Kanazawa Medical University
Research Activities and Publications
VOL. 25 2013

Kanazawa Medical University

I
Code

Department

Basic

N
Page

D

E

X

Code

Department

Page

Medicine

0100

Department of Anatomy Ⅰ ····················· 10420

Department of General and Digestive Surgery ···· 65

0110

Department of Anatomy Ⅱ ·························· 20430

Department of Orthopedics Surgery ··············· 68

0120

Department of Physiology Ⅰ ························ 30440

Department of Neurosurgery························· 72

0130 Department of Physiology Ⅱ ························· 50450

Department of Plastic and Reconstructive

0140

Department of Biochemistry Ⅰ ··················· 70150

Department of Biochemistry Ⅱ ··················· 80460

Department of Pediatric Surgery···················· 77

0160

Department of Pharmacology ······················ 90470

Department of Ophthalmology ······················· 79

0170

Department of Pathology Ⅰ ···················· 110475

Department of Otorhinolaryngology ··············· 82

0180

Department of Pathology Ⅱ······················ 120485

Department of Head and Neck Surgery ·········· 84

0190

Department of Microbiology ····················· 140490

Department of Dermatology ·························· 850200

Department of Immunology························ 150500

Department of Urology ·································· 87

0210

Department of Medical Zoology ················· 160510

Department of Obstetrics and Gynecology ······ 890220

Department of Pathology and Laboratory

0520

Department of Anesthesiology andSurgery ····················································· 74

Medicine ················································· 170230

Department of Social and Environmental

Perioperative Medicine ································ 91
0540

Medicine ················································ 19

Department of Physical and Rehabilitation
Medicine ····················································· 930240 Department of Epidemiology and Public Health · 210550

Department of Emergency Medicine ··············· 95

0250

Department of Legal Medicine ·················· 25

0570

Department of Community Medicine ·············· 960260

Department of Medical Education ············· 260575

Department of Gastroenterological Endoscopy ···· 970580

Department of Oral and Maxillofacial Surgery ··· 98

Clinical Medicine
0300

Department of Cardiology ························· 27

0310

Department of Respiratory Medicine ············· 29

0635

Hepatology ················································ 99

0320

Department of Gastroenterology ··············· 310675

Health Evaluation Center ························· 101

0330

Department of Nephrology ························· 35

0340

Department of Diabetology andUniversity

MedicalHospital

Research

Institute

Endocrinology ············································ 38

7100

Department of Life Science ························· 1050350

Department of Hematology and Immunology ·· 427200

Department of Advanced Medicine ··············· 109

0360

Department of Neurology ·························· 45

7310

Division of Innovative Research ····················· 114

0363

Department of Medical Oncology ················ 48

7320

Division of Vision Research for

0366

Department of Infectious Diseases ·············· 50

0368

Department of General Internal Medicine ···· 51

0370

Department of Geriatric Medicine··············· 53

0380

Department of Pediatrics ·························· 55

0390

Department of Neuropsychiatry ················· 57

8010

Fundamental Nursing ································ 1220400

Department of Radiology ····························· 598040

Adult Nursing ··········································· 123

0410

Department of Cardiovascular Surgery ···· 61

8050

Gerontological Nursing ······························· 1240415

Department of Thoracic Surgery ················· 62

8060

Pediatric Nursing ······································ 125

Environmental Health ···················· 117
7330

Division of Dermatomycology ······················· 120

Schoolof

NursingCode

Department

Page

8070

Maternity Nursing・Midwifery ··················· 126

8080

Community Health Nursing ······················· 127

8085

Psychiatric and Mental Health Nursing ······· 128

8090

Home Care Nursing ··································· 129

8095

Comprehensive Nursing ····························· 130

8100

Medical Science········································· 131

Liberal
8510

Arts

Life Science(Natural Science) ····················· 134

8530 Life Science (Physical Education) ····················· 136
8550

Human Science (Humanities) ····················· 137

8570

Human Science (Mathematics) ················· 138

8590

Human Science (Foreign Languages) ·········· 139

AffiliatedInstitution

9030

North Noto Institute of Community Medicine ····· 141

9050

FDD-MB Center ······································ 142

Himi
9100

Municipal

Hospital

Himi Municipal Hospital ···························· 143

CodeDepartment

Page

Basic Medicine

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Associate Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Presentations at Conference
International Conference (Presentations)
0100I001

T.Tsukada, E.Simamura, H.Shimada, T.Akai, H.Iizuka, T.Hatta: Maternal immune activation impairs the maternalfetal leukemia inhibitory factor signal relay and reduces neural stem/progenitor cell proliferation, Neuroscience
2013, (San Diego, California, '13.11).

－ 1 －

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy, embryology, lymphatic vessels, microscopy

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy, central nervous system

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry, pituitary, cell proliferation, electron
microscopy

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA, Neuroanatomy,
FIB/SEM, BMI, gustatory

Outline of Research
Theme of researches
1)Human gross anatomy
2)Neural network of the basal ganglia
3）Circuit of gustatory in the central nervous system
4）Anatomical study of brain white matter by using fiber dissection technique5）Immuno-histochemical study of pituitary gland

Publications
Originals
0110B001

T.Shimokawa, R.Kominami, S.Yasutaka, H.Shinohara: Misexpression experiment of Tbx5 in axolotl (Ambystoma
mexicanum) hindlimb blastema., Okajimas Folia Anat. Jpn., 89:113-118, 2013.

0110B002

T.Shimokawa, S.Yasutaka, R.Kominami, H.Shinohara: Lmx-1b and Wnt-7a expression in axolotl limb during
development and regeneration., Okajimas Folia Anat. Jpn., 89:119-124, 2013.

0110B003

S.Yasutaka, H.Shinohara, R.Kominami: Gross anatomical tractography (GAT) proposed a change from the 'Twolaminae concept' to the 'Neuronal unit concept' on the structure of the human hippocampus., Okajimas Folia Anat.
Jpn., 89:147-156, 2013.

0110B004

R.Kominami, H.Shinohara, S.Yasutaka, M.Kishibe: The human hippocampus observed by scanning electron
microscopy (SEM): The dentate gyrus is made of an array of the neuronal lamellae., Okajimas Folia Anat. Jpn.,
89:157-164, 2013.

－ 2 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Associate Professor

SUGAI Tokio

Neurophysiology

Assistant Professor

TAJIMA Nobuyoshi

molecular physiology

Assistant Professor

YAMAMOTO Ryo

Neuroscience

Researcher

SUI GenAnalysis of Alzheimer disease model mice in search for new
therapeutic approaches

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001

Z-D Wang, L Wang, R.Yamamoto, T.Sugai, N.Kato: Role of the lateral habenula in shaping context-dependent
locomotor activity during cognitive tasks., Neuroreport., 24:276-280, 2013.

0120B002

H.Yoshimura, T.Sugai, T.Hasegawa, C.Yao, T.Akamatsu, N.Kato: Age-dependent emergence of caffeine-assisted
voltage oscillations in the endopiriform nucleus of rats., Neurosci. Res., 76:16-21, 2013.

0120B003

T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino: Cardiac
BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., The
Internet Journal of Cardiovascular Research., 8, 2013.

－ 3 －Presentations at Conference
International Conference (Presentations)
0120I001

K.Tanaka, M.Fujita, Y.Ishigaki, N.Kato, M.Matsui, M.Tanaka, T.Takegami: Effects of the CSF from anti-NMDA
receptor encephalitis patient on the cultured neurons, The American Academy of Neurology's 65th the ANN
Annual Meeting, (SanDiego, '13.03).

0120I002

Y.Shui, R.Yamamoto, N.Kato: Involvement of homer1a in resilience to chronic mild stress., Neuroscience 2013 Society for Neuroscience-, (San Diego, '13.11).

0120I003

R.Yamamoto, T.Sugai, N.Kato: Serotonergic modulation on resting membrane potential of lateral amygdala neuron.,
Neuroscience 2013 -Society for Neuroscience-, (San Diego, '13.11).

－ 4 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

TANIDA Mamoru

Circulatory Physiology

Researcher

YAMAMOTO Yuki

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

S.Shinomiya, T.Shibamoto, Y.Kurata, Y.Kuda, W..Zhang, M.Tanida, H.Toga: Nitric oxide and β2-adrenoceptor
activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice.,Exp. Lung Res., 39:119-129, 2013.

0130B002

M.Tanida, N.Yamamoto, T.Shibamoto, K.Rahmouni: Involvement of hypothalamic AMP-activated protein kinase inleptin-induced sympathetic nerve activation., PLoS ONE, 8:e56660;1-11, 2013.

0130B003

Y.Kurata, I.Hisatome, M.Tanida, T.Shibamoto: Effect of hyperpolarization-activated current I(f) on robustness ofsinoatrial node pacemaking: theoretical study on influence of intracellular Na(+) concentration., Am. J. Physiol.
Heart Circ. Physiol., 304:H1337-H1351, 2013.

0130B004

M.Kitadate, T.Shibamoto, M.Tsutsumi, H.Tonami: Portal venular constriction during anaphylactic shock inanesthetized rats., Biomed. Res., 34:61-68, 2013.

0130B005

M.Wang, M.Tanida, T.Shibamoto, Y.Kurata: Alpha-adrenoceptor antagonists and chemical sympathectomy
exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats., Am. J. Physiol.
Regul. Integr. Comp. Physiol., 305:R900-:R907, 2013.

－ 5 －0130B006(H.Cui), Y.Okamoto, K.Yoshioka, W.Du, N.Takuwa, W.Zhang, M.Asano, T.Shibamoto, Y.Takuwa: Sphingosine-1phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthasein mice., J Allergy Clin Immunol, 132:1205-1214, 2013.

0130B007

I.Toyota, M.Tanida, T.Shibamoto, Mofei Wang, Y.Kurata, H.Tonami: MRI Reveals edema in larynx (But not inbrain) during anaphylactic hypotension in anesthetized rats., Allergy Asthma Immunol Res., 5:389-396, 2013.

0130B008

W.Zhang, T.Shibamoto, M.Tanida, M.Wang, L.Sun, Y.Kurata: Rat hepatic and splanchnic vascular responses toanaphylactic shock, compared with hemorrhagic or vasodilator-induced shock., In Vivo., 27:485-494, 2013.

0130B009

M.Tanida, A.Hayata, N.Shintani, N.Yamamoto, Y.Kurata, T.Shibamoto, D.A.Morgan, Rahmouni K, H.Hashimoto:Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner., Neuroscience, 238:297304., 2013.

0130B010(C.Iwai), P.Li, Y.Kurata, Y.Hoshikawa, K.Morikawa, N.Maharani, K.Higaki, T.Sasano, T.Notsu, Y.Ishido, J.Miake,
Yamamoto Y, Y.Shirayoshi, H.Ninomiya, A.Nakai, S.Murata, A.Yoshida, K.Yamamoto, M.Hiraoka, I.Hisatome:
Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant
HERG proteins., Cardiovasc. Res., 100:520-528, 2013.

Presentations at Conference
International Conference (Synposium)
0130H001

Y.Kurata, I.Hisatome, M.Tanida, T.Shibamoto: Dynamical Mechanisms of Phase 2 Early Afterdepolarizations inLong QT Syndromes: Insights from bifurcation analyses of a mathematical model for human ventricular myocytes,
The 2nd HD Physiology International Symposium: Multi-Level Systems Biology, (Tokyo, '13.06)，The 2nd HD
Physiology International Symposium Abstract Book, p.67.

International Conference (Presentations)
0130I001

T.Shibamoto, Y.Yamamoto, Y.Kuda, M.Tanida, M.Wang, Y.Kurata: Effect of exercise training on ischemiareperfusion injury of steatotic livers from OLETF rats, Experimental Biology 2013, (Boston (USA), '13.04)，
EB2013 Meeting program, P202.

0130I002

T.Shibamoto, M.Tanida, M.Wang, Y.Kurata: Exercise attenuates ischemia-reperfusion injury of nonalcoholic fatty
liver of the OLETF rat., The 37th Congress of the International Unions of Physiological Sciences,, (Birmingham,'13.07)，IUPS 2013 programme, P116, 2013.

0130I003

M.Tanida, T.Shibamoto, K.Rahmouni: Hypothalamic AMP-Activated protein kinase is implicated in leptin-induced
sympathetic nerve activation, The 37th Congress of the International Unions of Physiological Sciences,(Birmingham, '13.07)，IUPS 2013 programme :, P48, 2013.

－ 6 －

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SUNATANI Yumi

Function of DNA double-strand break proteins

Assistant Professor

SAKASAI Ryo

DNA damage response induced by anti-cancer drugs

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

M.Doai, N.Watanabe, T.Takahashi, M.Taniguchi, H.Tonami, K.Iwabuchi, D.Kayano, M.Fukuoka, S.Kinuya:
Sensitive immunodetection of radiotoxicity after iodine-131therapy for thyroid cancer using γ-H2AX foci of
DNA damage in lymphocytes., Ann. Nucl. Med., 27:233-238, 2013.

0140B002

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

0140B003(A.Kurosawa), S.Saito, S.So, M.Hashimoto, K.Iwabuchi, H.Watabe, N.Adachi: DNA ligase IV and artemis act
cooperatively to suppress homologous recombination in human cells: Implications for DNA double-strand breakrepair., PLoS ONE, 8:e72253;1-11, 2013.

－ 7 －

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate Professor

YOSHITAKE Yoshino

MicroRNA involved in angiogenesis, Functions of FGF-2 binding
proteinSenior Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Faculty

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001(A.Takeuchi), Y.Yamamoto, S.Munesue, A.Harashima, T.Watanabe, H.Yonekura, H.Yamamoto, H.Tsuchiya: Low
molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression ofmalignant phenotype in human fibrosarcoma cells., Cancer Sci., 104:740-749, 2013.

0150B002(S.Munesue), Y.Yamamoto, R.Urushihara, K.Inomata, H.Saito, S.Motoyoshi, T.Watanabe, H.Yonekura,
H.Yamamoto: Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of
RAGE trafficking to lipid rafts., Food Funct., 4:1835-1842, 2013.

－ 8 －

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor(Additional Post)

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Senior Assistant Professor

MASUOKA Takayoshi

Researcher

IMAIZUMI Noriko

Researcher

KUDO Makiko

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemPharmacology in cardiovascular system, Cancer chemotherapy
Electrophysiology and behavioural pharmacology in central andperiphenal nervous system
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy
Electrophysiology and behavioural pharmacology in central andperiphenal nervous system

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitricoxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation,
cell biology, hippocampal synopes, muscarinic acetylcholine receptor, peripheral sensory neuron, metabotropic glutamate
receptor

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system
６ Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation

Publications
Originals
0160B001

T.Ishibashi, M.Nomura-Nakamoto, F.Abe, T.Masuoka, N.Imaizumi, J.Yoshida, Tomie Kawada, M.Nishio: Effects ofcyanamide, an aldehyde dehydrogenase type2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced
vasodilation in rabbit excised aorta and in anesthetized whole animal., Biol.Pharm.Bull., 36:556-563, 2013.

0160B002(AS.Anisuzzaman), J.Uwada, T.Masuoka, Y.Hatsumi, M.Nishio, Y.Ikegaya, N.Takahashi, N.Matsuki, Y.Fujibayashi,
Y.Yonekura, T.Momiyama, I.Muramatsu: Novel contribution of cell surface and intracellular M1-muscarinic
acetylcholine receptors to synaptic plasticity in hippocampus., J. Neurochem., 126:360-371, 2013.

Reviews
0160C001

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

－ 9 －0160C002

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

Presentations at Conference
International Conference (Presentations)
0160I001

T.Masuoka, T.Nakamura, J.Yoshida, Y.Takaoka, N.Imaizumi, T.Ishibashi, M.Nishio: Modulation of TRPV1 andvoltage-gated calcium channels by peripheral metabotropic glutamate receptors type 5 contributes to heat hyperand hypoalgesia in mice., Society for Neuroscience 2013, (San Diego, '13.11).

－ 10 －

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Assistant Professor

YOSHIZAKI Hisayoshi Molecular and Cellular Biology，Fluorescent Imaging

Researcher

NISHIHAMA Harumi

Molecular and Cellular Biology

Researcher

HARUTA Yui

Molecular and Cellular Biology

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin

Outline of Research
Based on the principal of FRET, we generate biosensors to investigate cell signalling pathways. We also develop the system
to manipulate cell signalling to understand the molecular mechanisms for cancer development and morphology.

Presentations at Conference
International Conference (Presentations)
0170I001

E.Kubo, N.Hasanova, H.Osada, E.Kiyokawa, H.Sasaki, F.Nigar, S.Dhirendra: FGF2 Antagonizes the TGFβ2induced aberrant expression of tropomuosin and α-smooth muscle actin in mouse and human lens epithelial cells
and has a role in posterior capsule opacity, The Association for Research in Vision and Ophthalmology, (Seattle,'13.05).

0170I002

E.Kiyokawa: Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure
maintenance., 1st International Meeting for Epithelial Tubulology, (Sapporo, '13.06).

－ 11 －

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Neuropathology

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

K.Usuda, Xi.Zhao, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma:
Diffusion-weighted imaging(DWI)signal intensity and distribution represent the amount of cancer cells and theirdistribution in primary lung cancer., Clin. Imaging, 37:265-272, 2013.

0180B002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantage of diffusion-weighted imaging over positron emission tomography-computed in assessment ofhilar and mediastinal lymph node in lung cancer., Ann. Surg. Oncol., 20:1676-1683, 2013.

0180B003

S. Nishiike, T. Hiramatsu, M. Shiraishi, Y. Ueda, H. Tsuchida: Relationship between vascular reactivity andexpression of HMGB1 in a rat model of septic aorta., J. Anesth., 27:684-692, 2013.

Case Reports
0180D001

I.Chikazawa, D.Nakai, K.Miyazawa, T.Tanaka, K.Suzuki, K.Sato, Y.Motoo: Neuroendcrine carcinoma of theprostate treated combined modality therapy., Jpn. J. Cancer Clin., 59：99-104, 2013 (in Japanese) .

0180D002(D.Saito), M.Oda, T.Yamato, T.Imai, Y.Tatsuzawa, K.Sato: Rapidly growing mediastinal dedifferentiatedliposarcoma., Proceedings of the Japanese Lung Cancer Society Lung cancer., 53:767-770, 2013 (in Japanese) .

－ 12 －

Presentations at Conference
International Conference (Presentations)
0180I001

Y.Ikawa, M.Yagishita, Y.Himi, N.Koizumi, S.Kawakami, M.Shimasaki, Y.Ueda: Proliferation and induced
differentiation of auricular perichondrium cell., The 22th China-Japan Joint Meeting on Plastic Surgery, (China,'13.08).

0180I002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography inassessment of hilar and mediastinal lymph node in lung cancer, 18th world cangress on advances in oncology,(Athens, '13.10).

－ 13 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology, Neuroimmunology

Professor

MURAKI Yasushi

Virology

Senior Assistant Professor

HIMEDA Toshiki

Neurovirology

Assistant Professor

OKUWA Takako

Virology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

T.Himeda, T.Hosomi, T.Okuwa, Y.Muraki, Y.Ohara: Saffold virus type 3 (SAFV-3) persists in HeLa cells., PLoS
ONE, 8:e53194;1-8, 2013.

0190B002

Y.Muraki, T.Okuwa, T.Himeda, S.Hongo, Y.Ohara: Effect of cysteine mutations in the extracellular domain of CM2
on the Influenza C virus replication., PLoS ONE, 8:e60510;1-10, 2013.

0190B003(T.Mizukoshi), H.Komori, M.Mizuguchi,, H.Abdelaziz, T.Hara, M,Higuchi, Y.Tanaka, Y.Ohara, N.Funato, M.Fujii,
M.Nakamura: Failure in activation of the canonical NF-ҡB pathway by human T-cell leukemia virus type 1 Tax in
non-humatopoietic cell lines., Virology, 443: 226-235, 2013.

Reviews
0190C001

Y.Ohara, T.Himeda: Topics of human cardioviruses., The Journal of Pediatric Infectious Disease and Immunology,
25:446-451, 2013 (in Japanese) .

Others
0190F001

T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara: Possibility of neuropathogenesis of Saffold virus suggested from the invitro virus persistence., Clin. Exp. Neuroimmunol., 4:163-164, 2013.

Presentations at Conference
International Conference (Presentations)
0190I001

Y.Muraki, T.Okuwa, T.Noda, T.Himeda, S.Hongo, Y.Ohara: Analysis of influenza C virus possessing substitutionsin its CM2 transmembrane region, Options for the Control of Influenza VIII, (Cape Town, South Africa, '13).

0190I002

Y.Muraki, T.Okuwa, T.Himeda, S.Hongo, Y.Ohara: Disulphide-linked CM2 oligomers are required for efficient
replication of influenza C virus., 5th International Negative Strand Virus Meeting, (Granada, Spain, '13).
－ 14 －

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology

Professor(Additional Post)

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology

Assistant Professor

TAKEDA Kazuya

Immunology, Neuropathology

Assistant Professor

WADA Toshiki

Immunology, Functional biochemistry, Structural biochemistry

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

Publications
Originals
0200B001(S.Shiota), H.Takekawa, SE.Matsumoto, K.Takeda, F.Nurwidya, Y.Yoshioka, F.Takahashi, N.Hattori, T.Tabira,H.Mochizuki, K.Takahashi: Chronic intermittent hypoxia/reoxygenation facilitate amyloid-β generation in mice, J.
Alzheimers Dis., 37:325-333, 2013.

－ 15 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.2.Epidemiological research of tickborn diseases in the Noto Peninsula,Ishikawa Prefect.

Publications
Originals
0210B001(A.Kobayashi), H.Yokogawa, N.Yamazaki, Y.Ishibashi, Y.Oikawa, M .Tokoro, K.Sugiyama: In vivo laser confocal
microscopy findings of radial keratoneuritis in patients with early stage acanthamoeba keratitis., Ophthalmology,
120:1348-1353, 2013.

0210B002(M.M.Rahman), K.Yagita, A.Kobayashi, Y.Oikawa, A.A.Hussein, T.Matsumura, M.Tokoro: Genetic
characterization of clinical acanthamoeba isolates from Japan using nuclear and mitochondrial small subunit
ribosomal RNA., Korean J. Parasitol., 51:401-411, 2013.

0210B003

Y.Oikawa, H.Fujita, Y.Yano, N.Takada: Simple serodiagnoses of spotted fever group rickettsioses by ELISA using
rickettsial alkali polysaccharide antigen., Med. Entomol. Zool., 64:33-35, 2013 (in Japanese) .

Short Communications
0210E001(Gaowa), N.Ohashi, M.Aochi, Wuritu, D.Wu, Y.Yoshikawa, F.Kawamori, T.Honda, H.Fujita, N .Takada, Y.Oikawa,
H.Kawabata, S.Ando, T.Kishimoto: Rickettsiae in ticks,Japan, 2007-2011, Emerging Infect. Dis., 19:338-340,
2013.

Others0210F001

Y.Oikawa, T.Matsumura, M.Tokoro: A case of Clinostomum sp. in Ishikawa prefecture, Clin. Parasitol., 24:109111, 2013 (in Japanese) .

－ 16 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Senior Assistant Professor

FUKUSHIMA Mana

surgical pathology

Assistant Professor

KOBAYASHI Erikosurgical pathology, molecular pathology

Assistant Professor

NAKADA Satoko

surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001(M. Hirokawa), A. Miyauchi, H.Minato, S. Yokoyama, S. Kuma, M. Kojima: Intrathyroidal epithelial
thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma
and a possibility of development from a multipotential stem cell., APMIS., 121:523-530 , 2013.

0220B002(H.Kimura), Y.Dobashi, T.Nojima, H.Nakamura, N.Yamamoto, H.Tsuchiya, H.Ikeda, S.Sawada-Kitamura,
T.Oyama, A.Ooi: Utility of fluorescence in situ hybridization to detect MDM2 amplification in liposarcomas andtheir morphological mimics., Int J Clin Exp Pathol, 6:1306-1316, 2013.

0220B003

Z.Shang, H.Minato, T.Sasagawa, S.Nakada, E.Kinoshita, N.Kurose, T.Nojima, S.Makinoda: Detection of high-risk
human papillomavirus subtypes in cervical glandular neoplasia by in situ hybridization., Int J Clin Exp Pathol,
6:2168-2177, 2013.

Reviews
0220C001

H.Minato, M.Fukushima, T.Nojima, M.Nakano: Specimen misidentification in pathology laboratory: trends andmeasures., Rinsho Byori, 61：751-759, 2013 (in Japanese) .

－ 17 －

Case Reports
0220D001(H.Nishijima), A.Arai, T.Kon, Y.Funamizu, T.Ueno, R.Haga, Y.Miki, T.Kimura, C.Suzuki, M.Tomiyama, T.Kusumi,
H.Minato, M.Baba: Intracranial immunoglobulin G4-related disease successfully treated by steroid and oral
cyclophosphamide: A case report., Neurol Clin Neurosci., 1:38-40, 2013.

0220D002

Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Japanese variant of multicentirc cattleman's disease associatedwith serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a
distinct clinicopathological entity?, J. Clin. Exp. Hematop., 53:79-85, 2013.

0220D003

T.Kanda, T.Mizuno, M.Ishigaki, K.Nakajima, T.Matsue, M.Fukushima, H.Minato, N.Nojima, S.Atsushi, K.Ishigami,
H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, A.Fukuda, Y.Izumi, N.Takekoshi:
Spontaneous remission of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly., Case Rep
Oncol., 6:269-274, 2013.

0220D004

K.Fukui, A.Kaneuji, E.Kinoshita, Y.Numata, T.Nojima, T.Matsumoto: Localized pigmented villonodular synovitis of
the hip: sudden-onset pain caused by torsion of the tumor pedicle., Case Rep Orthop., 2013:862935;1-4, 2013.

0220D005(R.Niimi), A.Matsumine, T.Nakamura, R.Morimoto, T.Murata, T.Suzuki, Y.Nakashima, T.Nojima, A.Uchida,
A.Sudo: Ewing's sarcoma with an uncommon clinical course: A case report, Oncol. Lett., 6:9-12, 2013.

0220D007

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, E.Kinoshita, T.Nojima: A case of renal pelvic urothelial carcinoma
with sarcomatous change., Japanese Journal of Clinical Urology, 67:269-272, 2013 (in Japanese) .

0220D008

A.Nishio, K.Shimada, M.Yamashita, C.Yoshida, S.Kawakami, S.Nakada, H.Minato: True prehallux-like deformity of
the left foot;a case report., The Japanese journal of plastic & reconstructive surgery., 56:541-545, 2013 (inJapanese) .

0220D010

N.Ueda, J.Fujita, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, M.Noguchi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano,
T.Kosaka, H.Minato, H.Takamura: Surgical resection of multiple liver metastases of rectal neuroendocrine tumors.,
Cancer & chemotherapy, 40:1840-1842, 2013 (in Japanese) .

0220D011

I.Chikazawa, S.Miura, S.Nishida, K.Miyazawa, T.Tanaka, K.Suzuki, S.Nakata, T.Nojima: Spontaneous rupture of
renal cell carcinoma arising in the native kidney following living renal transplantation : A case report, 泌外,
26:1741-1744, 2013 (in Japanese) .

Others
0220F001

N.Hayashi, H.Okuyama, Y.Matsui, H.Yamaya, E.Kinoshita, H.Minato, Y.Niida, H.Yokoyama: Adult-onset renal
failure in a family with Alagille syndrome with proteinuria and a novel JAG1 mutation., Clin Kidney J, 6:295-299,
2013.

－ 18 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseasesProfessor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stressSenior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stressSenior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence
from practice at a worksite in Japan., PLoS ONE, 8:e55836;1-9, 2013.

0230B002

Y.Morikawa, M.Sakurai, K.Nakamura, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Correlation
between shift-work-related sleep problems and heavy drinking in Japanese male factory workers., Alcohol Alcohol.,
48:202-206, 2013.

0230B003

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Sasaki, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, H.Nakagawa: Family histry of diabetes, lifestyle factors, and the 7-year incident risk oftype 2 diabetes mellitus in middle-aged Japanese men and women., J Diabetes Investig, 4:261-268, 2013.

0230B004(R.Sato), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, Y.Suwazono: Twenty-two-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan., Open J
Nephrol., 3:205-210, 2013.

0230B005

Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, Y.Yamada: Elevated serum gamma-glutamyltransferase (GGT)
activity and the development of chronic kidney disease (CKD) in cigarette smokers., Nephrourol Mon, 5:967-973,
2013.

0230B006

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: The effects of continuing anddiscontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working
population in Japan., Environ. Health Prevent. Med., 18:24-32, 2013.

－ 19 －

0230B007

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Distribution of and factors
contributing to chronic kidney disease in a middle-aged working population., Environ. Health Prevent. Med., 18：466-476, 2013.

0230B008

M.Ishizaki, N.Kawakami, R.Honda, Y.Yamada, H.Nakagawa, Y.Morikawa, The Work Stress and Health Cohort
Study Group: A prospective study of psychosocial work characteristics and long sick leave of Japanese male
employees in multiple workplaces., Ind. Health, 51:398-405, 2013.

0230B009(W.Ruangyuttikarn), A.Panyamoon, K.Nambunmee, R.Honda, W.Swaddiwudhipong, M.Nishijo: Use of the kidney
injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically
exposed to cadmium in the environment., Springerplus, 2:533;1-8, 2013.

0230B010

PT.Tai, M.Nishijo, N.Thi Nguyet Anh, S.Maruzeni, H.Nakagawa, H.Van Luong, T.Hai Anh, R.Honda, T.Kido,
H.Nishijo: Dioxin exposure in breast milk and infant neurodevelopment in Vietnam., Occup. Environ. Med.,
70:656-662, 2013.

Reviews
0230C001

Y.Noborisaka: Smoking and chronic kidney disease in healthy populations, Nephrourol Mon, 5:655-667, 2013.

0230C002

Y.Yamada, Y.Noborizaka, M.Ishizaki: Chronic kidney disease(CKD) as an emerging lifestyle disease., Hokuriku
Japanese Journal of Public Health., 39：21-27, 2013 (in Japanese) .

Others0230F001

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Inspection osteoporosis using ultrasound by
visualization of internal microstructure of heel bone., Proceeding of the 7th World Congress of the International
Society of Physical and Rehabilitation Medicine, 239-243, 2013.

0230F002

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Arteriosclerotic and ruptured blood vessel appear
as a change in the dynamic property of vessel wall dynamic deformability and strength by carotid artery echo.,
Proceeding of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine, 244245, 2013.

Presentations at Conference
International Conference (Synposium)
0230H001

M.Nakata: The history of WRMSDs in Japan: how it emerged, spread, and how it is today, 8th International
Conference on Prevention of Work-Related Musculoskeletal Disorders, (Busan, '13.07)，8th International
Conference on Prevention of Work-Related Musculoskeletal Disorders ABSTRACTS, p51, 2013.

International Conference (Presentations)
0230I001

Y.Yamada, Y.Noborisaka, M.Ishizaki, R.Honda, H.Yokoyama, M.Tabata, M.Miyao: Risk factors related to thedevelopment of chronic kidney disease (CKD) in middle-aged workers, 6th ICOH International Conference on
Work Environment and Cardiovascular Disease, (Tokyo, '13.03)，6th ICOH International Conference on Work
Environment and Cardiovascular Disease. Abstract Book, p41, 2013.

0230I002

M.Nakata, Y.Yamada, K.Kagechica, PO.Eriksson: Intervention on work-related musculoskeletal
disorders(WRMSDs) and depression among factory workers, a pilot study, 8th International Conference on
Prevention of Work-Related Musculoskeletal Disorders, (Busan, '13.07)，8th International Conference on
Prevention of Work-Related Musculoskeletal Disorders ABSTRACTS, p214, 2013.

0230I003

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Rice consumption and incident risk for type 2 diabetes in Japanese men andwomen., 73rd Scientific Sessions, American Diabetes Association, (Chicago, IL, USA, '13).

－ 20 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Associate Professor

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

NAKANISHI Yumiko

Preventive medicine

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Books
0240A002(T.Kido), R.Okamoto(Naganuma), H.Suzuki, S.Honma, P.T.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa, K.Tawara,
D.D.Nhu, N.N.Hung, K.Son le: Dioxins in human breast milk in Vietnam, Hand book of dietary and nutritional
aspects of human breast milk (Sherma Zibadi, Ronald Ross Watson, Victor R.Preedy), 777-796, Wagreningen
Academic, VietnamT.Kido, 2013.

Publications
Originals
0240B001

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence
from practice at a worksite in Japan., PLoS ONE, 8:e55836;1-9, 2013.

－ 21 －

0240B002(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women, Endocrinology, 170:131-139, 2013.

0240B003

Y.Morikawa, M.Sakurai, K.Nakamura, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Correlation
between shift-work-related sleep problems and heavy drinking in Japanese male factory workers., Alcohol Alcohol.,
48:202-206, 2013.

0240B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Sasaki, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, H.Nakagawa: Family histry of diabetes, lifestyle factors, and the 7-year incident risk oftype 2 diabetes mellitus in middle-aged Japanese men and women., J Diabetes Investig, 4:261-268, 2013.

0240B005(Y.Murakami), T.Okamura, K.Nakamura, K.Miura, H.Ueshima: The clustering of cardiovascular disease risk factors
and their impacts on annual medical expenditure in Japan: community-based cost analysis using Gamma regression
models., BMJ Open, 3:e002234, 2013.

0240B006(R.Sato), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, Y.Suwazono: Twenty-two-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan., Open J
Nephrol., 3:205-210, 2013.

0240B007

K.Nakamura, K.Miura, H.Nakagawa, T.Okamura, N.Okuda, K.Nishimura, S.Yasumura, K.Sakata, H.Hidaka,
A.Okayama: Treated and untreated hypertension, hospitalization, and medical expenditure: an epidemiologicalstudy in 314 622 beneficiaries of the medical insurance system in Japan., J. Hypertens., 31:1032-1042, 2013.

0240B008(K.Miura), J.Stamler, I.J.Brown, H.Ueshima, H.Nakagawa, M.Sakurai, Q.Chan, L.J.Appel, A.Okayama, N.Okuda,
J.D.Curb, B.L.Rodriguez, C.Robertson, L.Zhao, P.Elliott, for the intermap reserch group: Relationship of dietarymonounsaturated fattty acids to blood pressure: the international study of macro/micronutrients and bloodpressure., J. Hypertens., 31:1144-1150, 2013.

0240B009

A.T.N.Nguyen, M.Nishijo, E.Hori, N.M.Nguyen, T.T.Pham, K.Fukunaga, H.Nakagawa, A.H.Tran, H.Nishijo:
Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspringrats., Environ Health., 7:1-14, 2013.

0240B010(MN.Nguyen), M.Nishijo, ATN.Nguyen, A.Bor, T.Nakamura, E.Hori, H.Nakagawa, T.Ono, H.Nishijo: Effects ofmaternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on parvalbumin-and calbindin-immunoreactive neurons
in the limbic system and superior colliculus in rat offspring., Toxicology, 314:125-134, 2013.

