2023年 6月 9日

灘

バ イオ メカ ニ ク ス 懇話会

日本機 械学会 北海 道支部

第 41回 講演会

(共 催 :バ イオメカニ クス懇話会 ,日本機械学会北海道支部)
主査

大橋俊朗

下記 の要領にて第 41回 講演会 を 日本機械学会北海道支部特別講演会 の共催 として開催 いた します。皆様 のご参加 をお待 ちしてお ります。
■コロ巨

日時 :2023年 7月 6日

場

所 :北 海 道 大 学 工 学 部 工 学 部 L tt L252

講演(木 ), 10:30〜 12:00:

10:30… 11:15「Mechanical Factors for Pre― (Dsteoanhritis」

Prof. Ashvin Tharnbyah, IDepa威 lent of lChenlical and iⅥ aterials Engineering,
University of Auckland,New Zealand:γAbstract:The aim of our research has been to understand, from mechanical and structural viewpoints,
the initial degenerative processes in the joint tissues, related to the initiation and progressionof osteoarthritis (OA). To this end we have established an animal model to study early or
pre-OA joint tissue degeneration. Our work is framed around addressing three researchquestions. Does the initiation of OA begin with changes in (1) cartilage or bone, (2)proteoglycans or collagen, (3) cells or tissue? Our studies have shown that in the early
degenerative state of the joint tissues, where macro-scale mechanical properties are yet to beaffected, micro-to-nano scale destructuring of the collagen network had already taken place.
These collagen network changes were found to be strongly associated with bone cement-line
microstructural changes. The changes in the bone-cement line were indicated by the presenceof 'bone spicules', which were remarkably similar to 'cutting cones' seen in primary boneformation during fracture healing. This similarity provided a mechanical rationale for the bonechanges in the joint system in early tissue degeneration. The collagen network and bone
structural changes were also associated with significant changes in an ensemble of proteins.
These included certain SLRPs, angiogenic proteins and TGF-B. High resolution imaging of thechondrons, in tissues exhibiting early cartilage degeneration, further revealed fibrillar-structurechanges in the territorial matrix and pericellular capsule, showing a morphology likened tothickened baskets of fibrillar encapsulation of the chondrocytes. The significance of the above
descriptions, of the multi-length scale tissue and cell mechanics in the joint, are discussed witha view on how OA is initiated by mechanical factors.

11:15 - 12:00
l-Safer Personalised tMedical lmplants.l

Prof. Peter Vee Sin Lee, Department of Biomedical Engineering, University of[Melbourne, Australia
Abstract:
Advances in computer-aided engineering, patient-specific computer models, and additive
manufacturing transform patients' treatment througli personalised solutions. Manufacturers
and hospitals are now trialling 'bespoking' as the new standard of care in orthopaedics andmaxillofacial surgery. However, there are significant challenges to facilitating personalised
medical implant commercialisation and widespread use. Regulatory frameworks for
personalised implants are in their early stages. Current standards for testing off-the-shelfdevices are not directly transferrable to devices designed for individual patlents. Instead,future test standards could be based on information from the patientlr uruto*y and evenlifestyle. There is no well-defined framework or methodology to iupport the use and increase
personaljsed implants' success rate. The fabrication of the implant is only the first step.
Successful treatment requires a comprehensive approach to optimis" ih" use of tie
personalised medical device. This presentation will focus on the dwelopment of a seamless
framework based on the Measure-Model-Manufacture-Manage (aM) for point-of-caremanufacturing. Comprehensive biomechanical measurementJ witt- be used to build
patient-specific biomechanical models to represent the underlying physiology ofthe humanbody. The models will be used to analyse icenarios that are ioo .ip"rsive- or infeasible toperform on patients directly (e.g. loading an implant to failure in the human body).
The aim in
the measure-model stage is to optimise implant/device design that considers all
the biomechanical information before manufacturing using 3D printing. Finally, themeasure-model-manufacture becomes a reinforcing loop that improves patiart management
and outcome. The presentation will also discusi our experi.r,." u.rd benefits, to- u
researcher's perspective, working closely with physicians, industry, and, government leaders inpushing the frontiers of personalised medical impiants.

世話人 ・ 問 い合 わせ 先大橋俊朗:北海 道 大学大 学院 工 学研 究 院人機 械 ・ 宇 宙航 空 工 学部 門

■1&Fax:011¨ 706‑6424,Em江 1:ohashi@cng.hokudai.ac」 p