NATIONAL INSTITUTE FOR BASIC BIOLOGY& fl ~ II ~ iJf ~PJT

1987/88

lil.lii1L~16Jif~8tl

BRIEF SUMMARYThe National lr1stitute fm Basic Biology, NIBB, is a part the Okazaki National
Research Institutes located on a hill overlooking the old town of Okazaki. The
research institute is composed of three independent organizations, National
Institute for Basic Biology, National Institute for Physiological Sciences, andInstitute for Molecular Science.
NIBB is an interuniversity research institute with its own research programs
as well as cooperative programs to pmmote basic biology in Japan. The programsare 1) joint research programs in which university scientists are invited topa rticipate in research projects with NIBB members, 2) facility-sharing programs in
w hich university scientists utilize the institute's research resources, 3) graduate
student training programs in whieh graduate students from universities spend
fixed periods of time with the NIBB, and 4) international programs in which
foreign scientists are invited to NIBB to conduct research projects.

PROFESSOR T. S. OKADA

2INTRODUCTION
The National Institute for Basic Biology (N IBB) aims to faci litate
basic research in the biological sciences in Japan by conducting
advanced stud ies to elucidate various fundamental mechanisms
underlying living organisms. Research areas include studies of ce ll
growth. developm ent and differentiation. and control of various ce llfunctions. among others. The ultimate goal is to understancj themechanism of phenomena in eukaryotic organisms at the molecularlevel. Ana lytical approaches include biophysical. cell biological. andmolecu lar techniques. incorporating the latest methods of genemanipulation.
The NIBB. is an inter-university research institute. and as suchhas a two-fold mission: (1) to conduct in-house research and (2) tomake the facility available for collaboration with scientists outside
the NIBB. Thus. the NIBB is an "open" institute. The Institutecontains th ree departments. Ce ll Biology, Developmental Biology,
and Regulation Biology, which are divided into 13 divisions . Eachdivision is staffed by a full professor. an associate professor andtwo research associates. Six of the professional appointments areadjunct professorships; these individuals have joint appointments atother institutes in Japan. The NIBB sponsors joint research
programs with participating individuals or research groups nationallyand internationally.
The NIBB provides an opportunity to share reseach resourcesamong biologists in Japan and from abroad. It also sponsors
symposia on current topics at the Interd isciplinary level by inviting
participation by leading scientists in various related fields. both frominside Japan and abroad. Thus. the NIBB is becoming and willcontinu e to be an internationally recogn ized institute for conducting
ba sic resea rch in the biological sciences.

T.S. Okada. D.Sci.
Director General3--- - - - - - - - -ORGANIZATION OF THE INSTITUTEThe Okazaki National Research Institutes. ONRI, are composed of three individual Institutes. NIBB. Institute for Molecular Science (IMS). ana
National Institute for Physiological Sciences (NIPS). The president of ONRI is Prof. Saburo Nagakura. IMS and NIPS are headed by Professors Hiroo
lnokuchi and Setsuro Ebashi. respectively.

Policy and Decision Making
The Director General overseas the operation of the instituteassisted by two advisory bodies. the Advisory Council and Steering
Council. The Advisory Council is made up of distinguished scholars
representing various fields of science and culture. and advises the
Director General on the basic policy of the institute. The Steering
Council is made up of professors of the institute and an equal
number of professors from other leading universities in Japan. andadvises the Director General on the scientific activities of theinstitute. The Council advises on faculty appointments and on theinstitute's annual budget.

Administration
Administration of the institute is undertaken by the Administration
Bureau of the Okazaki National Research Institutes under the direct
auspices of the Ministry of Education. Science and Culture.
Currently the chief administrator is Mr. Kiyoshi Inoue.

Research
The institute conducts its research programs through three departments organized into 13 divisions. Each division has its own
research project and is staffed by a professor. an associate
professor and two research associates. A division forms a project
team and is expected to be reorganized when a division's project iscompleted. Half of the divisions are for adjunct professorship andare under professors who hold joint appointment with otheruniversities. The adjunct division has resident research associates.
The arrangement aims to facilitate exchange of research activities inJapan .
Technical Department manages the activities of research techniquesand help to promote research activities of each division and also tomaintain the research resources of the institute. The department
undertakes the technical education of its staff.

Research Support Facility
The research support facilities of NIBB consist of the Large-scale
Spectrograph Laboratory, Tissue and Cell Culture Laboratory, Laboratory Computer Facility, Plant Culture Facility, Plant Cell Culture
Facility, and Experimental Farm. In addition. seven facilities areoperated jointly with the National Institute of Physiological Sciences;
they consist of the Radioisotope Facility, Electron Microscope
Center. Center for Analytical Instruments. Machine Shop. Laboratory
Glassware Facility, Animal Care Facility, and Low-Temperature
FacilityCampusThe Okazaki National Research Institute covers an area of 150,000
m 2 with four principal buildings. The NIBB's main research building
has a floor space of 10,930 m 2 Two-thirds of the space wascompleted in 1982 and the remaining third in June. 1983. The
buildings to house research s!Jpport facility was also comple~ed inJune 1983.

4--------------

DEPARTMENT
OF CELL BIOLOGY
Chairman: Yoshihiko Fujita
Two research divisions and three adjunct research divisions are
conducting research on the structure and function of cells at themolecular level.

Division of Cell Mechanisms
Professor: to be appointed.
Associate Professor: Toshiyuki Nagata
Research Associate: Shigeyuki Kawano
Kazuo Ogawa
A new professor will be appointed to this division, which washeaded by .Professors Noboru Kamiya and Tsuneyoshi Kuroiwa.

Division of Bioenergetics
Professor: Yoshihiko Fujita
Associate Professor: Shigeru ltoh
Research Associate: Mamoru Mimuro
Kaori Ohki
Mechanisms involved in energy conversion in photosynthesis havebeen investigated. Special attention has been paid to the mechanism of homeostasis in the photosynthetic energy conversion
system. The study has I;Jeen conducted with algal systems andfocused on the regulatory change of the composition of the energy
conversion system in response to the light. The mechanisms of
excitation energy transfer in the light-haNesting antenna and of thephotochemical reaction in the reaction centers have also been
investigated with isolated functional protein complexes.

Division of Cell Fusion (Adjunct)
Professor: Tsuyoshi Uchida
Associate Professor: Masaru Yamaizumi
Research Associate: Masahiro lshiura
Kenji Kohno
Molecular and cellular biology of mammalian cells including humancells, aided by cell engineering and recombinant DNA technology,
are the research projects of this division. In relation to the action
mechanism for diphtheria toxin in mammalian cells, currently, thestructure and function of the elongation factor-2 (EF-2) involved in
the protein synthesizing system of mammalian cells have been
extens ively studied at the molecular level using cloned EF-2 genes.
Cosmid cloning has been established by constructing simplified
cosmid vectors and selecting adequate E. coli. Elucidation of themechanism for DNA repair in mammalian cells is also in progress.

Division of Cellular Communication(Adjunct)
Professor: Yoshiro Shimura
Associate Professor: Kenzo Nakamura
Research Associate: Kiyotaka Okada
The division pursues molecular biological as well as genetic
analyses on gene regulation mechanisms of higher plants, especiallyArabidopsis thaliana, a small crucifer. Our interests are on thegenes whose expressions depend on developmental stages or on
specific tissues, and genes which respond to environmental stimuli
such as light and temperature. We are also interested in the genes
responsible to cell divisiol'l and RNA processing proceduves.

