Implementation of“In-Body Hospitals”by open innovation

Open Innovation system,
which facilitates industry-academic-government collaboration.
This project, as “Center of Open Innovation Network for Smart Health” aims to realize a new platform, where eachparticipating research institutes can accelerate their collaboration, and moreover, create new innovation via industryacademia collaboration, which could not succeed in industry and university alone.
“In-Body Hospitals” is a futuristic technology that
effectively suppresses diseases of heavy social burden,
allowing people to live naturally healthy lives,
without the need for human labor to maintain their health.

iCONM supports COINS’ cutting-edge research
The Innovation Center of NanoMedicine (iCONM) was adopted by the Ministry of Education, Culture, Sports,
Science and Technology’s (MEXT) “Improvement of international science innovation bases using local resources
via industry-university collaboration,” and started operation in Apr. 2015. Equipped with state-of-the-art facilities andexperiment apparatus that allows for carrying out R&D related to organic synthesis, fine processing and preclinicalstudies, it is a one-of-a-kind research center that aims to promote open innovation through industry-universitygovernment and medical-engineering collaboration.

iCONM’s Vision
iCONM aims to:・Become the hub of Keihin-area Health Kombinat;
・Be the civic pride of Kawasaki;・Continuously create
new medical technology realizing human dream;・Become the world’s most innovative
research center.

Lo

op

KING SKYFRONT: Tonomachi’s International Strategic Hub

Being “under the one roof”
accelerates innovation

B.C.
950-710

Capsuletype
endoscope
2001

Co

Loop

Road

Tokyo Monorail
No.8

The Tama River

KING SKYFRONTTokyo Medical University

Nitto Denko Corporation
Tonomachi
Dai2 Park④

Shimogawara
Park

9
0940
4te
utReoul oRnoal
ati
na
tioN

Na

n

tio

ec

s

ad

ro

Haneda Airport International
Passenger Terminal
ailTokyo Monor

A Innovation Centere of NanoMedicine(iCONM)
B Research Gate Building TONOMACHI 2 (RGB2)
C Medtronic Japan Co. Ltd
D Research Gate Building TONOMACHI 1 (RGB1)
E Life Science & Environment research center (LiSE)
F Central Institute for Experimental Animals
G FUJIFILM Toyama Chemical Co., Ltd.
H Kawasaki King Skyfront Tokyu REI HotelI Johnson & Johnson K.K.
TheAssociation
J Japan Radioisotope
Ta
K Life Innovation Center (LIC)ma
Rive
L PeptiDream Inc.
r
M National Institute of Health Sciences
N Create Medic Co., Ltd.
Not yet constructed① CYBERDINE, Inc.
② JSR Corp.
③ Kawasumi Laboratories, Inc.
④ Shimadzu Corp.

*As of September 2020

Kaw
hi
a K
mac
Tono ce/Exit Me sakiaLw
inaes,a
trop
an
k
oliM
Entr
tan
etrKai nLain
gaw
Eo
xp
,K
proe eaNlsitsawnayanoa.6
Exp ga, w
res a Nosw
ay .6,iCONM is situated at KING SKYFRONT,
a designated national strategic specialzone. The approximately 40-hectaresite is located to the southwest of
Haneda International Airport, on the
opposite shore of the Tama River. Theinternational strategic hub’s formation
is in full progress, and new industries
are being created through R&D at thehighest level in the fields of life sciencesand environment.
The area was named “KING SKYFRONT”- the “King” is an acronym of “Kawasaki
INnovation Gateway” and “Tonomachi”( “ Tono” refer ring to the Japaneseword “king”) - and will lead in Japan’s
progress as a nation, and contribute to
global sustainable development.

Forefront technology
to the world

COINS aims to realize “In-Body Hospitals”, which integrates all medical functions within the
body. Smart nanomachines of a virus size will autonomously patrol the microenvironments inthe body and provide diagnostic and therapeutic services 24 hours a day.

Implantableartificial
heart
1982

.8

nn

Toward realization of “In-Body Hospitals”

Extracorporeal
artificial kidney(dialyzer)
1943

No

Tenkūbashi Sta.

