MCI GEL
XtalSpeed

TM

DIAIO

TM

spherical and sharp particle size distribution

offeres packing materials and packed columns,
under strict quality control

Wide range of product line
MCI GEL™ has been designed based on technology of
the world famous Diaion™ and Sepabeads™,
specialized in polymeric packing materials includingfrom analytical to preparative use,
for ion exchange, reversed-phase mode

Abundant accumulation of technology
and experience
for more than 50 years, MCI GEL™ has been used for
HPLC applicationsd TM

Purificationof sugar

70 th

Mitsubishi Chemical is building on
more than 70 years of experiencein ion exchange manufacturing.
We continue to aim to achieve atruly KAITEKI society signifying asustainable condition that delivers
comfort for people, society and
Earth.

Water treatment
for boiler

Ion
Exchange
Resin

Ultra pure waterfor electric devices

C

hr

Water treatment
for power plantsom

Purification of foods
and food additives

S p e e dTM

Purificationof medicine

SEPA
B
E
A
D
S
TM

Persistence and highest quality

MabSpee

Excellent performance

Reaction
catalysts

N TM

CONTENTS
1 Column selection guide

3〜4
3
4

Coumn selection guide
Product list by particle size and separation mode

4

USP List

2 Ion exchange columns and materials

5〜22

Features
Column list and materials［Applications］Sugars・Sugar alcohols・Organic acids《CK08,06 series》
Examples of peak retention time《CK08E series》
Oligosaccharides《CK04S・CK04SS・CK02A・CK02AS》
Amino acids《CK10U》
Sugars・Organic acids《CA08F》
Nucleic acids etc.・Sugars・Human urine《CDR10》

3 Ion chromatography columns and materials
Column list and materials
Cations《CHK45》
Anions《SCA04》

Ion exchange chromatography column《XtalSpeed
Column list and materials［Applications］Rituxan《XtalSpeedTM series》

TM

series》

Aqueous size exclusion columns《CQP series》
Size exclusion chromatography columns
Column list and materials［Applications］Calibration curves《CQP series》
Proteins・Water soluble polymers《CQP series》
1

Polymeric chromatography materials《CHP material series》
Chromatography material list
[Applications] Organic compounds《CHP material series》

49〜56
49
50〜53

23〜27

7 SPE sorbent series

28〜32

Bioseparation columns

33
33
34
35
36〜48

6 Chiral separation columns

26〜27

4 Bioseparation columns and materials

Polymeric partition chromatography columns and materials MCI GELTM CHP series
Separation mechanism of CHP series
Column list
Column durability[Applications] Organic compounds・Insulin・Peptide《CHP column series》

5
6
7〜12
13
14〜16
17〜18
19〜20
21〜22

23〜24
24〜25
25

［Applications］Cations《SCK01》

5 Analytical and preparative chromatography columns and materials for pharmaceutical applications 33〜53

28

29〜30
29
30
31〜32

Separation mechanism of CRS series[Applications] Optical isomers《CRS10W・CRS15W》
Separation conditions for various amino acids

Solid phase extraction sorbents
Synthetic adsorbents and reversed-phase material list
Chelating type list

54〜59
54
55〜58
59

60
60
60
60

8 MCI GEL™ column list

61〜62

9 MCI GEL™ material list

63〜66

10 Compounds index

67〜75

31
31
32
32

2

Column selection
guide

カラム選択の手引き

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

固相吸着剤

Chiral separation
columns

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

21

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

CDR10

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

A rigid, spherical polydivinylbenzene particle, 5 to 10 µ in diameter

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

Chiral separation
columns及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

L73

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

34

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

SPE sorbent series

Ion chromatography
columns and materials

SPE sorbent series
Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Ion chromatography
columns and materials

CMG20/C04

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

A rigid, spherical polymetacrylate, 4 to 6 µm in diameter

11

6

10

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

L71
Compounds index

Compounds index

Compounds index

Full range

CHK40
CHK45

Compounds index

Compounds index

Compounds index

43Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene
copolymer in the sodium form, about 6 to 30 µm diameter

10

L58

Organic Compounds

9

9
9

10

34

L39

9
9
9
A hydrophilic polyhydroxymethacrylate gel of totally porous spherical resin
9

9
9

9
9

Mix mode

33〜53
2 〜12

10

A methacrylate-based size-exclusion packing for water-soluble samples

Organic Compounds

CMG20
CHPOD

10

L38

9

33〜53

Normal
Phase

10

31

8

ReversedPhase

5 〜7

Organic Compounds

Full range

L32 8

8
(α-amino acids・
α-hydroxy carboxylic acids) 8

8

Optical isomers

8

10

L37

Packing having the capacity to separate proteins by molecular size over a range of 2,000
CQP30
to 40,000 Da. It is a polymethacrylate gel

Mix mode

CHP20
CMG20
CHP07

Organic
Solvent
Soluble10

54

6

ReversedPhase

6

31

10

A chiral ligand-exchange
resin packing-L-proline
copper complex covalently
8
8
8 bonded to CRS10W
CRS15Wirregularly shaped silica particles, 5 to 10 µm in diameter

3 〜7
1.5〜12

Sample

8

6

SCA04
SCK01
CHK456Ion
Chromatography

L31
1 〜7

1 〜13

M.W.
<2,0007〜13
54〜59
CK08E Series
CRS10W
CRS15W

CDR10

5

CQP10
CQP30
CMG20/C04
CMG20/C10
10
CK08S
CK08E
CK04S
CK02A

10

23

7,11〜12

1 〜14
1 〜13

34,45,48

A hydroxide-selective, strong anion-exchange resin-quaternary amine bonded on latex
particles attached to a core of 8.5-µm macroporous particles having a pore size of 2000 Ǻ SCA04
units and consisting of ethylvinylbenzene cross-linked with 55% divinylbenzene

Organic adids
1 〜7

CK10U
CA08F 5
CDR10
Ion
Exclusion

7

CK08EH

2 〜12

4

9

31

34,45〜48

CQP06

4
Water
Soluble7

Amino acids, Nucletide

Full range

CK04S
CK04SS

6 〜7

4

4

7
CHK40
CHK4576 〜7Size
Exclusion

8

L257

Packing having the capacity to separate compounds with a molecular weight range from
100-5000 (as determined by polyethylene oxide), applied to neutral, anionic, and cationic
CQP06
water-soluble polymers.
A polymethacrylate
7
7 resin base, cross-linked with polyhydroxylated
7
ether (surface contained some residual carboxyl functional groups) was found suitable

CK02A
CK02AS

Phase

3

Saccharrides

34

2 〜12

CMG20
3
CHPOD
CHP20
CHP07

3
Reversed-3

7

A rigid, spherical styrene-divinylbenzene copolymer, 3 to 30 µm in diameter

33〜53

CMG20
CHPOD
CHP20
CHP07

L17

23〜27
23〜25

CHP20/C04
CHP20/C10
7

7

6
L21

33〜53
Full range

7
Strong cation-exchange resin consisting of sulfonated cross-linked styrene-divinylbenzene
6
CK08EH
copolymer in the hydrogen form, 6 to 12 µm in diameter

6

ColumnPage
MCI GELTM

21〜22
Nucleotides

5

PACKINGUSP Code5●USP LISTING OF MCI GELTM

17〜 1819〜22
Amino acids
5 Organic acids
Saccharrides

5

31〜32

5

5

CRS

Ligand exchange

PeptidesCHPOD/C04

14〜16

6
6 sulfonated cross-linked styrene-divinylbenzene
6Strong cation-exchange
resin consisting of
CK08EC
copolymer in the calcium form, 5 – 15 µm in diameter

8

33〜53

2 〜12

5

Ion
Exclusion
LigandExchange

Proteins,Peptides

XtalSpeedTM

Ion
Exchange

M.W.
>2,0007

Full range

2 〜12

5

7

33〜53

6

5

5

4

3 Proteins,Peptides 3

4

4

2 〜12

Mix mode

CHPOD/P30

CMG20/C04

Normal phase

29〜31

4
14〜16

4
Oligosaccarides

CMG20/P30
CMG20/P10

3
CHP07/C10

Oligosaccarides

6

CHP87/P120
CHK404
CHK45

AnionsCations

6

CMG20/P150
CMG20/C10

3
CHP07/C04

Proteins,Antibody

CQP10
CQP30

4

Organic Compounds
peptideOrganic Compounds
peptide4

5

CHP85/P120

4

CHP07/P120

3

3
3

CSP50/P10 CHP50/P20 CHP50/P30

3

CHP20/P120
CHP20/P50

CHP20/C10 CHP20/P20 CHP20/P30

CHP20/C04

CQP

Size exclusion

31〜32

3

Ion chromatography

Proteins,Biopolymers
Water soluble polymers

L19

7

Nature of sample

CHP20/P70

2

2
2
SCK 2

Size
Exclusion

Ion exchange

CHK452
SCA

2

CA

CA

CA

CA
CDR10
XtalSpeedTM

Pages
Applications

pH range

2
2
2
2

2
2

CK

1
CK

1
CK
CK

1

1
1
1
1

1

CQA_P
CQK_P

2

1

150

1

MCI GEL™
columnAnalytical

1
1
CK

Preparative

50

30
10
5

Particle size
μm
Separation ［ ］
mode

1 Column selection guide1

Separation
mode●Product list by particle size and separation mode

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL Anion
exchange columns

SPE sorbent series

Chiral separation
columns

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

9Compounds index

MCI GEL充 填 剤一覧

MCI GEL™ material list

2. As for analysis of amino acids by MCI GEL™

MCI GEL™ column list

8

MCI GEL
カラム一覧

MCI GEL™ column list

MCI GEL™ CK08EC

1. Please consider using a guard column

8●Note ; Pre-column and guard column

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Cation exchange columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns7

MCI GEL

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications™

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

7™

Ion exchange columns
and materials

Ion chromatography
columns and materials

7

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guide

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

7

7
7

Column selection
guide

Ion chromatography
columns and materials

7

固相吸着剤

AcO-

Compounds index

Compounds index

10

10

MCI GEL™ material list

分離例化合物リスト

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index
MCI GEL™ material list

MCI GEL™ material list

11

Ion exchange columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

及び充填剤

4.6×250Highporous7

Column selection
guide

医 薬 精 密 精 製 用 充 填 カ ラム

生体高分子分離用
充填カラム及び充填剤

77Counter ion

イオンクロマトグラフィー用
充填カラム及び充填剤

SO24MCI GEL™ CDR108イオン交換クロマトグラフィー用
充填カラム及び充填剤

SPE sorbent series

8

カラム選択の手引き

SPE sorbent series

4.6×250

MCI GEL™ CA08F

8

MCI GEL™ column list

20 6

Column selection
guideColumn selection
guideChiral separation
columnsAg+

Ion exchange resins are generally used for analysis of amino acids, sugars, organic acids and amines, etc. MCI GEL™
custom pre-packed columns are specifically designed for each application using the most appropriate packing material
among our product line and using the most suitable column dimensions.
Typical application for each column is shown in this catalog. These data will suggest an appropriate column.

10

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

2

6

10

Bioseparation columns
and materials

620×250
6
6

for HPLC use

Ion chromatography
columns and materials

6 MCI GEL™ CK02AS
6

8

Ion exchange columns
and materials

20

6

Column selection
guide

Na+

Chiral separation
columns2
MCI GEL™ CK02A

Bioseparation columns
and materials

20×250

MCI GEL™ CK04SS

Ion chromatography
columns and materials

11

6

Column selection
guide

4

3. Accumulation of abundant knowledge and experience of applications

Column selection
guide

10×200Ag+

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

6
5

11

5

9

10
10

Na+

5

9

10

H3C CH3

10
10

4

5

Particle size（mode）

10

10

H 3C

10×200

MCI GEL™ CK04S

A＝20μm, S＝11μm
E＝9μm, F＝7μm,
U＝5μm

CH2

11

5

DVB%

SO3 M

Ca+
MCI GEL™ CK06SCCK10U, MCI GEL™ AFR2-PC9is recommended 10
as a pre-column. The AFR2-PC column isvery effective to stabilize base line because it
can trap ammonium ion in eluent. A peakcaused of the ammonium ion may disturb baseline stability.

H3C CH3

6

5

9

8×500

2. Persistence of high quality, excellent separation performance

99
9 H 3C999

gel type, porous type, DVB%, particle size, particle size distribution
analytical use, preparative use

no letter＝Na+, C＝Ca2+
S＝Ag+, H＝H+

9

H+

4

Cation＝K
9Anion＝ACH

CH2

8
7.8×300

4

5

CH

48.0×300
4 MCI GEL™ CK08EH
4

5

CH2
CH
CH2

CH

9
MCI GEL™ CK08ES

9concerning
purity of injection sample. Guard
columns, are listed in the end of this catalog,
should be selected in accordance with a maincolumn.
SO3 M

Ag+

5

CH

8

1. Variety of products

CH2

8×300

MCI GEL™ CK08EC

4

CH

9

Features4●Description of a gel type ion exchange column
CH

Ca2+

7

CH2

8

6

CH

8.0×300
7.8×300

Mitsubishi Chemical Ion Exchange Resins89○Anionexchange2
2 resins
MCI GEL™ CA series

8

Na+

1

○Cation exchange resins
MCI GEL™ CK series

8

8

MCI GEL™ specializes in polymer based packing materials. Specifically, polystyrene polymer based ion exchange
resins are derived from over 50 years of manufacturing experience of Diaion™ product line. MCI GEL™ ion exchange
33
3
3 have been developed
3 and quality. For several
resins for HPLC
with the same attention
to performance
decades,
Mitsubishi Chemical has been providing MCI GEL™ ion exchange columns are offered in a variety of chemistries,
particle sizes and counter ions to support a broad range of applications.

4〈Strongly basic anion exchange resin〉

8.0×300
7.8×300

3

3

MCI GEL™ CK08E

3

1

2

8

11

2

1

2

8

Na+

5

8

7

8

2

1

●Packing materials
Packing materials are available. Please look at P.64 and P.65.

7
7

8×500

4

〈Strongly acidic cation exchange resin〉

8

L19

10

2
5

2

3

●Chemical structure of ion exchange resin

5

7

6

5

5
L58

6

6

4
L17

4

L58

5

4

4

3

3

3

L58
6×120

Na+

2

MCI GEL™ CK08S

Packing material

L58

2Counterion
MCI GEL™ CK10U

Description

3

2

Mono
Oligo- Carboxylic Amine Physiological
Amino
fluid
acid
acid saccharide saccharide

2

1
1

USP
Particle
size
[μm]

Cross
linkage[%]

Columndimensions
I.D×L
[mm]

Product name2

1
Typical usage

1

1
1

1

●MCI GEL™ columns for HPLC
1

1

2 Ion exchange columns and materials

Compounds index

Compounds index

分離例化合物リスト

20
100Compounds index

0

10

20

Compounds index

Compounds index

28
24

MCI GEL™ material list

MCI GEL™ material list

20
16
12
8
4
0

30

20
10
0

MCI GEL充 填 剤一覧

Sorbitol

Fructose
LactoseLactulose

Galactose

Erythritol

MannitolGlucoseFructose

GlycerolEthyl alcohol
Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

30

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

Xylitol

SPE sorbent series

GlucoseDp 2
SPE sorbent series

MCI GEL™ column list

SalicinSPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

RiboseGlucoseChiral separation
columns

固相吸着剤

Fructose

Sucrose

20
10

Dp 3
0

20

10
0
20

10
0

Fructose
SucroseChiral separation
columns

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

20

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

Stachyose
Gentiobiose
LactoseGlucoseMannoseFructose
Adonitol meso-Erythritol
Mannitol

Dp 2

Ion chromatography
columns and materials

GlucoseIon chromatography
columns and materials

GlucoseIon chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns10

GlucoseFructose

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

SucroseIon exchange columns
and materials

Fructose

Ion exchange columns
and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

100

Column selection
guideColumn selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guide

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10
11
10
10
10
10

min.
min.

10

10

10

min.
min.

min.

9
9
9
9
9

8

8

9

9
10

9
9

9

7
7

8

7
7

7

7
7

8

8

8
8
8
8

9
9
9

5

5

5

Column selection
guideColumn selection
guide

Ca2+

8
7

MCI GEL™ CK06SC

7

7

Fig. 2-7 Jam

Fig. 2-2 Apple juice

Fig. 2-1 Sugars

Use for analysis of mono-saccharides and disaccharides.
H+

8
8
8

10
10

MCI GEL™ CK08ES
4

Ag+

Fig. 2-3 Lactulose syrup

6

Ca2+

7

6
6

MCI GEL™ CK08EC

7

6
6

Na+

6

6
6

5

Conditions
ColumnMCI GEL™ CK08SMCI GEL™ CK08E：MCI GEL™ CK08EC
8mm I.D.×300mm
Eluent：H2O：0.6
Flow rate
Column temp.：75℃
Detection：RI

Conditions
Column

5

5

5

5

6
：MCI GEL™ CK08EC
8mm I.D.×300mm
Eluent：H2O
Flow rate
6 ：0.6
6
Column temp.：75℃
Detection
：RI

6

L17
Organic acids with H 3 PO 4 eluent; sugars with distilled water eluent

55Application data of CK08EC
5
5

7

7

min.

5
min.
min.

4

6

4
4
MCI GEL™ CK08EH

3

Fig. 2-8 Sugars/Alcohols

4
4
4

3

CK08EH 8×300, 7.8×300

4

3
3
3

USP

3

Application areas

3

Counter ion

3

3●Column list

4effect44 Gel permeation chromatographic

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

2

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

2

CK08EC 8×300, 7.8×300

3
MCI GEL™ column

4

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

2

Ion chromatography
columns and materials

Column selection
guide1
Ion exchange columns
and materials

Column selection
guide1
Ion exchange columns
and materials

Column selection
guide

1

2

L19
The most general sugar separation column
Highly recommended for fructose and glucose
This column conforms to US Pharmacopeia.

2

1

2

L58
General sugar separation columns

2

1

4

3

3

2
2

1
1

applications; sugars, carboxylic acids, (poly)alcohols, etc.

Cation exchange columns

CK08,06 series

3

2
2

2
2

1
Fig. 2-6 Honey1

1
Fig. 2-5 Sports1drink B

1Fig. 2-4 Sports drink
1 A

Application data of CK08EC

2

SPE sorbent series
MCI GEL™ column list

MCI GEL™ column list

MaltoseGlucoseSPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ material list

MCI GEL
カラム一覧

Maltotoriose

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL充 填 剤一覧

Compounds index

GlucoseAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

MCI GEL™ column list

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

Maltose

Bioseparation columns
and materials

D-Mannitol
D-(+)-Glucose

D-(-)-Fructose

meso-Erythritol
GlycerolEthanol

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Maltotoriose

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

RI (mV)Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

RI (mV)Ion chromatography
columns and materials

Ethanol

D-(+)-Glucose

D-(-)-Fructose

meso-Erythritol

Glycerol

D-Mannitol

Ion chromatography
columns and materials

Ion chromatography
columns and materials

RI (mV)

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

RI (mV)

Column selection
guide

カラム選択の手引き

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

10
10

Compounds index

Compounds index

10Compounds index

Compounds index

Compounds index

Compounds index

10
9

10
10
10
10
10
10
10

8

8

9

9

20 min16
12
8
4
0
20 min16

Conditions
9
Column ：MCI GEL™ CK08E 7.8mm I.D.×300mm
10Eluent ：Milli Q water
Flow rate：0.4
Temp ：50℃
Sample ： Maltotoriose
MaltoseGlucoseInjection ：5μl.
Detection：R I
11

9

9
9
9

6

12
8
4
0
Rs
1.78
1.28
1.73
1.63
1.51
1.86
1.50
1.79
1.23
5.72
0.86
As
1.07
1.01
1.14
1.06
1.03
1.00
0.92
1.01
0.88
1.07
0.94
3.00
Rt
TPN
Stachyose hydrate
4243
7.21
4397
8.02
β-Gentiobiose2249
α-Lactose monohydrate 8.76
1441
10.23
D-(+)-Glucose
9
9
2830
11.78
D-(+)-Mannose
2188
13.27
D-(-)-Fructose
14.76 13744
Ribitol (Adonitol)
15.51 16005
meso-Erythritol
3594
16.86
D-(-)-Salicin
17.88 12043
D-Mannitol
21.90 13235
Xylitol
2381
22.87
D-(-)-Ribose
39Bar (Including system pressure)

Results:
1
2
3
4
5
6
7
8
9
10
11
12
Pressure:
Rs
1.86
1.22
1.77
1.76 9
1.47
1.85
1.43
3.90
1.08
3.09
0.86

6

8

8

8

8
8

6

9
30 min
25
20
15
10
5
0
30 min
25

As
1.04
0.97
1.19
1.09
1.01
1.01
0.84
0.99
0.87
1.35
0.88
2.09
Rt
TPN
Stachyose hydrate
5111
8.25
5504
9.13
β-Gentiobiose3024
α-Lactose monohydrate 9.83
2002
11.27
D-(+)-Glucose
9
3350
12.90
D-(+)-Mannose
2713
14.32
D-(-)-Fructose
15.78 15410
Ribitol (Adonitol)
16.50 17734
meso-Erythritol
18.73 13044
D-Mannitol
4104
19.69
D-(-)-Salicin
22.66 13965
Xylitol
2278
23.75
D-(-)-Ribose
28Bar (Including system pressure)

Results:
1
2
3
4
95
6
7
8
9
10
11
12
Pressure:

6

20
15
10
5

9
6

8
12

8
8
12

8
8

0

11
8

4 5

7
7

3

7

7

10

7
7
7

11
8
5
4

7
7

7

7
7
10
7

3

① Maltose syrup powder

79

12
2
1

Fig. 2-12 Maltose syrup powder

5

5

6
Fig. 2-10 Sugars（Comparison with competitor’s column）

7

6② Competitor’s Column

66② Mixture

6① MCI GELTM CK08EC (7.8×300mm)

Conditions
Column ：MCI GEL™ CK08EC 7.8mm I.D.×300mm
Eluent ：Milli Q water
Flow rate ：0.6
Temp
：85℃
5
Detection：R I

4
20 min
16 4
12
8
4
0

3
Galactose

4

3
3

6

Application data of CK08E

Conditions
Column：7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )Eluent：Milli Q water
Flow rate：0.6
Temperature 6
：75 ℃
6
6
Sample Conc ：40mmol/ml each
Injection：20μL
Detection ：R I

6

2

5

5

5

5

5

5
5
5
5
5

2

20 min
5
0

4

2

16

4 12
8
4

4 0
Rt
TPN
As
1509 1.12
D-(+)-Glucose 10.25
2210 0.98
D-(-)-Fructose 13.37
meso-Erythritol 15.63 15833 0.90
16.32 21608 0.95
Glycerol
16.73 35525 1.69
Ethanol
17.99 10387 0.96
D-Mannitol
Pressure: 38Bar (Including system pressure)

Rs
2.93
2.78
1.50
1.14
2.43

4
4 30 min
25
20
15

4 10
Results:

4

Rs
2.89
2.66
1.40
2.12
1.33

Rt
TPN
As
2085 1.07
D-(+)-Glucose 11.39
2597 0.97
D-(-)-Fructose 14.39
meso-Erythritol 16.59 16899 0.84
17.31 19051 0.95
Glycerol18.18 37357 0.80
Ethanol
18.83 12885 1.00
D-Mannitol
Pressure: 28Bar (Including system pressure)
Results:② Competitor’sColumn 22

Galactose

3

4

1

3
3
3

4

1

4
30 min
25
20
15
10
5
0

1

2

3

2

Fructose

1
Conditions 1
1
1
Column：7.8x 300 mmI.D. (MCI GEL™ CK08EC / Competitor’s Column )Eluent：Milli Q water
Flow rate：0.6
Temperature ：75 ℃
Sample Conc ：40mmol/ml each
Injection：20μL
Detection ：R I

① MCI GELTM CK08EC
2 (7.8×300mm)

3
3
3
3
3

Sucrose2

2

2② Galactose / Sucrose = 0.1 / 99.9

① Galactose / Fructose = 0.1 / 99.9

1

Fig. 2-9 Sugars／Alcoles（Comparison with competitor’s column）

1

2
2

1

Fig. 2-11 Analysis of galactose impurity

1

1

1

Application data of CK08EC

Application data of CK08EC

MCI GEL™ column list

n-BuOH
sec-BuOH
n-PrOHglycerolEthylene Glycol

EtOH
i-PrOHMeOH
n-BuOH

LactoseLactulose

Galactose

SPE sorbent series

MCI GEL™ column list

sec-BuOH

Chiral separation
columns

SPE sorbent seriesn-PrOH

Chiral separation
columns

MCI GEL
カラム一覧

i-PrOH

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

20

10

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

固相吸着剤

EtOH

Dichloroacetic acidAcetic acid

Bioseparation columns
and materials

20
10
20

16

12
8
4

20
10
0
24
20
16

12
8
4
0

Chloroacetic acidIon chromatography
columns and materials

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

Ethylene Glycol

Ion exchange columns
and materials

Glycolic acidIon chromatography
columns and materials

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

MeOH

Ethylene glycol

Diethylene glycol
Triethylene glycol
Acetic acid
Chloroacetic acid

Dichloroacetic acid
Trichloroacetic acid

N-Acetylglucosamine
N-Acetylgalactosamine
Glucose

Oxalic acid

Tartaric acid
Malic acidMalonic acid
Glycolic acid
Lactic acid
Formic acidAcetic acid
Citric acid

Column selection
guide

Ion exchange columns
and materials

生体高分子分離用
充填カラム及び充填剤

MCI GEL™ material list

glycerol

Column selection
guide

イオンクロマトグラフィー用
充填カラム及び充填剤

MCI GEL™ column list

Chiral separation
columns

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

10

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ material list

Compounds index10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Bioseparation columns
and materials

Chiral separation
columns

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

10

カラム選択の手引き

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Compounds index

10

Ion exchange columns
and materials

Bioseparation columns
and materials

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

10
10Compounds index

MCI GEL™ material list

Compounds index
MCI GEL™ material list

Compounds index

MCI GEL™ material list

11

10

12

8

10

9

8

8

8

8

8

Column selection
guide

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns7

Ion exchange columns
and materials

Ion exchange columns
and materials

Chiral separation
columns

SPE sorbent series
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

7

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

SPE sorbent series

7

Bioseparation columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

SPE sorbent series

7

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

7

7

Column selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

7

4

10

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

6

9

10

：MCI GEL™ CK06SC
8mm I.D.×500mm
Eluent：H2O
Flow rate：1.0
Column temp. ：75℃
7Detection ：RI
7
Injection volume：20μL

Conditions
Column

6

9

10

6
6

10
9

6
6

Other company's column

8
8

7
7

6

Fig. 2-19 Lactose

5

5

5

7

7

6

6

6

Application data of CK06SC

min.