0240B011(T.Hisamatsu), T.Ohkubo, K.Miura, T.Yamamoto, A.Fujiyoshi, N.Miyagawa, A.Kadota, N.Takashima, S.Nagasawa,
Y.Kita, Y.Murakami, A.Okayama, M.Horie, T.Okamura, H.Ueshima, H.Nakagawa, for the NIPPON DATA90
research group: Association between J-point elevation and death from coronary artery disease, Circ. J., 77:12601266, 2013.

0240B012

M.Sakurai, S.Saitoh, K.Miura, H.Nakagawa, H.Ohnishi, H.Akasaka, A.Kadota, Y.Kita, T.Hayakawa, T.Ohkubo,
A.Okayama, T.Okamura, H.Ueshima, for the NIPPON DATA 90 Research Group: HbA1c and the risks for allcause and cardiovascular mortality in the general Japanese population: NIPPON DATA90., Diabetes Care.,
36:3759-3765, 2013.

0240B013(T.Inohara), S.Kohsaka, T.Okamura, M.Watanabe, Y.Nakamura, A.Higashiyama, A.Kadota, N.Okuda, T.Ohkubo,
K.Miura, A.Okayama, H.Ueshima, H.Nakagawa, for the NIPPON DATA 80/90 reserch group: Long-term outcomeof healthy participants with atrial premature complex: a 15-year follow-up of the NIPPON DATA 90 cohort., PLoS
ONE, 11:e80853;1-7, 2013.

0240B014(A.Kadota), K.Miura, T.Okamura, A.Fujiyoshi, T.Ohkubo, T.Kadowaki, N.Takashima, T.Hisamatsu, Y.Nakamura,
F.Kasagi, H.Maegawa, A.Kashiwagi, H.Ueshima, H.Nakagawa, for the SESSA research group and for the NIPPONDATA80/90 research group: Carotid intima-media thickness and plaque in apparently healthy Japanese individuals
with an estimated 10-year absolute risk of CAD death according to the Japan atherosclerosis society (JAS)guidelines 2012: The Shiga epidemiorlogical study of subclinical atherosclerosis(SESSA), J. Atheroscler. Thromb.,
20:755-766, 2013.

0240B015

M.Ishizaki, N.Kawakami, R.Honda, Y.Yamada, H.Nakagawa, Y.Morikawa, The Work Stress and Health Cohort
Study Group: A prospective study of psychosocial work characteristics and long sick leave of Japanese male
employees in multiple workplaces., Ind. Health, 51:398-405, 2013.

－ 22 －

0240B016(H.D.Manh), T.Kido, R.Okamoto, S.X.Liang, N.H.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, D.V.Tung, D.D.Nhe, N.N.Hung, L.K.Son: The relationship between dioxins and salivary
steroid hormones in Vietnamese primiparae., Environ. Health Prevent. Med., 18:221-229, 2013.

0240B017(GM.Singh), G.Danaei, F.Farzadfar, GA.Stevens, M.Woodward, D.Wormser, S.Kaptoge, G.Whitlock, Q.Qiao,
S.Lewington, E.Di Angelantonio, S.Vander Hoorn, CM.Lawes, MK.Ali, D.Mozaffarian, M.Ezzati, M.Sakurai,
H.Nakagawa, K.Nakamura, Y.Morikawa, Global Burden of Metabolic Risk Factors of Chronic Diseases
Collaborating Group: Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE);
Emerging Risk Factor Collaboration (ERFC); Prospective Studies Collaboration (PSC). The age-specificquantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis., PLoS
ONE, 8:e65174;1-10, 2013.

0240B018(W.Ruangyuttikarn), A.Panyamoon, K.Nambunmee, R.Honda, W.Swaddiwudhipong, M.Nishijo: Use of the kidney
injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically
exposed to cadmium in the environment., Springerplus, 2:533;1-8, 2013.

0240B019

PT.Tai, M.Nishijo, N.Thi Nguyet Anh, S.Maruzeni, H.Nakagawa, H.Van Luong, T.Hai Anh, R.Honda, T.Kido,
H.Nishijo: Dioxin exposure in breast milk and infant neurodevelopment in Vietnam., Occup. Environ. Med.,
70:656-662, 2013.

0240B020(S.Satarug), W.Swaddiwudhipong, W.Ruangyuttikarn, M.Nishijo, P.Ruiz: Modeling cadmium exposures in low- andhigh-exposure areas in Thailand., Environ. Health Perspect., 121:531-536, 2013.

0240B021

M.Nishijo, TN.Nghi, HD.Manh, PT.Tai, NTN.Anh, PHA.Vu, NT.Nguyen, NX.Hung, HM.Hoan, HC.Hai, H.Nishijo,
T. Hai-Anh, HV.Luong, T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Dioxin concentration in breast milk ofprimipara mothers in Bien Hoa, a hot spot area in Vietnam －A preliminary study in 2012－., Organohalogen
Compounds., 75:1167-1170, 2013.

0240B022(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV.Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., Organohalogen Compounds., 75:1321-1324, 2013.

0240B023(HD.Manh), T.Kido, R.Okamoto, XL.Sun, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: Current elevated dioxin level in serum of Vietnamese old men: Past exposure or
current exposure., Organohalogen Compounds., 75:1316-1320, 2013.

0240B024(XL.Sun), T.Kido, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: The relationship between dioxin and steroid hormones in serum of Vietnamese men.,
Organohalogen Compounds., 75:314-317, 2013.

0240B025(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa, N.Nemoto, A.Yokoyama, H.Kimura: SEM-EDX Elemental
content maps of organisms in radioac-tive environmental pollution by FDNPP accident in 2011., Kahokugata Lake
Science, 16:7-24, 2013 (in Japanese) .

0240B026(T.Koyama), S.Yamamoto, K.Yoshida, Y.Arai, M.Sakurai, K.Nakamura, M.Nishijyo, Y.Nakanishi, S.Nagasawa,
Y.Morikawa, M.Tabata, H.Nakagawa: Calcium intake and associated other dietary factors in healthy enderly
people., Hokuriku Japanese Journal of Public Health., 40:6-13, 2013 (in Japanese) .

0240B027(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa: Distribution of Sr,Cs,Np,and Pu in radioactive polluted paddy
soils and organisms., Journal of Fossil Research, 46：35-57, 2013 (in Japanese) .

0240B028

M.Nakashima, Y.Morikawa, Y.Hamazaki, S.Sakurai, J.Kitagawa, M.Sakurai, H.Nakagawa: Total smoking ban on an
university campus and acquisition of smoking habits., Jpn J School Health, 55:396-401, 2013 (in Japanese) .

Reviews
0240C003

M.Sakurai: Usefulness of glycated hemoglobin (HbA1c) measurement in healthy adults., Hokuriku Japanese Journalof Public Health., 40:1-5, 2013 (in Japanese) .

－ 23 －

Others
0240F001(H.Teranishi), M.Nishijo: Environmental Cadmium Conference 2013: Health risk of environmental cadmium
contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M, Ruangyuttikarn W eds) Lessons
from itai-itai disease and cadmium pollution in Japan, Chiang Mai University, 4-8, 2013.

0240F002

M.Nishijo, S.Maruzeni, K.Nakamura, H.Nakagawa: Environmental Cadmium Conference 2013: Health risk ofenvironmental cadmium contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M,
Ruangyuttikarn W eds) Mortality of itai-itai disease patients and residents in a Cd polluted Jinzu River basin,
Toyama, Japan, Chiang Mai University, 9-14, 2013.

Presentations at Conference
International Conference (Presentations)
0240I001

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, M.Nakashima, H.Nakagawa: Relationship between houseboundstatus and onset of need for ling term care among the elderly in arural town, The 5th international conference oncommunity health nursing research, (Edinburgh UK, '13.03).

0240I002

M.Nishijo, TN.Nghi, HD.Manh, PT.Tai, NTN.Anh, PHA.Vu, NTNguyen., NX.Hung, HM.Hoan, HC.Hai, H.Nishijo,
T.Hai-Anh, HV.Luong, T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Dioxin concentration in breast milk ofprimipara mothers in Bien Hoa, a hot spot area in Vietnam － A preliminary study in 2012－., The 33rd
international Symposium on Halogenated Persistent Organic pollutants - Dioxin 2013, (Daegue, Korea, '13.08).

0240I003(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV. Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LKSon., Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., The 33rd international Symposium on Halogenated Persistent Organic pollutants Dioxin 2013, (Daegue, Korea, '13.08).

0240I004

M.Sakurai, LM.Oude Griep, ML.Daviglus, DB.Garside, L.Van Horn, K.Miura, H.Nakagawa, H.Ueshima, Q.Chan,
P.Elliott, J.Stamler, for the INTERMAP Research Group: Dietary intakes of rice, bread, pasta, potatoes and bloodpressure: the International Study of Macro/Micro-nutrients and Blood Pressure (INTERMAP)., 2013 Scientific
Sessions, Cardiovascular Disease, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, (New
Orleans, LA, USA, '13).

0240I005

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Rice consumption and incident risk for type 2 diabetes in Japanese men andwomen., 73rd Scientific Sessions, American Diabetes Association, (Chicago, IL, USA, '13).

－ 24 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology, Drug Dependence

Associate Professor

WANG Lu elaine

Tumor pathology, Endocrine pathology, Forensic pathology

Assistant Professor

TAKEICHI Toshiaki

ER-stress, Drug Dependence

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Case Reports
0250D001

L.Wang, Y.Sato, T.Takeichi, O.Kitamura: Sudden death of an infant with coronary involvement due to Takayasu
arteritis., Cardiovasc. Pathol., 22:109-111, 2013.

－ 25 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

HORI Ariyuki

Professor

YASUDA Yukio

Assistant Professor

KURODA Naohiro

Faculty

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
undergraduate clinical teaching, graduate education of physicians,
medical education
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

－ 26 －

Clinical Medicine

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Professor(Additional Post)

ASAJI Takayoshi

Heart failure

Associate Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Associate Professor

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention

Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Assistant Professor

TANABE Kan

Heart failure

Assistant Professor

WATANABE Makoto

Ischemic heart disease,，Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system－ 27 －

Publications
Originals
0300B001

K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami: Chk1-mediated phosphorylation of receptor-associated latetransducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., Genes Cells, 18:369386, 2013.

0300B002

H.Aoki, I.Matsunari, Y.Nomura, W.Fujita, R.Komatsu, Y.Miyazaki, SG.Nekolla, K.Kajinami: Myocardial
sympathetic innervation, function, and oxidative metabolism in non-infarcted myocardium in patients with priormyocardial infarction, Ann. Nucl. Med., 27:523-531, 2013.

Presentations at Conference
International Conference (Presentations)
0300I001

M.Watanabe: Impact of Staged Repetitive Endovascular Threapy Combined with Continuous Intra-arterial
Thrombolysis in Acute Limb Ischemia with Massive Thrombus, TCTAP2013, (Seoul, '13.03).

0300I002

T.Takamura: Retro-grade Zilver PTX Stent Delivery from Tibial Artery in Endovascular Therapy for Complex
Lesion of Superficial Femoral Artery, TCTAP2013, (Seoul, '13.04).

0300I003

M.Wakasa, K.Kajinami, M.Kitayama, Y.Kawai, H.Akao, N.Fujioka, H.Aoki, K.Fujibayashi, K.Tanabe, W. Fujita:
Association of ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA) with the washout rate of tc99msestambi in patients with cardiomyopathy, Heart Failure Congress 2013, (Lisbon, '13.05).

0300I004

H.Aoki: Prognostic value of left ventricular dyssynchrony assessed by ECG-gated Tc-99m tetrofosmin SPECT
with phase analysis in patients with chronic kidney disease and narrow ORS, Heart Failure Congress 2013, (Lisbon,'13.05).

0300I005

K.Kajinami, E.Ueno, K.Tanabe, N.Fujioka, H.Akao, T.Tsuchiya, Y.Kawai, M.Kitayama: Effects of High-Dose
Atorvastatin Monotherapy on Circulating PCSK9 Levels in Heterozygous Familial Hypercholeserolemia, 81st EAS
Congress, (Lyon, '13.06).

0300I006

H.Akao, E.Polisecki, K.Kajinami, I.Ford, J.W.Jukema, A.J.M.De Craen, R.G.J.Westendorp, C.Packard,
E.J.Schaefer: The ABCA1 gene variant and heart disease risk reduction in the elderly during pravastatin
treatment, ESC CONGRESS 2013, (Amsterdam, '13.08).

0300I007

K.Kajinami, K.Takeda, K.Maeda, Y.Sugiyama, Y.Sugiyama, I.Ieiri, T.Masaugi, N.Fukizawa: SLCO1B1
polymorphisms affect atorvastatin pharmacokinetics and cholesterol-lowering effects in patients withhypercholesterolemia in a microdosing approach, ESC CONGRESS 2013, (Amsterdam, '13.08).

－ 28 －

0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Associate Professor

MIZUNO Shirolung cell and molecular biology，COPD

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Senior AssistantProfessor(Additional Post)

IGUCHI Masaharu

clinical respiratory medicine

Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

KOBAYASHI Makoto lung cell and molecular biology

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

YAMAYA Atsuyo

clinical respiratory medicine

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

KAMEDA Mari

clinical respiratory medicine

Assistant Professor

SHINOMIYA Shohei

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001(M.Yasuo), S.Mizuno, J.Allegood, D.Kraskauskas, H.J.Bogaard, S.Spiegel, N.F.Voelkel: Fenretinide causes
emphysema, which is prevented by sphingosine 1-phoshate., PLoS ONE, 8:e53927;1-10, 2013.

0310B002

S.Shinomiya, T.Shibamoto, Y.Kurata, Y.Kuda, W..Zhang, M.Tanida, H.Toga: Nitric oxide and β2-adrenoceptor
activation attenuate pulmonary vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice.,Exp. Lung Res., 39:119-129, 2013.

－ 29 －

0310B003(J.G.Arroyo), S.Mizuno, K.Szczepanek, B.V.Tassell, R.Natarajan, C.G.dos Renoeios, J.I.Drake, L.Farkas,
D.Kraskauskas, D.S.Wijesinghe, C.E.Chalfant, J.Bigbee, A.Abbate, E.J.Lesnefsky, H.J.Bogaard, N.F.Voelkel:
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy because of
pulmonary arterial hypertension, Circ Heart Fail., 6:136-1444, 2013.

0310B004(A.A.Husseini), G.Bagnato, L.Farkas, J.G.Arroyo, D.Farkas, S.Mizuno, D.Kraskauskas, A.Abbate, B.V.Tassel,
N.F.Voelkel, H.J.Bogaard: Thyroid hormone is highly permissive in angioproliferative pulmonary hypertention inrats, Eur. Respir. J., 41:104-114, 2013.

0310B005

Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya,
M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno,
K.Osanai, H.Toga: A three-microphone acoustic reflection technique using transmitted acoustic waves in the
airway, J. Appl. Physiol., 115:1119-1125, 2013.

0310B006

A.Sakai, H.Toga, O.Tachibana, T.Miwa: Assessment of treatment effect for acromegaly with sleep disorderedbreathing., Journal of Otolaryngology of Japan, 116:612-618, 2013 (in Japanese) .

Reviews
0310C001(N.F.Voelkel), S.Mizuno, H.J.Bogaard: The role of hypoxia in pulmonary vascular diseases: a perspective, Am. J.
Physiol. Lung Cell Mol. Physiol., 304:L457-L465, 2013.

0310C002(N.F.Voelkel), S.Mizuno, Y.Masanori: Does drug-induced emphysema exist?, Eur. Respir. J., 42:1464-1468, 2013.

Case Reports
0310D001

M.Saito, T.Oikawa, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga: A case of lung abscess caused by communityacquired methicillin-resistant Staphylococcus aureus, The journal of the Japanese Respiratory Society., 2:295-299,
2013 (in Japanese) .

0310D002

T.Oikawa, R.Kato, K.Nakagawa, S.Mizuno, K.Osanai, H.Toga: A case of empyema thoracis by Nocardia farcinica
successfully treated with sitafloxacin, The journal of the Japanese Respiratory Society., 2:424-428, 2013 (inJapanese) .

Others
0310F001(H.J.Bogaard), S.Mizuno, N.F.Voelkel: Letter by bogaard et al regarding article, "histone deacetylation inhibitionin pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid",
Circulation, 127:e539, 2013.

Presentations at Conference
International Conference (Synposium)
0310H001

S.Mizuno, T.Ishizaki, M.Kobayashi, K.Osanai, H.Toga: Gene polymorphisms of p53 at aodon 72 and MDM2
SNP309 regulates lung cell proliferation during hypoxia, VIII Congress of euro-asian respiratory society
international symposium, (Kyrgys, '13.11).

International Conference (Presentations)
0310I001

S.Mizuno, T.Ishizaki, M.Kadowaki, J.G.Gomez, D.Kraskauskas, N.F.Voelkel, K.Osanai, H.Toga: Gene
polymorphisms of p53 at codon 72 and MDM2 SNP309 are associated with emphysematous changes in COPD
patients, ATS 2013 International Conference, (Philadelphia, '13)，Am. J. Respir. Crit Care Med., 187:A5516,
2013.

－ 30 －

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Faculty

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Senior Assistant Professor

NAKAMURA
Masakatsu

Senior Assistant Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Senior AssistantProfessor(Additional Post)SHIMASAKI Takeo

Molecular Oncology, Pancreatic cancer , tissue engineering．

Senior Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Assistant Professor

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

Assistant Professor

MATSUNAGA
Kazuhiro

Diserders of billary duct and pancreas

Assistant Professor

HAYASHI Ranji

Inflammatory Bowel Disease

Endoscopic thcrapy of early gastric cancer

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0320B001

N.Toshikuni, A.Fukumura, N.Hayashi, T.Nomura, M.Tsuchishima, T.Arisawa, M.Tsutsumi: Comparison of therelationships of alcoholic and nonalcoholic fatty liver with hypertension,diabetes mellitus,and dyslipidemia., J. Clin.
Biochem. Nutr., 52:82-88, 2013.

－ 31 －

0320B002

N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna,
Y.Motoo: Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabinesensitivity., Mol Clin Oncol., 1:100-104, 2013.

0320B003(A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai,
K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto: Aberrant glycogen synthase kinase 3β is involved in pancreaticcancer cell invasion and resistance to therapy., PLoS ONE, 8:e55289;1-12, 2013.

0320B004

N.Hayashi, J.George, H.Shiroeda, T.Saito, N.Toshikuni, M.Tsuchishima, T.Arisawa, M.Tsutsumi: Irsogladine
maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon andribavirin: a pilot study., J. Gastroenterol. Hepatol., 28:1015-1018, 2013.

0320B005

N.Hayashi, J.George, M.Takeuchi, A.Fukumura, N.Toshikuni, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived
advanced glycation end-products promote alcoholic liver disease., PLoS ONE, 8:e70034;1-14, 2013.

0320B006

M.Tsuchishima, J.George, H.Shiroeda, T.Arisawa, T.Takegami, M.Tsutsumi: Chronic ingestion of ethanol induces
hepatocellular carcinoma in mice without additional hepatic insult., Dig. Dis. Sci., 58:1923-1933, 2013.

0320B007

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

0320B008

N.Toshikuni, H.Shiroeda, K.Ozaki, Y.Matsue, T.Minato, T.Nomura, N.Hayashi, T.Arisawa, M.Tsutsumi: Advanced
ultrasonography technologies to assess the effects of radiofrequency ablation on hepatocellular carcinoma., Radiol
Oncol., 47:224-229, 2013.

0320B009

T.Nomura, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura,
N.Toshikuni, T.Shibata, T.Arisawa: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of
DAPK and CDH1 in the gastric epithelium., BMC Gastroenterol., 13:1471-1479, 2013.

0320B010

T.Arisawa, T.Tahara, H. Shiroeda, T.Minato, Y.Matsue, T.Saito, T.Fukuyama, T.Otsuka, A.Fukumura,
M.Nakamura, T.Shibata: Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese
subjects., J. Gastroenterol., 48:73-80, 2013.

0320B011

R.Hayashi, T.Tahara, H.Shiroeda, T.Saito, M.Nakamura, M.Tsutsumi, T.Shibata, T.Arisawa: Influence of IL17A
polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis, Clin. Exp. Med., 13:239-244,
2013.

0320B012

T.Arisawa, T.Tahara, H.Shiroeda, K.Yamada, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka,
M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata: Functional promoter polymorphisms of NFKB1
influence susceptibility to the diffuse type of gastric cancer., Oncol. Rep., 30:3013-3019, 2013.

0320B013(T.Tahara), S.Maegawa, W.Chung, J.Garriga, J.Jelinek, MRH.Estécio, T.Shibata, I.Hirata, T.Arisawa, JPJ.Issa:
Examination of whole blood DNA methylation as a potential risk marker for gastric cancer., Cancer Prev. Res.
(Phila. Pa)., 6:1093-1100., 2013.

Case Reports
0320D001

M.Nakamura, H.Shioeda, T.Tahara, T.Shibata, T.Arisawa: A new attachment hood (Nanoshooter) for transnasal
endoscopic submucosal dissection of the hypopharynx., Endoscopy, 45:E387-388, 2013.

Others
0320F001(T.Tahara), T.Arisawa: Genetic and epigenetic interaction in the development of colorectal cancers., Hum Genet
Embryol., 3:2, 2013.

0320F002(T.Tahara), T.Arisawa, T.Shibata, N.Ohmiya, I.Hirata: Aberrant DNA methylation as sensitive and promisingbiomarkers in diagnosing of cancers., Transl Gastrointest Cancer., 2:80-82, 2013.

－ 32 －

Presentations at Conference
International Conference (Presentations)
0320I001

T.Arisawa, K.Matsinaga, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Otsuka, N.Toshikuni,
H.Shiroeda, T.Shibata: Genetic polymorphism of MAFK (Rs4268033)is associated with the susceptibility to gastriccancer in japan, Digestive Disease Week 2013, (Orlando, '13.05).

0320I002

T.Arisawa, H.Shiroeda, T.Tahara, M.Nakamura, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka,
N.Toshikuni, T.Shibata: Genetic polymorphism of NFKB1(rs28362491,-94 ATTG ins/gel)is associated with agerelated gene methylation in helicobacter pylori infected japanese subjects., Digestive Disease Week 2013,(Orlando, '13.05).

0320I003

T.Arisawa, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
H.Shiroeda, T.Shibata: T:A Genetic polymorphism of MAFK gene is closely associated with the severity of gastricmucosal atrophy., Digestive Disease Week 2013, (Orlando, '13.05).

0320I004

T.Arisawa, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
H.Shiroeda, T.Shibata: An association between genetic polymorphisms of ripk2(Ile259thr and *35la>G)and thesusceptibility to gastric cancer in japan., Digestive Disease Week 2013, (Orlando, '13.05).

0320I005

T.Arisawa, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
H.Shiroeda, T.Shibata: Genetic polymorphism of NFKB1(rs28362491,-94 ATTG ins/del) is associated with thesusceptibility to the gastric carcinogenesis in japan., Digestive Disease Week 2013, (Orlando, '13.05).

0320I006

T.Arisawa, T.Otsuka, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Toshikuni,
H.Shiroeda, T.Shibata: Genetic polymorphisms of MAFK,encoding small maf protein MAFK,are associated with thesusceptibility to ulcerative colitis., Digestive Disease Week 2013, (Orlando, '13.05).

0320I007

T.Arisawa, H.Yamada, T.Tahara, M.Nakamura, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
H.Shiroeda, M.Tsutsumi, T.Shibata: The genetic polymorphism of pre-,icroRNA938,targeting IL-17A 3'-UTR,isassociated with the rick for DAP-kinase hypermethylation in helicobacter pylori infected japanese subjects.,
Digestive Disease Week 2013, (Orando, '13.05).

0320I008

N.Toshikuni, N.Hayashi, A.Fukumura, Y.Matsue, T.Minato, T.Nomura, T.Saito, K.Ozaki, H.Shiroeda,
M.Tsuchishima, T.Arisawa, M.Tsutsumi: Differentiation of alcoholic liver disease from nonalcoholic fatty liverdisease using a logistic regression model based on clnical parameters., Digestive Disease Week 2013, (Orlando,'13.05).

0320I009

M.Nakamura, H.Shiroeda, T.Tahara, T.Shibata, T.Arisawa: Usefulness of a nonshooter as a tool for SED of narroworgan lumen with a trens nasal endoscope., Digestive Disease Week 2013, (Orando, '13.05).

0320I010

M.Nakamura, H.Shiroeda, T.Tahara, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
T.Shibata, T.Arisawa: Application of the new WHO classification and the possibility of molecular-targeted
therapies against colorectal neuroendocrine tumors., Digestive Disease Week 2013, (Orlando, '13.05)，Orlando.

0320I011

T.Shimasaki, Y.Ishigaki, A.Kitano, T.Takata, T.Arisawa, N.Ueda, T.Kosaka, T.Takegami, Y.Motoo, N.Tomosugi,
T.Minamoto: Glycogen synthase kinase 38 inhibition sensitizes pancreatic cancer to gemcitabine., Digestive
Disease Week 2013, (Orlando, '13.05).

0320I012

J.George, N.Hayashi, M.Takeuchi, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived advanced glycation endproducts promote alcholic liver disease., Digestive Disease Week 2013, (Orlando, '13.05).

0320I013

N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi, T.Arisawa: Serum endocan as a novel prognostic biomarker inhepatocellular carcinoma patients, 21th United European Gastroenterology Week Berlin,Germany, (Germany,'13.10).

0320I014

T. Arisawa, T. Tahara, T. Shibata, N. Kawada, K. Matsunaga, Nakamura: GENETIC POLYMORPHISMS OF
MAFK ARE ASSOCIATED WITH THE ABERRANT DNA METHYLATION OF CDKN2A IN JAPANESESUBJECTS, 21th United European Gastroenterology Week, (Berlin, Germany, '13.10).

－ 33 －

0320I015

T. Arisawa, T. Tahara, M. Nakamura, H. Yamada, T. Nomura, R. Hayashi, K. Matsunaga, N. Kawada, T. Otsuka,
T. Shimasaki, N. Toshikuni, H. Shiroeda, T. Shibata: GENETIC POLYMORPHISM OF MYD88 GENE (RS7744) IS
CLOSELY ASSOCIATED WITH THE SUSCEPTIBILITY TO ULCERATIVE COLITIS, 21th United European
Gastroenterology Week, (Berlin, Germany, '13.10).

0320I016

T. Arisawa, T. Tahara, M. Nakamura, K. Matsunaga, N. Kawada, T. Shibata: NFKB1 POLYMORPHISM(RS28362941, -94 ATTG INS/DEL) IS ASSOCIATED WITH THE SUSCEPTIBILITY TOULCERATIVE COLITIS,
21th United European Gastroenterology Week, (Berlin, Germany, '13.10).

0320I017(T. Tahara), T. Shibata, M. Okubo, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T. Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: CLINICOPATHOLOGICAL AND MOLECULARANALYSIS OF EPSTEIN–BARR VIRUS POSITIVE GASTRIC CARCINOMA, 21th United European
Gastroenterology Week, (Berlin, Germany, '13.10).

0320I018(T. Tahara), T. Shibata, M. Okubo, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T. Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: CHANGE IN DNA METHYLATION PATTERN OF
SLC6A4 IN THE GASTRIC MUCOSA MAY HAVE A ROLE FOR DEVELOPING FUNCTIONAL DYSPEPSIA,
21th United European Gastroenterology Week, (Berlin, Germany, '13.10).

0320I019(T. Tahara), M. Okubo, T. Shibata, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T. Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: COMMON FUNCTIONAL GENETICPOLYMORPHISMS ASSOCIATED WITH SURVIVAL OF GASTRIC CANCER PATIENTS, 21th United European
Gastroenterology Week, (Berlin, Germany, '13.10).

0320I020(T. Tahara), T. Shibata, M. Okubo, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T. Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: EFFECT OF COMMON FUNCTIONAL GENETICPOLYMORPHISMS ON CPG ISLAND METHYLATION IN NONNEOPLASTIC GASTRIC MUCOSA, 21th United
European Gastroenterology Week, (Berlin, Germany, '13.10).

0320I021(T. Tahara), T. Shibata, M. Okubo, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T. Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: TELOMERE LENGTH IN NON-NEOPLASTICGASTRIC MUCOSA CORRELATES WITH H. PYLORI INFECTION,DEGREE OF GASTRITIS AND NONSTEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS) USE, 21th United European Gastroenterology Week,(Berlin, Germany, '13.10).

0320I022(M. Okubo), T. Tahara, T. Shibata, T. Ishizuka, Y. Ichikawa, M. Miyata, K. Sumi, T.Kawamura, M. Nakamura, M.
Nagasaka, Y. Nakagawa, N. Ohmiya, T. Arisawa, I. Hirata: TELOMERE LENGTH IN NON-NEOPLASTIC
COLONIC MUCOSA IN ULCERATIVE COLITIS AND ITSRELATIONSHIP TO THE SEVERE CLINICALPHENOTYPES, 21th United European Gastroenterology Week, (Berlin, Germany, '13.10).

0320I023(T. Shibata), T. Tahara, J. Yonemura, T. Kawamura, K. Sumi, Y. Ichikawa, M. Okubo, M. Miyata, T. Ishizuka, M.
Nakamura, T. Arisawa, I. Hirata: THE ASSOCIATION OF MUCIN PHENOTYPIC EXPRESSION OF GASTRICCANCER AND SURVIVAL RATE, 21th United European Gastroenterology Week, (Berlin, Germany, '13.10).

－ 34 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Senior Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Assistant Professor

ADACHI Hiroki

Clinical nephrology

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

－ 35 －

Publications
Originals
0330B001(H.Sugiyama), H.Yokoyama, H.Sato, T.Saito, Y.Kohda, S.Nishi, K.Tsuruya, H.Kiyomoto, H.Iida, T.Sasaki,
M.Higuchi, M.Hattori, K.Oka, S.Kagami, T.Kawamura, T.Takeda, H.Hataya, Y.Fukasawa, A.Fukatsu,
K.Morozumi, N.Yoshikawa, A.Shimizu, H.Kitamura, Y.Yuzawa, S.Matsuo, Y.Kiyohara, K.Joh, M.Nagata,
T.Taguchi, H.Makino: Japan Renal Biopsy Registry and Japan Kidney Disease Registry: Committee Report for 2009
and 2010., Clin. Exp. Nephrol., 17:155-173, 2013.

0330B002(K.Furuichi), M.Shimizu, T.Toyama, D.Koya, Y.Koshino, H.Abe, K.Mori, H.Satoh, M.Imanishi, M.Iwano,
H.Yamauchi, E.Kusano, S.Fujimoto, Y.Suzuki, S.Okuda, K.Kitagawa, Y.Iwata, S.Kaneko, S.Nishi, H.Yokoyama,
Y.Ueda, M.Haneda, H.Makino, T.Wada: Japan Diabetic Nephropathy Cohort Study: study design, methods, andimplementation., Clin. Exp. Nephrol., 17:819-826, 2013.

0330B003(S.Shoji), M.Inaba, N.Tomosugi, S.Okuno, M.Ichii, T.Yamakawa, S.Kurihara: Greater potency of darbepoetin-αthan erythropoietin in suppression of serum hepcidin-25 and utilization of iron for erythropoiesis in hemodialysis
patients., Eur. J. Haematol., 90:237-244, 2013.

0330B004(S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura: Inhibition of mTORC2 but not mTORC1
up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell
carcinoma., J. Urol., 189:1921-1929., 2013.

0330B005

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

0330B006(T.Fujiwara), T.Ikeda, Y.Nagasaka, Y.Okitsu, Y.Katsuoka, N.Fukuhara, Y.Onishi, K.Ishizawa, R.Ichinohasama,
N.Tomosugi, H.Harigae: A low-molecular-weight compound K7174 represses hepcidin: possible therapeuticstrategy against anemia of chronic disease., PLoS ONE, 8:e75568;1-13, 2013.

0330B007(SNJ.Song), M.Iwahashi, N.Tomosugi, K.Uno, J.Yamana, S.Yamana, T.Isobe, H.Ito, H.Kawabata, K.Yoshizaki:
Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin,
anemia response and disease activity in rheumatoid arthritis patients., Arthritis Res. Ther., 15:R141;1-10, 2013.

0330B008(M.Shimizu), K.Furuichi, T.Toyama, S.Kitajima, A.Hara, K.Kitagawa, Y.Iwata, N.Sakai, T.Takamura, M.Yoshimura,
H.Yokoyama, S.Kaneko, T.Wada: Long-term outcomes of Japanese type 2 diabetic patients with biopsy-provendiabetic nephropathy, Diabetes Care., 36:3655-3662, 2013.

0330B009

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: The effects of continuing anddiscontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working
population in Japan., Environ. Health Prevent. Med., 18:24-32, 2013.

0330B010

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Distribution of and factors
contributing to chronic kidney disease in a middle-aged working population., Environ. Health Prevent. Med., 18：466-476, 2013.

Reviews
0330C001(T.Wada), M. Shimizu, H.Yokoyama, Y. Iwata, Y. Sakai, S. Kaneko, K. Furuichi: Nodular lesions and mesangiolysis
in diabetic nephropathy., Clin. Exp. Nephrol., 17:3-9, 2013.

0330C007

H.Yokoyama: Epidemiological and clinicopathological studies based on web registration system(J-RBR/J-KDR),
Japanese Journal of Pediatric Nephrology, 26：37-43, 2013 (in Japanese) .

0330C008

H.Adachi, H.Yokoyama : Membranoproliferative glomerulonephritis(MPGN), Kidney and Dialysis, 74:188-191,
2013 (in Japanese) .

－ 36 －

Case Reports
0330D001(M.Oshima), S.Kitajima, T.Toyama, A.Hara, K.Kitagawa, Y.Iwata, M.Shimizu, S.Nishio, J.Imura, H.Yokoyama,
K.Furuichi, S.Kaneko, T.Wada: Successful delivery in a patient with antineutrophil cytoplasmic antibodyassociated glomerulonephritis., Intern. Med., 52:1605-1609, 2013.

0330D002

H.Okuyama, H.Yamaya, T.Fukushima, H.Yokoyama: A patient with persistent renal AL amyloid deposition after
clinical remission by HDM/SCT therapy., Clin. Nephrol., 79:233-236, 2013.

0330D003

S.Nagayama, Y.Gondo, S.Araya, N.Minato, M.Fujita, M.Kaito, M.Nakanishi, K.Tanaka, H.Yamaya, H.Yokoyama,
K.Nakamichi, M.Saijo, K.Okamoto, Y.Toyoshima, A.Kakita, M.Matsui: Progressive multifocal leukoencephalopathy
developed 26 years,after renal transplantation., Clin. Neurol. Neurosurg., 115:1482-1484, 2013.

Others
0330F001

N.Hayashi, H.Okuyama, Y.Matsui, H.Yamaya, E.Kinoshita, H.Minato, Y.Niida, H.Yokoyama: Adult-onset renal
failure in a family with Alagille syndrome with proteinuria and a novel JAG1 mutation., Clin Kidney J, 6:295-299,
2013.

