Division of Biofunctional Chemistry
The Chemical Society of Japan

Vol. 32, No.1 (2017. 6. 19)

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巻頭言	
 

創造の動機	 	 	
 京都大学エネルギー理工学研究所	
 エネルギー利用過程研究部門	
 
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3

研究紹介	
  第 97 春季年会	
 優秀講演賞	
 Targeting and Tuning Conformational Equilibria in Non-Coding RNAs: aPromising Approach for Biomedical Applications
FIBER, Konan University, Kobe, Japan
Ambadas B. Rode
1. Abstract
Both prokaryotic and eukaryotic cells contains large number of RNA transcripts that lacks protein-coding
capacity. These non-protein coding RNAs (ncRNAs) controls gene expression at post-transcriptional level either
acting within the same transcript (cis-acting) or acting on other separate RNA molecule (trans-acting) through
RNA-RNA interaction. In certain cases both cis-acting and trans-acting modes of regulation occur throughswitching the RNA conformational equilibrium between mutually exclusive two conformers. Shift of the RNA
conformation toward one of the conformer resulting in inhibition or activation of gene expression. Thus,
investigation of factors that affects the ncRNAs conformational equilibria is important for understanding theregulation mechanism. We have studied the effects of inherent and cellular factors on conformational equilibria
of regulatory ncRNAs from human and bacteria. These studies helped us to understand the gene regulation
mechanism of the ncRNAs in human and bacteria that will enable selection of ncRNAs as pharmaceutical targets
and also as a tool for synthetic biology applications.
2. Introduction
The cell cytoplasm is crowded with biomolecules.1 It is
now well established that the RNA is not just passive
messenger of genetic information, however it performs
diverse functions including molecular recognition, gene
regulation, and catalysis etc. The major portion (~97%) oftranscribed RNAs are non-protein coding RNAs (ncRNAs) 2(Figure 1a), which play important roles in cellular
homeostasis and are involved in many human diseases
including cancer. Thus, there is growing interest inunderstanding ncRNAs functions. For examples, RNA

G-quadruplex (G4) formed in non-coding 5′ untranslated
region (UTR) of human oncogene mRNAs regulates gene
expression (Figure 1b). Riboswitches, which are cis-acting
gene-regulatory elements mostly located in 5′ UTR ofbacterial mRNAs, adopt alternative conformations in
response to ligand binding that turns on or off gene
expression (Figure 1c). Herein, we have studied the effects
ofinteractionofcellularabundant

ncRNAsonhairpin-G-quadruplex conformational equilibrium in 5′UTRof human oncogene mRNAs3 and effect of primary
sequence and secondary structure on ligand binding
function of riboswitches, respectively.4, 5

4

Figure 1. a) Estimate of various classes of RNA
present in human cells; b) 5’ UTR locatedG-quadruplex mediated inhibition of translationin human; c) Riboswitch mediated gene
regulation in bacteria.

3. Effect of tRNAs on hairpin-G-quadruplex conformational equilibria mediated translation
Owing to RNA G4s significant roles in regulation of
biological processes, they are emerged as importanttherapeutic targets for the treatment of diseases including
cancer. In certain cases the G4s folding competes withformation of canonical hairpin (Hp) conformers (Figure2a).6, 7 The Hp-G4 equilibria are observed in 5′ UTRs of
oncogenes.3 The equilibria are also observed at maturationsites of precursor micro RNA (miRNA).8 Thus the transition
betweentwo

distinctinterconverting

G4

and

Hp

conformations has a profound influence on oncogene
expression3 or dicer mediated miRNA maturation.8 Transfer
RNA (tRNA) is one of the most abundant ncRNAs,
accounting for about 15% of total cellular transcripts(Figure 1a). In this study, we investigated effect of highconcentration of tRNA, which mimics the overexpression oftRNA in certain cancers, on Hp-G4 equilibria in the 5′ UTR
of oncogenes sequences. When we monitored RNA
conformational transition from Hp to G4 conformer using
RNA oligonucleotide (Figure 2a) labeled with fluorophores,
we observed decrease of FRET signal intensity in the3presence of 20 µM tRNA (Figure 2b). The result suggested
that Hp-G4 equilibrium is shifted (~60 %) towards thehairpin conformer. We also evaluated the influence of tRNAon the G4 mediated translation suppression by using
reporter mRNAs, which have HpG4 sequences derived from
5′ UTR of oncogene mRNAs. In all of the HpG4 sequences,
the relative gene expression levels evaluated from luciferase
activity were higher (up to 3.1-fold) in the presence of 20

Figure2.
a)Predicted
hairpin-G4
conformational equilibria in HpG4-1 sequence(Fam=6-carboxyfluorescein;Tam=tetramethylrhodamine); b) FRET curves of Hp to
G4 transition in presence of 0 or 20 µM tRNAconcentration after addition of KCl ; c) Chosen
HpG4 sequences (upper panel); Relative
luminescence signals obtained from reporter
mRNAs in the presence of 0 or 20 µM tRNA(lower panel).

µM tRNA than in the absence of tRNA (Figure 2c).3 These results indicate that the Hp-G4 equilibria mediatedtranslation can be modulated by targeting the tRNAs expression for therapy.
4. Effect of base-pair variation in FMN riboswitch aptamer on ligand binding and riboswitch function
Riboswitches function at the level of transcription and translation and their function depends on ligand
binding properties (kinetics and affinity) of their aptamer domain.4 We have chosen flavin mononucleotide(FMN) riboswitch due its presence in pathogenic and biotechnologically important bacterial strains. FMN ligand
decreases its fluorescence upon binding to riboswitch aptamer domain (Figure 3a).4,5 We have identified tuning
regions that modulate ligand binding kinetics and affinity in FMN riboswitch aptamers by comparative analysisof kinetic parameters, which we obtained from stopped-flow measurement (Figure 3b) of several natural andmutated FMN riboswitch aptamers. Dissociation rate constants (kd) and affinities (KD) strongly depended on
identities of base pairs in the aptamer stem regions.4 The results suggested that the compensatory base-pairvariations in the stem regions are5conserved to tune the riboswitch function. Based on the
results, we constructed two synthetic riboswitches from thesame natural aptamer domain by rationally modifying thestem regions. We observed ~10-fold differences of EC50
values of FMN-mediated suppression of gene expression
between these two riboswitches (Figure 3c) that corresponded
to the differences of KD (data not shown) between theirparental aptamer.4 These result suggested that the gene
expression can be controlled rationally by adjusting ouridentified tuning regions for biotechnological applications.
4. Conclusion
We have studied the effect of cellular abundant ncRNAs
as well as effect of RNA nucleotide sequence on theconformational equilibria of regulatory ncRNAs in human andbacteria, respectively. We also demonstrated that theconformational equilibria in ncRNAs can be rationally
modulated by altering the other cellular RNA concentrations
or by altering the nucleotide sequence in the important regionsthat enables regulation of the gene expression. These studies
are important to understand the gene regulation mechanism inhumans and bacteria. We consider that the regulatory ncRNAs
are promising therapeutic targets and able to be a usefulmodule for biotechnological applications.
Acknowledgement

Figure 3. a) Schematics of riboswitch
aptamer-FMN binding; b) Time dependent
FMN fluorescence after addition of 0 to 300
nM of RNA aptamer; c) Luciferase activity forriboswitches with natural aptamer domain andrationally designed aptamer domain obtained
from coupled transcription/translation assay inpresence of various concentration of FMN.

