Long life implant
Long life implant is an expression to enhance the life of AQB implant.
One month implant is an easy expression to enhance the clinical time of AQB implant.
Question 1
I know that they are many kinds of implants but is there any difference among them?
Answer 1
There are many implant manufactures in the world and they manufacture and sell
original implants.
Therefore there are many implants as implant manufactures.
However, we can distinguish implants largely by long life implants which ahs bio
affinity power and others.
Other implants include HA implant (HA coating implant) which was explained earlier
and titanium implants.
They are the bioactive but do not have bio affinity power, therefore they cannot be longlife implants which are taken into the body to integrate.
Question 2
If so, why is this great revolutionary implant that patients want to have the most is not
spreading around the world?
I believe that this long life implant should become popular like iPad in this world andpeople should accept it positively.
Answer 2
That is a great question.
In fact, long life implant is a medical device, therefore we cannot freely advertise andprovide information to customers by disclosing information like iPad can.
Basically, dentists choose their implants first.
Next, patients use the implant that their dentist recommends.
For this reason, implants are selected and spread by the decision of dentists but not by
the patients.
Question 3
So, if we can meet this long life implant, it means that we are lucky.
But don‟t you think that this great implant should be widely used?

I think that would be an act of kindness and contribution to society.
Don‟t you think that you should help patients from unnecessary time and risks?
Answer 3
That is a normal and right idea.
First, you are lucky because you have met this long life implant.
Second, long life implant would help people on earth if you and people who have goodexperience of this implant conduct word of mouth communication of your and theirexperiences.
Question 4
So, what kind of people actually has long life implant?
Could you please tell me the experience and desire of patients?
Answer 4(1) That would be people who want to have food texture and tooth that works as same asone`s own lost tooth. Long life implant can realize such dreams.
Ms. Reiko Yoshibayashi who has long life implants wanted to eat food freely, enjoy
meals, and sing with her mouth wide open as she could with her own teeth.
People who wants to improve concentration by gritting one`s teeth.
Long life implant realized these wishes.
Experience of AQB Part 4“I am enjoying my life, eating and singing”
Ms. Reiko Yoshibayashi, 62 year-old, woman
Since I was 9 years old or 10 years old, I had started to go to dental clinic to treat teeth.
When I had lost my baby teeth and got permanent ones, I remember that everything
seemed fine. However, dental caries started to appear later on.
I think that this happened due to the poor teeth brushing. For that reason, when small
dental carries appeared, I think that my dentist cut an affected tooth a little and filled itwith amalgam.
Several years later the dental carries started to hurt again, so this time my dentist cut
the tooth more and injected a medicine that kills nerve. A couple of days later, thenerves were extracted.

I remember that I received couple treatments to clean inside of affected tooth.
When inside of the tooth became clean, my dentist had taken the tooth model and filled
it with substance like a metal.
Even when the root was fine, white part went bad so I had to have new post crowns
when former ones went bad.
I had to replace a post crown several times for the same tooth.
Yet, even the new ones` root is cracked and broken, therefore my tooth needed to be
extracted.
“Oh dear, my natural teeth have almost gone!!”, I was really sad.
In the mean time, my life had passed so quickly that I was in 50s.
The condition of my mouth was, I had total three partial dentures at upper and lower
side of mouth.
Especially, upper side`s left and right molars and front teeth were denture,consequently dentures covered my upper jaw. For that reason when I tried to swallow
food or drink, sometimes the denture suddenly went into the deep part of throat,
consequently I chocked many times.
I had come to think that this would be the most dangerous thing when I grow older.
I had worked as a nurse before and I saw many people who were hospitalized due to thepoor health and illness. When they lay down on a bed, the danger increased more thatsometimes they swallowed food to the lung accidentally and had aspiration pneumonitis
which led to the terrible results. Because of that and I had worn my denture, suchanxiety crossed my mind.
After meals, I had to take my denture out, wash it, and before I go to bed I had to put it
in a special container with disinfected solution.
But when denture was out, I assume that I still pressured teeth without consciousness
while I was sleeping, so teeth gradually moved and my row of teeth became bad.
So, yes I had to replace my dentures many times.
In the mean while, I had started to see the sign of „Implant‟, but I was not interested. I
just happened to know the dental clinic that had the one month implant through myfriend.
Feeling of uneasiness crossed my mind.

