The Fourth Bizan Immunology Symposium at University of Tokushima (BISUT4)“Immune System Development, Deviation, and Regulation”
Date:Thursday 29 January and Friday 30 January 2015
Venue:
Fujii Memorial Hall, Kuramoto Campus, University of Tokushima
Guest speakers:
Hisashi Arase (Osaka)
Isaac Chiu (Boston)
Sidonia Fagarasan (Yokohama)
Yoshinori Fukui (Fukuoka)
Kenya Honda (Tokyo)
Yoichiro Iwakura (Tokyo)
Gabriel Núñez (Michigan)
Takashi Saito (Yokohama)
Jonathan Sprent (Sydney)
Host organizers:
Naozumi Ishimaru (Graduate School of Oral Sciences)
Taku Okazaki (Institute for Genome Research)
Mitsuru Matsumoto (Institute for Enzyme Research)
Yoshiyuki Minegishi (Institute for Genome Research)
Tohru Sakai (Graduate School of Nutrition and Bioscience)
Yousuke Takahama (Institute for Genome Research)
Tetsuo Yamazaki (Graduate School of Pharmaceutical Sciences)
Koji Yasutomo (Graduate School of Medical Sciences)
Contact:
Immunology Program at the University of Tokushima [iPUT]
3-18-15 Kuramoto, Tokushima 770-8503, Japan
Phone: +81-88-633-9452
E-mail: takahama@genome.tokushima-u.ac.jp
Sponsored by:Strategic Project for Innovative Research “iPUT”, University of Tokushima
Co-sponsored by:
MEXT Scientific Research on Analysis and Synthesis of Multidimentional Immune Organ Network
Joint Usage Research Center, Institute for Enzyme Research, University of Tokushima

Thursday 29 January
13:00-13:10

Opening remarks by Yousuke Takahama

Session 1. TCR-MHC and immune system
Chaired by Tetsuo Yamazaki
13:10-13:40

Jonathan Sprent (Sydney)
TCR tuning and self tolerance

13:40-14:10

Takashi Saito (Yokohama)Spacial regulation of T cell activation at Immune synapse

14:10-14:30

Yousuke Takahama (Tokushima)
Positive selection conditions TCR responsiveness in T cells

14:30-15:00

Hisashi Arase (Osaka)
Cellular misfolded proteins complexed with MHC class II molecules aretargets for autoimmune diseases

Short talks 1
Chaired by Il-mi Okazaki
15:00-15:10

Kyoko Masuda (Kyoto)
Segregation of γδ T cell progenitors prior to TCRβ chain generearrangement independently of TCR-mediated signals

15:10-15:20

Izumi Ohigashi (Tokushima)
Adult thymus medullary epithelium is maintained and regenerated bylineage restricted cells rather than bipotent progenitors

15:20-15:30

Erdenezaya Odkhuu (Aichi)
The search for endogenous ligand of RP105/MD1 receptor complex onB cells

Group photo & coffeeSession 2. Autoimmune mechanisms
Chaired by Mitsuru Matsumoto
16:00-16:30

Yoshinori Fukui (Fukuoka)
A novel mechanism controlling Aire protein expression in the thymus

16:30-16:50

Mitsuru Matsumoto (Tokushima)Transgenic Aire expression at the ectopic sites to elucidate the uniquefunction of Aire

16:50-17:20

Yoichiro Iwakura (Tokyo)
Pathogenic mechanisms of rheumatoid arthritis revealed by animal models

17:20-17:40

Koji Yasutomo (Tokushima)
Genetic dissection of autoinflammatory disorders

Short talks 2

Chaired by Tohru Sakai

17:40-17:50

Aoi Akitsu (Tokyo)
IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due toan intrinsic defect in IL-17-producing gamma delta T cells

17:50-18:00

Yumiko Nishikawa (Tokushima)
Dysregulation of IgE homeostasis in hyper-IgE syndrome

18:00-18:10

Lynett Danks (Tokyo)
RANKL expressed on synovial fibroblasts is primarily responsible for boneerosions during joint inflammation

18:10-18:20

Il-mi Okazaki (Tokushima)
Genetic reconstitution of autoimmune diseases in mice.

Dinner at Isuien (19:00-21:00)
Hosted by Sumihare Noji, Vice President, University of Tokushima
MC by Naozumi Ishimaru

Friday 30 January
Session 3. Inflammation and regulation
Chaired by Koji Yasutomo
09:00-09:30

Gabriel Núñez (Michigan)
Sensing pathogenic and commensal bacteria via the inflammasomes inthe gut

09:30-10:00

Sidonia Fagarasan (Yokohama)
Regulation of gut microbiota by Foxp3+ T cells and IgA

10:00-10:20

Yoshiyuki Minegishi (Tokushima)
Molecular mechanisms and therapeutic approaches to hyper-IgE syndrome

CoffeeSession 4. Immune defense
Chaired by Taku Okazaki
10:40-11:10

Isaac Chiu (Boston)
The role of nociceptive sensory neurons in neuro-immune modulationand host defense

11:10-11:40

Kenya Honda (Tokyo)
Regulation of T cells by the gut microbiota

11:40-12:00

Taku Okazaki (Tokushima)
Regulation of autoimmunity by immuno-inhibitory receptors

12:00-12:20

Tetsuo Yamazaki (Tokushima)
Manipulation of the ER: a novel strategy against protein deposition disease

Short talks 3
Chaired by Yoshiyuki Minegishi
12:20-12:30

Takashi Kanaya (Yokohama)IL-22BP affects the properties of the follicle-associated epithelium of Peyer’s
patches through inhibiting IL-22 signaling

12:30-12:40

Takahiro Furukawa (Tokushima)
Delta1 regulates CD4T cell survival

12:40-12:50

Hiroshi Kawano (Tokushima)
Aire expression in medullary thymic epithelial cells is conditional

12:50-13:00

Tomoyuki Kondo (Tokushima)
Crosstalk between tumor immunity and autoimmunity

13:00-13:10

Tohru Sakai (Tokushima)
Soy isoflavone regulates immune responses

Lunch with students (13:30-14:30)
Organized by Yasusei Kudo & Kensuke Takada