107 | 1 | 18

Neuroendocrinology
107(1) 1–104 (2018)

Promote reward PVN
related feeding Oxytocin

NAc

print
ISSN 0028–3835

VTA

SON

NPY/
Oxytocin POMC AgRP
KATP channel

ARC

GlucoseS. Karger
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Official Journal ofInternational Neuroendocrine Federation
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European Neuroendocrine Tumor Society

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New evidence-based insights and developments

Vitamin D in
Clinical Medicine
Editors

Andrea Giustina
John P. Bilezikian

Vitamin D in Clinical Medicine
Editors: Giustina, A. (Milan); Bilezikian, J.P.
(New York, NY)
VIII + 206 p., 10 fig., 4 in color, 14 tab., 2018
CHF 160.00 / EUR 150.00 / USD 188.00
Hard cover or online prices for personal customers
Prices subject to change, VAT not included
EUR price for eurozone countries,
USD price for USA and Latin America onlyISBN 978–3–318–06338–7
e-ISBN 978–3–318–06339–4
Frontiers of Hormone Research, Vol. 50
Series Editor: Ghigo, E.; Guaraldi, F. (Turin)
ISSN 03013073 / e-ISSN 16623762
Listed in MEDLINE/PubMed

Vitamin D deficiency is prevalent today not only
among the elderly but pervasively throughout allages of life. This is due, in part, to systemic diseases
that affect vitamin D metabolism, to changes in lifestyle, such as insufficient exposure to sunlight, andto increased use of sunscreen. Apart from the obvious effects of vitamin D deficiency on skeletal metabolism, the problem is assuming even greater significance because observational and interventional
studies have linked vitamin D deficiency to cardiovascular disease, cancer, and diabetes.
This book addresses a variety of important issues thathave emerged from this fast-moving area of clinicalmedicine. The topics include assays of vitamin D and
its binding protein, effects on aging and associatedcomplications, primary and secondary states of altered parathyroid hormone secretion, vitamin D in
the growing years of children and adolescents, nutritional requirements, and vitamin D as it relates tosystemic disorders such as diabetes mellitus.
Vitamin D in Clinical Medicine aims to offer new insights, in an evidence-based way, on important issues related to vitamin D. It is written for generalpractitioners and internists, as well as for endocrinologists, nutritionists, pulmonologists, cardiologists,and oncologists.

Contents• Preface: Giustina, A.; Bilezikian, J.P.
• Physiology of the Calcium-Parathyroid

Hormone-Vitamin D Axis: Goltzman, D.;
Mannstadt, M.; Marcocci, C.

• Vitamin D Assays: Bikle, D.D.
• Vitamin D-Binding Protein: Vilaça, T.;

Lazaretti-Castro, M.

• New Concepts in Vitamin D Requirements forChildren and Adolescents: A Controversy Revisited:
Laing, E.M.; Lewis, R.D.

• Practical Issues in Vitamin D Replacement:

Adler, R.A.

• Extra-Skeletal Effects of Vitamin D: Bouillon, R.
• Hypercalcemic States Associated with

Abnormalities of Vitamin D Metabolism: Jones, G.;

Schlingmann, K.-P.

• Vitamin D and Hypoparathyroidism: Bandeira, L.C.;

Rubin, M.R.; Cusano, N.E.; Bilezikian, J.P.

• Vitamin D and Primary Hyperparathyroidism:

Walker, M.D.; Bollerslev, J.

• Vitamin D and Secondary Hyperparathyroid States:

Cipriani, C.; Pepe, J.; Colangelo, L.; Minisola, S.

• Vitamin D and Glucocorticoid-Induced

Osteoporosis: Mazziotti, G.; Formenti, A.M.; Frara, S.;
Doga, M.; Giustina, A.
• Vitamin D and Diabetes Mellitus: Maddaloni, E.;
Cavallari, I.; Napoli, N.; Conte, C.
• Vitamin D, Sarcopenia and Aging: Skaaby, T.;
Thuesen, B.H.; Linneberg, A.
• Vitamin D Homeostasis and Diseases in Pediatrics:

Dear Librarian

Bianchi, M.L.

