Kanazawa Medical University
Research Activities and Publications
VOL.292017

Kanazawa Medical University

INDEX
Code

Depaertment

Page

Code

Basic Medical Science

Depaertment

Page

0475

Department of Otorhinolaryngology

・・・・・・・・

75

0100

Department of Anatomy Ⅰ・・・・・・・・

1

0485

Department of Head and Neck Surgery

・・・・・・・・

77

0110

Department of Anatomy Ⅱ・・・・・・・・

20490

Department of Dermatology

・・・・・・・・

79

0120

Department of Physiology Ⅰ・・・・・・・・

30500

Department of Urology

・・・・・・・・

81

0130

Department of Physiology Ⅱ・・・・・・・・

40510

Department of Obstetrics and Gynecology

・・・・・・・・

82

0140

Department of Biochemistry Ⅰ・・・・・・・・

60520

Department of Anesthesiology and0150

Department of Biochemistry Ⅱ・・・・・・・・

7

・・・・・・・・

84

0160

Department of Pharmacology

・・・・・・・・

80170

Department of Pathology Ⅰ・・・・・・・・

9

Medicine・・・・・・・・

86

0180

Department of Pathology Ⅱ・・・・・・・・

11

Department of Emergency Medicine

・・・・・・・・

87
88

Perioperative Medicine
0540

0550

Department of Physical and Rehabilitation

0190

Department of Microbiology

・・・・・・・・

120570

Department of Community Medicine

・・・・・・・・

0200

Department of Immunology

・・・・・・・・

130575

Department of Gastroenterological Endoscopy

・・・・・・・・

90

0210

Department of Medical Zoology

・・・・・・・・

140577

Department of Cardiovascular Intervention

・・・・・・・・

92

0220

Department of Pathology and Laboratory

0580

Department of Oral and Maxillofacial Surgery

・・・・・・・・

93

・・・・・・・・

150590

Department of Regenerative Medicine

・・・・・・・・

95

Medicine・・・・・・・・

17

Department of Epidemiology and Public Heaｌｔｈ・・・・・・・・

19

8010

Fundamental Nursing

・・・・・・・・

96

edicine0230

0240

Department of Social and Environmental

School of Nursing

0250

Department of Legal Medicine

・・・・・・・・

22

8040

Maternity Nursing・Midwifery

・・・・・・・・

97

0260

Department of Medical Education

・・・・・・・・

23

8050

Pediatric Nursing

・・・・・・・・

98

Clinical Medicine

8060

Adult Nursing

・・・・・・・・

99

8070

Gerontological Nursing

・・・・・・・・

100

0300

Department of Cardiology

・・・・・・・・

24

8080

Community Health Nursing

・・・・・・・・

101

0310

Department of Respiratory Medicine

・・・・・・・・

26

8085

Psychiatric and Mental Health Nursing

・・・・・・・・

102

0320

Department of Gastroenterology

・・・・・・・・

28

8090

Home Care Nursing

・・・・・・・・

103

0325

Department of Hepatology

・・・・・・・・

30

8100

Medical Science・・・・・・・・

104

0330

Department of Nephrology

・・・・・・・・

32

0340

Department of Diabetology and Endocrinology

・・・・・・・・

34

0350

Department of Hematology and Immunology

・・・・・・・・

37

8610

Natural Science・・・・・・・・

106

0360

Department of Neurology

・・・・・・・・

40

8620

Human Science・・・・・・・・

108

0363

Department of Medical Oncology

・・・・・・・・

42

0675

Health Evaluation Center・・・・・・・・

110

7100

Department of Life Science・・・・・・・・

113

0366

Department of Infectious Diseases

・・・・・・・・

44

0368

Department of General Internal Medicine

・・・・・・・・

46

0370

Department of Geriatric Medicine

・・・・・・・・

48

0380

Department of Pediatrics

・・・・・・・・

49

0390

Department of Neuropsychiatry

・・・・・・・・

51

Department of General Education

University Hospital

Medical Research Institute

0400

Department of Radiology

・・・・・・・・

54

7200

Department of Advanced Medicine

・・・・・・・・

116

0412

Department of Cardiovascular Surgery

・・・・・・・・

56

7310

Division of Innovative Research・・・・・・・・

117

0415

Department of Thoracic Surgery

・・・・・・・・

57

7320

0420

Department of General and Digestive Surgery

・・・・・・・・

60

・・・・・・・・

120

0430

Department of Orthopedics Surgery

・・・・・・・・

62

0440

Department of Neurosurgery

・・・・・・・・

65

・・・・・・・・

125

0450

Department of Plastic and Reconstructive

7340

Surgery・・・・・・・・

67

Department of Pediatric Surgery

・・・・・・・・

69

0470

Department of Ophthalmology

・・・・・・・・

71

Division of Anticipatory Molecular Food Scienceand echnology

7350

0460

Division of Vision Research for Environmental
HealthDivision of Systems Bioscience for Drug
Discovery Based on Intrinsically Disordered

7400

Proteins

・・・・・・・・

128

Research Support Cente・・・・・・・・

129

Code

Depaertment

Page

Himi Municipal Hospital
9100

Himi Municipal Hospital・・・・・・・・

131

Code

Depaertment

Page

Basic Medical Science

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Associate Professor

SAKATA Hiromi

Developmental toxicology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Assistant Professor

TSUKADA Tsuyoshi

Developmental biology, Neuroscience, Neurosurgery

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis andneurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.

0100B002(Akai Takuya), Hatta Toshihisa, Shimada Hiroki, Mizuki Keiji, Kudo Nae, Hatta Taizo, Otani Hiroki:Extracranial
outﬂow of particles solved in cerebrospinal ﬂuid: Fluorescein injection study, Congenital Anomalies, 58:93-98,
2017.

- 1 -

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

HONMA Satoru

gross anatomy

Associate Professor

ITO Tetsufumi

neuroanatomy

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy

Assistant Professor

KOMINAMI Rieko

neuroanatomy

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, ontogenesis,
immunohistochemistry, electron microscopy, hippocampus, reconstruction, electron microscopy, vascularization,
Neuroanatomy, FIB/SEM, BMI, gustatory

Outline of Research
Theme of researches
1)Human gross anatomy
2)Neural network of the basal ganglia
3)Circuit of gustatory in the central nervous system
4)Tissue reconstruction and vascularization of human hippocampus

Publications
Originals
0110B001(Morita N), Ito T, Hasegawa RP, Murase K:Development of Functional Interlaminar Pathways in the Mouse
Superior Colliculus Revealed by Optical Imaging with Axonal Labeling, Journal of Biosciences and Medicines,
5:8;11-35, 2017.

0110B002(Mitsuhiro Matsuo), Satoru Honma, Takahiro Sonomura, Mitsuaki Yamazaki:Clinical anatomy of the cephalic veinfor safe performance of venipuncture, JA Clinical Reports, 3:50, 2017.

0110B003(Mamoru Uemura), Takamitsu Arakawa, Reiko Kominami, Satoru Honma, Akimichi Takemura:Identification of the
optimal method for removing the capsule from the acinus of the rat's mandibular glands when preparing specimens
for superficical morphology examination, Okajimas Folia Anat.Jpｎ., 94:3;109-113, 2017.

- 2 -

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Senior Assistant Professor

ONO Munenori

Neuroscience

Senior Assistant Professor

TAJIMA Nobuyoshi

molecular physiology

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal,
horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision,
intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released
or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron
excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellularmessenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic
efficiency and neuron excitability.

Publications
Originals
0120B001

Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis andneurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.

0120B002

Xianwen Luo, Yuan Shui, Furong Wang, Ryo Yamamoto, Nobuo Kato:Impaired retention of depression-likebehavior in a mouse model of Alzheimer's disease, IBRO Reports, 2:81-86, 2017.

0120B003

Munenori Ono, Deborah C Bishop, Douglas L Oliver:Identified GABAergic and Glutamatergic Neurons in the
Mouse Inferior Colliculus Share Similar Response Properties, The Journal of Neuroscience, 37:37;8952-8964, 2017.

Presentations at Conference
International Conference (Presentations)
0120I001

Ono M, Bishop DC, Oliver DL:Neuronal Sensitivity to the Interaural Time Difference, The 2nd International
Symposium on the Science of Mental Time, Nara, 2017.09.

- 3 -

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Professor

KURATA Yasutaka

Cardiac Electrophysiology

Associate Professor

TANIDA Mamoru

Circulatory Physiology

Assistant Professor

KUDA Yuｈichi

Circulatory Physiology

Keywords of Researchphysiology, circulatory shock, systemic anaphylaxis, pulmonary circulation, pulmonary edema, cardiac electrophysiology, ion
channels, pacemaker mechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis,
nonlinear dynamics, computer simulation, sympathetic nervous system, smooth muscle, vascular electrophysiology, artery,veinOutline of Research
Our works widely cover the area of cardiovascular physiology and autonomic nervous system. We are particularly interested
in the mechanisms of regulations of organ circulation under normal and anaphylactic conditions, and the mechanisms ofcardiac automaticity and arrhythmias as well as their regulations. We also explored the inhibitory effect of angiotensin II on
inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, the possible roles of pacemaker currents in robust
pacemaking and driving of biological pacemakers, and dynamical mechanisms of early afterdepolarizations in long QT
syndrome. We also aim to elucidate the central mechanisms for autonomic regulations of appetite-related hormones andcirculatory shock.

Publications
Originals
0130B001

Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T:Mouse
Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by
Sustained Renal Sympathoexcitation., Frontiers in Physiology, 8:669, 2017.

0130B002

Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T:Biphasic Renal
Sympathetic Response to Hemorrhagic Hypotension in Mice., Shock, 48:5;576-582, 2017.

0130B003

Kuda Y, Shibamoto T, Yang W, Zhang T, Tanida M, Kurata Y:Blockade of β2-adrenoceptor, rather than β1adrenoceptor, deteriorates cardiac anaphylaxis in isolated blood-perfused rat hearts., Cardiol J, 24:4;403-408,
2017.

0130B004

Kurata Y, Tsumoto K, Hayashi K, Hisatome I, Tanida M, Kuda Y, Shibamoto T:Dynamical mechanisms of phase-2
early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematicalmodels., Am J Physiol Heart Circ Physiol, 312:1;H106-H127, 2017.

0130B005(Tsumoto K), Kurata Y, Furutani K, Kurachi Y:Hysteretic dynamics of multi-stable early afterdepolarisations with
repolarisation reserve attenuation: a potential dynamical mechanism for cardiac arrhythmias., Sci Rep, 7:1;10771,
2017.

- 4 -

0130B006(Ohnohara T), Hisatome I, Kurata Y, Li P, Notsu T, Morikawa K, Otani N, Yoshida A, Iitsuka K, Kato M, Miake J,
Ninomiya H, Higaki K, Shirayoshi Y, Nishihara T, Itoh T, Nakamura Y, Nishimura M:Molecular mechanism
underlying the pilsicainide-induced stabilization of hERG proteins in transfected mammalian cells., J Arrhythm,
33:3;226-233, 2017.

0130B007(Ikeda N), Nakazawa N, Kurata Y, Yaura H, Taufiq F, Minato H, Yoshida A, Ninomiya H, Nakayama Y, Kuwabara
M, Shirayoshi Y, Hisatome I:Tbx18-positive cells differentiated from murine ES cells serve as proepicardial
progenitors to give rise to vascular smooth muscle cells and fibroblasts., Biomed Res, 38:4;229-238, 2017.

0130B008(Ho YY), Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, Ohinata K:l-Ornithine stimulates growth
hormone release in a manner dependent on the ghrelin system., Food Funct, 8:6;2110-2114, 2017.

0130B009(Yamamoto N), Shibata M, Ishikuro R, Tanida M, Taniguchi Y, Ikeda-Matsuo Y, Sobue K:Epigallocatechin gallate
induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes throughactivation of ERK and PI3K pathways., Neuroscience, 362:70-78, 2017.

Presentations at Conference
International Conference (Presentations)
0130I001

Tanida M, Shibamoto T:Biphasic response of renal sympathetic nerve to hemorrhagic shock in anesthetized mice.,
The 40th Annual Conference on Shock, Florida, 2017.

0130I002

Shibamoto T, Yang W, Kuda Y, Zhang T, Tanida M, Kurata Y:β2-adrenoceptor blockade augments anaphylaxisinduced increase in pulmonary vascular permeability in anesthetized mice., European Respiratory SocietyInternational Congress 2017, Milan, 2017.

0130I003

Shibamoto T, Wang M, Kuda Y, Zhang T, Yang W, Tanida M, Kurata Y:Systemic hypertension-induced left atrial
pressure elevation accounts for the pathogenesis of neurogenic pulmonary edema in anesthetized rats., The 22nd
Asian Pacific Society of Respirology Congress 2017, Sydney, 2017.

- 5 -

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SAKASAI Ryo

DNA damage response induced by anti-cancer drugs

Assistant Professor

SUNATANI Yumi

Function of DNA damage repair protein

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

Ryo Sakasai, Mayu Isono, Mitsuo Wakasugi, Mitsumasa Hashimoto, Yumi Sunatani, Tadashi Matsui, Atsushi
Shibata, Tsukasa Matsunaga, Kuniyoshi Iwabuchi:Aquarius is required for proper CtIP expression and homologous
recombination repair, SCIENTIFIC REPORTS, 7:13808, 2017.

- 6 -

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Senior Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Assistant Professor

TAKATSUJI-SAITO
Hidehito

neuroscience, molecular biology, regenerative medicine

Faculty

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor,

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis andneurovascular parallel alignment in mouse embryonic skin, Journal of Cell Science, 130:5;916-926, 2017.

0150B002

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

Presentations at Conference
International Conference (Symposium)
0150H001(Y.Yamada), K.Sakai, Y.Chiba, B.Hev, D.Mahboubi, CraigRhodes, Y.Yoshitomi, S. Fukumoto, T.Nakamura:
Epiprofin is a multi-functional factor essential to promote dental epithelial stem cell commitment to the ameloblast
lineage and its proliferation and differentiation, The 2017 Japan-NIH joint Symposium on Advances in Biomedical
Research and Disease, Sendai, 2017.

- 7 -

0160

Department of Pharmacology

Faculty
Title

Name

Professor

ISHIBASHI Takaharu

Professor
Associate Professor
Senior Assistant Professor

Field of Specialization

Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemElectrophysiological and pharmacological study of excitable and nonNISHIO Matomo
excitable cells, Pharmocology of cardiovascular drugs
Electrophysiology and behavioural pharmacology in central and
MASUOKA Takayoshi
periphenal nervous system

TAWA Masashi

Cardiovascular pharmacology

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitricoxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation,
cell biology, hippocampal synapses, muscarinic acetylcholine receptor, peripheral sensory neuron, autonomic neuron,central nervous system, metabotropic glutamate receptor, receptorology,

Outline of Research
1 Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
2 Signaling mechanisms of bioactive substances
3 Electropharmacology of the drugs acting on the cardiovascular system
4 Pharmacological study of the ischemic cardiomyocytes
5 Kinetics of NO(nitric oxide)-related compounds in cardiovascular system
6 Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation

Publications
Originals
0160B001

Masuoka Takayoshi, Kudo Makiko, Yamashita Yuka, Yoshida Junko, Imaizumi Noriko, Muramatsu Ikunobu, Nishio
Matomo, Ishibashi Takaharu:TRPA1 Channels Modify TRPV1-Mediated Current Responses in Dorsal Root
Ganglion Neurons, FRONTIERS IN PHYSIOLOGY, 8:1-9, 2017.

0160B002

Muramatsu Ikunobu, Uwada Junsuke, Masuoka Takayoshi, Yoshiki Hatsumi, Sada Kiyonao, Lee Kung-Shing, Nishio
Matomo, Ishibashi Takaharu, Taniguchi Takanobu:Regulation of synaptic acetylcholine concentrations byacetylcholine transport in rat striatal cholinergic transmission, JOURNAL OF NEUROCHEMISTRY, 143:1;76-86,
2017.

- 8 -

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Senior Assistant Professor

HIRATA Eishu

Tumour cell biology, Neurosurgery

Assistant Professor

ICHIKAWA Takehiko Fluorescent Imaging

Assistant Professor

KOBAYASHI Ryosuke Reproductive medicine

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration,

Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer
development and invasion/metastasis, and epithelial regeneration.We also develop the system to manipulate cell signaling tounderstand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating roles of
DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.

Publications
Originals
0170B001

E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ
regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.

0170B002

Haruna Takeda, Etsuko Kiyokawa:Activation of Erk in ileal epithelial cells engaged in ischemic-injury repair,
Scientific Reports, 7:16469, 2017.

0170B003(Asako Sasahara), Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni
Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko
Gotoh:An autocrine / paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance ofbreast cancer stem-like cells, Oncotarget, 8:15;24869-24881, 2017.

0170B004

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

Reviews
0170C001

Hirata E, Sahai E:Tumor Microenvironment and Differential Responses to Therapy., Cold Spring Harbor
Perspectives in Medicine, 7:a026781, 2017.

Presentations at Conference
International Conference (Presentations)
0170I001

Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene
expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.

- 9 -0170I002

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.

0170I003

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.

- 10 -

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Diagnostic pathology of tumor

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchlung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic histopathology, phospholipid,
regeneration of cartilage, steroid induced femoral neuritis, mesenchymal stem cell, matrix metalloproteinase, bone tumor,
molecular genetics, molecular pathology, neuronal death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand,
NFκB

Outline of Research
1. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
2. Molecular pathological diagnosis by FISH using probes origination from BAC clones and RT-PCR methods.
3. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.

Publications
Originals
0180B001(Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi,
Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma, Annals of nuclear medicine, 31:590-595, 2017.

0180B002

Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Masanobu Tuchiya, Ayumi Kaneuji, Norio Kawahara:Involvement of
necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model, International
journal of medical sciences, 14:110-114, 2017.

0180B003

Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio
Kawahara:Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal
stem cells in a rabbit model, BMC musculoskeletal disorders, 18:480, 2017.

Reviews
0180C001

Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi
Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging(DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.

Case Reports
0180D001

Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko
Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient withtuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.

- 11 -

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

HIGUCHI Masaya

Virology, Hematology, Oncology, Cellular biology

Associate Professor

HIMEDA Toshiki

Neurovirology

Assistant Professor

OKUWA Takako

Neurovirology

Assistant Professor

UTANI Koh-ichi

Cellular biology

Keywords of Research
Ubiquitin specific peptidase 10, Theiler’s virus, Saffold virus,

Outline of Research
Functional analysis of the deubiquitinating enzyme USP10 in stress response and innate immunity. Mechanism of persistentinfection and pathogenesis of Theilovirus (Theiler's virus and Saffold virus).

Publications
Originals
0190B001

Okuwa Takako, Sasaki Yutaka, Matsuzaki Yoko, Himeda Toshiki, Yoshino Naoto, Hongo Seiji, Ohara Yoshiro,
Muraki Yasushi:The epitope sequence of S16, a monoclonal antibody against influenza C virus hemagglutininesterase fusion glycoprotein, FUTURE VIROLOGY, 12:3;93-101, 2017.

Reviews
0190C001

Masaya Higuchi:Regulation of intracellular stress responses by the pleiotropic deubiquitinase USP10, Journal of
Kanazawa Medical University, 42:2;41-47, 2017.

Short Communications
0190E001(Ito Hisato), Miyagaki Satoshi, Sakaue Satoshi, Matsui Fumihiro, Katsumi Yoshiki, Otabe Osamu, Torii Jun, Itagaki
Tsutomu, Himeda Toshiki, Okuwa Takako, Ohara Yoshiro:Saffold Cardiovirus Infection in a 2-Year-Old Boy with
Acute Pancreatitis, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:1;105-107, 2017.

- 12 -

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

ONAI Nobuyuki

Professor(Additional Post)

KOHNO Hiroyuki

Senior Assistant Professor

YABE-WADA Toshiki Immunology, Functional biochemistry, Structural biochemistry

Assistant Professor

MATSUBA Shintaro

Experimental Pathology, Tumor immunology

Immunological pharmacology

Keywords of Research
The origin, development, and function of mononuclear phagocytes, Dendritic cells, Monocytes/Macrophages, Allergic
effector cells, Innate immune responses, Cytokines

Outline of Research
Our research is focused on the regulation mechanisms of various immune responses.In the years, we have characterized
several proteins that are involved in cytokine trafficking and the regulation of serine protease activity using mouse models.
Specific areas of interest include; The origin, development, and function of mononuclear phagocytes (dendritic cells,
monocytes, and macrophages). The regulation of cytokine production from innate immune cells. The role of endogenous
serine protease inhibitors in allergic effector cells.

Publications
Originals
0200B001

S.Matsuba, T.Yabe-Wada, K.Takeda, T.Sato, M.Suyama, T.Takai, T. Kikuchi, T. Nukiwa, A.Nakamura:
Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells,
FRONTIERS IN IMMUNOLOGY, 8:1538, 2017.

0200B002

Nobuyuki Onai, Jumpei Asano, Rumiko Kurosaki, Shoko Kuroda, Toshiaki Ohteki:Flexible fate commitment of E22high common DC progenitors implies tuning in tissue microenvironments, International Immunology, 29:10;443456, 2017.

Presentations at Conference
International Conference (Presentations)
0200I001

Toshiki Yabe-Wada, Shintaro Matsuba, Kazuya Takeda, Akira Nakamura, Caroline C Philpott, Nobuyuki
Onai:Involvement of poly-rC binding proteins in posttranscriptional regulation of Sortilin, the cytokine trafficking
mediator, The 5th Annual Meeting of the International Cytokine and Interferon Society, Kanazawa, 2017.

0200I002

Nobuyuki Onai, Toshiaki Ohteki:Identification of Flt3-ligand producing cells by generating Flt3-ligand mCherry
reporter mouse, 5th Annual Meeting of the international Cytokine and Interferon Society, Kanazawa, 2017.10.

- 13 -

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Associate Professor

MURAKAMI Manabu

Infection-mediated arthropod

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium, Japanese encephalitis Virus, mosquito, Culex tritaeniorhynchus, Culex tritaeniorhynchus, Aedes
albopictus

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Investigation of mosquito situation around the pigpen in Ishikawa prefecture, and JE virus distribution.

Publications
Originals
0210B001

Murakami Manabu, Hori Kiyoe, Kitagawa Yoko, Oikawa Yosaburo, Kamimura Kiyoshi, Takagemi Tsutomu:An
Ecological Survey of Mosquitoes and the Distribution of Japanese Encephalitis Virus in Ishikawa Prefecture, Japan,
between 2010 and 2014, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:4;362-367, 2017.

0210B002

Iwabu-Itoh Yukie, Bazartseren Boldbaatar, Naranbaatar Oyunnomin, Yondonjamts Enkhmandakh, Furuno Kiwa,
Lee Kyunglee, Sato Kozue, Kawabata Hiroki, Takada Nobuhiro, Andoh Masako, Kajita Hiroko, Oikawa Yosaburo,
Nakao Minoru, Ohnishi Makoto, Watarai Masahisa, Shimoda Hiroshi, Maeda Ken, Takano Ai:Tick surveillance for
Borrelia miyamotoi and phylogenetic analysis of isolates in Mongolia and Japan., Ticks and Tick-borne Diseases,
8:6;850-857, 2017.

Others0210F001(Shin-ichi Hiramatsu), Yosaburo Oikawa:Records of ticks in Kaga area, Ishikawa Prefecture, 43:29-32, 2017.

- 14 -

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

MINATO Hiroshi

Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Senior Assistant Professor

NAKADA Satoko

surgical pathology

Assistant Professor

KOBAYASHI Erikosurgical pathology, molecular pathology

Assistant Professor

SHIOYA Akihiro

Surgical pathology

Assistant Professor

AIKAWA Akane

Surgical pathology

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, lung, mediastinum, and pleura, head and neck, salivary gland

Outline of Research
Since atherosclerosis and its complications account for approximately up to 30% of cause of human death in the whole world,
it is very critical to overcome this issue from the economical as well as medical aspects. I first focused on thehistopathological viewpoints that the initiation to progression of atherosclerosis basically depends on inflammatory response.
In order to elucidate its mechanism, I have thoroughly performed the in vivo experiments together with the extensively
morphological to biochemical and molecular analyses from the wide view, by using various genetically modified animal modelsof mice or rabbits. Furthermore, I recently aim to multidimensionally and comprehensively re-evaluate these chronic
inflammatory diseases including some kinds of malignancy, via overlooking the entity of metabolic syndrome, manifesting as
not only atherosclerosis but diabetes mellitus (DM) or non-alcoholic steatohepatitis (NASH).

Publications
Originals
0220B001

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

Case Reports
0220D001

Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda
Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic
erythroderma: a case report., Journal of medical case reports, 11:1;35, 2017.

Short Communications
0220E001

Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi
Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.

- 15 -

Presentations at Conference
International Conference (Symposium)
0220H001

Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective lowpressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society ofThyroid Surgery, Naha, 2017.11.

International Conference (Presentations)
0220I001

A.Hiroguchi, Y.Osaka, J.Sakamoto, T.Shibata, H.Minato, T.Sasagawa:Identification of HPV infection type for
Squamous cell carcinoma, 31th International Papillomavirus Conference, Capetown, 2017.02.

0220I002

Seiko Miura, Nobuhiko.Ueda, Toshio.Onishi, Yasuto.Tomita, Hideto.Fujita, Shinichi.Kinami, Yasuharu.Nakano,Takeo.Kosaka, Akane.Aikawa, Hiroshi.Minato, Takayuki.Nojima:Multilocular cystic intrahepaticcholangiocarcinoma:A case report, Joint Congress of The 6th Biennial Congress of the Asian-Pacific HepatoPancreato-Billiary Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery,
Yokohama, 2017.06.

0220I003

Nobuhiko Ueda, Seiko Miura, Yasuto Tomita, Toshio Onishi, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano,Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Surgical management of intraducyal papillary
mucinous neoplasms, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Billiary
Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.

- 16 -

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

ISHIZAKI Masao

Occupational Health, Job stress

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Assistant Professor

HORI Kaori

Pediatirc cardiology

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, TeruhikoKido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin,
insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental andclinical endocrinology & diabetes, 125:1;12-20, 2017.

0230B002

M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse,
K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body massindex and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.

0230B003(Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of
tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.

0230B004(Rie Oka), Kyoko Shibata, Masaru Sakurai, Mitsuhiro Kometani, Masakazu Yamagishi, Kenichi Yoshimura, Takashi
Yoneda:Trajectories of postload plasma glucose in the development of type 2 diabetes in Japanese adults, Journalof Diabetes Research, 2017:5307523, 2017.

0230B005(Toshinari Takamura), Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai,
Takeshi Urabe, Shuichi Kaneko:Weight-adjusted lean body mass and calf circumference are protective against
obesity-associated insulin resistance and metabolic abnormalities, Heliyon, 3:7;e00347, 2017.

0230B006(Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono:
Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.

0230B007

K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selectionof Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on thePatients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.

0230B008(Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.

- 17 -

Presentations at Conference
International Conference (Presentations)
0230I001

Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi
Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-yearchange of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.

- 18 -

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NISHINO Yoshikazu

Epidemiology of cancer, preventive medicine

Professor

NISHIJO Muneko

Environmental epidemiology, Environmental health sciences,
Epidemiology of cadmium pollution

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Senior Assistant Professor

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Keywords of Research
epidemiology, public health, cancer, hypertension, diabetes mellitus, screening, shift work, nutrition, calcium, stress,smoking, insulin resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractabledisease, cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid
peroxide, community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono:Estimationof Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants ofan Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.

0240B002(Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, TeruhikoKido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin,
insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental andclinical endocrinology & diabetes, 125:1;12-20, 2017.

0240B003

M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse,
K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body massindex and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.

0240B004(Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le,
Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin
exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.

