal clinical trials with patients from both the US and Japan and tightcooperation between the clinical research groups at HU and SU, represents a model for similar future international
collaborations. New research directions into the application of radiomics, machine learning and photoacoustic
imaging are timely and cutting-edge. The Biology unit has now been adequately staffed and already making big
strides with high-impact publications and excellent potential for future contributions. Finally, the international
educational activities offered by the GI-CORE in Radiation Sciences are unparalleled. Going forward,
implementation of the research findings into additional innovative clinical trials, translating Physics findings into
new equipment or procedures and expanding radiomics efforts to include biochemical markers with ctDNA fromthe ongoing research efforts, has the potential to propel the GI-CORE to the forefront of Radiation Oncology
academic entities.

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education (GI-CoRE)
Final Evaluation
External Evaluation Committee Member Name: Xianshu Gao（高献书）Choose one of the five Evaluation Ratings options below as explained by the Evaluation Explanation for each
Evaluation Item on the form.
Evaluation

Evaluation Explanation

Ratings
S

Achieved outcomes surpassed the original plan (Outstanding)A

Good progress has been maintained and expected outcomes have been achieved(Excellent)

B

Most expected outcomes have been achieved with some slight delays (Good)C

Although certain outcomes were achieved, overall results were insufficient(Satisfactory)D

No expected outcomes were achieved (Unsatisfactory)

I. Research1.

Has construction of an international research and education center capable of attracting outstanding

researchers from around the world (including from HU) been achieved?
Evaluation Results and Reasons(Your Evaluation Results)
S/ A / B / C / D (circle one)
(Reasons)
Specific points(Outstanding points)
1. Extremely impressive and significant progress has been made since the start of the project, especiallyin research and development through collaboration among medical, science, and engineering faculty
participants.
2. The teachers invited from overseas have met the requirements for medical physics section andradiation biology section. They have spearheaded a number of important initiatives in research andeducation. The participation and collaboration have been very effective and greatly advanced the field of
medical technology and healthcare.
3. The role cooperative systems with the affiliated universities are very appropriate.

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4. The inter-departmental role cooperative systems within Hokkaido University are very appropriate
and exemplify the power of multidisciplinary research.
(Suggestions for improvement)
None.
2.

Is world-leading cutting-edge international cooperative research underway?

Evaluation Results and Reasons(Your Evaluation Results)
S/ A / B / C / D (circle one)
(Reasons)
Specific points(Outstanding points)
1. Research is progressing smoothly and has exceeded the original plan in multiple aspects. Research
program is exceedingly productive and fruitful.
2. Significant clinical trials are carrying out smoothly. Although research results of these clinical trials
will be available after several years, there is sufficient prospect of publishing high quality international
collaborative papers.
3. The radiation biology section has obtained research results which have significant scientific impact.
(Suggestions for improvement)
None.
3.

Are research outcomes from GI-CoRE being actively utilized to solve social issues?

Evaluation Results and Reasons(Your Evaluation Results)
S/ A / B / C / D (circle one)
(Reasons)
Specific points(Outstanding points)
1. Compared with the last appraisal, there are much more research results that lead to the resolution ofsocial issues from GI-CoRE.
2. The methods of communication from GI-CoRE to society are very appropriate.
3. There are feasible plans to collaborate with research organizations or corporations as well as theaffiliated universities with an aim of solving social issues.

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(Suggestions for improvement)
None.
II. Education
Is the educational system and curriculum designed to help develop researchers who possess specialized knowledge
and are capable of working internationally?
Evaluation Results and Reasons(Your Evaluation Results)
S / A / B / C / D (circle one)
(Reasons)
Specific points(Outstanding points)
1. The curriculum is highly useful and important to foster inter-disciplinary students.
2. The goal of the Graduate Schools is clear, the organization of the personnel structure is reasonable,
and the research area is also cutting-edge.
3. The Graduate Schools expand its influence and popularity through different ways, such as Summer
School.
(Suggestions for improvement)
None.

III.

Establishment of Framework

Are the necessary systems and frameworks being established in order to conduct international cooperative researchand education?
Evaluation Results and Reasons(Your Evaluation Results)
S / A / B / C / D (circle one)
(Reasons)
Specific points(Outstanding points)
A sufficient system and framework have been established to invite top researchers and conduct
international cooperative research and education.

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(Suggestions for improvement)
The educational framework is well designed, especially considering the broad spectrum of the attendees
and students. It may be useful to individualize the educational program by offering courses at two morelevels.

IV. Overall Evaluation
This program has constructed an international research and education center to carry out cutting-edge
international collaborative research, which can be used to solve social issues. Based on these research results,
this program has built Graduate Schools to develop personnel who have specialist knowledge and can act
globally. The breadth and depth of this program can be further improved by extending this program basedon this framework. For instance, researchers invited from overseas for clinical science section have notenough time to prepare and carry out more significant international multi-center clinical trials.

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Global Station for Quantum Medical Science and Engineering
Global Institution for Collaborative Research and Education(GI-CoRE)
Hokkaido University
Research Progress Report(Project Period: Academic Year 2014-2019)43

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Contents
I. Overview ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 47

II. Budget•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 51

III. Detailed Results (FY 2014-2018) ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••52
1. Research•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 52
2. Education (Graduate Schools to Foster Global Human Resources) ••••••••••••••••••••••••••••••••••••••••••••••••••• 101
3. Establishment of Framework •••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 105

IV. Supplemental Revision (FY 2018-2019)•••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 108

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46

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I. Overview■ Name of Global Station: Global Station for Quantum Medical Science and Engineering (GSQ)■ Project Period: 2014-2019 academic years (5 years)■ Aims and Goals
The objectives of this program to establish an attractive global research hub that is designed tonurture human resources who can contribute to addressing various issues in the world, to reforming
and reorganizing the governance and framework of the educational research organization, as well toassisting in the reallocation of the resources of the university. To achieve these objectives, Hokkaido
University (HU) has established the Global Institution for Collaborative Research and Education (GICoRE) as an educational research institution under the direct authority of the university president,
where innovative international research is conducted through the collaborative efforts between world
leading educational research teams invited from overseas research institutions and research groups of
HU. The GI-CoRE currently consists of six global stations: Global Stations for Quantum Medical Scienceand Engineering, for Zoonosis Control, for Food, Land and Water Resources, for Soft Matter, for Big
Data and Cybersecurity, as well as that for Arctic Research. (Fig. 1).

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48

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Fig 1. Configuration of GI-CoRE (as of March 2018)

■ Necessity and Urgency
Cancer is one of the main causes of death in developed countries and the numbers of cancer patientsare increasing in developing nations. An optimal cancer treatment would be one that can completely
cure all patients while maintaining reasonable cost-effectiveness. In reality however, the success ratesof treatments are less certain and the costs of anti-cancer pharmaceuticals are growing. Consequently,
costs associated with cancer treatment are becoming a significant burden for national health services
everywhere. Alternative solutions for treatment are thus urgently needed to help address this severe
global issue.
Radiation therapy is one of the most cost-effective curative treatments for cancer and has great
potential for allowing patients to maintain excellent function and form during and after treatment.
There is increasing demand for precise radiotherapy technology, cutting-edge knowledge of radiation
biology, imaging technology, and well-organized clinical trials to improve the outcome of cancer
treatment using radiation. However, even with the most advanced radiotherapy, it is still not possible
to cure all cancer patients with reasonable cost-effectiveness. Innovation is urgently needed to improve
the outcome through studies in physics, biology, and clinical sciences with the collaboration among
different countries as well as that between academia and industry. HU is willing to realize a “Hokkaido
University that proposes solutions for problems experienced globally” in this field of cancer treatmentusing the framework of the GI-CoRE.
■ Originality, Novelty, etc.
The Global Station for Quantum Medical Science and Engineering (GSQ) has been established aspart of the Global Institution for Collaborative Research and Education (GI-CoRE) in 2014 to solve
problems in cancer treatment. The GSQ is one of the main efforts of HU to establish innovative research
centers for international collaborative studies and developing human resources who will be able toassume responsibility for upcoming generations.
HU has a long history conducting unique researchon organ motion, developed new treatment systems,
and also conducted related clinical studies on precise
external beam radiotherapy. The Real-time tumortracking radiotherapy (RTRT) realized in 1999 andreal-time-image gated proton beam therapy (RGPT) in2013 are often cited in world-class journals andconferences.
The Department of Radiation Oncology, Stanford
University (SU) School of Medicine is a well-established,
world-leading research group. It developed the first
Fig.2 Proton beam therapy system withlinear accelerator in the Western Hemisphere andreal-time tumor-tracking function.
administered photon treatment using a linear
accelerator in 1956. In collaboration with Stanford Neurosurgery, it also developed Cyberknife in the
1990’s, which is still presently used throughout the world for stereotactic ablative radiotherapy (SABR)
for intracranial and extracranial tumors.
In 2013, the Department of Radiation Medicine and head-quarters of HU explained their idea ofdeveloping the GSQ to the Department of Radiation Oncology and related authorities in the Stanford
School of Medicine. After months of discussion, SU understood the dedication of HU, potential of the GICoRE, scientific validity in collaborating with HU, and agreed to join the GSQ. World-leading researchersof SU have been invited to HU to build a Stanford University unit in the GSQ as a partner of the
Hokkaido University unit and started collaborative studies in the field of radiation biology, radiation
oncology and medical physics (Fig. 3).

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As physical places for research and equipment,
HU has prepared a highly equipped wet laboratory of
200 m2 for radiation biology in the Graduate School of
Medicine building. Hokkaido University Hospital has
also prepared a dry office of 150 m2 for the Medical
Physics Section and an administration office in the
Proton Beam Therapy Center. Hokkaido University
Hospital also helped with use of their resources tostart international collaborative clinical trials inradiation oncology.
Four professors including the chair of thedepartment, associate/assistant professors, and otherresearchers of the Department of Radiation Oncology,
Fig.3 Global Station for Quantum Medical Science andStanford University have visited their units in HU
Engineering.
from periods of one-week to one-year. To facilitate theresearch, HU also introduces various new
arrangements for personnel affairs including an annual salary appointment scheme and crossappointment arrangements; it also assigns research funds selectively to promote and support the GICoRE. Furthermore, the facilitation also provides special considerations such as exemptions frommanagement duties and from policies/regulations of each department to enable the researchers to
conduct educational research activities without being constrained.
At the GSQ, innovative international research through the collaboration between HU and SU willcontribute to the scientific community by producing high impact co-authored papers that are widely cited.
Conducting international symposia and summer schools on a regular basis will also help to promotefurther collaboration and the sharing of important scientific insights.
HU created a new institute, the “Graduate School of Biomedical Science and Engineering” in April,2017 by reallocation of enrollment places and faculty of existing graduate schools based on their worldleading research achievements. Integration of the research results and achievements of the GSQ is
expected to grow into the development of the graduate schools for upcoming generations. The
globalization of the student body will be accelerated through credit transfer arrangements with affiliateduniversities and increase the number of students who study outside Japan.
These activities make it possible to facilitate research conducted in the GSQ and enable the trainingof future international leaders through education at the new graduate school.
It is expected that the results of this project will make a very important contribution to the strategy of
HU, “establishing innovative research centers for international collaborative studies and developing
human resources who will be able to assume responsibility for coming generations”, that will be essential
to realizing the goal of solving global problems.

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II. Budget
Unit: 1,000 JPY
Category

FY 2014

FY 2017

10,58336,462

21,22045,251

113,516

25,93815,30890,482

66,451

198,179

32,05500

032,055

10,075

18,662

23,062

26,82540,000118,624

Administrative
cost*

20,60926,122

27,232

28,057

24,725

126,745

Operating andresearch cost

67,80076,00054,392

53,97333,275285,440

98,484

189,360

156,456

220,557

209,702874,559

Operating cost
Facility cost
Personnel cost

GI-CoRE
establishmentof framework

Total

Total

FY 2016

Personnel cost
Budget for
GSQ

FY 2018

FY 2015(for researchers fromoverseas)(projected)*Including travel expenses for invited researchers from overseas.

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III. Detailed Results
1. Research(1) Goals
Under the framework of the GSQ, investigators have engaged in research and development throughcollaboration among medical, science, and engineering faculty participants. The objectives of these three
sections are: (a) The Clinical Science Section works to realize a cancer treatment that prevents recurrence
and metastasis, (b) The Medical Physics Section works to establish the basics and technology involved in
the research of 3D Real-time Imaging and dose determinations for radiation therapy, and (c) The Radiation
Biology Section conducts creative medical research through study of the effects of radiation sensitizers andprotective agents and that of molecular biology to control recurrence and metastasis.
(2) Current Progress/Future Developments① Construction of base
As of March 2018
Affiliated institutions,departments, etc.

Researcher name

Description of research

Hokkaido University(Clinical Science Section)・Study and enable medical

Faculty of Medicine

Professor, Shinichi Shimizu

treatments to avoid recurrence andFaculty of Engineering

Associate Professor,

metastasis

Faculty of Health Sciences

Kohsuke Kudo

・Development of minimally invasive

Hokkaido University

Senior Assistant Professor,

innovative, advanced radiotherapy

Hospital

Noriko Manabe

・Development of real-time tumor

Senior Assistant Professor,

tracking technology【Head of the unit】

Khin Khin Tha

・International clinical studies toProfessor, Hiroki Shirato

Senior Assistant Professor,

measure cDNA (cancer cell genes in

Daisuke Abo

the blood) to improve survival rates ofAssistant Professor,

cancers

Norio Katoh

・Development of minimally invasive

Assistant Professor,

markers for in vivo applications

Tetsuya Inoue

・Development of quantitative*Collaborative Researcher

imaging technology with radiomics

Yoriko Ida

・ Development of a system that
automatically detects metastases(Medical Physics Section)

・ Research and development of 3D

Professor, Kikuo Umegaki

real-time imaging

Professor,

・Development of dose determination

Masayori Ishikawa

technology for radiation therapy

Associate Professor,

・ Development

Taeko Matsuura

imaging technology

Assistant Professor,

・ Development of real-time marker-ofprotonbeam

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Seishin Takaoless tracking technology

Assistant Professor,

・Research related to development ofKenneth Sutherlandcone beam CT technology(Radiation Biology Section)

・ Study of the effects of radiation

Senior Assistant Professor

sensitizers and protector

to be appointed

・Research of reactive oxygen species

Assistant Professor,

relatedKoichi Yasuda

invasive breast cancer

molecular

mechanismin*Collaborative Researcher
Yasuhito Onodera

Stanford University(Clinical Science Section)

・Randomized Study of Transarterial

School of Medicine

Professor, Daniel Chang

Chemoembolization (TACE) versus

Department of Radiation

Associate Professor,

Stereotactic Body Radiotherapy

Oncology

Billy Loo

(SBRT) for Recurrent Hepatocellular

Assistant Professor,

Carcinoma after Initial TACE

【Head of the unit】

Maximilian Diehn

・iSABR – Phase II Trial ofProfessor, Quynh-Thu Le

Assistant Professor,

Individualized Lung Tumor

Erqi Pollom

Stereotactic Ablative Radiotherapy(Medical Physics Section)・Research of real-time image guided

Professor, Lei Xing

radiation therapy, proton therapy

Associate Professor,

dosimetry, treatment planning・

Edward Graves

Radiomics and clinical data analysis

Visiting Scholar,・Molecular imaging and molecular

Burcin Unlu

image guided radiation therapy

Visiting Scholar,

・Real time imaging of proton

Hao Peng

therapy

Assistant Professor,

・Radiomics and image analysis

Ruijiang Li
Research Associate, Yi Cui
Postdoctoral Researcher,
Qiong Xu
Postdoctoral Researcher,Jeffrey Wang
(Radiation Biology Section)

・Identify mechanisms by which

Professor, Amato Giaccia

tumor cells survive, recur, andSenior Assistant Professor,

metastasize following radiotherapy

Jin-Min Nam

・Identify mechanisms to protect

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Assistant Professor,

normal tissues from acute and lateErinn Rankintoxicities associated with

Research Fellow, Yu Miao

radiotherapy

Postdoctoral Researcher,・Radiation related vesicle trafficking

Chi-Che Hsiehand exocytosis
・Developing a possible clinicalstrategy for using gold nanoparticles
to breast cancer following
radiotherapy

Organizational Structure of the GSQ (as of March 2018)54

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● Role sharing with affiliated universities(a) Clinical Science Section
The Clinical Science Section has started internationalization of the clinical studies in precision
external radiotherapy conducted by Professor Quynh-Thu Le, Professor Daniel Chang, Associate
Professor Billy Loo, and Assistant Professor Maximilian Diehn at SU. These Professors and clinicalresearch coordinators visited the GI-CoRE and clinical research and development center at Hokkaido
University Hospital before the start of these studies. The role of stereotactic ablative radiotherapy(SABR) in measuring cDNA in the blood, a potentially essential surrogate marker in improving cancer
survival rates for lung cancer has been studied. A randomized clinical trial comparing SABR and thestandard treatment, trans-arterial embolization for relapsed hepatocellular carcinomas has been
conducted by SU. The GSQ has hired clinical research coordinators who are good at English to facilitate
the international clinical trials. All English protocols and informed consents were translated into
Japanese and accepted by the ethics committee of Hokkaido University Hospital. For these two clinicalstudies, the Clinical Science Section has made it possible to register patients treated at Hokkaido
University Hospital into these studies with the great help from staff of clinical research at SU. SU has
worked closely with HU on highly precise radiotherapy such as image guidance and usage of big data to
predict outcomes of cancer treatments. The clinical benefit of proton beam and carbon beam therapies
has been discussed extensively with data from HU and other Japanese institutions which utilize particle
beam therapy. Linking these clinical studies effectively enables clinical research to realize newtreatments aimed at avoiding recurrence and metastasis.
Professor Kohsuke Kudo, Senior Assist. Prof. Noriko Manabe, and Senior Assist. Prof. Khin Khin Tha
from the Clinical Science Section of HU and Professor Lei Xing, Assist. Prof. Ruijiang Li, Research
Associate Yi Cui, post-doctoral researcher Jeffrey Wang from the Medical Physics Section of SU are
conducting collaborative research to identify noninvasive tumor biomarkers through analysis ofmagnetic resonance (MR) images using radiomics, an innovative quantitative image analysis. The firstproject was identification of imaging features to predict the overall survival of glioblastoma patients.
Using MR imaging datasets of glioblastomas, Drs. Cui, Tha, Wang, Kudo, Xing, Shirato, and Li enabled
the extraction of five imaging features, the combination of which predicted the overall survival of
glioblastoma patients with superior performance over existing prognostic indicators (Fig. 4) (Radiology
2016; 278: 546-553). Drs. Cui, Tha, Shirato, and Li further extended the work to identify MR imaging
features which could differentiate glioblastoma molecular subtypes (Fig. 5)  this differentiation isimportant as treatment responses and prognoses varied greatly among the subtypes. Through a few
modifications of the radiomic analytics they developed, the researchers could distinguish the proneuralsubtype of glioblastoma from other molecular subtypes (Eur Radiol 2017; 27: 3583-3592). Using asimilar approach, Drs. Wang, Manabe, Li, Cui, Tha, Kudo, and Shirato also identified MR imaging
features that could differentiate triple-negative breast cancer (PLoS One 2015; 10: e0143308). Currently,
these researchers are working on prediction of hypoxic regions within glioblastomas (Drs. Kudo, Tha,
Cui, and Shirato), and on distinguishing pseudo-progression and pseudo-regression of diffuse gliomas
from true tumor progression and responses (Drs. Tha, Xing, and Shirato), through radiomics and deeplearning analytics of MR images. Hypoxic tumor areas are often resistant to standard doses of radiation
therapy and require adaptation of treatment regimes. Distinguishing pseudo-progression andregression from true tumor progression and response is essential since treatment regimens differ forthese conditions, but the performance of currently available imaging techniques is not satisfactory.

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Fig.4 Kaplan-Meier curves showing the performance of MR

Fig.5 Boxplots showing smaller high-risk volume (HRV) MR

imaging features extracted by radiomic analytics inimages for the proneural glioblastoma molecular subtype (HRV

distinguishing patients based on overall survival period

was derived from the MR images) (Eur Radiol 2017; 27: 3583-(Radiology 2016; 278: 546-553)

3592)(b) Medical Physics Section
The Medical Physics Section and researchers of SU have conducted research to visualize twodimensional (2D) gold concentration distributions in objects by observing the amount of fluorescence Xrays emitted when proton beams collided with gold, using the proton beam line at HU (M. Bazalova etal., Med. Phys. 2015). The team has also been engaging in the development of technology to determine
proton ranges in real-time by observing ultrasonic waveforms emitted from the irradiated target during
treatment (M. Ahmad et al., Med. Phys. 2015). Furthermore, working with Dr. Ruud Vinke, a doubly
appointed Stanford researcher who stayed at HU for three months in 2015, the team developed
technology to enable CBCT acquisition with multiplex X-ray energy levels which is better than theexisting single energy cone beam CT technology. For research into proton beam irradiation technology,
the team also developed a device to decrease duration of irradiation when the target moves due torespiration (T. Matsuura et al., Phys. Med. Biol. 2016). Another SU researcher, Cesare Jenkins, came to
HU and performed the first experimental study of proton range verification using a phosphor coatedphantom and the preliminary data was presented at the 2016 Annual Meeting of AAPM. Anastasia
Makarova, a post-doctoral researcher at HU between 2016 and 2017, worked together with Associate
Professor Taeko Matsuura and Assistant Professor Kenneth Lee Sutherland. They evaluated energy
absorption by bystander gold nanoparticles. Through Monte Carlo simulation, efficiency of electronshielding by tumor-surrounding clusters of gold nanoparticles was examined. The study was presented
at the 2017 Annual Meeting of AAPM. Dr. Hao Peng of SU works in pursuit of several projects together
with Dr. Jeffrey Wang and other HU researchers. With Dr. Peng’s vast experience in PET and MRItechnologies, projects concerning development of detector designs are underway, investigating circuit
multiplexing strategies, signal encoding, and optimization of systems using machine learning techniques.
Dr. Peng also has been investigating characterization of a new imaging technique to improve accuracyof breast cancer diagnosis with Dr. Wang. The X-ray-induced acoustic (XA) imaging technique (pioneeredby Prof. Lei Xing) has shown great promise as a technique able to produce tomographic images as wellas act as a method of radiation therapy dose calculation. Dr. Peng was awarded a 3-year Grant-in-Aid

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for Young Scientists from the Japan Society for the Promotion of Science (JSPS) which started in 2017,
to develop a system to hybridize breast tomosynthesis and XA to improve diagnostic accuracy of
mammography (Fig. 6). Specifically, the project aims to develop a comprehensive framework tocharacterize the performance of such a system, with respect to image quality and detection limit, as wellas to build a prototype to demonstrate feasibility through phantom and in-vivo animal studies. Dr. Qiong
Xu of SU visited between 2016 and 2018, during which time she advanced to become Assist. Prof. of HU.
She has been investigating reconstruction of low-dose thoracic CT using dictionary learning of regionspecific structures within organ compartments. The strategy successfully takes into account inherent
regional differences inside reconstructed objects and lead to improved images. The results of this study
have been submitted to the IEEE’s Transactions on Medical Imaging (Fig. 7). Dr. Xu is currently working
on a deep learning-based method of CT reconstruction with Dr. Wang. The technique exploits a deep
convolutional decoder-encoder network learned prior to restore images corrupted by metal artifacts. The
initial study has been submitted to at the 2018 Annual Meeting of AAPM. Dr. Mehmet Burcin Unlu is
the latest scholar to visit from SU, an expert in the topics of photoacoustic imaging and inverse problems,
also pursuing interests in radiation-induced acoustic imaging. At first, evaluation of an analytical model
for acoustic signal induction is being performed against simulations and has been submitted to AAPM
2018. Several projects involving characterizing proton beam- and X-ray- induced acoustics
experimentally are also underway.

Fig.6 (a) Schematic drawing of a hybrid X-ray induced acoustic breast imaging system (not to scale). (b) The
penetration depth of X-ray in different energies vs. the penetration depth of ultrasound wave in different
frequencies, which are much larger compared to optical photons. (c) The acoustic signal emission from thetarget hit by a pulsed X-ray allows for 3D volumetric imaging (Xing et al., Scientific Reports 2016).

Fig. 7 Learned dictionaries for region-specific low-dose CT reconstruction (bottom) and their represented
regions (top). The 1st column at left corresponds to the thorax region mask and represents the conventional
single dictionary. The 2nd-5th columns are the lung, heart, surrounding tissue, and juncture region masks
respectively, corresponding to the respective region-specific dictionaries (submitted by Xu et al., IEEE TMI2018).

.

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(c) Radiation Biology Section
Since 2014, the Radiation Biology Section has worked to develop a work environment, including wetlaboratory space, an office, and research facilities on the 4th floor of the Graduate School of Medicine of
HU that enables carrying out of collaborative radiation biology research between SU and HU. The
research of the Radiation Biology Section led by Professor Amato J. Giaccia of SU, and the teamincluding Senior Assist. Prof. Jin-Min Nam, Assist. Prof. Erinn B. Rankin, research fellow Yu Miao, andpost-doctoral researchers Frances C. Recuenco and Chi-Che Hsieh have conducted several collaborative
research projects at HU. The team has been focused on investigating the molecular mechanism ofradiation effects to improve the efficacy of radiation treatment on cancer cells.
Dr. Giaccia has given three state-of-the-art special lectures on radiation biology and the tumor
microenvironment at the annual GI-CoRE International Symposium. For education of students, Dr.
Giaccia and Dr. Le will give a lecture series on radiation biology in the Hokkaido Summer Institute2018/ GI-CoRE Summer School for Radiation Biology 2018. Dr. Nam has been giving lectures andresearch training to graduate students at HU of the Graduate School of Medicine and Graduate Schoolof Biomedical Science and Engineering. Drs. Rankin and Miao gave talks at the annual GI-CoRE
International Symposium. The SU members stayed and conducted discussions with lab members at HU.
In educational activities, under the supervision of Dr. Nam, Ping-Hsiu Wu (M.D.), a graduate studentof the Graduate School of Medicine of HU, is engaged in research related to the application of sensitizers
targeting certain cell surface receptors which regulate cancer cell invasion. Dr. Wu presented theresearch at several international conferences: The ASCB Annual Meeting (San Diego, 2015), The 3rd
GI-CoRE Medical Science and Engineering Symposium (Sapporo, 2016), ASTRO (Boston, 2016), JCA(Yokohama, 2016), JASTRO (Osaka, 2017), and AACR 2018 (Chicago, 2018) sponsored by Drs. Giaccia
and Le. Dr. Wu also visited the laboratories of Drs. Giaccia and Graves at SU to learn how to conduct invivo experiments in mice. By the supervision of Dr. Nam and Dr. Giaccia, Dr. Wu published work about
gold
nanoparticles
andradiation
sensitization in the International Journalof Nanomedicine (Wu et al., Int J
Nanomedicine, 2017, Fig.8). Dr. Recuenco
has mastered the experimental system ofin vivo imaging to analyze the effects ofradiation using animal models. Dr.
Recuenco provided training in animal
work for students and technicians. The
Fig.8 RGD-conjugated gold nanoparticles in radiotherapy
project of carrageenan, a natural seaweed
polysaccharide, as an adjuvant inradiation therapy has been conducted by Drs. Recuenco, Hsieh, and Wu. They are writing up a
manuscript with in vitro and in vivo results that λ-carrageenan improves the efficacy of radiation
treatment of cancer cells. Dr. Hsieh has mainly been conducting the project on the CD44 variant inradioresistance.
In addition to the original work, researchers of the GSQ Stanford University unit have been actively
collaborating with other faculty groups in the Graduate School of Medicine to understand the molecularmechanisms of cancer cell invasion (Hashimoto et al., J Cell Biol., 2016; Cell Commun Signal., 2016),
Nik-related kinase signaling on placental development (Morioka et al., PLoS One, 2017), and cellcompetition (Kon et al., Nat Cell Biol., 2017). The GSQ Stanford University unit has also been working
with an immunologist in collaborative research showing that the Toll-like receptor 3 signal augments
radiation-induced tumor growth retardation in a murine model (Yoshida et al., Cancer Sci., 2018). Drs.
Le, Giaccia, Koong, and Shirato have put together a review on an emerging treatment paradigm inradiation oncology in the prestigious American Association for Cancer Research journal (Le QT et al.,58

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A

Clin Cancer Res 2015). Drs. Rankin, Nam, and Giaccia also published a review of Hypoxia andmetastatic cascade (Rankin et al. Trends Cancer, 2016).
● Role sharing between faculty members at HU(a) Clinical Science Section
At the Clinical Science Section, Professor Hiroki Shirato has published summaries of the GI-CoRE
4th and 5th symposium with the co-editor Prof. Quynh-Thu Le of SU in a special edition of the Journalof Radiation Research, the official journal of the Japanese Society of Radiation Oncology (JASTRO).
The aim of the symposium was to establish international consensus in the way to select external
radiotherapy technology for individual patients and featured lecturers from the Netherlands, USA,and Japan. The special issue contains all peer-reviewed papers including those from distinguishedresearchers such as the Mayo Clinic, the MD Anderson Hospital, and the National Institute forRadiological Science in addition to HU and SU. Drs. Shirato, Le, and other professors at HU and SU
have published a keynote review for this issue. A consensus statement from all of the speakers in the
symposium has been published in the journal. Professor Shinichi Shimizu has led research to develop
state-of-the-art, minimally invasive, advanced radiotherapy technology using proton beam therapy. Dr.
Shimizu has published papers and made presentations at academic conferences related to thedevelopment of proton beam therapy with real-time tumor tracking technology and numericalsimulations of clinical applications. Assistant Prof. Tetsuya Inoue has started two international clinicalstudies to measure cDNA (cancer cell genes in the blood) conducted by Assist. Prof. Maximilian Diehn
at SU to improve survival rates of lung cancer. Assistant Prof. Norio Katoh and Senior Assist. Prof.
Daisuke Abo, have become involved in the randomized trial conducted by Professor Daniel Chang at
SU to compare the effect of stereotactic ablative body radiotherapy (SABR) with the standard
treatment, intra-arterial embolization, for relapse of hepatocellular carcinomas. Dr. Abo studied at
Stanford University Hospital for 3 months before the start of this study. These two international
collaborative studies have been successful in recruiting patients from Japan to studies in the USA
making the value of the studies international. Assist. Prof. Kentaro Nishioka has analyzed clinicalresults of real-time-image gated proton therapy (RGPT) and published the results. Senior Assist. Prof.
Noriko Manabe has developed innovative quantitative image analysis technology for cardiac imaging
with international colleagues.
Drs. Kudo and Tha have recently initiated a collaboration with Professor Miki Haseyama of the
Graduate School of Information Science and Technology, who also belongs to the Global Station for Big
Data and Cybersecurity (GSB), to develop a system that would allow automatic detection of small
brain metastases. Development of such a system would be helpful in reducing the workload ofradiologists involved in identifying these lesions from hundreds of images and also increase thediagnostic accuracy. Promising preliminary results have been obtained (Sugata et al., A note on theclassification of brain metastases from MR images based on machine learning), and the researchers
are currently planning to proceed with data analysis by incorporating larger volumes of image data.
Members of the GSQ and Drs. Yasuda, Kudo, and Haseyama of GSB are planning to evaluate whether
the system would also allow automatic detection of vertebral metastases. As a separate project, Drs.
Tha and Manabe have initiated research to determine the usefulness of electric properties tomography
 a new MR imaging technique, in evaluations of lung and liver tumors. Drs. Tha, Kudo, and Shirato
have previously explored the role of this imaging technique in evaluations of brain tumors andobserved that electrical conductivity measurable by this technique can differentiate glioblastomas
from lower grade gliomas (Eur Radiol 2018; 28: 348-355). Dr. Wang of the Medical Physics Section iscurrently investigating multiparametric MRI, especially using new machine learning techniques, fordiagnosis of breast cancer and prognosis of its treatment therapy with Dr. Manabe. Incorporation of
the advanced Diffusion Kurtosis Imaging method, already shown to increase diagnostic specificity
significantly, is expected to improve upon current models of predicting breast cancer outcomes with59

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the radiomics approach. Along with Dr. Tha, Dr. Wang is also studying diagnosis of early Parkinson’s
Disease and prognosis in brain tumor radiotherapy using deep generative neural network learning of
biomarkers seen on Diffusion Tensor Imaging.
(b) Medical Physics Section
The Medical Physics Section has worked on developing new technology to improve the treatment
accuracy of proton therapy, something that has attracted a great deal of public attention in recent
years. Assoc. Prof. Taeko Matsuura of HU and Instructor Magdalena Bazalova (currently serving as
an Assistant Professor at University of Victoria）developed technology to depict and outline the twodimensional gold concentration distributions in objects using the proton beam therapy system of HU(M. Bazalova et al., Med. Phys. 2015). Many specialists have pointed out the importance of developing
technology to verify the proton beam range during treatment, and the team led by Dr. Matsuura andpost-doctoral researcher Moiz Ahmad at SU has engaged in developing technology to determine therange of the proton beam in real-time using ultrasonic waveforms emitted by the irradiated target
during treatment (M. Ahmad et al., Med. Phys. 2015). Since 2015, a team led by Assist. Prof. Seishin
Takao, Professor Kikuo Umegaki, and post-doctoral researcher Ruud Vinke, who joined HU for threemonths, has been engaging in the development of technology to make it easier to acquire CBCT withmultiplex X-ray energy levels compared to the existing single energy approach. We can expect that
this technology will improve resolution of obtained CT images and enable more accurate calculationsof dose. The Matsuura team has also developed a device to decrease duration of irradiation needed
when the target moves due to respiration (T. Matsuura et al., Phys. Med. Biol. 2016). In addition tothese research activities, as previously mentioned in the Clinical Science Section, researchers in
Medical Physics Section, Assist. Prof. Ruijiang Li who spent 6 months at HU and post-doctoral
researcher Yi Cui (currently serving as a Research Associate at SU) who spent 12 months in the GSQ
at HU, performed radiomics studies using the clinical imaging data of brain and pancreatic tumors
treated at SU and HU. They published their results in the top journal in this field (Radiology, 2015).
Professor Masayori Ishikawa and Assist. Prof. Kenneth Lee Sutherland at HU are engaging in thesummer school sessions at HU as a part of the global educational outreach in collaboration with SU.
With the growing presence of artificial intelligence, in efforts described above and all other industries,
the GSQ, Global Station for Big Data and Cybersecurity (GSB), and the Institute for Genetic Medicine(IGM), held a joint symposium in July 2017. Topics of quantum science, informatics, biology, medicine,and the emerging “Internet of Things” were covered between interdisciplinary experts, spurring many
discussions and further initiating collaborative efforts. Drs. Matsuura and Takao have investigated
the impact of real-time image gating on spot scanning proton therapy for lung tumors, throughsimulation. For the purpose of studying the effectiveness of real-time image gated proton beam therapy
for lung tumors, a novel respiratory model was developed employing 4DCT to express regularvolumetric variations of respiration (Fig. 9, T. Kanehira et al., Intl. Journal of Rad. Onc. Bio. Phys.
2017). They have also developed an analytical dose-averaged-linear energy transfer (LETd)-calculation
algorithm, which considers off-axis enhancement by secondary protons in proton therapy to evaluate
the biological effects of proton beams as part of daily clinical routine. Large improvements of LETd
accuracy were seen compared with the previous analytical approach based on the pencil-beamalgorithm. This work has been submitted to Medical Physics. Dr. Kanehira, a graduate of HU, iscurrently visiting the Netherlands Institute for Cancer as a post-doctoral researcher investigating
image-guided radiotherapy using MRI. Under the supervision of Drs. Matsuura, Makarova, Peng,
Umegaki, and Shirato, Jihun Kwon, a student of HU’s Graduate School of Medicine evaluated theenergy absorption of gold nanoparticles (GNP). This work was presented at the 2017 annual meeting60

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of AAPM. Mr. Kwon is currently on
a one-year visit to the Dana-Farber
Institute of Brigham and Women’s
Hospital and Harvard Medical
School. With local experts in the useof GNP, he conducts research
investigating them as a vascular
disrupting agent, focusing on amethod to non-invasively quantify a“signature” of the disruption using
ultrasound and MRI. In parallel, healso investigates prediction oftreatment
outcomeusing
microvascular imaging. The firstpresentation of the work waspresented at the North Englandchapter of AAPM 2018.
In addition to these original works, researchers of the GSQ Hokkaido University unit have been
actively collaborating with otherfaculty groups in the Graduate
Fig. 9 Study workflow for the 4-dimensional dose calculation in studying
School of Medicine to develop
impact of real-time image gating on spot scanning proton therapy for lungquantitative imaging techniques
tumors (Kanehira et al. 2017)
and the radiomics approach of data
analysis. The details of these collaborative works and the publications to which they led have been
listed above in the Clinical Sciences Sections.
(c) Radiation Biology Section
For the collaborative project in radiation biology, a numberof studies with different themes have been conducted to findnovel molecular targets to improve the efficacy of radiation
therapy with the faculty of HU and the GSQ Stanford
University unit. The collaborative team focused on vesiculartrafficking of cell-surface receptors, cancer stemness, immune
responses, and the extracellular microenvironment. The
collaborative studies including experiments have mainly been
conducted by postdoctoral fellows, graduate students, andtechnicians of HU in the lab of the Graduate School of
Medicine under supervision of SU members, Faculty membersof HU and the GSQ Stanford University unit. To conduct thecollaborative research, Senior Assist. Prof. Yasuhito Onodera
and Dr. Nam installed a 200 m2 laboratory for radiation
biology in 2014 (Fig.10). Faculty members of HU and SU have
set up the in vivo imaging work equipment in the animal
facility of the Faculty of Medicine (Fig. 11).