5

Division of Cell Proliferation (Adjunct)
Professor: Yasuhiro Anraku
Associate Professor: to be appointed.
Research Associate: to be appointed.

The division conducts research into the mechanisms of cellproliferation and cell division cycle through genetic, biochemica l. andmorpho logical ap proaches. M ain projects are to explore the genetic
systems and molecular mechanisms of calcium control of organelle
biogenesis. mitosis. and cytoske leto n network.

DEPARTMENT
OF DEVELOPMENTAL
BIOLOGY

animals. particularly the hormonal control of oocyte growth, oocyte
maturation and ovulation. These studi es com bine biochemical.
ultrastructural and physiological approaches. Resea rch centersaround oocyte maturation in teleosts and sta rfish. In these animals.
our previous studies have established that three major mediators
are involved in the regulation of oocyte maturation: gonadotropin(GTH) or gonad-stimulating substance (GSS). maturation-inducing
substance (MIS) and maturation-promoting factor (MPF) . Th ese.
three mediators function sequentia lly at the levels of the follicle
layer, the oocyte surface and the oocyte cytoplasm, respectively.
Currently our research is concerned with (1) the characterization
and/or synthesis of teleost GTH and sta rfi sh GSS, (2) t he molecularmechani sms of biosynth esis of sa lmonid MIS, 17a, 20/:i-dihydroxy-4pregnen-3-one. and sta rfi sh MI S. 1-methyladenine, in ova ri an fol licle
ce lls. (3) the cha ra cterization of GTH receptors located on sa lmonid
ovarian fo ll icle cel ls, (4) the cha racteriza tion of the MIS receptors
located on the oocyte surface. and (5) the characte rization andfunction of MPF.

Division of Cell Differentiation
Chairman: Goro Eguchi

The department is composed of three research divisions and one
adju nct research division. and conducts research into the ce llularand molecular mechanisms of various processes that are 1nvolved indevelopmental phenomena.

Division of Reproductive Biology
Professor: Yoshitaka Nagahama
Associate Professor: to be appointed.
Research Associate: Hiroko Shirai
Takeo Kishimoto

The division condu cts research on the cellular and mol ecularmechan isms of formation and release of gametes in multicellular

6

Professor: Yoshiaki Suzuki
Associate Professor: to be appointed.
Research Associate: Shigeharu Takiya
Toshiharu Suzuki

M embers of the division have been analyzing developmental
regulation of the tissue-specific genes and the homeotic genes inBombyx mori. The silk fibroin ·gene start s to be transcribed
specifica lly in the posterior silk gland cel ls as soon as the si lk glandmorphogenesis has been accomplished in a late em bryonic stage,and is repeatedly switched on and off in the fol lowing stages. To
ana lyze th e molecular m echanisms of this ti ss ue- and stage-specifi c
regulation of transcription. we have developed ce ll-free transcription
systems from seve ral tissues and cultured cell s. Using thesesystems we have detected tissue-s pecific factor(s) that transacts onthe distal region of the upstream sequence of fibroin gene.
Currently we are concerned with how synthesis and specificity of
the factor(s) are regulated. In Bombyx mon, more than 20 homeotic
mutants that mapped to the proximal end of the 6th linkage group
had been described as the "E-group" during the period of 1930 and1960 in Japan. They exhibit a variety of developmental abnormalities
in organogenesis in various body segments, and in most cases
homozygosity of the mutant gene results in embryonic lethality.
These genes are probably regulating. some structural genes thatplay important roles in pattern formation. We have cloned some ofthese homeotic genes in order to analyze the molecular events
during embryonic development and hopefully to clarify the relationship between these regulatory genes and those structural genes
such as fibroin gene that is expressed tissue-specifically.

Division of Morphogenesis
Professor: Goro Eguchi
Associate Professor: Kenji Watanabe
Research Associate: Ryuji Kodama
Kiyokazu Agata

Mechanisms of differentiation and morphogenesis in multicellularorganization have been investigated at cellular and molecular levels.
The research has been currently focused on the following threeprojects. (1) The cell culture experimental system of chick embryo
pigment epithelial cel ls (PECs) has been established. This system
can produce a multipotential dedifferentiated state of PECs which
are able to redifferentiate to lens cells or pigment cells. By thissystem erwironmenta l factors controlling the transdifferentiation
have been analyzed, particularly focussing on the structural andfunctional changes of the cell surface relating to dedifferentiation
and redifferentiation of the PEC. The molecular mechanism ofspecific gene expression has also been analyzed in the same
system. (2) The mechanisms of pattern formation and stabilization of8

two dimensional epithelial tissue structures have been investigatedin vivo as well as in vitro experimental systems by computer
graphics. electron microscopy, micromanipulation and biochemical
techniques. Such approaches have also been extended to analyze
morphogenesis of three-dimensional tissue structures.
In addition to these two projects. (3) cell changes during morphogenesis of three-dimensional tissue structures have been analyzed in eye lens systems in vivo and in vitro, particularly focussing
on the cell surface functions.

Division of Developmental Biology(Adjunct)
Professor: lkuo Takeuchi
Associate Professor: Masaki lwabuchi
Research Associate: Masao Tasaka

Regulation of development has been investigated at cellular andmolecular levels with the developmental system of the cellularslime molds. Currently, the research is being carried out along thefollowing three lines. (1) Cloning and analysis of genes specifically
expressed in pathways of spore and stalk cell differentiation andelucidation of the regulatory mechanisms of their expression. (2)Analysis of non-histone chromatin proteins with the hope of theirinvolvement in regulation of cell-type specific gene expression. (3)Analysis of cell movement during formation of differentiation pattern
within the tissue and elucidation of the mechanism of cell sorting.

DEPARTMENT
OF REGULAliiON BIOLOGY
Chairman: Ken-ichi Naka
The department has two divisions and two adjunct divisions. andconducts research on the information processing and control
mechanisms in biological systems.

Division of Sensory Processing
Professor : Ken-ichi Naka
Associate Professor: Shozo Yasui
Research Associate: Hiroko Sakai
Eiki Hida
This division's research activity is focused on ihformation processingin the vertebrate visua l system and is a cont inuation of researchoriginating at the California Institute of Technology in 1968 and thenconducted at the University of Texas at Galveston in 1977. This
research is characterized by unique choice of preparation as well asof methodology Owr principal preparation is the retina of channel
catfish. !ctalurus punctatus. The reti1:1a is very simply organized an dour effort has made it one of the most extensively ana lyzed
components in the centra l nervous system. We have also pioneered
the application of the Wiener's theo ry on nonlinear ana lysis or
wh ite-noise analysis. Our application is the most extensive exampleof the use of Wiener's theory.
Our analysis has shown that information processing in the retina iscomposed of three stages: 1) Piecewise linea rization in the outerre tina. 2) generation of static nonlinearities in the amac rin e ce ll s.
and 3) encoding of processed information into spike trains.
In the more classic field of morphology, we have discovered three
new synapses. a) ~he synapse made by the horizontal ce ll s back to

10------------

the receptors, b) the synpase made by the horizontal cells onto theamacrine cells, and c) the synapse made by the ganglion-cell
dendrites.

