Saraya Co., Ltd.
NORTH AMERICA / SOUTH AMERICA

Headquaters

2-2-8 Yuzato, Higashisumiyoshi-ku, Osaka 546-0013 Japan
Phone: +81-6-6703-6336

Best Sanitizers, Inc.

Goodmaid Chemicals Corporation Sdn. Bhd.

Best Sanitizers Kentucky Factory

PT. Salim Saraya Indonesia

Saraya International, Inc.

Saraya Myanmar Co., Ltd.

Saraya USA, Inc.

Taiwan Saraya Hygiene Co., Ltd.

Chagaroot, Inc.

Saraya International (Thailand) Co., Ltd.

Saraya Natural Products Co., Ltd.

Saraya MFG. (Thailand) Co., Ltd.

URL: https://www.bestsanitizers.com

URL: https://www.saraya.tw

URL: https://www.saraya-thailand.com

URL: https://chagaroot.com

URL: https://sarayamfgthailand.com

Saraya Hygiene de Mexico S.A. de C.V.

Saraya Greentek Co., Ltd.
URL: https://www.saraya.vn

Saraya Brasil Ltda

Saraya Greentek Hanoi Office

Saraya Australia Pty Ltd.
Saraya New Zealand

URL: https://www.saraya.co.nz

URL: https://www.saraya.vn
EUROPE

URL: https://www.saraya.com.au

Saraya (Cambodia) Co., Ltd.

URL: https://www.saraya-europe.com/pl

Saraya (Shanghai) International Trading Co.,Ltd.

Saraya Germany GmbH

Saraya (Taixing) Manufacturing Co.,Ltd.

Saraya CIS LLC.

Saraya (Dongguan) Hygiene Products Co., Ltd.

URL: https://saraya-cis.ru
https://saraya-shop.ru

Guilin Saraya Biotech Co., Ltd.

Saraya Ukraine LLC.

URL: http://www.sarayaguilin.com.cn

URL: https://saraya-shop.com.ua
https://saraya.com.ua (Coming soon)

Saraya Mystair Hygiene Pvt. Ltd.
URL: https://sarayamystair.in

Saraya Korea Co., Ltd.

URL: https://www.sarayakorea.com

Saraya Hygiene Malaysia Sdn. Bhd.
Saraya Glove Industries Sdn. Bhd.
Saraya Goodmaid Sdn. Bhd.
URL: https://www.goodmaid.net

AFRICA/MIDDLE EAST

Shinva Medical Biotechnology Co., Ltd.

Yangzhou Saraguard Medical Supplies Co., Ltd.

Saraya Medtech SAS

Saraya Poland Sp.z o.o

URL: https://www.saraya.com.cn

URL: http://www.saraya.hk

URL: https://www.saraya-europe.com/fr

URL: https://www.saraya-europe.com

Saraya (Shanghai) Biotech Co., Ltd.

Saraya (Hong Kong Sales) Co., Ltd.

Saraya Europe SAS

Saraya Co., Ltd. Europe

URL: https://saraya-cambodia.com

Saraya HongKong Co., Ltd.

International

URL: https://www.goodmaid.net

URL: https://www.lakanto.com

Saraya Wellness Products Co., Ltd.

2024

URL: https://saraya.world/

URL: https://www.sarayamexico.com

ASIA PACIFIC

E-mail: hands@global.saraya.com

Saraya Manufacturing (U) Ltd.

Department of Healthcare-Associated Infection in the Post-Epidemic Era
Gao Min, Chi Naixun, Zhang Gangyu, Jiang Xiaoyan, Mu Siyu, Qi Yong

URL: https://saraya.ug

Saraya Beauté et Santé
Saraya Middle East for Industrial Investment J.S.C.
URL: https://saraya.me

Saraya Egypt For Medical Products
Saraya Middle East Trading DMCC
URL: https://saraya.me

Saraya Kenya Co., Ltd.
URL: https://saraya.co.ke

Please accesss here tocontact each global office

HosCom International readers,
your comments and opinions are always welcome.
Please share your thoughts with us by scanning the QR code.