Research goals and approaches at COINS

Crutchesad

CCoonnnnee
ccttioionn rroo
aaddssWith the concept of “under the one roof ”,
The Innovation Center of NanoMedicine(iCONM) tries to establish the shared use of
research equipment, research spaces anddry laboratories to promote active interaction
among researchers. Researchers fromCOINS participating institutions constantly
challenge one another in open innovation,and social implemention is expected toaccelerate via new breakthroughs.

Ro

KING SK YFRONT is positioned in the
Keihin Seaside area, where the Keihininternational trade port is also located, near
Haneda International Airport. It is connectedwith major highway network systems, and isaccelerating collaboration between Japan
with the rest of the world.

Detection

Innovation

Evolution of medical instrument(downsizing, high functionality, minimal
invasiveness, etc.)‟Monster on the line
38 degrees”
1954, Japan(Osamu TEZUKA)
Illustrated an idea of reducing
the size of a physician
and sending him inside the body

World of science fiction

Transform the worldof science fiction

Treatment

Diagnosis

smart nanomachine and in-body hospitals are the trademarks of Kawasaki Institute of Industrial Promotion.
in-body hospitals; registered in Japan

http: //coins.kawasaki-net.ne.jp/‟Fantastic
Voyage”

Realization

1966, USA

Smart nanomachineof a virus size
20XX

All functions are integrated insidehuman body.

KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
Center of Open Innovation Network for Smart Health (COINS)Innovation Center of NanoMedicine (iCONM)
3-25-14,Tonomachi,Kawasaki-ku,Kawasaki 210-0821 Japan
Tel.+81- 44 -589-5785 Fax.+81-44 -589-5789
2 0 2 0 .1 0 -E 0 1 3

Message
Project Leader of COINSKAWASAKI INSTITUTE OF
INDUSTRIAL PROMOTION
Innovation Center of
NanoMedicine (iCONM)

Director General andResearch Leader of COINSKAWASAKI INSTITUTE OF
INDUSTRIAL PROMOTION
Innovation Center of
NanoMedicine (iCONM)

Hiromichi KIMURA

Kazunori KATAOKA

Professor,
The University of Tokyo

Six approaches toward the realization of “In- Body Hospitals”

Targeting cancer, dementia and other ailments that tend to develop withhuman aging, COINS has six approaches (or themes) for the realizationof “In-Body Hospitals”.

Professor,
The University of Tokyo

Located in the Keihin manufacturing district, a praised area forindustrial promotion, and facing Tokyo Haneda International Airport,
a hub of Japan, a new healthcare industry has been established,
whose first few steps have been attracting worldwide interest.
A diversity of human resources, funds and cutting-edge technologies
has been brought together from around Japan and the world with theaim of “making the impossible possible”. Smart nanomachines, which
is designed based on unconventional ideas, is created to serve as “InBody Hospitals”, and solves the problems of curing and preventing
intractable diseases. Researchers from private companies, research
institutes, and universities joined under one-roof and fully dedicated tothis mission. From this, the management strategy team is constructing a
globally recognized cutting-edge social system. It is the arrival of startup companies, products and services to be born one after another.

A truly innovative element of this project is that it realizes anautonomous health society ( smart health society ) byliberating anyone, anywhere and anytime from diseases ofheavy social burden without any regards to psychological,
physical or economic uncertainty. We aim to realize “In-Body
Hospitals”, which provides necessary diagnosis and treatment
inside the required parts of the body at the precise time, by
creating “smart nanomachines the size of a virus size, whichautonomously patrol the microenvironments in the body”.
This has been mere science fiction until now, but will bemade a reality by self-organization of macromolecules
integrated with functionals elements required for pin-point
diagnosis and targeted therapy.

The ﬁrst generation of anticancer drug-loaded nanomachines are alreadyin a Phase II clinical trials.
Shimadzu Corporation, Nitto Denko Corporation,

Vision/Mission

Project Associate Professor“In-Body Hospitals” − future technology COINS aims for
COINS (Center of Open Innovation Network for Smart Health) is a research center of an entirely new idea for developing “products
and services that changes the future” by anticipating social needs in the future and integrating cutting-edge technologies, humanresources and ideas from universities and private companies in and outside Japan.
COINS thinks that an answer is development of dream-like smart nanomachines that patrol around the body 24 hours a day,detect sign of a disease, treat the disease and immediately communicate the information to the outside body. Cutting-edge
nanomedical research institutes have joined from all parts of Japan and the world to facilitate industry-academia-government
collaboration toward development of nanomachines.