Division of Cellular Regulation
Professor: Norio Murata
Associate Professor: Hideaki Nakashima
Research Associate: Takao Kondo
Mitsue Miyao
lkuo Nishida
This division studies two important phenomena in higher plants andmicroalgae: (1) The molecular mechanisms of low-temperaturesensihvity and adaptation to temperatu re stress . (2) The structureand function of chloroplast membrane proteins in photosynthesis.
The temperature work emphasizes the participation of biologicalmembranes and membrane lipids. The enzymes Which produce
specia l lipid molecules that are responsible for the low-temperaturesensitivity and their genes are under investigation . The photosynthesis research focusses on the machinery of the oxygen-evolving
complex. The ultimate goal of this res.earch is to elucidate thethree-dim ensiona l structure of the oxygen-evolving complex.

Division of Biological Regulation (Adjunct)
Professor: Hidemasa lmaseki
Associate Professor: to be appointed.
Research Associate: Kotara Yamamoto
Satoru Tokutomi
Th e research in this division aims to study responses of plants toenvironmental stimu li at the biochemical and molecular levels.
Special attention is paid to the dev.elopmenta l changes of cellfunctions during co nversion of imnnature leaves to matme leaves ofleguminous plants as affected by light. plant hormones and ageing.
and to mechanisms of acquisition of thermotolerance by a temporal
treatment a~ a high temperature.

TECHNICAL DEPARTMENT
Head: Hachiro Honda

Division of Behavior and Neurobiology(Adjunct)
Professor: Katsuhiko Mikoshiba
Associate Professor: Masaharu Ogawa
Research Associate: Takaaki Tamura
In our research division. we are studying the mechanism ofdevelopment. growth. and differentiation of the mammalian nervous
system at the molecular level. The main themes of our division are:(1) Studies on myelin-deficient mutant animals.
We have produced several mutants with abnormalities at different steps ofmyelinogenesis . We are studying myelination as a typical morphogenetic phenomenon in the central nervous system. and also as
a neuron-glia inter-relationship.
(2) Studies on the mechanism of brain specific gene expression .
We are studying these subjects with both in vitro and invivo systems . In the in vitro system. we are studying promoter
activity of myelin basic protein (MBP) and proteolipid protein (PLP)
genes by cell-free transcription assays. In the in vitro system. weare utilizing the cells from a neurological mutant mouse termed
shiverer. The shiverer mouse is characterized by the absence of
MBP. Most of the MBP gene is deleted . We are studying themechanism of MBP gene expression by introducing the MBP gene
into various types of the cells in shiverer.
(3) Studies on the function of brain-specific proteins.
Brainspecific proteins. such as MBP. PLP. and neurofilament (NF) wereartificially expressed in various stra ins of cell lines including NIH3T3
cells by retrovirus vector mediated gene transfer. Localization andeffect of protein production on morphology have been investigated.

The Technical Department is a supporting organization for researchers and reseach organizations within the NIBB. The department
develops and promotes the institute's research activities and. at thesame time. maintains the researcn functions of the institute.
The department is organized into two groups: one. the Common
Facility group. which supports and maintains the institute's common
research facilities and the other. the Research Support group, whichassists the research activities .
Technicians participate. through the department. in promoting theircapability through mutual enlightenment and education so that theircapability in technical areas develops.
Staff:
Common Facility Group
Chief:
Hiroyuki Hattori
Tissue and Cell Culture Laboratory:
Masahiro Kawaguchi
Large-Scale Spectrograph Laboratory:
Mamoru Kubota
Experimental Farm: Chieko Nanba
Laboratory Computer Facility:
Masahiro Nasu
Radioisotope Facility:
Kazuhiko Furukawa
Yukie Miyamoto
Kanako Funadera
Center for Analytical Instruments:
Hiroko Kajiura
Hisashi Kojima

11--------

Fumie Seto
Laboratory Glassware Facility:
Toshiki Ohkawa
Hisaya Uemura
Research Support Group
Department of Cell Biology:
Soichi Nakamura
Akio Murakami
Masayo lwaki
Department of Developmental Biology:
Shinji Adachi
Mayumi Nasu
Kaoru Kato
Miyuki Katoh
Noriko Sakurai
Department of Regulation Biology:
Yoll,ko FujimuraYu-ichiro Ando
Soh Hidaka
Shoichi Higashi

RESEARCH RESOURCE
There are four categories of research support facilities available toresearch members and visiting biological scientists: 1) Campus-wide
facilities (CENTRAL COMPUTING CENTER and LIBRARY). 2) NIBB's
own research support facilities (RESEARCH SUPPORT FACILITY.
intramural). 3) facilities jointly maintained by the NIPS and the NIBB
but managed either by the NIPS (ANIMAL-CARE FACILITY) or by
the NIBB (RADIOISOliOPE FACILITY). 4') facilities jointly run by
NIPS and NIBB (CENTER for ANALYTICAL INSTRUMENTS. ELEC-

12

l'RON MICROSCOPE CENTER. LABORATOR~ GLASSWARE FACILITY. MACHINE SHOP and LOW-TEMPERATURE FACILITY)RESEARCH SUPPOR]FACILITYHead of Facility: Yoshiaki Suzuki
Faculty: Masakatsu Watanabe (Spectrograph)
Yoshio Hamada (Tissue and Cell Culture)
The facility maintains large-scale experimental equipments andfacilities for growing and maintaining biological specimens. The
facility is shared among the research members. and has fivelaboratories.
The large-scale spectrograph laboratory: This laboratory hCJS thelargest spectrograph in the world custom-built by Naka works.
HITACHI Ltd. The spectrograph runs on a 30KW-Xenon arc lamp
and has a compound grating-surface composed of 36 sma ller
individual gratings. A computer controls the positioning and timescheduled light exposures of 12 speciment boxes.
Tissue and cell culture laboratory: This is a facility for tissue andcell culture. This laboratory is equipped with safety rooms which
satisfy the P3 physical containment level. This facility is routinely
used tor DNA recombination experiments.
Laboratory computer facility: The NIBB's computing is handled by aDigital Equipment Corporation's VAX 11/780 computer with a
Floating Point System AP120B array processor and a Spatial Data's
image digitizer. An extensive software system tor time-series
analysis is available as well as a limited number of image
processing routines.

Plant Culture facility: There are large number of culture boxes.
cubicles, and a limited number of rooms with environmental control
for plant culture.
Experimental farm : This facility consists of two 20 m 2 glasshouses with precision temperature and humidity control. a limited
farm. a large (88 m 2 ) and a small (45 m 2 ) green house with
automatic sprinklers and wir~dow control. two (30- and 50-tc>n) operl
aquariums and several smaller tanks. The facility also includes abu ilding with office. storage and work-space .
Plant Cell Culture Facility : Autotrophic and heterotrophic culture
devices are eqwipped for experimental cultures of plant andmicrobial cells.

