Kazuya KANEMOTO
Assistant Professor

Graduate School of Pharmaceutical Sciences, Tohoku University 6-3 Aoba,
Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: kazuya.kanemoto.a1@tohoku.ac.jp
Education2015 ‒ 2018

Ph. D. (Engineering)
Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University(Advisor: Prof. Takamitsu Hosoya, Assoc. Prof. Suguru Yoshida)2009 ‒ 2011

M. Sc. (Engineering)
Graduate School of Engineering, Hokkaido University(Advisor: Prof. Norio Miyaura, Assoc. Prof. Yasunori Yamamoto)2005 ‒ 2009

B. Sc. (Engineering)
Faculty of Engineering, Hokkaido University

2011.8 ‒ 10

Visiting student
Rice University, Department of Chemistry(Prof. Zachary T. Ball)

Professional Experience
2021.3 ‒ Present

Assistant Professor
Graduate School of Pharmaceutical Sciences, Tohoku University

2019.4 ‒ 2021.2

Assistant Professor
Faculty of Science and Engineering, Chuo University

2018.5 ‒ 2019.3

Assistant Professor
Institute of Biomaterials and Bioengineering,Tokyo Medical and Dental University

2011.4 ‒ 2018.4

Researcher
Astellas Pharma Inc.

1

Awards
2020

Meiji Seika Award in Synthetic Organic Chemistry, Japan2017

15th IBB Bio Future Research Encouragement Prize----------------------------------------------------------------------------------------------------------------------------2024○ Kento Tsukiji, Kazuya Kanemoto, Naohiko Yoshikai, Poster Award, 4th Bowei
Research Conference (Taiwan).

2023○Masaki Iwata, Naohiko Yoshikai, Kazuya Kanemoto, セミナー賞, 第 38 回有機合成化学
若手研究者の仙台セミナー．

2023○ Kento Tsukiji, Kazuya Kanemoto, Naohiko Yoshikai, Poster Awards, The 69th

Symposium on Organometallic Chemistry.
2023○ Kento Tsukiji, Kazuya Kanemoto, Naohiko Yoshikai, Excellent Poster Awards,

International Symposium for the 80th Anniversary of the Tohoku Branch of the
Chemical Society of Japan.
2023○ Masaki Iwata, Kazuya Kanemoto, Naohiko Yoshikai, Excellent Poster Awards,

International Symposium for the 80th Anniversary of the Tohoku Branch of the
Chemical Society of Japan.
2023○Tsukiji Kento, Kanemoto Kazuya, Yoshikai Naohiko, Best Poster Award, Tohoku

University GP-Chem Chemistry Summer School 2023.
2022○H. Asanuma, S.-i. Fukuzawa, K. Kanemoto, Journal of Sulfur Chemistry Poster

Award, ISOCS-29 (Canada, Guelph)
2021○H. Machida, K. Kanemoto, S.-i. Fukuzawa, Student Research Competition Winner(2.8%), Pacifichem 2021.
2021○H. Asanuma, T. Watanabe, K. Kanemoto, S.-i. Fukuzawa, Chemical Communication

Poster Prize, Pacifichem 2021.
th

2021

○H. Machida, K. Kanemoto, S.-i. Fukuzawa, Poster Prize, 11 CSJ Chemistry Festa.

2021○H. Asanuma, K. Kanemoto, T. Watanabe, S.-i. Fukuzawa, Poster Prize, 11

th

CSJ

Chemistry Festa.
2021

th

○H. Machida, K. Kanemoto, S.-i. Fukuzawa, Poster Prize, 119 Symposium on Organic

Synthesis.