I have reviewed this publication andwould like to recommend it for our library.

Author Index/Subject Index

Recommended by:

Department:

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KI18128

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Official Journal ofInternational
Neuroendocrine
Federation (INF)
European
Neuroendocrine
Association (ENEA)
European
Neuroendocrine
Tumor Society (ENETS)

International Journal for Basic and Clinical Studies on
Neuroendocrine Relationships
Founded 1965 by E. Bajusz
Continued by K.M. Knigge (1973–1978); W.F. Ganong (1979–1984);
S.M. McCann (1985–1993); C. Kordon (1994–2005)

Editor-in-Chief

Editorial Board

R.P. Millar, Gorebridge/Pretoria

D.H. Abbott, Madison, Wis.
E. Arzt, Buenos Aires
A.V. Babwah, London, Ont.
S. Boikos, Richmond, Va.
B. Canny, Monash, Vic.
M. Caplin, London
A. Chodobski, Providence, R.I.
P.J. Enriori, Monash, Vic.
K.L. Grove, Beaverton, Oreg.
A.E. Herbison, Dunedin
J. Herman, Cincinnati, Ohio
J.J. Hirst, Callaghan, N.S.W.
U. Kaiser, Boston, Mass.
G. Kaltsas, Athens
K. Kim, Seoul
A.C. Latronico, São Paulo
G. Leng, Edinburgh
J.E. Levine, Evanston, Ill.
C. Libertun, Buenos Aires
C. Llorens-Cortes, Paris
A. Lomniczi, Beaverton, Oreg.
A. Loudon, Manchester
M. Ludwig, Edinburgh
G. Martinez de la Escalera, Querétaro
R.C. Melcangi, Milan

Editorial Manager
A. Kirsop, Gorebridge
Editors
C. Coen, London
M.A. Cowley, Clayton, Vic.
W.W. de Herder, Rotterdam
S.L. Dickson, Gothenburg
A.B. Grossman, Headington
D. Jezová, Bratislava
A.S. Kauffman, La Jolla, Calif.
M.J. Kelly, Portland, Oreg.
A.S. Laganà, Varese
J.J. Mukherjee, Kolkata
S.J.C.M.M. Neggers, Rotterdam
X. Ni, Shanghai
D. O’Toole, Dublin
V. Prévot, Lille (Reviews)
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H. Sasano, Sendai
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E. Terasawa, Madison, Wisc.
H. Tsukamura, Nagoya
E.J. Wagner, Pomona, Calif.
B. Wiedenmann, Berlin
Z. Zeng, Beijing

I. Modlin, New Haven, Conn.
Z. Naor, Tel Aviv
V.M. Navarro, Boston, Mass.
C. Newton, Pretoria
M. Palkovits, Budapest
I.S. Parhar, Kuala Lumpur
D.W. Pfaff, New York, N.Y.
T.M. Plant, Pittsburgh, Pa.
J. Raimondo, Cape Town
J.M.H.M. Reul, Bristol
R. Reynolds, Edinburgh
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P. Ruszniewski, Clichy
D.C. Skinner, Laramie, Wyo.
M. Sleeman, Clayton, Vic.
J. Smith, Perth, W.A.
G.H. Son, Seoul
F. Spiga, Bristol
E. Spinedi, La Plata
R.A. Steiner, Seattle, Wash.
M. Watt, Melbourne, Vic.
K. Weston-Green, Wollongong, N.S.W.
M.E. Wierman, Aurora, Colo.
S. Wray, Bethesda, Md.
J. Young, Le Kremlin-Bicêtre

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Journal Information

Guidelines for Authors
We strongly encourage authors to readthe Guidelines for Authors at
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submitting an article.