Case Study
Promoting hand hygiene with unique ideas
SARAYA Activity Report・Participation in the 7th International Conference
on Prevention and Infection Control (ICPIC)
・SARAYA-Sponsored Event:New York opera performance of Semmelweis

SARAYA Healthcare News
Risk factors for postprandial hyperglycemia and the use of low-GI foods

1World Information
The Positioning of and Challenges for the Administration Department of Healthcare-AssociatedInfection in the Post-Epidemic Era
Gao Min, Chi Naixun, Zhang Gangyu, Jiang Xiaoyan, Mu Siyu, Qi Yong
The Healthcare-Associated Infection Administration Office of the Second Affiliated Hospital of Harbin Medical University

Background
The Administration Department of Healthcare-Associated Infection (ADHI),
established with the intention of controlling healthcare-associated infection(HAI) and ensuring patient safety. Combined with clinical work, upholding
control (IPC) system suitable for the development of hospitals was established.
clinical work, the ADHI has always had the role of a rear guard, in charge ofmonitoring infection levels in hospitals and developing the HAI administration
system. Since the outbreak of the atypical pneumonia (SARS) pandemic
in 2003, the functional role of the ADHI has evolved from that of a single
backstage monitor to that of a frontier unit with multisectoral collaboration,
which also carries out initial research into a regionalized IPC system. The
sudden outbreak of the novel coronavirus (COVID-19) in late 2019 and thesubsequent global pandemic led the ADHI to the next level of development.

The Functions and Positioning of the
ADHI in Times of Epidemics
With COVID-19, humanity experienced the worst global public healthemergency since World War II. In the early stages of the outbreak, becauseof the failure in the early warning of HAI, the lag in the emergency response,
the previous weaknesses of ADHI were exposed. As the epidemic moves into anormalized phase, the ADHI faces huge challenges in strengthening the control
of HAI, repairing shortcomings, and enhancing multisectoral collaboration.
The main aspects can be summarized as follows [1]:1. Establishment and application of fever clinics
Since their establishment during the SARS pandemic in 2003, fever clinics
have provided great convenience for the rapid diagnosis and diversion of
the majority of fever patients, serving as an extremely successful working
model for IPC [2]. The establishment of fever clinics enabled hospitals tosuddenly emerged, because the clinics served as the outposts for HAI
and became the first line of defense for IPC in healthcare facilities [3].
During the COVID-19 epidemic, fever clinics fully utilized the regional
coordination mechanism, following the principles of regional coordination
and a graded response. Hardware appliances and elastic isolation areas
team has been set up as emergency reserve personnel, which greatly reduces
the pressure on IPC [4]. In addition, fever clinics also have a primaryemergency response function. In the event of abnormal epidemic trends or
unknown infectious diseases, fever clinics should report such trends anddiseases to the ADHI and the Center for Disease Control and Prevention
as soon as possible and then initiate the response isolation procedures and1

the preparatory teams. In this way, the waste of medical resources can be
cut, the ability to respond to sudden infections can be strengthened, and theoccurrence of HAIs can be reduced.
2. Strengthening training in the use of Personal Protective
Equipment (PPE)As one of the most important guarantees of the safety of healthcare workers(HCW) during an epidemic, PPE can directly reduce the probability of
exposure for HCW and plays an important role in controlling HAIs. In theearly stages of the COVID-19 epidemic, it was quite common for HCW tocontract the infection because of the poor use of PPE [5]. In order to ensure
the safety of HCW, the ADHI has organized training in the use of PPE manytimes, and only those who pass the test on this training course can continue
assessment have led to an improvement in the use of PPE. As a result, thesafety awareness of HCW has been enhanced, and the risk of exposure has
been lowered.
3. Coordination of multisectoral cooperation
In order to achieve effective control of HAIs, the full cooperation of
the ADHI and other departments is essential. The cooperation between
different departments, such as the Logistics Department, the Disinfection
Center, and the Nursing Department, is also one of the crucial links in
IPC. Environmental disinfection conducted by cleaning staff, screeningof staff in risk areas executed by security staff, ward management, andsterile operations carried out by the Nursing Department are all importantcomponents of hospital IPC. In addition, the ADHI has formulated amanagement system for medical waste and is responsible for supervising,training, and providing the corresponding technical guidance. By working
with various departments to scientifically dispose of medical waste,
supervision. During the epidemic, the collaboration between departments
has greatly reduced the occurrence of HAIs.