Fig.10 Set-up of the laboratory for biology

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Dr. Onodera has been in discussions with members of the GSQ Stanford University unit and fellows
about education and collaboration in research. Dr.
Onodera has also been working with Drs. Shirato andNam on a project of mitochondrial dynamics and cancer
invasion (Onodera et al., Nature communications, 2018,
Accepted).
Assist. Prof. Koichi Yasuda visited the Rankin lab at SU
for five months in 2015 to carry out collaborative
research focusing on enhancing tumor radiosensitivity.
For education of undergraduate and graduate students,
faculty members of the GSQ have been organizing a
Fig. 11 In vivo Imaging
monthly journal club with the topics of radiation biology
in English. In addition, faculty members at HU havebeen teaching graduate HU students of the Graduate School of Medicine and the Graduate School of
Biomedical Science and Engineering. They will hold the Hokkaido Summer Institute/GI-CoRE
Summer School for Radiation Biology in 2018.
● Future developments
The Clinical Science Section has consisted of radiation oncology and radiomics groups. In parallelwith the rapid progress seen with machine learning and artificial intelligence (AI) across other fields
as well as precision medicine, the radiomics group will be separated from the Clinical Science Section
and be set up as a new unit for AI with a part of the Medical Physics Section. Here, data-driven modelbased approaches to select appropriate external radiotherapy techniques will be studied using
biomarkers in silico, such as in the case of normal tissue complication probability (NTCP) models. In
the radiation oncology group, the benefit of particle beam therapy will be studied with both patients
at HU as well as at other institutions using the national database for particle beam therapy.
International clinical studies will be expanded from HU and SU to include institutions in othercountries such as in Thailand and Singapore.
Going forward, along with the currently stationed Dr. Unlu, SU and HU researchers continue theefforts of GSQ medical physics developments to study topics aforementioned toward development ofnovel imaging techniques, developing and characterizing impact of new radiation and proton therapy
techniques, as well as investigate novel methods of image reconstruction. In February 2018, anInternational Seminar on Radiation Oncology was held in Niseko, Japan. Drs. Xing of SU, Shirato andShimizu of HU, as well as other attendees such as Dr. David Grosshans of the MD Anderson Cancer
Center discussed the future of the Medical Physics Section. In parallel with its growth, the numerous
efforts of the GSQ warrant some specialization of research interest groups. As mentioned above, a new
AI and Big Data group for precision medicine is planned, as many projects now include the use ofmachine learning in analyzing increasingly complex data, a trend seen across all fields. Symposiums
to showcase such efforts for education, as well promote discussion and collaboration, are also planned.
The Radiation Biology Section of the GSQ has invited the same section from SU and started advanced
research with Faculty of HU on the topic, which is aimed at and will lead to the development of novel
cancer therapies. It has been accelerating international collaborative research through its closeinteraction with SU and presented research results at international conferences and published papers
using the research resources of both institutions until FY2017. Based on the achievements, theRadiation Biology Section will further develop research related to radiation sensitizers andunderstanding of molecular mechanisms of cancer cell invasion after radiation treatment. Throughthe collaborative research, the Radiation Biology Section will give advanced education and researchtraining to graduate students in the Graduate School of Biomedical Science and Engineering, which
was established in April 2017. In the school, students have the opportunity for training in the Cell

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Processing Center at Hokkaido University Hospital to obtain qualifications as ‘Clinical Cultivatist’
from The Japanese Society for Regenerative Medicine.
② International Collaborative Research● Current progress in meeting initial research goals(a) Clinical Science Section
We have conducted international collaborative research in the Clinical Science Section between HU
and SU as follows.
a. International clinical trials
a-1. Phase II trial of individualized lung tumor stereotactic ablative radiotherapy (iSABR) P.I. Maximilian
Diehn, and Billy Loo, M.D., Ph.D. (Fig. 12)
An official agreement was reached, as of September 1, 2015, by and between Hokkaido
University and the BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR
UNIVERSITY, a body having corporate powers under the laws of the State of California forthis International Multi-Site Clinical Trial.
From Hokkaido University, three patients have been successfully registered up to March 2018.

Fig.12 Schema of Phase II trial of individualized lung tumor stereotactic ablative radiotherapy (iSABR).

a-2. International Randomized Study of Transarterial Chemoembolization (TACE) versus
Stereotactic Body Radiotherapy (SBRT) / Stereotactic Ablative Radiotherapy (SABR)
for Residual or Recurrent Hepatocellular Carcinomas after Initial TACE. P.I. Daniel
Chang, Protocol Number: IRB-35937 (Fig. 13)
From Hokkaido University, one patient has been successfully registered up to March
2018.

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Residual or recurrent HCC disease following TACE
160 Total Subjects

Randomize (stratified by tumor size ≤ 3 cm vs > 3 cm

TACE

SABR

80 Subjects

80 Subjects

Fig.13 Schema of International Randomized Study of Transarterial Chemoembolization (TACE) versus

Stereotactic Body Radiotherapy (SBRT) / Stereotactic Ablative Radiotherapy (SABR) for Residual or
Recurrent Hepatocellular Carcinomas after Initial TACE.

b.

Radiomics
A biomarker has been developed by Dr. Li of SU in collaboration with Dr. Tha based onradiomics. Dr. Cui, started working as a post-doctoral researcher of the GSQ and currently
holds a double appointment between SU and HU, started clinical data analysis with Dr. Li of
SU who has also once been hired at the GI-CoRE.
b-1. Glioblastomas
1. Cui Y, Tha KK, Terasaka S, Yamaguchi S, Wang J, Kudo K, Xing L, Shirato H, Li
R. Prognostic Imaging Biomarkers in Glioblastoma: Development andIndependent Validation on the Basis of Multiregion and Quantitative Analysis of
MR Images. Radiology. 2016 Feb;278(2):546-53. doi: 10.1148/radiol.2015150358.
2. Cui Y, Ren S, Tha KK, Wu J, Shirato H, Li R. Volume of high-risk intratumoral
subregions at multi-parametric MR imaging predicts overall survival andcomplements molecular analysis of glioblastoma. Eur Radiol. 2017
Sep;27(9):3583-3592. doi: 10.1007/s00330-017-4751-x
b-2. Breast cancer
1. Wang J, Kato F, Oyama-Manabe N, Li R, Cui Y, Tha KK, Yamashita H, Kudo
K,Shirato H. Identifying Triple-Negative Breast Cancer Using Background
ParenchymalEnhancement Heterogeneity on Dynamic Contrast-Enhanced MRI:
A Pilot Radiomics Study. PLoS One. 2015 Nov 24;10(11):e0143308. doi:
10.1371/journal.pone.0143308.
2. Wang J, Kato F, Yamashita H, Baba M, Cui Y, Li R, Oyama-Manabe N, Shirato
H.Automatic Estimation of Volumetric Breast Density Using Artificial Neural
Network-Based Calibration of Full-Field Digital Mammography: Feasibility on
Japanese Women With and Without Breast Cancer. J Digit Imaging. 2017. doi:
10.1007/s10278-016-9922-9
3. Wu J, Sun X, Wang J, Cui Y, Kato F, Shirato H, Ikeda DM, Li R. Identifying
relations between imaging phenotypes and molecular subtypes of breast cancer:
Model discovery and external validation. J Magn Reson Imaging. 2017
Oct;46(4):1017-1027. doi: 10.1002/jmri.25661.

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c.

Overview of radiotherapy
Based on the discussion at the GI-CoRE symposium, HU and SU have written a review article
about the state-of-art of radiotherapy and the selection of external beam radiotherapies for
precise and accurate cancer treatments.
1. Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation
Oncology. Clin Cancer Res. 2015 Aug 1;21(15):3393-401. doi: 10.1158/1078-0432.CCR14-1191.
2. Shirato H, Le QT, Kobashi K, Prayongrat A, Takao S, Shimizu S, Giaccia A, Xing L,
Umegaki K. Selection of external beam radiotherapy approaches for precise andaccurate cancer treatment. J Radiat Res. 2018 Jan 24. doi: 10.1093/jrr/rrx092(b) Medical Physics Section
We have conducted international collaborative research in the Medical Physics Section between HU
and SU as follows.
a. Several novel imaging techniques are being investigated, including proton-induced X-ray
fluorescence CT, X-ray-induced acoustic imaging, and Multi-energy Cone Beam CT.
1. Bazalova-Carter M, Ahmad M, Matsuura T, Takao S, Matsuo Y, Fahrig R, Shirato H,
Umegaki K, Xing L: "Proton-induced x-ray fluorescence CT imaging.", Med Phys., 2015
Feb;42(2):900-7 (2015)
2. 3-year Kakenhi Grant-in-Aid for Young Scientists from the JSPS awarded to Dr. HaoPeng toward “Development of a hybrid tomosynthesis and acoustic imaging modality
for early detection of breast cancer.”
3. 2-year Kakenhi Grant-in-Aid for Young Scientists from the JSPS awarded to Dr. Jeffrey
Wang toward “Development of an acoustic imaging modality for absolute and real-time
radiotherapy dosimetry.”b. Developments concerning characterization of the impact of novel radiation and proton therapy
techniques are also underway in parallel, including use of acoustics methods for range
verification, devices to decrease duration of irradiation during movement, real-time image
gating on spot scanning proton therapy, analytical models of dose-averaged-linear energy
transfer, phosphor-coated phantoms, and gold nanoparticles.
1. Ahmad, M., Xiang, L., Yousefi, S., & Xing, L. (2015). Theoretical detection threshold of
the proton-acoustic range verification technique. Medical Physics, 42(10), 5735–5744.
2. Matsuura T, Fujii Y, Takao S, Yamada T, Matsuzaki Y, Miyamoto N, Takayanagi T,
Fujitaka S, Shimizu S, Shirato H: "Development nd evaluation of a short-range
applicator for treating superficial moving tumors with respiratory-gated spot-scanning
proton therapy using real-time image guidance.", Phys Med Biol., 61(4):1515-31 (2016)
3. Kanehira, Matsuura, Takao et al., "Impact of Real-Time-Image gating on Spot Scanning
Proton Therapy for Lung Tumors: A Simulation Study," International Journal of
Radiation Oncology Biology Physics 97.1 (2017): 173-181.
4. Hirayama, Matsuura, Ueda et al., "An Analytical Dose-Averaged LET-Calculation
Algorithm Considering the Off-Axis LET Enhancement by Secondary Protons for SpotScanning Proton Therapy," Med. Phys. submitted (2018)65

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(c) Radiation Biology Section
International collaborative research in radiation biology has been conducted between HU and SU tofind novel molecular targets and radiation sensitizers to improve the efficacy of radiation therapy.
1. RGD-conjugated gold nanoparticles (AuNPs) in radiotherapy decrease the invasive activity ofbreast cancer cells: The work has been conducted mainly at HU (Drs. Nam, Onodera, and Shirato) bycollaboration with SU (Drs. Rankin and Giaccia) and companies (Aisin Seiki Co., Ltd., Aichi, Japanand IMURA America, Inc., Ann Arbor, MI). The study suggests that RGD/P-AuNPs can target
integrin-overexpressing cancer cells to improve radiation therapy by suppressing invasive activity inaddition to providing sensitization. The findings provide a possible clinical strategy for using AuNPs
to treat invasive breast cancer following radiotherapy. Further studies are needed for a detailed
understanding of the molecular mechanism. (Fig. 14)
B

A

Fig.14 (A)Schematic diagram of RGD/P-AuNPs. (B) Dark-field TEM image of synthesized AuNPs.

● Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T,
Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles inradiotherapy decreases the invasive activity of breast cancer cells. Int J Nanomedicine. 2017 Jul
14;12:5069-5085. doi: 10.2147/IJN.S137833.
2. Radiation increases the invasive activity of breast cancer cells by altering the lysosome exocytosis:
To find novel molecular targets and understand the mechanism of the activity, the exocytosis pathway
in cells has been analyzed by Dr. Wu under supervision of staff at HU and SU, Drs. Shirato, Nam,
Onodera, Giaccia, and Le. Dr. Wu, a graduate student at HU, found that radiation enhances lysosome
exocytosis in breast cancer cells, an activity that can lead to increases in the invasive activity. The
work will focus on providing details of a novel mechanism to understand cancer invasion afterradiotherapy and suggest novel approaches to counteract this undesirable effect of radiotherapy.

● Wu PH, Onodera Y, Giaccia AJ, Le QT, Shirato H, Nam JM. Radiation increases invasive activityof breast cancer cells via altering lysosome exocytosis. AACR Annual Meeting 2018. Chicago,
2018. 4. 14-18.
3. Carrageenan as an adjuvant to improve radiotherapy: To identify radiation sensitizing compounds,
HU and SU researchers paid attention to carrageenan, a family of linear sulfated polysaccharides.
(Drs. Recuenco, Hsieh, Wu, Onodera, Giaccia, Le, Shimizu, Shirato, and Nam) The combined treatmentof radiation and carrageenan significantly reduces lung metastasis in a 4T1 xenograft model of murine
mammary cancer. The results of the work will potentially provide a therapeutic strategy withcarrageenan as an adjuvant for radiotherapy.

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● Hsieh CC*, Wu PH*, Recuenco FC, Onodera Y, Sasaki N, Giaccia AJ, Le QT, Shimizu S, Shirato
H, Nam JM. Carrageenan as an adjuvant to improve radiotherapy via reducing the metastatic
potential of breast cancer. *Equal contributions (Manuscript under preparation)● Research results (FY 2014-2018)
As of April 2018
1. International collaborative

Featured in Japanese journals: 5, featured in overseas journals: 29

papers (peer reviewed)
2. Other publications

Featured in Japanese journals: 48, featured in overseas journals: 132,
books published: 1

3. Verbal presentations

Keynote speeches:7, invited lectures:86 (Japanese 70, International
16)
other presentations: 111 (Japanese 85, International 26)

4. Patent applications

Registered patents: 14 (8 in Japan, 6 overseas)
Pending patents:

5. Awards received

11

6. External grants

5

1 (0 in Japan, 1 overseas)

1) International collaborative papers (peer reviewed)- Journals published by Japanese publishers, including those published in English, are listed as "Japanese journals".
- Papers where "GI-CoRE" is stated as an affiliated institution of a Japanese or overseas researcher, or thosementioning "Hokkaido University " in the acknowledgements, are marked with a "* (asterisk)" and the applicable
author name is underlined.
- Among the papers with "* (asterisk)", papers where "GI-CoRE" is stated as an affiliated institution are marked
with "i)", and papers which mention "Hokkaido University" in the acknowledgements are marked with "ii)".
- Papers where GI-CoRE researchers of Hokkaido University and Stanford University are stated are marked with"○".
(1) Le QT, Shirato H. Preface. J Radiat Res. 2018 Mar 8. doi: 10.1093/jrr/rry015. [Epub ahead ofprint] PubMed PMID: 29528445 (2018) [Japanese journal] ○(2) Shirato H, Le Q-T, Kobashi K, Prayongrat A, Takao S, Shimizu S, Giaccia A, Xing L, Umegaki K:“Selection of external beam radiotherapy approaches for precise and accurate cancer treatment”,
J Radiat Res. Vol. 59, Issue suppl_1, 1 March 2018, i2-i10 (2018) [Japanese journal] *i) ○(3) Wu J, Tha KK, Xing L, and Li R: “Radiomics and radiogenomics for precision radiotherapy,” J
Radiat Res. DOI: 10.1093/jrr/rrx102 Published: 27 January (2018) [Japanese journal]*i) ○(4) Toesca DAS, Ibragimov B, Koong AJ, Xing L, Chang DT, Koong AC: “ Strategies for Prediction
and Mitigation of Radiation-Induced Liver Toxicity”, J Radiat Res. (2017) Volume 59, Issue
suppl_1, 1 March 2018, Pages i40-i49 (2018) [Japanese journal](5) Prayongrat A, Umegaki K, Schaaf A, Koong AC, Lin SH, Whitaker T, McNutt T, Matsufuji N,
Graves E, Mizuta M, Ogawa K, Date H, Moriwaki K, Ito YM, Kobashi K, Dekura Y, Shimizu S,
Shirato H: “Present developments in reaching an international consensus for a model-based
approach to particle beam therapy”, J Radiat Res. Vol. 59, Issue suppl_1, 1 March 2018, i72-i76(2018) [Japanese journal] *i) ○67

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(6) Uluc N, Unlu MB, Gulsen G, Erkol H, "An extended photoacoustic transport model forcharacterization of red blood cell morphology in microchannel flow", accepted, Biomedical Optics
Express, 2018. [Overseas journal](7) Nakagawa D, Kudo K, Awe O, Zanaty M, Nagahama Y, Cushing C, Magnotta V, Hayakawa M,
Allan L, Greenlee J, Awad I,Carroll T, Torner J, Raghavan ML, Hasan DM: “Detection of
Microbleeds Associated with Sentinel Headache Using MRI Quantitative Susceptibility Mapping:
Pilot Study”, Journal of Neurosurgery , 2018 In press (2018) [Overseas journal](8) Tha KK, Katscher U, Yamaguchi S, Stehning C, Terasaka S, Fujima N, Kudo K, Kazumata K,
Yamamoto T, Van Cauteren M, Shirato H: “Noninvasive electrical conductivity measurement by
MRI: a test of its validity and the electrical conductivity characteristics of glioma”, Eur Radiol.
2018 Jan;28(1):348-355 (2018) [Overseas journal] *i)(9) Nishikawa Y, Yasuda K, Okamoto S, Ito YM, Onimaru R, Shiga T, Tsuchiya K, Watanabe S,
Takeuchi W, Kuge Y, Peng H, Tamaki N, Shirato H: “Local relapse of nasopharyngeal cancer andVoxel-based analysis of FMISO uptake using PET with semiconductor detectors”, Radiat Oncol.
2017 Sep 6;12(1):148. doi: 10.1186/s13014-017-0886-9 (2017) [Overseas journal] *i) ○(10) Wang J, Kato F, Yamashita H, Baba M, Cui Y, Li R, Oyama-Manabe N, Shirato H: “Automatic
Estimation of Volumetric Breast Density Using Artificial Neural Network-Based Calibration of
Full-Field Digital Mammography: Feasibility on Japanese Women With and Without Breast
Cancer”, J Digit Imaging, 2017 Apr;30(2):215-227. doi: 10.1007/s10278-016-9922-9 (2017)[Overseas journal] *i) ○(11) Sugimori H, Fujima N, Suzuki Y, Hamaguchi H, Ishizaka K, Kudo K: “Fast acceleration of ASLbased time-resolved magnetic resonance angiography by acquisition of control and labeled images
in the same shot (fast ACTRESS): An optimization study”, Magn Reson Imaging., 2017 Jul
25;43:136-143. doi: 10.1016/j.mri.2017.07.026 (2017) [Overseas journal](12) Chang, J. Y., Zhang, X., Knopf, A., Li, H., Mori, S., Dong, L., Lu, H-M., Liu, W., Badiyan, S. N.,
Both, S., Meijers, A., Lin, L., Flampouri, S., Li, Z., Umegaki, K., Simone, C.B 2nd, Zhu XR:, X. R:“Consensus Guidelines for Implementing Pencil-Beam Scanning Proton Therapy for Thoracic
Malignancies” on Behalf of the PTCOG Thoracic and Lymphoma Subcommittee Int J Radiat Oncol
Biol Phys. 2017 Sep1 99(1), 41-50. doi: 10.1016/j.ijrobp.2017.05.014 (2017) [Overseas journal](13) Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T,
Shirato H, Nam JM: “Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy
decreases the invasive activity of breast cancer cells”, Int J Nanomedicine. 2017 Jul 14;12:50695085. doi: 10.2147/IJN.S137833 (2017) [Overseas journal] *i) ii) ○(14) Li B, Cui Y, Diehn M, Li R: “Development and Validation of an Individualized Immune
Prognostic Signature in Early-Stage Nonsquamous Non–Small Cell Lung Cancer”, JAMA Oncol.
2017 Nov 1;3(11):1529-1537. doi: 10.1001/jamaoncol.2017.1609 (2017) [Overseas journal] *i) ○(15) Cui Y, Li B, Li R: “Decentralized Learning Framework of Meta-Survival Analysis for Developing
Robust Prognostic Signatures”, JCO Clinical Cancer Informatics, DOI: 10.1200/CCI.17.00077
published online November 1 (2017) [Overseas journal] *i) ○(16) Cui Y, Ren S, Tha KK, Wu J, Shirato H, and Li R: "Volume of high-risk intratumoral subregions
at multi-parametric MR imaging predicts overall survival and complements molecular analysis ofglioblastoma", Eur Radiol. 2017 Sep;27(9):3583-3592. doi: 10.1007/s00330-017-4751-x. Epub 2017
Feb 6 (2017) [Overseas journal] *i) ○(17) Wu J, Sun X, Wang J, Cui Y, Kato F, Shirato H, M D, Ikeda, Li R: “Identifying Relations Between
Imaging Phenotypes and Molecular Subtypes of Breast Cancer: Model Discovery and External
Validation,” J Magn Reson Imaging. 2017 Oct;46(4):1017-1027. doi: 10.1002/jmri.25661. Epub
2017 Feb 8 (2017) [Overseas journal] *i) ○(18) Homma T, Manabe O, Ichinokawa K, Yamashita H, Oyama-Manabe N, Kato F, Hirata K,
Kroenke M, Tamaki N: “Breast cancer detected as an incidental finding on 99mTc-MIBI

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scintigraphy”,
Acta
Radiol
Open.
2017
Jul
25;6(7):2058460117715665.
doi:
10.1177/2058460117715665 (2017) [Overseas journal](19) Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS,
D'Agostino RB, Wolf PA, Vasan RS, DeCarli C, O'Donnell CJ, Seshadri S: “Association ofdescending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The
Framingham Heart Study”, Atherosclerosis, 2017 Jun 23. pii: S0021-9150(17)31168-1. doi:
10.1016/j.atherosclerosis.2017.06.919 (2017) [Overseas journal](20) Kon S, Ishibashi K, Katoh H, Kitamoto S, Shirai T, Tanaka S, Kajita M, Ishikawa S, Yamauchi
H, Yako Y, Kamasaki T, Matsumoto T, Watanabe H, Egami R, Sasaki A, Nishikawa A, Kameda I,
Maruyama T, Narumi R, Morita T, Sasaki Y, Enoki R, Honma S, Imamura H, Oshima M, Soga T,
Miyazaki JI, Duchen MR, Nam JM, Onodera Y, Yoshioka S, Kikuta J, Ishii M, Imajo M, NishidaE, Fujioka Y, Ohba Y, Sato T, Fujita Y: “Cell competition with normal epithelial cells promotes
apical extrusion of transformed cells through metabolic changes”, Nat Cell Biol. 2017
May;19(5):530-541. doi: 10.1038/ncb3509 (2017) [Overseas journal] *i)(21) Kudo K, Liu T, Murakami T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Wang Y, Ogasawara
K, Ogawa A, Sasaki M.: “Oxygen Extraction Fraction Measurement using Quantitative
Susceptibility Mapping: Comparison with Positron Emission Tomography”, JCBFM, 2016
Aug;36(8):1424-33 (2016) [Overseas journal](22) Cui Yi, Song J, Pollom E, Alagappan M, Shirato H, Chang DT, Koong AC, Li R: "Quantitative
analysis of 18F-fluorodeoxyglucose positron emission tomography identifies novel prognostic
imaging biomarkers in locally advanced pancreatic cancer patients treated with stereotactic bodyradiation therapy" Int J Radiat Onco Biol Phys, 2016 Sep 1;96(1):102-9.doi: 10.1016/j.ijrobp.
2016.04.034 (2016) [Overseas journal] *i) ○(23) Wu J, Cui Y, Sun X, Cao G, Li B, Ikeda DM, Kurian AW, Li R.: “Unsupervised clustering ofquantitative image phenotypes reveals breast cancer subtypes with distinct prognoses andmolecular pathways”, Clin Cancer Res. [Overseas journal] *i) ○(24) Cui Y, Tha KK, Terasaka S, Yamaguchi S, Wang J, Kudo K, Xing L, Shirato H, Li R: “Prognostic
imaging biomarkers in glioblastoma: development and independent validation on the basis ofmultiregion and quantitative analysis of MR images”, Radiology, 2016, 278(2): 546-53 (2016)[Overseas journal] *i) ○(25) Rankin EB, Nam JM, Giaccia AJ: “Hypoxia: Signaling the Metastatic Cascade”, Trends in Cancer,
2, 295–304, (2016) [Overseas journal] *i) ○(26) Bennink E, Oosterbroek J, Kudo K, Viergever MA, Velthuis BK, de Jong HW: “A Fast Non-Linear
Regression Method for CT Brain Perfusion Analysis”, J Med Imaging , 2016 Apr;3(2):026003. doi:
10.1117/1.JMI.3.2.026003. Epub 2016 Jun 16 (2016) [Overseas journal](27) Roseman DA, Hwang SJ, Oyama-Manabe N, Chuang ML, O'Donnell CJ, Manning WJ, Fox CS:“Clinical associations of total kidney volume: The framingham heart study”, NDT; - European
Renal Association (2016) [Overseas journal](28) Ohira H, Birnie DH, Pena E, Bernick J, Mc Ardle B, Leung E, Wells GA, Yoshinaga K, Tsujino
I, Sato T, Manabe O, Oyama-Manabe N, Nishimura M, Tamaki N, Dick A, Dennie C, Klein R,
Renaud J, deKemp RA, Ruddy TD, Chow BJ, Davies R, Hessian R, Liu P, Beanlands RS, Nery PB:“Comparison of (18)f-fluorodeoxyglucose positron emission tomography (fdg pet) and cardiac
magnetic resonance (cmr) in corticosteroid-naive patients with conduction system disease due tocardiac sarcoidosis”, E J of Nucl Med Mol Imaging. 2016;43:259-269 (2016) [Overseas journal](29) Cui Y, Tha KK, Terasaka S, Yamaguchi S, Wang J, Kudo K, Xing L, Shirato H, Li R: “Prognostic
Imaging Biomarkers in Glioblastoma: Development and Independent Validation on the Basis ofMultiregion and Quantitative Analysis of MR Images”, Radiology, 278(2):546-53, (2015) [Overseas
journal] *i) ii) ○(30) Le QT, Shirato H, Giaccia AJ, Koong AC: “Emerging Treatment Paradigms in Radiation69

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Oncology”, Clin Cancer Res., 1;21(15):3393-401, (2015) [Overseas journal] *i) ii) ○(31) Bazalova-Carter M, Ahmad M, Matsuura T, Takao S, Matsuo Y, Fahrig R, Shirato H, Umegaki
K, Xing L: “Proton-induced x-ray fluorescence CT imaging”, Med Phys., 2015 Feb;42(2):900-7(2015) [Overseas journal] *i) ○(32) Kudo K, Liu T, Murakami T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Wang Y, Ogasawara
K, Ogawa A, Sasaki M: “Oxygen Extraction Fraction Measurement using Quantitative
Susceptibility Mapping: Comparison with Positron Emission Tomography”, JCBFM, in press(2015) [Overseas journal](33) Kawakami H, Abo D, Kawakubo K, Kuwatani M, Yoshino Y, Kubota Y, Abe Y, Kawahata S, Kubo
K, Sakuhara Y, Shirato H, Sakamoto N: “Rendezvous biliary recanalization combining
percutaneous and endoscopic techniques using a diathermic dilator for bile duct obstruction”,
Endoscopy, 46 Suppl 1 UCTN:E460-1, (2014) [Overseas journal](34) Knopf A, Nill S, Yohannes I, Graeff C, Dowdell S, Kurz C, Sonke JJ, Biegun AK, Lang S,
McClelland J, Champion B, Fast M, Wolfelschneider J, Gianoli C, Rucinski A, Baroni G, RichterC, van de Water S, Grassberger C, Weber D, Poulsen P, Shimizu S, Bert C: “Challenges ofradiotherapy: report on the 4D treatment planning workshop 2013”, Phys Med., 30(7):809-15,(2014) [Overseas journal]2) Other original papers- major papers only.
Japanese journals (including those in English)(1) Kobashi K, Prayongrat A, Kimoto T, Toramatsu C, Dekura Y, Katoh N, Shimizu S, Ito YM,
Shirato H: “Assessing the uncertainty in a normal tissue complication probability difference (△NTCP): radiation-induced liver disease (RILD) in liver tumour patients treated with proton vs Xray therapy” J Radiat Res. Special Issue – Approaches to Select Advanced External Radiotherapy,
2018 Mar 1;59(suppl_1):i50-i57. doi: 10.1093/jrr/rry018. (2018) *i)(2) Nishioka K, Prayongrat A, Ono K, Onodera S, Hashimoto T, Katoh N, Inoue T, Kinoshita R,
Yasuda K, Mori T, Onimaru R, Shirato H, Shimizu S: “Prospective study to evaluate the safety of
the world-first spot-scanning dedicated, small 360-degree gantry, synchrotron-based proton beam
therapy system”, J Radiat Res. Volume 59, Issue suppl_1, March 2018, Pages i63-i71 2017 Dec 22.
doi: 10.1093/jrr/rrx083. [Epub ahead of print] PubMed PMID: 29309691 (2018) *i)(3) Takagi R, Komiya Y, Sutherland KL, Shirato H, Date H, Mizuta M: “Comparison of the averagesurviving fraction model with the integral biologically effective dose model for an optimal
irradiation scheme”, J Radiat Res. 2018 Jan 4. doi: 10.1093/jrr/rrx084. *i) (2018)(4) Manabe N: “New possibilities for use of delayed enhanced myocardium imaging in IQon Spectral
CT”, A Monthly Journal of Medical Imaging and Information, March (2018)(5) Abo D: “Methods using AVP in DP-CAR preoperative TAE”, Clinical Imageology, 34(2), February(2018)(6) Sakamoto K, Oyama-Manabe N, Manabe O, Aikawa T, Kikuchi Y, Sasai-Masuko H, Naya M,
Kudo K, Kato F, Tamaki N, Shirato H: “Heterogeneity of longitudinal and circumferential
contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patientswith preserved left ventricular ejection fraction”, Jpn Journal of Radiology. 2018 Feb;36(2):103112. doi: 10.1007/s11604-017-0700-5. Epub 2017 Nov 9. (2018)(7) Tha KK: “Practical application of radiogenomics by CT and MRI data in cancer” (1), Featuring
Step up MRI, Innervision, September, pp.41-43 (2017) *i)(8) Shimizu S, Nishioka K: “Urological tumor: bladder cancer”, Cancer and Radiotherapy, Revised
7th Edition (2017)(9) Ishikawa M: Chapter 4-2 “Radiation generators for medical use and related equipment”, Cancer

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and Radiotherapy, Revised 7th Edition (2017)(10) Yasuda K: “Radiotherapy using molecular imaging”, JSMI report. 10(2), May (2017)(11) Katoh N: “Stereotactic radiotherapy and proton beam therapy for liver cancers”, Jpn Journal of
Clinical Radiology, 62 (4), 521 – 528 (2017)(12) Katoh N: “Proton beam therapy for hepatocellular carcinomas”, Medical Science Digest, 43(7),324 – 327 (2017)(13) Umegaki K: “Image guided proton therapy system combining spot scanning and real-time tumor
tracking technologies”, BIO Clinica, 32(7), 666 – 671, July (2017)(14) Fujii Y, Matsuura T, Takao S, Matsuzaki Y, Fujii T, Miyamoto N, Umegaki K, Nishioka K,
Shimizu S, Shirato H: “A simulation study on the dosimetric benefit of real-time motion
compensation in spot-scanning proton therapy for prostate”, J Radiat Res. 2017 Jul 1;58(4):591597. doi: 10.1093/jrr/rrx020 (2017) *i)(15) Kadoya N, Karasawa K, Sumida I, Arimura H, Kakinohana Y, Kabuki S, Monzen H, Nishio T,
Shirato H, Yamada S:”Educational outcomes of a medical physicist program over the past 10 years
in Japan”, J Radiat Res. 2017 Apr 11:1-6. doi: 10.1093/jrr/rrx016. (2017)(16) Tamura M, Sakurai H, Mizumoto M, Kamizawa S, Murayama S, Yamashita H, Takao S, Suzuki
R, Shirato H, Ito YM: “Lifetime attributable risk of radiation-induced secondary cancer fromproton beam therapy compared with that of intensity-modulated X-ray therapy in randomly
sampled pediatric cancer patients”, J Radiat Res. 2017 May 1;58(3):363-371. doi:
10.1093/jrr/rrw088 (2017)(17) Ebina F, Umezawa M, Nishiuchi H, Aoki T, Hiramoto K, Matsuda K, Umegagi K, Furusaka M:“Development of a Compact Synchrotron for Proton Beam Therapy”, Electronics andCommunications in Japan. 2017 July. 100 (8) 34–42 doi: 10.1002/ecj.11972 (2017)(18) Shirato H, Nishioka K: “iGold - in vivo metallic fiducial markers in prostate cancer / liver cancer”,
Radiotherapy BOOK 2016, Rad Fan, November Extra edition (2016)(19) Shimizu S: “Intensity modulated proton beam therapy”, Ishiyaku Pub, Inc., Journal of Clinicaland Experimental Medicine, Igaku no ayumi, 257(1), pp. 19-24 (2016)(20) Shimizu S: “Advanced proton beam therapy - intensity modulated / real-time tumor tracking /cone beam CT –”, Life Medicom, Current Therapy, 34(5), pp. 58-63 (2016)(21) Shimizu S: “Comprehensive guide to heavy particle therapy / proton beam therapy at the Proton
beam irradiation facility and dedicated installations at Hokkaido University”, Kenkyu Kikaku
Publisher, pp. 104-105 (2016)(22) Sakuhara Y, Abo D, Soyama T, Morita R, Kudo K: “Puncture and drainage ―Basics andapplication of IVR”, Transdermal sclerotherapy for cystic lesions, Feature article, Rad Fan,
14(9):49-51 (2016)(23) Abo D, Sakuhara Y, Soyama T, Morita R, Kudo K, Tamoto E, Nakamura T, Hirano S: “Chapter
3, Alteration of blood flows during pancreatectomy ― focusing on techniques and procedures”,
Journal of biliary tract & pancreas (Kan to Sui), 37(5) (2016)(24) Manabe N: “Basics of cardiac MRI”, “Cardiomyopathy”, Koredakeha Shitteokitai Shinzo Kekkan

Shikkanno Gazosindan in Japanese (Basics of diagnostic imaging for cardiac and vasculardiseases), Gakken Medical Shujunsha Co.,Ltd. pp. 24-29, pp. 110-119 (2016)(25) Manabe N: “MRI of cardiac sarcoidosis”, Featuring sarcoidosis, January, Clinical Imageology(2016)(26) Manabe N: “Cardiac Perfusion of MRI and CT (in comparison)” Japan Association of RadiologicalTechnologists-magazine hosted 7th Heart CT (2016)(27) Harada T, Kudo K: “Present conditions and future of QSM”, A Monthly Journal of Medical
Imaging and Information, Sangyo Kaihatsukiko, Inc. (2016)(28) Mimura R, Kato F, Tha KK, Kudo K, Konno Y, Oyama-Manabe N, Kato T, Watari H, Sakuragi
N, Shirato H: “Comparison between borderline ovarian tumors and carcinomas using semi-

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automated histogram analysis of diffusion-ｗeighted imaging: focusing on solid components”, Jpn
J Radiol. 2016 Mar;34(3):229-37. doi: 10.1007/s11604-016-0518-6. Epub 2016 Jan 21. (2016)(29) Maeda K, Yasui H, Matsuura T, Yamamori T, Suzuki M, Nagane M, Nam JM, Inanami O, Shirato
H: “Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro”,
J Radiat Res. 2016 Jun;57(3):307-11. doi: 10.1093/jrr/rrv101. (2016) *i)(30) Maeda K, Yasui H, Matsuura T, Yamamori T, Suzuki M, Nagane M, Nam JM, Inanami O, Shirato
H: “Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro”,
J. Radiat. Res., 2016 Jun;57(3):307-11. doi: 10.1093/jrr/rrv101. Epub 2016 Feb 1. (2016) *i)(31) Umegaki K: “Development of an Innovative Proton Beam Therapy System”, Journal of IndustryAcademia-Government Collaboration, 1(12), 4-7, (2016)(32) Shirato H: “Progress of Radiation Therapy System (Feature article, The leading edge in Cancer
Radiation Therapy)”, The Journal of the Japan Medical Association, 144:233-236, (2015)(33) Oyama-Manabe N: “Myocardial perfusion imaging for evaluating viability with contrast
enhanced MRI”,Jpn Journal of Diagnostic Imaging (Rinsho-gazou), 31,159-166, (2015)(34) Oyama-Manabe N: “Left atrial myxoma, Adipoma, Metastatic cardiac tumor, Fibroma,
Malignant lymphoma, ‘CT/MRI for cardiovascular disease’”, Jpn Journal of Diagnostic Imaging,35, 944-953, (2015)(35) Oyama-Manabe N: “Heart CT/MRI update: Cardiac perfusion CT”, Jpn Journal of ClinicalRadiology, 60, 212-222, (2015)(36) Kudo K: “Basic theory of perfusion imaging”, NICHIDOKU-IHO, 60(2): 6-19, (2015)(37) Ishikawa M, Nagase N, Matsuura T, Hiratsuka J, Suzuki R, Miyamoto N, Sutherland KL, Fujita
K, Shirato H: “Development of a wavelength-separated type scintillator with optical fiber (SOF)dosimeter to compensate for the Cerenkov radiation effect”, J Radiat Res., 56(2):372-81. (2015)(38) Onimaru R, Hida K, Takeda N, Onodera S, Nishikawa Y, Mori T, Shirato H: “Threedimensional conformal fractionated radiotherapy for spinal schwannoma with a paravertebral oran intraosseous component”, Jpn J Radiol., 33(12):757-63, (2015)(39) Miyamoto N, Yabusaki S, Sakamoto K, Kikuchi Y, Mimura R, Kato F, Oyama-Manabe N,
Takahashi B, Soyama T, Abo D, Sakuhara Y, Kudo K, Shirato H, Nakamura T, Tsuchikawa T,
Okamura K, Hirano S: “Prediction of pancreatic anastomotic failure after pancreatic headresection using preoperative diffusion-weighted MR imaging”, Jpn J Radiol., 33: 59-66 (2015)(40) Miyamoto N, Ishikawa M, Sutherland K, Suzuki R, Matsuura T, Toramatsu C, Takao S, Nihongi
H, Shimizu S, Umegaki K, Shirato H: “A motion-compensated image filter for low-dose fluoroscopy
in a real-time tumor-tracking radiotherapy system”, J Rad Res., 56(1):186-196, (2015)(41) Kato F, Fujiwara T, Mimura R, Kudo K, Oyama-Manabe N, Sugimori H, Hosoda M, Yamashita
K, Shirato H: “Diffusion weighted imaging with slice selection gradient reversal method using 3tesla breast MRI”, Jpn Journal of Clinical Radiology, 59: 558-562, (2014)(42) Umegaki K: “Development of a Real-time Tumor-tracking Proton Beam Therapy System with
Molecular Imaging”, Electrical review, 99(6):30-34, (2014)(43) Shimizu S: “Next generation particle therapy: Integration of a real-time tumor monitoring
system into gated proton spot-scanning beam therapy”, New Medicine in Japan, 52-55, (2014)(44) Kudo K: “Diagnostic imaging guideline for central nerve system”, Jpn Journal of Diagnostic

Imaging(45) Kudo K: “MR perfusion imaging, Recent progress in stroke and cerebrovascular diseases”,
Nippon Rinsho, 72(5):538-543, (2014)(46) Nishio T, Shirato H, Ishikawa M, Miyabe Y, Kito S, Narita Y, Onimaru R, Ishikura S, Ito Y,
Hiraoka M: “Design, development of water tank-type lung phantom and dosimetric verification in
institutions participating in a phase I study of stereotactic body radiation therapy in patients with
T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial (JCOG0702)”. J Radiat
Res., 55(3):600-7, (2014)72

