FlowSafe

ABOUT US• Excellence in both flow chemistry and radiochemistry• Dedicated to deliver a solution, not just the equipment• Scientific collaborations with leading radiochemistry groups
System characteristics

System components

HPLC integration

Size

Components included

Components included

465 mm x 424 mm x 372 mm (WxHxD)

2 batch reaction stations up to 200 °C

HPLC pump

2 microreactor stations 1 to 140 °C

HPLC injector valve

Weightback pressure regulator

HPLC injection loop

28.5 kgpressure sensor

HPLC column

vacuum pump with vacuum sensor

HPLC radioactivity detector

Control electronics

liquid dosing systems for accurate control

All integrated into synthesizer

SPE cartridge holder
11 liquid reservoirs

Program control
By PC software (Comecer Absynth)Electrical specifications
FlowSafe
Voltage110-120 VAC / 60 Hz or
220-230 VAC / 50 or 60 Hz
Power consumption< 770W

Founded in 2007 by chemists for chemists, FutureChemistry is a worldwide technology leader
in flow chemistry. We develop, implement and sell microreactor hardware and proceduresfor optimizing and screening chemical reactions and processes for multiple applications.
FutureChemistry is a world leading manufacturer of microreactor systems with a distributor
network and customers in over 20 countries.
Strong knowledge base
FutureChemistry is based at the Technology and Science Park of the Radboud University Nijmegenand has a strong connection to strong connection to this university. Collaborating with
FutureChemistry’s strategic partner Comecer, instruments are built by European high-end
manufacturing partners, finished, configured and thoroughly tested by FutureChemistry in house.
This strong knowledge network ensures fast implementation of scientific and technologicalbreakthroughs for your benefit.
Products and services
Besides complete flow chemistry systems to perform your chemistry, we offer several otherservices such as production of nanoparticles and process development.
Radiolabeling service
Our experienced and dedicated team will gladly assist you with the FlowSafe production of
all your standard and boutique PET-tracers. FutureChemistry has developed and produced
PET tracers in several classes using state-of-the-art methodology including aromatic
nucleophilic 18F chemistry.

Give yourself a head start in PET tracer production and contact FutureChemistry today!

FutureChemistry Holding BV
Toernooiveld 100

FlowSafe’s two microreactor stations enable:

Leading the way in PET tracer
production and development

6525 EC Nijmegen
The Netherlands

1. Synthesis above boiling point of solvent
2. High control over reagents give access to shorter reaction times
and increased reliability and reproducibility

T +31 (0) 24 711 4029
F +31 (0) 24 890 1446
E info@futurechemistry.com
W www.futurechemistry.com/flowscreen
Design: Final Design

3. Shorter reaction times allow working with unstable precursors
and intermediates© FutureChemistry Holding BV 2016. All trademarks acknowledged. Specifications are subject to change without notice.
If FlowSafe is to be used for clinical purposes, user needs to perform clinical validation first.

FlowSafe
Compact, advanced system for the production of PET tracers

Boutique PET tracer development…
with FutureChemistry and FlowSafe you can!

1. Fill liquid reservoirs

Fully automated production of standard radiotracers e.g. 18 F-FDG,
18 F-FLT, 18 F-MPPF and 18 F-FMISO

Flow chemistry technology enables high throughput
reaction screening which greatly speeds up developmentof new PET tracers

Advanced controlled drying of 18 F
2. Load 18F cartridge

Integrated design: no large external housing for e.g. cooling, heating
and control electronics
Unique design for excellent serviceability
Low operational costs due to re-using of components

Give yourself a head start with FlowSafe together withthe our PET tracer team and contact us today

Plug-and-playFlexible design allows combining drying, reacting, purifying andformulating steps yielding a ready-to-use PET-tracer

Our dedicated team of qualified and experienced
PhD radiochemists and chemists can assist you withthe development of your PET tracers. FutureChemistry
has access to the infrastructure for the production anddevelopment of PET tracers

3. Press start

FlowSafe
Safe, flexible and reliable PET tracer production

Batch reactors and flow microreactors: combining best of both worlds
4. Retrieve formulated
PET tracer

The FlowSafe automates production of PET tracers, using an 18F solution directly from acyclotron target or 18F trapped on cartridges
Four independent reaction stations allow separate control over drying, fluorination, deprotection
and formulation
Comecer Absynth software enables you to set up a fully cGMP workflow: Built-in audit trail,user controlled access, history of synthesis development and logging of all process parameters
during a production. All data and actions are fully registered.

