Michael Strong, Ph.D.

Michael Strong, PhD
Assistant Professor
National Jewish HealthIntegrated Center for Genes, Environment, and Health
Smith Building, Room A651
1400 Jackson StreetDenver, CO 80206
303-270-2782
StrongM@NJHealth.org
www.stronglab.org

FACULTY
I am an Assistant Professor in the Integrated Center for Genes, Environment, and Health, at National Jewish Health.
Research interests include genomics, systems biology, structural informatics, and the development of computational
methods to better examine the interplay among humans, human pathogens, and environmental factors.
http://www.nationaljewish.org/professionals/research/programs-depts/genetics-therapeutics/labs/michael-strong/
I am also a core faculty member of the Computational Bioscience Program at the University of Colorado, Denver,
School of Medicine. http://compbio.ucdenver.edu/pages/corefaculty.html

POSTDOCTORALHarvard Medical School - I conducted my postdoctoral work in George M. Church’s lab in the Department of Genetics atHarvard Medical School. Research interests include genomics, biochemistry, systems biology, and synthetic biology.
(Recipient of a Jane Coffin Childs Foundation Research Grant).

EDUCATION
Ph.D. in Molecular Biology, University of California, Los Angeles. 2005. Graduate Advisor – David Eisenberg. My
research focused on identifying the modular nature of genome-wide protein networks, and developing biochemical tools toidentify protein-protein interactions. Research interests include genomics, protein biochemistry, molecular biology,bioinformatics, and structural biology. (recipient of NIH Cell and Molecular Biology Training Grant)
B.S. Microbiology, concentration in Genetic Engineering. University of California, Santa Barbara. (recipient of HHMI
undergraduate research grant).

PUBLICATIONS
Network and Matrix Analysis of the Respiratory Disease Interactome. Benjamin Garcia, Gargi Datta, Gregory P Cosgrove,
Michael Strong. BMC Systems Biology, 8:34 (2014).
A Minimum Variance Method for Genome-wide Data-driven Normalization of qRT-PCR Expression Data. Benjamin
Garcia, Nicholas D Walter, Gregory Dolganov, Marc Coram, J. Lucian Davis, Gary K. Schoolnik, Michael Strong.
Analytical Biochemistry, 458:11-13 (2014).
High Relatedness among Mycobacterium abscessus subsp. massiliense Strains from Geographically Distant Outbreaks.
Hervé Tettelin, Rebecca M. Davidson, Sonia Agrawal, Moira L. Aitken, Shamira Shallom, Nabeeh A. Hasan, MichaelStrong, Vinicius Calado Nogueira de Moura, Mary Ann De Groote, Rafael S. Duarte, Erin Hine, Sushma Parankush, QiSu, Sean C. Daugherty, Claire M. Fraser, Barbara A. Brown-Elliott, Richard J. Wallace Jr., Steven M. Holland, Elizabeth
P. Sampaio, Kenneth N. Olivier, Mary Jackson, Adrian M. Zelazny. Emerging Infectious Diseases, 20:3 (2014).
HspX Vaccination and Role in Virulence in the Guinea Pig Model of Tuberculosis. Agatha E. Wieczorek, Jolynn L. Troudt,Phillip Knabenbauer, Jennifer Taylor, Rebecca L. Pavlicek, Russell Karls, Anne Hess, Rebecca M. Davidson, MichaelStrong, Helle Bielefeldt-Ohmann, Angelo A. Izzo, Karen M. Dobos. Pathogens and Disease, Feb 24 (2014).
Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global
outbreak strains. Rebecca M. Davidson, Nabeeh A. Hasan, Vinicius Calado Nogueira de Moura, Rafael Silva Duarte,
Mary Jackson, Michael Strong. Infection, Genetics and Evolution, S1567-1348(13)00353-5 (2013).

