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I and pharmacokinetic study ofcisplatin-mitomycin-vincristine in thetreatment of advanced squamous cell
carcinomas of the head and neck.
Forty patients with squamous cell
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were treated with the combination of
cisplatin (100 mg/m2 on day 1),
mitomycin (10 mg/m2 on day 1), andvincristine (1 mg/m2 on day 1, withrepeated cycles given every 21 days).
The starting dose of cisplatin wasdetermined by an escalation dose
finding study. The dose-limiting
toxicity of the combination wasmoderate ototoxicity. The
recommended dose of cisplatin, interms of area under the concentrationtime curve, in order to be given withthis combination is 110 mg/m2 on
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