Collaborating Centres
ANNUAL REPORT
Folder eCC_00023062 is in stage Annual_Report_Review
Name of the University, Hospital, Research Institute, Academy or Ministry
National Center for Global Health and Medicine
Name of the Division, Department, Unit, Section or Area
Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital
Reference Number

JPN-94

City

Shinjuku-ku

Title

WHO Collaborating Centre for Prevention, Preparedness and Response to Emerging
Infectious Diseases

Report Year04-2021 to 04-2022

1. Annual report on the agreed workplan
Describe progress made on the agreed workplan. For each activity, detail (1) the actions taken, (2) theoutputs delivered, as well as (3) any difficulties that may have been encountered. Three responses areexpected. [maximum 200 words per activity]. Indicate, if an activity has been completed previously,
has not yet started or has been placed on hold.
Activity 1
Title: At the request of WHO, to provide technical and policy advice to inform WHO’s work in theimplementation of Asia Pacific Strategy for Emerging Diseases (APSED).
Description: • The designated institution has recorded experience in emerging infectious diseases (EIDs), tobe shared with WHO, in order to inform its work in the context of the APSED TAG and with Member States, asappropriate.
• Technical advice from the institution may inform WHO efforts towards the provision of technical and policy
guidance to further support Member States preparedness and response efforts.
Status: ongoing
The Institution provided technical advice on the planning and implementation of infection prevention andcontrol (IPC) and clinical management components through the participation of Dr OHMAGARI to the Meetingof the Technical Advisory Group on the Asia Pacific Strategy for Emerging Diseases and Public HealthEmergencies (APSED lll): Advancing Implementation of the International Health Regulations (IHR) (2005) atthe request of the World Health Organization (WHO) (July 27-30, 2021, online).
Activity 2Title: Under the leadership of WHO, to strengthen Member States preparedness and response capacity
through supporting the IHR Monitoring and Evaluation (M&E) Framework activities in line with the IHR through
APSED.
Description: • It is important to review, improve, and EIDs outbreaks through an objective assessment offacilities by experts.
• This activity (M & E) assess whether systems are working, not just whether capacities are in place.
• WHO may use the deliverables as actual evidence to inform its efforts towards improving and strengthening
existing capacity, learning from real world experiences on the ground (grounds up approach) in line with thevision for the future.
• WHO may use the assessment to inform its activities towards guiding capacity improvement in countries
concerned.

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Status: ongoing
WHO requested the historical IPC review in Japan, 2021. The Institution provided the results through thearticle “Building an Effective Infection Prevention and Control (IPC) System in Japan: A Historical Review”(World Health Organization (WHO) Institutional repository for Information Sharing, in press in June 2021). The
Institution discussed with WPRO and followed activity done through the interviews with six healthcare
professionals and officers at the Ministry of Health or WHO Country Office of several low- and middle-income
countries in WPRO region with an aim to exploratorily identify gaps and challenges regarding theestablishment of an IPC system from January 2022 to May 2022.
Activity 3Title: In support of WHO, to develop and provide in-country training and technical advice on IPC and clinicalmanagement of EIDs to strengthen preparedness.
Description: • There is a strong need for Member States to strengthen develop and strengthen IPC capacities.
It is hope that these activities including trainings, workshops and development of guidance documents wouldachieve the purpose• The deliverables will be used by WHO and Member States to develop and enhance IPC and clinicalmanagement capacities
Status: ongoing
The Institution through Dr. OHMAGARI contributed to the WPRO's COVID response with his presentation anddiscussion on November 22, 2021, with Mongolia, Lao PDR, Vietnam, Philippines, and Cambodia (Planningfor endemic COVID-19 – emerging lessons on clinical management and care pathway in the region), as well
as a discussion on Japan's response to the Omicron outbreak that took place on January 24, 2022 (Learningfrom Japan’s response during the Omicron outbreak).
Requested by WPRO, the Institution through Dr. OHMAGARI, Dr. ISHIKANE, and Dr. NOMOTO held adiscussion with Dr. MATSUI and Dr. NISHIJIMA from the WPRO, and Dr. OTSU from Laos, to support clinicalmanagement and IPC for EID, especially in training and clinical management and IPC guideline in Vietnamand Laos (April 28, 2022). The Institution will continue to support them.
Ongoing collaboration between the Institution and WHO in terms of GOARN training on IPC and clinicalmanagement, the Institution summarized and published an article titled “Facilitating the deployment ofJapanese human resources for responding global outbreaks of emerging and Re-emerging infectious
diseases: A cross-sectional study” (PMID:34635449). The main obstacle to GOARN deployment was found tobe “making time for deployment.” The Institution shared these results to WHO.
Activity 4Title: At the request of WHO, to share information, knowledge, and teaching materials on best practices of IPC
and clinical management of EIDs.
Description: • EIDs outbreaks must be dealt with the right information and knowledge, which requires thesharing of most to date and accurate information and training materials based on the latest studies andexperience.
• WHO may use this information to support its work towards guiding and formulating policies and interventions
for EIDs, as appropriate.
Status: ongoing
Requested by WPRO, the Institution developed and updated teaching materials for IPC and antimicrobial
stewardship (ASP) which are considered to be useful for resource-limited countries. These resources arefocused on hand hygiene, oral care, ASP, ASP teams, and the prevention of surgical site infections inorthopedics. These materials were shared through the Institution’s website after agreement of WPRO.
Activity 5