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(47) Matsumoto Y, Matsuura T, Wada M, Egashira Y, Nishio T, Furusawa Y: “Enhanced
radiobiological effects at the distal end of a clinical proton beam: in vitro study”, J Radiat Res.,
55(4):816-22 (2014)(48) Shimizu S, Tsuchiya K, Takao S, Shirato H: “Advanced radiation therapy project for cancer
treatment--from Hokkaido to the world, the world access to Hokkaido”, Hokkaido Igaku Zasshi,
89(1):25-8, (2014)
Overseas journals(1) Houkin K, Shichinohe H, Abe K, Arato T, Dezawa M, Honmou O, Horie N, Katayama Y, Kudo K,
Kuroda S, Matsuyama T, Miyai I, Nagata I, Niizuma K, Sakushima K, Sasaki M, Sato N,
Sawanobori K, Suda S, Taguchi A, Tominaga T, Yamamoto H, Yamashita T, Yoshimine T: on behalfof Working Group for Guidelines on Development of Cell-Based Products for the Treatment of
Cerebral Infarction, “Accelerating Cell Therapy for Stroke in Japan: Regulatory Framework andGuidelines on Development of Cell-Based Products”, Stroke 2018 In press (2018)(2) Miyata M, Kakeda S, Kudo K, Iwata S, Tanaka Y, Wang Y, Korogi Y: “Evaluation of oxygen
extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility
mapping”, JCBFM 2018 In press (2018)(3) Kudo K, Harada T, Kameda H, Uwano I, Yamashita F, Higuchi S, Yoshioka K, Sasaki M: “Indirect
Proton Magnetic Resonance Imaging and Kinetic Analysis of 17O-Labeled Water Tracer in the
Brain”, MRMS in press (2018)(4) Kwon J, Sutherland K, Hashimoto T, Shirato H, Date H: “Spatial distributions of doseenhancement around a gold nanoparticle at several depths of proton Bragg peak”, Nucl Instrum.
Methods Phys Res B. in press (2018)(5) Kameda H, Kudo K, Matsuda T, Harada T, Iwadate Y, Uwano I, Yamashita F, Yoshioka K, Sasaki
M, Shirato H: “Improvement of the Repeatability of Parallel Transmission at 7T Using Interleaved
Acquisition in the Calibration Scan”, Magn Reson Imaging, 2017 Dec 4. doi: 10.1002/jmri.25903[Epub ahead of print] (2018) *i)(6) Yoshida S, Shime H, Takeda Y, Nam JM, Takashima K, Matsumoto M, Shirato H, Kasahara M,
Seya T: “Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in amurine model”, Cancer Sci. 2018 Feb 21. doi: 10.1111/cas.13543. [Epub ahead of print] PubMed
PMID: 29465830. (2018) *i)(7) Shirato H: “Time has come for proton and carbon beam therapy”, Int J Clin Oncol.2018 Mar 8.
doi: 10.1007/s10147-018-1263-x. [Epub ahead of print] Review. PubMed PMID: 29520524 (2018)(8) Iwata H, Ishikawa H, Takagi M, Okimoto T, Murayama S, Akimoto T, Wada H, Arimura T, Sato
Y, Araya M, Mizoe JE, Gosho M, Nakamura K, Shirato H, Sakurai H: “Long-term outcomes ofproton therapy for prostate cancer in Japan: a multi-institutional survey of the JapaneseRadiation Oncology Study Group”, Cancer Med. 2018 Feb 14. doi: 10.1002/cam4.1350. [Epubahead of print] PubMed PMID: 29441697 (2018)(9) Kobayashi Y, Kamishima T, Sugimori H, Ichikawa S, Noguchi A, Kono M, Iiyama T, Sutherland
K, Atsumi T: “Quantification of Hand Synovitis in Rheumatoid Arthritis: Arterial Mask
Subtraction Reinforced With Mutual Information Can Improve Accuracy of Pixel-by-Pixel Time–
Intensity Curve Shape Analysis in Dynamic MRI”, J Magn Reson Imaging. Accepted for
publication Feb 13 (2018) *i)(10) Tang M, Oshinomi K, Ishizaka K, Tha KK, Yamamoto T: “Dependence of Scan Parameters on
Nerve Fiber Crossing Depiction in Diffusion Spectrum Imaging in Clinical Practice”, J Comput
Assist Tomogr. 2018 Jan 24. doi: 10.1097/RCT.0000000000000715 (2018) *i)(11) Ueda H, Furusaka M, Matsuura T, Hirayama S, Umegaki K: “Theoretical analysis of angular
distribution of scattering in nozzle components using a response-function method for proton spotscanning therapy”, Phys Med Biol. 2018 Jan 22. (63). doi: 10.1088/1361-6560/aaa15a (2018)73

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(12) Katoh N, Soda I, Tamamura H, Takahashi S, Uchinami Y, Ishiyama H, Ota K, Inoue T, Onimaru
R, Shibuya K, Hayakawa K, Shirato H: “Clinical outcomes of stage I and IIA non-small cell lungcancer patients treated with stereotactic body radiotherapy using a real-time tumor-tracking
radiotherapy system”, Radiat Oncol. 2017 Jan 5;12(1):3. doi: 10.1186/s13014-016-0742-3. (2017)*i)(13) Fujima N, Yoshida D, Sakashita T, Homma A, Kudo K, Shirato H: “Residual tumour detection in
post-treatment granulation tissue by using advanced diffusion models in head and neck squamouscell carcinoma patients”, Eur J Radiol. 2017 May;90:14-19. doi: 10.1016/j.ejrad.2017.02.025 (2017)*i)(14) Ishizaka K, Kudo K, Harada K, Shirai T, Fujiwara T, Aoike S, Takamori S, Shirato H: “Simple
modification of arm position improves B1+ and signal homogeneity in the thoracolumbar spine at3T”, J Magn Reson Imaging. 2017 May 26. doi: 10.1002/jmri.25767. [Epub ahead of print] (2017)(15) Fujima N, Sakashita T, Homma A, Yoshida D, Kudo K, Shirato H: “Utility of a Hybrid IVIM-DKI
Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell
Carcinoma Patients”, Magn Reson Med Sci. 2017 May 18. doi: 10.2463/mrms.mp.2016-0136 (2017)*i)(16) Fujima N, Sakashita T, Homma A, Harada T, Shimizu Y, Tha KK, Kudo K, Shirato H: “Noninvasive prediction of the tumor growth rate using advanced diffusion models in head and necksquamous cell carcinoma patients”, Oncotarget. 2017 May 16;8(20):33631-33643. doi:
10.18632/oncotarget.16851 (2017) *i)(17) Yabusaki S, Oyama-Manabe N, Manabe O, Hirata K, Kato F, Miyamoto N, Matsuno Y, Kudo K,
Tamaki N, Shirato H: “Characteristics of immunoglobulin G4-related aortitis/periaortitis andperiarteritis on fluorodeoxyglucose positron emission tomography/computed tomography coregistered with contrast-enhanced computed tomography”, EJNMMI Res. 2017 Dec;7(1):20. doi:
10.1186/s13550-017-0268-1. Epub 2017 Feb 27 (2017)(18) Kudo K, Harada T, Kameda H, Uwano I, Yamashita F, Higuchi S, Yoshioka K, Sasaki M: “Indirect
MRI of 17 o-labeled water using steady-state sequences: Signal simulation and preclinicalexperiment”, J Magn Reson Imaging. 2017 Aug 31. doi: 10.1002/jmri.25848. [Epub ahead of print](2017)(19) Soyama T, Yoshida D, Sakuhara Y, Morita R, Abo D, Kudo K: “The Steerable Microcatheter: A
New Device for Selective Catheterisation”, Cardiovasc Intervent Radiol. 2017 Jun;40(6):947-952.
doi: 10.1007/s00270-017-1579-3 (2017)(20) Kudo K, Uwano I, Hirai T, Murakami R, Nakamura H, Fujima N, Yamashita F, Goodwin J,
Higuchi S, Sasaki M: “Comparison of Different Post-Processing Algorithms for Dynamic
Susceptibility Contrast Perfusion Imaging of Cerebral Gliomas”, Magn Reson Med Sci. 2017 Apr
10;16(2):129-36 (2017)(21) Hatano K, Kamishima T, Sutherland K, Kato M, Nakagawa I, Ichikawa S, Kawauchi K, Saitou
S, Mukai M: “A reliability study using computer-based analysis of finger joint space narrowing inrheumatoid arthritis patients”, Rheumatol Int. 2017 Feb;37(2):189-195. doi: 10.1007/s00296-0163588-y. (2017)(22) Sakano R, Saito K, Kamishima T, Nishida M, Horie T, Noguchi A, Kono M, Sutherland K, Atsumi
T: “Power Doppler signal calibration in the finger joint between two models of ultrasound machine:a pilot study using a phantom and joints in patients with rheumatoid arthritis”, Acta Radiol. 2017
Jan 1:284185116685923. doi: 10.1177/0284185116685923 (2017)(23) Ichikawa S, Kamishima T, Sutherland K, Kasahara H, Shimizu Y, Fujimori M, Yasojima N, Ono
Y, Kaneda T, Koike T: “Semi-Automated Quantification of Finger Joint Space Narrowing Using
Tomosynthesis in Patients with Rheumatoid Arthritis”, J Digit Imaging. 2017 Jun;30(3):369-375.
doi: 10.1007/s10278-017-9949-6 (2017)(24) Wada Y, Kamishima T, Shimamura T, Kawamura N, Yamashita K, Sutherland K, Takeda H:“Pre-operative volume rather than area of skeletal muscle is a better predictor for post-operative74

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risks for respiratory complications in living-donor liver transplantation”, Br J Radiol. 2017
Apr;90(1072):20160938. doi: 10.1259/bjr.20160938 (2017)(25) Ichikawa S, Kamishima T, Sutherland K, Fukae J, Katayama K, Aoki Y, Okubo T, Okino T,
Kaneda T, Takagi S, Tanimura K: “Computer-Based Radiographic Quantification of Joint Space
Narrowing Progression Using Sequential Hand Radiographs: Validation Study in Rheumatoid
Arthritis Patients from Multiple Institutions”, J Digit Imaging. 2017 Apr 4. doi: 10.1007/s10278017-9970-9 (2017)(26) Nomura Y, Kamishima T, Sutherland K, Nishimura H: “Visceral adipose tissue area
measurement at a single level: can it represent visceral adipose tissue volume? “(accepted by BJR)
(27) Fujimori M, Nakamura S, Hasegawa K, Ikeno K, Ichikawa S, Sutherland K, Kamishima T:“Cartilage quantification using contrast-enhanced MRI in the wrist of rheumatoid arthritis:
cartilage loss is associated with bone marrow edema”, Br J Radiol. 2017 Aug;90(1077):20170167.
doi: 10.1259/bjr.20170167 (2017)(28) Nishioka K, Shimizu S, Shinohara N, Ito YM, Abe T, Maruyama S, Katoh N, Kinoshita R,
Hashimoto T, Miyamoto N, Onimaru R, Shirato H: “Analysis of inter-and intra fractional partial
bladder wall movement using implanted fiducial markers”, Radiat Oncol. 2017 Mar 1;12(1):44.
doi: 10.1186/s13014-017-0778-z.PubMed PMID: 28249609; PubMed Central PMCID:
PMC5333467 (2017) *i)(29) Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H,
Fuji H, Okumura T, Shirato H, Sakurai H: “Long-term follow-up after proton beam therapy forpediatric tumors: a Japanese national survey”, Cancer Sci. 2017 Mar;108(3):444-447. doi:
10.1111/cas.13140. PubMed PMID: 28004469; PubMed Central PMCID: PMC5378281 (2017)(30) Uwano I, Kudo K, Sato R, Ogasawara K, Kameda H, Nomura JI, Mori F, Yamashita F, Ito K,
Yoshioka K, Sasaki M: “Noninvasive Assessment of Oxygen Extraction Fraction in Chronic
Ischemia Using Quantitative Susceptibility Mapping at 7 Tesla”, Stroke, 2017 Aug;48(8):21362141. doi: 10.1161/STROKEAHA.117.017166 (2017)(31) Aikawa T, Oyama-Manabe N, Naya M, Ohira H, Sugimoto A, Tsujino I, Obara M, Manabe O,
Kudo K, Tsutsui H, Tamaki N: “Delayed contrast-enhanced computed tomography in patients withknown or suspected cardiac sarcoidosis: A feasibility study”, Eur Radiol. 2017 Apr 5. doi:
10.1007/s00330-017-4824-x. [Epub ahead of print] (2017)(32) Aikawa T, Naya M, Obara M, Oyama-Manabe N, Manabe O, Magota K, Ito YM, Katoh C, Tamaki
N: “Regional interaction between myocardial sympathetic denervation, contractile dysfunction,and fibrosis in heart failure with preserved ejection fraction: 11C-hydroxyephedrine PET study”,
Eur J Nucl Med Mol Imaging. 2017 Jun 26. doi: 10.1007/s00259-017-3760-y. (2017)(33) Manabe O, Naya M, Aikawa T, Obara M, Magota K, Kroenke M, Oyama-Manabe N, Hirata K,
Shinyama D, Katoh C, Tamaki N: “PET/CT scanning with 3D acquisition is feasible forquantifying myocardial blood flow when diagnosing coronary artery disease”, EJNMMI Res. 2017
Dec;7(1):52. doi: 10.1186/s13550-017-0296-x (2017)(34) Kazumata K, Tha KK, Uchino H, Ito M, Nakayama N, Abumiya T: “Mapping altered brain
connectivity and its clinical associations in adult moyamoya disease: A resting-state functional
MRI study”, PLoS One. 2017 Aug 4;12(8):e0182759. doi: 10.1371/journal.pone.0182759 (2017)(35) Kazumata K, Tha KK, Uchino H, Shiga T, Shichinohe H, Ito M, Nakayama N, Abumiya T:“Topographic changes in cerebral blood flow and reduced white matter integrity in the first 2
weeks following revascularization surgery in adult moyamoya disease”, J Neurosurg. 2017
Aug;127(2):260-269. doi: 10.3171/2016.6.JNS16653 (2017)(36) Sakamoto S, Goto R, Kawamura N, Koshizuka Y, Watanabe M, Ota M, Suzuki T, Abo D,
Yamashita K, Kamiyama T, Taketomi A, Shimamura T: “Petersen's hernia after living donor livertransplantation”, Surg Case Rep. 2017 Aug 23;3(1):89. doi: 10.1186/s40792-017-0364-5 (2017)(37) Ebina F, Umezawa M, Nishiuchi H, Aoki T, Hiramoto K, Matsuda K, Umegagi K, Furusaka M:

A75

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“Development of a Compact Synchrotron for Proton Beam Therapy”, Electronics andCommunications in Japan. 2017 July. 100 (8) 34–42 doi: 10.1002/ecj.11972 (2017)(38) Nomura J, Uwano I, Sasaki M, Kudo K, Yamashita F, Ito K, Fujiwara S, Kobayashi M,
Ogasawara K: “Preoperative Cerebral Oxygen Extraction Fraction Imaging Generated from 7Tesla Magnetic Resonance Quantitative Susceptibility Mapping Predicts Development of Cerebral
Hyperperfusion Following Carotid Endarterectomy”, AJNR Am J Neuroradiol. 2017 Oct 5. doi:
10.3174/ajnr.A5390 (2017)(39) Hashimoto N, Ito YM, Okada N, Yamamori H, Yasuda Y, Fujimoto M, Kudo N, Takemura A, Son
S, Narita H, Yamamoto M, Tha KK, Katsuki A, Ohi K, Yamashita F, Koike S, Takahashi T, Nemoto
K, Fukunaga M, Onitsuka T, Watanabe Y, Yamasue H, Suzuki M, Kasai K, Kusumi I, Hashimoto
R: “The effect of duration of illness and antipsychotics on subcortical volumes in schizophrenia:
Analysis of 778 subjects”, Neuroimage Clin. 2017 Nov 8;17:563-569 (2017)(40) Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Shimizu Y, Tha KK, Kudo K,
Shirato H: “Prediction of the treatment outcome using intravoxel incoherent motion anddiffusional kurtosis imaging in nasal or sinonasal squamous cell carcinoma patients”, Eur Radiol.
2017 Mar;27(3):956-96 (2017) *i)(41) Harada K, Katoh N, Suzuki R, Ito YM, Shimizu S, Onimaru R, Inoue T, Miyamoto N, Shirato
H: “Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT)with four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy
system (RTRT)”, Phys Med. 2016 Feb;32(2):305-11. doi: 10.1016/j.ejmp.2015.10.093. (2016) *i)(42) Yoshimura T, Kinoshita R, Onodera S, Toramatsu C, Suzuki R, Ito YM, Takao S, Matsuura T,
Matsuzaki Y, Umegaki K, Shirato H, Shimizu S: “NTCP modeling analysis of acute hematologic
toxicity in whole pelvic radiation therapy for gynecologic malignancies - A dosimetric comparisonof IMRT and spot-scanning proton therapy (SSPT)”, Phys Med. 2016 Sep;32(9):1095-102. doi:
10.1016/j.ejmp.2016.08.007. (2016) *i)(43) Uchinami Y, Myojin M, Takahashi H, Harada K, Shimizu S, Hosokawa M: “Prognostic factors inclinical T1N0M0 thoracic esophageal squamous cell carcinoma invading the muscularis mucosa
or submucosa”, Radiat Oncol., 2016 Jun 21;11:84. doi: 10.1186/s13014-016-0660-4. (2016)(44) Onimaru R, Onishi H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M,
Shioyama Y, Matsushita H, Ito Y, Shirato H: “Phase I study of stereotactic body radiation therapy
for peripheral T2N0M0 non-small cell lung cancer (JCOG0702): Results for the group with PTV≧100 cc”, Radiother Oncol. 2016 in press. doi: 10.1016/j.radonc.2016.11.022 (2016)(45) Soyama T, Sakuhara Y, Kudo K, Abo D, Wang J, Ito YM, Hasegawa Y, Shirato H: “Comparisonof conventional ultrasonography and ultrasonography-computed tomography fusion imaging fortarget identification using digital/real hybrid phantoms: a preliminary study”, J Med Ultrason(2001). 2016 Jul;43(3):327-35. doi: 10.1007/s10396-016-0704-2 (2016)(46) Fujima N, Osanai T, Shimizu Y, Yoshida A, Harada T, Nakayama N, Kudo K, Houkin K, Shirato
H: “Utility of noncontrast-enhanced time-resolved four-dimensional MR angiography with avessel-selective technique for intracranial arteriovenous malformations”, J Magn Reson Imaging.
2016 Oct;44(4):834-45. doi: 10.1002/jmri.25222. (2016) *i)(47) Harada T, Kudo K, Uwano I, Yamashita F, Kameda H, Matsuda T, Sasaki M, Shirato H: “Breathholding during the Calibration Scan Improves the Reproducibility of Parallel Transmission at 7T
for Human Brain”, Magn Reson Med Sci. 2016 Mar 21 (2016)(48) Hamaguchi H, Tha KK, Sugimori H, Nakanishi M, Nakagawa S, Fujiwara T, Yoshida H,
Takamori S, Shirato H. “Effect of respiratory and cardiac gating on the major diffusion-imaging
metrics” Neuroradiol J. 2016 Aug;29(4):254-9. doi: 10.1177/1971400916643337. (2016) *i)(49) Fujima N, Sakashita T, Homma A, Hirata K, Shiga T, Kudo K, Shirato H: “Glucose Metabolism
and Its Complicated Relationship with Tumor Growth and Perfusion in Head and Neck Squamous
Cell Carcinoma”, PLoS One. 2016 Nov 8;11(11): e0166236. doi: 10.1371/journal.pone.0166236.

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(2016) *i)(50) Fujima N, Sakashita T, Homma A, Shimizu Y, Yoshida A, Harada T, Tha KK, Kudo K, Shirato
H: “Advanced diffusion models in head and neck squamous cell carcinoma patients: Goodness offit, relationships among diffusion parameters and comparison with dynamic contrast-enhanced
perfusion”, Published online: October 27, 2016 (2016) *i)(51) Sakashita T, Kamishima T, Sugimori H, Tang M, Noguchi A, Kono M, Sutherland K, Tatsuya A:“Pixel-by-Pixel Arterial Spin Labeling Blood Flow Pattern Variation Analysis for Discriminationof Rheumatoid Synovitis: A Pilot Study”, Magn Reson Med Sci. 05/2016;
doi:10.2463/mrms.tn.2015-0145 (2016)(52) Ono Y, Kashihara R, Yasojima N, Kasahara H, Simizu Y, Tamura K, Tsutsumi K, Sutherland K,
Koike T, Kamishima T: “Tomosynthesis can Facilitate Accurate Measurement of Joint Space
Width under the Condition of the Oblique Incidence of X-rays in Rheumatoid Arthritis Patients”,
Br J Radiol. 06/2016; 89(1062):20150967. doi: 10.1259/bjr.20150967 (2016)(53) Sakasita T, Kamishima T, Kobayashi Y, Sugimori H, Tang M, Sutherland K, Noguchi A, Kono M,
Atsumi T: “Accurate Quantitative Assessment of Synovitis in Rheumatoid Arthritis Using Pixelby-Pixel, Time-Intensity Curve Shape Analysis” Br J Radiol. 03/2016; 89(1061):20151000. doi:
10.1259/bjr.20151000 (2016)(54) Yamada T, Miyamoto N, Matsuura T, Takao S, Fujii Y, Matsuzaki Y, Koyano H, Umezawa M,
Nihongi H, Shimizu S, Shirato H, Umegaki K: “Optimization and evaluation of multiple gating
beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging
technique”, Phys Med. 2016 Jul;32(7):932-7. doi: 10.1016/j.ejmp.2016.06.002. (2016) *i) ii)(55) Kanehira T, Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Ito YM, Miyamoto N, Inoue T,
Katoh N, Shimizu S, Umegaki K, Shirato H: “Impact of Real-Time Image Gating on Spot Scanning
Proton Therapy for Lung Tumors: A Simulation Study”, Int J Radiat Oncol Biol Phys. 2016 Sep
28. pii: S0360-3016(16)33238-2. doi: 10.1016/j.ijrobp.2016.09.027. (2016) *i)(56) Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato
H: “A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo- Pentofuranosyl) Cytosine, Induces
Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton
Beam”, PLoS One. 2016 Nov 22;11(11):e0166848. doi: 10.1371/journal.pone.0166848. (2016)(57) Onimaru R, Onishi H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M,
Shioyama Y, Matsushita H, Ito Y, Shirato H: “Phase I study of stereotactic body radiation therapy
for peripheral T2N0M0 non-small cell lung cancer (JCOG0702): Results for the group with
PTV⩾100cc”, Radiother Oncol. 2017 Feb;122(2):281-285. doi: 10.1016/j.radonc.2016.11.022. Epub
2016 Dec 16. PubMed PMID: 27993416. (2016)(58) Matsuura T, Fujii Y, Takao S, Yamada T, Matsuzaki Y, Miyamoto N, Takayanagi T, Fujitaka S,
Shimizu S, Shirato H, Umegaki K: “Development and evaluation of a short-range applicator fortreating superficial moving tumors with respiratory-gated spot-scanning proton therapy using
real-time image guidance”, Phys Med Biol. 2016 Feb 21;61(4):1515-31. doi: 10.1088/00319155/61/4/1515. Epub 2016 Jan 27. PubMed PMID: 26815927. (2016) *i)(59) Suzuki T, Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Yoshida D, Fujima N,
Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S: “Effectiveness of superselective
intra-arterial chemoradiotherapy targeting retropharyngeal lymph node metastasis”, Eur Arch
Otorhinolaryngol. 2016 Oct;273(10):3331-6. doi: 10.1007/s00405-016-3933-5. (2016)(60) Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H,
Fuji H, Okumura T, Shirato H, Sakurai H: “Proton beam therapy for pediatric malignancies: aretrospective observational multicenter study in Japan”, Cancer Med. 2016 Jul;5(7):1519-25. doi:
10.1002/cam4.743. (2016)(61) Okamoto S, Shiga T, Yasuda K, Watanabe S, Hirata K, Nishijima KI, Magota K, Kasai K,
Onimaru R, Tuchiya K, Kuge Y, Shirato H, Tamaki N: “The reoxygenation of hypoxia and the77

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reduction of glucose metabolism in head and neck cancer by fractionated radiotherapy withintensity-modulated radiation therapy”, Eur J Nucl Med Mol Imaging. 2016 Nov;43(12):2147-2154.
(2016)(62) Hamada T, Sutherland K, Ishikawa M, Miyamoto N, Honma S, Shirato H, Honma K: “In vivo
imaging of clock gene expression in multiple tissues of freely moving mice”, Nat Commun. 2016
Jun 10;7:11705. doi: 10.1038/ncomms11705. (2016) *i)(63) Narita H, Tha KK, Hashimoto N, Hamaguchi H, Nakagawa S, Shirato H, Kusumi I: “Meankurtosis alterations of cerebral white matter in patients with schizophrenia revealed by diffusion
kurtosis imaging”, Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:169-75. doi:
10.1016/j.pnpbp.2016.07.011. (2016) *i)(64) Niibe Y, Nishimura T, Inoue T, Karasawa K, Shioyama Y, Jingu K, Shirato H: “Oligo-recurrence
predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lungcancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional
study of 61 subjects”, BMC Cancer, 2016 Aug 19;16(1):659. doi: 10.1186/s12885-016-2680-8. (2016)(65) Homma A, Hatakeyama H, Mizumachi T, Kano S, Sakashita T, Kuramoto R, Nakamaru Y,
Onimaru R, Tsuchiya K, Yoshida D, Yasuda K, Shirato H, Fukuda S: “ A Retrospective Study of GTube Use in Japanese Patients Treated with Concurrent Chemoradiotherapy for Hypopharyngeal
Cancer”, PLoS One. 2016 Aug 24;11(8):e0161734. doi: 10.1371/journal.pone.0161734. (2016)(66) Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y,
Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H: “P53- and mevalonate pathway-driven
malignancies require Arf6 for metastasis and drug resistance”, J Cell Biol. 2016 Apr 11;213(1):8195. doi: 10.1083/jcb.201510002. (2016) *i)(67) Komiya Y, Onodera Y, Kuroiwa M, Nomimura S, Kubo Y, Nam JM, Kajiwara K, Nada S,
Oneyama C, Sabe H, Okada M: “The Rho guanine nucleotide exchange factor ARHGEF5 promotes
tumor malignancy via epithelial-mesenchymal transition”, Oncogenesis, 2016 Sep 12;5(9):e258.
doi: 10.1038/oncsis.2016.59. (2016) *i)(68) Otsuka Y, Sato H, Oikawa T, Onodera Y, Nam JM, Fukunaga K, Hatanaka KC, Hatanaka Y,
Matsuno Y, Fukuda S, Sabe H: “High expression of EPB41L5, an integral component of the Arf6driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the
tongue”, Cell Commun Signal, 2016, 14:28. DOI: 10.1186/s12964-016-0151-0 (2016) *i)(69) Kazumata K, Tha KK, Narita H, Shichinohe H, Ito M, Uchino H, Abumiya T: “Investigating
Brain Network Characteristics Interrupted by Covert White Matter Injury in Patients with
Moyamoya Disease: Insights from Graph Theoretical Analysis”, World Neurosurg. 2016
May;89:654-665.e2. (2016)(70) Tan C, Shichinohe H, Wang Z, Hamauchi S, Abumiya T, Nakayama N, Kazumata K, Ito T, Kudo
K, Takamoto S, Houkin K: “Feasibility and efficiency of human bone marrow stromal cell culture
with allogeneic platelet lysate-supplementation for cell therapy against stroke”, Stem Cells Int.
2016;2016:6104780. Epub 2016 Oct 20. (2016)(71) Kazumata K, Tha KK, Narita H, Ito YM, Shichinohe H, Ito M, Uchino H, Abumiya T:“Characteristics of Diffusional Kurtosis in Chronic Ischemia of Adult Moyamoya Disease:
Comparing Diffusional Kurtosis and Diffusion Tensor Imaging”, AJNR Am J Neuroradiol. 2016
Aug;37(8):1432-9. doi: 10.3174/ajnr.A4728. (2016)(72) Watanabe S, Manabe O, Hirata K, Oyama-Manabe N, Hattori N, Kikuchi Y, Kobayashi K,
Toyonaga T, Tamaki N: “The usefulness of (18)f-fdg pet/ct for assessing methotrexate-associatedlymphoproliferative disorder (mtx-lpd)”, BMC cancer, 2016;16:635 (2016)(73) Sugaya T, Oyama-Manabe N, Yamaguchi T, Tamaki N, Ishimaru S, Okabayashi H, Furuya J,
Yoshida T, Igarashi Y, Igarashi K: “Visualization of collateral channels with coronary computed
tomography angiography for the retrograde approach in percutaneous coronary intervention forchronic total occlusion”, Journal of cardiovascular computed tomography, 2016;10:128-134 (2016)78

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(74) Noguchi A, Kato M, Kono M, Ohmura K, Ohira H, Tsujino I, Oyama-Manabe N, Oku K, Bohgaki
T, Horita T, Yasuda S, Nishimura M, Atsumi T: “Bi-ventricular interplay in patients with systemicsclerosis-associated pulmonary arterial hypertension: Detection by cardiac magnetic resonance”,
Modern rheumatology, 2016:1-8 (2016)(75) Manabe O, Yoshinaga K, Ohira H, Masuda A, Sato T, Tsujino I, Yamada A, Oyama-Manabe N,
Hirata K, Nishimura M, Tamaki N: “The effects of 18-h fasting with low-carbohydrate dietpreparation on suppressed physiological myocardial (18)f-fluorodeoxyglucose (fdg) uptake andpossible minimal effects of unfractionated heparin use in patients with suspected cardiac
involvement sarcoidosis”, J Nucl Cardiol. 2016;23:244-252 (2016)(76) Manabe O, Oyama-Manabe N, Naya M, Aikawa T, Sakakibara M, Tsutsui H, Tamaki N: “ Pitfallsof 18f-fdg pet for evaluating myocardial viability”, J Nucl Cardiol.: official publication of theAmerican Society of Nuclear Cardiology , 2016 (2016)(77) Manabe O, Hirata K, Shozo O, Shiga T, Uchiyama Y, Kobayashi K, Watanabe S, Toyonaga T,
Kikuchi H, Oyama-Manabe N, Tamaki N: “18f-fluoromisonidazole (fmiso) pet may have thepotential to detect cardiac sarcoidosis”, J Nucl Cardiol. 2016 (2016)(78) Aikawa T, Naya M, Oyama-Manabe N, Maekawa S, Nambu H, Mitsuyama H, Hirata K, KannoOkada H, Tsutsui H: “18f-fdg pet findings of pericardial lymphangiohemangioma”, J Nucl cardiol.:official publication of the American Society of Nuclear Cardiology, 2016 (2016)(79) Kubo K, Kawakami H, Kuwatani M, Nishida M, Kawakubo K, Kawahata S, Taya Y, Kubota Y,
Amano T, Shirato H, Sakamoto N: “Liver elasticity measurement before and after biliary drainage
in patients with obstructive jaundice: a prospective cohort studya prospective cohort study”, BMC
Gastroenterol. 2016 Jul 8;16(1):65. doi: 10.1186/s12876-016-0479-3. (2016)(80) Uwano I, Sasaki M, Kudo K, Boutelier T, Kameda H, Mori F, Yamashita F: “Tmax Determined
Using a Bayesian Estimation Deconvolution Algorithm Applied to Bolus Tracking Perfusion
Imaging: A Digital Phantom Validation Study”, Magn Reson Med Sci. 2017 Jan 10;16(1):32-7.
(2016)(81) Matsuura T, Fujii Y, Takao S, Yamada T, Matsuzaki Y, Miyamoto N, Takayanagi T, Fujitaka S,
Shimizu S, Shirato H: “Development and evaluation of a short-range applicator for treatingsuperficial moving tumors with respiratory-gated spot-scanning proton therapy using real-time
image guidance”, Phys Med Biol., 61(4):1515-31 (2016) *i)(82) Takao S, Miyamoto N, Matsuura T, Onimaru R, Katoh N, Inoue T, Sutherland KL, Suzuki R,
Shirato H, Shimizu S: “Intrafractional Baseline Shift or Drift of Lung Tumor Motion During Gated
Radiation Therapy With a Real-Time Tumor-Tracking System”, Int J Radiat Oncol Biol Phys,
94(1):172-80 (2016) *i)(83) Harada K, Katoh N, Suzuki R, Ito YM, Shimizu S, Onimaru R, Inoue T, Miyamoto N, Shirato H.
“Evaluation of the motion of lung tumors during stereotactic body radiation therapy (SBRT) with
four-dimensional computed tomography (4DCT) using real-time tumor-tracking radiotherapy
system (RTRT)”, Phys Med., 32(2):305-11. (2016) *i)(84) Fujima N, Osanai T, Shimizu Y, Yoshida A, Harada T, Nakayama N, Kudo K, Houkin K, Shirato
H: “Utility of noncontrast-enhanced time-resolved four-dimensional MR angiography with avessel-selective technique for intracranial arteriovenous malformations” , J Magn Reson Imaging,in press (2016) *i)(85) Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Tha KK, Kudo K, Shirato H:“Usefulness of Pseudocontinuous Arterial Spin-Labeling for the Assessment of Patients with Headand Neck Squamous Cell Carcinoma by Measuring Tumor Blood Flow in the Pretreatment and
Early Treatment Period”, AJNR Am J Neuroradiol., Feb;37(2):342-8, (2016) *i)(86) Kato F, Kudo K, Yamashita H, Wang J, Hosoda M, Hatanaka KC, Mimura R, Oyama-Manabe N,
Shirato H: “Differences in morphological features and minimum apparent diffusion coefficientvalues among breast cancer subtypes using 3-tesla MRI”, Eur J Radiol., 85(1):96-102. (2016).

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(87) Hashimoto A, Oikawa T, Hashimoto S, Sugino H, Yoshikawa A, Otsuka Y, Handa H, Onodera Y,
Nam JM, Oneyama C, Okada M, Fukuda M, Sabe H.： “P53- and mevalonate pathway-driven
malignancies require Arf6 for metastasis and drug resistance”, J Cell Biol., 2016 Apr 11;213(1):8195. doi: 10.1083/jcb.201510002. Epub 2016 Apr 4. (2016) *i)(88) Shirato H: “Radiotherapy: characteristics of particle therapy and its perspective”, Annals of
Oncology, 2015 Nov EL19;26:65-65 (2015)(89) Wang J, Kato F, Oyama-Manabe N, Li R, Cui Y, Tha KK, Yamashita H, Kudo K, Shirato H:“Identifying Triple-Negative Breast Cancer Using Background Parenchymal Enhancement
Heterogeneity on Dynamic Contrast-Enhanced MRI: A Pilot Radiomics Study”, PLoS One.,10(11):e0143308. (2015) *i)(90) Sugano Y, Mizuta M, Takao S, Shirato H, Sutherland KL, Date H: “Optimization of thefractionated irradiation scheme considering physical doses to tumor and organ at risk based on
dose-volume histograms”, Med Phys., 42;11:6203-6210 (2015)(91) Harada Y, Hirata K, Nakayama N, Yamaguchi S, Yoshida M, Onodera S, Manabe O, Shiga T,
Terae S, Shirato H, Tamaki N: “Improvement of cerebral hypometabolism after resection ofradiation-induced necrotic lesion in a patient with cerebral arteriovenous malformation”, Acta
Radiol Open., 27;4(6):2058460115584112, (2015)(92) Fujima N, Kameda H, Tsukahara A, Yoshida D, Sakashita T, Homma A, Tha KK, Kudo K,
Shirato H: “Diagnostic value of tumor blood flow and its histogram analysis obtained with pCASL
to differentiate sinonasal malignant lymphoma from squamous cell carcinoma”, Eur J Radiol.,84(11):2187-93, (2015) *i)(93) Onimaru R, Shirato H, Shibata T, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M,
Shioyama Y, Matsushita H, Ito Y, Onishi H: “Phase I study of stereotactic body radiation therapy
for peripheral T2N0M0 non-small cell lung cancer with PTV<100cc using a continual
reassessment method (JCOG0702)”, Radiother Oncol., 116(2):276-80, (2015)(94) Aoyama H, Tago M, Shirato H: Japanese Radiation Oncology Study Group 99-1 (JROSG 99-1)
Investigators: “Stereotactic Radiosurgery With or Without Whole-Brain Radiotherapy for Brain
Metastases: Secondary Analysis of the JROSG 99-1 Randomized Clinical Trial”, JAMA Oncol,
1(4):457-64, (2015)(95) Kunimatsu J, Miyamoto N, Ishikawa M, Shirato H, Tanaka M: “Application of radiosurgical
techniques to produce a primate model of brain lesions”, Front Syst Neurosci, 24;9:67. (2015)(96) Furusawa J, Homma A, Onimaru R, Sakashita T, Yoshida D, Hatakeyama H, Mizumachi T, Kano
S, Tsuchiya K, Yasuda K, Shirato H, Fukuda S: “Indications for superselective intra-arterial
cisplatin infusion and concomitant radiotherapy in cases of hypopharyngeal cancer”, Auris Nasus
Larynx, 42(6):443-8, (2015)(97) Homma A, Nakamaru Y, Sakashita T, Onimaru R, Terasaka S, Tsuchiya K, Yoshida D, Yasuda
K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Shirato H, Fukuda S: “Management forsquamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience”,
Auris Nasus Larynx, 42(5):377-81 (2015)(98) Sakuhara Y, Nishio S, Morita K, Abo D, Hasegawa Y, Yuasa N, Mochizuki T, Soyama T, Oba K,
Shirato H, Kudo K: “Transcatheter Arterial Embolization with Ethanol Injection in SymptomaticPatients with Enlarged Polycystic Kidneys”, Radiology, 277(1):277-85, (2015)(99) Mori T, Onimaru R, Onodera S, Tsuchiya K, Yasuda K, Hatakeyama H, Kobayashi H, Terasaka
S, Homma A, Shirato H: “Olfactory neuroblastoma: the long-term outcome and late toxicity ofmultimodal therapy including radiotherapy based on treatment planning using computed
tomography”, Radiat Oncol., 15;10(1):88. (2015)(100) Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru
R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S: “Comparison of acute toxicities associated withcetuximab-based bioradiotherapy and platinum-based chemoradiotherapy for head and neck80

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squamous cell carcinomas: A single-institution retrospective study in Japan”, Acta Otolaryngol.,
135(8):853-8. (2015)(101) Sakashita T, Homma A, Hatakeyama H, Furusawa J, Kano S, Mizumachi T, Iizuka S, Onimaru
R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S: “Clinical outcomes of weekly cisplatinchemoradiotherapy for patients with pyriform sinus cancer”, Int J Clin Oncol., 20(6):1081-5. (2015)(102) Fujima N, Kudo K, Tsukahara A, Yoshida D, Sakashita T, Homma A, Tha KK, Shirato H:“Measurement of tumor blood flow in head and neck squamous cell carcinoma by pseudocontinuous arterial spin labeling: comparison with dynamic contrast-enhanced MRI”, J Magn
Reson Imaging, 41(4):983-91, (2015)(103) Homma A, Nakamaru Y, Sakashita T, Onimaru R, Terasaka S, Tsuchiya K, Yoshida D, Yasuda
K, Hatakeyama H, Furusawa J, Mizumachi T, Kano S, Shirato H, Fukuda S: “Management forsquamous cell carcinoma of the nasal cavity and ethmoid sinus: A single institution experience”,
Auris Nasus Larynx, 42(5):377-81, (2015)(104) Ishihara S, Yasuda M, Ishizu A, Ishikawa M, Shirato H, Haga H: “Activating transcription
factor 5 enhances radioresistance and malignancy in cancer cells”, Oncotarget, 10;6(7):4602-14(2015)(105) Yamaguchi S, Hirata K, Kaneko S, Kobayashi H, Shiga T, Kobayashi K, Onimaru R, Shirato H,
Tamaki N, Terasaka S, Houkin K: “Combined use of 18 F-FDG PET and corticosteroid for
diagnosis of deep-seated primary central nervous system lymphoma without histopathologicalconfirmation”, Acta Neurochir (Wien), 157(2):187-94 (2015)(106) Mizumachi T, Homma A, Kakizaki T, Sakashita T, Kano S, Hatakeyama H, Tsuchiya K, Yasuda
K, Onimaru R, Shirato H, Taguchi J, Shimizu Y, Kinoshita I, Akita H, Fukuda S: “Feasibility andefficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined withconcurrent weekly cisplatin chemoradiotherapy for locally advanced head and neck squamous cell
carcinoma”, Int J Clin Oncol., 20(3):431-7 (2015)(107) Ishizaka K, Kato F, Terae S, Mito S, Oyama-Manabe N, Kamishima T, Nakanishi M, Sugimori
H, Hamaguchi H, Shirato H: “Bilateral breast MRI by use of dual-source parallel radiofrequency
excitation and image-based shimming at 3 Tesla: improvement in homogeneity on fat-suppression
imaging”, Radiol Phys Technol., 8(1):4-12 (2015)(108) Kato F, Oyama-Manabe N, Sakuhara Y, Mito S, Takahashi M, Sakamoto T, Hosoda M, Terae S,
Shirato H: “Earlier and better high-resolution single breast imaging during bilateral breast
dynamic scans at 3-T MRI: comparison with post dynamic high-resolution imaging”, Breast
Cancer, 22;5:475-479 (2015)(109) Hirata Y, Miyamoto N, Shimizu M, Yoshida M, Hiramoto K, Ichikawa Y, Kaneko S, Sasagawa
T, Hiraoka M, Shirato H: “International standardization of four dimensional radiotherapy system- Enhancement of effects of irradiation and assurance of safety”, Synthesiology-English edition,
7(4): 229-238 (2015) *ii)
(110) Watanabe S, Okamoto S, Shiga T, Inoue T, Hirata K, Magota K, Nishijima K, Kuge Y, Shirato
H, Tamaki N: “Respiratory-gated FMISO-PET CT for the quantitative evaluation of hypoxia in
non-small cell lung cancer”, J Nucl Med., 127(56):3 (2015)(111) Watanabe S, Okamoto S, Shiga T, Inoue T, Hirata K, Magota K, Nishijima K, Kuge Y, Shirato
H, Tamaki N: “Respiratory-gated FMISO-PET/CT detects tumor hypoxia with higher sensitivity
in non-small cell lung cancer”, Eur J Nucl Med Mol Imaging., OP144;42:S61-S61 (2015)(112) Fujima N, Nakamaru Y, Sakashita T, Homma A, Tsukahara A, Kudo K, Shirato H:“Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR
perfusion imaging”, Dentomaxillofac Radiol., 44(9):20150074. (2015) *i)(113) Harada T, Abe T, Kato F, Matsumoto R, Fujita H, Murai S, Miyajima N, Tsuchiya K, Maruyama
S, Kudo K, Shinohara N: “Five-point Likert scaling on MRI predicts clinically significant prostate
carcinoma”, BMC Urol., 4;15:91, (2015)81

