List of Poster Presentation on Day 1 (November 1 (Wed))
Poster Presentations

1P-01

Odd Numbers: November 1 (Wed) 13:35 - 14:20
Even Numbers: November 1 (Wed) 14:20 - 15:05

Preparation of nucleoside 3’-phosphate derivatives functionalized at 5’-position as
monomer units for novel strategies to oligonucleotide synthesis
Yoshiaki Kitamura*1,2,3, Risa Yamaguchi1, Natsuki Amano1
1Faculty of Engineering, Gifu University, 2United Graduate School of Drug Discovery and Medical Information

Sciences, Gifu University, 3Center for One Medicine Innovative Translational Research (COMIT), Gifu
University

1P-02

Stabilization of DNA Triplex using Novel Psoralen-Introduced Triplex-Forming
Oligonucleotides Enable the Induction of Stronger Cell Death of
Human Breast Cancer Cells
Haruki Toyama, Honoka Eshima, Juki Nakao, Yu Mikame*, Asako Yamayoshi*
Graduate School of Biomedical Sciences, Nagasaki University

1P-03

Analysis of the adduct formation of 2’-deoxyadenosine with glycidamide
Ryota Yamaguchi, Shigenori Iwai
Department of Chemistry, Graduate School of Engineering Science, Osaka University

1P-04

Synthesis and Enzymatic Incorporation of Fluorescent Thymidine Nucleotide Analogues
Tomotaka Kumagai1, Daisuke Hori1,2, Kenta Ishida4,5, Yuuya Kasahara4,5, Satoshi Obika4,5,6,
Hiroshi Sugiyama3, Soyoung Park*2
1Department of Chemistry, Graduate School of Science, Kyoto University, 2Immunology Frontier ResearchCenter (iFReC), Osaka University, 3Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University,
4Graduate School of Pharmaceutical Sciences, Osaka University, 5National Institutes of Biomedical
Innovation, Health and Nutrition (NIBIOHN), 6Institute for Open and Transdisciplinary Research Initiatives(OTRI), Osaka University

1P-05

Solid-Phase Synthesis of Oligodeoxynucleotides Using Nucleobase N-Unprotected
Oxazaphospholidine Derivatives Bearing a Long Alkyl Chain
Kiyoshi Kakuta, Ryota Kasahara, Kazuki Sato, Takeshi Wada*
Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science

1P-06

Chemical synthesis of oligonucleotides using 2’-O-vinyl RNA phosphoramidite units
Yuya Okawara, Ishin Ono, Yusuke Namiki, Kazushi Hisatsune, Kotaro Munakata,
Koichiro Miyauchi, Akihiro Ohkubo*
Department of Life Science and Technology, Tokyo Institute of Technology

1P-07

Synthesis and evaluation of (S)-5’-C-aminopropyl-2’- fluoro-modified nucleic acids for
siRNA therapeutics
Hitotaka Sato3, Yoshihito Ueno*1,2,3,4
1Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu

University, 2Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, 3United
Graduate School of Agricultural Science, Gifu University, 4Center for One Medicine Innovative Translational
Research (COMIT), Gifu University Institute for Advanced Study, Gifu University

1P-08

Construction of an artificial CO2 fixation compartment using DNA nanostructure
as a scaffold
Hui Yang1, Peng Lin1,2, Eiji Nakata1,2, Takashi Morii*1,2
1Graduate School of Energy Science, Kyoto University, 2Institute of Advanced Energy, Kyoto University

1P-09Strand invasion by PNA containing preQ1
Shun-suke Moriya1, Yosuke Demizu2, Masaaki Kurihara3, Atsushi Kittaka1, Toru Sugiyama*1
1Faculty of Pharma-Sciences, Teikyo University, 2Division of Organic Chemistry, National Institute of Health

Sciences, 3Faculty of Pharmaceutical Sciences, Shonan University of Medical Sciences

1P-10

Enhancement of gene expression level through 3’UTR conformational changes via
RNA hacking
Yua Itsuki1, Yousuke Katsuda*1,2, Yusuke Kitamura1, Toshihiro Ihara1
1Faculty of Advanced Science and Technology, Kumamoto University, 2StapleBio Inc.

1P-11

Large-scale analysis of nucleic acid-protein interactions by using photocatalyst-modified
nucleic acid
Ahmed Mostafa Abdelhady1, Kazumitsu Onizuka*1, Tatsuki Masuzawa2, Shinichi Sato3,
Keita Nakane3, Takanori Oyoshi2, Fumi Nagatsugi*1
1IMRAM, Tohoku University, 2Graduate School of Science and Technology, Shizuoka University, 3FRIS,

Tohoku University

1P-12

Regulation of photochemical 1O2 generation by conformational change ofartificial oligodeoxynucleotides
Sae Harada, Tatsuya Nishihara, Kazuhito Tanabe*College of Science and Engineering, Aoyama Gakuin University

1P-13

The Role of Loop Region in Folding Mechanism of DNA G-quadruplexes
Minori Nakata, Naoki Kosaka, Daisuke Miyoshi*
Graduate school of Frontiers of Innovative Research in Science and Technology, Konan University

1P-14

Elucidation of the regulatory mechanism of gene expression for new imperfectG-quadruplexes
Sunipa Sarkar1, Hisae Tateishi-Karimata1, Tatsuya Ohyama1, Naoki Sugimoto*1,2
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of

Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

1P-15

Allele Specific Quantitative PCR Using Chemically Modified Primers andProofreading Polymerases
Masayuki Fujii, Daichi Yano, Kana Inoue
Department of Biological & Environmental Chemistry, Faculty of Humanity Oriented Science andEngineering, Kindai University

1P-16

I-motif structure as a binding core for small fluorogens
Tamaki Endoh*1, Sinjan Das1, Shuntaro Takahashi1, Naoki Sugimoto*1,2
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of

Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

1P-17

High-throughput-based approach to comprehensively interrogate proximity-induced
RNA alkylation
Yutong Chen1,2, Kazumitsu Onizuka*1,2, Kaoru R. Komatsu3, Emi Miyashita3,4,
Hirohide Saito4, Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2Department of Chemistry,

Graduate School of Science, Tohoku University, 3FOREST Therapeutics, 4CiRA, Kyoto University

1P-18Preparation of 19F-labeled oligodeoxynucleotides and their application to detection of
miRNAs by 19F NMR
Yuki Hida, Tatsuya Nishihara, Kazuhito Tanabe*
Department of Science and Engineering, Graduate school of Science and Engineering, Aoyama Gakuin
University

1P-19

Development of Pyrimidine Structure-Based Alkylating Agents for Nucleic Acids
Modification
Ping-Yun Lan1,2, Kazumitsu Onizuka1,2, Yutong Chen1,2, Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University,

2Graduate School of

Science, Tohoku University

1P-20

Effects of Structure and Sequence on Liquid-Liquid Phase Separation of G4 Nucleic Acids
Sumit Shil, Mitsuki Tsuruta, Keiko Kawauchi, Daisuke Miyoshi*
Graduate school of Frontiers of Innovative Research in Science and Technology, Konan University

1P-21

Ultralow Background One-Pot Detection of Lead(II) Using a Non-Enzymatic Double-Cycle
System Mediated by a Hairpin-Involved DNAzyme
Ran An*1,2, Ting Yan1, Yuying Hou1, Qianqian Zuo1, Difei Jiang1, Huijie Zhao1, Tongyue Xia1,
Xiaoqian Zhu1, Xutiange Han1, Xingguo Liang1,2
1College of Food Science and Engineering, Ocean University of China, 2Laboratory for Marine Drugs andBioproducts, Pilot National Laboratory for Marine Science and Technology

1P-22

Investigation of important factor for efficient amplification by ab initio DNA synthesis
Yuka Kataoka, Chihiro Kubo, Tomoko Wariishi, Hiroto Fujita, Masayasu Kuwahara*
Graduate School of Integrated Basic Science, Nihon University

1P-23

Liquid-liquid phase separation of G-quadruplex is tuned by DNA cytosine methylation
Mitsuki Tsuruta1, Takeru Torii1, Keiko Kawauchi1, Naoki Sugimoto1,2, Daisuke Miyoshi*1
1Graduate school of Frontiers of Innovative Research in Science and Technology, Konan University, 2FrontierInstitute for Biomolecular Engineering Research, Konan University

1P-24

ROCKET: a Python tool to enhance in vitro transcription of short RNAs
Teppei Matsuda, Hiroyuki Hori1*, Ryota Yamagami*
Department of Applied Chemistry, Graduate School of Science and Engineering, Ehime University

1P-25

Development of a new oligonucleotide agent for site-specific RNA acetylation
Hirotaka Murase*1, Jeongsu Lee2, Yosuke Taniguchi3, Shuhei Imoto1, Shigeki Sasaki2
1Faculty of Pharmaceutical Sciences, Sojo University, 2Graduate School of Pharmaceutical Sciences,

Nagasaki International University, 3Graduate School of Pharmaceutical Sciences, Kyushu University

1P-26

Development of a post-elongation modification method of phosphate backbone based on
the amidation of phosphonoacetate-modified oligonucleotides
Daiki Fujisue1, Takashi Osawa1, Satoshi Obika*1,2
1Graduate School of Pharmaceutical Sciences, Osaka University, 2Institute for Open and Transdisciplinary

Research Initiatives, Osaka University

1P-27

Circularization of ssDNA without splint by formation of an intramolecular dynamic nickWenhua Sun1, Kunling Hu1, Ran An*1,2, Xingguo Liang*1,2
1College of Food Science and Engineering, Ocean University of China, 2Laboratory for Marine
Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology

1P-28

Precise control of catalytic reaction of T4 DNA ligase to stop at the adenylation stage via
dynamic nick formation
Kunling Hu1, Wenhua Sun1, Ziting Song1, Ran An1,2, Xingguo Liang*1,2
1College of Food Science and Engineering, Ocean University of China, 2Laboratory for Marine Drugs andBioproducts, Qingdao National Laboratory for Marine Science and Technology

1P-29Artificial Liposome Compartment with DNA Origami Scaffold for Size Exclusion MolecularTransport
Shiwei Zhang, Eiji Nakata, Peng Lin, Takashi Morii*
Institute of Advanced Energy, Kyoto University

