Active Motif Epigenetic Services Publications
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Technique

TargetJournalYear

Immunity2024

ChIP-Seq

RNA pol II

ChIP-Seq

H3K27Ac

Front Endocrinol. 2024

ChIP-Seq

WT1

Front Endocrinol. 2024

ChIP-Seq

RNA pol II,
H3K27ac

ChIP-Seq,
RNA-Seq

VGLL1

ATAC-Seq,
RNA-Seq
ChIP-Seq

NFIA

ChIP-Seq

H3K27me3, H3K4me3, H3K27ac

snRNA-Seq

ChIP-Seq

H3K4me3, H3K4me1, H3K27ac,
H3K27me3, p300

ChIP-Seq

CBP/p300

ChIP-Seq

PHF8

ChIP-Seq

H3K27me3,
H3K27ac, SUZ12

North America 877 222 9543

bioRxiv

2024

Front Oncol.

2024

bioRxiv

2024

bioRxiv

2024

Cancer Res Com2024
mun.
bioRxiv

2024

Nat Commun.

2024

bioRxiv

2024

Redox Biol.

2024

Nature2024

Europe +32 (0)2 653 0001

Reference

Alexander D Gitlin et al. N4BP1 coordinates ubiquitindependent crosstalk within the IκB kinase family to limit
Toll-like receptor signaling and inflammation. 10.1016/j.
immuni.2024.04.004
Raja Gopal Reddy Mooli et al. Epigenetically active
chromatin in neonatal iWAT reveals GABPα as apotential regulator of beige adipogenesis. DOI: 10.3389/
fendo.2024.1385811
David James et al. Homeobox regulator Wilms Tumour 1 isdisplaced by androgen receptor at cis-regulatory elementsin the endometrium of PCOS patients. DOI: 10.3389/
fendo.2024.1368494
Yusuke Suita et al. Machine learning on multiple epigenetic
features reveals H3K27Ac as a driver of gene expression
prediction across patients with glioblastoma. DOI:
10.1101/2024.06.25.600585
Heather M Sonnemann et al. Placental co-transcriptional
activator Vestigial-like 1 (VGLL1) drives tumorigenesis
via increasing transcription of proliferation and invasion
genes. DOI: 10.3389/fonc.2024.1403052
Suraj Bhattarai et al. H3F3A K27M Mutations Drives a
Repressive Transcriptome by Modulating Chromatin
Accessibility, Independent of H3K27me3 in Diffuse Midline
Glioma. DOI: 10.1101/2024.05.16.594522
Julia Gauberg et al. Spinal motor neuron development
and metabolism are transcriptionally regulated by Nuclear
Factor IA. DOI: 10.1101/2024.06.26.600888
Tanner J DuCote et al. EZH2 Inhibition Promotes Tumor
Immunogenicity in Lung Squamous Cell Carcinomas. DOI:
10.1158/2767-9764.CRC-23-0399
Gangyuan Gao et al. Polyunsaturated Fatty Acid mediated Cellular Rejuvenation for Reversing Age-related
Vision Decline. DOI: 10.1101/2024.07.01.601592
Mariko Sasaki et al. Targeting dependency on a paralog
pair of CBP/p300 against de-repression of KREMEN2 in
SMARCB1-deficient cancers. DOI: 10.1038/s41467-02449063-w
Sumaira Sardar et al. AR coactivators, CBP/p300, arecritical mediators of DNA repair in prostate cancer. DOI:
10.1101/2024.05.07.592966
Joanna Czarnecka-Herok et al. A non-canonical roleof ELN protects from cellular senescence by limiting irondependent regulation of gene expression. DOI: 10.1016/j.
redox.2024.103204
Makoto Yamagishi et al. Mechanisms of action andresistance in histone methylation-targeted therapy. DOI:
10.1038/s41586-024-07103-x
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Technique

JournalYear

RNA-Seq

iScience2024

snRNA-Seq

bioRxiv

2024

Nat Commun.

2024

ModSpec

Sci Adv.

2024

ATAC-Seq

Nature2024

ChIP-Seq

ChIP-Seq

TargetH3K27me3

FOXO1

ATAC-Seq

ChIP-Seq

H3K27me3, EZH2

ChIP-Seq

Hoxa5, Pbx1

ATAC-Seq,
RNA-Seq

Mol Cell Endocri2024
nol.
Life Sci Alliance

2024

Genome Biol.

2024

bioRxiv

2024

EMBO Rep.

2024

Cancer Res.

2024

snRNA-Seq

Aging Cell

2024

RNA-Seq

Cell Rep.

2024

RNA-Seq

iScience

2023

JCI Insight

2023

Genes (Basel)

2023

ChIP-Seq

H3K27ac

ChIP-Seq

Vitamin D Receptor

CUT&Tag

H3K9me3

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Clotilde C N Renaud et al. Necrosulfonamide causes
oxidation of PCM1 and impairs ciliogenesis and autophagy.
DOI: 10.1016/j.isci.2024.109580
Fangyuan Gao et al. Polyunsaturated Fatty Acid - mediated
Cellular Rejuvenation for Reversing Age-related Vision
Decline. DOI: 10.1101/2024.07.01.601592
Zoe Veneti et al. Polycomb-mediated silencing of miR8 is required for maintenance of intestinal stemness inDrosophila melanogaster. DOI: 10.1038/s41467-024-46119-9
Anthony KN Chan et al. Therapeutic targeting Tudor
domains in leukemia via CRISPR-Scan Assisted Drug
Discovery. DOI: 10.1126/sciadv.adk3127
Violetta Karwacki-Neisius et al. WNT signalling control
by KDM5C during development affects cognition. DOI:
10.1038/s41586-024-07067-y
Caitlin E Stallings et al. FOXO1 regulates expressionof Neurod4 in the pituitary gland. DOI: 10.1016/j.
mce.2023.112128
Shivakshi Sulekh et al. A feedback loop that drives cell
death and proliferation and its defect in intestinal stem
cells. DOI: 10.26508/lsa.202302238
Georgette Tanner et al. IDHwt glioblastomas can be
stratified by their transcriptional response to standard
treatment, with implications for targeted therapy. DOI:
10.1186/s13059-024-03172-3
KC Ritesh et al. Multimodal Hox5 activity generates motor
neuron diversity. DOI: 10.1101/2024.02.08.579338
Panagiotis Papoutsoglou et al. TGFβ-induced long noncoding RNA LINC00313 activates Wnt signaling andpromotes cholangiocarcinoma. DOI: 10.1038/s44319-02400075-z
Tathiane M Malta et al. The Epigenetic Evolution of Glioma
Is Determined by the IDH1 Mutation Status and Treatment
Regimen. DOI: 10.1158/0008-5472.CAN-23-2093
Spiros Palikyras et al. Rapid and synchronous chemical
induction of replicative-like senescence via a small
molecule inhibitor. doi: 10.1111/acel.14083
Clement Maghe et al. The paracaspase MALT1 controls
cholesterol homeostasis in glioblastoma stem-like cells
through lysosome proteome shaping. DOI: 10.1016/j.
celrep.2023.113631
Yufei Wei et al. Sirt6 regulates the proliferation of neuralprecursor cells and cortical neurogenesis in mice. DOI:
10.1016/j.isci.2023.108706
Yuan Wen et al. Vitamin D status associates with skeletal
muscle loss after anterior cruciate ligament reconstruction.
DOI: 10.1172/jci.insight.170518
Takahiro Sano et al. Impaired Repopulating Ability ofUhrf2-/- Hematopoietic Progenitor Cells in Mice. DOI:
10.3390/genes14081531

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique
ChIP

TargetH3K4me1

RRBS

JournalYear

Front Endocriinol. 2023
Cancers2023

ChIP-Seq

H3K79me2

Nat Immunol.

2023

ChIP-Seq

C/EBPαNat Commun.

2023

CUT&Tag,
RNA-Seq

H3K9Ac

Cells

2023

ChIP-Seq

CTCF

FASEB J.

2023

ChIP-Seq

AhR (aryl hydrocarbon receptor)

Toxicol Sci.

2023

ChIP-Seq,
RIME

H3K27ac

Life Sci Alliance2023

ChIP-Seq

Klf9

Cell Signal.

2023

J Virol.

2023

RIME
ChIP-qPCR

Myc

Mol Oncol.

2023

ChIP

H3K23PrJ Clin Invest.

2023

ChIP-Seq

PHF8

Sci Adv.

2023

ATAC-Seq

Sci Adv.

2023

ATAC-Seq,
hMeDIPSeq, RNASeq

Int J Dev Biol.

2022

ChIP-Seq

H3K27ac, PLAGL1,PLAGL2

North America 877 222 9543

Acta Neuropathol. 2023
Europe +32 (0)2 653 0001

Reference

Yeongseik Oh et al. The NR2F2-HAND2 signaling axis
regulates progesterone actions in the uterus at earlypregnancy. Doi: 10.3389/fendo.2023.1229033
Yomoki Yamamoto et al. DNA Methylation Aberrations in
Dimethylarsinic Acid-Induced Bladder Carcinogenesis. Doi:
10.3390/cancers15215274
Liangyu Lin et al. Oleic acid availability impacts thymocyte
preprogramming and subsequent peripheral Treg celldifferentiation. Doi: 0.1038/s41590-023-01672-1
Dongmei Wang et al. Homodimer-mediatedphosphorylation of C/EBPα-p42 S16 modulates acute
myeloid leukaemia differentiation through liquid-liquid
phase separation. Doi: 10.1038/s41467-023-42650-3
Shah Alam et al. S1P Lyase Deficiency in the Brain
Promotes Astrogliosis and NLRP3 Inflammasome
Activation via Purinergic Signaling. DOI: 10.3390/
cells12141844
Sylvia C Hewitt et al. Chromatin architectural factor
CTCF is essential for progesterone-dependent uterine
maturation. doi: 10.1096/fj.202300862R
David Filipovic et al. Interpretable predictive models of
genome-wide aryl hydrocarbon receptor-DNA binding
reveal tissue-specific binding determinants. DOI: 10.1093/
toxsci/kfad094
Victor Bessenneau_Gaborit et al. Exploring the impact ofdexamethasone on gene regulation in myeloma cells. doi:
10.26508/lsa.202302195
Chandni Thakkar et al. Klf9 plays a critical role in GR –dependent metabolic adaptations in cardiomyocytes. DOI:
10.1016/j.cellsig.2023.110886
Lauren McKenzie Spires et al. KSHV RTA utilizes thehost E3 ubiquitin ligase complex RNF20/40 to drive lytic
reactivation. DOI: 10.1128/jvi.01389-23
Marta Kazimierska et al. CRISPR/Cas9 screen for genomewide interrogation of essential MYC-bound E-boxes incancer cells. DOI: 10.1002/1878-0261.13493
Zhi Yang et al. Reducing branched-chain amino acids
improves cardiac stress response in mice by decreasing
histone H3K23 propionylation. doi: 10.1172/JCI169399
Song Peng et al. PHF8-GLUL axis in lipid deposition andtumor growth of clear cell renal cell carcinoma. DOI:
10.1126/sciadv.adf3566
Raisa A Reyes-Castro et al. Phosphorylated nuclear DICER1
promotes open chromatin state and lineage plasticity of
AT2 tumor cells in lung adenocarcinomas. DOI: 10.1126/
sciadv.adf6210
Rosa Guzzo et al. Single-cell transcriptomics defines Dot1L
interacting partners and downstream target genes in themouse molar dental pulp. DOI: 10.1387/ijdb.220141db
Michaela-Kristina Keck et al. Amplification of the PLAGfamily genes—PLAGL1 and PLAGL2—is a key feature of
the novel tumor type CNS embryonal tumor with PLAGL
amplification. 10.1007/s00401-022-02516-2
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China (86) 21 20926090

Technique

TargetRNA-Seq,
hMeDIPSeq

JournalYear

Cleft Palate Cra2023
niofac J.

RNA-Seq

bioRxiv

2023

Mod Spec

Cells

2023

J Mol Biol.

2023

Proc Natl Acad
Sci USA

2023

Nat Commun.

2023

Adv Sci.

2023

ChIP

Myc Tag

ATAC-Seq
ChIP-Seq

EralphaMod Spec

Int Immunophar2023
macol.

RNA-Seq

RNA-Seq

Cell Rep.

Hi-C

ChIP-Seq

2023
2023

H3K27ac

Epigenetics

2023

Nature2023

Nat Commun.

2023

ChIP-Seq

Cancer Res.

2023

RNA-Seq

Nat Commun.

2023

eLife

2023

ATAC-Seq

ChIP-Seq

CUT&Tag

H3K27me3,
H3K27ac

H3K9me3

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Badam Enkhmandakh et al. 2023. Single-cell
Transcriptome Landscape of DNA Methylome Regulators
Associated with Orofacial Clefts in the Mouse Dental Pulp.
doi: 10.1177/10556656231172296
Marissa Saenz et al. Longitudinal analysis of a dietary
mouse model of non-alcoholic fatty liver disease(NAFLD) and non-alcoholic steatohepatitis (NASH). doi:
10.1101/2023.05.19.540989
Monika krosel et al. Bromodomain Protein Inhibitors
Reorganize the Chromatin of Synovial Fibroblasts. doi:
10.3390/cells12081149
Christalle Chow et al. ZBTB2 is Recruited to a Specific
Subset of HIF-1 Target Loci to Facilitate Full Gene
Expression Under Hypoxia. doi: 10.1016/j.jmb.2023.168162
Mateus Mota et al. Targeting SWI/SNF ATPases in
H3.3K27M diffuse intrinsic pontine gliomas. 10.1073/
pnas.2221175120
Jose M Ramon-Pittol et al. Dax1 modulates ERα-dependent
hypothalamic estrogen sensing in female mice. doi:
10.1038/s41467-023-38618-y
Mingli Li et al. Epigenetic Control of Translation Checkpoint
and Tumor Progression via RUVBL1-EEF1A1 Axis. doi:
10.1002/advs.202206584
Arijita Subuddhi et al. Comparative transcriptome profile ofmouse macrophages treated with the RhoA/Rock pathway
inhibitors Y27632, Fingolimod (Gilenya), and Rezurock(Belumosudil, SLx-2119). doi: 10.1016/j.intimp.2023.110017
Marion Dejosez et al. Regulatory architecture ofhousekeeping genes is driven by promoter assemblies.
doi: 10.1016/j.celrep.2023.112505
Robbin A Nameki et al. Rewiring of master transcription
factor cistromes during high-grade serous ovarian cancer
development. doi: 10.1101/2023.04.11.536378
Tanner B Jefferson et al. Multiple tissue-specific epigenetic
alterations regulate persistent gene expression changes
following developmental DES exposure in mouse
reproductive tissues.
Hideko Isozaki et al. Therapy-induced APOBEC3A drives
evolution of persistent cancer cells. doi: 10.1038/s41586023-06303-1
Thaddeus J Kunkel et al. The cholesterol transporter NPC1
is essential for epigenetic regulation and maturation ofoligodendrocyte lineage cells. doi: 10.1038/s41467-02339733-6
Dipika R Mohan et al. β-Catenin–Driven Differentiation Is a
Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer.
doi: 10.1158/0008-5472
Daniel Schator et al. Legionella para-effectors target
chromatin and promote bacterial replication. doi: 10.1038/
s41467-023-37885-z
Suhas Sureshchandra et al. Maternal obesity blunts
antimicrobial responses in fetal monocytes. doi: 10.7554/
eLife.81320
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Technique

TargetJournalYear

ChIP-qPCR

RelA, RUNX2

eLife

2023

ChIP-Seq

TEAD1

Cell Rep.

