Kawasaki Institute of Industrial Promotion

Innovation Center of NanoMedicine (iCONM)

Annual Activity Report 2022

May 23, 2023
(June 27, 2023 for English Edition)

1

Table of Contents

Prologue・・・・・・・・・・・・・・・・・・・・・・・・・・・・・

3

Overview ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・

4

Major Events ・・・・・・・・・・・・・・・・・・・・・・・・・・

9

Research Promotion & Support ・・・・・・・

18

Epilogue ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・

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iCONM Brochure

CHANGE Brochure21. Prologue
iCONM is located at the King Sky Front, an international strategic cluster in Tonomachi,
Kawasaki City, JAPAN, and started its operation in 2015 as a core institution in this area.
Since its opening, iCONM has served as the operation center of COINS, the Kawasakibase of the Ministry of Education, Culture, Sports, Science and Technology (MEXT)/JST's"COI STREAM" (Center for Innovative Technology and Innovation) program, and we havebeen conducting a great deal of research toward the creation of "In-Body Hospitals" withthe mission of realizing a society in which people become healthy autonomously by
freeing themselves from disease (A Smart Life Care Society).
From FY2022, we have been operating under a newly formulated mid-term businessplan. In this plan, we declare that we will continue to actively develop projects related
to "medical and healthcare fields," "educational fields," and "industrial fields" as a
globally competitive research center and as a core institution of the world's leading
innovation ecosystem. Utilizing this platform, we aim to contribute widely to the citizensof Kawasaki City and to society in general. In October 2022, the project "CHANGE" wasselected by the MEXT/JST for the "Co-Creation Opportunity Formation Support Program(COI-NEXT)" to create tools and systems that enable non-medical professionals, such as
family members, to provide nursing care at home. “CHANGE" has been launched on
October 25, 2022. As the core organization, iCONM is collaborating and co-creating
activities to realize this vision with many experts in related fields.
Now we are pleased to announce the publication of our "Annual Activity Report" as aforum for presenting the results of our research and activities. In addition to this report,
the Center has been disseminating its results in various ways, such as holding academic
seminars and public lectures by researchers and outside experts, planning andorganizing workshops for the general public, and publishing a quarterly newsletter.
We would be more than happy if this report, along with these various efforts, could
contribute to your innovation creation activities in Japan and abroad.
We sincerely appreciate your continued advice and support.

May 2023

Prof. Dr. Kazunori Kataoka
Center Director
Innovation Center of NanoMedicine

32. Overview
OrganizationiCONM's organization consists of a research team to promote research activities, aninnovation promotion team to promote research activities, and an administrative
department to manage the facilities. In addition, each team and department, as well as
external members, are elected to serve on various committees necessary for theoperation of the institute, which deliberate on important matters and establish,
operate, and manage regulations.
Organization Chart（as of March 31, 2023）

4

Current Members in iCONM

Currently, 123 people are employed, including 25 affiliated researchers (including
commissioned researchers), 25 visiting researchers, 41 trainees, 16 staff members
responsible for research support and experimental assistance, and 16 administrative
staff members for research promotion and facility management. The percentage ofwomen is 28%. The percentage of foreign personnel is 20%. Nearly 90 foreign
researchers have conducted research at iCONM and are active worldwide.

Breakdown of researchers working in iCONM（Total 123: Male 89、Female 34, Foreigners 25）

Country of origin of foreign researchers5Country
ThailandInstitution
Chulalongkorn University