The Future and Challenges of the ADHI in
the Post-Epidemic Era
With the advent of the post-epidemic era and the implementation of the Class
B infectious disease policy, which is subject to less stringent preventive andcontrol measures, the main work of the ADHI has changed from prevention tocontrol. In other words, the ADHI has moved from preventing the emergenceof contracted cases in hospitals to controlling the outbreak and the level of
HAI. This change has led to certain changes in the functions of the ADHI. In
order to better standardize and improve the infection management of medical
institutions, the role and challenges of the ADHI in the post-epidemic era are2024 vol.1

1. Management reformthe concept of horizontal diffusion and vertical syncing. In other words, the
ADHI’s role is to build hospital-based early warning centers for infectious
diseases and to sync the infection control technology with the hierarchicaldiagnosis and treatment model. First, an early warning treatment, IPC
system will be built, based in hospitals, and a responsive network platform
will be established. Urban (regional) early warning centers for infectious
diseases will be set up to strengthen contact between medical institutions
at all levels and disease prevention and control centers. This, in turn, will
facilitate the real-time release of infection information and will help tomonitor infection dynamics. Second, IPC technology will be decentralized
to grassroots medical organizations by using the hospital as IPC hub anduniting it with the community grid management model. In this way, coprevention and co-management at different levels can be achieved, and IPC
model can be synchronized with the hierarchical diagnosis and treatment
model.

The arrival of the post-epidemic era and the adjustment of epidemic prevention
policies do not mean that we can be less vigilant. Instead, we need to continue
to move forward and adjust the focus of HAI management. The future directionof the work of the ADHI can be summarized as follows. First, the groundwork
departmental rules. Second, greater importance will be placed on the spreadof acute respiratory infectious diseases, such as COVID-19, in hospitals.
Third, active measures will be implemented to prevent the occurrence of HAIamong patients, including endogenous infections and exogenous infections.
Finally, the protection of HCW against infections will be strengthened.
Protective measures should be implemented to avoid not only the occurrence
and development of respiratory infectious diseases in hospitals but also familytransmission and social transmission.
The job of preventing and controlling HAI is complicated and difficult tomanage, and it is still necessary for IPC staff to continue to learn from andpersevere with this challenge.

2. Habit reform
First, the fundamental elements of IPC will be consolidated. With thenormalized management of COVID-19, clinical-related departments,
especially the Intensive Care Unit, Blood Purification Department,
Endoscopy Department, and other key departments, should focus on
strengthening daily infection control training and promoting management

good implementation by HCW. Whether it is pre-prescription, in-process
disposal, or post-event prevention and control, IPC always run throughout
the whole process. Multidepartmental cooperation is required. Therefore, itis essential to establish IPC culture that prioritizes the concepts of “Patient
Safety First” and “Zero Cases of HAI.”
3. Conceptual reform
First, hospitals should pay more attention to HAI and change the conceptof prioritizing medical care over HAI. At the beginning of the epidemic,
because of poor infection management and delayed responses, a large
number of people contracted COVID-19, exposing the problems of weakmultidisciplinary IPC team will be organized. The nursing sector, as themain subject of HAI management in the past, has gradually been unable tomeet the growing demand for IPC. Today’s IPC departments should contain
diversified scientific teams that include specialists in clinical medicine,
microbiology, statistics, lemology, and public health to adapt to the evolving
discipline construction in HAI management.
4. Technological reformIn the post-epidemic era, HAI technology will no longer rely only on passive
monitoring by the ADHI. With the popularization of informatization and theadvent of the era of the Internet of Things, the real-time monitoring system
of HAI will play a greater role. In addition to conventional environmental
health monitoring and multidrug-resistant bacteria monitoring, a patient’s
medical instructions, tests, medical records, image reports, and otherclinical diagnostic and treatment data will be analyzed from multiple angles.
This will allow the IPC staff to have a more comprehensive and detailed
understanding of IPC situation across the whole hospital, thus providing
real-time data support for the accurate prediction of trends in the incidenceof the relevant infectious diseases and reducing the level of HAI, as wellas providing a decision-making basis for hospitals to formulate relevant
policies.

