Collaborating Centres
ANNUAL REPORT
Folder eCC_00015745 is in stage Annual_Report_Due
Name of the University, Hospital, Research Institute, Academy or Ministry
National Center for Global Health and Medicine
Name of the Division, Department, Unit, Section or Area
Disease Control and Prevention Center, National Center for Global Health and Medicine Hospital
Reference Number

JPN-94

City

Shinjuku-ku

Title

WHO Collaborating Centre for Prevention, Preparedness and Response to Emerging
Infectious Diseases

Report Year04-2018 to 04-2019

1. Annual report on the agreed workplan
Describe progress made on the agreed workplan. For each activity, detail (1) the actions taken, (2) theoutputs delivered, as well as (3) any difficulties that may have been encountered. Three responses areexpected. [maximum 200 words per activity]. Indicate, if an activity has been completed previously,
has not yet started or has been placed on hold.
Activity 1
Title: To provide policy and technical advice to WHO and Member States in implementation of APSED
Description: The proposed institution will provide technical advice on the planning and implementation of IPC
and clinical management components (Focus Area 5: Prevention through Healthcare) of the Asia PacificStrategy for Emerging Diseases and Public Health Emergencies (APSED III) via APSED Technical Advisory
Group (TAG) meeting, regional consultations/meetings and country visits.
Status: ongoing
Dr. Masahiro ISHIKANE attended the Meeting of the Bi-regional Technical Advisory Group on the Asia Pacific
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the IHR (2005) at the request of the WHO (June 19-21, 2018, New Delhi, India). At the meeting, he provided
technical advice on the planning and implementation of infection prevention and control (IPC) and clinicalmanagement components.
Dr. Satoshi KUTSUNA and Dr. Shinichiro MORIOKA participated in the 2018 Tranquil Terminus Full-Scale
Exercise, a national-wide transfer exercise of Ebola virus disease patients in U.S.A. (11-12 April 2018), andvisited Emergency Operation Center, CDC, Atlanta in order to discuss necessary measures on preparednessfor emerging and reemerging diseases (21 May 2018), upon request from Ministry of Health, Labour andWelfare (MHLW), Japan.
Dr. Satoshi KUTSUNA participated in training on CDC's pandemic influenza (11-15 September 2018), anddiscussed with the relevant parties on the actual response, and shared information on Japan's situation.
Activity 2

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Title: To provide in-country training and technical advice on infection prevention and control (IPC) and clinicalmanagement of emerging infectious diseases (EIDs)
Description: The proposed institution will provide training and technical advice on IPC or clinical managementof emerging infectious disease such as EVD, MERS, Dengue fever and Zika virus disease and antimicrobial
resistant infections, in collaboration with WHO, National Institute of Infectious Diseases in Japan (NIID) andspecialist from Asia Pacific Region, via in-country visits and on-line meetings. Through this activity, NCGM willcontribute to strengthen IPC or clinical management of emerging infectious disease as a major component of
national preparedness in the region.
Status: ongoing
Dr. Satoshi KUTSUNA participated as a short-term consultant to strengthen IPC and Antimicrobial
Stewardship (ASP) in partnership with the Japan International Cooperation Agency (JICA) at Cho Ray
Hospital, Ho Chi Minh City, Vietnam (May 9-18, 2018, and March 10-18, 2019). He gave lectures and provided
advice on IPC, clinical management of infections caused by carbapenem-resistant Enterobacteriaceae (CRE),and ASP. He will engage again as a short-term consultant in 2019 to provide follow-up and advance therelevant capacities.
Dr. Sho SAITO, Dr. Satoshi KUTSUNA, and Dr. Masahiro ISHIKANE provided oral care training for all nurses
at general intensive care units (ICUs) of Cho Ray Hospital, Ho Chi Minh City, Vietnam, to reduce ventilatorassociated pneumonia due to AMR. They developed new oral care training guidelines for use in resourcelimited settings. The guidelines will integrate the Cho Ray Hospital nursing textbook.
In addition, Dr. Saho TAKAYA and Dr. Masahiro Ishikane reviewed and advised the National infection
prevention and control policy in PNG (third edition) requested on WPRO.
Activity 3Title: To participate in monitoring and assessments of in-country capacity in relation to IHR core capacities
through APSED
Description: The proposed institution will participate in the monitoring and evaluation activities of IHR
implementation, including the areas of IPC and clinical management component, upon request from the WHO.
Status: ongoing
The Asia-Pacific Economic Cooperation (APEC) forum occurred in Port Moresby, Papua New Guinea, inNovember 2018. The National Department of Health of Papua New Guinea held a four-day workshop on IPC
in July 2018, in which the Disease Control and Prevention Center (DCC) at the National Center for Global
Health and Medicine provided technical advice with WPRO. This workshop was designed to increase
understanding of basic IPC operations and practices, as well as to help participants develop action plansbased on IPC assessments conducted at each hospital. Workshop participants shared their knowledge, goodpractices, challenges, and lessons learned from their work and experience in IPC. The workshop was also anetworking opportunity for hospitals for capacity development and monitoring and evaluation for improvementof IPC during and after the APEC. The report was published on the WPRO website炷https://www.who.int/westernpacific/news/feature-stories/detail/who-strengthens-collaboration-for-infectionprevention-and-control-in-the-region?fbclid=IwAR1OkcEMkzJO14W3-t-gQGHsg8izuLE71jjJ71xSyhWGXkAsUtoXkOmiBw炸įAt the request of WPRO, Dr. Yoshiaki GU participated in the Informal Consultation on Strengthening
Antimicrobial Resistance Surveillance in the Western Pacific Region as a consultant (April 23-25, 2019,
WPRO conference room in Manila, the Philippines). Consultants and participants from member states
discussed the current situation for improved AMR surveillance, including systems, training, coordination, andinternational support.
Activity 4