COINS is an initiative under the Center of Innovation Science andTechnology based Radical Innovation and Entrepreneurship Program (COI STREAM)of the Ministry of Education, Culture, Sports, Science and Technology, Japan.
“COINS” also implies being a center of frequent “coincidences” and many people in the world not needing bills
but “coins” to have an access to medical service. The hexagons above the “I” in the logotype represent mutually
overlapping wings, connoting “creation of new values and innovation via integration of different fields,”“butterflies gathering to Haneda Airport (which is in the vicinity of the center) and flying to all parts of theworld,” and “smoke of innovation rising from a smokestack, symbolizing changes in the Keihin Industrial area”.

Toray Industries, Inc.,

Development of vaccines against viruses including COVID-19 using
this technology are also tbeing carried out.
Tokyo Medical University,
NanoCarrier Co., Ltd.

Implementation of“In-Body Hospitals”by open innovation

Open Innovation system,
which facilitates industry-academic-government collaboration.
This project, as “Center of Open Innovation Network for Smart Health” aims to realize a new platform, where eachparticipating research institutes can accelerate their collaboration, and moreover, create new innovation via industryacademia collaboration, which could not succeed in industry and university alone.
“In-Body Hospitals” is a futuristic technology that
effectively suppresses diseases of heavy social burden,
allowing people to live naturally healthy lives,
without the need for human labor to maintain their health.

iCONM supports COINS’ cutting-edge research
The Innovation Center of NanoMedicine (iCONM) was adopted by the Ministry of Education, Culture, Sports,
Science and Technology’s (MEXT) “Improvement of international science innovation bases using local resources
via industry-university collaboration,” and started operation in Apr. 2015. Equipped with state-of-the-art facilities andexperiment apparatus that allows for carrying out R&D related to organic synthesis, fine processing and preclinicalstudies, it is a one-of-a-kind research center that aims to promote open innovation through industry-universitygovernment and medical-engineering collaboration.

iCONM’s Vision
iCONM aims to:・Become the hub of Keihin-area Health Kombinat;
・Be the civic pride of Kawasaki;・Continuously create
new medical technology realizing human dream;・Become the world’s most innovative
research center.

Lo

op

KING SKYFRONT: Tonomachi’s International Strategic Hub

Being “under the one roof”
accelerates innovation

B.C.
950-710

Capsuletype
endoscope
2001

Co

Loop

Road

Tokyo Monorail
No.8

The Tama River

KING SKYFRONTTokyo Medical University

Nitto Denko Corporation
Tonomachi
Dai2 Park④

Shimogawara
Park

9
0940
4te
utReoul oRnoal
ati
na
tioN

Na

n

tio

ec

s

ad

ro

Haneda Airport International
Passenger Terminal
ailTokyo Monor

A Innovation Centere of NanoMedicine(iCONM)
B Research Gate Building TONOMACHI 2 (RGB2)
C Medtronic Japan Co. Ltd
D Research Gate Building TONOMACHI 1 (RGB1)
E Life Science & Environment research center (LiSE)
F Central Institute for Experimental Animals
G FUJIFILM Toyama Chemical Co., Ltd.
H Kawasaki King Skyfront Tokyu REI HotelI Johnson & Johnson K.K.
TheAssociation
J Japan Radioisotope
Ta
K Life Innovation Center (LIC)ma
Rive
L PeptiDream Inc.
r
M National Institute of Health Sciences
N Create Medic Co., Ltd.
Not yet constructed① CYBERDINE, Inc.
② JSR Corp.
③ Kawasumi Laboratories, Inc.
④ Shimadzu Corp.

