APPLNOIATICTENO

Application Note/// Grinding of traditional Chinese medicine
with a high sugar content
PRODUCT
Tube Mill 100 control (Ident. no.: 0020007144)
MultiDrive control (Ident. no.: 0025002643)

INDUSTRY
Inspection of Medicines

OVERVIEW
The requirement was to grind traditional Chinese medicine
according to the guidelines outlined in the Chinese pharmacopeia
to ensure the accuracy of the test results.
Chinese medicinal materials refer to the raw materials ofmedicinal plants, animals and minerals, most of which come fromplants. There are 2711 kinds of traditional Chinese medicine shownin the Chinese pharmacopoeia (2020 Edition), of which 117 are
newly added and 452 are revised. This new edition has furtherimproved the quality control methods and standards. In terms ofsafety, it has updated the detection methods and limit standardsof pesticide residues, heavy metal pollution, mycotoxins, etc.
In terms of effectiveness, it has strengthened the research on
content determination and characteristic atlas, which provides
a strong guarantee for safe and efficient use.

SAMPLE MATERIAL 1Goji berry
Traditional Chinese medicine with a high sugar content

EXPERIMENTAL SETUP / SETTINGSMillTube Mill 100 control

Grinding chamber

MT 40.10

Speed

25,000 rpm

Grinding time

Intermittent grinding for 4 times,
15 seconds each time

Sample quantity

10 g

WWW.IKA.COM| Page 1/4

AP
PLNOI
AT
ICTE
NO

RESULTS
1. The goji berries can be ground without previous freeze drying but the sample will tend to clump.		

Before grinding

After grinding

2. The powdered sample can be obtained by grinding with dry ice.		

Before grinding

After grinding

Tip: Dry ice can be directly added to the MT 40 / MT 100 disposable grinding chamber and mixed
with the sample in order to make it brittle. The grinding can be done without waiting for the dry
ice to evaporate.

WWW.IKA.COM| Page 2/4

AP
PLNO

I
AT
ICTE
NO

The MultiDrive control offers a patented temperature
measurement and vessel recognition using RFID.
A temperature limit can be set for temperaturesensitive materials, or for specific planned reactions
to protect against sample overheating.

SAMPLE MATERIAL 2
Root tuber of the Chinese foxglove plant
Traditional Chinese medicine with a high sugar content

EXPERIMENTAL SETUP / SETTINGS
Grinder

MultiDrive control

Grinding Chamber

MI 400 T

Grinding Blade

BL 2000.1

Speed

20,000 rpm

Sample quantity

100 g

PROCEDURE
1. Cut the samples into approximately 1 cm sized pieces
2. Rough grinding for 20 seconds
3. Dry the smaller-sized samples until the sample weight isconstant to remove all moisture
4. S amples are ground intermittently for 6 consecutive times,
10 seconds each time

WWW.IKA.COM| Page 3/4

AP
PLNOIATICTENORESULTS
The powdered sample can only be obtained using the procedure listed above. This is to preventthe samples from sticking together after the grinding process and from adhering to the walls ofthe grinding chamber.			

Before grinding

After rough grinding

Grinding after drying

CONCLUSION
In order to achieve a powdered sample at the end of the grinding process for these types of samples
with a high sugar content, there are two recommended methods to choose from:
1. Grinding the sample together with dry ice, or
2. Pre-drying the sample to remove all moisture prior to grinding.

IKA Works (Asia) Sdn Bhd
Lot PT6445, Jalan Industri 3/4, Rawang Integrated
Industrial Park 48000 Rawang, Selangor, Malaysia
Phone: +60 3 6099-5666, Fax: +60 3 6092-0193,
eMail: sales.lab-ana@ika.my

www.ika.com

IKA(SoutheastAsia) // #lookattheblue| Page 4/4