I would like to show my gratitude to my supervisor Prof. Dr. Naoki Sugimoto, Director, FIBER, Konan
University and Dr. Tamaki Endoh, Associate Professor, FIBER, Konan University, for their guidance and help.
Without their support, this research works would not have been possible. This work was funded by JSPS
Postdoctoral Fellowship for Overseas Researchers (to A.B.R.), JSPS KAKENHI Grant Number (15F15345) and
Grants-in-Aid for Scientific Research and MEXT (Japan)-Supported Program for the Strategic Research
Foundation at Private Universities (2014–2019), and the Hirao Taro Foundation of the Konan University
Association for Academic Research.
References
1.
2.
3.
4.
5.
6.
7.
8.

S. Nakano, D. Miyoshi, N. Sugimoto, Chem. Rev., 2014, 114, 2733.
A. F. Palazzo, E.S. Lee, Front. Genet. 2015, 6, 2.
A. B. Rode, T. Endoh, N. Sugimoto, Angew. Chem. Int. Ed., 2016, 55, 14315.
A. B. Rode, T. Endoh, N. Sugimoto, Angew. Chem. Int. Ed., 2015, 54, 905.
A. B. Rode, T. Endoh, N. Sugimoto, Bull. Chem. Soc. Jpn 2015, 88, 946.
T. Endoh, A. B. Rode, S. Takahashi, Y. Kataoka, M. Kuwahara, N. Sugimoto Anal. Chem., 2016, 88, 1984.
A. Bugaut, P. Murat, S. Balasubramanian, J. Am. Chem. Soc. 2012, 134,19953.
G. M. Arachchilage, A. C. Dassanayake, S. Basu, Chemistry & Biology 2015, 2, 262.

6

研究紹介	
  第 97 春季年会	
 優秀講演賞	 	
 ペプチドナノファイバーの光誘起成長を利用した
走光性リポソームの構築
鳥取大学大学院工学研究科	
  稲葉	
  央
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Ƥΐ΍GϏǞʩ˻zАo]Bv9LdsCaΈˈdp_8̦͐eLwl^b¦¿«|Æ T4 bˣɫRvÄ§ζğƤϵzĥˡP8ˑbUd̺͔͚ήϖőȂdΊɯq̺͔ęğƤωϓjdȂˡzƈŤP]HW 19˚że8°­8Ä§ζ8DNA a`z̽mŜyTWğƤ¶dİ΀zʄ̹

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2. 光誘起ペプチドナノファイバー成長 °­qÄ§ζd͜ǔАŜȭĺzƒϪħ˃^ĦǺP8κğƤʁϘdǯȘÅΊВzȺvΔmG

̰ı˶b͹yw]Bv 29ĐȂ̩ȇ}µ¤ϯzĥˡP8Đħ˃bsZ]°­¡¤«|¦ÆdǯȘzΚιPWúGƈŤNw]BvG8UdµÄ_ƉȝzŞɕbĦǺPWúeƈŤNw]BaFZ
W9Ǯ̜̇Ʊ^e8β-sheet ǯȘ͕zȫ[ FKFEFKFE °­

_8АŜȢĦϪóŏh̝ЀĦǺϪó_P]d DNAлdA20мzĐĠɃ}µ¤ϯ^ϙ̿RvL_^8Đħ˃bsv°­¡¤«|¦ÆȘϽdɕ̝ЀĦǺbȘĲP]Bv9ǮĢϿ˳PWĐĠɃ}µ¤ϯ X zˡBW Conjugate 1 e8ʙˀʳÐ^e
DNA d}¢ÄȇdWob͜ǔАŜGȢĦNw]Eu8Đˌƾл365 nmмbsZ]°­Ϫó_

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DNA ϪóGΊВRvL_^8°­Ϫód͜ǔАŜbsZ]¡¤«|¦ÆzǯȘRvL_GɎt

3

F_aZWлFigure 1aм 9dA20 _˽Ϳ˶a DNA ^Av dT20 zŹƮPW¾ƄɮÉ^ Conjugate 1z¥¬¿Æ¼ÄNT8Đˌƾz͹CL_^8ó͉ϣȤ˶b°­¡¤«|¦ÆzȘϽ

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Ňʸɢ 14 secм9Conjugate 2 jdĐˌƾbsv¡¤«|¦ÆǯȘe TEM ^̈ΙPW9¡¤«|¦ÆǯȘbðC˄ǤÉɌzΓüPW_Lx8Conjugate 2 eĐˌƾ˼Ƕb˄ǤGÉɌP8Conjugate 1 bʕksuϗI«|¦ÆzǯȘP]BvL_GɎtF_aZW9LdsCb8Đbsv°­¡¤«|¦ÆȘϽdɕ̝ЀĦǺbȘĲP8ĐȂ̩ϪózƐDvL_^UdϗǤpĦǺ^HvL_z̋PW9
3. 走光性リポソームの創製 Av̘d̺ͫлη˱ͫÅ¿¿}a`м
e8UdˏКbEJv}Ä«|¦ÆǯȘzȳϛı_RvL_^8ƵÑ̺͔ęzÏϛϝĺRvL_G̅tw]Bv9LdsCa˟ːdϝĺzʄćPW8ÏϛϝĺRvğƤ¸ÆÆϿ˳G˹{b͹ayw]Bv 49ˑb8Đa`dƒϪħ˃bsZ]ϝĺdɅŠqµÄzĦǺRvʉÍèdğƤ¸ÆÆGʩ˻zАo]Bv9UL^8ĪϑPW
Conjugate 1 ŏh 2 GĐˌƾbsZ]¡¤«|
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}Ä¿³Æ¶dˏКbƯ;RvL_^8ĐˌƾbsZ]ÏϛϝĺRvθĐȇ¿³Æ¶dʁ̬zΔmW9ĐˌƾbsZ]¿³ Figure 2. Conjugate zˡBWθĐȇ¿³Æ¶dʁ̬Æ¶ͼК^Ǆȝ˶bˬʙȇd¡¤«|¦
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Ǥe Conjugate 2 dɅGϗBL_GɎtF_aZW9Lwe8Conjugate 1 ŏh 2 dĐĠɃϗǤ8¡¤«8

|¦ÆǯȘϗǤG¿³Æ¶dϝĺϗǤbőɐNwWWoX_ȳƮNwv9ÇɅÄÂÆÀ_P] dA20 z΁ŜŀPW¿³Æ¶^eĐˌƾP]p¬¾ÄϝĺdmG̈ΙNw8ɅŠȇdAvĺHe
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4. おわりに éÉ8°­d͜ǔАŜȭĺzĐbsZ]ĦǺP8UwzğƤϝĺȺøj_ǇϿPWÇϙḋ̜b[B]ƈŤPW9ɝǶb8ǻǁ̪zˡBWɄPBÆ´b[B]̻äRv9̺͔вɹdÇ̘^Av
ǻǁ̪лMicrotubuleмe8αºÆ¬¿Ä8βºÆ¬¿Äd®Â´ÆGϱŜP]ǯȘNwvę
Ǵ 14 nm8ϽNɀµm~ɀńµm dºÆ¬ʁϘö^Av9Lwl^bǻǁ̪ƒϪͼКjdğƤāЩbsZ]8ƄɮÉ^ϝĺRvğƤ¸ÆÆϿ˳qϴǈ¡¤̯ƤdА̛G͹yw]HW 59ÇɅǻǁ̪dęϪ̝Ѐzĥˡ^Hwf8͗ϱŜbsvğƤȼĞzĥˡPWωϓ¶a`dɄWaǇϿGɢǵ^Hv
pdd8ǻǁ̪ęϪbğƤzǀĒRvȞʧë̠Nw]BaFZW9UL^8ǻǁ̪ЁϙÄ§ζ
Tau dę8ǻǁ̪ęϪdˬʙȇ³b̿ŜRv_ȳƮNwvϭġFt8ǻǁ̪ęϪͼКb̿ŜRvл TP1 8 TP2 м z ΐ ΍ P W 9 TP1 л KHQPGGGKVQIINKKLDLGGGC м ŏ h TP2°­лCGGGKKHVPGGGSVQIVYKPVDLмdɥ̣d Cys bͶĐ̸ͤzŀƨāЩP8ºÆ¬¿Ä_΁ŜŀǶbϱŜNTvL_^8ͶĐʃΥ°­dǻǁ̪jdęĿzΔmWлFigure 3м9CLSM ^ΈƺPW

