京都大学大学院博士課程教育リーディングプログラム

充実した健康長寿社会を築く
総合医療開発リーダー育成プログラム
Training Program of Leaders for Integrated Medical
System for Fruitful Healthy-Longevity Society

平成26年度

年次報告書

Annual Report 2014

目 次Contents

はじめに ……………………………………………………………………… 2
Preface1.

プログラムの概要 …………………………………………………………… 6
Outline of the Program2.

教育カリキュラム及び指導体制 ………………………………………… 28
Curriculum and Staff

3.

国際連携 …………………………………………………………………… 60
International Cooperation

4.

学生の活動 ………………………………………………………………… 68
Student Activities5.

広 報 ……………………………………………………………………… 130
Public Relations

6.

産公学連携 ………………………………………………………………… 144
Industry-Public-Academia Cooperation

編集後記 …………………………………………………………………… 147
Postscript

1

ࡣࡌࡵ࡟
㸰㸮㸯㸳ᖺ㸱᭶㸱㸯᪥ ඘ᐇࡋࡓ೺ᗣ㛗ᑑ♫఍ࢆ⠏ࡃ⥲ྜ་⒪㛤Ⓨ࣮ࣜࢲ࣮⫱ᡂࣉࣟࢢ࣒ࣛ㸦Training
Programof

LeadersforIntegrated

MedicalSystemfor

Fruitful

Healthy-Longevity Society: LIMS㸧ࡣࠊ㡰ㄪ࡟ࡍ࡭ࡾࡔࡋ࡚࠸ࡿࡼ࠺࡟࠾ࡶ
ࢃࢀࡿࠋࡍࡄ࡟⤖ᯝࢆồࡵࡿࡢࡣ᪥ᮏேࡢᝏ࠸ᛶⒷ࡛࠶ࡿࡀࠊྍ⬟࡞㝈ࡾᏛ⩦ࡢ㏵୰࡟࠾࠸࡚ࡶࠊ་Ꮫⓗ▱㆑ࢆᛂ⏝ࡋࡓ♫఍࡬ࡢ㈉⊩ࡀ࡛ࡁࡿࡼ࠺࡞⎔ቃసࡾࢆᚰࡀࡅ࡚࠸ࡿࠋ ி኱⑓㝔ࡣࡌࡵࠊከࡃࡢ་Ꮫ㒊ࡢ᪉ࠎࡢ༠ຊࡸࠊᗈ࠸ព࿡࡛ࡢ་⒪⏘ᴗࢆ᥎㐍ࡍࡿ࢚ࢿࣝࢠ࣮ࡢ࠶ࡿ௻ᴗࡢ᪉ࡢᤵᴗ࡞࡝࡛ࠊᒚಟ⏕ࡢព㆑ᨵ㠉ࡀ㉳ࡇࡿࡇ࡜ࢆᮇᚅࡍࡿࡶࡢ࡛࠶ࡿࠋ་⒪⏘ᴗ࡜࠸࠺࡜ࠊ㧗ᗘඛ㐍་⒪ࢆᨭ࠼ࡿඛ
➃ᢏ⾡࡜ᛮࢃࢀࡀࡕ࡛࠶ࡿࡀࠊࡴࡋࢁࠊࡉࡲࡊࡲ࡞ᐇ⏕άࡢሙ㠃࡛ࠊ་Ꮫⓗ࡞▱㆑ࢆᛂ⏝ࡋ࡚ࠊ೺ᗣ࡞⏕άࡀ㏦ࢀࡿ⏕ά⎔ቃࢆ⏕ࡳฟࡍ௙⤌ࡳࢆ⪃࠼ࡿࡇ࡜࡛ࠊࡇࢀ࠿ࡽࡢ㛗ᑑ♫఍ࢆᏳᚰࡋ࡚㏄࠼ࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿ࡜࠾ࡶࢃࢀࡿࠋ ་⒪⏘ᴗࢆάⓎ໬ࡍࡿࡇ࡜ࡶ㔜せ࡛ࡣ࠶ࡿࡀࠊࡇࢀ࠿ࡽࡢᏳ඲࡛ᛌ㐺࡞⪁
ᚋࢆ㏦ࡿୡ௦࡟࡜ࡗ࡚ࠊ࡝ࢀࡃࡽ࠸ࠊ඘ᐇࡋࡓ⏕άࢆ㏦ࢀࡿ࠿ࢆࠊᐇឤ࡛ࡁ
ࡿ♫఍ࠊ♫఍࢖ࣥࣇࣛࡢᩚഛࡀ࡛ࡁࡿ࠿ࡀࠊ㔜せ࡛࠶ࡿࠋ ᖺᗘ㛤ദࡉࢀࡿ᪥ᮏ་Ꮫ఍⥲఍࡟࠾࠸࡚ࡶࠊ஭ᮧ఍㢌ࡢⓎ᱌࡛ࠊࡇࢀࡽࢆᐇ⌧࡛ࡁࡿᗈ࠸
ព࿡࡛ࡢ་ᕤ㐃ᦠࢆ᥎㐍ࡍࡿᇶ┙ࢆసࡾୖࡆࡿࡇ࡜ࡀィ⏬ࡉࢀ࡚࠸ࡿࠋࡇࢀ
ࡣࠊ⚾㐩ࡀ┠ᣦࡋ࡚࠸ࡓࡶࡢ࡜୍⮴ࡍࡿࡶࡢ࡛ࠊ✚ᴟⓗ࡞༠ຊయไ࡛⮫ࡴࡇ࡜࡟࡞ࡗࡓࠋ ࡇࢀࡽࡢάືࢆ㏻ࡋ࡚ࠊ᪂ࡋ࠸་ᕤ㐃ᦠ࡟ࡼࡿ⏘ᴗࠊᨻ⟇ࡀᐇ⾜ࡉࢀࢀࡤࠊ
඘ᐇࡋࡓ㛗ᑑ♫఍ࡢᐇ⌧ࡣ㞴ࡋ࠸ࡶࡢ࡛ࡣ࡞࠸࡜☜ಙࡋ࡚࠸ࡿࠋ
ࣉࣟࢢ࣒ࣛࢥ࣮ࢹ࢕ࢿ࣮ࢱ࣮
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2

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⚟ᒣ⚽┤

Preface

H.Fukuyama, M.D., Ph.D.
Coordinator of LIMS,
Director of Human Brain Research Center

Professor of Kyoto University Graduate School of Medicine

Training Program of Leaders for Integrated Medical System for Fruitful
Healthy-Longevity Society: LIMS has now started without major problems.
This program is designed to encourage the students from Engineering or otherfaculties to study basic medicine for creation of a new medico-engineeringcollaboration.
We do not target on a narrow sense of medico-engineering collaboration justfocusing on the development of machines for advanced medicine. Instead, we
aim at the innovation or revolutionary changes in lifestyle. Ingenious
integration of small but divers ideas originating from the students’engineering background but also applying their medical knowledge may
contribute to improve the living environments for healthy longevity.
In this context, we would like to expand the minds of the students toward awider sense of “longevity.” Supported by the staffs of Kyoto University
Hospital as well as the lecturers from various companies located in Japan andoverseas, the students will be able to put their medical knowledge into use toconsider how people can happily live in the aged society with respect to theirhealth and quality of life.
Professor Emeritus (Kyoto University) Hiroo Imura, the president of the
29th General Assembly of the Japan Medical Congress 2015 Kansai to beheld this April, announced his idea to build the necessary foundation topromote cooperation of medicine with various industrial fields for a
successful aging society. The LIMS program will cooperate to explore futuresystems from a standpoint of interdisciplinary education.
I believe these ideas are essential for the implementation of a fruitfulhealthy-longevity society.
March 31st, 2015.

3

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1.
プログラムの概要
Outline of the Program඘ᐇ䛧䛯೺ᗣ㛗ᑑ♫఍䜢⠏䛟⥲ྜ་⒪㛤Ⓨ䝸䞊䝎䞊⫱ᡂ䝥䝻䜾䝷䝮㻌㻌㸯㸬タ❧ࡢ┠ⓗୡ⏺ⓗ䛻ேཱྀ䛾㧗㱋໬䛜ᗈ䛜䜛୰䚸ୡ⏺᭱㛗䛾೺ᗣᑑ࿨䛸ඛ➃ⓗ◊✲㛤Ⓨ⬟ຊ䛸䛔䛖᮲௳䜢ྜ䜟䛫ᣢ䛴᪥ᮏ䛷䛿䚸㧗㱋໬♫఍䛾ၥ㢟䜢ಠ▔䛧䚸䝯䝕䜱䜹䝹䜲䝜䝧䞊䝅䝵䞁䜢㏻䛨䛶඘ᐇ䛧䛯೺ᗣ㛗ᑑ♫఍䜢㐩ᡂ䛩䜛ேᮦ䜢䚸ୡ⏺䛻㍮ฟ䛩䜛䛣䛸䛜ᛴົ䛸䛺䛳䛶䛔䜛䚹䛭䛣䛷ᮏ䝥䝻䜾䝷䝮䛷䛿䚸㧗㱋໬♫఍䛜ᢪ䛘䜛ၥ㢟䜢ಠ▔䛧䚸䊠㻚ᕤᏛᢏ⾡䜢་⒪䞉ᨭ᥼䝅䝇䝔䝮䜈㐺⏝䛧䚸䊡㻚་Ꮫ䛾୰䛻⵳䛘䜙䜜䛯▱㆑䜢ᕤᏛ䛻ά⏝䛩䜛䛸䛔䛖䠎᪉ྥ䛛䜙䚸ලయⓗ䛺ゎỴἲ䜢๰᱌䛧䚸඘ᐇ䛧䛯೺ᗣ㛗ᑑ♫఍䛾ᵓ⠏䛻ྥ䛡᥎㐍䛩䜛䛣䛸䛾ฟ᮶䜛䛂⥲ྜ་⒪㛤Ⓨ䝸䞊䝎䞊䛃䜢䚸␗ศ㔝䛾◊✲⪅䜢⤌䜏ྜ䜟䛫䛯⏘Ꮫᶓ᩿ⓗ䛺ᩍ⫱䝥䝻䜾䝷䝮䛻䛚䛔䛶⤌⧊ⓗ䛻⫱ᡂ䛩䜛䚹㻌䊠㻚㻌 ┿䛻་Ꮫ䞉་⒪䛜ศ䛛䜛་ᕤᏛேᮦ䛾⫱ᡂ㻌ᮏ䝥䝻䜾䝷䝮䛷䛿䚸ᕤᏛ⣔䛾䝥䝻䜾䝷䝮ᒚಟ⪅䛻ேయゎ๗Ꮫ䚸⏕⌮Ꮫ䚸⑓⌮Ꮫ䛺䛹䛾ᇶ♏་Ꮫᩍ⫱䛸⑓㝔ෆᐇ⩦䜢ㄢ䛧䚸」ᩘศ㔝䛾ᩍဨ䛻䜘䜛⥥ᐦ䛺ウㄽ䞉ᣦᑟ䜢⾜䛔䚸་Ꮫ㒊༞ᴗ⏕䛸ྠ➼䛾་Ꮫ䞉་⒪▱㆑䜢᭷䛩䜛་ᕤᏛேᮦ䜢⫱ᡂ䛩䜛䚹་⒪䞉ᨭ᥼⌧ሙ䛾ᐇ⩦䜔་⒪೔⌮Ꮫ䜢㏻䛨䚸฼⏝⪅䛻䛸䜚㈇ᢸ䛾ᑡ䛺䛔䛂㧗㱋⪅䛻ඃ䛧䛔䛃ᶵჾ䞉䝅䝇䝔䝮䜢㛤Ⓨ䛩䜛䝉䞁䝇䜢ᾰ㣴䛩䜛䚹་⒪⌧ሙ䛾䝙䞊䝈䜔་⒪⤒῭Ꮫ䞉チㄆྍไᗘ䛾▱㆑䛻ᇶ䛵䛝䚸ᶵჾ䞉䝅䝇䝔䝮䛾⏘ᴗ໬䞉ᕷሙ䛾ண⬟ຊ䜢㣴䛖䚹ᅜ㝿ᶆ‽໬䛾▱㆑䜔༟㉺䛧䛯䝁䝭䝳䝙䜿䞊䝅䝵䞁⬟ຊ䜢ഛ䛘䚸ᅜ㝿ᶆ‽໬ᶵᵓ䛺䛹䛷ά㌍䛷䛝䜛ேᮦ䜢⫱ᡂ䛩䜛䚹㻌䊡㻚㻌 ་Ꮫ䛾୰䛻⵳䛘䜙䜜䛯▱㆑䜢ከศ㔝䛻Ⓨᒎ䛥䛫䜛䝸䞊䝎䞊䛾⫱ᡂ㻌ୡ⏺䛾௚ᆅᇦ䛻ඛ㥑䛡䛶㧗㱋໬♫఍䜢㏄䛘䜛᪥ᮏ䛷䚸೺ᗣᑑ࿨䛜ୡ⏺᭱㛗䛷䛒䜛䛸䛔䛖⫼ᬒ䜢ά䛛䛧䚸㧗㱋⪅䛜⮬❧䛧䛶♫఍ཧຍ䛩䜛䛾䛻㐺䛧䛯♫఍䝅䝇䝔䝮䜔᪂⏘ᴗ䜢๰ฟ䛷䛝䜛ேᮦ䜢⫱ᡂ䛩䜛䚹᭦䛻䚸䛣䛾䇾᪥ᮏ䝰䝕䝹䇿䜢ඛ㐩䛸䛧䛶ୡ⏺䛾೺ᗣ㛗ᑑྥୖ䜢≌ᘬ䛷䛝䜛ேᮦ䜢⫱ᡂ䛩䜛䚹㻌䛣䜜䜙䊠㻚㻌 ཬ䜃䊡㻚䛾䝸䞊䝎䞊ேᮦ䜢㍮ฟ䛧䚸᪂䛯䛺Ꮫ㝿ⓗ◊✲㛤Ⓨ䛾᥎㐍䜢ྍ⬟䛸䛩䜛䛣䛸䛻䜘䛳䛶䚸㇏䛛䛺೺ᗣ㛗ᑑ♫఍䛾ᵓ⠏䛻㈉⊩䛩䜛䛣䛸䜢┠ⓗ䛸䛩䜛䚹㻌㻌ᮏ䝥䝻䜾䝷䝮䛾Ꮫၥศ㔝䛿䚸䛂་ᕤᏛ䛃䛷䛒䜚䚸䝥䝻䜾䝷䝮ᒚಟ⪅䛿䚸་Ꮫ◊✲⛉䚸ᕤᏛ◊✲⛉䚸⸆Ꮫ◊✲⛉䛾ఱ䜜䛛䛻ᒓ䛩䜛䛣䛸䛛䜙䚸ᕤᏛ㒊ฟ㌟⪅䚸䜎䛯䛿⏕≀㛵ಀᏛ㒊ฟ㌟⪅䛾ఱ䜜䛛䛜᝿ᐃ䛥䜜䜛䚹䛯䛰䛧䚸ฟ㌟Ꮫ㒊䜢㝈ᐃ䛩䜛䛣䛸䛿䛺䛔䚹ᕤᏛ㒊ฟ㌟⪅䛿䚸ᕤᏛ⪅䛸䛧䛶䛾ᐇຊ䜢᭷䛧䛛䛴་Ꮫ㒊Ꮫ⏕䛸ྠ➼䛺ேయ䞉⏕≀Ꮫ䛾▱㆑䜢᭷䛩䜛䛣䛸䚸䜎䛯⏕≀㛵ಀᏛ㒊䛾ฟ㌟⪅䛷䛿ᕤᏛ◊✲䛜⾜䛘䜛ᕤᏛ䛾ᑓ㛛ᛶ䛾㧗䛔▱㆑䜢ྲྀᚓ䛩䜛䛣䛸䜢┠ᣦ䛩䚹䝥䝻䜾䝷䝮䛿ㅮ⩏䚸₇⩦䞉ᐇ⩦䛸≉ู◊✲䛻䜘䜚ᵓᡂ䛥䜜䜛䚹㻌㻌㸰㸬࢔ࢻ࣑ࢵࢩ࣭࣏ࣙࣥࣜࢩ࣮
་ᕤ㐃ᦠ䛸䛔䛖䛣䛸䛜㔜せ䛷䛒䜛䛸ゝ䜟䜜䛶ஂ䛧䛔䚹䛧䛛䛧䚸ゝⴥ䛭䛾䜒䛾䛾ព࿡䛩䜛䛸䛣䜝䛿䚸་Ꮫ◊✲⪅䛸ᕤᏛ◊✲⪅䛜༠ຊ䛧ྜ䛔䚸䛒䛯䜙䛧䛔་⒪ᶵჾ䛺䜚䚸་⒪᪉ἲ䜢㛤Ⓨ䛩䜛䛸䛔䛖䛸䛣䜝䛻䛒䜚䚸䛩䛷䛻䛒䜛◊✲ᡂᯝ䜔ၥ㢟Ⅼ䜢༠ຊ䛧䛶ゎỴ䛧䛶䛔䛟䛸䛔䛖䛣䛸䛷䛒䛳䛯䚹㻌Ṕྐ䜢䛯䛹䜛䛸䚸⬻ື⬦⒗ᡭ⾡䛷᰿἞⒪ἲ䛸䛺䜛䝛䝑䜽䜽䝸䝑䝥䛜䛷䛝䛺䛔ሙྜ䚸ᡭ䛜╔䛡䜘䛖䛾䛺䛔䜒䛾䜢ື⬦⒗䛾ୖ䛛䜙᥋╔๣䛷ฟ⾑䛧䛺䛔䜘䛖䛻䛩䜛䛸䛔䛖Ⓨ᝿䜢⬻እ⛉䛛䜙ᣢ䛱䚸ᕤᏛ䛸ඹྠ䛧䛶䝡䜸䝪䞁䝗䛸䛔䛖䚸6‵Ẽ䛾䛒䜛⤌⧊䛷䜒᥋╔⬟ຊ䛾䛒䜛≉Ṧ䛺᥋╔๣䜢⪃᱌䛧䛶䚸⬻ື⬦⒗䛾ᡭ⾡䛾ᖜ䜢ᗈ䛢䜛䛣䛸䛻ᡂຌ䛧䛶䛔䜛䚹௨๓䛿䚸ᕤᏛ◊✲䛻ேయ䛾ᶆᮏ䛺䛹䜢ᣢ䛱㎸䜐䛣䛸䛿↓ㅛ䛻㏆䛔ヰ䛧䛷䛒䛳䛯䜘䛖䛷䛒䜛䛜䚸⌧ᅾ䛷䛿䚸ᙜ↛䛸ᛮ䜟䜜䛶䛔䜛䛣䛾䜘䛖䛺◊✲ᡂᯝ䜒ඛே䛾ከ䛟䛾ດຊ䛻䜘䜛䜒䛾䛷䚸䛧䛛䜒䚸◊✲⤌⧊䜢䜎䛯䛔䛷䛾◊✲䛸䛔䛖Ⅼ䛷㔜せ䛺䜒䛾䛷䛒䜛䚹㻌ᮏ䝥䝻䜾䝷䝮䛷䛿䚸䛣䛾䜘䛖䛺◊✲㡿ᇦ䜢㉸䛘䛯◊✲䜢⾜䛖䛰䛡䛷䛿䛺䛟䚸஫䛔䛻ᑓ㛛䛸䛩䜛◊✲㡿ᇦ䜢ᣢ䛱䚸䛭䜜䜢䜒䛸䛻᪂䛧䛔Ⓨ᝿䜢䛩䜛䛾䛷䛿䛺䛟䚸䛂་Ꮫ◊✲⎔ቃ䛾୰䛷ᕤᏛ䜢Ꮫ䜆䛃䛸䛔䛖䛥䜙䛻୍Ṍ㋃䜏㎸䜣
䛰Ⓨ᝿䛷䚸ᕤᏛ⣔䛾኱Ꮫ㝔⏕䛾◊✲䛾ሙ䜢་Ꮫ◊✲⛉䛾୰䛻䛚䛝䚸་Ꮫ◊✲䛭䛾䜒䛾䜢⾜䛖䛾䛷䛿䛺䛟䚸ᕤᏛⓗぢᆅ䛛䜙ぢ䛶᪂䛧䛟་Ꮫ䜈㈉⊩䛩䜛䛸䛣䜝䛜䛺䛔䛛䜢◊✲䛩䜛┠ⓗព㆑䜢ᣢ䛱䚸ᕤᏛ䛾ᇶ♏◊✲䛾䝖䝺䞊䝙䞁䜾䜢ཷ䛡䛴䛴䚸་Ꮫ䛾ᇶ♏䛛䜙⮫ᗋ䚸௓ㆤ䜎䛷䜢Ꮫ䜃䚸་Ꮫ䞉ᕤᏛ䛾ᇉ᰿䜢㉺䛘䛯᪂䛧䛔◊✲㡿ᇦ䜢㛤ᣅ䛧䛶䛔䛟䛣䛸䜢┠ⓗ䛸䛧䛶䛔䜛䚹㻌≉䛻䚸㧗㱋໬䛜㢧ⴭ䛻㐍䜣䛷䛔䜛᪥ᮏ䛷䚸㧗㱋⪅་⒪䞉௓ㆤ䛿㛗䛔೺ᗣ㛗ᑑ䜢㐩ᡂ䛩䜛䛻䛿ᚲ㡲䛾᮲௳䛾୍䛴䛷䛒䜛䛜䚸༢䛻䚸⑓㝔䛷⾜䛖་⒪䛰䛡䛷䛿䛺䛟䚸୍⯡ᐙᗞ䛻䜒䛳䛸䜒㏆䛔᥃䛛䜚௜䛡་䜈䛾ᨭ᥼䚸㛗
ᮇ⒪㣴᪋タ䛾䛒䜚᪉䛺䛹䚸་⒪タഛ䛾ๅ᪂䛸䛸䜒䛻䚸ᕤᏛⓗᡭἲ䜢䜒䛸䛻䛧䛶㧗㱋໬䛧䛯♫఍䜢ᨭ䛘䜛䛯䜑䛾䛥䜎䛦䜎䛺ᕤኵ䜢♫఍䛻ྥ䛛䛳䛶✚ᴟⓗ䛻Ⓨಙ䛷䛝䜛ேᮦ䜢⫱ᡂ䛧䛶䚸᪂䛧䛔་ᕤ㐃ᦠ䛾ጼ䛜♫఍䛻᭷ຠ䛻ᶵ⬟䛷䛝䜛䛣䛸䜢♧䛩䛣䛸䜢䚸䜒䛖୍䛴䛾኱䛝䛺┠ⓗ䛸䛧䛶䛔䜛䚹㻌䛣䛾䜘䛖䛺᪂䛧䛔⪃䛘᪉䜢䜒䛸䛻䚸௒ᅇ䛾䝥䝻䝆䜵䜽䝖䛜䝇䝍䞊䝖䛧䚸་Ꮫ◊✲⛉䛜୰ᚰ䛸䛺䛳䛶䚸ᕤᏛ◊✲⛉䜔෌⏕་⛉Ꮫ◊✲ᡤ䛾䝇䝍䝑䝣䛜༠ຊ䛧䛯యไ䜢స䜚䚸ୖグ䛾┠ⓗ䜢㐩ᡂ䛩䜉䛟䜹䝸䜻䝳䝷䝮䜢ᕤኵ䛧䛶䛔䜛䚹䛣䜜䜎䛷䛾኱Ꮫ㝔䛸␗䛺䜚䝸䞊䝕䜱䞁䜾኱Ꮫ㝔䛷䛿♫఍䛸䛾᥋Ⅼ䜢㔜ど䛧䛯ேᮦ⫱ᡂ䜢┠ⓗ䛸䛧䛶䛔䜛䛾䛷䚸ᗈ䛟ⱥㄒ䛻䜘䜛ウㄽ䞉䝕䜱䝧䞊䝖䛻䜘䜛⮬ศ䛾ពᛮ䛾Ⓨಙ⬟ຊ䛾㣴ᡂ䛸䚸♫఍䜢་⒪䛾ほⅬ䛛䜙ಠ▔䛩䜛་⒪⤒῭Ꮫ䛺䛹䚸་ᕤ㐃ᦠ䛰䛡䛻䛸䛹䜎䜙䛺䛔ᗈ䛔ୡ⏺ⓗど㔝䛻❧䛳䛯ேᮦ⫱ᡂ䜢┠ᣦ䛧䛶䛔䜛Ⅼ䛷䚸䛣䜜䛛䜙䛾㧗㱋♫఍䜈㈨䛩䜛ேᮦ䛾⫱ᡂ䛻ᙺ❧䛴䛸ಙ䛪䜛䜒䛾䛷䛒䜛䚹㻌㸱㸬ᩍ⫱࣒࢝ࣜ࢟ࣗࣛ
㸦㸯㸧୍㈏ᩍ⫱ᮏ䝥䝻䜾䝷䝮䛿༤ኈㄢ⛬ᩍ⫱䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮䛸䛧䛶୍㈏䛧䛯኱Ꮫ㝔ᩍ⫱䜢⾜䛖䚹ᮏ䝥䝻䜾䝷䝮䛾ᒚಟ⪅䛾ཷධ㐣⛬䛸䛧䛶䚸ඛ䛪ᡤᒓ◊✲⛉䛸䛺䜛ᮏᏛ་Ꮫ◊✲⛉䠄་⛉Ꮫᑓᨷ䞉ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ䠅䞉ᕤᏛ◊✲⛉䞉⸆Ꮫ◊✲⛉䛾ಟኈㄢ⛬䛾ධᏛヨ㦂䜎䛯䛿་Ꮫ◊✲⛉䠄་Ꮫᑓᨷ䠅༤ኈㄢ⛬䛾ධᏛヨ㦂䜢ཷ㦂䛧䚸ྜ᱁䛩䜛䛣䛸䜢๓ᥦ䛸䛩䜛䚹䛯䛰䛧䚸䛣䜜䜙䛾Ꮫ㒊䜔ி㒔኱Ꮫ䛾ฟ㌟⪅䛷䛒䜛ᚲせ䛿䛺䛟䚸␃Ꮫ⏕䜒✚ᴟⓗ䛻ཷ䛡ධ䜜䜛䚹㻌♫఍ே⤒㦂⪅䛾ᒚಟ䜒チྍ䛩䜛䛜䚸ᮏ䝥䝻䜾䝷䝮䛷䛿䛛䛺䜚䝝䞊䝗䛺ᩍ⫱䝥䝻䜾䝷䝮䜢ㄢ䛩䛾䛷䚸Ꮫᴗ䛻ᑓᛕ䛷䛝䜛⎔ቃస䜚䜢ᡤᒓ௻ᴗ䞉⤌⧊䛸䛾㛫䛷༠㆟䛾䛖䛘㑅ᢤ䛩䜛䚹㻌㻌㸦㸰㸧ᒚಟ⛉┠㛤タ⛉┠ࡢᴫせࡣ௨ୗࡢ㏻ࡾ࡛࠶ࡾࠊಟኈㄢ⛬ಟ஢࡟ࡣࠊᣦᐃࡉࢀࡓᚲಟ⛉┠㸯㸱༢఩ࢆᚲࡎಟ
ᚓࡍࡿࡇ࡜㸦ᖹᡂ㸰㸳ᖺᗘᒚಟ⏕ࡣࠊ㸯㸰༢఩㸧ࡀᚲせ࡛࠶ࡿࠋࡲࡓࠊ༤ኈᚋᮇㄢ⛬࡛ࡣࠊ࢖ࣥࢱ
࣮ࣥࢩࢵࣉ㸦ᾏእ࢖ࣥࢱ࣮ࣥࢩࢵࣉ࡜௻ᴗ࢖ࣥࢱ࣮ࣥࢩࢵࣉࡢᑡ࡞ࡃ࡜ࡶ࠸ࡎࢀ࠿ᚲಟ㸧ࠊࣉࣞࣜࢧ࣮ࢳࠊ≉ู◊✲ࢆಟᚓࡍࡿࡇ࡜ࡀᚲせ࡛࠶ࡿࠋ7ᇶ┙⛉┠
ᕤᏛࠊ⸆Ꮫࠊ་Ꮫ࣭⏕≀Ꮫ་ᕤᏛ㡿ᇦࡢ◊✲࡟ᚲせ࡜࡞ࡿᕤᏛࠊ་Ꮫࠊ⸆Ꮫ࡟㛵ࡍࡿᇶ♏▱㆑ࢆ⩦ᚓࡍࡿࠋᕤᏛ㒊ฟ㌟⪅
࠿⏕≀㛵ಀᏛ㒊ฟ㌟ྥࡅࡢᶆ‽ᒚಟ࣓ࢽ࣮ࣗࢆᥦ♧ࠋࡑࢀࢆཧ⪃࡟⛉┠ࢆ㑅ᢥࡍࡿࠋ
་⒪೔⌮
་⒪೔⌮࡟ࡘ࠸࡚Ꮫ⩦ࡍࡿࠋᩘ⌮⛉Ꮫࢩ࣑࣮ࣗࣞࢩࣙࣥࢆ୰ᚰ࡜ࡋࡓࡶࡢ࡛ࠊᮏࣉࣟࢢ࣒࡛ࣛࡣࠊ་⒪⤒῭Ꮫ࡜࡜ࡶ࡟㧗㱋໬♫఍ࡢᑗ᮶ண ➼࡟ᚲせ࡞㔜せ࡞⛉┠࡜ࡋ࡚఩⨨௜ࡅࡿࠋ་⒪⤒῭Ꮫ
㧗㱋໬♫఍࡟࠾ࡅࡿ་⒪⤒῭Ꮫⓗㄢ㢟ࠊ▱ⓗ㈈⏘ࠊᅜ㝿ᶆ‽໬ࡢ⌮ゎຊࢆ㌟࡟௜ࡅࡉࡏࡿࠋ
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་⒪ᕤᏛ≉ูㅮ⩏༠ຊ௻ᴗ࠿ࡽὴ㐵ࡉࢀࡓㅮᖌ࡟ࡼࡾࠊ་⒪࣭೺ᗣ࣭ࢣ࢔࡞࡝࡟㛵ࡋࠊ᭱ඛ➃ࡢᢏ⾡ࡸ⌧ሙࡢㄢ㢟➼࡟ࡘ࠸࡚ㅮ⩏ࢆཷࡅࠊ㆟ㄽࡍࡿࠋ
Ꮫ㝿ᛂ⏝⛉┠≉ู◊✲࡛⾜࠺◊✲㡿ᇦ࡟ᛂࡌ࡚⏝ពࡉࢀࡓᑓ㛛⛉┠
ⱥㄒ GHEDWHᅜ㝿ⓗ࣮ࣜࢲ࣮࡟୙ྍḞ࡞⬟ຊ࡜ࡋ࡚ⱥㄒ࡛ࡢࢥ࣑ࣗࢽࢣ࣮ࢩࣙࣥຊࢆ㣴࠺ࠋ࢖ࣥࢱ࣮ࣥࢩࢵࣉ
௻ᴗ࡟࠾࠸࡚ࠊ◊✲㛤Ⓨ࡞࡝࡟ࡘ࠸࡚ࠊᐇ㊶ࡋ࡞ࡀࡽ⌮ゎࡋࠊ≉ู◊✲࡟ά࠿ࡍࠋ⾜ᨻᶵ㛵ࠊᅜ㝿ᶵ㛵࡟▷ᮇ◊ಟࢆ⾜࠸ࠊチㄆྍࡸᅜ㝿ᶆ‽໬ࡢ௙⤌ࡳࠊㄢ㢟࡟ࡘ࠸࡚⌮ゎࢆ῝ࡵࡿࠋࣉࣞࣜࢧ࣮ࢳ
◊✲ᐊ࣮ࣟࢸ࣮ࢩࣙࣥ࡞࡝ࢆ㏻ࡌࠊᑓ㛛௨እࡢศ㔝࡟㛵ࡍࡿ⌮ゎࢆᗈࡆࡿࠋ◊✲⪅࡜ࡋ࡚ࡢᇶ♏⬟ຊࢆ㣴࠸≉ู◊✲ࡢ◊✲ィ⏬ࢆసᡂࡍࡿࠋ
≉ู◊✲ࣉࣞࣜࢧ࣮ࢳ࡛సᡂࡋࡓ◊✲ィ⏬࡟ᇶ࡙࠸࡚༤ኈࡢ◊✲ࢆ㐙⾜ࡋࠊᏛ఩ྲྀᚓ࡜࣮ࣜࢹ࢕ࣥࢢࣉ
ࣟࢢ࣒ࣛࡢಟ஢ࢆ┠ᣦࡍࠋ㸦㸱㸧◊✲ᣦᑟ
ྛᒚಟ⪅䛻ᑐ䛧䛶䚸ᣦᑟᩍဨཬ䜃䝯䞁䝍䞊䜢㑅௵䛧ᣦᑟ䛻ᙜ䛯䜛䚹㻌ᣦᑟᩍဨ䠖ᅾ⡠䛩䜛◊✲⛉䛾ᩍဨ䛾䜋䛛䛻ᮏ䝥䝻䜾䝷䝮ᢸᙜᩍᤵ䛛䜙 㻝 ྡ䜢㑅௵䛩䜛䚹㻌

8䝯䞁䝍䞊ᩍဨ䠖␗䛺䜛ศ㔝䛛䜙䛾䝯䞁䝍䞊䜢ᑡ䛺䛟䛸䜒䠎ྡ㑅௵䛩䜛䚹㻌ᣦᑟᩍဨ䛿䚸Ꮫᖺẖ䛻ྛᒚಟ⪅䛻䛴䛔䛶䚸◊✲ᣦᑟグ㘓᭩䜢సᡂ䛩䜛䚹㻌㸦㸲㸧ᮏࣉࣟࢢ࣒ࣛࡢಟ஢せ௳㸿㸬ಟኈㄢ⛬䐟ᮏ䝥䝻䜾䝷䝮䛜タ䛡䜛䜹䝸䜻䝳䝷䝮䛻ᇶ䛵䛝ᚲせ䛺༢఩ᩘ䜢ಟᚓ䛧䚸䛛䛴䚸ᅾ⡠䛩䜛◊✲⛉䛜ᐃ䜑䜛ಟኈㄢ⛬䛾ಟ஢せ௳䜢‶䛯䛩䛣䛸䚹㻌䐠㐍Ꮫᑂᰝ㻌
ᮏ䝥䝻䜾䝷䝮䛷䛿䚸㻞 ᖺḟಟ஢᫬䛻༤ኈㄽᩥ◊✲ᇶ♏ຊᑂᰝ䠄䠭䠡䠅䛻䜘䜚䚸୰㛫ホ౯䜢⾜䛖䚹㻌䠍䠅་⛉Ꮫ䞉ே㛫೺ᗣ⛉Ꮫ䞉ᕤᏛ䞉⸆⛉Ꮫ➼䚸ᑓ㛛ศ㔝䛾▱㆑䛸⬟ຊ䚸ཬ䜃㛵㐃ศ㔝䛾ᇶ♏ⓗ⣲㣴䛻䛴䛔䛶ⱥㄒ䝺䝫䞊䝖䜢ᥦฟ䛥䛫䜛䚹㻌䠎䠅༤ኈㄽᩥ䛻㛵䜟䜛◊✲䜢⾜䛖≉ู◊✲ㄢ⛬䠄㻟 ᖺḟ䡚㻡 ᖺḟ䠅䛾◊✲ィ⏬䠄㻝䞉㻞 ᖺḟ䛾䛂䝥䝺䝸䝃䞊䝏䛃䛻䛶సᡂ䠅䜢ᥦฟ䛥䛫䜛䚹㻌䠏䠅◊✲ィ⏬䛻䛴䛔䛶ཱྀ㢌ヨၥ䜢⾜䛖䚹䝥䝻䜾䝷䝮ධ㐍Ꮫᑂᰝጤဨ఍䛜䚸䝯䞁䝍䞊䠄䝥䝻䜾䝷䝮≉ᐃᩍဨ䠅㻞ྡ䚸䝥䝻䜾䝷䝮䛾ᣦᑟᩍᤵ 㻝 ྡ䚸䝥䝻䜾䝷䝮ᢸᙜ䛾ᩍᤵ 㻝 ྡ䚸ィ 㻠 ྡ䜢㑅௵䛧ᐇ᪋䛩䜛䚹㻌䠐䠅ⱥㄒ 㼐㼑㼎㼍㼠㼑 ຊ䛾ホ౯䜢⾜䛖䚹㻌䛣䜜䜙䐟䛾せ௳䜢‶䛯䛧䚸䐠䛾⤖ᯝ䛻ᇶ䛵䛝䚸ᮏ䝥䝻䜾䝷䝮䛻䛚䛡䜛ಟኈㄢ⛬ಟ஢䛾ྍྰ䜢䚸ධ㐍Ꮫᑂᰝጤဨ఍䛜⥲ྜⓗ䛻ุᐃ䛩䜛䚹㻌ᇶ♏Ꮫຊ䛾⩦ᚓ䛜୙༑ศ䛸ุᐃ䛥䜜䛯⪅䛻䛴䛔䛶䛿䚸䜒䛖 㻝 ᖺ䚸୙㊊䛩䜛㒊ศ䛾෌ᒚಟ䜢⾜䜟䛫䜛䚹䜎䛯䚸≉ู◊✲䛾◊✲ィ⏬䛻⍗⑅䛜䛒䜛ሙྜ䚸ᡂᯝ䛜༑ศ䛻ぢ㎸䜑䛺䛔䛸ุ᩿䛧䛯ሙྜ➼䛿䚸෌ᥦฟ䜢ồ䜑䜛䚹䛭䛾㝿䚸䝯䞁䝍䞊䛜ᚲせ䛺䝃䝫䞊䝖䜢⾜䛖䚹㻌㹀㸬༤ኈᚋᮇㄢ⛬༤ኈᏛ఩䛾ᑂᰝ䛻䛴䛔䛶䛿䚸Ꮫ⏕䛛䜙䛾ᑂᰝㄳồ䛻ጞ䜎䜚䚸ᅾ⡠◊✲⛉ᩍᤵ఍䛛䜙䛾౫㢗䜢ཷ䛡䚸䜎䛪䝥䝻䜾䝷䝮䛾ಟ஢ᑂᰝጤဨ఍䛷ᑂᰝ䜢⾜䛖䚹䛣䛾㝿䚸ⱥㄒ䛷䛾㻌 㼐㼑㼎㼍㼠㼑㻌 ⬟ຊ䛾ホ౯䜢ⱥㄒ䜢ẕᅜㄒ⛬ᗘヰ䛩ᩍဨ䜔Ꮫෆ◊✲⪅䛻䜘䜚ཝᐦ䛻⾜䛖䚹ḟ䛔䛷䚸඲Ꮫ䛾༤ኈㄢ⛬ᩍ⫱䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮㐠Ⴀጤဨ఍䛜ಟ஢ㄆᐃ䜢⾜䛖䚹䛭䛾⤖ᯝ䜢䚸ᅾ⡠◊✲⛉ᩍᤵ఍䜈ሗ࿌䛩䜛䚹㻌㻌㸦㸳㸧ᚓࡽࢀࡿᏛ఩
㸿㸬ಟኈㄢ⛬ಟኈㄢ⛬ಟ஢⪅䛾ಟኈྕᤵ୚䛿䚸ྛᡤᒓ◊✲⛉䛾ุ᩿䛻ᚑ䛖䚹㻌㹀㸬༤ኈᚋᮇㄢ⛬ᡤᒓ◊✲⛉䛻䜘䜚䚸䛭䜜䛮䜜ḟ䛾㏻䜚䛸䛺䜛䚹㻌༤ኈ䠄་⛉Ꮫ䠅䚸༤ኈ䠄ே㛫೺ᗣ⛉Ꮫ䠅䚸༤ኈ䠄་Ꮫ䠅䚸༤ኈ䠄ᕤᏛ䠅䚸༤ኈ䠄⸆⛉Ꮫ䠅䛭䜜䛮䜜䛻⥆䛔䛶䚸䛂ᮏᏛ඘ᐇ䛧䛯೺ᗣ㛗ᑑ♫఍䜢⠏䛟⥲ྜ་⒪㛤Ⓨ䝸䞊䝎䞊⫱ᡂ䝥䝻䜾䝷䝮䜢ಟ஢䛧䛯䛣䛸䜢ド䛩䜛䛃䛸௜グ䛥䜜䜛䚹㻌㸦㸴㸧ࢹ࢕ࣉ࣐࣏ࣟࣜࢩ࣮

9་Ꮫⓗ▱㆑䜢༑ศ䛻Ꮫ⩦䛧఍ᚓ䛧䛯䚸་⛉Ꮫ䞉ᕤᏛ䞉⸆Ꮫ䛺䛹䛾ᐇ㦂䞉◊✲䛜䛷䛝䜛◊✲⪅䛷䚸ᾏእ䛾◊✲᪋タ䞉௻ᴗ䞉බඹ⤌⧊䛺䛹䛷ά㌍䛷䛝䜛䜘䛖༑ศ䛺ⱥㄒຊ䞉䝕䜱䝧䞊䝖ຊ䜢䜒䛱䚸඲ୡ⏺ⓗ䛻㐍⾜䛩䜛㧗㱋♫఍䛾⌧≧䛸ᑗ᮶䜢⮬ศ䛷ಠ▔ⓗ䛻⪃ᐹ䛧䚸ከᵝ䛺ே䜔⤌⧊䛸༠ຊ䛧䛶ၥ㢟Ⅼ䜢ゎỴ䛩䜛䛯䜑䛻䚸䛥䜎䛦䜎䛺⮬ศ䛾▱㆑䛸ᡭἲ䜢⏝䛔䜛䛣䛸䛜䛷䛝䚸㧗㱋⪅䛜Ᏻᚰ䛧䛶⏕ά䛷䛝䜛⎔ቃ䜢స䜚ୖ䛢䜙䜜䜛ே≀䛻䛺䜚䚸䛛䛛䜛ศ㔝䛻䛚䛡䜛᪥ᮏ䚸䜰䝆䜰䚸ୡ⏺䛾䝸䞊䝎䞊䛸䛺䜛䛣䛸䚹㻌㸦㸵㸧࣏࣮ࢺࣇ࢛ࣜ࢜
䝥䝻䜾䝷䝮ᒚಟ⪅䛿䚸ᒚಟ䞉ᡂ⦼䞉㐩ᡂᗘ䛾⮬ᕫⅬ᳨䚸ᩍဨ䛻䜘䜛ホ౯䜢┠ⓗ䛸䛧䛶䚸䝫䞊䝖䝣䜷䝸䜸䜢సᡂ䛩䜛䛣䛸䛜ồ䜑䜙䜜䜛䚹ᒚಟ⪅䛿䚸䝫䞊䝖䝣䜷䝸䜸䜢ᣦ♧䛥䜜䛯᫬䜎䛷䛻㐺ᐅ᭦᪂䛧䚸ᣦᑟᩍဨ➼䛾㜀ぴ䛻౪䛧䛺䛡䜜䜀䛺䜙䛺䛔䚹䝫䞊䝖䝣䜷䝸䜸䛿䚸㐍Ꮫᑂᰝ䞉≉ᚅ⏕ዡບ㔠䛾⥅⥆ᑂᰝ➼䛾ホ౯䛾୍㒊䛸䛧䛶฼⏝䛥䜜䜛䚹㻌
㻌㸲㸬ᒚಟ⪅࡬ࡢᨭ᥼
䝥䝻䜾䝷䝮ᒚಟ⪅䛻䛿䚸䝸䞊䝕䜱䞁䜾༤ኈㄢ⛬䛻䛚䛡䜛ᒚಟཬ䜃Ꮫ఩◊✲䛻ᑓᛕ䛩䜛䛯䜑䛾௨ୗ䛾䜘䛖䛺⤒῭ᨭ᥼䜢⾜䛖䚹㻌‫≉۔‬ᚅ⏕ዡບ㔠௨ୗࡢཷ⤥㈨᱁ࢆࡍ࡭࡚‶ࡓࡍඃ⚽࡞ᒚಟ⪅࡟ᑐࡋ࡚≉ᚅ⏕ዡບ㔠ࢆᨭ⤥ࡍࡿࠋᨭ⤥㢠ཬࡧᨭ⤥⥅⥆࡟ࡘ࠸࡚ࡣࠊ㑅ᢤ᫬ཬࡧྛᏛᖺᮎ࡟Ỵᐃࡉࢀࠊᖺᗘࡈ࡜࡟ぢ┤ࡉࢀࡿࠋࡲࡓࠊዡບ㔠ཷ⤥⪅ࡢẶྡࡣཷ⤥㛤ጞ๓࡟Ꮫෆᥖ♧ཬࡧ㹊㹇㹋㹑࣮࣒࣮࣍࣌ࢪ࡟࡚බ⾲ࡍࡿࠋ䛆ཷ⤥㈨᱁䛇㻌 㻌㻔㻝㻕㻌 䝥䝻䜾䝷䝮ᒚಟ⪅㑅ᢤヨ㦂䛻ྜ᱁䛧䛯ᮏ䝥䝻䜾䝷䝮䛾ᒚಟ⪅㻌 㻌㻔㻞㻕㻌 ྛ✀ዡᏛ㔠➼䛾ᑵᏛᨭ᥼⤒㈝䠄ᮏᏛ䛾ᐃ䜑䜛ᤵᴗᩱ➼ච㝖䛿㝖䛟䠅䜢ཷ䛡䛶䛔䛺䛔⪅㻌 㻌䛯䛰䛧䚸ᅜ㈝␃Ꮫ⏕➼䛷ᮏዡບ㔠䜢㎡㏥䛧䛯⪅䛿䚸௚䛾ዡᏛ㔠䜢ཷ䛡䛺䛜䜙ᮏ䝥䝻䜾䝷䝮㻌䜢ᒚಟ䛩䜛䛣䛸䛜䛷䛝䜛䚹㻌 㻌㻔㻟㻕㻌 ዡບ㔠௨እ䛾཰ධ䠄䜰䝹䝞䜲䝖䛾⤥୚➼䠅䜢ᚓ䛶䛔䛺䛔⪅㻌 㻌䛯䛰䛧䚸◊✲ᡂᯝ䛾බ⾲䛻క䛖ㅰ㔠䚸ⴭసᩱ䛚䜘䜃 㼀㻭䞉㻾㻭 䛾⤥୚䠄ᮏ䝥䝻䜾䝷䝮䛻䛚䛔䛶㻌ᮏ䝥䝻䜾䝷䝮䛾ᐇ᪋䛻୙ྍḞ䛸ุ᩿䛥䜜䜛ሙྜ䛻㝈䜚䚸㐌䠑᫬㛫䜢ୖ㝈䛸䛩䜛䚹䠅➼䛻㝈䜚䚸㻌䛣䜜䜢㝖እ䛩䜛䚹㻌 㻌㻔㻠㻕㻌 ᮏᏛ኱Ꮫ㝔䛾ᅾ⡠ᮇ㛫䠄ఇᏛᮇ㛫䜢㝖䛟䠅䛜䠑ᖺ䜢㉸䛘䛺䛔⪅㻌 㻌㻔㻡㻕㻌 ᮏ䝥䝻䜾䝷䝮䛻䛚䛡䜛ᡂ⦼➼ホ౯䛻䛚䛔䛶≉䛻ඃ⚽䛸ㄆ䜑䜙䜜䜛⪅㻌 㻌㻔㻢㻕㻌 ᮏ䝥䝻䜾䝷䝮䛜䠑ᖺ୍㈏䛾ᩍ⫱◊✲ㄢ⛬䛷䛒䜛䛣䛸䜢஢ゎ䛩䜛⪅㻌 㻌㻌䛆ཷ⤥㈨᱁䛾႙ኻ᮲௳䛇㻌 ཷ⤥⪅䛜ḟ䛾ྛྕ䛾୍䛻ヱᙜ䛩䜛ሙྜ䛿䚸䛭䛾㈨᱁䜢ኻ䛖䚹㻌 㻌㻔㻝㻕㻌 ୖグ䛻ᐃ䜑䜛ཷ⤥㈨᱁䜢ኻ䛳䛯䛸䛝䚹㻌 㻌㻔㻞㻕㻌 ཷ⤥⪅䛛䜙䛾㎡㏥ᒆ䛜ཷ⌮䛥䜜䛯䛸䛝䚹㻌 㻌㻔㻟㻕㻌 ዡບ㔠䛻䛴䛔䛶ᥦฟ䛥䜜䛯᭩㢮䛻⹫ഇ䛾グ㍕䛜䛒䜛䛸䛝䚹㻌 㻌㻔㻠㻕㻌 ఇᏛཪ䛿㏥Ꮫ䛧䛯䛸䛝䚸䛚䜘䜃㝖⡠䛥䜜䛯䛸䛝䚹㻌 㻌㻔㻡㻕㻌 ி㒔኱Ꮫ㏻๎䛾つᐃ䛻䜘䜚ᠬᡄฎศ䜢ཷ䛡䛯䛸䛝䚹㻌 㻌
㻌

10

以上

Training Program of Leaders for Integrated Medical System
for Fruitful Healthy-Longevity Society

1. Purpose
In an era of global aging, there is an urgent need in Japan, with its people having the longest healthy
life expectancy and with its advanced research and development technology, to foster worldwide
human resources able to understand the problems of an aging society, and to lead medical innovation
globally supporting a fruitful, healthy-longevity society. Thus, this program will reanalyze theproblems of an aging society and systematically mentor “Leaders for Integrated Medical Development
Systems” with an industry-university educational program. This program will train researchers fromdifferent fields, who can respond to the problems and advance us to the establishment of a fruitfulhealthy-longevity society, through a bidirectional point of view: I. applying engineering to medical
support systems, II. improving engineering with knowledge from the medical sciences.
I. Medico-engineering leaders who fully understand medical practiceThis program will provide basic medical education (human anatomy, physiology, pathology) andhospital practice for students with engineering backgrounds, thorough discussion and guidance byteaching-staff from different fields. Consequently, the program fosters medico-engineering leaders withmedical knowledge equivalent to medical school graduates. Through hands-on experience in
medical/support care and comprehension of health-care ethics, students will cultivate a sense of how todevelop “elderly-friendly” devices and low burden systems for the users. Based on their understandingof the specific needs in medical practice, and the knowledge of health economics and the licensing
system, students will be able to predict industry and market trends on devices and systems. Students
will be trained in international standardization, develop professional communication skills and play
globally active roles in settings such as the International Organization for Standardization.
II. Leaders who can extend medical knowledge to different fields
Japan is one of the first countries to face the problem of an aging society. Taking advantage of theworld’s longest life expectancy, the program will train leaders who can develop new industries andsocial systems enabling the elderly to engage actively in community life. These leaders will help
improve life expectancy globally using this “Japan model” as a precedent.
The ultimate goal of this program is to help in coordinating a fruitful healthy-longevity society bytraining these leaders with I. and II. , resulting in advances of international research development.
The discipline of this program is “medico-engineering”, meaning a collaboration program of the
Graduate School of Medicine, Graduate School of Engineering, and Graduate School of
Pharmaceutical Science, so we expect that most students will be graduates from the above-related
departments, but there is no limitation on the background of their undergraduate departments.
Engineering graduates will acquire highly specialized knowledge of the human body and biology,
comparable with graduates from the medical department. Biology-related graduates will acquire highly
specialized knowledge in engineering, comparable with graduates from the engineering department,
and will be able to conduct engineering research. The program comprises lectures, exercises, training
and specific research.

112. Admission Policy
The importance of medico-engineering collaboration has been discussed for a long time. However,
the intended meaning of the word itself is just that medical and engineering researchers work together
to develop novel devices and methods of medical treatment, to apply the results and to overcome
existing problems. Looking back into history, when a neck clip could not be used as a radical therapy in
cerebral aneurysms, neurosurgeons came up with the idea to seal these inoperable aneurysms with glue.
Through cooperation with engineering researchers, “Biobond”, a bonding agent which can produce
strong adhesion even between moist human tissues, was developed and succeeded in expanding theapplication of operable aneurysms. The idea of applying engineering research to the human body wasconsidered ridiculous in the past, but it has become widely accepted nowadays due to the tremendous
efforts of the pioneers in this field. In addition, this form of interdisciplinary collaboration has become
important in terms of research across different research organizations. This program performs not only
research extending beyond fields, but goes mutually between different fields, by bringing new ideas
from each field, and by applying the concept of “learn engineering in a medical research environment”.
In this way, graduate students with engineering backgrounds, not only perform medical research in a
medical environment, but also seek novel ways in which engineering can contribute to medicine. Withbasic knowledge in medicine and medical care fostered in this program, together with alreadycultivated knowledge in engineering, the students will open up a new frontier in medico-engineeringresearch. In particular, the advanced progress of unprecedented aging in Japan requires adequate
medical treatment and nursing care as essential conditions to achieve healthy longevity. However, froman engineering point of view, it is necessary to show that this new medico-engineering collaboration
will function effectively by training leaders who can actively disseminate their developments to thesociety by not only simply practicing medical care in hospitals, but also by supporting a family doctor
system near each home, reconsidering long-term care facilities, and supporting an aged society with a
new medical system.
Under these new concepts, the project has started with a central role of the Graduate School of
Medicine in collaboration with staff from the Graduate School of Engineering and the Institute for
Frontier Medical Sciences, creating a suitable curriculum to achieve the above-mentioned aims. Unlike
any of the existing graduate schools, the Leading Graduates Schools aim at training leaders and put
special emphasis on interaction with the society. We believe that these students will develop abilities toexpress their ideas through discussion and debate in English. They will be able to look at society trends
from a medical and medical economics point of view. Finally, they will develop a broad global
perspective which is not only limited to medico-engineering cooperation. We believe these leaders will
make a contribution to the aging society in the future.