*As of September 2020

Kaw
hi
a K
mac
Tono ce/Exit Me sakiaLw
inaes,a
trop
an
k
oliM
Entr
tan
etrKai nLain
gaw
Eo
xp
,K
proe eaNlsitsawnayanoa.6
Exp ga, w
res a Nosw
ay .6,iCONM is situated at KING SKYFRONT,
a designated national strategic specialzone. The approximately 40-hectaresite is located to the southwest of
Haneda International Airport, on the
opposite shore of the Tama River. Theinternational strategic hub’s formation
is in full progress, and new industries
are being created through R&D at thehighest level in the fields of life sciencesand environment.
The area was named “KING SKYFRONT”- the “King” is an acronym of “Kawasaki
INnovation Gateway” and “Tonomachi”( “ Tono” refer ring to the Japaneseword “king”) - and will lead in Japan’s
progress as a nation, and contribute to
global sustainable development.

Forefront technology
to the world

COINS aims to realize “In-Body Hospitals”, which integrates all medical functions within the
body. Smart nanomachines of a virus size will autonomously patrol the microenvironments inthe body and provide diagnostic and therapeutic services 24 hours a day.

Implantableartificial
heart
1982

.8

nn

Toward realization of “In-Body Hospitals”

Extracorporeal
artificial kidney(dialyzer)
1943

No

Tenkūbashi Sta.

Research goals and approaches at COINS

Crutchesad

CCoonnnnee
ccttioionn rroo
aaddssWith the concept of “under the one roof ”,
The Innovation Center of NanoMedicine(iCONM) tries to establish the shared use of
research equipment, research spaces anddry laboratories to promote active interaction
among researchers. Researchers fromCOINS participating institutions constantly
challenge one another in open innovation,and social implemention is expected toaccelerate via new breakthroughs.

Ro

KING SK YFRONT is positioned in the
Keihin Seaside area, where the Keihininternational trade port is also located, near
Haneda International Airport. It is connectedwith major highway network systems, and isaccelerating collaboration between Japan
with the rest of the world.

Detection

Innovation

Evolution of medical instrument(downsizing, high functionality, minimal
invasiveness, etc.)‟Monster on the line
38 degrees”
1954, Japan(Osamu TEZUKA)
Illustrated an idea of reducing
the size of a physician
and sending him inside the body

World of science fiction

Transform the worldof science fiction

Treatment

Diagnosis

smart nanomachine and in-body hospitals are the trademarks of Kawasaki Institute of Industrial Promotion.
in-body hospitals; registered in Japan

http: //coins.kawasaki-net.ne.jp/‟Fantastic
Voyage”

Realization

1966, USA

Smart nanomachineof a virus size
20XX

All functions are integrated insidehuman body.

KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
Center of Open Innovation Network for Smart Health (COINS)Innovation Center of NanoMedicine (iCONM)
3-25-14,Tonomachi,Kawasaki-ku,Kawasaki 210-0821 Japan
Tel.+81- 44 -589-5785 Fax.+81-44 -589-5789
2 0 2 0 .1 0 -E 0 1 3

Message
Project Leader of COINSKAWASAKI INSTITUTE OF
INDUSTRIAL PROMOTION
Innovation Center of
NanoMedicine (iCONM)

Director General andResearch Leader of COINSKAWASAKI INSTITUTE OF
INDUSTRIAL PROMOTION
Innovation Center of
NanoMedicine (iCONM)

Hiromichi KIMURA

Kazunori KATAOKA

Professor,
The University of Tokyo

Six approaches toward the realization of “In- Body Hospitals”

Targeting cancer, dementia and other ailments that tend to develop withhuman aging, COINS has six approaches (or themes) for the realizationof “In-Body Hospitals”.

Professor,
The University of Tokyo

Located in the Keihin manufacturing district, a praised area forindustrial promotion, and facing Tokyo Haneda International Airport,
a hub of Japan, a new healthcare industry has been established,
whose first few steps have been attracting worldwide interest.
A diversity of human resources, funds and cutting-edge technologies
has been brought together from around Japan and the world with theaim of “making the impossible possible”. Smart nanomachines, which
is designed based on unconventional ideas, is created to serve as “InBody Hospitals”, and solves the problems of curing and preventing
intractable diseases. Researchers from private companies, research
institutes, and universities joined under one-roof and fully dedicated tothis mission. From this, the management strategy team is constructing a
globally recognized cutting-edge social system. It is the arrival of startup companies, products and services to be born one after another.

