Raw material exclusively for cosmetic manufacturing

Botanical Cosmetic Raw Material

LaFrance Koken
PYRUS COMMUNIS(PEAR) TWIG EXTRACT

LaFrance Koken is a cosmetic ingredientof plant extract extracted from twigs of
La France from Yamagata Prefecture.

Characteristics
Moisturizing eﬀect

Botanical ingredient which has equivalentmoisturizing eﬀect as glycerin.

Anti-aging eﬀect

Has an eﬀect to remove reactive oxygen,
which is considered to cause skin aging.

Applications: Lotions, essences, creams, etc.

LaFrance Koken
Analysis of antioxidant
eﬀectsWater content instratum corneum(μs)

Moisturizing eﬀect (skin)
LaFrance Koken
Glycerin50

0.08

Puriﬁed water

400.043020IC50（%）0Before
application

5 min

30min

60min

Approximately 0.05 mL of LaFrance Koken (undiluted solution), glycerin (20%) and puriﬁed
water were separately applied to the skin on the inner side of the forearm, and the watercontent of the stratum corneum (= keratin moisture) prior to application and from 5 to 60
minutes after wiping oﬀ the solutions was measured using a keratin moisture meter(Corneometer®CM825MP) (N=12, room temperature 19-23°C, humidity 40-48%). The results
showed that keratin moisture was approximately the same for LaFrance Koken and glycerinfrom 5 to 60 minutes after wiping oﬀ, indicating that LaFrance Koken provides an excellent
moisturizing eﬀect.
From in-house data

Antioxidant eﬀect was evaluated by singlet oxygen
scavenging activity assay. LaFrance Koken has twice
as strong as singlet oxygen scavenging activity thanarbutin.

Inhibitory eﬀects on
tyrosinase activity

From in-house data

Inhibitory eﬀects on
melanin production

Arbutin

60100Melanin Production %Inhibition rate ％LaFrance Koken

ArbutinElapsed time

LaFrance Koken

402001.53153060

100ConcentrationmM

The inhibitory eﬀect of LaFrance Koken on tyrosinase
activity, a melanin production facilitator, has been
analyzed. LaFrance Koken containing 100mM arbutin
was found to inhibit >about 60% of tyrosinase activity.
From in-house data

Safety evaluation

80Control

LaFrance Koken

ArbutinEﬀects on melanin production by melanin-producing cells inhuman epidermis(melanocytes) have been analyzed. The
inhibitory eﬀects of the addition of 0.9% of LaFrance Koken
on melanin production were conﬁrmed to be approximately
15% higher than those of the reagent arbutin at the same
concentration.
From in-house data

Human patch test : Negative

Product No.

Product Name

INCI Name

Other ingredient

Package

LWE-121

LaFrance Koken PE

WATER, PHENOXY ETHANOL

LWE-131

LaFrance Koken BG

PYRUS COMMUNIS(PEAR)
TWIG EXTRACT

WATER, BUTYLENE GLYCOL

1kg

The content in this document is prepared based on documents and experimental data available at the time; however, the content does not comprise a quarantee. Please
note in advance that the content described in this document may be changed depending on the circumstances. All intellectual property rights including copyrights anddesign rights of data described here and related documents belong to Koken Co., Ltd., and any unauthorized reproduction, reprinting or citation is strictly prohibited. Pleaserefer to the MSDS of the product in advance for the safe use of these ingredients. In addition, care should be taken to comply with the laws and regulations related to thePharmaceutical Aﬀairs Law in each country on expressions concerning consumer products.
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