Kanazawa Medical University
Research Activities and Publications
VOL. 24 2012

Kanazawa Medical University

I
Code

Department

Basic

N
Page

D E

X

Code

Department

Page

Medicine

0100

Department of Anatomy Ⅰ ･･････････････････ 1

0420

Department of General and Digestive Surgery ･･63

0110

Department of Anatomy Ⅱ ･･････････････････

2

0430

Department of Orthopedics Surgery ･･･････････ 66

0120

Department of Physiology Ⅰ･･････････････････ 30440

Department of Neurosurgery ･････････････････ 69

0130 Department of Physiology Ⅱ ･･････････････････ 50450

Department of Plastic and Reconstructive

0140

Department of Biochemistry Ⅰ･･･････････････ 7

Surgery ････････････････････････････････････ 71

0150

Department of Biochemistry Ⅱ ･･････････････ 80460

Department of Pediatric Surgery ･･････････････ 74

0160

Department of Pharmacology ････････････････ 100470

Department of Ophthalmology ････････････････ 75

0170

Department of Pathology Ⅰ･･････････････････ 110480

Department of Otorhinolaryngology

0180

Department of Pathology Ⅱ･･･････････････････ 120190

Department of Microbiology ･････････････････ 140490

Department of Dermatology･･･････････････････ 80

0200

Department of Immunology ･･･････････････････ 150500

Department of Urogenital Surgery ････････････ 82

0210

Department of Medical Zoology･･･････････････ 160510

Department of Obstetrics and Gynecology ･････ 84

0220

Department of Pathology and Laboratory

0520

Department of Anesthesiology and-Head and Neck Surgery ･････････････････････ 78

Perioperative Medicine ･･････････････････････ 87

Medicine ･･･････････････････････････････････ 170230

Department of Social and Environmental

0540

Department of Physical and Rehabilitation
Medicine ･･･････････････････････････････････ 89

Medicine ･･･････････････････････････････････ 190240 Department of Epidemiology and Public Health ･･･ 210550

Department of Emergency Medicine････････････ 91

0250

Department of Legal Medicine ･･･････････････ 25

0570

District medical ･････････････････････････････ 92

0260

Department of Medical Education ････････････ 260575

Department of Gastroenterological Endoscopy･･ 930580

Department of Oral and Maxillofacial Surgery･･ 94

ClinicalMedicine

0300

Department of Cardiology ･････････････････････27

0310

Department of Respiratory Medicine ････････････29

8010 Fundamental Nursing

0320

Department of Gastroenterology ･････････････ 31

8040

Adult Nursing

0330

Department of Nephrology ････････････････････ 35

8050

Gerontological Nursing

0340

Department of Diabetology and Endocrinology･･･ 37

8060 Pediatric Nursing

0350

Department of Hematology and Immunology ･･･ 40

8070

Maternity Nursing・Midwifery

0360

Department of Neurology ･････････････････････ 44

8080

Community Health Nursing

0363

Department of Medical Oncology ･･････････････ 47

8085 Psychiatric and Mental Health Nursing･･･････ 101

0366

Department of Infectious Diseases ･････････････ 49

8090

Home Care Nursing

0368

Department of General Internal Medicine ･･････ 51

8095

Comprehensive Nursing ････････････････････ 103

0370

Department of Geriatric Medicine･･････････････ 52

8100

Medical Science

0380

Department of Pediatrics ･････････････････････ 54

0390

Department of Neuropsychiatry ･･･････････････ 56

0400

Department of Radiology ･････････････････････ 58

8510

0410

Department of Cardiovascular Surgery ･･････ 60

8530 Life Science (Physical Education) ･･･････････････ 109

0415

Department of Thoracic Surgery ･･････････････ 61

8550 Human Science (Humanities) ････････････････ 110

Schoolof

Nursing････････････････････

95････････････････････････････

96････････････････････ 97･････････････････････････

98･････････････ 99･･･････････････ 100･･･････････････････････ 102･･･････････････････････････ 104

LiberalArts

Department of Life Science(Natural Science) ･･ 107

CodeDepartment

Page

8570

Human Science (Mathematics) ･･･････････････ 111

8590

Human Science (Foreign Languages) ･･････････ 112

University

Hospital

0640

Endoscopy Center ････････････････････････････ 114

0675

Health Evaluation Center ････････････････････116

MedicalResearch

Institute

7100

Department of Life Science････････････････････ 119

7200

Department of Advanced Medicine･････････････ 123

7310

Division of HT Research･･････････････････････ 128

7320

Division of Vision Research forEnvironmental Health････････････････ 130

7330

Division of Dermatomycology･･････････････････ 133

Affiliated9050

Institution

Center for FDD-MB･･････････････････････････ 135

9030 North Noto Institute of Community Medicine･･･ 136

Himi
9100

Municipal

Hospital

Himi Municipal Hospital･････････････････････ 137

CodeDepartment

Page

Bas i c M e d i c i n e

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Associate Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata,
T.Takegami, H.Mogami, K.Yamaguchi, T.Nakamura, H.Otani, T.Hatta, H.Shoji: Expression pattern of Galectin 4
in rat placentation, Placenta, 33:885-887, 2012.

－ 1 －

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy, embryology, lymphatic vessels, microscopy

Associate Professor

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry, pituitary, cell proliferation, electron
microscopy

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy, central nervous system

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

Publications
Originals
0110B001(M.Kinoshita), H.Shinohara, O.Hori, N.Ozaki, F.Ueda, M.Nakada, J.Hamada, Y.Hayashi: Association fibers
connecting the broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy, J.
Neurosurg., 116:323-330, 2012.

0110B002

T.Shimokawa, S.Yasutaka, R.Kominami, H.Shinohara: Wound epithelium function in axolotl limb regeneration,
Okajimas Folia Anat. Jpn., 89:75-81, 2012.

－ 2 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Associate Professor

SUGAI Tokio

Neurophysiology

Assistant Professor

YAMAMOTO Ryo

Neuroscience

Researcher

LUO Xianwen

Analysis of Alzheimer disease model mice in search for new
therapeutic approaches

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001

Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato: Suppression of synaptic
plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients, Neurobiol. Dis., 45:610-615,
2012.

0120B002

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Multimodal cross-talk of olfactory and gustatory information in theendopiriform nucleus in rats, Chem. Senses, 37:681-688, 2012.

0120B003

I.Nomura, H.Takechi, N.Kato: Intraneuronally injected amyloid beta inhibits long-term potentiation in rat
hippocampal slices, J. Neurophysiol., 107:2526-2531, 2012.

0120B004

R.Yamamoto, Y.Ueta, T.Sugai, N.Kato: A serotonergic discrimination favoring synaptic inputs that accompany
robust spike firing in lateral amygdala neurons, Neuroscience, 220:119-130, 2012.

－ 3 －Presentations at Conference
International Conference (Presentations)
0120I001

R.Yamamoto, T.Sugai, N.Kato: Serotonergic modulation on excitatory and inhibitory synaptic transmission inlateral amygdala., Neuroscience 2012 -Society for Neuroscience-, (New Orleans, '12.10).

0120I002

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Neuroscience 2012 -Society for Neuroscience-, (New Orleans, '12.10).

0120I003

K.Tanaka, Y.Li, Y.Ishigaki, T.Takegami, M.Tanaka, M.Matsui, N.Kato: Effects of anti-NMDA receptor antibodies
from the patients with NMDA receptor encephalitis on the neurons, 11th International Congress of
Neuroimmunology, (Boston, '12.11).

－ 4 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology

Assistant Professor

TANIDA Mamoru

Circulatory Physiology

Researcher

YAMAMOTO Yuki

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

T.Shibamoto, M.Tsutsumi, Y.Kuda, C.Ohmukai, W.Zhang, Y.Kurata: Mast cells are not involved in the ischemiareperfusion injury in perfused rat liver, J. Surg. Res., 174:114-119, 2012.

0130B002

W.Zhang, T.Shibamoto, Y.Kuda, S.Shinomiya, Y.Kurata: The responses of the hepatic and splanchnic vascular
beds to vasopressin in rats, Biomed. Res., 33:83-88, 2012.

0130B003

Y.Kurata, I.Hisatome, T.Shibamoto: Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger insinoatrial node pacemaking: insights from bifurcation analysis of mathematical models, Am. J. Physiol. Heart Circ.
Physiol., 302:H2285-H2300, 2012.

0130B004(S.Suzuki), Y.Kurata, P.Li, T.Notsu, A.Hasegawa, N.Ikeda, M.Kato, J.Miake, S.Sakata, G.Shiota, A.Yoshida,
H.Ninomiya, K.Higaki, K.Yamamoto, Y.Shirayoshi, I.Hisatome: Stabilization of Kv1.5 channel protein by bepridil
through its action as a chemical chaperone, Eur. J. Pharmacol., 696:28-34, 2012.

0130B005(H.Fujii), Y.Ikeuchi, Y.Kurata, N.Ikeda, U.Bahrudin, P.Li, Y.Nakayama, R.Endo, A.Hasegawa, K.Morikawa,
J.Miake, A.Yoshida, K.Hidaka, T.Morisaki, H.Ninomiya, Y.Shirayoshi, K.Yamamoto, I.Hisatome:
Electrophysiological properties of prion-positive cardiac progenitors derived from murine embryonic stem cells,
Circ. J., 76:2875-2883, 2012.

－ 5 －0130B006

W.Zhang, T.Shibamoto, Y.Kuda, Y.Kurata, S.Shinomiya, H.Kida, H.Tsuchida: Vascular perfusion limits mesentericlymph flow during anaphylactic hypotension in rats, Am. J. Physiol. Regul. Integr. Comp. Physiol., 302:R1191R1196, 2012.

Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, E.Zhang, Y.Kuda, Y.Kurata: The effect of systemic anaphylaxis on mesenteric lymph flow inanesthetized rats, Experimental Biology 2012, (San Diego (USA), '12.04).

0130I002

T.Shibamoto, E.Zhang, Y.Kuda, Y.Kurata: The effect of systemic anaphylaxis on mesenteric lymph flow inanesthetized rat, 7th Congress of the International Federation of Shock Societies, (Florida (USA), '12.06)，Shock,37 Suppl1:103, 2012.

0130I003

M.Kitadate, T.Shibamoto, H.Tonami: Hepatic angiographic study in rat anaphylactic shock, 7th Congress of theInternational Federation of Shock Societies, (Florida (USA), '12.06)，Shock, 37 Suppl1:94, 2012.

－ 6 －

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Senior Assistant Professor

HASHIMOTO
Mitsumasa

Cell biology, DNA repair, Cell cycle, p53-binding proteins

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SUNATANI Yumi

Molecular biology, DNA repair, p53-binding proteins

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

J.Yoshida, K.Iwabuchi, T.Matsui, T.Ishibashi, T.Masuoka, M.Nishio: Knockdown of stromal interaction molecule 1(STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid
carcinoma A431 cells, Biochem. Pharmacol., 84:1592-1603, 2012.