0240B005(Junya Sado), Tetsuhisa Kitamura, Yuri Kitamura, Ling Zha, Rong Liu, Tomotaka Sobue, Yoshikazu Nishino, Hideo
Tanaka, Tomio Nakayama, Ichiro Tsuji, Hidemi Ito, Takaichiro Suzuki, Kota Katanoda, Suketami Tominaga, for theThree-Prefecture Cohort Studu Group:Rationale, design, and profile of the Three-Prefecture Cohort in Japan: A
15-year follow-up, Journal of Epidemiology, 27:4;193-199, 2017.

- 19 -

0240B006(Yoichiro Kakugawa), Hiroshi Tada, Masaaki Kawai, Takashi Suzuki, Yoshikazu Nishino, Seiki Kanemura, Takanori
Ishida, Noriaki Ohuchi, Yuko Minami:Associations of obesity and physical activity with serum and intratumoral sex
steroid hormone levels among postmenopausal women with breast cancer:analysis of paired serum and tumor tissue
samples, Breast Cancer Res Treat, 162:1;115-125, 2017.

0240B007(K.Sugiyama), Y.Sugawara, Y.Tomata, Y.Nishino, A.Fukao, I.Tsuji:The association between coffee consumption andbladder cancer incidence in a pooled analysis of the Miyagi Cohort Study and Ohsaki Cohort Study., European
journal of cancer prevention, 26:2;125-130, 2017.

0240B008

Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn,
Yoshikazu Nishino:Gender-specific impact of cadmium exposure on bone metabolism in older people living in a
cadmium-polluted area in Thailand, International Journal of Envitronmental Research and Publich Health, 14:4;401,
2017.

0240B009

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano,Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

0240B010

Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death inpatients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of afollow-up study in Japan, BMJ Open, 7:7;e015694, 2017.

0240B011(Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira,Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura
Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels ofhigh-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology,
32:547-557, 2017.

0240B012(H.Nakagawa), H.Ito, S.Hosono, I.Oze, H.Mikami, M.Hattori, Y.Nishino, H.Sugiyama, K.Nakata, H.Tanaka:
Changes in trends in colorectal cancer incidence rate by anatomic site between 1978 and 2004 in Japan., European
journal of cancer prevention, 26:4;269-276, 2017.

0240B013(Xian Liang Sun), Teruhiko.Kido, Seijiro.Honma, Eitetsu.Koh, Rie.Okamoto, Ho Dung Manh, Shoko.;Maruzeni,
Muneko.Nishijo, Hideaki.Nakagawa, , Takeshi.Nakano, Takumi.Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le
Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.

0240B014(Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai
Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli
Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Muneko Nishijo, Kido Teruhiko,Tai Pham-The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives,
Epidemiology (Cambridge, Mass.), 28:Suppl 1;19-34, 2017.

0240B015(J.Sado), T.Kitamura, Y.Kitamura, T.Sobue, Y.Nishino, H.Tanaka, T.Nakayama, I.Tsuji, H.Ito, T.Suzuki,
K.Katanoda, S.Tominaga, Three-Prefecture Cohort Study Group:Association between coffee consumption and allsites cancer incidence and mortality, Cancer Science, 108:10;2079-2087, 2017.

0240B016(Kathryn Demanelis), Shama Virani, Justin A. Colacino, Niladri Basu, Muneko Nishijo, Werawan Ruangyuttikarn,
Witaya Swaddiwudhipong, Kowit Nambunmee, Laura S. Rozek: Cadmium exposure and age-associated DNA
methylation changes in non-smoking women from northern Thailand, Environmental Epigenetics, 3:2;dvx006, 2017.

- 20 -

Presentations at Conference
International Conference (Presentations)
0240I001

Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi
Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-yearchange of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.

0240I002

Muneko Nishijo, Hideaki Nakagawa, Kazuhiro Nogawa, Yasushi, Suwazono, Teruhiko Kido:Cancer mortality ofresidents living in the cadmium-polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the
Biogeochemistry of Trace Elements, Zurich, 2017.07.

0240I003

Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.12.

- 21 -

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

MIZUKAMI Hajime

Legal Medicine,Forensic pathology,DNA polymorphism

Assistant Professor

KOBAYASHI
Masamune

Legal medicine,DNA polymorphism

Assistant Professor

TAKESHITA Hiroshi

Legal medicine,Forensic pathology

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K,

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001

Hara Shuichi, Kobayash Masamune, Kuriiwa Fumi, Kurosaki Kunihiko, Mizukami Hajime:Gene expression in rat
striatum following carbon monoxide poisoning, Genomics data, 12:74-75, 2017.

- 22 -

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

HORI Ariyuki

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning

Senior Assistant Professor

TAKAMURA Akiteru

Comunity-based Medical Education, Simulated education

Senior Assistant Professor

KURODA Naohiro

medical informatics, electronic medical record system, medical
educatin

Faculty

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL,

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Originals
0260B001

Takamura Akiteru, Ito Sayori, Maruyama Kaori, Ryo Yusuke, Saito Manami, Fujimura Shuhei, Ishiura Yuna, Hori
Ariyuki:Quality of basic life support education and automated external defibrillator setting in schools in Ishikawa,Japan, PEDIATRICS INTERNATIONAL, 59:3;352-356, 2017.

0260B002

Takamura Akiteru, Misaki Hidekazu, Takemura Yousuke, Community and Interns' Perspectives on CommunityParticipatory Medical Education: From Passive to Active Participation, Family medicine, 49:7;507-513, 2017.

Reviews
0260C001

A.Takamura, M.Matsumoto, S.Ishikawa.:Rural Health in Japan: Past and future., Rural and Remote Health,
17:4;4521, 2017.

Case Reports
0260D001

Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri
without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.

0260D002

A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated byrenal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.

0260D003

Akiteru Takamura, Ariyuki Hori:Recurrent Translent Perivascular Inflammation of the Carotid artery syndrome
with temporary carotid plaque on ultrasonography: a case report, Clinical Case Reports, 5:11;1847-1851, 2017.

- 23 -

Clinical Medicine

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

Associate Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Associate Professor(Additional Post)

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Senior Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

WATANABE Makoto

Ischemic heart disease, Coronary intervention

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Assistant Professor

TAKANO Shintaro

Arrhythmai, Catheter ablation

Assistant Professor

TAKAMURA Takaaki Ischemic heart disease, Coronary intervention

Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

KITAGAWA Katsuhide Ischemic heart disease, Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
1 Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
2 Development of new therapeutics using the gene expression modification or the stem cell research technique
3 Visualization and quantification of the biological signal in cardiovascular system- 24 -

Publications
Originals
0300B001

Kamioka Norihiko, Soga Yoshimitsu, Kuramitsu Shoichi, Iida Osamu, Hirano Keisuke, Suzuki Kenji, Kawasaki
Daizo, Yamaoka Terutoshi, Suematsu Nobuhiro, Shintani Yoshiaki, Miyashita Yusuke, Takahashi Hiroki, Tsuchiya
Taketsugu, Shinozaki Norihiko, Okazaki Shinya, Ando Kenji:Clinical outcomes of balloon angioplasty alone versus
nitinol stent implantation in patients with small femoropopliteal artery disease: Observations from theRetrospective Multicenter Analysis for Femoropopliteal Stenting (REAL-FP), Catheterization and cardiovascularinterventions, 90:5;790-797, 2017.

0300B002(K.Suzuki), Y.Mizutani, Y.Soga, O.Iida, D.Kawasaki, Y.Yamauchi, K.Hirano, R.Koshida, D.Kamoi, J.Tazaki,
M.Higashitani, Y.Shintani, T.Yamaoka, S.Okazaki, N.Suematsu, T.Tsuchiya, Y.Miyashita, N.Shinozaki,
H.Takahashi, N.Inoue:Efficacy and Safety of Endovascular Therapy for Aortoiliac TASC D Lesions., Angiology,
68:1;67-73, 2017.

0300B003

M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi,
T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severityof coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.

0300B004

Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao
Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density
lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.

0300B005

Tanabe Nobuhiro, Ikeda Satoshi, Tahara Nobuhiro, Fukuda Keiichi, Hatano Masaru, Ito Hiroshi, Nakayama
Tomotaka, Anzai Toshihisa, Hashimoto Akiyoshi, Inoue Teruo, Kajinami Kouji, Kihara Yasuki, Kinoshita Hideyuki,
Kuwahara Koichiro, Murohara Toyoaki, Okazaki Osamu, Sakai Satoshi, Satoh Toru, Takeda Yutaka, Takeishi
Yasuchika, Taniguchi Mitsugu, Watanabe Hiroshi, Yamamoto Takeshi, Yamauchi-Takihara Keiko, Yoshioka
Koichiro, Sasayama Shigetake:Efficacy and Safety of an Orally Administered Selective Prostacyclin Receptor
Agonist, Selexipag, in Japanese Patients With Pulmonary Arterial Hypertension, CIRCULATION JOURNAL,
81:9;1360-1367, 2017.

0300B006

Soga Yoshimitsu, Takahara Mitsuyoshi, Iida Osamu, Yamauchi Yasutaka, Hirano Keisuke, Fukunaga Masashi, Zen
Kan, Suzuki Kenji, Shintani Yoshiaki, Miyashita Yusuke, Tsuchiya Taketsugu, Yamaoka Terutoshi, Ando Kenji:
Efficacy of CilostAzol for Below-the-Knee Artery Disease after Balloon AnGioplasty in PatiEnts with Severe Limb
Ischemia (CABBAGE Trial), Annals of vascular surgery, 45:22-28, 2017.

- 25 -

0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Professor

ISHIZAKI Takeshi

Pulmonary circulation

Associate Professor

MIZUNO Shirolung cell and molecular biology，COPD

Associate Professor(Additional Post)

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Senior Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

KAMEDA Mari

clinical respiratory medicine

Assistant Professor

SHINOMIYA Shohei

clinical respiratory medicine

Assistant Professor

KATO Ryochronic obstructive pulmonary disease

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001

Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito,
Yuki Fujimoto, Shiro Mizuno, Hirohisa Toga:Exogenous gene transfer of Rab38 small GTPase ameliorates aberrant
lung surfactant homeostasis in Ruby rats, Respiratory Research, 18:70, 2017.

0310B002

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

- 26 -

0310B003

Shiro Mizuno, Takeshi Ishizaki, Maiko Kadowaki, Masaya Akai, Kohei Shiozaki, Masaharu Iguchi, Taku Oikawa,
Ken Nakagawa, Kazuhiro Osanai, Hirohisa Toga, Jose Gomez-Arroyo, Donatas Kraskauskas, Carlyne D Cool,
Herman J Bogaard, Norbert F voelkel:p53 Signaling Pathway Polymorphisms Associated With Emphysematous
Changes in Patients With COPD, CHEST, 152:1;58-69, 2017.

Case Reports
0310D001

Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri
without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.

0310D002

Yutaka Takahara, Ryo Kato, Ken Nakagawa, Shiro Mizuno, Kazuhiro Osanai, Hirohisa Toga:A case of pulmonary
arteriovenous malformation having difficulty in differential diagnosis of the hemoptysis during each menstrual
period, Annals of the Japanese Respiratory Society, 6:3;215-219, 2017.

Presentations at Conference
International Conference (Presentations)
0310I001

K.Nishiki, S.mizuno, M.Nojiri, T.Oikawa, K.Nakagawa,K.Osanai, T.Ishizaki, H.Toga:Serum Creatinine Levels
Referenced By Cystatin C Are Ａssociated With Disease Severity In Patients With COPD, American Thoracic
Society 2017 International Conference, Washington,D.C., 2017.05.

0310I002

M.Nojiri, S.Mizuno, T.Oikawa, K.Nakagawa, K.Osanai, T.Ishizaki, H.Toga:Effect Of Emphysema Heterogeneity
And Adrb2 Polymorphisms On Bronchodilator Response In Patients With COPD, American Thoracic Society 2017
International Conference, Washington,D.C., 2017.05.

0310I003

K.Osanai, M.Zhou, T.Sakuma, K.Nakase, M.Nojiri, S.Mizuno, H.Toga:Exogenous Expression of
Lysophosphatidylcholine Acyltransferase 1 Attenuates Oleic Acid-induced Acute Lung Injury in Rats, FASEB
Science Research Conference, New Orleans, 2017.08.

- 27 -

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Associate Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Associate Professor(Additional Post)SHIMASAKI Takeo

Molecular Oncology, Pancreatic cancer , tissue engineering．

Senior Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Senior Assistant Professor

HAYASHI Ranji

Inflammatory Bowel Disease

Assistant Professor

NOMURA Tomoe

Gastro-intestinal disorders

Assistant Professor

OOTA Masafumi

Gastro-intestinal disorders

Faculty

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
1 Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
2 Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0320B001

Toshikuni Nobuyuki, Tsuchishima Mutsumi, Fukumura Atsushi, Arisawa Tomiyasu, Tsutsumi Mikihiro:Associationsof Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic andNonalcoholic Steatohepatitis, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017:9127847, 2017.

0320B002

Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi
Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki:
Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.

- 28 -

Presentations at Conference
International Conference (Symposium)
0320H001

Tomiyasu Arisawa:Genetic alterations in FD patients, ANMA&JSNM Joint Meeting 2017, Osaka, 2017.03.

International Conference (Presentations)
0320I001

Tomiyasu Arisawa, Hikaru Takano, Tasuku Hayashi, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi,
Toshimi Otsuka, Takeo Shimasaki, Masakatsu Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATIONIN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.

- 29 -

0325

Department of Hepatology

Faculty
Title

Name

Field of Specialization

Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Associate Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Associate Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Senior Assistant Professor

SAITO Takashi

Treament for metabolic syndrome

Senior Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

MATSUE Yasuhiro

Mechanism of liver cancer

Assistant Professor

MINATO Takahiro

Mechanism of non-alcoholic steatohepatitis

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis, regenerative medicine,stem cell, adipose tissue

Outline of Research
1 Basic and clinical study of digestive disease(1)Treatment for esophageal and gastric varices associated with portal hypertension(2)Hepatic support system for severe alcoholic hepatitis(3)Clinical feature and treatment for nonalcoholic steatohepatitis
2 Experimental study of alcoholic organ injury(1)Pathogenesis and treatment for alcoholic hepatitis(2)Pathogenesis of hepatic fibrosis induced by alcohol(3)Effect of alcohol on chemical carcinogenesis of the liver
3 Pathogenesis for nonalcoholic steatohepatitis
4 Regenerative medicine(1)Regenerative of hepatic cell(2)Regenerative of mucosa on esophagus and stomach(3)Development of sheet for stem cell

- 30 -

Publications
Originals
0325B001

Toshikuni Nobuyuki, Tsuchishima Mutsumi, Fukumura Atsushi, Arisawa Tomiyasu, Tsutsumi Mikihiro:Associationsof Fatty Liver Disease with Hypertension, Diabetes, and Dyslipidemia: Comparison between Alcoholic andNonalcoholic Steatohepatitis, GASTROENTEROLOGY RESEARCH AND PRACTICE, 2017:9127847, 2017.

0325B002

Toshikuni Nobuyuki:Therapy with Direct-Acting Antiviral Agents for Hepatitis C-Related Liver Cirrhosis, GUT
AND LIVER, 11:3;335-348, 2017.

0325B003

Toshikuni Nobuyuki, Matsue Yasuhiro, Ozaki Kazuaki, Yamada Kaho, Hayashi Nobuhiko, Tsuchishima Mutsumi,
Tsutsumi Mikihiro:An image fusion system for estimating the therapeutic effects of radiofrequency ablation on
hepatocellular carcinoma, RADIOLOGY AND ONCOLOGY, 51:3;263-269, 2017.

0325B004

George Joseph, Tsutsumi Mikihiro, Tsuchishima Mutsumi:MMP-13 deletion decreases profibrogenic molecules andattenuates N-nitrosodimethylamine-induced liver injury and fibrosis in mice, JOURNAL OF CELLULAR AND
MOLECULAR MEDICINE, 21:12;3821-3835, 2017.

Reviews
0325C001

Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi:Toxic AGE(TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Nutrients, 9:634, 2017.

Presentations at Conference
International Conference (Presentations)
0325I001

J.George, N.Hayashi, T.Saito, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi:Nanovesicle mediated deliveryof combination of anticancer agents effectively induced cell death in Hepatocellular carcinoma cell lines,
International Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver,
Amsterdam, 2017.04.

0325I002

Joseph George, Nobuhiko Hayashi, Takashi Saito, Kazuaki Ozaki, Nobuyuki Toshikuni, Mutsumi Tsuchishima,
Mikihiro Tsutsumi:Deletion of survivin sensitize human hepatocellular carcinoma cells to low dose of doxorubicinand induce apoptosis, AACR Annual Meeting 2017, Washington,D.C., 2017.04.

0325I003

Nobuyuki Toshikuni, Yasuhiro Matsue, Kazuaki Ozaki, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro
Tsutsumi:Real-Time Image fusion for estimating the therapeutic effects of radiofrequency ablation on hepatocellular
carcinoma, Digestive Disease Week 2017, Chicago, 2017.05.

0325I004

Kaori Kinoshita, Nobuyuki Toshikuni, Mutsumi Tsuchishima, Mikihiro Tsutsumi:The effects of moderate drinking
on liver fibrosis progression in subjects with fatty liver disease, Digestive Disease Week 2017, Chicago, 2017.05.

0325I005

Joseph George, Nobuhiko Hayashi, Mutsumi Tsuchishima, Mikihiro Tsutsumi:Inhibition of γ-Glutamyltranspeptidase attenuates hepatic ischemia-reperfusion injury in rats, Digestive Disease Week 2017, Chicago,2017.05.

- 31 -

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Senior Assistant Professor

ADACHI Hiroki

Clinical nephrology

Senior Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Assistant Professor

OKINO Kazuaki

Clinical nephrology

Assistant Professor

MUKAI Kiyotaka

Clinical nephrology

Assistant Professor

OKUSHI Yuki

Clinical nephrology

Assistant Professor

OKADA Keiichirou

Assistant Professor

NAKAYAMA Kanae

Assistant Professor

MATSUURA
Toshikazu

Assistant Professor

KUBO Yukimi

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

- 32 -

Publications
Originals
0330B001(Saito T), Iwano M, Matsumoto K, Mitarai T, Yokoyama H, Yorioka N, Nishi S, Yoshimura A, Sato H, Ogahara S,
Sasatomi Y, Kataoka Y, Ueda S, Koyama A, Maruyama S, Nangaku M, Imai E, Matsuo S, Tomino Y:Mizoribine
therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous
nephropathy with steroid-resistant nephrotic syndrome, Clinical and Experimental Nephrology, 21:961-970, 2017.

0330B002(Hiromura K), Ikeuchi H, Kayakabe K, Sugiyama H, Nagata M, Sato H, Yokoyama H, Nojima Y:Clinical andhistological features of lupus nephritis in Japan: A cross-sectional analysis of the Japan Renal Biopsy Registry (JRBR), Nephrology (Carlton), 22:885-891, 2017.

0330B003(Nishi S), Muso E, Shimizu A, Sugiyama H, Yokoyama H, Ando Y, Goto S, Fujii H:A clinical evaluation of renal
amyloidosis in the Japan renal biopsy registry: a cross-sectional study, Clinical and Experimental Nephrology,
21:624-632, 2017.

0330B004(Uemura O), Yokoyama H, Ishikura K, Gotoh Y, Sato H, Sugiyama H, Honda M, Matsuo S:Performance inadolescents of the two Japanese serum creatinine based estimated glomerular filtration rate equations, for adults
and paediatric patients: A study of the Japan Renal Biopsy Registry and Japan Kidney Disease Registry from 2007
to 2013, Nephrology (Carlton), 22:494-497, 2017.

0330B005

Okushi Y, Okino K, Mukai K, Matsui Y, Hayashi N, Fujimoto K, Adachi H, Yamaya H, Yokoyama H:Circulating
and renal expression of HLA-G prevented chronic renal allograft dysfunction in Japanese recipients, Clinical andExperimental Nephrology, 21:932-940, 2017.

0330B006

K.Okino, Y.Okushi, K.Mukai, Y.Matsui, N.Hayashi, K.Fujimoto, H.Adachi, H.Yamaya:The long-term outcomes ofhepatitis C virus core antigen-positive Japanese renal allograft recipients, Clinical and Experimental Nephrology,
21:1113-1123, 2017.

0330B007(Ichikawa K), Konta T, Sato H, Ueda Y, Yokoyama H:The clinical and pathological characteristics of nephropathies
in connective tissue diseases in the Japan Renal Biopsy Registry (J-RBR), Clinical and Experimental Nephrology,
21:1024-1029, 2017.

Case Reports
0330D001

Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko
Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient withtuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.

Presentations at Conference
International Conference (Presentations)
0330I001

N.Hayashi, Y.Matsui, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:Clinical impact of glomerular mannosebinding lectin deposition in intrinsic antigen-related membranous nephropathy, The Annual of American Sociey ofNephrology, 2017.

- 33 -

0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Associate Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

KONISHI Kazunori

diabetes, hypertenstion, arteriosclerotic disease

Assistant Professor

WATANABE Ai

diabetes

Assistant Professor

NITTA Kyouko

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Books
0340A001

Daisuke Koya:Capter3 Patient assessment and diagnosis, Managing diabetic nephropathies in clinical practice, 4756, Adis, Cham, 2017.

Publications
Originals
0340B001(Yasuhiro Onogi), Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura,
Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara, Toshiyasu
Sasaoka:PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in DietInduced Obesity, Diabetes, 66:4;1008-1021, 2017.

- 34 -

0340B002(Shigehiro Katayama), Daishiro Yamada, Mikihiro Nakayama, Takashi Yamada, Masafumi Myoishi, Masaharu Kato,
Christina Nowack, Peter Kolkhof, Yoshimitsu Yamasaki, on behalf of the ARTS-DN Japan Study Group:A
randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus anddiabetic nephropathy, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 31:4;758-765, 2017.

0340B003

Hiroki Ito, Atsushi Nakagawa, Daisuke Koya:Reduced incretin effect in type 2 diabetes is mainly attributable toimpaired glucose responsiveness of β-cells: evaluation via an oral sugar load under a hyperglycemic clamp, Journalof Kanazawa Medical University, 42:1;7-16, 2017.

0340B004

Norikazu Ueki, Keizo Kanasaki, Megumi Kanasaki, Satoru Takeda, Daisuke Koya:Catechol-O-Methyltransferase
Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II, Hypertension, 69:6;11561164, 2017.

0340B005

Munehiro Kitada, Shin-ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto
Nishizawa, Atsushi Nakagawa, Daisuke Koya:Anagliptin ameliorates albuminuria and urinary liver-type fatty acidbinding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent
manner, BMJ open diabetes research & care, 5:1;e000391, 2017.

0340B006

Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno,
Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of Nacetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.

0340B007

Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu
Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya:Deficiency in catechol-omethyltransferase is linked to a disruption of glucose homeostasis in mice, SCIENTIFIC REPORTS, 7:1;7927,
2017.

0340B008

Munehiro Kitada, Yoshio Ogura, Hiroko Maruki-Uchida, Masahiko Sai, Taeko Suzuki, Keizo Kanasaki, Yuna Hara,
Hiromi Seto, Yuka Kuroshima, Itaru Monno, Daisuke Koya:The Effect of Piceatannol from Passion Fruit (Passiflora
edulis) Seeds on Metabolic Health in Humans, NUTRIENTS, 9:10;1142, 2017.

0340B009(Per-Henrik Groop), Mark E Cooper, Vlado Perkovic, Berthold Hocher, Keizo Kanasaki, Masakazu Haneda,
Guntram Schernthaner, Kumar Sharma, Robert C Stanton, Robert Toto, Jessica Cescutti, Maud Gordat, Thomas
Meinicke, Audrey Koitka-Weber, Sandra Thiemann, Maximilian von Eynatten:Linagliptin and its effects on
hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINAT2D trial, DIABETES OBESITY & METABOLISM, 19:11;1610-1619, 2017.

0340B010

Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monnno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya:Cyclic
and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar
fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity, NEPHROLOGY, 22:12;1030-1034, 2017.

0340B011(Tsutomu Wada), Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro
Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi
Tsuneki, Toshiyasu Sasaoka:Eplerenone prevented obesity-induced inflammasome activation and glucose
intolerance, JOURNAL OF ENDOCRINOLOGY, 235:3;179-191, 2017.

Reviews
0340C001

Yuta Takagaki, Daisuke Koya, Keizo Kanasaki:Dipeptidyl peptidase-4 inhibition and renoprotection: the role ofantifibrotic effects, CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 26:1;56-66, 2017.

0340C002

Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya:Regulating Autophagy as a Therapeutic Target for
Diabetic Nephropathy, Current diabetes reports, 17:7;53, 2017.

0340C003

Keizo Kanasaki:DKD in elderly population, 75:11;1724-1732, 2017.

Short Communications
0340E001

Daisuke Koya:Impact of empagliflozin on diabetic kidney disease, JOURNAL OF DIABETES INVESTIGATION,
8:5;658-660, 2017.

- 35 -

Presentations at Conference
International Conference (Key Note Lecture)
0340G001

Daisuke Koya:Luseogliflozin in T2DM manegement, Diabetes Asia 2017, Kuala Lumpur, 2017.

International Conference (Symposium)
0340H001

Yuta Takagaki, Keizo Kanasaki, Makoto Kato, Daisuke Koya:Dipeptidyl peptidase-4 plays a pathogenic role in
BSA-induced kidney injury in diabetic mice, 2017 Asia Islet Biology & Incretin Symposium (AASD AffiliatedSymposium), Seoul, 2017.03.

0340H002

Keizo Kanasaki:Symposium II The pathological role of endothelial DPP-4 in diabetic kidney fibrosis, 2017 Asia Islet
Biology & Incretin Symposium (AASD Affiliated Symposium), Seoul, 2017.03.

0340H003

Daisuke Koya:Symposium 1 Autophagy & diabetes Autophagy protects against kidney injury related to aging,obesity and diabetes, 3rd Korea-Japan Diabetes Forum in conjunction with 30th Spring Congress of Korean
Diabetes Association, Busan, 2017.05.

0340H004

Daisuke Koya:Nutrition, inflammation & metabolism Beneficial effects of calorie restriction and protein dilution,
The 37th Annual Meeting of the Korean Society of Nephrology (KSN2017), Seoul, 2017.05.

0340H005

Daisuke Koya:Experience in diabetes management across countries A truly Asian real world evidence of SGLT2i,
Diabetes Asia 2017, Kuala Lumpur, 2017.10.

International Conference (Presentations)
0340I001

Y.Takagaki, S.M.Lee, D.Zha, K.Kanasaki, D.Koya:Atg5 deficiency in endothelial cells contributes to thedevelopment of IL-6 dependent endothelial to mesenchymal transition and kidney fibrosis, 53rd Annual Meeting of
the European Association for the Study of Diabetes (EASD 2017), Lisbon, 2017.

0340I002

O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada, A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya,
M.Nakada,H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of
Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th
Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.

- 36 -

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Professor

KAWABATA Hiroshi

Hematology, Iron metabolizm

Associate Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Senior Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Senior Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

FUJIMOTO Shino

Hematology and Immunology

Assistant Professor

HASHIZUME Chieko

Hematology and Immunology

Assistant Professor

NAGAYA Shingo

Hematology and Immunology

Keywords of Research
Sjogren's syndrome, malignant lymphoma, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, rheumatoid
arthritis, systemic lupus erythematosus, TAFRO syndrome, Cattleman's disease, IgG4-related disease, proteomics, leptin,
follicular dendritic cell,regeneration therapy

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
1, Clinico-pathological study of a new disease entity; TAFRO syndrome.
2, Pathophysiological analysis of IgG4-related disease.
(1) Evaluation of CD14+cells in lymphoid follicle.
(2) Proteomics analysis.
(3) Lipid mediators and those balance .
3, Analysis of Leptin in patients with systemic autoimmune disorders.
4, Evaluation and regeneration therapy of salivary gland tissue in Sjogren's syndrome.
5, Clinical study for patients with intractable aggressive lymphomas.
6, Analysis of iron metabolism in hematological disorders.