2023

ChIP-Seq

HDAC1, H3K27ac

Nat Commun.

2023

ChIP-Seq

EZH2, H3K27me3

Nat Commun.

2023

CUT&Tag,
RRBS

H3K4me3

Adv Sci.

2023

RIME

Basonuclin 1 (BNC1)

bioRxiv

2023

ATAC-Seq

Nat Commun.

2023

ATAC-Seq

NAR Cancer

2023

ChIP-Seq

H3K27me3

bioRxiv

2023

ChIP-Seq

DUX4Sci Adv.

2023

ChIP-qPCR

H3K9AcCell Rep.

2023

ChIP-Seq

IRF-4

Sci Immunol.

2023

Mod Spec,
RRBS

Cell Rep.

2023

ATAC-Seq

Nat Commun.

2023

Int J Mol Sci.

2022

Cell Rep.

2022

ChIP-Seq

H3K27ac

ATAC-Seq

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Daniel Richard et al. Lineage-specific differences andregulatory networks governing human chondrocyte
development. doi: 10.7554/eLife.79925
Feng Li et al. VGLL4 and MENIN function as TEAD1
corepressors to block pancreatic β cell proliferation. doi:
10.1016/j.celrep.2022.111904
Dasol Han et al. ZBTB12 is a molecular barrier todedifferentiation in human pluripotent stem cells. doi:
10.1038/s41467-023-36178-9
Fan Chen et al. Polycomb deficiency drives a FOXP2-highaggressive state targetable by epigenetic inhibitors. doi:
10.1038/s41467-023-35784-x
David A McBride et al. Immunomodulatory Microparticles
Epigenetically Modulate T Cells and SystemicallyAmeliorate Autoimmune Arthritis. doi: 10.1002/
advs.202202720
Rafik Boudra et al. PRMT1 Inhibition Selectively Targets
BNC1-Dependent Proliferation, but not Migration in
Squamous Cell Carcinoma. doi: 10.1101/2023.03.27.533164
Kuniyuji Aso et al. Itaconate ameliorates autoimmunity bymodulating T cell imbalance via metabolic and epigenetic
reprogramming. doi: 10.1038/s41467-023-36594-x
Anke Koeniger et al. Tumor-suppressive disruption ofcancer subtype-associated super enhancer circuits bysmall molecule treatment. doi: 10.1093/narcan/zcad007
Yingqin Hou et al. Transient EZH2 suppression by
Tazemetostat during in vitro expansion maintains T cellstemness and improves adoptive T cell therapy. doi:
10.1101/2023.02.07.527459
Kaoru Inoue et al. DUX4 double whammy: Thetranscription factor that causes a rare muscular dystrophy
also kills the precursors of the human nose. doi: 10.1126/
sciadv.abq7744
Alison Iroz et al. A Specific ChREBP and PPARα Cross-Talk
Is Required for the Glucose-Mediated FGF21 Response.
doi: 10.1016/j.celrep.2017.09.065
Oriol Fornes et al. A multimorphic mutation in IRF4 causes
human autosomal dominant combined immunodeficiency.
doi: 10.1126/sciimmunol.ade7953
Tetsuya Hirabayashi et al. Hepatic phosphatidylcholine
catabolism driven by PNPLA7 and PNPLA8 supplies
endogenous choline to replenish the methionine cyclewith methyl groups. doi: 10.1016/j.celrep.2022.111940
Bogang Wu et al. RNA polymerase II pausing factor NELF
in CD8+ T cells promotes antitumor immunity. 10.1038/
s41467-022-29869-2
Tomoaki Saito et al. Genome-Wide Super-EnhancerBased Analysis: Identification of Prognostic Genes in Oral
Squamous Cell Carcinoma. Int. J. Mol. Sci. doi: 10.3390/
ijms23169154.
Yayun Gu et al. Multi-omics profiling visualizes dynamics
of cardiac development and functions. doi: 10.1016/j.
celrep.2022.111891
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China (86) 21 20926090

Technique

JournalYear

Cell Rep.

2022

Nucleic Acids Res.

2022

Mol. Ther.

2022

Cells

2022

NPJ Precis Oncol.

2022

scATACSeq

Cell Rep Med.

2022

RNA-Seq,
ATAC-Seq

Inflamm Regen.

2022

ATAC-Seq

Cell Death Differ.

2022

ChIP-Seq

TargetH3K4me1, H3K4me3, H3K27ac,
RNA pol II

ATAC-Seq

ChIP-Seq

H3K4me3, H3K9me3

Hi-C
ChIP-Seq

H3K27ac

ChIP-Seq

p300

Nucleic Acids Res.

2022

ChIP-Seq

KLF4

J. Invest Dermatol.

2022

ChIP-Seq

H3K27ac, H3K27me3, BRG1

Cancer Discov.

2022

RNA-Seq

Nat Metab.

2022

ChIP-Seq

eLife

2022

Nucleic Acids Res.

2022

Nat Commun.

2022

ChIP-Seq

TEAD1

ChIP-qPCR,
ATAC-Seq

H3R2me1,
H3R2me2s

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Yayun Gu et al. Multi-omics profiling visualizes dynamics
of cardiac development and functions. doi: 10.1016/j.
celrep.2022.111891
Sebastian Gregoricchio et al. HDAC1 and PRC2 mediate
combinatorial control in SPI1/PU.1-dependent gene
repression in murine erythroleukaemia. doi: 10.1093/nar/gkac613
Britta Handyside et al. Mol. Ther. Vector genome loss andepigenetic modifications mediate decline in transgene
expression of AAV5 vectors produced in mammalian andinsect cells. doi: 10.1016/j.ymthe.2022.11.001
Sylvia C. Hesitt et al. Progesterone Signaling inEndometrial Epithelial Organoids. doi: 10.3390/cells11111760
Steven W. Criscione et al. The landscape of therapeutic
vulnerabilities in EGFR inhibitor osimertinib drug tolerant
persister cells. doi: 10.1038/s41698-022-00337-w
Yimiing Zhang et al. Pegylated arginine deiminase drives
arginine turnover and systemic autophagy to dictateenergy metabolism. doi: 10.1016/j.xcrm.2021.100498
Sakurako Kobayashi et al. Collagen type I-mediatedmechanotransduction controls epithelial cell fateconversion during intestinal inflammation. doi: 10.1186/
s41232-022-00237-3
Jeehyun Yoon et al. E2F and STAT3 provide transcriptional
synergy for histone variant H2AZ activation to sustain
glioblastoma chromatin accessibility and tumorigenicity.
doi: 10.1038/s41418-021-00926-5
Avital Sarusi Portuguez et al. Ep300 sequestration tofunctionally distinct glucocorticoid receptor binding lociunderlie rapid gene activation and repression. doi: 10.1093/
nar/gkac488
Yao Yuan et al. Oncogenic Hedgehog-Smoothened
Signaling Depends on YAP1-TAZ/TEAD Transcription
to Restrain Differentiation in Basal Cell Carcinoma. doi:
10.1016/j.jid.2021.06.020
Eshini Padnitharatna et al. BAF Complex Maintains Glioma
Stem Cells in Pediatric H3K27M Glioma. doi: 10.1158/21598290.CD-21-1491
Ana P. Gomes et al. Altered propionate metabolism
contributes to tumour progression and aggressiveness.
doi: 10.1038/s42255-022-00553-5
Antigoni Gogolou et al. Early anteroposterior
regionalisation of human neural crest is shaped by a promesodermal factor. doi: 10.7554/eLife.74263
Feng Li et al. TEAD1 regulates cell proliferation through apocket-independent transcription repression mechanism.
doi: 10.1093/nar/gkac1063
Gizem Gunes Gunsel et al. The arginine methyltransferase
PRMT7 promotes extravasation of monocytes resulting intissue injury in COPD. doi: 10.1038/s41467-022-28809-4

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ATAC-Seq

Blood Adv.

2022

ATAC-Seq,
RNA-Seq

Cell Death Differ.

2022

ATAC-Seq

Mucosal Immunol.

2022

ATAC-Seq

Sci Adv.

2022

ATAC-Seq

Front Med
(Lausanne)

2022

RNA-Seq

Mol Oncol.

2022

ChIP-Seq

Androgen Receptor

Oncogene

2022

ChIP-Seq

Estrogen Receptor
alphaEndocrinology

2022

Mol Cancer Ther.

2022

Nat Commun.

2022

ATAC-Seq

ChIP-Seq

H3K36me3

ChIP-Seq

p53, H3K4me3,
H3K9me3

Cells

2022

ChIP-Seq

Progesterone Receptor

Reprod Sci.

2022

Acta Biochim Pol.

2022

ATAC-Seq,
RNA-Seq
ChIP-qPCR

FOXM1Int J Mol Sci.

2022

ChIP-Seq

Estrogen Receptorbeta

J Biomed Sci.

2022

ChIP-Seq

CTCF

Int J Mol Sci.

2022

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Genki Yamato et al. Genome-wide DNA methylation
analysis in pediatric acute myeloid leukemia. doi: 10.1182/
bloodadvances.2021005381.
Kristina Seiler et al. Hexokinase 3 enhances myeloid cell
survival via non-glycolytic functions. doi: 10.1038/s41419022-04891-w.
Soh Yamazaki et al. IκBζ controls IL-17-triggered gene
expression program in intestinal epithelial cells that
restricts colonization of SFB and prevents Th17-associatedpathologies. doi: 10.1038/s41385-022-00554-3.
Jean Personnaz et al. Nuclear HMGB1 protects from
nonalcoholic fatty liver disease through negative
regulation of liver X receptor. doi: 10.1126/sciadv.abg9055.
Jehan Alam et al. IL-17 Producing Lymphocytes Cause
Dry Eye and Corneal Disease With Aging in RXRα Mutant
Mouse. doi: 10.3389/fmed.2022.849990.
Carlotta Zampieri et al. p53 mutations define the chromatin
landscape to confer drug tolerance in pancreatic cancer.
doi: 10.1002/1878-0261.13161.
Oh-Joon Kwon et al. Elevated expression of the colonystimulating factor 1 (CSF1) induces prostatic intraepithelial
neoplasia dependent of epithelial-Gp130. doi: 10.1038/
s41388-021-02169-7.
Sylvia C. Hewitt et al. The Estrogen Receptor α Cistrome
in Human Endometrium and Epithelial Organoids. doi:
10.1210/endocr/bqac116.
Aaron Burmeister et al. Establishment and Evaluation of
Dual HDAC/BET Inhibitors as Therapeutic Options forGerm Cell Tumors and Other Urological Malignancies. doi:
10.1158/1535-7163.MCT-22-0207.
Zhaoyun Ding et al. Setd2 supports GATA3+ST2+ thymicderived Treg cells and suppresses intestinal inflammation.
doi: 10.1038/s41467-022-35250-0.
Takatsune Shimizu et al. Depletion of R270C Mutant p53
in Osteosarcoma Attenuates Cell Growth but Does Not
Prevent Invasion and Metastasis In Vivo. doi: 10.3390/
cells11223614.
Ariel J. Dotts et al. In Vivo Genome-Wide PGR Bindingin Pregnant Human Myometrium Identifies Potential
Regulators of Labor. doi: 10.1007/s43032-022-01002-0.
Pujan Joshi et al. The chromatin accessibility landscapein the dental pulp of mouse molars and incisors. doi:
10.18388/abp.2020_5771.
Erkut Ilaslan et al. Distinct Roles of NANOS1 and NANOS3
in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis toControl G2/M Phase in a Human Primordial Germ Cell
Model. doi: 10.3390/ijms23126592.
Yuri Park et al. Oleuropein suppresses endometriosis
progression and improves the fertility of mice withendometriosis. doi: 10.1186/s12929-022-00883-2.
Clarissa Boschiero et al. Differentially CTCF-Binding Sites
in Cattle Rumen Tissue during Weaning. doi: 10.3390/
ijms23169070.
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

JournalYear

Biomolecules

2022

Autophagy

2022

BiomedPharmacother.

2022

ATAC-Seq

Cancer Immunol
Res.

2022

ATAC-Seq

Cell Rep Med.

2022

Cell Rep.

2022

ChIP-Seq

TargetCTCF

ATAC-Seq,
RNA-Seq

ChIP-Seq

BRD4

ChIP-Seq

RNA Pol II

ChIP-Seq

MAX

Cell Tissue Res.

2022

ChIP-Seq

MAX

Cell Tissue Res.

2022

ChIP-Seq

SMARCA4, H3K27me3

Cells

2022

ATAC-Seq

Commun Biol.

2022

ATAC-Seq

Commun Biol.

2022

ChIP-Seq

H3K27ac

CRISPR J.

2022

ChIP-Seq

H3K27ac

CRISPR J.

2022

EMBO Rep.

2022

FASEB J.

2022

MeDIP-Seq
ChIP-Seq

H3K4me1, H3K4me3

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Clarissa Boschiero et al. Butyrate Induces Modifications of
the CTCF-Binding Landscape in Cattle Cells. doi: 10.3390/
biom12091177.
Eutteum Jeong et al. The FACT complex facilitates
expression of lysosomal and antioxidant genes
through binding to TFEB and TFE3. Autophagy. doi:
10.1080/15548627.2022.2029671.
Laura M. Tsujikawa et al. Breaking boundaries: Pan BETi
disrupt 3D chromatin structure, BD2-selective BETi arestrictly epigenetic transcriptional regulators. Biomed.
Pharmacother. doi: 10.1016/j.biopha.2022.113230.
Andrew Fedoriw et al. Inhibiting Type I arginine
methyltransferase activity promotes the T cell mediatedantitumor immune response. Cancer Immunol. Res. doi:
10.1158/2326-6066.CIR-21-0614.
Sally Mortlock et al. A multi-level investigation of thegenetic relationship between endometriosis andovarian cancer histotypes. Cell Rep Med. doi: 10.1016/j.
xcrm.2022.100542.
Shin-Ichiro Ohno et al. Nuclear microRNAs release paused
Pol II via the DDX21-CDK9 complex. Cell Rep. doi: 10.1016/j.
celrep.2022.110673.
Weixu Ma et al. MAX deficiency impairs humanendometrial decidualization through down-regulating
OSR2 in women with recurrent spontaneous abortio. Cell
Tissue Res. doi: 10.1007/s00441-022-03579-z.
Weixu Ma et al. MAX deficiency impairs humanendometrial decidualization through down-regulating
OSR2 in women with recurrent spontaneous abortion. Cell
Tissue Res. doi: 10.1007/s00441-022-03579-z.
Amelie Alfert et al. Smarcb1 Loss Results in a Deregulationof esBAF Binding and Impacts the Expression of
Neurodevelopmental Genes. Cells. doi: 10.3390/
cells11081354.
Hidenori Machino et al. The metabolic stress-activatedcheckpoint LKB1-MARK3 axis acts as a tumor suppressor inhigh-grade serous ovarian carcinoma. Commun. Biol. doi:
10.1038/s42003-021-02992-4.
Hidenori Machino et al. The metabolic stress-activatedcheckpoint LKB1-MARK3 axis acts as a tumor suppressor inhigh-grade serous ovarian carcinoma. Commun. Biol. doi:
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Antonia A. Dominguez et al. CRISPR-Mediated Synergistic
Epigenetic and Transcriptional Control. CRISPR J. doi:
10.1089/crispr.2021.0099.
Antonia A. Dominuez et al. CRISPR-mediated Synergistic
Epigenetic and Transcriptional Control. CRISPR J. doi:
10.1089/crispr.2021.0099.
Antonia Piazzesi et al. CEST-2.2 overexpression alters
lipid metabolism and extends longevity of mitochondrial
mutants. EMBO Rep. doi: 10.15252/embr.202152606.
Matthew Baxter et al. Circadian clock function does not
require the histone methyltransferase MLL3. FASEB J. doi:
10.1096/fj.202200368R.
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

BRD4, H3K27ac

Front Cell Dev
Biol.

