September 2023
Shiseido Company, Limited

Research and Development

Shiseido, in collaboration with RIKEN, develops novel skin prediction
models based on relationships between skin, body, and mind
- Application to development of original algorithms
that can serve as a compass directing to each individual's own beauty Shiseido, through joint research with RIKEN*1, has comprehensively and quantitatively elucidated
physical and psychological conditions that are related to the conditions of the skin, leading to success indeveloping innovative skin prediction models. In addition, the company has created its own beauty
algorithms, which combine the novel skin prediction models and research knowledge the company has
accumulated over the past 100 years or more. In the future, the algorithms will be evolved to contain morethan 2,000 types of skin-body-mind relationships. This is expected to accelerate the development of new
approaches, including the proposal of lifestyle habits focused on the conditions of the body and mind inaddition to the cosmetic product-based care, which will lead to a state of harmony between the skin, body,and mind, in order to help each and every consumer to actualize their "ideal skin" and "best possible state."
Furthermore, these algorithms will continue to evolve with the input of various research results from newstudies in and outside the company, while also reflecting changes in society and the changing lifestyles ofconsumers that come about as a result of social change.
The results of this study were presented in part at the 33rd IFSCC Congress in Barcelona*2 (2023/9/4–7).
*1. Period of joint research: April 1, 2020 through December 31, 2022
*2. IFSCC: The International Federation of Societies of Cosmetic Chemists

Figure 1. Elucidation of the relationships between the skin, body, and mind

Research background
Under the company's vision for 2030, Personal Beauty Wellness Company, which aims to realize thehealth and beauty of each individual throughout his or her life, Shiseido has been working toward therealization of a sustainable world where everyone can enjoy a lifetime of happiness through the power ofbeauty. In order to realize this vision, the company is accelerating the creation of Beauty Wellness
innovations to "achieve healthy beautiful skin from within the body" by elucidating the connections between

the skin, body, and mind, and contributing to the prevention of skin irregularities using approaches that gobeyond the use of cosmetic products, in addition to improving the current skin conditions and predicting
future skin conditions.
In research and development, we are promoting studies that incorporate the technologies to "visualize
the conditions of the mind," which we have long been pursuing in the area of kansei*3 research, our strong
point, and strengthening analyses that incorporate data science methods in collaboration with outsideparties. With regard to the latter, we have established a joint research program with Hirosaki University forthe purpose of promoting scientific research on the skin, body, and mind relationships and implementing
it in the society*4. Other efforts include the development of quick and highly accurate ways to analyze large
amounts of data obtained through research, and to this end, we have concluded a comprehensive
partnership agreement on data analysis with DeNA Life Science, Inc.*5. As one of the outcomes of efforts
related to the aforementioned studies, we have elucidated the relationships between the skin, body, andmind, and created our own beauty algorithms encompassing this new knowledge.
*3. Kansei research is an approach to product innovation that focuses on emotional engineering. Fusing aesthetics, sensory psychology
and design, it seeks to create objects and experiences that appeal to the senses (visual, olfactory, auditory and tactile) in order to arousean emotional response in the user.
*4. Shiseido and Hirosaki University Graduate School of Medicine Jointly Establish Research Program “Department of Beauty WellnessScience” (2022) https://corp.shiseido.com/jp/news/detail.html?n=00000000003464*5. Shiseido and DeNA Life Science Sign Comprehensive Partnership Agreement on Data Analysis (2022)
https://corp.shiseido.com/jp/news/detail.html?n=00000000003529

Shiseido succeeds in elucidating the relationships between the skin, body, and mind and visualizing themas mathematical formulaeThis time, with the aim to clarify the relationships between the skin, body, and mind, we conducted joint
research*1 with a team led by Dr. Kei Mizuno, Senior Researcher at the RIKEN Center for Biosystems
Dynamics Research, who has a proven track record in research to develop, for example, Health Compassthat allows for visualization of an individual's health levels using various indices.*5 We carried out a study
targeting healthy Japanese women in their 20s–40s, in which measurements of skin conditions such as
age spots and dullness, wrinkles, and moisture, as well as physical shape and composition, bloodcomponents, lifestyle habits, and psychological indicators were performed. In order to reveal what factorsof the body and mind are associated with the conditions of the skin, we set out to create mathematicalformulae (novel skin prediction models) that could explain the measured skin indices in terms of physicaland psychological indices. As a result, we succeeded in obtaining multiple mathematical formulae. For
instance, with respect to the amount of moisture in the stratum corneum of the skin, the formula shown
below was obtained; this formula clearly shows that high / low amounts of moisture in the stratum corneum
are related to the body's oxidative stress state, physical constitution, electrolytes (minerals) in blood, grip
strength, and so on (Formula 1, Figure 2). To date, a very few attempts have been made to reveal thephysical and psychological conditions that are related to skin conditions in a comprehensive andquantitative manner. In this sense, the novelty of the findings obtained in the present study is consideredextremely high.