－ 7 －

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Faculty

Associate Professor

Molecular mechanisms of angiogenesis, Alternative mRNA processing,MicroRNA function
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
proteinAssistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001(T.Sugihara), S.Munesue, Y.Yamamoto, S.Sakurai, N.Akhter, Y.Kitamura, K.Shiba, T.Watanabe, H.Yonekura,
Y.Hayashi, J.Hamada, H.Yamamoto: Endogenous secretory receptor for advanced glycation end-products inhibits
amyloid-β1-42 uptake into mouse brain, J. Alzheimers Dis., 28:709-720, 2012.

0150B002(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

0150B003

T.Ikeda, S.Takasawa, N.Noguchi, K.Nata, A.Yamauchi, I.Takahashi, T.Yoshikawa, A.Sugawara, H.Yonekura,
H.Okamoto: Identification of a major enzyme for the synthesis and hydrolysis of cyclic ADP-ribose in amphibian
cells and evolutional conservation of the enzyme from human to invertebrate, Mol. Cell. Biochem., 366:69-80,
2012.

Presentations at Conference
International Conference (Presentations)－ 8 －0150I001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, E.Kubo, H.Sasaki, H.Yonekura: Ultraviolet Binduced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, International
Conference on The Lens, (Hawaii, '12.01).

0150I002

Y.Yoshitake, T.Ikeda, Y.Yoshitomi, H.Yonekura: Increased expression of Epac2 during in vitro tube formation inhuman microvascular endothelial cells, 22nd IUBMB & 37th FEBS Congress, (Sevilla, '12.09).

－ 9 －

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor(Additional Post)

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Senior Assistant Professor

MASUOKA Takayoshi

Researcher

IMAIZUMI Noriko

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemPharmacology in cardiovascular system, Cancer chemotherapy
Electrophysiology and behavioural pharmacology in central andperiphenal nervous system
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary circulation,
nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug,
proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

J.Yoshida, K.Iwabuchi, T.Matsui, T.Ishibashi, T.Masuoka, M.Nishio: Knockdown of stromal interaction molecule 1(STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid
carcinoma A431 cells, Biochem. Pharmacol., 84:1592-1603, 2012.

0160B002

K.Miyazawa, Y.Takahashi, N.Morita, M.Moriyama, T.Kosaka, M.Nishio, T.Yoshimoto, K.Suzuki: Cyclooxygenase 2
and prostaglandin E2 regulate the attachment of calcium oxalate crystals to renal epithelial cells, Int. J. Urol.,
19:936-943, 2012.

－ 10 －

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Professor(Additional Post)

KOHNO Hiroyuki

Experimental pathology, Tumor immunology

Assistant Professor

YOSHIZAKI Hisayoshi Molecular and Cellular Biology，Fluorescent Imaging

Researcher

NISHIHAMA Harumi

Molecular and Cellular Biology

Researcher

HARUTA Yui

Molecular and Cellular Biology

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin

Outline of Research
Based on the principal of FRET, we generate biosensors to investigate cell signalling pathways. We also develop the system
to manipulate cell signalling to understand the molecular mechanisms for cancer development and morphology.

Publications
Originals
0170B001(S.Yagi), M.Matsuda, E.Kiyokawa: Suppression of Rac1 activity at the apical membrane of MDCK cells is essential
for cyst structure maintenance, EMBO Rep., 13:237-243, 2012.

0170B002(A.Sakurai), M.Matsuda, E.Kiyokawa: Activated ras protein accelerates cell cycle progression to perturb MadinDarby canine kidney cystogenesis, J. Biol. Chem., 287:31703-31711, 2012.

0170B003(S.Yagi), M.Matsuda, E.Kiyokawa: Chimaerin suppresses Rac1 activation at the apical membrane to maintain thecyst structure, PLoS ONE, e52258, 2012.

Reviews
0170C002

E.Kiyokawa: Visualization of lipids by FRET biosensors, J. Kanazawa. Med. Univ., 37:59-65, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0170I001

E.Kiyokawa: Mechanisms for luminal cell filling induced by active Rac 1and K-Ras, American Society ofInvestigative Pathology Annual Meeting at Experimental Biology 2012, (San Diego, USA, '12.04).

－ 11 －

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Neuropathology

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001(T.Munehiro), K.Kitaoka, Y.Ueda, Y.Maruhashi, H.Tsuchiya: Establishment of an animal model for delayed-onset
muscle soreness after high-intensity eccentric exercise and its application for investigating the efficacy of low-load
eccentric training, J. Orthop. Sci., 17:244-252, 2012.

0180B002

T.Ichiseki, A.Kaneuji, Y.Ueda, S.Kaneko, S.Ueda, T.Matsumoto: The initial phase of oxidative stress in a steroidinduced osteonecrosis rabbit model, Adv Biosci Biotechnol, 3:978-982, 2012.

0180B003

Y.Machida, Y.Ueda, M.Ueno, M.Tanaka, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: The aquaporin family:A novel
player in the progression of adenocarcinoma of the lung, Proceedings of the Japanese Lung Cancer Society Lungcancer., 52:17-22, 2012 (in Japanese) .

Case Reports
0180D002(K.Yamashita), D.Ishikawa, S.Nanjyo, S.Takeuchi, T.Yamada, H.Mouri, K.Ohtsubo, K.Yasutomo, M.Kumagai,
Y.Ueda, S.Yano: A case of poorly-differentiated neuroendocrine carcinoma of the ascending colon with multiple
liver metastases successfully treated with cisplatin and irinotecan, Cancer & chemotherapy, 39:1427-1430, 2012
(in Japanese) .

－ 12 －

Presentations at Conference
International Conference (Presentations)
0180I001

A.Komuro, N.Koizumi, M.Yagishita, Y.Ueda, M.Shimasaki, S.Kawakami: Cartilage-progenitor cells in the
perichondrium and the acceleration of their early proliferation by bFGF in the perichondrium-preserved harvest of
rabbit costal cartilage, 11th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Awajishima, '12.05).

0180I002

Y.Machida, Y.Ueda, M.Shimazaki, M.Sagawa, T.Sakuma: Global histone H3 lysine4(H3K4) dimethylation is an
important prognostic factor in lung cancer, ERS VIENNA 2012, (Austria, '12.09).

0180I003

M.Yagishita, M.Shimasaki, Y.Ueda, S.Kawakami: Dual functions of aquaporin 1 in the regeneration of auricularelastic cartilage of rabbit, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

0180I004

A.Komuro, N.Koizumi, Y.Himi, M.Yagishita, Y.Ueda, M.Shimasaki, S.Kawakami: Cartilage-progenitor cells in the
perichondrium and the acceleration of their early proliferation by bFGF in the perichondrium-preserved harvest of
rabbit costal cartilage, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

－ 13 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology, Neuroimmunology

Professor

MURAKI Yasushi

Virology

Senior Assistant Professor

HIMEDA Toshiki

Neurovirology

Assistant Professor

OKUWA Takako

Virology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

T.Okuwa, Y.Muraki, T.Himeda, Y.Ohara: Glycosylation of CM2 is important for efficient replication of influenza C
virus, Virology, 433:167-175, 2012.

0190B002(E.Takashita), Y.Muraki, K.Sugawara, H.Asao, H.Nishimura, K.Suzuki, T.Tsuji, A.Hongo, Y.Ohara, Y.Kawaoka,
M.Ozawa, Y.Matsuzaki: Intrinsic temperature sensitivity of Influenza C virus hemagglutinin-esterase-fusion
protein, J. Virol., 86:13108-13111, 2012.

Reviews
0190C001

T.Himeda, Y.Ohara: Saffold virus, a novel human cardiovirus with unknown pathogenicity, J. Virol., 86:1292-1296,
2012.

Short Communications
0190E001

Y.Muraki, S.Hongo, Y.Ohara: Contamination of the cell sorter fluidics system with the water-borne bacterium
Burkholderia cepacia, Cytometry A, 81A:105-107, 2012.

Presentations at Conference
International Conference (Presentations)
0190I001

Y.Muraki: Role of the CM2 protein in Influenza C virus replication, International conference and exhibition on
metabolomics & systems biology, (San Francisco, '12.02).

0190I002

T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara: Reverse genetics of Saffold virus, 17th Europic conference, (SaintRaphael, '12.06).

－ 14 －

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology

Assistant Professor

TAKEDA Kazuya

Immunology, Neuropathology

Assistant Professor

WADA Toshiki

Immunology, Functional biochemistry, Structural biochemistry

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

Publications
Originals
0200B001(W.F.Wong), K.Kohu, A.Nakamura, M.Ebina, T.Kikuchi, R.Tazawa, K.Tanaka, S.Kon, T.Funaki, A.SugaharaTobinai, CY.Looi, S.Endo, R.Funayama, M.Kurokawa, S.Habu, N.Ishii, M.Fukumoto, K.Nakata, T.Takai,
M.Satake: Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous
hyperactivation of cells, J. Immunol., 188:5408-5420, 2012.

0200B002(Y.Mitsuhashi), A.Nakamura, S.Endo, K.Takeda, T.Yabe-Wada, T.Nukiwa, T.Takai: Regulation of plasmacytoid
dendritic cell responses by PIR-B, Blood, 120:3256-3259, 2012.

－ 15 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.2.Epidemiological research of tickborn diseases in the Noto Peninsula,Ishikawa Prefect.

Publications
Originals
0210B001

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.

0210B002(N.Yamazaki), A.Kobayashi, H.Yokogawa, Y.Ishibashi, Y.Oikawa, M.Tokoro, K.Sugiyama: Ex vivo laser confocal
microscopy findings of cultured Acanthamoeba trophozoites, Clin. Ophthalmol., 6:1365-1368, 2012.

0210B003(H.Yokogawa), A.Kobayashi, N.Yamazaki, Y.Ishibashi, Y.Oikawa, M.Tokoro, K.Sugiyama: Bowman's layerencystment in cases of persistent Acanthamoeba keratitis, Clin. Ophthalmol., 6:1245-1251, 2012.

－ 16 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Senior Assistant Professor

FUKUSHIMA Mana

surgical pathology

Assistant Professor

KINOSHITA Erikosurgical pathology, molecular pathology

Assistant Professor

NAKADA Satoko

surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001

K.Miyazawa, M.Matoba, H.Minato, N.Morita, I.Chikazawa, K.Ota, K.Tokunaga, H.Tonami, T.Nojima, K.Suzuki:
Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its
incidence and risk factors, Jpn. J. Radiol., 30:635-641, 2012.

