大学共同利用機関法人
自然科学研究機構

基礎生物学研究所

外部点検評価報告書

2013

目

次

はじめに………………………………………………………………………………………… １
１．基礎生物学研究所 平成25年度実績の概要と将来計画 ……………………………… ３
２．基礎生物学研究所の概要………………………………………………………………… 23
３．基礎生物学研究所外部点検評価会議 議事録 ………………………………………… 43
４．外部点検評価アンケート結果………………………………………………………… 103
５．発表論文資料
１）2013-2011 発表論文リスト ……………………………………………………… 131２）2013-2011 プレスリリースと新聞報道 ………………………………………… 157ࡣࡌࡵ࡟
 ⮬↛⛉Ꮫ◊✲ᶵᵓ࣭ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᖹᡂ㸰㸳ᖺᗘእ㒊Ⅼ᳨ホ౯ሗ࿌᭩ࢆ
࠾㏦ࡾࡋࡲࡍࠋ ᖹᡂ㸰㸳ᖺᗘࡣ⏕࿨⛉Ꮫ◊✲⪅࡟࡜ࡗ࡚ࠊ◊✲୙ṇၥ㢟࡟᫂ࡅᬽࢀࡓ≉␗࡞ᖺᗘ࡜࡞ࡾࡲࡋࡓࠋᮾி኱Ꮫ࡟࠾ࡅࡿ኱㔞ㄽᩥ୙ṇၥ㢟ࡣࠊ㸰ᖺࡢㄪᰝࢆ⤒࡚୰㛫ሗ࿌ࡀฟࡉࢀࠊ᪥ᮏศᏊ⏕≀Ꮫ఍ࡣᖺ఍࡛ࡇࡢၥ㢟ࢆ୰ᚰ࡟◊✲୙ṇ࡟㛵ࡍࡿ㛗᫬㛫ࡢࢩ࣏ࣥࢪ࣒࢘ࢆ㛤ࡁࡲࡋࡓࠋ୍᪉ࠊ⮫ᗋ◊✲࡛ࡣࠊ◊✲⪅࡜〇⸆఍♫ࡢ୙㐺ษ࡞⒵╔ࢆ⫼ᬒ࡟ࠊ⮫ᗋヨ㦂࡟࠾ࡅࡿࢹ࣮ࢱᨵࡊࢇࡀḟࠎ࡜᫂ࡽ࠿
࡟࡞ࡗ࡚࠸ࡲࡍࠋࡉࡽ࡟ᖹᡂ㸰㸴ᖺ㸯᭶࡟⌮໬Ꮫ◊✲ᡤⓎ⏕࣭෌⏕⛉Ꮫ⥲ྜ◊✲ࢭࣥࢱ࣮࠿ࡽNatureㄅ࡟Ⓨ⾲ࡉࢀࡓࠊ࠸ࢃࡺࡿSTAP⣽⬊࡟ࡘ࠸࡚ࡢ㸰⦅ࡢㄽᩥ࡟ࡣࠊᵝࠎ࡞୙ṇࡢᏑᅾࡀᙉࡃ␲ࢃࢀࠊㄽᩥࡣྲྀࡾୗࡆࡽࢀࡿ࡜ࡇࢁ࡜࡞ࡾ
ࡲࡋࡓࠋSTAP⣽⬊஦᱌ࡣⓎ⾲ᙜึࡢ⳹ࠎࡋ࠸࣐ࢫࢥ࣑ሗ㐨ࡶ࠶ࡾࠊ኱ࡁ࡞♫఍ၥ㢟࡜໬ࡋࡲࡋࡓࠋ
 ࡇ࠺ࡋࡓ㦁ືࡀࠊ୍⯡ࡢேࠎ࡟ࠊㄽᩥᰝㄞࡢ௙⤌ࡳ࡞࡝ࠊࡇࢀࡲ࡛↓⦕࡛࠶ࡗࡓ⛉Ꮫ◊✲ࡢୡ⏺ࡢ୍➃ࢆ▱ࡗ࡚ࡶࡽ࠺ዎᶵࢆ୚࠼࡚ࡃࢀࡓ࡜࠸࠺⓶⫗࡞஦ᐇࡣ࠶ࡾࡲࡍࡀࠊ㐃᪥ࡢࡼ࠺࡟ሗ㐨ࡉࢀࡿ୙ṇ␲ᝨࡀࠊ⛉Ꮫ◊✲࡬ࡢಙ㢗ࢆ኱ࡁࡃയࡘࡅ࡚ࡋࡲࡗࡓࡇ࡜ࡣ㛫㐪࠸࠶ࡾࡲࡏࢇࠋᇶ⏕◊࡛ࡶ඲ဨࡀ௒ࡲ࡛௨ୖ࡟あࢆṇࡋࠊ⛉Ꮫ⪅࡜ࡋ࡚ࡢ⾜ືつ⠊ࢆᏲࡗ࡚◊✲ࢆⓎᒎࡉࡏ࡚࠸࠿࡞ࡅࢀࡤ
࡞ࡾࡲࡏࢇࠋࢿ࢞ࢸ࢕ࣈ࡞஦㇟࡟ࡶᩍカࡣྵࡲࢀ࡚࠸ࡲࡍࠋ౛࠼ࡤࠊWeb࡛බ㛤ࡉࢀ࡚࠸ࡿᩥ❶ࢆ⮬ศࡢ᭩ࡁ≀࡟ࢥࣆ࣮࣮࣌ࢫࢺࡍࡿࡇ࡜ࡢྍྰ࡟ࡘ࠸࡚ࠊ኱
Ꮫ㝔⏕ࡢୡ௦࡜◊✲ᣦᑟࡍࡿ❧ሙ࡟࠶ࡿୡ௦࡜࡛ࡣឤぬ࡟኱ࡁ࡞㝸ࡓࡾࡀ࠶ࡿࡇ࡜ࡀぢ࠼࡚ࡁࡲࡋࡓࠋࡇࡢ஦ᐇࡣ௒ᚋࡢᩍ⫱࡟ά࠿ࡉࢀࡿᚲせࡀ࠶ࡾࡲࡍࠋ
ࡲࡓࠊ࡞࠿࡞࠿㞴ࡋ࠸ࡇ࡜࡛ࡍࡀࠊ◊✲㈝ࡢ⋓ᚓ࡞࡝ࡢ┠ⓗࡢࡓࡵ࡟◊✲ࡀ๓ࡢࡵࡾ࡟࡞ࡾࡍࡂ࡚࠸࡞࠸࠿ࠊᖖ࡟⮬ไࡢᚰࢆಖࡕ⥆ࡅࡿࡇ࡜ࡶ㔜せ࡛ࡍࠋ ࡑࡢࡼ࠺࡞ᖹᡂ㸰㸳ᖺᗘ࡟⾜ࢃࢀࡓ⚾ࡓࡕࡢάືࢆᮏ෉Ꮚ࡟ࡲ࡜ࡵ࡚ࡈሗ࿌
ࡋࡲࡍࠋᙜヱᖺᗘࡶࠊᇶ♏⏕≀Ꮫࡢඛᑟⓗ࡞◊✲ࢆ᥎㐍ࡍࡿ࡜࡜ࡶ࡟ࠊ኱Ꮫඹ
ྠ฼⏝ᶵ㛵࡜ࡋ࡚ࠊඹྠ฼⏝◊✲࣭ᅜ㝿㐃ᦠ࣭᪂㡿ᇦࡢ㛤ᣅ࣭ⱝᡭ◊✲⪅ࡢ⫱ᡂࡢㅖ஦ᴗ࡟ຊࢆᑾࡃࡋ࡚ࡲ࠸ࡾࡲࡋࡓࠋ≉グࡍ࡭ࡁࡇ࡜ࡀࡽ࡜ࡋ࡚ࡣࠊ⮬↛





−1−

⛉Ꮫ◊✲ᶵᵓࡢ◊✲኱Ꮫᙉ໬ಁ㐍஦ᴗࡢ୍⎔࡜ࡋ࡚ࠊᖹᡂ㸰㸳ᖺ㸯㸮᭶࡟ᇶ⏕◊࡟◊✲ຊᙉ໬ᡓ␎ᐊࢆⓎ㊊ࡉࡏࡓࡇ࡜ࡀ࠶ࡾࡲࡍࠋᗈሗࡸᅜ㝿㐃ᦠ࡞࡝ࡢά
ືࢆ୍ࡘࡢ⤌⧊࡟㞟⣙ࡋࠊᖹᡂ㸰㸴ᖺ㸵᭶⌧ᅾࠊୖ㔝๪ᡤ㛗ࢆᐊ㛗ࠊすᮧ≉௵ᩍᤵࢆ๪ᐊ㛗࡜ࡋࠊ㸳ྡࡢURA University Research Administrator ࢆ᧦ࡍࡿయไ
ࡀ࡛ࡁ࠶ࡀࡗ࡚࠸ࡲࡍࠋࡇࡢ⤌⧊ࢆ᭱኱㝈ά⏝ࡋࠊ◊✲ᡤࡢ◊✲ຊྥୖࡢࡓࡵ
ࡢᇶ┙ᩚഛࢆຊᙉࡃ᥎㐍ࡋ࡚࠸ࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ ᖹᡂ㸰㸳ᖺᗘࡢᇶ⏕◊ࡢάືࢆᐈほⓗ࡞║࡛ホ౯ࡋ࡚㡬ࡃࡓࡵࠊᖹᡂ㸰㸴ᖺ㸲᭶࡟㐠Ⴀ఍㆟ࡢᡤእጤဨ㸰ྡࠊ๓ᡤእጤဨ㸯ྡࠊ㐠Ⴀ఍㆟ጤဨ௨እࡢᏛ㆑⤒㦂⪅㸰ྡࡢ᪉ࠎ࡟࠾㞟ࡲࡾ㢪࠸ࠊእ㒊Ⅼ᳨ホ౯఍㆟ࢆ㛤࠸࡚ᚷ៸ࡢ࡞࠸ࡈពぢࢆఛ࠸ࡲࡋࡓࠋࡲࡓࠊ㐠Ⴀ఍㆟ࡢᡤእጤဨ࡟ࠊᖹᡂ㸰㸳ᖺᗘࡢ◊✲ᡤࡢάື࡟
ࡘ࠸࡚࢔ࣥࢣ࣮ࢺᙧᘧ࡛ホ౯࡜ᥦゝࢆ࠾㢪࠸ࡋࡲࡋࡓࠋᮏ෉Ꮚ࡟ࡣࡑࢀࡽࡢグ㘓ࡀྵࡲࢀ࡚࠸ࡲࡍࠋ㡬ᡝࡋࡓಶࠎࡢࡈពぢ࡟ᑐࡋ࡚ࡢᑐᛂࢆ༑ศ࡟᳨ウࡋࠊ┠๓࡟㏕ࡗ࡚ࡁࡓ➨୕ᮇ୰ᮇィ⏬ࡢ⟇ᐃ࡞࡝ࠊ௒ᚋࡢ◊✲ᡤࡢ㐠Ⴀ᪉㔪࡟཯ᫎࡉࡏ࡚࠸ࡃᡤᏑ࡛ࡍࠋ ᖹᡂ㸰㸳ᖺᗘእ㒊Ⅼ᳨ホ౯ሗ࿌᭩ࢆࡈ୍ㄞࡃࡔࡉࡾࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㐠Ⴀ࡜άື࡟ࡘ࠸࡚ࡈ⌮ゎ࡜ࡈᨭ᥼ࢆ㡬ࡅࢀࡤࡲࡇ࡜࡟࠶ࡾࡀࡓࡃᏑࡌࡲࡍࠋࡉ
ࡽ࡞ࡿࡈពぢࡶ኱࠸࡟Ḽ㏄࠸ࡓࡋࡲࡍࠋ
ᖹᡂ㸰㸴ᖺ㸵᭶ᇶ♏⏕≀Ꮫ◊✲ᡤᡤ㛗 ᒣᮏṇᖾ







−2−

１．基礎生物学研究所 平成 25 年度実績の概要と将来計画

−3−






ᇶ♏⏕≀Ꮫ◊✲ᡤᖹᡂ㸰㸳ᖺᗘᐇ⦼ࡢᴫせ࡜ᑗ᮶ィ⏬






㸯㸬ᖹᡂ㸰㸳ᖺᗘᐇ⦼ࡢᴫせ
, Ꮫ⾡◊✲ࡢ᥎㐍

,, ඹྠ฼⏝࣭ඹྠ◊✲ࡢ᥎㐍

,,,ᅜ㝿㐃ᦠ࡜ᗈሗάືࡢᒎ㛤



,9 ᪂㡿ᇦࡢ㛤ᣅ



9 ⱝᡭ◊✲⪅ࡢ⫱ᡂ

㸰㸬ᑗ᮶ィ⏬㸦኱つᶍ◊✲ィ⏬ࠊᴫ⟬せồ㸧
㸱㸬◊✲ຊᙉ໬ᡓ␎ᐊࡢ᪂タ

−5−㸯㸬ᖹᡂ㸰㸳ᖺᗘᐇ⦼ࡢᴫせ,Ꮫ⾡◊✲ࡢ᥎㐍ᇶ♏⏕≀Ꮫ◊✲ᡤ㈨ᩱ 3㸨࡛ࡣࠊ⏕≀⌧㇟ࡢᇶᮏཎ⌮ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ᣦࡋࠊ⣽⬊⏕≀ᏛࠊⓎ⏕⏕≀Ꮫࠊ⚄⤒⏕≀Ꮫࠊ㐍໬ከᵝᛶ⏕≀Ꮫࠊ⎔ቃ⏕≀Ꮫ➼ࡢᇶ┙◊✲୪ࡧ࡟ඹྠ฼⏝◊✲ࢆ᥎㐍ࡋࠊᩘከࡃࡢඃࢀࡓ◊✲ᡂᯝࢆୖࡆࡓࠋ◊✲ࡢ㉁ࡢ㧗ࡉࡣࠊᶵ㛵ูㄽᩥᘬ⏝ᗘᣦᩘࠊᙳ㡪ຊࡢ㧗࠸㞧ㄅ࡬ࡢㄽᩥⓎ⾲ᩘࠊ➇தⓗ㈨㔠⋓ᚓ≧ἣ➼࡟♧ࡉࢀ࡚࠸ࡿ㈨ᩱ 3ࠋ ᖹᡂ  ᖺᗘࡢ୺࡞◊✲ᡂᯝ࡜ࡋ࡚ࠊ௨ୗࡢࡶࡢࡀᣲࡆࡽࢀࡿ㸨㸨ࠋ㸦㸧ෆ࡟Ⓨ⾲ㄽᩥ࡜ࣉࣞࢫ࣮ࣜࣜࢫ᪥௜ࢆ௜ࡋࡓࠋձ᪂ୡ⏺ࢨࣝࡢ࣐࣮ࣔࢭࢵࢺࡢ኱⬻⓶㉁࡛ࡢ║ඃ఩ᛶ࣒࢝ࣛࡢᏑᅾࢆ☜ㄆࡋࡓ㸦Nakagami, Y., et al. Front. Neural Circuits. 7,
43. 2013.5.9㸧ࠊղᗂⱝ࣍ࣝࣔࣥ㢮ఝ≀㉁ࡀ࣑ࢪࣥࢥࡢᛶࢆᨩ஘ࡍࡿ௙⤌ࡳࢆゎ᫂ࡋࡓ㸦Miyakawa, H., et al. Nature Commun. 4, 1856. 2013.5.21㸧ࠊճගྜᡂ࡟࠾࠸࡚㐣๫࡞ග࢚ࢿࣝࢠ࣮ࢆᾘཤࡍࡿᐇయ࡛࠶ࡿගྜᡂࢱࣥࣃࢡ㉁㉸」ྜయࢆⓎぢࡋࡓ㸦Tokutsu, R., and Minagawa, J. Proc. Natl. Acad. Sci. USA110, 10016-10021. 2013.5.28㸧ࠊմ⾑⟶ෆ⓶⣽⬊࡛ࡢ㑇ఏᏊⓎ⌧ࢆ㸯⣽⬊࡛ࣞ࣋ࣝࢥࣥࢺ࣮ࣟࣝࡍࡿࡇ࡜࡟ᡂຌࡋ
ࡓ㸦Kimura, E., et al. Thromb. Vasc. Biol. 33, 1264-1270. 2013.5.31㸧ࠊյ᳜≀⣽⬊ࡢ⣽⬊ศ⿣࡟࠾࠸࡚㝸⭷ᙧᡂయࡀᚤᑠ⟶࡟⦅ࡲࢀ࡚ᙧసࡽࢀࡿ㐣⛬ࡢほᐹ࡟ᡂຌࡋࡓ
㸦Murata, T., et al. Nature Commun. 4, 1967. 2013.6.17㸧ࠊնཷᐜయᆺࢱࣥࣃࢡ㉁ࢳࣟ
ࢩࣥ⬺ࣜࣥ㓟໬㓝⣲㸦RPTP㸧ࡢ R3 ࢧࣈࣇ࢓࣑࣮ࣜࡀࠊከᩘࡢཷᐜయᆺࢱࣥࣃࢡ㉁ࣜࣥ㓟໬㓝⣲㸦RPTK㸧ࢆᇶ㉁ศᏊ࡜ࡋࠊࡑࢀࡽࡢάᛶࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࢆⓎ
ぢࡋࡓ㸦Sakuraba, J., et al. J. Biol. Chem. 288, 23421-23431. 2013.7.8㸧ࠊշ࣐࢘ࢫ⬇ࡢཎ⭠㝗ධ㐠ືࢆࣛ࢖ࢺࢩ࣮ࢺ㢧ᚤ㙾ࢆ⏝࠸࡚௒ࡲ࡛࡟࡞࠸㧗᫬㛫ゎീᗘ࡛㛗᫬㛫ほᐹࡍࡿࡇ࡜࡟ᡂຌࡋࡓ㸦Ichikawa, T., et al. PLoS ONE 8, e64506. 2013.7.16㸧ࠊոⴥ⥳యࢤࣀ࣒ࡢാࡁࡀࠊⴥ⥳యࡢⓎ㐩ࡔࡅ࡛࡞ࡃࠊⴥࡢᙧࢆỴࡵࡿୖ࡛ࡶ㔜せ࡞ᙺ๭ࢆᢸ࠺ࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸦Tameshige, T., et al. PLoS Genetics 9, e1003655.
2013.7.26㸧ࠊչ࣐࣓⛉᳜≀ࡢ᰿⢏ࡢᩘࢆไᚚࡍࡿࢩࢢࢼࣝศᏊࡢᵓ㐀ࢆゎ᫂ࡋࡓ㸦Okamoto, S., et al. Nature Commun. 4, 2191. 2013.8.12㸧ࠊպ᳜≀ࡢᡂ㛗࡟ᚲせ࡞࢔ࣛࣅࣀ࣮ࢫ௜ຍ⢾ࢱࣥࣃࢡ㉁⩌ࢆࡘࡃࡾࡔࡍ㓝⣲ࢆⓎぢࡋࡓ㸦Ogawa-Ohnishi, M.,
et al. Nature Chem. Biol. 9, 726-730. 2013.9.16㸧ࠊջ࢔ࣇࣜ࢝ࢶ࣓࢚࢞ࣝ⬇ࡢཎ⭠㝗ධ࡟࠾࠸࡚ඛ⾜୰⬇ⴥࡢཬࡰࡍຊࢆィࡋࠊᙧసࡾ࡟࠾ࡅࡿᙺ๭ࢆ♧ࡋࡓ㸦Hara, Y.,

et al. Dev. Biol. 382, 482-495. 2013.10.4㸧ռࣂ࣮ࢳࣕࣝࣜ࢔ࣜࢸ࢕ᢏ⾡ࢆά⏝ࡋࡓ㸨ᮏ෉Ꮚࡢ P 25 ௨㝆࡟ᥖ㍕ࡋࡓ㈨ᩱࢆࡈཧ↷ୗࡉ࠸ࠋ㸨㸨 ᮏ෉Ꮚࡢ P157 ௨㝆ࢆࡈཧ↷ୗࡉ࠸ࠋ−6−⾜ືゎᯒᐇ㦂࡟ࡼࡾࠊ࣓ࢲ࢝ࡣయࡢືࡁࡢࣃࢱ࣮ࣥ࡟ࡼࡗ࡚௰㛫ࢆᘬࡁᐤࡏ࡚࠸
ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸦Nakayasu, T., and Watanabe, E. Animal Cognition 2013 Oct. 20.
2013.12.9㸧ࠊս࣓ࢲ࢝ࡢ࢜ࢫᑼ㫅࡟࠾࠸࡚࢔ࣥࢻࣟࢤࣥࡀ஧ḟᛶᚩⓎ⌧ࢆไᚚࡍࡿ
௙⤌ࡳࢆゎ᫂ࡋࡓ㸦Ogino, Y., et al. Endocrinology 2013 Nov. 18. 2013.12.12㸧ࠊվ㟋㛗㢮኱⬻⓶㉁࡟࠾ࡅࡿ㡿㔝≉␗ⓗ࡞㑇ఏᏊⓎ⌧ࡀࠊ㑇ఏᏊࡢࣉ࣮ࣟࣔࢱ࣮㡿ᇦࡢ࣓ࢳࣝ໬࡜࣓ࢳࣝ໬ DNA ⤖ྜࢱࣥࣃࢡ㉁࡟ࡼࡗ࡚ไᚚࡉࢀ࡚࠸ࡿࡇ࡜ࢆゎ᫂ࡋࡓ
㸦Hata, K., et al. J. Neurosci. 33, 19704-19714. 2013.12.19㸧ࠊտ㓟໬ࢲ࣓࣮ࢪࢆཷࡅࡓ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ࣮࢜ࢺࣇ࢓ࢪ࣮࡟ࡼࡗ࡚㑅ᢥⓗ࡟ศゎࡉࢀࡿࡇ࡜ࢆゎ᫂ࡋࡓ
㸦Shibata, M., et al. Plant Cell 25, 4967-4983. 2013.12.25㸧ࠊր࢜ࢪࢠࢯ࢘ࡢ㑇ఏᏊ᧯స࡟ึࡵ࡚ᡂຌࡋࠊ᳜≀ࡢ㐠ືࡢ௙⤌ࡳゎ᫂࡬ࡢᇶ♏ᢏ⾡ࢆ☜❧ࡋࡓ㸦Mano, H., etal. PLoS ONE 9, e88611. 2014.2.12㸧ࠊց⥙⭷࡛㡿ᇦ≉␗ⓗ࡟Ⓨ⌧ࡍࡿ SPIG1 㑇ఏᏊࡀࢥ࣮ࢻࡍࡿࢱࣥࣃࢡ㉁ࡀࠊ⚄⤒ࢩࢼࣉࢫྍረᛶࡢㄪ⠇࡟㛵ࢃࡿ⬻⏤᮶⚄⤒ᰤ㣴ᅉᏊࡢάᛶ໬ࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࢆⓎぢࡋࡓ㸦Suzuki, R., et al. J. Neurosci. 34,
3429-3442 2014.2.26㸧ࠊւⰼࡢⰍ⣲ྜᡂ࡟㛵ࢃࡾࠊⰼࡢⰍࢆ⃰ࡃࡍࡿࢱࣥࣃࢡ㉁ EFPࢆⓎぢࡋࡓ㸦Morita, Y., et al. Plant J. 2014 Mar. 14. 2014.3.14㸧ࠊփගྜᡂ཯ᛂㄪ⠇ࡢ௙⤌ࡳ “ࢫࢸ࣮ࢺ㑄⛣”ࡢᶵᵓࢆゎ᫂ࡋࡓ㸦Nagy, G., et al. Proc. Natl. Acad. Sci. USA
2014 Mar. 17. 2014.3.18㸧

−7−,,ඹྠ฼⏝࣭ඹྠ◊✲ࡢ᥎㐍㈨ᩱ 㹎
㸯㸧⏕≀ᶵ⬟᝟ሗศᯒᐊ㸦⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮㸧㈨ᩱ 㹎 ᇶ♏⏕≀Ꮫ◊✲ᡤඹྠ฼⏝◊✲ࡢ୍⎔࡜ࡋ࡚ࠕḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮ඹྠ฼
⏝ᐇ㦂ࠖࢆ≉௵෸ᩍᤵࡢࢧ࣏࣮ࢺࡢࡶ࡜ࠊ◊✲ᡤෆእࡢ◊✲⪅࡜࡜ࡶ࡟  ௳ࡢඹྠ◊✲ࢆᐇ᪋ࡋࡓࠋඹྠ฼⏝◊✲ࡢᡂᯝ࡜ࡋ࡚ඹⴭㄽᩥࢆ  ሗⓎ⾲ࡋࡓࠋࡲࡓࠊ ✀㢮  ྎ࡟ࡢࡰࡿከᩘࡢඹ㏻ᶵჾࢆ⟶⌮࣭㐠Ⴀࡍࡿࡔࡅ࡛࡞ࡃࠊࡇࢀࡽࡢᶵჾ
ࢆ᭷ຠ࡟฼⏝ࡍࡿࡓࡵ࡟ศᏊ⏕≀Ꮫ࠿ࡽࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ࡟Ώࡿᖜᗈ࠸ຓゝࢆ⾜ࡗࡓࠋࢤࣀ࣒࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ࣭ࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫ㈨ᩱ 㹎㸦㸰ᅇ㛤ദ㸧ࡣᐇ㦂⏕≀Ꮫ⪅ࡀ࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫࡢᇶ♏ࢆᏛ࡭ࡿ௚࡟౛ࡢ࡞࠸ࢥ࣮ࢫ࡜ࡋ࡚ዲホࢆ༤ࡋࡓࠋ
㸰㸧ගᏛゎᯒᐊ㸦⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮㸧㈨ᩱ㹎 ኱ᆺࢫ࣌ࢡࢺࣟࢢࣛࣇඹྠ฼⏝ᐇ㦂ㄢ㢟௳࡟ຍ࠼ࠊᖺᗘࡼࡾタ⨨ࡋࡓ㉥እ࣮ࣞࢨ࣮㑇ఏᏊⓎ⌧ㄏᑟ㢧ᚤ㙾㸦IR-LEGO㸧ࢆ⏝࠸ࡓඹྠ◊✲ㄢ㢟௳࡞࡝ྜィ௳ࡢඹྠ฼⏝◊✲ࢆᐇ᪋ࡋࡓࠋᡤෆእࡢ◊✲⪅࡬ࡢ㢧ᚤ㙾➼ࡢඹ⏝ࡢࢧ࣏࣮ࢺ
ࢆࡣࡌࡵࠊࢸࢡࢽ࢝ࣝࢭ࣑ࢼ࣮ࡢ㛤ദࠊ෌⏕⏕≀ᐇ㦂ࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࢆி㒔኱Ꮫ࡜ྜྠ࡛㛤ദࡋࠊࡲࡓࠊ⏕≀⏬ീゎᯒࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࢆ᪂ศ㔝๰ᡂࢭࣥࢱ࣮࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫ◊✲ศ㔝࡜ྜྠ࡛㛤ദࡋࡓࠋࡇࡢᵝ࡞άືࢆ㏻ࡌ࡚
◊✲⪅࡬ࡢ᭱᪂㢧ᚤ㙾ᢏ⾡࡜ゎᯒᡭἲࡢᬑཬ࡟㈉⊩ࡋࡓࠋ㸱㸧ගࢩ࣮ࢺᆺ㢧ᚤ㙾㸦'6/0㸧ඹྠ฼⏝ᐇ㦂㈨ᩱ㹎 ࣓ࢲ࢝㏱᫂໬⬻඲యࠊࢮࣈࣛࣇ࢕ࢵࢩࣗ⾑⟶⣔࠾ࡼࡧ᳝㦵ࠊ࢔࣓࣮ࣂ㸦Amoeba
proteus㸧㐠ືࠊ㨶㢮⾲⓶⣽⬊㐟㉮࡞࡝ࠊࡇࡢ㢧ᚤ㙾ࡢ῝㒊ほᐹ⬟࡜㧗㏿ほᐹ⬟ࢆ⏕࠿ࡋࡓඹྠ฼⏝◊✲ࢆ㸷௳ᐇ᪋ࡋࡓࠋࡇࢀࡽ࡜ࡣู࡟ࠊEMBL࡜ࡢඹྠ◊✲࡜ࡢᡂᯝ࡜ࡋ࡚࣐࢘ࢫ⬇ࡢࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢἲࢆㄽᩥⓎ⾲ࡋࡓࠋࡲࡓࠊ᪂ࡋ࠸ග※࡛࠶ࡿࣇ࢓࢖ࣂ࣮࣮ࣞࢨ࣮ࢆ⏝࠸ࡿࡇ࡜࡛௒ࡲ࡛࡟࡞࠸ᗈど㔝ࢆ㐩ᡂࡋࡓ㸰ගᏊ
DSLMࢆ㛤Ⓨࡋࠊ࣓ࢲ࢝⛶㨶ෆ㒊ࡢࡼࡾ㩭᫂࡞ࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢ࡟ᡂຌࡋࡓࠋ
㸲㸧࣓ࢲ࢝ࣂ࢖࢜ࣜࢯ࣮ࢫ㈨ᩱ㹎 ➨㸱ᮇࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫࣉࣟࢪ࢙ࢡࢺ㸦NBRP㸧࡛ࡣࣜࢯ࣮ࢫࡢ㉁ࡢ☜ಖࢆᅗࡿࡓࡵ㏆஺⣔ࠊཎᅉ㑇ఏᏊࡢุ᫂ࡋ࡚࠸ࡿ✺↛ኚ␗యࠊ㑇ఏᏊᑟධ⣔⤫࡟㛵ࡋ࡚ࡣ㑇ఏⓗࣔࢽࢱࣜࣥࢢࢆᐇ᪋ࡋࠊ㉁ࡢ☜ಖࡉࢀࡓ࣓ࢲ࢝ࣂ࢖࢜ࣜࢯ࣮ࢫࢆ
ࡼࡾᏳᐃⓗ࡟ᥦ౪ࡍࡿయไࢆᵓ⠏ࡋࡓࠋࡲࡓ㏫㑇ఏᏛⓗᡭἲ࡟ࡼࡿ◊✲ࢆ᥎㐍ࡍࡿࡓࡵHigh resolution melting㸦HRM㸧ἲ࡟ࡼࡿኚ␗యࢫࢡ࣮ࣜࢽࣥࢢࢩࢫࢸ࣒ࡢᥦ

−8−౪ࢆ⥅⥆ࡋ࡚࠸ࡿࠋᖹᡂᖺᗘࡢ࣓ࢲ࢝ࣛ࢖ࣈࣜࢯ࣮ࢫࡢ཰㞟⣔⤫ᩘࡣ⣔⤫ࠊᥦ౪⣔⤫ᩘࡣ⣔⤫࡛࠶ࡗࡓࠋcDNA/BAC/Fosmidࡢᥦ౪࡛ࡣࢡ࣮࡛ࣟࣥ࠶ࡗ
ࡓࠋᏤ໬㓝⣲ࡣᮏࢆᥦ౪ࡋࡓࠋࡲࡓ᪂ࡓ࡟࣓ࢲ࢝㏆⦕✀%$&ࢡ࣮ࣟࣥࡢ3D-PCR࡟ࡼࡿࢫࢡ࣮ࣜࢽࣥࢢ⣔ࢆᵓ⠏ࡋ㏆⦕✀BACࢡ࣮ࣟࣥࡢᥦ౪ࡶ㛤ጞࡋࡓࠋࡉࡽ࡟
PacBioRSIIࢩ࣮ࢡ࢚ࣥࢧ࣮࡟ࡼࡾ㏆஺⣔Hd-rRIIࢆᮦᩱ࡜ࡋ࡚ࢤࣀ࣒ಸ┦ᙜࡢࢤࣀ࣒ሷᇶ㓄ิỴᐃࡶ⾜ࡗࡓࠋᅜෆࢩ࣏ࣥࢪ࣒࢘ࠕᵝࠎ࡞ື≀ࢆࡶࡕ࠸ࡓࣄࢺ⑌ᝈ࣭
⑓ែࣔࢹࣝゎᯒ࡬ࡢ࢔ࣉ࣮ࣟࢳࠖ
㸦➨ᅇ᪥ᮏື≀Ꮫ఍ࢩ࣏ࣥࢪ࣒࢘㸧ࢆඹദࡋࡓࠋ
ࡲࡓᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࠕThe 4th International Symposium of Oryzias Fish “ Biodiversity
and Environmental Science of Marine and Fresh Water Fishes”㸦University of Hasanuddin,
Makassar㺂Indonesia ᖺ᭶᪥㸧ࠖࢆඹദࡋࡓࠋ
㸳㸧࢔ࢧ࢞࢜ࣂ࢖࢜ࣜࢯ࣮ࢫ㈨ᩱ㹎 ➨㸱ᮇNBRP㸦++ᖺᗘ㸧࡟࠾࠸࡚ࠊ࠾ࡼࡑࡢ࢔ࢧ࢞࢜ࡢBACࢡ࣮ࣟࣥࢆ཰㞟ࡋࠊ௨ୖࡢྛ✀DNAࢡ࣮ࣟࣥࢆᅜෆእࡢ◊✲⪅࡟ᥦ౪ࡍࡿ࡞࡝ࡋࡓࠋ
ࡲࡓࠊ᳜≀⛉Ꮫ᭱ඛ➃ᣐⅬࢿࢵࢺ࣮࣡ࢡ࡛ᑟධࡉࢀࡓ᳜≀⎔ቃไᚚࢩࢫࢸ࣒࡛࢔
ࢧ࢞࢜ࢆ᱂ᇵࡋࠊࡑࡢࣛ࢖ࣈ࢖࣓࣮ࢪࢆᡤእࡢඹྠ◊✲⪅࡟ᥦ౪ࡍࡿࡇ࡜࡛ࠊ᪂つ✺↛ኚ␗యࡢࢫࢡ࣮ࣜࢽࣥࢢࡶ⾜ࡗࡓࠋ㸴㸧᳜≀⛉Ꮫ᭱ඛ➃◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡ㈨ᩱ 㹎 ࢿࢵࢺ࣮࣡ࢡࡢ୍ᣐⅬ࡜ࡋ࡚ࠊ ᖺᗘ࡟ᑟධࡋࡓ⏬ീࢹ࣮ࢱ㓄ಙᆺࡢ᳜≀⎔ቃไᚚࢩࢫࢸ࣒ࠊ⸴㢮ࡢගྜᡂᶵ⬟ゎᯒ⿦⨨ࠊḟୡ௦ DNA ࢩ࣮ࢡ࢚ࣥࢧ࣮ࡢඹྠ฼
⏝◊✲ࢆᘬࡁ⥆ࡁ⾜ࡗࡓࠋ฼⏝⪅ࡣ᪥ᮏᅜෆࡔࡅ࡛࡞ࡃࣇࣛࣥࢫ࣭ࢫ࢖ࢫᅾఫࡢ
◊✲⪅ࡶ࠾ࡾࠊ༢ᖺᗘࡢࡳࡢ⏦ㄳࡔࡅ࡛࡞ࡃࠊ⥅⥆ࡋࡓ฼⏝ࡀከࡃ⾜ࢃࢀ࡚࠸ࡿࠋ
ḟୡ௦ DNA ࢩ࣮ࢡ࢚ࣥࢧ࣮ࡣࠊIllumina HiSeq2000 ࢆ HiSeq2500 ࡟࢔ࢵࣉࢢ࣮ࣞ
ࢻࡋࢩ࣮ࢡ࢚ࣥࢫ⬟ຊࢆ㧗ࡵࠊ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࡢ኱㔞࠿ࡘከᵝ࡞ࢽ࣮ࢬ࡟
ᛂ࠼ࡿᇶ┙ࢆᩚ࠼ࡓࠋᖹᡂ  ᖺᗘࡣ᳜≀⎔ቃไᚚࢩࢫࢸ࣒㸲௳ࠊගྜᡂᶵ⬟ゎᯒ⿦⨨㸯௳ࠊḟୡ௦ DNA ࢩ࣮ࢡ࢚ࣥࢧ࣮ᨭ᥼ࡣࡇࢀࡲ࡛ࡢ  ㄢ㢟࡟ຍ࠼࡚ࠊ᪂つ࡟㸷ㄢ㢟ࢆཷධࢀࡓࠋึᖺᗘ࡟㛤ጞࡋࡓ◊✲ࡣࠊㄽᩥⓎ⾲࡟ࡘ࡞ࡀࡿᡂᯝࡀฟ࡚
ࡁ࡚࠸ࡿࠋ
㸵㸧኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦,%%3㸧㈨ᩱ 㹎 ᖹᡂ  ᖺ  ᭶  ᪥࡟Ⓨ⏕ࡋࡓᮾ᪥ᮏ኱㟈⅏࡛ࡣᮾ໭ᆅ᪉ࢆ୰ᚰ࡟ከࡃࡢ኱Ꮫ࣭
◊✲ᡤࡀ⿕⅏ࡋࡓࠋ㟈⅏࡟ࡼࡿ┤᥋ⓗ࡞⿕ᐖ࡜࡜ࡶ࡟㛗ᮇ㛫ࡢ೵㟁࡟ࡼࡗ࡚ࠊᜏ
ᐊࡸࣇ࣮ࣜࢨ࣮ࡢ⥔ᣢࡀ୙ྍ⬟࡟࡞ࡾࠊᐇ㦂◊✲࡟⏝࠸ࡿኚ␗యࡸ㑇ఏᏊᑟධ−9−ಶయ࡞࡝㛗ᖺࡢດຊ࡟ࡼࡗ࡚సᡂࡋ࡚ࡁࡓ㈗㔜࡞⣔⤫ࠊcDNAࢤࣀ࣒ࢡ࣮ࣟࣥࡢ
ࡼ࠺࡞◊✲࡟࡞ࡃ࡚ࡣ࡞ࡽ࡞࠸ᐇ㦂ᮦᩱ࡞࡝ከࡃࡢ⏕≀㑇ఏ㈨※ࡀኻࢃࢀࡓࠋࡑ
ࡢ⤖ᯝࠊከࡃࡢ◊✲⪅ࡀ◊✲ࡢ㐜⁫ࡸ◊✲᪉ྥࡢ㌿᥮ࢆవ൤࡞ࡃࡉࢀࡓࠋつᶍࡢ㐪࠸ࡣ࠶ࢀࠊࡑࡢࡼ࠺࡞⅏ᐖࡣ௒ᚋࡶ࠾ࡇࡿྍ⬟ᛶࡀ࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋࡇࡢࡼ
࠺࡞஦ែࢆᮍ↛࡟㜵ࡄࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ᅜෆࡢ㸵኱Ꮫ㸦໭ᾏ㐨኱Ꮫࠊᮾ໭኱Ꮫࠊ
ᮾி኱Ꮫࠊྡྂᒇ኱Ꮫࠊி㒔኱Ꮫࠊ኱㜰኱Ꮫࠊ஑ᕞ኱Ꮫ㸧࡜༠ᐃࢆ⤖ࡧ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦IBBP㸧ࢆ㛤ጞࡋࡓࠋࡇࡢࣉࣟࢪ࢙ࢡࢺ࡛ࡣ୰
᰾ⓗࣂࢵࢡ࢔ࢵࣉಖ⟶᪋タ࡜ࡋ࡚ IBBP ࢭࣥࢱ࣮ࢆᇶ♏⏕≀Ꮫ◊✲ᡤ࡟タ⨨ࡍࡿ࡜࡜ࡶ࡟㸵኱Ꮫ࡟኱Ꮫࢧࢸࣛ࢖ࢺᣐⅬࢆ⨨ࡁ඲ᅜࢆ࢝ࣂ࣮ࡍࡿ⏕≀㑇ఏ㈨※ࡢࣂࢵࢡ࢔ࢵࣉయไࢆᩚഛࡋࡓࠋᖹᡂ  ᖺᗘ࡟ࡣ  ௳ࡢࣂࢵࢡ࢔ࢵࣉಖ⟶⏦ㄳࢆ᥇ᢥࡋࡓࠋ⌧ᅾࡢಖ⟶㔞ࡣ  ✰ࣉ࣮ࣞࢺ࡟ࡼࡿಖ⟶࡛ࡣ  ᯛ㸦 ࢧࣥࣉࣝ㸧ࠊࢳ࣮ࣗࣈ࡟ࡼࡿಖ⟶࡛ࡣ  ᮏ㸦 ࢧࣥࣉࣝ㸧࡟ཬࢇ࡛࠸ࡿࠋࡼࡾከ
ᵝ࡞⏕≀㑇ఏ㈨※ࢆࣂࢵࢡ࢔ࢵࣉಖ⟶࡛ࡁࡿయไࢆᶞ❧ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚ࠊᖹᡂ  ᖺᗘ࠿ࡽ㛤ጞࡋࡓ⏕≀㑇ఏ㈨※᪂つಖᏑᢏ⾡㛤Ⓨඹྠ฼⏝◊✲࡛ࡣࠊ ௳ࡢබເࡀ࠶ࡗࡓࠋIBBP ィ⏬᥎㐍ጤဨ఍࡛ᑂ㆟ࢆ⾜ࡗࡓ⤖ᯝࠊ㸷௳ࡢඹྠ฼⏝◊✲ࢆ᥇ᢥࡋࡓࠋ㈨ᩱ 㹎ࠋ− 10 −

,,,ᅜ㝿㐃ᦠ࡜ᗈሗάືࡢᒎ㛤,,,Dᅜ㝿㐃ᦠ㈨ᩱ 㹎
㸯㸧1,%%&RQIHUHQFH ࡢ㛤ദ ᖺ  ᭶  ᪥ࠊᒸᓮࢥࣥࣇ࢙ࣞࣥࢫࢭࣥࢱ࣮࡟࠾࠸࡚ࠊ➨  ᅇ NIBB ࢥ
ࣥࣇ࢓ࣞࣥࢫ͆Cellular Community in Mammalian Embryogenesis͇ࢆ㛤ദࡋࡓࠋᅜෆ
௨እ࡟࢖ࢠࣜࢫࠊࢫ࣌࢖ࣥࠊ࢝ࢼࢲࠊ୰ᅜࠊࢩ࣏࣮ࣥ࢞ࣝࠊࢫ࢖ࢫ࠿ࡽࡢᣍ⪸ㅮ
₇⪅ࢆ㏄࠼ࠊ୍⯡ཧຍ⪅ࢆྵࡵࡿ࡜  ྡᙅࡢཧຍ⪅ࡀ㞟࠸ࠊᏊᐑෆ࡜࠸࠺≉Ṧ࡞⎔ቃୗ࡛㐍⾜ࡍࡿࠕ့ங㢮ึᮇⓎ⏕ࠖ࡜࠸࠺㠀ᖖ࡟ࣇ࢛࣮࢝ࢫࡉࢀࡓㄢ㢟࡟ࡘ࠸࡚ࠊ᪥㐍᭶Ṍ࡜ゝ࠼ࡿᙜヱศ㔝ࡢ᭱᪂ࡢ▱ぢ࡜௒ᚋࡢ◊✲ࡢ᪉ྥ࡟ࡘ࠸࡚㆟ㄽࡋࡓࠋ࣐࢘ࢫࢆ୰ᚰ࡜ࡍࡿ့ங㢮ึᮇ⬇Ⓨ⏕࡟࠾࠸࡚ࡣࠊ᪥ᮏᅜෆࡢ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࡀୡ⏺ࢆ࣮ࣜࢻࡍࡿࡶࡢࡀከࡃ࠶ࡾࠊᅜእཧຍ⪅࡟࢖ࣥࣃࢡࢺࢆ୚࠼
ࡓࠋ࣐࢘ࢫ⬇௨እࡢ့ங㢮ึᮇ⬇࡟㛵ࡍࡿ◊✲ࡸࠊ╔ᗋᚋ⬇ࠊ⬇Ⓨ⏕࡟㛵㐃ࡍࡿᩘ⌮Ꮫⓗ࡞◊✲࡞࡝࡟ࡘ࠸࡚ࡢⓎ⾲ࡀ࠶ࡾࠊዟ⾜ࡁ࡜ᗈࡀࡾࢆ୚࠼ࡓࠋࡇࢀࡔࡅ
ࣇ࢛࣮࢝ࢫࡉࢀࡓㄢ㢟࡟ࡘ࠸࡚ࠊඛ➃ࡢ◊✲⪅ࡀ㞟ࡲࡗ࡚㆟ㄽࡍࡿᶵ఍ࡣࠊୡ⏺
ⓗ࡟௚࡟㢮ࢆࡳ࡞࠸ᕼ᭷࡞ᶵ఍࡛༳㇟ⓗ࡞ࡶࡢ࡜࡞ࡗࡓࠋ㏆࠸⯆࿡ࢆᣢࡘ◊✲⪅ࡀୡ⏺୰࠿ࡽ㞟ࡲࡾࠊ࣏ࢫࢱ࣮ࢭࢵࢩࣙࣥࡸ࢚ࢡࢫ࣮࢝ࢩࣙࣥࠊ᠓ぶ఍ࡢ᫬㛫࡞࡝ࡶ౑ࡗ࡚◊✲ࡢ୰࡛ࡢㄢ㢟ࡸ◊✲ࡢᑗ᮶ീࡲ࡛ࡌࡗࡃࡾ࡜㆟ㄽࡍࡿࡇ࡜ࡀ࡛ࡁࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫࡢព⩏ࡀ෌☜ㄆࡉࢀࡓࠋ࡞࠾ࠊ௒ᅇࡢ NIBB ࢥࣥࣇ࢓ࣞࣥࢫ
ࡣ⛉Ꮫ◊✲㈝⿵ຓ㔠࣭᪂Ꮫ⾡㡿ᇦ◊✲ࠕ့ங㢮ึᮇⓎ⏕ࡢ⣽⬊ࢥ࣑ࣗࢽࢸ࢕࣮ࠖ
࡜ࡢඹദ࡛࠶ࡾࠊඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ᅜෆࡢ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࡢⓎᒎ࡟㈉⊩ࡋ࡚࠸ࡿࠋ㸰㸧ḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸦(0%/㸧࡜ࡢᅜ㝿ඹྠ◊✲ ᖺ  ᭶  ᪥㹼 ᪥࡟ EMBL Heidelberg㸦⊂ᅜ㸧࡟࠾࠸࡚⾜ࢃࢀࡓ EMBL
PhD Ꮫ⏕୺ᐓࡢࢩ࣏ࣥࢪ࣒࢘ The 15th EMBL PhD Symposium “Competition in
Biology: The Race for Survival, from Molecules to Systems” ࡟㸱ྡࡢ኱Ꮫ㝔⏕㸦༤ኈㄢ⛬㸧ࢆὴ㐵ࡋࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ᒎ㛤ࡋ࡚࠸ࡿ᭱᪂ࡢ◊✲ᡂᯝࡢⓎ⾲ཬࡧ㆟ㄽࢆ⾜ࡗࡓࠋ᭦࡟ࢩ࣏ࣥࢪ࣒࢘࡟๓ᚋࡋ࡚ࠊ㛵㐃◊✲ศ㔝ࡢ EMBL Heidelberg ࢟ࣕࣥࣃࢫ࠾ࡼࡧࠊMonterotondo ࢔࢘ࢺࢫࢸ࣮ࢩࣙࣥ㸦ఀᅜ㸧ࡢ◊✲ᐊ࡟⁫ᅾࡋ࡚◊✲ᡂᯝ࡟ࡘ࠸࡚ࡢㅮ₇࡜࡜ࡶ࡟ࠊヲ⣽࡞◊✲ᡂᯝࡢ஺᥮ࢆ⾜ࡗࡓࠋ ᖺ  ᭶࡟ࡣ
EMBL Heidelberg ࡟ᩍဨ㸦෸ᩍᤵ㸧㸯ྡࢆὴ㐵ࡋࠊᇶ♏⏕≀Ꮫ◊✲ᡤගᏛゎᯒᐊ࡞࡝࡛⾜ࢃࢀ࡚࠸ࡿ᳜≀⣽⬊ࡢ㧗ゎീᗘࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢࡢࢹ࣮ࢱ࡜ࠊEMBL ࡟࠾࠸࡚㛤Ⓨࡀ㐍ࢇ࡛࠸ࡿ࢖࣓࣮ࢪࣥࢢࠊ⏬ീゎᯒ࡜ࢥࣥࣆ࣮ࣗࢱࢩ࣑࣮ࣗࣞࢩࣙ

− 11 −

ࣥ◊✲࡟㛵ࡋ࡚ࠊ཮᪉ࡢ᭱᪂ࡢ◊✲ᡂᯝࢆ஺᥮ࡋࡓࠋ᭦࡟ࠊEMBL ࡀ୺ᐓࡍࡿࢩ
࣏ࣥࢪ࣒࢘㸦 ᖺ  ᭶ࠊ ᖺ  ᭶㸧࡟ᩍဨ㸦ᩍᤵࠊຓᩍ㸧ࠊ࣏ࢫࢺࢻࢡཬࡧ
኱Ꮫ㝔⏕ィ㸳ྡࢆὴ㐵ࡋࠊ⏕యෆ⎔ቃࡢసࡿࣔࣝࣇ࢛ࢤࣥ໙㓄ࡸࠊ⏕యእ⎔ቃ࡟㢧ⴭ࡞ᛂ⟅ࢆ♧ࡍ࣑ࢪࣥࢥࢆ⏝࠸ࡓ◊✲࡟ࡘ࠸࡚ࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࡟࠾ࡅࡿ◊✲ࡢᡂᯝࢆᥦ౪ࠊ᭱๓⥺ࡢ᝟ሗࢆ཰㞟ࡍࡿ࡜࡜ࡶ࡟ EMBL ࠾ࡼࡧḢᕞࢆࡣࡌࡵ࡜
ࡍࡿ◊✲⪅࡜௒ᚋࡢ◊✲࡟ྥࡅ࡚ࡢ㆟ㄽࢆ⾜ࡗࡓࠋࡲࡓࠊᩍဨ㸯ྡ㸦ᩍᤵ㸧ࡀ EMBL
Monterotondo ࢔࢘ࢺࢫࢸ࣮ࢩ࡛࣐ࣙࣥ࢘ࢫ⢭Ꮚᖿ⣽⬊◊✲࡟ࡘ࠸࡚ࡢᣍᚅㅮ₇ࢆ
⾜࠸ࠊᑗ᮶ࡢඹྠ◊✲࡟ࡘ࠸࡚ࡢ㆟ㄽࢆ⾜ࡗࡓࠋࡇࡢࡼ࠺࡟ࠊ」ᩘࡢࢳࣕࣥࢿࣝ
࡛ࡢ◊✲஺ὶࢆ⾜ࡗࡓࠋ ࡲࡓࠊEMBL ࠿ࡽᇶ♏⏕≀Ꮫ◊✲ᡤ࡟ᢏ⾡⛣㌿ࡋࡓึᮇᆺḟୡ௦㢧ᚤ㙾ගࢩ࣮ࢺ㢧ᚤ㙾㸦DSLM㸧ࡢ᭱㐺໬ࢆ㐍ࡵࠊ࡜ࡃ࡟⏕ࡁࡓ࣐࢘ࢫ⬇࡟࠾ࡅࡿ⣽⬊⛣ືࡢほᐹ⣔ཬࡧ⣽⬊㏣㊧ࣉࣟࢢ࣒ࣛࡢ㛤Ⓨࢆ⾜ࡗࡓࠋࡇࡢᡭἲࡢヲ⣽࡜ᚓࡽࢀࡓⓎ⏕Ꮫ▱ ぢ ࢆ ࠊ EMBL ࡜ ࡢ ᅜ 㝿 㐃 ᦠ࡟ ࡼ ࡿඹ ྠ◊ ✲ ࡢ ᡂᯝ ࡜ ࡋ࡚ ㄽᩥ ࡟ බ ⾲ࡋ ࡓ
㸦Ichikawa et al. PLoS One 2013, Nature Protocols 2014㸧ࠋࡲࡓྠ㢧ᚤ㙾ࢆ⏝࠸ࡓඹྠ฼⏝◊✲ࡣ㸷௳⾜ࢃࢀࡓࠋ㸱㸧ࢸ࣐ࢭࢡ⏕࿨⛉Ꮫ◊✲ᡤ㸦7//㸧ཬࡧ࣐ࢵࢡࢫࣉࣛࣥࢡ᳜≀⫱✀Ꮫ◊✲ᡤ
03,3= ࡜ࡢᅜ㝿ඹྠ◊✲ ᖹᡂ  ᖺ  ᭶࡟㛤ദࡋࡓᇶ♏⏕≀Ꮫ◊✲ᡤࠊ࣐ࢵࢡࢫࣉࣛࣥࢡ᳜≀⫱✀Ꮫ◊✲ᡤ 㸦MPIPZ㸧ࠊࢸ࣐ࢭࢡ⏕࿨⛉Ꮫ◊✲ᡤ 㸦TLL㸧ࡢ㸱ᶵ㛵ྜྠࡢࢩ࣏ࣥࢪ࣒࢘ࠊ
The 4th NIBB-MPIPZ-TLL Joint Symposium͆Arabidopsis and Emerging Model Systems͇࡟⥆ࡃ➨㸳ᅇࢩ࣏ࣥࢪ࣒࢘ࢆ᮶ᖺᗘ㛤ദࡍࡿ‽ഛ㆟ㄽࢆ⾜ࡗࡓࠋ ᖺ࡟ MPIPZ
࡟ᩍဨ㸦ຓᩍ㸧ࢆὴ㐵ࡋ࡚ඹྠᐇ㦂ࢆ⾜ࡗࡓ᳜≀࢜ࣝ࢞ࢿࣛࡢᶵ⬟࡟㛵ࡍࡿඹྠ◊✲ࢆ᥎㐍ࡋࠊㄽᩥࢆᏛ⾡㞧ㄅ㸦Frontiers in Plant Science㸧࡟ᇳ➹ࡋࡓࠋ่⬊ື≀
ࡢⓎ⏕࡟㛵ࡍࡿ TLL ࡜ࡢᅜ㝿ඹྠ◊✲ࡢᡂᯝࢆᏛ⾡㞧ㄅ㸦Developmental Biology㸧࡟ᇳ➹ࡋࡓࠋ
㸲㸧࣎ࢺ࣒࢔ࢵࣉᆺᅜ㝿㐃ᦠࡢ❧ࡕୖࡆ ᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ࡣࠊ ᖺ௨ୖ࡟ࢃࡓࡾᶵ㛵㛫㐃ᦠ࡟ᇶ࡙ࡃඹྠ◊✲ࢆ᥎㐍ࡋࠊᅜ㝿Ꮫ⾡ᣐⅬ࡜ࡋ࡚ᇶ♏⏕≀Ꮫࢆ≌ᘬࡍࡿດຊࢆ✚ࡳ㔜ࡡ࡚ࡁࡓࠋᖺ᮶ࡢᶵ
㛵㛫㐃ᦠ࡟ᇶ࡙ࡃࢩ࣏ࣥࢪ࣒࢘ࡸὴ㐵஦ᴗ࡞࡝ࡢᡂᯝ࡜ࡋ࡚ࠊ◊✲ᡤෆ࠾ࡼࡧᅜ
ෆࢥ࣑ࣗࢽࢸ࢕࣮ࡢᅜ㝿ඹྠ◊✲࡬ࡢᣦྥࡸᚲせᛶ࡟ࡘ࠸࡚ࡢព㆑ࡀ㧗ࡲࡗࡓࠋࡑࡢ⤖ᯝࠊ⌧ᅾࡣᚲࡎࡋࡶᶵ㛵㛫㐃ᦠ࡟㢗ࡽ࡞࠸ᙧ࡛ࡢඹྠ◊✲ࢆᶍ⣴ࡋࡓࡾࠊࡍ࡛࡟ඹྠ◊✲࡜ࡋ࡚❧ࡕୖࡀࡾᡂᯝࢆᣲࡆ࡚࠸ࡿࡶࡢࡶᑡ࡞ࡃ࡞࠸ࠋ

− 12 − ࡇࡢ⌧≧ࢆ㚷ࡳࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢᅜ㝿㐃ᦠࡢḟࡢᒎ㛤ࡢ᳨ウࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊಶࠎࡢ◊✲ᐊ࡛ࣞ࣋ࣝࡢᅜ㝿ඹྠ◊✲ࢆᙉࡃ᥎㐍ࡍࡿ࡜࡜ࡶ࡟ࠊࡑࢀࢆ
ࢥ࢔࡜ࡋ࡚ᅜෆࡢ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࢆ⧅ࡄᮏ᱁ⓗ࡞ᅜ㝿㐃ᦠάື࡟Ⓨᒎࡉࡏ࡚⾜ࡃࡇ࡜ࢆ┠ⓗ࡟ࠕ࣎ࢺ࣒࢔ࢵࣉᆺࠖᅜ㝿㐃ᦠࡢࢩࢫࢸ࣒ࢆ❧ࡕୖࡆࡓࠋ ᖺᗘึࡵࡼࡾࢫࢱ࣮ࢺࡍࡿ࡭ࡃࠊᡤෆබເࢆ⾜ࡗࡓࠋ,,,Eᗈሗ࣭࢔࢘ࢺ࣮ࣜࢳάື
㸯㸧ᇶ♏⏕≀Ꮫ◊✲ᡤ࣮࣒࣮࣍࣌ࢪࡸ 616 ࢆ⏝࠸ࡓᗈሗάື
◊✲⪅ྥࡅࡢᇶ♏⏕≀Ꮫ◊✲ᡤ࣮࣒࣮࣍࣌ࢪ㸦KWWSZZZQLEEDFMS㸧ࡢ௚ࠊ୍ ⯡ ࡟ ྥ ࡅ ࡓ ᝟ ሗ Ⓨ ಙ ࢧ ࢖ ࢺ ࠕ ᇶ ♏ ⏕ ≀ Ꮫ ◊ ✲ ᡤ WEB ࣐ ࢞ ࢪ ࣥ
㸦KWWSZZZQLEEDFMSZHEPDJ㸧ࠖ࡟࠾࠸࡚࢔࢘ࢺ࣮ࣜࢳࡸᏛᰯᩍ⫱ྥࡅࡢࢥࣥࢸࣥࢶࡢ඘ᐇࢆᅗࡗࡓࠋࡲࡓࠊ኱Ꮫ⏕࣭኱Ꮫ㝔⏕ࢆ୺࡞ࢱ࣮ࢤࢵࢺ࡜ࡋ࡚ᇶ♏
⏕≀Ꮫ◊✲ᡤ facebook ࣮࣌ࢪ㸦KWWSZZZIDFHERRNFRPQLEEMSQ㸧࠾ࡼࡧᗈሗ
ᐊ Twitter ࢔࢝࢘ࣥࢺ㸦#QLEEBSXEOLF㸧ࢆ⏝࠸ࡓ᝟ሗⓎಙࢆ⾜ࡗࡓࠋ㸰㸧◊✲ᡤ୍⯡බ㛤ࢆ㛤ദ ᭶  ᪥㸦ᅵ㸧࡟ᇶ♏⏕≀Ꮫ◊✲ᡤ୍⯡බ㛤ࠕయឤ㸟᭱ඛ➃ࣂ࢖࢜ࡢୡ⏺ࠖࢆ㛤ദࡋࡓࠋᒣᡭᆅ༊ࡢࣛ࣎ࡢබ㛤ࡢ௚ࠊࣈ࣮ࢫᒎ♧࡞࡝࡛ࠊྛ◊✲ᐊ࡛⾜ࢃࢀ࡚࠸ࡿ◊✲άື࡟ࡘ࠸࡚ゎㄝࡍࡿ࡜ඹ࡟ࠊㅮ₇఍ࠊࢧ࢖࢚ࣥࢫࢺ࣮ࢡࠊయ㦂ᐇ㦂ࠊࢡ࢖ࢬࢫࢱࣥࣉ࣮ࣛࣜࠊ⏕ࡁ≀ࢡࣛࣇࢺ࢔࣮ࢺࡢᒎ♧࡞࡝ࠊᏊ౪࠿ࡽ኱ேࡲ࡛ࡀ
ᴦࡋࡵࡿࡼ࠺࡟ᵝࠎ࡞௻⏬ࢆᐇ᪋ࡋࡓࠋ᮶ሙ⪅ࡣ  ྡ࡛࠶ࡗࡓࠋ
㸱㸧ࣉࣞࢫ࣮ࣜࣜࢫ࡟ࡼࡿ◊✲ᡂᯝⓎಙᖹᡂ  ᖺᗘࡣࠊ ௳ࡢ◊✲ᡂᯝሗ࿌ࢆࣉࣞࢫ࣮ࣜࣜࢫ࡜ࡋ࡚ሗ㐨ᶵ㛵࡟ྥࡅ࡚Ⓨಙࡋࡓࠋ
㸲㸧༳ๅ≀ࡢⓎ⾜ ᇶ♏⏕≀Ꮫ◊✲ᡤせぴ  ࠾ࡼࡧ Annual Report 2012 ࢆⓎ⾜ࡋࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤࣃࣥࣇࣞࢵࢺ᪥ᮏㄒ∧࠾ࡼࡧⱥㄒ∧ࢆⓎ⾜ࡋࡓࠋࡲࡓ᪂ࡓ࡟㸴࣮࣌ࢪ࠿ࡽ
࡞ࡿᗈሗㄅࠕᇶ♏⏕≀Ꮫ◊✲ᡤ࣐࢞ࢪࣥࠖࢆห⾜ࡋࡓࠋ㸳㸧⌮⛉ᩍ⫱࡬ࡢ༠ຊ ឡ▱┴ෆࡢ SSH ᣦᐃᰯࡢ⏕ᚐࢆᑐ㇟࡜ࡋࡓయ㦂ᐇ⩦ࠕ᪂ㄢ⛬ᩍ⫱ࡢᇶ♏࡜࡞ࡿ᳜≀ࡢ᭱ඛ➃◊✲ࠖ㸦㛗㇂㒊ගὈᩍᤵ࠾ࡼࡧ⏕≀㐍໬◊✲㒊㛛ࡢ࣓ࣥࣂ࣮ࡀᑐᛂ㸧− 13 −

ࢆ㛤ദࡋࡓࠋឡ▱┴❧ᒸᓮ㧗ᰯࡢ SSH άື࡬ࡢ༠ຊ࡜ࡋ࡚ࠊ㸰ྡࡢᩍᤵࡀฟ๓ᤵ
ᴗࢆᐇ᪋ࡋࡓࠋࡲࡓࠊឡ▱┴ࡢ㧗ᰯ⏕ࡽ࡟ࡼࡿ◊✲Ⓨ⾲࢖࣋ࣥࢺࠕ⛉Ꮫ୕᫕ LQ ࠶࠸ࡕࠖ࡟࠾࠸࡚ࠊ◊✲⤂௓ࣈ࣮ࢫᒎ♧ࢆ⾜࠺࡜ඹ࡟ࠊⱥㄒ࡛ࡢ◊✲Ⓨ⾲ࡢᣦᑟࢆ⾜ࡗࡓࠋᒸᓮᕷᩍ⫱ጤဨ఍࠿ࡽࡢせㄳ࡟ࡼࡾࠊⱝᡭᩍဨ࡟ࡼࡿᕷෆ㸵࢝ᡤࡢ୰Ꮫ
ᰯ࡛ࡢฟ๓ᤵᴗ࠾ࡼࡧࠊᑠ୰Ꮫᰯ⌮⛉ᩍㅍྥࡅࡢࠕᅜ◊ࢭ࣑ࢼ࣮ࠖ㸯௳ࢆᐇ᪋ࡋ
ࡓࠋࡲࡓࠊᒸᓮᕷࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࢫࢡ࣮ࣝ஦ᴗ㸦ᑠ୰Ꮫᰯᑐ㇟㸧ࡢ୍⎔࡜ࡋ࡚ࠊ㸱௳ࡢฟ๓ᐇ⩦ࢆ⾜ࡗࡓࠋࡑࡢ௚ࠊᒸᓮᕷෆࡢᑠᏛᰯ㸯௳ࠊ࠾ࡼࡧᖾ⏣⏫ࡢ୰Ꮫᰯ࡟࠾࠸࡚ฟ๓ᤵᴗ㸯௳ࢆ⾜ࡗࡓࠋ୍⯡ྥࡅࢧ࢖࢚ࣥࢫࢺ࣮ࢡࠕࢤࣀ࣒ࡢࢦ
࣑࡜ᛮࢃࢀ࡚࠸ࡓࡶࡢ㹼࢖ࢿࡢືࡃ㑇ఏᏊ㹼ࠖࢆྡྂᒇ኱Ꮫ࡜ඹ࡟㛤ദࡋࡓࠋ୰
Ꮫ⏕ྥࡅࡢኟఇࡳయ㦂ᐇ⩦ࠕࣄࢻࣛࡢయࢆᵓᡂࡍࡿ⣽⬊ࡢ✀㢮ࢆぢศࡅࡼ࠺ࠖࢆ
㛤ദࡋࡓࠋ
㸴㸧኱Ꮫ⏕ྥࡅࡢᗈሗ࢖࣋ࣥࢺ ࠕ኱Ꮫ⏕ࡢࡓࡵࡢኟࡢᐇ⩦ࠖࢆ㛤ദࡋࠊ ྡࡢᏛ㒊Ꮫ⏕ࡀཧຍࡋࡓࠋ
− 14 −

,9᪂㡿ᇦࡢ㛤ᣅ,9D⎔ቃ㐺ᛂᡓ␎㈨ᩱ 㹎 ᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ࡣࠊ⏕≀ࡢᇶᮏⓗ࡞㑇ఏᏊࡢാࡁࡸ⣽⬊ࡢാࡁࢆ᥈ࡿࡇ࡜
ཬࡧࠊ⏕Ꮡ⎔ቃ࡟㐺ᛂࡋࡓ⏕≀ࡀከᵝ࡞ᙧ࡜⬟ຊࢆᣢࡘ࡟⮳ࡗࡓ௙⤌ࡳࢆㄪ࡭ࡿ
ࡇ࡜ࢆ᭱ࡶ㔜せ࡞◊✲┠ᶆ࡜ࡋ࡚࠸ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ࡛ࡣࠊ⏕≀ࡢ⎔ቃᛂ⟅ᶵᵓࢆࢤࣀ࣒⛉Ꮫࢆᇶ┙࡜ࡋ࡚ゎ᫂ࡍࡿࠋࡑࡢࡓࡵ࡟ࠊከᵝ࡞ࣔࢹࣝື≀ࢆ◊✲ᑐ㇟࡜ࡋ࡚ࠊ㑇ఏᏊࡸࢱࣥࣃࢡ㉁ࡢⓎ⌧࡜ᶵ⬟ࢆ⥙⨶ⓗ࡟ゎᯒࡋࠊ⏕≀ࡸ⣽⬊ࢆྲྀࡾᕳࡃ⎔ቃኚ໬ࡀࡑࢀࡽ࡟ᑐࡋ࡚࡝ࡢࡼ࠺࡞ᙳ㡪ࢆ୚࠼ࡿࡢ࠿ࢆ⌮ㄽ⏕≀Ꮫࡢᡭἲ࡟ࡼࡾ᫂ࡽ࠿࡟ࡍࡿ᪂ࡓ࡞◊✲ศ㔝ࠕ⎔ቃᛂ⟅ᡓ␎ࠖࢆ๰ᡂࡍࡿࠋᮏࣉࣟࢪ࢙
ࢡࢺࡣ + ᖺᗘ≉ู⤒㈝㸦඲ᅜඹྠ฼⏝࣭ඹྠᐇ᪋ศ㸧ࠕࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃᛂ⟅ᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖ࡜ࡋ࡚᥇ᢥࡉࢀࠊ௨ୗ࡟♧ࡍ㸲ࡘࡢࠕ⎔ቃᛂ⟅◊✲㡿ᇦࠖࢆタᐃࡋࠊ◊✲ࢆ㐙⾜ࡋ࡚࠸ࡿࠋ㸯㸧᳜≀࡟࠾ࡅࡿ⏕యእ⎔ቃᛂ⟅ᶵᵓ㸸ගࡸᗘ➼ࡢ⏕యእ⎔ቃせᅉࡀගྜᡂ➼ࡢ᳜≀ࡢ⬟ຊ࡟୚࠼ࡿᙳ

㡪࡜ຠᯝࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࠋ㸰㸧ື≀࡟࠾ࡅࡿ⏕యእ⎔ቃᛂ⟅ᶵᵓ㸸ගࠊ ᗘࠊ໬Ꮫ≀㉁➼ࡀື≀ࡢ⏕Ṫᵝᘧࠊᛶࠊ⾜ື➼ࡢ㧗ḟᶵ⬟࡟୚࠼ࡿᙳ㡪࡜ຠᯝࢆ᫂ࡽ
࠿࡟ࡍࡿ◊✲ࠋ㸱㸧᳜≀࡟࠾ࡅࡿ⏕యෆ⎔ቃᛂ⟅ᶵᵓ㸸᳜≀࡜ඹ⏕⏕≀࡜ࡢ┦஫స⏝➼ࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࠋ㸲㸧ື≀࡟࠾ࡅࡿ⏕యෆ⎔ቃᛂ⟅ᶵᵓ㸸ື≀࡜ඹ⏕⏕≀࡜ࡢ┦஫స⏝ࠊෆศἪ࠿ࡃ஘≀㉁ࡢస⏝ᶵᗎゎ᫂ࡢᇶ┙࡜࡞ࡿ࣍ࣝࣔࣥ࡟ࡼ
ࡿᛶࡸ⏕Ṫᵝᘧࡢไᚚᶵᵓ➼ࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࠋᖹᡂ  ᖺᗘࡣࠊ๓ᖺᗘᡤෆබ
ເ࡟ࡼࡾ᥇ᢥࡋࡓ㸴ㄢ㢟㹙㸯㸧㸱ㄢ㢟ࠊ㸰㸧㸰ㄢ㢟ࠊ㸱㸧㸱ㄢ㢟㸦㔜」࠶ࡾ㸧㹛ࡢ◊✲ࢆ᥎㐍ࡍࡿ࡜࡜ࡶ࡟ࠊඹྠ฼⏝◊✲ࡢ୰᰾࡛࠶ࡿࣔࢹࣝ⏕≀◊✲ࢭࣥࢱ࣮ࠊ
⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮࡟ NIBB ࣇ࢙࣮ࣟࢆ㓄⨨ࡋࠊඹྠ฼⏝◊✲యไࡢᙉ໬ࢆᅗࡗ
ࡓࠋࡲࡓࠊᮏ㡿ᇦ࡟㛵㐃ࡍࡿᏘ⠇⏕≀Ꮫ◊✲㒊㛛ࢆ᪂タࡋࠊྜྷᮧᓫ࣭ྡྂᒇ኱Ꮫ
ᩍᤵࢆᐈဨᩍᤵ࡜ࡋ࡚㏄࠼ࠊ◊✲ࢆ㛤ጞࡋࡓࠋ

,9Eࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ ගᏛゎᯒᐊ㸦ட஭≉௵෸ᩍᤵ㸧࡜᫬✵㛫ไᚚ◊✲ᐊ㸦㔝୰෸ᩍᤵ㸧ࡀ୰ᚰ࡜࡞
ࡗ࡚ࠊࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࢆඛᑟࡍࡿ㢧ᚤ㙾ᢏ⾡㛤Ⓨ࡜ࢥ࣑ࣗࢽࢸ࢕࣮࡬ࡢᬑཬ
ࢆ㐍ࡵࡓࠋḟୡ௦ࡢ㢧ᚤ㙾ࢩࢫࢸ࣒࡜ࡋ࡚ࠊࢹࢪࢱࣝࢫ࢟ࣕࣥගࢩ࣮ࢺ㢧ᚤ㙾
㸦DSLM㸧ࡸ㉥እ࣮ࣞࢨ࣮㑇ఏᏊᒁᡤⓎ⌧㢧ᚤ㙾㸦IR-LEGO㸧ࢆ୰ᚰ࡟ྛ✀㢧ᚤ㙾ᢏ⾡ࢆ⏝࠸ࡓඹྠ◊✲㸦௳㸧ࢆ᥎㐍ࡋࡓࠋࡲࡓࠊᶵᵓࡀ᥎㐍ࡍࡿⱝᡭ◊✲⪅࡟ࡼࡿศ㔝㛫㐃ᦠ◊✲ㄢ㢟㸦௦⾲ࡣ⋢⏣ຓᩍ㸧࡛ࡣኳᩥྎ࡛㛤Ⓨࡉࢀࡓ⿵ൾගᏛ⣔− 15 −

ࡢ㢧ᚤ㙾࢖࣓࣮ࢪࣥࢢ࡬ࡢᛂ⏝◊✲ࢆᢏ⾡ⓗഃ㠃࡛ࢧ࣏࣮ࢺࡋࠊᡂᯝࢆᣲࡆࠊࡑ
ࢀࡽᡂᯝࢆⓎ⾲ࡍࡿࢩ࣏ࣥࢪ࣒࢘ࢆ㛤ദࡋࡓࠋࡉࡽ࡟ࠊ๓ᖺᗘࡼࡾ⥅⥆ࡋ࡚ࠊ᪂ศ㔝๰ᡂࢭࣥࢱ࣮࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫ◊✲ศ㔝ࡢ⏬ീ᝟ሗ◊✲⪅㸦ᮌ᳃≉௵ຓᩍࠊຍ⸨≉௵ຓᩍ㸧࡜ඹ࡟࢖࣓࣮ࢪࣥࢢ࡟ࡼࡿᐃ㔞໬ᡭἲࡸゎᯒᡭἲࡢ㛤Ⓨࢆ㐍ࡵࡓࠋࡲࡓࠊྠ◊✲ศ㔝࡜ྜྠ࡛ࠊ⏬ീฎ⌮࣭ゎᯒࡢᇶ♏▱㆑ࡢ⩦ᚓ࠾ࡼࡧ⏬
ീ᝟ሗ◊✲⪅࡜ࡢඹྠ◊✲ࡢಁ㐍ࢆ┠ⓗ࡜ࡋࡓࠕ⏕≀⏬ീࢹ࣮ࢱゎᯒࢺ࣮ࣞࢽࣥ
ࢢࢥ࣮ࢫࠖࢆ㛤ദࡋࠊࡉࡽ࡟ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࣇ࢛࣮࣒ࣛ㸦➨㸶ᅇ┠㸧࡜ࠊᅜෆࡢ࢖࣓࣮ࢪࣥࢢ㛵㐃᪋タ㛫ࡢࢿࢵࢺ࣮࣡ࢡ໬ࢆ㐍ࡵࡿࡓࡵࡢ‽ഛ࡜ࡋ࡚ࡢࠕ඲
ᅜ኱Ꮫ➼ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ㐃ᦠయไࡢ௒ᚋࡢ࠶ࡾ᪉ࢆ⪃࠼ࡿ఍ࠖࢆࢪࣙ࢖ࣥࢺ
ࢩ࣏ࣥࢪ࣒࢘࡜ࡋ࡚㛤ദࡋࠊ᪋タࡢᢸᙜ⪅࡜᳨ウࢆ⾜࠸ࠊ◊✲⪅㛫ࡢ᝟ሗ஺᥮ࡢሙࢆタࡅࢥ࣑ࣗࢽࢸ࢕࣮๰ᡂࢆ┠ᣦࡍ᪉㔪ࢆ☜ㄆࡋࡓࠋ

,9F⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦2%&㸧ࡢ㛤ദ㈨ᩱ 㹎
 OBC ࡣࠊᇶ♏⏕≀Ꮫศ㔝࡟࠾ࡅࡿ᪂ࡋ࠸◊✲ࢸ࣮࣐ࡢⓎ᥀࡜◊✲⪅ࢥ࣑ࣗࢽࢸ
࢕࣮ࡢᙧᡂࢆ┠ᣦࡋ࡚ࠊ ᖺ  ᭶ࡢ➨㸯ᅇ “The Biology of Extinction”ࡼࡾࠊᖺ  ᭶ࡢ➨㸷ᅇ “Marine Biology II͇ࡲ࡛ᖺ㸯ᅇ㛤ദࡋ࡚ࡁࡓ㸦➨㸶ᅇࡀᮾ᪥ᮏ኱
㟈⅏ࡢᙳ㡪୍࡛ᖺᘏᮇ࡜࡞ࡗࡓ㸧ࠋࡇࢀࡣࠊ ྡ⛬ᗘࡢᾏእཧຍ⪅ࢆᣍᚅࡋࠊᅜ
ෆ◊✲⪅ࢆྵࡵ࡚  ྡ⛬ᗘࡀྜᐟࡋ࡚⾜࠺࡜࠸࠺ࠊࣘࢽ࣮ࢡ࡞ࢡ࣮ࣟࢬࢻࡢ
ᅜ㝿఍㆟࡛࠶ࡿࠋᇶ⏕◊ෆእࠊᅜෆእࡢ࣮࢜࢞ࢼ࢖ࢨ࣮ࡀ௻⏬ࡋࡓẖᅇࡢ OBC ࡣ༑ศ࡞ᡂᯝࢆᣲࡆࠊୖグ┠ⓗ࡟㈉⊩ࡋ࡚᮶ࡓࠋ ࡑࡢ୍᪉ࠊᇶ⏕◊እࡢ◊✲⪅ࡀ୰ᚰ࡜࡞ࡗ࡚࣮࢜࢞ࢼ࢖ࢬࡋ࡚࠸ࡓᙜึࡢᙧែ
࠿ࡽࠊḟ➨࡟ᇶ⏕◊ᡤෆࡢ◊✲⪅ࡢᯝࡓࡍẚ㔜ࡀ኱ࡁࡃ࡞ࡗ࡚᮶ࡓࠋࡲࡓࠊࡸࡴ
ࢆᚓ࡞࠸ண⟬つᶍࡢ⦰ᑠ࡟ࡼࡗ࡚ࠊᒸᓮᆅ༊࡛㛤ദࡍࡿሙྜࡀከࡃ࡞ࡗ࡚࠸ࡿࠋ
ࡑࡢ⤖ᯝࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡟ᛶ᱁ࡀ㏆࡙࠸࡚᮶ࡓ࡜࠸࠺ᣦ᦬ࡀ࠶ࡗࡓ㸦NIBB
ࢥࣥࣇ࢓ࣞࣥࢫࡣᡤෆࡢ◊✲⪅ࡀ୰ᚰ࡜࡞ࡗ࡚࣮࢜࢞ࢼ࢖ࢬࡋ࡚ࠊẚ㍑ⓗ☜❧ࡋࡓ◊✲ࢸ࣮࣐࡟㛵ࡋ࡚ᅜෆእࡢ◊✲⪅ࢆ㞟ࡵࡿ࣮࢜ࣉࣥ࡞఍㆟࡛࠶ࡿࠋཎ๎࡜ࡋ
࡚ᒸᓮ࡛㛤ദࡍࡿࠋ㸧ࠋ᭦࡟ࠊ」ᩘࡢᴫ⟬せồ஦ᴗࡀ㉮ࡿ࡞࡝ࠊ᪂ࡋ࠸◊✲ࢸ࣮࣐ࢆ㛤ᣅࡋ࡚◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࢆᙧᡂ࣭⫱ᡂࡍࡿ࡜࠸࠺ᇶ⏕◊ࡢ࣑ࢵࢩࣙࣥ
࡟ࠊ᪂ࡋ࠸ᡭẁࡀຍࢃࡗ࡚᮶ࡓࠋ ࡇࢀࡽࡢ≧ἣࢆ㚷ࡳࠊᖹᡂ  ᖺᗘࡣ OBC 㛤ദࢆぢ㏦ࡾࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ
ࡸࡑࡢ௚ࡢᅜ㝿఍㆟ࡸᅜ㝿㐃ᦠάືࠊ᭦࡟௚ࡢ஦ᴗࢆࡶྵࡵࡓ⥲ྜⓗほⅬ࠿ࡽ
OBC ࡢ㛤ദ᪉㔪ࢆ෌᳨ウࡋࡓࠋࡑࡢ⤖ᯝࠊOBC ࢆẖᖺ㛤ദࡍࡿࡇ࡜࡟ࡣᇳ╔ࡏࡎࠊᅜ㝿఍㆟ࢆ࣮࢜࢞ࢼ࢖ࢬࡍࡿ◊✲⪅㸦ᇶᮏⓗ࡟ᇶ⏕◊ෆࡢ◊✲⪅㸧ࡀࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ࠶ࡿ࠸ࡣ OBC ࢆࠊࡑࢀࡒࢀࡢ఍㆟ࡢ⌮ᛕ࡟ྜ⮴ࡍࡿࡼ࠺࡟㛤ദࡍࡿ࡜− 16 −

࠸࠺᪉㔪ࢆ❧࡚ࡓࠋලయⓗ࡟ࡣࠊⴌⱆⓗ࡞ࢸ࣮࣐࡟ࡘ࠸࡚㔝ᚰⓗ࡞㆟ㄽࢆ῝ࡵࡓ࠸᫬ᮇ࡟ࡣ OBC ࢆࠊ☜❧ࡋࡓศ㔝࡛᭱ඛ➃ࡢ᝟ሗࢆඹ᭷ࡋ࡚ศ㔝ࢆ≌ᘬࡍࡿ㆟ㄽࢆ⾜࠺࡟ࡣ NIBB ࢥࣥࣇ࢓ࣞࣥࢫࢆ࣮࢜࢞ࢼ࢖ࢬࡍࡿࡢࡀ㐺ษ࡛࠶ࡿࠋࡇࢀࡽࡢ఍
㆟ࢆ㏻ࡋ࡚ᇶ⏕◊ࡢ◊✲ࣞ࣋ࣝࡀྥୖࡋࠊ୺ᑟⓗᙺ๭ࢆᯝࡓࡍࡇ࡜࡛ᅜෆእࡢࢥ
࣑ࣗࢽࢸ࢕࣮࡟㈉⊩ࡍࡿࡇ࡜ࢆ┠ᣦࡍࠋ,9G᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ ᚑ᮶ࡢࣔࢹࣝ⏕≀࡛ࡣ◊✲ࢆ⾜࠺ࡇ࡜ࡀᅔ㞴࡞⏕࿨⌧㇟ࢆゎ᫂ࡍࡿࡓࡵ࡟ᚲせ࡞ࣔࢹࣝ⏕≀ࢆᅜෆእࡢ◊✲ᶵ㛵࡜㐃ᦠࡋ࡚᪂つ࡟㛤Ⓨࡋࠊࡑࡢ㑇ఏᏊ᝟ሗࢆᩚ
ഛࡍࡿ࡜࡜ࡶ࡟ࠊ㑇ఏᏊᶵ⬟ゎ᫂࡟ᚲせ࡞ᢏ⾡ࡢ㛤Ⓨ࣭ᬑཬࢆ⾜࠺ࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ᮏࢭࣥࢱ࣮ࢆタ⨨ࡋࡓࠋ⌧ᅾࠊᢸᙜᩍဨࡢ㑅⪃࡟ྥࡅ࡚‽ഛࢆ㐍ࡵ࡚࠸ࡿࠋ
᮶ᖺᗘ࠿ࡽᮏ᱁ⓗ࡟◊✲ࢆጞືࡍࡿ࡜࡜ࡶ࡟ࠊࣔࢹࣝ⏕≀ࡢ㣫⫱࣭⦾Ṫ➼ࡢㅮ⩦఍ࠊ᝟ሗᥦ౪ࡢࡓࡵࡢ࣮࣡ࢡࢩࣙࢵࣉࢆ㛤ദࡍࡿணᐃ࡛࠶ࡿࠋ
− 17 −

9ⱝᡭ◊✲⪅ࡢ⫱ᡂ ᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ࡣࠊ⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ࣭ᇶ♏⏕≀Ꮫᑓᨷࡢᇶ┙ᶵ㛵࡜ࡋ࡚኱Ꮫ㝔⏕ࡢᩍ⫱ࢆ⾜࡞ࡗ࡚ࡁࡓࠋࡲࡓࠊ≉ูඹྠ฼⏝◊✲ဨ࡜ࡋ࡚௚኱Ꮫ࠿ࡽ
኱Ꮫ㝔⏕ࢆཷࡅධࢀࠊ኱Ꮫ㝔⏕ᩍ⫱࡟༠ຊ࣭㈉⊩ࡋ࡚࠸ࡿࠋࡇࢀࡽࡢไᗘ࡟ࡼࡾ
ᇶ♏⏕≀Ꮫ◊✲ᡤ࡟ᅾ⡠ࡋࡓᏛ⏕࠿ࡽከࡃࡢேᮦࡀ㍮ฟࡋ࡚࠸ࡿࠋ

9D⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ࡟࠾ࡅࡿ኱Ꮫ㝔ᩍ⫱㈨ᩱ 㹎㸯㸧ᖹᡂ  ᖺᗘࡣࠊ⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ࡜ࡢ㐃ᦠ࡟ࡼࡾࠊᢸᙜᩍဨᘏ࡭  ྡ࡛ࠊ ྡࡢ኱Ꮫ㝔Ꮫ⏕࡟ᑐࡋࠊ⥲ྜᩍ⫱⛉┠㸴ㅮ⩏㸦⏕࿨⛉Ꮫ࡜♫఍ࠊ⛉Ꮫ࣭ᢏ⾡࡜♫఍ࠊ⛉Ꮫ࡟࠾ࡅࡿ♫఍ࣜࢸࣛࢩ࣮ࠊ࣑ࢡ࣭࣐ࣟࢡࣟ⏕≀Ꮫ , ࡜ ,,ࠊ⥲◊኱ࣞࢡࢳ࣮ࣕ㸧࣭㸯ࢭ࣑ࢼ࣮㸦Ꮫ⏕ࢭ࣑ࢼ࣮㸧࡟ຍ࠼ࠊ◊✲⛉ඹ㏻ᑓ㛛⛉┠㸦e-learning㸲⛉┠ྛ㸯༢఩ࠊ⏕࿨⛉Ꮫࢭ࣑ࢼ࣮>◊✲ᡤෆ࡛⾜ࢃࢀࡿࢭ࣑ࢼ࣮࡬ࡢཧຍ㸸㸯༢఩㹛㸧ࠊᑓᨷ㛫⼥ྜࣉࣟࢢ࣒ࣛ㸦⬻⛉Ꮫᑓᨷ㛫⼥ྜࣉࣟࢢ࣒ࣛ㹙 ㅮ⩏⛉┠ྛ㸯༢఩㹛ࠊ⤫ྜ⏕࿨⛉Ꮫᩍ⫱ࣉࣟࢢ࣒ࣛ㹙㸲ㅮ⩏⛉┠ྛ㸰༢఩ࠊ㸵ㅮ⩏⛉┠ྛ㸯༢఩㸸ὀ 㹛㸧ࠊᑓᨷᑓ㛛⛉┠㸦ᇶ♏⏕≀Ꮫᴫㄽ㹙඲ᩍဨ࡟ࡼࡿ࣒࢜ࢽࣂࢫᙧᘧㅮ⩏㸲༢఩㹛ࠊ⣽⬊⏕≀Ꮫ㹙㸯༢఩㹛ࠊⓎ⏕⏕≀Ꮫ㹙㸯༢఩㹛ࠊᇶ♏⏕≀Ꮫⱥㄒཱྀㄒ
⾲⌧₇⩦㹙㸯༢఩㸸ὀ 㹛ࠊᇶ♏⏕≀Ꮫⱥㄒ➹グ⾲⌧₇⩦㹙e-learning㸯༢఩㹛ࠊ࢔ࢻࣂࣥࢫࢥࣥࣇ࢓ࣞࣥࢫ㹙NIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡬ࡢཧຍ㸸㸯༢఩㹛㸧ࡢㅮ⩏ࢆ㛤ㅮࡋࡓࠋࡲࡓࠊ⏕࿨⛉Ꮫࣉࣟࢢࣞࢫ₇⩦㸦᪥ᖖⓗ࡞◊✲ᣦᑟ㸸㸲༢఩ࠊὀ 㸧ࠊ⏕࿨⛉Ꮫᐇ㦂₇⩦㸦᪥ᖖⓗ࡞ᐇ㦂ᣦᑟ㸸㸲༢఩㸧ࠊ⏕࿨⛉Ꮫㄽᩥ₇⩦㸦᪥ᖖⓗ࡞ㄽᩥ㉎ㄞࠊᇳ➹ᣦᑟ㸸㸲༢఩㸧ࢆ⾜࠸㐺ษ࡟༢఩ㄆᐃࡋࡓࠋ኱Ꮫ㝔ᅜ㝿໬ࡢࡓࡵࠊ
እᅜேᏛ⏕ࡢཧຍࡍࡿㅮ⩏ࡣⱥㄒ࡛⾜ࡗࡓࠋࡇࢀࡽࡢㅮ⩏ࡢࢩࣛࣂࢫ࡟ࡘ࠸࡚ࠊ
ᑓᨷ࣮࣒࣮࣍࣌ࢪࢆぢࡸࡍࡃᨵⰋࡋࡓࠋ㸦ὀ 㸧⥲◊኱ࡢ≉㉁ࢆ⏕࠿ࡋࠊ」ᩘᑓᨷ࡟ࡼࡿඹ㏻ᩍ⫱⛉┠ࡢ㐲㝸ㅮ⩏ࢩࢫࢸ࣒ࢆ฼⏝ࡋ࡚㛤ㅮࡋࡓࠋ㸦ὀ 㸧ᇶ♏⏕≀Ꮫⱥㄒཱྀㄒ⾲⌧₇⩦࡜ࡋ࡚ࠊⱥ఍ヰࠊⱥㄒࣉࣞࢮࣥࢸ࣮ࢩࣙࣥ⬟ຊྥୖࡢࡓࡵእᅜேㅮᖌࢆ㞠⏝ࡋࠊ㏻ᖺࠊᏛ⏕ࡢᩍ⫱ࢆ⾜ࡗࡓࠋ㸦ὀ 㸧⏕࿨⛉Ꮫࣉࣟࢢࣞࢫ₇⩦ࡢ୍㒊࡜ࡋ࡚ࠊ」ᩘᣦᑟᩍဨไ࡟ࡼࡗ࡚ࠊᖺ㸰ᅇࠊᏛ⏕㸯ྡ࠶ࡓࡾ㸲ྡࡢᩍဨ࡜ࡢ㠃ㄯࢆ⾜ࡗࡓࠋࡲࡓࠊ㸰ᖺḟ࡜㸲ᖺḟࡢᏛ⏕࡟ࡼࡿ࣏ࢫࢱ࣮Ⓨ⾲఍ࢆ㛤ദࡋࠊᢸᙜᩍဨ࡟ຍ࠼ࠊ඲ᩍဨ࡟ࡼࡿᣦᑟࢆ⾜ࡗࡓࠋ㸰㸧㸱ྡ㸦ෆ㸯ྡࡣㄽᩥ༤ኈ㸧࡟ᑐࡋ༤ኈࡢᏛ఩ࢆᤵ୚ࡋࡓࠋ
㸱㸧㸷ྡࡢ≉ูඹྠ฼⏝◊✲ဨࢆ௚኱Ꮫ࠿ࡽཷࡅධࢀࡓࠋ
㸲㸧኱Ꮫ㝔⏕㸦≉ูඹྠ฼⏝◊✲ဨࢆྵࡴ㸧࡟ࡣࣜࢧ࣮ࢳ࢔ࢩࢫࢱࣥࢺไᗘ࡟ࡼ

− 18 −

ࡾࠊᖺ㛫⣙  ୓෇ࡢ཰ධࡀᚓࡽࢀࡿࡼ࠺࡟ࡋࡓࠋࡲࡓࠊධヨᡂ⦼ඃ⚽࡞Ꮫ⏕࡟ᤵᴗᩱච㝖㸦㸳ᖺ୍㈏ไ༤ኈㄢ⛬ࠊ༤ኈᚋᮇㄢ⛬ྛ㸯ྡྛ༙㢠㸧ࢆ⾜ࡗࡓࠋࡇࢀࡽ
ࡢไᗘ࡟ࡘ࠸࡚ཷ㦂⏕ྥࡅ࣮࣒࣮࣍࣌ࢪ࡟ᥖ㍕ࡋࡓࠋ㸳㸧㸯Ἡ㸰᪥ࡢྜྠࢭ࣑ࢼ࣮㸦ࣜࢺ࣮ࣜࢺ㸧ࢆ㑇ఏᏛᑓᨷࠊ⏕⌮⛉Ꮫᑓᨷࠊ⏕࿨ඹ⏕య㐍໬Ꮫᑓᨷ࡜ඹྠ㛤ദࡋࠊᩍဨࠊᏛ⏕࡜ࡢ஺ὶࢆಁ㐍ࡋࡓࠋ㸴㸧ᅜෆ኱Ꮫ⏕࣭኱Ꮫ㝔⏕ࢆᑐ㇟࡜ࡋࠊ኱Ꮫ㝔ㄝ᫂఍㸦ᮾி㸰ᅇࠊᒸᓮ㸰ᅇࡢྜィ࡛ྡࡀཧຍ㸧ࠊయ㦂ධᏛ㸦ྡࡀཧຍ㸧ࢆ㛤ദࡋࡓ㈨ᩱ㹎ࠋ㸵㸧NIBB࢖ࣥࢱ࣮ࣥࢩࢵࣉไᗘ㸦࢖ࣥࢻࡼࡾ㸯ྡࠊ୰ᅜࡼࡾ㸰ྡࠊࣂࣥࢢࣛࢹࢩ
ࣗࡼࡾ㸯ྡࠊࣁ࣮ࣥ࢞ࣜࡼࡾ㸯ྡࢆᘏ࡭⣙㐌㛫ཷࡅධࢀ㸧ࢆά⏝ࡋࠊᅜእ࠿ࡽ
ࡢ␃Ꮫ⏕☜ಖ࡟ດࡵࡿ࡜࡜ࡶ࡟ࠊᅾᏛ⏕ࡢᅜ㝿໬࡟ᙺ❧࡚ࡓ㈨ᩱ㹎ࠋ㸶㸧᫖ᖺ࡟ᘬࡁ⥆ࡁࠕ኱Ꮫ⏕ࡢࡓࡵࡢኟࡢᐇ⩦ࠖࢆ㛤ദࡋࡓࠋྡࡢᏛ㒊Ꮫ⏕ࡀཧຍࡋࡓ㈨ᩱ㹎ࠋ
9E௚኱Ꮫ࡜ࡢ㐃ᦠ㸯㸧ᇶ♏⏕≀Ꮫ◊✲ᡤࡀ㐃ᦠᶵ㛵࡜ࡋ࡚ཧ⏬ࡍࡿྡྂᒇ኱Ꮫ༤ኈㄢ⛬ᩍ⫱࣮ࣜࢹ࢕ࣥࢢ኱Ꮫ㝔ࣉࣟࢢ࣒ࣛࠕࢢ࣮ࣜࣥ⮬↛⛉Ꮫᅜ㝿ᩍ⫱◊✲ࣉࣟࢢ࣒ࣛࠖ
㸦⌮Ꮫ◊✲⛉࣭⏕࿨㎰Ꮫ◊✲⛉࣭ᕤᏛ◊✲⛉㸧ࡢάືࡢ୍⎔࡜ࡋ࡚ࠊ㸰ྡࡢ◊✲⪅ࡀྡྂᒇ኱Ꮫ࡟ฟྥࡁࠊ⌮Ꮫ◊✲⛉⏕࿨⌮Ꮫᑓᨷࡢ኱Ꮫ㝔⏕ྥࡅࡢ㞟୰ㅮ⩏ࢆ⾜࡞ࡗࡓࠋࡲࡓࠊྛ኱ᏛࡢᏛ㒊Ꮫ⏕ࡀࠊ༞ᴗ◊✲ࢆᇶ♏⏕≀Ꮫ◊✲ᡤࡢ௵ពࡢ◊✲㒊㛛࡟࠾࠸࡚⾜࡞࠺ࡇ࡜ࡀ࡛ࡁࡿไᗘ㸦≉ูᐇ⩦⏕ཷࡅධࢀไᗘ㸧ࢆ᪂ࡓ࡟タࡅࠊ௒ᖺᗘ
ࡣྡྂᒇ኱Ꮫ࠾ࡼࡧᮾி⌮⛉኱Ꮫ࠿ࡽࡑࢀࡒࢀ㸯ྡࡎࡘࡢᏛ⏕ࢆཷࡅධࢀࡓࠋ
㸰㸧ྡྂᒇᕤᴗ኱Ꮫ࡜ࡢ㛫࡛ྜྠ㛤ദࡋࡓࠕⓎ⏕࣭⏕యᙧᡂࡢࣂ࢖࣓࢜࢝ࢽࢡࢫࠖ
࡟㛵ࡍࡿ㐃ᦠ◊✲ࢭ࣑ࢼ࣮ࢆࡶ࡜࡟㛤ጞࡉࢀࡓඹྠ◊✲ࡀ㡰ㄪ࡟㐍ࡳࠊࡑࡢᡂᯝ
࡟ࡼࡗ࡚Ꮫ఩ྲྀᚓ⪅㸦ಟኈ㸧ࡶ⏕ࡲࢀࡓࠋ

− 19 −

㸰㸬ᑗ᮶ィ⏬㸦኱つᶍ◊✲ィ⏬ࠊᴫ⟬せồ㸧 ᇶ♏⏕≀Ꮫ◊✲ᡤࡣ᪥ᮏᏛ⾡఍㆟ࠕᏛ⾡ࡢ኱ᆺ᪋タィ⏬࣭኱つᶍ◊✲ィ⏬ࠖ࡜ࡋ࡚ࠕ⏕≀ࡢ⎔ቃ㐺ᛂᡓ␎ゎ᫂ࡢࡓࡵࡢ኱Ꮫ㐃ᦠ◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡࡢᙧᡂࠖ
ࢆ┠ᣦࡍ኱つᶍࣉࣟࢪ࢙ࢡࢺࢆ⏦ㄳࡋ࡚࠾ࡾ㈨ᩱ 㹎ࠊࡇࡢࣉࣟࢪ࢙ࢡࢺࢆᨭ࠼ࡿ
ᇶ┙஦ᴗ࡜ࡑࡢタഛᩚഛࢆ┠ᣦࡋࡓᴫ⟬せồࢆ㐍ࡵ࡚࠸ࡿ㈨ᩱ 㹎ࠋᖹᡂ  ᖺᗘࡼࡾࠕࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖࠊྠᖺᗘ
⿵ṇண⟬࡟ࡼࡿࠕ኱Ꮫ➼࡟࠾ࡅࡿ⏕≀㈨※ࡢࣂࢵࢡ࢔ࢵࣉᩚഛࠖࡀㄆࡵࡽࢀࡿ࡜
࡜ࡶ࡟ࠊᖹᡂ  ᖺᗘ࠿ࡽ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࡀⓎ㊊ࡋࠊ⏕≀㈨※ࣂࢵࢡ࢔ࢵࣉయไࡢᵓ⠏ࢆ㐍ࡵ࡚࠸ࡿࠋᖹᡂ  ᖺᗘࡢᴫ⟬せồ࡛ࡣࠕࣔࢹ
ࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖࡢ⥅⥆࡜࡜ࡶ࡟ࠊ
኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࡢቑ㢠せồࡀㄆࡵࡽࢀࡓࠋࡇࡢቑ㢠࡟ࡼࡾࠊ᪂つ෾⤖ಖᏑᢏ⾡ࢆ㛤Ⓨ࣭◊✲ࡍࡿඹྠ฼⏝◊✲ࢆ㛤ጞࡋࡓࠋࡲࡓࠊ᪂つࣉࣟࢪ࢙ࢡࢺ࡛࠶ࡿࠕ኱Ꮫ㐃ᦠ࡟ࡼࡿ᪂つࣔࢹࣝ⏕≀ࡢ㛤ⓎᣐⅬᙧᡂࠖࡀ᥇ᢥࡉ
ࢀࠊ᪂ࡓ࡟᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࡀタ❧ࡋࠊయไᩚഛ࡟╔ᡭࡋࡓࠋࡑࡢᇶ┙ⓗタഛᩚഛࠕ␗ศ㔝⼥ྜ࡟ࡼࡿ⏕≀ࡢ㐺ᛂ⬟ຊࡢ◊✲ࡢ๰ᡂ࡟ྥࡅࡓከඖⓗ⏕≀᝟ሗࡢ⤫ྜゎᯒࢩࢫࢸ࣒ࠖཬࡧࠕྠࢩࢫࢸ࣒⏝㔝እᆺ⢭ᐦ⎔ቃไᚚ⿦⨨ࠖࡀᖹᡂ  ᖺᗘࡢ⿵ṇண⟬࡟ࡼࡾᩚഛࡉࢀࠊື≀ࠊ᳜≀ࠊỈ⏕⏕≀ࡢ⎔ቃ㐺ᛂ⬟ຊࡢ◊✲࡟㈨ࡍࡿ⏕⫱᪋タࠊタഛࡀᑟධࡉࢀࡓࠋಶࠎࡢᴫ⟬せồ஦ᴗࡢᴫせࡣ௨ୗࡢ㏻
ࡾ࡛࠶ࡿࠋ
㸯㸧ࠕࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖ㸦ᖹᡂ㸰㸱ᖺᗘ᥇ᢥ㸧㈨ᩱ 㹎 ⏕≀ࡣ⎔ቃࡢᙳ㡪ࢆཷࡅ⏕⫱ࡋ࡚࠸ࡿࠋࡇࡢࡼ࠺࡞⎔ቃᛂ⟅࡟࠾ࡅࡿ㑇ఏᏊⓎ⌧ࡢኚ໬ࢆࠊࢤࣀ࣒᝟ሗࢆᇶ┙࡜ࡋ࡚⥙⨶ⓗ࡟ゎᯒࡍࡿࡇ࡜࡟ࡼࡾࠊ⏕࿨ࡢᮏ㉁࡜ࡶ࠸࠼ࡿ⏕࿨࡜⎔ቃ࡜ࡢ┦஫స⏝ࠊ༶ࡕ⏕≀ࡢ⎔ቃᛂ⟅ᡓ␎ࢆ᫂ࡽ࠿࡟ࡍࡿ᪂
ࡓ࡞◊✲ศ㔝ࢆ๰ᡂࡍࡿࠋ
㸰㸧ࠕ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࠖ㸦ᖹᡂ㸰㸱ᖺᗘ⿵ṇࠊᖹᡂ㸰㸲ᖺᗘ᥇ᢥࠊᖹᡂ㸰㸳ᖺᗘቑ㢠㸧 ᮾ᪥ᮏ኱㟈⅏࡟ࡼࡾࠊከࡃࡢ⏕≀㑇ఏ㈨※ࡀẋᦆ࣭ᾘኻࡋ࡚࠸ࡿࠋࡑࡢࡓࡵࠊ
㏵⤯࠼ࡿ࡜஧ᗘ࡜᚟ඖࡀ࡛ࡁ࡞࠸ᡃࡀᅜࡢᵝࠎ࡞ศ㔝ࡢ◊✲࡟ᚲせ୙ྍḞ࡞᭷⏝
࡛Ⰻ㉁࡞⏕≀㑇ఏ㈨※ࢆᏳᐃⓗ࡟౪⤥ࡍࡿࡓࡵࡢࣂࢵࢡ࢔ࢵࣉᣐⅬࢆᵓ⠏ࡋ࡚ࠊ⏕≀㑇ఏ㈨※ࡢಖᏑ͌⟶⌮యไࢆ⥅⥆ⓗ࡟ᩚഛ͌ᙉ໬ࡍࡿࠋຍ࠼࡚ࠊ㧗ᗘࡢရ㉁⟶− 20 −

⌮ࢆ⾜࠺ࡇ࡜࡟ࡼࡾࠊࣂࢵࢡ࢔ࢵࣉಖᏑࡍࡿ⏕≀㑇ఏ㈨※ࡢ௜ຍ౯್ࢆ≉ẁ࡟ྥୖࡉࡏࠊ㧗ᗘ࡞◊✲࡟⪏࠼ᚓࡿ㧗࠸ࢡ࢜ࣜࢸ࢕࣮ࢆ⥔ᣢࡍࡿࡇ࡜࡛ࠊྛ኱Ꮫ➼ࡢಶูࡢ◊✲࡟ࡼࡗ࡚๰ฟࡉࢀࡓ㈗㔜࡞⏕≀㈨※ࢆ⤌⧊ⓗ࡟Ⓨᒎࡉࡏࠊ኱Ꮫ㛫㐃ᦠ࡟ࡼࡿඹྠ◊✲ࡢᇶ┙ࢆᙉ໬ࡍࡿࠋࡉࡽ࡟ࠊከᵝ࡞⏕≀㑇ఏ㈨※ࢆᏳᐃࡋ࡚ࣂࢵ
ࢡ࢔ࢵࣉࡍࡿࡓࡵ᪂つ෾⤖ಖᏑᢏ⾡ࢆ㛤Ⓨࡍࡿࠋ㸱㸧ࠕ኱Ꮫ㛫㐃ᦠ࡟ࡼࡿ᪂つࣔࢹࣝ⏕≀ࡢ㛤ⓎᣐⅬᙧᡂࠖ㸦ᖹᡂ㸰㸳ᖺᗘ᥇ᢥ㸧 ኱Ꮫ㛫㐃ᦠ࡟ࡼࡿ⏕≀Ꮫ◊✲ࡢⓎᒎࡢࡓࡵࠊ᪤Ꮡࡢࣔࢹࣝ⏕≀࡟ࡼࡾ◊✲ࡉࢀ࡚ࡁࡓ⏕≀ࡢඹ㏻ཎ⌮ࡢᯟ࡟཰ࡲࡽ࡞࠸≉ᚩ࠶ࡿ⏕≀ࢆ᪂つࣔࢹࣝ໬ࡋࠊࡑࡢከ
ᵝ࡞⏕≀ᶵ⬟ࡢゎ᫂ࢆ┠ᣦࡋ࡚ከᒙⓗ࡞◊✲ࢆᒎ㛤ࡍࡿồᚰຊ࠶ࡿ◊✲ᣐⅬࢆᙧᡂࡍࡿࠋᮏ஦ᴗࡀ๰ฟࡍࡿ᭷⏝࡞⏕≀㑇ఏ㈨※ࡣࠊ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉ
ࣉࣟࢪ࢙ࢡࢺ࡟ࡼࡗ࡚ಖᏑ࣭ရ㉁⟶⌮ࡉࢀࠊඹྠ฼⏝࣭ඹྠ◊✲࡟ຠᯝⓗ࡟౪ࡏ
ࡽࢀࡿࠋ

㸲㸧
ࠕ␗ศ㔝⼥ྜ࡟ࡼࡿ⏕≀ࡢ㐺ᛂ⬟ຊࡢ◊✲ࡢ๰ᡂ࡟ྥࡅࡓከඖⓗ⏕≀᝟ሗࡢ⤫ྜゎᯒࢩࢫࢸ࣒ࠖ㸦ᖹᡂ㸰㸲ᖺᗘ⿵ṇ㸧 ᮏタഛࡣࠊ᪤Ꮡཬࡧ᪂つࣔࢹࣝ⏕≀ࡢ⏕⫱⎔ቃࢆ⢭ᐦ࡟ไᚚࡋࠊࣛ࢖ࣈ࢖࣓࣮
ࢪࣥࢢࡸ㑇ఏᏊ㸭ࢱࣥࣃࢡ㉁ࡢⓎ⌧ࠊࡉࡽ࡟௦ㅰ≀㉁ࡢࣔࢽࢱࣜࣥࢢ➼࡟ࡼࡾࠊಶయ㸭⤌⧊㸭⣽⬊࡟࠾ࡅࡿ⎔ቃᛂ⟅➼ࢆከඖⓗ࠿ࡘ⤫ྜⓗ࡟ゎᯒࡍࡿ㞟✚タഛ㸦ࢡࣛࢫࢱ࣮ࢩࢫࢸ࣒㸧࡛࠶ࡿࠋྠᵝࡢࢩࢫࢸ࣒ࡣࡇࢀࡲ࡛ᵓ⠏ࡉࢀ࡚࠸࡞࠸ࠋ
ࡇࡢࢩࢫࢸ࣒ࢆᑟධࡍࡿࡇ࡜࡟ࡼࡾࠊᖜᗈ࠸ᇶ♏⏕≀Ꮫศ㔝ࡢ◊✲ࢆ㣕㌍ⓗ࡟᥎㐍ࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡾࠊ኱Ꮫ㛫㐃ᦠ࡟ࡼࡿ⏕≀ᶵ⬟ゎᯒࡢᇶ┙ᙉ໬ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࠋ
㸳㸧ࠕྠࢩࢫࢸ࣒⏝㔝እᆺ⢭ᐦ⎔ቃไᚚ⿦⨨ࠖ㸦ᖹᡂ㸰㸲ᖺᗘ⿵ṇ㸧 ⮬↛⛉Ꮫ◊✲ᶵᵓᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ࡣࠊ⏕≀ࡢ⏕⫱⿦⨨࡜ゎᯒ⿦⨨ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡟ࡼࡾࠊ⏕≀ࡢ⎔ቃᛂ⟅࡟㛵ࡋ࡚ከࡃࡢ▱ぢࢆ⵳✚ࡋ࡚ࡁࡓࠋ᳜≀ࡢ⎔ቃᛂ⟅ࢆ◊✲ࡍࡿୖ࡛ࠊ㛗ᮇ࡟ࢃࡓࡾ⢭ᐦ࡟⏕⫱⎔ቃࢆไᚚࡋ࡚ಶయࡢᛂ⟅ࢆࣔࢽࢱࣜࣥࢢࡍࡿࡇ࡜ࡀᚲ㡲࡛࠶ࡿࠋࡑࡇ࡛ࠊ㔝እࡢග⎔ቃୗ࡛ከᵝ࡞⏕⫱⎔ቃࢆไᚚ࡛ࡁࠊ࠿ࡘࠊ࢚࢘ࣈ࣓࢝ࣛ࡟ࡼࡾಶయࡢᛂ⟅ࢆ㐲㝸࠿ࡽࣔࢽࢱࣜࣥࢢ࡛ࡁ
ࡿ㔝እᆺ⢭ᐦ⎔ቃไᚚ⿦⨨ࢆᩚഛࡋࠊ᳜≀ࡢ⎔ቃ㐺ᛂᡓ␎ࡢ㣕㌍ⓗ࡞᥎㐍ࢆᅗࡿࠋ

− 21 −

㸱㸬◊✲ຊᙉ໬ᡓ␎ᐊࡢ᪂タ ⮬↛⛉Ꮫ◊✲ᶵᵓࡣᅜ㝿ඹྠ◊✲ࢆ㏻ࡌ࡚ࠊ㸯㸧ୡ⏺᭱㧗Ỉ‽ࡢ⮬↛⛉Ꮫ◊✲ࡢ᥎㐍࡜ࠊ㸰㸧ୡ⏺᭱ඛ➃ࡢඹྠ฼⏝࣭ඹྠ◊✲⎔ቃࢆ⏝࠸ࡓᡃࡀᅜࡢ኱Ꮫ➼ࡢ◊✲ຊᙉ໬࡬ࡢᐤ୚ࡢ㸰ࡘࡢ┠ᶆࢆ㐩ᡂࡍࡿࡓࡵࠊ◊✲ຊᙉ໬᥎㐍஦ᴗࢆ㛤ጞࡋࡓࠋ◊✲ຊᙉ໬ࡢ㸲ࡘࡢᰕ࡜ࡋ࡚ࠊ㸯㸧ᅜ㝿ⓗඛ➃◊✲ࡢ᥎㐍ᨭ᥼ࠊ㸰㸧ᅜෆࡢඹྠ฼⏝࣭ඹྠ◊✲ࡢ᥎㐍ᨭ᥼ࠊ㸱㸧ᅜෆእ࡬ࡢ᝟ሗⓎಙ࣭ᗈሗຊᙉ໬ࠊ㸲㸧◊✲⪅ᨭ᥼㸦ⱝᡭ࣭ዪᛶ࣭እᅜே㸧࡜ࠊ⮬↛⛉Ꮫ⣔◊✲ຊᙉ໬ࢿࢵࢺ࣮࣡ࢡࡢᵓ⠏࠿ࡽ࡞ࡿ◊✲ຊᙉ໬஦ᴗࢆ⾜࠸ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓࡢ◊✲ຊࡢᙉ໬ࢆᅗࡿ࡜࡜ࡶ
࡟኱Ꮫ➼ࡢ◊✲ຊᙉ໬࡟ࡶ㈉⊩࡛ࡁࡿࡼ࠺άືࢆ㐍ࡵ࡚࠸ࡿࠋ ᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ࡣ⮬↛⛉Ꮫ◊✲ᶵᵓࡢ◊✲ຊᙉ໬ᡓ␎ᮏ㒊࡜㐃ᦠࡋ࡚ࠊྠ
஦ᴗࢆ᥎㐍ࡍࡿ◊✲ຊᙉ໬ᡓ␎ᐊࢆタ⨨ࡋࠊᚑ᮶ࡢ᝟ሗᡓ␎ᐊࠊᗈሗᐊ࡜ᅜ㝿㐃ᦠᐊࢆホ౯࣭᝟ሗࠊᗈሗཬࡧᅜ㝿㐃ᦠࢢ࣮ࣝࣉ࡜ࡋ࡚࡜ࡾ㎸ࡴ࡜࡜ࡶ࡟ࠊ᪂ࡓ࡟
ඹྠ฼⏝◊✲ࠊ⏨ዪඹྠཧ⏬᥎㐍ࡢࢢ࣮ࣝࣉࢆ㓄⨨ࡋࠊᇶ⏕◊ࡢ◊✲ຊᙉ໬ࡢά
ືࢆ⾜ࡗ࡚࠸ࡿࠋ ඹྠ฼⏝◊✲ࢢ࣮ࣝࣉ࡛ࡣࠊ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮࡟ࠊ㧗ឤᗘ EM-CCDP ࣓࢝ࣛࢩࢫࢸ࣒ࠊ㉁㔞ศᯒ⏝ࢱࣥࣃࢡ㉁ྠᐃࢯࣇࢺࠊศගගᗘィ➼ࢆᑟධࡋ࡚ඹྠ฼
⏝ࡢ฼౽ᛶྥୖ࡟౪ࡋࡓࠋ ⏨ዪඹྠཧ⏬᥎㐍ࢢ࣮ࣝࣉࡣࠊዪᛶ◊✲ᩍ⫱⫋ဨࡢ✚ᴟⓗ࡞Ⓩ⏝ࢆᅗࡿ┠ⓗ࡛ዪᛶ෸ᩍᤵࢆ㸯ྡබເࡍࡿࡇ࡜࡟࡞ࡗࡓࡇ࡜ࢆཷࡅࠊ◊✲ᡤࡸ㛵㐃Ꮫ఍ࡢ࣮࣒࣍
࣮࣌ࢪ࡞ࡽࡧ࡟㞧ㄅ➼ࢆ㏻ࡌ࡚ࠊᮏே஦࡟㛵ࡍࡿ✚ᴟⓗ࡞ᗈሗάືࢆ⾜ࡗࡓࠋࡲࡓࠊฟ⏘ࡸ⫱ඣ࡟ಀࢃࡿዪᛶ◊✲⫋ဨࢆᨭ᥼ࡍࡿ࢔࢝ࢹ࣑ࢵࢡ࢔ࢩࢫࢱࣥࢺไᗘ
࡬ࡢ⏦ㄳࡀ㸯௳࠶ࡗࡓࡓࡵࠊࡑࡢᡭ⥆ࡁࡸ㐠⏝➼࡟ࡘ࠸࡚ࡢຓゝ࡜ᨭ᥼ࢆ⾜ࡗࡓࠋࡉࡽ࡟ࠊ⏨ዪඹྠཧ⏬ࡢ᥎㐍࡟㛵ࡍࡿၨⵚάື࡜ࡋ࡚ࠊᒸᓮ㸱ᶵ㛵ࡢ௚◊✲ᡤ࡜ࡢඹദ࡛እ㒊ࡢᑓ㛛ᐙ࡟ࡼࡿㅮ₇఍ࢆ⾜࠺࡜࡜ࡶ࡟ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓࡢ௚◊✲ᡤ࡜༠ຊࡋ࡚⏨ዪඹྠཧ⏬᥎㐍ࣃࣥࣇࣞࢵࢺࢆస〇ࡋࡓࠋࡉࡽ࡟ࠊዪᛶ◊✲ᩍ⫱⫋ဨࢆ✚ᴟⓗ࡟Ⓩ⏝ࡍࡿࡓࡵ࡟ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ࣭ᶵᵓ㛗ࡢ࣮ࣜࢲ࣮ࢩࢵࣉࡢ
ࡶ࡜ࠊᶵᵓࡢྛ◊✲ᡤ࡜࡜ࡶ࡟ࠊዪᛶ࡟㝈ᐃࡋࡓ◊✲ᩍ⫱⫋ဨࡢබເࢆ⾜ࡗࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤ࡟࠾࠸࡚ࡣ෸ᩍᤵࢆ㸯ྡබເࡍࡿࡇ࡜࡜ࡋࠊ◊✲ᡤࡸ㛵㐃Ꮫ఍ࡢ࣮࣒࣮࣍࣌ࢪ࡞ࡽࡧ࡟㞧ㄅ➼ࢆ㏻ࡌ࡚✚ᴟⓗ࡞ᗈሗάືࢆ⾜ࡗࡓ⤖ᯝࠊ ྡࡢᛂເࡀ࠶ࡗࡓࠋே஦㑅⪃ᑠጤဨ఍࠾ࡼࡧ㑅⪃఍㆟࡟࠾ࡅࡿᑂ㆟ࢆ⤒࡚ࠊ㏆ࡃ᭱⤊ೃ⿵⪅ࡀỴᐃࡉࢀࡿணᐃ࡛࠶ࡿࠋ
− 22 −

２．基礎生物学研究所の概要− 23 −

− 25 −− 26 −

− 27 −

− 28 −

− 29 −

− 30 −

ဃཋೞᏡᚐௌǻȳǿȸȢȇȫဃཋᄂᆮǻȳǿȸဃཋƷೞᏡǛ‫ٶ‬᩿ႎƴᚐௌƢǔƨǊƷೞ֥ŴȐǤǪǤȡȸǸȳǰƷƨǊƷ᫋ࣇᦟŴᐔ‫ٻ‬ƳȇȸǿǛᚐௌƢǔƨǊƷऴ‫إ‬ϼྸೞ֥ǛஊƠŴဃཋೞᏡᚐௌƷૼƨƳ૾ඥᛯƷ᧏ႆǛᘍƬƯƍǇƢŵ

ᡲઃဃཋೞᏡऴ‫إ‬Ўௌܴᆔ᫏ӨƴƷǅǔ‫ٶ‬ಮƳЎௌೞ֥Ǜ৑ϋ‫ٳ‬Ʒᄂᆮᎍƴ੩̓ŵཎƴŴഏɭˊǷȸǯǨȳǵȸǍЎௌೞǛМဇƠƨೞᏡȟǯǹƴщǛλǕƯƍǇƢŵ

ȢȇȫဃཋσӷМဇᄂᆮƷɶఋਗໜƱƠƯȐǤǪȪǽȸǹȗȭǸǧǯȈᲢᲣƱǋᡲઃƠŴಮŷƳȢȇȫဃཋǛᏋ঺᫫Ꮛŵ‫׎‬ϋ‫ٳ‬ƷȢȇȫဃཋᄂᆮǛǵȝȸȈƢǔ˳СǛૢƑƯƍǇƢŵ

Ȣȇȫѣཋᄂᆮૅੲܴ

Ȫǽȸǹ
ȎǦȏǦ
Ʒ੩̓

ഏɭˊǷȸǯǨȳǵȸ
ഏɭˊǷ
ǯ ȳǵ

Ռʐѣཋ᫫Ꮛ᧏ႆૅੲȦȋȃȈŴ‫׹ݱ‬ᮄ᫏᫫Ꮛ᧏ႆૅੲȦȋȃȈŴȢȇȫѣཋᚐௌૅੲ
ȦȋȃȈŴȡȀǫȐǤǪȪǽ
ȸǹȦȋȃȈƷᲮܴƔǒ঺ǓŴ‫׎‬ϋ‫ٳ‬ƷȢȇȫѣཋᄂᆮǛǵȝȸȈƠƯƍǇƢŵ
ȡȀǫƷɶఋೞ᧙Ǜਃ࢘ƠƯƍǇƢŵ᳍᳊᳀ȞǦǹ᫫Ꮛ౐ή‫ܖ‬ᚐௌܴ
ȷ‫׹ٻ‬ǹȚǯȈȭǰȩȕ
ɭမஇ᭗ǯȩǹƷЎή֥ưƋǓŴဃཋ‫ܖ‬Ʒᄂᆮƴᧈ࠰̅ǘǕƯƍǇƢŵƜƜƔǒ‫ٶ‬ƘƷ᣻ᙲƳႆᙸƕƳƞǕƯƍǇƢŵ
‫׹ٻ‬ǹȚǯȈȭǰȩȕ
ȷή‫ܖ‬᫋ࣇᦟ᫏
ӲᅈƷσ໰ໜȬȸǶȸ᫋ࣇᦟŴʚή‫܇‬᫋ࣇᦟŴᲢȇǸǿȫឥ௹‫׹‬ȩǤȈǷȸȈ᫋ࣇᦟᲣŴᲢហ‫ٳ‬ȬȸǶȸᢡˡ‫܇‬ႆྵ᫋ࣇᦟᲣƳƲǛ̬ஊƠŴ৑ϋȷ৑‫ٳ‬Ʒᄂᆮᎍƕଐࠝႎσ໰ໜ᫋ࣇᦟ
ƴσӷМဇƠƯƍǇƢŵ

ऴ‫إ‬ሥྸᚐௌܴ
σஊȡȢȪ‫׹‬ᚘምǵȸȐƱЎ૝ϼྸဇᚘ
ምೞǯȩǹǿǛɼ᠆ƱƠƨžဃཋऴ‫إ‬ᚐௌǷǹȆȠſǛᢃဇƠŴဃཋऴ‫إ‬ƷᚐௌŴȇȸǿșȸǹƷನሰŴᚐௌȄȸȫƷ᧏ႆŴဒ΂ᚐௌ ဃཋऴ‫إ‬ᚐௌǷǹȆȠϼྸƷૅੲǛᘍƬƯƍǇƢŵ ȇǣǹǯǢȬǤᘺፗ২ᘐᎰՃƴǑǔǵȝȸȈǍᄂᆮᎍƴǑǔяᚕȝᚐௌ২ᘐǵȝ Ȉᚐௌ২ᘐǵȝȸȈȢȇȫౡཋᄂᆮૅੲܴ
‫ٶ‬ಮƳౡཋƷఎؔǛૅੲƠƯƍǇƢŵࠢ࠼ƍ࿢‫ؾ‬ǛϐྵưƖǔఎؔ଀ᚨǛͳƑŴ
ǢǵǬǪƷЎਃೞ᧙ǋਃ࢘ƠƯƍǇƢŵ

σӷМဇᄂᆮሁƴǑǔ৑‫ٳ‬ᄂᆮᎍƷӖλǕȷ᣻ໜσӷМဇᄂᆮȷȢȇȫဃཋȷ২ᘐ᧏
ႆσӷМဇᄂᆮ

֥‫ؔܫ‬᫱ᄂᆮૅੲܴ

ȷ̾КσӷМဇᄂᆮኬᏘӏƼ֥‫ؔܫ‬᫱ƴƓƚǔɭမஇ᭗ǯȩǹƷᚨͳƕᚨƚǒǕŴဃཋ‫ܖ‬Ʒᄂᆮƴᧈ࠰̅ǘǕƯƍǇƢŵƜƜƔǒ‫ٶ‬ƘƷ᣻ᙲ֥‫ؔܫ‬᫱ᘺፗ
ƳႆᙸƕƳƞǕƯƍǇƢŵ

ȷ‫׹ٻ‬ǹȚǯȈȭǰȩ
ȕσӷМဇ᬴ܱ
ȷσӷМဇ᬴ܱȷഏɭˊǷȸǱȳǵ σӷМဇ
ǵȸσӷМဇ᬴ܱ

ౡཋఎؔภܴ౐

᫫Ꮛᚨͳȷ᬴ܱ২ᘐƷ੩̓ǍᄂᆮᎍƴǑǔяᚕ᫫Ꮛᚨͳ᬴ܱ২ᘐƷ੩̓ǍᄂᆮᎍƴǑǔяᚕȢȇȫဃཋǛဇƍƨᄂᆮƷǵȝȸȈȢȇȫဃཋǛဇƍƨᄂᆮƷǵȝȈπѪᲢ‫ܖٻ‬ᡲઃȐǤǪȐȃǯ
ǢȃȗȗȭǸǧǯȈᲣǻȳǿȸ࠯঺ᲬᲮ࠰ࡇ᧏ᚨ

− 31 −

ૼᙹȢȇȫဃཋ᧏ႆǻȳǿȸ࠯঺ᲬᲯ࠰ࡇ᧏ᚨ

− 32 −

− 33 −

− 34 −

− 35 −

− 36 −

Physcomitrella patens

Physcomitrella patens− 37 −

− 38 −

− 39 −

− 40 −

− 41 −

− 42 −

３．基礎生物学研究所外部点検評価会議
議事録− 43 −

ᖹᡂ  ᖺᗘᇶ♏⏕≀Ꮫ◊✲ᡤእ㒊Ⅼ᳨ホ౯఍㆟᪥᫬ ᖹᡂ  ᖺ  ᭶  ᪥㸦᭶㸧㹼ሙᡤ ⮬↛⛉Ꮫ◊✲ᶵᵓ㸦ᒸᓮ㸧஦ົࢭࣥࢱ࣮Ჷ㸱㝵 ➨㸯఍㆟ᐊཧຍ⪅ ኴ⏣ 㑥ྐ ᮾி኱Ꮫ኱Ꮫ㝔⥲ྜᩥ໬◊✲⛉ᩍᤵ ᳃  㑳ᜨ ྡྂᒇ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ᩍᤵ ሷぢ ᫓ᙪ ៞᠕⩏ሿ኱Ꮫ་Ꮫ㒊ศᏊ⏕≀Ꮫᩍᤵ 㛗㇂ ಇ἞ ኱㜰኱Ꮫ⺮ⓑ㉁◊✲ᡤᩍᤵ Ⲩᮌ ᘯஅ ᅜ❧㑇ఏᏛ◊✲ᡤᩍᤵ㸦ᡤෆ㸧 ᒣᮏ ṇᖾ ᇶ♏⏕≀Ꮫ◊✲ᡤ㛗 ྜྷ⏣ ᯇ⏕ ◊✲୺ᖿ 㔝⏣ ᫀᬕ ◊✲୺ᖿ ᑠᯘ  ᝅ ◊✲୺ᖿ ஭ཱྀ ὈἨ ◊✲୺ᖿ すᮧ ᖿኵ 85$ ≉௵ᩍᤵグ㘓 ඣ⋢ 㝯἞ ᇶ♏⏕≀Ꮫ◊✲ᡤ෸ᩍᤵ
㈨ᩱ
 ㈨ᩱ㸯 ᇶ♏⏕≀Ꮫ◊✲ᡤᖹᡂ  ᖺᗘᐇ⦼ࡢᴫせ࡜ᑗ᮶ィ⏬㸦ᮏ෉Ꮚ 3㸧 ㈨ᩱ㸰  ᖺⓎ⾲ㄽᩥࣜࢫࢺ㸦ᮏ෉Ꮚ 3㸧 ㈨ᩱ㸱 ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᴫせ㸦ᮏ෉Ꮚ 3㸧
 ㈨ᩱ㸲 እ㒊Ⅼ᳨ホ౯఍㆟࡛ࡢᣦ᦬஦㡯࡜ᑐᛂ㸦ᮏ෉Ꮚ 3㸧
 ㈨ᩱ㸳 እ㒊Ⅼ᳨ホ౯࢔ࣥࢣ࣮ࢺ⤖ᯝ㸦ᮏ෉Ꮚ 3㸧