1P-30

A Novel Regulation Method of mRNA Using RNA Stem-Loop Motif
Masayuki Fujii1, Yasuo Shiohama2
1Department of Biological & Environmental Chemistry, Faculty of Humanity Oriented Science andEngineering, Kindai University, 2Department of Organ Anatomy and Nanomedicine, Graduate School of
Medicine, Yamaguchi University

1P-31

Sequence-dependent effects on kinetic parameters of nucleic acid duplex formation
Elisa Tomita-Sudo1, Tomoka Akita2, Renshin Sano2, Ayumu Kashiwagi2, Junji Kawakami*1,2
1Konan Laboratory for Oligonucleotide Therapeutics, 2Department of Nanobiochemistry, FIRST, Konan

University

1P-32

Evaluation of APOBEC-catalyzed cytosine deamination for the repeat DNAs with binding
small molecules binding
Luyan Zhang1, Tomonori Shibata1, Asako Murata2, Kazuhiko Nakatani*1
1Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial

Research), Osaka University, 2Department of Material Scienses, Faculty of Engineering Sciences, Kyushu
University

1P-33

Sequences that destabilize DNA/RNA duplexes
Shizuka Közaki1,2, Ayumu Kashiwagi1, Shuichiro Fujiki1, Tomoka Akita1,2,
Junji Kawakami*1,2
1Department of Nanobiochemistry, FIRST, Konan University, 2Konan Laboratory for Oligonucleotide

Therapeutics (KOLOT)

1P-34

Twisting of i-motif DNA induced by diverse molecular crowdings
Shuntaro Takahashi*1, Saptarshi Ghosh1, Marko Trajkovski2, Pallavi Chilka1,
Tatsuya Ohyama1, Janez Plavec2, Naoki Sugimoto*1,3
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Slovenian NMR

Centre, National Institute of Chemistry, 3Graduate School of Frontiers of Innovative Research in Science andTechnology (FIRST), Konan University

1P-35

Temporal Control of Repeat RNA Phase Transitions Induced by Photoswitchable
RNA-binding Ligands
Yusuke Fujiwara1,2, Tomonori Shibata1,2, Chikara Dohno*1,2, Kazuhiko Nakatani*1,2
1SANKEN, Osaka University, 2JST, CREST

1P-36

Development of novel fluorescent indicators to discover new RNA-binding small moleculesin FID assay based on large-scale profiles of RNA-indicator interactions
Ryosuke Nagasawa1,2, Kazumitsu Onizuka1,2* Ryohei Iwata1,2, Kaoru R. Komatsu3,4,
Emi Miyashita3,4, Sayaka Dantsuji4, Hirotaka Murase1,2, Mamiko Ozawa1, Hirohide Saito3,
Fumi Nagatsugi*1,2
1IMRAM, Tohoku University, 2Department of Chemistry, Tohoku University, 3CiRA, Kyoto University,

4xFOREST therapeutics

1P-37

Interaction between fluoroquinolone derivative KG022 and RNAs: effect ofmodified nucleosides in the bulged residue
Rika Ichijo1, Takashi Kamimura2, Gota Kawai*1
1Chiba Institute of Technology, 2Veritas In silico Inc.

1P-38

Unusual topological RNA G-quadruplex formed by an RNA duplex:
implications for the dimerization of SARS-CoV-2 RNA
Shiyu Wang1, Yi Song1, Zhiyong He2, Hisao Saneyoshi1, Rie Iwakiri1, Pengyu Xu3,
Chuanqi Zhao4, Xiaogang Qu4,5, Yan Xu*1
1Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 2StateKey Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3Shonan
Laboratory, Corporate R&D Headquarters, Otsuka Chemical Co., Ltd., 4Laboratory of Chemical Biology andState Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese
Academy of Science, 5School of Applied Chemistry and Engineering, University of Science and Technology
of China

1P-39

Interaction between a small molecule, NA, and an RNA with the ACG/AUA internal loop
Aina Fujiwara1, Qingwen Chen2, Asako Murata3, Kazuhiko Nakatani2, Gota Kawai*1
1Department of Life Science, Faculty of Advanced Engineering, Chiba Institute of Technology, 2Department ofRegulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research, Osaka University,
3Department of Material Sciences, Faculty of Engineering Sciences, Kyushu University

1P-40

Development of new compounds using for gene detection
Fumie Takei*1, Naoki Yamada1, Sumiyo Hiruma1, Kaori Kamata1, Ichiro Yamashita2
1Faculty of Medicine, National Defense Medical College (NDMC), 2Graduate School of Engineering,Osaka University

1P-41

Regulation of gene expression by A-to-I RNA editing that occurs in the 5’ untranslated
region of mRNA
Yuki Ogata1, Shun Shimauchi1, Naoki Shimazu1, Masatora Fukuda*1,2
1Department of Chemistry, Graduate School of Science, Fukuoka University, 2Department of Chemistry,

Faculty of Science, Fukuoka University

1P-42

In Vitro Study of Aggregate Formation between CUG Repeat RNA and MBNL1 Protein
Surachada Chuaychob1,2, Wanqing Hou2, Musashi Shimizu2, Shun Nakano2,
Arivazhagan Rajendran1,2, Eiji Nakata1,2, Takashi Morii*1,2
1Integrated Research Center for Carbon Negative Science, Institute of Advanced Energy, Kyoto University,
2Institute of Advanced Energy, Kyoto University