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Title: To share information and knowledge on best practices of IPC and clinical management of EIDs
Description: NCGM plans to collect and share best practices of IPC and clinical management of emerging
infectious diseases including antimicrobial resistant infections with health care professionals via workshops
and seminars at NCGM.
NCGM will share information of best practices of IPC and clinical management through e-learning and other
online channels.
Status: ongoing
The DCC developed guidelines on IPC and clinical management of AMR in English for resource-limited
countries, and shared these documents through the DCC website(http://dcc.ncgm.go.jp/activity/Other_activities/2018/2018.html). These documents were divided into handhygiene, IPC, AMR global situation and strategy, management of outbreaks in health facilities, experience andlessons sharing such as IPC in the occurrence and control of measles, outbreak simulation exercise on IPC,and IPC assessment framework. The DCC can also provide a four-day IPC workshop in limited-resource andunderdeveloped-infrastructure settings upon request.
Activity 5Title: To provide technical support in the investigation of EID outbreaks
Description: The proposed institute will provide technical supports in the investigation of emerging infectious
diseases including AMR, upon request from WHO.
Status: ongoing
Dr. Masahiro ISHIKANE conducted an investigation of the Zika and measles outbreaks in Brazil, Cuba, andVenezuela, at the request of the Ministry of Foreign Affairs of Japan (November 5-16, 2018). He discussed theproblem of epidemics in Venezuela with Dr. Malhi Cho, Advisor in Health Systems and Services at the Pan
American Health Organization (PAHO), WHO.
Dr. Satoshi KUTSUNA conducted an investigation of the Crimean-Congo hemorrhagic fever (CCHF) in Turkey
at the request of the Ministry of Health, Labour and Welfare (MHLW) of Japan (April 15-18, 2019). He visited
the Ankara Yildirim Beyazit University, the Ankara Training and Research Hospital, and the Ministry of Health.
He also discussed and gave a lecture on IPC and clinical management of CCHF to the local doctor.
Activity 6Title: As part of outbreak response, to provide technical assistance in improving IPC and clinical managementof EIDs
Description: The proposed institute will provide on-site or remote technical assistance or training in improving
IPC and clinical management of emerging infectious diseases including AMR, upon request from WHO.
Status: ongoing
The DCC provided personal protective equipment (PPE) to Cho Ray Hospital in Ho Chi Minh City, Vietnam, toprepare for ICP against emerging infectious diseases (EIDs). The infection control team at Cho Ray Hospitalis preparing to set up a system against EIDs in the hospital, referring to the provided PPE. The DCC also
provided information on how to attach and remove PPE and support training for Ebola and avian influenza
response by the infection control team at Cho Ray Hospital.
As a part of remote technical assistance or training to improve IPC and clinical management of EID and AMR,
the activities of the DCC were published on the website of the Strategic Partnership for International HealthRegulations (2005) and Health Security (SPH), at the request of the WHO headquarters (HQ)
(https://extranet.who.int/sph/donor-partner-landscape). The DCC operates in the fields of AMR, immunization,
emergency preparedness, emergency response operations, and medical countermeasures and personnel
deployment.
Dr. Satoshi KUSUNA visited Liverpool School of Tropical Medicine (LSTM) on April 1-4, 2019, and discussed
the joint clinical research of CCHF in Turkey. He shared information on the epidemiology and treatment ofSevere Fever with Thrombocytopenia Syndrome (SFTS) in Japan.