People#Period2

8 weeks

1

3 months

Spain

UIC Barcelona

GermanyFriedrich-Schiller University

1

10 weeks

Turkmenistan

Oguzkhan Engineering and2

12 daysTechnologies University
Iceland

University of Iceland

1

1 monthChina

Huazhong University of Science and1

2 years

Technology

New Researchers from Overseas Academic
and Research Institutions in 2022

iCONM Labs

The following 6 labs are working at iCONM:
https://iconm.kawasaki-net.ne.jp/en/laboratory.html① Itaka Lab
Dr. Keiji Itaka, Lab Head/Principal Research Scientist（Institute of
Biomaterials and Bioengineering, Tokyo Medical and Dental
University）
We will commercialize new nucleic acid drugs andbiopharmaceuticals, including mRNA, and promote their applicationin the treatment of intractable diseases and regenerative medicine② Ichiki Lab
Dr. Takanori Ichiki, Research Director/Lab Head/Principal Research
Scientist（Graduate School for Engineering, University of Tokyo）
Dr. Shingo Ueno, Deputy Principal Research Scientist
By integrating nano/micro fabrication technology andbiotechnology, we conduct research and development of devices
and systems that contribute to improving the quality of life (QOL) of
mankind③ Uchida Labs
Dr. Satoshi Uchida, Lab Head / Principal Research Scientist(Medical Research Institute, Tokyo Medical and Dental University)
Dr. Yuki Mochida, Deputy Principal Research Scientist (Medical
Research Institute, Tokyo Medical and Dental University)
6We are engaged in research into every process, from developing ofsystems for the safe and efficient delivery of mRNA to target organs,to vaccines against infectious diseases and cancer, to applications in
the treatment of diseases. Furthermore, in collaboration withcompanies, we are working on the practical application of theseresults④ Kataoka-Kinoh Lab
Dr. Kazunori Kataoka, Center Director / Lab Head/ Principal
Research Scientist (Emeritus Professor, University of Tokyo)
Dr. Hiroaki Kinoh, Deputy Lab Head / Principal Research Scientist
Dr. Shigeto Fukushima, Deputy Principal Research Scientist
Dr. Sabina Quader, Deputy Principal Research Scientist
Dr. Yasutaka Anraku, Deputy Principal Research Scientist (School ofMaterials Science and Engineering, Tokyo Institute of Technology)
We have created supramolecular nanocarriers (polymeric micelles,
polymeric hollow nanocarriers, envelope-type nanocarriers, etc.)
formed by self-assembly of block copolymers and dendrimers(dendritic polymers), and are developing them for clinicalapplications through close medical-engineering-drug collaboration.
⑤ Kimura Lab
Dr. Hiromichi Kimura, Lab Head / Principal Research Scientist（Institute for Future Initiatives, University of Tokyo）
Dr. Tomohiro Anzai, Principal Research Scientist
Dr. Shintaro Sengoku, Principal Research Scientist (School ofEnvironment and Society, Tokyo Institute of Technology)
Toward the realization of smart medicine using In-Body Hospitals,
we will promote management research of open innovation-typeresearch centers, regulatory science research on nanomedicine, andbusiness model research in the field of prevention by industry,
government, and academia, and lead the implementation of suchresearch in society.
⑥ Nishiyama Lab
Dr. Nobuhiro Nishiyama, Lab Head / Principal Research Scientist(Institute of Innovative Research, Tokyo Institute of Technology)
Using precision synthetic polymeric materials as a platform, we areconducting research to construct nanomachines with superintegrated smart functions such as target-directed and stimulus7

responsive functions, and to develop them for targeted therapy,
highly sensitive and precise imaging, and minimally invasive therapy
with less burden to the patient.

Social Collaboration Labs

The following 12 organizations use facilities as social collaboration labs.
https://iconm.kawasaki-net.ne.jp/enterprise_partnership.html① iCONM in Collaboration with BioLabs② AnGes Inc.
③ iXflow Inc.
④ Gene Therapy Research Institution Co., Ltd.
⑤ SBI Pharmaceuticals, Co., Ltd.
⑥ Kao Corporation⑦ NANOEGG Research Laboratories, Inc.
⑧ NanoCareer, Co., Ltd.
⑨ NOF CORPORATION⑩ Nitto Denko Corporation⑪ Braizon Therapeutics, Inc.
⑫ Metcela Inc.

