Work withrelevant cell
modelsCell Models
Ensure consistent
performance acrossevery projectFor those special projects
From target identification to pre-clinical studies, every
project is different. Benefit from Horizon resources andexperience to design your exact cell model.

Defined clonal Ready-to-go
cell models
models
Delivered in as little as 10 weeks
Each Express cell model includes up to 2 clones toavoid clonal bias. Parental cell line as a wildtype
control delivered along with a final project report.

From consultation to custom cell modelExpress edits available
Knockout
Delivery ~ 10 weeks• Consultation withspecialist team
• Detailed work plan

• Reagent design• Single cell cloning• Cell line on-boarding& characterization• QC: genotypevalidation• Gene targeting• Mycoplasma &sterility testing• Delivery of 2clones for yourmodel• Final report

Mono-allelic point mutation
Delivery ~ 12 weeks

Project duration

Choose your cell line

Non-standard
single-gene
KO indel• Project initiated when PO received

DoubleKO indelSingle genecodingknock-in• Pay on successful delivery

Choose your cell line or provide your own
at no extra cost
There are hundreds of pre-licensed cell lines
available, or incorporate your in-house cell line.
Including iPSCs and primary T cells.

Single gene tag / reporter
TurboGFP /TurboRFP

HiBiT,LgBiTChoose from over 10,000
well-established cell lines.
HAP1 cell lines
Choose from the single largest bank of isogenic
cell lines - trusted by research labs across the world.
Peer-reviewed publications in Nature, Journal of
Cell Science, Cell Reports and many more...

Recapitulate disease phenotype.

• Standard edits at a fixed price

Custom edits available

Order easily online – simply enter your gene ofinterest and choose the cell background andclone to best suit your research.

Cancer-related cell lines

Ensure project successSelect your edit

Each ready-to-go model is delivered with theparental cell line as a wildtype control.

One cell background, multiple applications.
There are hundreds of pre-licensed cell lines
available, or incorporate your in-house cell line
at no extra cost.

Monthly progress updates from the project management team

Knockout and knock-in models
delivered in as little as 10 days

Choose from knock-in and knockout cell models
in many standard cancer cell lines such as DLD1,MCF10A, and HCT116.

Partnered with The Human Protein Atlas
NanoLUC
HPA HAS SELECTED HORIZON’S CRISPR-EDITED KNOCKOUT CELL MODELS TO FURTHER EXPAND THE KNOWLEDGEAVAILABLE IN ITS CELL ATLAS PROGRAM, TO ADVANCE OUR UNDERSTANDING OF THE GENETIC DRIVERS OF DISEASE.

Request a consultation via
sales@horizondiscovery.com
or contact your Horizon representative

horizondiscovery.com

Get an instant online quote athorizondiscovery.com

Order online athorizondiscovery.com

horizondiscovery.com

Horizon in cellline engineeringWith more than a decade of experience in cell line engineering. Horizon
Discovery are trusted by global pharmaceutical and biotech clients tosupport a range of therapeutic research and development areas. Theengineering team has completed 1000s of edits in 100s of cell types,
facilitated by in-house automation for increased efficiency and capacity.
Horizon Discovery also provides innovative tools and services to help
identify genetic drivers behind disease, validate diagnostic workflows,
and deliver new therapies for precision medicine.

Contact us

Horizon Discovery, 8100 Cambridge Research Park, Waterbeach, Cambridge CB25 9TL, United Kingdom©2020 The Horizon logo and other trademarks are the property of Horizon Discovery Limited, unless otherwise stated. DHARMACON is a trademark of Dharmacon Inc.

V10420t +44 (0)1223 976 160 (UK) or +1 800 235 9880 (USA); +1 303 604 9499 (USA)f +44 (0)1223 655 581 e info@horizondiscovery.com w horizondiscovery.com/contact-us