0220B002(S.Suzuki), Y.Dobashi, H.Minato, R.Tajiri, T.Yoshizaki, A.Ooi: EGFR and HER2-Akt-mTOR signaling pathways
are activated in subgroups of salivary gland carcinomas, Virchows Arch., 461:271-282, 2012.

0220B003

S.Zhang, T.S.Kim, Y.Dong, S.Kanazawa, M.Kawaguchi, N.Gao, H.Minato, T.Takegami, T.Nojima, K.Asai, Y.Miura:
AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by
calpain-1, Biochem. Biophys. Res. Commun., 427:537-541, 2012.

0220B004

Y.Masaki, N.Kurose, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada, S.Matsui, T.Origuchi, S.Nishiyama,
K.Yamada, M.Kawano, A.Hirabayashi, K.Fujikawa, T.Sugiura, M.Horikoshi, N.Umeda, H.Minato, T.Nakamura,
H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.sawaki, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, K.Eguchi,
S.Sugai, H.Umehara: Cutoff values of serum IgG4 and histopathological IgG4+ plasma cells for diagnosis of patientswith IgG4-related disease, Int. J. Rheumatol., e580814,1-5, 2012.

－ 17 －

0220B005

M.Fukushima, K.Higuchi, H.Shimojo, T.Uehara, H.Ota: Distinct cytoplasmic expression of KL-6 mucin inchromophobe renal cell carcinoma:A comparative immunohistochemical study with other renal epithelial celltumors, Acta Histochem. Cytochem., 45:301-308, 2012.

Reviews
0220C001

H.Umehara, K.Okazaki, Y.Masaki, M.Kawano, M.Yamamoto, T.Saeki, S.Matsui, T.Sumida, T.Mimori, Y.Tanaka,
K.Tsubota, T.Yoshino, S.Kawa, R.Suzuki, T.Takegami, N.Tomosugi, N.Kurose, Y.Ishigaki, A.Azumi, M.Kojima,
S.Nakamura, D.Inoue: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details, Mod.
Rheumatol., 22:1-14, 2012.

Case Reports
0220D001

H.Minato, J.Shimizu, Y.Arano, K.Saito, T.Masunaga, T.Sakashita, T.Nojima: IgG4-related sclerosing mesenteritis:
A rare mesenteric disease of unknown etiology, Pathol. Int., 62:281-286, 2012.

0220D002

Y.Sasagawa, O.Tachibana, S.Siraga, H.Takata, E.Kinoshita, T.Nojima, H.Iizuka: Secondary malignant giant celltumor of the clivus: Case report, Clin. Neurol. Neurosurg., 114:786-788, 2012.

0220D003

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, K.Torigoe, T.Iida, E.Kinoshita:
Brain metastasis from testicular cancer : a case report, Japanese Journal of Urological Surgery, 25:1239-1242,
2012 (in Japanese) .

0220D004

I.Chikazawa, D.Nakai, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Minato, H.Tachibana,A.Kiyuyama: A case of renal cell carcinoma with cystic necrosis, J. Kanazawa. Med. Univ., 37:66-69, 2012 (inJapanese) .

0220D005

I.Chikazawa, T.Tanaka, K.Suzuki, E.Kinoshita: A case of Mixed epithelial and stromal tumor of the kidney, 泌外,
25:1883-1886, 2012 (in Japanese) .

0220D006

I.Chikazawa, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, T.Nojima: A case of adrenal hemorrhage due toadministration of anticoagulant, Japanese Journal of Clinical Urology, 66:965-968, 2012 (in Japanese) .

0220D007

N.Ueda, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, S.Kinami, K.Omote,Y.Nakano, T.Kosaka, S.Nakata, H.Minato, H.Takamura: A case of drug resistant recurrent gastrointestinal stromal
tumor treated surgically by resection, partial hepatectomy and diaphragmectomy, Cancer & chemotherapy,
39:2438-2440, 2012 (in Japanese) .

Others
0220F001(Y.Kiyohara), S.Sato, M.Yasuta, T.Okoshi, N.Hatta, T.Nojima, M.Kumakiri: Myxoid dermatofibrosarcoma
protuberans prominently involving subcutaneous tissue: Efficacy of molecular analysis, J. Dermatol., 1043-1044,
2012.

Presentations at Conference
International Conference (Presentations)
0220I001

H.Minato, M.Fukushima, N.Kurose, T.Nojima: Comparative immunohistochemical analysis to distinguish malignant
mesothelioma (MM) from reactive mesothelial cells (RMC), 101th Annual meeting of the United States andCanadian Academy of Pathology, (Vancouver, '12.03)，Mod Pathol, 25supple2:483A, 2012.

0220I002

K.Miyazawa, D.Nakai, N.Morita, I.Chikazawa, K.Suga, M.Moriyama, T.Tanaka, K.Suzuki, M.Matoba, H.Minato:
Analysis of incidence and risk factor of seed migration after transperineal interstitial prostate brachytherapy with I125 free seeds, The 32nd Congress of the Societe Internationaled Urologie, (Fukuoka, '12.10).

－ 18 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseasesProfessor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stressSenior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stressSenior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse,
Y.Suwazono, S.Kaneko, S.Sasaki, H.Nakagawa: Dietary glycemic index and risk of type 2 diabetes mellitus in
middle-aged Japanese men, Metabolism, 61:47-55, 2012.

0230B002

Y.Noborisaka, M.Ishizaki, M.Nakata, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Cigarette smoking,proteinuria, and renal function in middle-aged Japanese men from an occupational population, Environ. HealthPrevent. Med., 17:147-156, 2012.

0230B003

M.Nishijo, T.Pham-The, H.Nakagawa, S.Maruzeni, T.N.A.Nguyen, V.L.Hoang, H.A.Tran, R.Honda, Y.Morikawa,
T.Kido, H.Nishijo: Impact of perinatal dioxin exposure on infant growth: A cross-sectional and longitudinal studies
in dioxin-contaminated areas in Vietnam, PLoS ONE, 7:e40273, 2012.

0230B004

K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa: Overtime
work and blood pressure in normotensive Japanese male workers, Am. J. Hypertens., 25:979-985, 2012.

0230B005

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Self-reported speed of eating and 7-year risk of type 2 diabetes
mellitus in middle-aged Japanese men, Metabolism, 61:1566-1571, 2012.

0230B006

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Serum gamma-glutamyltransferase and the risk of hyperuricemia: a 6-year prospective study inJapanese men, Horm. Metab. Res., 44:966-74, 2012.

0230B007

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, K.Yoshita, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Alcohol intake and the risk of hyperuricaemia:A 6-year prospective study in Japanese men, Nutr.
Metab. Cardiovasc. Dis., 22:989-996, 2012.
－ 19 －

Presentations at Conference
International Conference (Presentations)
0230I001

K.Kagechika, M.Nakata, M.Tsubokawa, H.Kawasaki, M.Yamaguchi, S.Yura, A.Nakanami, Y.Takagi: Evaluation ofchange in dynamic property of vessel wall,dynamic deformability and strength of arteriosclerotic and ruptured bloodvessel by ultrasound, The 3rd Asia-Oceanian Conference of Physical and Rehabilitation Medicine, (Bali, '12.05).

0230I002(K.Nogawa), Y.Suwazono, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Change in tubularmarker and calcium excretion after cadmium exposure, 48th Congress of the European-Societies-of-Toxicology(EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

0230I003(Y.Suwazono), K.Nogawa, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Biological half-life ofblood cadmium level of inhabitants in cadmium-polluted area, 48th Congress of the European-Societies-ofToxicology (EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

0230I004

K.Kagechika, M.Nakata, M.Tsubokawa, H.Kawasaki, S.Yura, Y.Takagi: Pain can be estimated by measurement byelectric phenomenon, The 22nd Japanese-Korean Combined Orthpaedic Symposium, (Nikko, '12.06).

0230I005

K.Kagechika, F.Nogata, M.Nakata, M.Tsubokawa, H.Kawasaki, A.Nakanami, Y.Takagi: Ultasonic evaluation ofchange in dynamic property of vessel wall,dynamic deformability and strength of arteriosclerotic and ruptured bloodvessel, Asia Pasific Stroke Conference 2012, (Tokyo, '12.09).

－ 20 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Associate Professor

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

NAKANISHI Yumiko

Preventive medicine

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Books
0240A002

M.Sakurai, T.Ota, K.Miura, H.Nakagawa, S.Kaneko, T.Tamanura: BMI, waist circumference and metabolic
syndrome, Lessons from Japanese perspectives. In: The Handbook of Anthropometry, 1973-1988, V.R. Preedy,
London, 2012.

Publications
Originals
0240B001(R.Oka), K.Yagi, M.Sakurai, K.Nakamura, T.Moriuchi, S.Miyamoto, A.Nohara, M.Kawashiri, Y.Takeda,
M.Yamagishi: Insulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged
Japanese, Endocr. J., 59:55-64, 2012.

0240B002

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse,
Y.Suwazono, S.Kaneko, S.Sasaki, H.Nakagawa: Dietary glycemic index and risk of type 2 diabetes mellitus in
middle-aged Japanese men, Metabolism, 61:47-55, 2012.
－ 21 －

0240B003

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.

0240B004

K.Nakamura, M.Sakurai, M.Nishijo, Y.Morikawa, H.Nakagawa: Characteristics of smoking cessation in former
smokers in a rural area of Japan, Int J Prev Med, 3:459-465, 2012.

0240B005

M.Nishijo, T.Pham-The, H.Nakagawa, S.Maruzeni, T.N.A.Nguyen, V.L.Hoang, H.A.Tran, R.Honda, Y.Morikawa,
T.Kido, H.Nishijo: Impact of perinatal dioxin exposure on infant growth: A cross-sectional and longitudinal studies
in dioxin-contaminated areas in Vietnam, PLoS ONE, 7:e40273, 2012.

0240B006

K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa: Overtime
work and blood pressure in normotensive Japanese male workers, Am. J. Hypertens., 25:979-985, 2012.

0240B007(A.Fujiyoshi), T.Ohkubo, K.Miura, Y.Murakami, S.Nagasawa, T.Okamura, H.Ueshima, EPOCH-JAPAN ResearchGroup, H.Nakagawa: Blood pressure categories and long-term risk of cardiovascular disease according to age
group in Japanese men and women, Hypertens. Res., 35:947-953, 2012.

0240B008(The Emerging Risk Factors Collaboration), M.Sakurai, H.Nakagawa, K.Nakamura, Y.Morikawa: Adult height andthe risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis, Int.
J. Epidemiol., 41:1419-1433, 2012.

0240B009

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Self-reported speed of eating and 7-year risk of type 2 diabetes
mellitus in middle-aged Japanese men, Metabolism, 61:1566-1571, 2012.