− 45 −㸦すᮧ㸧 ࡑࢀ࡛ࡣࠊ࠾ࡑࢁ࠸࡟࡞ࡽࢀࡲࡋࡓࡢ࡛ࠊᖹᡂ  ᖺᗘࡢホ౯఍㆟ࢆ㛤ദࡉࡏ࡚࠸
ࡓࡔࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ⚾ࡣ㐍⾜ࢆົࡵࡉࡏ࡚࠸ࡓࡔࡁࡲࡍᇶ⏕◊ࡢすᮧ࡛ࡍࠋࡲࡎึࡵ࡟
ᒣᮏᡤ㛗࠿ࡽࡈᣵᣜ࠸ࡓࡔࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ᡤ㛗ࡢᒣᮏ࡛ࡈࡊ࠸ࡲࡍࠋ࠶࠸࡟ࡃࡢ࠾ኳẼ࡛ࡋࡓࡅࢀ࡝ࡶࠊᖺᗘࡣࡌࡵࡢ࠾ᛁ
ࡋ࠸࡜ࡇࢁࢆ࠾㞟ࡲࡾ࠸ࡓࡔࡁࡲࡋ࡚ㄔ࡟࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋᇶ⏕◊࡛ࡣ㸯ᖺ࡟㸯ᅇࠊ๓ᖺᗘࢆ᣺ࡾ㏉ࡗ࡚እ㒊Ⅼ᳨ホ౯ࢆ⾜ࡗ࡚࠾ࡾࡲࡋ࡚ࠊእ㒊࠿ࡽඛ⏕᪉࡟᮶࡚࠸ࡓࡔ࠸࡚ࠊ
ᇶ⏕◊ࡢάື࡟ࡘ࠸࡚ᚷ៸ࡢ࡞࠸ࡈពぢࢆ㡬ࡃ࡜࠸࠺ሙ࡟࡞ࡗ࡚࠾ࡾࡲࡍࠋ ⚾ࡶ௨๓࡟እ㒊ࡢே㛫ࡔࡗࡓ࡜ࡁ࡟ࡣࠊࡇࡢⅬ᳨ホ౯࡟㸰ᅇཧຍࡉࡏ࡚࠸ࡓࡔࡁࡲࡋ࡚ࠊ
⚾ࡣࡑࢀ࡯࡝ᛮ࠸ษࡗࡓࡇ࡜ࡣゝࢃ࡞࠿ࡗࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊྠ᫬ᮇ࡟ཧຍࡉࢀࡓࠊࡇࡢࡓ
ࡧ࠾ஸࡃ࡞ࡾ࡟࡞ࡽࢀ࡚ࡋࡲ࠸ࡲࡋࡓࡅࢀ࡝ࡶࠊዉⰋඛ➃኱ࡢᓥᮏඛ⏕࡞࡝ࡣ࡞࠿࡞࠿ᛮ࠸
ษࡗࡓࡈពぢࢆฟࡋ࡚࠾ࡽࢀࡲࡋࡓࠋࡑ࠺࠸࠺ᙧ࡛ࠊ࡝࠺ࡋ࡚ࡶ⤌⧊ࡢ୰࡛ࡲ࡜ࡲࡗ࡚⪃࠼࡚࠸ࡿ࡜Ẽࡀ௜࠿࡞࠸࡜ࡇࢁ࡞࡝ࢆࡥࡗ࡜ᣦ᦬ࡋ࡚࠸ࡓࡔࡅࢀࡤࠊࡲࡓࡇࡕࡽࡶ⪃࠼┤ࡍࡇ࡜ࡀ࡛ࡁ࡚㠀ᖖ࡟࠸࠸ᶵ఍࡟࡞ࡿ࡜࠸࠺⤒㦂ࢆ࠸ࡓࡋࡲࡋࡓࠋ ᮏ᪥ࡢࡇࡕࡽഃࡢฟᖍ⪅ࢆࡈ⤂௓࠸ࡓࡋࡲࡍࠋᕥࡢ᪉࠿ࡽࠊ ᖺᗘࠊ௒ᖺᗘࡢ➨㸱◊✲୺ᖿ࡛ࠊホ౯ࢆᢸᙜࡋ࡚࠸ࡿྜྷ⏣ඛ⏕࡛ࡍࠋ㸦ྜྷ⏣㸧 ࡼࢁࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑࢀ࠿ࡽࠊ ᖺᗘࠊ ᖺᗘ࡜⥆ࡅ࡚⥲ົࢆᢸᙜࡋ࡚࠾ࡾࡲࡍ➨㸯◊✲୺ᖿࡢ㔝⏣ඛ⏕࡛ࡍࠋ
㸦㔝⏣㸧 㔝⏣࡛ࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ྠࡌࡃ  ᖺᗘࠊ ᖺᗘࡢ◊✲୺ᖿ࡛ࠊ᫖ᖺᗘࡣ➨㸳࡛᪋タ㐠Ⴀࢆᢸᙜࡋ࡚࠸ࡲ
ࡋࡓࡅࢀ࡝ࡶࠊ௒ᖺᗘࡣ➨㸰ࡢ㈈ົࢆᢸᙜࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍᑠᯘඛ⏕࡛ࡍࠋ㸦ᑠᯘ㸧 ᑠᯘ࡛ࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑࢀ࠿ࡽࠊࡸࡣࡾ᫖ᖺᗘࠊ௒ᖺᗘ࡜⥆ࡅ࡚➨㸲◊✲୺ᖿ࡜ࡋ࡚Ᏻ඲⾨⏕࣭▱㈈࣭
ᆅᇦ㐃ᦠࢆᢸᙜࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍ஭ཱྀඛ⏕࡛ࡍࠋ㸦஭ཱྀ㸧 ஭ཱྀ࡛ࡍࠋࡼࢁࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑࢀ࠿ࡽࠊࡇࡢ㸱᭶࡛ᩍᤵࡣᐃᖺ㏥⫋ࡉࢀࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊᘬࡁ⥆ࡁ URA ࡜ࡋ࡚ᇶ⏕◊ࡢࡓࡵ࡟㡹ᙇࡗ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍすᮧඛ⏕࡛ࡍࠋ㸦すᮧ㸧 すᮧ࡛ࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
− 46 −

㸦ᒣᮏ㸧 ௒᪥ࡣすᮧඛ⏕࡟ྖ఍ᙺࢆ࠾㢪࠸ࡋ࡚࠾ࡾࡲࡍࠋ ࡇࢀ࠿ࡽࠊእ㒊ࡢඛ⏕᪉ࢆ⚾࠿ࡽ⡆༢࡟ࡈ⤂௓ࡋ࡚ࠊࡑࡢᚋࠊᑡࡋࡎࡘࡈ⮬ศ࡛ఱ࠿࠾ヰࡋ࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜࡟ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋእ㒊ࡢඛ⏕᪉࡜ࡋࡲࡋ࡚ࡣࠊᇶ⏕◊࡟ࡣ㐠Ⴀ఍㆟࡜࠸࠺ࡶࡢࡀ࠶ࡾࡲࡋ࡚ࠊࡑࡇࡢጤဨࡢ᪉࠿ࡽఱྡ࠿ࠊࡑࢀ࠿ࡽࠊࡑ࠺࡛ࡣ࡞࠸᪉࠿ࡽఱ
ྡ࠿࡜࠸࠺ᙧ࡛࠸ࡘࡶ⤌⧊ࡉࡏ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍࠋ௒ᅇ࡟㛵ࡋ࡚ࡣ⌧ᅾࡢ㐠Ⴀ఍㆟ࡢጤဨ࡛࠶ࡾࡲࡍኴ⏣ඛ⏕࡜᳃ඛ⏕࡟ࡈཧຍ࠸ࡓࡔࡁࡲࡋࡓࠋࡲࡓࠊ๓ᮇࡢ㐠Ⴀ఍㆟ጤဨ࡛࠶ࡽࢀࡓሷぢඛ⏕࡟ࡶ࠾㢪࠸࠸ࡓࡋࡲࡋࡓࠋ ḟ࡟ࠊ㐠Ⴀ఍㆟࡜ࡣ┤᥋㛵ಀ࡞࠸ඛ⏕᪉࡛ࡍࡅࢀ࡝ࡶࠊࡇࡢ㸱᭶ᮎࡲ࡛㜰኱ࡢ⺮ⓑ◊ࡢᡤ㛗ࢆࡉࢀ࡚࠸ࡲࡋࡓ㛗㇂ඛ⏕࡟࠾㢪࠸ࡋࡲࡋࡓࠋ⺮ⓑ◊ࡣ኱Ꮫ௜⨨࡛ࡍࡅࢀ࡝ࡶࠊ኱Ꮫࡢඹ
ྠ฼⏝ᣐⅬ࡜࠸࠺ࡇ࡜࡛ࠊࢃࢀࢃࢀ࡜࠸ࢁ࠸ࢁ࡞ၥ㢟ࢆඹ᭷ࡋ࡚࠸ࡿ࡜ࡇࢁࡶ࠶ࡾࡲࡍࡢ࡛ࠊ
ࡑ࠺࠸࠺ほⅬ࠿ࡽࡢࡈពぢࡀ㡬ࡅࡓࡽ࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ ࡑࢀ࠿ࡽࠊ㑇ఏ◊࠿ࡽⲨᮌඛ⏕࡟࠾㢪࠸࠸ࡓࡋࡲࡋࡓࠋⲨᮌඛ⏕ࡢ࡜ࡇࢁࡣ኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ࡣูࡢᶵᵓ࡟࡞ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊ⥲◊኱࡛⏕࿨⛉Ꮫᑓᨷ࡜࠸࠺ࡇ࡜࡛ࡈ୍⥴ࡋ࡚࠸ࡲࡋ࡚ࠊࡑ࠺࠸࠺๭ྜ㏆࠸࡜ࡇࢁ࠿ࡽぢ࡚࠸ࢁ࠸ࢁࡈពぢࡀ㡬ࡅࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮࡗ
࡚࠸ࡲࡍࡢ࡛ࠊࡼࢁࡋࡃ࠾㢪࠸ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋ ࡑࢀ࡛ࡣࠊࡑࢀࡒࢀࡢඛ⏕᪉ࠊࡶ࠺ᑡࡋ㊊ࡾ࡞࠸㒊ศࡢ⮬ᕫ⤂௓࡞ࡾࢆࠊኴ⏣ඛ⏕࠿ࡽࠋ㸦ኴ⏣㸧 ௒ᖺᗘ㐠Ⴀ఍㆟ጤဨ࡛ᇶ⏕◊࡟࠾ୡヰ࡟࡞ࡗ࡚࠾ࡾࡲࡍኴ⏣࡜⏦ࡋࡲࡍࠋศ㔝࡜ࡋ࡚ࡣ DNA ࡸࢡ࣐ࣟࢳࣥᵓ㐀ࡢࢲ࢖ࢼ࣑ࢡࢫ࡜࠿ࠊ࢚ࣆࢪ࢙ࢿࢸ࢕ࢡࢫࠊࣀࣥࢥ࣮ࢹ࢕ࣥ
ࢢ RNA ࡜࠸࠺࡜ࡇࢁࢆࡸࡗ࡚࠾ࡾࡲࡍࠋ ௒ࠊ⛉Ꮫ࡛ࡣฟཱྀᚿྥࡀ㠀ᖖ࡟ྉࡤࢀ࡚࠸࡚ࠊᛂ⏝ࠊᛂ⏝࡜࡞ࡗ࡚࠾ࡾࡲࡍࡅࢀ࡝ࡶࠊᇶ
♏⛉Ꮫࡀ㠀ᖖ࡟኱஦࡛࠶ࡿ࡜࠸࠺ࡇ࡜ࢆ⚾ࡣㄆ㆑ࡋ࡚࠾ࡾࡲࡋ࡚ࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡣࡑࡇࢆᢸࡗ࡚࠸ࡃ㠀ᖖ࡟኱஦࡞◊✲ᶵ㛵ࡔ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊ࡛ࡁࡿ㝈ࡾຊ࡟࡞ࡗ࡚ࠊ࠸ࢁ࠸ࢁ࡞
ຓゝ࡞࡝ࢆࡋ࡚ࡲ࠸ࡾࡓ࠸࡜ᛮ࠸ࡲࡍࠋ࡝࠺ࡒࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦᳃㸧 ྡྂᒇ኱Ꮫࡢ᳃㑳ᜨ࡛ࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ⚾ࡶ㐠Ⴀ఍㆟࡟㐣ཤᩘᖺࡎࡗ࡜࠾ୡヰ࡟࡞ࡗ࡚࠾ࡾࡲࡋ࡚ࠊ࠶ࡿ୍ᐃᮇ㛫୰࡟ఱᅇ࠿ࡇࡇ࡛࠸ࢁ࠸ࢁ࡞఍㆟࡟ฟᖍࡍࡿ
ࡇ࡜࡟ࡼࡗ࡚ࠊ࡝࠺࠸࠺ࡇ࡜ࡀ⾜ࢃࢀ࡚࠸ࡿ࠿࡜࠸࠺ࡇ࡜ࡣ࠶ࡿ⛬ᗘࡣᏑࡌୖࡆ࡚࠸ࡿࡘࡶ
ࡾ࡛ࡍࡀࠊホ౯࡜࠸࠺ࡇ࡜࡟㛵ࡋ࡚ࡣึࡵ࡚࡛ࡍࡢ࡛ࠊࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ ࠶࡜ࡣࠊࡇࡢ㛫ࠊዪᛶ PI ࡢࡇ࡜ࡶ࠶ࡾࡲࡋ࡚ࠊࡸࡣࡾ᪥ᮏ࡛࣮࣋ࢩࢵࢡࢧ࢖࢚ࣥࢫࡢ୰ᚰ
ࢆᢸ࠺ᇶ♏⏕≀Ꮫ◊✲ᡤ࡛ዪᛶ◊✲⪅ࡀ PI ࡜ࡋ࡚ά㌍࡛ࡁࡿሙᡤ࡛ࡶ࠶ࡗ࡚࡯ࡋ࠸࡞࡜࠸
࠺ࡇ࡜ࡶేࡏ࡚㢪ࡗ࡚࠾ࡾࡲࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ㸦ሷぢ㸧 ៞᠕⩏ሿ኱Ꮫࡢሷぢ࡛ࡍࠋᒸ⏣ඛ⏕ࡀᡤ㛗ࡢ࡜ࡁ࡟㐠Ⴀ఍㆟ጤဨࢆ㸰ᅇ࡛ࡋࡻ࠺
࠿ࠊົࡵࡉࡏ࡚ࡶࡽ࠸ࡲࡋࡓࠋ࡛ࡍ࠿ࡽࠊ᳃ࡉࢇࡀゝࢃࢀࡓࡼ࠺࡟ࠊ࠶ࡿ⛬ᗘࡇࡢ◊✲ᡤࡢࡇ࡜ࡣᢕᥱࡋ࡚࠸ࡿࡘࡶࡾ࡞ࡢ࡛ࡍࡀࠊホ౯࡜࠸࠺ほⅬ࠿ࡽࡣ࡝࠺࠸࠺ࡇ࡜ࢆゝࡗࡓࡽ࠸࠸
ࡢ࠿࡜࠸࠺ࡇ࡜ࢆᛮࡗ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊከศཝࡋ࠸ពぢࢆゝࡗࡓ᪉ࡀ࠸࠸ࡢ࡛ࡣ࡞࠸

− 47 −

࠿࡜ᛮࡗ࡚࠸ࡲࡍࡢ࡛ࠊ࡛ࡁࡿࡔࡅࡑ࠺࠸࠺ពぢࢆゝ࠾࠺࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡼࢁࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ
㸦㛗㇂㸧 ኱㜰኱Ꮫ⺮ⓑ㉁◊✲ᡤࡢ㛗㇂࡜⏦ࡋࡲࡍࠋᒣᮏඛ⏕࡟ࡈ⤂௓࠸ࡓࡔࡁࡲࡋࡓࡼ࠺
࡟ࠊࡇࡢ㸱᭶ࡲ࡛㸲ᖺ㛫ࠊᡤ㛗⫋ࢆົࡵࡉࡏ࡚࠸ࡓࡔࡁࡲࡋࡓࠋ኱Ꮫ௜⨨◊✲ᡤ࡜ࡋ࡚඲ᅜ
ࡢඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ࡜ࡋ࡚ᇶ⏕◊࡜኱ኚ㏆࠸஦ᴗࢆࡋ࡚࠾ࡾࡲࡍࠋࡑࢀ࠿ࡽࠊࡶࡕࢁ
ࢇ኱Ꮫࡢ୍ဨ࡜ࡋ࡚ࡢᙺ๭ࡶ࠶ࡿࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊ࠺ࡕࡢ◊✲ᡤࡣ๰タ௨᮶  ᩘᖺࠊඹྠ
฼⏝◊࡜ࡋ࡚ࡸࡗ࡚ࡁ࡚࠾ࡾࡲࡍࡢ࡛ࠊᇶ⏕◊ࡢ≉࡟࠸ࢁ࠸ࢁ࡞ඃࢀࡓ᪋タ➼ࢆά⏝ࡋࡓࢥ࣑ࣗࢽࢸ࢕࣮ࡢࡓࡵࡢάືࢆぢࡏ࡚࠸ࡓࡔࡁࡲࡋ࡚ࠊࡇࢀࡣࢃࢀࢃࢀ࡟࡜ࡗ࡚ࡶຮᙉࡉࡏ࡚
࠸ࡓࡔࡃⰋ࠸ᶵ఍ࡔ࡜ᛮ࠸ࡲࡍࠋ ホ౯࡜࠸࠺ࡢࡣ⤌⧊࡟࡜ࡗ࡚ࡣ኱ኚ㔜せ࡞ࡇ࡜࡛ࡍࡅࢀ࡝ࡶࠊ୍᪉ࠊ↮ࡓ࠸㒊ศࡶ࠶ࡗ࡚
㞴ࡋ࠸࡛ࡍࠋ≉࡟௒ࠊሷぢඛ⏕ࡀཝࡋ࠸ពぢࡶ࡜࠸࠺ࡇ࡜࡛ࠊࡑࢀࡣ኱ษ࡞ࡢ࡛ࡍࡀࠊពぢࢆ㡬࠸࡚ࠊࡑࢀࡀࡁࡕࢇ࡜ᨵၿࡉࢀࡿࠊ཯ᫎࡉࢀࡿ࡜࠸࠺ࡼ࠺࡞ྲྀࡾᢅ࠸ࡢ࡛ࡁࡿពぢࢆゝ࠺ࡇ࡜ࡀ኱ษ࡛࠶ࡾࡲࡍࠋ≉࡟᪥ᮏࡢホ౯ጤဨࡢ᪉ࡣࡑࢀࢆᚰᚓ࡚࠾ࡾࡲࡍࡅࢀ࡝ࡶࠊᾏእࡢホ౯ጤဨࡢඛ⏕᪉࡟ホ౯ࢆ㡬ࡃ࡜ࠊࡑࢀࡒࢀࡢඛ⏕᪉ࡢពぢࡀ㸯ᖺࠊ㸰ᖺᚋ࡟࡝࠺཯ᫎࡉ
ࢀࡓࡢ࠿࡜࠸࠺ࣇ࢕࣮ࢻࣂࢵࢡࢆࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸࡜࠸࠺≧ἣ࡟ࡶ࡞ࡾࡲࡋ࡚ࠊホ౯ࡉࢀࡗᨺࡋ࡜࠸࠺ࡇ࡜࡛ࡣチࡉࢀ࡞࠸᫬௦࡟ධࡗ࡚ࡁࡓ࡜ᛮ࠸ࡲࡍࠋ⚾ࡶཬࡤࡎ࡞ࡀࡽࠊྍ⬟࡞ࣞ࣋ࣝ࡜ゝࡗࡓࡽㄒᘢࡀ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺ཝࡋ࠸ពぢࢆゝ࠺ࡼ࠺࡟ດຊࡉࡏ࡚࠸
ࡓࡔࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍࠋ
㸦Ⲩᮌ㸧 㑇ఏ◊ࡢⲨᮌ࡛ࡍࠋ኱Ꮫඹྠ฼⏝ᶵ㛵࡜࠸࠺❧ሙ࡛࠸ࡘࡶぢࡉࡏ࡚࠸ࡓࡔ࠸࡚࠸
ࡿࡢ࡛ࡍࡀࠊ௒ᅇࡣ๭࡜ࡁࡗࡕࡾ࡜ㄞࡲࡏ࡚࠸ࡓࡔ࠸ࡓࡢ࡛ࠊࡑࢀ࡞ࡾࡢពぢࢆゝࢃࡏ࡚࠸ࡓࡔࡅࢀࡤ࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ㈨ᩱ㸲࡟ࡇࢀࡲ࡛ࡢᩘᖺࡢホ౯఍㆟࡛ࡢᣦ᦬࡟
ᑐࡋ࡚࡝ࡢࡼ࠺࡟ᑐᛂࡋࡓ࠿࡜࠸࠺ࡇ࡜ࢆࡲ࡜ࡵ࡚࠾ࡾࡲࡍࠋࡇࡇ࡛ࡈᣦ᦬ࡉࢀࡓⅬ࡟ᑐᛂࡋ࡚௒ᚋࡢᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㐠Ⴀ࡟཯ᫎࡉࡏ࡚࠸ࡃ࡜࠸࠺ࡇ࡜࡛ࠊ㠀ᖖ࡟㔜せ࡞఍㆟࡜ㄆ㆑ࡋ࡚࠾ࡾࡲࡍࡢ࡛ࠊࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ ࡑࢀ࡛ࡣࠊ᭱ึ࡟ᇶ⏕◊ࡢᴫせ࡟ࡘ࠸࡚ᒣᮏඛ⏕ࡢ᪉࠿ࡽ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦ᒣᮏ㸧 ࡣ࠸ࠋࡏࡗ࠿ࡃ㸳ேࡢඛ⏕᪉࡟㈗㔜࡞᫬㛫ࢆ౑ࡗ࡚࠸ࡓࡔ࠸࡚㞟ࡲࡗ࡚࠸ࡓࡔ࠸
࡚࠸ࡲࡍࡢ࡛ࠊ㡬࠸ࡓࡈពぢ࡟ἢࡗ࡚ᇶ⏕◊ࡢ௒ᚋࡢ㐠Ⴀࡀᨵၿࡉࢀࡿࡼ࠺࡟ດຊࡋ࡚࠸ࡁ
ࡓ࠸࡜ᛮࡗ࡚࠾ࡾࡲࡍࡢ࡛ࠊࡼࢁࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ㸯 ᖹᡂ  ᖺᗘᐇ⦼ࡢᴫせ㸦ᒣᮏ㸧 ࡑࢀ࡛ࡣࠊ㈨ᩱ㸱ࢆ౑ࡗ࡚ᇶ⏕◊ࡢᴫせࢆࡈㄝ᫂࠸ࡓࡋࡲࡍࠋ᪤࡟ࡈᢎ▱ࡢࡇ࡜ࡀከ࠸࠿࡜ᛮ࠺ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡊࡗ࡜ࡈㄝ᫂࠸ࡓࡋࡲࡋ࡚ࠊࡉࡽ࡟㋃ࡳ㎸ࢇࡔㄽⅬ࡟ࡘ࠸− 48 −

࡚ࡣ㛵ಀࡢ୺ᖿࡢ᪉࠿ࡽࡈㄝ᫂ࡍࡿ࡜࠸࠺ᙧ࡟ࡉࡏ࡚࠸ࡓࡔࡁࡓ࠸࡜ᛮࡗ࡚࠸ࡲࡍࠋ

㸦㈨ᩱ㸱3㸧ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ࣑ࢵࢩࣙࣥ࡜ࡋ࡚኱ࡁࡃ஧ࡘ࠶ࡿ࡜⪃࠼࡚࠾ࡾࡲࡍࠋ
୍ࡘࡣࠊ㧗ᗘ࡞⏕≀Ꮫࡢ◊✲ࢆ⾜࠺࡜࠸࠺ࡇ࡜ࠋࡶ࠺୍ࡘࡣ᪂◊✲㡿ᇦࢆ㛤ᣅࡋ࡚ࠊᅜ㝿ⓗ࡞Ⓨᒎࢆ≌ᘬࡍࡿࡇ࡜࡟ࡼࡗ࡚ᣦᑟⓗ❧ሙࢆ☜ಖࡋࡘࡘࠊᅜෆእࡢ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮࡟
ඹྠ◊✲ࡢሙࢆᥦ౪ࡋ࡚ඛ➃◊✲ࢆ᥎㐍ࡍࡿ࡜࠸࠺኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ࡢ࣑ࢵࢩࣙࣥ࡜
࠸࠺ࡶࡢࠋࡇࡢ஧ࡘࢆేࡏ࡚⾜ࡗ࡚࠸࠿࡞࠸࡜࠸ࡅ࡞࠸࡜࠸࠺⤌⧊࡛࠶ࡿ࡜ㄆ㆑ࡋ࡚࠾ࡾࡲ
ࡍࠋ ࡑࡢୗ࡟ࡣᇶ⏕◊࡛ᮦᩱ࡜ࡋ࡚ᢅࡗ࡚࠸ࡿ࠸ࢁ࠸ࢁ࡞⏕≀ࢆᅗ᱌໬ࡋ࡚♧ࡋ࡚࠸ࡲࡍࠋ
ࡇࢀࡣ⨁ࣂࢵࢪ࡟࡞ࡗ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊ࣮࢜ࣉࣥ࢟ࣕࣥࣃࢫ࡞࡝࡛㓄ࡿ࡜Ꮚ࡝ࡶࡓࡕ
࡟ࡣ㠀ᖖ࡟ேẼࡀ࠶ࡾࡲࡍࠋ

㸦3㸧ᇶ⏕◊ࡢἢ㠉࡛ࡍࠋᇶ⏕◊ࡣ᪥ᮏᏛ⾡఍㆟ࡀࡲࡔ◊✲ᡤࡢタ❧ࡢ່࿌ᶒ࡞࡝ࢆ⾜౑࡛ࡁࡓ᫬௦࡟ࠊᏛ⾡఍㆟ࡢ່࿌࡟ࡼࡗ࡚࡛ࡁࡲࡋࡓࠋึ௦ࡢ᱓ཎඛ⏕ࡀ╔௵ࡉࢀ࡚࠿ࡽ ᖺࡀࡓࡗࡓ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࠋ ࡇࢀࡶᚋ࡛ࡈㄝ᫂ࡀ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊ ᖺ࡟኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡ
ࢺࡀጞࡲࡾࠊ ᖺ  ᭶࡟ࡣ◊✲ຊᙉ໬ᡓ␎ᐊ࡜࠸࠺ࡶࡢࡀタ⨨ࡉࢀࡲࡋࡓࠋࡇࢀࡣ⮬↛⛉Ꮫ◊✲ᶵᵓࡀ URA ࢩࢫࢸ࣒ࢆྲྀࡾධࢀࡿ࡜࠸࠺ண⟬ᥐ⨨ࢆཷࡅ࡚ືࡁฟࡋࡓࡇ࡜ࢆ཯ᫎ
ࡋ࡚ࠊࡑࢀࡲ࡛࠶ࡗࡓᗈሗᐊࡸᅜ㝿㐃ᦠᐊ࡞࡝ࢆ୍ࡘࡢ⤌⧊࡟ࡲ࡜ࡵ࡚◊✲ຊᙉ໬ᡓ␎ᐊࢆタ⨨ࡋ࡚࠾ࡾࡲࡍࠋࡲࡓࠊ௒ᖺࡢ㸱᭶࠿ࡽࡣ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮࡜࠸࠺ࡶࡢࡀ᪂つ࡟ືࡁฟࡋࡲࡋࡓࠋ

㸦3㸧⤌⧊ᙧែ࡛ࡍࠋᡤ㛗࠿ࡽྑࡢ᪉࡟◊✲㡿ᇦࡀࡎࡗ࡜᭩࠸࡚࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊࡑࡢ
㛫࡟ඛ⏕᪉࡟ࡶධࡗ࡚࠸ࡓࡔ࠸࡚࠸ࡿ㐠Ⴀ఍㆟ࡀ࠶ࡾࡲࡍࠋࡑࢀ࠿ࡽࠊ◊✲ᡤ㛗࡟ࡪࡽୗࡀ
ࡿᙧ࡛ࠊ௒⏦ࡋୖࡆࡓ URA ࢆ୰ᚰ࡜ࡋࡓ⤌⧊࡛࠶ࡿ◊✲ຊᙉ໬ᡓ␎ᐊ࡜࠸࠺ࡶࡢࡀ᪂ࡓ࡟タ⨨ࡉࢀ࡚࠾ࡾࡲࡍࠋ

㸦3㸧◊✲⤌⧊࡛ࡍࠋ⣽⬊⏕≀ᏛࠊⓎ⏕⏕≀Ꮫࠊ⚄⤒⏕≀Ꮫࠊ㐍໬ከᵝᛶ⏕≀Ꮫࠊ⎔ቃ⏕≀Ꮫࠊ⌮ㄽ⏕≀Ꮫࠊ࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫ◊✲㡿ᇦ࡜࠸࠺ࡼ࠺࡞ศ㔝ࡀ࠶ࡾࡲࡍࠋࡑࢀ࠿
ࡽࠊࢭࣥࢱ࣮࡜ࡋ࡚⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ࠊ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮࡜࠸࠺ࡶࡢࡀ࠶ࡗ
࡚ࠊࡇࡇ࡟♧ࡉࢀ࡚࠸ࡿࡼ࠺࡞ேဨࡀ㓄⨨ࡉࢀ࡚࠸ࡲࡍࠋ ⣽⬊⏕≀Ꮫࡣすᮧඛ⏕ࡀᐃᖺ࡛㏥⫋ࡉࢀࡓࡢ࡜ࠊᯇᯘඛ⏕ࡀྡྂᒇ኱Ꮫ࡟⛣ࡽࢀࡓࡢ࡛ࠊ
ࡇࡇࡣࡕࡻࡗ࡜ᡭⷧ࡟࡞ࡗ࡚࠾ࡾࡲࡍࠋ࠾࠸࠾࠸ே஦ࢆ㐍ࡵ࡚ࠊ◊✲ຊࡣపୗࡋ࡞࠸ࡼ࠺࡟
㓄៖ࡋ࡚࠸ࡁࡓ࠸࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ

㸦3㸧ᇶ⏕◊ࡢ㈈ᨻ≧ἣ࡛ࡍࠋᇶ⏕◊ࡢ㈈ᨻࡢ୍ࡘࡢ≉ᚩࡣ⛉◊㈝ࡀẚ㍑ⓗከ࠸࡜࠸࠺ࡇ
࡜࡛ࡍࠋᒸᓮ㸱ᶵ㛵ࡣศᏊ◊ࠊ⏕⌮◊ࠊᇶ⏕◊࡜࠶ࡾࠊつᶍⓗ࡟ࡣᇶ⏕◊ࡀ୍␒ᑠࡉ࠸ᙧ࡟
࡞ࡿ࡜ᛮ࠺ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ⛉◊㈝ࡢ⋓ᚓ㢠࡛ࡣ୍␒ከ࠸࡜࠸࠺ࡼ࠺࡞≧ἣ࡛ࡍࠋࡓࡔࠊཷ

− 49 −ク◊✲࡞࡝ࢆేࡏࡿ࡜ࠊࡑࡕࡽࡢ᪉㠃࡛ࡣࡑࢀ࡯࡝ᙉࡃ࡞࠸࡜࠸࠺⌧ᐇࡶ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊ
බⓗእ㒊㈨㔠ࢆᑟධࡍࡿ࡜࠸࠺ព࿡࡛ࡣ࠿࡞ࡾ㡹ᙇࡗ࡚ࡁ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡣゝ࠼ࡿ࡜ᛮ࠸
ࡲࡍࠋ㸦3㸧ᇶ⏕◊ࡢάືࢆ஬ࡘࡄࡽ࠸࡟ศࡅ࡚⪃࠼࡚࠾ࡾࡲࡍࠋ᫬ィ࡛ゝ࠺࡜㸵᫬ࡄࡽ࠸ࡢ࡜
ࡇࢁ࡟ࠊձࡀ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊ
ࠕ◊ࠖ࡜᭩࠸࡚࠶ࡿᏛ⾡◊✲ࡢ᥎㐍࡜࠸࠺ࡇ࡜࡛ࡍࠋղࡣ
ࠕඹ࡛ࠖࠊඹྠ฼⏝࣭ඹྠ◊✲ࡢ᥎㐍࡛ࡍࠋࡇࡢ஧ࡘࡣ᭱ึ࡟⏦ࡋୖࡆࡓ஧ࡘࡢ኱ࡁ࡞࣑ࢵ
ࢩࣙࣥ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࠋճࡣࠕᦠࠖ࡜࠸࠺ࡇ࡜࡛ࠊᅜ㝿㐃ᦠࠊᗈሗάືࡢᒎ㛤࡜࠸࠺ࡇ࡜࡛ࡍࠋմࡣࠕ᪂࡛ࠖࠊ᪂㡿ᇦࡢ㛤ᣅ࡜࠸࠺ࡇ࡜࡛ࡍࠋࡇࡇ࡟ࡣ࠸ࢁ࠸ࢁ࡞㡯┠ࡀᣲࡆ࡚࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊࡇࢀࡶࡲࡓᚋ࡛ᚲせࡀ࠶ࢀࡤࡶ࠺ᑡࡋヲࡋࡃࡈㄝ᫂⏦ࡋୖࡆࡿࡼ࠺࡟ࡋ
ࡓ࠸࡜ᛮ࠸ࡲࡍࠋࡑࢀ࠿ࡽࠊյࡣࠕⱝࠖ࡜᭩࠸࡚࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊⱝᡭ◊✲⪅ࡢ⫱ᡂ࡜࠸࠺ࡇ࡜࡛ࡍࠋ௨ୖࡢ஬ࡘࡄࡽ࠸࡟ศࡅ࡚ࠊ࠸ࢁ࠸ࢁ⪃࠼ࡓࡾࠊ㆟ㄽࡋࡓࡾࡋ࡚࠸ࡿ࡜࠸࠺≧ἣ࡛ࡍࠋ㸦3㸧ࡇࡇࡣࠊ◊✲ຊ࡟ࡘ࠸࡚ࠊᇶ⏕◊ࡀㄽᩥᘬ⏝ᗘᣦᩘ࡞࡝࡛࡝ࡢࡼ࠺࡟ホ౯ࡉࢀ࡚࠸
ࡿ࠿࡜࠸࠺ࡇ࡜ࢆ♧ࡋࡓࡶࡢ࡛ࡍࠋ

㸦3㸧ㄽᩥⓎ⾲࡛ࡍࠋࡇࢀࡶ࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ࡀ㧗࠸Ꮫ⾡ㄅ࡟ฟࡍࡇ࡜ࡔࡅࡀ࠸࠸ࡢ
࠿࡜࠸࠺㆟ㄽࡶ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊࡸࡣࡾࡇ࠺࠸࠺࡜ࡇࢁ࡟ฟ࡚࠸ࡿ࡜ࡑࢀ࡞ࡾ࡟ホ౯ࡉࢀࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡶ࠶ࡿࢃࡅ࡛ࡍࠋ⌧≧࡜ࡋ࡚ࡣࡇࡢ⾲ࡢࡼ࠺࡟࡞ࡗ࡚࠸ࡲࡍࠋၥ㢟࡟ࡍ࡭ࡁ࡛ࡣ࡞࠸࠿ࡶࡋࢀࡲࡏࢇࡀࠊୖࡢ᪉ࡀᑡࡋ✵࠸࡚࠸࡚ࠊࡶ࠺ࡕࡻࡗ࡜ᇙࡲࡗ࡚࠸ࢀࡤ࠸
࠸࡞࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡶ࠶ࡾࡲࡍࠋࣀ࣮࣋ࣝ㈹ࢆࡶࡽࡗࡓࣛࣥࢹ࢕࣭ࢩ࢙ࢵࢡ࣐ࣥࡣࠕNatureࠖࡸࠕCellࠖࡸࠕScienceࠖ࡟ࡣㄽᩥࢆฟࡉ࡞࠸ࠊ࡜ゝࡗ࡚࠸ࡲࡍࠋ㈹ࢆࡶࡽࡗ࡚ࡋࡲ࠺࡜ゝ࠼ࡿ࠿ࡶࡋࢀࡲࡏࢇࡅࢀ࡝ࡶࠊࢃࢀࢃࢀ࡜ࡋ࡚ࡣ࡞࠿࡞࠿ࡑࡇࡲ࡛ゝ࠺⮬ಙࡣ࡞࠸ࡢ࡛ࠊࡇ࠺
࠸࠺⾲ࢆᶓ┠࡛࡟ࡽࡳ࡞ࡀࡽ㡹ᙇࡗ࡚࠸ࡁࡓ࠸࡜ᛮࡗ࡚࠸ࡲࡍࠋ

㸦3㸧ḟࡣ⛉◊㈝࡛ࡍࠋඛ࡯࡝⏦ࡋୖࡆࡲࡋࡓࡼ࠺࡟⛉◊㈝࡜ࡋ࡚ࡣࠊ≉࡟ྑഃ࡟࠶ࡾࡲ
ࡍࡼ࠺࡟㸯௳ᙜࡓࡾࡢ㔠㢠ࡀ኱ࡁ࠸࡜࠸࠺ࡢࡀ୍ࡘࡢ≉ᚩ࡛ࡍࠋẚ㍑ⓗ࡞኱ࡁ࡞⛉◊㈝ࢆ㡬࠸࡚࠸ࡲࡍࠋ

㸦3㸧ࡑࡢෆᐜ࡛ࡍࡅࢀ࡝ࡶࠊ᪂Ꮫ⾡㡿ᇦ◊✲࡞࡝࡛ࡣ࠿࡞ࡾᇶ⏕◊ࡀᏑᅾឤࢆ♧ࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡀゝ࠼ࡿ࠿࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ

㸦3㸧ࡑࢀ࠿ࡽࠊ᭱㏆ࡢ◊✲ᡂᯝ࡛ࡍࠋࡇࢀ࡟ࡘ࠸࡚ࡣᚋ࡛ࡲࡓලయⓗ࡟ᑡࡋㄝ᫂ࡀ࠶
ࡿ࠿ࡶࡋࢀࡲࡏࢇࡢ࡛ࠊ⚾࠿ࡽࡣ┬࠿ࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ

㸦3㸧ඹྠ฼⏝◊✲ࡢᩘࡢ᥎⛣࡛ࡍࠋࡇࢀࡶࡲࡓᚲせࡀ࠶ࢀࡤᚋ࡛㔝⏣୺ᖿ࠿ࡽ㏣ຍㄝ
᫂ࡀ࠶ࡿ࠿ࡶࡋࢀࡲࡏࢇࠋ኱యࢥࣥࢫࢱࣥࢺ࡟  ࡄࡽ࠸ࡢඹྠ฼⏝◊✲ࡀ᥎⛣ࡋ࡚࠸ࡿ࡜
࠸࠺ᙧ࡟࡞ࡗ࡚࠸ࡲࡍࠋ
− 50 −

㸦3㸧ඹྠ฼⏝◊✲ࢆ᥎㐍ࡍࡿࡓࡵ࡟ࢭࣥࢱ࣮ᶵ⬟ࢆᙉ໬ࡋ࡚࠸ࡿ࡜࠸࠺⌧≧ࡀ࠶ࡾࡲࡍࠋ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮࡛ࡣḟୡ௦ࢩ࣮ࢣࣥࢧ࣮࡟ࡼࡿ㓄ิỴᐃ࡜ࡑࡢᚋࡢゎᯒࢆඹྠ◊✲࡛⾜࠺࡜࠸࠺ࡇ࡜࡛ࠊࡇࡇࡣ㔜ಙ≉௵෸ᩍᤵࡀ㡹ᙇࡗ࡚ࡃࢀ࡚࠸ࡲࡋ࡚ࠊ඲ᅜⓗ࡞ඹྠ◊✲ࡀ㐍⾜ࡋ࡚࠸ࡲࡍࠋࡇࡢࢭࣥࢱ࣮࡟ࡣ௚࡟ගᏛゎᯒᐊࠊ᝟ሗ⟶⌮ゎᯒᐊࡀ࠶ࡾࡲࡍࠋྑഃ
࡟ࡣࣔࢹࣝ⏕≀◊✲ࢭࣥࢱ࣮ࡀ♧ࡉࢀ࡚࠸ࡲࡍࠋࡇࡇ࡛ࡣࣂ࢖࢜ࣜࢯ࣮ࢫࡢ㛵ಀࡶᘬࡁཷࡅ
࡚࠾ࡾࡲࡍࠋ≉࡟࣓ࢲ࢝ࡀ୰ᚰ࡛ࡍࡅࢀ࡝ࡶࠊ࢔ࢧ࢞࢜ࢆࡶᢅࡗ࡚࠸ࡲࡍࠋ࣓ࢲ࢝࡞࡝ࡣᅜ
እ࠿ࡽࡶ࠿࡞ࡾㄳồࡀ᮶࡚ᥦ౪ࡋ࡚࠸ࡿ࡜࠸࠺ᐇ᝟ࡀ࠶ࡾࡲࡍࠋ

㸦3㸧࣓ࢲ࢝ࣂ࢖࢜ࣜࢯ࣮ࢫࡢヲ⣽ࢆ⤂௓ࡋ࡚࠸ࡲࡍࠋ

㸦3㸧ḟࡢ࣮࣌ࢪࡣ࢔ࢧ࢞࢜ࡢࡇ࡜ࡀ᭩࠸࡚࠶ࡾࡲࡍࠋ

㸦3㸧ࡑࢀ࠿ࡽࠊ᳜≀⛉Ꮫࡢ᭱ඛ➃◊✲ᣐⅬ࡛ࡍࠋ㸦3㸧ᮾ᪥ᮏ኱㟈⅏௨㝆ࠊ㈗㔜࡞◊✲ヨᩱࡀ⅏ᐖ࡛ኻࢃࢀ࡚ࡋࡲ࠺ࡇ࡜ࡀၥ㢟࡟࡞ࡗ࡚
ࡁ࡚ࠊ㈗㔜࡞⏕≀ヨᩱࢆ࣮࢟ࣉࡋ࡚࠾ࡃࢭࣥࢱ࣮ࡀᚲせ࡛࠶ࡿ࡜࠸࠺ࡇ࡜࡟࡞ࡾࠊᇶ⏕◊ࡀ୰ᚰ࡟࡞ࡗ࡚඲ᅜࡢ኱Ꮫ࡜ࢱ࢖࢔ࢵࣉࡋ࡚ࠊIBBP㸦኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡ
ࢺ㸧ࢭࣥࢱ࣮࡜࠸࠺ࡶࡢࢆ⌧ᅾ㐠Ⴀࡋ࡚࠾ࡾࡲࡍࠋ

㸦3㸧ࡇࢀࡲ࡛࡟ IBBP ࢭࣥࢱ࣮࡟࡝ࢀࡄࡽ࠸ࡢᩘࡢࢧࣥࣉࣝࡀᐤクࡉࢀ࡚࠸ࡿ࠿࡜࠸
࠺ࡇ࡜࡛ࡍࠋᑠࡉ࠸ࢧࣥࣉࣝ࠿ࡽྜィࡍࡿ࡜  ୓ࡄࡽ࠸㞟ࡲࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲ
ࡍࠋ㸦3㸧኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࡣ≀ࢆಖᏑࡍࡿ࡜࠸࠺ࢫࢱࢸ࢕ࢵࢡ࡞
௵ົࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ᪂ࡋ࠸ಖᏑᢏ⾡ࡶ㛤Ⓨࡋࡼ࠺࡜࠸࠺ࡇ࡜࡛ࠊ඲ᅜ࠿ࡽࣉࣟࢪ࢙ࢡࢺࢆ
ເ㞟ࡋࡲࡋࡓࠋࡑ࠺࠸࠺ࣉࣟࢪ࢙ࢡࢺ࡟ᑐࡋ࡚ఱࡀࡋ࠿ࡢ◊✲㈝ࢆࢧ࣏࣮ࢺࡍࡿ࡜࠸࠺஦ᴗ
ࡶ⾜ࡗ࡚࠾ࡾࡲࡍࠋ

− 51 −

㸦3㸧㐃ᦠ஦ᴗࡢ㛵ಀ࡛ࡍࠋ⌧ᅾᾏእ࡜ࡣࠊࣁ࢖ࢹࣝ࣋ࣝࢢ࡟࠶ࡿ EMBL ࡜༠ᐃࢆ⤖ࢇ࡛࠾ࡾࡲࡍࠋࡇࢀࡣᇶ⏕◊ࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ࡜ࡋ࡚༠ᐃࢆ⤖ࢇ࡛࠸ࡿࡢ࡛
ࡍࡅࢀ࡝ࡶࠊ
ඹྠ࡛఍㆟ࢆ㛤ദࡋࡓࡾࠊ
ேᮦ஺ὶࢆ⾜ࡗࡓࡾࡋ࡚࠸ࡿ࡜࠸࠺≧ἣࡀ࠶ࡾࡲࡍࠋ
EMBL ࡟ࡘ࠸࡚ࡣ᮶ᖺ࡟༠ᐃࡀᨵᐃ࡟࡞ࡾࡲࡍࡢ࡛ࠊࡑࡢ๓ẁ㝵ࡢ‽ഛ࡜ࠊURA 㛵ಀࡢ௵ົࡢ┦ㄯࡀ࠶ࡾࡲࡋ࡚ࠊ௒㐌ᮎ࠿ࡽ⚾ࡣ EMBL ࡟ฟ࠿ࡅ࡚ᡤ㛗࡜࠾ヰࢆࡍࡿ࡜࠸࠺ணᐃ࡟࡞ࡗ
࡚࠸ࡲࡍࠋ ࡑࢀ࠿ࡽࠊ࣐ࢵࢡࢫࣉࣛࣥࢡ᳜≀⫱✀Ꮫ◊✲ᡤ࡜ࡶ༠ᐃࢆ⤖ࢇ࡛࠾ࡾࡲࡋࡓࡀࠊࡇࢀࡣࡇ
ࡢ㸱᭶ᮎ࡛ᮇ㝈࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡋࡓࠋࡇࡢ࡜ࡇࢁ᳜≀㛵ಀࡢඛ⏕᪉ࡀ⛣ࡽࢀࡓࡾࠊすᮧඛ⏕ࡀ㏥⫋ࡉࢀࡓࡾ࡜࠸࠺ࡼ࠺࡞ࡇ࡜࡛ࠊࡇࢀࡲ࡛࡝࠾ࡾࡢ༠ᐃࢆ⤖ࡪࡢࡣᑡࡋ↓⌮࠿࡞࡜࠸࠺≧ἣ࡛ࡍࡅࢀ࡝ࡶࠊ௒ᚋࡶ࠸ࢁ࠸ࢁ࡞◊✲఍ࢆඹ㏻࡛⾜࠺࡜࠸࠺ࡼ࠺࡞ᙧ࡛௒⌧ᅾヰࢆ㐍ࡵ࡚࠸ࡿ࡜ࡇࢁ࡛ࡍࠋ ࡇࢀࡶᚋ࡛ฟࡿ࡜ᛮ࠸ࡲࡍࡅࢀ࡝ࡶࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡜࠸࠺ࡶࡢࢆ⾜ࡗ࡚࠾ࡾࡲࡍࠋ
ࡉࡽ࡟᪂ศ㔝ࡢ㛤ᣅࢆ┠ᣦࡍࠊOBC ࡜࠸࠺⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ࡜࠸࠺ࡶࡢࡶタᐃࡋ࡚ࡁࡓ࡜ࡇࢁ࡛ࡍࠋࡓࡔࠊࡇࢀࡣࡇࢀࡲ࡛⥆ࡅ࡚ࡁ࡚ࠊ࠶ࡿ⛬ᗘᙧࡀᐃࡲࡗ࡚ࡁ࡚ࡋࡲࡗ
࡚࠸ࡿ࡜࠸࠺ᘢᐖࡶከᑡ࠶ࡿ࡜࠸࠺ࡇ࡜࡛ࠊ⌧ᅾࡣᾏእ࡜ࡢ㐃ᦠ࡟ࡘ࠸࡚ࠊࡶ࠺ᑡࡋ࣎ࢺ࣒
࢔ࢵࣉⓗ࡞ྲྀࡾ⤌ࡳࢆᙉࡵࡼ࠺࡜࠸࠺௒ᖺᗘࡢ᪉㔪ࢆ❧࡚࡚࠾ࡾࡲࡍࠋ

㸦3㸧(0%/ ࡜ࡢ༠ᐃࡢ୍⎔࡛ࠊDSLM ࡜࠸࠺ගࢩ࣮ࢺᆺ㢧ᚤ㙾ࡢά⏝࡜ᨵⰋࢆ㐍ࡵ࡚࠸ࡲࡍࠋ
㸦3㸧ࡇࢀࡲ࡛⾜ࡗ࡚ࡁࡓᅜ㝿఍㆟ࠊ࠶ࡿ࠸ࡣᐇ⩦ࢥ࣮ࢫ➼ࡢ㛤ദ≧ἣࡀࡲ࡜ࡵ࡚࠶
ࡾࡲࡍࠋ㸦3㸧ᴫ⟬せồ࡟࠾ࡅࡿ᪉㔪࡛ࠊࠕࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖ࡜࠸࠺ࡶࡢࢆ❧࡚࡚࠸ࡲࡍࠋࡇࢀࡣᏛ⾡఍㆟࡛㑅ᐃࡋ࡚࠸ࡓ኱ᆺࣉࣟࢪ࢙ࢡ
ࢺ࡟ࡶࠊ㑇ఏ◊࡜ヰࡋ࠶ࡗ࡚ࠊ㑇ఏ◊࡜ᇶ⏕◊ࡀ୰ᚰ࡟࡞ࡗ࡚ࠊ㛗㇂ඛ⏕ࡢ⺮ⓑ◊࡟ࡶࡈཧຍ࠸ࡓࡔ࠸࡚ࠊࢿࢵࢺ࣮࣡ࢡⓗ࡞ࡶࡢࢆసࡗ࡚࠸ࡃྲྀࡾ⤌ࡳࢆ㐍ࡵࡓ࠸࡜࠸࠺ᥦ᱌ࢆฟࡋ࡚
࠾ࡾࡲࡍࠋṧᛕ࡞ࡀࡽ㔜Ⅼㄢ㢟࡟ࡣ㑅ࡤࢀࡲࡏࢇ࡛ࡋࡓࡅࢀ࡝ࡶࠊᏛ⾡఍㆟ࡢ㑅ᐃࡋ࡚࠸ࡿ
኱ᆺࣉࣟࢪ࢙ࢡࢺࡢ୰࡟ࡣࡇࡢᥦ᱌ࡀධࡗ࡚࠾ࡾࡲࡍࠋࡑࢀࢆ࣮࣋ࢫ࡟௒ᚋ඲ᅜつᶍࡢࢿࢵࢺ࣮࣡ࢡࢆసࡾୖࡆࡿ᪉ྥ࡛ࡍࠋᇶ⏕◊࡜ࡋ࡚ࡣࡑ࠺࠸࠺᪉ྥࢆ┠ᣦࡋ࡚ࡇࢀ࠿ࡽࡶᴫ⟬せồࢆ⥆ࡅ࡚࠸ࡃ࡜࠸࠺❧ሙ࡟࠶ࡾࡲࡍࠋ

㸦3㸧ඛ࡯࡝ࡢ OBC ࡢ⤂௓࡛ࡍࠋ

㸦3㸧኱Ꮫ㝔⏕ࡢᩍ⫱࡟㛵ࡋ࡚࡛ࡍࠋࡇࢀࡣඛ࡯࡝ࡢ఍㆟ࡢ๓ࡢ࠾ヰࡋྜ࠸ࡢ࡜ࡁ࡟ࡶ
ฟ࡚࠸ࡲࡋࡓࡅࢀ࡝ࡶࠊⱝ࠸᪉ࢆࡁࡕࢇ࡜⫱࡚࡚࠸ࡃ࡜࠸࠺ࡇ࡜ࡀ࠸ࢁ࠸ࢁ࡞ព࿡࡛㞴ࡋ࠸᫬௦࡟ධࡗ࡚ࡁ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋࡶࡕࢁࢇᇶ⏕◊ࡣ⥲◊኱ࡢ⏕࿨⛉Ꮫ◊✲⛉࡟ᡤᒓࡋ࡚࠾
ࡾࡲࡍࡢ࡛ࠊࡑࡇࡢάືࢆ୰ᚰ࡟ḟୡ௦ࢆᢸ࠺ேᮦࢆసࡗ࡚࠸ࡁࡓ࠸࡜ດຊࡋ࡚࠸ࡲࡍࠋ

− 52 −

㸦3㸧ࡇࢀࡲ࡛ᇶ⏕◊࡟⡠ࢆ⨨࠸ࡓ኱Ꮫ㝔⏕ࡀ⌧ᅾ࡝࠺࠸࠺࡜ࡇࢁ࡛ά㌍ࡋ࡚࠸ࡿ࠿࡜
࠸࠺ࡇ࡜ࢆ୍ぴ⾲࡟ࡉࡏ࡚࠸ࡓࡔࡁࡲࡋࡓࠋ

㸦3㸧࠸࠸኱Ꮫ㝔⏕ࢆࣜࢡ࣮ࣝࢺࡋ࡚ࠊ࠸࠸ᩍ⫱ࢆ᪋ࡍ࡜࠸࠺ࡓࡵ࡟࡝࠺࠸࠺ࡇ࡜ࢆࡸ
ࡗ࡚࠸ࡿ࠿࡜࠸࠺ࡇ࡜ࢆࡲ࡜ࡵ࡚࠶ࡾࡲࡍࠋ

㸦3㸧⌧ᅾࡢᇶ⏕◊ࡢ඲యᵓ᝿ࢆ࣏ࣥࢳ⤮ⓗ࡟ࡲ࡜ࡵࡓࡶࡢ࡛ࡍࠋ⌧ᅾ㉮ࡗ࡚࠸ࡿࣉࣟ
ࢪ࢙ࢡࢺࡀࡇ࠺࠸࠺ᙧ࡟᭩ࡅࡿࡔࢁ࠺࡜࠸࠺ࡇ࡜࡛ࡍࠋ

㸦3㸧ඛ࡯࡝⏦ࡋୖࡆࡓ௒ᚋࡢ᪉ྥᛶ࡜ࡋ࡚ࠊᏛ⾡఍㆟ࡢ኱ᆺࣉࣟࢪ࢙ࢡࢺ࡟ἢࡗࡓᙧ
࡛㐍ࡵ࡚࠸ࡁࡓ࠸࡜࠸࠺ࡇ࡜ࡀᅗ♧ࡋ࡚࠶ࡾࡲࡍࠋ

㸦3㸧⤌⧊࡜ࡋ࡚኱ᆺࣉࣟࢪ࢙ࢡࢺࡢࢿࢵࢺ࣮࣡ࢡ࡟ࡇࢀࡲ࡛ࡢ࡜ࡇࢁ㈶ྠࡋ࡚࠸ࡓࡔ
࠸࡚࠸ࡿᶵ㛵ࡀᣲࡆ࡚࠶ࡾࡲࡍࠋ ࡜࠸࠺ࡇ࡜࡛ࠊ㠀ᖖ࡟㥑ࡅ㊊࡛⏦ࡋヂ࡞࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ⌧ᅾࡢᇶ⏕◊ࡢ≧ἣࢆᴫㄝࡉ
ࡏ࡚࠸ࡓࡔࡁࡲࡋࡓࠋ௨ୖ࡛ࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋࡑࢀ࡛ࡣࠊ࢔ࣥࢣ࣮ࢺ࡛ࡶ࠾♧ࡋࡋࡲࡋࡓࡼ࠺
࡟஬ࡘࡢ㡯┠ࠊࡑࡢᚋ࡛ᑗ᮶ィ⏬࠾ࡼࡧ◊✲ຊᙉ໬ᡓ␎ᐊ᪂タ࡜࠸࠺ࡇ࡜࡟ࡘ࠸࡚ࡈሗ࿌ࡉ
ࡏ࡚࠸ࡓࡔࡁࡓ࠸࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ ࡛ࡣࠊࡲࡎ➨㸯ࡢᏛ⾡◊✲ࡢ᥎㐍࡜࠸࠺Ⅼ࡟㛵ࡋ࡚ᢸᙜࡢ୺ᖿࡢ᪉࠿ࡽㄝ᫂ࡋ࡚࠸ࡓࡔࡁ
ࡓ࠸࡜ᛮ࠸ࡲࡍࠋ㔝⏣ඛ⏕ࠊ࠾㢪࠸ࡋࡲࡍࠋϨ Ꮫ⾡◊✲ࡢ᥎㐍㸦㔝⏣㸧 ࡑࢀ࡛ࡣࠊ➨㸯␒┠ࡢᏛ⾡◊✲ࡢ᥎㐍࡟ࡘ࠸࡚ࡈㄝ᫂࠸ࡓࡋࡲࡍࠋ㈨ᩱ㸯࡜㈨ᩱ
㸱ࢆぢ࡞ࡀࡽࡢㄝ᫂࡟࡞ࡾࡲࡍࠋ ᇶ♏⏕≀Ꮫ◊✲ᡤࡣ኱Ꮫඹྠ฼⏝ᶵ㛵ἲே࡛࠶ࡾࡲࡋ࡚ࠊࡈᢎ▱ࡢࡼ࠺࡟ᇶ┙◊✲࡜ඹྠ฼⏝◊✲ࡢ஧ࡘࡢᰕ࡛ࡶࡗ࡚ホ౯ࢆཷࡅࡿ࡜࠸࠺❧ሙ࡟࠶ࡾࡲࡍࠋඹྠ฼⏝◊✲ࡣ୺࡟㐠Ⴀ㈝஺௜㔠ࢆ౑ࡗ࡚⾜࠺◊✲ࠊࡲࡓࠊᇶ┙◊✲ࡣ୺࡟ྛேࡀ➇தⓗ㈨㔠ࢆ⋓ᚓࡋ࡚ࠊࡑࢀࡒࢀ
ࡢ◊✲㢟┠ࢆỴࡵ࡚⾜࠺◊✲࡜࠸࠺ᙧ࡟࡞ࡗ࡚࠸ࡿ࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋඹྠ฼⏝◊✲ࡣࡶࡕࢁࢇ኱஦࡞ࢃࡅ࡛࠶ࡾࡲࡍࡀࠊࡑࢀࡒࢀࡢᩍဨࠊ◊✲⪅ࡀ➇தⓗ㈨㔠ࢆ⋓ᚓࡋ࡚⾜࠺ᇶ┙◊✲ࡢ㔞࡜㉁ࡢྥୖࡶࠊ㠀ᖖ࡟኱஦࡛࠶ࡿ࡜఩⨨࡙ࡅ࡚࠾ࡾࡲࡍࠋ
 ㈨ᩱ㸯㸦3㸧࡟ࠊᇶ┙◊✲ࡢᡂᯝࡢ㸯࠿ࡽ  ࡲ࡛ࡢ㢟┠ࡀᥖࡆࡽࢀ࡚࠾ࡾࡲࡍࠋࡇࢀࡣ
㒊㛛ࠊ◊✲ᐊࠊ࠶ࡿ࠸ࡣ᪋タࡢᩍဨࡀ  ᖺᗘ࡟ᣲࡆࡓᡂᯝࡢ୺࡞ࡶࡢࢆࣜࢫࢺ࢔ࢵࣉࡋࡓࡶ
ࡢ࡛ࡍࠋඛ࡯࡝ࡢ㈨ᩱ㸱㸦3㸧ࡢㄝ᫂࡟ࡶ࠶ࡾࡲࡋࡓࡼ࠺࡟ࠊ◊✲㈨㔠࡜ࡋ࡚ࡣ࠿࡞ࡾࡢ
㒊ศࢆ⛉Ꮫ◊✲㈝⿵ຓ㔠ࢆࡣࡌࡵ࡜ࡋࡓ➇தⓗ㈨㔠ࡀ༨ࡵ࡚࠾ࡾࡲࡍࡢ࡛ࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡣᇶ┙◊✲ࡢ㒊ศࡀ㠀ᖖ࡟┒ࢇ࡟⾜ࢃࢀ࡚࠸ࡿ࡜ゝ࠼ࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ

− 53 − ≉࡟࠸ࡕ࠸ࡕㄞࡳୖࡆࡲࡏࢇࡀࠊඛ࡯࡝ࡢㄝ᫂࡟ࡶ࠶ࡾࡲࡋࡓࡼ࠺࡟ࠊ࠸ࢃࡺࡿ࢖ࣥࣃࢡ
ࢺࣇ࢓ࢡࢱ࣮ࡢ㧗࠸ࢪ࣮ࣕࢼࣝ࡟ࢥࣥࢫࢱࣥࢺ࡟ᥖ㍕ࡉࢀࠊ࠿ࡘࡑࡢᘬ⏝ᗘᩘ࠿ࡽࡶ㐃⥆ࡋ୍࡚ᐃࡢホ౯ࢆᚓ࡚࠸ࡿ࡜⪃࠼࡚࠾ࡾࡲࡍࠋ ኱యㄝ᫂࡜ࡋ࡚ࡣ௨ୖ࡛ࡍࠋఱ࠿ࡈ㉁ၥࡀࡈࡊ࠸ࡲࡋࡓࡽࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋᇶ⏕◊ࡢ୰࡛ୡ⏺ࢆඛᑟࡍࡿࡼ࠺࡞◊✲ࢆ๰ᡂ࣭᥎㐍ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠾ࡾࡲࡍࠋᡤෆ◊✲⪅ࡢ◊✲Ỉ‽࡞ࡽࡧ࡟◊✲ෆᐜ࡟ࡘ࠸࡚࠾ఛ࠸
ࡍࡿ࡜࡜ࡶ࡟ࠊ௒ᚋ⏕≀Ꮫ࡟ࣈ࣮ࣞࢡࢫ࣮ࣝࢆࡶࡓࡽࡍ◊✲ࢆ⫱࡚࡚ᒎ㛤ࡋ࡚࠸ࡃࡓࡵ࡟◊✲ᡤࡀ࡝ࡢࡼ࠺࡞௙⤌ࡳࢆᣢࡘ࡭ࡁ࠿࡜࠸࠺ࡇ࡜࡟ࡘ࠸࡚ࡈពぢࢆ࠾ఛ࠸ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋ㸦Ⲩᮌ㸧 ࡕࡻࡗ࡜㉁ၥࡀ࠶ࡿࡢ࡛ࡍࡀࠊࡼࢁࡋ࠸࡛ࡍ࠿ࠋ௒ࡢ㠀ᖖ࡟ᇶ♏ⓗ࡞◊✲ࢆᨭ࠼ࡿୖ࡟࠾࠸࡚ࠊ౛࠼ࡤ➇தⓗ㈨㔠ࢆྲྀࡿࡇ࡜ࡀࡸࡣࡾ㔜せ࡛ࡍࡼࡡࠋࡑࡢࡓࡵࡢດຊࡣఱ࠿
ࡉࢀ࡚࠸ࡿࡢ࡛ࡋࡻ࠺࠿ࠋࡼࡃྲྀࡽࢀ࡚࠸ࡿ࡜ࡣᛮ࠸ࡲࡍࡀࠋ
㸦㔝⏣㸧 ⚾ࡀ⟅࠼ࡿࡢࡀ㐺ᙜ࠿࡝࠺࠿ศ࠿ࡽ࡞࠸࡛ࡍࡀࠊ≉࡟◊✲ᡤ࡜ࡋ࡚ࠊ➇தⓗ◊✲㈝ࢆ࠸࠿࡟⋓ᚓࡍࡿ࠿࡜࠸࠺ࡇ࡜࡛⤌⧊ࡔࡗ࡚άືࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡣࡈࡊ࠸ࡲࡏࢇࠋࡑ
ࢀࡒࢀࡢ◊✲⪅ࡀྛ⮬ࡢ◊✲άື࡟ᇶ࡙࠸࡚ಶே࡜ࡋ࡚ດຊࡋࡓᡂᯝࡀࡇࡢࡼ࠺࡞⋓ᚓ≧ἣ࡟࡞ࡗ࡚࠸ࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ௜ࡅຍ࠼ࡲࡍ࡜ࠊࡑࡢࡼ࠺࡞≉ู࡞ࡇ࡜ࡣࡋ࡚࠸ࡲࡏࢇࡅࢀ࡝ࡶࠊ୍ࡘࡣࢥ࣑ࣗ
ࢽࢸ࢕࣮࡟ᑐࡋ࡚ᇶ⏕◊ࡀ㔜せ࡞ᙺ๭ࢆᯝࡓࡏࡿࡼ࠺࡟࡜࠸࠺ࡇ࡜࡛ࠊ≉࡟᪂Ꮫ⾡㡿ᇦࡸࠊࡑ࠺࠸࠺ࢢ࣮ࣝࣉ◊✲ࡢ࣮ࣜࢲ࣮ࡸ௦⾲࡟࡞ࡿࡇ࡜ࢆ᥎㐍࣭ዡບࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡣࡈࡊ
࠸ࡲࡍࠋ௒ࠊᐇ㝿࡟ࡶ࠿࡞ࡾࡢ᪉ࡀ᪂Ꮫ⾡㡿ᇦࡢ௦⾲⪅࡟࡞ࡗ࡚ࠊࡑࡢ㡿ᇦࢆ㐠Ⴀࡋ࡚࠾ࡽࢀࡲࡍࠋ㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ௒ࡢ࡜ࡇࢁࡣࠊ௒ࡢࡈㄝ᫂ࡢࡼ࠺࡟ಶࠎࡢ◊✲⪅ࡢ᪉ࡢດຊ࡛࡜࠸
࠺ࡇ࡜ࡔ࡜ᛮ࠸ࡲࡍࠋᑡࡋࡑࢀ࡟㛵㐃ࡍࡿ࠿ࡶࡋࢀ࡞࠸ࡢࡣࠊURA ࡢไᗘࡀጞࡲࡗ࡚ࠊ኱Ꮫ
࡞࡝࡟ࡼࡗ࡚ࡣ URA ࡢ᪉ࡢ኱ࡁ࡞࣑ࢵࢩࣙࣥࡀእ㒊㈨㔠ࡢᑟධ࡜࠸࠺࡜ࡇࢁ࡟ྥࡅࡽࢀ࡚
࠸ࡿ࡜ࡇࢁࡶ࠶ࡿࡸ࡟⪺࠸࡚࠸ࡲࡍࠋ እ㒊㈨㔠ࡢເ㞟ࡀ࠶ࡗࡓ࡜ࡁ࡟ࠊࡑࢀࡀ࡝࠺࠸࠺ࡶࡢࢆ᝿ᐃࡋ࡚ฟࡉࢀ࡚࠸ࡿ࠿࡜࠸࠺ࡇ
࡜ࢆࡁࡕࢇ࡜ศᯒࡋ࡚ࠊࡑࢀ࡟ྜ࠺ࡼ࠺࡟ᥦゝࡸᥦ᱌ࢆࡲ࡜ࡵୖࡆࡿ࠾ᡭఏ࠸ࢆࡋ࡚࠸ࡃ࡜
࠸࠺ࡇ࡜ࡶጞࡲࡗ࡚࠸ࡿࡼ࠺࡞ࡢ࡛ࡍࡀࠊ௒ࡢ࡜ࡇࢁࠊࢃࢀࢃࢀᇶ⏕◊ࠊ࠶ࡿ࠸ࡣ⮬↛⛉Ꮫ◊✲ᶵᵓࡣ࠶ࡲࡾࡑࡇ࡟ࡣຊࢆὀ࠸࡛࠸ࡲࡏࢇࠋࡑࢀࡀࡇࡢࡲࡲ࠸ࡃࡢ࠿ࠊኚࢃࡗ࡚࠸ࡃࡢ
࠿ࡲࡔࡕࡻࡗ࡜ศ࠿ࡾࡲࡏࢇࠋ኱Ꮫࡔ࡜ URA ࡢ᪉ࡀࡑ࠺࠸࠺ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿ࡜࠸࠺ࡇ
࡜ࡀ࠶ࡿࡼ࠺࡛ࡍࡡࠋ
㸦ኴ⏣㸧 ࡑ࠺࡛ࡍࡡࠋ࠺ࡕࡢ㒊ᒁ࡛ࡶ URA ࡢ᪉ࡀࡇࡢ᫓࠿ࡽάືࢆጞࡵࡽࢀ࡚ࠊᨻᗓࡀ

− 54 −

ฟࡋ࡚࠸ࡿࡉࡲࡊࡲ࡞◊✲ࣉࣟࢪ࢙ࢡࢺ࡛ࠊᐇ㝿࡟බເࡀጞࡲࡿ๓࡟࡝࠺࠸࠺⤌ࡳྜࢃࡏ࡟
ࡋࡼ࠺࡜ࡋ࡚࠸ࡿ࡜࠸࠺ືࡁࡀ࠶ࡿ࠿ࡽࠊ
ࠕࡇࡇࡣ࠶࡞ࡓࡀࡕࡻ࠺࡝࠸࠸ࡢ࡛ࡣ࡞࠸࠿ࠖ࡜࠿
࡜࠸࠺ࡢ࡛άືࢆጞࡵࡽࢀ࡚࠾ࡾࡲࡍࠋ ኱Ꮫࡣ㞧⏝ࡀ㠀ᖖ࡟ከࡃ࡚ࠊ࡞࠿࡞࠿ࡑ࠺࠸࠺ࡶࡢ࡟㛵ࢃࢀ࡞࠸ࡶࡢ࡛ࡍ࠿ࡽࠊࡑ࠺࠸࠺
ࡇ࡜ࢆࡸࡗ࡚ࡃࡔࡉࡿᑓ㛛ࡢ᪉ࡀ࠸ࡽࡗࡋࡷࡿ࡜㠀ᖖ࡟ຓ࠿ࡿ࡜࠸࠺࠿ࠊලయⓗ࡟ࣉࣟࢪ࢙
ࢡࢺ࡟ධࡗ࡚࠸ࡁࡸࡍࡃ࡞ࡿ࡜࠸࠺ឤゐࢆᣢࡗ࡚࠾ࡾࡲࡍࠋ㸦すᮧ㸧 ᇶ⏕◊ࡶ㞧⏝ࡀከ࠸ࡢ࡛ URA ไᗘࢆ࠺ࡲࡃά⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊእ㒊㈨㔠ࡢ⋓ᚓ࡟ࡶᐤ୚࡛ࡁࡿࡼ࠺࡞ࡇ࡜ࢆ⪃࠼࡚࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ㸦すᮧ㸧 ௚࡟ࠊᏛ⾡◊✲࡟㛵ࡋ࡚ࡈពぢࡸࡈ㉁ၥࡣࡈࡊ࠸ࡲࡍ࠿ࠋ
㸦㛗㇂㸧 ⊂⮬ࡢ㈨㔠ࢆྲྀࡗ࡚ࠊ⊂⮬ࡢ◊✲࡟ᑐࡍࡿ࣏ࣜࢩ࣮࡛ࡸࡗ࡚࠸ࡗ࡚ࠊ⤌⧊࡜ࡋ࡚ࡲ࡜ࡲࡗ࡚࠸ࡿ࡜࠸࠺ጼࡣ኱ኚ⣲ᬕࡽࡋ࠸࡜ᛮ࠺ࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊྛ◊✲⪅ಶேࡢ⊂⮬ᛶࢆᑛ㔜ࡋࡘࡘࠊ࡞࠾࠿ࡘ⤌⧊࡜ࡋ࡚ࡢᑗ᮶ࡶぢᤣ࠼ࡓࠕࡲ࡜ࡲࡾࠖ࡜࠸࠺࠿ࠊ᪉ྥᛶࢆᡤ㛗ࡢୗ࡟సࡾฟࡋ࡚࠸ࡃ࡜࠸࠺ࡢࡀ௒ᚋ◊✲ᡤ࡟ㄢࡏࡽࢀࡿ࣑ࢵࢩࣙࣥࡢ኱ࡁ࡞୍ࡘࡔ࡜ᛮ࠺
ࢃࡅ࡛ࡍࠋࡔ࠿ࡽࠊྛಶேࡀࡋࡗ࠿ࡾࡸࡗ࡚࠸ࢀࡤࡑࢀ࡛࠸࠸ࡢ࠿࡜࠸࠺ࡢࡣᑡࡋ㐪࠺ࡢ࡛ࠊࡐࡦ⤌⧊࡜ࡋ࡚ࡢ᫂☜࡞᪉ྥᛶࢆᡤෆ࡛࠾⪃࠼࡟࡞ࡿࡇ࡜ࡣ኱ኚ኱஦ࡔࢁ࠺࡜ᛮࡗ࡚࠾ࡾࡲ
ࡍࠋ ึࡵ࡚ࡇࡇ࡟࠶ࡿ୐ࡘࡢ◊✲㡿ᇦࢆぢࡏ࡚࠸ࡓࡔࡁࡲࡋࡓࡀࠊࡇࡢ㡿ᇦྡࡶྠ୍ࣞ࣋ࣝࡢ
ࡶࡢࡢ⪃࠼᪉࡛ࡣ࡞ࡃ࡚ࠊᑡࡋࡤࡽࡘ࠸࡚࠸ࡿࡼ࠺࡞༳㇟ࡶ࠶ࡾࡲࡍࠋ౛࠼ࡤ⣽⬊⏕≀ᏛࠊⓎ⏕⏕≀Ꮫࠊ⚄⤒⏕≀Ꮫ࡜࠸࠺ࡼ࠺࡞㡿ᇦ࡜ࠊ⌮ㄽ⏕≀Ꮫ࡜࠸࠺ࡢࡶࡶࡕࢁࢇ㡿ᇦ࡛ࡍࡅࢀ
࡝ࡶࠊ⌮ㄽ⏕≀Ꮫ࡛⣽⬊⏕≀ᏛࢆࡸࡿࠊⓎ⏕⏕≀Ꮫࢆࡸࡿࠊ⚄⤒⏕≀Ꮫࢆࡸࡿ࡜࠸࠺ࡼ࠺࡞
᪉ἲㄽ࡜◊✲ᑐ㇟ࠊ࠶ࡿ࠸ࡣࡑࡢ௚ࡢㅖࠎࡢྡ๓ࡢ௜ࡅ᪉ࡀࡑࢀࡒࢀࡢ◊✲⪅ࡢ⊂⮬ᛶࢆ཯ᫎࡋࡓࡲࡲṧࡗ࡚࠸ࡿࡼ࠺࡟ᛮࢃࢀࡲࡍࠋࡍࡄ࡟࡝࠺ࡢࡇ࠺ࡢ࡜࠸࠺ヰ࡛ࡣ࡞࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠋ㸦ᒣᮏ㸧 ᇶ⏕◊ࡢྛඛ⏕᪉ࡀࠊᡤෆ࡛௚ࡢ㒊㛛ࡢ᪉ࠎࠊ౛࠼ࡤ௒ࡈᣦ᦬ࡢ࠶ࡗࡓ⌮ㄽ⏕≀Ꮫ㡿ᇦࡢ᪉࡜࡝࠺࠸࠺࢖ࣥࢱࣛࢡࢩࣙࣥࢆࡋ࡚࠸ࡿ࠿࡞࡝ࡢ౛ࡣ࠾࠶ࡾ࡛ࡋࡻ࠺࠿ࠋ㸦すᮧ㸧 ࡑࢀࡲ࡛ࡣ◊✲⣔࡜࠸࠺ᙧࡔࡗࡓࡢ࡛ࡍࡀࠊἲே໬ࡢ᫬࡟࠶ࡿ⛬ᗘࡢᅛࡲࡾ࡜ࡋ
࡚㡿ᇦ࡟ศࡅࡲࡋࡓࠋࡑࡢ࡜ࡁࡢ㆟ㄽࡢ୰࡛ࡣࠊ᪉ἲㄽ࡜࠿ࡑ࠺࠸࠺ᙧ࡛ࡣ࡞ࡃ࡚ࠊ኱Ꮫ㝔ࡢㅮ⩏࡜ࡶ㛵㐃ࡉࡏ࡞ࡀࡽ኱ࡲ࠿࡞ᅛࡲࡾ࡟ศࡅࡓ࡜࠸࠺ὶࢀ࡛ࡋࡓࠋࡑ࠺࠸࠺ព࿡࡛ࠊ⤫୍ⓗ࡟᳨ウࡋ࡚ࡁࡓ࡜࠸࠺≧ἣ࡛ࡣ࡞࠸ࡶࡢ࡛ࡍ࠿ࡽࠊ௒ࡢ࠾ヰࡣࠊከศᑗ᮶ⓗ࡞࡜ࡇࢁ࡜
ࡋ࡚ࡣࠊᑗ᮶ᵓ᝿ࢆぢᤣ࠼࡞ࡀࡽࠊᩚྜᛶࡀྲྀࢀࡓᙧ࡛㡿ᇦ࡜࠸࠺ࡢࢆసࡾ┤ࡍ࡜࠸࠺ࡢࡣ

− 55 −ᚲせ࡞ࡇ࡜ࡔ࡜⚾ࡶᛮ࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 ఱ࠿㏣ຍ࡛࠶ࡾࡲࡍ࠿ࠋ
㸦㔝⏣㸧 ඛ࡯࡝ㄝ᫂ࡀ࠶ࡾࡲࡋࡓࡼ࠺࡟ࠊタ❧ᙜึࡣ◊✲⣔࡜࠸࠺ࢢ࣮ࣝࣉࡀ࠶ࡾࠊ୍ࡘ
ࡢ⣔࡟㸲㒊㛛ࡄࡽ࠸ࡎࡘ㓄⨨ࡉࢀ࡚࠸ࡓࢃࡅ࡛ࡍࡀࠊࡑࡇ࡛ࡲ࡜ࡲࡾࡀ࠶ࡿ᪉ࡀ࠸࠸࡜࠸࠺ពぢࡶ࠶ࢀࡤࠊࡑࡢ⣔࡟୺ᖿ࡜࠸࠺ࡶࡢࡀ௜࠸࡚࠸ࡓ᫬ᮇࡀࡈࡊ࠸ࡲࡋ࡚ࠊࡑࡢ୺ᖿࡢᣦᑟ
ຊࡀᙉࡃ࡞ࡾࡍࡂࡿࠊ◊✲ᐊࡢ⊂❧ᛶࢆᢸಖࡋ࡚࡯ࡋ࠸࡜࠸࠺せᮃࡀⱝ࠸ᩍᤵࡢ᪉࠿ࡽฟࡓ
᫬ᮇࡀ࠶ࡾࡲࡍࠋࡑࢀ୍࡛ᗘࠊ⣔ࢆ࡞ࡃࡋ࡚㒊㛛ྡࡔࡅ࡛ࡸࢁ࠺࡜ࡋࡓࡢ࡛ࡍࡀࠊࡉࡍࡀ࡟ 㒊㛛ࡀ඲㒊ࡤࡽࡤࡽ࡜࠸࠺ࡢࡶࡸࡣࡾ࠾࠿ࡋ࠸ࠊ↓⌮ࡀ࠶ࡿ࡜࠸࠺ࡇ࡜࡛ࠊ௒ࡢࡼ࠺࡞ᙧ
ࠕ㡿ᇦ࡛ࠖศ㢮ࡋࡓ࡜࠸࠺ࡼ࠺࡞⤒⦋ࡀ࠶ࡾࡲࡍࠋ୍㈏ᛶࡀ࡞࠸࡜ぢ࠼ࡿ㒊ศࡶṧࡗ࡚࠸ࡿࡢࡣࡑࡢࡏ࠸࡛ࡣ࡞࠸࠿࡜ᛮ࠸ࡲࡍࠋඛ⏕ࡢ࠾ࡗࡋࡷࡽࢀࡓࡼ࠺࡟ࠊ◊✲ᡤ࡜ࡋ࡚ࡢ᪉ྥᛶ
࡜࠸࠺ࡶࡢࢆ㆟ㄽࡍࡿ㐣⛬࡛ࠊࡇࡢࠕ㡿ᇦࠖࡶᩚ⌮ࡋ࡚࠸ࡃ࡜࠸࠺ࡇ࡜ࡀᚲせ࡟࡞ࡗ࡚ࡃࡿ
࠿ࡶࡋࢀ࡞࠸࡜ᛮ࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 㛗㇂ඛ⏕ࡀ࠾ࡗࡋࡷࡗࡓࡼ࠺࡟ࠊ◊✲⪅ࡢಶேࣉ࣮ࣞࡔࡅ࡛ࡣࡲࡎ࠸ࡢ࡛ࡣ࡞࠸
࠿࡜࠸࠺ࡇ࡜ࡣࡑࡢ࡜࠾ࡾࡔ࡜ᛮ࠸ࡲࡍࡋࠊࡇࢀࡶ௒ࡕࡻࡗ࡜すᮧඛ⏕࠿ࡽࡈㄝ᫂ࡀ࠶ࡾࡲ
ࡋࡓࡅࢀ࡝ࡶࠊ㡿ᇦ࡜ࡋ࡚ࡇ࠺࠸࠺ࡩ࠺࡟ศࡅ࡚࠸ࡲࡍࡀࠊศࡅࡓ୰࡛≉࡟ఱ࠿ࢆࡋ࡚࠸ࡿ
࡜࠸࠺ࡇ࡜ࡶ࠶ࡲࡾ࡞࠸ࡢ࡛ࡍࡡࠋᐇ㝿࡟ࡣ⥲◊኱ࡢᩍ⫱ࣉࣟࢢ࣒ࣛࢆసࡿ࡜ࡁ࡟ࡇ࠺࠸࠺
ศ㢮ࡀຠ࠸࡚ࡃࡿ࡜࠸࠺ࡢࡀ୍␒኱ࡁ࡞ศࡅࡓ⌮⏤࠿ࡶࡋࢀ࡞࠸࡜ᛮ࠸ࡲࡍࠋࡑࢀ௨እࡢ࠸
ࢁ࠸ࢁ࡞ࡇ࡜ࢆỴࡵࡿ㝿ࡣᡤ඲య࡛⪃࠼࡚࠸ࡲࡍࡢ࡛ࠊࡇࡢ㡿ᇦࡢ୰࡛ఱ࠿ࢆ≉ẁỴࡵࡿ࡜࠸࠺ࡼ࠺࡞ᙧ࡟ࡣ࡞ࡗ࡚࠸࡞࠸⌧≧࡛ࡍࠋ ࡑࢀ࠿ࡽࠊ᭱㏆ࡣୖ࡟❧ࡘ኱ᏛࡢᏛ㛗ࡸᶵᵓࡢᶵᵓ㛗࡞࡝ࡢ࣮ࣜࢲ࣮ࢩࢵࣉࡀ࡞࠸࡜࠸ࡅ
࡞࠸࡜࠸࠺ࡢࡀᩥ⛉┬ࡢ㠀ᖖ࡟ᙉ࠸୍ࡘࡢุ᩿ᇶ‽࡟࡞ࡗ࡚ࡁ࡚࠸ࡲࡍࠋ⚾ࡶࡲࡔ඲యࡀぢ㏻ࡏ࡚࠸࡞࠸࡜࠸࠺ࡇ࡜ࡀ࠶ࡾࡲࡍࡅࢀ࡝ࡶࠊࡑࢀࡒࢀࡢ◊✲㒊㛛ࠊ◊✲ࢢ࣮ࣝࣉࡢάື࠿
ࡽ㣕ࡧ㞳ࢀࡓࡶࡢ࡛ࡣ࡞ࡃ࡚ࠊࡑࡢ୰࠿ࡽᑡࡋඛࡢᑗ᮶ࡀぢ࠼࡚ࡃࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡀ࠶
ࢀࡤࠊࡑࡇ࡟኱ࡁ࡞ຊࢆὀ࠸࡛࠸ࡃ࡜࠸࠺ᙧ࡛㐍ࡵࡿࡢࡀྲྀࡾ࠶࠼ࡎࡣጇᙜ࡞ࡢ࠿࡞࡜⪃࠼࡚࠸ࡿ࡜ࡇࢁ࡛ࡍࠋ
 ඲య࡜ࡋ࡚ࡣࡸࡣࡾ᪉ྥᛶࢆࡁࡕࢇ࡜ࡋ࡚࠸࠿࡞࠸࡜࠸ࡅ࡞࠸࡜࠸࠺ࡇ࡜ࡣࠊᖖ࡟࠸ࢁ࠸
ࢁ࡞࡜ࡇࢁ࠿ࡽᣦ᦬ࡉࢀࡿࠊ࡜࠸࠺ࡼࡾࡶࡘࡘ࠿ࢀࡿࡼ࠺࡞≧ἣ࡟࡞ࡗ࡚࠸ࡲࡍࠋࡇࢀࡲ࡛
ࡢ࡜ࡇࢁࡣࡑࡢሙࠊࡑࡢሙ࡛ᑐᛂࡋ࡚࠸ࡿ࡜࠸࠺ࡢࡀᐇ᝟࠿ࡶࡋࢀࡲࡏࢇࡅࢀ࡝ࡶࠊ㛗㇂ඛ⏕ࡢ࠾ࡗࡋࡷࡿࡼ࠺࡟ࠊ኱ࡁ࡞ព࿡࡛ࡇࡢ◊✲ᡤࡀᑗ᮶࡝࠺࠸࠺ࡩ࠺࡟࠶ࡿ࡭ࡁ࠿࡜࠸࠺ࡢ
ࡣࠊⓙࡉࢇ࡜㆟ㄽࢆ㐍ࡵ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡲࡍࠋ㸦すᮧ㸧 ࡼࢁࡋ࠸࡛ࡍ࠿ࠋࡑࢀ࡛ࡣࠊሷぢඛ⏕ࠊఱ࠿ࡇࡢⅬ࡟㛵ࡋ࡚ࡈពぢࡀࡈࡊ࠸ࡲࡍ
࡛ࡋࡻ࠺࠿ࠋ

− 56 −㸦ሷぢ㸧 ⤌⧊࡜ࡋ࡚ࠊ౛࠼ࡤ෸ᩍᤵࡢ᪉࡛⊂❧ࡉࢀ࡚࠸ࡿேࡀ⤖ᵓ࠾ࡽࢀࡲࡍࡼࡡࠋࡇࡢ
◊✲ᡤࡣᬑ㏻ࠊᩍᤵ࡬ࡢࣉ࣮ࣟࣔࢩࣙࣥࡣ࡞࠸ࢃࡅ࡛ࡋࡻ࠺ࠋ
㸦ᒣᮏ㸧 ࡣ࠸ࠋ㸦ሷぢ㸧 ࡑ࠺࠸࠺ேࡓࡕࢆ࡝࠺ࡋ࡚࠸
ࡃࡢ࠿࡞࡜࠸ࡘࡶᛮࡗ࡚࠸ࡿࡢ࡛ࡍࠋከ
ศ࠸ࢁ࠸ࢁ࡞◊✲ࡢ࢔ࢡࢸ࢕ࣅࢸ࢕ࢆ㧗ࡵ࡚࠸ࡃࡓࡵ࡟ࡣࠊ୍ࡘࡣࡶࡕࢁࢇ࠺ࡲ
࠸ࡇ࡜ᅇ㌿ࡉࡏ࡚࠸ࡃ࡜࠸࠺ࡼ࠺࡞ࡇ࡜
࡛ࠊࡑࢀࡣࡶࡕࢁࢇᩍᤵࡢ᪉ࡶྵࡵ࡚࡛
ࡋࡻ࠺ࡅࢀ࡝ࡶࠊࡑ࠺࡞ࡿ࡜ࠊ౛࠼ࡤ෸
ᩍᤵ࡛⊂❧ࡋ࡚ࣛ࣎ࢆᣢࡗ࡚࠸ࡿேࡓࡕ
ࡀ࠸࠿࡟࠸࠸௙஦ࢆฟࡋ࡚࠸࠿ࢀࡿ࠿࡜
࠸࠺ࡇ࡜ࡀ㔜せ࡟࡞ࡗ࡚ࡃࡿ࡜ᛮ࠺ࡢ࡛ࡍࠋ ⤌⧊࡜࠸࠺ࡢࡣࠊࡶࡕࢁࢇࡑࢇ࡞࡟⡆༢࡟ே஦࡞࡝࡛ࡁ࡞࠸ࡢ࡛ࠊࡍࡄ࡟࡝࠺ࡢࡇ࠺ࡢ࡜࠸࠺ࡇ࡜ࡣ࡛ࡁ࡞࠸࡜ᛮ࠸ࡲࡍࡀࠊࡑ࠺
࠸࠺ேࡓࡕࡀࡶ࠺ࡕࡻࡗ࡜ά㌍࡛ࡁࡿࡼ࠺࡟࡞ࡽ࡞࠸࠿࡞࡜ᛮ࠺ࡢ࡛ࡍࠋ࡛ࡣ࡝࠺ࡋࢁ࡜ゝࢃࢀࡿ࡜ࠊ൅ࡶ࠶ࡲࡾ࢔࢖ࢹ࢔ࡣ࡞࠸ࡢ࡛ࡍࡀࠋ㸦すᮧ㸧 ⊂❧෸ᩍᤵࡢ࡜ࡇࢁࢆ࡝ࡢࡼ࠺࡟Ⓨᒎࡉࡏࡽࢀࡿ࠿࡜࠸࠺ࡇ࡜ࡔ࡜ᛮ࠸ࡲࡍࠋ☜࠿࡟ࠊ≉௵ࢆྵࡵࡲࡍ࡜⊂❧ࡋࡓ෸ᩍᤵࡀቑ࠼࡚ࡁ࡚࠾ࡾࡲࡍࠋࡑࡇ࡟ᑐࡋ࡚࡝ࡢࡼ࠺࡞ᙧ
ࡢࢧ࣏࣮ࢺࢆࡍࡿ࠿࡜࠸࠺ࡢࡣ௒ᚋࡢ᳨ウㄢ㢟࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ࡞࠿࡞࠿㞴ࡋ࠸ၥ㢟࡛ࡍࡡࠋ࡝࠺࡛ࡋࡻ࠺ࠋ࡝ࡇ࠿࡛ࡇ࠺࠸࠺࠺ࡲ
࠸ࡇ࡜ࢆࡸࡗ࡚࠸ࡿ࡜ࡇࢁࡀ࠶ࡿ࡜࠸࠺ࡼ࠺࡞ᐇ౛ࢆࡈᏑࡌ࡛ࡍ࠿ࠋ
㸦ኴ⏣㸧 ⌮໬Ꮫ◊✲ᡤ࡟࠸ࡓ࡜ࡁࡣࠊ⚾ࡣ୺௵◊✲ဨࡸ◊✲ࣘࢽࢵࢺ࣮ࣜࢲ࣮ࢆࡋ࡚࠸ࡓ
ࡢ࡛ࡍࡀࠊࡑࡢ࡜ࡁࡣࠊ୺௵◊✲ဨࡢࢩࢽ࢔ࡢ࣓ࣥࣂ࣮ࡀ㸯ே࣓ࣥࢱ࣮࡜࠸࠺࠿ࠊ௒ᚋࡢ࢟
ࣕࣜ࢔ࢹࢨ࢖ࣥ࡞࡝ࡢ┦ㄯᙺࡳࡓ࠸࡞ேࡀ㸯ேࡣ௜࠸࡚࠸࡚ࠊࡑࡢே࡟࠸ࢁ࠸ࢁ┦ㄯࡍࡿ࡜ᩍ࠼࡚ࡃࢀࡿ࡜࠸࠺యไࡣ࠶ࡾࡲࡋࡓࠋᙧ㧁໬ࡋ࡚࠸ࡿ㒊ศࡶ࠶ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸
࠺௙⤌ࡳࡣ࠶ࡗ࡚ࡶ࠸࠸ࡢ࠿࡞࡜࠸࠺ࡇ࡜ࢆࡕࡻࡗ࡜⪃࠼࡚࠸ࡓࡾࡣࡋࡲࡋࡓࠋ௒ࡢẁ㝵࡛ࡣࡑ࠺࠸࠺ࡢࡣ≉࡟࡞࠸࡛ࡍ࠿ࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ௒ࡢ࡜ࡇࢁ≉࡟࣓ࣥࢱ࣮ࢆỴࡵ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡣ࡞࠸࡛ࡍࡡࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ

− 57 −

㸦ᒣᮏ㸧 ࡴࡋࢁ㏫࡟࠶ࡿព࿡ࠊ⊂❧ᛶࢆᢸಖࡋ࡚࠸ࡿ࡜࠸࠺࠿ࠋ
㸦ኴ⏣㸧 ࠶࠶ࠊࡑࢀࢆ኱஦࡟ࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦ᒣᮏ㸧 ࡣ࠸ࠋ㸦ኴ⏣㸧 ࡛ࡶࠊࡑࢀࡣ࣓ࣥࢱ࣮ࡢேࡀཱྀ࠺ࡿࡉࡃゝࡗ࡚ࡃࡿ࡜࠸࠺ࡢ࡛ࡣ࡞ࡃ࡚ࠊ࠶ࡃࡲ
࡛ຓゝᙺ࡞ࡢ࡛ࡍࠋ
㸦ᒣᮏ㸧 ࡣ࠸ࠋ㸦᳃㸧 ⚾ࡶኴ⏣ඛ⏕࡜ྠࡌពぢ࡛ࠊ⏕⌮◊ࡶ࣮ࣝࣝ࡜ࡋ࡚ࡶ࠺⤯ᑐ࡟෸ᩍᤵࠊPI ࠿ࡽୖ࡟⾜ࡅ࡞࠸࡜࠸࠺ࡢࡀ࠶ࡾࡲࡍࠋᇶ⏕◊ࡢሙྜࡶࡑ࠺࠸࠺࠾ヰࢆ⪺࠸࡚ࠊ౛࠼ࡤᾏእ࡛࣏ࢫࢻ
ࢡ࡛㠀ᖖ࡟ඃࢀࡓ◊✲ࢆࡉࢀࡓ᪉ࡀࠊࡲࡔⱝᡭ࡜࠸࠺ࡇ࡜࡛෸ᩍᤵ࡜ࡋ࡚ PI ࡟࡞ࡿ࡜࠸࠺ࢣ
࣮ࢫࡀከ࠸࡜ᛮ࠺ࡢ࡛ࡍࡡࠋ࡛ࡶࠊ᪥ᮏ࡟ᖐࡗ࡚ࡇࡽࢀ࡚ࠊሷぢඛ⏕ࡢࡼ࠺࡟㸳ᖺ࡛ࡑࡢே
ࡀࣛࢫࢺ࣮࢜ࢧ࣮࡛ࡁࡗࡕࡾࡋࡓㄽᩥࡀ᭩ࡅࡿேࡀ࠸ࡿ࠿࡜ලయⓗ࡟ᇶ⏕◊ࠊ⏕⌮◊࡛⪃࠼࡚ࡳࡿ࡜ࠊᐇࡣࡑࢇ࡞࡟࠸࡞࠸ࡢ࡛ࡍࠋู࡟ࠕCellࠖࠕNatureࠖࠕScienceࠖ࡟ฟࡏ࡜࠸࠺ࢃࡅ࡛
ࡣ࡞࠸ࡢ࡛ࡍࡀࠊࡸࡣࡾࡁࡕࢇ࡜ࡋࡓᏛ⾡ⓗ࡞࢖ࣥࣃࢡࢺࡀᮏᙜࡢព࿡࡛࠶ࡿ࡜࠸࠺ࡶࡢࢆ
ฟࡏ࡚࠸࡞࠸ࡼ࠺࡞Ẽࡀ⚾ࡣࡋ࡚࠸ࡲࡍࠋࡑࢀࡣ࠺ࡕࡢ኱Ꮫ࡛ࡶྠࡌ࡞ࡢ࡛ࡍࡀࠊ୍㒊ࡢඛ⏕ࡢ୰࡟ࡣ⊂❧ᛶࢆ⤯ᑐ࡟ᢸಖࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸࡜࠸࠺ពぢࡀ࡜࡚ࡶᙉ࠸ࡢ࡛ࡍࠋ⊂❧ᛶ࡜࠸࠺ྡࡢୗ࡟ࠊ࡜࡟࠿ࡃࢫ࣮࣌ࢫࢆ࠶ࡆ࡚ࠊࢸࢡࢽ࢝ࣝࢫࢱࢵࣇࢆ௜ࡅ࡚ࠊ࣏ࢫࢻࢡࡶ㸯ேࡎࡘ௜ࡅࡿࡢ࡛ࠊ
ࠕ⏝ពࢻ࡛ࣥࠖࡸࢀ࡜ゝࢃࢀ࡚࠸ࡿࡇ࡜ࡀከ࠸ࡢ࡛ࡍࡡࠋ
 ࡛ࡶࠊࡑ࠺࡞ࡿ࡜ࠊࡸࡣࡾ࿘ࡾࡀ┒ࡾୖࡆࡿ࡜࠸࠺࠿ࠊࣇ࢛࣮࣐ࣝ࡞ព࿡࡛ࡶ࣓ࣥࢱ࣮࡜
࠸ࡗࡓࡶࡢࡣࠊ⚾ࡢពぢ࡜ࡋ࡚ࡶ⤯ᑐ࡟ࡑࢀࡣᚲせࡔ࡜ᛮ࠸ࡲࡍࠋཱྀࢆฟࡋ࡚ࡣ࠸ࡅ࡞࠸࡜
࠸࠺㠀ᖖ࡟ᙉ࠸ពぢࡢඛ⏕ࡓࡕࡀ࠺ࡕࡢ኱Ꮫ࡟ࡣ࠸࡚ࠊ
ࠕ⊂❧࡞ࡢࡔ࠿ࡽࠖ࡜࠾ࡗࡋࡷࡿࡢ࡛
ࡍࠋࡋ࠿ࡋࠊᖺ㱋࡜࠸࠺ࡼࡾࡶࠊࡕࡻ࠺࡝࣏ࢫࢻࢡࡀ⤊ࢃࡗࡓࡇࢁࡢ࢟ࣕࣜ࢔ࡢேࡓࡕࡀࠊ
ࣛ࣎ࡢ㐠Ⴀࡶྵࡵ࡚ࠊ㐠Ⴀࢆ࡝࠺ࡸࡗ࡚࠸ࡃ࠿ࠊ኱Ꮫ㝔⏕ࢆ࡝࠺ࡸࡗ࡚ᣦᑟࡋ࡚࠸ࡃ࠿ࠊ࠿
ࡘ⮬ศࡢ◊✲ᐊ࡜ࡋ࡚ࡢⰍࢆฟࡋ࡚◊✲ࡢ᪉ྥᛶࢆỴࡵ࡚࠸ࡃ࠿ࠊㄽᩥࡶࡕࡷࢇ࡜᭩࠸࡚࠸
ࡃ࠿࡜࠸࠺ࡓࡵ࡟ࡣࠊ⚾ࡣ⮬ศࡢయ㦂ࢆྵࡵ࡚ࠊࡸࡣࡾ࠸ࢁ࠸ࢁ࡞ඛ⏕࠿ࡽࡢ࠸ࢁ࠸ࢁ࡞࢔
ࢻࣂ࢖ࢫࡣࠊᙧᘧࡣู࡜ࡋ࡚⤯ᑐ࡟ᚲせࡔ࡜ᛮ࠸ࡲࡍࠋ ≉࡟◊✲ᡤࡣࣘࢽࢵࢺࡀᑠࡉ࠸࡜࠾⪺ࡁࡋ࡚࠸ࡿࡢ࡛ࠊవィ࡟ࡑ࠺࠸࠺ࡇ࡜ࡀ࡞࠸࡜࠸ࡅ
࡞࠸ࠋࡑ࠺࠸࠺࣏ࢪࢩࣙࣥ࡟ࡘ࠸࡚࠸ࡿ᪉ࡓࡕࡣࠊࡇࢀ࠿ࡽࡢ᪉ࡓࡕ࡛ࡍࡼࡡࠋࡑࢀࡀࡘࡪ
ࢀ࡚ࡋࡲࡗ࡚ࡣඖࡶᏊࡶ࡞࠸ࡢ࡛ࠊࡑࡢ㎶ࡢయไࡀ࡛ࡁࡓࡽ࡜࠸࠺ࡢࡣᖖࠎᛮࡗ࡚࠾ࡾࡲࡍ
ࡀࠊ࠸࠿ࡀ࡛ࡋࡻ࠺࠿ࠋ
㸦ᒣᮏ㸧 ࡕࡻࡗ࡜ヰࡀ㣕ࢇ࡛ࡋࡲ࠺࠿ࡶࡋࢀࡲࡏࢇࡀࠊ⌧ᅾࠊዪᛶ࡟㝈ࡗࡓ෸ᩍᤵࡢබເ
ࢆࡸࡗ࡚࠸࡚ࠊࡑࡇࡢே஦࡟㛵ࡍࡿ㆟ㄽ࡛ࡣࠊ๭ྜᛮ࠸ษࡗࡓே஦ࢆࡍࡿࡢ࡛࠶ࢀࡤࠊ࣓ࣥ

− 58 −

ࢱ࣮ࡢ᪉ࢆ௜ࡅࡿ࡜࠿ࠊࡑ࠺࠸࠺㓄៖ࡀᚲせ࡛ࡣ࡞࠸࠿࡜࠸࠺㆟ㄽࡣ㐍ࢇ࡛࠸ࡿࡢ࡛ࡍࠋ ࡓࡔࠊ᪤࡟ᡤ࡟࠾ࡽࢀࡿ᪉ࠎ࡟ࡘ࠸࡚ࡣࠊࡲࡔ࣓ࣥࢱ࣮ࡀᚲせ࡞ࡢ࠿ࡢࡼ࠺࡞ᙧ࡟࡞ࡿ࡜
㏫࡟ኻ♩࡜࠸࠺ࡇ࡜ࡶ࠶ࡿࡢ࠿ࡶࡋࢀ࡞࠸ࡅࢀ࡝ࠊ௒࠾ヰࡀ࠶ࡗࡓࡼ࠺࡟ࠊࢫ࣮࣌ࢫ࡜ຓᩍ
࠶ࡿ࠸ࡣ NIBB ࣇ࢙࣮ࣟ࡜࠸࠺ࢩࢽ࢔࡞࣏ࢫࢻࢡࢆ௜ࡅ࡚ࠊ࠶࡜ࡣ⮬๓࡛ࡸࡗ࡚ࡃࡔࡉ࠸࡜
࠸࠺ࡇ࡜࡛ࠊࡑࡢࡲࡲ࡟࡞ࡗ࡚࠸ࡿ࡜࠸࠺ࡢࡀከศ஦ᐇࡔ࡜ᛮ࠺ࡢ࡛ࡍࡡࠋࡇࢀ࠿ࡽࡣ࣓ࣥ
ࢱ࣮࡜࠸࠺࠿┦ㄯᙺࡢࡼ࠺࡞ࡶࡢࢆࢃࢀࢃࢀࡶ┿๢࡟⪃࠼࡚࠸࠿࡞࠸࡜࠸ࡅ࡞࠸࡜ᛮ࠸ࡲࡍࠋ
 ࢔࣓ࣜ࢝࡞࡝ࡔࡗࡓࡽࠊࡑ࠺࠸࠺Ṕྐࡀ࠶ࡿࡢ࠿ࡶࡋࢀ࡞࠸࡛ࡍࡀࠊ᪥ᮏࡔ࡜࠸ࢁ࠸ࢁே
㛫㛵ಀࡀ」㞧࡟࡞ࡗ࡚ࠊ࠶ࡿ࡜ࡇࢁࡢ㆟ㄽ࡛ฟ࡚ࡁࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊ࣓ࣥࢱ࣮࡜࠸࠺ࡢࡣ
ࡑࡢୗࡢேࡀฟࡍㄽᩥ࡟ྡ๓ࢆධࢀ࡚ࡣ࠸ࡅ࡞࠸࡜࠸࠺ㄝࡀ࠶ࡾࡲࡍࠋ
㸦᳃㸧 ࣓ࣥࢱ࣮ࡣྡ๓ࢆධࢀ࡞࠸ࢇ࡛ࡍࡼࡡࠊᙜ↛ࠋ㸦ᒣᮏ㸧 ධࢀ࡚ࡣ࠸ࡅ࡞࠸࡜࠸࠺ࡢࡀཎ๎ࡔࡅ࡝ࠊࡔࢇࡔࢇኚࢃࡗ࡚ࡃࡿࢣ࣮ࢫࡀ࠶ࡿ࡜࠸࠺ࠋ㸦᳃㸧 ࡑ࠺࡞ࡢ࡛ࡍ࠿ࠋ
㸦ᒣᮏ㸧 ࡑ࠺࠸࠺ࡼ࠺࡞࡜ࡇࢁࡶ࠶ࡿࡼ࠺࡛ࡍࠋ㸦すᮧ㸧 ி኱ࡢⓑ┱ࣉࣟࢪ࢙ࢡࢺ࡞࡝ࡣࠊࡑࢇ࡞ཎ๎࡛ື࠿ࡋ࡚࠸ࡲࡍࡡࠋ
㸦ᒣᮏ㸧 ࡞ࡿ࡯࡝ࠋࡑ࠺࠸࠺࣮ࣝࣝࡀᚭᗏࡋ࡚ࡁ࡚ࠊࡁࡕࢇ࡜ࡸࢀࡿࡼ࠺࡟࡞ࢀࡤⰋ࠸ࡢ
࡛ࡍࡀࠊࡑ࠺࡛࡞࠸࡜ࠊ࣓ࣥࢱ࣮ࡀࡑࡢ࠺ࡕࡑࡇࢆ⮬ศࡢࢸࣜࢺ࣮ࣜ࡟ࡋ࡚ࡋࡲ࠺࡜࠸ࡗࡓ
࠾ࡑࢀࡶ࠶ࡿࡼ࠺࡛ࡍࠋ
㸦᳃㸧 ࠶࠶ࠋ
㸦Ⲩᮌ㸧 㑇ఏ◊ࡣࢸࢽࣗ࢔ไࢆࡸࡿ࡜ࡁ࡟௒ࡣ࣓ࣥࢱ࣮ࢆ௜ࡅ࡚࠸ࡲࡍࠋ௒ࡢேࡓࡕࡣ㸲ᮇ࡛ࠊ௒ᗘࡣ㸳ᮇ┠࡞ࡢ࡛ࡍࡀࠊ㐣ཤࡢ⤒㦂࠿ࡽゝࡗ࡚ࠊ᭱ึࡣ௜ࡅ࡞࠿ࡗࡓࡢ࡛ࡍࡀࠊࡸ
ࡣࡾ௜ࡅࡓ᪉ࡀ࠸࠸࡜࠸࠺ࡇ࡜࡛௒ࡣ௜ࡅ࡚࠸ࡲࡍࠋࡶࡕࢁࢇㄽᩥ࡟ྡ๓ࡣධࡾࡲࡏࢇࡀࠊ
ࡸࡣࡾ࣓ࣥࢱ࣮ࡢ᪉ࡀ࠸࡚ࠊ࠶ࡿ⛬ᗘࢧࢪ࢙ࢫࢳࣙࣥࡍࡿࠊẼ㍍࡟⪺ࡁ࡟᮶ࡽࢀࡿேࡀ࠸ࡿ
࡜㝶ศ㐪࠺ࡼ࠺࡛ࡍࠋ≉࡟ⱝ࠸ே࡛ࡍ࡜ࠊ⮬ศ࡛ㄽᩥࢆ࠶ࡲࡾ᭩࠸ࡓࡇ࡜ࡀ࡞࠸ࡇ࡜ࡉ࠼࠶
ࡿࡢ࡛ࠊ᭱ึࡣᑡࡋぢ࡚࠶ࡆࡿ࡜㝶ศ㐪࠸ࡲࡍࡡࠋ
 ㉁ၥ࡞ࡢ࡛ࡍࡀࠊඛ࡯࡝ࡢዪᛶࡢ᪉ࢆ᥇ࡽࢀࡿ࡟ࡋ࡚ࡶࠊࡸࡣࡾࡑࢀࡣ෸ᩍᤵṆࡲࡾ࡞ࡢ࡛ࡍ࠿ࠋ෸ᩍᤵࢆ᥇ࡽࢀ࡚ࠊ᪼௵ࡣ඲ࡃ⪃࠼࡞࠸࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍ࠿ࠋ
㸦᳃㸧 ᪼᱁࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦ᒣᮏ㸧 ࠸ࡸࠊࡑࡇࡲ࡛ࡁࡕࢇ࡜㆟ㄽࡋ࡚࠸ࡿࢃࡅ࡛ࡣ࠶ࡾࡲࡏࢇࠋ⚾ࡶࡇࢀࡲ࡛୙ᩥᚊ

− 59 −

ⓗ࡟ࡑ࠺࡞ࡗ࡚࠸ࡿࡢࡣ▱ࡗ࡚࠸ࡲࡍࡀࠊࡕࡷࢇ࡜⏦ࡋྜࢃࡏࢆࡋ࡚࠸ࡿࡢ࡛ࡍ࠿ࠋ㸦すᮧ㸧 ⏦ࡋྜࢃࡏࡣࡋ࡚࠸࡞࠸࡛ࡍࡡࠋᒸᓮ୕ᶵ㛵࡜ࡋ࡚ࡣᇶᮏⓗ࡟᪼௵ே஦ࡣࡋ࡞࠸
࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍࡀࠊ౛࠼ࡤ⏕⌮◊ࡢ౛࡛ࡍ࡜ࠊ⏕⌮◊࠿ࡽ⤫ྜࣂ࢖࢜࡟෸ᩍᤵࡢேࡀᩍ
ᤵ࡛⛣ࡗࡓࡾ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡣ⾜ࡗ࡚࠾ࡾࡲࡍࡋࠊࡦ࡜ࡘࡢ㒊㛛ࡢ෸ᩍᤵࡢேࡀࡑࡢࡲࡲ
ᩍᤵ࡟ୖࡀࡿ࡜࠸࠺ࡢࡣ࠶ࡲࡾᮃࡲࢀ࡞࠸࡜࠸࠺ࡇ࡜࡛ࡍࠋࡑ࠺࠸࠺ព࿡ྜ࠸࡛ࡍࡢ࡛ࠊ௒
ࡢࡼ࠺࡞ᙧࡢ⊂❧ࡢ࡜ࡇࢁࡀ࡛ࡁࡓ࡜ࡁ࡟⊂❧෸ᩍᤵࡀḟ࡟᪂ࡋ࠸㒊㛛ࡢᩍᤵ࡟࡞ࡿ࡜࠿ࠊ
ࡑ࠺࠸࠺ࡇ࡜࡟㛵ࡋ࡚ࡣࠊᚲࡎࡋࡶ࡛ࡁ࡞࠸࡜࠸࠺ࡼ࠺࡞ᙧ࡛㐍ࡵࡽࢀ࡚࠸ࡿࢃࡅ࡛ࡣ࡞࠸࡛ࡍࠋ㸦Ⲩᮌ㸧 ⊂❧ࡢ෸ᩍᤵ࡛᥇ࡽࢀࡓே࡜࠸࠺ࡢࡣ࢖ࣥࢭࣥࢸ࢕ࣈࡀ࡞ࡃ࡞ࡾࡲࡍࡼࡡࠋࡎࡗ
࡜෸ᩍᤵ࡛ࠊฟࡿࡋ࠿࡞࠸࡜࠸࠺ࡇ࡜ࡔ࡜ࠊ࠸࠸௙஦ࢆࡋ࡚ᩍᤵ࡟࡞ࡿ࡜࠸࠺ࡇ࡜ࡣࡶ࠺ࡑ
ࡢᶵ㛵࡛ࡣ࡞࠸ࠋࡔ࠿ࡽࠊ኱ࡁ࡞ࢳ࣮࣒࡛ࡸࡗ࡚࠸ࡿ࡜ࡁ࡟࣎ࢫࡀ࠸࡚ࠊࡑࡢḟࡢேࡀୖࡀ
ࡿ࡜࠸࠺ࡇ࡜ࡣ࡞࠸࡜࠸࠺ࡢࡣศ࠿ࡿࡢ࡛ࡍࡀࠊ᭱ึ࠿ࡽ⊂❧ࡢ෸ᩍᤵ࡛᮶ࡓ᪉ࡀࠕࡶ࠺ᩍ
ᤵࡣ࡞࠸ࠖ࡜ゝࢃࢀࡿ࡜⤖ᵓࡁࡘ࠸ࡢ࡛ࡣ࡞࠸࡛ࡋࡻ࠺࠿ࠋࡇࡢ෸ᩍᤵࡢ࣏ࢪࢩࣙࣥࢆࢸࢽ
ࣗ࢔ࡳࡓ࠸࡟ᢅࢃࢀࡓࡽࠊࢸࢽࣗ࢔ࢺࣛࢵࢡ࡛ᩍᤵ࡟࡞ࡿ࠿࡜࠸࠺ࡼ࠺࡞ᙧ࡛ᢅ࠼ࡿ࡜ᛮ࠺ࡢ࡛ࡍࠋ㸦すᮧ㸧 ࡲࡔᇶ⏕◊ࡣࢸࢽࣗ࢔ࢺࣛࢵࢡࡢࢩࢫࢸ࣒ࡣᐇ㝿࡟ࡣᑟධࡋ࡚࠸࡞ࡃ࡚ࠊࡑࢀࡣ
ᩍᤵ఍➼࡛࠿࡞ࡾ㆟ㄽࡣࡋࡓࡢ࡛ࡍࡀࠊࡸࡣࡾ௒ࡢࢩࢫࢸ࣒ࡢ୰࡛ࢸࢽࣗ࢔ࢆࡍࡄ࡟ᑟධࡍ
ࡿࡢࡣ࡞࠿࡞࠿㞴ࡋ࠸࡜࠸࠺㆟ㄽ࡛Ṇࡲࡗ࡚࠸ࡿ≧ែ࡛ࡍࠋ
㸦ྜྷ⏣㸧 ⚾ࡣ୺ᖿࢆ௮ࡏࡘ࠿ࡗ࡚ࡇࡇ࡟ᗙࡗ࡚ࡣ࠸ࡿࡢ࡛ࡍࡀࠊ㸳ᖺ๓࡟ᇶ⏕◊࡟᥇ࡗ࡚࠸ࡓࡔ࠸࡚ࠊࡑࡢ࡜ࡁ࡟ึࡵ࡚ᩍᤵ࡜ࡋ࡚ࣛ࣎ࢆᣢࡗ࡚ࠊ࠾ヰࡢ෸ᩍᤵ࡜ྠࡌ≧ἣࡔࡗࡓ࡜
ᛮࡗ࡚࠸ࡲࡍࠋሷぢඛ⏕ࡢ࠾ࡗࡋࡷࡿࡼ࠺࡟⤖ᵓⱞࡋ࠸≧ἣ࡛࠶ࡗࡓ࡜ᛮ࠸ࡲࡍࠋሙᡤ࡜ே
࡜ࢆᮏᙜ࡟ࣇࣝ࡟㡬࠸࡚ࠊࡑࢀࡣᜨࡲࢀ࡚࠸ࡓࡢ࡛ࡍࡀࠊࡑࡢ୍᪉࡛ࠊᐇࡣࠕࡉ࠶ࠊ࡝࠺ࡋ
ࡓࡽ࠸࠸ࡢࡔࠖ࡜㏵᪉࡟ᬽࢀࡿ࡜࠸࠺ឤぬࡀ࠶ࡗࡓࡢࢆぬ࠼࡚࠸ࡲࡍࠋ ⚾ࡢሙྜࡣࠊࡑࡇ࡟࠸ࡽࡗࡋࡷࡿᑠᯘඛ⏕ࡀᐇ㝿࡟ࣛ࣎ࡶࡍࡄ㏆ࡃ࡛ࡋࡓࡋࠊ◊✲ࡢෆᐜࡶ㏆ࡃ࡚ࠊ᪂Ꮫ⾡ࡶ୍⥴࡟ࡸࡽࡏ࡚࠸ࡓࡔ࠸࡚ࠊᖾ㐠ࡀ㔜࡞ࡗ࡚ࠊᑠᯘඛ⏕ࡣྰᐃࡉࢀࡿ࠿
ࡶࡋࢀࡲࡏࢇࡀࠊ࣓ࣥࢱ࣮࡜࠸࠺ࡘࡶࡾ࡛ᙇࡾ௜࠿ࡏ࡚࠸ࡓࡔ࠸࡚ࠊఱ࠿ࡢࡓࡧ࡟ហ⑵ࢆゝࢃࡏ࡚࠸ࡓࡔ࠸ࡓࡾࠊࢧ࣏࣮ࢺࡋ࡚࠸ࡓࡔ࠸ࡓࡾࡋࡲࡋࡓࠋࡑࢀࡀ࠶ࡗ࡚ࠊ⮬ศ࡛ࡣ‶㊊࡞
ࡇ࡜ࡣ࡛ࡁ࡚࠸ࡿ࡜ࡣᛮࡗ࡚࠸࡞࠸ࡢ࡛ࡍࡀࠊఱ࡜࠿ࡸࢀ࡚࠸ࡓ࡜࠸࠺ࡢࡀᮏᙜ࡟࠶ࡗࡓ࡜
ᛮ࠸ࡲࡍࠋ ไᗘ࡜ࡋ࡚࣓ࣥࢱ࣮࡜࠸࠺᪉ࢆ⨨ࡃࡇ࡜ࡀ࡝࠺࠿࡜࠸࠺ࡢࡣ☜࠿࡟࠸ࢁ࠸ࢁ࡞ၥ㢟ࡀ࠶ࡿ࠿ࡶࡋࢀࡲࡏࢇࡅࢀ࡝ࡶࠊ࡛ࡶࠊ࠶ࡗ࡚ࡶ࠸࠸࡜ᛮ࠺ࡋࠊࡑࢀࡼࡾࡶ⡆༢࡟࠾ヰࡋ࡛ࡁࡿ㞺ᅖẼ࡜࠸࠺࠿ࠊ࠾஫࠸࡟㞄ྠኈ࡛ࠕࡑࡢ௙஦ࡣ㠃ⓑ࠸ࡼࠖ࡜୍ゝゝࢃࢀࡿࡔࡅ࡛ᩆࢃࢀࡓࡾࠊ

− 60 −

ࡑࢇ࡞ࡼ࠺࡞ࡇ࡜࡞ࡢ࠿࡞࡜⚾ࡣᛮࡗ࡚࠸ࡲࡍࠋ࡛ࡍ࠿ࡽࠊ࠸ࢁ࠸ࢁ࡞ᙧ࡛࠾஫࠸ࡢ◊✲ࢆ▱ࡾྜࡗ࡚ࠊヰࡀ࡛ࡁ࡚ࠊ࡝ࡇ࠿࡛ヰࢆ⪺࠸ࡓࡽ▱ࡽࡏࡿ࡜࠿ࠊࡑ࠺࠸ࡗࡓࡕࡻࡗ࡜ࡋࡓ㛵ಀࡀ࠸ࢁ࠸ࢁ࡞௙᥃ࡅ࡛࡛ࡁ࡚࠸ࡃ࡜࠸࠸࡜ᖖࠎᛮࡗ࡚࠸ࡲࡍࠋᚲࡎࡋࡶ⡆༢࡛ࡣ࡞࠸࡛ࡍ
ࡀࠊᡤෆࡢࢭ࣑ࢼ࣮ࢆࡁࡗࡕࡾࡸࡾ࡞ࡀࡽࠊ࠾஫࠸ࡀࡸࡗ࡚࠸ࡿࡇ࡜ࢆ▱ࡿ࡜࠿ࠊ࠿࡞ࡾⲡ
ࡢ᰿ⓗ࡛ࡣ࠶ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀࡣ࠶ࡿ࠿࡞࡜ᛮ࠸ࡲࡍࠋ
ࡑ࠺࠸ࡗࡓࡇ࡜ࢆឤࡌࡲࡋࡓࠋ
㸦㛗㇂㸧 ௒ࡢࡈⓎゝࢆ⪺࠸ࡓࡽࠊࡲ
ࡉ࡟ࢧ࢖࢚ࣥࢸ࢕ࢫࢺ࡜ࡋ࡚ࡣࠊࡑ࠺
࠸࠺⎔ቃ࡛ࡸࡗ࡚࠸ࡅࡿ࡜࠸࠺ࡢࡣ኱
ኚᖾࡏ࡞ࡇ࡜ࡔࢁ࠺࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ㈨ᩱ㸱㸦3㸧࡟࠶ࡿࡼ࠺࡟ࠊᩍᤵ ࠊ෸ᩍᤵ ࠊຓᩍࠊ≉௵ࢆྵࡵ࡚  ࡜ࠊࡇࢀࡣࡲࡔᇙࡲࡗ࡚࠸࡞࠸ࡢ࡛ࡋࡻ࠺
࠿ࡽࠊࡉࡽ࡟ᐃဨࡀ௜࠸࡚࠸ࡿࡼ࠺࡟࠾ぢཷࡅࡋࡲࡍࠋ኱Ꮫࡢ௜⨨◊✲ᡤ࡞
࡝ࡣே௳㈝๐ῶࡢ୰࡛౛࠼ࡤ 㸣࣮ࣝࣝ࡜࠸࠺ࡼ࠺࡞ࡶࡢࡀㄢࡏࡽࢀ࡚ࠊ
ἲே໬ࡋࡓ࡜ࡁࡢᐃဨࢆࡉࡽ࡟ 㸣ῶࡽࡋ࡚ᑗ᮶஌ࡾษࡿ࡜࠸࠺ᙧ࡛ேဨ
⟶⌮⾜ࡗ࡚࠸ࡲࡍࠋ
 ࡑ࠺࠸࠺୰࡛㈨ᩱ㸱㸦3㸧ࡢ㓄⨨ࢆぢࡉࡏ࡚࠸ࡓࡔࡁࡲࡍ࡜ࠊ౛࠼ࡤከᵝᛶ⏕≀Ꮫ◊✲ᐊ࡟ࡓࡃࡉࢇࡢຓᩍࡢඛ⏕᪉ࡀ࠾ࡽࢀ࡚ࠊ࡞࠾࠿ࡘ PI ᩍᤵࡢୗ࡛ຓᩍࡶධࢀࡓᙧࡢࢢ࣮ࣝࣆ
ࣥࢢࡀ࡛ࡁࡿ࡜࠸࠺వ⿱ࡢ୰࡛ࡢ◊✲ᐊᵓᡂࡀぢ࡚ྲྀࢀࡿࢃࡅ࡛ࡍࠋᑗ᮶࡟ࢃࡓࡗ࡚ࡇ࠺࠸
࠺వ⿱ࢆᣢࡗࡓᙧ࡛⤌⧊ࡀ㐠Ⴀࡉࢀࡿࡢ࠿࡝࠺࠿ࠊඹྠ฼⏝ᶵ㛵ࡀูᯟ࡛࠶ࡿ࡜࠸࠺≀ࡢ⪃࠼᪉ࡣከศ࡞࠸ࡢࡔࢁ࠺࡜ᛮ࠺ࡢ࡛ࠊ⤌⧊࡜ࡋ࡚ࡣᑗ᮶ࢆぢᤣ࠼ࡓே஦㓄⨨ࠊᐃဨ⟶⌮ࢆ⪃࠼࡞࠸࡜࠸ࡅ࡞࠸࡜࠸࠺ࡢࡀ㸯Ⅼ࡛ࡍࠋ ࡑࢀ࡟ᑐࡋ࡚ࠊࡼࡃゝࢃࢀ࡚࠸ࡿࡢࡣ௵ᮇไࢆᑟධࡋࡓࡽ࡝࠺࠿࡜࠸࠺ࡼ࠺࡞ᙧ࡛ࡍࠋ௒
ࡣ࠶ࡲࡾゝࢃࢀ࡚࠸ࡲࡏࢇࡅࢀ࡝ࡶࠊ࠿࡞ࡾ኱Ꮫࡢ௜⨨◊➼ࡣ⋡ඛࡋ࡚௵ᮇไࢆᑟධࡋ࡚ࠊ
௒ࡣࡑࡢ௵ᮇไࡢ෌௵࠶ࡿ࠸ࡣ෌ࠎ௵ࡢ᫬ᮇ࡟ᙜࡓࡗ࡚኱ኚࡘࡽ࠸ᛮ࠸ࢆࡋ࡚࠸ࡿሙྜࡶ࠶
ࡾࡲࡍࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡀࡑ࠺࠸࠺኱Ꮫ௜⨨◊ࡢ௒ࡢ≧ἣࡶ㋃ࡲ࠼ࡘࡘࠊ࡞࠾࠿ࡘࡑ࠺࠸
࠺ࡶࡢࢆ㉸࠼࡚ᑗ᮶ࡢேဨ㓄⨨ࢆ⪃࠼࡞ࡅࢀࡤ࡞ࡽ࡞࠸࡜ᛮ࠸ࡲࡍࠋ⚾ࡣಶேⓗ࡟ࡣࠊ኱ኚ
Ⰻዲ࡞◊✲⎔ቃ࡛࠶ࢀࡤࠊேࡣఱ࡜࠿ࡑࡇ࡛ⴠࡕ╔࠸࡚ࠊዲࡁ࡞◊✲ࢆࡋ࡚࠸ࡃ࡜࠸࠺≀ࡢ⪃࠼᪉࡟㝗ࡾࡸࡍ࠸ࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊࡑ࠺࡛ࡣ࡞ࡃ࡚ࠊࡁࡕࢇ࡜ไᗘ࡜ࡋ࡚ඛࡣ࡞࠸࡜࠸
࠺ࡼ࠺࡞ỴࡲࡾࢆసࢀࡤࠊPI ࡶ㔜せ࡞ேࢆᡭᨺࡍດຊࡶࡍࡿࡋࠊ㏫࡟ⱝᡭࡢ᪉ࡣᇶ⏕◊ࢆ㋃
ࡳྎ࡟ࡋ࡚⮬ศࡢ࢟ࣕࣜ࢔ࣂࢫࢆ⮬ᕫ㈐௵࡛✚ࢇ࡛࠸ࡃ࡜࠸࠺ࡼ࠺࡞ᩥ໬ࡀ⏕ࡲࢀࡿࡔࢁ࠺