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(114) Homma A, Sakashita T, Hatakeyama H, Kano S, Mizumachi T, Nakamaru Y, Yoshida D,
Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S: “The efficacy of superselective intraarterial infusion with concomitant radiotherapy for adenoid cystic carcinoma of the head andneck”, Acta Otolaryngol., 135(9):950-4, (2015)(115) Shibasaki S, Takahashi N, Homma S, Nishida M, Shimokuni T, Yoshida T, Kawamura H,
Oyama-Manabe N, Kudo K, Taketomi A: “Use of transabdominal ultrasonography topreoperatively determine T-stage of proven colon cancers”, Abdom Imaging., 40(6):1441-50, (2015)(116) Manabe O, Hattori N, Yamaguchi S, Hirata K, Kobayashi K, Terasaka S, Kobayashi H, Motegi
H, Shiga T, Magota K, Oyama-Manabe N, Nishijima K, Kuge Y, Tamaki N: “Oligodendroglial
component complicates the prediction of tumour grading with metabolic imaging”, Eur J Nucl Med
Mol Imaging., 42, 896-904, (2015)(117) Mori Y, Manabe O, Naya M, Tomiyama Y, Yoshinaga K, Magota K, Oyama-Manabe N, Hirata
K, Tsutsui H, Tamaki N, Katoh C: “Improved spillover correction model to quantify myocardial
blood flow by 11C-acetate PET: comparison with 15O-H 2O PET”, Ann Nucl Med., 29(1):15-20,(2015)(118) Shimizu S, Nishioka K, Suzuki R, Shinohara N, Maruyama S, Abe T, Kinoshita R, Katoh N,
Onimaru R, Shirato H: “Early results of urethral dose reduction and small safety margin in
intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time
tumor-tracking radiotherapy (RTRT) system”, Radiat Oncol., 21;9(1):118, (2014)(119) Yamaguchi S, Terasaka S, Kobayashi H, Asaoka K, Motegi H, Nishihara H, Kanno H, Onimaru
R, Ito YM, Shirato H, Houkin K: “Prognostic factors for survival in patients with high-grade
meningioma and recurrence-risk stratification for application of radiotherapy” PLoS One.,
12;9(5):e97108. (2014)(120) Shimizu S, Miyamoto N, Matsuura T, Fujii Y, Umezawa M, Umegaki K, Hiramoto K, Shirato
H: “A proton beam therapy system dedicated to spot-scanning increases accuracy with moving
tumors by real-time imaging and gating and reduces equipment size”, PLoS One., 18;9(4) (2014)(121) Shimizu S, Matsuura T, Umezawa M, Hiramoto K, Miyamoto N, Umegaki K, Shirato H:“Preliminary analysis for integration of spot-scanning proton beam therapy and real-time imaging
and gating”, Phys Med., 30(5) 555-558 (2014)(122) Onodera S, Aoyama H, Tha KK, Hashimoto N, Toyomaki A, Terae S, Shirato H: “The value of
4-month neurocognitive function as an endpoint in brain metastases trials”, J Neurooncol.,120(2):311-319, (2014)(123) Kikuchi Y, Oyama-Manabe N, Naya M, Manabe O, Tomiyama Y, Sasaki T, Katoh C, Kudo K,
Tamaki N, Shirato H: “Quantification of myocardial blood flow using dynamic 320-row multidetector CT as compared with ¹⁵O-H₂O PET”, Eur Radiol., 24(7):1547-56, (2014)(124) Yamazaki R, Onimaru R, Katoh N, Inoue T, Nishioka T, ShiratoH, Date H: “Influence of
respiration on dose calculation in stereotactic body radiotherapy of the lung”, Radiol Phys Technol.,7(2):284-9, (2014)(125) Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima
N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Suzuki F, Fukuda S: “Salvage operations forpatients with persistent or recurrent cancer of the maxillary sinus after superselective intraarterial infusion of cisplatin with concurrent radiotherapy”, Br J Oral Maxillofac Surg, 52(4):3238, (2014)(126) Mahabir R, Tanino M, Elmansuri A, Wang L, Kimura T, Itoh T, Ohba Y, Nishihara H, Shirato
H, Tsuda M, Tanaka S: “Sustained elevation of Snail promotes glial-mesenchymal transition after
irradiation in malignant glioma”, Neuro Oncol., 16(5):671-85, (2014)(127) Sakashita T, Homma A, Hatakeyama H, Kano S, Mizumachi T, Furusawa J, Yoshida D, Fujima
N, Onimaru R, Tsuchiya K, Yasuda K, Shirato H, Fukuda S.: “The incidence of late neck recurrencein N0 maxillary sinus squamous cell carcinomas after superselective intra-arterial

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chemoradiotherapy without prophylactic neck irradiation”, Eur Arch Otorhinolaryngol.,271(10):2767-70. (2014)(128) Hirabayashi K, Kinugawa S, Yokota T, Takada S, Fukushima A, Suga T, Takahashi M, Ono T,
Morita N, Omokawa M, Harada K, Oyama-Manabe N, Shirato H, Matsushima S, Okita K, Tsutsui
H: “Intramyocellular lipid is increased in the skeletal muscle of patients with dilated
cardiomyopathy with lowered exercise capacity”, Int J Cardiol., 176:1110 (2014)(129) Fujima N, Kudo K, Yoshida D, Homma A, Sakashita T, Tsukahara A, Tha KK, Zaitsu Y, Terae
S, Shirato H: “Arterial spin labeling to determine tumor viability in head and neck cancer before
and after treatment”, J Magn Reson Imaging., 40(4):920-8 (2014)(130) Fujima N, Yoshida D, Sakashita T, Homma A, Tsukahara A, Tha KK, Kudo K, Shirato H:“Intravoxel incoherent motion diffusion-weighted imaging in head and neck squamous cell
carcinoma: Assessment of perfusion-related parameters compared to dynamic contrast-enhanced
MRI”, Magn Reson Imaging., 32(10):1206-1213, (2014)(131) Fatema CN, Zhao S, Zhao Y, Yu W, Nishijima K, Yasuda K, Kitagawa Y, Tamaki N, Kuge Y:“Dual tracer evaluation of dynamic changes in intratumoral hypoxic and proliferative states afterradiotherapy of human head and neck cancer xenografts using radiolabeled FMISO and FLT”,
BMC Cancer, 14:692 (2014)(132) Tha KK: “The directional metrics of diffusion”, J Radiol Radiat Ther, 2(2): 1030. (2014)

Published books(1)Shirato H, Taguchi H:“Radiation Therapy”,
Nishimurasyoten, Inc., 1341-1344, 2015

BasicsandClinical,Gstroenterology,

3) Verbal presentations- major presentations only.
- international conferences held in Japan are listed as " [International conference]".
Keynote speeches(1) Shirato H: “Painful years for particle beam therapists resulted in a little hope: Japaneseexperience”, The 5th Japan-Taiwan Radiation Oncology Symposium " No Pain, No Gain". Kobe,
May 20, 2017 [International conference](2) Shirato H: “From Real-time Tumor-Tracking Technology to Motion Science in Life”, The 75th
Annual Meeting of the Japanese Cancer Association, Yokohama, 2016.10.8 [Japanese
conference](3) Shirato H: “Present and future of proton beam therapy”, Sapporo, The 9th Specialist Seminar,
Hokkaido Branch of the Japanese Society of Gastroenterology Japanese GastroenterologicalEndoscopy Society, 2015.8.30 [Japanese conference](4) Shirato H: “Features and perspectives of radiation therapy and particle therapy”, Sapporo, The
13th Japanese Society of Medical Oncology 2015 Annual Meeting, 2015.7.17 [Japanese
conference](5) Shirato H: “An image-guided spot-scanning proton beam therapy gated to real-time tumortracking system”, 3rd ESTRO Forum Joint Symposium: ESTRO-JASTRO, Barcelona, Spain,
April 24-28, 2015 [International conference](6) Shirato H: “Quality of Radiotherapy; Treatment (Quality control, guidelines, standard
treatment)”, Yokohama, The 74th Annual Meeting of the Japan Radiological Society, 2015.4.19[Japanese conference](7) Umegaki K: “Development of gated spot scanning proton beam therapy system with real-time
tumor tracking.”, Busan (South Korea) BEXCO, The 7th Korea-Japan Joint Meeting on Medical,

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Physics, Plenary Symposium, 2014.9.25 [International conference]
Invited lectures [Japanese conference](1) Manabe N: “Findings in coronary artery pseudoaneurysms”, The 86th Study Meeting of Japan
Society of Cardiovascular Radiology, Tokyo, January 13, 2018 [Japanese conference](2) Manabe N: “We need to respond to every kind of cardiovascular disease! Beyond cardiac MRI”,
The 4th Gunma Cardiac MRI Study Meeting, Maebashi, January 18, 2018 [Japanese conference](3) Kudo K: “Improvements in QSM analysis and recently appearing topics”, Hi Advanced MRI
Seminar in Kansai, Osaka, February 3, 2018 [Japanese conference](4) Manabe N: “MRI of hypertrophic cardiomyopathy”, Cardiomyopathy Symposium, Tokyo,
February 17, 2018 [Japanese conference](5) Kudo K: “Acute phase diagnosis of cerebral ischemia”, The 43rd Japan Stroke Society Academic
Conference, Fukuoka, March 15, 2018 [Japanese conference](6) Manabe N: “Advantage of Comprehensive Myocardial Perfusion CT imaging”, The 82nd Annual
Scientific Meeting of the Japanese Circulation Society, Osaka, March 24, 2018 [Japanese
conference](7) Kudo K: “TBD”, The 77th Annual Meeting of the Japan Radiological Society, JCR Hour 2018,
Yokohama, April 15, 2018 (Scheduled) [Japanese conference](8) Kudo K: “Images in the acute phase of cerebral infarction (tentative)”, FAST Conference, Tokyo,
April 21, 2018.4.21 (Scheduled) [Japanese conference](9) Kudo K: “TBD”, The 59th Annual Meeting of the Japanese Society of Neurology ― Luncheon
seminar, Sapporo, May 24, 2018 (Scheduled) [Japanese conference](10) Kudo K: “Symptoms of Parkinson’s Disease: Focus on diagnostic imaging targeting the main
complaint”, The 59th Annual Meeting of the Japanese Society of Neurology ― Education course,
Sapporo, May 26, 2018 (Scheduled) [Japanese conference](11) Shirato H: “TBD”, The 77th Annual Meeting of the Japanese Cancer Association, Osaka,
September 28, 2018 (Scheduled) [Japanese conference](12) Kudo K: “Basics of analysis algorithms in Perfusion CT (Educational lecture)”, The 2nd
Pancreas Perfusion · Functional Imaging Study Group, Tokyo, January 28, 2017 [Japanese
conference](13) Manabe N: “Cardiac MRI”, Japanese College of Cardiology Fundamental Course, Osaka,February 19, 2017 [Japanese conference](14) Kudo K: “QSM: Newly available magnetic contrast features” (Symposium), The 40th Annual
Meeting of the Japan Society for CNS Computed Imaging, Kagoshima, March 3-4, 2017
[Japanese conference](15) Tha KK: “Noninvasive Assessment of Electrical Conductivity of Brain Tumors by MRI”
(Symposium, The 40th Annual Meeting of the Japan Society for CNS Computed Imaging)
Qualitative diagnosis of brain tumor - how far is it possible -, Kagoshima Sun Royal Hotel,
March 3-4, 2017 [Japanese conference](16) Manabe N: “Cardiac MRI”, The 34th Setouchi Cardiac CT / MR Study Meeting, Matsuyama,
March 12, 2017 [Japanese conference](17) Manabe N:“Diagnostic imaging of the myocardium with MRI”, The 9th Kyushu-Yamaguchi
Cardiovascular Imaging Study Group, Fukuoka, March 25, 2017 [Japanese conference](18) Tha KK: “Myself and Radiology Career” (Symposium), The 73rd Spring Congress of JapaneseSociety of Radiological Technology, Yokohama, April 16, 2017 [Japanese conference](19) Abo D, Soyama T, Morita R, Kudo K: “Trancecatheter Arterial Embolization (TAE) for
pulmonary arteriovenous malformation (PAVM) using a Detachable coil at Hokkaido University
Hospital”, The 46th Annual Meeting of the Japanese Society of Interventional Radiology,
Okayama, May 18, 2017 [Japanese conference]84

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(20) Abo D: “Drainage based on anatomical features – the upper abdomen –”, Technical education
seminar, The 46th Annual Meeting of the Japanese Society of Interventional Radiology, Okayama,
May 19, 2017 [Japanese conference](21) Kudo K: “Basics of quantitative magnetic susceptibility mapping (QSM) and its clinicalapplication”, Radiology Forum，Chuo，May 26, 2017 [Japanese conference](22) Manabe N: “Differential diagnosis of cardiomyopathy using cardiac MRI”, The 52nd
Educational Seminar, Japanese College of Cardiology Fundamental Course, Tokyo, May 28,
2017 [Japanese conference](23) Manabe N: “Cardiac involvement in patients with sarcoidosis”, The 11th Congress of AsianSociety of cardiovascular imaging, Kyoto, June 1-3, 2017 [Japanese conference](24) Kudo K: “Basics of MR examinations: central nerve / spinal area”, The 18th Introductory Studyof MR, Kyoto, June 10, 2017 [Japanese conference](25) Manabe N: “Recent topics for diagnostic imaging of the cardiac area”, The 31st The Hokkaido
Society of Nuclear Medicine Technology Seminar, June 17, 2017 [Japanese conference](26) Manabe N: “How very useful! Cardiac MRI”, Toyoake Heart Imaging Seminar, Nagoya, June22, 2017 [Japanese conference](27) Tha KK: “Radiomics in Cancer Research and Therapy” (Special lecture), The 23rd Annual
Meeting of Sensitization of Cancer Treatment Study Group, Karuizawa, July 15, 2017 *[Japanese conference](28) Kudo K: ““Progress of equipment / software”, MR”, SAMI 2017, Advanced Medical Imaging
Study Group. Osaka, July 22, 2017 [Japanese conference](29) Manabe N: “We have to fully understand this much in cardiac diagnostic imaging - The latest
technology”, The 33rd Japan Conference of Radiological Technologists / The 24th East Asia
Conference of Radiological Technologists, September 23, 2017 [Japanese conference](30) Kudo K: “MRI imaging with the stable oxygen isotope O-17”, The 2nd Hokkaido Kamui
Conference, Sapporo, September 2, 2017 [Japanese conference](31) Kudo K: “Current Topics of Cerebral Perfusion and Oxygen Metabolism Imaging”, Joint
Symposium, The 45th Annual Meeting of the Japanese Society of Magnetic Resonance in
Medicine – CSMRM – JSMRM, Utsunomiya, September 15, 2017 [Japanese conference](32) Kudo K: “New developments in QSM imaging and analysis”, Luncheon seminar, The 45th
Annual Meeting of the Japanese Society of Magnetic Resonance in Medicine – CSMRM –JSMRM, Utsunomiya, September 15, 2017 [Japanese conference](33) Kudo K: “MRI imaging with the stable oxygen isotope O-17”, The 33rd Brain Function Imaging
Conference，Kobe，September 23, 2017 [Japanese conference](34) Kudo K: “Advanced Neuro MR Imaging”, Hitachi Healthcare Global Partners Summit 2017，
Tokyo，October 12, 2017 [Japanese conference](35) Kudo K: “Full automated analysis of CT / MR perfusion images using PMA software”, The 60th
Annual Meeting of the Japanese Society of Cerebral Blood Flow and Metabolism, Osaka,
November 3, 2017 [Japanese conference](36) Kudo K: “Basic interpretation of brain MRI images - Focusing on cerebrovascular disorders
and brain metastasis”, The 2nd Medical Image Laboratory Lecture Meeting, Kushiro, November
7, 2017 [Japanese conference](37) Kudo K: “Brain CT / MRI for physicians and technicians not specializing in the central nervous
system – Focus on vascular disorders –“, MIL Diagnostic Imaging Seminar, Asahikawa,
November 16, 2017 [Japanese conference](38) Kudo K: “Magnetic susceptibility analysis of the brain and abdomen by a newly developed
QSM analysis method”, The 53rd Miyazaki MRI Study Meeting, Miyazaki, December 5, 2017
[Japanese conference](39) Abo D: “IVR meets post-surgical complications!”, Resident Seminar, Yokohama, April 16, 201685

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[Japanese conference](40) Shirato H: “Radiation therapy for cancers” (Special lecture) Radiation therapy for cancers, Tonan
Hospital, June 20, 2016 [Japanese conference](41) Katoh N: “Proton beam therapy for liver cancer (short lecture)”, The 27th Annual Meeting ofLiver Cancer Study Group of Hokkaido, Sapporo, June 25, 2016 [Japanese conference](42) Kudo K: “Evaluation of brain structure and oxygen metabolism by quantitative magnetic
susceptibility mapping (QSM) (Symposium)”, The 57th Annual Meeting of the Japanese Society of
Neurology, Kobe, May 18, 2016 [Japanese conference](43) Manabe N: “MRI findings based on cardiac sarcoidosis cases” AIMS Cardiac Imaging, Tokyo,
May 21, 2016 [Japanese conference](44) Kudo K: “Oxygen metabolism imaging by MRI (Educational lecture)”, The 72nd Annual Meetingof the Cerebral Nerve Image Study Group, Akita, May 27, 2016 [Japanese conference](45) Kudo K: “Basics of MR examinations: central nerve / spinal area (Educational lecture)”, The 17th
Introductory Study of MR, Tokyo, June 4, 2016[Japanese conference](46) Manabe N: “Potential of a One stop shop for cardiac CT”, The 14th Hokkaido Cardiac CT
Technical Seminar, Sapporo, June 15, 2016 [Japanese conference](47) Kudo K: “Structure and function of the brain depicted by QSM (Educational lecture)”, The 13th
Okayama Advanced Imaging Seminar, Okayama, July 2, 2016 [Japanese conference](48) Manabe N: “Evaluation of myocardial ischemia and coronary blood flow reserve capacity using
MRI”, The 26th Annual Meeting of the Japanese Society of Nuclear Cardiology, Tsu, July 16, 2016
[Japanese conference](49) Abo D: “Basic facts of radiation exposure”, The 2nd Imaging Seminar in Tokachi, Obihiro, August19, 2016 [Japanese conference](50) Manabe N: “New potentials for Cardiac MRI”, The 44th Annual Meeting of the Japanese Societyof Magnetic Resonance in Medicine, Omiya, September 9, 2016 [Japanese conference](51) Tha KK: “Current Aspects of Radiomics in Neuroimaging”, The 44th Annual Meeting of theJapanese Society of Magnetic Resonance in Medicine, Omiya, September 9, 2016 [Japanese
conference](52) Manabe N: “Latest clinical applications of the 320-area detector CT in the circulatory field”, The
64th Annual Scientific Session of the Japanese College of Cardiology, Fireside Symposium, Tokyo,
September 24, 2016 [Japanese conference](53) Manabe N: “Quantitative evaluation of myocardial blood flow and fibrosis using CT and MRI”,
Hokkaido Cardiovascular Hospital, Sapporo, September 26, 2016 [Japanese conference](54) Shimizu S: Spot scanning proton beam therapy using real-time image guided technology(Hokkaido and Sakhalin Joint Cancer Symposium), Hokkaido University School of Medicine,
Frate Hall, October 26-28, 2016 [Japanese conference](55) Kudo K: “Perfusion MRI: Challenges in clinical applications and future potentials including
QIBA (Educational lecture)”, Bayer Radiology Day, Osaka, October 29, 2016 [Japanese
conference](56) Manabe N: “How to scan? How to interpret? Cardiac MRI”, Bayer Image Diagnostic Web
Conference, Osaka, November 16, 2016 [Japanese conference](57) Kudo K: “CT / MR perfusion imaging (Educational lecture)”, Brain Research Seminar, Sapporo,
November 25, 2016 [Japanese conference](58) Manabe N: “Utility of CT and MRI in circulatory organs”, Sapporo Cardio Vascular Center,
Cardiovascular Clinic, Sapporo, November 29, 2016 [Japanese conference](59) Manabe N: “Solutions to understanding diagnostic images with chest pain!”, Obihiro Kosei
General Hospital Internship Seminar, Obihiro, December 16, 2016 [Japanese conference]86

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(60) Shimizu S: Radiation therapy and particle therapy among the options for cancer treatment,
The 30th Sapporo Winter Cancer Seminar, Sapporo Cancer Seminar Foundation, 2016.1.30[Japanese conference](61) Abo D: “The present state of non-vascular interventions in the hepatopancreatobiliary region in
our department”, The 17th Annual meeting of the Japanese Society of Hepato-Pancreato-Biliary
Study Group, Tomakomai, October 30, 2015 [Japanese conference](62) Shirato H: “New directions in particle beam therapy – From therapeutic science to health care
medicine”, Maehashi, The 28th Annual Meeting of the Japanese Society for Radiation Oncology,
2015.11.20 [Japanese conference](63) Umegaki K: “Development of the innovative proton beam therapy system through industryacademia collaboration”, Tokyo Medical and Dental University, medU-net Regulatory Science
Seminar, 2015.11.12 [Japanese conference](64) Shimizu S: “Mission of the innovative proton beam therapy system”, Hakodate, The 52nd
Annual Congress of Japan Municipal Hospital Association, 2015.10.9 [Japanese conference](65) Shimizu S: “The latest proton beam therapy system”, Morioka, Iwate Prefectural Information
Exchange Center, From photon beam therapy to particle beam therapy, The 51st Autumn
Assembly of the Japan Radiological Society, 2015.10.3 [Japanese conference](66) Umegaki K: “Proton beam therapy system using a real-time tumor monitoring system and spotscanning beam therapy – From development to clinical application”, Hokkaido University, The
110th Annual Meeting of the Japan Society of Medical Physics, Sapporo, 110th Japan Society of
Medical Physics, 2015.9.20 [Japanese conference](67) Shimizu S: “Callenge of the Global Station for Quantum Medical Science and Engineering.”,
Sapporo, 110th Japan Society of Medical Physics, 2015.9.19 [Japanese conference](68) Shimizu S: “Proton beam therapy.”, Patient Adovocate Program (PAP), Sapporo, The 13th
Japanese Society of Medical Oncology 2015 Annual Meeting, 2015.7.17 [Japanese conference](69) Umegaki K: “Development of the innovative proton beam therapy system – Implementation of
proton beam therapy at Hokkaido University and future development”, Kaderu Sapporo 2.7,
2014 Annual Meeting on Radioisotope and Radiation Research, 2014.10.31 [Japanese
conference](70) Shimizu S: “The world first spot scanning proton beam therapy with IGRT”, Sapporo
Convention Center, Educational Lecture at the 42nd Autumn Assembly of Japanese Society ofRadiological Technology, 2014.10.11 [Japanese conference]
Invited lectures [International conference](1) Manabe N: “Clinical application for cardiomyopathy”, Shiriraji CMR course，Bangkok, January
25-26, 2018 [International conference](2) Manabe N: “Tissue characterization”, Shiriraji CMR course，Bangkok, January 25-26, 2018
[International conference](3) Shimizu S: “Initial Clinical Experience for the Real-Time-Image Gated Proton（RGPT）System
in Hokkaido University”, Radiation Oncology Grand Rounds, Johns Hopkins University(Baltimore), September 21, 2017 [International conference](4) Matsuura T: “Physical Aspects for the RGPT System in Hokkaido University”, Radiation
Oncology Grand Rounds, Johns Hopkins University (Baltimore), September 21, 2017
[International conference](5) Kudo K: “Current Updates of QSM Sequence and Analysis”, 1st JKT（Japan-Korea-Taiwan）
Neuroradiology Workshop，Osaka，October 7, 2017 [International conference](6) Oyama-Manabe N: “CT coronaries combined with Perfusion: Does it add value to patient`s caseand outcome”, German Roentgen Congress, Leipzig, May 25-27, 2017 [International conference](7) Kudo K: “SWI and QSM in Stroke and Misery Perfusio KSMR”, Seoul, Korea, March 23-25, 201787

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(8) Kudo K: “Academic and Social Member Management” (Educational lecture), The 2nd AOSOR
Chiang Mai, Thailand, November 17-19, 2016 [International conference](9) Tha KK: “Tumors and cerebral white matter”, The 14th Annual Meeting of Myanmar
Radiological Society, Chatrium Hotel Royal Lake, Yangon, Myanmar, November 4, 2016
[International conference](10) Shimizu S: “Particle therapy – scanning method and gating for motion management.”, The 3rd
GI-CoRE Medical Science and Engineering Symposium. Radiation Oncology, Biology&IVR,
Sapporo, 2016.3.4 [International conference](11) Nam JM: “Targeting integrin signaling to improve the efficacy of radiation treatment on breast
cancer cells.”, The 3rd GI-CoRE Medical Science and Engineering Symposium. Radiation
Oncology, Biology&IVR, Sapporo, 2016.3.3 [International conference](12) Shimizu S: “Real time image-gated proton beam therapy.”, Seoul (South Korea), The 14th Seoul
Radiation Oncology Symposium: Updates in Image-Guided Radiation Therapy, 2015.10.30[International conference](13) Kudo K: Contrast Enhanced MRI for Brain Tumors, 10th AOCNR Fukuoka, Japan 2015.11.5[International conference](14) Tha KK: Identification of Noninvasive Biomarkers for Glioblastoma: The Role of “Radiomics”.
Taipei (Taiwan), NeuroImaging Summit., 2015.10.17 [International conference](15) Umegaki K, Shirato H: “Development of Real-time Image Gated Spot Scanning Proton Beam
Therapy (RGPT) system, National Taiwan University”, 2015 International Symposium on
Radiation Medicine 2015.10.4 [International conference](16) Shimizu S, Shirato H, Umegaki K, Hokin K: “Spot Scanning Proton beam therapy –State-ofthe-art technology.”, Yuzhno-Sakhalinsk (Russia), Sakhalin Cancer Conference.”, 2014.10.1-3[International conference]
Other presentations [Japanese conference](1) Furuya S, Manabe N, Manabe O, Ohira H, Aikawa T, Koyanagawa K, Naya M: “Is accumulationin the liver an appropriate threshold measure for metabolic volume measurements of cardiac
sarcoidosis lesions?”, The 28th Annual Meeting of Japanese Society of Cardiovascular Imaging &Dynamics, January 12-13, 2018 [Japanese conference](2) Yasuda K, Tsuchiya K, Hatakeyama H, Homma A, Shimizu Y, Furukawa H, Onimaru R, Akita H,
Fukuda S, Shirato H: “Treatment outcome after Radiation Therapy for Mucosal Malignant
Melanoma of Head and Neck”, The 76th Annual Meeting of the Japan Radiological Society,
Yokohama, April 13-16, 2017 [Japanese conference](3) Oyama-Manabe N: “Evaluation of delayed contrast-enhanced CT with iterative model-based
reconstruction in cardiac sarcoidosis: comparison with MRI”, The 76th Annual Meeting of theJapan Radiological Society, Yokohama, April 13-16, 2017 [Japanese conference](4) Kinoshita R, Shimizu S, Nishikawa Y, Nishioka K, Hashimoto T, Suzuki R, Shirato H: “Incidental
radiation dose to internal mammary lymph node in tangential breast irradiation: comparison of
calculation algorism” The 76th Annual Meeting of the Japan Radiological Society, Yokohama,
April 13-16, 2017 [Japanese conference](5) Morita R, Sakuhara Y, Katoh N, Abo D, Soyama T, Kudo K, Shirato H: “Percutaneous hepatic
fiducial marker implantation for Real-time Tumor-tracking Radiotherapy (RTRT)”, The 76th
Annual Meeting of the Japan Radiological Society, Yokohama, April 13-16, 2017 [Japanese
conference](6) Sasaki F, Nagasaki T, Masuyama K, Higashino K, Nakano S, Ishikawa M: “Comprehensive
evaluation of the accuracy of the 3-dimensional water phantom scanning axis using a kV imaging
device”, The 73rd Spring Congress of Japanese Society of Radiological Technology, Yokohama,
April 13-16, 2017 [Japanese conference]88

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(7) Ishikawa M, Nara K, Sutherland K, Takigami M, Asano T, Kojima H: “Improvements in dose
distribution analysis using dose gradient information”, The 113rd Annual Meeting of the Japan
Society of Medical Physics, Yokohama, April 13-16, 2017 [Japanese conference](8) Ogawara R, Ishikawa M: “Improvements in the tracking accuracy by volume of response analysis
using a Parallel plane PET device”, The 113rd Annual Meeting of the Japan Society of Medical
Physics, Yokohama, April 13-16, 2017 [Japanese conference](9) Nara K, Kojima H, Sutherland K, Ishikawa M: “A study of film resolution on the analysis of dose
distributions with filmed data”, The 113rd Annual Meeting of the Japan Society of Medical Physics,
Yokohama, April 13-16, 2017 [Japanese conference](10) Murayama Y, Baba K, Ogawara R, Ishikawa M: “Optical transport simulation for improvementof SOF detector using Geant”, The 113rd Annual Meeting of the Japan Society of Medical Physics,
Yokohama, April 13-16, 2017 [Japanese conference](11) Kobayashi Y, Myojin M, Yuki T, Ishikawa M: “Study on a new method to create CT value density
conversion tables for dose calculations using CBCT images”, The 113rd Annual Meeting of theJapan Society of Medical Physics, Yokohama, April 13-16, 2017 [Japanese conference](12) Fujii T, Matsuura T, Takao S, Miyamoto N, Hirayama S, Umegaki K, Shimizu S, Umekawa T,
Baba R, Shirato H: “Analysis software to evaluate deviation of water-equivalent thickness alongproton beam path between Plan CT and CBCT for proton therap”, The 113rd Annual Meeting of
the Japan Society of Medical Physics, Yokohama, April 13-16, 2017 [Japanese conference](13) Hirayama S, Matsuura T, Koyano H, Takao S, Fujii T, Miyamoto N, Shimizu S, Fujii Y, Yamada
T, Nihongi H, Umekawa T, Fujimoto R, Umegaki K, Shirato H: “The Retrospective Interplay EffectEvaluation for Real-time Image-gated Proton Therapy using the Fiducial Marker Motion andTreatment Machine Log”, The 113rd Annual Meeting of the Japan Society of Medical Physics,
Yokohama, April 13-16, 2017 [Japanese conference](14) Soyama T, Abo D, Morita R, Sakuhara Y, Kudo K, Tsujino I, Nakatani M: “A case of embolization
with AVP II for portopulmonary hypertension affected by congenital portosystemic shunt”, The
46th Annual Meeting of the Japanese Society of Interventional Radiology, Okayama, May 18-20,
2017 [Japanese conference](15) Yasuda K, Katoh N, Okamoto S, Kinoshita R, Shiga T, Mizumachi T, Hatakeyama H, Homma A,
Taguchi J, Shimizu Y, Mori T, Tsuchiya K, Shirato H: “Treatment results with external irradiation
including IMRT for the bone metastasis of differentiated thyroid tumors”, The 41st Annual
Meeting of Japan Society for Head and Neck Cancer, Kyoto, June 8-9, 2017 [Japanese conference](16) Kato F, Aoike S, Hakoishi S, Umiya Y, Yamashita K, Baba M, Ishida N, Manabe N, Kudo K:“Clinical utility of the blood flow analysis software PMView for mammary gland dynamic MRI: for
the Semi-automatic ROI function”, The 25th Annual Meeting of the Japanese Breast Cancer
Society, Fukuoka, July 13-15, 2017 [Japanese conference](17) Kikuchi H, Yoshino H, Kato F, Kudo K, Shirato H: “Development of a database and teaching files
for interpretation of autopsy images”, The 15th Annual Meeting of the Japan Society of Autopsy
Imaging, Tsu, August 26, 2017 [Japanese conference](18) Kato F, Ihira K, Nozaki A, Naka T, Matsuno Y, Watari H, Manabe N, Kudo K: “Two cases ofuterine cervical clear cell adenocarcinoma”, The 18th Japanese Society for the Advancement of
Women's Imaging Symposium, Awaji, September 1-2, 2017 [Japanese conference](19) Kikuchi H, Yoshino H, Kudo K, Kato F, Nasuhara Y, Shinagawa N, Shimizu Y, Tanaka S, Hyodoh
H, Matoba K, Mikami H, Tanaka S, Shirato H: “The roles of the autopsy imaging section andradiation diagnosticians at the Center for Cause of Death Investigations, Hokkaido University”,
The 53rd Autumn Assembly of the Japan Radiological Society, Matsuyama, September 8-10, 2017
[Japanese conference](20) Soyama T, Abo D, Kato D, Yoshino H, Morita R, Kudo K: “Five cases of postoperative abscesses
where drainage under ultrasonic guidance was possible for a transcutaneous transluminal fistula”,

89

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The 53rd Autumn Assembly of the Japan Radiological Society, Matsuyama, September 8-10, 2017
[Japanese conference](21) Morita R, Soyama T, Abo D, Kudo K: “Case presentations of collaboration with surgery and IVR
to improve survival rates”, The 9th Annual Meeting of the Japanese Society for acute Care Surgery
Sapporo, September 9, 2017 [Japanese conference](22) Miyamoto N, Suzuki R, Takao S, Matsuura T, Hirayama S, Fujii T, Tomioka S, Shimizu S,
Umegaki K, Shirato H: “Evaluation of measurement accuracy of novel monoscopic X-ray imaging
technique for three-dimensional target localization using multiple internal fiducial markers”, The
114th Annual Meeting of the Japan Society of Medical Physics, September 15-17, 2017 [Japanese
conference](23) Arai Y, Ueda H, Nakagawa H, Miyamoto N, Umegaki K: “Target tumor localization algorithm
using multiple fiducial markers for Real-time Tumor-tracking Radiation Therapy”, The 114th
Annual Meeting of the Japan Society of Medical Physics, September 15-17, 2017 [Japanese
conference](24) Nakagawa H, Miyamoto N, Hirayama S, Ueda H, Yokokawa K, Umegaki K: “Evaluation of
dosimetric error with utilizing respiratory motion modeling aimed for beam angle optimization in
proton beam therapy”, The 114th Annual Meeting of the Japan Society of Medical Physics,
September 15-17, 2017 [Japanese conference](25) Hirayama S, Matsuura T, Ueda H, Takao S, Koyano H, Fujii T, Miyamoto N, Shimizu S, Fujii Y,
Fujimoto R, Umegaki K, Shirato H: “Evaluation of the sensitivity to variable RBE considering
LET dependence for the robust optimization and the PTV-based optimization”, The 114th Annual
Meeting of the Japan Society of Medical Physics, September 15-17, 2017 [Japanese conference](26) Fujii T, Matsuura T, Takao S, Hirayama S, Miyamoto N, Umegaki K, Shimizu S, Umekawa T,
Shirato H: “Evaluation of Water-Equivalent-Thickness (WET) deviation between Plan CT and Replan CT for prostate cancer in Spot-Scanning Proton-beam Therapy”, The 114th Annual Meetingof the Japan Society of Medical Physics, September 15-17, 2017 [Japanese conference](27) Murayama Y, Baba K, Kuga Y, Ishikawa M: “Study for the development of a single probe SOF
detector using a C-MOS camera”, The 14th Congress on Neutron Capture Therapy, Koriyama,
September 29-30, 2017 [Japanese conference](28) Baba K, Murayama Y, Ishikawa M: “Basic Study of the Bonner Sphere Spectrometer using a SOF
Detector with particle transport calculation code Geant 4”, The 14th Congress on Neutron Capture
Therapy, Koriyama, September 29-30, 2017 [Japanese conference](29) Hashimoto T, Terasaka S, Iguchi A, Yamaguchi S, Kobayashi H, Sugiyama M, Cho Y, Mori T,
Takao S, Matsuura T, Onimaru R, Shimizu S, Shirato H: “Two cases of AYA germ cell tumors where
intensity modulated proton beam irradiation (IMPT) of the entire skull and vertebra was usefulin reducing myelosuppression”, The 59th Annual Meeting of the Japanese Society of PediatricHematology / Oncology, Ehime, November 9-11, 2017 [Japanese conference](30) Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T,
Shirato H, Nam JM: “Targeting integrins with RGD-conjugated gold nanoparticles in radiation
therapy”, The 30th Annual Meeting of the Japanese Society for Radiation Oncology, November 1719, 2017 [Japanese conference] *i) ii)(31) Yasuda K, Katoh N, Okamoto S, Kinoshita R, Shiga T, Mizumachi T, Homma A, Taguchi J,
Shimizu Y, Mori T, Shirato H: “Treatment results with external irradiation for thyroid
differentiated cancer bone metastasis”, The 30th Annual Meeting of the Japanese Society for
Radiation Oncology, November 17-19, 2017 [Japanese conference](32) Mori T, Hashimoto T, Katoh N, Kinoshita R, Nishioka K, Nishikawa Y, Uchinami Y, Shane PY,
Onimaru R, Shimizu S, Shirato H: “Initial report on the acceptance of non-Japanese patients
undergoing proton beam treatment at Hokkaido University”, The 30th Annual Meeting of theJapanese Society for Radiation Oncology, November 17-19, 2017 [Japanese conference]90