̿ɱ8ͶĐʃΥ TP18TP2 d`Ytpǻǁ̪jdǄżG̈ΙNwW9ULbǻǁ̪ęϪdˬʙȇ³b̿ŜRvL_G̅tw]Bv Taxol zʶĳPW_Lx8ͶĐʃΥ TP2 ˣɫdηͤͶĐGʸǂP
WL_Ft8TP2 dǻǁ̪ęϪͼКjd̿ŜG̋ūNwW9Tau ˣɫd°­zΐ΍RvL_^ǻǁ̪ęϪjdğƤǀĒbȘĲPW_BD8˚żeUdΘ̺a̿ŜȭĺΊɯ_ϴǈ¡¤̯Ƥdǻǁ̪ęǀ
ĒzΔm]Bv9

Figure 3. °­ΐ΍bƄ\Iǻǁ̪jdğƤęĿ

謝辞 ɦ̜̇e8̒GȝǈRvжŒƕƨƕƨЇǒƨ̜̇̔8ɭʰ̜̇Ʊ^͹ywlPW9ɭʰũĩȽȯathbƨ˟d˷ʂbȑΤ˥PÉKlR9lW8ĐȂ̩ȇ°­zMȵûBWXBWǼǎƕƨƕƨЇŃʏͳƨ̜̇Ϫdƕг̢Ƚȯ8ϱʚ̢Σǚ8athbºÆ¬¿ÄzMȵûBWXBWŁʲϟƕƨƕƨЇ˛ƨ̜̇ЇdôˢũǔȽȯ8ΉÜǱĝȽȯ8Arif Md. Rashedul Kabir ˑìĴȽbʴIǺ̌˥PÉK
lR9ɦ̜̇dÇϪeɄƨͺРƂ=ğƤÂ²~>dĴȘbsuƯɆNwlPW9
参考文献[1] (a) H. Inaba, N. J. M. Sanghamitra, K. Fujita, T. Sho, T. Kuchimaru, S. Kitagawa, S. Kizaka-Kondoh, T.
Ueno, Mol. Biosyst., 2015, 11, 3111–3118; (b) N. J. M. Sanghamitra, H. Inaba, F. Arisaka, D. O. Wang, S.
Kanamaru, S. Kitagawa, T. Ueno, Mol. Biosyst., 2014, 10, 2677–2683; (c) H. Inaba, N. J. M. Sanghamitra, T.
9

Fukai, T. Matsumoto, K. Nishijo, S. Kanamaru, F. Arisaka, S. Kitagawa, T. Ueno, Chem. Lett., 2014, 43, 1505–
1507.
[2] K. Matsuura, RSC Adv., 2014, 4, 2942–2953.
[3] M. Furutani, A. Uemura, A. Shigenaga, C. Komiya, A. Otaka, K. Matsuura, Chem. Commun., 2015, 51,
8020–8022.
[4] J. Katuri, X. Ma, M. M. Stanton, S. Sánchez, Acc. Chem. Res., 2017, 50, 2–11.
[5] (a) G. D. Bachand, E. D. Spoerke, M. J. Stevens, Biotechnol. Bioeng., 2015, 112, 1065–1073; (b) J. L.
Malcos, W. O. Hancock, Appl. Microbiol. Biotechnol., 2011, 90, 1–10.

10研究紹介	
  第 97 春季年会	
 優秀講演賞	 	 生物を意のままに操る“Chemogenetics”最前線	 	 京都大学大学院工学研究科	
  浜地研究室	
 
窪田	
  亮	
 
1. Ģ o b ș:dözʁȘRv̺͔e8ƒ˨FtdƓʂa¡ÀzœƴPƓʂaȂ̩z̋R9LCPW̺͔Ȃ̩zΊɯÅĦǺRvL_G^Hwf8İͳÅʢ˲b[aGvXJ^aI8=˟Ũ_e÷Fч>_BCɸʽ˶aŨУd̩Dz΄ĞTvŖ͕ȇGAv9PFPaGt8̺͔ębeÄ§ζq DNAÅRNA8͖ζ8èΤː_BZWϕɅpˉB̘ЦdŀŜːGƥżP]Eu8Ȃ̩bЁÌRvÄ§ζ(pPIeUdæd˟öğƤ)zĦǺÅΊɯRvL_eɤXŶГaΝУ_BDv9ϏǞ8˟öęƚБ˝ƋbEB]8ʃ˶Ä§ζdʬȇÅʇ͕zɕ̝Ѐ˶bĦǺ^HvɅʧΡGΊɯNw]HW9UCPWɅʧΡdÐ^p8ŀƨ˶Ȟʧ_ϤïƤǒƨz̽mŜyTW“chemogenetics (ŀƨϤïƨ)”e8ŀŜːGȫ[ʁϘƓʂȇ_ϤïƤǒƨGȫ[гBÄ§ζϣȤȇz˟FRL_^8˓ZWÄ§ζdmz̺͔ϣȤ˶b
ĦǺ^HvȞʧ_P]ʩ˻zАo]Bv 19ș:ḋ̜Ʊ^p8ŀƨ˶ȞʧdÐ^pϴǈϷöGȫ[ϭó ̿ Ŝ d ˑ ǽ z ˟ F P W ʬ ȇ ŀ Ȟ ʧ ^ A v “metallo-chemogenetics” z ̰ ı ˶ b Ͽ ˳ P ] B v 2 9Metallo-chemogenetics b[B]eɒǞɥd˟öʇ͕Ϫî¢ºÆÁÆ(2016 Ǟ 12 ɞ)bƶ̚PWWo8

ãųd=̜̻̇ä>^e8“chemogenetics”bEJvÍ˨ȌľzẴ˶bȮD[[8ș:ḋ̜d̠Yó͉qÄ­b[B]̻äPWB9_eч
2. “Chemogenetics”_

 ĪϑPWsCb chemogenetics e8ŀƨ˶Ȟʧ_ϤïƤǒƨz̽mŜyTʃ˶_RvÄ§ζdʬȇzĦǺRvɅʧΡ^Av9ŀŜː(ͳĬ)Gp[ŋķȇ_ϤïƤǒƨGp[гBʃ˶ˑ˫ȇbsu8̺͔ÅĺːĄöędƚБ˝ƋÊbEB]ɠmdµÄ^ʃ˶Ä§ζdʬȇz͜żĦǺ^Hv9lWÄ§ζ˳˚z̺͔ˑ˫˶­Â¸ÆÆ^ĦǺRvL_^8̺͔ϣȤ˶bʃ˶Ä§ζdʬȇĦǺRvL_pŖ͕^Av9Chemogenetics bEB]ʜˡNwvÄ­e8ƕHIÚ[bğЦ^
Hv9Ç[eϤïƤǒƨbsvϪóˑ˫˶Ɛ˫ǀĒbsu8ˑƮdŀŜːbƼP]Ä§ζʇ͕G
ON (pPIe OFF)bavsCazǀĒRvȞʧ^Au8Ú[˻eƄζ̿ŜbƐ˫ǀĒ
RvL_^Ƭēáǒ¿ÄbdmȂ̩RvÄ§ζzΐ΍RvȞʧ^Av9Ī͐dú_P]8