2022

ChIP-Seq

DNMT1

Gastroenterology

2022

ATAC-Seq

Genes (Basel)

2022

ATAC-Seq

Genes (Basel)

2022

ChIP-Seq

CTCF, H3K4me3,
H3K27ac

Genome Res.

2022

ATAC-Seq,
ChIP-Seq

H3K27ac, H3K27me3, H3K4me1,
H3K4me3, CTCF

Genomics

2022

ChIP-Seq

H3K4me3Hepatol Commun.

2022

ChIP-Seq

H3K4me3Hepatol Commun.

2022

ChIP-Seq

H3K4me3Hepatol Commun.

2022

RIME

EOMES

iScience

2022

ChIP-Seq

YAP

J Clin Invest.

2022

ChIP-Seq

H3K9me3

J Immunol.

2022

ChIP-Seq

H3K9me3

J Immunol.

2022

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Cho-Hao Lin et al. AZD5153, a Bivalent BRD4 Inhibitor,
Suppresses Hepatocarcinogenesis by Altering
BRD4 Chromosomal Landscape and Modulating theTranscriptome of HCC Cells. Fron Cell Dev Biol. doi:
10.3389/fcell.2022.853652.
Shikai Hu et al. NOTCH-YAP1/TEAD-DNMT1 Axis
Drives Hepatocyte Reprogramming Into Intrahepatic
Cholangiocarcinoma. Gastroenterology. doi: 10.1053/j.
gastro.2022.05.007.
Clarissa Boschiero et al. Characterization of Accessible
Chromatin Regions in Cattle Rumen Epithelial
Tissue during Weaning. Genes (Basel). doi: 10.3390/
genes13030535.
Clarissa Boschiero et al. Characterization of Accessible
Chromatin Regions in Cattle Rumen Epithelial
Tissue during Weaning. Genes (Basel) doi: 10.3390/
genes13030535.
Blair W. Perry et al. Snake venom gene expression iscoordinated by novel regulatory architecture and theintegration of multiple co-opted vertebrate pathways.
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Yahui Gae et al. Functional annotation of regulatory
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10.1016/j.ygeno.2022.110296
Michael Schonfeld et al. Alcohol-associated fibrosis infemales is mediated by female-specific activation of lysine
demethylases KDM5B and KDM5C. Hepatol. Commun. doi:
10.1002/hep4.1967.
Michael Schonfeld et al. Male-Specific Activation of Lysine
Demethylases 5B and 5C Mediates Alcohol-Induced Liver
Injury and Hepatocyte Dedifferentiation. Hepatol Commun.
doi: 10.1002/hep4.1895.
Michael Schonfeld et al. Male-Specific Activation of Lysine
Demethylases 5B and 5C Mediates Alcohol-Induced
Liver Injury and Hepatocyte Dedifferentiation. Hepatol.
Commun. doi: 10.1002/hep4.1895.
James A. Heslop et al. Chromatin remodeling is restrictedby transient GATA6 binding during iPSC differentiation
to definitive endoderm. iScience. doi: 10.1016/j.
isci.2022.104300.
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Jun Hyung Sin et al. ATF7ip Targets Transposable
Elements for H3K9me3 Deposition to Modify CD8+ T Cell
Effector and Memory Responses. J. Immunol. doi: 10.4049/
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Jun Hyung Sin et al. ATF7ip Targets Transposable
Elements for H3K9me3 Deposition to Modify CD8 + T Cell
Effector and Memory Responses. J. Immunol. doi: 10.4049/
jimmunol.2100996.
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetATAC-Seq

JournalYear

Mol Cancer Res.

2022

ChIP-qPCR

WT1

Mol Oncol.

2022

ChIP-qPCR

H3K27ac, H3K4me2

Nat Commun.

2022

ChIP-Seq

H3K27ac, RNA pol
II, ΔNp63

Nat Commun.

2022

ChIP-qPCR,
Antibody
Validation

H3K27ac, H3K4me2

Nat Commun.

2022

ChIP-qPCR,
Antibody
Validation

KLF5

Sci Adv.

2022

ChIP-Seq

H3K9acTheranostics

2022

ChIP-Seq

H3K27ac, RelA

Acta Neuropathol.

2021

ChIP

H3K27ac, RelA

Acta Neuropathol.

2021

Am J Physiol
Heart Circ Physiol.

2021

Biochem Biophys
Res Commun.

2021

Mod Spec

Blood

2021

ATAC-Seq

Blood

2021

Br J Pharmacol.

2021

Cancer Cell

2021

RNA-Seq

ChIP-Seq

Sp6

ChIP-qPCR

LXRalpha

ChIP-Seq

Multi-Histones

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Aditya Wirawan et al. A Novel Therapeutic Strategy
Targeting the Mesenchymal Phenotype of Malignant
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Alain Chebly et al. Exploring hTERT promoter methylationin cutaneous T-cell lymphomas. Mol Oncol. doi:
10.1002/1878-0261.12946
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Emily V. Dutrow et al. Modeling uniquely human gene
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Juliane Mooz et al. ARAF suppresses ERBB3 expression
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Cancer Cell. doi: 10.1016/j.ccell.2021.01.005.

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

JournalYear

ATAC-Seq

Cancer Discov.

2021

ATAC-Seq,
RNA-Seq

Cancer Immunol
Res.

2021

ATAC-Seq

Cancers (Basel)

2021

Mod Spec

Cancers (Basel)

2021

ATAC-Seq

Cell

2021

Cell Chem. Biol.

2021

Cell Rep.

2021

Cell Rep.

2021

Cells

2021

ChIP-Seq

TargetTDF4

ATAC-Seq

RIME

RelA

RNA-Seq

ChIP-Seq

p300

Clin Transl Med.

2021

ChIP-Seq

FANCD2

Commun Biol.

2021

HistonePTM Analysis

Dev Cell

2021

RNA-Seq

Development

2021

Diabetes

2021

ChIP-Seq

H3K79me2

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Sonia Iyer et al. Genetically Defined Syngeneic Mouse
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Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

JournalYear

PTM Quantitation

eLife

2021

ATAC-Seq

EMBO Rep.

2021

ATAC-Seq

EMBO Rep.

2021

ERJ Open Res.

2021

Int J Mol Sci.

2021

ChIP-Seq

TargetZNF263

ATAC-Seq
ChIP-qPCR

FOXO3

J Cell Physiol.

2021

ChIP-Seq

BRD2, BRD4, RNAPol IIJ Immunol.

2021

J Mol Cell Cardiol.

2021

Mol Cancer Res.

2021

ATAC-Seq

RIME

Estrogen Receptora

ChIP-qPCR

H3K27ac

Mol Cell

2021

ChIP-qPCR

WT1

Mol Oncol.

2021

ChIP-Seq

BRD4, H3K27ac,
H3K4me1

Mol Ther Methods
Clin Dev.

2021

Nat Cancer

2021

ATAC-Seq

ChIP-Seq

BRD4

Nat Chem Biol.

2021

ChIP-Seq

H2AK119Ub, Ring1b

Nat Chem Biol.

2021

North America 877 222 9543

Europe +32 (0)2 653 0001

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and H2A.Z.2 in chromosome segregation and cell cycle
progression. EMBO Rep. doi: 10.15252/embr.202052061.
Raquel Sales-Gil et al. Non-redundant functions of
H2A.Z.1 and H2A.Z.2 in chromosome segregation andcell cycle progression. EMBO Reports. doi: 10.15252/
embr.202052061
Sai Sneha Priya Nemani et al. COL4A3 expressionin asthmatic epithelium depends on intronic
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Vinod Krishna et al. Integration of the Transcriptome andGenome-Wide Landscape of BRD2 and BRD4 Binding
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Douglas J. Chapski et al. Early adaptive chromatin
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Joseph L. Sottnik et al. Mediator of DNA Damage
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Alain Chebly et al. Exploring hTERT promoter methylationin cutaneous T-cell lymphomas. Mol. Oncol. doi:
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Qingwei Wang et al. A hierarchicaal and collaborative
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Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetATAC-Seq
ChIP-Seq

BMAL1

ATAC-Seq
RRBS

ATAC-Seq

ChIP-qPCR

H3K27ac

RRBS

JournalYear

Nat Commun.

2021

Nat Commun.

2021

Nat Commun.

2021

Nucleic Acids Res.

2021

PLoS Pathog.

2021

RNA

2021

Sci Adv.

2021

ChIP-Seq

NR2F2

Sex Dev.

2021

ChIP-Seq

Histone PTMs

Toxicol Sci.

2021

ChIP-Seq

H3K9me3, H3K27me3

Arch Toxicol.

2020

RNA-Seq

Blood Adv.

2020

Mod Spec

Blood Adv.

2020

Cancer Cell

2020

ATAC-Seq

Cancer Discov.

2020

RNA-Seq

Cancers (Basel)

2020

North America 877 222 9543

Europe +32 (0)2 653 0001

ChIP-Seq

H3K27me3

Reference

Joana Esteves de Lima et al. HIRA stabilizes skeletal
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Joana Esteves de Lima et al. HIRA stabilizes skeletal
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Miriam Recalde et al. The splicing regulator SLU7 isrequired to preserve DNMT1 protein stability and DNA
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Naveen Parmar et al. Intestinal-epithelial LSD1 controls
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Ryan L. Setten et al. CRED9: A differentially expressed
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Huairui Yuan et al. SETD2 Restricts Prostate Cancer
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Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetRNA-Seq

JournalYear

Cancers (Basel)

2020

Cardiovasc Ther.

2020

ChIP-qPCR

BRD2, BRD4

RIME

Bcl-6

Cell

2020

ChIP-Seq

CEBP, H3K4me3,
H3K27ac

Cell

2020

ChIP-qPCR

HIF1alpha

Cell Rep.

2020

ChIP-Seq

H3K27ac, AFF4

Commun Biol.

2020

Diabetes

2020

ATAC-Seq

Reference

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Sylwia Wasiak et al. Epigenetic Modulation by Apabetalone
Counters Cytokine-Driven Acute Phase Response In
Vitro, in Mice and in Patients with Cardiovascular Disease.
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Leandro Venturutti et al. TBL1XR1 Mutations Drive
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Louise Ménégaut et al. Interplay between Liver X Receptorand Hypoxia Inducible Factor 1a Potentiates Interleukin1b Production in Human Macrophages. Cell Reports. doi:
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Robyn T. Sussman et al. CAMKV Is a Candiate
Immunotherapeutic Target in MYCN Amplified
Neroblastoma. Front. Oncol. 2020 doi: 10.3389/
fonc.2020.00302

ChIP-Seq

HOXB13, H3K27ac,
H3K27me3, H3K4me3, RNA Pol II

Exp Cell Res.

2020

ChIP-Seqb-catenin

Exp Mol Med.

2020

ChIP-Seq

Estrogen Receptor

FASEB J.

2020

ChIP-Seq

N-MYC, C-MYC

Front Oncol.

2020

ChIP-Seq

H3K4me1, H3K4me3, H3K9me3,
H3K27me3,
H3K27ac, H3K36me3, BRD4,
MED1, MYC

Haematologica"Aneta Mikulasova et al. Microhomology-mediatedend joining drives complex rearrangements and over2020 expression of MYC and PVT1 in
multiple myeloma. Haematologica.doi:10.3324/
haematol.2019.217927"

RNA-Seq

iScience

Hi-C

ChIP-Seq

J Biol Chem.

HA-tagged AHR1

North America 877 222 9543

mBio.

Aarti Mishra et al. Dynamic Neuroimmune Profile during2020 Mid-life Aging in the Female Brain and Implications for
Alzheimer Risk. iScience. doi: 10.1016/j.isci.2020.101829.
Sylvia Hewitt et al. Estrogen receptor α (ERα)-binding
super enhancers drive key mediators that control uterine
2020
estrogen responses in mice. JBC. 2020 doi: 10.1074/jbc.
RA120.013666
Sofia Ruben et al. Ahr1 and Tup1 Contribute to the2020 Transcriptional Control of Virulence-Associated Genes in
Candida albicans. mBio. 2020 doi: 10.1128/mBio.00206-20

Europe +32 (0)2 653 0001

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-qPCR

BRG1, MITF

Mol Cancer Ther.

2020

ChIP-Seq

H3K27ac

Mol Neurobiol.

2020

ChIP-Seq

IRF-2

Nat Cell Biol.

2020

Nat Commun.

2020

ChIP-Seq

Reference

Florencia Rago et al. The Discovery of SWI/SNF
Chromatin Remodeling Activity as a Novel and Targetable
Dependency in Uveal Melanoma. Mol. Cancer Ther. doi:
10.1158/1535-7163
Sunil Bhattarai et al. Modulation of Brain Pathology by
Enhancer RNAs in Cerebral Ischemia. Mol. Neurobiol. Mol.
Neurobiol. doi: 10.1007/s12035-020-02194-9
Taku Sato et al. Regulated IFN signalling preserves
the stemness of intestinal stem cells by restricting
differentiation into secretory-cell lineages. Nat. Cell Biol.
doi: 10.1038/s41556-020-0545-5.
Gulfem D. Guler et al. Detection of early stage pancreaticcancer using 5-hydroxymethylcytosine signatures incirculating cell free DNA. Nat. Commun. doi: 10.1038/
s41467-020-18965-w.
Tharu M. Fernando et al. Functional characterizationof SMARCA4 variants identified by targeted exomesequencing of 131,668 cancer patients. Nat. Commun. doi:
10.1038/s41467-020-19402-8.

ChIP-Seq

SMARCA2, SMARCA4Nat Commun.

2020

ChIP-Seq

H3K27ac, H3K27me3, H3K3me1,
H3K9me3, H3K36me3

Nat Commun.

Yonghe Wu et al. Glioblastoma epigenome profiling2020 identifies SOX10 as a master regulator of molecular tumour
subtype. Nat. Commun. doi: 10.1038/s41467-020-20225-w.

ChIP-Seq

N-MYC, BRD4,
H3K9me3, RNAPol IINat Commun.

2020

Nat Genet.

2020

Nat Metab.

2020

RNA-Seq

Nature2020

ATAC-Seq

Nature2020

ATAC-Seq
ChIP-Seq

FLAG-tagged
MRG15

ChIP-Seq

N-MYC, H3K27ac

Neoplasia

2020

ChIP-Seq

RNA Pol II

PLoS Genet.