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(33) Hashimoto T, Mori T, Takao S, Matsuura T, Onimaru R, Shimizu S, Shirato H: “Three cases of
AYA germ cell tumors where intensity modulated proton beam irradiation (IMPT) of the entire
vertebra was useful in reducing myelosuppression”, The 30th Annual Meeting of the JapaneseSociety for Radiation Oncology, November 17-19, 2017 [Japanese conference](34) Nishioka K, Goto K, Shimizu S, Matsuura T, Takao S, Hashimoto T, Kinoshita R, Nishikawa Y,
Shirato H: “Correlation between fluctuations in urine volume and positional changes in theprostate during radiotherapy”, The 30th Annual Meeting of the Japanese Society for Radiation
Oncology, November 17-19, 2017 [Japanese conference](35) Katoh N: “Stereotactic body / ablative radiotherapy and proton beam therapy for liver cancer”(Symposium), The 75th Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17,
2016 [Japanese conference](36) Kudo K: “Brain Structures and Oxygen Metabolism Visualized by Quantitative Susceptibility
Mapping” (QSM) (Luncheon, oral presentation), The 75th Annual Meeting of the Japan
Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](37) Kudo K: “Training in report creation from images-reading of report ― Moving beyond theframework of the teaching file ―” (Luncheon, oral presentation), The 75th Annual Meeting of theJapan Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](38) Manabe N: “MRI-based myocardial quantitative evaluation”, The 75th Annual Meeting of theJapan Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](39) Manabe N: “Clinical impact of 320-row area detector CT- myocardial perfusion imaging”, The
75th Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17, 2016 [Japanese
conference](40) Abo D, Sakuhara Y, Soyama T, Morita R, Kimira T, Kudo K: “Local recurrence rate ofultraselective transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma(HCC)”, The 75th Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17, 2016
[Japanese conference](41) Tha KK, Yamaguchi S, Terasaka S, Fujima N, Kudo K, Shirato H: “Performance of Major
Diffusion Metrics in Distinguishing Lymphomas and Glioblastomas”, The 75th Annual Meetingof the Japan Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](42) Inoue T, Okamoto S, Watanabe S, Yasuda K, Katoh N, Harada K, Shiga T, Tamaki N, Kuge Y,
Shirato H: “18F-fluoromisonidazole PET/CT for stage I non-small cell lung cancer treated bystereotactic body radiotherapy”, The 75th Annual Meeting of the Japan Radiological Society,
Yokohama, April 14-17, 2016 [Japanese conference](43) Katoh N, Shimizu S, Nishioka K, Hashimoto T, Inoue T, Matsuura T, Takao S, Onimaru R,
Umegaki K, Shirato H: “Spot-scanning proton beam therapy (SSPT) with or without the use of areal-time tumor-tracking function: Clinical Experience”, The 75th Annual Meeting of the Japan
Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](44) Mori T, Onimaru R, Kobayashi K, Yasuda K, Toyonaga T, Manabe O, Hirata K, Shiga T, Tamaki
N, Shirato H: “8F-labeled fluoromisonidazole (FMISO) positron emission tomography for
pretreatment evaluation of hypoxia in metastatic brain tumor”, The 75th Annual Meeting of theJapan Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](45) Morita R, Mori N, Kimura T, Soyama T, Ogawa K, Shimamura T, Abo D, Sakuhara Y, Kudo K:“Percutaneous embolization for hepatic encephalopathy due to portosystemic shunts”, The 75th
Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17, 2016 [Japanese
conference](46) Kinoshita R, Nishikawa Y, Nishioka K, Hashimoto T, Shimizu S, Suzuki R, Shirato H: “Dosevolume analysis of the lung and heart in breast tangential irradiation”, The 75th Annual Meetingof the Japan Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](47) Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Ishioka K, Yoshimura T,

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Umegaki K, Shirato H: “Evaluation of dose rates and irradiation times of real-time image
synchronized proton beam therapy for hepatic tumors with respiratory movement” The 75th
Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17, 2016 [Japanese
conference](48) Kato F, Mito S, Manabe N, Mori T, Umiya Y, Hasehawa K, Yamashita K, Kudo K: “Utility of the
PMView technique in blood flow analysis at the 3T mammary gland using dynamic contrastenhanced MRI” The 75th Annual Meeting of the Japan Radiological Society, Yokohama, April 1417, 2016 [Japanese conference](49) Nakagawa J, Kato F, Tanaka N, Mito S, Manabe N, Kudo K, Hosoda M, Yamashita K: “Study ofearly phase contrast-enhanced mammary gland MRI” The 75th Annual Meeting of the Japan
Radiological Society, Yokohama, April 14-17, 2016 [Japanese conference](50) Harada T, Kudo K, Ueno I, Yamashita N, Kameda H, Matsuda T, Sasaki M, Shirato H:“Improved Homogeneity of B1+ and Signal Intensity at 7T Using Parallel Transmission on Human
Volunteers” The 75th Annual Meeting of the Japan Radiological Society, Yokohama, April 14-17,
2016 [Japanese conference](51) Soyama T, Abo D, Kimura T, Morita R, Sakuhara Y, Kudo K: “Experience with initial use ofsteering microcatheters”, The 45th Annual Meeting of the Japanese Society of Interventional
Radiology, Nagoya, May 26-28, 2016 [Japanese conference](52) Morita R, Mori N, Kimura T, Soyama T, Abo D, Sakuhara Y, Kudo K: “A study on the outcomesof percutaneous embolization for hepatic encephalopathy”, The 45th Annual Meeting of theJapanese Society of Interventional Radiology, Nagoya, May 26-28, 2016 [Japanese conference](53) Abo D, Sakuhara Y, Soyama T, Morita R, Kimura T, Kudo K: “Local recurrence rate ofultraselective transcatheter arterial chemoembolization (TACE)for hepatocellular carcinoma(HCC)”, The 45th Annual Meeting of the Japanese Society of Interventional Radiology, Nagoya,May 26-28, 2016 [Japanese conference](54) Sakuhara Y, Nishio S, Soyama T, Abo D, Morita R, Kimura T, Kudo K: “An exploratory study oftranscatheter arterial embolization with microspheres for symptomatic enlarged polycystic liver.
(Featured abstracts)”, The 45th Annual Meeting of the Japanese Society of Interventional
Radiology, Nagoya, May 26-28, 2016 [Japanese conference](55) Kimura T, Morita R, Soyama T, Abo D, Sakuhara Y, Kudo K: “Percutaneous transhepatic stentplacement for symptomatic portal venous stenosis after surgical treatment for pancreatic andbiliary malignancies. (Featured abstracts)”, The 45th Annual Meeting of the Japanese Society ofInterventional Radiology, Nagoya, May 26-28, 2016 [Japanese conference](56) Soyama T, Sakuhara Y, Jeff Wang: “Innovative ultrasonic training system: Development of adigital/real hybrid phantom”, The 89th Annual Scientific Meeting of the Japan Society of
Ultrasonics in Medicine, Kyoto, May 27-29, 2016 [Japanese conference](57) Yasuda K, Okamoto S, Nishikawa Y, Ito Y, Shiga T, Inoue T, Mori T, Toyonaga T, Onimaru R,
Watanabe S, Tsuchiya K, Takeuchi W, Katoh N, Kuge Y, Tamaki N, Shirato H: “Integration of
Molecular Imaging into Treatment Planning of Radiotherapy”, The 11th Annual Scientific
Meeting of the Japanese Society for Molecular Imaging, Kobe, May 28-29, 2016 [Japanese
conference](58) Yasuda K, Nishikawa Y, Okamoto S, Ito Y, Tsuchiya K, Shiga T, Onimaru R, Kuge Y, Tamaki N,
Shirato H: “Analysis on FMISO-PET and radiotherapy for nasopharyngeal cancer”, The 40th
Annual Meeting of Japan Society for Head and Neck Cancer [Japanese conference](59) Kato F, Kudo K, Fujiwara T, Jeff W, Sugimori H, Yamashita K, Hosoda M, Manabe N, Mimura
R, Shirato H: “Evaluation of invasive breast cancer using diffusion kurtosis imaging of 3T
mammary gland MRI: Comparison of biomarkers in axillary lymph node metastasis”, The 24th
Annual Meeting of the Japanese Breast Cancer Society, Tokyo, June 16-18, 2016 [Japanese
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(60) Yabusaki T, Manabe N, Mitsuhashi T, Kuwatani M, Kawakami H, Sakamoto K, Mimura R, Kato
F, Kudo K: “A Case of an Oncocytic-type IPMN-derived mucinous carcinoma of the pancreas”, The
30th Annual Meeting of Japanese Society of Abdominal Radiology, June 24-25, 2016 [Japanese
conference](61) Tsuneta S, Yabusaki T, Kato F, Manabe N, Kudo K, Hatanaka K: “A case of a large
Cholangiolocellular carcinoma with problematic preoperative diagnosis”, The 30th Annual
Meeting of Japanese Society of Abdominal Radiology, June 24-25, 2016 [Japanese conference](62) Yamaguchi A, Yabusaki T, Kato F, Okada H, Orimo T, Harada T, Sakamoto K, Mimura R,
Manabe N, Shirato H: “Four cases considered as spontaneous regressions of hepatocellular
carcinomas”, The 30th Annual Meeting of Japanese Society of Abdominal Radiology, June 24-25,
2016 [Japanese conference](63) Kato F, Mimura R, Takeda M, Konno Y, Sasaki T, Watari H, Sakuragi N, Sakamoto K, Yabusaki
T, Kikuchi H, Manabe N, Kudo K: “A case of a foreign object in the vagina of a child”, The 17th
Annual Symposium Japanese Society for the Advancement of Women’s Imaging, Awaji, September
2-3, 2016 [Japanese conference](64) Mimura R, Kudo K, Shimada C, Konno Y, Shirai S, Manabe N, Watari H, Sakuragi N, Sasaki
H, Kudo K, Shirato H: “A case of a mature cystic teratoma complicated with anti-NMDA Receptor
encephalitis, which was difficult to diagnose preoperatively”, The 17th Annual Symposium
Japanese Society for the Advancement of Women’s Imaging, Awaji, September 2-3, 2016 [Japanese
conference](65) Miyamoto N, Suzuki R, Takao S, Matsuura T, Matsuzaki Y, Fujii T, Tomioka S, Shimizu S,
Umegaki K, Shirato H: “Efficiency improvement in patient positioning / gated irradiation in realtime tumor tracking radiotherapy using respiratory phase evaluations by analysis of threedimensional in vivo marker tracking” The 112th Japan Society of Medical Physics, Okinawa
2016.9.8-10 [Japanese conference](66) Ishikawa M, Fuwa M, Nara K, Sutherland K, Suzuki R, Miyamoto N: “A study on the effect ofimage filters with filmed data in dose distribution analysis”, The 112th Japan Society of Medical
Physics, Okinawa 2016.9.8-10 [Japanese conference](67) Fujima N, Okuaki T, Aoike T, Aoike S, Sugimori H, Kudo K: “Evaluation of water permeability
for ischemic lesion in the brain using DW-ASL”, The 44th Annual Meeting of the Japanese Society
for Magnetic Resonance in Medicine, September 9, 2016 [Japanese conference](68) Kikuchi H, Manabe N, Kato F, Mimura R, Sakamoto K, Habusaki T, Kudo K: “Coronary flow
velocity reserve on left main trunk using 3T-MRI can predict coronary artery disease as 15Olabeled Water PET”, The 44th Annual Meeting of the Japanese Society for Magnetic Resonance in
Medicine, September 9, 2016 [Japanese conference](69) Harada T, Kudo K, Shirai T, Bito Y, Shichinohe H, Tan C, Wan Z, Houkin K, Shirato H:“Quantitative measurement of susceptibility/R2* values of SPIO-labeled bone marrow stromalcells in gel phantom”, The 44th Annual Meeting of the Japanese Society for Magnetic Resonancein Medicine, September 9, 2016 [Japanese conference](70) Hashimoto T, Iguchi A, Terasaka S, Sugiyama M, Oshima J, Yamaguchi S, Kobayashi H, Cho Y,
Shimizu S, Onimaru R, Shirato H: “Arrangements at Hokkaido University Hospital for childhood
cancers using proton beam therapy”, The 68th Annual Meeting of Northern Japan PediatricSociety, Hirosaki, September 9-10, 2016 [Japanese conference](71) Soyama T, Abo D, Morita R, Sakuhara Y, Kudo K: “Two cases with effective steering of micro
catheters”, The 52nd Autumn Assembly of the Japan Radiological Society, Tokyo, September 1-19,
2016 [Japanese conference](72) Wu PH, Onodera Y, Ichikawa Y, Watanabe Y, Hashimoto T, Shirato H, Nam JM: “Effect of theinvasiveness of RGD Modified gold nano-particles on breast cancer cells after irradiation”, The
75th Annual Meeting of the Japanese Cancer Association, Yokohama, October 8-8, 2016 [Japanese93

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conference] *i)(73) Takeda M, Yamazawa H, Izumi G, Sasaki O, Abe J, Sasaki D, Aikawa T, Kikuchi H, Manabe N:“Early diagnosis of cardiomyopathy - Duchenne / Becker muscular dystrophy using quantitativeevaluations in cardiac MRI delayed contrast imaging”, The 25th Annual Meeting of the JapaneseSociety of Pediatric Myocardial Diseases, Tokyo, October, 8, 2016 [Japanese conference](74) Tamura H, Inoue T, Miyamoto N, Suzuki R, Fujita K, Hotta K: “Influence of intra-fractionalorgan motion on the IMRT of the esophagus”, The 44th Autumn Congress of Japanese Society ofRadiological Technology, Omiya, October, 13-15, 2016 [Japanese conference](75) Miyamoto N, Takao S, Matsuura T, Matsuzaki Y, Suzuki R, Inoue T, Katoh N, Onimaru R,
Shimizu S, Shirato H: “Evaluation of reproducibility of lung deformation due to respiration using
trajectory data of multiple in vivo markers”, The 29th Annual Meeting of the Japanese Society for
Radiation Oncology, November, 25-27, 2016 [Japanese conference](76) Hashimoto T, Tsuruga K, Kobayashi H, Iguchi A, Honda S, Sugiyama M, Yasuda K, Miyagi H,
Yamaguchi S, Fujita N, Oshima J, Cho Y, Onimaru R, Shimizu S, Terasaka S, Morimoto Y, Shirato
H: “Two cases of childhood cancer where proton beam therapy was performed under endotracheal
general anesthesia”, The 58th Annual Meeting of the Japanese Society of Pediatric Hematology /Oncology, Tokyo, December 15-17, 2016 [Japanese conference](77) Nam JM, Onodera Y, Sabe H, Shirato H: “Analysis of molecular mechanism involved inmaintenance of 3-dimensional structure on radiation treated mammary epithelial cells.”, Nagoya,The 74th Annual Meeting of the Japanese Cancer Association, 2015.10.8-10 [Japanese conference](78) Tha KK, Katscher U, Stehning C, Yamaguchi S, Terasaka S, Yamamoto T, Kudo K, Shirato H:“The Electrical Conductivity Characteristics of Glioma and Potential Usefulness of Noninvasive
Electrical Conductivity Measurement in Evaluation of Glioma.”, Tokyo, JSMRM 43rd Annual
Meeting, 2015.9.10-12 [Japanese conference](79) Kudo K: “Perfusion MRI for the Diagnosis of Brain Tumors.”, Tokyo, Advanced Neuroimaging
Workshop, 2015.5.23 [Japanese conference](80) Matsuura T, Fujii Y, Takao S, Matsuzaki Y, Yamada T, Matsuo Y, Fujitaka S, Takayanagi T,
Umegaki K, Shirato H: “Development of an range compensator for spot-scanning proton therapy
using real-time gating system.”, Yokohama, 109th Japan Society of Medical Physics, 2015.4.16-19[Japanese conference](81) Tha KK, Ulrich K, Stehning C, Yamaguchi S, Terasaka S, Sugimori H, Yamamoto T, Fujima N,
Kudo K, Suzuki Y, van Cauteren M, Shirato H: “Electrical Conductivity Characteristics ofMeningiomas: Noninvasive Assessment using Electric Properties Tomography.”, Nagoya, Japan
Society of Neuroradiology 44th Annual Meeting, 2015.3.6-7 [Japanese conference](82) Tha KK, Katscher U, Yamaguchi S, Terasaka S, Stehningn C, Fujima N, Kudo K, Shirato H:“Electrical conductivity characteristics of meningiomas: the results of a noninvasive assessment.”,
Nagoya, Japan Society of Neuroradiology 44th Annual Meeting, 2015.3.6 [Japanese conference](83) Yasuda K, Tsuchiya K, Onimaru R, Harada Y, Harada K, Nishikawa Y, Kinoshita R, Tsuji S,
Horita K, Suzuki R, Shirato H: “Effects of narrow CTV-PTV margin on variability of radiationdose prescription in cases that CTV was close to OAR.”, Yokohama, The 27th annual meeting ofJapanese Society for Radiation Oncology (JASTRO), 2014.11.13 [Japanese conference](84) Nam JM, Onodera Y, Sabe H, Shirato H: “Analysis of molecular mechanism involved ininvasiveness of radiation treated breast cancer cells.”, Yokohama, The 73th Annual Meeting of theJapanese Cancer Association, 2014.9.25-27 [Japanese conference](85) Inoue T, Katoh N, Shimizu S, Suzuki R, Sasaki T, Fukusima H, Komatsu Y, Shirato H.
Chemoradiation therapy using intensity-modulated radiation therapy for locally advanced
esophageal carcinoma.”, Yokohama, The 73rd Annual Meeting of the Japan Radiological Society.
2014.4.10-13 [Japanese conference]

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Other presentations [International conference](1) C Sanli, T Matsuura, L Xing, M Unlu: “Comparison of Acoustic Waves Generated in Proton andCarbon Ion Therapy” AAPM Annual Meeting 2018, Nashville, 2018.7.29-8.2 [International
conference](2) C Sanli, J Wang, M Unlu: “Absorption Dependence of the X-Ray Induced Acoustic Waves”, AAPM
Annual Meeting 2018, Nashville, 2018.7.29-8.2 [International conference] *i)(3) Wu PH, Onodera Y, Giaccia AJ, Le QT, Shirato H, Nam JM: “Radiation increases invasive activityof breast cancer cells via altering lysosome exocytosis”. AACR Annual Meeting 2018. Chicago,
2018. 4. 14-18 [International conference] *i)(4) Tha KK: “Identification of Noninvasive Biomarkers for Glioblastoma: The Role of“Radiomics”
GI-CoRE GSQ, GSB & IGM JOINT SYMPOSIUM: Quantum, Informatics, Biology & Medicine (5th GSQ
Symposium & 1st GSB Symposium)，Sapporo, July 10-11, 2017 [International conference]*i)(5) Nam JM, Hsieh CC: “Molecular targets for suppression of cancer invasion”, GI-CoRE GSQ, GSB & IGM JOINTSYMPOSIUM: Quantum, Informatics, Biology & Medicine (5th GSQ Symposium & 1st GSB Symposium)，
Sapporo, July 10-11, 2017 [International conference] *i)(6) Wu PH, Onodera Y, Ichikawa Y, Watanabe Y, Wei Q, Hashimoto T, Shirato H, Nam JM: “RGDconjugated gold nanoparticles in radiotherapy decreases the invasion activity in breast cancer
cells.”, Sapporo, The 3rd GI-CoRE Medical Science and Engineering Symposium. Radiation
Oncology, Biology&IVR, 2016.3.3-4 [International conference](7) Wu PH, Onodera Y, Ichikawa Y, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM: “Effectsof RGD peptide conjugated gold nanoparticles in Breast Cancer Cells with ionization radiation.”,San Diego, ASCB Annual meeting, San Diego (U.S.A.), 2015.12.12-16 [International conference](8) Shimizu S, Katoh N, Nishioka K, Hashimoto T, Inoue T, Matsuura T, Takao S, Matsuzaki Y,Fujii
Y, Tamura M, Onimaru R, Umegaki K, Shirato H: “Initial clinical experience of spot-scanning
proton beam therapy using real-time-image gated proton-beam therapy system.”, Dresden(Germany), 4D Treatment Planning Workshop 2015, 2015.11.26-27 [International conference](9) Matsuura T, Takao S, Matsuzaki Y, Fujii Y, Fujii T, Miyamoto N, Katoh N, Shimizu S, Shirato H,
Umegaki K: “Treatment of superficial liver tumors with spot-scanning proton therapy using realtime gating system-comparison between range compensation devices.”, OncoRay, Dresden(Germany), 7th International 4D Treatment Planning Workshop, 2015.11.26-27 [International
conference](10) Shimizu S, Katoh N, Takao S, Matsuura T, Miyamoto N, Hashimoto T, Nishioka K, Yoshimura
T, Matsuzaki Y, Kinoshita R, Nishikawa Y, Onimaru R, Umegaki K, Shirato H: “Treatment of
respiratory moving liver tumor using gated spot scanning proton beam therapy system withreal-time tumor-tracking function.”, San Antonio (U.S.A.), ASTRO 57th Annual meeting,2015.10.18-21 [International conference](11) Umegaki K, Matsuura T, Takao S, Matsuzaki Y, Yamada T, Fujii Y, Miyamoto N, Shimizu S,
Shirato H: “Startup experience of the new proton beam therapy with gated spot scanning andreal-time tumor-tracking.”, Anaheim (U.S.A.), 57th AAPM Annual Meeting, 2015.7.16[International conference](12) Matsuura T, Fujii Y, Takao S, Yamada T, Matsuzaki Y, Miyamoto N, Takayanagi T, Fujitaka S,
Shimizu S, Shirato H, Umegaki K: “Development of An Applicator for Treating Shallow andMoving Tumors with Respiratory-Gated Spot-Scanning Proton Therapy Using Real-Time Image
Guidance”, Anaheim (U.S.A.), 57th AAPM Annual Meeting, 2015.7.12-16 [International
conference](13) Tha KK, Katscher U, Stehning C, Yamaguchi S, Terasaka S, Shirato H: “Electrical Conductivity
Characteristics of Glioma and Potential Usefulness of Noninvasive Electrical Conductivity
Measurement in Evaluation of Glioma.”, Chicago (U.S.A.), 101st Annual Meeting of RSNA,
2015.11.29 [International conference]95

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(14) Wang J, Kato F, Yamashita H, Malkov S, Shepherd J, Kudo K, Shirato H: “Volumetric Breast
Density of Japanese Women Using Adaptive Pattern Recognition-Based Calibrations.”, San
Francisco (U.S.A.), 7th International Workshop on Breast Densitometry and Cancer Risk
Assessment, 2015.6.10-12 [International conference](15) Kudo K, Uwano I, Hirai T, Nakamura H, Fujima N, Yamashita F, Goodwin J, Higuchi S, Sasaki
M: “Diagnostic Performance of Dynamic Susceptibility Contrast Perfusion in Glioma Grading:Comparison of Cerebral Blood Volume among Different Analysis Software.”, Tronto (Canada),
23rd ISMRM, 2015.6.1-5 [International conference](16) Tha KK, Ulrich K, Stehning C, Yamaguchi S, Terasaka S, Sugimori H, Yamamoto T, Fujima N,
Kudo K, Suzuki Y, van Cauteren M, Shirato H: “Electrical Conductivity Characteristics ofMeningiomas: Noninvasive Assessment using Electric Properties Tomography.”, Toronto (Canada),
ISMRM 23rd Annual Meeting & Exhibition, 2015.5.30-6.5 [International conference](17) Kudo K: “Perfusion MRI for the Diagnosis of Brain Tumors.”, Seoul (South Korea), KSMRM,
2015.3.27-28 [International conference](18) Wang J, Kato F, Kudo K, Yamashita H, Shirato H: “Heterogeneity of Background Parenchymal
Enhancement on MRI Strongly Predictive of Breast Cancer Molecular Subtypes.”, Chicago(U.S.A.), 100th Annual Meeting of RSNA , 2014.11.30-12.5 [International conference](19) Kudo K: “Oxygen Extraction Fraction (OEF) Measurement using Quantitative Susceptibility
Mapping (QSM).”, Kobe, 15th AOCR, 2014.9.24 [International conference](20) Shimizu S, Takao S, Matsuura T, Miyamoto N, Baba R, Umekawa T, Matsuda K, Sasaki T,
Nagamine Y, Umegaki K, Shirato H: “Realization of the Cone Beam CT by FPDs That Mounted
on the Spot-Scanning Dedicated Proton Beam Gantry.”, San Francisco (U.S.A.), ASTRO 56th
Annual meeting, 2014.9.14-17 [International conference](21) Katoh N, Onishi H, Matsushita H, Nomiya T, Nakata K, Shirato H: “Japanese Multiinstitutional Study of Stereotactic Body Radiation Therapy For Renal and Adrenal Tumors.”, San
Francisco (U.S.A.), ASTRO 56th Annual meeting, 2014.9.14-17 [International conference](22) Sutherland K, Kanehira T, Matsuura T, Umegaki K and Shirato H, “Geant4 Simulations of SpotScanned Proton Beam Treatment Plans”, Austin, AAPM 56th Annual Meeting & Exhibition, July
20-24 2014.7.20-14 [International conference](23) Wang J, Kato F, Kudo K, Yamashita H, Shirato H: “Predicting Triple-Negative Breast Cancer
and Axillary Lymph Node Metastasis using Diagnostic MRI.”, Gifu, IWDM 2014, 2014.6.29-7.2[International conference](24) Tha KK, Stehning C, Suzuki Y, Katscher U, Keupp J, Kazumata K, Terasaka S, Cauteren MV,
Kudo K, Shirato H: “Noninvasive Evaluation of Electrical Conductivity of the Normal Brain andBrain Tumors.” Milan (Italy), 22nd ISMRM, 2014.5.12-16 [International conference](25) Tha KK, Stehning C, Suzuki Y, Ulrich K, Jochen K, Kazumata K, Terasaka S, van Cauteren M,
Kudo K, Shirato H: “Noninvasive evaluation of electrical conductivity of the normal brain andbrain tumors.” Milan (Italy), The joint annual meeting ISMRM-ESMRMB, 2014.5.10-16[International conference](26) Kudo K, Liu T, Goodwin J, Uwano I, Yamashita F, Higuchi S, Fujima N, Wang Y, Ogasawara K,
Ogawa A, Sasaki M: “Oxygen Extraction Fraction Measurement using Quantitative Susceptibility
Mapping in Patients with Chronic Cerebral Ischemia: Comparison with Positron Emission
Tomography.”, Milan (Italy), ISMRM, 2014.5.12-16 [International conference]4) Patent applications
Number of patent applications (number of registered patents):
Japanese patents: 8 (8), overseas patents: 6 (5), total: 14 (13)(1) 2015-008434, Radiation therapy system and treatment program, 2015 January, Hokkaido Univ.,

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Shimizu S, Matsuura T, Takao S, Umegaki K, Katoh T et al.
(2) 2017-047982, Radiation therapy apparatus, 2017 March, Hokkaido Univ., Takao S, Matsuura T,
Umegaki K et al.
(3) 2014-245562, Radiation therapy system to control X-ray imaging intervals, 2014 December,
Hitachi Ltd. and Hokkaido Univ., Umegaki K et al.
(4) 2015-023202, Image processing unit and Particle beam therapy system equipped with image
processing unit, 2015 February, Hitachi Ltd. and Hokkaido Univ., Umegaki K, Takao S et al.
(5) 2016-32729, Particle beam therapy system and ridge filter, and method of manufacture of theridge filter, 2016 February, Hitachi Ltd. and Hokkaido Univ., Matsuura T, Umegaki K et al.
(6) 2016-69463, Particle Beam Dose Evaluation System, Planning Device, Particle Beam Irradiation
System, And Dose Evaluation Method, 2016 March, Hitachi Ltd. and Hokkaido Univ., Matsuura
T, Umegaki K, Shirato H et al.
(7) 2016-88163, Moving Body-Tracking Device And Radiation-Emitting System, 2016 April, Hitachi
Ltd. and Hokkaido Univ., Umegaki K et al.
(8) 2016-103596, Radiation Application System And Moving Body Tracking Apparatus, 2016 May,
Hitachi Ltd. and Hokkaido Univ., Umegaki K, Shimizu S et al.
(9) US 14/524,495 (Registered 2017), Charged particle beam system, 2014 October, Hitachi Ltd. andHokkaido Univ., Shirato H, Shimizu S, Umegaki K et al.
(10) PCT/JP2015/054184, Charged Particle Irradiation System, 2015 February, Hitachi Ltd. andHokkaido Univ., Shimizu S, Shirato H et al.
(11) PCT/JP2017/011866, Particle Beam Dose Evaluation System, Planning Device, Particle Beam
Irradiation System, And Dose Evaluation Method, 2017 March, Hitachi Ltd. and Hokkaido Univ.,
Matsuura T, Umegaki K, Shirato H et al.
(12) PCT/JP2017/013173, Moving Body-Tracking Device And Radiation-Emitting System, 2017
March, Hitachi Ltd. and Hokkaido Univ., Umegaki K et al.
(13) PCT/JP2017/015682, Tracking Object Recognition Simulator Or Marker Recognition Simulator,
Moving Body Tracking Device, And Irradiation System, 2017 April, Hitachi Ltd. and Hokkaido
Univ., Umegaki K et al.
(14) PCT/JP2017/017950, Radiation Application System And Moving Body Tracking Apparatus, 2017
November, Hitachi Ltd. and Hokkaido Univ., Umegaki K, Shimizu S et al.

,5) Awards, etc.
Number of awards: 11(1) Tha KK: “Guerbet Scientific Award, Third place” (Recent Advances and New Trends in Human
Glioma Imaging) AOCNR 2018, Taipei, 2018.3.18-20. *(2) Manabe N: “Certificate of Merit Award”, the Radiological Society of North America, November 30,
2017(3) Manabe N: “Award as identified for Radiographics”, Radiological Society of North America,
November 30, 2017
(4) Fujii Y, Umekawa T, Umezawa M, Shirato H, Umegaki K, Miyamoto N, Matsuura T: “Imperial
Invention Prize”, the 2017 National Invention *(5) Manabe N: “Best moderated Poster Award”, the 11th Congress of Asian society of cardiovascularimaging, June1-3, 2017(6) Koichi Yasuda: “Cypos Award, Bronze Medal”, the 76th Annual Meeting of the Japan RadiologicalSociety, Yokohama, April 13-16, 2017(7) Tha KK: 2016 Excellent teacher Award of the Hokkaido University Graduate School of Medicine(outstanding performance award)(8) Umegaki K: “Development and practical application of a Proton Beam Therapy System with 4-D
Real-time Tumor Tracking”, (The 13th Merit Award for Industry-Academia-government

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Collaboration, the Commendation for Science and Technology by the Minister of Education,
Culture, Sports, Science and Technology), 2015.8.28(9) Shirato H: Hokkaido University President's Award for Research Excellence for AY2014 (Excellent
Research Award), 2015.3.11(10) Shirato H: “Development and Clinical Research of a highly precise photon and particle beam
therapy using stereotactic irradiation and real-time tumor tracking technologies” (The 2014
Hokkaido Science and Engineering Award), 2015.2.20(11) Yasuda K: “[18F] fluoromisonidazole and a new PET system with semiconductor detectors and a
depth of interaction system for intensity modulated radiation therapy for nasopharyngeal
cancer.”, (The Umegaki award, 20th Japanese Society for Radiation Oncology (JASTRO)),2014.12.12
6) External grants
Number of awards: 5. Amount of the grant indicates direct cost only.
(1) Japan Agency for Medical Research and Development (AMED), “Research and development of
medical devices and systems to realize future medical care - Research and development project forminimally invasive cancer diagnostic equipment”, Development of next generation high precisionparticle beam therapy combining fine particle tumor markers with real-time 3-dimensional
fluoroscopy, 2015-2019, JPY213,378,183, Shirato H, Umigaki K, Shimizu S, Matuura T, Abo D,
Takao S, Sutherland KL, Nam JM, Katoh N, Inoue T et al.
(2) Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (Kakenhi),“Exploring target molecules to suppress changes in the extracellular microenvironment byradiation and invasive cancer recurrence”, 2016-2018, JPY3,600,000, Nam JM(3) Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (Kakenhi),
Young Scientists (A) “Development of a hybrid tomosynthesis and acoustic imaging modality forearly detection of breast cancer”, 2017-2019, JPY11,300,000, Peng H(4) Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (Kakenhi),
Young Scientists “To investigate the role of cancer stem cells in regulating the invasion ability ofradioresistant pancreatic cancer”, 2018-2020, JPY3,200,000, Hsieh, CC(5) Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (Kakenhi),
Young Scientists “Development of an acoustic imaging modality for absolute and real-time
radiotherapy dosimetry”, 2018-2019, JPY1,300,000, Wang J● Science outreach(1) Kudo K: “Visualizing cerebral diseases using magnetic forces and programming”, Lecture at
Otaru Chouryo High School, Otaru, February 8, 2018(2) Shirato H: “Present conditions and future prospects for medical physicist training”, Symposiumof Advanced Medical Professional Graduate School, Kyoto, February 2, 2018(3) Shirato H: “Accurate aiming at moving cancers”, The 26th Specially opened Innovative Scientific
University, Asahikawa, November 11, 2017(4) Shirato H: “Accurate aiming at moving cancers”, Lecture at High School, Asahikawa, November
10, 2017(5) Kudo K: “Visualizing cerebral diseases using magnetic forces and programming”, Lecture at
Sapporo Minami High School, Sapporo, October 26, 2017(6) Shirato H: “Hokkaido University leading the world in X-ray treatment and proton beam therapy
for cancer in moving organs”, 2017 Hokkaido Home Coming Day, Sapporo, September 30, 2017(7) Manabe N: “What does the body look like inside? Exploring the microcosm called the humanbody”, Minami High School, Rikka Seminar, Sapporo, September 30, 201698

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(8) Shimizu S: “Treatment of moving cancers” (the 3rd Chie lab lecture), Development of the proton
beam treatment device to treat moving cancers-a worldwide first, Chieria Citizen’s College,
Sapporo, September 17, 2016(9) Inoue T: “Radiation therapy for lung cancer”, “Advances in lung cancer treatment”, Public lecture
hosted by Hokkaido Newspaper, Sapporo Education and Culture Hall, June 18, 2016(10) Shirato H: “State-of-the-art cancer proton therapy”, The 29th Public Lecture by JapaneseCancer Association, Sapporo, May 14, 2017(11) Shimizu S: “Patient centered cancer treatment”, “Cancer treatment with minimal adverse
effects: radiation therapy and proton beam therapy”, Public lecture, Hokkaido University
Conference Hall, Sapporo, 2016.5.26(12) Shirato H: “The latest in cancer radiation therapy”, Advanced Medicine Promotion Organization,
TFT Hall at Tokyo Big Site, 2016.3.12(13) Shimizu S: “Integration of Spot-scanning technology into a Real-time tumor tracking system”,
Special lecture at the 938th Workshop Sapporo City General Hospital and Cancer Treatment
Center Network, Nov. 12, 2015.11.12(14) Shimizu S: “Introduction of the Hokkaido University Hospital Proton Beam Therapy Center,
Patient centered radiation therapy for cancer”, Public lecture by Hokkaido University Hospital
Proton Beam Therapy Center, Sapporo, Nov. 7, 2015.11.7(15) Shimizu S: “Delivering innovative medical care to you - Aiming at total care without surgery andminimal pain”, Lecture at The 9th Annual Hokkaido Meeting of the Nihon Sogo Igakukai(Japanese Society of General Medicine), Sapporo, 2015.9.27(16) Shirato H: “The present and future of proton beam therapy”, The 9th Specialist Seminar,
Hokkaido Branch of the Japanese Society of Gastroenterology Japanese GastroenterologicalEndoscopy Society, Sapporo Convention Center, Aug. 30, 2015.8.30(17) Shimizu S: “Aiming to deliver patient centered treatment with few adverse effects”, Open lecture
by Kyoto Prefectural University of Medicine, Kyoto, Jul. 22, 2015.7.22(18) Shirato H: Educational lecture “Features and perspectives of radiation therapy and particle
therapy”, The Japanese Society of Medical Oncology 2015 Annual Meeting, Royton Sapporo,2015.7.17(19) Shimizu S: “Proton Beam Therapy, Patient Advocate Program (PAP)”, The Japanese Society of
Medical Oncology 2015 Annual Meeting, Royton Sapporo, 2015.7.17(20) Shirato H: “Real-time Tumor Tracking Proton Beam Therapy System for Cancers”, Hokkaido
University Open Lecture (all-faculty project), 2015.7.2(21) Shimizu S: “Proton Beam Therapy, The 10th Tumor Center Seminar”, co-hosted by the
Department of Pharmacy and the Promotion Plan for the Platform of Human Resource
Development for Cancer team, Sapporo, 2015.2.19(22) Shimizu S: “Radiation therapy and proton beam therapy, Promotion Plan for the Platform of
Human Resource Development for Cancer”, Public lecture “Radiation therapy and proton beam
therapy – Aiming at cancer treatments with few adverse effects”, Public lecture for “Learning
about cancer treatment”, Sapporo, 2015.1.24(23) Umegaki K: “Small highly efficient proton beam therapy system”, Open lecture by Kyoto
Prefectural University of Medicine● Collaborations with institutions (universities, research institutes, local government, companies, etc.) other thanaffiliated universities
We have started international collaboration with other institutions to publicize GI-CoRE achievements.
Numerous researchers from internationally well-known institutions are collaborating in the GI-99

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CoRE Summer School for Medical Physics, the GI-CoRE Medical Science and Engineering Symposium,and the GI-CoRE seminars. Faculty members from the University of California San Francisco, theUniversity of California Los Angeles, the National Institute of Radiation Science (NIRS) in Chiba,
Tohoku University in Sendai, Osaka University in Osaka, the Nagoya Proton Therapy Center in
Nagoya, the Johns Hopkins University School of Medicine in Baltimore, the University Medical Center
Groningen in the Netherlands, the Mayo Clinic in Rochester, the University of Texas MD Anderson
Cancer Center in Houston, the University of Technology Sydney in Sydney, the University ofGroningen in the Netherlands, Peking University in Peking, and Pennsylvania University in
Philadelphia have contributed as lecturers in the Summer School for Medical Physics, in the GI-CoRE
Symposium, and in the GI-CoRE seminars in Sapporo.
The St. Jude Children’s Research Hospital, the Mayo Clinics in Rochester and Arizona, the MD
Anderson Cancer Center, the Johns Hopkins University, Kyoto Prefectural University, the National
Cancer Centre Singapore, and the University of Navarra, which have all introduced the proton beam
therapy system developed by HU and Hitachi, Ltd., visited HU and have promoted academic
collaborations with HU. For the research related to the particle beam therapy system jointly developed
by HU and Hitachi, Ltd. under the Funding Program for World-Leading Innovative R&D on Scienceand Technology (FIRST), the GSQ will conduct productive research with careful consideration of
intellectual property rights. For the collaboration with Shimadzu Corporation, it is also planned to
improve the SyncTraX function of the real-time tumor tracking device for X-ray therapy. AISIN/IMRA
America and GI-CoRE GSQ collaborated to perform the research project on RGD-peptide-conjugatedgold nanoparticles for radiation sensitization and presented the research at international andJapanese conferences, and have published in the International Journal of Nanomedicine (2017).
An Associate Executive Director of the American Board of Radiology attended the GSQ meeting aspart of the preparations for our summer school - to make an educational course that meets therequirement for accreditation of medical physicists in the U.S.
Researchers from Asian and European universities and cancer institutions are also interested in the
proton beam therapy center at HU. Prof. Shirato was nominated as a member of Proton Advisory
Board of the National Cancer Centre Singapore. As of March 2018, there have been more than 2,400
visitors to see the proton beam therapy center and about twenty percent of the visitors are fromoverseas.
● Issues affecting the research and measures to overcome these/future developments
One of the elements of our potential improvement for the further enhancement of the GI-CoRE wasto send young researchers into eminent institutions. In this regard, we have sent young scientists todistinguished science institutions: Drs. Abo and Yasuda visited SU for a collaborative research. Dr. Wu,
a graduate student, also visited the SU lab. Mr. Kwon, a graduate student, and Dr. Kikuchi, a postdoctoral researcher, are on a one-year visit to Harvard University. Dr. Kanehira, a graduate of HU, iscurrently a post-doctoral researcher at the Netherlands Institute for Cancer. We hope the GI-CoRE
will benefit from what those renowned institutions could offer to young researchers.