Aims and Scope
Neuroendocrinology publishes papers reporting original research in basic and clinical neuroendocrinology. The journal explores the complex interactions between neuronal networks
and endocrine glands (in some instances also immune cells) in both central and peripheral
nervous systems. Original contributions cover all aspects of the field, from genetic, molecular and cellular neuroendocrinology, physiology, pharmacology, and the neuroanatomy ofneuroendocrine systems to neuroendocrine correlates of behaviour, clinical neuroendocrinology and neuroendocrine cancers. Neuroendocrinology is the official journal of the European Neuroendocrine Tumor Society (ENETS) and includes updates on ENETS guidelines.
Readers will also benefit from reviews by noted experts, which highlight especially active
areas of current research, and special focus editions of topical interest.

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ESPE 2018
57th Annual
ESPE Meeting
27-29 September
Athens, Greece

Narrative and Precision Medicine
in Paediatric Endocrinology
ABSTRACT SUBMISSION DEADLINE:

16 April 2018
EARLY BIRD DEADLINE:

www.espe2018.org

F1814122 June 2018

2018
Bridging the World of Endocrinology

25-28 October 2018w w w . e n d o b r i d g e . o r g

F18232

Regnum Carya Hotel
Antalya - Turkey

Your key source for managing the transition periodwith case histories and learning points

Transition of Care

Endocrine Development
Editor: P.-E. Mullis
Vol. 33

From Childhood to Adulthood in Endocrinology,
Gynecology, and Diabetes

Transition of Care
From Childhood to Adulthood in
Endocrinology, Gynecology, and Diabetes
orrs
EditorsP
M. PolakouraineTouraine
P. To

Editors

Michel PolakPhilippe Touraine

Transition of Care
From Childhood to Adulthood in Endocrinology,
Gynecology, and Diabetes
Editors. Polak, M.; Touraine, P. (Paris)
VIII + 162 p., 14 fig., 3 in color, 11 tab., 2018
CHF 138.00 / EUR 129.00 / USD 162.00
Hard cover or online prices for personalcustomers
Prices subject to change, VAT not included
EUR price for eurozone countries,
USD price for USA and Latin America onlyISBN 978–3–318–06142–0
e-ISBN 978–3–318–06143–7
Endocrine Development, Vol. 33
ISSN 1421–7082 / e-ISSN 1662–2979
Listed in PubMed/MEDLINE, Scopus,
Google Scholar, WorldCat

Pediatricians face many questions and challenges
during patients’ transition from childhood to adulthood. Chronic diseases justify long-term medical,
psychological, educational, and social management.
The establishment of networks with adult endocrinologists is, therefore, very important to achieving
optimal conditions for a successful transition period.

Specific Illnesses• Transition of Care from Childhood to Adulthood:
Congenital Adrenal Hyperplasia: Bachelot, A.
• Transition of Care from Childhood to Adulthood:
Turner Syndrome: Conway G.
• Growth Hormone Deficiency in the Transition Age:In this book, leading experts discuss major publichealth issues such as diabetes and obesity. They also
review genetic diseases, including Turner syndromeand congenital adrenal hyperplasia. All clinical cases
are presented in a focused way to highlight any issues which might be discussed by the doctor withpatients and family. Psychological approaches aredebated as are proposals for defining specific tools
to encourage autonomy during this life period.
This book is a valuable tool and will be helpful in answering many questions for endocrinologists, adultand pediatric, dedicated to the long-term management of patients with chronic diseases.

• Management of Hypothalamic Obesity during
Transition from Childhood to Adulthood:Contents
Preface : Touraine, P. ; Polak, M.
General Concepts• Challenges of the Transition from Pediatric Careto Care of Adults: “Say Goodbye, Say Hello”:
Dear Librarian

Touraine, P.; Polak, M.

I have reviewed this publication andwould like to recommend it for our library.

• “Child-Adult” Transition – Adolescence: When
Illness Appears…: Malivoir, S.; Gueniche, K.

Recommended by:Loche, S.; Di Iorgi, N.; Patti, G.; Noli, S.; Giaccardi, M.;
Olivieri, I.; Ibba, A.; Maghnie, M.