2020

ATAC-Seq

Proc Natl Acad
Sci USA

2020

North America 877 222 9543

Europe +32 (0)2 653 0001

"Maged Zeineldin et al. MYCN amplification and ATRX
mutations areincompatible in neuroblastoma. Nat. Commun.doi: 10.1038/
s41467-020-14682-6"
Mark M. Pomerantz et al. Prostate cancer reactivates
developmental epigenomic programs during metastatic
progression. Nat. Genet. doi: 10.1038/s41588-020-0664-8.
Yuda Wei et al. MRG15 orchestrates rhythmic epigenomic
remodelling and controls hepatic lipid metabolism. Nat
Metab. 2020 doi: 10.1038/s42255-020-0203-z
Ana P. Gomes et al. Age-induced accumulation of
methylmalonic acid promotes tumour progression. Nature.
doi: 10.1038/s41586-020-2630-0.
"Biraj Mahato et al. Pharmacologic fibroblast
reprogramming
into photoreceptors restores vision. Nature. 2020 doi:
10.1038/s41586-020-2201-4"
Dongdong Chen et al. LIN28B promotes neuroblastoma
metastasis and regulates PDZ binding kinase. Neoplasia.
2020 doi: 10.1016/j.neo.2020.04.001
Katherine I. Farley-Barnes et al. Paired Box 9 (PAX9), theRNA polymerase II transcription factor, regulates humanribosome biogenesis and craniofacial development. PLoS
Genet. doi: 10.1371/journal.pgen.1008967.
Kruttika Bhat et al. The dopamine receptor antagonist
trifluoperazine prevents phenotype conversion andimproves survival in mouse models of glioblastoma. PNAS.
2020 doi: 10.1073/pnas.1920154117

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

Sci Data

Kristen Upton et al. Epigenomic profiling of2020 neuroblastoma cell lines. Sci Data. 2020 doi: 10.6084/
m9.figshare.11993883

ATAC-Seq,
ChIP-Seq

N-MYC, C-MYC,
H3K4me1, H3K4me3, H3K27ac,
H3K27me3

RIME

Estrogen Receptora

Sci Signal.

ChIP-Seq

Progesterone Receptor

Sci Signal.

ChIP-Seq

H3K4me3, H3K9me3, H3K27me3,
H3R8me2a,H4K20me3

Theranostics

ChIP-Seq

H3K27ac

Transl Oncol.

ChIP-Seq

H3K27me3,
H3K4me3

Acta Neuropathol.

ChIP-Seq

RNA Pol II

Agronomy

ChIP-Seq

H3K4me1, H3K4me3, H3K27ac,
H3K27me3

ATAC-Seq

Yin Li et al. A mutant form of ERα associated with estrogen
insensitivity affects the coupling between ligand binding2020
and coactivator recruitment. Sci. Signal. doi: 10.1126/
scisignal.aaw4653.
Margeaux Wetendorf et al. Constitutive expressionof progesterone receptor isoforms promotes the2020
development of hormone-dependent ovarian neoplasms.
Sci. Signal. doi: 10.1126/scisignal.aaz9646.
Qian Zhang et al. Mdig promotes oncogenic gene2020 expression through antagonizing repressive histone
methylation markers. Theranostics 2020; 10(2):602-614.
Jie Cui et al. A zinc finger family protein, ZNF263,
promotes hepatocellular carcinoma resistance to apoptosis
2020
via activation of ER stress-dependent autophagy. Transl.
Oncol. 10.1016/j.tranon.2020.100851.
Andre Silveira et al. H3.3 K27M depletion increases
2019 diferentiation and extends latency of diffuse intrinsic
pontine glioma growth in vivo. Acta Neuropathol. 137: 1021
2019

BMC Biol.

2019

Cancer Cell

2019

Cancer Cell

2019

ChIP-Seq

H3K27me3

ChIP-Seq

H3K27me3,
H3K4me1, H3K4me3, H3K9me3,
H3K36me3,
EZH2, SMARCB1,
SUZ12,SMARCA4,REST

Cancer Cell

2019

ChIP-Seq

H3K27acCancer Res.

2019

ChIP-Seq

Estrogen Receptor

Cell

2019

ChIP-Seq

H4 panAc

Cell Metab.

2019

North America 877 222 9543

Reference

Europe +32 (0)2 653 0001

Sonja Klemme et al. Selection of Salicylic Acid Tolerant
Epilines in Brassica napus. Agronomy. 9: 92
Lingzhao Fang et al. Functional annotation of the cattle
genome through systematic discovery and characterizationof chromatin states and butyrate-induced variations. BMC
Biol. 17: 68
Ana P. Gomes et al. Dynamic incorporation of histone
H3 variants into chromatin is essential for acquisition of
aggressive traits and metastatic colonization. Cancer Cell.
36: 402
Zulekha A. Qadeer et al. ATRX in-frame fusion
neuroblastoma is sensitive to EZH2 inhibition via
modulation of neuronal gene signatures. Cancer Cell. 36:
512
Serap Erkek et al. Comprehensive Analysis of ChromatinStates in Atypical Teratoid/Rhabdoid Tumors Identified
Diverging Roles for SWI/SNF and Polycomb in Gene
Regulation. Cancer Cell. 35: 95
Joesph Castillo et al. CBP/p300 drives the differentiationof Regulatory T cells through transcriptional and nontranscriptional mechanisms. Cancer Res. 79: 3916
"Jane Guan et al. Therapeutic ligands antagonize estrogen
receptorfunction by impairing its mobility. Cell. 178: 15"
Ramon C. Sun et al. Nuclear glycogenolysis modulates
histone acetylation in human non-small cell lung cancers.
Cell Metab. 30: 1
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

JournalYear

Cell Metab.

2019

Cell Rep.

2019

Cell Rep.

2019

ChIP-Seq,
RNA-Seq
ASH2L, H3K4me3
Data Analysis

Cell Rep.

2019

ChIP-Seq,
ChIP-qPCR

CBP, p300,
H3K27ac

Cell Rep.

2019

ChIP-Seq

RNA Pol II

Cell Stem Cell

2019

ChIP-qPCR

BRD4, RelA

Clin Epigenetics

2019

EMBO J.

2019

Epigenomes

2019

Haematologica

2019

ChIP-Seq

TargetH3K4me1, H3K4me3, H3K27ac

Mod Spec

ChIP-Seq,
ChIP-qPCR

Androgen Receptor, Estrogen
Receptor

RNA-Seq

MeDIP-Seq

5-Methylcytosine

ATAC-Seq

ChIP-Seq,
Spike-in

H3K27me3

Haematologica

2019

ChIP-qPCR

PPARg

Int J Obes (Lond).

2019

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference"Liming Du et al. IGF-2 Preprograms Maturing
Macrophages to
Acquire Oxidative Phosphorylation-Dependent
Antiinflammatory
Properties. Cell Metab. 29: 1""Banushree Kumar et al. Quantitative Multiplexed ChIP
Reveals Global
Alterations that Shape Promoter Bivalency in Ground State
Embryonic Stem Cells. Cell Reports. 28: 3274–3284.""Karyn Schmidt et al. The lncRNA SLNCR Recruits theAndrogen Receptor
to EGR1-Bound Genes in Melanoma and Inhibits
Expression of Tumor Suppressor p21. Cell Reports. 27:
2493""Liang Li et al. The COMPASS Family Protein ASH2L
Mediates
Corticogenesis via Transcriptional Regulation of Wnt
Signaling. Cell Reports. 28: 698"
Denise de Almeida Nagata et al. Regulation of TumorAssociated Myeloid Cell Activity by CBP/EP300
Bromodomain Modulation of H3K27 Acetylation. Cell
Reports. 27:269
Kimberley N. Babos et al. Mitigating antagonism between
transcription and proliferation allows near-deterministic
cellular reprogramming. Cell Stem Cell. 25: 486"Laura Tsujikawa et al. Apabetalone (RVX-208) reduces
vascular
inflammation in vitro and in CVD patients by a BETdependent epigenetic mechanism. Clin Epigenet. 11: 102"
"Kathryn A. Jacobs et al. Paracaspase MALT1 regulates
glioma cell survival
by controlling endo-lysosome homeostasis. EMBO J. doi:
10.15252/embj.2019102030"
Liliana Ferreira et al. Uncovering Differentially Methylated
Regions (DMRs) in a Salt-Tolerant Rice Variety underStress: One Step towards New Regulatory Regions forEnhanced Salt Tolerance. Epigenomes. 3:4
James Ropa et al. SETDB1 mediated histone H3 lysine 9
methylation suppresses MLL-fusion target expression andleukemic transformation. Haematologica. doi: 10.3324/
haematol.2019.223883"Shao Xie et al. EZH2 inhibitors abrogate upregulation oftrimethylationof H3K27 by CDK9 inhibitors and potentiate its activity
against diffuse large B-cell lymphoma. Haematologica.
doi:10.3324/haematol.2019.222935""Laura Butruille et al. Maternal high-fat diet during suckling
programs visceral adiposity and epigenetic regulation of
adipose tissue stearoyl-CoA
desaturase-1 in offspring. Int J Obes (London) doi: 10.1038/
s41366-018-0310-z"

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

H3K27me3,
H3K27ac, H3K4me3

Invest Ophthalmol
Vis Sci.

2019

ChIP-Seq,
RNA-Seq

Glucocorticoid
Receptor

J Am Heart Assoc.

2019

ChIP-Seq

H4K20me1

J Autoimmun.

2019

ChIP-Seq

SMC1a, H3K4me1, H3K4me3,
H3K27ac

J Biol Chem.

2019

ChIP-Seq,
ChIP-qPCR

Progesterone Receptor

J Clin Endocrinol
Metab.

2019

ChIP-Seq

BRG1

J Clin Invest.

2019

ChIP-Seq

H3K9me3

J Exp Med.

2019

ChIP-Seq

Androgen Receptor J Mol Med (Berl).

2019

ChIP-Seq

RNA Pol II,
H3K27ac

J Neurooncol.

2019

ChIP-Seq

EGR1, H3K27ac

J Steroid Biochem
Mol Biol.

2019

ChIP-Seq,
RNA-Seq

H3K4me3, H3K27me3

JCI Insight

2019

ChIP-Seq,
ChIP-qPCR

Androgen Receptor

Mol Cell
Endocrinol.

2019

ChIP-Seq

YAP1, NFIANat Commun.

2019

ChIP-Seq

BRG1, H3K9Ac

Nat Commun.

2019

ChIP-Seq

BRD4

Nat Commun.

2019

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference"Christina F. Tingle et al. Paradoxical Changes Underscore
Epigenetic
Reprogramming During Adult Zebrafish Extraocular
Muscle Regeneration. Invest Ophthalmol Vis Sci.
2019;60:4991–4999"
Elena Severinova et al. Glucocorticoid Receptor‐Binding
and Transcriptome Signature in Cardiomyocytes. J Am
Heart Assoc. 8: e011484.
Keqi Fan et al. CRL4DCAF2is required for mature T-cell
expansion via Aurora B-regulatedproteasome activity. J of
Autoimmun. 96:74
Sylvia C. Hewitt et al. A distal super enhancer mediates
estrogen-dependent mouse uterine–specific genetranscription of Igf1 (Insulin-like growth factor 1). J Biol
Chem. 294: 9746
Ru-pin Alicia Chi et al. Human endometrial transcriptome
and progesterone receptor cistrome reveal important
pathways and epithelial regulators. J Clin Endocrhinol
Metab. doi: 10.1210/clinem/dgz117
Yufeng Ding et al. Chromatin remodeling ATPase BRG1
and PTEN are synthetic lethal in prostate cancer. J Clin
Invest. 129: 759"Jun Hyung Sin et al. The epigenetic regulator ATF7ip
inhibits Il2
expression, regulating Th17 responses. J. Exp Med . 216:
2024"
Kinza Younas et al. Delated endometrial decidualisation inpolycystic ovary syndrome; the role of AR-MAGEA11. J Mol
Med 2019 doi: 10.1007/s00109-019-01809-6
Isabel Tegeder et al. Functional relevance of genes
predicted to be affected by epigenetic alterations inatypical teratoid/rhabdoid tumors. J. Neurooncol. 141: 43"Maria Szwarc et al. Early growth response 1
transcriptionally primes thehuman endometrial stromal cell for decidualization. J
Steroid Biochem. 189: 283"
Taiyi Huo et al. Induction of α cell-restricted Gc in
dedifferentiating β cells contributes to stress-induced
β-cell dysfunction. J Clin Invest. 5: 128351
Claire Nash et al. Genome-wide analysis of AR binding andcomparison with transcript expression in primary human
fetal prostate fibroblasts and cancer associated fibroblasts.
Mol Cell Endocrinol. 471: 1
Kristian W. Pajtler et al. YAP1 subgroup supratentorial
ependymoma requires TEAD and nuclear factor I-mediatedtranscriptional programmes for tumorigenesis. Nat
Commun. 10: 3914
Min Liu et al. BRG1 attenuates colonic inflammation andtumorigenesis through autophagy-dependent oxidative
stress sequestration. Nat Commun. 10: 4614
"Nicolas Mercado et al. IRF2 is a master regulator ofhuman keratinocyte
stem cell fate. Nat Commun. 10: 4676"
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

RUNX1

Nat Commun.

2019

ChIP-Seq

H3K27acNat Commun.

2019

ChIP-Seq

H3K27acNat Commun.

2019

ChIP-Seq

SALL3, DNMT3B

Nat Commun.

2019

ChIP-qPCR

SRF, CEBPNat Commun.

2019

ChIP-Seq

H3K27ac, H3K4me3,
CTCF, NR4A3Nat Commun.

2019

ChIP-Seq

GFI1, LSD1Nat Commun.

2019

Mod Spec

Nat Genet.

2019

ChIP-qPCRNRF2Nat Immunol.

2019

ChIP-qPCRChREBP

Nat Metab.

2019

ATAC-Seq,
ChIP-Seq

H3K4me3, H3K27ac,
H3K27me3

Nature2019

ChIP-Seq

BRD4, H3K9me3

Neuron2019

RIME

PPARb/dNucleic Acids Res.

2019

Plant Biotechnol
J.

2019

Next-Gen
BisulfiteSeq
ChIP-Seq

Progesterone Receptor, H3K27ac

Sci Rep.

2019

ChIP-Seq

LSD1, H3K4me2,
H3K27acSci Signal.

2019

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Barbara Nicol et al. RUNX1 maintains the identity of the
fetal ovary through an interplay with FOXL2. Nat. Commun.
10: 5116
Jayaram Vijayakrishnan et al. Identification of four novelassociations for B-cell acute lymphoblastic leukaemia risk.
Nat Commun. 10: 5348
"Liqing Tian et al. Long-read sequencing unveils IGH-DUX4translocation into the silenced IGH allele in B-cell acutelymphoblastic leukemia. Nat. Commun. 10: 2789""Takuya Kuroda et al. SALL3 expression balance underlies
lineage biases
in human induced pluripotent stem cell differentiation. Nat
Commun. 10: 2175""S. Sarcar et al. Next-generation muscle-directed genetherapy byin silico vector design. Nat Commun. 10: 492"
Florian Haller et al. Enhancer hijacking activatesoncogenic transcription factor NR4A3 in acinic cell
carcinomas of the salivary glands. Nat Commun. 10: 336
Catherine Lee et al. Lsd1 as a therapeutic target in Gfi1activated medulloblastoma. Nat Commun. 10: 332"Sara Martire et al. Phosphorylation of histone H3.3 atserine 31
promotes p300 activity and enhancer acetylation. Nat.
Genet. 51: 941"
Anne-Valerie Burgener et al. SDHA gain-of-function
engages inflammatory mitochondrial retrograde signaling
via KEAP1–Nrf2. Nat Immunol. 20: 1311
"Pauline Morigny et al. Interaction between hormonesensitive lipase and
ChREBP in fat cells controls insulin sensitivity. Nat. Metab.
1: 133"
Nina Oberbeck et al. The RIPK4–IRF6 signalling axis
safeguards epidermal differentiation and barrier function.
Nature. 574: 249
Jackie L. Norrie et al. Nucleome dynamics during retinal
development. Neuron. 104:1
Nathalie Legrand et al. PPARb/d recruits NCOR andregulates transcription reinitiation of ANGPTL4. Nucleic
Acids Res. 47: 9573
"Aurine Verkest et al. Impact of differential DNA
methylation on transgene
expression in cotton (Gossypium hirsutum L.) events
generated by targeted sequence insertion. Plant
Biotechnol. J. 17: 1236"
Diem T. Dinh et al. Tissue-specific progesterone receptorchromatin binding and the regulation of progesteronedependent gene expression. Sci Rep. 19: 9
Arnaud Augert et al. Targeting NOTCH activation in small
cell lung cancer through LSD1 inhibition. Sci.Signal. 12:
eaau2922
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique
ChIP-Seq

TargetH3K27me3

Mod Spec

JournalYear

Acta Neuropathol
Commun.