3. Curriculum(1) Continuous education
This program provides consistent graduate education as “Program for Leading Graduate Schools”.
In order to be enrolled in this program, first, the students have to take and pass the entrance
examination for Master’s course of Kyoto University at one of the following Graduate Schools:
Graduate School of Medicine (Medical Science Major, Human Health Science Major), Graduate
School of Engineering, Graduate School of Pharmaceutical Sciences, or, the entrance examination for
the Doctoral Program in Medicine of the Graduate School of Medicine of Kyoto University. However,12

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13

Thesis Research
Conduct Doctoral thesis research based upon the research plan prepared in the Pre-research
period. The final goal is acquiring a Ph.D. degree and graduation from the program.
(3) Research training
A teaching advisor and mentors are chosen to guide each student.
Teaching advisor: A professor of the affiliated graduate school which the students belong to or aprofessor of the program is chosen.
Mentors: At least two are chosen from different fields.
Teaching advisors and mentors must fill out an annual teaching record for each student.
(4) Eligibility Requirements for completion of the program
A. Master’s course Students must complete the designated courses and meet the credit requirements in line withthe curriculum policy of this program and must meet the requirements for finishing theMaster’s course within their graduate schools.
 Doctoral Qualification Examination
In this program, at the end of the second year, a Doctoral Qualification Examination (QE) will
be conducted as a mid-term evaluation.
1. Students have to submit a report in English on fundamental knowledge and skills in
Medical Science, Human Health Sciences, Engineering, Pharmacology and each specialty
and related field.
2. Students have to submit a research plan (which is to be prepared during the first andsecond year “Pre-research” period) related to their thesis research (which will be
conducted during the third to fifth year) for Doctoral dissertation.
3. Students have to present their research plan orally. Results will be evaluated by four
members of the QE Committee: two mentors of the program-specific staff; one professorof the program (teaching advisor) and another professor of the program.
4. Skills in English debate will be evaluated.
Based on  fulfillment of eligibility requirement, and  result of QE, the Committee will
make a decision on completion of Master’s degree of the program.
Any students who do not meet the above requirements must take an extra year to improve any
insufficient knowledge. If the research plan is determined to be flawed or not promising,
re-submission will be required. In that case, mentors will give necessary support.
B. Doctoral course
The examination for the Doctoral degree will be started upon students’ request, then it will becommissioned by the Professors’ faculty meeting of their affiliated Graduate Schools, and a board
review of the program will be conducted. During the procedure, native English-speaking staff oruniversity researchers will carefully evaluate the students’ English debate skills. If approvable,
the all-campus steering committee of the Program for Leading Graduate Schools will certify
completion. The results will be reported to the Professors’ faculty meeting of their affiliated14affiliated graduate schools.
(5) Academic degrees
A. Master’s course
A Master’s degree from each affiliated graduate school will be awarded to students who havefinished a Master’s course.
B. Doctoral course
Different between affiliated graduate schools as follows:
After each Doctoral statement (Medical Science, Human Health Sciences, Medicine,
Engineering, Pharmacology), completion of the “Training program of leaders for integrated
medical system for fruitful healthy-longevity society” will be certified.
(6) Diploma policy
In order to support and build up new concepts and political directions that help people to live afruitful life in old age, students with a non-medical background of medical science, engineering,or pharmaceutical science majors need to gain fundamental medical knowledge. In addition tothese technical and research skills, the students are required to acquire English proficiency as wellas the ability to debate in order to be able to play an active part in international research centers,companies and public organizations. The students are also required to be able to see present andfuture problems of a globally unprecedented aging society and to be able to use their skills andknowledge in cooperation with people from different backgrounds to solve these problems. The
education at LIMS vigorously trains students to become strong leaders who can shape the successof the aging society not only in Japan and Asian countries, but also all over the world.
(7) Portfolio
Each student needs to make a portfolio in which self-evaluation of classes, grades, academic
achievements, and evaluation by faculty will be noted. It must be updated regularly for inspection
by the teaching advisors and mentors. This portfolio will be used as a part of the evaluation for
promotion and the continuation of the student’s allowance.

4. Financial Support for program students
Financial support will be given to program students to encourage them to concentrate on classes andthesis research of the Program for Leading Graduate Schools.
Allowance incentives
Outstanding students who satisfy all of the eligibility requirements for recipients will be supported witha monthly allowance. The amount and continuation of allowances depends on the performance during
the selection procedure, and academic achievements evaluated by teachers and mentors at the end ofeach academic year.
The names of recipients will be posted at the campus and on the LIMS homepage.

[Eligibility requirements for recipients]15[1] Those who are successful applicants of this program.
[2] Those who are not receiving financial support from any scholarship or stipend (except for atuition waiver by Kyoto University). However, students who decline financial support from thisprogram will be able to take training in this program while receiving other scholarships, such as ascholarship from the Japanese government.
[3] Those who are not receiving or expecting to receive any remuneration including wages forpart-time work, with the exception of honorarium payments relating to the publication orpresentation of research results, copyright fees or royalties, or a Teaching Assistant (TA) or
Research Assistant (RA) allowance which is deemed essential to the program (up to 5 hours perweek).
[4] Those who have been enrolled for no more than five academic years (not including any period of
temporary absence) in a graduate school at Kyoto University.
[5] Those who are deemed to have achieved excellence based on their grades and scores in thisprogram.
[6] Those who agree to continuously pursue their education and research during the 5-year period of
this program.
[Loss of eligibility for financial support]
Recipients who fall in one of the following categories will lose their eligibility for financial support:(1) Those who lose one of [1] to [6] requirements of [Eligibility requirements for recipients] above.
(2) Those who submit a letter of declination of the financial support from this program, and the letteris accepted.
(3) Those who submitted false statements in the application documents of this program.
(4) Those who stop studying, quit university or are expelled from university.
(5) Those who are subjected to disciplinary action, following the Kyoto University General Rules.

16䝥䝻䜾䝷䝮ᢸᙜ⪅୍ぴプログラム担当者一覧
Ặ䚷䚷ྡ
㻝

䜴䜶䝰䝖

䝅䞁䝆

㻞

䝣䜽䝲䝬䚷䚷䝠䝕䝘䜸

ୖᮏ䚷ఙ஧
⚟ᒣ䚷⚽┤

ᡤ䚷䚷ᒓ

ᑓᨷ➼

⫋䚷䚷ྡ

ഛ䚷䚷⪃

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝥䝻䜾䝷䝮㈐௵⪅䞉་Ꮫ◊✲⛉㛗

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝥䝻䜾䝷䝮䝁䞊䝕䜱䝛䞊䝍䞊䞉㻸㻵㻹㻿䝴䝙䝑䝖㛗

䝎䜲

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝝䜼䝽䝷

䝬䝃䝖䝅

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝃䜲䝖䜴

䝭䝏䝜䝸

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻢

䝬䝒䝎

䝭䝏䝴䜻

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻣

䝝䜺

䝠䝻䝜䝸

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䜲䝽䝍

䝋䜴

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝜䝎

䝬䝁䝖

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻟
㻠
㻡

㻤
㻥

䝽䝍䝘䝧

䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅

Ώ㑓䚷኱
ⴗཎ䚷ṇᩄ
ᩪ⸨䚷㏻⣖
ᯇ⏣䚷㐨⾜

⩚㈡䚷༤඾
ᒾ⏣䚷᝿
㔝⏣䚷ு
䝅䝜䝝䝷

䝍䜹䝅

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䜹䝛䝁

䝍䜿䝅

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䜹䝽䝜

䜿䞁䝆

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻟

䜸䜸䝰䝸

䝝䝹䝜䝸

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻠

䜻䝮䝷

䝍䜿䝅

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻜
㻝㻝
㻝㻞

⠛ཎ䚷㝯ྖ
㔠Ꮚ䚷ṊႹ
Ἑ㔝䚷᠇஧
኱᳃䚷἞⣖
ᮌᮧ䚷๛

䝭䝅䝬

䝭䝏䜰䜻

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻢

䝠䝷䜸䜹

䝬䝃䝠䝻

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻣

䝖䜺䝅䚷䚷䚷䚷䜹䜸䝸

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻝㻤

䜲䝏 䝲䝬

䝃䝖䝅

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝃䜹䜲

䝶䝅䝝䝹

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝖䜲

䝬䝃䜹䝈

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝁䝙䝅

䜲䜽䜸

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䜸䝃䝮

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝃䜹䝍

䝸䝳䜴䝌䜴

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝇䝈䜻

䝅䝀䝠䝁

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝶䝅䝮䝷

䝘䜺䝠䝃

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻞㻢

䜲䝖䜴

䝆䝳䜲䝏

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻞㻣

䝬䝒䝎

䝅䝳䜴䜲䝏

㻝㻡

㻝㻥
㻞㻜
㻞㻝
㻞㻞
㻞㻟
㻞㻠
㻞㻡

୕ᔱ䚷⌮᫭
ᖹᒸ䚷┾ᐶ
ᐩᶔ䚷䛛䛚䜚
୍ᒣ䚷ᬛ

ᆏ஭䚷⩏἞
ᡞ஭䚷㞞࿴
ᑠす䚷㑳⏕
䜸䜺䝽

ᑠᕝ䚷ಟ

ᆏ⏣䚷㝯㐀
㕥ᮌ䚷ⱱᙪ
ྜྷᮧ䚷㛗ஂ
ఀ⸨䚷ኖ୍

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻞㻤

䝣䝆䝍

䝆䝳䞁

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻞㻥

䝍䜹䝝䝅

䝸䝵䜴䝇䜿

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

䝭䝲䝰䝖

䝇䝇䝮

་Ꮫ◊✲⛉

་Ꮫ

ᩍᤵ

㻟㻜
㻟㻝
㻟㻞
㻟㻟
㻟㻠
㻟㻡
㻟㻢
㻟㻣

ᯇ⏣䚷⚽୍
⸨⏣䚷₶

㧗ᶫ䚷Ⰻ㍜
ᐑᮏ䚷ா

䝁䝇䜼

䝅䞁䝆

་Ꮫ◊✲⛉

♫఍೺ᗣ་Ꮫ⣔ᩍᤵ䝍䜲䝷་Ꮫ㒊㝃ᒓ⑓㝔㍺⾑⣽⬊἞⒪㒊

ᩍᤵ

䜻䝭䝜䝸

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

ᑠᮡ䚷┾ྖ
䝬䜶䜹䝽

๓ᕝ䚷ᖹ

䝩䝋䝎

⣽⏣䚷බ๎
䜹䝒䝷 䝖䝅䜻

་Ꮫ◊✲⛉ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䜻䝜䝅䝍

䜰䝲䜶

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䜰䝎䝏

䝋䜴䜲䝏

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔ᩍᤵ䝅䜲䝘䚷䚷䚷䝒䝶䝅་Ꮫ◊✲⛉ே㛫೺ᗣ⛉Ꮫ⣔ᩍᤵ་Ꮫ◊✲⛉ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

᱇䚷ᩄᶞ

ᮌୗ䚷ᙬᰤ
㊊❧䚷ኋ୍
᳝ྡ䚷Ẏ

䝇䜼䝰䝖

䝘䜸䝌䜴

䜽䝻䜻

䝠䝻䝅

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䜲䝏䝝䝅

䝜䝸䜰䜻

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䝣䝍䜻

䝖䝅䝁

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䜰䝷䜲

䝠䝕䝜䝸

་Ꮫ◊✲⛉

ே㛫೺ᗣ⛉Ꮫ⣔

ᩍᤵ

䝁䝔䝷

䝠䝕䝖䝅

ᕤᏛ◊✲⛉

䝬䜲䜽䝻䜶䞁䝆䝙䜰䝸䞁䜾

ᩍᤵ

㻠㻠

䜻䝮䝷

䝅䝳䞁䝃䜽

ᕤᏛ◊✲⛉

ᮦᩱ໬Ꮫ

ᩍᤵ

㻠㻡

䝅䝷䜹䝽

䝬䝃䝠䝻

ᕤᏛ◊✲⛉

ศᏊᕤᏛ

ᩍᤵ

㻠㻢

䜰䜻䝶䝅

䜹䝈䝘䝸

ᕤᏛ◊✲⛉

㧗ศᏊ໬Ꮫ

ᩍᤵ

ᕤᏛ◊✲⛉

ྜᡂ䞉⏕≀໬Ꮫ

ᩍᤵ

㻟㻤
㻟㻥
㻠㻜
㻠㻝
㻠㻞
㻠㻟

㻠㻣

ᮡᮏ䚷┤୕
㯮ᮌ䚷⿱ኈ
ᕷᶫ䚷๎᫂

஧ᮌ䚷ῄᏊ
Ⲩ஭䚷⚽඾
ᑠᑎ䚷⚽ಇ
ᮌᮧ䚷ಇస
ⓑᕝ䚷ᫀᏹ

⛅ྜྷ䚷୍ᡂ
䝰䝸䚷䚷䚷䝲䝇䜸

᳃䚷Ὀ⏕

㝃ᒓ⑓㝔㛗

ᖹᡂ㻞㻢ᖺ㻝㻞᭶䜎䛷17䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅

Ặ䚷䚷ྡ
㻠㻤

䝝䝬䝏

䜲䝍䝹

ᡤ䚷䚷ᒓ

ᑓᨷ➼

⫋䚷䚷ྡ

ᕤᏛ◊✲⛉

ྜᡂ䞉⏕≀໬Ꮫ

ᩍᤵ

㻠㻥

䝘䜹䝧

䜹䝈䝶䝅

ᕤᏛ◊✲⛉

ᶵᲔ⌮ᕤᏛ

ᩍᤵ

㻡㻜

䜸䜸䝅䝬

䝬䝃䝠䝻

ᕤᏛ◊✲⛉

໬ᏛᕤᏛ

ᩍᤵ

㻡㻝

䜹䞁䝜䚷䚷䚷䚷䜲䜽䜸

ᕤᏛ◊✲⛉

ཎᏊ᰾ᕤᏛ

ᩍᤵ

㻡㻞

䜸䜸䜶䚷䚷䚷䚷䝁䜴䜲䝏ᕤᏛ◊✲⛉≀㉁䜶䝛䝹䜼䞊໬Ꮫ

ᩍᤵ

℈ᆅ䚷᱁

୰㒊䚷୺ᩗ

኱ᔱ䚷ṇ⿱
⚄㔝䚷㑳ኵ

኱Ụ䚷ᾈ୍

㻡㻟

䝁䞁䝗䜴

䝔䝹䝴䜻

Ꮫ㝿⼥ྜᩍ⫱◊✲᥎㐍䝉䞁䝍䞊ඛ➃་ᕤᏛ◊✲䝴䝙䝑䝖

ᩍᤵ

㻡㻠

䝃䝆

䝠䝕䜸

㏆⸨䚷㍤ᖾ

⸆Ꮫ◊✲⛉

⸆Ꮫ

ᩍᤵ

䝭䝒䝹

⸆Ꮫ◊✲⛉

⸆Ꮫ

ᩍᤵ

䜹䜿䝲䚷䚷䚷䝠䝕䜰䜻⸆Ꮫ◊✲⛉་⸆๰ᡂ᝟ሗ⛉Ꮫ

ᩍᤵ

䝘䜹䝲䝬

䜹䝈䝠䝃

⸆Ꮫ◊✲⛉

⸆⛉Ꮫ

ᩍᤵ

䜹䝖䜴

䝠䝻䜰䜻

⸆Ꮫ◊✲⛉

⸆⛉Ꮫ

䝺䜲

ⓑ┱䝉䞁䝍䞊

≉ᐃ෸ᩍᤵ

䜲䝽䝍

䝠䝻䜸

෌⏕་⛉Ꮫ◊✲ᡤ

ᩍᤵ

䝍䝞䝍

䝲䝇䝠䝁

෌⏕་⛉Ꮫ◊✲ᡤᩍᤵ෌⏕་⛉Ꮫ◊✲ᡤᩍᤵ䝍䜲䝆෌⏕་⛉Ꮫ◊✲ᡤᩍᤵ䝠䝷䜻 䝴䜴䝆

෌⏕་⛉Ꮫ◊✲ᡤ

ᩍᤵ

㻢㻡

䝉 䝝䝷

䜰䝒䝁

෌⏕་⛉Ꮫ◊✲ᡤᩍᤵ㻢㻢䝘䜺䝃䝽 䝍䜹 䝅෌⏕་⛉Ꮫ◊✲ᡤᩍᤵ෌⏕་⛉Ꮫ◊✲ᡤᩍᤵᩘ⌮ゎᯒ◊✲ᡤᩍᤵᩘ⌮ゎᯒ◊✲ᡤ

ᩍᤵ

㻡㻡
㻡㻢

బ἞䚷ⱥ㑻
䝝䝅䝎

ᶫ⏣䚷඘

᥃㇂䚷⚽᫛

㻡㻣

୰ᒣ䚷࿴ஂ

㻡㻤

ຍ⸨䚷༤❶

㻡㻥
㻢㻜
㻢㻝
㻢㻞
㻢㻟
㻢㻠

䝂䝖䜴

ᚋ⸨䚷ບ

ᒾ⏣䚷༤ኵ
⏣⏿䚷Ὀᙪ
䝖䜾䝏

䝎

䝆䝳䞁䝲

ᡞཱྀ⏣䚷῟ஓ
䜰䝎䝏

Ᏻ㐩䚷Ὀ἞
㛤䚷♸ྖ

℩ཎ䚷῟Ꮚ

㛗⃝䚷ୣྖ

㻢㻣

䜹䝽䝰䝖

㻢㻤

䝰䝸

㻢㻥

䜸䜹䝰䝖

㻣㻜

䝠䝻䝅

Ἑᮏ䚷ᏹ
䝅䝀䝣䝭

᳃䚷㔜ᩥ
䝠䝃䝅

ᒸᮏ䚷ஂ

䝲䝬䝎

䝭䝏䜸

ᒣ⏣䚷㐨ኵ

㻣㻝

䝔䝷䝙䝅

䝴䝍䜹

㻣㻞

䜲䝅䜲䚷䚷䚷䜹䝶䝁ᑎす䚷㇏▼஭䚷ຍ௦Ꮚ

ᩘ⌮ゎᯒ◊✲ᡤഛ䚷䚷⪃ᩍᤵ෌⏕་⛉Ꮫ◊✲ᡤ㛗

ᩍᤵ

་Ꮫ◊✲⛉

䛂་Ꮫ㡿ᇦ䛃⏘Ꮫ㐃ᦠ᥎㐍ᶵᵓ≉௵ᩍᤵᏛ㝿⼥ྜᩍ⫱◊✲᥎㐍䝉䞁䝍䞊೺ᗣ㛗ᑑ♫఍䛾⥲ྜ་⒪㛤Ⓨ䝴䝙䝑䝖≉ᐃᩍᤵ

Program Professors

Program Professors
Name

18

(As of March 31, 2015)

Graduate School etc.

Devision

Position1

Shinji Uemoto

Graduate School of Medicine

Medicine

Professor

2

Hidenao Fukuyama

Graduate School of Medicine

Medicine

Professor

3

Dai Watanabe

Graduate School of Medicine

Medicine

Professor

4

Masatoshi Hagiwara

Graduate School of Medicine

Medicine

Professor

5

Mitinori Saitou

Graduate School of Medicine

Medicine

Professor

6

Michiyuki Matsuda

Graduate School of Medicine

Medicine

Professor

7

Hironori Haga

Graduate School of Medicine

Medicine

Professor

8

So Iwata

Graduate School of Medicine

Medicine

Professor

9

Makoto Noda

Graduate School of Medicine

Medicine

Professor

10 Takashi Shinohara

Graduate School of Medicine

Medicine

Professor

11 Takeshi Kaneko

Graduate School of Medicine

Medicine

Professor

12 Kenji Kawano

Graduate School of Medicine

Medicine

Professor

13 Harunori Ohmori

Graduate School of Medicine

Medicine

Professor

14 Takeshi Kimura

Graduate School of Medicine

Medicine

Professor

15 Michiaki Mishima

Graduate School of Medicine

Medicine

Professor

16 Masahiro Hiraoka

Graduate School of Medicine

Medicine

Professor

17 Kaori Togashi

Graduate School of Medicine

Medicine

Professor

18 Satoshi Ichiyama

Graduate School of Medicine

Medicine

Professor

19 Yoshiharu Sakai

Graduate School of Medicine

Medicine

Professor

20 Masakazu Toi

Graduate School of Medicine

Medicine

Professor

21 Ikuo Konishi

Graduate School of Medicine

Medicine

Professor

22 Osamu Ogawa

Graduate School of Medicine

Medicine

Professor

Notes

Program Director,
Dean of Graduate School of
Medicine
Program Coordinator,
Director of LIMS Unit

Director of Kyoto University
Hospital15 Michiaki Mishima

Graduate School of Medicine

Medicine

Professor

16 Masahiro Hiraoka

Graduate School of Medicine

Medicine

Professor

17 Kaori Togashi

Graduate School of Medicine

Medicine

Professor

18 Satoshi Ichiyama

Graduate School of Medicine

Medicine

Professor

19 Yoshiharu Sakai

Graduate School of Medicine

Medicine

Professor

20 Masakazu
Toi
Name

Graduate
Schoolof Medicine
Graduate
Schooletc.

Medicine
Devision

Professor
Position

23 Ikuo
Ryuzo
Sakata21
Konishi

Graduate School of Medicine

Medicine

Professor

24 Osamu
Shigehiko
Suzuki
22
Ogawa
Name

Graduate
Schoolof Medicine
Graduate
Schooletc.

Medicine
Devision

Professor
Position

23 Nagahisa
Ryuzo Sakata
25
Yoshimura

Graduate School of Medicine

Medicine

Professor

24 Juichi
Shigehiko26
Ito Suzuki

Graduate School of Medicine

Medicine

Professor

25 Shuichi
Nagahisa
Yoshimura
27
MatsudaGraduate School of Medicine

Medicine

Professor

26 JunJuichiIto
28
FujitaGraduate School of Medicine

Medicine

Professor

27 Ryosuke
Shuichi Matsuda
29
Takahashi

Graduate School of Medicine

Medicine

Professor

28 Susumu
Jun FujitaMiyamoto
30

Graduate School of Medicine

Medicine

Professor

29 Shinji
Ryosuke
Takahashi
31
Kosugi

Graduate School of Medicine

School Medicineof Public HealthProfessor

30 Taira
SusumuMiyamoto
32
Maekawa

Graduate
School ofHospital
Medicine
Kyoto University

Medicine
Transfusion Medicine
and Cell Therapy

Professor

31 Kiminori
Shinji Kosugi
33
HosodaGraduate School of Medicine

School Healthof Public
HealthHuman
Sciences

Professor

32
Maekawa
34 Taira
Toshiki
KatsuraKyoto University
Graduate
School ofHospital
Medicine

Transfusion
Medicine
Cell Therapy
Human
Healthand
Sciences

Professor

33
Hosoda35 Kiminori
Ayae Kinoshita

Graduate School of Medicine

Human Health Sciences

Professor

34
36 Toshiki
Souichi Katsura
Adachi

Graduate School of Medicine

Human Health Sciences

Professor

35
Kinoshita
37 AyaeTsuyoshi
ShiinaGraduate School of Medicine

Human Health Sciences

Professor

36
Adachi38 Souichi
Naozo Sugimoto

Graduate School of Medicine

Human Health Sciences

Professor

37
Shiina39 Tsuyoshi
Hiroshi Kuroki

Graduate School of Medicine

Human Health Sciences

Professor

38
40 Naozo
NoriakiSugimoto
Ichihashi

Graduate School of Medicine

Human Health Sciences

Professor

39
41 Hiroshi
ToshikoKuroki
Futaki

Graduate School of Medicine

Human Health Sciences

Professor

40
42 Noriaki
HidenoriIchihashi
Arai

Graduate School of Medicine

Human Health Sciences

Professor

41 Hidetoshi
Toshiko Futaki
43
KoteraGraduateSchool
SchoolofofEngineering
Medicine
Graduate

Human
Sciences
MicroHealthEngineering

Professor

42 Shunsaku
Hidenori Arai
44
KimuraGraduateSchool
SchoolofofEngineering
Medicine
Graduate

Human
HealthSciences
Material
Chemistry

Professor

43 Masahiro
Hidetoshi Shirakawa
Kotera45

Graduate School of Engineering

Micro Engineering
Molecular
Engineering

Professor

44 Kazunari
ShunsakuAkiyoshi
Kimura46

Graduate School of Engineering

Material Chemistry
Polymer

Professor

45 Yasuo
Masahiro
Shirakawa
47
Mori

Graduate School of Engineering

Molecular
Engineering
Synthetic
Chemistry andBiological Chemistry

Professor

46 Itaru
Kazunari
Akiyoshi48
Hamachi

Graduate School of Engineering

Chemistry
Synthetic Polymer
Chemistry andBiological Chemistry

Professor

47 Kazuyoshi
Yasuo MoriNakabe
49

Graduate School of Engineering

Synthetic
Chemistry
and Biological
Chemistry
MechanicalEngineeringand Science

Professor

48 Masahiro
Itaru Hamachi
50
OhshimaGraduate School of Engineering

Synthetic
Chemistry andBiological Chemistry
ChemicalEngineering

Professor

49 IkuoKazuyoshi
51
KannoNakabe

Graduate School of Engineering

MechanicalEngineeringand Science
NuclearEngineering

Professor

50 Kouichi
Masahiro
Ohshima52
Ohe

Graduate School of Engineering

Engineering
EnergyChemicaland Hydrocarbon
Chemistry

Professor

51 Teruyuki
Ikuo Kanno
53
Kondo

Center for the Promotion of Interdisciplinary
Graduate
School of Engineering
Education and Research

Advanced Biomedical Engineering Research
Nuclear Engineering
Unit

Professor

52 Hideo
KouichiSaji
Ohe
54

Graduate
Schoolof Engineering
Graduate
Schoolof Pharmaceutical
Sciences

Energy Biomedicaland Hydrocarbon
Chemistry
Sciences

Professor

53 Mitsuru
TeruyukiHashida
Kondo
55

Center for the Promotion of Interdisciplinary
Graduate Schoolof Pharmaceutical
Education
and Research Sciences

Advanced Biomedical Engineering Research
Biomedical
UnitSciences

Professor

54 Hideaki
Hideo Saji
56
KakeyaGraduate School of Pharmaceutical Sciences

Biomedical
Sciences
Bioinformatics
and Chemical
Genomics

Professor

55 Kazuhisa
Mitsuru Hashida
57
Nakayama

Graduate School of Pharmaceutical Sciences

Biomedical Sciences
Pharmaceutical
Sciences

Professor

56 Hiroaki
Hideaki Kato
Kakeya58

Graduate School of Pharmaceutical Sciences

Bioinformatics
and Chemical
Genomics
Pharmaceutical
Sciences

Professor

57 ReiKazuhisa
59
Goto Nakayama

Graduate The
SchoolHakubi
of Pharmaceutical
Project Sciences

Pharmaceutical Sciences

Program-SpecificProfessor
Associate Professor

58 Hiroo
HiroakiIwata
Kato60

Graduateof Pharmaceutical
Sciences
InstituteSchool
for Frontier
Medical Sciences

Pharmaceutical Sciences

Professor

59 Yasuhiko
Rei Goto Tabata
61

HakubiMedical
Project
InstituteThefor Frontier
Sciences

Program-SpecificProfessor
Associate
Professor

60
Hiroo Iwata
Toguchida
62 JunyaInstitute for Frontier Medical Sciences

Professor

61 TaijiYasuhikoTabata63
Adachi

Institute for Frontier Medical Sciences

Professor

62 Yuji
Junya
Toguchida64
Hiraki

Institute for Frontier Medical Sciences

Professor

63 Atsuko
Taiji Adachi
65
SeharaInstitute for Frontier Medical Sciences

Professor

64
Hiraki66 YujiTakashiNagasawa

Institute for Frontier Medical Sciences

Professor

65 Hiroshi
Atsuko Sehara
67
Kawamoto

Institute for Frontier Medical Sciences

Professor

66 Shigefumi
Takashi Nagasawa
68
Mori

InstituteInstitutefor Frontier
Medical Sciences
Research
for Mathematical
Sciences

Professor

67 Hisashi
Hiroshi Kawamoto
69
OkamotoInstituteInstitutefor Frontier
Medical Sciences
Research
for Mathematical
Sciences

Professor

68 Michio
Shigefumi
Mori
70
YamadaResearch Institute for Mathematical Sciences

69 YutakaHisashi Teranishi
Okamoto71

Research
InstituteSchoolfor Mathematical
Graduateof MedicineSciences

70 Kayoko
Michio Yamada
72
Ishii

Center forInstitutethe Promotionof Interdisciplinary
Research
for Mathematical
Sciences
Education and Research

71 Yutaka Teranishi
72 Kayoko Ishii

Graduate School of Medicine
Center for the Promotion of Interdisciplinary
Education and Research

Hospital(As of March 31, 2015)

Notes(As of March 31, 2015)

Notes

Until December 2014

Until December 2014

Director of Institute for Frontier
Medical Sciences
Director of Institute for Frontier
Medical Sciences

Professor
Medical Science and Business Liaison
Organization

Specially Appointed
Professor
Professor

Research and Educational Unit of Leaders for
Integrated Medical System (LIMS)
Medical Science and Business Liaison
Organization

Program-SpecificProfessor
Professor
Specially Appointed
Professor

Research and Educational Unit of Leaders for
Integrated Medical System (LIMS)

Program-SpecificProfessor

19≉ᐃᩍဨ୍ぴ

特定教員一覧
≉ᐃᩍဨ୍ぴ
㻝
㻝
㻞
㻞
㻟
㻟
㻠
㻠
㻡
㻡
㻢
㻢
㻣
㻣
㻤
㻤
㻥
㻥
㻝㻜
㻝㻜
㻝㻝
㻝㻝
㻝㻞
㻝㻞
㻝㻟
㻝㻟
㻝㻠
㻝㻠
㻝㻡
㻝㻡
㻝㻢
㻝㻢
㻝㻣
㻝㻣
㻝㻤
㻝㻤
㻝㻥
㻝㻥
㻞㻜
㻞㻜
㻞㻝
㻞㻝
㻞㻞
㻞㻞
㻞㻟
㻞㻟

Ặ䚷䚷ྡ
䜲䝅䜲Ặ䚷䚷ྡ䜹䝶䝁▼஭䜲䝅䜲 䚷ຍ௦Ꮚ
䜹䝶䝁
▼஭
䚷ຍ௦Ꮚ
䜻䝮䝷
䝴䜴
ᮌᮧ
䜻䝮䝷 䚷♸
䝴䜴
ᮌᮧ
䝍䜹
䜸䝸 䚷♸
䜻䝵䜴䜲䝏
㧘
ᢡ䚷ᜤ୍
䝍䜹 䜸䝸
䜻䝵䜴䜲䝏
㧘䝙䝅ᢡ䚷ᜤ୍
䝭䝴䜻
す
䝙䝅䚷⨾ᖾ
䝭䝴䜻
す䚷⨾ᖾ
䝬䝒䝝䝅
䝬䝃䜸
ᯇᶫ
䝬䝒䝝䝅䚷┾⏕
䝬䝃䜸ᯇᶫ䝲䝬䝰䝖 䚷┾⏕䝁䜴䝆ᒣᮏ䝲䝬䝰䝖 䚷ᾈྖ
䝁䜴䝆
ᒣᮏ
䜸䜸
䜶 䚷ᾈྖ
䜿䞁䝆
኱
Ụ䚷㈼἞
䜸䜸䜶
䜿䞁䝆
኱Ụ䚷㈼἞
䜻䝜䝅䝍
䝍䜿䝠䝁
ᮌୗ
䜻䝜䝅䝍 䚷Ṋᙪ
䝍䜿䝠䝁
ᮌୗ䚷Ṋᙪ
䝍䜹䝝䝅
㻌㻌䝯䜲䝁
㧗ᶫ䚷䜑䛔Ꮚ
䝍䜹䝝䝅
䝁
㧗ᶫ
䚷䜑䛔Ꮚ
䝖䝭䝓䜹䚷䚷䚷䚷䝍䝻䜴ᐩሯ䚷ኴ㑻䝖䝭䝓䜹䚷䚷䚷䚷䝍䝻䜴ᐩሯ䚷ኴ㑻䝠䜺䝅䝰䝸䚷䚷䝜䝤䝴䜻ᮾ᳃䚷ಙᑵ䝠䜺䝅䝰䝸䚷䚷䝜䝤䝴䜻
ᮾ᳃䚷ಙᑵ
䝠䜾䝏
䝴䝸䝁
ᵽཱྀ䚷䜖䜚Ꮚ䝠䜾䝏䝁ᵽཱྀ䝬䝒䝎 䚷䜖䜚Ꮚ䝽䝁䝖ᯇ⏣䝬䝒䝎 䚷࿴㑻
䝽䝁䝖
ᯇ⏣䚷࿴㑻
䜲䝏䝮䝷
䜰䝒䝠䝁
ᕷᮧ
䜲䝏䝮䝷 䚷ᩔᙪ
䜰䝒䝠䝁
ᕷᮧ䚷ᩔᙪ
䜲䝘䝞
䝘䜸䝁
✄ሙ
䜲䝘䝞 䚷┤Ꮚ
䝘䜸䝁
✄ሙ䚷┤Ꮚ
䝁䞁䝗䜴
䜿䞁䝂
㏆⸨
䝁䞁䝗䜴 䚷೺࿃䜿䞁䝂㏆⸨
䝃䝖䜴 䚷೺࿃䝣䝭䝜䝸బ⸨䝃䝖䜴 䚷ᩥつ䝣䝭䝜䝸బ⸨䚷ᩥつ䝍䜻䝰䝖䚷䚷䚷䜰䜻⁪ᮏ䚷ᬗ䝍䜻䝰䝖䚷䚷䚷䜰䜻⁪ᮏ䚷ᬗ䝕䜱䞁䚷䚷䚷䝝䚷䚷䚷䝴䜱䚷䚷䚷䝔䜱䝕䜱䞁䚷䚷䚷䝝䚷䚷䚷䝴䜱䚷䚷䚷䝔䜱Dinh Ha Duy Thuy
Dinh䝖䝸䜲
Ha Duy䝭䜶 Thuy㫽஭䝖䝸䜲 䚷⨾Ụ䝭䜶㫽஭䝠䝷䜲 䚷⨾Ụ
䝲䝇䝝䝹
ᖹ஭䚷ᗣ἞
䝠䝷䜲
䝲䝇䝝䝹
ᖹ஭䚷ᗣ἞
䝝䝉䜺䝽䚷䚷䚷䚷䚷䝍䜽㛗㇂ᕝ䚷ᣅ䝝䝉䜺䝽䚷䚷䚷䚷䚷䝍䜽㛗㇂ᕝ䚷ᣅ䜽䝸䝇䝏䝱䞁䚷䚷䚷䚷䚷䜰䝹䝖䝬䞁䜽䝸䝇䝏䝱䞁䚷䚷䚷䚷䚷䜰䝹䝖䝬䞁
Christian
Altmann
Christian Altmann䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅
⫋䚷䚷ྡ
⫋䚷䚷ྡ
≉ᐃᩍᤵ䚷
≉ᐃᩍᤵ䚷

≉ᐃ෸ᩍᤵ
≉ᐃ෸ᩍᤵ

≉ᐃㅮᖌ
≉ᐃㅮᖌ

≉ᐃຓᩍ
≉ᐃຓᩍ

≉ᐃຓᩍ
≉ᐃຓᩍ
㻔ᖹᡂ㻞㻣ᖺ㻝᭶䜎䛷㻕་Ꮫ◊✲⛉≉ᐃ෸ᩍᤵ་Ꮫ◊✲⛉≉ᐃ෸ᩍᤵ㻔ᖹᡂ㻞㻣ᖺ㻝᭶䜎䛷㻕஦ົ⫋ဨ୍ぴ஦ົ⫋ဨ୍ぴ事務職員一覧

㻝
㻝
㻞
㻞
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㻢

20

Ặ䚷䚷ྡ
Ặ䚷䚷ྡ
䝖䜽䝷䚷䚷䚷䚷䚷䝔䝹䜸ᡞ಴䚷↷㞝䝖䜽䝷䚷䚷䚷䚷䚷䝔䝹䜸ᡞ಴䚷↷㞝䝜䜼䚷䚷䚷䚷䚷䚷䝶䝅䝬䝃㔝ᮌ䚷ῄ඲䝜䜼䚷䚷䚷䚷䚷䚷䝶䝅䝬䝃
㔝ᮌ䚷ῄ඲
䝬䝒䝎
䝁䝈䜶
ᯇ⏣䚷ᲈ
䝬䝒䝎
䝁䝈䜶
ᯇ⏣䚷ᲈ
䝃䜻䝰䝖䚷䚷䚷䝬䝸䝁ᓮᮏ䚷┿᲍Ꮚ
䝃䜻䝰䝖䚷䚷䚷䝬䝸䝁ᓮᮏ䚷┿᲍Ꮚ
䜴䝺䝅䝜 䝴䝸
Ꮀ㔝䚷཭㔛
䜴䝺䝅䝜
䝴䝸
Ꮀ㔝
䚷཭㔛
䜸䜸䝍䝙䚷䚷䚷䚷䝬䜻኱㇂䚷┿ᕼ䜸䜸䝍䝙䚷䚷䚷䚷䝬䜻኱㇂䚷┿ᕼ䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅䠄ᖹᡂ㻞㻣ᖺ㻟᭶㻟㻝᪥⌧ᅾ䠅
⫋䚷䚷ྡ
⫋䚷䚷ྡ
≉ᐃ⫋ဨ
㻔ᖹᡂ㻞㻣ᖺ㻝᭶䜎䛷㻕≉ᐃ⫋ဨ㻔ᖹᡂ㻞㻣ᖺ㻝᭶䜎䛷㻕
≉ᐃ⫋ဨ
≉ᐃ⫋ဨ
ᩍົ⿵బဨ
ᩍົ⿵బဨ
ὴ㐵⫋ဨ
ὴ㐵⫋ဨ
ὴ㐵⫋ဨ
ὴ㐵⫋ဨ
ὴ㐵⫋ဨ
ὴ㐵⫋ဨ

Program-Specific Staff
Program-Specific
Staff

Program-Specific Staff Position

Name
1(As of March 31, 2015)(As of March 31, 2015)

2
1

KayokoNameIshii
Yu Kimura
KayokoIshii

Program-SpecificPosition Professor

3
2

KyoichiTakaori
Yu Kimura

4
3

MiyukiTakaori
Nishi
Kyoichi

Program-Specific Associate Professor

5
4

Masao
Matsuhashi
Miyuki
Nishi

Program-Specific Associate Professor

6
5

Koji Yamamoto
Masao
Matsuhashi

7
6

Ohe
KojiKenji
Yamamoto

8
7

Takehiko
Kenji Kinoshita
Ohe

9
8

Meiko Takahashi
Takehiko
Kinoshita

109Taro Tomizuka
Meiko
Takahashi

Program-Specific Senior Lecturer

1110Nobuyuki
Higashimori
Taro Tomizuka

Program-Specific Senior Lecturer

12
11

YurikoHigashimori
HiguchiNobuyuki

13
12

WakotoMatsudaYuriko Higuchi

14
13

Atsuhiko
Ichimura
Wakoto Matsuda

15
14

Naoko Ichimura
Inaba
Atsuhiko

16
15

Kengo
Naoko Kondo
Inaba

17
16

Fuminori
Sato
Kengo Kondo

18
17

Aki Takimoto
Fuminori
Sato

19
18

Dinh
Duy Thuy
AkiHa
Takimoto

20
19

ToriiThuy
Dinh Mie
Ha Duy21
20

Yasuharu
Hirai
Mie Torii

21
22

Yasuharu
Hirai
Taku
Hasegawa

22
23

Taku Hasegawa
Christian Altmann

23

Christian Altmann

Program-Specific Professor

Program-Specific Assistant Professor
Program-Specific Assistant Professor

Program-Specific Assistant Professor(until January 2015)
Program-Specific Assistant Professor
Program-Specific Associate Professor(until January 2015)of Graduate School of Medicine
Program-Specific Associate Professorof Graduate School of Medicine

Administrative Staff

Name

Administrative Staff
Administrative
Staff Position(As of March 31, 2015)(As of March 31, 2015)

1

Teruo
TokuraName

1
2

Teruo Tokura
Yoshimasa
Nogi

Program-Specific Administrative Staff
Position2015)(until January
Program-Specific Administrative Staff
Program-Specific
Administrative
Staff(until January
2015)

3
2

Kozue Matsuda
Yoshimasa
Nogi

Assistant Administrative
StaffStaff
Program-Specific
Administrative

4
3

MarikoKozue Sakimoto
MatsudaAssistant Administrative Staff

5
4

Yuri Ureshino
MarikoSakimoto

Assistant Administrative Staff

6
5

Maki
Otani
Yuri
Ureshino

Assistant Administrative Staff

6

Maki Otani

Assistant Administrative Staff

21ᖹᡂ䠎䠒ᖺᗘ䚷LIMSᒚಟ⪅䠄M䠍䠅䞉ᣦᑟᩍᤵ䞉䝯䞁䝍䞊୍ぴ
平成26年度LIMS履修者（M１）
・指導教授・
メンター 一覧(ᖹᡂ27ᖺ3᭶31᪥⌧ᅾ)
◊
✲
⛉

1

2

3

ᑓ Ꮫ
ᨷ ᖺ

་ M
་
⛉
Ꮫ
1
Ꮫ

ᛶ
ู

Ặྡ

䝬䝒䝞䝷

䝠䝻䝴䜻

ᯇཎ䚷ᘯᖾ

ᡤᒓศ㔝

Aila Johanna䜰䝎䝏୰⏿䚷㱟ಇ䚷ᩍᤵᏳ㐩䚷Ὀ἞䚷ᩍᤵ

⁪ᮏ䚷ᬗ

㛗㇂ᕝ䚷ᣅ

⑌ᝈ෌⌧◊✲ศ㔝

iPS⣽⬊◊✲ᡤ⑌ᝈ෌⌧◊✲

෌⏕་⛉Ꮫ◊✲ᡤ䝞䜲䜸䝯䜹䝙䜽䝇◊✲
㡿ᇦ

≉ᐃຓᩍ
㸦Ⓨ⏕Ꮫ㸧

≉ᐃຓᩍ
䠄⚄⤒⏕⌮Ꮫ䠅㧗ḟ⬻⛉Ꮫㅮᗙ
ዪ㧗ḟ⬻ᙧែᏛ

䝆䞊

⸆ M
⸆
6
⛉
Ꮫ
1
Ꮫ

་
⸆
๰
ᡂ M
⸆
7
Ꮫ ᝟ 1
ሗ
⛉
Ꮫ

ศ
ᕤ Ꮚ M
8
Ꮫ ᕤ 1
Ꮫ

ศ
ᕤ Ꮚ M
9
Ꮫ ᕤ 1
Ꮫ

䝬䝒䝰䝖

䝖䝰䝁

ᯇᮏ䚷᭸Ꮚ

䝅䝜䝎䚷䚷䚷䚷䚷䚷䚷䝁䜴䜻

⠛⏣䚷᪸ᶞ

䝗䜴䝆䝵䜴

䜽䝭䝁

ᇽୖ䚷ஂ⨾Ꮚ

䜴䝜

䝬䝃䝖䝅

Ᏹ㔝䚷㞞ಇ

䝍䜿䝅䝍

䜲䝍䝹

➉ୗ䚷⮳

䝇䜶䝘䜺

䜹䝈䝬䝃

་⸆䛾つไ䛸೺ᗣಖ㝤ไᗘ䛾ほᮎỌ䚷࿴┿་⸆๰ᡂ᝟ሗ⛉Ꮫ䝅䝣䝖䝽䞊䜹䞊䛜䛛䛛䜚䜔䛩䛔⑓
ㅮᗙ
ዪ
Ẽ䛾◊✲
䝅䝇䝔䝮䝞䜲䜸䝻
䝆䞊ศ㔝䝃䜲䝖䜹䜲䞁䝛䝑䝖䝽䞊䜽䛾␗ᖖ⏕యศᏊᶵ⬟໬Ꮫ⏨䛻ᇶ䛵䛟⮬ᕫච␿⑌ᝈ䛾Ⓨ⑕ᶵㅮᗙᵓ䛾ண ཬ䜃᳨ド㻰㻺㻭䝯䝏䝹໬␗ᖖゎᯒ䛻䜘䜛Ⓨ⏕యศᏊᶵ⬟໬Ꮫ⏨䛜䜣䝸䝇䜽ホ౯䛸⏕ά⩦័䛸䛾ㅮᗙ┦㛵䛻㛵䛩䜛◊✲㧗ศᏊྜᡂㅮᗙ
⏨㔜ྜ໬Ꮫศ㔝

⏕యศᏊᐃ㔞䛾䛯䜑䛾᭷ᶵ䠉↓ᶵ䝝䜲䝤䝸䝑䝗ᮦᩱ䜢ᇶ┙䛸䛧䛯ᶵ⬟ᛶගᏛᮦᩱ䛾㛤Ⓨྜᡂ໬Ꮫㅮᗙ
⏨ᶵ⬟໬Ꮫศ㔝

䞉㧗㱋໬䛻క䛳䛶Ⓨ⑕䛩䜛⑌ᝈ䛾ᘬ䛝㔠䛸䚸䛭䜜䜢ᢚไ䛩䜛໬Ꮫ≀㉁䛻㛵䛩䜛ᩥ⊩ㄪᰝ䞉⏕యෆ䛻䛚䛡䜛⏕⌮άᛶ䜺䝇ศᏊ䛾ไᚚ䛸䛭䛾⮫ᗋᛂ⏝䛻㛵
䛩䜛◊✲

ྜ
ᡂ

ᕤ 䞉 M
11
⏕
Ꮫ ≀ 1

䜶䞁 䝜

䝠䝻䜻

㐲㔝䚷ᏹᏘ

໬
Ꮫ

ྜ
ᡂ
䞉 M
ᕤ
12
⏕
Ꮫ
≀ 1
໬
Ꮫ

䝙䝅䝍䝙

䝜䝤䝠䝁

す㇂䚷ᬸᙪ

ഛ䜢ホ౯䛩䜛䛣䛸䜈䛾㈉⊩໬Ꮫ◊✲ᡤ⏕యᶵ⬟໬Ꮫ◊✲ ᫬㛫⏕≀Ꮫ䛛䜙䜏䛯ຍ㱋䛻క䛖⏨䝞䜲䜸䝸䝈䝮䛾ኚ໬䛸⑌ᝈⓎ⑕䞉⣔἞⒪䛻㛵䛩䜛◊✲⏕యᶵ⬟タィ໬Ꮫ

Ꮫ

䜰䜻

䝝䝉䜺䝽

䝍䜿䝎䚷䚷䚷䚷䚷䚷㻌㻌㻌䝅䝳䞁䜲䝏䝠䝷䜸䜹䚷䚷䚷䚷䚷䚷䝬䝃䝠䝻䜻䝮䝷Ṋ⏣䚷ಇ୍䚷ᩍᤵᖹᒸ䚷┾ᐶ䚷ᩍᤵ

ᮌᮧ䚷♸

బ⸨䚷ᩥつ

་Ꮫ◊✲⛉
ᨺᑕ⥺㑇ఏᏛ་Ꮫ◊✲⛉ᨺᑕ⥺⭘⒆Ꮫ䞉⏬ീᛂ
⏝἞⒪Ꮫ

≉ᐃ෸ᩍᤵ
䠄㧗ศᏊ໬Ꮫ䠅≉ᐃຓᩍ
㸦Ⓨ⏕⏕≀Ꮫ࣭
ศᏊ⏕≀Ꮫ㸧

䝴䜴

䝃䝖䜴

䝍䜽

䝣䝭䝜䝸

䜹䝛䝁䚷䚷䚷䚷䚷䚷䚷䚷䝍䜿䝅䚷䝦䜲䜿䚷䚷䚷䚷䚷䚷䚷䝖䝅䜸㔠Ꮚ䚷ṊႹ䚷ᩍᤵᖹᐙ䚷ಇ⏨䚷ᩍᤵᵽཱྀ䚷䜖䜚Ꮚ

Dinh Ha Duy Thuy་Ꮫ◊✲⛉㧗ḟ⬻ᙧែᏛ

་Ꮫ◊✲⛉Ⓨ㐩ᑠඣ⛉Ꮫ

≉ᐃㅮᖌ㸦⏕≀⸆๣Ꮫ㸧≉ᐃຓᩍ䠄⬻ᶵ⬟䜲䝯䞊䝆䞁䜾䠅䝠䜾䝏䚷䚷䚷䚷䚷䚷䝴䝸䝁䝕䜱䞁䚷㻌㻌㻌㻌㻌㻌㻌㻌㻌䝝䚷㻌㻌㻌㻌㻌㻌䝴䜱䚷㻌㻌㻌㻌㻌㻌㻌㻌㻌䝔䜱⚄⤒䜰䞊䜻䝔䜽䝏䝱䛾ຍ㱋ኚ໬་⒪᳨ᰝᒎ㛤Ꮫㅮ෌⏕་⒪䛾ᐇ⌧䛻䛚䛡䜛་⒪೔ዪ ᗙ⌮ၥ㢟䞉ㄢ㢟䛻䛴䛔䛶ᇶ♏᳨ᰝᒎ㛤Ꮫ

㧗

ᕤ ศ M
10
Ꮚ
Ꮫ ໬ 1

22

Ṛஸ⋡䞉⑌⑓⋡䛾పୗ䜢䜑䛦䛧䛯䛜䜣䛾ຠᯝⓗ἞⒪䛾☜❧䛚䜘䜃䛜䜣἞⒪䛻䛚䛡䜛໬Ꮫ⒪ἲ䛸ᨺᑕ⥺⒪ἲ䛾㔜せᛶ䛾ホ౯

䝍䜲䝆

䝍䜻䝰䝖

䝯䞁䝍䞊
⫋ྡ䚸䠄ᑓ㛛ศ㔝䠅䝘䜹䝝䝍䚷䚷䚷䚷䚷㻌䝍䝒䝖䝅⏕యᶵ⬟໬Ꮫ◊✲་ M MBENZA MBAMBI
Ⅼ䛻䛚䛡䜛᪥ᮏ䛸䛾ẚ㍑䜢㏻䛧
་
⛉
⏨ ⣔
Ꮫ
1
䛶䚸䝁䞁䝂䛻䛚䛡䜛་⒪ᨻ⟇䛾୙Ꮫ
NAASSON䜿䝭䜹䝹䝞䜲䜸䝻

ே
㛫
೺ M
་
5
ᗣ
Ꮫ
1
⛉
Ꮫ
⣔

LIMSᣦᑟᩍᤵ

iPS⣽⬊◊✲ᡤ໬Ꮫ◊✲ᡤ
4◊✲⛉ᣦᑟᩍᤵ⏨ ⮫ᗋᛂ⏝◊✲㒊㛛 ⓑ⾑⑓䛻䛚䛡䜛⌧ᅾ䛾἞⒪ἲ

་ M㑇ఏ་Ꮫㅮᗙ
་⛉⏨Ꮫ
1 SAHA Liton Kumarᨺᑕ⥺㑇ఏᏛ
Ꮫ

་ M
་
⛉
Ꮫ
1
Ꮫ

㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䝯䞁䝍䞊⫋ྡ䚸䠄ᑓ㛛ศ㔝䠅ྜᡂ໬Ꮫㅮᗙ
䞉ගᛂ⟅ᛶศᏊ䛾⏕య䜈䛾ᛂ⏝⏨≀⌮᭷ᶵ໬Ꮫศ㔝 䞉⏕య୰䛷䛾༠ྠⓗ⤌⧊໬ᣲື䜴䜶䝇䜼䚷䚷䚷䚷䚷䚷䝰䝖䝘䝸䚷䝔䝷䝙䝅䚷䚷䚷䚷䝴䝍䜹ୖᮡ䚷ᚿᡂ䚷ᩍᤵᑎす䚷㇏䚷ᩍᤵ

໬Ꮫ◊✲ᡤ䜿䝭䜹䝹䝞䜲䜸䝻䝆䞊་Ꮫ◊✲⛉䛂་Ꮫ㡿ᇦ䛃⏘Ꮫ㐃ᦠ᥎㐍ᶵᵓ䝬䝒䝎䚷䚷䚷䚷䚷䚷䚷䝽䝁䝖䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷䚷
䝠䝷䜲
䝲䝇䝝䝹