Publications
Originals
0350B001(Takaya Komori), Toshiaki Kogame, Takashi Nomura, Yo Kaku, Yuichiro Endo, Chiyuki Ueshima, Masahiro Hirata,
Tatsuki R.Kataoka, Hiroshi Kawabata, Kenji Kabashima:Maculopapular rash during a nadir period in a patient withacute myeloid leukaemia, European Journal of Dermatology, 27:3;316-317, 2017.

0350B002(S.Sakamoto), H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi,
A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.

- 37 -

0350B003

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

0350B004(Katsuhiro Miura), Jun Konishi, Takaaki Miyake, Masanori Makita, Atsuko Hojo, Yasufumi Masaki, Masatoshi Uno,
Jun Ozaki, Chikamasa Yoshida, Daigo Niiya, Koichi Kitazume, Yoshinobu Maeda, Jun Takizawa, Rika Sakai,
Tomofumi Yano, Kazuhiko Yamamoto, Kazutaka Sunami, Yasushi Hiramatsu, Kazutoshi Aoyama, Hideki Tsujimura,
Jun Murakami, Yoshihiro Hatta, Masatoshi Kanno:A host-dependent prognostic model for elderly patients withdiffuse large B-cell lymphoma, The Oncologist, 22:5;554-560, 2017.

0350B005

Hiroshi Kawabata, Kaoru Tohyama, Akira Matsuda, Kayano Araseki, Tomoko Hata, Takahiro Suzuki, Hidekazu
Kayano, Kei Shimbo, Yuji Zaike, Kensuke Usuki, Shigeru Chiba, Takayuki Ishikawa, Nobuyoshi Arima, Masaharu
Nogawa, Akiko Ohta, Yasushi Miyazaki, Kinuko Mitani, Keiya Ozawa, Shunya Arai, Mineo Kurokawa, Akifumi
Takaori-Kondo, The Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes:
Validation of the revised international prognostic scoring system in patients with myelodysplastic syndrome inJapan: results from a prospective multicenter registry, International journal of hematology, 106:375-384, 2017.

0350B006(Yoshinobu Maeda), Hisakazu Nishimori, Isao Yoshida, Hasushi Hiramatsu, Masatosh Uno, Yasufumi Masaki,
Kazutaka Sunami, Taro Masunari, Yuichiro Nawa, Hiromichi Yamane, Hiroshi Gomyo, Tsutomu Takahashi,
Tomofumi Yano, Keitaro Matsuo, Koichi Ohshima, Shigeo Nakamura, Tadashi Yoshino, Mitsune Tanimoto:
Dose-abjusted EPOCH chemotherapy for untreated peripheral T-cell lymphomas: a multicenter phase Ⅱ trial ofWest-JHOG PTCL0707, Haematologica, 102:12;2097-2103, 2017.

0350B007

Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi
Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.

Reviews
0350C001(Junithci Kitazawa), Yoshiko Tamai, Hiroshi Fujita, Shigeyoshi Makino, Yasufumi Masaki, Eijiro Omoto, HidetakaOda, Hiroshi Nakamura, Toshihiko Futagi, Yuu Kuroda, Naoki Tachibana, Masanori Matsumoto, Tadashi
Matsushita:Red cell transfusion in home, Japanese Journal of Transfusion and Cell Therapy, 63:5;664-773, 2017.

0350C002(Tomohiro Koga), Shino Fujimoto, Astushi Kawakami, Hiroshi Kawabata, Yasufumi Masaki, Tadamitsu Kishimoto
Kazuyuki Yoshizaki:Therapeutic outlook for Castleman's disease: prospects for the next decade, EXPERTOPINION ON ORPHAN DRUGS, 5:8;633-640, 2017.

0350C003

Yoshimasa Fujita:Leptin and autoimmune disease, Japanese Journal of Clinical Immunology, 40:3;155-159, 2017.

0350C004

Yasufumi Masaki, Shino Fujimoto, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami, Yopshimasa
Fujita, Hiroshi Kawabata, Toshihiro Fukushima:The treatment strategy of IgG4-related disease - from the result ofprospective clinical study -, 29:2;140-146, 2017.

0350C005

Hiroshi Kawabata:Progress in iron metabolism research, Rinsho Ketsueki, 58:10;1864-1871, 2017.

Case Reports
0350D001

Shino Fujimoto, Hiroshi Kawabata, Nozomu Kurose, Haruka Kawanami-Iwao, Tomoyuki Sakai, Takafumi Kawanami,
Yoshimasa Fujita, Toshihiro Fukushima, Yasufumi Masaki: Sjögren's syndrome manifesting as clinicopathologicalfeatures of TAFRO syndrome, Medicine, 96;e9220,2017.

0350D002(Toshimitsu Ueki), Masaru Nasu, Hiroko Kaiume, Yuki Hiroshima, Masahiko Sumi, Masahide Watanabe, Dai Inoue,
Yasufumi Masaki, Yasuharu Sato, Masaru Kojima, Hikaru Kobayashi:Multicentric Castleman's disease with multiple
hepatic mass lesions mimicking malignant liver tumors, Rinsho Ketsueki, 58:6;630-636, 2017.

Short Communications
0350E001

Hiroshi Kawabata:Overview, Rinsho Ketsueki, 58:4;327-328, 2017.

- 38 -

Others
0350F001(Yataro Yoshida), Tatsuya Katsurada, Yukiharu Nakabou, Hiroshi Kawabata:Efficacy of interferon-alpha in essential
thrombocythemia during pregnancy, Annals of Hematology, 96:877-878, 2017.

Presentations at Conference
International Conference (Key Note Lecture)
0350G001

Toshiro Okazaki:Inhibition of acute colitis and hepatic infiltration malignant cells by SMS2 deficiency, Key notespeaker at 8th international Ceramide Conference, New York, 2017.05.

0350G002

Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2)
in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.

0350G003

Toshiro Okazaki:Ceramid increase by deficiency of sphingomyelin synthase (SMS) 2 suppressed murine acute colitis
and colon cancer initiation through cytokine/chemokine inhibition, Bioactive Lipids in Cancer,Inflammation&Related Diseases, 15th international conference, Puerto Vallarta, Mexico, 2017.10.

- 39 -

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Associate Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Associate Professor

SANADA Mitsuru

Clinical neurology, Neurophysiology

Senior Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

FUJITA Michiyo

Clinical neurology

Assistant Professor

OONO Miki

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis,

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(Shigeaki Suzuki), Nobuhisa Ishikawa, Fumie Konoeda, Nobuhiko Seki, Satoshi Fukushima, Kikuko Takahashi,
Hisashi Uhara, Yoshikazu Hasegawa, Shinichiro Inomata, Yasushi Otani, Kenji Yokota, Takashi Hirose, Ryo
Tanaka, Norihiro Suzuki, Makoto Matsui:Nivolumab-related myasthenia gravis with myositis and myocarditis inJapan, Neurology, 89:1127-1134, 2017.

0360B002(Yuko Yamagishi), Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro
Chiba, Ryuji Kaji, Takashi Kanda, Kenishi Kaida, Shu-ichi Ikeda, Tatsuro Mutoh, Ryo Yamazaki, Hiroshi
Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki:Markers for Guillain-Barre
syndrome with poor prognosis:a multi-center stydy, Journal of the Peripheral Nervous System, 22:433-439, 2017.

0360B003(Masaaki Niino), Toshiyuki Fukazawa, Jun-ichi Kira, Tatsusada Okuno, Masahiro Mori, Nobuo Sanjyo, Takashi
Ohashi, Hikoaki Fukaura, Juichi Fujimori, Yuko Shimizu, Nobuhiro Mifune, Yusei Miyazaki, Eri Takahashi, Seiji
Kikuchi, Dawn Langdon, RaIph HB Benedict, Makoto Matsui:Validation of the Brief International Cognitive
Assessment for Multiple Selerosis in Japan, Multiple Sclerosis Journal Experimental ,Translational Clinical,
3:4;2055217317748972, 2017.

Reviews
0360C001

Makoto Matsui:How to use the new 2017 Japanese guidelines for multiple sclerosis and neuromyelitis optica,
Clinical and Experimental Neuroimmunology, 8:351-360, 2017.

0360C002

Mitsuru Sanada:Vascular endothelial function test, The Autonomic Nervous System, 54:234-237, 2017.

- 40 -

Case Reports
0360D001

Megumi Nakanishi, Nobuaki Uchida, Ukichiro Kawai, Miki Oono, Michiyo Fujita-Nakata, Mitsuru Sanada, Shigemi
Nagayama, Makoto Matsui:A case of Mumps Virus Reinfection Manifesting as Severe Meningitis that Mimicked
Tuberculous Meningitis, Journal of Neuroinfectious Diseases, 8:2, 2017.

- 41 -

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Professor

YASUMOTO Kazuo

Gastric cancer, Cancerous peritonitis molecular target therapy

Senior Assistant Professor

HISAMURA Kazuho

Social Work, Social Welfare, Psycho-Oncology

Assistant Professor

KASAI Suguru

Medical Oncology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology,

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0363B001

Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo,
Katsuhito Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.

0363B002(Keiko Yukawa), Hirono Ishikawa, Yoshihiko Yamazaki, Jimpei Misawa, Kiichiro Tsutani, Ichiro Arai, Yoshiharu
Motoo, Takahiro Kiuchi:Economic burden and mental distress in using complementary and alternative medicine,and formal supports by medical professional of japanese patients with chronic diseases, Japanese Pharmacology &Therapeutics, 45:3;345-355, 2017.

0363B003

Y Motoo, T Hakamatsuka, N Kawahara, I AraiI, K Tsutani:Standards of reporting Kampo products (STORK) in
research articles, Journal of Integrative Medicine, 15:3;182-185, 2017.

0363B004(Suzuki Toshiaki), Yamamoto Ayano, Ohsawa Masahiro, Motoo Yoshiharu, Mizukami Hajime, Makino Toshiaki:
Effect of ninjin'yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice, Journal of Natural
Medicines, 71:4;757-764, 2017.

0363B005

Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, MichikoMichibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of thepredictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.

0363B006(Kita Kenji), Arai Sachiko, Nishiyama Akihiro, Taniguchi Hirokazu, Fukuda Koji, Wang Rong, Yamada Tadaaki,
Takeuchi Shinji, Tange Shoichiro, Tajima Atsushi, Nakada Mitsutoshi, Yasumoto Kazuo, Motoo Yoshiharu,
Murakami Takashi, Yano Seiji:In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy oftargeted drugs, Cancer Medicine, 6:12;2972-2983, 2017.

- 42 -

Reviews
0363C001

Yoshiharu Motoo:Gastrointestinal adverse effects and their management in molecular targeting therapy, Nippon
Rinsho, 75:9;1425-1429, 2017.

Case Reports
0363D001

Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi
Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due tocombination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer andChemotherapy, 44:12;1373-1375, 2017.

Presentations at Conference
International Conference (Symposium)
0363H001

Y Motoo:Standards of Reporting Kampo Products (STORK) in research articles., The 4th International Symposiumof Japanese Kampo Medicine (ISJKM), Berlin, 2017.05.

0363H002

Y Motoo:Chemotherapy Support Team (CST) and Kampo, 12th International Congress of Complementary Medicine
and Research (ICCMR), Berlin, 2017.05.

International Conference (Presentations)
0363I001

K Yasumoto, A Kawashima:The characteristics of cancer stroma in the development of scirrhous gastric cancer,
The 5th Annual Meeting of the International Cytokine & Interferon Society "Cytokine 2017", Kanazawa, 2017.10.

- 43 -

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

KAWAI Yasuhiro

Clinical Infectious Diseases, Infection Control and Prevention

Assistant Professor

USUDA Daisuke

Clinical Infectious Diseases, Infection Control and Prevention

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs,

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001

Noda Yoko, Iinuma Yoshitsugu, Usuda Daisuke, Taga Mitsutoshi, Shinmachi Miyuki, Maeda Kazumi, Maeno
Toshiko:Revising the Hygiene Maintenance of Urine Disposal Facilitated the Appropriate Indication of Urine
Collection, Japanese Journal of Environmental Infections, 32:1;23-28, 2017.

0366B002

Aya Hashimoto, Yoshi Tanaka, Masami Matsumoto, Katsuhiro Nagata, Shizuyo Nakagawa, Yoshitame Yanaida,
Yoshitsugu Iinuma:Evaluation of fully automated urine particle analyzer sysmex UF-5000, Japanese Journal of
Medical Technology, 66:3;255-265, 2017.

0366B003

Kawamura Kae, Iinuma Yoshitsugu, Usuda Daisuke, Hashimoto Aya, Matsumoto Masami, Tanaka Yoshi:Evaluationof automated urine particle analyzer, UF-5000, as a screening tool to identify Gram stainability of urinal
pathogens, Japanese Journal of Medical Technology, 66:5;516-523, 2017.

0366B004

Y.Tanaka, M.Matsumoto, M.Yasui, R.Hokama, H.Takehara, Y.Itose, Y.Iinuma:Performance Evaluation of the SemiAutomated Urine Chemistry Analyzer UC-1000, Sysmex Journal International, 27:1, 2017.

Reviews
0366C001

Yoshitsugu Iinuma:Infection prevention medical fees and microbiology laboratory, 63:10;255-261, 2017.

Case Reports
0366D001

Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri
without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.

0366D002

A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated byrenal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.

0366D003

Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.

- 44 -

Others
0366F001

Yoshitsugu Iinuma:Occupational Health Program in Clinical Laboratory, Rinsho Byori, 65:4;419-423, 2017.

0366F002

Yoshitsugu Iinuma:Practical Use of Biomarkers for Supporting Diagnosis and Treatment of Infectious Diseases,
Rinsho Byori, 65:4;419-423, 2017.

- 45 -

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Professor

FURUTA Hisakazu

Sleep-wake disorders

Associate Professor

AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology

Associate Professor

UENISHI Hiroaki

Cardiovascular Medicine

Associate Professor(Additional Post)

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Assistant Professor

YAMASAKI Naruhiro

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0368B001(Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of
tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.

0368B002(Nobuyoshi Ishiyama), Kouji Sakamaki, Younosuke Shimomura, Kazuhiko Kotani, Kokoro Tsuzaki, Naoki Sakane,
Kazuya Miyashita, Isao Fukamachi, Junji Kobayasi, Kimber L Stanhope, Peter J Havel, Keiko Kamachi, Akira
Tanaka, Yoshiharu Tokita, Tethuo Machida, Masami Murakami, Katsuyuki Nakajima:Lipoprotein lipase dose notincrease significantly in the postprandisl plasma, Clinica Chimica Acta, 464:204-210, 2017.

0368B003(Hayato Tada), Masaaki Kawashiri, Atsushi Nohara, Akihiro Inazu, Junji Kobayasi, Kenji Yasuda, Hiroshi Mabuchi,
Masakazu Yamagishi, Kenshi Hayashi:Lipid Management in a Japanese Community:Attainment Rete of Target Set
by the Japan Atherosclerosis Society Guidelines for the Prevention of Atherosclerotic Cardiovascular Diseases
2012, Journal of atherosclerosis and thrombosis, 24:338-345, 2017.

0368B004(Kazuya Miyashita), Katsuyuki Nakajima, Isamu Fukamachi, Yuji Murada, Takafumi Koga, Yohnosuke Shimomura,
Tetsuyo Machida, Masami Murakami, Junji Kobayasi:A new enzyme-linked immunosorbent assay system for humanserum hepatic triglyceride lipase, JOURNAL OF LIPID RESEARCH, 58:1591-1597, 2017.

0368B005

Hirokazu Kakuda, Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.

- 46 -

Reviews
0368C001(Katsuyuki Nakajima), Yoshiharu Tokita, Koji Sakamaki, Younosuke Shimomura, Junji Kobayasi, Keiko Kamachi,
Akira Tanaka, Kimber L Stanhope, Peter J Havel, Tao Wang, Tetsuo Machida, Masami Murakami:Triglyceride
content in remnant lipoproteins is significantiy increased after food intake and is associated with plasma lipoprotein
lipase, Clinica Chimica Acta, 23:29;5364-5370, 2017.

Presentations at Conference
International Conference (Presentations)
0368I001

Ryosuke Tsuda:Results of a soccer teaching program intended to help students improve and acquire knowledge ofphysical fitness, The 22nd annual Congress of the European College of Sport Science (ECSS), Essen, 2017.07.

- 47 -

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Associate Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Senior Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

MORITA Takuro

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

OKUNO Tazuo

Geriatrics, Circulation

Assistant Professor

HIMENO Taro

Geriatrics, Circulation

Assistant Professor

HIGASHIKAWA
Toshihiro

Gerontology

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis,

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

Okuno Tazuo, Watanabe Keisuke, Nakajima Kumie, Iritani Osamu, Yano Hiroshi, Morita Takuro, Himeno Taroh,
Igarashi Yuta, Okuro Masashi, Morimoto Shigeto:Major electrocardiographic abnormality predicts support/careneed certification and/or death in community-dwelling older adults with no history of cardiovascular disease.,
Geriatrics & gerontology international, 17:1967-1976, 2017.

0370B002

Morita Takuro, Okuno Tazuo, Himeno Taroh, Watanabe Keisuke, Nakajima Kumie, Koizumi Yumi, Yano Hiroshi,
Iritani Osamu, Okuro Masashi, Morimoto Shigeto:Glycemic control and disability-free survival in hypoglycemic
agent-treated community-dwelling older patients with type 2 diabetes mellitus., Geriatrics & gerontology
international, 17:1858-1865, 2017.

- 48 -

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITOH Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

FUJIKI Takuma

Pediatric Nephrology

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

OGURI Masato

Pediatric cardiology.

Assistant Professor

IKENO Kanjyu

Child neurology

Assistant Professor

KITTAKA Yuko

Pediatric allergy, Pediatric endocrinology

Assistant Professor

OKAMOTO Nobuhiro Pediatric cardiology

Assistant Professor

TOKI Shin

Pediatric allergy

Assistant Professor

SHIMIZU Yo

Fetology

Assistant Professor

FUJISAWA Reiko

Pediatric hematology, Pediatric oncology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood,

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(Hideo Sasai), Yuka Aoyama, Hiroki Otsuka, Elsayed Abdelkreem, Yasuhiro Naiki, Mitsuru Kubota, Yuji Sekine,
Masatsune Itoh, Mina Nakama, Hidenori Ohnishi, Ryoji Fujiki, Osamu Ohara, Toshiyuki Fukao:Heterozygous
carriers of succinyl-CoA:3-oxoacid CoA transferase deficiency can develop severe ketoacidosis, Journal of
Inherited Metabolic Disease, 40:845-852, 2017.

- 49 -

Case Reports
0380D001

Masatsune Itoh, Yutaka Saikawa:A novel MEN1 mutation in a Japanese adolescent with multiple endocrine
neoplasia type 1, Clinical pediatric endocrinology, 26:25-28, 2017.

0380D002

Chisato Akita, Yutaka Saikawa:Gastric Gyri - Pediatric Menetrier’s Disease, The New England Journal of
Medicine, 376:8;774, 2017.

0380D003

Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji,
Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.

0380D004

Chisato Akita, Naoki Okada, Hitoshi Sato, Mondo Kuruda, Akihiro Yachie, Yutaka Saikawa:Eary biological markers
and cytokine profiles in a case of hemorrhagic shock and encephalopathy syndrome, 16:3;474-478, 2017.

Presentations at Conference
International Conference (Presentations)
0380I001

Hitoshi Sato, Atsushi Ishii, Chisato Akita, Kanju Ikeno, Yo Niida, Sawako Yamazaki, Shinichi Hirose, Hiroaki
Kakinuma, Yutaka Saikawa:A case with severe recurrent attacks of hemiplegic migraine mimicking acuteencephalopathy, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.

- 50 -

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Associate Professor

UEHARA Takashi

Neuropharmacology

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

OHI Kazutaka

Psychiatry, Genetics, Neuropsychopharmacology, BiologicalPsychiatry, Imaging

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Assistant Professor

NITTA Yusuke

Consultation liaison psychiatry

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Assistant Professor

KIHARA Hiroaki

Brain imaging,，Schizophrenia

Assistant Professor

SHIMADA Takamitsu Brain imaging,，Schizophrenia

Assistant Professor

OKUBO Hiroaki

Assistant Professor

YASUYAMA Toshiki

Faculty

Psychiatry, Neurophysiology

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging, rTMS

Outline of Research
1.Study on regional identification of brain language areas by functional MRI―application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia
8.Study on repetitive transcranial magnetic stumilation for depression

Publications
Originals
0390B001

Ohi Kazutaka, Shimada Takamitsu, Nemoto Kiyotaka, Kataoka Yuzuru, Yasuyama Toshiki, Kimura Kohei, Okubo
Hiroaki, Uehara Takashi, Kawasaki Yasuhiro:Cognitive clustering in schizophrenia patients, their first-degree
relatives and healthy subjects is associated with anterior cingulate cortex volume, NeuroImage. Clinical, 16:248256, 2017.

0390B002

K.Ohi, T.Shimada, Ｔ.Yasuyama, H.Kihara, T.Uehara, Y.Kawasaki:Variability of 128 schizophrenia-associated genevariants across distinct ethnic populations, Translational Psychiatry, 7:1-6, 2017.

- 51 -

0390B003

T.Yasuyama, K.Ohi, T.Shimada, T.Uehara, Y.Kawasaki:Differences in social functioning among patients with major
psychiatric disorders: Interpersonal communication is impaired in patients with schizophrenia and correlates withan increase in schizotypal traits., Psychiatry research, 249:30-34, 2017.

0390B004

Y.Ryo, M.Takeuchi, N.Ueda, K.Ohi, H.Kihara, T.Shimada, T.Uehara, Y.Kawasaki:Olfactory function inneuropsychiatric disorders, PSYCHIATRY RESEARCH, 252:175-179, 2017.

0390B005

K.Ohi, T.Shimada, H.Kihara, T.Yasuyama, K.Sawai, Y.Matsuda, K,Oshima, H.Okubo, Y.Nitta, T.Uehara,
Y.Kawasaki:Impact of Familial Loading on Prefrontal Activation in Major Psychiatric Disorders: A Near-Infrared
Spectroscopy (NIRS) Study, Scientific Reports, 7:44268, 2017.

0390B006(T.Omi), H.Ito, K.Riku, K.Kanai, H.Takada, S.Fujimi, H.Matsunaga, K.Ohi:Possible factors influencing theduration of hospital stay in patients with psychiatric disorders attempting suicide by jumping, BMC Psychiatry,
17:1;99, 2017.

0390B007

Ohi Kazutaka, Shimada Takamitsu, Yasuyama Toshiki, Kimura Kohei, Uehara Takashi, Kawasaki Yasuhiro:Spatial
and temporal expression patterns of genes around nine neuroticism-associated loci, PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 77:164-171, 2017.

0390B008

Naoki Hashimoto, Yoichi M. Ito, Naohiro Okada, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Noriko
Kudo, Ariyoshi Takemura, Shuraku Son, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Asuka Katsuki,
Kazutaka Ohi, Fumio Yamashita, Shinsuke Koike, Tsutomu Takahashi, Kiyotaka Nemoto, Masaki Fukunaga,
Toshiaki Onitsuka, Yoshiyuki Watanabe, Hidenori Yamasue, Michio Suzuki, Kiyoto Kasai, Ichiro Kusumi, Ryota
Hashimoto, for COCORO:The effect of duration of illness and antipsychotics on subcortical volumes inschizophrenia: Analysis of 778 subjects, NeuroImage. Clinical., 17:563-569, 2017.

0390B009

Ohi Kazutaka, Sumiyoshi Chika, Fujino Haruo, Yasuda Yuka, Yamamori Hidenaga, Fujimoto Michiko, Sumiyoshi
Tomiki, Hashimoto Ryota:A Brief Assessment of intelligence Decline in Schizophrenia As Represented by the
Difference between Current and Premorbid intellectual Quotient, FRONTIERS IN PSYCHIATRY, 8:293, 2017.

Case Reports
0390D001

Masao Ogawa, Michiko Michibuchi, Takanori Wagatsuma, Mikako Nishikawa, Yasuhiro Kawasaki, Hideaki
Tsuchida, Kanako Teraguchi:A Case Whose Delirium Improved with Discontinuation of Continuous Deep Sedation
Initiated for Refractory Delirium at the End Stage of Cancer, Palliative Care Research, 12:1;501-505, 2017.

0390D002

Ohi Kazutaka, Kuwata Aki, Shimada Takamitsu, Yasuyama Toshiki, Nitta Yusuke, Uehara Takashi, Kawasaki
Yasuhiro:Response to benzodiazepines and the clinical course in malignant catatonia associated with schizophrenia:
A case report., Medicine, 96:16;e6566, 2017.

Presentations at Conference
International Conference (Presentations)
0390I001

K.Ohi, T.Shimada, T.Yasuyama, T.Uehara, Y.Kawasaki:Variability of 128 Schizophrenia-Associated Gene Variants
across Distinct Ethnic Populations, 5thAsian College of Neuropsychopharmacology 2017, Bali, 2017.04.

0390I002

T.Shimada:Differences in social functioning among patients with major psychiatric disorders: Interpersonalcommunication is impaired in patients with schizophrenia and correlates with an increase in schizotypal traits,
5thAsian College of Neuropsychopharmacology 2017, Bali, 2017.04.

0390I003

T.Shimada, K.Ohi, T.Yasuyama, T.Uehara, Y.Kawasaki:Differences in social functioning among patients with major
psychiatric disorders: Interpersonal communication is impaired in patients with schizophrenia and correlates withan increase in schizotypal traits, 13th World Congress of Biological Psychiatry, Copenhagen, 2017.06.

0390I004

K.Ohi, T.Shimada, T.Yasuyama, K.Sawai, K.Oshima, H.Okubo, Y.Nitta, T.Uehara, Y.Kawasaki:Impact of familialloading on prefrontal activation in major psychiatric disorders: A Near-Infrared Spectroscopy (NIRS) study , 13th
World Congress of Biological Psychiatry, Copenhagen, 2017.06.

0390I005

K.Ohi, T.Shimada, T.Yasuyama, T.Uehara, Y,Kawasaki:Variability of 128 Schizophrenia-Associated Gene Variants
across Distinct Ethnic Populations., 13th World Congress of Biological Psychiatry, copenhagen, 2017.06.

- 52 -

0390I006

Y. Kawasaki, K. Ohi, T. Shimada, T. Uehara, Y. Nitta, H. Kihara, H. Okubo:Investigation of disturbed functional
connectivity related to mental disorders using independent component analysis., International Conference on Basicand Clinical Multimodal Imaging, Bern, 2017.08.

- 53 -

0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging、Radiation therapy

Professor

WATANABE Naoto

Nuclear Medicine

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Senior Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Senior Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

OTA Kiyotaka

Radiation Therapy，Nuclear Medicine

Assistant Professor

KONDO Tamaki

Diagnostic Imaging

Assistant Professor

TSUCHIYA Naoko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

OISO Kazumasa

Diagnostic Imaging

Assistant Professor

NAKAJIMA Kento

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjogren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium,

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo,
Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patientswith idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.

0400B002

Masataka Kitadate, Ichiro Toyota, Munetaka Matoba, Hisao Tonami:"Gun grip"Central venous puncture method,
Journal of Kanazawa Medical University, 42:1-6, 2017.

0400B003

Tsuchiya Naoko, Doai Mariko, Usuda Katsuo, Uramoto Hidetaka, Tonami Hisao:Non-small cell lung cancer:
Whole-lesion histogram analysis of the apparent diffusion coefficient for assessment of tumor grade, lymphovascularinvasion and pleural invasion., PloS one, 12:2;e0172433, 2017.