Stuart L. Schreiber tbsv Chemical inducers of dimerization (CID)GȭKtwv 39Schreiber te8ʃ˶Ä§ζb FKBP12 zƐ˫ǀĒPWͷŜÄ§ζzʁ̬P8FKBP12 bƼRvǭB¿Ä

^Av

FK506 zÚ[p[ğƤ(FK1012)zøˡNTvL_^8ͷŜÄ§ζzÚϳŀÅʬȇŀRvL_bȘ

ĲP]Bv9lWǶ͐dú_P]8Kevan Shokat tbsv Bump-and-hole GȭKtwv 49Shokat te8¡ÆdЄƳĬ̿Ŝ³bˈƐ˫zǀĒRvL_^8ϲ˟ſ_e̠öʁϘd˫av̿Ŝ³
zɟRvƐ˫ſ¡Æzʁ̬PW9LdƐ˫ſ¡Æe8áǒſЄƳĬbƼP]ϲ˟ſsup
400 ąǭB̿Ŝ͕z̋RL_GɎtF_au8¡ÆGĦǺRv̺͔ʇ͕dΘ̺ɽΎGŖ͕_aZW9
3. ̺ ͔ ͚ œ ƴ ö z á ǒ Ħ Ǻ R v W o d “chemogenetics”

 ĪϑPW chemogenetics dȞʧe8¿ÄøĺȇÄ¹£Àq G Ä§ζĕǲœƴö(Gprotein-coupled receptor: GPCR)̧d̺͔͚œƴöjdϢˡGÍ˨˶b˹{b͹ayw]Bv9̺͔͚œƴöe8̺͔ƒ¡À(̎̾ïϠːζ8±À¸Ä8ȘϽŴƤ)zœƴP8̺͔ęj¡ÀzïDvϱ΃aʇ͕zȧZ]Eu8ǖέdͳĬdŇɀGʃ˶bP]Bv_Nwv9̺͔͚œƴöbeɀƓId̘11Ц(¬«|µ¿ÆÅ¬­)GƥżP8UwtzͳĬ^ƬēbłĤRvL_e˚ż^pŶГ^Av9
LCPW͓ɗdp_8Í˨ḋ̜͐tG̺͔͚œƴöz˟̺͔Å͇̽ÅĺːĄöÁ¯À^ĦǺRv
chemogenetics zϿ˳P]HW9ãų8UdčwWȞʧ_P](i) DREADD, (ii) Optochemical genetics, (iii)

DART pharmacology b[B]ΊΜPWB9

 Brian Roth tGϿ˳PW DREADD (Designer Receptors Exclusively Activated by Designer Drugs)e8Īϑ

PW Bump-and-hole z class A GPCR bϢˡPWȞʧ_ȮDvL_G^Hv (Fig. 1a)9ǳte8¶¿Äȇ}À¿Äœƴö(mAChR)d¿Ä̿Ŝ³bƼP]8¾Ä¶Ɛ˫zǀĒPWƐ

˫ſœƴözøȘP8ϮʓzˡBW¿Æ¢Ä¶bsu8˟öębEB]Ëʬȇa CNO(clozapine-N-oxide)bȂ̩RvƐ˫ſ mAChR z˳΄RvL_bȘĲPW 59LdƐ˫ſ mAChR e8Ď:d}¢^Av}À¿ÄbeȂ̩TS8CNO ϣȤ˶bʬȇŀRvL_Gˑǽ^Av9Ld
ȇζbsu8˟ö˼Þ˶bƐ˫ſ mAChR dmzϣȤ˶bʬȇŀRvL_GŖ͕^Av9˚ż8DREADD
¶eƃЪ̺͔̳XJ^aI8͇̽qĺːĄöbEB] GPCR dÊʭ¡À(Gs, Gq, Gi/o)ϣȤ˶bïϠŖ͕aɅʧΡ_P]ǜǡIĥˡNw]Bv9lW Scott Sterson teŞʂdȞʧz¿Äøĺ6ȇÄ¹£ÀbϢˡRvL_bȘĲP]Bv 9
 Dirk Trauner te8Đbsu̺͔͚œƴödʬȇz ON/OFF Ŗ͕a Optochemical genetics _ŧfwvȞʧzȵɺP]Bv(Fig. 1b)79LdȞʧ^e8}¯ÄÄ-}¢΁Ŝöz¿Ä̿Ŝ³ϏĊbĕɟ̿Ŝ˶bǀĒPW̺͔͚œƴözΐ΍Rv9Ld}¢āЩœƴöe8}¯ÄÄd trans-cis Đ˫ȇŀbsu8}¢Ϫód¿Ä̿Ŝ³jd̿ŜÅ͗ВzĐ^ĦǺ^

Hv9LdȞʧe8̺͔͚œƴödʬȇzĐ^ĦǺ^HvL_Ft8ŀŜːdmzùˡRv
chemogenetics _ʕφP]8ɕ̝ЀğΊ͕Gčw]Bv9ǳte8optochemical genetics zÑb͞Ɵȇ̎̾ïϠːζœƴö^AvÄ¹£ÀſÀµÄϯœƴö(iGluR)ÅèΤſ(GPCR ſ)ÀµÄϯœƴöbϢˡP8͇̽athbĺːĄöbùˡP]Bv 7c,d9
 Ntbɿo]ɝϏ8Michael R. Tadross te DART (Drugs Acutely Restricted by Tethering) pharmacologyzȵŬPW 89DART ^e8̺͔ͼǉb HaloTag zǭĦ˳˚NTW(̎̾)̺͔bƼP]8HaloTag Ƅζzĕɟ̿Ŝ˶bϙ̿PW¿Ä(ЄƳĬ)zøˡNTvL_^8HaloTag _dĕɟ̿ŜzäP]̺͔ϣȤ˶b̺͔͚œƴödʬȇЄƳz͹CɅʧ^Av(Fig. 1c)9LdȞʧd·¿e8ʃ˶͚œƴödϞĮ˳˚zȀ΃_TS8ężȇ͚œƴödʇ͕ΊɯGŖ͕aˈ^Av9LdȞʧzˡBvL_^8ǳte§ÆÄÄ˯¸À´bEJvężȇ iGluR d̺͔ˑ˫˶aʇ͕ΊɯbȘĲP]Bv9

Fig. 1. 細胞膜受容体に対する代表的な chemogenetics.

4. ș : d } ­ Â Æ  ц “Metallo-chemogenetics”

 ɝϏș:e8̺͔ͼǉœƴöbƼRv chemogenetics dɄPB}­ÂÆ_P]8ϴǈÄÅϷö

bsvϭó̿ŜzʬˡPW“Metallo-chemogenetics (pPIe OcCC: On-cell Coordination Chemistry)”zȵ
ŬP]Bv9ϭó̿Ŝe8ædЙĕɟ̿Ŝ_ʕφP]ǭI8lWϴǈÐǿqϭóƤbsuǭǫz͜żĦǺ^Hv9lW chemogenetics bȂˡRvÉ^ʈFTaB·¿_P]8ʁϘΐ΍ȇdƴɏNGȭ

