関西医科大学̲海外版̲入試ガイドA案

Research
Fields2024

Research Field : Functional Morphology and Regenerative Biology(Department : Anatomy)

Professor

Masaaki Kitada【Research Fields】
1. Researches focusing on regeneration of damaged tissues using regeneration-competent animals that achieve functional
reconstruction by spontaneous regeneration (Kitada, Hayashi, Seki, and Nakano)1. While the tissue regeneration ability of mammals is limited, “regeneration-competent animals” such as fish and amphibians
exhibit spontaneous regeneration after tissue damage to achieve functional reconstruction. We are studying the mechanism of
spontaneous regeneration in regeneration-competent animals in anticipation of its future application to humans.
2. Neurogenesis by cell fate manipulation (Kitada, Hayashi, and Nakano)
1. Our research aims to create new nerve cells at the sites, where they are needed, by artificially regulating the cell fates of native
stem and progenitor cells, which will be beneficial for the treatment of neurodegenerative diseases and damages of neural tissue.
3. Dynamics and functional analysis of glycolipids in neural development (Hirahara)
1. We analyze the role of glycolipids in the development and disease of tissues, focusing on the nervous system, with the use of avariety of research techniques, particularly imaging mass spectrometry.
4. Functional analysis and therapeutic research on the genes expressed in glioma (Oe)
1. Our research focuses on microRNA and long non-coding RNA, which are specifically expressed in cancer stem cells, toward thedevelopment of new treatments for glioblastoma, which is the most malignant brain tumor.
5. Functional analysis of novel nerve cells in dorsal root ganglion (Koike)
1. The dorsal root ganglion (DRG) is comprised of neurons (ganglion cells) and Schwann cells of the peripheral nervous system. We
have been exploratoring the functino of a novel subtype of ganglon cells and novel glial cells present in DRG.
【Attainment goals】
1. Understanding the previous reports and backgrounds of a topic and learning applicable methodologies to contribute to the theme.
2. Learning the basic morphological and functional aspects of target organs and target stem/progenitor cells.
3. Independently flormulating the research plan, performing the experiments, and developing the research.
4. Mastering morphological methods and their theories and developimg the ability to correctly interpret experimental results.
5. Summarizing research results, making the oral presentation, and reporting them as a paper.
6. Taking in the opinions of others and flexibly responding in conducting research.

Research Field : Cognitive Neuroscience(Department : Physiology)

Professor

Kae Nakamura【Research Fields】
Our laboratory aims to elucidate the neurological substrates of cognitive functions and behaviors. In neuroscience, in addition to
studying function at the genetic, molecular, and cellular levels, we must clarify how these parts function as a circuit, connecting
to real behaviors. To this end, we utilize electrophysiological and pharmacological approaches, as well as computational analysis
in primates performing rigorously planned behavioral tasks. Furthermore, our laboratory incorporates optogenetic techniques, a
rapidly developing technique in rodent models. Currently, we are exploring (1) the decision-making mechanism based on reward,
punishment, stress; and risk information and the roles of neurotransmitters, such as dopamine and serotonin, and (2) the neuralmechanism of social emotional information processing. We are also conducting joint research with clinical departments, such as
the Departments of Rehabilitation and Pediatrics.
【Research Goals】
１. To understand the neural basis of cognitive functions, such as perception/movement and memory/learning.
２. To be able to plan and carry out neurophysiological experiments using humans and animals.
３. To be able to analyze data mathematically and explain it logically.
４. To be able to publish research results at conferences and as papers.

01

Research Field : Biomolecular Structural and Medical Sciences(Department : Medical Chemistry)

Professor

Takuya Kobayashi(Shimizu)【Research Fields】
The Medical Chemistry Department within the Faculty of Medicine aims to understand the chemical reactions of biomolecules that
control life phenomena, and to make use of them in medicine. With protein science (such as structural biology and biochemistry)and neuroscientific approaches, we examine the physiological and pathophysiological roles of protein molecules in livingorganisms by analyzing their functions from the atomic to individual levels. We explore and design chemical substances andmolecules that control protein molecules that could be potential drug targets. Our research methods include various approaches
from classical column chromatography protein purification to using columns to genome editing, structural analysis, molecularimaging, and behavioral analysis. While new discoveries are always needed in basic medical research, striving to be the first groupwith such breakthroughs is never easy. Grit, determination,, as well as colleagues who partner to overcome challenges together,are essential. Such experiments require flexible creativity, thinking power, innovative ideas, and abilities to take action and notmiss opportunities. Many colleagues in the Department of Medical Chemistry have research backgrounds in different fields. In thisdepartment, we aim for historic discoveries of novel drugs, thereby contributing to the next generation.
【Research Goals】
1. To be able to collect necessary information from reliable sources and derive unknown problems.
2. To be able to understand the principles of basic experimental techniques and use the techniques to solve the derived problem.
3. To be able to make an experimental plan for solving the problem, examine the results of the experiment that has been carriedout, and plan for the next experiment.
4. To be able to draw conclusions from a series of experimental results and publish them externally at conferences and as scientificpapers.

Research Field : Molecular Pharmacology, Matrix Biology and Medicine(Department : Pharmacology)

Professor

Tomoyuki Nakamura【Research Fields】
With the development of drug design and antibody drugs, there is an increasing number of means to inhibit or promote thefunction of target molecules in the living body. We believe that the most important task for the Department of Pharmacology of theFaculty of Medicine in such an era is to identify the target molecules that play an important role in the living body or in disease.
This requires a wide range of research techniques, such as biochemical/molecular biology methods, cell biology methods, andgeneration/analysis of genetically modified mice. We are conducting innovative research on novel target molecules by making
full use of these cutting-edge life science techniques. The main theme of our research is to study the mechanism of formation
and regeneration of elastic fibers, which are components of extracellular matrix. With this study, we aim to identify novel target
molecules for aging-related diseases, such as emphysema and arteriosclerosis. In addition, our lab members have developed theirown research themes suited to their interests, including the functions of sugar chains in the living body, the molecular mechanismof cardiac development, and circadian rhythm and cancers.
【Research Goals】
１．To learn molecular biology techniques using DNA, RNA, and proteins.
２．To learn cell biology techniques using cultured human and mouse cells.
３．To learn the methodology for generating, maintaining, and analyzing genetically modified mice.
４．To be able to find the literature that contains the experimental methods necessary to carry out his/her research project.
５．To be able to make an experimental plan that can produce meaningful results and analyze and interpret the data correctly.
６．To be able to present research content appropriately.
７．To be able to publish research content as papers in English.

02

Research Field : Pathology and Laboratory Medicine(Department : Pathology)

Professor

Koji Tsuta【Research Fields】
In our department, we aim to develop new diagnostics and treatments based on the histopathological findings obtained in actual
clinical practice. Using technologies such as tissue microarray and next-generation sequencing, we perform a wide range ofproteomic and genomic, searching for biomarkers related to prognosis and treatment selection. Furthermore, we test our hypotheses
based on molecular pathological analysis using engineering methods combined with biological models. We have revealed the
carcinogenic mechanisms, metastases, and cancer microenvironment of a wide variety of carcinomas, such as those affecting
respiratory organs, urinary renal organs, mammary glands, female reproductive organs, and the head and neck region, andreported findings that led to improved prognosis for patients. Recently, we have focused on precise tumor progression analysis byconstructing tissues three-dimensionally using a 3D printer, as well as the construction of a diagnosis and prognosis prediction
system using artificial intelligence technology in collaboration with the department of genome analysis. Therefore, we are focusing
on practical research that leads to the realization of better treatment and appropriate diagnosis, including morphological, protein,
and genetic abnormalities.
【Research Goals】
1. To understand adult tissue stem cells that support cellular metabolism to maintain normal structure and tissue homeostasis.
2. To be able to understand the pathological morphology of typical tumors and lesions.
3. To be able to use immunohistochemical and molecular biology methods properly and to troubleshoot.
4. To set a research topic and understand the necessary theory and matters that have been revealed previously.
5. To present research content appropriately.
6. To publish research content as peer-reviewed studies in English.

Research Field : Viral Oncology(Department : Microbiology)

Professor

Kazu Okuma【Research Fields】
It seemed that humanity was gradually freed from the threat of infectious diseases due to the rapid development of modern
microbiology, which began in the early 20th century. However, as we learned from the COVID-19 pandemic caused by the newcoronavirus (SARS-CoV-2), fighting new pathogenic microorganisms remains a major challenge for humanity, and even many
known infectious diseases, such as Ebola, cause a number of casualties in each epidemic. A weapon to combat these emerging andre-emerging infectious diseases is basic research in the field of microbiology. Microbiology has become not only the starting point
for the development of today's molecular genetics/biology and immunology but also the basis for discovering new phenomena andprinciples of life, which has also led to the development of current vaccines for COVID-19.
Why don't you learn the latest knowledge and technology in our laboratory and contribute to the world? We are currently studying
the pathogenic mechanism and treatment of adult T-cell leukemia (ATL) and neurological disease (HTLV-1-associated myelopathy,
HAM), which are the infectious diseases associated with human T-cell leukemia virus type 1 (HTLV-1), the first human pathogenic
retrovirus discovered, mainly using animal models. In addition to these, we hope to tackle emerging and re-emerging infectious
diseases, such as COVID-19, in the future.
【Goals】
１．To understand the changes in cellular functions due to viral infection and host immune response.
２．To understand the mechanisms of cellular tumorigenesis and antitumor immunity.
３．To learn technologies of gene and protein expression analysis using molecular biology techniques.
４．To learn technologies of blood cell and viral infection analysis using cell biology techniques.
５．To set a research topic and understand the necessary theory and previous findings.
６．To perform statistical analysis based on experimental data.
７．To present the research content appropriately.

03

Research Field : Regenerative Medicine（ Department : iPS Cell Regenerative Medicine ）【Research Fields】
The Department of iPS/Stem Cell Regenerative Medicine is a cross-disciplinary group that brings together specialists in regenerative
medicine research on the heart, liver, kidney, endocrine organs, blood, and skeletal muscle. Our three aims are as follows:
Professor

Hirofumi Hitomi

1. Developing differentiation induction methods using induced pluripotent stem (iPS) cells.
1. We are developing and improving the methods for differentiating human iPS cells into various cells. We have been studying themethods of inducing differentiation heart, liver, kidney, pancreas, blood vessels, endocrine organs, skeletal muscle, and blood
cells.
2. Generating disease models to elucidate mechanisms.
1. We generate disease models by inducing differentiation of human iPS cells. Although it is difficult to reproduce human diseases
in vitro, we examine the mechanisms of diseases using pathological models with newly generated human iPS cells. In addition,
we establish iPS cells from patients to determine pathophysiology and develop treatment methods.
3. Aiming for clinical application.
1. Cells induced from human iPS cells are used for the screening and efficacy evaluation of drugs. We aim not only for drug
evaluation but also for drug discovery.
【Research Goals】
1. Understand the latest research trends in regenerative medicine by carefully reading research papers and participating in seminars
and conferences
2. Learn and understand the use of laboratory notebooks, manage experimental data, plan experiments, research ethics, and similar
topics
3. Be able to identify issues from previously published regenerative medicine research and develop a research plan
4. Learn the basic techniques of regenerative medicine research to execute the research plan
5. Learn and understand how to apply for research grants and obtain external funding
6. Be able to present research in an appropriate manner
7. Publish research in the form of academic papers in international academic journals

Research Field : Innovative Regenerative Medicine（ Department : iPS Cell Regenerative Medicine ）Research Professor

Fumiyuki Hattori【Research Fields】
In the Innovative Regenerative Medicine Department of the Graduate School of Medicine, led by Dr. Fumiyuki Hattori, we are
actively working on the development of regenerative medicine of the heart, liver, pituitary gland, and salivary gland, as well asa wide range of research themes in the fields of COVID-19, skin, nail, skeletal muscle, cellular senescence, AI, and robotics, allthrough the lens of a new, creative perspective. The Innovative Regenerative Medicine Department has built collaborations withmultiple companies in a wide range of industries, and a total of 20 aspiring members with diverse backgrounds have gathered tocreate a free and open atmosphere.
【Research Goals】
1. To understand the current status and unsolved problems of regenerative medicine research.
2. To understand the embryological origin of organs, tissues, and cells to be treated.
3. To understand the causes and exacerbation mechanisms of diseases to be treated.
4. To be able to interpret experimental results independently and guide the research plan.
5. To be able to publish research results at conferences and as papers.