A truly innovative element of this project is that it realizes anautonomous health society ( smart health society ) byliberating anyone, anywhere and anytime from diseases ofheavy social burden without any regards to psychological,
physical or economic uncertainty. We aim to realize “In-Body
Hospitals”, which provides necessary diagnosis and treatment
inside the required parts of the body at the precise time, by
creating “smart nanomachines the size of a virus size, whichautonomously patrol the microenvironments in the body”.
This has been mere science fiction until now, but will bemade a reality by self-organization of macromolecules
integrated with functionals elements required for pin-point
diagnosis and targeted therapy.

The ﬁrst generation of anticancer drug-loaded nanomachines are alreadyin a Phase II clinical trials.
Shimadzu Corporation, Nitto Denko Corporation,

Vision/Mission

Project Associate Professor“In-Body Hospitals” − future technology COINS aims for
COINS (Center of Open Innovation Network for Smart Health) is a research center of an entirely new idea for developing “products
and services that changes the future” by anticipating social needs in the future and integrating cutting-edge technologies, humanresources and ideas from universities and private companies in and outside Japan.
COINS thinks that an answer is development of dream-like smart nanomachines that patrol around the body 24 hours a day,detect sign of a disease, treat the disease and immediately communicate the information to the outside body. Cutting-edge
nanomedical research institutes have joined from all parts of Japan and the world to facilitate industry-academia-government
collaboration toward development of nanomachines.

COINS is an initiative under the Center of Innovation Science andTechnology based Radical Innovation and Entrepreneurship Program (COI STREAM)of the Ministry of Education, Culture, Sports, Science and Technology, Japan.
“COINS” also implies being a center of frequent “coincidences” and many people in the world not needing bills
but “coins” to have an access to medical service. The hexagons above the “I” in the logotype represent mutually
overlapping wings, connoting “creation of new values and innovation via integration of different fields,”“butterflies gathering to Haneda Airport (which is in the vicinity of the center) and flying to all parts of theworld,” and “smoke of innovation rising from a smokestack, symbolizing changes in the Keihin Industrial area”.

Toray Industries, Inc.,

Development of vaccines against viruses including COVID-19 using
this technology are also being carried out.
Tokyo Medical University,
NanoCarrier Co., Ltd.

Implementation of“In-Body Hospitals”by open innovation

Open Innovation system,
which facilitates industry-academic-government collaboration.
This project, as “Center of Open Innovation Network for Smart Health” aims to realize a new platform, where eachparticipating research institutes can accelerate their collaboration, and moreover, create new innovation via industryacademia collaboration, which could not succeed in industry and university alone.
“In-Body Hospitals” is a futuristic technology that
effectively suppresses diseases of heavy social burden,
allowing people to live naturally healthy lives,
without the need for human labor to maintain their health.

iCONM supports COINS’ cutting-edge research
The Innovation Center of NanoMedicine (iCONM) was adopted by the Ministry of Education, Culture, Sports,
Science and Technology’s (MEXT) “Improvement of international science innovation bases using local resources
via industry-university collaboration,” and started operation in Apr. 2015. Equipped with state-of-the-art facilities andexperiment apparatus that allows for carrying out R&D related to organic synthesis, fine processing and preclinicalstudies, it is a one-of-a-kind research center that aims to promote open innovation through industry-universitygovernment and medical-engineering collaboration.

iCONM’s Vision
iCONM aims to:・Become the hub of Keihin-area Health Kombinat;
・Be the civic pride of Kawasaki;・Continuously create
new medical technology realizing human dream;・Become the world’s most innovative
research center.