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2. Annual report on other activities requested
Should WHO have requested activities in addition to the agreed workplan, please describe related
actions taken by your institution [maximum 200 words]. Please do not include in this report any
activity done by your institution thatwas not requested by and agreed with WHO.
At the request of WPRO, Dr. Masahiro ISHIKANE participated as an observer in the Guidelines Development
Committee Meeting, which aimed at updating the WHO standard guidelines for the clinical management ofinfluenza infections (March 25-27, 2019, Geneva, Switzerland). The guidelines should be shared in 2019.
Also, at the request of WPRO, the DCC advised on the components of pediatric anti-influenzas drugs and on
the preparation for influenza outbreaks in resource-limited settings. In addition, Dr. Shinya TUSZUKI, Dr.
Nobuaki MATSUNAGA, and Dr. Masahiro ISHIKANE conducted a literature review on the implications of AMR
in secondary infection during influenza pandemics in resource-limited countries.
At the request of HQ, Dr. Yoshiki KUSAMA reviewed and summarized the situation of the antimicrobial
development pipelines and pre-pipelines in Japan. He discussed the issue with Dr. Sarah Paulin, Technical
Officer, Innovation, Access and Use, Essential Medicines and Health Products, Medicines, Vaccines andPharmaceuticals at WHO-HQ.
Ah the request of the MHLW of Japan and HQ, Dr. Mugen UJIE attended the Integrating Research into
Response workshop (May 1-2, 2018, Geneva, Switzerland). He discussed current initiatives and future
directions for bringing out outbreak response research with over 90 participants from 56 GOARN member
institutions, from several WHO regions and nine WHO departments.

3. Resources
Indicate staff time spent on the implementation of activities agreed with WHO (i.e. those mentioned inquestions no. 1 and no. 2 above). Do not include any data related to other activities done by yourinstitution without the agreement of WHO. Please indicate staff time using the number of “full-dayequivalents” – a day of work comprising 8 hours (e.g. 4 hours work per day for 7 days should berecorded as 3.5 full-day equivalents).
Number of staff involved (either partially or fully)
Senior staff

Mid-career staff

Junior staff, PhD students

4100

Number of full-day equivalents, total for all staff involved
Senior staff

Mid-career staff

Junior staff, PhD students

740

Implementation of the agreed workplan activities (i.e. those mentioned in questions no. 1 and no. 2above) normally require resources beyond staff-time, such as the use of laboratory facilities,
purchasing of materials, travel, etc. Please estimate the costs of these other resources as apercentage of the total costs incurred (e.g. if you incurred costs of USD 100 and the value of your staff
time was USD 50 which makes the total of USD 150, please report 33.3% and 66.7%).
Percentage of costs
associated with staff time

Percentage of costs associated with Totalother resources

25.00

75.00

100.004. Networking
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Describe any interactions or collaboration with other WHO Collaborating Centres in the context of theimplementation of the agreed activities If you are part of a network of WHO Collaborating Centres,
please also mention the name of the network and describe your involvement in that network[maximum 200 words].
Dr. Masahiro ISHIKANE participated in the second Japanese WHO Collaborating Centers meeting (April 14,2018, Tokyo), which was also attended by Dr. Takeshi Kasai, Director of Program Management, and Dr.
Tomohiko Makino, Medical Officer, Program Management, Country Support Unit, WHO/WPRO. Thirty-one
WHO Collaborating Centers in Japan participated in the meeting. We discussed and made recommendations
toward the third Regional Forum of WHO Collaborating Centers in the Western Pacific (November 22-23,2018) as a WHO Collaborating Center in Japan.
Dr. Masahiro ISHIKANE participated in the third Regional Forum of WHO Collaborating Centers in theWestern Pacific (November 22-23, 2018, Ho Chi Minh City, Vietnam). At the meeting, he discussed themechanism of sharing timely and local needs between WPRO, WHOCC, and the Ministry of Health MOH
based on the APSED III. He also shared the experience at the IPC workshop in Papua New Guinea andcollaborated with WPRO and the Papua New Guinea MOH, as one of the good models.
The DCC plans to implement the GOARN training course in Japan in 2019, thus collaborating with HQ,WPRO, MHLW of Japan, and other WHOCCs in Japan.

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