04

Research Field : Brain Development and Formation（ Department : iPS Cell Applied Medicine ）Professor

Keiko Muguruma【Research Fields】
One of the ultimate goals of neuroscience is the scientific understanding of the development, structure, and function of thehuman brain, the center of mind and intelligence, as well as the treatment of neurological and psychiatric disorders. However,approaches to human brain research are limited to non-invasive image analysis, such as MRI/PET, and the use of autopsied brains
and cell lines, thus empirical research on the human brain itself has been a challenge. Nevertheless, detailed measurement andanalysis at the genomic, molecular, cellular, and tissue levels using human samples are needed for understanding the humanbrain’s unique structure and function, as its complex structure and function are qualitatively different from those of other animals.
In light of these restrictions, we believe that advancements in human brain research would be made with the innovation of brainorganoids from pluripotent stem cells. In our department, we advance our research by utilizing pluripotent stem cells and organoid
technology to scientifically understand the human brain with the goal of contributing to conquering intractable diseases through theunderstanding of biological phenomena. We aim to understand neuropathological conditions, including intractable neurologicaldiseases, intractable ocular diseases, neuroendocrine disorders, and congenital brain disorders, by reproducing organ developmentwith ES/iPS cells and modeling disorders. Through collaborative research with various clinical and basic researchers inside andoutside the university, promotion of cross-disciplinary collaboration, such as the development of image analysis techniques andculture materials, and cooperation of patients, we aim to understand the human brain and develop drugs and treatments to conquer
intractable diseases and rare disorders.
【Research Goals】
1. To learn basic and latest knowledge of embryology and neuroscience.
2. To be able to acquire and make full use of differentiation induction technology of pluripotent stem cells, imaging technology, andquantitative analysis technology.
3. To be able to plan and carry out experiments related to the research on the structure, function, development of the brain anddisease research.
4. To be able to analyze and interpret experimental results correctly.
5. To be able to present research results appropriately.

Research Field : Public Health and International Health(Department : Hygiene and Public Health)Professor

Toshimasa Nishiyama【Research Fields】
In our department, the Department of Hygiene and Public Health, we aim to educate researchers who can understand preventive
medicine and human health management and/or health hazards from the global fields, including infectious prevention, tropical
medicine, international health, and elderly care. We expect the student can understand the current issues through field surveys andexperiments, collect and analyze data necessary for research, and independently design experimental plans.
One of our current research topics is human health management and health hazards for international health, especially indeveloping countries. To prevent infectious diseases, we focus on epidemics surveys of dengue fever in the Lao PDR. We also
conduct the research for developing a dengue fever control program by using mosquito larval insecticide and genetically analyzing
the genealogical tree of dengue virus, which is the pathogen of dengue fever. We keep challenging to resolve the world wide
problems in international health and serious infections diseases.
Additionally, we also address the issue on the ageing society and aged care. It is important for ageing people to keep the quality oflife (QOL) and avoid long-term care. Therefore, we investigate to improve the frailty for aged people.
【Goals】
1. To be able to understand the structure and function of human health.
2. To understand the legal system in public health.
3. To learn basic techniques for identifying pathogens, as well as diagnosing tropical diseases.
4. To learn basic techniques related to the health management of overseas travelers, such as vaccinations.
5. To conduct and evaluate/analyze the health surveys of caregivers and those in need of nursing care in aged care.
6. To set a research task, and to understand logically for the theory and previous papers.
7. To be able to perform statistical analysis based on experimental data.
8. To be able to present research results appropriately.

05

Research Field : Molecular and Cell Biology(Department : Hygiene and Public Health)Professor

Toshimasa Nishiyama【Research Fields】
The field of Molecular and Cell Biology aims to develop researchers who can understand the basic principles of cell biology
and genetic engineering by conducting basic and clinically relevant medical research, using knowledge and techniques inbiotechnology, as well as independently formulating experimental plans by collecting and analyzing the data necessary for
research.
Our current research themes include the practical application of diagnostic kits using novel biomarkers for tuberculosis infections.
Tuberculosis, which causes droplet nuclei infection, is a serious infectious disease that spreads if the diagnosis of active tuberculosis
is delayed, requiring global public health measures. Thus, using samples that can be easily obtained without collecting blood, we
began our research on a new rapid diagnostic method for active tuberculosis that can be easily and quickly performed even indeveloping countries. In collaboration with researchers in the Lao People’s Democratic Republic, we have successfully detected an
index that could be a diagnostic biomarker of active tuberculosis. We aim to further examine the results of this preliminary researchand to develop a new tuberculosis diagnostic kit that can quickly and reliably identify a tuberculosis infection using a novel
biomarker.
Furthermore, we try to clarify the mechanisms of traditional Chinese herbal (Kampo) medicine at the molecular level against
menopausal diseases and osteoporosis. Kampo is a natural product of herb and some of them has estrogenic activity. In order toevaluate the effects of Kampo medicine especially against osteoporosis, we conduct the research in vitro and in vivo.
【Research Goals】
1. To understand the concept of molecular and cell biology.
2. To understand the characteristics of bacterial and viral infections.
3. To learn basic molecular and genetic laboratory techniques.
4. To set a research topic and understand the necessary theory and matters that have been revealed previously.
5. To be able to read the information in the experimental data and explain the phenomenon.
6. To be able to summarize research content and present it appropriately.

Research Field : Epidemiology and Preventive Medicine(Department : Hygiene and Public Health)Research Professor

Katsuyasu Kouda【Research Fields】
As its main research theme, Epidemiology and Preventive Medicine is currently working on the research on the prevention oflifestyle-related diseases for local residents, which include cardiovascular diseases, glycolipid metabolic diseases, and osteoporosis.
We are also conducting epidemiological studies on the prevention of infectious diseases, such as tuberculosis.
Epidemiological studies aim to analyze various factors affecting health and illness through data from large-scale surveys of local
residents. Of those factors, beneficial and harmful ones are quantified to derive measures aiming to enhance the former andattenuate the latter, which are then evaluated. The results of the studies can be directly returned to the real world, in addition tosatisfying our academic interests.
Furthermore, epidemiological studies also aim to clarify the overall picture of diseases and the factors that determine their onset,
course, and outcome using clinical data from medical institutions and to show the intensity and magnitude of the effects of eachfactor quantitatively. Therefore, epidemiology provides physicians with the scientific basis necessary for considering the medical
treatment policy of their patients in the medical field in the real world.
【Goals】
1. To learn the methods to conduct large-scale surveys of people.
2. To learn the methods to control bias in relatively small data, such as clinical data.
3. To learn techniques from the handling of raw data to aggregation, statistical analysis, interpretation of results, and writing of
papers.
4. To learn the theories and methods in statistics necessary for evaluating medical data.
5. To learn the methods to implement health care based on scientific evidence.

06

Research Field : Forensic Science(Department : Legal Medicine)

Professor

Atsushi Akane【Research Fields】
In our department, judicial autopsies are commissioned from the Osaka Prefectural Police Headquarters and the Osaka District
Public Prosecutors Office to investigate the causes of death of criminal cadavers. DNA variants, drugs and poisons in the bodies arealso analyzed. Personal identification is performed by DNA profiling. For the forensic purposes, we are developing three researches
as follows:
1. Forensic application of the next-generation sequencing: We study applicability of the technology analyzing hundreds tothousands gene variants simultaneously to personal identification and detection of genetic predispositions of fatal diseases.
2. Development of a probabilistic genotyping method to interpret DNA profiles derived from DNA mixtures: We are developing
a probabilistic genotyping software to detect DNA profiles of suspects and victims in the STR (short tandem repeats)
electropherograms, and verifying its usefulness in actual cases of DNA profiling.
3. Study on the effects of synthetic cannabinoids: We are studying pharmacokinetics of synthetic cannabinoids, known as
dangerous synthetic drugs in Japan, in blood and brain of laboratory animals and researching the inducing effect of catalepsy.
【Research Goals】
1. To be able to understand the phenomenon of human death and the pathophysiology of fatal injuries, asphyxiation, poisoning,and diseases.
2. To be able to understand the principles and methods of personal identification.
3. To be able to retrieve and read research papers to design the research theme and the experimental methods.
4. To be able to analyze experimental results statistically.
5. To be able to present research findings appropriately.

Research Field : Cell Signaling（ Department : Bioinformatics ）Associate Professor

Satoshi Matsuda【Research Fields】
Immunity is an important mechanism that protects from the threat of infection. However, excessive immune response sometimes
causes suffering in the form of seasonal allergies. Many of the seasonal allergy medicines in use today are for controlling symptoms.
However, if we could understand why some people have seasonal allergies while others do not, we may be able to find a newtreatment for seasonal allergies that intervenes at the mechanistic level. Focusing on the MAPK and mTORC1 pathways, which are
typical signal transduction pathways for cells to receive extracellular information, our laboratory aims to deepen our understandingof the mechanism by which the immune system works normally, and to develop artificial immune control methods using thismechanism. In addition, substances are constantly exchanged within the cell via vesicles, and abnormal vesicle transport hasvarious effects on the cell response. We have very recently discovered that the Arf pathway, which controls vesicle transport, plays
an important role in the immune system, thus we are also working on the development of new treatment methods for autoimmune
diseases that target the Arf pathway.
【Research Goals】
1. To understand the signal transduction pathway involved in the activation of immune cells.
2. To understand the molecular mechanism of immune tolerance induction and its impairment.
3. To understand immunodeficiency and autoimmune pathology at the molecular level.
4. To publish research content at international conferences.

07

Research Field : Laboratory Animal Medicine(Department : Animal Models for Human Diseases)

Associate Professor

Sung-Il Lee【Research Fields】
Experimental animals have made significant contributions to medical research. The use of experimental animals will continue tobe essential, and is expected to develop even further. However, it is necessary to make efforts to reduce the number of animals
used in experiments, to find alternatives, and to minimize the pain experienced by animals when use is unavoidable; essentially,
to follow the “three Rs” of animal research: reduction, refinement, and replacement. From the standpoint of animal protection,
we are making efforts to improve the health, medicine, and welfare of the animals used in experiments. We conduct researchusing experimental animals, such as generating genetically modified animals or infected animals, as well as performing surgicaltreatment, to create disease model animals. In addition to such in vivo research, we actively conduct in vitro research using celllines as an alternative to animal models. Through these, we are promoting research on the elucidation of life phenomena, thedevelopment and evaluation of antiviral drugs, treatment methods and drugs for immune and metabolic bone diseases, as well as
the determination of the mechanisms of various diseases.
【Research Goals】
1. To gain knowledge of, and skills for, ethical scientific animal experiments.
2. To be able to understand and apply/implement welfare and disease management related to experimental animals.
3. To be able to set a research topic and generate genetically modified animals and disease model animals using developmental
engineering technology.
4. To be able to analyze data by establishing a useful experimental system that makes use of the characteristics of model animals.
5. To be able to summarize research content as papers and appropriately disseminate it to society.

Research Field : Functional Neuroscience（ Department : Functional Neuroscience Genetics ）Research Institute Professor

Reiko Kobayakawa【Research Fields】
Humans and animals have evolved latent life-protective abilities to survive in crises. However, it remains unclear what types ofprotective abilities exist, whether sensory stimuli can artificially induce them, and whether such induction methods can be used
as medical technology. We found that activation of TRPA1 in the vagus and trigeminal nerves, and the olfactory receptors in theolfactory sensory neurons by thiazoline-related fear odors (tFOs) that satisfy specific chemical structural rules orchestrate various
physiological responses. These physiological responses include hypometabolism, hypoxia resistance, and anti-inflammatory
immunoenhancement, which increased survival in crises and lethal pathological models. We advocate the application of thisphenomenon as “sensory medicine,” a technology that uses sensory stimuli to induce latent life-protective effects via the brain.
TFOs directly bind to TRPA1 in the vagus and trigeminal nerves; their sensory information activates the central crisis pathway from
Sp5/NTS in the brain stem to PBN in the midbrain, which orchestrates various physiological responses. In our research department,
we are studying the mechanisms of how sensory receptors recognize odor information and transmit crisis information to the brain
and how the brain evaluates crisis information and induces a systemic physiological response. Sensory medicine technology has
been found to be able to treat pathological models of sepsis, ischemic heart disease, and cerebral infarction, which continue
to cause the largest number of deaths in the world, and we are aiming for early commercialization of the technology as humantherapeutic drugs.
【Research Goals】
1. To learn skills to formulate a research plan, carry out research independently, and publish the results as papers.
2. To understand molecular biology techniques and learn the skills to generate genetically modified model mice.
3. To learn the skills to examine genetically modified model mice using molecular biology, biochemistry, and physiology methods.

