HEALTH - FOODK E E P Y O U R M E TA B O L I S M B A L A N C E D ,N AT U R A L LY.

BERBEVIS®

B E R B E R I N E

P H Y T O S O M E®

Please note this documentation is available for various countries all over the world and hence it may containstatements or product classification not applicable to your country. The claims made are in reference to ingredients
only, hence they do not refer to finished products and they may not comply with Regulation EC n. 1924/2006.
The marketer of any finished product containing any ingredient is responsible for assuring that thedestination of the product and the claims made for the finished product are lawful and comply withall applicable laws and regulations of the country or countries in which the product is to be sold.

WHAT MAKES BERBEVIS® UNIQUE?

BERBEVIS® is an innovative, food-grade
ingredient based on the formulation ofberberine from the roots of Berberis aristata.
It sports a new custom Phytosome®
formulation, optimizing by 10-fold* thebioabsorption.1

BERBEVIS®, is a next-generation Phytosome® with a newcustom formulation leveraging onto 3 additional pillars:

SPECIFICATIONSBERBEVIS® is standardized to contain:
28-34% of berberine by HPLC
RECOMMENDED USE AND DOSE
BERBEVIS® is a light brown powder andmay be utilized in a variety of supplement
formulations.
Recommended dose: 550 mg once ortwice a day
TRADEMARKSBERBEVIS® is a trademark of Indena
S.p.A. and its logo and usage guidelines
are available from Indena.
*on molar basis and with observed dose linearity**PolyCystic Ovary SyndromeReferences
1Petrangolini G., et al. Evidence-Based Complementary 26 and AlternativeMedicine, vol. 2021, Article ID 7563889, 10 pages, 2021.
2
Rondanelli, M. et al., Nutrients 13.10 (2021): 3665.
3Rondanelli, M. et al., European Review for Medical and Pharmacological
Sciences 27 (2023): 6718-6727.
4Cesarone, Maria R., et al., Minerva Gastroenterology (2023).

indena.com•using pea proteins within the Phytosome® matrix
helps optimize berberine bioabsorption, as
reported in scientific literature;•using Indena's grape seed extract as a powerful,natural antioxidant to protect the intestinal mucosa
against the known gastrointestinal adverse effects oftraditional berberine, thus optimizing its tolerability
even in long term use.

BERBEVIS® is proven effective in the management ofhealthy blood sugar levels:3•It noticeably optimizes the blood sugar profile,positively modulating blood glycaemia insubjects with impaired fasting glucose (IFG):-11% after only 30 days of supplementation;•It optimizes insulin resistance significantly
achieving a remarkable -36% at the end of thestudy (based on HOMA index value after 90 days).

In a recent human study,4 the beneficial action of
BERBEVIS® on metabolic health was validated in aborderline hyperlipidemic population to evaluate theoptimization of blood lipid profile.
Subjects supplemented with BERBEVIS® and following ahealthy diet and lifestyle showed a statistically significant,positive modulation of lipid parameters, including totalcholesterol, triglycerides and HDL, while maintaining ahealthy body composition.
And what’s more is that BERBEVIS® did that with a single,
convenient 550 mg supplementation once a day for 3
months.
Since PCOS is an endocrine-metabolic disorder, Indena
decided to test BERBEVIS® that emerged as a winning
multi-target approach to PCOS thanks to an effective
modulation over blood sugar levels and support tohormonal balance.2
Furthermore, BERBEVIS®:•

has a positive effect on body composition,inducing the redistribution of adipose tissue;•is helpful against acne, typical symptom of PCOS,
both reducing discomforts and thus improving
quality of life.

,™ trademarks of Indena S.p.A. © 2024, Indena S.p.A.

SCIENTIFIC EVIDENCE
BERBEVIS® is supported by a humanpharmacokinetics,1 and three humanstudies.2-4

Berberis aristata extract is more soluble than pureberberine in simulated gastrointestinal fluids;®

BERBEVIS® is scientifically proven toprovide positive support across multiple
parameters associated with metabolic
health in a plethora of multifactorial
disorders – including impaired fasting
glucose, borderline hyperlipidemia andPCOS.**•DPR0305 - 10/2021*05/2024

WHAT IS BERBEVIS®?