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Nippon Shokuhin Kagaku Kogaku Kaishi Vol. //, No. ++, /.3!//2 (,**2) "

#549

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** 5TTC FE#ects of Jumbo Leek on Blood Glucose Level in Streptozotocin-induced
Diabetic Rats and Liver Damage in Acetaminophen-treated Rats
Ayumi Uchida, Tao Kei*, Jun Ogihara*, Hiroshi Matsufuji*,
Shigenori Ohta** and Hidetoshi Sakurai*
Wadaman Science Co., Ltd., /.0 Karasuma-Oike agaru, Nijoden-cho, Nakagyo-ku, Kyoto 0*.ῌ*2./* Nihon University College of Bioresource Sciences, +200 Kameino, Fujisawa-shi, Kanagawa ,/,ῌ2/+*** TTC Co., Ltd., +ῌ,*ῌ, Ebisunishi, Shibuya-ku, Tokyo +/*ῌ**,+῍῍῍῍῍῍῍῍῍῍῍῍῍῍῍῍To investigate the physiological function of a high content of inulin in jumbo leek, the e#ects offreeze-dried, odorless jumbo leek with an inulin content of 0*ῌ (PSII) on the blood glucose level andbiochemical markers in blood in streptozotocin (STZ)-induced diabetic rats and the liver damage inacetaminophen (AAP)-treated rats were studied. In the ﬁrst experiment, rats were fed PSII for two weeks
following a one-week STZ (0* mg/kg) treatment. Oral glucose tolerance tests (OGTTs) were performed ondays 1 and +.. Biochemical markers in blood were measured on day +.. In the second experiment, rats were
fed PSII for two weeks and then administered AAP (/** mg/kg). After ,. h, liver-damage markers and theactivities of blood aspartate transaminase (AST) and alanine transaminase (ALT) were measured and ahistopathological examination of the liver was performed. In the ﬁrst experiment, the elevation of blood
glucose level in OGTT was suppressed by feeding rats 2.- g PSII (/ g inulin)/kg per day. Among thebiochemical markers, total cholesterol and triglyceride levels rose in STZ-treated rats compared with control
rats. PSII fed to STZ-treated rats lowered these two marker levels below those of the control rats. AST and
ALT activities tended to decrease, suggesting that PSII ameliorated liver damage. In the second experiment,
AST and ALT activities as well as the histopathological examination of liver conﬁrmed that PSII (, g/kg perday) protected rats from liver damage before AAP treatment.
(Received Mar. /, ,**2 ; Accepted Aug. 2, ,**2)
Keywords : acetaminophen, diabetes, garlic, leek, streptozotocin῍ῌ῏ῌ῎ :,**+  G1+1H&IJKLMNOP1+1H

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Ariga, T., Kumagai, H., Yoshikawa, M., Kawakami, H.,

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 
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+, ῎ Allium sativum LINNE Shiro '1234 56
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