2018

Acta Neuropathol.

2018

Agronomy

2018

Am J Hum Genet.

2018

Arthritis
Rheumatol.

2018

ChIP-Seq,
Next-Gen
BisulfiteSeq

H3K4me3, RNA Pol II

ChIP-Seq

GATA2

ChIP-qPCR

Glucocorticoid Receptor, TIF1

ChIP-Seq

BRD4

Atherosclerosis

2018

ChIP-Seq

RNA Pol II, H2A.Z,
CDK9, ANP32e

Biochim Biophys
Acta Gene Regul
Mech.

2018

ChIP-Seq

BRD4

Blood

2018

ChIP-Seq

BRD4, RNA Pol II

Cancer Cell

2018

ChIP-Seq

HDAC2, H3K27ac,
H3K27me3

Cancer Immunol
Immunother.

2018

ChIP-Seq

MTA1

Cancer Med.

2018

Ceell Commun
Signal.

2018

RNA-Seq
ChIP-Seq

H3K27ac

Cell

2018

ChIP-Seq

H3K36me2

Cell Rep.

2018

North America 877 222 9543

Europe +32 (0)2 653 0001

ReferenceDavid Castel et al. Transcriptomic and epigenetic profilingof ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate
two subgroups based on the type of histone H3 mutatedand not supratentorial or infratentorial location. Acta
Neuropathol Commun. 6: 17
Leah Katz et al. Loss of histone H3K27me3 identifies a
subset of meningiomas with increased risk of recurrenceActa Neuropathl. 135:955"Martin Schmidt et al. Methylome and epialleles in riceepilines selected
for energy use efficiency. Agronomy. 8: 163"
Katelyn M. Mika et al. An ancientfecundability-associatedpolymorphism creates a GATA2 binding site in a distalenhancer of HLA-F. Am J Hum Genet. 103: 509
Yanhua Hu et al. Development of a molecular signature tomonitor pharmacodynamic response mediated by in vivo
administration of glucocorticoids. Arthritis Rheumatol. 70:
1331
Dean Gilham et al. Apabetalone downregulates factors
and pathways associated with vascular calcification
Atherosclerosis 280:75
Hyewon Shin et al. Transcriptional regulation mediatedby H2A.Z via ANP32e-dependent inhibition of protein
phosphatase 2A. Biochim Biophys Acta. 1861: 481
Rebecca Kohnken et al. Diminished microRNA-29b level isassociated with BRD4 mediated activation of oncogenes
in cutaneous T-cell lymphoma. Blood. 131: 771
Elizabeth Stewart et al. Identification of therapeutictargets in rhabdomyosarcoma through integrated
genomic, epigenomic, and proteomic analyses. Cancer
Cell. 34: 1
David Briere et al. The class I/IV HDAC inhibitor
mocetinostat increases tumor antigen presentation,
decreases immune suppressive cell types andaugments checkpoint inhibitor therapy. Cancer Immunol
Immunother. 67: 381
Nasir A. Butt et al. Targeting MTA1/HIF-1α signaling bypterostilbene in combination with histone deacetylase
inhibitor attenuates prostate cancer progression. Cancer
Med. 6: 2673
Keri Callegari et al. Pharmacological inhibition of LSD1
activity blocks REST-dependent medulloblastoma cell
migration. Cell Commun Signal. 16: 60
Xun Huang et al. Targeting epigenetic crosstalk as atherapeutic strategy for EZH2-aberrant solid tumors. Cell.
175: 1"Jingjing Chen et al. Methyltransferase Nsd2 Ensures
Germinal Center
Selection by Promoting Adhesive Interactions between B
Cells and Follicular Dendritic Cells Cell Reports. 25: 3393"

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique
ChIP-Seq

TargetRNA Pol II, BRD4,
H3K9me3

ATAC-Seq

JournalYear

Cell Rep.

2018

Cell Rep.

2018

RIME

TRPS1

Cell Rep.

2018

ChIP-Seq,
RIME

p300, CBP, CDK9,
BRD4, H3K27ac,
H3K4me1, H3K4me3,
H3K18Ac

Cell Rep.

2018

ChIP-Seq

ZFP24

Cell Rep.

2018

ChIP-Seq,
HistonePTM Quantitation

H3K9me3, H3K27me3

Cell Rep.

2018

ChIP-Seq

H3K27ac

Clin Cancer Res.

2018

ChIP-Seq

H3K27me3

G3 (Bethesda)

2018

ChIP-qPCR

p65, RelA

Hum Mol Genet.

2018

ChIP-Seq

FOXL2

Hum Mol Genet.

2018

ChIP-Seq

NRF2

J Biol Chem.

2018

ChIP-Seq,
ChIP-qPCR

TRRAP

J Cell Biol.

2018

ChIP-Seq,
RNA-Seq

H3K27ac, MED1, RNAPol IIJ Clin Invest.

2018

ChIP-Seq

EZH2

J Exp Med.

2018

ChIP-Seq

ELL2

J Immunol.

2018

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Lu Wang et al. Retinal Cell Type DNA Methylation andHistone Modifications Predict Reprogramming Efficiency
and Retinogenesis in 3D Organoid Cultures. Cell Reports.
22: 2601
Xiaolong Zhang et al. OX40 Costimulation inhibits Foxp3
expression and Treg induction via BATF3-dependent andindependent mechanisms. Cell Reports. 24: 607
Robert M. Witwicki et al. TRPS1 Is a lineage-specifictranscriptional dependency in breast cancer. Cell Reports.
25: 1255
Ryan Raisner et al. Enhancer activity requires CBP/P300
bromodomain-dependent histone H3K27 acetylation. Cell
Reports. 24: 1722
Benayahu Elbaz et al. Phosphorylation state of ZFP24
controls oligodendrocyte differentiation. Cell Reports. 23:
2254
Jessica Camacho et al. The memory of environmental
chemical exposure in C. elegans is dependent on thejumonji demethylases jmjd-2 and jmjd-3/utx-1. Cell
Reports. 23: 2392
Shori Saito et al. Eradication of central nervous system
leukemia of T-cell origin with a brain-permeable LSD1
inhibitor Clin Cancer Res. 25:1601
James Ferguson et al. PRC2 is dispensable in vivo forb-catenin-mediated repression of chondrogenesis in themouse embryonic cranial mesenchyme. G3. 8: 491
Jeffrey R. Gehlhausen et al. A proteasome-resistantfragment of NIK mediates oncogenic NF-κB signaling in
schwannomas. Hum Mol Gen. 28:572"Barbara Nicol et al. Genome-wide identifcation of FOXL2
binding andcharacterization of FOXL2 feminizing action in the fetal
gonads. Hum Mol Genet. Advance online publication doi:
10.1093/hmg/ddy312""Junsheng Fu et al. Hyperactivity of the transcription
factor Nrf2 causes
metabolic reprogramming in mouse esophagus. J. Biol.
Chem. 294: 327."
Zhao Wang et al. TRRAP is a central regulator of humanmulticiliated cell formation. J Cell Biol. 217: 1941
Maria Florencia Martinez et al. Super-Enhancers maintainrenin-expressing cell identity and memory to preserve
multi-systemhomeostasis. J. Clin Invest. Advance online
publication doi: 10.1172/JCI121361
Xingli Zhang et al. Macrophage/microglial Ezh2 facilitates
autoimmune inflammation through inhibition of Socs3. J
Exp Med. 215: 1365
Ashley M. Nelson et al. RNA splicing in the transition from
B cells to antibody-secreting cells: The influences of ELL2,
small nuclear RNA, and endoplasmic reticulum stress. J
Immunol. doi: 10.4049/jimmunol.1800557
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

Reference

J Neuroimmune
Pharmacol.

2018

Nikki Bortell et al. Sirtuin 1-chromatin-binding dynamics
points to a common mechanism regulating inflammatory
targets in SIV infection and in the aging brain. J
Neuroimmune Pharmacol. 13: 163

JCI Insight

2018

ChIP-Seq

SIRT1

ChIP-Seq

BRD4, H3K27ac

ChIP-Seq

FOXG1

Mol Neurobiol.

2018

ChIP-Seq

MTA1

Mol Oncol.

2018

ChIP-Seq

NRF2

Mol Pharmacol.

2018

ChIP-Seq

SOX17

Nat Commun.

2018

ChIP-Seq,
RNA-Seq

NRF2, RNA Pol II

Nat Commun.

2018

ChIP-Seq

TET1, DNMT1Nat Genet.

2018

Pain

2018

RNA-Seq

ATAC-Seq,
ChIP-Seq

H3K36me3, H3K27ac

PLoS One2018

ChIP-Seq

BHLHE40

PLoS One2018

ChIP-Seq

RNA Pol II

PLoS One2018

ChIP-Seq

H3K4me3, H3K9me3,
H3K27me3

Proc Biol Sci.

2018

ChIP-Seq

CREB, SWc

Sci Rep.

2018

MeDIP-Seq

5-Methylcytosine

Sci Rep.

2018

North America 877 222 9543

Europe +32 (0)2 653 0001

Anisley Valenciaga et al. Transcriptional targeting of
oncogene addiction in medullary thyroid cancer. JCIInsight. 3: e122225
Stefan Weise et al. FOXG1 Regulates PRKAR2B
Transcriptionally and Posttranscriptionally via miR200 in
the Adult Hippocampus. Mol. Neurobio. S12035-018-1444.
Avinash Kumar et al. MTA drives malignant progression
and bone metatasis in prostate cancer. Mol. Oncol.
12:1596
Rance Nault et al. Comparison of hepatic NRF2 and AHR
binding in 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD)
treated mice demonstrates NRF2- independent PKM2
induction. Mol Pharmacol. 94: 876
Xiaoqiu Wang et al. SOX17 regulates uterine epithelial–
stromal cross- talk acting via a distal enhancer upstreamof Ihh. Nat Commun. 9: 4421
David Olagnier et al. Nrf2 negatively regulates STING
indicating a link between antiviral sensing and metabolic
reprogramming. Nat Commun. 9: 3506
Nipun Verma et al. TET proteins safeguard bivalentpromoters from de novo methylation in human embryonicstem cells. Nat Genet. 50: 83
Pradipta Ray et al. Comparative transcriptome profilingof the human and mouse dorsal root ganglia: an RNASeq based resource for pain and sensory neuroscience
research Pain. 159:1325"Ryan K. Shultzaberger et al. Agnostic detection of
genomic alterations byholistic DNA structural interrogation. PLoS ONE 13(11):e02080554"
Kelly A. Hamilton et al. Mice lacking the transcriptional
regulator Bhlhe40 have enhanced neuronal excitability
and impaired synaptic plasticity in the hippocampus. PLoS
One. 13: e0196223
Liana Basova et al. Dopamine and its receptors playa role in the modulation of CCR5 expression in innate
immune cells following exposure to Methamphetamine:
Implications to HIV infection. PLoS One. 13: e0199861
Theresa K. Kelly et al. Epigenetic regulation oftranscriptional plasticity associated with developmental
song learning. Proc Biol Sci. 285: 20180160
Jason L. Larabee et al. Unique, Intersecting, andOverlapping Roles of C/EBP β and CREB in Cells of the
Innate Immune System Sci Rep. 8:16931
Jose P. silva et al. Analysis of diet-induced differential
methylation, expression, and interactions of lncRNA andprotein- coding genes in mouse liver. Sci Rep. 8: 11537

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

STAT3, STAT5,
ROCK2

Sci Rep.

2018

ChIP-Seq

HA-tagged JP2NT,
TBP, MEF2C

Science2018

ChIP-Seq

G34R

Acta Neuropathol
Commun.

2017

ChIP-Seq

Progesterone Receptor

Biol Reprod.

2017

ATAC-Seq,
ChIP-Seq

H3K4me3, H3K9me3

Cancer Cell

2017

ChIP-Seq,
ChIP-qPCR

EZH2, H3K27me3,
H3K27acCancer Cell

2017

RIME

Estrogen Receptor, Progesterone
Receptor

Cancer Res.

2017

ChIP-Seq,
Spike-in

p300, H3K27ac,
Androgen Receptor

Cancer Res.

2017

ChIP-Seq

SLY1

Cell Death Differ.

2017

ChIP-qPCR

H3K9Ac, RNA Pol II,
ChREBP, PPARαCell Rep.

2017

ChIP-Seq

TRIM28Cell Rep.

2017

MeDIP-Seq

5-Methylcytosine

Cereb Cortex

2017

ChIP-Seq

LMX1b

Development

2017

ChIP-Seq,
ChIP-qPCR

Estrogen Receptor

Endocrinology

2017

ChIP-Seq

Estrogen Receptor

Endocrinology

2017

ChIP-Seq

H3K27ac, H3K4me1

Epigenomics

2017

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Wei Chen et al. ROCK2, but not ROCK1 interacts withphosphorylated STAT3 and co-occupies TH17/TFH genepromoters in TH17-activated human T cells. Sci Rep. 8:
16636
Ang Guo et al. E-C coupling structural proteinjunctophilin-2 encodes a stress-adaptive transcription
regulator. Science. 362:6421.
Farhana Haque et al. Evaluation of a novel antibody todefine histone 3.3 G34R mutant brain tumours. Acta
Neuropathol Commun. 5: 45
Margeaux Wetendorf et al. Decreased epithelial
progesterone receptor A at the window of receptivity isrequired for preparation of the endometrium for embryo
attachment. Biol Reprod. 96: 313.
Gulfem Dilek Guler et al. Repression of stress-induced
LINE-1 expression protects cancer cell subpopulations
from lethal drug exposure. Cancer Cell. 32: 1
Eric E. Gardner et al. Chemosensitive relapse in small
cell lung cancer proceeds through an EZH2-SLFN11 axis.
Cancer Cell. 31: 286"Jessica Finlay-Schultz et al. Breast cancer suppression byprogesterone
receptors is mediated by their modulation of estrogen
receptors and RNA polymerase III. Cancer Res. 77: 4934"
Lingyan Jin et al. Therapeutic targeting of the CBP/p300
bromodomain blocks the growth of castration-resistant
prostate cancer. Cancer Res. 77: 5564
Charlotte Moretti et al. SLY regulates genes involved inchromatin remodeling and interacts with TBL1XR1 during
sperm differentiation. Cell Death Differ. 24: 1029
Alison Iroz et al. A specific ChREBP and PPARα cross-talk
Is required for the glucose-mediated FGF21 response. Cell
Reports. 21: 403
Per Ludvik Brattas et al. TRIM28 controls a gene
regulatory network based on endogenous retroviruses inhuman neural progenitor cells. Cell Reports 18: 1
Daniela Grassi et al. Neuronal activity, TGFβ-Signaling
and unpredictable chronic stress modulate transcriptionof Gadd45 family members and DNA methylation in the
hippocampus. Cereb Cortex. 27: 4166
Endika Haro et al. Lmx1b-targeted cis-regulatory modules
involved in limb dorsalization. Dev. 444: 2009
Sylvia C. Hewitt et al. Role of ERa in mediating female
uterine transcriptional Responses to IGF1. Endocrinology.
158: 2427
Laurel A. Coons et al. DNA sequence constraints definefunctionally active steroid nuclear receptor binding sites inchromatin. Endocrinology. 158: 3212
John P. Thomson et al. Defining baseline epigenetic
landscapes in the rat liver. Epigenomics. 9: 1503

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

Target

MeDIP-Seq

JournalYear

Genes Brain
Behav.