− 61 −

࡜ᛮ࠸ࡲࡍࠋ࣓ࣥࢱ࣮ไᗘࡔࡅ࡛඲࡚ࢆゎỴࡍࡿࡢࡣ࡜࡚ࡶ㞴ࡋ࠸ࡢ࡛ࡣ࡞࠿ࢁ࠺࠿࡜ᛮࡗ
࡚࠾ࡾࡲࡍࠋ
 ࡶ࠺୍ࡘゝࢃࡏ࡚࠸ࡓࡔࡁࡲࡍ࡜ࠊ෌௵࠶ࡾ࡜࠸࠺௵ᮇไ࡛ࠊࡓࡔࡋࠊ」ᩘᅇ෌௵ࡋ࡞࠸
࡜࠸࠺ࡇ࡜ࡀไᗘⓗ࡟ࡣ࠶ࡿࢃࡅ࡛ࡍࠋࢃࢀࢃࢀࡶࡑࢀࢆࡋࡓ࠸࡜ᛮ࠺஦౛ࡀࡓࡃࡉࢇฟ࡚
ࡁ࡚࠸ࡿࢃࡅ࡛ࡍࡀࠊ෌௵࠶ࡾࡔࡅࢀ࡝ࡶࠊ㸰ᅇ┠ࡔ࠿ࡽ௵ᮇࢆ᭦᪂ࡋ࡞࠸࡜࠸࠺ࡼ࠺࡞஦
౛ࡣࠊㄪ࡭ࡓ࡜ࡇࢁ᪥ᮏ࡛ࡣ㸰౛ࡋ࠿࡞࠸ࡢ࡛ࡍࡡࠋ࡜࠸࠺ࡇ࡜ࡣ࡝࠺࠸࠺ࡇ࡜࠿࡜࠸࠸ࡲ
ࡍ࡜ࠊ෌௵㸯ᅇ㝈ࡾࡢ௵ᮇไ࡛࠶ࢀࡤ㐠⏝ࡋࡸࡍ࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ୧⪅༠㆟ࡢୖ࡛෌௵ࢆ
ࡋ࡞࠸ሙྜ࡜࡞ࡿ࡜ࠊ⤖ᒁࡣ෌௵࡟࡞ࡗ࡚ࡋࡲ࠺ࡢ࡛ࡍࠋࡔ࠿ࡽࠊࡑ࠺࠸࠺ព࿡࡛ࡁࡗࡕࡾ
ࡋࡓ௵ᮇไࢆᑟධࡉࢀࡿ࡜࠸࠺ࡢࡀ୍ࡘࡔࢁ࠺࡜ᛮ࠸ࡲࡍࠋ
㸦㔝⏣㸧 ᇶ⏕◊ࡶ࠸ࢃࡺࡿἲே໬ࢆᮇࡋ࡚ࠊ࠶ࡿ࠸ࡣࡑࡢᑡࡋ๓࠿ࡽ࡛ࡋࡻ࠺࠿ࠊຓᩍࡣ
㸳ᖺࣉࣛࢫ㸰ᖺࠊ෸ᩍᤵࡣ㸳ᖺࣉࣛࢫ㸳ᖺ࡜࠸࠺ไᗘ࡛ࡸࡗ࡚࠾ࡾࡲࡍࠋࡓࡔࠊࡑࡢᚋࠊ㸰ᖺ࠾ࡁࡢ෌௵ࢆᑂᰝࢆ⤒࡚ㄆࡵࡿ࡜࠸࠺ᙧ࡛㐍ࡵ࡚࠾ࡾࡲࡍࠋඛ⏕ࡢ࠾ࡗࡋࡷࡿ࡜࠾ࡾࠊ෌
௵೵Ṇ࡜࠸࠺ࡇ࡜࡟࡞ࡗࡓேࡣ௒ࡢ࡜ࡇࢁ࠸࡞࠸ࡢ࡛ࠊ᪩࠸ேࡣ෌௵㸰ᖺࢆ」ᩘᅇ⥆ࡅ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡀࡈࡊ࠸ࡲࡍࠋ ࡓࡔࡋࠊࡇࡢ◊✲ᡤࡣ㒊㛛ࡢ㛗ࡀᐃᖺ࡟࡞ࡗࡓሙྜࡣࠊࡑࡢࣛ࣎ࡣ࡞ࡃ࡞ࡿ࡜࠸࠺࣮ࣝࣝ
࡟࡞ࡗ࡚࠾ࡾࡲࡍࡢ࡛ࠊ㒊㛛࡟ᒓࡋ࡚࠸ࡿຓᩍࠊ෸ᩍᤵ࡟ࡘࡁࡲࡋ࡚ࡣࠊ㒊㛛ࡀ㛢㙐ࡍࡿ࡜ࡁ࡟ࠊࡑࢀ௨ୖࡢ௵ᮇ᭦᪂ࡣ࠶ࡾࡲࡏࢇࠋ௒ࠊఱே࠿ࡢຓᩍ࠶ࡿ࠸ࡣ෸ᩍᤵࡶྵࡵ࡚ṧࡗ࡚࠸ࡿඛ⏕᪉ࡣࠊ࠸ࢃࡺࡿᐃᖺไ࡛ࠊ௵ᮇไࢆᩜࡃ๓ࡢ㞠⏝ࡢேࡓࡕ࡛ࡍࠋ㒊㛛ࡀ࡞ࡃ࡞ࡗ࡚
ࡶࠊࡑࡇ࡛ࡶࡗ࡚㏥⫋࡜࠸࠺ࡇ࡜࡟ࡣ࡞ࡗ࡚࠸࡞࠸㞠⏝ไᗘࡢࡶ࡜࡛᥇⏝ࡉࢀࡓேࡓࡕࡀᑿ
ࢆᘬ࠸࡚࠸ࡿ㒊ศࡀ࠶ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ
㸦㛗㇂㸧 ࡝࠺ࡋ࡚ࡶ PI ࡢ❧ሙ࡛ࡑ࠺࠸࠺᪉ࠎࡢ㞠⏝ࢆ⪃࠼ࡿሙྜ࡜ࠊᙜ஦⪅ഃࡢ⪃࠼᪉ࡀඹᏑࡍࡿ୰࡛ࠊຓᩍ࡛࢟ࣕࣜ࢔ࢆ✚ࢇ࡛࠸࠿ࢀ࡚౛࠼ࡤᩍᤵ࡛㌿௵ࡉࢀࡼ࠺࡜ࡍࡿ࡜ࡁ࡟ࡣࠊ
ㅮᖌ࠶ࡿ࠸ࡣ෸ᩍᤵ࡟᪼௵ࡋࡓᙧ࡛ࢫࢸࢵࣉ࢔ࢵࣉࡋ࡚࠸ࡃ࡜࠸࠺ࡼ࠺࡞ᡓ␎ⓗ࡞౑࠸᪉ࡶࡍࡿᚲせࡀ࠶ࡿࢃࡅ࡛ࡍࠋࡑࡢ࡜ࡁ࡟᭱㏆ࡼࡃྲྀࡽࢀࡿࡢࡣࠊ௵ᮇἲࡢ௵ᮇไ࡜ປᇶἲࡢ௵
ᮇไࢆ౑࠸ศࡅࡿࡇ࡜࡛ࡍࠋࡈᏑࡌࡔ࡜ᛮ࠸ࡲࡍࡀࠊࢃࢀࢃࢀࡣ௵ᮇἲ࡛࡯࡜ࢇ࡝㐠⏝ࡋ࡚࠸ࡲࡍࡀࠊປᇶἲ࡛௵ᮇࢆ௜ࡅ࡚ࡶ඲ࡃၥ㢟࡞࠸ࢃࡅ࡛ࡍࠋ ࡛ࡍ࠿ࡽࠊ࢟ࣕࣜ࢔࢔ࢵࣉࡢࡓࡵࡢ᪼௵ࡢ࣏ࢪࢩࣙࣥࡣປᇶἲࡢ௵ᮇไ࡜ࡋ࡚ࠊࡇࢀ࡛㸳ᖺ௨ෆ࡛࠶ࢀࡤ⮬⏤࡟௵ᮇࢆ௜ࡅࡽࢀࡲࡍࡢ࡛ࠊ௵ᮇࢆ㸰ᖺ࠶ࡿ࠸ࡣ㸱ᖺ࡜ࡋ࡚ࡑࡇ࡛ᚲࡎ
෌௵࡞ࡋ࡜࠸࠺ປാዎ⣙࡟ࡍࢀࡤ⤌⧊࡜ࡋ࡚ࡑࡢேࡢ࢟ࣕࣜ࢔ࣃࢫ࡟≉ẁࡢ㓄៖ࢆࡋࡓୖ࡛
ᐃဨ㐠⏝ࡋ࡚࠸ࡅࡿ࡜࠸࠺௙⤌ࡳࡀ࠶ࡾࡲࡍࡡࠋ㸦すᮧ㸧 ࡑࢀࢆ⺮ⓑ◊࡛ࡣࡸࡗ࡚࠾ࡽࢀࡿ࡜ࠋ
㸦㛗㇂㸧 ⺮ⓑ◊ࡣ௒ࡸࢁ࠺࡜ࡋ࡚࠸ࡿࢃࡅ࡛ࡍࠋ௚ࡢ◊✲ᡤ࡛ࡣࡸࡗ࡚࠸ࡿ࡜ࡇࢁࡣࡓࡃ

− 62 −

ࡉࢇ࠶ࡾࡲࡍࠋࡑࢀࡀ࠸ࢃࡺࡿᚋࢁྥࡁ࡛ࡣ࡞ࡃ࡚ࠊ⤌⧊࡜ࡋ࡚ᵓᡂဨࡢ࢟ࣕࣜ࢔࢔ࢵࣉࢆ
ᛂ᥼ࡍࡿࡓࡵࡢࡶࡢ࡜ࡋ࡚ື࠿ࡏࡤࠊヱᙜࡍࡿேࡶ኱ኚࣔࢳ࣮࣋ࢩࣙࣥࡀୖࡀࡿࢃࡅ࡛ࡍࠋ ࡔ࠿ࡽࠊᇶ⏕◊࡜ࡋ࡚ࢃࢀࢃࢀ࠿ࡽぢࡓ࡜ࡁ࡟ேࡢά⏝ࡢ㞮ᙧ࡟࡞ࡿࡼ࠺࡞ືࡁࢆぢࡏ࡚࠸ࡓࡔࡁࡓ࠸࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ௒ࡢ࠾ヰࢆ⪺࠸࡚࠸ࡓࡽࠊࢃࢀࢃࢀࡢ᪥ᖖࡢ㆟ㄽ࡜࠶ࡲࡾ኱
ᕪࡢ࡞࠸ᙧ࡛ᐃဨ⟶⌮ࢆࡸࡗ࡚࠾ࡽࢀࡿࡼ࠺࡛ࡍࡢ࡛ࠋ
㸦ᒣᮏ㸧 వ⿱ࡀ࠶ࡿ࠿ࡽࡇ࠺࠸࠺ຓᩍࡢ᪉ࡀ࠸ࡿ࡜࠸࠺ࢃࡅ࡛ࡣ࡞ࡃ࡚ࠊ௒ゝࡗࡓࡼ࠺࡞
஦᝟࡛ࡍࠋࡴࡋࢁᮏᙜࡣࡇ࠺࠸࠺᪉ࠎࡢ࣏ࢪࢩࣙࣥࢆࡶ࠺ᑡࡋ᭷ຠά⏝࡛ࡁࢀࡤࠊ඲య࡜ࡋ
࡚◊✲ᡤࡢάຊࡀୖࡀࡿ࡜࠸࠺ࡇ࡜ࡣ⪃࠼࡚࠸ࡿࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊ࡞࠿࡞࠿ಶู࡟㞴ࡋ࠸ၥ㢟ࢆᢪ࠼࡚࠾ࡽࢀࠊ௒࠾ࡗࡋࡷࡗࡓࡼ࠺࡞ᙧ࡛᪼௵ࡋ࡚௵ᮇࢆ௜ࡅࡿ࡜࠸࠺ࡇ࡜ࡀ࡛ࡁࡿ
࠿࡝࠺࠿୙࡛᫂ࡍࠋ᪼௵ࡋ࡞ࡃ࡚ࡶᐃᖺࡲ࡛࠸ࡽࢀࡿ᪉ࡀ࠸࠸࡜࠸࠺࠾⪃࠼࡟ᅛᇳࡉࢀ࡚ࡋ
ࡲ࠼ࡤࠊࡶ࠺ࡑࢀࡣࡑࢀ࡛ື࠿ࡏ࡞࠸࡜࠸࠺ࡇ࡜࡟࡞ࡗ࡚ࡋࡲ࠺ࡢ࡛ࠋ࠶ࡿព࿡࡛ࡣ኱ኚࢿ
࢞ࢸ࢕ࣈ࡞᪉ྥ࠿ࡽぢ࡚ࠊ࠸ࢁ࠸ࢁࢧࢪ࢙ࢫࢳࣙࣥࢆ㡬࠸࡚࠸ࡿ࡜ᛮ࠺ࡢ࡛ࡍࡅࢀ࡝ࡶࠊၥ
㢟࡜ࡋ࡚⪃࠼ࢁ࡜࠸࠺ࡇ࡜࡛ཷࡅṆࡵࡓ࠸࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ௵ᮇไ࡜ࡋ࡚ࡢၥ㢟ࢆ⪃࠼ࡿ࡜࠿ࠊ࣓ࣥࢱ࣮ไ
ᗘࢆά⏝ࡍࡿ࡜࠸࠺ࡢࡣ㠀ᖖ࡟㔜せ࡛ࠊ⚾࡝ࡶࡣࡲࡔ࠶ࡲࡾ᳨ウࡋ࡚࠾ࡾࡲࡏࢇ࡛ࡋࡓࡢ࡛ࠊ
ࡑ࠺࠸࠺Ⅼࢆྵࡵ᳨࡚ウࡉࡏ࡚࠸ࡓࡔࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ
㸦᳃㸧 ࡍࡳࡲࡏࢇࠋ௒ࡢ࠾ヰ࡛ࠊ⚾ࡀヰࡋࡓࡢࡣ෸ᩍᤵࠊPI ࡢ࠾ヰ࡛ࡍࠋ㸦すᮧ㸧 PI ࡛ࡍࡡࠋ
㸦᳃㸧 㛗㇂ඛ⏕ࡀ࠾ࡗࡋࡷࡗࡓࡢࡣ࣭࣭࣭ࠋ㸦すᮧ㸧 ඛ⏕ࡣࡶࡗ࡜඲య࡛ࡍࡡࠋ
㸦᳃㸧 ඲య࡛ࡍࡼࡡࠋ౛࠼ࡤᐇ㝿࡟ࡣᩍᤵࡢඛ⏕ࡀ࠸࡚ࠊྠࡌ◊✲ᐊ࡛ࡶຓᩍ࡜ࡋ࡚࣏ࢪ
ࢩࣙࣥࡀ࠶ࡿ࡜࠸࠺᪉ࡶྵࡵ࡚ࡢ࠾ヰ࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡣ࠸ࠋ㸦᳃㸧 ศ࠿ࡾࡲࡋࡓࠋ
㸦ᒣᮏ㸧 ࡔ࠿ࡽࠊ඲య࡜ࡋ࡚ࡣࠊ᪂᥇⏝ࡢຓᩍࡢ᪉࡞࡝ࡣ௵ᮇࡀ௜࠸࡚࠸ࡿᙧ࡟࡞ࡗ࡚࠸
ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀ௨๓ࡢ᫬௦ࡢ᪉ࡀṧࡗ࡚࠸ࡿⅬ࡟ࠊ࡞࠿࡞࠿ᡭࡢ௜ࡅࡼ࠺ࡀ࡞࠸࡜
ࡇࢁࡀ࠶ࡿ࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍࠋ
㸦᳃㸧 ࡑࢀࡣ኱Ꮫࡶྠࡌၥ㢟࡞ࡢ࡛ࡍࠋ
− 63 −

㸦㔝⏣㸧 ୍ࡘࡔࡅ≉Ṧ஦᝟ࡣࠊ෸ᩍᤵ௨ୖࡢே஦ࡣ㐠Ⴀ఍㆟ࡢᢎㄆࡀせࡿࢃࡅ࡛ࡍࡡࠋ࡛
ࡍ࠿ࡽࠊ㛗㇂ඛ⏕ࡢࡈᥦ᱌ࡉࢀࡓࡼ࠺࡟ࠊຓᩍࡢ᪉ࢆ෸ᩍᤵ࡟ୖࡆ࡚ࠊ࡛ࡁࡿࡔࡅእ㒊࡟ฟ࡚⾜࠿ࢀࡿࡢࢆዡບࡍࡿ࡜࠸࠺ே஦ࢆᥦ᱌ࡋࡓሙྜ࡟ࠊ㐠Ⴀ఍㆟ࡢⓙࡉࢇࡀࡑࢀ࡟㈶ྠࡃࡔ
ࡉࡿ࠿࡝࠺࠿࡜࠸࠺ࡇ࡜ࡶ୍ࡘ⪃࠼࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࠋ
㸦㛗㇂㸧 ࡔ࠿ࡽࠊࡑࡇ࡛࡝࠺࠸࠺ྡ๓ࢆ௜ࡅࡿ࠿࡛ࡍࡅࢀ࡝ࡶࠊࣉࣟࢪ࢙ࢡࢺ෸ᩍᤵࠊ࠶
ࡿ࠸ࡣࡶࡗ࡜ศ࠿ࡾࡸࡍࡃゝࡗࡓࡽࠊ㸰ᖺ෸ᩍᤵ࡜࠿ࠊ㸱ᖺ෸ᩍᤵ࡜࠸࠺ࡼ࠺࡞ࠊ࠸ࢃࡺࡿ
㏻ᖖࡢ෸ᩍᤵ࡜ࡣ㐪࠺ே஦࡛࠶ࡾࠊὶືᛶࢆ㧗ࡵࡿ୍ࡘࡢ᪉⟇ࡔ࡜࠸࠺ࡇ࡜࡛࠶ࢀࡤࠊࡈ⌮ゎ࠸ࡓࡔࡅࡿྍ⬟ᛶࡣ㧗࠸ࡢ࡛ࡣ࡞࠸࠿࡜ᛮ࠸ࡲࡍࡀࠋ㸦すᮧ㸧 ᇶ⏕◊ࡶ๓࡟ࡑࡢࡼ࠺࡞ᙧ࡛ຓᩍࡢேࢆࡑࡢ㒊ᒇࡢ෸ᩍᤵ࡟ୖࡆ࡚ࠊእ㒊࡟ฟ࡚ᩍᤵ࡟࡞ࡽࢀࡓ࡜࠸࠺᪉ࡢ౛ࡀ࠶ࡾࡲࡍࡢ࡛ࠊඛ࡯࡝ࡢ඲ࡃୖࡀࢀ࡞࠸ࠊࡑ࠺࠸࠺ࡶࡢࡀ౑
࠼࡞࠸࡜࠸࠺≧ἣ࡛ࡣ࡞࠸࡜ᛮࡗ࡚࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ࡛ࡶࠊࡑࡢሙྜࡣఱ࡜࡞ࡃ᪼௵ࡉࡏࢀࡤືࡅࡿ࡜࠸࠺᮲௳ࡀ࠶ࡗࡓ
࠿ࡽ࡜࠸࠺ࡇ࡜࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡑࡢ࡜ࡁࡣ᮲௳ࡀ࠶ࡗࡓ࡜࠸࠺ࡼࡾࡶࠊࡑࢀࢆࡋ࡞࠸࡜ᩍᤵ࡟ࡣ࡞࠿࡞࠿ຓᩍ࠿
ࡽ⾜ࡅ࡞࠸࡜࠸࠺ࡇ࡜ࡶ࠶ࡗ࡚ࡢุ᩿࡛ࡍࡡࠋࡑࡢ࡜ࡁࡣ㠀ᖖ࡟࠺ࡲࡃࡑࡢᚋ࡟ᩍᤵ࡟᪼௵
ࡉࢀࡓ࡜࠸࠺౛ࡀ࠶ࡾࡲࡍࠋ ᫬㛫ࡢ᪉ࡀᑡࡋ㏕ࡗ࡚ࡲ࠸ࡾࡲࡋࡓࡢ࡛ࠊ◊✲࡟㛵ࡋ࡚ࡢ࡜ࡇࢁࡣࡇࡇࡲ࡛࡟ࡉࡏ࡚࠸ࡓ
ࡔࡁࡲࡍࡀࠊࡼࢁࡋ࠸࡛ࡍ࠿ࠋ ࡑࢀ࡛ࡣࠊ⥆࠸࡚ࠊ㸰␒┠ࡢඹྠ฼⏝࡜ඹྠ◊✲࡟㛵ࡍࡿά⏝࡟ࡘ࠸࡚࡜࠸࠺ࡇ࡜࡛ࠊࡇ
ࢀࡶ㔝⏣ඛ⏕ࡢ᪉࠿ࡽࠋϩ ඹྠ฼⏝࣭ඹྠ◊✲ࡢ᥎㐍㸦㔝⏣㸧 ࡑࢀ࡛ࡣࠊ⡆༢࡟ࡈㄝ᫂࠸ࡓࡋࡲࡍࠋ
 ㈨ᩱ㸱㸦3㸧ࢆࡈぴࡃࡔࡉ࠸ࠋᖹᡂ  ᖺ࠿ࡽ  ᖺ࡟࠿ࡅ࡚ࠊᚑ᮶ࡢඹྠ฼⏝◊✲㸦⾲ࡢ㔜Ⅼඹྠ฼⏝◊✲࠿ࡽ኱ᆺࢫ࣌ࢡࢺࣟࢢࣛࣇඹྠ฼⏝ᐇ㦂ࡲ࡛㸧࡟ຍ࠼ࡲࡋ࡚ࠊDSLM ඹྠ฼⏝ᐇ㦂ࠊḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮ඹྠ฼⏝ᐇ㦂ࠊࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫᐇ᪋࡜࠸࠺ࡼ࠺
࡞᪂ࡋ࠸㡯┠ࢆタࡅࡲࡋࡓࠋ࠿ࡘࡑࡢ࡜ࡁ࡟ࠊ3 ࡟࠶ࡿࡼ࠺࡞⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮࡜
࠸࠺ࡶࡢ࡟≉௵෸ᩍᤵ࡜ࡋ࡚㔜ಙࡉࢇ࡜ட஭ࡉࢇࢆ㓄⨨ࡋࡲࡋ࡚ࠊ⏕≀ᶵ⬟᝟ሗศᯒᐊ࡜ࠊ
ගᏛゎᯒᐊ࡜࠸࠺ࡶࡢࢆタࡅࡲࡋࡓࠋࡑࡢຠᯝࡀ࠶ࡾࠊ ᖺᗘ࠿ࡽ  ᖺᗘ࡟࠿ࡅ࡚ඹྠ฼
⏝◊✲ࡢᛂເᩘࡀ୍Ẽ࡟ቑຍࡋ࡚ࠊࡑࡢᚋࠊ ௳࠶ࡓࡾࡲ࡛ቑ࠼࡚ࡁࡓ࡜࠸࠺ࡢࡀ⌧≧࡛ࡍࠋึࡵ࡚ඹྠ฼⏝◊✲࡟ᛂເࡍࡿ࡜ࡁ࡟ᩜᒃࡀ㧗࠸࡜࠸࠺ࡼ࠺࡞ࡈពぢࡶࡈࡊ࠸ࡲࡋ࡚ࠊ
ࡇࡢ㸰ேࢆ❆ཱྀ࡟ࠊ࡝ࡢ㒊㛛࣭◊✲ᐊ࡜ඹྠ฼⏝◊✲ࡋࡓࡽ࠸࠸࠿࡜࠸࠺ࡼ࠺࡞┦ㄯ࡟஌ࡿ− 64 −

࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡶጞࡲࡗ࡚࠾ࡾࠊ ௳๓ᚋࡲ࡛ቑ࠼࡚ࡲ࠸ࡾࡲࡋࡓࠋ ⣧⢋࡟ඹྠ◊✲ࢆࡍࡿࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊࡇࡢ஧ࡘࡢࢭࣥࢱ࣮ࡢᐊࡣࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕
ࢡࢫ࡟㛵ࡍࡿࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࢆᐇ᪋ࡍࡿࠊ࠶ࡿ࠸ࡣ࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫ࡟㛵ࡍࡿࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࢆᐇ᪋ࡍࡿ࡜࠸࠺ࡇ࡜ࢆ㏻ࡌ࡚ࠊ඲ᅜࡢ◊✲⪅࡟ᑐࡍࡿ᪉ἲㄽࡢࢧ࣮ࣅࢫ
ࢆ⾜࠺࡜࠸࠺ࡇ࡜ࡶ⾜ࡗ࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊࣂ࢖࢜ࣜࢯ࣮ࢫࡣ࣓ࢲ࢝࡜࢔ࢧ࢞࢜ࡀᒎ㛤ࡉࢀ࡚࠾ࡾࡲࡋ࡚㸦3㸧ࠊࡑࢀ௨እ࡟≉ู࡞஦ᴗ㈝࡟ᇶ࡙ࡃ IBBP ࢭࣥࢱ࣮࡟ࡼࡿ⏕≀㑇ఏ㈨※᪂つಖᏑᢏ⾡㛤Ⓨࡢඹྠ฼⏝◊✲ࢆᖹᡂ  ᖺᗘ࠿ࡽ㛤ጞࡍࡿ㸦3㸧࡜࡜ࡶ࡟ࠊ⌮◊࡜ࡢࢱ࢖࢔ࢵࣉ࡛ࡸࡗ࡚࠸ࡿ᳜
≀⛉Ꮫ᭱ඛ➃◊✲ࢿࢵࢺ࣮࣡ࢡ㸦3㸧ࡶࠊࡑࡢάືࡢ୰࡛ඹྠ฼⏝ᐇ㦂ࢆ⾜ࡗ࡚࠸ࡿ࡜࠸
࠺ࡇ࡜࡛ࡍࠋࡇࡢࡼ࠺࡟ࠊᚑ᮶ࡢ㐠Ⴀ㈝஺௜㔠࡟ࡼࡿඹྠ฼⏝ᐇ㦂ࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ᪂ࡋ࠸
஦ᴗ㈝࡟ࡼࡿඹྠ฼⏝ᐇ㦂ࡶቑࡸࡋ࡚࠸ࡿ࡜࠸࠺ࡢࡀ⌧≧࡛ࡍࠋ኱య௨ୖ࡛ࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋࡑࢀ࡛ࡣࠊඹྠ฼⏝࣭ඹྠ◊✲ࡢά⏝࡟㛵ࡋ࡚ࡈពぢࠊࡈ㉁ၥ➼ࡀࡈࡊ࠸ࡲࡋࡓࡽ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ IBBP ࡀ୍␒᪂ࡋࡃⓎ㊊ࡋ࡚࠸ࡿࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊࡇࢀ࡟ࡘ࠸࡚ࡢࡈពぢࡀ࢔ࣥࢣ࣮ࢺᅇ
⟅ࡢ୰࡟ᗄࡘ࠿࠶ࡾࡲࡍࠋ㈨ᩱ㸳ࡢ㸲࣮࣌ࢪ┠ࡢពぢ㸱ࡢ࡜ࡇࢁ࡟ࠊ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ
࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࡀ㧗ࡃホ౯࡛ࡁࡿ࡜࠸࠺ࡇ࡜ࡀ♧ࡉࢀ࡚࠸ࡲࡍࠋࡑࢀ࠿ࡽࠊᮏࣉࣟࢪ࢙
ࢡࢺࡣ௒ᚋ᪂つࣔࢹࣝ⏕≀ࡢ㛤Ⓨ◊✲࡜࡜ࡶ࡟ᣑ඘ࡍ࡭ࡁ㔜せㄢ㢟࡛࠶ࡿ࡜࠸࠺ᣦ᦬࡛ࡍࠋពぢ㸲࡛ࡣࠊIBBP ࢭࣥࢱ࣮ࡣඹ㏻㑇ఏᏊ㈨※ࡢࣂࢵࢡ࢔ࢵࣉࢆࢧ࣏࣮ࢺࡍࡿయไ࡛࠶ࡿࡀࠊ
ࡏࡗ࠿ࡃࡢయไ࡞ࡢ࡛ࠊࡶ࠺ᑡࡋ࢔ࣆ࣮ࣝࡀ࠶ࡗ࡚ࡶࡼ࠸ࡼ࠺࡟ᛮࢃࢀࡿࠊࡲࡓࠊ⌮◊ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ࡸ⇃ᮏ኱Ꮫࡢ CARD ࡜ࡢᕪู໬࡟ຍ࠼ࠊ༠ຊయไࡶⓎᒎࡍࡿ࡜ࡼ࠸ࡼ
࠺࡟ᛮࢃࢀࡿ࡜࠸࠺ࡈពぢࢆ㡬࠸࡚࠸ࡿࡢ࡛ࡍࡀࠊࡇࢀ࡟㛵ࡋ࡚ᑠᯘඛ⏕ࠊࡈㄝ᫂ࢆ࠾㢪࠸ࡋࡲࡍࠋ㸦ᑠᯘ㸧 ௒ࡢ࣏࢖ࣥࢺ࡟㛵ࡋ࡚⡆༢࡟ࡈㄝ᫂ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍࠋ᫖ᖺᗘࡲ࡛ IBBP ࢭࣥࢱ࣮ࡢࢭࣥࢱ࣮㛗ࢆࡋ࡚࠾ࡾࡲࡋࡓࡢ࡛ࠊࡑࡢ㛵ಀ࡛࠾ヰࡋࡉࡏ࡚࠸ࡓࡔࡃࡢ࡛ࡍࡀࠊIBBP
࡟ࡘ࠸୍࡚␒㔜せ࡞࣏࢖ࣥࢺࡣࠊ㡸࠿ࡿࢧࣥࣉࣝࡣ◊✲㏵ୖࡢࡶࡢ࡛ࡍࠋࡔ࠿ࡽࠊࡍࡗ࠿ࡾ
◊✲ࡀ⤊ࢃࡗ࡚ࠊ௚ே࡟ᥦ౪࡛ࡁࡿࡼ࠺࡞ࡶࡢ࡛ࡣ࡞ࡃ࡚ࠊኻࢃࢀࡓࡽ୍࠿ࡽࡲࡓࡑࡢᐇ㦂ࢆጞࡵ࡞ࡅࢀࡤ࠸ࡅ࡞ࡃ࡞ࡿࠊࡑ࠺࠸࠺㔜せ࡞ࢧࣥࣉࣝࢆ㡸࠿ࢁ࠺࡛ࡣ࡞࠸࠿ࠊࡑࢀ࡟ࡼࡗ
࡚᪥ᮏࡢᇶ♏◊✲ࡢ♏ࡢ୍➃ࢆ⠏ࡃ࡜࠸࠺ࡢࡀ኱ࡁ࡞┠ⓗ࡛ࡍࠋᚑ࠸ࡲࡋ࡚ࠊࢹ࢕ࢫࢺࣜࣅ
࣮ࣗࢺࡍࡿࡇ࡜࡟ࡼࡗ࡚ࢥ࣑ࣗࢽࢸ࢕࣮࡟㈉⊩ࡍࡿ࡜࠸࠺ࡢ࡛ࡣ࡞ࡃ࡚ࠊಶࠎࡢ◊✲⪅ࡀᣢࡗ࡚࠸ࡿᐇ㦂㏵ୖࡢࢧࣥࣉࣝࢆ㡸࠿ࡿࠋࡑࡢព࿡࡟࠾࠸࡚ࠊ࢔ࣥࢣ࣮ࢺࡢ㸲࣮࣌ࢪࡢពぢ㸲࡟࠶ࡿࡼ࠺࡞⌮◊ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ࡸ⇃ᮏ኱Ꮫࡢ CARD ࡣࠊฟ᮶ୖࡀࡗࡓ◊✲ࡶࡋࡃࡣࣃࣈࣜࢵࢩࣗࡋࡓ࠸ࢁ࠸ࢁ࡞࣐ࢸࣜ࢔࡛ࣝࠊࡑࢀࢆ㡸࠿ࡗ࡚ಖ⟶ࡋࡘࡘࢹ࢕ࢫࢺࣜࣅࣗ
࣮ࢺࡍࡿ࡜࠸࠺ࡶࡢ࡛ࡍࡢ࡛ࠊࡑࡇࡀ୍⥺ࢆ⏬ࡍࡇ࡜ࡀ࡛ࡁࡿ࡜ࡇࢁ࡛ࡍࠋ

− 65 − ࡶ࠺୍ࡘࠊࢃࢀࢃࢀࡢ IBBP ࢭࣥࢱ࣮ࡣࠊ࣓࢖ࣥࢆ㠀ࣔࢹࣝ⏕≀ࠊࡑ࠺࠸࠺ゝ࠸᪉ࡣࡕࡻ
ࡗ࡜㐪࠺ࡢ࡛ࡍࡀࠊࢼࢩࣙࢼࣝࣂ࢖࢜ࣜࢯ࣮ࢫ࡛ᢅ࠺ࡼ࠺࡞ࣔࢹࣝ⏕≀ࡣࢼࢩࣙࢼࣝࣂ࢖࢜
ࣜࢯ࣮ࢫ࡛࣓࢖ࣥ࡟ࡸࡗ࡚࠸ࡓࡔࡁࠊࢃࢀࢃࢀࡣࡑࢀ௨እࡢ⏕≀࡛ࡍࠋࡑࢀ࡛ࠊ௒ゝ࠸ࡲࡋࡓࡼ࠺࡟◊✲㏵ୖࡢࡶࡢࢆ㡸࠿ࢁ࠺࡜࠸࠺࡜ࡇࢁ࡛ࠊࡲࡓ୍ࡘ⥺ᘬࡁࡀࡉࢀ࡚࠾ࡾࡲࡍࠋ ࡜࠸࠺ࡇ࡜࡛ࠊࡶࡕࢁࢇ⇃ᮏ኱Ꮫࡢඛ⏕ࡶ IBBP ࡢ᥎㐍ጤဨ఍ࡢጤဨ࡜ࡋ࡚ධࡗ࡚࠸ࡓࡔ
ࡁࡲࡋ࡚ࠊࡑࡕࡽࡢ᪉࠿ࡽࡢពぢࠊࡶࡋࡃࡣ༠ຊయไࡀྲྀࢀࡿࡢࡔࡗࡓࡽࠊࡑࡢࡼ࠺࡞యไ
ࢆྲྀࡿࡼ࠺࡟⪃࠼࡚࠾ࡾࡲࡍࡀࠊ⌧ᅾࡢ࡜ࡇࢁࡣ௒ゝ࠸ࡲࡋࡓࡼ࠺࡞⥺ᘬࡁࢆࡋ࡚ࠊࡑࢀࡒ
ࢀࡢᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ ࡶ࠺㸯Ⅼࡣࠊ㛤Ⓨ◊✲࡜࠸࠺ᩥゝࡀฟ࡚ࡁࡲࡋࡓࡅࢀ࡝ࡶࠊIBBP ࢭࣥࢱ࣮ࡣࡓࡔ༢࡞ࡿ෭
ⶶᗜ࡜࠸࠸ࡲࡍ࠿ࠊ㡸࠿ࡿࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ௒ࡲ࡛෾⤖ಖᏑ࡞࡝ࡀ࡛ࡁ࡞࠿ࡗࡓࡶࡢࡣࢃࢀ
ࢃࢀ࡛ࡶ㡸࠿ࡾࡼ࠺ࡀ࡞࠸࡛ࡍࡋࠊ౛࠼ࡤ㟁※ࡀṆࡲࡿ࡜࠿ỈࡀṆࡲࡿ࡜ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚
࡞࡝ࡣ⤯࠼࡚ࡋࡲ࠺ࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺ࡶࡢࢆ࡝࠺ࡍࡿࡢ࠿ࠋࡑࢀ࡟ࡣ᪂ࡋ࠸ಖᏑ
᪉ἲࢆ㛤Ⓨࡋࡼ࠺࡜࠸࠺ࡇ࡜࡛ࠊ㛤Ⓨ◊✲ࣉࣟࢪ࢙ࢡࢺࢆཤᖺࡣ㸷௳ࠊ௒ᖺᗘࡣከศ  ௳ࡔࡗࡓ࡜ᛮ࠸ࡲࡍࡀࠊ᥇ᢥࡋ࡚࠾ࡾࡲࡍࠋ᫖ᖺᗘࡢᡂᯝ࡛ࡍࡀࠊࡇࢀࡣඹྠ◊✲࡛ࡍࡀࠊி㒔኱Ꮫ࡜ࡢ㛤Ⓨ◊✲ࡢࣉࣟࢪ࢙ࢡࢺ࡛ࢮࢽࢦࢣࡢ෾⤖ಖᏑࡶྍ⬟࡟࡞ࡾࠊࡑࢀࢆᐇ㝿࡟ಖᏑࡢ᪉࡟⏕࠿ࡋ࡚࠸ࡁࡓ࠸࡜࠸࠺ὶࢀ࡛㐍ࢇ࡛࠾ࡾࡲࡍࠋ⡆༢࡟ゝ࠺࡜ࠊࡑࡢ㸰Ⅼ࡛ࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋ௚࡟ࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࡣࠊࡶ࠺ᑡ
ࡋ࢔ࣆ࣮ࣝࡀ࠶ࡗ࡚ࡶࡼ࠸࡜࠸࠺ࡢࡣࡁࡗ࡜ᗈሗࡔ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ౛࠼ࡤ௒ࡢࡼ࠺࡞෾⤖ಖᏑࡢඹྠ◊✲ࡀጞࡲࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡣⓙࡉࢇࡣࡈᏑࡌ࡛ࡋࡻ࠺࠿ࠋࡸࡣࡾࡑ࠺࠸࠺࡜
ࡇࢁ࡛ࡍࡢ࡛ࠊࡶ࠺ᑡࡋ࠸࠸᪉ἲࢆ⪃࠼࡚࠸ࡃ࡜࠸࠺ࡇ࡜ࡀࡈᣦ᦬ࡢࡼ࠺࡟ᚲせ࡟࡞ࡗ࡚ࡁ
࡚࠸ࡿ࠿࡜ᛮ࠸ࡲࡍࠋ
㸦ᑠᯘ㸧 ࡑ࠺࡛ࡍࡡࠋIBBP ࢭࣥࢱ࣮ࡢ᪉࡛ࡶᗈሗࢆ࡝࠺ࡍࡿࡢ࠿ࠋᐇ㝿࡟ࡣࡇࢀࡣ඲ᅜࡢ
㸵኱ᏛࡀࢧࣈᣐⅬ࡜ࡋ࡚ᗈሗࡶᢸᙜࡋ࡚࡜࠸࠺ࡇ࡜࡟࡞ࡗ࡚࠾ࡾࡲࡍࡀࠊࡑࢀࡒࢀࡢᣐⅬࡈ࡜࡟ࡤࡽࡤࡽ࡞ᗈሗࡢࡸࡾ᪉࡛ࡍࠋ㠀ᖖ࡟࠸ࢁ࠸ࢁ࡞࡜ࡇࢁࢆᅇࡗ࡚࠸ࡓࡔࡅࡿ࡜ࡇࢁࡶ࠶
ࡿࡋࠊࡑ࠺࡛ࡣ࡞࠸ሙྜࡶ࠶ࡾࡲࡍࡢ࡛ࠊ௒ᅇࡣᐇົ⪅ࡢᢸᙜ⪅఍㆟ࢆ㛤ࡁࡲࡋ࡚ࠊࡑࡢ㎶ࢆᚭᗏࡋ࡚ࠊ࡝ࡢࡼ࠺࡟ᾐ㏱ࡉࡏ࡚࠸ࡃ࠿ࠋ↓⌮࡟㡸࠿ࡗ࡚ᩘࢆቑࡸࡍ࡜࠸࠺ព࿡࡛ࡣ࡞ࡃ
࡚ࠊᮏᙜ࡟฼⏝ࡋࡓ࠸࡜࠸࠺ேࢆ᥀ࡾ㉳ࡇࡍ࡜࠸࠺ࡇ࡜ࢆࡋ࡚࠸ࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ௚࡟ඹྠ฼⏝࡟㛵ࡋ࡚࡝࠺࡛ࡋࡻ࠺࠿ࠋఱ࠿ࡈ㉁ၥࡣࠋ
㸦Ⲩᮌ㸧 ኱Ꮫඹྠ฼⏝ᶵ㛵࡜࠸࠺ࡇ࡜࡛ከศᅜෆࡢ฼⏝ࢆ⪃࠼࡚࠸ࡽࡗࡋࡷࡿ࡜ᛮ࠸ࡲࡍ
ࡀࠊࡇࡢඹྠ฼⏝ࡢ୰࡟ᅜ㝿ⓗ࡞ࡶࡢࢆධࢀࡿ࡜࠸࠺ࡇ࡜ࡣ࠸࠿ࡀ࡛ࡍ࠿ࠋࢃࢀࢃࢀࡢ࡜ࡇ
ࢁࡣࡑࢀࢆࡔ࠸ࡪࡸࡾฟࡑ࠺࡜ࡋ࡚ࠊᐇ㝿࡟ࡸࡾฟࡋ࡚࠸ࡿࡢ࡛ࡍࡀࠋ

− 66 −㸦すᮧ㸧 ḟࡢ㡯┠ࡢᅜ㝿㐃ᦠࡢ࡜ࡇࢁ࡛ࠊࡑࢀ࡟㢮ࡋࡓ࣎ࢺ࣒࢔ࢵࣉᆺࡢᅜ㝿㐃ᦠࡀฟ࡚ࡲ࠸ࡾࡲࡍࡢ࡛ࠊࡑࢀࡀ୍ࡘ㛵ࢃࡿ࡜ᛮ࠸ࡲࡍࠋ
㸦Ⲩᮌ㸧 බເᆺࡢᅜ㝿ඹྠ฼⏝࡜࠸࠺ࡼ࠺࡞ࡶࡢࡣ࠶ࡾࡲࡍ࠿ࠋ㸦すᮧ㸧 බເᆺ࡜࠸࠺ࡢ࡛ࡣ࡞࠸࡛ࡍࡡࠋ
㸦㔝⏣㸧 ⌧≧ࢆ࠾ヰࡋࡋࡲࡍ࡜ࠊࡇ࠺࠸࠺◊✲఍ࡸ኱ᆺࢫ࣌ࢡࢺࣟࢢࣛࣇඹྠ฼⏝ᐇ㦂࡞࡝࡟እᅜࡢ᪉ࡀཧຍࡋࡓ࠸࡜࠸࠺஦౛ࡣ᪤࡟ఱ௳࠿ฟ࡚࠾ࡾࡲࡍࠋᅜෆ࡟ධࡗ࡚࠿ࡽࡢ᪑㈝࡜⁫ᅾ㈝ࡣࢧ࣏࣮ࢺࡋ࡚࠾ࡾࡲࡍࠋ
㸦Ⲩᮌ㸧 ᪥ᮏ࡟᮶ࡽࢀࡿ᪑㈝ࡢࢧ࣏࣮ࢺࡣࠋ
㸦㔝⏣㸧 ࡇࢀࡣไᗘୖ࡛ࡁ࡞࠸ࡢ࡛ࠊ௒ࡢ࡜ࡇࢁࢧ࣏࣮ࢺࡣࡋ࡚࠾ࡾࡲࡏࢇࠋ
㸦Ⲩᮌ㸧 ไᗘୖ࡛ࡁ࡞࠸ࠋ
㸦㔝⏣㸧 ࠼࠼ࠊ࠸ࢃࡺࡿࡇࡢ㐠Ⴀ㈝஺௜㔠ࡢไ㝈࡛ࡍࠋ㸦Ⲩᮌ㸧 ࢃࢀࢃࢀࡣ㐠Ⴀ㈝஺௜㔠࠿ࡽฟࡋ࡚࠸ࡲࡍࡀࠋ
㸦㔝⏣㸧 ไᗘࢆኚ࠼ࢀࡤᜍࡽࡃ࡛ࡁࡿࡢࡔࢁ࠺࡜ᛮ࠸ࡲࡍࡀࠊࢃࢀࢃࢀࡢ࡜ࡇࢁࡣ௒ࡢ࡜
ࡇࢁ⾜ࢃ࡞࠸࡜࠸࠺ᚑ᮶㏻ࡾࡢᙧ࡛ࡸࡗ࡚࠾ࡾࡲࡍࠋ࠶࡜ࡣ஦ົࢧ࢖ࢻࡢ⪃࠼ࡿண⟬ไᗘ࡜ࡢ㛵ࢃࡾ࡟࡞ࡗ࡚ࡃࡿ࡜ᛮ࠸ࡲࡍࠋ ௚ࡢ㐃ᦠ⤒㈝࡟ᇶ࡙ࡃࢩ࣏ࣥࢪ࣒࢘࡞࡝ࠊࡑ࠺࠸࠺ࡶࡢࡣ༑ศ᪑㈝ࡶ࢝ࣂ࣮ࡋ࡚࠾ࡾࡲࡍ
ࡀࠊᚑ᮶ࡢඹྠ฼⏝◊✲ண⟬࡛ࡣࠊᅜෆ࡟ධࡗ࡚࠿ࡽࡢ᪑㈝ࠊ⁫ᅾ㈝࡜࠸࠺ࡇ࡜࡛ࡸࡗ࡚࠾ࡾࡲࡍࠋ㸦Ⲩᮌ㸧 ࠿ࡘ࡚㝶ศ㆟ㄽࡀ࠶ࡾࡲࡋ࡚ࠊ኱Ꮫඹྠ฼⏝ᶵ㛵ࡣᅜෆࡢ኱Ꮫࡢඹྠ฼⏝ᶵ㛵࡛࠶ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡀࠊࡑࢀ࡛ࡣࡸࡣࡾ⊃࠸ࡋࠊࡶࡗ࡜࢖ࣥࢱ࣮ࢼࢩࣙࢼࣝ࡟࡞ࡗࡓ᪉ࡀ࠸
࠸ࡢ࡛ࡣ࡞࠸࠿࡜࠸࠺ࡇ࡜࡛ࢃࢀࢃࢀࡣࡸࡗ࡚࠸ࡿࡢ࡛ࡍࡀࠊ࠾㔠ࡢၥ㢟ࡀ࠶ࡲࡾၥ㢟࡞ࡃࡍࡗ࡜౑࠼ࡿࡼ࠺࡟࡞ࡗ࡚ࡸࢀ࡚࠸ࡿࡢ࡛ࡍࡡࠋࡓࡔࠊ⤒῭ⓗ࡟ࡁࡘ࠸ࡢࡣ☜࠿࡛ࡍࠋ
㸦㔝⏣㸧 ⚾ࡢグ᠈࡛ࡣࠊ஦ົࢧ࢖ࢻࡀ㐣ཤ࡟࠾࠸࡚ࡣ᢬ᢠࡋࡓ࡜ᛮ࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 㛗㇂ඛ⏕ࡢ⺮ⓑ◊࡛ࡶࡸࡗ࡚࠾ࡽࢀࡲࡍࡡࠋ
㸦㛗㇂㸧 ⺮ⓑ◊ࡣ⮬⏤࡟ࡸࡗ࡚࠸ࡲࡍࠋእᅜ࠿ࡽ኱Ꮫ㝔⏕ࢆᣍࡃࡢࡶࠊࡇࡢᯟ⤌ࡳࡢඹྠ฼⏝ᐇ᪋ศ࡛࡛ࡁࡲࡍࠋࡇࢀࡶ኱ኚ᢬ᢠࡀ࠶ࡗࡓࢃࡅ࡛ࡍࡀࠊࡸࡗ࡚࠸ࡿ࡜ࡇࢁࡢ๓౛ࢆぢࡏࡿ࡜ᬑ㏻࡟኱୔ኵࡔ࡜ᛮ࠸ࡲࡍࠋ

− 67 −

㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍ࠿ࠋ
㸦㛗㇂㸧 ୍ࡘࡼࢁࡋ࠸࡛ࡍ࠿ࠋ࢞ࣂࢼࣥࢫࡢほⅬ࡛ࡍࠋ㔜Ⅼඹྠ◊✲ࠊඹྠ฼⏝◊✲ࡢࡼ
࠺࡞ࠊ㈨㔠ⓗ࡟ࡶ኱ࡁ࡞ඹྠ◊✲࡛ࡍࡅࢀ࡝ࡶࠊࡑࡇ࡛⏕ࡌࡿ࡛࠶ࢁ࠺▱㈈ࢆ⤌⧊࡜ࡋ࡚ࡁ
ࡕࢇ࡜࣮࢜࢞ࢼ࢖ࢬࡍࡿࡓࡵ࡟ఱ࠿ᕤኵࡉࢀ࡚࠸ࡿࡢ࡛ࡋࡻ࠺࠿ࠋ
㸦㔝⏣㸧 ࡶࡕࢁࢇᑂᰝࡢ㐣⛬࡛ࠊ㛤Ⓨࡍࡿࣔࢹࣝࡸᢏ⾡࡟࡝ࢀࡄࡽ࠸ᬑ㐢ᛶࡀ࠶ࡿ࠿ࠊࡑ
ࢀ࠿ࡽࠊࡑࢀࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠊ࠶ࡿ࠸ࡣ㛤Ⓨࡉࢀࡓ࡜ࡁ࡟࡝ࢀࡔࡅ඲ᅜⓗࢽ࣮ࢬࡀ࠶ࡿ࠿
࡜࠸࠺ほⅬ࡛ࡢᑂᰝࢆࡋ࡚࠾ࡾࡲࡍࠋࡓࡔࠊ஦ᚋࡢホ౯ࡲ࡛ࢃࢀࢃࢀࡀࣇ࢛࣮ࣟࡋ࡚⾜ࡗ࡚࠸ࡿ࠿࡜࠸࠺࡜ࠊࡲࡔࡑࡇࡲ࡛ࡣࣇ࢛࣮ࣟࡋ࡚࠾ࡾࡲࡏࢇࠋ ࡑࢀ࠿ࡽࠊ㔜Ⅼඹྠ฼⏝◊✲࡟㛵ࡋ࡚ࡣ㸱ᖺࡀࡵ࡝࡛ࠊ㸱ᖺࡓࡗࡓࡽᡂᯝ࡟ࡘ࠸࡚ࠊ࠸ࢃ
ࡺࡿ࣮࢜ࣉࣥ࡞ᙧࡢࢩ࣏ࣥࢪ࣒࢘ࢆ㛤࠸࡚࠸ࡓࡔ࠸࡚ࠊᡂᯝࡀ࡝ࢀࡔࡅୖࡀࡗࡓ࠿࡜࠸࠺ࡇ
࡜ࢆබ࡟ࡋ࡚࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜ࢆ⩏ົ࡜ࡋ࡚ࡸࡗ࡚࠸ࡓࡔ࠸࡚࠾ࡾࡲࡍࠋ
㸦㛗㇂㸧 ࢃࢀࢃࢀࡶࡑࡢࡼ࠺࡟⪃࠼࡚࠸ࡓࢃࡅ࡛ࡍࡀࠊ኱Ꮫ࡟⏘Ꮫ㐃ᦠᮏ㒊ࡀ࡛ࡁ࡚ࠊ▱㈈㒊ࡸ URA ࡢ❧ሙ࠿ࡽࡳࡿ࡜Ⓨ⏕ࡍࡿ≉チᶒ࡜࠸࠺ࡶࡢࢆ࡝࠺ᢅ࠺࠿ࡶ㔜せどࡉࢀࡲࡍࠋᚲせ࡟࡞ࢀࡤ࠾஫࠸࡟༠㆟ࡍࡿࡢ࡛ࡣ࡞ࡃࠊ◊✲ࢆᐇ᪋ࡍࡿ࡟ᙜࡓࡗ࡚ࡁࡕࢇ࡜ࡋࡓඹྠ◊✲ዎ⣙᭩ࢆྲྀࡾ஺ࢃࡋ࡚ࠊၥ㢟ࡀ㉳ࡇࡽ࡞࠸ࡼ࠺࡞ᙧ࡛ࡸࡗ࡚࠸ࡃ࡜࠸࠺ࡇ࡜ࡀᙉࡃồࡵࡽࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁ࡚࠾ࡾࡲࡍࠋࡔ࠿ࡽࠊ㔜Ⅼඹྠ฼⏝◊✲࡛▱㈈ࡢⓎ⏕ࡍࡿࡼ࠺࡞ᡂᯝࡀ
ồࡵࡽࢀࡿሙྜࠊࡑࢀࢆ࡝࠺ࡍࡿ࠿࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡢ㆟ㄽ࡞ࡋ࡟◊✲⪅ࡢ⤀ኈ༠ᐃ࡛ࡸࡗ
࡚࠸ࡁࡲࡍ࡜࠸࠺ࡢࡣࠊࡸࡣࡾ⤌⧊࡜ࡋ࡚ࡣ୙༑ศ࡛࠶ࡾࠊゝ࠸᪉ࡀᝏ࠸ࡢ࡛ࡍࡀࠊࡼࡁ᫬
௦ࡢ࡞ࡈࡾࡔ࡜ᛮ࠸ࡲࡍࠋ⌮◊ࡣࡑࡇࡣ኱ኚཝࡋ࠸࡛ࡍࡡࠋ
㸦ኴ⏣㸧 ඲㒊ඹྠ◊✲ዎ⣙ࢆ⤖ࢇࡔࡾࡋࡲࡍࡋࠊ◊✲ᡂᯝࡶ㛤♧࡛ࡁ࡞࠸㠀බ㛤ࡢࡶࡢ࡟ࡘ࠸࡚ࡣᶵᐦಖᣢዎ⣙ࢆ⤖ࢇࡔୖ࡛㛤♧ࡍࡿ࡜࠸࠺ࡼ࠺࡞ẁྲྀࡾࡶቑ࠼࡚࠸ࡲࡍࠋࡑࢀ࡞ࡾ
ࡢ▱ⓗ㈈⏘ࡢ㒊⨫ࡀ࠶ࡾࡲࡋ࡚ࠊἲᚊࡢᑓ㛛ᐙࡶ࠸ࡿ࡜࠸࠺≧ἣ࡛ࡸࡗ࡚࠾ࡾࡲࡍࠋ࡛ࡶࠊ
ᇶ♏◊✲ᡤ࡞ࡢ࡛ࠊࡑࡢ㎶ࡣ࡝ࡇࡲ࡛ຊࢆධࢀ࡚ࡸࡿ࠿࡜࠸࠺ࡢࡣ࠶ࡿ࡜ᛮ࠺ࡢ࡛ࡍࡀࠋ
㸦ᒣᮏ㸧 ᙜ↛ࡁࡕࢇ࡜ࡋ࡚࠸࡞࠸࡜࠸ࡅ࡞࠸࡜ࡇࢁ࡛ࡍࡀࠊ࠾ࡗࡋࡷࡿ࡜࠾ࡾ㠀ᖖ࡟ᙅ࠸Ⅼ࡛ࡍࡡࠋࡑࢀ࠿ࡽࠊ▱㈈࡟㛵ࡍࡿ⪃࠼᪉ࡣࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ⮬యࡶࡑࢇ࡞࡟ᙉࡃ࡞࠸࡛ࡍࡡࠋ㸦㛗㇂㸧 ࡔ࠿ࡽࠊࡇࢀࡣぢ࠼࡟ࡃ࠸ᙧ࡛▱㈈ࡀฎ⌮ࡉࢀ࡚࠾ࡽࢀࡿ࠿ࡶࡋࢀ࡞࠸࡛ࡍࡡࠋ
ࡇࢀࡣࣇ࢛࣮ࣟࡋ࡚࠸࡞࠸࡛ࡍࡶࡢࡡࠋ
㸦஭ཱྀ㸧 ⚾ࡣࡇࡇࡢᒸᓮࡢ▱㈈ࡢ᪉ࡢጤဨࢆࡋ࡚࠸ࡲࡍࡀࠊ◊✲ࢆጞࡵࡿ๓ࡢྲྀࡾ⤌ࡳࡣ࠶ࡾࡲࡏࢇࠋⓙࡉࢇࡀᡂᯝ࡜ࡋ࡚ࠕࡇࢀࡣ≉チࢆྲྀࡾࡓ࠸ࠖ࡜ᥦ᱌ࡀ࠶ࡗࡓ࡜ࡁࡢࡳ࡟ືࡁ

− 68 −

ฟࡍࡶࡢ࡛ࡍ࠿ࡽࠊࡑ࠺࠸࠺ࡇ࡜ࡀ᭱ึ࠿ࡽỴࡲࡗ࡚࠸ࢀࡤ࠸࠸࠿ࡶࡋࢀࡲࡏࢇࡡࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ㸦すᮧ㸧 ࡑࡇࡣᚲせ࡟࡞ࡗ࡚ࡃࡿ࡜⚾ࡶᛮ࠸ࡲࡍࠋ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ ඹྠ฼⏝࣭ඹྠ◊✲࡟㛵ࡋ࡚ࡣ࡝࠺࡛ࡋࡻ࠺࠿ࠋ㸦ሷぢ㸧 ୍ࡘࠊࡇࡢඹྠ฼⏝ࡢศ㔝ࡣ࡝ࡢࡼ࠺࡟Ỵࡵ࡚ࡇࡽࢀࡓࡢ࡛ࡍ࠿ࠋ౛࠼ࡤ᭱ึࡢ
⏕≀ᶵ⬟᝟ሗศᯒᐊࡢḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮࡜࠸࠺ࠊࡇ࠺࠸࠺ࡶࡢࡣ௒ࡣ࡝ࢇ࡝ࢇᏳࡃ
࡞ࡗ࡚࠸ࡿࡋࠊ࠸ࢁ࠸ࢁ࡞኱Ꮫ࡛ࡶ࣐࢖ࢭࢵࢡࡄࡽ࠸ࡔࡗࡓࡽᣢࡗ࡚࠸ࡿ࡜ࡇࢁࡶ࠶ࡿࡋࠊ
ᮏᙜ࡟ࡇࢀࡀᚲせ࡞ࡢ࠿࡞࡜࠸࠺Ẽࡀࡍࡿࡢ࡛ࡍࠋࡶࡗ࡜ࠊ౛࠼ࡤ኱Ꮫ࡛ࡣ࡞࠿࡞࠿࡛ࡁ࡞
࠸ࡼ࠺࡞࡜ࡇࢁ࡟ඹྠ◊✲᪋タ࡜ࡋ࡚ࡢࡑ࠺࠸࠺㒊㛛ࡀ࠶ࡗࡓ᪉ࡀ࠸࠸࠿࡞࡜࠸࠺Ẽࡶࡍࡿࡢ࡛ࡍࡀࠊ࡝࠺࠸࠺㒊㛛ࢆసࡗ࡚࠸ࡃ࠿ࡳࡓ࠸࡞ࡇ࡜ࡣ࡝࠺࡛ࡋࡻ࠺࠿ࠋ
㸦ᑠᯘ㸧 ⚾ࡣ᫖ᖺᗘࡲ࡛⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ࡢࢭࣥࢱ࣮㛗࡛࠶ࡾࡲࡋࡓࡢ࡛ࠊ࠾⟅࠼ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋ☜࠿࡟࠾ࡗࡋࡷࡿ࡜࠾ࡾࠊḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࡀᗄࡘࡶᕷ㈍ࡉࢀࠊࡑࢀࡀ
࠸ࢁ࠸ࢁ࡞኱Ꮫ࡟ධࡗ࡚ື࠸࡚࠸ࡲࡍࠋࡓࡔࠊከࡃࡢேࡀࠕࢹ࣮ࢱࡣྲྀࢀࡿࠋࡑࡢࢹ࣮ࢱࢆ
࡝࠺ᩱ⌮ࡋ࡚ㄽᩥࡲ࡛ᣢࡗ࡚࠸ࡃࡢ࠿ࠋࡑࡇࡀ㠀ᖖ࡟㞴ࡋ࠸ࠖ࡜ゝࡗ࡚࠸ࡿࡢࢆࡼࡃ⪺ࡁࡲࡍࠋ ࡇࡢࢭࣥࢱ࣮࡛ఱࢆࡸࡗ࡚࠸ࡿ࠿࡜࠸࠺࡜ࠊㄽᩥࢆ࡝࠺సࡿ࠿ࠋࢹ࣮ࢱࢆ࡝࠺ྲྀࡿ࠿ࠋ㔜ಙࡉࢇࡀ୰ᚰ࡟࡞ࡗ࡚ࠊ࡝࠺࠸࠺ࢹ࣮ࢱࡢྲྀࡾ᪉ࢆࡋ࡚ࠊࢹ࣮ࢱࢆྲྀᚓࡋࡓᚋࠊ࡝࠺࠸࠺⤫ィฎ⌮ࢆࡋ࡚ࠊ࡝࠺࠸࠺ᙧ࡛ᙜึ࡟ᛮࡗ࡚࠸ࡓࡇ࡜ࢆฟࡋ࡚࠸ࡃ࠿ࠋࡔ࠿ࡽࠊࡑ࠺࠸࠺ព࿡
࡛ࡣ඲ࡃࡢඹྠ◊✲࡜ࡋ࡚ࡸࡗ࡚࠸ࡲࡍࠋከࡃࡢ࡜ࡇࢁࡣࠊࢧࣥࣉࣝࢆ㏦ࡿࠊࢹ࣮ࢱࡀ᮶ࡿࠊ
ࡑࢀࡣࢸ࢟ࢫࢺࣇ࢓࢖ࣝ࡟࠶ࡿࢱࣈ࡛༊ษࡗࡓ⭾኱࡞ࢹ࣮ࢱ࡛ࠊࡑࢀࢆ࡝࠺ࡍࡿࡢ࠿࡜࠸࠺
࡜ࡇࢁ࡛ࠊࡣࡓ࡜ᅔࡗ࡚ࡋࡲ࠸ࡲࡍࠋ
 ࡜࠸࠺ࡇ࡜࡛ࠊࡑࡇ࡛ࡣ⤫ィᏛⓗ࡞ฎ⌮ࡀᚲせ࡛ࡍࠋࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࡣఱࢆࡸࡿ࠿࡜
࠸࠺࡜ࠊ⮬ศ࡛ࣉࣟࢢ࣒ࣛࢆ᭩࠸࡚ࠊ࡝࠺⤫ィฎ⌮ࢆࡋ࡚ࠊ࡝࠺᭷ຠ࡞ࢹ࣮ࢱࢆྲྀࡿࡢ࠿ࠋ
ࡑ࠺࠸࠺࡜ࡇࢁ࡟㔜ࡁࢆ⨨࠸࡚࠾ࡾࡲࡍࠋࡔ࠿ࡽࠊᴟ➃࡞ࡇ࡜ࢆゝ࠼ࡤࠊࢃࢀࢃࢀࡢḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࢆ౑ࢃ࡞ࡃ࡚ࡶࠊ㔜ಙࡉࢇ࡜ඹྠ◊✲ࢆࡋ࡚ࠊ᭱ึ࠿ࡽ࡝࠺࠸࠺ࢹ࣮ࢱࢆఱಶ
࡝ࡢࡼ࠺࡟ྲྀࡗ࡚࠸ࡃࡢ࠿ࢆᡴࡕྜࢃࡏ࡚ࠊእὀࡋ࡚ࡶ࠸࠸ࠋࡑࡢࢹ࣮ࢱࢆᇶ࡟ᙼ࡜୍⥴࡟ࡲࡓඹྠ◊✲ࢆጞࡵ࡚ࠊ᭱⤊ⓗ࡞ࢹ࣮ࢱࡢᙧ࠿ࡽࢹ࣮ࢱ࣐࢖ࢽࣥࢢࡀ࡝࠺࠸࠺ᙧ࡛࡛ࡁࡿࡢ
࠿ࠋࡑࢀࢆࡍࡿ࡜࠸࠺ࡢࡀඹྠ◊✲ࡢ㊃᪨࡛ࡍࠋ
 ྡ๓ࡣḟୡ௦ࢩ࣮ࢣࣥࢧ࣮࡟࡞ࡗ࡚࠾ࡾࡲࡍࡅࢀ࡝ࡶࠊᐇ㝿ࡢෆᐜࡣࡑ࠺࠸࠺ࡇ࡜࡛ࠊࡇ
ࢀࡣ࠿࡞ࡾࡢ㟂せࡀ࠶ࡿ࡜࠸࠺࠿ࠊᮏᙜ࡟ࢹ࣮ࢱࡣ࠶ࡿࡢࡔࡅࢀ࡝ࡶࠊ࡝࠺ㄽᩥ࡟ࡋࡓࡽ࠸
࠸ࡢ࠿ࠊ࡝࠺ࡋࡓࡽ࠸࠸ࡢ࠿ศ࠿ࡽ࡞࠸࡜࠸࠺ேࡀከࡃ࡚ࠊࡑ࠺࠸࠺ඛ⏕᪉࡟࡜ࡗ࡚ࡣࡍࡈ
ࡃ࠸࠸ඹྠ฼⏝ࡢࢩࢫࢸ࣒ࡔ࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋ௒ࡢࡼ࠺࡞ࡇ࡜࡛ࡼࢁࡋ࠸࡛ࡍ࠿ࠋ

− 69 −

㸦ኴ⏣㸧 ㅮ⩦఍ࡶࡉࢀ࡚࠸ࡲࡍࡼࡡࠋ
㸦ᑠᯘ㸧 ࡣ࠸ࠋ㸦ኴ⏣㸧 ࠺ࡕࡢᏛ⏕࡞࡝ࡶࡇࡕࡽ࡛ࡔ࠸ࡪຮᙉࡉࡏ࡚࠸ࡓࡔ࠸࡚ࠊ⮬ศ࡛ࣉࣟࢢ࣒ࣛࢆ⤌ࢇ࡛ゎᯒ࡛ࡁࡿࡼ࠺࡟ࡲ࡛࡞ࡗ࡚࠾ࡾࡲࡍࠋࡑ࠺࠸࠺㠃࡛ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫࡢ࡛ࡁ
ࡿᏛ⏕ࡢᩍ⫱ࢆࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡿࡢ࡛ࠊࡍࡈࡃᙺ࡟❧ࡗ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋ
㸦ᑠᯘ㸧 ㅮ⩦఍࡞࡝ࠊࡑࢀࢆࢃࢀࢃࢀࡣࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫ࡜࿧ࢇ࡛ࠊᖺ࡟㸰ᅇ࣮࣋ࢩࢵ
ࢡ࡜࢔ࢻࣂࣥࢫ࡛ࡸࡗ࡚࠸ࡲࡍࠋ࢔ࢻࣂࣥࢫࡢ᪉࡟ࡣ⤫ィฎ⌮࡞࡝ࡀධࡗ࡚࠸࡚ࠊ࣮࣋ࢩࢵ
ࢡࡢ᪉ࡣ࠸ࢁ࠸ࢁ࡞ゝㄒ࡛ࣉࣟࢢ࣒ࣛࢆ᭩ࡃ࡜࠸࠺࡜ࡇࢁࢆ⩦࠺ࡢ࡛ࡍࠋࡓࡔࠊᩍ࠼ࡿ᪉ࡢ
ᩍᖌ㝕ࡢேᩘࡀ࠶ࡾࡲࡋ࡚ࠊᖺ࡟㸯ᅇࡢࢺ࣮ࣞࢽࣥࢢ࡛༑ᩘྡࡋ࠿ཷࡅධࢀࡿࡇ࡜ࡣ࡛ࡁࡲ
ࡏࢇࠋᐇ㝿࡟ࡣಸ⋡ࡀ㸱㹼㸳ಸ࠶ࡗ࡚ࠊࡑࡇࡣࢃࢀࢃࢀࡶᚰⱞࡋ࠸࡜ࡇࢁ࡛ࡍࠋ
 ࠶࡜ࡣࠊḟୡ௦ࢩ࣮ࢣࣥࢧ࣮ࡢඹྠ฼⏝ࡢᩘࡀࠊࡇࢀࡀඹྠ฼⏝ࢆ௒ࡢయไ࡛ཷࡅධࢀࡽ
ࢀࡿ㝈⏺࡜࠸࠺ࡇ࡜࡛㢌ᡴࡕࡢࡼ࠺࡟࡞ࡗ࡚࠾ࡾࡲࡍࡀࠊ୍᪉࡛ࡣㄽᩥࢆฟࡋ࡚ඹྠ฼⏝ࡀ⤊ࢃࡾࠊࡲࡓ᪂ࡋ࠸᪉ࡀධࡗ࡚ࡃࡿ࡜࠸࠺ᙧ࡛ࠊࡇࡢᩘࡀ୍ᐃ࡟࡞ࡗ࡚࠾ࡾࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ
㸦ᒣᮏ㸧 㔝⏣ࡉࢇࠊఱ࠿㏣ຍࡀ࠶ࡾࡲࡍ࠿ࠋ
㸦㔝⏣㸧 ࢭࣥࢱ࣮࡜ࡋ࡚⤌⧊ࢆ෌⦅ᡂࡋࡓࡢ࡛ࡍࡀࠊ㓄⨨࡛ࡁࡿேᩘࡶ㝈ࡽࢀ࡚࠾ࡾࡲࡋ
࡚ࠊඛ࡯࡝⏦ࡋୖࡆࡓࡼ࠺࡟  ௳ࡄࡽ࠸ࡀ㝈⏺࡜࠸࠺ࡇ࡜࡛ࠊ௒ࠊࢫࢸ࣮ࢩࣙࢼ࣮ࣜ࡞ࣇ
࢙࣮ࢬ࡟ධࡗ࡚࠸ࡲࡍࠋඛ⏕ࡀゝࢃࢀࡓࡼ࠺࡟⤌⧊ࢆࡉࡽ࡟Ⓨᒎࡉࡏ࡚࠸ࡃࠊࢽ࣮ࢬࡀ࠶ࡿ
௨ୖࠊⓎᒎࡉࡏࡿ࡜࠸࠺ࡢࡀ୍ࡘࡢ㐨࡛ࡣ࡞࠸࠿࡜ឤࡌ࡚࠾ࡾࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋඹྠ฼⏝࣭ඹྠ◊✲࡟㛵ࡋ࡚ࡣࡼࢁࡋ࠸࡛ࡋࡻ
࠺࠿ࠋ ࡑࢀ࡛ࡣࠊ⥆ࡁࡲࡋ࡚㸱␒┠ࡢᅜ㝿㐃ᦠ࠾ࡼࡧᗈሗ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚࡜࠸࠺ࡇ࡜࡛ࠊ
ࡇࢀࡣྜྷ⏣ࡉࢇࡢ᪉࠿ࡽࡈㄝ᫂ࢆ࠾㢪࠸ࡋࡲࡍࠋϪ ᅜ㝿㐃ᦠ࡜ᗈሗάືࡢᒎ㛤㸦ྜྷ⏣㸧 ࡈㄝ᫂࠸ࡓࡋࡲࡍࠋ㈨ᩱ㸯ࡢϪ㸦3㸧ࡢᅜ㝿㐃ᦠ࡜ᗈሗάືࡢᒎ㛤࡛ࡍࠋࡼࢁ
ࡋࡃ࠾㢪࠸ࡋࡲࡍࠋ ࡲࡎ᫖ᖺᗘࠊᇶ⏕◊࡛ᅜ㝿㐃ᦠάື࡟ࡘ࠸࡚ఱࢆࡸࡗࡓ࠿࡜࠸࠺ࡈሗ࿌࠿ࡽࡉࡏ࡚࠸ࡓࡔ
ࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ➨㸯࡟ NIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡜࠸࠺ࡢࡣࠊᇶ⏕◊ࡀ࡛ࡁ࡚ࡍࡄ࠿ࡽᖺ࡟
㸰ᅇࠊ࠶ࡿ࠸ࡣ㸯ᅇࠊᐃᮇⓗ࡟㛤ദࡋ⥆ࡅ࡚ࡁࡓᅜ㝿ࢥࣥࣇ࢓ࣞࣥࢫ࡛ࠊ௒ᖺ࡛  ᅇࢆᩘ࠼− 70 −

ࡲࡍࠋࡇࢀࡣྛ PI ࡀ୰ᚰ࡜࡞ࡗ࡚࣮࢜࢞ࢼ࢖ࢬࢆࡋ࡚ࠊ᭱㏆࡛ࡍ࡜እᅜ࠿ࡽ  ྡࡄࡽ࠸ࡢ
᪉ࢆ࿧ࡧ࡞ࡀࡽ኱ࡁ࡞ࢥࣥࣇ࢓ࣞࣥࢫࢆ㛤ࡃ࡜࠸࠺ࡶࡢ࡛ࡍࠋ
 ᫖ᖺᗘࡣ⸨᳃ඛ⏕ࡀ࣮࢜࢞ࢼ࢖ࢬࢆࡋ࡚ࠊ➨  ᅇࡢࢥࣥࣇ࢓ࣞࣥࢫࠕCellular Community in
Mammalian Embryogenesisࠖࢆ㛤ദࡋࡲࡋࡓࠋෆᐜࡣࠕ့ங㢮ึᮇⓎ⏕ࠖ࡜࠸࠺୍ࡘࡢࢸ࣮࣐ࠊ
ࡇࢀࡣ⸨᳃ඛ⏕ࡀᐇ㝿࡟ࡸࡽࢀ࡚࠸ࡿࢸ࣮࣐࡞ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡇࢀࢆ୰ᚰ࡟㞟ࡲࡾࡲࡋࡓࠋ
࠿࡞ࡾ⊃࠸ࢸ࣮࣐࡜࠸࠺ࡇ࡜ࡶ࠶ࡗ࡚ࠊࡇࡇࡲ࡛ࣇ࢛࣮࢝ࢫࡋࡓ఍ࡣ࡞࠿࡞࠿ᣢ࡚࡚࠸࡞࠸࡜࠸࠺ホ౯ࢆཷࡅ࡚࠸ࡲࡍࠋ
 ᜍࡽࡃ NIBB ࢥࣥࣇ࢓ࣞࣥࢫࡢ≉ᚩ࡜ࡋ࡚ࡣࠊ኱ࡁ࡞Ꮫ఍࡟⾜ࡗ࡚ࡋࡲ࠺࡜ࡤࡽࡅ࡚ࡋࡲ
࠺ࠊ࠶ࡿ࠸ࡣࢦ࣮ࢻࣥࡸ࣮࢟ࢫࢺࣥࡢࡼ࠺࡟ࡶ࠺ᑡࡋᗈࡃ࡞ࡗ࡚ࡶࡤࡽࡅ࡚ࡋࡲ࠺࡜ࡇࢁࡀࠊ
ᮏᙜ࡟୍ࡘࡢ࣮࣮࢟࣡ࢻ࡛㞟ࡲࢀࡿ࡜࠸࠺ࡇ࡜࡛ࠊ࠿࡞ࡾホ౯ࢆཷࡅ࡚࠸ࡿࡢ࡛ࡣ࡞࠸࠿࡜
ᛮࡗ࡚࠸ࡲࡍࠋ
 ࡶ࠺୍ࡘࠊ᭱㏆ࡢഴྥ࡛ࡶ࠶ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊඛ࡯࡝すᮧඛ⏕ࡢ᪉࠿ࡽᑡࡋ࠶ࡾࡲࡋࡓ
ࡀࠊ᪂Ꮫ⾡㡿ᇦ◊✲࡞࡝ࡢ◊✲㈝࡜㛵㐃ࡍࡿࢥ࣑ࣗࢽࢸ࢕࣮ࡢᙧᡂࠊ
ࠕ࠾㔠ࡢࡘ࡞ࡀࡾࡀࠖࡳ
ࡓ࠸࡟࡞ࡿ࡜᎘࡞ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺ࡶࡢࡀᐇ㝿࡟኱ࡁ࡞࢔ࢡࢸ࢕ࣅࢸ࢕࣮࡜࡞ࡗ࡚
ࡁ࡚࠸࡚ࠊ௒ᅇࡢ NIBB ࢥࣥࣇ࢓ࣞࣥࢫࡣ⸨᳃ඛ⏕ࡀ௦⾲ࡢࠕ့ங㢮ึᮇⓎ⏕ࡢ⣽⬊ࢥ࣑ࣗࢽࢸ࢕࣮ࠖ࡜ࡢඹദ࡜ࡋ࡚⾜࠸ࡲࡋࡓࠋࡑࢀ࡟ࡼࡗ࡚ࡉࡽ࡟ࢥ࣑ࣗࢽࢸ࢕࣮࡟ᑐࡋ࡚ࡢⓎಙࡶ㧗ࡲࡗࡓࡢ࡛ࡣ࡞࠸࠿࡜ᛮࡗ࡚࠸ࡲࡍࠋ ➨㸰࡟ࡸࡗ࡚࠸ࡿࡇ࡜࡜ࡋ࡚ࡣ EMBL㸦ḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸧࡜ࡢᅜ㝿ඹྠ◊✲࡛ࡍࠋୖ㔝ඛ⏕ࡀ୰ᚰ࡟࡞ࡗ࡚ࠊ ᖺࡄࡽ࠸⥆࠸࡚࠸ࡿᅜ㝿㐃ᦠάື࡛ࡍࠋ࠾஫࠸ࡢ࡜ࡇࢁ࡛ࠊ࠶
ࡕࡽ࡟⾜ࡗࡓࡾࡇࡕࡽ࡟⾜ࡗࡓࡾࡋ࡞ࡀࡽࡸࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࢆ⥆ࡅ࡚ࡁ࡚࠸ࡲࡍࠋ ᫖ᖺᗘ࡟㝈ࡗࡓ࠾ヰࢆࡋࡲࡍ࡜ࠊEMBL ࡛ PhD ࡢᏛ⏕ࡀ୺ദࡋ࡚㛤ദࡍࡿ EMBLࠕPhD ࢩ࣏ࣥࢪ࣒࢘ࠖࡀ࠶ࡾࡲࡍࠋࡑࡇ࡟ࠊᇶ⏕◊࡟࠸ࡿ኱Ꮫ㝔⏕ࠊ୺࡟⥲◊኱⏕࡜ඹྠ฼⏝࡛᮶࡚ࡶࡽࡗ࡚࠸ࡿ኱Ꮫ㝔⏕ࢆὴ㐵ࡋ࡚ࠊᐇ㝿࡟ᙼࡽࡢ◊✲ࢆⓎ⾲ࡋ࡚㆟ㄽࡋ࡚ࡃࡿ࡜࠸࠺ࡇ࡜ࢆ
᫖ᖺࡣ୍␒኱ࡁ࡞࢖࣋ࣥࢺ࡜ࡋ࡚⾜࠸ࡲࡋࡓࠋࡑࡢὴ㐵⮬㌟ࡣ㸱ᖺ๓࡟⥆࠸࡚㸱ᅇ┠࡞ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ௒ᅇࡣ኱Ꮫ㝔⏕ࢆ୍ே୍ேࡤࡽࡤࡽ࡟ EMBL ࡢ◊✲ᐊ࡟ὴ㐵ࡋ࡚ࠊࡑࡇ࡛ࢭ࣑
ࢼ࣮ࢆࡋ࡚ࡃࡿ࡜࠸࠺ࡼ࠺࡞⤒㦂ࡶᣢࡓࡏ࡚࠸ࡓࡔࡃࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ
 ࡑࡢ௚࡟ࡶ࠿࡞ࡾಶูࡢ࡛ࣞ࣋ࣝࡢ EMBL ࡜ࡢ஺ὶࡣࢧ࣏࣮ࢺࡋ࡚࠸࡚ࠊEMBL ࡛ࡢࢩ࣏ࣥࢪ࣒࢘࡟⾜ࡃሙྜࡢࢧ࣏࣮ࢺࠊ࠶ࡿ࠸ࡣ෸ᩍᤵࡢඛ⏕࡟㸯ே⾜ࡗ࡚࠸ࡓࡔ࠸ࡓࡢ࡛ࡍࡀࠊ
ᙼࡣ᳜≀ࡢ࢖࣓࣮ࢪࣥࢢࢆࡉࢀ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࡢඹྠ◊✲࡜ࢭ࣑ࢼ࣮➼ࡢ஺ὶ࡜࠸࠺ࡇ࡜࡛⾜࠿ࢀࡲࡋࡓࠋࡇࡢࡼ࠺࡞ࠊ࠸ࢁ࠸ࢁ࡞ࢳࣕࣥࢿ࡛ࣝ EMBL ࡜ࡣ஺ὶࢆ⥆ࡅ࡚࠸ࡲࡍࠋ ࡑࢀ࠿ࡽࠊࡇࢀࡣࡶ࠺ࡔ࠸ࡪ๓࡟ࡣ࡞ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊEMBL ࠿ࡽᑟධࡋࡓ DSLM㸦ගࢩ࣮ࢺᆺ㢧ᚤ㙾㸧ࢆᇶ⏕◊࡟ࡶᑟධࡋ࡚᭱㐺໬ࢆ㐍ࡵࡿ࡜࡜ࡶ࡟ࠊᐇ㝿ࡢࣂ࢖࢜ࣟࢪ࣮ࡢ◊✲ࢆ㐍ࡵ࡚࠸ࡲࡍࠋ᫖ᖺᗘ࡟㛵ࡋ࡚ࡣ㸰ᮏࡢㄽᩥ࡜ࡋ࡚ሗ࿌ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ

− 71 − 㸱␒┠࡟㛵ࡋ࡚ࠊࢸ࣐ࢭࢡࡣࢩ࣏࣮ࣥ࢞ࣝࡢ◊✲ᡤ࡛ࡍࠋࡑࢀ࠿ࡽࠊࢻ࢖ࢶࡢࢣࣝࣥ࡟࠶
ࡿ࣐ࢵࢡࢫࣉࣛࣥࢡࡢ᳜≀⫱✀Ꮫ◊✲ᡤ࡜ࡢᅜ㝿ඹྠ◊✲࡟ࡘ࠸࡚࡛ࡍࠋࡇࢀࡣᒸ⏣๓ᡤ㛗ࡢ࡜ࡁ࡟ጞࡲࡗࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊ᳜≀⛉Ꮫࢆ୰ᚰ࡟ᇶ⏕◊࡜ేࡏ࡚୕ࡘࡢ◊✲ᡤ࡛ྜྠࡢ
ࢩ࣏ࣥࢪ࣒࢘ࢆ⾜࠸࡞ࡀࡽඹྠ◊✲ࢆᐇ᪋ࡋ࡚࠸ࡇ࠺࡜࠸࠺ࡇ࡜ࢆࡸࡗ࡚࠸ࡲࡍࠋ௒ࡲ࡛࡟
㸲ᅇࢩ࣏ࣥࢪ࣒࢘ࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
 ᫖ᖺᗘ࡟㛵ࡋ࡚ࡣࠊࡕࡻ࠺࡝ᖺᗘࡢቃ┠࡛ࠊࢩ࣏ࣥࢪ࣒࢘ࡣ⾜ࢃ࡞࠿ࡗࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊ
MPIPZ ࡟ᇶ⏕◊࠿ࡽ⾜࠿ࢀࡓຓᩍࡢඛ⏕ࡀ◊✲⤖ᯝࢆᏛ⾡㞧ㄅࡢㄽᩥ࡜ࡋ࡚Ⓨ⾲ࡉࢀࡿ࡜࠸࠺ࡼ࠺࡞ᡂᯝࢆᚓ࡚࠸ࡲࡍࠋࡓࡔࠊඛ࡯࡝ᡤ㛗࠿ࡽࡶ࠶ࡾࡲࡋࡓࡀࠊࡇࡢࡼ࠺࡞ᙧ࡛⥆ࡅ࡚࠸ࡅࡿࡢ࠿࡝࠺࠿ࠊ࡝࠺࠸ࡗࡓᙧࡀ࠸࠸ࡢ࠿࡜࠸࠺ࡇ࡜ࡣࠊ௒ᑡࡋ᳨ウࡋ࡚࠸ࡲࡍࡀࠊ௒
ᖺᗘ࡟➨㸳ᅇࡢࢩ࣏ࣥࢪ࣒࢘ࢆࢻ࢖ࢶ࡛㛤ദࡋ࡚࠸ࡓࡔࡅࡿࡼ࠺࡞ヰࢆࡋ࡚࠸ࡿ࡜ࡇࢁ࡛ࡍࠋ 㸲␒࡟⾜ࡃ๓࡟୍ࡘࠊ᫖ᖺᗘࡢάືࡣ࡞࠿ࡗࡓࡢ࡛グධࡋ࡚࠸ࡲࡏࢇ࡛ࡋࡓࡀࠊඛ࡯࡝ࡢ
ヰ࡟㛵㐃ࡍࡿࡢ࡛ࡈሗ࿌ࡋࡓ࠸ࡢࡀࠊᅜ㝿ࣉࣛࢡࢸ࢕࢝ࣝࢥ࣮ࢫ࡜࠸࠺ࡶࡢ࡛ࡍࠋࡇࢀࡣᅜ
㝿㐃ᦠάືࡢ୍ࡘ࡜ࡋ࡚ᇶ⏕◊࡛ࡣ⾜ࡗ࡚࠸ࡲࡍࡅࢀ࡝ࡶࠊࡇࢀࢆ୍᫖ᖺᗘ࡜௒ᖺᗘ࡟⾜࠸ࡲࡍࠋ௒ᖺᗘࡢணᐃࡢࡶࡢࢆලయⓗ࡟࠾ヰࡋࡋࡲࡍ࡜ࠊ࣓ࢲ࢝ࠊࢮࣈࣛࣇ࢕ࢵࢩࣗࢆ୰ᚰ࡜
ࡋࡓᑠᆺ㨶㢮ࡢࢤࣀ࣒⦅㞟࡛ࡍࠋ๓ᅇࡣ TALEN ࡔࡗࡓࡢࡀࠊ௒ᅇࡣ CRISPR ࡢ⣔࡟⛣ࡗ࡚ࡁ࡚࠸ࡲࡍࡅࢀ࡝ࡶࠊࡑࢀࡢࡲࡉ࡟ࢸࢡࢽ࢝ࣝࢥ࣮ࢫࢆ㛤ദࡋ࡚࠸ࡲࡍࠋ௒ᖺ㛤ࡃࡶࡢࡣᇶ
⏕◊࡛⛅࡟  ᪥㛫ࡢࢫࢣࢪ࣮࡛࣓ࣗࣝࢲ࢝࡜ࢮࣀࣃࢫ࡜ࢮࣈ࡛ࣛ㛤ദࡋࡲࡍࠋ
㛵㐃ᢏ⾡࡜ࡋ
࡚ࡢ࢖࣓࣮ࢪࣥࢢࠊ⢭Ꮚ෾⤖ಖᏑ࡞࡝ࢆేࡏࡓࠊᑠᆺ㨶㢮ࢆᢅ࠺ࢸࢡࢽࢵࢡ࡜ࡋ࡚ࡣ඘ᐇࡋ
ࡓࢥ࣮ࢫࢆ㛤ࡃணᐃ࡛ࡍࠋ ྡ࡯࡝ࡢཷㅮ⏕ࢆᅜ㝿ⓗ࡟ເࡗ࡚ࠊ኱య㸯ᖺ࠿㸰ᖺࡄࡽ࠸ࡢ㛫㝸࡛㛤ദࡋ࡚࠸ࡲࡍࠋඛ࡯࡝ࡢඹྠ฼⏝࡜࠸࠺ᯟ࡛ࡢእᅜேࡢཷࡅධࢀࡣ⌧᫬Ⅼ࡛ࡣ࠶ࡲࡾ
࡞࠸࡜࠸࠺ࡇ࡜ࡣ☜࠿࡞ࡢ࡛ࡍࡀࠊࡇ࠺࠸ࡗࡓᙧ࡛◊✲㠃࡛ᐇ㝿࡟ᾏእࡢ᪉ࠎ࡟㈉⊩ࢆࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࡋࠊࢿࢵࢺ࣮࣡ࢡࢆసࡗ࡚࠸ࡿ࡜⌮ゎࡋ࡚࠸ࡲࡍࠋ
 ᭱ᚋࡢ㸲␒┠࡟࡞ࡾࡲࡍࡅࢀ࡝ࡶࠊ࣎ࢺ࣒࢔ࢵࣉᆺᅜ㝿㐃ᦠࡢ❧ࡕୖࡆ࡟ࡘ࠸࡚ㄝ᫂ࡋࡲ
ࡍࠋࡇࢀ࡟ࡘ࠸࡚ࠊ᫖ᖺᗘ㆟ㄽࡋ࡚ࠊࡇ࠺࠸࠺᪉㔪࡛࠸ࡅ࡞࠸ࡔࢁ࠺࠿࡜⪃࠼ࡲࡋࡓࠋඛ࡯
࡝㛗㇂ඛ⏕࠿ࡽࡶ࠾ヰࡀ࠶ࡾࡲࡋࡓࡀࠊᡤ඲య࡜ࡋ࡚࡝࠺࠸࠺᪉ྥᛶࢆฟࡋ࡚࠸ࡃ࠿࡜࠸࠺
ၥ㢟ࡣ㠀ᖖ࡟኱஦࡛࠶ࡾࠊ
ᡤ㛗ࡶ࠾ࡗࡋࡷࡗࡓࡼ࠺࡟ࠊ
ࡑ࠺࠸ࡗࡓࣉࣞࢵࢩ࣮ࣕࡶ࠶ࡾࡲࡍࠋ
ࡑࡢ୍᪉࡛ࠊࡸࡣࡾ୍ே୍ேࡢ◊✲⪅ࡀࣔࢳ࣮࣋ࢩࣙࣥࢆᣢࡗ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡃ࡜࠸࠺ࡇ
࡜ࡀ㠀ᖖ࡟㔜せ࡛࠶ࡿ࡜࠸࠺ࡇ࡜࡛ࠊ࠸࠿࡟ࡑࡇࡢ᪉ྥࢆ୍⮴ࡉࡏ࡚࠸ࡅࡿ࠿࡜࠸࠺࡜ࡇࢁ
ࡀ㠀ᖖ࡟㔜せࡔࢁ࠺ࠊᅜ㝿㐃ᦠ࡞࡝࡟࠾࠸࡚ࡶࡲࡉ࡟ࡑ࠺ࡔࢁ࠺࡜࠸࠺ࡇ࡜ࢆ⪃࠼ࡲࡋࡓࠋ ⌧ᅾࡸࡗ࡚࠸ࡿ㐃ᦠάືࡣࠊ࠶ࡿព࿡࡛ࢺࢵࣉࢲ࢘ࣥᆺ࡜࠸࠺࠿ࠊඛ࡟᪉㔪ࢆỴࡵ࡚ࠊࡑࢀ࡟ྜࢃࡏࡿ࡜࠸࠺࠿ࠊࡑࢀ࡟ྜ࠺◊✲ࡢ᪉ྥࢆᶍ⣴ࡍࡿᙧࡢ㐃ᦠࢆ⤌ࢇ࡛ࡁࡓ࡜ᛮ࠸ࡲࡍ
ࡅࢀ࡝ࡶࠊᚲࡎࡋࡶ࠺ࡲࡃ࠸࠿࡞࠸⌧≧ࡶ࠶ࡗࡓ࡜࠸࠺ࡢࡶഇࡽࡊࡿ࡜ࡇࢁ࡛࠶ࡾࡲࡍࠋ㐪ࡗࡓ᪉ྥ࡛ᅜ㝿㐃ᦠࢆ⤌ࢇ࡛࠸ࡅ࡞࠸࠿ࠊᐇ㝿࡟ಶࠎࡢ◊✲ᐊࡀ⾜ࡗ࡚࠸ࡿࠊ࠶ࡿ࠸ࡣࡇࢀ
࠿ࡽ⾜࠸ࡓ࠸࡜ᛮࡗ࡚࠸ࡿ◊✲࡟ᇶ࡙࠸࡚ࠊࡑࢀࢆ⫱࡚࡚࠸ࡃ࡜࠸࠺ᙧ࡛ᡤ࡜ࡋ࡚ࢧ࣏࣮ࢺ

− 72 −

ࡋ࡚࠸ࡁ࡞ࡀࡽࠊࡑࡇ࠿ࡽ᭱⤊ⓗ࡟ࡣᶵ㛵㛫㐃ᦠ࡟ࡘ࡞ࡀࡗ࡚࠸ࡗ࡚ࠊࡑࢀࢆ኎ࡾ≀࡟࡛ࡁࡿࠊ᥈ࡾฟࡏࡿࡼ࠺࡞ᙧࡢ㐃ᦠάື࡟ࡋ࡚࠸ࡅ࡞࠸࠿ࠊࡑࡕࡽ࡟ᑡࡋ㔜ᚰࢆ⛣ࡋ࡚࠸ࡃࡢࡣ
࡝࠺ࡔ࡜࠸࠺㆟ㄽࢆ⾜࠸ࡲࡋࡓࠋ
 ௒ᖺᗘࡣࡶ࠺ࢫࢱ࣮ࢺࡋ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊ㸳௳࡯࡝ࡢྛ◊✲ᐊ࡛ࣞ࣋ࣝࡢᅜ㝿ඹྠ◊✲ࢆࢧ࣏࣮ࢺࡋ࡚ࠊேࡢ஺ὶࡸᐇ㝿ࡢ◊✲ࢆࢧ࣏࣮ࢺࡋ࡞ࡀࡽࠊ௒ࡈㄝ᫂ࡋࡓ᪉ྥࢆ┠ᣦࡋ࡚࠸ࡃ࡜࠸࠺ࡇ࡜ࢆ⪃࠼࡚ࠊࡋࡤࡽࡃ⥆ࡅ࡚ࡳ࡚ࠊᚑ᮶ᆺࡢᅜ㝿㐃ᦠ࡜ࡢ㸰ᮏ❧࡚࡛࠸ࡇ࠺࡜⪃࠼࡚࠸ࡲࡍࠋ㸦すᮧ㸧 ᗈሗ࡜࢔࢘ࢺ࣮ࣜࢳάື࡟㛵ࡋ࡚⚾ࡢ᪉࠿ࡽ⡆༢࡟ࡈㄝ᫂࠸ࡓࡋࡲࡍ㸦㈨ᩱ㸯3㸧ࠋ ᗈሗࡢ᪉࡜ࡋ࡚ࡣᇶ♏⏕≀Ꮫ◊✲ᡤࡢ࣮࣒࣮࣍࣌ࢪࢆ࠿࡞ࡾᩚഛࡋࡓ࡜࠸࠺ࡇ࡜࡜ࠊ᝟ሗ
Ⓨಙࢧ࢖ࢺ࡜ࡋ࡚ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ࢙࢘ࣈ࣐࢞ࢪࣥࢆసࡾࡲࡋࡓࠋࡲࡓࠊ኱Ꮫ㝔⏕➼࡟ྥࡅ࡚ࢶ࢖ࢵࢱ࣮➼ࡢ SNS ࢆ౑ࡗ࡚᝟ሗⓎಙࢆ⾜ࡗ࡚࠸ࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊ◊✲ᡤࡢ୍⯡බ㛤ࢆ㸱ᖺ࡟୍ᗘᒸᓮᆅ༊࡛ྛ◊✲ᡤࡀᣢࡕᅇࡾ࡛⾜ࡗ࡚࠾ࡾࡲ
ࡍࡀࠊ᫖ᖺࡣᇶ♏⏕≀Ꮫ◊✲ᡤࡢ␒࡟࡞ࡾࡲࡋ࡚ࠊ ᭶㸳᪥࡟ࠕయឤ㸟᭱ඛ➃ࣂ࢖࢜ࡢୡ⏺ࠖ࡜࠸࠺ࢸ࣮࣐࡛㛤ദࡋࡲࡋࡓࠋࡑࡢ᮶ሙ⪅ࡀ  ே࡛ࡋࡓࠋ
 ࡲࡓࠊࣉࣞࢫ࣮ࣜࣜࢫࡀ᭱ึࡢᏛ⾡◊✲ࡢ࡜ࡇࢁ࡛ฟ࡚࠾ࡾࡲࡍࡅࢀ࡝ࡶࠊ୺せ࡞◊✲࡟㛵ࡋ࡚ࡣ  ௳ࡢࣉࣞࢫ࣮ࣜࣜࢫࢆࡋࡲࡋࡓࠋ ༳ๅ≀࡟㛵ࡋ࡚ࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢせぴ࡜࢔ࢽࣗ࢔࣏࣮ࣝࣞࢺࡣẖᖺฟࡋ࡚࠾ࡾࡲࡍࡅ
ࢀ࡝ࡶࠊࡑࢀࢆห⾜ࡋࡓ࡜࠸࠺ࡇ࡜࡜࡜ࡶ࡟ࠊ࠾ᡭඖ࡟࠶ࡿࠗᇶ♏⏕≀Ꮫ◊✲ᡤ࣐࢞ࢪࣥ࠘
ࢆࠊ ᖺ㸱᭶࡟➨㸯ྕࢆฟࡋࡲࡋࡓࠋ◊✲⪅ྥࡅ࡟ࡣ࡞ࡗ࡚࠾ࡾࡲࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺
࣐࢞ࢪࣥࢆసࡗ࡚ࠊࡇࢀࢆ௒ᚋ㐍ࡵ࡚࠸ࡃ࡜࠸࠺ࡇ࡜࡟࡞ࡗ࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊ⌮⛉ᩍ⫱࡬ࡢ༠ຊ࡛ࡍࠋ≉࡟ᒸᓮ㧗ᰯࡢࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࣁ࢖ࢫࢡ࣮ࣝάື
࡬ࡢ༠ຊ࡜ࠊ
ࠕ⛉Ꮫ୕࿡ LQ ࠶࠸ࡕࠖ࡟㛵ࡋ࡚ࡢᐇ㝿ࡢⓎ⾲ࡢᣦᑟ➼ࢆ⾜ࡗ࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊ኱Ꮫ⏕ྥࡅࡢᗈሗ࢖࣋ࣥࢺ࡜࠸࠺ࡇ࡜࡛ࠊ
ࠕ኱Ꮫ⏕ࡢࡓࡵࡢኟࡢᐇ⩦࡛ࠖࡍࠋࡇ
ࢀࡣࡶ࠺ᑡࡋᚋ࡟኱Ꮫ㝔⏕ࡢ⋓ᚓ࡜࠸࠺࡜ࡇࢁ࡛ࡶฟ࡚ࡁࡲࡍࡅࢀ࡝ࡶࠊጞࡵ࡚㸱ᖺࡄࡽ࠸ࡓࡘ࡛ࡋࡻ࠺࠿ࠋ᫖ᖺࡣ  ྡࡢᏛ㒊Ꮫ⏕ࡀཧຍࡋ࡚࠾ࡾࡲࡍࠋࡇࡢࡇ࡜࡛኱Ꮫ㝔ࢆཷ㦂ࡍࡿேࡀ࠿࡞ࡾቑ࠼࡚ࡁ࡚࠸ࡿ࡜⚾࡝ࡶࡣ⪃࠼࡚࠾ࡾࡲࡍࠋ
 ࡜࠸࠺ࡇ࡜࡛ࠊᅜ㝿㐃ᦠ࡜ᗈሗ࡟㛵ࡋ࡚௒ࡢ≧ἣࢆ࠾ヰࡋࡋࡲࡋࡓࡅࢀ࡝ࡶࠊࡇࢀ࡟㛵ࡋ࡚ࡈពぢࠊࡈ㉁ၥ➼ࢆ࠾ఛ࠸ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࡀࠊ࡝࠺࡛ࡋࡻ࠺࠿ࠋ
㸦㛗㇂㸧 ࡇ࠺࠸࠺ᙧࡢᅜ㝿㐃ᦠࡣάⓎ࡟ࡸࡗ࡚࠾ࡽࢀࡿࡋࠊ࠸ࢁ࠸ࢁ࡞ྛ኱Ꮫ࡛ࡶࡸࡗ࡚
࠸ࡿࡇ࡜ࡔࢁ࠺࡜ᛮ࠺ࡢ࡛ࡍࠋ◊✲⤌⧊࡜ࡶ㛵ࢃࡿࢃࡅ࡛ࡍࡀࠊእᅜே PI ࡢ◊✲ᐊࡀ୍ࡘࡶ
࡞࠸࡜࠸࠺ࡇ࡜ࡀ┠࡟ࡘࡁࡲࡍࠋᅜ㝿㐃ᦠ࡜࠸࠺ᙧ࡛኱ኚ᭷ຊ࡞࡜ࡇࢁ࡜༠ᐃࡶ⤖ࢇ࡛ࡸࡗ࡚࠾ࡽࢀࡿ࡜࠸࠺ࡇ࡜ࡣࠊᡓ␎ⓗ࡟ࡑ࠺࠸࠺࡜ࡇࢁࡢ᪉ࢆ౛࠼ࡤ⊂❧෸ᩍᤵ࡜࠿ࡑ࠺࠸࠺ࣞ

− 73 −

࡛࣋ࣝࡇࡕࡽࡶ᮶࡚࠸ࡓࡔࡃࠊࡑ࠺࠸࠺◊✲ࢢ࣮ࣝࣉ࡜ࡋ࡚ࡢᐇ㝿ࡢே஦஺ὶࠊ࠶ࡿ࠸ࡣ⤌⧊஺ὶ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࢆࡉࢀࢀࡤ࡝࠺࡛ࡋࡻ࠺࠿ࠋࡴࡋࢁᩥ⛉┬࠿ࡽせㄳࡉࢀ࡚࠸ࡿࡼ࠺
࡞ᒁ㠃ࡔࢁ࠺࡜ᛮ࠺ࡢ࡛ࡍࡀࠋ㸦すᮧ㸧 ࡇࢀ࡟㛵ࡋ࡚ࠊ㐣ཤࡢ୍⯡ⓗ࡞ே஦ࡢ࡜ࡇࢁ࡛ࠊᇶ⏕◊ࡢே஦࡟㛵ࡋ࡚ࡣ඲࡚ᅜ
㝿බເࡋ࡚࠾ࡾࡲࡍࠋ
ࠕNatureࠖ࡟ᐉఏࢆฟࡋ࡚ເ㞟ࡋ࡚࠸ࡿࡢ࡛ࡍࠋࡶࡕࢁࢇᅜ⡠ࡀእᅜࡢேࡶ࠸ࡲࡍࡀࠊ᭱ᚋࡢ㑅⪃ࡢ࡜ࡇࢁࡲ࡛ࡣ࡞࠿࡞࠿ṧࡽ࡞࠸≧ἣ࡛ࡍࠋ࡛ࡍ࠿ࡽࠊࡑࢀ࡟ྥ
ࡅ࡚ࠊ≉ู࡟እᅜேᩍဨࢆධࢀࡼ࠺࡜࠸࠺ࡇ࡜ࡣ௒ࡢẁ㝵࡛ࡣලయⓗ࡟⾜ࡗ࡚࠾ࡾࡲࡏࢇࡅ
ࢀ࡝ࡶࠊ௒ᅇࡢ◊✲ຊᙉ໬ࡢ URA ࡢ୰࡛ࡣࠊᐇ㝿࡟እᅜேࡢࣃ࣮ࢭࣥࢸ࣮ࢪࢆ࠶ࡿ⛬ᗘୖࡆ࡚࠸ࡃࡇ࡜ࡀබ⣙ࡉࢀ࡚࠸ࡿ࡜࠸࠺≧ἣ࡟࡞ࡗ࡚࠾ࡾࡲࡍࡢ࡛ࠊᑐᛂࡣࡋ࡚࠸࠿࡞࠸࡜࠸
ࡅ࡞࠸ࡢ࠿࡜ࡣ⪃࠼࡚࠾ࡾࡲࡍࠋᒣᮏඛ⏕ࡢ᪉࠿ࡽࡈពぢࢆࠋ㸦ᒣᮏ㸧 ⚾ࡣே஦࡟ࡘ࠸࡚Ṕྐⓗ࡞ࡇ࡜ࢆᢕᥱࡋ࡚࠸࡞࠸ࡢ࡛ࡍࡀࠊබເࡋࡓ࡜ࡁ࡟ᛂເ
ࡋ࡚ࡃࡿእᅜேࡢ๭ྜࡣࠊ㔝⏣ඛ⏕ࡣࡈᏑࡌ࡛ࡍ࠿ࠋ
㸦㔝⏣㸧 㐣ཤࡢᩍᤵࡢ࡜ࡁࡣ㸱㹼㸲ྡࡄࡽ࠸ࡔࡗࡓ࡜ᛮ࠸ࡲࡍࡡࠋ ࡢ࠺ࡕࡢ㸱ྡࡄࡽ࠸ࠋ㸦ᒣᮏ㸧 㸱㹼㸲ྡࡀእᅜே࡛ࡍࡡࠋࡇࡢ㛫ࡢዪᛶࡢ෸ᩍᤵࡢ࡜ࡁࡶእᅜ࠿ࡽࡢᛂເࡣ࠶ࡾ
ࡲࡋࡓࡀࠊᑂᰝ࡟ࡣṧࡽ࡞࠿ࡗࡓ࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍࠋ௒ࡢ࡜ࡇࢁࡣศࡅ㝸࡚࡞ࡃぢ࡚࠸ࡿ࡜࠸࠺࡜ࡇࢁ࡛ࠊ≉࡟እᅜேࡔ࠿ࡽඃ㐝ࡋࡼ࠺࡜࠸࠺㆟ㄽࡣฟ࡚࠸࡞࠸࡛ࡍࡡࠋ
㸦᳃㸧 ࡑࢀ࡟㛵ࡋ࡚ࠊ࠺ࡕࡢ኱Ꮫ࡛ࡶ
ၥ㢟࡞ࡢ࡛ࡍࡀࠊᮏᙜ࡟ࢺࢵࣉࣞ࣋ࣝࡢ
ᩍᤵࢆ㞠⏝ࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࡢ࡛ࡍࡀࠊ
ࢧ࣮ࣛࣜࡀ඲↛㐪࠺࡜࠸࠺ၥ㢟ࡀ࠶ࡾࡲࡍࠋ౛࠼ࡤࠊ㠀ᖖ࡟᭷ຊ࡞᪉ࠊࡑࡢ᪉ࡣ
᪥ᮏே࡞ࡢ࡛ࡍࡀࠊࡶ࠺ࢸࢽࣗ࢔ࢆྲྀࡿࠊ
ྲྀࡽ࡞࠸࡜࠸࠺≧ἣ࡛࢔࣓ࣜ࢝࡟࠸ࡽࡗ
ࡋࡷࡗ࡚ࠊࡇࡕࡽ࠿ࡽࣉࣟࣇ࢙ࢵࢧ࣮ࡢ
⫋ࢆ࢜ࣇ࢓࣮ࡋࡓࡢ࡛ࡍࠋ࢜ࣇ࢓࣮ࡋ࡚
࠿ࡽࠊ㠀ᖖ࡟ヲࡋ࠸ࢧ࣮ࣛࣜࡢヰ࡟࡞ࡾࡲࡍࡼࡡࠋࡑࡇ࡛ዟࡉࢇࡀ࢔࣓ࣜ࢝ே࡛ࠊ
࠿ࢇ࠿ࢇ࡟ᛣࡾࠊ࠶ࡾᚓ࡞࠸࡛ࡋࡻ࠺࡜
࠸࠺ࡇ࡜࡟࡞ࡾࡲࡋ࡚ࠊᣄྰࡉࢀࡲࡋࡓࠋᐇ㝿࡟ࡣࣉࣟࣇ࢙ࢵࢧ࣮ࡢࢧ࣮ࣛࣜࡀ࢔࣓ࣜ࢝࡜ឤぬࡀ඲↛㐪࠺ࡢ࡛ࡍࡼࡡࠋຓᩍࡢ᪉࡛ࡶࡑ࠺࠸࠺ࡇ࡜ࡀᐇࡣ࠶ࡾࡲࡋ࡚ࠊຓᩍࡢ࡛ࣞ࣋ࣝ
ࡶ༙ศ࡟࡞ࡗ࡚ࡋࡲ࠺ࡢ࡛ࡍࠋ࡛ࡍ࠿ࡽࠊ
ࠕ࠼࠼ࡗࠖ࡜࠸࠺ࠋࡔ࠿ࡽࠊ᭱ึࡢ࡜ࡁࡣࢧ࢖࢚ࣥ
ࢸ࢕ࣇ࢕ࢵࢡ࡞ヰ࡛ࠊ࠶ࡿ࡜ࡇࢁࡲ࡛⾜ࡃࡢ࡛ࡍࡀࠊ࢖࢚ࢫࢆࡶࡽࡗ࡚ࡶࠊࡑࡇ࠿ࡽࢧࣛࣜ

− 74 −

࣮ࡢ⣽࠿࠸ヰ࡟࡞ࡗࡓ࡜ࡁ࡟ࠕ࠼࠼ࡗࠖ࡜࠸࠺ࡢࡀఱᅇ࠿⥆ࡁࡲࡋࡓࠋࡑࡇࡢၥ㢟ࢆゎỴࡋ࡞࠸࡜ࠊእᅜேࡢඃࢀࡓ᪉ࠊእᅜ࡟࠸ࡿ᪉ࡣ᥇ࢀ࡞࠸࡜࡞ࡗ࡚࠾ࡾࡲࡍࠋࡑࢀࡣࡍࡈ࠸ၥ㢟࡛ࠊ࡝࠺ࡋࡼ࠺ࡶ࡞࠸࡛ࡍࡡࠋ࠺ࡕࡢ኱Ꮫ඲యࡣ࡜ࡶ࠿ࡃࠊᑡ࡞ࡃ࡜ࡶ࠺ࡕࡢ㒊⨫ࡣࡑࡇࡢቨࢆ㉺࠼ࡽࢀ࡞࠸࡜࠸࠺≧ἣ࡟࡞ࡗ࡚࠸ࡲࡍࠋ
 ࡑࡢࣞ࣋ࣝ࡞ࡢ࡛ࡍࡡࠋ࢜ࣇ࢓࣮ࡋ࡚ྜពࡀ࠶ࡗ࡚ࡶࠊࡑࡇ࡟ᐇ㝿࡟⏕ά࡛ࡁ࡞࠸࡜࠸࠺
࠿ࠊ࠶ࡾᚓ࡞࠸࡜࠸࠺࠿ࠋ᪥ᮏேࡢ᪉ࡔ࡜ࠊᐇ㝿࡟༙ศ࡟࡞ࡗ࡚ࡶࠊ㸰㹼㸱ᖺ࡛᪥ᮏࡢ⏕ά࡟័ࢀ࡚࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜ࡀ㐣ཤ࡟ࡣ࠶ࡗࡓࡢ࡛ࡍࡀࠊᾏእࡢ᪉ࡔ࡜ࠊࡶ࠺඲↛࠶ࡾᚓ࡞࠸࡜࠸࠺ឤࡌ࡟࡞ࡗ࡚ࡋࡲ࠺࡜࠸࠺ࡇ࡜ࡀ࠶ࡾࡲࡍࠋ
㸦㛗㇂㸧 ௒ࡣ⤥୚య⣔࡛ᖺಧไࡀ᥎ዡࡉࢀ࡚ࠊࡇࢀ࠿ࡽቑࡸࡋ࡚࠸࠿࡞࠸࡜࠸ࡅ࡞࠸ࢃࡅ
࡛ࡍࠋ࠸ࢃࡺࡿ㏥⫋㔠ࡢ✚ࡳୖࡆࡀ࡞࠸ࢃࡅ࡛ࡍ࠿ࡽࠊ᮶ࡽࢀࡿ᪉ࡀᐃᖺࡲ࡛࠸࡚ࡶ࣓ࣜࢵ
ࢺࡣ࡞࠸ࡢ࡛ࠊ㠀ᖖ࡟ὶືᛶࡀ㧗࠸ࠊࣇࢵࢺ࣮࣡ࢡࡀ㍍࠸ᙧ࡛㞠⏝ࡀ࡛ࡁࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ ࡑࢀ࠿ࡽࠊᖺಧไ࡟㛵ࡋ࡚ࡣࢃࢀࢃࢀࡢ⤥୚య⣔࡜ࡣูࡢ⤥୚య⣔࡛ࠊࡋ࠿ࡶ࣮࣎ࢼࢫࡢ
ᰝᐃ࡞࡝ࡶ㠀ᖖ࡟⮬⏤ᗘࢆᣢࡗ࡚࡛ࡁ࡚࠸ࡿࡢ࡛ࠊ኱㜰኱Ꮫ࡛ࡣ౛࠼ࡤ  ୓෇ࡲ࡛ࡣฟࡏ
ࡿ࡜࠸࠺ࡼ࠺࡞⤌⧊࡟ࡋ࡚࠸ࡿࡢ࡛ࡍࡀࠊࡑࢀ࡛ࡶࠊ࡞࠾࠿ࡘ᮶࡚ࡶࡽ࠼࡞࠸ࢣ࣮ࢫࡀ࠶ࡿ
ࡢࡣࠊ࠾ࡗࡋࡷࡿ࡜࠾ࡾ࡛ࡍࠋ
㸦᳃㸧 ࠶࠶ࠊࡑ࠺࡛ࡍ࠿ࠋ
㸦㛗㇂㸧 㸯൨෇࡜࠸࠺ࡇ࡜ࢆゝࢃࢀ࡚ࠊࡇࢀࡣ↓⌮࡜ゝࡗ࡚᩿ࡗ࡚࠸ࡿࢃࡅ࡛ࡍࡀࠊࡑࢀ
ࡀࡸࡣࡾྥࡇ࠺ࡢᖖ㆑ࡔࡑ࠺࡛ࡍࠋࡅࢀ࡝ࡶࠊᑡ࡞ࡃ࡜ࡶ⤥୚య⣔ࡢୖ࡛ࡣඹ῭⤌ྜဨ࡜ࡋ࡚ࣂࢵࢡ࢔ࢵࣉ࡛ࡁࡿ୰࡛ᖺಧไ࡛ࠊ࠿ࡘࡑ࠺࠸࠺≉ู⤥୚ࢆฟࡏࡿ࡜࠸࠺௙⤌ࡳࡀྍ⬟ࡔ࡜ᛮ࠸ࡲࡍࠋே௳㈝ࢆ㐠Ⴀ㈝஺௜㔠ࡢ⮬ศࡓࡕࡢศࢆ୰࡛ᣢࡕฟࡍぬᝅࡉ࠼࡛ࡁࢀࡤࠊ࠿࡞
ࡾࣇࣞ࢟ࢩࣅࣜࢸ࢕ࡣ࠶ࢁ࠺࠿࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ⮬↛⛉Ꮫ◊✲ᶵᵓࡶࡲࡉ࡟ྠࡌ≧ἣ࡛ࠊᖺಧไࡢไ㝈ࡀ㠀ᖖ࡟኱ࡁࡃ࡞ࡗ࡚࠸࡚ࠊ
ࡑࢀࢆྲྀࢀࡤ㠀ᖖ࡟ࡸࢀࡿ≧ἣ࡟ࡣ࡞ࡗ࡚ࡁ࡚࠾ࡾࡲࡍࠋ≉࡟ᑟධࡋࡓ࡜ࡁ࡟ኳᩥྎ࡞࡝࡛
ࡣࡑ࠺࠸࠺ேࢆ᥇ࡾࡓ࠸࡜࠸࠺ࡇ࡜ࢆゝࡗ࡚࠾ࡽࢀࡲࡋࡓࠋࡑ࠺࠸࠺࡜ࡁ࡟ၥ㢟Ⅼ࡜ࡋ࡚ฟࡓࡢࡣࠊඛ࡯࡝ࡢ᳃ࡉࢇ࡜ྠࡌࡼ࠺࡞ヰ࡛ࠊࡲࡎᩍဨࡣ᮲௳ࢆ㠀ᖖ࡟Ⰻࡃࡍࡿࠋࡑࢀ࡜ࡶ࠺
୍ࡘࡣࠊዟࡉࢇࡢാࡅࡿࡼ࠺࡞⎔ቃࡶᩚഛࡋ࡞࠸࡜࡞࠿࡞࠿㞴ࡋ࠸࡜࠸࠺ࡇ࡜࡛ࡍࠋ
ࡔ࠿ࡽࠊ࠸ࢁ࠸ࢁ࡞ၥ㢟ࡀຍࢃࡗ࡚࠸࡚ࠊ࡞࠿࡞࠿ᐇ⌧ࡋ࡚࠸࡞࠸࡜࠸࠺ࡇ࡜࡟࡞ࡗ࡚࠸ࡿࡢࡔࢁ࠺
࡜ᛮ࠸ࡲࡍࠋ
㸦ኴ⏣㸧 ࡛ࡶࠊࡑࢀࡣእᅜࡢ◊✲⪅ࡔࡅ࡛࡞ࡃ࡚ࠊ᪥ᮏே࡟ࡶࡑ࠺࠸࠺ࡇ࡜ࢆᖹ➼࡟ࡸࡗ࡚࠸ࡓࡔࡁࡓ࠸ࡢ࡛ࡍࡡࠋࡑࢀࡣࡸࡣࡾᩥ⛉┬࡟ࡐࡦࠋࡑࢀࡀᮏᙜࡢࢢ࣮ࣟࣂࣝ໬࡜࠸࠺ࡇ
࡜ࡔ࡜ᛮࡗ࡚࠸ࡲࡍࠋ
− 75 −㸦すᮧ㸧 ࡞ࡿ࡯࡝ࠊࡑ࠺࡛ࡍࡡࠋ㸦㛗㇂㸧 ࡑࢀ࡜ࡶ࠺୍ࡘࡣࢡࣟࢫ࢔࣏࢖ࣥࢺ࣓ࣥࢺไᗘࡀ㉮ࡗ࡚࠸ࡿࢃࡅ࡛ࡍࠋ
࡛ࡍ࠿ࡽࠊ
እᅜே PI ࢆ࿧ࡪ࡜ࡁ࡟ࠊ༙ᖺࡣࡇࡇ࡛ࠊṧࡾࡢ༙ᖺࡣඖࡢ⤌⧊࡛࡜ࠊ⾜ࡗࡓࡾ᮶ࡓࡾࡋ࡞ࡀ
ࡽࠊࡑࡋ࡚ᐇ㝿࡟ຓᩍࡸ≉௵◊✲ဨࡣᇶ⏕◊࡛ᖖ㥔ࡍࡿ࡜࠸࠺ࡼ࠺࡞ᙧ࡟ࡍࢀࡤࠊ⤥୚࡜ࡋ࡚ᣢࡕฟࡍ㒊ศࡣ࠺ࢇ࡜ῶࡗ࡚ࠊࡅࢀ࡝ࡶࠊ⤌⧊࡜ࡋ࡚ࡣࡑࡢேࡢ◊✲ᐊࡀ❧ࡕୖࡀࡗࡓ࡜
࠸࠺ᙧ࡟࡞ࡾࡲࡍࠋࢡࣟࢫ࢔࣏࢖ࣥࢺ࣓ࣥࢺไᗘࡶᑟධࡉࢀࡓࡽࠊ㠀ᖖ࡟ࣇࢵࢺ࣮࣡ࢡࡀ㍍
࠸㞠⏝ࡀྍ⬟࡟࡞ࡿ࡜ᛮ࠸ࡲࡍࡡࠋ
㸦ᒣᮏ㸧 ୖᾏ࡞࡝ࡣ๭ྜࡑ࠺࠸࠺ไᗘࢆ౑ࡗ࡚ࡸࡗ࡚࠸ࡲࡍࡼࡡࠋ
㸦ኴ⏣㸧 ࠶࡜ࡣ୍ᐃࡢᩘࡀ᮶ࡿ࡜⮬ືⓗ࡟ධࡾࡸࡍࡃ࡞ࡗ࡚ࡃࡿࡳࡓ࠸࡞ࡇ࡜ࡀ࠶ࡾࠊᮾ
኱ࡢ⥲ྜᩥ໬◊✲⛉ࡣእᅜேᩍဨࡀ࠿࡞ࡾከ࠸࡛ࡍࠋ
㸦ᒣᮏ㸧 ࡑࢀࡣ≉࡟⤥ᩱࡀ࠸࠸ࢃࡅ࡛ࡣ࡞࠸㸽㸦ኴ⏣㸧 ඲↛⤥ᩱࡣᝏ࠸࡛ࡍࠋ࡛ࡶࠊ࠸ࡗࡥ࠸᮶ࡲࡍ࠿ࡽࠋ㸯๭௨ୖࡣእᅜே࡛ࡣ࡞࠸࡛
ࡋࡻ࠺࠿ࠋ᪥ᮏㄒࡀࡋࡷ࡭ࢀࡿࡼ࠺࡞ேࡶከ࠸࡛ࡍࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍ࠿ࠋ఍㆟ࢆ࡝࠺ࡍࡿࡢ࠿࡜ᛮࡗࡓࡢ࡛ࠊ㑇ఏ◊ࡶࡑ࠺࡛ࡋࡻ࠺ࡀࠊᩍᤵ
఍࡞࡝ࡣⱥㄒ࡛㸽㸦Ⲩᮌ㸧 ࢃࢀࢃࢀࡣᩍᤵࡔࡅࡢ఍㆟ࡣⱥㄒ࡛ࡸࡗ࡚࠸ࡲࡍࠋࡓࡔࠊ஦ົࡀධࡽࢀࡿ࡜ࡇࢁ
ࡣ᪥ᮏㄒ࡛ࡸࡗ࡚࠸ࡲࡍࠋ㸦すᮧ㸧 ஦ົࡀࡑ࠺࠸࠺ⱥㄒᑐᛂࡀ࡛ࡁࡿ࠿࡜࠸࠺࡜ࡇࢁࡲ࡛᮶࡚࠸ࡲࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ࡛ࡁࡿࡼ࠺࡟࠿࡞ࡾኚ࠼࡚ࡁࡲࡋࡓࠋ㸦すᮧ㸧 ኚࢃࡗ࡚ࡁ࡚࠸ࡿࡢ࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 ࡛ࡍ࠿ࡽࠊ᭩㢮ࡣ඲㒊ⱥㄒ࡟࡞ࡾࡲࡍࡋࠊ࣓࣮ࣝࡣᇶᮏⓗ࡟඲యࢆὶࢀࡿࡶࡢࡣ
ⱥㄒ࡛ࡍࠋ
㸦ᒣᮏ㸧 ௒ࠊ㑇ఏ◊࡟እᅜேᩍဨࡣఱே࠾ࡽࢀࡿࡢ࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 㑇ఏ◊ࡣᐇ㝿࡟ࡣእᅜ⡠ࡢᩍဨࡣ࠸࡞࠸ࡢ࡛ࡍࠋ࡛ࡍࡀࠊ᫂▼ࡉࢇ࡜࠸࠺᪥ᮏே
ࡢ᪉࡞ࡢ࡛ࡍࡀࠊ᏶඲࡟ྥࡇ࠺࡛ᩍ⫱ࡉࢀࡓ᪉࡛ࠊࡑࡢேࡣ᏶඲࡟ⱥㄒ࡜࠸࠺ࡇ࡜࡛ࡍࠋ㸦すᮧ㸧 ⱥㄒࡋ࠿࡛ࡁ࡞࠸ࡢ࡛ࡍ࠿ࠋ


− 76 −

㸦Ⲩᮌ㸧 ࣏ࢫࢻࢡ࡟እᅜேࡣࡶࡕࢁࢇ࠸ࡲࡍࡀࠋ࡛ࡍ࠿ࡽࠊ஦ົࢧ࢖ࢻࡢ㈇ᢸࡣ㝶ศቑ࠼ࡓ࡜ᛮ࠸ࡲࡍࡀࠊࡑࢀ࡟ᑐᛂࡉࢀ࡚ࡁࡓࡋࠊᮾ኱࡞࡝࡛ࡶࡑ࠺࡞ࡢ࡛ࡣ࡞࠸࡛ࡍ࠿ࠋ஦ົࢧ
࢖ࢻࡀᑐᛂࡋ࡚ࡇ࡞࠸࡜ࡸࡗ࡚࠸ࡅ࡞࠸ࡢ࡛ࡍࠋ
㸦ኴ⏣㸧 ࠸ࡸࠊࡑࡢయไࡀࡦ࡝࠸ࡢ࡛ࡍࠋᩍဨࡀࡸࡗ࡚࠸ࡿࡢ࡛ࡍࠋࡔ࠿ࡽࠊࣅࢨࢆྲྀࡿ
࡜ࡇࢁࡣ኱౑㤋࡟⾜ࡗ࡚ఱᗘࡶࡸࡾྲྀࡾࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࡢ࡛ࡍࡀࠊࡑࢀࡣᢸᙜᩍဨࡀࡍ
ࡿ࡜࠸࠺ࡇ࡜࡟࡞ࡗ࡚࠸࡚ࠊ
ࡑࢀࡣᮾ኱࡜ࡋ࡚ࡣ࠸࠿ࡀ࡞ࡶࡢ࠿࡜࠸࠺ヰ࡟ࡣ࡞ࡗ࡚࠸ࡲࡍࠋ
 ࢃࢀࢃࢀࡢ࡜ࡇࢁ࡛≉ู࡟ከ࠸ࡢࡣࠊ
ⱥㄒࡔࡅ࡛㸲ᖺ㛫ࡸࡿ PEAK ࡜࠸࠺ࢥ࣮ࢫࡀ࠶ࡗ࡚ࠊ
ࡑࢀࢆࡸࡗ࡚࠸ࡿࡶࡢ࡛ࡍ࠿ࡽእᅜࡢேࡀከ࠸ࡢ࡛ࡍࠋ࡛ࡶࠊ᪥ᮏㄒࡶࡋࡷ࡭ࢀࡿேࡶከ࠸
ࡶࡢ࡛ࡍ࠿ࡽࠊᩍဨഃࡶࡈࡃᬑ㏻࡟᪥ᮏㄒ࡛ࡸࡗ࡚࠸࡚ࠊᡃ៏ࡋ࡚㸰᫬㛫ࠊࡕࡷࢇ࡜እᅜࡢ
ேࡀ⪺࠸࡚࠸ࡿ࡜࠸࠺≧ែ࡛ࡍࠋ㸦すᮧ㸧 ᩍ⫱ࡣ᪥ᮏㄒ࡞ࡢ࡛ࡍ࠿ࠋ
㸦ኴ⏣㸧 ⱥㄒ࡛ࡍࠋࡅࢀ࡝ࡶ⤖ᵓࠊዟࡉࡲࡀ᪥ᮏே࡜࠿࡛ࠊ࠿࡞ࡾࡢ᪉ࡣ᪥ᮏㄒࡀ࠿࡞ࡾ
࡛ࡁࡿࡢ࡛ࡍࠋ୍ᐃࡢࡑ࠺࠸࠺ࢽ࣮ࢬࡢேࡀ࠸ࡽࡗࡋࡷࡿࡢ࡛ࠊ
ࡕࡷࢇ࡜㞟ࡲࡿ࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ㉁ၥࢆ᪥ᮏㄒ࡛Ꮫ⏕ࡀࡋ࡚ࡶ୍ᛂᑐᛂ࡛ࡁࡲࡍ࠿ࠋ
㸦ኴ⏣㸧 ࡛ࡁࡲࡍࠋ
㸦㛗㇂㸧 ᐇ㝿࡟ࡸࡿẼ࡟࡞ࢀࡤࠊඛ౛ࡣ኱Ꮫ࡟ࡣࡓࡃࡉࢇ࠶ࡿࢃࡅ࡛ࡍࠋWPI㸦World PremierInitiative㸧ࠊ࠶ࡑࡇࡣእᅜேᩍဨࡢᩘࢆ 㸣ࠊ࠶ࡿ࠸ࡣࡑ࠺࠸࠺ࡩ࠺࡟ࡋࢁ࡜࠸࠺ࡇ࡜࡛ᚲṚ࡟࡞ࡗ࡚㞟ࡵ࡚ࠋ
㸦ᒣᮏ㸧 ࠶ࡑࡇࡣ≉༊࡛ࡍ࠿ࡽࡡࠋ
㸦㛗㇂㸧 ◊✲⪅ࡀࢱ࣮࣮ࣥ࢜ࣂ࣮ࡍࡿᙧ࡟࡞ࡗ࡚ࡁ࡚࠸࡚ࠊㅖࠎࡢ᪥ᖖ⏕άࡶྵࡵࡓᨭ᥼
ࡢࣀ࢘ࣁ࢘ࡣ✚ࡳୖࡀࡗ࡚࠸ࡿࢃࡅ࡛ࡍࠋࡑࢀࡣᙜ↛㞃ࡍ࡭ࡁࡶࡢ࡛ࡣ࡞ࡃ࡚ࠊࢃࢀࢃࢀࡀ
ඹ᭷ࡋࡓࡽ࠸࠸࡜ᛮ࠺ࡢ࡛ࠊ㈨㔠ຊࡉ࠼࠶ࢀࡤࠊࡑ࠺࠸࠺ࡇ࡜ࡣྍ⬟࡛ࡍࠋ㸦ᒣᮏ㸧 ⮬↛⛉Ꮫ◊✲ᶵᵓ࡛ࡶ௵ᮇไࡢᑟධ࡟ࡘ࠸࡚㆟ㄽࡀ࠶ࡗࡓࡢ࡛ࡍࡀࠊ௒ࡣ௵ᮇไ
ࡢᩍဨ࡟ࡣᑡࡋ࢖ࣥࢭࣥࢸ࢕ࣈࢆ௜ࡅࡿ࡜࠸࠺ࡼ࠺࡞ヰࡀฟ࡚ࡁ࡚࠸ࡿࡢ࡛ࡍࠋࡓࡔࠊ࡯ࢇ
ࡢࢃࡎ࠿࡛ࡍࠋࡋ࠿ࡶࡑࢀ࡛ࠊ⮬⏤࡟ኚ࠼࡚ࡶ࠸࠸ࡢ࡛ࡍࠊ㧗࠸⤥୚ࡢேࡶ᥇ࢀࡲࡍ࡜ゝ࠺ࡢࡔࡅࢀ࡝ࡶࠊ⤖ᒁࠊせࡍࡿ࡟ࠊᖹᆒࡣࡕࡷࢇ࡜ᢲࡉ࠼࡚࠾ࡅ࡜࠸࠺ࢃࡅ࡞ࡢ࡛ࡍࠋ࡛ࡍ࠿
ࡽࠊࡑ࠺࠸࠺ேࢆసࢀࡤࠊṧࡾࡢேࡣୗࡀࡿࡋ࠿࡞࠸࡜࠸࠺ࠊࡑࢀ࡛࠸࠸ࡢࡔࡗࡓࡽ᥇ࢀࡿ
࡜࠸࠺ࡇ࡜࡛ࡍࠋ࠸࠸ேࢆసࡿࡢࡔࡗࡓࡽࠊᝏ࠸ேࡶࡕࡷࢇ࡜ホ౯࡛సࢀ࡜࠸࠺ヰ࡟࡞ࡗ࡚ࡋࡲ࠺ࡢ࡛ࡍࠋ