Amount of moisture in the stratum corneum = a × Oxidative stress level+ b × Physical constitution + c × Blood electrolytes + d × Grip strength + …
Formula 1. Obtained mathematical formula representing the relationships between the amount of moisture in the stratum corneum
and each physical / psychological factorsFigure 2. Relationship between the developed novel skin prediction modelfor the amount of moisture in the stratum corneum and actual values
The points are properly gathered along the straight line, indicating that the accuracy of the novel skin prediction model is high.

Development and future application of Shiseido's own beauty algorithms
Taking this opportunity with the findings obtained in collaboration with RIKEN regarding the relationships
between the skin, body, and mind, Shiseido has created its own beauty algorithms that include therelationships between the skin, body, and mind by integrating the company's knowledge accumulated fromthe past 100 years or more. In order to realize the company's vision, Personal Beauty Wellness Company,
Shiseido will strive to further accelerate the creation of various Beauty Wellness Innovations not limited tocosmetic products to "achieve healthy beautiful skin from within the body," and the algorithms created in
the present study will serve as a basis to this end. The algorithms, which include the results of the presentstudy, will enable us to quantitatively understand the relationships between the skin, body, and mind, which
in turn will allow us to develop and propose, with higher accuracy than ever, measurement technologies
that consumers can deepen their understanding about their own skin, and care that will help each andevery consumer to actualize their "ideal skin" and "best possible state. Our algorithms will continue to
evolve to contain more than 2,000 types of skin-body-mind relationships in the future, being fused with thelatest knowledge that will be revealed by future studies in and outside the company, while also reflectingchanges in society and the changing lifestyles of consumers that come about as a result of social change.
About Our R&D Strategy:
This study was conducted with the aim of elucidating the relationships between the skin, body, andmind under Future Beauty INNOVATION, one of the three pillars of Shiseido's R&D strategy.
-Integrated Report 2022 (Beauty Innovation)

https://corp.shiseido.com/report/en/2022/value_creation/innovation/-Keywords

Future Beauty INNOVATION; elucidation of the relationships between the skin, body, and mind<Reference>
Researchers' challenges■R&D Philosophy DYNAMIC HARMONY approachThis research was carried out under the Individual/Universal approachof Shiseido's R&D philosophy, DYNAMIC HARMONY. Focusing on theuniversality that is commonly held among individuals and the individuality
as expressed in varying forms such as age, gender, race, and lifestyle ineach person, Shiseido has ventured into research on the elucidation ofskin-body-mind relationships.
■Visualize the connection between the skin, body, and mind using cuttingedge data science"When I am emotionally depressed, my skin condition also
deteriorates, and everything goes wrong..."; We think not a few people

Chieko岡村智恵子グループマネージャー
Okamura, Group Manager

have had similar experiences to this. The skin, body, and mind areconnected in a variety of ways, and we have been researching this topic suspecting that we may be able
to think more broadly about solutions to beauty issues than we do now.
In the present study, together with Dr. Mizuno and his colleagues, we made full use of data science tocapture people as a whole, not just as parts, and also, to understand the relationships between the skin,
body, and mind in a pre-disease state (condition in which one suffers no illness but has some disordersthat are making their body less healthy temporary or chronically), rather than in the state of extreme
disease. This is what makes our study novel and interesting. The marriage between the Eastern
philosophical concept of the comprehensive link between the skin, body, and mind and science, i.e., data
science, is reminiscent of Shiseido's founding, which originated from the fusion of Western science andEastern wisdom.
The results of the present study have led us to visualize connections that had not been considered
relevant until now, such as that between grip strength and skin. Going forward, we will continue to carryout various studies aiming at the prediction and the prevention of skin disorders and proposal of new
solution to beauty issues.
Shiseido's R&D Philosophy DYNAMIC HARMONY-Shiseido Formulates Its Unique R&D Philosophy "DYNAMIC HARMONY" (2021)

https://corp.shiseido.com/en/news/detail.html?n=00000000003252-DYNAMIC HARMONY website:

https://corp.shiseido.com/en/rd/dynamicharmony