学術セミナー
Biomimetic protein bioconjugates for biomaterials
and artificial organelles design
Prof. Dr. Sébastien Lecommandoux
University of Bordeaux, France

以下の予定でオンラインセミナーを開催します。
参加ご希望の方は、7/21正午までに事前登録をお願いします。

Summary:

日時： 2023年7月24日 (月) 14時（13:45より開場致します）
演者： Prof. Dr. S. Lecommandoux
フランス・ボルドー大学 教授
Biomacromolecules / ACS
Chief Editor
言語： 英語
事前登録サイト：https://forms.gle/ZJwQ6Ny3Kyfu5agc9

We report here an overview on the design of Elastin Like Polypeptides (ELPs) based
conjugates and their applications in nanomedicine, biomaterials and artificial cells. We pay
special attention to their modification with saccharides [1], polysaccharides [2] and lipids[3], aiming at mimicking both the structure and functionality of glycoproteins andlipoproteins. We developed synthetic strategies for the design of glycosylated polypeptides
and polysaccharide-polypeptide biohybrids with controlled placement of sugar functionality.
The ability of these systems for different biomedical applications, from drug-delivery toinhibitor, will be presented [4]. In addition, the design of a new class of lipoproteins basedon ELPs with unique thermo-responsive character will be proposed. These biosynthetic
lipoproteins can self-assemble into lipopolymersomes, with tunable membrane permeability,
opening avenues in drug delivery and artificial cell design [3]. Finally, our most recent
advances in the design of complex, compartmentalized and functional artificial cells will bepresented. Such a system is a first step towards the challenge of structural cell mimicry andfunctionality, and could act in the future as an autonomous artificial cell capable of detecting
and healing in situ any biological deregulation [5-7].

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学術セミナー[1] Design of Thermoresponsive Elastin-Like Glycopolypeptides for Selective Lectin Binding andSorting
LM. Bravo Anaya et al. Biomacromolecules 22, 76-85 (2021).
https://doi.org/10.1021/acs.biomac.0c00374[2] Aqueous synthesis and self-assembly of bioactive and thermo-responsive HA-b-ELP bioconjugates
M. Levêque et al. Biomaterials Science 10, 6365-6376 (2022).
https://doi.org/10.1039/D2BM01149B[3] Thermosensitive Vesicles from Chemically Encoded Lipid-Grafted Elastin-like Polypeptides
V Ibrahimova et al. Angew. Chem. Int. Ed. 60, 15036-15040 (2021).
https://doi.org/10.1002/anie.202102807[4] Hyaluronic-Acid-Presenting Self-Assembled Nanoparticles Transform a Hyaluronidase HYAL1
Substrate into an Efficient and Selective Inhibitor
H. Duan et al. Angew. Chem. Int. Ed. 59, 13591-13596 (2020).
https://doi.org/10.1002/anie.202005212[5] Dynamic Spatial Formation and Distribution of Intrinsically Disordered Protein Droplets inMacromolecularly Crowded Protocells
H. Zhao et al. Angew. Chem. Int. Ed. 59, 11028-11036 (2020).
https://doi.org/10.1002/anie.202001868[6] Spatiotemporal Dynamic Assembly/Disassembly of Organelle-Mimics Based on Intrinsically
Disordered Protein-Polymer Conjugates
H. Zhao et al. Advanced Science 2102508 (2021).
https://doi.org/10.1002/advs.202102508[7] Control of Enzyme Reactivity in Response to Osmotic Pressure Modulation Mimicking Dynamic
Assembly of Intracellular Organelles
C. Schwartzman et al. Advanced Materials 202301856 (2023).
https://doi.org/10.1002/adma.202301856

Sébastien Lecommandoux received his Ph.D. (1996) in Physical Chemistry from the University ofBordeaux. After a postdoctoral experience at the University of Illinois (UIUC, USA) in the group of Prof.
Samuel I. Stupp, he started his academic career at the Laboratoire de Chimie des Polymères Organiques
as Associate Professor in 1998 and was promoted to Full Professor at Bordeaux INP in 2005. He iscurrently Director of the Laboratoire de Chimie des Polymères Organiques (LCPO-CNRS) and is leading
the group “Polymers Self-Assembly and Life Sciences”. His research interests include the design of bioinspired polymers for biomaterials and pharmaceutical develoment, especially based on polypeptide,proteins and polysaccharide-based block copolymers self-assembly, the design of polymersomes for
drug-delivery and theranostic, as well as biomimetic approaches toward design of synthetic viruses andartificial cells. He published over 200 publications in international journal, 6 book chapters and 12patents (2 being licenced), with over 17000 citations (h-factor 65, Google Scholar). He is also co-directorof the joint laboratory LCPO-L'OREAL and co-founder of Emissary Cosmetics. Sébastien
Lecommandoux is recipient of the CNRS bronze medal (2004), Institut Universitaire de France JuniorChair (IUF 2007), Fellow of the Royal Society of Chemistry RSC (2017), Seqens Award of the French
Academy of Science (2019), Member of the Academia Europaea (2020), XingDa Lectureship Award
from Peking University (2021). He has been Editor-in-Chief of Biomacromolecules (ACS) since 2020
after serving as Associate Editor since 2013. He is also in the Editorial Advisory Board of several
international journals, including Bioconjugate Chemistry (ACS), Polymer Chemistry (RSC) andBiomaterials Science (RSC).