− 77 −㸦すᮧ㸧 ࡑ࠺࠸࠺ព࿡࡛ࡣࠊእᅜே㝈ᐃࡢබເࢆࡉࢀࡿ࡜࠸࠺ࡇ࡜࡛ࡍ࠿ࠋ
㸦㛗㇂㸧 ࡑ࠺࠸࠺࡜ࡇࢁࡶ࠶ࡾࡲࡍࡡࠋࢃࢀࢃࢀࡣ࡜࡚ࡶ࡛ࡁࡲࡏࢇࡀࠊ㈨㔠ຊࡀ࠶ࡿ࡜ࡇࢁࡣࠋ㸦ኴ⏣㸧 ࠺ࡕࡣ㈨㔠ຊࡣ࡞࠸࡛ࡍࡀࠋ
㸦ᒣᮏ㸧 ࡸࡣࡾእᅜேᩍဨࡣㄒᏛࡢே࡞࡝ࡀከ࠸ࡢ࡛ࡣ࡞࠸࡛ࡍ࠿ࠋ㸦ኴ⏣㸧 ㄒᏛࡢඛ⏕ࡶ࠸ࡽࡗࡋࡷ࠸ࡲࡍࡀࠊ
⮬↛⛉Ꮫࡸ♫఍⛉Ꮫࡢ᪉ࡶ࠸ࡽࡗࡋࡷ࠸ࡲࡍࠋ
㸦㛗㇂㸧 ಶேⓗ࡞ᚅ㐝ࡣู࡟ࡋ࡚ࠊ◊✲⎔ቃ࡜ࡋ࡚ࡣᇶ⏕◊ࡔࡗࡓࡽ⤯ᑐ࡟༑ศᘬࡁࡘࡅ
ࡿຊࡣ࠶ࡿ࡜ᛮ࠸ࡲࡍࡋࠊእᅜே◊✲⪅ࡀ୍ேࡱࡘࢇ࡜◊✲ࡍࡿࢃࡅ࡛ࡣ࡞ࡃ࡚ࠊ࿘ࡾ࡜ࡢ
ᇉ᰿ࢆపࡃࡍࢀࡤ኱Ⓨᒎࡍࡿ࣏ࢸࣥࢩࣕࣝࡀ࠶ࡿࡼ࠺࡟࠾ぢཷࡅ࠸ࡓࡋࡲࡍࠋ
㸦Ⲩᮌ㸧 ࡸࡣࡾᐙ᪘ࡀఫࡳࡸࡍ࠸⎔ቃࡣ㔜せ࡛ࡍࠋᒸᓮࡣࡲࡔྡྂᒇ࡟㏆࠸࠿ࡽ࠸࠸࡜ᛮ
࠸ࡲࡍࡀࠊ୕ᓥ࡞࡝ࡣ⤖ᵓ㞴ࡋ࠸ࡢ࡛ࡍࠊ
୧᪉ࡢ᪉ࡀࡁࡕࢇ࡜⫋ࢆぢࡘࡅࡽࢀࡿ࡜࠸࠺Ⅼ࡛ࠋࡇࡇࡣྡྂᒇ࡜ࡢ㊥㞳ࡀ๭࡜㏆ࡃ࡚ࠊ࠺ࡲࡃࡸࢀࡤ࡛ࡁࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮ࠸ࡲࡍࡀࠋ㸦すᮧ㸧 ࠿࡞ࡾࢺ࣮ࢱ࡛ࣝ࠸ࢁ࠸ࢁ㠃ಽࢆぢ࡞࠸࡜ࠊ࡞࠿࡞࠿බເࡋࡓࡔࡅ࡛ࡣ࠸࠸ேࡣ
᮶࡞࠸࡜࠸࠺≧ἣ࡛ࡍࡡࠋ
㸦ኴ⏣㸧 ୍ᮏ㔮ࡾ࠿ఱ࠿࡛⪃࠼࡚࠾࠿࡞࠸࡜ࠋ
㸦᳃㸧 ࡛ࡶࠊ❧ᆅ࡜ࡋ࡚ࡣ࠸࠸ࡢ࡛ࡣ࡞࠸࡛ࡍ࠿ࠋྡྂᒇࡔ࡜ࢫࢱࣥࢲ࣮ࢻ࡜࠸࠺࠿ࠊ࠸
ࢁ࠸ࢁ࡞ࡶࡢࡢ≀౯ࡀ㧗࠸ࡢ࡛ࡍࠋᒸᓮࡣࡕࡻࡗ࡜㞳ࢀ࡚࠸࡚ࠊ࠶ࡿព࿡࡛ࡣ⤯ጁ࡞ࣟࢣ࣮
ࢩ࡛ࣙࣥࡣ࡞࠸࡛ࡍ࠿ࠋ౛࠼ࡤࠊ࢔࣓ࣜ࢝ࡢヰࡤ࠿ࡾ࡛ᜍ⦰࡛ࡍࡀࠊ࢔࣓ࣜ࢝ࡣࢽ࣮࣮ࣗࣚ
ࢡ࡞࡝௨እࡣࡳࢇ࡞⏣⯋࡞ࡢ࡛ࡍࠋࡑ࠺࠸࠺ឤࡌ࡜ࡇࡇࡣఝ࡚࠸ࡿ࡜࠸࠺࠿ࠊ࡜࡚ࡶ࠸࠸ࡼ
࠺࡞Ẽࡀࡋࡲࡍࠋ ኱Ꮫ࡛ࡇࢀࢆࡸࡿ࡜࡞ࡿ࡜ࡍࡈࡃ኱ኚ࡞ࡢ࡛ࡍࡀࠊࡑ࠺࠸࠺ព࿡࡛ࡣ࣮࣋ࢩࢵࢡࢧ࢖࢚ࣥ
ࢫ࡜࠸࠺࠿ࠊ࣮࣋ࢩࢵࢡࣂ࢖࢜ࣟࢪ࣮ࡢ࣓ࢵ࡛࢝࠶ࡿᇶ⏕◊࡛ࡸࡗ࡚࠸ࡓࡔࡃ࡜࠸࠺ࡢࡣࠊ
ൗ㉺࡛ࡍࡀࠊ࠶ࡿព࿡࡛⚾ࡓࡕࡼࡾࡣࡍࡈࡃࣇࢵࢺ࣮࣡ࢡࡀ㍍࠸࡜࠸࠺࠿ࠋ࡛ࡍ࠿ࡽࠊࡇ࠺
࠸࠺࡜ࡇࢁ࡛ࡣࢻࣛࢫࢸ࢕ࢵࢡ࡞ᨵ㠉ࡣࡸࡾࡸࡍ࠸࡜ᛮ࠺ࡢ࡛ࡍࡡࠋ㸦すᮧ㸧 ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋ ࢔ࣥࢣ࣮ࢺ࡛ࡢࡈពぢࡢ୰࡛ࠊ୍ࡘࡣ࣎ࢺ࣒࢔ࢵࣉᆺࡢඹྠ฼⏝࡜࠸࠺ᅜ㝿㐃ᦠࢆጞࡵࡼ
࠺࡜ࡋ࡚࠸ࡿࡢ࡛ࡍࡀࠊࡇࢀ࡟ᑐࡋ࡚ࠊ㠀ᖖ࡟࠸࠸᪉ྥࡔ࡜ゝࢃࢀ࡚࠸ࡿࡢ࡛ࡍࠋࡑ࠺࠸࠺ពぢࡀฟ࡚ࡁ࡚࠾ࡾࡲࡍࡀࠊྜྷ⏣ࡉࢇࡢ᪉࠿ࡽࡑࡇࡢ࡜ࡇࢁࢆពぢ㸰ࡸពぢ㸱࡜࠿ࡽࡵ࡚ㄝ
᫂࠸ࡓࡔࡅࡲࡍ࠿ࠋ

− 78 −

㸦ྜྷ⏣㸧 ඛ࡯࡝࠾ヰࡋࡋࡓࡇ࡜ࡢ⧞ࡾ㏉ࡋ࡟࡞ࡿ࡜ࡇࢁࡣࡈᐜ㉧ࡃࡔࡉ࠸ࠋ
ࠕእ㒊Ⅼ᳨ホ౯࢔ࣥࢣ࣮ࢺࠖ㈨ᩱ㸳ࡢ 3 ࢆࡈぴୗࡉ࠸ࠋ࣎ࢺ࣒࢔ࢵࣉᆺࡣࠊඛ࡯࡝࠾ヰࡋࡋࡓࡼ࠺࡞ࢥࣥ
ࢭࣉࢺ࡛ࢃࢀࢃࢀ᳨࡛ウࡋ࡚㉮ࡽࡏࡼ࠺࡜ࡋ࡚࠸ࡿ࡜ࡇࢁ࡞ࡢ࡛ࡍࡀࠊពぢ㸰ࠊពぢ㸱ࡢඛ⏕࡟ពぢࢆ㡬࠸࡚࠸࡚ࠊ࡝ࡕࡽࡶホ౯ࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋ ពぢ㸰ࡢඛ⏕ࡣࠊ㐃ᦠࡣᮏ᮶ࢺࢵࣉࢲ࡛࢘ࣥࡣ࡞ࡃࠊ࣎ࢺ࣒࢔ࢵࣉᆺ࡛࡞࠸࡜ᐇ㉁ⓗ࡛࡞࠸࡜⚾ࡶᛮ࠸ࡲࡍࡢ࡛ࠊ✚ᴟⓗ࡞ᨭ᥼ࡀ࠶ࡿࡇ࡜ࡣ⚽㐓࡜⪃࠼ࡲࡍ࡜ゝࡗ࡚࠸ࡓࡔ࠸࡚ࠊࡑ
࠺ゝࡗ࡚࠸ࡓࡔࡅࡿ࡜࠺ࢀࡋ࠸ࡢ࡛ࡍࡀࠊពぢ㸱ࡢඛ⏕ࡶホ౯ࡋ࡚࠸ࡓࡔ࠸࡚࠸ࡲࡍࡀࠊ⤖ᒁࠊࡑࢀࢆᡤෆࡢάᛶ໬࡟ࡘ࡞ࡆ࡚ࠊ௒ᚋ࡝࠺ᒎ㛤ࡋ࡚࠸ࡃ࠿࡜࠸࠺࡜ࡇࢁࡀ㔜せࡔ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊ௒ᚋᐇ㉁ⓗ࡟࠺ࡲࡃ㉮ࡽࡏ࡚࠸ࡅࡿࡼ࠺࡟࡛ࡁࢀࡤ࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡜࠸࠺ࡇ࡜࡛ࠊᐇ㝿࡟ເ㞟ࡋ࡚㸳௳ࡀ᥇ᢥࡉࢀࠊ௒ᖺᗘ࠿ࡽ㛤ጞࡍࡿ࡜࠸࠺ᙧ࡟
࡞ࡾࡲࡍࠋ ࡑࢀ࡛ࡣࠊ㸲␒┠ࡢ㡯┠ࡢ᪂㡿ᇦࡢ㛤ᣅ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚࡜࠸࠺ࡇ࡜࡛ࠊ஭ཱྀඛ⏕ࡢ᪉࠿ࡽㄝ᫂ࢆ࠾㢪࠸ࡋࡲࡍࠋϫ ᪂㡿ᇦࡢ㛤ᣅ㸦஭ཱྀ㸧 ㈨ᩱ㸯ࡢ 3 ࡜㈨ᩱ㸱ࡢ 3 ࢆࡈぴୗࡉ࠸ࠋ᪂㡿ᇦࡢ㛤ᣅ࡜࠸࠺࡜ࡇࢁ࡛ࡣ
㸲Ⅼ࠶ࡾࡲࡋ࡚ࠊ᭱ึࡣ⎔ቃ㐺ᛂᡓ␎࡜᭩࠸࡚࠶ࡾࡲࡍࡀࠊࡇࢀࡣ㈨ᩱ㸱ࡢ 3 ࡟࠶ࡿࠕࣔ
ࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖࡀᖹᡂ  ᖺᗘࡢ≉ู⤒㈝࡛᥇ᢥࡉࢀ࡚ጞࡲࡗ࡚࠾ࡾࡲࡍࠋࡇࡢ୰㌟࡜ࡋ࡚ࡣࠊື≀ࠊ᳜≀ࡢ⏕యእ⎔ቃ࠿ࡽࡢᙳ㡪࡟࡝࠺཯ᛂࡍࡿ࠿࡜࠸࠺ࡇ࡜࡜ࠊ⏕యෆࡢ⎔ቃ࡟ᑐࡋ࡚࡝ࡢࡼ࠺࡟཯ᛂࡍࡿ࠿࡜࠸࠺࣓࢝ࢽࢬ
࣒ࢆࡁࡕࢇ࡜♧ࡋ࡚᫂ࡽ࠿࡟ࡋࡓ࠸࡜࠸࠺◊✲ࡀ⾜ࢃࢀ࡚࠸ࡲࡍࠋࡇࢀ࡟㛵㐃ࡋ࡚ࠊྡྂᒇ
኱Ꮫ࠿ࡽྜྷᮧඛ⏕࡟ᐈဨᩍᤵ࡜ࡋ࡚Ꮨ⠇⏕≀Ꮫ◊✲㒊㛛㸦⎔ቃ⏕≀Ꮫ㡿ᇦ㸧ࢆᢸᙜࡋ࡚࠸ࡓ
ࡔࡁࠊ◊✲ࢆᙉ໬ࡋ࡚࠸ࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ࡛ࡍࠋඛ࡯࡝࠿ࡽගᏛゎᯒᐊࡸࠊDSLM ࡸ IR-LEGO ࡞࡝ࠊ᪂ࡋ࠸㢧ᚤ㙾ࡢヰࡀฟ࡚ࡁࡲࡋࡓࡅࢀ࡝ࡶࠊගᏛゎᯒᐊࡢட஭≉௵෸ᩍᤵ࡜᫬✵㛫ไᚚ◊✲ᐊࡢ㔝୰෸ᩍᤵࡢ㸰ேࡀ୰ᚰ࡟࡞ࡗ࡚࠾ࡾࡲࡍࠋ㢧ᚤ㙾࡟㛵ࡋ࡚ࡣ㈨ᩱ㸱ࡢ 3 ࡟ DSLMࡢᑟධ࡜ᨵⰋ࡜࠸࠺ࡇ࡜࡛⡆༢࡟ฟ࡚࠸ࡲࡍࡀࠊࡉࡽ࡟῝ࡃ୰ࡶぢࡿ࡜࠸࠺ࡇ࡜࡛ࠊ㸰ගᏊ㢧ᚤ㙾ࢆ⤌ࡳྜࢃࡏࡓ᪂ࡓ࡞ࡶࡢࡀసࡽࢀ࡚࠸ࡲࡍࠋDSLM ࡢ᪉ࡣ㸷௳ࡢඹྠ◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍࠋIR-LEGO ࡢ᪉ࡣ  ௳࡟ୖࡿ◊✲ࢆࡋ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ 㢧ᚤ㙾࡟㛵ࡋ࡚ࡣኳᩥᏛࡢ᪉࡛౑ࢃࢀࡿ⿵ൾගᏛ⣔ࢆ㢧ᚤ㙾ࡢ࢖࣓࣮ࢪࣥࢢ࡟ᛂ⏝ࡋ࡚ࠊ⣽⬊ࡢ୰ࡢᾮࡢὶࢀ࡞࡝ࡀ࠶ࡗ࡚ᚤᑠჾᐁࡀࡼࡃぢ࠼࡞࠸࡜ࡇࢁࢆ⿵ൾࡋ࡚࠺ࡲࡃ᧜ࡿ࡜࠸
࠺ࡼ࠺࡞ࡇ࡜ࢆศ㔝㛫㐃ᦠㄢ㢟࡜࠸࠺ࡇ࡜࡛⋢⏣ຓᩍࡀ㐍ࡵ࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊࡇࢀࡶ⮬↛⛉Ꮫ◊✲ᶵᵓࡢ᪉࡛ࡍࡀࠊ᪂ศ㔝๰ᡂࢭࣥࢱ࣮࢖࣓࣮ࢪࣥࢢࢧ࢖࢚

− 79 −

ࣥࢫ◊✲ศ㔝࡜࠸࠺ࡇ࡜࡛ࠊᮌ᳃≉௵ຓᩍ࡜ຍ⸨≉௵ຓᩍࡢ࠾஧ேࡀ࢖࣓࣮ࢪࣥࢢ࡛ᚓࡽࢀ
ࡓࢹ࣮ࢱࢆ࡝ࡢࡼ࠺࡟ᐃ㔞໬ࡍࡿ࠿ࠊࡲࡓ᪂ࡓ࡞ゎᯒᡭἲࢆ㛤Ⓨࡍࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜࡛ࠊ
ࡇࡕࡽ࡟᮶࡚◊✲ᐊࢆᣢࡗ࡚࠸ࡲࡍࠋ
 ࢖࣓࣮ࢪࣥࢢࡣ࠸ࢁ࠸ࢁ࡞኱Ꮫ࡛ጞࡲࡗ࡚࠸ࡲࡍࡅࢀ࡝ࡶࠊ඲ᅜࡢ኱Ꮫ࡛⾜ࡗ࡚࠸ࡿࣂ࢖
࢜࢖࣓࣮ࢪࣥࢢࢆ㐃ᦠࡉࡏࡼ࠺࡜࠸࠺ࡇ࡜࡛ࠊᇶ⏕◊ࡀ㡢㢌ࢆྲྀࡗ࡚ࢪࣙ࢖ࣥࢺࢩ࣏ࣥࢪ࢘
࣒ࢆ⾜࠸ࡲࡋࡓࠋ
 ࡑࢀ࠿ࡽࠊ⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦OBC㸧࡛ࡍࠋඛ࡯࡝࠿ࡽఱᅇࡶฟ࡚ࡁࡲࡋࡓ
ࡅࢀ࡝ࡶࠊࡇࢀ࡟㛵ࡋ࡚ࡣ  ᖺ࠿ࡽࠊ᪂ࡓ࡞◊✲ศ㔝ࢆ๰ᡂࡍࡿ࡜࠸࠺ࡇ࡜࡛ጞࡲࡗ࡚࠸
ࡓࡢ࡛ࡍࡀࠊ᭱㏆ࡣᡤෆࡢඛ⏕ࡀ㠀ᖖ࡟ᛁࡋࡃ࡞ࡗ࡚ࠊᑡࡋࡇࡇࡀᡭⷧ࡟࡞ࡗ࡚࠸ࡲࡍࠋᡤ
ෆ࡜ࡋ࡚ࡣࡇࡢ OBC ࡣ࠶ࡿ⛬ᗘእᅜ࠿ࡽ࠸ࢁ࠸ࢁ࡞ேࢆ࿧ࡤ࡞ࡅࢀࡤ࠸ࡅ࡞࠸ࡋࠊ࠿࡞ࡾ
ᮏẼ࡛ࡸࡽ࡞࠸࡜㐍ࡲ࡞࠸࡜࠸࠺ࡇ࡜࡜ࠊ௦⾲⪅ࡣᇶ⏕◊௨እࡢ᪉ࡀ௒ࡲ࡛୰ᚰ࡟࡞ࡗ࡚࠸
ࡽࡗࡋࡷ࠸ࡲࡍࡢ࡛ࠊᇶ⏕◊ࡀ୺ᑟࡋ࡚࡝ࢇ࡜ࡸࡗ࡚࠸ࡿࢃࡅ࡛ࡣ࡞࠿ࡗࡓࢃࡅ࡛ࡍࠋࡑࡢ
ࡼ࠺࡞ࡇ࡜ࡀ࠶ࡗ࡚ᑡࡋఇࢇ࡛࠾ࡾࡲࡋࡓࠋ࢔ࣥࢣ࣮ࢺᅇ⟅㸦㈨ᩱ㸳㸧ࡢ 3 ࡢࡈពぢ㸰ࡢ୰࡟ࠕᐃ౛ⓗ࡟ࡸࡽ࡞ࡃ࡚ࡶࠊẼ㐠ࡀ⇍ࡋࡓ࡜ࡁ࡟ࡸࡗࡓࡽ࠸࠸ࡢ࡛ࡣ࡞࠸࠿ࠖ࡜࠸࠺ࡈព
ぢࢆ㡬ࡁࡲࡋ࡚ࠊࡲࡉ࡟ࡇ࠺࠸࠺ࡩ࠺࡟㐍ࡵࡓࡽ࠸࠸ࡢ࡛ࡣ࡞࠸࠿࡜ᇶ⏕◊࡛ࡶ⪃࠼࡚࠾ࡾࡲࡋࡓࠋࡓࡔࠊࡈពぢ㸯ࡢࡼ࠺࡟ࠕࡶ࠺ᑡࡋᨻᗓࡢ᪉࠿ࡽண⟬ᥐ⨨ࢆࡕࡷࢇ࡜ྲྀࡗ࡚ࠊࡁࡕ
ࢇ࡜ࡸࡗࡓ᪉ࡀ࠸࠸ࠖ࡜࠸࠺ࡈពぢࡶࡈࡊ࠸ࡲࡍࡢ࡛ࠊࡲࡓᚋ࡛ࡈពぢࢆ㡬ࡅࢀࡤ࡜ᛮ࠸ࡲࡍࠋ NIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡟ࡘ࠸࡚ࡣඛ࡯࡝࠿ࡽㄝ᫂ࡀ࠶ࡾࡲࡋࡓࡅࢀ࡝ࡶࠊࡇࡕࡽࡣ๭ྜࢸ
࣮࣐ࡀ☜❧ࡋ࡚࠸ࡿࡶࡢ࡛ࡍࠋOBC ࡢ᪉ࡣࡇࢀ࠿ࡽⴌⱆⓗ࡟ఱࢆࡸࡗ࡚࠸ࡃ࠿࡜࠸࠺ࡇ࡜࡞
ࡢ࡛ࡍࡀࠊྲྀࡾ࠶࠼ࡎẼ㐠ࡀ⇍ࡋࡓ࡜ࡁ࡟ࡣ OBC ࢆࡸࡾࡲࡋࡻ࠺࡜࠸࠺ࡇ࡜࡛ࡍࠋ࡝ࡕࡽ
ࡶෆእࡢࢥ࣑ࣗࢽࢸ࢕࣮࡟㈉⊩ࡍࡿ࡜࠸࠺ࡇ࡜ࡣ┠ᣦࡋ࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊ᭱ᚋࡢ㸲␒┠࡟ࠕ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࠖࡀ࠶ࡆࡽࢀ࡚࠸ࡲࡍࠋᇶ⏕◊ࡣ௒ࡲ࡛ࡣࠊ㑇ఏᏊᨵኚࢆ⡆༢࡟࡛ࡁࡿ࠸ࢃࡺࡿࣔࢹࣝ⏕≀ࢆ୰ᚰ࡟ࡋ࡚◊✲ࡋ࡚ࡁࡲࡋࡓ
ࡅࢀ࡝ࡶࠊ௒ᚋࡣࡲࡔࣔࢹࣝ⏕≀࡟࡞ࡗ࡚࠸࡞࠸ࡶࡢࢆࣔࢹࣝ໬ࡋ࡚ࠊࡶ࠺ᑡࡋᗈ࠸ศ㔝࡛◊✲ࡀ࡛ࡁࡿࡼ࠺࡟ࡋࡓ࠸࡜࠸࠺ࡇ࡜࡛ࠊ᪂つࣔࢹࣝ⏕≀ࡢ㛤ᣅ࡟ࡶ᪂ࡓ࡟ຊࢆධࢀ࡚࠸ࡃ
ࡇ࡜࡟࡞ࡾࡲࡋࡓࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋࡑࢀ࡛ࡣࠊ᪂㡿ᇦ㛤ᣅ࡟㛵ࡋ࡚ࡢࡈ㉁ၥࠊࡈウㄽࢆ࠾㢪࠸ࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋ
㸦஭ཱྀ㸧 2%& ࡞࡝ࢆ࡝࠺ࡋࡓࡽ࠸࠸࠿࡜࠸࠺ࡼ࠺࡞ࡈពぢࡀ࠶ࡾࡲࡋࡓࡽࠊࡍࡄ࡟ࡣ࡛ࡁ
࡞࠸࠿ࡶࡋࢀࡲࡏࢇࡀࠊࡐࡦ㡬ࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋ
− 80 −

㸦Ⲩᮌ㸧 㠀ᖖ࡟ࢥࣥࢭࣉࢳࣗ࢔ࣝ࡞ၥ
㢟࡞ࡢ࡛ࡍࡀࠊ᪂ࡋ࠸㡿ᇦࢆ࡝࠺ࡸࡗ࡚
ぢฟࡋ࡚ࡃࡿ࠿࡜࠸࠺ࡢࡣࠊ௒ࡢ࠾ヰࢆ⪺࠸࡚࠸ࡿ࡜ࠊOBC ࡣᑡࡋ㐪࠺ࡢ࠿ࡶࡋ
ࢀࡲࡏࢇࡀࠊ๭࡜ᡤෆ୰ᚰ࡟⪃࠼࡚࠸ࡽࡗࡋࡷࡿ࡜ᛮ࠺ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ࠶ࡿព
࿡ࠊ୰࡟࠸ࡿ࠶ࡿ⛬ᗘᖺ㓄ࡢே࡜࠸࠺ࡢ
ࡣ㢌ࡀᅛࡃ࡞ࡗ࡚࠸ࡿࡢ࡛ࠊࡶࡗ࡜ࣇࣞ
ࢵࢩࣗ࡞࡜࠸࠺࠿ࠊⱝ࠸ேࡢ▱ᜨࡀぢฟࡏࡿࡼ࠺࡞ࡶࡢࡀ࡞࠸ࡢ࠿࡞࡜࠸࠺ࡇ࡜
࡛ࡍࠋ࠺ࡕࡢሙྜ࡛ࡋࡓࡽࠊࡇࢀࡶࡲࡓ
࠶ࡿព࿡࠸࠸ຍῶ࡞ࡢ࡛ࡍࡀࠊⱝ࠸ேࢆ
᥇ࡿ࡜ࡁ࡟᪂ࡋ࠸ศ㔝ࡢேࢆ๭࡜ඃඛࡋ࡚᥇ࡗࡓࡾࡋ࡚࠸ࡿࡢ࡛ࡍࡡࠋࡑࢀࡣࢸࢽࣗ࢔ࢺࣛ
ࢵࢡࣞ࣋ࣝ࡞ࡢ࡛ࠊ࠶ࡿ⛬ᗘෑ㝤ࡀ࡛ࡁࡿ࡜࠸࠺ࡇ࡜ࡶ࠶ࡾࡲࡍࠋ㸦すᮧ㸧 ព㆑ⓗ࡟ࡑࡢࡼ࠺࡞ᙧ࡟ࡉࢀ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 ࡛ࡍ࠿ࡽࠊ᪂㡿ᇦ๰ᡂ࡜࠸࠸ࡲࡍ࠿ࠊࡑ࠺࠸࠺ࢱ࢖ࢺࣝ࡟ࡋ࡚࠸ࡿࡢ࡛ࠊ඲ࡃ᪂
ࡋ࠸ࡶࡢ࡜࠸࠺ࡇ࡜ࡣ࡞࠸࡛ࡍࡀࠊఱ࠿ኚࢃࡗࡓᙧࡢࡶࡢ࡛ࠊᑗ᮶ⓗ࡟ᡤෆ࡟ྲྀࡾ㎸ࡵࡿࡼ࠺࡞ࡶࡢࡀ࠶ࡿ࠿࡜࠸࠺ព㆑ࡣ࠶ࡿࡢ࡛ࡍࡡࠋࢸࢽࣗ࢔ࢺࣛࢵࢡ࡞ࡢ࡛ࠊ୰࠿ࡽ࠸ࡅࡤ࠶ࡿ
⛬ᗘෑ㝤ࡀ࡛ࡁࡿ࡜࠸࠺࡜ࡇࢁ࡞ࡢ࡛ࡍࠋ ࡇࡇ࡛௒ࠊⱝ࠸ᩍᤵࡢ᪉ࢆ᥇ࡗ࡚࠸ࡽࡗࡋࡷࡿࡢࡣࠊ
ࡸࡣࡾࣃ࣮࣐ࢿࣥࢺ࡛᥇ࡽࢀࡿ࠿ࡽࠊ
࡝ࡇࡲ࡛ෑ㝤ࡀ࡛ࡁࡿࡢ࠿ࡣࡕࡻࡗ࡜࡝࠺࡞ࡢ࠿࡜࠸࠺Ẽࡀࡍࡿࡢ࡛ࡍࡀࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ
㸦ྜྷ⏣㸧 Ⲩᮌඛ⏕࡟ఛ࠸ࡓ࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ᪂ࡋ࠸㡿ᇦ࡛᪂ࡋ࠸ࡇ࡜ࢆࡸࡗ࡚࠸ࡿேࢆ
ே஦࡜ࡋ࡚᥇ࡿ࡜࠸࠺ࡢࡣ୍␒኱ࡁ࡞ࡇ࡜ࡔ࡜ᛮ࠺ࡢ࡛ࡍࠋࡑࢀ࡟ຍ࠼࡚ࠊᐇ㝿࡟ࡑࡢ୰࡟
ධࡽࢀ࡚࠿ࡽࠊࡑࡢேࡢ◊✲ࢆ࠶ࡿព࿡౑ࡗ࡚ࠊ౛࠼ࡤᴫ⟬せồࡢ᪉࡟ࡘ࡞ࡆ࡚࠸ࡃࠊ࠶ࡿ
࠸ࡣఱࡽ࠿ࡢᙧ࡛ࡑࡢேࡢ௙஦ࢆ኎ࡾ࡞ࡀࡽࠊ౑࠸࡞ࡀࡽ࡜࠸࠺ࡢࡣࡍࡈࡃࣔࢳ࣮࣋ࢩࣙࣥ
࡟ࡶ࡞ࡿ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊࡑ࠺࠸ࡗࡓࡇ࡜ࡣ⪃࠼࡚࠸ࡽࡗࡋࡷࡗࡓࡾࡋࡲࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ⱝ࠸ே࡟㛵ࡋ࡚ࡣࠊࡑࡇࡲ࡛⪃࠼࡚࠸࡞࠸࡛ࡍࠋ
㸦ྜྷ⏣㸧 ࡞ࡿ࡯࡝ࠋ࠸࠸◊✲ࢆ࡜࡟࠿ࡃࡸࡗ࡚࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ࠸࠸◊✲࡜࠸࠺࠿ࠊ࠶ࡿ⛬ᗘࣜࢫࢡࢆྲྀࡗ࡚ࡸࡿࡼ࠺࡞ࡇ࡜ࢆዡບࡋࡼ࠺࡜ࡋ࡚

− 81 −

࠸ࡿࡢ࡛ࠊࡑࢀࢆ༶ࠊᴫ⟬せồ࡜࠿࠸࠺ࡇ࡜࡟㛵ࡋ࡚ࡣࡕࡻࡗ࡜↓㈐௵ࡔ࡜ᛮ࠺ࡢ࡛ࡍࡡࠋ
ࡑࢀ௨እ࡟ࡣಶࠎேࡀ᪂ࡋ࠸ࡶࡢ࡜࠸࠺ࡢࡣ࠶ࡿࡢ࡛ࡍࠋ㏫࡟ゝ࠺࡜ࠊࡇࢀࡣ㠀ᖖ࡟↓㈐௵
࡞ヰ࡛ࠊⱝ࠸ேࢆࡱࢇ࡜᥇ࡗ࡚ࡁ࡚ࠕఱ࠿᪂ࡋ࠸ࡇ࡜ࡸࢀࠖ࡜ゝࡗ࡚࠸ࡿࡢ࡛ࠊ㏫࡟ᡤෆ࡛
ࡶࡁࡕࢇ࡜⪃࠼ࡿ࡜࠸࠺ࡇ࡜ࡶ㔜せࡔ࡜ᛮ࠺ࡢ࡛ࡍࠋ
㸦ኴ⏣㸧 ࡛ࡶࠊࡑࡢⱝ࠸ேࡀ㸯ே࡛ࢫࢱࣥࢻ࢔࣮࡛ࣟࣥධࡗ࡚ࡁࡓࡽࠊࡑࡢศ㔝ࢆసࡾୖࡆࡿ࡜࠸࠺ࡢࡣ࡞࠿࡞࠿㞴ࡋ࠸ࡢ࡛ࡣ࡞࠸࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ஧㠃ᛶࡀ࠶ࡿ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ୍ࡘࡣⱝ࠸ேࡀ᮶࡚ࠊ࣏ࢫࢻࢡ࡜ࢸࢡࢽࢩࣕࣥ➼ࢆ௜ࡅ࡚ࠊ࠶ࡿ⛬ᗘ᭱ึࡣ࢚ࢫࢱࣈࣜࢵࢩࣗ࡟࠾㔠ࢆ௜ࡅࡿ࡜࠸࠺ࠊ࢔࣓ࣜ࢝࡜ࢥࣥ࣌ࢸ࢕
ࢸ࢕ࣈ࡞㔠㢠ࢆ⏝ពࡍࡿ࡜࠸࠺ࡢࡀ᭱ึࡢࡸࡾ᪉࡛ࠊࡑࢀ࡛࠶ࡿ⛬ᗘࡸࡾࡲࡍࠋࡇࢀࡣ࣏ࢪ
ࢸ࢕ࣈ࡞㠃࡛ࡍࠋࢿ࢞ࢸ࢕ࣈ࡞㠃࡛ࡣኴ⏣ඛ⏕ࡀ࠾ࡗࡋࡷࡗࡓࡢࡣࡲࡉ࡟ࡑࡢ࡜࠾ࡾ࡛ࠊᮏ
ᙜࡣศ㔝ࢆ୰࡛࠶ࡿ⛬ᗘỴࡵ࡚ࠊ」ᩘ㞠࠼ࡓࡽ୍␒࠸࠸࡛ࡍࡡࠋࡑࢀࡣṧᛕ࡞ࡀࡽ࠺ࡕ࡛ࡣ
࡛ࡁ࡚࠸࡞࠸࡛ࡍࠋఱࢆ㑅ࢇࡔࡽ࠸࠸࠿ࡀศ࠿ࡽ࡞࠸ࡢ࡛ࡍࡡࠋ
㸦ኴ⏣㸧 ࡑ࠺࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡑࢀࡀ࠶ࡿ⛬ᗘఙࡧࡿ࡜ᛮࡗࡓࡽࠊࡑࢀࢆࢸࢽࣗ࢔࡛ᩍᤵ࡟ࡍࡿ࡜࠿ࠊࡑ࠺࠸࠺
ࡇ࡜࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ࠼࠼ࠊࡑࢀࡣࢸࢽࣗ࢔ࢺࣛࢵࢡ࡛ࡍ࠿ࡽࠋࡓࡔࠊࢫࢱࣥࢲ࣮ࢻࡢྲྀࡾ᪉ࡀࠊ༢࡟
࢔ࢳ࣮ࣈ࣓ࣥࢺࡔࡅࢆぢ࡚࠸ࡿࢃࡅ࡛ࡣ࡞ࡃࠊࣜࢫࢡࢆྲྀࡾ࡞ࡀࡽ᪂ࡋ࠸ࡇ࡜ࢆࡸࡗ࡚࠸ࡃ
ே࡛ࠊࡑࡇ࡛ࡢఙࡧࢆぢ࡚࠸ࡿࡢ࡛ࠊࡕࡻࡗ࡜㐪࠺࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ḟࡢࢫࢸࢵࣉ࡟࡞ࡗࡓࡽࠊࡑࡢ᪉ࡀ⾜ࡁࡑ࠺ࡔࡗࡓࡽࠊࡑࡢ᪉ࢆᩍᤵ࡟ୖࡆࡿ࡜
࠿ࠊࡑ࠺࠸࠺ࡇ࡜࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ୖࡆ࡚ࠊࡑࢀࡀ௒ᗘࡣḟࡢඛ౛࡟ࡶ࡞ࡾࡲࡍࡋࠋ
㸦ྜྷ⏣㸧 ࡑࡢࢫࢱࣥࢻ࢔࣮࡛ࣟࣥ࡜࠾ࡗࡋࡷࡗࡓ࡜ࡇࢁࡣࠊࡶࡋ࠿ࡋࡓࡽ࣓ࣥࢱ࣮ࡢヰ࡜ࡶ┤⤖ࡍࡿヰࡔ࡜ᛮ࠺ࡢ࡛ࡍࡀࠋ
㸦Ⲩᮌ㸧 ከศ࣓ࣥࢱ࣮ࡔࡅ࡛ࡣ࡞࠸࡜ᛮ࠺ࡢ࡛ࡍࠋ࣓ࣥࢱ࣮ࡣࡶࡕࢁࢇ௜ࡅ࡚࠸ࡲࡍࠋ
㸦ྜྷ⏣㸧 ࡞ࡿ࡯࡝ࠋ
㸦Ⲩᮌ㸧 ࣓ࣥࢱ࣮ࡣࡶࡕࢁࢇ௜ࡅ࡚ࡸࡗ࡚࠸ࡲࡍࡀࠊኴ⏣ඛ⏕ࡀ࠾ࡗࡋࡷࡗࡓࡢࡣࠊ౛࠼
ࡤྠࡌࡼ࠺࡞ศ㔝ࡢேࡀ㸱ே࠸ࡿ࡜඲↛㐪࠺ࡢ࡛ࡍࡡࠋ

− 82 −

㸦ኴ⏣㸧 ඲↛㐪࠺ࡢ࡛ࡍࠋ࠺ࡕࡢ࡜ࡇࢁ
࡛」㞧⣔⏕≀ࢆࡸࡗ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊ
ࡑࢀࡣᮾி኱Ꮫࡀ᫬㝈ⓗ࡞㸳ᖺࡄࡽ࠸ࡢ◊✲ࢭࣥࢱ࣮ࡳࡓ࠸࡞ࡢࢆసࡗ࡚ࡃࢀ࡚ࠊᩍ
ᤵ㸯ྡ࡛ࠊ≉௵෸ᩍᤵఱྡ࡜࠸࠺ᙧ࡛᥇⏝࡛ࡁࡿᙧ࡛࢟ࢵࢡ࢜ࣇࡋ࡚࠸ࡿࡢ࡛ࡍࡡࠋ
ࡑࢀ࡟ࣃ࣮࣐ࢿࣥࢺࡢேࡀఱே࠿ຍࢃࡗ࡚
࠿࡞ࡾࡢࢢ࣮ࣝࣉ࡟࡞ࡗ࡚࠸࡚ࠊࡑࡇ࡟౛
࠼ࡤ⏕࿨ືែࣉࣟࢢ࣒ࣛ࡞࡝࡛ᨻᗓࡢண⟬ࡀ௜࠸࡚ࡁࡓࡾࠊ⌮Ꮫ㒊ࡢ≀⌮࡜⤌ࢇ࡛ᴫ⟬せồࢆฟࡋࡓࡾ࡜࠸࠺ືࡁ࡟࡞ࡗ࡚ࡁ࡚ࠊ
᪂ࡋ࠸ศ㔝ࢆసࢁ࠺࡜࠸࠺ὶࢀࡀฟ࡚ࡁ࡚࠸ࡲࡍࠋ㸦ྜྷ⏣㸧 ࡑ࠺ࡍࡿ࡜ࠊⱝ࠸ேࡶࡑࡇ࡟ධࡗ࡚ࡃࡿࡔࢁ࠺ࡅࢀ࡝ࡶࠊ࠶ࡿព࿡ࠊࡑࡢ๓࡟ᯟ
ࡀ࠶ࡗ࡚ࠋ
㸦ኴ⏣㸧 ࡑ࠺࡛ࡍࡡࠋ௙⤌ࡳࢆ࠶ࡿ⛬ᗘసࡗ࡚࠾࠿࡞࠸࡜ࠊࡑࡢὶࢀࡀ࡛ࡁ࡚ࡇ࡞࠸࡜࠸
࠺࡜ࡇࢁࡀ࠶ࡾࡲࡍࠋ
㸦᳃㸧 ⚾ࡶྠࡌពぢ࡜࠸࠺࠿ࠊࢥࣥࢭࣉࢳࣗ࢔ࣝ࡟ఱࢆ᪂ࡋ࠸ศ㔝࠿࡜࠸࠺ࡢࡣࠊᗄࡽ᪂
ࡋࡃ࡚ࡶࠊࡑࡢே஦ࢆࡉࢀࡿᩍᤵࡢ᪉ࠎࡀ࡝࠺࠸࠺◊✲ࢆ௒ࡉࢀ࡚࠸࡚ࠊ௒ᚋࠊ࠸࠸ព࿡࡛
ࡢࣂ࢖࢜ࣟࢪ࣮ࡢࢺࣞࣥࢻࡀ࡝࠺⾜ࡃ࠿࡜࠸࠺࠶ࡿ✀ࡢࣅࢪࣙࣥࢆⓙࡉࢇᜍࡽࡃᣢࡗ࡚࠸ࡽ
ࡗࡋࡷࡗ࡚ࠊࡑ࠺࠸࠺᪉ࡓࡕࡀ᪂ࡋ࠸࡜ㄆࡵࡿࢃࡅ࡛ࡍ࠿ࡽࠊ㞳ࢀࡓࠊ඲↛ศ࠿ࡽ࡞࠸ࡶࡢ
ࡀ㑅ࡤࢀࡿࡇ࡜ࡣከศ࡞࠸ࡔࢁ࠺࡜⚾ࡣᛮࡗ࡚࠸ࡿࡢ࡛ࡍࡡࠋ
 ࡑ࠺࠸࠺ព࿡࡛࠶ࡿ࡜ࠊኴ⏣ඛ⏕ࡢ࠾ヰࢆ⪺࠸࡚࠸࡚ᛮࡗࡓࡢࡣࠊᡭ๓࿡ჯ࡛ࡍࡀࠊ⚾ࡣࢽ࣮ࣗࣟࢧ࢖࢚ࣥࢫ࡛࠸࡚ࠊ⚄⤒ࣂ࢖࢜ࢆࡸࡗ࡚࠸ࡲࡍࠋࡑࡋ࡚ୖᕝෆࡉࢇࡣࡓࡲࡓࡲዪᛶ
࡛ࡍࡀࠊ ṓ࡛ຓᩍ࠿ࡽࣃ࣮࣐ࢿࣥࢺࡢᩍᤵ࡟ࡋࡲࡋࡓࠋ㸯ᖺ๓࡟ㅮᖌ࡜ࡋ࡚ BSI ࠿ࡽᆏෆ༤Ꮚࡉࢇࡀ᮶ࡽࢀ࡚ࠊ୧᪉࡜ࡶ᝟ሗฎ⌮ࢆࡸࡗ࡚࠸࡚ࠊ
ࠕࡇࢀࡣ⤌ࡵࡿࡡࠖ࡜࠸࠺ࡇ࡜࡛ࠊᴫ
⟬せồ➼ࡢ㈨㔠ࢆ⏦ㄳࡋ࡚ࡶࡽࡗࡓࡾࠊ኱Ꮫࡢࢧ࣏࣮ࢺࢆᚓࡿྍ⬟ᛶࢆ᥈ࡗ࡚࠸ࡲࡍࠋ
 ࡛ࡶࠊ⚾ࡶࡓࡲࡓࡲዪᛶ࡛ࡍࡀࠊࡑ࠺࠸࠺᪉ࡓࡕࡀ࠸࡞ࡅࢀࡤࠊ᪂ࡋ࠸ࢥࣥࢭࣉࢳࣗ࢔ࣝ
࡞ࣃࣛࢲ࢖࣒ࢩࣇࢺࢆ㉳ࡇࡍࡼ࠺࡞ࡇ࡜ࡣᜍࡽࡃఱࡶ࡛ࡁ࡞࠿ࡗࡓࢃࡅ࡛ࡍࠋⱝ࠸᪉ࡀ᮶ࡽ
ࢀ࡚ࠊࡓࡲࡓࡲዪᛶ࡜࠸࠺ࡔࡅ࡞ࡢ࡛ࡍࡀࠊᴫ⟬ࡲ࡛⾜ࡗ࡚࠸ࡿࡢ࡛ࠊࡑ࠺࠸࠺ࡇ࡜ࡣ࠶ࡿ
࠿࡜ᛮ࠸ࡲࡍࠋࡲࡉ࡟࣎ࢺ࣒࢔ࢵࣉ࡛ࡸࡽࢀ࡚࠸ࡲࡍࡼࡡࠋ⚾ࡓࡕࡶࡲࡉ࡟࣎ࢺ࣒࢔ࢵࣉ࡛
ࡸࡗࡓࡢ࡛ࡍࠋ⏨ࡢඛ⏕ࡓࡕ࡟ࡣࠊࡣࡽࡣࡽࡋ࡚࠸ࡓ࡞࡝࡜ゝࢃࢀ࡚ࡋࡲࡗࡓࡢ࡛ࡍࡀࠊ඲
ࡃࢼࢳ࡛ࣗࣛࣝࠊ඲↛ࢫࢺࣞࢫࡀ࡞࠸ࡢ࡛ࡍࡡࠋ

− 83 −

㸦ྜྷ⏣㸧 ࡑ࠺ࡔ࡜ᛮ࠸ࡲࡍࠋ
㸦᳃㸧 ௒࠸ࡽࡗࡋࡷࡿࣉࣟࣇ࢙ࢵࢧ࣮ࡢ᪉ࡓࡕࡶࡳࢇ࡞ᕳࡁ㎸ࢇ࡛࠸ࡗ࡚࡜࠸࠺ᙧ࡟࡛ࡁ
࡚࠸ࡿࡢ࡛ࠊᡭ๓࿡ჯ࡞ࡢ࡛ࡍࡀࠊ⏨ዪ㛵ಀ࡞ࡃࠊࡇࢀࡣ࠶ࡾࡔ࡞࡜ᛮ࠸ࡲࡍࠋ
㸦ྜྷ⏣㸧 ࠸࠸᪉ࡀ᮶ࡽࢀ࡚ࠊࡑࡢ◊✲࡟┦஌ຠᯝࡀฟ࡚ࡁ࡚࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦᳃㸧 ࡛ࡶࠊ࠸࠸᪉ࢆࡲࡎ᥇ࡿ࡜࠸࠺ࡢࡀ኱஦࡛ࡍࠋ᥇ࡿ᪉ࡣࠊ௒࠸ࡽࡗࡋࡷࡿ᪉ࡀ᥇ࡿ
ࢃࡅ࡛ࡍࠋ
㸦ྜྷ⏣㸧 ࠶࠶ࠊ࡞ࡿ࡯࡝ࠋ
㸦᳃㸧 ศ࠿ࡾࡲࡍ㸽 ࡔ࠿ࡽࠊࠕ᪂ࡋ࠸ࠖ࡜࠸࠺ࡇ࡜ࠊఱࡀ᪂ࡋ࠸࠿࡜࠸࠺ࡇ࡜ࡢពᛮỴᐃࡣ௒࠸ࡿ᪉ࡓࡕࡀࡋ࡚࠸ࡿࢃࡅ࡛ࡍࡼࡡࠋࡔ࠿ࡽࠊᚲࡎࡑࢀࡣࣟࢪࢵࢡ࡜ࡋ࡚ࡘ࡞ࡀࡗ࡚࠸
ࡿࡣࡎ࡛ࠊࡑࡢ᪂ࡋ࠸࡜࠸࠺ࡇ࡜ࢆᛮ࠺࡜࠸࠺࠿ࠋศ࠿ࡾࡲࡍ࠿ࡡࠋ
㸦ྜྷ⏣㸧 ࡞ࡿ࡯࡝ࠋࡶࡋ࠿ࡋࡓࡽ㛫㐪ࡗ࡚࠸ࡿ࠿ࡶࡋࢀࡲࡏࢇࡀࠊึࡵ࡚⪺࠸ࡓወࢆ࡚ࡽ
ࡗࡓࡼ࠺࡞ヰࡀ᪂ࡋ࠸࡜࠸࠺ࢃࡅ࡛ࡣ࡞ࡃ࡚ࠋ
㸦᳃㸧 ࠕ᪂ࡋ࠸ࠖ࡜࠸࠺ࡢࡀࠊ࠶ࡾࡲࡍࡼࡡࠋ
ࠕࡇࢀࡣ᪂ࡋ࠸ࠖ࡜࠸࠺ࣆࣥ࡜᮶ࡿ࡜࠸࠺ࡢ
ࡀࠋ࡛ࡶࠊே஦ࢆࡉࢀࡿ᪉ࡀఱ࠿ࡋࡽᣢࡗ࡚࠸ࡽࡗࡋࡷࡽ࡞࠸࡜ࠋ
ࠕఱࡇࢀࠊ⪺࠸ࡓࡇ࡜ࡶ࡞
࠸ࠖ࡜࠸࠺ேࢆ㞠⏝ࡍࡿ࠿ࠊࡑࡇࡲ࡛⾜ࡃ࠿࡜࠸࠺࡜ࠊࡑࢀࡣࡕࡻࡗ࡜࡞࠸ࡢ࡛ࡣ࡞࠸࠿࡜
⚾ࡣᛮ࠺ࡢ࡛ࡍࡀࠊ࡝࠺࡛ࡋࡻ࠺࠿ࠋ⤖ᒁࠊࡑࡢே஦ࢆࡉࢀࡿ᪉ࡀ᪂ࡋ࠸࡜ឤࡌࡿࡶࡢࢆ኱
஦࡟ࡉࢀࡓ᪉ࡀ⚾ࡣ࠸࠸࡜ᛮ࠸ࡲࡍࠋ⤖ᒁࠊḟࡢᴫ⟬࡟ࡶࡘ࡞ࡀࡗ࡚࠸ࡁࡲࡍࡼࡡࠋ᪂ࡋ࠸
ࢧ࢖࢚ࣥࢫ࡛࣡ࢡ࣡ࢡࡍࡿ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࡢ࡛ࠊ࠸࠸ព࿡࡛ࠊ⣧⢋࡞ព࿡࡛ࡳࢇ࡞ࡀ
◊✲ࢆࢧ࣏࣮ࢺࡋࡲࡍࡼࡡࠋ࡛ࡍ࠿ࡽࠊࡑ࠺࠸࠺ᙧࡢ᪉ࡀࡑࢀࡣࡑࢀ࡛࠸࠸ࡢ࡛ࡣ࡞࠸࠿࡜
ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋ᪂㡿ᇦࢆ㛤Ⓨࡍࡿࡓࡵ࡟ࡣேࡀࡸࡣࡾ኱஦࡛ࠊ◊✲ᡤࡢ୰࡛࡝࠺࠸࠺ࡶࡢࡀ᪂㡿ᇦ࡛࡜࠸࠺ࡇ࡜ࢆࢳ࢙ࢵࢡࡋ࡚ࠊࡁࡕࢇ࡜᪉ྥᛶࢆฟࡋ࡚࠸
ࡃࠋ௒ࡢヰࡔ࡜ࠊ࣓ࣥࢱ࣮ไᗘࡶࡦࡻࡗ࡜ࡋࡓࡽࡑࡇ࡟࠺ࡲࡃ฼⏝ࡋࡓࡽ࠸࠸ࡔࢁ࠺ࡋࠊࡑ
ࢀ࠿ࡽࠊࡇࡇࡢ◊✲ᡤ࡜ࡋ࡚ࡣᴫ⟬せồ࡛ᗄࡘ࠿ࠊ㏆࠸ᑗ᮶ࡢࡇ࡜࡛ࡍࡀࠊ௒࡛ࡣ౛࠼ࡤ᪂つࣔࢹࣝ⏕≀ࡢ㛤Ⓨࢭࣥࢱ࣮࡜࠸࠺᪋タࢆసࡗ࡚࠾ࡾࡲࡋ࡚ࠊ
ࡑࡇ࡟≉௵ࡢᩍᤵ࠿෸ᩍᤵ࠿ࠊ
ࡑࡢ㎶ࢆࡇࢀ࠿ࡽỴࡵ࡚ࠊᐇ㝿࡟㞠⏝ࡋ࡚ࡑࢀࢆ㉮ࡽࡏࡼ࠺࡜࠸࠺ᙧ࡛㐍ࡵ࡚࠾ࡾࡲࡍࡅࢀ
࡝ࡶࠊࡸࡣࡾேࡀ㠀ᖖ࡟㔜せࡔ࡜࠸࠺ࡈᣦ᦬ࡔ࡜ᛮ࠸ࡲࡍࠋ
㸦᳃㸧 ࡛ࡶࠊఱࡶ⪃࠼ࡀ࡞ࡃ࡚ࡶࠊ࠶ࡿேࡀఱ࠿ࢆⓎ⾲ࡋࡓ࡜ࡁ࡟ࠕ࠶ࡗࠊࡇࢀࡔࠖ࡜࠸
࠺ࡢࡶ࠶ࡾࡲࡍࡼࡡࠋࢺࢵࣉࢲ࡛࢘ࣥࡣ࡞ࡃ࡚ࡶࠊ
ࠕ࠶ࡗࠊࡇࢀࡣ᪂ࡋ࠸ࠖ࡜ࡑࡢ▐㛫࡟ᛮࡗ− 84 −

࡚ࡶ࠸࠸࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ࡛ࡶࠊఱࢆ᪂ࡋ࠸࡜ᛮ࠺࠿࡜࠸࠺ࡇ࡜ࡣࠊⓙࡉࢇࡀࡸࡗ࡚ࡇࡽࢀ
࡚࠸ࡿࢧ࢖࢚ࣥࢫ࡟⤯ᑐ࡟౫Ꮡࡋ࡚࠸ࡿ࡜⚾ࡣᛮ࠺ࡢ࡛ࠊࡑ࠺࠸࠺ព࿡࡛ࡣࠕ࠼ࡗࠊࡇࢀఱ
࡞ࡢ㸽ࠖ࡜ゝ࠺ேࢆ㞠⏝ࡋ࡞࠸࡜ᛮ࠺ࡢ࡛ࡍࡼࡡࠋࡸࡣࡾࡘ࡞ࡀࡗ࡚࠸ࡿ࡜࠸࠺࠿ࠋ㸦すᮧ㸧 ࡜࠸࠺ࡼ࠺࡞࡜ࡇࢁࢆཧ⪃࡟ࡉࡏ࡚࠸ࡓࡔ࠸࡚ࠊ௒ࡲ࡛ᇶ⏕◊ࡣ࣓ࣥࢱ࣮ไᗘࡀ
࡞࠿ࡗࡓࡢ࡛ࠊ㑇ఏ◊ࡢ౛ࡣ㠀ᖖ࡟ࡼࡃཧ⪃࡟࡞ࡾࡲࡍࠋ㑇ఏ◊࡛⾜ࡗ࡚࠾ࡽࢀࡿࢸࢽࣗ࢔
ࢺࣛࢵࢡไᗘ࡛ࡍࡀࠊ᪂㡿ᇦࡢ㛤Ⓨ࡟᭷ຠ࡞ࡢ࡛ࡣ࡞࠸࠿࡜࠸࠺ពぢࡀ࠶ࡾࡲࡍࡡࠋࢸࢽࣗ
࢔ࢺࣛࢵࢡไᗘࡣࠊᩥ⛉┬࡟ᛂເࡋ࡚ࠋ
㸦Ⲩᮌ㸧 ࠺ࡕࡣࡶ࡜ࡶ࡜ࡑࢀ௨๓࠿ࡽ⮬ศࡢ࡜ࡇࢁࡢ࠾㔠࡛ጞࡵ࡚ࠊࡑࢀ࠿ࡽ JST ࡢ࠾㔠ࢆྲྀࡗ࡚ࠊࡑࢀࡶࡑࢁࡑࢁษࢀࡿࡢ࡛ࡍࡡࠋࡲࡓ⮬ศࡢ࡜ࡇࢁ࡛ࡸࡽ࡞࠸࡜࠸ࡅ࡞࠸ࡢ࡛ࡍ
ࡀࠊ๭࡜࠾㔠ࢆฟࡋࡓࡾࡍࡿࡼ࠺࡟ࡋ࡚࠸ࡲࡍࡢ࡛ࠊ⥆ࡅ࡚࠸ࡃ࡜ࡁࡘ࠸ࡢ࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡑ࠺࡞ࡢ࡛ࡍࡡࠋࡑ࠺ࡍࡿ࡜ࠊJST ไᗘ࡟஌ࡗ࡚ࡸࡗ࡚࠸ࡿࢃࡅ࡛ࡣ࡞ࡃ࡚ࠊ⮬ศࡢ࡜ࡇࢁࡢ࠾㔠࡛ࠋ㸦Ⲩᮌ㸧 ᭱ึࡣ⮬ศࡢ࡜ࡇࢁࡢ࠾㔠࡛ࡸࡗ࡚ࠊJST ࡢ࠾㔠ࡀ࠶ࡿ࡜ࡁࡣࡑࢀࢆ౑࠺ࠋ௒ࡶࠊ
௒ᖺᗘ࠸ࡗࡥ࠸ࡄࡽ࠸࠶ࡿࡢ࡛ࡍࡀࠊࡑࢀࢆ౑ࡗ࡚࠸ࡲࡍࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍ࠿ࠋ
㸦Ⲩᮌ㸧 ࡑࢀ࡛ษࢀࡲࡍࡀࠊࡑࡢᚋࡶᑡࡋ᥇⏝ࡋ࡚࠸ࡲࡍࡢ࡛ࠊࡑ࠺ࡋࡓேࡓࡕ࡟ࡘ࠸࡚
ࡣᣢࡕฟࡋ࡛ࡍࡡࠋ㸦すᮧ㸧 ᣢࡕฟࡋ࡞ࡢ࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 ࡔ࠿ࡽࠊ୰ࡢࢥࣥࢭࣥࢧࢫࡀ࡞࠸࡜࡛ࡁ࡞࠸࡜ᛮ࠸ࡲࡍࠋ㸦すᮧ㸧 ศ࠿ࡾࡲࡋࡓࠋᇶ⏕◊࡛ࡑࡢᑟධࢆᑡࡋ㆟ㄽࡋࡓࡇ࡜ࡀ࠶ࡗࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊ
ࡸࡣࡾࡑ࠺ࡍࡿ࡜㈈ົⓗ࡟ࡶ⪃࠼࡚࠸࠿࡞࠸࡜࠸ࡅ࡞࠸࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦ኴ⏣㸧 ᶵᵓ඲య࡛⪃࠼ࡿࡇ࡜ࡣ࡛ࡁ࡞࠸ࡢ࡛ࡍ࠿ࠋ㸦すᮧ㸧 ௒ࡢẁ㝵࡛ࡣࠊࡑࢀࡒࢀࡢ◊✲ᡤࡈ࡜࡟࠾㔠ࡀ᮶࡚࠾ࡾࡲࡍࡢ࡛ࠋ
㸦᳃㸧 ⤫ྜࣂ࢖࢜࡞࡝ࡣ࡝࠺࡛ࡍ࠿ࠋࡑࡢ୕ࡘࢆ᮰ࡡࡿᙧ࡛࡝࠺࡞ࡢ࡛ࡋࡻ࠺࠿ࠋ㸦すᮧ㸧 ⤫ྜࣂ࢖࢜ࡣ࡝࠺࡛ࡋࡻ࠺ࠋᑠᯘඛ⏕ࠋ㸦ᑠᯘ㸧 ⤫ྜࣂ࢖࢜ࡣࠊ୕ࡘࡢ◊✲ᡤࡢ◊✲ࢆ࣮࣋ࢫ࡟ࡋ࡚⤫ྜⓗ࡞◊✲ࢆࡍࡿ࡜ࡇࢁ࡛ࡍࠋ㸦᳃㸧 ࡛ࡍࡼࡡࠋ

− 85 −

㸦ᑠᯘ㸧 ⤫ྜࣂ࢖࡛࢜ࡣࠊ⊂⮬ࡢᴫ⟬せồ࡜࡜ࡶ࡟  ◊✲ᡤࡢࢧ࣏࣮ࢺࡢࡶ࡜ࠊ≉௵෸ᩍᤵࢆ㞠⏝ࡋ࡚ࠊ᪂ࡋ࠸᪉ྥࡢ◊✲ࢆ㛤ጞࡋࡘࡘ࠶ࡾࡲࡍࠋ
㸦ᒣᮏ㸧 㑇ఏ◊ࡶྡྂᒇ኱Ꮫࡶࢸࢽࣗ࢔ࢺࣛࢵࢡไᗘ࡛෸ᩍᤵࡢ᪉ࢆ㞠⏝ࡉࢀ࡚ࠊ᭱⤊ⓗ࡟ఱே࠿ࢆᩍᤵ࡟ୖࡆ࡚࠾ࡽࢀࡿ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊࡑࡢᩍᤵࡢ࣏ࢫࢺࡀࡇࢀ࠿ࡽࡶࡁࡕࢇ࡜
☜ಖ࡛ࡁࡿ࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍ࠿ࠋ
㸦᳃㸧 ࠺ࡕࡢሙྜࡣᅇࡋ࡚࠸ࡲࡍࠋࢸࢽࣗ࢔ࢺࣛࢵࢡ࡛㸳ᖺᚋ࡟ᑂᰝ࡜࠸࠺࠿ࠊᩍᤵ࡛᥇
ࡽࢀ࡚ࠊ࡜࡟࠿ࡃࢸࢽࣗ࢔ࢺࣛࢵࢡࢆࡸࡿ࡜ࡁࡣࡶ࠺☜ಖࡋ࡚࠸࡚ࠊ㸳ᖺᚋ࡟ࡣ࠸ࢃࡺࡿṇつࡢ࣏ࢪࢩࣙࣥࡀ✵࠸࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡀ᮲௳࡛ࡸࡾࡲࡍࡡࠋᇶᮏⓗ࡟ࡣࡑ࠺࠸࠺ᙧ࡛ࡍࠋ
ࡔ࠿ࡽࠊ㸳ᖺᚋࢆぢᤣ࠼࡚ࠊேࡀࣜࢱ࢖࢔ࡉࢀ࡚࡝࠺ࡢࡇ࠺ࡢ࡜࠸࠺ࡇ࡜ࡀ࠶ࡿࡔࢁ࠺࡜࠸࠺ࡢࢆぢ㉺ࡋ࡚ࠊ୍ᛂᑂᰝࡣཝ᱁࡟ࡸࡾࡲࡍࡀࠊṧࡗࡓሙྜࡶࡕࡷࢇ࡜࣏ࢪࢩࣙࣥࡀ࠶ࡿ࡜
࠸࠺௬ᐃࢆసࡾࠊࡑࢀ࡛ເ㞟ࢆ࠿ࡅࡿ࡜࠸࠺ࠊ⤖ᵓぬᝅࢆỴࡵ࡚ࡸࡿ࡜࠸࠺ឤࡌ࡛ࡸࡗ࡚࠸
ࡿ࡜ᛮ࠸ࡲࡍࠋ
㸦Ⲩᮌ㸧 ᑠࡉ࠸࡜ࡇࢁࡔ࡜⤖ᵓࡁࡘ࠸ࡢ࡛ࡍࡡࠋ࠺ࡕ࡞࡝࡛ࡶ 㸣☜ಖࡋ࡚࠸ࡲࡍࡀࠊ
࡜࠸࠺ࡇ࡜ࡣࠊ࠿࡞ࡾࡢ㒊ศࢆࢸࢽࣗ࢔ࢺࣛࢵࢡ࡛ࡸࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍࡡࠋ㸦すᮧ㸧 ࡑ࠺ࡍࡿ࡜ࠊ᪂ࡋ࠸ே஦ࡢ౛࠼ࡤᩍᤵࡀฟࡽࢀ࡚ࡶࠊ᪂ࡋࡃ㑅ࡪ࡜࠸࠺ࡢࡣ࠿࡞ࡾࠋ
㸦Ⲩᮌ㸧 ௒ࡕࡻࡗ࡜Ṇࡲࡗ࡚࠸ࡲࡍࡡࠋ㸦すᮧ㸧 ࡛ࡍࡼࡡࠋࡔ࠿ࡽࠊࡑ࠺࠸࠺ព࿡࡛኱ࡁࡃ◊✲ᡤࡢ᪉ྥࢆ⪃࠼࡞࠸࡜ࠊ࡞࠿࡞࠿
㞴ࡋ࠸࠿ࡶࡋࢀࡲࡏࢇࠋ
㸦᳃㸧 ࡔ࠿ࡽࠊࢸࢽࣗ࢔ࢺࣛࢵࢡ࡛࡝࠺࠸࠺ேࢆ㑅ࡪ࠿࡜࠸࠺࡜ࡇࢁࠊ౛࠼ࡤ࠺ࡕࡔࡗࡓ
ࡽ⌮Ꮫ◊✲⛉⏕࿨⌮Ꮫᑓᨷ࡜࠸࠺࡜ࡇࢁࡀ࡝࠺࠸࠺᪉ྥ࡟⾜ࡃ࠿࡜࠸࠺ࡇ࡜ࢆࠊࡶ࠺᪤࡟ࠋ
− 86 −

㸦ᒣᮏ㸧 ᑗ᮶ᵓ᝿ࡀ࠿࠿ࡗ࡚ࡋࡲࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦᳃㸧 ࡑ࠺࠸࠺ࡇ࡜࡛ࡍࠋᙜ↛㸳ᖺᚋࡶࢡࣜ࢔࡛ࡁࡿࡔࢁ࠺࡜࠸࠺ண᝿࡛ࡸࡿࡢ࡛ࡍࡀࠊ
ࡑ࠺࡛ࡣ࡞࠸ேࡶ࠸ࡲࡋࡓࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺ᙧ࡛ࢸࢽࣗ࢔ࢺࣛࢵࢡࢆࡸࡗ࡚ࠊ࠶ࡿព࿡࡛
ࡣ࡝࠺࠸࠺ேࢆ㞠⏝ࡍࡿ࠿࡛࡯࡜ࢇ࡝Ỵࡲࡗ࡚ࡋࡲ࠸ࡲࡍࡡࠋ㸦すᮧ㸧 ཧ⪃࡟ࡋ࡚ࠊ௒ᚋᇶ⏕◊࡛࡝ࡢࡼ࠺࡟ே஦ࢆ⾜ࡗ࡚࠸ࡃ࠿࡜࠸࠺࡜ࡇࢁ࡟཯ᫎࡋ
ࡓ࠸࡜ᛮ࠸ࡲࡍࠋ⚾ࢆྵࡵ࡚⣽⬊⣔ࡢᩍᤵࡀ㸰ே஺௦ࡋࡲࡍࡢ࡛ࠊே஦ࡀࡲࡓᗄࡘ࠿ጞࡲࡿ
࡜ᛮ࠸ࡲࡍࡢ࡛ࠊࡑࢀࢆཧ⪃࡟ࡋ࡚ᑡࡋ㆟ㄽࢆࡍࡿᚲせࡀ࠶ࡾࡑ࠺࡛ࡍࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ㸦すᮧ㸧 ᪂㡿ᇦ࡟㛵ࡋ࡚ࡣࠊࡼࢁࡋ࠸࡛ࡍ࠿ࠋ
㸦᳃㸧 ౛࠼ࡤ᳜≀ࡢ࠺ࡕࡢᮾᒣဴஓࡉࢇ࡞࡝ࡣ  ṓࡄࡽ࠸࡛ᩍᤵ࡛ࡍࡼࡡࠋᑗ᮶᭷ᮃࡔ࡜
࠸࠺ࡇ࡜࡛ࠊ௒ࠊWPI ࡢ๪ᣐⅬ㛗࡛ࠊࡑ࠺࠸࠺ᙧ࡛ࡣ㠀ᖖ࡟ά㌍ࡉࢀ࡚࠸ࡲࡍࠋࡑ࠺࠸࠺ே
ࢆ᥇ࡗ࡚࠸ࡲࡍࠋࡑࢀࡣṇつࡢ࣏ࢪࢩࣙࣥࡔࡗࡓࡢ࡛ࡍࡀࠊ㸳㹼㸴ᖺ๓࡟ࡑ࠺࠸࠺ࡇ࡜ࢆぢ㉺ࡋ࡚ࠊ᪂ࡋ࠸ศ㔝ࡢ㛤ᣅ⪅࡛࠶ࡿ࡜࠸࠺ࡇ࡜ࡶ⪃࠼࡞ࡀࡽࠊࡑ࠺࠸࠺᪉ྥ࡛ࠊྡྂᒇ኱Ꮫ
ࡢᑗ᮶ࢆỴࡵࡿே࡛࠶ࡿ࡜࠸࠺ࡇ࡜ࡶ⪃࠼࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࡡࠋ
㸦㛗㇂㸧 ඲࡚ࡢ⤌⧊ࡀࡇࢀ࠿ࡽࡑ࠺࠸࠺ேࢆ᥇⏝ࡋࡓ࠸࡜ᛮ࠺ࢃࡅ࡛ࠋ
㸦᳃㸧 ⤯ᑐ࡟➇த࡟࡞ࡿ࡜ᛮ࠸ࡲࡍࠋ
㸦㛗㇂㸧 ࡑࢀࡣ㛫㐪࠸࡞࠸ࢃࡅ࡛ࡍࠋࡔ࠿ࡽࠊே࡟ᑐࡍࡿ┠฼ࡁ࡜ศ㔝࡟ᑐࡍࡿ┠฼ࡁࢆ࡝ࡢࡼ࠺࡞ᙧ࡛ࡍࡿ࠿࡜࠸࠺ࡢࡣ኱ኚ㞴ࡋ࠸࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ㸦ሷぢ㸧 ൅ࡶࡇࡢ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࡣ࡜࡚ࡶ㔜せࡔ࡜ᛮ࠸ࡲࡍࠋ௒ࡔࡗࡓࡽḟୡ௦ࢩ࣮ࢣࣥࢧ࣮࡜ TALEN ࡜ CRISPR ࡜ RNAi ࢆ౑࠼ࡤࠊᴟ➃࡟ゝ࠼ࡤࠊ࡝ࢇ࡞ࡶࡢ࡛ࡶ
ࣔࢹࣝ⏕≀࡟࡞ࡾᚓࡿࢃࡅ࡛ࡍࠋࡔ࠿ࡽࠊ࡝࠺࠸࠺ศ㔝ࢆⓎᒎࡉࡏ࡚࠸ࡁࡓ࠸࠿࡟ࡼࡗ࡚ࠊ
ࡑࡢேࡀࣔࢹࣝື≀࡜ࡋ࡚ఱࢆ౑ࡗ࡚࠸ࡼ࠺ࡀࠊࡑ࠺࠸࠺ேࢆ᥇ࡗ࡚ࡁ࡚ఙࡤࡋ࡚࠸ࡃ࡜࠸
࠺ࡇ࡜࡛ࡍࠋࡑࢀ࡛௒ࡲ࡛ࡢ࠸ࢃࡺࡿྂ඾ⓗ࡞ࣔࢹࣝື≀ࠊ࣐࢘ࢫ࡜࠿ࠊࢩࣙ࢘ࢪࣙ࢘ࣂ࢚
࡜࠿ࠊࡶࡋ࠿ࡋࡓࡽ⥺⹸࡞࡝ࡶධࡿ࠿ࡶࡋࢀࡲࡏࢇࡀࠊࡑ࠺࠸࠺ࡶࡢ࡛ࡣ࡞࠿࡞࠿ࣈ࣮ࣞࢡ
ࢫ࣮ࣝࡀ㞴ࡋ࠸ࡼ࠺࡞ศ㔝࡛ࠊ௒ࡲ࡛ㄡࡶ▱ࡽ࡞࠸ࡼ࠺࡞⏕ࡁ≀ࢆ౑࠼ࡤពእ࡟஌ࡾ㉺࠼ࡽࢀࡓࡾࠋ

− 87 −

㸦ᒣᮏ㸧 ▱ࡽ࡞࠸⏕≀࠿▱ࡗ࡚࠸ࡿ⏕≀࠿ࡣู࡜ࡋ࡚ࠊ࡝࠺࠸࠺⏕࿨⌧㇟࣭⏕≀⌧㇟ࢆࡇࢀ࠿ࡽゎ᫂ࡋࡼ࠺࠿࡜࠸࠺ࡇ࡜࡛ࡍࡼࡡࠋࡑࢀ࡟ྜࡗࡓࣔࢹࣝࢆ㛤Ⓨࡍࡿ࡜࠸࠺Ⓨ᝿࡟࡞ࡿ࡜ᛮ࠺ࡢ࡛ࡍࠋ㸦すᮧ㸧 ㈗㔜࡞ࡈពぢࢆ㡬ࡁࡲࡋ࡚࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋϬ ⱝᡭ◊✲⪅ࡢ⫱ᡂ㸦すᮧ㸧 ࡑࢀ࡛ࡣࠊ᭱ᚋࡢⱝᡭࡢ◊✲⪅ࡢ⫱ᡂࡢ࡜ࡇࢁ࡟ධࡾࡓ࠸࡜ᛮ࠸ࡲࡍࡀࠊ㈨ᩱ㸯
ࡢ 3 ࡜㈨ᩱ㸱ࡢ 3 ࢆࡈぴୗࡉ࠸ࠋ⡆༢࡟ࡈㄝ᫂ࡋࡲࡍࠋ
 ௒ࠊᢸᙜᩍဨࡣᇶ⏕◊ࡢᩍᤵࠊ෸ᩍᤵࠊຓᩍ඲࡚࡛  ྡ࠾ࡾࡲࡋ࡚ࠊ኱Ꮫ㝔⏕ࡶࢺ࣮ࢱࣝ
ࡢᐃဨ࡜ࡋ࡚ࡣ  ྡ࡛ࠊࡑࡢ୰࡛  ྡࡀᅾ⡠ࡋ࡚࠾ࡾࡲࡍࠋࡇࡇ㸰ᖺࡄࡽ࠸ධᏛ⪅ࡀ ྡ௨ୖࡢࡼ࠺࡞ᙧ࡛ቑ࠼࡚ࡁ࡚࠾ࡾࡲࡍࠋ࡞ࡐቑ࠼࡚ࡁࡓ࠿ࡣࡶ࠺୍ࡘゎᯒࡣࡋษࢀ࡚࠸࡞
࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊ๓࡟࠾ヰࡋࡋࡓ኱Ꮫ㝔⏕ྥࡅࡢኟࡢᐇ⩦ࢆ⾜ࡗ࡚࠾ࡾࠊࡑࡢᙳ㡪ࡀ࠿࡞ࡾ࠶ࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮ࠸ࡲࡍࠋ኱Ꮫ㸯㹼㸰ᖺ⏕࡟ྥࡅ࡚ࡢ኱Ꮫ⏕ࡢࡓࡵࡢኟࡢᐇ⩦࡜࠸࠺ࡇ࡜࡛ࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࡛⾜ࡗ࡚࠾ࡾࡲࡍࠋ ኱Ꮫ㝔ᩍ⫱࡜ࡋ࡚ࡣࢺ࣮ࢱࣝ࡜ࡋ࡚ࠊᇶ⏕◊ࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ⼥ྜࡢࣉࣟࢢ࣒ࣛࢆᚎࠎ࡟
ᑟධࡋ࡚࠸ࡗ࡚࠾ࡾࠊ≉࡟⤫ྜ⏕࿨⛉Ꮫᩍ⫱ࣉࣟࢢ࣒ࣛࠊࡑࡋ࡚⬻⛉Ꮫ࡜࠸࠺ᑓᨷ㛫⼥ྜࣉࣟࢢ࣒ࣛࡀ࠶ࡾࡲࡍࡀࠊࡇࡢࡼ࠺࡟ᇶ♏⏕≀Ꮫᑓᨷࡔࡅ࡛ࡣ࡞ࡃ⏕⌮⛉Ꮫᑓᨷ࡜ศᏊ◊ࡢᑓ
ᨷ࡜ඹ㏻࡛ࣉࣟࢢ࣒ࣛࢆ㉮ࡽࡏࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜ࡀ⾜ࢃࢀ࡚࠾ࡾࡲࡍࠋࡑࢀࡀ୍ࡘࡢ᪂ࡋ
࠸᪉ྥ࡛ࡍࠋ
 ࡲࡓࠊ≉ูඹྠ฼⏝◊✲ဨࢆ௒⌧ᅾ㸷ྡࠊ௚኱Ꮫ࠿ࡽཷࡅධࢀ࡚࠾ࡾࡲࡍࠋ኱Ꮫ㝔⏕࡟㛵ࡋ࡚ࡣ࡯ࡰ๓ᮇ㸦ಟኈ㸧ㄢ⛬࠿ࡽᖺ㛫  ୓෇ࡢ཰ධࡀᚓࡽࢀࡿࡼ࠺࡟࡜࠸࠺ࡇ࡜࡛ࣜࢧ࣮ࢳ
࢔ࢩࢫࢱࣥࢺࡢไᗘࢆᑟධࡋ࡚࠾ࡾࡲࡍࠋ
 ௚኱Ꮫ࡜ࡢ㐃ᦠ࡜࠸࠺ࡇ࡜࡛ࡣࠊྡྂᒇ኱Ꮫࡢ᳃ඛ⏕ࡢ࡜ࡇࢁ࡜ࢢ࣮ࣜࣥ⮬↛⛉Ꮫᅜ㝿ᩍ⫱◊✲ࣉࣟࢢ࣒ࣛࢆᥦᦠࡉࡏ࡚࠸ࡓࡔ࠸࡚࠾ࡾࠊ≉࡟ྡྂᒇ኱Ꮫ⌮Ꮫ◊✲⛉ࡢᏛ⏕ࡉࢇࡢ༞ᴗ◊✲ࢆᇶ⏕◊ࡢ᪉ࡢ௵ពࡢ◊✲࡛⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࡼ࠺࡞ไᗘࢆసࡗ࡚࠾ࡾࡲࡍࠋࡇࡢࡇ
࡜࠿ࡽ௒ࠊྡྂᒇ኱Ꮫ࠿ࡽ㸯ྡࠊࡑࢀ࠿ࡽᮾி⌮⛉኱Ꮫ࠿ࡽ㸯ྡࡢᏛ⏕ࢆཷࡅධࢀ࡚࠸ࡲࡍࠋ
 ࡇࡢ୰࡛ࠊඛ࡯࡝ฟ࡚࠸ࡓ⊂❧෸ᩍᤵࡢ୍ࡘࡢၥ㢟ⅬࡣࠊᏛ⏕ࡀ࡞࠿࡞࠿ྲྀࢀ࡞࠸࡜࠸࠺
ࡇ࡜࡛ࡍࠋࡑࢀ࡛࠶ࡲࡾ኱ࡁ࡞ࢢ࣮ࣝࣉ࡛ࡸࢀ࡞࠸࡜࠸࠺ࡇ࡜ࡀ࠶ࡗࡓࡢ࡛ࡍࡀࠊᮾி⌮⛉኱ᏛࡢᏛ⏕ࡉࢇࡀ⊂❧෸ᩍᤵࡢ᪉࡟௜࠸࡚࠸࡚ࠊ᭱㏆ࡣẚ㍑ⓗࠊ༤ኈㄢ⛬ࡢᏛ⏕ࡉࢇࡶ⊂❧෸ᩍᤵࡢேࢆᣦᑟᩍဨ࡜ࡋ࡚ධࡗ࡚ࡃࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠋ࡛ࡍ࠿ࡽࠊ᭱ึࡣ࡯࡜ࢇ࡝࡞࠿
ࡗࡓࡢ࡛ࡍࡅࢀ࡝ࡶࠊ
᭱㏆ቑ࠼࡚ࡁ࡚࠸ࡿࡢ࡛ࠊ
ᑡࡋ≧ἣࡣኚࢃࡗ࡚ࡁࡓ࠿࡞࡜࠸࠺ࡇ࡜࡛ࠊ
⊂❧෸ᩍᤵࡢேࡶ◊✲ࢆⓎᒎࡉࡏ࡚࠸ࡅࡿࡢ࡛ࡣ࡞࠸࠿࡜⚾ࡣ⪃࠼࡚࠾ࡾࡲࡍࠋ
 ࡑࢀ࠿ࡽࠊྡྂᒇᕤᴗ኱Ꮫ࡜㐃ᦠࡋ࡚ࠊࡇࢀࡶඹྠ◊✲࡜࠸࠺ࡇ࡜࡛Ꮫ఩ྲྀᚓ⪅ࡀ⏕ࡲࢀ

− 88 −

࡚ࡁ࡚࠸ࡿ࡜࠸࠺ࡼ࠺࡞ࡇ࡜࡛㐃ᦠࢆ㐍ࡵ࡚࠸ࡃ࡜࠸࠺ࡇ࡜࡛ࡍࠋ඲࡚ࡢ◊✲ᶵ㛵࡛ྠࡌࡼ࠺࡟኱Ꮫ㝔⏕ࡸⱝᡭ◊✲⪅ࡢ㣴ᡂ࡟㛵ࡋ࡚ࡣ㔜せ࡞ㄢ㢟ࡔࢁ࠺࡜ᛮ࠸ࡲࡍࡢ࡛ࠊఱ࠿࠸࠸᪉
ἲࠊ࠸࠸࢔࢖ࢹ࢔ࡀࡈࡊ࠸ࡲࡋࡓࡽࡈᣦ᦬࠸ࡓࡔࡅࢀࡤ㠀ᖖ࡟࠶ࡾࡀࡓࡃᛮࡗ࡚࠾ࡾࡲࡍࠋ ኱Ꮫ㝔࡟㛵ࡋ࡚ࠊⱝᡭ◊✲⪅ࡢ⫱ᡂ࡜࠸࠺ࡇ࡜࡟㛵ࡋ࡚ࡈពぢࠊࡈ㉁ၥ➼ࡀࡈࡊ࠸ࡲࡋࡓ
ࡽ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ
㸦㛗㇂㸧 Ꮫ⏕ࡢᐃဨ࡜ᅾ⡠⪅ࢆࡶ࠺୍ᅇ☜ㄆࡋࡓ࠸ࡢ࡛ࡍࡀࠊ㈨ᩱ㸱ࡢ 3 ࡟࠶ࡿࡼ࠺
࡟㸳ᖺ୍㈏ไࡢ༤ኈㄢ⛬࡜༤ኈᚋᮇㄢ⛬ࢆ஧ࡘే⏝ࡋ࡚ᣢࡗ࡚࠾ࡽࢀࡿࢃࡅ࡛ࡍࡡࠋ㸦すᮧ㸧 ࡣ࠸ࠋ㸳ᖺ୍㈏ไࢆ㏵୰࠿ࡽᑟධࡋࡲࡋࡓࠋ㸱ᖺḟ⦅ධ࡜࠸࠺༤ኈᚋᮇㄢ⛬ࡀ㸯ᖺ࡟㸴ேࡢᐃဨ࡛ࡍࠋ㸳ᖺ୍㈏ไࡣ㸯ᖺ࡟㸱ྡ࡜࠸࠺ࡇ࡜࡛ࡍࡢ࡛ࠊࢺ࣮ࢱ࡛ࣝࡣ  ྡࡀᐃဨ࡟࡞ࡾࡲࡍࠋࡑࢀ࡛ࠊ⌧ᅾࡢᅾ⡠ᩘࡣ㸳ᖺ୍㈏ไࡀ  ྡࠊ㸱ᖺḟ⦅ධࡀ  ྡ࡛⥲ィ ྡ࡟࡞ࡾࡲࡍࠋ㸱ᖺḟ⦅ධ࡜㸳ᖺ୍㈏ไࢆ୪ิࡉࡏࡿ࡜࠸࠺≉ูࡢࢩࢫࢸ࣒ࢆタࡅ࡚ࠊ ᖺ࡛ಟኈࢆ࡜ࡗ࡚ࡸࡵࡿ࡜࠸࠺ࡼ࠺࡞Ꮫ⏕ࡣ࠶ࡲࡾ࡛࡚ࡇ࡞࠸ࡼ࠺࡞ᙧࢆ࡜ࡗ࡚࠸ࡲࡍࠋ
㸦㛗㇂㸧 ࡶ࠺௒ࠊ኱Ꮫ࡛⏕࿨⣔ࡣࢻࢡࢱ࣮ࢥ࣮ࢫࠊ࠶ࡿ࠸ࡣᚋᮇㄢ⛬ࡢᏛ⏕඘㊊⋡ࡣ 㸣ࢆษࡾࡘࡘ࠶ࡾࡲࡍࡡࠋ࡝࠺ࡋ࡚ࡶ⏕≀⣔࡛ࡣᅇ᚟ࡣ࡯࡜ࢇ࡝୙ྍ⬟࡛ࠊࡴࡋࢁᐃဨࢆῶࡽ
ࡋ࡚ࡶࡽ࠸ࡓ࠸࡜࠸࠺ࡄࡽ࠸ࡢẼᣢࡕࡀᙉ࠸ࡢ࡛ࡍࡀࠊࡇࡇࡣࡑ࠺࡛ࡣ࡞ࡃ࡚ࠊ㝶ศከ࠸ࠋ
㸦ᒣᮏ㸧 ࡇࡇ㸰㹼㸱ᖺࠊ㠀ᖖ࡟㡰ㄪ࡟ఙࡧ࡚ࡁ࡚ࠊ༑ఱྡࡎࡘධࡗ࡚ࡁ࡚࠸ࡲࡍࠋࡓࡔࠊ
ࡑࡢᑡࡋ๓ࡀࠊࡸࡣࡾ㏵୰࡛ࡸࡵࡿ᪉ࡀఱே࠿࠸࡚ࠊࡑࢀ࡛ࢺ࣮ࢱࣝ࡜ࡋ࡚ࡣࡇࡢࡄࡽ࠸ࡢ
ᙧ࡟࡞ࡿ࡜ࠋ
㸦㛗㇂㸧 ࡞ࡿ࡯࡝ࠋ㈨ᩱ㸱ࡢ 3 ࡟ᐇ㝿࡟ேᮦ㍮ฟ࡜࠸࠺ᙧ࡛❧ὴ࡞ᐇ⦼ࢆ᭩࠸࡚࠾ࡽ
ࢀࡿࡢ࡛ࡍࡀࠊ࠸ࢃࡺࡿࣇࣝᐃဨ࡛ࢻࢡࢱ࣮ࢆฟࡋࡓሙྜ࡟ࠊ඲࡚ࡢ᪉࡟ḟࡢ࣏ࢪࢩࣙࣥࡀ
࠶ࡗ࡚࡜࠸࠺ࡼ࠺࡞㐠⏝ࢆࡉࢀ࡚࠸ࡿࡢࡔ࡜ࡋࡓࡽࠊࡸࡣࡾ≉ẁࡢດຊࢆࡉࢀ࡚࠸ࡿ࡟㐪࠸࡞࠸࡜ᛮ࠺ࢃࡅ࡛ࡍࡀࠋ㸦すᮧ㸧 ◊✲ᡤ࡛࡜࠸࠺ࡼࡾࡶࠊࡑࢀࡒࢀࡢ◊✲ᐊ࡛⾜ࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࡀࠊ
࠿࡞ࡾࡢ㒊ศࡀ◊✲⪅࡟࡞ࡗ࡚࠸ࡲࡍࠋ
㸦㛗㇂㸧 ࠶࠶ࠊࡑࢀࡣ❧ὴ࡛ࡍࡡࠋ
㸦ᒣᮏ㸧 ከศࠊ㛗㇂ඛ⏕ࡀࡈᚰ㓄࡞ࡢࡣࠊධࡗࡓேࡀ඲㒊ࡁࡕࢇ࡜ࢻࢡࢱ࣮ࡲ࡛ฟ࡚࠸ࡿ
࠿࡝࠺࠿࡜࠸࠺ࡇ࡜ࡔ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊࡑࡢⅬ࡟㛵ࡋ࡚ࡣၥ㢟ࡣෆᅾࡋ࡚࠾ࡾࡲࡍࠋ㸦すᮧ㸧 ࡇࡢ㸰ᖺࠊ㸱ᖺ࡛࡝ࡗ࡜  ྡ௨ୖࡀධࡗ࡚ࡁ࡚࠸ࡲࡍࡀࠊࡑࡢேࡓࡕࡀࡁࡕࢇ࡜
ࢻࢡࢱ࣮ࢆྲྀࡗ࡚ฟ࡚⾜ࡗ࡚࡜࠸࠺ࡼ࠺࡟࡞ࡗ࡚ࡃࡿ࠿࡝࠺࠿ࡣࠊ௒ᚋࠊᇶ⏕◊኱Ꮫ㝔ᩍ⫱ࡢ㘽࡟࡞ࡗ࡚ࡃࡿ࡜ᛮ࠸ࡲࡍࠋ

− 89 −

㸦᳃㸧 ࡇࡢ 3 ࡣᇶᮏⓗ࡟࢔࢝ࢹ࣑࢔ࡢ᪉ࡓࡕ࡛ࡍࡡࠋ㸦すᮧ㸧 ࡣ࠸ࠋ㸦᳃㸧 ࡑ࠺࠸࠺᪉ࡀࡸࡣࡾከ࠸ࡢ࡛ࡍ࠿ࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋᐇ㝿࡟ᑵ⫋ࡉࢀࡿࡢࡣ◊✲⪅ࡀᅽಽⓗ࡟ከ࠿ࡗࡓ࡛ࡍࠋࡓࡔࠊ᭱㏆ࡣࡸࡣࡾ࣏ࢫࢻࢡ࠿ࡽḟࡢࢸࢽࣗ࢔ࢆྲྀࡗ࡚࠸ࡃ࡜࠸࠺ࡼ࠺࡞࡜ࡇࢁࡀ㠀ᖖ࡟ཝࡋࡃ࡞ࡗ࡚
࠸ࡲࡍࡢ࡛ࠊࡑࡇࡢ࡜ࡇࢁࡣࡲࡔࠊ඲య࡜ࡋ࡚ࡑ࠺࡞ࡢ࡛ࡋࡻ࠺ࡅࢀ࡝ࡶࠊཝࡋ࠸≧ἣ࠿ࡶࡋࢀࡲࡏࢇࠋ
㸦᳃㸧 ࠺ࡕࡣࡑ࠺࡛ࡣ࡞ࡃ࡚ࠊ࣏ࢫࢻࢡࢆࡸࡗ࡚ࠊࡑࡢᚋࠊᾏእ࡟⾜ࡗ࡚࣏ࢫࢻࢡࢆࡸࡗ
࡚ࠊㄽᩥࢆ᭩ࡁࠊࡑࡢᚋࠊ௻ᴗ࡞࡝ࡢ◊✲⪅࡟࡞ࡿேࡀ⤖ᵓከࡃ࡚ࠊ࣋ࣥࢳ࣮ࣕࡶከ࠸࡛ࡍ
ࡡࠋ࠶࡜ࡣ⛉Ꮫࢪ࣮ࣕࢼࣜࢬ࣒࡟⾜ࡗ࡚ࡋࡲ࠺࡜࠿ࠊ࠸ࢁ࠸ࢁከࡃ࡚ࠊ⏘ᐁᏛࡢ࡜ࡇࢁ࡟ᕼ
ᮃࡋ࡚⾜ࡃ࡜࠿ࠋ㸦すᮧ㸧 ࡑࢀࡣࢻࢡࢱ࣮ࢆྲྀࡗ࡚࠿ࡽ࡛ࡍ࠿ࠋ
㸦᳃㸧 ࡶࡕࢁࢇ༤ኈྕࢆྲྀࡗ࡚࠿ࡽ࡛ࡍࠋ㸦すᮧ㸧 ࡑࡢ㒊ศࡣࠊ኱Ꮫࡢᩍဨࡀ࠶ࡿ⛬ᗘࢧ࣏࣮ࢺࡍࡿࡢ࡛ࡋࡻ࠺࠿ࠋ
㸦᳃㸧 ࢧ࣏࣮ࢺ࡜࠸࠺࠿ࠊ⮬ศ࡛Ỵࡵ࡚ࡋࡲ࠺ࠋᑡ࡞ࡃ࡜ࡶ࠺ࡕࡢ◊✲ᐊࡣ⮬ศ࡛ࡳࢇ࡞
຾ᡭ࡟Ỵࡵ࡚ࠊࡑࢀ࡞ࡾ࡟ࢧࢡࢭࢫࣇࣝ࡟ࡸࡗ࡚࠸ࡲࡍࡡࠋ
㸦Ⲩᮌ㸧 ࡛ࡶࠊྡྂᒇ኱Ꮫࡣ࣐ࢵࢳࣥࢢࡢ௙⤌ࡳࢆ࠾ᣢࡕ࡛ࡋࡻ࠺ࠋ఍♫࡜ࢻࢡࢱ࣮ࢆྲྀ
ࡗࡓ࣏ࢫࢻࢡࡢேࡓࡕࡢࠋ
㸦㛗㇂㸧 ࢖ࣥࢱ࣮ࣥࢩࢵࣉ࡜࠿ࠊࡑ࠺࠸࠺ࡶࡢࡢไᗘ࡛ࡍࡡࠋ
㸦᳃㸧 ࣮ࣜࢹ࢕ࣥࢢ኱Ꮫ㝔࡜࠿ࠊࢢ࣮ࣟࣂࣝ COE ࡜࠿ࠊࡑࢀࡣ࠶ࡾࡲࡍࠋ
㸦ྜྷ⏣㸧 ௻ᴗ࡜ࡢ࣐ࢵࢳࣥࢢࡣ࡝࠺࡛ࡍ࠿ࠋ
㸦᳃㸧 ࡑࢀࡣ⏕≀⣔࡞ࡢ࡛ṇ┤ᙅ࠸࡛ࡍࠋࡑࢀࡣ࡞࠸࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 ࠸ࡸࠊࡔ࠿ࡽ኱Ꮫ࡟ࡑ࠺࠸࠺⤌⧊ࡀ࠶ࡗ࡚ࡸࡗ࡚࠸ࡽࡗࡋࡷࡿ࡜ᛮ࠺ࡢ࡛ࡍࠋ
㸦᳃㸧 ࡸࡗ࡚࠸ࡿࡢ࡛ࡍࡀࠊࡑࡇ࡟㢗ࢇ࡛ࡶᇝࡀ᫂࠿࡞࠸࡜࠸࠺ࡇ࡜ࡣࡕࡻࡗ࡜࠶ࡾࡲࡋ
࡚ࠊ࠶ࡲࡾ࠺ࡲࡃ࠸ࡗ࡚࠸࡞࠸࡜⪺࠸࡚࠸ࡲࡍࡡࠋ⚾ࡢ࿘ࡾ࡛ࡍࡀࠊࡑࡇ⤒⏤࡛ᑵ⫋ࢆࣀࣥ− 90 −

࢔࢝ࢹ࣑࢔࡛Ỵࡵࡓேࡣᐇࡣ࠸࡞ࡃ࡚ࠊ⮬ศ࡛຾ᡭ࡟Ỵࡵ࡚ࡁࡓ࡜࠸࠺ேࡀከ࠸࡛ࡍࡡࠋ
㸦㛗㇂㸧 ࠶࡜ࡣⱝᡭࡢ◊✲⪅ࡢ⫱ᡂ࡜࠸࠺ᙧ࡛≉௵◊✲ဨࡢ᪉ࢆࡓࡃࡉࢇ㞠⏝ࡉࢀ࡚࠾ࡽ
ࢀࡿࢃࡅ࡛ࡍࡡࠋࡇࡇ࡛ゝ࠼ࡤ  ྡࡄࡽ࠸ࡢ≉௵◊✲ဨࡢ᪉ࢆࠋ㸦すᮧ㸧 ࡑࢀࡣ NIBB ࣜࢧ࣮ࢳࣇ࢙࣮࡛ࣟࡍࡡࠋ
㸦㛗㇂㸧 Ꮫ⏕ࡉࢇ࡛ࡣ࡞ࡃ࡚ࠊ࣏ࢫࢻࢡ࡛ࡍࡼࡡࠋࡑࢀࡶ኱ኚࠊ኱Ꮫ࡜ࡋ࡚ࡣ㔜せ࡞࡜ࡇࢁ࡛ࠊ ྡࡢ◊✲ဨࠊ≉௵ࢆྵࡴࠊࣜࢧ࣮ࢳࣇ࢙࣮ࣟࡢᩘࢆ♧ࡍ⾲㸦㈨ᩱ㸱3㸧࡛ࡍࡅࢀ࡝ࡶࠊ≉௵◊✲ဨࡢ᪉࡜࠸࠺ࡢࡣ㐠Ⴀ㈝஺௜㔠ࠊ࠶ࡿ࠸ࡣඛ⏕ࡢእ㒊㈨㔠࡛㞠ࢃࢀ࡚࠸ࡿ
᪉࡛ࡍࡡࠋࡇ࠺࠸࠺᪉ࡣࠊ౛࠼ࡤ⛉Ꮫ◊✲㈝⿵ຓ㔠ࡀ⏦ㄳ࡛ࡁࡿࡼ࠺࡞ࢩࢫࢸ࣒࡛㞠⏝ࡉࢀ࡚࠸ࡿࡢ࡛ࡋࡻ࠺࠿ࠋ㸦すᮧ㸧 ࡑࢀࡣ NIBB ࣜࢧ࣮ࢳࣇ࢙࣮ࣟࡀ㐠Ⴀ㈝஺௜㔠࡛ࡢ㞠⏝࡛ྛ㒊㛛㸯ྡ࡜࠸࠺ᙧ࡛
㓄⨨ࡋ࡚࠸ࡲࡍࠋ
㸦㛗㇂㸧 ࡑࢀࡣ኱୔ኵ࡛ࡍࡡࠋእ㒊㈨㔠࡛ࠋ㸦すᮧ㸧 ࡑࢀ࠿ࡽࠊᐇ㝿࡟ࡇࡇࡢࡑࢀࡒࢀࡢ⛉◊㈝࡛㞠ࢃࢀ࡚࠸ࡿ࣏ࢫࢺࢻࢡࢺࣛࣝࣇ࢙
࣮ࣟࡶࠊࡇࡇࡢሙྜ࡟ࡣ▷᫬㛫ዎ⣙⫋ဨ࡜࠸࠺ᙧ࡟࡞ࡗ࡚࠾ࡾࡲࡋ࡚ࠊ࠶࡜ࡢ᫬㛫ࢆ≉ู༠ຊ◊✲ဨ࡜࠸࠺ᙧ࡛ࠊูࡢ◊✲ࡶ࡛ࡁࡿ௙⤌ࡳ࡟࡞ࡗ࡚࠸ࡲࡍࠋ
㸦㛗㇂㸧 ⫋ࡶ᣺ࡾศࡅ࡚ࠋ㸦すᮧ㸧 ᣺ࡾศࡅ࡚ࠊࡑࡇࡢ᫬㛫ࢆ౑ࡗ࡚⛉◊㈝ࢆ⏦ㄳ࡛ࡁࡿ࡜࠸࠺ᙧ࡟ࡋ࡚࠾ࡾࡲࡍࠋ
㸦㛗㇂㸧 ࡑ࠺࠸࠺⊂⮬◊✲ࢆᒎ㛤ࡍࡿ࡜࠸࠺ᙧ࡟ࡋ࡚ࡸࡗ࡚࠾ࡽࢀ࡚ࠊఱࢆ⚾ࡣぢ࡚࠸ࡿ࠿࡜࠸࠺࡜ࠊ⛉◊㈝ࣛࣥ࢟ࣥࢢࡢ⾲ࡀ㈨ᩱ㸱3 ࡟ฟ࡚࠾ࡾࡲࡍࡀࠊᇶ⏕◊ࡣ᥇ᢥ௳ᩘ࡛ ௳࡜࠸࠺ᩘᏐࡀฟ࡚࠸ࡿࢃࡅ࡛ࡍࡅࢀ࡝ࡶࠊࡇࡢ  ௳ࡢẕᩘ࡛ࡍࠋ㔠㢠࡛ࡣ࡞ࡃ࡚ࠊ௳
ᩘࢆ⪃࠼ࡿୖ࡛ࡢẕᩘ࡟≉௵◊✲ဨࡶࡶࡋධࡗ࡚࠸ࡿࡢࡔ࡜ࡍࢀࡤࠊⱝᡭࡢ᪉ࠎࡢ⛉◊㈝ࡢ
᥇ᢥ⋡ࡣ࠶ࡲࡾ㧗ࡃ࡞࠸ࡢ࠿࡞࡜࠸࠺ࡼ࠺࡟ぢ࡚ྲྀࢀࡿࢃࡅ࡛ࡍࠋ௚ࡢ኱Ꮫࡣ▱ࡾࡲࡏࢇࡅ
ࢀ࡝ࡶࠊ኱㜰኱Ꮫࡢ୰࡛᭱ࡶάⓎ࡟ࡸࡗ࡚࠸ࡿ⏕࿨⣔࡛࠶ࢀࡤࠊ඲࡚ࢆྵࡵ࡚㸯ேᙜࡓࡾ㸰௳࡜࠸࠺ࡼ࠺࡞⛉◊㈝ࡢ᥇ᢥ⋡ࢆ㄂ࡗ࡚࠸ࡿ࡜ࡇࢁࡶ࠶ࡾࡲࡍࡋࠊ⺮ⓑ◊ࡣ  ࡛ࡍࠋᇶ⏕◊࡛࠸ࡅࡤࠊ㔠㢠ࡣከ࠸࡛ࡍࡀࠊ㹼ࠊࡑࡢ㎶࡛ࡍࡼࡡࠋ࡜࠸࠺ࡇ࡜ࡣࠊⱝᡭࡢ᪉ࠎࡢ⛉◊㈝࡟ᑐࡍࡿ᥇ᢥ⋡ࡀ࠶ࡲࡾ࡞࠸ࡢ࠿࡞࡜ᛮࢃࢀࡲࡍࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ☜࠿࡟ࡑ࠺࡛ࠊᐇែ࡜ࡋ࡚᥇ᢥ⋡ࡶ⾲࡜ࡋ࡚ฟ࡚ࡁࡲࡍࡀࠊࡑࢀࡣ
ࡑࢇ࡞࡟ᇶ⏕◊ࡣ㧗ࡃ࡞࠸࡛ࡍࠋ௳ᩘᙜࡓࡾࡢ᥇ᢥ㔠㢠࡛ฟࡋ࡚࠸ࡲࡍ࠿ࡽࠊ୍ࡘ୍ࡘࡀ኱

− 91 −

ࡁ࠸ࡶࡢࡀྲྀࡽࢀ࡚࠸ࡿࡅࢀ࡝ࡶࠊ⤯ᑐࡢ᥇ᢥ⋡࡜ࡋ࡚ࡣࡑࢇ࡞࡟኱ࡁࡃࡣ࡞࠸࡜࠸࠺ࡢࡀ
⌧≧࡛ࡍࠋ
㸦㛗㇂㸧 ࡓࡔࠊእ㒊㈨㔠࡛㞠ࢃࢀ࡚࠸ࡿ᪉ࡀ᫬㛫ࢆࡁࡕࢇ࡜๭ࡾ᣺ࡗ࡚ࠊࡈ⮬㌟ࡢ⮬⏤࡞᫬㛫ࢆసࡗ࡚⛉◊㈝࡛ࡢ◊✲ࢆࡸࡿ࡜࠸࠺ࡇ࡜ࡀᯝࡓࡋ࡚࠸࠸ࡢ࠿࡝࠺࠿࡜࠸࠺ࡢࡣ኱ኚ␲
ၥࡀ࠶ࡿ࡜ࡇࢁ࡛ࡍࠋࡴࡋࢁඖࡢᮏົࡢࣉࣟࢪ࢙ࢡࢺ࡟ຊࢆὀ࠸࡛ࠊ㸣ࡑࢀ࡟ᑓᛕࡋ࡚࠸
ࡓࡔࡃ࡜࠸࠺᪉ࡀ⤌⧊࡜ࡋ࡚ࡣ࠸࠸ࡢࡔࢁ࠺࡜ᛮ࠺ࡢ࡛ࡍࡀࠊ᪥ᮏࡢไᗘ࡜ࡋ࡚ࡣࠊࡑ࠺࠸
࠺ே࡟ࡶఱ࠿㞠⏝᫬㛫ࡢ㝽㛫ࢆసࡗ࡚ࠊ⊂⮬࡟◊✲ࡍࡿ࡜࠸࠺ࡢࡀ࠶ࡿࢃࡅ࡛ࡍࠋ
࡛ࡍ࠿ࡽࠊᇶ⏕◊࡜ࡋ࡚ࡣࡑࢀࢆ᥇⏝ࡉࢀ࡚࠸ࡿࢃࡅ࡛ࡍࡡࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠊࡣ࠸ࠋ
㸦㛗㇂㸧 ࡑࡢ᪉ྥᛶࡣ࡝࠺࠿࡞࡜࠸࠺ࠊ㠀ᖖ࡟⣲┤࡞␲ၥ࡞ࡢ࡛ࡍࠋࡑ࠺࠸࠺௙⤌ࡳࢆ㐠⏝ࡉࢀࡿ୰࡛ࠊ◊✲௦⾲⪅࡜ࡋ࡚⊂⮬࡟◊✲ࡍࡿ࡜࠸࠺ࡼ࠺࡞⎔ቃ࡞ࡾࠊ᫬㛫࡞ࡾࠊ࠶ࡿ࠸
ࡣ⮬⏤ᗘࢆࠊ◊✲ᡤࡀᐇ㝿࡟୚࠼࡚ࠊ࢟ࣕࣜ࢔ࣃࢫࡢカ⦎ࢆࡋ࡚࠾ࡽࢀࡿࡢ࡛ࡋࡻ࠺࠿ࠋከ
ศ኱Ꮫࡢሙྜࡣ࠶ࡲࡾࡑࢀࡣ࡛ࡁ࡚࠸࡞࠸ࡢ࡛ࡍࠋ◊✲ᡤࡢᇶ⏕◊ࡀⱝᡭ࡟ᑐࡋ࡚㞮ᙧ࡟࡞ࡿࡼ࠺࡞ไᗘࢆᐇ㝿࡟ື࠿ࡋ࡚࠸ࡓࡔࡁࡓ࠸࡜࠸࠺ࡢࡀᕼᮃ࡞ࡢ࡛ࡍࠋぢ࠿ࡅࡔࡅࡢ◊✲௦⾲⪅ࡢ⤒Ṕࢆ✚ࡳୖࡆࡿ࡜࠸࠺ࡢ࡛ࡣ࡞ࡃ࡚ࠋ
㸦㔝⏣㸧 ࡓࡔࠊⱝ࠸ே࡟⛉◊㈝ࢆฟࡍࡼ࠺࡟ዡບࡍࡿ࡜࠸࠺ࡇ࡜ࡣࠊྲྀࡿ࡜ࡍࡈ࠸⮬ಙ࡟࡞ࡾࡲࡍࡡࠋࡑࢀ࠿ࡽࠊ⛉◊㈝ࡢ᭩ࡁ᪉ࡶఱᖺ࠿ࢺࣛ࢖࣭࢔ࣥࢻ࣭࢚࣮ࣛࢆࡋ࡞࠸࡜࡞࠿࡞
࠿᥇ᢥࡉࢀ࡞࠸ࡢ࡛ࠊ࠶ࢀࡣฟࡍࡼ࠺࡟ᩍ⫱ࡍࡿ᪉ࡀᮏேࡢࡓࡵ࡟ࡣ࡞ࡿࡼ࠺࡞Ẽࡀࡋࡲࡍࡡࠋ㸦㛗㇂㸧 ࡞ࡿ࡯࡝ࠋ
㸦᳃㸧 ౛࠼ࡤ኱Ꮫࡔ࡜ࡑ࠺࠸࠺ࡇ࡜ࡣ࡞࠸ࡢ࡛ࠊ࣏ࢫࢻࢡ࡜࠸࠺ࡼ࠺࡞◊✲ဨࡣࠊ౛࠼ࡤ
⚾ࡢࢢࣛࣥࢺ࡛㞠⏝ࡋ࡚࠸ࡲࡍࡼࡡࠋᐇࡣࡑ࠺࠸࠺ேࡀࠊ࢚ࣇ࢛࣮ࢺ࡜ࡋ࡚ࡣ 㸣⛉◊㈝࡛࠶ࡿࡢ࡛ࠊᅵ᪥࡟ࡸࡿ࡜࠿ࠊ㸴᫬௨㝆࡟ࡸࡿ࡜࠿࡜࠸࠺ࡇ࡜࡛ⱝᡭ࡛ฟࡋࡓࡽ㏻ࡗࡓࡢ࡛
ࡍࠋ⚾ࡣࠕ㸣ࠊྩࡣⴠࡕࡿࠖ࡜ゝࡗ࡚࠸ࡓࡢࡀࠕ㏻ࡾࡲࡋࡓࠖ࡜ゝࢃࢀ࡚ࠊࠕ࠾࠾ࠊ⣲ᬕࡽ
ࡋ࠸ࠖ࡜ᛮࡗ࡚ࠋ
㸦㛗㇂㸧 ࡔ࠿ࡽࠊࡑࡇࡣ㠀ᖖ࡟༴࡞࠸ᶫࢆΏࡗ࡚࠸࡚ࠊ ᫬㛫௨ୖࡢศࡣࠊ⮬ศࡢ㊃࿡࡛ࡸࡿ࠿ࡽ㞠⏝ࡣ࡞ࡃ࡚ࡸࢀࡿ࡜࠸࠺ࡶࡢࡢ⪃࠼᪉࡞ࡢ࡛ࡍࡼࡡࠋ
㸦ᒣᮏ㸧 ࡇࢀࡣᏛ᣺࡞ࡾࠊᩥ⛉┬ࡀࡑࡢࡼ࠺࡞ࡶࡢࢆㄆࡵࡓ࡜࠸࠺ࡇ࡜࡛ࡍࡼࡡࠋ
㸦㛗㇂㸧 ࡑ࠺࡛ࡍࡡࠋ

− 92 −

㸦ᒣᮏ㸧 ᫇ࡣ㥏┠ࡔࡗࡓࡢ࡛ࡍࡼࡡࠋ࡛ࡶࠊ௒ࡣእ㒊㈨㔠࡛㞠⏝ࡉࢀ࡚࠸ࡿேࡶฟࡋ࡚࠸
࠸࡛ࡍࡼ࡜࠸࠺ࡇ࡜࡟࡞ࡿ࡜ࠊࡸࡣࡾᶒ฼ࡀ࠶ࡿ࡜࠸࠺ᙧ࡟࡞ࡾࡲࡍ࠿ࡽࠋ
㸦㛗㇂㸧 ࡑࢀࡣ኱ࡁ࠸࡛ࡍࡼࡡࠋ
㸦᳃㸧 ࡛ࡶࠊNIBB ࣜࢧ࣮ࢳࣇ࢙࣮ࣟ࡜࠸࠺㌟ศ࡜ࡋ࡚ࡢไ⣙ࡀ࠶ࡾࡲࡍࡼࡡࠋ
㸦ᒣᮏ㸧 ࢚ࣇ࢛࣮ࢺࡣ 㸣ࠊ௒ࡣ⁫ᅾ᫬㛫ࢆ᭩࠿࡞࠸࡜࠸ࡅ࡞ࡃ࡞ࡗ࡚࠸ࡲࡍ࠿ࡽࠊእ
㒊㈨㔠࡛㞠ࢃࢀ࡚࠸ࡿ᪉ࡣ໅ົ᫬㛫ࡣ 㸣ࡑࡢ௙஦ࢆࡸࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࠊゝࢃࢀࡓࡼ࠺࡟ࠊᅵ᭙᪥࡜࠿ࠊ᫬㛫እ࡜࠿ࠊࡑ࠺࠸࠺࡜ࡁ࡟⮬ศࡢ◊✲ࢆࡸࡗ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ
㸦᳃㸧 ኱Ꮫࡔ࡜ࡑ࠺࡛ࡍࠋNIBB ࣜࢧ࣮ࢳࣇ࢙࣮ࣟ࡜ࡋ࡚ࡢ᫬㛫ⓗไ⣙ࡣ࡝࠺࡞ࡢ࡛ࡍ࠿ࠋ
㸦㔝⏣㸧 㐌  ᫬㛫࡛ࡍࠋ㸦᳃㸧 ࠶࠶ࠊࡑࢀࣉࣛࢫ࡛᭩ࡅࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦㛗㇂㸧 ≉௵◊✲ဨࡣ  ᫬㛫࡛ࠊࡉࡽ࡟᫬㛫㞠⏝࡛ࡣ࡞ࡃ࡚⿢㔞ປാไࡢᖖ໅໬ࢆࡍࡿ࡜
࠸࠺ࡢࡀὶࢀ࡛ࡍࡼࡡࠋ
㸦஭ཱྀ㸧 ពእ࡜㏻ࡗ࡚࠸ࡲࡍࡡࠋ
㸦㛗㇂㸧 ㏻ࡗ࡚࠸ࡲࡍࡡࠋ
㸦஭ཱྀ㸧 NIBB ࣜࢧ࣮ࢳࣇ࢙࣮ࣟࡣ࠺ࡕࡢ㸯ே࡜ JSPS ࡶฟࡏࡿࡢ࡛ࠊࡑࡕࡽ࡛ࠊ࣏ࢫࢻࢡ
㸰ே࡜ࡶ⛉◊㈝ࢆ௒ᖺࡣྲྀࡗ࡚࠸ࡲࡍࠋ
㸦᳃㸧 ࡛ࡶࠊ᭱㏆࡛ࡍࡼࡡࠋ
㸦஭ཱྀ㸧 ࡑ࠺࡛ࡍࡡࠋ
㸦᳃㸧 ◊✲ᨭ᥼ᐊ࡟⪺࠸࡚ࡳࡓࡽࠊ࣮࢜ࢣ࣮ࡀฟࡓࡢࡀࠋ
㸦஭ཱྀ㸧 ࡛ࡁࡿࡼ࠺࡟࡞ࡗࡓࡢࡀึࡵ࡚ࡔࡗࡓࡢ࡛ࡍࡡࠋ
㸦᳃㸧 ࡛ࡍࡼࡡࠋࡔ࠿ࡽࠊ
ࠕ࠾࠾ࡗࠖ࡜ᛮ࠸ࡲࡋࡓࠋ
㸦㛗㇂㸧 ࡔ࠿ࡽࠊࡐࡦࡑࡢ᪉ࡣ◊✲௦⾲⪅࡜ࡋ࡚ࡢ⊂⮬ᛶࢆᣢࡗ࡚◊✲ࢆࡉࢀ࡚ࠊ౛࠼ࡤ
ㄽᩥࢆฟࡍ࡜ࡁ࡟ࡣࢥࣞࢫ࣏ࣥࢹ࢕ࣥࢢ࣮࢜ࢧ࣮ࡀࡑࡢே࡟࡞ࡗ࡚ࠊ࢔ࢡࣀࣜࢵࢪ࡟ࡣࡑࡢ
ⱝᡭ◊✲࡜࠸࠺ࡼ࠺࡞ࡶࡢࢆ᭩࠿ࢀ࡚ࠊไᗘⓗ࡟ࡁࡕࢇ࡜ฟࡿࡼ࠺࡟࡞ࢀࡤ኱ኚ⣲ᬕࡽࡋ࠸࡛ࡍࡼࡡࠋࡓࡔࠊࡑࡢࢢ࣮ࣝࣉ࡟࡜ࡗ࡚ࡣ஧㔜࡟◊✲㈝ࢆྲྀࡗ࡚࠸ࡿࡢࡔ࡜࠸࠺ࡼ࠺࡞ぢ᪉− 93 −

ࡀ࡞࠸ࡼ࠺࡞ᙧ࡛ࡐࡦ㐠⏝ࡋ࡚࠸ࡓࡔࡁࡓ࠸࡜࠸࠺࠿ࠊࡇࢀࡣ⮬ศࡓࡕ࡟ࡶゝࡗ࡚࠸ࡿࡇ࡜
࡞ࡢ࡛ࡍࡀࠋ㸦すᮧ㸧 Ꮫ᣺ࡢ᪉࡛ࡶࡑࡢࡼ࠺࡟㐍ࡵ࡚࠸ࡿࡢ࡛ࡍ࠿ࡡࠋ
㸦㛗㇂㸧 ࡑ࠺࡛ࡍࡡࠋࡓࡔࠊࡑ࠺࠸࠺ไᗘࡣ࢔࣓ࣜ࢝࡟ࡣ࡞࠸ࡢ࡛ࠊ࢔࣓ࣜ࢝࠿ࡽᖐࡗ࡚
ࡁࡓ PI ࡢேࡣ⤯ᑐ࡟↓⌮࡛ࡣ࡞࠸࠿࡜ឤࡌࡿࢃࡅ࡛ࡍࠋ㸦すᮧ㸧 ࠶࠶ࠊࡑ࠺࡛ࡍ࠿ࠋ
㸦㛗㇂㸧 㞠⏝⪅࡛࠶ࡿඛ⏕ࡢ௙஦࡜ࡣࡲࡓูࡢ௙஦ࢆࡍࡿࡢ࠿ࠊ࣏ࢫࢻࢡ࡛ࡑ࠺࠸࠺ࡇ࡜
ࡣ࠶ࡾᚓ࡞࠸࡜࠸࠺ࠊࡑࢀࡶ୍ࡘࡢ⪃࠼࡛ࡍࡼࡡࠋࡔ࠿ࡽࠊ᪥ᮏࡢࡑࡇࡢ㒊ศࡣࠊ࢟ࣕࣜ࢔
ࣃࢫ࡜࠸࠼࡝ࡶ㠀ᖖ࡟࠶࠸ࡲ࠸࡞ᐃ⩏࡙ࡅ࡟࡞ࡗ࡚࠸ࡿࢃࡅ࡛ࠊࡇࢀࡀࡎࡗ࡜⥆ࡃ࡜ࡣ࡜࡚
ࡶᛮ࠼࡞࠸࡛ࡍࡼࡡࠋ
㸦ᒣᮏ㸧 ᅜ࡞ࡾ JSPS ࡞࡝ࡣࠊࡑ࠺࠸࠺᪉ࡀⱝᡭࢆ࢚ࣥ࢝ࣞࢵࢪࡋ࡚࠸ࡿ࡜࠸࠺ࡩ࠺࡞ุ
᩿ࡀ࠶ࡿ࠿ࡽ࡜࠸࠺ࡇ࡜࡛ࡍࡼࡡࠋ
㸦㛗㇂㸧 ௒ࡣࡑ࠺࠸࠺ࡩ࠺࡟ぢ࡚࠸ࡿࢃࡅ࡛ࡍࡼࡡࠋ㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ
㸦㛗㇂㸧 ࡣ࠸ࠊࡑࡇࡣࡼࡃศ࠿ࡾࡲࡋࡓࠋ㸦すᮧ㸧 ᫬㛫ࡀࡑࢁࡑࢁ᮶࡚࠾ࡾࡲࡍࡀࠊ኱Ꮫ㝔ࡢⱝᡭࡢ◊✲⪅࡜࠸࠺ࡇ࡜࡟㛵ࡋ࡚ࡣࡼࢁࡋ࠸࡛ࡍ࠿ࠋ௚࡟ࡈពぢࡀࡈࡊ࠸ࡲࡏࢇࡼ࠺࡛ࡋࡓࡽࠊḟࡢᑗ᮶ィ⏬࡟ࡘ࠸࡚࡜࠸࠺࡜ࡇ
ࢁ࡟⛣ࡽࡏ࡚࠸ࡓࡔࡁࡲࡍࠋᑠᯘࡉࢇࠊ࠾㢪࠸ࡋࡲࡍࠋ㸰 ᑗ᮶ィ⏬㸦኱つᶍ◊✲ィ⏬ࠊᴫ⟬せồ㸧㸦ᑠᯘ㸧 ㈨ᩱ㸯ࡢ 3 ࡜㈨ᩱ㸱ࡢ 3 ࡀ㛵㐃㈨ᩱ࡛ࡍࠋ⡆༢࡟ࡈㄝ᫂ࡋࡓ࠸࡜ᛮ࠸ࡲ
ࡍࠋ ࡇࢀࡣ࡯࡜ࢇ࡝᪂㡿ᇦࡢ㛤ᣅࡢ࡜ࡇࢁ࡛㏙࡭ࡽࢀࡓࡇ࡜࡞ࡢ࡛ࡍࡀࠊ㈨ᩱ㸱ࡢ 3 ࢆࡈぴࡃࡔࡉ࠸ࠋ୍␒ୖࡀ᪥ᮏᏛ⾡఍㆟ࡢࠕᏛ⾡ࡢ኱ᆺ᪋タィ⏬࣭኱つᶍ◊✲ィ⏬ࠖࡢࢱ࢖ࢺࣝ
࡜ࡋ࡚ࢃࢀࢃࢀࡀ๓ᖺᗘ࡟ᣲࡆࡓࡶࡢ࡛ࡍࡀࠊ
ࠕ⏕≀ࡢ⎔ቃᛂ⟅ᡓ␎ゎ᫂ࡢࡓࡵࡢ኱Ꮫ㐃ᦠ◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡࡢᙧᡂࠖ࡜࠸࠺ࡇ࡜࡛ࠊࢃࢀࢃࢀࡢ◊✲ᡤ࡛ࡣࡑࢀࢆᨭ࠼ࡿ୕ࡘࡢᴫ⟬せồ࡜ࡋ࡚ࠊ୸࠸᳜ᮌ㖊ࡢࡼ࠺࡞࢜ࣞࣥࢪⰍ࡜㯤Ⰽ࡜⥳ࡢᰕࡀ࠶ࡾࡲࡍࠋ

 ㈨ᩱ㸯ࡢ 3 ࡟࠶ࡿࠊࠕ㸯㸧ࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࠖࡀ⥳ࡢ㒊ศ࡟࡞ࡾࡲࡍࠋ
ࡶ࠺୍ࡘࡀࠊ
ࠕ㸰㸧኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ࡛ࠖࠊࡇࢀࡀ࢜ࣞࣥࢪࡢ㒊ศ࡟− 94 −