RESEARCH FACILITIESRADIOISOTOPE FACILITIES(managed by NIBB)Head of Facility: Voshihiko Fujita
Faculty: Kohji Hasunuma

The facility is composed of a cent0r and two subcenters. one in
NIBB and the other in NIPS. The facility is being used for molecularanalyses of eukaryotes. At the center a variety of radioisotopes
such as 3 H. 14 C, 22 Na. 32 P. 35 S. 45 Ca and 125 1 are mainly handled aswell as various species of beta and gamma-ray emitting nucleides.
A P3-level laboratory for recombinant DNA research is included in
the center facilities. At the substations. only a limited variety ofradioisotopes such as 3 H, 14 C and 32 P are processed. The
substation in NIBB is equipped with a P2-level recombinant DNA
research laboratCJ ry. The members of the Radioisotope Facility
maintain and control the centers. and give users appropria~eguidance for radioisotope handling . The facility members conduct
also their own research on the analysis of mutaflts in themetabolism of cyclic nucleotides in Neurospora crassa. The mutants

14

exhibit several charac~ eristic features such as rhythmic conidiation.
sensitivity to light. lack in the production of protoperithecium andabnormality in meiosis. The goal of the research is to isolate andcharacterize the genes for the regulation of cyclic nucleotides with
DNA recGmbination techniques .

ANIMAL-CARE FACILITIES(managed by NIPS)
Vivarium : This is a 2,000 m 2 building for maintaining land animals.
including insects. Operations and experiments of a limited scope
may be performed im the vivarium.
Aquarium : This is a 600 m 2 facility for both fresh- and sea-water
animals. There are 10 ten-ton and 31 0.5-ton tanks in addition to
one seven-ton and one two-ton circular tanks. All tanks areindividually temperature controlled and are supplied either with
deionized water or seawater. There is a lorry with a one-tontemperature-controlled tank to transport aquatic animals and plants.

RESEARCH FACILITIES RUNJOINTLY WITH THE NIPSELECTRONMICROSCOPE CENTER
This facility maintains the following microscopes for the use by theinstitute's members as well as researchers from other universities
and research institutions.
Transmission microscope : Hitachi H-500 125KV. JOEL 100-CX and
200-CX 100 and 200KV and Philips EM-400HM 120KV.
Transmission scope, analytical: JOEL 20()-CX. 200KV.
Scanning scope: Hitachi S-450 25KV.

CENTER FOR ANALYTICALINSTRUMENTS
Head of Facility: Norio Murata
The Center for Analytical Instruments consists of the following fivesections. (1) Chemical analysis. (2) Preparation of Biological Materials. (3) Spectroscopic analysis. (4) Physical analysis. and (5)Microscopic analysis. Each section is equipped with instruments forgeneral use as listed below.
1. Sections for Chemical Analysis
Amino Acid Analyzer
HPLC
Peptide Sequence Analyzer
Peptide Synthesizer

HITACHI 835
JASCO TRrROTAR Ill
JOEL JAS-47K
BECKMAN 990C

2. Section for Preparation of Biological Materials
Coulter Counter
COULTER ZB
lsotachophoresis System
LKB 2127 TACHOPHOR
Preparative Ultracentrifuge
BECKMAN L8-80
Two Parameter Cell Sorter
BECTON-DICKINSON
FACS-11Spectropolarimeter
4. Section for Physical Analysis
Analytical Ultracentrifuge
Differential Scanning
Calorimeter
EPR Spectrometer
GC Mass Spectrometer
Superconductive FT-MNR
Spectrometer
Viscometer

JASCO J-40S

HITACHI 282
PERKIN-ELMER DSC-2
BRUKER ER 200D
HITACHI M-80
BRUKER WM 360 wb
CONTRAVES RM-30

5. Section for Microscopic Analysis
2-Dimension
JOYCE LOEBL 3CS
Microdensitometer
NAC MOVIAS GP-2000
Film Data Analysis System
KONTRON MOP-AM03
Image Analyzer
KONTRON IBAS-1.11
Interactive Image Analyzer
CARL ZEISS MPM 03-FL
Microscope Photometer

3. Section for Spectroscopic Analysis
Atomic Absorptiol'l
Spectrophotometer
PERKIN-ELMER 603
Differential Refractometer
CHROMATIX KMX-16
Dual-wavelength.
Spectrophotometer
HITACHI 557
Infrared Spectrophotometer
JASCO A-302
Laser-Raman
Spectrophotometer
JASCO R-800
Light Scattering Photometer
CHROMATIX KMX-6DC
Spectrofluorometer
HITACHI MPF-4
Spectrophotometer
GILFORD 250
HITACHI 330

15

COOPERATIVE RESEARCH ACTIVITIESThe NIBB sponsors four cooperative research activities.
Individual and group cooperative research program: Scientists from other Japanese universities andresearch institutes are invited to undertake joint research projects with the in stitute's members.
Limited funds are available for travel and expenditures related to the projects.
Research conferences: The NIBB sponsors resea rch conference on important subjects in biology.
Ten to twenty scientists are invited and intense discussion is held for two to three days. The NIBB
provides financia l support for the participants. Conferences may be initiated by the institute's
members or scientists from other institutes.
Faci lity-sharing program: Scientists from other universities are permitted to use specified
instruments maintained by the NIBB. No financia l support is available except for the Large Sca leSpectrograph whose user is provided with limited financial support.
Graduate student program: Graduate students from other universities may spend a fixed period oftime with members of NIBB. This allows students to have experience with the very modern facilityof NIBB. The NIBB is expected to have its own graduate program in the near future.

16

LIBRARY
The three institutes of the Okazaki National Research Institutes share a common library· facility. The
library is a part of the main administration building and has a floor space of 2.500 m 2 .
The library has 9,350 books in Japanese and 30,050 in foreign languages. and subscribes to 237
Japanese and 446 foreign journals. Lending records, inventory and literature searches arecomputerized. The library is open 24 hours a day.

LODGING FACILITYThe Okazaki National Research Institutes maintain two lodging facilities. the Mishima Lodge andYamate Lodge. Mishima Lodge is a few minutes walk away; Yamate Lodge is less than 20
minutes. The lodges are for scientists and their families staying for fixed periods of time with theinstitutes. Some suites and bungalows are provided with kitchenette facilities. There is a modest
charge to help maintain the facilities.
Mishima Lodge has 54 single rooms. 4 twin rooms. 6 suites. and 10 bungalows for large families.
Yamate Lodge has 11 single rooms. 4 suites anq 2 family complexes.
On the campus there is a dining facility that is open Monday through Saturday.

17

THE CITY
The city of Okazaki, incorporated in 1916, is locat ed 30 kilometers
southeast of Nagoya, the fourth largest city in Japan. A high-speed
urban train con nects the two cities.
Okazaki, with a population of 275.000, is a typical medium-size cityin Japan and offe rs the convenience of urban life w hil e avo iding thedisadvantages of a large ci ty . Okazaki is the commercial as wel l as
cultura l center of the Mikawa (Th ree River) district with its ri chhistorical heritage. lyeyasu Tokugawa, the first Tokugawa Shogun,
was born here in 1542 and built a castle here. Th e origina l parapets
and moats and th e rebui lt castle still dominate the city as they did
500 years ago. When he establ ished the Shogunate in Edo (theformer name of Tokyo) in 1603, lyeyasu took a large contingent of
Mikawa Bushi (Mikawa Sam urai or professional wa rriors) with him.
Those M ikawa Bushi formed the nucleus of lyeyasu's new
admini stration.
With in a rad iu s of 10 kilometers from the city center are locatedMitsubishi Motor's Okazaki Plant. Toyota Motor's main production
fac il ities in Toyota city, and Sony's ultramodern Koda plant which
produces video tape/disc reco rd ers.