08

Research Field : Genomic Medicine(Department : Genome Analysis)

Research Institute Professor

Koichiro Higasa【Research Fields】
Our department promotes exploratory research on genetic factors related to the onset and prognosis of various diseases for thedevelopment of Precision Medicine, which is personalized medicine based on genome information. Our research targets the entire
human genome, which contains a huge amount of information, to elucidate the causes of diseases using statistical genetics andcomprehensive advanced bioinformatics approaches, such as cutting-edge machine learning and parallel computing techniques.
In 2013, we launched the first database of genetic variation in the Japanese population, the Human Genetic Variation Database(HGVD), which has facilitated refined genetic analyses such as the efficient survey of causative mutations associated withintractable diseases or cancer, precise genotype imputation in genome-wide association studies, and prediction of side effects ofdrugs. Dissemination of genomic information by means of HGVD is expected to have applications in the future development of
personalized medicine.
【Research Goals】
1. To develop theories and analytical technologies related to statistical genetics and bioinformatics.
2. To construct algorithms and techniques for performing genome analysis to explore disease-related genetic factors.
3. To acquire knowledge related to promoting personalized medicine and genetic diagnosis based on genomic information.
4. To develop skills for making research plans, conducting research, and publishing papers.

Research Field : Genome Engineering（ Department : Genome Editing ）Distinguished Associate Professor
appointed by the University President

Keizo Tokuhiro【Research Fields】
We research the molecular mechanisms of the early developmental process in fertilization in vivo. Studies on fertilization
require the collection of eggs and sperms from living organisms, which is expensive and time-consuming, and many fertilization
mechanisms remain unknown. In addition, although the methods for producing fertilizable ova from iPS cells in in vitro culture
have been developed, the formation of motile sperm in in vitro culture has not succeeded, and these methods still pose highhurdles for the use in general research. In recent years, genome editing using the CRISPR/Cas9 system has allowed the generationof gene-deficient mice and in vivo functional analysis with ease, leading to rapid progress in the elucidation of molecularmechanisms. Our laboratory also aims to develop new genome editing technology, while utilizing existing technology tounderstand the details of the molecular mechanisms of fertilization in vivo. Furthermore, we will examine various biologicalphenomena and elucidate molecular mechanisms by inserting loss of function mutations and genes encoding fluorescent proteins
into cultured cell lines with genome editing technology.
【Research Goals】
1. To understand research methods using genome editing technology and learn genomic editing skills in cultured cells or fertilizedeggs.
2. To learn the techniques to analyze the molecular mechanisms of biological phenomena and diseases using genetically modifiedmice.
3. To learn the skills to formulate a research plan, carry out research independently, and publish the results as papers and atconferences.

09Research Field : Cancer Biology（ Department : Cancer Biology ）Distinguished Professor appointed
by the University President

Takeharu Sakamoto【Research Fields】
Cancers in human bodies are promoted by various factors (e.g. gene mutations, an accumulation of DNA damages etc.) andoften gain malignancy by interacting with their surrounding factors generally called tumor microenvironments. The main focusof researches in our department is to elucidate the mechanisms of cancers gaining malignancy through interactions with tumor
microenvironments and further identify the novel therapeutic targets/drugs. Based on our aims of research, we are currently working
on the following projects related to following contents:
1.
2.
3.
4.

Elucidation of molecular mechanisms involved in cancer microenvironment and inflammation regulation.
Elucidation of drug resistance mechanisms in cancer.
Elucidation of mechanisms underlying cancer progression and metastasis through cancer-stroma interaction.
Drug discovery research targeting novel cancer microenvironment-regulating molecules.

【Research Goals】
1. To attain proficiency in molecular biological techniques involving DNA, RNA, and proteins.
2. To be trained in cell biological techniques such as culture of human and mouse cells.
3. To develop the skills required to analyze carcinogenesis, tumor growth, and metastasis using genetically modified mice.
4. To be knowledgeable in techniques for analyzing information in public databases such as expression and mutation of cancer
genes.
5. To acquire the skills to plan and conduct research independently, logically explain the validity of the results, and present theresults in papers and academic conferences.

Research Field : Photoimmunotherapy(Department : Fundamental Technology Development )Research Institute Professor

Hirofumi Hanaoka【Research Fields】
Photoimmunotherapy is a treatment that selectively kills the cancer cells to which the drug is bound. An antibody-IR700, a
photoactivating chemical, conjugate is used as a drug for photoimmunotherapy. After the drug has accumulated in the cancer,
near-infrared light is exposed to the entire cancer tissue. The therapeutic mechanism of photoimmunotherapy is that thephotoinduced chemical change of IR700 causes the cell membrane damage, and water flows into the cell, which eventually leads
to rupture of the cell. Thus, normal cells are not injured even if the drug is present nearby, which is the reason for its selectivity
for cancers. Currently, only photoimmunotherapy targeting EGFR is in clinical use, but with the development of drugs for new
target molecules, photoimmunotherapy can be applied to wide variety of cancers. So, our research aim is to develop a novel
photoimmunotherapy drug and we promote the following research.
1.

Exploring a novel target for photoimmunotherapy.

2.

Design and production of novel photoimmunotherapy drugs.

3.

Basic evaluation of photoimmunotherapy drugs in vitro and in vivo.

【Research Goals】
To learn basic techniques rerated to photoimmunotherapy research.
To learn how to plan and conduct research.
To be able to present research results appropriately.

10Research Field : Vaccine Immunology(Department : Immunology )Research Institute Professor

Hidehiro Fukuyama【Research Fields】
The antibodies play a crucial role in recognizing and eliminating pathogens from the body. With around one trillion repertoiresof antibodies, considering that the human genome has around 20,000 genes, the diversity of antibodies is a remarkable number.
In recent years, leveraging this diversity, antibody therapeutic drugs and diagnostic medications for diseases such as cancer andAlzheimer's have been developed.
The discovery of "human" antibodies is a novel area of research. Isolating antibodies directly from humans offers two advantages: (1)immediate application to humans and (2) enhanced safety. For instance, human antibodies isolated from convalescent COVID-19
patients were rapidly applied for treatment in humans. The process of isolating effective antibodies from human samples, however,presents experimental design challenges. We are committed to developing a high-throughput screening method to obtain humanantibodies against various types of tumors, which will be applied to antibody-drug conjugate-based cancer therapies, including
photoimmunotherapy.
In addition, we are actively engaged in developing a new-generation vaccine system by identifying novel adjuvants and introducing
a needleless vaccine system. This approach aims to provide easy and safe access to medical welfare, especially in situations where
there is a shortage of human resources. The following link provides examples of the outcomes and directions of our research:https://www.youtube.com/watch?v=iYk6nZoKau8
https://www.youtube.com/watch?v=K68azXjhgp8【Research projects】● Human antibody discovery for cancers● Revealing mechanism of Immune memory reaction● Designing synthetic vaccine antigen inducing highly specific and effective conformation-specific antibody● Finding novel adjuvants● Developing needless vaccine system● Elucidating mechanism of immune tolerance for vaccine design● Unveiling the immune regulatory mechanisms via peripheral nervous system

Research Field : Molecular tumor pathology and medicine(Department : Tumor Pathology )【Research Fields】
Our department specializes in tumor pathology, and the basic pathology promotes research to elucidate the key molecularmechanisms of growth, invasion and metastasis of malignant tumors, especially focusing on intractable cancers, for clinicaldiagnosis and application. Elucidating the mechanisms of tumor resistance against advanced drugs is also an important issue, wehave created a practical pathological research system that integrates molecular and histopathological analyses. Our goal is to findDistinguished Professor appointed by
the University President
important clues for overcoming cancer that can be applied to clinical practice. With the aim of applying the research to cancer
Eisaku Kondo
therapeutics, we are also paying an effort to develop an innovative medical technology such as novel peptides and antibodies
to target cancer for next generation tumor medicine. We believe this research is quite unique in pathological department. Our
department aims advanced and comprehensive molecular tumor pathology through crosstalk with the forefront of cancer medicine
in the 21st century.
Followings are the subject in our research;
1. Exploring the novel tumor markers and key regulators to elucidate molecular mechanism of growth and invasion/metastasis forcancer diagnostics and therapy.
2. Developing the cancer-targeting agents of novel modality, especially focusing to the novel DDS-based anti-tumor drug targeting
intractable/advanced stage cancer.
【Research Goals】
1. To learn basic skills including histopathological and molecular analyses of tumor cells and tissues.
2. To learn in vitro cell culturing and prepare in vivo tumor models using mice for experiments.
3. To know how to interpret the experimental result and work out the strategy by themselves for next step in their own research.

11

Research Field:Hematology, Respiratory Medicine, Rheumatology and Infectious Disease Medicine(Department : Internal MedicineⅠ)

Professor

Tomoki Ito【Research Fields】
The Department of Internal MedicineⅠmanages tumors, infectious diseases, and immune diseases, all of which involve biologicaldefense/immunity pathology. Thus, a research theme essential for understanding and treating these diseases is “immunology.”
Currently, it seems that treatment strategies using external factors, such as anticancer drugs and antibiotics, are reaching their limits.
Therefore, we believe that it is important not only to view immunology as a basic discipline but also to link it to clinical diseases in
the future, leading to the establishment of new treatment strategies. The research theme of our department is to conduct clinical andbasic research using human dendritic cells that control the immune system. As a specific goal in the near future, we plan to develop
new drugs discovery and diagnostic methods targeting dendritic cells.
【Research Goals】
1. To understand the functions of major immune cells, such as dendritic cells, T cells, and B cells, in the immune system forbiological defense.
2. To understand the concepts of innate immunity and acquired immunity, as well as their differences.
3. To understand transplant-related immunity (such as GVHD).
4. To learn the basic techniques of in vitro experiments using human cells and in vivo experiments using mouse models.
5. To perform statistical analysis based on experimental data.
6. To present research content.

Research Field : Cardiology, Nephrology, and Endocrinology and Metabolism(Department : Internal Medicine Ⅱ)

Professor

Ichiro Shiojima【Research Fields】
・Myocardial regeneration using human heart-derived tissue stem cells: We have found human circulating blood contains progenitor
cells that can differentiate into cardiomyocytes, smooth muscle cells, and endothelial cells. These cells, expressing mesenchymal
stem cell markers and vascular endothelial cell markers, are called circulating mesangioblasts (cMAB). We work to apply cMAB to
myocardial regeneration, in addition to clarifying their origin.
・Search for the causative gene of hereditary kidney disease: We are searching for the causative gene of hereditary kidney disease
that develops due to a single gene mutation. Chronic kidney disease (CKD) is a multifactorial disease, and we aim to establish
new treatment methods for CKD through elucidation of the pathophysiology of hereditary kidney disease.
・Effects of postprandial hyperglycemia on the functions of bone marrow: Postprandial hyperglycemia has been shown to play
an important role in the development of macrovascular diseases associated with diabetes. We are working to understand thepathogenic mechanism of macrovascular diseases derived from diabetes by investigating the effects of postprandial hyperglycemia
on vascular endothelial progenitor cells in the bone marrow.
【Research Goals】
1. To set a research theme and make a research plan.
2. To learn the methodology required for research planning.
3. To interpret the obtained data and plan necessary experiments and data collection.
4. To present research content appropriately.
5. To publish research results as scientific papers.