1P-43

The methylated DNA changes the rate of strand displacement DNA polymerase
amplification
Mizuki Tomizawa, Kiwako Watanabe, Kaori Tsukakoshi, Wakako Tsugawa, Ryutaro Asano,Kazunori Ikebukuro*
Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University ofAgriculture and Technology

1P-44

Unveiling Atomic-Level Insights into the Influence of Molecular Crowding Environments on
Base-Pair Opening/Closing Dynamics in Parallel DNA Triplex Structures
Tomoki Sakamoto1,2, Yudai Yamaoki1,2, Takashi Nagata1,2, Masato Katahira*1,2
1Institute of Advanced Energy, Kyoto University, 2Graduate School of Energy Science, Kyoto University

1P-45

DNA major groove intercalation by a ruthenium(II) diiamine complex
Tayler D. Prieto Otoya1, Kane McQuaid1, Georgia Menounou2, Joseph Hennessy2,
Neil G. Paterson3, David J. Cardin1, Andrew Kellett2, Christine J. Cardin*1
1Department of Chemistry, University of Reading, 2School of Chemical Sciences, Dublin City University,
3Diamond Light Source Ltd.

1P-46

RNA Ligase Ribozymes with a Small Catalytic Core
Yoko Nomura, Yohei Yokobayashi*
Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate
University

1P-47

Directed Evolution of Group I Intron in Mammalian Cells
Tomoya Noma, Yohei Yokobayashi*
Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate
University

1P-48

Intracellular visualization of interaction between anti-miRNA oligonucleotide and its target
miRNA
Hongyu Zhu1, Yukiko Kamiya*1,2, Hiroyuki Asanuma*1
1Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, 2Laboratoryof Bioanalytical Chemistry, Kobe Pharmaceutical University

1P-49

Development of novel acyclic ESF nucleosides possessing flexible dihydroxypentyl
skeleton for target DNA detection
Satoru Yugami, Yurino Oku, Yosio Saito*
Graduate School of Engineering, Nihon University

1P-50

Programmable Macroscopic Self-Assembly of LNA-Decorated Shape-Controlled Hydrogel
BlocksBochen Zhu, Yohei Yokobayashi*
Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute of Science and Technology Graduate School

1P-51

Synthesis and Evaluation of Pyrrole－Imidazole Polyamide Conjugates with Pyridostatin
Analogues
Mitsuharu Ooga1, Toshikazu Bando*1, Hiroshi Sugiyama*2
1Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-

Material Science (WPI-iCeMS), Kyoto University

1P-52

Screening of DNA aptamers universally bind to single-chain variable fragment (scFv)
antibodies and the sensor application
Mai Hamasaki1, Shouhei Takamatsu1, Madoka Nagata2, Koji Sode2, Kazunori Ikebukuro1,
Ryutaro Asano*1,3
1Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University ofAgriculture and Technology, 2Joint Department of Biomedical Engineering, The University of North Carolina at
Chapel Hill and North Carolina State University, 3Institute of Global Innovation Research, Tokyo University ofAgriculture and Technology

1P-53

A new RNA platform for detecting a variety of biomolecules
Shunsuke Kawasaki*, Takeru Kuwabara, Hirohide Saito*
Center for iPS Cell Research and Application, Kyoto University

1P-54

Design of fluorine-containing ligands for enhancing the siRNA drug efficacy
Arisa Kagami1, Ai Kohata*1, Kohsuke Aikawa*1, Daisuke Kawaguchi1, Kunihiko Morihiro1,
Akimitsu Okamoto1, Takashi Okazoe2
1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo,
2AGC Inc. Yokohama Technical Center

1P-55

BIVID-MaP identifies allele-specific interaction between small-molecule and RNA structure
Emi Miyashita1,2, Kazumitsu Onizuka3, Yutong Chen3, Kaho Maeta2, Shunichi Kashida2,
Fumi Nagatsugi*3, Hirohide Saito*1, Kaoru R. Komatsu*2
1Center for iPS cells Research and Application, Kyoto University., 2xFOREST Therapeutics.,
3Institute of Multidisciplinary Research for Advanced Materials, Tohoku University

1P-56

Design of Cationized Gelatin Carriers for mRNA Delivery
Taichi Washisaka, Yasuhiko Tabata*
Institute for Life and Medical Sciences, Kyoto University

1P-57

Construction of DNA-Scaffolded Long-Range Intramolecular Energy Transmission System
Yuki Minamide, Koichi Tanimoto, Fumiaki Takano, Tomoya Niki, Shiori Tabana,
Akinori Kuzuya*
Department of Chemistry and Material Engineering Kansai University

1P-58

Diastereomeric Separation of Phosphorothioate-Modified Nucleic Acids Using
Polysaccharide-Based Chiral Columns Under Ion-Pair-Free Reversed-Phase Mode
Hideki Motoda*, Kanji Nagai, Takafumi Onishi, Atsushi Ohnishi*
Life Sciences R&D Center, PharmaTek BU, Life Sciences SBU, Daicel Corporation

List of Poster Presentation on Day 2 (November 2 (Thu))
Poster Presentations

2P-01

Odd Numbers: November 2 (Wed) 13:35 - 14:20
Even Numbers: November 2 (Wed) 14:20 - 15:05