Grants2024.4 ‒ 2027.3

Kobayashi foundation

2024.4 ‒ 2025.3

The Noguchi Shitagau Research Grant

2023.4 ‒ 2025.3

The Research Foundation for Pharmaceutical Sciences

2023.4 ‒ 2024.3

The NOVARTIS Foundation (Japan) for the Promotion of Science

2022.4 ‒ 2023.3

Takahashi Industrial and Economic Research Foundation

2022.4 ‒ 2024.3

JSPS KAKENHI (Young Scientists)

2022.4 ‒ 2023.3

Uehara memorial Foundation2

2021.4 ‒ 2023.3

Meiji Seika Award in Synthetic Organic Chemistry, Japan

2021.4 ‒ 2022.3

Takahashi Industrial and Economic Research Foundation

2021.4 ‒ 2022.3

Tokyo Biochemical Research Foundation

2020.4 ‒ 2022.3

JSPS KAKENHI (Young Scientists)

2020.4 ‒ 2022.3

Kato Memorial Bioscience Foundation

2019.9 ‒ 2021.3

JSPS KAKENHI (Research Activity Start-up)

3

Original Paper (2024. 3/4)
37

Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles, K.
Kanemoto, K. Yoshimura, K. Ono, W. Ding, S. Ito, N. Yoshikai* Chem. Eur J. (2024).
R’

R nY I

SiMe3

CsF

CF3
CF3

+
OTf

Construction

of

R’

I

IIII

DiverseYRn

YRn

Pyrrolidine-Based

CF3

O

R’

Y = N or O
facile preparation

36

F3C

N–I(III) and O–I(III)as N/O nucleophileO

diversely transformable

Skeletons

throughAg-

Catalyzed

Stereoselective Addition‒Elimination Reaction of Azomethine Ylides with Nitroallyl
Acetates, I. Ohno, K. Kanemoto*, S. Furuya, Y. Suzuki, S.-i. Fukuzawa,* Org. Lett. DOI:
10.1021/acs.orglett.4c00184.
Stereoselective addition–elimination reaction

Diverse skeletones
R1

R1

CO2Me

N

R2

O2N

cat. Ag(R, Sp)-TCF

NO2

R1

5

CO2Me
R2
NO2
R2

R2
*
CO
N *
2Me

R1

OAc
! Vicinal stereocenter (diastereo/enantioselective)! Tetrasubstituted carbon! Transformable functional groups

35

5
N

R1

5
N
H

Me

5

NH
O

R2

NO2

5
6

N

N

O

R3

N-Terminal-Specific Dual Modification of Peptides through Copper-Catalyzed [3+2]Cycloaddition, H. Machida, K. Kanemoto,* Angew. Chem. e202320012, (2024).

34

N-Terminal-Specific Dual Modification of Peptides through Copper-Catalyzed [3+2]Cycloaddition, H. Machida, K. Kanemoto,* Angew. Chem. Int. Ed. e202320012, (2024).
プ レ ス リ リ ー ス ： https://www.tohoku.ac.jp/japanese/2024/02/press20240213-02Peptides.html
日経新聞： https://www.nikkei.com/article/DGXZRSP668321̲T10C24A2000000/
N-Terminal-specific dual modification of peptides
ε-amine

H 2N

N-terminus

O

O

4

2)

N

4

H
N

O

N
H

O
cat. Cu

NH2

O

N

H

NH2
H
N

untouched

O

1)

O

Modified(cycloaddition)

4

Me

O

NH2
4

N

O
p-Tol

H 2N
4

NH
H 2N

4

✔ Robust C–C bond formation✔ High yield and exo-selectivity✔ Flexible design of reagents

33

CarboiodanationofArynes:Organoiodine(III)+Compoundsas

Nucleophilic+

Organometalloids, C. Arakawa, K. Kanemoto, K. Nakai, C. Wang, S. Morohashi, E. Kwon,+

S. Ito, N. Yoshikai,* J. Am. Chem. Soc. 146, 3910-3919 (2024). Equal contribution.

novel reaction
mode of R–I(III)
R

SiMe3

I

O

CsF

CF3
CF3

+
OTf

R δ–

δ+

CF3

O
δ+
IIII

δ–

diverse R group:
alkynylalkenyl(hetero)aryl

32

F3C

I
R
versatile arenebuilding blocks

Stereoselective Hydroxyallylation of Cyclopropenes with Cyclopropanols via NHC
Catalysis of Transient Organozinc Species, K. Tsukiji, A. Matsumoto, K. Kanemoto,* N.
Yoshikai,* ChemRxiv, DOI: 10.26434/chemrxiv-2023-hch07-v2.