2017

Reference

M. Fonteneau et al. Inhibition of DNA methyltransferases
regulates cocaine self-administration by rats: a genomewide DNA methylation study. Genes Brain Behav. 16:313
Leah Cushing et al. IRAK4 kinase activity controls Toll-likereceptor induced inflammation through the transcription
factor IRF5 in primary human monocytes. J Biol Chem.
292: 18689
Leah A. Gates et al. Acetylation on histone H3 lysine
9 mediates a switch from transcription initiation toelongation. J Biol Chem. 292: 14456
Huairui Yuan et al. Histone methyltransferase SETD2
modulates alternative splicing to inhibit intestinal
tumorigenesis. J Clin Invest. 127: 3375
Ni Li et al. AKT-mediated stabilization of histone
methyltransferase WHSC1 promotes prostate cancer
metastasis. J Clin Invest. 127: 1284
Lina Yang et al. The stem cell factor SALL4 is an essential
transcriptional regulator in mixed lineage leukemiarearranged leukemogenesis. J Hematol Oncol. 10: 159"Y Shen et al. Inactivation of KLF4 promotes T-cell acutelymphoblastic
leukemia and activates the MAP2K7 pathway. Leukemia.
31: 1314"
Khyobeni Mozhui et al. Conserved effect of aging on DNA
methylation and association with EZH2 polycomb protein
in mice and humans. Mech Ageing Dev. 162: 27
Carly T. Campbell et al. Mechanisms of Pinometostat (EPZ5676) treatment–emergent resistance in MLL-rearranged
leukemia. Mol Cancer Ther. 16: 1669
Dorothy Brach et al. EZH2 inhibition by tazemetostat
results in altered dependency on B-cell activation
signaling in DLBCL. Mol Cancer Ther. 16:2586
Claire Nash et al. Genome-wide analysis of AR binding
and comparison with transcript expression in primary
human fetal prostate fibroblasts and cancer associatedfibroblasts. Mol Cell Endocrinol. Advance online
publication doi: 10.1016/j.mce.2017.05.006
Nicolas Hipp et al. IL-2 imprints human naive B cell fate
towards plasma cell through ERK/ELK1-mediated BACH2
repression. Nat Commun. 8: 1443

ChIP-qPCR

IRF5, NFkB (p65)

J Biol Chem.

2017

ChIP-Seq

RNA Pol II

J Biol Chem.

2017

ChIP-Seq

H3K36me3

J Clin Invest.

2017

ChIP-Seq

H3K36me2

J Clin Invest.

2017

ChIP-Seq

SALL4

J Hematol Oncol.

2017

Next-Gen
BisulfiteSeq, ChIPSeq

KLF4

Leukemia

2017

ChIP-qPCR

EZH2Mech Ageing Dev.

2017

ChIP-Seq

H3K79me2

Mol Cancer Ther.

2017

ChIP-Seq

EZH2, H3K27me3,
H3K4me3

Mol Cancer Ther.

2017

ChIP-Seq

Androgen Receptor

Mol Cell
Endocrinol.

2017

ChIP-Seq

BACH2

Nat Commun.

2017

MeDIP-Seq

5-Methylcytosine

Nature2017

Rama S. Akondy et al. Origin and differentiation of humanmemory CD8 T cells after vaccination. Nature. 552: 362

ChIP-Seq

10 different Histonemods, CTCF, RNAPol II, BRD4Nature2017

Elizabeth Stewart et al. Orthotopic patient-derived
xenografts of paediatric solid tumours. Nature. 549: 96

ChIP-Seq

BRD4, H3K9me3,
RNA Pol II

Neuron2017

ChIP-Seq

SRC-2

PLoS Genet.

2017

North America 877 222 9543

Europe +32 (0)2 653 0001

Issam Aldiri et al. The dynamic epigenetic landscapeof the retina during development, reprogramming andtumorigenesis. Neuron. 94: 550
Shruthy Suresh et al. SRC-2-mediated coactivation of antitumorigenic target genes supresses MYC-induced livercancer. PLoS Genet. 13: e1006650

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear
2017

Reference

Yongfeng Liu et al. Epithelial EZH2 serves as anepigenetic determinant in experimental colitis by
inhibiting TNFα-mediated inflammation and apoptosis.
Proc Natl Acad Sci. 114: E3796
Zhen Zhang et al. Transcription factor Etv5 is essential forthe maintenance of alveolar type II cells. Proc Natl Acad
Sci. 114: E3903

ChIP-Seq

EZH2

Proc Natl Acad
Sci USAChIP-Seq

ETV5

Proc Natl Acad
Sci USA2017

ChIP-Seq
Data Analy- H3K27me3
sis

Sci Rep.

2017

ChIP-Seq

CBX3/HP1

Sci Rep.

2017

ChIP-Seq

H3K27ac

Sci Rep.

2017

ChIP-qPCR

SIRT1

Sci Rep.

2017

Low Cell
ChIP-Seq

H3K4me3,
H3K27ac, H3K27me3

Biol Reprod.

2016

ChIP-Seq

OTX2, MITF, BRD4,
H3K27acCancer Cell

2016

ChIP-Seq

HDAC1, H3K27ac

Cancer Discov.

2016

ChIP-Seq

H3K27me3

Cancer Res.

2016

ChIP-Seq

GATA2, Progesterone Receptor

Cell Rep.

2016

ChIP-qPCR

Androgen Receptor

Cell Rep.

2016

Karyn Schmidt et al. The lncRNA SLNCR1 mediates
melanoma invasion through a conserved SRA1-like region.
Cell Rep. 15: 2025

ChIP-Seq,
Spike-in

KDM5C

Cell Rep.

2016

Shigeki Iwase et al. A mouse model of X-linked intellectual
disability associated with impaired removal of histone
methylation. Cell Reports. 14: 1

Dev Dyn.

2016

Oyvind Dahle et al. Inhibiting smad2/3 signaling inpluripotent mouse embryonic stem cells enhancesendoderm formation by increasing transcriptional Primingof lineage-specifying target genes. Dev Dyn. 245: 807

Development

2016

eLife

2016

ChIP Libraries, ChIPSeq, ChIP- H3K27me3
Seq Data
Analysis
ChIP-Seq

PLZF, SALL4

ChIP-Seq,
ChIP-qPCR

WIZNorth America 877 222 9543

Europe +32 (0)2 653 0001

Brid O'Leary et al. Long non-coding RNA PARTICLE
bridges histone and DNA methylation. Sci Rep. 7: 1790
Michael Sun et al. Cbx3/HP1γ deficiency confers
enhanced tumor-killing capacity on CD8+ T cells. Sci Rep.
7: 42888
Yao Shen et al. Epigenetic and genetic dissections of UVinduced global gene dysregulation in skin cells throughmulti-omics analyses. Sci Rep. 7: 42646
Jung-Yoon Yoo et al. KRAS activation and overexpression of SIRT1/BCL6 contributes to the pathogenesisof endometriosis and progesterone resistance. Sci Rep. 7:
6765
Kazadi Mutoji et al. TSPAN8 expression distinguishes
spermatogonial stem cells in the prepubertal mouse
testis. Biol Reprod. 95: 17.
Pascal D. Johann et al. Atypical teratoid/rhabdoid tumors
are comprised of three epigenetic subgroups with distinct
enhancer landscapes. Cancer Cell. 29: 379
Anjali Mishra et al. Mechanism, consequences, andtherapeutic targeting of abnormal IL15 signaling in
cutaneous T-cell lymphoma. Cancer Discov. 6: 986
John P. Thomson et al. Loss of Tet1 associated
5-hydroxymethylcytosine is concomitant with aberrant
promoter hypermethylation in liver cancer. Cancer Res.
76: 3097
Cory A. Rubel et al. A Gata2-dependent transcription
network regulates uterine progesterone responsivenessand endometrial function. Cell Reports. 17: 1414

Dawn L. Lovelace et al. The regulatory repertoire of
PLZF and SALL4 in undifferentiated spermatogonia.
Development. 143:1893
Luke Isbel et al. Wiz binds active promoters and CTCFbinding sites and is required for normal behaviour in themouse. Elife. 5: e15082
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

H3K27ac, RNA Pol
II, JDP2

Genome Res.

2016

ChIP-Seq

V5-tagged DUX4

Hum Mol Genet.

2016

ChIP-Seq

LL-37 (antimicrobial
peptide)J Cancer

2016

ChIP-Seq,
Spike-in

BRD4

J Clin Invest.

2016

ChIP-Seq

Myc-tagged PET-1

J Neurosci.

2016

ChIP-Seq

Androgen Receptor, Estrogen
Receptor

Mol Cancer Res.

2016

ChIP-Seq

Androgen Receptor

Mol Cell

2016

ChIP-Seq

H3K27me3

Mol Cell Biol.

2016

ChIP-Seq,
ChIP-qPCR

p53

Mol Oncol.

2016

hMeDIPSeq

5-Hydroxymethylcytosine

Nat Commun.

2016

Low Cell
ChIP-Seq

H3K27me3, CTCF

Nat Genet.

2016

ChIP-Seq

H3K27acNat Genet.

2016

ChIP-Seq

BRD4, H3K27ac,
H3K4me1, H3K27me3, HLX, LHX2,LMX1A

Nature2016

ChIP-qPCR

H3K9me3, H3 panNucleic Acids Res.
acetyl2016

ChIP-Seq,
ChIP-qPCR

H3K36me3

Oncogene

2016

ChIP-Seq

MTA1

Oncotarget

2016

ChIP-Seq

PLZF

PLoS Genet.

2016

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference"Petros Kolovos et al. Binding of nuclear factor κB to
noncanonicalconsensus sites reveals its multimodal role during theearly inflammatory response. Genome Res. 26:1478"
Jocelyn O. Eidahl et al. Mouse Dux is myotoxic and sharespartial functional homology with its human paralog DUX4.
Hum Mol Genet. 25: 4577
Mindy Munoz et al. Antimicrobial peptide LL-37
participates in the transcriptional regulation of melanoma
cells. J Cancer. 26: 2341
Mark L. McCleland et al. CCAT1 is an enhancer-templated
RNA that predicts BET sensitivity in colorectal cancer. J
Clin Invest. 126: 639
Steven C. Wyler et al. Pet-1 switches transcriptional targets
postnatally to regulate maturation of serotonin neuron
excitability. J Neurosci. 36:1758
Nicholas D'Amato et al. Cooperative Dynamics of AR and
ER Activity in Breast Cancer. Mol Cancer Res. 14:1054
Boyu Zhang et al. Non-Cell-Autonomous Regulation of
Prostate Epithelial Homeostasis by Androgen Receptor.
Mol Cell. 63: 976
Kyung Hyun Yoo et al. Histone demethylase KDM6A
controls the mammary luminal lineage through enzymeindependent mechanisms. Mol Cell Biol. 36: 2108
Cheryl Chan et al. Global re-wiring of p53 transcription
regulation by the hepatitis B virus X protein. Mol Oncol.
10: 1183
Carolina M. Greco et al. DNA hydroxymethylation controls
cardiomyocyte gene expression in development andhypertrophy. Nat Commun. 7: 12418
Joachim Weischenfeldt et al. Pan-cancer analysis ofsomatic copy-number alterations implicates IRS4 and
IGF2 in enhancer hijacking. Nat Genet. 49: 65
Pratiti Bandopadhayay et al. MYB-QKI rearrangements
in angiocentric glioma drive tumorigenicity through a
tripartite mechanism. Nat Genet. 48: 273
Charles Y. Lin et al. Active medulloblastoma enhancers
reveal subgroup-specific cellular origins. Nature. 530: 57
Xiaoyu Chen et al. Probing the impact of chromatin
conformation on genome editing tools. Nucleic Acids Res.
44: 6482
Thai H. Ho et al. High-resolution profiling of histone h3
lysine 36 trimethylation in metastatic renal cell carcinoma.
Oncogene. 35: 1565
Swati Dhar et al. Dietary pterostilbene is a novel MTA1targeted chemopreventive and therapeutic agent inprostate cancer. Oncotarget. 7: 18469
Ramakrishna Kommagani et al. The Promyelocytic
leukemia zinc finger transcription factor Is critical forhuman endometrial stromal cell decidualization. PLoS
Genet. 12: e1005937
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq,
Spike-in

H3K27me3, H3K4me3, H3K9me3

PLoS One2016

ChIP-Seq

HDAC1, HDAC2,GATA2PLoS One2016

ChIP-Seq

NR4A1

PLoS One2016

ChIP-Seq,
ChIP-qPCR

H3K9AcStem Cells Transl
Med.

2016

ChIP-Seq

FLAG-tagged
TWIST2

Am J Hum Genet.

2015

ChIP-Seq

H3K4me1

BMC Biol.

2015

ChIP-Seq

FOXM1

Breast Cancer
Res Treat.

2015

ChIP-Seq

SIX1

Cancer Cell

2015

ChIP-Seq,
ChIP-qPCR

b-Arrestin-1

Cancer Res.

2015

ChIP-Seq

Progesterone Receptor

Cell Rep.

2015

ChIP-Seq

H3K9Ac, RNA Pol
II, TFIIB

Circ Heart Fail.

2015

ChIP-Seq

HA-tagged SHOX2Development

2015

ChIP-qPCR

EZH2, SUZ12,
H3K27me3, RNAPol IIEMBO J.