Synthesis and Evaluation of 2’-Deoxycytidine Derivatives for the Recognition of 8-Oxo2’-deoxyguanosine in DNA
Yuta Chikada, Takato Sakurada, Ryo Miyahara, Yosuke Taniguchi*
Graduate School of Pharmaceutical Sciences Kyushu University

2P-02

Formation of formamidopyrimidine derivatives from the N7-adducts of 2’-deoxyguanosine
and analysis of their base pairing in duplexes
Tomohiro Baba, Shigenori Iwai
Department of Chemistry, Graduate School of Engineering Science, Osaka University

2P-03

One-Step Synthesis of Truncated Carbocyclic Nucleosides from Sugar-Derived
Julia-Kocienski Reagents
Natsuhisa Oka*1,2,3, Kei Sugiura1, Wakaba Arai1, Minami Furuzawa1, Mayuka Kanda1,
Kaori Ando1
1Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 2Institute for

Glyco-core Research (iGCORE), Gifu University, 3Center for One Medicine Innovative Translational
Research (COMIT), Gifu University

2P-04

Development of a method for chemical synthesis of long DNAs in a photolithographic
flow system
Koichiro Miyauchi, Teruyuki Okaniwa, Koki Maruyama, Ishin Ono, Tatsuhiro Yokoyama,
Aoma Yoshida, Akihiro Ohkubo*
School of Life Science and Technology, Tokyo Institute of Technology

2P-05

Chemically modified nucleosides enable reversible control of gene expression via
host-guest interaction
Takeyuki Yao1,2, Hidenori Okamura*1,2, Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2Graduate School of

Science, Tohoku University

2P-06

Orthogonal control of DNA duplex hybridization driven by host-guest interaction
Hidenori Okamura*1,2, Takeyuki Yao1,2, Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2Graduate School of

Science, Tohoku University

2P-07

Synthesis and enzymatic incorporation study of unnatural purine-pyridone base pairs
Wenjue Fan1,2, Hidenori Okamura*1,2, Zhuoxin Dong1,2, Giang Hoang Trinh1,2, Fumi
Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, 2Graduate School of

Science, Tohoku University

2P-08

Multidrug-integrated mini-nucleic acid drug platform for effective chemotherapy ofrefractory cancer
Ryosei Komiyama, Kunihiko Morihiro*, Akimitsu Okamoto*Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

2P-09

Synthesis of guanosine 3’, 5’-tetraphosphate (ppGpp) and its 2’-modified derivatives
Kohji Seio*, Kentaro Ohno, Daiki Sugiyama, Koh Akai, Ayano Iwake, Yudai Suzuki,
Yukine Suda, Yoshiaki Masaki
Department of Life Science and Technology, Tokyo Institute of Technology

2P-10Construction of Catalytic Target RNA Cleavage Function Installed Nucleic Acids for
the Treatments of COVID-19
Kazutoshi Fujita1, Nozomu Ishiwata1, Masahito Inagaki2, Masaki Nishijima1,
Hironori Hayashi3, Yu Mikame4, Yasuyuki Araki1, Tsuyoshi Yamamoto4, Asako Yamayoshi4,
Eiichi Kodama3, Takehiko Wada*1
1IMRAM, Tohoku Univ., 2Grad. Sch. Sci., Nagoya Univ., 3IRIDeS, Tohoku Univ., 4Grad. Sch. Biomed. Sci.,

Nagasaki Univ.

2P-11

Synthesis of Nucleoside Analogues with the Ability to Form Triplex DNA and Their
Application to Antigene Method
Yosuke Taniguchi*1, Lei Wang3, Ryotaro Notomi1, Shigeki Sasaki2
1Graduate School of Pharmaceutical Sciences Kyushu University, 2Graduate School of Pharmaceutical

Sciences, Nagasaki International University, 3School of Pharmacy and Jiangsu Province Key Laboratory for
Inflammation and Molecular Drug Target, Nantong University

2P-12

DNase II efficiently degrades RNA and the enzyme digestion products are available fororganisms
Jingyun Zhuang1, Haoyu Wang1, Xinmei Du1, Ran An*1,2, Xingguo Liang*1,2
1College of Food Science and Engineering, Ocean University of China, 2Laboratory for Marine Drugs andBioproducts, Qingdao National Laboratory for Marine Science and Technology

2P-13

Synthesis and property of GalNAc-modified dumbbell-shaped decoy oligonucleotides for
artificial control of HNF-4α
Hiromu Ueno, Kaito Takashima, Kanae Sato, Yusuke Inoue, Nozomi Ishii, Ichiro Matsuo,
Tomohisa Moriguchi*
Graduate School of Science and Technology, Gunma University

2P-14

Improvement of G-quadruplex-forming DNA aptamer for α-synuclein oligomer by loop
modification
Akari Sato, Kaori Tsukakoshi*, Kazunori Ikebukuro*
Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University ofAgriculture and Technology

2P-15

Effects of intracellular molecular environments during cancer progression on i-motif
formations
Kun Chen1, Hisae Tateishi-Karimata1, Naoki Sugimoto*1,2
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University 2Graduate School of

Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

2P-16

Interstrand-crosslinking using 2’-deoxythioguanosine-containing oligonucleotides
Jamila Osman1,2, Kazumitsu Onizuka*1,2, Yuuhei Yamano1,2, Ahmed Mostafa Abdelhady1,2,
Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, 2Graduate School of Science, Tohoku