“Is it really ok to install a foreign matter into the bone?”“Would I get hurt?”“Would I be able to bite as my natural tooth?”“Implant must be expensive”
I was worried about a lot of things.
I made an appointment and I let my dentist to check the gum at tooth extraction siteand he decided the place to install initial implants.
First two implants were planned to install at right lower side. After the anesthesia, theoperation had started. I was nervous but the surgery proceeded quickly.
The surgery was able to finish in about 30 minutes. I gargled couple of times but I did
not find any bleeding after that. My dentist told me that I need to take pain killer
because anesthesia would wear off in 30 minutes. But I only took one pain killer
because I did not feel any pain, consequently I did not take any more of them.
Three months later from the first surgery, I had an implant surgery for two opposing
teeth sites of preinstalled two implants. I was able to relax during the second surgery.
I only took a pain killer once, 30 minutes after the surgery.
Both former implants and latter implants took one month for me to be able to stat tobite food.
I first thought “Is this really ok?” but surprisingly, I was able to bite meat andvegetables without hesitation as I wanted.
I was able to bite even thick Japanese radish, I actually wanted to eat this all the timehence I was impressed.
Of course, I was able to eat thick Japanese rice cracker.
When I think of the unpleasantness of post crowns and dentures, I was in hell and my
new implant made me to be in heaven.
Biting force is significantly different.
My implants are really strong that I can even think I am able to bite food stronger withthem than my natural teeth.
All of my implant surgery has finished after installing an implant at upper left side. I
am able to bite well now so, I feel like “Good bye, denture!”
Also during conversation, I was not able to pronounce nicely because I had a dentureand air leaked from the clearance. Therefore sometimes, my friends said “Sorry?” to ask
me to repeat what I said.
I love to sing and now I am able to sing with my mouth wide open, thus I feel that mylife gets better every day.
I have started to bite well so I have not had a stomachache recently.
I really think that I made a right decision to have implants.
Also, for the cost of an implant. I heard that it would cost 350,000 yen for one implant atother dental clinic, but it was only 139,000 yen and did not need to pay for any othercosts.
I can eat food and enjoy everyday life.

(2) People who wish to escape from the troublesome and unpleasantness of denture, lossof concentration, and be unable to bite and people who wish to have great meals withone`s own tooth and bite freely even solid food.
Long life implant AQB can realize such dreams.
①People who have trouble with their dentures have real troubles.
a Daily maintenance is troublesome.
b Biting with gingiva but not with jawbone, therefore food is not delicious. Eating is notfun.
c Food get caught between denture during a meal, unpleasantness, and pain.
d Needs to pay attention to others because of bad breathe Be unable to eat hard or sticky food.
② Risk would arise because of denture placement.
a For example, if denture is full denture, jawbone would be absorbed rapidly and getthinner because the denture is placed on gingiva and the jaw bone does not receive
pressure directly.
b As a result, denture needs to be replaced many times. All of such occasions cost.
c For example, in case of partial denture, it is attached with healthy tooth by springcalled clasp, but even the healthy tooth would start to wobble and eventually the tooth
may be lost.

d While putting the denture in and taking it out, denture may become unfit.
Consequently the denture has to be replaced many times.
e When bridge is put on a healthy tooth, the healthy tooth would become bad.
Experience of AQB Part 5“Released from my denture”
Ms. Yasuko Yoshikawa, 63 years old, woman
I turned 63 this year.
I only had one false tooth but 36 years later, now I have nine dentures.
I had complex about denture, therefore I was not able to talk or laugh with my mouth
wide open.
Even when I went out, I knew that I could not bite stake so I refrained from eating it
and I did not have courage to bite solid food such as an apple.
Also, when I went on a trip, I did not want anyone to see my face without my denture, so
I wore mask to sleep.
When visitor came to my house suddenly, I fell into a panic. I need to look for mydenture and a mask.
At that time, I noticed that my neighbor friend`s tooth become very pretty, thus I asked
her what she did. Then I found out that it was an implant.
It was the first time that I heard about an implant.
Having know that such a wonderful product exist in this world, I was in the seventh
heaven.
Therefore, I went to the dental clinic to see if I could have implant. The result was fine.
However, I was worried that I would feel pain because I heard that implant would beinstalled in my bone, but when the surgery started, the anxiety went away.
I started to feel confident by having implants.
I am free from denture life.
I have nine implants now.
Thanks to the implants, now I can derive pleasure from the second life, trip, and food.
I really appreciate my implants