Michael Strong, Ph.D.
Genome sequence of an epidemic isolate of Mycobacterium abscessus subsp. bolletii from Rio de Janeiro, Brazil.
Rebecca M. Davidson, Paul R. Reynolds, Eveline Farias-Hesson, Rafael Silva Duarte, Mary Jackson, Michael Strong.
Genome Announcements, 1:e00617-13 (2013).
Galectin-9 functionally impairs natural killer (NK) cells in humans and mice.
Lucy Golden-Mason, Rachel McMahan, Michael Strong, Richard Reisdorph, Spencer Mahaffey, Brent Palmer, LinlingCheng, Caroline Kulesza, Mitsuomi Hirashima, Toshiro Niki, and Hugo Rosen. Journal of Virology, 87:4835-4845 (2013).
Translating basic science insight into public health action for MDR- and XDR-TB.
Walter, Nicholas; Strong, Michael; Belknap, Robert; Ordway, Diane; Daley, Charles L; Chan, Ed; Respirology. 17:772791 (2012).
Research, Collaboration, and Open Science using Web 2.0.
Kevin Shee*, Michael Strong*, Nicholas J. Guido, Robert Lue, George M. Church, Alain Viel. *Equal contribution, Journalof Microbiology and Biology Education, 11:2 p130-134, (2010).
Reducing Global Health Disparities through Research, Education, and International Collaboration .
Michael Strong. Center for Strategic and International Studies, Smart Global Health Policy Report p47-48 (2010).
Tuberculosis Drug Resistance Mutation Database .
Andreas Sandgren, Michael Strong, Preetika Mutukrishnan, Brian K. Weiner, George M. Church, Megan B. Murray.
PLoS Medicine 6:2 (2009).
Gem of an idea for a unique machine.
Michael Strong and George Church. Nature 447:112 (2007).
The Protein Network as a Tool for Finding Novel Drug Targets.
Michael Strong and David Eisenberg. Book Chapter in Systems Biological Approaches in Infectious Diseases. Edited byH.I.M Boshoff and C.E. Barry III, Birkhauser. Verlag Publishing. Progress in Drug Research, 64:191, 193-215 (2007).
Functional linkages can reveal protein complexes for structure determination.
Kim SM, Bowers PM, Pal D, Strong M, Terwilliger TC, Kaufmann M, Eisenberg D. Structure 15:1079-89 (2007).
Toward the Structural Genomics of Complexes: Crystal Structure of a PE/PPE protein complex from Mycobacterium
tuberculosis.
Michael Strong, Michael Sawaya, Shuishu Wang, Martin Philips, Duilio Cascio, and David Eisenberg. Proc. Natl. Acad.
Sci. U. S. A. 103:8060-8065 (2006).
Structural Proteomics and Computational Analysis of a Deadly Pathogen: Combating M. tuberculosis from Multiple Fronts.
Michael Strong and Celia Goulding. Book Chapter (Chapter 15) in Microbial Proteomics: Functional Biology of WholeOrganisms. Edited by Ian Humphrey-Smith and Michael Hecker. Wiley Publishing, Inc. Methods of Biochemical Analysis
49:245-69 (2006).
Unique Transcriptome Signature of Mycobacterium tuberculosis in Pulmonary Tuberculosis.
Helmy Rachman, Michael Strong, Timo Ulrichs, Leander Grode, Johannes Schuchhardt, Hans Mollenkopf, George A.
Kosmiadi, David Eisenberg, S.H.E. Kaufmann. Infection and Immunity 74:1233-1242. (2006).
Mycobacterium tuberculosis Gene Expression Profiling within the Context of Protein Networks.
Helmy Rachman*, Michael Strong*, Ulrich Schaible, Johannes Schuchhardt, Kristine Hagens, Hans Mollenkopf, DavidEisenberg, Stefan H.E. Kaufmann. *Equal Contribution. Microbes and Infection. 8:747-757 (2006).
A specific secretion system mediates PPE41 transport in pathogenic mycobacteria.
Abdallah M. Abdallah, Theo Verboom, Fredericke Hannes, Mohamad Safi, Michael Strong, David Eisenberg, Rene
Musters, Christina M.J.E. Vandenbroucke-Grauls, Ben J. Appelmelk, Joen Luirink4 and Wilbert Bitter. Molecular
Microbiology 62:667-79 (2006).
Scientists and Societies: Community Outreach.
Michael Strong. Nature. 434, 418. (2005).

Michael Strong, Ph.D.
Protein Nanomachines.
Michael Strong. PLoS Biology Mar, 2:E73. (2004).
A Web-Based Comparative Genomics Tutorial for Investigating Microbial Genomes.
Michael Strong, Duilio Cascio, and David Eisenberg. ASM Microbiology Education Journal 5: 30-35. (2004).
Genomes, Maps, and Modules: Navigating the M. tuberculosis Genome.
Michael Strong. UCLA Scientific Review 1: 28-32. (2004).
Visualization and Interpretation of Protein Networks in Mycobacterium tuberculosis Based on Hierarchical Clustering of
Genome-Wide Functional Linkage Maps.
Michael Strong, Thomas G. Graeber, Morgan Beeby, Matteo Pellegrini, Michael J. Thompson, Todd O. Yeates, andDavid Eisenberg. Nucleic Acids Research, 31: 7099-7109. (2003).
Inference of Protein Function and Protein Linkages in M. tuberculosis Based on Prokaryotic Genome Organization: A
Combined Computational Approach.
Michael Strong, Parag Mallick, Matteo Pellegrini, Michael J. Thompson, and David Eisenberg. Genome Biology 4:R59.1R59.16. (2003).
2'-Ribose-ferrocene oligonucleotides for electronic detection of nucleic acids.
Yu CJ, Wang H, Wan Y, Yowanto H, Kim JC, Donilon LH, Tao C, Strong M, Chong Y. Journal of Organic Chemistry66:2937-2942. (2001).
Uridine-Conjugated Ferrocene DNA Oligonucleotides: Unexpected Cyclization Reaction of the Uridine Base.
Yu, C. J.; Yowanto, H.; Wan, Y.; Meade, T. J.; Chong, Y.; Strong, M.; Donilon, L. H.; Kayyem, J. F.; Gozin, M.; Blackburn,G. F. Journal of the American Chemical Society. 122: 6767-6768. (2000).