University

2P-17

Formation of pseudorotaxane and catenane structures using novel cyclized
oligodeoxynucleotides
Kazuki Kuwahara1,2, Kazumitsu Onizuka*1,2, Sayaka Yajima1,2, Yuuhei Yamano1,
Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2Department of Chemistry,

Graduate School of Science, Tohoku University

2P-18Synthesis of artificial nucleotide strands containing modified bases by various DNA
polymerase variants
Rei Katou1, Kouki Tajiri1, Erika Nagatani1, Hidekazu Hoshino2, Yuuya Kasahara2,3,
Satoshi Obika2,3,4, Yuka Kataoka1, Masayasu Kuwahara*1
1GraduateSchoolofIntegratedBasicSciences,NihonUniversity, 2National Institutes of Biomedical

Innovation,Health and Nutrition, 3Graduate School of Pharmaceutical Sciences, Osaka University, 4Institutefor Open and Transdisciplinary Research Initiatives, Osaka University

2P-19

Synthesis and fluorescent property of 2’-O-methyl RNA containing amide-linked RNA
modified with pyrene at the 2’-position
Reiko Iwase*, Fumiya Ikeda, Masatoshi Kadomatsu, Miki Hayakawa, Gaku Nakajima,
Miki Ando, Misaki Hashimoto
Department of Life & Health Sciences, Faculty of Life & Environmental Sciences, Teikyo University of
Science

2P-20

Accumulation behaviors for GGGGCC-repeated RNA with peptide repeats estimated bymolecular dynamics simulations
Tatsuya Ohyama1, Hisae Tateishi-Karimata1, Shigenori Tanaka2, Chiduru Watanabe3,
Teruki Honma3, Naoki Sugimoto*1,4
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School of

System Informatics, Kobe University, 3RIKEN Center for Biosystems Dynamics Research, 4Graduate Schoolof Frontiers of Innovative Research in Science and Technology (FIRST), Konan University

2P-21

Drug Strategies for Selective Cancer Treatment Using Stimuli-Responsive Artificial
Nucleic Acids
Yasuhiro Tomida, Honami Ando, Kunihiko Morihiro*, Akimitsu Okamoto*Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo

2P-22

Study on read-through of premature termination codon by site-specificchemical modification
Jeongsu Lee1,2, Hirotaka Murase1,4, Norihiro Togo3, Yosuke Taniguchi3, Shigeki Sasaki*1,2
1Graduate School of Pharmaceutical Sciences, Nagasaki International University, 2RINAT Imaging Inc.,

3Graduate School of Pharmaceutical Sciences, Kyushu University, 4Faculty of Pharmaceutical Sciences, Sojo

University

2P-23

Development of a multiple-target detectable sensor based on DNA nanostructure
Mashal Asif, Eiji Nakata, Yuya Shibano, Khongorzul Gerelbaatar, Takashi Morii *Institute of Advanced Energy, Kyoto University

2P-24

Creation of base flipping-out structures on DNA and RNA using carbazole-modified
thymidine analogs
Kazumitsu Onizuka*1,2, Sayaka Yajima1,2, Yuuhei Yamano1, Madoka Sasaki1,2,Ahmed Mostafa Abdelhady1,2, Kei Ishida1,2, Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University 2Department of Chemistry,

Graduate School of Science, Tohoku University

2P-25

Development of pseudo-cellular systems to understand G-quadruplex behaviors
in cancer progression
Hisae Tateishi-Karimata*1, Keiko Kawauchi2, Shuntaro Takahashi1, Naoki Sugimoto*1,2
1Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2Graduate School ofLife Sciences, Ritsumeikan University, 3Graduate School of Frontiers of Innovative Research in Science andTechnology (FIRST), Konan University

2P-26

NMR determination of the binding mode of naphthyridine carbamate dimer (NCD) to
CGG repeat DNA
Takeshi Yamada1,2, Shuhei Sakurabayashi2,3, Noriaki Sugiura2, Kyoko Furuita3,
Chojiro Kojima3,4, Kazuhiko Nakatani*2
1Nucleotide and Peptide Drug Discovery Center, Tokyo Medical and Dental University, 2Department ofRegulatory Bioorganic Chemistry, SANKEN, Osaka University, 3Institute for Protein Research, Osaka
University, 4Graduate School of Engineering Science, Yokohama National University

2P-27

Photooxidation of guanine in duplexes by various biphenyl photosensitizer-oligonucleotide
conjugates and their sensitizing mechanisms
Takashi Kanamori*, Shota Kaneko, Yaoyao Du, So Nemoto, Nanai Yoshida, Masashi Ozawa,
Hideya Yuasa*
School of Life Science and Technology, Tokyo Institute of technology

2P-28

Biochemical applications of long polynucleotides prepared with terminal
deoxynucleotidyl transferase
Akiho Kawamoto, Aki Tanaka, Mitsunobu Nakamura, Tadao Takada*
Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo

2P-29

Bioconjugation reaction of nucleoside derivatives by water-soluble nanoparticles
possessing photoredox catalysis
Shiori Sugano, Ken Nishioka, Mitsunobu Nakamura, Tadao Takada*
Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo

2P-30

Construction of DNA-RNase H conjugates using photo-cross-linking ODNs
Kentaro Kobata, Kazuya Matsuo, Tomonori Waku, Akio Kobori*
Graduate school of science and technology, Kyoto Institute of Technology

2P-31

Cu(II)-responsive Allosteric DNAzyme Prepared by Enzymatic Ligation of 5-Carboxyuracil
Oligomers
Yusuke Takezawa*, Hanci Zhang, Keita Mori, Lingyun Hu, Mitsuhiko Shionoya*
Department of Chemistry, Graduate School of Science, The University of Tokyo

2P-32

Development of PROTAC ligands for G-quadruplex binding proteins
Rena Nohara1, Yuuma Tanaya1, Yue Ma2, Kazuo Nagasawa1, Masayuki Tera*1
1Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2Research Core Center,

Tokyo Medical and Dental University

2P-33

Studies on Molecular Design and Synthesis of Chimeric Artificial Nucleic Acids (CANA) for
Increasing the Catalytic Turnover Number of RNase H Mediated Target RNA Cleavage:
Towards Pancreatic Cancer Treatment
Yuto Horiuchi1, Nozomu Ishiwata1, Kazutoshi Fujita1, Masaki Nishijima1, Yasuyuki Araki1,
Masaki Sato2, Mitsuyo Matsumoto2, Kazuhiko Igarashi2, Takehiko Wada*1
1Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University, 2Graduate

School of Medicine, Tohoku University

2P-34

Topological Capture of mRNA for Silencing Gene Expression
Yasuaki Kimura*1, Takashi Tomita1, Fangjie Lyu1, Naoko Abe1, Haruka Hiraoka1,
Fumitaka Hashiya1, Yuko Nakashima1, Shiryu Kajihara1, Fumiaki Tomoike1,
Kazumitsu Onizuka2, Hiroshi Abe*1,3,4
1Graduate School of Science, Nagoya University, 2Institute of Multidisciplinary Research for Advanced

Materials, Tohoku University, 3Institute for Glyco-core Research, Nagoya University, 4JST-CREST

2P-35Development of intracellular sequence-specific DNA photocrosslinking by photochemical
double duplex invasion DNA
Kenzo Fujimoto*, Shigetaka Nakamura, Toya Odai, Zumila Hailili, Junling Mo,
Toshifumi Tsukahara
Biofunctional Medical Engineering Research Area, Japan Advanced Institute of Science and Technology

2P-36

400 mer Double Duplex Invasion Via Ultra-Fast DNA Photo-Cross-Linking
Zumila Hailili, Yasuha Watanabe, Toya Odai, Siddhant Sethi, Kenzo Fujimoto *Biofunctional Medical Engineering Research Area, Japan Advanced Institute of Science and Technology

2P-37

Precise control for the formation of various topoisomers of a short dsDNA by using
corresponding DNA scaffolds
Mengqin Liu1,2, Hui Chen1, Ran An1,3, Xingguo Liang*1,3
1College of Food Science and Engineering, Ocean University of China, 2School of Medicine and Pharmacy,

Ocean University of China, 3Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for
Marine Science and Technology

2P-38

Development an artificial nucleoside capable of recognizing 5mCG and CG base pairs andnew application studies of triplex DNA
Ryotaro Notomi1, Shigeki Sasaki2, Yosuke Taniguchi*1
1Graduate School of Pharmaceutical Science, Kyushu University, 2Graduate School of Pharmaceutical

Science, Nagasaki International University

2P-39

Development of pyrrole-imidazole polyamides that target CCTG/CAGG repeat DNA in
Myotonic Dystrophy Type 2
Karen Kobayashi1, Junnosuke Hatanaka1, Kaori Hashiya1, Hiroshi Sugiyama*2,
Toshikazu Bando*1
1Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-

Material Sciences (iCeMS), Kyoto University

2P-40

Photocontrol of ribozyme structure and function by the photoresponsive RNA binder
Chikara Dohno*1,2, , Maki Kimura1, Yusuke Fujiwara1,2, Kazuhiko Nakatani*1,2
1Department of Regulatory Bioorganic Chemistry, SANKEN (The Institute of Scientific and Industrial

Research), Osaka University, 2CREST, JST

2P-41

A novel bimolecular left-handed quadruplex DNA association by the binding of mercury ion
to thrombin binding aptamer
Yui Miyahara1, Kohsei Sekiya1, Jiro Kondo2, Hidetaka Torigoe*1
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, 2Department of Materials

and Life Sciences, Sophia University

2P-42

Development of quadruplex nucleic acid-based methods to artificially repress target gene
expression
Hanako Takahashi, Hidetaka Torigoe*
Department of Applied Chemistry, Faculty of Science, Tokyo University of Science

2P-43

Regulation effect of structure-selective G-quadruplex ligand on telomere length-TERRA
expression relationship
Yoshiki Hashimoto1, Keiko Kawauchi1, Hisae Tateishi-Karimata2, Naoki Sugimoto1,2,
Daisuke Miyoshi*1
1Frontiers of Innovative Research in Science and Technology, Konan University, 2Frontier Institute for