0240B010(K.Ueda), S.Nagasawa, H.Nitta, K.Miura, H.Ueshima, for the NIPPON DATA80 research group, H.Nakagawa:Exposure to particulate matter and long-term risk of cardiovascular mortality in Japan : NIPPON DATA80, J.
Atheroscler. Thromb., 19:246-254, 2012.

0240B011

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Serum gamma-glutamyltransferase and the risk of hyperuricemia: a 6-year prospective study inJapanese men, Horm. Metab. Res., 44:966-74, 2012.

0240B012(N.Takashima), T.Ohkubo, K.Miura, T.Okamura, Y.Murakami, A.Fujiyoshi, S.Nagasawa, A.Kadota, Y.Kita,
N.Miyagawa, T.Hisamatsu, T.Hayakawa, A.Okayama, H.Ueshima: Long-term risk of BP values above normal for
cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years, J. Hypertens., 30:2299-2306,
2012.

0240B013

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, K.Yoshita, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Alcohol intake and the risk of hyperuricaemia:A 6-year prospective study in Japanese men, Nutr.
Metab. Cardiovasc. Dis., 22:989-996, 2012.

0240B014

K.Nakamura, H.Nakagawa, M.Sakurai, Y.Murakami, F.Irie, A.Fijiyoshi, T.Okamura, K.Miura, H.Ueshima, for the
EPOCH-JAPAN research group: Influence of smoking combined with another risk factor on the risk of mortality
from coronary heart disease and stroke: Pooled analysis of 10 Japanese cohort studies, Cerebrovasc. Dis., 33:480491, 2012.

0240B015(R.Oka), K.Yagi, M.Sakurai, K.Nakamura, S.Nagasawa, S.Miyamoto, A.Nohara, M.Kawashiri, K.Hayashi, Y.Takeda,
M.Yamagishi: Impact of visceral adipose tissue and subcutaneous adipose tissue on insulin resistance in middleaged Japanese, J. Atheroscler. Thromb., 19:814-822, 2012.

0240B016

Y.Morikawa, M.Tabata, T.Kido, Y.Koyama: Occupational class inequalities in behavioral and biological risk factors
for cardiovascular disease among workers in medium- and small-scale enterprises, Ind. Health, 50:529-539, 2012.

0240B017

PT.Tai, M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Loung, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LTM.Nguyet, LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Dioxin exposure and infant neurodevelopment – a follow up
study in Vietnamese infants, Organohalogen Compounds., 74:1369-1372, 2012.

0240B018

M.Nishijo, PT.Tai, NM.Nui, NTN.Anh, NM.Hai, S.Maruzeni, TN.Nghi, PT.Phoung, H.Nishijo, TH.Anh, HV.Loung,
T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Effects of dioxins exposure on social emotional behavior of children
living in a hot spot area, Vietnam, Organohalogen Compounds., 74:1332-1335, 2012.

－ 22 －

0240B019(T.Kido), R.Okamoto, HD.Manh, XL.Sun, NH.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, DV.Tung, DD.Nhu, NN.Hung, LK.Son: Dioxin in breast milk of Vietnamese mothers andsteroid hormone in saliva of their infants, Organohalogen Compounds., 74:1361-1364, 2012.

0240B020

S.Nagasawa, T.Okamura, H.Iso, A.Tamakoshi, M.Yamada, M.Watanabe, Y.Murakami, K.Miura, H.Ueshima, for the
EPOCH-JAPAN Research Group: Relation between serum total cholesterol level and cardiovascular diseasestratified by sex and age group: A pooled analysis of 65 594 individuals from 10 cohort studies in Japan, J. Am.
Heart Assoc., 1:e001974, 2012.

0240B021(TC.Turin), Y.Murakami, K.Miura, N.Rumana, Y.Kita, T.Hayakawa, T.Okamura, A.Okayama, H.Ueshima, and of
the NIPPON DATA80/90 Research Group, H.Nakagawa: Hypertension and life expectancy among Japanese:
NIPPON DATA80, Hypertens. Res., 35:954-958, 2012.

0240B022(A.Fujiyoshi), T.Ohkubo, K.Miura, Y.Murakami, S.Nagasawa, T.Okamura, H.Ueshima, for the Evidence for
Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, H.Nakagawa:Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men
and women, Hypertens. Res., 35:947-953, 2012.

0240B023(Y.Nakamura), T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, T.Ohkubo, K.Miura, F.Kasagi, K.Kodama,
A.Okayama, H.Ueshima, and for the NIPPON DATA80 Research Group, H.Nakagawa: Prognostic values ofclockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects : A 24-year follow-up of
the national integrated project for prospective observation of noncommunicable disease and its trends in the aged,
1980-2004(NIPPON DATA80)., Circulation, 125:1226-1233, 2012.

0240B024

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, H.Nakagawa: Relationship between participation in asecondary screening test for the frail elderly and new onset of the need for long-term care among the elderly in arural town, Japanese Journal of Public Health., 59:801-809, 2012 (in Japanese) .

Reviews
0240C001(T.Okamura), K.Nakamura, T.Hayakawa, H.Kanda, K.Miura, A.Okayama, H.Ueshima: Effect of cardiovascular risk
factors on individual and population medical expenditures : A 10-year cohort study of 4,535 national healthinsurance beneficiaries in Shiga, Japanese Journal of Hygiene, 67:38-43, 2012 (in Japanese) .

Short Communications
0240E001(TC.Turin), Y.Murakami, K.Miura, N.Rumana, A.Kadota, T.Ohkubo, T.Okamura, A.Okayama, H.Ueshima, for the
NIPPON DATA80 Researchi Group, H.Nakagawa: Diabetes and life expectancy among Japanese - NIPPONDATA80, Diabetes Res. Clin. Pract., 96:e18-22, 2012.

Presentations at Conference
International Conference (Presentations)
0240I001

K.Nakamura, H.Nakagawa, M.Sakurai, Y.Murakami, F.Irie, A.Fujiyoshi, T.Okamura, K.Miura, H.Ueshima:
Smoking, its combination with another risk factor and the risk of mortality from coronary heart disease and stroke:a pooled analysis of 10 Japanese cohort studies, The XVI International Symposium on Atherosclerosis (ISA2012),(Sydney,Australia, '12.03).

0240I002(K.Nogawa), Y.Suwazono, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Change in tubularmarker and calcium excretion after cadmium exposure, 48th Congress of the European-Societies-of-Toxicology(EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

0240I003(Y.Suwazono), K.Nogawa, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Biological half-life ofblood cadmium level of inhabitants in cadmium-polluted area, 48th Congress of the European-Societies-ofToxicology (EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

－ 23 －

0240I004

Y.Ishigaki, Y.Nakamura, T.Takehara, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Ionic liquid enables
simple and rapid sample preparation of human culturing cells for scanning electron microscope (SEM) analysis, 14th
International Congress of Histochemistry and Cytochemistry, (Kyoto, '12.08).

0240I005

TT.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, ATN.Nguyen, Loung.HV, Anh.TH, Y.Morikawa, T.Kido, H.Nishijo:
Dioxin exposure and infant neurodevelopment – a follow up study in Vietnamese infants., 32nd International
Symposium on Halogenated Persistent Organic Pollutants;Dioxin 2012, (Cairns, Australia, '12.08)，32nd
International Symposium on Halogenated Persistent Organic Pollutants; Dioxin 2012, 2012.

0240I006

M.Nishijo, Tai.PT, Nui.NM, Anh.NTN, Hai.NM, S.Maruzeni, Nghi.TN, Phoung.PT, H.Nishijo, Anh.TH, Loung.HV,
T.Kido, R.Okamoto, Son.LK, H.Nakagawa: Effects of dioxins exposure on social emotional behavior of children
living in a hot spot area, Vietnam, 32nd International Symposium on Halogenated Persistent Organic Pollutants;
Dioxin 2012, (Cairns, Australia, '12.08).

0240I007(T.Kido), R.Okamoto, Manh.HD, Sun.XL, Viet.NH, M.Nakano, Tai.PT, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, Tung.DV, Nhu.DD, Hung.NN, Son.LK: Dioxin in breast milk of Vietnamese mothers andsteroid hormone in saliva of their infants., 32nd International Symposium on Halogenated Persistent Organic
Pollutants; Dioxin 2012, (Cairns, Australia, '12.08).

0240I008

K.Kitaoka, Y.Morikawa, H.Nakagawa, S.Masuda, Y.Nagayama: Mental health nursing research on the Japaneseemployees, 18th International Network for Psychiatric Nursing Research, (Oxford, '12.09).

－ 24 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology, Drug Dependence

Senior Assistant Professor

WANG Lu elaine

Tumor pathology, Endocrine pathology, Forensic pathology

Assistant Professor

TAKEICHI Toshiaki

ER-stress, Drug Dependence

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001(T.Kamide), Y.Kitao, T.Takeichi, A.Okada, H.Mohri, A.M.Schmidt, T.Kawano, S.Munesue, Y.Yamamoto,H.Yamamoto, J.Hamada, O.Hori: RAGE mediates vascular injury and inflammation after global cerebral ischemia,
Neurochem. Int., 60:220-228, 2012.

0250B002

T.Takeichi, L.Wang, O.Kitamura: The effects of low-dose methamphetamine pretreatment on endoplasmic
reticulum stress and methamphetamine neurotoxicity in the rat midbrain, Leg. Med., 14:69-77, 2012.

0250B003

T.Takeichi, E.L.Wang, O.Kitamura: Effect of syringe filter on the detection diatom in formalin-fixed organs by
enzymatic digestion, The Research and Practice in Forensic Medicine., 55:99-103, 2012 (in Japanese) .

－ 25 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

YASUDA Yukio

Professor

HORI Ariyuki

Senior Assistant Professor

FUKUNAGA
Toshiharu

Assistant Professor

KURODA Naohiro

Facultyundergraduate clinical teaching, graduate education of physicians,
medical education
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
laboratory medicine, standardization of blood gas analysis, pulmonary
function test
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Presentations at Conference
International Conference (Presentations)
0260I001

T.Fukunaga: Quality Assurance of Blood Gasses using Certified Reference Materials, 24th International CPOCT
Symposium, (Praha, '12.10).

－ 26 －

C lin ic a l M e d i c i n e

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Associate Professor

KAWAI Yasuyuki

Associate Professor

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Associate
Professor(Additional Post)

ASAJI Takayoshi

Heart failure

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension

Assistant Professor

KASENO Kenichi

Arrhythmia, Catheter ablation

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention

Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Ischemic heart disease, Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001

K.Fujibayashi, Y.Kawai, M.Kitayama, H.Akao, R.Ishida, A.Motoyama, M.Wakasa, K.Arakawa, M.Ueki, T.Yasuda:Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina
pectoris or non-ST-segment elevation myocardial infarction, J. Cardiol., 59:258-265, 2012.
－ 27 －

0300B002

H.Akao, E.Polisecki, K.Kajinami, S.Trompet, M.Robertson, I.Ford, J.W.Jukema, A.J.M.de Craen,
R.G.J.Westendorp, J.Shepherd, C.Packard, B.M.Buckley, E.J.Schaefer: KIF6, LPA, TAS2R50, and VAMP8 genetic
variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in
the elderly, Atherosclerosis, 220:456-462, 2012.

