AUSTRALIANPHENOMICS.ORG.AU@PHENOMICS#AMMRA2019

February 20-21, Melbourne, Australia

2019 AMMRA& AMPC Meeting

PROGRAM - DAY 1
W E D N E S D AY F E B R U A R Y 2 0 T H
1130-1220

REGISTRATIONS & LUNCH

1220-1230

MEETING WELCOMES E S S I O N 1 : T E C H N O L O G I C A L A D VA N C E S
1230-1300

THE IMPC: TOWARDS DECIPHERING THE FUNCTION OF
HUMAN GENETIC VARIATION
Steve Brown (MRC Harwell, UK; IMPC)

1300-1330

WALKING BEFORE RUNNING: INBRED MOUSE DATA FOR LEARNING TO ANALYSE HUMAN
GENOMIC VARIATIONDan Andrews (Australian National University, Canberra)

1330-1400

INTRODUCING IN VIVO MOLECULAR IMAGING FOR MOUSE PHENOTYPE
Ho-Young Lee (Seoul National University, South Korea)

1400-1430

MOUSE BRAIN PHENOTYPING USING ULTRA-HIGH FIELD MRI AND SIMULTANEOUS MR/PETIMAGING
Nyoman Kurniawan (University of Queensland, Brisbane)

1430-1500

DECIPHERING NOVEL NONCODING RNA GENES IN MOUSE GENOME
Yong Tian (Institute of Biophysics, Chinese Academy of Sciences, China)

AFTERNOON TEA
1530-1600

GENERATION OF MOUSE MODELS AT THE AUSTRALIAN PHENOMICS NETWORK FROMINTERNATIONAL ES CELL RESOURCES AND BY THE APPLICATION OF CRISPR-BASEDAPPROACHES
Ian Smyth (Monash University, Melbourne)

1600-1630

FINDING CRITICAL CANCER DRIVING GENES USING FUNCTIONAL GENOMICS SCREENING
IN VIVO
Marco Herold (WEHI, Melbourne)

1630-1700

SINGLE CELL GENOMICS AND SYSTEMS BIOLOGY: DEFINING THE IDENTITY AND
DYNAMICS OF ADULT GASTRIC ISTHMUS STEM CELLS
Jong Kyoung Kim (DGIST, South Korea)

1700-1730

GENE-ENVIRONMENT INTERACTIONS: EFFECTS OF HIGH FRUCTOSE CONSUMPTION ON BODYWEIGHT GAIN IN MICE WITH DIFFERENT LEVELS OF STRESS: ASSOCIATION WITH CHANGES IN
PRO-INFLAMMATORY CYTOKINES AND GUT MICROBIOTA
Chao-Kuen Lai (Taiwan Mouse Clinic, Taiwan)

1730-1800

AMMRA DIRECTORS’ BUSINESS MEETING(attendance by invitation)

1730-1830

POSTER SESSION

1900

CONFERENCE DINNER, UNIVERSITY HOUSE, THE UNIVERSITY OF
MELBOURNE

PROGRAM - DAY 2T H U R S D AY F E B R U A R Y 2 1 S T
S E S S I O N 2 : A N N U A L M E M B E R P R O G R E S S R E P O R T S A N D S TAT U S U P D AT E S
0900-0920

AMMRA HOMEPAGE AND DATA INTEGRATION IN RIKEN BIORESOURCE RESEARCH CENTER
Hiroshi Masuya (RIKEN, Japan)
PROGRESS REPORT OF MOUSE RESOURCES AT RIKEN BIORESOURCE RESEARCH CENTER
Atsushi Yoshiki (RIKEN, Japan)
UPDATES ON MUTANT MOUSE CREATION IN RIKEN BRC
Shinya Ayabe (RIKEN, Japan)
THE CURRENT STATUS OF PHENOTYPING PIPELINE IN RIKEN BRC
Masaru Tamura (RIKEN. Japan)

0920-0930

OPERATIONAL STATUS OF THE AUSTRALIAN PHENOMICS NETWORK
Michael Dobbie (Australian Phenomics Network, Canberra)

0930-0940

NLAC, NARLABS, A MULTIDISCIPLINARY BIOMEDICAL PLATFORM FOR ACADEMIC AND INDUSTRIAL
NEEDS
Meng-Chun Monica Shih (National Laboratory Animal Center, Taiwan)

0940-0950

PROGRESS REPORT OF CARD, JAPANToru Takeo, (Center for Animal Resources and Development, Japan)

0950-1000

THE KOREA MOUSE PHENOTYPING CENTER (KPMC)
Je Kyung Seong (Seoul National University/KPMC, South Korea)

1000-1010

THE TAIWAN MOUSE CLINIC
Chao-Kuen Lai (Taiwan Mouse Clinic, Taiwan)