12

Ktwv9ϭó̿ŜeЙǛb̿ŜıGǭBWo8WZWÚɦdϭó̿ŜzÄRvXJ^ nM~µMd}«~¢~Æzȧÿ^Hv9lWœƴöĉdΐ΍ȇz͏Dv_8Ɩˋ}µ¤ϯbe His, Glu, Asp,
Cys, Met dϭóȇ}µ¤ϯʑƄGƥżP8ϤïƤǒƨbsuÇ}µ¤ϯʑƄÁ¯À^Ϫóˑ˫˶bϴǈϭóȇ}µ¤ϯʑƄzǀĒRvL_GŖ͕^Av9lWϏǞÇʘbľBzƌPW̺͔͚œƴödʁϘΊɯdȈȉ^8̠öʁϘzĳŦPaGtƐ˫ǀĒó͉z̰Ʒbΐ΍RvL_G^Hv9ș:e8L
CPW metallo-chemogenetics dˑǽzʬFRL_^8Ä¹£ÀſÅèΤſÀµÄϯœƴö(GluR)d}Â¿aʬȇŀbȘĲPW(Fig. 2)29Ėö˶be8ϴǈϷö_dϭó̿Ŝbsu GluRdʬȇŀʁϘzΚιÅƫƮŀRvL_^ GluR ʬȇzĦǺPW9LdȞʧdÄ§ζΐ΍eɿo]
Ä­À^Au8GluR d¿Ä̿Ŝd̿əʁϘΊɯzĎb8ʬȇŀɕbϏȲRv}µ¤ϯʑƄbƼP] His zˈƐ˫_P]Ú[ǀĒRvL_^8ʬȇŀʁϘɕbdmÁÆÚǥϭóƤ_P]ʇ

͕Rv9Ld His Ɛ˫ſ GluR e8Pd(bpy)(NO3)2 (bpy: 2,2’-©ª¿Ä)zʶĳRvL_^̺͔ęj¡ÀzïϠRvL_GŖ͕^Av9˚ż8ș:e8LdɅʧΡzƃЪ̺͔̎̾bȂˡP8His Ɛ˫ſGluR zʬȇŀRvL_^Êʭ¡ÀzθtTvL_bȘĲP]Bv9suΘ̺b[B]e8ɒǞɥd˟öʇ͕Ϫî¢ºÆÁÆzŎˌP]BWXJwfǟB^Av9
 lWϏǞ8ș:e metallo-chemogenetics dÄ­z class A GPCR bϢˡRvL_bȘĲPW 99

lXΘ̺eįȐNT]НIG8class A

GPCR _}¢d˽Ûøˡzϭó̿ŜbsuͿĴRvL_^8˓ZW
Ɛ˫ſ class A GPCR z˟̺͔bEB]ϣȤ˶bʬȇŀ^HW9˚ż8ș:eĪϑPWɅʧΡ_ĕbƚБa˟ö˝Ƌ^`Ll^ùˡ^HvdFb[
B]ʄ̹P]BvɝÐ^Av9

5. ̼ y u b

Fig. 2. Metallo-chemogenetics によるグルタミン酸受容体の活性化.

 Lwl^bϑk]HWsCb8chemogenetics e optogenetics _ĕbȆϗb˳ǇP]Bvȡͺ^Au8UwtzňŞ˶bĥˡRvL_^8ɤ̅av˟Ũ˚ΩdáǒĦǺGŖ͕_av_ɢǵP]Bv 109LdΏÙG8ϲɠʿwvƨ˟WYdˎȏbˆz[JvL_G^HWtǟB^Av9
Τϊ ɦ̜̇e8ßϬƕƨƕƨЇǒƨ̜̇̔ ʯŽɹȽȯḋ̜Ʊb]͹ywWpd^R9ɈОsuƓƕa

vMȻȸÅMĴΌzδulPWʯŽȽȯÅʷÐͩʅĝȽȯbȑΤ͝PlR9lWɈ:Ɠƕaĵız͂J]Bv(͂J]IwW)ʯŽ̇dƨ˟^Avϟ̭Ő̴ƤN{(˚ Ǚá)8ϲɩ͡I{(˚ ¥¿´ŀȘ)8ǁǎȔáI{(āƎ 2 Ǟ)8ǍЃȨЭI{(āƎ 1 Ǟ)bǺ̌˥PÉKlR9ŎˌɁ˖
1. (a) Islam, K. ACS Chem. Biol. 10, 343 (2015). (b) Zorn, J. A., Wells, J. A. Nature Chem. Biol. 6, 179 (2010). 2. Kiyonaka,S., Kubota, R., Hamachi, I. et al. Nature Chem. 8, 958 (2016). 3. (a) Spencer, D. M. et al. Science 262, 1019 (1993). (b) Peter

J. Belshaw. et al. Angew. Chem. Int. Ed. 34, 2129 (1995). 4. Bishop, A. C. Nature 407, 395 (2000). 5. (a) Bruchas, M. R.,

Roth, B. L. Trends Pharm. Sci. 37, 279 (2016). (b) Roth, B. L. Neuron 89, 683 (2016). (c) Armbruster, B. N. et al. Proc. Natl.

Acad. Sci. USA 104, 5163 (2007). (d) Vardy, E. et al. Neuron 86, 936 (2015). 6. Magnus, C. J. et al. Science 333, 1292
(2011). 7. Fehrentz, T. et al. Angew. Chem. Int. Ed. 50, 12156 (2011). (b) Volgraf, M. et al. Nature Chem. Biol. 2, 47 (2006).

(c) Levitz, J. et al. Nature Neurosci. 16, 507 (2013). (d) Caporale, N. et al. Mol. Ther. 19, 1212 (2011). 8. Shields, B. C. et al.
Science 356, eaaj2161 (2017). 9. Kubota, R. et al. Manuscript in preparation. 10. Jeong, J.-W. et al. Cell 162, 662 (2015).

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行事報告	 	
 第 10 回バイオ関連化学シンポジウム（金沢）開催報告	
 
	
 
	
  	
  	
  	
  	
  	
  	
  	
  	
  北陸先端科学技術大学院大学・先端科学技術研究科	
 
	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  	
  マテリアルサイエンス系	
  	
  	
 
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  昌宏	
 
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ßϬ>zşÔv=ēźßϬîΦ>z 2008 Ǟb͗îP]BlR9PFPŎĳNwW˷ʂpEʘ\H_ȅ
BlRG8˒ǑƕʆFtÉʭbŠFZ]́ovɗͤq8ͪǆͻdДŷʘe8ßϬb˞Ú[^R9PF
pʲdǟ8ǊdǟbȉlwWΨƸaЧɁŀ8ʺʥa`dΈĐŽ8Ntbe8ǝȘ 27 Ǟ 3 ɞdŁЉɄǠ
̈́Ͽɾ_8ƓIdɇ͹͐bȻȫNw]BváʘdΈĐŽ^pAulR9 Ä³¶dîƉe8ϴʠЮdÄ²ÀиϾsupϏB8p]aP

Æ¶8UP]ЮbЎȲRv̆Ǒ˾̠ЛʀƆzĥˡNT]НHlPW9ЮFtǷʎ 0 ğ8áʘdϴʠ_BC̠ŽdEЈpAu8Ɠ
IdŎĳ͐bȉlwлŎĳ͐ 430 ş8Ç͢ŔС˳ͼ 92 ë8³Æ234 ëм8ϙɈ8ʬ˳ȧ̜ʬĺd̻ä8UP]ˎǿa~¼ÄG͹ywlPW9 1 Ɉ˻e8Ç͢ĽАdŔСΣˁ,³ÆΣˁG͹ywlPW9ŁЉϴʠ_eΌD89 ɞdơoe8F
audͰPɚN^8ˑb̝ΞG͹HǅFaB=p]aPÆ¶>dîƉe8ˑbɚͧPFZW_ȅB

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PFPU{aÐ8ʬ˳a~¼ÄG͈uǡKtwWde8Ñċ͐_P]8ƣPBІu^PW9