WORK EXPERIENCE
California Institute of Technology. I worked at Caltech with Suzanna Horvath on projects involving DNA and RNA
synthesis applying phosphoramidite chemistry 1997-1998.
Clinical Microsensors (Motorola Biosciences). I worked with C.J. Yu on projects relating to the electronic detection ofnucleic acids, for use in medical diagnostics. 1998-1999

TEACHING AND MENTORING EXPERIENCE
University of California, Los Angeles.
*Teaching Assistant, Microbiology 101L, Microbiology Laboratory Course. (2002 and 2003)*I created a web-based genomics tutorial for the UCLA Macromolecular Structure class M253 (Fall 2003)*I taught a database and web design tutorial for the UCLA Molecular Biology Institute (Fall 2003)*I mentored middle school and high school students once a week at UCLA for about two years (2005-2006)
Harvard University*Teaching Fellow. I was a teaching fellow for the 2007 Harvard iGEM team (Summer 2007)
National Jewish Health
Volunteered to teach basic Genetics concepts to students at the Kunsberg School (Summer 2010).
Volunteer Guest Scientist at East High School, Denver, CO (2012 - 2014).
Volunteer Guest Lecturer at Colorado Academy, CO (2014).

Michael Strong, Ph.D.
University of Colorado, Denver
Faculty – Computational Bioscience 7711 (2 lectures each semester) –Fall 2010, 2011, 2013
Faculty– Biological Science Program Journal Club - Fall 2010
Faculty - Computational Bioscience 7712 (2 lectures each semester) – Spring 2011, 2012, 2014

AWARDS, Grants, and Fellowships
Eppley Foundation Research Grant, PI Strong (2013)
Boettcher Webb-Waring Biomedical Research Grant, PI Strong (2013)
Colorado Bioscience Discovery Grant , PI Strong (2013)
National Jewish, Translational Research Initiative, PI Strong (2012)
CSIS Smart Global Health Essay Contest, 1st Place Essay (2010)
Jane Coffin Childs Memorial Fund For Medical Research, Postdoctoral Fellowship (2006 – 2009)
NIH National Research Service Award GM07185. (Cell and Molecular Biology Training Grant) (2003-2005)
Paul D. Boyer Outstanding Teaching Award (2003)
Amgen-MBI Dissertation Year Award (2004)
UCLA Dissertation Year Fellowship (2004)
Role Model Award (2004)
Glen T. Seaborg Poster Award (2004)
Howard Hughes Medical Institute Undergraduate Research Grant (1996)
UCSB College of Letters and Science Award for Outstanding Research (1997)
HHMI Award for Outstanding Undergraduate Research (1997)

TALKS
American Society for Microbiology Biodefense Conference (2003)
10th International Conference on Microbial Genomes (2002)
Lake Arrowhead Biological Chemistry Retreat (2002)
UCLA Bioinformatics Seminar Series (2004)
UCLA Molecular Biology Interdepartmental Retreat (2003,2004)
West Coast Protein Crystallography Conference (2005)
MIT iGEM T3 (2007)
National Jewish Health (2009)
Harvard Medical School, Dept. of Genetics (2009)
University of Colorado, Denver, Computational Bioscience Program Seminar (2010)
Colorado State University, Front Range TB meeting (2010)
Tuberculosis Trials Consortium meeting TBTC (2011)
University of Colorado, Infectious Diseases Department Grand Rounds (2012)
Front Range Mycobacteria Conference (2013)
University of Colorado, Denver, Biology Seminar Series (2013)

POSTER PRESENTATIONS
Mycobacterium tuberculosis Keystone conference (2003,2005)
TB Structural Genomics Consortium Retreat (2001, 2002, 2003)
UCLA Bioinformatics Recruitment Program (2002).
24th Annual MBI Lake Arrowhead Conference (2001)
NIH Protein Structure Initiative Workshop (2004)
12th International Conference on Microbial Genomes (2004)
1st Annual Duke Systems Biology Symposium (2006)
Harvard Medical School Genetics Retreat (2007)
New England TB Retreat at the Broad Institute (2007)
Jane Coffin Childs Annual Symposium (2007, 2008)
Pacific Symposium on Biocomputing (2011 - 2013)

Michael Strong, Ph.D.

COMMITTEES/ORGANIZER
UCLA Faculty Executive Committee (2003-2004 school year) Graduate Student Representative
Molecular Biology Interdepartmental Program (2003-2005) Graduate Student Representative
Biological Sciences Council (2004-2005 school year) MBI Graduate Student Representative
National Jewish Health, Integrated Center for Genes, Environment, and Health, Genetics Group Meeting Co-organizer(2010,2011)
University of Colorado, Denver, Computational Bioscience Program, Admissions Committee (2010-present)
University of Colorado, Denver, Computational Bioscience Program, Preliminary Exam Chair (2011)

MEMBERSHIPS
American Society for Microbiology
University of Colorado, Center for Global Health, Affiliate
International Society for Computational Biology