12

Research Field : Endocrinology and Metabolism(Department : Internal Medicine Ⅱ)

Clinical Professor

Nagaoki Toyoda【Research Fields】
Thyroxine (T4), which is secreted mainly from the thyroid gland, is considered a precursor hormone and is converted to theactive hormone 3,5,3’-triiodothyronine (T3) by the 5’-deiodination reaction. On the other hand, T4 is also converted to theinactive hormone 3,3’,5’-triiodothyronine (reverse T3) by the 5-deiodination reaction. The 5’-deiodination reaction is catalyzed
by type 1 and type 2 iodothyronine deiodinases (D1 and D2, respectively), while the 5-deiodination reaction is catalyzed bytype 3 iodothyronine deiodinase (D3). Thus, intracellular T3 concentration is increased by D2 while decreased by D3. In fact,
D3 gene-deficient mice (D3KO) have impaired glucose tolerance, and secretion of glucose-responsive insulin is reduced in islets
isolated from D3KO mice. Our research aims to elucidate the physiological significance of D3 in the process of differentiation andmaturation of human iPS cells into pancreatic β cells.
【Research Goals】
1. To understand the mechanisms of carbohydrate metabolism and the expression of thyroid hormone actions.
2. To learn cell culture methods and molecular biology methods.
3. To set a research topic and understand the necessary theory and matters that have been revealed previously.
4. To perform statistical analysis based on experimental data.
5. To present research content appropriately.

Research Field : Clinical Arrhythmia(Department : Internal Medicine Ⅱ)

Clinical Professor

Masahiko Takagi【Research Fields】
We research the latest non-invasive methods, such as a site-specific Holter signal-averaged electrocardiography, for detecting
electro-cardiac abnormalities like J wave and Brugada syndromes, which are causative diseases of sudden death in young people.
We also study the therapeutic effects of non-drug treatments (catheter ablation and implantable cardioverter-defibrillator) on
refractory ventricular arrhythmia. Our clinical research on catheter ablation focuses on the identification of substrates of arrhythmia
using a high-resolution three-dimensional mapping system (Rhythmia System ™ [Boston Scientific, Massachusetts, USA], Ensite
System ™ [Abbott Medical Japan, Tokyo, Japan]) and prevention of recurrence by the substrate ablation, while our clinical researchon implantable cardioverter-defibrillator focuses on methods to reduce inappropriate therapy and avoiding shock treatment. Thesestudies aim to develop treatment methods that improve the prognosis of patients. Furthermore, we are also actively introducing
a remote monitoring system for patients with cardiac implantable devices, which receives remote transmission data regularly todetect and intervene in arrhythmic events and device malfunctions at an early stage, and we study the effects of early intervention
on the improvement of life prognosis.
【Research Goals】
1. To understand treatment methods for arrhythmia and learn basic techniques.
2. To set a research topic and understand the necessary theory and matters that have been revealed previously.
3. To collect and analyze data accurately.
4. To present research content appropriately.
5. To publish research results at domestic and overseas conferences.
6. To summarize research results and publish them as scientific papers.

13

Research Field : Gastroenterology and Hepatology（ Department : Internal Medicine Ⅲ)

Professor

Makoto Naganuma【Research Fields】
Research on the gastrointestinal tract
Using clinical specimens after endoscopic resection for esophageal cancer, gastric cancer, and colorectal cancer, we aim
to elucidate the etiologic role of transforming growth factor (TGF) β signal transduction mechanisms, as well as research themechanisms of carcinogenesis, progression, and metastasis. In addition, our study on the involvement of regulatory T cells
in colorectal cancer metastasis using extracellular vesicles was selected as the Best Abstract Award of the United European
Gastroenterology in 2021. Furthermore, , nationwide clinical research with multicenter study was conducted as a principal
investigator to create clinical evidence directly linked to medical care at the Japan Agency for Medical Research and Development.
Research on the liver
We perform basic research on the mechanisms of hepatic fibrosis and hepatocarcinogenesis, focusing on TGF-β signal transduction,
aiming for clinical application. In addition, with the current need for digitization in medical care, we are also conducting researchon application development based on AI technology for alcoholic liver disease and non-alcoholic steatohepatitis.
Research on the pancreas and bile duct
In addition to contributing to the revision of diagnostic criteria and clinical practice guidelines for acute pancreatitis, chronicpancreatitis, and autoimmune pancreatitis, we research the involvement of intestinal flora in pathophysiology. In addition, as
clinical research unique to our department, we have reported a surveillance method aimed at early detection of pancreatic cancer
and a photodynamic pancreatic cancer screening method using 5-aminolevulinic acid.
【Research Goals】
1. To make an experimental plan based on a research theme.
2. To learn the experimental methodology necessary for the experimental plan.
3. To analyze and interpret obtained data by presenting it.
4. To summarize and submit data as papers and present it at major domestic and overseas conferences, disseminating results andreceiving evaluations.
5. To experience and understand medical research through a series of studies.

Research Field : Thoracic Oncology(Department : Thoracic Onoclogy )Professor

Takayasu Kurata【Research Fields】
The Department of Thoracic Oncology provides medical care, focusing on chemotherapy and palliative care for patients withmalignant tumors of the chest (mainly lung cancer). Chemotherapy for lung cancer has made significant progress in recent years
due to the development of molecular-targeted drugs based on actionable genetic abnormalities in tumor tissues and immune
checkpoint inhibitors. However, studies on resistance mechanisms in molecular-targeted drug therapy, as well as studies on
effect prediction factors and resistance biomarkers for immune checkpoint inhibitors, are considered to be unmet needs, and ourdepartment aims to promote the research on these topics. In addition, while advancing the use of these drugs in precision medicalcare, we aim to actively promote pharmacokinetic research to examine the characteristics of each drug.
【Research Goals】
1. To understand the characteristics, treatment concepts, and prognosis of malignant tumors.
2. To understand the concept of clinical trials.
3. To learn basic knowledge and techniques necessary for basic cancer research.
4. To set a research topic and understand the necessary theory and previous data.
5. To perform statistical analysis based on experimental and clinical trial data.
6. To present research content appropriately.

14

Research Field : Psychosomatic Medicine(Department : Psychosomatic Medicine)

Professor

Hideaki Hasuo【Research Fields】
With current changes in social and medical paradigms, disease structures have begun to change in recent years. In a growing
number of diseases, general medical examinations of persistent physical symptoms reveal no corresponding abnormalities, forwhich medical approaches tend to be less effective, and we have also begun to find psychosocial factors involved in an increasing
number of cases. Among those, functional somatic syndrome, a collective term for functional diseases including irritable bowel
syndrome, functional dyspepsia, and fibromyalgia, has been reported to have common pathological conditions, and the elucidationof their pathophysiology, as well as the examination of countermeasures, is needed due to their clinical significance. In our
department, we mainly examine psychosomatic and functional pathological conditions of functional somatic syndromes andchronic pain syndromes, as well as their countermeasures, from various angles. Recently, we also examine the psychosomaticconditions of physical symptoms in patients with cancer and their family caregivers, and the interaction between them.
Focusing on “psychosomatic correlation,” which is the main theme of psychosomatic medicine, we aim to examine complex anddiverse pathological conditions by understanding how factors at various levels, from basic physiology to interpersonal systems, areinvolved in pathological conditions. Although measurements of physiological functions are often used in such studies, they require
dynamic measurements, such as fluctuation due to stress load and 24-hour continuous measurements in normal daily life, rather
than conventional static measurements. In addition, we use multivariate statistical analyses, such as path analysis, to examine therelationships between multiple factors. Furthermore, qualitative research methods, including conversation analysis, are used toanalyze the relationship between physicians and patients. We conduct clinical research in psychosomatic medicine by making fulluse of a variety of these methods.
【Research Goals】
1. To understand the effects of psychological aspects on physical conditions, and conversely, the effects of physical aspects on
psychological conditions.
2. To understand the formation of pathological conditions through interaction and circulation.
3. To learn measurement methods of psychological aspects and measurement techniques of physical functions.
4. To set a research topic regarding the pathophysiology of psychosomatic correlation and understand the necessary theory andprevious research results.
5. To perform statistical analysis of psychological and physical multivariate data by selecting appropriate methods.
6. To present research content appropriately.

Research Field : Neurology(Department : Neurology)【Research Fields】
a. Cerebral small vessel disease: Cerebrovascular disorders that cannot be detected on image analyses are involved in stroke, dementia, and aging.
Methods for evaluating cerebral small blood vessels from various aspects using lesions on brain MRI, as shown in Figure 1, have been recently
proposed. We aim to clarify the clinical significance of cerebral small vessel disease by constructing a scoring model using these images:
Professor

Yusuke Yakushiji

Figure 1. Representative images of neuroimaging markers
for cerebral small vessel diseaseb. Basal ganglia: Drug efficacy is known to diminish with the progression of Parkinson’s disease, and we aim to elucidate thepathophysiology of the underlying mechanism using Parkinson’s disease model animals. We evaluate the effects of various drugs by using
unilateral Parkinson’s disease model rats, which are generated by injecting 6-OHDA into one side of the medial forebrain bundle (MFB).

Figure 2: Experiments of Parkinson’s disease model animals
c. Neuropathology: Through immunohistological examinations of human brain specimens and gene expression/protein analyses of frozen autopsy
materials, we aim to elucidate the pathogenic mechanism of various neurodegenerative diseases and develop treatment methods rooted in thepathophysiology. Our research mainly targets amyotrophic lateral sclerosis, progressive supranuclear palsy, and frontotemporal dementia.
【Research Goals】
1. To be able to understand the molecular pathology of neuromuscular diseases and cerebrovascular diseases.
2. To learn basic research techniques and methods necessary for elucidating the above pathological conditions.
3. To choose a research issue in the research topics below and understand the necessary theory and published data.
4. To make a research plan to solve the research issue, carry out the research under the guidance, and report the results regularly.
5. To publish the results of the above goals as peer-reviewed papers.

15

Research Field : Neuropsychiatry(Department : Neuropsychiatry)

Professor

Toshihiko Kinoshita【Research Fields】
The Department of Neuropsychiatry conducts research with an emphasis on answering clinical questions and needs, focusing on
neurophysiology, clinical psychopharmacology, pharmacogenomics, and neuroimaging, aiming to optimize “precision medicine”
for each patient. The therapeutic effects of antidepressants and antipsychotics vary depending on the patient, which has been aheavy burden on patients. In the search for predictors of treatment response, we have found genes predictive of clinical response
through meta-analysis and analysis of monoamine-related genes and neuroplasticity-related genes. These results have been
published in a number of psychiatric journals. By combining those genes with various biomarkers(miRNA, methylation, proteins,qEEG; quantitative electroencephalogram) and neurocognitive tests, we are aiming to build and clinically utilize technology to
predict in advance the best treatment, like drugs, neuromodulation, or psychotherapy, for each patient. Based on our continuous
research and sampling, our department has a lot of valuable data, which is one of the best in Japan. Our main overseas joint
research facilities include the University of Bern (Switzerland), the University of Bologna (Italy), Karolinska Institute (Sweden),Harvard University, Stanford University (USA), and the University of Munich (Germany), allowing students to study abroad at highly
specialized universities.
【Research Goals】
1. To clarify clinical questions and appropriately extract the elements necessary for their resolution while examining previous
studies.
2. To learn the techniques to formulate, execute, and present a research plan to resolve clinical questions.