31

Amination

N-(Organodithio)phthalimides

of

for

the

ModularSynthesisofAminodisulfides, H. Asanuma, K. Kanemoto,* Org. Lett. 26, 438-443, (2024).

Selected as Front CoverR

Phthal

S

S

Mor

N

HS
PhthalS

O

Phthal

R

S

R

S

R3
NH
R2

R3

N

S

R

S

R2
variousaminodisulfidesOdithiophthalimide
Readily available✔ Stable and readily availability of N-dithiophthalimide✔ Widely applicable modular synthesis✔ Flexible combination of C–S/S–N, S–S/S–N, and S–N/S–N bond formations

30

Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles, K.
Kanemoto, K. Yoshimura, K. Ono, W. Ding, S. Ito, N. Yoshikai,* ChemRxiv, DOI:
10.26434/chemrxiv-2023-kzh7p.

29

Dipolarophile-Steered Formal Stereodivergent Synthesis of 2,5-cis/trans-Pyrrolidines
Based on Asymmetric 1,3-Dipolar Cycloaddition of Imino Lactones, S. Furuya, K. Muroi,
K. Kanemoto, S.-i. Fukuzawa, Chem. Eur. J. e202302609, (2023).

5

28

Carboiodanationofarynes:Organoiodine(III)+compounds

asnucleophilic+organometalloids, C. Arakawa, K. Kanemoto, K. Nakai, C. Wang, S. Morohashi, E. Kwon,+

S. Ito, N. Yoshikai, 10.26434/chemrxiv-2023-knrnb-v2. Equal contribution.
27

Cationic Iridium-Catalyzed Decarboxylation of Aromatic Carboxylic Acids, R. Nonami, Y.
Kishino, T. Yamasaki, K. Kanemoto, K. Iwai, N. Nishiwaki, K. Shibatomi, T. Shirai, Chem.

Asian J. e202300533, (2023).
26

Zinc-MediatedDiastereoselective

Annulationof

Cyclopropanols

withAlkylidenemalononitriles via Enolized Homoenolate, K. Tsukiji, T. Hayakawa, K. Kanemoto,
N. Yoshikai,* Asian J. Org. Chem. 12, e202300114, (2023).
25

N-Terminal-selective Cu-catalyzed [3+2] cycloaddition for irreversible assembly of two
modules with a peptide, H. Machida, K. Kanemoto,* H. Fuwa, 10.26434/chemrxiv-2023sxw2w.
N-terminal-specific three component conjugation
1)

H
N

H 2N
O

N-terminal

Principle of N-terminal selectivity

O

NH2
4

N
H

R1

O

R2

O

cat. Cu

24

H
N

O

N

No ylide formationazomethine ylide○N-terminal

4

O

2)

NH2

O

N

H

M

ü Robust C–C bond formation
ü High yield and diastereoselectivity
ü Flexible design of reagentsH
N

N× Internal peptide

×ε-Amine of lysine
H 2N

O

O

or

N
H

H
N
O

N-(Morpholine-4-dithio)phthalimide: A Shelf-Stable, Bilateral Platform Molecule Enabling
Access to Diverse Unsymmetrical Disulfides, H. Asanuma, K. Kanemoto,* T. Watanabe,
S.-i. Fukuzawa, Angew. Chem. 135, e202219156, (2023).

23

N-(Morpholine-4-dithio)phthalimide: A Shelf-Stable, Bilateral Platform Molecule Enabling
Access to Diverse Unsymmetrical Disulfides, H. Asanuma, K. Kanemoto,* T. Watanabe,
S.-i. Fukuzawa, Angew. Chem., Int. Ed. 62, e202219156, (2023).
New disulfide platform

Divergent transformation of platform molecule

O

S N
O
imide
without [H+]

22

O

R1

N S
O

amino
vs with [H+]

N
with
[H+]

O

R2
S
S

R1

R2

S

S R1
without+[H ]Diverse disulfides

N-(N-Morpholindithio)phthalimide: A Shelf-Stable, Bilateral Platform Molecule forAccessing Diverse Unsymmetrical Disulfides, H. Asanuma, K. Kanemoto,* T. Watanabe,
S.-i. Fukuzawa, 10.26434/chemrxiv-2022-t1xn4

6

21

Chiral Silver Complex-Catalyzed Asymmetric Conjugate Addition of 1-Pyrroline-5Carbonitrile to α-Enones, H. Araki, S. Furuya, K. Kanemoto, S.-i. Fukuzawa, J. org.