ᯇ⏣䚷࿴㑻

ᖹ஭䚷ᗣ἞

≉ᐃㅮᖌ
㸦⚄⤒ゎ๗Ꮫ࣭
ゎ๗Ꮫ୍⯡㸧

≉ᐃຓᩍ䠄⚄⤒⏕⌮Ꮫ䠅䝃䜲䝖䜴䚷䚷䚷䚷䚷䜽䝙䜰䜻䚷䝬䜶䜹䝽䚷䚷䚷䚷䚷䚷䝍䜲䝷䝬䝒䝝䝅㰻⸨䚷㑥᫂䚷ᩍᤵ๓ᕝ䚷ᖹ䚷ᩍᤵ

ᯇᶫ䚷┾⏕

㛗㇂ᕝ䚷ᣅ

་Ꮫ◊✲⛉
ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷᇶ♏᳨ᰝᒎ㛤Ꮫ་Ꮫ㒊㝃ᒓ⑓㝔㍺⾑⣽⬊἞⒪㒊≉ᐃ෸ᩍᤵ㸦⮫ᗋ⚄⤒⏕⌮Ꮫ㸧≉ᐃຓᩍ㸦⚄⤒⏕⌮Ꮫ㸧䝬䝃䜸䝝䝉䜺䝽䝣䝍䜻䚷䚷䚷䚷䚷䚷䚷䝅䝻䜴䜸䜺䝽䚷䚷䚷䚷䚷䚷䜸䝃䝮䝲䝬䝰䝖஧ᮌ䚷ྐᮁ䚷ᩍᤵᑠᕝ䚷ಟ䚷ᩍᤵ

ᒣᮏ䚷ᾈྖ

⁪ᮏ䚷ᬗ

໬Ꮫ◊✲ᡤ
⏕యᶵ⬟タィ໬Ꮫ

་Ꮫ◊✲⛉
Ἢᒀჾ⛉Ꮫ

≉ᐃ෸ᩍᤵ
㸦ᶵᲔᕤᏛ㸧

≉ᐃຓᩍ㸦Ⓨ⏕Ꮫ㸧䜸䜹䝮䝷䚷䚷䚷䚷䝠䝖䝅䝁䝙䝅䚷䚷䚷䚷䚷䚷䜲䜽䜸ᒸᮧ䚷ᆒ䚷ᩍᤵᑠす䚷㑳⏕䚷ᩍᤵ⸆Ꮫ◊✲⛉䝅䝇䝔䝮䝞䜲䜸䝻䝆䞊་Ꮫ◊✲⛉፬ே⛉Ꮫ䞉⏘⛉Ꮫ

䜸䜸 䜶

䝁䜴䝆

䜿䞁䝆

䝍䜻䝰䝖

䝍䜽

䜻䝜䝅䝍

䜰䜻

䝍䜿䝠䝁

኱Ụ䚷㈼἞

ᮌୗ䚷Ṋᙪ

≉ᐃㅮᖌ
䠄ேయゎ๗Ꮫ䞉ศᏊ⏕≀Ꮫ䠅

≉ᐃㅮᖌ㸦ᛂ⏝ᩘᏛ㸧

䝅䝷䜹䝽䚷䚷䚷䚷䚷䝬䝃䝠䝻䜲䝽䝍䚷䚷䚷䚷䚷䚷䝋䜴䚷䝙䝅ⓑᕝ䚷ᫀᏹ䚷ᩍᤵᒾ⏣䚷᝿䚷ᩍᤵ

す䚷⨾ᖾ

㫽஭䚷⨾Ụ

ᕤᏛ◊✲⛉
⏕యศᏊᶵ⬟໬Ꮫ་Ꮫ◊✲⛉ศᏊ⣽⬊᝟ሗᏛ

≉ᐃ෸ᩍᤵ
䠄⏕໬Ꮫ䞉
Ⓨ⏕⏕≀Ꮫ䠅

≉ᐃຓᩍ㸦៏ᛶ࣭⪁ᖺ┳ㆤᏛ㸦ච␿Ꮫ㸧㸧

䝅䝷䜹䝽䚷䚷䚷䚷䚷䚷䝬䝃䝠䝻䜹䜿䝲䚷䚷䚷䚷䚷䚷䚷䝠䝕䜰䜻ⓑᕝ䚷ᫀᏹ䚷ᩍᤵ᥃㇂䚷⚽᫛䚷ᩍᤵᕤᏛ◊✲⛉⏕యศᏊᶵ⬟໬Ꮫ⸆Ꮫ◊✲⛉䝅䝇䝔䝮䜿䝰䝉䝷䝢䞊䞉ไᚚศᏊᏛ䝏䝳䜴䝆䝵䜴䚷䚷䚷䚷䝶䝅䜻䝩䝋䝎䚷䚷䚷䚷䚷䚷䚷䜻䝭䝜䝸୰ᲄ䚷ၿᶞ䚷ᩍᤵ⣽⏣䚷බ๎䚷ᩍᤵ

ᕤᏛ◊✲⛉
㔜ྜ໬Ꮫ

་Ꮫ◊✲⛉
ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ⏕ά⩦័⑓┳ㆤᏛ䜻䝍䜺䝽䚷䚷䚷䚷䚷䝇䝇䝮䝬䝒䝎䚷䚷䚷䚷䚷䝅䝳䜴䜲䝏

䝍䜹 䜸䝸

䝭䝴䜻

䜻䝵䜴䜲䝏

䝖䝸䜲

䜲䝘䝞

䝭䜶

䝘䜸䝁

㧘ᢡ䚷ᜤ୍

✄ሙ䚷┤Ꮚ

≉ᐃ෸ᩍᤵ
㸦⮅⮚እ⛉Ꮫ࣭ప౵く἞⒪Ꮫ㸧≉ᐃຓᩍ㸦⚄⤒⏕⌮Ꮫ㸧

䝍䜹 䜸䝸

䜻䝵䜴䜲䝏

䝁䞁䝗䜴

䜿䞁䝂

㧘ᢡ䚷ᜤ୍

㏆⸨䚷೺ᝅ

≉ᐃ෸ᩍᤵ
㸦⮅⮚እ⛉Ꮫ࣭ప౵く἞⒪Ꮫ㸧≉ᐃຓᩍ㸦་⏝⏕యᕤᏛ㸧

䝍䜹䝝䝅

䝯䜲䝁

䝖䝸䜲

䝭䜶

໭ᕝ䚷㐍䚷ᩍᤵ

ᯇ⏣䚷⚽୍䚷ᩍᤵ㧗ᶫ䚷䜑䛔Ꮚ

㫽஭䚷⨾Ụ

ᕤᏛ◊✲⛉
ᶵ⬟໬Ꮫ

་Ꮫ◊✲⛉
ᩚᙧእ⛉Ꮫ

≉ᐃㅮᖌ
䠄䝀䝜䝮་Ꮫ䠅≉ᐃຓᩍ㸦៏ᛶ࣭⪁ᖺ┳ㆤᏛ㸦ච␿Ꮫ㸧㸧

䝬䝒䝎䚷䚷䚷䚷䚷䚷䜿䞁䝆䝜䝎䚷䚷䚷䚷䚷䚷䚷䝬䝁䝖ᯇ⏣䚷ᘓඣ䚷ᩍᤵ㔝⏣䚷ு䚷ᩍᤵ

Christian Altmann䜽䝸䝇䝏䝱䞁䚷䚷䚷䚷䚷䚷䚷䚷䜰䝹䝖䝬䞁ᕤᏛ◊✲⛉≀⌮᭷ᶵ໬Ꮫ

་Ꮫ◊✲⛉
ศᏊ⭘⒆Ꮫ

་Ꮫ◊✲⛉
≉ᐃ෸ᩍᤵ
䠄ᐇ㦂ᚰ⌮Ꮫ䠅

䝃䝖䜴

䝣䝭䝜䝸

బ⸨䚷ᩥつ
≉ᐃຓᩍ
㸦Ⓨ⏕⏕≀Ꮫ࣭
ศᏊ⏕≀Ꮫ㸧

ᖹᡂ䠎䠒ᖺᗘ䚷LIMSᒚಟ⪅䠄M䠎䠅䞉ᣦᑟᩍᤵ䞉䝯䞁䝍䞊୍ぴ
平成26年度LIMS履修者（M2）・指導教授・メンター 一覧
(ᖹᡂ27ᖺ3᭶31᪥⌧ᅾ)
◊
ᑓ Ꮫ
✲
⛉ ᨷ ᖺ

ᛶ
ู

Ặྡ

ᡤᒓศ㔝

㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬◊✲⛉ᣦᑟᩍᤵ

䝝䜼䝽䝷

་ M
་
1
⛉
Ꮫ
Ꮫ 2

ே
㛫
೺
M
་
2
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Ꮫ
⣔

ே
㛫
೺ M
་
3
ᗣ
Ꮫ
⛉ 2
Ꮫ
⣔

䝃䜽䝬

䝬䜻

బஂ㛫䚷┿⣖䝂䝭䝵䜴䝭䜹䝁஬᫂䚷⨾㤶Ꮚ

䜲䝅䝎

䜰䝒䝁

▼⏣䚷ᩔᏊ

㧗
ศ M
ᕤ
5
Ꮚ
Ꮫ
໬ 2
Ꮫ

䝭䝲䝜䝝䝷

䝆䝳䞁

ᐑஅཎ䚷㑂

䝺䜲

᱔ཎ䚷௧

་Ꮫ◊✲⛉
ᙧែᙧᡂᶵᵓᏛ

ᕤᏛ◊✲⛉ศᏊ⏕≀໬Ꮫ

≉ᐃ෸ᩍᤵ䠄ᶵᲔᕤᏛ䠅

ྜ
ᡂ
䞉 M
ᕤ
7
⏕
Ꮫ
≀ 2
໬
Ꮫ

ྜ
ᡂ
䞉 M
ᕤ
8
⏕
Ꮫ
≀ 2
໬
Ꮫ

䜿䞁

ᮧᑿ䚷㈼

᳨ᰝᢏ⾡⛉Ꮫ䝁䞊䝇ዪ་⒪⏬ീ᝟ሗ䝅䝇䝔䝮Ꮫ

1. ග㉸㡢Ἴ㢧ᚤ㙾䛻䜘䜛⤌⧊ග㉸㡢Ἴ≀ᛶ䛾ᐃ㔞ⓗホ౯䛻㛵䛩䜛◊✲2. ⢓ᙎᛶ≉ᛶ䛾⑓⌮Ꮫⓗデ᩿➼䜈䛾⮫ᗋᛂ⏝

1. ⊂ᒃ㧗㱋⪅䛾ᅾᏯ⏕άᏳ඲ᛶ䛾䝸䝇䜽ホ౯䝒䞊䝹䛸䛧䛶䛾Kinect䛾ಙ㢗ᛶ䜔䝸䝝䝡䝸䝔䞊䝅䝵䞁⛉ጇᙜᛶ䛾᳨ウዪ Ꮫ䝁䞊䝇
⮫ᗋㄆ▱⚄⤒⛉Ꮫ

2. kinect䜢౑⏝䛧䛯IADLືసゎᯒ್䛸㌟యᶵ⬟䠈ㄆ▱ᶵ⬟䛸䛾㛵㐃ᛶ䛾᳨ウ䝅䜲䝘⑓ែᶵ⬟ゎᯒᏛㅮ
㻲㻭㻱㻾㻿䜢฼⏝䛧䛯⬻⾑⟶㞀⏨ ᗙᐖ䝸䝇䜽⸆๣䛾᳨ฟ⏕యᶵ⬟ゎᯒᏛ

䝒䝶䝅᳝ྡ䚷Ẏ䚷ᩍᤵ

ዪ་⏝㧗ศᏊㅮᗙ
⤌⧊ಟ᚟ᮦᩱᏛ

⏨

䝣䝍䜻

䝖䝅䝁

䝍䜽 䝖

⏨

⏨

་Ꮫ◊✲⛉
ங⭢እ⛉Ꮫ

≉ᐃ෸ᩍᤵ
䠄⮫ᗋ⚄⤒⏕⌮Ꮫ䠅

䝘䜹䝧

䚷䜹䝈䝶䝅

䜸䜸䜶

䜿䞁䝆

኱Ụ㈼἞

་Ꮫ◊✲⛉
ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ⮫ᗋㄆ▱⚄⤒⛉Ꮫ

ᕤᏛ◊✲⛉
⇕ᮦᩱຊᏛ

≉ᐃㅮᖌ
䠄ேయゎ๗Ꮫ䞉ศᏊ⏕≀Ꮫ䠅

䝅䝳䜴䝆

䝣䝆䝍

䝆䝳䞁

䝬䝒䝎䚷䚷䚷䚷䚷䚷䚷䝽䝁䝖䚷䚷䚷䚷㔠Ꮚ䚷࿘ྖ䚷ᩍᤵ⸨⏣䚷₶䚷ᩍᤵ

ᯇ⏣䚷࿴㑻

⸆Ꮫ◊✲⛉
⏕యᶵ⬟ゎᯒᏛ

་Ꮫ◊✲⛉
ศᏊ⑓デ⒪Ꮫ

≉ᐃㅮᖌ䠄⚄⤒ゎ๗Ꮫ䞉ゎ๗Ꮫ୍⯡䠅

䜲䝽䝍䜻䝮䝷䚷䚷䚷䚷䚷䝍䜿䝅䝠䝻䜸䝅䞁䝄䝤䝻䜴

䝍䜹 䜸䝸

䜻䝵䜴䜲䝏

ᮌᮧ䚷๛䚷ᩍᤵ

㧘ᢡ䚷ᜤ୍

་Ꮫ◊✲⛉
ᚠ⎔ჾෆ⛉Ꮫ

≉ᐃ෸ᩍᤵ䠄⮅⮚እ⛉Ꮫ䞉ప౵く἞⒪Ꮫ䠅⣽⬊⛣᳜䛻䜘䜛⢾ᒀ⑓἞⒪䛸㧗㱋໬♫఍

䝠䜾䝏䚷䚷䚷䚷䚷䚷䚷䝴䝸䝁ᵽཱྀ䚷䜖䜚Ꮚ

䜹䝽䝜

䜿䞁䝆

䝁䞁䝗䜴

䜿䞁䝂

ఀ⸨䚷⤀୕㑻䚷ᩍᤵἙ㔝䚷᠇஧䚷ᩍᤵ

㏆⸨䚷೺ᝅ

ᕤᏛ◊✲⛉
ᮦᩱᶵ⬟ゎᯒ་Ꮫ◊✲⛉ㄆ▱⾜ື⬻⛉Ꮫ≉ᐃຓᩍ䠄་⏝⏕యᕤᏛ䠅≉ᐃㅮᖌ䠄⏕≀⸆๣Ꮫ䠅

䜻䝜䝅䝍

䝍䜿䝠䝁

ᮌୗ䚷Ṋᙪ

≉ᐃㅮᖌ
䠄ᛂ⏝ᩘᏛ䠅

䝖䝸䜲

䝭䜶

㫽஭䚷⨾Ụ

≉ᐃຓᩍ
䠄៏ᛶ䞉⪁ᖺ┳ㆤᏛ䠄ච␿Ꮫ䠅䠅

䝠䝷䜲

䝲䝇䝝䝹

ᖹ஭䚷ᗣ἞

≉ᐃຓᩍ
䠄⚄⤒⏕⌮Ꮫ䠅

䝍䜻䝰䝖

䜰䜻

⁪ᮏ䚷ᬗ

≉ᐃຓᩍ
䠄Ⓨ⏕Ꮫ䠅

䝝䝉䜺䝽

䝍䜽

㛗㇂ᕝ䚷ᣅ

་⏝㧗ศᏊㅮᗙ
⢭⚄⑌ᝈ䛾䝞䜲䜸䝬䞊䜹䞊ᮦᩱᶵ⬟ゎᯒศ㔝 䛾᥈⣴䝽䝍䝘䝧䚷䚷䚷䚷䚷䝎䜲⏕≀໬Ꮫㅮᗙ
ศᏊ⏕≀໬Ꮫศ㔝 2. ⬨㧊ᑠ⬻ኻㄪ⑕ᝈ⪅䛾䝸䝝䝡䝸䝔䞊䝅䝵䞁䛸௓ㆤ䞉⏕
άᨭ᥼

䝰䝸

䝲䝇䜸

᳃䚷Ὀ⏕䚷ᩍᤵ

ᕤᏛ◊✲⛉ศᏊ⏕≀໬Ꮫ䝙䝅䝭䝴䜻Ώ㑓䚷኱䚷ᩍᤵ

す䚷⨾ᖾ

་Ꮫ◊✲⛉
⏕య᝟ሗ⛉Ꮫ≉ᐃ෸ᩍᤵ䠄⏕໬Ꮫ䞉Ⓨ⏕⏕≀Ꮫ䠅

⏕≀໬Ꮫㅮᗙ
ຍ㱋䛻క䛖೺ᗣ㞀ᐖ䛸⭠ෆ⏕యㄆ㆑໬Ꮫศ㔝 ⣽⳦䛸䛾㛵䜟䜚䛻䛴䛔䛶

1. ⬨㧊ᑠ⬻ኻㄪ⑕䛾ศᏊ⑓⌮Ꮫⓗ▱ぢ
ᒣཱྀ䚷୍┿

䝬䝃䜸

ᯇᶫ䚷┾⏕

୰㒊䚷୺ᩗ䚷ᩍᤵᕤᏛ◊✲⛉⏕యㄆ㆑໬Ꮫ

䝲䝬䜾䝏䚷䚷䚷䜹䝈䝬䝬䝒䝝䝅ᡞ஭䚷㞞࿴䚷ᩍᤵ஧ᮌ䚷ῄᏊ䚷ᩍᤵᱵ⏣䚷┿㒓䚷ᩍᤵỈ⸨䚷ᣅே䚷䝖䜲䚷䚷䚷䚷䚷䚷䚷䚷䝬䝃䜹䝈་Ꮫ◊✲⛉ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ་⒪⏬ീ᝟ሗ䝅䝇䝔䝮Ꮫ䜴䝯䝎䚷䚷䚷䚷䚷䚷䚷䝬䝃䝖

䝇䜲䝖䜴

䝯䞁䝍䞊
⫋ྡ䚸䠄ᑓ㛛ศ㔝䠅⏕యᵓ㐀་Ꮫㅮᗙ 䛜䜣἞⒪䜈䛾ᛂ⏝䜢┠ᣦ䛧ዪᙧែᙧᡂᶵᵓᏛ
䛯䝖䝷䞁䝇䜽䝸䝥䝖䞊䝮ゎᯒ෌⏕་⛉Ꮫ◊✲ᡤ⤌⧊ಟ᚟ᮦᩱᏛ

䝮䝷䜸

䝁䜴䝆

ᒣᮏ䚷ᾈྖ

䜲䝖䜴

㧗
ศ M
ᕤ
6
Ꮚ
Ꮫ
໬ 2
Ꮫ

䝲䝬䝰䝖

᳃䚷Ὀ⏕䚷ᩍᤵ

ᒾ⏣䚷༤ኵ䚷ᩍᤵ䜽䝽䝞䝷䝰䝸䚷䚷䚷䚷䚷䝲䝇䜸ⴗཎ䚷ṇᩄ䚷ᩍᤵ

䜹䝛䝁

⸆ M
⸆
4
⛉
Ꮫ
Ꮫ 2

䝬䝃䝖䝅

LIMSᣦᑟᩍᤵ

䝯䞁䝍䞊⫋ྡ䚸䠄ᑓ㛛ศ㔝䠅䝍䜹䝝䝅䚷䚷䚷䚷䚷䝸䝵䜴䝇䜿䜽䝸䝇䝏䝱䞁䚷䚷䚷䚷䚷䚷䚷䚷䜰䝹䝖䝬䞁㧘ᶫ䚷Ⰻ㍜䚷ᩍᤵ

Christian Altmann

་Ꮫ◊✲⛉
⮫ᗋ⚄⤒Ꮫ

་Ꮫ◊✲⛉
≉ᐃ෸ᩍᤵ
䠄ᐇ㦂ᚰ⌮Ꮫ䠅≉ᐃຓᩍ䠄⚄⤒⏕⌮Ꮫ䠅

䝃䝖䜴

䝣䝭䝜䝸

బ⸨䚷ᩥつ
≉ᐃຓᩍ
䠄Ⓨ⏕⏕≀Ꮫ䞉ศᏊ⏕≀Ꮫ䠅

䜲䝘䝞

䝘䜸䝁

✄ሙ䚷┤Ꮚ

≉ᐃຓᩍ
䠄⚄⤒⏕⌮Ꮫ䠅23

24

Gender

Aila
JohannaF

MBENZAMBAMBINAASSON

Contribution towards theassessement of the inadequaciesof health policy in Democratic
Chemical Biology
Republic of the Congo (DRC)
Laboratory,M
through comparison to JapaneseInstitute for
Chemical Research health policy in term of medicines
control and health insurance
systemTomokoMatsumoto

Basic Laboratory
Study on Problems in Medical
Science,
Ethics for Realizing Regenerative
Medical Laboratory
Medicine
ScienceF

Morphological Brain Age-related changes of neural
Sciencearchitecture

M1
M1

Biofunctional
Design-Chemistry, Association between age-related
Division ofchanges in biorhythm and disease
M
Biochemistry,
onset; chronobiological study andits application to clinical treatment
Institute for
Chemical Research

Kouki
ShinodaKumikoDojo

M1

Division

Grade
M1
M1
M1
M1

SAHA
Liton Kumar

To ensure effective treatment ofcancer to reduce mortality andmorbidity, recognizing the value of
M Radiation Genetics
the importance of chemotherapy
and radoitherapy in the treatmentof cancer

The treatment of leukemia

Masatoshi
Uno

Biomolecular
M Functional
Chemistry

Prediction and validation of theonset mechanism of autoimmune
disease based on disorder in thecytokine network

M1

M1

M

LIMS Research Issues

Itaru
Takeshita

Biomolecular
M Functional
Chemistry

Research on the evaluation ofcarcinogenic risk using DNA
methylation analysis and therelationship between the
carcinogenic risk and life style

M1

Medical Science

Medicine
Medicine

Medical Science
Pharmaceutical Sciences
Bioinformatics andChemical Genomics

Medicine
Medicine

Medical Science

Medicine

Human Health Sciences

Pharmaceutical Sciences
Pharmaceutical Sciences

HiroyukiMatsubara

Disease modeling withpatient-specific iPSCs,
Dept. of ClinicalApplication,
Center for iPS Cell
Research andApplication

Kazumasa
Suenaga

Development of Functional
Polymerization
Optical Materials for Quantifying
M Chemistry,
Biomolecules Based on OrganicPolymer Synthesis
Inorganic Hybrids

M1

12

Department

Student

Hiroki
Enno

M1

11

Molecular
Engineering

10

Engineering

9

Molecular
Engineering

8

Engineering

7

Engineering

6

Polymer Chemistry5

Engineering

4Synthetic Chemistry
and Biological Chemistry3

Engineering

2Synthetic Chemistry
and Biological Chemistry1

Medical Science

Graduate
SchoolLIMS (M1)
Students,
Supervisors
and Mentors (AY2014)(M1) Students,
LIMS
Supervisors
and Mentors (AY2014)

Nobuhiko
NishitaniF

System Biology

The Health Risks of Shift Work

䞉Literature search on therelationship between age-relateddiseases in the elderly and thechemical compounds that induce
them

Functional
Coordination
M Chemistry Field,
Synthetic Chemistry
Course䞉Spatiotemporal control ofbioactive gas molecules and theirclinical applications
䞉Applying photoresponsive
Physical Organic
molecules to organisms
Chemistry Field,
M
Synthetic Chemistry䞉Cooperative assembling
Coursebehavior in organisms(As of March 31, 2015)
LIMS Mentor
position, (research field)

LIMS Mentor
position, (research field)

Academic Supervisor

LIMS Supervisor

Prof. Tatsutoshi
Nakahata

Prof. Taiji
AdachiAki Takimoto

Taku Hasegawa

Disease modeling with patientspecific iPSCs, Center for iPS
Cell Research and Application

Biomechanics, Institutefor Frontier Medical
Sciences

Program-Specific
Assistant Professor(Embryology)

Program-Specific
Assistant Professor(Neurophysiology)

Prof. Shunichi
TakedaProf. Masahiro
HiraokaYu Kimura

Fuminori Sato

Radiation Genetics,
Graduate School of
Medicine

Radiation Oncology andImage-Applied Therapy,
Graduate School of Medicine

Program-Specific
Associate Professor(Polymer Chemistry)

Program-Specific
Assistant Professor(Developmental Biology /Molecular Biology)

Prof. Takeshi
KanekoProf. Toshio
Heike

Yuriko Higuchi

Dinh Ha Duy Thuy

Morphological Brain
Science, Graduate Schoolof Medicine

Pediatrics, Graduate
School of Medicine

Program-SpecificSenior Lecturer(Biopharmaceutics)

Program-Specific
Assistant Professor(Functional
Neuroimaging)

Prof. Uesugi
MotonariProf. Yutaka
Teranishi

Wakoto Matsuda

Yasuharu Hirai

Program-SpecificSenior Lecturer(Neuroanatomy,
Anatomy)Program-Specific
Assistant Professor(Neurophysiology)

Masao Matsuhashi

Taku Hasegawa

Chemical Biology,
Institute for Chemical
Research

Medical Science and Business
Liaison Organization, Graduate
School of Medicine

Prof. Kuniaki
Saito

Prof. Taira
Maekawa

Basic Laboratory Science,
Human Health Sciences,
Graduate School of Medicine

Prof. Shiro
Futaki
Biofunctional DesignChemistry, Institute for
Chemical Research

Transfusion Medicine &Program-Specific
Cell Therapy, Kyoto
Associate Professor
University Hospital(Clinical Neurophysiology)

Prof. Osamu
Ogawa

Koji Yamamoto

Program-Specific
Urology, Graduate School
Associate Professorof Medicine(Mechanical Engineering)

Program-Specific
Assistant Professor(Neurophysiology)

Aki Takimoto
Program-Specific
Assistant Professor(Embryology)

Prof. Hitoshi
OkamuraProf. Ikuo
KonishiKenji Ohe

Takehiko Kinoshita

System Biology, Graduate
School of Pharmaceutical
Sciences

Gynecology and
Obstetrics, Graduate
School of Medicine

Program-SpecificSenior Lecturer(Human Anatomy / Molecular
Biology)

Program-SpecificSenior Lecturer(Applied Mathematics)

Prof. Masahiro
ShirakawaProf. So
Iwata

Biomolecular Functional
Chemistry, Graduate
School of Engineering

Cell Biology, Graduate
School of Medicine

Prof. Masahiro
ShirakawaProf. Hideaki
KakeyaBiomolecular Functional
Chemistry, Graduate
School of Engineering

Prof. Yoshiki
Chujo

Miyuki Nishi

Mie Torii

Program-Specific Associate
Professor(Biochemistry / Developmental
Biology)

Program-Specific
Assistant Professor(Gerontological Nursing(Immunology))

Kyoichi Takaori

System Chemotherapy andProgram-Specific Associate
Molecular Sciences, Graduate
Professor
School of Pharmaceutical(Pancreatic Surgery / Minimally
Sciences
Invasive Therapeutics)

Prof. Kiminori
HosodaKyoichi Takaori

Naoko Inaba
Program-Specific
Assistant Professor(Neurophysiology)

Kengo Kondo

Polymerization Chemistry, Nursing Science for Lifestyle- Program-Specific Associate
Program-Specific
Related Diseases, Human
Professor
Graduate School ofAssistant Professor
Health Sciences, Graduate (Pancreatic Surgery / Minimally
Engineering(Medical Biotechnology)
School of Medicine
Invasive Therapeutics)

Prof. Susumu
Kitagawa

Prof. Shuichi
MatsudaMeiko Takahashi

Mie Torii

Program-SpecificSenior Lecturer(Genomic Medicine)

Program-Specific
Assistant Professor(Gerontological Nursing(Immunology))

Functional Coordination
Chemistry, Graduate
School of Engineering

Orthopaedic Surgery,
Graduate School of
Medicine

Prof. Kenji
MatsudaProf. Makoto
Noda

Christian Altmann

Fuminori Sato

Physical Organic
Chemistry Field, Graduate
School of Engineering

Molecular Oncology,
Graduate School of
Medicine

Program-Specific Associate
Professor, Graduate School of
Medicine(Experimental Psychology)

Program-Specific
Assistant Professor(Developmental Biology /Molecular Biology)

Gender

Grade

Division

Medical Science

M2
M2

Transcriptome analysis
with application incancer treatment

䞉Quantitative assessmentof photoacoustic propertiesof biological tissues byphotoacoustic microscopy

Medical Imaging
System Sciences,
F
Laboratory Science 䞉Applying viscoelastic
Courseproperties for pathology

䞉An investigation ofreliability and validity on
Kinect as the tool of safety
life for older adults

LIMS Supervisor

Prof. Masatoshi
Hagiwara

Prof. Yasuo
Mori

Anatomy andDevelopmental
Biology, Graduate
School of Medicine

Molecular Biology,
Graduate School ofEngineering

Prof. Tsuyoshi
ShiinaProf. Masakazu
Toi

Medical Imaging
System Sciences,
Human Health
Sciences, Graduate
School of Medicine

Breast Surgery,
Graduate School of
Medicine

Prof. Toshiko
FutakiProf. Kazuyoshi
NakabeM2

Human Health Sciences

Anatomy andF Developmental
Biology

AtsukoIshidaJun
Miyanohara

Molecular
M
Pharmacology

Detection of high-riskdrugs forcerebrovasculardiseases using FAERS

Rei
Kuwabara

Reparative
Materials,
F
Biomaterials
DesignProf. Hiroo
Meaning of treatment of
Iwata
diabetics by celltransplantation in aged
Reparative Materials,
society.
Institute for Frontier
Medical Sciences

Ken
Murao

Material Function
and Analysis,M
Biomaterials
DesignInvestigation of
biomarker for mental
disorderTakutoSuito

Biorecognics Field, Study on age-relateddisease and gut
M Biological
Chemistry Course microbiome

KazumaYamaguchi

Molecular Biology
Filed,
M Biological
Chemistry
Course(As of March 31, 2015)

Academic Supervisor

M2

Human Health Sciences

LIMS Research Issues

Clinical Cognitive
F Neuroscience,
Rehabilitation
Sciences Course

M2

Pharmaceutical Sciences

MikakoGomyo

Department

and other clinicaldiagnoses

M2

Polymer Chemistry

Maki
SakumaM2

Polymer Chemistry

Student

M2

Graduate
SchoolMedicine
Medicine

8

Pharmaceutical Sciences

7

Engineering

6

Engineering

5

Engineering

4Synthetic Chemistry andBiological Chemistry3

Engineering

2Synthetic Chemistry and Biological
Chemistry

1

Medicine

LIMS (M2)Supervisors
and Mentors(AY2014)(AY2014)(M2Students,) Students,
LIMS
Supervisors
and Mentors

Clinical Cognitive䞉An investigation of the
Mechanics of Thermal
relationships between IADL Neuroscience, Human
Fluid and Material,
motion analysis value,
Health Sciences,
Graduate School ofphysical function andGraduate School ofEngineering
cognitive function by using
Medicine
Kinect䞉Molecular pathologicalstudy of spinocerebellar
ataxia.
䞉Nursing care andrehabilitation forpatients withspinocerebellar ataxia.

Prof. Shuji
KanekoMolecular
Pharmacology,
Graduate School of
Pharmaceutical
Sciences

Prof. Shinzaburo
ItoProf. Jun
FujitaClinical Molecular
Biology, Graduate
School of Medicine

Prof. Takeshi
KimuraCardiovascular
Medicine, Graduate
School of Medicine

Prof. Kenji
KawanoMaterial Function andAnalysis, Graduate
School of Engineering

Integrative Brain
Science, Graduate
School of Medicine

Prof. Masato
Umeda

Prof. Dai
Watanabe

Biorecognics,
Graduate School ofEngineering

Biological Sciences,
Graduate School of
Medicine

Prof. Yasuo
MoriProf. Ryosuke
Takahashi

Molecular Biology,
Graduate School ofEngineering

Neurology, Graduate
School of Medicine

LIMS Mentor
position, (research field)

LIMS Mentor
position, (research field)

Koji Yamamoto

Yuriko Higuchi

Program-Specific
Associate Professor(MechanicalEngineering)

Program-SpecificSenior Lecturer(Biopharmaceutics)

Masao Matsuhashi

Takehiko Kinoshita

Program-Specific
Program-Specific
Associate Professor
Senior Lecturer(Clinical(Applied Mathematics)
Neurophysiology)

Kenji Ohe

Mie Torii

Program-SpecificSenior Lecturer(Human Anatomy /Molecular Biology)

Program-Specific
Assistant Professor(GerontologicalNursing(Immunology))

Wakoto Matsuda

Yasuharu Hirai

Program-SpecificSenior Lecturer(Neuroanatomy,
Anatomy)Program-Specific
Assistant Professor(Neurophysiology)

Kyoichi Takaori

Aki Takimoto

Program-Specific
Associate Professor(Pancreatic Surgery /Minimally Invasive
Therapeutics)

Program-Specific
Assistant Professor(Embryology)

Kengo Kondo

Taku Hasegawa

Program-Specific
Assistant Professor(Medical
Biotechnology)

Program-Specific
Assistant Professor(Neurophysiology)

Miyuki Nishi

Fuminori Sato

Program-Specific
Associate Professor(Biochemistry /Developmental
Biology)

Program-Specific
Assistant Professor(Developmental
Biology / Molecular
Biology)

Christian Altmann

Naoko Inaba

Program-Specific
Associate Professor,
Graduate School of
Medicine(Experimental
Psychology)

Program-Specific
Assistant Professor(Neurophysiology)

25

26

2.
教育カリキュラム及び指導体制
Curriculum and Staff

平成26年度

履修科目表
修士

科目群

基盤
科目

科

工学

目

３年次

４年次

５年次

前

前

前

２

医用電子工学

椎名・杉本

２

材料化学基礎

近藤・木村祐高分子医工学

岩田

連続体力学

安達

２

生物分子解析学

森・西２

画像処理の基礎

杉本・椎名

薬学

薬物動態学

中山・高倉・
橋田・樋口

医学・
生物学

人体解剖学

萩原・金子・
大江・松田和生理学

大森・河野・
金子

医化学

渡邉

加齢医学

荒井

再生医学

開・瀬原・
田畑・安達

ゲノムコホート研究

松田文・高橋２

小杉・藤田・福山１

木下

シミュレーション概論

木下

医療経済論

後藤・富塚

知的財産 &国際標準化

寺西医療工学 医療工学特別講義Ⅰ
特別講義
医療工学特別講義Ⅱ

後

後

後

備

考

後

7月・8月
２
２

２
２

必修

5

必修
（9月〜）

２

4月・3月

２
２
２

２
２
２
２

石井

（9月〜）

２

石井

２

（9月〜）

A. 学際応用科目
1 画像診断学：講義
1ー1 病理画像診断学

羽賀

1ー2 放射線画像診断学

福山

1ー3 MRI 画像診断学

福山2 低侵襲治療学：講義

木村剛・高折3 生体材料学・人工臓器学：講義

田畑・松田秀１

4 医療情報学：講義

黒田

１

5 検査機器学・研究機器学
：講義

一山

１

6 医療・生活支援システム学：講義

椎名

6ー1 生体検査・画像解析法
6ー2 在宅医療支援
6ー3 リハビリテーション

28

２年次
前

後

中部・安達・山本

数理科学 基礎数学

学際応
用科目

１年次
前

機械工学基礎

医療倫理 医療倫理

医療
経済学

担当者

博士後期

１

（9月〜）

１
１

１

9月・10月

必修
4月・5月

修士
科目群

学際応
用科目

科

目

担当者

博士後期

１年次

２年次

３年次

４年次

５年次

前

前

前

前

前

後

後

後

後

備

考

後

B. 実習及び病院内研修
1 画像診断学：実習
1ー1 病理画像診断学

羽賀

1ー2 放射線画像診断学

福山

1ー3 MRI 画像診断学

福山2 低侵襲治療学：実習

木村剛・高折3 生体材料学・人工臓器学：実習

田畑・松田秀１

4 医療情報学：実習

黒田

１

5 検査機器学・研究機器学
：実習

一山

１

6 医療・生活支援システム学：実習・見学椎名

6ー1 生体検査・画像解析法

１

（9月〜）

１
１

9月・10月

必修
4月・5月

１

6ー2 在宅医療支援機関
6ー3 リハビリテーション部
英語 debateⅠ

Altmann

英語 debateⅡ

Altmann

インターン 短期海外インターンシップ
シップ
企業インターンシップ

武田・福山

１

必修

１
１

１

石井・福山

必修
選択
必修

プレリサーチ

必修

特別研究

必修

網掛けは開講学年・学期、数字は単位数
学際応用科目は、講義及び実習の両方を受講しないと単位は認められない。

29

Curriculum (Academic Year 2014)
ＭＣ

Subjects

No

Lecturer

Mechanics and Dynamics,
Fundamental

Nakabe, Adachi, Yamamoto22

Medical Electronics

Shiina, Sugimoto2

3

Basic Materials Chemistry

Kondo, Y.Kimura

4

Biomaterials: Materials for preparation of
Iwata
medical devices and regenerative medicine

5

Continuum Mechanics

Adachi2

6

Molecular Analysis of LifeMori, Nishi

2

7

Image Processing Basics

Sugimoto, Shiina

8Biopharmaceutics

Nakayama, Takakura,
Hashida, Higuchi

9

Human Anatomy

Hagiwara, Kaneko,
Ohe, W.Matsuda

Ohmori, Kawano, Kaneko

11 Medical Chemistry

WatanabeJul. Aug.

2
2

2
2
5

Compulsory
Compulsory(Sep.～)

2
2

Apr. Mar.

12 Gerontology, Geriatrics, and Aging Science Arai2

13 Regenerative Medicine

Hiraki, Sehara, Tabata, Adachi

14 Genome Cohort Study

F.Matsuda, Takahashi

2

15 Medical Ethics

Fukuyama, Kosugi, Fujita

1

16 Basic Mathematics

Kinoshita

17 Introduction to Ｎumerical Simulation

Kinoshita

18 Health Economics

Goto, Tomizuka

19Intellectual Property & Global
Standardization

2

2
2
2

Teranishi

20 Medical Engineering for Society Ⅰ

Ishii

21 Medical Engineering for Society Ⅱ

Ishii

Remarks

1st 2nd 1st 2nd 1st 2nd 1st 2nd 1st 2nd
Sem Sem Sem Sem Sem Sem Sem Sem Sem Sem

1

10 Physiology

ＤＣ

1st Grade 2nd Grade 3rd Grade 4th Grade 5th Grade

2
2

Sep.～

2

Sep.～

◆ Interdisciplinary application （1～6）
1. Medical imaging: Lecture
22

1-1 Diagnostic Pathology

Haga

23

1-2 Radiology

Fukuyama

24

1-3 MRI introduction

Fukuyama

11

2. Minimally invasive therapeutics :T.Kimura, Takaori
Lecture3. Biomaterials and Artificial Organs :26
Tabata, S.Matsuda
Lecture

1

25

30

Sep.～

1

27

4. Medical informatics : Lecture

Kuroda1

28

5. Inspection equipment studies
Science research equipment :LectureIchiyama

129

6. Medical and life support
systems : Lecture

Shiina1

Sep. Oct.

Compulsory(Apr. May)

ＭＣ

Subjects

No

LecturerＤＣ

1st Grade 2nd Grade 3rd Grade 4th Grade 5th Grade

Remarks

1st 2nd 1st 2nd 1st 2nd 1st 2nd 1st 2nd
Sem Sem Sem Sem Sem Sem Sem Sem Sem Sem

1. Medical imaging : Practice22

1-1 Diagnostic Pathology

Haga

23

1-2 Radiology

Fukuyama

24

1-3 MRI introduction

Fukuyama

11

2. Minimally invasive therapeutics :T.Kimura, Takaori
Practice
3. Biomaterials and Artificial Organs :26
Tabata, S.Matsuda
Practice

Sep.～

1

25

1

27

4. Medical informatics: Practice

Kuroda1

28

5. Inspection equipment studies
Science research equipment :Practice

Ichiyama

129

6. Medical and life support
systems : PracticeShiina1

30 Debate Ⅰ

Altmann1

31 Debate Ⅱ

Altmann

32 Internship (Abroad )Takeda, Fukuyama

Sep. Oct.

Compulsory(Apr. May)

1

Compulsory

1

1

33 Internship (Industrial and public parties) Ishii，Fukuyama

Compulsory
Compulsory
elective

34 Pre-research

Compulsory

35 Thesis Research

Compulsory

Number: The number of credits
Note: Students must take both the lecture and practice for "the Interdisciplinary application".

31

特定教員の配置と活動

京都大学では、博士課程教育リーディングプログラムを学際融合教育研究推進センターの制度を活用して運営している（図１）。LIMS プログラムでは、学際的な教育の促進と個々の履修生に対する多角的な観点からの指導のため、関連分野にわたって特定教員を採用した（図２）。

講義・実習・研修
特定教員（教授・准教授・講師）はプログラム科目を担当し、特定助教も実習・研修の実施を担当した。又次年度以降開講の講義・実習の準備を行った。履修生３回生以降のコロキウム・特別研究については、個々の特定教員の専門分野に応じて担当する予定である。次ページ以降に、具体的な実施状況の一部を記す：
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.

人体解剖学 ------------------------------------------- 大江 賢治 ・ 松田 和郎
生理学 ------------------------------------------------- 松田 和郎 ・ 稲場 直子 ・ 平井 康治
医療・生活支援システム学（生体検査・画像解析法、リハビリテーション）----------- 近藤 健悟
医療・生活支援システム学（在宅医療支援）------------------------------------------------ 鳥井 美江
英語 debate ------------------------------------------- Christian Altmann
機械工学基礎 ---------------------------------------- 山本 浩司
材料化学基礎 ---------------------------------------- 木村 祐
生物分子解析学 ------------------------------------- 西 美幸
薬物動態学 ----------------------------------------- 樋口 ゆり子
医化学 ------------------------------------------------- 長谷川 拓
再生医学 ---------------------------------------------- 佐藤 文規 ・ 滝本 晶
ゲノムコホート研究 ------------------------------- 高橋 めい子
基礎数学 ---------------------------------------------- 木下 武彦
シミュレーション概 論 ------------------------------ 木下 武彦
医療経済論 ---------------------------------------- 富塚 太郎
低侵襲治療学 ---------------------------------------- 髙折 恭一
医療工学特別講義Ⅰ、Ⅱ： （産公学連携の章参照）

メンター
各履修生について、専門分野の指導教員のほか、LIMS プログラムの教育研究課題を学生・指導教員とともに企画し、学生の自主的な課題遂行を支援・助言するため、専門分野と関連を持ちながらも異なる分野から、LIMS 指導教員（教授）１名とメンター２名を設定した。特定教員がメンターの任に当たり、特別研究への準備段階であるプレリサーチについても、助言・指導を行った。

32

1

学際融合教育研究推進センター・ユニットによる運営

•
•
•
•
総長

総長室

部局横断型の教育や研究プロジェクト
部局

企画担当理事

ユニット

部局
ユニット
新
ユニット

ユニット

部局に属さない
プロジェクト等

ユニット

学際融合教育研究推進センター

連携

学際
センター

部局 ユニット

大学
本部

ユニット

ユニット

ユニット

ユニット

学際人材育成システム

新研究展開システム

学融合フェロー

2

ユニット
部局

・ ・・
行政
産業界等

特定教員の配置33

実施状況

1. 人体解剖学
担当者 ： 萩原 正敏 教授（医学研究科・形態形成機構学）
金子 武嗣 教授（医学研究科・高次脳形態学）
山田 重人 教授（医学研究科・人間健康科学系専攻・運動機能解析学）
青山 朋樹 准教授（医学研究科・人間健康科学系専攻・運動機能開発学）
大江 賢治 特定講師（LIMS）
松田 和郎 特定講師（LIMS）
人体解剖学は、LIMS履修生２年前期の基盤科目であり、超高齢社会において重要となる筋・骨格系
講義と運動学を重視した内容である。履修生が、人体解剖学の講義と実習を通して、医工連携に不可欠な人体の「構造」と「機能」の連関を理解してもらうことを目標としている。本年度は、医学部学生の使用する教科書を参考にして講義プリントを適宜配布し、レポート提出による習熟度チェックも行なった。実習では、医学部学生が学習する実際のご遺体に触れさせ、バーチャル画像や樹脂模型を使って、立体的に人体の構造を理解させた。系統解剖を体験させることが、本プログラムにおける人体解剖学の大きな特長である。

2. 生理学
担当者 ： 大森 治紀 教授（医学研究科・神経生物学）
河野 憲二 教授（医学研究科・認知行動脳科学）
金子 武嗣 教授（医学研究科・高次脳形態学）
松田 和郎 特定講師（LIMS）
稲場 直子 特定助教（LIMS）
平井 康治 特定助教（LIMS）
本育成プログラムの目指すところである『医療現場のニーズに立脚した総合医療システムの開発者並びにこれを統率するリーダー』に求められる医学の基礎知識として、生理学の講義を基盤科目・必修として修士1回生の後期（9-12月）に行った。この講義は、特に工学系出身の学生に対し、医学部卒業生に匹敵する医学・生理学の知識を与えることを目標としている。講義は医学部学生を対象として行われるものと同等のクオリティを目指し、特に重要と思われる以下の内容を厳選して行った。
1.

生命に必要な生体の恒常性とそれを支える神経系について

2.

神経の働きを理解するのに必要な膜興奮性と神経活動、シナプスの構造と働きについて

3.

脳の構造と機能、及び感覚受容について

4.

生命維持に特に重要な心臓・循環及び肺・呼吸について理解程度の確認のために、履修生には内容ごとにレポートを課し、評価した。
３月には、医学部学生に向けた生理学実習で用いる実験装置を実際に使用しながら、生理学実験を行うための手法、並びに解析方法についての指導を行った。

34

3. 医療・生活支援システム学（生体検査・画像解析法、リハビリテーション）
担当者 ： 椎名 毅

教授（医学研究科・人間健康科学系専攻・医療画像情報システム学）

齋藤 邦明 教授（医学研究科・人間健康科学系専攻・基礎検査展開学）
杉本 直三 教授（医学研究科・人間健康科学系専攻・先進医療機器開発学）
足立 壮一 教授（医学研究科・人間健康科学系専攻・検査応用開発学）
黒木 裕士 教授（医学研究科・人間健康科学系専攻・運動機能解析学）
山根寛 教授（医学研究科・人間健康科学系専攻・脳機能リハビリテーション学）

二木 淑子 教授（医学研究科・人間健康科学系専攻・臨床認知神経科学）
加藤 寿宏 准教授（医学研究科・人間健康科学系専攻・脳機能リハビリテーション学）
平松 英文 講師（医学部附属病院・小児科）
近藤 健悟 特定助教（LIMS）
医療の現場において検査や画像解析に関する先進医療機器、また在宅医療介護やリハビリテーショ
ンにおいて医療支援システムがどのように応用されているかを理解することを目的とし、講義および実習を行った。
【生体検査・画像解析法】
1. 講義
1.1 オミックス解析による病態解析
臨床検査の医療における役割と新しい診断薬開発の方向性を学んだ。
・ 個別化医療における臨床検査の役割：先制医療、コンパニオン診断
・ 新たな診断薬開発のためのオミックス解析による病態解析：プロテオミクス、メタボロミクス、ゲノミクス
・ 新たな免疫制御因子 IDO：創薬と診断薬開発
1.2 医用画像機器
生体組織の形態や機能を画像化する様々な医用画像機器についての特徴および原理の概要を学んだ。また、それらによって得られる種々の臓器の画像の例、さらに同じ部位を異なる方法で画像化し、それぞれの特徴を比較した。
・ 様々な臓器の形態画像：胸部 X 線、胃 X 線造影、消化管撮影、冠動脈造影、マンモグラフィ、断層撮影装置、頭部 X 線 CT、心臓３次元 X 線 CT、全身 MRI・ 頭部の様々な画像（形態や機能）：X 線 CT、MRI、SPECT、PET、fMRI、脳血管造影、MRA、NIRS・ 光、超音波による形態や機能の可視化：サーモグラフィ、眼底写真、眼底 OCT、内視鏡（胃）、内視鏡（大腸）、カプセル内視鏡、内視鏡（血管）、超音波内視鏡、腹部超音波
2. 実習
生体検査法として、フローサイトメトリーについての講義および実習を行った。まず、フローサイトメトリーの原理およびそれによって得られる情報、適用対象についての講義を行った。実習では、フローサイトメーターを用いて血液を計測した。また蛍光標識抗体の有無による結果の違いを観察するなどし、検査装置によって得られる情報について考察した。

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3. 学外研修
医用画像機器、検査機器を開発する島津製作所を訪問し、分析装置や画像診断機器等について見学を行った。それぞれの装置の説明を受けるとともに、開発における話を伺う、実際に触れるなどし、様々な機器やその開発、応用について学んだ。また X 線画像診断装置等の画像診断機器の製造過程を見学し、医療機器がどのように製造されているかを学んだ。
【リハビリテーション】
超高齢社会をむかえた我が国において、高齢者リハビリテーションは喫緊の解決すべき課題である。リ
ハビリテーション（理学療法、作業療法）についてその概要を学ぶと共に、リハビリテーションにおける医療・福祉・在宅ケアの統合の重要性を理解し、さらに従来の医工連携の枠組みを超えて、医療現場のニーズに立脚した総合医療システムを開発する医工学の必要性を考察することを目的に講義、実習を
行った。
1. 講義
リハビリテーション（理学療法、作業療法）について、その概要を学んだ。
1.1 理学療法
・ 何が求められているか
・ 現状認識：高齢化率と障害、疾病、平均在院日数・ 回復期リハビリテーション病棟
・ 病院で完結しないリハビリテーション：維持期リハビリテーションの重要性
・ リハビリテーションの語源
・ 理学療法の対象と領域
・ 新たな機器開発の時代
1.2 作業療法
・ 作業療法について：語源、特性、機能、対象、手段、領域
・ 作業療法でもちいる作業・ 歴史、日本および世界における作業療法士数、養成施設数・ 作業療法の分類
・ 精神認知機能領域作業療法
・ 身体障害領域作業療法
・ 障害の具体例、リハビリテーションの具体例
2. 実習
京都大学医学部附属病院のリハビリテーション部において、理学療法士、作業療法士に付き、リハビリ
テーションの臨床で行われている理学療法、作業療法それぞれについて現場の見学を行うことにより講義で学んだリハビリテーションについての理解を深めた。

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4. 医療・生活支援システム学（在宅医療支援）担当者 ： 荒井 秀典 教授 （医学研究科・人間健康科学系専攻・近未来システム・技術創造部門）
鳥井 美江 特定助教（LIMS）
4人に1人が高齢者という超高齢社会である我が国は、高齢者やその家族のニーズは多様化し、介護・医療・福祉分野における対策が急務とされている。厚生労働省は、自立した生活を支援し、高齢者が住み慣れた地域での住宅生活を継続することができるように地域の包括的な支援・サービスの構築（地域包括ケア）を推進している。地域包括ケアを実現するためには、医療分野・介護分野の連携強化、介護サービスの充実、予防の推進、生活支援サービスの確保、住まいの整備などが必要とされている。
在宅医療支援分野では、高齢者への支援や療養生活を見学・体験することで地域医療・介護現場において高齢者やその家族が抱えている問題に触れ、対象者のニーズに沿った医療支援システムの構築や機器開発などの考察を目的として、講義と臨地実習を行った。講義は、高齢者概論、福祉政策を中心に行い、臨地実習では、高齢者施設や公的支援センターの見学、リハビリテーションの体験を行った。
（１）講義① 高齢社会と背景： 国内、諸外国の高齢化の現状や政策、今後の動向と起こりうる問題② 高齢者の身体的・生理的特徴と変化、 社会役割・精神的特徴と変化③ 高齢者が罹患しやすい疾患④ 高齢者福祉政策： 介護保険制度の概要、介護保険制度創設・施行までの社会的背景、
介護保険制度のサービス内容と手続き方法（２）臨地実習① 高の原ポシブルデイケアセンター：
生活リハビリに特化した新しいデイサービス施設である。ノルウェー、フィンランドなどの福祉先進国から最新トレーニング機器を導入し、理学療法士が利用者それぞれの目標を設定し、目標達成に必要な筋力トレーニングプログラムを作成し、機能評価をする。実習では実際にプログラムに参加し、予防やリハビリテーションの重要性について学びを深めた。
② 高齢者福祉施設：
介護老人福祉施設（特別養護老人ホーム）、短期入所生活介護・介護予防短期入所生活介護（ショートステイ）、通所介護・介護予防通所介護（デイサービスセンター）が複合した施設である。市内の高校と同じ敷地内にあり、デイサービスセンターにおいては地域の乳幼児と母親も利用していることから高齢者と様々な年代の地域住民とのふれあいの場にもなっている。高齢者の生活を見学する中で、それぞれの施設の特性と地域連携、生活支援サービスについて学びを深めた。
③ 地域包括支援センター、透析施設、鍼灸院
ケアマネジャー、保健師、社会福祉士が連携して地域高齢者の介護・福祉・健康・医療などさまざまな面から総合的に支援する公的相談窓口である。実習では、ケアマネジャーから施設の概要や支援内
容、事例紹介を受け、高齢者の現状だけでなく、ケアマネジャーが抱える問題にも触れ、医療・介護分野の連携について学んだ。また、隣接している透析施設、鍼灸院の見学を行い、在宅療養者の生活についても学びを深めた。

5. 英語 debate
担当者 ： Christian F. Altmann, Program-Specific Associate Professor, Graduate School of Medicine（英文の頁参照）37

