Unparalleled performance with unique flexibility

The benchtop NMR spectrometer with the most powerful features
Unique resolution

On-line monitoring

Solvent suppression

Autosampler

Multinuclear probes

DOSY Gradient

The resolution of the Spinsolve
magnets is about two times better
than any other commercial solution.
Moreover, it is the only spectrometer
specified at 0.11% of the peakheight.

The ULTRA narrow lines of thismodel make it possible to strongly
attenuate the solvent peaks toconfine them to a region narrower
than 0.2 ppm.

The new Multi-X family of probes
can measure multiple nucleiwith a single instrument in a fully
automatic way.

The flow kit developed for theSpinsolve can be easily mounted
to pump chemicals through theSpinsolve for real time monitoringof reactions.

The compact sample changer
designed for the Spinsolve iscontrolled by the Spinsolve
Software to offer full automation.

The Spinsolve 80 can be equippedwith the strongest pulsed field
gradients (0.5 T/m) for diffusion or
DOSY experiments.

The ULTRA high magnetic field homogeneity of the Spinsolve magnets providesthe highest spectral resolutionThe
only magnet
specified at
0.11%

Resolve the finest structures

Resolve up to J couplings as small as 0.07 Hz likein no other benchtop NMR spectrometer.
5Peak hight [%] Line width [Hz]50

< 0.250.55< 100.11< 20Improve quantification accuracy

In this example, the ULTRA resolution makes it possible tointegrate the acetic acid peak without suffering from any
overlapping with larger adjacent signals. With a lower resolution of 0.4 Hz, the overlapping is more pronounced andthe integrals are affected.

Superior solvent suppression performance

Resolving metabolites in urine at milli-molar concentrations in a few minutes
No Solvent Suppression

Solvent Suppression

IN JUST 8MINUTES

ZOOM
x 2000Urine contains a large number of metabolites dissolved in pure water at very low concentrations. The figure
above shows the comparison of the spectra acquired with (red) and without (black) solvent suppression.
The suppression sequence strongly attenuates the water signal (marked in blue) with impressive efficiency.

Reference for evaluating the performance of the solvent suppression method

To quantify the efficiency of the solvent suppression method, the attenuation and the linewidth of the residual solvent peak need to be measured. While the attenuation factor can be easily determined by comparing
the residual peak with the amplitude of the full solvent peak, the linewidth of the residual signal needs to bemeasured at an absolute height in the spectrum. This absolute height is typically defined by a reference compound added to the sample at a given concentration. In the figure below we measured the residual width at
the height of the alpha anomeric protons of glucose dissolved at 20 mMolar in pure water.

The new generation of fully automatic multinuclear probes

The Spinsolve spectrometers can be equipped with the new Multi-X probes to automatically measure multiple nuclei withthe one instrument. These probes are equipped with a set of electronic switches that eliminate the need for any user intervention to switch from nucleus to nucleus. Electronic re-tuning ensures that calibrations of the system for the different
nuclei remain unaffected when nuclei are switched back and forth. This feature works perfectly with the autosampler tomeasure a set of samples where multinuclear experiments need to be individually pre-defined.

Advanced multinuclear experiments automatically acquired for a SPHOS sample

The most advanced multi-nuclear methods... in one click!
Collect the full set of homo- and hetero-nuclear multidimensional experiments providing decisive information forstructure confirmation in less than one hour.

80 MHz NMR spectra of Gibberelic Acid
Solvent: MeOH-d6
Concentration: 250 mM

1D Proton

gs-HSQC-ME: acquired in just 4 minutes with Nonuniform sampling (NUS)

gs-COSY

gs-HMBC

Gradient
assistedmethods

On-line Reaction Monitoring kit

All Spinsolve models can be equipped with the RM flow kit developed to pump samples through the system for on-line
analysis directly inside the fume hood. This kit includes a glass flow cell that minimizes the dead volume of the flow setup
by using thin capillary tubes that go from the inlets to the center of the cell and maximizes the NMR sensitivity by expanding the tubing in the center, where the NMR coil is positioned. Thanks to the optimized design of the flow cell, the SNR
in flow mode is identical to using standard 5 mm tubes. The kit includes also a peristaltic pump that is controlled by theSpinsolve software to run in continuous or stop flow mode. The flow cell can be easily inserted in the Spinsolve and canbe connected to the pump by means of thin PTFE or peek tubing. The Spinsolve software includes a powerful monitoring module that has been developed to follow reactions in real time. It synchronizes the pump with the measurements ofthe different protocols that are included in the loop and offers advanced data processing tools to display the conversion
curves.