(3) To prevent dementia, as he is aging.
With the increase in the number of teeth lost, the chewing ability deteriorates. This canlead to reduction in the number of stimuli transmitted to the brain, which canconsequently decrease the amount of neurotransmitters such as acetylcholines to be
secreted, therefore promoting the progress of Alzheimer‟s disease. The risk of dementia
in those with several missing teeth is double that of the persons with 20 or more teeth
remaining. The number of stimuli transmitted from the jaw bone to the brain in theindividuals with full artificial dentures is small, indicating that the reduction in theamount of neurotransmitters such as acetylcholine secreted, consequently leading toincreased risk of dementia.
The role of the long-life implant is effective in preventing such issues arising. With its
ability to apply enough stimuli to the brain from the mastication, it can activate thesecretion of acetylcholine etc. This is possible it allows one to chew with more strengththan with their teeth.
Experience of AQB part 6
Escaping from dementia
Mr. Hideo Moriyama, 64 year-old, man
My wife and I went on our first vacation abroad to Guam. It was a show of myappreciation to my wife for sticking till my time of retirement.
My wife was in high spirits buying her chocolate ice cream without minding her age,saying,“It was my dream to be able to eat ice cream while walking around!” and started
walking on the Guam‟s main street while eating her ice-cream.
When I turned around to say “ we are nearly at the Hotel!” I find my wife with her
T-shirt covered in chocolate, crying.
I just thought she was upset because of getting her T-shirt dirty, and so said you canclean it in the room, so got back to the hotel.
I was finding that my wife‟s state had deteriorated gradually after that incident. She
tried to go to dinner without putting her dentures in, or started buying the same things
as a present for the grandchildren. So I travelled back home getting chills with thethought that my wife had developed dementia.

Having returned home, I forced my wife who was unwilling, to go to the doctors. She
was indeed diagnosed with early stages of dementia.
I was looking forward to starting my second life as a taxi driver, and had alreadyobtained the licenses for it. However, after this incident, I couldn‟t bring myself to go towork leaving my wife alone in the house, let alone go out of the house for few hours.
My daughter worried of her condition, came to visit her if she had free time, but during
her visits, my wife appeared normal, in the end, my daughter thought I was the one who
was acting up.
My final decision as to get her to undergo implant treatment was made when she had
started to forget where she had left her dentures, and when she started eating her
favorite nure-rice cake without her dentures, and ending up bleeding from the gum.
These sightings of my wife worried me, as I did not know what else she might put in her
mouth. This worry and for her safety, I made my wife go through with the implant
treatment.
I explained this to my wife, but did not gather whether she actually understood or not,but she tolerated it well, and went through with the implant surgery following thedentist‟s instructions, inserting five in total to the upper and the lower jaws.
Three months later, my wife went to buy the rice cakes from the shrine on the festive
day that takes place 28th of every month, saying she was craving for the rice cakes.
My wife started to be able to eat solid food without any problem, and as I had heard thatthe chewing of solid food would stimulate the brain, she started to be able to havenormal conversations with me.
Recently, she became able to prepare for meals which she had not been able to do sincegetting back from our holiday to Guam.
Literally, our life has been able to return to normal. Implant treatment was such a goodidea. I am sincerely thankful from the depth of my heart.

(4) People who have the desire to laugh out loud in front of people and also those whowant AQB long life implant.
Those who have tooth loss in the locations where it is clearly visible from the front canbecome afraid of being in front of people, or cover their mouth, and cannot openly laughout loud. As a result, they eventually become timid, affecting them psychologically.
So here, the AQB long-life implant presents these people with the positive spirit.
Experience of AQB part 7
My bad breath pointed out by my grandson has improved
Ms. Haruko Aida, 61 year old, woman
My mind went blank with the comment made by my grandson a year ago. That day was
my son‟s first child, Hitoshi‟s third birthday, and I had cooked his favorite calamari,baked a special cake and went to visit him with my husband.
Hitoshi was incredibly pleased with the present, Pokemon game, given by my husband.
Getting excited with the game with my husband, calling him “Granpa Granpa!”.
I couldn‟t possibly lose as a Granma.
“Hitoshi, I baked a cake, shall we all eat?, it‟s chocolate, I know you like it”. He usuallyeats the cake straightaway, but he was ignoring me for some reason.
“Is something wrong? Its Gramma‟s cake.”
Hitoshi replied “later!” and went back to his Pokemon game.
I just ended up snapping at my husband saying “you should have given him the present
after the cake!”
The birthday dinner table was laden with feast including my calamari, and Hitoshi
seemed to be in excellent spirit munching away. Then, came the turn with the birthday
cake. I held up Hitoshi in my arms and said,“Go on and blow out the candle, Hitoshi!”It was then that he shouted out,
“Granma your breath stinks!” with a scrawl. The whole room went silent.
Hitoshi‟s mother telling Hitoshi to “apologize to your granma!” had no effect on my moodfalling to the rock bottom.
I snapped back at my husband when he said, “it‟s your denture that smells”, saying,“You should have told me that when you noticed!”
For the rest of the day, the thought circling my mind were, “I‟m always cleaning thedenture everyday!” or “the dentist reassured me that denture was enough”, trying tojustify the fact that I was taking enough care not to let it smell.