Picture of ADHI team

References

1. Wu Wenjuan, He Lihua, Liu Bo, Wang Li, Lei Han, et al. “Discussion of Nosocomial
Infection Management in Cabin Hospitals during the New Coronary Pneumonia
Epidemic”, Chinese Journal of Hospital Administration : 320-323.
2. Beijing Municipal Bureau of Health Fever Clinic Group (2003) “Study on the
Current Situation and Rational Setting Model of Fever Outpatient Clinics in Beijing
during the Post-SARS Period”, Chinese Journal of Epidemiology 24 : 999-1004.
3. Xu Shiqi, Kang Jing, Qin Xianjing, Jiang Nan, Feng Qiming, et al. (2023) “A Studyof China’s Fever Clinic Policy Texts from the Perspective of Policy Instruments,
2003-2022, Chinese Hospitals 27 : 45-49”.
4. Wu Baoling, Chen Xiaohui, Lin Peiyi, Jiang Huilin, Gong Hanxiang, et al. (2020)
Assumption of Constructive Mechanism”, Chinese Critical Care Medicine : 264-268.
5. Huang Xiaohong, Zhou Yueshan, Wu Xiaoheng, Yu Sanming, Chen Ronglin, etal. (2021) “Survey on the Improvement Needs of Medical Protective Clothing in
the Background of the Normalized Prevention and Control of Covid 19”, Chinese
Journal of Public Health Management 37 : 461-463, 468.
6. Shanghai Expert Consensus Writing Group on Nosocomial Infection Managementin the Post-Epidemic Era (2021) “Shanghai Expert Consensus on Hospital Infection
Administration in the Post-Epidemic Era (First Edition, 2021)”, Chinese Journal of
Infectious Diseases 39 : 647-655.

2

Case Study

Promoting Hand Hygiene with Unique Ideas

2024 vol. 1

What type of hand hygiene
education/training activities
are you engaged in?

After The Introduction of Alsoft A

Interviewees

From left,
Ms. Puan Zurina Mohamad Saleh
Dr. Nur Ayuni Ahamad Faudzi
Dr. Maliha Farah Nurhazirah
Ms. Siti Rokiah Yusof
Ms. Puteri Fairuz Izyan Zainuddin
Ms. Siti Amirah Ramli

Facility Information

What did you feel after using Alsoft A?
I like that it is not sticky after use. It dries quickly and makes it
easy to move on to the next procedure. Although it does not
feel sticky, it is moisturizing. Particularly during the pandemic,
alcohol-based hand rubs from various manufacturers became
available, but they sometimes caused roughness and crackingof skin on the hands. In this regard, Alsoft A was highly
effective in moisturizing, and even after frequent use, skincracks did not occur, and the product could be used with peaceof mind. We often hear from students and residents that Alsoft
A is well tolerated, and they like the texture of it.
Where do you place Alsoft A?
We have placed Alsoft A in every area considered necessary,such as clinical wards, the outpatient area, and the pharmacy
counter to provide patients and healthcare workers withimmediate access to hand disinfectants.

Facility Name: Hospital Canselor Tuanku Muhriz UKM (HCTM)
Address: Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala
Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
Number of beds: 1,300
Total number of staff: 4,000
Located in Kuala Lumpur, Malaysia, Hospital Canselor
Tuanku Muhriz UKM (HCTM), provides high-quality medical
services to the community and residents in training. The
hospital’s predecessor was the Faculty of Medicine UKM,
established in 1973, which produced specialists in various
fields of medicine and health. HCTM provides comprehensive
and integrated training through advanced facilities to bothundergraduate and postgraduate students from the Faculty of
Medicine, Faculty of Allied Health Sciences, and Faculty of
Dentistry under the motto “Integrating Learning and Research
for the Betterment of Society.”

Alsoft A on each cashier counter

Product in use
Alcohol-based hand rub (ABHR)
Alsoft Liquid Hand Disinfectant A(Alsoft A)

Steps Taken To Introduce Alsoft A
When did you hear about Alsoft A for the first time?
I first heard about Alsoft A over 15 years ago. I had heard fromother alcohol disinfectant manufacturers that its formulation is
excellent, and I was always very curious about it. Then, finally,in 2018, with the recommendation of the Ministry of Health, it
was adopted by the hospital. This was just the year before theglobal pandemic of COVID-19 began.