0400B004(Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki , Yuka Nakamura, Manabu Oguchi,
Tsutomu Takegami, Naoto Watanabe.:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.

- 54 -

0400B005

Usuda Katsuo, Funazaki Aika, Maeda Ryo, Sekimura Atsushi, Motono Nozomu, Matoba Munetaka, Uramoto
Hidetaka:Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging forPrimary Lung Cancer, Annals of Thoracic and Cardiovascular Surgery, 23:6;275-280, 2017.

0400B006

Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of
18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients.,
Breast cancer, 24:1;121-127, 2017.

0400B007

Matoba Munetaka, Tuji Hiroyuki, Shimode Yuzo, Kondo Tamaki, Oota Kiyotaka, Tonami Hisao:The role ofchanges in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients withhead and neck squamous cell carcinoma treated with chemoradiotherapy: preliminary findings, BRITISH JOURNAL
OF RADIOLOGY, 90:20150404, 2017.

Reviews
0400C001

Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi
Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging(DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.

Presentations at Conference
International Conference (Presentations)
0400I001

Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa:
Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after
upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.

0400I002

Katsuo Usuda, Nozomu Motono, Makoto Tanaka, Yuichiro Machida, Takuma Matsui, Munetaka Matoba, Hidetaka
Uramoto:Diagnostic performance of diffusion weighted imaging for multiple hilar and mediastinal lymph nodes FDG
accumulation, BIT's 10th Annual World CANCER Congress-2017, Barcelona, 2017.05.

0400I003

H.Nagata, M.Matoba, M.Doai, T.Takahashi, Y.Ishida, M.Kawashima, H.Tonami:New Method for Diagnosing
Metastatic Cervical Lymph Nodes With Head And Neck Squamous Cell Carcinoma Using Third-Generation DualEnergy CT, The 103nd Scientific Assembly & Annual Meeting of the Radiological Society of North America Annual
Meeting, Chicago, 2017.11.

0400I004

M.Doai, N.Tsuchiya, H.Tonami, K.Usuda, H.Uramoto, M.Matoba:Whole-lesion evaluation of lung adenocarcinoma
for predicting pathological grade:Comparative study between histogram Parameters of ADC on DWI,and MTV aswell as TLG on 18F-FDG PET/CT, The 103nd Scientific Assembly & Annual Meeting of the Radiological Societyof North America Annual Meeting, Chicago, 2017.11.

- 55 -

0412

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

SHIKATA Hiroo

Vascular Surgery

Associate Professor

NAGAYOSHI Yasuhiro Cardiovascular Surgery

Associate Professor

ISHIMARU KazuhikoPedeatric Cardiovascular Surgery

Senior Assistant Professor

NOGUCHI Yasuhisa

Vascular Surgery

Assistant Professor

ARAKI Kanta

Pediatric Cardiovascular Surgery

Assistant Professor

SAKAMOTO Daisuke Cardiovascular Surgery

Assistant Professor

TANAKA Hirokazu

Assistant Professor

TSUCHIYA Hirokazu Vascular Surgery

Cardiovascular Surgery

Keywords of Researchcardiovascular Surgery, Ischemic Heart Surgery, Valuvlar heart Surgery, ASO, TAO, TEVAR, EVAR, Left and Right
ventricular assist system (L & R VAS), Cardiac surgery for severe heart failure, Raser surgery, CABG, OPCAB, Dor'S
operation, IABP , PCPS, Batista's operation, Pacemaker implantation, Adult cardiac surgery, Pediatric cardiac srugery- 56 -

0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

URAMOTO Hidetaka Thoracic Surgery,Video assisted thoracoscopic surgery,Lung Cancer

Professor

USUDA Katsuo

thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MATSUI Takuma

thoracic surgery, lung cancer

Assistant Professor

SEKIMURA Atsushi

thoracic surgery, lung cancer

Assistant Professor

MAEDA Ryothoracic surgery, lung cancer

Assistant Professor

FUNASAKI Aika

thoracic surgery, lung cancer

Faculty

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy- 57 -

Publications
Originals
0415B001

Tsuchiya Naoko, Doai Mariko, Usuda Katsuo, Uramoto Hidetaka, Tonami Hisao:Non-small cell lung cancer:
Whole-lesion histogram analysis of the apparent diffusion coefficient for assessment of tumor grade, lymphovascularinvasion and pleural invasion., PloS one, 12:2;e0172433, 2017.

0415B002

Usuda Katsuo, Funazaki Aika;, Maeda Ryo, Sekimura Atsushi, Motono Nozomu, Matoba Munetaka, Uramoto
Hidetaka:Economic Benefits and Diagnostic Quality of Diffusion-Weighted Magnetic Resonance Imaging forPrimary Lung Cancer, Annals of Thoracic and Cardiovascular Surgery, 23:6;275-280, 2017.

0415B003(Hajime Kikuchi), Jun Sakakibara-Konishi, Megumi Furuta, Hiroshi Yokouchi, Hiroshi Nishihara, Shigeo Yamazaki,
Shigeo Yamazaki, Hidetaka Uramoto, Fumihiro Tanaka, Masao Harada, Kenji Akie, Fumiko Sugaya, Yuka Fujita,
Kei Takamura, Tetsuya Kojima, Toshiyuki Harada, Mitsunori Higuchi, Osamu Honjo, Yoshinori Minami, Naomi
Watanabe, Satoshi Oizumi, Hiroyuki Suzuki, Takashi Ishida, Hirotoshi Dosaka-Akita, Hiroshi Isobe, Mitsuru
Munakata, Masaharu Nishimura:Expression of notch1 and numb in small cell lung cancer, Oncotarget, 2:1-11,
2017.

0415B004

Yuki Nakajima, Yoshihito Iijima, Hiroyasu Kinoshita, Hirohiko Akiyama, Takeshi Beppu, Hidetaka Uramoto,
Tomomi Hirata:Surgical Treatment for Pulmonary Metastasis of Head and Neck Cancer: Study of 58 Cases., Annalsof thoracic and cardiovascular surgery, 23:4;169-174, 2017.

0415B005(Gemmill Robert M), Nasarre Patrick, Nair-Menon Joyce, Cappuzzo Federico, Landi Lorenza, D'Incecco Armida,
Uramoto Hidetaka, Yoshida Takeshi, Haura Eric B, Armeson Kent, Drabkin Harry A:The neuropilin 2 isoform
NRP2b uniquely supports TGF beta-mediated progression in lung cancer, Science signaling, 10:462;1-11, 2017.

0415B006

Motono Nozomu, Matsui Takuma, Machida Yuichiro, Usuda Katsuo, Uramoto Hidetaka:Prognostic significance ofhistologic subtype in pStage I lung adenocarcinoma., Medical oncology, 34:6;2-6, 2017.

0415B007

Yamamoto Gou, Kikuchi Mari, Kobayashi Shiho, Arai Yoshiko, Fujiyoshi Kenji, Wakatsuki Tomokazu, Kakuta
Miho, Yamane Yuki, Iijima Yoshihito, Mizutani Hideaki, Nakajima Yuki, Sudo Junko, Kinoshita Hiroyasu, Kurimoto
Futoshi, Akiyama Hirohiko, Uramoto Hidetaka, Sakai Hiroshi, Akagi Yoshito, Akagi Kiwamu:Routine genetic
testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation
sequencing, INTERNATIONAL JOURNAL OF ONCOLOGY, 50:5;1579-1589, 2017.

0415B008

Usuda Katsuo, Maeda Sumiko, Motomo Nozomu, Tanaka Makoto, Ueno Masakatsu, Machida Yuichiro, Sagawa
Motoyasu, Uramoto Hidetaka:Pulmonary Function After Lobectomy: Video-Assisted Thoracoscopic Surgery
Versus Muscle-Sparing Mini-thoracotomy, INDIAN JOURNAL OF SURGERY, 79:6;504-509, 2017.

0415B009

Matsumura Yuki, Suzuki Hiroyuki, Ohira Tetsuya, Shiono Satoshi, Abe Jiro, Sagawa Motoyasu, Sakurada Akira,Katahira Masato, Machida Yuichiro, Takahashi Satomi, Okada Yoshinori:Matched-pair analysis of a multiinstitutional cohort reveals that epidermal growth factor receptor mutation is not a risk factor for postoperative
recurrence of lung adenocarcinoma., Lung cancer, 114:23-30, 2017.

Reviews
0415C001

Katsuo Usuda, Takuma Matsui, Nozomu Motono, Yuichiro Machida, Munetaka Matoba, Hisao Tonami, Yoshimichi
Ueda, Hidetaka Uramoto:Diagnostic benefits and prospects of diffusion-weighted magnetic resonance imaging(DWI) for thoracic tumor, The Journal of the Japanese Association for Chest Surgery, 6:5;305-311, 2017.

Case Reports
0415D001

Machida Yuichiro, Motono Nozomu, Matsui Takuma, Usuda Katsuo, Uramoto Hidetaka:Successful endovascularcoil embolization in an elder and asymptomatic case of anomalous systemic arterial supply to the normal basal
segment, International journal of surgery case reports, 34:103-105, 2017.

0415D002(Iijima Yoshihito), Kinoshita Hiroyasu, Nakajima Yuki, Akiyama Hirohiko, Uramoto Hidetaka, Hirata Tomomi,
Isolated solitary lung metastasis 12 years after radical prostatectomy for prostate cancer without elevation of theserum prostate-specific antigen level, The Journal of the Japanese Association for Chest Surgery, 31:5;648-652,
2017.

- 58 -

0415D003

Atsushi Sekimura, Takashi Yoshimatsu, Naoki Yamashita, Hanae Higa, Takeaki Miyata, Daigo Kawano, Tetsuya So,
Hidetaka Uramoto:Prediction of Pleural Adherence Area Used by Ultrasound Sonography, The Japanese Journal ofThoracic Surgery, 70:10;819-821, 2017.

0415D004

Matsui Takuma, Motono Nozomu, Machida Yuichiro, Usuda Katsuo, Uramoto Hidetaka:A case of primary
myoepithelial carcinoma of lung that was difficult to diagnose preoperatively, The Journal of the Japanese
Association for Chest Surgery, 31:5;633-637, 2017.

0415D005

Nozomu Motono, Aika Funasaki, Astushi Sekimura, Katsuo Usuda, Masahito Kawaguchi, Norio Kawahara, Hidetaka
Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lung cancer invading the spine,
Journal of Cancer Science and Research, 3:S1, 2017.

Presentations at Conference
International Conference (Presentations)
0415I001

Katsuo Usuda, Nozomu Motono, Makoto Tanaka, Yuichiro Machida, Takuma Matsui, Munetaka Matoba, Hidetaka
Uramoto:Diagnostic performance of diffusion weighted imaging for multiple hilar and mediastinal lymph nodes FDG
accumulation, BIT's 10th Annual World CANCER Congress-2017, Barcelona, 2017.

0415I002

Nozomu Motono:Sphingosine kinase1(SPHK1)promoters proliferation and surnival in non-small cell lung cancer,
IASLC 18TH World conference on lung cancer, Yokohama, 2017.

0415I003

M.Doai, N.Tsuchiya, H.Tonami, K.Usuda, H.Uramoto, M.Matoba:Whole-lesion evaluation of lung adenocarcinoma
for predicting pathological grade:Comparative study between histogram Parameters of ADC on DWI,and MTV aswell as TLG on 18F-FDG PET/CT., The 103nd Scientific Assembly & Annual Meeting of the Radiological Societyof North America Annual Meeting, Chicago, 2017.11.

- 59 -

0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUJITA Hideto

Surgical treatment of gastric cancer,

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

MORIOKA Emi

Surgery of Digestive Diseases

Assistant Professor

FUJITA Jun

Surgery of Digestive Diseases

Assistant Professor

MIURA Seiko

Assistant Professor

FUJII Yoritaka

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics,

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Publications
Originals
0420B001

Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of
18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients.,
Breast cancer, 24:1;121-127, 2017.

- 60 -

0420B002(Masazumi Takahashi), Masanori Terashima, Hiroshi Kawahira, Eishi Nagai, Yoshikazu Uenosono, Shinichi Kinami,
Yasuhiro Nagata, Masashi Yoshida, Keishiro Aoyagi, Yasuhiro Kodera, Koji Nakada:Quality of life after total vsdisital gastrectomy with Roux-en-Y reconstruction: Use of the postgatrectomy syndrome assessment scale-45,
World Journal of Gastroenterology, 23:11;2068-2076, 2017.

0420B003(Asako Sasahara), Kana Tominaga, Tatsunori Nishimura, Masao Yano, Etsuko Kiyokawa, Miki Noguchi, Masakuni
Noguchi, Hajime Kanauchi, Toshihisa Ogawa, Hiroshi Minato, Keiichiro Tada, Yasuyuki Seto, Arinobu Tojo, Noriko
Gotoh:An autocrine / paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance ofbreast cancer stem-like cells, Oncotarget, 8:15;24869-24881, 2017.

0420B004

Toshio Ohnishi, Shinici Kinami, Yoritaka Fujii, Seiko Miura, Jun Fujita, Daisuke Kaida, Yasuto Tomita, Hideto
Fujita, Yasuharu Nakano, Nobuhiko Ueda, Takeo Kosaka:Prognosis of conversion gatrectomy cases for stage Ⅳ
gastric cancer, Japanese Journal of Cancer and Chemotherapy, 44:12;1799-1801, 2017.

0420B005

Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi
Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.

0420B006

Shinich Kinami, Toshio Ohnishi, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Hideto Fujita, NobuhikoUeda, Yasuharu Nakano, Takeo Kosaka:ICG fluorescence sentinel node biopsy for early gastric cancer, Japanese
Journal of Lymphology, 40:2;107-112, 2017.

Reviews
0420C001

Shinichi Kinami, Takeo Kosaka:Laparoscopic sentinel node navigation surgery for early gastric cancer,
Translational Gastroenterology and Hepatology, 2:42, 2017.

Case Reports
0420D001

Toshio Onishi, Shinichi Kinami, Yasuto Tomita, Hideto Fujita, Nobuhiko Ueda, Takeo Kosaka:Desmoid-type
fibromatosis after laparoscopic endoscopic co-operative surgery for a gastrointestinal stromal tumor of stomach A case report -, Journal of Japan Surgical Association, 78:5;988-993, 2017.

0420D002

Seiko Miura, Nobuhiko Ueda, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano, Takeo Kosaka, Noriaki Sakata,
Ryouhei Nishino:A case unresectable gastric cancer with multiple metastases responding to chemotherapy,
Japanese Journal of Cancer and Chemotherapy, 44:12;1781-1783, 2017.

0420D003

Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi
Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due tocombination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer andChemotherapy, 44:12;1373-1375, 2017.

Presentations at Conference
International Conference (Key Note Lecture)
0420G001

Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2)
in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.

International Conference (Presentations)
0420I001

Seiko Miura, Nobuhiko Ueda, Toshio Onishi, Yasuto Tomita, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano,Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Multilocular cystic intrahepaticcholangiocarcinoma : A case report, Joint Congress of The 6th Biennial Congress of the Asian-Pacific HepatoPancreato-Billiary Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery,
Yokohama, 2017.06.

0420I002

Nobuhiko Ueda, Seiko Miura, Yasuto Tomita, Toshio Onishi, Hideto Fujita, Shinichi Kinami, Yasuharu Nakano,Takeo Kosaka, Akane Aikawa, Hiroshi Minato, Takayuki Nojima:Surgical management of intraducyal papillary
mucinous neoplasms, Joint Congress of The 6th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Billiary
Associaion. The 29th Meeting of Japanese Society of Hepato-Billiary-Pancreatic Surgery, Yokohama, 2017.06.

- 61 -

0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAHARA Norio

Spinal surgery

Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Professor

MATSUMOTO Tadami Hip surgery

Associate Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Senior Assistant Professor

FUKUI Kiyokazu

Hip surgery

Senior Assistant Professor

HIROMURA Kentaro

TraumaSenior Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

ORITA Yugo

Spinal surgery, orthopaedic surgery

Assistant Professor

TAKAHASHI Eiji

Hip surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Assistant Professor

SHIMIZU Yoshiaki

Spinal surgery

Assistant Professor

UEDA Shusuke

Hip surgery

Assistant Professor

TSUDA Ryoji

Hip surgery

Assistant Professor

SOMA Daisuke

orthopadeic Surgery

Assistant Professor

YONEZAWA
KatsutakaSpinal surgery, orthopaedic surgery

Assistant Professor

KANEKO Seiji

Hip surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, implant coating.

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we perform a study to make antibacterial implant to prevent SSI. We confirmed that fluoride added DLC
coating does not have cytotoxicity, and its bactericidal effect for staphylococcus aureus and E.coli. We are going tocontinue this study for manufacture.

- 62 -

Publications
Originals
0430B001

Toru Ichiseki, Shusuke Ueda, Yoshimichi Ueda, Masanobu Tuchiya, Ayumi Kaneuji, Norio Kawahara:Involvement of
necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model, International
journal of medical sciences, 14:110-114, 2017.

0430B002(Kensei Yoshimoto), Yasuharu Nakashima, Shigeo Aota, Ayumi Kaneuji, Kiyokazu Fukui, Kazuo Hirakawa, Nariaki
Nakura, Koichi Kinoshita, Masatoshi Naito, Yukihide Iwamoto:Re-dislocation after revision total hip arthroplasty
for recurrent dislocation: a multicentre study, International orthopaedics, 41:253-258, 2017.

0430B003

Eiji Takahashi, Ayumi Kaneuji, Ryoji Tsuda, Yuhei Numata, Toru Ichiseki, Kiyokazu Fukui, Norio Kawahara:The
influence of cement thickness on stem subsidence and cement creep in a collarless polished tapered stem: When
are thick cement mantles detrimental?, Bone & joint research, 6:351-357, 2017.

0430B004(A.Amelot), L.Balabaud, D.Choi, Z.Fox, HA.Crockard, T.Albert, CM.Arts, JM.Buchowski, C.Bunger, CK.Chung,
MH.Coppes, B.Depreitere, MG.Fehlings, J.Harrop, N.Kawahara, ES.Kim, CS.Lee, Y.Leung, ZJ.Liu, JA.MartinBenlloch, EM.Massicotte, B.Meyer, FC.Oner, W.Peul, N.Quraishi, Y.Tokuhashi, K.Tomita, C.Ulbricht, JJ.Verlaan,
M.Wang, C.Mazel:Surgery for metastatic spine tumors in the elderly. Advanced age is not a contraindication tosurgery!, The spine journal, 17:759-767, 2017.

0430B005(Kyoko Kondo), Seiya Jingushi, Satoko Ohfuji, Muroto Sofue, Moritoshi Itoman, Tadami Matsumoto, Yoshiki
Hamada, Hiroyuki Shindo, Yoshio Takatori, Harumoto Yamada, Yuji Yasunaga, Hiroshi Ito, Satoshi Mori, IchiroOwan, Genji Fujii, Hirotsugu Ohashi, Wakaba Fukushima, Akiko Maeda, Miki Inui, Shinji Takahashi, Yoshio Hirota:Factors associated with functional limitations in the daily living activities of Japanese hip osteoarthritis patients,
International journal of rheumatic diseases, 20:1372-1382, 2017.

0430B006(Kazuhiro Shintani), Takuya Kobayashi, Masahito Kawaguchi, Norio Kawahara, Ayumi Kaneuji:Causes of highosteoconductivity of 3D honeycomb artificial footing material with DLC coating, Japanese Journal of Clinical
Biomechanics, 38:213-218, 2017.

0430B007(Hideaki Kawakami), Katsutaka Yonezawa, Kazuhiro Shintani, Norio Kakawaha:Study on application of si3n4-hbn
ceramics to the vertebral body, Japanese Journal of Clinical Biomechanics, 38:207-211, 2017.

0430B008

Shusuke Ueda, Miyako Shimasaki, Toru Ichiseki, Yoshimichi Ueda, Masanobu Tsuchiya, Ayumi Kaneuji, Norio
Kawahara:Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal
stem cells in a rabbit model, BMC musculoskeletal disorders, 18:480, 2017.

0430B009(Yuma Sakamoto), Takuaki Yamamoto, Nobuhiko Sugano, Daisuke Takahashi, Toshiyuki Watanabe, Takashi
Atsumi, Junichi Nakamura, Yukiharu Hasegawa, Koichi Akashi, Ichiei Narita, Takeshi Miyamoto, Tsutomu
Takeuchi, Katsunori Ikari, Koichi Amano, Atsuhiro Fujie, Toshikazu Kubo, Yoshifumi Tada, Ayumi Kaneuji,
Hiroaki Nakamura, Tomoya Miyamura, Tamon Kabata, Ken Yamaji, Takahiro Okawa, Akihiro Sudo, Kenji Ohzono,
Yoshiya Tanaka, Yuji Yasunaga, Shuichi Matsuda, Yuuki Imai, Japanese Research Committee on Idiopathic
Osteonecrosis of the Femoral Head, Masato Akiyama, Michiaki Kubo, Yoichiro Kamatani, Yukihide Iwamoto, Shiro
Ikegawa:Genome-wide association study of idiopathic osteonecrosis of the femoral head, Scientific reports,
7:15035, 2017.

Case Reports
0430D001

Toru Ichiseki, Shusuke Ueda, Ayumi Kaneuji, Norio Kawahara:Massive tear of an ossified supraspinatus tendon: acase report and review of the literature, International journal of clinical and experimental medicine, 10:1429-1433,
2017.

0430D002

Norio Kawahara, Hidetaka Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lungcancer invading the spine, Journal of Lung Cancer Diagnosis & Treatment, 2:4;118, 2017.

0430D003

Nozomu Motono, Aika Funasaki, Astushi Sekimura, Katsuo Usuda, Masahito Kawaguchi, Norio Kawahara, Hidetaka
Uramoto:Dividing the procedures into lobectomy and vertebrectomy for large lung cancer invading the spine,
Journal of Cancer Science and Research, 3:S1, 2017.

- 63 -

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

Norio Kawahara:Surgery for spinal metastasis from RCC, 16th Korean Spine Oncology Research Society, Seoul,2017.08.

0430G002

Norio Kawahara:Total en-bloc spondylectomy of the lumbar spine, 16th Korean Spine Oncology Research Society,
Seoul, 2017.08.

0430G003

Norio Kawahara:TES in special focus into the lumbar spine, AOSpine Principles Course in Management ofVertebral Tumors, Manila, 2017.11.

0430G004

Norio Kawahara:Reconstruction/fixation and fusion techniques after en bloc resection, AOSpine Principles Course
in Management of Vertebral Tumors, Manila, 2017.11.

0430G005

Norio Kawahara:Soft tissue and wound reconstruction techniques in spinal tumor surgery, AOSpine Principles
Course in Management of Vertebral Tumors, Manila, 2017.11.

International Conference (Symposium)
0430H001

Ayumi Kaneuji, Kiyokazu Fukui, Toru Ichiseki, Norio Kawahara:Total hip arthroplasty after rotational acetabularosteotomy, 2017 ICJR Japan (International Congress for Joint Reconstruction), Tokyo, 2017.04.

International Conference (Presentations)
0430I001(CR.Bragdon), CJ.Barr, CS.Nielsen, D.Berry, CJ.Della Valle, K.Garvin, PE.Johansson, J.Clohisy, A.Kaneuji,
H.Malchau:Minimum 10-13 year multi-center study of THA with highly cross-linked polyethylene and ceramic or
cobalt chrome femoral heads, The 2017 AAHKS Annual Meeting, Dallas, 2017.11.

- 64 -

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Professor

TAKADA Hisashi

cerebrovascular disease，endovascular therapy

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Senior Assistant Professor

SIRAGA Syunsuke

cerebrovascular disease

Assistant Professor

TAMASE Akira

spinal disease

Assistant Professor(Additional Post)

TSUKADA Tsuyoshi

General Neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis- 65 -

Publications
Originals
0440B001(Y.Sasagawa), Y.Hayashi, O.Tachibana, M.Oishi, I.Fukui, H.Iizuka, M.Nakada:Clinical characteristics ofacromegalic patients with empty sella and their outcomes following transsphenoidal surgery, Pituitary, 20:4;403408, 2017.

0440B002(I.Fukui), Y.Hayashi, D.Kita, Y.Sasagawa, M.Oishi, O.Tachibana, M.Nakada:Significant Improvement in Chronic
Persistent Headaches Caused by Small Rathke Cleft Cysts After Transsphenoidal Surgery, World Neurosurgery,
99:362-368, 2017.

0440B003(Y.Hayashi), Y.Sasagawa, D.Kita, I.Fukui, M.Oishi, O.Tachibana, F.Ueda, M.Nakada:Contribution of sellar dura
integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage, Pituitary, 20:5;531-538,
2017.

0440B004(Y.Hayashi), D.Kita, I.Fukui, Y.Sasagawa, M.Oishi, O.Tachibana, F.Ueda, M.Nakada:Preoperative Evaluation of
the Interface Between Tuberculum Sellae Meningioma and the Optic Nerves on Fast Imaging with Steady-State
Acquisition for Extended Endoscopic Endonasal Transsphenoidal Surgery, World Neurosurgery, 103:153-160,
2017.

Presentations at Conference
International Conference (Presentations)
0440I001

O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada ,A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya,
M.Nakada,H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of
Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th
Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.

- 66 -

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA Akiko

Plastic and Reconstructive Surgery

Senior Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

YAGISHITA Mikio

Plastic and Reconstructive Surgery

Assistant Professor

SAKAGAMI Akihiko

Plastic and Reconstructive Surgery

Assistant Professor

YONEZAWA Minami

Assistant Professor

KAWAMURA Ryo

Assistant Professor

TAKEMURA Tomoko

Assistant Professor

MAKIMOTO Kazuhiko

Assistant Professor

MORIMOTO Yayoi

Assistant Professor

IGAWA Yuichi

Plastic and Reconstructive Surgery

Keywords of Researchfibroblast, FGF receptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocyte, wound healing, craniofacial surgery,zygoma, cleft lip, cleft palate, microtia, tissue expansion, crainofacial cleft, front-orbital advancement, microsurgery, freeflap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in congenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

- 67 -

Publications
Originals
0450B001

Mikio Yagishita, Haruhisa Daizo, Toru Miyanaga, Kenichi Shimada:Donor Site Morbidity in Cross Finger Flaps, J
Jpn Soc Surg Hand, 34:3;400-404, 2017.

0450B002

Toru Miyanaga, Kenichi Shimada, Miyuki Kishibe, Masanobu Yamashita, Akiko Yamashita:The Double Volar Flap
Technique for Aesthetic Repair of Syndactyly and Polysyndactyly of Toe without Skin Grafting, PLASTIC ANDRECONSTRUCTIVE SURGERY, 5:4;e1293, 2017.

- 68 -

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Senior Assistant Professor

YOSHIZAKI Hisayoshi Pediatric surgery

Senior Assistant Professor

YASUI Yoshitomo

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Assistant Professor

SATOMI Miwa

Pediatric surgery

Assistant Professor

SHIRONOMAE
Tsubasa

Pediatric surgery

Faculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma,

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001(M.Sato), Y.Hamada, M.Kohno, K.Ise, K.Uchida, H.Ogata, H.Masuyama, Y.Morotomi, M. Yasufuku, M.Wada:
Neonatal gastrointestinal perforation in Japan: a nationwide survey., Pediatr Surg Int, 33:33-41, 2017.

0460B002

Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui:
Endoscopic Marsupialization of a Laryngeal Cyst in a Neonate: A Case Report, Journal of the Japanese Society ofPediatric Surgeons, 53:911-915, 2017.

0460B003

Y.Yasui, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, M.Kohno:Surgical approach for fecal incontinence witha patulous anus after transanal pull-through for Hirschsprung disease, Journal of pediatric surgery, 52:6;10701075, 2017.