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Title: At the request of WHO, contribute with technical expertise as needed in support of WHO’s investigationof EID outbreaks in Member States
Description: • To prevent and manage EIDs outbreaks, it is necessary to promptly investigate the source ofinfection, infection route, patient information, and background information from a professional perspective.
• WHO may utilize the findings, as appropriate, to inform its efforts in managing disease outbreaks andsupporting policy development.
Status: ongoing
Requested by the GOARN, the Institution through Dr. TSUZUKI and Dr. ASAI supported to the WPRO as data
management officers from November 2021 to February 2022 and from December 2021 to March 2022,
respectively. They managed epidemiological data associated with the coronavirus disease (COVID-19). They
prepared daily reports on the epidemiological situation regarding COVID-19 in the WPR, which they
communicated to the World Health Organization Health Emergency Team Lead and the Information andPlanning Pillar. They also provided information regarding the epidemic and public health countermeasures inJapan through regular meetings, discussions, and presentations. The deployment of these researchers led tothe appropriate maintenance and improvement of the data aggregation system.
Activity 6Title: To support WHO in providing technical assistance in to improve IPC and clinical management of EIDs
through webinars and workshops, as part of outbreak response
Description: • Experienced IPC specialists and technical expertise are needed to promptly control outbreaks
and other emergencies due to EIDs. So strong capacity development is needed• To deploy this expertise to build Member States capacity and for deployment during outbreaks
Status: ongoing
Between November 17-18, 2021, the Institution co-organized the virtual Global Outbreak Alert Response
Network (GOARN) workshop titled “Orientation to International Outbreak Response with GOARN and WHO
Tier 1.5 Training Workshop 2021”, in collaboration with GOARN, the WHO headquarters, and the WPRO. Thisyear, in addition to Japan, participants were from Australia, Singapore, and Fiji. The program consisted ofcase study group work based on scenarios that GOARN's mission may face in the field and experiencesharing sessions by WHO and Japanese experts who had been dispatched to GOARN as IPC and casemanagement specialists. It was a great success. In total, 31 enthusiastic trainees actively participated in thiscourse.
Since 2019, the Institution has created a JAPAN GOARN Roster for GOARN training graduates who arecandidates for GOARN placement. As of May 17, 2022, 75 experts had been registered.
2. Annual report on other activities requested
Should WHO have requested activities in addition to the agreed workplan, please describe related
actions taken by your institution [maximum 200 words]. Please do not include in this report any
activity done by your institution thatwas not requested by and agreed with WHO.

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Requested by WPRO, in collaboration with CARBGEM Inc., the Institution though Dr. YAMOTO developed anAI application that can identify the name of bacteria from microscopic images of gram-stained bacteria(Bacterial infection teller and treatment estimator: BiTTE). This AI application aims to reduce the occurrence ofAMR due to inappropriate use of antimicrobial agents through image recognition. This was presented at The
Second WHO Innovation Forum in the Western Pacific Region (April 28, 2022).
Requested by WPRO thorough Dr. NISHIJIMA, the Institution through Dr. MORIOKA responded to several
questions on COVID-19 patient care in low- and middle-income countries in WPRO region, and providedrelevant materials based on findings in Japan.
Requested by WRPO, the Institution through Dr. OHMAGARI participated as a panelist in the Human
Resource Development Program session at the GOARN Meeting of Partners, organized by WHO for GOARN
partner Institutions (December 16, 2021). The Institution made a presentation on human resource
development in Japan in terms of emphasizing of capacity building of human resources.
3. Resources
Indicate staff time spent on the implementation of activities agreed with WHO (i.e. those mentioned inquestions no. 1 and no. 2 above). Do not include any data related to other activities done by yourinstitution without the agreement of WHO. Please indicate staff time using the number of “full-dayequivalents” – a day of work comprising 8 hours (e.g. 4 hours work per day for 7 days should berecorded as 3.5 full-day equivalents).
Number of staff involved (either partially or fully)
Senior staff

Mid-career staff

Junior staff, PhD students

1000

Number of full-day equivalents, total for all staff involved
Senior staff

Mid-career staff

Junior staff, PhD students20000Implementation of the agreed workplan activities (i.e. those mentioned in questions no. 1 and no. 2above) normally require resources beyond staff-time, such as the use of laboratory facilities,
purchasing of materials, travel, etc. Please estimate the costs of these other resources as apercentage of the total costs incurred (e.g. if you incurred costs of USD 100 and the value of your staff
time was USD 50 which makes the total of USD 150, please report 33.3% and 66.7%).
Percentage of costs
associated with staff time

Percentage of costs associated with Totalother resources

50.00

50.00

100.004. Networking
Describe any interactions or collaboration with other WHO Collaborating Centres in the context of theimplementation of the agreed activities If you are part of a network of WHO Collaborating Centres,
please also mention the name of the network and describe your involvement in that network[maximum 200 words].

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Collaborating Centres
ANNUAL REPORT
In collaboration with the WHO CC (AMR Clinical Reference Center, the National Center for Global Health andMedicine [NCGM], JPN-98), the Institution conducted the COVID-19 REGISTRY JAPAN (COVIREGI-JP) toclarify the epidemiology and clinical profile of COVID-19 hospitalized patients in Japan (https://covidregistry.ncgm.go.jp/about-the-registry/). As of June 27, 2022, 67,904 cases from 702 hospitals had beenregistered.
At the request of the WHO CC (Bureau of International Health Cooperation, NCGM, JPN-45), the Institution
participated in the 4th WHO CC Conference in Japan on April 2022, which was attended by Dr. KASAI,
Regional Director of the WPRO. At the conference, the Institution through Dr. ISHIKANE presented theactivities conducted towards COVID-19 management.
In collaboration with the WHO CC (Bureau of International Health Cooperation, NCGM, JPN-45), theInstitution through Dr. OHMAGARI and Dr. ISHIKANE published an article titled "Japanese WHO
Collaborating Centres (WHO CCs) fight against COVID-19", (PMID:33937576).

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