࡞ࡿࢃࡅ࡛ࡍࠋࡶ࠺୍ࡘᨭ࠼ࡿࡶࡢࡀࠊḟࡢ࣮࣌ࢪࡢࠊඛ࡯࡝࠿ࡽヰ࡟ฟ࡚࠸ࡿࠕ㸱㸧኱Ꮫ㛫㐃ᦠ࡟ࡼࡿ᪂つࣔࢹࣝ⏕≀ࡢ㛤ⓎᣐⅬᙧᡂ࡛ࠖࠊࡇࡇ࡟᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࡢᵓ
᝿ࡀධࡗ࡚࠸ࡿࢃࡅ࡛ࡍࠋࡇࡢ୕ࡘ࡟ࡼࡗ࡚኱ᆺ᪋タィ⏬࣭኱つᶍ◊✲ィ⏬ࡢࣉࣟࢪ࢙ࢡࢺ
ࢆᨭ࠼࡚࠸ࡿ࡜࠸࠺ᵓᅗ࡛ࡍࠋ࠸ࡎࢀࡶᮏᖺᗘࡣ⥅⥆ㄢ㢟࡜ࡋ࡚⏦ㄳࡍࡿணᐃ࡛ࡍࠋ
 ࡑࢀࢆᨭ࠼ࡿୗࡢᅄゅࡢ㒊ศ࡟࠶ࡿࡢࡀࠊ㈨ᩱ㸯ࡢ 3 ࡢࠕ㸲㸧␗ศ㔝⼥ྜ࡟ࡼࡿ⏕≀ࡢ㐺ᛂ⬟ຊࡢ◊✲ࡢ๰ᡂ࡟ྥࡅࡓከඖⓗ⏕≀᝟ሗࡢ⤫ྜゎᯒࢩࢫࢸ࣒ࠖ࡜࠸࠺ࡶࡢ࡛ࠊࡇࡢ
⤫ྜゎᯒࢩࢫࢸ࣒ࡀࠊ⥳ࡢᅄゅࡢ㒊ศ࡟࡞ࡾࡲࡍࠋࡉࡽ࡟ࠊ
ࠕ㸳㸧ྠࢩࢫࢸ࣒⏝㔝እ᪉⢭ᐦ⎔ቃไᚚ⿦⨨ࠖࡶ⥳ࡢᅄゅࡢ㒊ศ࡟࡞ࡿࢃࡅ࡛ࡍࠋࡉࡽ࡟ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࢆᨭ࠼ࡿ
⿵ṇண⟬࡛ධࡗࡓタഛࡶࡇࡇ࡟࠶ࡾࡲࡍࠋ
 ࡇࡢࡼ࠺࡟୕ࡘࡢ⥅⥆ࡢᴫ⟬せồ஦㡯ࡀ࠶ࡿࡢ࡛ࡍࡀࠊ࣏࢖ࣥࢺ࡜ࡋ࡚ࡣࠊ㸯㸧㸰㸧ࠊࡍ࡞ࢃࡕ⎔ቃ㐺ᛂᡓ␎㸦⥳ࡢ㒊ศ㸧࡜ࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦࢜ࣞࣥࢪࡢ㒊ศ㸧ࡀᖹᡂ  ᖺᗘ࡟⤊஢ࡋࡲࡍࡢ࡛ࠊ௒ᖺᗘࡢ⤊ࢃࡾ࡟ࡣ࡝ࡢࡼ࠺࡞ᴫ⟬せồ࡛ࠊ⥅⥆࡟ࡍࡿࡢ࠿ࠊ
ࡑࢀ࡜ࡶࡇࢀࢆࡸࡵ࡚᪂ࡋ࠸ࡢ࡟ࡍࡿࡢ࠿࡜࠸࠺Ỵᐃࢆࡋ࡞ࡅࢀࡤ࠸ࡅ࡞࠸࡜⪃࠼࡚࠾ࡾࡲ
ࡍࠋࡑࡢࡓࡵ࡟㸯ᖺ㛫࠿ࡅ࡚࡝ࡢࡼ࠺࡞ᴫ⟬せồ࡟ࡍࡿ࠿ࠊᇶᮏⓗ࡟ࡣࡑࢀࡒࢀࡢᡤ࡟࠸ࡿ
ඛ⏕᪉ࡢ◊✲ࢆేࡏࡿᙧ࡛᪂ࡋ࠸᪉ྥᛶࢆ᥈ࡿ࣎ࢺ࣒࢔ࢵࣉᆺࡢࣉ࣏࣮ࣟࢨࣝࢆ᭩ࡅࢀࡤ࡜
⪃࠼࡚࠾ࡾࡲࡍࠋࡓࡔࠊ௒ࡣࡑ࠺࠸࠺ヰࡋྜ࠸ࢆጞࡵࡓ࠸࡜࠸࠺࡜ࡇࢁ࡛ࡍࡢ࡛ࠊලయⓗ࡞᱌ࡣ௒ࡢ࡜ࡇࢁࡣ࠶ࡾࡲࡏࢇࠋ
 ࡶ࠺୍ࡘࡢ࣏࢖ࣥࢺ࡜ࡋ࡚ࡣࠊ᪂つࡢ᪉ྥᛶࡣఱࡀ࠶ࡿࡢ࠿࡜࠸࠺ࡇ࡜࡛ࡍࠋ௒ࠊ⪃࠼࡚࠸ࡿࡢࡣ኱Ꮫඹྠ฼⏝ࡢࡓࡵࡢࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࢭࣥࢱ࣮࡛ࡍࠋࡇࢀࡣࡇࡇ࡟ࡣ᭩ࡁ㎸ࢇ࡛࠶ࡾࡲࡏࢇࡀࠊࡇࢀࢆ᪂つࡢᴫ⟬せồ஦㡯࡜ࡋ࡚ୖࡆࡓ࠸࡜ᛮ࠸ࡲࡍࠋࡇࡇ࡟ᩥ❶ࡣ࠶ࡾࡲࡏࢇࡀࠊせⅬࡔࡅ⏦ࡋୖࡆࡲࡍ࡜ࠊඛ࡯࡝࠿ࡽฟ࡚࠸ࡿ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ᡤᒓࡢගᏛ
ゎᯒᐊࠊࡇࢀࡣ኱ᆺࢫ࣌ࢡࢺࣟࢢࣛࣇࡸ DSLM㸦ගࢩ࣮ࢺᆺ㢧ᚤ㙾㸧ࠊࡲࡓ IR-LEGO ࡜࠸࠺ᶵჾ➼ࢆᢅ࠺࡜ࡇࢁ࡛ࡍࡀࠊࡇࢀࢆᨵ⤌ࡋ࡚ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࢭࣥࢱ࣮࡟ࡋࡓ࠸࡜࠸࠺せồ࡛ࡍࠋ ࡇࢀࡣᇶᮏⓗ࡟࡝࠺࠸࠺⪃࠼᪉࠿࡜࠸࠸ࡲࡍ࡜ࠊ኱Ꮫ➼ࡢ᪋タ࡟ᑟධࡍࡿࡇ࡜ࡀ㞴ࡋ࠸ࡼ࠺࡞ඛ➃ࡢගᏛᶵჾࢆᩚഛࡋ࡚ࠊࡉࡽ࡟኱Ꮫ➼ࡢ◊✲⪅ࡢ◊✲ࢆ᥎㐍ࡍࡿࡓࡵ࡟ᅜෆࡢࢿࢵ
ࢺ࣮࣡ࢡࢆᵓ⠏ࡋࡓ࠸࡜࠸࠺ࡇ࡜࡛ࡍࠋࡶ࠺ᑡࡋᖹࡓࡃゝ࠸ࡲࡍ࡜ࠊ௒⌧ᅾྛ኱Ꮫ࡟ࡣࠊྡ
ྂᒇ኱Ꮫ࡟ࡶ࠶ࡾࡲࡍࡀࠊඛ➃ⓗ࡞ගᏛᶵჾࢆ㞟ࡵ࡚࠸ࡿࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࢭࣥࢱ࣮ࡢࡼ
࠺࡞ࡶࡢࡀᗄࡘ࠿࠶ࡾࡲࡍࠋࡑࢀ௨እ࡟ࡶ OIST ࡸ㜰኱࡞࡝ࡶ࠶ࡿ࡜ᛮ࠸ࡲࡍࡀࠊ࡛ࡣࠊ୍
య࡝ࡇ࡟࡝࠺࠸࠺ࡶࡢࡀ࠶ࡗ࡚ࠊ࡝࠺࠸࠺౑࠸᪉ࡀࡉࢀ࡚ࠊඹྠ◊✲ࡣࡑࡇ࡟⾜ࡅࡤ࡛ࡁࡿ
ࡢ࠿࡜࠸࠺ࡇ࡜ࡣࠊ࡞࠿࡞࠿ศ࠿ࡾ࡟ࡃ࠸≧ἣ࡟࠶ࡾࡲࡍࠋࡑ࠺࠸࠺ព࿡࡛ࠊඛ᭶ࢃࢀࢃࢀ
ࡣ࢖࣓࣮ࢪࣥࢢ࡟㛵ࡋ࡚඲ᅜ኱Ꮫ➼ࡢࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ㐃ᦠయไࡢ௒ᚋࡢ࠶ࡾ᪉ࢆ⪃࠼ࡿ఍࡜࠸࠺ࡶࡢࢆ㛤ദࡋࠊࡲࡔỴࡲࡗ࡚࠾ࡾࡲࡏࢇࡀࠊࢿࢵࢺ࣮࣡ࢡࢆసࡿࡼ࠺࡞ᇶ┙࡙ࡃࡾࢆࡋ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠾ࡾࡲࡍࠋࡑࡢᵓ᝿ࡢᇶ࡟࡞ࡿࡢࡀࠊ௒ゝࡗࡓ᪂つࡢ኱Ꮫඹྠ฼⏝− 95 −

ࡢࡓࡵࡢࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࢭࣥࢱ࣮࡛ࡍࠋ
 せⅬࡣࡑࢀࡄࡽ࠸࡞ࡢ࡛ࡍࡀࠊࡼࢁࡋ࠸࡛ࡋࡻ࠺࠿ࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋࡇࡢⅬ࡟㛵ࡋ࡚ࡶ࢔ࣥࢣ࣮ࢺࡢ୰࡛ࡈពぢࢆఛࡗ࡚࠾ࡾࡲࡍࠋࡑࡢ୰࡛ࡣ๓࡟ሷぢඛ⏕ࡀ࠾ࡗࡋࡷࡽࢀ࡚࠸ࡓࡼ࠺࡟ࠊ᪂つࣔࢹࣝ⏕≀ࡢ㛤
Ⓨ࡜࠸࠺࡜ࡇࢁࡀ㠀ᖖ࡟㔜せࡔ࡜࠸࠺ࡇ࡜ࢆ඲࡚ࡢ㸲ྡࡢඛ⏕ࡀᣦ᦬ࡉࢀ࡚࠾ࡾࡲࡍࠋᐇ㝿࡟ࢭࣥࢱ࣮ࡀ࡛ࡁ࡚௒ᖺ࠿ࡽ㐠⏝ࢆጞࡵ࡚࠸ࡃ࡜࠸࠺ࡇ࡜࡟࡞ࡾࡲࡍࡅࢀ࡝ࡶࠊ⚾࡝ࡶࡶࡑࡢ㔜せᛶࢆࡋࡗ࠿ࡾᢕᥱࡋ࡚㐍ࡵ࡚࠸ࡁࡓ࠸࡜ᛮࡗ࡚࠾ࡾࡲࡍࠋࡇࡢⅬ࡟㛵ࡋ࡚ࡈពぢࡀࡈࡊ࠸ࡲࡋࡓࡽ࠾㢪࠸ࡋࡲࡍࠋ
㸦᳃㸧 ࠺ࡕࡢ ITbM ࡣྜᡂ໬Ꮫࡢఀ୹೺୍㑻ࡉࢇࡀᣐⅬ㛗࡛ࠊᮾᒣဴஓࡉࢇࡀ๪ᣐⅬ㛗࡛ࡍࡀࠊࡇࡇ࡟ࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢࢭࣥࢱ࣮࡜࠸࠺ࡶࡢࡀ࠶ࡿࡢ࡛ࡍࡡࠋࡇࢀࡣࡪࡗࡕࡷࡅࡓ
ヰࢆゝ࠺࡜ࠊ࢝ࢫࢱ࣐࢖ࢬࡉࢀ࡚࠸࡞࠸࡜౑࠸࡙ࡽ࠸࡜ᛮ࠺ࡢ࡛ࡍࠋ౛࠼ࡤ⥺⹸ࠊ౛࠼ࡤࢮ
ࣈࣛࣇ࢕ࢵࢩࣗࠊ౛࠼ࡤఱ࡜࠿ࡢ㠀ࣔࢹࣝື≀࡛ࡶ࠸࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀ࡟࠸ࢁ࠸ࢁ࡞
࢔ࢱࢵࢳ࣓ࣥࢺࢆ௜ࡅ࡚ࠊᮏᙜࡣ࢝ࢫࢱ࣐࢖ࢬࡋ࡚ࡑࢀࢆ౑࠸ࡓ࠸ࠋඹྠ࡛࠶ࡿሙྜࠊ஧ග
Ꮚ㢧ᚤ㙾ࡣ  ୓ࠊ㸯൨෇ࡍࡿࡶࡢࡀ࠶ࡾࡲࡍࡼࡡࠋࡔ࠿ࡽࠊ࠶ࡿ✀ࡢࢪ࣐ࣞࣥ࡜࠸࠺࠿ࠊ
⚾ࡣ᪩ࠎ࡜⇿ᙎពぢࡳࡓ࠸࡞ࡇ࡜ࢆゝࡗ࡚࠸ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀࡀ࠶ࡿ࡜ゝࡗ࡚ࠊᮏᙜ
ࡢព࿡࡛ࡑࢀࡀඹྠ฼⏝࡜ࡋ࡚౑࠼ࡿ࠿࡜࠸࠺࡜ࠊ㠀ᖖ࡟㞴ࡋ࠸ၥ㢟࡞ࡢ࡛ࡍࠋ
 ௒ࡣ኱Ꮫ࡛ࡶࠊWPI ࡛ࡣ࡞࠸࡛ࡍࡀࠊࡑ࠺ࡸࡗ࡚ࢭࣥࢱ࣮໬ࠊᶵᵓ໬ࡋ࡚ࠊᴫ⟬࡛࠾㔠ࡀ
㏻ࡗ࡚࠸ࡿ࡜ࡇࢁࡀ࠶ࡾࡲࡍࠋ⚾ࡓࡕࡶࡑࢀࢆࡸࢁ࠺࡜ࡋ࡚࠸ࡿࡢ࡛ࡍࡀࠊࡑ࠺࡞ࡗ࡚࠾㔠ࡀ௜࠸࡚ࡃࡿ࡜ࠊ኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ࡢᇶ⏕◊ࡢ❧ࡕ఩⨨ࢆࡶࡗ࡜ࣘࢽ࣮ࢡ࡟ฟࡋ࡚࠸
࠿࡞࠸࡜ࠊࠕఱ࡞ࡢ㸽ࠖ࡜ゝࢃࢀ࡚ࡋࡲ࠺ࡢ࠿࡞࡜࠸࠺༴᝹ࡀ࠶ࡾࡲࡍࠋࡔ࠿ࡽࠊ࠾ࡗࡋࡷࡗ
࡚࠸ࡓ㠀ࣔࢹࣝ⏕≀࡜࠿ࠊࡑ࠺࠸࠺ࡶࡢ࡟ࣇࣞ࢟ࢩࣈࣝ࡟౑࠼ࡿࡶࡢࡸࠊ
ᐇࡣࡑ࠺ࡔࡅࢀ࡝ࠊ
ࡸࡣࡾಶࠎࡢඹྠ◊✲ࡀẕయ࡟࡞ࡗ࡚࠸ࡿࠋᐇ㝿࡟ࡣࠕඹྠࠊඹྠࠖ࡜ゝࡗ࡚࠸ࡿࡅࢀ࡝ࡶࠊ
ಶࠎࡢඹྠ◊✲ࢆࡸࡗ࡚࠸ࡃ࡜࠸࠺ࡢࡀ୍ࡘࡢ࣮࣋ࢫ࡛࠶ࡿ࡜࠸࠺࠿ࠊࡑࢀࢆ㠀ᖖ࡟኱஦࡟
ࡉࢀࡿࠋࡓࡔࠊࡰࢇࡸࡾඹྠ࡜࡞ࡿ࡜ࠊ࢔ࢡࢭࢫࡀ㠀ᖖ࡟ࡋ࡟ࡃ࠸࡜࠸࠺ࡢࡀᐇࡣ࠶ࡿࡢ࡛
ࡍࡼࡡࠋࡑࡇࡢᆅᇦⓗࣂࣜ࢔ࢆྲྀࡗ࡚࠸ࡃ࡜࠸࠺࠿ࠋ
㸦ᑠᯘ㸧 ࠾ࡗࡋࡷࡿ࡜࠾ࡾ࡛ࠊࡸࡣࡾ◊✲ࡣࠊ࡝ࢇ࡞◊✲⪅ࡀࡸࡗ࡚࠸ࡿࡢ࠿ࠋࡑࡢ◊✲⪅࡜୍⥴࡟ࡸࡗ࡚ࠊࡑࡢᶵᲔࢆ౑࠸ࡓ࠸࠿ࡀ኱ษ࡛ࡍࠋ⏕≀ᶵ⬟᝟ሗศᯒᐊ୍࡛ࡘᡂຌࡢ᪉
ྥ࡟ᑟ࠿ࢀࡓ⌮⏤ࡣࠊࡑࡇࡢ㔜ಙࡉࢇࡀඹ⏕ࢆ◊✲ࡋ࡚࠸࡚ࠊࡑࢀ㛵㐃ࡢேࡀከࡃ࡚ࠊࡑࡇ
࡛ࡢᡂᯝࡀฟ࡚࠸ࡿ࡜࠸࠺ࡇ࡜࡛ࡍࠋ ගᏛゎᯒᐊ࡟㛵ࡋ࡚ࡣࠊட஭ࡉࢇ⮬㌟ࡣࠊIR-LEGO ࡣࡈᏑࡌࡔ࡜ᛮ࠸ࡲࡍࡀࠊ㉥እ⥺ࢆᙜ࡚࡚ࣄ࣮ࢺࢩࣙࢵࢡࢆ⣽⬊༢఩࡛୚࠼࡚ࠊ㑇ఏᏊࢆⓎ⌧ࡉࡏࡿࢩࢫࢸ࣒࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀ
ࡀ࠶ࡗ࡚ࠊࡑࡢඹྠ◊✲୍࡛ࡘࡢᇶ┙ࢆ⠏࠸ࡓ࡜࠸࠺ࡇ࡜࡛ࡍࠋࡔ࠿ࡽࠊࡑࡇࢆ୰ᚰ࡟ᗈࡆ
࡚࠸ࡃࢃࡅ࡛ࡍࠋࡅࢀ࡝ࡶࠊࡇࡇ࡟⾜ࡅࡤࠊ࡝࠺࠸࠺ື≀࡟ᑐࡋ࡚ IR-LEGO ࢆᙜ࡚࡚࡛ࡁࡿ

− 96 −

ࡢ࠿ࠋࡑࡢ᝟ሗࡀࡸࡣࡾ࡞࠸ࡢ࡛ࡍࠋࡔ࠿ࡽࠊࡑ࠺࠸࠺ព࿡࡛ࡣࢿࢵࢺ࣮࣡ࢡࢆసࡽ࡞࠸࡜
௚ࡢ኱Ꮫࡢேࡣ࢔ࢡࢭࢫࡋ࡙ࡽ࠸࡜࠸࠺ࡢ࡛ࠊࢿࢵࢺ࣮࣡ࢡ࡜࠸࠺ࡇ࡜ࢆ୍ࡘࡣ⪃࠼࡚࠸ࡲࡍࠋ ࡶ࠺୍ࡘࡣࠊ☜࠿࡟㢧ᚤ㙾ࡀ୍ࡘࡔࡅ࠶ࡗ࡚ࡑࢀࢆඹྠ࡛౑ࡗ࡚࡜࠸࠺ࡢࡣ㞴ࡋ࠸࡛ࡍࠋ
ࡔ࠿ࡽࠊࢃࢀࢃࢀࡢ࡜ࡇࢁ࡛ࡣࠊ↓㥏࠿ࡶࡋࢀࡲࡏࢇࡀࠊ౛࠼ࡤ஧ගᏊ࡛ࡣಽ❧࡜ṇ❧ࡀ࠶ࡗ࡚ࠊࡑࢀࡒࢀࡢ౑࠸᪉ࡀ࡛ࡁࡿࡼ࠺࡟ࠊࡉࡽ࡟ࠊሙᡤࡀ㞳ࢀ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡀ࠶ࡾࡲࡍ
ࡀࠊࡇࡕࡽࡢ᫂኱ᑎ࡜ྥࡇ࠺ࡢᒣᡭ࡟ศ࠿ࢀ࡚ࠊ㐪࠺ࡼ࠺࡞౑࠸᪉ࡀ࡛ࡁࡿࠋ࠶࡜ࡣ DSLMࠊගࢩ࣮ࢺ㢧ᚤ㙾࡛ࡶࠊࡇࢀࡣ㞴ࡋ࠸ࡢ࡛ࡍࡀࠊẖᅇヨᩱࢆ࡝࠺⨨࠸࡚࡝ࡢࡼ࠺࡟ほᐹࡍࡿ࠿ࠊ
Ỵࡵࡿࡢ࡟᫬㛫ࡀ࠿࠿ࡿࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑࢀࢆ᳨ウࡋࡓᚋ࡛ᐇ㝿ࡢほᐹࢆ⾜࠺ࢃࡅ࡛ࡍࠋ
 ࡔ࠿ࡽࠊࡑࡢࡼ࠺࡟࢝ࢫࢱ࣐࢖ࢬࡍࡿࡇ࡜࡛ࡍࠋ኱ࡁ࡞ᶵᲔࡀᚲせ࡜࠿࠸࠺ࡇ࡜ࡔ࡜㞴ࡋ࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡕࡻࡗ࡜ࡋࡓ࢝ࢫࢱ࣐࢖ࢬ࡛ࡁࡿ⠊ᅖࡣ♧ࡏࡿࡢ࠿࡞࡜ࡣ⪃࠼࡚࠾ࡾࡲ
ࡍࠋࡓࡔࠊ㞴ࡋ࠸࡜ࡇࢁࡣ࡝ࡇ࠿࡜ඹྠ࡛࡜࠸࠺ࡇ࡜ࡣ࠶ࡾᚓࡿ࡜ᛮ࠸ࡲࡍࡀࠊࡑࡢ᝟ሗࡉ
࠼ᾐ㏱ࡋ࡚࠸࡞࠸࡜࠸࠺≧ἣࡔ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊከศࡑ࠺࠸࠺ពぢ஺᥮ࡶྵࡵ࡚ࢿࢵࢺ࣮࣡
ࢡࢆసࡿࡢࡀ㔜せࡔ࡜൅ࡣᛮ࠸ࡲࡍࡅࢀ࡝ࡶࠋ
㸦᳃㸧 ࡑࡇ࡛ᇶ⏕◊ࡀࢭࣥࢱ࣮࡟࡞ࡗ࡚ࠊ࠸ࢁ࠸ࢁ┦ㄯࡍࡿ࡜ࠊࡑࢀ࡟㛵ࡋ࡚ࡣࢫ࣌ࢩࣕ
ࣝ࡞ඛ⏕ࡀࡇࡇ࡟࠸࡚ࠊඹྠ◊✲ࡋ࡞ࡀࡽࠊࡑࡢᶵᲔࡶ౑ࢃࡏ࡚ࡶࡽ࠺࡜࠿ࠊࡑ࠺࠸࠺ࡇ࡜
ࡀ࡛ࡁࡿ࡜࠸࠺ࡇ࡜࡛ࡍࡡࠋ
㸦ᑠᯘ㸧 ࡑࢀࡀ⌮᝿ࡔ࡜ᛮ࠸ࡲࡍࠋ
㸦᳃㸧 ⌮᝿࡛ࡍࡡࠋ
㸦ᑠᯘ㸧 ࡓࡔࠊࢿࢵࢺ࣮࣡ࢡࡢ࡝ࡇࡀ୰ᚰࡔ࡜ゝ࠸ฟࡍ࡜ࠊ⚾ࡢ࡜ࡇࢁࡀ୰ᚰࡔ࡜࠸࠺࡜
ࡇࢁࡀᗄࡘ࠿࠶ࡿ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊࡑ࠺࠸࠺ព࿡࡛ࡣࠊࢿࢵࢺ࣮࣡ࢡ࡙ࡃࡾࡢ࠾ᡭఏ࠸ࢆࡍ
ࡿࠋࡑࡢ୰࡛ಶࠎࡢ⊂⮬ᛶࢆฟࡋ࡚࠸ࡃᴫ⟬せồ࡜ࡈ⌮ゎ࠸ࡓࡔࡅࢀࡤ࡜ᛮ࠸ࡲࡍࠋ
㸦᳃㸧 ࠶࡜ࡣᮏᙜ࡟ࢭࣥࢱ࣮࡜࡞ࡗ࡚ࠊ࠸ࢁ࠸ࢁ࡞ࢽ࣮ࢬ࡟ᛂ࠼ࡽࢀࡿ࡜࡞ࡿ࡜ࠊᢏ⾡⫋ဨࡀ㔜せ࡛ࡍࡼࡡࠋ࡛᫇ゝ࠺࡜ࡇࢁࡢࠊ࡜ゝࡗࡓࡽኻ♩࡞ࡢ࡛ࡍࡀࠊ࢚ࣥࢪࢽ࢔࡜࠸࠺ࡢ࡛
ࡋࡻ࠺࠿ࠊ࠿࡞ࡾ㧗ᗘ࡞࠸ࢁ࠸ࢁ࡞ᢏ⾡ࡶ▱㆑ࡶ࠶ࡿࡼ࠺࡞᪉ࡓࡕ࡛ࡍࠋࡑ࠺࠸࠺ேࡢ⥅⥆ⓗ࡞㞠⏝ࡀ⤯ᑐ࡟኱஦ࡔ࡜ᛮ࠺ࡢ࡛ࡍࡀࠊࡑࡢ㎶ࡢ࠾㔠ࡣ࡝࠺࡞ࡢ࡛ࡍ࠿ࠋ㸦ᑠᯘ㸧 ࠾㔠࡜࠸࠸ࡲࡍ࠿ࠊᖖ໅⫋ဨ࡜ࡋ࡚ᢏ⾡⫋ဨ࡜࠸࠺ไᗘࡀࢃࢀࢃࢀࡣ࠶ࡾࡲࡋ࡚ࠊ
ศᯒࡢ᪉࡛ࡶࡑ࠺࡛ࡍࡅࢀ࡝ࡶࠊࢩ࣮ࢣࣥࢧ࣮ࡢࣀ࢘ࣁ࢘ࢆ⵳✚ࡍࡿࠋ࠶࡜ࡣࠊගᏛゎᯒᐊࡢ኱ᆺࢫ࣌ࢡࢺࣟࢢࣛࣇ࡞࡝ࠊࡶࡢࡍࡈࡃ≉Ṧ࡞ᶵᲔࠊDSLMࠊIR-LEGO ࡶࡑ࠺࡞ࡢ࡛ࡍࡀࠊ
ேᩘࡣࡑࢇ࡞࡟ከࡃࡣ࡞࠸ࡢ࡛ࡍࡅࢀ࡝ࡶࠊࡑ࠺࠸࠺᪉ࡢᴗົ࡜ࡋ࡚ࣀ࢘ࣁ࢘ࢆᜏᖖⓗ࡟⵳✚ࡍࡿ࡜࠸࠺ࡇ࡜ࡣྍ⬟ࡔ࡜ᛮ࠸ࡲࡍࠋࡓࡔࠊ௒ࠊேᩘ࡜ࡋ࡚ࡣ༑ศࡔ࡜ࡣᛮࡗ࡚ࡣ࠾ࡾࡲ
ࡏࢇࠋ− 97 −

㸦᳃㸧 ࠺ࡕࡶࡑ࠺࠸࠺ࡶࡢࡀ࠶ࡿࡢ࡛ࡍࡀࠊࡍࡈࡃ㧗ᗘ࡞ᢏ⾡ࢆᣢࡗ࡚࠸ࡿ᪉ࡀࠊୡ௦஺
௦ࡢ࡜ࡁ࡟᪂ࡋ࠸᪉࡟࡞ࡗ࡚࡬࡞ࡕࡻࡇ࡟࡞ࡿࡢ࡛ࡍࠋࡇࡢᢏ⾡ࡢ⥅ᢎࡀ࠺ࡕࡢ኱Ꮫ࡛ࡶࡍ
ࡈࡃၥ㢟࡟࡞ࡗ࡚࠸࡚ࠊࡑࡢ㎶ࡶᙜ↛࠾⪃࠼ࡔ࡜ᛮ࠺ࡢ࡛ࡍࡀࠋ
㸦ᑠᯘ㸧 ࡑ࠺࡛ࡍࡡࠋࡑࢀࡣࡍࡈࡃ㞴ࡋ࠸ၥ㢟࡛ࡍࠋࡓࡔࠊḟࡢୡ௦ࠊ౛࠼ࡤ㔜ಙࡉࢇࡀ࠸࡚ࠊࡑࡢḟࢆᢸ࠺ேࠊࡶࡕࢁࢇ࠸ࢁ࠸ࢁ࡞ࣀ࢘ࣁ࢘ࡣᢏ⾡⫋ဨࡀ⥅ᢎ࠸ࡓࡋࡲࡍࠋࡓࡔࠊ
ᐇ㝿࡟◊✲ࢆ࣮࢜࢞ࢼ࢖ࢬࡍࡿࠊඹྠ◊✲ࢆ࣮࢜࢞ࢼ࢖ࢬࡍࡿࡼ࠺࡞ḟࡢୡ௦ࢆసࡿ࡜࠸࠺
ࡇ࡜ࡀࡸࡣࡾㄢ㢟ࡔ࡜ᛮ࠸ࡲࡍࠋ ࠶࡜ࡣࠊᢏ⾡⫋ဨ࡟ࡋ࡚ࡶᖺ㱋ࡣୖࡀࡗ࡚࠸ࡁࡲࡍࡢ࡛ࠊࡑ࠺ࡍࡿ࡜᪂ࡋ࠸ᢏ⾡࡟ᑐᛂ࡛ࡁࡿ࠿࡝࠺࠿ࠋ㏫࡟ࡑ࠺࠸࠺ၥ㢟ࡶฟ࡚ࡃࡿ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊࡑࡇࡶၥ㢟Ⅼ࡜ࡋ࡚ᡃࠎࡣᣢ
ࡗ࡚࠾ࡾࡲࡍࠋ࡝࠺ࡋࡓࡽ࠸࠸ࡢ࠿ࡣ㞴ࡋ࠸ၥ㢟ࡔ࡜ᛮ࠸ࡲࡍࡀࠊ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 ᇶ⏕◊ࡔࡅ࡛㠀ᖖ࡟ࣘࢽ࣮ࢡ࡞௚࡟࡞࠸ࡶࡢࢆᣢࡘ࡜࠸࠺ࡼ࠺࡞ࢭࢵࢺ࢔ࢵࣉࡣ
㞴ࡋ࠸ࡢ࡛ࠊࡸࡣࡾ࡝࠺࠸࠺ࢧ࣮ࣅࢫࡀ࡛ࡁࡿ࠿࡜࠸࠺ࢯࣇࢺࡢ㠃࡛ᑐᛂࡋ࡚࠸࠿࡞࠸࡜࠸
ࡅ࡞࠸࠿࡜ᛮࡗ࡚࠸ࡿࡢ࡛ࡍࠋ࡛ࡍ࠿ࡽࠊࡑ࠺࠸࠺ព࿡࡛ࡣࠊ௒ࡣ㔜ಙࡉࢇࡀ㠀ᖖ࡟㡹ᙇࡗ࡚ࡃࢀ࡚࠸ࡲࡍࡀࠊ౛࠼ࡤᙼࡀ࠸࡞ࡃ࡞ࡗࡓࡽ࡝࠺࡞ࡿࡢࡔ࡜ゝࢃࢀࡿ࡜㠀ᖖ࡟ᅔࡿ࡜࠸࠺
≧ἣࡀ࠶ࡾࡲࡍࠋ࠶ࡿព࿡ࠊ㠀ᖖ࡟୙Ᏻᐃ࡞≧ἣ࡛ࡍࠋ㸱 ◊✲ᐊᙉ໬ᡓ␎ᐊࡢ᪂タ㸦すᮧ㸧 ᭱ᚋ࡟୍ࡘṧࡗ࡚࠸ࡿ◊✲ຊᙉ໬ᡓ␎ᐊࡢ᪂タ㸦㈨ᩱ㸯3㸧࡟㛵ࡋ࡚ࡣࠊ◊✲ຊᙉ໬᥎㐍஦ᴗࡀጞࡲࡾࠊᐇ㝿࡟௒ᖺᗘ࠿ࡽᮏ᱁ⓗ࡟◊✲ຊᙉ໬ᡓ␎ᐊࡀືࡁฟࡋࡲࡍࠋ
ࡑࢀ࡟㛵㐃ࡋ࡚⊂❧ዪᛶ◊✲⪅ࠊ෸ᩍᤵࢆເ㞟ࡋ࡚ࠊ」ᩘࡢ㐠Ⴀጤဨࡢ᪉ࠎ࡟ࡑࡢ㑅⪃ጤဨࢆ࠾㢪࠸ࡋ࡚࠾ࡾࡲࡋ࡚ࠊࡑࢀࢆ㐍ࡵ࡚࠸ࡿ࡜࠸࠺ࡼ࠺࡞≧ἣ࡛ࡍࠋࡑࢀࡔࡅ࡛ࡍࡢ࡛ࠊࡲ
ࡓ᮶ᖺᗘ௨㝆ࠊࡇ࠺࠸࠺ᙧ࡛࠸ࢁ࠸ࢁ࡞᪉ྥࢆࡈ㆟ㄽ࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜࡟࡞ࡿ࡜ᛮ࠸ࡲࡍࠋ
 ௨ୖ࡛ࠊ
௒᪥⏝ពࡋࡓⅬ࡟㛵ࡋ࡚ࡣ⤊ࢃࡾࡲࡍࡀࠊ
ఱ࠿ゝ࠸ṧࡋࡓࡇ࡜ࡀࡈࡊ࠸ࡲࡋࡓࡽࠋ
㸦Ⲩᮌ㸧 ௒ᅇࡢ㈨ᩱࢆㄞࡲࡏ࡚࠸ࡓࡔ࠸࡚ࠊ୍ࡘࡕࡻࡗ࡜୙ᛮ㆟࡟ឤࡌࡿࡢࡣࠊᒸᓮࡢ୰
࡛ࡢඹྠ◊✲ࡸࠊ࠾஫࠸࡟࡝࠺࠸࠺ࡇ࡜ࢆࡸࡗ࡚࠸ࡿࡢ࠿࡜࠸࠺ࡇ࡜ࡀぢ࠼࡞࠿ࡗࡓࡢ࡛ࡍࠋ㸦すᮧ㸧 ᒸᓮࡢ㸱◊✲ᡤࡢ୰࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 ࡑ࠺࡛ࡍࠋ㸦すᮧ㸧 ࡑࢀࡣ⤫ྜࣂ࢖࢜࡟౛ࡀ࠶ࡿ࡜ᛮ࠸ࡲࡍࠋ⤫ྜࣂ࢖࢜ࡢ࢜ࣜ࢜ࣥࣉࣟࢪ࢙ࢡࢺࢆ
ᑡࡋ࠾ヰࡋ࠸ࡓࡔࡅࡲࡍ࠿ࠋ㸦ᑠᯘ㸧 ௚ࡢ◊✲ᡤ࡜ࡢඹྠ◊✲ࡣ࡞࠿࡞࠿ᐇ㝿࡟ࡣ㐍ࢇ࡛ࡣ࠸࡞࠸࡜࠸࠺ࡇ࡜࡛ࡍࠋ
௒ࠊ− 98 −

ヰ࡟ฟࡓ࢜ࣜ࢜ࣥࣉࣟࢪ࢙ࢡࢺࡣࠊ⤫ྜࣂ࢖࢜࡟㸱◊✲ᡤ࠿ࡽேࢆฟࡋྜࡗ࡚ࠊ㸱◊✲ᡤࡢ◊✲ࢆ࣐࣮ࢪࡉࡏࡿࡼ࠺࡞◊✲ࠊࡑࢀࡶ᪂ࡋ࠸᪉ྥ࡟ྥ࠿ࡗ࡚ࡢᇶ┙ࢆసࡗ࡚ࠊࡑࢀࢆ㐍ࡵ࡚࠸ࡃࡼ࠺࡞ࡶࡢ࡛ࡍࠋ ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮ࡣࠊ࠿ࢀࡇࢀ  ᖺࡄࡽ࠸๓࡟ฟ᮶ୖࡀࡗࡓࡶࡢ࡛ࡍࡀࠊཤ
ᖺ࡛ࡋࡓ࠿ࠊᴫ⟬せồ࡛᪂ࡋ࠸ࡶࡢࢆྲྀࡾࡲࡋ࡚ࠊࡑࢀࡀᡃࠎࡀ࿧ࢇ࡛࠸ࡿ࢜ࣜ࢜ࣥࣉࣟࢪ
࢙ࢡࢺ࡛ࡍࠋࡑࢀࡣ௒ࡲ࡛ࡢ⤫ྜࣂ࢖࢜࡟࠸ࡿேࡓࡕࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊࡶ࠺ࡕࡻࡗ࡜ᗈࡃྛ
◊✲ᡤࡢ᪉ࡢࣉࣟࢪ࢙ࢡࢺࡶྵࡵ࡚ඹྠ◊✲ࠊ␗ศ㔝⼥ྜࢆ┠ᣦࡋ࡚ࡸࡿࣉࣟࢪ࢙ࢡࢺ࡜࠸
࠺ࡇ࡜࡛ጞࡵ࡚࠾ࡾࡲࡍࡀࠊࡲࡔᐇ㝿࡟ࡣඹྠ◊✲ࡣ࡞࠿࡞࠿ࡉࢀ࡚࠸࡞࠸࡜ࡇࢁࡔ࡜ᛮ࠸
ࡲࡍࠋ ࡑࡢࣉࣟࢪ࢙ࢡࢺࡢ୍ࡘࡣ㔝⏣ඛ⏕ࡀࡉࢀ࡚࠸ࡲࡍࡀࠊఱ࠿࠶ࡾࡲࡍ࡛ࡋࡻ࠺࠿ࠋ
㸦㔝⏣㸧 ⤫ྜࣂ࢖࢜ࡢຓࡗே࡟ྛ◊✲ᡤ࠿ࡽධࢀ࡜࠸࠺ࡼ࠺࡞㊃᪨ࡶ࠶ࡗ࡚ࠊබເࡉࢀࡓ
ࡢ࡛ࠊ⚾ࡀᡭࢆᣲࡆ࡚ࡳࡓ࡜࠸࠺⤒⦋࡛ࡍࠋࡑࢀ࡜ࡣู࡟ᶵᵓᮏ㒊ࡀ୺ദࡋ࡚࠸ࡿศ㔝㛫㐃ᦠ࡜࠸࠺ࡶࡢࡀ࠶ࡾࡲࡋ࡚ࠊ㸱ᖺ࡯࡝๓࠿ࡽⱝᡭ◊✲⪅࡟ᑐࡋ࡚ࠊ」ᩘࡢ◊✲ᡤ࡟ᒓࡍࡿࢢ
࣮ࣝࣉ࡛ࡶࡗ࡚ᶵᵓᮏ㒊࡟ᥦ᱌ࡍࡿ࡜ࠊᖺ  ୓෇ࡲ࡛࡜࠸࠺ࡶࡢࡀື࠸࡚࠸ࡲࡍࠋࡑࡇ࡛
ࡣࠊᇶ⏕◊ࠊ⏕⌮◊ࠊศᏊ◊ࡢⱝᡭࡀ⤌ࢇ࡛ᛂເࡍࡿ࡜࠸࠺ࡇ࡜ࡀጞࡲࡗ࡚࠾ࡾࡲࡍࠋ
㸦ᑠᯘ㸧 ௒ࡢศ㔝㛫㐃ᦠࡢ୰࡛ࠊ≉➹ࡍ࡭ࡁ୍ࡘࡣࠊඛ࡯࡝ᑡࡋฟࡲࡋࡓࡅࢀ࡝ࡶኳᩥྎ
࡜ᇶ⏕◊࡜ࡢ㐃ᦠࡢⱝᡭࡢࣉࣟࢪ࢙ࢡࢺ࡜ࡋ࡚⿵ൾගᏛࢆ౑ࡗࡓࠊᖹࡓࡃゝ࠺࡜ࡁࢀ࠸࡟ぢ࠼ࡿ㢧ᚤ㙾࡛ࡍࠋ⣽⬊ࡢ୰࡟ᾮ⬊࡞࡝ࡀ࠶ࡿ࡜ගࡀᒅᢡࡋ࡚ዟࡢࡶࡢࡀぢ࡟ࡃࡃ࡞ࡾࡲࡍࠋ
ࡑࢀࢆ⿵ൾගᏛ࡛ぢࡿࡢ࡛ࡍࠋኳᩥྎ࡛ᫍࡀ▐ࡃࡢࡣ኱Ẽࡢᦂࡽࡂࡀ࠶ࡿࡓࡵ࡛ࠊࡑࢀࢆ⿵
ൾࡍࡿࡓࡵࡢ㙾ࢆసࡗ࡚ぢࡿࢃࡅ࡛ࡍࠋྠࡌࡶࡢࢆࡇࡇ࡛ᛂ⏝ࡋ࡚ࠊ⣽⬊ࢆ࠺ࡲࡃぢࡿ࡜࠸࠺ࡇ࡜ࡣᡂຌࡋࡘࡘ࠶ࡿ୍ࡘࡢᡂᯝࡔ࡜ᛮ࠸ࡲࡍࠋࡑ࠺࠸࠺ࡶࡢࡀඛ㝕࡜࡞ࡗ࡚ࠊᚋ࡟⥆ࡃ㐃ᦠࡢ◊✲ࠊ⼥ྜࡢ◊✲ࡀฟ࡚ࡃࢀࡤ࡜ࡣᛮ࠸ࡲࡍࡀࠋ
㸦Ⲩᮌ㸧 ⏦ࡋୖࡆࡓࡢࡣࠊࡇࡇ࡟୕ࡘ◊✲ᡤࡀ࠶ࡗ࡚ࠊ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮ࡶ
࠶ࡿࡢ࡟ࠊࡑࢀࡀ඲↛ぢ࠼࡟ࡃ࠸ࡢ࡛ࠊఱ࠿࠶ࡗࡓࡽࠊࡑ࠺࠸࠺ࡶࡢࡀぢ࠼ࡓ᪉ࡀ࠸࠸ࡢ࡛
ࡣ࡞࠸࠿࡜࠸࠺ࡇ࡜࡞ࡢ࡛ࡍࠋ
㸦㛗㇂㸧 ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ࡞࡝ࡣศᏊ◊࡜୍⥴࡟ࡸࡿ࡜ࡋ࡚ᩥ⛉┬࡟ᴫ⟬ࢆฟࡍࡢ࡛࠶
ࢀࡤ࡝࠺࡛ࡋࡻ࠺࠿࡜ゝࡗࡓࡽࠊ⤌⧊ᨵ⦅࡟ࡶࡘ࡞ࡀࡾ࠿ࡡ࡞࠸ヰ࡟࡞ࡿࡢ࡛ࠊࡑ࠺⡆༢࡟ࡣゝ࠼ࡲࡏࢇࡀࠊࡑ࠺࠸࠺ࡇ࡜ࢆ᝿ᐃࡋ࡚࠸ࡿࡢࡔࢁ࠺࡜ᛮ࠸ࡲࡍࡼࡡࠊ ᖺᗘ࠿ࡽࡢᴫ⟬
ࡣࠋ

㸦すᮧ㸧
 ☜࠿࡟ศᏊ◊ࡀࡕࡻࡗ࡜ኚࢃࡗ࡚ࡁ࡚ࠊ
⏕≀⌧㇟࡟㠀ᖖ࡟⯆࿡ࢆᣢࡓࢀ࡚࠸ࡲࡍࠋ
㸦ᒣᮏ㸧 ࡑ࠺࡛ࡍࡡࠋ࠿࡞ࡾኚࢃࡾࡲࡋࡓࡡࠋ

− 99 −㸦すᮧ㸧 㠀ᖖ࡟㏆࠸ヰ࡟࡞ࡗ࡚ࡁ࡚࠸ࡿࡢ࡛ࡍࡼࡡࠋ࡛ࡍ࠿ࡽࠊࡲࡉ࡟࠾ࡗࡋࡷࡽࢀࡿ࡜
ࡇࢁࡀฟ࡚ࡃࡿ࠿ࡶࡋࢀࡲࡏࢇࠋ
㸦᳃㸧 ࡑ࠺࡛ࡍࠋࡇࢇ࡞ࡇ࡜ࢆゝࡗ࡚࠸࠸ࡢ࠿ศ࠿ࡾࡲࡏࢇࡀࠊࡇࡢ㛫ࡢ㐠Ⴀ఍㆟ࡢᚋ࡛⌧ᅾࡢศᏊ◊ᡤ㛗࡜ヰࡍᶵ఍ࡀ࠶ࡗ࡚ࠊࡑ࠺ࡋࡓࡽࠊࠕ஧ගᏊࡣ࠺ࡕࡣ  ᖺ๓࠿ࡽࡸࡗ࡚࠸
ࡿࡢࡔࡼࡡࠖ࡜ゝࡗ࡚࠸ࡲࡋࡓࠋ㸦すᮧ㸧 ࠺ࡕࡀጞࡵࡓࡳࡓ࠸࡞ឤࡌࡀ࠶ࡾࡲࡍࡼࡡࠋ
㸦᳃㸧 ࡛ࡍࡼࡡࠋࡔ࠿ࡽࠊࡇࡕࡽ࡜ࡋ࡚ࡣ㐃ᦠࡋࡓࡽ࠸࠸ࡢ࠿࡞࡜ᛮ࠸ࡲࡍࡼࡡࠋ
㸦஭ཱྀ㸧 ᇶ⏕◊࡜⏕⌮◊ࡢሙྜࡣࠊ⚾ࡣ⏕⌮◊ࡢඛ⏕࡜ࡣඹྠ◊✲ࢆࡋ࡚࠸ࡿࡢ࡛ࡍࡅࢀ
࡝ࡶࠊྠࡌ◊✲㈝ࢆྲྀࡗ࡚࠸ࡿࢃࡅ࡛ࡣ࡞࠸࡛ࡍࡋࠊࡇ࠺࠸࠺බࡢሙᡤ࡟࡝ࡢࡼ࠺࡟ฟࡍ࠿
࡜࠸࠺ࡢࡀ࡞࠿࡞࠿࡞࠸࡛ࡍࡡࠋ ࡑࢀ࠿ࡽࠊ⮬↛⛉Ꮫ◊✲ᶵᵓഃ࠿ࡽぢ࡚ࠊ౛࠼ࡤᇶ⏕◊࡜⏕⌮◊ࡀศ㔝㛫㐃ᦠ࡟ฟࡋࡓ࡜
ࡋ࡚ࡶࠊࡲࡎ㏻ࡽ࡞࠸ࡢ࡛ࡍࠋ
㸦᳃㸧 ㏻ࡽ࡞࠸ࡢ࡛ࡍ࠿ࠋ
㸦஭ཱྀ㸧 ᑂᰝဨࡀᚋ࡛ᩍ࠼࡚ࡃࢀࡓ࡜ࡇࢁ࡟ࡼࡿ࡜ࠊ
ࠕᇶ⏕◊࡜⏕⌮◊ࡀ୍⥴࡟⤌ࢇ࡛ฟࡋ࡚ࡶ↓⌮࡛ࡍࠖ࡜ࡢࡇ࡜࡛ࡍࠋྠࡌᒸᓮ࡟࠶ࡗ࡚ࠊࢃࢀࢃࢀ࡜ࡋ࡚ࡣูࡔ࡜ᛮࡗ࡚࠸ࡿࡢ࡛
ࡍࡀࠊୖ࠿ࡽぢࡿ࡜ྠࡌ࡜ࡇࢁ࡟࠸࡚ࠊᇶ⏕◊ࡶ⏕⌮◊ࡶྠࡌࠊ࡜࠸࠺ࡇ࡜࡟࡞ࡿࡑ࠺࡛ࡍࠋ
㸦㛗㇂㸧 ࡔ࠿ࡽࠊࡑࢀࡣศ㔝㛫㐃ᦠ࡜࠸࠺ࣉࣟࢪ࢙ࢡࢺࡢ㐃ᦠ࡞ࡢ࡛ࠊࡑࡇ࡟ࡣ⤌⧊࡜ࡋ࡚ࡢᨵᗫࡶᕤኵࡋࢁ࡜࠸࠺ὶࢀ࡟ከศ࡞ࡿࡢࡔࢁ࠺࡜ᛮ࠸ࡲࡍࠋ
㸦஭ཱྀ㸧 ࡴࡋࢁኳᩥྎ࡜⤌ࡵ࡜࠿ࠊࡑࡢࡼ࠺࡟ࡸࡽ࡞࠸࡜࡞࠿࡞࠿㞴ࡋ࠸࡜ࡇࢁࡶ࠶ࡿࡼ࠺࡛ࡍࠋ㸦すᮧ㸧 ๓ࡣ㑇ఏ◊࡜ࡢᕪู໬ࡀᇶ⏕◊ࡶ࡞࠿࡞࠿㞴ࡋ࠿ࡗࡓࡢ࡛ࡍࡀࠋ
㸦Ⲩᮌ㸧 ࡑࢀࡣᶵᵓࡀ㐪࠺࡜࠸࠺ࡢ࡛ࠋ㸦すᮧ㸧 ࡑ࠺࡞ࡢ࡛ࡍࡀࠊࡑࢀ࡟ຍ࠼࡚ࠊ⏕⌮◊ࠊศᏊ◊࡟ᑐࡋ࡚ࡶከศ࠿࡞ࡾ㏆ࡃ࡞ࡗ࡚ࡁ࡚࠸ࡿ࡜࠸࠺ࡇ࡜ࡀ࠶ࡾࡲࡍࠋ
㸦Ⲩᮌ㸧 ࡓࡔࠊእ࠿ࡽぢ࡚༢⣧࡞␲ၥࡣࡑࡇ࡟࠶ࡗ࡚ࠊࢃࢀࢃࢀࡣ⥲◊኱ࡢ఍㆟ࢆࢸࣞࣅ఍㆟࡛ࡸࡾࡲࡍࡀࠊ⏕⌮Ꮫᑓᨷࡢ᪉࡜ᇶ♏⏕≀Ꮫᑓᨷࡢ᪉ࡀ୪ࢇ࡛࠸ࡽࡗࡋࡷࡿࡅࢀ࡝ࠊࡑ
ࡢ୰࡟஺ὶࡀ୍య࡝ࢀࡔࡅ࠶ࡿࡢࡔࢁ࠺࠿࡜࠸࠺ࡇ࡜ࡣࠊ
ࢃࢀࢃࢀ࡟ࡣࡼࡃぢ࠼࡞࠸࡛ࡍࡡࠋ
− 100 −㸦すᮧ㸧 ࡑ࠺࡛ࡍࡡࠋ࡞࠿࡞࠿㐪࠺ࡢ࡛ࡍࡡࠋ
㸦ᒣᮏ㸧 ⏕⌮◊ࡣ◊✲ᑐ㇟ࡣࣄࢺ࡜࠸࠺ࡇ࡜ࢆ࠿࡞ࡾᙉࡃฟࡋ࡚࠾ࡽࢀࡿࡢ࡛ࠊࣄࢺࡀᑐ
㇟࡛ࡣ࡞࠸◊✲⪅ࡀ⏕⌮◊࡟ධࡗ࡚ࡃࡿࡢ࠿ࠊࡳࡓ࠸࡞ឤࡌ࡟࡜ࡽ࠼ࡽࢀ࠿ࡡ࡞࠸࡜ࡇࢁࡶ
࠶ࡾࡲࡍࠋ㸦すᮧ㸧 ⥲◊኱ࡢ⏕࿨⛉Ꮫ◊✲⛉ࡢᩍᤵ఍㆟࡛ࡶ኱య⌮ゎࡉࢀࡿ࠿ࡶࡋࢀࡲࡏࢇࡀࠊࡸࡣ
ࡾࡕࡻࡗ࡜㐪࠺ࡢ࡛ࡍࡡࠋ
㸦Ⲩᮌ㸧 㐪࠺ࡢࡣศ࠿ࡿࡢ࡛ࡍࡀࠋ㸦すᮧ㸧 ࡕࡻࡗ࡜᫬㛫ࡀ㉸㐣ࡋ࡚ࡋࡲ࠸ࡲࡋࡓࠋ
ࡇࡇ࡛㛢ࡌࡉࡏ࡚࠸ࡓࡔࡃ࡜࠸࠺ࡇ࡜࡛ࠊ
ᒣᮏᡤ㛗࠿ࡽ᭱ᚋࡢࡈᣵᣜࢆࠋ
㸦ᒣᮏ㸧 ᮏᙜ࡟௒᪥ࡣ㛗᫬㛫࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ࠸ࢁ࠸ࢁ⚾࡞ࡾ࡟ࡇ࠺࠸࠺࡜ࡇࢁ
ࢆ✺࠿ࢀࡿ࡜③࠸࡞࡜࠸࠺ࡼ࠺࡞ࡈពぢࡀࡕࡷࢇ࡜ฟ࡚ࡁࡲࡋࡓࠋᮏᙜ࡟┿ᦸ࡟⪃࠼ࡉࡏ࡚࠸ࡓࡔࡁࡓ࠸࡜ᛮࡗ࡚࠸ࡲࡍࠋᇶ⏕◊ࡣ௒ࡢ࡜ࡇࢁ඲య࡜ࡋ࡚◊✲࡟ᡴࡕ㎸ࡴ᪉ࠎࡀከࡃ࡚ࠊ
⚾ࡣࡲࡔ╔௵ᚋ༙ᖺవࡾ࡛ࡍࡅࢀ࡝ࡶࠊ࠶ࡿព࿡㠀ᖖ࡟ᒃᚰᆅࡢ࠸࠸ឤぬࢆᣢࡗ࡚࠸ࡲࡍࠋ
ࡇࢀ࠿ࡽ࡝ࡢࡼ࠺࡟ື࠸࡚࠸ࡃࡢ࠿࡜࠸࠺ࡇ࡜࡟ࡘ࠸࡚ࡶᚎࠎ࡟┿๢࡟⪃࠼࡚࠸࠿࡞࠸࡜࠸
ࡅ࡞࠸࡛ࡍࡋࠊࡑࢀ࠿ࡽࠊ࢞ࣂࢼࣥࢫࡢ࠶ࡾ᪉࡞࡝࡟ࡘ࠸࡚ࡶ࠺୍ᗘ෌Ⅼ᳨ࢆࡋ࡚࠸࠿࡞࠸
࡜࠸ࡅ࡞࠸࡜࠸࠺ࡇ࡜ࢆ௒᪥ࡣ࠶ࡽࡓࡵ࡚ᙉࡃឤࡌࡲࡋࡓࠋ௒ᚋ࡜ࡶᮏᙜ࡟ࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ㸦すᮧ㸧 ࡝࠺ࡶ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓࠋ

− 101 −

− 102 −４．外部点検評価アンケート結果− 103 −

እ㒊Ⅼ᳨ホ౯࢔ࣥࢣ࣮ࢺ
㸯㸧Ꮫ⾡◊✲࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
ᇶ⏕◊࡛ࡣࠊᇶ♏⏕≀Ꮫ࡛ୡ⏺ࢆඛᑟࡍࡿ◊✲ࢆ๰ᡂࠊ᥎㐍ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚࠸ࡲࡍࠋᖹᡂ 25ᖺᗘࡢ୺࡞ᡂᯝ࡟ࡘ࠸࡚ࡣ㈨ᩱ㸯ࠊᡂᯝࢆබ⾲ࡋࡓⓎ⾲ㄽᩥ࡟ࡘ࠸࡚ࡣ㈨ᩱ㸰㸦ᖺᗘ࡛ࡣ࡞ࡃᖺ
༊ษࡾ࡛ࡍࡢ࡛ⱝᖸࡢࡎࢀࡀ࠶ࡾࡲࡍ㸧ࢆཧ↷ࡋ࡚࠸ࡓࡔࡁࠊᡤෆ◊✲⪅ࡢ◊✲Ỉ‽࡞ࡽࡧ࡟◊✲ෆᐜ࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋࡲࡓࠊ௒ᚋ⏕≀Ꮫ࡟ࣈࣞ࢖ࢡࢫ࣮ࣝࢆࡶࡓࡽࡍ◊✲ࢆ⫱࡚ࠊᒎ㛤ࡋ࡚࠸ࡃࡓࡵ࡟ࠊ◊✲ᡤࡀ࡝ࡢࡼ࠺࡞௙⤌ࡳࢆᣢࡘ࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋࡓࡽ
࠾⪺࠿ࡏୗࡉ࠸ࠋ
ពぢ㸯 ᮇᚅ㏻ࡾࡢ⯆࿡῝࠸ᇶ♏◊✲ᡂᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ᳜≀࡛ࡣࠊ⣽⬊ศ⿣᫬ࡢᚤᑠ⟶ࡢືែ࡟㛵ࡍࡿ◊✲ࠊගྜᡂࡢࢫࢸ࣮ࢺ㑄⛣ᶵᵓࡢゎ᫂ࠊ࣐࣓⛉᳜≀ࡢ᰿⢏ᩘไᚚࢩࢢࢼࣝศᏊ
ࡢᵓ㐀ゎ᫂ࠊ᳜≀࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ࣮࢜ࢺࣇ࢓ࢪ࣮ศゎࠊ࢜ࢪࢠࢯ࢘㑇ఏᏊ᧯సἲࡢ☜❧࡞࡝ࠊ⊂⮬ᛶࡢ㧗࠸ඃࢀࡓᡂᯝࡀ┠❧ࡗࡓࠋࡲࡓࠊື≀ࢆᮦᩱ࡜ࡍࡿ◊✲࡛ࡶࠊ࣑ࢪࣥ
ࢥࡢᛶᨩ஘ࡢ௙⤌ࡳࠊ࣐࢘ࢫ⬇ࡢཎ⭠㝗ධࡢ㧗ゎീᗘ࣭㛗᫬㛫᧜ᙳࠊ኱⬻⓶㉁㑇ఏᏊⓎ⌧ࡢ࢚ࣆࢤࣀ࣒ไᚚࡸ୍⣽⬊ไᚚ⣔࡞࡝ࡢ⯆࿡῝࠸ᡂᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ᪂ศ㔝ࡢ㛤ᣅ᥎㐍࡜ࠊⱝᡭ⊂❧◊✲⪅࡬ࡢᣦᑟయไ㸦࣓ࣥࢱ࣮ไᗘ࡞࡝㸧☜❧ࡀᮃࡲࢀࡿࠋ
ពぢ㸰 ୍ᖺ㛫ࡢࡳࡢ◊✲ᴫせࡸ publication ࢆᣏぢࡋ࡚ࠊ◊✲Ỉ‽࡟㛵ࡋ࡚ពぢࡍࡿࡇ࡜ࡣᐜ᫆
࡛ࡣ࠶ࡾࡲࡏࢇࡀࠊ඲య࡜ࡋ࡚ࠊ࢜ࣜࢪࢼࣜࢸ࢕࣮ࡢ㧗࠸࡜ᛮࢃࢀࡿㄽᩥࡸ࢖ࣥࣃࢡࢺࡀ
ᮇᚅࡉࢀࡿㄽᩥࡀ」ᩘぢࡽࢀ࡚ࠊ㉁ࡢ㧗࠸⊂⮬ࡢ◊✲ࡀᒎ㛤ࡉࢀ࡚࠸ࡿ࡜ឤࡌࡲࡋࡓࠋ୍
᪉ࠊ◊✲㡿ᇦࡸ᪉ྥᛶࡀከᒱ࡟Ώࡗ࡚࠾ࡾࠊ◊✲ᡤࡢ඲య࡜ࡋ࡚ࡢホ౯ࢆཷࡅࡿ࡟ࡣࠊࡸ
ࡸ୙฼࡞ࡼ࠺࡞Ẽࡶࡋࡲࡍࠋࡶࡋࠊ◊✲ᡤ࡜ࡋ࡚ࡢ኱ࡁ࡞ࢸ࣮࣐࡜࠸࠺࠿᪉ྥᛶࡀ 2-3 タᐃࡉࢀ࡚࠸࡚ࠊࡑࢀ࡟ἢࡗ࡚⥲ྜホ౯ࢆ࠺ࡅࡿ࡜࠸࠺ࡢࡀࢃ࠿ࡾ᫆࠸࡜ឤࡌࡲࡋࡓࠋ
ពぢ㸱 ᖹᡂ 25 ᖺᗘ࡟࠾࠸࡚ࠊ⏕࿨⌧㇟ࡢᇶᮏཎ⌮ࡢ⌮ゎࢆ῝ࡵࡿ◊✲ࢆࠊ⣽⬊⏕≀ᏛࠊⓎ⏕⏕≀Ꮫࠊ⚄⤒⏕≀Ꮫࠊ㐍໬ከᵝᛶ⏕≀Ꮫࠊ⎔ቃ⏕≀Ꮫ➼ࡢ㡿ᇦ࡟࠾࠸࡚᥎㐍ࡋ࡚࠸ࡿࠋ㧗࠸࢖ࣥࣃࢡࢺࣇ࢓ࢡࢱ࣮ࡢᏛ⾡ㄅ࡟ࡶከࡃࡢㄽᩥࡀᥖ㍕ࡉࢀ࡚࠾ࡾࠊᇶ♏⏕≀Ꮫ࡛ୡ⏺ࢆඛᑟࡍࡿࡇ࡜ࢆᛕ㢌࡟࠾࠸ࡓ◊✲ࡀ࡞ࡉࢀ࡚࠸ࡿࡇ࡜ࡀឤࡌࡽࢀࡿࠋࡇࡢࡇ࡜࠿ࡽࡶࠊᡤෆ
◊✲⪅ࡢ㧗࠸◊✲Ỉ‽ࡀ⌮ゎ࡛ࡁࡿࠋࡓࡔࠊ௒ᚋ⏕≀Ꮫ࡟ࣈࣞ࢖ࢡࢫ࣮ࣝࢆࡶࡓࡽࡍࡼ࠺
࡞◊✲ࡣࠊᚲࡎࡋࡶࡇࡢࡼ࠺࡞Ꮫ⾡ㄅ࡟ฟࡿࡶࡢ࡜ࡣ㝈ࡽ࡞࠸ࡢ࡛ࠊ㐣ᗘ࡟㧗࠸࢖ࣥࣃࢡ
ࢺࣇ࢓ࢡࢱ࣮ࡢᏛ⾡ㄅࢆ┠ᣦࡍࡇ࡜࡞ࡃࠊ⌧ᅾࡢὀ┠ᗘࡣ㧗ࡃ࡞ࡃ࡜ࡶࠊࡋࡗ࠿ࡾ࡜ࡋࡓ
◊✲࢚ࣅࢹࣥࢫ࡟ᇶ࡙࠸ࡓ◊✲࡟ࡶ༑ศ࡟ὀຊࡍ࡭ࡁ࡛࠶ࡿࠋ
ពぢ㸲 ᭱㏆ࡢ⏕≀Ꮫࡢഴྥࡣࠊ࢔࢘ࢺࣉࢵࢺࡢ㔜どࠊ≉࡟ࠊᐇᏛⓗ࡞ᛂ⏝ࢆồࡵࡿഴྥ࡟࠶ࡿࠋ
ࡋ࠿ࡋࠊᛂ⏝ⓗ࡞◊✲ࡶࠊᇶ♏ⓗ࡞▱㆑ࡸᢏ⾡ࡢ⵳✚ࡢୖ࡟ᡂࡾ❧ࡕࠊࡉࡽ࡟ࠊᇶ♏ࡢ┿ࡢ☜❧࡟ࡶ⭾኱࡞᫬㛫ࢆせࡍࡿࡇ࡜⌮ゎࡍࡿᚲせࡀ࠶ࡿࠋᇶ♏ⓗ࡞⛉Ꮫࡀࠊᛂ⏝ࡶྠ᫬࡟┠ᣦࡍࡇ࡜ࡣᝏ࠸ࡇ࡜࡛ࡣ࡞࠸ࡀࠊ⣧⢋࡟⏕≀ࡢ୙ᛮ㆟ࡉࡸᕦጁࡉࢆ⌮ゎࡋࡼ࠺࡜ࡍࡿᏛၥࡣ㔜せ࡛ࠊ◊✲㈝ࡢ㓄ศࡀᛂ⏝㠃࡬ࡢᐤ୚ᗘ࡟౫Ꮡࡋ࡞
࠸࡜බゝ࡛ࡁࡿ◊✲ࡣᚲ㡲࡛࠶ࡿࠋ− 105 −

ᇶ⏕◊࡛ࡢ⌧ᅾࡢ◊✲ෆᐜࢆᴫほࡍࡿ࡜ࠊࣁ࢚࠿ࡽ᳜≀ࡲ࡛ᑐ㇟ࡀᗈࡃᏑᅾࡍࡿࠋ኱Ꮫࡢ
ࡼ࠺࡞ᩍ⫱ࢆ㸯ࡘࡢᰕ࡜ࡍࡿᶵ㛵࡜ࡣ㐪ࡗࡓࢩࢫࢸ࣒ࡢ୰࡛ࡇࡑྍ⬟࡞ࠊ㉁ࡢ㧗࠸ゎᯒࢆ⥔ᣢࡋ࡚࠸ࡓࡔࡁࡓ࠸ࠋ࠸ࡎࢀࡢศ㔝࡛ࡶࠊᴗ⦼ࡀࡳࡽࢀࠊᡂᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ
௒ᚋ⏕≀Ꮫ࡟ࣈࣞ࢖ࢡࢫ࣮ࣝࢆࡶࡓࡽࡍ◊✲ࢆ⫱࡚ࠊᒎ㛤ࡋ࡚࠸ࡃࡓࡵ࡟ࠊᅜෆእࢩ࣏ࣥ
ࢪ࣒࢘ࡢ௻⏬࡞࡝ࢆࡉࡽ࡟᥎㐍ࡍ࡭ࡁ࡜ᛮࢃࢀࡿࠋሙᡤࡣ฼౽ᛶࡢࡼ࠸࡜ࡇࢁࡶࡼ࠸࠿࡜
ᛮࢃࢀࠊ◊✲ᡤ௨እ࡛ࡶࠊᇶ⏕◊ࡸࠊ࠶ࡿ࠸ࡣࠊ௚࡜ࡢඹྠ࡛࡛ࡶࠊ࢔ࣆ࣮࡛ࣝࡁࡿࡇ࡜ࡀ㔜せ࠿࡜ᛮࢃࢀࡿࠋ
୍᪉࡛ࠊ≧ἣ࡜ࡋ࡚ࠊ◊✲ࡀࣞ࣋ࣝ࢔ࢵࣉࡋ࡚ከᴟ໬ࡍࡿ࡞࠿ࠊ᪥ᮏࡢ◊✲࡟࠾ࡅࡿᖺ㱋ไ㝈࡟ࡘ࠸࡚ࠊṧᛕ࡞ࡇ࡜ࡔ࡜ᛮ࠺ࡇ࡜ࡀከࡃࠊᖺ㱋࡟ࡼࡽࡎࠊ࠸ࢃࡺࡿ biological ageࢆၥ㢟࡟ࡏࡎࠊάື࡛ࡁࡿయไࢆษࡾ㛤ࡃࡇ࡜ࡶ㔜せ࡞ࡇ࡜࡛ࡣ࡞࠸࠿࡜ᛮࢃࢀࡿࠋ
Positive ࡞ព࿡࡛ࠊᖺ㱋ไ㝈ࢆ㉸࠼࡚ࠊάື࡛ࡁࡿయไࢆࠊࡁࡕࢇ࡜ࡦࡃࡇ࡜ࡢ࡛ࡁࡿྍ
⬟ᛶࡶ◊✲ᡤ࡞ࡽ࡛ࡣࠊࡢࡇ࡜࡜ᛮࢃࢀࡿࠋ

ពぢ㸳 ᖜᗈ࠸ศ㔝࡛⥅⥆ⓗ࡟ඃࢀࡓ◊✲ࡀ࡛࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋ≉࡟᳜≀ศ㔝࡛ࡢᯇᯘ◊ࠊᕝཱྀ◊࡟ࡼࡿඃࢀࡓඹྠ◊✲ᡂᯝࡣࠊඹྠ฼⏝◊࡜ࡋ࡚ࡢᶵ⬟ࢆ⮬ࡽ♧ࡍࡇ࡜࡟ᡂຌࡋ࡚࠸࡚
኱ኚࡍࡤࡽࡋ࠸࡜ᛮ࠸ࡲࡍࠋᡤෆ࡛ࡢඹྠ◊✲ࡀ௒ᚋ୍ᒙάⓎ໬ࡍࡿ࡜ᇶ⏕◊ࡢ≉ᚩ࡟ࡘ࡞ࡀࡿ࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸴 Ⓨ⾲ࡉࢀࡓㄽᩥࡢከࡃࡀࢺࢵࣉࢪ࣮ࣕࢼࣝ࡟ᥖ㍕ࡉࢀ࡚࠸ࡿࡇ࡜࠿ࡽࡳ࡚ࡶࠊ◊✲ෆᐜ࡜ࡑࡢỈ‽ࡢ㧗ࡉࡣࠕࡉࡍࡀࠖ࡜ゝࢃࡊࡿࢆᚓ࡞࠸ࠋ
㧗࠸◊✲ෆᐜ࡜Ỉ‽ࢆࠕ⥔ᣢࡍࡿࠖࡓࡵ࡟ࡣࠊ㙾ࡢᅜࡢ࢔ࣜࢫ࡟ฟ࡚ࡃࡿࠕ㉥ࡢዪ⋤㸦Red
Queen㸧ࠖ࡜ྠࡌࡃ඲ຊ࡛㉮ࡽ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ◊✲ᶵ㛵࠾ࡼࡧ◊✲⪅ࡣࠊከ࠿ࢀᑡ࡞
࠿ࢀ Red Queen ≧ែ࡛࠶ࡿࡀࠊ᭦࡟୍Ṍ๓࡟㐍ࡴ Far Red Queen ࡟࡞ࡿ࡟ࡣࠊ࡝࠺ࡋࡓ
ࡽࡼ࠸ࡢ࠿ࠋࡇࢀ࡜ゝࡗࡓጁ᱌ࡣ࠶ࡾࡲࡏࢇࡀࠊ⮬ศࡢࡇ࡜ࡣᲴ࡟ୖࡆࡿ࡜ࡋ࡚ࠊࡑࡇࢆ
┠ᣦࡋ࡚㡬ࡁࡓ࠸ࠋ

ࡲࡓ㸦๓ᅇࡶ㏙࡭ࡓ࠿ࡶࡋࢀࡲࡏࢇࡀ㸧௒ᚋࡣࠊࡇࢀࡲ࡛ࡢ◊✲ࢆᇶ┙࡜ࡋ࡚ࠊ⏕≀ಶయࣞ࣋ࣝ࡟࡜࡝ࡲࡽࡎࠊ⏕≀㛫ࡢ┦஫స⏝➼ࡢ⏕ែᏛⓗどⅬࡲ࡛ྵࡵࡓ࣐ࢡࣟ⏕≀Ꮫࡢᇶ♏
◊✲ࢆศᏊ⏕≀Ꮫⓗᡭἲ࡛ྲྀࡾ⤌ࡴࡼ࠺࡞௙⤌ࡳࢆᮇᚅࡋࡓ࠸ࠋ࡞࠾ࠊ⥲ྜᆅ⌫⎔ቃᏛ◊✲ᡤ㸦ᆅ⌫◊㸧࡛ࡣᩥ⌮⼥ྜࢆᶆᴶࡋ࡚࠾ࡾࠊࡲࡓ◊✲యไࡶ␗࡞ࡿࡢ࡛ࠊ࣐ࢡࣟ⏕≀Ꮫࡢᇶ♏◊✲ࡣ⌧≧ࡢᆅ⌫◊࡛ࡣᐇ᪋࡛ࡁ࡞࠸ࡓࡵᕪู໬ࡢᚲせࡣ↓࠸࡜ᛮࢃࢀࡿࠋ

㸰㸧ඹྠ฼⏝࣭ඹྠ◊✲࡟㛵ࡍࡿάື࡟ࡘ࠸࡚IBBP ࢭࣥࢱ࣮㸦኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺࢭࣥࢱ࣮㸧࡛ࡣ⏕≀㑇ఏ㈨※ࡢࣂࢵࢡ࢔ࢵࣉࢆ᥎㐍ࡍࡿ࡜࡜ࡶ࡟ࠊࡼࡾከᵝ࡞⏕≀㑇ఏ㈨※ࢆࣂࢵࢡ࢔ࢵࣉಖ⟶࡛ࡁࡿయไࢆᶞ❧ࡍࡿࡇ࡜ࢆ┠ᣦࡋ࡚ࠊ⏕≀㑇ఏ㈨※᪂つಖᏑᢏ⾡㛤Ⓨඹྠ฼⏝◊✲ࢆ㛤ጞࡋࡲࡋࡓࠋ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ᡤᒓࡢ᭱ඛ➃ᶵჾࡢඹྠ฼⏝࣭ඹྠ◊✲ࢆᘬࡁ⥆ࡁ✚ᴟⓗ࡟᥎㐍ࡍࡿ࡜࡜ࡶ࡟ࠊ◊✲⪅ࡢࡓࡵࡢᐇ⩦ࢥ࣮ࢫ࣭ࢭ࣑ࢼ࣮㛤ദࢆ㏻ࡌ࡚ࢧ࣏࣮ࢺࢆᐇ᪋ࡋࡲࡋࡓࠋࡲࡓࠊࣔࢹࣝ⏕≀◊✲ࢭࣥࢱ࣮࡛ࡣࠊ࣓ࢲ࢝ཬࡧ࢔ࢧ࢞࢜ࣂ࢖࢜ࣜࢯ࣮ࢫࡢᥦ౪ࢆ㏻ࡌ࡚◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࡟ࢧ࣮ࣅࢫ
ࢆᥦ౪ࡋ࡚࠸ࡲࡍࠋගࢩ࣮ࢺᆺ㢧ᚤ㙾㸦DSLM㸧ࢆᨵⰋࡋ࡚㸰ගᏊ DSLM ࡜ࡋᗈど㔝࣭㧗⢭⣽ᗘほᐹ࡟ᡂຌࡋࡲࡋࡓࠋ㈨ᩱ㸯࡟ࡲ࡜ࡵࡓࡇࢀࡽࡢάື࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋࡲࡓࠊ

− 106 −

௒ᚋࠊ኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ᇶ⏕◊ࡀ࡝ࡢࡼ࠺࡞ᙺ๭ࢆᯝࡓࡍ࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋࡓ
ࡽ࠾⪺࠿ࡏୗࡉ࠸ࠋ
ពぢ㸯 ᇶ♏⏕≀Ꮫ◊✲ᡤࡣ඲ᅜࡢ኱Ꮫ࣭◊✲ᶵ㛵࡜ከᩘࡢඹྠ◊✲ࢆᐇ᪋ࡋ࡚࠾ࡾࠊᡃࡀᅜࡢᇶ
♏⛉Ꮫ࡟ྲྀࡗ࡚୙ྍḞ࡞㈉⊩ࢆࡋ࡚࠸ࡿࠋḟୡ௦ࢩ࣮ࢡ࢚ࣥࢧ࣮ࡢゎᯒࢺ࣮ࣞࢽࣥࢢࢥ࣮
ࢫࠊ㉥እ࣮ࣞࢨ࣮㑇ఏᏊⓎ⌧ㄏᑟ㢧ᚤ㙾㸦IR-LEGO㸧ࡸගࢩ࣮ࢺᆺ㢧ᚤ㙾(DSLM)࡞࡝ࡢ
⊂⮬ᛶࡢ㧗࠸ᶵჾࡢඹྠ฼⏝ࡶ᭷ຠ࡟࡞ࡉࢀ࡚࠸ࡿࠋࡲࡓࠊྛ✀ࣂ࢖࢜ࣜࢯ࣮ࢫࡢಖ⟶ࡸࠊ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦IBBP㸧ࡣࠊ㟈⅏᫬ࡢᡃࡀᅜࡢ◊✲㈨※ࡢࣂࢵࢡ࢔ࢵࣉ࡜ࡋ࡚㠀ᖖ࡟㔜せ࡛࠶ࡿࠋពぢ㸰 ᗄࡘࡶࡢάືࡀάⓎ࡟࡞ࡉࢀ࡚࠾ࡾࠊ኱࠸࡟㈉⊩ࡋ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋඛ➃ᶵჾࢆ⏝࠸ࡿඛ➃ᢏ⾡ࡣࠊᶵჾ㢮ࡢࢧ࣏࣮ࢺయไ࡜ࠊࡑࡢேဨ㸦ᢏ⾡ᨭ᥼෸ᩍᤵࡸຓᩍ➼ࡢ◊✲ဨ࣭ᩍဨ㸧ࡢ࢟ࣕࣜ࢔ࣃࢫࢆ⪃࠼ࡓࢧ࣏࣮ࢺయไࡢᩚഛࡀᚲ㡲࡛ࡍࠋ඲ᅜࡢ୰᰾኱Ꮫࡸ◊✲ᶵ㛵࡟࠾࠸࡚ࡶඛ➃ᶵჾ࣭ᢏ⾡ᨭ᥼ࣘࢽࢵࢺࡣᚲ㡲࡛ࡍࡢ࡛ࠊࡑࡢࣉࣟࢺࢱ࢖ࣉࡢࡼ࠺࡞⤌⧊ࢆసࡗ࡚㡬ࡁࡓ࠸࡜ᛮ࠸ࡲࡍࠋࡲࡓࠊࡑࡢࡼ࠺࡞ࣘࢽࢵࢺࡢ඲ᅜⓗ࡞ࢿࢵࢺ࣮࣡ࢡసࡾࡶ
ᮏ┬࡬ࡢせồ࡜ࡋ࡚᭷ຠ࠿ࡶ▱ࢀࡲࡏࢇࠋ
ពぢ㸱 㸯㸧⏕≀ᶵ⬟᝟ሗศᯒᐊ㸸ᇶ♏⏕≀Ꮫ᥎㐍࡟ᚲ㡲ࡢࢶ࣮ࣝ࡜࡞ࡾࡘࡘ࠶ࡿḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮ࡢඹྠ฼⏝ᐇ㦂ࢆࠊ41 ௳ᐇ᪋ࡋࡓࡇ࡜ࡣホ౯࡛ࡁࡿࠋࡑࡢᡂᯝ࡜ࡋ࡚ࠊ11 ⦅ࡢㄽᩥࢆⓎ⾲ࡋ࡚࠸ࡿࡇ࡜࠿ࡽࡶࠊࡑࢀࡽࡢඹྠ◊✲ࡀ᭷ຠ࡛࠶ࡗࡓࡇ࡜ࡀ⌮ゎ࡛ࡁࡿࠋࢤࣀ࣒࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ࣭ࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࡢ㛤ദࡣࠊḟୡ௦ࡢ◊✲⪅⫱ᡂ࡟࡜ࡗ࡚
ࡶ㔜せ࡜⪃࠼ࡿࠋ
㸰㸧ගᏛゎᯒᐊ㸸56 ௳ࡢඹྠ฼⏝◊✲࡜ࠊࢸࢡࢽ࢝ࣝࢭ࣑ࢼ࣮ࠊᐇ㦂ࢺ࣮ࣞࢽࣥࢢࢥ࣮
ࢫࡢ㛤ദ➼ࠊඹྠ฼⏝ᐇ㦂᪋タ࡜ࡋ࡚ࡢ㧗࠸ࣃࣇ࢛࣮࣐ࣥࢫࡀឤࡌࡽࢀࡓࠋ
㸱㸧ගࢩ࣮ࢺᆺ㢧ᚤ㙾ඹྠ฼⏝ᐇ㦂㸸᪂ࡓ࡞ᡭἲ࡟ࡼࡿࣛ࢖ࣈ࢖࣓࣮ࢪࣥࢢἲࡢ☜❧ࡀ࡞ࡉࢀࠊ௒ᚋࡢᒎ㛤࡟ᮇᚅࡀᣢ࡚ࡿᡂᯝࡀᚓࡽࢀ࡚࠸ࡿࠋ
㸲㸧࣓ࢲ࢝ࣂ࢖࢜ࣜࢯ࣮ࢫ㸸㑇ఏᏛⓗ◊✲ࡢᮦᩱ࡜ࡋ࡚㔜せ࡛࠶ࡿ࣓ࢲ࢝ࡢࣜࢯ࣮ࢫ☜ಖࡢࡓࡵ࡟㔜せ࡛࠶ࡿࠋኚ␗యࢫࢡ࣮ࣜࢽࣥࢢࢩࢫࢸ࣒ࡢᥦ౪ࡸࠊ㏆⦕✀ BAC ࢡ࣮ࣟࣥࡢ
ᥦ౪ࡢ㛤ጞ࡞࡝ࠊάⓎ࡞άືࡀ⾜ࢃࢀ࡚࠸ࡿࠋ
㸳㸧࢔ࢧ࢞࢜ࣂ࢖࢜ࣜࢯ࣮ࢫ㸸࣓ࢲ࢝࡜ྠᵝ࡟ࠊ㔜せ࡞◊✲ࢶ࣮࡛ࣝ࠶ࡾࠊBAC ࢡ࣮ࣟࣥࡢ཰㞟ࡸࠊDNA ࢡ࣮ࣟࣥࡢᥦ౪➼ࠊ㔜せ࡞άືࡀ⾜ࢃࢀ࡚࠸ࡿࠋ
㸴㸧᳜≀⛉Ꮫ᭱ඛ➃◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡ㸸ᅜ㝿ⓗ࡟⾜ࢃࢀࡓࠊ⏬ീࢹ࣮ࢱ㓄ಙᆺࡢ᳜≀⎔ቃไᚚࢩࢫࢸ࣒ࠊ⸴㢮ࡢගྜᡂᶵ⬟ゎᯒ⿦⨨ࠊḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮࡞࡝ࡢඹྠ฼⏝ࡣホ౯࡛ࡁࡿࠋ
㸵㸧኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸸⅏ᐖ᫬࡟㈗㔜࡞⏕≀ࢧࣥࣉࣝࡀኻࢃࢀࡿ
ࡇ࡜ࡀ࡞࠸ࡼ࠺࡟ࠊᅜෆࡢ 7 ኱Ꮫ࡜㐃ᦠࡋࡓ኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦IBBP㸧ࡣࠊ㧗ࡃホ౯ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ௒ᚋࠊ᪂つࣔࢹࣝ⏕≀ࡢ
㛤Ⓨ◊✲࡜ඹ࡟ᣑ඘ࡍ࡭ࡁ㔜せㄢ㢟࡛࠶ࡿ࡜⪃࠼ࡿࠋពぢ㸲 ⏕≀ᶵ⬟᝟ሗศᯒᐊࡸᕤᏛゎᯒᐊ࡞࡝◊✲ᡤෆ࡛ࡢඹ㏻ᶵჾࡢ⟶⌮࣭㐠Ⴀ࣭ຓゝ࡟ࡼࡾࡀ᭷ຠ࡟ാࡁࠊෆእࡢඹྠ◊✲ࡀࡍࡍࢇࡔࡇ࡜ࡣホ౯࡟್ࡍࡿࠋಶࠎࡢ◊✲ᐊᣢࡕ࡛ࡣ࡞࠸ࠊ

− 107 −

◊✲ᡤࡢඹ㏻ᶵჾࡢ᭷ຠ฼⏝ࡣ◊✲ࡢࡋࡸࡍࡉࠊ◊✲㈝ࡢຠ⋡ⓗ࡞౑⏝࡞࡝ࡢⅬ࠿ࡽⰋ࠸ࡇ࡜࡜ᛮࢃࢀࡿࠋ
ᇶ⏕◊ࡢ IBBP ࢭࣥࢱ࣮㸸⏕≀㑇ఏᏊ㈨※ࡢࣂࢵࢡ࢔ࢵࣉࢆࢧ࣏࣮ࢺࡍࡿయไ࡛࠶ࡿࡀࠊ
ࡏࡗ࠿ࡃࡢయไ࡛࠶ࡿࡢ࡛ࠊࡶ࠺ᑡࡋ࢔ࣆ࣮ࣝࡀ࠶ࡗ࡚ࡶⰋ࠸ࡼ࠺࡟ᛮࢃࢀࡿࠋࡲࡓࠊ⌮◊ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࢭࣥࢱ࣮ࡸ⇃ᮏ኱Ꮫࡢ CARD ࡜ࡢᕪู໬࡟ຍ࠼ࠊ༠ຊయไࡶⓎᒎࡍࡿ࡜Ⰻ࠸ࡼ࠺࡟ᛮࢃࢀࡿࠋ
࢔ࢧ࢞࢜ࣂ࢖࢜ࣜࢯ࣮ࢫ࡞࡝ࠊᇶ⏕◊࡛ࡇࡑࡢࣜࢯ࣮ࢫࡢࡉࡽ࡞ࡿⓎ㐩ࡶᮇᚅࡉࢀࡿࠋࡲ
ࡓࠊ᳜≀⛉Ꮫ᭱ඛ➃◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡ࡞࡝⎔ቃ㛵㐃ࢩࢫࢸ࣒ࡶ⊂๰ⓗ࡛࠶ࡾࠊ௒ᚋࡢ
ᒎ㛤ࡀᮇᚅࡉࢀࡿࠋ
ᅜෆ◊✲ᶵ㛵ᡤᒓࡢ㠀ᑓ㛛ᐙࡀࠊ࠶ࡲࡾᵓ࠼ࡎ࡟ཷㅮ࡛ࡁࡿᑓ㛛ᢏ⾡ㅮ⩦఍࡞࡝ࢆ✚ᴟⓗ࡟㛤ദࡋ࡚ࠊ௒ᚋࡶࠊᅜෆ◊✲⪅ࡢᇶ♏ᢏ⾡ࡢྥୖ࡟ᐤ୚࠸ࡓࡔࡅࡓࡽ࡜ᛮ࠺ࠋ
ពぢ㸳 ඹྠ฼⏝◊✲ࡢ㉁࡜ᩘࡢୖ࡛ࠊࡍ࡛࡟༑ศ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸴 ඲ᅜ኱Ꮫඹྠ฼⏝࣭ඹྠ◊✲᪋タ࡜ࡋ࡚ᵝࠎ࡞ྲྀࡾ⤌ࡳࢆࠊ⤌⧊ⓗࠊయ⣔ⓗ࡟⢔ࠎ࡜㐍ࡵ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋࡓࡔࠊࡇࢀࡔࡅࡓࡃࡉࢇࡢάືࢆᐇ᪋ࡍࡿ࡜ᩍ⫋ဨ࡬ࡢ㈇ᢸࡀ኱ࡁࡍ
ࡂࡿࡢ࡛ࡣ࡞࠸࠿༴᝹ࡍࡿࠋྛᩍဨ࡟ࡣࠊ㈇ᢸ㍍ῶࡢࡓࡵࡢࡉࡽ࡞ࡿேⓗ࡞ࢧ࣏࣮ࢺࡀ୙
ྍḞ࡛ࡋࡻ࠺ࠋ
௒ᚋ኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ᯝࡓࡍᙺ๭࡟㛵ࡋ࡚ࡣࠊ⌧ᅾࠊྛ኱Ꮫ࡟タ⨨ࡉࢀ࡚࠾ࡾࠊศ
㔝ࡀ㛵㐃ࡍࡿඹྠ฼⏝࣭ඹྠ◊✲ᣐⅬ࡜ࡢᙺ๭ศᢸ࡜㐃ᦠࢆ㐍ࡵ࡚ࡣ࡝࠺࠿㸦ࡼࡅ࠸࡞௙
஦ࢆቑࡸࡍࡼ࠺࡛ࡍࡀ㸧ࠋ㸱㸧ᅜ㝿㐃ᦠཬࡧᗈሗ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
ḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸦EMBL㸧ࠊ࣐ࢵࢡࢫࣉࣛࣥࢡ᳜≀⫱✀Ꮫ◊✲ᡤࠊࢸ࣐ࢭࢡ⏕࿨⛉Ꮫ◊✲ᡤ࡞࡝ࡢᾏእࡢ୺せ◊✲ᶵ㛵࡜㐃ᦠࡋᅜ㝿ඹྠ◊✲ࢆᐇ᪋ࡋࠊࢥࣥࣇ࢓ࣞࣥࢫࡸᐇ⩦ࢥ࣮ࢫࢆ㛤ദࡍࡿ࡜࡜ࡶ࡟ࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫࢆ㛤ദࡋࡲࡋࡓࠋࡲࡓࠊಶࠎࡢ◊✲ᐊ࡛ࣞ࣋ࣝࡢᅜ㝿ඹྠ◊✲ࢆࢥ࢔࡜ࡋࡓࠕ࣎ࢺ࣒࢔ࢵࣉᆺࠖᅜ㝿㐃ᦠࡢࢩࢫࢸ࣒ࢆ❧ࡕୖࡆࡲࡋࡓࠋᗈሗ࡛ࡣࠊ࣮࣒࣍
࣮࣌ࢪ࡟ຍ࠼࡚ࠊweb ࣐࢞ࢪࣥࠊFacebookࠊTwitter ➼ࡢ᪂ࡋ࠸፹య࡟ࡼࡿᗈሗࡢᙉ໬ࢆ⾜࠸ࡲࡋࡓࠋࡲࡓࠊ◊✲ᡤ୍⯡බ㛤ࢆᐇ᪋ࡍࡿ࡜࡜ࡶ࡟ࠊᑠ࣭୰࣭㧗ᰯ⏕ᑐ㇟ࡢᤵᴗࡸᐇ⩦ࡶ㛤ദࡋࡲ
ࡋࡓࠋ㈨ᩱ㸯࡟ࡲ࡜ࡵࡓࡇࢀࡽࡢάື࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋࡲࡓࠊ௒ᚋࠊᇶ⏕◊ࡣᅜ㝿㐃ᦠཬࡧ♫఍࡜ࡢ㐃ᦠ࡟㛵ࢃࡿᗈሗάືࢆ࡝ࡢࡼ࠺࡟㐍ࡵࡿ࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋࡓ
ࡽ࠾⪺࠿ࡏୗࡉ࠸ࠋ
ពぢ㸯 EMBL ࡸ࣐ࢵࢡࢫࣉࣛࣥࢡ᳜≀⫱✀Ꮫ◊✲ᡤ࡞࡝࡜ࡢඹྠ◊✲ࡣࠊᩍဨ࣭࣏ࢫࢻࢡ࣭኱
Ꮫ㝔⏕ࡢὴ㐵ࠊඹྠ◊✲ᡂᯝࡢウ㆟ࡸⓎ⾲ࡀάⓎ࡟࡞ࡉࢀ࡚࠾ࡾࠊ୧◊✲ᡤ࡟࡜ࡗ࡚┦஌ⓗ࡞ຠᯝࢆⓎ᥹ࡋ࡚࠸ࡿࠋࡲࡓࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫࡣ㸯㸮㸮ྡᙅࡢཧຍ⪅ࢆ㞟ࡵࠊᑗ᮶ࡢ◊✲࡟ࡘ࠸࡚ࡢウ㆟࡛㔜せ࡞᪉ྥᛶࡀᚓࡽࢀࡓ࡜ࡢࡇ࡜࡛࠶ࡾࠊព⩏ࡢ㧗࠸άື࡛࠶
ࡿ࡜⪃࠼ࡽࢀࡿࠋ࣮࣒࣮࣍࣌ࢪࡸ facebookࠊࡲࡓࣉࣞࢫ࣮ࣜࣜࢫάືࡸࢧ࢖࢚ࣥࢫࢫࢡ
࣮ࣝ࡬ࡢ༠ຊࡶ✚ᴟⓗ࡟⾜ࢃࢀ࡚࠸ࡿࠋᕷẸࢆᑐ㇟࡜ࡋࡓㅮ₇఍ࡶ┒ἣ࡛࠶ࡾࠊ࢔࢘ࢺࣜ
࣮ࢳάືࡢࣞ࣋ࣝࡶ༑ศ࡟㧗࠸ࠋ− 108 −ពぢ㸰 ᅜ㝿㐃ᦠ࡜ᗈሗࡣ༑ศ࡞ດຊࡀ࡞ࡉࢀ࡚࠸ࡿ࡜ᛮ࠸ࡲࡍࠋᅜ㝿㐃ᦠ࡛ࡣᮏ᮶ࠊࢺࢵࣉࢲ࢘
࡛ࣥࡣ࡞ࡃࠊ
ࠕ࣎ࢺ࣒࢔ࢵࣉᆺ࡛ࠖ࡞࠸࡜ᐇ㉁ⓗ࡛ࡣ࡞࠸࡜⚾ࡶᛮ࠸ࡲࡍࠋ
ࠕ࣎ࢺ࣒࢔ࢵࣉ
ᆺࠖ࡬ࡢ✚ᴟⓗ࡞ᨭ᥼ࡀ࠶ࡿࡇ࡜ࡣ⚽㐓࡜⪃࠼ࡲࡍࠋᅜ㝿Ꮫ⾡ᣐⅬࢆᮏᙜ࡟┠ᣦࡍࡢ࡛࠶
ࢀࡤࠊእᅜே◊✲⪅ࢆ༙ᩘ㸦࠶ࡿ࠸ࡣ 1/3㸧ࡃࡽ࠸࡟ࡋ࡚ࠊⱥㄒ࡛◊✲ᐊ㐠Ⴀ➼ࡀ࡛ࡁࡿࡇ࡜ࡀᚲ㡲࡜ᛮ࠸ࡲࡍࠋᅜ㝿໬ࡣ㸦Ꮫ㒊ࡢ࡞࠸኱Ꮫࡸ◊✲ᡤ࡛ࡢ㸧Ꮫ⏕⋓ᚓ࡜ࡶᐦ᥋࡟㛵ಀࡋ࡚ࡃࡿࡢ࡛ࠊᴟࡵ࡚㔜せ࡛ࡍ㸦ⱝᡭ⫱ᡂࡢ㡯ཧ↷㸧ࠋពぢ㸱 ᅜ㝿࢝ࣥࣇ࢓ࣞࣥࢫࡢ㛤ദࡸᅜ㝿ඹྠ◊✲ࡢ᥎㐍ࡣࠊ௒ᚋࡢᡤෆ◊✲ࡢⓎᒎ࡟㔜せ࡛࠶ࡿࠋ≉࡟ࠊ኱Ꮫ㝔⏕୺ദࡢ EMBL ࢩ࣏ࣥࢪ࣒࢘࡬ࡢ኱Ꮫ㝔⏕ࡢὴ㐵ࡣ⯆࿡῝࠸ࠋࡇࡢࡼ࠺࡞
௻⏬ࡣ᪥ᮏ࡛ࡶ⾜࠺࡭ࡁ࡛࠶ࡿࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡢⱝᡭ࠾ࡼࡧ኱Ꮫ㝔⏕ࡀ௻⏬ࡋ࡚ࠊ࠾ᐈࡉࢇ࡜ࡋ࡚࡛ࡣ࡞ࡃ୺ദ⪅ഃ࡜ࡋ࡚ᅜෆ࡟ᾏእ࠿ࡽࡢ኱Ꮫ㝔⏕ࢆᣍ⪸ࡋ࡚⾜࠺ࡇ࡜ࡀᐇ⌧ࡍࢀࡤࠊ᭦࡞ࡿ஺ὶ࡜Ⓨᒎࠊேᮦ⫱ᡂ࡟ከ኱࡞㈉⊩ࡀᮇᚅ࡛ࡁࡿࠋಶࠎࡢ◊✲ᐊ࡛ࣞ࣋ࣝࡢᅜ㝿ඹྠ◊✲ࢆࢥ࢔࡜ࡋࡓࠕ࣎ࢺ࣒࢔ࢵࣉᆺࠖᅜ㝿㐃ᦠࡣࠊᡤෆ◊✲ࡢάᛶ໬࡟᭷
ຠ࡛࠶ࡿ࡜⪃࠼ࡽࢀࠊ௒ᚋࡢᒎ㛤ࡀὀ┠ࡉࢀࡿࠋweb ࣐࢞ࢪࣥࠊFacebookࠊTwitter ➼ࡢ᪂ࡋ࠸፹య࡟ࡼࡿᗈሗࡣከࡃࡢ኱Ꮫ࡛ࡶྲྀࡾධࢀ࡚࠾ࡾࠊ㔜せ࡞ᗈሗ࣓ࢹ࢕࢔࡛࠶ࡿࠋ⌮⛉ᩍ⫱࡬ࡢ༠ຊࡣࠊḟୡ௦ࡢ◊✲⪅⫱ᡂࡢ♏࡜࡞ࡿࡶࡢ࡛࠶ࡿࠋឡ▱┴ෆࡢ㧗ᰯࡢࡳ࡛ࡢ
㛤ദ࡛ࡣࡣࡃࠊ᪥ᮏ඲ᅜつᶍ࡛⾜࠺࡭ࡁ࡛࠶ࡿࠋࡑࡢ㝿ࠊຓᩍࢡࣛࢫࡢⱝᡭ◊✲⪅ࢆὴ㐵ࡍࡿࡇ࡜ࡶ⪃࠼࡚࡯ࡋ࠸ࠋࡇࡢࡼ࠺࡞ᶵ఍ࡣࠊⱝᡭ◊✲⪅ഃ࡟࡜ࡗ࡚ࡶࠊ⮬㌟ࡢᡂ㛗࡜◊✲ࢆ⪃࠼ࡿୖ࡛㔜せ࡞ࡁࡗ࠿ࡅࢆ୚࠼ࠊ㧗ᰯ⏕ഃ࡟࠾࠸࡚ࡶ┠ᶆࢆ୚࠼ࡿ㈗㔜࡞ᶵ఍࡜࡞
ࡿ࡜⪃࠼ࡽࢀࡿࠋ
ពぢ㸲 ேဨ࠾ࡼࡧண⟬つᶍ࡛࠶ࡿሙྜࠊࡶࡋࠊᅜ㝿㐃ᦠࢆ┠ᣦࡍሙྜࠊࡶ࠺ᑡࡋάⓎ࡞ᅜ㝿஺ὶࡶḧࡋ࠸࡜ᛮࢃࢀࡿࠋ୍᪉ࠊSSH ᣦᐃᰯࡸࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࢫࢡ࣮ࣝ஦ᴗ࡛ࡢάື࡞
࡝⌮⛉ᩍ⫱࡬ࡢ༠ຊ࡛ࡣࠊ♫఍࡟ᐦ╔ࡋࡓࠊ≉Ⰽࡢ࠶ࡿᨭ᥼άື࡟ᛮࢃࢀព⩏῝࠸࡜ᛮࢃࢀࡿࠋ኱Ꮫ࡞࡝௚◊✲ᡤࡸᏛ఍࡛ࡢ✚ᴟⓗ࡞ㅮ₇ࡀࠊ୍⯡◊✲⪅࡬ࡢᇶ⏕◊ࡢ࢔ࣆ࣮ࣝ࡟࡞ࡿࡶ
ࡢ࡜ᛮࢃࢀࡿࠋ
web ࡸࠊface book ࡞࡝ࠊ኱Ꮫ⏕࡞࡝ⱝ࠸ୡ௦࡬ࡢᾐ㏱ࡣ㠀ᖖ࡟኱ࡁ࠸ࠋࡲࡓࠊࡇ࠺ࡋࡓ
ⱝ࠸ୡ௦ࡢᑗ᮶࡬ࡢព㆑ࡣࠊ᭱㏆ࡴࡋࢁ㧗ࡲࡗ࡚࠸ࡿ࡜ឤࡌࡽࢀࡿࡢ࡛ࠊಟኈㄢ⛬ࢆ┠ᣦࡍୡ௦⛬ᗘࡢᏛ⏕࡬ࡢ࢔ࣆ࣮ࣝࠊయ㦂ᐇ⩦ࡶࠊᇶ⏕◊ࡢᏑᅾࢆ▱ࡗ࡚ࡶࡽ࠺Ⰻ࠸ᶵ఍࡟࡞
ࡿ࡜ᛮࢃࢀࡿࠋ
㸦1㸧࡛ࡢࠊ㹙᪥ᮏࡢ◊✲࡟࠾ࡅࡿᖺ㱋ไ㝈᤼㝖㹛࡟ࡘ࠸࡚ࠊ࡜ࡢ㛵㐃࡛ࠊpositive ࡟ᖺ㱋࡟㛵ಀ࡞ࡃά㌍࡛ࡁࡿไᗘࢆࡶ࠺ࡅࠊⱝ࠸ generation ࡜ࡢ࣮࣎ࢲ࣮ࣇ࣮ࣜࡢయไࢆࡦ࠸
࡚ࠊᗈሗࡋ࡚࠸ࡃࡇ࡜ࢆ㐍ࡵ࡚࠸ࡓࡔࡅࢀࡤ࡜ᛮ࠺ࠋ✚ᴟⓗ࡟ࣞ࣋ࣝࡢ㧗࠸◊✲ࢆࡲࡍࡲࡍ᪸㐍ࡋ࡚࠸ࡃ࡜࠸࠺ࠊ◊✲ᡤ࡞ࡽ࡛ࡣࡢࠊࣘࢽ࣮ࢡ࡞యไࢆ☜❧ࡋࠊᗈࡃ࢔ࣆ࣮ࣝࡋ࡚
࠸ࡃࡇ࡜ࢆࠊ๓ྥࡁࡢጼໃ࡛ಁ㐍ࡋࡘࡘࠊάⓎ࡟⾜ࡗ࡚࠸ࡃ஦ࢆᥦゝࠊ☜❧ࡋࠊ㐍ࡵ࡚࠸ࡓࡔࡅࢀࡤ࡜ᛮ࠺ࠋ
ពぢ㸳 ᆅᇦ࡜ࡢ㐃ᦠࡣ㔜せࡔ࡜ᛮ࠸ࡲࡍࡢ࡛ࠊ⌧≧ࡢάືࢆ⥅⥆ࡍࡿࡇ࡜ࡣⰋ࠸࡜ᛮ࠸ࡲࡍࠋᚲ
ࡎࡋࡶᛂ⏝ⓗ࡛ࡣ࡞࠸◊✲ࡢ㔜せᛶࢆ୍⯡ᕷẸ࡟⌮ゎࡋ࡚ࡶࡽ࠸ࠊࡑࢀࢆᆅᇦࡢ㄂ࡾ࡜ࡋ
࡚ࡶࡽ࠼ࡿࡼ࠺࡟࡞ࡿࡇ࡜ࡀ㔜せࡔ࡜ᛮ࠸ࡲࡍࠋ

− 109 −ពぢ㸴 ᅜ㝿㐃ᦠ࡟㛵ࡋ࡚ࡣࠊ༑ศ࡟⾜ࢃࢀ࡚࠸ࡿࠋእᅜேᐈဨᩍᤵࠊእᅜேᐈဨ◊✲ဨไᗘࢆࡘ
ࡃࡾࠊ཮᪉ྥࡢ஺ὶࢆάᛶ໬ࡉࡏ࡚ࡣ࡝࠺࡛ࡋࡻ࠺ࠋ
ಶయ࠿ࡽ⩌㞟ࣞ࣋ࣝ◊✲ࡢᅜ㝿㐃ᦠࡶ᥎㐍ࡋ࡚㡬ࡁࡓ࠸ࠋᗈሗάື࡟㛵ࡋ࡚ࡶࠊ✚ᴟⓗ࡟⾜ࢃࢀ࡚࠸ࡿࠋ㧗ᰯࠊ୰Ꮫྥࡅࡢࢪࣗࢽ࢔ࢧ࢖࢚ࣥࢫㅮ⩏ࡣ⛉◊㈝ࠕࡦࡽࡵࡁ࡜ࡁࡵࡁࢧ࢖࢚ࣥࢫࠖ➼ࢆ฼⏝ࡋ࡚ࠊ඲ᅜ࡛ࣞ࣋ࣝᒎ㛤ࡍࡿ࡜Ⰻ࠸ࠋ

㸲㸧᪂㡿ᇦࡢ㛤ᣅ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
᪂ࡋ࠸◊✲㡿ᇦࡢ㛤ᣅࢆ┠ᣦࡋ࡚ࠊ⏕≀ࡢ⎔ቃ㐺ᛂᡓ␎࡜ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ࡟ὀ┠ࡋ࡚◊✲άືࢆ⾜࠸ࡲࡋࡓࠋ⎔ቃᛂ⟅◊✲ࢆ᥎㐍ࡍࡿࡓࡵࠊᏘ⠇⏕≀Ꮫᐈဨ◊✲㒊㛛ࢆ᪂タࡋࡲࡋࡓࠋࣂ࢖
࢜࢖࣓࣮ࢪࣥࢢ࡛ࡣ⮬↛⛉Ꮫ◊✲ᶵᵓࡢศ㔝㛫㐃ᦠ◊✲ㄢ㢟࡜ࡋ⿵ൾගᏛ⣔ࡢ㢧ᚤ㙾࡬ࡢᛂ⏝ࢆࡍࡍࡵࡲࡋࡓࠋᇶ♏⏕≀Ꮫศ㔝࡛௒ᚋⓎᒎࡀᮇᚅࡉࢀࡿศ㔝࡛ࡢ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕ᙧᡂࢆ┠ᣦࡋ࡚㛤ദࡋ࡚࠸ࡿ⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦OBC㸧࡟ࡘ࠸࡚ࡣࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡜
ࡢᰂ㌾࡞౑࠸ศࡅࡀ࡛ࡁࡿ௙⤌ࡳࢆ┠ᣦࡋ࡚ᡤෆࡢ㆟ㄽࢆ⾜࠸ࡲࡋࡓࠋຍ࠼࡚ࠊ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࢆタ⨨ࡋࡲࡋࡓࠋ㈨ᩱ㸯࡟ࡲ࡜ࡵࡓࡇࢀࡽࡢάື࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋ
ࡲࡓ௒ᚋࠊ᪂㡿ᇦࡢ㛤ᣅ࡟㛵ࡋ࡚ᇶ⏕◊ࡀ࡝ࡢࡼ࠺࡞ᙺ๭ࢆᯝࡓࡍ࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋ
ࡓࡽ࠾⪺࠿ࡏୗࡉ࠸ࠋ
ពぢ㸯 ᇶ♏⏕≀Ꮫ◊✲ᡤࡣᡃࡀᅜࡢᇶ♏⏕≀Ꮫࢆ࣮ࣜࢻࡋ࡚࠸ࡃ౑࿨ࢆ᭷ࡋ࡚࠸ࡿࡀࠊ⎔ቃᛂ⟅◊✲࡞࡝ࡣࡑࡢࡼ࠺࡞᪂ࡋ࠸◊✲ࡢ᪉ྥᛶࢆᶍ⣴ࡍࡿヨࡳ࡜ࡋ࡚኱ኚ᭷ຠ࡛࠶ࡿࠋ⎔ቃࡀ⏕≀࡟࡝ࡢࡼ࠺࡞ᙳ㡪ࢆཬࡰࡋ࡚࠸ࡃ࠿࡜࠸࠺㛗ᮇⓗ࡞どⅬࡢ◊✲ࡣࠊ኱ኚ㔜せᛶࡀ㧗ࡃ࡞ࡗ࡚࠸ࡃࡶࡢ࡜⪃࠼ࡽࢀࡿࠋ᪂ࡓ࡟ྜྷᮧᐈဨᩍᤵࢆᣍࡁධࢀࡿ࡞࡝యไྡ࡛ࡢ඘ᐇࡶ⾜ࡗ࡚࠾ࡾࠊ௒ᚋࡢᒎ㛤ࡀᮇᚅ࡛ࡁࡿࠋࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࡣࡶ࡜ࡶ࡜ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᙉࡳ࡛ࡶ࠶ࡿࡀࠊࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫ࡞࡝ࡢᬑཬάືࡸᅜෆࡢ◊✲ᶵ㛵ࡢࢿࢵࢺ࣮࣡ࢡᙧ
ᡂࢆࡣ࠿ࡿࡇ࡜୍࡛ᒙࡢⓎᒎࡀᮇᚅ࡛ࡁࡿࠋ⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦OBC㸧࡟ࡣࠊᑠつᶍࡢ⡿ᅜࢦ࣮ࢻࣥ఍㆟ࡢࡼ࠺࡞ᙺ๭ࢆᮇᚅࡋ࡚࠸ࡿࡀࠊண⟬๐ῶࡢᙳ㡪ࡶ࠶ࡾࠊNIBB ࢥࣥࣇ࢓ࣞࣥࢫ࡜❧ࡕ఩⨨ࡀఝ࡚ࡁ࡚ࡋࡲࡗ࡚࠸ࡿࠋ⌧ᅾࡢ᪉㔪࡛࠶ࡿᰂ㌾࡞㐠⏝ࡣ⌧ᐇⓗ࡞㑅ᢥ⫥࡛࠶ࡿࡀࠊ࡛ࡁࢀࡤᨻᗓ࡞࡝ࡢண⟬ᥐ⨨࡟ࡼࡗ࡚ OBC ࡢᣑ඘ࢆᅗࡾࠊ
ᮏ᮶ࡢጼࢆ᚟άࡋ࡚ḧࡋ࠸࡜ᛮ࠺ࠋ
ពぢ㸰 ᪂㡿ᇦࡢ㛤ᣅࡣࠊᇶ♏ⓗ࡞◊✲ࢆ➨୍࡜ࡍࡿ◊✲ᶵ㛵ࡢ౑࿨࡜⪃࠼ࡲࡍࠋ⌮᝿ⓗ࡟ࡣࠊᑡ࡞ࡃ࡜ࡶ 20-30 ᖺඛࠊᡈ࠸ࡣ 50 ᖺ௨ୖඛࢆぢᤣ࠼ࡓ◊✲ࡀ⢔ࠎ࡜⾜ࢃࢀࡿࡇ࡜ࢆᮇᚅࡋ
ࡲࡍࠋࡑࡢព࿡࡛ࡣࠊ⎔ቃ㐺ᛂࡶ࢖࣓࣮ࢪࣥࢢࡶ࠿࡞ࡾ㏆ど║ⓗ࡛ࠊ᫬ὶ࡟ࡣ஌ࡗ࡚ཎ㈨ࢆ㞟ࡵ᫆࠸࠿ࡶ▱ࢀࡲࡏࢇࡀࠊࠕ᪂㡿ᇦࡢ㛤ᣅࠖ࡜ࡋ࡚ࡢ࢖ࣥࣃࢡࢺࡣᙉࡃ࡞࠸࡜ឤࡌࡲ
ࡍࠋOBC ࡢࡼ࠺࡞఍ྜࡣࡶ࡜ࡶ࡜ᐃᮇ໬ࡍࡿࡶ࡛ࡣ࡞࠸࡜ᛮ࠸ࡲࡍࠋᐃᮇ໬ࡍࡿ࡜ࠊࡍ
ࡄ࡟㣬࿴ࡋ࡚ࡋࡲ࠸ࡲࡍࠋ᪂つ◊✲ࢸ࣮࣐Ⓨ᥀ࡣ࢔࢖ࢹ࢔ḟ➨࡛ࡍࡢ࡛ࠊᛮ࠸ࡘ࠸ࡓࡾࠊ
Ẽ㐠ࡀ㧗ࡲࡗࡓ᫬࡟㛤ദࡍࢀࡤ࠸࠸࡜ᛮ࠸ࡲࡍࠋ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࡣࠊᚑ᮶ࡢ
ࣔࢹࣝ⏕≀࡛ࡣ◊✲ࢆ⾜࠺ࡇ࡜ࡀᅔ㞴࡞⏕࿨⌧㇟࡟ࡘ࠸࡚ࡶࡗ࡜࢔ࣆ࣮ࣝࡍࡿ࡜ࠊࡑࡢ㔜せᛶࡀࢃ࠿ࡾ᫆࠸࠿ࡶ▱ࢀࡲࡏࢇࠋ

− 110 −ពぢ㸱 ⎔ቃ㐺ᛂᡓ␎࡛ࡣࠊࢤࣀ࣒⛉Ꮫࢆᇶ┙࡜ࡋ࡚ࠊከᵝ࡞ࣔࢹࣝ⏕≀ࢆ◊✲ᑐ㇟࡜ࡋ࡚⥙⨶ⓗ࡞ゎᯒ࡜⌮ㄽ◊✲ࢆ⼥ྜࡋࡓ᪂ࡓ࡞◊✲ศ㔝ࡢ๰ᡂࢆ┠ᣦࡋࡓࠋ᳜≀࡜ື≀ࡢࡑࢀࡒࢀ࡟
ࡘ࠸࡚ࠊ⏕యእ⎔ቃᛂ⟅࡜⏕యෆ⎔ቃᛂ⟅࡬ࡢ࣓࢝ࢽࢬ࣒ࢆ┠ᣦࡋࡓ◊✲ࡀ⾜ࢃࢀࡓࠋࣂ
࢖࢜࢖࣓࣮ࢪࣥࢢ࡛ࡣࠊඛᑟࡍࡿ㢧ᚤ㙾ᢏ⾡ࡢ㛤Ⓨ࡜ᡭἲࡢᬑཬࢆ᥎㐍ࡋࡓࠋḟୡ௦ࡢ
DSLM ࡸ IR-LEGO ࡜࠸ࡗࡓ㢧ᚤ㙾ࢩࢫࢸ࣒ࢆࠊ30 ௳ࡢඹྠ◊✲࡟౑⏝ࡋࡓࡇ࡜ࡣࠊ᪂
ࡓ࡞ᢏ⾡ࡢᬑཬ࡜ゎᯒᢏ⾡ࡢ࣮࣋ࢫ࢔ࢵࣉ࡟㈉⊩ࡍࡿ࡜⪃࠼ࡽࢀࡿࠋࡇࢀࡽࢆ౑⏝ࡍࡿ࡟࠶ࡓࡾࠊࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࡢ㛤ദࡣ㔜せ࡛࠶ࡿ࡜⪃࠼ࡿࠋṇࡋ࠸ࢹ࣮ࢱྲྀᚓἲࡸࢹ࣮ࢱ
ࡢゎ㔘ࢆᣦᑟࡍࡿࡇ࡜ࡣࠊ᪂ࡓ࡞ᢏ⾡ࡢᬑཬ࡜୪⾜ࡋ࡚⾜࠺ࡇ࡜ࡀᚲ㡲࡛࠶ࡿࠋពぢ㸲 ࣂ࢖࢜࢖࣓࣮ࢪࣥࢢ㡿ᇦࡢ㛤Ⓨࢆྵࡵࠊ⏕≀ࡀ⎔ቃ࡟㐺ᛂࡋࡓ᫬ࡢ㑇ఏᏊࡸ⣽⬊ࡢᶵ⬟ࡢ⋓ᚓࠊ࡞࡝ᵝࠎ࡞᪂㡿ᇦࡢ㛤Ⓨࡀ┠ᣦࡉࢀ࡚࠸ࡿࠋࡑࡢ୰࡛ࠊ⎔ቃ㐺ᛂᡓ␎ࠊ᪂つࣔࢹࣝ⏕≀㛤Ⓨࢭࣥࢱ࣮ࡢάືࡣࠊ௚࡟ࡣ࡞ࡃࠊᇶ⏕◊ࡀ࣮ࣜࢲ࣮ࢩࢵࣉࢆྲྀࡿࡇ࡜ࡀᮇᚅࡉࢀ
࡚࠸ࡿ㡿ᇦ࡜ᛮࢃࢀࡿࠋ✚ᴟⓗ࡞࣮ࣜࢲ࣮ࢩࢵࣉࡀᮇᚅࡉࢀࡿࠋ
ᅜෆእࡢ௚ࡢ◊✲ᡤ࡜ࡢ㐃ᦠࡸ᪂ࡋ࠸ࣉࣟࢪ࢙ࢡࢺࡢ❧ࡕୖࡆࢆࡶྵࡵࡓ✚ᴟⓗ࡞ไᗘࢆྲྀࡾධࢀࡿ஦ࡀᮃࡲࢀࡿࠋ
ពぢ㸳 ᇶ⏕◊ࡢ≉ᚩࡀฟ࡚࠸ࡿࡼ࠸ྲྀࡾ⤌ࡳࡔ࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸴 ᪂㡿ᇦࡢ㛤ᣅ࡟㛵ࡍࡿάືࡣ✚ᴟⓗ࡟⾜ࢃࢀ࡚ࡁ࡚࠸ࡿࠋ௒ᚋࢆぢᤣ࠼ࢀࡤࠊ⏕ែ⣔ࡢከᵝᛶࡢ⥔ᣢᶵᵓࢆ࣑ࢡࣟ࠿ࡽ࣐ࢡࣟࡲ࡛⼥ྜࡋ࡚◊✲ࡍࡿ᪂㡿ᇦࡢ㛤ᣅ࡟ࡶྲྀࡾ⤌ࢇ࡛࡯ࡋ࠸ࠋ㸳㸧ⱝᡭ◊✲⪅ࡢ⫱ᡂ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
⥲ྜ◊✲኱Ꮫ㝔኱Ꮫࡢᇶ♏⏕≀Ꮫᑓᨷࡢᇶ┙ᶵ㛵࡜ࡋ࡚኱Ꮫ㝔⏕ᩍ⫱ࢆᐇ᪋ࡋࡓ௚ࠊྡྂᒇ኱Ꮫ
ࡢ࣮ࣜࢹ࢕ࣥࢢ኱Ꮫ㝔ࣉࣟࢢ࣒ࣛ࡜ࡢ㐃ᦠάືࡸࠊྡྂᒇᕤᴗ኱Ꮫ࡜ᩍ⫱࣭◊✲࡟㛵ࡍࡿ㐃ᦠ༠ᐃࢆ⥾⤖ࡍࡿ࡞࡝ࠊከᵝ࡞ヨࡳࢆᐇ᪋ࡋࡲࡋࡓࠋࡲࡓࠊᅜෆࠊᅜእ࠿ࡽࡢ኱Ꮫ㝔⏕☜ಖ࡟ດࡵࡲ
ࡋࡓࠋ㈨ᩱ㸯࡟ࡲ࡜ࡵࡓࡇࢀࡽࡢάື࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋࡲࡓ௒ᚋࠊⱝᡭ◊✲⪅ࡢ⫱ᡂ࡟㛵ࡋ࡚ᇶ⏕◊ࡀ࡝ࡢࡼ࠺࡞ᙺ๭ࢆᯝࡓࡍ࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋࡓࡽ࠾⪺࠿ࡏୗࡉ࠸ࠋពぢ㸯 ኱Ꮫ㝔ᩍ⫱ࡣ࡝ࡢ኱Ꮫࡶ㞴ࡋ࠸᫬௦ࢆ㏄࠼࡚࠸ࡿࠋ≉࡟༤ኈㄢ⛬ࡢᏛ⏕ࡢῶᑡഴྥࡣ㢧ⴭ
࡛࠶ࡿࠋRA ࡸ࣮ࣜࢹ࢕ࣥࢢ኱Ꮫ㝔࡞࡝ࡢࢧ࣏࣮ࢺయไࡢᣑ඘࡟ຍ࠼ࠊ࢟ࣕࣜ࢔ࢹࢨ࢖ࣥ
ࡢ᪉ྥᛶࢆᏛ⏕࡟ᥦ♧࡛ࡁࡿࡋࡃࡳࡀ࠶ࡿࡇ࡜ࡀ኱ษ࡛࠶ࢁ࠺ࠋᏛ⏕ࡢࣜࢡ࣮ࣝࢸ࢕ࣥࢢ
࡟㛵ࡋ࡚ࡣࠊᅜෆእࡢ኱Ꮫ࣭◊✲ᶵ㛵࡬ࡢᗈሗάື㸦య㦂ධᏛ࣭࣏ࢫࢱ࣮࡞࡝㸧ࡣࡋࡗ࠿ࡾ࡜⾜ࢃࢀ࡚࠸ࡿ࡜ᛮ࠺ࠋ」ᩘᩍဨ࡟ࡼࡿᣦᑟయไࡶࠊḢ⡿ࡢ኱Ꮫ㝔࡟ぢࡽࢀࡿࢩࢫࢸ࣒
࡛࠶ࡾࠊ௒ᚋࡢ୺ὶ࡜࡞ࡗ࡚ࡃࡿ᪋⟇࡜ᛮࢃࢀࡿࠋ௒ᚋࡣ኱Ꮫ㝔⏕ࡢ㉁࡜㔞ࢆ࡝ࡢࡼ࠺࡟
ྥୖࡍࡿ࠿ࡀ㘽࡜࡞ࡿࡀࠊ࡝ࡢ኱ᏛࡶࡇࡢⅬ࡟ࡣⱞປࡋ࡚࠸ࡿࡇ࡜࡛ࡶ࠶ࡿࠋ≉ຠ⸆࡜ゝ࠼ࡿ᪉ἲࡣ⌧᫬Ⅼ࡛ࡣ࡞࠸ࡀࠊ௒ᚋࡢ㔜せ࡞ㄢ㢟࡜ࡋ࡚ᘬࡁ⥆ࡁ᳨ウࡋ࡚ḧࡋ࠸ࠋពぢ㸰 Ꮫ㒊ࡢ࡞࠸ᶵ㛵ࡀඃ⚽࡞Ꮫ⏕ࢆ㞟ࡵࡿࡢࡣ⮳㞴ࡢᴗ࡛ࡍࠋ኱Ꮫ࡜ࡢ㐃ᦠࡶࠊ᪂ࡓ࡞ᑓᨷ㸦ᡈ− 111 −

࠸ࡣ◊✲⛉㸧ࢆసࡿࡃࡽ࠸ࡢᐦ࡞㐃ᦠ࡛࡞ࡅࢀࡤࠊ኱Ꮫ㝔⏕☜ಖ࡜ࡋ࡚వࡾຠᯝࡣ࡞࠸࡛
ࡋࡻ࠺ࠋᅜ㝿໬ࢆ㐍ࡵ࡚ࠊඃ⚽࡞␃Ꮫ⏕ࢆ⋓ᚓࡍࡿࡢࡀ⌧ᐇⓗࡔ࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸱 ㏆㞄ࡢ኱Ꮫ࡜ࡢᥦᦠࡸࠊ኱Ꮫ㝔⏕ࡢཷࡅධࢀࡣ✚ᴟⓗ࡟⾜࠺࡭ࡁ࡜⪃࠼ࡿࠋඃ⚽࡞◊✲⪅࡜⫱ᡂࡍࡿࡓࡵ࡟ࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢேⓗ࠾ࡼࡧ≀㉁ⓗ㈨※ࢆ฼⏝ࡍࡿࡇ࡜ࡣࠊᡃࡀᅜ
ࡢ◊✲Ỉ‽ྥୖ࡟ࡶᙺ❧ࡘࠋ኱Ꮫ㝔⏕ࡢᣑ඘ࡢࡓࡵ࡟ࡣࠊᏛ⏕࡟࡜ࡗ࡚㨩ຊ࠶ࡿ࢖ࣥࢭࣥ
ࢸ࢕ࣈࢆ⪃࠼ࡿᚲせࡣ࠶ࡿࡢ࠿ࡶ▱ࢀ࡞࠸ࠋࡲࡓࠊ⌧ᅾࠊᅜ❧኱Ꮫࢆ୰ᚰ࡟㐃ᦠࢆ⾜ࡗ࡚࠸ࡿࡼ࠺࡟ぢ࠼ࡿࡀࠊྡᇛ኱Ꮫࠊឡ▱ᕤᴗ኱Ꮫࠊ༡ᒣ኱Ꮫࠊ୰㒊኱Ꮫ࡞࡝ࡢ㏆㞄ࡢ⌮⣔Ꮫ㒊Ꮫ⏕ࡶᑐ㇟࡜ࡋ࡚ࠊᇶ♏ⓗ࡞㒊ศ࠿ࡽ᰿Ẽࡼࡃ◊✲⪅ࢆ⫱࡚ࡿ࡜࠸࠺ࡇ࡜ࡶ⪃࠼࡚ࡶⰋ࠸ࡢ࠿ࡶ▱ࢀ࡞࠸ࠋ₯ᅾⓗ࡟ඃ⚽࡞ⱝᡭࢆⓎ᥀ࡍࡿࡇ࡜ࡶࠊ௒ᚋࡣ㔜せ࡛࠶ࡿࠋពぢ㸲 ⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ࣭ᇶ♏⏕≀Ꮫᑓᨷᇶ┙ჾᐁ࡜ࡋ࡚ࡢ኱Ꮫ㝔⏕ᩍ⫱ࡸ௚኱Ꮫ࡜ࡢ㐃ᦠ࡟ࡼࡿᏛእㅮ⩏ࡢᐇ᪋ࠊእᅜ࠿ࡽࡢ␃Ꮫ⏕ࡢཷࡅධࢀ➼ࠊⱝᡭ◊✲⪅ࡢ㣴ᡂ࡟ࡶດࡵ࡚࠸ࡿࠋ
኱Ꮫ㝔⏕ࡸⱝᡭ◊✲⪅ࡢ㑅ᢥ⫥ࡀቑ࠼ࡿ࡜࠸࠺Ⅼ࡞࡝ࠊ᭷┈࡜ᛮࢃࢀࡿࠋ⥲ྜ◊✲኱Ꮫ㝔
኱Ꮫฟ㌟⪅࡛ά㌍ࡍࡿ◊✲⪅ࡶከࡃ࠾ࡽࢀࠊᩍ⫱ᶵ㛵࡜ࡋ࡚ࡶᐇ⦼ࡀ࠶ࡾࠊホ౯࡛ࡁࡿࠋ

␗ศ㔝ࡢ◊✲⪅ࠊ≉࡟ࠊᇶ♏◊✲ࢆ㔜どࡍࡿ◊✲⪅ࡀࠊ୍ᇽ࡟఍ࡋ࡚࠸ࡿ࡜࠸࠺ࠊ௚ࡢ◊✲ᶵ㛵࡟ࡣ࡞࠸Ⅼࢆࡉࡽ࡟ఙࡤࡋࠊᛂ⏝ࢆ┤㏆ࡢ┠ᶆ࡜ࡣࡋ࡞࠸ࠊⱝᡭ◊✲⪅ࡢ⣧⢋࡞⯆࿡ࢆఙࡤࡋࠊ⫱࡚ࡿᶵ㛵࡛࠶ࡗ࡚࡯ࡋ࠸࡜ᛮ࠸ࡲࡍࠋ