6 Fig. 2-15 Alcohols
6

9
9

4

9

9
9

4

5

5

5

9
9

Conditions
Column ：MCI GEL™ CK08EH, 7.8mm I.D.×300mm
Eluent ：1% H3PO49
9
Temp
：60 ℃
Press
：2.5 bar
Detection：RI
Injection ：10.0 μL

4

MCI GEL™ material list

12
11

4

5

4
4
4

min.

4

4

3

min.

50
40
30
20
10
50

40
30
20
10

2

min.

6

MCI GEL™ CK08EH

8
8
8
8
8

2

4

3

min.

2
2

5

3

3
3

5
5
5

3
3
3

Conditions
Column：MCI GEL™ CK08EH, 8mm I.D.×300mm
Eluent：1% H3PO4（Fig.2-13,2-14）
Flow rate
5 Column temp.：0.6
5 , ambient（Fig. 2-14）：45℃（Fig. 2-13）
Detection：210nm（Fig. 2-13）, RI（Fig. 2-14）

3
3

2
2

：MCI GEL™ CK08EH
8mm I.D.×300mm
Eluent：1% H3PO4
Flow rate：0.6
Column temp.：45℃
Detection：210nm

2

1

3

2
2
2

3

4

Conditions
Column1

2

3

4

Conditions
Column24：MCI GEL™ CK08EH
8mm I.D.×300mm
Eluent：2% H3PO4
Flow rate：0.6
Column temp.：ambient
Detection：210nm：MCI GEL™ CK08EH
8mm I.D.×300mm
Eluent：1% H3PO4
Flow rate：0.6
Column temp.：25℃
Detection：RI

Fig. 2-17 Poly alcohols

11Fig. 2-14 Amino sugars

1
1

1

1

Fig. 2-13 Carboxylic acids

2

1
Conditions
Column1

Fig. 2-18 Carboxylic acids

1
1Fig. 2-16 Chloroacetic acids

1

Application data of CK08EH

Application data of CK08EH

Column selection
guideColumn selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

固相吸着剤

MCI GEL™ column list

SPE sorbent series

Chiral separation
columns

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

MW

Compounds index

MCI GEL™ material list

MW

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index
MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

Compounds index

14
13

10
10
11

Elution volume
Elution volume

10

10

70
60
50
40
30
20
10
102
15
10
102

9
Sorbitol

Ribose

5

9

9

9
9

9
9
9

9
8
Xylitol
Dulcitol

10
10

25

9
9

23

10
： CK08EC…75℃, CK08E…45℃, CK08ES…75℃： 8mm I.D.×300mm
： H2O
： 0.6
： 1% aq. solution＊ ; These sugars, containing Fructose component,： 20µl1010
1010 and CK08EH.
may partially10
be decomposed by CK08ES

9103

Salicin
24

Inositol

8
27

8

Salicin

8

Ribose17
Ribose89Column temp
Column size
Elueunt
Flow rate
SampleInjection vol.

21

103

8

8

8

8

8

8
23

8

52

MCI GEL™ CK02AS…
MCI GEL™ CK02A …

104

MCI GEL™ CK04SS…
MCI GEL™ CK04S …
104
21
Salicin

Erythritol

15

Fucose7
7
Arabinose

7

20

7

MannoseDulcitol

7

Sorbitol
Fucose7
Arabinose

7
7

20
Mannitol

22

7
7

7

7
Fig. 2-21
Galactose
Xylitol

18
Erythritol

DulcitolInositol
AdonitolMannitol

6
6
14
Fructose617

6Fructose
Galactose

20

6Fig. 2-20

6

Calibration
curves of malto-oligosaccharides
6
6

6

6
19

6

7

5

6
Digitoxose

6

Adonitol15
Rhamonse

XyloseInositolAg+
MCI GEL™ CK02AS

5

5

5
Sorbitol5

Rhamonse
Mannose

Erythritol

5Rhamnose

5

Xylose5

Digitoxose
Mannitol
Galactose

Mannose
FucoseNa+
Glucose13

5

Arabinose

5

5

19〜20

MCI GEL™ CK02A

5

L58

5
15〜16

Ag+
Adonitol
12
Glucose14
XyloseXylitol

Na+

4

4
4
Lactulose4444Lactose18

4

13

Digitoxose●Separation ability of each column

10
11
Maltulose

16

MCI GEL™ CK04S

12〜13
MCI GEL™ CK04SS

4

Counter ion

4

Fructose

L58

4
8〜9

4

USP
MCI GEL™ column

17Melibiose
GlucoseMaltulose

3
Maltose11

3
Maltulose

3

15

3

CK02A 20×250

Isomaltose
MaltoseLactose 3

SucroseLactulose
12

3

MaltoseMelibiose

3

Gentiobiose
Isomaltose

3

Cellobiose

Melibiose3

Lactulose2
Sucrose16

2
Isomaltose

Lactose

2

4

3
3

2
2
Trehalose222

9Gentiobiose

10
Gentiobiose

Trehalose

14＊Sucrose
Cellobiose
Trehalose2＊Stachyose

Separation ability（degree of polymerization）

3

CK04SS 10×200

3
CK04S 10×200

2

2

2

The separation mechanism is based on gel filtration chromatography and elution isachieved via simple distilled water. A larger molecule elutes ahead.

13＊Raffinose
Raffinose
Raffinose

1
Stachyose1Melezitose
Melezitose

1

1
1
1

＊Melezitose

1

min
12

1
Stachyose

CK08ES
Ag＋

CK08E
Na＋

CK08EC
Ca2＋

min
8

1

Cellobiose

2

1

applications; oligosaccharides
111

Cation exchange columns

CK04S, CK04SS
CK02A, CK02AS
min
9

2

●Peak retention time for Sugars and Sugar alcohols on various columns〔min〕

40
10

20

30

Fructose
GlucoseMCI GEL™ material list

0
30
20
10
0
30

20
10
0

Sucrose
Dp 6
Dp 4

Dp 3
Dp 5
Dp 4
Dp 3
70

60

50
40
30

20
10
0

60

MCI GEL™ column list

MCI GEL™ material list

50

Dp 5
Dp 2

Fructose

SPE sorbent series

MCI GEL™ column list

40

Glucose
Dp 7

Dp 11
Dp 10
Dp 9
Dp 8

Glucose

Dp 4

Dp 3

Chiral separation
columns

SPE sorbent series

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

30

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

MCI GEL
カラム一覧

Dp 10
Dp 9
Dp 8
Dp 7

Dp 4
Dp 4

MaltoseMaltoseGlucoseDp 2
Fructose

Dp 5

Glucose
Dp 3
Dp 6
Dp 3
Dp 6

Dp 5

40

60

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

固相吸着剤

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

20

20
0

30

20
10
0

Ion chromatography
columns and materials

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

10

30

20
10
0

32
28

24
20
16

12
8
4
0

24
20

16
12
8

4

Dp 4

Glucose

Dp 7

Dp 9
Dp 8

Glucose
Dp 4

Dp 1
Dp 6
Dp 5
Dp 4
Dp 3
Dp 2
Dp 1
Dp 7
Dp 5
Dp 3
Dp 2
Dp 4

Dp 6

Maltose

Dp 1

Dp 7
Dp 5
Dp 4
Dp 3
Dp 2

Maltose

Dp 5

Dp 3
Dp 6

Dp 7

Ion exchange columns
and materials

Ion chromatography
columns and materials

0

Ion exchange columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

0

Dp 3
Dp 5

Column selection
guideColumn selection
guide

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent seriesCompounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

10

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Chiral separation
columns
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

1010

カラム選択の手引き

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

10
10

11

10
Compounds index

Compounds index

10

16
15

min.

：MCI GEL™ CK04S
10mm I.D.×200mm
Eluent：H2O
Flow rate：0.4（Fig. 2-29, 2-30）0.3（Fig. 2-31）
Column temp.：85℃（Fig. 2-29, 2-30）45℃（Fig. 2-31）
Detection
：RI

min.

9
10

10

min.

Conditions
Column

9

9

min.

9

9

9
9

8

8

8

8

8

8

9
9
9
9
（Fig. 2-22, 2-23, 2-26, 2-27）（Fig. 92-24, 2-25, 2-28）

：H2O
：0.4
9
1.0
Column temp.：85℃
Detection：RI
Conditions
EluentFlow rate

7
7
7
7

8
8
8

min.

7
2

7

5

8

2

6

Dp 15
Dp 14
Dp 13
Dp 12
Dp 11

8
8

7

6

5
5

6

5Fig. 2-29 Honey55Fig. 2-25 MCI GEL™ CK02AS
20mm I.D.×250mm

6

6

7

Dp 16

7

6

4

Fig. 2-24 MCI GEL™ CK02A
20mm I.D.×250mm

1

7

6
6

4

6

Dp 12
Dp 13
Dp 14
Dp 15
Dp 16
Dp 17
Dp 18
Dp 19
Dp 20

4

5

1

7
7

6

Fig. 2-30 Jam 5

7

6
6

6

5

5
Fig. 2-31 Fructo-oligosaccharides

5

4

4
4

5

1

5

4

min.
min.

1

3

4

3
3

4
4
4

3
3

2

Application data of CK04S

4

min.

4
min.
min.

3

3

2
2

3
3

2

3

3
3
3

2

2
2
2
2
Dp 9

10mm I.D.×200mm

Dp 6

2
2

1

Dp 6

2

Dp 10
Dp 11
Dp 12
Dp 13

1

1Fig. 2-28 MCI GEL™ CK02AS
1
20mm I.D.×250mm

Fig. 2-27 MCI GEL™ CK04SS
110mm I.D.×200mm
Fig. 2-26 MCI GEL™ CK04S
1
110mm I.D.×200mm

1
1Fig. 2-23 MCI GEL™
1 CK04SS
Fig. 2-22
1 MCI GEL™ CK04S
110mm I.D.×200mm

1

2
7
2Dp
Dp 8

2

Comparison data of authentic malto-oligosaccharides samples

Comparison data of malto-oligosaccharides

MCI GEL™ column list

80

60

Lys
5-hydroxy lysine
pipecolic acid

Ornitinehydroxy proline

5hpa

SPE sorbent series

MCI GEL™ column list

40

His

Arg
Tyr

phe
AlanineValinetert-leucine
isoleucine
leucinenor-leucine-methyl-leucine

Tyr

Chiral separation
columns

SPE sorbent series

proline

Ala

Phe
Ile
Leu
Gly

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Glu

8

16

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

MCI GEL
カラム一覧

Pro

NH3
Val
Met

Lys

0

16
12

8
4

Ion chromatography
columns and materials

Bioseparation columns
and materials

固相吸着剤

20

Cys

Ion exchange columns
and materials

Ion chromatography
columns and materials

Asp
Thr
Ser

Column selection
guide

Ion exchange columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

0Column selection
guide

医 薬 精 密 精 製 用 充 填 カ ラム

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent seriesCompounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

10

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

10

及び充填剤

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

10

生体高分子分離用
充填カラム及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series10

イオンクロマトグラフィー用
充填カラム及び充填剤

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
10

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

10
10

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

10

カラム選択の手引き

Ion chromatography
columns and materials

Ion chromatography
columns and materials

9

9
9

11

9

9

25
20
15
10
5
8
79
6
5
4
3
2
10
7.5
5

8

8

8

8

2.5

pipecolic aicd

10

10

7
7

Conditions
Column ：MCI GEL™ CK10U
6mm I.D.×120mm
Eluent ：0.3M NaSO4 (pH5.7)
Flow：0.5 9Temp. ：60℃
Detection：UV210nm

9

7

8

7
7
7
COOH

7
7
7

0

As for analysis of amino acids by a cation exchange column such as MCI GEL™
CK10U, MCI GEL™ AFR2-PC is recommended as a pre-column. The AFR2-PC
column is very effective to stabilize base line because ammonium in eluent is trappedin this column. The ammonium ion may disturb base line stability. The AFR2-PC
99
9
9
should be installed between an outlet of HPLC pump and an inlet of sample injector. A
gradient elution, commonly used for amino acid analysis, is influenced by HPLC
instrument. So to obtain a satisfactory chromatogram, gradient conditions should be
optimized in accordance with the HPLC equipment.

N
H

8

8

8
8 min.
8

proline

7

6
COOH
N
H

N
H

6
6
5-HPA

6
HO
6
6
6
6

7

6

6
HO

5

Fig. 2-37
5
basic amino acid andaromatic amino acids

5

5

5

Ion chromatography
columns and materials

3

5

4
4

5

Ion exchange columns
and materials

3

Column selection
guide

3

Fig. 2-36
5alkyl amino acid

Fig. 2-35
55cyclic amino acids

4
min.
4

5

Ion chromatography
columns and materials

3

4
4
4
4

Ion exchange columns
and materials

Ion chromatography
columns and materials

Fig. 2-32
amino acids 3
3
3 Protein hydrolyzates

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Column selection
guide

Ion exchange columns
and materials

Column selection
guide

2

Separation of amino acids

COOH
N
H
hydroxyproline

7

8

Column selection
guideColumn selection
guideColumn selection
guide

2

18
17

2

COOH

7

8

9

2

4
4

5

6
6
6

2

Ion chromatography
columns and materials

Ion exchange columns
and materials

2

γ-Aminobutyric acid：MCI GEL™ CK10U
6mm I.D. × 120mm
Eluent：A 0.2N Na-citrate buffer pH3.15
B 0.2N Na-citrate buffer pH3.20
C 0.2N Na-citrate buffer pH4.20
D 0.8N Na-citrate buffer pH9.70
4
4 4-step-gradient
Flow rate：0.5
Column temp.：55℃
Detection：ninhydrin post-column reaction, VIS detector

45

Ion exchange columns
and materials

Column selection
guide

1

min.

3
3

2

Ion chromatography
columns and materials

1

↓

3
3

2

3

Ion exchange columns
and materials

1

2
Ion exchange columns
and materials

1

1

1

CK10U 6×120

Conditions
Column2：MCI GEL™ CK10U
6mm I.D.×120mm
Eluent：0.3M Na-phosphate pH5.0
Flow rate：0.5
Column temp.：40℃
Detection：210nm2
Sample：1. Valine
2. β-Alanine

1

Conditions
Column1
1High cross linkage cation exchange column
applications; amino acids, amines, etc

CK10U

3

2

2

：MCI GEL™ CK10U
6mm I.D.×120mm
Eluent：0.2N Na-Citrate buffer pH5.2
Flow rate：0.5
Column temp.：55℃
Detection：570nmConditions
Column1
Fig. 2-33 Valine, β-Alanine21
1Fig. 2-34 γ-Aminobutyric
acid
1

1

Separation of amino acids

2Compounds index

20
10
0

MCI GEL™ material list

Compounds index

分離例化合物リスト

Compounds index

60
50
40

Citric acid

Gluconic acidMalonic acid

MCI GEL™ column list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

MCI GEL™ material list

30

Acetic acid

SPE sorbent series

MCI GEL™ column list

Tartaric acid

Chiral separation
columns

SPE sorbent series

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index
MCI GEL™ material list

Malic acid

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

Lactic acid

100
80
60
40

20

40
20

Glucose

Ascorbic acidPyruvic acid
Malic acid
Succinic acid
Citric acid

Formic acid
Lactic acid
Gluconic acid

Melibiose
Fructose
FucoseMannoseXyloseGalactose

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

ア ミ ノ酸 D L 分 離 用
充填カラム

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Formic acidIon chromatography
columns and materials

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

MCI GEL™ material list

20

Ion chromatography
columns and materials

生体高分子分離用
充填カラム及び充填剤

Tartaric acidAcetic acidAcetic acidIon chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

Lactic acidAcetic acid

MaltoseLactoseRhamnose
RiboseCellobiose

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

8

MCI GEL™ column list

10

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

0

Deoxyribose

Column selection
guide

Ion chromatography
columns and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Chiral separation
columns

SPE sorbent series

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent seriesCompounds index0Column selection
guideColumn selection
guide

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

カラム選択の手引き

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

10

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

10
10
10

20
19

10
11

9

9

10

min.

9

9

9

10

7

10
9
9

9
9

10

7

8

8

8

8

min.

7

6

8

8

9
9

7
7
7
7
7

9
9

6
6

8

8

6Fig. 2-42 Carboxylic
6 acids
6

8
8：MCI GEL™ CA08F
4.6mm I.D.×250mm
Eluent：0.6M Na2SO4 pH3.0
Flow rate：0.5
8Column temp.：60℃
Detection：210nm6

7

Conditions
Column7：MCI GEL™ CA08F
4.6mm I.D × 250mm
Eluent：0.1M NaH2PO4 pH3.3
7：0.4
Flow rate
Column temp.：55℃
Detection：210nm7

6
6

7
Conditions
Column6

6

5

50 5 60

40
30
20

10

6

Fig. 2-39 Carboxylic acids

40min. 5

5

6

min.

4

Conditions
Column
3

5

4
4

3

5

5

5
5
5
5
5

3
3

5

4
4
4
4
4

1

4
4

2

3
3

1

3
3

2
Fig. 2-38 Sugars

1

3
3

2
2

1

3

2
2
2

Application data of CA08F

3：MCI GEL™ CA08F
34.6mm I.D.×250mm
Eluent：A 0.15M Borate buffer pH7.5
B 0.5M Borate buffer pH9.5
C 0.6M Borate buffer pH9.5
D 0.7M Borate buffer pH8.5
4-step-gradient
Flow rate：0.5
Column temp.：65℃
Post4column reaction
4
Reagent：2.5% Boric acid,
5% Monoethanolamine pH7.9
Flow rate
：1.0
Temp.
150℃
Detection：Fluorescence Ex 360nm, Em 440nm

2

2

2
2

1

2

Conditions
Column ：MCI GEL™ CA08F
lot 5F1502
Eluent ：0.6M Na2SO4 8 (pH4)
Flow rate：0.5
Temp ：60℃
Detection：210nm
Conditions
ColumnMCI GEL™ CA08F packed column has been designed for the analysis of nucleotides, sugars, and organic acids byanion exchange chromatography mode.
This column will provide excellent separation and short analysis time.

Fig. 2-40 Carboxylic acids

1
1
1
1

applications; sugars, carboxylic acids, nucleotides

Anion exchange column

CA08F：MCI GEL™ CA08F
4.6mm I.D × 250mm
Eluent：0.6M Na2SO4 pH2.0
Flow rate：0.5
Column temp.：60℃
Detection：210nm2

1
1

Fig. 2-41 Organic
acid
1

1

Application data of CA08F

2

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

40
Compounds index

30

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

3'-GMP

5'-GMP
5'-UMP

3'-UMP

5'-IMPMCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index
MCI GEL™ material list

20

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

2'-AMP

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

3'-AMP

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

5'-AMP

50
40
30

20
10

80

60
40
20
0

Galactose
MannoseRhamnose
5'-GTP
5'-ATP
5'-ADP
TPN

5'-CMP

Melibiose
XyloseFructose
Uracil5'-AMP

2'-AMP

3',5'-Cyclic AMP
AdenineThymineCytosine

LactoseRiboseAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

9Compounds index

10

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

5'-CMP

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

83'-CMP

Ion chromatography
columns and materials

Ion chromatography
columns and materials

GlucoseIon chromatography
columns and materials

Deoxyribose

Cellobiose
MaltoseIon chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

2'-CMPIon exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns0

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
0

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

Column selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

10
10

9

10
10

11
10

min.

7

9

9

7

10
9
60 min.
40

9
20
0

9

9
9
9
9
9
9

6

8

8

8

8

8
8
8
8
8
8

6

Fig. 2-46 Human urine

7
7
7

6

：MCI GEL™ CDR10
4.6mm I.D.×250mm
7Eluent：A 0.006M Acetate buffer pH4.4
B 6M Acetate buffer pH4.4
A→B 60min. linear gradient
Flow rate：1.0
Column temp.：60℃
Detection：254nm

7

7
7

6
6

Conditions
Column

7

6
min.

7
Conditions
ColumnFig. 2-44 Mono-nucleotides

6
6

6

6

5

5

5

5

5

5
5
5

2

5

4

5

2

5

4
4

Ion exchange columns
and materials

Ion exchange columns
and materials

2
2

min.

4
4
4
4

Column selection
guide

Ion exchange columns
and materials

2

イオンクロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

2

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

2

Column selection
guide

3

カラム選択の手引き

Column selection
guide

Ion exchange columns
and materials

2

5

3
3
3

Column selection
guideColumn selection
guide

1

Column selection
guideColumn selection
guide

1

22
21

1

2

4
4
4

4

10
10
10

1

Fig. 2-45 Sugars

3

3
3：MCI GEL™ CDR10
4.6mm I.D.×250mm：1M Acetate buffer pH3.3
Eluent：1.2
Flow rate
Column temp.：60℃
7：254nmDetection

7

8

1

Packing material of MCI GEL™ CDR10 column is based on a high porous polystyrene functionalized with aquaternary ammonium anion exchange resin. Since a high porous type ion exchange resin is rigid, CDR10 allows usageof aggressive gradient elution, for example water to 6M of acetate buffer gradient. MCI GEL™ CDR10 is highly
recommended for rapid analysis of physiological fluids like urine and blood.

3

3：MCI GEL™ CDR10
4.6mm I.D.×250mm：A H23O
EluentB 6M Acetate buffer pH4.4
A→B 30min linear gradient
Flow rate：0.5
Column temp.：60℃
Detection：254nmFig. 2-43 Nucleic acids and related substances

Conditions
Column

3

6
6
6

1

2

4

5

1

High porous type anion exchange column

CDR10

4

2

Conditions
Column 2 ：MCI GEL™ CDR10
4.6mm I.D.×250mm
2
Eluent：A 0.15M Borate buffer pH7.5
B 0.6M Borate buffer pH9.5
A→B60min linear gradient
Flow rate：0.5
Column temp.：65℃
Post column reaction
Reagent
Boric acid, 5% Monoethanolamine pH7.9
3 ：2.5%
Flow rate
：0.5
3
Temp.
：150℃
Detection：Fluorescence Ex 360nm, Em 440nm

11Application data of CDR10

1
1

1

1

Application data of CDR10

2

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL
カラム一覧

MCI GEL™ column list

Guanosine

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

MCI GEL充 填 剤一覧

MCI GEL™ material list

Cytidine
Adenosine

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

UridineAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Chiral separation
columns

Chiral separation
columns

固相吸着剤

Dimethylamine

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

SPE sorbent series

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Trimethylamine

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

医 薬 精 密 精 製 用 充 填 カ ラム

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Ammonia

Ion exchange columns
and materials

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Methylamine

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

カラム選択の手引き

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

10
10
10

10

11

10
Compounds index

SCA04 4.6×150 PEEK

Column selection
guideColumn selection
guideColumn selection
guide

8 min.
4

Fig. 3-3 Monovalent cations in rain

24
23

8 min.
4
8 min.
4

9

9

9
10

K

9

K

9
9

Conditions
Column：MCI GEL™ SCK01 6mm I.D.×50mm
Eluent：5mM HNO3
Flow rate：1.0
Column temp.：40℃
Detection：Conductivity（Fig. 3-1, 3-2, 3-3, 3-4, 3-5）254nm（Fig. 3-6）

10

MCI GEL™ SCA04

Anion chromatography column

9
9
9
9
9

8

8

8

Na

7
7

7
7
7

9
A pre-column, MCI GEL™ SCA-PC is recommended for prevention of contamination to the SCA04 column when the
VA/MDEA eluent is used. The SCA-PC is effectively prolong SCA04 column life. The SCA-PC should be installed
between an outlet of HPLC pump and an sample injector.

77

8

12 min.
12 min.
8
4

7
7

Fig. 3-6 Nucloside

Fig. 3-5 Sports drink

Fig. 3-4 Monovalent cations in tap waterNa

9■Note:

6

8 min.

7

8

6

4

Packing material of MCI GEL™ CHK45/C05 is made of crosslinked polymethacylate functionalized with carboxylic
acid. By use of simple eluent system, MCI GEL™ CHK45/C05 can separate both monovalent and divalent cations in tap
water, river water and other environmental water samples.

7

7

6

MCI GEL™ CHK45/C05

8

8

6

Cation chromatography Column

8

4

6

6

Packing material of MCI GEL™ SCA04 is based on a hydrophilic viniyl polymer matrix functionalized with quaternaryammonium group and particle size of 5 μm. A solution of potassium hydrogen phthalate and a vanilic acid
(VA)/N-methyldiethanolamine (MDEA) solution both can be used as a mobile phase. The unique VA/MDEA eluent, is
8 in 14 minutes without 8system peak.
8
8 allows users to determine
developed for8the SCA04 column, which
7 standard anions

6
6
6

K

When using the MCI GEL™ SCK01 column for monovalent cations, it is recommended that a pre-column, MCI GEL™
SCK-PC, be used to trap heavy metals which might otherwise poison the SCK01 column resulting in a rapid loss of
capacity and chromatographic performance.

7

6

Na
NH4

6

Cs

6
Rb

5

5

5

5

5

5
5
5

3

NH4 K

5

5
Li
Na

5

MCI GEL™ SCA-PC

6

4■Note:

Pre-column
for anion analysis

5

4

5

MCI GEL™ SCA04

2

4
4
4

Anion analysis

3

The MCI GEL™ ion chromatography columns are based on surface functionalized cation and anion exchange resins
designed for non-suppressed ion chromatography applications. The non-suppressed ion chromatography is an analysis
technique of cations and anions with combination of a packed column of low capacity ion exchange resin and low
3
3
3
3
3
concentration of electrolyte solution as an eluent. The advantage of the ion chromatography is that several ions can beanalyzed by only one injection with free of complicated sample pre-treatment.

4
Packing materialis crosslinked polystyrene
functionalized
This column is
4 with sulfonic acid. 4
44 of MCI GEL™ SCK01
4characterized by excellent resolution and rapid analysis for monovalent and divalent cations. Standard monovalentcations like Li+, Na+, NH4+, K+, Rb+, Cs+ and simple amines such as mono-, di- and trimethylamine can be resolved
using a nitric acid solution as eluent. Divalent cations, such as alkaline earth metals and transition metal elements, can be
efficiently resolved using tartaric acid and complexing reagent such as ethylene diamine to selectively elute the metals
from the column.