TRANSPORTATIONBY TRAIN
From Tokyo to Toyo-hash i : Two and ha lf hours by the Japan
Rai lway's (JR-Tokai) super-exp ress tra in (KODAMA or ECHO) The
train runs eve ry 30 min.

18

From Toyo-hashi to .Okazaki: Twenty five minutes by the Mei-tetsu(Nagoya Railway) express. Mei-tetsu's station in Okazaki is Higashi(or East) - Okazaki . The train run s every 20 to 30 min. This is themost conven ient route to come to Okazaki from Tokyo.
From Tokyo to Nagoya: Two hours by the JR's super-express train(HIKARI or LIGHTE NIN G) The train runs every 30 min.
From Kyoto/Osaka to Nagoya: One to two hours by the JR' s
super-express train (HIKAR I/KODAMA) Kin-tetsu (Kinki Nippon Railway) also se rves between Osaka/Nara and Nagoya.
From Nagoya to Okazaki: Thirty five minutes by the M ei-tetsu
express wh ich run s every 20 min.

BY AIR
Dom estic airlines serve Komaki. Nagoya, airport which is a 1-hour.
drive from Okazaki.

WEATHERIn Okazaki, temperature goes up to 30 degree cent1g rade insummer and down to a f ew degrees above the freezing point in th e
winter. May to June IS the rainy season and the spring (March toM ay) and fall (September to November) are most pleasant.

THE OKAZAKI CASTLE,
THE HOME OF THE FIRSTTOKUGAWA SHOGUN, IYEVASU.

19

DIRECTOR GENERALTOKINDO S. OKADA,

B. Sci. & D. Sci. (zoology, Kyoto Univ.) Researclil
Associate. Department of Zoology, Kyoto Univ. (1 954-59) . Macau Iley Fellow,
Univ. Edinburgh (1957 -59). Lecturer. Department of Zoology, Kyoto Univ.
(1960-61). and Associate Professor, (1962-66). Carnegie FeliGw, Department of Embryology, Carnegie Institution of Washington (1964-1965).
Professor, Department of Biophysics. Kyoto Univ. (1967 - 1984). Director
General. NIBB (1984- ), Professor Emeritus, Kyoto Univ.

PROFESSORS EMERITUS
NOBORU KAMIVA, B. Sci. (botany, Tokyo Imperial Univ.). D. Sci.
(botany, Univ. Tokyo) . J:.ecturer, Univ. Tokyo (1943-49). Professor. Osaka
Univ. (1949-77). Visiting Professor, Princeton lJniv. (1962-63). Visiting
Professor, State Univ. of NY at Albany (1969-70), Professor, NIBB
(1977-81). Professor Emeritus. NIBB. Mem.ber Japan Academy.
MASUTARO KUWABARA,

B. Sci. & D. Sci . (zoology, Hokkaido Imperial
Univ,.). Research Associate, Hokkaido Imperial Univ. (1933-43). Associate
Professor. (1944-49). Professor. Kyushu Univ. (1949-73). Dean, School of
Science (1964-66), Professor. Sophia Univ. (1973-77), Director General
NIBB (1977-83). President ONRI (1981-83). Professor Emeritus, NIBB.
Member NIBB Couhcile (1983- ).

VUKITO OOTA,

B. Sci . (botany, Tokyo Imperial Univ.) & D. Sci. (biology,
Nagoya Univ.). Assistant Professor. Biological lns ~itute . Nagoya Univ. (195061). Professor (1961-79) . Professor. NIBB (1979-83). Professor Emeritus,
NIBB.

PROFESSORSVASUHIRO ANRAKU.

Division of Cell Proliferation . B. Sci .. M. Sci . &Ph . D. (pharmaceutical sciences, Univ. Tokyo). Visiting Fellow , NIH (196567 ). Research Fellow, Stanford Univ . (1967 -68). Research Associate (1968).
Faculty of Pharmaceutical Sciences. Univ. Tokyo, Associate Professor

20(1970-76), Professor, Department of
Adjunct Professor. NIBB (1987- ).

Biology,

Univ. Tokyo (1976-).

GORO EGUCHI,

Division of Morphogenesis . B. Sci . & D. Sci. (biology,
Nagoya UnivJ Research Associate, Department of Biology, Nagoya Univ.
(1959-68). Associate Professor. Department of Biophysics. Kyoto Univ .
(1968-76). Professor, Institute for Molecular Biology, Nagoya Univ. (197684). Professor, NIBB (1983- ).

YOSHIHIKO FUJITA. Division of Bioenergetics. B.L.A. (libera l arts. Univ.
Tokyo). M. Sci. (biology, Univ. Tokyo) & D. Sci . (biochemistry, Univ. Tokyo).
Research Associate. In st. Appl. Microbial., Univ. Tokyo (1957 -67). Postdoctral Fellow, Univ. Texas (1962-64). Research Associate, Univ. Texas (1965).
Associate Professor, Ocean Res . lnst. Univ. Tokyo (1967 -77). Professor(1977 -1982). Professor. NIBB (1982- ), Acting Director. NIBB (Feb.-Sept.,
1984)
HIDEMASA IMASEKI. Division of Biological Regulation. B. Sci ., M. Sci.
& D. S~i . (botany, Univ. Tokyo) . Research Associate, Nagoya Univ.
(1959-69). Visiting Fellow. UCLA (1963-65). Associate Professor. Nagoya
Univ . (1969-79). Visiting Professor. Fairchild Tropical Garden (1972). Professor. Nagoya Univ. (1979-. ). Adjunct Professor. NIBB (1987- ).
KATSUHIKO MIKOSHIBA. Division of Behavior and Neurobiology. M.D .
& Ph . D. (physiology, Keio Univ. School of tyledicine), Instructor. Keio Univ.
Med. School (1973-74). Assistance Professor (1974-82). Associate Professor (1982-85). Postgraduate Fellow, Pasteur Institute (1976-77). Professor
Institute for Protein Research, Osaka Univ. (1985- ), Adjunct Professor.
NIBB (1986- ).
NORIO MURATA,

Division of Cellular Regulation. B. Sci ., M. Sci., & D.
Sci . (biochemistry, Univ. Tokyo). Research Associate. Department ofBiophysics and Biochemistry, Univ. Tokyo (1966-78) , Carnegie Fellow,
Department of Plant Biology, Carnegie Instit ution of Washington (1969-70).
Associate Prol essor, Department of Biology, Univ. Tokyo (1978-85) . Professor. NIBB (1985- ).

YOSHITAKA NAGAHAMA.

Division of Reproductive Biology. B. Sci ..
M. Sci. & D. Fish . (biology, Hokkaido Univ ). Postdoctoral Fellow, Univ. of
California. Berkeley (1972 - 74). Univ. of British Columbia (1974-76). Research Associate. Univ. British Columbia (1976-77). Associate ResearchEndocrinologist. Univ. of California. Berkeley (1977). Associate Professor.
NIBB (1977-86). Professor. NIBB (1986- ).

ASSOCIATE PROFESSORS

KEN-ICHI NAKA.