2 Ɉ˻e8Ç͢dΣˁ8ȩǵΣˁ8UP]ȕ·îGċNwlPW9ãųe8¦ЁϙŀƨÄ³
¶_P]e8YrC`̥ 10 ų_BCΏȄdî^pAulPW9UL^ȩǵΣˁe8UwVwdϪîFtǺʬςÐd=ϱϻ>dď˟Ʌb8ǺΣˁzEХBPlPW9 ˟öʇ͕ЁϙŀƨϪîFte8ɧɦ˼ǔď˟лˤŉƕм=ɷϯdЙʃʾʁϘzʃ˶_PWďĦɷϯŃ
ǒƨ>8¦¤ÂÆϪîFte8ʗΧɵÇď˟лЃƕм=˫ğϲňƝbsv¦¤ÂÆdϛǇ-¦¤ÂÆϪî 20 Ǟz̾]->zǺȥЗP]НHlPW9=ͦBɅ:zĎʘ\J]Ê
NB9>_d̒FtdEХBbpȂD]НJW8ƕƐ̸ɘtPBǺΣˁ^PW9îƉdЛʀƆϨʀ±Æ
Àe8ʼŪd͑͸^PW9
ȩǵΣˁbǨH͂B]8ȕ·îz8ANA ¾Ä­¾±Àϴʠ^ϿċPlPW9ŽĎɂ˛pʀ
P{^НIWob8=ƽŚ>_=ĳαϲͬdƖit>dÆ¡ÆpΐJ]8˷N{bů{^НJWd^
eaBF_ȅBlR9ϪîΣˁεdͼǱ^e8̟ˢàʖ8ÐˢɵŚʖ8ʮʣƕ̍ʖ8ļˢЊäʖbεGȯÌNwlPW9ȕ·îǶp8ϴʠЮťϋ8AvBeШЧǣGτzϙcvˏ˦Ϗϋj_͈uĞP]8
UwVwb˷N{8ϴʠdƔzʀPlwWd^eaBF_ȅBlR93 Ɉ˻e8ņĪÐdŔС˳ͼdm
G͹ywlPW9ȕ·îd͍Ɉdɝ̼Ɉ_BCÙ^8Ŏĳ͐GǂaBd^eaBF_ȗȄNwlPW
G8ɝǶl^ƓIdŎĳ͐bȉlw8ˉÙ8ØƮϖud­Â¾¶z̼DvL_G^HlPW9 Ä³¶zˉÙbϿċ^HlPWdp8ϴʠƕƨ˛ǒ̜̇Ƃːζŀƨ̳Å̓ɸͩÒď˟8athḃ̜Ʊd˷ʂ8UP]8ŁЉḍ̌̔ƨȡͺƕƨЇƕƨÅ´¿}ÀÄ̳d«8ƕƨЇ˟d˷ʂFtdǺĴıdEЈ^R9lW8̆Ǒ˾8ϴʠǖ8ϴʠÄ¯Ä¼Ä©ºÆÂÆ8ňγíɾd˷ʂFtpƓƕavMȸĴzНțPlPW9LdƉzĆu]8Ě˥PÉKlR9ɟГCM
OBlPW9ʉųe82017 Ǟ 9 ɞ 7 Ɉъ9 ɈbɬßƕƨǪ˟¹Ä§b]ϿċNwvØƮ^R9

	
  	
  	
  	
  	
  	
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  盛 り 上 が っ た 懇 親 会 	 15

行事報告	 	
 第４回バイオ関連化学シンポジウム若手フォーラム開催報告	 北陸先端科学技術大学院大学・先端科学技術研究科	
 マテリアルサイエンス系	
 
山口拓実	
 
 ǝȘ 28 Ǟ 9 ɞ 6 Ɉ8úǞdsCb¦ЁϙŀƨÄ³¶dĪɈb8̥ 4 ų_avͦȞ«Æ
¾¶л̥ 31 ų˟öʇ͕ЁϙŀƨϪîͦȞ«Æ¾¶Ḁ̊ 4 ų¦¤ÂÆϪîͦȞ«Æ¾¶мzϿċPlPW9ɦ«Æ¾¶e8ƨ˟zŢoWͦȞ̜̇͐dĹǭdƉ^Av__pb8EÛBdÞ
ʭzʴovL_p˻˶dÇ[^R9ãų8ϴʠdŽbƨ˟ 64 şzŢn 100 şéÉdŎĳ͐GАlu8ŞÍèḋ̜͐dгB}~©~b˼b΋w]Þʭzʴov8lW_aBʇî_aulPW9 ȩǵΣˁdí˧bAWZ]e8ɖʒḋ̜ğϲ_e˫avÄzƨhWB_8˟öʇ͕ЁϙŀƨϪîͦȞdîÅ¦¤ÂÆϪîͦȞdîzÐǿ_PWÍΖáÇŞ^ȏ΄zĞPŜBlP
W9Ud̿ɱ8Ɠʂağϲ^ʬςNw]Bv 5 şdͦȞΣǚлǡǎǖƕÅĘɭõėŊƎ8̎ȜƨЇƕÅΉˢȒÇŊƎ8ЃƕÅʹˢđɍŊƎ8ğƤ̇Åʍǌϱ͹ŊƎ8ŁЉḍ̌ƕÅɭɩũɎŊƎмbsv8¦¾~bƸ{XΣˁzƯ˚RvL_G^HlPW9Σǚzȃ΢P8ƕƐеı˶aEΖzP]IXNZWď˟Ʌ8ɦǮbAuG_CMOBlPW9

参加者集合写真。多くの方に参加していただき盛会となりました。どうもありがとうございました。第 5 回バイオ関連化学シンポジウム若手フォーラムは小松	
 徹先生らの尽力のもと、2017 年 9 月 6 日、東京大学にて開催され
ます。	
 

	
 

16

 _Lx^8ɦ«Æ¾¶dîƉe8ϴʠdɄPBÄ²ÀdÇ[_aZ]BvϴʠЮ=иϾ>dÊ
bǡGv8p]aPÆ¶ŽÊ¯ÄǡƉzʬˡPWˑΐÆ^PW9ǮɈeōPBʑɚ_au8ʬʘAvΦΡp˽lZ]ˑΐîƉdʺǤe¨Æ}­RvfFu9PFP8U{aɚNbeΫ
JS8ȩǵΣˁq 60 ëpd³Æ˳ͼ^dϕĠwvL_aI͂IΦΡ8ȕΟî^d͛z̞HŜyT]dȏ΄Þȶ_8ƕƐa˹î_aulPW9ɦ«Æ¾¶zϖP]ƃywẆ̜qád£ÃÆe8ȁwGWBîƉdДŷʘ_AyT8Ŏĳ͐dЀbǭIĕɟNwWpd_ȅBlR9MȻȸzδu
lPWɈɦŀƨî˟öʇ͕ЁϙŀƨϪî8Ɉɦŀƨî¦¤ÂÆϪî8«ÂÄ~}˟Ũŀƨ̜̇î8±5ÅκğƤŀƨ̜̇î8ɄƨͺРƂ̜̇=ĺ˶̕Ǣ_ʇ͕>8Ĕ˸άŵʧáÄ¿Æ˟Ũ̔ƨάŵdmaNl8UP]·σb¦}­zP]IXNZWгɣɍƭď˟b8ϱ
c]Ǻ̌˥PÉKlR9 ɦ̚^e8̥ 10 ų¦ЁϙŀƨÄ³¶^d³Æεb[B]pǂP΋wNT]BWXH
lR9ͦȞdÄÁz˻ȬPW³ÆεdϝŰb[B]p8ÎϪîdͦȞ·Ä¦ÆGÐǿ_aZ]AWulPW9ƻɳƼΩ_aZW 89 ëd˳ͼeBSwp¥Á¯À^Au8ІtwWɕЀdÐ^˳ͼ͐_ζŭ͐_dЀbe˃PB~¼Äp͈uǡKtwWL__ȅBlR9Ud̿ɱ8