0460B004

Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno,
Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of Nacetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.

0460B005

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

- 69 -

Case Reports
0460D001

Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui:TWO
PEDIATRIC CASES OF ECTOPIC ADRENAL TISSUE IN THE SPERMATIC CORD, 26:1;73-75, 2017.

0460D002

Tsubasa Shironomae, Miyuki Kohno, Shoichi Nishida, Miwa Satomi, Tsuyoshi Kuwahara, Yoshitomo Yasui:
Endoscopic Marsupialization of a Laryngeal Cyst in a Neonate: A Case Report, 53:911-915, 2017.

0460D003

Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hairhypoplasia associated with isolated hypoganglionosis: A case report, CONGENITAL ANOMALIES, 57:1;32-34,
2017.

- 70 -

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis, electromagnetic ocular injury,
ultraviolet

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiology

Associate Professor

FUKUDA Masamichi

ocular pharmacology, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

cataract

Senior Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology, oxidative stress and eye disease

Senior Assistant Professor

SHIBATA Naoko

cataract, ophthalmology, oxidative stress and eye disease

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Assistant Professor

OSADA Hiromi

cataract, ophthalmology, macular degeneration

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics, epidemiology, ultraviolet

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

SHIBATA Teppei

cataract, oxidative stress and eye disease

Assistant Professor

MIYASHITA Hisanori cataract, epidemiology

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystalline lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herpetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland, China and Tanzania). These studies have included prevalence,incidence and risk factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we
have worked on image analysis of the crystalline lens, drew up a new classification system for cataract, and done researchon visual performance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using
animal models and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative
drug for PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

- 71 -

Publications
Originals
0470B001(Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Amyloid β1-43 Accumulates inthe Lens Epithelium of Cortical Opacification in Japanese Patients, Investigative Ophthalmology & Visual Science,
58:3294-3302, 2017.

0470B002

Hiroshi Sasaki:Primary and secondary preventions of cataracts, Rinsho Ganka, 71:1;52-60, 2017.

0470B003(Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:A positive feedback loop between nitricoxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, Toxicology, 381:1930, 2017.

0470B004

E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ
regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.

0470B005(Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru
Kinoshita:Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed
disposable pipette, British Journal Of Ophthalmology, 101:548-550, 2017.

0470B006(Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara:Multiple comparisons in two-factor
testing of psychophysical thresholds by the delta test method, Communications in statistics-simulation andcomputation, 46:1;669-678, 2017.

0470B007(Bhavana Chhunchha), Eri Kubo, Nigar Fatma, Dhirendra P Singh:Sumoylation-deficient Prdx6 gains protectivefunction by amplifying enzymatic activity and stability and escapes oxidative stress-induced aberrant Sumoylation,
Cell Death and Disease, 8:e2525;1, 2017.

0470B008

Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh:Sulforaphane reactivates cellularantioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Scientific reports,
7:14130, 2017.

0470B009

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

0470B010(Toshiyuki Hayashida), Hiroshi Sasaki, Nobuyuki Hamada, Hideo Tatsuzaki, Natsuko Hatsusaka, Keiichi Akahane,
Sumi Yokoyama:Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo
Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects
to the Lens-, Japanese Journal of Health Physics, 52:2;88-99, 2017.

Case Reports
0470D001

Nobuyuki Fujita, Teppei Shibata, Masamichi Fukuda, Kazuyuki Sasaki, Hiroshi Sasaki:An ease ｗith successfultreatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Folia Japanica deOphthalmologica Clinica, 10:12;1007-1010, 2017.

Presentations at Conference
International Conference (Symposium)
0470H001

Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.

International Conference (Presentations)
0470I001

Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi
Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.

- 72 -

0470I002

Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo,
Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.

0470I003

Eri Kubo, Shinsuke Shibata, Teppei Shibata, Naoki Tanimura, Dhirendra P. Singh, Hiroshi Sasaki:FGF2-mediatedinduction of microRNA29c and its regulation of Tropomyosin, The Association for Research in Vision andOphthalmology, Baltimore, 2017.

0470I004

Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Naoki Tanimura, Hiroshi Sasaki, Eri Kubo:Effects ofproteoglycan decorin on lens epithelial cells, The Association for Research in Vision and Ophthalmology,
Baltimore, 2017.

0470I005

Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene
expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.

0470I006

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.

0470I007

Hidetoshi Ishida, Norihiro Mita, Eri Kubo, Mai Kita, Aya Nakano, Yuuki Ukai, Ayako Okamoto, Naoko Shibata, Eri
Kubo, Hiroshi Sasaki:Comparison of the postoperative stability of the three types of single-piece intraocularlenses, The Association for Research in Vision and Ophthalmology, Baltimore, 2017.

0470I008

Eri Shibuya, Mai Sasaki, Norihiro Mita, Ayako Okamoto, Mai Kita, Hiromi Osada, Naoko Shibata, Yoriko
Takahashi, Eri Kubo, Hiroshi Sasaki:Posterior capsular wrinkle in eyes with 2 types of 1-piece intraocular lens,
The Association for Research in Vision and Ophthalmology, Baltimore, 2017.

0470I009(Bhavana Chhunchha), Eri Kubo, Hiroshi Sasaki, Dhirendra P. Singh:Switching of redox signaling by sulforaphane
determines lens epithelial cells fate by hormetic mechanisms involving Prdx6/Nrf2 and Klf9 pathways, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.

0470I010(Dhirendra P Singh), Bhavana Chhunchha, Prerna Singh, W Daniei Stamer, Eri Kubo:Stabilization of Prdx6 activity
by targeted mutation of sumoylation sites protects trabecular meshwork cells from oxidative damage, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.05.

0470I011(Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J Chakarothai, Kensuke Sasaki,
Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage
induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.

0470I012

Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORTTERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.

0470I013

Hiroshi Sasaki, Ayako Okamoto, Naoko Shibata, Eri Shibuya, Norihiro Mita, Hidetoshi Ishida, Eri Kubo:Influence
on toric intraocular lems axis by incision misalignment:a simulation study, European Society of Cataract &Refractive Surgens, Lisbon, 2017.

0470I014

Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.

0470I015

Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami
Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.

0470I016

Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Hiroshi Sasaki, Eri Kubo:Expression of decorin, and its relation
to posterior capsular opacification, International Conference on the Lens, kona, 2017.

0470I017

Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.

- 73 -

0470I018

Norihiro Mita, Aya Nakano, Yuuki Ukai, Ayako Takayama, Eri Sibuya, Mai Kita, Hiromi Osada, Hisanori Miyashita,
Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Analysis of transparent lens formation in mid-and old-age by anterior
segment OCT, International Conference on the Lens, Kona, 2017.

0470I019

Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P Singh:Sulforaphane reactivates cellularantioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, International
Conference on the Lens, Kona, 2017.

0470I020

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Knock-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.

- 74 -

0475

Department of Otorhinolaryngology

Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Associate Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology, Otology

Senior Assistant Professor

YAO Toru

Otology, Rhinology

Senior Assistant Professor

SAKAI Aya

Sleep apnea syndrome

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

NODA Takuya

General otorhinolaryngology

Assistant Professor

YAMADA Kentaro

General otorhinolaryngology

Assistant Professor

INAGAKI Shingo

General otorhinolaryngology

Assistant Professor

HARITA Masayuki

General otorhinolaryngology

Faculty

Keywords of Researcholfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep
apnea & snoar surgery

Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Yao, Yamamoto, Yamada, Noda,
Harita)New educational system for endoscopic sinus surgery(Miwa , Shiga, Yao)
Clinical research for snoar and sleep apnea(Miwa, Sakai)

Publications
Originals
0475B001

Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo,
Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patientswith idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.

Reviews
0475C001

Noda Takuya, Tsuji Hiroyuki:Prevention of Frey's Syndrome Following a Parotid Gland Surgery with a Platysma
Flap, Practica Oto-Rhino-Laryngologica, 110:1;4-5, 2017.

Case Reports
0475D001

Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji,
Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.

- 75 -

Short Communications
0475E001

Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi
Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.

Others0475F001(T.Hummel), K.L.Whitcroft, P.Andrews, A.Altundag, C.Cinghi, R.M.Costanzo, M.Damm, J.Frasnelli, H.Gudziol,
N.Gupta, A.Haehner, E.Holbrook, S.C.Hong, D.Hornung, K.B.Hüttenbrink, R.Kamel, M.Kobayashi,
I.Konstantinidis, B.N.Landis, D.A.Leopold, A.Macchi, T.Miwa, R.Moesges, J.Mullol, C.A.Mueller, G.Ottaviano,
G.C.Passali, C.Philpott, J.M.Pinto, V.J.Ramakrishnan, P.Rombaux, Y.Roth, R.A.Schlosser, B.Shu, G.Soler,
P.Stjärne, B.A.Stuck, J.Vodicka, A.Welge-Luessen:Position paper on olfactory dysfunction, RHINOLOGY, 54:130, 2017.

Presentations at Conference
International Conference (Key Note Lecture)
0475G001

Takaki Miwa:Treatment of post-infectious olfactory dysfunction, International congress of ORL-HNS2017, Seoul,2017.04.

International Conference (Symposium)
0475H001

Takaki Miwa:How to set up a smell clinic, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.08.

0475H002

Takaki Miwa:Treatment of postinfectious olfactory dysfunction, Rhinology world congress - Hong Kong 2017, Hong
Kong, 2017.09.

0475H003

Hideaki Shiga:Thallium-201 based "olfacto-scintigraphy" for traumatic smell loss patients, Rhinology world
congress - Hong Kong 2017, Hong Kong, 2017.09.

0475H004

Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective lowpressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society ofThyroid Surgery, Naha, 2017.11.

International Conference (Presentations)
0475I001

Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa:
Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after
upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.

0475I002

Takuya Noda, Hideaki Shiga, Kentaro Yamada, Hideaki Ninomiya, Takaki Miwa:Effects of herbal medicine on
regeneration of olfactory neurons in mice, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.09.

0475I003

Kentaro Yamada, Hideaki Shiga, Takuya Noda, Takaki Miwa, Hideaki Ninomiya:Effects of ovariecotmy onregeneration of olfactory neuron in mice, Rhinology world congress - Hong Kong 2017, Hong Kong, 2017.09.

- 76 -

0485

Department of Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

KISHIMOTO Kazuhiro Head and neck surgery

Assistant Professor

KAWAKAMI Osamu

Head and neck surgery

Keywords of Researchhead and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle
aspiration cytology, chemoradiotherapy

Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode)
New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government
cooperation (Tsuji, Shimode)
Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji,
Shimode)Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)

Publications
Originals
0485B001

Matoba Munetaka, Tuji Hiroyuki, Shimode Yuzo, Kondo Tamaki, Oota Kiyotaka, Tonami Hisao:The role ofchanges in maximum standardized uptake value of FDG PET-CT for post-treatment surveillance in patients withhead and neck squamous cell carcinoma treated with chemoradiotherapy: preliminary findings, BRITISH JOURNAL
OF RADIOLOGY, 90:20150404, 2017.

Reviews
0485C001

Noda Takuya, Tsuji Hiroyuki:Prevention of Frey's Syndrome Following a Parotid Gland Surgery with a Platysma
Flap, Practica Oto-Rhino-Laryngologica, 110:1;4-5, 2017.

Case Reports
0485D001

Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji,
Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.

Short Communications
0485E001

Yuzo Shimode, Hiroyuki Tsuji, Takahiro Fukuhara, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Kazuhiro Kishimoto, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takayuki Nojima, Hiromi
Takeuchi:Examination of Selective Low-pressure Fine Needle Aspiration Cytology Under Ultrasound Guidance,
YONAGO ACTA MEDICA, 60:3;209-212, 2017.

- 77 -

Presentations at Conference
International Conference (Symposium)
0485H001

Yuzo Shimode, Hiroyuki Tsuji, Kazuhiro Kishimoto, Osamu Kawakami, Toshiki Tsutsumiuchi, Takuya Noda,
Kentaro Yamada, Satoko Nakata, Rie Terauchi, Mariko Nakano, Takahiro Fukuhara:Examination of selective lowpressure fine needle aspiration cytology under ultrasound guidance, 2nd Congress of Asia-Pacific Society ofThyroid Surgery, Naha, 2017.11.

0485H002

Yuzo Shimode:Ultrasonography and FNA/Core needle biopsy, 2nd Congress of Asia-Pacific Society of Thyroid
Surgery, Naha, 2017.11.

- 78 -

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Senior Assistant Professor

TAKEDA Kiminobu

Medical mycology

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Assistant Professor

HATTA Jyunko

Image analysis

Associate Professor

WATANABE Seiji

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, Langerhans cell,

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Publications
Originals
0490B001

S.Watanabe, K.Anzawa, T.Mochizuki:High prevalence of superficial white onychomycosis by Trichophyton
interdigitale in a Japanese nurcing home with a geriatric hospital., Mycoses, 60:634-637, 2017.

0490B002(Tomoyuki Iwanaga), Tsuyoshi Ushigami, Kazushi Anzawa, Takashi Mochizuki:Pathogenic dermatophytes survive innail lesions during oral terbinafine treatment for tinea unguium, Mycopathologia, 182:673-679, 2017.

0490B003

T.Ushigami, K.Anzawa, T.Mochizuki:Molecular typing using polymorphisms of the polyketide synthase gene (PKS1)of strains in Japan morphologically identified as Fonsecaea pedrosoi., The Journal of Dermatology, 44:36-42, 2017.

0490B004

J.Watanabe, K.Anzawa, T.Mochizuki:Molecular epidemiology of Japanese isolates of Microsporum canis based on
multilocus microsatellite typing fragment analysis, Japanese Journal of Infectious Diseases, 70:544-548, 2017.

- 79 -

Reviews
0490C001

T. Mochizuki, K. Takeda, K. Anzawa.:Molecular markers useful for intraspecies subtyping and strain differentiationof dermatophytes., Mycopathologia, 182:57-65, 2017.

Case Reports
0490D001

Tomoko Sakamoto, Asuka Kitayama, Takashi Mochizuki:A case of reticulohistiocytic granuloma, Practical
Dermatology, 39:163-166, 2017.

0490D002(G.Tsuji), K.Takei, M.Takahara, T.Matsuda, T.Nakahara, K.Anzawa, T.Mochizuki, M.Furue, H.Uchi:Simultaneous
onset of sporotrichosis in mother and daughter., The Journal of Dermatology, 44:1068-1069, 2017.

0490D003(A.Ito), N.Yamada, N.Tanaka, J.Kurai, K.Anzawa, T.Mochizuki, O.Yamamoto:Concurrent double fungal infectionsof the skin caused by Phialemoniopsis endophytica and Exophiala jeanselmei in a patient with microscopic
polyangitis, Acta Dermato-Venereologica, 97:1142-1144, 2017.

0490D004(Y.Kawakami), S.Hirano, S.Mistui, M.Kuyama, A.Nishibu, K.Anzawa, T.Mochizuki:Case of inflammatory tinea
corporis affecting the dorsal surface of the thumb in a nail salon technician, The Journal of Dermatology, 44:e294e295, 2017.

0490D005

Seiji Watanabe, Kazushi Anzawa, Takashi Mochizuki:Case of mycotic cyst caused by Scedosporium apiospermum
developed liver dysfunction following administration of voriconazole, The Journal of Dermatology, 44:e296-e297,
2017.

Short Communications
0490E001

J Hatta, T Mochizuki:Successful treatment of plantar warts with topical glycolic acid, The Journal of Dermatology,
44:e134-e135, 2017.

- 80 -

0500

Department of Urology

Faculty
Title

Name

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

INOUE Shinya

general urology

Assistant Professor

NAKAZAWA Yusuke

general urology

Assistant Professor

FUKUDA Yuko

Assistant Professor

USHIMOTO
Chiharuko

Field of Specialization

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence,

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001

Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo,
Katsuhito.Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.

0500B002(Igor Sorokin), Charalampos Mamoulakis, Katsuhito Miyazawa, Allen Rodgers, Jamsheer Talati, Yair Lotan:
Epidemiology of stone disease across the world, World Journal of Urology, 35:1301-1320, 2017.

Case Reports
0500D001

Keiji Fujimoto, Masaru Nakagawa, Katsuaki Sato, Tatsuro Tanaka, Nobuhiko Miyatake, Keita Yamazaki, Yuko
Tsuruyama, Yuki Okushi, Kazuaki Okino, Kiyotaka Mukai, Katsuhito Miyazawa, Hitoshi Yokoyama:A patient withtuberous sclerosis in whom dialysis was introduced due to hemorrhaging from oncocytic papillary renal cell
carcinoma, Journal of Japanese Society for Dialysis Therapy, 50:93-100, 2017.

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0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

Professor

SASAGAWA Toshiyuki

Gynecologic Pathology, Tumor Virology, Sexually Transmitted
Infection Research, Immunology

Associate Professor

TAKAKURA Masahiro gynecologic oncology, perinatal medicine

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor(Additional Post)

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Assistant Professor

OSAKA Yasuhiro

perinatal medicine

Assistant Professor

SAKAMOTO Jinichi

perinatal medicine, reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

Publications
Originals
0510B001

T.Shibata, J.Sakamoto, Y.Osaka, N.Neyatani, S.Fujita, Y.Oka, T.akagi, H.Mori, H.Fujita, Y.Tanaka, T.Sasagawa:
Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women ofreproductive age,
Int J Lab Hematol, 39:169-174, 2017.

- 82 -

0510B002

M.Takahashi P.Mohan K.Mukai Y.Takeda T.Matsumoto K.Matsumura M.Takakura H.Arai T.Taguchi S.Maenosono:
Magnetic Separation of Autophagosomes from Mammalian Cells Using Magnetic–Plasmonic Hybrid Nanobeads, ACS
Omega, 2:4929-4937, 2017.

Case Reports
0510D001

Shin Toki, Masatsune Itoh, Nobuhiro Okamoto, Azusa Kobayashi, Kentaro Yamada, Yuzo Shimode, Hiroyuki Tsuji,
Takeo Shibata, Toshiyuki Sasagawa, Yutaka Saikawa:Multidisciplinary management of multiple endocrine neoplasia
type 1 during pregnancy, 53:3;905-908, 2017.

Presentations at Conference
International Conference (Presentations)
0510I001

T.Sasagawa, Y.Osaka, J. Sakamoto, T.Shibata, A.Hiroguchi, S.Fujita, H.Takagi, T.Maehama:Effectiveness of anovel ablation therapy using phenol for cervical or vaginal intraepithelial neoplasia (CIN/ VAIN), 31th International
Papillomavirus Conferenc, Capetown, 2017.02.

0510I002

A.Hiroguchi, Y.Osaka, J.Sakamoto, T.Shibata, H.Minato, T.Sasagawa:Identification of HPV infection type for
Squamous cell carcinoma, 31th International Papillomavirus Conference, Capetown, 2017.02.

0510I003

T.Sasagawa, J.Sakamoto, Y.Osaka, T.Shibata, S.Fujita, M.Takakura, H.Takagi:A new ablation therapy using liquid
phenol for cervical and vaginal squamous intraepithelial lesions (SILs) , AOGIN 2017 Tokyo Meeting, Tokyo,
2017.10.

- 83 -

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Senior Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, Shock

Senior Assistant Professor

HONMA Keiko

Clinical anesthesia, Palliative medicine

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

TAKANO Mami

Clinical anesthesia

Assistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

TAKAHARA Asami

Clinical anesthesia

Assistant Professor

KANEKO Yuriko

Clinical anesthesia

Assistant Professor

MORIKAWA Takanori Clinical anesthesia

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

UEDA Keiko

Clinical anesthesia

Assistant Professor

MATUBA Sho

Clinical anesthesia

Assistant Professor

MIYAJIMA Saki

Clinical anesthesia

Assistant Professor

OGAWA Miho

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Reviews
0520C001

Hideaki Tsuchida:The Reason the Japanese Society for Geriatric Anesthesia Initiated a Certification System,
Journal of Clinical Anesthesia (Japan), 41:6;854-856, 2017.

Case Reports
0520D001

Akiko Hiramatsu, Hiromasa Kida, Hideaki Tsuchida:Elective Surgery was Postponed in a Patient with
Hematopoietic Malignancy due to Bleeding from the Insertion Site of an Epidural Catheter: A Case Report, The
Japanese Journal of Anesthesiology, 66:1;62-64, 2017.

- 84 -

0520D002

Masao Ogawa, Michiko Michibuchi Takanori Wagatsuma, Mikako Nishikawa, Yasuhiro Kawasaki, Hideaki Tsuchida,
Kanako Teraguchi:A Case Whose Delirium Improved with Discontinuation of Continuous Deep Sedation Initiatedfor Refractory Delirium at the End Stage of Cancer, Palliative Care Research, 12:1;501-505, 2017.

0520D003

Masao Ogawa, Hideaki Tsuchida:Effective treatment of glossopharyngeal neuralgia using steroid pulse therapy: acase report, Journal of Japan Society of Pain Clinicians, 24:4;336-340, 2017.

Presentations at Conference
International Conference (Symposium)
0520H001

Masao Ogawa:Kampo Case Reporting in the Era of Evidence-based Medicine, World Congress for Integrative
Medicine and Health 2017, Berlin, 2017.

International Conference (Presentations)
0520I001

T.Morikawa, H.Tsuchida:Effects of ischemic preconditioning on tourniquet-induced reperfusion injury ingastrocnemius muscles of rats, Annual Meeting of the American Society of Anesthesiolosits, Boston, 2017.

- 85 -

0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAGECHIKA Kenjirehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction

Assistant Professor

TORIGOE Keiichiro

general neurosurgery

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL,

Outline of Research1)Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
2)For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
3)We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
4)We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0540B001

Fumio Nogata, Yoko Kawamura, Taro Goto, Yasunai Yokota, William R.Walsh, Kenji Kagechika:Stiffness
Estimation from Arterial Wall Vibration and its Application, International Journal of Computer and Information
Technology, 6:1;7-13, 2017.

0540B002

Keisuke Irie, Hirokatsu Iseki, Satomi Okamoto, Seiji Nisimura, Akio Kobe, Kenji Kagechika:Validity andresponsiveness of the Simple Test for Evaluating Hand Function, Hand Therapy, 30:1-6, 2017.

Case Reports
0540D001

Yasutaka Takagi, Hiroshi Yamada, Hidefumi Ebara, Hiroyuki Hayashi, Takeshi Iwanaga, Kengo Shimozaki,
Yoshiyuki Kitano, Kagechika, Hiroyuki Tsuchiya:Thoracic spondylolisthesis and spinal cord compression in diffuse
idiopathic skeletal hyperostosis:a case report, Jornal of Medical Case Reports, 11:90, 2017.

Presentations at Conference
International Conference (Presentations)
0540I001

K.Kagechika:Validity and responsiveness of the Simple Test for Evaluating Hand Function, APFSSH 2017, Cebu,
2017.

- 86 -

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

WATANABE Atsushi

Emergency

Assistant Professor

USHIMOTO Tomoyuki Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care,

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

- 87 -

0570

Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Professor

KASAMAKI Yuji

Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

TAKAMURA Akiteru
USUDA Daisuke

Field of Specialization, Cardiology, General Practice,Electrocardiology, Arrhythmia, Echocardiography
Community-based Medical Education，Community Medicine，General
Practice，General Paediatrics
General Medicine

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy,

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

Noda Yoko, Iinuma Yoshitsugu, Usuda Daisuke, Taga Mitsutoshi, Shinmachi Miyuki, Maeda Kazumi, Maeno
Toshiko:Revising the Hygiene Maintenance of Urine Disposal Facilitated the Appropriate Indication of Urine
Collection, Japanese Journal of Environmental Infections, 32:1;23-28, 2017.

0570B002

Kawamura Kae, Iinuma Yoshitsugu, Usuda Daisuke, Hashimoto Aya, Matsumoto Masami, Tanaka Yoshi:Evaluationof automated urine particle analyzer, UF-5000, as a screening tool to identify Gram stainability of urinal
pathogens, Japanese Journal of Medical Technology, 66:5;516-523, 2017.

0570B003

Takamura Akiteru, Ito Sayori, Maruyama Kaori, Ryo Yusuke, Saito Manami, Fujimura Shuhei, Ishiura Yuna, Hori
Ariyuki:Quality of basic life support education and automated external defibrillator setting in schools in Ishikawa,Japan, PEDIATRICS INTERNATIONAL, 59:3;352-356, 2017.

0570B004

Takamura Akiteru, Misaki Hidekazu, Takemura Yousuke:Community and Interns' Perspectives on CommunityParticipatory Medical Education: From Passive to Active Participation., Family medicine, 49:7;507-513, 2017.

Reviews
0570C001

A.Takamura, M.Matsumoto, S.Ishikawa:Rural Health in Japan: Past and future., Rural and Remote Health,
17:4;4521-, 2017.

Case Reports
0570D001

Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda
Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic
erythroderma: a case report, Journal of medical case reports, 11:1;35, 2017.

- 88 -

0570D002

Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri
without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.

0570D003

A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated byrenal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.

0570D004

Akiteru Takamura, Ariyuki Hori:Recurrent Translent Perivascular Inflammation of the Carotid artery syndrome
with temporary carotid plaque on ultrasonography: a case report, Clinical Case Reports, 5:11;1847-1851, 2017.

0570D005

Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.

- 89 -

0575

Department of Gastroenterological Endoscopy

Faculty
Title

Name

Field of Specialization

Professor

ITO Tohru

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer

Professor

URASHIMA Sachio

Diagnosis for esophagus, Hepato-biliary-pancreatic treatment

Associate Professor

Senior Assistant Professor

Senior Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAWAURA Ken
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KOBAYASHI Rika
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAMAI Junji
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Original
0575B001

K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selectionof Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on thePatients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.

- 90 -

Presentations at Conference
International Conference (Key Note Lecture)
0575G001

T.Ito:Standard Endoscopy Diagnosis & Treatment of Early Gastric Cancer in Japan, The 19th Japan-Russia
Endoscopy Symposium, ST PETERSBURG, 2017.

0575G002

T.Ito:Early Gastric Cancer Managiment:Japanese Experience, Yaroslavl Endoscopy Symposium 2017, Yaroslavl,
2017.

International Conference (Presentations)
0575I001

Tohru Itoh, Ken Kawaura, Kazu Hamada, Hidekazu Kitakata, Sadafumi Azukisawa, Rika.Kobayashi:Can the
Percutaneous Endoscopic Gastrostomy(PEG)become the untrition care to change oral, ENDO2017, Ｈｙｄｅｒａｂａｄ,2017.02.

- 91 -

0577

Department of Cardiovascular Intervention

Faculty
Title

Name

Field of Specialization

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Associate Professor

TSUCHIYA Taketsugu

Assistant Professor

KITAGAWA Katsuhide

Publications
Originals
0577B001

Kamioka Norihiko, Soga Yoshimitsu, Kuramitsu Shoichi, Iida Osamu, Hirano Keisuke, Suzuki Kenji, Kawasaki
Daizo, Yamaoka Terutoshi, Suematsu Nobuhiro, Shintani Yoshiaki, Miyashita Yusuke, Takahashi Hiroki, Tsuchiya
Taketsugu, Shinozaki Norihiko, Okazaki Shinya, Ando Kenji:Clinical outcomes of balloon angioplasty alone versus
nitinol stent implantation in patients with small femoropopliteal artery disease: Observations from theRetrospective Multicenter Analysis for Femoropopliteal Stenting (REAL-FP)., Catheterization and cardiovascularinterventions, 90:5;790-797, 2017.

0577B002(K.Suzuki), Y.Mizutani, Y.Soga, O.Iida, D.Kawasaki, Y.Yamauchi, K.Hirano, R.Koshida, D.Kamoi, J.Tazaki,
M.Higashitani, Y.Shintani, T.Yamaoka, S.Okazaki, N.Suematsu, T.Tsuchiya, Y.Miyashita, N.Shinozaki,
H.Takahashi, N.Inoue:Efficacy and Safety of Endovascular Therapy for Aortoiliac TASC D Lesions., Angiology,
68:1;67-73, 2017.