Division of Sensory Processing. B. Sei .. M . Sci. & Ph.
D. (biology, Kyushu Univ.) Visiting Fellow. NIH (1960-62). Research
Zoologist, UCLA (1962-63). Research Fellow. Univ. Cambridge (1963-64).
Staff Member. Shionogi Research Lab. (1964 - 67). Research Associate andSenior Research Associate. Calif. lnst. Tech . (1968-77). Professor, Departments of Physiology and Biophysics and Ophthalmology, UTMB (197f:l-79),
Professor, NIBB (1979- ). H.W. Rand Fellow (1985).

VOSHIRO SHIMURA.

Division of Cellular Communication . B. Sci ., M.
Sci. & D. Sci . (botany, Kyoto Univ.). Ph . D. (microbiology and molecularbiology. Rutgers Univ.). Research Assistant. Institute of Microbiology,
Rutgers Univ. (1958-1963). Postdoctral Fellow, Department of Microbiology,
the Johns Hopkins IJniv. School of Medicine (1963-65). Instructor (196568). Research Fellow. Research Institute for Microbiological Disease. Osaka
Univ. (1968-69). Associate Professor. Department of Biophysics. Kyoto
Univ. (1969 - 85), Professor (1985- ). Adj net Professor. NIBB (1986- ).

YOSHIAKI SUZUKI. Division of Cell Differentiation . B. Sci . & D. Sci .
(pharmaceut. sci., Univ. Tokyo) . Staff Member, NIH of Japan (1959-71).
Postdoctoral Fellow, Department of Embryology, Carnegie Institution of
Washington (1968-71 ). Senior Staff Member. NIH of Japan (1971-73), Staff
Member. Department of Embryology, Carnegie Institution of Washington(1973-78). Professor. NIBB (1978- ).

IKUO TAKEUCHI.

Division of Developmental Biology. B. Sci . & D. Sci .
(biology, Osaka Univ.). Ph. D. (biology, Princeton Univ.). Research Associate.
Department of Biology, Osaka Univ. (1955-1967). Research Fellow, Department of Embryology. Carnegie Institution of Washington (1959-1961).
Professor, Department of Botany, Kyoto Univ. (1967- ), Adjunct Professor.
NIBB (1985- ).

TSUYOSHI UCHIDA. Division of Cell Fusion. M.D. & Ph. D. (Osaka
Univ. Medical School), Research Associate of Research Institute for
M icrobial Diseases. Osaka Univ. (1967 -1975). Researcn Fellow of BiologicalLabs of Harvard Univ. (1 970 - 1972), Assoc iate Professor of ResearchInstitute of Microbial Deseases. Osaka Univ. (1 975 - 1982). Professor. Osaka
Univ. (1982- . ). Adjunct Associate Professor, NIBB (1978- ~ 982). Adjunct
Professor, NIBB (1985 - ).

KOHJI HASUNUMA. Radioisotope Facility. B. Sci. (biology, Univ. Tokyo).
M . Sci . & D. Sci. (botany, Univ. Tokyo). Research Associate, Univ. Tokyo(1971-79). Associate Professor. NIBB (1979 - ).

SHIGERU ITOH. Division of Bioenergetics. B. Sci .. M. Sci. &. D. Sci .
(biocherr.listry, Univ. Tokyo). Research Associate. Fac;;ulty of Sd., Kyushu
Univ. (1975 - 82). Assoeiate Professor. NIBB (1982- ).
MASAKI IWABUCHI.

Division of Developmental Biology. B. Sci .. M . Sci.
& D. Sci. (biology, Hokkaido Univ.). Research Associate. Hokkaido Univ.
(1960-1965). Research Associate. Hiroshima Univ. (1965 - 66). Research
Associate, Hokkaido Univ . (1967 -79). Lecture, Hokkaido Univ. (1979 - 82).
Associate Professor. Hokkaido Univ. (1982- ), Adjunct Associate Professor.
NIBB (1985- ).

TOSHIYUKI NAGATA.

Division of Cell Mechanism . B. Sci. (biology,
Univ. Tokyo). M. Sci. & D. Sci. (botany, Univ. Tokyo) . Research Associate,
Univ. Tokyo (1973- 79), Alexander von Humboldt Fellow. Max-Pianck-lnstitut
fur Biologie (1974-75). Research Associate. Nagoya Univ. (1980-83),
Associate Professor. NIBB (1983- ).

KENZO NAKAMURA. Division of Cellular Communication . B. Agr., M .
Agr. & D. Agr. (agricultural chemistry. Nagoya Univ .). Research Fellow.
Department of Biochemistry, State Univ. of New York at Stony Brook(1976- 79). Research Lecturer (1980-81 ). Researcher. Mitsubishi-Kasei Institute of Life Science (1981-83). Associate Professor. School of Agriculture.
Nagoya Univ. (1983- ). Adjunct Associate Professor. NIBB (1986- ).
HIDEAKI NAKASHIMA. Division of Cellular Regulation . B. Sci . & M . Sci .
(botany, Hiroshima Univ.). D. Sci . (botany, Nagoya Univ.) Research Associate. Nagoya Univ. (1969-80). Research Fellow (Postdoctoral), Univ. of
California at Santa Cruz (1979 - 80). Associate Professor, NIBB (1980 - ).

MASAHARU OGAWA.

Division of Behavior and Neurobiology. B. Soi . &M . Sci. (pharmaceutical sci, Osaka Univ.). Ph. D. (physiology, Kyoto Univ.
School of Medicine). Research Fellow. Kyoto Univ. School of Medicine(1969 - 1971). Instructor. Okayama Univ. School of Pharmaceutical Sci.

------------------------------------------------------------------------------2'1

(1971 - 1973). Inst-ructor." Kyoto U_niv. School of Medicine (1977 - 1979).
Associate Professor. Kochi Med. Sch. (1979 -· ). Adjunct Associate Professor. NIBB (1987 - ).

KENJI WATANABE. Division of Morphogeneis. B. Sci. M. Sci .. & D.
Sci .. (biology, Univ. Kyoto). Research Associate. Depa rtment of Anatomy,
Kyoto Prefectural Univ. (1973-80). Associate Professor. Department of
Anatomy, Fuku i Medical School (1980-86). Associate Professor. NIBB
(1986 - ).

MASARU YAMAIZlJMI. Division of Cell Fusion. M. D. (medicine. Kyoto
Univ.) & Ph. D. (virology, Osaka Un1v.). Research Assoc iate. Research

Research Institute for Microbial Diseases. Osaka Univ. (1977 - 79). Research).
Associate. NIBB (1979 -SHIGEYUKI KAWANO. Division of Cell Mechanisms. B. Sci. & M. Sci.
(biology, Okayama Univ) D. Sci. (biology, Tokyo Metropolitan Univ.).
Technical Staff. NIBB (1978-83). Resea rch Associate. NIBB (1983 - ).
TAKEO KISHIMOTO. Division of Reproductive Biology. B. Sci. (chemistry. Univ. Tokyo). M. Sci. & D. Sci. (zoology.
Associate. NIBB (1978- ).

