Catalyzing Innovation and Charting theFuture of Healthy Longevity: Role of theNational Academy of Medicine
Victor J. Dzau, MDPresident, National Academy of Medicine
April 14, 2018
Keio Longevity Cluster Policy Dialogue

Decrease in global fertility rate
In 2050, ~16-17 % of global population (1.6 B people) will be 65+
In 2050, ~6% of global population will be under 5The “Silver Tsunami”
In both industrialized and developing countries, the rateof population aging stands to fundamentally impact howfamilies, communities, societies, industries andeconomies function••••••Infirmities: patterns and prevalence
Health care delivery and financing
Family structure and relationships
Social infrastructure
Social insurance and retirement programs
Workforce size and composition

Aging and Healthy Longevity:
A Global Grand Challenge
Global Aging Preparedness Index (CSIS and GlobalAge Watch) Results:•Overall, very mixed levels of preparedness globally•

While some countries and governments havebegun to act and are starting plan for the long-term,
too many have not•Preparing financially, socially, and scientificallyfor longer lifespans is a global imperative

Source: Analyses from the Center for Strategic and International Studies and Global Age
Watch

Awards and Prizes•

Catalyze breakthrough ideas that will
expand the healthspan into later life.
Convergence of biologic, social,engineering sciences and technologies.

•Achieve transformative and scalable
innovation in healthy aging and longevity.

•Build a broad ecosystem of support.

Global Roadmapfor Healthy Longevity
Comprehensive assessment of thechallenges and opportunities
presented by global aging, as well as
the promising solutions andnecessary directions for improving,health, productivity, and quality oflife

How do we effectively prepare and better equip
ourselves for aging and healthy longevity globally?
PERSONAL, SOCIAL, ECONOMIC &ENVIRONMENTAL DETERMINANTS

CLINICAL MEDICINE & HEALTHSCIENCE, TECHNOLOGY &DELIVERY SYSTEMSINNOVATIONPOLICY & PRACTICEGlobal Roadmap for Healthy Longevity

Global Roadmap Planning Group Members
Sarah Barber, WHO Kobe Centre

Sharon Inouye, Harvard Medical School*

Michael Birt, Blue Triangle Health*Paul Irving, Milken Institute Center for theFuture of Aging

Laura Carstensen, Stanford University

Christine Cassel, Kaiser Permanente School Joseph Kvedar, Partners Healthcareof Medicine
Keith Leonard, Unity
Sally Davies, Chief Medical Officer forEngland

Hiroki Nakatani, Keio University

Deborah DiSanzo, IBM Watson Health

Lewis Sandy, UnitedHealth Group

Victor Dzau, National Academy of Medicine*

Kamili Wilson, AARP

Linda Fried, Columbia University

John Wong, National University Health
System, Singapore

Jeffrey Halter, University of Michigan andNational University of Singapore

Richard Hodes, National Institute on Aging* Member of Steering Committee

Jack Rowe, Columbia University

Tachi Yamada, Frazier Healthcare Partners*
Charlotte Yeh, AARP Services, Inc.

Extending the Healthspan:
Opportunities in Science and Technology• By delaying the biological processes associated withaging, we could prevent debilitating illness and disease,and loss of function• Several areas of promising research that havedemonstrated that biological aging is, in fact,modifiable—and that, in some cases, health and/or
lifespan can be extended• Using technology to transform the way we age• Technology can help ease the activities of daily living
and improve the quality and accessibility of healthcare
for the elderly

Research and Technology to Transform Aging
Research on longevity andhealthspan:• Senescent cells and telomere
dysfunction

Current and future technologies:• Emergency responsependants• Telehealth• Mitochondrial DNA damage
and dysfunction• Remote patient monitoring• Autophagy• Robot care givers andcompanions• Cellular regeneration• Longevity genes• Molecular pathways (mTOR,
NAD precursors and sirtuinactivators)• Epigenome / epigenetic clock• Wearable robotic systems andexoskeletons• Smart homes• Autonomous vehicles• Virtual reality• Artificial intelligenceDespite Progress, More is Needed• Aging research is underfunded– US: Only 5% of NIH budget in 2017 went to aging research• one quarter of that going to support cancer research and a third offunding for heart disease.

• Aging research is focused mainly on– Geriatric care
– Biology of model organisms• Innovation is targeted toward younger populations• Need to make aging research cool
• Need to jumpstart the field and bring together
different disciplines in convergence• Huge market

Challenge Prizes and Awards
The art and science of pushing and pulling innovation

Prize Program Design Committee
Tachi Yamada, M.D. (Chair)
Frazier Healthcare Partners

H. Robert Horvitz, Ph.D.
Massachusetts Institute of TechnologyNancy E. Adler, Ph.D.
University of California, San Francisco

Roderic Pettigrew, M.D., Ph.D.
National Institute of Biomedical Imaging
and Bioengineering

Mark C. Fishman, M.D.
Harvard University
Diane E. Griffin, M.D., Ph.D.
Johns Hopkins University

Marc Hodosh
Hodosh Productions
Former owner/co-creator, TEDMED
Edward W. Holmes, M.D.
Sanford Consortium for Regenerative
Medicine

Keith Powers
Engaged Partners
Jack Rowe, M.D.
Columbia University
Mark Walport FRS, FRCP, FRCPath,
FMedSci
Government Chief Scientific Adviser, United
Kingdom

Anthony Joonkyoo "Joon" Yun, M.D.
Palo Alto Investors, LLC

NAM Healthy Longevity Prizes and Awards• Catalyze breakthrough ideas and research that will expand thehealthspan into later life.

• Achieve transformative and scalable innovation in healthy aging andlongevity by translating evidence into action.
• Build a broad ecosystem of support. Globally, engage new minds to enter
the field and work together including scientists, engineers, innovators,entrepreneurs, health leaders, policy makers, and the public.

Global Competition: Design Framework

Inducement prize
modeled after theX-Prize

Regional competitions

A Vision for Healthy Longevity

Source: Yeoh, E.K. and L.H.Y. Angel, 2017

Thank you

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