MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

EFFECTS OF THORON SPA OR BATH
ON CANCER PATIENTS〇Atsuhiro Kishimoto, Kimiko Horiuchi, Koji Yamamoto

Healthypeople Co.,Ltd.
SPA-THORON Co.,Ltd.

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Introduction of Our Spa, Medical Spathoron Hanamaki
Hanamaki, Iwate
prefecture (Tohoku area)• Our facility, Medical Spathoron Hanamaki, is an artificial hotspring containg thoron, a radioactive material.
• Most of visitors are intended to improve their health in ourartificial thoron hot spring.

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

What is thoron?
Thoron is an isotope of radon.
Radon (222Rn) is a memberof the 238U decay chain andis the α decay product of226Ra.
Thoron （220Rn） is a memberof the 232Th decay chain andis the α decay product of224Ra.

238U

232Th

226Ra

224Ra

222Rn

206Pb

Half life of 3.8 d

Stable Pb

220Rn

Half life of 55.6 s

208Pb

Stable Pb

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Comparison of the thoron and the radon hot spring
item＼Radon hot spring
The half-life of radon is about 3.8① Radioactive material days, and it requires more than 20years until it becomes stable 206Pb.

② Hot water③ Location

Thoron hot spring
The half-life of thoron is about 55.6
seconds, and it requires around 11

hours until it becomes stable 208Pb.
To prepare hot water artificially, it is easy
Because of natural hot water, it isto obtain the radioactive effects stably
difficult to maintain the radioactive
and to investigate various conditions
effects and to study more effective
such as the thoron concenration and theconditions.
component of hot water.
It is difficult to move the place of spa It is easy to build the spa facilities in thefacility because of the natural hot
various places because of the artificial
spring.
hot spring.

The thoron hot spring is useful as the radioactive spring.

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Preparation of thoron hot water

The thoron hot water was prepared using our devices based on the weak acidleaching method.
1. The sand that contains thorium and organic acid allowed to act for 9 hours in ourproduction equipment to prepare the stock solution of thoron.
2. The stock solution was immediately injected into the tub in a certain dilution. This
operation was 4 times a day (6:00, 10:00, 15:00 and 19:00).

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Radioactive component of thoron hot water
METHODS: A stock solution immediately after thoron preparation was measured byliquid scintillation counter. The values of 220Rn were estimated from the value of 224Ra.
The following shows the table and graph.
Elapsed time（h） 228Ra (bq/l)

0
0.24
2.4
4.0

7.43
7.43
7.43
7.43

228

224

Ac (bq/l)

Ra (bq/l)

00.191.76
2.74

220

Rn (bq/l) Total radioactivity (Bq/l)

9.70
9.68
9.52
9.39

0
9.68
9.52
9.39

17.13
26.78
28.23
28.95

Radioactivity concentration（Bq/l)

100

total radioactivity
220Rn10Ra

224

228Ra
228Ac

1

0.1

0.01

0

1

2

3

4

56

7

elapsed time（ｈ）

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Bathing procedure in the thoron hot spring①
Put hand and foot destination in thebathtub, 3 to 10 minutes＊38 to 42℃②3 to 5 minutes in the state of sitz bath③

Soak up the shoulder, 1 to 2 minutes

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-1
Diagnosis： undifferentiated carcinoma of thyroid
Sex： male
Age： 68 years oldProgress：He was diagnosed with undifferentiated carcinoma of thyroid in June 19,
2014, and the surgery to remove the entire tumor was performed in thesame year on August 8. The taxol treatment (130 mg/body) was started
from September 16 of the same year. Bathing in the thoron hot spring(every day, 6 to 8 times a day, and bathing of each 10 minutes) began justbefore the second taxol treatment.
Effect： Reduction of harmful side effects of anti-cancer drug
diagnosis surgery 1st taxol 2nd・・・・・・

Bathing
1/20148/20149/201411th

no harmful sideeffects

12/2014

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Case-1
Standard taxol treatment【Dosage and Usage】
The schedule is to give 210 mg/m2 of taxol by intravenous drip infusion, followed bywithdrawal from medication for at least 3 weeks. Repeating this administration.
1st taxol

Withdrawal of 3 weeks
Alternatively, another is to give 100 mg/m2 of taxol by intravenous drip infusion once aweek for six consecutive weeks, followed by withdrawal from medication for at least twoweeks. Repeating this administration.
1st taxol

2nd1 week

3rd1 week

4th
1 week5th
1 week6th
1 weekWithdrawal of 2 weeks

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-1

Side effect
Peripheral neuropathy
was not observed.

start of bathing
decrease in white blood cells

taxol treatment
normal range

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-2
Diagnosis： renal cell cancer
Sex： male
Age： 66 years oldProgress： He was diagnosed with renal cell cancer in March
6, 2014. The sutent treatment (37.5 mg/body) wasstarted from March 19 of the same year for two
consecutive weeks.
Effect： Reduction of harmful side effects of anti-cancer drug
diagnosis

1st sutent

2nd sutent

Bathing of
1st week
3/2014

Bathing of
2nd week

no harmful side effects

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-2

Sutent treatment of the first week (bathing number of high-frequency)
Sutent treatment of the second week (bathing number of low-frequency)

normal range

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-3
Diagnosis：prostate cancer
Sex： male
Age： 68 years oldProgress： He was diagnosed with prostate cancer in August 2000. The rapid
rise in PSA, a prostate cancer marker was observed in December
11, 2014. In addition, bone metastasis was observed. Bathing inthe thoron hot spring (every day, 6 to 8 times a day, and bathingof each 10 minutes) began from January 10, 2015.
Effect： Tumor suppresion
diagnosis

PSA↑, ALP↑

PSA↓, ALP ↓Tumor suppression

Bathing
4/200012/20141/2015

3/2015Now

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-3start of bathingpause of bathing
resumption of bathing
normal range

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-4
Diagnosis： pleural mesothelioma
Sex： male
Age： 67 years oldProgress： He was diagnosed with pleural mesothelioma in February 2014.
Bathing in the thoron hot spring (every day, 6 to 8 times a day ,and bathing of each 10 minutes) began from December 12, 2014.
Effect： Tumor suppresion
diagnosis

no progression

no progression

Bathing
2/2014

12/201412/2015

Now

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Case-414.03.28

14.06.02

14.10.01

15.04.08

He was diagnosed that his cancer progression was almost stopped.

start of bathing
normal range

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

Other cases• A gallbladder cancer patient– 64 years old, male
– Decrease of tumor marker CEA and CA19-9 value was observed after bathing.

• A oropharyngeal cancer patient– 55 years old, male
– Skin damage with radiation therapy has been significantly improved.
• OthersMEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

SummaryCases

Effects of thoron hot water①②

・The bone marrow activity recovered after bathing.
・Peripheral neuropathy by taxol was not observed.
・It was able to perform 10-week continuous administration of taxol.

③④

・Tumor marker level decreased or was restored to the normal range.
・Progression of cancer was suppressed.

Conclusions
1. It was suggested that the thoron hot spring possibly
reduced the side effect of the anticancer drugs.
2. It was suggested that the thoron hot spring possibly had
the antitumor function.

MEDICAL SPATHORON HANAMAKISPA-THORON Co,.LTD.

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Healthypeople Co.,Ltd.
SPA-THORON Co.,Ltd.
Merino Rikugi-en building 4F, 1-3-1 Komagome,
Toshima-ku, Tokyo 170-0003, Japan
TEL: +81-03-3943-9070
FAX: +81-03-3944-4548
E-mail: matsumura@tron.ne.jp
URL: http://spathoron.jp/