Leading the way in PET tracer
production and development

FlowSafe
Compact, advanced system for the production of PET tracers

Boutique PET tracer development…
with FutureChemistry and FlowSafe you can!

1. Fill liquid reservoirs

Fully automated production of standard radiotracers e.g. 18 F-FDG,
18 F-FLT, 18 F-MPPF and 18 F-FMISO

Flow chemistry technology enables high throughput
reaction screening which greatly speeds up developmentof new PET tracers

Advanced controlled drying of 18 F
2. Load 18F cartridge

Integrated design: no large external housing for e.g. cooling, heatingand control electronics
Unique design for excellent serviceability
Low operational costs due to re-using of components

Give yourself a head start with FlowSafe together withthe our PET tracer team and contact us today

Plug-and-playFlexible design allows combining drying, reacting, purifying andformulating steps yielding a ready-to-use PET-tracer

Our dedicated team of qualified and experienced
PhD radiochemists and chemists can assist you withthe development of your PET tracers. FutureChemistry
has access to the infrastructure for the production anddevelopment of PET tracers

3. Press start

FlowSafe
Safe, flexible and reliable PET tracer production

Batch reactors and flow microreactors: combining best of both worlds
4. Retrieve formulated
PET tracer

The FlowSafe automates production of PET tracers, using an 18F solution directly from acyclotron target or 18F trapped on cartridges
Four independent reaction stations allow separate control over drying, fluorination, deprotection
and formulation
Comecer Absynth software enables you to set up a fully cGMP workflow: Built-in audit trail,user controlled access, history of synthesis development and logging of all process parameters
during a production. All data and actions are fully registered.

Leading the way in PET tracer
production and development

FlowSafe
Compact, advanced system for the production of PET tracers

Boutique PET tracer development…
with FutureChemistry and FlowSafe you can!

1. Fill liquid reservoirs

Fully automated production of standard radiotracers e.g. 18 F-FDG,
18 F-FLT, 18 F-MPPF and 18 F-FMISO

Flow chemistry technology enables high throughput
reaction screening which greatly speeds up developmentof new PET tracers

Advanced controlled drying of 18 F
2. Load 18F cartridge

Integrated design: no large external housing for e.g. cooling, heating
and control electronics
Unique design for excellent serviceability
Low operational costs due to re-using of components

Give yourself a head start with FlowSafe together withthe our PET tracer team and contact us today

Plug-and-playFlexible design allows combining drying, reacting, purifying andformulating steps yielding a ready-to-use PET-tracer

Our dedicated team of qualified and experienced
PhD radiochemists and chemists can assist you withthe development of your PET tracers. FutureChemistry
has access to the infrastructure for the production anddevelopment of PET tracers

3. Press start

FlowSafe
Safe, flexible and reliable PET tracer production

Batch reactors and flow microreactors: combining best of both worlds
4. Retrieve formulated
PET tracer

The FlowSafe automates production of PET tracers, using an 18F solution directly from acyclotron target or 18F trapped on cartridges
Four independent reaction stations allow separate control over drying, fluorination, deprotection
and formulation
Comecer Absynth software enables you to set up a fully cGMP workflow: Built-in audit trail,user controlled access, history of synthesis development and logging of all process parameters
during a production. All data and actions are fully registered.

Leading the way in PET tracer
production and development

FlowSafe

ABOUT US• Excellence in both flow chemistry and radiochemistry• Dedicated to deliver a solution, not just the equipment• Scientific collaborations with leading radiochemistry groups
System characteristics

System components

HPLC integrationSize

Components included

Components included

465 mm x 424 mm x 372 mm (WxHxD)

2 batch reaction stations up to 200 °C

HPLC pump

2 microreactor stations 1 to 140 °C

HPLC injector valve

Weightback pressure regulator

HPLC injection loop

28.5 kgpressure sensor

HPLC column

vacuum pump with vacuum sensor

HPLC radioactivity detector

Control electronics

liquid dosing systems for accurate control

All integrated into synthesizer

SPE cartridge holder
11 liquid reservoirs

Program control
By PC software (Comecer Absynth)Electrical specifications
FlowSafeVoltage
110-120 VAC / 60 Hz or
220-230 VAC / 50 or 60 Hz
Power consumption< 770W