“Magnet Area” located in the center of each of the 2-4 floors. It is
designed as an opportunity to create innovation through cross-culturalcommunications.
83. Major Events in FY2022
New Organization launched on 01-Apr-2022

The COI program adopted by the Ministry of Education, Culture, Sports, Science andTechnology (MEXT) in 2013 expired on March 31 of this year, and the new organization
was launched, resulting in the following new structure as of April 1, 2022.

“Engineering Innovation for Nursing People (Kan-Min-Kogaku)” launchedon 12-Apr-2022

On June 3, the Working Environment Improvement Committee of the Kawasaki City Nursing
Association held a regular meeting at iCONM, and a common understanding was formed
regarding the importance of responding to the needs of the nursing field with the knowledge,
technology, and know-how of science and engineering, and activities for "Engineering Innovation
for Nursing People (Kan-Min-Kogaku)" were launched. The term "Kan-Min-Kogaku" is a coined
word that means "nursing" in the sense of "looking after people" rather than "looking after thesick", and it refers to efforts to reform the way nurses work by combining nursing techniques,
which are mainly performed by human hands, with engineering methods, and to expand these
efforts to realize a society where people can live with peace of mind.
See: https://kawasaki-sanshinkaikan.jp/gyoumu/jyouhou/report/2022-06.html

9Collaboration Agreement with Universitat Internacional de Catalunya(UIC-Barcelona) in Spain was made on 25-Apr-2022.

iCONM has signed a Memorandum of Understanding (MOU) with the Universitat Internacionalde Catalunya (UIC-Barcelona), Spain, with the aim of accelerating exchanges between the two
institutions. iCONM's Dr. Sabina Quader (Deputy Principal Research Scientist) and UICBarcelona's Associate Professor Dr. Rosalía Rodríguez-Rodríguez have been collaborating on
bilateral exchange projects (JSPS - AMED projects), and are currently working together on the
research and development of nanomedicines that can selectively be taken up in the brain andimprove obesity by suppressing lipid metabolism in peripheral tissues. This agreement wasreached in order to accelerate international exchange between the two institutes and tocontinue their strong collaboration.

10

Shared-lab business in collaboration with BioLabs, Inc. was launched on
6-Jun-2022

The Kawasaki Institute of Industrial Promotion (KIIP) agreed to collaborate with BioLabs(Boston, MA, USA), a company with 14 shared-lab operations in Europe and the U.S.,
on a shared-lab business within the iCONM facility. Dr. Fruehauf CEO attended the
ceremony held on June 6 and expressed his enthusiasm, saying, "Together, we want tobe a magnet for science in the world here in Kawasaki.
See: Web of iCONM in Collaboration with BioLabs
https://iconm-service.kawasaki-net.ne.jp/

Innovation Net Award 2022 was presented by the Minister of METI on
14-Jun-2022

iCONM received the Minister of Economy, Trade and Industry Award in the 11th
Regional Industry Support Program Awards (Innovation Net Award 2022) for theactivities of Project COINS, which iCONM implemented as a core center from FY2013 toFY2021. This award is given to the most outstanding initiatives that produce leading
and concrete results that lead to the creation of new businesses and new industries
that take advantage of regional resources and characteristics.

11Dr. Dirisala granted for Interstellar Initiative on 28-Jul-2022

iCONM's Dr. Anjaneyulu Dirisala (Senior Scientist) has been granted as a member of "TheInterstellar Initiative" for FY2022. This is a joint international program between the Japan
Agency for Medical Research and Development (AMED) in Japan and the New York
Academy of Sciences (NYAS) in the United States, which aims to connect young, earlycareer researchers with leading scientists, foster international and interdisciplinary
collaboration, and promote the advancement of science. The program aims to promote
the advancement of science by connecting young, early-career scientists with leading
scientists and fostering international and interdisciplinary collaboration. Youngresearchers selected from around the world will work through workshops and otherevents to address issues in the field of basic research to elucidate the complex
mechanisms of living organisms. Research topics range across all levels of the biologicalsciences, including genes and individual molecules, intracellular networks, intercellularconnections in tissues and organs, and networks that support the complex functions of
the whole organism.