Chem. 88, 924-932, (2023).
20

Diastereoselective Conversion of Cyclopropanols to Cyclopentane-1,3-diols via Aldol
Dimerization of Zinc Homoenolates, K. Tsukiji, Y. Sekiguchi, K. Kanemoto, N. Yoshikai,

Chem. Lett. 51, 1012-1014, (2022).
19

exoʹ-Selective Construction of Dispiropyrrolidines by the Silver-catalyzed Asymmetric[3+2] Cycloaddition of Imino Esters with 4-Benzylidene-2,3-dioxopyrrolidines, S. Furuya,
K. Kanemoto,* S.-i. Fukuzawa,* Chem. Asian J. 17, e202200239, (2022).

exoʹ-Selective Construction of Spirobipyrrolidines by 1,3-Dipolar Cycloaddition
O

Ar2
Ar1

N

cat. Ag / L*

CO2Me
N
Bn

O

2

4

HN 5

O

R
N

via
O

O
N

*LAgⅠ

Bn

Ar1

ü Excellent diastereo (exoʹ)- and enantioselectivity
ü Wide substrate scopeü Machanistic study

18

MeO2C

Ar2

exoʹ-cycloadducts
unusal stereochemistryin 1,3-DC reaction

Michael adduct
Ar2

O

N
Ar1
bond rotation O
before Mannich

OMeMichael / Mannich Pathway
with bond rotation

Synthesis and Evaluation of Novel Planar-Chiral Monophosphine Ligands Bearing
Ferrocene-Triazole Backbones, S. Sakai, K. Kanemoto,* S.-i. Fukuzawa,* Eur. J.

Inorg .Chem., 6, e202100967, (2022).
Novel planar chiral biaryl monophosphine ligands
R2
Fe

Me
NMe2

(S)-Ugi's amine

17

N N
Fe

N

N N

R1

NMe2

R2

R 32P

Fe

N

R1

R1

ü Ferrocene-triazole backbone
ü Easy to accessü High catalytic activity
ü Moderate enantioselectivity(Suzuki-Miyaura reaction)

Cationic Iridium-Catalyzed Asymmetric Decarbonylative Aryl Addition of Aromatic
Aldehydes to Bicyclic Alkenes, R. Nonami, Y. Morimoto, K. Kanemoto, Y. Yamamoto, T.
Shirai,* Chem. Eur. J., 28, e202200317, (2022).
【Selected as supplementary cover】【Selected as hot paper】

16

Synthesis and properties of 5,5ʼ-diethynyl indigos and their polymers using Glaser
coupling reaction, S. Kenmochi, K. Kanemoto, T. Ikeda, S.-i. Fukuzawa, Fac. Sci. Eng.,

Chuo Univ. 27, 35-46, (2022).

7

15

Trifluoroacetic Acid-Mediated Desulfurilative Sulfonylation of Activated Olefins Using
Potassium p-Toluenethiosulfonate, T. Watanebe, K. Kanemoto,* S.-i. Fukuzawa, Bull.

Fac. Sci. Eng., Chuo Univ., 27, 15-33, (2022).
14

Silver/ThioClickFerrophos-Catalyzed 1,3-Dipolar Cycloaddition and Tandem AdditionElimination Reaction of Morita‒Baylis‒Hillman Adducts, Y. Suzuki, K. Kanemoto,* A.
Inoue, K. Imae, S.-i. Fukuzawa,* J. Org. Chem., 86, 14586-14596, (2021).

13

Copper-Catalyzed Single C‒H Amination of 8-Aminoquinoline-Directed Ferrocenes, K.
Kanemoto,* N. Horikawa, S. Hoshino, Y. Tokoro, S.-i. Fukuzawa,* Org. Lett., 23, 4966‒

4970, (2021).【Selected as supplementary cover】

12

Palladium-Catalyzed Sulfinylation of Aryl- and Alkenylborons with Sulfinate Esters, M.
Suzuki, K. Kanemoto, Y. Nakamura, T. Hosoya, S. Yoshida,* Org. Lett., 23, 3793‒3797,(2021).