Research Field : Pediatrics(Department : Pediatrics)

Professor

Kazunari Kaneko【Research Fields】
With the advancements in gene analysis technology using next generation sequencing, knowledge on the human intestinal flora
has accumulated, and its association with overall health is garnering attention. The intestinal flora plays an important role in thebody, including nutrient metabolism and synthesis, infection protection against pathogens, and immune regulation. Therefore,
it has become clear that various diseases are triggered by the disorder of the constituent bacterial species of the intestinal flora(dysbiosis). In young children, dysbiosis of the intestinal flora has been suggested to be associated with inflammatory bowel disease,
irritable bowel syndrome, neonatal necrotizing enterocolitis, allergies, autism, obesity, diabetes, autoimmune diseases, and sudden
infant death syndrome. Thus, our laboratory in the Department of Pediatrics of Kansai Medical University is studying dysbiosis of
the intestinal flora in various diseases of young children using next generation sequencing. Our results suggest that dysbiosis due
to cesarean delivery may be corrected with a small amount of breast milk feeding. Furthermore, we have demonstrated that the
proportion of butyric acid-producing bacteria is reduced in patients with idiopathic nephrotic syndrome and that the number ofrecurrences can be reduced by the administration of butyric acid-producing bacteria.
【Goals】
1. To understand the physical and psychological characteristics of healthy children.
2. To understand the characteristics of diseases of young children.
3. To understand the basic techniques of gene analysis.
4. To perform basic handling of experimental animals.
5. To learn the basic techniques of cell culture.
6. To set a research topic and to study and understand the necessary theory and previous research.
7. To be able to perform correct statistical analysis based on experimental data.
8. To be able to present research content appropriately.

16

Research Field : Surgery(Department : Surgery)

Professor

Mitsugu Sekimoto【Research Fields】①We investigate the effects of virus therapy with third-generation proliferative recombinant
HSV-1 (T-01) as a novel treatment for advanced liver cancer, treatment-resistant sarcoma,
and neuroendocrine cancer. T-01 is an oncolytic virus that elevates the efficacy andsafety of G207, which has been shown to be effective against various human tumors in
nonclinical studies, and enhances antitumor immunity.
②Sepsis is a highly lethal pathological condition accompanied by inflammation, andeffective therapeutic agents and methods for sepsis have not been established. We aim
to develop drugs with an anti-inflammatory action that are highly effective against sepsis
by using an evaluation system that combines ex vivo (primary cultured hepatocytes) andin vivo (endotoxin sepsis model) data with the use of a rat animal model.
③The indocyanine green (ICG) liposome, developed as a drug delivery system (DDS)
preparation, has a hyperthermic effect, a photodynamic effect, and an antitumor effectdue to local release of an anti-cancer drug, all of which are triggered by near-infraredirradiation. ICG is expected to induce cancer immunity by releasing cancer antigens.
We are investigating its effects as a next-generation photoimmunotherapy.
④In anti-cancer drug treatment, it is important for the drug delivery system (DDS) toallow a higher dose of drugs or drugs at effective concentrations to maintain theirantitumor effects for a long period of time. We are developing a novel DDS using apolycaprolactone (PCL) sheet that encapsulates anti-cancer drugs, aiming to exert anantitumor effect effectively and continuously with a smaller amount of anti-cancer drugs
compared to their systemic administration.
【Research Goals】
1. To understand the pathophysiology of diseases in gastrointestinal surgery, breast surgery, and pediatric surgery.
2. To understand the latest advances and new research prospects in surgery.
3. To set a research topic and understand the necessary theory and previously discovered evidence.
4. To perform statistical analysis based on experimental data.
5. To present research content appropriately.

Research Field : Liver Surgery(Department : Surgery)

Clinical Professor

Masaki Kaibori【Research Fields】
In the Liver Surgery Department, we conduct research to establish safe and effective laparoscopic hepatectomy for hepatocellular
carcinoma and to reduce perioperative risk in elderly patients, as well as clinical research on the therapeutic effects of immune
checkpoint inhibitors. Our multi-institutional joint research with domestic and overseas facilities includes the development ofeffective treatment methods for hepatobiliary diseases, large-scale studies based on the analysis of big data such as NCD (National
clinical database), and the elucidation of carcinogenic factors based on comprehensive genetic analysis of hepatocellular
carcinoma and bile duct cancer. In addition, our specific clinical research investigates the effects of hydrogen on the postoperative
recovery of patients after hepatectomy. In addition to developing a new DDS (Drug delivery system) using nanofiber mesh and a
postoperative adhesion prevention material, we conduct a wide range of research. Our research includes the immunohistochemical
analysis of immune checkpoints in hepatobiliary pancreatic cancer using fluorescent nanoparticles. We also analyze thehepatoprotective effects of Chinese herbs and foods in suppressing inducible nitric oxide synthase (iNOS), which is hepatotoxic. We
examine the effects of mesenchymal bone marrow cells on post-hepatectomy and transplanted livers on liver regeneration, aiming
to prevent liver failure after liver surgery. Our clinical research on liver regeneration therapy uses stem cells to save the lives ofpatients with end-stage liver failure, and we analyze the relationship between transforming growth factor-β signal transduction andprognosis in liver cancer.
【Research Goals】
1. To understand the pathophysiology of diseases related to abdominal surgery, focusing on the liver area.
2. To understand recent advances in surgery and new research prospects.
3. To set a research topic and understand the necessary theory and previous evidence.
4. To perform statistical analysis based on experimental data.
5. To present research content appropriately.
6. To write papers on research results.
7. To obtain research funds based on research results and promote research further.

17

Research Field : Pancreatobiliary Surgery(Department : Surgery)

Clinical Professor

Sohei Satoi【Research Fields】
Basic research① Search for new targets of photoimmunotherapy for pancreatic cancer using the nCounter analysis system.
② Comprehensive analysis of the microbiome in pancreatic cancer using the ultracompact nanopore sequencing device, MinION.
③ Analysis of biomarkers that predict responses to therapies for peritoneal disseminated pancreatic cancer.
④ Determining expression profiles of adipophilin in biliary pancreatic cancer and clinical pathological examinations.
⑤ Research on the presence of cancer-related fibroblasts, cancer stem cells, and prognoses in biliary pancreatic cancer.
⑥ Research on the expression of Caspase 3 (immunostaining) and the assessment of therapeutic effects of preoperative treatments in pancreatic cancer.
⑦ Research on the expression of intermediate filaments of the nervous system, such as peripherin and internexin, as well as related
proteins, and prognosis in pancreatic neuroendocrine tumors.
⑧ Research on pathological tumor shrinkage patterns after preoperative chemotherapy/radiotherapy and prognosis in pancreatic cancer.
⑨ Examination of the association between the proportion of acinar cells in pancreatic segments and postoperative pancreatic fistula.
⑩ Pathological and genetic analysis of ascites via cyto-diagnoses during pancreatic cancer surgery.
Clinical research (representative/specific research)⑪ A multicenter, phase III randomized controlled trial to examine the usefulness of intravenous/intraperitoneal combination
administration of S-1+paclitaxel for patients with peritoneal metastasis of pancreatic cancer (advanced medical care).
⑫ A multicenter, double-blind, phase II randomized controlled trial to examine the improvement in treatment outcomes forborderline resectable pancreatic cancer due to the administration of AHCC (functional food)⑬ A multicenter phase II randomized controlled trial to examine the improvement in treatment outcomes for unresectablepancreatic cancer due to the administration of AHCC (functional food).
⑭ Intraoperative pancreatoscopy in IPMN patients (international multicenter joint research).
Many other studies are being conducted.
【Research Goals】
1. Be able to set a research agenda and develop a research plan to resolve outstanding issues
2. Learn immunogenetic approaches using clinical specimens and implement them appropriately
3. Be able to create a database from research data (including data cleaning) and conduct appropriate statistical analysis
4. Be able to carry out research appropriately as a member of a clinical research team
5. Be able to present research appropriately in Japan and abroad
6. Be able to summarize research in English

Research Field : Breast Surgery（ Department : Surgery ）Clinical Professor

Tomoharu Sugie【Research Fields】
Breast cancer is heterogeneous, as its internal kinetics of tumor growth and metastasis is determined not only by the biologicalcharacteristics of the tumor itself, but also by its interaction with immunity. In the Breast Surgery Department, we construct a tissue
microarray of triple-negative breast cancer (TNBC) to study the biology of immune and stromal cells in the tumor microenvironment
using immunohistological techniques, in collaboration with the Department of Pathology and Laboratory Medicine. Currently, we
are analyzing the relationship between the expression of biomarkers, such as PD-L1 (programmed cell death ligand-1) and PD-L2,
in tumor-infiltrating lymphocytes and stromal cells of TNBC and prognosis. Furthermore, in collaboration with Kyoto University, weare studying the molecular mechanism behind the differentiation and drug resistance of hormone receptor-positive breast cancer bygenerating breast cancer organoids from needle biopsy and surgical specimens. The construction of the breast cancer disease modelusing these organoids is expected to lead not only to the development of individualized treatments for breast cancer but also to theidentification of target molecules of new drugs.
【Research Goals】
1. To be able to understand the clinical pathology of breast cancer.
2. To understand the immuno-molecular biological mechanisms of the development, growth, and metastasis of breast cancer, as
well as biological defense mechanisms.
3. To plan and execute clinical trials based on preclinical data.

18

Research Field : Pediatric Surgery(Department : Surgery)

Clinical Professor

Takashi Doi【Research Fields】
There are many unexplained congenital diseases in pediatric surgery whose mechanisms have not been elucidated. To investigate
their causes, it is important to study embryology and fetal development. We conduct basic research that aims to understandthe etiology of typical congenital diseases by using established animal disease models. Specifically, the animal models used inour research include: ① the Hirschsprung’s disease mouse model, ② the congenital diaphragmatic hernia rat model, and ③
the umbilical hernia avian model. By using techniques such as immunostaining and RT-PCR, we perform molecular analysisof responsible genes and proteins that can cause each disease, and aim to understand congenital disease etiology in order tounderstand potential prevention methods. Furthermore, because some of the congenital diseases studied in our research involve
defective organs, we also research regenerative medicine. Specifically, as joint research with the Department of Stem Cell
Regenerative Medicine, we work to create striated muscle sheets using iPS cells. Lastly, we have initiated a basic pilot study thataims for the clinical application of an artificial biological patch for congenital diaphragmatic hernia, which has a low survival rate.
【Research Goals】
1. To understand the pathophysiology of pediatric diseases and surgical treatments.
2. To write papers in English.
3. To present at conferences in English.

Research Field : Cardiovascular Surgery(Department : Cardiovascular Surgery)【Research Fields】
Genetic Analysis of Cardiovascular Diseases with a Focus on Marfan Syndrome and Related Disorders

Professor

Tadaaki Koyama

This research field explores the genetic basis of cardiovascular diseases, with a special emphasis on Marfan syndrome and relateddisorders. These are inherited disorders that affect the elastic fibers in various tissues, leading to cardiovascular complications suchas aortic aneurysm and dissection. We use genetic panel sequencing to detect mutations in the FBN1 gene that encodes fibrillin-1,
a major component of elastic fibers, and to evaluate their pathogenicity and clinical significance. Some of the detected variants
are of unknown significance (VUS), which require further investigation and validation. We also utilize genomic omics data toidentify novel biomarkers and therapeutic targets for cardiovascular diseases. This research field provides an opportunity to acquire
advanced skills and knowledge in genetic analysis and cardiovascular surgery, and to contribute to the development of precision
medicine for cardiovascular diseases.
【Research Goals】
1. To identify and characterize the mutations in FBN1 and other genes involved in elastic fiber formation and function in patientswith Marfan syndrome and related disorders
2. To develop and validate novel biomarkers and therapeutic strategies for cardiovascular diseases based on genomic omics data

19

Research Field : Vascular Surgery(Department : Cardiovascular Surgery)

Clinical Professor

Hiroyoshi Komai【Research Fields】
Peripheral artery disease (PAD), is known to have a poor prognosis even with mild leg symptoms. In the Department of Vascular
Surgery, we study approaches to improve the prognoses of patients especially with mild PAD. We clinically examine whether thesubsequent quality of life can be improved by screening for the risk factors of heart, cerebrovascular, and other fatal arteriosclerotic
diseases, which are thought to occur even in approximately 40% of mild case patients. We also investigate the involvementof lipid-based markers, which are important risk factors in coronary artery diseases, in the development of PAD in large-scaleobservational studies. On the other hand, our studies on severe cases (chronic limb threatening ischemia) focus on early detectionof severe ischemia for prompt diagnosis and appropriate treatment. We have developed a novel method for detecting the bloodflow wave of the toes and measuring the severity of ischemia of the lower limb with ease, which is currently tested in clinicalpractice in a prospective study. In the Vascular Surgery Department, we are committed to conducting clinically applicable research,
and we aim to improve the prognoses and quality of life of patients with PAD through these studies.
【Research Goals】
1. To become knowledgeable on anatomy, physiology, pathology, and symptomatology of arterial and venous diseases.
2. To learn the treatment and surgical methods for the above diseases.
3. To accurately focus on the clinical problems of the above diseases and conduct research to solve them.
4. To disseminate research results domestically and internationally.
5. To become a leader of researchers in the same field.