My husband came to inform me, in a state of low degree of depression, that he had founda dentist who does AQB implants.
The first question I asked the dentist was whether the bad breath would disappear.
The decision to place AQB implant was made with the insurance by the dentist who said,“the sense of AQB implant becomes one that is similar to your own teeth, so there
should be no problem as long as you continue to brush your teeth”.
A year later, on the day of Hitoshi‟s birthday…
Hitoshi let me hug him without any reluctance. And said with his mouth filled withbirthday cake,“I love Granma‟s cake!”
The comment made me cry with pleasure.
Thank you very much implant!

(5) The long life implant AQB can fulfill a wish of those who want to be beautiful.
A beautiful dentition highlights a beautiful face.
It is a chance for people who use a denture or have lost anterior teeth to be beautiful.
Question 5
What is the difference between a long life implant (AQB implant) and a bridge?
Answer 5(1) A bridge is not recommended because grinding of healthy teeth will be necessary.
The best treatment for tooth loss is using long life implant which becomes one`s own
tooth because its implant placement does not require grinding of healthy teeth.
(2) I will explain it concretely the following.
A bridge (an artificial crown) requires grinding of healthy teeth which adjacent to theextracted cavity.
Target of grinding is enamel and a part of dentin, so these teeth become unhealthy.
Next, a bridge is attached on adjacent grinded teeth, so occlusal pressure applies to thegrinded teeth including the extracted cavity.
It will be burden on the grinded teeth which support the bridge and will give damage tothem, consequently they will be fragile, as a result, extraction of them will be necessary.

(3) Moreover, the enamel is grinded and the dentin is exposed, therefore it will become
easy for intraoral pathogenic bacteria to invade from the grinded site. Subsequently
dental caries or periodontal disease tends to occur.
Also, plaque is easy to accumulate on the root of the bridge or between the bridge andteeth.
It is a big step to the periodontal disease.
For these reasons, extraction will be necessary.
(4) In addition, if the tooth which supports the bridge is decayed, it is impossible to treat
the decayed tooth unless the bridge is broken to be removed.
(5)Tooth extraction means that treatment such as denture attachment or implant
placement is necessary.
Hence, I recommend the long life implant for the treatment. I can say this because as I
explained before, denture has some problems.
(6) The problem related to a bridge that you need to understood is that the alveolar boneof the extracted cavity become thinner gradually.

Question 6
My jaw is edentulous and I have a denture, but I am always annoyed by uncomfortablefeeling. Today, I am here because I have heard a good reputation of „long life implant‟.
Please tell me difference between a denture and the long life implant in my case.
Answer 6
I see.
You already have a denture, therefore I will compare it with the long life implant andexplain the characteristic of the implant.
(1) Regarding a denture, you eat food with the denture which is just placed upon thegingiva, subsequently it is impossible to enjoy eating because the chewing strength isweak and feeling is bad. Of course, it is impossible to crunch or bite off solid food.
You will also have a trouble in biting something sticky.
By contrast, the long life implant is fixed into the jawbone therefore you will havechewing strength with the jawbone. For that reason, it becomes possible to eat and biteoff solid food freely.
As a matter of course, you can taste food.
In addition, you can grit your teeth and it will improve your concentration.
This is impossible with a denture.
(2) A denture gives you foreign body sensation, uncomfortable feeling, or pain.
On the other hand, a long life implant „becomes your own tooth‟, does not give you
uncomfortable feeling or pain.
You will forget about having an implant because the implant make you feel ascompletely same as your own teeth.
(3) The maintenance of a denture is a hard task because it can habitually be smelly andunclean.
By contrast, a long life implant requires no maintenance because it will not be smelly
and unclean.
If you brush your implant as your tooth, other maintenance will not be required.
(4)Appearance of a denture is bad, as a result, you cannot laugh or sing with your mouth
wide open.
On the other hand, the long life implant makes your mouth beautiful by realizing
natural dentition. Therefore, you can laugh and sing with your mouth wide open as you
please.
(5) Having a denture will make you to not eat and taste every food, therefore it is not
perfect in terms of health.