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A

2. Education (Graduate Schools to Foster Global Human Resources)(1) Goals
Based on the research outcomes at the GSQ, HU opened a “Graduate School of Biomedical Scienceand Engineering” in April, 2017.
The Graduate School of Biomedical Science and Engineering features a new disciplinary direction
integrating the biomedical science and engineering fields, aiming to apply developments in science andengineering to medical science, under the four basic principles adhered to by Hokkaido University:
Frontier Spirit, Global Perspectives, All-round Education, and Practical Learning.
In this graduate school, teaching staff of the Faculty of Science, the Faculty of Health Sciences, theFaculty of Engineering, the Faculty of Medicine, and the Faculty of Dental Medicine have been
participating in the education of specialists who will be able to contribute their knowledge of quantum
science and engineering as well as molecular science and engineering to medicine. The Graduate
School of Biomedical Science and Engineering also aims to ensure that students attain a basic
knowledge of medical fields and a thorough in-depth knowledge of science and engineeringtranscending the limits of conventional study areas, and which will enable the graduated specialists
to be equipped with the highest ethical and humanitarian qualities.
Furthermore, it also aims to conduct studies to develop medical equipment to meet the needs ofbusiness and industry while promoting research related to medical physics for academia in our mission
to meet the various needs of society. It is also expected that these efforts will make a significant
contribution to the development of medical equipment, establishment of economic advantages inmedical technology, improving competitiveness, and assisting in the creation of new important
industries and other ventures.
(2) Current Progress/Future Developments① Operating System of Education / Organizational Structure of Educational Programs● Overview, background and social needs
The Graduate School of Biomedical Science and Engineering set up Biomedical Science andEngineering Courses (a Quantum Biomedical Science and Engineering Course and a Molecular
Biomedical Science and Engineering Course), incorporated in a two-year Master’s Program and athree-year Doctoral Program. The graduate school confers Master’s (in biomedical science andengineering) and Doctoral degrees (Ph.D.) to graduating students. In the Master’s program, thegraduate school trains experts who will contribute to society through medical physics and equipment
development work related to radiology, with a thorough understanding of medical ethics. In the
Doctoral program, the graduate school will train outstanding specialists who will be able to playleading roles in international research with knowledge and skills that will enable them to become
leaders in these areas.
The Graduate School of Biomedical Science and Engineering is determined to respect the diverse
backgrounds of students, and to offer a unique curriculum with lectures integrating medicine, scienceand engineering. English education will also be provided through the collaboration of the faculty of
medical engineering and medicine exclusive to this new school where several instructors will provide
each student with instruction related to the research.
The researchers who are joining the GSQ are expected to be teachers in the Graduate School of
Biomedical Science and Engineering. The researchers who are hired in HU as well as the researchersvisiting from SU have been providing lectures for graduate students and supervised research of
doctoral students. Faculty of Radiation Oncology (three professors, one associate professor, and two
assistant professors), Radiation Biology (one professor, one assistant professor, and one research
fellow), and Medical Physics (one professor, one associate professor, and one assistant professor) of SU
have stayed at HU for a total of several months every year to provide lectures, conduct research, and101

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make arrangements for international clinical joint research. Furthermore, one or two assistantprofessors and senior assistant professors of SU have spent time at HU every year to engage in
research and instruction at the undergraduate and graduate schools here. Supported by an excellent
environment for research and education, joint research and specialist training in the quantum
medical science and engineering fields are promoted, based on the established GSQ. These meet theobjectives of the GI-CoRE forming the foundations of a strong and flexible research framework andsupport arrangements.
In recent years, active involvement in health promotion and medical care is expected of educationaland research institutions in Japan. This involvement should contribute to the realization of a healthysociety, extended longevity, economic growth and global development. Society has a need for talented
scientists who are able to apply innovative technology from science and engineering to assist in
alleviating patient suffering brought about by diseases, through an understanding of the physiology ofthe human body and the pathology of diseases. The Graduate School of Biomedical Science andEngineering was established with the aim to train specialists who will be able to make suchcontributions.
In the Quantum Biomedical Science Course,
it is also planned to train specialists who will
become engaged in the development of medical
technology
andequipment(medicalapplications) for use in radiation treatment,
medical physics research and development ofqualitycontrol
techniques,
andtheoptimization of radiation treatment plans aswell as evaluation of treatment accuracy as
medical physicists. The students will becomprehensively trained to become specialists
inradiation treatment capable to conduct
Fig. 15 Structure of Graduate School of Biomedical Scienceand Engineering, Hokkaido University
advanced radiation treatment safely andefficiently in concert with physicians andmedical professionals (clinical radiological technologists, radiotherapy quality control specialists, anddosimetrists).
In the Molecular Biomedical Science and Engineering Course students will be trained as specialists
equipped with specialized knowledge and skills in quality control and verification of diagnostic images.
After graduation, these specialists are expected to apply science and engineering technology inresearch and development related to new molecular imaging devices for use with in vivo molecules indiagnosis, as well as related molecular diagnostics, oncolytic virotherapy, and radiation sensitizers. In
short, students will learn how to integrate molecular targeted therapies with imaging and radiation
therapy, while maintaining a clear balance between effectiveness and safety of diagnoses as is expectedfrom physicists in clinical settings. In both courses, all of the graduate school faculty systematicallyprovide an innovative integrated education in basic knowledge and skills in the fields of science andengineering as well as a basic education in medicine and medical ethnics.

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② International Collaborative Education● Operating system of Education

Fig. 16 Approach and Steps to the Entrance Examination and Screening Test (Master’s/Doctoral Programs)

Admission numbers is twelve to the Master’s Program and five to the Doctoral program, It is
expected that the Master’s Program will admit students from the faculties of medicine (health sciences),
engineering, and science, while the Doctoral Program will admit students from graduate schools inbioscience and engineering areas as well as graduates of dental medicine. Last year, there were 16
masters students and 9 doctoral students enrolled.
● Good practices at the graduate school
The GSQ has held international symposia five times, and the number of participants is increasing
annually. The latest GI-CoRE GSQ, GSB, & IGM Joint Symposium was successfully held over two daysin July 2017, with four lecturers from SU, two lecturers from the University of Technology, Sydney,
one lecturer from the National Institute for Quantum and Radiological Science and Technology, andone lecturer from Osaka University as well as lecturers from HU. (Fig. 17). In parallel with thesymposium, a lecturer from SU also gave lectures on radiation biology for graduate students. (Fig. 18)
The symposium was attended by 250 participants, which is a good indication that the efforts of the
GSQ to expand the education and research area has progressed satisfactorily.

Fig.17

Speakers and participants at the GI-CoRE
GSQ, GSB, & IGM Joint Symposium

Fig.18 Lecture for graduate students by Prof. Giaccia

The GSQ has also held the GI-CoRE Summer School for Medical Physics four times with faculty of
SU. This is a one-week program and all the lectures and training in medical physics have been

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conducted in English. To date, the Summer Schools have had a total of 83 participants from 26
countries. (Fig. 19)
The GSQ will hold the 5th GI-CoRE Summer School for Medical Physics and the 1st GI-CoRE Summer
School for Radiation Biology in August of this year. Both Summer Schools are jointly conducted with
the Hokkaido Summer Institute 2018-Medical Physics School- and the Hokkaido Summer Institute2018-Radiation Biology School. The Hokkaido Summer Institute enables the participants to earncredits as graduate school study, which was suggested in the interim appraisal. The GSQ started
accepting applications for the Hokkaido Summer Institute and the Summer Schools in February, 2018.

Fig.19Participants and lecturers at the 4th GI-CoRE Summer School for Medical Physics● Future developments(1) To strengthen English education by increasing the number of faculty and providing lectures
exclusive to the Graduate School of Biomedical Science and Engineering, and to improve thequality of the GI-CoRE Summer School for Medical Physics and for Radiation Biology/the
Hokkaido Summer Institute.
(2) To have a curriculum that meets the requirements for accreditation of medical physicists in theU.S, and to increase the percentage of international admissions.
(3) To increase the number of international joint studies by developing further relationships withfaculty of institutions other than the Department of Radiation Oncology of Stanford University.
Overall, there will be numerous opportunities for graduate students and young researchers toexperience innovative research at sophisticated leading laboratories, with education and instruction
provided by internationally leading researchers, and through these, participants will gain a global
perspective and know-how. This direct experience will stimulate the young researchers and students,
leading to the development of dynamic youthful researchers, faculty, and other staff.

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3. Establishment of Framework(1) Management System
The Global Institution for Collaborative Research and Education (GI-CoRE) was established in April
2014 as a faculty organization under the direct control of the Hokkaido University President, with theaim of promoting international collaborative research and education that leverages Hokkaido
University’s strengths and distinctive character. The GI-CoRE is positioned as an independent
educational and research organization managed by the President as its director. It brings together
world-class teaching staff from around the world, within Japan and within Hokkaido University (HU),
based on a new idea to invite the world’s highest level research units. GI-CoRE’s framework enables
the conducting of international collaborative research and education systematically together withleading research units invited from the overseas, rather than relying on international exchange
promoted by researchers individually. Implementing this unprecedented way to welcome overseas
researchers, HU reformed the management system and established the framework of GI-CoRE
effectively under the President’s powerful leadership. GI-CoRE appointed the President as the director,
and Vice President for International Affairs as the deputy director. Under the President/GI-CoRE
director, the GI-CoRE steering committee is established to discuss matters important to GI-CoRE andcomprises the President, Vice Presidents for International Affairs and for Planning and Management,
and faculty deans/research center directors who are appointed to serve as members to the committee
in turn. The steering committee was held in total 14 times by March 2018, and discussed 1) Mattersregarding personnel transfers of faculties, 2) Matters regarding the establishment, reform or
termination of global stations, 3) Matters regarding the evaluation of the research and educational
activities of global stations, 4) Matters regarding budgets, and 5) Other important matters pertaining
to the administration of GI-CoRE such as progress reports. To promote the collaborative researchand education that capitalizes upon the distinctive characteristics of the university practically, HU
places global stations (GS) in GI-CoRE. Each GS has a designated station director who shall be oneof the core teaching staff in the research field. Invited world-leading overseas research units are
assigned to the GS so as to foster them in promotion of international collaborative research andeducation together with the leading teaching staff within the university.
＜Member List of the Steering Committee＞
Name*As of 1 April 2018

Affiliation 1

Affiliation 2
Director, Global Institution for1

Toyoharu NAWA

President

Collaborative Research and
Education

2
3
4

Masanori
KASAHARA

Deputy Director, Global
Executive / Vice President

Research and Education

Jyunji NISHII

Executive / Vice President

Fumihiko

Dean / Professor, Graduate

YAMAMOTO

5

Koichiro ISHIMORI

6

Takeshi SAITO

Institution for Collaborative

School of Letters
Dean / Professor, Faculty of
Science
Dean / Professor, Faculty of
Health Sciences

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Toshiyuki

Director / Professor, Research

NAKAGAKI

Institute for Electronic Science8

Hiroki SHIRATO

Professor, Faculty of Medicine

9

Hirofumi SAWA

10

Takashi INOUE

11

Jian Ping GONG

7

12

13

Yoshikazu
MIYANAGA

Professor, Research Center for
Zoonosis Control
Professor, Research Faculty ofAgriculture
Professor, Faculty of Advanced
Life Science
Professor, Graduate School ofInformation Science andTechnology

Natsuhiko

Professor, Arctic Research

OTSUKA

Center

14

Ko HASEGAWA

15

Ryuichiro SHIMA

Director, Global Station for
Quantum Medical Science andEngineering
Director, Global Station for
Zoonosis Control
Director, Global Station for Food,Land and Water Resources
Director, Global Station for Soft
MatterDirector, Global Station for Big
Data and Cybersecurity
Director, Global Station for
Arctic Research

Executive / Vice President
Director, International Affairs
Department(2) Establishment, Improvement of Acceptance System/Environment, Future Vision, Etc.
Under the governance of the President, GI-CoRE has established the necessary system to accept
overseas researchers and improved the environment to operate GI-CoRE tasks as the following, inorder to invite the world’s top research units from external universities and institutions, as well as
allow them to collaborate with the fine teaching staff in the related disciplines of the university.
1. GI-CoRE introduced the cross appointment system with overseas universities andinstitutions before the system implementation by the whole university. The crossappointment system is to appoint top-class researchers from overseas and domestic
institutions at Hokkaido University, while keeping their status at the host institutions andpay salaries to them based on the level of the effort at Hokkaido University.
2. The implementation of cross appointment system has produced more flexible personnel andsalary system for the overseas faculty members such as choosing the annual salary system,
relaxing the employment age restriction, and establishing a new title Distinguished
Professor which shall be awarded in recognition of particularly important achievement intheir fields of study.
3. For the overseas researchers who conduct education and research activities at Hokkaido
University, GI-CoRE has set up a flexible system on travel expense and accommodation
rental.
4. To utilize the exiting research resources in the university, GI-CoRE has also applied thecross appointment system to the participating researchers of Hokkaido University who
conduct international collaborative research and education, and appointed them to thepositions both in their original departments and in GI-CoRE.
5. Upon conducting advanced international collaborative research and education, GI-CoRE hasreviewed the point-based personnel system and applied flexible personnel distribution even106

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in positions for researchers.
6. To secure the academic environment to concentrate on research, GI-CoRE faculty members
are exempt from administrative tasks such as faculty meetings, etc.
The above-mentioned cross appointment system, annual-salary system for regular teaching staff, andother relevant systems have been started as a pilot system for other departments within the university.
Other than these systems, GI-CoRE has also provided rich research environments and extensive
educational experiences to young researchers, as well as led good effects as fusion of different research
fields/interdisciplinary collaboration with diversified departments to cooperate in the project.
Given the proven cycle, effectiveness of the pilot systems at GI-CoRE has been gradually expanded
to the whole university and has started to reinforce the university’s administrative function.
Even now, GI-CoRE utilizes the established network and achieved outcomes of collaborative
research with institutions/organizations in order to further strengthen research projects which givethe entire university a certain advantage over other research universities and implements ‘global
postgraduate-level education by organic fusion of different fields’ at graduate schools of related fields.
For this promotion, besides the management expenses granted by the Japanese government, GI-CoRE
aims to obtain various funds such as competitive funds as grants-in-aid for scientific research anddonation, etc.
(3) Administrative System
In order to support research and educational activities in each global station, administrative staff
are required to strengthen their capabilities to handle international affairs. Considering this,Hokkaido University has set up a GI-CoRE-specialized administrative section in the International
Affairs Department, distributed staff members with study/work abroad experiences to the section, andestablished bilingual (English) administrative support systems. Also, bilingual staff have beenstationed in each global station office to support daily research activities conducted there.

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IV. Supplemental Revision● Research results (FY 2018-2019)
As of March 2020
1. International collaborative

Featured in Japanese journals: 0, featured in overseas journals: 21

papers (peer reviewed)
2. Other publications

Featured in Japanese journals: 4, featured in overseas journals: 61,
books published: 1

3. Verbal presentations

Keynote speeches:16, invited lectures:47 (Japanese 34, International
13)
other presentations: 123 (Japanese 54, International 69)

4. Patent applications

Registered patents: 0 (0 in Japan, 0 overseas)
Pending patents: 16 (9 in Japan, 7 overseas)

5. Awards received

12

6. External grants

21) International collaborative papers (peer reviewed)- Journals published by Japanese publishers, including those published in English, are listed as "Japanese journals".
- Papers where "GI-CoRE" is stated as an affiliated institution of a Japanese or overseas researcher, or thosementioning "Hokkaido University " in the acknowledgements, are marked with a "* (asterisk)" and the applicable
author name is underlined.
- Among the papers with "* (asterisk)", papers where "GI-CoRE" is stated as an affiliated institution are marked
with "i)", and papers which mention "Hokkaido University" in the acknowledgements are marked with "ii)".
- Papers where GI-CoRE researchers of Hokkaido University and Stanford University are stated are marked with"○".
(1) Jihun Kwon, Rajalekha M. Rajamahendiran, Needa A. Virani, Sijumon Kunjachan, Erin Snay,
Max Harlacher, Marios Myronakis, Shinichi Shimizu, Hiroki Shirato, Tomasz J. Czernuszewicz,
Ryan Gessner, Ross Berbeco. Use of 3D contrast-enhanced ultrasound to evaluate tumor
microvasculature after nanoparticle-mediated modulation. Ultrasound in Medicine & Biology, inpress [Overseas journal] *, i)(2) Yusuke Nomura, Qiong Xu, Hao Peng, Seishin Takao, Shinichi Shimizu, Lei Xing and Hiroki
Shirato. Modified fast adaptive scatter kernel superposition (mfASKS) correction and its
dosimetric impact on CBCT-based proton therapy dose calculation,in press Med Phys. [Overseas
journal] *, i), ii) ○(3) Yusuke Nomura, Jeff Wang, Hiroki Shirato, Shinichi Shimizu and Lei Xing. Fast spot-scanning
proton dose calculation method using a three-dimensional convolutional neural network. In
press, Physics in Medicine and Biology. [Overseas journal] *, i), ii) ○(4) Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato
H Predicting Metastasis in Clinically Negative Axillary Lymph Nodes with Minimum Apparent
Diffusion Coefficient Value in Luminal A-like Breast Cancer. Breast Cancer. 2019 Sep;26(5):628636. [Overseas journal] *, i), ii), ○(5) Takayanagi, Taisuke & Uesaka, Tomoki & Kitaoka, Masanori & Unlu, Mehmet & Umegaki,

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Kikuo & Shirato, Hiroki & Xing, Lei & Matsuura, Taeko. A novel range-verification method using
ionoacoustic wave generated from spherical gold markers for particle-beam therapy: asimulation study (2019) Scientific Reports. 2019 Mar 8;9(1):4011. doi:. 10.1038/s41598-01938889-w. [Overseas journal] *, i), ii), ○(6) Wu PH, Onodera Y, Recuenco FC, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM. LambdaCarrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing
Cancer Cell Invasion and Metastasis through Racgap1 Inhibition. Cancers (Basel). 2019 Aug
16;11(8). pii: E1192. doi: 10.3390/cancers11081192. [Overseas journal] *, i), ii), ○(7) Yusuke Nomura, Qiong Xu, Hiroki Shirato, Shinichi Shimizu, Lei Xing, Projection-domain
scatter correction for cone beam computed tomography using a residual convolutional neuralnetwork. (Received 12 December 2018; revised 8 April 2019; accepted for publication 24 April
2019; Medical Physics, in press, 2019 *, i), ○(8) C Liu, Z Li, W Hu, L Xing, H Peng Range and dose verification in proton therapy using protoninduced positron emitters and recurrent nenuralnetworks (RNNs) - Physics in Medicine &Biology, 2019 - iopscience.iop.org [Overseas journal] *, i)(9) Z Li, Y Wang, Y Yu, K Fan, L Xing, H Peng Machine Learning Approaches for Range and Dose
Verification in Proton Therapy Using Proton-induced Positron Emitters - Medical physics, 2019
- Wiley Online Library [Overseas journal] *, i)(10) Y Yu, Z Li, D Zhang, L Xing, H Peng Simulation Studies of time reversal- based photoacoustic
reconstruction for range and dose verification in proton therapy - Medical physics, 2019 - Wiley
Online Library [Overseas journal] *, i)(11) Demirkan, Irem, Mehmet Burcin Unlu, and Bukem Bilen. Determining sodium diffusion
through acoustic impedance measurements using 80 MHz Scanning Acoustic Microscopy:
Agarose phantom verification. Ultrasonics 94 (2019): 10-19. [Overseas journal] *(12) Fujima N, Hirata K, Shiga T, Li R, Yasuda K, Onimaru R, Tsuchiya K, Kano S, Mizumachi T,
Homma A, Kudo K, Shirato H. Integrating quantitative morphological and intratumoural
textural characteristics in FDG-PET for the prediction of prognosis in pharynx squamous cell
carcinoma patients. Clinical Radiology 2018 Sep 21; 73 (12): 1059.e1–1059.e8, [Epub ahead ofprint] [Overseas journal] *, i),○(13) Prayongrat A, Kobashi K, Ito Y M, Katoh N, Tamura M, Dekura Y, Toramatsu C, Khorprasert C,
Amornwichet N, Alisanant P, Shirato H, Shimizu S. The normal tissue complication probability
model-based approach considering uncertainties for the selective use of radiation modality inprimary liver cancer patients. Radiotherapy and Oncology 135 (2019) 100-106 [Overseas journal]i)(14) Fujima N, Homma A, Harada T, Shimizu Y, Tha KK, Kano S, Mizumachi T, Li R, Kudo K, Shirato
H. The utility of MRI histogram and texture analysis for the prediction of histological diagnosis
in head and neck malignancies. Cancer Imaging 2019 Feb 4;19(1):5. doi: 10.1186/s40644-0190193-9. [Overseas journal] *, i),○(15) Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato
H. Predicting metastasis in clinically negative axillary lymphnodes with minimum apparent
diffusion coefficient value in luminal A-like breast cancer. Breast Cancer. 2019 doi:
10.1007/s12282-019-00969-0. [Overseas journal] *, i),ii), ○(16) Kwon J, Sutherland K, Makarova A, Matsuura T, Hashimoto T, Peng H, Toshito T, Umegaki K,
Shirato H, Shimizu S Investigation of energy absorption by clustered gold nanoparticles. Nuclear
Instruments and Methods in Physics Research Section B: Beam Interactions with Materials andAtoms, 429, 34-41. 2018 [Overseas journal] ○(17) Takayanagi T, Uesaka T, Kataoka M, Unlu MB, Umegaki K, Shirato H, Xing L, Matsuura T, “A
novel range verification method using ion-acoustic wave generated from spherical gold markers
for particle beam therapy: a simulation study”, in revision, Scientific Reports (2018). [Overseas
2109

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journal] ○(18) Nishikawa Y, Yasuda K, Okamoto S, Ito Y M, Onimaru R, Stiga T, Tsuchiya K, Watanabe S,
Takeuchi W, Kuge Y, Peng H, Tamaki N, Shirato H. Local relapse of nasopharyngeal cancer andVoxel-based analysis of FMISO uptake using PET with semiconductor detectors. Radiat Oncol.
2017 Sep 6;12(1):148. doi: 10.1186/s13014-017-0886-9 [Overseas journal] *, i) ○(19) Bilen, Bukem, Belkis Gokbulut, Ulku Kafa, Emre Heves, Mehmet Naci Inci, and Mehmet Burcin
Unlu. "Scanning Acoustic Microscopy and Time-Resolved Fluorescence Spectroscopy for
Characterization of Atherosclerotic Plaques." Scientific Reports 8, no. 1 (2018): 14378. [Overseas
journal] *, i)(20) Uluc, Nasire, Mehmet Burcin Unlu, Gultekin Gulsen, and Hakan Erkol. "Extended
photoacoustic transport model for characterization of red blood cell morphology in microchannel
flow." Biomedical Optics Express 9, no. 6 (2018): 2785-2809. [Overseas journal] *, i)(21) Demirkan, Irem, Mehmet Burcin Unlu, and Bukem Bilen. "Determining Sodium Diffusion
through Acoustic Impedance Measurements using 80 MHz Scanning Acoustic Microscopy:
Agarose Phantom Verification." Ultrasonics (2018). [Overseas journal] *, i)2) Other original papers- major papers only.
Japanese journals (including those in English)(1) Mizumachi T, Kano S, Homma A, Akazawa M, Hasegawa C, Shiroishi Y, Okamoto C,Kumagai S,
Nishimura M, Takasaki H, Takeda H, Yasuda K, Minatogawa H, Dekura Y,Onimaru R, Shirato H,
Fukuda S. [A Nutritional Supplement with a High Blend Ratio of ω-3 Fatty Acids(Prosure®)
Reduces Severe Oral Mucositis and Body Weight Loss for Head and Neck Cancer Patients Treatedwith Chemoradiotherapy]. Gan To Kagaku Ryoho. 2019 Apr;46(4):685-689. Japanese. PubMed
PMID: 31164507. [Japanese journal] *(2) Takayuki Hashimoto, Shinichi Shimizu,Seishin Takao,Shunsuke Terasaka, Akihiro Iguchi,
Hiroyuki Kobayashi, Takashi Mori,Takaaki Yoshimura, Yuto Matsuo, Masaya Tamura, Taeko
Matsuura, Yoichi M. Ito, Rikiya Onimaru and Hiroki Shirato , Clinical experience of craniospinal
intensity modulated spot-scanning proton therapy using large fields for central nervous systemmedulloblastomas and germ cell tumors in children, adolescents, and young adults. Journal of
Radiation Research, Vol. 60, No. 4, 2019, pp. 527–537doi: 10.1093/jrr/ rrz022 Advance AccessPublication: 21 May 2019 [Japanese journal] *, i)(3) Onimaru R, Onishi H, Ogawa G, Hiraoka M, Ishikura S, Karasawa K, Matsuo Y, Kokubo M,
Shioyama Y, Matsushita H, Ito Y, Shirato H. Final report of survival and late toxicities in the
Phase I study of stereotactic body radiation therapy for peripheral T2N0M0 non-small cell lungcancer (JCOG0702). Jpn J Clin Oncol. 2018 Oct 1. doi: 10.1093/jjco/hyy141. [Japanese journal](4) Morita R, Abo D, Soyama T, Sakuhara Y, Kajiyama M, Kudo K. Spontaneous recovery of multiple
hepatic artery aneurysms with segmental arterial mediolysis. Interventional Radiology 2018 In
press [Japanese journal]
Overseas journals(1) Miyamoto N, Maeda K, Abo D, Morita R, Takao S, Matsuura T, Katoh N, Umegaki K,Shimizu S, Shirato H.
Quantitative evaluation of image recognition performance of fiducial markers in real-time tumor-tracking
radiation therapy. Phys Med. 2019 Sep;65:33-39. doi: 10.1016/j.ejmp.2019.08.004. Epub 2019 Aug 12. PubMed
PMID:31430584. [Overseas journal] *, i), ii)(2) Uchinami Y, Suzuki R, Katoh N, Taguchi H, Yasuda K, Miyamoto N, Ito YM, Shimizu S, Shirato H. Impact oforgan motion on volumetric and dosimetric parameters in stomach lymphomas treated with intensity-modulated
radiotherapy. J Appl Clin Med Phys. 2019 Aug;20(8):78-86. doi: 10.1002/acm2.12681. Epub 2019 Aug 10.
3
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PubMed PMID: 31400082; PubMed Central PMCID: PMC6698764. [Overseas journal] *, i), ii)(3) Ishikawa H, Tsuji H, Murayama S, Sugimoto M, Shinohara N, Maruyama S, Murakami M, Shirato H, Sakurai
H. Particle therapy for prostate cancer: The past, present and future. Int J Urol. 2019 Oct;26(10):971-979. doi:
10.1111/iju.14041. Epub 2019 Jul 8. Review. PubMed PMID: 31284326. [Overseas journal] *, i)(4) Endo K, Takahata M, Sugimori H, Yamada S, Tadano S, Wang J, Todoh M, Ito YM, Takahashi D, Kudo K,
Iwasaki N. Magnetic resonance imaging T1 and T2 mapping provide complementary information on the bonemineral density regarding cancellous bone strength in the femoral head of postmenopausal women withosteoarthritis.Clin Biomech (Bristol, Avon). 2019 May;65:13-18. doi: 10.1016/ j.clinbiomech.2019.03.010.
Epub 2019 Mar 20. [Overseas journal] *(5) Morita R1 Abo D, Sakuhara Y, Soyama T, Katoh N, Miyamoto N, Uchinami Y, Shimizu S, Shirato H, Kudo K
Percutaneous insertion of hepatic fiducial true-spherical markers for real-time adaptive radiotherapy. Minim
Invasive Ther Allied Technol. 2019 Sep 13:1-10. [Overseas journal] *, i), ii)(6) Oyama-Manabe N, Manabe O, Naya M, Kudo K, Tamaki N. Comprehensive evaluation of myocardial ischemia
with dynamic perfusion CT. Annals of Nuclear Cardiology 2019; 5(1) 79-83 [Overseas journal] *(7) Abe N, Kato M, Fujieda Y, Narita H, Tha KK, Atsumi T. Tumor necrosis factor alpha blockade for noninflammatory pain: beyond inflammation? Scand J Rheumatol. 48(6): 519-521, 2019 May 28:1-3. [Overseas
journal] *(8) Kazumata K, Tha KK, Tokairin K, Ito M, Uchino H, Kawabori M, Sugiyama T. Brain Structure, Connectivity,
and Cognitive Changes Following Revascularization Surgery in Adult Moyamoya Disease. Neurosurgery. 2019
Jun 3. pii: nyz176. doi: 10.1093/neuros/nyz176. [Overseas journal] *(9) Kato K, Yasojima N, Tamura K, Ichikawa S, Sutherland K, Kato M, Fukae J, Tanimura K, Tanaka Y, Okino T,
Lu Y, Kamishima T. Detection of Fine Radiographic Progression in Finger Joint Space Narrowing Beyond
Human Eyes: Phantom Experiment and Clinical Study with Rheumatoid Arthritis Patients. Sci Rep. 2019 Jun
12;9(1):8526. doi: 10.1038/s41598-019-44747-6. PMID: 31189913 [Overseas journal] *(10) Fujimori M, Kamishima T, Narita A, Henmi M, Kato M, Sutherland K, Nishida M, Tanaka Y, Yutong L,
Tanimura K, Atsumi T. Quantitative power Doppler signal assessment in the subchondral bone region of themetacarpophalangeal joint is an effective predictor of radiographic progression in the hand of rheumatoid
arthritis: a pilot study. Rheumatol Int. 2019 Aug;39(8):1413-1421. doi: 10.1007/s00296-019-04320-w. Epub
2019 May 14. PMID: 31089859 [Overseas journal] *, i)(11) Fujimori M, Murakami K, Sugimori H, Lu Y, Sutherland K, Oki N, Aoki T, Kamishima T. Intravoxel incoherent
motion MRI for discrimination of synovial proliferation in the hand arthritis: A prospective proof-of-concept
study. J Magn Reson Imaging. 2019 Oct;50(4):1199-1206. doi: 10.1002/jmri.26660. Epub 2019 Jan 31 PMID:
30706568 [Overseas journal] *, i)(12) Kenneth Sutherland1. Toshiyuki Hamada2 . Masayori Ishikawa 1A. Naoki Miyamoto 1 ·5 . Masahiro Mizuta3 .
Hiroyuki Date4 . Hiroki Shirato 1 ,5 3D Transformation Matrix Calculation and Pixel Intensity Normalization
for the Dual Focus Tracking System. Journal of Medical and Biological Engineering August 2019https://doi.org/10.1007/s40846 019-00474-x [Overseas journal] *, i), ii)(13) Shimizu Y, Kudo K, Kameda H, Harada T, Fujima N, Toyonaga T, Tha KK, Shirato H. Prediction of Hypoxia
in Brain Tumors Using a Multivariate Model Built from MR Imaging and (18)F-Fluorodeoxyglucose
Accumulation Data. Magn Reson Med Sci. 2019 Oct 15. doi: 10.2463/mrms.mp.2019-0049. [Epub ahead ofprint] PubMed PMID: 31611541. [Overseas journal] *, i)(14) Furuya S, Naya M, Manabe O, Hirata K, Ohira H, Aikawa T, Koyanagawa K, Magota K, Tsujino I, Anzai T,
Kuge Y, Oyama-Manabe N, Kudo K, Shiga T, Tamaki N. 18 F-FMISO PET/CT detects hypoxic lesions of cardiac
and extra-cardiac involvement in patients with sarcoidosis.J Nucl Cardiol 2019 Dec 9. doi: 10.1007/s12350019-01976-6. [Epub ahead of print] [Overseas journal] *, ii)(15) Kobayashi K, Manabe O, Hirata K, Yamaguchi S, Kobayashi H, Terasaka S, Toyonaga T, Furuya S, Magota K,
Kuge Y, Kudo K, Shiga T, Tamaki N. Influence of the scan time point when assessing hypoxia in 18 Ffluoromisonidazole PET: 2 vs. 4 h.Eur J Nucl Med Mol Imaging. 2019 Nov 28. doi: 10.1007/s00259-01904626-8. [Epub ahead of print] [Overseas journal] *, i)4111

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(16) Tha KK Cognitive Impairment, Neuroinflammation, and MRI. Journal of Magnetic Resonance Imaging
manuscript number JMRI-19-1437) [accepted] [Overseas journal] *, i)(17) Ueno, Koki & Matsuura, Taeko & Hirayama, Shusuke & Takao, Seishin & Ueda, Hideaki & Matsuo, Yuto &Yoshimura, Takaaki & Umegaki, Kikuo. Physical and biological impacts of collimator-scattered protons inspot-scanning proton therapy (2019). Journal of Applied Clinical Medical Physics. 20. 10.1002/acm2.12653.
[Overseas journal] *, i), ii)(18) Naoki Miyamoto, Kouhei Yokokawa, Seishin Takao, Taeko Matsuura, Sodai Tanaka, Shinichi Shimizu, Hiroki
Shirato, Kikuo Umegaki. Dynamic gating window technique for the reduction of dosimetric error in respiratorygated spot-scanning particle therapy: an initial phantom study using patient tumor trajectory data (2020).
Journal of Applied Clinical Medical Physics. Accepted [Overseas journal] *, i)(19) Shusuke Hirayama, Taeko Matsuura, Koichi Yasuda, Seishin Takao, Takaaki Fujii, Naoki Miyamoto, Kikuo
Umegaki, and Shinichi Shimizu, Difference in LET-based biological doses between IMPT optimization
techniques: robust and PTV-based optimizations (2020) Journal of Applied Clinical Medical Physics. Accepted[Overseas journal] *, i), ii)(20) Yokokawa, K, Furusaka, M, Matsuura, T, Hirayama, S, Umegaki, K, A new SOBP-formation method bysuperposing specially shaped Bragg curves formed by a mini-ridge filter for spot scanning in proton beam
therapy, Physica medica, November 2019; 67, 70-762019-11, ISSN: 1120-1797 [Overseas journal] *, i)(21) Hirayama S, Matsuura T, Yasuda K, Takao S, Fujii T, Miyamoto N, Umegaki K, Shimizu S, Difference in LETbased biological doses between IMPT optimization techniques: Robust and PTV-based optimizations. (2020)
Journal of Applied Clinical Medical Physics. 2020 Mar 9. doi: 10.1002/acm2.12844 [Overseas journal] *, i),ii)(22) Hashimoto S, Furukawa S, Hashimoto A, Tsutaho A, Fukao A, Sakamura Y, Parajuli G,
Onodera Y, Otsuka Y, Handa H, Oikawa T, Hata S, Nishikawa Y, Mizukami Y, Kodama Y,
Murakami M, Fujiwara T, Hirano S, Sabe H. ARF6 and AMAP1 are major targets of KRAS
and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreaticcancer. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17450-17459. doi:10.1073/pnas.
1901765116. Epub 2019 Aug 9. [Overseas journal] *(23) Mazaki Y, Takada S, Nio-Kobayashi J, Maekawa S, Higashi T, Onodera Y, Sabe H. Mitofusin 2
is involved in chemotaxis of neutrophil-like differentiated HL-60 cells. Biochem Biophys Res
Commun. 2019 Jun 4;513(3):708-713. doi:10.1016/ j.bbrc.2019.04.037. Epub 2019 Apr 12.
[Overseas journal] *, ii)(24) Mazaki Y, Higashi T, Onodera Y, Nam JM, Hashimoto A, Hashimoto S, Horinouchi T, Miwa S.
Endothelin type B receptor interacts with the 78-kDa glucose-regulated protein. FEBS Letters,
Mar;593(6):644-651, 2019 [Overseas journal] *, i), ii)(25) Annan DA, Maishi N, Soga T, Dawood R, Li C, Kikuchi H, Hojo T, Morimoto M, Kitamura T,
Alam MT, Minowa K, Shinohara N, Nam JM, Hida Y, Hida K. Carbonic anhydrase 2 (CAII)
supports tumor blood endothelial cell survival under lactic acidosis in the tumor
microenvironment. Cell Commun Signal., Dec 17; 17(1):169, 2019 [Overseas journal] *, ii)(26) Wu PH, Opadele AE, Onodera Y, Nam JM Targeting Integrins in Cancer Nanomedicine:
Applications in Cancer. Cancers, 11(11), 1783, 2019 [Overseas journal] *, i)(27) Fujima N, Shimizu Y, Yoshida D, Kano S, Mizumachi T, Homma A, Yasuda K, Onimaru R, Sakai
O, Kudo K, Shirato H. Machine-Learning-Based Prediction of Treatment Outcomes Using MR
Imaging-Derived Quantitative Tumor Information in Patients with Sinonasal Squamous Cell
Carcinomas: A Preliminary Study. Cancers (Basel). 2019 Jun 10;11(6). pii: E800. doi: 10.3390/
cancers11060800. PubMed PMID: 31185611; PubMed Central PMCID: PMC6627127. [Overseas
journal] *, i)(28) Hayashi T, Nakamura T, Kimura Y, Yoshida M, Someya M, Kawakami H, Sakuhara Y, Katoh N,
5112