0577B003

M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa , R.Saito, H.Aoki, K.Fujibayashi,
T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severityof coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.

0577B004

Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao
Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density
lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.

0577B005

Soga Yoshimitsu, Takahara Mitsuyoshi, Iida Osamu, Yamauchi Yasutaka, Hirano Keisuke, Fukunaga Masashi, Zen
Kan, Suzuki Kenji, Shintani Yoshiaki, Miyashita Yusuke, Tsuchiya Taketsugu, Yamaoka Terutoshi, Ando Kenji:
Efficacy of CilostAzol for Below-the-Knee Artery Disease after Balloon AnGioplasty in PatiEnts with Severe Limb
Ischemia (CABBAGE Trial)., Annals of vascular surgery, 45:22-28, 2017.

- 92 -

0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

MATSUMOTO Gouichi Bone Regeneration, Biomaterials, Oral Cancer

Associate Professor

ISHIBASHI Hiroaki

Oral tumor, Oral Pathology

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Senior Assistant Professor

KATO Takao

Oral cavity, Kampo medicines, Dental pharmacology

Assistant Professor

KATO Koichiro

Oral tumor

Assistant Professor

HASUMOTO Miho

Orthodontics

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery, kampo medicines, dental pharmacology

Outline of Research
1. Basic and clinical research for disorders of temporomandibular joins.
2. Molecular biological research for growth and metastasis of tumors in oral region.
3. Pathophysiological research for abnormal development of oral and maxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central nervous systems.
6. Studies on the pharmacological mechanism of Kampo medicine.

Books
0580A001(Hiroshi Sakagami), Takao Kato, Kunihiko Fukuchi, Taisei Kanamoto, Shigemi Terakubo, Hideki Nakashima,
Hirokazu Ohno, Masaji Yamamoto:Applicability of Licorice Extracts for Treatment of Oral Diseases, Evaluated by
Simplified In Vitro Assay Systems with Oral Cells, Biological Activities and Action Mechanisms of Licorice
Ingredients (Hiroshi.Sakagami), 91-106, InTech, Croatia, 2017.

Publications
Originals
0580B001(Naotoshi Sugimoto), Hiroaki Ishibashi, Hiroyuki Nakamura, Akihiro Yachie, Takako Ohno-shosaku:Hypoxiainduced inhibition of the endocannabinoid system in glioblastoma cells, Oncology Reports, 38:3702-3708, 2017.

Case Reports
0580D001

Noboru.Demura, Miho.Hasumoto, Taichi.Demura:A Case of Orthodontic Treatment for a Patient with Occlusal
Abnormality Due to Epileptic Seizure, Journal of Dental and Oral Health, 3:090, 2017.

0580D002

Natsuki Segami:A Case of Ameloblastoma Recurred 25 Years after Surgery, Journal of Dentistry and Oral Biology,
2:1085, 2017.

- 93 -

Presentations at Conference
International Conference (Key Note Lecture)
0580G001

Hiroaki Ishibashi:Inhibition of Acute Inflammation by Gene Therapy after Implant Placement, The 8th Conferenceof Asian International Association of Dental Traumatology, Bangkok, 2017.11.

- 94 -

0590

Department of Regenerative Medicine

Faculty
Title

Name

Field of Specialization

Professor

SHIMODAIRA
Shigetaka

Regenerative Medicine

Assistant Professor

KOYA Terutsugu

Regenerative Medicine

Keywords of Research
Dendritic cell-based vaccination, Cancer immunotherapy, Regenerative medicine using adipose tissue-derived stem cells,
Genomic medicine

Outline of Research
Researchers of the Department of Regenerative Medicine are spearheading the era of personalized medicine by developing
treatments that harness the power of immune cells and stem cells.
•Clinical investigation using dendritic cell-based cancer vaccines in accordance with the Good Gene, Cellular, and Tissuebased Products Manufacturing Practice (GCTP) standards•Contribution to the development of regenerative medicine technology using adipose tissue-derive stem cells•Genomic Regenerative Medicine

Publications
Originals
0590B001

Terutsugu Koya, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Shigetaka Shimodaira:Interferon-α-inducible
Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas LIgand Pathway-mediated Killer Activity,
SCIENTIFIC REPORTS, 7:42145, 2017.

0590B002

Koido S, Okamoto M , Kobayashi M, Shimodaira S, Sugiyama H:Significance of Wilms tumor 1 antigen as a canser
vaccine for pancreatic cancer, Discovery Medicine, 130:41-49, 2017.

Case Reports
0590D001

Sakai K, Shimodaira S, Maejima S, Sano K, Higuchi Y, Koya T, Sugiyama H, Hongo K:Clinical effect andimmunological response in patients with advanced malignant glioma treated with WT1-pulsed dendritic cell-based
immunotherapy: A report of two cases., Interdisciplinary Neurosurgery, 9:24-29, 2017.

Presentations at Conference
International Conference (Presentations)
0590I001

Terutsugu Koya, Shigetaka Shimodaira:IFN-α inducible dendritic cells matured with OK-432 exhibit professional
antigen-presentation and anti-tumor activity, 5th Annual Meeting of the International Cytokine & Interferon
Society, Kanazawa, 2017.10.

- 95 -

School of Nursing

8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Nursing education , Nursing skills

Professor

TAKIUTI Takako

Nursing history, Nursing skill

Associate Professor

MATSUI Yuko

Nursing skill

Senior Assistant Professor

SUGIMORI Chiyoko

Nursing skill

Assistant Professor

OKAYAMA Miki

Patient education for diabetes

Assistant Professor

MIYANAGA Aiko

Wound Care Nursing, Nursing skills

Keywords of Researchfundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care

Outline of Research
1. Verification of nursing skills
2. Study of nursing education

Publications
Originals
8010B001(Maiko Oya), Ryoko Murayama, Makoto Oe, Koichi Yabunaka, Hidenori Tanabe, Toshiaki Takahashi, Yuko Matsui,
Eiko Otomo, Chieko Komiyama, Hiromi Sanada:Continuous thermographic observation may predict extravasationin chemotherapy-treated patients, European Journal of Oncology Nursing, 28:56-61, 2017.

8010B002

Aiko Miyanaga:Transient Vascularization Promotes Proliferation and Cartilage-formation of Perichondrial
Progenitor Cells, 42:1;24-31, 2017.

8010B003

Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, MichikoMichibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of thepredictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.

- 96 -

8040

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

YANO Keiko

Matenity Nursing, Midwifery

Senior Assistant Professor

BODA Hitomi

Matenity Nursing，Midwifery

Senior Assistant Professor

IWATANI Kumiko

Matenity Nursing，Midwifery

Senior Assistant Professor

YAMAZAKI Chisato

Maternity Nursing, Midwifery

Keywords of Research
Practice, Pregnancy, Midwife, Maternity Nursing, perinatal, after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation, Dioxin

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care,
Dioxin.

Presentations at Conference
International Conference (Presentations)
8040I001

K.Iwatani, K.Shimada, K.Kanamori, M.Izuhara, S.Yoshida:Analysis of the causes and strategies for preventing
incidents occurring during skilled birth attendant training using an RCA approach, 20th East Asian Forum of
Nursing Scholars, Hong Kong, 2017.

8040I002

Chisato Yamazaki:Challenges of clinical recordings using electronic partograms in Japan, 31st ICM Triennial
Congress, Toronto, 2017.06.

8040I003

Keiko Yano, Maya Okuda, Sanfa Shin3, Xenia Fukuda, Yuki Mori, Kyoka Yuraku, Yoko Natsuyama, Rumi
Okamoto, Yumi Kanbara,Chiharu Sugiyama, Mitsuyo Taniguchi:Implementation and Effectiveness of Adolescent
Education Peer Support for University Students as Carried Out by Midwife Students, 31st ICM Triennial Congress,
Toronto, 2017.

- 97 -

8050

Pediatric Nursing

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

HASHI Shinobu

Single mother, asthma, child, belief, parenting stress

Assistant Professor

TERAI Takahiro

Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Assistant Professor

ISHII Kazumi

personal hygiene care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment,

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention- 98 -

8060

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Professor

OBATA Mitsuko

Critical care

Associate Professor

MURAKADO Naoko

Chronic nursing，Diabetes nursing

Senior Assistant Professor

KINOSHITA Sachiko

Wound Care, Stoma care, Continence care

Senior Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

ASANO Kimi

Wound Care

Assistant Professor

Natsuko Yamada

Critical Care

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care, Critical Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8060B001(Tamae Urai), Kimi Asano, Yukari Nakajima, Kanae Mukai, Toshio Nakatani:Effectiveness of using an ostomy skinbarrier/wafer as a splint to maintain the shapes of circular cutaneous wounds in obese mice, 15:2;57-61, 2017.

8060B002

Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, MichikoMichibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of thepredictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.

Reviews
8060C001

Chizuko Konya, Mizuho Endo, Junko Sugama:Improving the quality of care for peristomal skin disorders using
information and communications technology, Journal of Nursing Science and Engineering, 4:1;15-20, 2017.

Presentations at Conference
International Conference (Presentations)
8060I001(E.Hirayama), Y.Kitamura:The nurses' structure of concern when providing care to patients who have been
informed about cancer recurrence or metastasis in Japan, 14th Annual AAPINA National Conference, Honolulu,
2017.

- 99 -

8070

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Professor

HIRAMATSU Tomoko community/elderly nursing science

Associate Professor

KOIZUMI Yumi

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8070B001

Morita Takuro, Okuno Tazuo, Himeno Taroh, Watanabe Keisuke, Nakajima Kumie, Koizumi Yumi, Yano Hiroshi,
Iritani Osamu, Okuro Masashi, Morimoto Shigeto:Glycemic control and disability-free survival in hypoglycemic
agent-treated community-dwelling older patients with type 2 diabetes mellitus., Geriatrics & gerontology
international, 17:1858-1865, 2017.

8070B002(Shizuko Omote), Arisu Watanabe, Tomoko Hiramatsu, Emiko Saito, Masami Yokogawa, Rie Okamoto, Chiaki
Sakakibara, Akie Ichimori, Kaoru Kyota, Keiko Tsukasaki:A foot-care program to facilitate self-care by theelderly: a non-randomized intervention study, intervention study BMC Research Notes, 10:586, 2017.

Case Reports
8070D001

Tomoe Hashimoto, Yumi Koizumi, Yoko Iwamoto, Tomoko Hiramatsu:Analysis of nursing sutudent's report inexperiential exercises for learning among elderly people with dementia, Journal of Japanese Society for Dementia
Care, 15:4;848-856, 2017.

Short Communications
8070E001

Tomoe Hashimoto, Kazuyo Kawasima:Investigation into the Actual Conditions of Bathing Care System in Longterm Care Facilities, Journal of Japan Academy of Gerontological Nursing, 22:1;115-122, 2017.

- 100 -

8080

Public Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Senior Assistant Professor

IKEUCHI Satomi

public health nursing

Senior Assistant Professor

NAKADA Yukari

public health nursing

School hygiene

Industrial health

Keywords of Research
Public health nursing-care activity, Public health nursing education, Health promotion, activity of cmmunity organization,
Non-smoking education, School hygiene, Industrial health,Outline of Research
The Public Health nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, part of a drug abuse prevention
program for junior high school student and health maintenance.

Presentations at Conference
International Conference (Presentations)
8080I001(Yusuke Kurebayashi), Satomi Ikeuchi, Aiko Hamada:Does self-focus differ between psychiatric and general
nurses? A cross-sectional study, The 20th EAFONS, Hong Kong, 2017.

8080I002(Tomomi Goda), Satomi Ikeuchi, Yusuke Kurebayashi, Aiko Hamada, Toshiyuki Kihara:The State of Career Support
Needs for New Faculty Members for Nursing Programs in Universities in Japan, The3th Conference on Public
Health in Asia, Hiroshima, 2017.

8080I003

Satomi Ikeuchi, Tomomi Goda, Yusuke Kurebayashi, Aiko Hamada, Toshiyuki Kihara:Fundamental Capabilities of
New Faculty Members for Nursing Programs, The3th Conference on Public Health in Asia, Hiroshima, 2017.

8080I004（Yusuke Kurebayashi）,Tomomi Goda, Satomi Ikeuchi , Aiko Hamada, Toshiyuki Kihara:Differences in Perceived
Need for Sappot Among New Nursing Teachers Working in aJapanese Nursing College Based on the Years ofExperience, The3th Conference on Public Health in Asia, Hiroshima, 2017.04.

- 101 -

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

FUKASAWA Yuko

Mental health, Psychiatric Nursing

Senior Assistant Professor

TANAKA Koji

Senior Assistant Professor

NAGAYAMA Yutaka

Assistant Professor

ARAI Satomi

life-world led care, patient-nurse interrelationship, empathy,
psychiatric and mental health nursing
Reducing the use of coercive measures, Strength-based nursing forpsychiatric patients
Mental health nursing, Concordance

Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship,
empathy, psychiatric and mental health nursing, reducing the use of coercive measures, physical restraint, seclusion,
Strengths model, Emotion Modulation Therapy

Outline of Research
The purpose of our study is to clarify the suicide prevention effect for the depression people by Narrative approach andEmotion Modulation Therapy(EMT). We are trｙing the effect of these methods as new therapeutic nursing for depression
people between our nursing clinic in Japan and Griffth University clinic in Australia.

Presentations at Conference
International Conference (Key Note Lecture)
8085G001

Tanaka.K:Trauma and Recovery, The 8th Joint scientific Meeting 2017 between KMU and HUST-TMC, Wuhan,
2017.

- 102 -

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
supportAssistant Professor

NAKAI Hisao

Home healthcare,Disaster Nursing,Care Management

Assistant Professor

FUKUDA Moriyoshi

Nursing care of pressure uler，Home care

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program, Psychiatric Disorder, Community besed Workshop, Recoverry"consept

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced Recoverry"consept prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Presentations at Conference
International Conference (Presentations)
8090I001

Y Kohno, S Sakurai:Relationship between impulses and stress when providing daily care among care workers
working in group homes in Japan, The 20th EAFONS, Hong Kong, 2017.

- 103 -

8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Kojima/electromagnetic radiation, M.
Kojima/ultraviolet exposure, M. Kojima/infrared rays exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.
K. Iwai:Role of the nuclear matrix associated proteins in the regulation of gene expression of the cardiovascular cells.
Y.Morikawa:Epidemiology of work related disease, Social epidemiology

Publications
Originals
8100B001(Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, TeruhikoKido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin,
insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental andclinical endocrinology & diabetes, 125:1;12-20, 2017.

8100B002

M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse,
K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body massindex and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.

8100B003

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

Presentations at Conference
International Conference (Symposium)
8100H001

Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.

- 104 -

International Conference (Presentations)
8100I001

Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi
Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-yearchange of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.

8100I002

Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi
Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.05.

8100I003

Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo,
Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.05.

8100I004(Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J. Chakarothai, Kensuke Sasaki,
Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage
induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.

8100I005

Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORTTERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.

8100I006

Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.12.

8100I007

Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami
Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.12.

- 105 -

Department of General Education

8610

Natural Sciences

Faculty
Title

Name

Field of Specialization

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Associate Professor

HASHIMOTO
Mitsumasa

Radiation Biology, Cell Biology

Associate Professor

IIDA Yasuo

Function algebra,Function space

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Senior Assistant Professor

OKUDA Koichi

Fixed-quantity rating system in the heart nuclear medicine

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

INOUE Tomoki

Graph theory in toplogy

Keywords of Research
Bertrand curveMannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic fieldMannheim
curve, Frenet frame, graph theory in topology, topological polyhedron, , Nuclear medicine Nuclear cardiology, Imaging,
Image processingSPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing Radiation, DNA double strand breaks (DSBs),
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2), , ultrastructure,pharynxspongemetamorphosis, immunoelectron microscopy, neurosynapsneurosecretory cell, lectin, galectinβ-galactoside,
Xenopusdevelopment, placenta

Outline of Research
1)Functional analysis of Galectins a family of ・-galactosides binding proteins. a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
Hashimoto:Function of DNA repair enzymes especially protection mechanisms against DNA double strand breaks induced
ionizing radiation especially protection mechanisms against DNA double strand breaks induced ionizing radiation
Okuda:The aim of our research is to develop a computer algorithm for the quantitative assessment of myocardial perfusionand sympathetic nerve activity in the nuclear cardiology.
Inoue:We extend the Graph Theory and define a topologicalpolyhedron which coverd on closed surface of genus g. We give
characterizations and example of the topological polyhedron.
MAEDA:Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies
have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.Further investigation of thedetails of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer.

Publications
Originals
8610B001

Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo,
Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patientswith idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.

8610B002

Okuda Koichi, Nakajima Kenichi, Kikuchi Akihiro, Onoguchi Masahisa, Hashimoto Mitsumasa:Cardiac and
Respiratory Motion-induced Artifact in Myocardial Perfusion SPECT, Annals of Nuclear Cardiology, 3:1;88-93,
2017.

- 106 -

8610B003(Nakajima Kenichi), Kudo Takashi, Nakata Tomoaki, Kiso Keisuke, Kasai Tokuo, Taniguchi Yasuyo, Matsuo
Shinro, Momose Mitsuru, Nakagawa Masayasu, Sarai Masayoshi, Hida Satoshi, Tanaka Hirokazu, Yokoyama
Kunihiko, Okuda Koichi, Edenbrandt Lars:Diagnostic accuracy of an artificial neural network compared withstatistical quantitation of myocardial perfusion images: a Japanese multicenter study., European journal of nuclear
medicine and molecular imaging, 44:13;2280-2289, 2017.

8610B004(Kenichi Nakajima), Koichi Okuda:123I-meta-iodobenzylguanidine Sympathetic Nerve Function Indices Derived
from Planar Images, Annals of Nuclear Cardiology, 3:1;200-202, 2017.

8610B005

Konishi Takahiro, Nakajima Kenichi, Okuda Koichi, Yoneyama Hiroto, Matsuo Shinro, Shibutani Takayuki,
Onoguchi Masahisa, Kinuya Seigo:IQ-SPECT for thallium-201 myocardial perfusion imaging: effect of normal
databases on quantification., Annals of nuclear medicine, 31:6;454-461, 2017.

8610B006

Okuda Koichi, Nakajima Kenichi:Normal Values and Gender Differences of Left Ventricular Functional Parameterswith CardioREPO Software, Annals of Nuclear Cardiology, 3:1;29-33, 2017.

8610B007Yoneyama Hiroto, Shibutani Takayuki, Konishi Takahiro, Mizutani Asuka, Hashimoto Ryosuke, Onoguchi
Masahisa, Okuda Koichi, Matsuo Shinro, Nakajima Kenichi, Kinuya Seigo:Validation of the Left Ventricular
Ejection Fraction with the IQ•SPECT System in Small-Heart Patients., Journal of nuclear medicine technology,
45:3;201-207, 2017.

8610B008

Okuda Koichi, Nakajima Kenichi, Matsuo Shinro, Kashiwaya Soichiro, Yoneyama Hiroto, Shibutani Takayuki,
Onoguchi Masahisa, Hashimoto Mitsumasa, Kinuya Seigo:Comparison of diagnostic performance of four software
packages for phase dyssynchrony analysis in gated myocardial perfusion SPECT, EJNMMI RESEARCH, 7:27, 2017.

8610B009(Nakajima Kenichi), Okuda Koichi, Matsuo Shinro, Kiso Keisuke, Kinuya Seigo, Garcia Ernest V:Comparison ofphase dyssynchrony analysis using gated myocardial perfusion imaging with four software programs: Based on theJapanese Society of Nuclear Medicine working group normal database, JOURNAL OF NUCLEAR CARDIOLOGY,
24:2;611-621, 2017.

8610B010

Yoneyama Hiroto, Nakajima Kenichi, Okuda Koichi, Matsuo Shinro, Onoguchi Masahisa, Kinuya Seigo, Edenbrandt
Lars:Reducing the small-heart effect in pediatric gated myocardial perfusion single-photon emission computed
tomography, JOURNAL OF NUCLEAR CARDIOLOGY, 24:4;1378-1388, 2017.

8610B011

Yasuo Iida:Bounded Subsets of Classes Mp(X) of Holomorphic Functions, Journal of Function Spaces,
2017:7260602, 2017.

8610B012(Nakajima Kenichi), Okuda Koichi, Yokoyama Kunihiko,Yoneyama Tatsuya, Tsuji Shiro, Oda Hiroyuki, Yoshita
Mitsuhiro, Kubota Koji:Cross calibration of I-123-meta-iodobenzylguanidine heart-to-mediastinum ratio with DSPECT planogram and Anger camera, ANNALS OF NUCLEAR MEDICINE, 31:8;605-615, 2017.

8610B013

Yasuo Iida:Bounded Subsets of Smirnov and Privalov Classes on the Upper Half Plane, International Journal of
Analysis, 2017:9134768, 2017.

Short Communications
8610E001(Nakajima Kenichi), Okuda Koichi;Verberne Hein J:Phase dyssynchrony and (123)I-meta-iodobenzylguanidine
innervation imaging towards standardization., Journal of nuclear cardiology : official publication of the American
Society of Nuclear Cardiology, 1-5, 2017.

Presentations at Conference
International Conference (Presentations)
8610I001

Hideaki Shiga, Junichi Taki, Koichi Okuda, Naoto Watanabe, Hisao Tonami, Seigo Kinuya, Takaki Miwa:
Correlation of thallium olfactory transport and olfactory bulb volume in patients with olfactory impairment after
upper respiratory infection, AChemS 39th Annual Meeting 2017, Florida, 2017.04.

- 107 -

8620

Human Sciences

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

HONDA Kojiro

Ethics of technology

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Associate Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Senior Assistant Professor

KIKUCHI Takeshi

Philosophy, ethics, philosophy, ethics and the education, research of
the thing supporting life, health, life, philosophy of the minority

Senior Assistant Professor

IKENAKA Masami

English Education

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishAssistant Professor

MURAKAMI Yusuke

adapted physical activity

Keywords of Research
exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE class, , end of the century,
culture, the middle Ages, Modern times, Europe, , articulatory phonetics, acoustic phonetics, English phonology, Japanesephonology, pronunciation, L2 researchlanguage acquisition, medical research article, novel, individualism, quest,
existentialism, Buildungsroman, humor, irony, narration, suffering, humanity cross-cultural differences, cultural variation,
NLP, Python programming language, medical Englishe-learning, , logic, metaphysics, form, content, predicate, category,
deduction, induction, matterbeing, substance, definion, Phenomenology, Philosophy of Technology, Ethics of Technology,
Engineering Ethics, Robo-ethics, Medical Ethics, Cognitive Science of Learning, History of Science, Philosophy of Science,

Outline of Research
Hara:In the German-language area from the end of the 19th century to the beginning of the 20th century many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe many prominent intellects appeared in various fields of culture. Hofmannsthal isalso one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna but his influence
reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extractthe essence of the modern culture in the German-language area and furthermore in all Europe.
Kouchi:Das Europa im zweiten Halfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen mittelalterlichnen
Denkweise zur neuen modernen wie sie der Historiker Reinharｔ Kosellecｋ die ？Sattelzeit“ nennt. Wie man sich damals
mit dem Wechsel des Paradigmas auseinander setzte mochte ich im Fall vom deutschen Dichter Goethe untersuchen und inseinen Werken wie Romanen und Dramen zeigen mochte ich im Fall vom deutschen Dichter Goethe untersuchen und inseinen Werken wie Romanen und Dramen zeigen
HONDA:It is inquiring about the ethics of technology. Tradition of knowledge" has considered the problem what kind of
responsibility occurs why in possible one and the side which inherits knowledge again by the mainly phenomenological
technique.
Shibuya:Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here Japanese) influence the pronunciation of- 108 -

Japanese speakers of English is studied, Japanese) influence the pronunciation of Japanese speakers of English is studied.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the English found in medical articles to determine themost commonly used words forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.
Tsuda:Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition our
research focuses on improvement of physical fitness through soccer in PE classes for children.

Publications
Originals
8620B001

Kojiro Honda:Neo-Luddism in the 21st century -AI will cause a new labor issue, 44:1-10, 2017.

Presentations at Conference
International Conference (Presentations)
8620I001

Ryosuke Tsuda:Results of a soccer teaching program intended to help students improve and acquire knowledge ofphysical fitness, The 22nd annual Congress of the European College of Sport Science (ECSS), Essen, 2017.

- 109 -

University Hospital

0675

Health Evaluation Center

Faculty
Title

Name

Field of Specialization

Professor

ASAJI Takayoshi

Heartfailure

Professor(Additional Post)

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

NAKANISHI Yumiko

Preventive medicine

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

KAWANAMI Haruka

Hematology and Immunology

Associate Professor(Additional Post)
Senior Assistant Professor(Additional Post)

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001(Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Nishijo Muneko, Hideaki Nakagawa, Yasushi Suwazono:Estimationof Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants ofan Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.

0675B002(Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, TeruhikoKido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin,
insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental andclinical endocrinology & diabetes, 125:1;12-20, 2017.

0675B003

M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse,
K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body massindex and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.

0675B004(Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le,
Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin
exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.

0675B005(Hirokazu Kakuda), Junji Kobayashi, Masaru Sakurai, Masahiro Kakuda, Noboru Takekoshi:The effect of
tofogliflozin treatment on postprandial glucose and lipid metabolism in Japanese men with type 2 diabetes: A pilot
study, Journal of clinical medicine research, 9:5;403-409, 2017.

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0675B006(Rie Oka), Kyoko Shibata, Masaru Sakurai, Mitsuhiro Kometani, Masakazu Yamagishi, Kenichi Yoshimura, Takashi
Yoneda:Trajectories of postload plasma glucose in the development of type 2 diabetes in Japanese adults, Journalof Diabetes Research, 2017:5307523, 2017.

0675B007(Toshinari Takamura), Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai,
Takeshi Urabe, Shuichi Kaneko:Weight-adjusted lean body mass and calf circumference are protective against
obesity-associated insulin resistance and metabolic abnormalities, Heliyon, 3:7;e00347, 2017.

0675B008

Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn,
Yoshikazu Nishino:Gender-Specific Impact of Cadmium Exposure on Bone Metabolism in Older People Living in a
Cadmium-Polluted Area in Thailand, International Journal of Envitronmental Research and Publich Health,
14:4;401, 2017.

0675B009

Yasufumi Masaki, Shoko Matsui, Takako Saeki, Hiroto Tsuboi, Shintaro Hirata, Yasumori Izumi, Taiichiro
Miyashita, Keita Fujikawa, Hiroaki Dobashi, Kentaro Susaki, Hisanori Morimoto, Kasutaka Takagi, Mitsuhiro
Kawano, Tomoki Origuchi, Yoko Wada, Naoki Takahashi, Masanobu Horikashi, Hiroshi Ogishima, Yasunori Suzuki,
Takafumi Kawanami, Haruka Kawanami-Iwao, Tomoyuki Sakai, Yoshimasa Fujita, Toshihiro Fukushima, Masatoshi
Saito, Ritsuro Suzuki, Yuko Morikawa, Tadashi Yoshino, Shigeo Nakamura, Masaru Kojima, Nozomu Kurose,
Yasuharu Sato, Yoshiya Tanaka, Susumu Sugai, Takayuki Sumida:A multicenter phase II prospective clinical trial of
glucocorticoid for patients with untreated IgG4-related disease, Modern Rheumatology, 27:5;849-854, 2017.

0675B010

Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death inpatients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of afollow-up study in Japan, BMJ Open, 7:7;e015694, 2017.

0675B011(Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira,Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura
Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels ofhigh-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology,
32:547-557, 2017.

0675B012(Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono:
Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.