0330F002(T.Suzuki), K.Toba, K.Kato, T.Ozawa, M.Higasimura, T.Kitajima, H.Oda, K.Tsuchida, N.Tomosugi, H.Saitoh,
Y.Aizawa: Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction
who underwent successful percutaneous coronary intervention., Int. J. Cardiol., 167:286-288, 2013.

0330F003(T.Suzuki), K.Toba, K.Kato, T.Ozawa, H.Suzuki, N.Tomosugi, H.Saitoh, Y.Aizawa: Effects of erythropoietin
administration on iron status in patients with ST-elevation myocardial infarction who underwent successful
percutaneous coronary intervention., Int. J. Cardiol., 167:1644-1645, 2013.

Presentations at Conference
International Conference (Presentations)
0330I001

Y.Yamada, Y.Noborisaka, M.Ishizaki, R.Honda, H.Yokoyama, M.Tabata, M.Miyao: Risk factors related to thedevelopment of chronic kidney disease (CKD) in middle-aged workers, 6th ICOH International Conference on
Work Environment and Cardiovascular Disease, (Tokyo, '13.03)，6th ICOH International Conference on Work
Environment and Cardiovascular Disease. Abstract Book, p41, 2013.

0330I002

H.Yokoyama, H.Yamaya, H.Okuyama: Angiotensin II receptor blockers protected renal allografts in Japanese (Subanalysis of I-LORD study), World Congress of Nephrology 2013 Hong-Kong, (Hong-Kong, '13.06).

0330I003

H.Adachi, H.Atsumi, H.Okuyama, H.Yamaya, H.Yokoyama: Renoprotective effects of HDL-C and an adiponectin
paradox in subjects with renal transplantion, WCN 2013 Satellite Symposium Kidney and Lipids, (Fukuoka,'13.06)，WCN 2013 Satellite Symposium Kidney and Lipids Scientific Program and Abstracts, 83, 2013.

0330I004

H.Atsumi, H.Adachi, Y.Chikazawa, H.Okuyama, H.Yamaya, H.Yokoyama: The long-term outcome of Japanese
renal allograft recipients with hepatitis C viral infection, The 13th Congress of the Asian Society ofTransplantation(CAST2013), (Kyoto, '13.09).

0330I005

A.Saito, H.Yokoyama, H.Okuyama, H.Yamaya, I.Ishikawa: Intact PTH and FGF23 levels of cinacalcet pre-test
predict refractory hyperparathyroidism in hemodialysis patients, The Annual of American Society of Nephrology,(Atlanta, '13.11).

0330I006

K.Fujimoto, K.Mukai, Y.Okushi, K.Okino, H.Atsumi, H.Adachi, H.Okuyama, H.Yamaya, H.Yokoyama: Circulating
Soluble Urokinase Receptor Levels in Primary Nephrotic Syndrome Predict the Response to Therapy, The Annualof American Society of Nephrology, (Atlanta, '13.11).

0330I007(T.Wada), M.Nangaku, S.Maruyama, E.Imai, K.Shoji, S.Kato, T.Endo, E.Muso, K.Kamata, H.Yokoyama,
K.Fujimoto, Y.Obata, T.Nishino, H.Kato, S.Uchida, Y.Sasatomi, T.Saito, S.Matuso: Circulating suPAR in Japanesepatients with glomerular diseases:a multicenter cross-sectional study, The Annual of American Society ofNephrology, (Atlanta, '13.11).

0330I008(R.Yamamoto), S.Maruyama, H.Yokoyama, S.Matsuo, E.Imai: Resistance to immunosuppressive therapy in patientswith primary nephrotic syndrome:Japan Nephrotic Syndrome Cohort Study(JNSCS), The Annual of American
Society of Nephrology, (Atlanta, '13.11).

－ 37 －

0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Senior Assistant Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Assistant Professor

ITO Hiroki

diabetes

Assistant Professor

KANASAKI Megumi

diabetes, hypertension, obesity, preeclampsia

Assistant Professor

ASTUMI Hisanari

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Books
0340A011

M. Kitada, D. Koya: The use of calorie restriction mimetics to study aging, Biological Aging: Methods andProtocols Second Edition (Trygve O. Tollefsbol Editor), 95-107, Humana Press, "Alabama, Birmingham, USA",2013.

－ 38 －

Publications
Originals
0340B001(K.Furuichi), M.Shimizu, T.Toyama, D.Koya, Y.Koshino, H.Abe, K.Mori, H.Satoh, M.Imanishi, M.Iwano,
H.Yamauchi, E.Kusano, S.Fujimoto, Y.Suzuki, S.Okuda, K.Kitagawa, Y.Iwata, S.Kaneko, S.Nishi, H.Yokoyama,
Y.Ueda, M.Haneda, H.Makino, T.Wada: Japan Diabetic Nephropathy Cohort Study: study design, methods, andimplementation., Clin. Exp. Nephrol., 17:819-826, 2013.

0340B002(H.Kakuda), K.Kanasaki, D.Koya, N.Takekoshi: The administration of pitavastatin augments creatinine clearance
associated with reduction in oxidative stress parameters: acute and early effects., Clin. Exp. Nephrol., 17:240-247,
2013.

0340B003(K.Ueshima), M.Kasahara, D.Koya, T.Babazono, T.Sato, M.Imamoto, S.Yasuno, A.Fujimoto, S.Tanaka, G.Kimura,
K.Nakao: Effects of atorvastatin on renal function in patients with dyslipidemia and chronic kidney disease:rationale and design of the assessment of clinical usefulness in CKD patients with atorvastatin (ASUCA) trial.,
Clin. Exp. Nephrol., 17:211-217, 2013.

0340B004(N.Takeda), S.Kume, Y.Tanaka, Y.Morita, M.Chin-Kanasaki, H.Araki, K.Isshiki, S.Araki, M.Haneda, D.Koya,
A.Kashiwagi, H.Maegawa, T.Uzu: Altered unfolded protein response is implicated in the age-related exacerbationof proteinuria-induced proximal tubular cell damage., Am. J. Pathol., 183:774-785, 2013.

0340B005(S.Araki), M.Haneda, D.Koya, T.Sugaya, K.Isshiki, S.Kume, A.Kashiwagi, T.Uzu, H.Maegawa: Predictive effects ofurinary liver-type fatty acid-binding protein for deteriorating renal function and incidence of cardiovascular disease
in type 2 diabetic patients without advanced nephropathy., Diabetes Care., 36:1248-1253, 2013.

0340B006

K.Kanasaki, W.Yu, M.von Bondungen, JD.Larigakis, M.Kanasaki, F.Ayala de la Pena, R.Kalluri, WG. Hill: Loss of
β1-integrin from urothelium results in overactive bladder and incontinence in mice: a mechanosensory rather thanstructural phenotype., FASEB J., 27:1950-1961, 2013.

0340B007(V.Plaks), J.Rinkenberger, J.Dai, M.Flannery, M.Sund, K.Kanasaki, W.Ni, R.Kalluri, Z.Werb: Matrix
metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction., Proc.
Natl. Acad. Sci. U.S.A., 110:11109-11114, 2013.

0340B008

M.Nishizawa, H.Nakabayashi, K.Uehara, A.Nakagawa, K.Uchida, D.Koya: Intraportal GLP-1 stimulates insulin
secretion predominantly through the hepatoportal-pancreatic vagal reflex pathways., Am. J. Physiol. Endocrinol.
Metab., 305:E376-E387, 2013.

0340B009

L.Xu, M.Kanasaki, J.He, M.Kitada, K.Nagao, H.Jinzu, Y.Noguchi, H.Maegawa, K.Kanasaki, D.Koya: Ketogenic
essential amino acids replacement diet ameliorated hepatosteatosis with altering autophagy-associated molecules.,Biochim. Biophys. Acta., 1832:1605-1612, 2013.

0340B010

M.Kitada, S.Kume, A.Takeda-Watanabe, S.Tsuda, K.Kanasaki, D.Koya: Calorie restriction in overweight males
ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly
including AMPK and SIRT1 activation., Biochim. Biophys. Acta., 1830:4820-4827, 2013.

0340B011(K.Yamahara), S.Kume, D.Koya, Y.Tanaka, Y.Morita, M.Chin-Kanasaki, H.Araki, K.Isshiki, S.Araki, M.Haneda,
T.Matsusaka, A.Kashiwagi, H.Maegawa, T.Uzu: Obesity-mediated autophagy insufficiency exacerbates
proteinuria-induced tubulointerstitial lesions., J. Am. Soc. Nephrol., 24:1769-1781, 2013.

0340B012(T.Wada), Y.Miyashita, M.Sasaki, Y.Aruga, Y.Nakamura, Y.Ishii, M.Sasahara, K.Kanasaki, M.Kitada, D.Koya,
H.Shimano, H.Tsuneki, T.Sasaoka: Eplerenone ameliorates the phenotypes of metabolic syndrome with NASH inliver-specific SREBP-1c Tg mice fed high-fat and high-fructose diet., Am. J. Physiol. Endocrinol. Metab.,
305:E1415-E1425, 2013.

Reviews
0340C001

M.Kitada, S.Kume, K.Kanasaki, A.Takeda-Watanabe, D.Koya: Sirtuins as possible drug targets in type 2 diabetes.,
Curr. Drug Targets, 14:622-636, 2013.

0340C002(S.Kume), M.Kitada, K.Kanasaki, H.Maegawa, D.Koya: Anti-aging molecule, Sirt1: a novel therapeutic target fordiabetic nephropathy., Arch. Pharm. Res., 36:230-236, 2013.
－ 39 －

0340C003

K.Kanasaki, G.Taduri, D.Koya: Diabetic nephropathy: the role of inflammation in fibroblast activation and kidney
fibrosis., Front Endocrinol (Lausanne), 4:1-15, 2013.

0340C004

M.Kitada, S.Kume, A.Takeda-Watanabe, K.Kanasaki, D.Koya: Sirtuins and renal diseases: relationship with aging
and diabetic nephropathy., Clin Sci (Lond), 124:153-164, 2013.

0340C005

D.Koya, V.M.Campese: Statin use in patients with diabetes and kidney disease: the Japanese experience., J.
Atheroscler. Thromb., 20:407-424, 2013.

0340C006(I.Ohno), H.Hayashi, K.Aonuma, M.Horio, N.Kashihara, H.Okada, Y.Komatsu, S.Tamura, K.Awai, Y.Yamashita,
R.Kuwatsuru, A.Hirayama, Y.Saito, T.Murohara, N.Tamaki, A.Sato, T.Takayama, E.Imai, Y.Yasuda, D.Koya,
Y.Tsubakihara, S.Horie, Y.Korogi, Y.Narumi, K.Hayakawa, H.Daida, K.Node, I.Kubota: Guidelines on the use ofiodinated contrast media in patients with kidney disease 2012 -digest version- JSN, JRS and JCS Joint Working
Group, Circ. J., 77:1883-1914, 2013.

0340C007(I.Ohno), H.Hayashi, K.Aonuma, M.Horio, N.Kashihara, H.Okada, Y.Komatsu, S.Tamura, K.Awai, Y.Yamashita,
R.Kuwatsuru, A.Hirayama, Y.Saito, T.Murohara, N.Tamaki, A.Sato, T.Takayama, E.Imai, Y.Yasuda, D.Koya,
Y.Tsubakihara, S.Horie, Y.Korogi, Y.Narumi, K.Hayakawa, H.Daida, K.Node, I.Kubota: Guidelines on the use ofiodinated contrast media in patients with kidney disease 2012 -digest version- JSN, JRS and JCS Joint Working
Group, Jpn. J. Radiol., 31:546-584, 2013.

0340C008(I.Ohno), H.Hayashi, K.Aonuma, M.Horio, N.Kashihara, H.Okada, Y.Komatsu, S.Tamura, K.Awai, Y.Yamashita,
R.Kuwatsuru, A.Hirayama, Y.Saito, T.Murohara, N.Tamaki, A.Sato, T.Takayama, E.Imai, Y.Yasuda, D.Koya,
Y.Tsubakihara, S.Horie, Y.Korogi, Y.Narumi, K.Hayakawa, H.Daida, K.Node, I.Kubota: Guidelines on the use ofiodinated contrast media in patients with kidney disease 2012 -digest version- JSN, JRS and JCS Joint Working
Group, Clin. Exp. Nephrol., 17:441-479, 2013.

0340C009

SP.Srivastava, D.Koya, K.Kanasaki: MicroRNAs in kidney fibrosis and diabetic nephropathy: roles on EMT and
EndMT., Biomed Res Int., 2013:125469;1-10, 2013.

0340C010

J.He, Y.Xu, D.Koya, K.Kanasaki: Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic
kidney disease., Clin. Exp. Nephrol., 17:488-497, 2013.

0340C011

K.Kanasaki, M.Kanasaki: Angiogenic defects in preeclampsia: what is known, and how are such defects relevant topreeclampsia pathogenesis?, Hypertens. res. pregnancy, 1:57-65, 2013.

0340C012

M.Kitada, D.Koya: Renal protective effects of resveratrol., Oxid. Med. Cell. Longev., 2013:568093;1-7, 2013.

0340C013

M.Kitada, D.Koya: SIRT1 in type 2 diabetes: mechanisms and therapeutic potential., Diabetes Metab J, 37:315325, 2013.

0340C014

K.Kanasaki, M.Kitada, M.Kanasaki, D.Koya: The biological consequence of obesity on the kidney., Nephrol. Dial.
Transplant., 28suppl 4;1-7, 2013.

0340C015(K.Yamahara), M.Yasuda, S.Kume, D.Koya, H.Maegawa, T.Uzu: The role of autophagy in the pathogenesis of
diabetic nephropathy., J Diabetes Res., 2013:193757;1-9, 2013.

Case Reports
0340D001

K.Kanasaki, K.Konishi, R.Hayashi, H.Shiroeda, T.Nomura, A.Nakagawa, T.Nagai, A.Takeda-Watanabe, H.Ito,
S.Tsuda, M.Kitada, M.Fujii, M.Kanasaki, M.Nishizawa, Y.Nakano, Y.Tomita, N.Ueda, T.Kosaka, D.Koya: Three
ileus cases associated with the use of dipeptidyl peptidase-4 inhibitors in diabetic patients., J Diabetes Investig,
4:673-675, 2013.

Short Communications
0340E001(S.Araki), H.Matsuno, M.Haneda, D.Koya, Y.Kanno, S.Kume, K.Isshiki, H.Araki, S.Ugi, H.Kawai, A.Kashiwagi,
T.Uzu, H.Maegawa: Cilostazol attenuates spontaneous microaggregation of platelets in type 2 diabetic patientswith insufficient platelet response to aspirin., Diabetes Care., 36:e92-e93, 2013.

－ 40 －

Others
0340F001(H.Sugimoto), V.S.Lebleu, D.Bosukonda, P.Keck, G.Taduri, W.Bechtel, H.Okada, W.Carlson, P.Bey,
M.Rusckowski, B.Tampe, D.Tampe, K.Kanasaki, M.Zeisberg, R.Kalluri: Reply to regarding the mechanism of actionof a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase3, Nat. Med., 19:810811, 2013.

Presentations at Conference
International Conference (Presentations)
0340I001(Y.Tanaka), S.Kume, S.Maeda, H.Araki, K.Isshiki, S.Araki, I.Oshima, D.Koya, M.Hanada, A.Kashiwagi, T.Uzu,
H.Maegawa: Increased expression of acetyl-CoA carboxylase β is involved in podocyte injury in diabetic
nephropathy, American Diabetes Association 73rd scientific sessions, (Chicago, Illinois, USA, '13.06)，
Diabetes(American diabetes association 73rd scientific sessions final program), 62:(Suppl.1)A131, 2013.

0340I002(K.Yamahara), S.Kume, D.Koya, Y.Tanaka, H.Araki, K.Isshiki, S.Araki, M.Haneda, A.Kashiwagi, T.Uzu,
H.Maegawa: mTORC1-mediated autophagy insufficiency exacerbates proteinuria-induced proximal tubular cell
damage in obese diabetic mice, American Diabetes Association 73rd scientific sessions, (Chicago, Illinois, USA,'13.06)，Diabetes(American diabetes association 73rd scientific sessions final program), 62:(Suppl.1)A136-A137,
2013.

0340I003

K.Kanasaki, M.Kanasaki, D.Koya: Catechol-o-methyltransferase and 2-methoxyestradiol deficiency is associatedwith hepatic steatosis and glucose tolerance defects, American Diabetes Association 73rd scientific sessions,(Chicago, Illinois, USA, '13.06)，Diabetes(American diabetes association 73rd scientific sessions final program),
62:(Suppl.1)A533, 2013.

0340I004

K.Kanasaki, T.Nagai, SP.Srivastava, M.Kitada, M.Kanasaki, D.Koya: Anti-fibrotic peptide AcSDKP restores
diabetes-suppressed microRNA-let-7 cluster and exhibits therapeutic effect on kidney fibrosis in diabetes, The
49th EASD Annual Meeting, (Barcelona， Spain, '13.09)，Diabetologia (The abstract volume 49th EASD annual
meeting), 56:(Suppl.1)S481, 2013.

0340I005

K.Kanasaki, S.Shi, M.Kanasaki, S.Srivastava, D.Koya: Linagliptin-mediated DPP-4 inhibition ameliorates kidney
fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition, American
Society of Nephrology KIDNEY WEEK 2013, (Atlanta,Georgia,USA, '13.11).

－ 41 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Associate Professor

TANAKA Masao

Rheumatology, Immunology

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Senior Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Senior Assistant Professor

OGISO Hideo

Hematology and Immunology

Assistant Professor

MIKI Miyuki

Hematology and Immunology

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

IWAO Haruka

Hematology and Immunology

Assistant Professor

NAKAJIMA Akio

Hematology and Immunology

Assistant Professor

NAKAMURA Takuji

Hematology and Immunology

Assistant Professor

AOKI Shinya

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
Studies of immunological abnormalities and pathophysiology of autoimmune diseases:
1 Effects of chemokines on vascular injury and Th1 response during chronic inflammation.
2 Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases.
3 Analysis of immunological disorder in sphingomyelin knockout mice.
4 Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis.
5 Detection of stem cells in salivary glands and its implication for regenerative medicine.
Studies of hematological malignancies and development of anti-cancer drugs:
1 Analysis of EB-virus proteins and their roles in lymphoproliferative disorders.
2 Molecular biological analysis of drug resistance.
3 Roles of sphingomyelin on apoptosis.
4 Roles of SMS on niche of leukemia stem cells.

－ 42 －

Publications
Originals
0350B001(K.Ito), K.Yamada, I.Mizushima, M.Azumi, H.Fujii, K.Mizotomi, M.Matsumura, K.Hayashi, M.Yamagishi,
H.Umehara, Y.Yamaguchi, M.Nagata, M.Kawano: Henoch-Schönlein purpura nephritis in a patient with IgG4related disease:a possible association., Clin. Nephrol., 79:246-252, 2013.

0350B002(M.Yano), T.Yamamoto, N.Nishimura, T.Gotoh, K.Watanabe, K.Ikeda, Y.Garan, R.Taguchi, K.Node, T.Okazaki,
Y.Oike: Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice., PLoS
ONE, 8:e61380;1-12, 2013.

0350B003(K.Kasahara), M.Kaneda, T.Miki, K.Iida, N.Sekino-Suzuki, I.kawashima, H.Suzuki, M.Shimonaka, M.Arai, Y.OhnoIwashita, S.Kojima, M.Abe, T.Kobayashi, T.Okazaki, M.Souri, A.Ichinose, N.Yamamoto: Clot retraction ismediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts.,
Blood, 122:3340-3348, 2013.

0350B004(L.Dong), Y.Chen, Y.Masaki, T.Okazaki, H.Umehara: Possible mechanisms of lymphoma development in Sjöguren's
syndrome., Curr. Immunol. Rev., 9:13-22, 2013.

0350B005(H.Tsuboi), S.Hagiwara, H.Asashima, H.Umehara, A.Kawakami, H.Nakamura, H.Sano, K.Tsubota, Y.Ogawa,
E.Takamura, I.Satio, H.Inoue, S.Nakamura, M.Moriyama, T.Takeuchi, Y.Tanaka, S.Hirata, T.Mimori, I.Matsumoto,T.Sumida: Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients., Mod.
Rheumatol., 23:219-225, 2013.

0350B006(N.Sugimoto), K.Matsuzaki, H.Ishibashi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki,
J.Sekine, S.Koizumi, A.Yachie, H.Umehara, O.Shido: Upregulation of aquaporin expression in the salivary glands ofheat-acclimated rats., Sci Rep, 3:1763;1-8, 2013.

0350B007

T.Nakamura: Etiological research on IgG4-related disease by transcriptome analysis., J. Kanazawa. Med. Univ.,
38:29-34, 2013 (in Japanese) .

Reviews
0350C001(Y.Chen), W.Sun, R.Gao, Y.Su, H.Umehara, L.Dong, F.Gong: The role of high mobility group box chromosomal
protein 1 in rheumatoid arthritis., Rheumatology (Oxford), 52:1739-1747, 2013.

0350C002(H.Takamatsu), Y.Ogawa, N.Kobayashi, K.Obata, T.Narisawa, K.Nakayama, S.Munemoto, G.Aoki, K.Ohata,
Y.Kumano, J.Ozaki, R.Murata, Y.Kondo, Y.Terasaki, T.Kurokawa, T.Miyamoto, N.Shimizu, T.Fukushima,
A.Yoshida, T.Ueda, T.Yoshida, S.Nakao: Detection of minimal residual disease in patients with multiple myeloma
using clonotype-specific PCR primers designed from DNA extracted from archival bone marrow slides., Exp.
Hematol., 41:894-902, 2013.

Case Reports
0350D001

H.Okuyama, H.Yamaya, T.Fukushima, H.Yokoyama: A patient with persistent renal AL amyloid deposition after
clinical remission by HDM/SCT therapy., Clin. Nephrol., 79:233-236, 2013.

0350D002

Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Japanese variant of multicentirc cattleman's disease associatedwith serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a
distinct clinicopathological entity?, J. Clin. Exp. Hematop., 53:79-85, 2013.

0350D003

S.Nagayama, N.Minato, M.Nakata, M.Kaito, M.Nakanishi, Y.Masaki, K.Tanaka, M.Matui: A case of waldenström
macroglobulinemia initially manifested as consciousness disturbance:Bing-Neel syndrome., Journal of JapaneseCongress on Neurological Emergencies, 25：29-32, 2013 (in Japanese) .

Others－ 43 －

with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a
distinct clinicopathological entity?, J. Clin. Exp. Hematop., 53:79-85, 2013.
0350D003

S.Nagayama, N.Minato, M.Nakata, M.Kaito, M.Nakanishi, Y.Masaki, K.Tanaka, M.Matui: A case of waldenström
macroglobulinemia initially manifested as consciousness disturbance:Bing-Neel syndrome., Journal of JapaneseCongress on Neurological Emergencies, 25：29-32, 2013 (in Japanese) .

0350F001(H.Kawabata), K.Takai, M.Kojima, N.Nakamura, S.Aoki, S.Nakamura, T.Kinoshita, Y.Masaki: Castleman-Kojima
Others

0350F001

0350F002
0350F002

disease(TAFRO Syndrome): A novel systemic inflammatory disease characterized by a constellation of symptoms,
namely, thrombocytopenia,
ascites(Anasarca),
microcytic
anemia, myelofibrosis,
renaldysfunction,
and(H.Kawabata),
K.Takai, M.Kojima,
N.Nakamura,
S.Aoki, S.Nakamura,
T.Kinoshita,
Y.Masaki:Castleman-Kojimaorganomegaly: ASyndrome):
status reportand summary
Fukushima(6disease
June, 2012)
and Nagoya
September,disease(TAFRO
A novelsystemicofinflammatory
characterized
by ameetings(22constellationof symptoms,
2012), J.thrombocytopenia,
Clin. Exp. Hematop.,
53:57-61, 2013.microcytic anemia, myelofibrosis, renal dysfunction, andnamely,ascites(Anasarca),organomegaly: A status report and summary of －Fukushima(6June, 2012) and Nagoya meetings(22 September,
43 －(J.H.Stone), J.K.C.Chan, V.Deshpande, K.Okazaki, H.Umehara, Y.Zen: IgG4-related disease., Int. J. Rheumatol.,2012), J. Clin. Exp. Hematop., 53:57-61, 2013.
2013 (2013), Article ID 532612, 2013.
(J.H.Stone), J.K.C.Chan, V.Deshpande, K.Okazaki, H.Umehara, Y.Zen: IgG4-related disease., Int. J. Rheumatol.,
2013 (2013), Article ID 532612, 2013.

Presentations at Conference
International
Conference (Key Note Lecture)
at Conference
Presentations
0350G001
0350G001
0350G002
0350G002

International(Key
Note Lecture)
T.Okazaki: TheConference
mechanism toovercome
the chemoresistance of leukemia cells through autophagic cell death,International congress Cancer Cell Death and Resistance, (Toulouse, '13.05).
T.Okazaki: The mechanism to overcome the chemoresistance of leukemia cells through autophagic cell death,
T.Okazaki: Regulation of Malignant Cell Proliferation and Migration through SM in Plasma Membrane, International
International congress Cancer Cell Death and Resistance, (Toulouse, '13.05).
Conference of the Korean Society for Molecular and Cellular Biology, (Seoul, '13.10).
T.Okazaki: Regulation of Malignant Cell Proliferation and Migration through SM in Plasma Membrane, International
International
Conference(Synposium)
Conferenceof theKorean Society
for Molecular and Cellular Biology, (Seoul, '13.10).

0350H001

International
Conference (Synposium)
H.Umehara: Oveview and CDC criteria for IgG4-related disease(IgG4-RD), 12th International Symposium on

0350H001
0350H002

Sjögren's Syndrome, (Kyoto, '13.10).
H.Umehara: Oveview and CDC criteria for IgG4-related disease(IgG4-RD), 12th International Symposium on
Y.Masaki: Steroid therapy for IgG4-RD, 12th International Symposium on Sjögren's Syndrome, (Kyoto, '13.10).
Sjögren's Syndrome, (Kyoto, '13.10).

0350H002

International
Conference
Y.Masaki:
Steroidtherapy for(Presentations)
IgG4-RD, 12th International Symposium on Sjögren's Syndrome, (Kyoto, '13.10).

0350I001

International
Conference
M. Taniguchi, K.
Kitatani, Y.(Presentations)
Taguchi, T. Takegami, H. Umehara, T. Okazaki: Sphingosine-1-phosphate lessens

0350I001
0350I002
0350I002
0350I003
0350I003

ceramide-mediated cell death in IL-2 deprived natural killer cells, FASEB Science Research Conference, (Niseko,'13.08).
M. Taniguchi, K. Kitatani, Y. Taguchi, T. Takegami, H. Umehara, T. Okazaki: Sphingosine-1-phosphate lessens
ceramide-mediated cell death in IL-2 deprived natural killer cells, FASEB Science Research Conference, (Niseko,
T.Kawanami, T.Takata, H.Iwao, Y.Masaki, H.Shimizu, T.Sato, T.Nakamura, A.Nakajima, M.Miki, Y.Fujita,'13.08).
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Proteomics analysis in IgG4-related disease, 12th International
Symposium onT.Takata,
Sjögren's H.Iwao,
Syndrome,(Kyoto,H.Shimizu,'13.10). T.Sato, T.Nakamura, A.Nakajima, M.Miki, Y.Fujita,
T.Kawanami,
Y.Masaki,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Proteomics analysis in IgG4-related disease, 12th International
A.Nakajima, Y.Masaki, T.Nakamura, T.Kawanami, H.Shimizu, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita,
Symposium on Sjögren's Syndrome, (Kyoto, '13.10).
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Analysis of CLC and MS4A3 gene expression in perioheral bloodmononuclear Y.Masaki,
cells from T.Nakamura,patients with T.Kawanami,
IgG4-related H.Shimizu,
disease, 12th
Internationalon Sjögren's
Syndrome,
A.Nakajima,
T.Sato,H.Iwao, Symposium
M.Miki, T.Sakai,
Y.Fujita,(Kyoto, '13.10).
M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara: Analysis of CLC and MS4A3 gene expression in perioheral bloodmononuclear cells from patients with IgG4-related disease, 12th International Symposium on Sjögren's Syndrome,(Kyoto, '13.10).

－ 44 －－ 44 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TOMIOKA Ryo

Clinical neurology, Neuroimmunology

Associate Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

FUJITA Michiyo

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(M.Kaito), S.Araya, Y.Gondo, M.Fujita, N.Minato, M.Nakanishi, M.Matsui: Relevance of distinct monocyte subsets
to clinical course of ischemic stroke patients., PLoS ONE, 8:e69409;1-9, 2013.

0360B002(S.Tetsuka), K.Tominaga, E.Ohta, K.Kuroiwa, E.Sakashita, K.Kasashima, T.Hamamoto, M.Namekawa, M.Morita,
S.Natsui, T.Morita, K.Tanaka, Y.Takiyama, I.Nakano, H.Endo: Paraneoplastic cerebellar degeneration associatedwith an onconeural antibody against creatine kinase,brain-type., J. Neurol. Sci., 335:48-57, 2013.

0360B003(H.Sakamoto), M.Hirano, M.Samukawa, S.Ueno, S.Maekura, H.Fujimura, M.Kuwahara, Y.Hamada, C.Isono,
K..Tanaka, S.Kusunoki, Y.Nakamura: Details of trearment-related difficulties in men with Anti-N-Methyl-DAspartate receptor encephalitis., Eur. Neurol., 69:21-26, 2013.

0360B004(K.Park), M.Tahara, K.Tanaka, M.Tanaka: Altitudinal hemianopsia in Japanese patients with NMO or NMO
spectrum disorder., Neurological Medicine, 78:118-121, 2013 (in Japanese) .

Reviews
0360C001

M.Matsui: Novel disease modifying drugs for multiple sclerosis:approach to disease activity free status., Neurol
Therap, 30:109-112, 2013 (in Japanese) .

0360C002

R.Tomioka, K.Tanaka: Stiff-person syndrome and related autoantibodies., Brain and nerve., 65:395-400, 2013 (inJapanese) .

0360C003

M.Matsui, S.Nagayama: Diagnpsis of multiple sclerosis., Japanese Journal of Clinical Medicine, 71:811-816, 2013
(in Japanese) .

－ 45 －

0360C007

M.Matsui: Immunology for understanding the pathogenesis of multiple sclerosis., Clinical Neurology, 53:898-901,
2013 (in Japanese) .

0360C011

K.Takana: Autoimmune encephalitis /Encephalopathy and apheresis., Japanese Journal of Apheresis, 32:191-197,
2013 (in Japanese) .

Case Reports
0360D001(Y.Hachiya), R.MIyata, N.Tanuma, K.Hongoku, K.Tanaka, K.Shimoda, S.Kanda, A.Hoshino, Y.Hanafusa,
S.Kumada, E.Kurihara, M.Hayashi: Autoimmune neurological disorders associated with group-A beta-hemolytic
streptococcal infection., Brain Dev., 35:670-674, 2013.

0360D002

S.Nagayama, Y.Gondo, S.Araya, N.Minato, M.Fujita, M.Kaito, M.Nakanishi, K.Tanaka, H.Yamaya, H.Yokoyama,
K.Nakamichi, M.Saijo, K.Okamoto, Y.Toyoshima, A.Kakita, M.Matsui: Progressive multifocal leukoencephalopathy
developed 26 years,after renal transplantation., Clin. Neurol. Neurosurg., 115:1482-1484, 2013.

0360D003

U.Kawai, M.Fujita, S.Nagayama, K.Tanaka, M.Matsui: Late-onset anti-SRP antibody-positive mypathy with rapidly
progressive dysphagia and respiratory failure., Neurological Medicine, 78:579-581, 2013 (in Japanese) .

0360D004(K.Kawanishi), M.Morita, K.Nakahara, S.Tetsuka, T.Kouki, K.Tominaga, H.Endo, T.Yashiro, K.Tanaka, I.Nakano:
Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody.,
Brain and nerve., 65:1401-1405, 2013 (in Japanese) .

0360D005

S.Nagayama, N.Minato, M.Nakata, M.Kaito, M.Nakanishi, Y.Masaki, K.Tanaka, M.Matui: A case of waldenström
macroglobulinemia initially manifested as consciousness disturbance:Bing-Neel syndrome., Journal of JapaneseCongress on Neurological Emergencies, 25：29-32, 2013 (in Japanese) .

0360D006(K.Park), M.Komori, K.Tanaka, M.Tanaka: MS-like lesions of brain MRI in NMO-related disorder., Neurological
Medicine, 78:477-479, 2013 (in Japanese) .

0360D007(K.Hara), M.Tateyama, N.Suzuki, K.Shibano, K.Tanaka, H.Ishiguro: Sporadic case of non-progressive neurogenic
muscular atrophy localized in both calf muscles., Clinical Neurology, 53:551-554, 2013 (in Japanese) .

Short Communications
0360E001(M.Tanaka), M.Oono, R.Motoyama, K.Tanaka: Longitudinally extensive spinal cord lesion after initiation,and
multiple extensive brain lesions after cessation of fingolimod treatment in a patient with recurrent myelitis andanti-aquaporin4 antibodies., Clin. Exp. Neuroimmunol., 4:239-240, 2013.

0360E002(H.Fujii), S.Kubo, T.Yunoki, K.Sato, K.Takamatsu, K.Tanaka, Y.Takahashi, M.Kuriyama: Glioblastoma withovarian teratoma having N-methy1-D-aspartate receptor(NMDAR)antibody in CSF., Clinical Neurology, 53:712715, 2013 (in Japanese) .

Others0360F001(M.Tanaka), K.Park, K.Tanaka: Reduced fingolimod dosage treatment for patients with multiple sclerosis andlymphopenia or neutropenia., Mult. Scler., 19:1244-1245, 2013.

Presentations at Conference
International Conference (Presentations)
0360I001

K.Tanaka, M.Fujita, Y.Ishigaki, N.Kato, M.Matsui, M.Tanaka, T.Takegami: Effects of the CSF from anti-NMDA
receptor encephalitis patient on the cultured neurons, The American Academy of Neurology's 65th the ANN
Annual Meeting, (SanDiego, '13.03).

0360I002

K.Tanaka, M.Fujita, M.Matsui, T.Takegami: Immunological profiles of the CSF from the anti-NMDA receptor
encephalitis patient., XXI World Congress of Neurology, (Vienna, '13.09).

－ 46 －

0360I003

K.Tanaka, M.Matsui, M.Tanaka: Autoantibodies other than anti-AQP4 antibodies in seronegative NMO patients,
6th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis., (kyoto, '13.11).

0360I004

M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada,
M.Matsui: Intractable Cough May Be Characteristic Symptom of Neuromyelitis Optica, 6th Congress of the PanAsian Committee for Treatment and Research in Multiple Sclerosis., (kyoto, '13.11).

－ 47 －

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0363B001

N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna,
Y.Motoo: Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabinesensitivity., Mol Clin Oncol., 1:100-104, 2013.