6. 機械工学基礎
担当者 ： 中部 主敬 教授（工学研究科・機械理工学専攻）
安達 泰治 教授（再生医科学研究所）
山本 浩司 特定准教授（LIMS）
本コースの目的は、非機械系の学生が機械工学の基礎となる四力学(機械力学、材料力学、流体力
学、熱力学)を中心に学び、医工学や福祉分野における新たなデバイス開発や計測システムの構築に必要となる機械工学的感性を修得することにある。本年度は受講生２名に対し、週１回３時間(２コマ)の講義
を７月、８月の２カ月間行った。前半は、上述の四力学を連続体の概念を交えて説明し、数理的な運動
方程式や支配方程式と実現象との繋がりに焦点を当てた。具体的には、質量と大きさを持つ物体の変位・変形、あるいは気体や液体の流れといった身近な現象を数理的に解説し、式の持つ物理的意味の説明を行った。後半は前半で学んだ力学原理の応用事例を実際の機器やシステムを用いて紹介し、加えて最新の医療・福祉工学や医工学テクノロジーに関する解説を行った。また、修士２回生を対象とした実習は、生体材料学・人工臓器学の一環として行われた。

7. 生物分子解析学
近藤 輝幸 教授（学際融合教育研究推進センター・先端医工学研究ユニット）木村

祐 特定准教授（LIMS）（英文の頁参照）

8. 生物分子解析学
担当者 ： 森西泰生 教授（工学研究科・合成・生物化学専攻）
美幸 特定准教授（LIMS）

生物分子解析学の講義は修士1年の後期に行われる。講義は、生物学に馴染みの少ない物理、化学を中心とした高校時の授業の後、大学入学後も生物学の講義の機会が少ない学生を対象にしている。その後のLIMSで提供される医学、薬学の専門科目への橋渡し的な役割を担っている。講義は基礎的な生物学に始まり汎用性の高い高度な機器を使った実習を行った。今年度は、遺伝子とタンパク質の構造と機能、シグナル伝達に関係するタンパク質郡とセカンドメッセンジャーの動態解析に焦点を当てた講義と実習を行った。
１．遺伝子の機能：講義及び自身の遺伝子型の決定
２．タンパク質の解析：講義及び質量分析の実習
３．カルシウムシグナリングと温度センサー：講義及び培養細胞を使った実習
４．フローサイトメトリー：講義及びセルソーターを使った実習

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9. 薬物動態学
担当者 ： 中山 和久 教授（薬学研究科・薬科学専攻）
髙倉 喜信 教授（薬学研究科・薬学専攻）
橋田充 教授（薬学研究科・薬学専攻）

樋口 ゆり子 特定講師（LIMS）
薬物動態学の講義は修士２年の後期に提供される。講義では、薬物の生体内における動態、すなわ
ち吸収、分布、代謝、排泄を理解するのに必要な解剖学的・生理学特徴を解説した後、各過程における薬物動態のメカニズムを講義した。また、薬物の体内動態制御法すなわちドラッグデリバリーシステムについての基本的な概念と実例、さらに、核酸医薬品や細胞性製剤など次世代医薬品のDDS開発について紹介した。また、講義内容の理解を深めることができるように、学生による英語でのショートプレゼン
テーションを取り入れた。
・注射により投与された薬物の吸収過程と影響因子、および吸収動態制御法
・皮膚の解剖学的、生理学的特徴、薬物の経皮吸収
・消化管の構造、機能、薬物の消化管吸収・消化管以外の粘膜部位（直腸、肺、鼻）における薬物吸収・薬物が各組織に分布する際の支配因子
・血液-脳関門、血液-脳脊髄液関門、胎盤関門の意義と薬物の脳、胎児への移行
・腎臓の構造、機能と薬物の尿中排泄機構
・薬物の胆汁排泄と腸肝循環
・薬物代謝様式とそれに関与する代表的な代謝酵素
・薬物相互作用・臨床薬物動態学の基礎
・タンパク質医薬品、核酸医薬品のＤＤＳおよび細胞治療用のＤＤＳ

10. 医化学
担当者 ： 渡邉大 教授 （医学研究科・生体情報科学）

柳田 素子 教授 （医学研究科・腎臓内科学）
長田 重一 教授 （医学研究科・医化学）
湊

長博 教授 （医学研究科・免疫細胞生物学）

野田亮 教授 （医学研究科・分子腫瘍学）

長谷川 拓 特定助教 （LIMS）
この科目では工学系のバックグラウンドを持つ本プログラム履修生を主な対象とし、現代社会において課題となっている疾患に関する知識を身に着けることを目標としている。具体的には、医学研究科の教授と協力し、疾患のメカニズム及び現在の治療法に関して生化学・分子生物学的側面から解説を行う。主に、医学部の２、３回生が学ぶ範囲を想定しており、分子生物学の教科書的な話から糖尿病や癌など大きな社会問題になっている病気のメカニズムに関して講義を行う。本年度は４月・５月にM１及びM２の学生を対象に実施した。
履修生が疾患に関する知識を身に着けることで、将来新たな治療方法や医療機器の開発に携わる際に役立つことを期待している。さらに、主な対象としている工学系の知識を持つ履修生だけでなく、生物学系のバックグランウドを持つ履修生にとっても身近に起こり得る疾患の側面から生化学・分子生物学を学ぶことは貴重な体験であったと思われる。

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11. 再生医学担当者 ： 岩田 博夫 教授（再生医科学研究所）
開祐司 教授（再生医科学研究所）

瀬原 淳子 教授（再生医科学研究所）
田畑 泰彦 教授（再生医科学研究所）
安達 泰治 教授（再生医科学研究所）
末盛 博文 准教授（再生医科学研究所）
山本 雅哉 准教授（再生医科学研究所）
佐藤 文規 特定助教（LIMS）
滝本

晶 特定助教（LIMS）

最近のiPS細胞をはじめとする幹細胞研究とその臨床応用技術の躍進により、様々な医療分野において再生医学に関連する知識を包括的に理解することがますます重要になってきている。再生医科学研
究所は再生医学に関連した基礎生物学、幹細胞生物学だけではなく、工学さらには再生医学応用学を研究対象とした研究所である。2014年度の後期に開講した本講義では、再生医科学研究所の教員により、修士1回生と修士2回生を対象として以下の講義を行った。
• ES/iPS細胞などの多能性幹細胞研究の歴史。ヒト多能性幹細胞の樹立とその性質。臨床応用に向けての技術開発。
• 細胞分化と幹細胞 (I), (II)
• 硬組織の形成と再生 (I) ECM, (II) 成長と分化成熟, (III) 運動器パーツの接続• 細胞を望む位置に配置して組織の構築を試みる• バイオマテリアルの定義およびその医療機器とドラッグデリバリーシステム(DDS)への応用• バイオマテリアルから見た再生医療-再生研究と再生治療• 硬組織再生医療における材料工学の重要性• 体外での生体組織様構造物の作製とその応用• 再生医療におけるナノテクノロジー• 骨の再生・再構築の数理バイオメカニクスとスキャフォールド構造設計• 多細胞組織の形態形成ダイナミクスの数理バイオメカニクス
幹細胞、細胞分化、生体組織の構築、及び材料工学に関する講義では、基礎生物学から再生医学応用学までを一連の講義で学ぶことにより、基礎から応用への繋がりを理解させることに重点をおいた。さらにはバイオメカニクス分野の講義も行い、受講学生が、生物学から工学そして力学と、再生医学・医療に関わる最新の知識を身につけることを目指した。

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12. ゲノムコホート研究担当者 ： 高橋 めい子 特定講師 (LIMS)「ゲノムコホート研究」は、ゲノム疫学研究に活用できるゲノム医学・疫学的原理や方法論、また臨床研
究への応用等について受講学生に学習し理解してもらうことを目標としている。対象は修士２回生であり、2014年前期から開始した。「予防医学の時代」と言われる21世紀医療の中でゲノム解析の果たす役割や今後のゲノム医学のあるべき姿を、講義とディスカッションを通して理解を深めた。本年度のプログラムでは以下の内容にて講義を構成した。
（１）ゲノム解読によって派生したさまざまな新しい研究領域を学び、その応用としての新規の医療技術について（２）医学およびゲノム研究の重要性について（３）コホートデザインやケースコントロール研究について、更にそれぞれの利点と限界について（４）ゲノム医学研究の推進のための最新技術に関わる基礎知識（５）バイオインフォマティクス、プロテオミクスやWeb上の データベース利用法

13. 基礎数学
担当者 ： 木下 武彦 特定講師（LIMS）
本講義は工学系出身の学生との連携を図るため，学部で数学を習っていない学生を主な対象とした基礎数学の習得を目標とした． 具体的には学部・一般教養レベルの微分・積分学および線形代数の概念について解説した． 微分・積分学の内容として，多変数の微分や積分の概念や具体的な計算方法，
Taylor 展開法，Fourier 級数などについて解説した． 線形代数の内容として，行列・ベクトルの性質とその演算，連立一次方程式，線形空間，行列式などについて解説した．

また，数式処理ソフトウェアの利用方法を解説した．
本講義で扱う内容は豊富なので，証明や演習の計算過程の詳細に時間を掛ける事はできなかった．
しかしながら，演習には数式処理ソフトウェアの利用を推奨したため，聴講者の正答率は高かった．
本プログラムにおける医工連携を学生レベルでも推進するため，本講義を通して受講生が最低限の数学的概念を習得する事を期待する．

14. シミュレーション概論
担当者 ： 木下 武彦 特定講師（LIMS）
本講義では自然現象や社会現象に対するシミュレーション手法を学習した．

シミュレーションの手順

は主に以下の3つから成る．
1: モデル化：考察の対象となる現象を記述する微分方程式を導出する．
2: 求解：無次元化した方程式を導出し，その解を求める．
3: 可視化：解の可視化および解の性質を考察する．

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微分方程式の導出には適切な次元を持つ変数を割り当て，それらの変数間のみたす関係式を導く事が重要となる．また，次元解析を行い，導かれた微分方程式が正しい次元を持つ事を確認しなければならない． 無次元化は微分方程式の次元を無次元量にする事と同時に，一般性を失うことなくパラメータを減らす変数変換である． 講義ではこれらの点を強調して説明したため，聴講者の理解度は比較的高かった．
講義では数式処理ソフトウェアを利用して微分方程式を解く方法を紹介した．

微分方程式が解析的に解けない物に対し，数値解法として Euler 法，Runge-Kutta 法，Dormand-Prince 法を解説した． 本講義では数式処理および数値計算ソフトウェアとして Python を利用した． 聴講者にはプログラミング未経
験者も含まれていたため，Python の基本的な使い方から行列操作，分岐，反復，関数定義，可視化，ア
ニメーションの解説を行った． 数値計算には Python のモジュールを利用したため，聴講者のプログラムの出来は良かった．
講義後半では微分方程式の定性的理論と近似解の誤差解析を行った． 特に，平衡点の安定性および分岐定理を紹介した． また，常微分方程式の解に対する精度保証付き数値計算法を述べた．

15. 医療経済論
担当者 ： 後藤励 特定准教授（白眉センター、経済学研究科）

富塚 太郎 特定講師（LIMS)
生命や医療に関する技術革新は、健康の改善や新しい産業の創出を通して社会の厚生の改善に結びつく可能性を持っている。医療制度は、先進国では多かれ少なかれ社会保険料や税といった公的資金が財源となっている。そのため、個々の技術の費用と健康改善に対する効果を示すことが求められている。一方、経済全体を見ると技術の伝搬や産業の創出が経済成長にどのような影響を与えるかが注目される。
医療経済論では、まず医療を取り巻く現状と環境、医療供給制度や医療財政についての概説から始め、技術に関する経済評価、技術革新の経済全体に対する影響を講義形式とディスカッションを通じて理解を深めた 。本年度のプログラムでは特に重要と思われる以下の内容にて講義を構成した。
１ ．医療概説
２ ．医療需要
３ ．医療供給体制
４ ．医療財源論Ⅰ：概要
５ ．医療財源論Ⅱ：国際比較と日本
６ ．医療制度の国際比較
７ ．保険制度とインセンティブ
８ ．医療制度改革：国際比較と日本
９ ．医療技術の経済評価

4216. 低侵襲治療学
担当者 ： 上本 伸二 教授（医学研究科・肝胆膵・移植外科学）
木村剛 教授（医学研究科・循環器内科学）

宮本享 教授（医学研究科・脳神経外科学）

坂井 義治 教授（医学研究科・消化管外科学）
小川修 教授（医学研究科・泌尿器科学）

平岡 眞寛 教授（医学研究科・放射線腫瘍学・画像応用治療学）
髙折 恭一 特定准教授（LIMS）
健康長寿社会の総合医療開発において重要なテーマである低侵襲治療学に関して、以下のとおり講義および実習を、京都大学大学院医学研究科 上本伸二教授、木村剛教授、宮本享教授、坂井義治教授、小川修教授、平岡眞寛教授の協力のもと実施した。
講義については、「肝胆膵・移植外科領域における低侵襲治療（※オリエンテーションを含む）」、「消化器疾患における低侵襲外科治療」、「脳神経外科領域における低侵襲治療」、「がん高精度放射線治療について」、「循環器領域におけるカテーテル治療」、「泌尿器科領域における低侵襲治療」を、医学部 G 棟 LIMS セミナー室および医学部附属病院において行った。
実習「消化管外科腹腔鏡手術見学」では、同病院において、腹腔鏡手術シミュレーターを使用した腹腔鏡手術を模擬体験し、さらに消化管外科手術を見学した。「肝胆膵・移植外科手術見学」では、侵襲の大きな開腹手術を見学し、低侵襲手術との違いについて、受講生どうしでディスカッションを行った。その他、低侵襲治療学の各実習では、同病院にて以下のとおりの見学を行った。
「脳神経外科手術見学（脳血管内手術および神経内視鏡手術）」：脳血管内治療を見学「放射線治療計画の実践」：放射線治療のシミュレーションを体験実習「循環器内科カテーテル治療見学」：虚血性心疾患に対する血管内治療を見学「泌尿器科手術見学（ロボット支援手術）」：ロボット支援前立腺切除術を見学

43

Program-Specific Staff – Mission and Activities

In Kyoto University, Leading Graduate School Programs are managed under the auspice of the Center for the
Promotion of Interdisciplinary education and Research (C-PIER, Figure 1). In order to implement
interdisciplinary education and to instruct each student from diverse standpoints, we recruited program-specificstaff from multiple fields related to LIMS Program (Figure 2).
Lecture-Exercise-Training
Among program-specific staff, a professor, associate professors and senior lecturers gives classes andassociate professors take charge of exercises and trainings. They also prepared for new classes and exercises forthe coming academic year. Person(s) in charge of each student’s colloquiums and specific-research are arranged
according to specific backgrounds of each member. Actual activities of the staff are shown as follows.
1. Human Anatomy ------------------------------------- Kenji Ohe, Wakoto Matsuda
2. Physiology --------------------------------------------- Wakoto Matsuda, Naoko Inaba, Yasuharu Hirai
3. Medical and life support systems (Biological test and Image analysis, Rehabilitation) ----- Kengo Kondo
4. Medical and daily life support systems (Home medical care support) ------------------------- Mie Torii
5. Debate ------------------------------------------------- Christian Altmann
6. Mechanics and Dynamics, Fundamental --------- Koji Yamamoto
7. Basic Materials Chemistry -------------------------- Yu Kimura
8. Molecular Analysis of life -------------------------- Miyuki Nishi
9. Biopharmaceutics ------------------------------------ Yuriko Higuchi
10. Medical Chemistry --------------------------------- Taku Hasegawa
11. Regenerative Medicine ----------------------------- Fuminori Sato, Aki Takimoto
12. Genom Cohort Study ------------------------------- Meiko Takahashi
13. Basic mathematics ---------------------------------- Takehiko Kinoshita
14. Introduction to Numerical Simulation ----------- Takehiko Kinoshita
15. Health Economics ---------------------------------- Taro Tomizuka
16. Minimally invasive therapy ----------------------- Kyoichi Takaori
17. Medical Engineering for Society I & II :(described in the chapter on Industrial-Academic-Government Cooperation)
Mentors
Beside a supervisor in the specific research field of each student, we arranged a LIMS supervisor (professor)
and two mentors (program-specific staff) from diverse fields related to but slightly different from the specificfield. Four instructors collaborate and help the student to plan training & research theme(s) in LIMS Program.
They support and give advices to the student so that the latter can carry out her/his project. The mentors also
take charge of the pre-research to prepare for the specific research.

44

1

LIMS Unit••••
President’s
OfficePresident

Projects across departments
unit

department
unit

department unit

Executive Vice-President
for Planning

unit

Projects
beyond existing
departments

unit
cooperation

CPIER

department unit

CPIER

Univ.
HQ

unit
unit

unit

unit

unit

Human resources
development

Exploration officeInterdisciplinary
fellows2

department

・ ・・Industry
Government

Program-Specific Staff

45

Actual Activities
1. Human Anatomy
Instructor: Masatoshi Hagiwara (Professor, Dept. Anatomy and Developmental Biology)
Takeshi Kaneko (Professor, Dept. of Morphological Brain Science)
Shigeto Yamada (Professor, Graduate School of Human Health Sciences)
Tomoki Aoyama (Associate Professor, Graduate School of Human Health Sciences)
Kenji Ohe (Program-Specific Lecturer, LIMS)
Wakoto Matsuda (Program-Specific Lecturer, LIMS)
The human anatomy course is a basic subject for the second grade students of LIMS. We have considered
important to teach the musculoskeletal system and kinesiology in detail, which will become essential
knowledge in coping with the unprecedented aging society. The students will apply human anatomy tostructure-movement coordination, which is essential for medico-engineering collaboration. This year, wehave distributed handouts and asked the students to hand in reports about the fundamentals of humananatomy. During practice, the students have learned the three-dimensional arrangement of the human bodyby touching the cadaver, studying virtual pictures and plastic models. An important feature of this programis to have the LIMS students experience human anatomy in a similar way as medical students do.

2. Physiology
Instructor: Harunori Ohmori (Professor, Graduate School of Medicine/Faculty of Medicine)
Kenji Kawano (Professor, Graduate School of Medicine/Faculty of Medicine)
Takeshi Kaneko (Professor, Graduate School of Medicine/Faculty of Medicine)
Wakoto Matsuda (Program-Specific Senior Lecturer, LIMS)
Naoko Inaba (Program-Specific Assistant Professor, LIMS)
Yasuharu Hirai (Program-Specific Assistant Professor, LIMS)
The lecture course Physiology was provided as the compulsory course to the first year LIMS students from
September to December. The course is organized to give the minimum essential knowledge to those who do
not have medical background. Knowledge in human physiology is fundamental for understanding of themechanisms how human can live, and should be the background to learn further the other field of medical
sciences in the LIMS program. Accordingly, the Physiology lecture course is organized in the following
topics:1. homeostasis; its concept and examples,
2. fundamentals of neural activities; ion channels, membrane excitability, action potential, and synapse,
3. structure and function of the brain, and sensory reception and motor coordination,
4. cardiovascular system and pulmonary system.
To check and promote the students’ understanding, a writing assignment was given after each topic.
In March, we provided some practice of physiology for LIMS students, using the setups, which are also46

used in the practice for medical students. The practice is intended to teach students how to conduct
experiments and analyze data of physiology.

3. Medical and life support systems (Biological test and Image analysis, Rehabilitation)
Instructor: Tsuyoshi Shiina (Professor, Graduate School of Medicine)
Kuniaki Saito (Professor, Graduate School of Medicine)
Naozo Sugimoto (Professor, Graduate School of Medicine)
Soichi Adachi (Professor, Graduate School of Medicine)
Hiroshi Kuroki (Professor, Graduate School of Medicine)
Hiroshi Yamane (Professor, Graduate School of Medicine)
Toshiko Futaki (Professor, Graduate School of Medicine)
Toshihiro Kato (Associate Professor, Graduate School of Medicine)
Hidefumi Hiramatsu (Lecturer, Graduate School of Medicine)
Kengo Kondo (Program-Specific Assistant Professor, LIMS)
This course aimed to introduce advanced medical equipment used in hospitals and in a home-care setting,and health care support and rehabilitation in hospitals and nursing-care facility through lectures and seminars.
Students studied overview and understood the importance of integration of medical, welfare and home-care.
Moreover they discussed the demand of medical engineering which develops integrated medical systems
based on requirements in medical practice beyond conventional medicine-engineering collaboration scheme.
[Biological test and Image analysis]
1. Lecture
1.1 Apr.11, 2014

Pathological conditionan alysis based on omics

・Role of clinical examination in individualized medicine: preemptive medicine and companion diagnostics
・Pathophysiological analysis by omics for new diagnostic agent development: proteomics, metabolomics, genomics
・IDO: drug development and diagnostic agent development
1.2 Apr. 11, 2013

Medical image equipment

・Morphology images of organs: chest X-ray, radiographic visualization of the stomach, X-rays of thedigestive tract, coronary X-ray angiography, mammography, X-ray CT of the head, X-ray 3D CT of theheart, and full-body MRI.
・Various images of head (morphology and function): X-ray CT, MRI, SPECT, PET, fMRI, cerebral
angiography, MRA, and NIRS.
・Visualization of morphology and function by light and ultrasound: thermography, fundus photograph,fundus OCT, endoscope (stomach), endoscope (large intestine), capsule endoscope, endoscope (vessel),endoscopic ultrasound, and ultrasound (abdomen).
1.3 Apr. 15, 2014

SeminarA biomedical testing method, flow cytometry, was introduced. First,
principle and applications were lectured. Then, as a practice, blood
samples were analyzed using flow cytometer. The results of the samples
with and without fluorescence-labeled antibodies were compared. It
made the students understood how it works and what are observed.

47

1.4 Apr. 22, 2014

Extramural seminar

LIMS students visited a developing manufacturer of medical
imagingequipmentandtestingequipment,

Shimadzu

Corporation, and observed analyzing devices and medical
imaging devices. They learned about the devices, theirdevelopments and their applications by receiving explanationsof the devices, interviewing about development, and touchingthem. They also learned how to fabricate medical equipment byobserving the assembling processes of X-ray imaging devices.
[Rehabilitation]
1. Lecture
1.1 May 13, 2014

Physical therapy

・What is required ?
・Recognition of current situation: population aging rate, disorders, diseases, and average length of hospital stay・Recovery rehabilitation unit
・Rehabilitation not completed within hospital: the importance of chronic rehabilitation
・Etymology of rehabilitation
・Targets and areas of physical therapy
・New era of developing equipment
1.2 May 16, 2014

Occupational therapy

・Introduction: etymology, characteristics, functions, targets, means, and areas
・Occupation used in occupational therapy
・History, the number of occupational therapist in Japan and the world, and the number of schools
・Classification of occupational therapy
・Occupational therapy in psychiatry・Occupational therapy in physical dysfunction
・Examples of disorders and rehabilitations
2. May 20, 2014, May 30, 2014

SeminarStudents improved the understanding of rehabilitation by attending physical therapy and occupational
therapy at rehabilitation unit of Kyoto University Hospital with physical therapist and occupational
therapist, respectively.

4. Medical and daily life support systems (Home medical care support)
Instructor: Hidenori Arai (Professor, Graduate School of Medicine and Faculty of Medicine)
Mie Torii (Program-Specific Assistant Professor, LIMS)
Grade: MC1
Credit: 2
Lecture Forms: Lecture and field trip
In Japan, one in four people are over 65, and we are under pressure to take increased measures to deal withwelfare, nursing and medical care needs. The Ministry of Health, Labor and Welfare recommends regional
comprehensive support in which older adults can spend the terminal stage of their lives in their own homes and48

neighborhoods rather than staying in long-term care facilities. To enhance this support, we need strengthening of
coordination with welfare and medical care, full care services, promotion of preventive care, and elderly accessfeatures in the home. This course provides the lectures on basic characteristics of elderly patient life and welfare
law and policy, and also provides field trips to welfare facilities. We will focus on the present condition of older
adults and aim to promote dialogue and consideration how to advance medical support systems and equipment.
April. 18th, 2014

Lecture (1)A. Background of an aging society: The trend in Japan and other countries
B. The characteristics of older adults:
Progression of physical/ physiological and mental/ social function
C. Diseases associated with older adults
April. 25th, 2014

Lecture (2)D. Elderly welfare law and policy:
Outline, background and service content of Long-Term Care Insurance Act
May. 2nd, 2014

Field trip (1)A. Rehabilitation day care center
This center is a novel day care center which specializes in living rehabilitation, using purpose-built machinery
introduced from countries with developed welfare service infrastructures. This center provides older adults
with physical assessment and muscular workout programs supervised by physiotherapists. In order tounderstand the importance of prevention and rehabilitation, our students acted as subjects in the program.
May. 9nd, 2014

Field trip (2)B. Welfare facilities
These composite facilities consist of 1) intensive-care nursing homes; 2) short-term admission for daily
lifelong term-care facilities; 3) day-care centers. Local families can use facilities within the day-care centers,
designed to foster intergenerational social communication with elderly patients and local families. In orderto understand varied care levels, types of healthcare cooperation, life support services and regional
exchange, our students observed older adults who lived in various types of facilities.
C. Community General Support Center, Hemodialysis Center, Acupuncture and Moxibustion Clinic
A Community General Support Center is a public consultation center in which care is provided for frail
elderly, and welfare, health and medical services are provided by public health nurses and social workers. To
understand cooperation with medical and welfare services, our students visited the center and attended alecture on how their support is provided. They also visited a hemodialysis center, acupuncture andmoxibustion clinic to understand life styles of home care patients.

5. Debate
Instructor: Christian F. Altmann, Program-Specific Associate Professor, Graduate School of Medicine
The English Debate course and practice was held in 2014 as a weekly course with the aim to a) improve
the students’ ability to form and express their opinions in English, in front of an audience with different
scientific backgrounds and nationalities, b) improve their ability to respond to questions and to defend theiropinion, and c) improve their ability to refute others' arguments.

49

The first year students of the master’s course focused on basic argumentation skills in the summer term of
2014. More specifically, they engaged in discussions of the use of animal models in biomedical research, thehealth care system in the U.S.A. and worldwide, and the construction of a nuclear power plant, among othertopics. In the winter term, students practiced giving presentations of scientific ideas, business and policy
proposals. For example, students proposed ideas like check-lists for surgeries, structure-guided drug design,
simulation of cellular signaling networks or presented research related to the coevolution of humans andmalaria hosts, or self-assembling DNA-bricks.
The second year students of the master’s course began with presentation practices in the summer term,talking for example about the regulation of host obesity by gut microbiota, DNA-methylation as a marker fortissue age, or proposing how the elderly could be involved in our children’s education. In the winter term,
teams of two students proposed an idea which was discussed in a meeting, which – depending on the topic– simulated a science grant committee, a company board or a political TV discussion. Exemplary topics were
the introduction of financial education early in elementary school, an automated insulin dispenser coupled toan implanted blood glucose meter, and the use of induced pluripotent stem cells for skin rejuvenation.

6. Mechanics and Dynamics, Fundamental
Instructor: Kazuyoshi Nakabe (Professor, Dept. of Mechanical Engineering and Science)
Taiji Adachi (Professor, Institute for Frontier Medical Science)
Koji Yamamoto (Program-Specific Associate Professor, LIMS)
The course is designed to introduce mechanical engineering, mainly four fundamental dynamics such as
Mechanical dynamics, Dynamics for material and structure, Fluid dynamics and Thermodynamics, tostudents who do not have a background of mechanical engineering. The primary aim is to acquire and refineknowledge of mechanical engineering necessary for developing novel devices or measuring systems in the
medico-engineering field. In this year, three hours lecture was given every Tuesday during two months (July& August) for two students. In the first half of this course, those dynamics were explained with the concept
of continuum physics, which can help students understand the relation between equations of motion or
governing equations and real phenomena. In the lecture, we focused on the physical implications ofequations describing each dynamics and theoretically expounded common physical phenomena, such as
movement, deformation of objects with mass and shape, and flow of gas or liquid. In the second half, we
introduced how those principles of mechanics have been applied to real-world equipments and systems, andalso explained about the latest mechanical engineering technologies used in the field of medical or welfare
engineering. Practical training of this course for second-year master's students was held as part of the class:
Biomaterials and Artificial Organs.

7. Basic Materials Chemistry
Instructor: Teruyuki Kondo (Professor, Advanced Biomedical Engineering Research Unit, C-PiER)
Yu Kimura (Program-Specific Associate Professor, LIMS)

50

In academic year 2014, an exercise of organic chemistry was performed initially. This exercise wasintended to evaluate the actual skills of students. Based on the evaluation, the review about basic organic
chemistry was lectured with detailed accounts of the exercise. The review especially emphasized
explanations about presuming reaction mechanisms, processes to develop the reaction, and synthesis
strategy, especially including retrosynthetic analysis. Then, characteristics and synthetic routes of medicines
such as sulfa drug and indinavir were lectured from the viewpoint of pharmacophore, structure-property
relationship, mechanism of action and their biodistribution. In contrast, biomaterials as a large bulk material
for clinical use have many functional moieties and characteristic properties, such as bioavailability,
biocompatibility, antithrombogeneity, or other bioactivities, the lecture summarized these properties withthe explanation in molecular level. Also, we put emphasis on understanding not only of basic requirements
as biomaterial, but also of the reason why the chemical composition was chosen to use as a biomaterial. The
knowledge would be helpful to design novel materials based on a demand in fruitful healthy-longevity
society. Through the submitting report after the course, we evaluated students on the proficiency andutilizing ability of obtained knowledge. In addition, a practice inimaging chemical probes on mouse was executed for the first time inthis academic year (see photo). Together with students, pigment
molecules as a probe were injected via tail vein of mice, and the
distribution was observed with 3-D photoacoustic CT scanner andfluorescence camera-TV monitor. These experiences would be helpful
to prepare further anatomy and physiology courses.

8. Molecular Analysis of life
Instructor: Yasuo Mori (Professor, Graduate School of Engineering, Department ofSynthetic Chemistry and Biological Chemistry)
Miyuki Nishi (Program-Specific Associate Professor, LIMS)
To understand analytical methods that clarify roles of molecules in controlling biological functions,fundamenta ltechniques and knowledge will be acquired in this course. Specifically, we will focus on
structures of genes and proteins, analyses of dynamics of proteins and 2nd messengers. The target of thiscourse includes those students who are not familiar to living organisms as their subjects ofexperiments/studies. The course also provides an opportunity to prepare for the later advanced programcurriculum of the leading program.
1. Orientation
2. Analysis of genes and determination of DNA sequences
3. Analysis of Proteins
4. Second messenger and thermosensor
5. Cell sorting
6. Presentation and Discussion

51

9. Biopharmaceutics
Instructor: Kazuhisa Nakayama (Professor, Graduate School of Pharmaceutical Sciences)
Yoshinobu Takakura (Professor, Graduate School of Pharmaceutical Sciences)
Mitsuru Hashida (Professor, Graduate School of Pharmaceutical Sciences)
Yuriko Higuchi (Program-Specific Senior Lecturer, LIMS)
This lecture toward “Biopharmaceutics” will be provided to 2nd-graders. In this lecture, we introduced theanatomical and physiological characteristics of tissues in the body to understand drug disposition processes,
including absorption, distribution, metabolism, and excretion. Then, we explained the mechanisms of drug
disposition in each process, and provide the basic concept and its application example of drug delivery
system (DDS). Short presentation in English by students helped further understanding of lectures.
- Drug absorption after local injection, and factors affecting it- Anatomical and physiological characteristics of the skin and transdermal absorption of drugs- Anatomical and physiological characteristics of the gastrointestinal tract and gastrointestinal absorptionof drugs- Rectal, pulmonary and nasal absorption of drugs- Factors affecting drug distribution in each tissue- Structure and functions of blood-brain barrier, blood-cerebrospinal fluid barrier and placental barrier,and drug distribution into brain and fetus thorough the barriers-Anatomical and physiological characteristics of the kidney and renal excretion mechanisms of drugs-Biliary excretion and enterohepatic circulation of drugs-Drug metabolism and drug-metabolizing enzymes-Drug/drug interactions-Basic of clinical pharmacokinetics-Drug delivery systems for major protein drugs and nucleic acid drugs and those for cell therapy

10. Medical Chemistry
Instructor: Dai Watanabe (Professor, Dept. of Biological Sciences)
Motoko Yanagita (Professor, Dept. of Nephrology)
Shigekazu Nagata (Professor, Dept. of Medical Chemistry)
Nagahiro Minato (Professor, Dept. of Immunology and Cell Biology)
Makoto Noda (Professor, Dept. of Molecular Oncology)
Taku Hasegawa (Program-Specific Assistant Professor, LIMS)
The aim of this course is that LIMS students, especially those with the background in engineering, acquire
knowledge in the common diseases in the modern society. With the help of the faculty in Graduate Schoolof Medicine, the biochemical and molecular biological mechanisms for diseases, as well as the current
treatment for diseases, are explained and discussed. In this course, the students are expected to acquire theknowledge that the second- or third-grade medical students learn; the lectures cover from the basics inbiochemistry and molecular biology to the mechanism of diseases, especially focused on the disease havingsocial significance, such as diabetes or cancer. In this academic year, the lectures were held in April andMay, aimed at M1 and M2 students.

52

The LIMS students with the engineering background are expected to utilize the knowledge obtainedin this course during the future development of new treatments for diseases or medical instruments.
Furthermore, even for the students with the biology background, this course provides the great
opportunity to study biochemistry and molecular biology from the perspective of the diseases
commonly occurring in the society.

11. Regenerative Medicine
Instructor: Hiroo Iwata (Professor, Institute for Frontier Medical Sciences)
Yuji Hiraki (Professor, Institute for Frontier Medical Sciences)
Atsuko Sehara (Professor, Institute for Frontier Medical Sciences)
Yasuhiko Tabata (Professor, Institute for Frontier Medical Sciences)
Taiji Adachi (Professor, Institute for Frontier Medical Sciences)
Hirofumi Suemori (Associate Professor, Institute for Frontier Medical Sciences)
Masaya Yamamoto (Associate Professor, Institute for Frontier Medical Sciences)
Fuminori Sato (Program-Specific Assistant Professor,LIMS)
Aki Takimoto (Program-Specific Assistant Professor,LIMS)
The rapid advances in stem cell biology including iPS cell research and its clinical applications make it
more important to comprehensively understand regenerative medicine in the various field of medicine.
Institute for Frontier Medical Sciences focuses on the basic and application studies on regenerative medicine
including stem cell biology, developmental biology, and tissue engineering. This course started in October,
2014, for the first and second year LIMS students, and provided lectures on the following latest topics:• History and recent advance of pluripotent stem cell research. Use of human PSCs for cell transplantation therapy.
• Cellular Differentiation and Stem Cells (I), (II)• Hard tissue development and regeneration (I) ECM, (II) Growth & differentiation, (III) Connections of building blocks• Cell Lego
• Definition of biomaterials and their applications to medical devises and drug delivery system (DDS)• Regenerative medicine from the viewpoint of biomaterials – Regenerative research and regenerative therapy –• The importance of material sciences in hard tissue regenerative medicine.
• In vitro fabrication of tissue-like constructs and their applications• Nanotechnologies for regenerative medicine• Modeling and simulation of bone regeneration/remodeling and their application to scaffold design• Modeling and simulation of multicellular dynamics in tissue morphogenesis
Through the lectures concerning stem cells, cellulardifferentiation, organogenesis, and biomaterials, we madea special effort to encourage students to find a systematicconnection between basic and clinical studies onregenerative medicine. This course also provided a lecture
on biomechanics to help students understand themechanical aspects of developmental phenomenon andlocomotive organs, which are latest research topics indevelopmental biology and regenerative medicine.

5312. Genome Cohort Study
Instructor: Meiko Takahashi (Program-Specific Senior Lecturer, LIMS)“Genome Cohort Studies” provides an intensive introduction to genomic epidemiology and methods forstudents intending to engage in, collaborate in, or interpret the results of genomic and epidemiologic
research. This course is available for second year Master’s degree students, and was started in April 2014.
Through lectures and group discussions, students will be able to understand the essential roles genomic
analyses will play in 21st Century medicine - the era of "preventive medicine". The course covers thefollowing topics:(1) Various research fields and the novel techniques developed that have emerged in the years sincecompletion of the Human Genome Project.
(2) Understand the importance of medicine and genomic research.
(3) Understand what a cohort design is, comprehend the differences between cohorts and case-control
analyses, and appreciate the strengths and weaknesses of the various types of analyses.
(4) Acquire basic knowledge of the latest technologies used in genomic medicine.
(5) Learn the different techniques used in bioinformatics and proteomics, as well as how to handle
web-based public databases.

13. Basic mathematics
Instructor: Takehiko Kinoshita (Program-Specific Senior Lecturer, LIMS)
Since the medical students and cooperation with the engineering students are attempted, learning of thebasic mathematics for the students who is not learning mathematics in undergraduates was a target.
Specifically, this course introduced students to differential and integral calculus and linear algebra at thelevel of undergraduates. As for Calculus, we explained the concepts of differentiation and integration forfunctions of many variables, some methods for calculation, Taylor series, Fourier series, etc. In addition, as
for linear algebra, we explained the properties of vectors and matrices and their operations, simultaneous
linear equations, linear spaces, determinant, etc. Moreover, we learned how to use the formula manipulation
system in Python.
Since this course has the very abundant topics, it was not possible to spend time on the detail of calculation
process for proofs or practice problems. However, the correct answer rate of audiences was high because
using the formula manipulation system was recommended in practice problems.
We expect that audiences acquire minimum concepts of mathematics through this course to promote
medicine-engineering collaboration at the student level.

5414. Introduction to Numerical Simulation
Instructor: Takehiko Kinoshita (Program-Specific Senior Lecturer, LIMS)
This course introduced methods of numerical simulations for various natural or social phenomena.
The process of simulation is three-fold:
1: Modeling: derive a differential equation which models the phenomenon under consideration.
2: Solving: Nondimensionalize the equations and solve them.
3: Visualizing: visualize the solution and analyze its properties.
It is important for modeling to recognize the variables with appropriate dimensions and to derive a
relationship between them. It is also important to verify whether the derived equations have appropriate
dimensions. Nondimensionalization enables us to reduce the number of parameters without loss ofgenerality as well as to obtain equations for nondimensional quantities. I emphasized these three points inthe course, and the students achieved a comprehensive understanding about them.
I taught how to use formula manipulation system in order to solve ordinary differential equations (ODE).
Numerical simulation is necessary for analyzing ODEs which are not solvable by quadrature. I taught somenumerical methods, the Euler method, the Runge-Kutta method, and the Dormand-Prince method, to solve
ODEs.
Python was adopted as the formula manipulation system and the numerical computation software in thiscourse. I taught how to use Python: matrix operations, conditional expressions, loop, user-defined functions,visualization, and animation. Since we used the Python module to analytically or numerically solve ODEs,
the source cords of students are well-made.
In the last part of the course, I taught the qualitative theory of ordinary differential equations and the error
analysis of numerical solutions. Especially, I introduced the stability and bifurcation theory of equilibria.
Moreover, I explained the validated computational method for solutions of ordinary differential system.

15. Health Economics
Instructor: Rei Goto (Program-Specific Associate Professor, Hakubi Center, Department of Economics)
Taro Tomizuka (Program-Specific Senior Lecturer, LIMS)
Innovations in health and healthcare can realize the welfare gain through the improvement of peoples'
health and the development of new industry. In developed countries, healthcare system is financed mainly
by collective public funds like social insurance and tax. Therefore, it is important to assess costs andeffectiveness of health technology from societal perspectives. From industrial perspectives, the impacts ofinnovations on economic growth are highly counted.
In this course, students acquired knowledge of the strengths and weaknesses of evaluations methods ofhealth technology, as well as the outline of the systems of financing and provision of healthcare.

55

This course consisted of following topics:
1. Overview and context of health and health care
2. The demand for health care
3. The supply of health care
4. Health care financing 1: overview
5. Health care financing 2: International comparison and Japan’s financing
6. International comparison of health care system
7. Health care insurance and incentives
8. Health care reforms: International comparison and Japan’s case
9. Principles of economic evaluations in health care

16. Minimally invasive therapy
Instructor: Shinji Uemoto(Professor, Department of Hepato-Biliary-Pancreatic Surgery and Transplantation)
Takeshi Kimura (Professor, Department of Cardiovascular Medicine)
Yoshiharu Sakai (Professor, Department of Gastrointestinal Surgery)
Osamu Ogawa (Professor, Department of Urology)
Masahiro Hiraoka (Professor, Department of Radiation oncology)
Kyoichi Takaori (Program-Specific Associate Professor, LIMS)
Lectures and practical seminars about minimally invasive therapies have been given under supervisions byProfessors Takeshi Kimura, Susumu Miyamoto, Yoshiharu Sakai, Shinji Uemoto, Osamu Ogawa, andMasahiro Ogawa, Kyoto University Graduate School of Medicine.
Lectures included “Minimally invasive surgery in hepato-biliary-pancreatic surgery and transplantation(orientation inclusive)”, “Minimally invasive surgery for digestive diseases”, “Minimally invasive
therapiesin neurosurgery”, “High precision radiation therapy for cancer”, “Intravascular catheter treatments
in cardiovascular medicine”, “Minimally invasive surgery in urology” and these lectures were given at theseminar room of LIMS in the G building of Medical Faculty or at the Kyoto University Hospital.
The attendants experienced laparoscopic surgery by themselves with a simulator at the Kyoto University
Hospital during the course of “Minimally invasive surgery for digestive diseases” and observed proceduresof gastrointestinal surgery at the operation theater of the Kyoto University Hospital later on. Besides, theattendants of the course observed conventional open surgery associated with significant invasiveness during
the “Surgery in hepato-biliary-pancreatic surgery and transplantation” and had a group discussion about thecomparison between the conventional surgery and minimally invasive surgery subsequently. Moreover,other courses consisted of following contents.
“Minimally invasive therapies in neurosurgery”: observation of intravascular therapies for brain vasculardiseases.
“High precision radiation therapy for cancer”: simulation of radiation therapy planning.
“Intravascular catheter treatments in cardiovascular medicine”: observation of intravascular therapies forischemic heart diseases.
“Minimally invasive surgery in urology”: observation of a robotic prostatectomy.

56

設備備品 Equipment

No.
No.
1
1

2
2

ᖹᡂ㻞㻢ᖺᗘ䚷䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮୺せタഛഛရ䛾タ⨨┠ⓗᖹᡂ㻞㻢ᖺᗘ䚷䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮୺せタഛഛရ䛾タ⨨┠ⓗ
ྡ䚷䚷⛠
タ⨨┠ⓗ
ྡ䚷䚷⛠
ᾮయ䝝䞁䝗䝸䞁䜾⮬ື໬⿦⨨୍ᘧᾮయ䝝䞁䝗䝸䞁䜾⮬ື໬⿦⨨୍ᘧ䠓䠰䠩䠮䠥⿦⨨⏝䛂䠏䡎䡀䚷䠫䡎䡀䡁䡎䚷䝅䝭䞁䜾䝅䝇䝔䝮䛃䚷୍ᘧ䠓䠰䠩䠮䠥⿦⨨⏝䛂䠏䡎䡀䚷䠫䡎䡀䡁䡎䚷䝅䝭䞁䜾䝅䝇䝔
䝮䛃䚷୍ᘧ

3

ග㡢㡪㻌㻯㼀㻌䝇䜻䝱䝘䞊䚷୍ᘧ3ග㡢㡪㻌㻯㼀㻌䝇䜻䝱䝘䞊䚷୍ᘧ

No.
No.
1
1

2
2

タ⨨┠ⓗ
〇⸆௻ᴗ䛻䛚䛡䜛๰⸆䛾⌧ሙ䛷䛿኱つᶍゎᯒ⏝䝽䞊䜽䝇䝔䞊䝅䝵䞁䛜᪥ᖖⓗ䛻⾜䜟䜜䛶䛚䜚䚸䜰䜹䝕䝭䜰䛷䜒኱つᶍゎᯒ⏝䝽䞊䜽䝇䝔䞊䝅䝵䞁䜢౑⏝䛩䜛ᚲせᛶ䛜㧗䜎䛳䛶䛔䜛䛜䚸㏻
ᖖ䛾኱Ꮫ㝔ᩍ⫱䛷䛿䜋䛸䜣䛹᥋䛩䜛ᶵ఍䛜䛺䛔䚹䝞䜲䜸䝔䝑䜽䝁䞁䝟䜽䝖䝽䞊䜽䝇䝔䞊䝅䝵䞁〇⸆௻ᴗ䛻䛚䛡䜛๰⸆䛾⌧ሙ䛷䛿኱つᶍゎᯒ⏝䝽䞊䜽䝇䝔䞊䝅䝵䞁䛜᪥ᖖⓗ䛻⾜䜟䜜䛶䛚㻱㻰㻾㻙㻟㻤㻠㻿㼄䛿䚸ᵝ䚻䛺䝥䝷䝑䝖䝣䜷䞊䝮䛻ᑐᛂ䛧䛯኱つᶍ䛺໬ྜ≀䝇䜽䝸䞊䝙䞁䜾䜔⥙⨶ⓗ䜚䚸䜰䜹䝕䝭䜰䛷䜒኱つᶍゎᯒ⏝䝽䞊䜽䝇䝔䞊䝅䝵䞁䜢౑⏝䛩䜛ᚲせᛶ䛜㧗䜎䛳䛶䛔䜛䛜䚸㏻
㼟㼕㻾㻺㻭ゎᯒ䛺䛹䜢ྍ⬟䛸䛩䜛ᶵჾ䛷䛒䜛䚹䛭䛣䛷䚸䛣䛾ᶵჾ䜢་Ꮫ◊✲ᨭ᥼䝉䞁䝍䞊䛻ᑟධᖖ䛾኱Ꮫ㝔ᩍ⫱䛷䛿䜋䛸䜣䛹᥋䛩䜛ᶵ఍䛜䛺䛔䚹䝞䜲䜸䝔䝑䜽䝁䞁䝟䜽䝖䝽䞊䜽䝇䝔䞊䝅䝵䞁䛧䚸ཎ⌮䜔฼⏝ἲ᪉䜢ᙜ䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮䛾ᒚಟ⏕䛻ᩍᤵ䛩䜛䛣䛸䛻䜘䜚䚸䜰䜹䝕䝭䜰㻱㻰㻾㻙㻟㻤㻠㻿㼄䛿䚸ᵝ䚻䛺䝥䝷䝑䝖䝣䜷䞊䝮䛻ᑐᛂ䛧䛯኱つᶍ䛺໬ྜ≀䝇䜽䝸䞊䝙䞁䜾䜔⥙⨶ⓗ๰⸆䜔኱つᶍゎᯒ➼䜢ᢸ䛖ேᮦ䜢⫱䛶䜛䚹㼟㼕㻾㻺㻭ゎᯒ䛺䛹䜢ྍ⬟䛸䛩䜛ᶵჾ䛷䛒䜛䚹䛭䛣䛷䚸䛣䛾ᶵჾ䜢་Ꮫ◊✲ᨭ᥼䝉䞁䝍䞊䛻ᑟධ䛧䚸ཎ⌮䜔฼⏝ἲ᪉䜢ᙜ䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮䛾ᒚಟ⏕䛻ᩍᤵ䛩䜛䛣䛸䛻䜘䜚䚸䜰䜹䝕䝭䜰๰⸆䜔኱つᶍゎᯒ➼䜢ᢸ䛖ேᮦ䜢⫱䛶䜛䚹⌧ᅾᑟධ䛥䜜䛶䛔䜛䠓䝔䝇䝷㻹㻾㻵䠄㏻ᖖ䛿䚸䠏䝔䝇䝷䠅䛿䚸ୡ⏺䛷䠑䠌ྎ⛬ᗘ䛧䛛䛺䛟䚸ᅜෆ䛷䜒䚸኱Ꮫ㝔䛾ᐇ⩦䛺䛹䛻౑⏝䛥䜜䜛᪋タ䛿䛺䛔䛯䜑䚸䠓䝔䝇䝷㻹㻾㻵䛾᧜ീ䜢ぢᏛ䚸ᐇ⩦䛩䜛䛣䛸䛿䚸኱ኚ኱䛝䛺⤒㦂䛻䛺䜛䛸⪃䛘䜙䜜䜛䚹ᮏ⿦⨨䛾⏬ീᛶ⬟ྥୖ䛻ᐤ୚䛩䜛䛂㧗ᛶ⬟㻹㻾㻵⌧ᅾᑟධ䛥䜜䛶䛔䜛䠓䝔䝇䝷㻹㻾㻵䠄㏻ᖖ䛿䚸䠏䝔䝇䝷䠅䛿䚸ୡ⏺䛷䠑䠌ྎ⛬ᗘ䛧䛛䛺䛟䚸ᅜෆ䛷᧜ീ䝁䜲䝹䛺䜙䜃䛻࿘㎶⿦⨨䛃䛾㉎ධ䛻ண⟬䜢᣺䜚䛛䛘䜛䛣䛸䛿䚸䛣䜜䛛䜙䛾᪂䛧䛔་⒪⿦
䜒䚸኱Ꮫ㝔䛾ᐇ⩦䛺䛹䛻౑⏝䛥䜜䜛᪋タ䛿䛺䛔䛯䜑䚸䠓䝔䝇䝷㻹㻾㻵䛾᧜ീ䜢ぢᏛ䚸ᐇ⩦䛩䜛䛣⨨㛤Ⓨ䛾⌮ゎ䛻᭷⏝䛷䛒䜛䚹䛸䛿䚸኱ኚ኱䛝䛺⤒㦂䛻䛺䜛䛸⪃䛘䜙䜜䜛䚹ᮏ⿦⨨䛾⏬ീᛶ⬟ྥୖ䛻ᐤ୚䛩䜛䛂㧗ᛶ⬟㻹㻾㻵᧜ീ䝁䜲䝹䛺䜙䜃䛻࿘㎶⿦⨨䛃䛾㉎ධ䛻ண⟬䜢᣺䜚䛛䛘䜛䛣䛸䛿䚸䛣䜜䛛䜙䛾᪂䛧䛔་⒪⿦
⨨㛤Ⓨ䛾⌮ゎ䛻᭷⏝䛷䛒䜛䚹ᮏᶵჾ䛿䚸䛣䜜䜎䛷ᅔ㞴䛷䛒䛳䛯ᑠື≀䛾᏶඲䛺୕ḟඖග㡢㡪䜲䝯䞊䝆䞁䜾䜢⾜䛖䛯䜑䛾᭱᪂䛾䝅䝇䝔䝮䛷䛒䜛䚹䛩䛺䜟䛱䚸ᚑ᮶䛾஧ḟඖ᩿ᒙ⏬ീ䛛䜙ྜᡂ䛧䛯୕ḟඖ⏬ീᵓᡂ䛸䛿␗䛺䜚䚸ᮏᶵჾ䛷䛿䚸㧗䛔✵㛫ศゎ⬟䚸ឤᗘ䚸ᐃ㔞⢭ᗘ䚸䛺䜙䜃䛻▷᫬㛫䛷䛾୕ḟඖගᮏᶵჾ䛿䚸䛣䜜䜎䛷ᅔ㞴䛷䛒䛳䛯ᑠື≀䛾᏶඲䛺୕ḟඖග㡢㡪䜲䝯䞊䝆䞁䜾䜢⾜䛖䛯䜑䛾㡢㡪䜲䝯䞊䝆䞁䜾䛜ྍ⬟䛷䛒䜛䚹䛥䜙䛻䚸ᮏᶵჾ䛷䛿䚸㉸㡢Ἴ᳨ฟჾ䛾୍䛴䛜㉸㡢ἼⓎ᣺Ꮚ᭱᪂䛾䝅䝇䝔䝮䛷䛒䜛䚹䛩䛺䜟䛱䚸ᚑ᮶䛾஧ḟඖ᩿ᒙ⏬ീ䛛䜙ྜᡂ䛧䛯୕ḟඖ⏬ീᵓᡂ䛸䛾ᶵ⬟䜢ව䛽䛶䛚䜚䚸㉸㡢Ἴ䜲䝯䞊䝆䞁䜾䜢ྠ᫬䛻⾜䛖䛣䛸䛜䛷䛝䜛䛣䛸䛛䜙䚸ᑠື≀䛾ྛ⤌䛿␗䛺䜚䚸ᮏᶵჾ䛷䛿䚸㧗䛔✵㛫ศゎ⬟䚸ឤᗘ䚸ᐃ㔞⢭ᗘ䚸䛺䜙䜃䛻▷᫬㛫䛷䛾୕ḟඖග⧊䛻ᑐᛂ௜䛡䛧䛯୕ḟඖග㡢㡪䜲䝯䞊䝆䞁䜾䛜ྍ⬟䛷䛒䜛䚹ᚑ䛳䛶䚸䜎䛪䚸ᮏᶵჾ䜢⏝䛔䛯㡢㡪䜲䝯䞊䝆䞁䜾䛜ྍ⬟䛷䛒䜛䚹䛥䜙䛻䚸ᮏᶵჾ䛷䛿䚸㉸㡢Ἴ᳨ฟჾ䛾୍䛴䛜㉸㡢ἼⓎ᣺Ꮚㅮ⩏䠄ᮦᩱ໬Ꮫᇶ♏䠅䛻䛚䛔䛶䚸Ꮫ⏕䛻ග㡢㡪䜲䝯䞊䝆䞁䜾䛾ཎ⌮䜢⌮ゎ䞉⩦ᚓ䛥䛫䚸ḟ䛻䚸䛾ᶵ⬟䜢ව䛽䛶䛚䜚䚸㉸㡢Ἴ䜲䝯䞊䝆䞁䜾䜢ྠ᫬䛻⾜䛖䛣䛸䛜䛷䛝䜛䛣䛸䛛䜙䚸ᑠື≀䛾ྛ⤌ᐇ⩦䠄ᮦᩱ໬Ꮫᇶ♏䠅䛻䛚䛔䛶䛿䚸Ꮫ⏕⮬䜙䛜ᮏᶵჾ䜢⏝䛔䛶䚸ప౵く䛷䛾ᢸ⒴䝬䜴䝇䛾⒴⧊䛻ᑐᛂ௜䛡䛧䛯୕ḟඖග㡢㡪䜲䝯䞊䝆䞁䜾䛜ྍ⬟䛷䛒䜛䚹ᚑ䛳䛶䚸䜎䛪䚸ᮏᶵჾ䜢⏝䛔䛯㒊఩䛾⾑⟶ᐦᗘ䜔ప㓟⣲≧ែ䛾ග㡢㡪䜲䝯䞊䝆䞁䜾⏬ീ䜢ྲྀᚓ䛧䚸䛭䜜䜢ලయ౛䛸䛧䛶ගㅮ⩏䠄ᮦᩱ໬Ꮫᇶ♏䠅䛻䛚䛔䛶䚸Ꮫ⏕䛻ග㡢㡪䜲䝯䞊䝆䞁䜾䛾ཎ⌮䜢⌮ゎ䞉⩦ᚓ䛥䛫䚸ḟ䛻䚸㡢㡪䜲䝯䞊䝆䞁䜾ἲ䜢⩦⇍䛥䛫䜛䚹௨ୖ䛾ᵝ䛻䚸ᮏᶵჾ䛿䚸ḟୡ௦䛾䜲䝯䞊䝆䞁䜾ᢏ⾡䛚䜘ᐇ⩦䠄ᮦᩱ໬Ꮫᇶ♏䠅䛻䛚䛔䛶䛿䚸Ꮫ⏕⮬䜙䛜ᮏᶵჾ䜢⏝䛔䛶䚸ప౵く䛷䛾ᢸ⒴䝬䜴䝇䛾⒴䜃⿦⨨㛤Ⓨ䜢ᢸ䛖ᮏ䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮ᒚಟᏛ⏕䜈䛾ㅮ⩏䛚䜘䜃ᐇ⩦䛻᭱㐺䛷䛛䛴୙㒊఩䛾⾑⟶ᐦᗘ䜔ప㓟⣲≧ែ䛾ග㡢㡪䜲䝯䞊䝆䞁䜾⏬ീ䜢ྲྀᚓ䛧䚸䛭䜜䜢ලయ౛䛸䛧䛶ගྍḞ䛺ᶵჾ䛷䛒䜚䚸㧗ᗘ䛷䛿䛒䜛䜒䛾䛾䚸㞟୰ⓗ䛻ㅮ⩏䞉ᐇ⩦䜢⾜䛖䛣䛸䛻䜘䜚ẚ㍑ⓗ▷ᮇ㡢㡪䜲䝯䞊䝆䞁䜾ἲ䜢⩦⇍䛥䛫䜛䚹௨ୖ䛾ᵝ䛻䚸ᮏᶵჾ䛿䚸ḟୡ௦䛾䜲䝯䞊䝆䞁䜾ᢏ⾡䛚䜘㛫䛷᭱ඛ➃䛾⏕య䜲䝯䞊䝆䞁䜾ἲ䜢Ꮫ䜆䛣䛸䛜䛷䛝䜛䚹䜃⿦⨨㛤Ⓨ䜢ᢸ䛖ᮏ䝸䞊䝕䜱䞁䜾䝥䝻䜾䝷䝮ᒚಟᏛ⏕䜈䛾ㅮ⩏䛚䜘䜃ᐇ⩦䛻᭱㐺䛷䛛䛴୙ྍḞ䛺ᶵჾ䛷䛒䜚䚸㧗ᗘ䛷䛿䛒䜛䜒䛾䛾䚸㞟୰ⓗ䛻ㅮ⩏䞉ᐇ⩦䜢⾜䛖䛣䛸䛻䜘䜚ẚ㍑ⓗ▷ᮇ㛫䛷᭱ඛ➃䛾⏕య䜲䝯䞊䝆䞁䜾ἲ䜢Ꮫ䜆䛣䛸䛜䛷䛝䜛䚹

Major Equipment Installed in Academic Year 2014
Major Equipment Installed in Academic
Year 2014
Name of Equipment
Purpose of Installation
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MedicalSupportBiotech's
center andteach thestudents ofEDR-384SX
the LIMS is
Automatic simultaneous liquidcapablelargeofthischemicalor exhaustivesiRNAleaders
analyses.
programof
thehandlingprinciples
andplatforms
utilization
device.screening
In this way,
we can cultivateof We
dispensing workstationwish
to installin the Medical
Supportcenter and teach the students of the LIMS
academic
drugitdevelopment
andResearchlarge-scale
analysis.
program the principles and utilization this device. In this way, we can cultivate leaders ofacademicdevelopment
andlarge-scale
analysis.
7T MRI isdrug
installedaround 50
machinesin theworld, then it is very rare chance to inspect andName of Equipment

Three order simming system for operate the machine by the program student. Third order sim system will increase the
7T
MRI is andinstalledaroundmachinesin theworld,
thenis very rare
chance toinspect
and
7T MRI
sensitivity
accuracyfor 50
MRI,
therefore,
it willmaketheitstudents
experience
more
deeperThree order simming system for operate
the machineby the program
student.
order scientificsim system
will increase theand increase
the interesting
to the world
wideThird
high levelmachine.
7T MRI
sensitivity and accuracy for MRI, therefore, it will make the students experience more deeper
and increase
thedeviceinteresting
to the world
wide high levelphotoacoustic
scientific machine.
Thisdiagnosis
can constructthree-dimensional
images of small animals.