RSC εzŲžĸ̉N{8ãăȊίN{8č̑³ÆεzɭɦƕʅN{8̎Ď ƹN{8϶ɣȍǝN{8ɭÝĸχN{8ɻ˅ƿŘN{8гϲЊƤN{8гÝЬ͇N{GœεNwlPW9ȕ·î^dœεǧp˹uÉGu8˟öʇ͕Ёϙŀƨd˸:d˳ǇzØȑNTvpd_aulPW9

17

開催案内	
 生体機能関連化学部会第2回国際シンポジウム	 The 2nd International Symposium on Biofunctional Chemistry (ISBC2017)˟öʇ͕ЁϙŀƨϪî^e8фǞĪbϿċNwWϪîźЍîΦцISBC2012bǨH͂H8ÉΏdźЍîΦ(ISBC2017)zɦǞрсɞbϿċRvÙGǲŪî^ʞƮNwlPWd^8Mɺę˥PÉKlR9ɦϪîŪd˷ʂdMŎĳzʌώBWPlR9_uyJ8ͦȞFtÐƇǉdϪîŪdď˟Ʌ8Eshṥ̜ƱbMȝǈd³8ŊƎΝ̗ƨ˟a`dͦȞd˷ʂdŎĳ8˳ͼzɢǵP]EulR9`CVs

xPIEХBPlR9μ Ɋ ц˟öЁϙϪî˔͜dîŪÆ©8EshźЍÞʭýϛdÇ˝_P]8лрмϪîŪd˷ʂjğϲqźzλDW­Á¯ÀdÄq±ªb΋wvʇî   zȵûRv
лсмϪîŪ^AvŊƎΝ̗ƨ˟Ft³

8ͦȞ«лĴȽ8ĝȽȯмzÐǿbźЍ˶a­Á¯À̜̇͐_dΦΡdƉzȵûP8visibilitydŠÉzýϛRv9
лтмŎĳ͐Ѐd˽ÛÞʭq£ÃÆʁ̬dýϛbsZ]8Ϫîdáɨ͒Ș8ǮΗğϲd˳Ǉz
Ÿv9Ɉ ɕ цǝȘ29л2017мǞ12ɞ14лɣм@16ɈлŻмƉ ȝ цßϬƕƨƩʢ¹Ä§ HeX±ÆÀŎ ĳ ˴ ϸ ΰ цÇ͢ϪîŪ Ě ƨ˟ϪîŪ Ěȕ · î ΰ ц ĚлØƮм̽ ͇ Ƣ Ū Ͻ цÈŌ Òũлɬǒƕ ȽȯмƯ ͹ Ƣ Ū Ͻ цʯŽ ɹлßϬƕƨ Ƚȯм̽ ͇ Ƣ Ū ц2017Ǟ˟öʇ͕ЁϙŀƨϪîǲŪēŪ
îΦʁȘцх¼Äлʉ°ÆŎˌ8ś¼ÄтɕЀ̗ǤмцŔС˳ͼeȩǵΣˁdm8
Esh³Æ¼Äл2h̗ǤzсɈЀ8тɈЀȴ̋ØƮEsh³Æ˳ͼdshort introduction
л1min/1á̗Ǥмм9сɈ˻Ɣцȕ·îzØƮлȩǵмΣˁ͐¿ц   ¼ Ä ˪ ř ц 1. New Structure and Function of Bimolecular Systems
Session Organizerлèͼм: ÉϲȽȯʊ̮рцProf. Akif Tezcan (UCSD)ʊ̮сцProf. Sijbren Otto (University of Groningen)}}цProf. Jiangyun Wang (CAS)źęцɰ гŘ ď˟лЃƕмźęͦȞцǝǊ õ ď˟ (ǋЂͳƕİͳŀƨ)   ¼ Ä ˪ ř ц 2. Artificial Molecular Systems beyond Biological Functions

18

Session Organizerлèͼм: ϴŌȽȯʊ̮рцProf. Rein Ulijn, (Univ. Strathclyde, UK)ʊ̮сцProf. Jonathan Clayden (Univ. Bristol, UK)}}цProf. Vivian Wing-Wah (The University of Hong Kong, China)źęцʮʣ ʱÓ ď˟ (şŕǆƕƨ)źęͦȞцɗǊ ͌Ó ď˟лŁʲϟƕƨм   ¼ Ä ˪ ř ц 3. New Aspects of Biomolecules
Session Organizerлèͼм: ǦˢȽȯʊ̮рцProf. Todd O. Yeates (UCLA, USA)ʊ̮сцProf. Roland K. O. Sigel (University of Zurich, Switzerland)}}цProf. Xing Chen (Peking University, China)źęцʟ Ĉâ ď˟ (ǌǊƕƨ)źęͦȞцÐˢ ɵŚ ď˟лßϬƕƨм   ¼ Ä ˪ ř ц 4. Physical and Quantitative Understanding of Cells at Molecular Level
Session Organizerлèͼм: ÈƠȽȯ
ʊ̮рцProf. Evan Miller (UC Berkeley)ʊ̮сцProf. Gary Pielak (Univ. of North Carolina, Chapel Hill)}}цProf. Yan Jie (Natl Univ of Singapore)źęцɪǃ Ϊá ď˟лßϬƕƨмźęͦȞцϡʹ ˘ʅ ď˟ (ˤŉƕ FIBER)   ¼ Ä ˪ ř ц 5. Organic Chemistry in Cells
Session Organizerлèͼм: ʷÐĝȽȯʊ̮рцProf. Benjamin Davis (Oxford Univ)ʊ̮сцProf. Yimon Aye (Cornell Univ)}}цProf. Peng Chen (Peking Univ)źęцϴÝ ʛ ď˟ (ɬƕЇͳ)źęͦȞцͭŌ ñÕ ď˟лşƕЇ˛м   ¼ Ä ˪ ř ц 6. Chemistry for Cell Analysis and Regulation
Session Organizerлèͼм: ǊɬȽȯʊ̮рцProf. Jason Chin (MRC, UK)ʊ̮сцProf. Michael Z Lin (Stanford Univ, USA)
}}цProf. Hyun-Woo Rhee (UNIST, Korea)źęцôʹ ƪþ ď˟ (ɬßƕƨ)źęͦȞцƅ ЏÇϩ ď˟ (ƕЃƕƨ)
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 
	
 

19

	
 
	
 

20

	
 