Application data of SCK01

3MCI GEL™ CHK45/C05

3

3

Stainless steel
columnCation analysis

3Fig. 3-2 Amines

Fig. 3-1 Monovalent cations

MCI GEL™ SCK01

Cation chromatography column

2

MCI GEL™ SCK-PC

2

34.6mm I.D×150mm

Stainless steel
column4.6mm I.D×150mm

Pre-column
for cation analysis○Cation chromatography column MCI GEL™ SCK01○Cation chromatography column MCI GEL™ CHK45/C05
2
2
2
2○Anion chromatography
column MCI GEL™
SCA04 2

4
4

1

MCI GEL™ SCK01

2

3

1

Cation analysis

2

1*USP L31 column

Stainless steel
column1

8mm I.D×10mm

2

6mm I.D×50mm

1

PEEK column

2

4.6mm I.D×150mm

Stainless steel
column1

1

3 Ion chromatography columns and materials

2

1
Stainless steel
column1
6mm I.D×50mm
11
MCI
1 GEL™ SCK01

1

Cation analysis

Column list

16
12

MCI GEL™ material list

8
4
16
12
8
4
16

MCI GEL™ column list

MCI GEL™ material list

12

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

8

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ material list

4

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

12

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

20
16

12
8
4

36

32
28
24

20
16
12
8
4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

10

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

固相吸着剤

Chiral separation
columns

Bioseparation columns
and materials

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

Compounds index

8

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

SPE sorbent series

MCI GEL™ column list

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

6

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

4

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

2

Column selection
guide

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

10

AMAL 7

Column selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion chromatography
columns and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
10

26
25

10
10

11
10
10
10

9
min.

9

min.9

10

2ppm

6ppm

15ppm
5ppm

8ppm
NO3-

min. 9

9

10

10

Ca2+

Na
NH4+

(Data provided by Professor Yokoyama of Yokohama National University)

8
8
8

9

10

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

7

8

9
9
9
9

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

7

8

9
9

Column selection
guide

Ion exchange columns
and materials

7

9

8

8

8

8
19ppm
SO42-

8

7

8

+

7
7

8

K+

7
22ppm

7
7

Li+

6

5

5

5
5
5 Mono, Divalent cations
5
Fig. 3-10

7

7

Mg2+

6

4

59ppm

6
6
6

4

Application data of CHK45/C05

Fig. 3-13 Rain

Conditions
Column：MCI GEL™ CHK45/C05（SUS)
4.6mm I.D.×150mm
Eluent：4mM H2SO4
Flow rate ：1.2
Temp.
：40℃
Detection ：Conductivity
6
6
Sample 6inj：100μL
Li（0.5ppm)，Na（1ppm），NH4（1ppm)，K（4ppm），Mg（4ppm），Ca（4ppm）

5

4

7

6

C; After 38 hours

66

B; After 4 hours

5

5

5

5

6

6

min.

4
4

4
4

A; Beginning of rain fall

7

5

4

4

4 min.

16 min.

12
8
4
8 min.

71ppm

min.

4

（System peak）

4
4

1
7
1

4

5

Column selection
guideColumn selection
guide

3

4

3
3
3

4

3
3
3. C
3
4. NO25. Br6. NO37. SO42-

3 3
3
3

Sr
Cd

Ba

Mn Ca
Co

Zn

4

3

3

2

6

5

2

Sr

2
2

5

2
：MCI GEL™ SCA04
4.6mm I.D.×150mm
Eluent：3mM VA 2.8mM MDEA pH6.2
Flow rate：1.2
Column temp.：40℃
Detection：Conductivity
Sample：1. F3
2. H2PO4-

2
2

2

2

：MCI GEL™ SCA04
4.6mm I.D.×150mm
Eluent：3mM KHP
Flow rate：1.2
Column temp.：40℃
Detection：Conductivity
Sample：1. F2. C
3.
3NO24. Br5. NO36. SO42-

Conditions
Column
6

2

2
2
2

Ca

2

Mg
Ca
Mg

1

2

1
Fig. 3-12 Standard anions
eluent ; Potassium hydrogenphthalate

Fig. 3-11 Standard anions
eluent ; VA/MDEA

1
1
Fig. 3-9 Divalent
1 cations1Fig. 3-8 Transition
metals1
Fig. 3-7
1 Alkaline earth metals
11Conditions
Column1

11

Application data of SCA04

Application data of SCK01

Compounds index

40

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

Compounds
index
分離例化合物リスト

MCI GELMCI GEL™ material list
充 填 剤一覧

36
32

Compounds index

MCI GEL™ material list

Compounds index

28

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GELMCI GEL™ column list
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

24

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

20

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

Compounds index
MCI GEL™ material list

Compounds index

MCI GEL™ material list

MCI GEL™ material list

Compounds index

MCI GEL™ material list

16

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

Chiral separation
columns

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

12

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

20
16
12
8
4

20
16
12

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

Compounds index

8

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

4

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
Bioseparation columns
Chiral separation
columns and materials
生体高分子分離用
医薬精密精chromatography
製 用 充 填 カ ラム
ア ミ ノ酸 D L 分 離 用
and materials
columnsfor pharmaceutical applications
充填カラム及び充填剤
及び充填剤
充填カラム

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

8

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography

イオンクロマトグラフィー用
columns and materials
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

4

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

10

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

10

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
10

Ion exchange columns

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

10

9

3

Ion chromatography
columns and materials

10

9
9

28
27

11
10
10
10

9

9

9
9
9

10

min.

10

9

10

9
10

9
9

9

8

8

8

8

8

8

8
8

イオン交換クロマトグラフィー用and materials
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

7

Nitrate

9

7
7

8
8

7

MCI GEL™ CQP30

7MCI GEL™ CQP10：MCI GEL™ SCA04
4.6mm I.D.×150mm
Eluent：3.8mM VA 2.1mM MDEA pH4.5
7 rate ：1.2
7
Flow
Column temp.：40℃
Detection：Conductivity

78

Chloride

8
8

7
―

7

―
Size exclusion

L38

7

―

7

―

Size exclusion

7
L25

Size exclusion
L37, L38

Anion exchange

Quaternary ammonium(QA)
XtalSpeed™ Q01

766

MCI GEL™ CQP06

6
carboxymethyl(CM) 6
Cationexchange
6―

6―
XtalSpeed™ DA01

6

XtalSpeed™ SP01

6

XtalSpeed™ CM01

Sulfopropyl(SP)―Anion exchange

33Cation exchange

3
3

USP
Column name

6

6

5

5
min.

5

5
5
5
5

6
6
6

55ppm
HCO3-

Conditions
ColumnDiethyl amino ethyl(DEAE)

6

5

5

5

4

4
4
8ppm
NO3-

4

min.

4

4
4

3

4

5

Fig. 3-16 Instant coffee

5Functional Group
Separation mode

4
XtalSpeedTM series are ion-exchange columns used for protein purification. High-quality target proteins are
obtained with this column at a high recovery rate. XtalSpeedTM series are used for both analytical and preparative
purpose in protein crystallography and NMR research.
XtalSpeedTM series are also used for antibody variant analysis and protein isoform analysis.

4
4

5

5

4

MCI GELTM CQP series are used for size-exclusion chromatography.

4

2

4

MCI GELTM bioseparation columns are based on a hydrophilic, wide-pore, and rigid polymer designed foranalytical chromatography of proteins, peptides, enzymes, and other biomolecules.

23ppm
SO42-

2

Conditions
Column3

guideColumn selection
guide

1

selection
カラColumn
ム選択の手引き

Column selection
guide

1

1

3
3

3
3

3

2

Ion exchange columns
and materials

Column selection
guide

1

Ion exchange columns
and materials

Column selection
guide

1

Ion exchange columns
and materials

Column selection
guide

1

3
3
3

2

1

Fig. 3-15 Sulfur compounds

Bioseparation columns

2222○Size-exclusion
chromatography
columns
MCI GEL™ CQP series

2○Ion-exchange chromatography columns
XtalSpeed™ series

1

16ppm

：MCI2GEL™ SCA04
4.6mm I.D.×150mm
Eluent：4mM KHP pH4.1
Flow rate：1.2
Column temp.：40℃
Detection：Conductivity
Sample：1. SO422. S2O323. SCN-

1
1Fig. 3-14 River water

2

1

1
1

1

Conditions（Fig. 3-14, 3-15）
2 GEL™ SCA042：MCI
Column4.6mm I.D.×150mm
Eluent：3mM VA 2.8mM MDEA pH6.2
Flow rate：1.2
Column temp.：40℃
Detection：Conductivity

22

1

4 Bioseparation columns and materials
Application data of SCA04

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

固相吸着剤

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

kinaseBioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Impurities

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Bioseparation columns
and materials

VIS 415nm(uV)

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

kinaseIon chromatography
columns and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

VIS 415nm(uV)

Column selection
guide

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Impurities

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Bioseparation columns
and materials

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

Compounds index
MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

Compounds index

MCI GEL™ material list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

SPE sorbent series

SPE sorbent seriesCompounds index10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

カラム選択の手引き

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
10

Column selection
guideColumn selection
guideColumn selection
guide

Ion chromatography
columns and materials

Bioseparation columns
and materials

10
10

2

Ion exchange columns
and materials

Ion chromatography
columns and materials

10

10
10

2

Ion exchange columns
and materials

10

10

11

Conditions
Eluent ： Buffer A:50mM HEPES-NaOH(pH7)
Buffer B:50mM HEPES-NaOH(pH7),1M NaCl
Flow rate ： XtalSpeedTM DA01 :0.6
Competitor’s Column Q:1
Gradient ：0-40%B（0-400mM NaCl)/40CV
Sample ：50 micro grams of human kinase

9

9
40

38
36
34

9
32

9 42
40
38
36
34

10

32

9
9
0-047-24

90-047-23
Φ7.5mm×100mm

9Φ11.5mm×100mm

Quaternary ammonium
(QA)

PEEK

Φ4.6mm×100mm

30

9

928
9

9

8

Q01

0-047-33
Φ7.5mm×100mm

0-047-22

8
8
8

9

CM01

Φ4.6mm×100mm

0-047-34

Carboxymethyl
(CM)

PEEK

0-047-32
Φ4.6mm×50mm

8

Φ4.6mm×50mm

0-047-317
Φ11.5mm×100mm

7 0-047-03
7DA010-047-21

8

8

8

8

8

8

7

Φ7.5mm×100mm

770-047-02

PEEK

Diethylaminoethyl(DEAE)

0-047-04
Φ4.6mm×100mm

78

Φ11.5mm×100mm

Column Q (4.6*100mm)

XtalSpeedTM DA01 (4.6*50mm)

7
7
7

20
min
16
12
8
4
0
-1.00E+04

20
min
16
12
8
4
0
-1.00E+04

7

7
Fig. 4-3 Comparisonof loadability
7

0.00E+00
0.00E+00
0-047-01

6
1.00E+04

Hb A1c6
1.00E+04

66
6

Φ4.6mm×50mm

0-047-13
Φ7.5mm×100mm

65
6.00E+04

6

6 3.00E+04

Hb A0

8.00E+04

6

0-047-12
Φ4.6mm×100mm

6

3.00E+04

55

7.00E+04

5

Hb A1c2.00E+04

6

4.00E+04

4.00E+04

Sulfopropyl
(SP)
PEEK

SP01

0-047-14
Φ11.5mm×100mm
6

5.00E+04

5.00E+04

0-047-11

Diabetic patientAble-bodied person

Column list

5
5

Column selection
guideColumn selection
guideColumn selection
guide

4

30
29

4

2.00E+04

64

6.00E+04

55Functional Group

HousingCode5

5
Column size

Column name5

4

Conditions
Column ：XtalSpeed™ SP01
50 x 4.6mmI.D
5 Bis-Tris-HCl
Eluent ：A, 20mM
(pH6.0)
B, A + 1M NaCl
Flow rate ：0.5
Gradient ：5 - 40%B over 30min
Detection：VIS 415nm
Temperature：35℃

Φ4.6mm×50mm

9.00E+04

Hb A0

8.00E+04

4
4

5 7.00E+04

4
4
4

3
3

9.00E+04

4

Fig. 4-2 Analysis
of Hemoglobin A1C4

4

4

30 min
25

20
15
10

5
0
30 min

15
10
5
0

3

Conditions
Column ：XtalSpeed™ SP01
100 x 4.6mmI.D
Column A (250 x 4mmI.D)
3
3
Eluent ：A, 20mM Na phophate (pH7.0)
B, A + 1.0M NaCl
Flow rate ：0.529
for XtalSpeed and 1.0
for ProPac
Gradient ：(A), 2.5-20.0%B over 30min + 20.0-100%B over 5min(C), 2.5-5.0%B over 30min + 5.0-100%B over 5min

3

2

2
2

Ion exchange chromatography columns

3

2

XtalSpeed™ SP 01
column A

2
2 They have been designed
2 especially
2
XtalSpeedTM 2series columns are ion-exchange
columns used2for protein purification.
for protein crystallography and NMR research, and enable to purify target proteins with high quality at a high recovery
rate and in a very short time and obtain protein crystals for further analysis.
We developed hydrophilic and chemically stable polymer layers based on highly porous polymer beads, reducing
non-specific binding to the lowest level.
To eliminate other interactions and allow target proteins participate only in the ion-exchange mechanism, this column
was able to separate
similar proteins3that other columns never3
3
3 succeeded to separate.
3
Even under large sample loading, this column maintains excellent selectivity. Taking these aspects into consideration,
XtalSpeedTM series can be used as preparative columns for protein.
XtalSpeedTM SP01 is also used for antibody variant analysis.
2

1
1

3

XtalSpeed™ SP 01
column A

1
1

1

25

1
1

1

1

Ion exchange chromatography columns

XtalSpeedTM series

20

1

1

1

Fig. 4-1 Analysis of Rituximab

1

Application data of XtalSpeed™ series

4Column selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Chiral separation
columns

固相吸着剤

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL充 填 剤一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL
カラム一覧

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

Compounds index10

生体高分子分離用
充填カラム及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent seriesCompounds index10

イオンクロマトグラフィー用
充填カラム及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Ion chromatography
columns and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

MCI GEL™ column list

SPE sorbent seriesCompounds index

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

MCI GEL™ column list

SPE sorbent series

10

Column selection
guide

Ion exchange columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

カラム選択の手引き

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

10

9

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

10
10
10

9

11

40 min.

30
20
10
0
30 min.
20

10

9

0

9

9

9

9
10

9
9
9

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

32
31

8
8
8

9

8
8
8
8

7

9

8

8

7

7

4.0mm I.D.×50mm

1

8

8

8

9

4

7
7

3

7
7
7
2

7
7

MCI GEL™ CQP30G

20

7
7

4.0mm I.D.×50mm

6

60
10
7.5mm I.D. ×600mm

12
10

6
6

〜1×1067.5mm I.D. ×600mm

6
6

6000

L25

2

MCI GEL™ CQP10G

Fig. 4-6 Separation of protein mixture〜1×1045
L37, L38

Packing materials

5
MCI GEL™ CQP06

5 7.5mm I.D. ×600mm 5 10L38

64.0mm I.D.×50mm

MCI GEL™ CQP06G〜1×103

Column dimensions Particle size Pore size
[nm]
[μm]

Conditions
Column：MCI GEL™ CQP06 7.5mm I.D.×600mm
Eluent：H2O
Flow rate：0.8
6
6
Column temp.：ambient
Detection：RI
Sample：1. 5% Gluconic acid
2. 5% Glucose

Column 6
dimensions

10000

USP

6
Conditions
Column：MCI GEL™ CQP30 7.5mm I.D.×600mm
Eluent：14mM
Flow rate：1.0
6
Column temp.：ambient
Detection：280nmSample：1. Ferritin（MW440,000）
2. Ovalbumin（MW43,000）
73. Myoglobin（MW17,500）
4. Cytochrome （c MW12,400）
MCI
6 GEL™ column

Exclusion limit
[PEG]

5

Theoreticalplates number[TP／column]

MCI GEL™ column

15●Guard columns

6●CQP series

Fig. 4-7 Separation of gluconic acid and glucose

5

5

5

5

4
4

6000

MCI GEL™ CQP30

20 min.

10
0
20

15

4

10

4

MCI 5
GEL™ CQP1044Column list

4

5

3

Elution volume

4

3

5

4
4

CQP 06

4

3

3

10

4

3
3

102

CQP 10

3
3
104

3

MW

3

4

Column selection
guideColumn selection
guide

1

1

3

3

3
3

2
2

2
CQP 302

1Size exclusion chromatography columns

3

2

2

2

1

Size exclusion chromatography is a liquid chromatographic technique which separates solute molecules according totheir size in solution.
The column is 2packed with porous particles
and separation takes
2 place as a result of 2the differential
22
solute distribution outside and within the pores of the packing material. Solute molecules which are larger than the poresof the packing material will be excluded and therefore will elute first and have a lower retention time than the smaller
one. The CQP series columns based on a hydrophilic polymer are designed for analysis of water soluble polymers suchas oligosaccharides and PEG, etc.

2

1

1

105

1
：MCI GEL™ CQP06
MCI GEL™ CQP10MCI GEL™ CQP30
7.5mm I.D.×600mm
Eluent：H2O
Flow rate：1.0
Column temp.：ambient
Detection：RI
Sample：PEG2100μl inj.

1

Conditions
Column1

101

Conditions
Column：MCI GEL™ CQP30 7.5mm I.D.×600mm
Eluent：H2O
Flow rate：1.0
Column temp.：25℃
Detection：RI
Sample：1. PEG 145,000
2.
40,000
3.
6,000

1

1

Aqueous size exclusion columns

CQP series

61Fig. 4-5 Separation of PEG mixture

Fig. 4-4 Calibration curve

1

Application data of CQP series

4Column selection
guide

Ion exchange columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6

4

7
CHP20/C10

4.6×150

10

10

4

9

4

Weak cationexchange10
group

CHK45/C05
105

4.6×150
20×200104.6×150

89Compounds index

CHPOD/C04

9

7

Compounds index

10Compounds index

Compounds index

CMG20/C10

4.6×150
20×150
4.6×150
9 4.6×250
10×25020×150
20×2508

L21

MCI GEL™ material list

CMG20/C04

4.6×150

Full range

MCI GEL™ material list

4

MCI GEL™ material list

CHK40/C04

4.6×150
20×200
4.6×150
4.6×250
8 10×150
20×150
20×2507

USP

MCI GEL™ column list

8

10×25020×150
20×250

MCI GEL™ column list

4

7 4.6×250
MCI GEL™ column list

CHP07/C04

CHP07/C10

4.6×150
20×150

pH range

SPE sorbent series

CHP20/C04

Column size
[mm I.D.×mm]

SPE sorbent seriesParticle size[μm]

SPE sorbent series

Product name

C18

*CHP20/C04, CHP20/C10: USP classification is L21

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

9

None

6

MCI GEL™ material list

11

Cation exchange group

5

6

MCI GEL™ column list

Methacrylates

8

Compounds index

分離例化合物リスト

10Br

MCI GEL™ material list

MCI GEL充 填 剤一覧

9

MCI GEL™ column list

Styrene Divinylbenzene

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

None
7

MCI GEL
カラム一覧

9

SPE sorbent series

7

4

6

Column list
SPE sorbent series

Functinal group3

Chiral separation
columns

Chiral separation
columns

Matrix Type

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

固相吸着剤

6

Bioseparation columns
and materials

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

10

Compounds index

10

C＝Column
P＝Material

MCI GEL™ material list

Compounds index

10Particle size

6

7

8

2

MCI GELTM
3 CHP07/C04, C10 > CHP20/C04, C10 > CHPOD/C04 ≥ ODS columns ≥ CMG20/C04, C10
3
3 their superior chemical
Polymer columns for HPLC, withresistance, can 3be used with various 3mobile phases ofbroad pH range, acidic through alkaline. They have the following advantages due to their high hydrophobicities:
1）In reverse phase chromatographic methods to separate acidic or alkaline compounds, eluents that can suppress theionic properties of such compounds are generally used. Polymer columns can be applied in these cases where ODS
columns would be unsuitable.
42）Some extremelyhydrophilic compounds, e.g., oligosaccharides, can be separated using strongly hydrophobic
CHP07/C04 or CHP07/C10 columns.
44443）Polymer columns can be washed with acidic and/or basic solutions in case of contamination.
Polymethacrylate columns, CMG20/C04 and CMG20/C10, can be applied both for reverse phase and normal phase
chromatography.
Modified polystyrene packing, CHK40/C04, is a mixed-mode type material; both hydrophobic and hydrophilicinteractions
5 occur between the packing material surface and the analytes. This material is useful for compounds thatare difficult to separate using existing ODS or other polymer-based columns. This column is also used in the normal
5555phase mode and shows a unique separation
profile.
All polymeric columns exhibit superior stability and yield in comparison to ODS columns, which may have freesilanol groups even when end-capping agents have been used.

6 ●CHP column series
MCI GEL™ column list

MCI GEL™ material list

Compounds index

109Compounds index

Compounds index

10

9

MCI GEL™ column list

MCI GEL™ material list

MCI 9GEL™ CHP20/C04
9
9The hydrophobicities of the columns are in the following orders:

医 薬 精 密 精 製 用 充 填 カ ラム

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

●Description of MCI GELTM columns and materials

8

2

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

8

1

TM
Polystyrene packing: MCI
CHP20/C04,
CHP20/C10
2 GEL
2
2
2
Modified polystyrene packing: MCI GEL TM CHP07/C04, CHP07/C10, CHK40/C04
Polymethacrylate packing: MCI GEL TM CMG20/C10
Modified polymethacrylate packing: MCI GEL TM CHPOD/C04, CHK45/C05

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

8

TM

Column selection
guide

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

MCI GEL™ column list

8

TM

1

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

The MCI GEL packing materials are based on the same chemistries offered in the Diaion and Sepabeads syntheticTMadsorbent resins.
like DiaionTM7 HP series and Sepabeads
SP series, are widely
7 These polymer chemistries,
7
7
7 used anddocumented in the biopharmaceutical industry for fermentation extraction, the food industry and in industrial
chromatographic separations. The MCI GELTM packing materials are available as packed columns for analyticalapplications, and as bulk packing materials for analytical, preparative and production chromatography applications.
TM

5

1

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns

widespread thanks to the many advantages of the polymer matrix like excellent selectivity, the absence of specificadsorption which is found commonly with silica-based packing, operability in a wide pH range and good chemical
stability due tomaterials. The 5MCI GELTM partition chromatography
columns5 are based on
5 the inert nature of polymeric55a polystyrene and polymethacrylate porous polymer. As RP columns, they are applied to the separation of a wide varietyof organic compounds, both in the isocratic and gradient elution mode. The compounds include peptides, insulin, small
molecule APIs, nutraceutical compounds, water-soluble vitamins and nucleotides. As NP columns, they are used in theseparation of various carotenoids, fat-soluble vitamins, steroids, and food additives. These columns tolerate variousorganic solvents
6 like hexane, heptane,
6 methylene chloride, and6 alcohols.
66
As NP columns, they are used in the separation of various carotenoids, fat-soluble vitamins, steroids, and food additives.
Various organic solvents like Hexane Heptane, methylene chloride and alcohols can be used.

Matrix type4

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

MCI GELTM specializes in polymer-based packing materials. The use of polymer-based columns has become more

8

3

Column selection
guide

Ion chromatography
columns and materials

Bioseparation columns
and materials

High performance liquid chromatography relies on one of the following physical phenomena for efficient separation ofsolutes: partition, adsorption, size exclusion, or ion exchange. Of these, partition chromatography is the most commonly
3 in partitioning between
3
3 based on their difference
used method,3and it separates solutes
a stationary phase3and a mobile
phase. This technique has currently become the mainstay in industry for the separation of organic compounds such as
pharmaceuticals, agricultural chemicals, and other intermediates. Practically, partition chromatography can be performedin two different modes depending on the relative polarities of the stationary and mobile phases. In the normal phase (NP)mode, the mobile phase is less polar than the stationary phase while the situation is reversed in the reverse phase (RP)
4 the stationary phase.4
4
4mode, where4the mobile phase is significantly
more polar than

1Analytical and preparative chromatography columns andmaterials for pharmaceutical applications

MCI GELTM CHP series are suitable for RP and NP chromatography. There are four kinds of columns of varioushydrophobicities; porous polystyrene, modified porous polystyrene, polymethacrylate, and modified porous
polymethacrylate. This range of packing materials offers tremendous scope for a proper selection of columns
based on the properties of the target compounds.

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Separation mechanism of CHP series

1

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

21

イオンクロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

2

CHP column series
イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

2

カラム選択の手引き

Column selection
guide

33

2

Compounds index

Compounds index

10

2

MCI GEL™ material list

MCI GEL™ material list

9

○Polymeric partition chromatography columns and materials
MCI GEL™ CHP series

MCI GEL™ column list

MCI GEL™ column list

81

SPE sorbent series

SPE sorbent series

71Chiral separation
columns

Chiral separation
columns

6

1

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

1

Bioseparation columns
and materials

Bioseparation columns
and materials

4

1

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

1

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

1

and preparative chromatography columns
5 Analyticaland materials for pharmaceutical applications

5

10

10

2〜12

34

0

Chiral separation
columns

40
35

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

30
25
20
15
10
5

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

40
35
30

25
20
15

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

固相吸着剤

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

0

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

医 薬 精 密 精 製 用 充 填 カ ラム

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

Bioseparation columns
and materials

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

degradation ratio

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index
MCI GEL™ material list

Compounds index

MCI GEL™ material list

MCI GEL™ material list

Compounds index

degradation ratio

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

10

Column selection
guideBioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10
10
10
10
10
10

25 min.
20

15
10
5
0
25 min.
20

QuinineCinchonine

9

15
10
5
0

10

10

0.2

11
fiowing time hr.

10
fiowing time hr.

