The Fifth Bizan Immunology Symposium at University of Tokushima (BISUT5)“Immune System Development, Deviation, and Regulation”
Date:Thursday 3rd March and Friday 4th March 2016
Venue:
Nichia Medical Hall, Kuramoto Campus, University of Tokushima
Guest speakers:
Graham Anderson (University of Birmingham)
Toshiyuki Fukada (Tokushima Bunri University)
Yoko Hamazaki (Kyoto University)
Norimitsu Kadowaki (Kagawa University)
Christoph Klein (University of Munich)Tomohiro Kurosaki (Osaka University)
Yoichi Maekawa (Gifu University)
Hiroshi Ohno (RIKEN Center for Integrative Medical Sciences, Yokohama)
Masahiro Ono (Imperial College London)Satoshi Uematsu (Chiba University)
Host organizers:
Naozumi Ishimaru (Graduate School of Oral Sciences)
Taku Okazaki (Institute for Genome Research)
Mitsuru Matsumoto (Institute for Enzyme Research)
Yoshiyuki Minegishi (Institute for Genome Research)
Tatsuya Saitoh (Institute for Enzyme Research)
Tohru Sakai (Graduate School of Nutrition and Bioscience)
Yousuke Takahama (Institute for Genome Research)
Tetsuo Yamazaki (Graduate School of Pharmaceutical Sciences)
Koji Yasutomo (Graduate School of Medical Sciences)
Contact:
Immunology Program at University of Tokushima (IPUT)
3-18-15 Kuramoto, Tokushima 770-8503, Japan
Phone: +81-88-633-9452
E-mail: takahama@genome.tokushima-u.ac.jp
Sponsored by:Strategic Project for Innovative Research “IPUT”, University of Tokushima
Co-sponsored by:
MEXT Scientific Research on Analysis and Synthesis of Multidimentional Immune Organ Network
Joint Usage Research Center, Institute for Enzyme Research, University of Tokushima

Thursday 3rd March
13:00-13:10

Welcome remarks by Sumihare NojiOpening remarks by Yousuke Takahama

Session 1. Thymus development
Chaired by Yousuke Takahama
13:10-13:40
Graham Anderson (Birmingham)
Regulation of T-cell development by thymic microenvironments
13:40-14:10
Yoko Hamazaki (Kyoto)
Medullary thymic epithelial stem cells ensuring lifelong T-cell tolerance
14:10-14:25
Junko Morimoto (Tokushima)
Novel Aire-dependent tolerogenic lineage(s) of medullary thymic epithelial
cells expressing Ly6 family protein
14:25-14:40
Izumi Ohigashi (Tokushima)
A Foxn1-binding cis-regulatory element for optimal T cell generation

Group photo & coffee
Session 2. Immune regulation
Chaired by Koji Yasutomo
15:10-15:40
Tomohiro Kurosaki (Osaka)
Selection mechanisms of germinal center cells into memory compartment
15:40-16:10
Yoichi Maekawa (Gifu)
Notch controls the maintenance of memory CD4 T cells in health and disease16:10-16:25
Takumi Maruhashi (Tokushima)
Context-dependent inhibition of antigen-specific T cell activation by LAG-3
16:25-16:40
Xuesong Qian (Chiba)
ICOS-ligand B7-H2, expressed on human type II alveolar epithelial cells,
plays a role in pulmonary defense
BreakSession 3. Human immunity
Chaired by Mitsuru Matsumoto
17:00-17:30
Christoph Klein (Munich)
Human immunity - learning from rare patients with primary
immunodeficiency disorders
17:30-17:50
Yoshiyuki Minegishi (Tokushima)
Molecular pathogenesis of hyper-IgE syndrome

Isuien dinner
Hosted by Sumihare NojiChaired by Naozumi Ishimaru

Friday 4th March
Session 4. Gut and nutrition
Chaired by Tohru Sakai
9:00-9:30
Hiroshi Ohno (Yokohama)
Function and differentiation of intestinal epithelial M cells
9:30-10:00
Satoshi Uematsu (Chiba)
Acute and chronic radiation injury in small intestine
10:00-10:15
Tohru Sakai (Tokushima)
Sudachitin, polymethoxylated flavone from Citrus sudachi, regulates
antigen-specific immune responses
10:15-10:30
Jun Nishida (Tokushima)
Regulation of Peyer's patch by PTPRK
CoffeeSession 5. Immune homeostasis
Chaired by Taku Okazaki
10:50-11:20
Masahiro Ono (London)
Time-dependent dynamics of regulatory T cell differentiation in vivo
11:20-11:50
Toshiyuki Fukada (Tokushima)
Zinc signaling: An emerging player for epithelial tissue homeostasis
11:50-12:10
Tetsuo Yamazaki (Tokushima)
ER as a potential therapeutic target for protein aggregation disease
12:10-12:25
Kou Motani (Tokushima)
Cyclic GMP-AMP-dependent and -independent cytokine induction byself-DNA

Lunch with students (12:30-13:30)
Organized by Yasusei Kudo & Kensuke Takada

Session 6. Disease regulation
Chaired by Tetsuo Yamazaki
13:30-14:00
Norimitsu Kadowaki (Kagawa)
Combination of targeted therapy and immunotherapy for cancer
14:00-14:15
Takeshi Wada (Tokushima)
Exacerbation of oxazolone-induced atopic dermatitis in mouse model ofhyper-IgE syndrome
14:15-14:30
Hitoshi Nishijima (Tokushima)
Augmented expression of the autoimmune regulator (AIRE) induces
paradoxical development of polymyositis-like autoimmunity in mice
14:30-14:45
Tomoyuki Kondo (Tokushima)
Acceleration of tumor growth due to dysfunction in M1 macrophages andenhanced angiogenesis in an animal model of autoimmune disease