Homepage of NYAS

Dr. Anjaneyulu Dirisala

12Adopted by Ministry of Education, Culture, Sports, Science andTechnology/JST "COI-NEXT Program" on 25-Oct-2022

Kawasaki Institute of Industrial Promotion (KIIP) was granted as the representative
organization of the "Center of Healthy longevity and Nursing innovation with Global
Ecosystem (CHANGE)" which is operated by the Innovation Center of NanoMedicine(iCONM) at the Tonomachi King Skyfront.
Cluster Overview

See︓https://change.kawasaki-net.ne.jp/

Prof. Dr. Kazunori Kataoka was awarded as a Highly Cited Researcher in
2022

Clarivate, a UK-based provider of knowledge and analysis that accelerates innovation,
has announced its Highly Cited Researchers™ for 2022, and Prof. Dr. Kazunori Kataoka,
Center Director of iCONM) has been selected as one of them. This is the seventh timein six consecutive years that Prof. Kataoka has been selected.
https://www.webofscience.com/wos/author/record/1839962

Furthermore, in the first ranking of top scientists in the field of chemistry based ondata collected from Microsoft Academic Graph on December 6, 2021, Dr. Kazunori
Kataoka was ranked 2nd in Japan and 43rd in the world, and was awarded theChemistry in Japan Leader Award. The rankings are based on the D-index (Discipline H13

index) of scientists and take into account the number of publications and citations, andare a highly reliable list based on an in-depth survey of 166,880 scientists registered in
Microsoft Academic Graph. The list is based on an in-depth survey of 166,880 scientists
registered in Microsoft Academic Graph. In the field of chemistry, more than 35,760
profiles were examined. The list also includes the Best Scientist Award and theMaterials Science in Japan Leader Award.
https://research.com/scientists-rankings/chemistry

Announced the name of the COI-NEXT Kawasaki site as "Project
CHANGE” on 21-Dec-2022

The project name, CHANGE (Center of Health longevity And Nursing innovation with
Global Ecosystem), was chosen to unify the center's organization and increase its
visibility in society. The logo, with apricot orange and marine blue as its basic colors, waswidely publicized as the flagship of the Center. The marine blue color suggests that thenursing field, which until now has had little to do with engineering innovation,corresponds to a "blue ocean" in terms of business strategy, and the apricot orange
symbolizes the expansion of opportunity (CHANCE) like the rising morning sun. The "T"
is an engineering motif reminiscent of screws or wrenches, and is superimposed on the"T" to express the desire to change people and society (CHANGE). By displaying thisbanner, all project members can share the objectives and thoughts of the project andmove forward in step with each other.

We view social issues as a CHANCE for innovation creation and industrialization.
We will bring CHANGE to society with our superior Technology and Talent, as well as
Tolerability and Thoughtfulness toward diversity.
In parallel with the renewal of the iCONM brochure, the Project CHANGE brochure has
been prepared in Japanese and English. It can be downloaded from the following website14https://change.kawasaki-net.ne.jp/news/309/

Prof. Dr. Kazunori Kataoka received Biomaterials Global Impact Awards
2023 on 12-Jan-2023

An international journal “Biomaterials” announced that the Biomaterials Global Impact
Prize 2023 will be awarded to iCONM Director Kazunori Kataoka. The first recipient of
the award, now in its third year, is Dr. Robert Langer, one of the highest-ranking
professors at the Massachusetts Institute of Technology, a bioengineer with an annual
research budget of $10 million and more than 100 researchers; the second recipient is achemical and biomedical engineer with a background in nanoscale, macromolecular
processing, and drug and protein transport physics. The second recipient is Dr. Nicholas
Peppas, a chemical and biomedical engineer and professor at the University of Texas who
has provided a sophisticated foundation in the physics and mathematics of scale,macromolecular processes, and drug and protein transport, resulting in numerous
biomedical products or devices. Dr. Kataoka is the first non-U.S. researcher to receive theaward.