2015

ChIP-Seq

Progesterone Receptor, FOSL2

Endocrinology

2015

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Brian Egan et al. An alternative approach to ChIP-Seq
normalization enables detection of genome- widechanges in histone H3 lysine 27 trimethylation upon EZH2
inhibition. PLoS One. 11: e0166438"Jeffrey R. Shearstone et al. Chemical Inhibition of histone
deacetylases
1 and 2 Induces fetal hemoglobin through activation of
GATA2. PLoS One. 11: e0153767"
Ryan P. Duren et al. Genome wide mapping of NR4A
binding reveals cooperativity with ETS factors to promoteepigenetic activation of distal enhancers in acute myeloid
leukemia cells. PLoS One. 11: e0150450
Dalia Ali et al. Epigenetic library screen identifies
abexinostat as novel regulator of adipocytic andosteoblastic differentiation of human skeletal(mesenchymal) stem cells. Stem Cells Transl Med. 5: 1036
Shannon Marchegiani et al. Recurrent mutations in thebasic domain of TWIST2 cause ablepharon macrostomia
and barber-say syndromes. Am J Hum Genet. 97: 99
Sara K. Harten et al. The recently identified modifier ofmurine metastable epialleles, Rearranged L-Myc Fusion,is involved in maintaining epigenetic marks at CpG island
shores and enhancers. BMC Biol. 13: 21
Christina Yau et al. FOXM1 cistrome predicts breast
cancer metastatic outcome better than FOXM1 expression
levels or tumor proliferation index. Breast Cancer Res
Treat. 154: 23
Jenny Wegert et al. Mutations in the SIX1/2 pathway andthe DROSHA/DGCR8 miRNA microprocessor complex
underlie high-risk blastemal type Wilms tumors. Cancer
Cell. 27: 298
Smitha Pillai et al. β-arrestin-1 mediates nicotine-induced
metastasis through E2F1 target genes that modulate
epithelial-mesenchymal transition. Cancer Res. 75: 1009
Vincent J. Lynch et al. Ancient transposable elements
transformed the uterine regulatory landscape andtranscriptome during the evolution of mammalianpregnancy. Cell Rep. 10: 551
Danish Sayed et al. Acute targeting of generaltranscription factor IIB restricts cardiac hypertrophy via
selective inhibition of gene transcription. Circ Heart Fail.
8: 138Wenduo Ye et al. A common Shox-2-Nkx2-5 antagonistic
mechanism primes the pacemaker cell fate in thepulmonary vein myocardium and sinoatrial node.
Development. 142: 2521
Stephen G. Dann et al. Reciprocal regulation of aminoacid import and epigenetic state through Lat1 and EZH2.
EMBO J. 34: 1773
Erik C. Mazur et al. Progesterone receptor transcriptome
and cistrome in decidualized human endometrial stromalcells. Endocrinology. 156: 2239

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

Target

ChIP-Seq

H3K4me3, H3K9me3

ChIP-Seq

LHX6

ChIP-Seq

H3K27me3, H3K4me1, H3K4me3,
H3K27ac, p300,
RARα

Next-Gen
BisulfiteSeq

JournalYear

Epigenetics

2015

Hum Mol Genet.

2015

Immunity

2015

J Clin Invest.

2015

ChIP-Seq

H3K4me3

J Natl Cancer Inst.

2015

ChIP-Seq

BRD4

Mol Cancer Ther.

2015

ChIP-Seq

BAF180/PBRM1

Mol Cell

2015

ChIP-Seq

ZNF384

Mol Endocrinol.

2015

ChIP-Seq

FOXO1, RNA Pol II

Mol Endocrinol.

2015

ChIP-Seq

EGR2

Nat Commun.

2015

ChIP-Seq

SOX9

Nucleic Acids Res.

2015

ChIP-Seq

H3K27me3

Nucleic Acids Res.

2015

ChIP-Seq

CCND1 (Cyclin D1)

Oncotarget

2015

ChIP-Seq
Data Analy- KDM3A
sis

PLoS Biol.

2015

ChIP-Seq

TRIM33

PLoS Genet.

2015

ChIP-Seq

EGR1

PLoS One2015

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Nioka C. Chisholm et al. Histone methylation patterns
in astrocytes aer influenced by age following ischemia.
Epigenetics. 10: 142"Jeffry M. Cesario et al. Lhx6 and Lhx8 promote palate
development throughnegative regulation of a cell cycle inhibitor gene,
p57Kip2. Hum Mol Genet. 24: 5024"
Chrysothemis C. Brown et al. Retinoic acid is essential forTh1 cell lineage stability and prevents transition to a Th17
cell progrm. Immunity. 42: 1
Coralie Hoareau-Aveilla et al. Reversal of microRNA-150
silencing disadvantages crizotinib-resistant NPM-ALK(+)
cell growth. J Clin Invest. 125: 3505
Cristian Taccioli et al. Repression of esophageal neoplasia
and inflammatory signaling by anti-miR-31 delivery in vivo.
J Natl Cancer Inst. 107: djv220
Ryan Lenhart et al. Sensitivity of small cell lung cancer to
BET inhibition is mediated by regulation of ASCL1 gene
expression. Mol Cancer Ther. 14: 2167
Bokai Zhu et al. Coactivator-dependent oscillation ofchromatin accessibility dictates circadian gene amplitude
via REV-ERB loading. Mol Cell. 60: 769
Paul Childress et al. Genome-wide mapping andinterrogation of the Nmp4 anti-anabolic bone axis. Mol
Endocrinol. 29: 1269
Yasmin M. Vasquez et al. FOXO1 is required for binding of
PR on IRF4, novel transcriptional regulator of endometrial
stromal decidualization. Mol Endocrinol. 29: 421
Tomohisa Okamura et al. TGF-b3-expressing CD4+CD25LAG3+ regulatory T cells control humoral immune
responses. Nat Commun. 6: 6329
Zhongcheng Shi et al. Context-specific role of SOX9 in
NF-Y mediated gene regulation in colorectal cancer cells.
Nucleic Acids Res. 43: 6257
Kyung Hyun Yoo et al. Loss of EZH2 results in precocious
mammary gland development and activation of STAT5dependent genes. Nucleic Acids Res. 43: 8774
Mathew C. Casimiro et al. Kinase-independent roleof cyclin D1 in chromosomal instability and mammary
tumorigenesis. Oncotarget. 6: 8524
Mo-bin Cheng et al. Specific phosphorylation of histone
demethylase KDM3A determines target gene expression
in response to heat shock. PLOS Biol. 12: e1002026
Luke Isbel et al. Trim33 binds and silences a classof young endogenous retroviruses in the mouse
testis; a novel component of the arms race between
retrotransposons and the host genome. PLoS Genet. 11:e1005693
Anthony A. Portale et al. Characterization of FGF23dependent Egr-1 cistrome in the mouse renal proximal
tubule. PLoS One. 10: e0142924
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

RARα, RARβ, RXRαAm J Physiol
Gastrointest Liver
Physiol.

2014

ChIP-Seq

H3K27me3

Bioinformatics

2014

ChIP-Seq

PPARg

Biol Reprod.

2014

Cell Rep.

2014

Next-Gen
BisulfiteSeq
ChIP-Seq

SRC-2

Cell Rep.

2014

ChIP-Seq,
ChIP-qPCRZBTB20

Cereb Cortex

2014

ChIP-Seq

H3K9me3, H3K36me3, H3K27me3

Genome Res.

2014

ChIP-Seq

H3K36me3

Genome Res.

2014

ChIP-Seq

H3K27ac

J Biol Chem.

2014

ChIP-Seq,
ChIP-qPCR

SRC-3

J Clin Invest.

2014

ChIP-Seq,
ChIP-qPCRZBTB20J Med Genet.

2014

ChIP-qPCR

EZH2, SUZ12,
H3K27me3

Mol Cancer Ther.

2014

ChIP-Seq

Fish H3K4me3

Mol Ecol Resour.

2014

ChIP-Seq

SRC-1

Mol Endocrinol.

2014

ChIP-Seq

Estrogen Receptor

Mol Endocrinol.

2014

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Yuqi He et al. Biological functional annotation of retinoic
acid alpha and beta in mouse liver based on genomewide binding. Am J Physiol Gastrointest Liver Physiol. 307:
G205
Yanxiao Zhang et al. PePr: A peak-calling prioritization
pipeline to identify consistent or differential peaks from
replicated ChIP-Seq data. Bioinformatics. 30: 2568
Kelsey E. Brooks et al. Peroxisome proliferator activator
receptor gamma (PPARg) regulates conceptus elongationin sheep. Biol Reprod. 92: 42.
Deepak Kumar et al. Fibroblast growth factor maintains
chondrogenic potential of limb bud mesenchymal cells by
modulating DNMT3A recruitment. Cell Rep. 8: 1419
Erin Stashi et al. SRC-2 Is an essential coactivator fororchestrating metabolism and circadian rhythm. Cell Rep.
6: 633
Jakob V. Nielsen et al. Zbtb20 Defines a hippocampal
neuronal identity through direct repression of genes that
control projection neuron development in the isocortex.
Cereb Cortex. 24: 1216
Goran Kungulovski et al. Application of histone
modification-specific interaction domains as an alternative
to antibodies. Genome Res. 24: 1842
Jeremy M. Simon et al. Variation in chromatin accessibility
in human kidney cancer links H3K36 methyltransferase
loss with widespread RNA processing defects. Genome
Res. 24: 241
Andre Landin Malt et al. Identification of a face enhancer
reveals direct regulation of LIM homeobox 8 (Lhx8) bywingless-int (WNT)/β-catenin Signaling. J Biol Chem. 289:
30289
Jun Qin et al. Androgen deprivation–induced NCoA2
promotes metastatic and castration-resistant prostatecancer. J Clin Invest. 124: 5013
Malene B. Rasmussen et al. Neurodevelopmental
disorders associated with dosage imbalance of ZBTB20
correlate with the morbidity spectrum of ZBTB20
candidate target genes. J Med Genet. 51: 605
Sarah K. Knutson et al. Selective inhibition of EZH2 by
EPZ-6438 leads to potent antitumor activity in EZH2
mutant Non-Hodgkin lymphoma. Mol Cancer Ther. 13: 842
Claudius F. Kratochwil et al. Mapping active promoters by
ChIP-seq profiling of H3K4me3 in cichlid fish – a first stepto uncover cis-regulatory elements in ecological model
teleosts. Mol Ecol Resour. 15: 761
Mounia Tannour-Louet et al. Hepatic SRC-1 activity
orchestrates transcriptional circuitries of amino acid
pathways with potential relevance for human metabolic
pathogenesis. Mol Endocrinol. 28: 1707
Sylvia C. Hewitt et al. Novel DNA motif binding activity
observed In vivo with an estrogen receptor a mutant
mouse. Mol Endocrinol. 26: 899

Japan +81 (0)3 5225 3638

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Technique
ChIP-Seq

TargetH3K4me3, H3K27me3

Next-Gen
BisulfiteSeq

JournalYear

Nat Commun.

2014

Nat Neurosci.

2014

ChIP-Seq

H3K9ac, H3K27Ac

Nature2014

ChIP-Seq

H3K4me3, H3K27me3

Nature2014

ChIP-Seq,
ChIP-qPCR

SRF

Physiol Genomics

2014

ChIP-Seq,
PXR, p300, H3KLightSwitch 4me1, H3K27ac

PLoS Genet.

2014

Proc Natl Acad
Sci USA2014

ChIP-Seq

GATA2, FOXA1,
p300, CBP, SRC-1,
SRC-2, SRC-3, Androgen Receptor

ChIP-Seq

Vitamin D Receptor

BMC Med.

2013

ChIP-Seq

H3K27me3

Cancer Cell

2013

ChIP-Seq

H3K36me3

Cancer Discov.

2013

ChIP-Seq

CCND1 (Cyclin D1)Cancer Res.

2013

ChIP-SeqPPARαChem Biol
Interact.

2013

Clin Cancer Res.

2013

Next-Gen
BisulfiteSeq
ChIP-Seq

COUP-TFII (NR2F2)

Dev Cell

2013

ChIP-Seq

FOXA2

EMBO J.

2013

ChIP-Seq

RNA Pol II

J Allergy Clin
Immunol.

2013

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Brian C. Belyea et al. Identification of renin progenitors in
the mouse bone marrow that give rise to B-cell leukaemia.
Nat Commun. 5: 3273
Brian G. Dias et al. Parental olfactory experience
influences behavior and neural structure in subsequent
generations. Nat Neurosci. 17: 89
Paul A. Northcott et al. Enhancer hijacking activates GFI1
family oncogenes in medulloblastoma. Nature. 511: 428
Volker Hovestadt et al. Decoding the regulatory
landscape of medulloblastoma using DNA methylation
sequencing. Nature. 510: 537
Sharolyn V. Kawakami-Schulz. Serum response factor:
positive and negative regulation of an epithelial gene
expression network in the destrin mutant cornea. Physiol
Genomics. 46: 277
Robin P. Smith et al. Genome-wide discovery of drugdependent human liver regulatory elements. PLOS Genet.
10: e1004648
Bin He et al. GATA2 facilitates steroid receptor coactivator
recruitment to the androgen receptor complex. Proc Natl
Acad Sci. 111: 18261
Adam E. Handel et al. Vitamin D receptor ChIPseq in primary CD4+ cells: relationship to serum
25-hydroxyvitamin D levels and autoimmune disease.
BMC Med. 11: 163
Sebastian Bender et al. Reduced H3K27me3 and DNA
hypomethylation are major drivers of gene expression in
K27M mutant pediatric high-grade gliomas. Cancer Cell.
24: 660
Lynn Bjerke et al. Histone H3.3 Mutations Drive PediatricGlioblastoma through Upregulation of MYCN. Cancer
Discov. 3: 512
Xiaoming Ju et al. Identification of a cyclin D1 network inprostate cancer that antagonizes epithelial-mesenchymal
restraint. Cancer Res. 74: 508
Patrick D. McMullen et al. A map of the PPARαtranscription regulatory network for primary humanhepatocytes. Chem Biol Interact. 209: 14
David S. Shames et al. Loss of NAPRT1 expression bytumor-specific promoter methylation provides a novel
predictive biomarker for NAMPT inhibitors. Clin Cancer
Res. 19: 6912
San-pin Wu et al. Atrial identity is determined by a COUPTFII regulatory network. Dev Cell. 25: 417
Justyna Filant et al. Integrated chromatin
immunoprecipitation sequencing and microarray analysis
identifies FOXA2 target genes in the glands of the mouseuterus. FASEB J. 28: 230
Purvi Mehrotra et al. PARP-14 and its enzyme activity
regulates Th2 differentiation and allergic airway disease. J
Allergy Clin Immunol. 131: 521

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-qPCR

NFkB (p52 andp65)

J Biol Chem.

2013

ChIP-chip,
ChIP-qPCR

C/EBPβ, RNA Pol II

J Biol Chem.

2013

ChIP-Seq

KDM2B

J Clin Invest.

2013

ChIP-Seq

ASXL1

J Exp Med.

2013

ChIP-Seq

NR2F2

Mol Endocrinol.

2013

ChIP-Seq

Progesterone Receptor

Mol Endocrinol.

2013

ChIP-qPCR

H3K9me3, H3

Nat Immunol.

2013

ChIP-Seq

GFI1

Nat Immunol.

2013

ChIP-Seq

p53

Physiol Genomics

2013

ChIP-Seq

MYRF

PLoS Biol.

2013

ChIP-Seq

p300

PLoS Genet.

2013

ChIP-Seq

RNA Pol II

PLoS One2013

ChIP-Seq,
ChIP-qPCR

RXRα, RNA Pol II

PLoS One2013

ChIP-Seq

H3K4me3

PLoS One2013

ChIP-Seq

Am J Physiol
Farnesoid X RecepGastrointest Liver
tor
Physiol.

