®

QP-LiverOptimizing liverdisease evaluation

CAUTION-Investigational device. Limited by Federal law to investigational use.

Discover QP-Liver ®
Chronic liver disease is a major healthcare burden,
causing high morbidity and mortality rates and straining
medical resources.
It accounts for 2 million deaths, representing
approximately 4% of global casualties1. Non-alcoholic
fatty liver disease (NAFLD), the most prevalent liver
disorder globally, is characterized by fat accumulationin the liver (steatosis).
Patients with widespread liver disease andmetabolic disorders often have abnormal liver irondeposits. While histopathological examination isconsidered the gold standard, it has limitations suchas invasiveness, sampling errors, variability, and patient
discomfort.
Our innovative approach eliminates the need forinvasive procedures, providing valuable insights for
informed decisions and improved patient care.

With QP-Liver®, personalized liver disease
management is made possible through advanced
technology, including early detection, precise
monitoring, and personalized treatment plans.
QP-Liver® is a post-processing solution that
performs fully automatic analyses of abdominal
MRI examinations containing a multi-echo chemical
shift (MECSE) sequence. Through this innovative
approach, we generate parametric maps of fat andiron, offering voxelwise resolution and a structured
quantitative report that compares liver values withnormative data.
Our cutting-edge tool quantifies fat and ironconcentration, enabling comprehensive steatosis
and iron overload evaluation. By delivering accurate
measurements and comparative analysis, as well as
improving the quality of radiologist reports, healthcare
professionals can improve the decision-makingprocess.

Advanced tech for improved
reporting and workflow•

Integration with clinical workflow and PACS, ensuring
seamless operation and enhanced efficiency.

•Supports clinical workflow and improves decision making
for Liver MRI exams.

•Automates MRI-based whole-liver segmentation, saving
time and reducing manual labor.

•Rapid fat and iron quantification provides precise
measurements to assess disease severity more accurately.

•Correlates quantification with digital pathology data2,
enabling comprehensive analysis.

•Reduces the need for invasive procedures, minimizing
patient discomfort and associated risks.
Figure. (Left) 3D liver, pancreas, and hepatic vein model segmented from a MECSE magnetic
resonance imaging. (Right) Representation of fat concentration in liver tissue.

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CAUTION-Investigational device. Limited by Federal law to investigational use.

QP-Liver ®:Optimizing liver disease evaluation

1. AI-Segmentation3Sex, Age Female, 46 Years
Accesion number 1234®

QP-Liver | v0.1.0

Fat & Iron Quantification

Date: 05/07/2017

Abdominal perimeter: 125.31 cm
Liver volume: 1820.00 mL∗PDFF (%)

p25

11.96

p75

18.88

PDFF median05†10LIC (mg/g)

2. PDFF* and iron concentration3-4

51.7±20.3 1.5±0.5

6.27

MEDIAN−1R2 (s )13.6±10.2

MEAN ± sd

40.52

1.16

50.65

1.48

61.05

1.81

‡

LIC median

1520253035

4005101520200

30

Automate whole abdomen and liver segmentation with ourstate-of-the-art tool, saving valuable time for clinicians by eliminating
the need for manual segmentation.

150

Accurately quantify fat and iron in the liver, with the highestcorrelation to liver biopsy, while controlling all possible confounders3.
*Proton Density Fat Fraction (PDFF)

20100

10500Quantification
The metrics are shown as the mean, standard deviation
thth(sd), 25 and 75 percentiles (25p and 75p respectively) and the median. Metrics are calculated over theentire liver volume. On colored bars, the interquartile
range of the proton density fat fraction (PDFF) and liveriron concentration (LIC) is shown, based on the table
results. Colours are based on literature.

Image processing
Parametric maps are selected from biggest liver volume slice. The complete series and parametric mapsof the entire volume can be viewed in PACS. The distribution of fat and iron is visualized using a heatmap.

†Henninger B, Alustiza J, Garbowski M, Gandon Y. Practical guide toquantification of hepatic iron with MRI. Eur Radiol. 2020;30(1):383-393.
doi:10.1007/s00330-019-06380-9

Gu Q, Cen L, Lai J, et al. A meta-analysis on the diagnostic performance ofmagnetic resonance imaging and transient elastography in nonalcoholic fatty
liver disease. Eur J Clin Invest. 2021;51(2):e13446. doi:10.1111/eci.13446

3. Structured reporting0‡

Empowered by AI, QP-Liver® generates a comprehensive
quantitative report that includes the most suitable parameters
for enhanced patient care in daily clinical practice.

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Contacto: sales@quibim.com
EU: +34 961 243 225 / US: +1 201-290-6110

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REFERENCES:
1. Devarbhavi, H., et al. Global burden of liver disease: (2023 update). Journal of Hepatology.
2. Martí-Aguado D., et al. Automated Whole-Liver MRI Segmentation to Assess Steatosis and Iron
Quantification in Chronic Liver Disease. (2021). Radiology.
3. Jimenez-Pastor A., et al. Precise whole liver automatic segmentation and quantification of PDFF and R2*
on MR images. (2021) Eur Radiol.
4. França M., et al. Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liverdiseases with MRI. (2017) Abdom Radiol (NY).

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