Prof. K. Kataoka (4th from Left) and Award Judging Committee Members

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The 1st General Meeting of CHANGE was held on 27-Jan-2023.
The first general meeting was held with the aim of deepening the unity of the project
team. The meeting was intended primarily to allow all participating organizations to
speak, to get acquainted with each other, and to facilitate communication in the future.
Following the presentation of specific research policies by each theme leader, a panel
discussion was held to foster a better understanding of the current state of the nursing
field, which is the core of this project.

Panel Discussion for understanding

In total, 124 people joined the meeting.

nursing jobs.

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The 1st Symposium of CHANGE was held on 27-Mar-2023.
The kick-off symposium, the first external event of Project CHANGE, was held at theStation Conference Kawasaki with the theme "Medical Engineering and Nursing CoCreation Leading to the Realization of a Resilient, Healthy and Longevity Society. A totalof 257 people from various fields attended the symposium, which was open to both onsite and online participation. The symposium introduced Project CHANGE and theresearch being undertaken in R&D theme groups 1 through 5. In addition, high school
students and new nurses who have just started their careers were positioned as the
Future Opinion Board (FOB). They were asked to give their honest opinions about their
future lives in society 20 to 30 years after CHANGE. (For details, please refer to the May
2023 issue of Sangyo Joho Kawasaki.

Prior to the symposium, a workshop with 25 new nurses in their first year of employment
in Kawasaki City and CHANGE members was held on February 3 (photo below, left). A
workshop with 37 second-year students of the Science Department of Kawasaki City
High School for Science and Technology was held on March 7 (photo below, right). The
challenges of an aging society with a declining birthrate are not far off in the future, andmany compliments were paid to the students, who seriously considered these issues as
their own concerns and expressed their will to "change the future", as they said at the
symposium.

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４．Activities in Research Promotion and Support
The iCONM Innovation Promotion Team facilitates Diversity & Inclusion Management at
iCONM, a highly diverse open innovation organization, for creating innovation throughchemical reactions resulting from a cross-cultural exchange. Following the concept of“Design Thinking”, the team also strives to disseminate information and collect opinionsfrom the public and industry, and holds public lectures, academic seminars, and public
events to prevent the gap between research content and societal needs from widening,
In addition, we also hold classes and extracurricular seminars for elementary, junior high,and high school students to foster the next generation of human resources and prepare
for a smooth future handover.
Innovation Promotion Team:Led by three experienced senior managers from pharmaceutical companies, the grouptrains four young staff members in intellectual property, communications, and projectplanning. In addition, a research support group led by a staff member qualified as aveterinarian manages not only the animal experiment facility but also various special
research facilities, ensuring proper use by researchers regarding research ethics andanimal ethics, as well as maintaining research equipment in optimal condition to obtainaccurate research data.
Activities in 2022