Bretault, M.; Carette, C.; Barsamian C.; Czernichow, S.

• Transitions in Care from Pediatric to Adult HealthCare Providers: Ongoing Challenges andOpportunities for Young Persons with Diabetes:
Garvey, K.; Laffel, L.

• Transition of Care from Childhood to Adulthood:
Congenital Hypogonadotropic Hypogonadism;
Dwyer, A.A.; Pitteloud, N.

• The Transition from Paediatric to Adult Care for
Youths with Thyroid Diseases: Outcome Issues andChallenges: Léger, J.
• Transition in Pediatric and Adolescent
Hypogonadal Girls: Gynecological Aspects,
Estrogen Replacement Therapy, andContraception: Pedersen, A.T.; Cleemann, L.;
Main, K.M.; Juul, A.

• Fertility Preservation in Endocrine Disorders
during Transition for Girls: Bénard, J.; Sermondade, N.;
Grynberg, M.

• Fertility Preservation in Klinefelter Syndrome
Patients during the Transition Period: Rives, N.;

Rives, A.; Rondanino, C.; Castanet, M.; Cuny, A.; Sibert, L.

Author Index / Subject Index

Department:

Signature:

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KI18172

Date:

Participate in this rapidly developing field of research

Editor-in-Chief

W. Savino,
Rio de Janeiro
Associate Editor

A. del Rey, Marburg

Official Organ of theInternational Society for
Neuroimmunomodulation

The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the
immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, Neuroimmunomodulation reports on all aspects of these interactions. Basic investigations consider
all neural and humoral networks from molecular genetics through cell
regulation to integrative systems of the body. The journal also aims toclarify the basic mechanisms involved in the pathogenesis of the CNS
pathology in AIDS patients and in various neurodegenerative diseases.
Although primarily devoted to research articles, timely reviews are published on a regular basis.

Selected contributions• Stress, the Stress System and the Role of Glucocorticoids: Nicolaides, N.C.;
Kyratzi, E.; Lamprokostopoulou, A. (Athens); Chrousos, G.P. (Athens/Jeddah);Charmandari, E. (Athens)• Calcitonin Gene-Related Peptide Modulates the Production of
Pro-Inflammatory Cytokines Associated with Periprosthetic Osteolysis by
THP-1 Macrophage-Like Cells: Jablonski, H.; Kauther, M.D.; Bachmann, H.S.;
Jäger, M.; Wedemeyer, C. (Essen)• The Association of Openness Personality Trait with Stress-Related Salivary
Biomarkers in Burning Mouth Syndrome: de Souza, F.T.A.; Kummer, A.;
Silva, M.L.V.; Amaral, T.M.P.; Abdo, E.N.; Abreu, M.H.N.G.; Silva, T.A.; Teixeira,
A.L. (Belo Horizonte)• A Follow-Up Study of 50 Chronic Hepatitis C Patients: Adiponectin as a
Resilience Biomarker for Major Depression: Fábregas, B.C.; Vieira, É.L.M.;
Moura, A.S.; Carmo, R.A.; Ávila, R.E.; Abreu, M.N.S. (Belo Horizonte);
Prossin, A.R. (Houston, TX); Teixeira, A.L. (Belo Horizonte)

Listed in bibliographic services, including:
PubMed/MEDLINE, Web of Science,
Google Scholar, Scopus, Embase
2018: Volume 25
6 issues per volume
Language: English
ISSN 1021–7401
e-ISSN 1423–0216
Impact Factor: 2.674