Research Field : Thoracic Surgery(Department : Thoracic Surgery)

Professor

Tomohiro Murakawa【Research Fields】
We study the relationship between the expression of PD-L1 (programmed cell death ligand-1) and prognosis in lung cancer incollaboration with the Departments of Thoracic Oncology and Pathology. Aiming to clarify the relationship of PD-L1 expression intumor tissues with prognosis, and the effects of anti-PD-1 antibody treatment, we retrospectively examine the clinicopathologicalcorrelations based on the comparison of PD-L1 expression with prognosis and treatment information. Furthermore, aiming to findbiomarkers associated with pre-metastatic niches in lung cancer, we work to identify factors associated with pre-metastatic niches,risk factors for postoperative recurrence and metastasis, and cells responsible for pre-metastatic niche-related symptomatic signals
in lung cancer, through a comprehensive analysis of inflammatory signals in pre-metastatic niches in lung cancer. We are also
developing a new diagnostic method for pneumothorax, which is the second most common disease in the field of thoracic surgery
after lung cancer.
【Research Goals】
1. To understand the pathophysiology and pathology of diseases related to thoracic surgery, focusing on the lung, mediastinum, andpleura.
2. To understand the latest advances and new research prospects in thoracic surgery.
3. To set a research topic and understand the necessary theory and published data
4. To perform appropriate statistical analysis, such as survival analysis, based on research data.
5. To present research results appropriately.

20

Research Field : Research and Therapy of Brain Tumors and Central Nervous System Diseases(Department : Neurosurgery)

Professor

Akio Asai【Research Fields】
Cancer stem cells are garnering research attention as a cause of cancer recurrence and metastasis. In our department, wediscovered novel molecular targets from the cancer stem cells established from brain tumors. Thus, we are now working to identify
new biomarkers for cancer recurrence and develop therapeutic agents. We also discovered that cancer stem cells highly express
regulatory T-cell modulators and demonstrated novel data that regulatory T-cell modulators affect prognoses. Based on thesefindings, we aim to develop immunotherapy for malignant brain tumors.
We also research congenital malformations in children. Spina bifida is the most common among those disorders, and theidentification of its cause, as well as the development of its diagnosis, treatments, and prevention methods, is needed. We areworking to find gene mutations specific to spina bifida through whole-genome analysis of specimens from patients with familial
spina bifida.
【Research Goals】
1. To understand the pathophysiology and pathogenic mechanisms of neurosurgical diseases.
2. To understand the treatment methods for neurosurgical diseases.
3. To understand the pathophysiology and pathogenic mechanisms of malignant brain tumors.
4. To understand antitumor immunity.
5. To understand the characteristics of neural stem cells.
6. To learn basic techniques such as cell culture, flow cytometry, and immunohistochemical staining.
7. To acquire the ability to determine applicable research need through conference activities and literature reviews.
8. To acquire the ability to set testing methods necessary for solving the problem.
9. To gain statistical knowledge for testing experimental data.
10. To acquire the ability to present research content appropriately.
11. To acquire the ability to publish research content as papers.

Research Field : Orthopedic Surgery（ Department : Orthopedic Surgery ）Professor

Takanori Saito【Research Fields】① Ricoh (Tokyo, Japan) has developed a magnetospinography system that measures biomagnetism generated by neural activity anddetermines the site of neuronal injury. In 2019, our department constructed a new research facility on the premises of KANSAIMEDICAL UNIVERSITY to conduct clinical research on the spinal cord and peripheral nerve disorders as joint research between
senior Saito, Ph.D and the company.
② Implant infection is a major problem of general postoperative complications. Bacteria may not be detected by current culture
tests if antibacterial agents have been administered or if the bacteria are anaerobic. Our department has established a method
suitable for the identification of bacterial genes using next generation sequencing and is conducting research for its clinicalapplication.
③ Intraoperative spinal cord monitoring is essential in cases in which myelopathy is a concern during surgery, but an optimalmeasurement method has not been established. There are several measurement methods for nerves, including motor and sensory
nerves, and their reproducibility and sensitivity vary depending on the depth of anesthesia, the number of stimulations, and thedisorder of the spinal cord itself. The Department of Orthopedic Surgery at Kansai Medical University, which is accredited as an
educational facility for intraoperative monitoring and visited by many physicians and medical technicians for training every year,
is working on new methods of intraoperative spinal cord monitoring.
【Research goals】
1. To understand the structures and functions of bones, joints, ligaments, peripheral nerves, and spinal cord.
2. To understand the concept of the locomotorium.
3. To learn basic experimental techniques.
4. To set a research topic and understand the necessary theory and published data.
5. To perform statistical analysis based on experimental data.
6. To present research content appropriately.

21

Research Field : Physical Medicine and Rehabilitation(Department : Physical Medicine and Rehabilitation)

Professor

Kimitaka Hase

【Research Fields】
Based on motor learning theory and clinical data mining, we aim to optimize rehabilitation therapy for the reconstruction of humanactivities. Treatment strategies in our studies include the use of rehabilitation robots, cognitive function training using mixed reality
technology, and motor learning that comprehensively processes sensory noise (differential training). We quantify the effects ofsensory-motor integration induced by these therapeutic tasks and determine the factors involved in the changes through the useof machine learning. By visualizing the performance formed by the interference of complex subsystems contained in individuals,
tasks, and environments, we clarify problematic constraints and optimize the process of treatment policy decision-making. The
treatment task that is developed by applying dynamic systems theory and utilizing clinical data mining supports the developmentof rehabilitation medicine that embodies “personalized medicine,” departing from a “one size fits all solution.” Such results will
positively impact the global medical community, contributing to a care system that prevents the need for long-term care andextends healthy life expectancy.

【Research Goals】
1. To understand therapeutic strategies for the improvement of activities.
2. To understand the concept of motor learning in disability medicine.
3. To learn basic techniques for functional evaluation and rehabilitation treatment.
4. To set a research topic and understand the necessary theory and published data.
5. To be able to perform statistical analysis based on experimental data.
6. To be able to present research content appropriately.

Research Field : Plastic and Reconstructive Surgery(Department : Plastic and Reconstructive Surgery)【Research Fields】
1) Adipose-derived Stem Cells (ASCs) are obtained from subcutaneous fat, and their effectiveness as regenerative medicine in thefield of plastic surgery has become clear. We perform molecular biology analyses of cultured ASCs in our basic research, while
our clinical research applies them to breast reconstruction after the resection of breast cancer.
Professor

Natsuko Kakudo

2) Autologous platelet-rich plasma (PRP), which is produced by the centrifugation of collected blood, contains platelets inabundance. Because a large amount of various growth factors derived from autologous platelets is contained in PRP, we aim to
apply PRP to wound treatment in decubitus and intractable ulcers.
3) Elucidation of the mechanism of keloid development and the development of its treatment methods. We analyze cells isolated
from keloid tissues and examine the effects of tension on cells.
4) Tissues can be maintained in a below-freezing electric field environment, which lowers cellular metabolism and prevents cellular
deterioration due to thawing. We study organ preservation using a below-freezing electric field environment.
1) and 2) have been approved for clinical use under the Act on the Safety of Regenerative Medicine, and we are developing clinicalapplication at our university hospital.
【Research Goals】
1. To be able to understand the structures and functions of the skin, soft tissues, nerves, blood vessels, bones, and cartilage.
2. To understand the concepts of functions, forms, and color tones that make up and support the surface of the human body.
3. To be able to formulate a meaningful research theme related to clinical treatments in plastic surgery and develop a concrete
experimental plan.
4. To learn basic techniques of processing methods for the collection and analysis of biological tissues.
5. To be able to find important events and previous reports related to the research theme and use them as a basis for research
direction.
6. To present research content and results appropriately.

22

Research Field : Dermatology(Department : Dermatology)【Research Fields】
Examination of the mechanism of granuloma development using iPS cells derived from patients with therare disease Blau syndrome (Figure 1)

Professor

Hideaki Tanizaki

We are analyzing the mechanism of neutrophil-mediated acute inflammation and delayed inflammation
typified by granuloma formation by establishing iPS cells from patients with Blau syndrome and inducing
their differentiation into monocyte lineages.

(Figure 1)(Figure 2)

Examination of the migration of activated basophils from peripheral blood to skin (Figure 2)
We would like to find new insights of pathophysiology of urticaria from the viewpoint that in idiopathic urticaria,
basophils infiltrate the skin lesion from the peripheral blood and are involved in the formation of wheals.

(Figure 3)

Analysis of natural moisturizing factors in the stratum corneum with and without the use of topicalmoisturizers in atopic dermatitis (Figure 3)
Focusing on natural moisturizing factors that play a central role in the barrier function and water retentionof the skin, we aim to identify the cause of barrier dysfunction in diseases through functional analysis ofmoisturizing factors and percutaneous water evaporation and pH.

(Figure 4)

Examination of the risk of developing cardiovascular events associated with chronic skin inflammatory
diseases (Figure 4)
We work to elucidate the pathophysiology of general complications associated with chronic skin inflammation, centering on psoriasis vulgaris. Focusing
particularly on lifestyle-related diseases and vascular lesions, we also analyze the effects of the administration of biological products using donated cadavers.
【Research Goals】
1. To understand the structure and function of the skin.
2. To understand the pathophysiology of the diseases studied in our research and related diseases.
3. To learn basic techniques related to a research topic.
4. To perform statistical analysis based on experimental data.
5. To present research content appropriately and write papers.
6. To provide dermatological medical care through research and study.

Research Field : Urology and Andrology(Department : Urology and Andrology)【Research Fields】
Our laboratory’s main research theme is developing surgical education based on scientific analyses of surgery. For example, wehave measured and analyzed the force applied to the tip of forceps used in laparoscopic surgery.
Professor

Hidefumi Kinoshita

In laparoscopic surgery, surgeons cannot easily feel the force applied to the forceps tip, which may cause unexpected organ
damage during the surgical dissection procedure. Although skilled surgeons can easily perform dissection based on experience, it is
not easy for junior surgeons, and it is difficult to verbally instruct junior surgeons how to perform the procedure.
We hypothesized that showing the direction and magnitude of the acting force objectively would have a high educational effect,
allowing junior surgeons to better understand the procedure. In our laboratory, we created a system that can measure acting force(vertical and horizontal forces) during dissection procedures, and analyzed the force applied to the forceps tip by surgeons ofdifferent skill-levels during dissection. The results indicated that skilled surgeons first apply a vertical force with a weak horizontal
force, and then increase the horizontal force while reducing the vertical force. On the other hand, junior surgeons apply horizontal
and vertical forces at the same time as they increase the forces from the start to end of the dissection.
The importance of such a method of scientifically analyzing surgeries is expected to increase in terms of understanding surgicalprinciples, building the foundation of surgical education, and flattening the learning curve for technical acquisition.
【Research Goals】
1. To classify and outline diseases that occur in the adrenal glands, kidneys, and urogenital system.
2. To outline the onset and exacerbation of the diseases, as well as their molecular mechanisms.
3. To outline typical methods in life science research (such as genetic and cell biology experiments).
4. To give an outline of historical changes of major urological diseases, including their concepts, origins, and treatments.
5. To extract unsolved problems, formulate hypotheses, formulate research plans for solutions, and execute them.
6. To present research results at conferences, as well as to publish them as papers.
7. To outline of research ethics.