0300B003

H.Akao, E.Polisecki, K.Kajinami, S.Trompet, M.Robertson, I.Ford, J.W.Jukema, A.J.M.de Craen,
R.G.J.Westendorp, J.Shepherd, C.Packard, B.M.Buckley, E.J.Schaefer: Genetic variation at the SLCO1B1 gene
locus and low density lipoprotein cholesterol lowering response to pravastatin in the elderly, Atherosclerosis,
220:413-417, 2012.

Presentations at Conference
International Conference (Presentations)
0300I001

K.Kajinami, H.Akao, E.Polisecki, M.Robertson, I.Ford, J.W.Jukema, J.Shepherd, C.Packard, B.Buckley,
E.Schaefer: SLCO1B1 Gene Variation and Low Density Lipoprotein Cholesterol Lowering Response to Pravastatin,
X VI International Symposium on Atherosclerosis, (Sydney, '12.03).

0300I002

H.Akao, E.Polisecki, K.Kajinami, M.Robertson, I.Ford, J.W.Jukema, J.Shepherd, C.Packard, B.M.Buckley,
E.J.Schaefer: KIF6, LPA, TAS2R50, and VAMP8 Genetic Variation, Low Density Lipoprotein Cholosterol
Lowering Response to Pravastatin, and Heart Disease Risk Reduction, X VI International Symposium on
Atherosclerosis, (Sydney, '12.03).

0300I003

T.Takamura, R.Saito, A.Motoyama, R.Ishida, K.Fujibayashi, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami:
Circulating PCSK9 Levels and Additional LDL Cholesterol-Lowering after Standard Dose Atorvastatin Therapy:
Comparison with Doubling dose and Ezetimibe Combination, ESC Congress 2012, (Munich, '12.08).

0300I004

K.Fujibayashi, Y.Kawai, S.Takano, M.Wakasa, N.Fujioka, K.Kajinami: Potential roles of taurine and beta-alanine inatrial fibrillation, European Society of Cardiology, (Munich, '12.08).

0300I005

H.Aoki, I.Matsunair, Y.Nomura, N.Takeda, K.Kajinami: Prognostic Value of HEDPBT and MIBG in Patients with
LV dysfunction, Annual Congress of the European Association of Nuclear Medicine, (Milan, '12.10).

－ 28 －

0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Senior Assistant Professor

HUANG Jyongsu

lung physiology, sleep disordered breathing

Senior Assistant Professor

MIZUNO Shirolung cell and molecular biology，COPD

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Senior AssistantProfessor(Additional Post)

IGUCHI Masaharu

clinical respiratory medicine

Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

KOBAYASHI Makoto lung cell and molecular biology

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

TSUCHIHARA
Katsumaclinical respiratory medicine, lung cancer

Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

YAMAYA Atsuyo

clinical respiratory medicine

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

HIGASHINO Mari

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Books
0310A004

S.Mizuno, H.Toga, T.Ishizaki: Hypoxic Pulmonary Vascular Smooth Muscle Cell Proliferation, Current basic andpathological approaches to the function of muscle cells and tissues-from molecules to humans(Haruo Sugi), 379390, INTECH, USA, 2012.

Publications
Originals－ 29 －

0310B001

S.Mizuno, M.Yasuo, H.J.Bogaard, D.Kraskauskas, A.Alhussaini, J.G.Arroyo, D.Farkas, L.Farkas, N.F.Voelkel:
Copper deficiency induced emphysema is associated with focal adhesion kinase inactivation, PLoS ONE, 7:e30678,
1-10, 2012.

0310B002(H.J.Bogaaｒd), S.Mizuno, C.Guignabert, A.A.Hussaini, D.Farkas, G.Ruiter, D.Kraskauskas, E.Fadel, J.C.Allegood,
M.Humbert, A.V.Noordegraaf, S.Spiegel, L.Farkas, N.F.Voelkel: Copper dependence of angioproliferation inpulmonary arterial hypertension in rats and humans, Am. J. Respir. Cell Mol. Biol., 46:582-591, 2012.

0310B003

S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi,
H.Toga: Sleep apnoea syndrome as a risk for mortality in elderly inpatients, J. Int. Med. Res., 40:601-611, 2012.

0310B004

S.Mizuno, H.J.Bogaard, J.G.Arroyo, A.Alhussaini, D.Kraskauskas, C.D.Cool, N.F.Voelkel: MicroRNA-199a-5p is
associated with hypoxia-inducible factor-1α expression in lungs from patients with COPD, Chest., 142:663-672,
2012.

0310B005

S.Mizuno, L.Farkas, A.A.Husseini, D.Farkas, J.G.Arroyo, D.Kraskauskas, M.R.Nicolls, C.D.Cool, H.J.Bogaard,
N.F.Voelkel: Severe pulmonary arterial hypertension induced by su5416 and ovalbumin immunization, Am. J.
Respir. Cell Mol. Biol., 47:679-687, 2012.

Reviews
0310C001(J.G.Arroyo), S.J.Saleem, S.Mizuno, A.A.Syed, H.J.Boggard, A.Abbate, L.T.Stewart, Y.Sung, D.Kraskauskas,
D.Farkas, D.H.Conrad, M.R.Nicolls, N.F.Voelkel: A brief overview of mouse models of pulmonary arterial
hypertension: problems and prospects, Am. J. Physiol. Lung Cell Mol. Physiol., 302:L977-L991, 2012.

0310C002(M.R.Nicolls), S.Mizuno, L.T.Stewart, L.Farkas, J.I.Drake, A.A.Husseini, J.G.G.Arroyo, N.F.Voelkel,
H.J.Bogaard: New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell
apoptosis, Pulm. Circ., 2:434-442, 2012.

Presentations at Conference
International Conference (Presentations)
0310I001

M.Zhou, K.Osanai, S.Kitadate, S.Shinomiya, M.Higashino, K.Tsuchihara, S.Mizuno, J.Huang, H.Toga: Exogenous
expression of lysophosphatidylcholine acyltransferase 1 protect alveolar type II cell from hydrogen peroxideinduced cell injury, 2012 ATS International Lung Conference, (San Francisco, '12.05)，Am. J. Respir. Crit. Care
Med., 185: A1999, 2012.

0310I002

S.Mizuno, H.J.Bogaard, D.Kraskauskas, A.Alhussaini, J.G.Gomez-Arroyo, L.Farkas, N.F.Voelkel: Inhibition of
focal adhesion kinase causes emphysema in rat lung, 2012 ATS International Conference, (San Francisco, '12.05)，
Am. J. Respir. Crit. Care Med., 185:A3752, 2012.

0310I003

K.Osanai, M.Zhou, T.Oikawa, K.Nakagawa, K.Tsuchihara, S.Mizuno, J.Huang, H.Toga: Exogenous expression oflysophosphatidylcholine acyltransferase 1 inhibits oxidant-induced alveolar type II celldeath in primary culture andameliorates oleic acid-induced acute lung injury in rats, 2012 FASEB Summer Conference, (Vermont, '12.07).

－ 30 －

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Associate Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Senior Assistant Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Senior Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Assistant Professor

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Assistant Professor

MATSUNAGA
Kazuhiro

Diserders of billary duct and pancreas

Assistant
Professor(Additional Post)

SAITO Takashi

Treament for metabolic syndrome

Faculty

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis－ 31 －

Publications
Originals
0320B001(T.Omori), Y.Kamiya, T.Tahara, T.Shibata, M.Nakamura, J.Yonemura, M.Okubo, D.Yoshioka, T.Ishizuka,
N.Maruyama, T.Kamano, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, T.Arisawa, I.Hirata: Correlation between
magnifying narrow band imaging and histopathology in gastric protruding/or polypoid lesions: a pilot feasibility
trial, BMC Gastroenterol., 12:17, 2012.

0320B002(T.Tahara), T.Shibata, M.Nakamura, J.Yonemura, M.Okubo, D.Yoshioka, Y.Kamiya, T.Arisawa, I.Hirata: Presenceof minimal change esophagitis closely correlates with pathological conditions in the stomach, Dig. Dis. Sci.,
57:958-966, 2012.

0320B003

T.Shibamoto, M.Tsutsumi, Y.Kuda, C.Ohmukai, W.Zhang, Y.Kurata: Mast cells are not involved in the ischemiareperfusion injury in perfused rat liver, J. Surg. Res., 174:114-119, 2012.

0320B004

H.Yamada, T.Tahara, H.Shiroeda, R.Hayashi, T.Saito, M.Nakamura, M.Tsuchishima, M.Tsutsumi, T.Shibata,T.Arisawa: Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy, J.
Gastrointestin. Liver Dis., 21:139-143, 2012.

0320B005

T.Arisawa, T.Tahara, H.Shiroeda, Y.Matsue, T.Minato, T.Nomura, H.Yamada, R.Hayashi, T.Saito, K.Matsunaga,
T.Fukuyama, N.Hayashi, T.Otsuka, A.Fukumura, M.Nakamura, T.Shibata: Genetic polymorphisms of IL17A andpri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer, Hum. Immunol., 73:747752, 2012.

0320B006

T.Arisawa, T.Tahara, M.Tsutsumi, T.Shibata: Influence of IL17A polymorphisms on the aberrant methylation of
DAPK and CDH1 in non-cancerous gastric mucosa, BMC Med. Genomics, 13:59, 2012.

0320B007

T.Arisawa, T.Tahara, K.Ozaki, Y.Matsue, T.Minato, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, A.Fukumura,
M.Nakamura, N.Toshikuni, H.Shiroeda, T.Shibata: Association between common genetic variant of HRH2 andgastric cancer risk, Int. J. Oncol., 41:497-503, 2012.

0320B008

T.Arisawa, T.Tahara, H.Shiroeda, H.Yamada, T.Nomura, R.Hayashi, T.Saito, T.Fukuyama, T.Otsuka,
M.Nakamura, N.Toshikuni, M.Tsuchishima, T.Shibata: NFKB1 polymorphism is associated with age-related gene
methylation in Helicobacter pylori-infected subjects, Int. J. Mol. Med., 30:255-262, 2012.