2012

ChIP-Seq

Androgen Receptor

2012

North America 877 222 9543

BMC Genomics

Europe +32 (0)2 653 0001

Reference

Sarah L. Doyle et al. Nuclear factor κB2 p52 protein has
a role in antiviral immunity through IκB kinase epsilondependent induction of Sp1 protein and interleukin 15. J
Biol Chem. 288: 25066
Hana Vakili et al. CCAAT-enhancer-binding protein β (C/EBPβ) and downstream human placental growth hormone
genes are targets for dysregulation in pregnancies
complicated by maternal obesity. J Biol Chem. 288: 22849
Alexandros Tzatsos et al. KDM2B promotes pancreaticcancer via Polycomb-dependent and -independenttranscriptional programs. J Clin Invest. 123: 727
Omar Abdel-Wahab et al. Deletion of Asxl1 results inmyelodysplasia and severe developmental defects in vivo.
J Exp Med. 210: 2641
Xilong Li et al. COUP-TFII regulates human endometrial
stromal genes involved in inflamation. Mol Endocrinol. 27:
2041
Ashlee R. Lain et al. Research Resource: Progesterone
receptor targetome underlying mammary gland branchingmorphogenesis. Mol Endocrine. 27: 1743
Patrick M. Gubser et al. Rapid effector function of memory
CD8+ T cells requires an immediate-early glycolytic
switch. Nat Immunol. 14: 1064
Chauncey J. Spooner et al. Specification of type 2 innate
lymphocytes by the transcriptional determinant Gfi1. Nat
Immunol. 14: 1229
Yuwen Li et al. Genome-wide analysis of the p53 gene
regulatory network in the developing mouse kidney.
Physiol Genomics. 45: 948
Helena Bujalka et al. MYRF is a membrane-associatedtranscription factor that autoproteolytically cleaves todirectly activate myelin genes. PLoS Biol. 11: e1001625
Aaron M. Wenger et al. The enhancer landscape during
early neocortical development reveals patterns of dense
regulation and co-option. PLoS Genet. 9: e1003728
Jonathan P. Riley et al. PARP-14 binds specific DNA
sequences to promote Th2 cell gene expression. PLoS
One. 8: e83127
Astrid Kosters et al. Sexually dimorphic genome-widebinding of retinoid X receptor alpha (RXRa) determines
male-female differences in the expression of hepatic lipid
processing genes in mice. PLoS One. 8: e71538
Alex Gutteridge et al. Novel pancreatic endocrine
maturation pathways identified by genomic profiling andcausal reasoning. PLoS One. 8: e56024.
Julia Yue Cui et al. Bile acids via FXR initiate theexpression of major transporters involved in theenterohepatic circulation of bile acids in newborn mice.
Am J Physiol Gastrointest Liver Physiol. 302: G979
Zhou Zhu et al. Dose-dependent effects of small-molecule
antagonists on the genomic landscape of androgen
receptor binding. BMC Genomics. 13: 355

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-Seq

RNA Pol II

Cardiovasc Res.

2012

ChIP-qPCR

PDX1, TCF3

Chem Biol.

2012

ChIP-Seq

RNA Pol II

J Biol Chem.

2012

ChIP-Seq

NKX3.1J Clin Invest.

2012

ChIP-Seq

FLAG-tagged
CCND1 (Cyclin D1)

J Clin Invest.

2012

ChIP-Seq

LSD1, H3K4me2

Mol Cell Biol.

2012

ChIP-Seq

Progesterone Receptor

Mol Endocrinol.

2012

ChIP-Seq

Estrogen Receptor,
RNA Pol II

Mol Endocrinol.

2012

Nat Struct Mol
Biol.

2012

ChIP-Seq
Data Analy- pTyr37 H2B
sis
ChIP-Seq

EZH2

Nature2012

ChIP-Seq

Glucocorticoid
Receptor

PLoS One2012

ChIP-chip

B-MYB

PLoS One2012

ChIP-chip

RORa

PLoS One2012

ChIP-Seq

Progesterone Receptor

PLoS One2012

ChIP-Seq

FLAG-tagged BAP1,
OGT, HCF1

Science2012

ChIP-Seq

RBPJ

Stem Cells

2012

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Mingyue Han et al. GATA4 expression is primarily
regulated via a miR-26b-dependent post-transcriptional
mechanism during cardiac hypertrophy. Cardiovasc Res.
93: 645
Alice Kiselyuk et al. HNF4α antagonists discovered bya high-throughput screen for modulators of the humaninsulin promoter. Chem Biol. 19:806
Danish Sayed et al. Transcriptional regulation
patterns revealed by high-resolution chromatin
immunoprecipitation during cardiac hypertrophy. J Biol
Chem. 288: 2546
Philip D. Anderson et al. Nkx3.1 and Myc crossregulateshared target genes in mouse and human prostate
tumorigenesis. J Clin Invest. 122: 1907
Mathew C. Casimiro et al. ChIP sequencing of cyclin D1
reveals a transcriptional role in chromosomal instability inmice. J Clin Invest. 122: 833
Venugopalan D. Nair et al. Involvement of histone
demethylase LSD1 in short-time-scale gene expression
changes during cell cycle progression in embryonic stem
cells. Mol Cell Biol. 32: 4861
Cory A. Rubel et al. Genome-Wide Profiling ofProgesterone Receptor Binding in the Mouse Uterus. Mol
Endocrinol. 26: 1428
Sylvia C. Hewitt et al. Whole-Genome Estrogen Receptor
Binding in Mouse Uterine Tissue Revealed by ChIP-Seq.
Mol Endocrinol. 26: 887
Kiran Mahajan et al. H2B Tyr37 phosphorylation
suppresses expression of replication­dependent core
histone genes. Nat Struct Mol Biol. 19: 930
Michael T. McCabe et al. EZH2 inhibition as a therapeuticstrategy for lymphoma with EZH2-activating mutations.
Nature. 492: 108
Marie-Jose ́ C. van Lierop et al. Org 214007-0: A novel
non-steroidal Selective glucocorticoid receptor modulator
with full anti-inflammatory properties and improved
therapeutic index. PLoS One. 7: e48385
Ming Zhan et al. The B-MYB transcriptional network
guides cell cycle progression and fate decisions to sustain
self-renewal and the identity of pluripotent stem cells.
PLoS One. 7: e42350
Yongjun Wang et al. Regulation of p53 Stability and
Apoptosis by a ROR Agonist. PLoS One. 7: e34921
Ping Yin et al. Genome-wide progesterone receptor
binding: cell type- specific and shared mechanisms in
T47D breast cancer cells and primary leiomyoma cells.
PLoS One. 7: e29021
Anwesha Dey et al. Loss of the tumor suppressor BAP1
causes myeloid transformation. Science. 337: 1541
Yaochen Li et al. Genome-wide Analysis of N1ICD/RBPJ
Targets in vivo Reveals Direct Transcriptional Regulationof Wnt, SHH, and Hippo Pathway Effectors by Notch1.
Stem Cells. 30: 741
Japan +81 (0)3 5225 3638

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Technique

TargetJournalYear

Allergy

2011

ChIP-chip

IRF4

ChIP-qPCR

Progesterone Receptor

Biochem
Pharmacol.

2011

MeDIP-chip

5-Methylcytosine

BMC Biol.

2011

ChIP-qPCR

IRF4, cMyc

Br J Haematol.

2011

ChIP-qPCRCTCF

DNA Cell Biol.

2011

ChIP-chip

Progesterone Receptor

EMBO J.

2011

ChIP-qPCR

PPARg

Invest Ophthalmol
Vis Sci.

2011

ChIP-Seq

NELF-b (COBRA1)

J Biol Chem.

2011

ChIP-chip

RNA Pol II, H3K9Ac

J Biol Chem.

2011

ChIP-chip

LXR, RXR

J Biol Chem.

2011

ChIP-chip

C/EBPbJ Mol Endocrinol.

2011

ChIP-Seq

MSGN1

Nat Commun.

2011

ChIP-Seq

FOXP3

Nucleic Acids Res.

2011

ChIP-chip

DAF-12

PLoS Genet.

2011

PLoS One2011

Next-Gen
BisulfiteSeq
North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Barrenas S Bruhn et al. Increased expression of IRF4 and
ETS1 in CD4+ cells from patients with intermittent allergic
rhinitis. Allergy. 67: 33
Mattew R Yudt et al. Discovery of a novel mechanism ofsteroid receptor antagonism: WAY-255348 modulates
progesterone receptor cellular localization and promoter
interactions. Biochem Pharmacol. 82: 1709
Genevieve Lavoie et al. PKC isoforms interact with andphosphorylate DNMT1. BMC Biol. 9: 31
Antonia Lopez-Girona et al. (2011) Lenalidomide
downregulates the cell survival factor, interferon
regulatory factor-4, providing a potential mechanistic linkfor predicting response. Br J Haematol. 154: 325"Yan Jin et al. Enhancer-Blocking Activity Is Associatedwith Hypersensitive Site V Sequences in the Human
Growth Hormone Locus Control Region. DNA Cell Biol.
30: 995"
Heather L. Franco et al. Epithelial progesterone receptor
exhibits pleiotropic roles in uterine development andfunction. FASEB J. 26: 1218
Gerard A Rodriques et al. Differential Effects of PPARg
Ligands on Oxidative Stress–Induced Death of Retinal
Pigmented Epithelial Cells. Invest Ophthalmol Vis Sci. 52:
890"Jianlong Sun et al. Genetic and Genomic Analyses of RNAPolymerase II-pausing Factor in Regulation of MammalianTranscription and Cell
Growth. J Biol Chem. 286: 36248"
Hong Hao et al. The Transcription Factor NRL Controls
Photoreceptor-specific Expression of Myocyte Enhancer
Factor Mef2c from an Alternative Promoter. J Biol Chem.
286: 34893"Qi Shen et al. Liver X Receptor-Retinoid X Receptor (LXRRXR) Heterodimer Cistrome Reveals Coordination of LXR
and AP1 Signaling in
Keratinocytes. J Biol Chem. 286: 14554"
Aristides Lytras et al. Identification of functional CCAAT/
enhancer-binding protein and Ets protein binding sites
in the human chorionic somatomammotropin enhancer
sequences. J Mol Endocrinol. 47: 179
Ravindra B Chalamalasetty et al. The Wnt3a/β-catenintarget gene Mesogenin1 controls the segmentation clockby activating a Notch signalling program. Nat Commun. 2:390
Fabian Birzele et al. Next-generation insights into
regulatory T cells: expression profiling and FoxP3
occupancy in Human. Nucleic Acids Res. 39: 7946
Daniel Hochbaum et al. DAF-12 Regulates a Connected
Network of Genes to Ensure Robust Developmental
Decisions. PLoS Genet. 7: e1002179
Michela Deleidi et al. Oct4-Induced Reprogramming Is
Required for Adult Brain Neural Stem Cell Differentiation
into Midbrain Dopaminergic Neurons. PLoS ONE. 6:e19926
Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournalYear

ChIP-qPCR

BRD4Proc Natl Acad
Sci USA2011

ChIP-chipp73

Proc Natl Acad
Sci USA2011

ChIP-qPCR

Aryl Hydrocarbon
Receptor

Toxicol Appl
Pharmacol.

2011

ChIP-qPCR

NFkB (p50 and
p65)

Cardiovasc Res.

2010

ChIP-Seq

Vitamin D Receptor

Genome Res.

2010

ChIP-qPCR

MAF1, RPC39,mTOR, BRF1, Raptor

J Biol Chem.

2010

ChIP-qPCR

p73

Mol Cancer

2010

ChIP-Seq

SRC-3, RNA Pol II

Mol Endocrinol.

2010

ChIP-chip

Androgen Receptor

Mol Endocrinol.

2010

ChIP-chip

RNA Pol II

Mol Vis.

2010

ChIP-qPCR

Aryl Hydrocarbon
Receptor, cMaf

Nat Immunol.

2010

ChIP-qPCR

Myc-tagged PET-1

Nat Neurosci.

2010

ChIP-Seq

Pregnane X RecepNucleic Acids Res.
tor

2010

ChIP-chip

O-GlcNAc, RNAPol II

Proc Natl Acad
Sci USA2010

ChIP-Seq

Pregnane X Receptor

Toxicol Sci.

2010

ChIP-chip

Aryl Hydrocarbon
Receptor

Toxicol Sci.

2010

North America 877 222 9543

Europe +32 (0)2 653 0001

Reference

Jennifer A. Mertz et al. Targeting MYC dependence incancer by inhibiting BET bromodomains. Proc Natl Acad
Sci. 108:16669
Jennifer M Rosenbluth et al. Differential regulation of thep73 cistrome by mammalian target of rapamycin reveals
transcriptional programs of mesenchymal differentiationand tumorigenesis. Proc Natl Acad Sci. 108: 2076
K Nadira De Abrew et al. Regulation of Bach2 by the arylhydrocarbon receptor as a mechanism for suppression of
B-cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Toxicol Appl Pharmacol. 252: 150
Alina G Sofronescu et al. FGF-16 is a target for adrenergic
stimulation through NF-kB activation in postnatal cardiac
cells and adult mouse heart. Cardiovasc Res. 87: 102
Sreeram V Ramagopalan et al. A ChIP-seq defined
genome-wide map of vitamin D receptor binding:
Associations with disease and evolution. Genome Res. 20:
1352
Boris Shor et al. Requirement of the mTOR Kinase for the
Regulation of Maf1 Phosphorylation and Control of RNAPolymerase III-dependent Transcription in Cancer Cells. J
Biol Chem. 286: 15380
Kathryn G Eby et al. ISG20L1 is a p53 family target genethat modulates genotoxic stress-induced autophagy. Mol
Cancer. 9: 95
Rainer B Lanz et al. Global Characterization ofTranscriptional Impact of the SRC-3 Coregulator. Mol
Endocrinol. 24: 859
Anastasia Wyce et al. The Androgen Receptor ModulatesExpression of Genes with Critical Roles in Muscle
Development and Function. Mol Endocrinol. 24: 1665
Padmaja Tummala et al. Temporal ChIP-on-Chip of RNAPolymerase-II to detect novel gene activation events
during photoreceptor maturation. Mol Vis. 16: 252
Lionel Apetoh et al. The aryl hydrocarbon receptor
interacts with c-Maf to promote the differentiation of type 1
regulatory T cells induced by IL-27. Nat Immunol. 11: 854
Chen Liu et al. Pet-1 is required across different stagesof life to regulate serotonergic function. Nat Neurosci. 13:
1190
Julia Yue Cui et al. ChIPing the cistrome of PXR in mouse
liver. Nucleic Acids Res. 38: 7943
Dona C Love et al. Dynamic O-GlcNAc cycling at
promoters of Caenorhabditis elegans genes regulating
longevity,stress, and immunity. Proc Natl Acad Sci. 107:
7413
Julia Yue Cui et al. Genetic and Epigenetic Regulation andExpression Signatures of Glutathione S-Transferases in
Developing Mouse Liver. Toxicol Sci. 116: 32
K Nadira De Abrewet al. An Integrated Genomic Analysis
of Aryl Hydrocarbon Receptor-Mediated Inhibition of B-Cell
Differentiation. Toxicol Sci. 118:454

Japan +81 (0)3 5225 3638

China (86) 21 20926090

Technique

TargetJournal

ChIP-chip

STAT4

J Immunol.

ChIP-Seq

p73

Mol Cell Biol.

ChIP-qPCR

Aryl Hydrocarbon
Receptor

North America 877 222 9543

NatureYear

Reference"Seth R Good et al. Temporal Induction Pattern of STAT4
Target2009
Genes Defines Potential for Th1 Lineage-Specific
Programming. J Immunol. 183: 3839"
Jennifer M Rosenbluth et al. A Gene Signature-Based2008 Approach Identifies mTOR as a Regulator of p73. Mol Cell
Biol. 28: 5951
Francisco J Quintana et al. Control of Treg and TH17 cell2008 differentiation by the aryl hydrocarbon receptor. Nature.
453: 65

Europe +32 (0)2 653 0001

Japan +81 (0)3 5225 3638

China (86) 21 20926090