Univ. Tokyo). Research

RYUJI KODAMA. Division of Morphogenesis . B. Sci. (biophysics andbiochemistry, Univ. Tokyo). M. Sci. & D. Sci. (molecular biology, Nagoya).
Univ.). Research Associate. NIBB (1983 -Institute for Microbial Diseases. Osaka Univ. ( 1975- 82). Research Fellow.
Department of B1ology, Ya le Univ. (1980). Research Associate. Institute for
Molecular and Cellular Biology, Osaka Univ. (1982). Associate Professor.
Institute for Molecu lar and Cell ular Biology. Osaka Univ. (1983 - ). Adjunct
Assoc1ate Professor. NIBB ( 1983 - ).

KENJI KOHNO . Division of Cell Fusion. B. Sci.. M. Sci . & D. Sci(microbiology, Univ. Tokyo). Research Associate. NIBB (1980 - ).

SHOZO YASUI . Division of Sensory Processing. B. Eng . . (aeronautics.

TAKAO KONDO. Division of Cellular Regulation. B. Sci. M . Sci. & D.

Univ. Tokyo). M. Sci. & Ph. D. (bioengineering Mass. lnst. Tech.). Staff
Toshi ba Re s. Lab. (1970 - 71). Re search Fellow. Calif. lnst. Tech. (1972 - 74).
Ass1stant Professor. UTMB (1976 - 79). Associate Professor. NIBB (1979 - ).

Sci. (biology, Nagoya Univ.). Research Associate. NIBB (1978-).

MAMORU MIMURO. Division of Bioenergetics. B. Sci .. M. Sci. & D.
Sci. (biology, Univ . Tokyo). Postdoctoral Fellow. Ocean Res. lnst. Univ.
Tokyo (1978 - 80). Research Associate. NIBB (1980 - ).

RESEARCH ASSOCIATES

MITSUE MIYAO. Divis1on of Cellu lar Regu lation. B. Sci .. M . Sci. & D.
Sci. (biophysics and biochemistry. Univ. Tokyo). Research Associate. NIBB
(1985 - ).

KIYOKAZU AGATA. Divis1on of Morphogenesis. B. Sci. & M . Sci.
(biophysics. Kyoto Univ) . Research· Associate. NIBB (1983 - ).
YOSHIO HAMADA. Tissue and Cell Cu lture Laboratory B. Sci. (biology,
Osaka Univ.), M . Sci. & D. Sci. (biophysics. Kyoto Univ.). Research
Assoc1ate. NIBB (1979 -).

EIKI HIDA. D1v1sion of Sensory Processmg . B. Sci. (mathematics. Nagoya
Un1v.) & M. Sci. (biophysica l engineering. Osaka Univ ). Research associate.
NIBB (1979 - ).

22

IKUO NISHIDA. Division of Cellular Regulation. B. Sci. & M. Sci.
(chemistry. Nagoya Univ.) . D. Sci. (coordinatedResearch Associate. NIBB (1985- ).

science.

Univ.

Tokyo).

KAZUO OGAWA. Division of Cell Mechanism. B. Sci .. M. Sci. & D. Sci.
(biology, Tokyo Metropolitan Univ.). Junior Researche r. Univ. Hawaii (1975).
Research Fellow. Calif. lnst. Tech. (1976). Research Associate. NIBB
(1979 - ).

MASAHIRO ISHIURA. Division of Cell Fusion. B. Sci. (biology, Kanazawa

KAORI OHKI . D1v1sion of Bioenergetics. B. Agr. (agriculture. Kyoto Univ ).

Un1v.).

M. Sci. & D. Sci. (biology, Kyoto Un1v.). Techn1cal Staff. Ocean Res. lnst.

M. Sci.

& D.

Sci. (biology,

Osaka

Un1vJ

Research Associate.

Univ. Tokyo (1975-82). Research Associate. NIBS (1982-).

Sci .. M. Sci. & D. Sci. (biology, Univ. Tokyo). Research Fellow, Univ. Tokyo.
(1974 - 78). Resea rch Associate, NIBS (1978 - ).

KIYOTAKA OKADA. Division of Cel lular Communication. B. Sci, M. Sci.
& D. Sci. (biophysics. Kyoto Univ.) . Research Associate. Univ. Tokyo(1975-82, 84 - 86). Research fel low, Department of Biochemistry andMolecular Biology. Harvard Univ. (1982-84). Research Associate, NIBS
(1986 -KOTARO YAMAMOTO. Division of Biological Re gu l a~ion. B. Sci. M.
Sci ., M . Sci & D. Sci. (botany, Univ. Tokyo). Predoctoral Fellow. Smithsonian
Institution (1977-79), Research Associate, NIBS (1980- ).

).

HIROKO SAKAl. Division of Sensory Processing. B.LA. MA (psychology, Int. Chri stian Unvi.) & D. Sci. (zoology, Kyoto Univ.). Research Associate.
NIBS (1979 - ).

INSTITUTE RESEARCHFELLOW

HIROKO SHIRAI.

Divi sion of Reproductive Biology. B. Sci. (biology,
Yokohama Municipal Univ.) & D. Sci (biology, Univ. Tokyo). Technical Staff.
Un1v. Tokyo (1966-77). Research Associate. NIBS (1977- L

TEIICHI FURUICHI. Division of Behavior and Neurobiology . B. Sci.

Yamagata Univ .), M. Sci. & D. Sci . (biology. Nagoya Univ.). Research
Associate. NIBS (1985 - ).

(biology, Shinshu Univ.), M. Sci & D. Sci. (biology, Tokyo Metropolitan Univ.).
Visiting Graduate Student. State Univ. of New Yo rk at Stony Brook(1983 - 86). Research Fellow, NIBS (1986 - ).

SHIGEHARU TAKIYA. Division of Cell Differentiation . B. Sci., M. Sci. & .

MASANORITOSHIHARU SUZUKI. Division of Cell Differentiation . B. Sci. (biology,

D. Sci. (biology, Hokkaido Univ.). Research Fellow. Hokkaido Univ. (1982 1983), Technical Staff. NIBS (1983 - 1984). Research Associate, (1985 ).

HIRANO. Division of Cel lula r Communication. B. Sci.
(biology, Kyoto lnst. Tech.). M. Sci. & Ph. D. (biophysics, Kyoto UnivJ
Research Fellow, NIBS (1987- ).

TAKAAKI TAMURA. Division of Behavior and Neurobiology. B. Sci.

KATSUMI TODA.

(hygiene, Kitasato Univ.). M. Sci. (agriculture. Kagawa Univ.) & D. Sci.
(medical science. Ke io UnivJ Research Associate, Keio Univ. Med. School(1977 - 86). Research Fellow, Univ. Louis Pa steur de St rasbourg (1984 - 86),
Re sea rch Associate. NIBS (1986 - ).

MASAO TASAKA.

Division of Developmental Biology. B. Sci. (biology,
Osaka Univ.). M . Sci . & D. Sci. (botany. Kyoto Univ.). Postdoctoral Fellow,
Kyoto Univ. (1980 - 1983). York Univ. (1983 - 84). Research Associate. NIBS
(1985 - ).

SATORU TOKUTOMI . Division of Biological Regulation . B. Sci., M. Sci.
& D. Sci. (biophysics, Kyoto Univ) Research Fellow. Kyoto Univ. (1978-80).
Research Associate, NIBS (1980 - ).
MASAKATSU WATANABE. Large-Scale Spectrograph Laboratory

B.

