List of Research projects Conducted by Academic Advisors (Applied Natural Medicine)
Educational area
Responsible teacher
Research contents
Contact address
Neuromedical・Elucidation of the molecular mechanism of restoring the neuronal network, and crosstalk
Sciencebetween the central nervous system and peripheral organs to activate neural function.
Professor
・Traditional medicine research for developing fundamental therapeutic drugs for Alzheimer’s
TOHDA Chihiro
disease, spinal cord injury, cervical spondylosis myelopathy, glaucoma, and sarcopenia.
(Sugitani Campus)
chihiro@inm・Clinical study aiming to develop new botanical drugs and new usage of Kampo formulas.
・Clinical study to analyze factors affecting physical and mental health and to identify
biomarkers of wellbeing.
・Consilienceology for Wakan-yaku 1) Diagnosis for functional mental diseases based on theWakan-yaku response, and clarification of molecular mechanisms for the diseases2) Development of novel Wakan-yaku prescriptions to prevent lethal recurrence of heart
failureHost Defences
Professor
HAYAKAWA
Yoshihiro(Sugitani Campus)
haya@inm・Study of NK cell biology and its roles in immunity
・Role of innate immune responses in cancer progression
・Immunological study of inflammatory & allergic diseases
・Modulation of immune responses and immunological diseases by Kampo medicines
・Study to regulate cancer progression & metastasis
・Elucidation of novel actions of kampo medicines and food factors on the basis of modulationof intraluminal bile acid metabolism in gastrointestinal tract

Medicinal Resource
ScienceProfessor
SHOJI Tsubasa
tsubasa@inm

1. Molecular regulation of alkaloid and terpenoid pathways in medicinal plants of theSolanaceae family.
2. Novel regulatory mechanisms of alkaloid pathways in tobacco plants.
3. Biosynthesis and accumulation of natural sweeteners.
4. Collaborate with industry partners to apply our research to the stable supply andproduction of herbal medicines.

Natural Products& Drug Discovery
Professor
MORITA Hiroyuki(Sugitani Campus)
hmorita@inm

・Studies on biosynthesis of naturally occurring bioactive compounds
・Structural basis for secondary metabolite enzymes
・Enzyme engineering for novel drug development
・Isolation of bioactive compounds from plants, microorganisms, and marine organisms
・Investigation of Asia’s natural resources not fully utilized・Discovery of natural anticancer agents from medicinal plant resources by employing a novelantiausterity screening strategy
・Chemical investigation of medicinal plants and search for novel bioactive secondary
metabolites
・Investigation of the structure-activity relationship of the active natural compounds and theirmechanism of action against cancer cell survival pathways
・Discovery of metabolomics biomarkers associated with cancer cells by utilizing FT-NMRand MS strategy

Complex Biosystem
ResearchProfessor
NAKAGAWA Yoshimi(Sugitani Campus)
ynaka@inm

・Functional analysis of transcription factors that regulate glucose and lipid metabolism
・Study for nutrient metabolism regulation by cell-cell and tissue-tissue interaction
・Study for the molecular mechanism of improvement of lifestyle-related diseases by Wakanyaku
・Study for the mechanism of lifestyle-related diseases caused by sleep disorders
・Establishment of information science analysis using integrated omics analysis１

Educational area
Responsible teacher
Contact address
PresymptomaticDisease
Professor
KOIZUMI Keiichi(Sugitani Campus)
kkoizumi@inm

Research contents
・Understanding of the fluctuation of biometric information and its medical applications.
・Development of the glutaminase inhibitor and its medical applications.
・Elucidation of the function of immunostimulatory nanoparticles and nucleotide degradantdiscovered by traditional Japanese medicine (Kampo formula) and their medical applications.
・Elucidation of the pathological mechanism and the search for new seeds of medicine for
medical applications in enteric immune diseases.

ClinicalPharmaceutics
Professor
KATO Atsushi(Sugitani Campus)
kato@medEngineering based on
Genetic Information
Professor
KUROSAWA Nobuyuki(Gofuku Campus)
kurosawa@eng
Synthetic and MedicinalChemistryProfessor
ABE Hitoshi(Gofuku Campus)
abeh@eng

・Drug seed discovery research and evaluation of drugs targeting diabetes, allergic disorders,and other illnesses centered on glycomimetic alkaloids and herbal medicine-derived
compounds
・Biochemical research concerning glucolipid metabolic disorders focused on the propertiesof glycoproteins, glycohydrolases, and glycosyltransferases
・Development of platform technology for the production of monoclonal antibodies against
difficult antigens.
・Development of monoclonal antibodies for next-generation treatment and diagnosis

This field focuses on creation of novel “functional organic molecules” based on the advanced
synthetic organic chemistry. The newly designed organic molecules possess some potential tocontribute to various fields of science such as discovery of novel medicines andagrichemicals. Research in our group is primarily aimed toward the development of catalytic
reactions and methods for organic synthesis for the functional organic molecules.

Pharmacology
Associate Professor
TAKASAKI Ichiro(Gofuku Campus)
takasaki@eng

・Elucidation of the mechanisms of chronic pain/pruritus, neuropsychiatric disorders, cancer,

BiofunctionalChemistry
Professor
IKAWA Yoshiya(Gofuku Campus)
yikawa@sci

RNAs play versatile roles in biological systems because they not only serve as a genetic
material but also act as functional molecules. We study the molecular basis of naturally
occurring RNAs with catalytic and receptor functions. Another interest of our group lies in theartificial generation of RNAs with desirable functions through rational and evolutional
approaches.

Cell Biology
Professor
KARAHARA Ichirou(Gofuku Campus)
karahara@sci

Studies on the mechanisms of plants' responses to various terrestrial / cosmic environmental
factors at organ / tissue level using various morphological techniques including threedimensional macroscopic / ultrastructural analyses

etc.
・Drug discovery of novel small-molecule therapeutics
・Pharmacological analysis of the new small-molecule compounds

・A portion of email address is listed in the contact address. Please use it for preliminary consultations with the relevant
academic advisor in the field of your choice. Please add ".u-toyama.ac.jp" after the address.
Example) abc@def →abc@def.u-toyama.ac.jp２