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Takahashi K, Ambo Y, Miura K, Motoya M, Tanaka E, Murakawa K, Yamabuki T, Yamazaki H,
Katanuma A, Hirano S; Hokkaido Pancreatic Study Group. Phase 2 Study of Neoadjuvant
Treatment of Sequential S-1-Based Concurrent Chemoradiation Therapy Followed by Systemic
Chemotherapy with Gemcitabine for Borderline Resectable Pancreatic Adenocarcinoma (HOPSBR 01). Int J Radiat Oncol Biol Phys. 2019;105:606-617. [Overseas journal] *(29) Kushiya H, Noji T, Abo D, Soyama T, Tanaka K, Nakanishi Y, Asano T, Nakamura T, Tsuchikawa
T, Okamura K, Hirano S. Treatment of bleeding from a portion of pancreatojejunostomy afterpancreaticoduodenectomy with division of the splenic vein: two case reports. Surg Case Rep.
2019 Aug 8;5(1):128. doi: 10.1186/s40792-019-0687-5. [Overseas journal] *(30) Shimada S, Kamiyama T, Yokoo H, Orimo T, Wakayama K, Nagatsu A, Kakisaka T, Kamachi H,
Abo D, Sakuhara Y, Taketomi A. Hepatic hypertrophy and hemodynamics of portal venous flow
after percutaneous transhepatic portal embolization. BMC Surg. 2019 Feb 18;19(1):23. doi:
10.1186/s12893-019-0486-8. [Overseas journal] *, ii)(31) Sakuhara Y, Nishio S, Hattanda F, Soyama T, Takahashi B, Abo D, Mimura H. Initial experience
with the use of tris-acryl gelatin microspheres for transcatheter arterial embolization forenlarged polycystic liver. Clin Exp Nephrol. 2019 Jun;23(6):825-833. doi: 10.1007/s10157-01901714-9. Epub 2019 Feb 15 [Overseas journal] *(32) Inoue T, Katoh N, Ito YM, Kimura T, Nagata Y, Kuriyama K, Onishi H, Yoshitake T, Shioyama
Y, Iizuka Y, Inaba K, Konishi K, Kokubo M, Karasawa K, Kozuka T, Tanaka K, SakakibaraKonishi J, Kinoshita I, Shirato H. Stereotactic body radiotherapy to treat small lung lesions
clinically diagnosed as primary lung cancer by radiological examination: A prospective
observational study. Lung Cancer. 2018 Aug;122:107-112. doi: 10.1016/j.lungcan.2018.05.025.
[Overseas journal] *, i)(33) Katoh N, Onishi H, Uchinami Y, Inoue T, Kuriyama K, Nishioka K, Shimizu S, Komiyama T,
Miyamoto N, Shirato H. Real-time tumor-tracking radiotherapy and general stereotactic bodyradiotherapy for adrenal metastasis in patients with oligometastasis. Technology in Cancer
Research & Treatment 2018. Accepted [Overseas journal] *, i)(34) Kikuchi Y, Naya M, Oyama-Manabe N, Manabe O, Sugimori H, Kudo K, Kato F, Aikawa T,
Tsutsui H, Tamaki N, Shirato H. Assessment of Coronary Flow Velocity Reserve in the Left Main
Trunk Using Phase-contrast MR Imaging at 3T: Comparison with 15O-labeled Water Positron
Emission Tomography. Magn Reson Med Sci. 2018 Jul 26. doi: 10.2463/mrms.mp.2018-0003.
[Overseas journal](35) Fujima N, Hirata K, Shiga T, Yasuda K, Onimaru R, Tsuchiya K, Kano S, Mizumachi T, Homma
A, Kudo K, Shirato H. Semi-quantitative analysis of pre-treatment morphological andintratumoral characteristics using 18F-fluorodeoxyglucose positron-emission tomography as
predictors of treatment outcome in nasal and paranasal squamous cell carcinoma. Quant
Imaging Med Surg. 2018 Sep;8(8):788-795. doi: 10.21037/qims.2018.09.09. [Overseas journal] *,i)(36) Oyama-Manabe N, Manabe O, Naya M, Kudo K, Tamaki N: Quantitative evaluation of
myocardial ischemia with dynamic perfusion CT. Annals of Nuclear Cardiology, in press[Overseas journal](37) Oyama-Manabe N, Yabusaki S, Manabe O, Kato F, Kanno-Okada H, Kudo K: IgG4-related
cardiovascular disease from the aorta to coronary artery: utility of multidetector CT and PET/CT
in diagnosis and follow-up. Radiographics 2018 Oct 5:180049. doi: 10.1148/rg.2018180049. [Epubahead of print] [Overseas journal](38) Aoike S, Sugimori H, Fujima N, Suzuki Y, Shimizu Y, Suwa A, Ishizaka K, Kudo K. Threedimensional Pseudo-continuous Arterial Spin-labeling Using Turbo-spin Echo with Pseudosteady State Readout: A Comparison with Other Major Readout Methods. Magn Reson Med Sci.
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2018 in press [Overseas journal](39) Sato Y, Nishiofuku H, Yasumoto T, Nakatsuka A, Matsuo K, Kodama Y, Okubo H, Abo D, Takaki
H, Inaba Y, Yamakado K. Multicenter Phase II Clinical Trial of Sorafenib Combined withTransarterial Chemoembolization for Advanced Stage Hepatocellular Carcinomas (Barcelona
Clinic Liver Cancer Stage C): STAB Study. J Vasc Interv Radiol. 2018 Aug;29(8):1061-1067.
[Overseas journal](40) Sakuhara Y, Nishio S, Hattanda F, Soyama T, Takahashi B, Abo D, Mimura H.Initial experience
with the use of tris-acryl gelatin microspheres for transcatheter arterial embolization forenlarged polycystic liver. Clin Exp Nephrol. 2019 Feb 15. [Overseas journal](41) Shimada S, Kamiyama T, Yokoo H, Orimo T, Wakayama K, Nagatsu A, Kakisaka T, Kamachi H,
Abo D, Sakuhara Y, Taketomi A. Hepatic hypertrophy and hemodynamics of portal venous flow
after percutaneous transhepatic portal embolization. BMC Surg. 2019 Feb 18;19(1):23. [Overseas
journal] *(42) Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto
R, Umegaki K, Shirato H. An analytical dose-averaged LET calculation algorithm considering
the off-axis LET enhancement by secondary protons for spot-scanning proton therapy. Med Phys.
2018 Jul;45(7):3404-3416. doi: 10.1002/mp.12991. [Overseas journal] *, i)(43) Demirkiran, Aytac, Agah Karakuzu, Hakan Erkol, Hamdi Torun, and Mehmet B. Unlu.
"Analysis of microcantilevers excited by pulsed-laser-induced photoacoustic waves." Optics
Express 26, no. 4 (2018): 4906-4919. [Overseas journal](44) Sanli, Canberk, Esra Aytac Kipergil, and Mehmet Burcin Unlu. "Simple analytic model forradiotherapeutic X-ray induced acoustic signal as a function of absorption parameters." arXiv
preprint arXiv:1801.05956 (2018). [Overseas journal](45) Lee, J., Cui, Y., Wu, J., Sun, X., Billy W. Loo, J., Diehn, M., and Li, R., Prognostic value andmolecular correlates of a CT-based quantitative pleural contact index in early stage NSCLC. EurRadiol, 2018; 28(2):736-746 [Overseas journal](46) Lee J, Li B, Cui Y, Sun X, Wu J, Zhu H, Yu J, Gensheimer MF, Loo BW Jr, Diehn M, and Li R. A
quantitative CT imaging signature predicts survival and complements establishedprognosticators in stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys, 2018 Nov
15;102(4):1098-1106 (Special issue on ‘Imaging for Radiation Oncology’). [Overseas journal](47) Wu J, Cui Y, Sun X, Cao G, Li B, Ikeda DM, Kurian AW, and Li R. Intratumoral spatial
heterogeneity by perfusion MR imaging predicts recurrence-free survival in locally advanced
breast cancer treated with neoadjuvant chemotherapy. Radiology. 2018 Jul; 288(1):26-35(Highlighted in an accompanying Editorial) [Overseas journal](48) Cui Y, Li B, Pollom EL, Horst KC, Li R, Integrating radiosensitivity and immune gene signatures
for predicting benefit of radiotherapy in breast cancer. Clin Cancer Res. 2018 Oct 1;24(19):47544762 [Overseas journal](49) Wu J, Li X, Teng X, Rubin DL, Napel S, Daniel BL, Li R. MR imaging and molecular featuresassociated with tumor infiltrating lymphocytes in breast cancer. Breast Cancer Research. 2018
Sep 3;20(1):101. [Overseas journal](50) Nam H, Guo M, Lee K, Li R, Han B, Xing L, Lee R, Yu H, Gao H, Tensor Framelet based iterative
image reconstruction algorithm for low-dose multislice helical CT, PLOS One, In press. 2019
[Overseas journal](51) Zhao W, Vernekohl D, Han F, Han B, Peng H, Yong Yang, Min JK, and Xing L. A unified material
decomposition framework for quantitative dual- and triple-energy CT imaging. Medical Physics(Accepted). 2018 Jul;45(7):2964-2977. doi: 10.1002/mp.12933. Epub 2018 May 18. [Overseas
journal](52) Wei Zhao, Dengwang Li, Kai Niu, Wenjian Qin, Hao Peng, and Tianye Niu, Robust beamhardening artifacts reduction for computed tomography (CT) using spectrum modeling. IEEE
7
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ATransactions on Computational Imaging (Accepted). [Overseas journal](53) Pengyuan Qi, Zhitao Dai, Jun Zhang, Hong Quan and Peng H, Investigation of theradiosensitization effect of FePt nanoparticles cluster with Monte Carlo simulation. Nuclear
Science and Techniques (Accepted). [Overseas journal](54) Mizumoto M, Murayama S, Akimoto T, Demizu Y, Fukushima T, Ishida Y, Oshiro Y, Numajiri H,
Fuji H, Okumura T, Shirato H, Sakurai H. Preliminary results of proton radiotherapy forpediatric rhabdomyosarcoma: a multi-institutional study in Japan. Cancer Med. 2018
May;7(5):1870-1874. doi: 10.1002/cam4.1464. Epub 2018 Mar 31. [Overseas journal](55) Kayama T, Sato S, Sakurada K, Mizusawa J, Nishikawa R, Narita Y, Sumi M, Miyakita Y,
Kumabe T, Sonoda Y, Arakawa Y, Miyamoto S, Beppu T, Sugiyama K, Nakamura H, Nagane M,
Nakasu Y, Hashimoto N, Terasaki M, Matsumura A, Ishikawa E, Wakabayashi T, Iwadate Y,
Ohue S, Kobayashi H, Kinoshita M, Asano K, Mukasa A, Tanaka K, Asai A, Nakamura H, Abe
T, Muragaki Y, Iwasaki K, Aoki T, Watanabe T, Sasaki H, Izumoto S, Mizoguchi M, Matsuo T,
Takeshima H, Hayashi M, Jokura H, Mizowaki T, Shimizu E, Shirato H, Tago M, Katayama H,
Fukuda H, Shibui S; Japan Clinical Oncology Group. Effects of Surgery With Salvage
Stereotactic Radiosurgery Versus Surgery With Whole-Brain Radiation Therapy in Patients
With One to Four Brain Metastases (JCOG0504): A Phase III, Noninferiority, Randomized
Controlled Trial. J Clin Oncol. 2018 Jun 20:JCO2018786186. doi: 10.1200/JCO.2018.78.6186.
[Overseas journal](56) Onodera Y, Nam JM, Horikawa M, Shirato H, Sabe H. Arf6-driven cell invasion is intrinsicallylinked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.
Nat Commun. 2018 Jul 11;9(1):2682. doi: 10.1038/s41467-018-05087-7. [Overseas journal] *, i),ii)(57) Aoike S, Sugimori H, Fujima N*, Suzuki Y, Shimizu Y, Suwa A, Ishizaka K, Kudo K. Threedimensional Pseudo-continuous Arterial Spin-labeling Using Turbo-spin Echo with Pseudosteady State Readout: A Comparison with Other Major Readout Methods. Magn Reson Med Sci.
2018 Oct 12. [Epub ahead of print] [Overseas journal](58) Manabe O, Naya M, Oyama-Manabe N, Koyanagawa K, Tamaki N: The role of multimodality
imaging in takotsubo cardiomyopathy. J Nucl Cardiol 2018, doi:10,1007/s12350-018-1312-x,[Epub ahead of print] [Overseas journal](59) Fujimori M, Kamishima T, Kato M, Seno Y, Sutherland K, Sugimori H, Nishida M, Atsumi T.
Composite assessment of power Doppler ultrasonography and MRI in rheumatoid arthritis: apilot study of predictive value in radiographic progression after one year. Br J Radiol. 2018
Jun;91(1086):20170748. doi: 10.1259/bjr.20170748. Epub 2018 Apr 10. [Overseas journal] *, i)(60) Onuma T, Kamishima T, Shimamura T, Kawamura N, Yamashita K, Sutherland K, Takeda H.
Longitudinal CT study of sarcopenia due to hepatic failure after living donor livertransplantation. Quant Imaging Med Surg. 2018 Feb;8(1):25-31. doi: 10.21037/qims.2018.01.07.
[Overseas journal] *, i)(61) Aono S, Ishizaka K, Tha KK, Takamori S, Aoike S, Fujiwara T. [Diffusion Tensor Imaging of
Rotator Cuff: Influence of Arm Position]. Nihon Hoshasen Gijutsu Gakkai Zasshi.
2018;74(4):335-343. doi: 10.6009/jjrt.2018_JSRT_74.4.335. [Japanese journal] *, i)Published books(1) Yasuda K: “Integration of Positron Emission Tomography into Radiation Therapy: With a focus
on the Head and Neck Cancer” Japanese Journal of Clinical Radiology 2018 Sep; 63(9):961-967
3) Verbal presentations- major presentations only.
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- international conferences held in Japan are listed as " [International conference]".
Keynote speeches(1) Shirato H: “Expectations for molecular imaging in next-generation cancer treatment - From theperspective of radiation therapy -”, The 14th Annual Meeting of Japanese Society for Molecular
Imaging, Sapporo, May 23, 2019(2) Shirato H: “Precise and Accurate Radiotherapy for Cancer Treatment”. Taiwan Society for
Therapeutic Radiology and Oncology（TASTRO）, Nov. 9, 2019, Taipei, Taiwan(3) Shirato H: Real-time-image gated proton beam therapy. Hokkaido University China Medical
University Joint Symposium. June 21, 2018. Sapporo, Japan(4) Shirato H: Real-time-image gated proton beam therapy. Hokkaido University China Medical
University Joint Symposium. June 21, 2018. Sapporo, Japan(5) Shirato H: Real-time Tumor-tracking Radiotherapy, 15th SGH Special Lecture, Dec. 1,
2018. Kyoto, Japan(6) Tha KK: Diagnostic Neuroanatomy: Know the Anatomy to Know the Pathology. International
Visiting Professor Program, RSNA-AOSR. Feb 13, 2019. Yangon, Myanmar.
(7) Tha KK: The role of CT and MRI in traumatic brain injury. Special CME Lecture, Wittoria
Hospital. Feb 14, 2019. Yangon, Myanmar.
(8) Tha KK: MRI findings of common congenital anomalies of the CNS. International Visiting
Professor Program, RSNA-AOSR. Feb 15, 2019. Yangon, Myanmar.
(9) Tha KK: The role of CT and MRI in traumatic brain injury. International Visiting Professor
Program, RSNA-AOSR. Feb 15, 2019. Yangon, Myanmar.
(10) Tha KK: Stroke imaging and beyond. International Visiting Professor Program, RSNA-AOSR.
Feb 18, 2019. Yangon, Myanmar.
(11) Tha KK: CT and MRI findings in infectious and inflammatory disease of the CNS. International
Visiting Professor Program, RSNA-AOSR. Feb 19, 2019. Yangon, Myanmar.
(12) Tha KK: Toxic and metabolic diseases of the CNS: how to arrive at correct and timely imaging
diagnosis. International Visiting Professor Program, RSNA-AOSR. Feb 20, 2019. Yangon,
Myanmar.
(13) Tha KK: Recent updates in brain tumor imaging. International Visiting Professor Program,
RSNA-AOSR. Feb 21, 2019. Yangon, Myanmar.
(14) Tha KK: Imaging spectrum of demyelinating and neurodegenerative diseases. International
Visiting Professor Program, RSNA-AOSR. Feb 22, 2019. Yangon, Myanmar.
(15) Tha KK: Tips for Neuroimage interpretation. International Visiting Professor Program, RSNAAOSR. Feb 25, 2019. Yangon, Myanmar.
(16) Tha KK: A Glimpse to Researches in A Clinical Facility. June 15, 2018. Philips Research,
Hamburg, Germany.
Invited lectures [Japanese conference](1) Shimizu S: “Present and future of photon and particle beam therapies”, The 48th Symposium ofcancer control by radiation, Aomori, June 8, 2019(2) Shimizu S: “Radiotherapy options for high-risk prostate cancer - IMRT, heavy particle beam,
proton beam, or brachy?”, The 5th Annual meeting of the Japan Society of Urologic Oncology,
Fukuoka, October 26, 2019(3) Shirato H: “Present proton beam therapy for cancer, Real-time tumor-tracking therapy andpinpointed proton beam irradiation”, Soirée Louis Pasteur 2019, Tokyo, October 30, 2019(4) Tha KK: Electrical Conductivity of the Brain in Normal & Pathological States, The 78th Japan
Radiology Congress, Yokohama, 2019(5) Shirato H: Cancer research and treatment using radiation. 77th Annual meeting of the Japan9
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Cancer Association 2018. Sep. 27 - 29. Sapporo, Japan(6) Shimizu S: “Current status and potential of intensity-modulated radiotherapy / proton beam
therapy for high-risk prostate cancers” The 56th Annual Meeting of Japan Society of ClinicalOncology, Yokohama, October 18, 2018 [Japanese Conference](7) Shimizu S: “Real-time image guided technology and radiotherapy” The 55th Seminar on
Biological Response Science, Hirosaki, November 30 – December 1, 2018 [Japanese Conference](8) Kudo K: “Perspectives on CT / MR perfusion images in Japan”, the 4th Frontier in Acute Stroke
Treatment –FAST Conference-, Tokyo, April 21, 2018 [Japanese Conference](9) Kudo K: “MRI of Alzheimer's disease: QSM image reflecting amyloid pathology and irondeposition” 59th Annual Meeting of the Japanese Society of Neurology, Sapporo, May 24, 2018
[Japanese Conference](10) Kudo K: “Main complaints: Importance of bird’s eye view before focusing in diagnostic imaging
for “Parkinson's symptoms” 59th Annual Meeting of the Japanese Society of Neurology, Sapporo,May 26, 2018 [Japanese Conference](11) Kudo K: “Basics of MR examinations: central nervous system· spine“ The 19th MR Introductory
Lecture, Tokyo, June 9, 2018 [Japanese Conference](12) Kudo K: “Latest PMA developments” Brushup Seminar of NeuroEndovascular Therapy, Kobe,
September 15, 2018 [Japanese Conference](13) Kudo K: “MR diagnosis of Alzheimer’s disease using QSM“, The 58th Annual Scientific Meetingof the Japanese Society of Nuclear Medicine, Ginowan, November 16, 2018 [Japanese
Conference](14) Kudo K: “QSM (Quantitative Susceptibility Mapping)“, Japanese Society for Magnetic
Resonance in Medicine, the 22nd MR Practical Lecture, Tokyo, December 8, 2018 [Japanese
Conference](15) Kudo K: “New diagnostic vistas opened by QSM analysis”, Hi Advanced MR Seminar in Japan,
Tokyo, January 12, 2019 [Japanese Conference](16) Kudo K: “TBD “, Innovative Synthetic Imaging Seminar, Nagoya, February 1, 2019 [Japanese
Conference](17) Kudo K: “Central issues in diagnostic imaging of the central nervous system”, The 48th Annual
Meeting of The Japanese Society of Neuroradiology, Kurume, February 16, 2019 [Japanese
Conference](18) Kudo K: “TBA“, Sakurayama Imaging Seminar, Nagoya, February 22, 2019 [Japanese
Conference](19) Oyama-Manabe N: “Diagnostic imaging for ACHD” The 120th Hokkaido Regional Meetingof the Japanese Circulation Society, Pediatric・Adult Congenital Heart Disease Study Group,
Sapporo, 2018 [Japanese Conference](20) Oyama-Manabe N: “Impact of IQon Spectral CT on cardiovascular diagnostic imaging” The 13th
Chubu Multi-Slice CT Symposium, Nagoya, 2018 [Japanese Conference](21) Oyama-Manabe N: “Unexpectedly frequent IgG4-related cardiovascular lesions”, JapaneseCollege of Radiology, Midsummer Seminar, Kobe, 2018 [Japanese Conference](22) Oyama-Manabe N: “Diagnosis of cardiovascular lesions using multiple contrast, directly
addressing the treatment”, Philips Summer Seminar – Future for Diagnostic Imaging Experts,
Tokyo, 2018 [Japanese Conference](23) Oyama-Manabe N: “MRI-like CT? Development of cardiovascular diagnostic imaging realized
by IQon Spectral CT”, The 27th Annual Meeting of the Japanese Association of CardiovascularIntervention and Therapeutics, Kobe, 2018 [Japanese Conference](24) Oyama-Manabe N: “All about Myocardial Dynamic Perfusion” The 8th 320 row area Detector
CT Seminar, Fukushima, 2018 [Japanese Conference](25) Oyama-Manabe N: “New MRI approaches for cardiomyopathy”, AIMS Cardiac Imaging 2018,10
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Tokyo, 2018 [Japanese Conference](26) Oyama-Manabe N: “New cardiovascular diagnostic imaging using IQon Spectral CT!”, The 77th
Annual Meeting of the Japan Radiological Society, Yokohama, 2018 [Japanese Conference](27) Oyama-Manabe N: “Compressed SENSE imaging conditions and optimization of protocols,
cardiovascular area”, Compressed SENSE Users Meeting, Yokohama, 2018 [Japanese
Conference](28) Oyama-Manabe N: “Advantages of Comprehensive Myocardial Perfusion CT imaging”, The 82nd
Annual Scientific Meeting of the Japanese Circulation Society, Osaka, 2018 [Japanese
Conference](29) Oyama-Manabe N: “MRI for hypertrophic cardiomyopathy“, The 22nd Conference of Shinkinkai,Tokyo, 2018 [Japanese Conference](30) Oyama-Manabe N: “New diagnostic imaging tools for circulatory organs”, “Otaru Circulatory
MRI Conference, Otaru, 2018 [Japanese Conference](31) Oyama-Manabe N: “Respond to any and every heart disease! Cardiovascular MRI Beyond”, The
4th Gunma Heart MRI Meeting, Maebashi, 2018 [Japanese Conference](32) Tha KK: The role of radiomics in evaluation of brain tumors. The 46th Annual meeting of theJapanese Society for Magnetic Resonance in Medicine. September 7, 2018. Kanazawa, Japan.
(33) Tha KK: Can EPT and APT imaging reflect the state of tissues? The 46th Annual meeting of
the Japanese Society for Magnetic Resonance in Medicine. September 8, 2018. Kanazawa, Japan.
(34) Abo D: “Embolization for post-surgical hemorrhagic complications”, The 3rd JPEC, Osaka,
2018 [Japanese Conference]
Invited lectures [International conference](1) Daniel Chang: Modern approaches to pancreatic cancer: updates and contouring session.
Taiwan-American Radiation Oncology Society 7th Annual Meeting, Taipei, Taiwan, October
19, 2019. Invited Speaker.
(2) Tha KK: A Clinician's View on DL-EPT. The 27th Annual Meeting of International Society for
Magnetic Resonance in Medicine, Montreal, 2019(3) Tha KK: Radiomics and Machine Learning in Cancer Research and Therapy. The 9th Imaging
Summit, Taipei, 2019(4) Tha KK: MR-Based Electrical Conductivity Imaging of the Brain in Normal & PathologicalStates, The 2nd International Workshop on MR-based Electrical Properties Mapping, Utrecht,
2019(5) Tha KK: Potential Clinical Applications of Phase-based Electrical Conductivity Imaging, The
5th International Workshop on MRI Phase Contrast & Quantitative Susceptibility Mapping,Seoul, 2019(6) Shimizu S:Overview about clinical indications of moving targets – state of the art photon andproton treatment, Visiting Professor Talk at Mayo Clinic, Rochester MN，USA，2019.10.1(7) Shirato H: Recent Topics in Japan about radiotherapy for lung cancer. Beijing Multidisciplinary Lung Cancer Diagnosis and Treatment Forum 2018. June 14 - 15, China(8) Shimizu S: Clinical application of gated X-ray and particle beam therapy using real-time
images, The 6th Taiwan-Japan Radiation Oncology Symposium (TJROS), Taichung, Taiwan,
May 19, 2018 [International Conference](9) Shimizu S: Four-year treatment experience and efficiency with real time image gated proton
therapy (RGPT) and IGRT system, MD Anderson – Stanford Conference, Houston, USA,
October 25-26, 2018 [International Conference](10) Oyama-Manabe N: ESCR meets ASCI symposium: Non-ischemic Cardiomyopathy “CMR in
Cardiac Sarcoidosis”, European society of thoracic imaging/ European society of cardiovascularradiology, Geneva, 2018 [International conference]
11
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(11) Oyama-Manabe N: Cutting edge cardiac MR techniques: How to use in clinical settings, The
congress of Asian society of cardiovascular imaging, Taipei, 2019 (March) [International
conference](12) Oyama-Manabe N: All about dual energy CT imaging for cardiovascular disease, The congressof Asian society of cardiovascular imaging, Taipei, 2019 (March) [International conference](13) Li R: Radiomic tools to assess early response to cancer therapy, Symposium on Longitudinal
Imaging for Radiotherapy, AAPM annual meeting, Nashville, TN. July 2018 [International
Conference]
Other presentations [Japanese conference](1) Katoh N, Uchinami Y, Abo D, Kawamoto Y, Nakamura T, Takao S, Taguchi H, Shito M, Shimizu
S, Shirato H: “Initial clinical experience with Real-time tumor-tracking proton beam therapy
combined with S- 1, targeting locally advanced pancreatic cancer”, The 14th Studya Group ofPreoperative thrapy for Pancreatic cancer, Sapporo, October 12, 2019(2) Abo D, Soyama T, Morita R, Yoshino Y, Kimura T, Kudo K: Non-vascular IVR for salvage of postoperative complications, The 48th Annual Meeting of the Japanese Society of Interventional
Radiology, Fukuoka, May 29 – June 1, 2019.

(3) Abo D, Soyama T, Morita R, Yoshino Y, Kimura T, Kudo K: The usefulness of guidance softwarefor diagnosing tumor-feeding branches during transcatheter arterial chemoembolization forhepatocellular carcinomas, The 48th Annual Meeting of the Japanese Society of Interventional
Radiology, Fukuoka, May 29 – June 1, 2019(4) Abo D, Soyama T, Morita R, Kamiishi T, Kanaya M, Takayanagi A, Yamazaki Y, Yoshino Y,
Kimura T, Kudo K: “Fundamental study on the utility of microcatheters with movable, locking
tips for coil embolization”, The 48th Annual Meeting of the Japanese Society of Interventional
Radiology, Fukuoka, May 29 – June 1, 2019(5) Abo D: Is embolization only tool of treatment in IVR for post-operative hemorrhagic
complication? ~Paradigm shift from embolization to preservation~, The 31st Meeting ofJapanese Society of Hepato-Biliary-Pancreatic Surgery, Takamatsu, June 13-15, 2019(6) Abo D, Soyama T, Morita R, Yoshino Y, Kudo K: “The latest IVR for intraperitoneal abscesses Secrets of puncture drainage – How specialists approach pancreatic fistula puncture!”, The 32nd
Annual Meeting of the Japan Society for Surgical Infection, Gifu, November 29-30, 2019(7) Yasuda K, Minatogawa H, Dekura Y, Takao S, Tamura M, Tsushima Y, Suzuki T, Kano, S,
Mizumachi T, Matsuo Y, Suzuka M, Yamano S, Onimaru R, Shimizu S, Homma A, Shirato H:
Initial experience of Intensity Modulated Proton Therapy (IMPT) for Pharyngeal Cancer., The
32nd Annual Meeting of the Japanese Society for Radiation Oncology, Nagoya, November 21-23,
2019(8) Katoh N: “No development of proton beam therapy without developments in X-ray therapy”, The
28th Annual Meeting of the Japanese Society of Stereotactic Radiosurgery, Niigata, June 14,2019(9) Abo D: When and how is Target® detachable coils useful in postoperative hemorrhagic
complications after hepato-biliary-pancreatic surgery?, Fukuoka, May 29-June 1, 201912
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(10) Abo D: Update Interventional Radiology and Endoscopy for HBP, Technical tips and trics ofpercutaneous drainage after hepato-biliary pancreatic surgery, The 31st Meeting of JapaneseSociety of Hepato-Biliary-Pancreatic Surgery, Takamatsu, June 13-15, 2019(11) Abo D: “Work and the current situation at our hospital for improving cTACE treatment
outcomes”, The 55th Annual Meeting of Liver Cancer Study Group of Japan, Tokyo, July 4-5,2019(12) Abo D: The usefulness of guidance software for diagnosing tumor-feeding branches duringtranscatheter