1010-1020

THE MODEL ANIMAL RESEARCH CENTER (MARC), CHINA(TBC)

1020-1030

LABORATORY ANIMAL RESOURCE CENTER (LARC), KOREA(TBC)

1030-1040

DESIGNED ANIMAL RESOURCE CENTRE (DARC), KOREA(TBC)

MORNING TEASESSION 3: RESEARCH APPROACHES AND DISCOVERIES
1100-1130

A MOUSE STRAIN FOR EVERY GENE, A PATHOLOGY FOR EVERY STRAIN?
SYSTEMATIC PATHOLOGY PHENOTYPING TO IDENTIFY THE
MORPHOLOGICAL BASIS OF PHENOTYPES
Colin McKerlie (Center for Phenogenomics, Canada)

1130-1200

EPIGENETICS(TBC)

1200-1230

FECAL MICROBIOTA TRANSPLANTATION (FMT) FROM ANAEROBICEXERCISED RATS IMPROVED METABOLIC PHENOTYPE IN TYPE 2
DIABETIC MODEL, ZDF RATS
Je Kyung Seong (Seoul National University, South Korea)

GROUP PHOTO AND LUNCH

1330-1400

MODELLING OF HUMAN COMPLEX DISEASESTakanori Amano (RIKEN, Japan)

1400-1430

ZIC3 LOSS-OF-FUNCTION IMPLICATES ELEVATED CANONICAL WNT SIGNALLING IN LEFT-RIGHTAXIS DEFECTS AND HUMAN HETEROTAXYRuth Arkell (Australian National University, Canberra)

1430-1500

PHENOTYPIC DISCREPANCY OF THE R229Q MUTATION OF RAG2 IN MICE (INTRODUCTION OF
CENTER FOR MOUSE MODELS OF HUMAN DISEASES [CMHD])
Han-Woong Lee (Yonsei University, South Korea)

1500-1530

USE OF MOUSE MODELS IN PERSONALISED MEDICINE
Simon Jiang (Australian National University, Canberra)

AFTERNOON TEA
1600-1630

NGS AND MURINE MODELS FACILITATE THE IDENTIFICATION OF GENES LINKED TO HEARING
LOSS IN HUMAN
Heon Yung Gee (Yonsei University, South Korea)

1630-1700

MOTOR PROTEIN MYOSINX IS A NOVEL REGULATORY FACTOR FOR LONGITUDINAL BONE
GROWTH AND TRABECULAR BONE MICROSTRUCTURES VIA THE NORMAL ENDOCHONDRALOSSIFICATION IN THE GROWTH PLATE
Taro Kataoka (Kumamoto University, Japan)

1700-1730

HEALTHY LONGEVITY OF MICE WITH A GENETICALLY MODIFIED HEMATOPOIETIC / BLOOD
SYSTEM
Yu-Chiau Shyu (Institute of Molecular Biology, Taiwan)

MEETING CLOSE

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PROGRAM - WORKSHOPF R I D AY F E B R U A R Y 2 2 N D
0900-0930

QUALITY CONTROL AND REPRODUCIBILITY
Atsushi Yoshiki (RIKEN BRC, Japan)

0930-1000

PRODUCTION & PRESERVATION – DEVELOPMENT OF MOUSE REPRODUCTIVE TECHNOLOGY
Toru Takeo (Kumamoto University, Japan)

1000-1030

CELL AND TISSUE MODEL SYSTEMSHelen Abud (Monash University, Melbourne)

MORNING TEA
1100-1130

ART OF PHENOTYPING
Ruth Arkell (Australian National University, Canberra)

1130-1200

IT ALL STARTS WITH A GOOD NECROPSY: SYSTEMATIC TISSUE COLLECTION, DATA CAPTURE,
ANNOTATION, AND INTERPRETATION
Colin McKerlie (Center for Phenogenomics, Canada)

1200-1230

BEHAVIORAL PHENOTYPING PIPELINE IN THE JAPAN MOUSE CLINIC
Tamio Furuse (RIKEN, Japan)

LUNCH AND GROUP PHOTO
1330-1400

GENOME EDITING OF MOUSE EMBRYOS
Shinya Ayabe (RIKEN Japan)

1400-1430

IMPROVING HDR EFFICIENCY FOR CRISPR/CAS9 EDITING IN MICE
Gaétan Burgio (Australian National University, Japan)

1430-1500

THE APPLICATION OF CRISPR/CAS9 TECHNOLOGY IN GENERATING COMPLEX MOUSE MODELS
Andrew Kueh (WEHI, Melbourne)

1500-1530

LINKING GENES AND PHENOTYPES FOR INDUSTRY THROUGH LARGE-SCALE ENU MUTAGENESISOF THE MAMMALIAN GENOME
Lucy Morris (Australian National University, Canberra)