3

Photoacoustic CT Scanner

3

Photoacoustic CT ScannerPhotoacoustic imaging is a latest imaging modality, having many advantages of high spacialThis
diagnosis
device canthree-dimensional
photoacoustic
imagesof performances
small animals.
resolution,
sensitivity,and constructquantifiability.
No imaging device
with similarhighPhotoacoustic
imaging
is a latest
modality,
havingtransducer,
many advantagesof high spacial
exists at present.
In addition,
this imaging
device has
an ultrasoundwhich enables
to obtain
resolution,
sensitivity,
quantifiability.images
No imaging
device withInsimilarhigh
the ultrasoundimages and photoacoustic
simultaneously.
the classof performances"Basicexistsat present.
In addition,
thisstudents
device hasan about
ultrasoundtransducer,
which
to obtain
Materials
Chemistry",
the LIMS
learn
the basic
theory andtheenables
principles
oftheultrasound imaging.
images andphotoacoustic
images simultaneously.
In the classof "Basic
photoacoustic
Then,
the LIMS students
receive in vivo practicaltraining
about
Materials
Chemistry",
LIMS reagents
students tolearn
about the basic
theoryand theprinciples of
intravenous
injection ofthe
contrast
tumor-bearing
mouse,
as wellas photoacoustic
photoacoustic
imaging.
theandLIMS
students
receivein vivo practicaltraining
about forimaging of bloodvesselsThen,densitytumor
hypoxia.
Accordingly,
this device
is essential
intravenous
injectionof contrast
reagents
tumor-bearing
mouse, as well
as photoacoustic
training of the
LIMS students
who
becometothe
leaders on developmentof thenext generation
imaging ofblood vessels
densityand tumor
hypoxia. Accordingly, this device is essential formodalities
as wellas medical
equipments.
training of the LIMS students who become the leaders on development of the next generation
imaging modalities as well as medical equipments.

57

58

3.
国際連携
International Cooperation

ᖹᡂ26ᖺᗘ䚷እᅜ䛛䜙䛾ᣍ䜈䛔ᐇ⦼୍ぴẶྡ䞉ᡤᒓ䞉⫋

ᐇ᪋᪥

ᐇ᪋ෆᐜ

2014ᖺ
5᭶27䞉29᪥䚸
6᭶4䞉11䞉12᪥
2014ᖺ7᭶8᪥䡚10᪥䚸17᪥

Denis Le Bihan

1䝣䝷䞁䝇䝙䝳䞊䝻䝇䝢䞁◊✲ᡤ㉸㧗☢ሙ䠩䠮䠥◊✲䝉䞁䝍䞊ᡤ㛗

2014ᖺ10᭶2᪥䚸6᪥䚸9᪥ⱥㄒdebate䜽䝷䝇䠄≉ู䜽䝷䝇䠅

2014ᖺ11᭶20᪥䚸
27᪥䚸12᭶1᪥䚸4᪥

2015ᖺ1᭶26᪥䚸2᭶2᪥䚸9᪥

Robert L. Norton

2䜰䝯䝸䜹
Fox Rothschild, LLPᘚㆤኈ

2014ᖺ7᭶24᪥

LIMSᤵᴗ⛉┠䛂▱ⓗ㈈⏘䠃ᅜ㝿ᶆ‽໬䛃䛻ಀ䜛ㅮ⩏䛂▱㈈䛾ᅜ㝿䝝䞊䝰䝘䜲䝊䞊䝅䝵䞁䛃

2014ᖺ10᭶20᪥䡚10᭶24᪥እ㒊ホ౯䚷䛚䜘䜃䚷LIMS≉ู䝉䝭䝘䞊 "MRIHardware: Design Requirements at High Field"䚸
"Functional Brain Imaging at High Magnetic Field"

Robert Turner3䝗䜲䝒䝬䝑䜽䝇䞉䝥䝷䞁䜽ㄆ▱⚄⤒⛉Ꮫ◊✲ᡤྡ㄃ᡤ㛗William James Moody4䜰䝯䝸䜹䝽䝅䞁䝖䞁኱Ꮫ
ᩍᤵ

2014ᖺ12᭶
3᪥䞉4᪥

LIMS≉ู䝉䝭䝘䞊 "Brain Development, Plasticity,and Aging: A continuum of mechanisms (1,2)"

Nace L. Golding5䜰䝯䝸䜹䝔䜻䝃䝇኱Ꮫ䜸䞊䝇䝔䜱䞁ᰯ෸ᩍᤵMichael Hideki Myoga
6䝗䜲䝒䝬䝑䜽䝇䝥䝷䞁䜽◊✲ᡤᩍᤵ

R. Michael Burger Jr.
7

60

䜰䝯䝸䜹
䝸䞊䝝䜲኱Ꮫ
෸ᩍᤵ

2015ᖺ3᭶19᪥

LIMS≉ู䝉䝭䝘䞊 "Hearing; Physiology and aging"䠄㐃⥆ㅮ⩏䠅

Lecturers from Abroad in Academic Year 2014
Name/Title/Affiliation

Date

Purpose of visit

May 27, 29,
June 4, 11, 12,2014

Denis Le Bihan

Director
1 NeuroSpin
CEA-Saclay CenterFranceJuly 8, 10, 17,2014
October 2, 6, 9,
2014

English debate class (special class) for LIMS
Students

November 20, 27,
December 1, 4,
2014

January 26,
February 2, 9,
2015

Robert L. Norton

2 Lawyer
Fox Rothschild, LLP
USAJuly 24, 2014

Lecture entitled "International
Harmonization of IP"
for LIMS Intellectual Property & Global
Standardization Class

October 20 - 24,
2014

External evaluation for LIMS Program andtwo lectures: "MRI Hardware: Design
Requirements at High Field" and"Functional Brain Imaging at High Magnetic
Field"

December 3, 4,
2014

LIMS Special Seminar "Brain Development,
Plasticity, and Aging: A continuum of
mechanisms (1,2)"

Robert Turner

Director Emeritus
3 Max Planck Institute for
Human Cognitive and Brain Sciences
Germany

William James Moody

Professor
4 Department of Biology
Washington University
USA

Nace L. Golding

Associate Professor
5 Section of Neurobiology
University of Texas at Austin
USA

Michael Hideki Myoga

6 Research Professor
Max-Planck-Institut for Neurobiologie
Germany

March 19, 2015

LIMS Special Seminar (Lecture series)"Hearing; Physiology and aging"

R. Michael Burger Jr.

Associate Professor
7 Dept. of Biologibal Sciences
Lehigh University
USA

61

Reports for Inviting Lecturers from Abroad
1)

Hidenao Fukuyama (Professor)

Robert Turner has retired his position of Max-Planck Institute, Leipzig early 2014.
He visited Kyoto University for evaluating our program as well as giving lectures on MRI
physics. He was appointed as the reviewer of our program since our program starting, andinspected the lectures and discussed with the students.
Professor Turner is one of the leaders on MRI physics, which is very essential for building
up MRI. His lectures was somewhat difficult for the students, but might be inspired by theworld wide top level researcher. This kind of impact will be good for the young students.
He stayed in Kyoto and discussed with us on regard to future MRI.

Denis LeBihan is the director of Neurospin, where is the largest MRI research
center in Europe. He visited several times to Kyoto and did English debate with thestudents. This debate is tough for the students, because he is a strong speaker against any
issues. I think the students would have an impression that the leader of the world is toughand very difficult to persuade him/her to our opinion.

2)

Yutaka Teranishi (Professor)ࠕ▱ⓗ㈈⏘㸤ᅜ㝿ᶆ‽໬ࠖㅮ⩏ࢱ࢖ࢺࣝ㸸ࠕ▱㈈ࡢᅜ㝿ࣁ࣮ࣔࢼ࢖ࢮ࣮ࢩࣙࣥࠖ
ㅮᖌ㸸Robert L. Norton ᘚㆤኈཧຍ⪅㸸⣙ 30 ྡෆ ᐜ▱㈈࡜ᅜ㝿ᶆ‽࡟㛵ࡋ࡚ࠊ⡿ᅜࡢ஦౛ࢆඖ࡟࠾ヰࡋࢆࡋ࡚࠸ࡓࡔ࠸ࡓࠋ࡜ࡾࢃࡅࠊ
⡿ᅜ≉チἲࡀඛⓎ᫂୺⩏࠿ࡽඛฟ㢪୺⩏࡬࡜኱ࡁࡃኚ᭦ࡉࢀࡓⅬࠊࡉࡽ࡟ࠊ≉チッゴ㢖Ⓨ࡟࡜ࡶ࡞࠺⤒῭άືࡢ೵⁫ࡢᘢᐖࢆᢚไࡍࡿࡓࡵࡢᑐᛂ⟇࡞࡝ㄝ᫂ࡀ࠶ࡗ
ࡓࠋඛⓎ᫂୺⩏࡟࠾࠸࡚ࠊⓎ᫂ࡢド᫂ࡢ᰿ᣐࢆத࠺Interference ࡢᡭ⥆ࡁࡀᗫṆࡉࢀࡓࡇ࡜ࡀࠊ኱ࡁ࡞ᨵኚ࣏࢖ࣥࢺ࡛࠶ࡿ஦ࡀᣦ᦬ࡉࢀࡓࠋ
ࡲࡓ࢔࣓࡛ࣜ࢝ࡣࠊࣂ࢖࣭ࢻ࣮ࣝἲࡢ᪋⾜࠿ࡽ㸱㸮ᖺ௨ୖࡀ⤒ࡕࠊ࢔࢝ࢹ࣑࢔ࡢ
◊✲ᡂᯝ࣭ᢏ⾡⛣㌿ࡢᡂຌ౛ࡶከࡃ⵳✚ࡉࢀ࡚࠸ࡿࡀࠊࡇࢀࡽࡢ஺΅ࡢ࣏࢖ࣥࢺ࡞
࡝ࡶࠊᐇົ࡟ᦠࢃࡿᘚㆤኈࡢ⤒㦂࠿ࡽヲࡋࡃㄝ᫂ࢆࡋ࡚࠸ࡓࡔ࠸ࡓࠋ

62

3)

Harunori Ohmori (Professor)

Special lecture by Professor WJ Moody, Washington University, Seattle
December 3-4, 2014
Professor William J Moody talked about the brain development, plasticity andaging as a continuous phenomena of neuronal activity. Also the talk progressed to thephenomena how exercise, reduced intake of foods and rich living environment could
contribute to enhance neurogenesis and synaptic plasticity.
On the second day the talk started with the story about the cell death, then to plasticity ofneurons, with particular emphasis on BDNF as a central factor to control all the process ofneurogenesis, synaptic plasticity. Aging affects the BDNF production and reduces neuronal
synaptic plasticity. In contrast, exercise enhances BDNF production and can cope the aging
effects; a short time exercise of just 15 min three times a week could maintain theintelligence of senile persons. Having rich living environments is particularly important
after the age of retirement, such as to meet and talk with people, to read a book as for a
cognitive enrichment, to walk for exercising, but not to be alone all day long. The lecture iswell organized and integrated to the central story focusing on the cellular activity of rolesof calcium influx through NMDA receptors and roles of BDNF in development, synaptic
plasticity and aging. During the lecture, students asked Dr. Moody many questions on
various aspects of the lecture, and the classroom was active and was quite different fromthe usual lecture of generally quiet atmosphere.

Hearing: Physiology and aging
March 19, 2015
On the topics of hearing, 4 lectures were made in series. Dr. H Ohmori (Kyoto University)
first talked about cochlear mechanisms, and the pattern of afferent and efferent innervations.
His talk was the introduction for the audience on the physiology and aging of hearing, andexplained unique nomenclatures used in hearing physiology.

63Dr. N

Golding (Texas University, Austin, Texas, USA) talked on the central

mechanism of hearing focusing on the tonotopic organization, also talked about distinct
features of coding of sound temporal information and coding of sound intensity information.
The talk extended how the central auditory system extracts information about soundlocation; a spectral distortions by the outer ear as cues for sound source elevation, interauraltime differences (ITDs) as cues for horizontal sound source localization, and interaurallevel differences (ILDs), created by head shadowing of high frequency (> 2 kHz) sounds,
were also discussed as a cue for horizontal sound localization.
Dr. M Myoga (Max-Planck Institute, Munich, Germany) talked about encoding theauditory space, starting by a message that the representation of auditory space in the brain
is unique compared to other senses such as visual or somatosensory systems where space ismapped directly onto the sensory epithelia. Only frequency is mapped onto the cochlea,
thus spatial auditory information must be extracted entirely in the brain.
Dr. M

Burger (Lehigh University, Pennsylvania, USA) talked mainly about thetherapy for hearing loss, specifically in relation to cochlear implants. He talked that thesuccess of cochlear implants for restoring hearing function, and subsequently, the language
ability is highly dependent on 1) the age at which deafness occurs 2) the age at which
implantation is achieved. He also discussed some basic findings in humans regarding thecritical developmental period for language acquisition. Finally, he discussed a possibility ofcentral auditory implants and the potential for stem cell remedies for hearing loss.
All the lectures were well organized.

64ᖹᡂ䠎䠒ᖺᗘ ᾏእΏ⯟୍ぴ
ฟⓎ᪥

᪥ᩘ

┠ⓗᆅ

Ặ䚷䚷䚷ྡ

ᡤᒓ

⫋ྡ

Ώ⯟┠ⓗ

1

2014/4/27 7䜲䞁䝗䝛䝅䜰䞉
䝆䝵䜾䝆䝱䜹䝹䝍䚸▼஭䚷ຍ௦Ꮚ䝞䞁䝗䞁䚸䝆䝱䜹䝹䝍೺ᗣ㛗ᑑ♫఍䛾䜺䝆䝱䞉䝬䝎኱Ꮫ䚸䝞䞁䝗䞁ᕤ⛉኱Ꮫ䚸䜲䞁䝗䝛䝅䜰኱Ꮫ䜢ゼ⥲ྜ་⒪㛤Ⓨ䝴≉ᐃᩍᤵ ၥ䛧䚸䝥䝻䜾䝷䝮䛾ᗈሗάື䞉Ꮫ⏕່ㄏάື䠄Ꮫ⏕ᑐ㇟䛾䝥䝙䝑䝖䝻䜾䝷䝮⤂௓䝉䝭䝘䞊䠅
䠄LIMS䠅

2䜲䞁䝗䝛䝅䜰䞉
Dinh Ha Duy
2014/4/27 6 䝆䝵䜾䝆䝱䜹䝹䝍䚸
Thuy
䝞䞁䝗䞁

೺ᗣ㛗ᑑ♫఍䛾䜺䝆䝱䞉䝬䝎኱Ꮫ䚸䝞䞁䝗䞁ᕤ⛉኱Ꮫ䜢ゼၥ䛧䚸䝥䝻䜾䝷䝮䛾⥲ྜ་⒪㛤Ⓨ䝴≉ᐃຓᩍ ᗈሗάື䞉Ꮫ⏕່ㄏάື䠄Ꮫ⏕ᑐ㇟䛾䝥䝻䜾䝷䝮⤂௓䝉䝭䝙䝑䝖䝘䞊䠅
䠄LIMS䠅

䜲䜼䝸䝇䞉䝻䞁䝗䞁䚸䜿䞁䝤
2014/5/14 12 䝸䝑䝆

Ṋ⏣䚷ಇ୍

་Ꮫ◊✲⛉
ᨺᑕ⥺㑇ఏᏛ

ᩍᤵQueen Mary University of London, King's College
London, MRC Laboratory of Molecular Biology, Erasmus
MC 䜢ゼၥ䛧䚸ᒚಟ⏕䛾䜲䞁䝍䞊䝅䝑䝥ඛ㛤ᣅ䛾䛯䜑䛾ᡴྜ
䛫

Ṋ⏣䚷ಇ୍

་Ꮫ◊✲⛉
ᨺᑕ⥺㑇ఏᏛ

ᩍᤵ

University of Sussex, Queen Mary University of London,
Institute of Human Genetics, Max Planck Institute forHeart and Lung Research 䜢ゼၥ䛧䚸ᒚಟ⏕䛾䜲䞁䝍䞊䞁䝅䝑䝥ඛ㛤ᣅ䛾䛯䜑䛾ᡴྜ䛫▼஭䚷ຍ௦Ꮚ

೺ᗣ㛗ᑑ♫఍䛾⥲ྜ་⒪㛤Ⓨ䝴
M8 Alliance World Health Summit 2014 䛻ཧຍ䛧䚸䝥䝻䜾≉ᐃᩍᤵ䝙䝑䝖䝷䝮䛾௻⏬㐠Ⴀ䛻ಀ䜛ᗈሗάືཬ䜃ᅜ㝿㐃ᦠ䛾㛤ᣅ䠄LIMS䠅

▼஭䚷ຍ௦Ꮚ

೺ᗣ㛗ᑑ♫఍䛾International Conference on Biomedical Engineering,⥲ྜ་⒪㛤Ⓨ䝴≉ᐃᩍᤵ Technology and Application 䛻䛶ㅮ₇䜢⾜䛔䚸ᅜ㝿㐃ᦠ᥎䝙䝑䝖㐍䝥䝻䜾䝷䝮䛾ᗈሗ䞉Ꮫ⏕່ㄏ䠄LIMS䠅

Ṋ⏣䚷ಇ୍

་Ꮫ◊✲⛉
ᨺᑕ⥺㑇ఏᏛ

3䜸䝷䞁䝎䞉䝻䝑䝔䝹䝎䝮

䜲䜼䝸䝇䞉䝤䝷䜲䝖䞁䚸䝻䞁䝗䞁
4

2014/8/28 9

䝣䝷䞁䝇䞉
䝰䞁䝨䝸䜶
䝗䜲䝒䞉
䝞䞊䝖㻌䝘䜴䝝䜲䝮

5 2014/10/18 7 䝗䜲䝒䞉
䝧䝹䝸䞁

6

7

2014/11/6 5 䜲䞁䝗䝛䝅䜰䞉䝆䝵䜾䝆䝱䜹䝹䝍

2015/2/26 15䜹䝘䝎䞉䝞䞁䜽䞊䝞䞊
䜰䝯䝸䜹䞉
䝧䝉䝇䝎

ᩍᤵ

University of British Columbia 䛚䜘䜃 National Institute of
Health (NIH) 䜢ゼၥ䛧䚸ᒚಟ⏕䛾䜲䞁䝍䞊䞁䝅䝑䝥ඛ㛤ᣅ䛾䛯䜑䛾ᡴྜ䛫

65

Activities in Foreign Countries (Academic Year 2014)
Date of Departure

Days

Destination

1

April 27, 2014

7

Jogjakarta,
Bandung,
Jakarta,Indonesia

2

April 27, 2014

6

Jogjakarta,
Bandung,Indonesia

3

May 14, 201412

London,Cambridge,
UK
Rotterdam,
Netherlands

Name

August 28, 2014

9

Montpellier,FranceObjective

Kayoko Ishii

Public relation activities for LIMS Programand introduction / presentation to students at
University of Gadjah Mada, Institut Teknologi
Bandung, and University of Indonesia

Dinh Ha Duy
Thuy

ProgramSpecific
LIMS
Assistant
Professor

Public relation activities for LIMS Programand introduction / presentation to students at
University of Gadjah Mada and Institut
Teknologi BandungShunichiTakedaRadiation
Genetics,
Professor Graduate
School ofMedicine

Meetings for LIMS Students Internship at
Queen Mary University of London, King's
College London, MRC Laboratory of
Molecular Biology, and Erasmus MC

ShunichiTakedaRadiation
Genetics,
Professor Graduate
School ofMedicine

Meetings for LIMS Students Internship at
University of Sussex, Queen Mary Universityof London, Institute of Human Genetics, and
Max Planck Institute for Heart and Lung
Research

Bad Nauheim,
Germany

5

October 18, 2014

7

Berlin,Germany

Kayoko Ishii

ProgramSpecific LIMS
Professor

Public relation and international cooperation
activities at M8 Alliance World HealthSummit 2014

6

November 6, 2014

5

Jogjakarta,
Indonesia

Kayoko Ishii

ProgramSpecific LIMS
Professor

Public relation activity for LIMS Program andintroduction / presentation to students at
International Conference on Biomedical
Engineering, Technology and Application

ShunichiTakedaRadiation
Genetics,
Professor Graduate
School ofMedicine

Meetings for LIMS Students Internship at
University of British Columbia and National
Institute of Health (NIH)

766

Affiliation

ProgramSpecific LIMS
Professor

Brighton,
London,UK
4

Position

February 26, 201515

Vancouver,
CanadaBethesda,
USA

4.
学生の活動
Student Activities受 賞ᒚಟ⏕ࡀᮍ᮶ࡢክ࢔࢖ࢹ࢔࣭ࢥࣥࢸࢫࢺ࡛᭱ඃ⚽㈹ࢆཷ㈹
 /,06 ᒚಟ⏕0㸯ࡢᯇᮏ᭸Ꮚ࣭㐲㔝ᏹᏘ࣭す㇂ᬸᙪࡢ୕Ặࡀ᪥ᮏ⤒῭᪂⪺♫୺ദ➨㸵ᅇࠕ௻ᴗ࡟◊✲㛤Ⓨࡋ࡚࡯ࡋ࠸ᮍ᮶ࡢክࠖ࢔࢖ࢹ࢔࣭ࢥࣥࢸࢫࢺ㸦ឡ⛠㸸ࢸࢡࣀࣝࢿࢧࣥࢫ࣭ࢪࣕࣃࣥ㸧⸨᳃ᕤᴗ㒊㛛࡟࡚᭱ඃ⚽㈹ࢆཷ㈹ࡋࡲࡋࡓࠋ
͆ㄢ㢟ࢸ࣮࣐㸸ᮍ᮶ࡢໟࡴ౯್࡜ࡣ㸽͇࡜࠸࠺ࢸ࣮࣐࡟ᑐࡋࠊᑓᨷศ㔝ࡢ␗࡞ࡿ /,06 ࡢ௰㛫ࡓࡕ㸦་Ꮫ࣭ᕤᏛ࣭⸆Ꮫ㸧࡜ᛌ㐺࡞඘ᐇ♫఍ࢆᐇ⌧ࡍࡿࡓࡵࡢ࢔࢖ࢹ࢔ࢆ
ࡪࡘࡅྜ࠸ࠊసရࢆసࡾୖࡆࡲࡋࡓࠋࡇࡢ㈗㔜࡞⤒㦂ࡢ୰࡛ࠊࡇࡢୖ࡞࠸㐩ᡂឤ࡜඘ᐇឤࢆⓙ࡛࿡ࢃ࠺ࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ
 ࢥࣥࢸࢫࢺ࡟ࡘ࠸࡚᪥ᮏ⤒῭᪂⪺♫୺ദ➨㸵ᅇࠕ௻ᴗ࡟◊✲㛤Ⓨࡋ࡚࡯ࡋ࠸ᮍ᮶ࡢክࠖ࢔࢖ࢹ࢔࣭ࢥࣥ
ࢸࢫࢺ㸦ឡ⛠㸸ࢸࢡࣀࣝࢿࢧࣥࢫ࣭ࢪࣕࣃࣥ㸧࡜ࡣࠊ⌮ᕤ⣔ᩍ⫱ᨭ᥼௻⏬࡜ࡋ࡚ࠊ኱Ꮫ⏕ࠊಟኈㄢ⛬࣭༤ኈㄢ⛬኱Ꮫ㝔⏕ࠊ㧗➼ᑓ㛛Ꮫᰯ⏕㸦 ᖺ⏕௨ୖ࠾ࡼࡧᑓᨷ⛉㸧ࡢಶேࡲࡓࡣࢳ࣮࣒㸦ࢳ࣮࣒ࡣ  ྡࡲ࡛㸧ࢆཧຍ㈨᱁࡜ࡋࠊཧຍ௻ᴗࡢເ㞟ࢸ࣮࣐࡜ᢏ⾡ࢆඖ࡟ࠊ
ࠕ௻ᴗ࡟◊✲㛤Ⓨࢆࡋ࡚ḧࡋ࠸ᮍ᮶ࡢክࠖࢆᥦ᱌ࡍࡿࢥࣥࢸࢫࢺࠋ
⌮ᕤ⣔Ꮫ⏕ࡀ᪥ࡈࢁࡢ◊✲ࡢ࡞࠿࡛ࠊ
ࠕ௻ᴗࡀᣢࡘ᭱ඛ➃ᢏ⾡ࡀ࠶ࢀࡤࡇࢇ࡞ࡇ࡜
ࡀ࡛ࡁࡿ࠿ࡶࠖࠕࡇࢇ࡞〇ရࡀ࠶ࢀࡤᮍ᮶ࡣࡍ࡚ࡁ࡟࡞ࡿࡣࡎࠖ࡜ᛮ࠸ᥥࡃ࢔࢖ࢹ
࢔࡜௻ᴗࡢᢏ⾡ࡸ஦ᴗࢆ⤌ࡳྜࢃࡏࡓࡽ࡝ࢇ࡞⏬ᮇⓗ࡞ࡇ࡜ࡀ࡛ࡁࡿ࠿ࢆ⪃࠼ࡿሙ࡛ࠊཧຍ௻ᴗࡀ♧ࡍྛ♫ࡢເ㞟ࢸ࣮࣐࡜ᢏ⾡᝟ሗࢆࡶ࡜࡟ࠊࠕ௻ᴗ࡟◊✲㛤Ⓨࡋ࡚࡯ࡋ࠸ᮍ᮶ࡢክࠖࡢᥦ᱌ࢆເ㞟ࠋཧຍ௻ᴗྛ♫ࡢᢏ⾡⪅࣭◊✲ဨࠊᙺဨࡀᏛ⏕ࡢᥦ᱌ࢆᑂᰝࡋࠊ୍ḟ᭩㢮ᑂᰝࡢᚋࠊ᭱⤊ᑂᰝ࡛ࡣࠊᏛ⏕࡟ࡼࡿࣉࣞࢮࣥࢸ࣮ࢩࣙࣥ
࡜㉁␲ᛂ⟅࡟ࡼࡾ➇࠸ྜ࠸ࡲࡋࡓࠋ
ཧ⪃ࢧ࢖ࢺ㸸KWWSQLNNHLWHFKQRMS

68

Award[Award]LIMS Students won the first prize
at Idea Competition of Nikkei Techno Renaissance Japan
Course-wide interdisciplinary group of LIMS MC2 students, Mr Nobuhiko Nishitani, Ms
Tomoko Matsumoto and Mr. Hiroki Enno, won the first prize of Fujimori Kogyo (Zacros)award at the Scientific Idea Competition organized by Nikkei Shinbun, one of the quality
newspapers in Japan. The theme of the competition for the Fujimori Kogyo (Zacros)award was “The value of Wrapping in the future?”. Through the process to develop theirwork and the achievement of the prize, the students experienced an excellent senseof fulfillment and achievement.
About the contest:
The competition was the 7th open idea competition for undergraduate and postgraduate
students studying Science and Technology regarding a “dream for future corporate
research & development”. Participating companies issued the themes and their originaltechnologies for the competition subscription. The groups of students chose the themeand submitted their presentation about the proposals how the technologies that thecompanies developed can be integrated with their novel ideas, and create innovative
productions. Technicians, researchers and executives of the companies judged the student
submissions through proposal materials, presentations and Q&A session.
site㸸http://nikkei-techno.jp/

69

受 賞

➨㸰ᅇ 62*2 Ꮫ⾡ጤဨ఍Ꮫ⏕ᠱ㈹ㄽᩥ ᭱ඃ⚽㈹ࢆཷ㈹ࡋ࡚
་Ꮫ◊✲⛉ ⏕యᵓ㐀་Ꮫㅮᗙ ᙧែᙧᡂᶵ⬟Ꮫబஂ㛫 ┿⣖⛅Ꮫᮇ࡟ LIMS ࡢ་⒪⤒῭Ꮫࡢᤵᴗࢆᒚಟࡋࡲࡋࡓࠋࡇࡕࡽ࡛ࠊ༢⣧࡟ᢏ⾡ⓗ࡟㧗ᗘ࡞་⒪ࡸࠊ᭱᪂ࡢ◊✲ᡂᯝࢆྲྀࡾධࢀࡓ་⒪࡟ࡼࡗ࡚ࠊ
ࠕ㐍Ṍࠖࡣࡋࡓ࡜ゝ࠼ࡿ࠿ࡶࡋࢀ࡞࠸ࡀࠊ་⒪ࡢ㐍Ṍࡣ⤒῭ⓗ࡞㈇ᢸࢆቑࡸࡍࡔࡅ࡛ᑡᏊ㧗㱋໬♫఍ࡀ┤㠃ࡍࡿᵝࠎ࡞ၥ㢟ࡣゎỴࡋ࡞࠸࡜࠸
࠺ࠊ࠶ࡲࡾ⪃࠼ࡓࡇ࡜ࡢ࡞࠿ࡗࡓ⪃࠼᪉࡟ฟ఍࠸ࡲࡋࡓࠋ☜࠿࡟◊✲ࢆ㐍ࡵࡿࡇ࡜࡛ࠊ௒ࡲ࡛
἞ࡽ࡞࠿ࡗࡓ⑓Ẽࡀ἞ࡿࡼ࠺࡟࡞ࡿࡇ࡜ࡣ⣲ᬕࡽࡋ࠸ᡂᯝ࡛ࡍࡀࠊᐇ㝿࡟ࡇࡢ἞⒪ἲࡢࢥࢫࢺ
࡟ࡼࡗ࡚ࡣࠊ
ࠕᢏ⾡ⓗ࡟ྍ⬟࡛࠶ࡿࠖࡇ࡜࡜ࠕ⌧ᐇⓗ࡛ࠖ࠶ࡿࡇ࡜ࡣู࡛࠶ࡿࡇ࡜ࡶ☜࠿࡛ࡍࠋ᪤࡟ཝࡋ࠸㈈ᨻ≧ἣࡢ࡞࠿࡛ࠊ㠉᪂ⓗ࡛㧗㢠࡞་⒪ࢆ⾜࠺ࡇ࡜࡛ࠊࡉࡽ࡞ࡿᑑ࿨ࡢᘏ㛗ࢆ㐩ᡂࡋࠊࡉࡽ࡟་⒪㈝ࢆ⭾ࡽࡲࡏࡿ࡜࠸࠺᪉ྥᛶࡣࠊ♫఍ⓗ࡞せㄳ࡟ᛂ࠼࡚࠸ࡿࡇ࡜࡟࡞ࡿࡢ࠿ࡣ
࡞࠿࡞࠿㞴ࡋ࠸࡜ࡇࢁࡔ࡜ᛮ࠸ࡲࡍࠋࡇࡢࡼ࠺࡟⪃࠼࡚࠸ࡿ࡜ࡁࠊࡓࡲࡓࡲᡤᒓࡍࡿ◊✲ᐊࡢᲷ࡟ᑡᏊ㧗㱋໬࡜་⒪ࢆࢸ࣮࣐࡟ࡋࡓᏛ⏕ᠱ㈹ㄽᩥࢆເ㞟ࡋ࡚࠸ࡿ࡜ࡢ኱ࡁ࡞࣏ࢫࢱ࣮ࢆぢࡘࡅࡓࡢ࡛ࠊLIMS ࡢ་⒪⤒῭Ꮫ࡛Ꮫࢇࡔࡇ࡜ࢆࡶ࡜࡟ࠊ⮬ศ࡛ᑡᏊ㧗㱋໬࡟࠾ࡅࡿ་⒪ࢆ⪃࠼࡚ࡳࡼ࠺࡜ᛮ࠸ࠊసᩥࡋࡲࡋࡓࠋ ෆᐜ࡜ࡋࡲࡋ࡚ࡣࠊࡲࡎᑡᏊ㧗㱋໬ࡢ་⒪࡜࠸ࡗࡓ࡜ࡁ࡟ࠊ་⒪㈈ᨻࡀ❧ࡕ࠸࠿࡞ࡃ࡞ࡿ༴
㝤ᛶࢆࡣࡽࢇࡔேཱྀᵓ㐀࡛࠶ࡿࡇ࡜ࡀၥ㢟࡛࠶ࡾࠊ⤒῭ຠ⋡ࢆ㔜どࡋࡓ་⒪ࡀᚲせ࡛࠶ࡿࡇ࡜
ࢆࡲࡎ㏙࡭ࠊ⤒῭ຠ⋡ࢆ㔜どࡋࡓ་⒪ࡀ࡝ࡢࡼ࠺࡞ࡶࡢ࠿࡟ࡘ࠸࡚㆟ㄽࡋࡲࡋࡓࠋ୍␒ࢥࢫࢺ
ࡀ࠿࠿ࡽ࡞࠸ࡢࡣ་⒪ࢆᥦ౪ࡋ࡞࠸ࡇ࡜࡛ࡍࡀࠊ⚾ࡓࡕࡀ┠ᣦࡋ࡚࠸ࡿࡢࡣ㝈ࡽࢀࡓ㈨※ࡢ୰࡛࡝ࡢࡼ࠺࡞་⒪ࢆᥦ౪ࡍࢀࡤࠊᑗ᮶ୡ௦࡟ࢃࡓࡗ࡚ࠊ᭱኱㝈ࡢᖾ⚟ࢆ࠺ࡳࡔࡍࡇ࡜ࡀ࡛ࡁࡿ
࠿࡛࠶ࡾࠊ⚾ࡓࡕࡀ୍␒࡟⪃࠼࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࡢࡀࠊఱࢆࡶࡗ࡚᭱኱㝈ࡢᖾ⚟࡜ࡍࡿ࠿࡛࠶
ࡾࡲࡍࠋࡔࢀࡶࡀ᭱㧗ࡢ་⒪ࢆᑾࡃࡋࡓࢧ࣮ࣅࢫࢆཷࡅࡽࢀࡿࡢࡀ⌮᝿࡛ࡍࡀࠊࡑ࠺࠸࠺ࢃࡅ
࡟ࡶ࠸࠿࡞ࡃ࡞ࡗ࡚࠸ࡿ♫఍࡛ࡣࠊ་⒪ᢏ⾡ࢆ㐺ษ࡟ホ౯ࡋࠊࢥࢫࢺ࡟ぢྜ࠺ຠ⏝ࡢᚓࡽࢀࡿ
་⒪ࢆ㑅ᢥࡋࠊᏳ౯࡛࡛ࡁࡿ⏕ά⩦័ࡢᨵࡵࢆ
ಁࡋண㜵ࢆ㐍ࡵࡿࠊ᭱⤊ⓗ࡟ࡣᘏ࿨➨୍ࡢ౯್ࢆ㌿᥮ࡋࠊ࡝ࡢࡼ࠺࡞⏕ࡁ᪉ࠊṚ࡟᪉ࡀᖾࡏ࡞
ࡢ࠿ࢆ⪃࠼┤ࡍᚲせࡀ࠶ࡿ࡜࠸ࡗࡓࡇ࡜ࢆࡲ
࡜ࡵࡲࡋࡓࠋ ௒ᅇࡢᠱ㈹ㄽᩥࢆ᭩࠸࡚ࡳ࡚ࠊ/,06 ࡛ࡣ་⒪⤒῭ࡢᤵᴗࡔࡅ࡛࡞ࡃࠊຍ㱋་Ꮫࡸᵝࠎ࡞බ㛤ㅮ⩏ࠊ௻ᴗㅮᖌࡢ࠾ヰ࡞࡝ࢆ㏻ࡋ࡚ࠊᵝࠎ࡞ゅᗘ࠿ࡽᑡᏊ㧗㱋໬ࡢၥ㢟࡟ᑐᛂࡍࡿࡓࡵࡢ
ヨࡳࢆᏛࡤࡏ࡚࠸ࡓࡔࡁࠊࡑࢀࡽࡀ་⒪ࢩࢫࢸ
࣒ࡢ࡞࠿ࡢ࡝ࡢࣃ࣮ࢶ࡞ࡢ࠿ࢆ⮬ศࡢ࡞࠿࡛
ᩚ⌮ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋࡇࡢ㐣⛬࡛ࠊ་⒪ࢩࢫࢸ࣒ࡢ඲యീࡶᑡࡋࡎࡘ࡛ࡶᢕᥱࡍࡿࡇ
࡜ࡀ࡛ࡁࠊࡑࡢ୰࡛⮬ศࡀ࡝࠺࠸࠺❧ࡕ఩⨨࡛㛵ࢃࡗ࡚࠸ࡁࡓ࠸ࡢ࠿ࠊ࠸ࡃ࡭ࡁ࠿࡞࡝⪃࠼ࡿࡁࡗ࠿ࡅ࡟࡞ࡾࡲࡋࡓࠋ

70ᖹᡂ䠎䠒ᖺᗘ ᒚಟ⏕䛾Ꮫእάື䚷䛆እᅜ䛇
ฟⓎ᪥

᪥ᩘ

┠ⓗᆅ

Ặ䚷䚷䚷ྡ

ᡤᒓ

Ꮫᖺ

Ώ⯟┠ⓗ

బஂ㛫䚷┿⣖

་Ꮫ◊✲⛉
་⛉Ꮫᑓᨷ

RNA club June 2014䜈ཧຍ䛧䚸LIMS䝯䜲䞁䝔䞊䝬䛂䛜䜣἞⒪ಟኈㄢ⛬䜈䛾ᛂ⏝䜢┠ᣦ䛧䛯䝖䝷䞁䝇䜽䝸䝥䝖䞊䝮ゎᯒ䛃䛻ಀ䜛ཱྀ㢌Ⓨ䠎ᖺ⾲䛚䜘䜃᝟ሗ཰㞟The American Society of Hematology 2014䜈ཧຍ䛧䚸LIMSಟኈㄢ⛬䝯䜲䞁䝔䞊䝬䛂ⓑ⾑⑓䛻䛚䛡䜛⌧ᅾ䛾἞⒪ἲ䛃䛻ಀ䜛᝟ሗ཰䠍ᖺ㞟

1

2014/6/25

8

䝣䝷䞁䝇䞉
䝪䝹䝗䞊

2

2014/12/5

6

䜰䝯䝸䜹䞉
ᯇཎ䚷ᘯᖾ
䝃䞁䝣䝷䞁䝅䝇䝁

་Ꮫ◊✲⛉
་⛉Ꮫᑓᨷ

3

2015/1/7

5

ྎ‴䞉ྎ໭

➨6ᅇ᪥ᮏ-ྎ‴䝘䝜䝯䝕䜱䝅䞁䝅䞁䝫䝆䜴䝮䛻ཧຍ䛧䚸LIMS
ᕤᏛ◊✲⛉
ಟኈㄢ⛬
◊✲ㄢ㢟䛂⣽⬊ቑṪᅉᏊ➼䛾ᚎᨺ䛻䜘䜚⓶ୗ䛻స〇䛧䛯ච㧗ศᏊ໬Ꮫᑓᨷ 䠎ᖺ␿≉඾㒊఩䜈䛾⮅ᓥ⛣᳜䛃䛻ಀ䜛䝫䝇䝍䞊Ⓨ⾲

4

2015/2/66䜰䝯䝸䜹䞉஬᫂䚷⨾㤶Ꮚ
䝃䞁䝣䝷䞁䝅䝇䝁

᱔ཎ䚷௧

SPIE. Photonics West 2015䛻ཧຍ䛧䚸LIMS䝯䜲䞁䝔䞊䝬䛂ග
་Ꮫ◊✲⛉
ಟኈㄢ⛬
ே㛫೺ᗣ⛉Ꮫ⣔㉸㡢Ἴ㢧ᚤ㙾䛻䜘䜛⤌⧊ග㉸㡢Ἴ≀ᛶ䛾ᐃ㔞ⓗホ౯䛻㛵䛩䠎ᖺᑓᨷ䜛◊✲䛃䛻ಀ䜛᝟ሗ཰㞟Student Activities in Foreign Countries (Academic Year 2014)
Name

Grade, Affiliation

8

Bordeaux,
FranceMaki
SakumaM2,
Medical Science,
Graduate School of
Medicine

Oral presentation and information collection for
LIMS Research Issue: "Transcriptome analysis
with application in cancer treatment" at The RNA
Club June 2014

6

San
Francisco,
USA

HiroyukiMatsubara

M1,
Medical Science,
Graduate School of
Medicine

Information collection for LIMS Research Issue:"The treatment of leukemia" at The American
Society of Hematology 2014

Rei
Kuwabara

M2,
Polymer Chemistry,
Graduate School ofEngineering

Poster presentation for LIMS Research Project:"Transplantation of islets into immune privilegedsite prepared by sustained release of growth
factor under the skin" at The 6th Japan-Taiwan
Symposium on Nanomedicine

MikakoGomyo

M2,
Human Health
Sciences,
Graduate School of
Medicine

Information collection for LIMS Research Issue:"Quantitative assessment of photoacoustic
properties of biological tissues by photoacoustic
microscopy" at The SPIE. Photonics West 2015

Date of Departure Days Destination

1

June 25, 2014

2 December 5, 2014

3

January 7, 2015

4 February 6, 2015

5

Taipei,Taiwan6

SanFrancisco,
USA

Objective71ᖹᡂ䠎䠒ᖺᗘ㻌ᒚಟ⏕䛾Ꮫእάື䚷䛆ᅜෆ䛇
ฟⓎ᪥

᪥ᩘ

┠ⓗᆅ

Ặ䚷䚷䚷ྡ
ᡤ㻌㻌㻌㻌㻌㻌㻌ᒓ㻿㻭㻴㻭㻌㻸㼕㼠㼛㼚㻌㻷㼡㼙㼍㼞䚸㻭㼕㼘㼍㻌㻶㼛㼔㼍㼚㼚㼍䚸㻹㻮㻱㻺㼆㻭㻌㻹㻮㻭㻹㻮㻵㻌㻺㻭㻭㻿㻿㻻㻺䚸ᯇᮏ᭸Ꮚ䚸་Ꮫ◊✲⛉䚸⸆Ꮫ◊✲⠛⏣᪸ᶞ䚸Ᏹ㔝㞞ಇ䚸➉ୗ⮳䚸ᮎỌ࿴┿䚸⛉䚸ᕤᏛ◊✲⛉
㐲㔝ᏹᏘ䚸す㇂ᬸᙪ䚸஬᫂⨾㤶Ꮚ䠄㻹㻞䠅

Ꮫᖺ䠋⫋ྡ
ಟኈㄢ⛬
䠍ᖺ

䠄௨ୖ㻝㻝ྡ䠅
㻝

㻞

㻟

㻠

72

㻞㻜㻝㻠㻛㻠㻛㻞㻞㻞㻜㻝㻠㻛㻡㻛㻞

㻞㻜㻝㻠㻛㻢㻛㻝㻣㻞㻜㻝㻠㻛㻢㻛㻞㻣

㻝

㻝

㻡

㻝

ி㒔ᕷ

ዉⰋᕷ

ᶓ὾ᕷ

᳝ྡ䚷Ẏ䚷䠄ᘬ⋡䠅་Ꮫ◊✲⛉ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ䞉་⒪᝟ሗ䝅䝇 ᩍᤵ䝔䝮Ꮫ㏆⸨䚷೺ᝅ䚷䠄ᘬ⋡䠅೺ᗣ㛗ᑑ♫఍䛾⥲ྜ་⒪㛤Ⓨ䝴䝙䝑䝖䠄㻸㻵㻹㻿䠅≉ᐃຓᩍᯇཎᘯᖾ䚸㻿㻭㻴㻭㻌㻸㼕㼠㼛㼚㻌㻷㼡㼙㼍㼞䚸㻭㼕㼘㼍㻶㼛㼔㼍㼚㼚㼍䚸㻹㻮㻱㻺㼆㻭㻌㻹㻮㻭㻹㻮㻵㻌㻺㻭㻭㻿㻿㻻㻺䚸་Ꮫ◊✲⛉䚸⸆Ꮫ◊✲ᯇᮏ᭸Ꮚ䚸⠛⏣᪸ᶞ䚸ᇽୖஂ⨾Ꮚ䚸Ᏹ㔝㞞⛉䚸ᕤᏛ◊✲⛉
ಇ䚸➉ୗ⮳䚸ᮎỌ࿴┿䚸す㇂ᬸᙪ䚸஬᫂⨾㤶Ꮚ䠄㻹㻞䠅䚸᱔ཎ௧䠄㻹㻞䠅䚷䚷䠄௨ୖ㻝㻟ྡ䠅

ಟኈㄢ⛬
䠍ᖺ

㫽஭䚷⨾Ụ䚷䠄ᘬ⋡䠅೺ᗣ㛗ᑑ♫఍䛾⥲ྜ་⒪㛤Ⓨ䝴䝙䝑䝖䠄㻸㻵㻹㻿䠅

≉ᐃຓᩍ

▼⏣䚷ᩔᏊ

་Ꮫ◊✲⛉䞉
ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷಟኈㄢ⛬䠎ᖺ㻔㻝㻕ᯇᮏ᭸Ꮚ䚸㻔㻞㻕⠛⏣᪸ᶞ䚸㻔㻟㻕㐲㔝ᏹᏘ㻔㻝㻕་Ꮫ◊✲⛉䞉ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ䚸㻔㻞㻕⸆Ꮫ◊✲ಟኈㄢ⛬⛉䞉⸆⛉Ꮫᑓᨷ䚸㻔㻟㻕ᕤᏛ䠍ᖺ◊✲⛉䞉ྜᡂ䞉⏕≀໬Ꮫ
ᑓᨷ

ᒣཱྀ䚷୍┿

ᕤᏛ◊✲⛉䞉ྜᡂ䞉⏕≀
໬Ꮫᑓᨷ

ಟኈㄢ⛬
䠎ᖺ

▼஭䚷ຍ௦Ꮚ

೺ᗣ㛗ᑑ♫఍䛾⥲ྜ་⒪㛤Ⓨ䝴䝙䝑䝖䠄㻸㻵㻹㻿䠅

≉ᐃᩍᤵ

ᮾி㒔

┠㻌㻌㻌㻌㻌㻌㻌㻌ⓗᓥὠ〇సᡤ䠄ᮏ♫䞉୕᮲ᕤሙ䠅䛻䛶䚸Ꮫ㝿ᛂ⏝⛉┠䛂་⒪䞉⏕άᨭ᥼䝅䝇䝔䝮Ꮫ䛃䛻䛚䛡䜛་⏝⏬ീᶵჾ㛤Ⓨ⌧ሙ䛾ぢᏛᐇ⩦㧗䛾ཎ䝫䝅䝤䝹䝕䜲䜿䜰䝉䞁䝍䞊䛻䛶䚸Ꮫ㝿ᛂ⏝⛉┠䛂་⒪䞉⏕άᨭ᥼䝅䝇䝔䝮Ꮫ䛃䛻䛚䛡䜛㐠ື≉໬ᆺ䝕䜲䜿䜰䛾ぢᏛᐇ⩦➨㻝㻢ᅇୡ⏺సᴗ⒪ἲኈ㐃┕኱఍䞉➨㻠㻤ᅇ᪥ᮏసᴗ⒪ἲᏛ఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂⊂ᒃ㧗㱋⪅䛾ᅾᏯ⏕άᏳ඲ᛶ䛾䝸䝇䜽ホ౯䝒䞊䝹䛸䛧䛶䛾㻷㼕㼚㼑㼏㼠䛾ಙ㢗ᛶ䜔ጇᙜᛶ䛾᳨ウ䛃䛻㛵䛩䜛䝫䝇䝍䞊Ⓨ⾲䛚䜘䜃᝟ሗ཰㞟