① Media Coverage
Number of Coverage: 243
The list is available from the following link:
https://iconm.kawasaki-net.ne.jp/en/activities_press2022.html② Public Lectures“Design your future by learning from the experiences of our seniors” on
30-Jul-2022
https://iconm.kawasaki-net.ne.jp/pdf/iconmlecture4.pdf“Diabetes Care and Support - If a family member is told they havediabetes?” on 10-Dec-2022
https://iconm.kawasaki-net.ne.jp/pdf/iconmlecture5.pdf③ Academic Seminars“Issues on Vaccination for COVID-19 Infection” on 3-Jun-2022
Prof. Noboru Sakamoto, President of Kawasaki City College of Nursing
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar1.pdf
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“Proposal of On-Chip Molecular Evolution Screening System for
Creation of Functional Proteins” on 24-Jun-2022
Dr. Shingo Ueno, Deputy Principal Research Scientist of iCONM
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar2.pdf“Creation of Bio-Attachable Electronics and its Application to Medicaland Health Care” on 19-Jul-2022
Prof. Toshinobu Fujieda, Associate Professor of Tokyo Institute ofTechnology
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar3.pdf“Fundamental Technologies and Future Prospects for mRNA Vaccines”
on 12-Sep-2022
Prof. Satoshi Uchida, Professor of Tokyo Medical and Dental University
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar4.pdf“Development of Nucleic Acid Drug Delivery Targeting Targets Other
Than the Liver and Development Toward Muscle Tissue Delivery” on
28-Sep-2022
Prof. Mizuki Naito, Assistant Professor of the University of Tokyo
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar5.pdf“Selective synthesis of chitosan nano-conjugates for photochemicalinternalization cancer therapy” on 30-Nov-2022
Prof. Már Másson, Professor of the University of Iceland
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar6.pdf“New Aspects of Pharmacokinetic Research Accelerating in the Eraof Novel Medical Modalities - Interfaces with Cutting-Edge
Technologies to Visualize the Black Box in the Body-“ on 16-Dec2022
Dr. Hideki Hirabayashi, Director of the Pharmacokinetics ResearchInstitute, Takeda Pharmaceuticals.
https://iconm.kawasaki-net.ne.jp/pdf/academic-seminar7.pdf④ Public Event

KSF Summer Science Event 2022 on 10-Aug-2022.
https://iconm.kawasaki-net.ne.jp/news20220826-2.html

Public Event at Kawasaki Municipal Science Museum on every
weekend of November 2022.
https://iconm.kawasaki-net.ne.jp/news20221003.html
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Workshop with New Nurses on 3-Feb-2023.

The Kawasaki Nursing Association hosted a workshop for 25 newnurses. Project CHANGE members joined each working group to discuss
the theme of "what we wish we had" in the nursing field.
Workshop with High-School Students on Aging Society on 7Mar-2023
https://change.kawasaki-net.ne.jp/news/267/
Extracurricular support for elementary, junior high and highschools

In FY2022, we accepted visits from the following 9 schools to answer
the following questions: What is medicine? What is research ondelivering medicines to affected areas and its significance, and what is a
research institute that conducts such research? We provided classes
tailored to the level of each school.
5/26

Kariyado Elementary School, Kawasaki
99 students of the 4th year
5/31
Higashi Ogura Elementary School, Kawasaki
126 students of the 3rd year
6/29
Nago Commercial and Technical High School, Okinawa
45 students of the 2nd year
7/22
Kawasaki City High School for Science and Technology
41 students of the 2nd year
8/17
Shizuoka Prefectural Haibara High School, Shizuoka
42 students of the 1st year
9/08
Morioka City Joto Junior High School, Iwate
56 students of the 3rd year
9/15
Isezaki City Yotsuba Gakuen High School, Gunma
30 students of the 2nd year
10/26
Kawasaki City Kawasaki High School
60 students of the 1st year
3/09
The Junior High School belonging to Kawasaki City
Kawasaki High School
125 students of the 2nd year
In total, 624 students visited iCONM in FY2022.
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⑤ Production of Talent from iCONM

Dr. Joachim van Guyse / Assistant Professor / University of Leiden
29-Jul-2022
https://iconm.kawasaki-net.ne.jp/news20220729.html

Dr. Saed Abbasi / Post-Doctoral Fellow / Johns-Hopkins University
9-Aug-2022
https://iconm.kawasaki-net.ne.jp/news20220809.html

Dr. Junjie Li / Associate Professor / Kyushu University
16-Aug-2022

https://iconm.kawasaki-net.ne.jp/news20220816.html

Dr. Daniel Gonzalez-Carter / Senior Researcher/ Institute for
Bioengineering of Catalonia
6-Sep-2022
https://iconm.kawasaki-net.ne.jp/news20220906.html