3

Alsoft A on the information counter

Alsoft A on the table for fillingout medical questionnaires

Do you have any training
for patients?
Yes, we have a hand hygienebooth set up in the hospitaland occasionally hold handhygiene events for patientsand their families. Children’s
events are especially popular,
and we sing hand hygiene
songs together, give quizzes,
and prepare prizes. We hopethat it is a good chance to learn
about hand hygiene in a funway.

We train about 4,000 people inhand hygiene, ranging fromstaff members, residents working
in the hospital, and students. We
teach them how to wash theirhands, how to hand rub, andwhen to perform hand hygiene.
The techniques themselves are
simple and easy to follow, but it
is difficult to get everyone to
make it a habit. We conduct
regular assessments and repeat
the instructions.

Are there any activities that are particularly effective
for young staff members and students?
We had a TikTok competition for the World Hygiene Day
campaign. Each department had to create a TikTok video
promoting hand hygiene. The department with the mostinteresting video was the winner. The young staff members andstudents took the lead in creating the videos and made thecompetition a lot of fun. It was a great opportunity to learn theimportance of hand hygiene.

Next Step
What is your next step?
The goal is to maintain a high hand hygiene compliance rate
among students and staff members at all times. Because of
these efforts, hand hygiene compliance rates have increased
over the past two years. We will continue to promote the Hand
Hygiene Relay to ensure that hand hygiene becomes a routine
medical practice for all of us.

Participation in the 7th International Conference on Prevention and Infection
Control (ICPIC)SARAYA participated as a Gold Sponsor in the International Conference on Prevention and
Infection Control (ICPIC) held in Geneva, Switzerland, from September 12 to 15, 2023. At theconference, a symposium titled “Hand hygiene: lessons learned from Asia-Pacific and Africa”
was also held under the sponsorship of SARAYA, and it was attended by many healthcare
workers from around the world.
At the symposium, Professor Hiroshige Mikamo of Aichi Medical University in Japan; Professor
Hiroyuki Kunishima and Dr. Hiroki Saito of St. Marianna University of Medicine in Japan; Dr.
Yew Fong Lee of Sarawak General Hospital, Malaysia; and Dr. Phung Manh Thang of Cho Ray
Hospital, Vietnam presented their research results on infection control efforts and the issues
being faced in healthcare facilities around the world. After the presentations, many questions
were raised, and the event was highly lively.
On December 5, 2023, an opera performance sponsored by SARAYA was held at the New York
Academy of Medicine in New York, USA, and the performance was shown on YouTube. The
SEMMELWEIS
opera, by the Brooklyn-based American Opera Project, depicts the life of the father of handhygiene, Dr. Ignaz Semmelweis (1818–1865), with spectacular music.
An obstetrician, Dr. Ignaz Semmelweis advocated “hand hygiene” as a method of preventing
infectious diseases at a time when such microorganisms as bacteria and viruses were notrecognized as contributing such diseases. However, he died without acceptance from the medical
community of the time, long after which the validity of his theory was proven. Today, handhygiene is a basic infection control measure, largely thanks to
Dr. Semmelweis.
The full opera can be viewed on YouTube:
Dr. Elaine Larson of the New York Academy of Medicine
https://youtu.be/JU_DhOSzmzo?si=x6BUEizXUrgWC-xs
further introduced the importance of public health and the impact
of Dr. Semmelweis’s work on the world, and many healthcare
workers and academics were deeply moved by the performance.

4

SARAYA Healthcare News

Risk factors for postprandial hyperglycemia and the use of low-GI foods

2024 vol.1

Dr. Yuji Murata, SARAYA Co., Ltd.

When these metabolic dominoes topple over, they can cause
life-threatening diseases, such as angina pectoris, myocardial
infarction, and stroke. Therefore, it is important for individuals to
mitigate or prevent the development of lifestyle-related diseases intheir early stages. Diabetes, dyslipidemia, hypertension, and otherlifestyle-related diseases are known as “silent killers” because they
progress with few or no subjective symptoms. In other words, theincrease in cardiovascular disorders is not due solely to hypertension
and lipid abnormalities; it can also be attributed to the lack ofawareness of postprandial glycemic control.