䛂୰㛗ᮇ◊✲䜲䞁䝍䞊䞁䝅䝑䝥ᐇ᪋䛻ྥ䛡䛯Ꮫ⏕䞉ᩍ⫋ဨ䞉௻ᴗᢸᙜ⪅䛾㞟䛔䛃䛻ฟᖍ䛧䚸䜲䞁䝍䞊䞁䝅䝑䝥䛻ಀ䜛ពぢ஺᥮䞉᝟ሗ཰㞟㻡㻞㻜㻝㻠㻛㻝㻝㻛㻣

㻞

༓ⴥᕷ

ᐑஅཎ䚷㑂

⸆Ꮫ◊✲⛉䞉
⸆⛉Ꮫᑓᨷ

ಟኈㄢ⛬
䠎ᖺ

➨㻟㻠ᅇ་⒪᝟ሗᏛ㐃ྜ኱఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂㟁Ꮚ䜹䝹䝔䜢⏝䛔䛯䝔䜻䝇䝖䝕䞊䝍䝬䜲䝙䞁䜾䛃䛻ಀ䜛᝟ሗ཰㞟

㻢㻞㻜㻝㻠㻛㻝㻝㻛㻝㻞

㻞

ᮾி㒔

⠛⏣䚷᪸ᶞ

⸆Ꮫ◊✲⛉䞉
⸆⛉Ꮫᑓᨷ

ಟኈㄢ⛬
䠍ᖺ

䛂⣽⬊䜢๰䜛䛃◊✲఍㻣㻚㻜䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂⮫ᗋ䛸ศᏊ⏕≀Ꮫ䛛䜙䜏䛯ຍ㱋䛻䜘䜛䝞䜲䜸䝸䝈䝮䛾ኚ໬䛸⑌ᝈ䛾㛵㐃ᛶ䛾▱ぢ䛃䛻ಀ䜛᝟ሗ཰㞟㻣㻞㻜㻝㻠㻛㻝㻝㻛㻝㻡

㻞

㮵ඣᓥᕷ

ᐑஅཎ䚷㑂

⸆Ꮫ◊✲⛉䞉
⸆⛉Ꮫᑓᨷ

ಟኈㄢ⛬
䠎ᖺ

➨㻥ᅇ᪥ᮏ䝸䝝䝡䝸䝔䞊䝅䝵䞁་Ꮫ఍ᑓ㛛་఍Ꮫ⾡㞟఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂㟁Ꮚ䜹䝹䝔䜢⏝䛔䛯䝔䜻䝇䝖䝕䞊䝍䝬䜲䝙䞁䜾䛃䛻ಀ䜛᝟ሗ཰㞟㻤㻞㻜㻝㻠㻛㻝㻝㻛㻝㻢

㻟

ᮾி㒔

㐲㔝䚷ᏹᏘ

ᕤᏛ◊✲⛉䞉
ྜᡂ䞉⏕≀໬Ꮫᑓᨷ

ಟኈㄢ⛬䠍ᖺ➨㻟㻢ᅇ᪥ᮏ䝞䜲䜸䝬䝔䝸䜰䝹Ꮫ఍኱఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂㧗㱋໬䛻క䛳䛶Ⓨ⑕䛩䜛⑌ᝈ䛾ᘬ䛝㔠䛸䚸䛭䜜䜢ᢚไ䛩䜛໬Ꮫ≀㉁䛻㛵䛩䜛ᩥ⊩ㄪᰝ䛃䛻ಀ䜛᝟ሗ཰㞟㻥㻞㻜㻝㻠㻛㻝㻝㻛㻝㻢

㻟

ᮾி㒔

᱔ཎ䚷௧

ᕤᏛ◊✲⛉䞉
㧗ศᏊ໬Ꮫᑓᨷ

ಟኈㄢ⛬䠎ᖺ➨㻟㻢ᅇ᪥ᮏ䝞䜲䜸䝬䝔䝸䜰䝹Ꮫ఍኱఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂⣽⬊ቑṪᅉᏊ➼䛾ᚎᨺ䛻䜘䜚⓶ୗ䛻స〇䛧䛯ච␿≉඾㒊఩䜈䛾⮅ᓥ⛣᳜䛃䛻ಀ䜛ཱྀ㢌Ⓨ⾲䛚䜘䜃᝟ሗ཰㞟㻝㻜㻞㻜㻝㻠㻛㻝㻝㻛㻞㻜

㻟

௝ྎᕷ

ᮧᑿ䚷㈼

ᕤᏛ◊✲⛉䞉
㧗ศᏊ໬Ꮫᑓᨷಟኈㄢ⛬䠎ᖺ㟁Ꮚ᝟ሗ㏻ಙᏛ఍◊✲఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂⤫ྜኻㄪ⑕䛾䝞䜲䜸䝬䞊䜹䞊䛾᥈⣴䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻝㻞㻜㻝㻠㻛㻝㻝㻛㻞㻡

㻟

ᶓ὾ᕷ

➉ୗ䚷⮳

ᕤᏛ◊✲⛉䞉
ศᏊᕤᏛᑓᨷ

ಟኈㄢ⛬䠍ᖺ➨㻟㻣ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂㻰㻺㻭䝯䝏䝹໬␗ᖖゎᯒ䛻䜘䜛Ⓨ䛜䜣䝸䝇䜽ホ౯䛸⏕ά⩦័䛸䛾┦㛵䛻㛵䛩䜛◊✲䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻞㻞㻜㻝㻠㻛㻝㻝㻛㻞㻡

㻟

ᶓ὾ᕷ

Ᏹ㔝䚷㞞ಇ

ᕤᏛ◊✲⛉䞉
ศᏊᕤᏛᑓᨷ

ಟኈㄢ⛬䠍ᖺ➨㻟㻣ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂䝃䜲䝖䜹䜲䞁䝛䝑䝖䝽䞊䜽䛾␗ᖖ䛻ᇶ䛵䛟⮬ᕫච␿⑌ᝈ䛾Ⓨ⑕ᶵᵓ䛾ண ཬ䜃᳨ド䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻟㻞㻜㻝㻠㻛㻝㻝㻛㻞㻡㻟ᶓ὾ᕷᇽୖ䚷ஂ⨾Ꮚ

⸆Ꮫ◊✲⛉䞉
་⸆๰ᡂ᝟ሗ⛉Ꮫᑓᨷ

ಟኈㄢ⛬
䠍ᖺ

➨㻟㻣ᅇ᪥ᮏศᏊ⏕≀Ꮫ఍ᖺ఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂䝅䝣䝖䝽䞊䜹䞊䛜䛛䛛䜚䜔䛩䛔⑓Ẽ䛾◊✲䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻠㻞㻜㻝㻠㻛㻝㻝㻛㻞㻣㻝ᶓ὾ᕷ㻔㻝㻕ᯇᮏ᭸Ꮚ䚸㻔㻞㻕㐲㔝ᏹᏘ䚸㻔㻟㻕す㇂ᬸᙪ㻔㻝㻕་Ꮫ◊✲⛉䞉ே㛫೺ᗣ⛉Ꮫ⣔ᑓᨷ䚸㻔㻞㻘㻟㻕ᕤᏛ◊ ಟኈㄢ⛬✲⛉䞉ྜᡂ䞉⏕≀໬Ꮫᑓ 䠍ᖺᨷ᪥ᮏ⤒῭᪂⪺♫୺ദ➨㻣ᅇ䛂௻ᴗ䛻◊✲㛤Ⓨ䛧䛶䜋䛧䛔ᮍ᮶䛾ክ䛃䜰䜲䝕䜰䞉䝁䞁䝔䝇䝖䠄䝔䜽䝜䝹䝛䝃䞁䝇䞉䝆䝱䝟䞁䠅⸨᳃ᕤᴗ㈹䚷᭱⤊ᑂᰝ఍䛻䛶Ⓨ⾲㻝㻡㻞㻜㻝㻠㻛㻝㻝㻛㻞㻥

㻟

ᶓ὾ᕷ

ᐑஅཎ䚷㑂

⸆Ꮫ◊✲⛉䞉
⸆⛉Ꮫᑓᨷ

ಟኈㄢ⛬
䠎ᖺ

➨㻟㻟ᅇ᪥ᮏㄆ▱⑕Ꮫ఍Ꮫ⾡㞟఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂㟁Ꮚ䜹䝹䝔䜢⏝䛔䛯䝔䜻䝇䝖䝕䞊䝍䝬䜲䝙䞁䜾䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻢㻞㻜㻝㻠㻛㻝㻞㻛㻢

㻞

ᮾி㒔

ᮧᑿ䚷㈼

ᕤᏛ◊✲⛉䞉
㧗ศᏊ໬Ꮫᑓᨷಟኈㄢ⛬䠎ᖺ➨㻡ᅇ⬻⾲⌧ᆺ䛾ศᏊ䝯䜹䝙䝈䝮◊✲఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂⤫ྜኻㄪ⑕䛾䝞䜲䜸䝬䞊䜹䞊䛾᥈⣴䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻣㻞㻜㻝㻠㻛㻝㻞㻛㻝㻜

㻟

ி㒔ᕷ

Ᏹ㔝䚷㞞ಇ

ᕤᏛ◊✲⛉䞉
ศᏊᕤᏛᑓᨷ

ಟኈㄢ⛬䠍ᖺ➨㻠㻟ᅇ᪥ᮏච␿Ꮫ఍Ꮫ⾡㞟఍䛻ཧຍ䛧䚸㻸㻵㻹㻿䝯䜲䞁䝔䞊䝬䛂䝃䜲䝖䜹䜲䞁䝛䝑䝖䝽䞊䜽䛾␗ᖖ䛻ᇶ䛵䛟⮬ᕫච␿⑌ᝈ䛾Ⓨ⑕ᶵᵓ䛾ண ཬ䜃᳨ド䛃䛻ಀ䜛᝟ሗ཰㞟㻝㻤㻞㻜㻝㻡㻛㻟㻛㻝㻤

㻠

ᶓ὾ᕷ

᱔ཎ䚷௧

ᕤᏛ◊✲⛉䞉
㧗ศᏊ໬Ꮫᑓᨷ

ಟኈㄢ⛬䠎ᖺ➨㻝㻠ᅇ᪥ᮏ෌⏕་⒪Ꮫ఍⥲఍䛻ཧຍ䛧䚸㻸㻵㻹㻿◊✲ㄢ㢟䛂⣽⬊ቑṪᅉᏊ➼䛾ᚎᨺ䛻䜘䜚⓶ୗ䛻స〇䛧䛯ච␿≉඾㒊఩䜈䛾⮅ᓥ⛣᳜䛃䛻ಀ䜛ཱྀ㢌Ⓨ⾲䛚䜘䜃᝟ሗ཰㞟Student Activities in Japan (Academic Year 2014)
Date of Departure

Days

Name

Destination

Affiliation

SAHA Liton Kumar/ Aila Johanna/ MBENZAMBAMBI NAASSON/ Tomoko Matsumoto/
Graduate School of Medicine/
Kouki Shinoda/ Masatoshi Uno/ Itaru
Pharmaceutical Sciences/
Takeshita/ Kazumasa Suenaga/ Hiroki Enno/ Engineering
Nobuhiko Nishitani/ Mikako Gomyo(M2)123April 22, 2014

May 2, 2014

June 17, 2014

1

1

5

Kyoto

Nara

Medical Imaging System Sciences,
Human Health Sciences, Graduate Professor
School of Medicine

Kengo Kondo(Leader / Conductor)

LIMS

June 27, 2014

1

M1

Mie Torii(Leader / Conductor)

LIMS

ProgramSpecific
Assistant
Professor

Human Health Sciences,
Graduate School of Medicine

M2(1) Human Health Sciences,
Graduate School of Medicine(2) Pharmaceutical Sciences,
Graduate School of
Pharmaceutical Sciences(3) Synthetic Chemistry andBiological Chemistry, Graduate
School of Engineering

M1

Kazuma Yamaguchi

Synthetic Chemistry andBiological Chemistry, Graduate
School of Engineering

M2

Kayoko Ishii

LIMS

ProgramSpecificProfessor

Tokyo

Visiting Shimadzu Corporation (Head Office and Sanjo factory) and observing
development of medical image equipment for LIMS Medical and Life Support
Systems class.

ProgramSpecific
Assistant
Professor

Hiroyuki Matsubara/ SAHA Liton Kumar/ Aila
Johanna/ MBENZA MBAMBI NAASSON/
Graduate School of Medicine/
Tomoko Matsumoto/ Kouki Shinoda/ Kumiko
Pharmaceutical Sciences/
Dojo/ Masatoshi Uno/ Itaru Takeshita/Engineering
Kazumasa Suenaga/ Nobuhiko Nishitani/
Mikako Gomyo(M2)/ Rei Kuwabara(M2)

Yokohama Atsuko Ishida

Objective

M1

Tsuyoshi Shiina(Leader / Conductor)(1) Tomoko Matsumoto(2) Kouki Shinoda(3) Hiroki Enno
4

Grade/ Position

Visiting "Takanohara Possible Day Care Center" and observing day-care for LIMS
Medical and Life Support Systems class.

Poster presentation and information collection for LIMS Research Issue: "Aninvestigation of reliability and validity on Kinect as the tool of safety life for older
adults" at The 16th International Congress of the World Federation of Occupational
Therapists in collaboration with the 48th Japanese Occupational Therapy Congress
and Expo

Information collection and exchange of ideas for LIMS Internship Program at the joint
workshop: "Meeting of Students, Faculty Staff, and Companies for Medium- andLong-Term Research Internship Program"

5

November 7, 2014

2

Chiba

Jun Miyanohara

Pharmaceutical Sciences,
Graduate School of
Pharmaceutical Sciences

M2

Information collection for LIMS Research Project: "Text data mining using electronic
medical records" at the 34th Joint Conference on Medical Informatics

6

November 12, 2014

2

Tokyo

Kouki Shinoda

Pharmaceutical Sciences,
Graduate School of
Pharmaceutical Sciences

M1

Information collection for LIMS Research Issue: "Association between age-relatedchanges in biorhythm and disease onset; chronobiological study and its application toclinical treatment" at The Japanese Society for Cell Synthesis Research 7.0

7November 15, 2014

2

Kagoshim
Jun MiyanoharaaPharmaceutical Sciences,
Graduate School of
Pharmaceutical Sciences

M2

Information collection for LIMS Research Project: "Text data mining using electronic
medical records" at The 9th Scientific Meeting of the Japanese Board-certificatedPhysiatrist Association

8

November 16, 2014

3

Tokyo

Hiroki Enno

Synthetic Chemistry andBiological Chemistry, Graduate
School of Engineering

M1

Information collection for LIMS Research Issue: "Literature search on the relationshipbetween age-related diseases in the elderly and the chemical compounds that inducethem" at The 36th Japanese Society for Biomaterials

9

November 16, 2014

3

Tokyo

Rei Kuwabara

Polymer Chemistry, Graduate
School of Engineering

M2

Oral Presentation and information collection for LIMS Research Project:"Transplantation of islets into immune privileged site prepared by sustained releaseof growth factor under the skin" at The 36th Japanese Society for Biomaterials

10

November 20, 2014

3

SendaiKen Murao

Polymer Chemistry, Graduate
School of Engineering

M2

Information collection for LIMS Research Project: "Investigation of biomarker formental disorder" at The Institute of Electronics, Information and Communication
Engineers(IEICE)

11

November 25, 20143

Yokohama Itaru Takeshita

Molecular Engineering, Graduate
M1
School of Engineering

Information collection for LIMS Research Issue: "Research on the evaluation ofcarcinogenic risk using DNA methylation analysis and the relationship between the
carcinogenic risk and life style" at The 37th Annual Meeting of the Molecular Biology
Society of Japan

12

November 25, 20143

Yokohama Masatoshi Uno

Molecular Engineering, Graduate
M1
School of Engineering

Information collection for LIMS Research Issue: "Prediction and validation of theonset mechanism of autoimmune disease based on disorder in the cytokine network"at The 37th Annual Meeting of the Molecular Biology Society of Japan

13

November 25, 20143

Yokohama Kumiko Dojo

Bioinformatics and Chemical
Genomics, Graduate School of
Pharmaceutical Sciences

M1

Information collection for LIMS Research Issue: "The Health Risks of Shift Work" at
The 37th Annual Meeting of the Molecular Biology Society of Japan

14

November 27, 2014

1

(1) Tomoko Matsumoto
Yokohama (2) Hiroki Enno
(3) Nobuhiko Nishitani(1) Human Health Sciences,
Graduate School of Medicine(2,3) Synthetic Chemistry andBiological Chemistry, Graduate
School of Engineering

M1

Presentation at the final review of the Fujimori Kogyo (Zacros) award, Scientific Idea
Competition organized by Nikkei Shinbun: "The 7th Nikkei-Techno RenaissanceJapan"

15

November 29, 20143

Yokohama Jun Miyanohara

Pharmaceutical Sciences,
Graduate School of
Pharmaceutical Sciences

M2

Information collection for LIMS Research Project: "Text data mining using electronic
medical records" at The 33rd Annual Meeting of Japanese Society for Dementia
Research

16

December 6, 2014

2

Tokyo

Ken Murao

Polymer Chemistry, Graduate
School of Engineering

M2

Information collection for LIMS Research Project: "Investigation of biomarker formental disorder" at The 5th Comprehensive Brain Molecular Mechanism

17

December 10, 2014

3

Kyoto

Masatoshi Uno

Molecular Engineering, Graduate
M1
School of Engineering

Information collection for LIMS Research Issue: "Prediction and validation of theonset mechanism of autoimmune disease based on disorder in the cytokine network"at The 43rd Annual Meeting of the Japanese Society for Immunology

18

March 18, 2015

4

Polymer Chemistry, Graduate
School of Engineering

Oral Presentation and information collection for LIMS Research Project:"Transplantation of islets into immune privileged site prepared by sustained releaseof growth factor under the skin" at The 14th Congress of the Japanese Society for
Regenerative Medicine

Yokohama Rei Kuwabara

M2

73

Student Activity Report(M1 Students)
AnnualReport2014
LIMS
AnnualReport2014
Department of Medical Science
Department of Medical Science
Graduate School of Medicine
Graduate School of Medicine
Hiroyuki Matsubara
Hiroyuki Matsubara(1) Pre-research
Subject: NK cells derived from iPS cells for a clinical application
 The idea in the study
Immunological research has contributed to many discoveries in treatments for cancers.
Currently, the majority of cancer treatments depend on anticancer drugs which are liable
to be accompanied with many side effects by influencing normal cells. To cover thisproblem, we thought immunotherapy using the Natural Killer (NK) cells is useful,because they can attack cancer cells that have acquired mechanisms to escape from
immune cells.
 NK killer assay
In 2014, I tried to create the NK killer assay system using NK cells from PBMC
(Peripheral Blood Mononuclear Cell) (Fig. 1). K562, a leukemia cell-line, co-cultured
with NK cells for 2 hours at 37, and analyzed cytotoxicity of NK cells using FACS. As
shown in Fig. 1, K562 cells were labeled with PKH2 Green Fluorescent Cell Linker to
identify each cell. The cytotoxic activity of NK cells was confirmed by increased number
of DAPI+ cells in PKH-labeled K562 cells co-cultured with NK cells. (Fig. 2).
 Participation in academic meeting
I attended American society of hematology 2014 (2014.12.06-09).

          



74



Fig.1 NK killer assay
Fig.2 Killing potential of NK cells derived from PBMC


Lecture and Training
In 2014, I took classes of English Debate, Human Anatomy, and Physiology. It wasvery valuable experience by observing and understanding the structure of the human bodyby Human Anatomy class in particular. Through the lectures and seminars of Medical andlife support systems, I could learn a lot of things about medical front.



LIMS
AnnualReport2014
AnnualReport2014
Department of Radiation Genetics
Department of Medical Science
Graduate School of Medicine
Graduate School of Medicine
SAHA Liton Kumar
SAHA Liton Kumar(1) Academic
I have been introduced with basic knowledge in medical field by studying human anatomy
and physiology throughout this year. I participated the theory and practice classes of medical
and life support systems which gave me an idea about the current health care system andexisting problems in health care system in Japan. I got a provoking idea about the Japanesemodel to improve public health care all over the world. I attended some classes of medical
engineering for society I course and it seems quite interesting to me. By participating debateclass my communication and presentation skill has been improved.

(2) Research
Topic: Establishment of in vitro micronucleus assay using DNA repair deficient human
lymphoblastoid TK6 cell line to detect genotoxic chemicals
Here is the objective, summary and progress so far of my research under LIMS program:
Today, U.S. and EU chemical manufacturers comply with a massive amount of data75

(2) Research
Topic: Establishment of in vitro micronucleus assay using DNA repair deficient human
lymphoblastoid TK6 cell line to detect genotoxic chemicals
Here is the objective, summary and progress so far of my research under LIMS program:
Today, U.S. and EU chemical manufacturers comply with a massive amount of datacollection, reporting and other regulatory requirements, many of which are vital to ensuring
the health and safety of chemicals. In the chemical sector, innovation and chemistry are
inextricably linked. From applied technology in medical devices, aerospace, energy
efficiency, computing, cars, fuels and more, chemistry enables technological advancementsthat drive further innovation, create jobs and enhance safety in our everyday lives. The
REACH Regulation represents a major piece of chemical legislation in the EU and requires
manufacturers and importers of chemicals to assess the safety of their substances.
Epidemiology suggests that most cancers are induced by environmental factors. The use of
screening tests which are dependent upon chemical interaction with DNA has greatly
facilitated the identification of probable chemical carcinogens. Interpretation of the test
results is never easy, in terms of human risk assessment, and is further complicated by thepresence of other chemicals in an environmental context. The issue of risk assessment ofgenotoxic and carcinogenic substances is relevant for chemicals used or present in foods,
nonfoods, industrial applications, and is one that poses significant challenges to the risk
managers. Biomarkers of genotoxic effects include: DNA-adducts including oxidative
damage to the DNA, which may be detected by the comet assay, chromosomal aberrations,sister chromatid exchanges, increased frequency of micronuclei. A number of short-term
genotoxicity tests that differ in biological system (prokaryotic, eukaryotic, in vitro, or invivo) and endpoint (gene mutation, chromosome aberration, DNA damage, etc.) have beendeveloped and optimized over the years. Because no single test is capable of detecting all
genotoxic chemicals, a battery of tests covering different targets and endpoints and using
different systems is used for regulatory evaluations [ICH, 1995]. Due to the development ofhighly sensitive analytical techniques, the use of biomarkers becomes increasingly importantin exposure assessment since it provides more exact information on actual internal exposure(target dose) to an agent. (Angerer et al. 2007, Boogaard 2007, Calafat et al. 2006, Needham
et al. 2007, Pirkle et al. 2005, Yang et al. 2006b).Improving the quality of these assessments
will lead to significant benefits for everyone. It will help drive better public health decisions
based on accurate information and better use of public and private sector resources that canbe refocused on protecting the public and the environment and on promoting jobs andinnovation.
Most DNA repair-deficient mutants are hypersensitive to DNA damaging agents, which led
us to realize that these strains could be used as an assay system to identify putative
genotoxins with greater sensitivity than existing assays. We propose the development of new76

methodologies to perform IVMN (In vitro micronucleus) assay using DNA repair deficient
TK6 cell line. The issue of false-positive results in the standard in vitro genotoxicity assays
and challenges with follow-up testing are recognized as a critical issue in the global genetic
toxicology community. One approach to address this issue is to develop improved in vitroMost DNA repair-deficient mutants are hypersensitive to DNA damaging agents, which led
us to realize that these strains could be used as an assay system to identify putative
genotoxins with greater sensitivity than existing assays. We propose the development of new
methodologies to perform IVMN (In vitro micronucleus) assay using DNA repair deficient
TK6 cell line. The issue of false-positive results in the standard in vitro genotoxicity assays
and challenges with follow-up testing are recognized as a critical issue in the global genetic
toxicology community. One approach to address this issue is to develop improved in vitro
genotoxicity assays. Our focus has been on the use of DNA repair deficient TK6 models fordevelopment of a new more sensitive, physiologically relevant and in vitro MN assay withgreater specificity.
We are proposing the use of panel of DNA repair TK6 mutants in the following pathway:
Rad54 and Ligase4 (HR and NHEJ, respectively); Fancd2 (Inter-strand closslink repair);
Rev3, Rad18 (TLS) and XRCC1 (Base excision repair).We are planning to use human TK6cell line because this cell line has some greater advantages than other cell line in terms ofgenotoxicity test and the findings would be physiologically relevant to assessment of risk ofgenotoxin to human health.
In this year, I have learned how to make gene disrupted human cell using TALEN and
CRISPR/CAS9 technology. I have also learned several research technique of molecularbiology. The generation of XRCC1 deficient and FANCD2 deficient human TK6 B cell line
is under progress.
Generation of human FANCD2−/−TK6 B cells
To disrupt FANCD2, guide RNA targeting first codon using Zhang CRISPR tool
(F Ann Ran et al., 2013) and gene-targeting constructs were generated.The gene-targeting
constructs were generated from genomic DNA of TK6 cells by amplifying with the primers
for the 5′-arm and for the 3′-arm. Genomic PCR products were combined with neomycin
resistance (neoR) and puromycin resistance (puroR) marker genes. 6 μg of CRISPR and 2
μg each of gene-targeting vectors were transfected into 4×106 TK6 cells using Neontransfection system (Life Technologies, US). After electroporation, cells were released into
20 ml drug-free medium. 48 hours later, cells were seeded into 96-well plates for selection
with both neomycin and puromycin antibiotics for two weeks.
The FANCD2 gene deficient clones will be confirmed by western blot analysis.
Generation of human XRCC1−/− TK6 B cells
To disrupt XRCC1, TALEN expression plasmids and gene-targeting
constructs were generated. The gene-targeting constructs were generated from genomic
DNA of TK6 cells by amplifying with primers for the 5′-arm and for the 3′-arm. Genomic
PCR products were combined with histidinol D resistance (hisR) and blasticidin S resistance(bsrR) marker] genes. 6 μg each of TALEN expression plasmids and 2 μg each of genetargeting vectors were transfected into 4×106 TK6 cells using Neon transfection system(Life Technologies, US). After electroporation, cells were released into 20 ml drug-free
medium. 48 hours later, cells were seeded into 96-well plates for selection with both77

Generation of human XRCC1−/− TK6 B cells
To disrupt XRCC1, TALEN expression plasmids and gene-targeting
constructs were generated. The gene-targeting constructs were generated from genomic
DNA of TK6 cells by amplifying with primers for the 5′-arm and for the 3′-arm. Genomic
PCR products were combined with histidinol D resistance (hisR) and blasticidin S resistance(bsrR) marker] genes. 6 μg each of TALEN expression plasmids and 2 μg each of genetargeting vectors were transfected into 4×106 TK6 cells using Neon transfection system(Life Technologies, US). After electroporation, cells were released into 20 ml drug-free
medium. 48 hours later, cells were seeded into 96-well plates for selection with both
histidinol and blasticidin antibiotics for two weeks.
The XRCC1 gene deficient clones will be confirmed by western blot analysis.

Learning Acquisition
Acquisition ofof thethe Integrated
Integrated Medical
Medical System
SystemLearningof Morphological Brain Science
Department of Department
Medical Science
Graduate School of MedicineGraduate School of Medicine
Aila Johanna
Aila Johanna
To allow for better evaluation, the report is segmented based on the objectives of Training
Program of Leaders for Integrated Medical System.
(1) Society-directed medicine and healthcare system
Population aging is a demographic tendency that requires countries to restructure theirstrategies. Although this occurs worldwide, Japan has the most surprising growth rate of aging
population. Courses such as the Medical and Life Support System introduced the issues any
aging society faces, and how the national health system and social welfare organizations needto equip the elderly population to optimize their activities of daily living and minimize healthproblems. The field trips conducted gave students a chance to observe the operation of physicalrehabilitation and elderly care centers.
One important lesson is how to actually view the breach of the issue. The course taught uswhich data should be looked at to judge the demographic impact of an aging society. The
dependency ratio, for one, is used to measure the burden of dependents which has to besupported by the working population. Calculated as the ratio of the number of nonworking
population per 100 persons of working population, with the ‘working population’ be
generalized as people aged 15 to 64 years old. Another data is the potential support ratio, which
is defined as the working population divided by the number of persons aged 65 and above. Thisdata is used to predict the support base at hand. From this information, one could assess thedemographic impact of aging in other countries despite differences in economic or sociodemographic profiles. For example, the data for dependency ratio and potential support ratio in
Indonesia are presented in figure 1 and 2, respectively.
78

generalized as people aged 15 to 64 years old. Another data is the potential support ratio, which
is defined as the working population divided by the number of persons aged 65 and above. Thisdata is used to predict the support base at hand. From this information, one could assess thedemographic impact of aging in other countries despite differences in economic or sociodemographic profiles. For example, the data for dependency ratio and potential support ratio in
Indonesia are presented in figure 1 and 2, respectively.

Figure 1. Past and projected trends in Dependency Ratio in Indonesia
Source: Adioetomo SM, Mujahid G. Indonesia on the threshold of population ageing. UNFPA 2014.

Figure 2. Past and projected trends in Potential Support Ratio in Indonesia
Source: Adioetomo SM, Mujahid G. Indonesia on the threshold of population ageing. UNFPA 2014.

Specific health problems associated with aging were also learned throughout the program,from classes and seminars. Since aging is associated with the functional decline of many organsystems of the human body, health problems in geriatric population are usually multiple andtherefore hard to completely obliterate. This puts an emphasis on improving general quality oflife in geriatric science.
(2) Industrialization, innovation, and intellectual rights
Learning about innovation and industry development in the course Medical Engineering
for Society, a chance to try for its application came through the Nikkei Science Idea Contest.
The contest is held annually through industry cooperation, in which each technology-based
company gives its own topic. Participation was taken for the one brought by Zacros (Fujimori
Kogyo Co., Ltd) on the topic of proposing new function of wrapping for a comfortable life in
future prosperous society. Along with four other students of LIMS training program, ideas forsuch innovation were subsequently discussed. Following the result of the competition,
discussion for patent proposals were also carried out.
(3) Health economics and policy
Health insurance system was learned through a course where students discuss thecomparison between the insurance systems of several countries. Some health policies related tothe burden of an aging nation was also delivered through the course in first semester.
English Debate course provided us the opportunity to practice structuring a policy proposal.
This allowed for the understanding of what aspects one should compare and contrast between

79

such innovation were subsequently discussed. Following the result of the competition,
discussion for patent proposals were also carried out.
(3) Health economics and policy
Health insurance system was learned through a course where students discuss thecomparison between the insurance systems of several countries. Some health policies related tothe burden of an aging nation was also delivered through the course in first semester.
English Debate course provided us the opportunity to practice structuring a policy proposal.
This allowed for the understanding of what aspects one should compare and contrast between
the countries / areas encompassed within the pilot study, and the country / area intended as thetarget for the policy.
(4) Collaborations for healthcare systems
An upcoming activity is to take participation in the World Health Summit Regional
Meeting 2015 in Kyoto, Japan. The conference shall discuss the current measures in geriatriccare and the reshaping of healthcare that would be better suited to a rapidly aging society.
Another agenda to be assessed is the physical and mental health issues related to disasters andenvironmental hazards, which shall broaden my scope of health-related concerns of the society
today.

ANNUAL REPORT
Department of Medical Science
Graduate School of Medicine
MBENZA MBAMBI NAASSON(1) Introduction
As a first year Master student (M1) of LIMS program, I learned and acquired knowledge
and skills regarding different courses that I selected.
Especially, human Anatomy course, which helped everybody work on dead bodies. And also
physiology for mastering the body’s function through different organs and system.
Kinesiology course for muscles, bones and joints functioning.
Medical life support for which we visited rehabilitation day care center, Welfare
Institution and Community General Support Center and Consultation Center providing
advice to elderly patients. From these visits I learned how to help elderly people recover
their ability lost.
English debate course, which helped boost my communication skills. Biopharmaceutics,
which helped me refresh and learned the leading edge improvements in DDS (drug delivery
system) by focusing on Targeting through pharmacokinetic processes ADME (Absorption,
Distribution, Metabolism and Excretion).

80

(2) Research ProgressFirst, I wanted to work on tuberculosis in DRCongo and I was advised by my supervisorsand mentors to work on project that does not involve a lot of laboratory experiments anddoes not require me to go to DRCongo for collecting samples since I am already involved ina laboratory based research project. Then I decided to work on learning from Japanese healthcare insurance system for improving DRCongo health insurance system.
Because Japan’s health care system is characterized by universal coverage, free choice of
health care providers by patients, a multi-payer, employment based system of financing, anda predominant role for private hospitals and fee-for-service practice.
Virtually all residents of Japan are covered without regard to any medical problems(so-called predisposing conditions) or actuarial risk of succumbing to illness. Thus making
it a good health care insurance system to learn from.

LIMS
activitybroadened mymy horizons
horizons remarkably
LIMS
activityhashasbroadened
remarkably
Department
Department of Human Health
Sciencesof Human Health Sciences
Graduate School of Medicine Graduate School of Medicine
MATSUMOTO Tomoko
Tomoko Matsumoto(1) Participating in “the Meeting on Carrying out the Internship System for Students,
Faculty, an Staffs of both university and company” sponsored by the Ministry of
Economy, Trade and Industry.㸦2014.June㸧
In this meeting we had a workshop to discuss on several problems involved the long andmiddle term
systemof LIMS
This workshop
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terminternshipinternshipsystem.
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andandgovernment,
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problems andonsolutionsof andthe longand middle
be deepened
fromseveralfrom several
distinct views.
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Mygroupgroupin inwhich
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most among
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discussion
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difficultyopinions
of exchanging
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I felt by
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exchanging
amongopinions who
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who situations
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an weexperiencethat wecanpossibility
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variousexchangewith
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Moreoverthis meeting
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universities.

81

opinions among persons who have different situations and viewpoints. But on the other hand,I think the possibility to find the new solution through such an experience that we canexchange various opinions with the diversity. Moreover this meeting was a precious andwonderful opportunity for me because of an interchange with other faculty, staffs, andstudents of the Leading Graduate Program of other universities.

(2) Participating in “Science Idea Contest named ࢸࢡࣀࣝࢿࢧࣥࢫ” sponsored by The
NIKKEI and Winning a First Prize
In this summer, I gathered several LIMS members and discussed the subject, “what is thevalue of wrapping for future?” And then we built up the idea and applied for Science Idea
Contest hosted by The Nikkei. In result we could win the first prize. By this experience I felt
the importance of intellect concentration in various field. Moreover we want to produce thisnovelty item on commercial basis, and then make innovations in the society for the future.

(3) Participating in a lot of LIMS lectures
Generally speaking, students of the graduate school have a tendency to get theirhorizons and knowledge narrow, specialized their study field. However in this LIMS program
there are many lectures in various fields such as Engineering, Medical Science, Pharmacology
and so on. Therefore we can learn various fields of study. I have also taken lots of lectures in
LIMS and experienced various practical studies. For example, I participated in Medical
Engineering for Society, Minimally invasive therapeutics, Special class lectured by professorof other Universities, Physiology, Basic Materials Chemistry and so on. Now I haveappreciated for LIMS program to get me widen my horizon thanks to LIMS program And I
could also experience more special studies.
I talk about most valuable experience in LIMS lectures,
82

Minimally Invasive Therapeutics. In this class, I could
experience in the real medical treatment site and then learned
what it is performed there and how doctors is doing inEngineering for Society, Minimally invasive therapeutics, Special class lectured by professorof other Universities, Physiology, Basic Materials Chemistry and so on. Now I haveappreciated for LIMS program to get me widen my horizon thanks to LIMS program And I
could also experience more special studies.
I talk about most valuable experience in LIMS lectures,
Minimally Invasive Therapeutics. In this class, I could
experience in the real medical treatment site and then learned
what it is performed there and how doctors is doing insurgical treatments. For example I knew the differences
between “endoscope and laparoscopic surgical operation
system” and “Surgery support system and surgical robot Figure㸸Surgical robot systemsystem”. These two systems have a same point to use theendoscope in surgical treatment. On the other hand they are very difficult of a viewing field
and the way of surgical treatment. I surprised these differences and felt there were muchpoints to be improved. I realized the importance of “Seeing is believing” strongly.
Therefore I want to make full use of my knowledge and experience which I learned in
the LIMS program.

LIMS
AnnualReportAnnualReportDivisionof Pharmaceutical Sciences
Department of Pharmaceutical
Sciences
SchoolSciencesof Pharmaceutical Sciences
Graduate School of Graduate
Pharmaceutical
Kouki Shinoda
Kouki Shinoda(1) Pre-research
Theme: ‘Association between age-related changes in biorhythm and disease onset;
chronobiological study and its application to clinical treatment’
It is well known that biorhythm can change during aging. Recently, it has been reported that
this change is related to various diseases. As the research of LIMS program, I am trying toclarify the correlation between age-related changes in biorhythm and disease onset from aviewpoint of chronobiology and molecular biology. In the future, I hope to propose newdevices or way of better living for improving QOL of elderly people.
In this year, based on documents and articles, I investigated diseases related to biorhythm,
especially circadian rhythm, and found that it is suggested that diseases such as sleepdisorder, high blood pressure and bronchial asthma are related to biorhythm change.
Moreover, it was reported that a disorder of the circadian rhythm by working during nighttime had an influence on the melatonin secretion and it could become the onset factor ofbreast cancer and mental diseases. Some modifications of drug release and drug
administration systems to relieve disease symptoms varied with circadian rhythm were also
reported, such as a controlled release formulation of antiasthmatic drug ‘theophylline’ and‘chrono-pump’. It is thought that these reports are closely related with my research themein LIMS program.
To study the basic chronobiology, its history, and the latest experimental technologies, I83

disorder, high blood pressure and bronchial asthma are related to biorhythm change.
Moreover, it was reported that a disorder of the circadian rhythm by working during nighttime had an influence on the melatonin secretion and it could become the onset factor ofbreast cancer and mental diseases. Some modifications of drug release and drug
administration systems to relieve disease symptoms varied with circadian rhythm were also
reported, such as a controlled release formulation of antiasthmatic drug ‘theophylline’ and‘chrono-pump’. It is thought that these reports are closely related with my research themein LIMS program.
To study the basic chronobiology, its history, and the latest experimental technologies, I
took part in ‘CBS2014, Chronobiology Summer School in 2014 in Sapporo’ and ‘Sapporo
Symposium on Biological Rhythm’. I learned how the change of the light and dark
condition influenced circadian rhythm and why the suprachiasmatic nucleus were regarded
as the center of the circadian clock.
To expand my knowledge of molecular biology, I attended ‘the Seventh Annual Meeting of
the Japanese Society for Cell Synthesis Research’. It was thought that the approach tosynthesis or control cells was useful for controlling rhythmic changes in cellular level andapplying it to therapy. I was able to obtain important viewpoints for my research theme.
I am going to push forward documents investigation about the association of aging and thebiorhythm.
(2) Practices and Lectures
I was able to take classes in a wide range of fields such as medicine, engineering, debate inEnglish and the lecturers from the companies. I would never be able to study these,
belonging only to Faculty of Pharmaceutical Sciences. Especially, in human anatomy class,we were able to observe the corpse directly and learn the basic structures of human bodycomparing those listed in a textbook one by one. I realized preciousness of the life again. I
hope I could make use of this experience when I study on life science and engage myself ina medical industry in the future.
In Medical and life support systems, we visit hospitals, day-care center and several
companies. Through the field trips to the work sites of physical therapists and theoccupational therapists and to the daycare center, I learned the various needs in the medicalsites. In addition, I obtained information about the device development and the technical use
in the medical industry by visiting Shimadzu Corporation which develops and is selling CT
and MRI.
In Medical Engineering for Society I, I had opportunities to take lectures on various topics
directly connected with the business, such as standardization and intellectual property rights,
to development of medical equipment and the material. I was able to learn about the current
reality of medical and care fields and a way of thinking, about research and development as
a business, which would be hard to get in the laboratory.
Next year, I keep studying medicine and engineering, aiming to suggest a new businessmodel to meet the needs of longevity society and to connect them with my research themein LIMS program.

84

Pathological Treatment for Shift Workers
by Elucidation of Molecular Mechanisms of Body Clock Homeostasis
Department
Pathological Treatment for Shift
Workersof Systems Biology
Graduate Schoolof Pharmaceutical
Sciencesby Elucidation of Molecular Mechanisms
of Body
Clock Homeostasis

Training Program of Leaders for Integrated Medical System
for Fruitful
Healthy-Longevity
Department of Bioinformatics
and Chemical
Genomics Society (LIMS)
1st grade
Graduate School of Pharmaceutical Sciences

Kumiko Dojo

Kumiko Dojo

(1) What I have learned throughout this year
In the 21st century, the population of shiftworkers and midnight workers is increasing.
According to the survey by the Ministry of Health, Labor and Welfare in 2007, 27% oflaborers are working as shiftworkers and midnight workers. Due to rotating shiftwork andwork at midnight, phase relationships between internal circadian rhythms and the external
day/night cycle are unfitted. Shiftworkers have the increased risk of dyslipidaemia,
hypertension, diabetes, and vascular disease1-4. Elucidation of the causes of pathologicaltreatment for shiftworkers and treatment for them have not been taken into action.
As starting my research, “the health risks of shiftwork”, I looked into the papers tounderstand what had been currently known/unknown of the relationship between
shiftworkers and shiftwork-related diseases. I also attended the 37th Annual Meeting of the
Molecular Biology Society of Japan and learned cutting-edge studies of chronobiology
related with shiftworker-related disease. For example, shiftworkers have higher possibility
to get cancer. Breast cancer has been extensively researched on this issue. Women who are
older than 50 and have worked as shiftworkers for more than three years have more risks to
get breast cancer by 4.3 times. It is said that lack of melatonin which is secerned at nightleads to cancers5. Another group reported relations between forebrain and depression. The
mouse anxiety-/depression-like behavior is significantly perturbed in mice which lackcircadian rhythmicity of clock genes in the forebrain and jet-lag halts rhythmicity of clock
gens circadian rhythm. Therefore, shiftworkers perturbed themselves’ oscillation pattern ingene level. Throughout this year, I got the newest information of jet-lag and shiftwork.
(2) Future Plan
The aim of my research is to reveal the cause of high-risk shiftworker-related disease at
the molecular level, and to develop a novel way to prevent it. As a model of shiftworkers,
there is an experiment that mice are settled in a chronic jet-lag. For example, Davidson
reported that half of old mice died after one month under 6 hours jet-lag environment every85

4 days compared to the few dead young mice5. Although this experiment is very interesting,the cause of death has not been revealed. Therefore the coping ways were not mentioned
either. One of the reasons preventing advancement in this field was the difficulty to develop
mice lacking jet-lag symptoms, and thereby it was hard to compare with wild mice, and to
specify causes of diseases. In 2013, the laboratory I am currently attending reported thedevelopment of a mouse model (V1aV1b double knock out mouse; V1aV1b DKO) whichlacks symptoms of jet-lag in both advancing and delaying ways. When imitating the jet-lag
situation, wild type mice need 10 days to reentrain themselves to the new light/darkenvironment. On the other hand, V1aV1bDKO mice reentrained immediately to the newenvironment. As the annual goal for next year, I am going to put wild type mice andV1aV1bDKO mice under chronic jet-lag condition for a while and search how clock genes’
and metabolic genes’ expression at suprachiasmatic nucleus (SCN) and peripheral organs
change, and whether V1aV1bDKO mice live longer than wild type mice. As analyzing thesesignal transduction, I would like to develop compounds to prevent the death of wild typemice under chronic jet-lag. The achievement of this study will lead development of
medicine which prevents especially elderly shiftworkers to get shiftwork-related diseases.
I hope my research will serve as a hint to establish a fruitful healthy-longevity society.
References
1. An Pan et al. Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective
Cohort Studies in Women. PLoS Med 2011;8:e1001141.
2. Mirei Uetani et al. The influence of being overweight on the relationship between shift
work and increased total cholesterol level. Ann Epidemiol 2011;21:327-35.
3. Lieu Sung J. et al. Rotating night shift work and disparate hypertension risk in AfricanAmericans. Journal of Hypertension. 2012. 30: 61–66.
4. Manav V Vyas et al. Shift work and vascular events: systematic review and metaanalysis. British Medical Journal. 2012; 345: e4800.
5. Davidson AJ et al. Chronic jet-lag increases mortality in aged mice. Curr Biol.
2006.16:R914–R916.

Annual Report
Department of Molecular Engineering
Graduate School of Engineering
Masatoshi Uno86

(1) Themes of research in LIMS Program“Prediction and validation of the onset mechanism of autoimmune disease
based on disorder in the cytokine network”(2) BackgroundNowadays, autoimmune diseases have accounted for a large proportion in incurable
disease groups designated by Ministry of Health, Labour and Welfare. Generally, they are
regarded as being caused by disorder of immune system, for example, systemic lupus
erythematosus, rheumatoid arthritis, scleroderma and so on 1. However, pathogenesis in the
autoimmune disease has not been elucidated and therapeutic strategies are remission by
symptomatic treatment. One disease of the largest number of patient in autoimmune diseaseis rheumatoid arthritis (RA) and there are 0.7~0.8 million patient of RA in Japan. Main
symptoms of RA are inflammation in the joints and joint deformation caused by inflammation.
Recently, a researcher found signaling molecule in Osteoclast differentiation system calledRANKL 2. Osteoclast is key factor of joint deformation and RANKL is involved in immune
signaling molecular system. These results suggest that RANKL contributes joint deformation.
In fact, medicines of anti -inflammatory cytokines antibodies (anti-TNF-α,anti-IL-6) weredramatically effective. But, there are no medicines which can effect all patients and cureradically. So, development of eradicative medicine of RA has been expected.
(3) Study
Purpose of this research is analysis of RA’s molecular mechanism for suggestion oftreatment method. So I focus on molecular network of cytokines in RA, and I am going toconstruct its simulating system. Moreover I am going to evaluate effect of single nucleotide
polymorphism in genome-wide association study and search treatment target with thissimulating system. Similar researches have existed, but most targets of these researches arecancer3. So I aim to construct a simulation system that targets the cytokine system with afocus on IL-6 system which involved in RA strongly and other autoimmune diseases in thisstudy. It is another goal to reflect the simulation system by biochemically evaluating a change
by SNP found simultaneously genome analysis.
(4) Reference
1.
Ueda, H. et.al Association of the T-cell regulatory gene CTLA4 with susceptibility to
autoimmune disease. Nature 423, (2003)
2.
Takayanagi, H et.al T-cell-mediated regulation of osteoclastogenesis by signallingcross-talk between RANKL and IFN-g. Nature 408, (2000) .
3.
Oda, K. & Kitano, H. A comprehensive map of the toll-like receptor signaling network.
Mol Syst Biol 2, (2006).

87

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Graduate School of Engineering,WDUX 7DNHVKLWD
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88

Development
Optical Materials
Materials Based
Based onon Organic
Organic –Development ofof Functional
Functional Optical−
InorganicHybridsforQuantitative
Detection
ofBiomolecules
Inorganic Hybrids for Quantitative Detection of Biomolecules
Department of Polymer Chemistry
Department of Polymer Chemistry
Graduate School of Engineering
Kazumasa Suenaga Graduate School of Engineering
Kazumasa Suenaga(1) Development of chemosensors with aggregation-induced emission-active polymers
We develop the stimuliresponsive
chemosensors
based on the emissive
polymers (Figure 1). For
example, we report thermallyresponsive emission changes Figure 1. Chemosensors for evaluating protein cohesion.
of the water-soluble polymers
containing the aggregation-induced emission (AIE)-active organoboron dye. The polymers
composed of poly(N-isopropylacrylamide) (P(NIPAm)) were modified with the boron
ketoiminate dye which can show the AIE property. Before heating, the slight emission wasobserved from the solution of the synthesized polymers at room temperature. The bright green
emission was obtained from the solution by heating above 40 °C. The temperature-sensitive
emissive polymers can be prepared based on the AIE-active materials. In addition, we also
prepared the films with the AIE-active copolymers composed of fluorenes and the sulfidesubstituted boron diiminates and evaluated the changes in the optical properties by the oxidation.
By soaking the film samples of the polymer in the H2O2 solution, the significant increase of theemission intensity was observed by oxidation. The quantum yields increased up to 3-times
larger by oxidation at the sulfide groups. This would be attributed to the facilitating chargetransfer (CT)-emissive fluorescence between the fluorene units and the boron diiminates having
the enhanced electron-withdrawing ability by replacing from the sulfide to the sulfoxide groups.
These materials should be a suitable platform as a bioprobe for longitudinal monitoring the biorelated reactions.
(2) Development of mechanofluorochromic materials based on AIE-active complex
Mechanofluorochromic (MFC) compounds that show the switchable-photoluminescent
properties in response to mechanical stress have received a great deal of attention from both
fundamental research fields of solid state photochemistry and applications for optical devices
and sensors. However, there are few examples to offer organic MFC molecules because mostof the organic emissive dyes generally showed extremely-weak emission in the solid states by89

the concentration quenching. Therefore, there is still large difficulty in the development of MFC
compounds based on organic molecules. To overcome this problem, the AIE-active molecules
which show the strong emission only in theaggregation and solid states are promising
candidate. Indeed, some MFC materials withstrong solid-state emission have beendeveloped based on the AIE-active molecules.
We have presented opto and/or electronic
properties of the series of organoboron
complexes and polymers. In particular, someboron ketoiminate derivatives exhibited the
AIE properties, and highly-emissive solidmaterials were obtained. In addition, various
optical properties such as emission color andstimuli-responsiveness can be modulated by
the substituent effects. Next challenge is torealize the MFC properties based on the AIEFigure 2. a) UV−vis absorption and b) PL
active organoboron complexes.
spectra of BKM-H(a) and halogen-substituted
In this research, boron ketoiminates with boron ketoiminates in THF (c = 1×10−5 M). PL
MFC properties including a bithiophene unit spectra of BKM-H(a) and halogen-substituted
are presented. We synthesized a series of boron boron ketoiminates in c) crystalline and d)
ground states. e) Photograph of the boron
ketoiminates with various functional groups at ketoiminates in the crystalline and amorphousthe ends of molecules and investigated the states under UV irradiation.
relationship between the substituent effects
and the optical properties. Initially, we prepared a variety of boron ketoiminates andinvestigated the substituent effects on the optical properties by altering the end groups in thecompounds. It was found that the synthesized boron ketoiminates exhibited AIE properties. In
addition, MFC properties were also observed (Figure 2). Interestingly, the hypsochromic andthe bathochromic shifts of the emission bands were individually observed from boron
ketoiminates depended on the chemical structures of the end groups. From the X-ray diffraction
and differential scanning calorimetry analyses, it was confirmed that the MFC property of boron
ketoiminates should be derived from a phase transition between crystalline and amorphousstates. Notably, the direction of the peak shifts of the emission band can be controlled by
selecting the substituents. In particular, we found that the size of the substituents should be
responsible for the color changes in MFC behaviors. The direction of the peak shifts of theemission bands was controlled by the degree of the steric hindrance of the end group. Finally,
we demonstrated the dynamic and reversible controls of emission colors by the external stimuli.

90

Literature searchsearch onon thethe relationshiprelationship between
between age-related
age-related diseases
Literature
diseases inin thetheLiteratureelderly
searchontherelationshipbetweenage-relateddiseasesintheelderly andand thechemicalcompoundsthat
inducethemthe chemical compounds that induce themelderly and the chemical compounds that induce them

Department of Synthetic Chemistry and Biological Chemistry
Department
ofSchool
Synthetic
Chemistry and Biological Chemistry
Graduateof Engineering
Department of Synthetic Chemistry and Biological Chemistry
Hiroki Enno Graduate School of Engineering
Graduate School of Engineering
Hiroki Enno
Hiroki Enno

(1) Diabetes(1) Diabetes
There are two main reasons why elderly people easily get diabetes. One reason is that
There are two main reasons why elderly people easily get diabetes. One reason is that aging
aging itself affects glucose tolerance badly. Another is that they have difficulty initself affects glucose tolerance badly. Another is that they have difficulty in managing their
managing their health by themselves, leading to diabetes as lifestyle diseases. Here, thehealth by themselves, leading to diabetes as lifestyle diseases. Here, the medicines for
medicines for diabetes whose physiological mechanisms are understood are summarized.
diabetes whose physiological mechanisms are understood are summarized.
1.1 Metformin
1.1 MetforminThis compound is transferred into liver cell by OCT1, which
This compound is transferred into liver cell by OCT1, which
impedes mitochondrial Complex I and suppresses
impedes mitochondrial Complex I and suppresses
gluconeogenesis in the liver. It is proposed that Metfolmin
gluconeogenesis in the liver. It is proposed that Metfolmin
Fig. 1 Metformin activates AMPK (AMP-activated protein kinase) andactivates AMPK (AMP-activated protein kinase) and
Fig. 1 Metformin
accelerates suppression of gluconeogenesis.
accelerates suppression of gluconeogenesis.
However, even for AMPK knockdown mice, theHowever, even for AMPK knockdown mice, thesuppression of gluconeogenesis is observed,
suppression of gluconeogenesis is observed,
which suggests there are other mechanisms
which suggests there are other mechanisms
involved.
involved.
Fig. 2 Mechanisms of Metfolmin
Fig. 2 Mechanisms of Metfolmin

1.2
1.2

Sulfonylurea
Sulfonylurea
Sulfonylurea, which has sulfonylurea functional group in its structure, can bind to
Sulfonylurea, which has sulfonylurea functional group in its structure, can bind to
the potassium channel SUR1 subunit and close the channel. This induces thethe potassium channel SUR1 subunit and close the channel. This induces the
depolarization of cell membranes and the inflow of calcium ion into the cell. This
depolarization of cell membranes and the inflow of calcium ion into the cell. Thismechanism finally leads to insulin secretion.
mechanism finally leads to the insulin secretion.

