HP 152aAerosol Propellant

Toxicity Summary for 1,1-Difluoroethane; Hydrofluorocarbon(HFC-152a)

Technical Information
Hydrofluorocarbon 152a has a low order of toxicity on bothof this experimental study, HFC-152a was not

an acute and chronic basis. Although a TLV has not been

carcinogenic and produced no life-shortening toxic effects

established for HFC-152a, a value of 1,000 ppm (v/v;

in rats exposed by inhalation for 24 months at

8-hour TWA) seems appropriate based on its low toxicity

concentrations ≤25,000 ppm (v/v).

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and analogy to other fluorocarbons.

In a study5 designed to determine reproductive toxicity

The main physiological action of HFC-152a is that of “weakpotential, groups of 27 pregnant rats were exposed byanesthesia” at high levels. Its 4-hour Approximate Lethal

inhalation to 5,000 or 20,000 ppm HFC-152a for 6 hours/

Concentration (ALC) in rats is 383,000 ppm . Like otherday on days 6-15 of gestation. There was no evidence of

halocarbons and hydrocarbons under gross misuse ormaternal toxicity, embryo toxicity, or teratogenicity underabuse conditions, HFC-152a is capable of sensitizing thethese experimental conditions. In another study6 (Amesheart to the body’s own adrenaline. However, even inTest) designed to screen for mutagenic potential, HFC-

experimental screening studies using dogs and simulating

152a was not mutagenic in Salmonella typhimurium

stress with a large intravenous dose of adrenaline, cardiac

bacteria, with or without metabolic activation.

1

sensitization was not observed at exposure levels below
150,000 ppm2.

In conclusion, based on acute and chronic animal toxicity
studies and many years of human experience, HFC-152a at

In a sub-chronic inhalation study , rats were exposed toor below an occupational limit (8-hour TWA) of 1,000 ppm

HFC-152a at 100,000 ppm for 16 hours daily for 2

should pose no hazard relative to general toxicity,months with no adverse effects except for microscopic

carcinogenicity, mutagenicity or teratogenicity. Thisevidence of slight respiratory irritation. In a more recent

fluorocarbon exhibits a very low degree of reactivity instudy , when rats were exposed at 100,000 ppm for 6

biological systems.

31hours/day, 5 days/week for 2 weeks, there were no
significant effects relative to clinical, hematological, bloodchemistry, urine analytical, or histopathological indices.
A lifetime inhalation toxicity study4 has also been
conducted on HFC-152a. Rats (120 #/sex/exposure level)
were exposed for 6 hours/day, 5 days/week for 24 months
to 0, 2,000, 10,000 or 25,000 ppm. Under the conditions

HP 152aAerosol Propellant

References1.

Unpublished DuPont Haskell Laboratory Data, 1975.

2.

Reinhardt, C. F., et al. Arch Environ. Hlth. 22: 265-279,1971.

3.

Lester, D., and L. A. Greenberg. Arch. Inc. Hyg. Occup.
Med. 2: 335-344, 1950.

4.

Unpublished DuPont Haskell Laboratory Data, 1982.

5.

Unpublished DuPont Haskell Laboratory Data, 1979.

6.

Longstaff, E., et al. Toxicol. Appl. Pharmacol. 72: 15-31,1984.

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Replaces: H-04239
C-10802 (3/16)