Postprandial hyperglycemia causes a decrease in the amount andhampers the function of insulin secretion (insulin resistance),
resulting in the inability of body tissues to adequately process
glucose, which leads to impaired glucose tolerance. This state of
impaired glucose tolerance tends to promote atherosclerosis.
Furthermore, as arteriosclerosis progresses, the risk of macrovascularcomplications such as stroke increases, ultimately resulting in death.
For this reason, it is important to manage not only fasting blood
glucose levels but also postprandial blood glucose. It has also beenreported that abnormal postprandial blood glucose levels worsen
when HbA1c exceeds 6.5%. Therefore, improving postprandial
hyperglycemia in its early stages and maintaining an appropriate
HbA1c levels will reduce the onset and progression of diabetes andelevated fasting blood glucose levels.

In particular, prediabetics and those who require specific healthguidance due to higher blood glucose levels than normal often havefasting blood glucose levels below 110 mg/dL—the normal range inJapan. If only fasting blood glucose levels are measured, postprandial
hyperglycemia may be overlooked. Even if a patient should undergo
a thorough physical examination, the postprandial blood glucose test

In the past, fasting blood glucose levels were used mainly to control
health. In recent years, it has been found that a rapid postprandial risein blood glucose levels contributes to impaired blood flow andvascular damage, which is deeply related to arteriosclerosis and othervascular lesions. (2)(3) The relationship between postprandial
hyperglycemia and vascular lesions can be compared to a roadwith a high volume of traffic that may be severely damaged and inneed of repair. The greater the amount of sugar, carbohydrates,
and lipids flowing through the blood vessels, the more likely thevascular cells are to become damaged.

glucose and lipids are present after a meal, these endothelial cells aredamaged, the protective action of blood vessels is reduced, and theintima thickens and hardens, leading to arteriosclerosis. The
development of arteriosclerosis further leads to the clogging(infarction) of blood vessels, thus resulting in cerebral infarction,
myocardial infarction, and other life-threatening conditions.

Blood vessels are composed of three layers: intima, media, andadventitia. The intima is in contact with the blood circulation in theintravascular lumen and is composed of endothelial cells—a thinlayer of cells that make up the inner surface of the vessel. It has beenfound that vascular endothelial cells constantly produce nitric oxide(NO) and exhibit vascular sclerosis inhibitory effects, vasodilatory
effects, and anti-arteriosclerotic effects, thus preventing the vascularwall from developing atherosclerosis. However, when high blood

In response to this, SARAYA provided the world with LAKANTO®,
a zero-calorie sugar-substitute sweetener made by adding monk
fruit extract to erythritol. (4), LAKANTO® is a vegetative sweetenerthat undergoes thorough quality control and does not affect blood
sugar levels or insulin.

Sucrose Jelly

Sucrose Jelly

Lakanto Jelly

300
250

20

200

16

150
100
50
0

Lakanto Jelly

24

IRI( µ IU/mL)(oral glucose tolerance test, OGTT) is generally not performed,
which can lead to the development and progression of unnoticed
diabetes.

Glucose(mg/dL)

While Japan has the world’s longest life expectancy, its incidence of
cardiac and vascular diseases triggered by lifestyle-related diseases isincreasing. This effect, “metabolic dominoes,” (Figure 1) has been
introduced in many publications. If one continues to have inappropriate
lifestyle habits, the dominoes of obesity, hyperglycemia, hypertension,
lipid disorders, etc. will fall and eventually lead to metabolic
syndrome. (1)

12
8
4

0

30

60

90

120

0

0

30

60

90

time (min)time (min)(a) Post-load blood glucose load(b) Insulin level120

Blood sugar level and insulin level after loading test diet ( )/ control diet ( ) on 12 examinees
Modified from Yuji Murata et al. The journal of Metabolism and Clinical Nutrition 12(1): 41-44, 2009