Division of Developmental Biology. B. Sci. M. Sci . &D. Sci. (botany. Hokkaido Univ.) Postdoc toral Fellow. M ax-Planck-Institute
fur Biochem ie (1981 - 85). Research Fellow, NIBS (1985 - ).

lECHNICAL DEPARTMENTS
STAFF
Head
HACHIRO HONDA. (Anjo Agricu ltura l and Forestry High School), Technical Staff, Nagoya Univ. (1953 - 78), Head. Technical Department, NIBS
(1978 - ).

23

Common Facility GroupHISAYA UEMURA, LaboratCD ry Glassware Facility. (pharmacology, Kitasato Univ.). Technical Staff, NIBB (1985- ).

Chief
HIROYUKI HATTORI. Center for Analytit;;al lnstrumer;Jts . B. Sci. (agricul~agoyature, Nagoya Univ.). Technical Officer,
Te!!:hnica l Staff. NIBB ( 1 ~79- ).

Ufliv. (1985-79).

Chief.

Research Support GroupSHINJI ADACHI,

Department of Developmental BioloQJy. B. Fish . (biology, Hokkaido Univ.). Technical Staff, NIBB (1980- ).

KANAKO FUNADERA. Radioisotope Facility. B. Sci. (agricLJI~ure. Kobe
Univ.). Technical Staff. NIBS (1985-

YUICHIRO ANDO, Department of Regulation Biology. B. Sci. (information~cience. Fukui Univ.). Technical Staff. NIBB (1980- ).

).

KAZUHIKO FURUKAWA.

Radioisotope Facility. B. Sci. (biology, Toho
Univ ). Technical Staff, NIBB (1979- ).

YOHKO FUJIM!JRA. Department of Regulation Biology. B. Sci. (biology,
Tokyo Metropolitan Univ ), Techmi!!:a l Stall, NIBB (1980- ).

HIROKO KAJIURA, Center for Analytical lmstruments. B. Sci. (chemistry.
Nagoya Univ.), Technical Staff, NIBB (1980-

S.OH

HIDAKA DeJ!lartment of Regulation
Nag.oya Univ ), Technical Staff, NIBB (198l-).

Biology.

B.

Sci.

(biology,).

MASAHIRO KAWAGUCHI.

Tissue and Cell Culture Laboratory. B. Sci.
(chemistry, Shizuoka Univ). Technical Staff, NIBB (1985- ).

HISASHI KOJIMA. Center for Analytical lnstuments. B. Sci. (industrial
chemistry, Nagoya Institute of Technology). Technical Stall, NIBB (1982- ).
KUBOTA. Large-Scale Spectrograph LaboratCDry. (radiocommunicat ion , Miya Fishery High School). Technical Staff. NIBB (1980-).

SHOICHI .HIGASHI,

Department of Regulation Biology. B. Sci. & M. Sci.
(agriculture, Mie University), Technical Staff. NIBB (1987- ).

MASAYO IWAKI. Department of Cell BioloQJy. B. Sci. (chemistry, Nara
Women's Univ.). Technical Staff, NIBB (1985- ).

MAMORUKAORU KATOU . Departmemt of Developmental Biology. (agriculture,
Shiga Prefecture Junior Col.). Technical Staff, NIBB (1985-).

YUKIE MIYAMOTO.

Radioisotope Facility. B. Sci. (agriculture, Kywshu
Univ). Technical Staff, NIBB (1981- ).

MIYUKI KATOU.

CHIEKO NANBA. Experimen tal Farm . (agriculture,
Junior Col.), Technical Staff. NIBB (1984- ).

AKIO MURAKAMI,

Shiga

Prefecture

MASAHIRO NASU, Laboratory Computer Facility (Meinan TechnicalHigh School). Technical Staff. NIBS (1982-

Univ.).

Department of Cell Biology. B. Sci. (biology, Waseda
Research Fellow, Univ. Tokyo (1978-81), Tecl;mical Staff, NIBB

(1981-).

).

TOSHIKI OHKAWA, Laboratory Glassware Facility. (Shimizu-minami HighSchool). Techn ical Staff. NIBB (1984-

Department of Developmental Biology. B. Sci. (aQJriculture, Shizuoka Univ.). Technical Staff. NIBB (1986- ).

SOICHI NAKAMURA, Department of Cell Biology. B. Sci. & M. Si!:i.
(biology, To~yo lnst. Tech.) , Technical Staff. NIBB (1979- ).

).
Department o~ Developmental Biology. B. Sci. (agricu lture, Tokyo Univ. of Agriculture), Technical Staff, NIBB (1985- ).

MAYUMI NASU,
FUMIE SETO. Center for Analytical Instruments. B. Sci. (agriculture,
Ag ricultures(1987 -

24

).

ana

Technology

of

Toky0

Univ.),

Tecmnical

Staff.

NIBBNORIKO SAKURAI. Department of Developmental Biology.
(agriculture, Meiji Univ.), Technical Staff. NIBB (1986- ).

B. Agr.

PROMOTION AND
NEW APPOINTMENTSASSOCIATE PROFESSORSTAKEO KISHIMOTO.
sor, NIBB (1S87 -WATARU MITSUHASHI.

Division of Biological Regulation . B. Sci ., M .
Sci ., & D. Sci. (bioiogy, Tokyo Metropolitan Univ.). Research Associate, NIBB
(1987- ).

INSTITUTE ~ESEARCHFELLOW

Division of Reproductive Biology. Associate Profes-).

TAKAHITO SUZUKI,

Division of Cell Proliferation . B. Sci. (plant science.
Univ. Tekyo), M . Sci. , & Pi'! . D. (plant science & bacterial genetics, Univ.
Tokyo) . Post-Ooctoral Fellow, Univ. Tokyo (1977 - 79). Institute Research
Fellow, NIBB (1979-81), Assistant Professor. Nagoya Univ. (1981- 83) and
Associate Professor (1987- ). Visiting Associate Professor, Michigan State
Univ. (1984-86) . Adjunct Associate Professor, NIBB (1987- ).

KOUJI UENO.

Division of Cell Differentiation . B. Sci. , M . Sci ., & Ph. D.
(pharmaceutical sciences. Univ. Tokyo). Research Associate, Univ. Tokyo(1981-87). Associate Professor. NIBB (1987 - ).

RESEARCH ASSOCIATESHIDETOSHI IIDA, Division of Cell Proliferation. 8. Sci . (biol ogy, lbaraki
Univ.). M . Sci ., 81 D. Sci ., (biophysics & bio11:hemistry, Univ. Tokyo) . Staff
Member, The Tokyo Metropolitan lns~ itute of Medical Science (1978-85),
Research Fellow. Dana-li'arber Cancer Institute. Harvard Medical School(1985 - 87). Research Associate, NIBB (1987- ).

VtJRIKO VAGAWA, Division of Cell Proliferation . B. Sci ., & M . Sci.
(biology, Niigata Univ.). & D. Sci . (botany, Univ. Tokyo) . Institute Research
Fellow. NIBB (1987- ).

NATI ONAL INSTITU TE FOR BAS IC BIOLOGYOKAZAK I NATIONAL RESEA RCH INS TI TUTES
Oka za k1. 4 44 JAPANTEL :TELEX:FAX:

I

0 564-54- 1111
453 7 475 KO KK EN J
0 564-53-7 4 00