arterial

chemoembolizationforhepatocellular

carcinomas,

2nd

HCC

Preceptorship@APPLE2019, Sapporo, August 28, 2019(13) Abo D: Basics of superselective TACE for hepatocellular carcinoma, Seminar for interventional
radiology in Asia-Pacific, Kanagawa, October 25-27, 2019(14) Abo D: “How to acquire outstanding skills and experience?”, 3rd Tokyo IR Club, Tokyo,
November 15, 2019(15) Abo D: “IVR of pancreatic fistulas after pancreatectomy - Focusing on drainage – ”, 3rd Pancreas
cancer workshop, Nara, November 2, 2019(16) Abo D: “Current situation around percutaneous drainage in our department - From diagnosis totreatment –”, 5th IVR Seminar, Izumo, November 15, 2019(17) Abo D: “Current situation around postoperative image diagnosis and percutaneous drainage forhepato-biliary-pancreatic cases in our department”, Latest radiology workshop in Kochi, Kochi,
November 27, 2019(18) Kudo K: “Changes in and latest information of dynamic contrast enhanced CT and MR perfusion
images”, MRI workshop, Miyazaki, January 25, 2020(19) Kudo K: “History and present topics in dynamic contrast enhanced CT and MR perfusion
images”, The 87th Magnetic Resonance Imaging Conference in Hokkaido, Sapporo, February 7,
2020(20) Kudo K: “Diagnosis of dementia by QSM and OEF analysis”, Brain Function Imaging
Conference, Toyama, March 18, 2020(21) Kudo K: “Current situation and future perspectives on PMA, an automated software foranalyzing perfusion images”, The Japan Stroke Society, Yokohama, March 26, 2020(22) Kudo K: “Ischemic penumbra imaging using CT / MR perfusion images”, Study meeting for Low
Invasive Imaging Diagnosis and Treatment, Nagoya, December 20, 2019(23) Kudo K: “QSM analysis of the brain and trunk”, GE Healthcare Seminar, Hirosaki, December
10, 2019(24) Kudo K: “Three aspects of central nervous system and diagnostic imaging”, Japanese Seminar
in RSNA 2019, Chicago, December 1, 2019(25) Kudo K: “Diagnosis of Alzheimer's disease by MRI-QSM”, The 38th Japan Society for Dementia
Research, Tokyo, November 7, 2019(26) Kudo K: “Early diagnosis of dementia by iron deposition analysis on MRI-QSM images”, The 9th
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Japan Society for Dementia Prevention, Nagoya, October 18, 2019(27) Kudo K: “Diagnosis of dementia by quantitative susceptibility mapping: Improvements indiagnostic accuracy by brain surface analysis”, The 47th Japanese Society for Magnetic
Resonance in Medicine, Kumamoto, September 20, 2019(28) Kudo K: “Basics of MR examinations: central nerve and spine areas”, The 20th Introductory
Lecture, Kyoto, June 8, 2019(29) Kudo K: “MRI of neurodegenerative diseases by QSM”, The 17th Radiology Seminar, Shimane,May 31, 2019(30) Kudo K: “Contrast-enhanced CT / MR perfusion imaging for acute cerebral infarction and brain
tumors”, The 78th Japan Radiological Society, Yokohama, April 11, 2019(31) Kudo K: “Early diagnosis of Alzheimer's disease by QSM analysis and its application tocirrhosis”, The 78th Japan Radiological Society, Yokohama, April 11, 2019(32) Hashimoto T: “Proton beam therapy for cancer of pediatric“, The 45th Japanese Society ofPediatric Hematology / Oncology Seminar, Sapporo, February 22, 2020(33) Katoh F, Kudo K, Yamashita K, Baba M, Shimizu A, Oyama-Manabe N, Shirato H: “Evaluationof axillary lymph node metastasis using minimum ADC values of primary tumors in clinicallymetastatic negative luminal A-like breast cancer patients”, The 77th Annual Meeting of theJapan Radiological Society, Yokohama, April 12-15, 2018 [Japanese Conference](34) Oyama-Manabe N: “Gold Medal prize”, The 77th Annual Meeting of the JapanRadiologicalSociety, Study of cardiac late Gadolinium enhancement MRI in musculardystrophy, The 77th
Annual Meeting of the Japan Radiological Society, Yokohama, April 12-15, 2018 [Japanese
Conference](35) Oyama-Manabe N: Symposium: “Insights into Myocardial Ischemia with Dynamic CT
perfusion“, The 77th Annual Meeting of the Japan Radiological Society, Yokohama, April 12-15,
2018 [Japanese Conference](36) Izuka A, Suzuki R, Makinaga A, Miyamoto N: A study of quality evaluation in treatment planof intensity modulated radiation therapy using the gradient measurement tool, The 115th
Scientific Meeting of the Japan Society of Medical Physics, Yokohama, April 12-15, 2018
[Japanese Conference](37) Matsuyama K, Miyamoto N, Makinaga A, Suzuki R: Marker recognition algorithm based onimage similarity using pixel value histogram in real-time tumor-tracking radiotherapy, The
115th Scientific Meeting of the Japan Society of Medical Physics, Yokohama, April 12-15, 2018
[Japanese Conference](38) Matsumoto N, Miyamoto N, Makinaga A, Suzuki R: Evaluation of correlation between internal
fiducial marker motion and deformation field in lung, The 115th Scientific Meeting of the Japan
Society of Medical Physics, Yokohama, April 12-15, 2018 [Japanese Conference](39) Hirayama S, Matsuura T, Ueda H, Fujii Y, Fujii T, Takao S, Miyamoto N, Shimizu S, Fujimoto
R, Umegaki K, Shirato H: Development of an analytical dose-averaged LET calculation method
using a dual-LET-kernel model for spot-scanning proton therapy, The 115th Scientific Meetingof the Japan Society of Medical Physics, Yokohama, April 12-15, 2018 [Japanese Conference](40) Sato S，Kudo A，Sato C，Naganuma R，Uwatoko H，Nishimura H, Shirai S，Takahashi I，Matsushima M, Yabe I, Harada T，Sasaki H: Assessment of central nervous system vasculitis
by using intracranial vessel wall imaging, 59th Annual Meeting of the Japanese Society of
Neurology, Sapporo, May 23-26, 2018 [Japanese Conference]
14
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(41) Soyama T, Yoshino Y, Kato D, Kato H, Morita R, Abo D, Yoshida D, Kudo K: Catheterization
into Challenging Vessels with Steerable Microcatheters, The 47th Annual meeting of theJapanese Society of Interventional Radiology, Tokyo, May 31-June 2, 2018 [Japanese
Conference](42) Abo D, Soyama T, Morita R, Kato H, Yoshino Y, Kudo K, Watanabe M, Koshizuka Y, Kawamura
N, Goto R, Shimamura T: Donor duodenal rupture after pancreas transplantation treated bydirect injection using NBCA, The 47th Annual meeting of the Japanese Society of Interventional
Radiology, Tokyo, May 31-June 2, 2018 [Japanese Conference](43) Li X, Tha KK, Abiko K, Sheriff S, Maudsley A, Ahn S, Urushibata Y, Kudo K, Shirato H:
Distribution of Major Metabolites of the Brain in Normal Adult Population: A Whole-Brain
Magnetic Resonance Spectroscopic Imaging Study, The 46th Annual Meeting of the JapaneseSociety for Magnetic Resonance in Medicine, Kanazawa, September 7-9, 2018 [Japanese
Conference](44) Harada T, Kudo K, Kameda H, Sato R, Shirai T, Bito Y, Fujima N, Tsuneta S, Nogawa T, Maeda
K, Hayashi H, Sasaki M: Phase I study of 17O-labeled water: safety and feasibility study of
indirect proton MRI for the evaluation of cerebral blood flow, The 46th Annual Meeting of theJapanese Society for Magnetic Resonance in Medicine, Kanazawa, September 7-9, 2018
[Japanese Conference](45) Shimura R, Shimizu Y, Harada T, Kameda H, Kudo K: Evaluation of injection rate of Gadobutrol
in perfusion MRI., The 46th Annual Meeting of the Japanese Society for Magnetic Resonance in
Medicine, Kanazawa, September 7-9, 2018 [Japanese Conference](46) Yoshikawa M, Kudo K, Harada T, Sato R, Shirai T, Bito Y: Texture analysis of quantitative
susceptibility mapping in the cirrhotic liver, The 46th Annual Meeting of the Japanese Society
for Magnetic Resonance in Medicine, Kanazawa, September 7-9, 2018 [Japanese Conference](47) Miyamoto N, Matsumoto N, Suzuki R, Takao S, Matsuura T, Fujii T, Hirayama S, Tomioka S,
Shimizu S, Umegaki K, Shirato H: Real-time volumetric image generation with CT image
deformation driven by displacement of internal fiducial markers, The 116th Scientific Meetingof the Japan Society of Medical Physics, Iwate, September 15-17, 2018 [Japanese Conference](48) Fujii T, Takao S, Shimizu S, Matsuura T, Miyamoto N, Hirayama S, Umegaki K, Shirato H: 4DCBCT technique with fiducial marker-position to reconstruct a volumetric image just before thetreatment proton beam delivery in Real-time-image Gated Proton Therapy, The 116th Scientific
Meeting of the Japan Society of Medical Physics, Iwate, September 15-17, 2018 [Japanese
Conference](49) Wu PH, Onodera Y, Shirato H, Nam JM: Radiation increases invasive activity of breast cancer
cells by lysosome exocytosis, The 77th Annual Meeting of the Japanese Cancer Association,
Osaka, Japan, September 27-29, 2018 [Japanese Conference](50) Hashimoto T, Kobayashi H, Iguchi M, Mori T, Sugiyama M, Mogi H, Cho Y, Yamaguchi S,
Onimaru R, Shimizu S, Shirato H: “Clinical benefits of intensity-modulated proton therapy forpediatric medulloblastoma / germ cell tumors requiring craniospinal irradiation, The 77th
Annual Meeting of the Japan Neurosurgical Society, Sendai, October 10-13, 2018 [Japanese
Conference](51) Yasuda K: “Radiation Therapy for Maxillary Sinus Cancer: IMRT and Proton Beam Therapy“,
The 9th Educational Seminar, Annual Meeting of Japan Society for Head and Neck Cancer,
Tokyo, June 13, 2018 [Japanese Conference](52) Oyama-Manabe N: “Tips for effective application of cardiac MRI”, Teine Keijinkai Seminar,
Sapporo, 2018 [Japanese Conference](53) Matsuura T: “Particle beam I, II “, Medical Physics Summer Seminar, Tsunan, September 1-2,
2018 [Japanese Conference]
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(54) Abo D: “Basics ofsuperselective TACE for hepatocellular carcinoma”, Seminar forinterventional radiology, Tokyo, 2018 [Japanese Conference]
Other presentations [International conference](1) Katoh N, Uchinami Y, Abo D, Takao S, Inoue T, Taguchi H, Morita R, Soyama T, Hashimoto T,
Onimaru R, Prayongrat A, Tamura M, Matsuura T, Shimizu S, Shirato H.: Initial Clinical
Outcomes of Real-Time-Image Gated Spot-Scanning Proton Beam Therapy for Hepatocellular
Carcinomas, American Society for Radiation Oncology (ASTRO) 61st 2019 meeting, Chicago,
2019.9.15-19.
(2) Sawamura D, Tha KK, Hashimoto N, Nakagawa S, Narita H, Shirato H.: Differences in Brain
Microstructural Alterations between Bipolar and Major Depression Revealed by Diffusion
Kurtosis Imaging. (Scientific poster), The 27th Annual Meeting of International Society for
Magnetic Resonance in Medicine, Montreal, 2019/5/11-16(3) Li X, Tha KK, Abiko K, Ahn S, Manabe O, Hattori N, Urushibata Y, Kudo K, Shirato H.:
Distribution of Major Brain Metabolite Ratios in Adults: The Observations of Whole Brain
Magnetic Resonance Spectroscopic Imaging Study.(Scientific poster), The 27th Annual Meetingof International Society for Magnetic Resonance in Medicine, Montreal, 2019/5/11-16(4) Sawamura D, Suzuki R, Sakai S, Tha KK: The benefits of combined working memory andattention training: observations in young healthy adults. (Scientific poster), The 7th GI-CoRE
Medical Science and Engineering Symposium, Sapporo, 2019/8/18-19(5) Hamaguchi H, Patzke N, Urushibata Y, Katscher U, Tha KK: Performance of MRI sequences in
evaluation of myelin: a preliminary report (Scientific poster), The 7th GI-CoRE Medical Scienceand Engineering Symposium, Sapporo, 2019/8/18-19(6) Koichi Yasuda: Clinical Usefulness of model-based approach (MBA) in Head and Neck Cancer(Symposiast), The 7th GI-CoRE Medical Science and Engineering Symposium, Sapporo,
2019/8/18-19(7) J Wang, H Shirato, KK Tha.: “Radiomic Analysis of Diffusion Tensor MRI for Discriminating
Parkinson’s Disease”, European Congress of Radiology 2019 (C-1828)(8) J Wang, Y Nomura, H Shirato, L Xing, H Peng.: “Feasibility of X-Ray-Induced Acoustic
Computed Tomography for Breast Imaging by Monte Carlo Simulation”, American Associationof Medical Physics 46 (6), E426-E426(9) Y Nomura, J Wang, H Shirato, S Shimizu, L Xing.: “Fast Spot-Scanning Proton Dose
Calculation Method with a 3-Dimensional Convolutional Neural Network”, American
Association of Medical Physics 46 (6), E291-E291(10) C Sanli, J Wang, M Unlu.: “Absorption Dependence of the X-Ray Induced Acoustic Waves”,
American Association of Medical Physics 45 (6), E593-E594(11) Q Xu, J Wang, H Shirato, L Xing.: “Metal Artifact Reduction with a Deep Image Prior”,
American Association of Medical Physics 45 (6), E704-E704(12)
Kudo K, Sato R, Yamaguchi A, Udo N, Matsushima M, Yabe I, Sasaki M, Harada M,
Matsukawa N, Shirai T, Kawata Y, Ochi H, Bito Y: A Multicenter Study of the Correlation
between the Quantitative Susceptibility Mapping (QSM) of Magnetic Resonance Imaging (MRI)and Amyloid Positron Emission Tomography (PET), AAIC (Alzheimer's Association
International Conference), Los Angeles, 2019.7.12(13) Hashimoto T, Mori T, Takao S, Matsuo Y, Tamura M, Matsuura T, Onimaru R, Shimizu S,
Shirato H.: “Dose-volume statistics comparison of intensity-modulated spot-scanning proton
therapy sparing the inner ear and parotid and conventional X-ray therapy for the whole brain
in pediatric and young adult patients with central nervous system tumors.”, 6th Annual
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PTCOG-NA meeting, Miami, 2019.10.14-16(14) Shimizu S: ”Prospective data registration in proton beam therapy nation-wide evaluation trial(PROTON-NET) using unified treatment protocols with central and onsite monitoring”, Particle
Therapy Co-Operative Group58(PTCOG)，UK，2019.6.10-15(15) Shirato H: “Present Status and Near Future of Quantum Biomedical Science and Engineeringin Cancer Therapy”, June 19, 2019, The Japan China Medical Association(16) Kudo K: ”Oxygen Extraction Fraction (OEF) using QSM in Patients”, 5th International
Workshop on MRI Phase Contrast & Quantitative Susceptibility Mapping, Seoul, Korea、
2019.9.26(17) Kudo K：” QSM Analysis for the Early Diagnosis of Alzheimer’s Disease”, ASFNR, San
Francisco, 2019.11.9
The 7th GI-CoRE Medical Science and Engineering Symposium - FLASH, MBA, & 4DRT, Hokkaido,
Japan, August 2019(18) Erinn Rankin “FLASH radiation therapy protects against radiation induced intestinal injury”(19) Billy W. Loo “Clinical aspects of FLASH”(20) Daniel Chang “Natural language processing for end-of-life predictive modeling”(21) Amato Giaccia “Overview of Recent Advances in Quantum Biomedical Science and Engineering”(22) Lei Xing “Real-world data and Deep Learning in Radiation Oncology”(23) Yasuhito Onodera “Radiotherapy, Distribution of ROS in Cells, and Mitochondria in Cells “(24) Koichi Yasuda “Clinical Usefulness of model-based approach (MBA) in Head and Neck Cancer“(25) Khin Khin Tha “Radiomics in Cancer”(26) Shinichi Shimizu “Future of 4DRT”
The 6th GI-CoRE Summer School for Medical Physics 2019 and Hokkaido Summer Institute 2019 Medical Physics School，Sapporo，2019.8.19-23(27) Shirato H: Overview of Radiation Therapy(28) Giaccia A: Important Concepts in Radiobiology that Impact Radiotherapy(29) Xing L: Treatment Planning for Radiation Therapy(30) Ishikawa M: SBRT and IGRT
(31) Shimizu S： Four-dimensional Radiation Oncology, Real-time-image Guided Radiation therapy(32) Matsuura T: Dose Calculation Algorithms for Spot Scanning Proton Therapy(33) Miyamoto N: Quality Assurance of Four-dimensional Radiation Therapy System(34) Takao S: Patient Setup and Image Guidance Technique in Proton Therapy(35) Umegaki K: Proton Treatment System in Hokkaido University(36) Nam JM: Molecular and radiation biology of cancer invasion(37) Onodera Y: Metabolic alterations and radio-response in cancer(38) Kudo K：O-17 Imaging to Open the Next Door of Neuroscience, 4th ISMRM Japan Chapter,
Chiba, 2019.12.13(39) Harada T, Kudo K, Shimizu Y, Fujima N, Tha KK: Imaging medication-related changes in thecentral nervous system, SNR (XI Symposium Neuroradiologicum), Taipei, March 18-23,2018[International conference](40) Wu PH, Onodera Y, Giaccia AJ, Le QT, Shirato H, Nam JM: Radiation increases invasive
activity of breast cancer cells by lysosome exocytosis, American association for cancer research(AACR) annual meeting 2018, Chicago, April 14-18, 2018 [International conference](41) Dekura Y, Nishioka K, Hashimoto T, Miyamoto N, Suzuki R, Matsumoto R, Osawa T, Abe T,
Maruyama S, Shinohara N, Shirato H, Shimizu S: Determination of the urethra position for
accurate radiation therapy of prostate cancers, 16th Urological Association of Asia Congress
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2018, Kyoto, Apr 18-21, 2018 [International conference](42) Kanaya M, Morita R, Yoshino Y, Soyama.T, Abo D, Kudo K, Kubo K: Combined iodized-oil andgelatin sponge embolization for refractory ruptured hepatocellular carcinoma with dilated
sinusoid-like blood space: A case report, Asian Pacific Association for the Study of the Liver(APASL) Single Topic Conference 2018, Yokohama, May 11-13, 2018 [International conference](43) Hashimoto T, Mori T, Takao S, Yoshimura T, Matsuo Y, Tamura M, Matsuura T, Onimaru R,
Shimizu S, Shirato H: Dosimetric and beam delivery time analysis of pediatric intensitymodulated spot-scanning craniospinal proton irradiation with or without anterior vertebral
body sparing, 57th Annual Conference of the Particle Therapy Co-operative Group (PTCOG57)
and 5th Annual PTCOG-NA meeting, Cincinnati, May 21-26, 2018 [International conference](44) Fujima N, Yonemaya M, Kim E, Aoike T, Aoike S and Kudo K: Diffusion weighted T2-mapping
for the determination of tissue characteristics in patients with head and neck squamous cell
carcinoma; ISMRM 26th Annual meeting, Paris, France, June 16, 2018-4.21; [International
conference](45) Harada T, Kudo K, Sato R, Yoshikawa M, Yabusaki S, Shirai T, Bito Y: Comparison ofreconstruction algorithms for quantitative susceptibility mapping in the upper abdomen,
ISMRM (International Society of Magnetic Resonance in Medicine) 25th Annual Meeting, Paris,
France, June 16-21, 2018 [International conference](46) Tha KK, Katscher U, Ishizaka K, Kudo K, Shirato H: Noninvasive Assessment of Electrical
Conductivity Characteristics of Normal and Diseased Liver Using Electric Properties
Tomography. ISMRM, Paris, 2018(47) Xu Q, Wang J, Shirato H, Xing L: Metal Artifact Reduction with a Deep Image Prior, MEDICALPHYSICS 45 (6), E704-E704., AAPM 2018 annual meeting, Nashville, July 29-August 2, 2018
[International conference](48) Sanli C, Wang J, Unlu M: Absorption Dependence of the X-Ray Induced Acoustic Waves,
MEDICAL PHYSICS 45 (6), E593-E594., AAPM 2018 annual meeting, Nashville, July 29August 2, 2018 [International conference](49) Sanli C, Wang J, Matsuura T, Xing L, Unlu B: A Comparison of the Acoustic Waves Generated
in Proton and Carbon Ion Therapy., AAPM 2018 annual meeting, Nashville, July 29-August 2,
2018 [International conference](50) Fujii T, Takao S, Shimizu S, Matsuura T, Miyamoto N, Hirayama S, Umegaki K, Shirato H: 4DCBCT technique based on fiducial marker-position estimated with dual-orthogonal fluoroscopic
imaging system for Real-time-image Gated Proton Therapy, AAPM 2018 annual meeting,
Nashville, July 29-August 2, 2018 [International conference](51) Miyamoto N, Matsumoto N, Suzuki R, Takao S, Matsuura T, Fujii T, Hirayama S, Tomioka S,
Shimizu S, Umegaki K, Shirato H: Real-time volumetric image generation with CT image
deformation driven by displacement of internal fiducial markers, AAPM 2018 annual meeting,
Nashville, July 29-August 2, 2018 [International conference](52) K. Ueno, T. Matsuura, S. Takao, S. Hirayama, H. Ueda, Y. Matsuo, T. Yoshimura, S. Shimizu,
K. Umegaki, H. Shirato: An Investigation of Biological Impact Caused by Edge-ScatteredProtons in Pencil Beam Scanning Proton Therapy, AAPM 2018 annual meeting, Nashville, July
29-August 2, 2018 [International conference](53) T. Sodeta, T. Matsuura, S. Takao, S. Hirayama, T. Kanehira, N. Miyamoto, K. Nishioka, N. Kato,
S. Shimizu, K. Umegaki, H. Shirato: A Study On the Influence of Changing the Motion
Recognition Rate On the Dose Accuracy of Spot-Scanning Proton Therapy, AAPM 2018 annual
meeting, Nashville, July 29-August 2, 2018 [International conference](54) Shimizu S, Yoshimura T, Katoh N, Inoue T, Hashimoto T, Nishioka K, Takao S, Matsuura T,
Miyamoto N, Ito YM, Umegaki K, Shirato H: Analysis of Beam Delivery Times and Dose Rates
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for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam
Therapy., American Society for Radiation Oncology (ASTRO) 60th 2018 meeting, San Antonio,
October 21-24, 2018 [International conference](55) Onimaru R, Mori T, Yasuda K, Shirato H: Preliminary Study of Cell Survival Modelling
Considering Stochastic Fluctuations in Cell Survival Rates During Radiation Therapy.,
American Society for Radiation Oncology (ASTRO) 60th 2018 meeting, San Antonio, October 2124, 2018 [International conference](56) Yasuda K, Takao S, Matsuo Y, Yoshimura T, Tamura M, Minatogawa H, Dekura Y, Matsuura
T, Onimaru R, Shiga T, Shimizu S, Umegaki K, Shirato H: Intensity-modulated Proton Therapy
with Dose Painting based on Hypoxia Imaging for Nasopharyngeal Cancer., American Society
for Radiation Oncology (ASTRO) 60th 2018 meeting, San Antonio, October 21-24, 2018
[International conference](57) Prayongrat A, Kobashi K, Ito Y, Katoh N, Dekura Y, Amornwichet N, Shimizu S, Shirato H.
Uncertainties of Normal Tissue Complication Probability (NTCP) and NTCP difference between
radiation treatment modality for radiation-induced liver toxicity in Child-Pugh A primary livercancer patients, American Society for Radiation Oncology (ASTRO) 60th 2018 meeting, San
Antonio, October 21-24, 2018 [International conference](58) T. Matsuura et. al.: Target Motion and Specificity of Hadron Therapy, The 50th Congress of theInternational Society of Paediatric Oncology, Kyoto, Japan, November 14 - 19, 2018
[International conference](59) Harada T, Kudo K, Fujima N, Kameda H, Tha KK, Korogi Y, Umino M: Imaging findings inmedication-induced changes of the central nervous system: what radiologists should know
(Traditional Poster), RSNA (The Radiological Society of North America), Chicago, America,
November 24-30, 2018 [International conference](60) Tha KK, Katscher U, Kudo K, Shirato H. Electric Properties Tomography: A New Tool for
Noninvasive Measurement of Tissue Electrical Conductivity. RSNA 104th Annual Meeting,
Chicago, 2018(61) Wu PH, Hsieh CC, Recuenco FC, Onodera Y, Sasaki N, Giaccia AJ, Le QT, Shimizu S, Shirato
H, Nam JM: Carrageenan improves radiation therapy via integrin related molecular mechanism
in cancer cell lines and in vivo, ASCB/EMBO 2018 meeting, San Diego, December 8-12, 2018
[International conference](62) Nishioka S, Wu PH, Onodera Y, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM: Involvementof Rab27 in radiosensitivity of glioblastoma cells. ASCB/EMBO 2018 meeting, San Diego,
December 8-12, 2018 [International conference](63) Oyama-Manabe N:” What radiologists need to know about the utility of detector-based spectral
CT imaging for cardiovascular disease”, the 104th Radiological Society of North America,
Chicago, 2018 [International conference](64) Wang J, Shirato H, Tha KK. “Radiomic Analysis of Diffusion Tensor MRI for Discriminating
Parkinson’s Disease”, 2019 European Congress of Radiology, Vienna, February 27, 2019
[International conference](65) Tha KK: The electrical conductivity characteristics of the normal brain and brain tumors(tentative)., The 2nd International workshop on MR-based Electrical Properties mapping(IMEP), Utrecht, March 16, 2019 [International conference](66) Lin, Hongxiang, Takashi Azuma, Mehmet Burcin Unlu, and Shu Takagi. "Evaluation of Adjoint
Methods in Photoacoustic Tomography with Under-Sampled Sensors." In International

Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 73-81.
Springer, Cham, 2018.
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(67) Shimizu S: Four-dimensional Radiation Oncology, Real-time-image Guided Radiotherapy, The
2nd GI-CoRE GSQ, GSB, & IGM JOINT SYMPOSIUM, Sapporo, July 10, 2018 [International
Conference](68) Shimizu S: Overview about clinical indications of moving targets - state of the art photon andproton treatment, 4D Treatment Workshop for Particle Therapy, Sapporo, December 7-8, 2018
[International Conference](69) Li R: Imaging and molecular biomarkers for precision oncology, Biomedical Informatics
Graduate Program Seminar, Stanford University, November 2018 [International Conference]4) Patent applications
Number of patent applications (number of registered patents):
Japanese patents: 9 (0), overseas patents: 7 (0), total: 16 (0)(1) Radiation Irradiation Planning Apparatus, Clinical Decision Support Apparatus and Program,
Kobashi et al., PCT/JP2016/087808(June/4/2019), US16/467504 (June/7/2019)(2) Radiation Treatment Planning Apparatus, Method and Program, Du et al., JP2019-064207(Mar/28/2018), PCT/JP2019/045904 (Nov/25/2019)(3) Particle Therapy System, Dose Distribution Evaluation System, And Method For Operating
Particle Therapy System, Hirayama et al., JP2018-240752 (Dec/25/2018), PCT/JP2019/044837(Nov/15/2019)(4) Creating Monochromatic CT Image, Tanaka, Sodai et al., JP2019- 92373 (May/15/2019)(5) Radiation Therapy System, Miyazaki et al., US 16/200682 (Nov/27/2018), EP3494887(Nov/26/2018), CN109893775 (Dec/3/2018)(6) Particle beam irradiation system and irradiation planning device, Umegaki et al., JP2018028532 (Feb/21/2018)(7) Radiation Therapy Apparatus, Bed Positioning Device, and Bed Positioning method, Fujii,
Yusuke et al., JP2018-056379 (Mar/23/2018)(8) Radiation Treatment Planning Device, Radiation Treatment System, Radiation Treatment
Planning Method and Radiation Treatment Planning Program, Hirayama, et al., JP2018- 61301(Mar/28/2018)(9) Radiotherapy Device And Radiotherapy Method, Miyamoto et al., PCT/JP2019/020395(May/23/2019)(10) Particle Beam Therapy System, Fujii et al., JP2018-086846 (Apr/27/2018), PCT/JP2019/015812(Apr/11/2019)(11) Method and Device of Motion Tracking for Radiotherapy and Radiotherapy System providing theDevice, Shimizu et al., JP2019-056069 (Mar/25/2019)(12) Particle beam therapy systems, methods to generate CT images to measure particle beams, andCT image generation programs, Shirato H, PCT/JP2019/045902 (Nov/25/2019)(13) 2018-535765, Lesion identification markers for radiotherapy using bone cement and lesion
identification marker kits in radiotherapy, Abo D, Sakuhara Y, Morita R
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(14) 2018-106552, Magnetic resonance imaging equipment, Matsuda G, Kudo K, Sasaki M(15) 2018-160616, Image processing apparatus, image processing methods, image processing
programming, and magnetic resonance imaging equipment, Sato R, Kudo K, Shirai T, Kawata Y(16) 2018-129750, Radiation treatment equipment and radiation treatment methods
Miyamoto N, Umegaki K, Shimizu S, Tomioka S, Takao S5) Awards, etc.
Number of awards: 11 Others: 1(1) Shirato H: The 9th award of JCA-CHAAO, Japanese Cancer Association(2) Abo D: The 9th award of JCA-CHAAO, Japanese Cancer Association(3) Shimizu S: The 9th award of JCA-CHAAO, Japanese Cancer Association(4) Kudo K: “Excellent Paper of the year 2019“, The 47th Japanese Society for Magnetic Resonance in
Medicine(5) Sawamura D, Suzuki R, Sakai S, Tha KK: The benefits of combined working memory and attention
training: observations in young healthy adults. (Bronze award, the 7th GI-CoRE Medical Scienceand Engineering Symposium)(6) Hamaguchi H, Patzke N, Urushibata Y, Katscher U, Tha KK: Performance of MRI sequences in
evaluation of myelin: a preliminary report (Bronze award, the 7th GI-CoRE Medical Science andEngineering Symposium)(7) Oyama-Manabe N: “Gold Medal prize”, The 77th Annual Meeting of the Japan Radiological Society,Study of cardiac late Gadolinium enhancement MRI in muscular dystrophy(8) Tha KK: Guerbet Scientific award (Cum Laude), the 12th Asian-Oceanian Congress of
Neuroradiology(9) Tha KK: 2017 Excellent teacher Award of the Hokkaido University School of Medicine (outstanding
performance award)(10) Tha KK: Global Networking Award 2018, WinGS (Women in Global Science) Project, Hokkaido
University(11) Kudo K: “JJR Excellent Reviewer Award” The Japan Radiological Sociology(12) IEC/TR 62926 Edition 1.0, Medical electrical system - Guidelines for safe integration andoperation of adaptive external-beam radiotherapy systems for real-time adaptive radiotherapy),
May 20, 2019, Shirato H, Hirata Y
6) External grants
Number of awards: 2. Amount of the grant indicates direct cost only.
(1) Japan Agency for Medical Research and Development (AMED), Development of Medical Devices
and Systems for Advanced Medical Services, "Development of Intraoperative On-the-fly
Therapeutic Decision Support System during Quantum Beam Surgery (QBS) and post-QBS
Surgical Operation", 2017-2021, JPY 82,002,165 (projected), Shimizu S(2) Japan Agency for Medical Research and Development (AMED), The Translational Research
program; Strategic PRomotion for practical application of INnovative medical Technology(TRSPRINT), "Establishing non-clinical POC of real-world adaptive proton beam therapy system thatdevelops motion tracking technology and acquisits temporal change of three-dimensional shapeand position of cancer according to the course of time", 2018-2020, JPY 135,318,701, Shimizu S
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● Science outreach(1) Hashimoto T: “Proton beam therapy for cancer of pediatric and AYA age patients”, “New trends incancer medicine”, Hokkaido Univ., November 30, 2019(2) Kudo K: “Challenges for an early diagnosis of Alzheimer’s disease with MRI”, Hokkaido Sapporo
Minami High School, Sapporo, October 24, 2019(3) Taguchi H, “Radiotherapy for lung cancer, Public lectures to improve the awareness of lung cancer
medicine and disease”, Sapporo, August 3, 2019(4) Shimizu S: “Precise consideration of tumor motion during radiotherapy– introduction of spot
scanning proton beam treatment “, Academic Fantasista, Sapporo, February 5, 2020
(5) Shimizu S: “Introduction of Hokkaido University Graduate School of Biomedical Science andEngineering & Development of real-time tumor-tracking proton beam therapy system”, Joint
Symposium between Indonesia and Japan on Nuclear Application, Republik indonesia，2020.3.913● Collaborations with institutions (universities, research institutes, local government, companies, etc.) other thanaffiliated universities
The GSQ has established an international collaboration with the University of Maryland since 2018, aiming
toward standardization of models for predicting adverse reactions to radiation therapy based on research carried out incollaboration with Hokkaido University and Stanford University. The GSQ has previously studied the use of the NTCP
model for predicting effects of radiotherapy on indications for proton beam therapy and during the 4th and 5th (March
14-15, July 10-11, 2017 respectively) GI-CoRE GSQ symposia as well the special seminar held on November 15, 2017,
have invited world leading researchers from the Netherlands and the United States well versed in this research to
Hokkaido University. Consequently, results were published in a special issue of Journal of Radiation Research, coauthored by Professor Hiroki Shirato and Professor Quynh-Thu Le (JRR 2018;59. suppl_1, Radiat Oncol 2019).
Thereafter at the 7th GI-CoRE GSQ Symposium, the GSQ invited Dr. Søren Bentsen (Professor, University of Maryland),Committee Chair on the NTCP Model at the International Commission on Radiation Units and Measurements (ICRU),
an official partner of the WHO, to hold discussions. The proposed GI-CoRE model was evaluated with high confidence
limits as a new and excellent model.
During a meeting with Dr. Bentsen and researchers from New York and Denmark at the 2019 ASTRO Annual Meetingin Chicago (September 15-17, 2019), the GI-CoRE's GSQ, University of Maryland, ICRU, and QUANTEC (the US
NTCP model organization) were suggested to hold a joint workshop aiming at international standardization between
Japan, the US, and Europe. At this joint workshop, Professor Shirato was asked to introduce the GI-CoRE model as ahighly regarded idea towards solving the important topic of selecting appropriate proton therapy currently held aroundthe world. On February 24-25, 2020, the joint workshop was held in Baltimore, Maryland as the GSQ’s first attempt tohold the international meeting overseas.

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References131

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Global Institution for Collaborative Research and Education (GI-CoRE)
Final Evaluation for the Global Station for Quantum Medical Science andEngineering/Global Station for Zoonosis Control projects
1. Aims
The Global Institution for Collaborative Research and Education (GI-CoRE) shall implement an
external evaluation of the research, education and organizational framework of the Global Station for
Quantum Medical Science and Engineering/Global Station for Zoonosis Control projects which started
on April 1, 2014. As the projects have welcomed the final (fifth) year of the implementation period
upon the Fiscal Year 2018, the feedback of this evaluation shall be used to decide whether or not torenew the Global Station project for a further period and improve operations upon the renewed period.
2. Evaluation Structure
A "Hokkaido University Global Institution for Collaborative Research and Education External
Evaluation Committee" shall be established in each of the Quantum Medical Science and Zoonosis
Control Global Stations in accordance with the External Evaluation Implementation Guidelines for the
Hokkaido University Global Institution for Collaborative Research and Education Global Station(Document 2). All evaluations and reports shall be undertaken in English.
□ Global Station for Quantum Medical Science and Engineering External Evaluation Committee
Candidates from Quantum Medical Science GS: 2 foreign members, 1 Japanese member□ Global Station for Zoonosis Control External Evaluation Committee
Candidates from Zoonosis Control GS: 2 foreign members, 1 Japanese member*When the evaluation is complete, the GI-CoRE Steering Committee shall receive a report from theCommittee chair.
3. Evaluation Method□The External Evaluation Committee shall check the contents of the Research Progress Report(Document 3) sent in advance from HU before implementing the on-site investigation, and shallevaluate the evaluation items prescribed in Document 4.
□A 5-level evaluation ratings (S to D) and comments shall be obtained for each "Evaluation Item".
Evaluation
Evaluation Explanation
Ratings
S
Achieved outcomes surpassed the original plan (Outstanding)A
B
C
D

Good progress has been maintained and expected outcomes havebeen achieved (Excellent)
Most expected outcomes have been achieved with some slight delays(Good)
Although certain outcomes were achieved, overall results wereinsufficient (Satisfactory)
No expected outcomes were achieved (Unsatisfactory)

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4. Required Expenses
Travel expenses and honorarium shall be provided to the Evaluation Committee Members (inaccordance with HU regulations). Other expenses required for the External Evaluation (as travel
expenses, honorarium, evaluation report printing expenses, etc.) shall be funded by the budget (nonpersonnel cost) of each Global Station.
5. Publishing of Evaluation Results
Evaluation of this project shall be broadly announced, with the results both published on the relevant
HU websites and published as booklets which are sent to external organizations such as the Japanese
Ministry of Education, Culture, Sports, Science and Technology.

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GI-CoRE Global Station External Evaluation ScheduleYear and Month
Fiscal Year 2017 (2017)

August to November
DecemberAgendaProposal of Evaluation Items and Evaluation Structure (Draft Fixed)
GI-CoRE Steering Committee #13>> Fixing overviews of evaluation items, evaluation structure, schedule, etc.
>> Starting to create the GI-CoRE Research Progress Report (in English)
Selection/Arrangement of the Evaluation Committee Members*Criteria: 2 foreign and 1 Japanese members(candidates who can conduct evaluation in English)*Confirmation of affiliation, main achievements, contact details, etc.

March

Fiscal Year 2018 (2018)

GI-CoRE Steering Committee #14>> Fixing the Evaluation Committee Members and evaluation forms>> Official appointment request (by letters from the GI-CoRE Director)

April

Commencement of the Appointment as the Evaluation Committee
Members

May to June

Completion of the Research Progress Report (in English)>> Forwarding the report to the Evaluation Committee Members for their
document screening

July to August

October

On-site Investigation (by the External Evaluation Committee)
July 19 -20 (for GSZ)
August 8 (for GSQ)
Submission of the Report of the Final Evaluation>> Evaluation Committee Members shall forward their reports of the final
evaluation, based on the document screening and on-site investigation

GI-CoRE Steering Committee #18>> Report of the Final Evaluation by each Chair of the External Evaluation
Committees of GSQ/GSZ on behalf of the three External Evaluation
Committee Members>> Decision of the GSQ/GSZ projects period extension until FY 2019
Fiscal Year 2019 (2020)

March
Fiscal Year 2020 (2020)

Expiration of the GSQ /GSZ projects under the GI-CoRE system

April

Internalization of the GSQ /GSZ projects into the affiliated faculty andcenterJuly

Publication of the Final Evaluation Reports (in English)

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Hokkaido University
Global Institution for Collaborative Research and Education (GI-CoRE)
External Evaluation Implementation Guidelines for the Global Stations
December 15, 2015
Establishment of the Global Institution for Collaborative Research and Education Steering Committee
1. Purpose
These implementation guidelines shall provide the necessary matters for the
implementation of evaluation of the Global Station by non-University affiliated persons(hereinafter the “GS External Evaluation”) of the Hokkaido University Global Institution for
Collaborative Research and Education (GI-CoRE).
2. Committee(1) The "Hokkaido University Global Institution for Collaborative Research and Education
External Evaluation Committee (hereinafter the "Committee")" shall be established by GICoRE in order to perform the matters prescribed in each of the following items.
(i) Implementation of GS External Evaluation(ii) Matters related to the creation and publishing of the report pertaining to the GS
External Evaluation(2) A Committee shall be established for each Global Station that is target for external
evaluation.
3. Composition(1) The Committee shall be composed of third parties other than constituent members of
Hokkaido University, and designated by the Director of GI-CoRE from persons prescribedin each of the following items.
(i) Person designated by the Director of GI-CoRE who is an expert both within and outside
Japan in the research field of the Global Station to be externally evaluated(ii) Persons whom the Director of GI-CoRE deems necessary(2) The Committee members prescribed in the preceding paragraph shall be commissionedby the Director of GI-CoRE after approval by the GI-CoRE Steering Committee.
4. Term of Office(1) The term of office for Committee Members shall be 1 year. However, if a Committee
Member vacancy occurs, the term of office of the successor shall be the remaining term of
the predecessor.
(2) Committee Members may be reappointed.
5. Committee Chair(1) A Committee Chair shall be appointed and selected through mutual election by theCommittee members.
(2) The Committee Chair shall call a Committee meeting as required, and shall chair the said
meeting.

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6. Proceedings(1) A Committee meeting may not be held unless a majority of the members are present.
(2) Committee meeting proceedings shall be decided by a majority of the attending members.
In case of a tie, the Committee Chair shall decide the issue.
7. Implementation of GS External Evaluation(1) The Committee shall implement the GS External Evaluation as prescribed in thefollowing Article.
(2) The Committee may hear the opinions of persons concerned and implement firsthandinvestigations related to the implementation of the GS External Evaluation.
8. Evaluation Items
The Committee shall evaluate the items prescribed by GI-CoRE in each of the following
items.
(1) Items related to research(2) Items related to education(3) Items related to the structure of the research and education center(4) Other items deemed necessary by the Committee
9. Creation and Publishing of the Report
The Committee shall collate the evaluation results prescribed in the preceding paragraphand publish the results in a report.
10. Response to Evaluation Results
The Director of GI-CoRE shall promptly work to implement improvements in view of thereport prescribed in the previous paragraph for items in which improvements are deemednecessary.
11. General Affairs
General affairs for the Committee shall be processed by the Division of International
Relations, International Affairs Department.
12. Miscellaneous Provisions
Necessary matters concerning GS External Evaluation other than those prescribed withinthese implementation guidelines shall be prescribed separately by the GI-CoRE Steering
Committee.
Supplementary Provisions
These guidelines shall come in force on 12 December 2017.

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REGULATIONS FOR THE HOKKAIDO UNIVERSITYGLOBAL INSTITUTION FOR COLLABORATIVE RESEARCH AND EDUCATIONHU Doc. No.151
April 1, 2014
(Purpose)
Article 1 These Regulations shall prescribe the organization and administration of the
Hokkaido University Global Institution for Collaborative Research and Education(hereinafter referred to as "the Institution for Research and Education"), based upon theRules Concerning the Organization of Hokkaido University (HU Doc. No. 31 of 2004),
Article 37(4).
(Objectives)
Article 2 The objectives of the Institution for Research and Education shall be to invite
teaching staff from Japan and overseas with world-class education and research results, topromote international collaborative research and international collaborative education(hereinafter referred to as "international collaborative research and education") that
capitalizes upon the distinctive characteristics of Hokkaido University (hereinafter referred
to as the "University"), and to provide support for international collaborative research being
furthered independently by faculties or schools.
(Employees)
Article 3 A Director and other necessary teaching staff shall be placed in the Institution for
Research and Education.
(The Director)
Article 4 The President shall be appointed as the Director of the Institution for Researchand Education.
2. The Director shall supervise the work of the Institution for Research and Education.
(The assistant director)
Article 5 An assistant director shall be placed in the Institution for Research and Education.
2. A vice president designated by the President shall be appointed as the assistant director.
3. The assistant director shall assist the Director in his or her duties and shall take over those duties in the event of the latter being incapacitated.
(Global stations)
Article 6 The following global stations shall be placed in the Institution for Research and
Education to promote international collaborative research and education that capitalizes
upon the distinctive characteristics of the University.
(1) The Global Station for Quantum Medical Science and Engineering(2) The Global Station for Zoonosis Control(3) The Global Station for Food, Land and Water Resources(4) The Global Station for Soft Matter(5) The Global Station for Big Data and Cybersecurity(6) The Global Station for Arctic Research
2. Full-time teaching staff from the University (including specially appointed academic staff
who come under each item of Article 3 of the Hokkaido University Specially Appointed
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Academic Staff Regulations (HU Doc. No. 35 of 2006). The same applies to Article 7(2)below.) and teaching staff invited from Japan and overseas shall be placed in the Institution
for Research and Education.
3. The period for which a global station is established shall be five years. However, thisperiod can be extended within five years if the steering committee provided for in Article 8
deems it necessary.
(Global station leaders)
Article 7 A global station leader shall be placed in each of the global stations referred to in
the items of Article 6(1).
2. The global station leader shall be one of the teaching staff of the said global station who
has been designated by the Director.
3. The global station leader shall supervise the work of the said global station under the ordersof the Director.
4. The term of office of the global station leaders shall be three years or less, and they can bereappointed.
(Steering Committee)
Article 8 A steering committee shall be placed in the Institution for Research and Education
to deliberate important matters concerning the said institution.
2. The organization and administration of the steering committee shall be prescribed
separately.
(Administration)
Article 9 The administrative work of the Institution for Research and Education shall beprocessed in the Division of International Planning, the International Affairs Department.
(Miscellaneous provisions)
Article 10 In addition to what is prescribed in these Regulations, necessary mattersregarding the operation of the Institution for Research and Education shall be prescribed
separately by the President after approval by the steering committee.
Supplementary Provisions
These Regulations come into force on April 1, 2014.
Supplementary Provisions
These Regulations come into force on April 1, 2015.
Supplementary Provisions
These Regulations come into force on April 1, 2016.
Supplementary Provisions
These Regulations come into force on July 1, 2018.

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REGULATIONS FOR THE GLOBAL INSTITUTIONFOR COLLABORATIVE RESEARCH AND EDUCATION STEERING COMMITTEE
HU Doc. No. 152
April 1, 2014
(Purpose)
Article 1 These regulations shall provide for the necessary matters concerning theorganization and administration of the Global Institution for Collaborative Research and
Education Steering Committee (hereinafter referred to as "the committee"), based upon
Article 8(2) of the Regulations for the Global Institution for Collaborative Research and
Education (HU Doc. No. 151 of 2014, "Regulations for the Institution for Education andResearch" in Article 3).
(Topics for Deliberation)
Article 2 The committee shall deliberate on the issues set forth in item (6) through item (10)of Article 2 of the National University Corporation Hokkaido University Agenda for
Hearing with Faculty Council Rules (HU Doc. No. 42 of 2015, referred to as “Hearing
Rules” in the following paragraph) and deliver opinions to the President.
2. In addition to the matters specified in the preceding paragraph, the committee shalldeliberate the following matters pertaining to the Hokkaido University Global Institution
for Collaborative Research and Education (hereinafter referred to as "the Institution for
Research and Education" in (5) below).
(1) Matters regarding personnel affairs of the faculty (excluding matters set forth in item (6)through item (10) of Article 2 of the Hearing Rules).
(2) Matters regarding the establishment, reform or termination of global stations.
(3) Matters regarding the evaluation of the educational and research activities of global
stations.
(4) Matters regarding budgets.
(5) Other important matters pertaining to the administration of the Institution for Researchand Education.
(Structure)
Article 3 The committee shall consist of the following members:(1) The director of the Global Institution for Collaborative Research and Education(referred to as "the director" in Article 5)(2) The assistant director of the Global Institution for Collaborative Research and Education(referred to as "the assistant director" in Article 5)(3) One vice president designated by the President (excluding the person mentioned in theprevious item)(4) One dean or director from each of the following categories (a-d), each of whom shall be
designated by the Presidenta) The Graduate School of Letters, the Graduate School of Law, the Faculty of
Education, the Research Faculty of Media and Communication, the Faculty of
Economics and Business, the Faculty of Public Policy

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b) The Graduate School of Information Science and Technology, the Faculty of Fisheries
Sciences, the Faculty of Environmental Earth Science, the Faculty of Science, theResearch Faculty of Agriculture, the Faculty of Advanced Life Science, the Faculty ofEngineering, the Faculty of Veterinary Medicinec) The Faculty of Pharmaceutical Sciences, the Faculty of Health Sciences, the Faculty of
Medicine, the Faculty of Dental Medicine, Hokkaido University Hospitald) Each affiliated research institute, each research center, the Field Science Center for
Northern Biosphere(5) Each global station leader as prescribed in Article 7 of the Regulations for the Institution
for Education and Research(6) Other persons whom the President deems appropriate
2. The President shall appoint the committee members mentioned in the preceding item (6)(Term of Office)
Article 4 The terms of office of the committee members indicated in paragraph 1(4) andparagraph 1(6) of the previous article shall be two years. However, the term of office of
substitute committee members shall be the remaining term of office of the previous
committee member.
2. The committee members indicated in the preceding paragraph may be reappointed.
(Committee Chair)
Article 5 The director shall be appointed as the committee chair.
2. The committee chair shall call committee meetings and preside over the said meetings.
3. The assistant director shall take over the director's duties in the event of the latter being
incapacitated.
(Proceedings)
Article 6 The committee cannot validly convene unless at least two-thirds of the committee
members are present.
2 Committee proceedings, other than those prescribed separately, shall be decided by the
majority vote of the attending committee members.
(Attendance of Persons Other Than Committee Members)
Article 7 In cases deemed necessary by the committee, persons other than committee
members may be permitted to attend committee meetings, and explanations or opinions of
the said persons may be heard.
(Committees on Special Issues)
Article 8 Committees on special issues may be established within the committee whennecessary in order to deliberate specialized matters.
(General Affairs)
Article 9 The administrative affairs of the committee shall be processed in the Division ofInternational Planning, the International Affairs Department.
(Miscellaneous Provisions)
Article 10 In addition to what is prescribed in these regulations, necessary mattersregarding the operation of the committee shall be prescribed by the said committee.

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Supplementary Provisions
These regulations come into force on April 1, 2014.
Supplementary Provisions (HU Doc. No. 196 of April 1, 2015)
These regulations come into force on April 1, 2015.
Supplementary Provisions (HU Doc. No. 191 of October 1, 2016)
These regulations come into force on October 1, 2016.
Supplementary Provisions (HU Doc. No. 163 of April 1, 2017)
1. These regulations come into force on April 1, 2017.
2. The dean of the Graduate School of Dental Medicine who was specified as a committee
member in c) of paragraph 1(4) of Article 3 prior to the revision (hereinafter referred to as“the former committee member” in this paragraph) shall be deemed to have been
appointed as a committee member under the revised regulations in c) of paragraph 1(4) of
Article 3 on the enforcement date of these regulations. The term of office of the said
member shall be the remaining term of office of the former committee member on theenforcement date, notwithstanding the revised provisions of Article 4(1).
Supplementary Provisions (HU Doc. No. 182 of June 20, 2017)
These regulations come into force on June 20, 2017 and apply retroactively from April 1,
2017.
Supplementary Provisions (HU Doc. No. 98 of July 1, 2018)
These regulations come into force on July 1, 2018.

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Final Evaluation Report | Global Station for Quantum Medical Science and Engineering, GI-CoRE, Hokkaido University

Final Evaluation Report

外部評価報告書

Published by:
Global Station for Quantum Medical
Science and Engineering,
Global Institution for Collaborative
Research and Education (GI-CoRE),
Hokkaido University

発

Website: https://gi-core.oia.hokudai.ac.jp/gsq/

ウェブサイト : https://gi-core.oia.hokudai.ac.jp/gsq/

July 2020

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行：

北海道大学

国際連携研究教育局（GI-CoRE）

量子医理工学グローバルステーション

2020/10/23 10:18