Figure 2. Effects of LAKANTO® on blood glucose and insulin in diabetics
Figure 2 shows the effects of LAKANTO® on blood glucose andinsulin in diabetics. Prototype jellies containing 25 g of LAKANTO®
(test meal) and jellies containing 25 g of sucrose (control meal) wereconsumed by 12 diabetic patients, and blood glucose levels were
measured at 30-minute intervals up to 120 minutes after
consumption. The results of these clinical studies confirmed that
LAKANTO® had absolutely no effect on blood glucose and insulinlevels.
Modified from Hiroshi Ito. Japanese journal of clinical medicine. 2003;61(10), 1837-1843

Figure 1. Concept of Metabolic Domino Effect in metabolic syndrome

5index (GI) food that suppresses the rapid rise in blood glucose after
meals. “Healthy Rice,” which can be eaten as a staple food, consists
mainly of special barley, which is rich in dietary fiber and does
not easily raise blood sugar, combined with high-amylose rice. This
product is the world’s first rice designed to prevent a rapid rise inblood glucose levels after consumption (patent registered No.
5614982).

As derivative products of LAKANTO®, SARAYA launched seasonings
including “LAKANTO® Sukiyaki Sauce” and “LAKANTO® Low
Carb All-purpose Vinegar” as well as “Healthy Rice,” a low Glycemic

6

2024 vol.1

30.0
252

210

215

200

190

130
110

140

Commercial Rice
Healthy Rice

0h

127

30 min60 min

100
80
60

5.0
0.0

120 min

79

96

70

55
Commercial Rice
Healthy Rice

30min

60min

20.0

10.0
5.0

120min

15000

9000

0

4.2
0h

30 min11.9

60 min

120 minCommercial Rice
Healthy Rice

17.7
17.4

0

8.9
7.7

９.9

30min

7.2

60min

120minComparison in insulin value4225.5

2000

10852.5

Commercial Rice
Healthy Rice

7587
3381

500

1177.5 1050
AUC30

AUC60

Commercial Rice
Healthy Rice

1500

AUC120

0

529
134

116

Point 3

Plant-derived andcalorie-freeSame sweetness as
sugar, easy to use

Sweetness remains
even when heated

A plant-derived sweetenermade from a highly purified
extract of monk fruit, used in
herbal medicine, and erythritol,a sweetener derived from corn
fermentation.

No need for weight conversions,
as its ingredients are perfectly
balanced for a blend that has asweetening quality close to thatof sugar.

Resistant to heat, it does not
lose its sweetness whencooked.

AUC30

381

AUC60

LAKANTO S

AUC120Comparison in insulin area (AUC)

Figure 3. Glycemic responses of“Healthy Rice” compared tocommercial rice

Figure 4. Insulin responses of“Healthy Rice” compared tocommercial rice

Modified from Aya Maeda et al. JOURNAL OF JAPANESE SOCIETY OF
CLINICAL NUTRITION. 2012; 34(2).2-7.

Modified from Aya Maeda et al. JOURNAL OF JAPANESE SOCIETY OF
CLINICAL NUTRITION. 2012; 34(2).2-7.

Figure 3 shows the blood glucose levels of 10 Type 2 diabetic
subjects (six males and four females) 120 minutes after consuming
cooked “Healthy Rice” (test meal) and commercial rice (controlmeal). The blood glucose levels of individuals who had justconsumed “Healthy Rice” (test meal) were statistically significantly
lower than those who had just had commercial rice (control meal) in

glucose or insulin secretion after ingestion (low-GI foods). We hopethat these products will help prevent the progression oflifestyle-related diseases and encourage individuals to takepostprandial blood glucose management into consideration
andprevent the dominoes of lifestyle-related diseases from topplingover.