von Känel, R. (Bern/ Barmelweid); Keresztes, M. (Szeged)• The Possible Role of Toll-Like Receptor 4 in the Pathology of Stroke:
Hakimizadeh, E.; Kazemi Arababadi, M.; Shamsizadeh, A. (Rafsanjan);
Roohbakhsh, A. (Mashhad); Allahtavakoli, M. (Rafsanjan)• Activated Phosphorylated STAT1 Levels as a Biologically Relevant
Immune Signal in Schizophrenia: Sharma, R.P.; Rosen, C.; Melbourne, J.K.;
Feiner, B. (Chicago, IL); Chase, K.A. (Chicago, IL/La Jolla, CA)• Cytokine and Chemokine Profiles in Patients with Neuromyelitis Optica
Spectrum Disorder: Wang, Y.; Zhou, Y.; Sun, X.; Lu, T.; Wei, L.; Fang, L.; Chen, C.
(Guangzhou); Huang, Q. (Guangzhou/Zhaoqing); Hu, X.; Lu, Z.; Peng, L.; Qiu, W.
(Guangzhou)

More information at w w w. karger.com/nim

KF18079

Neuroimmunomodulation
Founded: 1994
Category: Basic Research
Fields of Interest: Neurology, Endocrinology, Immunology• The Monocyte-to-Lymphocyte Ratio Correlates with
Psycho-Neuro-Inflammatory Factors in Patients with Stable Coronary
Artery Disease: Serfőző, G.; Horváth, T.; Földesi, I.; Rafael, B. (Szeged);Compelling questions and future directions

Frontiers of Hormone Research
Editor: E. Ghigo
Vol. 49

Metabolic Syndrome
consequent to
Endocrine Disorders
Editors

V. Popovic
M. Korbonits

Metabolic Syndrome
Consequent to Endocrine
Disorders
Editors

Vera Popovic
Marta Korbonits

Metabolic Syndrome Consequent to
Endocrine Disorders
Editors: Popovic, V. (Belgrade); Korbonits, M.
(London)X + 174 p., 19 fig., 13 in color, 4 tab., 2018
CHF 148.00 / EUR 138.00 / USD 174.00
Hard cover or online prices for personal customers
Prices subject to change, VAT not included
EUR price for eurozone countries, USD price for USA
and Latin America onlyISBN 978–3–318–06334–9
e-ISBN 978–3–318–06335–6
Frontiers of Hormone Research, Vol. 49
Series Editor: Ghigo, E.; Guaraldi, F. (Turin)
ISSN 0301–3073 / e-ISSN 1662–3762
Listed in MEDLINE/PubMed
Fields of Interest: Endocrinology; Metabolism;
Diabetes, Obesity, Reproduction

Hormonal dysfunction can have a major and often complex impact
on all key components of the metabolic syndrome. This book comprises state-of-the-art reviews on the subject written by recognizedexperts in the field of endocrinology. Each chapter covers specificmanifestations associated with the metabolic syndrome in classic
endocrine diseases. Compelling questions are highlighted andfuture directions presented. The topics covered include hypopituitarism, adrenal insufficiency, acromegaly, glucocorticoid excess,androgen excess, hypogonadism, prolactin, and thyroid and parathyroid hormone abnormalities.
This book is meant to inspire subsequent research related to metabolic complications in endocrine diseases, thus enabling early
detection as well as prompt and appropriate management.
Contents• Preface: Popovic, V.; Korbonits, M.
• Metabolic Syndrome in Hypopituitarism: Miljic, D.; Popovic, V.
• Metabolic Complications of Acromegaly: Mercado, M.;

Ramírez-Rentería, C.

• Metabolic Syndrome in Hyperprolactinemia: Andersen, M.;

Glintborg, D.

• Metabolic Syndrome in Thyroid Disease: Iwen, K.A.; Oelkrug, R.;

Kalscheuer, H.; Brabant, G.

• Metabolic Syndrome in Parathyroid Diseases: Corbetta, S.;

Mantovani, G.; Spada, A.

• Metabolic Syndrome in Cushing’s Syndrome Patients: Ferraù, F.;

Korbonits, M.

• Metabolic Complications in Adrenal Insufficiency: Ueland, G.A.;
Dear Librarian
I have reviewed this publication andwould like to recommend it for our library.
Recommended by:

Husebye, E.S.