0363B002(A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai,
K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto: Aberrant glycogen synthase kinase 3β is involved in pancreaticcancer cell invasion and resistance to therapy., PLoS ONE, 8:e55289;1-12, 2013.

Reviews
0363C001

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

0363C002

J.Yamakawa, J.Moriya, K.Takeuchi, M.Sawada, Y.Motoo, J.Kobayashi: Significance of kampo, japanese traditional
medicine, in the treatment of obesity:basic and clinical evidence., Evid Based Complement Alternat Med,2013,943075;1-8, 2013.

0363C003

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

Case Reports
0363D001

I.Chikazawa, D.Nakai, K.Miyazawa, T.Tanaka, K.Suzuki, K.Sato, Y.Motoo: Neuroendcrine carcinoma of theprostate treated combined modality therapy., Jpn. J. Cancer Clin., 59：99-104, 2013 (in Japanese) .

0363D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo: A case of leg pain associated with lumber spinal canal stenosis inpatient with Parkinson disease treated by yokukansan., Pain and kampo medicine., 23:114-117, 2013 (inJapanese) .

－ 48 －

Others
0363F001(S.Schröder), S.Lee, T,Efferth, Y.Motoo: Acupuncture and herbal medicine for cancer patients., Evid BasedComplement Alternat Med, 2013:313751;1-5, 2013.

Presentations at Conference
International Conference (Presentations)
0363I001

J.Moriya, J.Yamakawa, J.Kobayashi, Y.Motoo: Successful Treatment with Kampo Medicine for Chronic Fatigue
Syndrome: a Case Report, 2nd International symposium for Japanese Kampo Medicine, (London, UK, '13.04).

0363I002

T.Shimasaki, Y.Ishigaki, A.Kitano, T.Takata, T.Arisawa, N.Ueda, T.Kosaka, T.Takegami, Y.Motoo, N.Tomosugi,
T.Minamoto: Glycogen synthase kinase 38 inhibition sensitizes pancreatic cancer to gemcitabine., Digestive
Disease Week 2013, (Orlando, '13.05).

－ 49 －

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

BABA Hisashi

Clinical Infectious Diseases, Infection Control and Prevention,
Clinical Microbiology

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001(K.Fujita), Y.Ito, T.Hirai, K.Maekawa, S.Imai, S.Tatsumi, A.Niimi, Y.Iinuma, S.Ichiyama, M.Mishima: Genetic
relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease andtheir residential soils., Clin. Microbiol. Infect., 19:537-541, 2013.

0366B002

N.Yoshino, Y.Asai, E.Yamada, K.Enda, H.Baba, Y.Iinuma: Fundamental assessment of chemiluminescent
enzyme immunoassay measurement reagent "Lumipulse HBcAb-N", Japanese Journal of Medical Technology,
62:314-318, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0366I001

Y.Iinuma, H.Baba, J.Mitsuyama, N.Nomura, Surveillance Study Group of Antimicrobial Resistance in Hokuriku
District: Multicenter survey of the antibiotic susceptibility of anaerobic gram-negative bacilli in Japan., IDWeek
2013, (San Francisco, '13.10).

0366I002

H.Baba, M.Suzuki, Y.Iinuma, Surveillance Study Group of Antimicrobial Resistance in Hokuriku District: Possible
Spreading of Exfoliative Toxin A-Positive Methicillin-Resistant Staphylococcus aureus (MRSA) in Japan as the
Dominant Clone of Community-Associated MRSA among Children., IDWeek, (San Francisco, '13.10).

－ 50 －

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Associate Professor

AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology

Senior Assistant Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

YAMAKAWA Junichi

General medicine, Kampo medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Assistant Professor

HAYASAKI Hisae

lifestyle-related disease

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Reviews
0368C001(N.Yamaaki), K.Yagi, J.Kobayashi, A.Nohara, N.Ito, A.Asano, K.Nakano, J.Liu, T.Okamoto, Y.Mori, A.Ohbatake,
S.Okazaki, Y.Takeda, M.Yamagishi: Impact of serum retinol-binding protein 4 levels of regulation of remnant-likeparticles triglyceride in type 2 diabetes mellitus., J Diabetes Res., 2013:143515;1-5, 2013.

0368C002

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

0368C003

J.Yamakawa, J.Moriya, K.Takeuchi, M.Sawada, Y.Motoo, J.Kobayashi: Significance of kampo, japanese traditional
medicine, in the treatment of obesity:basic and clinical evidence., Evid Based Complement Alternat Med,2013,943075;1-8, 2013.

0368C004

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

0368C005(K.Miyashita), J.Kobayashi, S.Imamura, N.Kinoshita, KL.Stanhope, PJ.Havel, K.Nakajima, T.Machida, H.Sumino,
M.Nara, M.Murakami: A new enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase.,
Clin. Chim. Acta, 424:201-206, 2013.

0368C006(H.Kakuda), J.Kobayashi, M.Sawada, N.Takekoshi: Short-term effect of pitavastatin treatment on glucose and lipid
metabolism and oxidative stress in fasting and postprandial state using a test meal in japanese men., Cholesterol,
2013:314170;1-7, 2013.

0368C009

J.Kobayashi: Pathogenesis of dyslipidemia:From the view point of enzymes involved in lipoprotein metabolism., J.
Kanazawa. Med. Univ., 38.2:81-89, 2013 (in Japanese) .

－ 51 －

Case Reports
0368D001(K.Takeuchi), M.Kakuyama, T.Isada, R.Saito, S.Shine, J.Moriya, J.Yamakawa: Effect of tokito on the
hypochondralgia resulted from cold constitution., Pain and kampo medicine., 23:107-109, 2013 (in Japanese) .

0368D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo: A case of leg pain associated with lumber spinal canal stenosis inpatient with Parkinson disease treated by yokukansan., Pain and kampo medicine., 23:114-117, 2013 (inJapanese) .

0368D003(K.Takeuchi), J.Moriya, J.Yamakawa: Effectiveness of goshuyuto -on chronic headache in a case of low intracranialpressure syndrome., Journal of kampo medicine., 60:945-951, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0368I001

J.Moriya, J.Yamakawa, J.Kobayashi, Y.Motoo: Successful Treatment with Kampo Medicine for Chronic Fatigue
Syndrome: a Case Report, 2nd International symposium for Japanese Kampo Medicine, (London, UK, '13.04).

－ 52 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor(Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Senior Assistant Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

HIGASHIKAWA
Toshihiro

Geriatrics, Circulation

Assistant Professor

MORITA Takuro

Geriatrics, Circulation

Research Doctor

TAKATA MeikoGeriatrics

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Books
0370A005

M.Okuro, S.Nishino: Narcolepsy, cataplexy, and sleep paralysis, Sleep and movement disorders, 481-495, " Oxford
University Press, Inc.", New York, 2013.

Publications
Originals
0370B001

Y.Koizumi, Y.Hamazaki, M.Okuro, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association between
hypertension status and the screening test for frailty in elderly community-dwelling Japanise, Hypertens. Res.,
36:639-644, 2013.

0370B002(Y.Imai), S.Morimoto, T.Nakahashi, GEANE study group & HOMED-BP study group: Genome-wide response to
antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP
study., Pharmacogenomics, 14:1709-1721, 2013.

－ 53 －

Presentations at Conference
International Conference (Presentations)
0370I001

K.Iwai, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: Oppsite directional regulations of microRNA
expression in arterial smooth muscle cell by HMGA1 and CTCF on the scaffold/matrix-attachment regions, The
77th Annual Scientific Meeting of the Japanese Circulation Society, (Yokohama, '13.03)，Circulation Journal,
77(Suppl. I)：I-1648, 2013.

0370I002

M.Okuro, S.Morimoto: Association of severe hypertension with pneumonia in elderly patients whih acute stage
cerebral infarction., Tne 20th Iagg world congress of gerontology and geriatrics(IAGG2013), (Seoul, '13.06).

0370I003

K.Iwai, T.Morita, O.Iritani, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF and HMGA1 opposite directionallyregulate the gene expression of microRNAs at scaffold/matrix-attachment regions in the arterial smooth muscle
cell, American Heart Association Scientific sessions 2013, (Dallas, '13.11).

－ 54 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITO Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

KOBAYASHI Azusa

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Senior Assistant Professor

FUJIKI Takuma

Pediatric nephrology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

KITAOKA Chika

Pediatric cardiology

Assistant Professor

KOH Giyo

Connective tissue disease

Assistant Professor

YAMASHITA Yoko

Pediatric allergy, Pediatric immunology.

Assistant Professor

OGURI Masato

Pediatric cardiology.

Research Doctor

KITO Toshiyuki

Pediatric allergy, Pediatric immunology

Research Doctor

YAMAMOTO Akiko

Child neurology

Research Doctor

FUJII Kunihiro

Pediatric Hematology, Inherited Metabolic Disease

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism
Neonatology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B003

T.Nakamura, Y.Adachi, G.Murakami, A.Yachie, Y.Ohshima, M.Mayumi: Use of pediatric asthma support system to
implement childhood asthma guideline., Japanese journal of pediatrics., 66:1079-1090, 2013 (in Japanese) .

0380B004

T.Kuwahara, M.Kohno, S.Takahashi, Y.Yasui, T.Oshikiri, M.Ito, Y.Saikawa: Determination a relevant period of thepreventive gonadal resection in Y-chromosome-related disorders of sex development(DSD)., Journal of theJapanese Society of Pediatric Surgery., 49:969-974, 2013 (in Japanese) .
－ 55 －

Presentations at Conference
International Conference (Presentations)
0380I001(Ny.Tang), T.Nakamura, M.Takahashi, Jc.Wood: :Abnormal Carotid Artery Dynamics and Endothelial Function in
Pre-Pubertal Obese Children With Normal Echocardiograms, 24th Annual Conference of the Western Society ofPediatric Cardiology, (Monterey, '13.06).

0380I002(Ny.Tang), T.Nakamura, M.Takahashi, Jc.Wood: Abnormal Carotid Artery Dynamics and Endothelial Function in
Pre-Pubertal Obese Children With Normal Echocardiograms, American Academy of Pediatrics National Conference
and Exhibition, ( Florida, '13.10).

－ 56 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Senior Assistant Professor

MONKAWA Akikazu

Brain imaging, Schizophrenia

Senior Assistant Professor

MONKAWA Tomomi

Psychopharmacology, Neuropsychology

Assistant Professor

KOSEKI Yojyu

Brain imaging

Assistant Professor

SHOU Masaya

Psychopharmacology

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Assistant Professor

NITTA Yusuke

Consultation liaison psychiatry

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001(Y.Higuchi), T.Sumiyoshi, T.Seo, T.Miyanishi, Y.Kawasaki, M.Suzuki: Mismatch negativity and cognitive
performance for the prediction of psychosis in subjects with at-risk mental state., PLoS ONE, 8:e54080;1-10,
2013.

0390B002(T.Takahashi), Y.Nakamura, K.Nakamura, E.Ikeda, A.Furuichi, M.Kido, Y.Kawasaki, K.Noguchi, H.Seto, M,Suzuki:
Altered depth of the olfactory sulcus in first-episode schizophrenia., Prog. Neuropsychopharmacol. Biol.
Psychiatry, 40:167-172, 2013.

0390B003(T.Takahashi), K.Nakamura, S.Nishiyama, A.Furuichi, E.Ikeda, M.Kido, Y.Nakamura, Y.Kawasaki, K.Noguchi,
H.Seto, M.Suzuki: Increased pituitary volume in subjects at risk for psychosis and patients with first-episodeschizophrenia., Psychiatry Clin. Neurosci., 67:540-548, 2013.

－ 57 －

0390B004

Y.Nitta: Frontal lobe activations during design fluency test in patients with schizophrenia:a multi-channel nearinfrared spectroscopy study., J. Kanazawa. Med. Univ., 38:64-71, 2013 (in Japanese) .

Short Communications
0390E001(T.Takahashi), K.Nakamura, E.Ikeda, A.Furuichi, M.Kido, Y.Nakamura, Y.Kawasaki, K.Noguchi, H.Seto, M.Suzuki:
Longitudinal MRI study of the midline brain regions in first-episode schizophrenia., Psychiatry Res., 212:150-153,
2013.

Others
0390F001

T.Terai, R.Hashimoto, Y.Nitta, T.Monkawa, Y.Kawasaki, K.Kagechika: Effect of "individual placement andsupport"with psychoeducational approach for schizophrenics., Proceeding of the 7th World Congress of theInternational Society of Physical and Rehabilitation Medicine, 212-214, 2013.

Presentations at Conference
International Conference (Presentations)
0390I001

Y.Matsuda, T.Shimada, Y.Kawasaki: Local cortical gyrification of the insula in schizophrenia:Statisticalcharacteristics and its visualization., 11th World Congress of Biological Psychiatry, (Kyoto Japan, '13.06).

0390I002

T.Shimada, Y.Matsuda, A.Monkawa, R.Hashimoto, H.Kihara, K.Watanabe, Y.Kawasaki: Relationship between thebrain structure function and social functioning in the patients with schizophrenia, 11th World Congress ofBiological Psychiatry, (Kyoto Japan, '13.06).

0390I003(R.Tagawa), H.Hashimoto, A.Nakanishi, Y.Kawarada, T.Muramatsu, Y.Matsuda, S.Higashiyama, J.Kawabe, T.Kai,
K.Inoue: The relationship between medial temporal lobe atrophy and cognitive impairment in patients withdementia with lewy bodies, 11th World Congress of Biological Psychiatry, (Kyoto Japan, '13.06).

0390I004(Y.Tatebayashi), N.Kikuchi, Y.Hayashi, T.Itou, T.Shinozaki, Y.Matsuda: Abnormal fatty acid composition in thefron-topolar cortex of patients with mood disorders, 11th World Congress of Biological Psychiatry, (Kyoto Japan,'13.06).

0390I005(T.Takahashi), K.Nakamura, E.Ikeda, A.Furuichi, M.Kido, Y.Kawasaki, K.Noguchi, H.Seto, M.Suzuki: Altereddepth of the olfactory sulcus in first-episode schizophrenia, 11th World Congress of Biological Psychiatry, (Kyoto
Japan, '13.06).

0390I006(Y.Higuchi), T.Sumiyoshi, T.Seo, T.Miyanishi, Y.Kawasaki, M.Suzuki: Mismatch negativity and cognitive
performance for the prediction of psychosis in subjects with at-risk mental state, 11th World Congress ofBiological Psychiatry, (Kyoto Japan, '13.06).

0390I007

Y.Kawasaki, R.Hashimoto, S.Ono, T.Shimada, H.Kihara, Y.Matsuda, M.Tunoda: Early detection and intervention
project for young people at risk for developing psychosis Uchinada, 21st World Congress Social Psychitry,(Lisbon,Portugal, '13.07).

0390I008

Y.Matsuda, T.Shimada, T.Monkawa, A.Monkawa, K.Watanabe, Y.Kawasaki: Curvature of the temporal pole inpatients with schizophrenia: Statistical characteristics and its visualization., International Conference on Basic andClinical Multimodal Imaging, (Geneva,Switzerland, '13.09).

0390I009

T.Shimada, Y.Matsuda, R.Hashimoto, T.Monkawa, A.Monkawa, K.Watanabe, Y.Kawasaki: Relationship between
the brain structure and social functioning in the patients with schizophrenia, International Conference on Basic andClinical Multimodal Imaging, (Geneva, Switzerland, '13.09).

0390I010

R.Hashimoto, Y.Matsuda, M.Kawahara, F.Kitamoto, Y.Kawasaki: Usability of Self-Other Focused Thinking Error
Scale(SOFT)for clinical patients, 43rd Annual Congress European Association for Behavioural and Cognitive
Therapies., (Marrakech,Morocco, '13.09).

－ 58 －

0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

WATANABE Naoto

Nuclear Medicine

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

Associate Professor

TANIGUCHI Mitsuru

Cardiac Nuclear Medicine

Assistant Professor

KITADATE Masataka Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

KOMINAMI Yoshiki

Diagnostic Imaging

Assistant Professor

TSUCHIYA Naoko

Diagnostic Imaging

Assistant Professor

OTA Kiyotaka

Radiation Therapy

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

H.Shiga, J.Taki, K.Washiyama, J.Yamamoto, S.Kinase, K.Okuda, S.Kinuya, N.Watanabe, H.Tonami, K.Koshida,
R.Amano, M.Furukawa, T.Miwa: Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201
administration in patients with olfactory impairments in comparison to healthy volunteers., PLoS ONE,
8:e57671;1-8, 2013.

0400B002

K.Usuda, Xi.Zhao, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma:
Diffusion-weighted imaging(DWI)signal intensity and distribution represent the amount of cancer cells and theirdistribution in primary lung cancer., Clin. Imaging, 37:265-272, 2013.

0400B003

M.Kitadate, T.Shibamoto, M.Tsutsumi, H.Tonami: Portal venular constriction during anaphylactic shock inanesthetized rats., Biomed. Res., 34:61-68, 2013.
－ 59 －

0400B004

M.Doai, N.Watanabe, T.Takahashi, M.Taniguchi, H.Tonami, K.Iwabuchi, D.Kayano, M.Fukuoka, S.Kinuya:
Sensitive immunodetection of radiotoxicity after iodine-131therapy for thyroid cancer using γ-H2AX foci of
DNA damage in lymphocytes., Ann. Nucl. Med., 27:233-238, 2013.

0400B005

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantage of diffusion-weighted imaging over positron emission tomography-computed in assessment ofhilar and mediastinal lymph node in lung cancer., Ann. Surg. Oncol., 20:1676-1683, 2013.

0400B006

I.Toyota, M.Tanida, T.Shibamoto, Mofei Wang, Y.Kurata, H.Tonami: MRI Reveals edema in larynx (But not inbrain) during anaphylactic hypotension in anesthetized rats., Allergy Asthma Immunol Res., 5:389-396, 2013.

0400B007

Y.Sasagawa, O.Tachibana, M.Doai, T.Akai, H.Tonami, H.Iizuka: Internal carotid arterial shift after transsphenoidal
surgery in pituitary adenomas with cavernous sinus invasion., Pituitary., 16:465-70, 2013.

Presentations at Conference
International Conference (Presentations)
0400I001

Y.Sasagawa, O.Tachibana, M.Doai, T.Akai, H.Tonami, H.Iizuka: Internal carotid arterial shift after transsphenoidal
surgery in pituitary adenomas with cavernous sinus invasion, 37th European Society of Neuroradiology Annual
Meeting, (Frankfurt, Germany, '13.09).

0400I002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography inassessment of hilar and mediastinal lymph node in lung cancer, 18th world cangress on advances in oncology,(Athens, '13.10).

－ 60 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery

Professor

KAWAHIRA Yoichi

Cardiovascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Senior Assistant Professor

KOBATA Takashi

Vascular surgery

Senior Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Assistant Professor

MIKAMI Naofusa

Cardiovascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of patient-specific cardiac supporting net for dilated heart failure patients
3.Endovascular stent-grafting for aortic aneurysm

Publications
Case Reports
0410D001

F.Mizuno, T.Akita, K.Morioka, N.Mikami, Y.Noguchi, T.Kobata, H.Shikata: A case of cardiac angiosarcoma withsuperior vena cava syndrome., The Japanese Society for Cardiovascular Surgery., 42:395-398, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0410I001

K.Okada, T.Akita, K.Morioka, F.Mizuno, N.Mikami: The diastolic function of the right ventricle is more
susceptible than that of the left ventricle by cardiac supporrting device in congestive heart failure, The 21st
Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery, (Kobe, '13.04).

0410I002

T.Akita, M.Seto, T.Suzuki, M.Yamabe: The Patient-Specific Cardiac Support Device for Dilated Heart Failure
Patients, American Society for Artificial Internal Organ Annual Conference, (Minneapolis, '13.06).

－ 61 －

0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Professor

USUDA Katsuo

Assistant Professor

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Facultythoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy－ 62 －

Publications
Originals
0415B001

K.Usuda, Xi.Zhao, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma:
Diffusion-weighted imaging(DWI)signal intensity and distribution represent the amount of cancer cells and theirdistribution in primary lung cancer., Clin. Imaging, 37:265-272, 2013.

0415B002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantage of diffusion-weighted imaging over positron emission tomography-computed in assessment ofhilar and mediastinal lymph node in lung cancer., Ann. Surg. Oncol., 20:1676-1683, 2013.

0415B003

M.Sagwa, J.Shibuya, S.Takahashi, C.Endo, M.Abiko, H.Suzuki, Y.Matsumura, T.Sakuma, N.Sato, H.Deguchi,
Y.Nakayama, T.Hasumi, T.Kondo: A randomized phase Ⅲ trial of postoperative adjuvant therapy for completely
resected stage ＩA-ⅢA lung cancer using an anti-angiogenetic agent: irsogladine maleate., Minerva Chir, 68:587597, 2013.

0415B004

M.Ueno, M.Sagawa, M.Tanaka, Y.Machida, N.Motono, K.Usuda, T.Sakuma: Significance of the perioperative
measurement of brain natriuretic peptide(BNP) in general thoracic surgery., The Journal of the Japanese
Association for Chest Surgery., 27:3-10, 2013 (in Japanese) .

0415B005(T.Kobayashi), T.Matsunaga, K.Ikeda, Y.Kibe, T.Hiura, H.Tanaka, H.Kobayashi, I.Kanetsuki, T.Akutsu, C.Endo,
Y.Takeda, T.Shibayama, K.Nishii, K.Eguchi, M.Sagawa: Evaluation of the consistency of the judgment to low-dose
CT lung cancer screening in many areas., The Journal of the Japanese Society of CT Screening, 20:108-114, 2013
(in Japanese) .

0415B006

N.Motono, M.Ueno, M.Tanaka, Y.Machida, K.Usuda, M.Sagawa, T.Sakuma: Prognostic significance of theperioperative serum carcinoembryonic antigen level for resected non-small cell lung cancer patients., The
Hokuriku journal of surgery., 32:1-4, 2013 (in Japanese) .

Reviews
0415C001

M.Sagawa, T.Nakayama, T.Sobue, K.Eguchi, C.Endo, K.Nshii, T.Kondo: Revision of the criteria for interpretingchest X-ray findings in mass screening for lung cancer(1):categories D and E., Proceedings of the Japanese Lung
Cancer Society Lung cancer., 53:309-313, 2013 (in Japanese) .

0415C002

M.Sagawa, T.Nakayama, T.Sobue, C.Endo, C.Konaka, K.Murata, T.Kobayashi, T.Kondo: Revision of the criteria
for interpreting chest X-ray findings in mass screening for lung cancer(2):categories B,C and D., Proceedings of
the Japanese Lung Cancer Society Lung cancer., 53:314-317, 2013 (in Japanese) .

Case Reports
0415D001

Y.Machida, M.Tanaka, M.Ueno, N.Motono, K.Usuda, M.Sagawa, T.Sakuma: Video-assisted thoracic surgery for
spontaneous pneumothorax using a SILS port, A case report, J. Kanazawa. Med. Univ., 38:150-152, 2013.

0415D002(H.Kitade), T.Yamada, S.Igarashi, K.Hokkoku, M.Mori, K.Shintaku, M.Sagawa, M.Nakai, S.Yano: Efficacy of lowdose erlotinib against gefitinib-induced hepatotoxicity in a patient with lung adenocarcinoma harboring EGFR
mutations., Cancer & chemotherapy, 40:79-81, 2013 (in Japanese) .

0415D003

N.Motono, M.Ueno, Y.Machida, K.Usuda, M.Sagawa, T.Sakuma: A multilocular thymic cyst with thymoma that wasdifficult to diagnose preoperatively., The Journal of the Japanese Association for Chest Surgery., 27:97-102, 2013
(in Japanese) .

0415D004

N.Motono, M.Tanaka, Y.Machida, K.Usuda, M.Sagawa, T.Sakuma: A case of lung cancer with a cavity in which
diffusion-weighted magnetic resonance imaging was useful., The Journal of the Japanese Association for Chest
Surgery., 27:92-96, 2013 (in Japanese) .

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Presentations at Conference
International Conference (Presentations)
0415I001

M.Tanaka, M.Sagawa, Y.Machida, M.Ueno, N.Motono, K.Usuda, T.Sakuma: A randomized trial comparing single
and double chest tube application after pulmonary lobectomy, European resporatory society ERS annual congress
2013, (Barcelona, '13.09).

0415I002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography inassessment of hilar and mediastinal lymph node in lung cancer, 18th world cangress on advances in oncology,(Athens, '13.10).

－ 64 －

0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Senior Assistant Professor

FUJITA Hideto

Surgical treatment of gastric cancer,

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Assistant Professor

MORIOKA Emi

Surgery of Digestive Diseases

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Publications
Originals
0420B001

Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, K.Shimada, Y.Yamamoto, S.Kawakami: Nipple- or skin-sparing
mastectomy and immediate breast reconstraction by the "moving window" operation, Breast Cancer., 20:54-61,
2013.

0420B002

H.Funaki, J.Fujita, E.Morioka, D.Kaida, T.Ohnishi, Y.Ohno, Y.Tomita, M.Noguchi, H.Fujita, S.Kinami, Y.Nakano,N.Ueda, T.Kosaka: Evaluation of conversion gastrectomy for treatment of stage Ⅳ advanced gastric cancer.,Cancer & chemotherapy, 40:1615-1617, 2013 (in Japanese) .

－ 65 －

Reviews
0420C001

M.Noguchi, E.Morioka, Y.Ohno, M.Noguchi, Y.Nakano, T.Kosaka: The changing role of axillary lymph nodedissection for breast cancer., Breast Cancer., 20:41-46, 2013.

Case Reports
0420D001

T.Ohnishi, S.Kinami, J.Fujita, E.Morioka, D.Kaida, Y.Ohno, Y.Tomita, M.Noguchi, H.Funaki, H.Fujita, Y.Nakano,N.Ueda, T.Kosaka: A Case of jejnal cancer who was controlled peritoneal metastasis, successfully by conbination
therapy with docetaxel and S-1., Cancer & chemotherapy, 40:1717-1719, 2013 (in Japanese) .

0420D002

N.Ueda, J.Fujita, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, M.Noguchi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano,
T.Kosaka, H.Minato, H.Takamura: Surgical resection of multiple liver metastases of rectal neuroendocrine tumors.,
Cancer & chemotherapy, 40:1840-1842, 2013 (in Japanese) .

0420D003

Y.Fujii, S.Kinami, N.Ueda, S.Kurosawa, M.Oda, J.Fujita, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, M.Noguchi,
H.Funaki, H.Fujita, Y.Nakano, T.Kosaka: A case report of early duodenal carcinoma coexisting with brunner's
gland hyperplasia., The Hokuriku journal of surgery., 32:21-23, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0420I001

T.Shimasaki, Y.Ishigaki, A.Kitano, T.Takata, T.Arisawa, N.Ueda, T.Kosaka, T.Takegami, Y.Motoo, N.Tomosugi,
T.Minamoto: Glycogen synthase kinase 38 inhibition sensitizes pancreatic cancer to gemcitabine., Digestive
Disease Week 2013, (Orlando, '13.05).

0420I002

S.Kinami, T.Ohnishi, E.Morioka, D.Kaida, Y.Ohno, Y.Tomita, M.Noguchi, H.Funaki, H.Fujita, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: The optimal setting of the ICG fluorescent imaging for sentinel node biopsy of early gastriccancer., Joint international oncology (Sentinel Node & Cancer Metastasis) congress, (San Francisco, '13.05).

0420I003

M.Noguchi-Yokoi, M.Noguchi, Y.Nakano, E.Morioka, Y.Ohno, T.Kosaka: Axillary reverse mapping during sentinel
lymph node biopsy in breast cancer., Joint international Sentinel node & cancer metastasis) congress, (SanFrancisco, '13.05).

0420I004

E.Morioka, S.Kinami, D.Kaida, Y.Ono, T.Onishi, Y.Tomita, M.Noguchi, H.Funaki, H.Fujita, K.Omote, Y.Nakano,N.Ueda, T.Kosaka, M.Noguchi: The occurrence of false negative cases and the measures in the sentinel nodebiopsy for breast cancer, The Internationall College of Surgeons The 59th Annual Congress of Japan Section,(Izumo, '13.06)，Proceedings of The Internationall College of Surgeons The 59th Annual Congress of Japan
Section, 79, 2013.

0420I005

H.Funaki, D.Kaida, T.Onishi, S.Kinami, T.Kosaka: Clinicopathological study of sievert type II carcinoma of theesophagogastric junction from the aspect of recurrence after curative surgery, 10th International gastric cancer
congress, (Verona, '13.06)，10th International gastric cancer congress abstract book, 93, 2013.

0420I006

S.Kinami, T.Onishi, E.Morioka, D.Kaida, Y.Ono, Y.Tomita, M.Noguchi, H.Funaki, H.Fujita, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: ICG fluorescent imaging for sentinel node biopsy of early gastric cancer - A promisingprocedure for laparoscopic surgery., 10th International gastric cancer congress, (Verona, '13.06)，10th
International gastric cancer congress abstract book, 130, 2013.

0420I007

D.Kaida, S.Kinami, T.Onishi, Y.Tomita, H.Funaki, H.Fujita, K.Omote, Y.Nakano, N.Ueda, T.Kosaka: A case of
the gastric tube cancer who was reconstructed using the free jejunal autograft after the local resection of gastrictube., 10th International gastric cancer congress, (Verona, '13.06)，10th International gastric cancer congress
abstract book, 159, 2013.

0420I008(T.Fujimura), Y.Higashi, Y.Yamazaki, T.Tsukada, K.Okamoto, K.Nakamura, K.Oyama, H.Nakagawara,
T.Miyashita, H.Tajima, H.Takamura, I.Ninomiya, H.Kitagawa, S.Fushida, T.Ohta, S.Kinami: Metastasis-positive
patients in sentinel node navigation surgery for early gastric cancer, 10th International gastric cancer congress,(Verona, '13.06)，10th International gastric cancer congress abstract book, 21, 2013.
－ 66 －

0420I009(M.Takahashi), M.Terashima, H.Kawahira, E.Nagai, Y.Uenosono, S.Kinami, Y.Nagata, M.Yoshida, K.Aoyagi,
K.Nakata: Significance of preserving proximal stomach for postperative gastric cancer patients assessed by thepatient reported outcome (PGSAS-45）, 10th International gastric cancer congress, (Verona, '13.06)，10th
International gastric cancer congress abstract book, 48, 2013.

0420I010(N.Fukushima), Y.Kodera, N.Hiki, S.Kinami, M.Yoshida, K.Aoyagi, H.Hata, H.Noro, K.Nakada, J.P.S.Working
Party: Analysis of postoperative QOL using new assessment scale (PGSAS-45) for reconstraction methods after
proximal gastrectomy, 10th International gastric cancer congress, (Verona, '13.06)，10th International gastriccancer congress abstract book, 120, 2013.

0420I011(T.Namikawa), N.Hiki, S.Kinami, H.Okabe, T.Urushihara, H.Kawahira, Y.Kodera, T.Yumiba, K.Nakada: The
factors for minimizing the postgastrectomy symptoms in performing pylorus-preserving gastrectomy, assessed using
PGSAS-45, 10th International gastric cancer congress, (Verona, '13.06)，10th International gastric cancer
congress abstract book, 122, 2013.

－ 67 －

0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Professor

KAWAHARA Norio

Spinal surgery

Professor(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

Associate Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Associate Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

OKUDA Tetsuhito

Spinal surgery

Senior Assistant Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Senior Assistant Professor

FUKUI Kiyokazu

Hip surgery

Senior Assistant Professor

HIROMURA Kentaro

TraumaAssistant Professor

HATANO Eijyu

Spinal surgery

Assistant Professor

YASUDA Yoshihito

Spinal surgery

Assistant Professor

KITAMURA Kenji

Hip surgery

Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

MIKAMI Tomoaki

Hip surgery

Assistant Professor

NAKAGAWA Shintaro Hip surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Assistant Professor

TAKAHASHI Eiji

Hip surgery

Assistant Professor

ORITA Yugo

orthopaedic surgery

Assistant Professor

TAGUCHI Keita

orthopaedic surgery

Research Doctor

KANEKO Seiji

Hip surgery

Research Doctor

SOMA Daisuke

orthopaedic surgery

Research Doctor

MIYAUCHI Yukitaka

orthopaedic surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, spinal cord injury

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
－ 68 －

Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal
cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4
is a digestive enzyme of CSPG . In future, we will clarify the mechanism.

Publications
Originals
0430B001(H.Akiyama), K.Yamamoto, A.Kaneuji, T.Matsumoto, T.Nakamura: In-vitro characteristics of cemented titanium
femoral stems with a smooth surface finish., J. Orthop. Sci., 18:29-37, 2013.

0430B002

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: How far above the true anatomic position can theacetabular cup be placed in total hip arthroplasty?, Hip Int., 23:129-134, 2013.

0430B003(W.Fukushima), T.Yamamoto, S.Takahashi, M.Sakaguchi, Y.Kubo, Y.Iwamoto, Y.Hirota, (Idiopathic ONFH
Multicenter Case-Control Study Group), S.Jingushi, T.Nish.i, N.Sugano, K.Sakai, K.Ohzono, A.Kaneuji,
T.Matsumoto, H.Horiuchi, SKobayashi, M.Kawasaki, Y.Hasegawa, T.Teranishi, T.Matsuno, K.Takaoka, M.Fujioka:
The effect of alcohol intake and the use of oral corticosteroids on the risk of idiopathic osteonecrosis of the femoral
head: a case-control study in Japan., Bone Joint J., 95B:320-325, 2013.

0430B004(S.Demura), H.Murakami, N.Kawahara, S.Kato, K.Yoshioka, H.Tsuchiya: Laminoplasty and pedicle screw fixation
for cervical myelopathy associated with athetoid cerebral palsy: minimum 5-year follow-up., Spine, 38:1764-1769,
2013.

0430B005

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Wear comparison between conventional and highly
cross-linked polyethylene against a zirconia head: a concise follow-up, at an average 10 years, of a previous
report., J. Arthroplasty., 28:1654-1658, 2013.

0430B006(K.Yoshioka), H.Murakami, S.Demura, S.Kato, N.Kawahara, K.Tomita, H.Tsuchiya: Clinical outcome of spinal
reconstruction after total en bloc spondylectomy at 3 or more levels., Spine, 38:E1511-1516, 2013.

0430B007(S.Kato), H.Murakami, S.Demura, K.Yoshioka, T.Ota, K.Shinmura, N.Yokogawa, N.Kawahara, K.Tomita,
H.Tsuchiya: Patient and family satisfaction with en bloc total resection as a treatment for solitary spinal
metastasis., Orthopedics., 36:e1424-e1430, 2013.

0430B008

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto: Cementless anatomic total hip femoral
component with circumferential porous coating for hips with developmental dysplasia: a minimum ten-year followup period., J. Arthroplasty., 28:1746-1750, 2013.

0430B009(K.So), A.Kaneuji, T.Matsumoto, S.Matsuda,, H.Akiyama: Is the bone-bonding ability of a cementless total hip
prosthesis enhanced by alkaline and heat teatments?, Clin. Orthop., 471:3847-3855, 2013.