0675B013

Takamura Taka-aki, Tsuchiya Taketsugu, Oda Minako, Watanabe Makoto, Saito Ryuhei, Sato-Ishida Ryoko, Akao
Hironobu, Kawai Yasuyuki, Kitayama Michihiko, Kajinami Kouji:Circulating malondialdehyde-modified low-density
lipoprotein (MDA-LDL) as a novel predictor of clinical outcome after endovascular therapy in patients with
peripheral artery disease (PAD), ATHEROSCLEROSIS, 263:192-197, 2017.

0675B014

K.Kawaura, T.Itoh, K.Hamada, H.Kitakata, S.Azukisawa, H.Okamura, S.Urashima, M.Sakurai, M.Ishizaki:Selectionof Methods for Percutaneous Endoscopic Gastrostomy(PEG)that is more Safety and Useful Techniques on thePatients., CLINICAL INVESTIGATION, 7:3;111-118, 2017.

0675B015(Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni,
Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le
Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.

0675B016(Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai
Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli
Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Nishijo Muneko, Kido Teruhiko,Tai Pham The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives, Epidemiology(Cambridge, Mass.), 28:Suppl 1;19-34, 2017.

0675B017

Hirokazu Kakuda, Junji Kobayashi, Masaru Sakurai, Noboru Takekoshi:The Effects of Tofogliflozin on Glucose
Metabolism and Uric Acid, Progress in Medicine, 37:10;1219-1223, 2017.

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Reviews
0675C001

Yasufumi Masaki, Shino Fujimoto, Haruka Kawanami (Iwao), Tomoyuki Sakai, Takafumi Kawanami, Yopshimasa
Fujita, Hiroshi Kawabata, Toshihiro Fukushima:The treatment strategy of IgG4-related disease - from the result ofprospective clinical study -, 29:2;140-146, 2017.

Presentations at Conference
International Conference (Presentations)
0675I001

Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi
Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-yearchange of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.

0675I002

M.Nishijo, H.Nakagawa, K.Nogawa, T.Suwazono, T.Kido:Cancer mortality of residents living in the cadmiumpolluted Jinzu River basin in Toyama,Japan, 14th International Conference on the Biogeochemistry of Trace
Elements, Zurich, 2017.07.

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Medical Research Institute7100

Department of Life Sciences

Faculty
Title

Name

Field of Specialization

Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor

IWAWAKI Takao

Cellular stress response

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

TASAKI Takafumi

Protein regulation by the post-translational modifications and its
underlying molecular mechanisms

Senior Assistant Professor

OHTSUKA Satoshi

Stem Cell Biology

Senior Assistant Professor

TANIGUCHI Makoto

Molecular and Cellular Biology, Lipid Biochemistry

Assistant Professor

TATSUNO Takanori

Molecular biology

Assistant Professor

HIRAMATSU
Nobuhiko

Molecular and Cellular Biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy, protein quality control, gene
expression control, homeostatic regulation, biological defense system, molecular imaging

Outline of Research
1.Study on viral replication and pathogenicity
2.Molecular mechanism of carcinogenesis and metastasis
3.Research on plolyploidization and polyploid cells
4.Analyses of transcription and mRNA decay
5.Protein regulation by the post-translational modifications and its underlying molecular mechanisms
6.Lipid metabolism and its-associated diseases
7.Stem cell biology and development
8.Physiologocal and pathological function of cellular stress response

Publications
Originals
7100B001(Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki , Yuka Nakamura, Managu Oguchi,
Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma, Annals of nuclear medicine, 31:590-595, 2017.

7100B002(Souichi Nukuzuma), Chiyoko Nukuzuma, Masanori Kameoka, Shigeki Sugiura, Kazuo Nakamichi, Takafumi Tasaki,
Tsutomu Takegami:CPT11 prevents virus replication in JCI cells persistently infected with JC polyomavirus.,
Microbiology and immunology, 61:6;232, 2017.

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7100B003(Tschurtschenthaler M), Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak
MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM,
Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A:Defective ATG16L1-mediated removalof IRE1α drives Crohn's disease-like ileitis, The Journal of Experimental Medicine, 214:2;401-422, 2017.

7100B004(Duran-Aniotz C), Cornejo VH, Espinoza S, Ardiles ÁO, Medinas DB, Salazar C, Foley A, Gajardo I, Thielen P,
Iwawaki T, Scheper W, Soto C, Palacios AG, Hoozemans JJM, Hetz C:IRE1 signaling exacerbates Alzheimer's
disease pathogenesis, Acta Neuropathologica, 134:489-506, 2017.

7100B005(Fink SL), Jayewickreme TR, Molony RD, Iwawaki T, Landis CS, Lindenbach BD, Iwasaki A:IRE1α promotes viral
infection by conferring resistance to apoptosis, Science Signaling, 10:eaai7814, 2017.

7100B006(Márquez S), Fernández JJ, Terán-Cabanillas E, Herrero C, Alonso S, Azogil A, Montero O, Iwawaki T, CubillosRuiz JR, Fernández N, Crespo MS:Endoplasmic Reticulum Stress Sensor IRE1α Enhances IL-23 Expression by
Human Dendritic Cells, Frontiers in Immunology, 8:639, 2017.

7100B007(Hiraoka H), Nakahara K, Kaneko Y, Akiyama S, Okuda K, Iwawaki T, Fujimura M, Kumagai Y, Takasugi N,
Uehara T:Modulation of Unfolded Protein Response by Methylmercury, Biological and Pharmaceutical Bulletin,
40:1595-1598, 2017.

7100B008(Oh S), Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T,
Yamamoto M, Shoda J:Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity
via redox modulation in skeletal muscles, Scientific Reports, 7:12902, 2017.

7100B009(Motegi SI), Sekiguchi A, Uchiyama A, Uehara A, Fujiwara C, Yamazaki S, Perera B, Nakamura H, Ogino S,
Yokoyama Y, Akai R, Iwawaki T, Ishikawa O:Protective effect of mesenchymal stem cells on the pressure ulcer
formation by the regulation of oxidative and endoplasmic reticulum stress, Scientific Reports, 7:17186, 2017.

7100B010(Forootan SS), Mutter FE, Kipar A, Iwawaki T, Francis B, Goldring CE, Park BK, Copple IM:Real-time in vivo
imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity,
Scientific Reports, 7:16084, 2017.

7100B011(Tavernier SJ), Osorio F, Vandersarren L, Vetters J, Vanlangenakker N, Van Isterdael G, Vergote K, De Rycke R,
Parthoens E, van de Laar L, Iwawaki T, Del Valle JR, Hu CA, Lambrecht BN, Janssens S:Regulated IRE1dependent mRNA decay sets the threshold for dendritic cell survival, Nature Cell Biology, 19:698-710, 2017.

7100B012

Iwawaki T, Akai R, Toyoshima T, Takeda N, Ishikawa T, Yamamura K:Transgenic mouse model for imaging of
ATF4 translational activation-related cellular stress responses in vivo, Scientific Reports, 7:46230, 2017.

7100B013

Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.

7100B014(Kaufman DR), Papillon J, Larose L, Iwawaki T, Cybulsky AV:Deletion of Inositol-Requiring Enzyme-1α in
Podocytes Disrupts Glomerular Capillary Integrity and Autophagy, Molecular Biology of the Cell, 28:12;16361651, 2017.

7100B015

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

7100B016

Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi
Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.

7100B017

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

Reviews
7100C001

Takao Iwawaki:Transgenic mouse models for molecular optical imaging in vivo, The Journal of Japan Society for
Laser Surgery and Medicine, 37:454-458, 2017.

7100C002

Takao Iwawaki:From property of IL-1β to imaging of inflammation, Japanese Journal of Clinical Immunology,
40:329-336, 2017.

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Presentations at Conference
International Conference (Key Note Lecture)
7100G001

Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2)
in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.

7100G002

Takafumi Tasaki:Molecular mechanism of the interaction between UBR4 and HPVE7, N-Term 2017, Halle,
2017.09.

International Conference (Presentations)
7100I001

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.

7100I002(Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J Chakarothai, Kensuke Sasaki,
Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage
induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.08.

7100I003(Saioa Márquez), José Javier Fernández, Eli Terán-Cabanillas, Carmen Herrero, Takao Iwawaki, Juan R CubillosRuiz, Nieves Fernández, Mariano Sánchez Crespo:Endoplasmic reticulum stress sensor IRE1α and PERK enhance
IL-23 expression by human dendritic cell, The 31st Annual Meeting of the European Macrophage and Dendritic
Cell Society, Madrid, 2017.09.

7100I004

Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORTTERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.

7100I005

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.

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7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TAKEUCHI Masayoshi AGEs, Lifestyle-related disease

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Associate Professor

NIIDA Yo

Genetic disease, Genetic diagnosis

Senior Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Assistant Professor

TAKATA Takanobu

AGEs, Biochemistry

Assistant Professor

SAKASAI Akiko

AGEs, Cell Biology

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype,

Outline of Research
1.Heart failure by autoimmune pathway related with G-protein
2.Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
3.The role of Toxic AGEs(TAGE) in the prevention of lifestyle related disease
4.Clinical research for the diagnosis and treatment of pancreatic cancer
5.Development and clinical application of fetal DNA diagnosis using mother’s blood
6.Genetic diagnosis and analysis of hereditary developmental disability
7.Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Publications
Originals
7200B001

Ippei Chikazawa, Shinya Inoue, Yusuke Nakazawa, Dan Nakai, Nobuyo Morita, Tatsuro Tanaka, Yoshiharu Motoo,
Katsuhito Miyazawa:Clinical study on the efficacy and continuous docetaxel based chemotherapy treatment for
castration-resistant prostate cancer, 63:9;351-357, 2017.

7200B002

S.Sakamoto, H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi,
A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.

7200B003

Keiko Yukawa, Hirono Ishikawa, Yoshihiko Yamazaki, Jimpei Misawa, Kiichiro Tsutani, Ichiro Arai, Yoshiharu
Motoo, Takahiro Kiuchi:Economic burden and mental distress in using complementary and alternative medicine,and formal supports by medical professional of japanese patients with chronic diseases, Japanese Pharmacology &Therapeutics, 45:3;345-355, 2017.

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7200B004

M.Watanabe, Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi,
T.Tsuchiya, H.Nakanishi, K.Saito, M.Takeuchi, K.Kajinami:Diurnal glycemic fluctuation is associated with severityof coronary artery disease in prediabetic patients: Possible role of nitrotyrosine and glyceraldehyde-derived
advanced glycation end products., Journal of cardiology, 69:4;625-631, 2017.

7200B005

Y Motoo, T Hakamatsuka, N Kawahara, I AraiI, K Tsutani:Standards of reporting Kampo products (STORK) in
research articles, Journal of Integrative Medicine, 15:3;182-185, 2017.

7200B006(Jun-ichi Takino), Kentaro Nagamine, Mikoto Suzuki, Akiko Sakasai-Sakai, Masayoshi Takeuchi, Takamitsu
Hori:Gene Expression Changes Associated with the Loss of Heterogeneous Nuclear Ribonucleoprotein M Function,
American Journal of Molecular Biology, 7:87-98, 2017.

7200B007(Tahara Atsuko), Tahara Nobuhiro, Yamagishi Sho-ichi, Honda Akihiro, Igata Sachiyo, Nitta Yoshikazu, Bekki
Munehisa, Nakamura Tomohisa, Sugiyama Yoichi, Sun Jiahui, Takeuchi Masayoshi, Shimizu Makiko, Yamazaki
Hiroshi, Fukami Kei, Fukumoto Yoshihiro:Ratio of serum levels of AGEs to soluble RAGE is correlated withtrimethylamine-N-oxide in non-diabetic subjects, INTERNATIONAL JOURNAL OF FOOD SCIENCES AND
NUTRITION, 68:8;1013-1020, 2017.

7200B008

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

7200B00(Sannohe Takahiro), Ohnuma Tohru, Takeuchi Masayoshi, Tani Eriko, Miki Yasue, Takeda Mayu, Katsuta
Narimasa, Takebayashi Yuto, Nakamura Toru, Nishimon Shohei, Kimoto Ayako, Higashiyama Ryoko, Shibata
Nobuto, Gohda Tomohito, Suzuki Yusuke, Yamagishi Sho-Ichi, Tomino Yasuhiko, Arai Heii:High doses ofantipsychotic polypharmacy are related to an increase in serum levels of pentosidine in patients withschizophrenia., Progress in Neuro-Psychopharmacology & Biological Psychiatry, 76:42-48, 2017.

7200B010

Takanobu Takata, Tadashi Ueda, Akiko Sakasai-Sakai, Masayoshi Takeuchi:Generation of glyceraldehyde-derived
advanced glycation end-products in pancreatic cancer cells and the potential of tumor promotion, World Journal of
Gastroenterology, 23:4910-4919, 2017.

7200B011

Bo Ryosuke, Yamada Kenji, Kobayashi Hironori, Jamiyan Purevsuren, Hasegawa Yuki, Taketani Takeshi, Fukuda
Seiji, Hata Ikue, Niida Yo, Shigematsu Yosuke, Iijima Kazumoto, Yamaguchi Seiji:Clinical and molecularinvestigation of 14 Japanese patients with complete TFP deficiency: a comparison with Caucasian cases, JOURNAL
OF HUMAN GENETICS, 62:9;809-814, 2017.

7200B012(Suzuki Toshiaki), Yamamoto Ayano, Ohsawa Masahiro, Motoo Yoshiharu, Mizukami Hajime, Makino Toshiaki:
Effect of ninjin'yoeito and ginseng extracts on oxaliplatin-induced neuropathies in mice, Journal of Natural
Medicines, 71:4;757-764, 2017.

7200B013

Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Masayoshi Takeuchi:Impact of intracellularglyceraldehyde-derived advanced glycation end-products on human hepatocyte cell death, Scientific Reports,
7:14282, 2017.

7200B014

Yuko Matsui, Ryoko Murayama, Hidenori Tanabe, Makoto Oe, Yoshiharu Motoo, Takanori Wagatsuma, MichikoMichibuchi, Sachiko Kinosita, Keiko Sakai, Chizuko Konya, Junko Sugama, Hiromi Sanada:Evaluation of thepredictive validity of thermography in identifying extravasation with intravenous chemotherapy infusions, Journal of
Infusion Nursing, 40:6;367-374, 2017.

7200B015(Hori Eisei), Kikuchi Chigusa, Nagami Chie, Kajikuri Junko, Itoh Takeo, Takeuchi Masayoshi, Matsunaga Tamihide:
Role of Glyceraldehyde-Derived AGEs and Mitochondria in Superoxide Production in Femoral Artery of OLETF
Rat and Effects of Pravastatin, BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40:11;1903-1908, 2017.

7200B016

Toshio Ohnishi, Chieko Hashizume, Makoto Taniguchi, Hidehiro Furumoto, Jia Han, Rongfen Gao, Shinichi
Kinami, Takeo Kosaka, Toshiro Okazaki:Sphingomyelin synthase 2 deficiency inhibits the induction of murine
colitis-associated colon cancer, The Faseb Journal, 31:9;3816-3830, 2017.

7200B017(Kita Kenji), Arai Sachiko, Nishiyama Akihiro, Taniguchi Hirokazu, Fukuda Koji, Wang Rong, Yamada Tadaaki,
Takeuchi Shinji, Tange Shoichiro, Tajima Atsushi, Nakada Mitsutoshi, Yasumoto Kazuo, Motoo Yoshiharu,
Murakami Takashi, Yano Seiji:In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy oftargeted drugs, Cancer Medicine, 6:12;2972-2983, 2017.

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7200B018

Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi
Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki:
Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.

Reviews
7200C001

Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata:Involvement of toxic AGEs(TAGE) in the onset /progrssion of nonalcoholic fatty liver disease (NAFLD): A novel prevention strategy, 23:20-30, 2017.

7200C002

Masayoshi Takeuchi, Jun-ichi Takino, Akiko Sakasai-Sakai, Takanobu Takata, Mikihiro Tsutsumi:Toxic AGE(TAGE) Theory for the Pathophysiology of the Onset/Progression of NAFLD and ALD, Nutrients, 9:634-, 2017.

7200C004

Yoshiharu Motoo:Gastrointestinal adverse effects and their management in molecular targeting therapy, Nippon
Rinsho, 75:9;1425-1429, 2017.

Case Reports
7200D001

Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hairhypoplasia associated with isolated hypoganglionosis: A case report, CONGENITAL ANOMALIES, 57:1;32-34,
2017.

7200D002

Niida Yo, Mitani Yusuke, Kuroda Mondo, Yokoi Ayano, Nakagawa Hiroyasu, Kato Akiko:A Say-Barber-BieseckerYoung-Simpson variant of Ohdo syndrome with a KAT6B 10-base pair palindromic duplication: A recurrent
mutation causing a severe phenotype mixed with genitopatellar syndrome, CONGENITAL ANOMALIES, 57:3;8688, 2017.

7200D003

Nobuhiko Ueda, Yoritaka Fujii, Seiko Miura, Jun Fujita, Yasuto Tomita, Toshio Ohnishi, Hideto Fujita, Shinichi
Kinami, Kazuhiko Omote, Yasuharu Nakano, Takeo Kosaka, Yoshiharu Motoo:Long-term survival due tocombination therapy in a patient with locally advanced body-tall pancreatic cancer, Japanese Journal of Cancer andChemotherapy, 44:12;1373-1375, 2017.

Short Communications
7200E001

Niida Yo, Yokoi Ayano, Kuroda Mondo, Mitani Yusuke, Nakagawa Hiroyasu, Ozaki Mamoru:Reply to: Uniparental
disomy of chromosome 1 unmasks recessive mutations of PPT1 in a boy with neuronal ceroid lipofuscinosis type 1,
BRAIN & DEVELOPMENT, 39:2;184-185, 2017.

7200E002(Yokota Mami), Sekita Marie, Okano Yuri, Masaki Hitoshi, Takeuchi Masayoshi, Tokudome Yoshihiro:
Glyceraldehyde-Derived Advanced Glycation End Products Accumulate Faster Than N-epsilon-(Carboxymethyl)
Lysine, ANNALS OF DERMATOLOGY, 29:4;508-511, 2017.

Presentations at Conference
International Conference (Key Note Lecture)
7200G001

Toshiro Okazaki:Inhibition of acute colitis and hepatic infiltration malignant cells by SMS2 deficiency, Key notespeaker at 8th international Ceramide Conference, New York, 2017.05.

7200G002

Toshiro Okazaki, Chieko Hashizume, Makoto Taniguchi, Takeo Kosaka:Role of sphingomyeline synthase 2 (SMS2)
in murine colitis and colon cancer, 3rd International Conference on New Horizons of Basic nd Applied Science,
Hurghada, 2017.08.

7200G003

Toshiro Okazaki:Ceramid increase by deficiency of sphingomyelin synthase (SMS) 2 suppressed murine acute colitis
and colon cancer initiation through cytokine/chemokine inhibition, Bioactive Lipids in Cancer,Inflammation&Related Diseases, 15th international conference, Puerto Vallarta, Mexico, 2017.10.

International Conference (Symposium)
7200H001

Y Motoo:Standards of Reporting Kampo Products (STORK) in research articles., The 4th International Symposiumof Japanese Kampo Medicine (ISJKM), Berlin, 2017.05.

7200H002

Y Motoo:Chemotherapy Support Team (CST) and Kampo, 12th International Congress of Complementary Medicine
and Research (ICCMR), Berlin, 2017.05.

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International Conference (Presentations)
7200I001

Yo Niida, Mamoru Ozaki:Mutational Analysis of TSC1 and TSC2 in Japanese Patients with Tuberous Sclerosis
Complex, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.

7200I002

Tomiyasu Arisawa, Hikaru Takano, Tasuku Hayashi, Wu Jing, Masafumi Ota, Tomoe Nomura, Ranji Hayashi,
Toshimi Otsuka, Takeo Shimasaki, Masakatsu Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATIONIN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.

7200I003

Hitoshi Sato, Atsushi Ishii, Chisato Akita, Kanju Ikeno, Yo Niida, Sawako Yamazaki, Shinichi Hirose, Hiroaki
Kakinuma, Yutaka Saikawa:A case with severe recurrent attacks of hemiplegic migraine mimicking acuteencephalopathy, 14th Asian and Oceanian Congress of Child Neurology, Fukuoka, 2017.05.

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7310

Division of Innovative Research

Title

Name

Field of Specialization

Professor(Additional Post)

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, Enviromental health sciences,
Epidemiology of cadmium pollution

Faculty

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products,

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. Cellular and molecular mechanisms in angiogenesis

Publications
Originals
7310B001(Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono:Estimationof Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants ofan Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.

7310B002(Amartuvshin Bor), Muneko Nishijo, Hiroshi Nishimaru, Tomoya Nakamura, Nghi Ngoc Tran, Quang Van Le,
Yusaku Takamura, Jumpei Matsumoto, Yoshikazu Nishino, Hisao Nishijo:Effects of high fat diet and perinatal dioxin
exposure on development of body size and expression of platelet-derived growth factor receptor beta in the rat
brain, Journal of Intergrative Neuroscience, 16:4;453-470, 2017.

7310B003

Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Journal of Cell Science, 130:5;916-926, 2017.

7310B004

Muneko Nishijo, Kowit Nambunmee, Dhitiwass Suvagandha, Witaya Swaddiwudhipong, Werawan Ruangyuttikarn,
Yoshikazu Nishino: Gender-specific impact of cadmium exposure on bone metabolism in older people living in a
cadmium-polluted area in Thailand, International Journal of Envitronmental Research and Publich Health, 14:4;401,
2017.

7310B005

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

7310B006

Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death inpatients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of afollow-up study in Japan, BMJ Open, 7:7;e015694, 2017.

7310B007(Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni,
Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le
Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.

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7310B008(Kishi Reiko), Zhang Jun Jim, Ha Eun-Hee, Chen Pau-Chung, Tian Ying, Xia Yankai, Tsuchiya Kenji J, Nakai
Kunihiko, Kim Sungkyoon, Hong Soo-Jong, Hong Yun-Chul, Lee Jeong-Rim, Jan Mohamed Hamid Jan B, Parajuli
Rajendra Prasad, Adair Linda S, Chong Yap Seng, Guo Yue Leon, Wang Shu-Li, Muneko Nishijo, Kido Teruhiko,Tai Pham-The, Nandasena Sumal:Birth Cohort Consortium of Asia: Current and Future Perspectives,
Epidemiology (Cambridge, Mass.), 28:Suppl 1;19-34, 2017.

Presentations at Conference
International Conference (Presentations)
7310I001

Muneko Nishijo, Hideaki Nakagawa, Kazuhiro Nogawa, Yasushi, Suwazono, Teruhiko Kido:Cancer mortality ofresidents living in the cadmium-polluted Jinzu River basin in Toyama,Japan, 14th International Conference on the
Biogeochemistry of Trace Elements, Zurich, 2017.07.

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7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

FUKUDA Masamichi

ocular pharmacology, intraocular, penetration

Associate Professor(Additional Post)
Assistant Professor(Additional Post)

HATSUSAKA Natsuko ophthalmological optics

Keywords of Research
electromagnetic waves, ultraviolet rays, radioactive rays, cataract, pterygium, pinguecula.

Outline of ResearchThis research division studies environmental effects on incidence of ocular diseases. In quantitative studies of radio
frequency (RF) electromagnetic spectrum effects on eyes, ocular effects from exposure to wavelengths encountered in daily
life are examined by experimentation on rabbit eyes. Research on ocular exposure to ultraviolet (UV) wavelengths utilizes ahuman like mannequin equipped with UV sensors, and evaluates the efficacy of sunglasses, eye glasses and otheraccessories in offering eye protection against harmful exposure.
Our longitudinal epidemiological studies on eyes in Japan (Ishikawa) and Iceland, epidemiological surveys on blindness and
UV-related eye disease in Tanzania, and ocular epidemiological studies in domestic and international regions with different
climate conditions were conducted to investigate and analyze associations among ocular UV exposure and cataract,pterygium, and pinguecula. In our epidemiological study on UV-related ocular diseases targeting Japanese and Taiwanesechildren, the effects of ocular UV exposure in childhood are examined.
In 2013, a longitudinal study on radiation exposure dose and incidence of lens opacity in emergency workers of TEPCO
Fukushima Daiichi Nuclear Power Plant was commenced and is envisaged to include approximately 20,000 subjects.

Publications
Originals
7320B001(Noriaki Nagai), Yu Mano, Hiroko Otake, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Amyloid β1-43 Accumulates inthe Lens Epithelium of Cortical Opacification in Japanese Patients, Investigative Ophthalmology & Visual Science,
58:3294-3302, 2017.

7320B002

Hiroshi Sasaki:Primary and secondary preventions of cataracts, Rinsho Ganka, 71:1;52-60, 2017.

7320B003(Noriaki Nagai), Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:A positive feedback loop between nitricoxide and amyloid β(1-42) accelerates mitochondrial damage in human lens epithelial cells, Toxicology, 381:1930, 2017.

7320B004

E.Kubo, S.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, Dhirendra P.Singh:FGF2 antagonizes aberrant TGFβ
regulation of tropomyosin: role for posterior capsule opacity., Journal of Cellular and Molecular Medicine,
21:5;916-928, 2017.

7320B005(Koji Kitazawa), Chie Sotozono, Noriko Koizumi, Kenji Nagata, Tsutomu Inatomi, Hiroshi Sasaki, Shigeru
Kinoshita:Safety of anterior chamber paracentesis using a 30-gauge needle integrated with a specially designed
disposable pipette, British Journal Of Ophthalmology, 101:548-550, 2017.

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7320B006(Norihiro Mita), Hiroshi Sasaki, Kazutaka Kani, Akio Tabuchi, Heihachiro Hara:Multiple comparisons in two-factor
testing of psychophysical thresholds by the delta test method, Communications in statistics-simulation andcomputation, 46:1;669-678, 2017.

7320B007

Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P. Singh:Sulforaphane reactivates cellularantioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, Scientific reports,
7:14130, 2017.

7320B008(Toshiyuki Hayashida), Hiroshi Sasaki, Nobuyuki Hamada, Hideo Tatsuzaki, Natsuko Hatsusaka, Keiichi Akahane,
Sumi Yokoyama:Issues behind Radiation Management of Workers at Fukushima Nuclear Power Plant of Tokyo
Electric Power Company -From the Viewpoint of Radiation Exposure of the Ocular Lens and the Biological Effects
to the Lens-, Japanese Journal of Health Physics, 52:2;88-99, 2017.

Case Reports
7320D001

Nobuyuki Fujita, Teppei Shibata, Masamichi Fukuda, Kazuyuki Sasaki, Hiroshi Sasaki:An ease with successfultreatment of the endogenous endophthalmitis caused by Streptococcus anginosus endocarditis, Folia Japanica deOphthalmologica Clinica, 10:12;1007-1010, 2017.

Presentations at Conference
International Conference (Symposium)
7320H001

Masami Kojima:Acute ocular injuries caused by 40, 75, 95 GHz millimeter wave exposure, BioEM, Hangzhou,
2017.

International Conference (Presentations)
7320I001

Hiroshi Sasaki, Natsuko Hatsusaka, Hisanori Miyashita, Naoko Shibata, Yusuke Seki, Teppei Shibata, Hiromi
Osada, Hidetoshi Ishida, Masami Kojima Eri Kubo:Crystalline lens change peculiar to diabetes, The Association for
Research in Vision and Ophthalmology, Baltimore, 2017.

7320I002

Hisanori Miyashita, Natsuko Hatsusaka, Yusuke Seki, Aya Nakano, Masami Kojima, Yutaka Kawakami, Eri Kubo,
Hiroshi Sasaki:Influence of ocular UV exposure on risk of cataract in Chinese, The Association for Research in
Vision and Ophthalmology, Baltimore, 2017.

7320I003

Eri Kubo, Shinsuke Shibata, Teppei Shibata, Naoki Tanimura, Dhirendra P. Singh, Hiroshi Sasaki:FGF2-mediatedinduction of microRNA29c and its regulation of Tropomyosin, The Association for Research in Vision andOphthalmology, Baltimore, 2017.

