Vol. 21, No. 1 (2022)

21

1COVID-19
Yuqi ZHOU
Jeffrey HARMON

Ting-Hui XIAO············· 1Walker PETERSON
Mohammad SHIFAT-E-RABII Yan ZHUANG Xuwang YIN
Abu Hasnat Mohammad RUBAIYAT Yunjie DENG, Hongqian ZHANG
Gustavo K. ROHDE

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Koh Isabel SY··········· 16

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··········· 20

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COVID-191231, Yuqi ZHOU1,, Ting-Hui XIAO1,,,
1
11,451Jeffrey HARMON ,,,,, Walker
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PETERSON ,, Mohammad SHIFAT-E-RABII , Yan ZHUANG , Xuwang
7
YIN , Abu Hasnat Mohammad RUBAIYAT7, Yunjie DENG1, Hongqian ZHANG1,8, Gustavo K. ROHDE6,7,3,9,10,2,*1,11,12,2

1,3,4,5CYBO, 6,8, 10,7,9, 11, 12Analyzing circulating platelet aggregates in patients with COVID-19by massive image-based single-cell profiling
Hiroshi KANNO1, Yuqi ZHOU1, Masako NISHIKAWA2, Ting-Hui XIAO1, Takuma
SUZUKI3, Yuma IBAYASHI1, Jeffrey HARMON1, Shigekazu TAKIZAWA1, Kotaro
HIRAMATSU1,4, Nao NITTA5, Risako KAMEYAMA1, Walker PETERSON1, Jun
TAKIGUCHI2, Mohammad SHIFAT-E-RABBI6, Yan ZHUANG7, Xuwang YIN7, Abu
Hasnat Mohammad RUBAIYAT7, Yunjie DENG1, Hongqian ZHANG1, Shigeki
MIYATA8, Gustavo K. ROHDE6,7, Wataru IWASAKI3,9,10, Yutaka YATOMI2, Keisuke
GODA*1,11,12
1

Department of Chemistry, University of Tokyo
Department of Clinical Laboratory Medicine, University of Tokyo Hospital3
Department of Computational Biology and Medical Sciences, University of Tokyo
4
Research Center for Spectrochemistry, University of Tokyo
5
CYBO, Inc.
6
Department of Biomedical Engineering, University of Virginia
7
Department of Electrical and Computer Engineering, University of Virginia
8
Research and Development Department, Central Blood Institute, Japanese Red Cross Society
9
Department of Biological Sciences, University of Tokyo
10
Department of Integrated Biosciences, University of Tokyo
11
Institute of Technological Sciences, Wuhan University
12
Department of Bioengineering, University of California, Los Angeles
2Abstract
Microvascular thrombosis is frequently observed in COVID-19 patients. COVID-19 autopsy reports haveconsistently found widespread diffuse microthrombi within peripheral capillaries and arterioles in the lungs, theheart, and other organs. However, due to the lack of instruments to statistically investigate platelet aggregation indetail, the transient mechanism of COVID-19-associated microvascular thrombosis remains unexplained. In this*113-0033

7-3-1

E-mail: goda@chem.s.u-tokyo.ac.jp

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