In contrast, you can eat anything with the long life implant, therefore it can help
maintaining your health.
(6) If you have a denture, you feel inconvenience to exercise because you are unable togrit your teeth, consequently, you will be away from exercise.
On the other hand, in regard to the long life implant, you can run or throw something
while gritting your teeth. Therefore, you can put your strength when you exercise.

Question 7
Is it true that a long life implant can improve dementia?
Answer 7
That‟s true.
There are two types of dementia; the cerebrovascular dementia and the dementia of
Alzheimer type. In regard to these two types of dementia, in case when its cause seems
to be periodontal disease and the disease is unlikely to be cured, I believe that using an
implant would be very helpful to deal with the dementia.
The following is an explanations and reasons for my opinion.
(1) Firstly, I will explain the cerebrovascular dementia. Its cause is a cerebral apoplexy.
The cerebral apoplexy is caused by arteriosclerosis which occurs in cerebral bloodvessels, hence it is important to prevent the arteriosclerosis. Recently, new findings has
started to attract the attention that pathogenic bacteria in mouth and periodontal
pathogenic is the cause of arteriosclerosis. It implies the importance to cure theperiodontal disease in order to cure the arteriosclerosis.
(2) According to the study from the Ministry of Health, Labour and Welfare, comparedpeople who have more than 20 of their teeth, with others, people who have few teeth
and using a denture has 1.2 times more risk, and those who have few teeth but do not
use a denture has 1.9 times more risk to have dementia.
Also, the person who cannot chew solid food has 1.5 times more risk to have dementia
than people who can chew it.
It is thought that elderly with few teeth is at higher risk of having dementia when the
periodontal disease is related to cerebral infraction which can be the one of causes of thedementia or decline of chewing strength that loses the stimuli to the brain.
●Risk of dementia of elderly people who have no tooth(3) Therefore, it is possible to recover stimulus for the brain by obtaining chewing
strength with an implant, consequently there will be an opportunity to improve thedementia.
(4) Early extraction of affected tooth and implant placement is thought to be an efficientapproach for a patient who has advanced periodontal disease which is unlikely to be
cured.
This is a great method to eliminate the cause of lifestyle related diseases which occurs
by the periodontal disease and to recover chewing strongly largely.
(5) Chewing with teeth is also deeply related to dementia of Alzheimer type.
The dementia of Alzheimer type is a disease which has a characteristic to show brain
atrophy. A decrease of acetylcholine secretion is thought to be the cause of the dementia
of Alzheimer type.
It is known that a stimulus is transmitted from the periodontal membrane to the brain
and acetylcholine secretion increases by chewing. From analysis of CT scan, it hasreported that the fewer the remaining teeth, the further the progress of brain atrophy.
Prevention of periodontal disease and teeth preservation will affect the prevention of
the dementia of Alzheimer type.
(6) It is known that the patient with Alzheimer's brain show characteristic pathologic
and biochemical lesion.
In addition to the remarkable brain atrophy caused by the loss of nerve cells, theAlzheimer‟s shows following characteristics; ①disorder of neurotransmitter such asacetylcholine, ②forming of senile plaque caused by the accumulation of amyloid B
protein in the brain, ③accumulation of paired helical filament (PHF) that is composedof phosphoric tau protein or ubiquinone that is called neurofibrillary tangle
Among these, acetylcholine is secreted when the periodontal membrane is pushed bymastication stimulus and the stimulus is transmitted from the nerve in the dental pulp
to the brain.
It is reported that concentration of acetylcholine in the hippocampus decreased for the
rat whose back tooth was extracted.
From the examination of Alzheimer‟s brain condition with MRI at the time ofmastication, it has reported that activation was observed in frontal association area
where activity becomes low.

(7) I suppose you can understand how important it is for the dementia of Alzheimer typeto obtain sufficient chewing strength by placing an implant and having your own tooth.
In addition to the effect of making food delicious, implants have a big role in making thebrain fine and healthy.