0430B010

A.Kaneuji, J.Tomidokoro, K.Hirosaki, M.Takano, H.Iwaki, T.Matsumoto: Continuous movement of stems andcement in both polished and rough tapered femoral stems in a biomechanical model., GJMR, 13:9-16, 2013.

0430B011

T.Sugimori, K.Kitamura, A.Kaneuji, T.Matsumoto: Improved accuracy of femoral component alignment by a hip
center marking technique in comparison with conventional implantation in total knee arthroplasty., ClinicalOrthopaedic Surgery, 48:301-307, 2013 (in Japanese) .

0430B012

E.Takahashi: Relationship between bone cement thickness and cement creep: A study using collarless polishedtapered stem., J. Kanazawa. Med. Univ., 38:1-8, 2013 (in Japanese) .

0430B013

S.Kaneko: Early stage ischemia inside the bone in a rat osteonecrosis model., J. Kanazawa. Med. Univ., 38:35-42,
2013 (in Japanese) .

0430B020(S.Kato), H.Murakami, S.Demura, K.Yoshioka, T.Ota, K.Shinmura, N.Yokogawa, X.Fang, N.Kawahara, K.Tomita,
H.Tsuchiya: More than 10-year follow-up after total en bloc spondylectomy for spinal tumors., J Spine Res.,
4:1446-1451, 2013 (in Japanese) .

0430B021(K.Yoshioka), H.Murakami, S.Demura, S.Kato, T.Ota, K.Shinmura, N.Yokogawa, N.Kawahara, K.Tomita,
H.Tsuchiya: Clinical outcome of total en bloc spondylectomy at three or more levels., J Spine Res., 4:1452-1456,
2013 (in Japanese) .
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Reviews
0430C001

A.Kaneuji, K.Fukui, T.Matsumoto: Total hip arthroplasty for osteoarthritis secondary to developmental dysplasiaof the hip -The concept and practice of the placement of cementless acetabular components-, Japanese Journal of
Joint Diseases, 32:103-111, 2013 (in Japanese) .

Case Reports
0430D001

K.Fukui, A.Kaneuji, S.Amaya, T.Matsumoto: Synovial osteochondromatosis of the hip with femoroacetabular
impingement and osteoarthritis: a case report., J. Orthop. Surg. (Hong Kong), 21:117-121, 2013.

0430D002

K.Fukui, A.Kaneuji, E.Kinoshita, Y.Numata, T.Nojima, T.Matsumoto: Localized pigmented villonodular synovitis of
the hip: sudden-onset pain caused by torsion of the tumor pedicle., Case Rep Orthop., 2013:862935;1-4, 2013.

0430D003(S.Kato), H.Murakami, A.Takeuchi, S.Demura, K.Yoshioka, N.Kawahara, K.Tomita, H.Tsuchiya: Fifteen-year
survivor of renal cell carcinoma after metastasectomies for multiple bone metastases., Orthopedics., 36:e14541457, 2013.

0430D004(K.Yoshioka), H.Murakami, S.Demura, S.Kato, Y.Fujimaki, N.Kawahara, K.Tomita, H.Tsuchiya: Spinal metastasisof a subcutaneous sacrococcygeal ependymoma and long-term follow-up. case report., Clinical Orthopaedic
Surgery, 48:529-534, 2013 (in Japanese) .

Others
0430F001

A.Kobe, T.Muratani, M.Kawahara, C.Tsuji, S.Yokogawa, K.Ushiyama, H.Maeda, K.Kagechika, A.Kaneuji, Y.Ohno:
Changes of peak torque and time and knee angle to peak torque for knee extensor and flexor after total hip
arthroplasty, Proceeding of the 7th World Congress of the International Society of Physical and Rehabilitation
Medicine, 210-211, 2013.

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

N.Kawahara: Case presentations for monomultilevel cervical sarcomas : results by management by en bloc excision,
3rd CHARITE SPINE TUMOR DAYS, (Berlin, '13.05).

0430G002

N.Kawahara: Construct breakdown following complex reconstructions: what to do?, 3rd CHARITE SPINE TUMORDAYS, (Berlin, '13.05).

0430G003

N.Kawahara: Total en-bloc spondylectomy for vertebral metastasis, AOSpine Advances Symposium in Vertebral
Tumor & Inflammatory Spinal Disoder Management, (Hong Kong, '13.10).

0430G004

N.Kawahara: Assessment & management of primary malignant vertebral tumor, AOSpine Advances Symposium in
Vertebral Tumor & Inflammatory Spinal Disoder Management, (Hong Kong, '13.10).

0430G005

N.Kawahara: Cervical tumor management, AOSpine Advances Symposium in Vertebral Tumor & Inflammatory
Spinal Disoder Management, (Hong Kong, '13.10).

International Conference (Presentations)
0430I001

M.Kawaguchi, N.Kawahara, T.Okuda, Y.Orita, T.Matsumoto, K.Tomita: The effects of spinal cord distraction on
spinal cord function and blood flow in the dog, AO Spine Global Spine Congress 2013, (Hong Kong, '13.04).

0430I002(C.Fisher), P.P.Varga, S.Boriani, L.Rhines, N.Kawahara, D.Fourney, J.Reynolds, M.Fehlings, R.Schouten,
Z.Gokaslan: Spinal instability neoplastic score: an analysis of reliability and validity in radiologists an AOSpine
Knowledge Forum Tumor project, AO Spine Global Spine Congress 2013, (Hong Kong, '13.04).

－ 70 －

0430I003

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, E.Takahashi, T.Matsumoto: Arthroscopic treatment for
femoroacetabular impingement after healed femoral neck fractures, 12th Congress of AFJO (Assoiciation FranceJapon d'Orthopedie), (Kyoto, '13.05)，12th Congress of AFJO Program and Abstracts, 75, 2013.

0430I004

E.Takahashi, A.Kaneuji, R.Tsuda, T.Matsumoto: Relationship between bone cement thickness and cement creep abiomechanical study using collarless polished tapered stem, 12th Congress of AFJO (Assoiciation France-Japon
d'Orthopedie), (Kyoto, '13.05)，12th Congress of AFJO Program and Abstracts, 74, 2013.

0430I005(K.So), A.Kaneuji, Y.Kuroda, T.Matsumoto, S.Matsuda, H.Akiyama: Good clinical and radiographic outcomes of acementless total hip prosthesis with alkaline and heat treatments, 12th Congress of AFJO (Assoiciation FranceJapon d'Orthopedie), (Kyoto, '13.05)，12th Congress of AFJO Program and Abstracts, 69, 2013.

0430I006

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Arthrosopic treatment for cam type impingements after
healed femoral neck fractures, Annual Scientific Meeting ISHA2013 (International Society for Hip Arthroscopy),(Munich, '13.10).

0430I007

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Does rotational acetabular osteotomy affect subsequent
total hip arthroplasty?, 2013 Annual Congress ISTA (International Society for Technology in Arthroplasty), (Palm
Beach, '13.10).

－ 71 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Associate Professor

TAKADA Hisashi

cerebrovascular disease，endovascular therapy

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

SASAGAWA Yasuo

brain tumor

Assistant Professor

SIRAGA Syunsuke

cerebrovascular disease

Assistant Professor

YAMAMOTO Jiro

general neurosurgery

Assistant Professor

TSUKADA Tsuyoshi

general neurosurgery，neuroembryology

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly－ 72 －

1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001

Y.Sasagawa, O.Tachibana, M.Doai, T.Akai, H.Tonami, H.Iizuka: Internal carotid arterial shift after transsphenoidal
surgery in pituitary adenomas with cavernous sinus invasion., Pituitary., 16:465-70, 2013.

0440B002

T.Iida, H.Iizuka: Spinal chronic subdural hematoma associated with intracranial chronic subdural hematoma, The
Journal of the Japan Medical Society of Spinal Cord Lesion, 26:152-153, 2013 (in Japanese) .

0440B003

A.Sakai, H.Toga, O.Tachibana, T.Miwa: Assessment of treatment effect for acromegaly with sleep disorderedbreathing., Journal of Otolaryngology of Japan, 116:612-618, 2013 (in Japanese) .

Case Reports
0440D001

Y.Sasagawa, O.Tachibana, H.Iizuka: Undifferentiated sarcoma of the cavernous sinus after gamma knife
radiosurgery for pituitary adenoma., J. Clin. Neurosci., 20:1152-1154, 2013.

0440D002

Y.Sasagawa, O.Tachibana, T.Iida, H.Iizuka: Oncocytic meningioma presenting with intratumoral hemorrhage., J.
Clin. Neurosci., 20:1622-1624, 2013.

Presentations at Conference
International Conference (Presentations)
0440I001

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting distraction osteogenesis for
craniosynostosis, The 41th annual meeting of the international society for pediatric neurosurgery, (Mainz,
Germany, '13.09).

0440I002

Y.Sasagawa, O.Tachibana, M.Doai, T.Akai, H.Tonami, H.Iizuka: Internal carotid arterial shift after transsphenoidal
surgery in pituitary adenomas with cavernous sinus invasion, 37th European Society of Neuroradiology Annual
Meeting, (Frankfurt, Germany, '13.09).

0440I003

T.Tsukada, E.Simamura, H.Shimada, T.Akai, H.Iizuka, T.Hatta: Maternal immune activation impairs the maternalfetal leukemia inhibitory factor signal relay and reduces neural stem/progenitor cell proliferation, Neuroscience
2013, (San Diego, California, '13.11).

－ 73 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

NISHIO Akiko

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

TAGUCHI Hisao

Plastic and Reconstructive Surgery

Assistant Professor

DOI Yujin

Plastic and Reconstructive Surgery

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Assistant Professor

KAMIMURA Yuri

Plastic and Reconstructive Surgery

Assistant Professor

YAGISHITA Mikio

Plastic and Reconstructive Surgery

Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.
－ 74 －

Publications
Originals
0450B001

Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, K.Shimada, Y.Yamamoto, S.Kawakami: Nipple- or skin-sparing
mastectomy and immediate breast reconstraction by the "moving window" operation, Breast Cancer., 20:54-61,
2013.

0450B002

R.Kominami, H.Shinohara, S.Yasutaka, M.Kishibe: The human hippocampus observed by scanning electron
microscopy (SEM): The dentate gyrus is made of an array of the neuronal lamellae., Okajimas Folia Anat. Jpn.,
89:157-164, 2013.

0450B003

Y.Himi: Aquaporin 1 is involved in the adhesion and migration of mesenchymal tissue stem cells/cartilage
progenitor cells inthe human ear perichondrium., J. Kanazawa. Med. Univ., 38:9-19, 2013 (in Japanese) .

0450B004

M.Yagishita: Involvement of mesenchymal tissue stem cells and aquaporin 1 in rabbit auricular cartilage
regeneration from perichondrium., J. Kanazawa. Med. Univ., 38:43-52, 2013 (in Japanese) .

0450B005

M.Yamashita, K.Shimada: Calvarial bone grafts;indications and possible complications., The Japanese journal ofplastic & reconstructive surgery., 56:967-974, 2013 (in Japanese) .

Reviews
0450C002

K.Shimada: Negative pressure wound therapy for a traumatic skib defect in the extremity., The Japanese journal ofplastic & reconstructive surgery., 56:1161-1171, 2013 (in Japanese) .

Case Reports
0450D001

A.Nishio, K.Shimada, M.Yamashita, C.Yoshida, S.Kawakami, S.Nakada, H.Minato: True prehallux-like deformity of
the left foot;a case report., The Japanese journal of plastic & reconstructive surgery., 56:541-545, 2013 (inJapanese) .

0450D002

M.Yamashita, K.Shimada: Nasal deformity and nasal obstruction after rhinoplasty., The Japanese journal of plastic& reconstructive surgery., 56:661-665, 2013 (in Japanese) .

0450D003(Y.Haseda), T.Miyanaga, T.Minamisawa, A.Sakagami, A.Nishio: Two cases of streptococcal toxic shock syndrome
due to group a streptococcal infection among family members., J.Jpn.P.R.S., 33:433-441, 2013 (in Japanese) .

0450D004(T.Minamisawa), Y.Haseda, A.Nishio: Treatment for metacarpophalangeal joint of the thumb locked in flexed
position., J.Jpn.P.R.S., 33:722-776, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0450I001

K.Shimada: Treatment of sever hand injuries at our department, The 22th China-Japan Joint Meeting on Plastic
Surgery, (China, '13.08).

0450I002

M.Kishibe: Aggressive remodelling with pedicled skin flaps of the volar surface for the release of contractures ofthe fingers, The 22th China-Japan Joint Meeting on Plastic Surgery, (China, '13.08).

0450I003

A.Nishio: A clinical study of linear orbital floor fractures, The 22th China-Japan Joint Meeting on Plastic Surgery,(China, '13.08).

0450I004

T.Miyanaga: Perifascial Areolar Tissue Graft For Skin Ulcer Exposed Tendon or Bone, The 22th China-Japan Joint
Meeting on Plastic Surgery, (China, '13.08).

－ 75 －

0450I005

M.Yonezawa, A.Nishio, H.Daizo, K.Shimada, S.Kawakami: Surgical treatment of lymphedema, The 22th ChinaJapan Joint Meeting on Plastic Surgery, (China, '13.08).

0450I006

Y.Ikawa, M.Yagishita, Y.Himi, N.Koizumi, S.Kawakami, M.Shimasaki, Y.Ueda: Proliferation and induced
differentiation of auricular perichondrium cell., The 22th China-Japan Joint Meeting on Plastic Surgery, (China,'13.08).

0450I007

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting distraction osteogenesis for
craniosynostosis, The 41th annual meeting of the international society for pediatric neurosurgery, (Mainz,
Germany, '13.09).

－ 76 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Senior Assistant Professor

YASUI Yoshitomo

Pediatric surgery

Assistant Professor

OSHIKIRI Takahiro

Pediatric surgery

Assistant Professor

TAKAHASHI
Sadayoshi

Pediatric surgery

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Research Doctor

SHIRONOMAE
TsubasaFaculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

Y.Yasui, M.Kohno: The diagnosis and treatment of ovarian torsion in childhood and adolescence., J Abdom Emerg
Med, 33:941-945, 2013 (in Japanese) .

0460B002

T.Kuwahara, M.Kohno, S.Takahashi, Y.Yasui, T.Oshikiri, M.Ito, Y.Saikawa: Determination a relevant period of thepreventive gonadal resection in Y-chromosome-related disorders of sex development(DSD)., Journal of theJapanese Society of Pediatric Surgery., 49:969-974, 2013 (in Japanese) .

Case Reports
0460D001

Y.Yasui, M.Kohno, T.Shironomae, T.Kuwahara, S.Takahashi, T.Oshikiri, H.Tsuji: Laryngotracheal separation for a
type 4 laryngotracheoesophageal cleft with multiple signiflcant malformations., J. Pediatr. Surg., 1:277-280, 2013.

0460D002

Y.Yasui, M.Kohno, T.Shironomae, T.Kuwahara, S.Takahashi, T.Oshikiri: Retroperitoneoscopic resection of acongenital adrenal teratoma in an infant., J. Pediatr. Surg., 1:391-394, 2013.

－ 77 －

0460D003

Y.Yasui, M.Kohno, T.Kuwahara, S.Takahashi, T.Oshikiri: Pseudohypoaldsteronism type1 following surgicalcorrection of vesicoureteral reflux:a case report., Japanese Journal of Pediatric Urology, 22:127-130, 2013 (inJapanese) .

0460D004

Y.Yasui, M.Kohno, T.Kuwahara, S.Takahashi, T.Oshikiri: Three male cases of anorectal malformation that weretreated with anterior perineal anoplasty., Journal of the Japanese Society of Pediatric Surgery., 49:1012-1017,
2013 (in Japanese) .

－ 78 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication

Professor

KITAGAWA Kazuko

Professor(Additional Post)

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

lacrimal fluid

Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

OSADA Hiromi

cataract, ophthalmology

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Assistant Professor

TAKAHASHI Yorikocataract

ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 79 －

Publications
Originals
0470B001

E.Kubo, N.Hasanova, N.Fatma, H.Sasaki, DP.Singh: Elevated tropomyosin expression is associated with epithelialmesenchymal transition of lens epithelial cells., J. Cell. Mol. Med., 17:212-221, 2013.

0470B002(GM.Zoega), A.Arnarsson, H.Sasaki, PG.Soderberg, F.Jonasson: The 7-year cumulative incidence of cornea
guttata and morphological changes in the corneal endotheliu in the Reykjavik Eye Study., Acta Ophthalmol.
Scand., 91:212-218, 2013.

0470B003(B.Bhanrgavan), B.Chhunchha, N.Fata, E.Kubo, DP.Shigh: Epigenetic repression of LEDGF during UVB exposure
by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island.,
Epigenetics, 8:268-280, 2013.

0470B004(K.Araki-Sasaki), K.Hirano, Y.Osakabe, M.Kuroda, K.Kitagawa, H.Mishima, H.Obata, M.Yamada, N.Maeda,
K.Nishida, S.Kinoshita: Classification of secondary corneal amyloidosis and involvement of lactoferrin.,
Ophthalmology, 120:1166-1172, 2013.

0470B005(B.Chhunchha), N.Fatma, E.Kubo, P.Rai, SP.Singh, DP.Singh: Curcumin abates hypoxia-induced oxidative stressbased-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-kB
regulation., Am. J. Physiol., Cell Physiol., 304:C636-C655, 2013.

0470B006(T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki: FDTD analysis oftemperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45
GHz., Radiat Prot Dosimetry, 155:284-291, 2013.

0470B007

E.Kubo, N.Hasanova, H.Sasaki, DP.Singh: Dynamic and differential regulation in the microRNA expression in thedeveloping and mature cataractous rat lens., J. Cell. Mol. Med., 17:1146-1159, 2013.

0470B008(Y.Inoue), Y.Shimomura, M.Fukuda, D.Miyazaki, Y.Ohashi, H.Sasaki, Y.Tagawa, H.Shiota, N.Inada, S.Okamoto,K.Araki-Sasaki, T.Kimura, H.Hatano, H.Nakagawa, S.Nakamura, A.Hirahara, K.Tanaka, H.Sakuma: Multicentre
clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial
keratitis., Br. J. Ophthalmol., 97:1108-1112, 2013.

0470B009(A.Arnarsson), H.Sasaki, F.Jonasson: Twelve-year incidence of exfoliation syndrome in the Reykjavik eye study.,
Acta Ophthalmol., 91:157-162, 2013.

0470B010

M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki: Safety comparison of
additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., Clin. Ophthalmol., 7:515-520, 2013.

0470B011

M.Sasaki, M.Takahashi, E.Shibuya, A.Okamoto, N.Mita, Y.Takahashi, E.Kubo, H.Sasaki: Corrected near andintermediate vfisual acuity in eyes with aspheric mono focal intraocular lens., The Journal of the Japanese Society
for Cataract Research, 25:61-64, 2013 (in Japanese) .

0470B012

M.Fukuda, H.Nakashima, J.Haruta, S.Shibata, N.Shibata, H.Osada, Y.Seki, N.Mita, H.Sasaki: Safety of rebamipide
ophthalmic suspension for corneal epithelial cells: In vitro and In vivo study., Journal of the eye., 30:1467-1471,
2013 (in Japanese) .

0470B013(N.Ibaraki), E.Kubo, H.Sasaki: Cases in which prescribed glaucoma medications were unnecessary., Journal of theeye., 30:1472-1474, 2013 (in Japanese) .

Reviews
0470C002

H.Sasaki: Prevalence of cataract, Ophthalmology, 55:227-233, 2013 (in Japanese) .

0470C003

E.Kubo: Pharmacological prevention of cataract, Ophthalmology, 55:261-265, 2013 (in Japanese) .

0470C005

H.Sasaki: Risk Factors of Age-related cataract, The Journal of the Japanese Society for Cataract Research, 25:917, 2013 (in Japanese) .

－ 80 －

Presentations at Conference
International Conference (Presentations)
0470I001

E.Kubo, N.Hasanova, H.Osada, E.Kiyokawa, H.Sasaki, F.Nigar, S.Dhirendra: FGF2 Antagonizes the TGFβ2induced aberrant expression of tropomuosin and α-smooth muscle actin in mouse and human lens epithelial cells
and has a role in posterior capsule opacity, The Association for Research in Vision and Ophthalmology, (Seattle,'13.05).

0470I002

M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki: Difference in ocular damage by 40 and 95 GHz exposure to rabbit eye,
The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

0470I003

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, M.Takahashi, Y.Takahashi, H.Osada, K.Sasaki, E.Kubo:
Correlating visual function and size of area opacifid by retrodots based on retroillumination photography, The
Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

0470I004(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, K.Sasaki, H.Sasaki: Factors influencing visual function in eyes withretrodots by difference in size, The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

0470I005(T.Kawamorita), H.Uozato, H.Sasaki, Y.Shibata, M.Kanazawa, M.Hirota, Y.Jang, S.Arai, K.Shimizu: Schematic eyemodel based on the regression of age-dependent changes of the erystalline lens, The Association for Research in
Vision and Ophthalmology, (Seattle, '13.05).

0470I006

N.Hatsusaka, K.Sasaki, H.Sasaki: A comparison between casey eye institute (CEI) camera system and the EAS1000 camera in recording retro-dot opacities, The Association for Research in Vision and Ophthalmology, (Seattle,'13.05).

0470I007

M.Takahashi, H.Osada, N.Mita, E.Shibuya, N.Hatsusaka, Y.Takahashi, Y.Sakamoto, K.Sasaki, E.Kubo, H.Sasaki:
Contrast acuity in eyes with different types of lens opacity, The Association for Research in Vision andOphthalmology, (Seattle, '13.05).

0470I008

Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, E.Shibuya, E.Kubo, H.Sasaki: Optical simulation for subsurface nano glistening, The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

0470I009

A.Arimoto, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki, K.Kitagawa: Evaluation of the effect of rebamipide
ophthalmic suspension on the signs and symptoms of keratoconjunctivitis sicca in Sjogren's syndrome patients withor without punctal occlusions, 12th International Symposium on Sjogren's Syndrome, (Kyoto, '13.10).

0470I010(J.Chakarothai), Y.Suzuki, M.Taki, K.Wake, Kensuke Sasaki, S.Watanabe, M.Kojima: Analysis of millimeter-wave
exposure on rabbit eye using a hybrid PMCHWT-MoM-FDTD method, 2013 International Symposium on Antennas
and Propagation, (China, '13.10).

0470I011

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, K.Sasaki, E.Kubo: Retrodot-opaque-area and visualfunction, American Academy of Ophthalmology, (shiatosru, '13.11).

0470I012

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy of Electromagnetic Fields,(Washington, '13.11).

0470I013

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy on RF Electromagnetic
Fields, (Washingto, '13.11).

0470I014

M.Kojima, T.Okuno, D.Sliney: Animal studies of infrared cataract review of anial studies and discussions wolbarsht
and pitts studies (photochemical?) review of gldman and vogt experiments, The 2013 Baltimore optical Radiation
Workshop, (Baltimore, '13.12).

0470I015

H.Sasaki, M.Kojima, K.Sasaki: Epidemiological studies of caract with latitude -evdence for a thermal factor-, The
2013 Baltimore optical Radiation Workshop, (Baltimore, '13.12).

－ 81 －

0475

Department of Otorhinolaryngology

Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Senior Assistant Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Assistant Professor

YAMADA Kanako

Rhinology, generel otology

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant
Professor(Additional Post)

MIYAZAWA Toru

Otorhinolaryngology

Faculty

Keywords of Researcholfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep
apnea & snoar surgery

Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Yamada K, Yamamoto, Yamada K, Noda, Harita)
New educational system for endoscopic sinus surgery(Miwa , Shiga, Yamada K)
Auditory central functional imaging with MEG(Suzuka, Yamada K)
Clinical research for snoar and sleep apnea(Miwa, Sakai)

Publications
Originals
0475B001

H.Shiga, J.Taki, K.Washiyama, J.Yamamoto, S.Kinase, K.Okuda, S.Kinuya, N.Watanabe, H.Tonami, K.Koshida,
R.Amano, M.Furukawa, T.Miwa: Assessment of olfactory nerve by SPECT-MRI image with nasal thallium-201
administration in patients with olfactory impairments in comparison to healthy volunteers., PLoS ONE,
8:e57671;1-8, 2013.

0475B002(M.Higuchi), Y.Suzuka: An analytical method of auditory evoked responses for a long series of sounds using a
coherence function between brain signal and sound envelope., Audiol. Jpn., 56:276-282, 2013 (in Japanese) .

0475B004

A.Sakai, H.Toga, O.Tachibana, T.Miwa: Assessment of treatment effect for acromegaly with sleep disorderedbreathing., Journal of Otolaryngology of Japan, 116:612-618, 2013 (in Japanese) .

－ 82 －

Presentations at Conference
International Conference (Synposium)
0475H001

T.Miwa: Olfactory Nerve Transportation as Clinical Application for Olfactory Disorders, 20th World Congress of
the International Federation of Oto-Rhino-Laryngological Societies, (Seoul, Korea, '13.06).

0475H002

H.Shiga, T.Miwa: Nasal administered peptide and olfactory nerve transport to brain in vivo., The 16th Asian
Research Symposium in Rhinology, (Tokyo, '13.08).

0475H003

T.Miwa, H.Shiga, J.Yamamoto: Olfactory nerve transportation as clinical application for olfactory disorder, 7thInternational symposium on recent advances in rhinosinusitis and nasal polyposis, (Matsue, '13.10).

International Conference (Presentations)
0475I001

Y.Suzuka: Long Term Results of Autologous Fat Injection for Glottic Insufficiency, The 29th Congress of the Pan
Pacific Surgical Association, (Honolulu, '13.02).

0475I002

H.Shiga, M.Nagaoka, K.Washiyama, J.Yamamoto, R.Amano, T.Miwa: Assessment of nasally administered insulinlike growth factor-I accumulation in the cerebrum of mice with resected olfactory bulb., The 35th annual meetingof the Association for Chemoreception Sciences, (Hungtington Beach, USA, '13.04).

0475I003

J.Yamamoto, H.Shiga, K.Washiyama, R.Amano, T.Miwa: Effect of kamikihito (TJ-137) on nerve growth factor andolfactory nerve in vivo., The 35th annual meeting of the Association for Chemoreception Sciences, (Hungtington
Beach, USA, '13.04).

0475I004

Y.Suzuka: Measurements and an Analysis of Cocktail-Party Effect with Magnetoencephalography, International
Otopathology Society Meeting, (New York, '13.06).

0475I005

H.Shiga, J.Taki, K.Washiyama, J.Yamamoto, S.Kinuya, R.Amano, M.Furukawa, T.Miwa: Prognostic value of nasal
thallium-201 transport to olfactory bulb in patients with olfactory disorders., European Chemoreception Research
Organization 2013, (Leuven, Belgium, '13.08).

0475I006

Y.Suzuka: The present status and support system for women doctors in Japan, The 30th Congress of the PanPacific Surgical Association Japan Chapter, (Honolulu, '13.10).

0475I007

K.Yamada, J.Yamamoto, K.Yamada, H.Shiga, T.Miwa: Outcomes of olfactory function by endoscopic sinus surgery
in the patients with eosinophillic chronic sinusitis, 7th International symposium on recent advances in rhinosinusitis
and nasal polyposis, (Matsue, '13.10).

－ 83 －

0485

Department of Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

TSUTSUMIUCHI
Toshiki

General otorhinolaryngology

Keywords of Researchhead and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle
aspiration cytology, chemoradiotherapy

Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode)
New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government
cooperation (Tsuji, Shimode)
Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji,
Shimode)Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)

Publications
Originals
0485B001

A.Sakai, H.Toga, O.Tachibana, T.Miwa: Assessment of treatment effect for acromegaly with sleep disorderedbreathing., Journal of Otolaryngology of Japan, 116:612-618, 2013 (in Japanese) .

Case Reports
0485D001

Y.Yasui, M.Kohno, T.Shironomae, T.Kuwahara, S.Takahashi, T.Oshikiri, H.Tsuji: Laryngotracheal separation for a
type 4 laryngotracheoesophageal cleft with multiple signiflcant malformations., J. Pediatr. Surg., 1:277-280, 2013.

－ 84 －

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Senior Assistant Professor

WATANABE Seiji

Medical mycology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

TAKEDA Kiminobu

Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Research Doctor

HATTA Jyunko

Image analysis

Research Doctor

NANBU Masayuki

Dermatopathology

Research Doctor

KOJIMA Kiyoto

genetic diagnosis

Research Doctor

KITAYAMA Asuka

cutaneous malignant tumor

Research Doctor

MURAMOTO Mutsuko Immunology

Research Doctor

WAKASA Asako

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, langerhans cell

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

－ 85 －

Publications
Originals
0490B001
0490B002(R.Kano), M. Isizuka, M.Hiruma, T.Mochizuki, H.Kamata, A.Hasegawa: Mating type gene(MAT1-1)in Japaneseisolates of Trichophyton rubrum, Mycopathologia, 175:171-173, 2013.
(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Hiruma: Urease gene of Trichophyton rubrum var.

raubitschekii, J. Dermatol., 40:111-113, 2013.
0490B003(R.Kano), K.Anzawa, T.Mochizuki, K.Nishimoto, M.Hiruma, H.Kamata, A.Hasegawa: Sporothrix schenckii(sensu
strict S.globosa) mating type 1-2(MAT1-2) gene., J. Dermatol., 40:726-730, 2013

0490B004

T.Mochizuki, K.Anzawa, Y.Sakata, M.Fujihiro: Simple identification of Trichophyton tonsurans by chlamydosporelike structures produced in culture media., J. Dermatol., 40:1027-1032, 2013.

0490B005(H.Kobayashi), M.Yoshioka, K.Anzawa, T.Mochizuki: Cases of Microsporum canis infection between 2005 and2011 in a dermatology clinic in the southern part of Kanazawa city., Skin research, 12:219-223, 2013 (inJapanese) .

0490B006

Y.Sakata, T.Sakamoto, A.Kitayama, T.Ushigami, K.Anzawa, T.Fujii, S.Abe, A.Nishibu, T.Mochizuki: Mass
screenings for Trichophyton tonsurans infection in junior high school judo teams in Ishikawa prefecture, Japan.,
Journal of Pediatric Dermatology., 32:121-126, 2013 (in Japanese) .

0490B007

T.Mochizuki, S.Abe, H.Tanabe, T.Ushigami, K.Kojima, M.Nanbu, T.Sakamoto, J.Kawanishi, J.Hatta, K.Anzawa,
T.Nakamura, N.Yoshida, K.Ogawa: Efficacy of IKD-382 cream for tinea pedis with hyperkeratotic lesions.,
Nishinihon j. dermatol., 75:454-459, 2013 (in Japanese) .

Case Reports
0490D001

M.Hasei, K.Takeda, K.Anzawa, A.Nishibu, H.Tanabe, T.Mochizuki: Case of phaeohyphomycosis producing
sporotrichoid lesions., J. Dermatol., 40:638-640, 2013.

0490D002(H.Amano), C.Kishi, Y.Yokoyama, A.Shimizu, K.Anzawa, T.Mochizuki, O.Ishikawa: Microsporum canis infection
mimics pemphigus erythematosus., Indian J Dermatol., 2013;58:243, 2013.

0490D008

K.Kojima, T.Fujii, A.Nishibu, T.Mochizuki, Y.Niida: A Case of hereditary angioederma with blisters., Skin
research, 12:190‐194, 2013 (in Japanese) .

0490D012(A.Kawakita), A.Tanizawa, K.Suzuki, I.Hata, H.Takahashi, M.Kumakiri, K.Anzawa, T.Mochizuki, Y.Ohshima:
Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia., Japanese Journal of PediatricHematology/Oncology, 50:624-628, 2013 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0490H001

T.Mochizuki: Molecular diagnosis in mycosis -important for daily practice in dermatology clinics, The Scientific
Meeting and National Congress of“Crossing Boundaries: Mycology in the Study of Tropical Diseases in Indonesia,(Bandung, Indonesia, '13.06).

0490H002

T.Mochizuki: Prospect in the management of dermatomycoses in Japan, The Scientific Meeting and National
Congress of“Crossing BoundariesMycology in the Study of Tropical Diseases in Indonesia, (Bandung, Indonesia,'13.06).

International Conference (Presentations)
0490I001

T.Mochizuki, K.Anzawa, M.Fujihiro: Morphogenesis and species specificity of chlamydospore-like structures ofTrichophyton tonsurans , 2013 Congress of Asia Pacific Society for Medical Mycology, (Chengdu,China, '13.06).
0490I002(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Hiruma, S.Ikeda: Urease gene of Trichophyton
rubrum var. raubitschekii, 2013 Congress of Asia Pacific Society for Medical Mycology, (Chengdu,China, '13.06).
－ 86 －

0500

Department of Urology

Faculty
Title

Name

Field of Specialization

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

ISHII Takeo

general urology

Assistant Professor

NAKAI Dan

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001(K.Fujimoto), Y.Hirao, Y.Ohashi, Y.Shibata, K.Fuji, H.Tsuji, K.Miyazawa, M.Ohtani, R.Furuya, E.Boku: The
effects of chlormadinone acetate on lower urinary tract symptoms and erectile functions of patients with benign
prostatic hyperplasia: a prospective multicenter clinical study., Adv Urol., 2013:584678;1-8, 2013.

Case Reports
0500D001

I.Chikazawa, D.Nakai, K.Miyazawa, T.Tanaka, K.Suzuki, K.Sato, Y.Motoo: Neuroendcrine carcinoma of theprostate treated combined modality therapy., Jpn. J. Cancer Clin., 59：99-104, 2013 (in Japanese) .

0500D002

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, E.Kinoshita, T.Nojima: A case of renal pelvic urothelial carcinoma
with sarcomatous change., Japanese Journal of Clinical Urology, 67:269-272, 2013 (in Japanese) .

0500D003

I.Chikazawa, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, T.Uchibayashi: Two cases of ureterocele withureteral stone., Japanese Journal of Urological Surgery, 26:1015-1019, 2013 (in Japanese) .

－ 87 －

0500D004

I.Chikazawa, S.Miura, S.Nishida, K.Miyazawa, T.Tanaka, K.Suzuki, S.Nakata, T.Nojima: Spontaneous rupture of
renal cell carcinoma arising in the native kidney following living renal transplantation : A case report, Japanese
Journal of Urological Surgery, 26:1741-1744, 2013 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0500H001

K.Miyazawa, Y.Kohjimoto, S.Y.Nakada, M.Dunn: Treatment of acute obstructive pyelonephritis due to stone.,
Advancements in Urology 2013, (Las Vegas, '13.02).

0500H002

K.Miyazawa, S.Y.Nakada: Comparison of guidlines for the management of urolithiasis between the USA and Japan,
Advancements in Urology 2013, (Las Vegas, '13.02).