AFTERNOON TEA
1600-1630

THE USE OF ANIMAL MODELS IN TRANSLATIONAL RESEARCH
Genie Chin (National Laboratory Animal Center, Taiwan)

1630-1700

DATA & BIOINFORMATICS: INCL. GENOTYPE-PHENOTYPE CORRELATIONS, ONTOLOGIES,
MATCHMAKER, MACHINE LEARNING, GA4GH(TBC)

DRINKS

FREQUENTLY
ASKED
QUESTIONSWhat is the weather
like in Melbourne?
With its variable climate, Melbourne
is warm to hot during Summer, withtemperatures averaging around 28C

Time Zone
During February, Melbourne is in Australian Eastern Daylight Time (AEDT), AEDT
is equal to Coordinated Universal Timeplus 11 hours (UTC +11).

during the day, and 16C at night, it is

Uber – Ridesharing site UBER offers

recommended that visitors bring clothes

uberX, and UberBLACK to and fromsuitable for warm days and cool nights.

Melbourne Culture
Shopping and shopping hours
Melbourne city shops generally openfrom 9:00am to 5:00pm but some havehours of 10:00am till 6:00pm, Monday
to Friday. On Friday, we call it late night
shopping day, which means that many
shops in the CBD and suburban shopping centres remain open until 9:00pm.
Here is some famous shopping destination around the CBD:
Bourke Street Mall – One of the mostpopular shopping hubs in the city, Bourke
Street Mall is buzzing with locals andtourists rushing from shop to shop buying from some of the country’s biggest
brandsThe Block Arcade – One of the most
iconic shopping destinations, The Block
Arcade is a heritage listed building located in the CBD.

In Melbourne you’ll discover a city
buzzing with dynamic and cutting-edgearts and culture. Below are must-go
places around CBD to know more about
Melbourne:
National Gallery of Victoria (NGV) – see
one of the most impressive collections ofEuropean, Asian, Oceanic and American
art at this iconic Melbourne gallery.
ACMI/Federation Square – venture into
Federation Square and explore the worldof film, television and digital media with
year-round exhibitions, rare screenings
and culture events.
Hosier Lane – well known by its “streetart”, walk down the famous bluestonelaneway and admire the street art thathas made the Melbourne urban art scene
known across the globe.
Degraves Street – come and have aquintessentially Melbourne cafe experience in Degraves street, one of the best
laneways in Melbourne

Melbourne Central – Known for thebusy train station, Melbourne Central is a
shopping and food mecca with a numberof popular stores under the one roof.
Emporium Melbourne – Focusing on
high-end shopping with a number ofinternational brands opening their doors.
DFO South Wharf (Direct Factory
Outlets) – For the best outlet shoppingin Melbourne, DFO South Wharf is theplace to go!

How do I get from theairport to the meetingvenue?

Where is the meetingvenue?
Walter and Eliza Hall Institute of Medical
Research (WEHI)
1G, Royal Parade, Parkville VIC 3052
(03) 9345 2555

Melbourne Airport. Simply download theUber app for iOS, Android or Windows
and request a ride. Uber is a cashlessservice and payment is made directly
through the app. It is a good idea todownload the app in advance.
At Melbourne Airport, request your ride
when you’re ready to walk outside, exit
the terminal and follow the signs to the
Ride Share pickup area.
Taxi – Melbourne’s taxis are a safe andconvenient way to get from the airport toyour destination. Taxi ranks are locatedon the ground floor outside Terminals 1
and 3. Taxi fares are calculated according
to the distance and duration of the journey and will vary based on the numberof people and time of travel. Additionalcharges apply if you travel on somepublic holidays, late at night, with fiveor more people or pay with credit/debitcard. Taxi Fare Estimator: www.taxifare.
com.auCar hire and other transport can befound at: www.melbourneairport.com.au.

How far away is themeeting venue to myaccommodation?
If you are staying at our suggested hotel– Mercure North Melbourne, it is about
8mins (650m) walking distant to theconference venue. Please see map for
direction:

When and where is
the meeting dinner?
20 February 2019, 7 – 10 PM
University House Professors’ Walk - The
Main Dining Room
112, Professors Walk, The University of
Melbourne VIC 3010
Please be aware that for walking todinner venue, Tin Alley is only accessible
via Swanston Street, as the Royal Parade
entrance is closed for works or you could
follow this map.

What food is included
in my registration?
Morning tea, lunch and afternoon tea is

Water
Melbourne tap water is filtered, fresh andsafe to drink.

provided each day.

Special dietary requirements
The venue or the caterer will be advisedof any special diet preferences you haveindicated on your registration form. A
special buffet table will be set aside in

Visitor Information

the foyer for dietary requirements.

For more information about local attrac-

information or you may ask the Leishman

tions, please visit:www.visitmelbourne.com

Please see the catering staff for more
Associates staff at the registration desk.