Question 8
I understand that the periodontal disease is a cause of arteriosclerosis, cerebral
apoplexy, and dementia. Then, can the arteriosclerosis be a cause of heart disease or
hypertension which are caused by bad blood circulation? If so, in terms of protecting mefrom heart disease, dementia, and hypertension, is it more desirable to extract anaffected tooth early and place an implant than to cure the tooth?
Answer 8
The dental paradigm has shifted largely.
Up to now, treatment of teeth was thought to be enough in dentistry. However, we haveentered a new era where systemic diseases are cured and prevented in dentistry.
Dentists and patients have to deepen understanding of this fact.
Well, your question seems to be on the assumption that the periodontal disease isdifficult to be cured.
It is true that there is no definitive way to cure the periodontal disease completely atpresent.
I suppose you fear that, if the periodontal disease is difficult to be cured, thearteriosclerosis progresses and it might be a systemic problem during the progress of
periodontal disease.
It is true, so I will give you following explanation regarding this idea.
Firstly, I will explain a mechanism of the periodontal disease and the arteriosclerosis,
which are not generally known, as an important knowledge to guard our lives.
The arteriosclerosis is a disease that arterial walls become nonelastic and lumen ofblood vessels become narrow due to the thickness of the walls and deposition effect to its
interior.
Lumen becomes narrow due to the deposition of Atheroma which is mainly cholesterol,in the blood vessels, and it leads to deteriorate the blood circulation and sometimes it
stops.

Periodontal pathogens that invaded into tissues promote the production of activatedmacrophages from a monocyte, and low density lipoprotein (LDL) englobes in vascularwall and become foam cells that contain substantial lipid.
In a part where the foam cells proliferate, the cells degenerate gradually and form
extracellular lipid in the wall, therefore vascular walls expand towards inner side tolimit the blood circulation, and cause arteriosclerosis
If above mentioned mechanism progress to cause heart disease, cerebral apoplexy, anddementia from arteriosclerosis, it is not wrong idea to prevent the progress of
periodontal disease and if it cannot be done, extract the tooth to remove the cause.
However, I have to mention that decision should be made by patients because only they
can recognize subjective symptoms.
Question 9
In order to prevent dementia, cerebral apoplexy, and heart disease, I understand that it
is useful to extract an affected tooth at early stage and place an implant in cases when
the periodontal disease is unlikely to be cured. Is the periodontal disease related to any
other systemic diseases?
Answer 9
In fact, a new scientific knowledge has been generalized that the intraoral bacteria are
one of the causes of lifestyle related diseases.
(1) Oral health is deeply related to lifestyle related diseases such as obesity, diabetes,
heart disease, cancer, arteriosclerosis and cerebral apoplexy.
Generally, dental caries, periodontal disease, and various inflammations are examplesof oral diseases.
If you leave them as they are, for example, bad breath become worse, toothache andterrible swelling or inflammation will be caused, moreover it might lead to the toothloss.
(2) Recently, it has become clear that more than 500 kinds of pathogenic bacteria suchas bacteria of dental caries, periodontal pathogens, opportunistic pathogens, spirochete,
pseudomonas aeruginosa, and staphylococcus aureus inhabit in the oral and there are
more than 100 million pathogenic bacteria in 1 mg of plaque which are deeply related tolifestyle related diseases.
These intraoral bacteria and their substances are carried through the body and reaches
the various internal organs by blood flow and cause all sorts of diseases.
(3) However, this new knowledge is difficult to understand generally.
For instance, it is normal that people cannot easily image the relation between these
intraoral pathogenic bacteria and obesity because it is a common knowledge that excess
of calories is a cause of obesity.
Nevertheless, Gram-negative bacteria produce endotoxin and mainly lipopolysaccharide(LPS) that causes deposition of fat in the liver and fatty tissues to increase weight andto produces obesity.
A person who is easy to be fat although he/she does not eat too much should suspect if
he/she has a lot of gram-negative bacteria which consist endotoxin.
Obesity leads to insulin resistance caused by tumor necrosis factor- (TNF-) andpromotes progress of diabetes.
Conversely, if it is possible to make the oral clean and, for example, if periodontal
pathogens are removed, production of the TNF- will decline and insulin resistance will
be improved, as a result, glycemic control will become stable and diabetes will become
better.
(4) It became clear that there are close correlation between periodontal pathogens andinfluenza infection.
The patient with the periodontal disease gets influenza with a high probability.
Question 10
I have a daughter and I was concerned the problem of preterm low birth weight causedby the periodontal disease.
I have heard that if periodontal disease is progressed, it will be not cured since there isno special medicine for it. Therefore the cause had better to be removed by extracting a
tooth.
Some municipalities provide subsidy to let people to go to the dentist.
Is it that serious problem?
Answer 10
Preterm low birth weight is very serious problem.