Fig. 3 Sulfonylurea
Fig. 3 Sulfonylurea

Fig. 4 Mechanisms of Sulfonylurea
Fig. 4 Mechanisms of Sulfonylurea

91

1.3

Meglitinides (glinides)
The reaction mechanism of meglitinides is almost thesame as sulfonylurea even though meglitinides do nothave sulfonylurea functional group. Meglitinides bind tosulfonylurea receptor with weaker affinity compared tosulfonylurea so the amount of insulin secretion remains
the same even after a meal.

Fig. 5 Meglitinides (Glinides)

1.4

DPP-4 inhibitor
DPP-4 inactivates incretin, which
promotes insulin secretion. DPP-4
inhibitor suppresses DPP-4 and increases
endogenic activated incretin concentration
to decrease the blood sugar.
Fig. 6 Mechanisms of DPP-4 inhibitor

1.5

SGLT-2 (sodium-dependent glucose transporter 2) inhibitor
SGLT-2 locates around proximal convoluted tubuleand resorbs 90% of glucose after the filtration ofglomerulus. SGLT-2 inhibitor interrupts theresorption by SGLT-2 and exhausts glucose into theurine, which reduces blood sugar.
Fig. 7 Mechanisms of SGLT2 inhibitor

1.6

α-glucosidase inhibitor
α-glucosidase is an enzyme to hydrolyze α-1,4-glucosido bond in sugar andaccelerates the absorption of the sugar. α-glucosidase inhibitor suppresses thissystem and prevents blood sugar from increasing.

Fig. 8 Ș-glucosidase inhibitor

92

(2) Alzheimer’s Disease (AD)Amyloid cascade hypothesis is one of the famous disease-developing mechanisms.
Amyloid β (Aβ) protein and tau protein are widely accumulated on the brain of thepatients and regarded as the cause of AD. However, the mechanisms and the cure are still
under investigation. So here the treatments that are relatively well-known as well as
medicine currently being developed are summarized below.
2.1

General medicine
In general, Cholinesterase (ChEl) such as donepezil and galantamine is used forpatients with early stage AD. This ChEl inhibits acetylcholinesterase and increases
acetylcholine. The binding site for Galantamine on the acetylcoline receptor isdifferent from that for acetylcoline, and Galantamine binding reinforces the effectsof acetylcoline binding to the receptor.

2.2

For middle stage AD patients, NMDA receptor antagonist is used additionally. This
blocks NMDA open channel and improves a signal-noise ratio of
neurotransmission.
Aβ immunotherapy
Active immunity: AN1792 vaccine caused autoimmunity meningitis for 6%
administrated group and so the phase II trial was canceled in 2002. Even though adecrease of the senile plaque was observed, the same degree of cognitive decline
was observed as in the placebo group. Currently three vaccines (ACC-001,
CAD106, UB311) are in phase II trial.
Passive immunity: Solanezumab, which recognizes an epitope from the 13th to 28th
amino acid in the Aβ protein, has a high affinity to Aβ oligomer. Although this did
not pass the endpoint of phase II trial, the suppression of cognitive decline wasobserved when compared to the placebo group.

2.3

γ-secretase activity inhibitorγ-secretase cuts not only APP (amyloid precursor protein) but also an aspartic acidprotease, a membrane protein complex and an amyloid precursor peptide, which
produces Aβ. One of the γ-secretase activity inhibitor, semagacestat, was expected
to inhibit γ-secretase and proceeded to phase III trial. However, the trial wascanceled because it caused cognitive declines and skin cancers.

2.4

BACE1 (beta-site APP cleaving enzyme 1) inhibitor
A673T, which was characterized as a genetically protective factor to AD, isregarded to suppress the BACE1 and inhibits outbreak of AD. Now one of the
BACE1 inhibitor, MK-8931 is in phase II/III trial.

2.5

Aβ coagulation inhibitor
Scyllo-inositol is regarded as Aβ coagulation inhibitor to making a nontoxic

93

complex with Aβ after passing through blood-brain barrier. Though significant
improvements of cognitive function were not observed, phase III trials are currently
being planned.
2.6

Tau-related medicine
Tau is considered to induce nerve cell death in amyloid hypothesis. One of the Tau
coagulation inhibitors, methylthionium chloride, was shown to suppress cognitive
decline in phase II trial.

(3) Cancer
In general, the risk of getting cancer increases with age. The symptoms of cancer are
unclear in the elderly compared to the young, so it is difficult to detect cancer at an earlystage. Here several kinds of efforts to cure cancer are summarized.
3.1

Radiation therapy
Generally speaking, cancer cells follow the Bergonie-Tribondeau’s law and havehigh sensitivity to radiation. However, when metastasis occurs in the early stages ofcancer, the survival rate of the patient is low even if local cancer cells are treated. Inorder to improve the radiation therapy efficiency, the following three methods arecommonly used.
[Oxygen effect]
Oxygen reacts with water under X-ray irradiation and produces reactive free radical
species, which enhances the reactivity of the cancer cells.
[Thermotherapy]
Thermotherapy affects hypoxic cells more than normal cells, which means that it
can selectively damage cancer cells. It can also compensate for the disadvantage ofradiation therapy because thermotherapy can give more damages to the cells in
S-phase which are less reactive against radiation therapy.
[Radiation sensitizer]
5-bromodeoxyuridine
This compound is similar to the DNA precursor “thymine” and can beincorporated to DNA and enhance radiation sensitivity.
Fig. 9 5-bromodeoxyuridine

misonidazole
This compound has high electron affinity and slower metabolic
speed than oxygen. So this compound easily reaches theFig. 10 misonidazole

94

hypoxic cells far from the capillary and enhances radiation
sensitivity.

3.2

Immunotherapy[Antibody production-inducing agent or supplements from outside]
1. Patients are vaccinated to produce antibodies against cancer in their body
2. Antibody against a specific cancer is made outside the body and vaccinated to thepatients.
[Reinforcement of natural immunity]
1. Natural products which activate immune systems are given to the patients.
2. Genetically modified proteins which activate immune systems such as NK
activation are given to the patients.
3. Lymphocytes of the patient are collected and incubated to reinforce NK
activation before they are given back to the patients.
4. Genes that activate natural immune systems are transferred to certain cells.
[Reinforcement of acquired immune system]
1. Compounds which are good for inducement and activation of cytotoxicity T
lymphocytes are given to the patients.
2. Adoptive immunotherapy
3. Genes that activate acquired immune systems are transferred to certain cells.
[Inducement of acquired immune system]
1. Cancer cells themselves or chemically modified cancer cells are given to patientsas vaccines.
2. Cancer-related antibodies are prepared artificially and given to the patients asvaccines.
3. Dendric cells are given to the patients to induce cancer-specific T cells in theirbodies.
4. Cancer-related antigen genes are transferred to the cells and induce cytotoxic T

3.3

3.4

lymphocyte.
Gene therapy
Viruses are used as a vector and immune-related genes are transferred to the cells.
In Japan, some gene therapies such as CG-CSF and interferon are being attempted.
RNA interference; RNAi
RNAi is a method to knockdown specific DNA using double-strand RNA. In
general, double-strand RNA induces the interferon response that reacts
nonspecifically to foreign genetic material in mammalian cells, so knocking down
DNA using RNAi was believed to be difficult. However, in recent years, it has been
discovered that short double-strand RNA can be applied to knockdown specific
DNA.

3.5

Molecule-targeted cure95

general, double-strand RNA induces the interferon response that reacts
nonspecifically to foreign genetic material in mammalian cells, so knocking down
DNA using RNAi was believed to be difficult. However, in recent years, it has been
discovered that short double-strand RNA can be applied to knockdown specific
DNA.
3.5

Molecule-targeted cure
[Molecular-targeted cure]This cure affects specific characters of cancer cells and controls the molecularabnormality which is essential to produce cancer cells. Expected goal of this cure is
not only eradication of cancer cells but also the symbiosis with cancers,
improvements of QOL and conditions of patients. However, there can be side
effects for molecular-targeted cure because of the crosstalk between each moleculein physiological conditions.
[Target molecules]
Every process such as self-duplication, apoptosis, DNA repair, histone
deacetylation, metastasis, differentiation, and vascularization is included. From amolecular functional point of view, the targets can be divided into ligands, receptors,
intracellular signaling molecules, and drug transporters.
[An example of a successful targeted therapy]
Imatinib is used to treat chronic myelogenous leukemia. This
compound is developed from more than 300 synthetic analogs
which inhibit the abnormal tyrosine kinase only in cancer cells.

Fig. 11 imatinib(4) Reference᪥ᮏ⮫ᗋ Japanese Journal of Clinical Medicine 2013, No.11, vol.71
἞⒪ 2014, 6, vol.96
Rena G, et al., Diabetologia 2013, 56, 1893
Zhou G, et al., J. Clin. Invest. 2001, 108, 1167
Foretz M., et al., J. Clin. Invest. 2010, 120, 2355
Ashfield R. et al., Diabetes, 1999, 48, 1341
Zhang C. L. et al., Science 2009, 325, 2009http://dm.medimag.jp/imgs/column/8/i1.gif
Melander, A. Diabetes, 2004, 53, 151
http://www.sglt2.info/about/img/vol02/ph_03.gif᭶ห⢾ᒀ⑓ 2013, No.12, vol.5⪁ᖺ་Ꮫࠊ2014, No.52, No.7
་⸆ࢪ࣮ࣕࢼࣝ 2012, No.8, vol.48
་Ꮫࡢ࠶ࡺࡳ 2013, No.5, vol.247⒴࡜໬Ꮫ⒪ἲ 2011, No.10, Vol.38
ࡀࢇࡣ࡞ࡐ࡛ࡁࡿࡢ࠿ ᪂࣭ࡀࢇ་Ꮫධ㛛㸰㸹㇂ཱྀ┤அ࣭ᮡᒣ἞ኵ࣭ᯇᾆᡂ᫛࣭୕ၿⱥ▱㸦⦅㞟㸧, ୰ᒣ᭩ᗑ㸪1996 ᖺ17) ࡀࢇ◊✲ࡢ࠸ࡲ ࡀࢇࡢデ᩿࡜἞⒪㸹୰ᮧ♸㍜࣭✄⃝ㆡ἞㸦⦅⪅㸧
㸪2006 ᖺ18) ᪂࣭ࡀࢇ་Ꮫධ㛛㸱 ࡀࢇࢆ࡝࠺἞ࡍ࠿㸹㇂ཱྀ┤அ࣭ᮡᒣ἞ኵ࣭ᯇᾆᡂ᫛࣭୕ၿⱥ▱㸦⦅㞟㸧ࠊ୰ᒣ᭩ᗑࠊ2008 ᖺ19) http://kusuri-jouhou.com/medi/cancer/imatinib.html
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96

2014 LIMS annual report2014 annual report
Department of Synthetic Chemistry and Biological Chemistry
Graduate Chemistry
School of Engineering
Department of Synthetic Chemistry and Biological
Graduate School of Engineering
Kyoto University
Nobuhiko Nishitani
Nobuhiko NISHITANIThe Aim of the LIMS program
The Training Program of Leaders for Integrated Medical System for Fruitful
Healthy-Longevity Society (LIMS) aims to produce medico-engineering students who canaddress the problem of the unprecedentedly rapidly aging society in Japan. The LIMS
students are required to understand the social needs in medical care and contribute to theestablishment of a fruitful society with people enjoying their long life and well-being.
In this program, it was possible to survey a whole range of medical and life support
systems. I realized that there were a lot of problems in hospitals or rehabilitation facilities,
and felt a need to propose a solution to them.
The first prize of the 7th Techno-Renaissance Japan
In the winter of 2014, I and four other LIMS students from different research fields won thefirst prize of the 7th Techno-Renaissance Japan. The Techno-Renaissance Japan is acompetition intended to promote inventions by combining the techniques of manufacturingcorporations and flexible ideas of science students. I thought that it would be a good
opportunity to form an idea into reality and decided to apply for the competition. I made up ateam with Ms. Aila JOHANNA (medicine), Ms. Tomoko MATSUMOTO (medicine), Ms.
Kumiko DOJO (pharmaceutical sciences), Mr. Hiroki ENNO (engineering). We proposed a
product to promote elderly people’s health and rehabilitation, and our idea received the firstprize.
The competition was organized by Nikkei, Inc, and this time, it was sponsored by five
Japanese manufacturing corporations: Three Bond Co., Ltd., Dai Nippon Printing Co., Ltd.,
Denso Corp., Toray Industries, Inc., and Fujimori Kogyo Co., Ltd. Each of them presented thecontest themes according to their corporate ideas and purposes. Our team chose Fujimori
Kogyo Co., Ltd. whose theme was “the future value of wrapping,” and we had a common
wish to design a product that has a new value of wrapping and helps people of all ages,
especially the aged, lead a vigorous and fruitful life.
Until now, material values, such as cost, benefit and efficiency, have been more important
than spiritual or emotional values in product development. In most hospitals and rehabilitation
facilities, they often provide only minimum equipment, mechanical instruments, and dreary97

rooms. However, we knew from lectures and study tours to clinics that both patients andhospitals really need more human-oriented instruments for treatment and rehabilitation.
In our product design, we focused on “walking” that is one of the most basic movements ofhumans. We proposed the idea that would make walking more pleasurable. Our idea is toincrease the motivation to walk by stimulating one’s curiosity and creativity. In medical
facilities, creative activities are often used to improve physical functions, and the motor
functions of handicapped children are made better by the playground equipment. In
rehabilitation programs, patients usually repeat monotonous and tiring movements. We
thought that our idea would be a good way to motivate the patients to walk. If walking
becomes fun, they become more active in their rehabilitation and more aware of theimportance of exercise. In the LIMS program, the project is underway to obtain a patent forour idea.
Moreover, if this idea is put to the widespread use in our society, more people will findpleasure in the act of walking and want to go out. Walking will increase their creativity, social
activities and communication, and it will finally result in revitalizing local communities. Thismeans that our proposal has possibilities in producing “a happier society wrapped in ouridea.”
Future cooperation with people from different fields
It was also good for me to have met with news media, manufacturing companies, andstudents from other universities at the competition and the award ceremony. Talking withpeople from business corporations, I realized that they need leaders who can make new
proposals. In this competition, I applied what I had learned, discussed with people fromdifferent research fields, and proposed new idea and value to the society. It was a very
valuable experience for me.
All of the subjects I learned in the classes of the LIMS program contributed to the successof our team: Human Anatomy, Physiology, Medical and Life Support Systems, Medical
Engineering for Society, and English Debate. I have learned the construction and functions of
the human body, the actual situations of hospitals
and rehabilitation facilities, and the history of thedevelopment of medical and therapeutic devices.
If any of these had lacked, we could not havesucceeded in shaping and proposing our idea. I
would like to appreciate the support from the staff
of LIMS, Fujimori Kogyo Co., Ltd, Nikkei, Inc.,
all the participants in the Techno-RenaissanceJapan, and my teammates.

98

Student Activity Report(M2 Students)
Genome information
information andand reducing
reducing medical
medical expenses
expenses
GenomeDepartmentof Anatomy
and Developmental Biology
Departmentof Medical
Science
Graduate School of MedicineGraduate School of Medicine
Maki Sakuma
Maki Sakuma(1) Oral presentation at 6th Bordeaux RNA Club Workshop
One of the components of the integrated medical system for super-aged society would
probably be genomic information. Sequencing individual genomes may tell us who ismore likely to get a certain disease, respond to drugs in a different way, and will be very
useful in planning each individual a personalized prevention plan for diseases andtreatment. In the super-aged society, prevention and efficient treatment to cut back onnational medical expenses are imperatives. With this in mind I did research in the field of
bioinformatics and dealt with data produced by next generation sequencers. My research
investigated the difference in response between human and mouse against a small
chemical compound TG003, which is a potential drug for Duchenne muscular dystrophy
for certain patients, in order to find the targeting sequence of the compound. Through this
we obtained the result that “weak exons” (exons that have fewer, shorter signals or signalsthat are far from the consensus sequence for its recognition) tend to respond more to
TG003, and with the support of LIMS, I was able to go to France and was selected toorally present my research to the audience of experts in RNA at 6th Bordeaux RNA Club
Workshop. The results presented at this conference have been expanded and were
submitted for publication in BMC Biology. This research was an invaluable experience inthat I was able to really see that difference in sequence indeed affects response to a drug
(we also did a cross-species transfection experiment to confirm that the difference
originates from difference in sequence and not cell environment). Although ourcomparison was between human and mouse and our main interest was to decipher thetargeting rules of a specific compound against rare diseases, the findings of our research
add further to the assertion that sequencing individual genome and understanding how
variants affect drug response is necessary for efficient use of medical resource.
(2) First prize in Sogo Rinsho Holdings Paper Competition on “Medicine in the age oflow birth rate and aging society”.
Attending LIMS program classes gives us the chance to explore current issues related tothe ageing society, and opens our eyes on where our own research stands in the whole
picture of our society. One of the classes I took that was directly related to thinking ofways to reduce medical expenses was medical economics. Through the discussions and99

lectures of this class, I developed my own opinion on how the medical expenses should bemanaged in Japan and submitted this paper to Sogo Rinsho Holdings student paper
competition, and won first prize at the student competition.
http://www.sogo-holdings.jp/ronbun/(3) Leaving the program
Participating in the LIMS program has been an incredibly supportive and intellectuallystimulating experience for me. Discussing with fantastic researchers not necessarily
related to my field, getting their feedback in my career and research, and attending
lectures of different discipline on regular bases and occasionally would have otherwise
been very difficult. However, after being in the field of research and completing themaster’s program, I came to the conclusion that becoming a medical doctor would
maximize my potential in contributing to building an integrated medical system for thesuper-aged society, and hence with sincere gratitude to all the members of the program I
decided to leave the program. Thank you again very much for your support.

Activities
in LIMS
LIMS Program
Program
Activities in
Departmentof Human Health Sciences
Department of Human
Health Sciences
Graduate School of MedicineGraduate School of Medicine
Mikako Gomyo
Mikako Gomyo(1) Introduction
I have finished my second year of LIMS program in this March. Since I decided to
study at LIMS program, I have experienced many things involved in my research activities.
LIMS provides us with the opportunity to investigate another research theme, learn manykinds of subjects, and have a supervisor and mentors to consult on every topic. I reallyappreciate much cooperation of all people involved in this program.
In this section, the outline of this report is described as follows. In section 2, themotivation for LIMS program research is mentioned. I have two LIMS research themes as achallenging photoacoustic subject and a clinical issue of ultrasound, and the current courseof the second one is introduced in section 2. Section 3 presents the progresses and prospectsof photoacoustic examinations. Section 4 states my experiences I learned from various
classes in LIMS and an international conference.

100(2) Research Theme for LIMS program
I have learned medical subjects in my school from the clinical point of view. I entered
my laboratory in the beginning of fourth grade in the undergraduate course and started mychallenging photoacoustic subject and a clinical issue of ultrasound, and the current courseof the second one is introduced in section 2. Section 3 presents the progresses and prospectsof photoacoustic examinations. Section 4 states my experiences I learned from various
classes in LIMS and an international conference.
(2) Research Theme for LIMS program
I have learned medical subjects in my school from the clinical point of view. I entered
my laboratory in the beginning of fourth grade in the undergraduate course and started myresearch about ultrasound. I was fortunately assigned the theme aiming at clinical use as I
had wished. While I have been content with my research and tried hard, I got interested inother devices for diagnoses by gathering much information related to medical imaging.
Meanwhile, since I began to study the basis of ultrasound after joining the laboratory, I
had been tough on studying the basics of physics and computer mathematics while sparing
time to read papers involved in the latest ultrasound researches. LIMS program mysupervisor introduced attracted me on the issue both of research and of study.
My research purpose is to improve quality of life for all people by finding diseases inmuch earlier stages. I would like to research in this program especially for the elderly
people because I engage in the research for the female or life-related diseases. Since I am
also interested in the research objects which are different from my research about
ultrasound in my laboratory, LIMS program is suitable for me and provided a great
opportunity to manage my new interest. I considered many ways and devices to seek thefeasibility of enhancing health of the diseased and aged over much discussion with mymentors in LIMS and supervisors in my laboratory. I finally selected photoacoustic
technology as the theme for LIMS program to diagnose the elderly earlier and titled asfollow: “Quantitative assessment of photoacoustic properties of biological tissues byphotoacoustic microscopy”. The safety and effective method used in clinical practices andcare facilities is sure to enhance quality of life for each person in this aging society withincreasing patients and medical costs.
I set the clinical theme as the second research theme for LIMS program: “Applying
viscoelastic properties for pathology and other clinical diagnoses”. I proposed the methodof mapping viscoelastic properties, and it is applied to human tissue mimic phantom madeof agarose and gelatin at the moment. In the course of determining viscoelastic propertiesof each phantom, I obtained opportunities to give presentations or to be adopted in theannual conference of the Japan Society of Ultrasonics in Medicine and other threeconferences from May 2014 to February 2015. I am going to establish validity of the
proposed method and to demonstrate on extracted human organs or tumors for pathology
or other clinical diagnoses.
(3) Research Progress in LIMS
Photoacoustic technology means the fusion technique of optics and acoustics andenables to take both advantages of optics and acoustics that are functional imaging andmeasurement depth respectively. At present, photoacoustic technology is under study andhas not applied to clinical use. I attempt to seek what kind of challenging problems
remains. Many researchers involved in photoacoustic technology have graduated with adegree in engineering, and then my medical point of view can be effective for solving thechallenging problems.
In many kinds of methods based on photoacoustic technology, I focused on

101Research 63130-4899,
Progress in LIMSUSA, St. Louis, (3)Missouri
Photoacoustic technology means the fusion technique of optics and acoustics andauthor: lhwang@biomed.wustl.edu

enables to take both advantages of optics and acoustics that are functional imaging and21, 2010; accepted
February
3, 2011;At present, photoacoustic technology is under study andmeasurement
depth respectively.
Doc. ID 139968);
published
Marchuse.23,
2011 to seek what kind of challenging problems
has notapplied to clinical
I attempt
remains. Manymicroscopy
researchers involvedin photoacoustic
technology have
solution photoacoustic(OR-PAM).
Incorporationof agraduated with adegree ofin engineering,and then my medicalof viewby
can 18:4
be effectiveon the sensitivity
our first-generation(G1)point
systemdB, for solving the
problems.
mm at 570 nm.challenging
Moreover,translating the imaging head instead of
In many kinds
methods
basedwithinon photoacoustic
by a factor of 5, widening
the offieldof view
the same technology,
acquisi- I focused on
th intact craniums,
were Microscopy
imaged invivotoindemonstrate
both totalitsconcentration
Photoacoustic(PAM)
availability for clinical use in the
Optical Society
Americanearoffuture.
Photoacoustic tomography, for example, has been used to examine cerebral
vasculature (Fig. 1) and oxygen saturation of mice (Fig. 2) and is under clinicalinvestigation [1, 2]. PAM has especially higher resolution compared with otherphotoacoustic technology such as photoacoustic tomography [3], and therefore I adopted
Thebeam isproperties
attenuatedby aI designed
neutralfilterAM),
it to filteredelucidate photoacousticof human tissue.
and density
assembled PAM
inthe experiment room. Since
I did not haveany knowledgeof the into
photoacoustic
field, I(NDC-50C-2M,
Thorlabs)
andlauncheda singleogenlooked up
many coupler
literatures and(F-91-C1,
selected the basic
design of PAM.The
It wasoutput
based on the
mode
fiber
Newport).
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2008
thesingle-mode
fiber(P1-460A-FC-2,
Thorlabs)2008
is collienous
microscopy (OR-PAM) (Fig. 3) [3], and modified for our laboratory’s space to be as small
matedby a microscope objective (RMS4X, Thorlabs),es [2]as possible (Fig. 4). Although currently most photoacoustic systems need large spaces toreflected
bythata thestationary
mirror,andback
aperoundplace, I assume
photoacoustic imaging
systemI willfills
work thefor should
be portable
tureof toanotherobjective
objective) toology
in orderbe effective identicaleven in small clinics
or nursery (imaging
houses for the future.

I ordered nearly
and assembled
each part of PAM I designed,opticaland some offocusing.
them beyond theAachievediffraction-limited
n ourbudget sampler
were borrowed
from my belonged
laboratory andand willbe purchased the next
beam
(BSF05-A,
Thorlabs)a photodiodearecomsemester. During the course of assembling, there were some problems that assembling
inserted between the collimation objective and ther, thewas difficult because of precise adjustments and components ran short and needed custom
stationary
mirror to monitor the fluctuation in laser
FOV)
orders due to the design amendment. I have learned many lessons from these processes
intensity.
the G1
OR-PAMsystem (solidating
L Edesigning,
T Different
TER
S fromincludingordering,
and assemblinga deviceas my first experience.
boundary inset in Fig. 1), where two right-angle prisms
gh to
sandwich a thin layer of silicone oil for acoustic-opticaleportcoaxialreplaces the lower Figure 3 F
d deba alignment [6], G2 OR-PAM
rat
0.95
0.95
4
4
right-angle prism with a rhomboid
Ed- Dawley
M, we
1 prism (NT49-419,
1
were empl
mund Optics) to enhance the detection sensitivity (as0.85
dis- acquired a
which
0.85
cussed later). An acoustic lens [numerical aperture(NA): squares fit
he G1
5
5
2
2
color bmputedmputed tomography.
tomography. (a)(a) SpherSpher0.75
0.75
3
3
0.5]
is ground in the bottom of the rhomboid
and thellows
1prism,
1
mm
mm
ng
ng
measurement,
measurement, ananultrasonicultrasonicvenules (bvesvesphotoacoustic
photoacoustic
signals
signalsemitemitprovides
an acoustic focal diameter of 43 μm at the and-gelatin
bject,
ction, aa quantity
ction,
quantity related
related to
to c
the
the
d
suspension
A
Aultrasonic
dd via
via asaa spherical
spherical 50
surfacesurface(notvivo central
(not
4
4
MHz
frequencyofFig.2
thetransducer
ast
Fig.1
In
PAT
rat brainacquired.
Functional
imaging of saturation
O in vivo in
1 images of1guration.
guration.
numbered
Differential image of before and after three
a rat. Four different images were acquired by(V214-BB-RM,
Olympus-NDT).
The
optical(578andg thesequential administrationsof nanoshells. Field
four wavelengths
nm, 584acoustic
nm, 590 nm
vessels wi: differential
Fig.
6.20 mm;
In vivo
vivo
PAT
images 5
ofoptical
rat
brain
acquired.
(a)nm)
Beforethree
sequentialsO values
In
imagesaa ratbrain
acquired.
(a)
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20 !6.
"APAT
and 596and three
the calculated
5offoci arealignedconfocallytomaximizethedetection
sennning
respective
2
2
absorption.
[1]
are
shown
in the color
bar. [2]administrationsof3nanoshells. (b)(b) ∼20 min
min after
after
three
sequential
administrations
administrationsofsequential
administrations
3nanoshells.
V
Vthreelocation mof nanoshells.
nanoshells.
(c) Differential
Differentialimage= b − a). Field
Field ofof view:view:
20
20 mm.
mm.
of
(c)
image
20
t are
sitivity. The
acoustic
is (c(csubmerged
in 20
a ×water-filled
1lens
1
mm
mm
differential optical
optical absorption.
absorption. (d)(d) Differential
Differential
Ae, optical
optical absorption;
absorption; ∆A e ,, differential
Ae,
distinguish(e.g.,
signal versus
signalversus time.
time. Adapted
Adapted with
with permission
permission fromfrom [43].
[43].

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ngth-102
mped

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e

the skinskin surface
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fPAMlaser
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blood
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laser
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photoacoustic
waves
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waves
are
in
head.
evaluate
individualsO2 transducer
levels.
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unfocused
ultrasonictransducer(XMS-310, Panametrics)
Panametrics)
An
unfocused
ultrasonic(XMS-310,
fPAM was first validated by measuring the sO of bovine blood

waveleng
However,fundamene© 2006 Nature Publishing Group http://www.nature.com/naturebiotechnology© 2006 Nature Publishing Group http://www.nature.com/naturebiotechnolog(V214-BB-RM,
Olympus-NDT).
optical(578transducer
andg fastthe asonstruction,a quantity
relatedto c
the central
administrationsof nanoshells. Field
fourwavelengths
nm, 584acoustic
nm, 590 nm
d theTheas
50 sequentialMHzfrequencyofultrasonicvesselswisuspensionof 20
A
ckward via a spherical surface(not4: differential
optical
Fig.
In
vivo
PAT
images
of
a
rat
brain
acquired.
(a)
Beforesequentialof view:
20 !6.120 mm;"AƗ§ɓƚ,@T|O
and 596nm)
and three
the calculatedsO values
Fig.1t^aǙ®ǥǁ.
PAT
Fig.2
t^a.ȩǄɉØĔƗ§ɓɗ&.ſȯ
5
arealignedconfocallyto maximize
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numbered
1–5, mabsorption.
[1]
are
shown
in
the590color[2]administrationsof3nanoshells. (b) ∼20 minThe
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ofalignednanoshells.
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acoustic
isbraininsequential
a ×water-filled
scanning
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detection
1lens
mmof a rat
Fig.
6.
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vivo
PAT
imagesacquired.
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5
Ae, opticalabsorption; ∆A e , differential optical absorption. (d) Differential
distinguishrespectively.
(d) H

2
administrationsof3nanoshells.
(b) ∼20
minafterVthree sequential(e.g.,
that aresitivity.
The
acoustic
lens
issubmergedawater-filled
signalversustime.
Adaptedwithpermission
from [43]. inadministrations
location marked w
of nanoshells. (c) Differential
image (c = b − a). Field of view: 20 × 20 mm.

1 mm
Ae, optical absorption; ∆A e , differential optical absorption. (d) Differential
ng (e.g.,
distinguished by2esignal versus time. Adapted with permission from [43].

the skin surface to conform to the ANSI standards [39]. UponngthfPAMlaser
can excitation,
pinpoint individual
blood
vesselswith highresolution
photoacoustic
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are producedin thehead. and wavelengvelengththeskin individual
surface to conformto the ANSI standards [39]. Upon
evaluatetheirsO2 transducer
However,levels.
mped
Ancan
unfocused
ultrasonic(XMS-310,
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fPAM
pinpoint
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fPAM
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evaluate
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dye laser∼6dB
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at bloodgle or16
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sO
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motor
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transducer
the acquisition
brain with atime
radius
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.
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data
to
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3
cm
and
a
step
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of
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tem
for
small-animal
imaging.
can furthe
variation in sO
of 1%.
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was thenusedtheto imagethe staticsO2 of array real-time
uning
hAT systemtuningsubcutaneous
vessels
inslice
normoxia,
wheremeasured
photoacoustic
The dataacquisitiontime
to obtain
3 cm anda2 step
sizeof 1.5is◦ .∼24for small-animal imaging.
asingle
2-D
image
min
at
this
pulse
repetition
rate.
real-time fPAM
subcutaneous
vessels
inslice
normoxia,
wherethisthepulse
measured
photoacoustic
7 ns)
a single
2-D blood
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is ∼24min atrepetition
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mply
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to improve
hyperoxia,
theimagedsO2 levels
in Prism
venousbloodtheincrease basic research.
transducernsand(ND6000,
a pulse repetition
pendicular
to resolution.
the imaging
plane
can
be andusedarterial
toimprovetheincrease basic res
hyperoxia,
imagedsO2 ±levelsinPrism
venouse laserContinuum).
out-of-plane
In0.016,
addition,a cylindricalscancanblood
beindicate
by 0.036±the0.031
and 0.012
respectively.
These
resultsrbe(ND6000,
resolution.
addition,a cylindricalscanresults
can beindicate
imaged isContinuum).
immobilizedon out-of-planetaken
to form
a 3-D
image
with
betterout-of-plane
resolution.
bythat0.036± 0.0310.012±In0.016,
respectively.
These
fPAM
can andpotentially
image
brain
functionsbased
on localmaged
is protrudes
immobilized
takenWetodemonstrate
form a 3-Dthe
image
withofbetter
out-of-plane
resolution.
e animal
intothataon
wa- fPAM
imaging
nanoshells(silicacore
diam- on local
Silicone
Object17
canpotentially
image
brain
functionsbaseddeoxygenation
following
intensive
neuron10–12
firing. whichOil
heof theinto
tank,where eter:
125 ± 5 nm;
gold
thickness:
nm),
serve
malbottom
protrudesa waWe Backward
demonstrate
the shell
imagingof nanoshells(silicacore
diammode
Silicone
17
Objectadeoxygenation
following
intensive
neuronfiring.
Oil of only B6
fPAM
is
safe
for
human
subjects
asitdeliversafluenceear polyethylene
as a125
contrast
agent
for PAT,inthickness:a rat in vivo10–12[43]. Twoofwhichthe PATserve
ttomof the tank,membrane.
where eter:
±
5
nm;
gold
shell
nm),
Backwardmode
2 atoftheaFig.
4 Diagram
OR-PAM
onhumanthe focus
backwardsubjects
mode. Almost
components
on
one
base
(grayedsquare)
for
even
for
transparent
samples.
This
fluencemJ/cm
fPAM
iscontrast
safe
forasallinrat
itdelivers
aTwo
fluenceof
only
B6
homogenized tomembrane.
provide relaimages
ofoptical
thecerebralcortex
of
the
brain
are
presented
inpolyethylene
as
a
agent
for
PAT,
in
a
rat
vivo
of
the
PAT
smaller
space and easy
to carry.
Lesslimitationof objects
such [43].
as thickness
forbackwardmode
2is 4well
4 Diagram
OR-PAMon mode.
thebackward
mode.
Almostbars
components
on2basebase(grayedsquare) for
2ofFig.
Fig.
of6(a)
onthebackward
mode.
Almostallallcomponents
on one(grayedsquare)forwithinthe
ANSI
safety
(20
mJ/cm
)one
in
the
spectralon Diagram
hich is lesstothan
10 Fig.
mJ/cm
and
(b),
where
the standard
color
arebrain
identical.
Withthecompared
toOR-PAM
forwardattheoptical
focus
even
for
transparent
samples.
This
mJ/cm
ogenized
providerelaimages
cortexofofoftherat
presented
influence
andtheeasy
to carry.Less
Lesslimitation
objectssuch
as thickness
for backwardmode
smallersmaller
space space
andof
easy
to cerebral
carry.
limitation
objectssuch
asare
thicknessfor backwardmode
2subcutaneous
regions
used
here.
An
in
vivo
volumetric
image
of
the
2is
comparedtoforwardmode.
well
withinthe
ANSI
safetystandard
(20
mJ/cm
)
in
the
spectralcomparedtoforwardmode.
ons less than 10 mJ/cm
Fig. 6(a) and (b), where the color bars are identical. With themicrovasculaturepalm
a human handwasMulti-mode
ﬁber acquired using
regions used here. ofAntheinObjective
vivo ofvolumetric
imageof the subcutaneous
lens
fPAM at Laser
584system
nm (Fig. 4).Objective
Total hemoglobin concentrationin the palm
Multi-mode ﬁberlens
microvasculature
of
the
palm
of
a
human
hand
was
acquiredusing(800 nm)
was imaged
withaqualitycomparable
to
that
in
the
aforementioned
Laser system
fPAM
at 584(Fig.
ﬁlter Total
Fiberhemoglobin concentration in the palm
Trigger
(800nmnm)
animalstudies.
TheND 4).
largest coupler
vessel in the imagePhotois B350 mm indiode
ND ﬁlter comparable
Fiber
was
imaged
with
to
that
in
the aforementioned
Oscilloscope
Triggera quality
diameter,(Data
whereasPhoto (50 mm). The
2
Beamone pixel
coupleris within
Acquisition) the smallestb
diodesamplerOscilloscope
animalstudies.
The
largestvessel
in
the
image
is
B350
mm
in
average ratioof the vessel to the backgroundin photoacoustic signal
Beam(Data Acquisition)
samplerdiameter,is within
one pixel(50is 51mm).
amplitudewhereas
is 35 ± 2,theandsmallest
the averagecontrast-to-noise
ratio
dB. Theb1
Ampliﬁer
Althougha 1D
forAmpliﬁer
atosingle
B-scan image intakes
only 10 s, a 2D
averageratio ofthescanvesselthePrismbackgroundphotoacoustic
signalscan over is
an35
8-mm-by-8-mm
area takescontrast-to-noise
more than 18 minratio
for singleamplitude± 2, and the average
is 51 dB.
Prism
Although a 1D scan for a single B-scan image takes only 10 s, a 2D
Siliconescan over an 8-mm-by-8-mm area takes Object
more than
18 min for singleOilmodeof the total hemoglobin
Silicone
UltrasoundFigure 4 Forward
In vivo imaging
concentrationin
ObjectOiltransducer
Forwardmode of the palm of a human hand Ultrasoundsubcutaneous
vasculature
by fPAM at 584
transducer
Fig.
5
Diagramof
OR-PAMontheforwardmode.
Measurementforstrongersignalto backward
nm. (a) Photograph of the imaged area. (b) MAP image of compared
the photoacoustic
mode due to placing ultrasound transducer underneath an object.
Fig.
5 Diagram
OR-PAMon the forwardmode.
Measurement
for stronger
signalthe
compared
to backward
signalsthestratum-corneum
layer
projected
along
z axis.
Figure4 below
Inofvivo
imagingof thetotalhemoglobin
concentrationinmode due to placing ultrasound transducer underneath an object.
(c) B-scan image
in the z-xofplaneat the oflocation
indicateddashedsubcutaneous
vasculature
the palma humanhand bybythefPAM
at 584
line
in
b.
The
skin
surfaceandthestratum
corneum
as
well
as
blood
vessels
nm. (a) Photograph of the imaged area. (b) MAP image of the photoacoustic

Skin surface

c

103
1

Skin

Fig. 5 Diagram of OR-PAM on the forward mode. Measurement for stronger signal compared to backwardmode due to placing ultrasound transducer underneath an object.

I could start to experiment after assembling, and I checked whether each component
worked well step by step as shown in Table 1. During the course of components tests, I
designed the forward mode (Fig. 5) to assess ultrasound transducer ability to receive
photoacoustic signal. Since it is necessary for the forward mode to set a transducer
underneath an object, objects should be thin enough to reach sound signal for thetransducer. This mode has an advantage to neglect the refraction rate and attenuation ofprisms. Although the forward mode does not need prisms, in this case for the backwardmode, prisms (with silicone oil for acoustic-optical coaxial alignment) were setup. The
results of no signal as a comparison and the forward mode are shown in Fig. 6 and 7,
respectively. While no significant signal could be observed in the control data with nolight signals, 22.26 mV peak-to-peak intensity was obtained in the forward mode data.
After that I found out on the backward mode (Fig. 4) the ultrasound transducer could
not acquire any sound signals derived from an object because a generated sound signal
seemed too weak. Some considerable causes are that the sound signal efficiency was not
sufficient to reach the transducer through prisms, an object whose light-to-soundconversion efficiency was much stronger should be used, and basically amount of light
was insufficient at the current value. Although I had tried to solve each cause in many
ways, sound signal could not be caught.

Table 1 Components tests of PAM
Components

Purpose / Operation(1) Fiber

1. Location of the first objective lens and fiber
Use laser pointer (visible light)
2. Strength through fiber
Set photodiode at the end of single / multi mode fiber(2) Light path(3) Ultrasoundtransducer(4) Objects(5) PAM signal

104

1. From the end of fiber to prism
Adjust location and distance between objective lenses
and prisms
2. From the end of fiber to photodiode
Adjust beam sampler

Results
Success
Single mode: in sufficientMulti mode: sufficient (>6 V)
Appropriate focus (3-4 V)
Appropriate refraction

1. Reception of soundUse another hydrophone to emit sound signal

Sufficient (1-40 mV)

2. Reception of photoacoustic signal
Set ultrasound transducer and object underneath prisms[Forward mode]

Sufficient (<30 mV)

1. Rubber of a syringe
2. Blackened synthetic resin

Weak (<1 mV)
Fair (<20 mV)

Set all components [Backward mode]No significant signals

0.06

INTENSITY (mV)

0.04
0.02
0

0.00E+00 1.00E-06 2.00E-06 3.00E-06 4.00E-06 5.00E-06 6.00E-06 7.00E-06 8.00E-06-0.02

TIME ( s)

-0.04
-0.06

Fig. 6 PAM data on the forward mode with interrupting laser path as a comparison experiment. No signals
after electrical noises from 0 s to 1.6 s.
0.06

INTENSITY (mV)

0.04
0.02

0
0.00E+00 1.00E-06 2.00E-06 3.00E-06 4.00E-06 5.00E-06 6.00E-06 7.00E-06 8.00E-06
TIME ( s)
-0.02
-0.04
-0.06

Fig. 7 PAM data on the forward mode. 22.26 mV peak-to-peak intensity from 1.8
electrical noises from 0 s to 1.6 s.

s to 2.6

s after

These results suggest that PAM I assembled can be valid for elucidating a
These results
suggestthatobject
PAM
I assembled
be whenvalid several
for elucidating
photoacoustic
property
of an
using
this forwardcan
mode
wavelengthsa
photoacoustic
propertyof anisobject
this forward
mode whenofseveral
wavelengths
aremodified andan object
movedusing
laterally.
After experiments
the forwardmode
are modified
objectis moved
laterally.
Afterbegin
experimentsof theforwardmode
success,
I willand
getan
back
to thebackward
mode andto measuremorecomplicatedsuccess, Icompared
will get backthe backward
structureto thetoforward
mode. mode and begin to measure more complicatedstructurecomparedmode.
In the near
future,toI theplanforward
to inventthe equipment which is effective for early diagnoses
near
future,plan
toinvent
inventtheequipment
equipment
whichisiseffective
effectivefor
early
diagnoses
In thethenear future,
II plan
to
the
which
early
diagnoses
in
in In
the
medicalsites. At
present,
I consider
the photoacoustic
deviceIforassembletobe usedmedicalsites.
present,
I consider
photoacoustic
deviceI assemble
to be
used
the
medicalsites.
At At
present,
considerthethephotoacoustic
devicetowithbeusedinin thedermatology
becausesomeIkindsof dermatologicaldiseases
areI assemble
diagnosed
visiblein dermatology
becausesomekinds
ofexaminers.
dermatologicalare diagnosed
with visible
dermatology
some
kinds
of on
dermatologicaldiseases
are diagnosed
with visible
towillthetothe nakedbecauseeyeanddepending
Thisdiseases
safetyandeffective
methodto the eye
naked
eye
andof depending
on examiners.
This
safety withandeffective
methodnaked
anddependingonfor
examiners.
This
safetyandsociety
effective
methodwill contributeoncontributeon qualitylife
all people
in thisaging
increasing
patients willandcontributeon qualityof life inforthisall agingpeoplesociety
in thiswith
aging
society withincreasing
patients
andqualityofcosts.
life
for all people
increasing
patients
and medical
costs.
medicalmedical costs.

(4) Experiences in Lectures, Practical Classes, and Conference(4) Experiencesin Lectures,
Practical
andConference
I have learned
much morethings Classes,
than I had
expected
before joining LIMS program. I
I havelearnedmuchdiversified
more things
than I hadandexpected
before joining
have
desiredto obtain
perspectives
gain knowledge
aboutLIMS
whichprogram.
forms theIhave desired
to obtain My
diversified
and gainknowledge
about
which
basis
for my research.
hope forperspectives
LIMS has beenrealized
for this one
anda halfforms
year. thebasis
for myLIMS
research.
My hopehas been
realized andfor this
one interesting
and a half year.
Lecturesprovided
for forus LIMS
were fully
informative
highlyfor me.
Lectures LIMS
providedfor us were
fully
informative
andme
highlyinterestingme.
Furthermore,interactive
assignments
were
very
effective forbecauseI had toforcheck

105contribute on quality of life for all people in this aging society with increasing patients andmedical costs.
(4) Experiences in Lectures, Practical Classes, and Conference
I have learned much more things than I had expected before joining LIMS program. I
have desired to obtain diversified perspectives and gain knowledge about which forms thebasis for my research. My hope for LIMS has been realized for this one and a half year.
Lectures LIMS provided for us were fully informative and highly interesting for me.
Furthermore, interactive assignments were very effective for me because I had to checkhow much I could understand new fields for me from time to time. I could foundintellectual bases of especially physics and computer mathematics because these twoteachers gave me kind instructions for me in person when I asked them. These subjects arereally helpful for me in that the concept of tensor in continuum physics is essential for
improving 3D ultrasound system and that the technique of computer programming isalways utilized for my daily research. I have not had an opportunity to attend many
subjects we could take as a LIMS student such as medical economics or special lecturesby businesspersons.
Practical work courses attracted all participants including me. I could enhance myrecognition about current situations by visiting nursery homes and the facility for the latest
medical equipment. I was really interested in anatomy practice using the actual humanbody with the different background students. The greatest firsthand experience for me inpractical classes was to see surgery in operating rooms. The class aimed at treatment withfewer invasions than usual, which corresponds to my interest. I strongly felt that I would
like to go on researching and invent the medical device contributing to early diagnosis.
I could have the opportunity to attend the international optics conference, “SPIE
Photonics west”, held in U.S. and take workshops about informal presentation and paper
writing. It is said to be the largest conference involved in optics including photoacoustics;
there were 4,728 presentations and over 1,250 companies last year (a statistics of this year
has not published). I was really impressed with many latest and innovative reports, andthere were many contents for providing me with my research ideas. I have learned mainly
about the photoacoustic technology at the sessions of “Multimodal Biomedical Imaging”,“Optical Elastography and Tissue Biomechanics”, and so on. The measuring objects ofphotoacoustic technology appear to be expanding these years, and I got interested in theapplied technique for dermis as a clinical subject. Besides, I could have a talk with theprominent professor I met before in an international ultrasound conference, and I got toknow he was involved in the fusion technique of optics and ultrasound as well and felt agreat potential in the fusion technique like photoacoustics. In the whole-day workshop, thelecturer who has published several books about academic presentation and writing
provided us with interactive discussions. I could make fellows who belong to SPIE
student club, and we promised each other that Kyoto University would join the student
club next time. Therefore I have a keen desire to go back to the conference again with mypublication related to photoacoustics. All things in this conference highly motivated me
for LIMS program.

106

Acknowledgements
I wish to express my sincere thanks to profound gratitude to my LIMS supervisor Dr.
Masakazu Toi, Professor of Graduate School of Medicine at Kyoto University, and mystudent club, and we promised each other that Kyoto University would join the student
club next time. Therefore I have a keen desire to go back to the conference again with mypublication related to photoacoustics. All things in this conference highly motivated me
for LIMS program.
Acknowledgements
I wish to express my sincere thanks to profound gratitude to my LIMS supervisor Dr.
Masakazu Toi, Professor of Graduate School of Medicine at Kyoto University, and my
LIMS mentors Dr. Masao Matsuhashi, and Dr. Takehiko Kinoshita, for their invaluableguidance, advice, supervision and constant encouragement during the course of thisprogram. I thank all members of Medical Imaging System Sciences Laboratory for theircorporation and great deal of helpful advice for my research work.
References[1] Y. W. Wang, et al, “Photoacoustic tomography of a nanoshell contrast agent in the invivo rat brain”, Nano Letters, vol. 4, pp. 1689–1692, 2004.
[2] H. F. Zhang, et al, “Functional photoacoustic microscopy for high-resolution andnoninvasive in vivo imaging”, Nature Biotechnology, vol. 24, pp. 1419-1421, 2007
[3] S. Hu, et al, “Second-generation optical-resolution photoacoustic microscopy withimproved sensitivity and speed”, Optics Letters, vol. 36, No. 7, pp. 1134-1136, 2011

What I have learned in the Master’s Program and what to do in the
What I have learned in the Master’s Program and what to do in the
Doctoral Program
Doctoral Program
Departmentof Molecular Pharmacology
Department of Pharmaceutical
Sciences
Graduateof PharmaceuticalPharmaceuticalSciences
Sciences, Kyoto University
Graduate School of
Jun Miyanohara
Jun MIYANOHARA(1) What I learned this year
Training Program of LeadersforIntegrated

MedicalSystemfor

Fruitful

Healthy-Longevity Society (LIMS) has started since September, 2013, to cope with
global-scale problems of an unprecedented aging society. It’s my great pleasure to havebecome a member of the training program. One and half a year have passed and even now
it seems difficult for me to study both in our laboratory and in LIMS. However, I haverealized what I gained in such a busy curriculum was very helpful for me to consider not
only medical problem around the world but also what I should be as a medical leader. In
that sense, it was very fruitful period in my master’s program. Here, I would like tointroduce some of classes and a LIMS research I have been doing.
One of the most impressive classes for me was human anatomy. In the class, I haveacquired extensive knowledge on human body by taking the lecture with students
majoring medicine. In addition, I could observe remains as a practice and for the first timerealize the beauty of the human body. I have been studying on pathophysiology usingrodents in graduate school of pharmaceutical sciences, and it seems very important for me
to know the differences between animals and human, which is sure to be useful for my107

only medical problem around the world but also what I should be as a medical leader. In
that sense, it was very fruitful period in my master’s program. Here, I would like tointroduce some of classes and a LIMS research I have been doing.
One of the most impressive classes for me was human anatomy. In the class, I haveacquired extensive knowledge on human body by taking the lecture with students
majoring medicine. In addition, I could observe remains as a practice and for the first timerealize the beauty of the human body. I have been studying on pathophysiology usingrodents in graduate school of pharmaceutical sciences, and it seems very important for me
to know the differences between animals and human, which is sure to be useful for myfundamental research.
We took the debate class following the previous year. The aim of the course is to improve
communicating one’s own ideas convincingly. Last year, English articles were provided
and discuss the matter and then presented in parliamentary debate style. I could learn how
to debate and improve our ability to form and express opinions in English. In contrast, thisyear, we practiced mainly the presentation on scientific proposals, such as how to get a
research grant.
I had been in trouble with what kind of research I had to do, however, finally I have started
a LIMS research since this year. I am looking forward to doing this study from next year.
(2) From next year
From next year I have to conduct researches both in pharmaceutical sciences and in LIMS
and it would be required to do plenty of work during the doctoral program.
Thanks to teaching staff, office workers, and my colleagues, I had a fruitful time during
my master’s program. I am looking forward to your ongoing support, thank you.

Annual report 2014
Department of Polymer Chemistry
Graduate School of Engineering
Rei Kuwabara
In this year, I developed subcutaneous islets of Langerhans (islet) transplantation by
implantation of cyclic peptide SEK-1005 (SEK) without immunosuppressive drug forinsulin-dependent diabetes treatment, and I researched the mechanism of immune tolerance.
Briefly, I prepared immune tolerance sites by implantation of agarose rods supplying SEK
under the skin. By transplantation of allo-islet into the site, long-term allograft islet survival
were accomplished without immunosuppressive drug, and almost of the recipient rats
demonstrated stable normglycemia over 100 days after allo-transplantation. In histologicalexamination (Fig.1), I demonstrated that insulin producing cells (allo--islet graft) were alive insubcutaneous tissue and islet grafts had functional vessels. Few immune cells infiltrated in and108

around islet-grafts. Today’s clinical islet
transplantation have three problems; 1) shortageof islet donor, 2) immunosuppressive therapy,
and 3) optimization of transplant site. Thismethod can resolve problem 2) and 3), andbecome successful method of diabetes treatment.
I had a patent application on the induction of
immune tolerance by SEK in this October.
Because I will apply for a patent of the Fig.1 Immunofluorescent staining for insulin
mechanism of immune tolerance by SEK, I (red) and nucleus (blue). Functional vessels
cannot show the mechanism in this report. I will stained by the perfusion of FITC lectin
put together a paper about the results of transplantation and this mechanism, and I want to carryout a clinical application with my research collaborators in the future.
In LIMS anatomy practice, I could touch real human organs and tissues and modestly
dissipate the dissociation between body parts of animals and human beings. This was difficult
for me only by reading anatomical chart. This practice was an amazing experience to give thehint to achieve clinical application of my research.
To extend my knowledge and report my research, I joined three conferences, the 36th annual
meeting of the Japanese society for biomaterials, the 6th Japan-Taiwan Nanomedicine
symposium, and the 14th congress of the Japanese society for regenerative medicine by using
Research Expense Allowance in LIMS. I would like to express my gratitude to this allowance.

