ADVERTORIAL

Kawasaki City: The KING SKYFRONT Innovation
Hub for 21st Century Life Science
Adjacent to Tokyo International (Haneda) Airport lies a unique 40-hectare science and technology innovation hub, the Kawasaki INnovation
Gateway (KING) SKYFRONT. The mission of this futuristic facility is tofind actionable solutions to issues in regenerative medicine, cancer treatment, and the prevention of ‘lifestyle’ diseases such as obesity. Importantly, the Japanese government has designated the KING SKYFRONT to bea special zone for international competitiveness development, bestowing
it special privileges including reduced corporate taxes and governmentbacked financial support for projects launched there.
“KING SKYFRONT is the first important step in establishing the Tonomachi area of Kawasaki City as Asia’s Silicon Valley,” says Nobuhide
Kobayashi, executive director of the Coastal Area International Strategy
Office, Kawasaki City. “We are confident that the easy access provided byHaneda Airport, in conjunction with the excellent research and development infrastructure, will form the basis for unprecedented business opportunities growing out of innovative science, medicine, and technology.”
Kobayashi has reason to be confident. Kawasaki City, with its 1.4 million
inhabitants, is already home to many blue chip companies including Aji-nomoto, Toshiba, Fujitsu, and NEC as well as other global brands thathave played a central role in the growth of Japan’s economy over the lastcentury.
The KING SKYFRONT is at the heart of the Keihin Industrial Region, encompassing areas of Tokyo and Kanagawa Prefecture, and Haneda
Airport. This location offers unprecedented land, sea, and air access tocities within Japan, and the international airport connects the area toAsia, North America, and Europe. “Life science is one of the strategicareas for KING SKYFRONT,” says Kobayashi. “We envisage that visiting scientists, medical doctors, and business people will be able to arrive at Haneda in the morning, go directly from the airport to KINGSKYFRONT, participate in meetings, and return to their country on anevening flight.”
In addition to the excellent technological infrastructure and access,KING SKYFRONT is located within commuting distance of international
schools and medical clinics run by English-speaking clinicians—important factors to consider for creating long-term collaborations with overseas partners.

Launch of the innovation
Center Of Nanomedicine
The innovation Center Of Nanomedicine (iCON) is set to be the flagshipof the KING SKYFRONT development. With government startup
funding of approximately ¥3.5 billion (US$34.7 million), construction
on the project is due to start in 2013,
Kazunori Kataokawith a formal launch in 2014. Research at the center—carried out by groups from academia, industry, andgovernment—will address such diverse issues as the medico-economic
impact of aging populations, curbing the increasing cost of medical care,
improving point of care treatment, and establishing new medical markets
in developing countries.
Translation of research ideas to the marketplace and fabrication/manufacture are two of the main strategic pillars of the center, emphasizes Professor Kazunori Kataoka of the University of Tokyo, who will be directorof research in nanomedicine at the center. “The KING SKYFRONT willoffer an open-innovation approach to meet our targets,” says Kataoka.
“The proximity of Haneda Airport, the availability of clean rooms andrelated infrastructure for nanofabrication, industrial participation, andprofessionals to advise on the commercial aspects of research are essential
ingredients for taking creative ideas from the laboratory to the marketplace. KING SKYFRONT can be viewed as a highly condensed versionof Silicon Valley.”
Kataoka is no stranger to big ideas and translational research, having
launched the company NanoCarrier in 1996 to commercialize nanosized
micelles for targeted drug delivery for the treatment of cancer and otherintractable diseases. Notably, NanoCarrier is listed on the Mothers (marketof the high-growth and emerging stocks) section of the Tokyo Stock Exchange and valued at ¥100 billion (US$985 million).
Underscoring Kataoka’s internationally recognized contributions toinnovative research in nanobiotechnology, he recently received support
from Japan’s prestigious national Funding Program for World-Leading Innovative Research and Development on Science and Technology (FIRST)
program. With funding of ¥3.6 billion (US$35.7 million) over five years,
Kataoka’s team will address the following topics: (1) Treatment of cancer
stem cells using targeted drug delivery systems in which nanometer-sized
drug carriers are able to selectively bind to cancer cells; (2) Treatmentof neurological diseases such as Alzheimer’s disease using functionalized
micelles capable of passing through the blood-brain barrier; (3) Development of nanovaccines that can be stored for long periods of time at room
temperature; (4) Fusion of drug delivery platforms with medical devices
for minimally invasive “chemical surgery”—such as ultrasonic waves that
activate drugs at specific places in the body—to reduce the length of hospital stays for patients; and (5) Development of point-of-care diagnostic
devices, such as the use of portable nanofabricated systems to detect microRNAs and specific enzymes.
Kataoka emphasizes the importance of what he calls ‘smart healthcare.’“Reducing the time a patient stays in hospital would be a tremendous
contribution to society. I am confident that research at iCON can achievethis.” As an example of how nanomedicine may eventually be used bymillions of people, Kataoka describes the development of the advanced
technology necessary to produce hybrid cars. “These cars require a lot ofexpensive technology. But mass production has enabled cost reductions towithin the price range of millions of people worldwide. I predict a similar
scenario for nanomedicine.”Produced by the Science/AAAS Custom Publishing Office