Lo

op

KING SKYFRONT: Tonomachi’s International Strategic Hub

Being “under the one roof”
accelerates innovation

B.C.
950-710

Capsuletype
endoscope
2001

Co

Loop

Road

Tokyo Monorail
No.8

The Tama River

KING SKYFRONTTokyo Medical University

Nitto Denko Corporation
Tonomachi
Dai2 Park④

Shimogawara
Park

9
0940
4te
utReoul oRnoal
ati
na
tioN

Na

n

tio

ec

s

ad

ro

Haneda Airport International
Passenger Terminal
ailTokyo Monor

A Innovation Centere of NanoMedicine(iCONM)
B Research Gate Building TONOMACHI 2 (RGB2)
C Medtronic Japan Co. Ltd
D Research Gate Building TONOMACHI 1 (RGB1)
E Life Science & Environment research center (LiSE)
F Central Institute for Experimental Animals
G FUJIFILM Toyama Chemical Co., Ltd.
H Kawasaki King Skyfront Tokyu REI HotelI Johnson & Johnson K.K.
TheAssociation
J Japan Radioisotope
Ta
K Life Innovation Center (LIC)ma
Rive
L PeptiDream Inc.
r
M National Institute of Health Sciences
N Create Medic Co., Ltd.
Not yet constructed① CYBERDINE, Inc.
② JSR Corp.
③ Kawasumi Laboratories, Inc.
④ Shimadzu Corp.

*As of September 2020

Kaw
hi
a K
mac
Tono ce/Exit Me sakiaLw
inaes,a
trop
an
k
oliM
Entr
tan
etrKai nLain
gaw
Eo
xp
,K
proe eaNlsitsawnayanoa.6
Exp ga, w
res a Nosw
ay .6,iCONM is situated at KING SKYFRONT,
a designated national strategic specialzone. The approximately 40-hectaresite is located to the southwest of
Haneda International Airport, on the
opposite shore of the Tama River. Theinternational strategic hub’s formation
is in full progress, and new industries
are being created through R&D at thehighest level in the fields of life sciencesand environment.
The area was named “KING SKYFRONT”- the “King” is an acronym of “Kawasaki
INnovation Gateway” and “Tonomachi”( “ Tono” refer ring to the Japaneseword “king”) - and will lead in Japan’s
progress as a nation, and contribute to
global sustainable development.

Forefront technology
to the world

COINS aims to realize “In-Body Hospitals”, which integrates all medical functions within the
body. Smart nanomachines of a virus size will autonomously patrol the microenvironments inthe body and provide diagnostic and therapeutic services 24 hours a day.

Implantableartificial
heart
1982

.8

nn

Toward realization of “In-Body Hospitals”

Extracorporeal
artificial kidney(dialyzer)
1943

No

Tenkūbashi Sta.

Research goals and approaches at COINS

Crutchesad

CCoonnnnee
ccttioionn rroo
aaddssWith the concept of “under the one roof ”,
The Innovation Center of NanoMedicine(iCONM) tries to establish the shared use of
research equipment, research spaces anddry laboratories to promote active interaction
among researchers. Researchers fromCOINS participating institutions constantly
challenge one another in open innovation,and social implemention is expected toaccelerate via new breakthroughs.

Ro

KING SK YFRONT is positioned in the
Keihin Seaside area, where the Keihininternational trade port is also located, near
Haneda International Airport. It is connectedwith major highway network systems, and isaccelerating collaboration between Japan
with the rest of the world.

Detection

Innovation

Evolution of medical instrument(downsizing, high functionality, minimal
invasiveness, etc.)‟Monster on the line
38 degrees”
1954, Japan(Osamu TEZUKA)
Illustrated an idea of reducing
the size of a physician
and sending him inside the body

World of science fiction

Transform the worldof science fiction

Treatment

Diagnosis

smart nanomachine and in-body hospitals are the trademarks of Kawasaki Institute of Industrial Promotion.
in-body hospitals; registered in Japan

http: //coins.kawasaki-net.ne.jp/‟Fantastic
Voyage”

Realization

1966, USA

Smart nanomachineof a virus size
20XX

All functions are integrated insidehuman body.

KAWASAKI INSTITUTE OF INDUSTRIAL PROMOTION
Center of Open Innovation Network for Smart Health (COINS)Innovation Center of NanoMedicine (iCONM)
3-25-14,Tonomachi,Kawasaki-ku,Kawasaki 210-0821 Japan
Tel.+81- 44 -589-5785 Fax.+81-44 -589-5789
2 0 2 0 .1 0 -E 0 1 3