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Category:Theories of aesthetics Category:Decision theory pl:FunkcjonalnośćThe mitochondrial citrate transporter: importancefor glycolysis and cancer. Mitochondria are hubs for the metabolism of cells and produce ATP by oxidative phosphorylation.
Glycolysis coupled to oxidative phosphorylation is the main source of ATP for cells, while fatty acid oxidation is necessary forsome kinds of cell growth. In the presence of oxygen, mitochondria mainly convert glucose to pyruvate and acetyl coenzyme A(acetyl-CoA), which are then transported to the cytosol for further metabolism. Mitochondria also contain an endogenous citratetransporter, which transports cytosolic citrate into mitochondria. This process allows the mitochondria to generate citrate forfatty acid synthesis, both by de novo synthesis and by reconversion from acetyl-CoA. Analyses of the yeast citrate transporter,
SCS2, indicated that mutations in SCS2 result in defects in mitochondrial physiology and proliferation, suggesting a crucial rolefor SCS2 in cell growth. Furthermore, the protein product of the human SCS2 homologue, CT1, is markedly elevated in certain
human cancers, including breast, colorectal, prostate, gastric and esophageal cancers, and is associated with a poor prognosis.
Furthermore, CT1 expression is suppressed by p53 and inhibited by TGF-β in a human cancer cell line. These findings suggestthat CT1 is important in the regulation of cell proliferation, suggesting that it may be involved in the development of several
human cancers. Therefore, an understanding of the function of CT1 may provide insight into the processes underlying theetiology of human cancer and provide opportunities for cancer therapy.As the demand for mass market digital media content,such as digital images and audio files, continues to increase, finding ways to store large amounts of data and managing thetransfer of data across networks becomes a significant issue for content providers. Traditional mass market digital content
delivery systems utilize terabyte memory disk arrays, and these systems have several drawbacks. First, a terabyte memory diskarray is large and expensive. Second, these memory disk arrays require large amounts of storage space and are thus, subject tospace limitations. Third, the transfer of data to and from a memory disk array is relatively slow. Fourth, the accessing andupdating of data requires a large amount of time, and the time delays involved with accessing and updating data

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