Bio2Q brings together world-leading researchers in microbiome
studies, organoid technology, metabolite analysis, neural circuit
analysis, and quantum computing. It collaborates internationallywith global leaders in immunology, microbiology, neuroscience,
information science, biochemistry, metabolism, stem cell biology,
and structural analysis.

Keio University Human BiologyMicrobiome-Quantum
Research Center (Bio2Q)

Bio2Q as a
Global ResearchInstitution

Keio University is the first private university in Japan to be
selected for the World Premier International Research Center
Initiative (WPI) program, led by the Ministry of Education, Culture,
Sports, Science and Technology (MEXT). WPI aims to create"globally visible research centers" with exceptional research
environments and exceptionally high research standards,
attracting top researchers from around the globe.

Message toYoung Readers

I hope that even as you grow older,
you never forget to ask 'why?' andcontinue to nurture your curiosity.
Oltea Sampetrean

Keio University Shinanomachi Campus
35 Shinanomachi, Shinjuku-ku, Tokyo
160-8582, Japan

Email: sc-wpi-staff@adst.keio.ac.jp
Web: www.bio2q.keio.ac.jp
Tel: 03-6709-8106 (Weekdays 8:30 AM - 5:00 PM)

ISSUE 01

Bio2Q

Bio2Q:
CenterIntroduction

NOV. 2023

This research center introduction wascomposed based on the remarks ofOltea Sampetrean, Administrative
Director of Bio2Q.

Research is the finest means, thegreatest opportunity, to formulate
hypotheses and verify them. In thisprocess, you can encounter newquestions and unexpecteddiscoveries. The study of the humanbody and the microbiome is filledwith excitement as it involves
continuous learning and discovery
about the microorganisms thatcoexist within our bodies.

Utilizing AI and Quantum
Computing for Analysis

What is Bio2Q?
Bio2Q is a world-class research center located at Keio University.
It conducts research on the connections and interactions
between the microbiome* present in the human body and variousorgans and tissues. By bringing together diverse knowledge andexpertise, it is creating a new interdisciplinary research field
aimed at unraveling the mechanisms that maintain health in thehuman body.

The interactions between the microbiome and organ networks areincredibly complex, and the data involved is extensive. Traditional
computing capabilities sometimes struggle to keep up with theanalysis required. Therefore, at Bio2Q, we are developing
methods that combine AI and quantum computing technologies
for analysis. This approach holds significant potential inuncharted territories where global standards have yet to beestablished.

Research on the Microbiome
and the Human Body
There are trillions of microorganisms present on every surface ofour bodies, such as the skin and the intestinal tract. The
coexistence of humans and microorganisms is a highly importantresearch theme when considering our health, bodily functions,and disease prevention. The collection of microorganisms known
as the microbiome engages in complex interactions with thebody. At Bio2Q, we are researching these interactions taking place
between the body and the microbiome.

Exploring the Secrets ofHealth Beyond Boundaries
Bio 1

QBio 2

Bio2Q consists of three research core units: Multidimensional
Data Analysis Core (Bio-1), Homeodynamics Mechanistic Analysis
Core (Bio-2), and Quantum Computing Core (Q). These units
engage in interdisciplinary research that transcends boundaries.
Data is shared within the facility, allowing one research team toprovide feedback on the findings of another and for specialized
techniques developed by one team to be collaboratively utilizedby various research teams.
Moreover, Bio2Q provides a platform for free discussions acrossresearch teams and cores, similar to the interconnectedness oforgans that maintain health. Through these networks of people,
researchers, and data/technologies/samples, we are exploring thesecrets of health.

Research on Multi-Organ
Coordination
To maintain our health, it has become evident that not only shouldeach organ fulfill its respective roles, but also the interplay
between organs is crucial. The body, with its many organs andmicrobiome, forms a network like a cycle, enabling it to adaptrapidly to environmental changes. Conversely, when suchnetworks break down, they can become the root causes of various
diseases. At Bio2Q, we study the connections and functions
between multiple organs, probing into the mechanisms thatsustain health and the causes of diseases.

* Microbiome refers to the community of microorganisms (such as bacteria, viruses,and fungi) that inhabit a particular environment, in this case, the human body.

Our Goal
Bio2Q's goal is to uncover the essential factors that will allow us tolive healthier, longer lives. For example, making it possible todetect what previously required burdensome tests throughnon-invasive and easy examinations. Enabling the prediction andprevention of future diseases based on data. Developing novel
treatments that didn't exist before and curing previously incurable
diseases. Through such achievements, Bio2Q aims to make asignificant impact on society.