ពぢ㸳 ᇶ⏕◊࡜ࡋ࡚ࠊ኱Ꮫ㝔⏕➼࡟࡝ࡢࡼ࠺࡞㸦᭱ప㝈ࡢ㸧೔⌮ᩍ⫱ࢆࡋ࡚࠸ࡿ࠿ࢆ௒ᚋࡣእ㒊࡟බ⾲ࡋࡓ࡯࠺ࡀࡼ࠸᫬௦࡟࡞ࡗ࡚ࡃࡿ࠿ࡶࡋࢀࡲࡏࢇࠋ
ពぢ㸴 ኱Ꮫ㝔⏕ࡢᩍ⫱࡟㛵ࡋ࡚ࡣࠊດຊࡉࢀ࡚࠾ࡾࠊ⌧≧࡛༑ศ࡜ุ᩿ࡋࡲࡍࠋ࣏ࢫࢻࢡ㞠⏝ࡢண⟬ࢆቑࡸࡍ࡞࡝ࡋ࡚ࠊ᭱ඛ➃◊✲⤒㦂ࡢ㛛ᡞࢆ࣏ࢫࢻࢡࡽ࡟ࡉࡽ࡟ᗈࡆ࡚㡬ࡁࡓ࠸ࠋ㸴㸧ᑗ᮶ィ⏬㸦ᖹᡂ㸰㸳ᖺᗘᴫ⟬せồ㸧࡟ࡘ࠸࡚ᇶ♏⏕≀Ꮫ◊✲ᡤࡣࠊ᪥ᮏᏛ⾡఍㆟ࠕᏛ⾡ࡢ኱ᆺ᪋タィ⏬࣭኱つᶍ◊✲ィ⏬ࠖ࡜ࡋ࡚ࠕ⏕≀ࡢ⎔ቃ㐺ᛂᡓ␎ゎ᫂ࡢࡓࡵࡢ኱Ꮫ㐃ᦠ◊✲ᣐⅬࢿࢵࢺ࣮࣡ࢡࡢᙧᡂࠖࢆ┠ᣦࡍ኱つᶍࣉࣟࢪ࢙ࢡࢺࢆ
⏦ㄳࡋ࡚࠾ࡾࠊࡇࡢࣉࣟࢪ࢙ࢡࢺࢆᨭ࠼ࡿ  ࡘࡢᰕ࡜ࡑࡢᇶ┙タഛᩚഛࢆ┠ᣦࡋࡓᴫ⟬せồࢆ㐍ࡵࠊ㈨ᩱ㸯࡟ࡲ࡜ࡵࡓࡼ࠺࡟ᴫ⟬せồࡸ⿵ṇண⟬࡜ࡋ࡚ᐇ᪋ࡀㄆࡵࡽࢀ࡚࠸ࡲࡍࠋࡇࢀࡽࡢィ⏬
࡟ࡘ࠸࡚ࡈពぢࢆ࠾⪺࠿ࡏୗࡉ࠸ࠋࡲࡓ௒ᚋࠊᇶ⏕◊ࡀ◊✲ᣐⅬ࡜ࡋ࡚࡝ࡢࡼ࠺࡞ᙺ๭ࢆᯝࡓࡍ
࡭ࡁ࠿ࠊࡈពぢࡀࡈࡊ࠸ࡲࡋࡓࡽ࠾⪺࠿ࡏୗࡉ࠸ࠋ
ពぢ㸯 ࠕࣔࢹࣝ⏕≀ࢆ⏝࠸ࡓ⎔ቃ㐺ᛂᡓ␎ࡢゎ᫂ࢆ┠ᣦࡍḟୡ௦ࢤࣀ࣒◊✲ࠖࠕ᪂つࣔࢹࣝ⏕≀ࡢ㛤ⓎᣐⅬᙧᡂࠖ࡟ࡘ࠸࡚ࡣࠊ⌧௦ⓗ࡞ࢸ࣮࣐࡛ၥ㢟ࡣ࡞࠸࡜ᛮ࠺ࠋࡓࡔࡋࠊ⡿ᅜ NSF
࡛ࡣࠊḟୡ௦ࢩ࣮ࢡ࢚ࣥࢧ࣮ࡸ CRISPER/Cas9 ࡢⓏሙ࡞࡝࡛ࠊࠕ㠀ࣔࢹࣝ⏕≀ࠖ◊✲࡬ࡢᨭ᥼ࡀᙉ໬ࡉࢀ࡚࠸ࡿ࡜ࡢヰࢆ⪺࠸࡚࠸ࡿࠋࡇࡢࡼ࠺࡞ほⅬ࠿ࡽࠊ≉ᐃࡢࠕࣔࢹࣝ⏕≀ࠖ࡟㝈ᐃࡉࢀࡿࡼ࠺࡟ぢ࠼ࡿ㢟┠࡛ࡣ࡞ࡃࠊࠕ㠀ࣔࢹࣝ⏕≀ࠖࢆᑐ㇟࡟᪂ࡓ࡞ཎ⌮ࡸ⌧㇟ࡢゎ᫂ࢆ┠ᣦࡍ᪉㔪ࡀ᫂☜࡟ࢃ࠿ࡿࡼ࠺࡟㢟┠タᐃࢆࡋࡓ᪉ࡀࠊ௒ᚋࡢᇶ♏⏕≀Ꮫ◊✲ᡤࡢ
Ⓨᒎ࡟㈨ࡍࡿࡼ࠺࡟ឤࡌࡓࠋ

− 112 −

ࠕከඖⓗ⏕≀᝟ሗࡢ⤫ྜゎᯒࢩࢫࢸ࣒ࠖࡶࠊ᫬✵㛫᝟ሗࡢ᝟ሗゎᯒ࡜࠸࠺⌧௦ⓗ࡞ࢸ࣮࣐࡛࠶ࡾࠊ௒ᚋ࡟ᮇᚅࡀ࡛ࡁࡿࠋ⌧᫬Ⅼ࡛ࡣࣜࢯ࣮ࢫࡢ㛵ಀ࡛ከࡃࡢ◊✲⪅ࡢཧ⏬ࡀ㞴ࡋ࠸ࡢ࠿࡜ࡶᛮ࠺ࡀࠊᑡ࡞ࡃ࡜ࡶࡶ࠺ᑡࡋࡇࢀࡽࡢࣉࣟࢪ࢙ࢡࢺࡢࣅࢪࣅࣜࢸ࢕࣮ࢆྥୖࡋࠊ
ࡼࡾከࡃࡢ◊✲⪅ࡀㄆ▱ࢆಁࡋ࡚ࠊ᝟ሗࡢࢿࢵࢺ࣮࣡ࢡ໬ࢆᅗࡿᕤኵࡀ࠶ࡗ࡚ࡶⰋ࠸࡜ឤ
ࡌࡓࠋዪᛶ◊✲⪅ࡀᑡ࡞࠸࡜࠸࠺ၥ㢟Ⅼ࡟ࡘ࠸࡚ࡣࠊ෸ᩍᤵࡢ᥇⏝࡞࡝ࠊ௒ᚋࡢ᥇⏝࡛ᚎࠎ࡟ゎỴࡉࢀ࡚࠸ࡃ࡜ᮇᚅࡋ࡚࠸ࡿࠋ

᭱ᚋ࡟ࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡣᇶ♏⏕≀Ꮫࢆᐇ㊶ࡍࡿ㠀ᖖ࡟㔜せ࡞◊✲ᶵ㛵࡛࠶ࡾࠊࡑࡢ≉ู࡞౑࿨ࢆㄆ㆑ࡋ࡚◊✲࡟㑌㐍ࡋ࡚ḧࡋ࠸ࠋពぢ㸰 ᫬ὶࢆㄞࡳ࡞ࡀࡽࠊ⌧ᐇ㊰⥺࡛ࡢィ⏬ࢆ❧࡚ࡿᚲせࡣ࠶ࡿࡢ࡛ࡍࡀࠊ୍᪉࡛ࠊ◊✲ᡤࡢᏑᅾព⩏ࢆ⪃࠼ࡿ࡜ࠊ௚ᶵ㛵ࠊ≉࡟኱Ꮫ࠿ࡽࡣฟ࡚ࡁࡑ࠺࡟࡞࠸ࠊᑡࠎ㣕⩧ࡋ㐣ࡂࡃࡽ࠸ࡢ
ࠕክࡢ࠶ࡿࠖ࢔࢝ࢹ࣑ࢵࢡ࡞ィ⏬ࢆ୍ࡘࡄࡽ࠸୺ᙇࡍࡿࠊ୺ᙇࡋ⥆ࡅࡿࡇ࡜ࡶࠊ᱌እ㔜せ࡞ࡇ࡜ࡔ࡜ᛮࡗ࡚࠸ࡲࡍࠋ⌧ᐇ㊰⥺࡜ࡋ࡚㸪ᮏᏛ⾡఍㆟ࠕᏛ⾡ࡢ኱ᆺ᪋タィ⏬࣭኱つᶍ◊✲ィ⏬ࠖࡣࠊ௒ᚋࡢືྥࢆὀどࡋࡓ࠸࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸱 ᇶ♏⏕≀Ꮫࡢ᪂ࡓ࡞ᒎ㛤ࡢࡓࡵ࡟ࡣࠊ᪂つࣔࢹࣝ⏕≀ࡢ㛤Ⓨࡣ㔜せ࡛࠶ࡿࠋࢤࣀ࣒ゎㄞ࡜㑇ఏᏊ᧯స⣔ࢆ☜❧ࡋࠊከࡃࡢ⏕≀࡛ಖᏑࡉࢀࡓ⏕࿨⌧㇟ࢆᾋࡁ᙮ࡾ࡟࡛ࡁࡿࣔࢹࣝ⏕≀ࢆࠊከᩘ㛤Ⓨࡍࡿࡇ࡜ࡀ࡛ࡁࢀࡤࠊ௒ᚋࡢ⇿Ⓨⓗ࡞◊✲ࡢⓎᒎࡀಖドࡉࢀࡿࠋࣂ࢖࢜ࣂࢵ
ࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ࡛ࠊ᪂ࡓ࡞ࣔࢹࣝ⏕≀ࡢಖᏑ࡜⥔ᣢࡣᢸಖ࡛ࡁࡿࡢ࡛ࠊࡇࢀࡽࡢ㸱ࡘࡢᰕࡣ࡜࡚ࡶⰋ࠸ᵓᡂ࡟࡞ࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡿࠋᇶ⏕◊ࡀࠊࣔࢹࣝ⏕≀㛤Ⓨࡢ◊✲ᣐⅬ࡜ࡋ࡚ᅜෆ࡛఩⨨࡙ࡅࡽࢀࡿࡼ࠺࡞ᙺ๭ࢆᯝࡓࡍࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ
ពぢ㸲 」ᩘࡢࣉࣟࢪ࢙ࢡࢺࡀቑ㢠ண⟬ࡸ᥇ᢥ࡟࡞ࡗ࡚࠸ࡿࠋ୺࡟ࠊ⎔ቃ࡜⏕≀࡟࠿࠿ࢃࡿࡶࡢ࡛
࠶ࡾࠊᇶ⏕◊ࡢ◊✲ᣦ㔪࡜୍⮴ࡋࡓ᪉ྥࢆྥ࠸ࡓ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋࡲࡓࠊ⏕≀㑇ఏ㈨※ࡢಖᏑ࣭⟶⌮ᇶ┙Ⓨᒎࡢࡼ࠺࡟ᐇ⏝ⓗ࡞ࣉࣟࢪ࢙ࢡࢺ࡟ຍ࠼ࠊ᪂つࣔࢹࣝ⏕≀ࡢ㛤Ⓨ
ᣐⅬࣉࣟࢪ࢙ࢡࢺࡢࡼ࠺࡞ᇶ⏕◊ࡔ࠿ࡽࡇࡑ࡜࠸࠺ࣉࣟࢪ࢙ࢡࢺࡶ࠶ࡾࠊᑗ᮶ࡢⓎᒎࡀᮇᚅࡉࢀࡿࠋ኱Ꮫࡸ⌮◊࡞࡝ࡢ௚ࡢ◊✲ᶵ㛵࡜ࡢ㐪࠸ࢆ᫂░࡟࢔ࣆ࣮࡛ࣝࡁࡿⅬࢆఙࡤࡍ᪉
㔪ࡶ኱ษ࡟ᛮࢃࢀࡿࠋ
୍᪉࡛ࠊࡇ࠺ࡋࡓࣉࣟࢪ࢙ࢡࢺࢆᇶ⏕◊ࡀ୺ᑟࡋ࡚࠸ࡿ࡜࠸࠺ࠊᅜෆእࡢ◊✲⪅࡬ࡢ࢔ࣆ࣮ࣝ㸦౛࠼ࡤࠊ኱Ꮫ࡛ࡢㄝ᫂఍࡞࡝㸧ࡀࡶ࠺ᑡࡋ࠶ࡿ࡜Ⰻ࠸ࡼ࠺࡟ᛮࢃࢀࡿࠋ

ពぢ㸳 ࠸ࡎࢀࡶᇶ⏕◊ࡀᢸ࠺࡭ࡁࣉࣟࢪ࢙ࢡࢺ࡛࠶ࡾࠊ㐺ษࡔ࡜ᛮ࠸ࡲࡍࠋ
ពぢ㸴 ⎔ቃ࡜ࢤࣀ࣒࡜ࡢ┦㛵ࡀ㔜せ࡞ࡢࡣศ࠿ࡿࠋ㠀⏕≀ⓗ࡞⎔ቃせᅉ㸦ᗘࠊ‵ᗘࠊ᪥㛗➼㸧ࡔࡅ࡛࡞ࡃࠊ⏕≀ⓗ࡞⎔ቃせᅉ㸦⏕≀㛫┦஫స⏝㸧ࡶ⏕≀ࡢከᵝᛶࢆࡶࡓࡽࡍࡢ࡛ࠊ⏕≀⎔ቃ㐺ᛂᡓ␎ࢆ◊✲ࡍࡿ࡞ࡽࠊᙜ↛⏕ែᏛⓗ࡞どⅬࡀᚲせ࡛࠶ࢁ࠺ࠋ⏕≀ከᵝᛶ࡟㛵ࡋ࡚
ࡣࠊLTER㸦Long Term Ecological Research㸧ࡢ࣐ࢫࢱ࣮ࣉࣛࣥࡶฟ࡚࠾ࡾࠊࡑࢀ࡜ࡢ
࡝ࡢࡼ࠺࡞㐃ᦠࡀ࡛ࡁࡿ࠿ࡢ᳨ウࡣᚲせ࡞ࡢ࡛ࡣ࡞࠸ࡔࢁ࠺࠿ࠋ

− 113 −

− 114 −外部点検評価アンケートに同封した資料

資料１

基礎生物学研究所 平成 25 年度実績の概要と将来計画

資料２

2013 年発表論文リスト

資料３

基礎生物学研究所の概要

資料４

過去の外部点検評価会議での指摘事項と対応− 115 −

資料１

基礎生物学研究所 平成 25 年度実績の概要と将来計画（本誌 P.3 に掲載）

− 117 −

− 118 −

資料２






2013ᖺⓎ⾲ㄽᩥࣜࢫࢺ
年発表論文リスト

（2013
年 $QQXDO5HSRUW
Annual Reportࡢཎ✏࠿ࡽ
の原稿から
2013
年に発表された㸦 ᖺ
ᖺ࡟Ⓨ⾲ࡉࢀࡓ
論文リストを抜き出したものを資料２とした。
ㄽᩥࣜࢫࢺࢆᢤࡁฟࡋࡓࡶࡢࢆ㈨ᩱ㸰࡜ࡋࡓࠋ
㸧）












































 ᖺ  ᭶Ⓨ⾜
SGI ࣇ࢓࢖ࣝࡣࠊୗグ 85/ ࡛ࢲ࣮࢘ࣥࣟࢻ࡛ࡁࡲࡍࠋ
KWWSZZZQLEEDFMSSUHVVURRPSGIDQQXDOSGI

− 119 −

− 120 −資料３

基礎生物学研究所の概要（本誌 P.23 に掲載）

− 121 −

− 122 −資料４

過去の外部点検評価会議での指摘事項と対応− 123 −

㐣ཤࡢእ㒊Ⅼ᳨ホ౯఍㆟࡛ࡢᣦ᦬஦㡯࡜ᑐᛂ
㸦L㸧Ꮫ⾡◊✲࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
㸦ᖹ㸰㸰㸧ᣦ᦬㸸ከᵝ࡞⏕≀✀ࢆ㥑౑ࡋ࡚άⓎ࡟◊✲ࢆᒎ㛤ࡋࠊ኱ࡁ࡞ᡂᯝࢆୖࡆ࡚࠸ࡿࠋ
ᡂᯝࡢ࢔ࣆ࣮ࣝ᪉ἲ࡜ࡋ࡚ࠊእ㒊ࡢᣦᶆࢆ฼⏝ࡍࡿࡤ࠿ࡾ࡛࡞ࡃࠊ⛉Ꮫⓗ࡞ព⩏ࢆᐈほⓗ࡟♧ࡍ᪉ἲࢆᕤኵࡋ࡚࡯ࡋ࠸ࠋ≉ᐃࡢศ㔝ࢆᐃࡵࡎࠊᇶ♏⏕≀Ꮫ࡜ࡋ࡚㔜せ࡞◊✲ࢆ⾜ࡗ࡚࠸ࡿⱝᡭ◊✲⪅ࢆ᥇⏝ࡋ࡚ࡁࡓࡇࡇᩘᖺࡢே஦ࡣホ౯࡛ࡁࡿࠋ௒ᚋࠊࡉࡽ࡟ᙼࡽࡢ◊✲ࡀⓎᒎ࡛ࡁࡿࡼ࠺◊✲ᡤ࡜ࡋ࡚ࡢ㓄៖ࡀᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸰㸧ᑐᛂ㸸⮬ᕫホ౯࡟ࡘ࠸࡚ᐈほᛶࢆ☜ಖࡍࡿࡓࡵ࡟ࠊࡼࡾከ㠃ⓗ࡞ゎᯒ࡟ᇶ࡙ࡃ㈨ᩱࢆබ㛤ࡍࡿᚲせࡀ࠶ࡿࠋࡲࡓࠊࡑࡢホ౯ᡭἲ࡟ࡘ࠸࡚㆟ㄽࢆ㛤ጞࡋࡓࠋ㸦ᖹ㸰㸱㸧ᣦ᦬㸸㉁ࡢ㧗࠸◊✲ࡀ⥅⥆ⓗ࡟Ⓨಙࡉࢀ࡚࠸ࡿࡀࠊ௒ᚋࡇࡢάືࢆ⥔ᣢ࣭Ⓨᒎࡉࡏࡿࡓࡵ࡟ࡣࠊ᪥ᮏ඲యࡢᇶ♏⏕≀ᏛࡢỈ‽ࢆ㧗ࡵࡿ኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ࡢ࣑ࢵࢩࣙࣥ
ࢆ⪃៖ࡋ࡞ࡀࡽࡶࠊ⮬ࡽࡢ◊✲άື࡟ࡼࡾὀຊࡍ࡭ࡁࡔࢁ࠺ࠋࡲࡓࠊࡇࡢᩘᖺ㛫࡟╔௵ࡋࡓⱝᡭᩍᤵ࡟ᑐࡋ࡚ࠊ◊✲ᡤࡀேࠊሙᡤࠊ㈨㔠ࡢ㠃࡛ࡢࢧ࣏࣮ࢺ➼ࡢ㓄៖ࢆࡍࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋࡲࡓࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࡛◊✲ᡂᯝࢆୖࡆࡓᩍᤵࠊ෸ᩍᤵࡀ኱Ꮫ➼࡟ᚠ⎔ࡍࡿࡇ࡜ࡀ
ᮃࡲࡋࡃࠊᅜෆ࡟ὶືᛶࡢ㧗࠸ேᮦ஺ὶࢩࢫࢸ࣒ࢆࡘࡃࡿ㆟ㄽࡀᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸱㸧ᑐᛂ㸸኱Ꮫඹྠ฼⏝ᶵ㛵ࡢ࣑ࢵࢩࣙࣥࢆᯝࡓࡋࡘࡘࠕ⮬ࡽࡢ◊✲άືࡢỈ‽ࢆࡉࡽ࡟㧗ࡵࡿࠖࡇ࡜࡟ࡘ࠸࡚ࡣࠊ◊✲ᡤ㐠Ⴀࡢຠ⋡໬ࠊඹྠ฼⏝◊✲ࡢࡓࡵࡢ㐺ษ࡛ᶵືⓗ࡞ேᮦ㓄⨨࡟ࡼࡗ࡚◊✲⪅ࡢ◊✲᫬㛫ࢆ☜ಖࡍࡿດຊࢆ⾜࠺ࠋࡲࡓࠊ
ࠕ◊✲⪅ࡢ஺ὶࠖࢆಁ㐍ࡋ◊✲ࢆάᛶ໬ࡍࡿࡓࡵ࡟ࠊ኱Ꮫࢆᮏົ࡜ࡍࡿᐈဨ◊✲㒊㛛ᩍᤵ  ྡࡢ㑅⪃ࢆ㛤ጞࡋࡓࠋࡲࡓࠊ
ᅜෆ኱Ꮫ➼࡜ࡢேᮦ஺ὶࢆ㐍ࡵࡿࡓࡵࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ࡜ࡋ࡚ࢧࣂࢸ࢕࢝ࣝไᗘࢆ᳨ウࡋ࡚࠸ࡿࠋ㸦ᖹ㸰㸲㸧ᣦ᦬㸸኱Ꮫඹྠ฼⏝ᶵ㛵࡜ࡋ࡚ࡢᙺ๭ࢆᯝࡓࡋ࡞ࡀࡽࠊ⮬ࡽࡢ◊✲άື࡟ࡼࡾὀ
ຊࡋࠊᅜ㝿ⓗ࡞◊✲ᶵ㛵࡟ẚ⫪ࡍࡿ◊✲ᣐⅬ࡜ࡋ࡚◊✲ࡢ㉁ࢆࡉࡽ࡟㧗ࡵࡿࡇ࡜ࢆᮇᚅࡍࡿࠋ
ࢸࢽࣗ࢔ࢺࣛࢵࢡไᗘࡢᑟධ࡞࡝ࡶྵࡵ࡚ࠊ◊✲ᡤࡀ✚ᴟⓗ࡟ⱝᡭ◊✲⪅ࠊዪᛶ◊✲⪅ࢆ⫱ᡂࡍࡿດຊࢆ⥅⥆ࡍࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋࡲࡓࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࡛◊✲ᡂᯝࢆୖࡆࡓ෸ᩍ
ᤵࡸຓᩍࡀ኱Ꮫ➼࡟㌿ฟ࡛ࡁࡿࡼ࠺ே஦ࡢὶືᛶࢆ㧗ࡵࡿࡇ࡜ࡶᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸲㸧ᑐᛂ㸸◊✲ࡢ㉁ࡢホ౯࡟ࡘ࠸࡚ࡣࠊእ㒊ጤクࡢㄪᰝ࡟ᘬ⏝ᗘᣦᩘ࡟ከ㠃ⓗゎᯒࢆຍ࠼ࡿࠊᅜ㝿ẚ㍑ᑐ㇟ࢆቑࡸࡍ࡞࡝ࡢ᳨ウࢆ⾜࠺ࠋⱝᡭ◊✲⪅ࡢ⫱ᡂࡢࡓࡵࠊᘬࡁ⥆ࡁ NIBBࣜࢧ࣮ࢳࣇ࢙࣮ࣟไᗘࢆ⥅⥆࣭Ⓨᒎࡉࡏࡿ࡜࡜ࡶ࡟ࠊ⏨ዪඹྠཧ⏬᥎㐍ࡢࡓࡵ࡟ࠊ⌧ᅾࠊዪᛶ⊂❧෸ᩍᤵࡢබເࢆ⾜ࡗ࡚࠸ࡿࠋ

− 124 −

㸦LL㸧ඹྠ฼⏝࣭ඹྠ◊✲࡟㛵ࡍࡿάື࡟ࡘ࠸࡚ 㸦ᖹ㸰㸰㸧ᣦ᦬㸸」ᩘࡢᨭ᥼᪋タࢆ஧ࡘࡢࢭࣥࢱ࣮࡟⤫ྜࡋࠊ࣓ࢲ࢝➼ࡢࣂ࢖࢜ࣜࢯ࣮ࢫ
ࡸḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮➼ࡢ᭱ඛ➃ᶵჾࡢඹྠ฼⏝యไࢆᩚഛࡋࠊ◊✲⪅ࢥ࣑ࣗࢽࢸ࢕࣮ࡢせᮃ࡟ᰂ㌾࡟ᑐᛂ࡛ࡁࡿయไࢆసࡗࡓࡇ࡜࡟ࡼࡗ࡚ࠊᐇ㝿࡟ከࡃࡢ฼⏝⪅ࢆཷࡅධࢀ࡚࠸ࡿࡇ࡜ࡣホ౯࡛ࡁࡿࠋᇶ⏕◊࠿ࡽ㌿ฟࡋࡓ◊✲⪅࡞࡝ࡀࠊᇶ⏕◊࡛ࡢඹྠ◊✲ࢆ⥆ࡅࡿࡓࡵ࡟ඹྠ฼⏝ࡢ௙⤌ࡳࢆ㛗ࡃ฼⏝ࡍࡿࡢࡣṆࡵࡿ࡭ࡁ࡛࠶ࡿࠋ
㸦ᖹ㸰㸰㸧ᑐᛂ㸸㌿ฟࡋࡓ◊✲⪅࡟ࡼࡿඹྠ◊✲࡟ࡘ࠸࡚ࡣࠊྠ୍◊✲ࡢ⥅⥆࡟ࡘ࠸࡚ࠊࡑࡢᚲせᛶࢆၥ࠺࡞࡝ࠊࡼࡾཝᐦ࡞ᑂᰝࢆ⾜࠺ࠋ㸦ᖹ㸰㸱㸧ᣦ᦬㸸࣓ࢲ࢝➼ࡢࣂ࢖࢜ࣜࢯ࣮ࢫࡸḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮ࠊගࢩ࣮ࢺᆺ㢧ᚤ㙾
㸦DSLM㸧
ࠊ㉥እ⥺࣮ࣞࢨ࣮ㄏ㉳㑇ఏᏊⓎ⌧᧯సἲ㸦IR-LEGO㸧࡞࡝ࡢ᭱ඛ➃ᶵჾࡢඹྠ฼⏝ࡣ㧗ࡃホ౯ࡉࢀࢥ࣑ࣗࢽࢸ࢕࣮ࡢ◊✲᥎㐍࡟㈉⊩ࡋ࡚࠸ࡿࠋ୍᪉ࠊࡇࡢࡼ࠺࡞ඹྠ฼⏝◊✲ࡢ඘ᐇࠊᣑ኱ࡣ◊✲⪅࡟࡜ࡗ࡚ࡶ኱ࡁ࡞㈇ᢸࢆక࠺ࡓࡵࠊࣜࢯ࣮ࢫࠊඛ➃ᶵჾࢆ⥔ᣢ࣭⟶⌮ࡍࡿ◊✲⪅ࡢᨭ᥼ࠊᐃᮇⓗ࡞ᶵჾ᭦᪂➼ࢆ◊✲ᡤࡀィ⏬ⓗ࡟⾜ࡗ࡚࠸ࡃࡇ࡜ࡀᚲせࡔࢁ࠺ࠋࡲࡓࠊྠᵝ࡟ඹྠ฼⏝ࡸᅜ㝿ࢩ࣏ࣥࢪ࣒࢘㛤ദ➼ࢆ⾜ࡗ࡚࠸ࡿ⌮໬Ꮫ◊✲ᡤ㸦Ⓨ⏕࣭෌⏕⛉Ꮫ⥲ྜ◊✲ࢭࣥࢱ࣮㸧࡜ࡢᕪู໬ࡸ༠ຊࡶᚲせ࡛ࡣ࡞࠸࠿ࠋ
㸦ᖹ㸰㸱㸧ᑐᛂ㸸ࠕ⌮໬Ꮫ◊✲ᡤ࡜ࡢ◊✲ࡢᕪู໬ࠊ㐃ᦠࠖ࡟ࡘ࠸࡚ࡣࠊ௒ᚋࡢ᪥ᮏࡢᏛ⾡ືྥࢆぢ࡞ࡀࡽࠊᚲせ࡛࠶ࢀࡤ㐃ᦠయไࢆᵓ⠏ࡍࡿ࡞࡝ࡢ㆟ㄽࢆ㐍ࡵ࡚࠸ࡁࡓ࠸ࠋ

㸦ᖹ㸰㸲㸧ᣦ᦬㸸኱Ꮫ㐃ᦠࣂ࢖࢜ࣂࢵࢡ࢔ࢵࣉࣉࣟࢪ࢙ࢡࢺ㸦IBBP㸧ࠊḟୡ௦ DNA ࢩ࣮ࢣࣥࢧ࣮ࠊගࢩ࣮ࢺᆺ㢧ᚤ㙾㸦DSLM㸧ࠊ㉥እ⥺࣮ࣞࢨ࣮ㄏ㉳㑇ఏᏊⓎ⌧᧯సἲ㸦IR-LEGO㸧࡞࡝ࡢ᭱ඛ➃ᶵჾࠊ࠾ࡼࡧ᪂つࣔࢹࣝ⏕≀㛤Ⓨࡢඹྠ฼⏝ࡣࢥ࣑ࣗࢽࢸ࢕࣮ࡢ◊✲᥎㐍࡟኱ࡁ࡞㈉⊩ࢆࡋ࡚࠸ࡿࠋ௒ᚋࡉࡽ࡟኱Ꮫ➼ࡢ◊✲⪅࡟ඹྠ฼⏝◊✲ࡢࡋࡃࡳࢆ࿘▱ࡋࠊ⏦ㄳ࠿ࡽ฼⏝ࡲ࡛ࡢ⎔ቃࢆᩚ࠼ࡿࡇ࡜࡟ࡼࡗ࡚฼౽ᛶࢆ㧗ࡵࡿࡇ࡜ࡀᚲせࡔࢁ࠺ࠋ◊✲ᡂᯝࡢ✚ᴟⓗ࡞Ⓨಙࡶ㔜せ࡛࠶ࡿࠋࡲࡓࠊ㐺ษ࡞ேဨ⿵ᙉࡸタഛ᭦᪂ࡢࡓࡵࡢண⟬☜ಖࡢດຊ࡟ࡼࡾࠊඹྠ
฼⏝◊✲ࡢࡉࡽ࡞ࡿ㧗ᗘ໬ࠊᣑ኱ࢆᮃࡴࠋࡲࡓࠊඹྠ฼⏝ࡸᅜ㝿ࢩ࣏ࣥࢪ࣒࢘㛤ദ➼ࢆ⾜ࡗ࡚࠸ࡿ⌮໬Ꮫ◊✲ᡤ㸦⎔ቃ㈨※⛉Ꮫ◊✲ࢭࣥࢱ࣮࡞࡝㸧࡜ࡢᕪู໬ࡸ㐃ᦠࡶᚲせ࡛ࡣ࡞࠸࠿ࠋ
㸦ᖹ㸰㸲㸧ᑐᛂ㸸ඹྠ฼⏝◊✲ࡢ୰࡟ࡣཷධᩍဨ࡜஦๓ᡴࡕྜࢃࡏࡀᚲせ࡛࠶ࡾࠊᛂເࡢᩜ
ᒃࡀ㧗࠸࡜ឤࡌࡿࡶࡢࡀ࠶ࡿ࡜ࡢᣦ᦬ࡀ࠶ࡗࡓࡇ࡜࠿ࡽࠊඹྠ฼⏝◊✲ࢆࢥ࣮ࢹ࢕ࢿ࣮ࢺࡍ
ࡿࡓࡵࠊ஦๓┦ㄯ࡟ᛂࡌࡿ࡞࡝ࡢᥐ⨨ࢆㅮࡎࡿࠋࡲࡓࠊඹྠ฼⏝◊✲࡟ࡘ࠸࡚Ꮫ఍࡞࡝ࢆ㏻
ࡌࡓ࿘▱࡟ດࡵࡿࠋ


− 125 −

㸦LLL㸧ᅜ㝿㐃ᦠཬࡧᗈሗ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
㸦ᖹ㸰㸰㸧ᣦ᦬㸸EMBL ➼࡜ࡢᅜ㝿ඹྠ◊✲ࡸඹྠࢩ࣏ࣥࢪ࣒࢘㛤ദࡀάⓎ࡟ᐇ᪋ࡉࢀ࡚࠸
ࡿࠋಶேࡸ⤌⧊࡛ࣞ࣋ࣝࡢ㐃ᦠ࠿ࡽ῝໬ࡉࡏࠊࡑࢀࡒࢀࡢ◊✲ᶵ㛵ࡢ≉Ⰽࢆ⏕࠿ࡋࡓලయⓗ࡞཮᪉ྥࡢඹྠ◊✲࡞࡝ࡉࡽ࡟ព⩏῝࠸㐃ᦠ࡬⤖ࡧࡘࡅࡿࡇ࡜ࡀᚲせ࡛࠶ࡿࠋᇶ⏕◊ࢆᅜ㝿໬ࡍࡿࡓࡵ࡟ࠊᇶ⏕◊ࡀᾏእ◊✲ᶵ㛵࡟ᡤᒓࡍࡿ᪥ᮏே◊✲⪅ࡢཷࡅ─࡟࡞ࡗ࡚ࡶࡼ࠸ࡢ࡛
ࡣ࡞࠸࠿ࠋᗈሗ࡟㛵ࡋ࡚ࡣࠊ࣮࣒࣮࣍࣌ࢪࢆⱥㄒ⾲グ࡟ࡍࡿࡇ࡜࡟ຊⅬࢆ⨨࠸࡚㨩ຊⓗ࡞ࡶࡢ࡟ࡋ࡚࠸ࡃࡇ࡜ࡀࠊඃ⚽࡞␃Ꮫ⏕ࢆ☜ಖࡍࡿࡓࡵ࡟ࡶ㔜せ࡛࠶ࡿࠋ
㸦ᖹ㸰㸰㸧ᑐᛂ㸸ᅜ㝿໬࡟ࡘ࠸࡚ࡣࠊᾏእ◊✲ᶵ㛵࡟ᅾ⡠ࡍࡿ᪥ᮏே◊✲⪅ࡢࢹ࣮ࢱ࣮࣋ࢫ
ࡸ◊✲⪅ࢿࢵࢺ࣮࣡ࢡࡢᵓ⠏࡟ࡘ࠸࡚㆟ㄽࢆ㛤ጞࡋࡓࠋ㸦ᖹ㸰㸱㸧ᣦ᦬㸸◊✲ᡂᯝࡢࣉࣞࢫ࣮ࣜࣜࢫ࡟ࡘ࠸࡚ࡣࠊᇶ♏◊✲ࡣ࣓ࢹ࢕࢔࡟ྲྀࡾୖࡆࡽ
ࢀ࡟ࡃ࠸㠃ࡀ࠶ࡿࡢ࡛ࠊ◊✲άືࢆ♫఍࡟࿘▱ࡍࡿࡓࡵ࡟ᖹ᫆࡞ゎㄝࢆᚰࡀࡅࡿ࡜ඹ࡟ࠊⱥ
ㄒ࡛ࡢゎㄝࠊ࢖ࣛࢫࢺࡢᤄධ࡞࡝ࠊᐃᮇⓗ࡟ࣉࣞࢫ࣮ࣜࣜࢫࢆ㜀ぴࡍࡿࣇ࢛࣮ࣟ࣡ࢆ⋓ᚓࡍࡿࡓࡵࡢ୍ᒙࡢດຊ࡜ᕤኵࡀᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸱㸧ᑐᛂ㸸◊✲ᡤࡢࠕ◊✲άືࢆ♫఍࡟࿘▱ࡍࡿࠖࡓࡵࡢດຊ࡟ࡘ࠸࡚ࡣࠊࣉࣞࢫࣜ
࣮ࣜࢫゎㄝࡢᖹ᫆ࡉࢆᚰࡀࡅࡿ࡜࡜ࡶ࡟ࠊグ⪅᠓ㄯ఍ࢆタࡅࡿ࡞࡝ࡢດຊࢆ⾜࠺ࠋ㸦ᖹ㸰㸲㸧ᣦ᦬㸸ᅜ㝿㐃ᦠ࡟ࡘ࠸࡚ࡣࠊḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸦EMBL㸧࡞࡝࡜ࡢ஺ὶᐇ⦼
ࡀ༑ศ࠶ࡾࠊࡲࡓ⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦OBC㸧࡞࡝ࣘࢽ࣮ࢡ࡞ྲྀࡾ⤌ࡳࡀホ౯ࡉࢀࡿࡀࠊᙧ㧁໬ࡏࡠࡼ࠺ලయⓗ࡞┠ᶆࢆᣢࡗ࡚㐍ࡵ࡚࠸ࡓࡔࡁࡓ࠸ࠋ◊✲ᡤࡢ࣮࣒࣮࣍࣌ࢪ
ࡣⱥㄒ໬ࠊື⏬ࡢࣜࣥࢡ࡞࡝ࡀ඘ᐇࡋ࡚࠾ࡾࠊᖖ࡟᪂ࡋ࠸᝟ሗࡀⓎಙࡉࢀ࡚࠸ࡿࠋ
㸦ᖹ㸰㸲㸧ᑐᛂ㸸ᩍဨࡢᅜ㝿໬ࢆ㐍ࡵࡿࡓࡵ࡟ࢧࣂࢸ࢕࢝ࣝไᗘࡢ᳨ウࢆ㐍ࡵ࡚࠸ࡿࠋ

㸦LY㸧᪂㡿ᇦࡢ㛤ᣅ࣭ᑗ᮶ィ⏬࡟ࡘ࠸࡚
㸦ᖹ㸰㸰㸧ᣦ᦬㸸⏕≀Ꮫᅜ㝿㧗➼ࢥࣥࣇ࢓ࣞࣥࢫ㸦OBC㸧ࡣ㐺ษ࡟㛤ദࡉࢀ࡚࠸ࡿࡀࠊ௒ᚋ
ࢸ࣮࣐ࡢ㑅ᐃἲ࡞࡝୍ᒙࡢᕤኵࡀᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸱㸧ᣦ᦬㸸ࡇࢀ࠿ࡽࡢᇶ♏⏕≀Ꮫ࡟ࡣࣂ࢖࢜࢖࣓࣮ࢪࣥࢢࡸᩘ⌮ࣔࢹࣝࡢᵓ⠏ࠊࢩ࣑࣮ࣗࣞࢩࣙࣥࡀᚲせ࡛࠶ࡾࠊ㐺ษ࡞ேᮦ☜ಖ࡟ࡼࡾࡑࢀࡽ㡿ᇦࢆᙉ໬ࡍࡿᚲせࡀ࠶ࡿࠋྠᵝ
ࡢ◊✲ࢆ⾜ࡗ࡚࠸ࡿ⌮໬Ꮫ◊✲ᡤ㸦⏕࿨ࢩࢫࢸ࣒◊✲ࢭࣥࢱ࣮㸸QBiC㸧࡜ࡶ㐃ᦠࡋ࡚ྠ㡿ᇦࢆ᥎㐍ࡋ࡚ḧࡋ࠸ࠋ࣮࣮࢟࣡ࢻ࡜ࡋ࡚ࠕ⎔ቃࠖࡣ㐺ษ࡛࠶ࡿࡀࠊࡑࡢ㔜せᛶࢆ♫఍࡟ッồࡍࡿࡓࡵ࡟ࡣࠕ⏕࿨⌧㇟ࡢ㠃ⓑࡉࠖࢆఏ࠼ࡿᚲせࡀ࠶ࡿࠋ᪂ࡋ࠸ࣔࢹࣝ⏕≀ࡢ㛤ᣅ࡟ຍ࠼࡚ࠊ
᪤Ꮡࡢࣔࢹࣝ⏕≀ࢆ῝ࡃ᥀ࡾୗࡆࡿ᪉ྥᛶࡶᚲせࡔࢁ࠺ࠋࡲࡓࠊࡇࢀ࠿ࡽࡢᑗ᮶ィ⏬࡟ࡣࠊ− 126 −

ᅜ㝿ࢩ࣏ࣥࢪ࣒࢘࠿ࡽ୍Ṍࡉࡽ࡟㋃ࡳ㎸ࢇࡔࠊேᮦ஺ὶࢆど㔝࡟ධࢀࡓᅜ㝿໬ࡀᚲせ࡛࠶ࡿࠋ
㸦ᖹ㸰㸱㸧ᑐᛂ㸸ࠕᅜ㝿໬ࠖ࡟㛵ࡋ࡚ࡣ RA ไᗘࡢᰂ㌾࡞㐠⏝࡟ࡼࡗ࡚እᅜே␃Ꮫ⏕࡟ᡭཌ࠸⤒῭ⓗᨭ᥼ࢆ⾜࠺࡞࡝ࠊཷධయไࡢᨵၿ࡟ࡼࡿᅜ㝿໬ࢆᘬࡁ⥆ࡁ⾜࠺ࠋࡲࡓࠊ㐃ᦠ┦ᡭඛ࡜ࡢ㛫࡟⮬Ⓨⓗ࡞ᅜ㝿ඹྠ◊✲ࡸேᮦ஺ὶࢆ⏕ࡴࡓࡵࡢ⎔ቃ࡙ࡃࡾ࡟ࡘ࠸࡚ࡢ㆟ㄽࢆ㛤ጞࡍࡿࠋ 㸦ᖹ㸰㸲㸧ᣦ᦬㸸ࠕኚື⎔ቃୗ࡛ࡢ⏕≀Ꮫࠖࢆ୰ᚰࢸ࣮࣐࡟ᤣ࠼ࡓ኱ᆺ◊✲ィ⏬࡛ᇶ♏⏕≀Ꮫ◊✲ᡤࡀ࣮ࣜࢲ࣮ࢩࢵࣉࢆྲྀࡿࡇ࡜ࢆᮇᚅࡋ࡚࠸ࡿࠋࡲࡓࠊศᏊࠊ⣽⬊ࣞ࣋ࣝ࠿ࡽಶయࣞ࣋
ࣝࡢ◊✲ࢆࡉࡽ࡟⩌㞟࡛ࣞ࣋ࣝᤊ࠼ࡿ⏕ែᏛࡢどⅬࡶຍ࠼࡚ḧࡋ࠸ࠋྠ◊✲࡟࠾࠸࡚ࡣ኱つᶍ࡞ࢹ࣮ࢱࡀ཰㞟ࡉࢀࡿࡀࠊࡑࡢࢹ࣮ࢱゎᯒࡢࡓࡵࡢタഛࠊேဨࡢ☜ಖࡀᚲせࡔࢁ࠺ࠋ᪂つࣔࢹࣝ⏕≀㛤Ⓨ࡟ࡘ࠸࡚ࡣࠕከᵝ࡞⏕≀ᶵ⬟ࠖࡢࠕከᒙⓗゎᯒࠖࢆྍ⬟࡟ࡍࡿࡇ࡜ࡣ㔜せ࡛࠶ࡾࠊ௒ᗘࡑࡢࡼ࠺࡞㝵ᒙࢆ㉸࠼ࡿศ㔝ࡢ◊✲⪅⫱ᡂ࡟ࡶດࡵ࡚ḧࡋ࠸ࠋ㸦ᖹ㸰㸲㸧ᑐᛂ㸸ࠕኚື⎔ቃୗ࡛ࡢ⏕≀Ꮫࠖ◊✲ࢆ᥎㐍ࡍࡿࡓࡵ࡟ࠊᖹᡂ  ᖺᗘࡢ⿵ṇண⟬࡛ࠊศᯒᶵჾࠊື᳜≀⫱ᡂ᪋タࠊ㑇ఏᏊཬࡧ⏬ീ᝟ሗࡢࢫࢺ࣮ࣞࢪタഛ➼ࡢ඘ᐇࢆᅗࡗ࡚࠸
ࡿࠋྠ᫬࡟ࠊ኱つᶍࢹ࣮ࢱࡢゎᯒ࡟㛵ࡍࡿࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫࠊᩍ⫱ࣉࣟࢢ࣒ࣛࢆᙉ໬ࡍࡿࠋ
௒ᚋࠊࢹ࣮ࢱࡢᩘ⌮ゎᯒ࡞࡝ྲྀᚓࡋࡓࢹ࣮ࢱࡢά⏝ࡢࡓࡵ࡟ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓ᪂ศ㔝๰ᡂࢭࣥࢱ࣮㸦࢖࣓࣮ࢪࣥࢢࢧ࢖࢚ࣥࢫศ㔝㸧࡜ࡢ㐃ᦠࡸேⓗ⿵ᙉࡶ⪃៖ࡋࡓ࠸ࠋ

㸦Y㸧ⱝᡭ◊✲⪅ࡢ⫱ᡂ࡟㛵ࡍࡿάື࡟ࡘ࠸࡚
㸦ᖹ㸰㸰㸧ᣦ᦬㸸␃Ꮫ⏕ࡢཷࡅධࢀ࡟ࡘ࠸࡚ࡣࠊዡᏛ㔠ࡢ඘ᐇࠊㅮ⩏ࡢⱥㄒ໬࡞࡝ࡢㄢ㢟࡬ࡢᑐ⟇ࢆ㐍ࡵࡿ࡭ࡁ࡛࠶ࡿࠋ ᖺ୍㈏ไ኱Ꮫ㝔ࡢ 㸪 ᖺ࠿ࡽࣜࢧ࣮ࢳ࢔ࢩࢫࢱࣥࢺไᗘ࡟ࡼࡿ⤒῭ⓗ⿵ຓࡀ࠶ࡿⅬࡣࡶࡗ࡜ᗈሗࡍ࡭ࡁ࡛࠶ࡿࠋ
㸦ᖹ㸰㸰㸧ᑐᛂ㸸኱Ꮫ㝔ࡢᅜ㝿໬ࢆ㐍ࡵࡿࡓࡵࠊᅜ㈝␃Ꮫ⏕ไᗘࡢ᥎⸀࡟㛫࡟ྜ࠺ࡼ࠺እᅜ
ேཷ㦂⪅ࡢ㑅ᢤ᫬ᮇࡸ᪉ἲࢆᨵၿࡋࡓ࡯࠿ࠊ⚾㈝␃Ꮫ⏕࡟ࡶࣜࢧ࣮ࢳ࢔ࢩࢫࢱࣥࢺไᗘࢆ㐺⏝ࡍࡿࡇ࡜࡜ࡋࡓࠋ

㸦ᖹ㸰㸱㸧ᣦ᦬㸸◊✲άືࢆάᛶ໬ࡍࡿࡓࡵ࡟ࡣ኱Ꮫ㝔⏕☜ಖࡶ㔜せ࡛࠶ࡾࠊ≉࡟╔௵┤ᚋࡢᩍᤵࡢ◊✲ᐊ࡛ࡣࠊ࠸࠿࡟኱Ꮫ㝔⏕ࢆ☜ಖ࡛ࡁࡿ࠿ࡀ⏕࿨⥺࡜࡞ࡿࠋᏛ⏕ເ㞟࡟㝿ࡋ࡚ RA⤒㈝࡟ࡼࡿ⤒῭ⓗᨭ᥼࡞࡝࡟ຍ࠼ࠊᑡேᩘไᩍ⫱࡞࡝◊✲ᡤࡢ≉ᚩࢆᙉㄪࡋࡓເ㞟ෆᐜ࡟ࡋ࡚ࡣ࡝࠺࠿ࠋࡲࡓࠊᏛ఩ྲྀᚓᚋ࡟⊂❧ࡋࡓ◊✲⪅࡟࡞ࡿࡓࡵࡢ᪂ࡋ࠸࣏ࢪࢩࣙࣥࡢ๰タࡸࠊᏛ఩ྲྀᚓᚋࡢⱝᡭ◊✲⪅ࡀ◊✲㈨㔠ࡸタഛࢆᚰ㓄ࡏࡎ࡟୍ᐃᮇ㛫◊✲ࢆ⥆ࡅࡽࢀࡿ⎔ቃᩚഛ࡞࡝ࡶᮃࡲࢀࡿࠋ
㸦ᖹ㸰㸱㸧ᑐᛂ㸸ࠕ኱Ꮫ㝔⏕☜ಖࠖ࡟ࡘ࠸࡚ࡣࠊ኱Ꮫ⏕ᑐ㇟ࡢᐇ⩦ࢆ⾜࠸▱ྡᗘྥୖ࡟ດࡵࡿ

− 127 −

࡞࡝Ꮫ⏕ເ㞟ࡢᕤኵࢆᘬࡁ⥆ࡁ⾜࠺ࠋࡲࡓࠊNIBB ࣜࢧ࣮ࢳࣇ࢙࣮ࣟ㸦࣏ࢫࢻࢡ㸧ไᗘ࡛㞠⏝ࡍࡿⱝᡭ◊✲⪅ࡀඃࢀࡓ◊✲ᡂᯝࢆୖࡆࡓሙྜࠊ௵ᮇ⤊஢ᚋ࡟⊂❧ࡋࡓ◊✲ᐊࢆᣢ࡚ࡿไ
ᗘࡢᑟධ࡟ࡘ࠸᳨࡚ウࡍࡿࠋ㸦ᖹ㸰㸲㸧ᣦ᦬㸸኱Ꮫ㝔⏕☜ಖࡢࡓࡵࡢయ㦂ධᏛࡢᐇ᪋ࡣປຊࢆక࠺ࡶࡢࡢࠊ኱Ꮫ㝔ཷ㦂⏕ࡢከࡃࡀయ㦂ධᏛ⤒㦂⪅࡛࠶ࡿࡇ࡜ࢆ⪃࠼ࡿ࡜኱ኚຠᯝⓗ࡛࠶ࡿ࡜ホ౯࡛ࡁࡿࠋࡉࡽ࡟ࠊ኱
Ꮫ㝔⏕ࡢᅜ㝿ᛶࢆ㧗ࡵࡿࡓࡵ࡟ᾏእࡢ◊✲ᐊ࡟▷ᮇ㛫㏦ࡿ࡞࡝ࡢヨࡳࢆ⾜࠺ࡇ࡜ࢆ⪃࠼࡚ࡶⰋ࠸ࡔࢁ࠺ࠋࢫ࣮ࣃ࣮ࢧ࢖࢚ࣥࢫࣁ࢖ࢫࢡ࣮ࣝ㸦SSH㸧࡬ࡢ༠ຊ࡞࡝✚ᴟⓗ࡟⾜ࡗ࡚࠾ࡾホ౯ࡉࢀࡿࡀࠊᇶ⏕◊ࡢ≉ᚩ࠶ࡿ᪋タࢆ฼⏝ࡋ࡚ࠊ඲ᅜࡢ㧗ᰯ࣭୰Ꮫࢆᑐ㇟࡜ࡍࡿࡇ࡜ࡶ⪃࠼࡚ࡣ࡝࠺࠿ࠋ
㸦ᖹ㸰㸲㸧ᑐᛂ㸸኱Ꮫ㝔⏕☜ಖࡢࡓࡵࠊᘬࡁ⥆ࡁయ㦂ධᏛཬࡧࢧ࣐࣮ࢫࢡ࣮ࣝࢆ⥅⥆ࡍࡿ࡜࡜ࡶ࡟ࠊ࡜ࡃ࡟ᾏእ࠿ࡽࡢ␃Ꮫ⏕࡟ᑐࡋ࡚ࡣࠊཷ㦂᪉ἲࡢᨵၿࢆᅗࡿ࡯࠿ࠊ᪂ࡓ࡟タ⨨ࡍࡿࠕࢪࣗࢽ࢔ࣜࢧ࣮ࢳࣇ࢙࣮ࣟࠖไᗘ࡛኱Ꮫ㝔⏕άࢆᨭ᥼ࡍࡿࠋ඲ᅜࡢ㧗ᰯ࣭୰Ꮫ࡬ࡢ࢔࢘ࢺ
࣮ࣜࢳάືࡢᣑ኱࡟ࡘ࠸࡚ࡣࠊྛᏛ఍ࡢྠᵝ࡞άື࡜㐃ᦠࡋ࡚⤌⧊ⓗ࡟ྲྀࡾ⤌ࡳࡓ࠸ࠋ

− 128 −

５．発表論文資料
１）２０１３−２０１１ 発表論文リスト
２）２０１３−２０１１ プレスリリースと新聞報道− 129 −

            㸯㸧㸰㸮㸯㸱㸫㸰㸮㸯㸯Ⓨ⾲ㄽᩥࣜࢫࢺ
㧗ḟ⣽⬊ᶵᵓ㸦すᮧ◊㸧2013 ᖺ
Cui, S., Fukao, Y., Mano, S., Yamada, K., Hayashi, H., and Nishimura, M. (2013). Proteomic analysis
reveals that the Rab GTPase RabE1C is involved in the degradation of the peroxisomal protein receptor
PEX7 (peroxin 7). J. Biol. Chem. 288, 6014-6023.
Kanai, M., Hayashi, M., Kondo, M., and Nishimura, M. (2013). The plastidic DEAD-box RNA
helicase22, HS3, is essential for plastid function both in seed development and in seedling growth. Plant
Cell Physiol. 54, 1431-1440.
Kobayashi, K., Narise, T., Sonoike, K., Hashimoto, H., Sato, N., Kondo, M., Nishimura, M., Sato, M.,
Toyooka, K., Sugimoto, K., Wada, H., Masuda, T., and Ohta, H. (2013). Role of galactolipid biosynthesisin coordinated㻌 development of photosynthetic complexes and thylakoid membranes during chloroplastbiogenesis in Arabidopsis.㻌 Plant J. 73, 250-261.
Kunieda, T., Shimada, T., Kondo, M., Nishimura, M., Nishitani, K., and Hara-Nishimura, I. (2013).
Spatiotemporal secretion of PEROXIDASE36 is required for seed coat mucilage extrusion in Arabidopsis.
Plant Cell 25, 1355-1367.
Li, L., Shimada, T., Takahashi, H., Koumoto, Y., Shirakawa, M., Takagi, J, Zhao, X., Tu, B., Jin, H., Han,
B., Jia, M., Kondo, M., Nishimura, M., and Hara-Nishimura, I. (2013). MAG2 and three
MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport
in Arabidopsis thaliana. Plant J. 76, 781-791.
Shibata, M., Oikawa, K., Yoshimoto, K., Kondo, M., Mano, S., Yamada, K., Hayashi, M., Sakamoto, W.,
Ohsumi, Y., and Nishimura, M. (2013). Highly oxidized peroxisomes are selectively degraded via
autophagy in Arabidopsis. Plant Cell 25, 4967-4983. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Takagi, J., Renna, L, Takahashi, H., Koumoto, Y., Tamura, K., Stefano, G., Fukao, Y., Kondo, M.,
Nishimura, M., Shimada, T., Brandizzi, F., and Hara-Nishimura, I. (2013). MAIGO5 functions in protein
export from Golgi-associated endoplasmic reticulum exit sites in Arabidopsis. Plant Cell 25, 4658-4675.
Tameshige, T., Fujita, H., Watanabe, K., Toyokura, K. Kondo, M., Tatematsu, K., Matsumoto, N.,
Tsugeki, R., Kawaguchi, M., Nishimura, M., and Okada, K. (2013). Pattern dynamics is adaxial-abaxial
specific gene expression are modulated by a plastid retrograde signal during Arabidopsis thaliana leaf
development. PLoS Genetics 9, e1003655. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Tamura, K., Iwabuchi, K., Fukao, Y., Kondo, M., Okamoto, K., Ueda, H., Nishimura, M., andHara-Nishimura, I. (2013). MyosinXI-i links the nuclear membrane to the cytoskeleton to control nuclear
movement and shape in Arabidopsis. Curr. Biol. 23, 1776-1781.
Yamada, K., Nagano, A.J., Nishina, M., Hara-Nishimura, I., and Nishimura, M. (2013). Identification of
two novel endoplasmic reticulum body-specific integral membrane proteins. Plant Physiol. 161, 108-120.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Mano, S., Nakamura, T., Kondo, M., Miwa, T., Nishikawa, S., Mimura, T., Nagatani, A., and Nishimura,
M. The Plant Organelles Database 3 (PODB3) update 2014: integrating electron micrographs and new
options for plant organelle research. Plant Cell Physiol. 2013 Sep. 18.
2012 ᖺ
Hayashi, M., Nanba, C., Saito M., Kondo, M., Takeda, A., Watanabe, Y., and Nishimura, M. (2012).
Loss of XRN4 function can trigger cosuppression in a sequence-dependent manner. Plant Cell Physiol.
53, 1310-1321.
Nakano, R.T., Matsushima, R., Nagano, A.J., Fukao, Y., Fujiwara, M., Kondo, M., Nishimura, M., andHara-Nishimura, I. (2012). ERMO3/MVP1/GOLD36 is involved in a cell type-specific mechanism for
maintaining ER morphology in Arabidopsis thaliana. PLoS ONE 7, e49103.
Nakayama, M., Kaneko, Y., Miyazawa, Y., Fujii, N., Higashitani, N., Wada, S., Ishida, H., Yoshimoto,− 131 −

K., Yamada, K., Nishimura, M., and Takahashi, H. (2012). A possible involvement of autophagy in
amyloplast degradation in columella cells during hydrotropic response of Arabidopsis roots. Planta 236,
999-1012.
Negishi, T., Oshima, K., Hattori, M., Kanai, M., Mano, S., Nishimura, M., and Yoshida, K. (2012).
Tonoplast- and plasma membrane-localized aquaporin-family transporters in blue hydrangea sepals ofaluminum hyperaccumulating plant. PLoS ONE 7, e43189.
Toyokura, K., Hayashi, M., Nishimura, M., and Okada, K. (2012). Adaxial-abaxial patterning: A novel
function of the GABA shunt. Plant Signal. Behav. 7, 705-707.
2011 ᖺ
Goto, S., Mano, S., Nakamori C., and Nishimura, M. (2011). Arabidopsis ABERRANT PEROXISOME
MORPHOLOGY 9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes. Plant Cell 23,
1573-1587. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Hino, T., Tanaka, Y., Kawamukai, M., Nishimura, K., Mano, S., and Nakagawa, T. (2011). Two Sec13p
homologs, AtSec13A and AtSec13B, redundantly contribute to formation of COPII transport vesicles in
Arabidopsis thaliana. Biosci. Biotechnol. Biochem. 75, 1848-1852.
Mano, S., Miwa, T., Nishikawa, S., Mimura, T., and Nishimura, M. (2011). The Plant Organelles
Database 2 (PODB2): An updated resource containing movie data of plant organelle dynamics. Plant Cell
Physiol. 52, 244-253.
Mano, S., Nakamori, C., Fukao, Y., Araki, M., Matsuda, A., Konod, M., and Nishimura, M. (2011). A
defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes. Plant Cell Physiol. 52,
2157-2172.
Masuda, S., Harada, J., Yokono, M., Yuzawa, Y., Shimojima. M., Murofushi, K., Tanaka, H., Masuda,
H., Murakawa, M., Haraguchi, T., Kondo, M., Nishimura, M., Yuasa, H., Noguchi, M., Oh-oka, H.,
Tanaka, A., Tamiaki, H., and Ohta, H. (2011). A monogalactosyldiacylglycerol synthase found in thegreen sulfur bacterium Chlorobaculum tepidum reveals important roles for galactolipids inphotosynthesis. Plant Cell 23, 2644-2658.
⣽⬊㛫ࢩࢢࢼࣝ㸦ᯇᯘ◊㸧
2013 ᖺ
Endo, S., Shinohara, H., Matsubayashi, Y., and Fukuda, H. (2013). A novel pollen-pistil interaction
conferring high-temperature tolerance during reproduction via CLE45 signaling. Curr. Biol. 9,1670-1676.
Ogawa-Ohnishi, M., Matsushita, W., and Matsubayashi, Y. (2013). Identification of threehydroxyproline O-arabinosyltransferases in Arabidopsis thaliana. Nature Chem. Biol. 9, 726-730.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Okamoto, S., Shinohara, H., Mori, T., Matsubayashi, Y.,* and Kawaguchi, M.* (co-corresponding
authors) (2013). Root-derived CLE glycopeptides control nodulation by direct binding to HAR1
receptor kinase. Nature Commun. 4, 2191. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Shinohara, H., and Matsubayashi, Y. (2013). Chemical synthesis of Arabidopsis CLV3 glycopeptide
reveals the impact of hydroxyproline arabinosylation on peptide conformation and activity. Plant Cell
Physiol. 54, 369-374.
2012 ᖺ
Shinohara, H., Moriyama, Y., Ohyama, K., and Matsubayashi, Y. (2012). Biochemical mapping of aligand-binding domain within Arabidopsis BAM1 reveals diversified ligand recognition mechanisms ofplant LRR-RKs. Plant J. 70, 845-854.
⚄⤒⣽⬊⏕≀Ꮫ㸦᳝ྡ㸧

− 132 −

⣽⬊♫఍Ꮫ㸦℈⏣㸧
2013 ᖺ
Gasperowicz, M., Surmann-Schmitt, C., Hamada, Y., Otto, F., and Cross, J.C. (2013). The transcriptional
co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in themouse placenta. Dev. Biol. 382, 1-14.
ᙧែᙧᡂ㸦ୖ㔝◊㸧
2013 ᖺ
Hara, Y., Nagayama, K., Yamamoto, T.S., Matsumoto, T., Suzuki, M., and Ueno, N. (2013).
Directional migration of leading-edge mesoderm generates physical forces: Implication in Xenopus
notochord formation during gastrulation. Dev. Biol. 382, 482-495.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Paemka, L., Mahajan, V.B, Skeie, J.M., Sowers, L.P., Ehaideb, S.N., Gonzalez-Alegre, P., Sasaoka, T.,
Tao, H., Miyagi, A., Ueno, N., Takao, K., Miyakawa, T., Wu, S., Darbro, B.W., Ferguson, P.J., Pieper,
A.A., Britt, J.K., Wemmie, J.A., Rudd, D.S., Wassink, T., El-Shanti, H., Mefford, H.C., Carvill, G.L.,
Manak, J.R., and Bassuk, A.G. (2013). PRICKLE1 interaction with SYNAPSIN I reveals a role inautism spectrum disorders. PLoS One 8, e80737.
Suzuki, M.M., Yoshinari, A., Obara, M., Takuno, S., Shigenobu, S., Sasakura, Y., Kerr, A.R., Webb, S.,
Bird, A., and Nakayama, A. (2013). Identical sets of methylated and nonmethylated genes in Ciona
intestinalis sperm and muscle cells. Epigenetics Chromatin 6, 38.
Uno, Y., Nishida, C., Takagi, C., Ueno, N., and Matsuda, Y. (2013). Homoeologous chromosomes of
Xenopus laevis are highly conserved after whole-genome duplication. Heredity 111, 430-436.
2012 ᖺ
Leblond, G.G., Sarazin, H., Li, R., Suzuki, M., Ueno, N., and Liu. X. J. (2012). Translation of incenp
during oocyte maturation is required for embryonic development in Xenopus laevis. Biol. Reprod. 86,
161, 1-8.
Morita, H., Kajiura-Kobayashi, H., Takagi, C., Yamamoto, T.S., Nonaka, S., and Ueno, N. (2012). Cell
movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Development 139, 1417-1426. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫࢆᥖ㍕㸧
Sakamaki, K., Takagi, C., Kitayama, A., Kurata, T., Yamamoto, T.S., Chiba, K., Kominami, K., Jung,
S.K., Okawa, K., Nozaki, M., Kubota, H.Y., and Ueno, N. (2012). Multiple functions of FADD in
apoptosis, NF-ț%-related signaling, and heart development in Xenopus embryos. Genes Cells 17,875-896.
Tao, H., Inoue, K., Kiyonari, H., Bassuk, A.G., Axelrod, J.D., Sasaki, H., Aizawa, S., and Ueno, N.
(2012). Nuclear localization of Prickle2 is required to establish cell polarity during early mouseembryogenesis. Dev. Biol. 364, 138-148.
Tran, L.D., Hino, H., Quach, H., Lim, S., Shindo, A. Mimori-Kiyosue, Y., Mione, M., Ueno, N., Winkler,C., Hibi, M., and Sampath, K. (2012). Dynamic microtubules at the vegetal cortex predict the embryonicaxis in zebrafish. Development 139, 3644-3652.
Uno, Y., Nishida, C., Tarui, H., Ishishita, S., Takagi, C., Nishimura, O., Ishijima, J., Ota, H., Kosaka, A.,
Matsubara, K., Murakami, Y., Kuratani, S., Ueno N., Agata, K., and Matsuda, Y. (2012). Inference of theProtokaryotypes of Amniotes and Terapods and the Evolutionary Processes of Microchromosomes from
Comparative Gene Mapping. PLoS ONE 7, e53027.
2011 ᖺ
Endo, T., Ueno, K., Yonezawa, K., Mineta, K., Hotta, K., Satou, Y., Yamada, L., Ogasawara, M.,
Takahashi, H., Nakajima, A., Nakachi, M., Nomura, M., Yaguchi, J., Sasakura, Y., Yamasaki, C., Sera,
M., Yoshizawa, A., Imanishi, T., Taniguchi, H., and Inaba, K. (2011). CIPRO 2.5: Ciona intestinalis
protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses andcurated annotation, with user rating and reviewing functionality. Nucleic Acids Res. 39, D807-D814.

− 133 −

Takebayashi-Suzuki, K., Kitayama, A., Terasaka-Iioka, C., Ueno, N., and Suzuki, A. (2011). The
forkhead transcription factor FoxB1 regulates the dorsal-ventral and anterior-posterior patterning of theectoderm during early Xenopus embryogenesis. Dev Biol. 360, 11-29.
Tao, H., Manak, J. R., Sowers, L., Mei, X., Kiyonari, H., Abe, T., Dahdaleh, N. S., Yang, T., Wu, S.,
Chen, S., Fox, M. H., Gurnett, C., Montine, T., Bird, T., Shaffer, L. G., Rosenfeld, J. A., McConnell, J.,
Madan-Khetarpal, S., Berry-Kravis, E., Griesbach, H., Saneto, R. P., Scott, M. P., Antic, D., Reed, J.,
Boland, R., Ehaideb, S. N., El-Shanti, H., Mahajan, V. B., Ferguson, P. J., Axelrod, J. D., Lehesjoki, A.
E., Fritzsch, B., Slusarski, D. C., Wemmie, J., Ueno, N., and Bassuk, A. G. (2011). Mutations in prickle
orthologs cause seizures in flies, mice, and humans. Am. J. Hum. Genet. 88:138-49.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Yamada, S., Ueno, N., Satoh, N., and Takahashi, H. (2011). Ciona intestinalis Noto4 contains aphosphotyrosine interaction domain and is involved in the midline intercalation of notochord cells. Int. J.
Dev. Biol. 55, 11-18.
Ⓨ⏕㑇ఏᏛ㸦ᑠᯘ◊㸧
2013 ᖺ
Hira, S., Okamoto, T., Fujiwara, M., Kita, H., Kobayashi, S., and Mukai, M. (2013). Binding ofDrosophila maternal Mamo protein to chromatin and specific DNA sequences. Biochem. Biophys. Res.
Commun. 438, 156-160.
Dejima, K., Takemura, M., Nakato, E., Peterson, J., Hayashi, Y., Kinoshita-Toyoda, A., Toyoda, H.,
and Nakato, H. (2013). Analysis of Drosophila glucuronyl C5-epimerase: implications fordevelopmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. J.
Biol. Chem. 288, 34384-34393.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Lim, R., Anand, A., Nishimiya-Fujisawa, C., Kobayashi, S., and Kai, T. Analysis of Hydra PIWI proteinsand piRNAs uncover early evolutionary origins of the piRNA pathway. Dev. Biol. 2013 Dec. 16.
2012 ᖺ
Hayashi, Y., Sexton, T.R., Dejima, K., Perry, D.W., Takemura, M., Kobayashi, S., Nakato, H., andHarrison, D.A. (2012). Glypicans regulate JAK/ STAT signaling and distribution of the Unpaired
morphogen. Development 139, 4162-4171. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Nishimiya-Fujisawa, C., and Kobayashi, S. (2012). Germline stem cells and sex determination in Hydra.
Int. J. Dev. Biol. 56, 499-508.
Ohhara, Y., Kayashima, Y., Hayashi, Y., Kobayashi, S., and Yamakawa-Kobayashi, K. (2012).
Expression of beta-adrenergic-like octopamine receptors during Drosophila development. Zool. Sci., 29,
83-89.
2011 ᖺ
Hashiyama, K., Hayashi, Y. and Kobayashi, S. (2011) Drosophila Sex lethal gene initiates female
development in germline progenitors. Science 333, 885-888. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
This is highlighted in "This week in Science" (Science 333, 801), "Perspectives" (Science 333, 829-839),
and "World of Reproductive Biology" (Biology of Reproduction 85, 427-428).
Mukai, M., Kato, K., Hira, S., Nakamura, K., Kita H. and Kobayashi S. (2011) Innexin2 gap junctions insomatic support cells are required for cyst formation and for egg chamber formation in Drosophila. Mech.
Dev., 128, 510-523.
ศᏊⓎ⏕Ꮫ㸦㧗⏣◊㸧
2013 ᖺ
Hira, S., Okamoto, T., Fujiwara, M., Kita, H., Kobayashi, S., and Mukai, M. (2013). Binding ofDrosophila maternal Mamo protein to chromatin and specific DNA sequences. Biochem. Biophys. Res.
Commun. 438, 156-160.

− 134 −

Dejima, K., Takemura, M., Nakato, E., Peterson, J., Hayashi, Y., Kinoshita-Toyoda, A., Toyoda, H.,
and Nakato, H. (2013). Analysis of Drosophila glucuronyl C5-epimerase: implications fordevelopmental roles of heparan sulfate sulfation compensation and 2-O-sulfated glucuronic acid. J.
Biol. Chem. 288, 34384-34393.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Lim, R., Anand, A., Nishimiya-Fujisawa, C., Kobayashi, S., and Kai, T. Analysis of Hydra PIWI proteinsand piRNAs uncover early evolutionary origins of the piRNA pathway. Dev. Biol. 2013 Dec. 16.
2012 ᖺ
Chen, Q., Takada, R., and Takada, S. (2012). Loss of Porcupine impairs convergent extension during
gastrulation in zebrafish. J. Cell Sci. 125, 2224-2234.
Chiu, C.H., Chou, C.W., Takada, S., and Liu, Y.W. (2012). Development and fibronectin signaling
requirements of the zebrafish interrenal vessel. PLoS ONE 7, e43040.
Yabe, T., and Takada,, S. (2012). Mesogenin causes embryonic mesoderm progenitors to differentiate
during development of zebrafish tail somites. Dev. Biol. 370, 213-222.
2011 ᖺ
Okubo, T., Kawamura, A.,Takahashi, J., Yagi, H., Morishima, M., Matsuoka, R., & Takada, S. (2011)
Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its derivatives inmice. Development 138, 339-348. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
ึᮇⓎ⏕㸦⸨᳃◊㸧
2013 ᖺ
Abe, T., Sakaue-Sawano, A., Kiyonari, H., Shioi, G., Inoue, K., Horiuchi, T., Nakao, K., Miyawaki, A.,
Aizawa, S., and Fujimori, T. (2013). Visualization of cell cycle in mouse embryos with Fucci2 reporter
directed by Rosa26 promoter. Development 140, 237-246.
Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y.,
Ota, K., Oda, K., et al. (2013). TAG-1-assisted progenitor elongation streamlines nuclear migration to
optimize subapical crowding. Nature Neurosci. 16, 1556-1566.
Xu, G., Shen, J., Ishii, Y., Fukuchi, M., Dang, T.C., Zheng, Y., Hamashima, T., Fujimori, T., Tsuda,M., Funa, K., et al. (2013). Functional analysis of platelet-derived growth factor receptor-beta in neural
stem/progenitor cells. Neuroscience 238, 195-208.
2012 ᖺBashar, K., Komatsu, K., Fujimori, T., and Kobayashi, T. J. (2012). Automatic extraction of nuclei
centroids of mouse embryonic cells from fluorescence microscopy images. PLoS ONE 7, e35550.
Cao, L., Kobayakawa, S., Yoshiki, A., and Abe, K. (2012). High resolution intravital imaging ofsubcellular structures of mouse abdominal organs using a microstage device. PLoS ONE 7, e33876.
Koyama, H., Umeda, T., Nakamura, K., Higuchi,T., and Kimura, A. (2012). A high-resolution shapefitting and simulation demonstrated equatorial cell surface softening during cytokinesis and its promotive
role in cytokinesis. PLoS ONE 7, e31607.
2011 ᖺ
Abe, T., Kiyonari, H., Shioi, G., Inoue, K., Nakao, K., Aizawa, S., Fujimori, T. (2011). Establishment ofconditional reporter mouse lines at ROSA26 locus for live cell imaging. Genesis 49, 579-90.
Nakagawa, T., Izumino, K., Ishii, Y., Oya, T., Hamashima, T.,Jie, S., Tomoda, F., Fujimori, T.,
Nabeshima, Y., Inoue, H., Sasahara, M. (2011). Roles of PDGF receptor-beta in the structure andfunction of postnatal kidney glomerulus. Nephrol Dial. Transplant. 26, 458-68.
Shi, D., Komatsu, K., Uemura, T., Fujimori, T. (2011). Analysis of ciliary beat frequency and ovum
transport ability in the mouse oviduct. Genes to Cells 16, 282-90.
Shioi, G., Kiyonari, H., Abe, T., Nakao, K., Fujimori, T., Jang, C., Huang, C., Akiyama, H., Behringer,− 135 −

R., R., Aizawa, S. (2011). A mouse reporter line to conditionally mark nuclei and cell membranes forin vivo live-imaging. Genesis 49, 570-78.

⏕Ṫ⣽⬊㸦ྜྷ⏣◊㸧
2013 ᖺ
Nakamura, Y., Tasai, M., Takeda, K., Nirasawa, K., and Tagami, T. (2013). Production of functional
gametes from cryopreserved primordial germ cells of the Japanese quail. J Reprod. Dev. 59, 580-587.
Nonami, Y., Narita, K., Nakamura, H., Inoue, T., and Takeda, S. (2013). Developmental changes inciliary motility on choroid plexus epithelial cells during the perinatal period. Cytoskeleton (Hoboken)
70, 797-803.
Shirakawa, T., Yaman-Deveci, R., Tomizawa, S., Kamizato, Y., Nakajima, K., Sone, H., Sato, Y.,
Sharif, J., Yamashita, A., Takada-Horisawa, Y., Yoshida, S., Ura, K., Muto, M., Koseki, H., Suda, T.,
and Ohbo, K. (2013). An epigenetic switch is crucial for spermatogonia to exit the undifferentiatedstate toward a Kit-positive identity. Development 140, 3565-3576.
2012 ᖺ
Koyanagi, S., Hamasaki, H., Sekiguchi, S., Hara, K., Ishii, Y., Kyuwa, S., and Yoshikawa, Y. (2012).
Effects of ubiquitin C-terminal hydrolase L1 deficiency on mouse ova. Reproduction 143, 271-279.
Nakamura, Y., Usui, F., Miyahara, D., Mori, T., Ono, T., Kagami, H., Takeda, K., Nirasawa, K., andTagami, T. (2012). X-irradiation Removes Endogenous Primordial Germ Cells (PGCs) and Increases
Germline Transmission of Donor PGCs in Chimeric Chickens. J. Reprod. Dev. 58, 432-437.
Sato, T., Yokonishi, T., Komeya, M., Katagiri, K., Kubota, Y., Matoba, S., Ogonuki, N., Ogura, A.,
Yoshida, S., and Ogawa, T. (2012). Testis tissue explantation cures spermatogenic failure in c-Kit ligand
mutant mice. Proc. Natl. Acad. Sci. USA 109, 16934-16938.
Sugimoto, R., Nabeshima, Y., and Yoshida, S. (2012). Retinoic acid metabolism links the periodical
differentiation of germ cells with the cycle of Sertoli cells in mouse seminiferous epithelium. Mech. Dev.
128, 610-624.
2011 ᖺ
Sato, T., Aiyama, Y., Ishii-Inagaki, M., Hara, K., Tsunekawa, N., Harikae, K., Uemura-Kamata, M.,
Shinomura, M., Zhu, X. B., Maeda, S., Kuwahara-Otani, S., Kudo, A., Kawakami, H., Kanai-Azuma, M.,
Fujiwara, M., Miyamae, Y., Yoshida, S., Seki, M., Kurohmaru, M., and Kanai. Y. (2011) Cyclical andpatch-like GDNF distribution along the basal surface of sertoli cells in mouse and hamster testes. PLoS
ONE 6, e28367.

⏕Ṫ⏕≀Ꮫ㸦㛗℈◊㸧
2011 ᖺ
Charkraborty, T., Shibata, Y., Zhou, L.Y., Katsu, Y., Iguchi, T. and Nagahama, Y. (2011). Differential
expression of three estrogen receptor subtype mRNAs in gonads and liver from embryos to adults ofthe medaka, Oryzias latipes. Mol. Cell. Endocrinol. 333, 47-54.
Charkraborty, T., Katsu, Y., Zhou, L.Y., Miyagawa, S., Nagahama, Y. and Iguchi, T. (2011). Estrogen
receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: An in vitro-in vivo
correlation. J. Steroid Biochem. Mol. Biol. 123, 115-121.
Fernandino, J.I., Popesku, J.T., Paul-Prasanth, B., Xiong, H., Hattori, R.S., Oura, M., Strussmann, C.A.,
Somoza, G.M., Matsuda, M., Nagahama, Y. and Trudeau, V.L. (2011). Analysis of sexually dimorphic
expression of genes at early gonadogenesis of Pejerrey Odontesthes bonariensis uing a heterologous
microarray. Sex. Dev. 5, 89-101.
Mita, M., Yamamoto, K., Nakamura, M. and Nagahama, Y. (2011). Hormonal action of relaxin-likegonad-stimulating substance (GSS) on starfish ovaries in growing and fully grown states. Gen. Comp.
Endocrinol. 172, 85-89− 136 −

Mita, M., Yamamoto, K. and Nagahama, Y. (2011). Interaction of relaxin-like gonad-stimulating
substance with ovarian follicle cells of the starfish Asterina pectinifera. Zool. Sci. 28, 764-769.
Ngamniyom, A., Magtoon, W., Nagahama, Y. and Sasayama, Y. (2011). Expression levels of bonemorphogenetic protein 2b in fins of adult Japanese medaka (Oryzias latipes) exposed to sex steroid
hormones. J. Fish. Aquat. Sci. 6, 119-129.
Okubo, K., Takeuchi, A., Chaube, R., Paul-Prasanth, B., Kanda, S., Oka, Y. and Nagahama, Y. (2011).
Sex differences in aromatase gene expression in the medaka brain. J. Neuroendocrinology 23, 412-423.
Paul-Prasanth, B., Shibata, Y., Horiguchi, R. and Nagahama, Y. (2011). Exposure to diethylstilbesterol
during embryonic and larval stages of medaka fish (Oryzias latipes) leads to sex reversal in genetic
males and reduced gonad weight in genetic females. Endocrinology 152, 707-717.
Raghuveer, K., Sudhakumari, C.C., Senthilkumaran, B., Kagawa, H., Dutta-Gupta, A. and Nagahama,Y. (2011). Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. Gen.
Comp. Endocrinol. 171, 94-104.
⏕Ṫ㑇ఏᏛ㸦⏣୰ G㸧
2013 ᖺ
Kobayashi, K., Kamei, K., Kinoshita, M., Czerny, T., and Tanaka, M. (2013). A heat-inducible
cre/loxP gene induction system in medaka. Genesis 51, 59-67.
Ishikawa, T., Okada, T., Ishikawa-Fujisawa, T., Todo, T., Kamei, Y., Shigenobu, S., Tanaka, M., Saito,
T.L., Yoshimura, J., Morishita, S., Toyoda, A., Sakaki, Y., Taniguchi, Y., Takeda, S., and Mori, K.
(2013). ATF6a/b-mediated adjustment of ER chaperone levels is essential for development of thenotochord in medaka fish. Mol. Biol. Cell. 24, 1387-1395.
Herpin, A., Adolfi, M.C., Nicol, B., Hinzmann, M., Schmidt, C., Klughammer, J., Engel, M., Tanaka,
M., Guiguen, Y., and Schartl, M.͒(2013). Divergent expression regulation of gonad development genes
in medaka shows incomplete conservation of the downstream regulatory network of vertebrate sex
determination. Mol. Biol. Evol. 30, 2328-2346.
2012 ᖺ
Ichimura, K., Bubenshchikova, E., Powell, R., Fukuyo, Y., Nakamura, T., Tran, U., Oda, S., Tanaka, M.,
Wessely, O., Kurihara, H., Sakai, T., and Obara, T. (2012). A comparative analysis of glomerulus
development in the pronephros of medaka and zebrafish. PLoS ONE 7, e45286.
Nakamura, S., Watanabe, I., Nishimura, T., Picard, J-Y., Toyoda, A., Taniguchi, Y., di Clemente, N., andTanaka, M. (2012). Hyperproliferation of mitotically active germ cells dues to defective anti-Müllerian
hormone signaling mediates sex reversal in medaka. Development 139, 2283-2287.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Nakamura, S., Watanabe, I., Nishimura, T., Toyoda, A., Taniguchi, Y., and Tanaka, M. (2012). Analysisof medaka sox9 orthologue reveals a conserved role in germ cell maintenance. PLoS ONE 7, e29982.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

2011 ᖺ
Hano, T., Oshima, Y., Kinoshita, M., Tanaka, M., Mishima, N., Wakamatsu, Y., Ozato, K., Shimasaki, Y.
and Honjo, T. (2011). Evaluation of the effects of ethinylestradiol on sexual differentiation in theolvas-GFP/STII-YI medaka (transgenic Oryzias latipes) strain as estimated by proliferative activity ofgerm cells. Aquatic Toxicol. 104, 177-184.
᳜≀ჾᐁᙧᡂᏛ㸦ᒸ⏣ඖᡤ㛗◊㸧
2013 ᖺ
Miyashima, S., Honda, M., Hashimoto, K., Tatmeatsu, K., Hashimoto, T., Sato-Nara, K., Okada, K.,
and Nakajima, K. (2013). A comprehensive expression analysis of Arabidopsis MICRORNA165/6 gene

− 137 −

family in embryogenesis revealed a conserved role innon-cell-autonomous function. Plant Cell Physiol. 54, 375-384.

meristem

specification

anda

Takeda, S., Iwasaki, A., Matsumoto, N., Tatematsu, K., and Okada, K. (2013). Physical interaction
between floral organs controls petal morphogenesis in Arabidopsis thaliana. Plant Physiol. 161,
1242-1250.
Ikeuchi, M., Tatematsu, K., Yamaguchi, T., Okada, K., and Tsukaya, H. (2013). Precocious
progression of tissue maturation instructs basipetal initiation of leaflets in Chelidonium majus subsp.
asiaticum (Papaveraceae). Am. J. Bot. 100, 1116-1126.
Tameshige, T., Fujita, H., Watanabe, K., Toyokura, K., Kondo, M., Tatematsu, K., Matsumoto, N.,
Tsugeki, R., Kawaguchi, M., Nishimura, M., and Okada, K. (2013). Pattern dynamics inadaxial-abaxial specific gene expression are modulated by a plastid retrograde signal during
Arabidopsis leaf development. PLoS Genetics 9, e1003655. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
2012 ᖺ
Endo, A.*, Tatematsu, K.*, Hanada, K.*, Duermeyer, L., Okamoto, M., Yonekura-Sakakibara, K.,
Saito, K., Toyoda, T., Kawakami, N., Kamiya, Y., Seki, M., and Nambara, E. (2012). Tissue-specifictranscriptome analysis reveals cell wall metabolism, flavonol biosynthesis, and defense responses areactivated in the endosperm of germinating Arabidopsis thaliana seeds. Plant Cell Physiol. 53, 16-27.
(*: Equally contributed)
Nakata, M., Matsumoto, N., Tsugeki, R., Rikirsch, E. Laux, T., and Okada, K. (2012). Roles of the
middle domain-specific WUSCHEL-RELATED-HOMEOBOX genes in early development of leaves in
Arabidopsis. Plant Cell 24, 519-535. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Nakata, M., and Okada, K. (2012). The three-domain model: A new model for the early developmentof leaves in Arabidopsis thaliana. Plant Signal. Behav. 7, 1423-1427.
Sakai, T., Mochizuki, S., Haga, K., Uehara, Y., Suzuki, A., Harada, A., Wada, T., Ishiguro, S., andOkada, K. (2012). The WAVY GROWTH 3 E3 ligase family controls the gravitropic responses in
Arabidopsis root. Plant J. 70, 303-314.
Toyokura, K., Hayashi, M., Nishimura, M., and Okada, K. (2012). Adaxial-abaxial patterning: A novel
function of the GABA shunt. Plant Signal. Behav. 7, 705-707.
2011 ා
Toyokura, K., Watanabe, K., Oikawa, A., Kusano, M., Tameshige, T., Tatematsu, K., Matsumoto, N.,
Tsugeki, R., Saito, K., and Okada, K. (2011) Succinic semialdehyde dehydrogenase is involved in therobust patterning of Arabidopsis leaves along the adaxial-abaxial axis. Plant Cell Physiol. 52, 1340-1353.
Ueda, M., Matsui, K., Ishiguro, S., Kato, T., Tabata, S., Kobayashi, M., Seki, M., Shinozaki, K., andOkada, K. (2011) Arabidopsis RPT2a encoding the 26S proteasome subunit is required for various
aspects of root meristem maintenance, and regulates gametogenesis redundantly with its homolog,
RPT2b. Plant Cell Physiol. 52, 1628-1640.
⤫ྜ⚄⤒⏕≀Ꮫ㸦㔝⏣◊㸧
2013 ᖺ
Ayoub, E., Hall, A., Scott, A.M., Chagnon, M.J., Miquel, G., Hallé, M., Noda, M., Bikfalvi, A., andTremblay, M.L. (2013). Regulation of the Src kinase-associated phosphoprotein 55 homologue by theprotein tyrosine phosphatase PTP-PEST in the control of cell motility. J. Biol. Chem. 288, 25739-25748.
Hiyama, T.Y., Yoshida, M., Matsumoto, M., Suzuki, R., Matsuda, T., Watanabe, E., and Noda, M.
(2013). Endothelin-3 expression in the subfornical organ enhances the sensitivity of Nax, the brain
sodium-level sensor, to suppress salt intake. Cell Metabolism 17, 507-519.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Sakuraba, J., Shintani, T., Tani, S., and Noda, M. (2013). Substrate specificity of R3 receptor-likeprotein-tyrosine phosphatase subfamily towards receptor protein-tyrosine kinases. J. Biol. Chem. 288,
23421-23431.㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

− 138 −

Yonehara, K., Farrow, K., Ghanem, A., Hillier, D., Balint, K., Teixeira, M., Jüttner, J., Noda, M., Neve,
R.L., Conzelmann, K.-K., and Roska, B. (2013). The first stage of cardinal direction selectivity is
localized to the dendrites of retinal ganglion cells. Neuron 79, 1078-1085.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Unezaki, S., Katano, T., Hiyama, T.Y., Tu, N.H., Yoshii, S., Noda, M., and Ito, S. Involvement of Nax
sodium channel in peripheral nerve regeneration via lactate signaling. Eur. J. Neurosci. 2013 Nov. 29.
2012 ා
Kuboyama, K., Fujikawa, A., Masumura, M., Suzuki, R., Matsumoto, M., and Noda, M. (2012). Protein
tyrosine phosphatase receptor type Z negatively regulates oligodendrocyte differentiation andmyelination. PLoS ONE 7, e48797. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Matsumoto, M., Fujikawa, A., Suzuki, R., Shimizu, H., Kuboyama, K., Hiyama, T.Y., Hall, R.A., andNoda, M. (2012). SAP97 promotes the stability of Nax channels at the plasma membrane. FEBS Lett. 586,
3805-3812.
Shintani, T., Takeuchi, Y., Fujikawa, A., and Noda, M. (2012). Directional neuronal migration is
impaired in mice lacking adenomatous polyposis coli 2. J. Neurosci. 32, 6468-6484.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Sugitani, K., Ogai, K., Hitomi, K., Nakamura-Yonehara, K., Shintani, T., Noda, M., Koriyama, Y., Tanii,
H., Matsukawa, T., and Kato, S. (2012). A distinct effect of transient and sustained upregulation ofcellular factor XIII in the goldfish retina and optic nerve on optic nerve regeneration. Neurochem. Int. 61,
423-432.
2011 ා
Fujikawa, A., Fukada, M., Makioka, Y., Suzuki, R., Chow, J.P., Matsumoto, M. and Noda, M. (2011).
Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J. Biol. Chem. 286,
37137-37146.
Nayak, G., Goodyear, R.J., Legan, P.K., Noda, M. and Richardson G.P. (2011). Evidence for multiple,
developmentally regulated isoforms of PTPRQ on hair cells of the inner ear. Dev. Neurobiol. 71,
129-141.
Nishihara, E., Hiyama, T.Y. and Noda, M. (2011). Osmosensitivity of transient receptor potential
vanilloid 1 is synergistically enhanced by distinct activating stimuli such as temperature and protons.
PLoS ONE 6, e22246. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Sakamoto, K., Bu, G., Chen, S., Takei, Y., Hibi, K., Kodera, Y., McCormick, L.M., Nakao, A., Noda, M.,
Muramatsu, T., and Kadomatsu, K. (2011). The premature ligand-receptor interaction during biosynthesis
limits the production of growth factor midkine and its receptor LDL receptor-related protein 1 (LRP1). J.
Biol. Chem. 286, 8405-8413.
Yonehara, K., Balint, K., Noda, M., Nagel, G., Bamberg, E., and Roska, B. (2011). Spatiallyasymmetric reorganization of inhibition establishes a motion-sensitive circuit. Nature 469, 407-410.
⬻⏕≀Ꮫ㸦ᒣ᳃◊㸧
2013 ᖺ
Hata, K., Mizukami, H., Sadakane, O., Watakabe, A., Ohtsuka, M., Takaji, M., Kinoshita, M., Isa, T.,
Ozawa. K., and Yamamori, T. (2013). DNA methylation and methyl-binding proteins control
differential gene expression in distinct cortical areas of macaque monkey. J. Neurosci. 33,
19704-19714. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Nakagami, Y., Watakabe, A., and Yamamori, T. (2013). Monocular inhibition reveals temporal andspatial changes in gene expression in the primary visual cortex of marmoset. Front. Neural Circuits. 7,
43. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Moritoh, S., Komatsu, Y., Yamamori, T., and Koizumi, A. (2013). Diversity of retinal ganglion cells
identified by transient GFP transfection in organotypic tissue culture of adult marmoset monkey retina.

− 139 −

PLoS ONE 8, e54667. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
2012 ᖺ
Kinoshita, M., Matsui, R., Kato, S., Hasegawa, T., Kasahara, H., Isa, K., Watakabe, A., Yamamori, T.,
Nishimura, Y., Alstermark, B., Watanabe, D., Kobayashi, K., and Isa, T. (2012). Genetic dissection of thecircuit for hand dexterity in primates. Nature 487, 235-238.
Komine, Y., Takao, K., Miyakawa, T., and Yamamori, T. (2012). Behavioral abnormalities observed in
zfhx2-deficient mice. PLoS ONE 7, e53114.
Takahata, T., Shukla, R., Yamamori, T., and Kaas, J.H. (2012). Differential expression patterns of striate
cortex-enriched genes among Old World, New World, and prosimian primates. Cereb. Cortex 22,
2313-2321.
Watakabe, A., Hirokawa, J., Ichinohe, N., Ohsawa, S., Kaneko, T., Rockland, K.S., and Yamamori, T.
(2012). Area-specific substratification of deep layer neurons in the rat cortex. J. Comp. Neurol. 520,
3553-3573.
Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H.,
Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura, Y., and Yamamori, T. (2012). Visualizationof cortical projection neurons with retrograde TET-off lentiviral vector. PLoS ONE 7, e46157.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕

2011 ᖺ
Hirokawa, J., Sadakane, O., Sakata, S., Bosch, M., Sakurai, Y., Yamamori, T. (2011) Multisensory
information facilitates reaction speed by enlarging activity difference between superior colliculus
hemispheres in rats. PLoS ONE 2011, 6, e25283.
Kitsukawa, T., Nagata, M., Yanagihara, D., Tomioka, R., Utsumi, H., Kubota, Y., Yagi, T., Graybiel,A.M., Yamamori, T. (2011) A novel instrumented multipeg running wheel system, Step-Wheel, formonitoring and controlling complex sequential stepping in mice. J Neurophysiol. 106, 479-487.
Rossini, L., Moroni. R.F., Tassi, L., Watakabe, A., Yamamori, T., Spreafico, R., and Garbelli, R. (2011).
Altered layer-specific gene expression in cortical samples from patients with temporal lobe epilepsy.
Epilepsia 52, 1928-1937.
ග⬻ᅇ㊰㸦ᯇᓮ◊㸧
2013 ᖺ
Hira, R., Ohkubo, F., Ozawa, K., Isomura, Y., Kitamura, K., Kano, M., Kasai, H., and Matsuzaki, M.
(2013). Spatiotemporal dynamics of functional clusters of neurons in the mouse motor cortex during a
voluntary movement. J. Neurosci. 33, 1377-1390. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Hira, R., Ohkubo, F., Tanaka, Y.R., Masamizu, Y., Augustine, G.J., Kasai, H., and Matsuzaki, M.
(2013). In vivo optogenetic tracing of functional corticocortical connections between motor forelimbareas. Front. Neural Circuits 7, 55.
Asrican, B., Augustine, G.J., Berglund, K., Chen, S., Chow, N., Deisseroth, K., Feng, G., Gloss, B.,
Hira, R., Hoffmann, C., Kasai, H., Katarya, M., Kim, J., Kudolo, J., Lee, L., Lo, S., Mancuso, J.,
Matsuzaki, M., Nakajima, R., Qui, L., Tan, G., Tang, Y., Ting, J.T., Tsuda, S., Wen, L., Zhang, X., andZhao, S. (2013). Next-generation transgenic mice for optogenetic analysis of neural circuits. Front.
Neural Circuits 7, 160.
Hayama, T., Noguchi, J., Watanabe, S., Takahashi, N., Hayashi-Takagi, A., Ellis-Davies, G.C.R.,
Matsuzaki, M., and Kasai, H. (2013). GABA promotes the competitive selection of dendritic spines bycontrolling local Ca2+ signaling. Nature Neurosci. 16, 1409-1416.
2012 ᖺ
Kimura, R., Saiki, A., Fujiwara-Tsukamoto, Y., Ohkubo, F., Kitamura, K., Matsuzaki, M., Sakai, Y., andIsomura, Y. (2012). Reinforcing operandum: rapid and reliable learning of skilled forelimb movements
by head-fixed rodents. J. Neurophysiol. 108, 1781-1792.

− 140 −

2011 ᖺAko, R., Wakimoto, M., Ebisu, H., Tanno, K., Hira, R., Kasai, H., Matsuzaki, M. and Kawasaki H.
(2011). Simultaneous visualization of multiple neuronal properties with single-cell resolution in theliving rodent brain. Mol. Cell. Neurosci. 48, 246-257.
Kanemoto, Y., Matsuzaki, M., Morita, S., Hayama, T., Noguchi, J., Senda, N., Momotake, A., Arai, T.,
and Kasai, H. (2011). Spatial distributions of GABA receptors and local inhibition of Ca2+ transients
studied with GABA uncaging in the dendrites of CA1 pyramidal neurons. PLoS ONE 6, e22652.
Matsuzaki, M., Ellis-Davies, G.C.R., Kanemoto, Y. and Kasai, H. (2011). Simultaneous two-photon
activation of presynaptic cells and calcium imaging in postsynaptic dendritic spines. Neural Syst. Circuits
1: 2.
Matsuzaki M., and Kasai H. Two-Photon Uncaging Microscopy. (2011). Cold Spring Harbor Protocols,
pdb.prot5620, 2011.
Noguchi, J., Nagaoka, A., Watanabe, S., Ellis-Davies, G.C.R., Kitamura, K., Kano, M., Matsuzaki, M.,
and Kasai, H. (2011). In vivo two-photon uncaging of glutamate revealing the structure-function
relationships of dendritic spines in the neocortex of adult mice. J. Physiol. 589, 2447-2457.
⚄⤒⏕⌮Ꮫ㸦Ώ㎶ G㸧
2013 ᖺ
Hiyama, T.Y., Yoshida M., Matsumoto, M., Suzuki, R., Matsuda, T., Watanabe, E., and Noda, M.
(2013). Endothelin-3 expression in the subfornical organ enhances the sensitivity of Nax, the brain
sodium-level sensor, to suppress salt intake. Cell Metabolism 17, 507-519.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕

2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧Nakayasu, T., and Watanabe, E. Biological motion stimuli are attractive to medaka fish. Animal
Cognition 2013 Oct. 20. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
2012 ᖺ
Matsunaga, W., and, Watanabe, E. (2012). Visual motion with pink noise induces predation behaviour,
Scientific Reports, 2, 219.㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕⏕≀㐍໬㸦㛗㇂㒊◊㸧
2013 ᖺ
Kim, S.Y., Colpitts, C.C., Wiedemann, G., Jepson, C., Rahimi, M., Rothwell, J.R., McInnes, A.D.,
Hasebe, M., Reski, R., Sterenberg, B.T., et al. (2013). Physcomitrella PpORS, basal to plant type III
polyketide synthases in phylogenetic trees, is a very long chain 2'-oxoalkylresorcinol synthase. J. Biol.
Chem. 288, 2767-2777.
Kubo, M., Imai, A., Nishiyama, T., Ishikawa, M., Sato, Y., Kurata, T., Hiwatashi, Y., Reski, R., andHasebe, M. (2013). System for Stable beta-Estradiol-Inducible Gene Expression in the Moss. PLoS
ONE 8, e77356.
Murata, T., Sano, T., Sasabe, M., Nonaka, S., Higashiyama, T., Hasezawa, S., Machida, Y., andHasebe, M. (2013). Mechanism of microtubule array expansion in the cytokinetic phragmoplast.
Nature Communications 4, 1967. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Sakakibara, K., Ando, S., Yip, H.K., Tamada, Y., Hiwatashi, Y., Murata, T., Deguchi, H., Hasebe, M.,
and Bowman, J.L. (2013). KNOX2 genes regulate the haploid-to-diploid morphological transition inland plants. Science 339, 1067-1070. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Shibata, T.F., Maeda, T., Nikoh, N., Yamaguchi, K., Oshima, K., Hattori, M., Nishiyama, T., Has ebe,
M., Fukatsu, T., Kikuchi, Y., et al. (2013). Complete Genome Sequence of Burkholderia sp. Strain
RPE64, Bacterial Symbiont of the Bean Bug Riptortus pedestris. Genome Announc 1, e00441-00413.
Zimmer, A.D., Lang, D., Buchta, K., Rombauts, S., Nishiyama, T., Hasebe, M., Van de Peer, Y.,− 141 −

Rensing, S.A., and Reski, R. (2013). Reannotation and extended community resources for the genomeof the non-seed plant Physcomitrella patens provide insights into the evolution of plant gene structuresand functions. BMC Genomics 14, 498.
2012 ᖺ
Aoyama, T., Hiwatashi, Y., Shigyo, M., Kofuji, R., Kubo, M., Ito, M., and Hasebe, M. (2012). AP2-typetranscription factors determine stem cell identity in the moss Physcomitrella patens. Development 139,
3120-3129.㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Nishimura, T., Matano, N., Morishima, T., Kakinuma, C., Hayashi, K.I., Komano, T., Kubo, M., Hasebe,M., Kasahara, H., Kamiya, Y., and Koshiba, T. (2012). Identification of indole-3-acetic acid transport
inhibitors including compounds affecting cellular PIN trafficking by two chemical screening approaches
using maize coleoptile systems. Plant Cell Physiol. 53, 1671-1682.
Nishiyama, T., Miyawaki, K., Ohshima, M., Thompson, K., Nagashima, A., Hasebe, M., and Kurata, T.
(2012). Digital gene expression profiling by 5'-end sequencing of cDNAs during reprogramming in themoss Physcomitrella patens. PLOS ONE 7, e36471.
Suetsugu, N., Sato, Y., Tsuboi, H., Kasahara, M., Imaizumi, T., Kagawa, T., Hiwatashi, Y., Hasebe, M.,
and Wada, M. (2012). The KAC family of kinesin-like proteins is essential for the association ofchloroplasts with the plasma membrane in land plants. Plant Cell Physiol. 53, 1854-1865.
Zhao, N., Ferrer, J.L., Moon, H.S., Kapteyn, J., Zhuang, X., Hasebe, M., Stewart, C.N., Jr., Gang, D.R.,
and Chen, F. (2012). A SABATH Methyltransferase from the moss Physcomitrella patens catalyzes
S-methylation of thiols and has a role in detoxification. Phytochemistry 81, 31-41.
2011 ᖺ
Aya, K., Hiwatashi, Y., Kojima, M., Sakakibara, H., Ueguchi-Tanaka, M., Hasebe, M., and Matsuoka, M.
(2011). The Gibberellin perception system evolved to regulate a pre-existing GAMYB-mediated system
during land plant evolution. Nature Communications 2, 544.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕

Banks, J.A., Nishiyama, T., Hasebe, M., Bowman, J.L., Gribskov, M., dePamphilis, C., Albert, V.A.,
Aono, N., Aoyama, T., Ambrose, B.A., et al. (2011). The Selaginella genome identifies genetic changes
associated with the evolution of vascular plants. Science 332, 960-963.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕

Ishikawa, M., Murata, T., Sato, Y., Nishiyama, T., Hiwatashi, Y., Imai, A., Kimura, M., Sugimoto, N.,
Akita, A., Oguri, Y., Friedman, W.E., Hasebe, M., and Kubo, M. (2011). Physcomitrella
cyclin-dependent kinase A links cell cycle reactivation to other cellular changes during reprogramming ofleaf cells. Plant Cell 23, 2924-2938.
Motose, H., Hamada, T., Yoshimoto, K., Murata, T., Hasebe, M., Watanabe, Y., Hashimoto, T., Sakai,T., and Takahashi, T. (2011). NIMA-related kinases 6, 4, and 5 interact with each other to regulate
microtubule organization during epidermal cell expansion in Arabidopsis thaliana. Plant J. 67,
993-1005.
ඹ⏕ࢩࢫࢸ࣒㸦ᕝཱྀ◊㸧
2013 ᖺ
Suzaki, T., Kim, C.S., Takeda, N., Szczyglowski, K., and Kawaguchi, M. (2013). TRICOT encodes an
AMP1-related carboxypeptidase that regulates root nodule development and shoot apical meristem
maintenance in Lotus japonicus. Development 140, 353-361. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Okamoto, S., Shinohara, H., Mori, T., Matsubayashi, Y., and Kawaguchi, M. (2013). Root-derived
CLE glycopeptides control nodulation by direct binding to HAR1 receptor kinase. Nature Commun. 4,2191. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Suzaki, T., Ito, M., and Kawaguchi, M. (2013). Induction of localized auxin response during
spontaneous nodule development in Lotus japonicus. Plant Signal. Behav. 8, e23359.
Suzaki, T., and Kawaguchi, M. (2013). Grafting analysis indicates that malfunction of TRICOT in the− 142 −

root causes a nodulation-deficient phenotype in Lotus japonicus. Plant Signal. Behav. 8, e23497.
Murakami Y., Yokoyama H., Fukui R., and Kawaguchi, M. (2013). Downregulation of NSP2
expression in developmentally young regions of Lotus japonicus roots in response to rhizobial
Inoculation. Plant Cell Physiol. 54, 518-527.
Fujita, H., and Kawaguchi, M. 㸦 2013㸧 . Pattern formation by two-layer Turing system withcomplementary synthesis. J. Theor. Biol. 322, 33-45.
Soyano, T., Kouchi, H., Hirota, A., and Hayashi, M. (2013). NODULE INCEPTION directly targets
NF-Y subunit genes to regulate essential processes of root nodule development in Lotus japonicus.
PLoS Genet. 9, e1003352.
Takahara, M., Magori, S., Soyano, T., Okamoto, S., Yoshida C., Yano, K., Sato, S., Tabata, S.,
Yamaguchi, K., Shigenobu, S., Takeda, N., Suzaki, T., and Kawaguchi, M. (2013). TOO MUCH
LOVE, a novel kelch repeat-containing F-box protein, functions in the long-distance regulation of thelegume-Rhizobium symmbiosis. Plant Cell Physiol. 54, 433-447.
Tameshige, T., Fujita, H., Watanabe, K., Toyokura, K., Kondo, M., Tatematsu, K., Matsumoto, N.,
Tsugeki, R., Kawaguchi, M., Nishimura, M., and Okada, K. (2013). Pattern dynamics inadaxial-abaxial specific gene expression are modulated by a plastid retrograde signal during
Arabidopsis leaf development. PLoS Genet. 9, e1003655. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕
Miyata, K., Kawaguchi, M., and Nakagawa, T. (2013). Two distinct EIN2 genes cooperatively regulate
ethylene signaling in Lotus japonicus. Planct Cell Physiol. 54, 1469-1477.
Takeda, N., Tsuzuki, S., Suzaki, T., Parniske, M., and Kawaguchi, M. (2013). CERBERUS and NSP1of Lotus japonicus are common symbiosis genes that modulate arbuscular mycorrhiza development.
Plant Cell Physiol. 54, 1711-1723.
Tisserant, E., Malbreil, M., Kuo, A., Kohler, A., Symeonidi, A., Balestrini, R., Charron, P., Duensing,N., Freidit Frey, N., Gianinazzi-Pearson, V., Gilbert, B., Handa, Y., Herr, J., Hijri, M., Koul, R.,
Kawaguchi, M., Krajinski, F., Lammers, P., Masclaux, F.G., Murat, C., Morin, E., Ndikumana, S.,
Pagni, M., Petitpierre, D., Requena, N., Rosikiewicz, P., Riley, R., Saito, K., San Clemente, H.,
Shapiro, H., van Tuinen, D., Bécard, G., Bonfante, P., Paszkowski, U., Shachar-Hill, Y., Tuskan, G.A.,
Young, J.P.W., Sanders, I.R., Henrissat, B., Rensing, S.A., Grigoriev, I.V., Corradi, N., Roux, C., andMartin, F. (2013). The genome of an arbuscular mycorrhizal fungus provides insights into the oldest
plant symbiosis. Proc. Natl. Acad. Sci. USA 110, 20117-20122.
2012 ᖺ
Chen, J., Moreau, C., Liu, Y., Kawaguchi, M., Hofer, J., Ellis, N., and Chen, R. (2012). Conserved
genetic determinant of motor organ identity in Medicago truncatula and related legumes. Proc. Natl.
Acad. Sci. USA 109, 11723-11728.
Hakoyama, T., Niimi, K., Yamamoto, T., Isobe, S., Sato, S., Nakamura, Y., Tabata, S., Kumagai, H.,
Umehara, Y., Brossuleit, K., Petersen, T.R., Sandal, N., Stougaard, J., Udvardi, M.K., Tamaoki, M.,
Kawaguchi, M., Kouchi, H., and Suganuma, N. (2012). The intergral membrane protein SEN1 is required
for symbiotic nitrogen fixation in Lotus japonicus nodules. Plant Cell Physiol. 53, 225-236.
Hakoyama, T., Oi, R., Hazuma, K., Suga, E., Adachi, Y., Kobayashi, M., Akai, R., Sato, S., Fukai, E.,
Tabata, S., Shibata, S., Wu, G.J., Hase, Y, Tanaka, A., Kouchi, H., Umehara, Y., and Suganuma, N.
(2012). The SNARE Protein SYP71 expressed in vascular tissues is involved in symbiotic nitrogen
fixation in Lotus japonicus nodules. Plant Physiol. 160, 897-905.
Sandal, N., Jin, H., Rodriguez-Navarro, D.N., Temprano, F., Cvitanich, C., Brachmann, A., Sato, S.,
Kawaguchi, M., Tabata, S., Parniske, M., Ruiz-Sainz, J.E., Andersen, S.U., and Stougaard, J. (2012). A
set of Lotus japonicus Gifu x Lotus burttii recombinant inbred lines facilitate map-based cloning and
QTL mapping. DNA Research 19, 317-323.
Suzaki, T., Yano, K., Ito, M., Umehara, Y., Suganuma, N., and Kawaguchi, M. (2012). Positive andnegative regulation of cortical cell division during root nodule development in Lotus japonicus isaccompanied by auxin response. Development 139, 3997-4006.㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕ − 143 −

Takeda, N., Maekawa, T., and Hayashi, M. (2012). Nuclear localized and deregulated calcium andcalmodulin̽dependent protein kinase activates rhizobial and mycorrhizal responses. Plant Cell 24,
810-822.
2011 ᖺ
Fujita, H., Toyokura, K., Okada, K., and Kawaguchi, M. (2011) Reaction-diffusion pattern in shootapical meristem of plants. PLoS ONE 6, e18243.
Funayama-Noguchi, S., Noguchi, K., Yoshida, C., and Kawaguchi, M. (2011). Two CLE genes are
induced by phosphate in roots of Lotus japonicus. J. Plant Res. 124, 155-163.
Krusell, L., Sato, N., Fukuhara, I., Koch, B., Grossmann, C., Okamoto, S., Oka-Kira, E., Otsubo, Y.,
Aubert, G., Nakagawa, T., Sato, S., Tabata, S., Duc, G., Parniske, M., Wang, T. L., Kawaguchi, M., andStougaard, J. (2011). Clavata2 genes of pea and Lotus japonicus affect autoregulation of nodulation.
Plant Journal 65, 861-871.
Okamoto, S., Nakagawa, T., and Kawaguchi, M. (2011). Expression and functional analysis of a
CLV3-like gene in the model legume Lotus japonicus. Plant Cell Physiol. 52, 1211-1221.
Takeda, N., Haage, K., Sato, S., Tabata, S., and Parniske, M. (2011). Activation of a Lotus japonicus
subtilase gene during arbuscular mycorrhiza is dependent on the common symbiosis genes and two
cis-active promoter regions. Molecular Plant-Microbe Interactions 24, 662-670.
ᵓ㐀ከᵝᛶ㸦ඣ⋢㹅㸧ࣂ࢖࢜ࣜࢯ࣮ࢫ㸦ᡂ℩㹅㸧
2013 ᖺ
Guan, G., Yan, Y., Chen, T., Yi, M., Ni, H., Naruse, K., Nagahama, Y., and Hong, Y. (2013). Nanos3
gene targeting in medaka ES cells. Int. J. Biol. Sci. 9, 444-454.
Horiguchi, R., Nozu, R., Hirai, T., Kobayashi, Y., Nagahama, Y., and Nakamura, M. (2013).
Characterization of gonadal soma-derived factor expression during sex change in the protogynous
wrasse, Halichoeres trimaculatus. Dev. Dyn. 242, 388-399.
Kawaguchi, M., Takahashi, H., Takehana, Y., Naruse, K., Nishida, M., and Yasumasu, S. (2013).
Sub-functionalization of duplicated genes in the evolution of nine-spined stickleback hatching enzyme.
J. Exp. Zool. B Mol. Dev. Evol. 320, 140-150.
Nozu, R., Horiguchi, R., Murata, R., Kobayashi, Y., and Nakamura, M. (2013). Survival of ovariansomatic cells during sex change in the protogynous wrasse, Halichoeres trimaculatus. Fish Physiol.
Biochem. 39, 47-51.
Ohshima, A., Morimura, N., Matsumoto, C., Hiraga, A., Komine, R., Kimura, T., Naruse, K., andFukamachi, S. (2013). Effects of body-color mutations on vitality: an attempt to establish easy-to-breed
see-through medaka strains by outcrossing. G3 3, 1577-1585.
Okuyama, T., Isoe, Y., Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y.,
Shimizu, A., Kubo, T., et al. (2013). Controlled Cre/loxP site-specific recombination in the developing
brain in medaka fish, Oryzias latipes. PLoS One 8, e66597.
Paul-Prasanth, B., Bhandari, R.K., Kobayashi, T., Horiguchi, R., Kobayashi Y., Nakamoto, M., Shibata,Y., Sakai, F., Nakamura, M., and Nagahama, Y. (2013). Estrogen oversees the maintenance of thefemale genetic program in terminally differentiated gonochorists. Sci. Rep. 3, 2862.
Uno, Y., Asada, Y., Nishida, C., Takehana, Y., Sakaizumi, M., and Matsuda, Y. (2013). Divergence ofrepetitive DNA sequences in the heterochromatin of medaka fishes: molecular cytogenetic
characterization of constitutive heterochromatin in two medaka species: Oryzias hubbsi and O.
celebensis (Adrianichthyidae, Beloniformes). Cytogenet. Genome Res. 141, 212–226.

− 144 −

2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Zhang, X., Guan, G., Chen, J., Naruse, K., and Hong, Y. Parameters and efficiency of direct genedisruption by zinc finger nucleases in medaka embryos. Marine Biotech. 2013 Oct. 23.
2012 ᖺ
Chen, J., Zhang, X., Wang, T., Li, Z., Guan, G., and Hong, Y. (2012). Efficient detection, quantificationand enrichment of subtle allelic alterations. DNA Research 19, 423-433
Isoe, Y., Okuyama, T., Taniguchi, Y., Kubo, T., and Takeuchi, H. (2012), p53 Mutation suppresses adultneurogenesis in medaka fish (Oryzias latipes). Biochem. Biophys. Res. Commun. 423, 627-631.
Kimura, T., and Naruse, K. (2012). Genetic analysis of vertebral regionalization and number in Medaka(Oryzias latipes) inbred lines. G3 2, 1317-1323.
Li, J., Chen, W., Wang, D., Zhou, L., Sakai, F., Guan, G., and Nagahama, Y. (2012). GATA4 is involvedin the gonadal development and maturation of the teleost fish tilapia, Oreochromis niloticus. J. Reprod.
Dev. 58, 237-242.
Moriyama, Y., Kawanishi, T., Nakamura, R., Tsukahara, T., Sumiyama, K., Suster, M.L., Kawakami, K.,
Toyoda, A., Fujiyama, A., Yasuoka, Y., Nagao, Y., Sawatari, E., Shimizu, A., Wakamatsu, Y., Hibi, M.,
Taira, M., Okabe, M., Naruse, K., Hashimoto, H., Shimada, A., and Takeda H. (2012). The medaka
zic1/zic4 mutant provides molecular insights into teleost caudal fin evolution. Curr. Biol. 22, 601-607.
Myosho, T., Otake, H., Masuyama, H., Matuda, M., Kuroki, Y., Fujiyama, A., Naruse, K., Hamaguchi, S.,
and Sakaizumi, M. (2012). Tracing the emergence of a novel sex-determining gene in medaka, Oryzias
luzonensis. Genetics 191, 163-170.
Myosho, T., Takehana, Y., Sato, T., Hamaguchi, S., and Sakaizumi, M. (2012). The origin of the large
metacentric chromosome pair in Chinese medaka (Oryzias sinensis). Ichthyol. Res. 59, 384-388
Nakamoto, M., Fukasawa, M., Tanaka, S., Shimamori, K., Suzuki, A., Matsuda, M., Kobayashi, T.,
Nagahama, Y., Shibata, N. (2012). Expression of 3ș-hydroxysteroid dehydrogenase (hsd3b), star andad4bp/sf-1 during gonadal development in medaka (Oryzias latipes). Gen. Comp. Endocrinol. 176,
222-230.
Oshima, Y., Sato, H., Kajiura-Kobayashi, H., Kimura, T., Naruse, K., and Nonaka, S. (2012). Lightsheet-excited spontaneous Raman imaging of a living fish by optical sectioning in a wide field Raman
microscope. Optics Express 20, 16195-16204.㸦3࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Shibata, Y., Iwamatsu, T., Suzuki, N., Young, G., Naruse, K., Nagahama, Y., and Yoshikuni, M. (2012).
An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg
envelope hardening during fertilization in medaka (Oryzias latipes). Dev. Biol. 372, 239-248.
Takehana, Y., Naruse, K., Asada, Y., Matsuda, Y., Shin-I, T., Kohara, Y., Fujiyama, A., Hamaguchi, S.,
and Sakaizumi, M. (2012). Molecular cloning and characterization of the repetitive DNA sequences thatcomprise the constitutive heterochromatin of the W chromosomes of medaka fishes. Chromosome Res.
20, 71-81.
Zhao, H., Li, M., Purwanti, Y.I., Liu, R., Chen, T., Li, Z., Hong, N., Guan, G., Yin, A., Xiao, L., Ge, R.,
Song, J., and Hong, Y. (2012). Mitf is a transcriptional activator of medaka germ genes in culture.
Biochimie 94, 759-767.
2011 ᖺ
Chakraborty, T., Shibata, Y., Zhou, L.Y., Katsu, Y., Iguchi, T., and Nagahama, Y. (2011). Differential
expression of three estrogen receptor subtype mRNAs in gonads and liver from embryos to adults of the
medaka, Oryzias latipes. Molecular and Cellular Endocrinology 333, 47-54.
Kai, W., Kikuchi, K., Tohari, S., Chew, A.K., Tay, A., Fujiwara, A., Hosoya, S., Suetake, H., Naruse, K.,
Brenner, S., et al. (2011). Integration of the Genetic Map and Genome Assembly of Fugu Facilitates
Insights into Distinct Features of Genome Evolution in Teleosts and Mammals. Genome Biology and
Evolution 3, 424-442− 145 −

Kato, M., Takehana, Y., Fukuda, Y., Naruse, K., Sakaizumi, M., and Hamaguchi, S. (2011). An
autosomal locus controls sex reversal in interspecific XY hybrids of the medaka fishes. Heredity 107,523-529.
Kobayashi, H., Iwamatsu, T., Shibata, Y., Ishihara, M., and Kobayashi, Y. (2011). Effects ofco-administration of estrogen and androgen on induction of sex reversal in the medaka Oryzias latipes.
Zoolog. Sci. 28, 355-359.
Koga, A., Sasaki, S., Naruse, K., Shimada, A., and Sakaizumi, M. (2011). Occurrence of a short variantof the Tol2 transposable element in natural populations of the medaka fish. Genetics Research 93, 13-21.
Okuyama, T., Suehiro, Y., Imada, H., Shimada, A., Naruse, K., Takeda, H., Kubo, T., and Takeuchi, H.
(2011). Induction of c-fos transcription in the medaka brain (Oryzias latipes) in response to mating
stimuli. Biochemical and Biophysical Research Communications 404, 453-457.
Paul-Prasanth, B., Shibata, Y., Horiguchi, R., and Nagahama, Y. (2011). Exposure to diethylstilbestrol
during embryonic and larval stages of medaka fish (Oryzias latipes) leads to sex reversal in genetic males
and reduced gonad weight in genetic females. Endocrinology 152, 707-717.
ከᵝᛶ⏕≀Ꮫ㸦㙊⏣ G㸧2013 ᖺ
Matsui, A., Kamada, Y., and Matsuura, A. (2013). The role of autophagy in genome stability throughsuppression of abnormal mitosis under starvation. PLOS Genetics 9, e1003245.
㸦3࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧 
2011 ᖺ
Yoshida, S., Imoto, J., Minato, T., Oouchi, R., Kamada, Y., Tomita, M., Soga, T., and Yoshimoto, H.
(2011) A novel mechanism regulates H2S and SO2 production in Saccharomyces cerevisiae. Yeast 28,
109-121.
ከᵝᛶ⏕≀Ꮫ㸦኱㔝 G㸧ከᵝᛶ⏕≀Ꮫ㸦ᫍ㔝㹅㸧
2012 ᖺ
Park, K.I., and Hoshino, A. (2012). A WD40-repeat protein controls proanthocyanidin and phytomelaninpigmentation in the seed coats of the Japanese morning glory. J. Plant Physiol. 169, 523-528.
Tong, L., Fukuoka, H., Otaka, A., Hoshino, A., Iida, S., Nitasaka, E., Watanabe, N., and Kumoyama, T.
(2012). Development of EST-SRR markers of Ipomoea nil. Breed. Sci. 62, 99-104.
2011 ᖺ
Higuchi, Y., Sage-Ono, K., Sasaki, R., Ohtsuki, N., Hoshino, A., Iida, S., Kamada H., and Ono, M.
(2011) Constitutive expression of the GIGANTEA ortholog affects circadian rhythms and suppresses
one-shot induction of flowering in Pharbitis nil, a typical short-day plant. Plant Cell Physiol. 52,
638-650.
Ohno, S., Hosokawa, M., Hoshino, A., Kitamura, Y., Morita, Y., Park, K. I., Nakashima, A., Deguchi, A.,
Tatsuzawa, F., Doi, M., Iida, S., and Yazawa, S. (2011) A bHLH transcription factor, DvIVS, is involved
in regulation of anthocyanin synthesis in dahlia (Dahlia variabilis). J. Exp. Bot. 62, 5105-5116.
Ohno, S., Hosokawa, M., Kojima, M., Kitamura, Y., Hoshino, A., Tatsuzawa, F., Doi M., and Yazawa, S.
(2011) Simultaneous post-transcriptional gene silencing of two different chalcone synthase genes
resulting in pure white flowers in the octoploid dahlia. Planta 234, 945-958.
Saito, N., Tatsuzawa, F., Hoshino, A., Abe, Y., Ichimura, M., Yokoi, M., Toki, K., Morita, Y., Iida, S.,
and Honda T. (2011) The anthocyanin pigmentation controlled by the speckled and c-1 mutations of theJapanese morning glory. J. Japan. Soc. Hort. Sci. 80, 452-460.

− 146 −

ከᵝᛶ⏕≀Ꮫ㸦ᰢ᰿ G㸧2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Hayashi-Tsugane, M., Takahara, H., Ahmed, N., Himi, E., Takagi, K., Iida, S., Tsugane, K., andMaekawa, M. A mutable albino allele in rice reveals that formation of thylakoid membranes requires
SNOW-WHITE LEAF1 gene. Plant Cell Physiol. 2013 Oct. 21.
2012 ᖺ
Eun, C.-H., Takagi, K., Park, K.I., Maekawa, M, Iida, S., and Tsugane, K. (2012). Activation andepigenetic regulation of DNA transposon nDart1 in rice. Plant Cell Physiol. 53, 857-868.
2011 ᖺ
Hayashi-Tsugane, M., Maekawa, M., Kobayashi H., Iida, S. and Tsugane, K. (2011) A ricemutant displaying a heterochronically elongated internode carries a 100 kb deletion. J. Genet. Genomics,
38, 123-128
Hayashi-Tsugane, M., Maekawa, M., Qian, Q., Kobayashi H., Iida, S. and Tsugane, K. (2011)
Examination of transpositional activity of nDart1 at different stages of rice development. Genes Genet.
Syst. 86, 215-219
ከᵝᛶ⏕≀Ꮫ㸦ᒣཱྀ G㸧2011 ᖺ
Ikeuchi, M., Yamaguchi, T., Kazama, T., Ito, T., Horiguchi, G., and Tsukaya, H. (2011).
ROTUNDIFOLIA4 regulates cell proliferation along the body axis in Arabidopsis shoot. Plant Cell
Physiol. 52, 59–69.
ከᵝᛶ⏕≀Ꮫ㸦ᐃሯ G㸧ከᵝᛶ⏕≀Ꮫ㸦Ώ㑔 ⪃ G㸧2011 ᖺ
Okamoto, H., Watanabe, T., and Horiuchi, T. (2011). Double rolling circle replication (DRCR) is
recombinogenic. Genes Cell 16, 503-513.
Watanabe, T., Tanabe, H., and Horiuchi, T. (2011). Gene amplification system based on double
rolling-circle replication as a model for oncogene-type amplification. Nucleic Acids Res. 39), e106.
ከᵝᛶ⏕≀Ꮫ㸦ᮌ᳃ G㸧
2013 ᖺ
Kimori, Y. (2013). Morphological image processing for quantitative shape analysis of biomedical
structures: effective contrast enhancement. J. Synchrotron Rad. 20, 848-853.
Kimori, Y., Baba, N., and Katayama, E. (2013). Novel configuration of a myosin II transient intermediate
analogue revealed by quick-freeze deep-etch replica electron microscopy. Biochemical J. 450, 23-35.
ศᏊ⎔ቃ⏕≀Ꮫ㸦஭ཱྀ◊㸧
2013 ᖺ
Brockmeier, E.K., Ogino, Y., Iguchi, T., Barber, D.S., and Denslow, N.D. (2013). Effects of17ȕ-trenbolone on Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) and anal fin
growth and gene expression patterns. Aquat. Toxicol. 128-129C, 163-170.
Hirakawa, I., Miyagawa, S., Mitsui, N., Miyahara, M., Onishi, Y., Kagami, Y., Kusano, T., Takeuchi,T., Ohta, Y., and Iguchi, T. (2013). Developmental disorders and altered gene expression in the tropicalclawed frog (Silurana tropicalis) exposed to 17Į-ethinylestradiol. J. Appl. Toxicol. 33, 1001-1010.
Hiruta, C., Toyota, K., Miyakawa, H., Ogino, Y., Miyagawa, S., Tatarazako, N., Shaw, J.R., and Iguchi,− 147 −

T. (2013). Development of a microinjection system for RNA interference in the water flea Daphnia
pulex. BMC Biotechnol. 13, 96.
Kakuta, H., Matsushita, A., Arikawa, K., Iguchi, T., and Sato, T. (2013). Cholesterol homeostasis in
the ovaries of neonatally diethylstilbestrol-treated mice. Exp. Clin. Endocr. Diabetes, 121, 94-101.
Katoh, T., Hayashi, S., Iguchi, T., and Sato, T. (2013). Epithelial-stromal interactions in the mousevagina exposed neonatally to diethylstilbestrol. In Vivo, 27, 333-337.
Katsu, Y., Lange, A., Miyagawa, S., Urushitani, H., Tatarazako, N., Kawashima, Y., Tyler, C.R., andIguchi, T. (2013). Cloning, expression and functional characterization of carp, Cyprinus carpio
estrogen receptors and their differential activations by estrogens. J. Appl. Toxicol., 33, 41-49.
Miyakawa, H., Toyota, K., Hirakawa, I., Ogino, Y., Miyagawa, S., Oda, S., Tatarazako, N., Miura, T.,
Colbourne, J.K., and Iguchi, T. (2013). A mutation in the Methoprene tolerant alters juvenile hormone
response in insects and crustaceans. Nature Commun. 4, 1856.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Oka, T., Mitsui-Watanabe, N., Tatarazako, N., Onishi, Y., Katsu, Y., Miyagawa, S., Ogino, Y., Yatsu,
R., Kohno, S., Takase, M., Kawashima, Y., Aoki, Y., Guillette, L.J.Jr., and Iguchi, T. (2013).
Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid
hormone receptors. J. Appl. Toxicol. 33, 991-1000.
Jeong, S.W., Lee, S.M., Yum, S.S., Iguchi, T., and Seo, Y.R. (2013). Genomic expression responses
toward bisphenol-A toxicity in Daphnia magna in terms of reproductive activity. Mol. Cell. Toxicol. 9,
149-158.
Toyota, K., Kato, Y., Sato, M., Sugiura, N., Miyagawa, S., Miyakawa, H., Watanabe, H., Oda, S.,
Ogino, Y., Hiruta, C., Mizutani, T., Tatarazako, N., Paland, S., Jackson, C., Colbourne, J.K., andIguchi, T. (2013). Molecular cloning of doublesex genes of four cladocera (water flea) species. BMC
Genomics 14, 239.
Urushitani, H., Katsu, Y., Ohta, Y., Shiraishi, H., Iguchi, T., and Horiguchi, T. (2013). Cloning andcharacterization of the retinoic acid receptor-like protein in the rock shell, Thais clavigera. Aquat.
Toxicol. 142-143C: 403-413.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧Nakamura, A., Takanobu, H., Tamura, I., Yamamuro, M., Iguchi, T., and Tatarazako, N. Verification of
responses of Japanese medaka (Oryzias latipes) to antiandrogens, vinclozolin and flutamide, inshort-term assays. J. Appl. Toxicol. 2013 Sep. 24.
Ogino, Y., Hirakawa, I., Inohaya, K., Sumiya, E., Miyagawa, S., Tatarazako, N., Denslow, M., Yamada,G., and Iguchi, T. Bmp7 and Lef1 are the downstream effectors of androgen signaling in
androgen-induced sex characteristics development in medaka. Endocrinology 2013 Nov. 18.
㸦3࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧Toyota, K., Kato, Y., Miyakawa, H., Yatsu, R., Mizutani, T., Ogino, Y., Miyagawa, S., Watanabe, H.,
Nishide, H., Uchiyama, I., Tatarazako, N., and Iguchi, T. Molecular impact of juvenile hormone agonists
on neonatal Daphnia magna. J. Appl. Toxicol. 2013 Sep. 5.
2012 ᖺ
Brockmeier, E.K., Ogino, Y., Iguchi, T., Barber, D.S., and Denslow, N.D. (2012). Effects of
17E-trenbolone on Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) and anal fin
growth and gene expression patterns. Aquat. Toxicol., 128-129C, 163-170.
Goto, Y., Kajiwara, M., Yanagisawa, Y., Hirose, H., Yoshimi, T., Uemura, M., Nakano, H., Takahashi,S., Shida, Y., Iguchi, T., Takahashi, Y. and Miura, T. (2012). Detection of vertebrate-type steroid
hormones and their converting activities in the neogastropod Thais clavigera (Kster, 1858). J. Molluscan
Studies, 78, 197-204.
Haraguchi, R., Matsumaru, D., Nakagata, N., Miyagawa, S., Suzuki, K., Kitazawa, S., and Yamada, G.
(2012). The hedgehog signal induced modulation of bone morphogenetic protein signaling: an essential
signaling relay for urinary tract morphogenesis. PLoS ONE 7, e42245.