－ 88 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Professor

MAKINODA Satoru

Associate Professor

Field of Specialization

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines
Gynecologic Pathology, Tumor Virology, Sexually Transmitted
SASAGAWA Toshiyuki
Infection Research, Immunology

Associate
Professor(Additional Post)

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine

Senior Assistant Professor

WASEDA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

YAMAGUCHI Naotaka perinatal medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 89 －

Publications
Originals
0510B001

Z.Shang, H.Minato, T.Sasagawa, S.Nakada, E.Kinoshita, N.Kurose, T.Nojima, S.Makinoda: Detection of high-risk
human papillomavirus subtypes in cervical glandular neoplasia by in situ hybridization., Int J Clin Exp Pathol,
6:2168-2177, 2013.

0510B002(A.Ishizaki), K.Matsushita, HTT.Hoang, DM.Agdamag, CH.Nguyen, VT.Tran, T.Sasagawa, K.Saikawa, R.Lihana,
HV.Pham, X.Bi, VT.Ta, TV.Pham, H.Ichimura: E6 and E7 variants of human papillomavirus-16 and -52 in Japan,
the philippines, and vietnam., J. Med. Virol., 85:1069-1079, 2013.

0510B004(R.Irie), K.Ideta, T.Maehama, M.Shindo, T.Azuma, Y.Yamaguchi, M.Nomura, T.Sasagawa: J-HERS QOL study for
genital warts patients., Japanese Journal of Sexually Transmitted Infections, 24:103-109, 2013 (in Japanese) .

Reviews
0510C001

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

0510C002

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

Presentations at Conference
International Conference (Presentations)
0510I001

R.Fujii, T.Shibata, S.Makinoda, T.Utsunomiya: The effectiveness of G-CSF in the treatment of LUF, The
International Ovarian Conference 2013, (Taipei, '13.03).

0510I002

T.Waseda, T.Shibata, N.Neyatani, R.Fujii, S.Makinoda: Myometrial blood flow analysis in pregnant women with
FGR, 23rd World Congress on Ultrasound in Obstetrics and Gynecology, (Sydney, '13.10).

0510I003

R.Fujii, T.Shibata, N.Neyatani, T.Waseda, S.Makinoda, T.Utsunomiya: Granulocyte colony-stimulating factor (GCSF) prevents luteinized unruptured follicle(LUF) caused by clomiphene treatment, 2013 Conjoint IFFS/ASRM
Annual Meeting, (Boston, '13.10).

0510I004

T.Sasagawa, J.Sakamoto, H.Takagi, S.Makinoda: A novel ablation therapy using a liquid phenol for cervicalintraepithelial neoplasia(CIN), 23rd Asian & Oceanic Congress, (Bangkok, '13.10).

0510I005

H.Takagi, N.Neyatani, R.Fujii, T.Sasagawa, S.Makinoda: Efficacy and safety of long-term dienogest therapy forendometriosis, 23rd Asian & Oceanic Congress, (Bangkok, '13.10).

0510I006

J.Sakamoto, T.Sasagawa, S.Kamiura, H.Takagi, S.Makinoda: Reconsideration for high-risk human papilloma
virus(HPV) types in Japan, 23rd Asian & Oceanic Congress, (Bangkok, '13.10).

0510I007

R.Fujii, T.Shibata, N.Neyatani, T.Waseda, S.Makinoda, T.Utsunomiya: Usefulness of granulocyte colonystimulating factor (G-CSF) for luteinized unruptured follicle (LUF), The 9th Conference of the Pacific Rim Society
for Fertility and Sterility, (Kobe, '13.11).

0510I008

Y.Oka, T.Waseda, N.Neyatani, H.Takagi, S.Makinoda: Prenatal evaluating method of fetal lung maturity using
lung-to-liver signal intensity ratio at magnetic resonance imaging(MRI), 23rd World Congress on Ultrasound in
Obstetrics and Gynecology, (Sydney, '13.10).

－ 90 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

SHIRAISHI Miharu

Clinical anesthesia, Pain medicine, Palliative medicine

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Senior Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, ShockAssistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

NISHIIKE Satoshi

Clinical anesthesia, Nerve block, Vascular reactivity

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity

Assistant Professor

BEN Asami

Clinical anesthesia

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

MURATA Yuriko

Clinical anesthesia

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

SAITO Takahiro

Clinical anesthesia

Assistant Professor

TAKANO Mami

Clinical anesthesia

Assistant Professor

MORIKAWA Takanori Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Originals
0520B001

S. Nishiike, T. Hiramatsu, M. Shiraishi, Y. Ueda, H. Tsuchida: Relationship between vascular reactivity andexpression of HMGB1 in a rat model of septic aorta., J. Anesth., 27:684-692, 2013.

0520B002(K. Ogawa), M. Ogawa, K. Nishijima, M. Tsuda, G. Nishimura: Efficacy of contact needle therapy forchemotherapy-induced peripheral neuropathy., Evid Based Complement Alternat Med, 2013:928129;1-5, 2013.

－ 91 －

0520B003

M.Shiraishi, S.Nishiike, M.Ogawa, H.Tsuchida: Effectiveness and side effects of pregabalin for neuropathic pain inpatients with and without a history of antiepileptic therapy., J.J.S.P.C, 20:83-86, 2013 (in Japanese) .

Reviews
0520C001

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

0520C002

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

Presentations at Conference
International Conference (Key Note Lecture)
0520G001

H. Tsuchida: Geriatric anesthesia, 21st Annual Meeting of Chinese Society of Anesthesiology, (Tianjin, '13.09).

International Conference (Presentations)
0520I001

T. Hiramatsu, Y. Tanaka, S. Nishiike, H. Tsuchida: Caveolin-1 was involved in the attenuation of alpha-adrenergic
vasoconstriction in a rat model of abdominal sepsis, Euroanaesthesia 2013 The European Anaesthesiology
Congress, (Barcelona, '13.06).

－ 92 －

0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Professor

KAGECHIKA Kenji

Senior AssistantProfessor(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Others
0540F001

A.Kobe, T.Muratani, M.Kawahara, C.Tsuji, S.Yokogawa, K.Ushiyama, H.Maeda, K.Kagechika, A.Kaneuji, Y.Ohno:
Changes of peak torque and time and knee angle to peak torque for knee extensor and flexor after total hip
arthroplasty, Proceeding of the 7th World Congress of the International Society of Physical and Rehabilitation
Medicine, 210-211, 2013.

0540F002

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Inspection osteoporosis using ultrasound by
visualization of internal microstructure of heel bone., Proceeding of the 7th World Congress of the International
Society of Physical and Rehabilitation Medicine, 239-243, 2013.

0540F003

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Arteriosclerotic and ruptured blood vessel appear
as a change in the dynamic property of vessel wall dynamic deformability and strength by carotid artery echo.,
Proceeding of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine, 244245, 2013.

0540F004

T.Terai, R.Hashimoto, Y.Nitta, T.Monkawa, Y.Kawasaki, K.Kagechika: Effect of "individual placement andsupport"with psychoeducational approach for schizophrenics., Proceeding of the 7th World Congress of theInternational Society of Physical and Rehabilitation Medicine, 212-214, 2013.

0540F005(Y.Takagi), A.Nakanami, K.Kagechika, XY.Shang: Intrathecal Baclofen(ITB)therapy to severe spasticity.,
Proceeding of the 7th World Congress of the International Society of Physical and Rehabilitation Medicine, 204205, 2013.

－ 93 －

Presentations at Conference
International Conference (Synposium)
0540H001

M.Nakata: The history of WRMSDs in Japan: how it emerged, spread, and how it is today, 8th International
Conference on Prevention of Work-Related Musculoskeletal Disorders, (Busan, '13.07)，8th International
Conference on Prevention of Work-Related Musculoskeletal Disorders ABSTRACTS, p51, 2013.

International Conference (Presentations)
0540I001

K.Kagechika, M.Nakata, M.Tsubokawa, I.Takeuchi, A.Nakanami, Y.Takagi: Effect of the machine training to thepatients with Parkinson's disease, 9th International Congress on Mental Disorders & Other Non-Motor Features in
Parkinson's Disease and Related Disorders, (Seoul, '13.04).

0540I002

K.Kagechika, M.Nakata, M.Tsubokawa, I.Takeuchi, A.Nakanami, Y.Takagi: Evaluation of arteriosclerotic andraptured blood vessel by carotid artery echo, 9th International Congress on Mental Disorders & Other Non-Motor
Features in Parkinson's Disease and Related Disorders, (Seoul, '13.04).

0540I003

K.Kagechika, M.Nakata, M.Tsubokawa, I.Takeuchi, A.Nakanami, Y.Takagi: Evaluation of osteoporosis using
ultrasound by visualization of internal microstructure of heel bone, 9th International Congress on Mental Disorders& Other Non-Motor Features in Parkinson's Disease and Related Disorders, (Seoul, '13.04).

0540I004

A.Kobe, T.Muratani, M.Kawahara, C.Tsuji, S.Yokogawa, K.Ushiyama, H.Maeda, K.Kagechika, A.Kaneuji, Y.Ohno:
Changes of peak torque and time and knee angle to peak torque for knee extensor and flexor after total hip
arthroplasty, 7th World Congress of the International Society of Physical and Rehabilitation Medicine, (Beijing,'13.06).

0540I005

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Inspection osteoporosis using ultrasound by
visualization of internal microstructure of heel bone, 7th World Congress of the International Society of Physicaland Rehabilitation Medicine, (Beijing, '13.06).

0540I006

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Takagi: Arteriosclerotic and ruptured blood vessel appear
as a change in the dynamic property of vessel wall dynamic deformability and strength by carotid artery echo, 7thWorld Congress of the International Society of Physical and Rehabilitation Medicine, (Beijing, '13.06).

0540I007

T.Terai, Y.Nitta, T.Monkawa, Y.Kawasaki, K.Kagechika: Effect of "individual placement and support"withpsychoeducational approach for schizophrenics, 7th World Congress of the International Society of Physical andRehabilitation Medicine, (Beijing, '13.06).

0540I008(Xiaoying.Shang), K.Kagechika, Stoubin Luo, Yasutaka Takag: CI therapy Clinical Application, 7th World Congressof the International Society of Physical and Rehabilitation Medicine, (Beijing, '13.06).

0540I009(Y.Takagi), A.Nakanami, K.Kagechika, Xiao Ying Shang: Intrathecal Baclofen(ITB)therapy to severe spasticity, 7thWorld Congress of the International Society of Physical and Rehabilitation Medicine, (Beijing, '13.06).

0540I010

M.Nakata, Y.Yamada, K.Kagechica, PO.Eriksson: Intervention on work-related musculoskeletal
disorders(WRMSDs) and depression among factory workers, a pilot study, 8th International Conference on
Prevention of Work-Related Musculoskeletal Disorders, (Busan, '13.07)，8th International Conference on
Prevention of Work-Related Musculoskeletal Disorders ABSTRACTS, p214, 2013.

0540I011

K.Kagechika, Y.Okawa, N.Ikeda, A.Kobe, Y.Ohno, A.Nakanami, Y.Takagi: Effect Verfication after 365-days
Rehabilitation System is Introduced in Japanese Convalescence Rehabilitation Ward, The 6th Korea-Japan Joint
Stroke Conference, (Osaka, '13.10).

－ 94 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Associate Professor

OGURA Kenichi

Emergency, Neurosurgery

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

GOTO Tetsuro

Emergency

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

IWAI Junichi

Emergency

Research Doctor

WATANABE Atsushi

Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 95 －

0570

Department of Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Senior AssistantProfessor(Additional Post)

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino: Cardiac
BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., The
Internet Journal of Cardiovascular Research., 8, 2013.

Case Reports
0570D001

T.Kanda, T.Mizuno, M.Ishigaki, K.Nakajima, T.Matsue, M.Fukushima, H.Minato, N.Nojima, S.Atsushi, K.Ishigami,
H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, A.Fukuda, Y.Izumi, N.Takekoshi:
Spontaneous remission of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly., Case Rep
Oncol., 6:269-274, 2013.

－ 96 －

0575

Department of Gastroenterological Endoscopy

Faculty
Title

Name

Professor

ITO Tohru

Associate Professor

Senior Assistant Professor

Assistant Professor

Field of Specialization

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAWAURA Ken
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Presentations at Conference
International Conference (Synposium)
0575H001

T.Ito: Hereditary neoplasms of upper and lower gastrointestinal tract., The 15th Japan-Russia Endoscopy
Symposium, (Russia : Moscow, '13.02).

－ 97 －

0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

Assistant Professor

TOMIYAMA Takashi

Oral infectious diseases

Assistant Professor

HASUMOTO Miho

Orthodontics

Assistant Professor

KATO Koichiro

Oral cancer

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Case Reports
0580D001

N.Demura, M.Hasumoto, N.Segami: Bilateral craniofacial microsomia: orthognathic treatment for an advanced
dentofacial deformity, Am J Orthod Dentofacial Orthop, 143:404-411, 2013.

－ 98 －

University Hospital

0635

Hepatology

Faculty
Title

Name

Field of Specialization

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Associate Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Assistant Professor

SAITO Takashi

Treament for metabolic syndrome

Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Hepatic support system for severe alcoholic hepatitis③Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver
３ Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0635B001

N.Toshikuni, A.Fukumura, N.Hayashi, T.Nomura, M.Tsuchishima, T.Arisawa, M.Tsutsumi: Comparison of therelationships of alcoholic and nonalcoholic fatty liver with hypertension,diabetes mellitus,and dyslipidemia., J. Clin.
Biochem. Nutr., 52:82-88, 2013.

0635B002

M.Kitadate, T.Shibamoto, M.Tsutsumi, H.Tonami: Portal venular constriction during anaphylactic shock inanesthetized rats., Biomed. Res., 34:61-68, 2013.

0635B003

N.Hayashi, J.George, H.Shiroeda, T.Saito, N.Toshikuni, M.Tsuchishima, T.Arisawa, M.Tsutsumi: Irsogladine
maleate for the treatment of recurrent aphthous stomatitis in hepatitis C virus patients on pegylated-interferon andribavirin: a pilot study., J. Gastroenterol. Hepatol., 28:1015-1018, 2013.
－ 99 －

0635B004

N.Hayashi, J.George, M.Takeuchi, A.Fukumura, N.Toshikuni, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived
advanced glycation end-products promote alcoholic liver disease., PLoS ONE, 8:e70034;1-14, 2013.

0635B005

M.Tsuchishima, J.George, H.Shiroeda, T.Arisawa, T.Takegami, M.Tsutsumi: Chronic ingestion of ethanol induces
hepatocellular carcinoma in mice without additional hepatic insult., Dig. Dis. Sci., 58:1923-1933, 2013.

0635B006

N.Toshikuni, H.Shiroeda, K.Ozaki, Y.Matsue, T.Minato, T.Nomura, N.Hayashi, T.Arisawa, M.Tsutsumi: Advanced
ultrasonography technologies to assess the effects of radiofrequency ablation on hepatocellular carcinoma., Radiol
Oncol., 47:224-229, 2013.

0635B007

T.Nomura, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, K.Matsunaga, T.Otsuka, M.Nakamura,
N.Toshikuni, T.Shibata, T.Arisawa: Influence of HRH2 promoter polymorphism on aberrant DNA methylation of
DAPK and CDH1 in the gastric epithelium., BMC Gastroenterol., 13:1471-1479, 2013.

0635B008

T.Arisawa, T.Tahara, H. Shiroeda, T.Minato, Y.Matsue, T.Saito, T.Fukuyama, T.Otsuka, A.Fukumura,
M.Nakamura, T.Shibata: Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese
subjects., J. Gastroenterol., 48:73-80, 2013.

0635B009

R.Hayashi, T.Tahara, H.Shiroeda, T.Saito, M.Nakamura, M.Tsutsumi, T.Shibata, T.Arisawa: Influence of IL17A
polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis, Clin. Exp. Med., 13:239-244,
2013.

Presentations at Conference
International Conference (Key Note Lecture)
0635G001

M.Tsutsumi: Binge Produces NASH from obesity induced simple steatosis, 14th CONGRESS OF ESBRA, (Warsaw,'13.09).

International Conference (Presentations)
0635I001

T.Arisawa, H.Yamada, T.Tahara, M.Nakamura, T.Nomura, R.Hayashi, K.Matsunaga, T.Otsuka, N.Toshikuni,
H.Shiroeda, M.Tsutsumi, T.Shibata: The genetic polymorphism of pre-,icroRNA938,targeting IL-17A 3'-UTR,isassociated with the rick for DAP-kinase hypermethylation in helicobacter pylori infected japanese subjects.,
Digestive Disease Week 2013, (Orando, '13.05).

0635I002

N.Toshikuni, N.Hayashi, A.Fukumura, Y.Matsue, T.Minato, T.Nomura, T.Saito, K.Ozaki, H.Shiroeda,
M.Tsuchishima, T.Arisawa, M.Tsutsumi: Differentiation of alcoholic liver disease from nonalcoholic fatty liverdisease using a logistic regression model based on clnical parameters., Digestive Disease Week 2013, (Orlando,'13.05).

0635I003

J.George, N.Hayashi, M.Takeuchi, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived advanced glycation endproducts promote alcholic liver disease., Digestive Disease Week 2013, (Orlando, '13.05).

0635I004

N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi, T.Arisawa: Serum endocan as a novel prognostic biomarker inhepatocellular carcinoma patients, 21th United European Gastroenterology Week Berlin,Germany, (Germany,'13.10).

0635I005

M.Tsutsumi, J.George, N.Hayashi, M.Tsuchishima: Carbohydrate-Deficient Transferrin as a useful biomarker fordifferentiating nonalcoholic steatohepatitis from alcoholic hepatitis., 8th International Symposium on Alcoholic
Liver and Pancreatic Diseases and Cirrhosis, (New Delhi, '13.11).

－ 100 －

0675

Health Evaluation Center

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Shinobu

Clinical cardiology

Professor

ASAJI Takayoshi

Heartfailure

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

YASUDA Yukio

evidence-based health care

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/ Disease and Medical expenditure

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

Assistant Professor

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Assistant
Professor(Additional Post)

HAYASAKI Hisae

lifestyle-related disease

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence
from practice at a worksite in Japan., PLoS ONE, 8:e55836;1-9, 2013.

0675B002(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women, Endocrinology, 170:131-139, 2013.

0675B003

Y.Morikawa, M.Sakurai, K.Nakamura, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Correlation
between shift-work-related sleep problems and heavy drinking in Japanese male factory workers., Alcohol Alcohol.,
48:202-206, 2013.

－ 101 －

0675B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Sasaki, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, H.Nakagawa: Family histry of diabetes, lifestyle factors, and the 7-year incident risk oftype 2 diabetes mellitus in middle-aged Japanese men and women., J Diabetes Investig, 4:261-268, 2013.

0675B005(Y.Murakami), T.Okamura, K.Nakamura, K.Miura, H.Ueshima: The clustering of cardiovascular disease risk factors
and their impacts on annual medical expenditure in Japan: community-based cost analysis using Gamma regression
models., BMJ Open, 3:e002234, 2013.

0675B006(R.Sato), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, Y.Suwazono: Twenty-two-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan., Open J
Nephrol., 3:205-210, 2013.

0675B007

K.Nakamura, K.Miura, H.Nakagawa, T.Okamura, N.Okuda, K.Nishimura, S.Yasumura, K.Sakata, H.Hidaka,
A.Okayama: Treated and untreated hypertension, hospitalization, and medical expenditure: an epidemiologicalstudy in 314 622 beneficiaries of the medical insurance system in Japan., J. Hypertens., 31:1032-1042, 2013.

0675B008(K.Miura), J.Stamler, I.J.Brown, H.Ueshima, H.Nakagawa, M.Sakurai, Q.Chan, L.J.Appel, A.Okayama, N.Okuda,
J.D.Curb, B.L.Rodriguez, C.Robertson, L.Zhao, P.Elliott, for the intermap reserch group: Relationship of dietarymonounsaturated fattty acids to blood pressure: the international study of macro/micronutrients and bloodpressure., J. Hypertens., 31:1144-1150, 2013.

0675B009

A.T.N.Nguyen, M.Nishijo, E.Hori, N.M.Nguyen, T.T.Pham, K.Fukunaga, H.Nakagawa, A.H.Tran, H.Nishijo:
Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspringrats., Environ Health., 7:1-14, 2013.

0675B010(MN.Nguyen), M.Nishijo, ATN.Nguyen, A.Bor, T.Nakamura, E.Hori, H.Nakagawa, T.Ono, H.Nishijo: Effects ofmaternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on parvalbumin-and calbindin-immunoreactive neurons
in the limbic system and superior colliculus in rat offspring., Toxicology, 314:125-134, 2013.

0675B011(T.Hisamatsu), T.Ohkubo, K.Miura, T.Yamamoto, A.Fujiyoshi, N.Miyagawa, A.Kadota, N.Takashima, S.Nagasawa,
Y.Kita, Y.Murakami, A.Okayama, M.Horie, T.Okamura, H.Ueshima, H.Nakagawa, for the NIPPON DATA90
research group: Association between J-point elevation and death from coronary artery disease, Circ. J., 77:12601266, 2013.

0675B012

M.Sakurai, S.Saitoh, K.Miura, H.Nakagawa, H.Ohnishi, H.Akasaka, A.Kadota, Y.Kita, T.Hayakawa, T.Ohkubo,
A.Okayama, T.Okamura, H.Ueshima, for the NIPPON DATA 90 Research Group: HbA1c and the risks for allcause and cardiovascular mortality in the general Japanese population: NIPPON DATA90., Diabetes Care.,
36:3759-3765, 2013.

0675B013

Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, Y.Yamada: Elevated serum gamma-glutamyltransferase (GGT)
activity and the development of chronic kidney disease (CKD) in cigarette smokers., Nephrourol Mon, 5:967-973,
2013.

0675B014(T.Inohara), S.Kohsaka, T.Okamura, M.Watanabe, Y.Nakamura, A.Higashiyama, A.Kadota, N.Okuda, T.Ohkubo,
K.Miura, A.Okayama, H.Ueshima, H.Nakagawa, for the NIPPON DATA 80/90 reserch group: Long-term outcomeof healthy participants with atrial premature complex: a 15-year follow-up of the NIPPON DATA 90 cohort., PLoS
ONE, 11:e80853;1-7, 2013.

0675B015(A.Kadota), K.Miura, T.Okamura, A.Fujiyoshi, T.Ohkubo, T.Kadowaki, N.Takashima, T.Hisamatsu, Y.Nakamura,
F.Kasagi, H.Maegawa, A.Kashiwagi, H.Ueshima, H.Nakagawa, for the SESSA research group and for the NIPPONDATA80/90 research group: Carotid intima-media thickness and plaque in apparently healthy Japanese individuals
with an estimated 10-year absolute risk of CAD death according to the Japan atherosclerosis society (JAS)guidelines 2012: The Shiga epidemiorlogical study of subclinical atherosclerosis(SESSA), J. Atheroscler. Thromb.,
20:755-766, 2013.

0675B016

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: The effects of continuing anddiscontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working
population in Japan., Environ. Health Prevent. Med., 18:24-32, 2013.

0675B017

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Distribution of and factors
contributing to chronic kidney disease in a middle-aged working population., Environ. Health Prevent. Med., 18：466-476, 2013.

－ 102 －

0675B018

M.Ishizaki, N.Kawakami, R.Honda, Y.Yamada, H.Nakagawa, Y.Morikawa, The Work Stress and Health Cohort
Study Group: A prospective study of psychosocial work characteristics and long sick leave of Japanese male
employees in multiple workplaces., Ind. Health, 51:398-405, 2013.

0675B019(H.D.Manh), T.Kido, R.Okamoto, S.X.Liang, N.H.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, D.V.Tung, D.D.Nhe, N.N.Hung, L.K.Son: The relationship between dioxins and salivary
steroid hormones in Vietnamese primiparae., Environ. Health Prevent. Med., 18:221-229, 2013.

0675B020(GM.Singh), G.Danaei, F.Farzadfar, GA.Stevens, M.Woodward, D.Wormser, S.Kaptoge, G.Whitlock, Q.Qiao,
S.Lewington, E.Di Angelantonio, S.Vander Hoorn, CM.Lawes, MK.Ali, D.Mozaffarian, M.Ezzati, M.Sakurai,
H.Nakagawa, K.Nakamura, Y.Morikawa, Global Burden of Metabolic Risk Factors of Chronic Diseases
Collaborating Group: Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE);
Emerging Risk Factor Collaboration (ERFC); Prospective Studies Collaboration (PSC). The age-specificquantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis., PLoS
ONE, 8:e65174;1-10, 2013.

0675B021(W.Ruangyuttikarn), A.Panyamoon, K.Nambunmee, R.Honda, W.Swaddiwudhipong, M.Nishijo: Use of the kidney
injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically
exposed to cadmium in the environment., Springerplus, 2:533;1-8, 2013.

0675B022

PT.Tai, M.Nishijo, N.Thi Nguyet Anh, S.Maruzeni, H.Nakagawa, H.Van Luong, T.Hai Anh, R.Honda, T.Kido,
H.Nishijo: Dioxin exposure in breast milk and infant neurodevelopment in Vietnam., Occup. Environ. Med.,
70:656-662, 2013.

0675B023(S.Satarug), W.Swaddiwudhipong, W.Ruangyuttikarn, M.Nishijo, P.Ruiz: Modeling cadmium exposures in low- andhigh-exposure areas in Thailand., Environ. Health Perspect., 121:531-536, 2013.

0675B024

M.Nishijo, TN.Nghi, HD.Manh, PT.Tai, NTN.Anh, PHA.Vu, NT.Nguyen, NX.Hung, HM.Hoan, HC.Hai, H.Nishijo,
T. Hai-Anh, HV.Luong, T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Dioxin concentration in breast milk ofprimipara mothers in Bien Hoa, a hot spot area in Vietnam －A preliminary study in 2012－., Organohalogen
Compounds., 75:1167-1170, 2013.

0675B025(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV.Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., Organohalogen Compounds., 75:1321-1324, 2013.

0675B026(HD.Manh), T.Kido, R.Okamoto, XL.Sun, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: Current elevated dioxin level in serum of Vietnamese old men: Past exposure or
current exposure., Organohalogen Compounds., 75:1316-1320, 2013.

0675B027(XL.Sun), T.Kido, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: The relationship between dioxin and steroid hormones in serum of Vietnamese men.,
Organohalogen Compounds., 75:314-317, 2013.

0675B028(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa, N.Nemoto, A.Yokoyama, H.Kimura: SEM-EDX Elemental
content maps of organisms in radioac-tive environmental pollution by FDNPP accident in 2011., Kahokugata Lake
Science, 16:7-24, 2013 (in Japanese) .

0675B029(T.Koyama), S.Yamamoto, K.Yoshida, Y.Arai, M.Sakurai, K.Nakamura, M.Nishijyo, Y.Nakanishi, S.Nagasawa,
Y.Morikawa, M.Tabata, H.Nakagawa: Calcium intake and associated other dietary factors in healthy enderly
people., Hokuriku Japanese Journal of Public Health., 40:6-13, 2013 (in Japanese) .

0675B030(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa: Distribution of Sr,Cs,Np,and Pu in radioactive polluted paddy
soils and organisms., Journal of Fossil Research, 46：35-57, 2013 (in Japanese) .

0675B031

M.Nakashima, Y.Morikawa, Y.Hamazaki, S.Sakurai, J.Kitagawa, M.Sakurai, H.Nakagawa: Total smoking ban on an
university campus and acquisition of smoking habits., Jpn J School Health, 55:396-401, 2013 (in Japanese) .

Reviews
0675C001

Y.Yamada, Y.Noborizaka, M.Ishizaki: Chronic kidney disease(CKD) as an emerging lifestyle disease., Hokuriku
Japanese Journal of Public Health., 39：21-27, 2013 (in Japanese) .
－ 103 －

0675C004

M.Sakurai: Usefulness of glycated hemoglobin (HbA1c) measurement in healthy adults., Hokuriku Japanese Journalof Public Health., 40:1-5, 2013 (in Japanese) .

Others
0675F001(H.Teranishi), M.Nishijo: Environmental Cadmium Conference 2013: Health risk of environmental cadmium
contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M, Ruangyuttikarn W eds) Lessons
from itai-itai disease and cadmium pollution in Japan, Chiang Mai University, 4-8, 2013.

0675F002

M.Nishijo, S.Maruzeni, K.Nakamura, H.Nakagawa: Environmental Cadmium Conference 2013: Health risk ofenvironmental cadmium contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M,
Ruangyuttikarn W eds) Mortality of itai-itai disease patients and residents in a Cd polluted Jinzu River basin,
Toyama, Japan, Chiang Mai University, 9-14, 2013.

Presentations at Conference
International Conference (Presentations)
0675I001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Rice consumption and incident risk for type 2 diabetes in Japanese men andwomen., 73rd Scientific Sessions, American Diabetes Association, (Chicago, IL, USA, '13).

－ 104 －

Medical Research Institute7100

Department of Life Science

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle, transformation

Professor(Additional Post)

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TASAKI Takafumi

Protein regulation by the post-translational modifications and its
underlying molecular mechanisms

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Senior Assistant Professor

MURAKAMI Manabu

Pathogenicity of flavivirus isolated from the field-collectedmosquitoes

Assistant Professor

TANIGUCHI Makoto

Molecular and Cellular Biology, Lipid Biochemistry

Researcher

NAKAMURA Yuka

Molecular and Cellular Biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, "transcriptome, proteome, apoptosis, ultra micro structure", "mouse germ cells, DNA repair, fibroblast
growth factor", tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy

Outline of Research
１．Study on viral replication and pathogenicity
２．Molecular mechanism of carcinogenesis and metastasis
３．Research on plolyploidization and polyploid cells
４．Analyses of transcription and mRNA decay
５．Protein regulation by the post-translational modifications and its underlying molecular mechanisms

Publications
Originals
7100B001

Y.-S. Jiang, M.Maeda, M.Okamoto, M.Fujii, R.Fukutomi, M.Hori, M.Tatsuka, T.Ota: Centrosomal localization of
RhoGDIβ and its relevance to mitotic processes in cancer cells., Int. J. Oncol., 42:460-468, 2013.

7100B002

N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna,
Y.Motoo: Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabinesensitivity., Mol Clin Oncol., 1:100-104, 2013.

7100B003(A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai,
K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto: Aberrant glycogen synthase kinase 3β is involved in pancreaticcancer cell invasion and resistance to therapy., PLoS ONE, 8:e55289;1-12, 2013.
－ 105 －

7100B004

K.Fujikawa, M.Miyagoshi, H.Yamagishi: Dodecaploid H1 embryonic stem cells abolished pluripotency in L15F10
medium both with and without leukemia inhibitory factor., Hum. Cell., 26:97-104, 2013.

7100B005(S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura: Inhibition of mTORC2 but not mTORC1
up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell
carcinoma., J. Urol., 189:1921-1929., 2013.

7100B006

M.Miyagoshi, K.Fujikawa-Yamamoto, H.Yamagishi: The establishment of tetraploid human embryonic cells using
demecolcine., Cytologia (Tokyo), 78:417-423, 2013.

7100B007(ST.Kim), T.Tasaki, A.Zakrzewska, YD.Yoo, KS.Sung, S-H.Kim, H.Cha-Molstad, J.Hwang, KA.Kim, BY.Kim,
YT.Kwon: The N-end rule proteolytic system in autophagy., Autophagy, 9:1100-1103, 2013.

7100B008(G.Boso), T.Tasaki, YT.Kwon, NV.Somia: The N-end rule and retroviral infection: no effect on integrase., Virol.
J., 10:233;1-14, 2013.

7100B009

M.Tsuchishima, J.George, H.Shiroeda, T.Arisawa, T.Takegami, M.Tsutsumi: Chronic ingestion of ethanol induces
hepatocellular carcinoma in mice without additional hepatic insult., Dig. Dis. Sci., 58:1923-1933, 2013.

7100B010

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

7100B011(S.Tetsuka), K.Tominaga, E.Ohta, K.Kuroiwa, E.Sakashita, K.Kasashima, T.Hamamoto, M.Namekawa, M.Morita,
S.Natsui, T.Morita, K.Tanaka, Y.Takiyama, I.Nakano, H.Endo: Paraneoplastic cerebellar degeneration associatedwith an onconeural antibody against creatine kinase,brain-type., J. Neurol. Sci., 335:48-57, 2013.

7100B012(M.Hori), T.Miki, M.Okamoto, F.Yazama, H.Konishi, H.Kaneko, F.Shimamoto, T.Ota, A.Temme, M.Tatsuka: The
detergent-soluble cytoplasmic pool of Survivin suppresses anoikis and its expression is associated with metastatic
disease of human colon cancer., PLoS ONE, 8:e55710;1-14, 2013.

7100B013(H.Sakamoto), M.Hirano, M.Samukawa, S.Ueno, S.Maekura, H.Fujimura, M.Kuwahara, Y.Hamada, C.Isono,
K..Tanaka, S.Kusunoki, Y.Nakamura: Details of trearment-related difficulties in men with Anti-N-Methyl-DAspartate receptor encephalitis., Eur. Neurol., 69:21-26, 2013.

7100B014

K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami: Chk1-mediated phosphorylation of receptor-associated latetransducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., Genes Cells, 18:369386, 2013.

7100B015(S.Nukuzuma), M.Kameoka, S.Sugiura, K.Nakamichi, C.Nukuzuma, T.Takegami: Suppressive effect of PARP-1
inhibitor on JC virus replication in vitro., J. Med. Virol., 85:132-137, 2013.

7100B016(C.Yoshikawa), F.Takano, Y.Ishigaki, M.Okada, S.Kyo, N,Suzuki, K.Sugiura, K.Koike: Effect of porcine placental
extract on collagen production in human skin fibroblasts In Vitro, Gynecol Obstet (Sunnyvale), 3:1000186;1-4,
2013.

7100B017(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa, N.Nemoto, A.Yokoyama, H.Kimura: SEM-EDX Elemental
content maps of organisms in radioac-tive environmental pollution by FDNPP accident in 2011., 河北潟総合研究,
16:7-24, 2013 (in Japanese) .

7100B018(K.Park), M.Tahara, K.Tanaka, M.Tanaka: Altitudinal hemianopsia in Japanese patients with NMO or NMO
spectrum disorder., Neurological Medicine, 78:118-121, 2013 (in Japanese) .

7100B019(K.Tazaki), T.Takehara, Y.Ishigaki, H.Nakagawa: Distribution of Sr,Cs,Np,and Pu in radioactive polluted paddy
soils and organisms., Journal of Fossil Research, 46：35-57, 2013 (in Japanese) .

Reviews
7100C001

R.Tomioka, K.Tanaka: Stiff-person syndrome and related autoantibodies., Brain and nerve., 65:395-400, 2013 (inJapanese) .

7100C006

K.Takana: Autoimmune encephalitis /Encephalopathy and apheresis., Japanese Journal of Apheresis, 32:191-197,
2013 (in Japanese) .
－ 106 －

Case Reports
7100D001(Y.Hachiya), R.MIyata, N.Tanuma, K.Hongoku, K.Tanaka, K.Shimoda, S.Kanda, A.Hoshino, Y.Hanafusa,
S.Kumada, E.Kurihara, M.Hayashi: Autoimmune neurological disorders associated with group-A beta-hemolytic
streptococcal infection., Brain Dev., 35:670-674, 2013.