200
150
100
50
0
200
150

9
9
0.4

100

50

9
0.6

0

0

0.4

ODS column

9

0.2

2
ODS column

9

0

9

9

9

9

9
10

9

3

8
Caffeine

Theobromine

H

N

8

8
8
8

0.8

O

8

8

Theophylline
0.8

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Bioseparation columns
and materials

7

H

8

8

N
N
O
N

N

H

N
H
1
N

N
O
N
CHP20/C04

1
CHP20/C04

0.6

9

Column selection
guideColumn selection
guideColumn selection
guide

Ion chromatography
columns and materials

Ion exchange columns
and materials

7

1

Column selection
guide

7

36
35

7

N

N

N
N
HN
H
N
1

8

7

O

OH
H
O

H
OH
H
H
O
O

7
N

7

7

7

7

The polymeric RP columns are chemically stable. Specifically, the columns have resistance to an alkaline eluent.
The following graphs demonstrate stability of the polymeric columns. After feeding a solution of pH 12 into the
MCI GEL™ CHP20/C04, there is no change of column performance.

2

6
6
6

1,2

1,2

Conditions
Column 6

6：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
Eluent：0.1M NaH2PO4 pH2.0
CH3CN=88/12
Flow rate：0.3
Column temp.：25℃
Detection：275nmSample：1.Cinchonine
2.Quinine
7

Conditions
Column ：MCI GEL™ CHP20/C04 4.6mmI.D × 150mm
Eluent：20mM Na2HPO4 pH12/CH3CN/=60/40
Flow rate ：0.4
Column temp.：25℃
Detection ：254nm
88Sample ：1000ppm Dimethyl phthalate 5μL

6
6：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
Eluent：H2O/CH3CN=10/90
Flow rate：0.4
Column temp.：25℃
Detection 7 ：275nm
Sample：1.Theophylline
2.Theobromine
3.Caffeine

6

Conditions
Column6

6

Hydrogen bond effect

6

5
5
5

6

5

5

5

5

5

N
H
HN
H2N-CH2

NH2

1

Fig. 5-5 Cinchona alkaloids

Fig. 5-4 Purine alkaloids

Durability of polymeric column

5
min.

6

H
N
COOH
H2N

C

N
H

5

Hydrogen bond effect

O Si

OH
Si

7
Fig. 5-1 Column durability at pH12 comparison between CHP20/C04 and an ODS column

5

4
4

5

4

3

4
Phthalic 4acid dipropyl ester

4

4

4

OH

4
C

O

4

Hydrophobic interaction Interaction mechanismmin.

PrOOC COOPr

2

4

5

π-π interaction(double bond effect)

Phthalic acid diethyl ester

4

H
N

3

COOH

4
O

O

3

NH2

Silica gel C4, C18

Polymethacrylic adsorbent

4

O

3

COOH

2

5

3
EtOOC COOEt

3
3

3 Serotonin

Phthalic acid dimethyl ester

35-hydroxy tryptophan

3

Hydrogen bond effect

Alkyl effect

NH2

N
H

2

Interaction mechanism

3

3

3

2

H
N

2

2

(CH2)n-CH3
Si
O
Si

H 2N

(CH2)2-CH3

H2N-CH2

2

O

2

O
C
O

C

1
Weak interaction

Stronge interaction

2

3

MeOOC COOMe

1：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
Eluent：50mM Na-phosphate pH2.0,
1.5% Hexanesulfonic acid /CH3CN＝80/20
Flow rate
：0.25
NH 2
OH H
HO
Column temp.
2：ambientN
HO
Detection：280nmHO 2
2
Sample：1. Epinephrine
HO
Dopamine
2. Dopamine
Epinephrine
3. 5-Hydroxy tryptophan
4. Serotonin
HO
COOH HO5. Tryptophan
NH 2
NH 2
N
N
1
H
H
3

Conditions
Column1

1

12：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
Eluent：H2O/CH3CN＝50/50
Flow rate：0.75
Column temp.：60℃
Detection：254nmSample：1. Dimethyl phthalate
2. Diethyl phthalate
22
3. Dipropyl phthalate

Conditions
Column1

Fig. 5-3 Separation of phthalic acid esters

1

Fig. 5-2 1 Separation of catecholamines

1
Polymethacrylic adsorbent

1
Silica gel C4, C18

1
Polystyrenic adsorbent

1

Hydrophobic interaction

O

1

Application data of CHP series
Retentiveness in reverse phase modeColumn selection
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ア ミ ノ酸 D L 分 離 用
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医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

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chromatography columns and materials
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chromatography columns and materials
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chromatography columns and materials
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生体高分子分離用
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10

10

10

分離例化合物リスト

10

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

38
37

10
10

11
10
10
10
10
10

min.
20
15
10
5
0

9

9

9

9

9
10

min.
30

25
20

15
10

5
0

8

9

H
H

9
9
9
9

8

：ODS column (5μm)
4.6mm I.D.×150mm
Eluent：50mM NaH2PO4 pH6.0/CH3CN＝40/60
rate
：0.3
9
9Flow
Column temp.：25℃：210nmDetection
Sample：1.Cholic acid
2.Ursodeoxycholic acid
3.Deoxycholic acid8

8
deoxycholicacid
8
Ursodesoxycholic
acid
8

H
HO
OH

H

8

cholic acid

H

COOH
OH
COOH
COOH

OH

HO

H

8

1

8

8
11-deoxycortisolhydrocortisone 8 corticosterone

8

O

H
H

7
7

9

H
H
H
HO

7

7

min.
20

OH
HO

Conditions
ColumnODS column

3

H
H
H

O
O

H

OH
OH
O
O

OH
HO
OH
OH

O

3

7

7
7

2

7

2

2

7
15

7

10

5

7

0

6
6
16

6
6
6
6

3

Conditions
Column

CHP20/C04

1

Fig. 5-7 Bile acids

5

5
5
5
5
5

：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm 6
Eluent：H2O/CH3CN：60/40Flow rate：0.5
Column temp.：45℃
Detection：280nmSample：1.Hydrocortisone
2.Corticosterone
3.11-Deoxycortisol

7Comparison with an ODS column

6

Conditions
ColumnFig.65-9 Adrenal cortex hormones

4

7

5

5

4

min.
20
15
10

：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
Eluent：50mM NaH2PO4 pH2.0/CH3CN＝40/60
6 Flow rate ：0.3
6
Column temp. ：25℃
Detection：210nmSample：1.Cholic acid
2.Ursodeoxycholic acid
3.Deoxycholic acid

6

5

5

5

5

4
4

5

4
min.

4 40
35
30
25 4
20

4 15
10
5

4

0

4
4
4

3
3

4

3

3

Glycyrrhizic acid3
Orotic acid

Uric acid 3

3Theophylline
Xanthine

3

5

HN

3

3
O
N
H
O
N
H

N
HO
N
N
O

N
N
H
O

2

Hypoxanthine
3

HN
O
HN
N
HN

H
N

2

3

OH
O
COOH
H
N

O
H
N
O

3

H
O O
HO
H
H
O
HO H O
H
H
H
O
O
HO
H
H
H
H
HO H
O
HO
Glycyrrhizic acid

0

4

5

N
H

2
2
2
2

1

N

2
2

2

HO
HO H
H

2

：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm：2.06% acetic acid/CH3CN
Eluent=63/37：0.5
Flow rate
Column temp. ：45℃
Detection：254nm2
2：Extract ofSampleglycyrrhizae radix

2

O

1
1
3

N

1
1

Conditions
Column1

Fig. 5-8 Glycyrrhizae radix

1

1
1：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm：10mM TBA/CH3CN=75/25
Eluent：0.4
Flow rate
Column temp.：25℃
Detection：284nmSample：1.Hypoxanthine
2.Xanthine
3.Theophylline
2
4.Uric acid
5.Orotic acid

Conditions
Column1
Fig. 5-6 1Uric acid and related
1 compounds

1

O

1

Application data of CHP series
Application data of CHP series

Column selection
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ア ミ ノ酸 D L 分 離 用
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Analytical and preparative
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医 薬 精 密 精 製 用 充 填 カ ラム

固相吸着剤

Analytical and preparative
chromatography columns and materials
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chromatography columns and materials
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chromatography columns and materials
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Analytical and preparative
chromatography columns and materials
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Chiral separation
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chromatography columns and materials
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分離例化合物リスト

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Compounds index

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10

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
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10

10

11
10
10
10
10

min.
30
25
20
15
10

40
39

10

10 min.

10

8
6
4

10

2
0
25 min.

20
15

10
5

0

10

Vitamin B12

9

9
4

9
9

5

NH2

9

N
HO

9

Procaine

9

H2N

2
3
1

9

0

O
O
HN

O

N
O

4

N
Co3+
N- N
H2N

9O

OH N
P
O-O OO

3
2

9
10

N
O
O

91

：ODS column
4.6mm I.D.×150mm
Eluent：20mM phosphate pH6.8/CH3CN＝90/10Flow rate：0.5
Column temp.：45℃
Detection 9 ：254nm
9Sample：1.Succinylsulfathiazole
2.Sulfanilamide
3.Sulfathiazole
4.Sulfamerazine
Conditions
Column

8
8

CN

NH2
H2N

O

8
NH2
O
O

8
O

8

8

8

H2N

8
Sulfamerazine

sulphathiazole

8
Sulfanilamide
Succinylsulphathiazole

8
8
8

2

Vitamin B3

N
H

N

H2 N

NH2
NH 2
NH 2
NH 2
O

Procainamide

N
S
S
O O
S

7Vitamin B6

7
7

1

HO

7

O

S
N O O

N
S
O O
S
O O

Vitamin C

7
7

N
H 2N

OH

O

7
N

7

H
N
H
N

N

OH
HO

min.
30
25
20
15

10

7

3

H
N

HO

：MCI GEL™ CMG20/C04
4.6mm I.D.×150mm
Eluent：8mM Na2HPO4 pH7.0/CH3CN＝85/15
Flow rate：0.5
Column temp.：25℃
Detection：254nmSample：1.Vitamin
7 C
2.Vitamin B6
3.Vitamin B3
4.Vitamin B127

65

Conditions
Column

2

5

5
5
5

Fig. 5-11 Sulfa drugs

H
N

H
OH

O

6
Conditions
ColumnConditions
Column

6
1

6

5

6
6 O OH OH
Fig. 5-15 Water-soluble vitamins

64

Comparison with an ODS column：MCI GEL™ CMG20/C04
4.6mm I.D.×150mm
Eluent：20mM phosphate pH7.2/CH3CN
7＝65/35
Flow rate：0.5
Column temp.：45℃
Detection：254nmSample：1.Procainamide
7
2.Procaine

0

6

4

：MCI GEL™ CMG20/C04
4.6mm I.D.×150mm
Eluent：20mM phosphate pH6.8/CH3CN＝82/18Flow rate：0.5
Column 6
temp.：45℃
6
Detection：254nmSample：1.Succinylsulfathiazole
2.Sulfanilamide
3.Sulfathiazole
4.Sulfamerazine

4

5

6
Fig. 5-14 Procainamide, Procaine

6

40 min.
30
20
10
0
10 min.
80Angiotensin ll

1

4

5

6
4
2

5

5

5

5

5

O

O

N

NH

O

N
H

3 4

N

4
4

6

10
5
0

H
O

4

5

min.
30
25

20

3

HN

4
HN

4

OH

3

HO

4

Phenacetin

AspirinCaffeine

OAc

3

2

4

N

4

1

4
4

O

COOH
N

O
HO

NHO
NH 2
O

O
NH

NH

NH
O
H 2N

N
H

15

3

N
N
O

Antipyrine

NHAc
O

Met Enkephalin

3

O

3

N

2

HO

3
Dimethylaminoantipyrine
Aminopyrine

4

N

N

3

5

3

3
Leu Enkephalin

3

OH
O

3

3

O

O

N
NH 2 H

3

N
H

H
N

2
2

O

2
2

O

S

2 NH

2
2

N

Gly-Tyr2

N2

Conditions
Column 1

Fig. 5-10 Ingredients of medicine

N
NH2 H

O

N
NH H

HO
O
O

O

Conditions
Column

HO O
H HN
N
O

Conditions
Column

1
1

1

1
1

3

H
N

：MCI GEL™ CMG20/C04
4.6mm I.D.×150mm
Eluent：A;0.05%TFA/CH3CN=80/20B;0.05%TFA/CH3CN=20/802
A→B 30min.linear
Flow rate：0.5
Column temp.：25℃
Detection：280nmSample：1.Ribonuclease A
2.Cytochrome c
3.α-Chymotrypsinogen A

2

1O
1：MCI GEL™ CMG20/C04
1
4.6mm I.D.×150mm
Eluent：50mM phosphoric acid(pH2.0)/CH3OH＝60/40Flow rate：0.5
Column temp.：45℃
Detection：254nmSample：1.4-Dimethylaminoantipyrine
2.Antipyrine
3.Caffeine22
4.Aspirin
5.Phenacetin

1

1 Peptides
Fig. 5-12

O：MCI GEL™ CMG20/C04
4.6mm I.D.×150mm
HO
Eluent：0.1%TFA/CH3CN=70/30Flow rate 2 ：0.5
Column temp.：25℃
2
Detection：220nmSample：1.Gly-Tyr
2.Met Enkephalin
HO
3.Leu Enkephalin
4.Angiotensin ll

1

1
Fig. 5-13 Proteins1

Application data of CHP series
Application data of CHP series

Column selection
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chromatography columns and materials
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chromatography columns and materials
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chromatography columns and materials
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chromatography columns and materials
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Chiral separation
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columns

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columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
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Bioseparation columns
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Analytical and preparative
chromatography columns and materials
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chromatography columns and materials
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Chiral separation
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医 薬 精 密 精 製 用 充 填 カ ラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
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イオンクロマトグラフィー用
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UV 238nm (AU)Column selection
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イオン交換クロマトグラフィー用
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Column selection
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Column selection
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固相吸着剤

SPE sorbent series

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7

7

MCI GEL™ column list

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MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

Compounds index

Compounds index

Compounds index

Compounds index

10

10

10

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

42
41

10
10
11
10

10
10
10

10

5

10

9

15 min.
10
15 min. 0

10Amphotericin B

99Amphotericin B

9

5
0

9

9

9
10

9
9

9
Filipin8

25 min.
20
8

15

8 10

5
0
25 min.
8

20
15
8

10
5
0

8
8
8

Conditions
Column ：150 ×4.6mm I.D.
Eluent： A :0.1% TFA;
B :0.1% TFA in AcCN
Flow rate ：1.00
9
9
Column temp.：20%B-60%B over 20min;
Detection ：UV280nm;
Sample ：Ribonuclease A and Conalbumin 2mg/ml;.
Injection ：10μl

9

ODS 10μm
CHP20/C10 10μm

7
OH

7

OH

7

7

OH
O

Filipin

7

OH
H 2N

O
HO

7
7

OH
OH OH OH OH OH OH

H
O

Nystatin

O
HO
O

O

7
OH

O

6
Ribonuclease
A Conalbumin
6

6
Ribonuclease A Conalbumin
6

6

ODS 10μm

6O
OH OH O

6
OH

6

O
OH
OH

H 2N

OH
OH

Amphotericin B

6
O

OH
OH OH
O
O
HO
OH OH OH
O
OH

Nystatin

8
8 Filipin
8

Nystatin

8

5
5
5

6

Conditions
6：MCI GEL™ CHP20/C10 (10μ6 m 250 ×4.6mm I.D.) and
ColumnODS (10μm 250 ×4.6mm I.D.)
Eluent：A :0.1% Formic acid;
B :0.1% Formic acid in AcCN; A/B=60/40;
Flow rate ：1.00
Column temp.：25℃
Detection ：UV305nm for Nystatin, VIS405nm for
Amphotericin B and UV340nm for Filipin;
Sample：Pravastatin sodium, Mevastatin and
7 Simvastatin, 1mg/ml each;.7
Injection
：10μl

7

20
15

10
5
0

HO
HO

6

4
4

Fig. 5-17 Polyene antibiotics

5
4

Mevastatin

CHP20/C10 10μm

5

5

5

5

5

5
25 min. 0

Mevastatin

Fig.55-19 Proteins
25 min.
20

15
10

5

Impurity

4

Simvastatin

Pravastatin sodium

Simvastatin
Pravastatin sodium

3

5

4
4
4

3

4

Impurity

3
3
3

5

4
min.

4
30
20

4
10
0

4

4

3
3
3

2
2

1

3

2
2

H
O

ODS 10μm

23(+)-Simvastatin, Simvastatin

O

O
O

O
O

OH
O
OH

5

3

CHP20/C10 10μm

3

1

3
3

1
O

H

(+)-Compactin;
2
Mevastatin

1
1

Conditions
ColumnO
ONa
ConditionsO
OH OH O
Column：MCI GEL™ CHP20/C10H(10μm 250 ×4.6mm I.D.) andODS (10μm 250 ×4.6mm I.D.)
EluentHO： A :0.1% Formic acid;
B :0.1% Formic acid in AcCN;
Pravastatin sodium
2
Gradient 2 ：45%B-95%B over 29min.2
Flow rate ：1.00
Column temp.：25℃
Detection ：UV238nm
Sample：Pravastatin sodium, Mevastatin and Simvastatin, 1mg/ml each;.
Injection
：5μl

2

1

4

1

2

1

Fig.15-18 Proteins1
Fig. 5-16
1
1 Pravastatin sodium

1

2：MCI GEL™ CMG20/C10
4.6mm I.D.×250mm
Eluent：A 0.05% TFA/CH3CN＝80/20
B 0.05% TFA/CH3CN＝30/70
A → B 45min linear gradient
Flow rate：0.5
2 temp.：25℃
Column2
Detection：280nmSample：1. Ribonuclease A
2. Cytochrome C
3. Transferrin
4. α-Chymotrypshinogen A
5. β-Lactoglobulin

1

Application data of CHP series
Application data of CHP seriesAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

固相吸着剤

MCI GEL™ column list

SPE sorbent series

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

40

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

UV210nm(AU)Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

UV230nm(AU)UV230nm(AU)Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

UV230nm(AU)Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

UV210nm(AU)Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

UV230nm(AU)Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

UV230nm(AU)Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Ion chromatography
columns and materials

Ion chromatography
columns and materials

UV230nm(AU)Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

UV230nm(AU)Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

UV230nm(AU)Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

カラム選択の手引き

Column selection
guide

Ion chromatography
columns and materials

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

min.

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

10
10
10
10
10

Target

35
30
25
20
15

10
5
40

0

min.

35
30
25
20
15
10

Impurity

44
43

20

5

0

9

9

9

9

9

9

11
10
10
10
10
10
10

min.
18
16

14
12
10
8
6
4
2
20 0

min.

18
16
14
12
10
8
6
4
2

8

9

8

8
8
8
8

Ghrelin rat

9
9
9
9

CMG20/C10 10μm

Ghrelin human

Ghrelin rat
Ghrelin human

10

0CMG20/C10 10μm

Impurity9

ODS 10μm

7Target

7
7

9

8

8

8

8

7

7
7

8

6

ODS 10μm

7Conditions
Column： MCI GEL™ CMG20/C10
ODS 10μm
4.6mm I.D.×150mm
Eluent： 0.1%TFA,/CH3CN=68/32
Flow rate ： 1.0
Column temp.： 40℃ 7
7Detection ： 210nm
Sample： Sifuvirtide crude(purity 35.5%) 2.1mg/ml
Injection ： 0.4ml

7

6
6

6
6

10
6

4
2
0

14 min.
12
10

8
6

6

7

8

5
5

6
6

15
10
5

5

Fig. 5-21 Ghrelin

6

4

Fig. 5-23 Sifuvirtide

12

min.

5

5
min. 5

4

6

8

20
15
10
5
0
20

4

Conditions
Column： MCI GEL™
6 CMG20/C10
6
ODS 10μm
4.6mm I.D.×150mm
Eluent： A) 0.1%TFA, H2O
B) 0.1%TFA, AcCN
Gradient： 10%B→60%B over 25min.
Flow rate ： 1.0
Column temp. ： 40℃
Detection ： 230nm
Sample： Ghrelin rat and Ghrelin human ,0.1mmol/l each77Injection： 10μl14 min.

Buserelin

4

Insulin human recombinantInsulin glargine

6

5

5

Leuprorelin

4

3

4

LH-RH human

4

3

2

4

5

5

4
4

CMG20/C10 10μm

Insulin human recombinantInsulin glargine

3 10μmCMG20/C10

ODS 10μm

30Buserelin

54

LH-RH salmon

LH-RH salmon

4

0

10

3

3

4

5

Leuprorelin

5

LH-RH human

12
20

3

min.

15
10
5
0

4

3

14 min.

8
6

4
2
0

3

3

2

ODS 10μm

3Buserelin

2

Insulin human recombinantInsulin glargine

1

3

2
2

Leuprorelin

3

1

2

2

LH-RH human22

1
CHP20/C10 10μm

1Fig. 5-20
1 Insulin

1

Conditions
Column：MCI GEL™ CHP20/C10
MCI GEL™ CMG20/C10
ODS 10μm
4.6mm I.D.×150mm
Eluent：A) 0.1%TFA, H2O
B) 0.1%TFA, CH3OH
Gradient 2 ：20%B→60%B over 20min. 2
Flow rate ：1.0
Column temp.：40℃
Detection ：280nm
Sample：Insulin Glargine and human recombinant , 1mg/ml each
Injection ：10μl

2

1
1

1
1

Fig. 5-22 Leuprorelin

LH-RH salmon
Conditions
Column ： MCI GEL™ CHP20/C10
MCI GEL™ CMG20/C10
ODS 10μm
4.6mm I.D.×150mm
Eluent： A) 0.1%TFA, H2O
2 B) 0.1%TFA, AcCN
Gradient ： 20%B→60%B over 20min. 2
Flow rate ： 1.0
Column temp.： 40℃
Detection ： 280nm
Sample ： Leuprorelin,LHRH human, LHRH salmon and Buserelin ,1mg/ml each
Injection ： 10μl

1
1
CHP20/C10
10μm

1Application data of CHP series
Application data of CHP series

MCI GEL™ column list
MCI GEL™ material list

MCI GEL™ material list：：

UV210nm(AU)SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

：
：
：
：
：

Ade

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Gua

Chiral separation
columns

SPE sorbent series

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Cyd
Ado
Cyt

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

Guo

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

UV210nm(AU)UV210nm(AU)UV260nm(AU)Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column listdT

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

7

SPE sorbent series

Hyp

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

7

SPE sorbent series

Xao

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

固相吸着剤

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

医 薬 精 密 精 製 用 充 填 カ ラム

Bioseparation columns
and materials

及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Xan

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index
MCI GEL™ material list

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Ino
Thy

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Urd

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ura

Column selection
guide

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

intensity / -Column selection
guide

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guide

Ion exchange columns
and materials

Column selection
guideColumn selection
guide

10

46
45

10
10

10

10

10

(Data provided by Professor Yokoyama of Yokohama National University)

11
10
10
10

10
分
8
6
4
2

10

10

14
12

9

0

tR / mim

10
8
6
4
2

9

9

9
9
9
9
9

0

9

9

9

Linalool

9

10

8

8

8

8

8

6
CMG20/C10 10μm

7
7
7

7

8

9

5

8

6

4

8

6

4

Fig. 5-25 Nucleotide

8

6

4

5

8
8
8

6
6

4

5

Conditions
Column：MCI GEL™ CMG20/C10
4.6mm I.D.×150mm
Eluent：Hexan/Ethanol=99.5/0.5
7 rate ：1.0
Flow
Column temp. ：40℃
Detection ：210nm
Sample：Coriander
Injection
：10μl
7

7

4

Fig. 5-27 Coriander

6
6

5

5
5

4

6
Conditions
Column ：MCI GEL™ CHK40/C04
64.6mm I.D.×150mm
66
6Eluent：A)19 mM H3PO4 / 1 mM NaH2PO4 / 5.0% ACNB)20 mM Na2HPO4 / 100 mM NaClO4 / 30% ACN
Gradient ：0-4.0min 0%B
4.0-5.0min 0→30%B 5.0min-6.0min 30%B 6.0min-7.0min 30→50%B
7.0min-10.0min 50→65%B
10.0min-11.0min 65%B 11.0min0%B
Flow rate ：0.8
Column temp.：50℃
Detection ：UV260nm
Sample：1.Ura，2.Xan，3.Thy，4.Hyp，5.Gua，6.Cyt，7.Ade, 8.Urd，9.Xao，10.dT，11.Ino，12.Guo，13.Cyd，14.Ado
Injection ：20μl
7
7
7
7

5

5

5

5

Injection

5

5

15

Conditions
Column

4

5
min.

10
5

20

4
4
4
4

min.

15
10
5
20

0

min.

0

EluentFlow rate
Column temp.
Detection
SampleMCI GEL™ CMG20/C10
ODS 10μm
4.6mm I.D.×150mm
4Hexan/Ethanol=99.5/0.5
1.0
40℃
210nm
1:Linalyl Acrtate 1mg/
2:Linalool 1mg/
3:β-Citronellool 1mg/
4:Nerol 0.5mg/
5:Geraniol 0.5mg/
10μl
0

3

4

3
3
3

ODS 10μm 40℃

3

3

15
10
5

3
3

3

3

3
3

2
2
2
2

3
3

CMG20/C10 10μm

Conditions
Column ：MCI GEL™ CMG20/C10
ODS 10μm
4.6mm I.D.×150mm：A)100mM TEAA, H2O
EluentB)100mM TEAA, CH3CN
Gradient ：CHP10/C10 10%B→40%B over 30min
2 30min
2 ODS 10μm 8%B→40%B over
Flow rate ：1.0
Column temp.：40℃
Detection ：260nm
Sample：14-30 ssRNA Ladder Marker [max.0.04mg/
Injection ：5μl

]

1

2

30 base

14 base22 base
26 base3
CHP20/C10 40℃

1
18 base1

CHP20/C10 60℃

1

5

2

2

1

1
1
1

Fig. 5-24 ssRNA Ladder Marker

1

2

2
4

2
2

ODS 10μm

2

1
4 5
2

1
1

1

1

Fig. 5-26 Linalool

1

Application data of CHP series
Application data of CHP seriesCompounds index

Compounds index

Gua

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Guo

dA

Ade
Gua
Guo
Cyd

MCI GEL™ column list

MCI GEL™ material list

dT
Xan

Ade
dA

Cyd
dT
Xan

Gua
Guo

Guo
Cvd
Cvt
dC
Gua
Ado

dA

Ade

SPE sorbent series

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material listdT
Xan

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

Urd

Xao
dT

Xan
Hyp

UMP
GDPAMP
Urd
Ino UraIntensity /-Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

Ura
Ino

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL
カラム一覧

Urd
Ura
Ino

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

Urd
Ura
Ino

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Bioseparation columns
and materials

IRB

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

VAL

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

LOS

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

CAN

Column selection
guideColumn selection
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guide

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SPE sorbent series

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10

及び充填剤

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columns

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columns

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columns

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10

MCI GEL™ column list

Analytical and preparative
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for pharmaceutical applications

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and materials

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columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
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columns

SPE sorbent series10

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columns

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for pharmaceutical applications

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イオンクロマトグラフィー用
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and materials

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columns and materials

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and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications10

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guide

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10

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9

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109

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10(Data provided by Professor Yokoyama of Yokohama National University)

9

min.