Founded in 2007 by chemists for chemists, FutureChemistry is a worldwide technology leader
in flow chemistry. We develop, implement and sell microreactor hardware and proceduresfor optimizing and screening chemical reactions and processes for multiple applications.
FutureChemistry is a world leading manufacturer of microreactor systems with a distributor
network and customers in over 20 countries.
Strong knowledge base
FutureChemistry is based at the Technology and Science Park of the Radboud University Nijmegenand has a strong connection to strong connection to this university. Collaborating withFutureChemistry’s strategic partner Comecer, instruments are built by European high-end
manufacturing partners, finished, configured and thoroughly tested by FutureChemistry in house.
This strong knowledge network ensures fast implementation of scientific and technologicalbreakthroughs for your benefit.
Products and services
Besides complete flow chemistry systems to perform your chemistry, we offer several otherservices such as production of nanoparticles and process development.
Radiolabeling service
Our experienced and dedicated team will gladly assist you with the FlowSafe production of
all your standard and boutique PET-tracers. FutureChemistry has developed and produced
PET tracers in several classes using state-of-the-art methodology including aromatic
nucleophilic 18F chemistry.

Give yourself a head start in PET tracer production and contact FutureChemistry today!

FutureChemistry Holding BV
Toernooiveld 100

FlowSafe’s two microreactor stations enable:

Leading the way in PET tracer
production and development

6525 EC Nijmegen
The Netherlands

1. Synthesis above boiling point of solvent
2. High control over reagents give access to shorter reaction timesand increased reliability and reproducibility

T +31 (0) 24 711 4029
F +31 (0) 24 890 1446
E info@futurechemistry.com
W www.futurechemistry.com/flowscreen
Design: Final Design

3. Shorter reaction times allow working with unstable precursors
and intermediates© FutureChemistry Holding BV 2016. All trademarks acknowledged. Specifications are subject to change without notice.
If FlowSafe is to be used for clinical purposes, user needs to perform clinical validation first.

FlowSafe

ABOUT US• Excellence in both flow chemistry and radiochemistry• Dedicated to deliver a solution, not just the equipment• Scientific collaborations with leading radiochemistry groups
System characteristics

System components

HPLC integration

SizeComponents included

Components included

465 mm x 424 mm x 372 mm (WxHxD)

2 batch reaction stations up to 200 °C

HPLC pump

2 microreactor stations 1 to 140 °C

HPLC injector valve

Weightback pressure regulator

HPLC injection loop

28.5 kgpressure sensor

HPLC column

vacuum pump with vacuum sensor

HPLC radioactivity detector

Control electronics

liquid dosing systems for accurate control

All integrated into synthesizer

SPE cartridge holder11 liquid reservoirs

Program control
By PC software (Comecer Absynth)Electrical specifications
FlowSafe
Voltage110-120 VAC / 60 Hz or
220-230 VAC / 50 or 60 Hz
Power consumption< 770W

Founded in 2007 by chemists for chemists, FutureChemistry is a worldwide technology leader
in flow chemistry. We develop, implement and sell microreactor hardware and proceduresfor optimizing and screening chemical reactions and processes for multiple applications.
FutureChemistry is a world leading manufacturer of microreactor systems with a distributor
network and customers in over 20 countries.
Strong knowledge base
FutureChemistry is based at the Technology and Science Park of the Radboud University Nijmegenand has a strong connection to strong connection to this university. Collaborating withFutureChemistry’s strategic partner Comecer, instruments are built by European high-end
manufacturing partners, finished, configured and thoroughly tested by FutureChemistry in house.
This strong knowledge network ensures fast implementation of scientific and technologicalbreakthroughs for your benefit.
Products and services
Besides complete flow chemistry systems to perform your chemistry, we offer several otherservices such as production of nanoparticles and process development.
Radiolabeling service
Our experienced and dedicated team will gladly assist you with the FlowSafe production of
all your standard and boutique PET-tracers. FutureChemistry has developed and produced
PET tracers in several classes using state-of-the-art methodology including aromatic
nucleophilic 18F chemistry.

Give yourself a head start in PET tracer production and contact FutureChemistry today!

FutureChemistry Holding BV
Toernooiveld 100

FlowSafe’s two microreactor stations enable:

Leading the way in PET tracer
production and development

6525 EC Nijmegen
The Netherlands

1. Synthesis above boiling point of solvent
2. High control over reagents give access to shorter reaction times
and increased reliability and reproducibility

T +31 (0) 24 711 4029
F +31 (0) 24 890 1446
E info@futurechemistry.com
W www.futurechemistry.com/flowsafe
Design: Final Design

3. Shorter reaction times allow working with unstable precursors
and intermediates© FutureChemistry Holding BV 2016. All trademarks acknowledged. Specifications are subject to change without notice.
If FlowSafe is to be used for clinical purposes, user needs to perform clinical validation first.