第１４回 iCONM 学術セミナーのご案内
平素は大変お世話になっております。
以下の通り、iCONM 学術セミナー（共催：CHANGE）を開催いたします。オンラインの開催となりますので事前のお申込みをお願いいたします。

多くのご参加をお待ちしております。
2023 年 11 月 22 日
ナノ医療イノベーションセンター
イノベーション推進チーム
記
講演①
Title:
視床下部ニューロンとマイクログリアの探究：
肥満症治療のための戦略プラン
Speaker： ロザリア・R・ロドリゲス博士
Affiliation：カタルーニャ国際大学 (スペイン・バルセロナ)
准教授・バイオ医科学研究ユニット長
講演②
Title:
神経代謝モデル：
代謝性疾患に及ぼす脳の影響
Speaker： ザビエル・M・ベルベル博士
Affiliation：バルセロナ・マイクロエレクトロニクス研究所（スペイン）常勤研究員
日時： ２０２３年１２月１８日 午後２時～４時（討論を含む）
場所： Zoom ウェビナーによるオンライン開催
言語： 英語
事前参加登録：https://forms.gle/ac2U2N7RFeP1FW258
受付締切：１２月１２日（火）正午

Title：Exploring hypothalamic neurons and microglia: a strategic action plan to combat obesity
Abstract：
The continuously rising incidence and prevalence of obesity involves an urgent need to uncover new
molecular pathways with therapeutics potential. The brain, and in particular the hypothalamus, is a major
integrator of metabolic signals from peripheral tissues that regulates functions such as feeding behavior andenergy expenditure. The capacity of the hypothalamus to sense the nutritional state to maintain thesefunctions is altered in obesity. An emerging line of research has pointed out that neuronal lipid metabolism
and microglia dynamics play a critical role in regulating energy balance. Here we focus on neuronal carnitine
palmitoyltransferases 1 (CPT1), a family responsible for the metabolism of long-chain fatty acids, and on theJNK inflammatory pathway in both neurons and microglia. These are promising targets in the managementof appetite, body weight control and insulin resistance at early stages of the disease but also in aging.
Finally, the development of innovative platforms based on nanomedicines targeting these processes ineither neurons or microglia in the hypothalamus is a challenging but a potential next generation therapy totreat obesity.
Speaker： Rosalia Rodriguez-Rodriguez, PhD
Affiliation：Universitat Internacional de Catalunya (UIC Barcelona)
Position：Associate Professor,
Head of the Biomedical Sciences Unit UIC
URL：https://www.uic.es/neurolipid-grouphttps://www.uic.es/en/teacher/rrodriguez＜CV＞
Rosalia Rodriguez-Rodriguez, PhD in Pharmacology, Associate professor, and Head of Biomedicine in UIC
Barcelona, has more than 15 years’ research experience in the investigation of obesity and related
cardiometabolic complications in cellular and animal models, through national and internationalinstitutions. Her current research is the study the molecular mechanisms in the hypothalamus underlying
obesity and the generation of drug delivery systems for selective targeting of brain cells. She has been PI of
6 research national/international projects and participated in >15 projects related to this investigation. She
recently led a bilateral Spain-Japan project with Dr Quader (iCONM) to generate polymeric nanoparticles
targeting brain lipid metabolism. A major aim of her research is particularly related with targets in thehypothalamus of importance for energy homeostasis such as a carnitine palmitoyltransferases,endocannabinoid hydrolases, and JNK-related inflammatory pathways in neurons and microglia. Insummary, she has co-authored 76 publications (H index=25 and 1900 citations in Scopus) and 2 patents,supervised 16 students (undergraduates, master and PhD), 6 research awards, and is Associate Editor of thesection “Obesity” in Frontiers. https://orcid.org/0000-0002-6908-7197

Title：Neuro-metabolic models: unravelling brain influence on metabolic disorders
Abstract：
Due to future restrictions on animal studies, novel in vitro models are necessary, which provide morereliable and accurate results than conventional in vitro cell cultures. In this sense, organ-on-a-chip systems
emulating liver, kidneys, lungs, vessels or even brain functions have been already developed, althoughdifficult to implement as routine analysis systems. One of the main problems is on the difficulty toadequately monitor the conditions and evolution of the model after stimuli. In this sense, the integration ofsensing elements is still one of the main drawbacks due to the complexity of sensing under physiologicalconditions. On the one hand, the integrated sensors suffer from ageing and biofouling, which compromise
their performance and makes necessary continuous recalibration steps. On the other hand, calibration
solutions may compromise cell culture viability and function.
In this talk, several strategies for the development of neuro-metabolic models to study obesity and diabetes
are presented, which based on the compartmentalization of the chip and/or the implementation of newtransduction mechanisms less sensitive to ageing or biofouling.
Speaker： Xavier Muñoz Berbel, PhD
Affiliation：Instituto de Microelectrónica de Barcelona, IMB-CNM (CSIC)
Position：Tenure-track researcher,URL：
http://gtq.imb-cnm.csic.es/en/equipo/xavier-munoz-berbel＜CV＞
I am PhD in biotechnology (2008) and tenure-track researcher at the IMB-CNM (CSIC) from 2020. I
developed unprecedented analytical tools based on microelectronic technologies in Spain (CSIC, Universityof Seville), France (University of Perpignan), U.K. (University of Bath), Denmark (Aarhus University) and The
Netherlands (Groningen University), aiming to resolve important biological questions of clinical interest.
Along my career, I have participated in more than 30 projects from FP7, H2020, HE calls and National calls,
being PI of 14 and coordinator of 10. I am co-author of +70 publications, with +1700 citations (H-index = 24),+20 proceeding and 3 book chapters. I am co-inventor of 15 patents (3 licensed), I have participate in +80
congresses (15 by invitation) and supervised 9 PhDs. I am Associated Editor of the MPDI journal“Diagnostics” and the responsible of the Lab on Chip section.
https://orcid.org/0000-0002-6447-5756