• Metabolic Syndrome in Polycystic Ovary Syndrome: Pasquali, R.
• Metabolic Syndrome in Male Hypogonadism: Rastrelli, G.;

Filippi, S.; Sforza, A.; Maggi, M.; Corona, G.

• The Metabolic Syndrome in Central Hypogonadotrophic

Hypogonadism: Dwyer, A.A.; Quinton, R.
Author Index / Subject Index
Department:

Signature:

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or through a Karger representative.

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ki18126

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www.karger.com/nen

107 | 1 | 18

Original Paper  1 Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-DifferentiatedIntestinal Neuroendocrine Tumors
Briest, F. (Berlin/Bad Berka); Grass, I.; Sedding, D.; Möbs, M.; Christen, F.; Benecke, J.; Fuchs, K.;
Mende, S. (Berlin); Kaemmerer, D.; Sänger, J.; Kunze, A. (Bad Berka); Geisler, C. (Potsdam);Freitag, H.; Lewens, F.; Worpenberg, L.; Iwaszkiewicz, S.; Siegmund, B.; Walther, W.; Hummel, M.
(Berlin); Grabowski, P. (Berlin/Bad Berka)
24 Clinical and Biomarker Evaluations of Sunitinib in Patients with Grade 3 Digestive

Neuroendocrine Neoplasms
Pellat, A.; Dreyer, C.; Couffignal, C. (Paris); Walter, T.; Lombard-Bohas, C. (Lyon); Niccoli, P.;
Seitz, J.F. (Marseille); Hentic, O. (Clichy); André, T.; Coriat, R.; Faivre, S. (Paris); Zappa, M.;
Ruszniewski, P.; Pote, N.; Couvelard, A. (Clichy); Raymond, E. (Paris)

32 Follow-Up for Resected Gastroenteropancreatic Neuroendocrine Tumours:

A Practice Survey of the Commonwealth Neuroendocrine Tumour Collaboration(CommNETS) and the North American Neuroendocrine Tumor Society (NANETS)
Chan, D.L.; Moody, L. (Toronto, ON/Sydney, NSW); Segelov, E. (Melbourne, VIC); Metz, D.C.
(Philadelphia, PA); Strosberg, J.R. (Tampa, FL); Pavlakis, N. (Sydney, NSW/St Leonards, NSW);Singh, S. (Toronto, ON)

42 Presenting Symptoms and Delay in Diagnosis of Gastrointestinal and Pancreatic

Neuroendocrine Tumours
Basuroy, R. (London); Bouvier, C. (Leamington Spa); Ramage, J.K. (London); Sissons, M.
(Leamington Spa); Kent, A.; Srirajaskanthan, R. (London)

50 Extra-Pulmonary Neuroendocrine Carcinomas: A Population-Based Study in the

Netherlands
van der Zwan, J.M. (Utrecht); Siesling, S. (Utrecht/Enschede); van Velthuysen, L. (Rotterdam);
Links, T.; Walenkamp, A. (Groningen); Tesselaar, M. (Amsterdam)

60 Influence of Sleep Stage on LH Pulse Initiation in the Normal Late Follicular Phaseand in Polycystic Ovary Syndrome
Lu, C.; Hutchens, E.G.; Farhy, L.S.; Bonner, H.G.; Suratt, P.M.; McCartney, C.R.
(Charlottesville, VA)
At the Cutting Edge

73 A Comprehensive Assessment of the Role of miRNAs as Biomarkers in

Gastroenteropancreatic Neuroendocrine Tumors
Malczewska, A. (Katowice); Kidd, M.; Matar, S. (Branford, CT); Kos-Kudla, B. (Katowice);
Modlin, I.M. (New Haven, CT)

91 The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

Maejima, Y.; Yokota, S. (Fukushima); Nishimori, K. (Sendai); Shimomura, K. (Fukushima)

Cover illustration
Proposed model for oxytocin-related neural pathways that regulate foodintake. The red arrows indicate the stimulatory projections and the blue
arrows indicate the inhibitory projections. For details see Maejima et al., p. 92.