Registration desk
opening hours

Will there be internet
available?

Please direct any questions you may have

Delegates will have access to compli-

regarding registration, accommodation, or

mentary WiFi for the duration of thesocial functions to Leishman Associates

conference. Please note that movies,

staff at this desk.

music or illicit downloads are restricted.

The registration desk will be open at thefollowing time:
Wed. 20 FEB – 11:30 AM to 6:30 PM
Thurs. 21 FEB – 8:00 AM to 5:30 PM

It is not designed for accessing VPNs or
downloading large files.
Please connect to the ammra connection,
the password is ampc2019.
If you have trouble connecting please see
the staff at the registration desk.

I am a speaker, whatshould I do?
Please bring your presentation slides tothe registration desk at least 2 hours
before your session (or the catering break
before your session), the event coordinator will assist you to pre-load it to thelaptop. Please also be noted that speaker
will need to operate the slides from thelectern during your presentation.

I would like to pay
my registration fee
by cash on on arrival,
where should I go?
If you have selected to pay via Cashduring your online registration, pleasebring your invoice and exact dollar
amount to the registration desk, cash
payment must be made in Australia dollars. Change will not be available.

Is there security at themeeting?
The members of the organising committee and Leishman Associates accept
no liability for personal accident of loss
or damage suffered by any participant,accompanying person, invited observer or any other person by whatevermeans. Nor do we accept liability forany equipment or software brought tothe conference by delegates, speakers,
sponsors or any other party. Please

What is the dress
code for the meetingand social functions?
Dress code throughout the event is smart
casual or informal business.

Where is my accommodation?

protect your personal property. Do notleave laptops, cameras, and other valuable items unsecured. Be conscious ofindividuals who appear out of place anddo not wear a conference name badge.
Advise Leishman Associates staff if thisdoes not occur.

Posters must be no larger than A0(1189mm high x 841mm wide) portrait.
Authors must bring their poster withthem to the Conference and advise
Leishman Associates staff at the registration desk when they arrive. We encourage authors to provide their own Velcro‘hooks’ to display the posters if possible.
All authors are asked to be alongside
their poster during poster session. The
Poster Session is marketed as an opportunity for delegates to approach theauthor of the poster and ask questions or
discuss any element of the information
displayed.

Name badges
All delegates, speakers, sponsors andexhibitors will be provided with a nameMercure North Melbourne is located atbadge, which must be worn at all times

the corner of Flemington Road and Har-

within during the conference, as it is

ker St, Melbourne VIC 3051. Please referrequired for access to all the conference

to the map opposite for directions to thesessions and social functions.

conference venue.

I have a poster for theposter session, whatshould I do?

Please collect your name badge at theconference registration desk.

How do I book my accommodation?

How do I pay for myaccommodation?

You can book your accommodation

When you book your accommodation

I would like to change
or cancel my accommodation booking?

through the online registration form or

your credit card details will be transferredby emailing Leishman Associates. You willto the hotel you have selected – please

Please email Leishman Associates to can-be asked to provide your check-in andconfirm this on check in with your hotel.

check-out date as well as your credit cardYour credit card will not be charged until

details to secure the booking. Payment

you check out. If someone is paying on

for your accommodation will not be taken

behalf of you, make sure you have filleduntil you check in or out of the Hotel.

and submitted a credit card authorization

Delegates are encouraged to book inform to your hotel.

advance as availability closer to the Con-cel or change your accommodation prior
to the Conference. If you need to cancel
your accommodation booking within 30
days of your arrival date any cancellation
fees will be subject to the hotel cancellation policy. Therefore, no accommodation
refund can be guaranteed within 30
business days of the Conference. If you

ference date is not guaranteed.

alter your accommodation booking after
you have checked in, please deal directly

Where and when is
the workshop beingheld?
22 February 2019
Walter and Eliza Hall Institute of Medical
Research (WEHI)
ADDRESS: 1G, Royal Parade, Parkville
VIC 3052(03) 9345 2555

Is there any parking
available at the meeting venue?

with the hotel. If you arrive 24 hours later than your indicated arrival day, charges
will apply.

WEHI has limited paid parking is available
along Royal Parade and in paid parking
facilities beneath the Institute. A small
number of temporary visitor parking baysin the underground parking lot and on
the Institute forecourt can be booked byprior arrangement.
Call WEHI’s reception on 03 9345 2555

What is the dress
code for the meetingand social functions?
Dress code throughout the event is smart
casual or informal business.

to arrange a parking permit or visit www.
wehi.edu.au for more parking details.

DISCLAIMER
The meeting reserves the right to amend or alter any advertised details relating to dates, program and speakers if necessary, without
notice, as a result of circumstances beyond their control. All attempts have been made to keep any changes to an absolute minimum.