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guideColumn selection
guide

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Column selection
guideColumn selection
guide

10

3

10
10
11

12

11
10
9
8

7
6
5
4
2
1
0

9

min.

3

A new category of beer that contains 85% less purine

9

9

912
11
10
9

98
7
6

94

5

Carbohydrate-free "happoshu-type" beer

2
1
0

12

11
10
9
8

7
6
5
4
3
2
1

8

8

8

Draft Beer

8

8

8
8

10
9
9
9

Analysis of various category beer

：MCI GEL™ CHP07/C04
4.6mm I.D.×150mm
7Eluent 7：CH3OH/10mM-Acetic acid＝60/40：0.46
Flow rate
Column temp.：60℃
Detection：280nmSample：Polyphenon 60(10mg/ ) each 10μL

9 0

12
10
8
6
：MCI GEL™ CHP20/C04
4.6mm I.D.×150mm
7 3OH/10mM-Acetic acid＝60/40
7
Eluent：CH：0.46
Flow rate
Column temp.：60℃
Detection：280nmSample：Polyphenon 60(10mg/ ) each 10μL
Conditions
Column

8
8
8

7

min

4
2
0

7
7

7

Fig. 5-30 Styrene Divinylbenzene CHP20/C04

Fig. 5-29 Modified Styrene Divinylbenzene
CHP07/C04(Data provided by Professor Yokoyama of Yokohama National University)

48
47

6

4

7

6

6
6

Fig. 5-33

6
6
6(Polyphenon 60)

6

min.

6
5

2
0

5

5
5
5

4

7

6

：MCI GEL™ CHK45/C05
4.6mm I.D.×150mm
Eluent：A）8 mM H3PO4
6B）10 mM H3PO4 /30% ACN
0-0.7min
0%B
0.7-3.0min
0→40%B
3.0-3.2min 40%B
Gradient
3.2-3.5min 40→80%B 3.5-8.0min 80%Β 8.0min- 0%B
Flow rate：1.3
Column temp.
7 ：45℃
Detection：UV260nm
Injection
：20μl

6

8
8

4
4

7

6

5

5

4

Conditions
Column4
4
4

5Conditions
Column7

6

Application data of Nucleic base/Nucleoside and Beer

5

min.

5

5

5

4
4

5

3
3
3
3

min.

4
4

n=9.6

4

3
3
3
3

N

O

n=9.6

3
3

Losartan

N
Cl
N

3

O

HO

Candesartan

N NH
N N
HO

Irbesartan

N
N N
HN
N

N

O
HO

O
N

1
：MCI GEL™ CHK40/C04
Column4.6mm I.D.×150mm
Eluent：A）10 mM NaH2PO4 +0.2 mM Na2HPO4 (25%ACN)B）10 mM NaH2PO4 +1.0 mM Na2HPO4 (40%ACN)
Gradient ：0.5min 0%B 0.5-2.0min 50%B
2.0min- 90%ΒFlow rate ：1.0
2
Column temp.：50℃
2
Detection ：UV
Sample：Candesartan(CAN),Losartan(LOS),
Valsartan(VAL), Irbesartan(IRB)
Injection ：20μl

2

3

2

N
N
N NH

1

4

2
2
2

Valsartan

3

2：MCI GEL™ ODS-1HU
4.6mm I.D.×250mm
Eluent：50vol%CH3CN
Flow rate：1.00
Column temp.：40℃
2
Detection2 ：254nm
Sample：Triton X-100(Polyoxyethylene octyl phenyl ether)
1% each 10μL

Conditions
Column：MCI GEL™ CHPOD/C04
4.6mm I.D.×150mm
Eluent：50vol%CH3CN
Flow rate：0.50
2 temp.：40℃
Column2
Detection：254nmSample：Triton X-100(Polyoxyethylene octyl phenyl ether)
1% each 10μL

O

N NH
N N
N

1
1
Conditions
1

2

1
Fig. 5-31 C18-alkylated aliphatics
CHPOD/C04 1

1(TritonX-100)
1
1Fig. 5-28 Application data of CHK40/C04：Sepatation of Sartans

Conditions
Column1
1Fig. 5-32 ODS-1HU
(ODS)

1

Application data of CHP series
Application data of CHP seriesBioseparation columns
and materials

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MCI GEL充 填 剤一覧

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カラム一覧

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MeOH (%)

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Compounds index

UV 280nm (AU)Column selection
guide

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and materials

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and materials

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and materials

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and materials

医 薬 精 密 精 製 用 充 填 カ ラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

Bioseparation columns
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chromatography columns and materials
for pharmaceutical applications

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MCI GEL™ material list

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Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index10

イオンクロマトグラフィー用
充填カラム及び充填剤

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and materials

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columns and materials

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and materials

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chromatography columns and materials
for pharmaceutical applications

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columns

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columns

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columns10

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Analytical and preparative
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10

Column selection
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guide

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10

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10

10
BV

10

10
10

11

20

10

0
7
min.
6
5

4
3
2
1
0

-0.1

9

9

9

9
9
9

0

40
0.3

80
0.7

9

9

9

10
0.1

10

0.4

8

9

0.8

60

8

9
0.2

8

8

8
8
8
8
8
8

0.5
9

100

150
CMG20/P150

7 CMG20/C04

0.6

7
7
7

7
25
CMG20/P30

7None

CHP07/P120

30

7

10
CMG20/P10

7
Po lyme tha crylate

25

CHP07/C10
120

CHP07/C04

25

6
10

6
CSP50/P10

6
6
6

CMG20/C10

66

6
6 CHP20/C10

7

6

Fig. 5-36 Extract of green tea leaves

drug compounds
PeptidesProteins
25
30
CHP50/P30

20
CHP50/P20
S tyren e Divinylbe nz ene

5CHP20/C10

5
70

0.9

6

Conditions
Column ：MCI GEL™ CHP50/P20, 32mmI.D×465mm
Eluent ：0−185min, CH36
OH:0.01M Acetic acid(35:65) 6
185−350min, CH3OH:0.01M Acetic acid(50:50)
Flow rate ：7.48
Detection ：280nm
Sample ：extract of green tea leaves, injection volumn 18.7
1. Epigallocatechin
2. Catechin
3. Epicatechin
4. Epigallocatechin gallate
5. Gallocatechin
77
6. Epicatechin gallate
7. Caffeine

5

5
120

5
CHP20/C04

50
CHP20/P50

5
CHP20/P70

5

Br

5

5

5

5

Phthalic acid dipropyl ester

5

CHP20/P120

Penicllin V

COOPr
PrOOC

30
CHP20/P30

0 5 10 15 20 25 30 min.

CHP20/P120(120μm)
CHP20/P70(70μm)

CHP20/P50(50μm)
CHP50/P30(30μm)
CHP50/P20(20μm)

20
CHP20/P20

Column selection
guideColumn selection
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444

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and materials

4

Equivalent
HPLC column

Mainapplication
Pore
diameter[nm] 4

Particlesize[μm]
Product name
Functionalgroup

カラム選択の手引き

Column selection
guideColumn selection
guide

3

4

None

COONa

N

3

2

4
CH3
O

4CONH

4

O

3

4
4
S

CH3

2
3
3
2

4
Phthalic acid diethyl ester

Penicllin G

3

2
2

2
COOEt

3

3
COONa

3
1

3
1

3
6-Aminopenicillanic acid

3

EtOOC

H H

CH3
O

N

CH3
H H

S
CONH

Phthalic acid dimethyl ester

1

COONa

N

O

COOMe

3
3

MCI GEL™ CHP50 series and CHP20 series are both ST/DVB polymers, but they differences in porosity.
Pore size of CHP20 series is fairly larger than that of CHP50 series. Appropriate packing material can beselected in accordance with molecular size of injection samples.

50
49

2

8

9

2

7

8

2

3

1

3

Base p olymer

-

7

2

1

3

●CHP material series

45

5

2

MCI GEL™ CHP material series are chromatography materials of porous type polymers.

CH3

3

4

1

MeOOC

3

1

CH3

2
2
2

Because polymeric materials are chemically stable, wide pH range, from acidic to alkaline eluents are able
to be applied to MCI GEL™ CHP material series.

2

1

S

1
Conditions
Column：MCI GEL™ CHP series, 10mml I.D.×250mmL
Eluent：CH3OH/0.05M Phosphate buffer (pH8.0)=60/40
Flow rate ：2.18
Column temp.：25℃
Detection ：254nm,
Sample：1.6-Aminopenicillanic acid 1000ppm
2.Penicillin G
1000ppm22
3.Penicillin
V
1000ppm
Injection ：100μl

1Conditions
Column：MCI GEL™ CHP50/P20, 10mml I.D.×250mmL
Eluent：H2O/CH3CN=20/80
Flow rate ：0.75
Column temp.：25℃
Detection ：254nm,
Sample：1.Dimethyl phthalate 0.5%
2 2.Dipropyl phthalate 0.5%
1
3.Dibutyl phthalate 0.5% 2：100μlInjection

1

H H

1

Fig. 5-35 Penicilin antibiotics

1

1

Fig. 5-341 Phthalic acid esters

1

1

and preparative chromatography columns and
CHP material series Analyticalmaterials for pharmaceutical applications

H2N

1

Application data of CHP 50
5Column selection
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Analytical and preparative
chromatography columns and materials
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Analytical and preparative
chromatography columns and materials
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Analytical and preparative
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Analytical and preparative
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chromatography columns and materials
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Analytical and preparative
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Analytical and preparative
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Analytical and preparative
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固相吸着剤

6

ア ミ ノ酸 D L 分 離 用
充填カラム

6

Chiral separation
columns及び充填剤

医 薬 精 密 精 製 用 充 填 カ ラム

Bioseparation columns
and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

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and materials

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columns and materials

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columns and materials

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Column selection
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Compounds index

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10

10

10

MCI GEL™ material list

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MCI GEL充 填 剤一覧

Compounds index

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Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index
MCI GEL™ material list

Compounds index
MCI GEL™ material list

10

Column selection
guideColumn selection
guideColumn selection
guide

10
10
11
10
10
10
10

10

300 min
240

180
120
60

52
51

9
9

0

9

9

9
10

9
9
9
9

Sennoside A
Purity: 90.3%,
Recovery: 60.9%

480
400
320
240
min
160
80
0

Dihydrocapsaicin Capsicin

Dihydrocapsaicin Capsicin

30
25
20
15
min
10

8

8

8

8

8
8
8
8
8

Conditions
Column：MCI GEL™ CMG20/C10, 4.6mmI.D.×250mm
MCI GEL™ CMG20/P150, 20mmI.D.×500mm
Eluent：Hexane/EtOH=87.5/12.5;
9 for CMG20/C10, 2.36ml/min9for CMG20/P150;
Flow rate ：1.00
Column temp.：25℃
Detection ：UV 280nm：Capsici Fructus extract;
SampleInjection ：20ml for CMG20/C10, 1.5ml for CMG20/P150.

9

7
7

5

7
7

0

7
7

9

8

7
7

6

Fig. 5-38 Elution profile of senna pulv. extract separated on MCI GEL™ CHP20/P30

7

8

5

5
5

7

8

4

CMG20/P150 (150μm)

74CMG20/C10 (10μm)

7

6
6

4

7

6
6
6

Conditions
6 ：MCI GEL™ CHP20/P306
Column32mm I.D.×490mm
Eluent：CH3OH + 1% Acetic acid= 60 + 40 (vol.)Flow rate ：7.88
Detection ：270 nm
Sample：Extract of senna pulv., partially purified by Diaion HP20
Injected amount：39.4

66

6 5-40 Capsicin
Fig.

5

180 min

5

120 5

5

60

5

0

5

4

5

Sennoside A

4
4

5

Sennoside B

4455 60 min
45 50
35 40
25 30
15 20
10

Sennoside B

5

4
4
4

5

Sennoside B

45 50
35 40

25 30
15 20
10
5

3
3
3

Sennoside B

055 60 min

45 50
35 40
25 30
15 20
10
5
0
55 60 min

3
3
3

5

2

3

（C）CHP20/P30 (30μm)

3

0

2

3

Sennoside A

Sennoside A

2

Chromatogram B
Chromatogram A

4
43

Conditions
Column：MCI GEL™ CHP20/P30
332mm I.D.×490mm 3：CH3OH + H2OEluent= 65 + 35 (vol.)Flow rate ：7.88
Detection ：420 nm
Sample：Extract of gardenia fructus
Injected amount：39.4
Sennoside A

2

Column（B）CHP20/P20 (20μm)

1
1

3

2
2
（A）CHP20/C10 (10μm)

1

1

2
2

2

Chromatogram C

2：MCI GEL™ CHP20/P30
10.0mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.)：2.4：270 nm：Extract of senna pulv. 80μL

2

1

1
1
Conditions：MCI GEL™ CHP20/P20
10.0mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.)：2.4：270nm：Extract of senna pulv. 80μL

2

1

1

1 5-39 Elution profile of gardenia fructus extract separated on MCI GEL™ CHP20/P30
Fig.
1

Fig.5-37 Senna pulv. extract

1：MCI GEL™ CHP20/C10
4.6mm I.D.×250mm：CH3OH/1% Acetic acid = 60/40 (vol.)EluentFlow rate ：0.5
Detection ：270nm
Sample ：Extract of senna pulv. 10μL

2

1

Application data of CHP series
Application data of CHP 20

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

1

guide

selection
カラColumn
ム選択の手引き

Column selection
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guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography

イオンクロマトグラフィー用
columns and materials
充填カラム及び充填剤

Ion exchange columns
and materials

Ion exchange columns

イオン交換クロマトグラフィー用and materials
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
Chiral separation
columns

Analytical and preparative
Bioseparation columns
Chiral separation
columns and materials
生体高分子分離用
医薬精密精chromatography
製 用 充 填 カ ラム
ア ミ ノ酸 D L 分 離 用
and materials
columnsfor pharmaceutical applications
充填カラム及び充填剤
及び充填剤
充填カラム

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

固相吸着剤

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

MCI GEL™ material list

MCI GELMCI GEL™ column list
カラム一覧

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GELMCI GEL™ material list
充 填 剤一覧

Compounds index

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds
index
分離例化合物
リスト

Compounds index

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

10

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

10

2

Ion exchange columns
and materials

10
10

10

1

Column selection
guide

10
11
10
10

2.1
1.9
1.1
0.9

10
10

2

1.7
1.5
BV
1.3

8
6

min.

40

30
20
10

10

4

8

1

Tocopherol
group

9

54
53

9

9
9
7
5

9
Tocotrienol
group 9

(6)

CMG20/C10

3

9 1

(2)

8
2 6

7 9

45

3

4

7

5

8

●Separation
mechanism8
8

8
8
8
8
Silica gel

8
8
8

1

7
0

10

●USP L32 column

87
7

base material

1. The CRS series columns separate over 20
D,L-α-Amino acids by only single column. The
columns separate not only α-Amino acids but
also α-Hydroxy carboxylic acids and derivative
amino acids such as Acetylated amino acids.
99 resolution
2. The columns
provide excellent
operated at room temperature.
3. The columns show high durability.

MCI GEL™ CRS10W and its companion product MCI GEL™ CRS15W (an optical
9 are based on a 3μm with 10nm mean pore diameter of silica gel
isomer of CRS10W)
coated with N,N-Dioctyl -L(or D)-alanine which is a novel optical activated ligand. The
chiral resolution mechanism is a combination of ligand exchange and hydrophobic
interaction. A copper sulfate aqueous solution is used as an eluent. Elution samples are
directly detected at wave length of 254 nm because complex compound, composed of999sample molecule10
and copper in the eluent, are object of detection. With the CRS10W,
D-isomers generally elute in front of L-isomers while L-isomers elute ahead of
D-isomers on the CRS15W. The hydrophobic interaction mechanism allows
hydrophilic samples to elute faster than hydrophobic molecules. Long alkyl chain
or aromatic compounds will elute late or require an organic solvent (CH3CN
or CH3OH, max. of 15v/v%) to prevent adsorption onto the stationary phase.

●Separation
performance8
840 min.
20

7
7
7

7

6
6

7

non-polar surface

7
Fig. 5-44 Elution profile of tocopherol andtocotrienol in preparative scale

6

allo-L6
allo-D

6

6

opticalactivated ligand

min.

6

6
6
6
6

4

hydrophobic
interaction

Fig. 5-43 Mixture of tocopherol and tocotrienol: Comparison with silica gel column

Conditions
Column ：MCI GEL™ CMG20/P30
20mm I.D.×500mm：Hexane/C2H5OH = 98/2 (vol.)EluentFlow rate ：4.7
Detection ：295 nm
3 Oil, 50
Sample ：Rice Bran
Injection ：1260μL

180 200
100 120 140 160
80
60

40
20

5

5
5

36
min.
30
24

5

18
12
6

Conditions
Column：MCI GEL™ CMG20/P150, 41.2mmI.D.×550mm, ×4：Hexane/EtOH = 90/10
EluentFlow rate ：49.0 7 (SV=1.0)
7
Column temp.：25℃
Detection ：UV 292nm
Sample：Mixture of tocopherol and tocotrienol
Injection ：150 mL ( 50g/L )Conditions
Column：1. Silica gel 5SIL, 4.6mmI.D.×250mm
2. MCI GEL™ CMG20/C04, 4.6mmI.D.×150mm
7：1. Hexane/EtOH = 99/1
7
Eluent
2. Hexane/EtOH = 98/2
Flow rate ：1.0
Column temp.：25℃
Detection ：UV 292nm
Sample：Mixture of tocopherol and tocotrienol
Injection ：10μl( 1mg/mL )

7

4

5

0

6

O

H

5

H

4
4

0

5

4
4

7

3

3
3
3

R

4
4

4

5

6

Separation mechanism

L5
sample molecule5

ligandexchange

6552mM CuSO4/H2O
0.5

5

O
N

4

4

4

D

R
N

O
O

Cu2＋

5

4
Application of CRS10W
Fig. 6-1 DL-Isoleucine

44Separation
mechanism and performance of MCI GEL™ CRS series

4

33

3
4.6×50mm

L32
3

3

CRS15W 4.6×50
CRS10W 4.6×50

L32

3

USP
Particle size (μm)

Column dimensions

3
MCI GEL™ CRS10W

MCI GEL™ column

4.6×50mm

MCI GEL™ CRS15W

3

2
Fig. 5-42 Elution profile of Rice Bran Oilin preparative scaleFig. 5-41 Vitamin E in Rice Bran Oil

1

7

3
1

2
2

CH3
O
R3
R2

3

2
2

2
2
2
Conditions
Column ：MCI GEL™ CMG20/C10
4.6mm I.D.×150mm
Eluent：Hexane-EtOH = 98/2 (vol.)Flow rate ：0.5
Detection ：295nm
33Sample ：Rice Bran Oil, 50
Injection ：10μL

3

2○Chiral separation columns MCI GEL™ CRS10W（DLAA）
MCI GEL™ CRS15W（LDAA）

CH3
O
R3
R2

CH3
CH3
CH3
CH3
HO

2

1
CH3
CH3
CH3
CH3
HO

1
R1

2

1

1
1

1
R11 R2 R3CH3 CH3 CH3CH3 H CH3
H CH3 CH3H CH3
H
5. α-tocotrienol
6. β-tocotrienol
7. γ-tocotrienol
8. δ-tocotrienol
R1

1
Tocotrienol

11. α-tocopherol
2. β-tocopherol
3. γ-tocopherol
4. δ-tocopherol

R1 R2 R3CH3 CH3 CH3CH3 H CH3
H CH3 CH3
H CH3
H

1
Tocopherol

1

2

2

1

6 Chiral separation columns
Application data of CHP series

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index
MCI GEL™ material list

Compounds index

MCI GEL™ material list

60

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

固相吸着剤

SPE sorbent series

Chiral separation
columns

Chiral separation
columns

MCI GEL™ column list

40
50

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

SPE sorbent series

Chiral separation
columns

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

30

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Ion chromatography
columns and materials

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

SPE sorbent series

SPE sorbent series

Chiral separation
columns

Chiral separation
columns20

Ion exchange columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Bioseparation columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

20

Column selection
guide

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

カラム選択の手引き

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

MCI GEL™ material list

10
10
10
11
min.
20
20 min. 0010
20 min.
0Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

9

56
55

10

9

10

10

9

10
10

9

min.

9

9

9
35

9
30
25
20

9
15
10

9

5
0

9

9
D-Val

9
L-Pro
L-Val
L
L
D

60 min.

10
0

20 min.

0

10

8
8

10

3

8

8

8
L

8

0.5mM CuSO4,
8
1.0
Column temp.
：ambient
Detection：254nm

D-Pro

8
8
2mM CuSO4/CH3OH＝85/15(vol)1DD
2mM CuSO4,
0.5

2mM CuSO4/CH3OH＝85/15(vol)1

0
20 min.
7
0

8

L

70

8

D

720 min.

7

Fig. 6-12 Durability test

Fig. 6-10 Separation of
DL-tryptophan

8

6

min.

Fig. 6-11 Separation of
DL-lactic acid

Fig. 6-9 Separation ofDL-phenylalanine

7

6

20

The sample was continuously injected
800 times for approximately 500 hrs.
Changes of retention times andseparation ability are not observed.

7
7

1

7

20 min. 7

6
2

6

Conditions
Column：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent：2mM CuSO4
Flow rate ：0.5
Column temp.：25℃
Detection ：254nm
Sample：1. D,D-2,6-Diaminopimelic acid7
7
2. meso-2,6-Diaminopimelicacid
3. L,L-2,6-Diaminopimelic acid
Conditions
Column ：MCI GEL™ CRS10W 4.6mm I.D.×50mm：0.4mMCuSO4
EluentFlow rate ：1.0
Temp.
：ambient
Detection ：UV 254nm
Sample ：D/L Aspartic acid6

6Fig. 6-16 Separation of diaminopimelic acid

6
6

6

L
D
L
D
D

0.1mM CuSO4,
0.2
0.1mM CuSO
5 4,
0.5

5
2mM CuSO4,
1.0
0.5

5
5 2mM CuSO4,

Fig. 6-15 D/L-Aspartic acid

5

5

5

5

5

5

5

4

1

5

3

Fig. 6-8 Separation of
DL-lysine

min.

6

0

4
Fig. 6-7 Separation ofDL-histidine

min.

6

7

4
Fig. 6-6 Separation of
DL-glutamic acid

7

4

5

L

6

4
Fig. 6-5 Separation of
DL-aspartic acid6

4
4
20 min.
0

4
40 min.
20

4

0

D L

4

Phe
Eth

60 min.

4

3
3
3

Leu

4

40
20

0

4

3
3

4

3

Met

2

3
3

3

2
2

Nleu

L
D

2

3
3 Tyr

2
2
Val

Pro

NVal

3

2

2

1

3

2
2

2

Fig. 6-4 Separationof DL-Ser.

Fig. 6-3 Separation of aminoacids mixture

0.1mM CuSO24,
0.5
D isomers elute ahead of L isomers.

1
Conditions
Column：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent：2mM CuSO4/CH3OH＝85/15
Flow rate：1.0
Column temp.：25℃
Detection：254nmSample：1. D-α-Phenylglycine
2. L-α-Phenylglycine

2

D isomers elute ahead of L isomers.

1

Conditions
Column：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent：2mM CuSO4/CH3CN＝90/10
Flow rate：1.0
Column temp.：25℃
Detection：254nmSample：1. D-Met
2. L-Met
2
3. Acetyl-D-Met 2
4. Acetyl-L-Met

1

Fig. 6-14 Separation of methionineand
1 acetylmethionine 1

1

Fig. 6-13 Separation of DL-α-Phenylglycine

1
1

For all chromatograms, column temperature is room temperature and wave length is 254nm.
1 except for Fig. 6-9 1
1 CuSO4 aqueous solution
1and Fig. 6-10.
All eluents are

1

Fig. 6-2 Separation of aminoacids mixture

Application data of CRS10W
Application data of CRS10W

Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

10

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

0Chiral separation
columns

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

固相吸着剤

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

10

10

STOP

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

START
10
START

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

50
40

STOP
Chiral separation
columns

Chiral separation
columns

分離例化合物リスト

Compounds index

0

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns30

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns20

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

ア ミ ノ酸 D L 分 離 用
充填カラム

Chiral separation
columns

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns10

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Ion chromatography
columns and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

0

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Chiral separation
columns

40

Column selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

30

Column selection
guideColumn selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

20

Column selection
guide

1

Column selection
guide

Ion exchange columns
and materials

Ion chromatography
columns and materials

10

Column selection
guide

1

Column selection
guide

Ion exchange columns
and materials

60

Column selection
guide

1

Column selection
guide

10
10

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

58
57

10
10
10
11
10
10
10
10
10

min.

7.5
5.0
2.5
0.0

7.5
5.0
2.5
0.0

10

9

min.

9

9
9
9
9

8

8

9

9

9

9
9

10

←L
L

9

9

7
7

8

8

7
7
7

2mM
8 CuSO4
0.5
L

6
Fig. 6-20 DL-P-Hydroxyphenylglycine

8

8
8
8
8
8
8

7

D

CRS10W

D

CRS15W

Conditions
Column ：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent ：2mMCuSO4:MeOH＝85:15
Flow rate：1.0
Temp. ：30℃
Detection：UV 254nm
Sample ：DL-P-ydroxyphenylglycine
7

7

L

6

6

Conditions
Column ：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent ：0.1mMCuSO4
Flow rate：1.0
Temp. ：30℃
Detection：UV 254nm
Sample ：D/L 7Alanine
7

D
D

6

min.

6

7

5
5
5

7

6

43

7

6

4

5

6
6

5

4
7
6
2

6
Fig. 6-19 D/L Alanine

Fig. 6-22 Analysis of a trace of L-lactic acid in 50 ppm D-lactic acid

min.

5

4

4

The CRS15W is recommended for analysis of a trace of L-isomer in a principal D-isomerwhen the CRS10W does not provide an adequate chromatogram.

6

5

5

4

6

5

5

5

5

5

4
4
4

4

min.
min.