23

Research Field : Ophthalmology and Visual Science(Department : Ophthalmology)

Professor

Kanji Takahashi【Research Fields】
In the Laboratory of Ophthalmology, we study the mechanisms of age-related macular degeneration and pathologicalneovascularization in diabetic retinopathy, and clinically apply the results. The experimental model of choroidal neovascularizationis generated by laser photocoagulation, while the hypoxic retinopathy model similar to retinopathy of premature infants is generated
by exposing experimental animals to high oxygen concentrations. In our basic research, we have efficiently reproduced these
diseases with experimental model animals typically used in our laboratory for many years. Although our research previously
focused on histology using electron and optical microscopes, we have been actively adopting molecular and cell biology
approaches in recent years. Particularly, we are one of the laboratories with the largest numbers of patients and treatments forage-related macular degeneration, and are considered a center for the treatment of age-related macular degeneration. Taking
advantage of this, we have established an ideal basic research-clinical cycle, in which we raise questions based on various clinicalexperiences, formulate a research plan to find their answers experimentally, conduct research by making full use of experimental
animals and cells, and return to clinical practice to apply the obtained knowledge.
【Research Goals】
1. To be able to understand the structures and functions of the visual organs.
2. To understand the concept of intraocular neovascularization.
3. To learn basic techniques for generating the animal model of intraocular neovascularization and for cell culture.
4. To set a research topic and understand the necessary theory and published data.
5. To be able to perform statistical analysis based on experimental data.
6. To be able to present research content appropriately.

Research Field : Otolaryngology, Head and Neck Surgery(Department : Otolaryngology, Head and Neck Surgery)

Professor

Hiroshi Iwai

【Research Fields】
Despite the increasing number of patients with age-related hearing loss in developed countries, a preventive method for this type ofhearing loss has not been established. We have shown that hearing loss progression in a model is prevented by systemic immune
modification (rejuvenation) treatments, including bone marrow transplantation, thymic transplantation, and lymphocyte inoculation
with young/fetal mice donors. We aim to understand this, establish clinically compliant immunomodulatory treatments, andexamine their application to humans.
Our research also focuses on understanding eosinophilic airway inflammation, currently an intractable disease. We found a novel
subtype of eosinophils present at the site of inflammation, and investigate novel biomarkers that we expect to be involved in thepathogenesis of activated eosinophils. We are pioneering a new field called “Airway Medicine,” a field that comprehensively viewsthe entire airway from pathology to treatment.
【Research Goals】
1. To understand the anatomical structures and functional roles of the otology area, the upper airway (nasal/paranasal cavities, oralcavity, and pharynx) and lower airway, and the head and neck surgery area.
2. To learn handling and analysis methods of human clinical samples and data.
3. To learn animal handling based on animal welfare, as well as generation and analysis of disease mouse models.
4. To learn basic molecular biology techniques for analyzing samples.
5. To read original English papers.
6. To objectively evaluate experimental data using statistical methods and establish the ability to prepare presentations and papers
in English.
7. To acquire an international sense through overseas joint research and presentations at international conferences.
8. To conduct research in collaboration with researchers inside and outside the university.
9. To plan and execute research in accordance with laws and regulations, such as codes of ethics and guidance on dangerous
material disposal.

24Research Field : Radiology(Department : Radiology)

Professor

Noboru Tanigawa【Research Fields】
1. Diagnostic Imaging
1. Based on image analyses of malignant tumors (stomach, prostate, rectal, and lung cancers) using multidetector computerized
tomography (CT), 3-Tesla magnetic resonance imaging (MRI), and similar, we study the localization and depth diagnoses oftumors, their infiltration into surrounding tissues, degree of tumor differentiation, and correlation with prognoses, utilizing
excised pathological specimen.
2. Nuclear Medicine
1. We investigate the usefulness of concurrent chemotherapy and RI(Radio Isotope) treatment targeting cancer, and aim to develop
imaging and therapeutic agents for RI-labeled lipiodol. In addition, we focus on a clinical understanding of pathologicalconditions, construction of efficient diagnostic methods, and aim to predict treatment effects for diseases like Parkinson’s
diseases ( i.e. dopamine transporter imaging), head and neck tumors (prediction of prognosis with F-18 FDG PET), lung cancer(prediction of the efficacy of immune checkpoint inhibitors), prostate cancer (oral Ra-223 therapy), and malignant lymphoma(radioimmunotherapy).
3. IVR(Interventional Radiology)
1. Using the animal imaging room, we study embolic agents, biological uses of nano-microbubbles, novel lymphatic IVR
techniques, CT fluoroscopy IVR support systems, and the development of antithrombogenic and antibacterial catheters.
4. Radiation Therapy
1. We aim to clarify the usefulness and potential problems of high-precision radiation therapies, such as intensity-modulated
radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT), for various malignant tumors through basic experiments
and clinical trials.
【Research Goals】
1. To understand the physical and biological properties of radiation.
2. To understand the concepts of radiodiagnosis and radiation therapy.
3. To learn fundamental techniques related to basic and animal experiments using radiation.
4. To set a research topic and understand the necessary theory and published data.
5. To perform statistical analysis based on data.
6. To present research content appropriately.

Research Field : Radiation Oncology（ Department : Radiology ）Clinical Professor

Satoaki Nakamura【Research Fields】
In the Radiation Oncology Department, we provide curative treatment for a wide variety of malignant tumors and palliative
treatment for cancer-related symptoms using the latest treatment equipment. Through these treatments, we also focus on the trainingof radiation oncologists and medical physicists.
The department also conducts a wide range of basic and clinical research rooted in the practice of radiation therapy as follows:
Clinical research: In the clinical practice of cancer radiotherapy, we are promoting clinical trials for head and neck cancer andpancreatic cancer using high-precision radiotherapy equipment, optimizing high-dose-rate interstitial radiotherapy for prostatecancer and gynecological cancer, and developing a system that can determine the indication for radiotherapy for bone metastases.
Medical Physics: We are conducting research on the development of radiotherapy using computer science, including theautomation of image processing and radiotherapy planning using artificial intelligence, and the development of new analysis
methods to comprehensively analyze image features obtained from medical images and to clarify the relationship between thefeatures and clinical information.
In this way, we hope to provide state-of-the-art radiotherapy and at the same time create tomorrow's cancer treatment.
【Research Goals】
1. To understand the physical and biological properties of radiation oncology.
2. To understand the concepts of radiation therapy.
3. To set a research topic and understand the necessary theory and published data.
4. To perform statistical analysis based on data.
5. To present research content in English.

25

Research Field : Obstetrics and Gynecology(Department : Obstetrics and Gynecology)【Research Fields】
The Department of Obstetrics and Gynecology is the only clinical department involved in the birth of new life, supporting women and thefuture of Japan, and is a highly attractive area with multiple of research themes. Our department has established a new developing researchstyle with close collaboration and cooperation in the fields of perinatal medicine, reproductive endocrinology, and gynecological oncology.
Professor

Hidetaka Okada

We analyze the functions of reproductive organs and cells and examine reproductive organ tumors by incorporating molecularbiology techniques into immunohistochemical staining and cell culture. Particularly, in uterine research, which focuses on the central
tissue of reproductive functions, we study the contraction mechanism of the uterine muscle to prevent miscarriage and prematurebirth, focusing on the effects of various drugs and external factors. In addition, our research on the functions of the endometrium,
which is the key to the establishment of pregnancy, aims to develop better diagnostics and treatments of infertility (implantation failure)
and recurrent miscarriages through molecular and genetic analysis of the mechanism of sex-hormone mediated cell differentiation.
Our clinical research focuses on developing a new method of lymph node dissection to reduce
lymphedema, which is one of the complications. Furthermore, regarding new diagnoses andtreatment methods for gynecological malignant tumors, we aim for practical application ofnavigation surgery for endometrial and ovarian cancers, as well as early minimally invasive
treatment for cervical dysplasia.

We discovered seminal evidence that the transcription factor HAND2, involved in the functions of the endometrium, is strongly
induced in the nucleus during the process of decidualization (differentiation) of cultured human endometrial stromal cells (pictured
above).
【Research Goals】
1. To understand the structures and functions of the uterus and ovaries.
2. To learn basic techniques related to molecular and genetic analyses and tissue culture.
3. To set a research topic and understand the necessary theory and previously published data.
4. To be able to perform statistical analysis based on experimental data.
5. To be able to present research content appropriately.
6. To be able to publish research results as scientific papers.

Research Field : Anesthesiology and Critical Care Medicine（ Department : Anesthesiology ）Professor

Takahiko Kamibayashi【Research Fields】
Platelets, in addition to their primary role in hemostasis and coagulation, are involved in the immune and inflammatory systems.
Particularly, microparticles less than 1 µm in size released from platelets by platelet activation were first reported as “plateletdust” (platelet waste) in 1967, but recent studies have shown that these microparticles are important factors in the pathogenesisof inflammatory conditions through their interactions with other blood cells and vascular endothelial cells. Focusing on theeffects of cardiopulmonary bypass during heart surgery, we promote clinical and basic research on the mechanism by which
various perioperative stress reactions affect platelet function, blood coagulation and inflammatory response and their application
to new therapeutic methods. Additionally, we are conducting basic research on organ protection in brain-death model animals
and on hemodynamics using a myocardial-ischemia model. We also conduct clinical research on changes in brain waves at thesedation level, the development of sedation monitors, as well as outcome studies using medical statistics and medical big data.
Furthermore, our joint translational research with the Department of Innovative Regenerative Medicine of the Graduate School at
Kansai Medical University serves as a bridge between basic research and clinical practice.
【Research Goals】
1. To understand the pathophysiology of the invasive response of a living body.
2. To understand measures to control invasive immune responses.
3. To set a research topic to be carried out and understand the necessary theory and previously published data.
4. To carry out experiments and interpret their data by incorporating statistical analysis and other methods.
5. To present research content appropriately and discuss with trainers and other researchers based on evidence.
6. To learn and execute the process of compiling and publishing research results as papers.

26

Research Field : Anesthesia Pharmacology（ Department : Anesthesiology ）Clinical Professor

Satoshi Hagihira【Research Fields】
Anesthetics cause loss of consciousness and memory, which reversibly recover after removal. Overly shallow anesthesia causes
intraoperative awareness, while deep anesthesia causes delayed awareness and various perioperative complications. Therefore,
maintaining an appropriate anesthetic concentration is highly important in clinical anesthesia. In addition, because current
anesthetics do not have an analgesic effect, balanced anesthesia in combination with analgesics is commonly used. It is clinicallyimportant to understand how different combinations affect various effects of anesthesia due to the interaction between anesthetics
and sedatives.
Thus, aiming to provide optimal anesthesia for each patient, we are investigating various methods, such as using pharmacokinetic
knowledge and determining the effect of anesthesia based on brain waves. Also, to examine the effects of intravenous anesthetics indetail, we control the syringe pump with a computer to maintain the administration records of various anesthetics and sedatives, toperform pharmacokinetic simulations, and record brain wave data concurrently. Therefore, our research facilitates clinical practice.
【Research Goals】
1. To understand the pharmacokinetics of various anesthetics.
2. To understand how to read the waveform of brain waves of patients under anesthesia.
3. To understand the methodology of various brain wave analyses.

Research Field : Acute Critical Medicine, Traumatology and Disaster Medicine（ Department : Emergency and Critical Care Medicine ）Professor

Yasuyuki Kuwagata【Research Fields】
Our emergency medicine laboratory on the 8th floor of the university building is equipped with a physiological experiment system,
which uses a rabbit model of variable cardiac output to analyze the oxygen delivery/consumption relationship of an individual forthe investigation of the nature of various pathological conditions. In our research, we generated a shock model with attenuating
peripheral vascular resistance caused by the expression of pathological mediators, which mimics human septic shock, compared
it to an equivalent attenuation of peripheral vascular resistance generated by external administration of vasodilatation mediators.
Our recent publication demonstrated that, while the former has a pathological oxygen supply dependency in which oxygen
consumption decreases depending on the decrease in oxygen delivery, the latter maintains a constant oxygen consumption level
regardless of the amount of oxygen delivery. These results suggest that pathological decreases in oxygen consumption are caused
not only by mere attenuation of vascular resistance but also by abnormal blood flow distribution at the site where pathologicalmediators are expressed.
(Our findings were published in the Acute Medicine and Surgery, an English journal of the Japanese Association for Acute
Medicine)【Research Goals】
1. To explain the pathophysiology of severe emergency cases seen in the Department of Emergency Medicine by aggressologicaltheory and propose countermeasures.
2. To know the history and current status of emergency and disaster medicine and to be able to propose improvement methods
needed for the next generation.

