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Laboratory and Epidemiology Communications

Surveillance of PolioviruS‑Isolates in Japan, 1 999
Tetsuo Yoneyama* , Yoshiaki Karojil , Kanako Watanabe2, Misako Tsuchiya3,
MamoruNakano4 and Tatsuo Miyamura
Department of ViylDlogy lI, National Institute ofInfectious Diseages,
MusashimunvJama 208‑0011,]Kyoto CiO7 Institute of Health and Environmental Sciences,
Kyoto 604‑8845,

2Niigata Pylefectural Resewch Labwatorvfor Health and Enviy10nment,
Niigata 950‑21 44,

3Fukushima Institute of Health and Enviy10nmental Sciences,
Fukushima 960̲81 63 and4Nara Prefectural Institute of Public Health,Nara 630‑8131
Commumicated by Tatsuo Miyamura(Accepted May 29, 2000)

In 1999, I 1 polioviruses were isolated from nine clinical

Asshown in Table 1, all of the examined polioviruses werevaccine‑derived strains. Type 3 poliovirus was isolated frompatientsinfour prefectures. Samples of the viruses were sent toNational Institute of Infectious Diseases (NIID)and subjectedto the intratypic differentiation by PCR‑restriction fragment
length polymorphism method developed by Radu Crainic ( 1 ).

the stool specimen of a poliomyelitis patient in Kyoto, andexamined forintratypic differentiationin1999. Sincethe onsetof the paralysISinthe Kyoto case occurredinNovember 1 998,

Table I. Characterization ofpoliovirus isolates in 1999

Date of vaccination

CodeAgeSex

inthe patient in the area.Dnas?.of sDaamb,監g Eili;ic.aslis Serotype

盗監禁監ti｡n99 ‑kyot0‑ I2Y

M

98‑ 1 0‑28(2nd)98‑ll‑1998‑ll‑19

Poliomyeliti s

Polio‑399 ‑kyot0‑27M

F

98‑4‑1 6

98‑5‑2

98‑5‑2

Aseptic meningiti s

Polio ̲2

ⅥlCCine̲li ke

99‑Niigata‑ 1IY

F

98‑10‑23

99‑4‑ 1 6

99‑4‑5994‑9

Gastroenteritis

Polio̲ 1 &2

Vacc ine‑likePolioーlVacc ine̲ like9 9 ‑Ni igata‑22YM

98‑ll‑2

99‑4‑5Unknown

99‑4‑1299 ̲Fukushima̲ 15YM

Unknown

98‑1 0̲30

99‑2‑1799‑2‑ 1 7

Erythema infectiosum*URD

99 ‑Fukushima‑27M

M

None

99‑4‑1 5994‑30

99‑4‑30

99 ‑Niigata‑ 33YF

97‑5‑9(2nd)

99‑5‑1499‑5‑3 1

99 ‑Ni igata‑47YF

Unknown

99‑4‑ 1 3

99‑6‑24

99‑Nara‑ 18M

F

None

99‑10‑26

99‑1ト24* : Upper respiratory disease* * : Idiopathicthrombocytopenic purptm*Corresponding author: Fax: +8 1 ‑42‑56 1 ‑4729, E‑mail:tyoneyam@nih.gojp90Vacc ine̲ like

Polio̲ 1ⅥlCCine̲like**ITP

Polio ̲2

Ⅵccine̲like

99‑5‑3 1URD

Polio‑ 1

Vaccine‑like

99‑6‑25

Herpanglna

Polio̲ 1

Vacc ine̲ like99‑1 1‑24Dia汀hea

Polio̲2&3

Vaccine̲likeJpn. J. Infect. Dis., 53, 2000
Table 2. Annual incidence of typical poliomyelitis (1970‑ I 999)

No. of cases
Year Total

No. of cases with indicated serotypes

空禦!聖lf^ol j̲?.I:i.?̲vi̲T^S̲A 1 2

3 1,32,3 1,2,3

virus isolation positive cases
1970

551971221972221973661974331975111976

11197721978
1979

111441981

441982001983221984011198611198700198800198900199000199111199222199333199411199500

1001997

001998229990LLILILIl ( l一 E I I i I l 一l‑一L L 一 1 一I I E 一一

1 1 L l 一一一 l 一 1*

辛‑ 一一一一一一一一一

Ell 一 lI1LIL

一一一一一 l 一 LLl 1 1 一 12 1 一一一一一一一一

1 I 一1 一 ‑ 一一一一01985

12 1 1 4 2 一 2 一I

211980996

LLII 一 rlLIL一一一一一l I L L ‑ I I r ,,1 l

I l 一2 1 1 r J L a

一一2 1 一一一一 ‑ 一L E 一一 L 一一一 l 一r I‑ L I L ‑ l I 1 II I

一一一一一一一0+: Non̲vaccinellike

the total number of incidences of poliomyelitis in 1 998 was

was isolated from AFP patients examined in 1999. Thetwo, including the case in Hokkaido (2). Poliomyelitis cases

importance of strengthening polioviruS surveillance untilin Japan from 1970 to 1999 are summarized in Table 2 forglobal eradication of poliomyelitis should be emphasized･reference.

In the Kyoto case, paralysis developed after the second
admimistration of oral poliovirus vaccine (OPV). Pohomyelitis
after 2 doses of OPV has been never reported in these 30

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