4
4

L

4

2

4

6

L

3
3

5
8

3
3
3
1

2
4

0.1mM CuSO4
0.5

3
3

D

3
3

3

2
2

CRS15W

D
5

3
3
1

3

2

2

3

2

1
1

CRS10W
2

2

Conditions
Column：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent：2mM CuSO4/CH3CN＝90/10
Flow rate：1.0
Column temp.：ambient2
Detection 2 ：254nm
Sample：1,2＝D,L-p-Hydroxymandelic acid
3,4＝D,L-m-Hydroxymandelic acid
5,6＝D,L-Mandelic acid

Conditions
Column：MCI GEL™ CRS10W 4.6mm I.D.×50mm
Eluent：2mM CuSO4/CH3CN＝90/10
Flow rate：1.0
Column temp.：ambient2
2
Detection：254nmSample：1,2＝D,L-Lactic acid
3,4＝D,L-2-Hydroxy-n-butyric acid
5,6＝D,L-α-Hydroxy-n-valeric acid
7,8＝D-,L-α-Hydroxy isocaproic acid2

1

Fig. 6-21 Separation of DL-alanine

1Fig. 6-18 Separation of 2-hydroxy1carboxylic acids 1

1
Fig. 6-17 Separation of 2-hydroxy1 acids
1
carboxylic

1Comparison data of CRS10W and CRS15W
Application data of CRS10W

37.8

5

1.69

5.0

1.84

6.3

5

5

5

5

middle880-940full range

820-910full range

340-3802〜12790-920

full range＞1000

full range

Small molecules extraction

8

8

＞1.5

CHL20P

Polyamine120

CLB10P

Glucamine

120

10

10

9

Compounds index

Compounds index

10

＞1.8
＞1.0

9

10

Metal Extraction

2-6

9

2-6

Metal Extraction＞3

Extraction
Bron Removal

10

9Compounds index

120

9

TypicalApplication

MCI GEL™ material list

Iminodiaceteic acid

9

Compounds index

CHL10P

Effective
pH range

8

MCI GEL™ material list

Ion exchange
capacity[ meq/]

Compounds index

Mean particle size[μm]

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Functional group7
MCI GEL™ column list

8

6

7

Enrichment of trace oforganic compounds

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

7

6

SPE sorbent series

7

middleName

Compounds index

Compounds
index
分離例化合物
リスト

11
10

MCI GEL™ material list

MCI GELMCI GEL™ material list
充 填 剤一覧

Compounds index

Compounds index

Compounds index

910

MCI GEL™ column list

MCI GELMCI GEL™ column list
カラム一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

98●Chelating type

7

Small molecules extraction
SPE sorbent series

SPE sorbent series

8

25

middle6

SPE sorbent series

120

large

Chiral separation
columns

CSP8006

SPE sorbent series

30

small

6
SPE sorbent series

CHPOD/P30
SPE sorbent series

120

5Chiral separation
columns

pH range

Chiral separation
columns

Surface area
[m2/g]

6

7

5

TypicalApplication

Pore size

CHP87/P120

SFP08/P25

5

5Mean particle size
[μm]

Chiral separation
columns

Name

6

7

Material list

●Synthetic adsorbents and reversed-phase materials

120

7

9

4

CHP85/P120

7

8

4

6

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column listin sample solution is much higher than that of CuSO4 in the eluent.
8
8 both water soluble
8 organic solvents (CH83CN, CH3OH, etc) and non
5. Pleasebe careful not to flow
water soluble organic solvents (n-hexane, chloroform, etc) into the column. The column will be fatally
damaged and will never separate optical isomers. Please be particularly careful if HPLC equipment isused together with RP mode and NP mode.
6. Please do not use acid or alkali solutions to adjust pH of eluent. And also do not use buffer solutions.
These
9 solutions may cause
9 forming precipitation, 9hence cause of blockage
9 of the column.
7. For strongly retained hydrophobic amino acids, addition of CH3CN or CH3OH in the eluent enables
faster elution. The concentration of these organic solvents should be below 15 v/v%.
8. DOPA and other non-polar amino acids will be strongly adsorbed on the packing material and willcause contamination of the column.
9. 10
Regeneration of contaminatedcolumn is difficult.
10
10
10

4

Chiral separation
columns

Chiral separation
columns

SPE sorbent series

SPE sorbent series

SPE sorbent series

1. It will take hours for equilibrium between ligand of stationary phase and copper ion of eluent. Two to
three hours of conditioning the column with the eluent is advised before sample injection or after
7
7
7changing
concentration of7 CuSO4 of eluent.
2. For acidic amino acids, higher CuSO4 concentration of eluent provides better resolution.
3. For weakly retained hydrophilic amino acids, low flow rate (0.2-0.5 mL/min) yields better resolution.
4. Peak area may decrease with continuous injection of samples, when the concentration of amino acids

4

Chiral separation
columns

Chiral separation
columns

6

5

固相吸着剤

Chiral separation
columns

6

Notes

5

4

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

26.4

1.0

Bioseparation columns
and materials

1.0

2.0

5.3

Ion chromatography
columns and materials

2.0

1.85

Ion exchange columns
and materials

22.5

Column selection
guide

1.0

2.6

4

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

2.0

1.64

Bioseparation columns
and materials

10.3

4

4
4

Ion chromatography
columns and materials

1.0

6.5

Ion exchange columns
and materials

2.0

2.16

4

Column selection
guide

24.1

4

4.6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

1.0

6.0

1.97

3

Bioseparation columns
and materials

2.0

1.97

2

Ion chromatography
columns and materials

14.6

Ion exchange columns
and materials

21.9

1.0

6.5

Column selection
guide

0.5

2.0

2.3

2.14

2

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

2.0

1.54

2

Bioseparation columns
and materials

30.4

2

Ion chromatography
columns and materials

16.2

0.5

Ion exchange columns
and materials

1.0

2.0

0.8

3
3

Column selection
guide

2.0

1.18

3

2

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

13.2

4.7

2

Bioseparation columns
and materials

0.5

5.0

2.07

1

・CHP85/P120,CHP87/P120,CHPOD/P30: SPE sorbents with a controlled micro-pore size, high performancesmall molecule adsorption except large molecule mixture, like proteins.
・CSP800: SPE sorbents with high concentration ratio and high recovery, excellent for enrichment traceorganic compounds and non-ionic substances such as trichloroethylene from environmental water.
These SPE sorbents are to prepare samples for mutagenicity study or GC/MS analysis.
・SFP08/P25: SPE sorbents dedicated for small drug molecules extraction.
3
3
3
3
3
Superior purity of this SPE extracts offers easier and faster sample preparation.
・CHL10P,CHL20P,CLB20P: SPE sorbents for rare earth metals that contains chelating functional group.
CLB10P: SPE sorbents for borate, arsenic and selenium ions that contains glucamine groups on highporous ST/DVB matrix.
Ion chromatography
columns and materials

2.0

2.04

3

1

Ion exchange columns
and materials

11.5

Column selection
guide

8.9

1.03

4.5

Chiral separation
columns

59

1.0

1.0

1.1

2.13

6

Compounds index

Compounds index

10

1.0

1.23

6

MCI GEL™ material list

MCI GEL™ material list

9

7.3

6

MCI GEL™ column list

MCI GEL™ column list

8

5

23.8

1.0

1. Column temperature; ambient
Detection; 254nm
2. These are example data and do not guarantee the column specifications.
3. Improved resolution or appropriate chromatogram can be obtained by further investigating
chromatographic conditions.
4. For each amino acid in the table, D-isomer elutes ahead of L-isomer except for Hydroxyproline.

SPE sorbent series

SPE sorbent series

7

5

0.2

1.0

2.3

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

1.0

1.75

1

For a pretreatment of analytical sample, we provide various SPE sorbents with various chemical structure,hydrophobicity, and micro-pore sizes. You can select our SPE sorbents depending on your molecule nature.

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Phe

10.4

1.3

2
2

1

Solid phase extraction sorbents

Bioseparation columns
and materials

21

0.5

1.29

2

1

Ion chromatography
columns and materials

Eth

0.5

11.3

1.0

1

SPE sorbent series

Ion exchange columns
and materials

20

4

0.1

1.25

2

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Tyr

Nleu

10.1

2
0.5

1.7

Bioseparation columns
and materials

Met

19

4

0.5

1.63

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

18

17

0.1

1.4

Bioseparation columns
and materials

4

Leu

10.5

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Ileu(allo)

16

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

15

0.5

Bioseparation columns
and materials

Ileu(DL)

Bioseparation columns
and materials

Glu

14

Bioseparation columns
and materials

Asp

13

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Bioseparation columns
and materials

12

3

0.1

1.39

Analytical and preparative
Bioseparation columns
Chiral separation
columns and materials
生体高分子分離用
医薬精密精chromatography
製 用 充 填 カ ラム
ア ミ ノ酸 D L 分 離 用
and materials
columnsfor pharmaceutical applications
充填カラム及び充填剤
及び充填剤
充填カラム

Nval

11.0

7

Column selection
guide

Val

11 3

0.5

＜1

Ion chromatography

10

0.1

1.45

1
1

イオンクロマトグラフィー用
columns and materials
充填カラム及び充填剤

Pro

7.7

＜1

1

Ion chromatography
columns and materials

Hyp

9

0.2

1.26

Ion chromatography
columns and materials

8

0.1

Ion chromatography
columns and materials

Cit

Ion chromatography
columns and materials

7

6.8

[Rs]

Ion exchange columns

Thr

2

0.2

[α]

イオン交換クロマトグラフィー用and materials
充填カラム及び充填剤

Ser

0.1

1

guide

2

[min]

selection
カラColumn
ム選択の手
引き

6

]

Separationrate

Ion exchange columns
and materials

His•HCI

1

Separation
factorColumn selection
guide

4

[

Retention time;
L-isomers

Ion exchange columns
and materials

Ala

[mM]

1

Flow rate

Ion exchange columns
and materials

3

CuSO4 aq. soln.

Ion exchange columns
and materials

Orn•HCI
Lys•HCI

5

Column selection
guideAmino acids

2

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

Ion exchange columns
and materials

Ion exchange columns
and materials

2

1

Column selection
guideColumn selection
guide

1

Column selection
guideColumn selection
guide

1

Examples of chromatographic conditions and datas

1060Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
Chiral separation
columns

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

及び充填剤

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

Chiral separation
columns

固相吸着剤

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

Compounds index

MCI GEL™ material list

Compounds index

MCI GEL™ material list

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

分離例化合物リスト

Compounds index

0-215-11

Column selection
guide

カラム選択の手引き

Column selection
guide

Ion chromatography
columns and materials

SPE sorbent series

SPE sorbent series

L37, 38
Compounds index

CQP30

10

7.5×600
CQP10

Ion exchange columns
and materials

Chiral separation
columns

Chiral separation
columns

4×50
0-214-11

10

Column selection
guideAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

10

CQP30G
L38

Compounds index

10

Bioseparation columns
and materials

Bioseparation columns
and materials

10

4×50

7.5×600

0-215-01

Ion chromatography
columns and materials

Ion chromatography
columns and materials

10

CQP10G
0-213-110-214-01

Ion exchange columns
and materials

Ion exchange columns
and materials

10

4×50

L25

11

CQP06G
7.5×600
CQP06
0-213-01

8×10

9

62
61

10

0-047-14

10

0-047-13

10

11.5X100

SP01

7.5X100

SP01

4.6X100

Bioseparation for size exclusion

SCA-PC
0-130-22

9

10

10

0-047-11

SP01
0-047-1299911.5X100

9
4.6X50

SP01

9

DA01

9

0-047-03

90-047-02

9

7.5X100

DA01

4.6X100

DA01

4.6X50
DA01

8

8

8

8
8
8

0-047-01

9

4.6X150

88series
XtalSpeed TM 8

20X200CHPOD/C040-504-04
6×50

SCK-PC0-034-21

4.6×309

CDR10G
4.6×250

SCA04G

90-119-11
Ion exchange chromatography anion exchange resin for carboxylic acids and sugars

0-133-12
L31
4.6×150
SCA04/PEEK
0-133-02

4×10

7

0-047-04
Ion chromatography for anions

CA08FG

CDR10

4.6×150

8
CHK45/C05

80-407-01

8

0-111-11
4.6×250

7CA08F

70-119-01

4.6×1506×50
8×10

0-111-01SCK01
0-034-04

CK10SGCK04SSG
0-017-110-003-12
10×200CK04SS0-003-02

6
6

6×50

6×50
8×10

6

SCK01
0-034-01

CK10SGCK04SG
0-017-110-003-11
L58
10×200CK04S
0-003-01

CHPOD/C04

4.6X150

CHK45/C05

4.6X150
CHK40/C04

8×10

60-001-12
20×250CK02AS
0-001-02

7

CK02ASG

0-001-11
L58

0-504-01

L39
CMG20/C10

8×10

7

Ion chromatography for cations

20X2507L39

7

20X1507

CMG20/C10

7

L39

0-202-04

7
0-407-01

610X250
0-202-03

7
7

CMG20/C10

60-202-02

CMG20/C10
0-202-05

60-404-01

7
4×10

L39

6

4.6X250

6L39

6

4.6X150

CMG20/C10
0-202-06

5

5

5

5
4.6X150

L39

5

6

L39

6

20X150

CMG20/C04
0-402-03
CK02AG6

Ion exchange chromatography cation exchange resin for carboxylic acids

CMG20/C04

5

5

5

5

20×250

5

5

5

6×50

CK08EHG
0-010-15
L17
8×300
CK08EH0-010-05

L19

0-402-05

4
4
4
4

CK02A

0-406-04

4

6×50

8×300
7.8×300
CK08EC0-010-02
0-010-07

7.8×300
0-010-08

50-001-01

0-406-03

4

CK08ESG
8×300
CK08ES
0-010-03

4

Ion exchange chromatography cation exchange resin for oligosaccharides

20X250

CHP07/C10

20X150

CHP07/C10

10X150

CHP07/C10

46×50

0-010-13

CK08ECG

4

6×50
0-010-12

CK08EG
0-010-11
L58

3
8×300
7.8×300

3CK08E
0-010-01
0-010-06

30-406-02

4 4.6X250

4
4

3

6×50

L58

3

0-406-01

40-405-06

3
11.5X100
L21

CK08SG

30-009-11
8×500
CK08S
0-009-01

CHP07/C10

4.6X150

CHP07/C10

20X200

CHP07/C040-405-04

3CM01
320X250
30-403-04 3

3

4.6X1500-047-34

L21
CHP20/C10

20X150

CHP20/C10
0-403-03

Ion exchange chromatography cation exchange resin for sugars

CHP07/C04

7.5X100

4.6X100

6×50
AFR2-PC0-033-21
6×120
CK10U
0-019-01

0-405-01

CM01

CM01

L21

11.5X10022
Ion exchange chromatography cation exchange resin for amino acids

30-047-33

4.6X500-047-32

CM01

0-047-31
10X250Q0 1

0-047-24
L21
4.6X150

CHP20/C10
0-403-05

2

CHP20/C10

7.5X100

20-047-2322

20-403-02

Q0 1

L21

2
2
2

20X150

CHP20/C04
0-401-03
Name
Code No.
USP
Name
Code No.

L21

4.6X100

L21
Column dimensions[mm]

Column dimensions[mm]

4.6X250Q0 1

0-047-22

4.6X150

CHP20/C04
0-401-05

Guard/Pre-column

Main column

CHP20/C10

2

4.6X502

Column selection
guideColumn selection
guide

1

1

0-403-012

Q0 1

0-047-21

series
XtalSpeed

11
18 MCI GEL™ column list

TM

1
1
1
1

1

1

1

USP
Column dimensions
[mm]

Name

Code No.
USP
Column dimensions
[mm]

Name
Code No.

1
Analytical and preparative chromatography columns
for pharmaceutical applications [CHP column series]

Main column
Main column

Column selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guideColumn selection
guide

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

Ion exchange columns
and materials

Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Column selection
guide

カラム選択の手引き

Column selection
guideColumn selection
guideColumn selection
guide

Ion chromatography
columns and materials

Ion chromatography
columns and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

及び充填剤

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

固相吸着剤

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

SPE sorbent series

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ material list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

MCI GEL
カラム一覧

MCI GEL™ material list

Compounds index

Compounds index

Compounds index

Compounds index

10

10

10

Compounds index

Compounds index

Compounds index

Compounds index

分離例化合物リスト

Compounds index

Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL充 填 剤一覧

MCI GEL™ material list

MCI GEL™ material list

Compounds index

10Compounds index

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9

9

64
63

5

8
8

10 ＝ Styrene-divinylbenzene
10 copolymer
Abbreviation; ST/DVB
10

8 AFR2

8

7

8

10

50

7

8

10
10

RSO3-

CK10Y

7

1-021-01

7

8

11
10

＞2.7
25

8 ST/DVB

5

1-033-01

CK12U

7

1-024-02

3

7 CK10M

7

9

−
H+

RSO3-

8

ST/DVB

5
1-020-05

9

＞4.3
25

RSO3-

CK10M
1-020-06

5
1-019-04

9

10
Na+

ST/DVB

10

7

CK10U

CK10U

1-019-03

9

＞4.3
5

RSO3-

3

7

9

12
Na+

ST/DVB

CK10U

61-019-01

6
6
6

9

＞4.3

RSO3-

10

CK10F

5

6
CK10F

6

9

10
4

ST/DVB

7

Na+

RSO3-

6

10

8
Ammonia trap

＞4.3
5

8

10
Na+

ST/DVB

6

CK10S

1-017-03

6

7

5

1-018-02105

1-017-02

CK10S

1-017-015

5

Mitsubishi Chemical has been supplying packing materials for more than 50 years.

1-018-01

6

5 CK10S

5100
1-014-01

5

50

RSO3-

5

ST/DVB
25

CK08P

5

9

Amino acids

＞4.3

8

Amino acids

7

Amino acids

10
Na+

7

＞4.3
11

5

Na+

6

10

7

6
Amino acids

6

Amino acids

＞1.8
120
RSO3-

300

5

9
9

5 Carboxylic acids,

8
H+
ST/DVB

50
CK08Y

1-013-02

50

4

CK08E

1-010-03

CK08Y
1-013-01

25

CK08E

Amino acids

5

Sugars, Carboxylic acids(meq/ )

＞4.40
25
ST/DVB

RSO3-

4．Abundant experience

9

Sugars, Carboxylic acids
8

4

50

Na+

RSO3-

4

CK08S

1-009-03

CK08S

control.

4101-009-02

ST/DVB

1-010-02

25

CK08S

3

1-009-01

3

10

4

50

4

4

9

CK06S

1-004-03

CK06S

4

＞4.40

Sugars, Carboxylic acids

8
Na+

10

3
3
3
Produced with Mitsubishi Chemical’s excellent technology, experienceand under strict 3quality

1-010-01

3．Wide range of product line

CK06S

1．Excellent performance

CK08E

4

3

Sugars, Carboxylic acids

＞4.40
11

1-004-01

2．Persistence and highest quality

3

4
MCI GEL™ packing materials include ion exchange
resins (cation and anion), non-functionalizedpolymer used for reversed phase
chromatography
and
other
varieties of
4 products. Also MCI 4GEL™
4offers mean particle size of 4 μm to approximately 300 μm packing materials, this means that
MCI GEL™ products are applied to analysis use and preparative use.

3

8
Na+

3

RSO3-

2 CK04S
2

3

ST/DVB

1-003-03

2
2

3

＞4.45

Oligosaccharides
6
11
25

2
2

1-003-02

CK04S

1-003-01

Characteristics

1-004-02

50

Na+

2
Sphere packing and sharp particle size distribution provide high performance.

10

RSO3-

2

11
RSO3-

2

2

Na+
ST/DVB

25

2

＞4.5

20
RSO3CK04S

2

4

Oligosaccharides＞4.5

Oligosaccharides

2
Na+
ST/DVB

1
1

9

ST/DVB

3

1
1

2

1

10

1

1

1
1

CK02A

1

Ion exchange
capacity
Typical Application
[
g]

Cross
linkage
1 [%]Mean
Functional
Counter ion particle size
group
[μm]

Base material

Packing
size
[g]
Name

Code No.

11-001-01

1●Ion exchange chromatography cation exchange resins［CK series, AFR series］

MCI GEL™ material list

1-219-01
1-317-01

8
Packingsize

9

CHP85/P120
CHP87/P120
CHPOD/P30
CSP800
SFP08/P25

9

Meanparticle
8size
[μm]

Pore size

100mL
100mL
100g

120
120
30

Middle
Small
Large

50mL

120

Middle50g

259

Middle7

8pH range
Full range
Full range
2〜12
Full range

9Full range

10

CHL10P
CHL20P
CLB10P

Packing size
100g

10 100g
100g

Functional
group

Particle size

Iminodiacetic acid10
Polyamine
Glucamine

120
120
120

Excange
capacity＞1.5

10＞1.8＞1.0

Reversed-phase
chromatography

8 Application
TypicalSmall molecules extraction
Enrichment of trace oforganic compounds
Small molecules
extraction
9

Typical Application
Metal Extraction
10Extraction
Metal
Bron Removal

6

7

8

9
Compounds index

1-601-02
1-602-02
1-603-02

Product Name

Reversed-phase
chromatography

Compounds index●Chelating resins for solid phase extraction in pretreatment
Code No.

Reversed-phase

6 chromatography

5

MCI GEL™ material list

1-315-02
1-316-02
1-505-02

8 Product Name

Reversed-phase
chromatography

MCI GEL™ column list

Code No.

5

Reversed-phase
chromatography

SPE sorbent series●Synthetic adsorbent and reversed-phase materials

Reversed-phase
chromatography

Chiral separation
columns

ST/DVB＝Styrene-divinylbenzene copolymer

4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

7

7

Bioseparation columns
and materials

2〜12

Ion chromatography
columns and materials

25

Ion exchange columns
and materials

150

Column selection
guide

2〜12

4

Reversed-phase
chromatography

MCI GEL™ material list

10

25

3

Reversed-phase

MCI GEL™ column list

10

30

2〜12

6

3 chromatography

Reversed-phase
chromatography

SPE sorbent series

10＝ Diethylaminoethyl
DEAE

25

full range

2

chromatography

Chiral separation
columns

Proteins

10

5

2 Reversed-phase

Reversed-phase
chromatography

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

CM11＝ Carboxymethyl

＞4

25

1

Bioseparation columns
and materials

SP ＝ Sulfopropyl

60

MA

120

full range

Reversed-phase

1 chromatography

Ion chromatography
columns and materials

10 ＝ Polyhydroxymethacrylate
Abbreviations; HMA
QA ＝ Quaternary ammonium

30

100
1,000
710,000
50,00025

Typical Application

Ion exchange columns
and materials

HMA

Proteins

MA

10

6

full range

Column selection
guide

100

1〜13

25
100
1,000

25

Compounds index

CQK31P

分離例化合物リスト

1-039-01

60

CMG20/P30
CMG20/P30
CMG20/P30

30

MCI GEL™ material list

CM

Na+

30

MA

4

MCI GEL™ column list

Na+

10g

full range

SPE sorbent seriesSP

Proteins

95full range

3

Chiral separation
columns

HMA

2〜12

9

25

full range

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

100

Proteins

20

full range

Bioseparation columns
and materials

CQK30P

60

＜11

45

full range

Ion chromatography
columns and materials

1-037-0130

9

6 1,000

Abbreviations; MA＝Polymethacrylate120

1
Ion exchange columns
and materials

QA

60

7

45

4

CMG20/P10
CMG20/P10

CMG20/P150
CMG20/P150
CMG20/P150
CMG20/P150

Column selection
guide

HMA

30

1-308-02
1-308-03
1-308-04
1-308-05

70

Compounds index

100

Cl-

1-306-06
1-306-07
1-306-08

6452

MCI GEL™ material list

CQA35P

DEAE

ST/DVB

1-309-01
1-309-03

50

MCI GEL™ column list

1-131-01

10
Cl-

9

100
1,000
10,00050,000Compounds index

HMA

ST/DVB

Compounds index

100

Typical Application

Compounds index

CQA31P
9

pH range

Compounds index

1-127-01

Compounds index

Base material

Code No.

Compounds index

Compounds index

Name

Packing
size
[
]

10g
1,000

5

45

SPE sorbent series

Mean
Functional
Pore size
Counter ion particle size
[nm]
group
[μm]

ST/DVB

CHP07/P120
CHP07/P120
CHP07/P120
CHP07/P120

30

Chiral separation
columns

MCI GEL™ material list

MCI GEL充 填 剤一覧●Bioseparation columns -Ion exchange materials［CQA series, CQK series］
9

25
100
1,000

5

full range

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

8

CHP50/P30
CHP50/P30
CHP50/P30

MCI GEL™ material list

8

MCI GEL™ material list

Compounds index

81-303-06
1-303-07
1-303-08

1-314-02
1-314-03
1-314-04
1-314-05

45

3

ST/DVB

CSP50/P10
CSP50/P10

20

Bioseparation columns
and materials

Water soluble polymer

ST/DVB25
100
4 1,000

1-312-01
1-312-03

pH range

Ion chromatography
columns and materials

1×106

MCI GEL™ material list

8

MCI GEL™ material list

MCI GEL™ material list

860

Typical Application

100
500
1,000
10,00050,0003

Pore size[nm]

Ion exchange columns
and materials

Abbreviation; HMA ＝ Polyhydroxymethacrylate

30

limit

Column selection
guide

HMA

7 Exclusion

ST/DVBMCI GEL™ column list

100

Pore size
[nm]

500
1,000
10,000SPE sorbent series

CQP30P

Mean
particle size[μm]

MCI GEL™ column list

Base material

MCI GEL
カラム一覧

Packingsize[ ]ST/DVB2

MCI GEL™ material list

7
MCI GEL™ column list

7

Name

MCI GEL™ material list

1-222-01

7

2 100g

CHP50/P20
CHP50/P20
CHP50/P20

MCI GEL™ column list

7

●Bioseparation columns -Size exclusion chromatography materials-［CQP series］

ST/DVBMean
particle size[μm]

11-304-06
1-304-07
1-304-08 4

SPE sorbent series

SPE sorbent series

7

MCI GEL™ column list

QA ＝ Quaternary ammonium

6

25
100
1,000

Chiral separation
columns

6

ST/DVB

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Anion analysis

CHP20/P120
CHP20/P120
CHP20/P120
CHP20/P120
CHP20/P120

25
100
1,000

1

Bioseparation columns
and materials

30

SPE sorbent series

HMA ＝ Polyhydroxymethacrylate

6
SPE sorbent series

MCI GEL™ column list

Abbreviations; ST/DVB ＝ Styrene-divinylbenzene copolymer

5

3

CHP20/P70
CHP20/P70
CHP20/P70

Basematerial

Ion chromatography
columns and materials

6

Cl-

Cation analysis

CHP20/P50

Packingsize[ ]Ion exchange columns
and materials

10

QA

固相吸着剤

6 SCA04

HMA

25

5

1-311-01
1-311-02
1-311-03
1-311-04
1-311-05

2

Chiral separation
columns

5

5
Typical Application

1-313-02
1-313-03
1-313-04

CHP20/P30
CHP20/P30
CHP20/P30

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SCA04

6

11

4

Chiral separation
columns10

H+

4

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

SCK01

Mean
Ion exchange
particle size 5 capacity[μm][μeq／g]Counter ion

RSO3-

Nucleic acids, Sugars

Chiral separation
columns

ST/DVB＞0.3

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Functional
group

Sugars, Carboxylic acids

4

Chiral separation
columns

SCK01

ア ミ ノ酸 D L 分 離 用
充填カラム

1-034-025
Base material

5 Name5Chiral separation
columns

1-034-01

Packing
size
[g]

＞1.2

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

QA；Quaternary ammonium

Sugars, Carboxylic acids

1-310-01

CHP20/P20
CHP20/P20
CHP20/P20

Column selection
guide

−

＞1.3

1-305-06
1-305-07
1-305-08

Product Name

1

Bioseparation columns
and materials

7

3

Sugars, Carboxylic acids

1-307-06
1-307-07
1-307-08

Ion chromatography
columns and materials

Cl-4

3

＞1.2

Code No.