Biomolecular Engineering Research, Konan University

2P-44Development of a Novel Synthetic Ligand to Visualize the Mitochondrial G-quadruplex
Ryohei Noizumi1, Daisuke Sasaki1, Mitsuharu Ooga1, Hiroshi Sugiyama*2,
Toshikazu Bando*1
1Department of Chemistry, Graduate School of Science, Kyoto University, 2Institute for Integrated Cell-

Material Sciences (iCeMS), Kyoto University

2P-45

BasePairPuzzle: Molecular models to understand the concept of base pairing
Jiro Kondo*, Shota Nakamura
Department of Materials and Life Sciences, Sophia University

2P-46

Ligation reaction on Capped RNA substrates by a Ligase Ribozyme
Nae Sakimoto1, Riki Hatakenaka2, Emily Matsusaka2, Natsuki Doi2, Akane Kiyose2,
Junji Kawakami*1,2
1Konan Laboratory for Oligonucleotide Therapeutics (KOLOT), 2Department of Nanobiochemistry, FIRST,

Konan University

2P-47

High-throughput analysis/screening of methyltransferase ribozymes by mutational
profiling
Ryota Yamagami*, Takumi Wada, Tsuyoshi Morita, Hina Kubota, Hiroyuki Hori
Graduate School of Science and Engineering, Ehime University

2P-48

Substrate tethered oligodeoxynucleotides for the comprehensive analysis ofaminopeptidase activities
Reoto Mio, Tatsuya Nishihara, Kazuhito Tanabe*College of Science and Engineering, Aoyama Gakuin University

2P-49

Three-dimensional DNA hexagonal prisms for cascaded enzyme reactions
Peng Lin1, Hui Yang2, Eiji Nakata1, Takashi Morii*1
1Institute of Advanced Energy, Kyoto University, 2Graduate School of Energy Science, Kyoto University

2P-50

Generation of an RNA aptamer neutralizing dengue viruses by SELEX method targetingvirus like particles and advanced in silico analyses
Ryo Amano1, Akiya Michishita2, Ryota Nakano2, Akiko Ichinose2, Kazumi Haga3,
Meng Ling Moi3, Michiaki Hamada2, Yoshikazu Nakamura1, 4, Masaki Takahashi*1
1Project Division of RNA Medical Science, The Institute of Medical Science, The University of Tokyo,
2Graduate School of Advanced Science and Engineering, Waseda University, 3School of International Health,Graduate School of Medicine, The University of Tokyo, 4RIBOMIC Inc.

2P-51

Selective capturing and release of cancer cells using an anti-EpCAM aptamer-modified
microfilter
Yusuke Kitamura*1, Kazane Chijiiwa1, Shota Kawabe1, Yuta Nakashima1, Keiichiro Yasuda2,
Masaaki Iwatsuki3, Yousuke Katsuda1, Hideo Baba3, Yoshitaka Nakanishi1, Toshihiro Ihara*1
1Faculty of Advanced Science and Technology, Kumamoto University, 2OGIC Technologies Co., Ltd., 3Facultyof Life Sciences, Kumamoto University

2P-52

G-quadruplex Genome-wide mapping using biotin-modified cyclic naphthalene
diimide derivatives
Shinobu Sato1, Satoshi Fujii2, Ryuki Hidaka1, Ruka Tamuta1, Shigeori Takenaka*1
1Department of Applied Chemistry, Kyushu Institute of Technology, 2Department of Bioscience andBioinformatics, Kyushu Institute of Technology

2P-53

Hierarchical self-assembly of multi-stimuli-responsive DNA origami nanoactuator
Shin Watanabe1, Reo Toho1, Ibuki Kawamata2, Yuki Suzuki*1
1Department of Chemistry for Materials, Graduate School of Engineering, Mie University, 2Department of

Robotics, Graduate School of Engineering, Tohoku University

2P-54Multi-reconfigurable DNA nanodevice actuated by the combination of orthogonal signals
Yuki Suzuki*1, Kotaro Watanabe2, Yuri Kobayashi1, Ibuki Kawamata2, Satoshi Murata2
1Department of Chemistry for Materials, Graduate School of Engineering, Mie University, 2Department of

Robotics, Graduate School of Engineering, Tohoku University

2P-55

Oligonucleotides are directly assimilated by yeast as an excellent nitrogen source andpromote nucleoside utilization
Xinmei Du1, Ran An1, 2, Jingyun Zhuang1, Xingguo Liang*1, 2
1College of Food Science and Engineering, Ocean University of China, 2Laboratory for Marine Drugs andBioproducts of Qingdao National Laboratory for Marine Science and Technology

2P-56

Fluorescence imaging of nucleic acid quadruplex structure using D3A-type
quinone-cyanine fluorescent dyes
Takashi Sakamoto*1, Yuka Muraoka1, Zehui Yu2, Mayuko Kawatake2
1Graduate School of Systems Engineering, 2Faculty of Systems Engineering, Wakayama University

2P-57

Spontaneous division of information and function during in quasi-cell RNA evolution
Shigeyoshi Matsumura*, Kaishu Terada, Yoshiki Hirota, Motochika Ehara, Yoshiya Ikawa
Graduate School of Science and Engineering, University of Toyama

2P-58

The Chimera Approach to Functional Nucleobase Modifications in PNA
Robert H.E. Hudson*, Mria Chowdhury, Gyeongsu Park
Department of Chemistry, The University of Western Ontario