0320B009

R.Hayashi, T.Tahara, H.Shiroeda, Y.Matsue, T.Minato, T.Nomura, H.Yamada, T.Saito, K.Matsunaga,
T.Fukuyama, N.Hayashi, T.Otsuka, A.Fukumura, M.Nakamura, M.Tsutsumi, T.Shibata, T.Arisawa: Association ofgenetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases, J. Gastrointestin. Liver Dis., 21:243249, 2012.

0320B010

M.Nakamura, H.Shiroeda, T.Fukuyama, J.Yonemura, T.Shibata, T.Tahara, D.Yoshioka, M.Ohkubo, A.Kamatani,
Y.Katoh, I.Hirata, T.Arisawa: Combination chemotherapy with S-1 and docetaxel in advanced gastric cancer
patient with peritoneal dissemination and malignant ascites, Ann. Cancer Res. Ther., 20:7-10, 2012.

0320B011

T.Arisawa, T.Tahara, T.Fukuyama, R.Hayashi, K.Matsunaga, N.Hayashi, M.Nakamura, N.Toshikuni, H.Shiroeda,
T.Shibata: Genetic polymorphism of pri-microRNA 325, targeting SLC6A4 3'-UTR, is closely associated with therisk of functional dyspepsia in Japan, J. Gastroenterol., 47:1091-1098, 2012.

0320B012(T.Tahara), T.Shibata, M.Okubo, H.Yamashita, D.Yoshioka, J.Yonemura, N.Maruyama, T.Kamano, Y.Kamiya,
H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, H.Yamada, M.Nakamura, T.Arisawa, I.Hirata: Examination of serum
pepsinogen in functional dyspepsia, Hepatogastroenterology, 59:2516-2522, 2012.

0320B013(T.Tahara), T.Shibata, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Kamiya, T.Ishizuka, Y.Nakagawa,
M.Nagasaka, M.Iwata, M.Nakamura, I.Hirata, T.Arisawa: Synergistic effect of IL-1β and TNF-α polymorphisms
on the H. pylori-related gastric pre-malignant condition, Hepatogastroenterology, 59:2416-2420, 2012.

0320B014

R.Hayashi, T.Tahara, T.Yamaaki, T.Saito, K.Matsunaga, N.Hayashi, A.Fukumura, K.Ozaki, M.Nakamura,
H.Shiroeda, M.Tsutsumi, T.Shibata, T.Arisawa: -449 C>G polymorphism of NFKB1 gene, coding nuclear factorkappa-B, is associated with the susceptibility to ulcerative colitis, World J. Gastroenterol., 18:6981-6986, 2012.

Reviews－ 32 －

0320C001(T.Tahara), T.Arisawa: Potential usefulness of DNA methylation as a risk marker for digestive cancer associatedwith inflammation, Expert Rev. Mol. Diagn., 12:489-497, 2012.

Presentations at Conference
International Conference (Presentations)
0320I001

R.Hayashi, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, H.Yamada, T.Nomura, T.Saito, K.Matsunaga, N.Hayashi,
T.Otsuka, A.Fukumura, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi, T.Arisawa: The *910t>C
polymorphism of mafk gene is closely associated with the progression of chronic gastritis, Digestive Disease Week
2012, (San Diego, '12.05).

0320I002

N.Hayashi, H.Shiroeda, R.Hayashi, K.Matsunaga, A.Fukumura, K.Ozaki, T.Tahara, T.Shibata, T.Arisawa: Scn10agene polymorphism are closely associated with risk of functional dyspepsia in japan, Digestive Disease Week 2012,(San Diego, '12.05).

0320I003

H.Shiroeda, T.Tahara, R.Hayashi, N.Hayashi, K.Matsunaga, K.Ozaki, M.Nakamura, T.Shibata, T.Arisawa: Effectsof HRH2-1018 G>a polymorphism (rs2067474)on the progression of chronic gastritis, Digestive Disease Week
2012, (San Diego, '12.05).

0320I004

T.Arisawa, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, T.Saito, T.Fukuyama, N.Hayashi,
K.Matsunaga, T.Otsuka, A.Fukumura, K.Ozaki, M.Nakamura, N.Toshikuni, M.Tsuchishima, M.Tsutsumi: The 449c>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility toulcerative colitis, Digestive Disease Week 2012, (San Diego, '12.05).

0320I005

K.Matsunaga, T.Tahara, H.Shiroeda, R.Hayashi, N.Hayashi, K.Ozaki, M.Nakamura, T.Shibata, T.Arisawa: Apolymorphism rs7521584 in pre-mir429 and pre-mir200s genes is closely associated with the progression ofchronic gastritis, Digestive Disease Week 2012, (San Diego, '12.05).

0320I006

H.Shiroeda, T.Tahara, R.Hayashi, T.Minato, Y.Matsue, H.Yamada, T.Nomura, T.Saito, K.Matsunaga, N.Hayashi,
T.Otsuka, A.Fukumura, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Effects of -1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,on hypermrthylation of CDH1 gene in human gastricmucosa., Digestive Disease Week 2012, (San Diego, '12.05).

0320I007(M.Okubo), T.Shibata, T.Ichikawa, J.Yonemura, D.Yoshioka, T.Ishizuka, I.Hirata, T.Arisawa: Identification ofendosopic, histological, and serological markers,associated with dyspeptic symptoms., Digestive Disease Week
2012, (San Diego, '12.05).

0320I008(M.Okubo), T.Shibata, T.Tahara, Y.Ichikawa, J.Yonemura, D.Yoshioka, T.Ishizuka, I.Hirata, T.Arisawa:
Association between common functional genetic polymorphisms and survival of gastric cancer patients, Digestive
Disease Week 2012, (San Diego, '12.05).

0320I009(D.Yoshioka), T.Shibata, T.Tahara, Y.Ichikawa, J.Yonemura, M.Okubo, T.Ishizuka, I.Hirata, T.Arisawa: Telomera
length in non-neoplastic gastric mucosa and its relationship to H.pylori infection,Degree of gastritis and nonsterodal anti-inflammatory drugs(NSAIDs)use., Digestive Disease Week 2012, (San Diego, '12.05).

0320I010(T.Shibata), T.Tahara, T.arisawa, I.Hirata: A common polymorphism of serotonin receptor 1A gene is associatedwith functional dyspepsia in Japanese., Digestive Disease Week 2012, (San Diego, '12.05).

0320I011(J.Yonemura), T.Shibata, T.Tahara, Y.Ichikawa, M.Okubo, D.Yoshioka, T.Ishizuka, I.Hirata, T.Arisawa:
Association between common functional genetic polymorphisms predisposed to CpG island methylation in nonneoplastic gastric mucosa, Digestive Disease Week 2012, (San Diego, '12.05).

0320I012(Y.Ichikawa), T.Shibata, T.Tahara, J.Yonemura, M.Okubo, D.Yoshioka, T.Ishizuka, I.Hirata, T.Arisawa: Telomere
length in non-neoplastic colonic mucasa in ulcerative colitis and its relationship to the severe clinical phenotype,
Digestive Disease Week 2012, (San Diego, '12.05).

0320I013(D.Yoshioka), T.Shibata, T.Tahara, Y.Ichikawa, J.Yonemura, M.Okubo, T.Ishizuka, I.Hirata, T.Arisawa:
Association between common funtional genetic polymophisms and CpG island methylation status in colonic mucosa
in ulcerrative colitis, Digestive Disease Week 2012, (San Diego, '12.05).

－ 33 －

0320I014

N.Toshikuni, A.Fukumura, N.Hayashi, M.Tsuchishima, T.Arisawa, M.Tsutsumi: Comparion of the relationships ofalcoholic and nonalcoholic fatty liver with lifestyle-related diseases, 2012 ISBRA World Congress, (Sapporo,'12.09).

－ 34 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Senior Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Assistant Professor

ADACHI Hiroki

Clinical nephrology

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

Publications
Originals
0330B001

H.Yokoyama, T.Taguchi, H.Sugiyama, H.Sato: Membranous nephropathy in Japan: analysis of the Japan Renal
Biopsy Registry (J-RBR), Clin. Exp. Nephrol., 16:557-563, 2012.
－ 35 －

0330B002

T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami,
T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo: Glycogen synthase kinase 3βinhibition sensitizes
pancreatic cancer cells to gemcitabine, J. Gastroenterol., 47:321-333, 2012.

0330B003

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.

0330B004

Y.Noborisaka, M.Ishizaki, M.Nakata, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Cigarette smoking,proteinuria, and renal function in middle-aged Japanese men from an occupational population, Environ. HealthPrevent. Med., 17:147-156, 2012.

0330B005(M.Shimizu), M.Kuroda, N.Sakashita, M.Konishi, H.Kaneda, N.Igarashi, J.Yamahana, H.Taneichi, H.Kanegane,
M.Ito, S.Saito, K.Ohta, T.Taniguchi, K.Furuichi, T.Wada, M.Nakagawa, H.Yokoyama, A.Yachie: Cytokine profilesof patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome, Cytokine., 60:694700, 2012.

0330B006

S.Kimura, M.Asaka, H.Atsumi, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Okuyama, H.Yamaya,
H.Yokoyama: Circulating fibrocytes in ischemia-reperfusion injury and chronic renal allograft fibrosis, NephronClin. Pract., 121:c16-c24, 2012.

0330B007

H.Yokoyama, H.Sugiyama, H.Sato, T.Taguchi, M.Nagata, S.Matsuo, H.Makino, T.Watanabe, T.Saito, Y.Kiyohara,
S.Nishi, H.Iida, K.Morozumi, A.Fukatsu, T.Sasaki, K.Tsuruya, Y.Kohda, M.Higuchi, H.Kiyomoto, S.Goto,
M.Hattori, H.Hataya, S.Kagami, N.Yoshikawa, Y.Fukasawa, Y.Ueda, H.Kitamura, A.Shimizu, K.Oka, N.Nakagawa,
T.Ito, S.Uchida, K.Furuichi, I.Nakaya, S.Umemura, K.Hiromura, M.Yoshimura, N.Hirawa, T.Shigematsu,
M.Fukagawa, M.Hiramatsu,Y.Terada, O.Umemura, T.Kawata, A.Matsunaga, A.Kuroki, Y.Mori, K.Mitsuiki,
H.Yoshida: Renal disease in the elderly and the very elderly Japanese: analysis of the Japan Renal Biopsy Registry(J-RBR), Clin. Exp. Nephrol., 16:903-920, 2012.

0330B008

T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi: Characterization of proteinssecreted by pancreatic cancer cells with anticancer drug treatment in vitro, Oncol. Rep., 28:1968-1976, 2012.

Case Reports
0330D001

H.Okuyama, S.Kimura, K.Fujimoto, J.Imura, Y.Chikazawa, M.Nakagawa, H.Yamaya, H.Yokoyama: A case ofchronic hepatitis C with nephrotic diabetic nephropathy who achieved sustained viral remission by double-filtration
plasmapheresis and interferon combination therapy, Intern. Med., 51:1991-1995, 2012.