− 148 −

Hirakawa, I., Miyagawa, S., Katsu, Y., Kagami, Y., Tatarazako, N., Kobayashi, T., Kusano, T., Mizutani,T., Ogino, Y., Takeuchi, T., Ohta, Y., and Iguchi, T. (2012). Gene expression profiles in the testis
associated with testis-ova in adult Japanese medaka (Oryzias latipes) exposed to 17D-ethinylestradiol.
Chemosphere 87, 668-674.
Kakuta, H., Tanaka, M., Chambon, P., Watanabe, H., Iguchi, T., and Sato, T. (2012). Involvement ofgonadotropins in the induction of hypertrophy-hyperplasia in the interstitial tissues of ovaries inneonatally diethylstilbestrol-treated mice. Reprod. Toxicol. 33, 35-44.
Lange, A., Katsu, Y., Miyagawa, S., Ogino, Y., Urushitani, H., Kobayashi, T., Hirai, T., Shears, J.A.,
Nagae, M., Yamamoto, J., Ohnishi, Y., Oka, T., Tatarazako, N., Ohta, Y., Tyler, C.R., and Iguchi, T.
(2012). Comparative responsiveness to natural and synthetic estrogens of fish species commonly used in
the laboratory and field monitoring. Aquat. Toxicol. 109, 250-258.
Maekawa, T., Sakuma, A., Taniuchi, S., Ogo, Y., Iguchi, T., Takeuchi, S., and Takahashi, S. (2012).
Transforming growth factor-Į mRNA expression and its possible roles in mouse endometrial stromalcells. Zool. Sci. 29, 377-383.
Myburgh, J.G., Huchzermeyer, F.W., Soley, J.T., Booyse, D.G., Groenewald, H.B., Bekker, L.C., Iguchi,T., and Guillette, L.J.Jr. (2012). Technique for the collection of clean urine from the Nile crocodile(Crocodylus niloticus). J. South African Vet. Assoc., 83, E1-6.
Nakajima, T., Iguchi, T., and Sato, T. (2012). Hedgehog signaling plays roles in epithelial cellproliferation in the neonatal mouse uterus and vagina. Cell Tiss. Res. 348, 239-247.
Nakamura, T., Miyagawa, S., Katsu, Y., Mizutani, T., Sato, T., Takeuchi, T., Iguchi, T., and Ohta, Y.
(2012). P21 and Notch signalings in the persistently altered vagina induced by neonatal diethylstilbestrol
exposure in mice. J. Vet. Med. Sci., 74, 1589–1595.
Nakamura, T., Miyagawa, S., Katsu, Y., Sato, T., Iguchi, T., and Ohta, Y. (2012). Sequential changes in
expression of Wnt- and Notch-related genes in the vagina and uterus of ovariectomized mice after
estrogen exposure. In Vivo 26, 899-906.
Nakamura, T., Miyagawa, S., Katsu, Y., Watanabe, H., Mizutani, T., Sato, T., Morohashi, K.-I., Takeuchi,T., Iguchi, T., and Ohta, Y. (2012). WNT family genes and their modulation in the ovary-independentand persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol
exposure in mice. Toxicology 296, 13-19.
Oka, K., Kohno, S., Uruchitani, H., Guillette, L.J.Jr., Ohta, Y., Iguchi, T., and Katsu, Y. (2012).
Molecular cloning and characterization of the corticoid receptors from the American alligator. Mol. Cell.
Endocrinol. 365, 153-161.
St. John, J.A., Braun, E.L., Isberg, S.R., Miles, L.G., Chong, A.Y., Gongora, J., Dalzell, P., Moran, C.,
Bed'hom, B., Abzhanov, A., Burgess, S.C., Cooksey, A.M., Castoe, T.A., Crawford, N.G., Densmore,
L.D., Drew, J.C., Edwards, S.V., Faircloth, B.C., Fujita, M.K., Greenwold, M.J., Hoffmann, F.G.,
Howard, J.M., Iguchi, T., Janes, D.E., Khan, S.Y., Kohno, S., de Koning, A.J., Lance, S.L., McCarthy,
F.M., McCormack, J.E., Merchant, M.E., Peterson, D.G., Pollock, D.D., Pourmand, N., Raney, B.J.,
Roessler, K.A., Sanford, J.R., Sawyer, R.H., Schmidt, C.J., Triplett, E.W., Tuberville, T.D.,
Venegas-Anaya, M., Howard, J.T., Jarvis, E.D., Guillette, L.J.Jr., Glenn, T.C., Green, R.E., and Ray, D.A.
(2012). Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes.
Genome Biol. 13, 415.
Takase, M., Shinto, H., Takao, Y., and Iguchi, T. (2012). Accumulation and pharmacokinetics of
estrogenic chemicals in the pre- and post-hatch embryos of the frog Rana rugosa. In Vivo 26, 913-920.
Taylor, J.A., Richter, C.A., Suzuki, A., Watanabe, H., Iguchi, T., Coser, K.R., Shioda, T., and vom Saal,
F.S. (2012). Dose-related estrogen effects on gene expression in fetal mouse prostate mesenchymal cells.
PLoS ONE 7, e48311.
2011 ᖺ
Bermudez, D.S., Skotko, J.P., Ohta, Y., Boggs, A.S.P., Iguchi, T., and Guillette, L.J.Jr. (2011). Sex
steroid and thyroid hormone receptor expressions in the thyroid of the American alligator (Alligator− 149 −

mississippiensis) during different life stages. J. Morphol. 272, 698-703.
Chakraborty, T., Katsu, Y., Zhou, L.Y., Miyagawa, S., Nagahama, Y., and Iguchi, T. (2011). Estrogen
receptors in medaka (Oryzias latipes) and estrogenic environmental contaminants: an in vitro-in vivo
correlation. J. Steroid Biochem. Mol. Biol. 123, 115-121.
Chakraborty, T., Shibata, Y., Zhou, L.Y., Katsu, Y., Iguchi, T., and Nagahama, Y. (2011). Differential
expression of three estrogen receptor subtype mRNAs in gonads and liver from embryos to adults of the
medaka, Oryzias latipes. Mol. Cell. Endocrinol. 333, 47-54.
Kato, Y., Kobayashi, K., Watanabe, H., and Iguchi, T. (2011). Environmental sex determination in the
branchiopod crustacean Daphnia magna: Deep conservation of a Doublesex gene in the sex-determining
pathway. PLoS Genetics 7, e1001345. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

Kato, Y., Shiga, Y., Kobayashi, K., Tokishita, S., Yamagata, H., Iguchi, T., and Watanabe, H. (2011).
Development of an RNA interference method in the cladoceran crustacean Daphnia magna. Devel.
Genes Evol. 220, 337-345.
Lange, A., Paull, G.C., Hamilton, P.B., Iguchi, T., and Tyler, C.R. (2011). Implications of persistent
exposure to treated wastewater effluent for breeding in wild roach (Rutilus rutilus) populations. Environ.
Sci. Technol. 45, 1673-1679.
Matsumura, D., Haraguchi, R., Miyagawa, S., Motoyama, J., Nakagata, N., Meijlink, F., and Yamada G.
(2011). Genetic analysis of hedgehog signaling in ventral body wall development and the onset ofomphalocele formation. PLoS ONE 20, e16260.
Miyagawa, S., Matsumaru, D., Murashima, A., Omori, A., Satoh, Y., Haraguchi, R., Motoyama, J.,
Iguchi, T., Nakagata, N., Hui, C.C., and Yamada, G. (2011). The role of sonic hedgehog-Gli2 pathway inthe masculinization of external genitalia. Endocrinology 152, 2894-2903.
Moore, B.C., Milnes, M.R., Kohno, S., Katsu, Y., Iguchi, T., Woodruff, T.K., and Guillette, L.J.Jr.
(2011). Altered gonadal expression of TGF-ȕ VXSHUIDPLO\ VLJQDOLQJ IDFWRUV LQ HQYLURQPHQWDO
contaminant-exposed juvenile alligators. J. Steroid Biochem. Mol. Biol. 127, 58-63.
Murashima, A., Miyagawa, S., Ogino, Y., Nishida-Fukuda, H., Araki, K., Matsumoto, T., Kaneko, T.,
Yoshinaga, K., Yamamura, K.I., Kurita, T., Kato, S., Moon, A.M., and Yamada, G. (2011). Essential
roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation.
Endocrinology 152, 1640-1651.
Nakajima, T., Hayashi, S., Iguchi, T., and Sato, T. (2011). The role of fibroblast growth factors on the
differentiation of vaginal epithelium of neonatal mice. Differentiation 82, 28-37.
Nakajima, T., Iguchi, T., and Sato, T. (2011). Involvement of activin signaling in abnormalities of themouse vagina exposed neonatally to diethylstilbestrol. Cell Tiss. Res. 344, 527-538.
Southam, A.D., Lange, A., Hines, A., Hill, E.M., Katsu, Y., Iguchi, T., Tyler, C.R., and Viant, M.R.
(2011). Metabolomics reveals target and off-target toxicities of a model organophosphate pesticide toroach (Rutilus rutilus): Implications for biomonitoring. Environ. Sci. Technol. 45, 3759-3767.
Urushitani, H., Katsu, Y., Miyagawa, S., Kohno, S., Ohta, Y., Guillette, L.J.Jr., and Iguchi, T. (2011).
Molecular cloning of anti-Müllerian hormone from the American alligator, Alligator mississippiensis.
Mol. Cell. Endocrinol. 333, 190-199.
Urushitani, H., Katsu, Y., Ohta, Y., Shiraishi, H., Iguchi, T., and Horiguchi, T. (2011). Cloning a nd
characterization of retinoid X receptor (RXR) isoforms in the rock shell, Thais clavigera. Aquat.
Toxicol. 103, 101-111.
⎔ቃග⏕≀Ꮫ㸦ⓙᕝ◊㸧2013 ᖺ
Allorent, G., Tokutsu, R., Roach, T., Peers, G., Cardol, P., Girard-Bascou, J., Seigneurin-Berny, D.,− 150 −

Petroutsos, D., Kuntz, M., Breyton, C., Franck, F., Wollman, F.-A., Niyogi, K.K., Kreiger-Liszkay, A.,
Minagawa, J., and Finazzi, G. (2013). A dual strategy to cope with high light in Chlamydomonas
reinhardtii. Plant Cell 25, 545-557. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Tokutsu, R., and Minagawa, J. (2013). Energy-dissipative supercomplex of photosystem II associatedwith LHCSR3 in Chlamydomonas reinhardtii. Proc. Natl. Acad. Sci. USA 110, 10016-10021.
㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧

2012 ᖺ
Tokutsu, R., Kato, N., Bui, K. H., Ishikawa, T., and Minagawa, J. (2012). Revisiting the supramolecularorganization of photosystem II in Chlamydomonas reinhardtii. J. Biol. Chem. 287, 31574-31581.
Ꮨ⠇⏕≀Ꮫ㸦ྜྷᮧ◊㸧ᐈဨ
2013 ᖺ
Nakane, Y., Ikegami, K., Iigo, M., Ono, H., Takeda, K., Takahashi, D., Uesaka, M., Kimijima, M.,
Hashimoto, R., Arai, N., Suga, T., Kosuge, K., Abe, T., Maeda, R., Senga, T., Amiya, N., Azuma, T.,
Amano, M., Abe, H., Yamamoto, N., and Yoshimura, T. (2013). The saccus vasculosus of fish is asensor of seasonal changes in day length. Nature Commun. 4, 2108.
ࢤࣀ࣒᝟ሗ㸦ෆᒣ㹅㸧
2013 ᖺ
Uchiyama, I., Mihara, M., Nishide, H., and Chiba, H. (2013). MBGD update 2013: the microbial
genome database for exploring the diversity of microbial world. Nucleic Acids Res. 41, D631-D635.
Yahara, K., Furuta, Y., Oshima, K., Yoshida, T., Azuma, T., Hattori, M., Uchiyama, I., and Kobayashi,
I. (2013). Chromosome painting in silico in a bacterial species reveals fine population structure. Mol.
Biol. Evol., 30, 1454-1464.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧
Toyota, K., Kato, Y., Miyakawa, H., Yatsu, R., Mizutani, T., Ogino, Y., Miyagawa, S., Watanabe, H.,
Nishide, H., Uchiyama, I., Tatarazako, N., and Iguchi, T. Molecular impact of juvenile hormone agonists
on neonatal Daphnia magna. J. Appl. Toxicol. 2013 Sep. 5.
2012 ᖺ
Takami, H., Noguchi, H., Takaki, Y., Uchiyama, I., ,Toyoda, A., Nishi, S., Chee, G-J., Arai, W., Nunoura,T., Itoh, T., Hattori, M., and Takai, K. (2012). A deeply branching thermophilic bacterium with anancient acetyl-CoA pathway dominates a subsurface ecosystem. PLoS ONE 7, e30559.
Yahara, K., Kawai, M., Furuta, Y., Takahashi, N., Handa, N., Tsuru, T., Oshima, K., Yoshida, M.,
Azuma, T., Hattori, M., Uchiyama, I., and Kobayashi, I. (2012). Genome-wide survey of mutual
homologous recombination in highly sexual bacterial species, Genome Biol. Evol. 4, 628-640.
Uchiyama, I., Mihara, M., Nishide, H., and Chiba, H. MBGD update 2013: the microbial genome
database for exploring the diversity of microbial world. Nucleic Acids Res. 2012 Oct 30.
2011 ᖺ
Furuta, Y., Kawai, M., Uchiyama, I., and Kobayashi, I. (2011). Domain movement within a gene: a novel
evolutionary mechanism for protein diversification. PLoS ONE, 6, e18819.
Furuta, Y., Kawai, M., Yahara, K., Takahashi, N., Handa, N., Tsuru, T., Oshima, K., Yoshida, M.,
Azuma, T., Hattori, M., Uchiyama, I., and Kobayashi, I. (2011). Birth and death of genes linked tochromosomal inversion, Proc. Natl. Acad. Sci. USA, 108, 1501-1506.
Kawai, M., Furuta, Y., Yahara, K., Tsuru, T., Oshima, K., Handa, N., Takahashi, N., Yoshida, M.,
Azuma, T., Hattori, M., Uchiyama, I., and Kobayashi, I. (2011). Evolution in an oncogenic bacterial
species with extreme genome plasticity: Helicobacter pylori East Asian genomes. BMC Microbiology,
11, 104.

− 151 −Yamamoto, K., Tanaka, H., Nishitani, Y., Nishiumi, S., Miki, I., Takenaka, M., Nobutani, K., Mimura, T.,
Ben Suleiman, Y., Mizuno, S., Kawai, M., Uchiyama, I., Yoshida, M., and Azuma, T. (2011).
Helicobacter suis KB1 derived from pig gastric lymphoid follicles induces the formation of gastriclymphoid follicles in mice through the activation of B cells and CD4 positive cells. Mocrobes Infect, 13,
697-708.
᫬✵㛫ไᚚ㸦㔝୰㹅㸧
2013 ᖺ
Ichikawa, T., Nakazato, K., Keller, P.J., Kajiura-Kobayashi, H., Stelzer, E.H., Mochizuki, A., andNonaka, S. (2013). Live imaging of whole mouse embryos during gastrulation: migration analyses of
epiblast and mesodermal cells. PLoS ONE 8, e64506. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Murata, T., Sano, T., Sasabe, M., Nonaka, S., Higashiyama, T., Hasezawa, S., Machida, Y., andHasebe, M. (2013). Mechanism of microtubule array expansion in the cytokinetic phragmoplast.
Nature Commun. 4, 1967. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Takao, D., Nemoto, T., Abe, T., Kiyonari, H., Kajiura-Kobayashi, H., Shiratori, H., and Nonaka, S.
(2013). Asymmetric distribution of dynamic calcium signals in the node of mouse embryo duringleft-right axis formation. Develop. Biol. 376, 23-30. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
2012 ᖺMorita, H., Kajiura-Kobayashi, H., Takagi, C., Yamamoto, T.S., Nonaka, S., and Ueno, N. (2012). Cell
movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Development 139, 1417-1426.㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫࢆᥖ㍕㸧
Oshima, Y., Sato, H., Kajiura-Kobayashi, H., Kimura, T., Naruse, K., and Nonaka, S. (2012). Lightsheet-excited spontaneous Raman imaging of a living fish by optical sectioning in a wide field Raman
microscope. Optics Express 20, 16195-16204. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Takao, D., Taniguchi, A., Takeda, T., Sonobe, S., and Nonaka, S. (2012). High-speed imaging of
amoeboid movements using light-sheet microscopy. PLoS ONE 7, e50846.
Yoshiba, S., Shiratori, H., Kuo, I.Y., Kawasumi, A., Shinohara, K., Nonaka, S., Asai, Y., Sasaki, G., Belo,
J.A., Sasaki, H., et al. (2012). Cilia at the node of mouse embryos sense fluid flow for left-rightdetermination via Pkd2. Science 338, 226-231.

2011 ᖺ
Kishimoto., N., Alfaro-Cervello, C., Shimizu, K., Asakawa, K., Urasaki, A., Nonaka, S., Kawakami, K.,
Garcia-Verdugo, JM., and Sawamoto, K. (2011). Migration of neuronal precursors from the telencephalicventricular zone into the olfactory bulb in adult zebrafish. Journal of Comparative Neurology 519,
3549-3565.
⏕≀ᶵ⬟᝟ሗศᯒ㸦㔜ಙ㹅㸧
2013 ᖺ
Chang, C.-C., Hsiao, Y.-M., Huang, T.Y., Cook, C.E., Shigenobu, S., and Chang, T.-H. (2013).
Noncanonical expression of caudal during early embryogenesis in the pea aphid Acyrthosiphon pisum:
maternal cad-driven posterior development is not conserved. Insect Mol. Biol. 22, 442–455.
Hayashi, Y., Shigenobu, S., Watanabe, D., Toga, K., Saiki, R., Shimada, K., Bourguignon, T., Lo, N.,
Hojo, M., Maekawa, K., et al. (2013). Construction and characterization of normalized cDNA libraries
by 454 pyrosequencing and estimation of DNA methylation levels in three distantly related termite
species. PLoS ONE 8, e76678.
Shibata, T.F., Maeda, T., Nikoh, N., Yamaguchi, K., Oshima, K., Hattori, M., Nishiyama, T., Hasebe,M., Fukatsu, T., Kikuchi, Y., et al. (2013). Complete genome sequence of Burkholderia sp. strain
RPE64, bacterial symbiont of the bean bug Riptortus pedestris. Genome Announc. 1,
e00441–13–e00441–13.

− 152 −

Shigenobu, S., and Stern, D.L. (2013). Aphids evolved novel secreted proteins for symbiosis withbacterial endosymbiont. Proc. Biol. Sci. 280, 20121952. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Suzuki, M.M., Yoshinari, A., Obara, M., Takuno, S., Shigenobu, S., Sasakura, Y., Kerr, A.R., Webb, S.,
Bird, A., and Nakayama, A. (2013). Identical sets of methylated and nonmethylated genes in Ciona
intestinalis sperm and muscle cells. Epigenetics Chromatin 6, 38.
2012 ᖺ
Gallot, A., Shigenobu, S., Hashiyama, T., Jaubert-Possamai, S. and Tagu, D. (2012). Sexual and asexualoogenesis require the expression of unique and shared sets of genes in the insect Acyrthosiphon pisum.
BMC Genomics 13, 76
Hojo, M., Maekawa, K., Saitoh, S., Shigenobu, S., Miura, T., Hayashi, Y., Tokuda, G., and Maekawa, H.
(2012). Exploration and characterization of genes involved in the synthesis of diterpene defence secretionin nasute termite soldiers. Insect Mol. Biol. 21, 545-557.
2011 ᖺ
Price, D., Duncan, R., Shigenobu, S., and Wilson, A. (2011). Genome expansion and differential
expression of amino acid transporters at the aphid/Buchnera symbiotic interface. Mol. Biol. Evol. 28,
3113–3126.
ගᏛゎᯒ㸦ட஭㹅㸧2013 ᖺ
Okuyama, T., Isoe, Y., Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y.,
Shimizu, A., Kubo, T., and Takeuchi H. (2013). Controlled Cre/loxP site-specific recombination in thedeveloping brain in medaka fish, Oryzias latipes. PLoS ONE.8, e66597.
Ikehata, H., Higashi, S., Nakamura, S., Daigaku, Y., Furusawa, Y., Kamei, Y., Watanabe, M.,
Yamamoto, K., Hieda, K., Munakata, N., and Ono, T. (2013). Action spectrum analysis of UVR
genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads
to skin. J. Invest. Dermatol. 133, 1850-1856.
Shikata, T., Matsunaga, S., Iseki, M., Nishide, H., Higashi, S-I., Kamei, Y., Yamaguchi,M., Jenkinson, I.R., and Watanabe, M. (2013). Blue light regulates the rhythm of diurnal verticalmigration in the raphidophyte red-tide alga Chattonella antiqua. J. Plankton Res. 35, 542-552.
Kimura, E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., and Hitomi, J. (2013). Application of infraredlaser to the zebrafish vascular system: gene induction, tracing, and ablation of single endothelal
cells. Arterioscler. Thromb. Vasc. Biol. 33, 1264-1270. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨ࢆᥖ㍕㸧
Shimada, A., Kawanishi, T., Kaneko, T., Yoshihara, H., Yano, T., Inohaya, K., Kinoshita, M., Kamei,Y., Tamura, K., and Takeda, H. (2013). Trunk exoskeleton in teleosts is mesodermal in origin. Nature
Commun. 4, 1639. 㸦3 ࡟ࣉࣞࢫ࣮ࣜࣜࢫࢆᥖ㍕㸧
Kobayashi, K., Kamei, Y., Kinoshita, M., Czerny, T., and Tanaka, M. (2013). A heat-inducible
Cre/LoxP gene induction system in medaka. Genesis. 51, 59-67.
Ishikawa, T., Okada, T., Ishikawa-Fujiwara, T., Todo, T., Kamei, Y., Shigenobu, S., Tanaka, M., Saito,
T.L., Yoshimura, J., Morishita, S., Toyoda, A., Sakaki, Y., Taniguchi, Y., Takeda, S., and Mori, K.
(2013). ATF6a/b-dediated adjustment of ER chaperone levels is essential for development of thenotochord in medaka fish. Mol. Biol. Cell 24, 1387-1395.
2012 ᖺ
Ansai, S., Ochiai, H., Kanie, Y., Kamei, Y., Gou, Y., Kitano, T., Yamamoto, T., and Kinoshita, M.
(2012). Targeted disruption of exogenous EGFP gene in medaka using zinc-finger nucleases. Dev.
Growth Differ. 54, 546-556.
Kitano, T., Hayashi, Y., Shiraishi, E., and Kamei, Y. (2012). Estrogen rescues masculinization ofgenetically female medaka by exposure to cortisol or high temperature. Mol. Reprod. Dev. 79, 719-726.

− 153 −

Masuyama, H., Yamada, M., Kamei, Y., Fujiwara-Ishikawa, T., Todo, T., Nagahama, Y., and Matsuda,
M. (2012). Dmrt1 mutation causes a male-to-female sex reversal after the sex determination by Dmy in
the medaka. Chromosome Res. 20, 163-176.
Yasuda, T., Oda, S., Li, Z., Kimori, Y., Kamei, Y., Ishikawa, T., Todo, T., and Mitani, H. (2012).
Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in thetestis of p53-deficient medaka (Oryzias latipes). Cell Death Dis. 3, e3952011 ᖺ
Shikata, T., Iseki, M., Matsunaga, S., Higashi, S., Kamei, Y., and Watanabe, M. (2011). Blue and red
light-induced germination of resting spores in the red-tide diatom Leptocylindrus danicus. Photochem.
Photobiol. 87, 590-597.
ගᏛゎᯒᐊඹྠ฼⏝㸦DSLM ࢆྵࡴ㸧2013 ᖺ
Allorent, G., Tokutsu, R., Roach, T., Peers, G., Cardol, P., Girard-Bascou, J., Seigneurin-Berny, D.,
Petroutsos, D., Kuntz, M., Breyton, C., Franck, F., Wollman, F.-A., Niyogi, K.K., Krieger-Liszkay, A.,
Minagawa, J. andFinazzi, G. (2013). A dual strategy to cope with high light in Chlamydomonas
reinhardtii. Plant Cell. 25, 545-557.
Ikehata, H., Higashi, S., Nakamura, S., Daigaku, Y., Furusawa, Y., Kamei, Y., Watanabe, M.,
Yamamoto, K., Hieda, K., Munakata, N., and Ono, T. (2013). Action spectrum analysis of UVR
genotoxicity for skin: the border wavelengths between UVA and UVB can bring serious mutation loads
to skin.J. Invest. Dermatol.133, 1850-1856.
Shikata, T., Matsunaga, S., Iseki, M., Nishide, H., Higashi, S., Kamei, Y., Yamaguchi, M., Jenkinson,
I.R., and Watanabe, M. (2013). Blue light regulates the rhythm of diurnal vertical migration in theraphidophyte red-tide algaChattonella antiqua. J. Plankton Res.35, 542-552.
Okuyama, T., Isoe, Y., Hoki, M., Suehiro, Y., Yamagishi, G., Naruse, K., Kinoshita, M., Kamei, Y.,
Shimizu, A., Kubo, T., and Takeuchi, H. (2013). Controlled cre/loxP site-specific recombination in thedeveloping brain in medaka fish, Oryzias latipes. PLoS ONE. 8, e66597.
Murata, T., Sano, T., Sasabe, M., Nonaka, S., Higashiyama, T., Hasezawa, S., Machida, Y., andHasebe, M. (2013). Mechanism of microtubule array expansion in the cytokinetic phragmoplast. Nat.
Commun.4, 1967.
Sato-Numata, K., Numata, T., Okada, T., and Okada, Y. (2013). Acid-sensitive outwardly rectifying(ASOR) anion channels in human epithelial cells are highly sensitive to temperature and independentof CIC-3. Pflugers Arch-Eur. J. Physiol. 465, 1535-1543.
Suzaki, T., Ito, M., and Kawaguchi, M. (2013). Induction of localized auxin response during
spontaneous nodule development in Lotus japonicus. Plant Signal Behav. 8, e23359.
Takahara, M., Magori, S., Soyano, T., Okamoto, S., Yoshida, C., Yano, K., Sato, S., Tabata, S.,
Yamaguchi, K., Shigenobu, S., Takeda, N., Suzaki, T.,and Kawaguchi, M. (2013). Too much love, anovel Kelch repeat-containing F-box protein, functions in the long-distance regulation of thelegume-Rhizobium symbiosis. Plant Cell Physiol.54, 433-447.
Yamagata, Y., Kaneko, K., Kase, D., Ishihara, H., Nairn, A.C., Obata, K., and Imoto, K. (2013).
Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor- induced seizure activity
in cortical slices. Brain Res. 24, 1-10.
Kimura, E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., and Hitomi, J. (2013). Application of infraredlaser to the zebrafish vascular system: gene induction, tracing, and ablation of single endothelal
cells.Arterioscler. Thromb. Vasc. Biol. 33, 1264-1270.
Hira, R., Ohkubo, F., Tanaka, Y.R., Masamizu, Y., Augustine, J.G., Kasai, H., and Matsuzaki, M.
(2013). In vivo optogenetic tracing of functional corticocortical connections between motor forelimb− 154 −

areas.Front. Neural Circuits.7, 55.
Shimada, A., Kawanishi, T., Kaneko, T., Yoshihara, H., Yano, T., Inohaya, K., Kinoshita, M., Kamei,Y., Tamura, K., and Takeda, H. (2013). Trunk exoskeleton in teleosts is mesodermal in origin. Nat.
Commun.4, 1639.
Kobayashi, K., Kamei, Y., Kinoshita, M., Czerny, T., and Tanaka, M. (2013). A heat-inducible
Cre/LoxP gene induction system in medaka. Genesis. 51, 59-67.
Moritoh, S., Komatsu, Y., Yamamori, T., and Koizumi, A. (2013). Diversity of retinal ganglion cells
identified by transient GFP transfection in organotypic tissue culture of adult marmoset monkey retina.
PLoS ONE.8,e54667.
Suzaki, T., Kim, C.S., Takeda, N., Szczyglowski, K., and Kawaguchi, M. (2013). TRICOT encodes an
AMP1-related carboxypeptidase that regulates root nodule development and shoot apical meristem
maintenance in Lotus japonicus. Development 140, 353-361.
2012 ᖺMoritoh, S., Eun, C-H., Ono, A., Asao, H., Okano, Y., Yamaguchi, K., Shimatani, Z., Koizumi, A., andTerada, R. (2012). Targeted disruption of an orthologue of DOMAINS REARRANGED METHYLASE 2,OsDRM2, impairs the growth of rice plants by abnormal DNA methylation. Plant J. 71, 85-98.
Satoh, C., Kimura, Y., and Higashijima, S. (2012). Generation of multiple classes of V0 neurons inzebrafish spinal cord: Progenitor heterogeneity and temporal control of neuronal diversity. J. Neurosci.
32, 1771-1783.
Suzaki, T., Yano, K., Ito, M, Umehara, Y., Suganuma, N., and Kawaguchi, M. (2012). Positive andnegative regulation of cortical cell division during root nodule development in Lotus japonicus isaccompanied by auxin response. Development 139, 3997-4006.
Takeda, N., Maekawa, T., and Hayashi, M. (2012). Nuclear-localized and deregulated calcium- and
calmodulin-dependent protein kinase activates Rhizobial and Mycorrhizai responses in Lotus japonicus.
Plant Cell 24, 810-822.
Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka, M., Hioki, H.,
Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura, Y., and Yamamori, T. (2012). Visualization ofCortical Projection Neurons with Retrograde TET-Off Lentiviral Vector. PLoS ONE 7, e46157.
Kitano, T., Hayashi, Y., Shiraishi, E. and Kamei, Y. (2012) Estrogen rescues masculinization ofgenetically female medaka by exposure to cortisol or high temperature. Mol. Reprod. Dev. 79, 719-26.
Shimizu, A. and Shimizu, N. (2012) Dual promoter expression system with insulator ensures a stringent
tissue-specific regulation of two reporter genes in the transgenic fish. Transgenic Res. 22, 435-44.
Yasuda, T., Oda, S., Li, Z., Kimori, Y., Kamei, Y., Ishikawa, T., Todo, T. and Mitani, H. (2012)
Gamma-ray irradiation promotes premature meiosis of spontaneously differentiating testis-ova in thetestis of p53-deficient medaka (Oryzias latipes). Cell Death Dis. 3, e395.
Ansai, S., Ochiai, H., Kanie, Y., Kamei, Y., Gou, Y., Kitano, T., Yamamoto, T. and Kinoshita, M. (2012)
Targeted disruption of exogenous EGFP gene in medaka using zinc-finger nucleases.
Develop. Growth. Differ. 54. 546-556.
Takao, D., Taniguchi, A., Takeda, T., Sonobe, S., Nonaka, S. (2012) High-speed imaging of amoeboid
movements using light-sheet microscopy. PLoS One. 7, e50846.
Oshima, Y., Sato, H., Kajiura-Kobayashi, H., Kimura, T., Naruse, K., Nonaka, S. (2012) “Lightsheet-excited spontaneous Raman imaging of a living fish by optical sectioning in a wide field Raman
microscope” Optics Express 20, 16195-16204.
Morita, H., Kajiura-Kobayashi, H., Takagi, C., Yamamoto, T.S., Nonaka, S., Ueno, N. (2012) Cell
movements of the deep layer of non-neural ectoderm underlie complete neural tube closure in Xenopus.
Development, 139, 1417-1426.

− 155 −

2011 ᖺOsada, H., Yoshitake, Y., Ikeda, T., Ishigaki, Y., Takata, T., Tomosugi, N., Sasaki, H., and Yonekura,
H. (2011). Ultraviolet B-induced expression of amphiregulin and growth differentiation factor 15 inhuman lens epithelial cells. Mol. Vis. 17, 159-169.
Shikata, T., Iseki, M., Matsunaga, S., Higashi, S., Kamei, Y., and Watanabe, M. (2011). Blue and red
light-induced germination of resting spores in the red-tide diatom Leptocylindrus danicus. Photochem.
Photobiol. 87, 590-597.
Andrady, A.L., Hamid, H., and Torikai, A. (2011). Effects of solar UV and climate change on materials.
Photochem. Photobiol. Sci. 10, 292-300.
Karahara, I., Takaya, E., Fujibayashi, S., Inoue, H., Weller, J. L., Reid, J.B., and Sugai, M. (2011).
Development of the Casparian strip is delayed by blue light in pea stems. Planta 234, 1019-1030.
Hamasaka, G., Muto, T., and Uozumi, Y. (2011). Molecular-architecture-based administration of
catalysis in water: self-assembly of an amphiphilic palladium pincer complex. Angew. Chem. 50,
4876-4878.
Okubo, T., Kawamura, A., Takahashi, J., Yagi, H., Morishima, M., Matsuoka, R., and Takada, S.
(2011). Ripply3, a Tbx1 repressor, is required for development of the pharyngeal apparatus and its
derivatives in mice. Development 138, 339-348.
Moritoh, S., Sato, K., Okada, Y., and Koizumi, A. (2011). Endogenous arginine vasopressin–positive
retinal cells in arginine vasopressin–eGFP transgenic rats identified byimmunohistochemistry andreverse transcriptase– polymerase chain reaction. Mol.Vis. 17, 3254-3261.
Inada, H., Watanabe, M., Uchida, T., Ishibashi, H., Wake, H., Nemoto, T., Yanagawa, Y., Fukuda, A.,
and Nabekura, J. (2011). GABA regulate the multidirectional tangential migration of GABAergic
interneurons in living neonatal mice. Plos One 6, e277048.
Chisada, S., Okamoto, H., Taniguchi, Y., Kimori, Y., Toyoda, A., Sakaki, Y., Takeda, S. and Yoshiura,
Y. (2011) Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia andhypertrophy, which occur sequentially during post-hatch development. Dev Biol. 359, 82-94.
IBBP ࢭࣥࢱ࣮㸦⏣୰㹅㸧
2013 ᖺ
Matsumoto, T., Akihiro, T., Maki, S., Mochida, K., Kitagawa, M., Tanaka, D., Yamamoto, S., andNiino, T. (2013). Genetic stability assessment of wasabi plants regenerated from long-term
cryopreserved shoot tips using morphological, biochemical and molecular analysis. Cryo Letters 34,
128-136.
Niwa, N., Akimoto-Kato, A., Sakuma, M., Kuraku, S., and Hayashi, S. (2013). Homeogenetic
inductive mechanism of segmentation in polychaete tail regeneration. Dev. Biol. 381, 460-470.
2013 ᖺ㸦༳ๅ࡟ඛ❧ࡗ࡚㟁Ꮚฟ∧㸧Kondo, T., Sakuma, T., Wada, H., Akimoto-Kato, A., Yamamoto, T., Hayashi, S. TALEN-induced
gene knock out in Drosophila. Dev. Growth Differ. 2013 Oct. 31.
IBBP ࢭࣥࢱ࣮㸦ᮌᮧ㹅㸧
2013 ᖺ
Ohshima, A., Morimura, N., Matsumoto, C., Hiraga, A., Komine, R., Kimura, T., Naruse, K., andFukamachi, S. (2013). Effects of body-color mutations on vitality: an attempt to establish easy-to-breed
see-through medaka strains by outcrossing. G3 3, 1577-1585.


− 156 −

㸰㸧㸰㸮㸯㸱㸫㸰㸮㸯㸯ࣉࣞࢫ࣮ࣜࣜࢫ࡜᪂⪺ሗ㐨 ᖺ  ᭶  ᪥⮬ᕫ⣽⬊Ṛࢆಁࡍࢩࢫࢸ࣒ࡢ⋓ᚓࡀ᳜≀㝣ୖ໬ࡢ㘽ࢆᥱࡗ࡚࠸ࡓ㸟㹼ࢥࢣࡀỈࢆ㐠ࡪ⣽⬊ࡸయࢆᨭ࠼ࡿ⣽⬊ࢆసࡿ௙⤌ࡳࢆୡ⏺࡛ึࡵ࡚ゎ᫂㹼
Xu, B., Ohtani, M., Yamaguchi, M., Toyooka, K., Wakazaki, M., Sato, M., Kubo,
M., Nakano, Y., Sano, R., Hiwatashi, Y., Murata, T., Kurata, T., Yoneda, A.,
Kato, K., Hasebe, M., and Demura, T. (2014). Contribution of NAC
transcription factors to plant adaptation to land. Science 343, 1505-1508.
ዉⰋඛ➃⛉Ꮫᢏ⾡኱Ꮫ㝔኱Ꮫࣂ࢖࢜ࢧ࢖࢚ࣥࢫ◊✲⛉ࡢᚎἼ㸦;X%R㸧◊✲ဨࠊฟᮧᣅᩍᤵ࡜ࠊ⌮໬Ꮫ◊✲ᡤ⎔ቃ㈨※⛉Ꮫ◊✲ࢭࣥࢱ࣮ࡢ኱㇂⨾Ἃ㒔◊✲ဨࠊ㇏ᒸබᚨୖ⣭◊✲ဨࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㛗㇂㒊ගὈᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊࢥࢣ᳜≀ࡀࠊయෆ࡟Ỉࢆ㐠ࡪ㏻ࡾ㐨ࡢࠕ㏻Ỉ⣽⬊ࠖ࡜యࢆᨭ࠼ࡿࡓࡵࡢ
ࠕᨭᣢ⣽⬊ࠖ࡜࠸࠺㸰✀㢮ࡢ≉Ṧ࡞⣽⬊ࢆసࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡲࡓࠊࡇࡢ௙⤌ࡳࡢ୰࡛ࡣࠊ
⮬ᕫࡢ⣽⬊ࢆṚ࡞ࡏ࡚㸦⮬ᕫ⣽⬊Ṛ㸧ṧࡗࡓ⣽⬊ࡢᵓ㐀ࢆ฼⏝ࡍࡿࢩࢫࢸ࣒ࡀ㔜せ࡛࠶ࡿࡇ࡜ࢆࠊᐇ㦂ⓗ࡟ୡ⏺࡛ึࡵ࡚ド᫂ࡋࡲࡋࡓࠋཎጞⓗ࡞᳜≀࡛㐍໬ࡋࡓయෆࡢỈࢆຠ⋡ⓗ࡟㍺㏦ࡍࡿ௙⤌ࡳࡀࠊ᳜≀ࡢỈ୰࠿ࡽ㝣ୖ࡬ࡢ㐍ฟ࡜ࡑࡢᚋࡢ㝣ୖ࡛ࡢ⦾ᰤ࡟ᚲ㡲࡛࠶ࡗࡓ࡜࠸࠺௬ㄝࢆ⿬௜ࡅࡿࡶࡢ࡛ࡍࠋࡉࡽ
࡟ࠊᮏ◊✲࡟ࡼࡗ࡚ࠊᮌ㉁ࣂ࢖࣐࢜ࢫࢆ⏕ࡳฟࡍ⣽⬊࡛࠶ࡿ㐨⟶ࡸ⧄⥔⣽⬊ࡀసࡽࢀࡿ௙⤌ࡳࡀ඲㝣ୖ᳜≀࡟ඹ㏻ࡋ࡚࠸ࡿࡇ࡜ࡀド᫂ࡉࢀࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊᖹᡂ㸰㸴ᖺ㸱᭶㸰㸮᪥㸦ᮌ㸧௜ࡅࡢ⡿ᅜࡢ⛉Ꮫ㞧ㄅ 6FLHQFH 㟁Ꮚ∧㸦6FLHQFH([SUHVV㸧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸᪥หᕤᴗ᪂⪺ 㠃ࠊ᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ:HE࣐࢖ࢼࣅ
 ᖺ  ᭶  ᪥᪥⤒⏘ᴗ᪂⪺ 㠃− 157 −

 ᖺ  ᭶  ᪥ගྜᡂ཯ᛂㄪ⠇ࡢࡋࡃࡳࢫࢸ࣮ࢺ㑄⛣ࡢゎ᫂
Nagy, G., Ünnep, R., Zsiros, O., Tokutsu, R., Takizawa, K., Porcar, L., Moyet, L.,
Petroutsos, D., Garab, G., Finazzi, G., and Minagawa, J. (2014). Chloroplast
remodeling during state transitions in Chlamydomonas reinhardtii as revealed
by non-invasive techniques in vivo. Proc. Natl. Acad. Sci. USA 111, 5042-5047.
ᇶ♏⏕≀Ꮫ◊✲ᡤ⎔ቃග⏕≀Ꮫ◊✲㒊㛛㸦ⓙᕝ⣧ᩍᤵࠊᚓὠ㝯ኴ㑻ຓᩍ㸧ࠊࢫ࢖ࢫ࣭࣏࣮ࣝࢩ࢙࣮ࣛ◊✲ᡤࠊࣁ࣮ࣥ࢞ࣜ⛉Ꮫ࢔࢝ࢹ࣑࣮ࠊࣇࣛࣥࢫཎᏊຊ௦࢚᭰ࢿࣝࢠ࣮ᗇ࡞࡝ࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ⥳⸴ࡀගྜᡂ཯ᛂࢆㄪ⠇ࡍࡿࡋࡃࡳࠕࢫࢸ࣮ࢺ㑄⛣ࠖࡢᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ᳜≀ࡢගྜᡂࡣከࡃࡢࢫࢸࢵ
ࣉ࠿ࡽ࡞ࡿ」㞧࡞཯ᛂ࡛ࡍࡀࠊග࢚ࢿࣝࢠ࣮ࢆᤊ࠼ࡿࢫࢸࢵࣉ࡟ࡣࠊග໬Ꮫ⣔ ,ࠊග໬Ꮫ⣔ ,, ࡜࿧ࡤࢀࡿ㸰ࡘࡢⰍ⣲ࢱࣥࣃࢡ㉁」ྜయࡀ୺せ࡞ᙺ๭ࢆᯝࡓࡋࡲࡍࠋࡇࡢ㸰ࡘࡢග໬Ꮫ⣔ࡢ㐃ᦠࡣගྜᡂ཯ᛂ඲
యࡢຠ⋡ࢆᕥྑࡍࡿ㔜せ࡞ၥ㢟࡛ࡍࠋࠕࢫࢸ࣮ࢺ㑄⛣ࠖ࡜࿧ࡤࢀࡿࡇࡢ㐃ᦠࡢࢥࣥࢭࣉࢺࡣ㸲㸮ᖺ௨ୖ๓࡟Ⓨぢࡉࢀࠊࡑࡢヲ⣽ࢆࡵࡄࡗ࡚ࡣከࡃࡢ◊✲࣭㆟ㄽࡀ⾜ࢃࢀ࡚ࡁࡲࡋࡓࠋ௒ᅇࠊࡇࢀࡲ࡛ࡢᖖ㆑ࢆそࡋࠊࢫࢸ࣮ࢺ㑄⛣ࡣᚑ᮶⪃࠼ࡽࢀ࡚࠸ࡓࡼ࠺࡞ࠕ༢⣧࡞ගࡢ࢔ࣥࢸࢼࡢ⛣ື࡛ࠖࡣ࡞ࡃࠊ
ࠕගࡢ࢔ࣥࢸࢼ
ࡢᛶ㉁ኚ໬࡛ࠖ࠶ࡿࡇ࡜ࡀࢃ࠿ࡾࠊග໬Ꮫ⣔ , ࡜ ,, ࡢ㐃ᦠࡢࣂࣛࣥࢫࡢᔂࢀࡣࠊࡑࢀ࡟ࡼࡾᨵၿࡉࢀ࡚
࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣࠊ⡿ᅜ⛉Ꮫ୍⯡ㄅ 31$6㸦⡿ᅜ⛉Ꮫ࢔࢝ࢹ࣑࣮⣖せ㸧ࡢ㟁Ꮚ㏿ሗ∧࡟㸱᭶㸯㸵᪥࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 158 −

 ᖺ  ᭶  ᪥ⰼࡢⰍ⣲ྜᡂ࡟㛵ࢃࡾࠊⰼࡢⰍࢆ⃰ࡃࡍࡿ᪂ࡋ࠸ࢱࣥࣃࢡ㉁ࢆⓎぢࠥ᪂ࡋ࠸౯್
ࢆᣢࡗࡓⰼࡸᯝᐇࡢရ✀ᨵⰋ࡟ࡘ࡞ࡀࡿྍ⬟ᛶࠥ
Morita, Y., Takagi, K., Fukuchi-Mizutani, M., Ishiguro, K., Tanaka, Y.,
Nitasaka, E., Nakayama, M., Saito, N., Kagami, T., Hoshino, A., and Iida, S.
(2014). A chalcone isomerase-like protein enhances flavonoid production andflower pigmentation. Plant Journal 78, 294-304.
ⰼࡢከࡃࡣ࢔ࣥࢺࢩ࢔ࢽࣥ࡜࠸࠺Ⰽ⣲࡟ࡼࡗ࡚ᙬࡽࢀ࡚࠸ࡲࡍࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡢ᳃⏣⿱ᑗ◊✲ဨ㸦⌧㤶ᕝ኱Ꮫ㸧ࠊᫍ㔝ᩔຓᩍࡽࡣࠊࢧࣥࢺ࣮ࣜࢢ࣮ࣟࣂࣝ࢖ࣀ࣮࣋ࢩࣙࣥࢭࣥࢱ࣮ᰴᘧ఍♫ࠊ㎰◊ᶵᵓⰼࡁ◊✲ᡤ࡞࡝࡜ඹྠ࡛ࠊࡇࡢ࢔ࣥࢺࢩ࢔ࢽࣥࢆ⏕⏘ࡍࡿຠ⋡ࢆ㧗ࡵ࡚ࠊⰼࡢⰍࢆ⃰ࡃࡍࡿ᪂ࡋ࠸ࢱࣥࣃࢡ㉁ࢆⓎぢࡋࠊ()3㸦(QKDQFHURI)ODYRQRLG3URGXFWLRQ㸦ࣇࣛ࣎ࣀ࢖ࢻ⏕⏘ಁ㐍ᅉᏊ㸧㸧࡜ྡ௜ࡅࡲࡋࡓࠋ
()3ࡣࠊ()3 ࡀാ࠿࡞࠸ሙྜ࡟ẚ࡭࡚࢔ࣥࢺࢩ࢔ࣥࡢ⏕⏘ຠ⋡ࢆ㸱ಸ⛬ᗘ࡟㧗ࡵࡲࡍࠋࡲࡓ◊✲ࢢ࣮ࣝࣉࡣࠊࡇࡢ ()3 ࡀ࢔ࢧ࢞࢜ࡔࡅ࡛࡞ࡃ࣌ࢳࣗࢽ࢔࡜ࢺࣞࢽ࢔࡟ࡶᏑᅾࡋࠊࡑࢀࡽࡢാࡁࢆᢚ࠼ࡿ࡜ⷧ࠸
ⰼࡀဏࡃࡇ࡜ࠊ᭦࡟ ()3 ࡀ࢔ࣥࢺࢩ࢔ࢽࣥࡔࡅ࡛࡞ࡃࠊ࡯࠿࡟ࡶ↓Ⰽࡢࣇࣛ࣎ࣀ࢖ࢻ㸦ࣇࣛ࣎ࣥ࡜ࣇࣛ
࣎ࣀ࣮ࣝ㸧ࢆసࡿຠ⋡ࡶ㧗ࡵ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ()3 ࢱࣥࣃࢡ㉁ࡢ◊✲ࢆ㐍ࡵࡿࡇ࡜࡛ࠊ
࢔ࣥࢺࢩ࢔ࢽࣥࡸࣇࣛ࣎ࣀ࢖ࢻࡢྵ᭷㔞ࡢㄪ⠇ࡀྍ⬟࡟࡞ࢀࡤࠊ᪂ࡓ࡞౯್ࢆࡶࡗࡓⰼࡸᯝᐇࡢရ✀㛤Ⓨ࡟ᛂ⏝ࡉࢀࡿࡇ࡜ࡀᮇᚅࡉࢀࡲࡍࠋࡇࡢᡂᯝࡣࠊ ᭶  ᪥࡟᳜≀Ꮫᑓ㛛ㄅ 7KH3ODQW-RXUQDO 㟁Ꮚ∧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸୰᪥᪂⪺ 㠃ࠊᮾᾏឡ▱᪂⪺ 㠃ࠊ᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ:HE6FLHQFH
3RUWDOࠊ:HE࣐࢖ࢼࣅࠊ໬Ꮫᕤᴗ᪥ሗ 㠃ࠊ:HEB⏘⤒ࢽ࣮ࣗࢫࠊἈ⦖ࢱ࢖࣒ࢫ
㠃ࠊᮾዟ᪥ሗ 㠃ࠊ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧୰᪥᪂⪺ 㠃− 159 −

 ᖺ  ᭶  ᪥63,* ࡀ %'1) ࡢࣉࣟࢭࢩࣥࢢࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࢆⓎぢSuzuki, R., Matsumoto, M., Fujikawa, A., Kato, A., Kuboyama, K., Yonehara, K.,
Shintani, T., Sakuta, H., and Noda, M. (2014). SPIG1 negatively regulates
BDNF maturation. Journal of Neuroscience 34, 3429-3442.
⬻⏤᮶⚄⤒ᰤ㣴ᅉᏊ %'1) ࡣࠊ⚄⤒⣽⬊ࡢ⏕Ꮡࡸศ໬ࠊࡉࡽ࡟⚄⤒ᅇ㊰ࡢᙧᡂࡸグ᠈࣭Ꮫ⩦ࡢᇶ┙࡛࠶ࡿ⚄⤒ࢩࢼࣉࢫྍረᛶࡢㄪ⠇࡟㛵ࢃࡿ㔜せ࡞ศἪᛶᅉᏊ࡛ࡍࠋᚑࡗ࡚ࠊࡑࡢศἪ␗ᖖࡸᶵ⬟୙඲ࡣࠊ࠺
ࡘ⑓ࠊ⤫ྜኻㄪ⑕࡜࠸ࡗࡓ⚄⤒⑌ᝈࡢཎᅉ࡜࡞ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡲࡍࠋ%'1) ࡣࠊ⚄⤒⣽⬊ෆ࡛๓㥑య%'1) ࡜ࡋ࡚ྜᡂࡉࢀࡓᚋࠊศἪ๓࠶ࡿ࠸ࡣศἪᚋ࡟ࣉࣟࢸ࢔࣮ࢮ࡟ࡼࡾษ᩿ಟ㣭ࢆཷࡅ࡚ࠊᡂ⇍య %'1)࡟࡞ࡾࡲࡍ㸦ࡇࡢ㐣⛬ࢆࣉࣟࢭࢩࣥࢢ࡜࿧ࡧࡲࡍ㸧ࠋࡇࢀࡲ࡛࡟ࠊࣉࣟࢭࢩࣥࢢࢆㄪ⠇ࡍࡿ௙⤌ࡳ࡟ࡘ࠸࡚ࡣ༑ศ᫂ࡽ࠿࡟ࡉࢀ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤ࣭⤫ྜ⚄⤒⏕≀Ꮫ◊✲㒊㛛ࡢ㕥ᮌுᏊ◊✲ဨ࡜㔝⏣ᫀᬕᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊࢽ࣡ࢺࣜཬࡧ࣐࢘ࢫࢆ⏝࠸ࡓ◊✲࠿ࡽࠊ%'1) ࡢࣉࣟࢭࢩࣥࢢ
ࡀ 63,* ࡜࠸࠺ࢱࣥࣃࢡ࡟ࡼࡗ࡚ไᚚࡉࢀ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋᮏ◊✲ᡂᯝࡣࠊ ᖺ  ᭶ ᪥࡟⡿ᅜ⚄⤒⛉Ꮫ఍ㄅ 7KH-RXUQDORI1HXURVFLHQFH ࡟࢜ࣥࣛ࢖ࣥᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸:HE࣐࢖ࢼࣅࠊ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃

− 160 −

 ᖺ  ᭶  ᪥࢜ࢪࢠࢯ࢘ࡢ㑇ఏᏊ᧯స࡟ᡂຌ᳜≀ࡢ㐠ືࡢ௙⤌ࡳゎ᫂࡬ࡢ㘽ᢏ⾡ࡢ㛤ⓎMano, H., Fujii, T., Sumikawa, N., Hiwatashi, Y., and Hasebe, M. (2014).
Development of an Agrobacterium-mediated stable transformation method forthe sensitive plant Mimosa pudica. PLOS ONE 9, e97211.
᳜≀ࡣ࡯࡜ࢇ࡝ືࡁࡲࡏࢇࡀࠊ࢜ࢪࢠࢯ࢘ࡣ౛እ࡛ࠊࡉࢃࡿ࡜࡯ࢇࡢᩘ⛊ࡢ࠺ࡕ࡟ⴥࡀ࠾㎡൤ࢆࡋࡓࡼ
࠺࡟㛢ࡌ࡚ࡋࡲ࠸ࡲࡍࠋ࠾㎡൤㐠ືࡢ௙⤌ࡳࡸ㐍໬ࢆㄪ࡭ࡿࡓࡵ࡟ࡣࠊືࡁ࡟㛵ಀࡋࡓ㑇ఏᏊࢆㄪ࡭ࡿᚲせࡀ࠶ࡾࡲࡍࡀࠊࡇࢀࡲ࡛࢜ࢪࢠࢯ࢘ࡢ㑇ఏᏊࢆ᧯సࡍࡿࡇ࡜ࡣ࡛ࡁࡲࡏࢇ࡛ࡋࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡢ┿㔝ᘯ᫂◊✲ဨࠊ㛗㇂㒊ගὈᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊᢏ⾡ᨵⰋࡢ⤖ᯝࠊ࢜ࢪࢠࢯ࢘ࡢ㑇ఏᏊ᧯స࡟ୡ⏺࡛ึࡵ࡚ᡂຌࡋࡲࡋࡓࠋ㑇ఏᏊᑟධ࡟㛵ࡋ࡚ࡣࠊ͆࢔ࢢࣟࣂࢡࢸ࣒͇ࣜ࢘࡜࠸࠺⣽⳦ࡢຊࢆ೉ࡾ
ࡿ᪉ἲࢆ⏝࠸ࠊ᳜≀ࡢ⤌⧊࡜࢔ࢢࣟࣂࢡࢸ࣒ࣜ࢘ࢆ୍⥴࡟ᇵ㣴ࡍࡿ㝿࡟ᇵᆅࡢ S+ ࢆᏳᐃ໬ࡉࡏࡿࡇ࡜ࡀࠊ
㑇ఏᏊᑟධࡢຠ⋡ࢆ኱ࡁࡃୖ᪼ࡉࡏࡿࡇ࡜ࢆぢฟࡋࡲࡋࡓࠋࡲࡓࠊᏊⴥࡢ௜ࡅ᰿࡟࠶ࡓࡿ͆Ꮚⴥ⠇͇ࢆ
ฟⓎᮦᩱ࡜ࡋ࡚⏝࠸ࡿࡇ࡜࡟ࡼࡾࠊ᳜≀యࡢ෌ᙧᡂࡀ㧗࠸ຠ⋡࡛㉳ࡇࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋࡇ࠺ࡋࡓ
୍㐃ࡢᕤኵ࡟ࡼࡾࠊ඲㌟ࡢ⣽⬊࡛㑇ఏᏊࢆ᧯సࡍࡿࡇ࡜ࡀྍ⬟࡟࡞ࡾࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊ᪥ᮏ᫬㛫㸰᭶㸯㸱᪥࡟⛉Ꮫ㞧ㄅ 3/2621( ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸୰᪥᪂⪺㸦ኤ㸧 㠃ࠊಙ⃰ẖ᪥᪂⪺㸦ኤ㸧 㠃ࠊᮾᾏឡ▱᪂⪺ 㠃ࠊ
ᮅ᪥᪂⪺ 㠃ࠊబ㈡᪂⪺ 㠃ࠊឡ፾᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧ᮅ᪥᪂⪺ 㠃− 161 −

 ᖺ  ᭶  ᪥㟷࠿ࡽ㉥࡬ ࠥ࣌ࢳࣗࢽ࢔ࡢⰼⰍࢆㄪ⠇ࡍࡿ㑇ఏᏊࡢⓎぢࠥFaraco, M., Spelt, C., Bliek, M., Verweij, W., Hoshino, A., Espen, L., Prinsi, B.,
Jaarsma, R., Tarhan, E., de Boer, A.H., Di Sansebastiano, G.-P., Koes, R., andQuattrocchio, F.M. (2014). Hyperacidification of vacuoles by the combined
action of two different P-ATPases in the tonoplast determines flower color. Cell
Reports 6, 32-43.
࢔࣒ࢫࢸࣝࢲ࣒⮬⏤኱Ꮫ㸦࢜ࣛࣥࢲ㸧ࡢ 0DULDQQD)DUDFRࠊ)UDQFHVFD04XDWWURFFKLR ༤ኈࡽ࡜ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᫍ㔝ᩔຓᩍ࡞࡝࠿ࡽ࡞ࡿ◊✲ࢢ࣮ࣝࣉࡣࠊ3+ ࡜ 3+ ࡜࠸࠺ᾮ⬊⭷࡟Ꮡᅾࡍࡿ  ࡘࡢ࣏ࣥࣉࢱࣥࣃࢡ㉁ࡀ࣌ࢳࣗࢽ࢔ࡢⰼࢆ㉥ࡃࡋ࡚࠾ࡾࠊࡇࢀࡽࡢ࣏ࣥࣉࡀᶵ⬟ࡋ࡞ࡃ࡞ࡿ࡜ⰼࡀ㟷ࡃ࡞ࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋ࣌ࢳࣗࢽ࢔ࡢⰼࡢⰍࡣࠊ⣽⬊ࡢᾮ⬊ෆ࡟ྵࡲࢀࡿ࢔ࣥࢺࢩ࢔ࢽࣥ࡜࿧ࡤࢀࡿ S+ ࡟౫Ꮡࡋ࡚ⰍࡀኚࢃࡿⰍ⣲࡟ࡼࡗ࡚Ỵࡲࡾࡲࡍࠋ◊✲ࢢ࣮ࣝࣉࡣࠊ࣏ࣥࣉࢱࣥࣃࢡ㉁ࡢ 3+ ࡜ 3+ ࡟ࠊ࢔ࣥࢺ
ࢩ࢔ࢽࣥࡀྵࡲࢀ࡚࠸ࡿᾮ⬊ࡢ S+ ࢆୗࡆࡿ㸦㓟ᛶ໬ࡍࡿ㸧ᶵ⬟ࡀ࠶ࡿࡇ࡜ࢆド᫂ࡋࡲࡋࡓࠋࡑࡋ࡚ࠊࡇ
ࢀࡽࡀṇᖖ࡟ᶵ⬟ࡋ࡚ᾮ⬊ෆࡢ S+ ࡀపࡃ࡞ࡿ࡜ࠊ࢔ࣥࢺࢩ࢔ࢽࣥࡣ㉥ࡃⓎⰍࡋ࡚ⰼࡣ㉥Ⰽ࡟࡞ࡿࡇ࡜ࡸࠊ
✺↛ኚ␗࡟ࡼࡾ 3+ ࡸ 3+ ࡢᶵ⬟ࡀኻࢃࢀࡿ࡜ࠊᾮ⬊ෆࡢ S+ ࡀ㧗ࡃ࡞ࡗ࡚ࡋࡲ࠺ࡓࡵ࡟ⰼࡣ㟷Ⰽ࡟࡞ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡇࡢࡼ࠺࡞ᾮ⬊ෆࡢ S+ ࢆㄪᩚࡍࡿ᪂ࡋ࠸௙⤌ࡳࡣࠊ࡯࠿ࡢⰼࡸᯝᐇ࡞࡝࡛ࡶ
ാ࠸࡚࠸ࡿྍ⬟ᛶࡀ࠶ࡾࡲࡍࠋࡇࡢ◊✲ᡂᯝࡣ⏕࿨⛉Ꮫᑓ㛛ㄅ &HOO5HSRUWV㸦 ᖺ  ᭶  ᪥ྕ㸧࡟
࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸⛉Ꮫ᪂⪺ 㠃ࠊ୰᪥᪂⪺ 㠃ࠊ໬Ꮫᕤᴗ᪥ሗ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 162 −

 ᖺ  ᭶  ᪥㓟໬ࡋࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮࡟ࡼࡗ࡚㑅ᢥⓗ࡟ศゎࡉࢀࡿ
Shibata, M., Oikawa, K., Yoshimoto, K., Kondo, M., Mano, S., Yamada, K.,
Hayashi, M., Sakamoto, W., Ohsumi, Y., and Nishimura, M. (2013). Highly
oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis.
Plant Cell 25, 4967-4983.
᳜≀ࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣࠊ
ࠕ⬡⫫㓟ࡢศゎࠖࠊࠕග࿧྾ࠖࠊ
ࠕ᳜≀࣍ࣝࣔࣥࡢྜᡂࠖ࡜࠸ࡗࡓ᳜≀ࡢ⏕⫱࡟࡜ࡗ࡚㠀ᖖ࡟㔜せ࡞௦ㅰ཯ᛂࡀ⾜ࢃࢀࡿ⣽⬊ෆᑠჾᐁࡢ୍ࡘ࡛ࡍࠋ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ෆ࡛⾜ࢃࢀࡿ௦ㅰ
ࡣࠊ㐣㓟໬Ỉ⣲ࡀ⏘⏕ࡉࢀࡿ࡜࠸࠺≉ᚩࡀ࠶ࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⮬యࡶᚎࠎ࡟㓟໬࡟ࡼࡿࢲ࣓࣮ࢪࢆ
ཷࡅࡲࡍࠋ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤ㧗ḟ⣽⬊ᶵᵓ◊✲㒊㛛ࡢᰘ⏣⨾ᬛኴ㑻኱Ꮫ㝔⏕ࠊཬᕝ࿴⪽◊✲ဨ㸦⌧ࠊ᪂₲኱Ꮫ㎰Ꮫ㒊㸧࠾ࡼࡧすᮧᖿኵᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊࢩࣟ࢖ࢾࢼࢬࢼ࡟࠾࠸࡚ࠊࢲ࣓࣮ࢪ
ࢆཷࡅࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ࣮࢜ࢺࣇ࢓ࢪ࣮࡜࠸࠺௙⤌ࡳ࡟ࡼࡗ࡚㑅ᢥⓗ࡟ศゎࢆཷࡅ࡚࠸ࡿࡇ࡜ࢆ♧ࡋࠊ࣮࢜ࢺࣇ࢓ࢪ࣮ࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢရ㉁⟶⌮ᶵᵓ࡜ࡋ࡚ᶵ⬟ࡋ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ
ࡇࡢᡂᯝࡣࠊ᳜≀⛉Ꮫᑓ㛛ㄅ 7KH3ODQW&HOO ᖺ  ᭶  ᪥ྕ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋࡲࡓࠊྠㄅᕳ
㢌࡛ᮏ◊✲ࡀὀ┠グ஦࡜ࡋ࡚⤂௓ࡉࢀ࡚࠸ࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 ᪥ᮏ⤒῭᪂⪺ 㠃ࠊ :HE᪥ᮏ⤒῭᪂⪺ ᖺ  ᭶  ᪥㸦᭶㸧᪥ᮏ⤒῭᪂⪺ 㠃

− 163 −

 ᖺ  ᭶  ᪥㟋㛗㢮኱⬻⓶㉁㡿㔝࡛≉ᐃࡢ㑇ఏᏊࡢ 21㸭2)) ࡀㄪ⠇ࡉࢀࡿ௙⤌ࡳࡢゎ᫂
Hata, K., Mizukami, H., Sadakane, O., Watakabe, A., Ohtsuka, M., Takaji, M.,
Kinoshita, M., Isa, T., Ozawa. K., and Yamamori, T. (2013). DNA methylationand methyl-binding proteins control differential gene expression in distinct
cortical areas of macaque monkey. J. Neurosci. 33, 19704-19714.
⏿ඞ௓◊✲ဨ࡜ᒣ᳃ဴ㞝ᩍᤵࡽࡣࠊ࣐࢝ࢡࢨࣝࡢ㐃ྜ㔝࡛ࡣ 21 ࡟࡞ࡾࠊどぬ㔝࡛ࡣ 2)) ࡟࡞ࡿ㑇ఏᏊࡢ㡿㔝≉␗ⓗ࡞Ⓨ⌧ㄪ⠇ࡢ௙⤌ࡳࡢ୍➃ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ㐃ྜ㔝≉␗ⓗ࡟ 21 ࡟࡞ࡿ㑇ఏᏊࡢࢢ࣮ࣝࣉ
ࡣࠊ㑇ఏᏊⓎ⌧ࢆㄪ⠇ࡍࡿࣉ࣮ࣟࣔࢱ࣮㡿ᇦࡀ㧗࠸๭ྜ࡛࣓ࢳࣝ໬ࡉࢀ࡚࠸ࡿࡇ࡜ࠊ࠾ࡼࡧࠊ࣓ࢳࣝ໬
'1$ ⤖ྜࢱࣥࣃࢡ㉁ࡢ୍ࡘ࡜ࡋ࡚▱ࡽࢀࡿ 0%' ࡀ㐃ྜ㔝≉␗ⓗ࡟Ꮡᅾࡋ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡾࡲࡋࡓࠋࡲ
ࡓࠊ࣓ࢳࣝ໬ࡉࢀࡓࣉ࣮ࣟࣔࢱ࣮㡿ᇦ࡟ 0%' ࡀ⤖ྜࡍࡿࡇ࡜࡛ࠊ㐃ྜ㔝≉␗ⓗ࡟㑇ఏᏊࡀ 21 ࡟࡞ࡿࡇ࡜ࡶ᫂ࡽ࠿࡜࡞ࡾࡲࡋࡓࠋࡇࢀࡣ㟋㛗㢮ࡢ⬻࡟࠾࠸࡚ࠊ㡿㔝≉␗ⓗ࡞㑇ఏᏊࡢ 212)) ࡢㄪ⠇ᶵᵓࡀ᫂ࡽ
࠿࡜࡞ࡗࡓึࡵ࡚ࡢ౛࡛ࡍࠋ௒ᅇࡢᡂᯝࡣࠊ௒ᚋࡢ㟋㛗㢮ࡢ኱⬻⓶㉁ࡢⓎ㐩࡟㛵ࡍࡿ◊✲࡜⢭⚄⑌ᝈࡢ⑓ᅉゎ᫂ࡸ἞⒪➼ࡢ◊✲࡟ࡘ࡞ࡀࡿྍ⬟ᛶࡀᮇᚅࡉࢀࡲࡍࠋࡇࡢᡂᯝࡣࠊ⡿ᅜ⚄⤒⛉Ꮫ఍ㄅ -RXUQDORI
1HXURVFLHQFH㸦ࢪ࣮ࣕࢼࣝ࢜ࣈࢽ࣮ࣗࣟࢧ࢖࢚ࣥࢫ㸧㸰㸮㸯㸱ᖺ㸯㸰᭶㸯㸯᪥ྕ࡟࡚Ⓨ⾲ࡉࢀࠊࠕ7KLV:HHNLQ7KH-RXUQDOࠖ࡜ࡋ࡚⤂௓ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃

− 164 −

 ᖺ  ᭶  ᪥࣓ࢲ࢝࡟࢜ࢫࡢ஧ḟᛶᚩࡀⓎ⌧ࡍࡿ࣓࢝ࢽࢬ࣒ࢆゎ᫂
2JLQR<+LUDNDZD,,QRKD\D.6XPL\D(0L\DJDZD67DWDUD]DNR1
'HQVORZ 0 <DPDGD * DQG ,JXFKL 7   %PS DQG /HI DUH WKHGRZQVWUHDP HIIHFWRUV RI DQGURJHQ VLJQDOLQJ LQ DQGURJHQLQGXFHG VH[FKDUDFWHULVWLFVGHYHORSPHQWLQPHGDND(QGRFULQRORJ\
⏨ᛶ࣍ࣝࣔࣥ ࢔ࣥࢻࣟࢤࣥ ࡣࠊ⏕Ṫჾᐁ࠾ࡼࡧࡑࡢ㝃ᒓჾᐁ࡟࢜ࢫ≉᭷ࡢᙧ㉁Ⓨ⌧ ஧ḟᛶᚩ ࢆㄏᑟࡋࡲࡍࠋࡇࢀࡽࡢᙧ㉁ࡣࠊ࢜ࢫࡀ஺㓄┦ᡭࢆᚓࡿࡓࡵ࡟ᚲせ࡞ᙧ㉁࡛ࡍࠋࡋ࠿ࡋࠊ࢔ࣥࢻࣟࢤࣥ࡟ࡼࡾࠊ
࡝ࡢࡼ࠺࡞㑇ఏᏊࡀ஧ḟᛶᚩⓎ⌧࡟㛵ࢃࡗ࡚࠸ࡿࡢ࠿ࠊࡑࡢ࣓࢝ࢽࢬ࣒ࡢヲ⣽ࡣࡼࡃࢃ࠿ࡗ࡚࠸ࡲࡏࢇ
࡛ࡋࡓࠋ௒ᅇࠊᒸᓮ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮࣭ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭ศᏊ⎔ቃ⏕≀Ꮫ◊✲㒊㛛㸭⥲ྜ◊✲኱Ꮫ㝔኱ᏛࡢⲶ㔝⏤⣖Ꮚຓᩍ࡜஭ཱྀὈἨᩍᤵࡢ◊✲ࢢ࣮ࣝࣉࡣࠊᮾிᕤᴗ኱Ꮫࠊ࿴ḷᒣ┴❧་⛉኱Ꮫࠊࣇࣟࣜࢲ኱Ꮫࠊᅜ❧⎔ቃ◊✲ᡤ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ࣓ࢲ࢝ࡢ࢜ࢫᑼ㫅ࡢங㢌≧✺㉳ᙧᡂࢆࣔࢹ
ࣝ࡜ࡋ࡚ࠊ࢔ࣥࢻࣟࢤࣥࡀⓎ⌧ไᚚࡋ࡚࠸ࡿ㑇ఏᏊࢆⓎぢࡋࠊ࢔ࣥࢻࣟࢤࣥࡀ஧ḟᛶᚩⓎ⌧ࢆไᚚࡍࡿ
ලయⓗ࡞௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣෆศἪᏛᑓ㛛ㄅ (QGRFULQRORJ\ ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 165 −

 ᖺ  ᭶  ᪥࣓ࢲ࢝ࡣືࡁ࡛௰㛫ࢆᘬࡁᐤࡏࡿ

Nakayasu, T., and Watanabe, E. Biological motion stimuli are attractive to
medaka fish. Animal Cognition 2013 Oct. 20.
࣓ࢲ࢝ࡣࠕ࣓ࢲ࢝ࡢᏛᰯࠖ࡜࿧ࡤࢀࡿࡼ࠺࡟ࠊ⩌ࢀࢆࡘࡃࡗ࡚Ὃࡄࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡲࡍࠋᇶ♏⏕≀Ꮫ◊✲ᡤ㸦⚄⤒⏕⌮Ꮫ◊✲ᐊ㸧ࡢ୰᫆▱኱◊✲ဨ࡜Ώ㎶ⱥ἞෸ᩍᤵࡣࠊࣂ࢖࢜ࣟࢪ࣮࢝ࣝࣔࢩ่⃭ࣙࣥ࡜࠸࠺ࠊ⏕≀ࡢືࡁࢆᑡᩘࡢⅬࡢືࡁࡢࡳ࡛⾲⌧ࡍࡿᡭἲࢆୡ⏺࡛ึࡵ࡚㨶㢮࡟ᛂ⏝ࡋࠊ⾜ືゎᯒᐇ㦂ࢆ⾜࠸ࡲࡋࡓࠋࣂ࢖࢜ࣟࢪ࣮࢝ࣝࣔࢩ่⃭ࣙࣥࡣࠊ⮬⏤㐠ືࢆࡍࡿ࣓ࢲ࢝ࢆඖ࡟ࡋࡓࡶࡢࢆྵࡴᵝࠎ࡞ࣃࢱ࣮ࣥࡢࡶࡢࡀ㟁Ꮚィ⟬ᶵ࡟ࡼࡗ࡚సᡂࡉࢀࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ࣓ࢲ࢝ࡣࠊືࡁ࡟ࡼࡗ࡚௰㛫ࢆᘬࡁᐤࡏ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡇࡢᡂᯝ࡟ࡼࡾࠊື≀⾜ືᏛ࡟࠾࠸࡚㔜せ࡞◊✲ࢸ࣮࣐ࡢ୍ࡘ࡛
࠶ࡿ⩌ࢀᙧᡂࡢ◊✲࡟ࠊࠕືࡁࠖ࡜࠸࠺᪂ࡓ࡞どⅬࡀ㔜せᛶࢆᣢࡘࡇ࡜♧ࡉࢀࡲࡋࡓࠋᮏ◊✲ᡂᯝࡣẚ㍑
ㄆ▱⛉Ꮫࡢᑓ㛛ㄅ $QLPDO&RJQLWLRQ ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ୰᪥᪂⪺ 㠃ࠊ :HE࣐࢖ࢼࣅࠊ :HE<$+22ࠊ ᮾᾏឡ▱᪂⪺ 㠃ࠊ᪥ᮏ⤒῭᪂⪺ ኤ  㠃ࠊ :HE1(:6ࠊ ẖ᪥᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦ⅆ㸧୰᪥᪂⪺ 㠃− 166 −

 ᖺ  ᭶  ᪥⤌⧊ࡢ⛣ືࡀ⏕ࡳฟࡍຊࡀ⏕≀ࡢᙧ࡙ࡃࡾࢆᨭ࠼ࡿ

+DUD<1DJD\DPD.<DPDPRWR760DWVXPRWR76X]XNL0DQG8HQR
1  'LUHFWLRQDOPLJUDWLRQRIOHDGLQJHGJHPHVRGHUPJHQHUDWHVSK\VLFDO
IRUFHV ,PSOLFDWLRQ LQ ;HQRSXV QRWRFKRUG IRUPDWLRQ GXULQJ JDVWUXODWLRQ 'HY%LRO
ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭ᙧែᙧᡂ◊✲㒊㛛ࡢཎభ௓◊✲ဨࠊୖ㔝┤ேᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊྡྂᒇᕤᴗ
኱Ꮫ࣭ࣂ࢖࣓࢜࢝ࢽࢡࢫ◊✲ᐊ࡜ඹྠ࡛ࠊ࢔ࣇࣜ࢝ࢶ࣓࢚࢞ࣝࢆࣔࢹࣝ࡜ࡋ࡚ື≀ࡢཎ⭠㝗ධ㐣⛬࡛⏕ࡲࢀࡿ≀⌮ⓗ࡞ຊࡢᙺ๭ࢆゎᯒࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊཎ⭠㝗ධ᫬࡟✚ᴟⓗ࡟⛣ືࡍࡿ⤌⧊࡟ࡼࡗ࡚⏕ࡳฟࡉࢀࡿຊࡢつᶍࡸఏ㐩ࡢᵝᏊࡀ᫂ࡽ࠿࡜࡞ࡾࠊࡉࡽ࡟ࡑࡢ⏕ࡳฟࡉࢀࡓຊࡀࢶ࣓࢚࢞ࣝࡢ⬨⣴ యࡢఙ㛗ࡸ㍈ᙧᡂࢆᢸ࠺୰⬇ⴥᛶࡢᲬ≧⤌⧊ ࢆṇࡋࡃᙧᡂࡍࡿⅭ࡟ᚲせ࡛࠶ࡿࡇ࡜ࢆ᪂ࡓ࡟Ⓨぢࡋࡲࡋࡓࠋ⬨⣴ᙧᡂࡢ࣓࢝ࢽࢬ࣒ࡣࡇࢀࡲ࡛୺࡟㑇ఏᏊࡸศᏊࡢどⅬ࠿ࡽ┒ࢇ࡟◊✲ࡉࢀ࡚ࡁࡲࡋࡓࡀࠊᮏ◊✲ࡣ᪂ࡓ࡟≀⌮ⓗ࡞ຊࡀ⬨⣴ᙧᡂࢆᨭ࠼ࡿ୍ᅉᏊ࡛࠶ࡿࡇ࡜ࢆ♧ࡋࡓ㔜せ࡞ᡂᯝ࡛ࡍࠋࡇࡢᡂᯝࡣࠊ ᖺ ᭶  ᪥࡟Ⓨ⾜ࡢ⡿Ⓨ⏕⏕≀Ꮫ఍ㄅ 'HYHORSPHQWDO%LRORJ\ ㄅ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 167 −

 ᖺ  ᭶  ᪥᳜≀ࡢᡂ㛗࡟ᚲせ࡞⢾ࢱࣥࣃࢡ㉁ࢆࡘࡃࡾࡔࡍ㓝⣲ࢆⓎぢ  ᖺ᮶ࡢㅦࢆゎ᫂Ogawa-Ohnishi, M., Matsushita, W., and Matsubayashi, Y. (2013).
Identification of three hydroxyproline O-arabinosyltransferases in Arabidopsis
thaliana. Nature Chem. Biol. 9, 726-730.
᳜≀ࡢ⣽⬊ࢆྲྀࡾᅖࡴ⣽⬊ቨ୰࡟ࡣࠊື≀࡟ࡣᏑᅾࡋ࡞࠸≉Ṧ࡞⢾㙐ᵓ㐀ࢆᣢࡘ⢾ࢱࣥࣃࢡ㉁ࡀከᩘᏑ
ᅾࡋࠊ⣽⬊ቨᙧᡂ᫬ࡢ㊊ሙࡸ⿵ᙉ๣࡜ࡋ࡚ࡢᙺ๭ࢆᯝࡓࡍࡶࡢࡸࠊ⣽⬊㛫࡛᝟ሗࢆఏ࠼ࡿ࣍ࣝࣔࣥ࡜ࡋ
࡚ᶵ⬟ࡍࡿࡶࡢ࡞࡝ࠊ᳜≀ࡢᡂ㛗࡟ᴟࡵ࡚㔜せ࡞ศᏊ⩌࡛࠶ࡿࡇ࡜ࡀ♧ࡉࢀ࡚ࡁࡲࡋࡓࠋࡇࢀࡽࡢ⢾ࢱ
ࣥࣃࢡ㉁࡟ࡣ࢔ࣛࣅࣀ࣮ࢫ࡜࠸࠺⢾ࡀ㙐≧࡟㐃࡞ࡗ࡚௜ຍࡋ࡚࠸ࡿࡇ࡜ࠊ࠾ࡼࡧࠊ⢾㙐ࡀ௜ຍࡉࢀ࡚ࡣ
ࡌࡵ࡚ࢱࣥࣃࢡ㉁ࡢ࠿ࡓࡕࡀṇࡋࡃ⥔ᣢࡉࢀࡿࡇ࡜ࡀ᫂ࡽ࠿࡟ࡉࢀ࡚࠸ࡲࡋࡓࡀࠊ࢔ࣛࣅࣀ࣮ࢫ࡜࠸࠺
⢾ࢆࢱࣥࣃࢡ㉁࡟௜ຍࡉࡏࡿࡢ࡟ᚲせ࡞㓝⣲ࡣᮍࡔぢࡘ࠿ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤ㸦⣽⬊㛫ࢩࢢࢼࣝ◊✲㒊㛛㸧ࡢᯇᯘ჆ඞᩍᤵ࡜኱す┿⌮◊✲ဨࡽࡣࠊࢩࣟ࢖ࢾࢼࢬࢼࡢ⣽⬊࡟ᚤ㔞ྵࡲࢀࡿࡇࡢ㓝⣲ࢆ⢭〇࣭ྠᐃࡍࡿࡇ࡜࡟ୡ⏺࡛ึࡵ࡚ᡂຌࡋࡲࡋࡓࠋࢩࣟ࢖ࢾࢼࢬࢼ࡟ࡣࡇࡢ㓝⣲ࢆࢥ࣮ࢻࡍ
ࡿ㑇ఏᏊࡀ  ಶ࠶ࡾࡲࡋࡓࡀࠊ㑇ఏᏊ᧯స࡟ࡼࡾࡇࢀࡽࡀാ࠿࡞࠸ࡼ࠺࡟ࡋࡓ᳜≀య࡛ࡣࠊ⣽⬊ቨࡀⷧࡃࡸࢃࡽ࠿ࡃ࡞ࡗࡓࡾࠊཷ⢭ࡀጉࡆࡽࢀ࡚✀Ꮚࡀ࡛ࡁ࡞ࡃ࡞ࡿ࡞࡝ࠊᡂ㛗࡟ᵝࠎ࡞␗ᖖࡀ⏕ࡌࡿࡇ࡜ࡀ
ศ࠿ࡾࡲࡋࡓࠋ᳜≀ࡢᡂ㛗࡟࠾ࡅࡿ⢾ࢱࣥࣃࢡ㉁⩌ࡢ㔜せᛶࢆ┤᥋ⓗ࡟♧ࡋࡓึࡵ࡚ࡢ౛࡛ࡍࠋࡇࡢᡂ
ᯝࡣࠊ㸷᭶㸯㸳᪥࡟⡿ᅜ⛉Ꮫㄅ 1DWXUH&KHPLFDO%LRORJ\ 㟁Ꮚ∧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ୰᪥᪂⪺ 㠃ࠊ ᮾᾏឡ▱᪂⪺ 㠃ࠊ :HE<$+22ࠊ :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺ 㠃ࠊ ໬Ꮫᕤᴗ᪥ሗ♫ 㠃 ᖺ  ᭶  ᪥㸦᭶㸧୰᪥᪂⪺ 㠃− 168 −

 ᖺ  ᭶  ᪥࣐࣓⛉᳜≀ࡢ᰿⢏ࡢᩘࢆไᚚࡍࡿࢩࢢࢼࣝศᏊࡢᵓ㐀ࢆゎ᫂Okamoto, S., Shinohara, H., Mori, T., Matsubayashi, Y.,* and Kawaguchi, M.*(co-corresponding authors) (2013). Root-derived CLE glycopeptides control
nodulation by direct binding to HAR1 receptor kinase. Nature Commun. 4,2191.
ࢲ࢖ࢬࡸ࢖ࣥࢤࣥ࡞࡝ࡢ࣐࣓⛉᳜≀ࡣࠊᬑ㏻ࡢ᳜≀ࡀ⏕⫱࡛ࡁ࡞࠸ࡼ࠺࡞㣴ศࡢᑡ࡞࠸ᅵᆅ࡛ࡶ⏕⫱࡛ࡁࡲࡍࠋࡇࢀࡣ࣐࣓⛉᳜≀ࡀࠊ᰿⢏࡜࠸࠺ࡇࡪ≧ࡢჾᐁࡢ୰࡟ࠊ✵Ẽ୰ࡢ❅⣲ࢆᰤ㣴ศ࡜ࡋ࡚฼⏝ࡍࡿ⬟ຊࢆᣢࡘ᰿⢏⳦࡜࠸࠺ᚤ⏕≀ࢆఫࡲࢃࡏ࡚࠸ࡿࡓࡵ࡛ࡍࠋࡇࡢࡋࡃࡳࢆ࠺ࡲࡃ⥔ᣢࡍࡿࡓࡵ࡟ࠊ࣐࣓
⛉᳜≀ࡣ⎔ቃ࡟ᛂࡌ࡚᰿⢏ࡢᩘࢆㄪ⠇ࡋ࡚࠸ࡿࡢ࡛ࡍࡀࠊࡇࡢㄪ⠇࡟㛵ࢃࡿࢩࢢࢼࣝศᏊ࡟ࡘ࠸࡚ࡣࠊ ᖺ௨ୖࡶ๓࡟ࡑࡢᏑᅾࡀண᝿ࡉࢀ࡞ࡀࡽࡶࠊศᏊᐇయࡣㅦ࡟ໟࡲࢀ࡚࠸ࡲࡋࡓࠋ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢ◊✲ࢢ࣮ࣝࣉ㸦ᒸᮏᬡ◊✲ဨࠊᯇᯘ჆ඞᩍᤵࠊᕝཱྀṇ௦ྖᩍᤵࡽ㸧ࡣࠊ᳜≀ෆ࡟ࡈࡃᚤ㔞ྵࡲࢀࡿࡇࡢࢩࢢࢼࣝศᏊࢆᤊ࠼ࠊࡑࡢᵓ㐀ࢆゎ᫂ࡍࡿࡇ࡜࡟ୡ⏺࡛ึࡵ࡚ᡂຌࡋࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊᑗ᮶ࠊ
✵Ẽ୰ࡢ❅⣲ࢆᰤ㣴ศ࡜ࡋ࡚฼⏝ࡍࡿ⬟ຊࢆ࣐࣓⛉௨እࡢ᳜≀࡟ࡶ௜୚ࡍࡿࡓࡵࡢᇶ♏◊✲ࡢࡦ࡜ࡘ࡜
ࡋ࡚኱ࡁ࡞๓㐍࡛ࡍࠋࡇࡢᡂᯝࡣࠊ㸶᭶㸯㸰᪥࡟⛉Ꮫ㞧ㄅ 1DWXUH&RPPXQLFDWLRQV ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ᮅ᪥᪂⪺ 㠃ࠊ ୰᪥᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦ⅆ㸧ᮅ᪥᪂⪺ 㠃

− 169 −

 ᖺ  ᭶  ᪥ⴥ⥳యࡢ≧ែ࡟ᛂࡌ࡚ⴥࡀᙧࢆኚ࠼ࡿ㝿ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂
Tameshige, T., Fujita, H., Watanabe, K., Toyokura, K. Kondo, M., Tatematsu, K.,
Matsumoto, N., Tsugeki, R., Kawaguchi, M., Nishimura, M., and Okada, K.
(2013). Pattern dynamics is adaxial-abaxial specific gene expression are
modulated by a plastid retrograde signal during Arabidopsis thaliana leaf
development. PLoS Genetics 9, e1003655.
ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᒸ⏣ΎᏕ๓ᡤ㛗࡜∔㔜ᡯぬ◊✲ဨࡽࡣࠊⴥ⥳యࢤࣀ࣒ࡢാࡁࡀᢚ࠼ࡽࢀࡿ࡜ࠊⴥࡢ
⾲ഃ⤌⧊ࡢᛶ㉁ࢆỴࡵࡿ㑇ఏᏊࡀṇᖖ࡞ࣃࢱ࣮࡛ࣥാ࠿࡞ࡃ࡞ࡾࠊⴥཎᇶෆ㒊࡛⾲ഃ࡜⿬ഃࡢᛶ㉁ࢆᣢ
ࡘ⣽⬊ࡢศᕸࡢࣂࣛࣥࢫࡀᔂࢀ࡚ࠊⴥࡢᶓ᪉ྥ࡬ࡢᖜᗈ࠸ᡂ㛗ࡀጉࡆࡽࢀ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋ
ࡓࠋࡇࢀࡽࡢⓎぢ࠿ࡽࠊⴥ⥳యࢤࣀ࣒ࡢാࡁࡀࠊⴥ⥳యࡢⓎ㐩ࡔࡅ࡛࡞ࡃࠊⴥࡢᙧࢆỴࡵࡿୖ࡛ࡶ㔜せ࡞ᙺ๭ࢆᢸ࠺ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊ㸵᭶㸰㸳᪥࡟⡿ᅜ⛉Ꮫ㞧ㄅࠕ3/26*HQHWLFVࠖ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋࡲࡓࠊࡇࡢㄽᩥࡣ 3/26*HQHWLFV㸵᭶ྕࡢ &RYHU㸦⾲⣬㸧࡜ࡋ࡚⤂௓ࡉࢀ࡚࠸ࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 170 −

 ᖺ  ᭶  ᪥࣐࢘ࢫ⬇ࡢయ࡙ࡃࡾࡢᵝᏊࢆ㧗⢭ᗘ࡛ᤊ࠼ࡿࡇ࡜࡟ᡂຌ

Ichikawa, T., Nakazato, K., Keller, P.J., Kajiura-Kobayashi, H., Stelzer, E.H.,
Mochizuki, A., and Nonaka, S. (2013). Live imaging of whole mouse embryos
during gastrulation: migration analyses of epiblast and mesodermal cells. PLoS
ONE 8, e64506.
ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᕷᕝኊᙪ◊✲ဨ࡜㔝୰ⱱ⣖෸ᩍᤵࡽࡢࢢ࣮ࣝࣉࡣࠊ⌮໬Ꮫ◊✲ᡤࠊḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸦(0%/㸧࡜ࡢඹྠ◊✲࡟ࡼࡾࠊࣛ࢖ࢺࢩ࣮ࢺ㢧ᚤ㙾ࡢ୍✀࡛࠶ࡿࢹࢪࢱࣝࢫ࢟ࣕࣥࣛ࢖ࢺࢩ࣮ࢺ
ᆺ㢧ᚤ㙾㸦'6/0㸧ࢆᇶ♏⏕≀Ꮫ◊✲ᡤ࡟ᑟධࡋࡲࡋࡓࠋ'6/0 ࡣࡇࢀࡲ࡛࡟ࡶࢮࣈࣛࣇ࢕ࢵࢩࣗ⬇࡞࡝ࡢ◊✲࡟౑ࢃࢀ࡚ࡁࡓ୍᪉ࠊ࣐࢘ࢫ⬇࡟౑⏝ࡍࡿ࡟ࡣヨᩱࡢಖᣢ᪉ἲ࡞࡝ࡢၥ㢟ࡀ࠶ࡗࡓࡢ࡛ࡍࡀࠊ᪂ࡓ
࡞ᡭἲࢆ㛤Ⓨࡍࡿࡇ࡜࡛ࡇࡢၥ㢟ࢆゎỴࡋࠊᇶᮏⓗ࡞యࡢᵓ㐀ࡀసࡽࢀࡿ᫬ᮇ࡛࠶ࡿཎ⭠㝗ධᮇ⬇ࡢ࣐࢘ࢫ⬇ࢆࠊ⏕ࡁࡓࡲࡲ୸ࡈ࡜ࠊ௒ࡲ࡛࡟࡞࠸㧗᫬㛫ゎീᗘ࡛㛗᫬㛫ほᐹࡍࡿࡇ࡜࡟ᡂຌࡋࠊࡇࡢ᫬ᮇࡢ
⣽⬊⛣ືࡢᵝᏊࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡉࡽ࡟⌮໬Ꮫ◊✲ᡤࡢᮃ᭶ᩔྐ୺௵◊✲ဨࠊ୰㔛◊୍◊✲ဨ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊほᐹ࡟ࡼࡗ࡚ᚓࡽࢀࡓ  ḟඖ㸩᫬㛫ࡢ኱ᐜ㔞ࢹ࣮ࢱ࠿ࡽಶࠎࡢ⣽⬊ࢆ㏣㊧ࡍࡿࢯࣇࢺ
࢙࢘࢔ࢆ㛤Ⓨࡋࠊ࢚ࣆࣈࣛࢫࢺࡢ᰾࡜୰⬇ⴥ⣽⬊ࡢ㐠ືࣃࢱ࣮ࣥࢆゎᯒࡋࡲࡋࡓࠋࡇࡢ⤖ᯝࡣ⡿ᅜ⛉Ꮫ㞧ㄅࠕ3/R62QHࠖ㟁Ꮚ∧㸵᭶㸶᪥ྕ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅࠊ ᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦ᮌ㸧᪥⤒⏘ᴗ᪂⪺ 㠃− 171 −

 ᖺ  ᭶  ᪥
55373 ࢧࣈࣇ࢓࣑࣮ࣜࡀከᩘࡢ 537. ࢆᇶ㉁࡟ࡋ࡚࠸ࡿࡇ࡜ࢆⓎぢ
6DNXUDED - 6KLQWDQL 7 7DQL 6 DQG 1RGD 0   6XEVWUDWH VSHFLILFLW\ RI 5
UHFHSWRUOLNH SURWHLQW\URVLQH SKRVSKDWDVH VXEIDPLO\ WRZDUGV UHFHSWRU SURWHLQW\URVLQH
NLQDVHV-%LRO&KHP
ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭⤫ྜ⚄⤒⏕≀Ꮫ◊✲㒊㛛ࡢ㔝⏣ᫀᬕᩍᤵࡢ◊✲ࢢ࣮ࣝࣉࡣࠊཷᐜయᆺࢱࣥࣃࢡ㉁ࢳࣟࢩࣥ⬺ࣜࣥ㓟໬㓝⣲ 5373 ࡢ 5 ࢧࣈࣇ࢓࣑࣮ࣜ࡟ᒓࡍࡿศᏊ⩌ࡀࠊከᩘࡢཷᐜయᆺࢱࣥࣃࢡ㉁ࣜࣥ
㓟໬㓝⣲ 537. ࢆᇶ㉁ศᏊ࡜ࡋࠊࡑࢀࡽࡢάᛶࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࢆぢฟࡋࡲࡋࡓࠋ537. ࡣ⏕యෆࡢ᝟ሗఏ㐩࡟࠾࠸࡚㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠾ࡾࠊ537. ࡢ␗ᖖ࡟ࡼࡗ࡚⒴ࡸᡂே⑓࡞࡝ࡢᵝࠎ࡞⑌ᝈࢆⓎ⑕ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡲࡍࠋ௒ᅇࡢᡂᯝࡣࠊ55373 ࢧࣈࣇ࢓࣑࣮ࣜศᏊࡢ⏕⌮ᶵ⬟ࢆ᫂ࡽ࠿࡟ࡍࡿୖ࡛ࡢ㔜せ࡞ᇶ┙࡜࡞ࡿ࡜࡜ࡶ࡟ࠊ55373 ࢧࣈࣇ࢓࣑࣮ࣜࡢάᛶไᚚࢆ㏻ࡋ࡚ࠊࡑࢀࡽࡢᇶ㉁࡜࡞ࡿ 537.
ࡢάᛶࢆไᚚࡍࡿ࡜࠸࠺᪂ࡋ࠸ᢏ⾡ࡢ㛤Ⓨ࡟ࡘ࡞ࡀࡿࡶࡢ࡛ࡍࠋᮏ◊✲ᡂᯝࡣࠊ-RXUQDORI%LRORJLFDO&KHPLVWU\ ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 172 −

 ᖺ  ᭶  ᪥⣽⬊ศ⿣࡛௙ษࡾࢆసࡿ㐣⛬ࢆぢࡿࡇ࡜࡟ᡂຌ
0XUDWD76DQR76DVDEH01RQDND6+LJDVKL\DPD7+DVH]DZD6
0DFKLGD < DQG +DVHEH 0   0HFKDQLVP RI PLFURWXEXOH DUUD\
H[SDQVLRQLQWKHF\WRNLQHWLFSKUDJPRSODVW1DWXUH&RPPXQLFDWLRQV᳜≀⣽⬊ࡣ㸯ࡘࡢ⣽⬊ࡢ୰࡟௙ษࡾࢆసࡿࡇ࡜࡟ࡼࡾศ⿣ࡋࡲࡍࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡢ◊✲ࢢ࣮ࣝࣉ㸦ᮧ⏣㝯෸ᩍᤵࠊ㔝୰ⱱ⣖෸ᩍᤵࠊ㛗㇂㒊ගὈᩍᤵ㸧ࡣࠊἲᨻ኱Ꮫ㸦బ㔝ಇኵ෸ᩍᤵ㸧ࠊྡྂᒇ኱Ꮫ㸦ᮾᒣဴஓᩍᤵࠊ➲㒊⨾▱Ꮚ≉௵ຓᩍ㸦⌧࣭ᘯ๓኱Ꮫ෸ᩍᤵ㸧ࠊ⏫⏣Ὀ๎ᩍᤵ㸧ࠊᮾி኱Ꮫ㸦㥅⃝┒୍㑻ᩍᤵ㸧࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ௙ษࡾࡀ࡛ࡁࡿ㐣⛬ࢆ㧗ゎീᗘ᧜ᙳࡍࡿࡇ࡜࡟ୡ⏺࡛ึࡵ࡚ᡂຌࡋࡲࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡣࠊගࡢ㏱㐣⤒㊰࡟ࢩࣜࢥ࣮ࣥ࢜࢖ࣝࢆ⏝࠸ࡓ㢧ᚤ㙾ࢩࢫࢸ࣒ࢆᵓ⠏ࡋࠊ㢧ᚤ㙾ほᐹࡢศゎ⬟ࢆୖࡆࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ⦅ࡲࢀ࡚࠸ࡃ㏵୰ࡢ⧄⥔㸯ᮏ㸯ᮏࡢືࡁࢆ᧜ᙳࡍࡿࡇ࡜࡟ୡ⏺
࡛ึࡵ࡚ᡂຌࡋࠊ⧄⥔ࡀ⦅ࡲࢀ࡚ࡺࡾ࠿ࡈࡀ኱ࡁࡃ࡞ࡿ௙⤌ࡳࡀࢃ࠿ࡾࡲࡋࡓࠋࡺࡾ࠿ࡈࡀ኱ࡁࡃ࡞ࡿ
ࡇ࡜ࡣ⣽⬊ࢆ௙ษࡿཎືຊ࡞ࡢ࡛ࠊ᳜≀⣽⬊ࡀศ⿣ࡍࡿࡓࡵࡢཎືຊࡀ᫂ࡽ࠿࡟࡞ࡗࡓࡇ࡜࡟࡞ࡾࡲࡍࠋ
ࡇࡢᡂᯝࡣࠊ㸴᭶㸯㸵᪥࡟⛉Ꮫ㞧ㄅ 1DWXUH&RPPXQLFDWLRQV ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ᮅ᪥᪂⪺ 㠃ࠊ ᮾᾏឡ▱᪂⪺ 㠃ࠊ ୰᪥᪂⪺ 㠃ࠊ :HE࣐࢖ࢼࣅࠊ :HE<$+22ࠊ ẖ᪥᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃ࠊ ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ ㄞ኎᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦ⅆ㸧ᮅ᪥᪂⪺ 㠃

− 173 −

 ᖺ  ᭶  ᪥⾑⟶ෆ⓶⣽⬊࡛ࡢ㑇ఏᏊⓎ⌧ࢆ  ⣽⬊࡛ࣞ࣋ࣝࢥࣥࢺ࣮ࣟࣝࡍࡿࡇ࡜࡟ᡂຌ

Kimura, E., Deguchi, T., Kamei, Y., Shoji, W., Yuba, S., and Hitomi, J. (2013).
Application of infrared laser to the zebrafish vascular system: gene induction,
tracing, and ablation of single endothelal cells. Arterioscler. Thromb. Vasc. Biol.
33, 1264-1270.
ᒾᡭ་⛉኱Ꮫゎ๗Ꮫㅮᗙᮌᮧⱥ஧ຓᩍ࡜ᇶ♏⏕≀Ꮫ◊✲ᡤ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ட஭ಖ༤≉௵෸ᩍᤵࡽ
◊✲ࢢ࣮ࣝࣉࡣࠊ㉥እ࣮ࣞࢨ࣮↷ᑕ㢧ᚤ㙾ࢆ⏝࠸࡚ࠊࢮࣈࣛࣇ࢕ࢵࢩࣗࡢಶయෆ࡛⾑⟶ෆ⓶⣽⬊ࢆᑐ㇟࡟  ⣽⬊࡛ࣞ࣋ࣝ㑇ఏᏊⓎ⌧ࢆ㧗ຠ⋡࡟ㄏᑟࡍࡿࡇ࡜࡟ୡ⏺࡛ึࡵ࡚ᡂຌࡋࡓࠋட஭ಖ༤≉௵෸ᩍᤵࡽ
ࡀ㛤Ⓨࡋࡓ㉥እ࣮ࣞࢨ࣮↷ᑕ㢧ᚤ㙾㸦,5/(*2LQIUDUHGODVHUHYRNHGJHQHRSHUDWRU㸧ࡣࠊ㉥እ࣮ࣞࢨ࣮ࢆ↷ᑕࡍࡿࡇ࡜࡛ᒁᡤⓗ࡟⣽⬊ࢆࡵ࡚ࠊ⇕ࢩࣙࢵࢡࣉ࣮ࣟࣔࢱ࣮ୗὶࡢ┠ⓗ㑇ఏᏊࡢⓎ⌧ࢆㄏᑟࡍࡿࢩࢫࢸ࣒࡛ࠊ௒ᅇ◊✲ࢢ࣮ࣝࣉࡣࠊࡇࡢࢩࢫࢸ࣒࡟⾑⟶ෆ⓶⣽⬊ࡢ᰾࡛≉␗ⓗ࡟⺯ගࢆⓎࡍࡿ㑇ఏᏊ⤌ࡳ᥮࠼ࢮࣈࣛࣇ࢕ࢵࢩࣗࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ࠊಶయෆࡢ⾑⟶ෆ⓶⣽⬊࡟ຠ⋡ࡼࡃ㉥እ࣮ࣞࢨ࣮ࢆ
↷ᑕࡋࠊ㑇ఏᏊⓎ⌧ࢆㄏᑟ࡛ࡁࡿࢩࢫࢸ࣒ࢆᵓ⠏ࡋࡓࠋᮏ◊✲ᡂᯝࡣࠊ⡿ᅜࡢ⛉Ꮫ㞧ㄅࠗ$UWHULRVFOHURVLV7KURPERVLVDQG9DVFXODU%LRORJ\࠘㸦 ᖺ  ᭶ྕ㸧࡟ᥖ㍕ࡉࢀࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅ



− 174 −

 ᖺ  ᭶  ᪥㐣๫࡞ග࢚ࢿࣝࢠ࣮ࢆᾘཤࡍࡿᐇయࠊගྜᡂࢱࣥࣃࢡ㉁㉸」ྜయࢆⓎぢ
Tokutsu, R., and Minagawa, J. (2013). Energy-dissipative supercomplex ofphotosystem II associated with LHCSR3 in Chlamydomonas reinhardtii. Proc.
Natl. Acad. Sci. USA 110, 10016-10021.
ᇶ♏⏕≀Ꮫ◊✲ᡤ⎔ቃග⏕≀Ꮫ◊✲㒊㛛ࡢᚓὠ㝯ኴ㑻ຓᩍ࡜ⓙᕝ⣧ᩍᤵࡣࠊ⥳⸴ࡀගྜᡂࡢチᐜ㔞ࢆୖᅇࡿ㐣๫࡞ග࢚ࢿࣝࢠ࣮ࢆᏳ඲࡟ᾘཤࡍࡿࡓࡵ࡟ࠊ≉Ṧ࡞ࢱࣥࣃࢡ㉁㸦/+&65㸧ࢆ⤖ྜࡋࡓᕧ኱࡞ගྜᡂ
ࢱࣥࣃࢡ㉁㉸」ྜయࢆᙧᡂࡍࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋᮏ◊✲ࡣࠊ᳜≀ࡢ⣽⬊ෆ࡛ග࢚ࢿࣝࢠ࣮ࢆᾘཤࡍ
ࡿᐇయࢆึࡵ࡚ᤕࡽ࠼ࡓࡶࡢ࡛࠶ࡾࠊࡇࢀࡲ࡛୙᫂࡞㒊ศࡀከࡃṧࡉࢀ࡚࠸ࡓග࢚ࢿࣝࢠ࣮ᾘཤࡢ௙⤌ࡳࡢ᏶඲⌮ゎࡀᮇᚅࡉࢀࡲࡍࠋࡇࡢ◊✲ᡂᯝࡣࠊ⡿ᅜ⛉Ꮫ࢔࢝ࢹ࣑࣮⣖せ㸦3URFHHGLQJVRIWKH1DWLRQDO
$FDGHP\RI6FLHQFHVRIWKH8QLWHG6WDWHVRI$PHULFD㸧ࡢ㟁Ꮚ㏿ሗ∧࡟⡿ᅜᮾ㒊᫬㛫㸳᭶㸰㸵᪥࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅࠊ :HE<$+22ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃

− 175 −

 ᖺ  ᭶  ᪥໬Ꮫ≀㉁ࡀ࣑ࢪࣥࢥࡢᛶࢆ࠿ࡃ஘ࡍࡿ௙⤌ࡳࢆゎ᫂
Miyakawa, H., Toyota, K., Hirakawa, I., Ogino, Y., Miyagawa, S., Oda, S.,
Tatarazako, N., Miura, T., Colbourne, J.K., and Iguchi, T. (2013). A mutation in
the Methoprene tolerant alters juvenile hormone response in insects andcrustaceans. Nature Commun. 4, 1856.
࣑ࢪࣥࢥࡢ௰㛫ࡣ⮬↛⏺࡛ࡣỈ࡞࡝ࡢ࿘ᅖࡢ⎔ቃ᮲௳࡟ࡼࡗ࡚Ꮚ࡝ࡶࡀ࢜ࢫ࡟࡞ࡿ࠿࣓ࢫ࡟࡞ࡿ࠿ࡀ

Ỵࡲࡾࡲࡍࠋࡋ࠿ࡋࠊẅ⹸๣࡞࡝࡟ྵࡲࢀ࡚࠸ࡿேᕤⓗ࡞໬Ꮫ≀㉁ࡀ࣑ࢪࣥࢥ࡟స⏝ࡍࡿ࡜ࠊ⎔ቃ࡜↓㛵ಀ࡟࢜ࢫࡋ࠿⏘ࡲࢀ࡚ࡇ࡞ࡃ࡞ࡗ࡚ࡋࡲ࠸ࡲࡍࠋࡇࡢ໬Ꮫ≀㉁ࡀ࣑ࢪࣥࢥࡢᛶࢆ࠿ࡃ஘ࡍࡿ࣓࢝ࢽࢬ
࣒ࡣ௒ࡲ࡛ࢃ࠿ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ௒ᅇࠊᒸᓮ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮࣭ᇶ♏⏕≀Ꮫ◊✲ᡤศᏊ⎔ቃ⏕≀Ꮫ◊✲㒊㛛ࡢᐑᕝ୍ᚿ◊✲ဨࠊ஭ཱྀὈἨᩍᤵࡢ◊✲ࢢ࣮ࣝࣉࡣࠊᅜ❧⎔ቃ◊✲ᡤࠊ໭ᾏ㐨኱Ꮫࠊࣂ࣮࣑࣒ࣥ࢞኱Ꮫ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ࣑ࢪࣥࢥࡢ௰㛫࡟࠾࠸࡚ࡇࢀࡽࡢ໬Ꮫ≀㉁ࢆཷࡅྲྀࡿࠕཷᐜయࠖࢆⓎぢࡋࠊẅ⹸๣࡟ྵࡲࢀࡿ໬Ꮫ≀㉁ࡀ⣽⬊ෆ࡛స⏝ࡍࡿලయⓗ࡞௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ
ࡇࡢ◊✲ᡂᯝࡣ⛉Ꮫ㞧ㄅ 1DWXUH&RPPXQLFDWLRQV ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ẖ᪥᪂⪺ 㠃ࠊ ᮾᾏឡ▱᪂⪺ 㠃ࠊ :HE࣐࢖ࢼࣅࠊ :HE<$+22ࠊ ᐑᓮ᪥᪥᪂⪺♫ࠊ ୰᪥᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺ 㠃 ᖺ  ᭶  ᪥㸦᪥㸧୰᪥᪂⪺ 㠃

− 176 −

 ᖺ  ᭶  ᪥᪂ୡ⏺ࢨࣝࡢ࣐࣮ࣔࢭࢵࢺࡢ኱⬻⓶㉁࡛ࡢ║ඃ఩ᛶ࣒࢝ࣛࡢᏑᅾࢆ☜ㄆ
Nakagami, Y., Watakabe, A., and Yamamori, T. (2013). Monocular inhibition
reveals temporal and spatial changes in gene expression in the primary visualcortex of marmoset. Front. Neural Circuits. 7, 43.⚾㐩ࣄࢺࡣྑ║࡜ᕥ║ࡢ஧ࡘࡢ║ࢆ౑ࡗ࡚ࠊ❧యど࡞࡝ࡢ㧗ᗘ࡞どぬࢆᐇ⌧ࡋ࡚࠸ࡲࡍࠋྑ║࡜ᕥ║࠿ࡽධຊࡉࢀࡓ᝟ሗࡣࠊ኱⬻ࡢ㸯ḟどぬ㔝࡟㏦ࡽࢀࡲࡍࡀࠊྑ║࠿ࡽࡢ᝟ሗ࡜ᕥ║࠿ࡽࡢ᝟ሗࡣࡑࢀࡒࢀ
㞄᥋ࡍࡿ㡿ᇦ࡟ධຊࡉࢀࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊࡇࡢ୍ḟどぬ㔝࡟࠾ࡅࡿᵓ㐀ࡣࠕ║ඃ఩ᛶ࣒࢝ࣛࠖ࡜
࿧ࡤࢀ࡚࠸ࡲࡍࠋࡇࡢ║ඃ఩ᛶ࣒࢝ࣛࡣࠊࣄࢺࡢ௚ࠊ㢮ே⊷ࡸ࣐࢝ࢡࢨࣝࠊࢿࢥ࡞࡝ࡢ⬻࡟Ꮡᅾࡍࡿࡇ
࡜ࡀࢃ࠿ࡗ࡚࠸ࡲࡍࠋ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤ⬻⏕≀Ꮫ◊✲㒊㛛ࡢ௰⚄཭㈗࡜ᒣ᳃ဴ㞝ᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ᪂ࡓ࡞ࣔࢹࣝ⏕≀࡜ࡋ࡚ὀ┠ࡉࢀ࡚࠸ࡿ᪂ୡ⏺ࢨࣝ࡟ᒓࡍࡿᑠᆺࡢࢧࣝࠊ࣐࣮ࣔࢭࢵࢺࡢ኱⬻⓶㉁࡟ࡶࠊ║ඃ఩ᛶ࣒࢝ࣛࡀᏑᅾࡍࡿࡇ࡜ࡢ☜ドࢆᚓࡲࡋࡓࠋࡇࢀࡣࠊどぬ᝟ሗฎ⌮◊✲࡟࠾ࡅࡿ᪂
ୡ⏺ࢨ࣭࣐࣮ࣝࣔࢭࢵࢺࡢ㟋㛗㢮࡜ࡋ࡚ࡢ≉㉁࡜᭷⏝ᛶࢆ♧ࡍᡂᯝ࡛ࡍࠋࡇࡢᡂᯝࡣ㸰㸮㸯㸱ᖺ㸲᭶㸷᪥࡟⬻⛉Ꮫᑓ㛛ㄅ )URQWLHUVLQ1HXUDO&LUFXLWV ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅࠊ :HE<$+22ࠊ ⛉Ꮫ᪂⪺㸰㠃  ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃− 177 −

 ᖺ  ᭶  ᪥⤌⧊㛫࡛ࡢ᝟ሗఏ㐩ࢆ௓ࡋࡓⴥࡢᡂ㛗࣓࢝ࢽࢬ࣒ࢆゎ᫂ࠥ㎰స≀ࡢ཰㔞ቑ⏘࡞࡝ᛂ⏝ศ㔝࡟ᮇᚅࠥ

Kawade, K., Horiguchi, G., Usami, T., Hirai, M.Y., and Tsukaya, H. (2013).
ANGUSTIFOLIA3 signaling coordinates proliferation between clonally distinct
cells in leaves. Current Biology 23, 788-792.
 ⌮໬Ꮫ◊✲ᡤࠊᮾி኱Ꮫࠊ❧ᩍ኱Ꮫ࡜ᇶ♏⏕≀Ꮫ◊✲ᡤࡣࠊࣔࢹ᳜ࣝ≀ࢩࣟ࢖ࢾࢼࢬࢼࢆ⏝࠸ࡓศᏊ㑇ఏᏛⓗ࡞ゎᯒ࠿ࡽࠊ᳜≀ࡢⴥ࡛ࡣ⾲⓶࡜ෆ㒊ࡢ⤌⧊࡟࠶ࡿ⣽⬊ࡀࠕ$1*867,)2/,$㸦$1㸧ࢱࣥࣃࢡ㉁ࠖ
ࢆ௓ࡋ࡚༠ㄪⓗ࡟ቑṪࡋ࡚࠸ࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋ$1 ࢱࣥࣃࢡ㉁࡟⺯ගࢱࣥࣃࢡ㉁ *)3ͤ ࢆ⼥ྜࡉࡏ࡚ほᐹࡋࡓ࡜ࡇࢁࠊⴥࡢෆ㒊⤌⧊࡛సࡽࢀࡓ $1 ࢱࣥࣃࢡ㉁ࡣ⤌⧊ࡢ㛫ࢆ⛣ືࡋࠊ⾲⓶ࡢ⣽⬊ቑṪࡶಁࡋ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡉࡽ࡟ࠊ$1 ࢱࣥࣃࢡ㉁ࢆ௓ࡋࡓ᝟ሗఏ㐩ࡀ᩿ࡓࢀࡿ࡜⾲⓶ࡢ⣽⬊ࡣ༑ศ࡟ቑ࠼ࡎࠊ⤖ᯝⓗ࡟ṇᖖ࡞ⴥࡢ  ๭⛬ᗘࡢ኱ࡁࡉ࡟ࡋ࠿ᡂ㛗࡛ࡁࡲࡏࢇ࡛ࡋࡓࠋ௒ᚋࠊࡇࡢ᝟
ሗఏ㐩ࢆ᧯సࡍࡿࡇ࡜࡛ࠊ㎰స≀ࡢቑ⏘࡞࡝ࡶྍ⬟࡟࡞ࡿ࡜ᮇᚅ࡛ࡁࡲࡍࠋᮏᡂᯝࡣࠊ⡿ᅜ⛉Ꮫ㞧ㄅ
ࠗ&XUUHQW%LRORJ\࠘㸦 ᭶  ᪥ྕ㸧࡬ࡢᥖ㍕࡟ඛ❧ࡕࠊ࢜ࣥࣛ࢖ࣥ∧㸦 ᭶  ᪥௜ࡅ㸸᪥ᮏ᫬㛫  ᭶ ᪥㸧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
− 178 −

 ᖺ  ᭶  ᪥
యᾮ 1D ⃰ᗘࢭࣥࢧ࣮ࡢㄪ⠇ᶵᵓࡢゎ᫂ࠥ⬻ෆ࢚ࣥࢻࢭࣜࣥ ࡢᙺ๭ࡀ᫂ࡽ࠿࡟ࠥ

+L\DPD7<<RVKLGD00DWVXPRWR06X]XNL50DWVXGD7:DWDQDEH( DQG 1RGD 0   (QGRWKHOLQ H[SUHVVLRQ LQ WKH VXEIRUQLFDO RUJDQHQKDQFHVWKHVHQVLWLYLW\RI1D[WKHEUDLQVRGLXPOHYHOVHQVRUWRVXSSUHVVVDOWLQWDNH&HOO0HWDE ◊✲ࢢ࣮ࣝࣉࡢࡇࢀࡲ࡛ࡢ◊✲࠿ࡽ 1D[ ࡀ୰ᯡࡢ 1D⃰ᗘࢭࣥࢧ࣮࡛࠶ࡿ࡜᥎ᐃࡉࢀࡲࡋࡓࡀࠊ኱ࡁ࡞
ㅦࡀṧࡉࢀ࡚࠸ࡲࡋࡓࠋࡑࢀࡣ 1D[ ࡀయእ࡛ࡣ 1D⃰ᗘࡀ⣙ P0 ࢆ㉸࠼࡚ึࡵ࡚άᛶ໬ࡍࡿ࡜࠸࠺ᛶ㉁ࢆ♧ࡋࡓࡇ࡜࡛ࡋࡓࠋయᾮࡢ 1D⃰ᗘࡣ㏻ᖖࠊ㹼P0 ࡟ཝᐦ࡟⥔ᣢࡉࢀ࡚࠸ࡲࡍࠋ1D[ ࡀ┿࡟⬻
ࡢ 1D⃰ᗘࢭࣥࢧ࣮࡛࠶ࡿ࡜ࡍࢀࡤ⏕⌮ⓗ⠊ᅖࡢ 1D⃰ᗘኚ໬ࢆឤ▱࡛ࡁࡿࡣࡎ࡛ࡍࠋ௒ᅇࠊ◊✲ࢢ࣮ࣝࣉࡣࠊࡇࡢṧࡉࢀ࡚࠸ࡓㄢ㢟ࢆゎỴࡍࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋ1D[ ࡢάᛶ໬㜈್ࡣయෆ࡛ࡣ⏕⌮ⓗ⠊ᅖࡢ1D⃰ᗘࡢୖ᪼࡟ᛂ⟅࡛ࡁࡿࡼ࠺࡟࡞ࡗ࡚࠸ࡲࡋࡓࠋࡑࢀࡣᅛᐃࡉࢀࡓࡶࡢ࡛ࡣ࡞ࡃࠊ⬺Ỉ≧ែ࡟ᛂࡌ࡚
ㄪ⠇ࡉࢀࡿࡇ࡜ࡶุࡾࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣࠊ ᖺ  ᭶  ᪥࡟⡿ᅜ⛉Ꮫᑓ㛛ㄅ &HOO0HWDEROLVP ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸  ⛉Ꮫ᪂⪺  㠃 ᖺ  ᭶  ᪥㸦㔠㸧⛉Ꮫ᪂⪺ 㠃
− 179 −

 ᖺ  ᭶  ᪥࣓ࢲ࢝ࡢ࢘ࣟࢥࡀドࡍ㦵ࡢ㉳※

Shimada, A., Kawanishi, T., Kaneko, T., Yoshihara, H., Yano, T., Inohaya, K.,
Kinoshita, M., Kamei, Y., Tamura, K., and Takeda, H. (2013). Trunk
exoskeleton in teleosts is mesodermal in origin. Nature Commun. 4, 1639.
㨶ࡢ࢘ࣟࢥࡸࣄࣞࡀⓎ⏕୰ࡢ⬇ࡢ࡝ࡢ⣽⬊࠿ࡽసࡽࢀࡿ࠿ࡣࠊ⬨᳝ື≀ࡢ㦵ࡢ㉳※ࡸ㐍໬ࢆゎࡃ㘽࡜࡞ࡿၥ㢟࡛࠶ࡿ࡟ࡶ࠿࠿ࢃࡽࡎࠊ㛗ᖺㅦ࡟ࡘࡘࡲࢀࡓࡲࡲࡔࡗࡓࠋ⣽⬊ࡢ㐠࿨ࡣ⬇Ⓨ⏕ึᮇ࡟ࡲࡎእ⬇ⴥࠊෆ⬇ⴥࠊ୰⬇ⴥ࡟ศ࠿ࢀࠊࡑࡢᚋࡑࢀࡒࢀࠊ⚄⤒⣔ࡸෆ⮚ࠊ㦵࡞࡝࡟㡰ḟศ໬ࡋ࡚⾜ࡃࠋࡉࡽ࡟⬨᳝ື≀࡟ࡣ➨ᅄࡢ⬇ⴥ࡜ࡶ࿧ࡤࢀࡿ≉ู࡞⣽⬊ࠊ⚄⤒ሐࡀ࠶ࡿࠋ㏻ᖖࠊࡇࢀࡽࡢ⬇ⴥࢆ㉸࠼࡚⤌⧊ࢆศ໬ࡉ
ࡏࡿࡇ࡜ࡣ㞴ࡋ࠸ࡓࡵࠊ⣽⬊ࡢ⏤᮶㸦⣔㆕㸧᝟ሗࡣ㠀ᖖ࡟㔜せ࡛࠶ࡿࠋᮾி኱Ꮫ኱Ꮫ㝔⌮Ꮫ⣔◊✲⛉ᓥ⏣ᩔᏊຓᩍ࣭Ṋ⏣ὒᖾᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊᇶ♏⏕≀Ꮫ◊✲ᡤட஭ಖ༤≉௵෸ᩍᤵࡽ࡜ඹྠ࡛ࠊୡ
⏺࡛ึࡵ࡚ᡂ㨶ࡲ࡛㦵ࡢ⣽⬊⣔㆕ࢆࡓ࡝ࡿᐇ㦂⣔ࡢ㛤Ⓨ࡟ᡂຌࡋࠊ࢘ࣟࢥࡸࣄࣞࡀᚑ᮶ࡢㄝ࡛⪃࠼ࡽࢀ࡚࠸ࡓ⚄⤒ሐ⣽⬊⏤᮶࡛ࡣ࡞ࡃࠊ୰⬇ⴥ⣽⬊⏤᮶࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋࡇࢀ࡟ࡼࡗ࡚⬨᳝ື≀ࡣண᝿እ࡟ࠕᰂ㌾ࠖ࡞᪉ἲ࡛㦵ࢆ㐍໬ࡉࡏ࡚ࡁࡓࡇ࡜ࡀࢃ࠿ࡗࡓࠋᮏ◊✲ࡣ㦵ࡢⓎ⏕ᶵᵓࡸ෌⏕་⒪࡟㛵ࡍࡿ௒ᚋࡢ◊✲࡟࠾࠸࡚㐨ࡋࡿ࡭࡜ࡶ࡞ࡿᡂᯝ࡛࠶ࡾࠊศ໬ㄏᑟ࡟㛵ࢃࡿ㑇ఏᏊࡢ᥈⣴ࢆࡼࡾṇ☜࡟⾜࠺ࡓࡵࡢ᝟ሗ࡜࡞ࡿ࡜ᛮࢃࢀࡿࠋ
− 180 −

 ᖺ  ᭶  ᪥⥳⸴ࡣ஧㔜ࡢᙉග㥆໬࡟ࡼࡾගྜᡂჾᐁࢆࡲࡶࡗ࡚࠸ࡿ

Allorent*,* Tokutsu*, R., Roach, T., Peers, G., Cardol, P., Girard-Bascoui, J.,
Seigneurin-Berny, D., Petroutsos, D., Kuntz, M., Breyton, C., Franck, F.,
Wollman, F., Niyogi, K.K., Krieger-Liszkay, A., Minagawa, J., and Finazzi, G.
(2013). A dual strategy to cope with high light in Chlamydomonas reinhardtii.
Plant Cell 25, 545-557. (*These authors contributed equally to this work.)ᇶ♏⏕≀Ꮫ◊✲ᡤ⎔ቃග⏕≀Ꮫ◊✲㒊㛛㸦ᚓὠ㝯ኴ㑻ຓᩍ㸪ⓙᕝ⣧ᩍᤵ㸧࡜ࣇࣛࣥࢫཎᏊຊᗇ⏕≀⛉Ꮫᢏ⾡◊✲ᡤ㸦ࢠ࣮࣒࣭ࣚ࢔ࣟࣛࣥ◊✲ဨ㸪ࢪࣙࣂࣥࢽ࣭ࣇ࢕ࢼࢵࢳ◊✲㒊㛗㸧࡞࡝ࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ
ගྜᡂ⥳⸴ࡀᙉࡍࡂࡿග࡟ࡼࡿࢫࢺࣞࢫୗ࡛⏕ࡁṧࡿࡓࡵ࡟ࠊ㸰ࡘࡢ␗࡞ࡿග㐺ᛂ཯ᛂࢆᕦࡳ࡟⤌ࡳྜࢃࡏ࡚ᑐᛂࡋ࡚࠸ࡿࡇ࡜ࢆぢ࠸ࡔࡋࡲࡋࡓࠋᮏ◊✲ࡣࠊ᳜≀ࡢᙉග㐺ᛂࡢ௙⤌ࡳࡢᐇែࢆึࡵ࡚᫂ࡽ࠿
࡟ࡋࡓࡶࡢ࡛࠶ࡾࠊࡇࢀࢆࡶ࡜࡟ᙉගࢫࢺࣞࢫ࡟ᙅ࠸ගྜᡂ⏕≀ࡢ᢬ᢠᛶࢆᙉ໬㸦᭱㐺໬㸧ࡋࠊ◁₍࡞࡝ࡢ㐣㓞࡞ሙᡤ࡛ࡶ⫱ᡂྍ⬟࡞㎰స≀ࡸࣂ࢖࢜⇞ᩱ⸴㢮ࡢ๰ᡂ࡬ࡢ㊊ࡀ࠿ࡾ࡟࡞ࡿࡇ࡜ࡀᮇᚅࡉࢀࡲࡍࠋ
ࡇࡢ◊✲ᡂᯝࡣࠊ᳜≀⛉Ꮫᑓ㛛ㄅ 7KH3ODQW&HOO ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ ⛉Ꮫ᪂⪺  㠃