Ion exchange columns
and materials

QA

2●Analytical and preparative chromatography materials for pharmaceutical applications［CHP material series］
Column selection
guide

10

2

Bioseparation columns
and materials

11

Sugars, Carboxylic acids

Ion chromatography
columns and materials

QA

Cl-

3

＞1.2

Ion exchange columns
and materials

8

Sugars, Carboxylic acids

Column selection
guide

4

120

＞1.2

1

Bioseparation columns
and materials

43

Sugars, Carboxylic
acids
1

Ion chromatography
columns and materials

ST/DVBCl-＞1.2

Ion exchange columns
and materials

7
14

QA

Bioseparation columns
and materials

CDR10
CDR10

3

Cl-

2
Ion chromatography
columns and materials

ST/DVB

8

QA

Ion exchange
capacity
Typical Application[]

Ion exchange columns
and materials

10
25
50

Column selection
guide

CA10S
CA10S
CA10S

25

Cl-

医 薬 精 密 精 製 用 充 填 カ ラム

ST/DVB

8

QA

及び充填剤

100

7

2

生体高分子分離用
充填カラム及び充填剤

CA08P

8

イオンクロマトグラフィー用
充填カラム及び充填剤

311

イオン交換クロマトグラフィー用
充填カラム及び充填剤

ST/DVBCl-

Column selection
guide

カラム選択の手引き

50

MCI GEL™ column list

MCI GEL™ column list

65

CA08Y

QA

2

SPE sorbent series

SPE sorbent series

10

ST/DVB

Chiral separation
columns

Chiral separation
columns

9

5
10

61

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Code No.

Code No.

8

CA08F
CA08F

2

11

1

●Ion chromatography materials［SCA, SCK series］

1-133-02

7

ST/DVBCl-

Abbreviations； ST/DVB＝styrene-divinyl benzene copolymer

1-133-01

6

10
25
50

QA

1

Bioseparation columns
and materials

1-119-01
1-119-02

CA08S
CA08S
CA08S

Cross
linkage[%]Ion chromatography
columns and materials

1-116-01
1-116-02
1-116-03

CA06S
CA06S

Mean
Functional
Counter ion particle size
group
[μm]

Ion exchange columns
and materials

1-113-01

Column selection
guide1-112-01

Base material
ST/DVB

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

1-111-01
1-111-02

Packing
size
[g]
10
25
50

Bioseparation columns
and materials

Bioseparation columns
and materials

4

1-109-01
1-109-02
1-109-03

1CA06S

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

1-104-01
1-104-02
1-104-03

Name

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Code No.

Column selection
guideColumn selection
guide

1

●Ion exchange chromatography anion exchange resins［CA series, CDR series］

10
66

1

2
Ion chromatography
columns and materials

3
Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6
SPE sorbent series

SPE sorbent series

SPE sorbent series

7
MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9Compounds index

Compounds index

Compounds index

50
25
25
25
25
47
52
27
50
19
22
24
26
26
26
27
27
12
12
37
40
42
36
11
19
20
21
21
21
21
25
42
38
52
21
17
24
45
48
21
45
48
32
40
42
46
37
38
19
22
56
56
56
50
12
12
12
36
52
24
39
36
50
36
50

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

5-36
3-7
3-8 1
3-9
3-10
5-28
5-40
3-14
5-36
2
2-38
2-45
3-1
3-11
3-12
3-13
3-14
3
3-16
2-16
2-18
5-7
5-13
5-18
5-5
4
2-13
2-39
2-40
2-44
2-44
2-43
2-44
5
3-8
5-19
5-9
5-39
2-43
2-32
3-6 6
5-25
5-33
2-43
5-25
5-33
4-6
5-13 7
5-18
5-26
5-7
5-9
2-38
2-45
6-16 8
6-16
6-16
5-34
2-16
2-18
2-17
5-3 9
5-40
3-2
5-10
5-3
5-34
5-3
5-34 10Page

Column selection
guideFigureIon exchange columns
and materials

CHP50/P20
SCK01
SCK01 1
SCK01
CHK45/C05
CHK40/C04
CMG20/C10
SCA04
CHP50/P20
2
CA08F
CDR10
SCK01
SCA04
SCA04
SCA04
SCA04
3
SCA04
CK08EH
CK08EH
CHP20/C04
CMG20/C04
CMG20/C10
CHP20/C04
4
CK08EH
CA08F
CA08F
CDR10
CDR10
CDR10
CDR10
5
SCK01
CHP20/C10
CHP20/C04
CMG20/P30
CDR10
CK10U
SCK01 6
CHK40/C04
CHK45/C05
CDR10
CHK40/C04
CHK45/C05
CQP30
CMG20/C04
7
CMG20/C10
CMG20/C10
CHP20/C04
CHP20/C04
CA08F
CDR10
CRS10W
8
CRS10W
CRS10W
CHP50/P20
CK08EH
CK08EH
CK08EH
CHP20/C04
9
CMG20/C10
SCK01
CMG20/C04
CHP20/C04
CHP50/P20
CHP20/C04
10
CHP50/P20

Ion exchange columns
and materials

Compounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

Ion exchange columns
and materials

2

Caffeine
Calcium ion
1
Calcium ion
Calcium ion
CationCandesartan
Alkaloid
Carbonate ion
Catechin2
Cellobiose
Cellobiose
Cation
Anion
Anion
Anion
Anion
3
Anion
Carboxylic acid
Carboxylic acid
Bile acid
ProteinProtein
Cinchona alkaloid
4
Carboxylic acid
Carboxylic acid
Carboxylic acid
Nucleotide
Nucleotide
Nucleotide
Nucleotide
5
CationProtein
Adrenal cortical hormone
CrocinNucleotide
Amino acid
Nucleoside
6
Nucleoside
Nucleoside
Nucleic base
Nucleic base
Nucleic baseProteinProtein7
Protein
PerfumeBile acid
Adrenal cortical hormone
Deoxysugar
Deoxysugar
D,D-Diamino carboxylic
8 acidL,L-Diamino carboxylic acidmeso-Diamino carboxylic acidAromatic ester
Carboxylic acid
Carboxylic acid
Polyalcohol
Aromatic ester
9
Alkaloid
Amine
Medicine
Aromatic ester
Aromatic ester
Aromatic ester
10
Aromatic ester

MCI GEL™ column

Column selection
guide1
Ion exchange columns
and materials

Compounds index

Compounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Ion chromatography
columns and materials

3

Ion exchange columns
and materials

2
Ion chromatography
columns and materials

Ion chromatography
columns and materials

Compounds index

11
12
12
19
2 20
20
20
11
11
56
3 56
21
45
48
24
45
48
4 7
21
17
18
18
58
57
5 58
57
18
50
24
24
24
6 25
21
21
21
21
21
48
7 41
40
39
17
20
17
55
8 56
55
56
39
21
25
26
9 26
44
44
11
11
25
36
1039

Ion exchange columns
and materials

Page
Ion exchange columns
and materials

MCI GEL™ material list

Compounds index

分離例化合物リスト

10

MCI GEL™ column list

MCI GEL™ material list

MCI GEL充 填 剤一覧9

SPE sorbent series

MCI GEL™ column list

MCI GEL
カラム一覧

8

Chiral separation
columns

SPE sorbent series

7

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Chiral separation
columns

固相吸着剤

6

Bioseparation columns
and materials

ア ミ ノ酸 D L 分 離 用
充填カラム

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

医 薬 精 密 精 製 用 充 填 カ ラム

5

及び充填剤

4

2-13
2-16
2-18
2-39
2-40
2-41
2-42
2-14
2-14
6-14
6-14
2-43
5-25
5-33
3-6
5-25
5-33
2-1
2-43
2-32
2-36
2-33
6-21
6-19
6-21
6-19
2-34
5-35
3-2
3-1
3-3
3-10
2-43
2-44
2-44
2-43
2-44
5-33
5-17
5-12
5-10
2-32
2-41
2-32
6-5
6-15
6-5
6-15
5-10
2-43
3-7
3-11
3-12
5-22
5-22
2-15
2-15
3-8
5-4
5-10

Ion chromatography
columns and materials

Bioseparation columns
and materials

生体高分子分離用
充填カラム及び充填剤

3Figure

CK08EH
CK08EH
CK08EH
CA08F
2
CA08F
CA08F
CA08F
CK08EH
CK08EH
CRS10W
CRS10W
3
CDR10
CHK40/C04
CHK45/C05
SCK01
CHK40/C04
CHK45/C05
CK08EC
4
CDR10
CK10U
CK10U
CK10U
CRS10W/CRS15W
CRS10W
CRS10W/CRS15W 5
CRS10W
CK10U
CHP50/P20
SCK01
SCK01
SCK01
CHK45/C05
6
CDR10
CDR10
CDR10
CDR10
CDR10
CHK45/C05
CHP20/C10
7
CMG20/C04
CMG20/C04
CK10U
CA08F
CK10U
CRS10W
CRS10W
8
CRS10W
CRS10W
CMG20/C04
CDR10
SCK01
SCA04
SCA04
9
CHP20/C10
CMG20/C10
CK08EH
CK08EH
SCK01
CHP20/C04
10
CMG20/C04

Ion exchange columns
and materials

Ion chromatography
columns and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

2

MCI GEL™ column

Caffeine
Calcium ion
1ion
Calcium
Calcium ion
Calcium ion
Candesartan
Capsaicin
Carbonate ion
Catechin2
Cellobiose
Cellobiose
Cesium ion
Chloride ion
Chloride ion
Chloride ion
Chloride ion
3
Chloride ion
Chloroacetic acid
Chloroacetic acid
Cholic acid
α-Chymotrypsinogen A
α-Chymotrypsinogen A
Cinchonine
4
Citric acid
Citric acid
Citric acid
2'-CMP
3'-CMP
5'-CMP
5'-CMP
5
Cobalt ion
Conalbumin
Corticosterone
Crocin3',5'-Cyclic AMP
CystineCytidine
6
Cytidine
Cytidine
Cytosine
Cytosine
Cytosine
Cytochrome c
Cytochrome
7 c
Cytochrome cβ-Citronellool
Deoxycholic acid
11-Deoxycortisol
Deoxyribose
Deoxyribose
D,D-2,6-Diaminopimelicacid
8
L,L-2,6-Diaminopimelic acidmeso-2,6-Diaminopimelic acid
Dibutyl phthalate
Dichloroacetic acid
Dichloroacetic acid
Diethylene glycol
Diethyl9phthalate
Dihydrocapsaicin
Dimethylamine
4-Dimethylaminoantipyrine
Dimethyl phthalate
Dimethyl phthalate
Dipropyl phthalate
10phthalate
DipropylClassification

Column selection
guide

1

61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125

Column selection
guideColumn selection
guide

1

CompoundColumn selection
guideColumn selection
guide

1

Column selection
guideColumn selection
guideClassification

Acetic acidAcetic acidAcetic acid2
Acetic acidAcetic acidAcetic acidAcetic acid
N-Acetylgalactosamine
N-Acetylglucosamine
Acetyl-D-Met.
3
Acetyl-L-Met.
Nucleic base
Nucleic base
Nucleic base
Nucleoside
Nucleoside
4
Nucleoside
Adonitol
Nucleotide
AlanineAmino acid
β-Alanine
D-Alanine5
D-Aminoacid
L-Alanine
L-Amino acidγ-Aminobutyric acid
6-Aminopenicillanic acid
Ammonia
6
CationCationCationNucleotide
Nucleotide
Nucleotide
7Nucleotide
Nucleotide
Nucleotide
Amphotericin B
Angiotensin II
Antipyrine
Arginine
Carboxylic acid
Aspartic acid
D-Aspartic acid
D-Amino acid
L-Aspartic acid9
L-Aminoacid
Aspirin
Nucleotide
Barium ion
Bromide ion
Bromide ion
10
BuserelinBuserelin
n-Butyl alcohol
sec-Butyl alcohol
Cadmium ion
Caffeine
11
Caffeine

1
Ion exchange columns
and materials

イオン交換クロマトグラフィー用
充填カラム及び充填剤

Compounds index

67

Compounds index

MCI GEL™ material list

10

MCI GEL™ material list

MCI GEL™ column list

9

MCI GEL™ column list

SPE sorbent series

8

Chiral separation
columns

Chiral separation
columns

7

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

6

Bioseparation columns
and materials

Bioseparation columns
and materials

5

Acetic acidAcetic acidAcetic acidAcetic acid2
Acetic acidAcetic acidAcetic acid
N-Acetylgalactosamine
N-Acetylglucosamine
Acetyl-D-Met.
Acetyl-L-Met.
3
AdenineAdenineAdenineAdenosine
Adenosine
Adenosine
Adonitol
45'-ADP
Alanine
Alanineβ-Alanine
D-Alanine
D-Alanine
L-Alanine5
L-Alanineγ-Aminobutyric acid
6-Aminopenicillanic acid
Ammonia
Ammonium ion
Ammonium ion
Ammonium ion
62'-AMP
2'-AMP
3'-AMP
5'-AMP
5'-AMP
AMP
Amphotericin B
7
Angiotensin II
Antipyrine
Arginine
Ascorbic acid
Aspartic acid
D-Aspartic acid
D-Aspartic acid8
L-Aspartic acid
L-Aspartic acid
Aspirin
5'-ATP
Barium ion
Bromide ion
Bromide ion
9BuserelinBuserelin
n-Butyl alcohol
sec-Butyl alcohol
Cadmium ion
Caffeine
Caffeine
Ion chromatography
columns and materials

Ion chromatography
columns and materials

4

Compound
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60

Ion exchange columns
and materials

Ion exchange columns
and materials

3

1

1

Column selection
guideColumn selection
guideColumn selection
guide

1

2

カラム選択の手引き

10 Compounds index

10
68

Page

1

2
Ion chromatography
columns and materials

3
Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6
SPE sorbent series

SPE sorbent series

SPE sorbent series

7
MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9Compounds index

Compounds index

Compounds index

10
11
16
16
16
19
22
32
17
55
55
8
9
11
17
11
12
38
40
21
21
21
24
45
45
48
48
17
55
55
30
30
18
38
36
57
57
57
57
18
57
57
57
57
57
57
57
57
18
37
45
48
21
45
48
43
43
43
43
47
17
18
54
54
54

Ion exchange columns
and materials

Ion chromatography
columns and materials

Ion chromatography
columns and materials

2-12
2-14
2-28 1
2-29
2-30
2-38
2-45
4-7
2-32
2
6-6
6-6
2-8
2-9
2-15
2-32
2-13
3
2-18
5-8
5-12
2-44
2-44
2-43
3-6
4
5-25
5-25
5-33
5-33
2-32
6-7
6-7
5
4-2
4-2
2-35
5-9
5-2
6-17
6-17 6
6-17
6-17
2-37
6-17
6-17
6-18
6-18 7
6-18
6-18
6-20
6-20
2-35
5-6
5-25 8
5-33
2-44
5-25
5-33
5-20
5-20
5-209
5-20
5-28
2-32
2-36
6-1
6-1
6-1 10Ion exchange columns
and materials

Ion exchange columns
and materials

CK08E
CK08EHCK04S 1
CK04S
CK04S
CA08F
CDR10
CQP06
CK10U
2
CRS10W
CRS10W
CK08ECCK08ECCK08EHCK10U
CK08EH
3
CK08EH
CHP20/C04
CMG20/C04
CDR10
CDR10
CDR10
SCK01
4
CHK40/C04
CHK40/C04
CHK45/C05
CHK45/C05
CK10U
CRS10W
CRS10W
5
SP01
SP01
CK10U
CHP20/C04
CHP20/C04
CRS10W
CRS10W6
CRS10W
CRS10W
CK10U
CRS10W
CRS10W
CRS10W
CRS10W7
CRS10W
CRS10W
CRS10W
CRS10W
CK10U
CHP20/C04
CHK40/C04
8
CHK45/C05
CDR10
CHK40/C04
CHK45/C05
CHP20/C10
CHP20/C10
CMG20/C10
9
CMG20/C10
CHK40/C04
CK10U
CK10U
CRS10W
CRS10W
CRS10W10

FigureColumn selection
guide

MCI GEL™ column

Column selection
guideColumn selection
guideCompounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Sugar
Sugar
1
Sugar
Sugar
Sugar
Sugar
Sugar
Sugar
Amino acid2
D-Amino acid
L-Amino acid
Polyalcohol
Polyalcohol
Polyalcohol
Amino acid
Carboxylic acid3
Carboxylic acid
Glycyrrhizic acid
PeptideNucleotide
Nucleotide
Nucleotide
Nucleoside
4
Nucleoside
Nucleoside
Nucleoside
Nucleoside
Amino acid
D-Amino acid
L-Amino acid5
ProteinProteinAmino acid
Adrenal cortical hormone
Amino acidD-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic6acid
D-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acid
Amino acidD-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic
7 acidD-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acid
D-Amino acid
L-Amino acid
Amino acid
6-Hydroxypurine
Nucleic base
8
Nucleic base
Nucleotide
Nucleoside
Nucleoside
PeptidePeptidePeptide9
PeptideSartanAmino acid
Amino acid
D-Amino acid
L-Amino acid10
D-Amino acidIon chromatography
columns and materials

Ion chromatography
columns and materials

3

Classification

Ion exchange columns
and materials

2

Column selection
guide1
Ion exchange columns
and materials

Compounds index

Compounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

GlucoseGlucose1
GlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlutamic acid2
D-Glutamic acid
L-Glutamic acid
Glycerol
Glycerol
Glycerol
GlycineGlycolic acid3
Glycolic acid
Glycyrrhizic acid
Gly-Tyr
3'-GMP
5'-GMP
5'-GTP
Guanosine4
Guanosine
Guanosine
Guanosine
Guanosine
Histidine
D-Histidine
L-Histidine
5
Hemoglobin A0
Hemoglobin A1c
5-HPA
Hydrocortisone
5-Hydroxytryptophan
D-2-Hydroxy-n-butyric acid
L-2-Hydroxy-n-butyricacid
6D-α-Hydroxy isocaproic acid
L-α-Hydroxy isocaproic acid
5-hydroxy lysine
D-α-Hydroxy-n-valeric acid
L-α-Hydroxy-n-valeric acid
D-m-Hydroxymandelic acid
L-m-Hydroxymandelicacid
7
D-p-Hydroxymandelic acid
L-p-Hydroxymandelic acid
D-P-Hydroxy phenylglycine
L-P-Hydroxy phenylglycine
Hydroxy proline
Hypoxanthine
Hypoxanthine
8
Hypoxanthine
5'-IMP
InosineInosineInsulin human recombinantInsulin glargine
Insulin 9
human recombinantInsulin glargine
Irbesartan
Isoleucine
Isoleucine
D-Isoleucine
L-Isoleucine10
allo-D-Isoleucine
Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255

Ion exchange columns
and materials

Ion exchange columns
and materials

2

CompoundColumn selection
guide

1

Column selection
guideColumn selection
guideAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Compounds index

Compounds index

10

36
50
1 50
50
50
36
8
9
9
2 7
55
55
8
11
9
11
3 12
32
41
26
26
11
19
4
20
7
7
8
8
8
5 8
8
9
9
10
16
16
6 16
19
22
16
19
7
10
7 12
19
22
50
48
7
9
8 46
43
43
20
20
32
7
9 7
8
8
8
8
8
9
10 9
Bioseparation columns
and materials

9

5-2
5-36
5-36
5-36
5-36
5-2
2-8
2-9
2-10
2-1
6-2
6-2
2-8
2-15
2-9
2-15
2-17
4-6
5-17
3-11
3-12
2-13
2-39
2-41
2-1
2-2
2-4
2-5
2-6
2-7
2-8
2-9
2-10
2-11
2-28
2-29
2-30
2-38
2-45
2-30
2-38
2-3
2-11
2-19
2-38
2-45
5-36
5-33
2-1
2-10
5-26
5-21
5-21
2-40
2-42
4-7
2-1
2-2
2-4
2-5
2-6
2-7
2-8
2-9
2-10

Page

Ion chromatography
columns and materials

8

FigureIon exchange columns
and materials

7

MCI GEL™ material list

MCI GEL™ material list

分離例化合物リスト

10

6

MCI GEL™ column list

MCI GEL™ column list

MCI GEL充 填 剤一覧95

SPE sorbent series

SPE sorbent series

MCI GEL
カラム一覧

8

4

Chiral separation
columns

Chiral separation
columns

固相吸着剤

7

3

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

ア ミ ノ酸 D L 分 離 用
充填カラム

6

2

Bioseparation columns
and materials

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

5

及び充填剤

4

1

Ion chromatography
columns and materials

Ion chromatography
columns and materials

生体高分子分離用
充填カラム及び充填剤

3

CHP20/C04
CHP50/P20
CHP50/P20
CHP50/P20
CHP50/P20
CHP20/C04
CK08ECCK08ECCK08ECCK08ECCRS10W
CRS10W
CK08ECCK08EH
CK08ECCK08EH
CK08EH
CQP30
CHP20/C10
SCA04
SCA04
CK08EH
CA08F
CA08F
CK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08EC
CK04S
CK04S
CK04S
CA08F
CDR10
CK04S
CA08F
CK08ECCK08ECCK06SC
CA08F
CDR10
CHP50/P20
CHK45/C05
CK08ECCK08EC
CMG20/C10
CMG20/C10
CMG20/C10
CA08F
CA08F
CQP06
CK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECCK08ECIon exchange columns
and materials

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

2

MCI GEL™ column

Column selection
guide

1

Column selection
guideColumn selection
guideClassification

Catecholamine
1
Catechol
Catechol
Catechol
Catechol
Catecholamine
Sugar alcohol
Sugar alcohol
2 alcohol
Sugar
Sugar alcohol
D-Amino acid
L-Amino acid
Alcohol
Alcohol
Alcohol
3
Polyalcohol
Polyalcohol
Protein
Antibiotic
Anion
Anion
4
Carboxylic
acid
Carboxylic acid
Carboxylic acid
Sugar
Sugar
Sugar
Sugar
5
Sugar
Sugar
Sugar
Sugar
Sugar
Sugar
6
Sugar
Sugar
Sugar
Sugar
Sugar
Fructo-oligosaccharide
7Sugar
Sugar
Sugar
Sugar
Sugar
Sugar
Catechol
Nucleotide
Disaccharide
Disaccharide
Perfume
Peptide9
PeptideCarboxylic acid
Carboxylic acid
Carboxylic acid
Sugar
Sugar
10
Sugar
Sugar
Sugar
Sugar
Sugar
Sugar
11
Sugar
イオン交換クロマトグラフィー用
充填カラム及び充填剤

69

カラム選択の手引き

Compounds index

10Compounds index

MCI GEL™ material list

9

MCI GEL™ material list

MCI GEL™ column list

8

MCI GEL™ column list

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Dopamine
Epicatechin
Epicatechin gallate 1
Epigallocatechin
Epigallocatechin gallate
Epinephrine
Erythritol
Erythritol
Erythritol
2meso-Erythritol
D-Ethionine
L-Ethionine
Ethyl alcohol
Ethyl alcohol
Ethyl alcohol
Ethylene glycol
3Ethylene glycol
Ferritin
Filipin
Fluoride ion
Fluoride ion
Formic acid
Formic acid4
Formic acid
Fructose
Fructose
Fructose
Fructose
Fructose
Fructose5Fructose
Fructose
Fructose
Fructose
Fructose
Fructose
Fructose6
Fructose
Fructose
Fructo-oligosaccharide
FucoseGalactose
Galactose
Galactose
7
Galactose
Galactose
GallocatechinGDP
Gentiobiose
Gentiobiose
Geraniol
8
Ghrelin human
Ghrelin rat
Gluconic acid
Gluconic acid
Gluconic acid
GlucoseGlucose9
GlucoseGlucoseGlucoseGlucoseGlucoseGlucoseGlucoseIon chromatography
columns and materials

Ion chromatography
columns and materials

3

126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

1

Compound

1070

Figure1

2
Ion chromatography
columns and materials

Ion chromatography
columns and materials

3
Bioseparation columns
and materials

Bioseparation columns
and materials

4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6
SPE sorbent series

SPE sorbent series

SPE sorbent series

7
MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9Compounds index

Compounds index

Compounds index

19
22
19
22
40
17
55
55
56
56
11
24
18
41
32
46
26
26
26
27
27
26
26
55
55
55
55
41
15
15
15
15
16
16
16
18
37
32
11
32
32
32
50
50
39
17
18
55
55
55
55
56
56
26
18
47
47
24
24
24
24
25
41
40
40