Short Communications
0330E001(K.Yanaga), N.Maekawa, N.Shimomura, Y.Ishigaki, Y.Nakamura, T.Takegami, N.Tomosugi, S.Miyazawa,
S.Kuwabata: Use of ionic liquid in fungal taxonomic study of ultrastructure of basidiospore ornamentation,
Mycological Prog., 11:343-347, 2012.

Presentations at Conference
International Conference (Synposium)
0330H001(R.Yamamoto), E.Imai, H.Yokoyama, S.Matsuo: Primary nephrotic syndrome in Japan: Japan Nephrotic Syndrome
Cohort Study (JNSCS), 1st Chronic Kidney Disease Frontier Meeting, (Nagoya, '12.02).

International Conference (Presentations)
0330I001

Y.Ishigaki, Y.Nakamura, T.Takehara, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Ionic liquid enables
simple and rapid sample preparation of human culturing cells for scanning electron microscope (SEM) analysis, 14th
International Congress of Histochemistry and Cytochemistry, (Kyoto, '12.08).

－ 36 －

0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Senior Assistant Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Assistant Professor

ITO Hiroki

diabetes

Research Doctor

WATANABE Ai

diabetes

Research Doctor

KANASAKI Megumi

diabetes, hypertension, obesity, preeclampsia

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001(N.Deji), S.Kume, S.Araki, K.Issiki, H.Araki, M.Chin-Kanasaki, Y.Tanaka, A.Nishiyama, D.Koya, M.Haneda,
A.Kashiwagi, H.Maegawa, T.Uzu: Role of angiotensin II-mediated AMPK inactivation on obesity-related saltsensitive hypertension, Biochem. Biophys. Res. Commun., 418:559-564, 2012.

0340B002(M.Aoyama), K.Issiki, S.Kume, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya, M.Haneda, A.Kashiwagi, H.Maegawa,T.Uzu: Fructose induces tubulointerstitial injury in the kidney of mice, Biochem. Biophys. Res. Commun.,
419:244-249, 2012.
－ 37 －

0340B003(T.Uzu), Y.Kida, A.Yamauchi, S.Kume, K.Isshiki, S.Araki, D.Koya, M.Haneda, A.Kashiwagi, H.Maegawa,
R.Kikkawa: The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without
overt proteinuria, J. Am. Soc. Hypertens., 6:124-131, 2012.

0340B004(M.Sawaguchi), S.Araki, H.Kobori, M.Urushihara, M.Haneda, D.Koya, A.Kashiwagi, T.Uzu, H.Maegawa:
Association between urinary angiotensinogen levels and renal and cardiovascular prognoses in patients with type 2
diabetes mellitus, J Diabetes Investig, 3:318-324, 2012.

0340B005

A.Takeda-Watanabe, M.Kitada, K.Kanasaki, D.Koya: SIRT1 inactivation induces inflammation through thedysregulation of autophagy in human THP-1 cells, Biochem. Biophys. Res. Commun., 427:191-196, 2012.

Reviews
0340C001(S.Kume), M.C.Thomas, D.Koya: Nutrient sensing, autophagy, and diabetic nephropathy, Diabetes, 61:23-29,
2012.

0340C002(T.B.Huber), C.L.Edelstein, B.Hartleben, K.Inoki, M.Jiang, D.Koya, S.Kume, W.Lieberthal, N.Pallet, A.Quiroga,
K.Ravichandran, K.Susztak, S.Yoshida, Z.Dong: Emerging role of autophagy in kidney function, diseases and aging,
Autophagy, 8:1009-1031, 2012.

0340C003

L.Xu, K.Kanasaki, M.Kitada, D.Koya: Diabetic angiopathy and angiogenic defects, Fibrogenesis Tissue Repair,
5:13, 2012.

0340C004

K.Kanasaki, M.Kitada, D.Koya: Pathophysiology of the aging kidney and therapeutic interventions, Hypertens.
Res., 35:1121-1128, 2012.

0340C005(S.Kume), T.Uzu, H.Maegawa, D.Koya: Autophagy: a novel therapeutic target for kidney diseases, Clin. Exp.
Nephrol., 16:827-832, 2012.

0340C006(Y.Tanaka), S.Kume, M.Kitada, K.Kanasaki, T.Uzu, H.Maegawa, D.Koya: Autophagy as a therapeutic target indiabetic nephropathy, Exp. Diabetes Res., e628978, 2012.

Presentations at Conference
International Conference (Synposium)
0340H001

D.Koya: Aging renal injury: SIRT1 and autophagy, The 33rd Naito Conference on Oxygen Biology: Hypoxia,
Oxidative Stress and Diseases, (Sapporo, Japan, '12.06)，"The 33rd Naito Conference on Oxygen Biology:
Hypoxia, Oxidative Stress and Diseases", 37-38, 2012.

0340H002

M.Kitada: S2 Clinical diabetes & therapeutics New therapeutic targets for diabetes S2-3 SIRT1 as a therapeutictarget fou type 2 diabetes, 2012 International Conference on Diabetes and Metabolism, (Seoul, Korea, '12.11)，
2012 International Conference on Diabetes and Metabolism, 20-21, 2012.

International Conference (Presentations)
0340I001

A.Takeda-Watanabe: SIRT1 inactivation induces inflammation through the dysregulation of autophagy in human
THP-1 cells, The 11th Japan-Korea Diabetic Nephropathy Seminar, (Kanazawa, Japan, '12.10)，The 11th JapanKorea Diabetic Nephropathy Seminar Program, 7, 2012.

0340I002

T.Nagai: Endogenous anti-fibrotic peptide N-acetyl-seryl-asparthl-lysyl-proline inhibits endothelial-mesenchymaltransition and diabetes-associated kidney fibrosis, The 11th Japan-Korea Diabetic Nephropathy Seminar,(Kanazawa, Japan, '12.10)，The 11th Japan-Korea Diabetic Nephropathy Seminar Program, 19, 2012.

0340I003

K.Kanasaki: Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis, The 11th JapanKorea Diabetic Nephropathy Seminar, (Kanazawa, Japan, '12.10)，The 11th Japan-Korea Diabetic Nephropathy
Seminar Program, 21, 2012.

－ 38 －

0340I004

A.Nakagawa, M.Nishizawa, S.Tsuda, S.Fujii, T.Seta, H.Takata, Y.Hiraiwa, H.Nakabayashi, D.Koya: Is sitagliptin
replaceable for sulfonylurea (SU) in type 2 diabetic patients treared with SU + metformin or pioglitazone?, 9thInternational Diabetes Federation Western Pacific Region Congress /4th Scientific Meeting of the Asian
Association for the Study of Diabetes, (Kyoto, Japan, '12.11)，J. Diabetes Investig., 3(Suppl.1):207, 2012.

0340I005

T.Nagai, K.Kanasaki, D.Koya: Endogenous anti-fibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline inhibits
endothelial-mesenchymal transition and diabetes-associated kidney fibrosis, American Society of Nephrology
Kidney Week 2012, (San Diego, CA, USA, '12.11).

0340I006

K.Kanasaki: Preeclampsia and metabolic syndrome; Possible shared molecular mechanisms, BIT's 1st International
Congress of Gynaecology and Obstetrics, (Guangzhou, China, '12.12).

－ 39 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Associate Professor

TANAKA Masao

Rheumatology, Immunology

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

MIKI Miyuki

Hematology and Immunology

Assistant Professor

IWAO Haruka

Hematology and Immunology

Assistant Professor

NAKAJIMA Akio

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
Studies of immunological abnormalities and pathophysiology of autoimmune diseases:
1 Effects of chemokines on vascular injury and Th1 response during chronic inflammation.
2 Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases.
3 Analysis of immunological disorder in sphingomyelin knockout mice.
4 Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis.
5 Detection of stem cells in salivary glands and its implication for regenerative medicine.
Studies of hematological malignancies and development of anti-cancer drugs:
1 Analysis of EB-virus proteins and their roles in lymphoproliferative disorders.
2 Molecular biological analysis of drug resistance.
3 Roles of sphingomyelin on apoptosis.
4 Roles of SMS on niche of leukemia stem cells.

Publications
Originals
0350B001

Y.Fujita, H.Yanagida, T.Mimori, Z.Jin, T.Sakai, T.Kawanami, T.Sawaki, Y.Masaki, T.Fukushima, T.Okazaki,
H.Umehara: Prevention of fasting-mediated bone marrow atrophy by leptin administration, Cell. Immunol., 273:5258, 2012.
－ 40 －

0350B002(N.Tomita), M.Yokoyama, W.Yamamoto, R.Watanabe, Y.Shimazu, Y.Masaki, S.Tsunoda, C.Hashimoto,
K.Murayama, T.Yano, R.Okamoto, A.Kikuchi, K.Tamura, K.Sato, K.Sunami, H.Shibayama, R.Takimoto,R.Ohshima, Y.Hatta, Y.Moriuchi, T.Kinoshita, M.Yamamoto, A.Numata, Y.Ishigatsubo, K.Takeuchi: Central
nervous system event in patients with diffuse large B-cell lymphoma in the rituximab era, Cancer Sci., 103:245251, 2012.

0350B003(E.Lafont), R.Dupont, N.Andrieu-Avadie, T.Okazaki, K.Schulze-Osthoff, T.Levade, H.Benoist, B.Séqui: Orderingof ceramide formation and caspase-9 activation in CD95L-induced jurkat leukemia T cell apoptosis, BBA-MOL
CELL BIOL L, 1821:684-693, 2012.

0350B004(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

0350B005(A.Malladi), E.Kenneth, S.Shiboski, C.Shiboski, A.Baer, R.Banushree, Y.Dong, P.Helin, B.Kirkham, M.Li, S.Sugai,
H.Umehara, V.Fredrick, C.Vollenweider, W..Zhang, Y.Zhao, J.Greenspan, T.Daniels, L.Criswell: Primary Sjögren's
syndrome as a systemic disease: a study of participants enrolled in an international Sjögren's syndrome registry,
ARTHRIT CARE RES, 64:911-918, 2012.

0350B006(S.Asano), K.Kitatani, M.Taniguchi, M.Hashimoto, K.Zama, S.Mitsutake, Y.Igarashi, H.Takeya, J.Kigawa,
A.Hayashi, H.Umehara, T.Okazaki: Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid
rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway, Mol. Cell. Biol., 32:3242-3252,
2012.

0350B007(L.Ping), N.Ogawa, Y.Zhang, S.Sugai, Y.Masaki, X.Weigou: p38 mitogen-activated protein kinase and nuclear
factor-kB facilitate CD40-mediated salivary epithelial cell death, J. Rheumatol., 39:1256-1264, 2012.