(1) I will explain what preterm low birth weight is first. The premature baby imply tothe babies were born with a weight of less than 2,500 grams.
The premature baby has two big problems.
One is the problem that caused by brain damage.
For example, problems such as developmental disorder or neurological disorders (suchas cerebral palsy, mental retardation, visual impairment and hypacusis) occur with ahigh probability.
If these problems do not appear before a child is under school age, learning impairment
or behavior disorder will appear with a high probability after a child enters a school.
The other is that the premature baby is at high risk of getting lifestyle related diseases
such as obesity, diabetes, hyperlipidaemia and ischemic heart disease in the future.
I will explain why such things happen.
There are two mechanisms.
One of them is a mechanism of brain development that if necessary brain cells are notformed while a baby is in the womb, it is impossible to recover it after the birth.
Women were told to give birth with lower birth weight and make a baby grow. However,it has caused serious social problems (such as class disruption, attention-deficit
hyperactivity disorder (ADHD), increase of student in class for children with disability).
It became clear that when women give birth at early stage, it makes a baby`s brain to
not grow when it should in the womb, and the brain would not recover after its birth.
The other is that if a baby is in condition of undernutrition, a baby adapts to live under
this condition. As a result, the metabolic system developed during embryonic stages
under this condition will continue even after its birth.
The babies will be in the condition of good nutrition in the satiation of today`s society,consequently fat cells will become bigger and the babies will be easy to contract lifestyle
related diseases.
(2) In addition, it has become common sense that periodontal pathogens increase a riskof preterm low birth weight.
I will briefly explain it the following.
Causes of preterm low birth weight by periodontal disease are classified into two types.

One of them is direct participation of periodontal pathogens in obstetrical organs suchas womb. The other is inflammatory mediators (such as cytokine and prostaglandin)
which are produced by the body against periodontal pathogens.
If periodontal pathogens proliferate in the oral, some substances such as cytokine(transmitter) will be produced into blood by immunocompetent cells.
If cytokine and other substances are secreted excessively, inflammation will occur in theoral, gingiva and alveolar bone will be destroyed and periodontal disease will progress.
There are various cytokine and some of them are related to parturition.
Usually, substances (such as cytokine and prostaglandin) are produced after themother‟s body becomes ready for birth. However, periodontal disease also produces
these substances, therefore the mother`s body misunderstand it and triggers cervicalripening and uterine contraction to promote early parturition.
It is the preterm low birth weight.
Dysgenesis of premature babies will be a heavy burden on their lives.
Subsequently, I hope that young women recognize that to cure periodontal disease atdental clinic before becoming pregnant is responsible for their unborn babies.
Moreover, in regard to pregnant women, it should be understood that risk of periodontal
disease become higher due to the increase of female hormone.
Also, risk of periodontal disease gets dramatically higher because pregnant women tend
to fail in oral care due to morning sickness, etc.
For the reasons stated above, if you have daughters or granddaughters who are young,be sure to let them go the dentist.
If you are a young woman, examine whether you have periodontal pathogens or not in
the dental clinic for the sake of your unborn baby‟s future. If you have the pathogens,cure the disease and make the oral clean in order to make preparations to have ahealthy baby.
Let‟s protect future of unborn babies.
Question 11
What kind of risks are there in placing the long life implant?
Answer 11