Optimized
Glass FlowCellFull Automation

Increase your sample measurement throughput by integrating the new fully automated autosampler carousel with yourSpinsolve. The autosampler fits on the top of the Spinsolve and is easily added or removed for transportation. The queueof protocols to be run for each sample can be built in just a few seconds and can be edited at any time, even while data
is being collected.

The strongest diffusion gradients for DOSY experiments• Separate the spectra of different components in a mixture by molecular size (DOSY-type experiments)• Measure self-diffusion coefficients to understand molecular mobility (PFG diffusion measurements)

Diffusion Ordered Spectroscopy (DOSY) creates a two-dimensional plot by acquiring a set of spectra as a function of
the amplitude of the gradient. The chemical shift is measured along the horizontal axis, and along the vertical axis theself-diffusion coefficient is shown. In this 2D spectrum the peaks are aligned along horizontal lines. Each of these lines
corresponds to a different self-diffusion coefficient, and therefore a different component of the mixture. We can immediately separate the solvent peak, as well as the other two components, although their diffusion coefficients differ by a little
more than 10%. This makes DOSY a very powerful tool for mixture analysis in NMR spectroscopy when the components
have different diffusion coefficients.

Measurement of self-diffusion coefficients for different nuclei

As the Spinsolve can measure several nuclei on one instrument, the diffusion constants of the species containing thedifferent nuclei can be measured automatically without any retuning. Below we show an example where we measure a
mixture of 1-butyl-3-methylimidazolium tetrafluoroborate (BMIM-BF4) and lithium tetrafluoroborate (LiBF4). The diffusion
coefficients were measured with a stimulated – echo sequence run for each particular nuclei. From left to right we can see
the PGSTE experiments of 50 mg/mL LiBF4 in BMIM-BF4 for proton, fluorine and lithium.

Gradient
0.5 T/mSpecifications• Nuclei: 1H, 19F, 13C, 31P, 29Si, 7Li, 15N, 11B, 23Na (more Available)• Operating frequency: 80 MHz (1H)
• 1H Linewidth:- Classic 50 / 0.55% < 0.4 / 16 Hz- ULTRA 50 / 0.55 / 0.11% < 0.25 / 10 / 20 Hz NEW1
• H Sensitivity (dual channel): > 200:1 for 1% Ethyl Benzene• External hardware Lock system / no need for deuterated solvents• Available with automatic sample changer• 3D PFG gradients optimized for gradient-assisted sequences• Diffusion pulsed field gradients of 0.5 T/m NEW• Standard 5 mm OD NMR sample tubes, 7” long
• Minimum sample volume: 250 ul• Operating Temperature Range: 18° C to 28° C (65° F to 82° F)• Dimensions: 58 x 43 x 40 cm (23” x 17” x 16”)
• Weight: 72.5 kg (160 lb)• Stray Field: < 2 G all around system

Pulse sequences available on the Spinsolve 80 Carbon spectrometer
Proton1D proton (incl. Paramagnetic option)
1D solvent suppression
1D with 19F and 13C decoupling
2D gs-COSY*
2D gs-TOCSY
2D gs-ROESY
2D gs-JRES
T1, T2
PFG-DOSY
Reaction Monitoring

Fluorine
1D Fluorine with 1H decoupling

Carbon1D Carbon with 1H and 19F decoupling

Reaction Monitoring

gs-HMQC
gs-HMBC*

2D F - COSY
2D F - JRES
2D FH - COSY
T1, T2
PFG-DOSYDEPT
APT
HETCOR
gs-HSQC
gs-HSQC-ME**Non-Uniform Sampling (NUS) available

Other sequences available, contact us!

Contact us now for a quote, to request a demo or to measure your samples
Email:
sales@magritek.com
Website: www.magritek.com/contact-us
GERMANY+49 241 9278 7270

UNITED KINGDOM +44 7468 529 615

UNITED STATES+1 855 667 6835

NEW ZEALAND+64 4 477 7096

For a complete listing of our global offices and distributors visit: www.magritek.com/about-us/distributors/