Thus, we find that the food products provided by SARAYA are
designed with formulations that do not cause a rapid rise in blood

Point 2

896

Comparison in blood glucose area (AUC)

and insulin area (AUC), confirming that there are statisticallysignificant differences between the two types of rice. (6)Point 1

1582

1000

glucose area (area under the curve, AUC). Figure 4 compares insulin
concentrations after consumption of commercial rice (control meal),
as in Figure 3. Insulin concentrations after consumption of “Healthy
Rice” (test meal) were lower than those of commercial rice (control

7

14.5

Commercial Rice
Healthy Rice

2500

6000
3000

12.3

15.0

Comparison in blood glucose value

12000

4.6

25.0

85

20

13.2

Insulin response of
Healthy Rice and commercial rice

125

40
0

15.0
10.0

21.9

21.7

20.0

Glycemic response of
Healthy Rice and commercial rice120
BS (mg/dl)

185

170
130

25.0

223

206

IRI (μIU/ml)

BS (mg/dL)

230

IRI (μIU/mL)

250

150

LAKANTO S
NATURAL SWEETENER

Sugar*It has the same mass and the same sweetness as sugar.
Approximate bulk: 1 tablespoon = 13g, 1 teaspoon = 4g

What is Monk Fruit?
It is a member of the Cucurbitaceae family that originated in Guilin, China, and is said to be the "divine fruit oflongevity" since ancient times. It is now designated as a protected plant, and is so valuable that it is forbidden
to take fresh fruit out of the country.
Saraya has established the technology to produce high-purity monk fruits extract, which is about 300 times
sweeter than sugar, using a proprietary process. At our factory in Guilin, we extract only the sweet component
from fresh monk fruits under strict control by contract farmers, and manufacture lakanto in our factories inJapan and the United States.

References:
1. Ito Hiroshi, メタボリックドミノとは 生活習慣病の新しいとらえ方
Metabolic Domino - A New Way to View Lifestyle-related Diseases. Japanese Journal of Clinical
Medicine. 2003; 61(10): 1837–1843
2. David J.A. Jenkins et al. Glycemic index of foods: a physiological basis for carbohydrate exchange.
The American Journal of Clinical Nutrition. 1981; 34: 362–366
3. Christian K. Roberts et al. Effects of Glycemic Load on Metabolic Health and Type 2 Diabetes
Mellitus. Journal of Diabetes Science and Technology. 2009 Jul; 3(4): 697–704.
4. Yuji Murata et al. 羅漢果配糖体の甘味特性およびその改善of monk fruits glycosides and their improvement. Food Science and Technology Research. The
Japanese Society for Food Science and Technology. 2006; 53(10), 527–533
5. Keiko Kondo et al. 糖尿病患者における甘味料「ラカントS」の血糖値、インスリン値に及ぼす影響
diabetic patients. The Journal of Metabolism and Clinical Nutrition. 2009; 12(1): 41–49
6. Aya Maeda et al. 高アミロース米配合の低GI米による血糖抑制とその意義
Glycemic control by low GI rice blended with high amylose rice and its significance. Journal ofJapanese Society of Clinical Nutrition. 2012; 34(2): 2–7.

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NATURAL SWEETENERLAKANTO S
Lakanto S Granule

Lakanto S Liquid

Calorie-free, sugar-free,plant-derived sweetener frommonk fruit. It has the same
sweetness as sugar and isresistant to heat, making itsuitable for a variety of uses.

Lakanto S in syrup type that
dissolves quickly. Suitable forsweetening drinks and cold
dishes.

SEASONING
Lakanto Low Carb
All-purpose Vinegar

Lakanto Sukiyaki
Sauce

Seasoning vinegar using Lakanto.
Pour over salads, fry foods, andmake pickled foods.

Sukiyaki-flavored sauce madewith lakanto. For simmered dishes
and slow cooking.
For those who want to eat delicious, low-sugar rice “Healthy Rice" is a series of low-calorie
and low-sugar rice products designed for people who are trying to avoid eating white rice.
“Healthy Rice” was developed focusing on the taste and texture of rice. Just by replacing
white rice, you can enjoy a healthy and easy meal.

CANDY
Milk Coffee Flavor
Strawberries andCream Flavor

Matcha Green Tea
and Milk Flavor

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Lakanto Zero
Calorie Hard
Candy
A long-selling productfor 15 years, born from
customer requests.
Made with erythritol,
less likely to cause
cavities.

Material & Taste
A plant-derived sweetener made from ahighly purified extract of monk fruit, used in
herbal medicine, and erythritol, a sweetener
derived from corn fermentation.

TextureThe barley is polished to make the texture easy
to eat, matching the shape and size of the whiterice. The use of rice and barley makes it moresatisfying and provides the fullness that only
rice can provide.

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