I will explain general risks of placing implant at first.
Risks should be considered from three viewpoints, clinical skills of dentist,characteristics of implant body, and patient‟s condition of health around a tooth.
(1) Risk factor No.1. Clinical skills of dentist
It is the most important point to avoid failure of implant surgery.
Clinical skill is extremely varied by dentists.
Some of them are first-rate dentists, others are sued by patients because of failure of
implant placement although they appeal as if they are great doctors who have many
experiences.
For example, when an implant is installed obliquely when it should be installed
perpendicularly to the occlusal surface of tooth (where upper and lower teeth occludes),the implant would fall out because of the occlusal pressure (chewing strength).
Also, if the length of installed implant is long, it will fall out owing to the pressure from
opposing teeth (teeth that are opposite of upper of lower teeth)
In short, it means failure.
For instance, there is a technique to place an implant by increasing bone with anosteotome which uses a space of the paranasal sinus in order to thicken thin bone and to
install an implant into the maxilla (bone of the upper jaw).
It is an implant clinical technique called the socket lift procedure.
In this procedure, it is necessary to pull the schneiderian membrane (thin membrane
located between the paranasal sinus and the alveolar bone) up.
Some dentists make mistake of breaking through the membrane in implant surgery.
Moreover, slightly bigger crown will come off because of occlusal pressure (strength ofocclusion).
In addition, if implants cannot integrate with bone by osteoinduction that long life
implant can, there is a possibility that clearance would be made between the gingiva
and implant.
Then a risk of infection diseases gets higher.
If infection disease occurs, an implant will fall out and the treatment will result in
failure.
These problems would not happen if the dentist has high clinical skills.
Thus, it is necessary to choose the dentist who has high clinical skills of implant
placement to avoid failure of the first implant surgery.
Then how can we find the dentist with high clinical skills?

Being good at advertisement and have an excellent clinical skills is totally differentthing
I suggest you to get a recommendation of the dentist from someone such as friends or
acquaintances who has had an implant surgery.
They should introduce you a reliable dentist.
It will be fine because people who introduce you to the dentist have received implant
treatment by themselves and are sure that there was no failure.
The important thing is not to take whole information in books or advertisement on
trust.
So, what should you do if you cannot find anyone who has received implant surgery?
I believe that it is a great idea to get information from a society of people who received
the implant treatment.
If you wish to get some information I can tell you e-mail address of people who haveexperiences, so why don‟t you ask them directly?
I have been instructing dentists who perform implant surgeries and I have to add that
their clinical skills are depending on their talent.
Dentists who are highly talented in clinical skills can be a great doctor, but someuntalented dentists cannot hope for progress even if they receive many instructions.
(2) Risk factor No.2. Characteristics of implant body
In general, bio affinity power does not work for the first-generation implant body(bioinert) and it always at risk for fall out.
Next, in regard to the second generation implant body (bioactive) (such as an implant
body that coated by a hydroxyapatite with plasma spraying), it cannot be „one`s own
tooth‟ as long life can because high temperature (10,000 to 20,000 ℃) that plasma
spray makes destroys the condition of hydroxyapatite as explained above.
In short, some failures would generally occur in the long term.
(3) Risk factor No.3. Patients‟ own problems
In principle, there will be no risk if the patient is healthy.
In case where the patient has periodontal disease, an implant will be placed after the
disease is perfectly cured and making teeth clean, for that reason, this case will not a
problem.
In case of diabetes, a risk will get higher when first or second-generation implants areused. In general, implant treatment might be avoided depending on how diabetes andits complications progressed.

(4) Regarding the third-generation long life implant (AQB implant), it has been used
for many diabetics because the implant has characteristics to integrate with bone byosteoinduction.
Question 12
I understand that long life implant (AQB implant) becomes „my own tooth‟ and I think itmeans that the implant „integrates with the jawbone and becomes a part of the body‟.
I thought that was the one of a kind characteristic, but I found a section „implant which
integrates with bone‟ in the book on implants.
The implant`s name was „osseointegrated implant‟ and the book said that metal calledtitanium integrates with the human bone directly‟ and explained that „osseo‟ meansbone in Latin.
I have believed that „only long life implant can integrate with the bone and becomesone‟s own tooth‟ and „one of a kind‟. But is there any other implants which „can integratewith bone‟?
Please tell me the truth.
Answer 12
The explanation in the book is incorrect.
I will state that titanium cannot directly integrate with bone.
This is a general knowledge as shown in the passage from the Journal of the Tokyo
Dental College Society Vol.103.No.5 (2003)(Yoshinari M., Department of Dental
Materials Science of Tokyo Dental College) “in regard to osseointegration of titanium
implant, titanium does not directly integrate with bone, …. (p. 6 - 7),” “In this way,titanium implant integrates with the bone by forming amorphous structure in theinterface, so it is not direct integration with bone (p. 7).” This fact has been confirmed byother papers.
To begin with, titanium is metal and it does not basically have mechanism to integrate
directly with the body.
For that reason, technique such as apatite coating on titanium has developed and theapatite coated implants have been widely used.
If titanium can integrate directly with the bone, this kind of development andmanufacturing approach does not need to exist.
From this reason, it becomes clear that direct integration of titanium with bone does notexist.