Life science
Cardiovascular medicine

Prognostic significance of the HFA-PEFF score in patientswith heart failure with preserved ejection fraction
Department of Cardiovascular Medicine, Graduate School of Medicine
Specially Appointed Assistant Professor Yohei Sotomi

https://researchmap.jp/sotomiyohei?lang=en

Professor Yasushi Sakata						https://researchmap.jp/C4589?lang=en

Our study aimed to test the prognostic ability of the HFA-PEFF
score for the diagnosis of heart failure with preserved cardiac
function (HFpEF). In PURSUIT-HFpEF, a prospective, multicenter,observational study conducted at 26 Osaka University-affiliatedhospitals, data from 871 patients with acute decompensated heart
failure were collected and followed for an average of 399 days.
The HFA-PEFF score, calculated based on discharge data, wasevaluated to predict risk of all-cause mortality and heart failure rehospitalization. The results showed that the group of patients witha high HFA-PEFF score (6 points) had a significantly higher risk ofthe primary endpoint than the group with a low score (2-5 points).
This indicates that the HFA-PEFF score is a valid tool for predicting
the prognosis of patients with HFpEF.

▍ Background & Results
The Heart Failure Association (HFA) of the European Society ofCardiology has introduced a new comprehensive diagnostic algorithm of heart failure with preserved ejection fraction (HFpEF). The
central component is the HFA-PEFF score, a scoring system thatcombines echocardiographic parameters and natriuretic peptide
test results. The score is based on three domains: functional, morphological, and biomarker, which are closely related to left ventricular filling pressures The HFA-PEFF score indicates the severityof HFpEF and serves as a diagnostic tool. Although this scoring
system was developed as part of a diagnostic algorithm, it has
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km_death_hf_from_discharge▍ Significance of the research and Future perspective
This study highlights the value of the HFA-PEFF score not only asa diagnostic tool, but also as a prognostic tool. Each domain of thescore is noninvasive and can be easily assessed in routine clinicalpractice, which may be helpful in determining post-discharge treatment strategies. The results of this study need to be revalidated byfurther studies in other countries.
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been hypothesized that it may also be a useful tool for predicting
clinical outcomes. Our study aimed to evaluate the prognostic significance of the HFA-PEFF score on the clinical outcome of patientswith HFpEF through a large prospective multicenter registry.
The PURSUIT-HFpEF study was a prospective, multicenter, observational study conducted at 26 Osaka University-affiliated hospitals (N=871) to collect clinical, echocardiographic, and outcome
data from patients with acute decompensated heart failure with left
ventricular ejection fraction >50%. Kaplan-Meier analysis showeda significant difference in risk of the primary endpoint between
patients with a low HFA-PEFF score (score 2-5) and those with ahigh HFA-PEFF score (score 6). (adjusted hazard ratio 1.446, 95%
confidence interval [1.099-1.902], P = 0.008). This study suggeststhat the HFA-PEFF score is not only a diagnostic tool, but is also
clinically useful as a practical prognostic tool. This scoring system
could be used to more accurately predict the post-discharge riskof HFpEF patients and provide important information for developing an appropriate treatment plan.

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P a t e n t
Tr e a t i s e

Sotomi, Yohei; Iwakura, Katsuomi; Hikoso, Shungo et al. Prognostic significance of the HFA-PEFF score in patients with heart failure with preservedejection fraction. ESC Heart Fail. 2021;8(3):2154-2164. doi: 10.1002/ehf2.13302

URLK e y w o r d heart failure, HFpEF, HFA-PEFF score

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