− 181 −

 ᖺ  ᭶  ᪥ ᖺ᮶ࡢㅦࠊ㝣ୖ᳜≀ࡢୡ௦஺௦ࢆไᚚࡍࡿᅉᏊࡢⓎぢ
Sakakibara, K., Ando, S., Yip, H.K., Tamada, Y., Hiwatashi, Y., Murata, T.,
Deguchi, H., Hasebe, M., and Bowman, J.L. (2013). KNOX2 genes regulate thehaploid-to-diploid morphological transition in land plants. Science 339,
1067-1070.
⏕≀࡟ࡣᰁⰍయࡢࢭࢵࢺࢆ㸯⤌ᣢࡗ࡚࠸ࡿ᫬ᮇ㸦༢┦㸧࡜㸰⤌ᣢࡗ࡚࠸ࡿ᫬ᮇ㸦」┦㸧ࡀ࠶ࡾࡲࡍࠋࢃ
ࡓࡋࡓࡕே㛫ࡢయࡣ」┦࡟࠶ࡓࡾࡲࡍࠋ༢┦࡟┦ᙜࡍࡿࡢࡣ༸ࡸ⢭Ꮚ࡜࠸ࡗࡓ༢⣽⬊࡛ࠊ࠸ࡎࢀࡶ༢⊂࡛ࡣ⏕ά࡛ࡁࡲࡏࢇࠋ୍᪉ࠊࢻ࢖ࢶࡢ࣍ࣇ࣐࢖ࢫࢱ࣮ࡣ  ᖺ௨ୖ๓࡟㝣ୖ᳜≀ࡣᙧࡶ≉ᚩࡶ␗࡞ࡿከ
⣽⬊ࡢయࢆ஺஫࡟సࡿࡇ࡜ࢆⓎぢࡋࠊࡑࢀࢆୡ௦஺௦࡜ྡ௜ࡅࡲࡋࡓࠋࡑࡢᚋࠊ㝣ୖ᳜≀ࡣ༢┦࡜」┦ࡢࡑࢀࡒࢀᙧែࡢ␗࡞ࡿ㓄അయ࡜⬊Ꮚయࢆసࡾࠊࡑࢀࢆ஺஫࡟⧞ࡾ㏉ࡍୡ௦஺௦࡜ࡋ࡚▱ࡽࢀࡿࡼ࠺࡟
࡞ࡾࡲࡋࡓࠋࡑࢀࡒࢀࡢᙧసࡾࡢࣉࣟࢢ࣒ࣛࡣཝᐦ࡟ไᚚࡉࢀ࡚࠾ࡾࠊษ᥮࠼࡟ാࡃࢫ࢖ࢵࢳࡀᏑᅾࡍ
ࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡲࡋࡓࠋ௒ᅇࠊᗈᓥ኱Ꮫ኱Ꮫ㝔⌮Ꮫ◊✲⛉ࡢᴬཎᜨᏊ≉௵ຓᩍࠊฟཱྀ༤๎ᩍᤵࡽࡣ࢜
࣮ࢫࢺࣛࣜ࢔࣭ࣔࢼࢩࣗ኱Ꮫࡢ -RKQ%RZPDQ ᩍᤵࠊᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㛗㇂㒊ගὈᩍᤵࡽ࡜ࡢඹྠ◊✲࡟ࡼࡾࠊࢥࢣ᳜≀ࣄ࣓ࢶࣜ࢞ࢿࢦࢣࢆ౑ࡗ࡚༢┦࠿ࡽ」┦࡬ࡢษ᥮࠼࡟ࢫ࢖ࢵࢳ࡜ࡋ࡚ാࡃ㑇ఏᏊࢆⓎぢࡋࡲࡋࡓࠋࡇࡢ㑇ఏᏊࢆḞኻࡉࡏࡿ࡜ࠊ」┦ࡢ᫬ᮇ࡟㛫㐪ࡗ࡚༢┦ࡢయࢆసࡗ࡚ࡋࡲ࠸ࡲࡍࠋ⌧ᅾࠊᆅ⌫ୖ࡛᭱ࡶ⦾ᰤࡋ࡚࠸ࡿ㝣ୖ᳜≀ࡣⰼࢆဏ࠿ࡏࡿ⿕Ꮚ᳜≀࡛ࡍࡀࠊࡑࡢయࡢ኱༙ࡣ」┦࡛ࡍࡢ࡛ࠊࡇ
ࡢࢫ࢖ࢵࢳࡀ࠺ࡲࡃാࡃࡇ࡜ࡣ᳜≀࡟ྲྀࡗ࡚࡜࡚ࡶ኱ษ࡛ࡍࠋࡇࡢᡂᯝࡣࠊ⛉Ꮫ㞧ㄅ 6FLHQFH ࡟ ᭶ ᪥࡟Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE୰ᅜ᪂⪺ࠊ ᪥ᮏ⤒῭᪂⪺  㠃ࠊ ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ ᮅ᪥᪂⪺  㠃− 182 −

 ᖺ  ᭶  ᪥࣐࢘ࢫึᮇ⬇࡟࠾ࡅࡿࢲ࢖ࢼ࣑ࢵࢡ࠿ࡘᕥྑ㠀ᑐ⛠࡞࢝ࣝࢩ࣒࢘ࢩࢢࢼࣝࢆⓎぢ㹼ᕥྑ㠀ᑐ⛠Ỵᐃࡢ࣓࢝ࢽࢬ࣒ゎ᫂࡬ࡢᡭࡀ࠿ࡾ࡟㹼Takao, D., Nemoto, T., Abe, T., Kiyonari, H., Kajiura-Kobayashi, H., Shiratori,
H., and Nonaka, S. (2013). Asymmetric distribution of dynamic calcium signals
in the node of mouse embryo during left-right axis formation. Develop. Biol. 376,
23-30.
 ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㔝୰ⱱ⣖෸ᩍᤵ࡜㧗ᑿ኱㍜◊✲ဨࡽࡣࠊ໭ᾏ㐨኱Ꮫ㟁Ꮚ⛉Ꮫ◊✲ᡤࠊ⌮໬Ꮫ◊✲ᡤࠊ኱㜰኱Ꮫ኱Ꮫ㝔࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ࣐࢘ࢫⓎ⏕ࡢᕥྑ㠀ᑐ⛠Ỵᐃ࡟㛵ࢃࡿࡇ࡜ࡀ♧၀ࡉࢀࡿ࢝ࣝ
ࢩ࣒࢘ࢩࢢࢼࣝࢆⓎぢࡋࡲࡋࡓࠋ ࣐࢘ࢫⓎ⏕࡟࠾࠸࡚ᕥྑࡀ᭱ึ࡟Ỵࡲࡿࡢࡣࠊ⬇⾲㠃ࡢࣀ࣮ࢻ࡜࿧ࡤࢀࡿ㒊఩࡛ࡍࠋ࠿ࡘࠊࡇࡢ㒊఩࡟࠾ࡅࡿ⣽⬊ෆ࢝ࣝࢩ࣒࢘ࡀ㔜せ࡛࠶ࡿࡇ࡜ࡀศ࠿ࡗ࡚࠸ࡲࡍࠋࡋ࠿ࡋࠊ⫢ᚰࡢࣀ࣮ࢻ⣽⬊ࡢ࢝ࣝࢩ࢘
࣒ືែࡣศ࠿ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ ᮏ◊✲࡛ࡣࠊࣀ࣮ࢻࢆᵓᡂࡍࡿᩘⓒࡢ⣽⬊ࡀࢲ࢖ࢼ࣑ࢵࢡ࡟࢝ࣝࢩ࣒࢘⃰ᗘࡢୖ᪼ୗ㝆ࢆ⧞ࡾ㏉ࡍࡇ࡜ࢆ᪂ࡓ࡟Ⓨぢࡋࡲࡋࡓࠋࡇࢀࢆヲ⣽࡟ゎᯒࡍࡿࡇ࡜࡟ࡼࡾࠊᑗ᮶ࡢᕥྑࡀỴᐃࡉࢀࡿ᫬ᮇ࡟ࠊ᭱ึࡣ
ᕥྑᕪࡢ࡞࠿ࡗࡓ࢝ࣝࢩ࣒࢘ୖ᪼ࡢ㢖ᗘࡀࠊᕥഃ࡛ࡼࡾ㧗ࡃ࡞ࡿࡇ࡜ࢆ✺ࡁ࡜ࡵࡲࡋࡓࠋࡑࡋ࡚ࡇࡢ࢝
ࣝࢩ࣒࢘ࢩࢢࢼࣝࡣయࡢᕥྑᛶỴᐃ࡟㛵ࢃࡗ࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀࡲࡋࡓࠋࡇࡢ▱ぢࡣࠊ⚾ࡓࡕࡢయࡢ
ᕥྑ㠀ᑐ⛠ࡀ࡝ࡢࡼ࠺࡟⏕ࡳฟࡉࢀ࡚࠸ࡿࡢ࠿ࢆ▱ࡿࡓࡵࡢ㔜せ࡞ᡭࡀ࠿ࡾ࡛ࡍࠋᮏ◊✲ࡣ⡿Ⓨ⏕⏕≀
Ꮫ఍ㄅࠕ'HYHORSPHQWDO%LRORJ\ࠖ㟁Ꮚ∧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅ

− 183 −

 ᖺ  ᭶  ᪥࣮࢜ࢺࣇ࢓ࢪ࣮ࡀᰁⰍయࢆᏳᐃ໬ࡍࡿࡋࡃࡳࡢゎ᫂ ࠥᰤ㣴Ḟஈ᮲௳ୗ࡛ࡢ⣽⬊ศ⿣࡟ࡣࢱࣥࣃࢡ㉁ࡢศゎ࡜෌฼⏝ࡀ㔜せࠥMatsui, A., Kamada, Y., and Matsuura, A. (2013). The role of autophagy ingenome stability through suppression of abnormal mitosis under starvation.
PLOS Genetics 9, e1003245.
 ༓ⴥ኱Ꮫ኱Ꮫ㝔⼥ྜ⛉Ꮫ◊✲⛉ࡢᯇᾆᙲᩍᤵࠊᯇ஭ឡᏊ᪥ᮏᏛ⾡᣺⯆఍≉ู◊✲ဨ㸦༤ኈᚋᮇㄢ⛬㸧ࠊ⮬↛⛉Ꮫ◊✲ᶵᵓᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㙊⏣ⰾᙲຓᩍࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ⣽⬊ࡢࣜࢧ࢖ࢡࣝࢩࢫࢸ࣒࡛࠶
ࡿ࣮࢜ࢺࣇ࢓ࢪ࣮ࡀࠊᰤ㣴ࡀḞஈࡋࡓ⎔ቃୗ࡛⣽⬊ศ⿣ࢆ᏶஢ࡍࡿࡓࡵ࡟㔜せ࡛࠶ࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋ࣮࢜ࢺࣇ࢓ࢪ࣮ࢆ⾜࠼࡞࠸⣽⬊࡛ࡣࠊᰤ㣴Ḟஈ⎔ቃୗ࡛ṇᖖ࡞ศ⿣ࡀ࡛ࡁࡎࠊࡑࡢ⤖ᯝᰁⰍయᩘࡢ
␗ᖖࡀ⏕ࡌࡸࡍࡃ࡞ࡿࡇ࡜࠿ࡽࠊ࣮࢜ࢺࣇ࢓ࢪ࣮࡟ࡣ⒴࡞࡝ࡢཎᅉ࡜࡞ࡿᰁⰍయ␗ᖖࢆᢚไࡍࡿാࡁࡀ
࠶ࡿ࡜⪃࠼ࡽࢀࡲࡍࠋࡇࡢ◊✲ᡂᯝࡣ⡿ᅜ⛉Ꮫ㞧ㄅࠕ3/26*HQHWLFVࠖ࢜ࣥࣛ࢖ࣥ∧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅ



− 184 −

 ᖺ  ᭶  ᪥㐨ලࢆ౑ࡗࡓ㝶ព㐠ື୰ࡢ኱⬻⚄⤒⣽⬊ࡢάືࣃࢱ࣮ࣥࡀ᫂ࡽ࠿࡟ ࠥ⚄⤒άືࣃࢱ࣮ࣥ࠿ࡽࡢ⾜ືண ࡟ࡶᡂຌࠥ

+LUD 5 2KNXER ) 2]DZD . ,VRPXUD < .LWDPXUD . .DQR 0 .DVDL + DQG0DWVX]DNL 0   6SDWLRWHPSRUDO G\QDPLFV RI IXQFWLRQDO FOXVWHUV RI QHXURQV LQ WKHPRXVHPRWRUFRUWH[GXULQJDYROXQWDU\PRYHPHQW-1HXURVFL
ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᯇᓮᨻ⣖ᩍᤵ࡜ᖹ⌮୍㑻኱Ꮫ㝔⏕ࡢ◊✲ࢢ࣮ࣝࣉࡣࠊᮾி኱Ꮫ኱Ꮫ㝔་Ꮫ⣔◊✲⛉㸦Ἑす᫓㑻ᩍᤵࠊ⊁㔝᪉ఙᩍᤵࠊ႐ከᮧ࿴㑻෸ᩍᤵ㸧ࠊ⋢ᕝ኱Ꮫ⬻⛉Ꮫ◊✲ᡤ㸦♒ᮧᐅ࿴ᩍᤵ㸧࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ࣐࢘ࢫࡀ㐨ලࢆ౑࠺㐠ືࢆ⾜࠺㝿ࡢࠊ኱⬻⓶㉁㐠ື㔝ࡢᩘ༑ಶࡢ⚄⤒⣽⬊ࡢάືࢆྠ᫬࡟
ィࡍࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ⾜ື࡟㛵ࢃࡿᖹᆒ㸶ಶࡢ⚄⤒⣽⬊࠿ࡽᡂࡿᚤᑠ࡞⚄⤒ࢿࢵࢺ࣮࣡ࢡࢆぢ࠸ࡔࡋࠊࡇࡢ⚄⤒⣽⬊㞟ᅋࡢάືࡢࣃࢱ࣮ࣥ࠿ࡽࠊ࣐࢘ࢫࡀ⾜ືࢆ㉳ࡇࡍࢱ࢖࣑ࣥࢢࡢண
࡟ࡶᡂຌࡋࡲࡋࡓࠋᮏ◊✲ࡣࠊ⦎⩦ࢆ⧞ࡾ㏉ࡍ࡜࡝࠺ࡋ࡚⚾ࡓࡕࡣ㐠ືࡀ࠺ࡲࡃ࡞ࡿࡢ࠿࡜࠸࠺㐠ືᏛ⩦ࡢ࣓࢝ࢽࢬ࣒ࡸࠊࣃ࣮࢟ࣥࢯࣥ⑓࡞࡝ࡢ⚄⤒࣭⢭⚄⑌ᝈ࡛ࡢ኱⬻⚄⤒⣽⬊άືࡢ␗ᖖᶵᵓࢆ᫂ࡽ࠿࡟
ࡍࡿࡓࡵࡢ㔜せ࡞୍Ṍ࡛ࡍࠋࡇࡢᡂᯝࡣࠊ໭⡿⚄⤒⛉Ꮫ఍ㄅࠕ7KH-RXUQDORI1HXURVFLHQFHࠖ㸰㸮㸯㸱ᖺ㸯᭶㸰㸱᪥ྕ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ᮾዟ᪥ሗ  㠃ࠊ :HE࣐࢖ࢼࣅࠊ :HEඹྠ㏻ಙ♫ࠊ ᪥⤒⏘ᴗ᪂⪺ 㠃ࠊ ⛉Ꮫ᪂⪺  㠃

− 185 −

 ᖺ  ᭶  ᪥᪂ୡ⏺ࢨࣝࡢ┠ࡢ୰࡟࣮ࣔࢩ࣭ࣙࣥࢹ࢕ࢸࢡࢱ࣮࡜⪃࠼ࡽࢀࡿど⚄⤒⣽⬊ࢆⓎぢ̿㟋㛗㢮⥙⭷▷ᮇᇵ㣴ಖᏑἲࡢ☜❧࠾ࡼࡧ㑇ఏᏊᑟධ࡛㸫
Moritoh, S., Komatsu, Y., Yamamori, T., and Koizumi, A. (2013). Diversity ofretinal ganglion cells identified by transient GFP transfection in organotypic
tissue culture of adult marmoset monkey retina. PLOS ONE 8, e54667.
⮬↛⛉Ꮫ◊✲ᶵᵓ⏕⌮Ꮫ◊✲ᡤࡢᑠἨ࿘෸ᩍᤵ࡞ࡽࡧ࡟᳃⸨ᬡ༤ኈ㸦⌧࣭ᮾ໭኱Ꮫ་Ꮫ㒊㸧࡜ᑠᯇຬ
௓≉௵ຓᩍ㸦ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭ࣔࢹࣝ⏕≀◊✲ࢭࣥࢱ࣮࣭࣐࣮ࣔࢭࢵࢺ◊✲᪋タ࣭◊✲ဨ㸧ࡢඹྠ◊✲ࢢ࣮ࣝࣉࡣࠊ᪂ୡ⏺ࢨࣝ㸦࣐࣮ࣔࢭࢵࢺ㸧࡜࿧ࡤࢀࡿࢧࣝࡢ┠ࡢ୰ࡢ⚄⤒⤌⧊࡛࠶ࡿ⥙⭷࡟ࡣࠊᵝࠎ
࡞ᙧࡢど⚄⤒⣽⬊㸦⥙⭷⚄⤒⠇⣽⬊㸧ࡀ࠶ࡾࠊ୰࡛ࡶࠊᙧែᏛⓗ࡟࣮ࣔࢩ࣭ࣙࣥࢹ࢕ࢸࢡࢱ࣮ࡢ≉ᚩࢆ඲࡚ࡶࡘど⚄⤒⣽⬊ࢆぢࡘࡅࡔࡋࡲࡋࡓࠋࡇ࠺ࡋࡓ࣮ࣔࢩ࣭ࣙࣥࢹ࢕ࢸࢡࢱ࣮࡜⪃࠼ࡽࢀࡿ⣽⬊ࡀࠊ㟋㛗㢮⥙⭷࡛Ⓨぢࡉࢀࡓࡢࡣࡣࡌࡵ࡚ࠋ⡿ᅜ⛉Ꮫㄅࣉࣟࢫ࣭࣡ࣥ㸦3/2621(ࠊ㸯᭶㸯㸳᪥㟁Ꮚ∧㸧࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡣࠊୡ⏺࡟ඛ㥑ࡅ࡚ࠊ᪂ୡ⏺ࢨࣝࡢ⥙⭷ࢆࠊࡲࡿࡈ࡜ྲྀࡾฟࡋࠊ▷ᮇᇵ㣴ಖᏑࡍࡿ᪉ἲࡢ☜❧࡟ᡂຌࡍࡿ࡜࡜ࡶ࡟ࠊಖᏑࡋࡓ⥙⭷࡬ࡢ⥳Ⰽ⺯ගࢱࣥࣃࢡ㉁㸦*)3㸧ࡢ㑇ఏᏊᑟධ࡟ࡼ
ࡗ࡚ࠊྂࡃ࠿ࡽ▱ࡽࢀ࡚࠸ࡿど⚄⤒⣽⬊௨እ࡟ࡶࠊከᵝ࡞ᙧែᏛⓗ≉ᚩࢆࡶࡗࡓど⚄⤒⣽⬊ࡀ✀ࠎ࠶ࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋ୰࡛ࡶࠊ࢘ࢧࢠࡸࢿࢬ࣑࡜࠸ࡗࡓୗ➼࡞့ங㢮⥙⭷࡛Ⓨぢࡉࢀ࡚࠸ࡿࡶࡢ࡜ྠᵝࡢᙧែᏛⓗ࡞≉ᚩࢆ඲࡚ࡶࡗࡓ࣮ࣔࢩ࣭ࣙࣥࢹ࢕ࢸࢡࢱ࣮࡜⪃࠼ࡽࢀࡿど⚄⤒⣽⬊㸦᪉ྥ㑅ᢥᛶ⥙⭷⚄⤒⠇⣽⬊㸧ࢆぢࡘࡅࡔࡋࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE ࣐࢖ࢼࣅ

− 186 −

 ᖺ  ᭶  ᪥᰿⢏࡜ⱼ㡬ศ⿣⤌⧊ࢆඹ㏻ࡋ࡚ไᚚࡍࡿ᪂ࡓ࡞㑇ఏᏊࡢⓎぢ
Suzaki, T., Kim, C.S., Takeda, N., Szczyglowski, K., and Kawaguchi, M. (2013). 75,&27
encodes an AMP1-related carboxypeptidase that regulates root nodule development andshoot apical meristem maintenance in /RWXVMDSRQLFXVDevelopment  ᇶ♏⏕≀Ꮫ◊✲ᡤඹ⏕ࢩࢫࢸ࣒◊✲㒊㛛ࡢᑑᓮᣅဢຓᩍ࡜ᕝཱྀṇ௦ྖᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ࣐࣓
⛉᳜≀࡜᰿⢏⳦ࡢඹ⏕ࡢሙ࡛࠶ࡿࠕ᰿⢏ࠖࡀࠊ᰿࠿ࡽศ໬ࡍࡿ㐣⛬ࢆไᚚࡍࡿ᪂ࡓ࡞㑇ఏᏊࢆⓎぢࡋࡲࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡀ 75,&27㸦ࢺࣜࢥ㸧࡜ྡ௜ࡅࡓࡇࡢ㑇ఏᏊࡣࠊ᰿⢏ᙧᡂ࡟࠾࠸࡚㔜せ࡞ᙺ๭ࢆᢸ࠺
ࡔࡅ࡛࡞ࡃࠊⴥࡸⱼ࡞࡝ᆅୖ㒊ࡢჾᐁࡢⓎ⏕ࢆྖࡿࠕⱼ㡬ศ⿣⤌⧊ࠖࡢάᛶ⥔ᣢ࡟ࡶ㛵୚ࡍࡿࡇ࡜ࡀࢃ
࠿ࡾࠊ᰿⢏࡜௚⤌⧊ࡢᙧ࡙ࡃࡾࡢඹ㏻ᛶࡸ᰿⢏ඹ⏕ࡢ㐍໬ᇶ┙ࡢ୍➃ࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣࠊ⏕≀Ꮫᑓ㛛ㄅ 'HYHORSPHQW ࡢ㟁Ꮚ㏿ሗ∧࡟㸯㸰᭶㸯㸶᪥࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ ᮏ◊✲࡟ࡼࡗ࡚≉ᐃࡉࢀࡓ 75,&27 㑇ఏᏊࡣࠊ᰿⢏࡜ⱼ㡬ศ⿣⤌⧊ࡢᙧᡂࢆඹ㏻ࡋ࡚ไᚚࡍࡿ㑇ఏᏊ࡛ࡍࠋ⚾ࡓࡕࡢ◊✲ࢢ࣮ࣝࣉࡣࡇࢀࡲ࡛࡟ࡶ ./$9,(5 ./9 ࡜ྡ௜ࡅࡓ㑇ఏᏊࡀࡇࡢඹ㏻ࡋࡓไᚚ࡟㛵ࢃࡿࡇ࡜ࢆሗ࿌ࡋ࡚࠸ࡲࡍࠋᆅ⌫ୖ࡟ࡣከ✀ከᵝ࡞᳜≀ࡀᏑᅾࡋ࡚࠸ࡲࡍࡀࠊࡑࡢ୰࡛ࡶࠊ࡝࠺ࡋ࡚୺࡟
࣐࣓⛉ࡔࡅࡀ᰿⢏ࢆࡘࡃࡿࡇ࡜ࡀ࡛ࡁࡿࡢ࠿ࠊࡑࡢ⌮⏤ࡣࡣࡗࡁࡾࢃ࠿ࡗ࡚࠸ࡲࡏࢇࠋࡋ࠿ࡋࠊ⚾ࡓࡕࡢ◊✲ᡂᯝ࠿ࡽࠊ᳜≀ࡢ㛗࠸㐍໬ࡢṔྐࡢ୰࡛ࠊ7&2 ࡸ ./9 ࡢࡼ࠺࡞ⱼ㡬ศ⿣⤌⧊ࡢไᚚ࡟㛵ࢃࡿ㑇ఏᏊࢆ᰿⢏ᙧᡂ࡟ὶ⏝ࡋࡓࡇ࡜ࡀࠊ࣐࣓⛉᳜≀ࡀ᰿⢏ࢆࡘࡃࡿ⬟ຊࢆ⋓ᚓࡍࡿ࡟⮳ࡗࡓ  ࡘࡢせᅉ࡟࡞ࡗࡓྍ⬟ᛶࡀ⪃࠼ࡽࢀࡲࡍࠋ௒ᚋࡢ◊✲ࡢ㐍ᒎ࡟ࡼࡾࠊ᰿⢏ᙧᡂ࡟㛵ࢃࡿ㑇ఏᏊࡢാࡁࢆㄪ࡭ࡿࡇ࡜࡟ࡼ
ࡗ࡚ࠊ᳜≀ࡢ㐍໬ࡢ㐣⛬࡛᰿⢏ඹ⏕ࡀ࡝ࡢࡼ࠺࡟ࡋ࡚ㄌ⏕ࡋࡓࡢ࠿ࡀゎ᫂ࡉࢀࡿࡇ࡜ࡀᮇᚅࡉࢀࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 :HE<$+22ࠊ :HEMLML ㏻ಙࠊ ⛉Ꮫ᪂⪺  㠃

− 187 −

 ᖺ  ᭶  ᪥ࢩࣙ࢘ࢪࣙ࢘ࣂ࢚༸ᕢࡢ⣽⬊࡟఩⨨᝟ሗࢆఏ࠼ࡿ࣓࢝ࢽࢬ࣒ࡢゎ᫂Hayashi, Y., Sexton, T.R., Dejima, K., Perry, D.W., Takemura, M., Kobayashi, S.,
Nakato, H., and Harrison, D.A. (2012). Glypicans regulate JAK/ STAT
signaling and distribution of the Unpaired morphogen. Development 139,4162-4171.
 ᒸᓮ⤫ྜࣂ࢖࢜ࢭࣥࢱ࣮㸭ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᯘⰋᶞຓᩍࠊᑠᯘᝅᩍᤵࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ࣑ࢿࢯࢱ
኱Ꮫ㸦୰⸨༤ᚿ෸ᩍᤵ㸧ࠊࢣࣥࢱࢵ࣮࢟኱Ꮫ㸦'RXJUDVV+DUULVRQ ෸ᩍᤵ㸧࡜ࡢඹྠ◊✲࡟ࡼࡾࠊ⣽⬊࠿ࡽ⣽⬊࡬᝟ሗࢆఏ㐩ࡍࡿศᏊ㸦ࢩࢢࢼࣝఏ㐩ᅉᏊ㸧ࡢ୍ࡘࠊ-$.67$7 ࢩࢢࢼࣝఏ㐩ᅉᏊࡀ⤌⧊ෆ࡛ศᕸࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ
 -$.67$7 ࢩࢢࢼࣝఏ㐩ᅉᏊࡣࠊ⣽⬊ࡀ⤌⧊୰࡛⮬㌟ࡢ఩⨨ࢆᢕᥱࡍࡿ㝿࡟౑࠺ศᏊ㸦ࣔࣝࣇ࢛ࢤࣥ
࡜ࡋ࡚ᶵ⬟ࡍࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡲࡋࡓࡀࠊ⤌⧊୰࡛ࡢศᕸࡸࡑࢀࢆไᚚࡍࡿ௙⤌ࡳࡣ୙࡛᫂ࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡣࠊࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࡢ༸ᕢࢆࣔࢹࣝ࡜ࡋ࡚⏝࠸ࡿࡇ࡜࡛ࠊ-$.67$7 ࢩࢢࢼࣝఏ㐩ᅉᏊࡢศᕸࡢほᐹࡍࡿࡇ࡜ࠊࡉࡽ࡟ศᕸࢆไᚚࡍࡿศᏊࢆ≉ᐃࡍࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋ◊✲ࡢ⤖ᯝࠊ-$.67$7
ࢩࢢࢼࣝఏ㐩ᅉᏊࡢศᕸࡣ⣽⬊እ࡟Ꮡᅾࡍࡿ⢾ࢱࣥࣃࢡ㉁ࡢ୍✀ࠊࢢࣜࣆ࢝ࣥࡢാࡁ࡟ࡼࡾไᚚࡉࢀࡿ
ࡇ࡜ࢆ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋᮏ◊✲ࡢᡂᯝࡣࠊ⤌⧊ෆ࡟࠾ࡅࡿ⣽⬊ྠኈࡢⓗ☜࡞᝟ሗఏ㐩ࡸࠊࡑࢀ࡟క
࠺⣽⬊ࡢᣲືࡸ⤌⧊ࡢᙧែᙧᡂ࡞࡝ࢆ⌮ゎࡍࡿୖ࡛㔜せ࡞ᇶ♏ⓗ▱ぢ࡛ࡍࠋࡇࡢᡂᯝࡣ⏕≀་Ꮫ⣔ࡢ◊✲⪅࡟ࡼࡾ㑅ᐃࡉࢀࡿ)DFXOW\RI ࡟㑅ࡤࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE<$+22ࠊ :HE࣐࢖ࢼࣅࠊ ᪥ᮏ⤒῭᪂⪺  㠃

− 188 −

 ᖺ  ᭶  ᪥࢔ࣈ࣒ࣛࢩ࡜⣽⳦ࡀඹ⏕ࡍࡿ⣽⬊࡛ࡣࡓࡽࡃ᪂ࡋ࠸㑇ఏᏊࣇ࢓࣑࣮ࣜࢆⓎぢ
Shigenobu, S., and Stern, D. (2013). Aphids evolved novel secreted proteins forsymbiosis with bacterial endosymbiont. Proc. Biol. Sci. 280, 20121952.
 ᪻⹸ࡢ࢔ࣈ࣒ࣛࢩ㸦࢔࣐ࣜ࢟㸧ࡢ⣽⬊ෆ࡟ࡣࣈࣇࢿࣛ࡜࿧ࡤࢀࡿඹ⏕⣽⳦ࡀ᳇ࢇ࡛࠾ࡾࠊ࠾஫࠸┦ᡭ↓ࡋ࡛ࡣ⏕ࡁ࡚࠸ࡅ࡞࠸࡯࡝⥭ᐦ࡞ඹ⏕㛵ಀࢆ⠏࠸࡚࠸ࡲࡍࠋከࡃࡢ◊✲⪅ࡀ࢔ࣈ࣒ࣛࢩ࡜ࣈࣇࢿࣛࡢ
ඹ⏕ࢆᨭ࠼ࡿ௙⤌ࡳࢆ◊✲ࡋ࡚ࡁࡲࡋࡓࡀࠊ࡝ࡢࡼ࠺࡞㑇ఏᏊࡀ㛵ࢃࡗ࡚࠸ࡿ࠿࡟ࡘ࠸࡚ࡣࠊࡇࢀࡲ࡛
࠶ࡲࡾศ࠿ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤ⏕≀ᶵ⬟ゎᯒࢭࣥࢱ࣮ࡢ㔜ಙ⚽἞≉௵෸ᩍᤵ࡜⡿ᅜࣉࣜࣥࢫࢺࣥ኱Ꮫࡢ 'DYLG6WHUQ ᩍᤵࡣࠊ࢔ࣈ࣒ࣛࢩ࡟࠾࠸࡚ࣈࣇࢿࣛࡀඹ⏕ࡍࡿ⣽⬊࡛ാࡃ᪂ࡋ࠸㑇ఏᏊ⩌ࢆⓎぢࡋࠊ%&5 ࠾ࡼࡧ 63 ࣇ࢓࣑࣮ࣜ࡜࿨ྡࡋࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣࠊ3URFHHGLQJVRIWKH
5R\DO6RFLHW\% ⱥᅜ⋤❧༠఍⣖せ ࡢ㟁Ꮚ∧࡟Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
 %&5 ࡜ 63 㑇ఏᏊ⩌ࡢⓎ⌧ࡣ࠸ࡎࢀࡶࠊ࢔ࣈ࣒ࣛࢩࡢ⬇࡟ࣈࣇࢿࣛࡢឤᰁࡋࡓ┤ᚋ࡟㛤ጞࡋࠊ௨㝆࢔ࣈ࣒ࣛࢩࡢ୍⏕ࢆ㏻ࡋ࡚ඹ⏕ჾᐁ≉␗ⓗ࡞Ⓨ⌧ࢆ⥔ᣢࡋࡲࡍࠋࡇࢀࡽࡢ㑇ఏᏊࡢࢥ࣮ࢻࡍࡿࢱࣥࣃࢡ㉁ࡣ
ࡍ࡭࡚⣽⬊እศἪࢩࢢࢼࣝ㓄ิࢆᣢࡕࠊ࡞࠿࡛ࡶ %&5 ࡣࢩࢫࢸ࢖ࣥṧᇶࢆከࡃྵࡴ▷࠸࣌ࣉࢳࢻ࡛࠶ࡿ
࡞࡝≉ᚩⓗ࡞ᵓ㐀ࢆᣢࡗ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡾࡲࡋࡓࠋࡇࡢ⤖ᯝࡣࠊ௒ᅇⓎぢࡋࡓ࢔ࣈ࣒ࣛࢩࡢ᪂つ㑇ఏᏊ⩌ࡀࣈࣇࢿࣛ࡜ࡢඹ⏕࡟㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿࡇ࡜ࢆ♧၀ࡋ࡚࠸ࡲࡍࠋ㏆ᖺࠊ࣐࣓⛉᳜≀࡜᰿⢏⳦ࡢඹ⏕࡟࠾࠸࡚ࡶࢩࢫࢸ࢖ࣥṧᇶࢆྵࡴ▷࠸࣌ࣉࢳࢻࡀඹ⏕ࢩࢫࢸ࣒ࡢ⥔ᣢ࡜ไᚚ࡟㔜せ࡞ᙺ๭ࢆᯝ
ࡓࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠾ࡾࠊື᳜≀ࢆ㉺࠼ࡓඹ⏕ࢩࢫࢸ࣒㐍໬ࡢඹ㏻ཎ⌮ࡢᏑᅾࢆ♧၀ࡍࡿࡶࡢ
࡜ࡋ࡚ࠊ௒ᚋࡢ◊✲ᒎ㛤ࡀᮇᚅࡉࢀࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 :HE<$+22ࠊ :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺  㠃

− 189 −

 ᖺ  ᭶  ᪥㧊㠧ᙧᡂࡢไᚚᶵᵓࡢゎ᫂ࠥ⬺㧊⑌ᝈࡢ἞⒪⸆㛤Ⓨ࡟ྥࡅࡓ᪂ࡓ࡞ᶆⓗศᏊࡢⓎぢࠥ
Kuboyama, K., Fujikawa, A., Masumura, M., Suzuki, R., Matsumoto, M., and Noda, M.
(2012). Protein tyrosine phosphatase receptor type Z negatively regulates oligodendrocyte
differentiation and myelination. PLoS ONE , e48797.
ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭⤫ྜ⚄⤒⏕≀Ꮫ◊✲㒊㛛㸦㔝⏣ᫀᬕᩍᤵ㸧࡜࢔ࢫࣅ࢜ࣇ࢓࣮࣐ᰴᘧ఍♫ࡢ◊✲ࢢࣝ
࣮ࣉࡣࠊ3WSU] ࡜࠸࠺ࢱࣥࣃࢡ㉁ࢳࣟࢩࣥ⬺ࣜࣥ㓟໬㓝⣲ࡀࠊ୰ᯡ⚄⤒⣔࡟࠾ࡅࡿ㧊㠧㸦࣑࢚ࣜࣥ㠧㸧ࡢᙧᡂ㸭෌ᙧᡂࡢไᚚ࡟㛵ࢃࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡣࠊ3WSU] ࢆḞኻࡉࡏࡓ࣐࢘ࢫ
࡛ࡣࠊⓎ⏕ᮇࡢ⬻ෆ࡟࠾࠸࡚㧊㠧ࡢᙧᡂ㛤ጞࡀ᪩ࡲࡗ࡚࠾ࡾࠊࡲࡓᡂయ࡟࠾࠸࡚ࡶࠊᐇ㦂ⓗ࡞⬺㧊࡟ᑐࡋ࡚᢬ᢠᛶࡀ࠶ࡾ㧊㠧ࡢ෌ᙧᡂ⬟ࡀஹ㐍ࡋ࡚࠸ࡿࡇ࡜ࢆぢ࠸ࡔࡋࡲࡋࡓࠋศᏊ࣭⣽⬊ࣞ࣋ࣝࡢゎᯒ࠿ࡽࠊ㧊㠧ࡢᙧᡂ࡟㛵ࢃࡿ⣽⬊ෆࢩࢢࢼࣝఏ㐩࡟ᑐࡋ࡚ 3WSU] ࡀᢚไⓗ࡟ാࡃ௙⤌ࡳࡶ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋ
ࡇࢀࡽࡢᡂᯝࡣࠊ⚄⤒㍈⣴ࡢ㧊㠧ࡀᙧᡂࡉࢀࡿไᚚ࣓࢝ࢽࢬ࣒ࡢ୍➃ࢆゎࡁ᫂࠿ࡍࡶࡢ࡛࠶ࡾࠊ㞴⑓࡛
࠶ࡿከⓎᛶ◳໬⑕➼ࡢ⬺㧊⑌ᝈ࡟ᑐࡋ࡚ࠊ㧊㠧ࡢ෌ᙧᡂࢆಁࡍ᪂ࡋ࠸ࢱ࢖ࣉࡢ἞⒪⸆ࡢ㛤Ⓨ࡟࠾࠸࡚ࡶ
኱࠸࡟ᙺ❧ࡘ▱ぢ࡛ࡍࠋᮏ◊✲ᡂᯝࡣࠊ᪥ᮏ᫬㛫  ᭶㸶᪥࡟ 3/2621( ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺ 㠃ࠊ :HE࣐࢖ࢼࣅ


− 190 −

ࠊ :HE<$+22  ᖺ  ᭶  ᪥᰿⢏ࡢᙧ࡙ࡃࡾ࡟࠾ࡅࡿ࣮࢜࢟ࢩࣥࡢస⏝ᶵᵓࢆゎ᫂
6X]DNL 7 <DQR . ,WR 0 8PHKDUD < 6XJDQXPD 1 DQG .DZDJXFKL 0  
3RVLWLYHDQGQHJDWLYHUHJXODWLRQRIFRUWLFDOFHOOGLYLVLRQGXULQJURRWQRGXOHGHYHORSPHQWLQ
/RWXVMDSRQLFXVLVDFFRPSDQLHGE\DX[LQUHVSRQVH'HYHORSPHQW ᇶ♏⏕≀Ꮫ◊✲ᡤඹ⏕ࢩࢫࢸ࣒◊✲㒊㛛ࡢᑑᓮᣅဢຓᩍ࡜ᕝཱྀṇ௦ྖᩍᤵࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ࣐࣓
⛉᳜≀࡜ᅵተࣂࢡࢸࣜ࢔ࡢ᰿⢏⳦ࡀ⏕≀㛫┦஫స⏝㸦ඹ⏕㸧ࢆ⾜࠺ჾᐁ࡛࠶ࡿ᰿⢏ࡢⓎ⏕࡟࠾࠸࡚ࠊ᳜
≀࣍ࣝࣔࣥࡢ࣮࢜࢟ࢩࣥࡀస⏝ࡍࡿᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡇࡢ◊✲ᡂᯝࡣࠊ⏕≀Ꮫᑓ㛛ㄅ
'HYHORSPHQW ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ ◊✲ࢢ࣮ࣝࣉࡣࠊ᳜≀ࡢ⏕㛗࡟㔜せ࡞࡛࣍ࣝࣔࣥ࠶ࡿ࣮࢜࢟ࢩࣥ࡟ὀ┠ࡋࠊ࣮࢜࢟ࢩࣥࡀ᰿⢏ᙧᡂࡢලయⓗ࡟࡝ࡢⓎ⏕㐣⛬࡛࡝ࡢࡼ࠺࡞ศᏊᶵᵓ࡟ࡼࡾ᰿⢏ࡢⓎ⏕ࢆไᚚࡋ࡚࠸ࡿࡢ࠿ࢆㄪ࡭ࡲࡋࡓࠋ࣑ࣖ
ࢥࢢࢧ࡜࠸࠺࣐࣓⛉ࡢࣔࢹ᳜ࣝ≀ࢆ◊✲ᮦᩱ࡟ࡋ࡚ࠊ࣮࢜࢟ࢩࣥࡀᏑᅾࡋ࡚࠸ࡿᡤ࡛⺯ගࢱࣥࣃࢡ㉁ࡀ
ගࡿ᳜≀ࢆసࡾฟࡋࡲࡋࡓࠋࡇࡢ᳜≀ࢆ౑ࡗ࡚ࠊ᰿⢏ࡢᙧᡂ㐣⛬࡛᰿ࡢ࡝ࡇ࡟࣮࢜࢟ࢩࣥࡀᏑᅾࡋ࡚࠸
ࡿࡢ࠿ࢆㄪ࡭ࡓ࡜ࡇࢁࠊ࣮࢜࢟ࢩࣥࡢ⵳✚ࣃࢱ࣮ࣥࢆヲ⣽࡟࡜ࡽ࠼ࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊᑗ᮶᰿⢏ࡀศ໬ࡍࡿ⓶ᒙ࡜࿧ࡤࢀࡿ⤌⧊ࡢ⣽⬊ศ⿣࡟ඛ❧ࡗ࡚࣮࢜࢟ࢩࣥࡀ⵳✚ࡋࠊ⣽⬊ศ⿣࡜ྠㄪⓗ࡟࣮࢜࢟ࢩࣥࡀ⵳✚ࡍࡿࡇ࡜࡟ࡼࡾ᰿⢏ࡢཎᇶࡀࡘࡃࡽࢀࡿࡇ࡜ࡀࢃ࠿ࡾࡲࡋࡓࠋ ᮏ◊✲࡟ࡼࡗ࡚ࠊྂࡃ࠿ࡽ᰿⢏ᙧᡂ࡟࠾ࡅࡿ㛵୚ࡢ㔜せᛶࡀ♧၀ࡉࢀ࡚࠸ࡓ࣮࢜࢟ࢩࣥ࡜᰿⢏ࡢⓎ⏕ࡢ㛵ࢃࡾࡀึࡵ࡚㑇ఏᏊ࡛ࣞ࣋ࣝヲ⣽࡟᫂ࡽ࠿࡟࡞ࡾࠊ᰿⢏ࡢⓎ⏕ࢆไᚚࡍࡿ࣓࢝ࢽࢬ࣒ࡢ⌮ゎࡀ῝ࡲࡾࡲࡋࡓࠋࡉࡽ࡟ࠊᮏ◊✲࡟ࡼࡾࠊ᰿⢏ࢆᙧᡂࡍࡿ㝿࡟㉳ࡇࡿ⓶ᒙࡢ⣽⬊ศ⿣ࢆࠊศ⿣ࡢ㐍⾜ᗘྜ࠸࡟ࡼࡗ࡚ཝᐦ࡟ไᚚࡍࡿ᪂ࡓ࡞ᶵᵓࡢᏑᅾࡶ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺  㠃

− 191 −

 ᖺ  ᭶  ᪥㟋㛗㢮ࡢ⚄⤒ᅇ㊰ࢆྍど໬ࡍࡿ᪂ࡋ࠸ࢶ࣮ࣝࢆ㛤Ⓨ
Watakabe, A., Kato, S., Kobayashi, K., Takaji, M., Nakagami, Y., Sadakane, O., Ohtsuka,
M., Hioki, H., Kaneko, T., Okuno, H., Kawashima, T., Bito, H., Kitamura, Y., andYamamori, T. (2012). Visualization of cortical projection neurons with retrograde TET-off
lentiviral vector. PLoS ONE , e46157.
⮬↛⛉Ꮫ◊✲ᶵᵓ࣭ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᒣ᳃ဴ㞝ᩍᤵ࣭Ώᡃ㒊᫛ဢ෸ᩍᤵࡽ࡜⚟ᓥ┴❧་኱ࡢᑠᯘ࿴ே
ᩍᤵ࣭ຍ⸨ᡂᶞㅮᖌࠊཬࡧி㒔኱Ꮫࠊᮾி኱Ꮫࠊᅜ㝿་⒪⚟♴኱Ꮫࡢඹྠ◊✲ࢳ࣮࣒ࡣࠊ᪂ࡋ࠸㧗Ⓨ⌧࢘࢖ࣝࢫ࣋ࢡࢱ࣮㸦㏫⾜ᛶ 7(72II ࣋ࢡࢱ࣮㸧ࢆ⏝࠸ࡿࡇ࡜࡛ࠊ≉ᐃࡢ㒊఩࡟ᢞᑕࡍࡿ⚄⤒⣽⬊ࡢ඲యീࢆྍど໬ࡍࡿ᪂ࡓ࡞᪉ἲࢆ㛤Ⓨࡋࡲࡋࡓࠋࡇࡢᡭἲ࡛ࡣࠊᢠయᰁⰍࢆࡍࡿࡇ࡜࡞ࡃࠊ⺯ගࢱࣥࣃࢡ㉁ࢆ┤᥋ࠕぢࡿࠖࡇ࡜࡟ࡼࡾࠊᶞ≧✺㉳ࡸ㍈⣴ࡲ࡛ヲ⣽࡟ほᐹࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋࡇࡢ࢘࢖ࣝࢫ࣋ࢡࢱ
࣮ࢆࠊ㟋㛗㢮࡛࠶ࡿ᪂ୡ⏺ࢨࣝࡢ࣐࣮ࣔࢭࢵࢺࡢ኱⬻⓶㉁࡟ὀධࡋࡓ࡜ࡇࢁࠊFP㸦⣽⬊యࡢ኱ࡁࡉࡢ⣙ ಸ㸧ࡢ㊥㞳ࢆ㉸࠼࡚ࠊ཯ᑐഃࡢ኱⬻⓶㉁࡟ᢞᑕࡍࡿ⓶㉁⚄⤒⣽⬊ࢆྍど໬ࡍࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋ
ᮏ◊✲ᡂᯝࡣࠊ⡿ᅜ⛉Ꮫㄅࣉࣟࢫ࣡ࣥ㸦 ᭶  ᪥ྕ㟁Ꮚ∧㸧
㸦KWWSZZZSORVRQHRUJ㸧࡛බ㛤ࡉࢀࡲࡋࡓࠋ࡞࠾ࠊᮏ◊✲ࡣࠊᩥ㒊⛉Ꮫ┬⬻⛉Ꮫ◊✲ᡓ␎᥎㐍ࣉࣟࢢ࣒ࣛࡢ୍⎔࡜ࡋ࡚ࠊࡲࡓ⛉Ꮫ◊✲㈝⿵ຓ
㔠࡞࡝ࡢຓᡂࢆཷࡅ࡚⾜ࢃࢀࡲࡋࡓࠋ
㸺ᮏᡂᯝࡢ࣏࢖ࣥࢺ㸼x⬻ࡢࡉࡲࡊࡲ࡞⚄⤒⣽⬊ࢆ⮬ᅾ࡟͆ྍど໬͇ࡍࡿ㑇ఏᏊᑟධἲࢆ㛤Ⓨࡋࡲࡋࡓࠋ

xຠ⋡ࡢⰋ࠸Ⓨ⌧ቑᖜἲࡢ᥇⏝࡟ࡼࡾࠊᶞ≧✺㉳࠿ࡽ㍈⣴ࡲ࡛ヲ⣽࡞ᙧែࡀྍど໬࡛ࡁࡲࡋࡓࠋ

xࡇࡢ᪉ἲࢆ౑ࡗ࡚ࠊ㟋㛗㢮ࡢࣔࢹࣝ⏕≀࡛࠶ࡿ࣐࣮ࣔࢭࢵࢺࡢ኱⬻⓶㉁ᑐഃᢞᑕ⚄⤒⣽⬊ࡢᙧែࢆㄪ࡭ࡿࡇ࡜࡟ᡂຌࡋࡲࡋࡓࠋ

᪂⪺ሗ㐨➼㸸 :HEMLMLࠊ :HE<$+22ࠊ :HE᪥หᕤᴗ᪂⪺ࠊ ᪥หᕤᴗ᪂⪺ 㠃ࠊ ᪥⤒⏘ᴗ᪂⪺ 㸵㠃ࠊ :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺  㠃

− 192 −

 ᖺ  ᭶  ᪥᳜≀ࡢⱼⴥࡢ㉳※࡟㏕ࡿ㑇ఏᏊࡢⓎぢ
Aoyama, T., Hiwatashi, Y., Shigyo, M., Kofuji, R., Kubo, M., Ito, M., and Hasebe, M.
(2012). AP2-type transcription factors determine stem cell identity in the moss
3K\VFRPLWUHOODSDWHQV. Development, 3120-3129.
ᇶ♏⏕≀Ꮫ◊✲ᡤ㸦⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ㸧ࡢ㟷ᒣ๛ኈ༤ኈㄢ⛬኱Ꮫ㝔⏕࡜㛗㇂㒊ගὈᩍᤵࢆ୰ᚰ࡜ࡍࡿ
◊✲ࢢ࣮ࣝࣉࡣࠊ᳜≀ࡢⱼⴥࡢ㉳※࡟㏕ࡿ㑇ఏᏊ $3% ࢆぢࡘࡅࡲࡋࡓࠋࡇࢀ࡟ࡼࡾࠊ᳜≀ࡀ࡝ࡢࡼ࠺࡟
㝣ୖ࡛㐍໬ࡋ࡚ࡁࡓࡢ࠿࡟ࡘ࠸࡚◊✲ࡀ㐍ᒎࡍࡿࡇ࡜ࡀᮇᚅࡉࢀࡲࡍࠋᮏ◊✲ᡂᯝࡣࠊⱥᅜⓎ⏕Ꮫᑓ㛛ㄅ'HYHORSPHQW ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᳜≀ࡣගྜᡂ࡛ᰤ㣴ศࢆసࡾࡲࡍࠋගࢆồࡵ࡚ࠊࡓࡃࡉࢇࡢⴥࢆࡘࡅࡓⱼࢆఙࡤࡋࠊ஫࠸࡟➇தࡍࡿࡇ࡜࡛ࠊ᳜≀ࡣ࡝ࢇ࡝ࢇ኱ࡁࡃ࡞ࡾࡲࡋࡓࠋࡋ࠿ࡋࠊ㝣࡟࠶ࡀࡗ࡚ࡍࡄࡢ㡭ࡣࠊⱼࡸⴥࢆᣢࡗ࡚࠸࡞࠿ࡗ
ࡓࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡲࡍࠋ࡛ࡣࠊ᳜≀ࡣ࡝ࡢࡼ࠺࡟ⱼࡸⴥࢆ㐍໬ࡉࡏࡓࡢ࡛ࡋࡻ࠺࠿ࠋࢥࢣ᳜≀ࢭࣥ㢮ࡣࡇࡢၥ㢟ࢆゎỴࡍࡿࡢ࡟㐺ࡋࡓᮦᩱ࡛ࡍࠋ࡞ࡐ࡞ࡽࠊỈࡢ୰࡟ఫࡴ⸴㢮࡟ఝࡓ⣽⬊ศ⿣ࡸᡂ㛗ᵝᘧࢆᣢࡘ⣒≧ࡢయ㸦ཎ⣒య㸧࡜ᆅୖ࡟㐺ᛂࡋࡓⱼⴥࢆసࡿయ㸦ⱼⴥయ㸧ࢆ⎔ቃ࡟ࡼࡗ࡚సࡾศࡅ࡚࠸ࡿ࠿ࡽ
࡛ࡍࠋ◊✲ࢢ࣮ࣝࣉࡣࠊࢥࢣ᳜≀ࣄ࣓ࢶࣜ࢞ࢿࢦࢣࢆ⏝࠸ࠊⱼⴥࢆసࡿࡢ࡟ᚲ㡲࡞㑇ఏᏊ $3% ࢆⓎぢࡋࡲࡋࡓࠋ
ࡇࡢ㑇ఏᏊࡣከࡃࡢ㑇ఏᏊࢆไᚚࡍࡿ㑇ఏᏊ㸦㌿෗ᅉᏊ㸧࡛ࠊቯࡍ࡜ⱼⴥయࡀ࡛ࡁࡎࠊཎ⣒యࡔࡅࡋ࠿
సࢀ࡞ࡃ࡞ࡗ࡚ࡋࡲ࠸ࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 ୰᪥᪂⪺  㠃ࠊ :HE୰᪥⎔ቃ QHWࠊ :HE<$+22ࠊ ⛉Ꮫ᪂⪺  㠃

− 193 −

 ᖺ  ᭶  ᪥ᶆ㆑ࡏࡎ࡟ศᏊࢆぢࡿගࢩ࣮ࢺᆺࡢ࣐ࣛࣥ㢧ᚤ㙾ࢆ㛤Ⓨ࣓ࠥࢲ࢝⛶㨶ࡢ⹿Ⰽ⣲⬊ࡢศᏊ࢖࣓࣮ࢪࣥࢢ࡟ᡂຌ㹼
2VKLPD < 6DWR + .DMLXUD.RED\DVKL + .LPXUD 7 1DUXVH . DQG 1RQDND 6  /LJKW VKHHWH[FLWHG VSRQWDQHRXV 5DPDQ LPDJLQJ RI D OLYLQJ ILVK E\ RSWLFDOVHFWLRQLQJLQDZLGHILHOG5DPDQPLFURVFRSH2SWLFV([SUHVV ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㔝୰ⱱ⣖෸ᩍᤵ࡜኱ᔱభ௓◊✲ဨ㸦⌧ឡ፾኱Ꮫ་Ꮫ㒊ຓᩍ㸧ࡽࡣࠊࢩ࣮ࢺ≧࡟ᩚᙧࡋࡓ࣮ࣞࢨ࣮ࣅ࣮࣒ࢆヨᩱ࡟↷ᑕࡋࠊගࡢ↷ᑕ㠃࡟ᑐࡋ࡚ᆶ┤࡞᪉ྥ࠿ࡽ⏬ീࢆ᧜ᙳࡍࡿ᪉ᘧࡢ㢧ᚤ㙾㸦ගࢩ࣮ࢺᆺ㢧ᚤ㙾㸧࡜ࠊ↓ᰁⰍ࡛ศᏊࢆྍど໬࡛ࡁࡿ࣐ࣛࣥ㢧ᚤ㙾ࡢཎ⌮ࢆ⤌ࡳྜࢃࡏࡓࠕගࢩ
࣮ࢺᆺ࣐ࣛࣥ㢧ᚤ㙾ࠖࢆ㛤Ⓨࡋࠊ⏕ࡁࡓ࣓ࢲ࢝⛶㨶ࡢ⹿Ⰽ⣲⬊࡟ྵࡲࢀࡿࢢ࢔ࢽࣥศᏊࡢ࣐ࣛࣥ࢖࣓࣮
ࢪࣥࢢ࡟ᡂຌࡋࡲࡋࡓࠋගࢩ࣮ࢺᆺ㢧ᚤ㙾ἲ࡟ࡼࡿ⏕య࣐ࣛࣥ࢖࣓࣮ࢪࣥࢢࡢሗ࿌ࡣୡ⏺ึ࡛ࡍࠋ
㟁ᏊไᚚἼ㛗ྍኚࢳࢱࣥࢧࣇ࢓࢖࢔࣮ࣞࢨ࣮࡜࠸࠺≉Ṧ࡞࣮ࣞࢨ࣮ග※ࢆ⏝࠸࡚ࠊ⏕ࡁࡓ࣓ࢲ࢝ࡢ⛶㨶ࢆほᐹࡋࡓ࡜ࡇࢁࠊ║⌫ࠊ⬚㫅௜㏆ࡢ⹿Ⰽ⣲⬊࠿ࡽࢩࢢࢼࣝࢆᤊ࠼ࡲࡋࡓࠋ⹿Ⰽ⣲⬊࡟ࡣࢢ࢔ࢽࣥࢆྵ
ࡴࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊ࣐ࣛࣥศගἲ࡟ࡼࡿࢫ࣌ࢡࢺࣝゎᯒࡢ⤖ᯝࠊࢢ࢔ࢽࣥศᏊࡢ࢖࣓࣮ࢪ࡛࠶ࡿࡇ
࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡇࡢࡼ࠺࡞↓ᶆ㆑ศᏊ࢖࣓࣮ࢪࣥࢢࡢᢏ⾡ࡣࠊᑗ᮶ⓗ࡟ࡣࡓ࡜࠼ࡤࣞࢳࣀ࢖
ࣥ㓟ࡸᒀ㓟࡜࠸ࡗࡓࠊ⏕యෆ࡛ࡢศᕸࡀ㔜せ࡞ព࿡ࢆᣢࡘࢱࣥࣃࢡ㉁௨እࡢศᏊࡢ࢖࣓࣮ࢪࣥࢢ࡟ᛂ⏝࡛ࡁࡿྍ⬟ᛶࡀ࠶ࡾࡲࡍࠋ௒ᚋࡣࠊࣅ࣮࣒ᩚᙧࢆࡼࡾ⢭ᐦ࡟ไᚚࡋࠊ㧗ಸ⋡࠿ࡘ㩭᫂࡞⏬ീࢆྲྀᚓ࡛ࡁ
ࡿࡼ࠺࡟㢧ᚤ㙾ࢆᨵⰋࡋࠊ⣽⬊࡛ࣞ࣋ࣝࡢゎᯒࢆ⾜࠺ࡇ࡜࡟ࡼࡗ࡚ࠊ⤌⧊ࡢⓎ⏕ࡸ⣽⬊ศ໬ࠊᙧែᙧᡂ
࡟࠿࠿ࢃࡿศᏊࡢᶵ⬟ࡸࢲ࢖ࢼ࣑ࢡࢫ࡟㏕ࡿ㠉᪂ⓗ࡞ᢏ⾡࡜ࡋ࡚ᮇᚅ࡛ࡁࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺  㠃

− 194 −

 ᖺ  ᭶  ᪥࣓ࢲ࢝ࡢᢠ࣑࣮ࣗࣛ⟶࣍ࣝࣔࣥ㸦$0+㸧⣔ࡣ༸ࡸ⢭Ꮚࡢᩘࢆ㐺ษ࡟ಖࡘᙺ๭ࢆᣢࡘ
Nakamura, S., Watanabe, I., Nishimura, T., Picard, J-Y., Toyoda, A., Taniguchi, Y., di
Clemente, N., and Tanaka, M.  Hyperproliferation of mitotically active germ cells
dues to defective anti-Müllerian hormone signaling mediates sex reversal in medaka.
Development , 2283-2287.
ᇶ♏⏕≀Ꮫ◊✲ᡤ⏕Ṫ㑇ఏᏛ◊✲ᐊࡢ⏣୰ᐇ෸ᩍᤵ࡜୰ᮧಟᖹ◊✲ဨࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ࣓ࢲ࢝ࢆ
⏝࠸ࡓ◊✲࡟ࡼࡾࠊᢠ࣑࣮ࣗࣛ⟶࣍ࣝࣔࣥ㸦$0+㸧⣔ࡀ༸ࡸ⢭Ꮚࡢᩘࢆ㐺ษ࡟ಖࡘᶵᵓࢆ᫂ࡽ࠿࡟ࡋࡲࡋ
ࡓࠋࡇࡢᡂᯝࡣࠊ⏕≀Ꮫᑓ㛛ㄅ 'HYHORSPHQW ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ ே㛫ࡢ⏨ᛶ⫾ඣ࡛ࡣࠊᢠ࣑࣮ࣗࣛ⟶࣍ࣝࣔࣥ㸦$0+㸧⣔࡜࿧ࡤࢀࡿᅉᏊࡀศἪࡉࢀ࡚༸⟶ࡸ⭼ࢆసࡾฟࡍ⤌⧊ࡀ㏥⦰ࡍࡿࡢ࡟ᑐࡋࠊዪᛶ⫾ඣࡣࡇࡢᅉᏊࡀศἪࡉࢀࡎࡑࡢࡲࡲ༸⟶ࡸ⭼ࡀⓎ㐩ࡋࡲࡍࠋ$0+ ⣔㑇ఏᏊࡣࠊከࡃࡢື≀࡟ࡶඹ㏻ࡋ࡚Ꮡᅾࡍࡿᇶᮏⓗ࡞㑇ఏᏊ࡛࠶ࡾ࡞ࡀࡽࠊࣄࢺࡢࡼ࠺࡞ዪᛶ⏕Ṫჾᐁࢆᣢࡘື≀ࡣࡈࡃ୍㒊࡛࠶ࡾࠊ௚࡟ᶵ⬟ࡀ࠶ࡿࡢ࠿ࠊ௚ࡢື≀࡛ࡣ࡝ࡢࡼ࠺࡞ᶵ⬟ࢆᢸࡗ࡚࠸ࡿࡢ࠿ㅦ
࡛ࡋࡓࠋ௒ᅇ࣓ࢲ࢝࡟࠾࠸࡚ࠊ$0+ ⣔ࡣࠊࡈࡃ୍㒊ࡢᖿ⣽⬊ᵝࡢ⏕Ṫ⣽⬊ࢆไᚚࡍࡿࡇ࡜࡛༸ࡸ⢭Ꮚࡢ඲యࡢᩘࢆไᚚࡋ࡚࠸ࡿ㔜せ࡞ᅉᏊ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࡲࡋࡓࠋࡋ࠿ࡶ $0+ ⣔ࡣࠊ┤᥋ࡣ⏕Ṫ⣽⬊࡟ࡣᣦ௧ࢆ㏦ࡽࡎ࡟ࠊ࿘ࡾࡢయ⣽⬊ࡀฟࡍᮍࡔṇయࡢ᫂ࡽ࠿࡛࡞࠸ቑṪᣦ௧ࢆ௓ࡋ࡚ࠊ⏕Ṫ⣽⬊ࡢᩘࢆไᚚࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࠊᛶࡸ⏕Ṫ⭢ࡢ኱ࡁࡉࡣࠊ⏕Ṫ⣽⬊ࡢቑṪไᚚࢆ㏻ࡌ࡚㛫᥋ⓗ࡟ไᚚࡉࢀ࡚࠸ࡿ࡜࠸࠺௙⤌ࡳࡀึࡵ࡚᫂ࡽ࠿࡜࡞ࡾࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅ

− 195 −

 ᖺ  ᭶  ᪥⬻ࡢᒙᵓ㐀ࢆసࡿศᏊࢆⓎぢ
Shintani, T., Takeuchi, Y., Fujikawa, A., and Noda, M. (2012). Directional neuronalmigration is impaired in mice lacking adenomatous polyposis coli 2. J. Neurosci. ,
6468-6484.
ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭⤫ྜ⚄⤒⏕≀Ꮫ◊✲㒊㛛ࡢ᪂㇂㝯ྐ෸ᩍᤵ࡜㔝⏣ᫀᬕᩍᤵࡽࡣࠊ$3& $GHQRPDWRXVSRO\SRVLVFROL ࡜࠸࠺⬻⚄⤒⣔࡟Ⓨ⌧ࡍࡿศᏊࡢᶵ⬟ࢆ᫂ࡽ࠿࡟ࡍࡿ◊✲ࢆ㐍ࡵ࡚࠸ࡲࡍࠋྠࢢ࣮ࣝ
ࣉ࡛ࡣࠊ$3& 㑇ఏᏊࢆḞኻࡉࡏࡓ࣐࢘ࢫ㸦$3& ࢆാ࠿࡞ࡃࡋࡓ࣐࢘ࢫ㸧ࢆసᡂࡋࠊࡑࡢ⬻࡟࠾ࡅࡿ␗ᖖ
ࢆゎᯒࡋࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ$3& ࢆḞኻࡋࡓ࣐࢘ࢫࡢ⬻࡛ࡣࠊ⚄⤒⣽⬊ࡢ⛣ື࡟␗ᖖࡀ࠶ࡾࠊ኱⬻⓶㉁ࠊ
ᾏ㤿ࠊᑠ⬻࡞࡝ࡢᵝࠎ࡞㡿ᇦ࡛ࠊ⚄⤒⣽⬊ࡢṇᖖ࡞ᒙᵓ㐀ࡀᙧᡂࡉࢀ࡞࠸ࡇ࡜ࢆぢฟࡋࡲࡋࡓࠋࡉࡽ࡟
ヲࡋ࠸ゎᯒࡢ⤖ᯝࠊ$3& ࡀ⣽⬊እࡢ⣽⬊⛣ືࢆᑟࡃ᝟ሗࢆࠊ⣽⬊㐠ື࡟ᚲ㡲࡛࠶ࡿ⣽⬊㦵᱁㸦࢔ࢡࢳࣥ㦵᱁࣭ᚤᑠ⟶㸧ࡢࢲ࢖ࢼ࣑ࢡࢫ㸦ᙧᡂ࣭ศゎ࣭Ᏻᐃ໬㸧࡟ṇࡋࡃ཯ᫎࡉࡏࡿ࡜࠸࠺㔜せ࡞ᙺ๭ࢆᯝࡓࡋ
࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡇࡢࡼ࠺࡞࣓࢝ࢽࢬ࣒࡛ࠊ⬻ࡢᒙᙧᡂ࡟ᚲ㡲ࡢᙺ๭ࢆࡋ࡚࠸ࡿศᏊ
ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࡢࡣึࡵ࡚ࡢࡇ࡜࡛ࡍࠋ$3& ࢆḞᦆࡋࡓ࣐࢘ࢫࡣࠊ㐠ືᶵ⬟ࡢ␗ᖖࡸࠊ࡚ࢇ࠿ࢇⓎస࡞࡝ࡢ␗ᖖࢆ♧ࡍࡇ࡜࠿ࡽࠊࣄࢺ࡟࠾࠸࡚⚄⤒⣽⬊ࡢ⛣ືࡢ␗ᖖ࡟ࡼࡗ࡚⏕ࡌࡿ⑌ᝈࡀⓎ⑕ࡍࡿ௙⤌ࡳࡸࠊࡑࢀࡽࡢ἞⒪ἲࡢ㛤Ⓨ࡟ࡘ࡞ࡀࡿྍ⬟ᛶࡀ࠶ࡾࡲࡍࠋࡇࡢᡂᯝࡣࠊ⚄⤒⛉Ꮫᑓ㛛ㄅ-RXUQDORI
1HXURVFLHQFH࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨➼㸸 :HE࣐࢖ࢼࣅࠊ ⛉Ꮫ᪂⪺  㠃ࠊ ୰᪥᪂⪺  㠃

− 196 −

 ᖺ  ᭶  ᪥ⴥࡀᖹࡓ࠸ᙧ࡟ᡂ㛗ࡍࡿ࣓࢝ࢽࢬ࣒ࢆゎ᫂
Nakata, M., Matsumoto, N., Tsugeki, R., Rikirsch, E. Laux, T., and Okada, K. (2012).
Roles of the middle domain-specific WUSCHEL-RELATED-HOMEOBOX genes in early
development of leaves in Arabidopsis. Plant Cell 24, 519-535.
ⴥࡣගࢆཷࡅ࡚ &2 ࢆ྾཰ࡋࠊᰤ㣴ศࢆసࡾฟࡍගྜᡂࢆ࠾ࡇ࡞࠺ሙᡤ࡛ࡍࠋⴥࡣ㏻ᖖࠊᖹࡓ࠸ᙧ࡛ࠊ⾲ഃ࡜⿬ഃ࡟㐪࠸ࡀ࠶ࡾࡲࡍࡀࠊࡇࢀࡽࡣከࡃࡢගࢆ㞟ࡵ࡚ຠ⋡ࡢⰋ࠸ගྜᡂࢆ࠾ࡇ࡞࠺ࡓࡵ࡟኱஦࡞≉ᚩ࡛ࡍࠋⴥࡣࠊ⾲⿬᪉ྥ࡬ࡣ࠶ࡲࡾఙࡧࡎᶓ᪉ྥ࡬ࡢఙ㛗ࡀࡼࡃ㉳ࡇࡿࡇ࡜࡛ࠊᖹࡓ࠸ᙧ࡟ᡂ㛗ࡋࡲࡍࠋ㏆ᖺࡢࢩࣟ࢖ࢾࢼࢬࢼ࡞࡝ࡢࣔࢹ᳜ࣝ≀ࢆ⏝࠸ࡓศᏊ㑇ఏᏛⓗ࡞◊✲࠿ࡽࠊ⾲ഃ࡜⿬ഃࡑࢀࡒࢀࡢᛶ㉁ࢆỴࡵࡿ୍㐃ࡢ㑇ఏᏊ⩌ࡀࠊ⾲⿬ࡢ㐪࠸ࢆ⏕ࡳฟࡍࡔࡅ࡛࡞ࡃࠊᶓ᪉ྥ࡬ࡢᡂ㛗࡟ࡶ㛵ࢃࡿࡇ࡜ࡀࢃ࠿
ࡗ࡚ࡁࡲࡋࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊᶓ᪉ྥ࡬ࡢᡂ㛗ࢆᘬࡁ㉳ࡇࡍヲࡋ࠸ࡋࡃࡳࡣࢃ࠿ࡗ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ
ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᒸ⏣ΎᏕᡤ㛗࡜୰⏣ᮍ཭ᕼ◊✲ဨࡽࢆ୰ᚰ࡜ࡍࡿ◊✲ࢢ࣮ࣝࣉࡣࠊⴥࡀࡘࡃࡽࢀࡿ
ึᮇࡢ㐣⛬࡟࠾࠸࡚ࠊ⾲ഃ㡿ᇦ࡜⿬ഃ㡿ᇦࡢ㛫ࡢ㡿ᇦ࡛ാࡃ㸰ࡘࡢ㑇ఏᏊ㸦356:2;㸧ࢆぢ࠸ࡔࡋࡲࡋࡓࠋࡑࡋ࡚ࠊࡇࡢ⾲࡜⿬ࡢ㛫ࡢ㡿ᇦ㸦୰㛫㡿ᇦ㸧࡛ാࡃ㸰ࡘࡢ㑇ఏᏊࡀࠊⴥࡢᶓ᪉ྥ࡬ࡢᡂ㛗ࢆᘬࡁ㉳ࡇࡋ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊ⡿⛉Ꮫᑓ㛛ㄅ7KH3ODQW&HOO ㄅ࡟ᥖ㍕ࡉࢀࡲࡋࡓࠋ௒ᚋࠊ᳜≀ࡢရ✀ᨵⰋ࡞࡝࡟ᙺ❧ࡘᇶ♏ࢹ࣮ࢱ࡜࡞ࡿࡇ࡜ࡀᮇᚅࡉࢀࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 ᪥⤒⏘ᴗ᪂⪺  㠃

− 197 −

 ᖺ  ᭶  ᪥⚄⤒⟶ࢆࡘࡃࡿ࡟ࡣ࿘ᅖࡢ⣽⬊ࡢືࡁࡶ㔜せ
0RULWD+.DMLXUD.RED\DVKL+7DNDJL&<DPDPRWR761RQDND6DQG8HQR1 &HOOPRYHPHQWVRIWKHGHHSOD\HURIQRQQHXUDOHFWRGHUPXQGHUOLHFRPSOHWHQHXUDOWXEHFORVXUHLQ;HQRSXV'HYHORSPHQW ⬻ࡸ⬨㧊࡜࠸ࡗࡓ୰ᯡ⚄⤒⣔ࡣࠊཷ⢭ᚋࠊయࡢᙧࡀసࡽࢀࡿࡈࡃึᮇࡢẁ㝵࡛ࠕ⚄⤒⟶ࠖ࡜࿧ࡤࢀࡿ
ࢳ࣮ࣗࣈ≧ࡢᵓ㐀࠿ࡽᙧᡂࡉࢀࡲࡍࠋࡇࡢ⚄⤒⟶ࡢᙧᡂࡀୖᡭࡃ࠸࠿࡞࠸࡜ࠊ⬻ࡸ⬨㧊ࡢᙧᡂ␗ᖖࡢཎ
ᅉ࡜࡞ࡾࡲࡍࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡢୖ㔝┤ேᩍᤵࠊ᳃⏣ோ◊✲ဨࡽࡣࠊ࢔ࣇࣜ࢝ࢶ࣓࢚࢞ࣝࢆ⏝࠸ࡓ◊✲࡟ࡼࡾࠊ⚄⤒⟶ࡢᙧᡂ࡟ࡣࠊ⚄⤒࡟࡞ࡽ࡞࠸࿘ᅖࡢ⤌⧊ࡢ⣽⬊㐠ືࡀᚲ㡲࡛࠶ࡿࡇ࡜ࢆලయⓗ࡟᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡇࡢᡂᯝࡣࠊᑓ㛛ㄅ 'HYHORSPHQW ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ⚄⤒⟶㛢㙐୙඲ࡢ⣽⬊ࠊ⤌⧊࡛ࣞ࣋ࣝࡢཎᅉゎ᫂࡟ᐤ୚ࡍࡿᡂᯝ࡛ࡍࠋ ◊✲ࢢ࣮ࣝࣉࡣࠊ⚄⤒⟶ࡢࡶ࡜࡟࡞ࡿ⚄⤒ᯈࡢ⣽⬊࡟ࡘ࠸࡚ࠊ⟶ࢆᙧᡂࡍࡿࡓࡵ࡟ᚲせ࡞⣽⬊ኚᙧࡢࡋࡃࡳࢆࡇࢀࡲ࡛࡟᫂ࡽ࠿࡟ࡋ࡚ࡁࡲࡋࡓࠋ௒ᅇࡢ◊✲࡛ࡣࠊ⚄⤒⟶࡟ࡣ࡞ࡽ࡞࠸࿘ᅖࡢ⤌⧊㸦㠀⚄⤒እ⬇ⴥ㸧ࡢ⣽⬊㐠ືࡶࠊ⚄⤒⟶ᙧᡂ࡟ᚲ㡲࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋᇶ♏⏕≀Ꮫ◊✲ᡤࡀḢᕞศᏊ⏕≀Ꮫ◊✲ᡤ㸦(0%/㸧࠿ࡽᑟධࡋࡓ᪂ᆺ㢧ᚤ㙾ࠕࢹࢪࢱࣝࢫ࢟ࣕࣥගࢩ࣮ࢺ㢧ᚤ㙾㸦'6/0㸧ࠖࢆ⏝࠸࡚ྠࢢ࣮ࣝࣉࡀ⚄⤒⟶ᙧᡂ㐣⛬ࡢ࢔ࣇࣜ࢝ࢶ࣓࢚࢞ࣝ⬇ࢆほᐹࡋࡓ࡜ࡇࢁࠊ⚄⤒⟶࡟࡞ࡽ࡞࠸㡿ᇦ㸦㠀⚄⤒እ⬇ⴥ㸧ࡢ⣽⬊ࡀ⚄⤒⟶ࡢ᪉ྥ࡟ྥ࠿ࡗ࡚㏿࠸ࢫࣆ࣮ࢻ࡛⛣ືࡋ࡚࠸ࡿࡇ࡜ࢆぢࡘࡅࡲࡋࡓࠋヲࡋࡃㄪ࡭ࡿ࡜ࠊ⛣ືࡍࡿ㠀⚄⤒እ⬇ⴥࡢ⣽⬊ᒙࡣ㸰ᒙ࠶ࡾࠊ⾲ᒙࡢ⣽⬊ࡢୗ࡟Ꮡᅾࡍࡿࠊ῝ᒙࡢ⣽⬊ᒙࡀࠊ✚ᴟⓗ࡟⫼ഃ࡬࡜⛣ືࡋ࡚࠸ࡿࡇ࡜ࡀࢃ࠿ࡾࡲࡋࡓࠋࡇࡢ῝ᒙ⣽⬊ࡢືࡁࢆ㸦⣽⬊᥋╔ࡸ⛣ື࡟㛵ࢃࡿศᏊ࢖ࣥࢸࢢࣜࣥࢆᶵ⬟㜼ᐖࡍࡿࡇ࡜࡟ࡼࡗ࡚㸧Ṇࡵࡓ࡜ࡇࢁࠊ⚄⤒⟶ࡢ㛢㙐ࡣ୙᏶඲࡞ࡶࡢ࡜࡞ࡾࡲ
ࡋࡓࠋࡲࡓࠊྠࢢ࣮ࣝࣉࡣ⬇ࡢ㠀⚄⤒እ⬇ⴥࢆ᏶඲࡟㝖ཤࡍࡿ࡜⚄⤒⟶㛢㙐ࡀ㜼ᐖࡉࢀࡿࡇ࡜ࡶ♧ࡋࡲࡋࡓࠋ ࡇࡢ◊✲࠿ࡽࠊ⚄⤒⟶ࡀ࡛ࡁࡿࡓࡵ࡟ࡣ⚄⤒⟶ࢆࡘࡃࡿ⣽⬊ࡀ⮬ᚊⓗ࡟ᙧࢆኚ࠼ࡿࡇ࡜࡟ຍ࠼࡚ࠊ⚄⤒⟶࡟࡞ࡽ࡞࠸㠀⚄⤒እ⬇ⴥࡢ⣽⬊⩌ࡢ⛣ືࡀ⟶ࢆ㛢ࡌࡿ㐣⛬ࢆ✚ᴟⓗ࡟ᡭຓࡅࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿
࡟࡞ࡾࡲࡋࡓࠋ
− 198 −

 ᖺ  ᭶  ᪥⬨᳝ື≀ࡢᛶỴᐃࡢࢩࢫࢸ࣒ࡣື≀࡟ࡼࡗ࡚␗࡞ࡿ
Nakamura, S., Watanabe, I., Nishimura, T., Toyoda, A., Taniguchi, Y., and Tanaka, M.
(2012). Analysis of medaka VR[ orthologue reveals a concerved role in germ cellmaintenance. PLoS ONE , e29982.
 ⬨᳝ື≀ࡣᚲࡎ㞤࠿㞝ࡢ࡝ࡕࡽ࠿࡟࡞ࡾࡲࡍࠋࡋ࠿ࡋࡑࡢ㞤ࡸ㞝ࢆసࡾฟࡍᛶỴᐃࢩࢫࢸ࣒ࡢ㐍໬࡟ࡘ࠸࡚ࡣヲࡋࡃุࡗ࡚࠸ࡲࡏࢇࠋࡇࢀࢆ▱ࡿࡓࡵ࡟ࡣࠊᵝࠎ࡞⏕≀ࡢᛶỴᐃࡢ௙⤌ࡳࢆㄪ࡭ࡿᚲせࡀ࠶ࡾࡲࡍࠋ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤ⏕Ṫ㑇ఏᏛ◊✲ᐊࡢ୰ᮧಟᖹࣜࢧ࣮ࢳࣇ࢙࣮ࣟ࡜⏣୰ᐇ෸ᩍᤵࡽࡣࠊ
့ங㢮࡛ࡣ㞝ࡢᛶỴᐃ࡟㔜せ࡞ാࡁࢆᣢࡘ㑇ఏᏊ࡛࠶ࡿ VR[ ࡟ὀ┠ࡋࠊ㨶㢮࡛࠶ࡿ࣓ࢲ࢝࡟࠾ࡅ࡚ᶵ⬟ゎᯒࢆ⾜࠸ࡲࡋࡓࠋࡑࡢ⤖ᯝ࣓ࢲ࢝ VR[ 㑇ఏᏊࡣࠊ့ங㢮࡜ࡣ␗࡞ࡾࠊ㞝ࡢᛶỴᐃ࡟㛵୚ࡋ࡚࠸࡞࠸ࡇ
࡜ࢆ♧ࡋࡲࡋࡓࠋࡇࡢࡇ࡜ࡣࠊᛶࢆỴࡵࡿࢩࢫࢸ࣒ࡑࡢࡶࡢࡀࠊ㐍໬ࡢ㐣⛬࡛᪂ࡓ࡟సࡾฟࡉࢀࡓࡇ࡜
ࢆ♧ࡋ࡚࠸ࡲࡍࠋ௨ୖࡢᡂᯝࡣࠊ⥲ྜᏛ⾡㞧ㄅࠕ3/R621(ࠖ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ ࣓ࢲ࢝ VR[ 㑇ఏᏊࡣ⢭ᕢ࡛ࡢࡳⓎ⌧ࡍࡿ့ங㢮࡜ࡣ␗࡞ࡾࠊ⏕Ṫᖿ⣽⬊ࡢᏑᅾࡍࡿࢽࢵࢳᵓ㐀࡛༸ᕢࡸ⢭ᕢ࡜ࡶ࡟Ⓨ⌧ࡋࡲࡍࠋ௒ᅇࡢ⤖ᯝ࡟ࡼࡾ VR[ ࡣࡇࡢࢽࢵࢳᵓ㐀࡛⏕Ṫ⣽⬊ࢆ⥔ᣢࡍࡿࡢ࡟ࡁࢃࡵ࡚㔜せ࡞ᙺ๭ࢆᣢࡘࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾࡲࡋࡓࠋྠࡌ༸ᕢ࡛ࡶ့ங㢮ࡢ༸ᕢ࡟ࡣࠊ࣓ࢲ࢝࡜㐪ࡗ࡚༸ࢆస
ࡾ⥆ࡅࡿ⏕Ṫᖿ⣽⬊ࡀ࠶ࡾࡲࡏࢇࠋࡇࢀࡣ 6R[ 㑇ఏᏊࡀ㞝໬ࡢᛶỴᐃࡢࢩࢫࢸ࣒࡟౑ࢃࢀࡿࡇ࡜࡟ࡼࡾ༸ᕢ࡛ࡢⓎ⌧ࡀኻࢃࢀ࡚ࡋࡲ࠸ࠊࡇࡢࡇ࡜ࡀࠊ⏕Ṫᖿ⣽⬊ࡀ⥔ᣢ࡛ࡁ࡞࠸୍ᅉࢆ࡞ࡋ࡚࠸ࡿ࡜⪃࠼ࡽࢀࡲࡍࠋ᪂⪺ሗ㐨➼㸸 ⛉Ꮫ᪂⪺  㠃− 199 −

 ᖺ  ᭶  ᪥࣓ࢲ࢝ࡣ⏕≀Ꮫⓗ㸯㸭㹤ࡺࡽࡂࢆ฼⏝ࡋ࡚࣑ࢪࣥࢥࢆᤕࡽ࠼ࡿ㸟 㹼ᤕ㣗⪅࡜⿕㣗⪅ࡢ㛵ಀᛶࢆᩘ⌮ࣔࢹࣝ࡜ࡋ࡚ᐃᘧ໬ࡍࡿࡇ࡜࡟ᡂຌ㹼
0DWVXQDJD:DQG:DWDQDEH(  9LVXDOPRWLRQZLWKSLQNQRLVHLQGXFHVSUHGDWLRQEHKDYLRXU6FLHQWLILF5HSRUWV ᤕ㣗ᛶື≀ࡣࠊ⣲᪩ࡃືࡁᅇࡿ⋓≀ࢆṇ☜࡟ᤕࡽ࠼ࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋ⊁ࡾࢆ⾜࠺࡜ࡁࠊᤕ㣗⪅ࡣ⏕ࡁ࡚࠸ࡿ⿕㣗⪅࡜ࡑࡢ࿘ᅖࡢ࢜ࣈࢪ࢙ࢡࢺ࡜ࡢ༊ูࢆࠊࣜ࢔ࣝࢱ࢖࣒࡛⾜࠺ᚲせࡀ࠶ࡾࡲࡍࡀࠊࡇࡢ࡜
ࡁᤕ㣗⪅ࡣᣢ࡚ࡿឤぬჾࢆ⥲ືဨࡋ࡚⏕ࡁ࡚࠸ࡿ⋓≀ࢆㄆ㆑ࡋ࡚࠸ࡲࡍࠋ≉࡟どぬ⣔ࡣከࡃࡢሙྜỴᐃⓗ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡲࡍࠋどぬࢆ㏻ࡌ࡚ࠊ኱ࡁࡉࠊᙧ≧ࠊⰍࠊࡑࡋ࡚ືࡁࢆ㆑ูࡋ࡚࿘ᅖࡢ↓㛵ಀ࡞࢜ࣈࢪ࢙ࢡࢺ࡜ࠊ⊁ࡿ࡭ࡁ⋓≀࡜ࢆࣜ࢔ࣝࢱ࢖࣒࡛༊ูࡋࡲࡍࠋ౛࠼ࡤỈ᳇⎔ቃ࡟࠾࠸࡚ື≀ࣉࣛࣥࢡࢺࣥࢆᤕ㣗ࡋ࡚࠸ࡿᑠᆺ㨶㢮ࡣࠊỈ୰ࢆ⁻࠺ከࡃࡢ⢏Ꮚࡸ◚∦࡜༊ูࡍࡿᚲせࡀ࠶ࡾࡲࡍࠋࡋ࠿ࡋ࡞ࡀ
ࡽࠊ࡝ࡢࡼ࠺࡞ࣃ࣓࣮ࣛࢱ࡟ࡼࡗ࡚༊ูࡋ࡚࠸ࡿࡢ࠿ࡣࠊࡇࢀࡲ࡛ㅦ࡟ໟࡲࢀ࡚࠸ࡲࡋࡓࠋ௒ᅇࠊᇶ♏
⏕≀Ꮫ◊✲ᡤࡢΏ㎶ⱥ἞෸ᩍᤵ࡜ᯇỌ΅◊✲ဨࡣࠊᤕ㣗⪅࡛࠶ࡿᑠᆺ㨶㢮㸦࣓ࢲ࢝㸧ࡀ⿕㣗⪅࡛࠶ࡿື≀ࣉࣛࣥࢡࢺࣥ㸦࣑ࢪࣥࢥ㸧ࢆᤕࡽ࠼ࡿ㝿ࡢ࣓ࢲ࢝ࡢどぬ⣔ࡢാࡁ࡟╔┠ࡋ࡚◊✲ࢆ⾜࠸ࠊ࣓ࢲ࢝ࡣ࣑
ࢪࣥࢥࡢ㐠ືࣃࢱ࣮ࣥ࠿ࡽ⏕ࡁ≀≉᭷ࡢືࡁࢆ▐᫬࡟ᢳฟࡋࠊࡇࢀࢆࣁࣥࢸ࢕ࣥࢢ࡟฼⏝ࡋ࡚࠸ࡿࡇ࡜
ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ࣑ࢪࣥࢥࡢ㐠ືࣃࢱ࣮ࣥࡢᩘ⌮ࣔࢹࣝ໬࡜᭱᪂ࡢࣂ࣮ࢳࣕࣝࣜ࢔ࣜࢸ࢕ᢏ⾡࡟ࡼࡾࠊࡇࡢ⏕ࡁ≀≉᭷ࡢືࡁࡣ⏕≀Ꮫⓗ㸯㸭㹤ࡺࡽࡂ࡛≉ᚩ࡙ࡅࡽࢀࡿࡇ࡜ࡀศ࠿ࡾࡲࡋࡓࠋࡇࡢᡂᯝࡣ
㸯᭶㸯㸯᪥࡟ⱥ⛉Ꮫ⥲ྜㄽᩥㄅ6FLHQWLILF5HSRUWV ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋࡼࡾຠᯝⓗ࡞㔮ࡾࡢ᪉ἲࡸ
⁺ἲ㛤Ⓨ࡞࡝࡟ά⏝ฟ᮶ࡿྍ⬟ᛶࡀ࠶ࡾࡲࡍࠋ
᪂⪺ሗ㐨➼㸸 :HE1(:6ࠊ ୰᪥᪂⪺  㠃ࠊ ẖ᪥᪂⪺  㠃ࠊ ᪥ᮏ⤒῭᪂⪺ 㠃ࠊ ୰㒊⤒῭᪂⪺ࠊ :HE<DKRRࠊ ᪥หᕤᴗ᪂⪺  㠃ࠊ ⛉Ꮫ᪂⪺  㠃

− 200 −

 ᖺ  ᭶  ᪥᳜≀࣍ࣝࣔࣥࠊࢪ࣋ࣞࣜࣥࡢฟ⌧ࡢㅦࢆୡ⏺࡛ึࡵ࡚ゎ᫂㸫᳜≀ࡢ⏕Ṫไᚚ࡬ࡢᛂ⏝࡟ᮇᚅ㸫
Aya, K., Hiwatashi, Y., Kojima, M., Sakakibara, H., Ueguchi-Tanaka, M., Hasebe, M., andMatsuoka, M. (2011). The Gibberellin perception system evolved to regulate a pre-existingGAMYB-mediated system during land plant evolution Nature Communications , article
number 544.
 ྡྂᒇ኱Ꮫ㧗➼◊✲㝔ࡢᏳ┈බ୍㑻≉௵ຓᩍ࡜ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㛗㇂㒊ගὈᩍᤵࢆ୰ᚰ࡜ࡍࡿ◊✲ࢢ࣮ࣝࣉࡣ᳜≀࣍ࣝࣔࣥࡢࢪ࣋ࣞࣜࣥࡀ᳜≀㐍໬ࡢ㐣⛬࡛࡝ࡢࡼ࠺࡟౑ࢃࢀࡿ࡟⮳ࡗࡓ࠿࡟ࡘ࠸࡚ୡ⏺
࡛ึࡵ࡚ゎ᫂ࡋࡲࡋࡓࠋࡇࢀ࡟ࡼࡾࠊ௒ᚋ᳜≀ࡢ⏕㛗࣭⏕Ṫไᚚ࡬ࡢᛂ⏝ࡶᮇᚅ࡛ࡁࡲࡍࠋ ࢪ࣋ࣞࣜࣥࡣ᳜≀ࡢ⏕㛗ࡸ⏕Ṫࢆไᚚࡍࡿ࡜▱ࡽࢀ࡚࠸ࡿࡀࠊ⣙  ൨ᖺ๓࡟ฟ⌧ࡋࡓࢥࢣ᳜≀࡟ࡣᏑᅾࡏࡎࠊࡑࡢᚋ࡟ㄌ⏕ࡋࡓࢩࢲ᳜≀࡛ึࡵ࡚౑ࢃࢀࡿࡼ࠺࡟࡞ࡗࡓ࡜⪃࠼ࡽࢀ࡚࠸ࡓࠋ௒ᅇࠊ◊✲ࢳ࣮࣒ࡣࢩࢲࠊࢥࢣࠊ࢖ࢿࡢ⬊Ꮚ㸦࢖ࢿ࡛ࡣⰼ⢊㸧ࡀฟ᮶ࡿ⏕Ṫ㐣⛬ࢆヲ⣽࡟ㄪ࡭ࡓ࡜ࡇࢁࠊࡇࡢ㐣⛬ࡣࡇࡢ  ࡘࡢ᳜≀࡛㠀ᖖ࡟ఝ࡚࠸ࡿࡀࠊ࢖ࢿ࡜ࢩࢲࡣࡇࡢ㐣⛬ࡢࢫ࢖ࢵࢳࢆධࢀࡿࡓࡵ࡟ࢪ࣋ࣞࣜࣥࡀᚲ
せ࡛࠶ࡿࡢ࡟ᑐࡋࠊࢥࢣ᳜≀ࡣࢪ࣋ࣞࣜࣥ࡞ࡋ࡛ࢫ࢖ࢵࢳࡀධࡿࡇ࡜ࡀศ࠿ࡗࡓࠋࡇࡢ⤖ᯝࡣࠊᮏ᮶ࢪ
࣋ࣞࣜࣥࡣࢥࢣ᳜≀࡟᪤࡟Ꮡᅾࡋࡓ⬊Ꮚ࣭ⰼ⢊ࡢ⏕Ṫࢩࢫࢸ࣒ࢆಁࡍࢫ࢖ࢵࢳ࡜ࡋ࡚ࠊᚋࡢࢩࢲ᳜≀ࢢ࣮ࣝࣉࡢㄌ⏕࡟కࡗ࡚Ⓩሙࡋࡓࡇ࡜ࢆ♧ࡋ࡚࠾ࡾࠊ᳜≀࣍ࣝࣔࣥࡀ᳜≀㐍໬ࡢ㐣⛬࡛࡝ࡢᵝ࡟ฟ⌧ࡋࠊࡘ࠿ࢃࢀࡿࡼ࠺࡟࡞ࡗࡓ࠿ࢆලయⓗ࡟᫂ࡽ࠿࡟ࡋࡓࠋ
᪂⪺ሗ㐨㸸 ᪥หᕤᴗ᪂⪺  㠃ࠊ ୰᪥᪂⪺  㠃ࠊ ᮅ᪥᪂⪺  㠃ࠊ :HEDVDKLFRPࠊ :HE<$+22− 201 −

 ᖺ  ᭶  ᪥
7539 ࢳࣕࣥࢿࣝࡢᾐ㏱ᅽឤཷᛶࡀ ᗘࡸ㓟࡞࡝ࡢ␗࡞ࡿ่⃭࡟ࡼࡗ࡚┦஌ⓗ࡟ቑᙉࡉࢀࡿࡇ࡜ࢆⓎぢ
1LVKLKDUD ( +L\DPD 7 DQG 1RGD 0   2VPRVHQVLWLYLW\ RI WUDQVLHQW UHFHSWRUSRWHQWLDO YDQLOORLG  LV V\QHUJLVWLFDOO\ HQKDQFHG E\ GLVWLQFW DFWLYDWLQJ VWLPXOL VXFK DV
WHPSHUDWXUHDQGSURWRQV3/RV2QHH
 ᡃࠎࡢయᾮ㸦⾑ᾮࠊ⬻⬨㧊ᾮ➼ࡢ⣽⬊እᾮ㸧ࡢᾐ㏱ᅽࡣᖖ࡟⣙ P2VPNJ ࡟ಖࡓࢀ࡚࠸ࡲࡍࠋࡇࡢయ
ᾮᜏᖖᛶࡣ⏕࿨⥔ᣢࡢࡓࡵ࡟ᚲ㡲࡛࠶ࡾࠊࡑࡢࡓࡵᡃࠎࡢయࡣయᾮࡢᾐ㏱ᅽࢆ┘どࡍࡿ௙⤌ࡳࢆഛ࠼࡚
࠸ࡲࡍࠋ⬺Ỉ➼࡟ࡼࡾయᾮࡢᾐ㏱ᅽࡀୖ᪼ࡋࡓሙྜ࡟ࡣࠊཱྀῬឤࢆឤࡌ࡚㣧Ỉࡍࡿ࡜࡜ࡶ࡟ࠊ⬻ୗᆶయ࠿ࡽᢠ฼ᒀ࣍ࣝࣔࣥ㸦ࣂࢯࣉࣞࢵࢩࣥ㸧ࡀ⾑୰࡟ᨺฟࡉࢀࠊ⭈⮚࡟࠾࠸࡚ᒀ㔞ࢆῶᑡࡉࡏࡿ➼ࡢ཯ᛂࡀฟࡿࡇ࡜࡟࡞ࡾࡲࡍࠋ7539 ࡣࠊࢺ࢘࢞ࣛࢩࡢ㎞࿡ᡂศ㸦࢝ࣉࢧ࢖ࢩࣥ㸧ࡸ⇕ࠊ㓟࡞࡝ࡢᾐᐖ่⃭࡟ᛂ⟅ࡋ࡚㛤ཱྀࡍࡿࢳࣕࣥࢿࣝศᏊ࡜ࡋ࡚᭷ྡ࡛ࡍࡀࠊ7539 㑇ఏᏊḞᦆ࣐࢘ࢫࡀయᾮᾐ㏱ᅽࡢไᚚ࡟࠾࠸
࡚␗ᖖࢆ♧ࡍࡇ࡜࠿ࡽࠊᾐ㏱ᅽࢭࣥࢧ࣮ศᏊࡢೃ⿵࡛࠶ࡿ࡜ࡶゝࢃࢀ࡚࠸ࡲࡋࡓࠋ ௒ᅇࠊᇶ♏⏕≀Ꮫ◊✲ᡤ࣭⤫ྜ⚄⤒⏕≀Ꮫ◊✲㒊㛛ࡢ㔝⏣ᫀᬕᩍᤵࡽࡣࠊ7539 ࢳࣕࣥࢿࣝࢆⓎ⌧ࡍࡿ⣽⬊ᰴࢆ⏝࠸࡚ࠊ7539 ࡀయ

௜㏆ࡢ

ᗘ࡛ᾐ㏱ᅽឤཷᛶࢆ♧ࡍࡇ࡜ࢆ☜ㄆࡍࡿ࡜ඹ࡟ࠊࡑࡢᛂ⟅ࡀ࢝ࣉࢧ࢖ࢩࣥࡸ㓟࡟ࡼࡗ࡚ࡶ┦஌ⓗ࡟ቑᙉࡉࢀࡿࡇ࡜ࢆぢฟࡋࡲࡋࡓࠋ௒ᅇࡢᡂᯝࡣࠊᡃࠎࡢయࡀయᾮ
ᜏᖖᛶࢆ⥔ᣢࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡍࡿୖ࡛㔜せ࡞ᡭ᥃࠿ࡾ࡜࡞ࡿࡶࡢ࡛ࡍࠋࡲࡓࠊᚋ㏙ࡢࡼ࠺࡟ࠊ⢾ᒀ⑓ᝈ⪅ࡢከ㣧⾜ືࡸࠊ③ࡳࡢឤ▱ᶵᵓࡢ⌮ゎ࡟ࡶᙺ❧ࡘࡶࡢ࡛ࡍࠋ◊✲ࡢヲ⣽ࡣ⡿ᅜࡢ⛉Ꮫ㞧ㄅࣉࣟ
ࢫ࣡ࣥ 3/R621( ㄅ࡟Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ᪥หᕤᴗ᪂⪺  㠃ࠊ ⛉Ꮫ᪂⪺  㠃

− 202 −

 ᖺ  ᭶  ᪥⏕Ṫ⣽⬊ࡢᛶูࢆỴࡵࡿ㑇ఏᏊࡢⓎぢ+DVKL\DPD.+D\DVKL<DQG.RED\DVKL6  'URVRSKLOD6H[OHWKDOJHQHLQLWLDWHVIHPDOHGHYHORSPHQWLQJHUPOLQHSURJHQLWRUV6FLHQFH
 ⮬↛⛉Ꮫ◊✲ᶵᵓᒸᓮ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮㸦ᒸᓮ⤫ྜࣂ࢖࢜㸧࣭ᇶ♏⏕≀Ꮫ◊✲ᡤࡢᶫᒣ୍ဢ◊✲ဨࠊᯘⰋᶞຓᩍ࠾ࡼࡧᑠᯘᝅᩍᤵࡣࠊࢩࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓ◊✲࡟ࡼࡾࠊ⏕Ṫ⣽⬊ࡢ࣓ࢫ໬ࡢ㘽ࢆᥱࡿ㑇ఏᏊࢆⓎぢࡋࡲࡋࡓࠋ⏕Ṫ⣽⬊㸦ጞཎ⏕Ṫ⣽⬊㸧ࡣࠊ⏕Ṫᕢ࠿ࡽ㞳ࢀࡓሙᡤ࡟ᙧᡂࡉࢀࠊ
⏕Ṫᕢ࡬࡜⛣ືࡋࡓᚋ࡟ࠊ༸࠶ࡿ࠸ࡣ⢭Ꮚ࡟ศ໬ࡋࡲࡍࠋጞཎ⏕Ṫ⣽⬊ࡀ༸࡟ศ໬ࡍࡿ࠿ࠊࡑࢀ࡜ࡶ⢭Ꮚ࡟ศ໬ࡍࡿ࠿࡜࠸࠺ᛶูࡣࠊయ⣽⬊࡛ᵓᡂࡉࢀࡿ⏕Ṫᕢࡢᛶ࡟౫Ꮡࡍࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡲࡋࡓࠋࡇࡢ
⪃࠼᪉ࢆࡶ࡜࡟ࡍࡿ࡜ࠊ⏕Ṫᕢ࡬࡜⛣ື㏵୰࡟࠶ࡿጞཎ⏕Ṫ⣽⬊ࡣࠊᛶࡢ༊ูࡀ࡞࠸࡜࠸࠺ࡇ࡜࡟࡞ࡾ
ࡲࡍࠋࡋ࠿ࡋࠊ◊✲ࢢ࣮ࣝࣉࡣࠊࡇࡢ⛣ື୰ࡢጞཎ⏕Ṫ⣽⬊࡟ᛶᕪࡀ࠶ࡿࡇ࡜ࢆⓎぢࡋࡲࡋࡓࠋ6[O㸦࢚ࢫ࣭࢚ࢵࢡࢫ࣭࢚ࣝ㸧࡜࿧ࡤࢀࡿ㑇ఏᏊࡀࠊ࣓ࢫࡢጞཎ⏕Ṫ⣽⬊ࡢࡳ࡛άᛶ໬ࡉࢀ࡚࠸ࡓࡢ࡛ࡍࠋ࣓ࢫ
ࡢጞཎ⏕Ṫ⣽⬊࡟࠾࠸࡚ࠊࡇࡢ 6[O 㑇ఏᏊࡢാࡁࢆᢚไࡍࡿ࡜ࠊࡑࡢጞཎ⏕Ṫ⣽⬊࠿ࡽࡣ༸ࡀసࡽࢀ࡞
ࡃ࡞ࡾࡲࡋࡓࠋࡉࡽ࡟ࠊᮏ᮶ 6[O 㑇ఏᏊࢆⓎ⌧ࡋ࡞࠸࢜ࢫጞཎ⏕Ṫ⣽⬊࡛ 6[O 㑇ఏᏊࢆᙉไⓗ࡟άᛶ໬ࡋࠊ࣓ࢫಶయࡢ⏕Ṫᕢ࡟⛣᳜ࡍࡿ࡜༸࡟ศ໬ࡍࡿࡇ࡜ࡀࢃ࠿ࡾࠊ௚ࡢᐇ㦂⤖ᯝ࡜ేࡏ࡚ 6[O 㑇ఏᏊࡀጞཎ⏕Ṫ⣽⬊ࡢ࣓ࢫ໬ࡢ㘽ࢆᥱࡿ㑇ఏᏊ࡛࠶ࡿ࡜⤖ㄽ࡛ࡁࡲࡋࡓࠋ ࡇࡢᡂᯝࡣࠊ⡿ᅜ⛉Ꮫ㞧ㄅࠕ6FLHQFHࠖࡢ㟁Ꮚ∧࡟࡚㸵᭶㸶᪥㸦㔠㸧࡟Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ᮅ᪥᪂⪺  㠃ࠊ ୰᪥᪂⪺  㠃ࠊ ẖ᪥᪂⪺  㠃ࠊ ᪥ᮏ⤒῭᪂⪺ 㠃ࠊ ᪥หᕤᴗ᪂⪺  㠃ࠊ ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ ᮾᾏឡ▱᪂⪺  㠃ࠊ ㄞ኎᪂⪺  㠃ࠊ :HE6FLHQFHࠊ ⛉Ꮫ᪂⪺  㠃

− 203 −

 ᖺ  ᭶  ᪥࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢࢱࣥࣃࢡ㉁㍺㏦࡟㛵ࢃࡿ᳜≀≉␗ⓗ࡞᪂つᅉᏊࢆⓎぢ
Goto, S., Mano, S., Nakamori C., and Nishimura, M. (2011). Arabidopsis ABERRANTPEROXISOME MORPHOLOGY 9 is a peroxin that recruits the PEX1-PEX6 complex toperoxisomes. Plant Cell 23, 1573-1587.
 ᳜≀⣽⬊ࡢ୰࡟ࡣࠊ᰾ࡸⴥ⥳య࡞࡝ᵝࠎ࡞࢜ࣝ࢞ࢿࣛ㸦⣽⬊ෆᑠჾᐁ㸧ࡀ࠶ࡾࡲࡍࡀࠊࡇࢀࡽࡢ࠺ࡕࠊ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ᳜≀ࡢⓎⱆࡸගྜᡂࠊ✀Ꮚᙧᡂ࡟㛵ࢃࡾࠊ᳜≀⏕㛗࡟ᚲ㡲࡞࢜ࣝ࢞ࢿ࡛ࣛࡍࠋࡋ࠿
ࡋࠊ᳜≀⣽⬊࡟࠾ࡅࡿ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂࡢ௙⤌ࡳࡣ࠶ࡲࡾ᫂ࡽ࠿࡟ࡉࢀ࡚࠸ࡲࡏࢇ࡛ࡋࡓࠋ௒ᅇࠊ
ᇶ♏⏕≀Ꮫ◊✲ᡤ࣭㧗ḟ⣽⬊ᶵᵓ◊✲㒊㛛ࡢᚋ⸨ᚿ㔝኱Ꮫ㝔⏕㸦⥲ྜ◊✲኱Ꮫ㝔኱Ꮫ㸧ࠊ┿㔝ᫀ஧ຓᩍ࠾ࡼࡧすᮧᖿኵᩍᤵࡽࡣࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢࢱࣥࣃࢡ㉁㍺㏦࡟㛵ࢃࡿ᳜≀≉␗ⓗ࡞᪂つᅉᏊࢆⓎぢࡋࡲࡋࡓࠋ ◊✲ࢢ࣮ࣝࣉࡣࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ⥳Ⰽ⺯ගࢱࣥࣃࢡ㉁㸦*)3㸧࡟ࡼࡗ࡚ྍど໬ࡉࢀࡓ᳜≀యࢆ⏝࠸࡚ࠊ㑇ఏᏊࢆࣛࣥࢲ࣒࡟ቯࡍᐇ㦂ࢆ⾜࠸ࠊࢱࣥࣃࢡ㉁㍺㏦࣓࢝ࢽࢬ࣒࡟㛵ࢃࡿ㑇ఏᏊࠊࠕ$3(0ࠖ㸦$3(0ࡣ DEHUUDQWSHUR[LVRPHPRUSKRORJ\ ࡢ␎࡛࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ␗ᖖࡢព㸧ࢆⓎぢࡋࡲࡋࡓࠋ$3(0 ࡀാ࠿࡞࠸࡜ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡬ࡢࢱࣥࣃࢡ㉁㍺㏦ࡀ⁫ࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᶵ⬟ࢆኻ࠸ࡲࡍࠋࡉࡽ࡟ࠊ
࢚ࢿࣝࢠ࣮※࡛࠶ࡿࢩࣙ⢾ࢆேⅭⓗ࡟୚࠼࡚ࡸࡽ࡞࠸࡜Ⓨⱆ࡛ࡁ࡞࠿ࡗࡓࡾࠊⓎⱆ࡛ࡁ࡚ࡶ᳜≀యࡀᑠࡉࡃ࡞ࡗࡓࡾ࡜ࠊ᳜≀ࡢ⏕⫱࡟ࡶ㔜኱࡞ᙳ㡪ࡀࡳࡽࢀࠊ$3(0 ࡣ᳜≀ࡢ⏕࿨⥔ᣢ࡟㔜せ࡞㑇ఏᏊ࡛࠶ࡿ
ࡇ࡜ࡀࢃ࠿ࡾࡲࡋࡓ ࡇࡢᡂᯝࡣࠊᅜ㝿᳜≀Ꮫᑓ㛛ㄅ7KH3ODQW&HOO ࡢ㟁Ꮚ∧࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ⛉Ꮫ᪂⪺  㠃ࠊ ᪥หᕤᴗ᪂⪺  㠃− 204 −

 ᖺ  ᭶  ᪥ࢩࢲࢤࣀ࣒ࡢゎㄞ㹼㝣ୖ᳜≀㑇ఏᏊࡢண᝿እࡢከᵝᛶࢆⓎぢ㸸㑇ఏᏊ㈨※࡜ࡋ࡚᭷⏝㹼Banks, J.A., Nishiyama, T., Hasebe, M., Bowman, J.L., Gribskov, M., dePamphilis, C.,
Albert, V.A., Aono, N., Aoyama, T., Ambrose, B.A., et al. (2011). The Selaginella genome
identifies genetic changes associated with the evolution of vascular plants. Science 332,
960-963.
 ኱Ꮫඹྠ฼⏝ᶵ㛵࡛࠶ࡿᇶ♏⏕≀Ꮫ◊✲ᡤࡢ㛗㇂㒊ගὈᩍᤵࠊ㔠ἑ኱ᏛᏛ㝿⛉Ꮫᐇ㦂ࢭࣥࢱ࣮㑇ఏᏊ◊✲᪋タࡢすᒣᬛ᫂ຓᩍࡽࡣࠊᅜෆ㸳኱Ꮫ࠾ࡼࡧᅜእ㸷ࣧᅜ࡟ࡼࡿᅜ㝿ඹྠ◊✲ࢳ࣮࣒࡜ඹྠ࡛ࠊࢩࢲ
᳜≀ࡢ୍✀࡛࠶ࡿ࢖ࢾ࢝ࢱࣄࣂࡢࢤࣀ࣒ゎㄞ࡟ᡂຌࡋࡲࡋࡓࠋ ᚑ᮶ࠊ㝣ୖ᳜≀ࡢ୰࡛᭱ࡶ」㞧࡞ᙧࢆᣢࡗࡓ⿕Ꮚ᳜≀࡜ࠊ᭱ࡶ༢⣧࡞ᙧࢆᣢࡗࡓࢥࢣ᳜≀ࡢࢤࣀ࣒ࡣ
ゎㄞࡉࢀ࡚࠸ࡲࡋࡓࡀࠊ୧⪅ࡢ୰㛫࡟఩⨨ࡍࡿࢩࢲ᳜≀ࡣࢤࣀ࣒ࡢ኱ࡁࡉࡀ኱ࡁࡃࠊࢤࣀ࣒ゎㄞࡀᅔ㞴࡛ࡋࡓࠋ௒ᅇࠊࢤࣀ࣒ࡢ኱ࡁࡉࡀᴟࡵ࡚ᑠࡉ࠸࢖ࢾ࢝ࢱࣄࣂࢆ⏝࠸ࡿࡇ࡜࡛ࠊࢩࢲ᳜≀ࡢࢤࣀ࣒ゎㄞ࡟ึࡵ࡚ᡂຌࡋࠊࢩࢲ᳜≀࡜ࢥࢣ᳜≀ࠊ⿕Ꮚ᳜≀ࡢࢤࣀ࣒ࢆẚ㍑ゎᯒࡋࡓ⤖ᯝࠊ㝣ୖ᳜≀ࡀඹ㏻࡟ᣢࡘ㑇ఏᏊࡀ᫂ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡲࡓࠊⰼࡢဏࡃ᳜≀㸦⿕Ꮚ᳜≀㸧࡜ⰼࡢဏ࠿࡞࠸᳜≀㸦ࢩࢲ᳜≀㸧࡜ࡢ㛫࡛ࠊ㑇ఏᏊࡢⓎ⌧ࢆไᚚࡍࡿ㑇ఏᏊ㸦㌿෗ᅉᏊ㸧ࡢᩘࡀቑ࠼࡚࠾ࡾࠊࡇࢀࡀ༢⣧࡞ᙧࢆᣢࡗࡓ᳜≀࠿ࡽ」㞧࡞ᙧࢆᣢࡗࡓ᳜≀࡬ࡢ㐍໬ࢆᘬࡁ㉳ࡇࡋࡓྍ⬟ᛶࡀ㧗࠸ࡇ࡜ࡶศ࠿ࡾࡲࡋࡓࠋࡇࢀࡲ࡛ࠊ᳜≀ࡣື≀࡜ẚ࡭ࡿ࡜஫࠸࡟ᙧࡀఝ࡚࠸ࡿࡇ࡜࠿ࡽࠊື≀ࡼࡾࡶ㑇ఏᏊࡢ㐍໬ࡢ⛬ᗘࡀࡎࡗ࡜ᑡ࡞࠸ࡔࢁ࠺࡜ᛮ
ࢃࢀ࡚ࡁࡲࡋࡓࡀࠊ௒ᅇࡢ◊✲⤖ᯝࡼࡾࠊ㝣ୖ᳜≀ࡢࢤࣀ࣒ࡣື≀ࡼࡾࡶ኱ࡁࡃኚ໬ࡋ࡚࠸ࡿࡇ࡜ࡀ᫂
ࡽ࠿࡟࡞ࡾࡲࡋࡓࠋࡉࡽ࡟ࠊ⑓Ẽࡸᐖ⹸࡟㣗࡭ࡽࢀ࡞࠸ࡼ࠺࡟ࡋࡓࡾⰼ⢊ࢆ㐠ࡪ᪻⹸ࢆᘬࡁᐤࡏࡓࡾࡍ
ࡿാࡁࢆᣢࡘ஧ḟ௦ㅰ⏘≀ࡸࠊ᳜≀ࡢ⏕⫱࡟ᚲせ࡞᳜≀࣍ࣝࣔࣥࡢྜᡂ㓝⣲㑇ఏᏊ࡞࡝ࡣࠊ⿕Ꮚ᳜≀࣭ࢩࢲ᳜≀࣭ࢥࢣ᳜≀࡛ࡑࢀࡒࢀ⊂⮬࡟ᩘࢆቑࡸࡋࡓࡾῶࡽࡋࡓࡾࡋ࡚ከᵝᛶࢆ⏘ࡳฟࡋ࡚࠸ࡿࡇ࡜ࡶศ
࠿ࡾࡲࡋࡓࠋ ᮏ◊✲ᡂᯝࡣࠊ㸰㸮㸯㸯ᖺ㸳᭶㸳᪥㸦⡿ᅜᮾ㒊᫬㛫㸧࡟⡿ᅜ⛉Ꮫ㞧ㄅࠕ㹑㹡㹧㹣㹬㹡㹣ࠖࡢ࢜ࣥࣛ࢖
ࣥ㏿ሗ∧࡛බ㛤ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ୰᪥᪂⪺  㠃ࠊ ᪥ᮏ⤒῭᪂⪺  㠃ࠊ ᪥หᕤᴗ᪂⪺  㠃ࠊ ẖ᪥᪂⪺㸦▼ᕝ㸧  㠃ࠊ :HEඹྠ㏻ಙࠊ :HE᫬஦㏻ಙࠊ :HE<$+22ࢽ࣮ࣗࢫࠊ ⛉Ꮫ᪂⪺  㠃ࠊ ᮅ᪥᪂⪺  㠃− 205 −

 ᖺ  ᭶  ᪥࣑࢜࢜ࢪࣥࢥࡢᛶỴᐃ㑇ఏᏊࡢⓎぢ.DWR < .RED\DVKL . :DWDQDEH + DQG ,JXFKL 7   (QYLURQPHQWDO VH[GHWHUPLQDWLRQ LQ WKH EUDQFKLRSRG FUXVWDFHDQ 'DSKQLD PDJQD 'HHS FRQVHUYDWLRQ RI D
GRXEOHVH[JHQHLQWKHVH[GHWHUPLQLQJSDWKZD\3/R6*HQHWLFVH ᒸᓮ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮࣭ᇶ♏⏕≀Ꮫ◊✲ᡤศᏊ⎔ቃ⏕≀Ꮫ◊✲㒊㛛ࡢ஭ཱྀὈἨᩍᤵࡽ࡜
኱㜰኱Ꮫࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ࣑࢜࢜ࢪࣥࢥࡢ࢜ࢫࢆỴᐃࡍࡿ௙⤌ࡳࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋ ◊✲ࢢ࣮ࣝࣉࡣࠊ࣓ࢫ࡜࢜ࢫ࡛ാ࠸࡚࠸ࡿ㑇ఏᏊࡢ㐪࠸ࢆẚ㍑ࡋࠊ࢜ࢫࡔࡅ࡛ᙉࡃാ࠸࡚࠸ࡿ㑇ఏᏊࠊ
ࠕGRXEOHVH[ ࢲࣈࣝࢭࢵࢡࢫ㸯 ࠖࢆⓎぢࡋࡲࡋࡓࠋ࣑ࢪࣥࢥࡢ༸ෆ࡛㑇ఏᏊࡢാࡁࢆṆࡵࡿᡭἲ㸦࣑ࢪࣥࢥ࡟࠾ࡅࡿ 51$ ᖸ΅ἲ㸧ࢆ᪂ࡓ࡟㛤Ⓨࡋࠊࡇࡢ᪉ἲࢆ⏝࠸࡚ࠊࢲࣈࣝࢭࢵࢡࢫ㸯㑇ఏᏊࡢാࡁࢆṆࡵࡿ࡜ࠊ࢜ࢫ࡟࡞ࡿࡣࡎࡢ༸࠿ࡽ⏕ࡲࢀࡓ࣑ࢪࣥࢥࡣ࣓ࢫࡢᙧែࢆ♧ࡋࡲࡋࡓࠋࡲࡓࠊࡇࡢ㑇ఏᏊࢆ࣓ࢫ࡟࡞ࡿ༸࡟ὀධࡍࡿ࡜࢜ࢫࡢᙧែࢆ♧ࡋࡲࡋࡓࠋࡇࢀࡽࡢ⤖ᯝࡼࡾࠊ஭ཱྀࡽࡣࠊࢲࣈࣝࢭࢵࢡࢫ㸯㑇ఏᏊࡢാࡁ᪉ࡢ㐪࠸ࡀࠊ࣑࢜࢜ࢪࣥࢥࡢ࢜ࢫ࡜࣓ࢫࢆỴࡵ࡚࠸ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓ㸦ࢲࣈࣝࢭࢵ
ࢡࢫ㸯ࡀാࡃ࡜࢜ࢫ࡟ࠊࢲࣈࣝࢭࢵࢡࢫ㸯ࡀാ࠿࡞࠸࡜࣓ࢫ࡟࡞ࡿ㸧ࠋࡇࢀࡣࠊ⎔ቃᛶᛶỴᐃ࡟࠾࠸࡚ࠊ
ලయⓗ࡟ᛶࢆỴࡵ࡚࠸ࡿ㑇ఏᏊࡀ᫂ࡽ࠿࡟࡞ࡗࡓୡ⏺࡛ึࡵ࡚ࡢ౛࡛ࡍࠋ ௨ୖࡢᡂᯝࡣࠊ㑇ఏᏛᑓ㛛ㄅ 3/R6*HQHWLFV㸦ࣉࣟࢫࢪ࢙ࢿࢸ࢖ࢵࢡࢫ㸧㸰㸮㸯㸯ᖺ㸱᭶ྕ࡟࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ⛉Ꮫ᪂⪺  㠃ࠊ ᪥หᕤᴗ᪂⪺  㠃− 206 −

 ᖺ  ᭶  ᪥࡚ࢇ࠿ࢇⓎస࡟㛵ࢃࡿ㑇ఏᏊࡢྠᐃ

Tao, H., Manak, J.R., Sowers, L., Mei. X., Kiyonari, H., Abe, T., Dahdaleh, N.S., Yang,
T., Wu, S., Chen, S., Fox, M.H., Gurnett, C., Montine, T., Bird, T., Shaffer, L.G., Rosenfeld,
J.A., McConnell, J., Madan-Khetarpal, S., Berry-Kravis, E., Giesbach, H., Saneto, R.P.,
Scott, M.P., Antic, D., Reed, J., Boland, R., Axelrod, J.D., Lehesjoki, A.-E., Fritzsch, B.,
Slusarski, D.C., Wemmie, J., Ueno, N., and Bassuk, A.G. (2011). Mutations in prickle
orthologs cause seizures in flies, mice, and humans. Am. J. Human Genetics 88, 138-149.
 ᇶ♏⏕≀Ꮫ◊✲ᡤࡢୖ㔝┤ேᩍᤵࠊ⌮໬Ꮫ◊✲ᡤⓎ⏕෌⏕⛉Ꮫ⥲ྜ◊✲ࢭࣥࢱ࣮ࠊ࠾ࡼࡧ࢔࢖࢜࣡኱
Ꮫ་Ꮫ㒊ࡢ %DVVXN ༤ኈࡽࡢ◊✲ࢢ࣮ࣝࣉࡣࠊ⣽⬊ࡢᴟᛶ㸦ᙧࡸᶵ⬟ⓗ࡞㠀ᑐ⛠ᛶ㸧ࢆỴࡵಶయࡢⓎ⏕࡟ࡶ㔜せ࡞ᙺ๭ࢆᢸ࠺ᅉᏊࡢࡦ࡜ࡘ 3ULFNOH㸦ࣉࣜࢵࢡࣝ㸧㑇ఏᏊࡢኚ␗ࡀࠊ࡚ࢇ࠿ࢇⓎసࡢ࠾ࡇࡾࡸࡍ
ࡉ࡟㛵ࢃࡿࡇ࡜ࢆ♧ࡋࡲࡋࡓࠋ◊✲ࢢ࣮ࣝࣉࡣࠊ3ULFNOH 㑇ఏᏊࡢᶵ⬟ࡀపୗࡋࡓ࣐࢘ࢫ࡛ࡣࠊṇᖖ࣐࢘ࢫ࡟ẚ࡭࡚Ⓨసࢆ㉳ࡇࡋࡸࡍ࠸ࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡲࡋࡓࠋࡲࡓࠊᮏ◊✲࡛ࡣ࣐࢘ࢫࡔࡅ࡛࡞ࡃࠊ㨶ࡸࢪࣙ࢘ࢪࣙ࢘ࣂ࢚ࢆ⏝࠸ࡓᐇ㦂࡟࠾࠸࡚ࡶࠊ3ULFNOH 㑇ఏᏊࡢᶵ⬟ࡢపୗࡀ⚄⤒άືࡢ␗ᖖࢆᘬࡁ㉳ࡇࡍࡇ࡜ࢆ♧ࡋࡲࡋࡓࠋࡇࢀࡣࠊ3ULFNOH 㑇ఏᏊࡀࠊᖜᗈ࠸⏕≀✀࡟࠾࠸࡚ࠊ୰ᯡ⚄⤒࡛୺せ࡞ᶵ⬟ࢆᣢࡘࡇ࡜ࢆ♧၀ࡍࡿࡶࡢ࡛ࡍࠋ ࡇࡢᡂᯝࡣࠊ㸰᭶㸯㸯᪥࡟⡿ᅜே㢮㑇ఏᏛ఍ㄅ7KH$PHULFDQ-RXUQDORI+XPDQ*HQHWLFV ࡛Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 ᪥⤒⏘ᴗ᪂⪺  㠃ࠊ ⛉Ꮫ᪂⪺  㠃

− 207 −

 ᖺ  ᭶  ᪥ᚰ⮚ࡸື⬦⣔ࠊ⬚⭢ࠊ๪⏥≧⭢࡞࡝ࡢᙧᡂ࡟୙ྍḞ࡞㑇ఏᏊࢆ᪂ࡓ࡟Ⓨぢ
Okubo, T., Kawamura, A., Takahashi, J., Yagi, H., Morishima, M., Matsuoka, R., andTakada, S. (2011). Ripply3, a Tbx1 repressor, is required for development of thepharyngeal apparatus and its derivatives in mice. Development 138, 339-348 ᒸᓮ⤫ྜࣂ࢖࢜ࢧ࢖࢚ࣥࢫࢭࣥࢱ࣮࣭ᇶ♏⏕≀Ꮫ◊✲ᡤࡢ኱ஂಖ┤ຓᩍ࠾ࡼࡧ㧗⏣ៅ἞ᩍᤵࡽࡢࢢࣝ
࣮ࣉࡣࠊᮾிዪᏊ་኱࡜ࡢඹྠ◊✲࡟ࡼࡾࠊᚰ⮚ࡸ኱ື⬦ࠊ⬚⭢ࠊ๪⏥≧⭢࡞࡝ࡢᙧᡂ࡟୙ྍḞ࡞㑇ఏᏊࢆࠊ࣐࢘ࢫࢆ⏝࠸ࡓᐇ㦂࡟ࡼࡾ᪂ࡓ࡟Ⓨぢࡋࡲࡋࡓࠋࣄࢺࡸ࣐࢘ࢫ࡞࡝ࡢ⬨᳝ື≀࡛ࡣࠊᚰ⮚ࡢ୍㒊࡛࠶ࡿὶฟ㊰ࡸࡑࢀ࡟⧅ࡀࡿ኱ື⬦⣔ࠊ࡞ࡽࡧ࡟⬚⭢ࡸ๪⏥≧⭢࡞࡝ࡢဗ㢌㒊࡟ᙧᡂࡉࢀࡿჾᐁࡢ୍㒊ࡣࠊ⫾ඣࡢ᫬ᮇ࡟ࠊဗ㢌ᘪ࡜࿧ࡤࢀࡿ⤌⧊࠿ࡽⓎ㐩ࡋࡲࡍࠋဗ㢌ᘪࡸࡑࡇ࠿ࡽⓎ㐩ࡍࡿჾᐁࡢᙧᡂ࡟ࡣࠊ
7E[ ࡜࿧ࡤࢀࡿ㑇ఏᏊࡀ㔜せ࡛࠶ࡾࠊࡇࡢ㑇ఏᏊࡢ␗ᖖ࡟ࡼࡾࢹ࢕ࢪ࣮ࣙࢪ⑕ೃ⩌࡜࠸࠺ඛኳᛶࡢከ⮚ჾ⑌ᝈࡀᘬࡁ㉳ࡇࡉࢀࡿࡇ࡜ࡀࡍ࡛࡟▱ࡽࢀ࡚࠸ࡲࡍࠋ௒ᅇࠊ኱ஂಖຓᩍࡽࡣࠊ5LSSO\㸦ࣜࣉ࣮ࣜ㸱㸧࡜࿧ࡤࢀࡿ㑇ఏᏊࡢゎᯒࢆ⾜࠸ࠊဗ㢌ᘪ࡞ࡽࡧ࡟ᚰ⮚ࡸື⬦⣔ࠊ⬚⭢ࠊ๪⏥≧⭢࡞࡝ࡢჾᐁࡀṇᖖ࡟ᙧᡂࡉࢀࡿࡓࡵ࡟ࡣࠊ5LSSO\ 㑇ఏᏊࡀ୙ྍḞ࡛࠶ࡿࡇ࡜ࢆࠊ࣐࢘ࢫࢆ⏝࠸ࡓᐇ㦂࡟ࡼࡾ᫂ࡽ࠿࡟ࡋࡲࡋ
ࡓࠋࡉࡽ࡟ࠊ5LSSO\ ࡀ 7E[ ࡢᶵ⬟ࢆㄪ⠇ࡍࡿࡇ࡜ࡶྠ᫬࡟♧ࡋࡲࡋࡓࠋࡇࡢ⤖ᯝࡣࠊᚰ⮚⾑⟶⣔ࡸ⬚⭢ࠊ๪⏥≧⭢࡞࡝ࡀᙧᡂࡉࢀࡿࡋࡃࡳࡸࠊࢹ࢕ࢪ࣮ࣙࢪ⑕ೃ⩌ࡢࡼ࠺࡞ඛኳᛶࡢከ⮚ჾ⑌ᝈࡢⓎ⑕࣓࢝ࢽࢬ࣒ࡢゎ᫂࡟኱ࡁࡃ㈉⊩ࡍࡿࡶࡢ࡜ᮇᚅࡉࢀࡲࡍࠋࡇࡢ◊✲ࡢᡂᯝࡣࠊ㸯㸰᭶㸰㸰᪥࡟Ⓨ⏕⏕≀Ꮫᑓ㛛ㄅ 'HYHORSPHQW㸦㟁Ꮚ∧㸧࡟࠾࠸࡚Ⓨ⾲ࡉࢀࡲࡋࡓࠋ
᪂⪺ሗ㐨㸸 1HZV:HEࠊ ୰᪥᪂⪺㸦ኤ㸧  㠃ࠊ ᪥⤒⏘ᴗ᪂⪺  㠃



− 208 −

ᇶ♏⏕≀Ꮫ◊✲ᡤ Ⅼ᳨ホ౯ጤဨ఍
ᒣᮏṇᖾ  ጤဨ㛗



ୖ㔝┤ே



㔝⏣ᫀᬕ

      ᑠᯘ ᝅ


ྜྷ⏣ᯇ⏕



஭ཱྀὈἨ



ᕝཱྀṇ௦ྖ      ᒣ᳃ဴ㞝


㧗⏣ៅ἞



⸨᳃ಇᙪ



ඣ⋢㝯἞



ᑠᯘᘯᏊ


እ㒊Ⅼ᳨ホ౯఍㆟ ᡤෆฟᖍ⪅


ᒣᮏṇᖾ



ୖ㔝┤ே



㔝⏣ᫀᬕ



ᑠᯘ ᝅ      ྜྷ⏣ᯇ⏕      すᮧᖿኵ


ඣ⋢㝯἞


እ㒊Ⅼ᳨ホ౯ሗ࿌᭩ ไస


ඣ⋢㝯἞



ᆏ⚄┿⌮



 

㸦ᩗ⛠␎㸧

− 209 −

− 210 −− 211 −大学共同利用機関法人
自然科学研究機構

基礎生物学研究所

外部点検評価報告書
発行日

平成２６年７月

発行者

大学共同利用機関法人 自然科学研究機構
基礎生物学研究所
点検評価委員会〒444−8585

愛知県岡崎市明大寺町字西郷中38番地