21

開催案内	 	
 生体機能関連化学部会若手の会第２９回サマースクール	 Ñ ċ  Ɉɦŀƨî˟öʇ͕ЁϙŀƨϪîͦȞdîĕ ċ  ɈɦŀƨîнƄ̊ɟʇŀƨîň γ  ÐźЕıȡͺ̜̇άŵî ɢ  7 ɞ 10 Ɉлɞм13 ɕъ11 Ɉлˆм11 ɕ 50 ğî Ɖ  ɭʝ¢ºÆ}Æ¦Ä±Àлǎɸ˾ɭʝǖ΂ͪ˦ 40-1м
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Ŏ ĳ ˴ ϸ Ø ̵ ˥ ό ͅ Ġ  6 ɞ 9 Ɉлϴм˳ ͼ ǯ ǧ  ³ÆbsvÇ͢˳ͼzĽАPlR9lW8ƨ˟bsv˳ͼFtɀëz³Æε_P]ͼǱPlR9ȩ ǵ Σ ˁ л 50 Л П мрпʁϘzΊIŀƨFtʁϘ^ȨIŀƨjлŁƕЇǒм˕ˍʪͨсп^˝ƋzğɯRv ъb^HaBъл̐Ý˾ƕƨͺȽЪмƕ̆ŮЋтпDNA zWWn8Ⱥv8ùC9лɬƕЇǒмϽˢĈäупгķ˗aƓʒЌϮ̸őȂzƯ˚Rv DNA ¡¤¿}Ædİ΀лßƕ£̇мÐˢɵŚфпµÂ©Ädʇ͕ʁϘΊɯbŠJW®¶оÂ©Ä˽ÛøˡdğƤΐ΍лŅͮƕЇͳмɸ̄Èϩхп˟öğƤq˟̺͔zɨɂ_P]ʬˡRv¦ÄÄлǡƕЇḍ̌м͠ʆÒɗ˳ ͼ ˥ ό Ʌ ʧ  ÊΏ HP zŎˌØ ̚ Ō ̚  ÊΏ HP zŎˌŎ ĳ ˴ ϸ ΰ  Ç͢ 10,000 Ěнƨ˟ 3,000 Ě9΃ɊАèнƵʦɡɔƑЧÙèнȕ·îΰŢn9ȕ · î  7 ɞ 10 Ɉлɞм19 ɕŇ@9îΰˉɂŎ ĳ ˴ ϸ Ø ̵ ˥ ό Ʌ ʧ  ÊΏ HP zŎˌ˥ ό ďÅŭ Ŝ ď  690-8504 ǎɸ˾ɭʝǖ΂Ǒʫ˦ 1060 ǎɸƕƨƕƨЇ̓Ŝ˛ǒƨ̜̇̔ːζŀƨРƂɟʇŀƨр̜̇Ʊ ϶ɣč̢ ЕΖ 0852-32-6417
E-mail: m-suzuki@riko.shimane-u.ac.jp
HP: http://www.ipc.shimane-u.ac.jp/ss29/

	
 

22

開催案内	 	
 第５回バイオ関連化学シンポジウム若手フォーラム	 （第３２回生体機能関連化学部会若手フォーラム・	 	  第５回バイオテクノロジー部会若手フォーラム）	
  ˟öʇ͕ЁϙŀƨϪîͦȞdî8¦¤ÂÆϪîͦȞdî^e8ɬßƕƨ^ϿċNwlR̥ррų¦ЁϙŀƨÄ³¶dĪɈb=ͦȞ«Æ¾¶>zϿċPlR9¦ЁϙŀƨdğϲbEB]̥Ç̈́^MʬςNw]Bvхşdď˟ɅbMΣˁBWXIØƮ^R9lW8³ 8ƨ˟a`ͦȞ̜̇͐d˳ͼ8ÞʭdƉ_P]8³Æ¼Ä_ȕ·îz͹BlR9«ÂÄ~}˟Ũŀƨ̜̇î8±5ÅκğƤŀƨ̜̇îdɅ:Ftp8ǡI˳ͼzĽА͝PlR9Ld«Æ¾¶zʇbͦȞ̜̇͐Eshƨ˟dɅ:dħ˃zǹvWobɓЙ_pƏzFJ]НHŎĳzýP]НJlPWtǟB^R9
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招待講演者ʮÝ̏ţлɬßƕƨм8ƫʀʪƦлɬßƕƨм8ǁǊę ǏлɎʢƕƨм8Ōϲǟʢлɬßƕƨм8ʹɲþưлɋ̙ˢƕƨм8ǗɆɄÇϩлɬßǒɾƕƨм350 ЛП8ȿ̖˩

参 加 お よ び 発 表 申 込 方 法 （ ポ ス タ ー 発 表 ） 	
 ц http://www.skn.bio.titech.ac.jp/bio-wakate2017/
Websiteц˥ ό ď ц bio-wakate2017@bio.titech.ac.jp
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問 い 合 わ せ 先 	 ?113-0033 ɬßϬɁßłɦϫ 7-3-1

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23

開催案内	
 	
 第１１回バイオ関連化学シンポジウム	 （第３２回生体機能関連化学シンポジウム、	
 
	
  	
  	
  	
  	
  	
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24

参加および発表申込方法	
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参加登録費	
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問い合わせ先	 ϙ̀ď: ̥ 11 ų¦ЁϙŀƨÄ³¶ÙĻǄ

Tel:03-5841-8902, E-mail: bio11@chembio.t.u-tokyo.ac.jp

25

お知らせ	
 	
 日本化学会第９７春季年会	
  優秀講演賞（学術）•学生講演賞	
 MœεEo^_CMOBlRč̑ΣˁεлƨͺмжŒƕƨƕƨЇǒƨ̜̇̔°­ ¡¤«|¦ÆdĐΚιȘϽzĥˡPWθĐȇ¿³Æ¶dʁ̬

RODE
Ambadas B.

ˤŉƕƨ

Frontier Institute for
BiomolecularEngineering Research(FIBER)

Nucleic Acids Chemistry beyond the Watson-Crick Double
Helix (28): A non-coding tRNA regulates functionally importantG-quadruplex-hairpin conformational equilibria in RNAϡʹ ˜ǔɬßƕƨƕƨЇ˛ƨ̳̜̇̔

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26ȣöbsvȣŌ°­ŜȘʧdϿ˳ŜȘʧd

ΙΥʇʁdˎıƨ˶ΊÀd̺͔νƉɨ

お知らせ	 	
 平成２９年度	  生体機能関連化学部会役員	
 

【部会長】
浜地

格 (京大院工)【副部会長】
浅沼浩之 (名大院工)伊東忍 (阪大院工)和田

健彦 (東北大多元研)

青木伸 (東理大薬)居城

邦治 (北大電子研)

井原敏博 (熊本大院自然)上野

隆史 (東工大院生命理工)浦野泰照 (東大院薬)

【幹事】

王子田

彰夫 (九大院薬)大槻

高史 (岡山大院自然)小澤

岳昌 (東大院理)山東

信介 (東大院工)島本

啓子 (サントリー生命科学財団)

高木昌宏 (北陸先端大マテリアル)

築地真也 (名工大材料科学フロンティア)

廣田

俊 (奈良先端大物質創成)藤井浩 (奈良女子大院自然科学)深瀬

浩一 (阪大院理)本間

実咲 (武田薬品)村上裕 (名大院工)水上

進 (東北大多元研)

竹澤悠典 (東大院理・若手の会代表)

鍋島

達弥 (筑波大数理)三原

久和 (東工大院生命理工)

【監査】

27

平成２９年度	
  生体機能関連化学部会若手の会支部幹事	
 	
 【北海道・東北支部】
三友秀之 (北大電子研)

高岡洋輔 (東北大院理)【関東支部】竹澤悠典 (東大院理)※ 若手の会代表幹事

安部聡 (東工大生命理工学院)

小松

徹 (東大院薬)【東海支部】
久松

洋介 (名市大院薬)愛場

雄一郎 (名大院理)【関西支部】大洞

光司 (阪大院工)多幾山

敬 (塩野義製薬)

柴田知範 （阪大産研）【中国・四国支部】
鈴木優章 (島根大院総合理工)杉川幸太 (広島大院工)【九州支部】
内之宮
石塚

祥平 (九大院薬)匠 (宮崎大医学)28

ニュースレター	  	
 Vol.32,	
 No.1

2017Ǟ6ɞ19Ɉ˳͹ÙĻǄц101-8307 ɬßϬŅèˢł̎ˢаʡŗ1-5, Ɉɦŀƨî˟öʇ͕ЁϙŀƨϪî
Office of the Secretary : The Chemical Society of Japan, 1-5 Kanda-Surugadai, Chiyodaku, Tokyo 101-8307, Japan
URL: http://seitai.chemistry.or.jp/

mail to: seitai@chemistry.or.jp͆АƢŪц˙Ƥˢ ǱƘ8ʰϲ ʪˌ8Ǌɬ Āä

29