7320I004

Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Naoki Tanimura, Hiroshi Sasaki, Eri Kubo:Effects ofproteoglycan decorin on lens epithelial cells, The Association for Research in Vision and Ophthalmology,
Baltimore, 2017.

7320I005

Naoko Shibata, Shinsuke Shibata, Teppei Shibata, Etsuko Kiyokawa, Hiroshi Sasaki, Eri Kubo:Comparison of gene
expression profiles in human pterygium and UV-induced gene expressions in human conjunctival epithelium, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.

7320I006

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.

7320I007

Hidetoshi Ishida, Norihiro Mita, Eri Kubo, Mai Kita, Aya Nakano, Yuuki Ukai, Ayako Okamoto, Naoko Shibata, Eri
Kubo, Hiroshi Sasaki:Comparison of the postoperative stability of the three types of single-piece intraocularlenses, The Association for Research in Vision and Ophthalmology, Baltimore, 2017.

7320I008

Eri Shibuya, Mai Sasaki, Norihiro Mita, Ayako Okamoto, Mai Kita, Hiromi Osada, Naoko Shibata, Yoriko
Takahashi, Eri Kubo, Hiroshi Sasaki:Posterior capsular wrinkle in eyes with 2 types of 1-piece intraocular lens,
The Association for Research in Vision and Ophthalmology, Baltimore, 2017.

7320I009(Bhavana Chhunchha), Eri Kubo, Hiroshi Sasaki, Dhirendra P. Singh:Switching of redox signaling by sulforaphane
determines lens epithelial cells fate by hormetic mechanisms involving Prdx6/Nrf2 and Klf9 pathways, The
Association for Research in Vision and Ophthalmology, Baltimore, 2017.

- 123 -

7320I010(Yukihisa Suzuki), Masami Kojima, Maya Mizuno,Tsutomu Okuno, Masao Taki, J. Chakarothai, Kensuke Sasaki,
Kanako Wake, Souichi Watanabe, Hiroshi Sasaki:Estimation of the thresholds for corneal epithelium damage
induced by millimeter-wave electromagnetic field exposure with a mathematical model based on CEM43℃
criterion, 32nd URSI GASS, Montreal, 2017.

7320I011

Takafumi Tasaki, Masami Kojima, Yukihisa Suzuki, Yoshinori Tatematsu, Hiroshi Sasaki:CREATING A SHORTTERM STABLE ENVIRONMENT FOR RABBITS IN A CARGO VAN, 68th AALAS National Meeting, Austin,
2017.10.

7320I012

Hiroshi Sasaki, Ayako Okamoto, Naoko Shibata, Eri Shibuya, Norihiro Mita, Hidetoshi Ishida, Eri Kubo:Influence
on toric intraocular lems axis by incision misalignment:a simulation study, European Society of Cataract &Refractive Surgens, Lisbon, 2017.

7320I013

Masami Kojima, Yukihisa Suzuki, Kensuke Sasaki, Hiroshi Sasaki:Microwave radiation cataract, International
Conference on the Lens, Kona, 2017.

7320I014

Hisanori Miyashita, Natsuko Hatsusaka, Hiromi Osada, Teppei Shibata, Yusuke Seki, Yutaka Kawakami, Masami
Kojima, Eri Kubo, Hiroshi Sasaki:Risk of five types of cataract in eyes with pseudoexfoliation syndrome,
International Conference on the Lens, Kona, 2017.

7320I015

Shinsuke Shibata, Naoko Shibata, Teppei Shibata, Hiroshi Sasaki, Eri Kubo:Expression of decorin, and its relation
to posterior capsular opacification, International Conference on the Lens, kona, 2017.

7320I016

Natsuko Hatsusaka, Hisanori Miyashita, Naoki Tanimura, Yoshikazu Nishino, Eri Kubo, Hiroshi Sasaki:Ocular UV
exposure and cataract risk in highly myopic eyes, International Conference on the Lens, Kona, 2017.

7320I017

Norihiro Mita, Aya Nakano, Yuuki Ukai, Ayako Takayama, Eri Shibuya, Mai Kita, Hiromi Osada, Hisanori
Miyashita, Teppei Shibata, Eri Kubo, Hiroshi Sasaki:Anayusis of transparent lens formation in mid-and old-age byanterior segment OCT, International Conference on the Lens, Kona, 2017.

7320I018

Eri Kubo, Bhavana Chhunchha, Prerna Singh, Hiroshi Sasaki, Dhirendra P Singh:Sulforaphane reactivates cellularantioxidant defense by inducing Nrf2/ARE/Prdx6 activity during aging and oxidative stress, International
Conference on the Lens, Kona, 2017.

7320I019

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.

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7340

Division of Anticipatory Molecular Food Science and Technology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOYA Daisuke

diabetes, hypertension, obesity, aging

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Associate Professor(Additional Post)
Associate Professor(Additional Post)

Books
7340A001

Daisuke Koya:Capter3 Patient assessment and diagnosis, Managing diabetic nephropathies in clinical practice, 4756, Adis, Cham, 2017.

Publications
Originals
7340B001(Yasuhiro Onogi), Tsutomu Wada, Chie Kamiya, Kento Inata, Takatoshi Matsuzawa, Yuka Inaba, Kumi Kimura,
Hiroshi Inoue, Seiji Yamamoto, Yoko Ishii, Daisuke Koya, Hiroshi Tsuneki, Masakiyo Sasahara, Toshiyasu Sasaoka:
PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced
Obesity., Diabetes, 66:4;1008-1021, 2017.

7340B002(Shigehiro Katayama), Daishiro Yamada, Mikihiro Nakayama, Takashi Yamada, Masafumi Myoishi, Masaharu Kato,
Christina Nowack, Peter Kolkhof, Yoshimitsu Yamasaki, on behalf of the ARTS-DN Japan Study Group:A
randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus anddiabetic nephropathy, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 31:4;758-765, 2017.

7340B003

Hiroki Ito, Atsushi Nakagawa, Daisuke Koya:Reduced incretin effect in type 2 diabetes is mainly attributable toimpaired glucose responsiveness of β-cells: evaluation via an oral sugar load under a hyperglycemic clamp, Journalof Kanazawa Medical University, 42:1;7-16, 2017.

7340B004

Norikazu Ueki, Keizo Kanasaki, Megumi Kanasaki, Satoru Takeda, Daisuke Koya:Catechol-O-Methyltransferase
Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II., Hypertension, 69:6;11561164, 2017.

7340B005

Munehiro Kitada, Shin-ichi Tsuda, Kazunori Konishi, Ai Takeda-Watanabe, Mizue Fujii, Keizo Kanasaki, Makoto
Nishizawa, Atsushi Nakagawa, Daisuke Koya:Anagliptin ameliorates albuminuria and urinary liver-type fatty acidbinding protein excretion in patients with type 2 diabetes with nephropathy in a glucose-lowering-independent
manner., BMJ open diabetes research & care, 5:1;e000391, 2017.

7340B006

Jinpeng Li, Sen Shi, Swayam Prakash Srivastava, Munehiro Kitada, Takako Nagai, Kyoko Nitta, Miyuki Kohno,
Keizo Kanasaki, Daisuke Koya:FGFR1 is critical for the anti-endothelial mesenchymal transition effect of Nacetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway, CELL DEATH & DISEASE, 8:e2965,
2017.

7340B007

Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu
Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya:Deficiency in catechol-omethyltransferase is linked to a disruption of glucose homeostasis in mice, SCIENTIFIC REPORTS, 7:1;7927,
2017.

7340B008

Munehiro Kitada, Yoshio Ogura, Hiroko Maruki-Uchida, Masahiko Sai, Taeko Suzuki, Keizo Kanasaki, Yuna Hara,
Hiromi Seto, Yuka Kuroshima, Itaru Monno, Daisuke Koya:The Effect of Piceatannol from Passion Fruit (Passiflora
edulis) Seeds on Metabolic Health in Humans, NUTRIENTS, 9:10;1142, 2017.

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7340B009(Per-Henrik Groop), Mark E Cooper, Vlado Perkovic, Berthold Hocher, Keizo Kanasaki, Masakazu Haneda,
Guntram Schernthaner, Kumar Sharma, Robert C Stanton, Robert Toto, Jessica Cescutti, Maud Gordat, Thomas
Meinicke, Audrey Koitka-Weber, Sandra Thiemann, Maximilian von Eynatten:Linagliptin and its effects on
hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINAT2D trial, DIABETES OBESITY & METABOLISM, 19:11;1610-1619, 2017.

7340B010

Munehiro Kitada, Yoshio Ogura, Taeko Suzuki, Itaru Monnno, Keizo Kanasaki, Ai Watanabe, Daisuke Koya:Cyclic
and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar
fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity, NEPHROLOGY, 22:12;1030-1034, 2017.

7340B011(Tsutomu Wada), Akari Ishikawa, Eri Watanabe, Yuto Nakamura, Yusuke Aruga, Hayate Hasegawa, Yasuhiro
Onogi, Hiroe Honda, Yoshinori Nagai, Kiyoshi Takatsu, Yoko Ishii, Masakiyo Sasahara, Daisuke Koya, Hiroshi
Tsuneki, Toshiyasu Sasaoka:Eplerenone prevented obesity-induced inflammasome activation and glucose
intolerance, JOURNAL OF ENDOCRINOLOGY, 235:3;179-191, 2017.

Reviews
7340C001

Yuta Takagaki, Daisuke Koya, Keizo Kanasaki:Dipeptidyl peptidase-4 inhibition and renoprotection: the role ofantifibrotic effects, CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 26:1;56-66, 2017.

7340C002

Munehiro Kitada, Yoshio Ogura, Itaru Monno, Daisuke Koya:Regulating Autophagy as a Therapeutic Target for
Diabetic Nephropathy., Current diabetes reports, 17:7;53, 2017.

7340C003

Keizo Kanasaki:DKD in elderly population, 75:11;1724-1732, 2017.

Short Communications
7340E001

Daisuke Koya:Impact of empagliflozin on diabetic kidney disease, JOURNAL OF DIABETES INVESTIGATION,
8:5;658-660, 2017.

Presentations at Conference
International Conference (Key Note Lecture)
7340G001

Daisuke Koya:Luseogliflozin in T2DM manegement, Diabetes Asia 2017, Kuala Lumpur, 2017.10.

International Conference (Symposium)
7340H001

Yuta Takagaki, Keizo Kanasaki, Makoto Kato, Daisuke Koya:Dipeptidyl peptidase-4 plays a pathogenic role in
BSA-induced kidney injury in diabetic mice, 2017 Asia Islet Biology & Incretin Symposium (AASD AffiliatedSymposium), Seoul, 2017.03.

7340H002

Keizo Kanasaki:Symposium II The pathological role of endothelial DPP-4 in diabetic kidney fibrosis, 2017 Asia Islet
Biology & Incretin Symposium (AASD Affiliated Symposium), Seoul, 2017.03.

7340H003

Daisuke Koya:Symposium 1 Autophagy & diabetes Autophagy protects against kidney injury related to aging,obesity and diabetes, 3rd Korea-Japan Diabetes Forum in conjunction with 30th Spring Congress of Korean
Diabetes Association, Busan, 2017.05.

7340H004

Daisuke Koya:Nutrition, inflammation & metabolism Beneficial effects of calorie restriction and protein dilution,
The 37th Annual Meeting of the Korean Society of Nephrology (KSN2017), Seoul, 2017.05.

7340H005

Daisuke Koya:Experience in diabetes management across countries A truly Asian real world evidence of SGLT2i,
Diabetes Asia 2017, Kuala Lumpur, 2017.10.

International Conference (Presentations)
7340I001

Y.Takagaki, S.M.Lee, D.Zha, K.Kanasaki, D.Koya:Atg5 deficiency in endothelial cells contributes to thedevelopment of IL-6 dependent endothelial to mesenchymal transition and kidney fibrosis, 53rd Annual Meeting of
the European Association for the Study of Diabetes (EASD 2017), Lisbon, 2017.

- 126 -

7340I002

O.Tachibana, Y.Hayashi, Y.Sasagawa, S.Takada, A.Tamase, S.Shiraga, K.Okamoto, A.Nakagawa, D.Koya,
M.Nakada, H. Iiduka:The efficacy of intra-operative topical dexamethasone administration on the prevention of
Rathke cleft cyst re-accumulation and recurrence, The 1st meeting of Japan-China Neurosurgery Alliance, The 9th
Neurosurgery Conference of China and Japan, Zhengzhou Dengfeng, 2017.11.

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7350

Division of Systems Bioscience for Drug Discovery Based on Intrinsically
Disordered Proteins

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)TOMOSUGI Naohisa

Clinical Proteomics

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Associate
Professor(Additional Post)SHIMASAKI Takeo

Medical Oncology, Gastroenterology, Bioinformatics

Publications
Originals
7350B001(Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi,
Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.

7350B002

S.Sakamoto, H.Kawabata, J.Kanda, T.Uchiyama, C.Mizumoto, T.Kitano, T.Kondo, M.Hishizawa, N.Tomosugi,
A.Takaori-Kondo:High pretransplant hepcidin levels are associated with poor overall survival and delayed platelet
engraftment after allogeneic hematopoietic stem cell transplantation., Cancer medicine, 6:1;120-128, 2017.

7350B003

Y.Yoshitomi, T.Ikeda, H.Saito, Y.Yoshitake, Y.Ishigaki, T.Hatta, N.Kato, H.Yonekura:JunB regulates angiogenesis
and neurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.

7350B004

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

7350B005

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

Reviews
7350C001

Arisawa Tomiyasu, Nakamura Masakatsu, Otsuka Toshimi, Jing Wu, Sakurai Naoko, Takano Hikaru, Hayashi
Tasuku, Ota Masafumi, Nomura Tomoe, Hayashi Ranji, Shimasaki Takeo, Tahara Tomomitsu, Shibata Tomoyuki:
Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative
colitis in Japan, WORLD JOURNAL OF GASTROENTEROLOGY, 23:29;5364-5370, 2017.

Presentations at Conference
International Conference (Presentations)
7350I001

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P. Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.

7350I002

Tomiyasu.Arisawa, Hikaru.Takano, Tasuku.Hayashi, Wu .Jing, Masafumi.Ota, Tomoe.Nomura, Ranji.Hayashi,
Toshimi.Otsuka, Takeo.Shimasaki, Masakatsu.Nakamura:THE PRE-MICRORNA938,TARGETING 1L-17L 3'UTR,GENE POLYMORPHISMS IS ASSOCIATED WITH THE RISK FOR DAP-KINASE HYPERMETHYLATIONIN HP INFECTED JAPANESE SUBJECTS, DDW2017, Chicago, 2017.05.

7350I003

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.

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7400

Research Support Center

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor

NAKAGAWA Hideaki

Senior AssistantProfessor(Additional Post)

MURAKAMI Manabu

Senior Assistant Professor

MIYAGOSHI Minoru

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine
Pathogenicity of flavivirus isolated from the field-collectedmosquitoes
Cell biology

Publications
Originals
7400B001(Keiko Kubo), Kazuhiro Nogawa, Teruhiko Kido, Nishijo Muneko, Hideaki Nakagawa, Yasushi Suwazono:Estimationof Benchmark Dose of Lifetime Cadmium Intake for Adverse Renal Effects Using Hybrid Approach in Inhabitants ofan Environmentally Exposed River Basin in Japan, Risk analysis : an official publication of the Society for Risk
Analysis, 37:1;20-26, 2017.

7400B002(Koshi Nakamura), Masaru Sakurai, Yuko Morikawa, Shin-ya Nagasawa, Katsuyuki Miura, Masao Ishizaki, TeruhikoKido, Yuchi Naruse, Motoko Nakashikma, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Serum ferritin,
insulin resistance, and β-cell dysfunction: a prospective study in normoglycemic Japanese men, Experimental andclinical endocrinology & diabetes, 125:1;12-20, 2017.

7400B003

M.Sakurai, K.Yoshita, K.Nakamura, K.Miura, T.Takamura, S-Y.Nagasawa, Y.Morikawa, T.Kido, Y.Naruse,
K.Nogawa, Y.Suwazono, S.Sasaki, M.Ishizaki, H.Nakagawa:Skipping breakfast and 5-year changes in body massindex and waist circumference in Japanese men and women, Obesity Science & Practice, 3:2;162-170, 2017.

7400B004

Shiga Hideaki, Taki Junichi, Okuda Koichi, Watanabe Naoto, Tonami Hisao, Nakagawa Hideaki, Kinuya Seigo,
Miwa Takaki:Prognostic value of olfactory nerve damage measured with thallium-based olfactory imaging in patientswith idiopathic olfactory dysfunction., Scientific reports, 7:1;3581, 2017.

7400B005

Tatsuya Koyama, Katsushi Yoshita, Nagako Okuda, Shigeyuki Saitoh, Kiyomi Sakata, Akira Okayama, Hideaki
Nakagawa, Naoko Miyagawa, Katsuyuki Miura, Queenie Chan, Paul Elliott, Jeremiah Stamler, Hirotsugu Ueshima:
Overall nutrient and total fat intake among Japanese people: The INTERLIPID Study Japan, Asia Pacific journal ofclinical nutrition, 26:5;837-848, 2017.

7400B006(Kotaro Higashi), Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi,
Tsutomu Takegami, Naoto Watanabe:High FDG uptake on PET is associated with negative cell-to-cell adhesion
molecule E-cadherin expression in lung adenocarcinoma., Annals of nuclear medicine, 31:590-595, 2017.

7400B007

Y.Yoshitomi,T.Ikeda,H.Saito,Y.Yoshitake,Y.Ishigaki,T.Hatta,N.Kato,H.Yonekura:JunB regulates angiogenesis andneurovascular parallel alignment in mouse embryonic skin, Jonal of Cell Science, 130:5;916-926, 2017.

7400B008

Yoichiro Hirakawa, Toshiharu Ninomiya, Yutaka Kiyohara, Yoshitaka Murakami, Shigeyuki Saitoh, Hideaki
Nakagawa, Akira Okayama, Akiko Tamakoshi, Kiyomi Sakata, Katsuyuki Miura, Hirotsugu Ueshima, Tomonori
Okamura, and the Evidence for Cardiovascular Prevention From Observational Cohorts in Japan Research Group(EPOCH-JAPAN):Age-specific impact of diabetes mellitus on the risk of cardiovascular mortality: An overview
from the evidence for Cardiovascular Prevention from Observational Cohorts in the Japan Research Group(EPOCH-JAPAN)., Journal of epidemiology, 27:3;123-129, 2017.

7400B009

Naohisa Tomosugi, Shoko Yamamoto, Masayoshi Takeuchi, Hideto Yonekura, Yasuhito Ishigaki, Noriaki Numata,
Shogo Katsuda, Yasuo Sakai:Effect of Collagen Tripeptide on Atherosclerosis in Healthy Humans, Journal of
Atherosclerosis and Thrombosis, 24:5;530-538, 2017.

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7400B010

Muneko Nishijo, Hideaki Nakagawa, Yasushi Suwazono, Kazuhiro Nogawa, Teruhiko Kido:Causes of death inpatients with Itai-itai disease suffering from severe chronic cadmium poisoning: a nested case-control analysis of afollow-up study in Japan, BMJ Open, 7:7;e015694, 2017.

7400B011

Murakami Manabu, Hori Kiyoe, Kitagawa Yoko, Oikawa Yosaburo, Kamimura Kiyoshi, Takagemi Tsutomu:An
Ecological Survey of Mosquitoes and the Distribution of Japanese Encephalitis Virus in Ishikawa Prefecture, Japan,
between 2010 and 2014, JAPANESE JOURNAL OF INFECTIOUS DISEASES, 70:4;362-367, 2017.

7400B012(Kazuhiro Nogawa), Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa, Yasushi Suwazono:
Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark
dose analysis, Journal of Applied Toxicology, 37:8;962-966, 2017.

7400B013(Hoang Duc Phuc), Teruhiko Kido, Nguyen Thi Phuong Oanh, Ho Dung Manh, Le Thai Anh, Yuko Oyama, Rie
Okamoto, Akie Ichimori, Kazuhiro Nogawa, Yasushi Suwazono, Hideaki Nakagawa:Effects of aging on cadmium
concentrations and renal dysfunction in inhabitants in cadmium-polluted regions in Japan., Journal of applied
toxicology, 37:9;1046-1052, 2017.

7400B014(Xian Liang Sun), Teruhiko Kido, Seijiro Honma, Eitetsu Koh, Rie Okamoto, Ho Dung Manh, Shoko Maruzeni,
Muneko Nishijo, Hideaki Nakagawa, Takeshi Nakano, Takumi Takasuga, Dang Duc Nhu, Nguyen Ngoc Hung, Le
Ke Son:The relationship between dioxins exposure and risk of prostate cancer with steroid hormone and age in
Vietnamese men, Science of the Total Environment, 595:842-848, 2017.

7400B015

Xiaohe Xu, Hisayoshi Yoshizaki, Yasuhito Ishigaki, Eri Kubo, Hiroshi Minato, Etsuko Kiyokawa:Upregulation ofmultiple signaling pathways by Dock5 deletion in epithelial cells, Molecular Vision, 23:1081-1092, 2017.

7400B016(Hirata Takumi), Sugiyama Daisuke, Nagasawa Shin-Ya, Murakami Yoshitaka, Saitoh Shigeyuki, Okayama Akira,Iso Hiroyasu, Irie Fujiko, Sairenchi Toshimi, Miyamoto Yoshihiro, Yamada Michiko, Ishikawa Shizukiyo, Miura
Katsuyuki, Ueshima Hirotsugu, Okamura Tomonori:A pooled analysis of the association of isolated low levels ofhigh-density lipoprotein cholesterol with cardiovascular mortality in Japan., European journal of epidemiology,
32:547-557, 2017.

7400B017

Le Thai Anh, Teruhiko Kido, Seijiro Honma, Ho Dung Manh, Ikue Koike, Yuko Oyama, Hoang Duc Phuc, Rie
Okamoto, Hideaki Nakagawa, Shoji F.Nakayama, Dang Duc Nhu, Nguyen Hung Minh, Ngo Van Toan, Le Ke Son:
A relationship in adrenal androgen levels between mothers and their children from a dioxin-exposed region in
Vietnam, The Science of the total environment, 607-608, 32-41, 2017.

7400B018

Nagako Okuda, Akira Okayam. Katsuyuki Miura, Katsushi Yoshita, Shigeyuki Saito, Hideaki Nakagawa, Kiyomi
Sakata, Naoko Miyagawa, Queenie Chan, Paul Elliott, Hirotsugu Ueshima, Jeremiah Stamler: Food sources of
dietary sodium in the Japanese adult population: the international study of macro-/micronutrients and bloodpressure (INTERMAP), European Journal of Nutrition, 56:3;1269-1280, 2017.

Presentations at Conference
International Conference (Presentations)
7400I001

Shinya Nagasawa, Katsuyuki Miura, Masaru Sakurai, Yuko Morikawa, Masao Ishizaki, Teruhiko Kido, Yasushi
Suwazono, Kazuhiro Nogawa, Hideaki Nakagawa:Longitudinal association between body weight change and 6-yearchange of blood pressure in Japanese men, EPI|LIFESTYLE2017, Portland, 2017.03.

7400I002

Teppei Shibata, Shinsuke Shibata, Hiroshi Sasaki, Dhirendra P Singh, Etsuko Kiyokawa, Masahito Ikawa, Yasuhito
Ishigaki, Eri Kubo:Tpm knockdown suppresses epithelial mesenchymal transition of lens epithelial cells, The
Association for Research in Vision and Ophthalmologu, Baltimore, 2017.05.

7400I003

M.Nishijo, H.Nakagawa, K.Nogawa, T.Suwazono, T.Kido:Cancer mortality of residents living in the cadmiumpolluted Jinzu River basin in Toyama,Japan, 14th International Conference on the Biogeochemistry of Trace
Elements, Zurich, 2017.07.

7400I004

Teppei Shibata, Shinsuke Shibata, Yasuhito Ishigaki, Etsuko Kiyokawa, Masahiko Ikawa, Dhirendra P Singh, Hiroshi
Sasaki, Eri Kubo:Konck-down of tropomyosin 2 created by CRISPR-CAS9 in mouse induced lens, International
Conference on the Lens, Kona, 2017.12.

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Himi Municipal Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

FUKUDA Akihiro

Cardiology

Professor

TOMIOKA Ryo

Neurology

Professor

KASAMAKI Yuji

General Medicine

Professor

MORIYAMA Manabu

Kidney transplantation，Urolithiasis

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Associate Professor

KIYOSAWA Jun

Cardiology

Senior Assistant Professor

SAITO Atsushi

Nephrology

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Associate Professor

IGUCHI Masaharu

Respiratory Medicine

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

HATANO Eiju

Spinal surgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

KOBATA Takashi

Cardiovascular Surgery

Senior Assistant Professor

TAGUCHI Keita

Orthopaedic surgery

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies

Assistant Professor

MIZUNO Takuro

Cardiology

Assistant Professor

YAMADA Shinya

Respiratory Medicine

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

SANGEN Ryusho

General Medicine

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

NAKAMURA Kisuke

Oncology Surgery

Assistant Professor

TAKAGI Sho

Cardiovascular Surgery

Assistant Professor

KUSABA Eizo

neurosurgery

Publications
Originals
9100B001

Masafumi Nojiri, Shiro Mizuno, Kazuaki Nishiki, Ryo Kato, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi,
Kazuhiro Osanai, Takeshi Ishizaki, Hirohisa Toga:ADRB2 gene polymorphism and emphysema heterogeneity canmodulate bronchodilator response in patients with emphysema, Pulmonary Pharmacology & Therapeutics,
48(2018):80-87, 2017.

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9100B002

Shiro Mizuno, Takeshi Ishizaki, Maiko Kadowaki, Masaya Akai, Kohei Shiozaki, Masaharu Iguchi, Taku Oikawa,
Ken Nakagawa, Kazuhiro Osanai, Hirohisa Toga, Jose Gomez-Arroyo, Donatas Kraskauskas, Carlyne D Cool,
Herman J Bogaard, Norbert F voelkel:p53 Signaling Pathway Polymorphisms Associated With Emphysematous
Changes in Patients With COPD, CHEST, 152:1;58-69, 2017.

Case Reports
9100D001

Mizuno Takuro, Kiyosawa Jun, Fukuda Akihiro, Watanabe Seiji, Kurose Nozomu, Nojima Takayuki, Kanda
Tsugiyasu:Infective endocarditis following tumor necrosis factor-α antagonist therapy for management of psoriatic
erythroderma: a case report., Journal of medical case reports, 11:1;35, 2017.

9100D002

Daisuke Usuda, Shinya Yamada, Kento Takeshima, Ryusho Sangen, Masaharu Iguchi, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma and Tsugiyasu Kanda:Gastroenteritis in Japanese Females Caused by Shigella flexneri
without Definite. Infection Route: A Case Report and Mini-Review of Literature, Journal Clinical Case Reports,
7:9;10001021, 2017.

9100D003

A.Takamura, R.Sangen, Y.Furumura, D.Usuda, Y.Kasamaki, T.Kanda:Diagnosis of myxedema coma complicated byrenal failure: a case report, Clinical Case Reports, 5:4;399-402, 2017.

9100D004

Daisuke Usuda, Masahisa Arahata, Kento Takeshima, Ryusho Sangen, Akiteru Takamura, Yasuhiro Kawai, Yuji
Kasamaki, Yoshitsugu Iinuma, Tsugiyasu Kanda:A Case of Diffuse Large B-Cell Lymphoma Mimicking Primary
Effusion Lymphoma-Like Lymphoma, Case Reports in Oncology, 10:1013-1022, 2017.

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