27

Research Field : Dentistry and Oral Surgery(Department : Oral Care Center)

Center Professor

Yuka Kojima【Research Fields】
In our department, we are conducting research on medicaton, novel surgical methods and image diagnosis with the aim ofelucidating the causes and pathology of patients suffering from Medication-related osteonecrosis of the jaw (MRONJ). We are also
conducting research with the aim of establishing preventive and therapeutic methods for adverse events in the perioperative period.
Through these studies, we provide education to help medical professionals who fully understand the function and anatomy of theoral cavity, who can formulate their own research plans, and who aim to establish treatment methods.
【Research Goals】
1. Thoroughly understand the functions and anatomy of the oral cavity areas.
2. To be able to practice perioperative oral care.
3. Understand the pathogenesis of medication-relation osteonecrosis of the jaws (MRONJ) and its treatment.
4. To be able to search past papers and understand what has been elucidated to date.
5. Learn how to handle human clinical samples.
6. Learn the basic techniques for analyzing samples.
7. To be able to perform statistical analysis and evaluate the data.
8. Learn how to properly manage and dispose of samples and manage data.
9. To be able to summarize research content, give appropriate presentations, and write English papers.
10. To be able to plan and carry out research based on laws and ethical regulations.
11. Acquire international sensibilities through presentations at international conferences.

Research Field : Clinical Laboratory Medicine(Department : Clinical Laboratory Center)【Research Fields】
The main research topics of our department are:Center Professor

Akira Kanda

1.Development of new testing equipment
1) New detection system using ultrasonic waves
2) Novel comprehensive management system in the clinical laboratory by using flow line analysis with AI technology
3) New immunological and biochemical tests system
2.Basic research
1) Understanding of a mechanism of airway inflammation, especially “United airway disease”.
2) New therapeutic strategy and targe compound upon airy inflammation
2) Discovery of new biomarkers for allergic airway inflammation
3) Clarify a functional role of eosinophils using original genetical modified mice4) Development of new compound upon olfactory dysfunction using original system
We support to master's and doctoral course students in order to obtain knowledge technology about measuring apparatus andphysiological function testing, including quality control, testing procedure, and validity of examination. Students learn research
ethics, acquire the knowledge necessary for research, collection technique, methods, analyze data, and writing technique ofmanuscript in our laboratory. Then, final goals are that students independently make experimental planning, perform experiments,and submission of paper by themselves; detail goals are described below.
【Research Goals】
1. Compliance with ethic and guidelines
2. Cooperation with Other Researchers
3. Understanding for research environment, obtaining research grants, and manner in the laboratory
4. Improving skills; experimental planning, experimental protocol, bibliographic survey, reading ability of research science paper,and application of patent
5. Acquisition; experimental techniques, analysis skills, writing research papers, manner of submission to science journal and peer
review, establishment of research environment, and obtaining grants
6. Leadership; teaching next generation researchers

28

Research Field : Health Science(Department : Health Science Center)【Research Fields】
The Laboratory of Health Science conducts multifaceted research related to exercise, psychology, nutrition, sports medicine(orthopedics and cardiovascular medicine), and health, and it covers a wide range of health-related areas, such as hemodynamics,
metabolism, skeletal muscle function, arteriosclerosis, anti-aging medicine, and brain function. We also carry out behavioral
medicine for practicing clinical medicine, evaluation of daily continuous biological information using ICT, and research andDistinguished Professor appointed by
the Chairman of the Board
development of intervention programs using wearable sensors and management applications. The data are cross-sectionally and
Yutaka Kimura
longitudinally examined in collaboration with the Health Science Center of the university hospital and related facilities.
Ultimately, we aim to open the world’s first health business MBA course by making full use of these research programs for theconstruction of a cost-effective intervention system, collaboration with specialized medical institutions, community medicine,
fitness facilities, and government, as well as research and develop business models.
Main Research Themes:
1. Research the effects of exercise by skeletal muscle function,
circulatory dynamics, metabolic factors, and autonomic
nervous function.
2. Understanding the relationship between obesity and brain
function, cognitive behavioral therapy, and food behavioral
science.
3. Development of new health indicators and intervention systems
by analyzing biological big data using ICT wearable biosensors.

【Research Goals】
1. To understand the scheme of health-related medicine.
2. To understand the basics of exercise, nutrition, and psychology.
3. To understand behavioral medicine focusing on cognitive behavioral therapy.
4. To set a research topic and understand the necessary theory and previously published data.
5. To be able to perform statistical analysis based on experimental data.
6. To be able to present research content appropriately.

Research Field : Mathematical Sciences(Department : Mathematics)

Professor

Tomoki Kitawaki【Research Fields】
Our research aims to deepen scientific understanding and improvement by abstractly modeling concrete phenomena,
mathematically analyzing based on logic, and positively impacting the global community through math. We also study biostatistics,
which has diversified in recent years.
The role of mathematics in the medical world is foster improvement, by abstractly modeling concrete phenomena, mathematicallyanalyzing based on logic, and positively impacting the global community. There are a wide variety of medical research subjects.
Thus, to apply mathematical methods to research on any subject, it is important to express the actual data and biological signals
with a mathematical model that is physically and mathematically meaningful to pursue the principle. The mathematical models
used for such mathematical analysis are diverse depending on the research subject, and there are various methods of medical
statistics, which have diversified in recent years.
Therefore, with the utilization of such mathematics in the medical field in mind, the Laboratory of Mathematics aims to improve theability to use mathematics as a tool, which can be used for a wide range of purposes from basic studies to clinical applications, andwe hope to give back to the entire university community through our endeavors. Additionally, with the increasing importance of
medical statistics in clinical research, we will develop research support activities that apply medical statistics.
【Research Goals】
1. To acquire a systematic knowledge of mathematical models.
2. To acquire the ability to promote research independently.

29

Research Field : Cell Biology（ Department : Biology ）Professor

Shinji Hirano【Research Fields】
The human central nervous system, consisting of complex neural circuits, performs higher-ordered neural activities including
emotions and memory. Cell adhesion molecules protocadherins, which have a diverse variety, are specifically expressed in the
nervous system, and they are thought to be responsible for complex cell-cell interactions, such as the formation of neural circuits
and synapses. Research on protocadherins is getting attention as it has been reported in recent years that some protocadherin
genes are associated with psychiatric disorders, including autism. In the Laboratory of Biology, we study the roles of protocadherin
molecules in neural circuit formation and higher brain function at the molecular and cellular levels using knockout mice lacking
protocadherin genes. We have found that the genes for protocadherins 1 and 9, which are related to autism, are specifically
expressed in the hippocampus and amygdala and that knockout mice lacking these genes have abnormal emotional behaviors. We
aim to elucidate the molecular mechanism of protocadherin-mediated emotional behaviors and explore the relationship withinhuman psychiatric disorders in the future.
【Research Goals】
1. To understand cell adhesion molecules.
2. To understand neural circuit formation and neural function.
3. To learn basic techniques related to cell and developmental biology.
4. To set a research topic and understand the necessary theory and previously published data.
5. To perform statistical analysis based on experimental data.
6. To present research content appropriately.

Research Field : English for Medical Purposes Education(Department : English)

Professor

Raoul Breugelmans【Research Fields】
English education at healthcare universities is premised on the "acquisition of the English skills needed by medical professionals." The
Department of English, therefore, conducts research on the skills and knowledge that physicians and other healthcare professionals
need in order to function using English at different stages in their careers, as well as the most effective ways of acquiring, teaching
and assessing those skills and knowledge sets from the perspectives of applied linguistics, pedagogy and publication science.
Main research topics
English for medical purposes (EMP) pedagogy and assessment
From the perspectives of applied linguistics and pedagogy, we are working toward the development and validation of various EMP
teaching and assessment methods. We also aim to develop and validate a program evaluation and quality control mechanism toverify, based on various indicators, whether the set goals for EMP education are actually achieved at the time of graduation. Our
long-term aim is to standardize the educational objectives, teaching methods, and assessment methods of EMP education.
Linguistic analysis of English for medical purposes
We are conducting research to elucidate the nature of English as it is used in various genres in the medical field using linguistic
methods such as genre analysis, discourse analysis, conversation analysis, and corpus analysis, with the aim of applying the results
to the development of more effective EMP education.
International medical communications research
Also referred to as publication science or journalology, international medical communications research is a field that deals withvarious aspects of the dissemination of information in medicine, such as the reporting of biomedical research results in journals
and at academic conferences. Research topics include the peer review system, publication ethics, publication bias, researcher andjournal evaluation metrics, and reporting guidelines and recommendations.
【Research Goals】
1. Be able to develop EMP teaching methods and evaluate their educational effectiveness2. Be able to develop EMP assessment methods and evaluate their validity and reliability
3. Be able to use linguistic methods to systematically identify the characteristics of EMP
4. Be able to explain all aspects of the written and oral dissemination of information in medicine

30Research Field : Medical Informatics(Department : University Information Center)

Associate Professor

Toshiaki Nakano【Research Fields】
The main research themes in the Medical Informatics Department are cooperation among facilities in clinical informationexchange, structured and unstructured clinical data processing, and improvement in rationalization and availability of clinicalinformation infrastructure. We also participate in a research project that integrates various fields related to these themes.
While researching the effective use of accumulated medical records, including electronic medical record systems, we are also
investigating the processing of structured data. Moreover, our research also examines the diagnostic support and learning support
systems using the diagnostic imaging knowledge base based on semantic web technology. In addition to medical support resistantto system failures and disasters, as well as networks (wired and wireless) for connecting to various off-campus clinical information
databases, we are investigating the construction and operation of information infrastructure, including power supply and system
virtualization, as well as the utilization of information resources using smart devices under these infrastructures.
【Research Goals】
1. To explain the significance and issues of medical information systems, including clinical information systems, based on the
results of analysis of the current situation.
2. To understand the needs of medical information systems.
3. To explain the skills and knowledge necessary for setting, constructing, and evaluating medical information systems, as well as
their problems and issues.
4. To formulate, prepare, execute, and evaluate research plans in areas like standardization of clinical information, reformation of
information infrastructure, and application of natural language processing to medical care.
5. To play a role in the development of medical information technology as a researcher or engineer in a way that impacts society atlarge.

Research Field : Medical Behavioral Science(Department : Psychology)

Professor

Etsuyo Nishigaki【Research Fields】
Our research focuses on health and clinical psychology; specifically, the modification of health behaviors utilizing coaching
psychology, psychological and physiological changes by practicing mindfulness, focusing, and the creation of stress management
programs using various information and communication technology (ICT). Our graduate students are expected to pursue theirresearch actively and independently regardless of these themes.
For undergraduate education, our professors and part-time lecturers, are in charge of subjects such as psychology, behavioral
sciences, counseling and coaching, and mindfulness training, as well as courses at the Faculties of Nursing and Rehabilitation.
【Research Goals】
1. To be able to understand the main concepts of health, clinical, and coaching psychology.
2. To learn questionnaire survey methods, psychological experimental methods, and psychological interview techniques.
3. To practice medical coaching.
4. To perform and interpret the psychological tests necessary for research.
5. To perform statistical analysis appropriately based on research data.
6. To present research results at international conferences.
7. To summarize research results and publish them as academic papers.

31

Research Field: Medical Education(Department: Center for Health Professions Education)

Center Professor

Katsumi Nishiya【Research Fields】
Our program aims to nurture researchers who understand the fundamentals of world-standard medical education, who can grasp
educational theory through educational practice, who can collect and analyze data necessary for medical education research, andwho can formulate their research plans. Our program deals with research related to medical education as well as various area of
medical professions education.
【Research Goals】
1. To be able to understand basic theories of medical education.
2. To be able to practice education based on the theories of medical education
3. To be able to understand and utilize research methods in medical education
4. To be able to plan and carry out medical education research
5. To be able to present research details appropriately

32

MEMO

MEMO

Kansai Medical University

2-5-1 Shin-machi, Hirakata City, Osaka 573-1010 Japan
TEL： 072-804-0101 FAX： 072-804-2344

Published in January 2024