ADVERTORIAL

Artist’s Impression of the innovation Center Of Nanomedicine (iCON)

Hiromichi Kimura

Tomohiro Anzai

Participants in the innovation Center
Of Nanomedicine include:
Academia and National Institutes Stanford University (USA)The University of Tokyo
Karolinska Institutet
Tokyo Institute of Technology(Sweden)
Tokyo Women’s Medical University
Industry
National Cancer Center (Tokyo)
Central Institute for Experimental Animals Fujifilm Corporation
Nikon Corporation
Keio University (Tokyo)
NanoCarrier Co., Ltd.

“We will not only have people from different academic
backgrounds but there will also be people from industry as
well as government administrators.” —Hiromichi Kimura

From Lab to MarketTechnology transfer at iCON will be managed by two professors
from the University of Tokyo: Hiromichi Kimura, in charge of Pharmaco-Business Innovation at the Graduate School of Pharmaceutical Sciences, and Tomohiro Anzai, a member of the Translational
Research Initiative.
Kimura’s academic background is in biochemistry. After graduating from the University of Tokyo, he joined a major life sciences-based
company in Japan before moving to the U.S. to complete an Master ofBusiness Administration and Ph.D. at Stanford University. “I now have myown consultancy company as well as the post at the University of Tokyo,”says Kimura. Anzai is also a graduate of the University of Tokyo where
he trained as a molecular biologist. He spent some time at a consultancy
company, because he “was interested in the commercialization of researchideas,” before joining KING SKYFRONT. Anzai also works with the University of Tokyo Hospital on technology transfer.
Kimura and Anzai stress that the interdisciplinary nature of the projects
at KING SKYFRONT and iCON will require good communication skills
between project members. “We will not only have people from different academic backgrounds but there will also be people from industry as
well as government administrators,” says Kimura. “Our biggest challenge
will be to formulate ways to ensure that physicists, medical doctors, andchemists can communicate with investment bankers, lawyers, and patent
attorneys. They may speak different languages, but they have the same
goal of making iCON a success.”

Laying the Foundations for a Global Innovation HubThe Central Institute for Experimental Animals (CIEA)—internationallyrecognized for research on the use of induced pluripotent stem cells forthe treatment of spinal cord injuries and Alzheimer’s disease—was thefirst major research institute to move to KING SKYFRONT, transferring
its facilities in July 2011.
March 2013 saw the opening of the Life Science and Environment Research Center (LiSE) to promote collaborative research in the life sciences, and consisting of a multipurpose facility housing laboratories fromboth Kawasaki City and the private sector.
In 2016, the Japanese National Institute of Health Sciences (NIHS) will
move from Tokyo to the KING SKYFRONT. The NIHS plays a central
role in regulatory science in Japan and at KING SKYFRONT it will establish global standards for new drugs and medical technology developedby researchers there.
KING SKYFRONT has attracted attention from overseas companies
including Johnson and Johnson, which will establish an R&D and training
center onsite.
“The world’s life sciences community willcontinue to ‘organically’ lay the foundations fora global innovation hub for research,” says Kobayashi. “It’s an exciting time at Kawasaki Cityas KING SKYFRONT evolves into a global basefor research in the 21st century.”Location of KING SKYFRONTConvenient access to Haneda Airport(Tokyo International Airport)
Access to KING SKYFRONT
By car: 10 minutes from Haneda Airport
By train: 10 minutes from Kawasaki Station, 30
minutes from Tokyo Station, 75 minutes fromNarita Airport
Thanks to its convenient location, you can enjoy
a wide range of comfortable amenities closeby, including residences, education, shopping,cultural attractions, and medical care.

Attractions in Kawasaki City
Many exciting music, art, sports, nature,and shopping attractions are available
throughout the city.
Music & Art
MUZA Kawasaki Symphony Hall
Montreux Jazz Festival in Kawasaki
Taro Okamoto Museum of Art
Japan Open-Air Folk House MuseumSports
TAMA River Run Festa
Kawasaki Frontale (The city soccer club)
NatureTama River
Ikuta Ryokuchi ParkShopping
Lazona Kawasaki PlazaLA CHITTADELLA

Support for Companies
and Institutes
Due to its designation by the government as aSpecial Zone for International Competitiveness
Development, special benefits are available,
including:• Favorable tax treatment• Financial support• Exemptions from certain local regulations.
Additionally, generous assistance is available forstartups and small- and medium-sized businesses in
the form of incubation facilities and business matchingservices.