Ion exchange columns
and materials

Ion exchange columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

2-38
2-45
2-38 1
2-45
5-12
2-32
6-3
6-3
6-14
2
6-14
2-15
3-2
2-36
5-16
4-6
5-26
3
3-11
3-12
3-13
3-14
3-16
3-11
3-12
4
6-3
6-3
6-3
6-3
5-17
2-21
2-22
5
2-23
2-24
2-25
2-26
2-27
2-37
5-6 6
4-6
2-13
4-5
4-5
4-5
5-35
5-35 7
5-10
2-32
2-37
6-2
6-2
6-9
6-9 8
6-13
6-13
3-11
2-35
5-29
5-30
3-1 9
3-3
3-4
3-5
3-10
5-16
5-14
5-14 10Page

Column selection
guideColumn selection
guideBioseparation columns
and materials

10

CA08F
CDR10
CA08F 1
CDR10
CMG20/C04
CK10U
CRS10W
CRS10W
CRS10W
2
CRS10W
CK08EH
SCK01
CK10U
CHP20/C10
CQP30
CMG20/C10
3
SCA04
SCA04
SCA04
SCA04
SCA04
SCA04
SCA04
4
CRS10W
CRS10W
CRS10W
CRS10W
CHP20/C10
CK04S
CK04SS5CK02A
CK02AS
CK04S
CK04SSCK02AS
CK10U
CHP20/C04
6CQP30
CK08EH
CQP30
CQP30
CQP30
CHP50/P20
CHP50/P20
7
CMG20/C04
CK10U
CK10U
CRS10W
CRS10W
CRS10W
CRS10W
8
CRS10W
CRS10W
SCA04
CK10U
CHP07/C04
CHP20/C04
SCK01 9
SCK01
SCK01
SCK01
CHK45/C05
CHP20/C10
CMG20/C04
10
CMG20/C04

Ion chromatography
columns and materials

9

MCI GEL™ column

Ion exchange columns
and materials

8

Compounds index

Compounds index

10

7

MCI GEL™ material list

MCI GEL™ material list

96

MCI GEL™ column list

MCI GEL™ column list

85SPE sorbent series

SPE sorbent series

74Chiral separation
columns

Chiral separation
columns6

3

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

2

Bioseparation columns
and materials

Bioseparation columns
and materials

4

1

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

Sugar
Sugar
Disaccharide
Disaccharide
PeptideAmino acid
D-Amino acid
L-Amino acid
D-Amino acid
L-Amino acid
Alcohol
Amine
Amino acid
Medicine
Protein
Perfume
Anion
Anion
Anion
Anion
Anion
Anion
Anion
D-Amino acid
L-Amino acid
D-Amino acid
L-Amino acid
Antibiotic
Dp1-Dp9
Dp1-Dp13
Dp1-Dp16
Dp1-Dp20
Dp1-Dp7
Dp1-Dp7
Dp1-Dp7
Amino acid
Carboxylic acid
Protein
Carboxylic acid
PEG
PEG
PEG
Antibiotic
Antibiotic
Medicine
Amino acid
Amino acid
D-Amino acid
L-Amino acid
D-Amino acid
L-Amino acid
D-Amino acid
L-Amino acidAnion
Amino acid
Polyphenol
Polyphenol
CationCationCationCationCationMedicine
Anesthetic
Anesthetic

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Classification

Column selection
guide

1

Column selection
guideColumn selection
guideCompounds index

Compounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

MannoseMannose1
Melibiose
Melibiose
Met-Enkephalin
Methionine
D-Methionine
L-Methionine
D-Methionine
2
L-Methionine
Methyl alcohol
Methylamine
γ-methyl leuicine
Mevastatin
Myoglobin
Nerol
3
Nitrate ion
Nitrate ion
Nitrate ion
Nitrate ion
Nitrate ion
Nitrate ion
Nitrate ion
4
D-Norleucine
L-Norleucine
D-Norvaline
L-Norvaline
Nystatin
Oligosaccharide
Oligosaccharide
5
Oligosaccharide
Oligosaccharide
Oligosaccharide
Oligosaccharide
Oligosaccharide
Ornithine
Orotic acid6
Ovalbumin
Oxalic acid
PEG MW 145,000
PEG MW 40,000
PEG MW 6,000
Penicillin G
Penicillin
7V
Phenacetin
Phenylalanine
Phenylalanine
D-Phenylalanine
L-Phenylalanine
D-Phenylalanine
L-Phenylalanine
8D-α-Phenylglycine
L-α-Phenylglycine
Phosphate ion
Pipecolic acid
Polyphenon 60
Polyphenon 60
Potassium
9 ion
Potassium ion
Potassium ion
Potassium ion
Potassium ion
Pravastatin Na
Procainamide
10
Procaine
Bioseparation columns
and materials

Bioseparation columns
and materials

Bioseparation columns
and materials

4

321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385

Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

CompoundIon exchange columns
and materials

2

Column selection
guide1
Ion exchange columns
and materials

Ion chromatography
columns and materials

Compounds index

Compounds index

54
11
1 30
11
19
20
20
55
55
2 57
57
58
58
42
7
7
3 12
19
22
9
7
12
4 17
18
18
55
55
40
44
5 44
44
44
44
44
46
46
6 46
24
25
47
17
18
55
7 55
25
25
25
11
19
20
8 11
19
19
22
10
10
57
9 57
25
7
8
9
9
7
10 9

Column selection
guide

Page

Ion exchange columns
and materials

MCI GEL™ material list

MCI GEL™ material list

分離例化合物リスト

10

MCI GEL™ column list

MCI GEL™ column list

MCI GEL充 填 剤一覧9

SPE sorbent series

SPE sorbent series

MCI GEL
カラム一覧

8

Chiral separation
columns

Chiral separation
columns

固相吸着剤

7

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

ア ミ ノ酸 D L 分 離 用
充填カラム

6

6-1
2-15
4-3
2-13
2-39
2-41
2-42
6-11
6-11
6-17
6-17
6-22
6-22
5-18
2-1
2-3
2-19
2-38
2-45
2-10
2-3
2-19
2-32
2-36
2-36
6-2
6-2
5-12
5-22
5-22
5-22
5-22
5-22
5-22
5-26
5-27
5-26
3-1
3-10
5-28
2-32
2-37
6-8
6-8
3-7
3-9
3-10
2-13
2-39
2-41
2-13
2-39
2-38
2-45
2-12
2-12
6-18
6-18
3-8
2-1
2-8
2-9
2-10
2-1
2-10

Bioseparation columns
and materials

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

5

及び充填剤

4

CRS10W
CK08EH1
DA01
CK08EH
CA08F
CA08F
CA08F
CRS10W
CRS10W
2
CRS10W
CRS10W
CRS10W/CRS15W
CRS10W/CRS15W
CMG20/C10
CK08ECCK08EC3
CK06SCCA08F
CDR10
CK08ECCK08ECCK06SC
CK10U
4
CK10U
CK10U
CRS10W
CRS10W
CMG20/C04
CHP20/C10
CMG20/C10
5
CHP20/C10
CMG20/C10
CHP20/C10
CMG20/C10
CMG20/C10
CMG20/C10
CMG20/C106SCK01
CHK45/C05
CHK40/C04
CK10U
CK10U
CRS10W
CRS10W
7
SCK01
SCK01
CHK45/C05
CK08EH
CA08F
CA08F
CK08EH
8
CA08F
CA08F
CDR10
CK08E
CK08E
CRS10W
CRS10W9SCK01
CK08ECCK08ECCK08ECCK08ECCK08EC10CK08ECIon chromatography
columns and materials

Ion chromatography
columns and materials

生体高分子分離用
充填カラム及び充填剤

3FigureIon exchange columns
and materials

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

2

MCI GEL™ column

Column selection
guide

1

Column selection
guideColumn selection
guideClassification

L-Amino acid1
Alcohol
EnzymeCarboxylic acid
Carboxylic acid
Carboxylic acid
Carboxylic acidD-α-Hydroxycarboxylic acid2
L-α-Hydroxycarboxylicacid
D-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acidD-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acid
Protein
Disaccharide
3
Disaccharide
Disaccharide
Disaccharide
Disaccharide
Disaccharide
Disaccharide
4
Disaccharide
Amino acid
Amino acid
Amino acid
D-Amino acid
L-Amino acid
Peptide5
PeptidePeptidePeptidePeptidePeptidePeptide6
Perfume
Perfume
PerfumeCationCationSartan7Amino acid
Amino acid
D-Amino acid
L-Amino acid
CationCationCationCarboxylic acid
Carboxylic acid
Carboxylic acid
Carboxylic acid
Carboxylic acid
9
Disaccharide
Disaccharide
Disaccharide
Disaccharide
D-α-Hydroxycarboxylic acid
L-α-Hydroxycarboxylic acid10
CationSugar alcohol
Sugar alcohol
Sugar alcohol
Sugar alcohol
Sugar
11
Sugar
イオン交換クロマトグラフィー用
充填カラム及び充填剤

71

カラム選択の手引き

Compounds index

10Compounds index

MCI GEL™ material list

9

MCI GEL™ material list

MCI GEL™ column list

8

MCI GEL™ column list

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4allo-L-Isoleucine
Isopropyl alcohol
1KinaseLactic acid
Lactic acid
Lactic acid
Lactic acid
D-Lactic acid
L-Lactic acid2
D-Lactic acid
L-Lactic acid
D-Lactic acid
L-Lactic acid
β-Lactoglobulin
LactoseLactose3
LactoseLactoseLactoseLactose monohydrate
Lactulose
Lactulose
Leucine4
Leucine
Nor-Leucine
D-Leucine
L-Leucine
Leu-Enkephalin
Leuprorelin
Leuprorelin
5
LH-RH human
LH-RH human
LH-RH salmon
LH-RH salmon
Linalool
Linalool
Linalyl acetate
6
Lithium ion
Lithium ion
Losartan
LysineLysineD-Lysine
L-Lysine
7
Magnesium ion
Magnesium ion
Magnesium ion
Malic acid
Malic acid
Malic acidMalonic acid8
Malonic acid
MaltoseMaltoseMaltoseMaltotriose
D-Mandelic acid
L-Mandelic acid
9
Manganese ion
MannitolMannitolMannitolMannitol
MannoseMannoseIon chromatography
columns and materials

Ion chromatography
columns and materials

3

256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

1

Compound

1072

Figure1

2
Ion chromatography
columns and materials

Ion chromatography
columns and materials

3
Bioseparation columns
and materials

Bioseparation columns
and materials

4
Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6
SPE sorbent series

SPE sorbent series

SPE sorbent series

7
MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9Compounds index

Compounds index

Compounds index

27
27
17
45
48
21
45
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
53
21
42
12
12
24
48
48
36
55
55
17
18
55
55
21
21
48
21
45
48
37
24
45
48
22
37
17
18
18
55

Ion exchange columns
and materials

Ion exchange columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

3-15
3-15
2-32 1
5-25
5-33
2-43
5-25
5-41
5-41
2
5-41
5-42
5-42
5-42
5-43
5-43
5-43
3
5-43
5-44
5-44
5-44
5-44
5-41
5-41
4
5-41
5-41
5-42
5-43
5-43
5-43
5-43
5
5-44
5-44
5-44
5-44
5-41
2-43
5-18 6
2-16
2-17
3-2
5-31
5-32
5-2
6-10 7
6-10
2-32
2-37
6-2
6-2
2-44
2-44 8
5-33
2-43
5-25
5-33
5-6
3-6
5-259
5-33
2-46
5-7
2-32
2-33
2-36
6-2 10Page

Column selection
guideColumn selection
guideBioseparation columns
and materials

10

SCA04
SCA04
CK10U 1
CHK40/C04
CHK45/C05
CDR10
CHK40/C04
CMG20/C04
CMG20/C04
2
CMG20/C04
CMG20/P30
CMG20/P30
CMG20/P30
CMG20/C04
CMG20/C04
CMG20/C04
3
CMG20/C04
CMG20/P150
CMG20/P150
CMG20/P150
CMG20/P150
CMG20/C10
CMG20/C10
4
CMG20/C10
CMG20/C04
CMG20/P30
CMG20/C04
CMG20/C04
CMG20/C04
CMG20/C04
5
CMG20/P150
CMG20/P150
CMG20/P150
CMG20/P150
CMG20/C10
CDR10
CMG20/C10
6CK08EH
CK08EHSCK01
CHPOD/04
ODS-1HU
CHP20/C04
CRS10W7
CRS10W
CK10U
CK10U
CRS10W
CRS10W
CDR10
CDR10 8
CHK45/C05
CDR10
CHK40/C04
CHK45/C05
CHP20/C04
SCK01
CHK40/C04
9
CHK45/C05
CDR10
CHP20/C04
CK10U
CK10U
CK10U
CRS10W10
Ion chromatography
columns and materials

9

MCI GEL™ column

Ion exchange columns
and materials

8

Column selection
guide

7

Compounds index

Compounds index

10

6

MCI GEL™ material list

MCI GEL™ material list

95

MCI GEL™ column list

MCI GEL™ column list

84SPE sorbent series

SPE sorbent series

73Chiral separation
columns

Chiral separation
columns62

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

1

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Anion
Anion
Amino acid
Nucleoside
Nucleoside
Nucleic base
Nucleic baseVitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Vitamin
Nucleotide
Protein
Carboxylic acid
Polyalcohol
Amine
Surfactant
Surfactant
Amino acid
D-Amino acid
L-Amino acid
Amino acid
Amino acid
D-Amino acid
L-Amino acid
Nucleotide
Nucleotide
Nucleotide
Nucleic base
Nucleic base
Nucleic base
2,6,8-Trioxypurine
Nucleoside
Nucleoside
Nucleoside
Urine
Bile acid
Amino acid
Amino acid
Amino acid
D-Amino acidIon chromatography
columns and materials

Ion chromatography
columns and materials

3

Classification

Ion exchange columns
and materials

2

Column selection
guide1
Ion exchange columns
and materials

Compounds index

Compounds index

Compounds index

10

MCI GEL™ material list

MCI GEL™ material list

MCI GEL™ material list

9

MCI GEL™ column list

MCI GEL™ column list

MCI GEL™ column list

8

SPE sorbent series

SPE sorbent series

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

Thiocyanic ion
Thiosulfuric ion
1
ThreonineThymidine
Thymidine
ThymineThymineD-α-Tocopherol
D-γ-Tocopherol
2
D-δ-Tocopherol
D-α-Tocopherol
D-γ-Tocopherol
D-δ-Tocopherol
D-α-Tocopherol
D-β-Tocopherol
D-γ-Tocopherol
3
D-δ-Tocopherol
D-α-Tocopherol
D-β-Tocopherol
D-γ-Tocopherol
D-δ-Tocopherol
D-α-Tocopherol
D-γ-Tocopherol
4
D-δ-Tocopherol
D-γ-Tocotrienol
D-γ-Tocotrienol
D-α-Tocotrienol
D-β-Tocotrienol
D-γ-Tocotrienol
D-δ-Tocotrienol
5D-α-Tocotrienol
D-β-Tocotrienol
D-γ-Tocotrienol
D-δ-Tocotrienol
D-γ-Tocotrienol
TPN
Transferrin
6
Trichloroacetic acid
Triethylene glycol
Trimethylamine
TritonX-100
TritonX-100
Tryptophan
D-Tryptophan
7
L-Tryptophan
Tyrosine
Tyrosine
D-Tyrosine
L-Tyrosine
3'-UMP
5'-UMP8
UMP
UracilUracilUracilUric acid
UridineUridine9
UridineUrine
Ursodeoxycholic acid
ValineValineValine10
D-Valine
Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515

Ion exchange columns
and materials

Ion exchange columns
and materials

2

CompoundColumn selection
guide

1

Column selection
guideColumn selection
guideAnalytical and preparative
chromatography columns and materials
for pharmaceutical applications

Compounds index

Compounds index

10

17
18
1 55
55
11
20
36
19
22
2 9
40
42
42
7
9
19
3 22
30
24
7
9
51
4 51
51
51
51
51
51
17
5 55
55
36
44
41
24
24
6 24
24
25
7
45
7
9
7 25
25
20
39
7
8
8
8 10
16
26
26
26
39
39
9 39
11
19
20
18
36
36
1037
Bioseparation columns
and materials

9

2-32
2-35
6-2
6-2
2-15
2-41
5-5
2-38
2-45
2-10
5-13
5-18
5-19
2-1
2-10
2-38
2-45
4-1
3-1
2-1
2-10
5-37
5-37
5-37
5-37
5-37
5-37
5-38
2-32
6-4
6-4
5-2
5-23
5-16
3-1
3-3
3-4
3-5
3-10
2-2
5-24
2-1
2-10
3-7
3-8
2-41
5-11
2-2
2-4
2-5
2-11
2-30
3-11
3-12
3-13
5-11
5-11
5-11
2-13
2-39
2-41
2-36
5-4
5-4
5-6

Page

Ion chromatography
columns and materials

8

FigureIon exchange columns
and materials

7

MCI GEL™ material list

MCI GEL™ material list

分離例化合物リスト

10

6

MCI GEL™ column list

MCI GEL™ column list

MCI GEL充 填 剤一覧95

SPE sorbent series

SPE sorbent series

MCI GEL
カラム一覧

8

4

Chiral separation
columns

Chiral separation
columns

固相吸着剤

7

3

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

ア ミ ノ酸 D L 分 離 用
充填カラム

6

2

Bioseparation columns
and materials

Bioseparation columns
and materials

医 薬 精 密 精 製 用 充 填 カ ラム

5

及び充填剤

4

1

Ion chromatography
columns and materials

Ion chromatography
columns and materials

生体高分子分離用
充填カラム及び充填剤

3

CK10U
CK10U
CRS10W
CRS10W
CK08EH
CA08F
CHP20/C04
CA08F
CDR10
CK08EC
CMG20/C04
CMG20/C10
CHP20/C10
CK08ECCK08EC
CA08F
CDR10
SP01
SCK01
CK08ECCK08ECCHP20/C10
CHP20/C10
CHP20/P20
CHP20/P20
CHP20/P30
CHP20/P30
CHP20/P30
CK10U
CRS10W
CRS10W
CHP20/C04
CMG20/C10
CHP20/C10
SCK01
SCK01
SCK01
SCK01
CHK45/C05
CK08ECCHP20/C10
CK08ECCK08EC
SCK01
SCK01
CA08F
CMG20/C04
CK08ECCK08ECCK08ECCK08EC
CK04S
SCA04
SCA04
SCA04
CMG20/C04
CMG20/C04
CMG20/C04
CK08EH
CA08F
CA08F
CK10U
CHP20/C04
CHP20/C04
CHP20/C04

Ion exchange columns
and materials

Ion exchange columns
and materials

イオンクロマトグラフィー用
充填カラム及び充填剤

2

MCI GEL™ column

Column selection
guide

1

Column selection
guideColumn selection
guideClassification

Amino acid
1 acidAmino
D-Amino acid
L-Amino acid
Alcohol
Carboxylic acid
Cinchona alkaloid
Sugar
2
Sugar
Sugar alcohol
ProteinProteinProtein
Sugar
Sugar
3
Sugar
Sugar
Monoclonal antibody
CationPhenol glycoside
Phenol glycoside
4
SennosideA
Sennoside B
Sennoside A
Sennoside B
Sennoside A
Sennoside B
Sennoside A
5 acidAmino
D-Amino acid
L-Amino acid
Catecholamine
PeptideMedicine
6
CationCationCationCationCationSugar alcohol
7RNA
Tetrasaccharide
Sugar
CationCationCarboxylic acidSulfa drug
Disaccharide
Disaccharide
Disaccharide
Disaccharide
Disaccharide
9
Anion
Anion
Anion
Sulfa drug
Sulfa drug
Sulfa drug
10
Carboxylic
acid
Carboxylic acid
Carboxylic acid
Amino acid
Purine alkaloid
Purine alkaloid
11 alkaloid
Purine
イオン交換クロマトグラフィー用
充填カラム及び充填剤

73

カラム選択の手引き

Compounds index

10Compounds index

MCI GEL™ material list

9

MCI GEL™ material list

MCI GEL™ column list

8

MCI GEL™ column list

SPE sorbent series

7

Chiral separation
columns

Chiral separation
columns

6

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

5

Bioseparation columns
and materials

Bioseparation columns
and materials

4

ProlineProline1
D-Proline
L-Proline
n-Propyl alcohol
Pyruvic acid
QuinineRhamnoseRhamnose2
Ribitole(Adnitole)
Ribonuclease A
Ribonuclease A
Ribonuclease A
RiboseRiboseRibose3
RiboseRituximab
Rubidium ion
Salicin
SalicinSennoside A
Sennoside B
4
Sennoside A
Sennoside B
Sennoside A
Sennoside B
Sennoside A
Serine
D-Serine
5
L-Serine
Serotonin
Sifuvirtide
Simvastatin
Sodium ion
Sodium ion
Sodium ion
6
Sodium ion
Sodium ion
SorbitolssRNA
Stachyose
Stachyose hydrate
Strontium ion
7Strontium ion
Succinic acid
Succinylsulfathiazole
SucroseSucroseSucroseSucrose8
SucroseSulfate ion
Sulfate ion
Sulfate ion
Sulfamerazine
Sulfanilamide
Sulfathiazole
9
Tartaric acid
Tartaric acid
Tartaric acid
Tert-leuicine
Theobromine
Theophylline
Theophylline
Ion chromatography
columns and materials

Ion chromatography
columns and materials

3

386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

1

Compound1074

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications
MCI GEL™ column list

MCI GEL™ column
CRS10W
CHK40/C04
CMG20/C04
CMG20/C04
CMG20/C04
CMG20/C04
CHP20/C04
CHK40/C04
CHK45/C05
CHK45/C05
CHK40/C04
CK08ECCK08EC
CA08F
CDR10
SCK01

Figure

Page

6-2
5-28
5-15
5-15
5-15
5-15
5-6
5-25
5-33
5-33
5-25
2-1
2-10
2-38
2-45
3-7

55
47
40
40
40
40
37
45
48
48
45
7
9
19
22
25

Limited warranty

Mitsubishi Chemical Corporation warrants that its pre-packed columns (including separation media
products) shall meet published specifications at the time of shipment from Mitsubishi Chemical
Corporation. Because of the susceptibility of these products to deterioration, all warranty claims
must be made within the stipulated in the listed sales office. All claims shall be deemed waived in
the event the purchaser fails to notify the company within the period.

Conditions

A. The products in this brochure are for laboratory or manufacturing use. They are not intended for drug,
medicine, food additive or household use. Compliance with local and government regulations
concerning their use is the responsibility of the purchaser.
B. Voiding of warranty :This warranty is null and void if any product has been (1) altered or modified such that its stability or
reliability is any way affected ; (2) misused ; or (3) damaged by abuse, negligence or accident.
The term "misuse" includes, but is not limited to, use not in compliance with the "Column
Handling Instructions".
C. Limitations and Exclusions :All recommendations, information and descriptions supplied by Mitsubishi Chemical Corporation
with respect to any product in this brochure are believed to be accurate and reliable, but do notconstitute warranties. The sole liability of Mitsubishi Chemical Corporation for any breach of
warranty is limited to replacement, or at the sole option of Mitsubishi Chemical Corporation arefound of the purchase price.

Changes

All specifications, quantities, designs and prices are subject to change without notice.

GeneralNeither this publication, nor any products in this brochure shall be construed as recommending theinfringement of any patent, nor extending any license, express or implied, nor assuming any
liability under any issued or pendinng patent. The data presented herein have been carefullycompiled from our records which we believe to be accurate and reliable. We make, however, nowarranties or representations with respect hereto, nor is freedom from any patent to be inferred.

7

7

8

9

MCI GEL充 填 剤一覧

Compounds index

MCI GEL™ material list

9

MCI GEL
カラム一覧

MCI GEL™ material list

MCI GEL™ column list10
分離例化合物リスト

Compounds index

75

6

固相吸着剤

Chiral separation
columns

SPE sorbent series

10

ア ミ ノ酸 D L 分 離 用
充填カラム

Chiral separation
columns9

医 薬 精 密 精 製 用 充 填 カ ラム

Bioseparation columns
and materials

Analytical and preparative
chromatography columns and materials
for pharmaceutical applications

6

8

5

5

6

7

4

及び充填剤

Bioseparation columns
and materials

4

生体高分子分離用
充填カラム及び充填剤

3

イオンクロマトグラフィー用
充填カラム及び充填剤

2Classification

L-Amino acid1
SartanWater soluble vitamin
Water soluble vitamin
Water soluble vitamin
Water soluble vitamin
2,6-Dihydroxypurine
Nucleic base2
Nucleic
base
Nucleic base
Nucleoside
Sugar alcohol
Sugar alcohol
Sugar
Sugar
3
Cation
イオン交換クロマトグラフィー用
充填カラム及び充填剤

1

4

5

カラム選択の手引き

L-Valine
Valsartan
Vitamin B3
Vitamin B6
Vitamin B12
Vitamin C
Xanthine
Xanthine
Xanthine
Xanthine oxidase
Xanthosine
Xylitol
Xylitol
XyloseXyloseZinc ionIon chromatography
columns and materials

Ion chromatography
columns and materials

3

516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531

Ion exchange columns
and materials

Ion exchange columns
and materials

2

Column selection
guideColumn selection
guide

1

Compound

1176

Dia Related

Ion Exchange Resins（DIAION )TM

Product Lineup

Strongly Acidic Cation Exchange Resins(Gel, Porous, Highly Porous Type and Industrial Chromatography)
DIAION™ SK, UBK, PK series

Weakly Acidic Cation Exchange Resins(Methacrylic and AcrylicType)DIAION™ WK series

Strongly Basic Anion Exchange Resins(Gel, Porous, and Highly Porous Type)DIAION™ SA, UBA, PA, HPA series

D I A I O NSEPABEADES
MabSpeed
ChromSpeed™

™

Weakly Basic Anion Exchange Resins(Acrylic, Polyamine, and Dimethylamine Type)DIAION™ WA series

Chelating Resins（DIAION )TMIminodiacetate type, Polyamine Type, and Glucamine TypeDIAION™ CR series™

™

Synthetic Adsorbents（DIAION /SEPABEADS )TM

Aromatic Type, Modified Aromatic Type, and Methacrylic TypeDIAION™ HP series
SEPABEADES

Bioseparation Media

Affinity Chromatography Resins
MabSpeed™ RP series

Strongly Acidic Cation Exchange Resins
ChromSpeed™ S series

Weakly Acidic Cation Exchange Resins
ChromSpeed™ CM series

Strongly Basic Anion Exchange Resins
ChromSpeed™ Q series

Weakly Basic Anion Exchange Resins
ChromSpeed™ DA series

Screening Columns

MabSpeed™, ChromSpeed™

TM