7100D002

U.Kawai, M.Fujita, S.Nagayama, K.Tanaka, M.Matsui: Late-onset anti-SRP antibody-positive mypathy with rapidly
progressive dysphagia and respiratory failure., Neurological Medicine, 78:579-581, 2013 (in Japanese) .

7100D003(K.Kawanishi), M.Morita, K.Nakahara, S.Tetsuka, T.Kouki, K.Tominaga, H.Endo, T.Yashiro, K.Tanaka, I.Nakano:
Paraneoplastic cerebellar degeneration with bladder cancer confirmed the existence of an anti-neural antibody.,
Brain and nerve., 65:1401-1405, 2013 (in Japanese) .

7100D004(K.Park), M.Komori, K.Tanaka, M.Tanaka: MS-like lesions of brain MRI in NMO-related disorder., Neurological
Medicine, 78:477-479, 2013 (in Japanese) .

7100D005(K.Hara), M.Tateyama, N.Suzuki, K.Shibano, K.Tanaka, H.Ishiguro: Sporadic case of non-progressive neurogenic
muscular atrophy localized in both calf muscles., Clinical Neurology, 53:551-554, 2013 (in Japanese) .

Short Communications
7100E001(M.Tanaka), M.Oono, R.Motoyama, K.Tanaka: Longitudinally extensive spinal cord lesion after initiation,and
multiple extensive brain lesions after cessation of fingolimod treatment in a patient with recurrent myelitis andanti-aquaporin4 antibodies., Clin. Exp. Neuroimmunol., 4:239-240, 2013.

7100E002(H.Fujii), S.Kubo, T.Yunoki, K.Sato, K.Takamatsu, K.Tanaka, Y.Takahashi, M.Kuriyama: Glioblastoma withovarian teratoma having N-methy1-D-aspartate receptor(NMDAR)antibody in CSF., Clinical Neurology, 53:712715, 2013 (in Japanese) .

Others
7100F001(M.Tanaka), K.Park, K.Tanaka: Reduced fingolimod dosage treatment for patients with multiple sclerosis andlymphopenia or neutropenia., Mult. Scler., 19:1244-1245, 2013.

Presentations at Conference
International Conference (Synposium)
7100H001

T.Tasaki, ST. Kim, A. Zakrzewska, YT. Kwon: UBR4, and N-recognin of the N-end rule pathway, and its role inyolk sac vascular development and autophagy, THE 35th NAITO CONFERENCE on The Ubiquitin-Proteasome
System: From Basic Mechanisms to Phathophysiological Roles, (Sapporo, '13.07).

International Conference (Presentations)
7100I001

K.Iwai, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: Oppsite directional regulations of microRNA
expression in arterial smooth muscle cell by HMGA1 and CTCF on the scaffold/matrix-attachment regions, The
77th Annual Scientific Meeting of the Japanese Circulation Society, (Yokohama, '13.03)，Circulation Journal,
77(Suppl. I)：I-1648, 2013.

7100I002

K.Tanaka, M.Fujita, Y.Ishigaki, N.Kato, M.Matsui, M.Tanaka, T.Takegami: Effects of the CSF from anti-NMDA
receptor encephalitis patient on the cultured neurons, The American Academy of Neurology's 65th the ANN
Annual Meeting, (SanDiego, '13.03).

7100I003

T.Shimasaki, Y.Ishigaki, A.Kitano, T.Takata, T.Arisawa, N.Ueda, T.Kosaka, T.Takegami, Y.Motoo, N.Tomosugi,
T.Minamoto: Glycogen synthase kinase 38 inhibition sensitizes pancreatic cancer to gemcitabine., Digestive
Disease Week 2013, (Orlando, '13.05).

－ 107 －

7100I004

M. Taniguchi, K. Kitatani, Y. Taguchi, T. Takegami, H. Umehara, T. Okazaki: Sphingosine-1-phosphate lessens
ceramide-mediated cell death in IL-2 deprived natural killer cells, FASEB Science Research Conference, (Niseko,'13.08).

7100I005

K.Tanaka, M.Fujita, M.Matsui, T.Takegami: Immunological profiles of the CSF from the anti-NMDA receptor
encephalitis patient., XXI World Congress of Neurology, (Vienna, '13.09).

7100I006

K.Iwai, T.Morita, O.Iritani, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF and HMGA1 opposite directionallyregulate the gene expression of microRNAs at scaffold/matrix-attachment regions in the arterial smooth muscle
cell, American Heart Association Scientific sessions 2013, (Dallas, '13.11).

7100I007

K.Tanaka, M.Matsui, M.Tanaka: Autoantibodies other than anti-AQP4 antibodies in seronegative NMO patients,
6th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis., (kyoto, '13.11).

7100I008

M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada,
M.Matsui: Intractable Cough May Be Characteristic Symptom of Neuromyelitis Optica, 6th Congress of the PanAsian Committee for Treatment and Research in Multiple Sclerosis., (kyoto, '13.11).

7100I009

T.Takegami, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Tasaki: Pathogenicity of Japanese Encephalitis Virus(JEW)
Newly Isolated in Ishikawa /Japan , and Analysis of Gene Expression in JEW-infected Cells, 3rd World Congress
on Virology, (Baltimore, '13.11).

－ 108 －

7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor(Additional Post)

MATSUI Shinobu

Clinical cardiology

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

NIIDA Yo

Genetic disease, Genetic diagnosis

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine

Senior Assistant Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Research Associate

MURANO Hidekazu

Cardial histology and immunohistochemistry

Researcher

TATSUNO Takanori

chemical biology

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype

Outline of Research
１．Heart failure by autoimmune pathway related with G-protein
２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
３．The role of AGE in the prevention of lifestyle related disease
４．Clinical research for the diagnosis and treatment of pancreatic cancer
５．Development and clinical application of fetal DNA diagnosis using mother’s blood
６．Genetic diagnosis and analysis of hereditary developmental disability
７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Publications
Originals
7200B001(A.Ojima), Y.Ishibashi, T.Matsui, S.Maeda, Y.Nishino, M.Takeuchi, K.Fukami, S.Yamagishi: Glucagon-like
peptide-1 receptor agonist inhibits asymmetric dimethylarginine generation in the kidney of streptozotocin-induced
diabetic rats by blocking advanced glycation end product-induced protein arginine methyltranferase-1 expression.,
Am. J. Pathol., 182:132-141, 2013.

－ 109 －

7200B002(Y.Ishibashi), T.Matsui, K.Ohta, R.Tanoue, M.Takeuchi, K.Asanuma, K.Fukami, S.Okuda, K.Nakamura,
S.Yamagishi: PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation., Microvasc. Res.,
85:54-58, 2013.

7200B003(Y.Fukushima), H.Daida, T.Morimoto, T.Kasai, K.Miyauchi, S.Yamagishi, M.Takeuchi, T.Hiro, T.Kimura,
Y.Nakagawa, M.Yamagishi, Y.Ozaki, M.Matsuzaki: Relationship between advanced glycation end products andplaque progression in patients with acute coronary syndrome: The JAPAN-ACS sub-study., Cardiovasc Diabetol.,
12:5, 2013.

7200B004

N.Nakaya, Y.Ishigaki, H.Nakajima, M.Murakami, T.Shimasaki, T.Takata, M.Ozaki, NJ.Dusetti, JL.Iovanna,
Y.Motoo: Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabinesensitivity., Mol Clin Oncol., 1:100-104, 2013.

7200B005(A.Kitano), T.Shimasaki, Y.Chikano, M.Nakada, M.Hirose, T.Higashi, Y.Ishigaki, Y.Endo, T.Takino, H.Sato, Y.Sai,
K.Miyamoto, Y.Motoo, K.Kawakami, T.Minamoto: Aberrant glycogen synthase kinase 3β is involved in pancreaticcancer cell invasion and resistance to therapy., PLoS ONE, 8:e55289;1-12, 2013.

7200B006(K.Yamanaka), M.Saito, M.Kita, Y.Takamura, G.Hashiguchi, H.Takabayashi, E.Tamiya: A single cell genedetection using micro-tweezers and the microchamber polymerase chain reaction for the fetal DNA analysis., Sens.
Actuators. B. Chem., 178:678-682, 2013.

7200B007(Y.Yano), M.Hayakawa, K.Kuroki, H.Ueno, S.Yamagishi, M.Takeuchi, T.Eto, N.Nagata, M.Nakazato, K.Shimada,
K.Kario: Nighttime blood pressure, nighttime glucose values, and target-organ damages in treated type 2 diabetes
patients., Atherosclerosis, 227:135-139, 2013.

7200B008(N.Tahara), S.Yamagishi, M.Takeuchi, A.Tahara, K.Kaifu, S.Ueda, S.Okuda, T.Imaizumi: Serum levels of advanced
glycation end products (AGEs) are independently correlated with circulating levels of dipeptidyl peptidase-4 (DPP4) in humans., Clin. Biochem., 46:300-303, 2013.

7200B009(S.Shoji), M.Inaba, N.Tomosugi, S.Okuno, M.Ichii, T.Yamakawa, S.Kurihara: Greater potency of darbepoetin-αthan erythropoietin in suppression of serum hepcidin-25 and utilization of iron for erythropoiesis in hemodialysis
patients., Eur. J. Haematol., 90:237-244, 2013.

7200B010

Y.Niida, A.Wakisaka, T.Tsuji, H.Yamada, M.Kuroda, Y.Mitani, A.Okumura, A.Yokoi: Mutational analysis of TSC1
and TSC2 in Japanese patients with tuberous sclerosis complex revealed higher incidence of TSC1 patients thanpreviously reported., J. Hum. Genet., 58:216-225, 2013.

7200B011(M.Yano), T.Yamamoto, N.Nishimura, T.Gotoh, K.Watanabe, K.Ikeda, Y.Garan, R.Taguchi, K.Node, T.Okazaki,
Y.Oike: Increased oxidative stress impairs adipose tissue function in sphingomyelin synthase 1 null mice., PLoS
ONE, 8:e61380;1-12, 2013.

7200B012(S.Maru), Y.Ishigaki, N.Shinohara, T.Takata, N.Tomosugi, K.Nonomura: Inhibition of mTORC2 but not mTORC1
up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2α expression in human renal cell
carcinoma., J. Urol., 189:1921-1929., 2013.

7200B013(Y.Ishibashi), T.Matsui, M.Takeuchi, S.Yamagishi: Metformin inhibits advanced glycation end products (AGEs)induced growth and VEGF expression in MCF-7 breast cancer cells by suppressing AGEs receptor expression via
AMP-activated protein kinase., Horm. Metab. Res., 45:387-390, 2013.

7200B014

N.Hayashi, J.George, M.Takeuchi, A.Fukumura, N.Toshikuni, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived
advanced glycation end-products promote alcoholic liver disease., PLoS ONE, 8:e70034;1-14, 2013.

7200B015(K.Fukami), S.Yamagishi, K.Kaifu, T.Matsui, Y.Kaida, S.Ueda, M.Takaeuchi, K.Asanuma, S.Okuda: Telmisartan
inhibits AGE-induced podocyte damage and detachment., Microvasc. Res., 88:79-83, 2013.

7200B016(S.Maeda), T.Matsui, M.Takeuchi, S.Yamagishi: Sodium-glucose cotransporter 2-mediated oxidative stressaugments advanced glycation end products-induced tubular cell apoptosis., Diabetes Metab. Res. Rev., 29:406412, 2013.

7200B017

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

－ 110 －

7200B018(T.Fujiwara), T.Ikeda, Y.Nagasaka, Y.Okitsu, Y.Katsuoka, N.Fukuhara, Y.Onishi, K.Ishizawa, R.Ichinohasama,
N.Tomosugi, H.Harigae: A low-molecular-weight compound K7174 represses hepcidin: possible therapeuticstrategy against anemia of chronic disease., PLoS ONE, 8:e75568;1-13, 2013.

7200B019(Y.Kaida), K.Fukami, T.Matsui, Y.Higashimoto, Y.Nishino, N.Obara, Y.Nakayama, R.Ando, M.Toyonaga, S.Ueda,
M.Takeuchi, H.Inoue, S.Okuda, S.Yamagishi: DNA aptamer raised against AGEs blocks the progression ofexperimental diabetic nephropathy, Diabetes, 62:3241-3250, 2013.

7200B020(R.Ando), S.Ueda, S.Yamagishi, H.Miyazaki, Y.Kaida, K.Kaifu, M.Yokoro, Y.Nakayama, N.Obara, K.Fukami,
M.Takeuchi, S.Okuda: Involvement of advanced glycation end product-induced asymmetric dimethylarginine
generation in endothelial dysfunction., Diab Vasc Dis Res., 10:436-441, 2013.

7200B021(SNJ.Song), M.Iwahashi, N.Tomosugi, K.Uno, J.Yamana, S.Yamana, T.Isobe, H.Ito, H.Kawabata, K.Yoshizaki:
Comparative evaluation of the effects of treatment with tocilizumab and TNF-α inhibitors on serum hepcidin,
anemia response and disease activity in rheumatoid arthritis patients., Arthritis Res. Ther., 15:R141;1-10, 2013.

7200B022(K.Kasahara), M.Kaneda, T.Miki, K.Iida, N.Sekino-Suzuki, I.kawashima, H.Suzuki, M.Shimonaka, M.Arai, Y.OhnoIwashita, S.Kojima, M.Abe, T.Kobayashi, T.Okazaki, M.Souri, A.Ichinose, N.Yamamoto: Clot retraction ismediated by factor XIII-dependent fibrin-αIIbβ3-myosin axis in platelet sphingomyelin-rich membrane rafts.,
Blood, 122:3340-3348, 2013.

7200B023(K.Sakata), M.Hayakawa, Y.Yano, N.Tamaki, N.Yokota, T.Eto, R.Watanabe, N.Hirayama, T.Matsuo, K.Kuroki,
S.Sagara, O.Mishima, M.Koga, N.Nagata, Y.Nishino, K.Kitamura, K.Kario, M.Takeuchi, S.Yamagishi: Efficacy ofalogliptin, a dipeptidyl peptidase-4 inhibitor, on glucose parameters, the activity of the advanced glycation end
product(AGE) - receptor for AGE(RAGE) axis, and albuminuria in Japanese type 2 diabetes., Diabetes Metab. Res.
Rev., 29:624-630, 2013.

7200B024(L.Dong), Y.Chen, Y.Masaki, T.Okazaki, H.Umehara: Possible mechanisms of lymphoma development in Sjöguren's
syndrome., Curr. Immunol. Rev., 9:13-22, 2013.

7200B025(N.Sugimoto), K.Matsuzaki, H.Ishibashi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami, Y.Masaki, T.Okazaki,
J.Sekine, S.Koizumi, A.Yachie, H.Umehara, O.Shido: Upregulation of aquaporin expression in the salivary glands ofheat-acclimated rats., Sci Rep, 3:1763;1-8, 2013.

7200B026

T.Arisawa, T.Tahara, H.Shiroeda, K.Yamada, T.Nomura, H.Yamada, R.Hayashi, K.Matsunaga, T.Otsuka,
M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata: Functional promoter polymorphisms of NFKB1
influence susceptibility to the diffuse type of gastric cancer., Oncol. Rep., 30:3013-3019, 2013.

7200B027

K.Takeda, T.Takata, Y.Kawai, Y.Ishigaki, K.Kajinami: Chk1-mediated phosphorylation of receptor-associated latetransducer at serine 250 increases its stability by stimulating its interaction with 14-3-3., Genes Cells, 18:369386, 2013.

7200B028(H.Muramoto), H.Mutoh, M.Takeuchi: Serum levels of advanced glycation end-products (AGEs) in dialysis patients-Effects of low-dose sevelamer hydrochloride-, J. Jpn. Soc. Dial. Ther., 46:467-473, 2013 (in Japanese) .

7200B029(R.Ozaki), H.Oda, R.Usuda, Y.Kumazawa, N.Kato, M.Kita, H.Takabayashi: Automatic Detection of Nucleated Red
Blood Cells from Microscope Images using Cell-Hog Feature, Journal of the Japan Society of Precision
Engineering., 79:1074-1077, 2013 (in Japanese) .

Reviews
7200C001

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi:
Significance of Kampo, traditional Japanese medicine, in supportive care of cancer patients., Evid BasedComplement Alternat Med, 2013,746486;1-10, 2013.

7200C002

J.Yamakawa, J.Moriya, K.Takeuchi, M.Sawada, Y.Motoo, J.Kobayashi: Significance of kampo, japanese traditional
medicine, in the treatment of obesity:basic and clinical evidence., Evid Based Complement Alternat Med,2013,943075;1-8, 2013.

7200C003

J.Yamakawa, Y.Motoo, J.Moriya, M.Ogawa, H.Uenishi, S.Akazawa, T.Sasagawa, M.Nishio, J.Kobayashi: Role ofKampo medicine in integrative cancer therapy., Evid Based Complement Alternat Med, 2013:570848;1-6, 2013.

－ 111 －

Case Reports
7200D001

Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Japanese variant of multicentirc cattleman's disease associatedwith serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a
distinct clinicopathological entity?, J. Clin. Exp. Hematop., 53:79-85, 2013.

7200D002

I.Chikazawa, D.Nakai, K.Miyazawa, T.Tanaka, K.Suzuki, K.Sato, Y.Motoo: Neuroendcrine carcinoma of theprostate treated combined modality therapy., Jpn. J. Cancer Clin., 59：99-104, 2013 (in Japanese) .

7200D003

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo: A case of leg pain associated with lumber spinal canal stenosis inpatient with Parkinson disease treated by yokukansan., Pain and kampo medicine., 23:114-117, 2013 (inJapanese) .

7200D004

K.Kojima, T.Fujii, A.Nishibu, T.Mochizuki, Y.Niida: A Case of hereditary angioederma with blisters., Skin
research, 12:190‐194, 2013 (in Japanese) .

Short Communications
7200E001(Y.Ebata), J.Takino, H.Tsuchiya, T.Sakabe, Y.Ikeda, S.Hama, K.Kogure, M.Takeuchi, G.Shiota: Presence ofglyceraldehyde-derived advanced glycation end-products in the liver of insulin-resistant mice, Int. J. Vitam. Nutr.
Res., 83:137-141, 2013.

7200E002(Y.Higashimoto), T.Matsui, Y.Nishino, J.Taira, H.Inoue, M.Takeuchi, S.Yamagishi: Blockade by phosphorothioate
aptamers of advanced glycation end products-induced damage in cultured pericytes and endothelial cells.,
Microvasc. Res., 90:64-70, 2013.

Others
7200F001

N.Hayashi, H.Okuyama, Y.Matsui, H.Yamaya, E.Kinoshita, H.Minato, Y.Niida, H.Yokoyama: Adult-onset renal
failure in a family with Alagille syndrome with proteinuria and a novel JAG1 mutation., Clin Kidney J, 6:295-299,
2013.

7200F002(T.Suzuki), K.Toba, K.Kato, T.Ozawa, M.Higasimura, T.Kitajima, H.Oda, K.Tsuchida, N.Tomosugi, H.Saitoh,
Y.Aizawa: Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction
who underwent successful percutaneous coronary intervention., Int. J. Cardiol., 167:286-288, 2013.

7200F003(T.Suzuki), K.Toba, K.Kato, T.Ozawa, H.Suzuki, N.Tomosugi, H.Saitoh, Y.Aizawa: Effects of erythropoietin
administration on iron status in patients with ST-elevation myocardial infarction who underwent successful
percutaneous coronary intervention., Int. J. Cardiol., 167:1644-1645, 2013.

7200F004(N.Tahara), S.Yamagishi, A.Tahara, M.Takeuchi, T.Imaizumi: Asymmetrical dimethylarginine level is independently
associated with circulating levels of RAGE and PEDF, Int. J. Cardiol., 167:3072-3074, 2013.

7200F005(S.Schröder), S.Lee, T,Efferth, Y.Motoo: Acupuncture and herbal medicine for cancer patients., Evid BasedComplement Alternat Med, 2013:313751;1-5, 2013.

Presentations at Conference
International Conference (Key Note Lecture)
7200G001

T.Okazaki: The mechanism to overcome the chemoresistance of leukemia cells through autophagic cell death,International congress Cancer Cell Death and Resistance, (Toulouse, '13.05).

7200G002

T.Okazaki: Regulation of Malignant Cell Proliferation and Migration through SM in Plasma Membrane, International
Conference of the Korean Society for Molecular and Cellular Biology, (Seoul, '13.10).

－ 112 －

International Conference (Presentations)
7200I001

J.Moriya, J.Yamakawa, J.Kobayashi, Y.Motoo: Successful Treatment with Kampo Medicine for Chronic Fatigue
Syndrome: a Case Report, 2nd International symposium for Japanese Kampo Medicine, (London, UK, '13.04).

7200I002

T.Shimasaki, Y.Ishigaki, A.Kitano, T.Takata, T.Arisawa, N.Ueda, T.Kosaka, T.Takegami, Y.Motoo, N.Tomosugi,
T.Minamoto: Glycogen synthase kinase 38 inhibition sensitizes pancreatic cancer to gemcitabine., Digestive
Disease Week 2013, (Orlando, '13.05).

7200I003

J.George, N.Hayashi, M.Takeuchi, T.Arisawa, M.Tsutsumi: Acetaldehyde-derived advanced glycation endproducts promote alcholic liver disease., Digestive Disease Week 2013, (Orlando, '13.05).

7200I004(Y.Nakayama), K.Fukami, S.Yamagishi, Y.Kaida, R.Ando, N.Obara, M.Takeuchi, S.Ueda, S.Okuda: Lanthanum
suppresses AGEs-induced osteoblastic differentiation via inhibition of RAGE-ROS-NF-kB pathway in rat vascularsmooth muscle cells, ERA-EDTA 2013, (Istanbul, '13.05).

7200I005

M. Taniguchi, K. Kitatani, Y. Taguchi, T. Takegami, H. Umehara, T. Okazaki: Sphingosine-1-phosphate lessens
ceramide-mediated cell death in IL-2 deprived natural killer cells, FASEB Science Research Conference, (Niseko,'13.08).

7200I006

T.Kawanami, T.Takata, H.Iwao, Y.Masaki, H.Shimizu, T.Sato, T.Nakamura, A.Nakajima, M.Miki, Y.Fujita,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Proteomics analysis in IgG4-related disease, 12th International
Symposium on Sjögren's Syndrome, (Kyoto, '13.10).

7200I007

A.Nakajima, Y.Masaki, T.Nakamura, T.Kawanami, H.Shimizu, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita,
M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Analysis of CLC and MS4A3 gene expression in perioheral bloodmononuclear cells from patients with IgG4-related disease, 12th International Symposium on Sjögren's Syndrome,(Kyoto, '13.10).

7200I008

T. Arisawa, T. Tahara, M. Nakamura, H. Yamada, T. Nomura, R. Hayashi, K. Matsunaga, N. Kawada, T. Otsuka,
T. Shimasaki, N. Toshikuni, H. Shiroeda, T. Shibata: GENETIC POLYMORPHISM OF MYD88 GENE (RS7744) IS
CLOSELY ASSOCIATED WITH THE SUSCEPTIBILITY TO ULCERATIVE COLITIS, 21th United European
Gastroenterology Week, (Berlin, Germany, '13.10).

7200I009

T. Ueda: Lipid droplets are derived from mitochondria in cultured cardiomyocytes, 2013 ASCB annual meeting,(New Orleans, '13.12)，2013 Annual Meeting Poster Guide The American Society for Cell Biology, 97p, 2013.

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7310

Division of Innovative Research

Title

Name

Field of Specialization

Professor(Additional Post)

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate
Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Postdoctoral Researcher

MATSUDA Yukihisa

Cognitive psychology，Brain science

Postdoctoral Researcher

WANG Min

Neurophysiology

Faculty

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
7310B001(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women, Endocrinology, 170:131-139, 2013.

7310B002(R.Sato), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, Y.Suwazono: Twenty-two-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan., Open J
Nephrol., 3:205-210, 2013.

7310B003(A.Takeuchi), Y.Yamamoto, S.Munesue, A.Harashima, T.Watanabe, H.Yonekura, H.Yamamoto, H.Tsuchiya: Low
molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression ofmalignant phenotype in human fibrosarcoma cells., Cancer Sci., 104:740-749, 2013.

7310B004

A.T.N.Nguyen, M.Nishijo, E.Hori, N.M.Nguyen, T.T.Pham, K.Fukunaga, H.Nakagawa, A.H.Tran, H.Nishijo:
Influence of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on socioemotional behaviors in offspringrats., Environ Health., 7:1-14, 2013.

7310B005(MN.Nguyen), M.Nishijo, ATN.Nguyen, A.Bor, T.Nakamura, E.Hori, H.Nakagawa, T.Ono, H.Nishijo: Effects ofmaternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on parvalbumin-and calbindin-immunoreactive neurons
in the limbic system and superior colliculus in rat offspring., Toxicology, 314:125-134, 2013.

7310B006(S.Munesue), Y.Yamamoto, R.Urushihara, K.Inomata, H.Saito, S.Motoyoshi, T.Watanabe, H.Yonekura,
H.Yamamoto: Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of
RAGE trafficking to lipid rafts., Food Funct., 4:1835-1842, 2013.

7310B007(H.D.Manh), T.Kido, R.Okamoto, S.X.Liang, N.H.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, D.V.Tung, D.D.Nhe, N.N.Hung, L.K.Son: The relationship between dioxins and salivary
steroid hormones in Vietnamese primiparae., Environ. Health Prevent. Med., 18:221-229, 2013.

－ 114 －

7310B008

PT.Tai, M.Nishijo, N.Thi Nguyet Anh, S.Maruzeni, H.Nakagawa, H.Van Luong, T.Hai Anh, R.Honda, T.Kido,
H.Nishijo: Dioxin exposure in breast milk and infant neurodevelopment in Vietnam., Occup. Environ. Med.,
70:656-662, 2013.

7310B009(S.Satarug), W.Swaddiwudhipong, W.Ruangyuttikarn, M.Nishijo, P.Ruiz: Modeling cadmium exposures in low- andhigh-exposure areas in Thailand., Environ. Health Perspect., 121:531-536, 2013.

7310B010

M.Nishijo, TN.Nghi, HD.Manh, PT.Tai, NTN.Anh, PHA.Vu, NT.Nguyen, NX.Hung, HM.Hoan, HC.Hai, H.Nishijo,
T. Hai-Anh, HV.Luong, T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Dioxin concentration in breast milk ofprimipara mothers in Bien Hoa, a hot spot area in Vietnam －A preliminary study in 2012－., Organohalogen
Compounds., 75:1167-1170, 2013.

7310B011(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV.Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., Organohalogen Compounds., 75:1321-1324, 2013.

7310B012(HD.Manh), T.Kido, R.Okamoto, XL.Sun, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: Current elevated dioxin level in serum of Vietnamese old men: Past exposure or
current exposure., Organohalogen Compounds., 75:1316-1320, 2013.

7310B013(XL.Sun), T.Kido, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: The relationship between dioxin and steroid hormones in serum of Vietnamese men.,
Organohalogen Compounds., 75:314-317, 2013.

7310B014(T.Koyama), S.Yamamoto, K.Yoshida, Y.Arai, M.Sakurai, K.Nakamura, M.Nishijyo, Y.Nakanishi, S.Nagasawa,
Y.Morikawa, M.Tabata, H.Nakagawa: Calcium intake and associated other dietary factors in healthy enderly
people., Hokuriku Japanese Journal of Public Health., 40:6-13, 2013 (in Japanese) .

Others
7310F001(H.Teranishi), M.Nishijo: Environmental Cadmium Conference 2013: Health risk of environmental cadmium
contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M, Ruangyuttikarn W eds) Lessons
from itai-itai disease and cadmium pollution in Japan, Chiang Mai University, 4-8, 2013.

7310F002

M.Nishijo, S.Maruzeni, K.Nakamura, H.Nakagawa: Environmental Cadmium Conference 2013: Health risk ofenvironmental cadmium contamination in MaeSot, Tak Province, Thailand & related subjects (Nishijo M,
Ruangyuttikarn W eds) Mortality of itai-itai disease patients and residents in a Cd polluted Jinzu River basin,
Toyama, Japan, Chiang Mai University, 9-14, 2013.

Presentations at Conference
International Conference (Presentations)
7310I001

Y.Matsuda, T.Shimada, Y.Kawasaki: Local cortical gyrification of the insula in schizophrenia:Statisticalcharacteristics and its visualization., 11th World Congress of Biological Psychiatry, (Kyoto Japan, '13.06).

7310I002

T.Shimada, Y.Matsuda, A.Monkawa, R.Hashimoto, H.Kihara, K.Watanabe, Y.Kawasaki: Relationship between thebrain structure function and social functioning in the patients with schizophrenia, 11th World Congress ofBiological Psychiatry, (Kyoto Japan, '13.06).

7310I003(R.Tagawa), H.Hashimoto, A.Nakanishi, Y.Kawarada, T.Muramatsu, Y.Matsuda, S.Higashiyama, J.Kawabe, T.Kai,
K.Inoue: The relationship between medial temporal lobe atrophy and cognitive impairment in patients withdementia with lewy bodies, 11th World Congress of Biological Psychiatry, (Kyoto Japan, '13.06).

7310I004(Y.Tatebayashi), N.Kikuchi, Y.Hayashi, T.Itou, T.Shinozaki, Y.Matsuda: Abnormal fatty acid composition in thefron-topolar cortex of patients with mood disorders, 11th World Congress of Biological Psychiatry, (Kyoto Japan,'13.06).

－ 115 －

7310I005

Y.Kawasaki, R.Hashimoto, S.Ono, T.Shimada, H.Kihara, Y.Matsuda, M.Tunoda: Early detection and intervention
project for young people at risk for developing psychosis Uchinada, 21st World Congress Social Psychitry,(Lisbon,Portugal, '13.07).

7310I006

M.Nishijo, TN.Nghi, HD.Manh, PT.Tai, NTN.Anh, PHA.Vu, NTNguyen., NX.Hung, HM.Hoan, HC.Hai, H.Nishijo,
T.Hai-Anh, HV.Luong, T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Dioxin concentration in breast milk ofprimipara mothers in Bien Hoa, a hot spot area in Vietnam － A preliminary study in 2012－., The 33rd
international Symposium on Halogenated Persistent Organic pollutants - Dioxin 2013, (Daegue, Korea, '13.08).

7310I007(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV. Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LKSon., Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., The 33rd international Symposium on Halogenated Persistent Organic pollutants Dioxin 2013, (Daegue, Korea, '13.08).

7310I008

Y.Matsuda, T.Shimada, T.Monkawa, A.Monkawa, K.Watanabe, Y.Kawasaki: Curvature of the temporal pole inpatients with schizophrenia: Statistical characteristics and its visualization., International Conference on Basic andClinical Multimodal Imaging, (Geneva,Switzerland, '13.09).

7310I009

T.Shimada, Y.Matsuda, R.Hashimoto, T.Monkawa, A.Monkawa, K.Watanabe, Y.Kawasaki: Relationship between
the brain structure and social functioning in the patients with schizophrenia, International Conference on Basic andClinical Multimodal Imaging, (Geneva, Switzerland, '13.09).

7310I010

R.Hashimoto, Y.Matsuda, M.Kawahara, F.Kitamoto, Y.Kawasaki: Usability of Self-Other Focused Thinking Error
Scale(SOFT)for clinical patients, 43rd Annual Congress European Association for Behavioural and Cognitive
Therapies., (Marrakech,Morocco, '13.09).

－ 116 －

7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Assistant
Professor(Additional Post)

HATSUSAKA Natsuko ophthalmological optics

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, "glaucoma, age related maculardegeneration", "JICA, WHO, outdoor temperature, risk factors search", "Reykjavik eye study, Monzen eye study","Liaoning eye study, racial differences"

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
7320B001

E.Kubo, N.Hasanova, N.Fatma, H.Sasaki, DP.Singh: Elevated tropomyosin expression is associated with epithelialmesenchymal transition of lens epithelial cells., J. Cell. Mol. Med., 17:212-221, 2013.

7320B002(GM.Zoega), A.Arnarsson, H.Sasaki, PG.Soderberg, F.Jonasson: The 7-year cumulative incidence of cornea
guttata and morphological changes in the corneal endotheliu in the Reykjavik Eye Study., Acta Ophthalmol.
Scand., 91:212-218, 2013.

7320B003(T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki: FDTD analysis oftemperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45
GHz., Radiat Prot Dosimetry, 155:284-291, 2013.

7320B004

E.Kubo, N.Hasanova, H.Sasaki, DP.Singh: Dynamic and differential regulation in the microRNA expression in thedeveloping and mature cataractous rat lens., J. Cell. Mol. Med., 17:1146-1159, 2013.

7320B005(Y.Inoue), Y.Shimomura, M.Fukuda, D.Miyazaki, Y.Ohashi, H.Sasaki, Y.Tagawa, H.Shiota, N.Inada, S.Okamoto,K.Araki-Sasaki, T.Kimura, H.Hatano, H.Nakagawa, S.Nakamura, A.Hirahara, K.Tanaka, H.Sakuma: Multicentre
clinical study of the herpes simplex virus immunochromatographic assay kit for the diagnosis of herpetic epithelial
keratitis., Br. J. Ophthalmol., 97:1108-1112, 2013.

－ 117 －

7320B006(A.Arnarsson), H.Sasaki, F.Jonasson: Twelve-year incidence of exfoliation syndrome in the Reykjavik eye study.,
Acta Ophthalmol., 91:157-162, 2013.

7320B007

M.Fukuda, S.Shibata, N.Shibata, K.Hagihara, H.Osada, N.Takahashi, E.Kubo, H.Sasaki: Safety comparison of
additives in antiglaucoma prostaglandin (PG) analog ophthalmic formulations., Clin. Ophthalmol., 7:515-520, 2013.

7320B008

M.Sasaki, M.Takahashi, E.Shibuya, A.Okamoto, N.Mita, Y.Takahashi, E.Kubo, H.Sasaki: Corrected near andintermediate vfisual acuity in eyes with aspheric mono focal intraocular lens., The Journal of the Japanese Society
for Cataract Research, 25:61-64, 2013 (in Japanese) .

7320B009

M.Fukuda, H.Nakashima, J.Haruta, S.Shibata, N.Shibata, H.Osada, Y.Seki, N.Mita, H.Sasaki: Safety of rebamipide
ophthalmic suspension for corneal epithelial cells: In vitro and In vivo study., Journal of the eye., 30:1467-1471,
2013 (in Japanese) .

7320B010(N.Ibaraki), E.Kubo, H.Sasaki: Cases in which prescribed glaucoma medications were unnecessary., Journal of theeye., 30:1472-1474, 2013 (in Japanese) .

Reviews
7320C002

H.Sasaki: Prevalence of cataract, Ophthalmology, 55:227-233, 2013 (in Japanese) .