11

Acid-Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino
Dithiosulfonate, K. Kanemoto,* K. Furuhashi, Y. Morita, T. Komatsu, S.-i. Fukuzawa,* Org.

Lett., 23, 1582‒1587, (2021).
【

Highlighted

in

Organic

Chemistry

chemistry.org/abstracts/lit7/808.shtm)】【Selected as supplementary cover】

8

Portal(https://www.organic-

10

Copper-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Imino Esters to Unsaturated
Sultones, S. Furuya, K. Kanemoto,* S.-i. Fukuzawa,* J. Org. Chem., 85, 8142‒8148,(2020).
【Highlighted in Synfacts (H. Yamamoto, T. Hattori, Synfacts, 16, 1118, (2020).)】【Selected as supplementary cover】

9

Cationic Iridium/Chiral Bisphosphine-Catalyzed Enantioselective Hydroacylation of
Ketones, T. Shirai,* T. Iwasaki, K. Kanemoto, Y. Yamamoto, Chem. Asian J. 15, 18581862, (2020).

8Functionalization of a Single C‒F Bond of Trifluoromethylarenes Assisted by an orthoSilyl Group Using a Trityl-Based All-in-One Reagent with Ytterbium Triflate Catalyst, Y.
Kim, K. Kanemoto, K. Shimomori, T. Hosoya, S. Yoshida,* Chem. Eur. J. 26, 6136-6140,(2020).

7

Synthesis of Phenoxathiins and Phenothiazines by Aryne Reactions with Thiosulfonates,
K. Kanemoto, Y. Sakata, T. Hosoya, S. Yoshida,* Chem. Lett., 49, 593-596, (2020).

9

6Synthesis of Alkynyl Sulfides by Copper-Catalyzed Thiolation of Terminal Alkynes Using
Thiosulfonates, K. Kanemoto, S. Yoshida,* T. Hosoya,* Org. Lett., 21, 3172-3177, (2019).
【Press Release (https://www.tmd.ac.jp/archive-tmdu/kouhou/20190423̲1.pdf)】【Most downloaded article of Org. Lett. in April 2019】【

Highlighted

in

Organic

Chemistry

Portal(https://www.organic-

chemistry.org/abstracts/lit6/827.shtm)】

5

Copper-Catalyzed Regio- and Diastereoselective 1,3-Dipolar Cycloaddition Reactions of
Glycine Imino Esters with 1-Propene-1,3-sultone, S. Furuya, S. Kato, K. Kanemoto, S.-i.
Fukuzawa,* Eur. J. Org. Chem. 4561-4565, (2019).

4

Facile Synthesis of Diverse o-Iodoaryl Triflates from o-Silylaryl Triflates by Aluminummediated Desilyliodination, S. Yoshida,* Y. Hazama, K. Kanemoto, Y. Nakamura, T.
Hosoya,* Chem. Lett., 48, 742-745, (2019).

3

Modular Synthesis of Unsymmetrical Doubly-ring-fused Benzene Derivatives Based ona Sequential Ring Construction Strategy Using Oxadiazinones as a Platform Molecule,
T. Meguro, S. Chen, K. Kanemoto, S. Yoshida,* T. Hosoya,* Chem. Lett., 48, 582-585,(2019).

2

Modified Conditions for Copper-catalyzed ipso-Thiolation of Arylboronic Acid Esters
with Thiosulfonates, K. Kanemoto, S. Yoshida,* T. Hosoya,* Chem. Lett., 47, 85-88,(2018).

10

1

Rhodium-catalyzed odorless synthesis of diaryl sulfides from borylarenes and S-aryl
thiosulfonates, K. Kanemoto, Y. Sugimura, S. Shimizu, S. Yoshida,* T. Hosoya,* Chem.

Commun., 53, 10640-10643, (2017). 【Selected as inside back cover】

11