Dr. West Paraiso / Senior Researcher / Red Arrow Therapeutics Co. Ltd.
21-Sep-2022.
https://iconm.kawasaki-net.ne.jp/news20220921.html⑥ iCONM Kids (Web)The website is aimed primarily at middle and high school students, andaims to increase scientific literacy by providing easy-to-understandexplanations of content related to nanomedicine.
https://iconm.kawasaki-net.ne.jp/kids/⑦ Deliverables

iCONM Brochure (Renewal)
https://iconm.kawasaki-net.ne.jp/pdf/iCONM_pamphlet2023.pdf

Project CHANGE Brochure (1st Edition)

https://change.kawasaki-net.ne.jp/news/309/

iCONM Newsletter (Seasonal Publication)

https://iconm.kawasaki-net.ne.jp/activities_news_letter.html⑧ Cross Cultural Events

10th Cross-Cultural Event on 25-Jul-2022“Let's go for a walk around Barcelona!"
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Mr. Jesus Garcia / Internship from UIC-Barcelona (Spain)
https://iconm.kawasaki-net.ne.jp/news20220725.html

11th Cross-Cultural Event on 5-Sep-2022“Landscapes in the History of the Transfer of the Capital in Japan Focusing on Nara and Kyoto -”Dr. Makoto Shimazaki / Communications Manager of iCONM (Japan)
https://iconm.kawasaki-net.ne.jp/news20220905.html

12th Cross-Cultural Event on 3-Oct-2022“From South to East - Visiting the German cities Freiburg and Jena”
Ms. Natalie Elizabeth Groeppert / Internship from Friedrich-Schiller
University Jena (Germany)
５．Epilogue“Center of Innovation (COI) Program – Kawasaki Cluster” of MEXT/JST,
which had been in place as “COINS” since iCONM's founding, came to an
end in March 2022, and the fiscal year beginning April 2022 is a year of
great change for us. Our goal at COINS of realizing an actual in-bodyhospital by 2045 was maintained, and the modification of nanomachineswith anti-cancer drugs and nucleic acid medicines is still underway. We
have also made it possible to deliver IL-12, which has attracted attention
as a powerful immunotherapeutic agent. However, using IL-12 in clinicalpractice is difficult due to its strong side effects. The new nanomedicine
has made it possible to deliver IL-12 to the active center of cancer, whichchanges over time, in pinpoint accuracy. In October 2022, Project CHANGE
was granted by MEXT/JST as a "Support Program for Forming a Place for
Co-Creation". CHANGE aims to expand the scope of activities into thenursing field, which has been unfamiliar to the public, and to realize asociety where testing and diagnosis can be easily performed even at home.
Here, we will fully utilize our experience and expertise in research support
accumulated through COINS to confront the challenges of an aging society
with an increasingly serious declining birthrate, and to innovate testingand diagnostic technologies essential for the realization of In-Body
Hospitals.
Gathering input from citizens and product users is important for bothtypes of research, especially for long-term projects that require training
successors and ensuring a baton zone of sufficient distance. We willcontinue to support extracurricular classes at elementary, junior high, and22

senior high schools, as well as workshops and citizen exchange events withhigh school students and young nurses, to conduct research anddevelopment with public people. We would also like to contribute toeconomic growth by promptly implementing the results obtained insociety and generating commercialization and industrialization.

References
Publication Record in FY2022
https://iconm.kawasaki-net.ne.jp/activities_research2022.html

Coverage Record in FY2022
https://iconm.kawasaki-net.ne.jp/activities_press2022.html

This edition was issued on June 27, 2023, translated the original Japaneseversion published on May 23, 2023 in English. In case of discrepancies intranslation, the content of the original Japanese version takes precedence.
Editors:
T. Ogata, N. Kuriyama / Department of Administration
K. Nagai, M. Shimazaki / Innovation Promotion Team
Kawasaki Institute of Industrial Promotion / Innovation Center of
NanoMedicine (iCONM)
Special Thanks for Proofreading:
S. Quader / Deputy Principal Research Scientist of iCONM

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