7320C003

H.Sasaki: Risk Factors of Age-related cataract, The Journal of the Japanese Society for Cataract Research, 25:917, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
7320I001

E.Kubo, N.Hasanova, H.Osada, E.Kiyokawa, H.Sasaki, F.Nigar, S.Dhirendra: FGF2 Antagonizes the TGFβ2induced aberrant expression of tropomuosin and α-smooth muscle actin in mouse and human lens epithelial cells
and has a role in posterior capsule opacity, The Association for Research in Vision and Ophthalmology, (Seattle,'13.05).

7320I002

M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki: Difference in ocular damage by 40 and 95 GHz exposure to rabbit eye,
The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

7320I003

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, M.Takahashi, Y.Takahashi, H.Osada, K.Sasaki, E.Kubo:
Correlating visual function and size of area opacifid by retrodots based on retroillumination photography, The
Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

7320I004(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, K.Sasaki, H.Sasaki: Factors influencing visual function in eyes withretrodots by difference in size, The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

7320I005(T.Kawamorita), H.Uozato, H.Sasaki, Y.Shibata, M.Kanazawa, M.Hirota, Y.Jang, S.Arai, K.Shimizu: Schematic eyemodel based on the regression of age-dependent changes of the erystalline lens, The Association for Research in
Vision and Ophthalmology, (Seattle, '13.05).

7320I006

N.Hatsusaka, K.Sasaki, H.Sasaki: A comparison between casey eye institute (CEI) camera system and the EAS1000 camera in recording retro-dot opacities, The Association for Research in Vision and Ophthalmology, (Seattle,'13.05).

7320I007

M.Takahashi, H.Osada, N.Mita, E.Shibuya, N.Hatsusaka, Y.Takahashi, Y.Sakamoto, K.Sasaki, E.Kubo, H.Sasaki:
Contrast acuity in eyes with different types of lens opacity, The Association for Research in Vision andOphthalmology, (Seattle, '13.05).

7320I008

Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, E.Shibuya, E.Kubo, H.Sasaki: Optical simulation for subsurface nano glistening, The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

7320I009

A.Arimoto, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki, K.Kitagawa: Evaluation of the effect of rebamipide
ophthalmic suspension on the signs and symptoms of keratoconjunctivitis sicca in Sjogren's syndrome patients withor without punctal occlusions, 12th International Symposium on Sjogren's Syndrome, (Kyoto, '13.10).
－ 118 －

7320I010(J.Chakarothai), Y.Suzuki, M.Taki, K.Wake, Kensuke Sasaki, S.Watanabe, M.Kojima: Analysis of millimeter-wave
exposure on rabbit eye using a hybrid PMCHWT-MoM-FDTD method, 2013 International Symposium on Antennas
and Propagation, (China, '13.10).

7320I011

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, K.Sasaki, E.Kubo: Retrodot-opaque-area and visualfunction, American Academy of Ophthalmology, (shiatosru, '13.11).

7320I012

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy of Electromagnetic Fields,(Washington, '13.11).

7320I013

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy on RF Electromagnetic
Fields, (Washingto, '13.11).

7320I014

M.Kojima, T.Okuno, D.Sliney: Animal studies of infrared cataract review of anial studies and discussions wolbarsht
and pitts studies (photochemical?) review of gldman and vogt experiments, The 2013 Baltimore optical Radiation
Workshop, (Baltimore, '13.12).

7320I015

H.Sasaki, M.Kojima, K.Sasaki: Epidemiological studies of caract with latitude -evdence for a thermal factor-, The
2013 Baltimore optical Radiation Workshop, (Baltimore, '13.12).

－ 119 －

7330

Division of Dermatomycology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Assistant
Professor(Additional Post)

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Publications
Originals
7330B001
7330B002(R.Kano), M. Isizuka, M.Hiruma, T.Mochizuki, H.Kamata, A.Hasegawa: Mating type gene(MAT1-1)in Japaneseisolates of Trichophyton rubrum, Mycopathologia, 175:171-173, 2013.
(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Hiruma: Urease gene of Trichophyton rubrum var.

raubitschekii, J. Dermatol., 40:111-113, 2013.
7330B003(R.Kano), K.Anzawa, T.Mochizuki, K.Nishimoto, M.Hiruma, H.Kamata, A.Hasegawa: Sporothrix schenckii(sensu
strict S.globosa) mating type 1-2(MAT1-2) gene., J. Dermatol., 40:726-730, 2013.

7330B004

T.Mochizuki, K.Anzawa, Y.Sakata, M.Fujihiro: Simple identification of Trichophyton tonsurans by chlamydosporelike structures produced in culture media., J. Dermatol., 40:1027-1032, 2013.

7330B005(H.Kobayashi), M.Yoshioka, K.Anzawa, T.Mochizuki: Cases of Microsporum canis infection between 2005 and2011 in a dermatology clinic in the southern part of Kanazawa city., Skin research, 12:219-223, 2013 (inJapanese) .

7330B006

Y.Sakata, T.Sakamoto, A.Kitayama, T.Ushigami, K.Anzawa, T.Fujii, S.Abe, A.Nishibu, T.Mochizuki: Mass
screenings for Trichophyton tonsurans infection in junior high school judo teams in Ishikawa prefecture, Japan.,
Journal of Pediatric Dermatology., 32:121-126, 2013 (in Japanese) .

7330B007

T.Mochizuki, S.Abe, H.Tanabe, T.Ushigami, K.Kojima, M.Nanbu, T.Sakamoto, J.Kawanishi, J.Hatta, K.Anzawa,
T.Nakamura, N.Yoshida, K.Ogawa: Efficacy of IKD-382 cream for tinea pedis with hyperkeratotic lesions.,
Nishinihon j. dermatol., 75:454-459, 2013 (in Japanese) .

－ 120 －

Case Reports
7330D001

M.Hasei, K.Takeda, K.Anzawa, A.Nishibu, H.Tanabe, T.Mochizuki: Case of phaeohyphomycosis producing
sporotrichoid lesions., J. Dermatol., 40:638-640, 2013.

7330D002(H.Amano), C.Kishi, Y.Yokoyama, A.Shimizu, K.Anzawa, T.Mochizuki, O.Ishikawa: Microsporum canis infection
mimics pemphigus erythematosus., Indian J Dermatol., 2013;58:243, 2013.

7330D008

K.Kojima, T.Fujii, A.Nishibu, T.Mochizuki, Y.Niida: A Case of hereditary angioederma with blisters., Skin
research, 12:190‐194, 2013 (in Japanese) .

7330D010(A.Kawakita), A.Tanizawa, K.Suzuki, I.Hata, H.Takahashi, M.Kumakiri, K.Anzawa, T.Mochizuki, Y.Ohshima:
Disseminated Fusarium infection in a patient with acute lymphoblastic leukemia., Japanese Journal of PediatricHematology/Oncology, 50:624-628, 2013 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
7330H001

T.Mochizuki: Molecular diagnosis in mycosis -important for daily practice in dermatology clinics, The Scientific
Meeting and National Congress of“Crossing Boundaries: Mycology in the Study of Tropical Diseases in Indonesia,(Bandung, Indonesia, '13.06).

7330H002

T.Mochizuki: Prospect in the management of dermatomycoses in Japan, The Scientific Meeting and National
Congress of“Crossing BoundariesMycology in the Study of Tropical Diseases in Indonesia, (Bandung, Indonesia,'13.06).

International Conference (Presentations)
7330I001

T.Mochizuki, K.Anzawa, M.Fujihiro: Morphogenesis and species specificity of chlamydospore-like structures ofTrichophyton tonsurans , 2013 Congress of Asia Pacific Society for Medical Mycology, (Chengdu,China, '13.06).
7330I002(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Hiruma, S.Ikeda: Urease gene of Trichophyton
rubrum var. raubitschekii, 2013 Congress of Asia Pacific Society for Medical Mycology, (Chengdu,China, '13.06).

－ 121 －

School of Nursing

8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing

Associate Professor

SAKAI Keiko

Communication Skills

Associate Professor

MATSUI Yuko

Fundamental Nursing

Senior Assistant Professor

KYUJI Kazuyo

Nursing Students and Proffessional Sprit

Assistant Professor

OKAYAMA Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireAssistant Professor

FUKUDA Moriyoshi

Fundamental Nursing

Keywords of Researchfundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care

Outline of Research
1. Verification of nursing skills
3. Study of nursing education

Publications
Originals
8010B001

S.Maeda, T.Takiuti, T.Komatsu, Y.Kohno, K.Kyuji: Current status of long-term indwelling urinary catheter
management by visiting nurses., Int J of Urol Nurs, 7:76-84, 2013.

－ 122 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring

Senior Assistant Professor

KINOSHITA Sachiko

Wound Care, Stoma care, Continence care

Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Nursing Ethics, Terminal Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001(J.Matsuo), M.Fukuda, E.Iuchi, T.Nishizawa, M.Okuwa, J.Sugama, C.Konya, H.Sanada: Effects of differences in
bed making methods on air mattress pressure redistribution., J. Jpn. WOCM, 17:33-39, 2013 (in Japanese) .

Reviews
8040C001

C.Konya, Y.Mizokami, R.Kamide, K.Tokunaga, H.Sanada, G.Nakagami, H.Kataoka, S.Kinoshita, C.Konishi,
Y.Murooka: ABCD-Stoma care:A tool that assists clinicians' decision-making about basic skin care mased on the
ABCD-Stoma., J. Jpn. WOCM, 17:319-335, 2013 (in Japanese) .

－ 123 －

8050

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Associate Professor

KOIZUMI Yumi

community/elderly unrsing science

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8050B001

Y.Koizumi, Y.Hamazaki, M.Okuro, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association between
hypertension status and the screening test for frailty in elderly community-dwelling Japanise, Hypertens. Res.,
36:639-644, 2013.

－ 124 －

8060

Pediatric Nursing

Faculty
Title

Name

Associate Professor

MIYAUCHI Tamaki

Assistant Professor

TERAI Takahiro

Field of Specialization
Caring for Children with Chronic illness, Family Nursing in Child ＆Maternal Health Care
Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention

Presentations at Conference
International Conference (Presentations)
8060I001

T.Terai, T.Miyauchi: The Learning of Nursing Students Who Attended Clinical Practice, World Academy of
Nursing Science, (Seoul,Korea, '13.10).

8060I002

T.Miyauchi, T.Terai, A.Yokota: The practice of psychological preparation in child health nursing in Japan, World
Academy of Nursing Science, (Seoul,Korea, '13.10).

－ 125 －

8070

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

OCHIAI Fumie

Maternity Health, Child Health, Midwifery

Senior Assistant Professor

BODA Hitomi

Matenity Nursing，Midwifery

Senior Assistant Professor

IWATANI Kumiko

Matenity Nursing，Midwifery

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing

Assistant Professor

KITAHAMA Masami

Crinical Maternity Nursing

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

－ 126 －

8080

Community Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Associate Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse

Senior Assistant Professor

SAKURAI Shihomi

Public health nursing, Family nursing

School hygiene

Industrial health

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, activity of cmmunity organization, Nonsmoking education, School hygiene, Industrial health

Outline of Research
The community nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, and health maintenance.

Publications
Originals
8080B001

Y.Koizumi, Y.Hamazaki, M.Okuro, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association between
hypertension status and the screening test for frailty in elderly community-dwelling Japanise, Hypertens. Res.,
36:639-644, 2013.

8080B002

S.Sakurai, M.Hirai: The importance of home blood pressures in family caregivers of dementia patients who canwalk., Journal of Japan Academy of Home Care., 16:37-44, 2013 (in Japanese) .

8080B003(M.Konagaya), E.Kishi, S.Nomura, S.Yoshioka, Y.Nojiri, Y.Mochizuki, Y.Hamazaki, J.Yonezawa: Identifying thefactors underlying self-neglect of the elderly;from self-neglect acknowledged by professionals as requiring support.,
Journal of the Japan Academy for the Prevention of Elder Abuse, 9:54-63, 2013 (in Japanese) .

8080B005

M.Nakashima, Y.Morikawa, Y.Hamazaki, S.Sakurai, J.Kitagawa, M.Sakurai, H.Nakagawa: Total smoking ban on an
university campus and acquisition of smoking habits., Jpn J School Health, 55:396-401, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8080I001

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, M.Nakashima, H.Nakagawa: Relationship between houseboundstatus and onset of need for ling term care among the elderly in arural town, The 5th international conference oncommunity health nursing research, (Edinburgh UK, '13.03).

8080I002

S Sakurai, Y Kohno, M Hirai, N Sakurai, A Maekawa: Relationship Between Sleep Quality And Stress In Japanese
Family Caregivers An Investigation Using Objective And Subjective Date, 11th International Family Nursing
Conference, (Minesota ＵＳＡ, '13.06).

－ 127 －

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Professor

HASEGAWA Masami

Senior Assistant Professor

TANAKA Koji

Assistant Professor

NAGAYAMA Yutaka

Field of Specialization
depression, suicide prevention, therapeutic nursing, narrative
approachlife-world led care, patient-nurse interrelationship, empathy,
psychiatric and mental health nursing
Minimization for the action limitation, psychiatric nursing for acutephase

Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship,
empathy, psychiatric and mental health nursing, minimizing for the action limitation, physical restraint, seclusion, Emotion
Modulation Therapy

Outline of Research
The purpose of our study is to clarify the suicide prevention effect forthe depression people by Narrative approach and Emotion Modulation
Therapy(EMT). We are trｙing the effect of these methods as new
therapeutic nursing for depression people between our nursing clinic in
Japan and Griffth University clinic in Australia.

Publications
Originals
8085B001(K.Bando), M.Hasegawa: The process of maintenance dialysis in depressed patients on hemodialysis., J. Tsuruma
Health Sci. Soc., 37:15-22, 2013.

8085B002(M.Oe), M.Hasegawa: Nurses' management of a clubhouse model-based self-help group for people withdepression., J. Tsuruma Health Sci. Soc., 37:1-14, 2013.

8085B003(K.Nagata), M.Hasegawa: Analysis of emotions and conditions of depression person before and after their suicide
attempts - From the narrative by narrative approach -, Journal of Japan Academy of Psychiatric and Mental HealthNursing., 22:1-11, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8085I001

M.Hasegawa: Intervention for Depression Suicidal Behavior Patients with Emotion Modulation Therapy, World
Psychiatric Association Inter national Congress 2013, (Australia, '13.10).

－ 128 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
supportAssistant Professor

NAKAI Hisao

Home healthcare,Disaster Nursing,Care Management

Keywords of Research
Psychiatric Disorder, Community besed Workshop, "Recoverry"consept, psychatric service, Public health nursing
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced "Recoverry"consept, prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B001

S.Maeda, T.Takiuti, T.Komatsu, Y.Kohno, K.Kyuji: Current status of long-term indwelling urinary catheter
management by visiting nurses., Int J of Urol Nurs, 7:76-84, 2013.

Short Communications
8090E001

S.Maeda: Care related to supply of healthcare and hygiene materials to home care patients with intermittent selfcomparison between ambulatory care and at discharge-, Izai, 21:51-56, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8090I001

H.Nakai: Recognition of disaster preparedness of the people who need continuing health care at home - focusedon recognition of non-human and human environment -, 9th International Nursing Conference ＆ 3rd World
Academy of Nursing Science, (Seoul,Korea, '13.10)，9th International Nursing Conference ＆ 3rd World Academyof Nursing Science Abstracts Book, 150, 2013.

8090I002

S.Maeda, T.Takiuchi, T.Komatsu, Y.Kohno, H.Nakai: Evaluation of a long-term indwelling bladder-catheter
management training program for visiting nurses, International Nursing Conference & World Academy of Nursing
Science, (Souel,Korea, '13.10)，9th International Nursing Conference ＆ 3rd World Academy of Nursing Science
Abstracts Book, 134, 2013.

－ 129 －

8095

Comprehensive Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing, Paliative Care, Chronic
Disease Nursing

Keywords of Researchnephrology, nursing, chronic kidney disease, hemodialysis
nursing, cancer survivors, care development
nursing, live donor, transplants

Outline of Research
Development of A Care for Cancer Survivors
Development of A Care for Live Donor for Transplants
Development of A Care for Patients under Chronic Kidney Disease or Hemodialysis

Presentations at Conference
International Conference (Presentations)
8095I001

S.Tamura, K.Shintani: Initial Development of a Care System for Cancer Survivors Based on an Investigation Their
Actual Lifestyle Conditions, 24nd International Nursing Research Congress, (Prague, Czech Republic, '13.07)，"Honor Society of Nursing, Sigma Theta Tau International 24th International Nursing Research Congress", 41,
2013.

－ 130 －

8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Professor

OKADA Masato

Peripheral nerve surgery, Trauma

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Professor

HONDA Ryumon

Environment and health, Epidemiology

Associate Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Nicotine dependence and cost-effectiveness of individualized support for smoking cessation: evidence
from practice at a worksite in Japan., PLoS ONE, 8:e55836;1-9, 2013.

8100B002

Y.Koizumi, Y.Hamazaki, M.Okuro, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association between
hypertension status and the screening test for frailty in elderly community-dwelling Japanise, Hypertens. Res.,
36:639-644, 2013.

8100B003

Y.Morikawa, M.Sakurai, K.Nakamura, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Correlation
between shift-work-related sleep problems and heavy drinking in Japanese male factory workers., Alcohol Alcohol.,
48:202-206, 2013.

8100B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Sasaki, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, H.Nakagawa: Family histry of diabetes, lifestyle factors, and the 7-year incident risk oftype 2 diabetes mellitus in middle-aged Japanese men and women., J Diabetes Investig, 4:261-268, 2013.

－ 131 －

8100B005(R.Sato), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, Y.Suwazono: Twenty-two-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan., Open J
Nephrol., 3:205-210, 2013.

8100B006

T.Ishibashi, M.Nomura-Nakamoto, F.Abe, T.Masuoka, N.Imaizumi, J.Yoshida, Tomie Kawada, M.Nishio: Effects ofcyanamide, an aldehyde dehydrogenase type2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced
vasodilation in rabbit excised aorta and in anesthetized whole animal., Biol.Pharm.Bull., 36:556-563, 2013.

8100B007(T.Oiszmi), I.Laakso, A.Hirata, O.Fujiwara, S.Watanabe, M.Taki, M.Kojima, H.Sasaki, K.Sasaki: FDTD analysis oftemperature elevation in the lens of human and rabbit models due to near-field and far-field exposures at 2.45
GHz., Radiat Prot Dosimetry, 155:284-291, 2013.

8100B008

Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, Y.Yamada: Elevated serum gamma-glutamyltransferase (GGT)
activity and the development of chronic kidney disease (CKD) in cigarette smokers., Nephrourol Mon, 5:967-973,
2013.

8100B009

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: The effects of continuing anddiscontinuing smoking on the development of chronic kidney disease (CKD) in the healthy middle-aged working
population in Japan., Environ. Health Prevent. Med., 18:24-32, 2013.

8100B010

Y.Noborisaka, M.Ishizaki, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Distribution of and factors
contributing to chronic kidney disease in a middle-aged working population., Environ. Health Prevent. Med., 18：466-476, 2013.

8100B011

M.Ishizaki, N.Kawakami, R.Honda, Y.Yamada, H.Nakagawa, Y.Morikawa, The Work Stress and Health Cohort
Study Group: A prospective study of psychosocial work characteristics and long sick leave of Japanese male
employees in multiple workplaces., Ind. Health, 51:398-405, 2013.

8100B012(GM.Singh), G.Danaei, F.Farzadfar, GA.Stevens, M.Woodward, D.Wormser, S.Kaptoge, G.Whitlock, Q.Qiao,
S.Lewington, E.Di Angelantonio, S.Vander Hoorn, CM.Lawes, MK.Ali, D.Mozaffarian, M.Ezzati, M.Sakurai,
H.Nakagawa, K.Nakamura, Y.Morikawa, Global Burden of Metabolic Risk Factors of Chronic Diseases
Collaborating Group: Diabetes Epidemiology: Collaborative analysis of Diagnostic criteria in Europe (DECODE);
Emerging Risk Factor Collaboration (ERFC); Prospective Studies Collaboration (PSC). The age-specificquantitative effects of metabolic risk factors on cardiovascular diseases and diabetes: a pooled analysis., PLoS
ONE, 8:e65174;1-10, 2013.

8100B013(W.Ruangyuttikarn), A.Panyamoon, K.Nambunmee, R.Honda, W.Swaddiwudhipong, M.Nishijo: Use of the kidney
injury molecule-1 as a biomarker for early detection of renal tubular dysfunction in a population chronically
exposed to cadmium in the environment., Springerplus, 2:533;1-8, 2013.

8100B014

PT.Tai, M.Nishijo, N.Thi Nguyet Anh, S.Maruzeni, H.Nakagawa, H.Van Luong, T.Hai Anh, R.Honda, T.Kido,
H.Nishijo: Dioxin exposure in breast milk and infant neurodevelopment in Vietnam., Occup. Environ. Med.,
70:656-662, 2013.

8100B015(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV.Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., Organohalogen Compounds., 75:1321-1324, 2013.

8100B016(T.Koyama), S.Yamamoto, K.Yoshida, Y.Arai, M.Sakurai, K.Nakamura, M.Nishijyo, Y.Nakanishi, S.Nagasawa,
Y.Morikawa, M.Tabata, H.Nakagawa: Calcium intake and associated other dietary factors in healthy enderly
people., Hokuriku Japanese Journal of Public Health., 40:6-13, 2013 (in Japanese) .

8100B017

M.Nakashima, Y.Morikawa, Y.Hamazaki, S.Sakurai, J.Kitagawa, M.Sakurai, H.Nakagawa: Total smoking ban on an
university campus and acquisition of smoking habits., Jpn J School Health, 55:396-401, 2013 (in Japanese) .

－ 132 －

Presentations at Conference
International Conference (Presentations)
8100I001

Y.Yamada, Y.Noborisaka, M.Ishizaki, R.Honda, H.Yokoyama, M.Tabata, M.Miyao: Risk factors related to thedevelopment of chronic kidney disease (CKD) in middle-aged workers, 6th ICOH International Conference on
Work Environment and Cardiovascular Disease, (Tokyo, '13.03)，6th ICOH International Conference on Work
Environment and Cardiovascular Disease. Abstract Book, p41, 2013.

8100I002

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, M.Nakashima, H.Nakagawa: Relationship between houseboundstatus and onset of need for ling term care among the elderly in arural town, The 5th international conference oncommunity health nursing research, (Edinburgh UK, '13.03).

8100I003

K.Iwai, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: Oppsite directional regulations of microRNA
expression in arterial smooth muscle cell by HMGA1 and CTCF on the scaffold/matrix-attachment regions, The
77th Annual Scientific Meeting of the Japanese Circulation Society, (Yokohama, '13.03)，Circulation Journal,
77(Suppl. I)：I-1648, 2013.

8100I004

M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki: Difference in ocular damage by 40 and 95 GHz exposure to rabbit eye,
The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

8100I005(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, K.Sasaki, H.Sasaki: Factors influencing visual function in eyes withretrodots by difference in size, The Association for Research in Vision and Ophthalmology, (Seattle, '13.05).

8100I006(PT.Tai), M.Nishijo, NTN.Anh, S.Maruzeni, H.Nakagawa, HV. Luong, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LKSon., Y.Morikawa, T.Kido, H.Nishijo: Perinatal dioxin exposure and neurodevelopment of children aged 3 years– A follow up study in Vietnam., The 33rd international Symposium on Halogenated Persistent Organic pollutants Dioxin 2013, (Daegue, Korea, '13.08).

8100I007(J.Chakarothai), Y.Suzuki, M.Taki, K.Wake, Kensuke Sasaki, S.Watanabe, M.Kojima: Analysis of millimeter-wave
exposure on rabbit eye using a hybrid PMCHWT-MoM-FDTD method, 2013 International Symposium on Antennas
and Propagation, (China, '13.10).

8100I008

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy of Electromagnetic Fields,(Washington, '13.11).

8100I009

M.Kojima: MMW ocular exposure, Global Coordination of Research and Health Policy on RF Electromagnetic
Fields, (Washingto, '13.11).

8100I010

K.Iwai, T.Morita, O.Iritani, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF and HMGA1 opposite directionallyregulate the gene expression of microRNAs at scaffold/matrix-attachment regions in the arterial smooth muscle
cell, American Heart Association Scientific sessions 2013, (Dallas, '13.11).

8100I011

M.Kojima, T.Okuno, D.Sliney: Animal studies of infrared cataract review of anial studies and discussions wolbarsht
and pitts studies (photochemical?) review of gldman and vogt experiments, The 2013 Baltimore optical Radiation
Workshop, (Baltimore, '13.12).

8100I012

H.Sasaki, M.Kojima, K.Sasaki: Epidemiological studies of caract with latitude -evdence for a thermal factor-, The
2013 Baltimore optical Radiation Workshop, (Baltimore, '13.12).

8100I013

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Rice consumption and incident risk for type 2 diabetes in Japanese men andwomen., 73rd Scientific Sessions, American Diabetes Association, (Chicago, IL, USA, '13).

－ 133 －

Liberal Arts

8510

Life Science (Natural Science)

Faculty
Title

Name

Field of Specialization

Professor

TANAKA Ichiro

Scientific sociology, History of technology

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Associate Professor

HASHIMOTO
Mitsumasa

Radiation Biology, Cell Biology

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Assistant Professor

OKUDA Koichi

Fixed-quantity rating system in the heart nuclear medicine

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)
Nuclear medicine, Nuclear cardiology, Imaging, Image processing, SPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing
Radiation, DNA double strand breaks (DSBs)
history of science, history of technology, Galileo Galilei, Isaac Newton, Venetian patent law
planaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell, lectin, galectin, β-galactoside, Xenopus, development, placenta, trophoblast

Outline of Research
Hashimoto:Function of DNA repair enzymes, especially protection mechanisms against DNA double strand breaks induced
ionizing radiation
Okuda:The aim of our research is to develop a computer algorithm for thequantitative assessment of myocardial perfusion and sympathetic nerve
activity in the nuclear cardiology.
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies haveindicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to abetter treatment for cancer.
The research theme is the history of early modern science and technology. The topics being studied include Galileo Galilei
and Venetian Patent Law enacted in 15th century.
１）Functional analysis of Galectins, a family of ・-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
２）Electron microscopic analysis of the mechanisms of regeneration of planarians.

－ 134 －

Publications
Originals
8510B001

Y.-S. Jiang, M.Maeda, M.Okamoto, M.Fujii, R.Fukutomi, M.Hori, M.Tatsuka, T.Ota: Centrosomal localization of
RhoGDIβ and its relevance to mitotic processes in cancer cells., Int. J. Oncol., 42:460-468, 2013.

8510B002

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Depletion of RNAbinding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells., Exp. Biol. Med.
(Maywood), 238:889-897, 2013.

8510B003(A.Kurosawa), S.Saito, S.So, M.Hashimoto, K.Iwabuchi, H.Watabe, N.Adachi: DNA ligase IV and artemis act
cooperatively to suppress homologous recombination in human cells: Implications for DNA double-strand breakrepair., PLoS ONE, 8:e72253;1-11, 2013.

8510B004(T.Hattori), T.Arikawa, Y.Fujioka, J.Maruyama, Y.Nakayama, Y.Ohba, T.Niki, T.Miyazaki, M.Hirashima, H.Kida:
Inhivition of influenza A virus infection by galectin-9., Jpn. J. Vet. Res., 61:5-18, 2013.

Presentations at Conference
International Conference (Presentations)
8510I001(K. Nakajima), K.Okuda, K. Nystrom, J. Richter, S. Matsuo, S. Kinuya, L. Edenbrandt: Application of a new left
ventricular edge-detection algorithm to small hearts: Effects of correction in Japanese patients., 11th
International Conference of Nuclear Cardiology, (Amsterdam, '13.05).

8510I002(S. Matsuo), K. Nakajima, K. Okuda, H. Wakabayashi, J. Taki, M.Tobisaka, S. Kinuya, M. Yamagishi: Evaluation of
Myocardial Perfusion,Metabolism and Sympathetic may offer further Risk Stratification in the Management ofPatients with Takotsubo Cardiomyopathy., 11th International Conference of Nuclear Cardiology, (Amsterdam,'13.05).

8510I003(K. Nakajima), K.Okuda, Y. Kirihara, T. Hosoya, S. Matsuo, S. Kinuya: Standardization of I-123 meta-iodo benzyl
guanidine heart-to-mediastinum ratio in 33 hospitals and 101 camera-collimator combinations in Japan., Annual
Congress of the European Association of Nuclear Medicine., (Lyon, '13.10).

－ 135 －

8530

Life Science(Physical Education)

Title

Name

Field of Specialization

Senior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Faculty

Keywords of Research
exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE class

Outline of Research
Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons.
In addition, our research focuses on improvement of physical fitness through soccer in PE classes for children.

－ 136 －

8550

Human Science(Humanities)

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKEDA Koichi

Philosophy, History of logic

Senior Assistant Professor

HONDA Kojiro

Ethics of technology

Keywords of Research
logic, metaphysics, form, content, predicate, category, deduction, induction, matter, being, substance, definion,
Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics,
Cognitive Science of Learning, History of Science, Philosophy of Science, Science Policy Studies

Outline of Research
TAKEDA:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.
HONDA:It is inquiring about the ethics of technology.
"Tradition of knowledge" has considered the problem what kind of responsibility occurs why in possible one and the sidewhich inherits knowledge again, by the mainly phenomenological technique.

Presentations at Conference
International Conference (Presentations)
8550I001

K.Honda: Japanese engineering ethics and roboethics, SPT2013, (Lisbon, '13.07).

8550I002

K.Honda: Academic liberth and academic regulation : Fukushima disaster inboking the old and new problem,
SPT2013, (Lisbon, '13.07).

8550I003

K.Honda: Chair of Panel A “Social Implementation of Robotics in Japan and Its Ethical Implication, SPT2013,(Lisbon, '13.08).

－ 137 －

8570

Human Science(Mathematics)

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Senior Assistant Professor

INOUE Tomoki

Graph theory in toplogy

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, graph theory in topology, topological polyhedron

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Inoue:We extend the Graph Theory, and define a topologicalpolyhedron which coverd on closed surface of genus g. We give
characterizations and example of the topological polyhedron.

－ 138 －

8590

Human Science (Foreign Languages)

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

IKENAKA Masami

English Education

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical English, elearning
end of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the
English found in medical articles to determine the most commonly used
words, forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.

－ 139 －

Publications
Reviews
8590C001

K.Kakizaki: Mystery of love in the actual., Mem. Lib. Kanazawa Med. Univ., 41:1-13, 2013.

－ 140 －

Affiliated Institution

9030

Northerm Noto Institute for Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Assistant
Professor(Additional Post)

KITAMURA Kenji

Hip surgery

Keywords of Research
The Elderly, Rural Medicine, Medical Needs

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

Publications
Originals
9030B001(Y.Imai), S.Morimoto, T.Nakahashi, GEANE study group & HOMED-BP study group: Genome-wide response to
antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP
study., Pharmacogenomics, 14:1709-1721, 2013.

－ 141 －

9050

FDD-MB Center

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's
health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology

Publications
Originals
9050B001(K.Yamanaka), M.Saito, M.Kita, Y.Takamura, G.Hashiguchi, H.Takabayashi, E.Tamiya: A single cell genedetection using micro-tweezers and the microchamber polymerase chain reaction for the fetal DNA analysis., Sens.
Actuators. B. Chem., 178:678-682, 2013.

9050B002(R.Ozaki), H.Oda, R.Usuda, Y.kumazawa, N.Kato, M.Kita, H.Takabayashi: Automatic Detection of Nucleated Red
Blood Cells from Microscope Images using Cell-Hog Feature, Journal of the Japan Society of Precision
Engineering., 79:1074-1077, 2013 (in Japanese) .

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Himi Municipal Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery

Professor

FUKUDA Akihiro

Cardiology

Professor

IZUMI Youichi

Hypertension, Endocrinology

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

MORIYAMA Manabu

Kidney transplantation，Urolithiasis

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Professor

MATSUKI Nobuo

Oncology Surgery

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

KUZAWA Yutaka

Cardio Vascular Surgery

Associate Professor

IKEBUCHI Kimihiro

Orthopaedic Surgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Associate Professor

URASHIMA Sachio

Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.

Senior Assistant Professor

ASANO Masamitsu

Cardiology

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

KIYOSAWA Jun

Cardiology

Senior Assistant Professor

AOKI Nobuyuki

Orthopaedic Surgery

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies

Assistant Professor

MIZUNO Takuro

Cardiology

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

ARISAWA Akiko

Orthopaedic Surgery

Assistant Professor

KUSABA Eizo

neurosurgery

Assistant Professor

MURANAKA Emiri

Regional medicine

Assistant Professor

SAKAMOTO Daisuke Cardiovascular Surgery

Assistant Professor

OKAMURA Hideyuki

Assistant Professor

SHIMADA Toshitsugu Dermatology

Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer－ 143 －

Publications
Originals
9100B001

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantage of diffusion-weighted imaging over positron emission tomography-computed in assessment ofhilar and mediastinal lymph node in lung cancer., Ann. Surg. Oncol., 20:1676-1683, 2013.

9100B002

Y.Fujimoto, J.Huang, T.Fukunaga, R.Kato, M.Higashino, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya,
M.Saito, M.Kobayashi, K.Kojima, T.Oikawa, K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, S.Mizuno,
K.Osanai, H.Toga: A three-microphone acoustic reflection technique using transmitted acoustic waves in the
airway, J. Appl. Physiol., 115:1119-1125, 2013.

9100B003

T.Kanda, R.Chen, T.Mizuno, D.Sakamoto, D.Usuda, M.Mori, M.Takahashi, N.Kato, H.Sumino: Cardiac
BDNF/TrkB signaling can be induced by calorie restriction with improved physical activity in obese mice., The
Internet Journal of Cardiovascular Research., 8, 2013.

Case Reports
9100D001

T.Kanda, T.Mizuno, M.Ishigaki, K.Nakajima, T.Matsue, M.Fukushima, H.Minato, N.Nojima, S.Atsushi, K.Ishigami,
H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, A.Fukuda, Y.Izumi, N.Takekoshi:
Spontaneous remission of epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly., Case Rep
Oncol., 6:269-274, 2013.

9100D002

I.Chikazawa, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, T.Uchibayashi: Two cases of ureterocele withureteral stone., Japanese Journal of Urological Surgery, 26:1015-1019, 2013 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
9100I001(K.Ohta), T.Fujiki, M.Yamamiya, N.Inoue, Y.Senda, S.Sakazume, K.Ueno, T.Yokoyama, M.Shimizu, A.Yachie:
Normal Values for Pediatric Urinary Biochemistry, The 16th congress of the International Pediatric Nephrology
Association, (Shanghai, '13.08).

9100I002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Kuginuki, M.Taniguti, Y.Ueda,
T.Sakuma: Advantages of diffusion-weighted imaging over positron emission tomography-computed tomography inassessment of hilar and mediastinal lymph node in lung cancer, 18th world cangress on advances in oncology,(Athens, '13.10).

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Research Activities and Publications
VOL. 25 2013

Kanazawa Medical University