Basic Studies
Studies andand Applied
Applied Medicine
Medicine
Basic
Departmentof Chemistry
Synthetic andChemistryandChemistry
Biological Chemistry
Department
of Synthetic
Biological
Graduate School of Engineering
Graduate School of Engineering
Takuto Suito
Takuto Suito(1) LIMS subjects
Two of the most impressive LIMS subjects in this year are “Geriatrics” and “Human
anatomy”. In Geriatrics, I learned a concept of the geriatrics and the therapeutics ofage-related disease. Aged-people have problems on both physically (e.g. sarcopenia) andmentally (e.g. dementia or depression). In addition, elderly people tend to have two or
more diseases simultaneously. Thus, there are particular problems in medical care ofelderly. So, they are needed comprehensive medical care, but there are not many
knowledge about them. I learned these situations about medical care of aged-people and I
can found the problems of medicines for fruitful healthy-longevity society.
The class of “Human anatomy” is the most impressive one. In this class, we learned109anatomy”. In Geriatrics, I learned a concept of the geriatrics and the therapeutics ofage-related disease. Aged-people have problems on both physically (e.g. sarcopenia) andmentally (e.g. dementia or depression). In addition, elderly people tend to have two or
more diseases simultaneously. Thus, there are particular problems in medical care ofelderly. So, they are needed comprehensive medical care, but there are not many
knowledge about them. I learned these situations about medical care of aged-people and I
can found the problems of medicines for fruitful healthy-longevity society.
The class of “Human anatomy” is the most impressive one. In this class, we learned
roles and function of human organs and motor functions through lectures and examinationof cadaver. Even though we had shorter time to learn anatomy compared with medical
students, but I thought I could learn the two main purposes of this class, one is theunderstanding of the 3D body structure and the other is acquiring the sense of
responsibility.
In this class, we observe the complex body structures and their individual differences,and I also understood the medical risks derived from these differences. When I wasundergraduate student, I majored in chemistry. In the graduate school I began to learn
biology but did not have a chance to learn anatomy. t I felt I spend a precious time to learn
practical knowledge of human body although I am not a medical student.
Through this class, I acquired not only a knowledge but also a responsibility as a
researcher of developing medicine. The cadavers that we had used in this class are
donated bodies and these donations are based on the expectations for the development of
medicine. In order to answer these expectations, I want to keep in mind the thing whichlearn from this class.
(2) LIMS research theme.
My research theme of LIMS program is “Study on gut commensal bacteria andage-related disease”. Recently, relationships of gut commensal bacteria and health of hostorganisms have been revealed including detail molecular mechanisms of them.
Metabolites of commensal bacteria and medicines which regulate the balance ofcommensal bacteria have attracted a great deal of attention of researchers as a novel
medication for some diseases. But the molecular mechanism of host-microbe interaction is
too complex to be solved. So, I use simple model systems to elucidate the host-microbes
interaction and their potentiality for medical applications. In this year, I achieved toestablish the model system of studying host-microbes interaction using Drosophila. Next
year, I want to research more details about age-related disease and commensal bacteriausing this model system.
Finally, in this year, I have tried to keep in mind the importance of fundamental
studies. All of medicines and other applied technologies are based on the fundamental
studies. Through the lectures and research of basic studies in LIMS, I will make effort tobe a medical developer who can find the seeds of research for the achievement of fruitfulhealthy-longevity society.

110Progress Report
Progress Report
Department of Synthetic Chemistry and Biological Chemistry
Graduate School of Engineering
Kazuma Yamaguchi
2015.03.26
ObjectNeurodegenerative disorder is a common name of progressive and incurable diseases that arecaused by neuronal death. In our aged societies, neurodegenerative disorder has become one of themost serious problems. Because the disease onset is late, and as a result of increasing elderly people,
there are many patients. Specific neurons die and patients lose the corresponding abilities; forexample, Alzheimer’s disease patients lose their ability to memorize because of hippocampus
degeneration. Spinocerebellar Degeneration (SCD) is one of the neurodegenerative diseases and
SCD is a generic name of diseases expressing the cerebellar ataxia as a main symptom. There areover 30,000 SCD patients in Japan, and 10,000 are hereditary. Comparing to Europe or America,
the proportion of autosomal dominant SCD patients is high.
Autosomal dominant SCD is called Spinocerebellar Ataxia (SCA), and same as otherneurodegenerative disorders, SCAs are progressive and the genetic anticipation, increasing severity
and decreasing age of onset with successive generations of pedigree, is observed in some of SCAs.
Cerebellar, brain stem and spinal cord slowly degrade in SCA patients. By the genomic analysis,
SCAs are classified and named from type 1 (SCA1) and in 2013 the new type of SCA was reported(SCA37).
But the numbering of SCAs is not complete: It is said that some are vacant, and some of theircausative genes are overlapped on genome and the more detailed researches are needed. Not only
the incomplete naming, the molecular mechanisms of onset of SCAs are not also revealed.
Because there is no way to cure and these are late onset and progressive disease in highly aged
society, we have many problems with SCAs. But there are some reports suggesting that therehabilitation is effective to delay the progress of ataxia.
To make the information clear and study the effects of the rehabilitation, I set two themes intraining program of Leaders for Integrated Medical System (LIMS program).

111

Themes of research in LIMS program
1) Molecular pathological study of spinocerebellar ataxia.
2) Nursing care and rehabilitation for patients with spinocerebellar ataxia.
Previous study (in my first year of master course)
At first, I studied about foundation of SCAs in Japan. The sum of patients with SCDs is about
30,000. A third of total SCDs patients (10,000 people) are hereditary. In hereditary SCD, firstly
SCA3 patients are the most, the second is SCA6, SCA31, DRPLA, SCA1, SCA2 and other SCAs (7,8, 17, 36). But the cause of residual hereditary SCDs (one third) remains unknown. Second, with Dr.
Yamashita’s cooperation, I could get an appointment to see two patients, one suffers SCA6 anothersuffers SCA36. There are many reports which suggest the effect of rehabilitation. And two patients(including father and aunt of SCA6 patient) showed the possibility that rehabilitation is effective to
the SCAs. Some of SCAs show slow progress and the death of neurons may be also slow. If neurons
die because the neuronal activity become low, we can help the dying neurons by making neuronal
activity high. The rehabilitation or the drugs may be helpful for activation of neurons.
Results and Discussion (in my second year of master course)
I summarized the information of SCD causative genes, main phenotypes, distributions and the ageof onset of SCAs from ORPHANET database. (Table 1)
Many types of diseases are reported, from 1 to 37. But SCA9, 24 and 33 were regarded as vacant.
Some reports said SCA 15 and 16, SCA5 and 24 and SCA19 and 22 were respectively same diseasebecause the loci of these causative mutation on the genome are overlapped. Actually, 32 SCAs arefounded now.
But I found some interesting points when I was summarizing the reports. The causative genes of
SCA23, 35 and 36 are not same but on the same loci 20p13. Similar thing was observed in SCA6
and 26, SCA13 and 14 and SCA15/16 and 29, they are on 19p13, 19q13 and 3p26.1 respectively.
(SCA15/16 and 29 are caused by the mutation in the same gene.) Because the kinds of mutation are
different, the mechanisms of onset may be different and the treatments for these diseases have to be
distinguishable. (But there is a possibility that these mechanisms of onset are same, particularly
SCA15/16 and 29.) However, the number of these patients is very small and therefore it is difficult
to confirm the kinds of mutation. Of course there are many problems, but I think, only for thedetection of the SCD type, we have to use next-generation sequencer. By reading the sequences ofpatient genomes, we can classify more precisely.

112

113

19p13

3p21.1-p12

13q21

SCA6

SCA7

SCA8

15q15.2

5q31-5q32

19q13.3-q13.4

19q13.4

3p26.1

SCA11

SCA12

SCA13

SCA14

SCA15/16

SCA16

22q13

SCA10

SCA9

11q13.2

SCA5

ITPR2

ITPR1

PKCG

KCNC3

PPP2R2B

TTBK2ATXN10ATXN8/ATXN8OS

ATXN7CACNA1ASPTBN2

PLEKHG4

16q22.1

ATXN2

SCA4

12q23-q24.1

SCA2

ATXN1

ATXN3

6p23

SCA1

Gene

SCA3(MJD) 14q21

mutation locus on the genome

SCA type

Table 1. Summary of SCDs

Inositol triphosphate receptor type-2

Inositol triphosphate receptor type-1

Protein kinase C ganma

Potassium channel

Serin/Threonine protein phosphatase 2A

Tau tubulin kinase 2

Ataxin-10

Ataxin-8

Ataxin-7

intron 9

symptom
proprioceptive loss, hypoactive reflexes, ophthalmoparesis, and mild optic
neuropathy

cerebellar ataxia, pyramidal signs, and peripheral sensory loss
cerebellar signs (ataxia, dysarthria, and intention tremor) with eye movement
abnormalities such as gaze-evoked nystagmus, down beat nystagmus, andimpaired smooth pursuit

frame shiftdeletion

missense

missense

missense

cerebellar signs, hyperreflexia and decreased vibration sense

SCA13 is primarily a cerebellar syndrome, but dysphagia, urinary urgency, andbradykinesia have been described in affected patients older than 50.

CAG repeats at the 5' end of It is characterized by the presence of action tremor associated with relatively mild
the PPP2R2B gene
cerebellar ataxia.

cerebellar syndrome and epilepsy, sometimes mild pyramidal signs, peripheral
neuropathy and neuropsychological disturbances
dysarthria and progressive ataxia, jerky pursuit, horizontal and vertical nystagmus
and ophthalmoplegia

muscle weakness, wasting, hypotonia, poor feeding, failure to thrive and loss of
motor milestones.

CTA/CTG repeats, CAG
repeatATTCT repeats

cerebellar ataxia and pigmentary macular dystrophy. muscle weakness, wasting,hypotonia, poor feeding, failure to thrive and loss of motor milestones.

CAG repeats, usually 36 or
more CAG repeats

CAG repeats, SCA6 patientsare usually of 21-29 CAG
cerebellar signs of ataxia and dysarthria as well as dysphagia
repeats

missense

unknown

CAG repeats, the normal
CAG repeat length is 15-24
very similar to SCA1 but some patients show Parkinsonism
and the SCA2 patients have
35 and longer repeats.
SCA3 is divided into 3 forms(MJD1, MJD2, MJD3). SCA3 type 1 (MJD Type 1,
see this term) is associated with ataxia, ophthalmoparesis, pyramidal signs such
CAG repeats, The normal
as spasticity and hyperreflexia, and extrapyramidal signs including dystonia andrepeat length is 13-41
other movement disorders presenting in adolescence. SCA3 type 2 (MJD Type 2,
whereas repeat lengths
see this term) presents in middle adulthood with ataxia, spasticity, and dystonia.
causing SCA3 are greater
SCA3 type 3 (MJD Type 3, see this term) occurs after the age of 40 and includes
than 56.
ophthalmoparesis and anterior horn cell disease, i.e. fasciculations, atrophy, andweakness. Parkinsonism can also be a feature of SCA3. A likely overlooked but
common feature is impairment of temperature sensation involving the entire body.

CAG repeats

Locus of mutation
Mutation(intron/exon)

alpha1A subunit of voltage-dependent calcium channel exon 47

Beta-III Spectrin

Puratrophin 1

Ataxin-3

Ataxin-2

Ataxin-1

protein114

7q22-q23

1p21-q21
11q12.2-11q12.3, overlapping with the locus
for SCA5

7p21.3-p15.1

20p12.3-p13

2p15-p21

19p13.3

13q34

18p11.21

3p26.1

4q34.3-q35.1

16q21

7q32-q33

SCA18

SCA19/22

SCA21

SCA22
SCA23
SCA24

SCA25

SCA26

SCA27

SCA28

SCA29

SCA30

SCA31

SCA32

6q14

20p13

20p13

1p32 and named the SCA37 locus

SCA34

SCA35

SCA36

SCA37

SCA33

SCA20

6q27

SCA17

TATA-box binding protein

unknown

NOP56

TGM6

ELOVL4has not yet been
identified

BEAN

not identified

ITPR1

AFG3L2

FGF14

eEF2

KCNC3

KCND3
PDYN

unknown-

Nucleolar protein 56

Transglutaminase 6

Elongation of very long chain fatty acids protein 4

Brain expressed protein associated with NEDD-4-

Inositol triphosphate receptor type-1

ATPase family gene 3 like protein 2

Fibroblast growth factor 14

Eukaryotic translation elomgation factor 2

Kv3.3 voltage-gated potassium channel

Kv4.3 voltage-gated potassium channel
Prodynorphin-

no responsible genedetected
KCND3
Kv4.3 voltage-gated potassium channel

TBP

GGCCTG repeats

missense

TGGAA repeats

missense

missense/frame shift

missense

in frame deletion
missense

duplication

missense

CAG repeats

progressive gait and limb ataxia, dysarthria, ocular dysmetria, intention tremor,
pseudobulbar palsy, spasmodic torticollis, extensor plantar responses (Babinskisign), reduced proprioception, and hyperreflexia
ataxic dysarthria, truncal ataxia, limb ataxia, general hyperreflexia and variably
occurring lower limb spasticity
slowly progressive cerebellar ataxia (starting with falls, dysarthria and clumsinessfollowed by other cerebellar signs) along with altered vertical eye movements.

Progressive ataxia, dysarthria, decreased reflexes, and nystagmus

Manifestations include cerebellar ataxia, cognitive impairment and, in males,
azoospermia. Cerebellar atrophy

Ataxia, dysarthria, and horizontal gaze nystagmus

oculomotor dysfunction, moderate dysarthria and ataxia that progresses slowly
and eventually leads to mobility impairment

Mild developmental delay, learning difficulties, and language dysfunction are
frequently reported.

juvenile onset, slowly progressive cerebellar ataxia

The clinical features vary widely from sensory neuropathy with little cerebellar
ataxia to cerebellar ataxia with little sensory neuropathy.
Slowly progressive gait ataxia, dysarthria, nystagmus, impaired pursuit, anddysmetric saccades were reported in all patients.
early-onset tremor, dyskinesia, and slowly progressive cerebellar ataxia.

axonal sensory neuropathy, while cerebellar ataxia and motor neuron dysfunction
develop later

It is characterized by a variable clinical picture which can include dementia,
psychiatric disorders, parkinsonism, dystonia, chorea, spasticity, and epilepsy.

SCA type
SCA1

Prevalence and Distribution
Age of onset
SCA1 affects 1 to 2 per 100,000 people worldwide.
onset ranges from 4 to 74 years.
SCA2 is very common in Cuba, particularly in the Holguín
Average is 30 years but can range from 2-65
SCA2province, where approximately 40 per 100,000 individuals are
years.
affected.
The highest prevalence has been found in the Azores (Flores
Island (1/239)), intermediate prevalence rates in Portugal,
SCA3(MJD)
Germany, the Netherlands, China and Japan, and lower
prevalence in North America, Australia and India.
The causative gene was detected in kindreds from Utah (USA)
SCA4
and Germany.
Only three families (American, French and German) with SCA5
Average is 33 years but can range from 10-68
SCA5
have been reported to date.
years.
It is most commonly seen in Japan, Korea, the Netherlands andAverage is 45 years but can range from 16-72
SCA6
Germany. In Japan, there are about 3,000 SCA6 patients.
years.
The estimated worldwide prevalence of SCA7 is less than
1/100,000 and it is thought to account for 2-4% of all forms of SCA
SCA7(up to 7% in Asian populations). Higher prevalence is described insome populations such as in Scandinavia or South Africa.
SCA8
SCA9
Many kindreds have been found in Mexican and Brazilian
Average is 32.2 years but can range from 18SCA10
populations. SCA10 is the second most common inherited ataxia
45 years.
in these two countries.
Fifty-one clinically affected members from four families (of British,
Average is 25 years but can range from 11-70
SCA11Pakistani, German and French descent) have been reported toyears.
date.
SCA12
Approximately 40 families have been reported.
onset ranges from 8 to 55 years.
SCA13
Fewer than 20 cases have been reported to date.
The disease has been reported in more than twenty families from Average is 33.9 years but can range from 10SCA14
Europe, the United States, and Australia.
70 years.
Fewer than 80 patients affected by the disease have been
Average is 39.6 years but can range from 20SCA15/16
identified to date.
66 years.
SCA16
ocal prevalence is 0.47 per 1,000,000 in the Japanese population
SCA17
and 0.16 per 100,000 in North-East England. Fewer than 100
families have been reported to date.
Only 26 cases in a 5-generation American family of Irish ancestry
SCA18
onset ranges from 13 to 27 years.
have been reported to date.
Only 12 cases in a 5-generation Dutch family have been reported
SCA19/22
onset ranges from 10 to 46 years.
to date.
Fewer than 20 cases in a 4-generation Australian family of Anglo- Average is 46.5 years but can range from 19SCA20
Celtic descent have been reported to date.
64 years.
Fewer than 20 cases in a 4-generation French family have been
The mean age of symptom onset was 17.4
SCA21
reported to date.
years.
SCA22
SCA23This subtype has only been described in 4 Dutch families.
onset ranges from 43 to 56 years.
SCA24
Fewer than 10 cases in a 4-generation French family have been
SCA25
onset ranges from 1 to 39 years.
reported to date.
To date, only 23 affected patients have been described from one Average is 42 years but can range from 26-60
SCA26
American family of Norwegian descentyears.
SCA27
Fewer than 30 cases have been reported to date.
Prevalence is unknown. SCA28 accounts for approximately 1.5% The mean age of symptom onset was 19.5
SCA28
of all European cases of ADCA.
years.
The prevalence is unknown. More than 50 cases have been
SCA29
reported in the literature.
SCA30 has only been described in 6 patients from one Australian Average is 52 years but can range from 45-76
SCA30
family to date.
years.
SCA31 is the third most common form of ADCA (see this term) inJapan, where more than 20 families have been reported to date. It Average is 58 years but can range from 8-83
SCA31
is rarely found in other Asian countries and is extremely rare inyears.
Western countries.
SCA32
SCA32 has been reported in one Chinese family to date.
SCA33
Disease onset occurs shortly after birth withthe appearance of papulosquamous,
SCA34 has been reported in 25 members of one FrenchSCA34
ichthyosiform plaques on the limbs, which are
Canadian family to date.
often only present in the winter. After the ageof 25 they tend to disappear completely.
SCA35 has been reported in less than 20 cases from 3 Chinese
SCA35
onset ranges from 40 to 48 years.
families to date.
The prevalence is unknown. SCA36 has been described in at
SCA36
least 14 Japanese and Spanish families in approximately 90
individuals.
SCA37 has been reported in nine members of a Spanish kindred
SCA37
to date.

115

Future plan
1. Continue studing the effect of rehabilitation and suggest the easy exsercise effective for SCD.
2. Elucidate the mRNA splicing mechanisms of CACNA1A gene, causative gene of SCA6.
Cooperation
1. Yasuo Mori, Graduate school of Engineering, Kyoto University.
2. Ryosuke Takahashi, Graduate School of Medicine, Kyoto University
3. Hirofumi Yamashita, Graduate School of Medicine, Kyoto University
4. Naoko Inaba, Center for the Promotion of Interdisciplinary Education andResearch, Kyoto
University
5. Christian Altmann, Graduate School of Medicine, Kyoto University
Reference
1.

Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions
in the alpha 1A-voltage-dependent calcium channel. Olga Zhuchenko et al. Nature genetics(1997)

2.

Primary structure and functional expression from complementary DNA of a brain calcium
channel. Yasuo Mori et al. Nature (1991).

3.

Zenjiro Matsuyama et al. Human Molecular Genetics (1997).

4.

Olaf Riess et al. Human Molecular Genetics (1997).

5.

K Ishikawa et al. Am. J. Hum. Genet. (1997).

6.

I Yabe et al. Journal of Neurological Science (1998).

7.

Y Nagai et al. Journal of Neurological Science (1998).

8.

Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type ofspinocerebellar ataxia accompanied by motor neuron involvement. H Kobayashi et al. The
American Journal of Human Genetics (2011)9.

Classification of ataxia (from National Ataxia Foundation)

10. http://www.nanbyou.or.jp/entry/284 Japan Intractable Diseases Information Center
11. http://www.orpha.net/consor/cgi-bin/index.php?lng=EN Orphanet database
12. T Tunemi et al. Neuroscience Letters (2008)116

Conference Reports
Report attending 6th Bordeaux RNA Club Workshop
Report attending
6th Bordeaux
Maki
Sakuma RNA(M2) Club Workshop
Maki Sakuma (M2)
Place: Bordeaux, France.
Date: 26th and 27th of June, 2014.
Meeting description:
6th Bordeaux RNA Club Workshop is an annual event that gathers researchers all over
the world to present their progress on their research on RNA. Especially Bordeaux
University has excellent facilities and research groups in RNA structural biology andinvited some of the most prestigious RNA researchers, including the Nobel laureate
Thomas Steitz, in order to promote open discussion of the most recent research resultsof the participants. The workshop consisted of five 50-minute presentations by theinvited speakers, eleven 20-minute presentations by selected participants, and two
sponsor presentations, with three breaks and poster session.
My presentation:
My presentation was on the effect of compound TG003 on splicing and its therapeutic
application. Since the LIMS objectives are to contribute to the problems of super aged
society through research, two broader objectives of my presentation were to (1) promote
the idea that small chemical compounds have potential in treating diseases arising frommutated genome targeting RNA, especially targeting pre-mRNA splicing, and to (2)show that the global transcriptome-wide approach (RNA-seq analysis) can identify
features of sequences that respond to chemical treatment. Although the presentation
centered on the disease Duchenne muscular disease, the message that our research pays
the effort to bridge basic research and translational medicine and its possible application
to other diseases was clearly stated. My presentation was related to my LIMS researchin that I presented results that used the techniques to analyze the response of cells tochemical treatment and I plan to identify and show that the compound of interest is safeand effective looking at the transcriptome.
Response: My presentation, especially the aspect of the application to therapy, was wellreceived and appreciated. The questions were mainly on the discovery process of thecompound TG003 and its effect to splicing in other experimental setup and mousemodels. The fact that TG003, as being an inhibitor of just one family of the kinases of
the SR proteins, can alter the splicing was a surprise to some, and its possibility of
becoming an RNA drug seemed to be inspiring.
117

Other presentations and useful information for future research:
Two out of five of the invited speakers (Ann-Bin Shyu and Raùl Méndez) mentioned on
the importance of intrinsically disordered regions in the RNA binding proteins.
Intrinsically disordered proteins have many interacting partners for their binding
flexibility and are major upstream regulators of many cellular processes. For example,
there is alpha-synuclein, which is involved in many neurodegenerative diseases.
Possibly looking at the intrinsically disordered protein region in RNA binding proteins
can lead to a discovery of RNA binding protein that is related to neurodegenerative
diseases or other important diseases that is especially problematic to our super aged
society.
Nick Proudfoot talked about G-quadruplex structure and its relevance in DNA
damage and cancer. This structure was not familiar to me before, but this has attracted
attention as a novel target anti-cancer therapy. So this is another keyword that I would
like to explore in order to think of directions of future research for tackling the problem
of super aged society.
Rheinhard Lührmann mentioned that he is developing small chemical compounds
that target the spliceosome. His main objective was to study the transition stages of the
spliceosome, but possibly some of the compounds he discovered may have anti-tumor
activity, so his research findings will be very interesting to follow.
Useful information for program coordinators:
After I gave the presentation a few researchers came to talk to me about mypresentations and in the course I mentioned that I have the three-months period of
foreign internship. I asked for opportunities for aging research in Europe and most ofthem mentioned that they heard of a research institute in Cologne Germany, and I thinkthat they were talking about the Max Planck Institute for Biology of Ageing. So it seems
the Max Planck Institute for Biology of Ageing is gaining recognition as arepresentative in the research field, so perhaps LIMS and the institute can have somekind of communication.
In the RNA field, most research that is related to ageing is cancer, and thestructural aspect of DNA and RNA has more influence to the pathology that I expected,
and so courses on structural studies of biological molecules would benefit the students
understanding and possible inspiration in inventing new technologies.

118

Conference Report of SPIE Photonics West 2015
Conference Report of SPIE Photonics West 2015
Mikako Gomyo (M2)(San Francisco, U.S., 7th to 10th of February, 2015)
Mikako Gomyo (M2)(San Francisco, U.S., 7th to 10th of February, 2015)
1. Brief overview of the conference
I could have the opportunity to attend the international optics conference, “SPIE
Photonics West”, held in U.S. It is said to be the largest conference involved in optics
including photoacoustics; there were 4,728 presentations and over 1,250 companies lastyear. I was really impressed with many latest and innovative reports, and there wereenormous contents for providing me with my LIMS research ideas, “Quantitative
assessment of photoacoustic properties of biological tissues by photoacoustic
microscopy”.

2. Presentations of the latest studies
I have learned particularly about the photoacoustic technology at the sessions of“Multimodal Biomedical Imaging” and “Optical Elastography and Tissue Biomechanics”
among many courses I visited. Some impressive studies are introduced below.
The measured objects by photoacoustic technology appear to be expanding theseyears, and I got interested in the applied technique for dermis as a clinical subject. The
section of “Multimodal Biomedical Imaging” contained the combined technology of
optics and acoustics, called photoacoustics. Many kinds of photoacoustic applications
were demonstrated on dermis, cerebral status, and so on. I consider the field of
dermatology as especially in demand because no device which can express
quantitatively distribution of substances beneath skin has ever been invented. My
research should be involved in dermis or related diseases responding to the expectation
for this field.
The fusion technology of optics and ultrasound elastography emerged in theimmediate past and was given in “Multimodal Biomedical Imaging”, and it is underinvestigation from many viewpoints. “Noninvasive 3D elasticity mapping using
phase-stabilized optical coherence elastography” showed the feasibility of application forcornea, which really surprised me; although I research ultrasound elastography in order toelucidate stiffness of human soft tissue, I have never come up with the concept ofmeasuring stiffness of eye. Further realistic perspectives of the fusion technique stated in119

“Amplitude-modulated ultrasound radiation force combined with phase-sensitive opticalcoherence tomography (OCT) for shear wave elastography (SWE)”. While both OCT and
SWE have already yielded practical applications, the proposed pulse compression by
amplitude modulation suggested that in the fusion field of optics and acoustics the
proposed method could satisfy the safety criteria of eye imaging (e.g. Mechanical Index <0.23).
At present any photoacoustic methods have not been in clinical use, however, I am
sure that the investigation of photoacoustics for further applications progresses
gradually and steadily as my finding from the conference.
3. Experiences
I could have a talk with the prominent professor, J. C. Bamber, I met before in aninternational ultrasound conference, and I got to know he was involved in the fusion
technique of optics and ultrasound. Since in this conference most people specialize
optics basically, I felt a great potential in the fusion technique, photoacoustics, judging
from talks by the professional of ultrasound.
I attended optional whole-day workshops of academic skills in the last day of myattendance. Various workshops are held by SPIE every year, and participants of thecourse I attended were age 24-52 bracket. The lecturer who published several books
about academic presentation and writing provided interactive discussions for us. I could
learn the essence of presentation and writing with incepting other members, especially
postdoctoral researcher of OCT from Ireland whom I keep in touch even today. In
addition, I could make fellows who lead to SPIE student club, and we promised eachother that Kyoto University would join the student club next time. I could obtain theopportunity to improve my academic skills and to be acquainted with researchers
involved in this field.
4. Conclusion
All things I experienced in this conference highly motivated me for research andstudy in LIMS program. I have a keen desire to go back to the conference again withmy publication related to photoacoustics. The opportunity to attend the conference
provided me with much more perspectives than I had expected.

120

Congress Report

Congress Report
Atsuko Ishida (M2)0730257793 Atsuko Ishida[Outline]
Congress Name: 16th International Congress of the World Federation of Occupational
Therapists in collaboration with the 48th Japanese Occupational Therapy Congress andExpo
Dates of Exhibition: June 18-21, 2014
Place: Pacifico Yokohama, Yokohama, Japan
Theme: Sharing Traditions, Creating Futures[About Our Research]
We presented a research about falling risk of patients who were right brain damaged(RBD) due to stroke. In previous study, researchers reported that patients with RBD fell
more than left brain damaged patients and they considered this was by left hemiplegia
or unilateral spatial neglect (USN). However, the assessment on hemiplegia or USN
cannot find falling risk, especially patients with mild disorder.
In this research, we investigated the relationships between falling risk of RBD
patients and other assessments related frontal lobe.
In the result, falling risk of RBD patients had correlation with Mini Mental State
Examination (MMSE), Line Bisection test, situation judge test, and Awareness test.
And according to each result of those assessments, patients who showed good result inassessments of hemiplegia or USN got low score on situation judge test or awarenessand they had moderate falling risk. This suggested that falling risk related not only
hemiplegia and USN but also ability of situation judge and awareness.
Some occupational therapists (OT) in hospital asked us about this research. Many
questions were about new assessment which added in this research and they told thatthey tried to assess frontal lobe ability by using this assessment. Other OT pointed outthat we didn’t control duration of feeding period after stroke, and further explanation
was required about the different case with conclusion. We planned to conduct further
research based on those advises.
[Findings]
 This congress was world federation for OT and there were many clinical research
about actual daily care. All sessions included techniques and methods of each country
and I could compare Japan and other countries.
For example, in Ireland, inmates in nursing home work as café staff there. This is oneof assessments on social skills. OT can evaluate inmates’ social function in nursing
home. Or in Malaysia, nursing home has ‘shelter room’ for inmates who had falling risk,
and in the room, staff pay attention with falling. These introduction gave me new view
about the place OT working. I thought these large scale program should be added and121

For example, in Ireland, inmates in nursing home work as café staff there. This is oneof assessments on social skills. OT can evaluate inmates’ social function in nursing
home. Or in Malaysia, nursing home has ‘shelter room’ for inmates who had falling risk,
and in the room, staff pay attention with falling. These introduction gave me new view
about the place OT working. I thought these large scale program should be added andbe carried out in Japan, too.
 There were some researches on falls in elderly effected by aging society. One research
revealed where falling accidents happened or who had falling risk and other groupresearched effects of fall times by intervention like physical exercises and mental
supports. As far as I could see, there were no presentation on ‘risk of domestic accident’
which we work on. However, I considered that we can use the idea of falling risk to our
research by changing the index of risk.

Conference Report

Kouki Shinoda (M1)

           



              

        




          

          

                     
122




          

          

                     



          
          
           
        



 
Dr.
Moriya gave a presentation on the factors which determine the expression limitof all protein-coding genes of budding yeast. They developed a genetic method called
genetic tug-of-war (gTOW) to measure the copy number limit of overexpression of atarget gene. Yeast cells are transformed by the plasmid encoding a target gene with
its native regulatory sequences, and the gene becomes proportionally overexpressed
according to the increased copy number. By using this method, his group showedthat yeast cellular system was robust against an increase in the copy number by up
to 100 copies in over 80% of the genes. They also showed that the limitations of copy
numbers were affected by some factors such as the load of turnover and imbalance ofcomponents of constituting protein complex. Circadian rhythm is generated bynegative feedback loop of clock genes. To understand the limit and threshold ofexpression levels of clock genes might enable us to control circadian rhythm byachieving the maximum expression of genes transiently.

Conference report
Hiroki Enno (M1)
The 36th Annual Meeting of the Japanese Society for Biomaterials(2014/11/17~2014/11/18, Tower Hall Funabori)This conference gives variety of lectures about biomaterials from the viewsof basic material, basic technology, basic clinic and basic industry.

123Impressive lectures
1A-SL1 細胞シート再生医療の創生

岡野光夫

The speaker gave us a lecture about the preparation of cell sheets for regenerative
medicine. I was impressed because this technology was derived from a simple polymer
which shrinks depending on the temperature, and he applied that to the removal of thecells from cell dishes. It would have been difficult for me to come up with such innovative
idea, using polymers for this kind of biological application.
2A-S2-1 機能性ポリマーや化合物によるヒト多能性肝細胞の増殖分化制御への応用
中辻憲夫
The lecture was about the practical procedure to produce iPS cells in bulk. The
technology seemed simple but very powerful. This lecture made me realize how
important it is to apply such technologies to biological fields.
1F-14 ナノ流体スマート制御へ向けたチオール化温度応答性ポリマーの分子設計と合成、
評価

四宮未郷

The speaker talked about the application of thiol polymer, which can be controlled bytemperature, for micro fluid devices. From this lecture, I understood the importance of
micro fluid devices for the medical field and the demand of such kind of materials that
control small amount of substances. I believe that my current research filed, porous
coordination polymers, has the potential to play important rolls in the fields of micro
fluid devices in the future because they can also control small molecules.
2E-21 腫瘍でくすりを作る“酵素封入型 PICsome”の機能評価

安楽泰孝

The lecture gave me the new insights about drug delivery system (DDS). Compared tothe conventional DDS, his approach was unique because instead of drugs, enzymes thatcan generate drugs at specific sites of tissues were delivered. Using this system, we candeliver stable precursors of drugs or some kind of generator of drugs such as proteinsinstead of unstable drugs.

Useful information for my research
1. In the past few decades, micro fluid devices have become one of the most important
technologies in the medical fields because they enable us to make diagnosis instantlywith just a drop of blood. However, handling small amounts of substances at nanolevels is still a problem. Porous coordination polymers (PCPs), on which I base myresearch, can easily handle small amounts of molecules, even if they are gas
molecules. So PCP should be an excellent candidate for this field.
2. There are three factors controlling cell function, namely biochemistry, physicalchemistry and structural mechanics. In this conference, there were many reports
showing that some stimuli also controlled cell growth. From this point of views, I canalso control the cell by stimulating some chemical compounds from PCPs.

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3. As a biomaterial, there are many different ways to apply iPS cells in the medical field,
such as cell sheets. So, when we consider how it can be applied in this field, it isbetter to focus not only on clinical medicine but also on regenerative medicine. Thisis because there is much room to be developed for the field of regenerative medicine,and it will have a high impact for society.

Useful information for other LIMS members
2D-07 細胞の形を操る形状記憶培養皿の開発

荏原充宏 (for Aila, Shinoda and Dojo)

The speaker talked about the cell culture dishes, whose surface structure can change bytemperature. So by using these cell dishes, the morphology of cells can be controlled. It
may be important for nerve cells (for Aila) to control the preferable direction of cell
growth. Additionally, for the clock gene expression, the morphology change will affect its
function. I thought that this information would be interesting for cell research.
1E-08 配向制御型細胞シートを用いた異方性を有する筋組織の構造制御 (for Nishitani)
To realize complicated structure like our body tissue in cell dishes, the key is to control
the direction of cell growth. For example, skeletal muscles are grown as a bundle for one
direction. So the speaker tried to control the direction of cell growth by using cell dishes,
whose surface was covered with polymer and modified in a one-direction-pattern at microlevels. Nobuhiko Nishitani, a LIMS student, studies about the self-assembly of small
molecules and the surface of it. If he can regulate the surface of the cell dishes by using
self-assembly of small molecules, he may be able to control cell growth directions at themolecular level.

Report of attending 37th Annual Meeting of the molecular biology society of Japan
Kumiko Dojo (M1)
Place: Pacifico Yokohama
Date: 25th-27th of November, 2014
Meeting description
The annual meeting of the Molecular Biology Society of Japan is the largest molecularbiology meeting in Japan. Many researchers from various field gathered in this 37th
annual meeting and gave talks and put up posters of leading edge study.

125Impressive lecture
1W6-2 岩本和也
「脳ゲノム解析と精神疾患」
Schizophrenia is a serious mental disease, and its socioeconomical loss is huge.
According to the results of the human genome project, it turned out that half of thehuman genome is composed of repeated sequence which seems meaningless. One thirdof the repeated sequences are called LINE-1. LINE-1 are retrotransposons, which
amplify themselves in a genome, and induce disorders of proper recognition of DNA
sequence. The presenter and his colleagues measured the amount of LINE-1 sequence inthe schizophrenia patients and found that the patients significantly have more LINE-1
sequence compared to the healthy subjects. They also found that development of these
diseases have both genetic and environmental backgrounds. The presentation was very
impressive because it reminded me of the LIMS course where I went to the care centerfor schizophrenia patients. I hope these findings will compensate for the development of
diagnosis, prophylaxis, and cure of schizophrenia.
Useful information for my research
1P-0706 Jun Nakano“Regulation of mouse affective behaviors by the circadian clock in the forebrain.”In the era of relentless work, our body clock is perturbed. Due to rotating shift-workand work at midnight, phase relationships between internal circadian rhythms and theexternal day/night cycle are unfitted. Continuing these types of lifestyle can end up withserious mood disorders including major depressive disorder and bipolar disorder. The
presenter and his colleagues showed that mouse anxiety-/ depression-like behavior issignificantly perturbed in mice which lack circadian rhythmicity of clock genes in theforebrain. This finding astonished me because regional impairment of clock genes inbrain affected the whole-body. Age-related loss of function in a specific part of the brain
may cause disorder of clock genes, leading to whole-body level of disorders.
2P-0487 Kiyomichi Imamura「高浸透圧刺激による時計リセットシグナリングおよび遺伝子応答の解析」
Almost all organisms have a circadian clock, which keeps the approximate 24 hourrhythm in our body. The clock is composed of clock genes including BMAL1 along with
their important post-translation regulations that maintain rhythmicity. The members in
his laboratory found c-Jun N-terminal kinase (JNK) as a novel clock gene kinase. The
presenter and his colleagues found that the phase of clock is re-set by activated JNK
through hyperosmolar stimulation. They next profiled genes which responded to thestimulation, and found Dec1, Dec2, and E4bp4 were specifically transcribed as targets.

126

They suggested this novel finding would be important for development of a novel field of
diseases related to jet-lag, sleep disorder, and lifestyle diseases which result from shiftworking. This presentation gave me important information for my own LIMS theme tothink and find a solution for patients with shift-work diseases.
Useful information for other LIMS members
1P-0766 Mayumi Takahashi「clk-1 トランスジェニックマウスにおける寿命延長とミトコンドリア機能低下」
The clk-1 gene encodes an enzyme necessary for bisynthesis of coenzyme Q (CoQ). It
is already reported that loss of function of clk-1 in C. elegans elongates life expectancy.
The research was not applied to mammals because they cannot survive without the gene.
So the presenter and her colleagues rescued the clk-1 knock-out by dose-dependent clk1 transgene. This mouse express less CoQ. As a result, the life expectancy of both maleand female transgenic mice elongated. They insisted that less CoQ in the clk-1 transgenic
mice caused decreased function of mitochondrial metabolism in the muscle, which caused
whole-body level of decreased metabolism and miniaturization, leading to concomitantelongation of life expectancy. This discovery suggests that clk-1 is a novel mammalian
longevity factor.

Conference report
Masatoshi Uno (M1)
The 37th Annual Meeting of the Molecular Biology Society of Japan(2014/11/25~27 / at Pacifico Yokohama in Japan)
1. Summary of Meeting
This Meeting is an annual event of Molecular Biology Society of Japan, it is anacademic conference of general molecular biological research. Main topics of thisconference treated not only molecular biology that included cell biology, structural
biology, genetics etc., but also educational activities for research fraud and career
support for young researchers.

2. Useful presentation for my research in the conference(1) RDF を用いたパスウェイ・マップの統合[2P-0969]

127

The presenter of this poster said, in nowadays research data of biological signal
pathway map were uploaded with various formats in many sites. This situation was notuseful and opposed discovery. So he proposed that all signal data file would convert asingle format and integrate their data. In summary, he would standardize and integrate
biological pathway map data. This proposal was so useful because I had proposed asimilar theme of LIMS research in this semester.
(2) リウマチ様関節炎発症における F759 マウスと野生型マウスの違いのコンピュータモデ
ルによる解析[3P-0705]
The presenter of this poster researched Jak-STAT signaling system of IL-6R
downstream, and this signaling system was forecasted to concern Rheumatoid arthritis.
He simulated and compared natural system and system of mutant induced Rheumatoid
arthritis. This proposal would be helpful my LIMS research because I will research
signal system of Rheumatoid arthritis in LIMS research.

3. Useful information for other LIMS students in the conference(1) Let’s think about career paths for young life scientists [1F7]This forum introduced some career support activity for students in doctoral programand postdoctoral at some Universities and some talking by office workers. Especially,
career support program of Nagoya University had more achievements of internship. It
will be helpful for internship program of LIMS. For details, please refer to the following
web site.
{http://www.aip.nagoya-u.ac.jp/index.html }

128

5.
広 報
Public Relations

6.
産公学連携
Industry-Public-Academia
Cooperation

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139

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141


ホームページ改定への取り組み(LIMS)
文責： 山本浩司（LIMS特定准教授）

本年度は LIMS ウェブサイトに対する要望への対応、およびより効果的且つ魅力的な情報発信を目指してデザ
イン変更やコンテンツの整理・拡充に取り組んだ。

▪

アクセス解析からわかる傾向
サイト改変を進めるに際し、各ページへのこれまでのアクセス回数を分析して以下の傾向が認められた。
••

日本語ページで最もアクセス数が多かったのは「指導スタッフ」のページである••

次いで日本語ページでは「募集概要」、プログラムの「概要と目的」と続く••

英語ページで最もアクセスが多かったのは「募集概要」のページである••

次いで英語ページでは「プログラムの内容」、「カリキュラムの概要」と続く（ただし、学内限定ページに関する情報は除く）()

日本語ページで「指導スタッフ」のページにアクセスが集中していたのは意外であった。LIMS
LIMS プログラムのイメージを掴むうえで、参画分野や教官が重要な情報源になっているようである。一方、英語ページへのアクセスでは
概要的要素が重視される傾向にあったが、それ以外のコンテンツへのアクセス数は低かった。従って、各コンテンツの概要を充実させること、あるいは概要と他ページのコンテキストを明確にすることが重要であると考えられた。

▪

優先的に改変を試みている項目
上記傾向と直接寄せられた意見を元に、以下の３点に注力してウェブサイトの改変に取り組んだ。
1. トップページの構成を変更し、見易さやactivity
activity の伝わるデザインにする
2. コンテンツ間で重複した内容をまとめ、リンク構成をわかり易くする
3. 外内部から要望の強かった Q&A
Q&A を設置する
トップページの改変は企業と連携し最終的なデザインの調整を行っている段階である（Fig.1
トンプページ草(Fig. 1案）。また、その他の項目も最終的な文言の調整や編集を行っている（Fig.2
Q&A の一例）。来年度上旬には新た)(Fig. 2 Q&A)
なサイトに更新予定である。

Fig. 1 トップページの草案

142

Fig.
Q&A の一例
Fig. 22 Q&A

Renewal of the LIMS website
Koji Yamamoto
Program-Specific Associate Professor, LIMS

In this year, we addressed redesign and improvement of the current LIMS website in order to put out more effective
and more attractive information on the Internet.
-

Historical trend analysis for the current website
The results found by analyzing the access frequency of each page in the current LIMS website were as follows:+ The most visited page in the Japanese sites was the "Staff" page.
+ The next popular page was the "Application Overview", and then the "Outline and Objectives" of the overview
on this program.
+ The most visited page in the English sites was the "Application Overview" page.
+ The next popular page was the "Program contents" of the overview, and then the "Curriculum overview".
(Exception of counting the number on the page limited to the domestic students (campus only))
The fact that the most frequent page in the Japanese sites was the "Staff page" was unexpected for us. Informationon the LIMS supervisors and their expertise appeared to be significantly important to grasp an image concerning LIMS
program. The traffic analysis for the current English pages had a trend focusing on the abstract of each category.
Considering these tendencies, it was thought to be important to enhance the abstract of each content and their contexts
in a new website.
-

Preferentially-improved contents
On the basis of those results and the requests from visitors, we preferentially focused on the following three points.
1. To redesign the front page so that our activities come through.
2. To minimize the inclusion of duplicate information and comprehensively display relation among each content.
3. To locate a Q&A site requested from both domestic and foreign visitors.
As to redesign of the front page, we are now working in collaboration with a design company and in the final stage(Fig. 1 Draft version of the LIMS front page). In addition, final adjustments and revisions of the terms in the otheritems are being processed (Fig. 2 an example of Q&A site). We plan to launch a new LIMS website in the early of thenext academic year.

Fig. 1 Draft version of the new front page.

Fig. 2 Example of Q&A site.

143⏘බᏛ㐃ᦠ
LIMS ࣉࣟࢢ࣒࡛ࣛࡣࠊ௻⏬ẁ㝵࠿ࡽከศ㔝ࡢ௻ᴗࡸබⓗ⤌⧊࡟⪺ࡁྲྀࡾㄪᰝࢆ⾜࠸ࠊࣉࣟࢢ
࣒ࣛᐇ᪋࡟㝿ࡋࠊࡑࡢ࠺ࡕ 20 వ⤌⧊ࡀ༠ຊ⤌⧊࡜ࡋ࡚ཧຍࡋ࡚࠸ࡿࠋ༠ຊ⤌⧊ࡢㅮᖌ࡟ࡼࡾࠊᗙ
Ꮫ࣭㆟ㄽ࣭ㄢ㢟ゎỴ࣭௻ᴗゼၥ࡞࡝ࡢᙧ࡛ㅮ⩏ࢆᐇ᪋ࡋ࡚࠸ࡿࠋㅮ⩏㸸
I. ་⒪ᕤᏛ≉ูㅮ⩏Ϩ㸸 㸶௻ᴗ㸶ྡ㸦1㸴ࢥ࣐㸧ㅮ⩏㢟ྡ㸸
1. ᶆ‽໬άື
2. ▱ⓗ㈈⏘ᡓ␎࡜ᅜ㝿ᶆ‽໬
3. ⏕యィ ࣭࢖࣓࣮ࢪࣥࢢᶵჾࡢ◊✲㛤Ⓨ
4. ་⒪ᶵჾ㛵㐃ᮦᩱࡢ◊✲㛤Ⓨ
5. ᅾᏯ་⒪࣭೺ᗣ⏘ᴗࡢ◊✲㛤Ⓨ
6. ගᢏ⾡ࡢ◊✲㛤Ⓨ࡜་⏝ᛂ⏝
7. ᩚᙧእ⛉ศ㔝࡟࠾ࡅࡿ᪂つ〇ရࡢ◊✲㛤Ⓨ࡟ࡘ࠸࡚
8. ἞⒪ᶵჾࡢᇶ♏◊✲㛤Ⓨ
II. ་⒪ᕤᏛ≉ูㅮ⩏ϩ㸸  㸵௻ᴗ㸶ྡ㸦14 ࢥ࣐㸧
1. ⥲ྜ་⒪ୖ࢜ࣇࡢຠ⋡ⓗ࡞ྍど໬
2. ኱つᶍ⬻᝟ሗࢡࣛ࢘ࢻࢆά⏝ࡋࡓ೺ᗣ㛗ᑑ♫఍ࡢᇶ┙ᵓ⠏
3. ⮬ື㌴㐠㌿ࡢᏳ඲ᛶ࡜ேⓗ⥴ᅉᏊ
4. ࣇ࢕࣮ࣝࢻᐇドࡢㄢ㢟
5. ࣊ࣝࢫࢣ࢔ࣅࢪࢿࢫ࡟࠾ࡅࡿᢏ⾡㛤Ⓨ࡜࣐࣮ࢣࢸ࢕ࣥࢢᡓ␎
6. ་⒪࣭೺ᗣ࡟㛵ࡍࡿࣅࢵࢢࢹ࣮ࢱࡢά⏝஦౛࡜♫఍ࢩࢫࢸ࣒ࡢ๰ฟ
7. ೺ᗣ࡞⏕άࢆಁࡍఫ⎔ቃ
III. ▱ⓗ㈈⏘㸤ᅜ㝿ᶆ‽໬㸸 ௻ᴗ࣭බⓗᶵ㛵 9 ⤌⧊ 9 ྡࠊ
㸦15 ࢥ࣐㸧
1. ་⒪⏘ᴗ࡟ᚲせ࡞ᢏ⾡㸤▱㈈⤒ႠᏛ
2. ᢏ⾡⤒Ⴀ࣭▱㈈⤒ႠᏛ࡜◊✲㛤Ⓨ
3. ๰⸆ࡢࣉࣟࢭࢫ㸯࣭᥈⣴ẁ㝵
4. ๰⸆ࡢࣉࣟࢭࢫ㸰࣭⮫ᗋẁ㝵
5. ๰⸆࡜་⒪⾜ᨻ㸦PMDA㸧
6. ་⒪ᶵჾ࡟࠾ࡅࡿᅜ㝿ᶆ‽໬
7. ་⒪ᶵჾࡢ㔜せ࡞ᅜ㝿つ᱁
8. ་⒪ᶵჾࡢ⸆஦つไ㸭ᅜ㝿㛤Ⓨ
9. ་ᕤ㐃ᦠࡢᐇ౛࡜ᒎᮃ
10. ་⒪᝟ሗ⏘ᴗࡢ๰ฟ
11. ࣋ࣥࢳ࣮ࣕ௻ᴗࡢࣅࢪࢿࢫࣔࢹࣝ࡜஦ᴗ㛤Ⓨ
12. ▱㈈ࡢᅜ㝿ࣁ࣮ࣔࢼ࢖ࢮ࣮ࢩࣙࣥ

Industry-Public-Academia Cooperation
We have been referring to opinions and comments of companies and local governments
since during planning LIMS Program. Twenty some of them are now supporting LIMS
program as Cooperators. In collaboration with lecturers from the cooperating organizations,144we prepared tree subjects in which students can receive interactive lecture, discussion,
problem solving practices on practical issues in the real world..
Subjects:
I. Medical Engineering for Society I:
Eight lecturers from 8 companies (16periods)
Theme of class:
1. Introduction to the Standardization
2. Strategies for Intellectual Property and Global Standardization
3. R&D for Biometric Imaging Analysis
4. R&D in Biomaterials and Bio-devices
5. R&D for State of Art Biomedical Optics Techniques
6. R&D in Orthopedic and Dental Fields
7. Basic R&D toward Therapeutic Apparatus
8. R&D Based Home Medical CareII. Medical Engineering for Society II:
Eight lecturers from 7 companies (14periods)
Theme of class:
1. Effective Visualization of Information for Integrated Medical System
2. Building social infrastructure for healthy, ageless society
utilizing the brain information cloud
3. Safety and Human Factors of Car Driving
4. Collaboration for Social Experiments
5. Global Technological Development and Marketing Strategy on
Healthcare Business
6. Big Data Applications for Healthcare, andCreation of New Societal Systems
7. Strategies to Improve Health through Daily Life Environment
III. Intellectual Property & Global Standardization
Nine lecturers from an independent administrative agency, public organizations, anda company + Kyoto University Staff
Theme of class:
1. Management of Technology and IP for Health Care Industry
2. R&D and Management of Technology and IP
3. Innovative Drug Development 1, Exploring Stage
4. Innovative drug development 2, Clinical Stage
5. Medial administration for drug development
6. Global standardization of Medical devices
7. Major International Standards
8. Regulation of Medical Devices
9. Regulation of Medical Devices/ International Development ofMedical Devices
10. An Aspect of Medical Engineering
11. New Industries of Biomedical Informatics
12. Models of Start-up Business
13. Development of Start-up Business
14. International harmonization of IP
145

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⦅㞟ᚋグ

 ึࡵ࡚ࡢᖺሗసࡾࡣ័ࢀ࡞࠸ࡇ࡜ࡤ࠿ࡾ࡛ࠊẼࡀࡘࡃ࡜♲ᅬ⚍ࡀ࡜࠺ࡢ᫇࡟
㐣ࡂࠊ኱ᩥᏐࡲ࡛⤊ࢃࡗ࡚ࡋࡲ࠸ࡲࡋࡓࠋ᮶ᖺࡣࠊᱜࡢ㡭ࡣ↓⌮࡜ࡋ࡚ࡶ㸦ᬮ໬࡛㛵す࡛ࡶ㸱᭶࠿ࡽဏࡁࡲࡍࡋ㸧ࠊ⣸㝧ⰼࡢ㡭࡟ࡣ࠾ᒆࡅ࡛ࡁࡿࡼ࠺࡟ࡋࡓ
࠸࡜ᛮ࠸ࡲࡍࠋ(M. N.) LIMS ࡟ᦠࢃࡗ࡚ 2 ᖺࡀ㐣ࡂࡲࡋࡓࠋ୍ᮇ⏕ࡢሗ࿌᭩ෆᐜࡣࡑࢀࡒࢀ῝ࡳࡀቑࡋࠊࡲࡓ LIMS ෆࡢᏛ⏕ࡉࢇࡢ㐃ᦠࡀཷ㈹࡟⧅ࡀࡿ࡞࡝ࠊᡂ㛗࡟ࡣ┠ࢆぢᙇࡿࡶࡢࡀ࠶ࡾࡲࡍࠋᏛ⏕ࡉࢇ࡟㈇ࡅ࡞࠸ࡼ࠺⮬ศ⮬㌟ࢆ☻ࡃ࡜ඹ࡟ࠊ୍⥴࡟㠃ⓑ࠸ࡇ࡜ࡀ࡛ࡁࡓࡽ࠸࠸࡞࠵࡜ᛮࡗ࡚࠸ࡲࡍࠋ(Y. H.)

Postscript

We first apologize for this late publication. Not only Gion-matsuri but also Daimonji
has already passed. Next year we will finish this work and deliver our annual report toyou before the hydrangea season. (M. N.)

Two years have passed since I started working in LIMS. LIMS students have shown
remarkable progress as reflected in their annual reports, which has also led to thestudents receiving an award for their work based on their LIMS project. As well asbrushing up teaching and research skill, I hope together with the students we can makeinteresting research. (Y. H.)

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学際融合教育研究推進センター
健康長寿社会の総合医療開発ユニット
京都市左京区吉田近衛町

Center for the Promotion of Interdisciplinary Education and Research
Research and Educational Unit of Leaders for Integrated Medical System (LIMS)
Konoe, Yoshida, Sakyo, Kyoto
http://www.lims.kyoto-u.ac.jp/