0350B008(N.Sugimoto), O.Shido, K.Matsuzaki, T.Ohno-Shosaku, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami,
Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara: Cellular heat acclimation regulates cell
growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse
fibroblast cells, Cell. Physiol. Biochem., 30:450-457, 2012.

0350B009(MH.Lu), M.Takemoto, K.Watanabe, H.Luo, M.Nishimura, M.Yano, H.Tomimoto, T.Okazaki, Y.Oike, WJ.Song:
Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice, J.
Physiol. (Lond.), 590:4029-4044, 2012.

0350B010(V.Deshpande), Y.Zen, J.Chan, E.Yi, Y.Sato, T.Yoshino, G.Klöppel, J.G.Heathcote, A.Khosroshahi, J.A.Ferry,
R.C.Aalberse, D.B.Bloch, W.R.Brugge, A.C.Bateman, M.N.Carruthers, S.T.Chari, W.Cheuk, L.D.Cornell,
C.FD.Castillo, D.G.Forcione, D.L.Hamilos, T.Kamisawa, S.Kasashima, S.Kawa, M.Kawano, G.Y.Lauwers,
Y.Masaki, Y.Nakamura, K.Notohara, K.Okazaki, J.K.Ryu, T.Saeki, D.V.Sahani, T.C.Smyrk, J.R.Stone, M.Takahira,
G.J.Webster, M.Yamamoto, G.Zamboni, H.Umehara, J.H.Stone: Consensus statement on the pathology of IgG4related disease, Mod. Pathol., 25:1181-1192, 2012.

0350B011(K.Zama), A.Mitsutake, K.Watanabe, T.Okazaki, Y.Igarashi: A sensitive cell-based method to screen for selective
inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate, Chem. Phys. Lipids, 165:760-768, 2012.

0350B012(I.Mizushima), K.Yamada, H.Fujii, D.Inoue, H.Umehara, M.Yamagishi, Y.Yamaguchi, M.Nagata, M.Matsumura,
M.Kawano: Clinical and histological changes associated with corticosteroid therapy in IgG4-related
tubulointerstitial nephritis, Mod. Rheumatol., 22:859-870, 2012.

0350B013

T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, T.Nakamura, T.Sato, Y.Fujita, M.Tanaka, Y.Masaki,
T.Fukushima, Y.Hirose, M.Taniguchi, N.Sugimoto, T.Okazaki, H.Umehara: Skewed production of IL-6 and TGFβ
by cultured salivary gland epithelial cells from patients with Sjögren's syndrome, PLoS ONE, 7:e45689 1-5, 2012.

0350B014

M.Taniguchi, K.Kitatani, T.Kondo, M.Hashimoto-Nishimura, S.Asano, A.Hayashi, S.Mitsutake, Y.Igarashi,
H.Umehara, H.Takeya, J.Kigawa, T.Okazaki: Regulation of autophagy and its associated cell death by sphingolipid
rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway., J. Biol. Chem.,
287:39898-39910, 2012.

0350B015

H.Umehara, K.Okazaki, Y.Masaki, M.Kawano, M.Yamamoto, T.Saeki, S.Matsui, T.Yoshino, S.Nakamura, S.Kawa,
H.Hamano, T.Kamisawa, T.Shimosegawa, A.Shimatsu, S.Nakamura, T.Ito, K.Notohara, T.Sumida, Y.Tanaka,
T.Mimori, T.Chiba, M.Mishima, T.Hibi, H.Tsubouchi, K.Inui, H.Ohara: Comprehensive diagnostic criteria for
IgG4-related disease(IgG4-RD), 2011, Mod. Rheumatol., 22:21-30, 2012.
－ 41 －

0350B016

L.Dong, K.Watanabe, M.Itoh, C.Huan, X.Tong, T.Nakamura, M.Miki, H.Iwao, A.Nakajima, T.Sakai, T.Kawanami,
T.Sawaki, Y.Masaki, T.Fukushima, Y.Fujita, M.Tanaka, M.Yano, T.Okazaki, H.Umehara: CD4＋T-cell
dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin syｎthase 1-knockout mice, Int. Immunol., 24:327-337, 2012.

0350B017

T.Fukushima, Y.Urasaki, M.Yamaguchi, M.Ueda, K.Morinaga, T.Haba, T.Sugiyama, S.Nakao, H.Origasa,
H.Umehara, T.Ueda: A randomized comparison of modified intermediate-dose Ara-C versus high-dose Ara-C inpost-remission therapy for acute myeloid leukemia, Anticancer Res., 32:643-648, 2012.

0350B018(K.Murakami), M.Tanaka, T.Usui, D.Kawabata, A.Shiomi, M.Iguchi-Hashimoto, M.Shimizu, N.Yukawa, H.Yoshifuji,
T.Nojima, K.Ohmura, T.Fujii, H.Umehara, T.Mimori: Follistatin-related protein/follistatin-like 1 evokes an innate
immune response via CD14 and toll-like receptor 4, FEBS Lett., 586:319-324, 2012.

0350B019(S.C.Shiboski), C.H.Shiboski, L.Criswell, A.Baer, S.Challacombe, H.Lanfranchi, M.Schiødt, H.Umehara, F.Vivino,
Y.Zhao, Y.Dong, D.Greenspan, A.M.Heidenreich, P.Helin, B.Kirkham, K.Kitagawa, G.Larkin, M.Li, T.Lietman,
J.Lindegaard, N.McNamara, K.Sack, P.Shirlaw, S.Sugai, C.Vollenweider, J.Whitcher, A.Wu, S.Zhang, W.Zhang,
J.Greenspan, T.Daniels: American college of rheumatology classification criteria for Sjögren's syndrome: a datadriven, expert consensus approach in the Sjögren's international collaborative clinical alliance cohort, ARTHRITCARE RES, 64:475-487, 2012.

0350B020

Y.Masaki, N.Kurose, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada, S.Matsui, T.Origuchi, S.Nishiyama,
K.Yamada, M.Kawano, A.Hirabayashi, K.Fujikawa, T.Sugiura, M.Horikoshi, N.Umeda, H.Minato, T.Nakamura,
H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.sawaki, T.Kawanami, Y.Fujita, M.Tanaka, T.Fukushima, K.Eguchi,
S.Sugai, H.Umehara: Cutoff values of serum IgG4 and histopathological IgG4+ plasma cells for diagnosis of patientswith IgG4-related disease, Int. J. Rheumatol., e580814,1-5, 2012.

0350B021(M.Kawano), I.Mizushima, Y.Yamaguchi, N.Imai, H.Nakashima, S.Nishi, S.Hisano, N.Yamanaka, M.Yamamoto,
H.Takahashi, H.Umehara, T.Saito, T.Saeki: Immunohistochemical characteristics of IgG4-related tubulointerstitialnephritis: detailed analysis of 20 Japanese cases, Int. J. Rheumatol., e609795, 2012.

0350B022(A.Takami), S.Ohtake, E.Morishita, Y.Terasaki, T.Fukushima, T.Kurokawa, N.Sugimori, S.Matano, K.Ohata,
C.Saito, M.Yamaguchi, K.Hosokawa, H.Yamazaki, Y.Kondo, S.Nakano: Late response to low-dose imatinib inpatients with chronic phase chronic myeloid leukemia, Int. J. Hematol., 96:357-363, 2012.

Reviews
0350C001(J.H.Stone), A.Khosroshahi, V.Deshpande, J.K.Chan, J.G.Heathcote, R.Aalberse, A.Azumi, D.B.Bloch,
W.R.Brugge, M.N.Carruthers, W.Cheuk, L.Cornell, C.F.Castillo, J.A.Ferry, D.Forcione, G.Klöppel, D.L.Hamilos,
T.Kamisawa, S.Kasashima, S.Kawa, M.Kawano, Y.Masaki, K.Notohara, K.Okazaki, J.K.Ryu, T.Saeki, D.Sahani,
Y.Sato, T.Smyrk, J.R.Stone, M.Takahira,, H.Umehara, G.Webster, M.Yamamoto, E.Yi, T.Yoshino, G.Zamboni,
Y.Zen, S.Chari: Recommendations for the nomenclature of IgG4-related disease and its individual organ systemmanifestations, Arthritis Rheum, 64:3061-3067, 2012.

0350C002

H.Umehara, K.Okazaki, Y.Masaki, M.Kawano, M.Yamamoto, T.Saeki, S.Matsui, T.Sumida, T.Mimori, Y.Tanaka,
K.Tsubota, T.Yoshino, S.Kawa, R.Suzuki, T.Takegami, N.Tomosugi, N.Kurose, Y.Ishigaki, A.Azumi, M.Kojima,
S.Nakamura, D.Inoue: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details, Mod.
Rheumatol., 22:1-14, 2012.

0350C003(K.Okazaki), H.Umehara: Are classification criteria for IgG4-RD now possible? The concept of IgG4-Relateddisease and proposal of comprehensive diagnostic criteria in Japan, Int. J. Rheumatol., e357071, 2012.

Case Reports
0350D001

T.Fukushima, H.Kawabata, T.Sawaki, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, M.Miki, Y.Fujita,
M.Tanaka, T.Kawanami, Y.Masaki, T.Okazaki, H.Umehara: Low-dose cytarabine plus aclarubicin for patients withpreviously untreated acute myeloid leukemia or high-risk myelodysplastic syndrome ineligible for standard-dose
cytarabine plus anthracline, Anticancer Res., 32:1347-1354, 2012.

－ 42 －

0350D002

T.Fukushima, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, Y.Masaki, T.Okazaki, H.Nakajima, Y.Motoo, H.Umehara: Daily 500mg valacyclovir is effective forprevention of varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib,
Anticancer Res., 32:5437-5440, 2012.

0350D003

T.Fukushima, HH.Iwao, T.Sakai, T.Sato, T.Nakamura, A.Nakajima, M.Miki, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, H.Umehara: Once-weekly bortezomib plus dexamethasone therapy induced complete response, reducing
severe gastrointestinal adverse events for a patient with relapsed multiple myeloma -a case report, Cancer &chemotherapy, 39:805-807, 2012 (in Japanese) .

Others
0350F001

H.Umehara: A new clinical entity: IgG4-related disease (IgG4-RD) discovered in the 21st century, Intern. Med.,
51:821-822, 2012.

Presentations at Conference
International Conference (Synposium)
0350H001

T.Okazaki: Hot Topics in Sphingolipid metabolism, Gordon Research Conferences in 2012, Glycolipid&Sphingolipid Biology, (Barga/Italy, '12.04).

0350H002

T.Okazaki: Sphingosine-1-phosphate/S1P3 counteracts ceramide-induced autophagy-associated cell deaththrough mTOR pathway in leukemia cells, 53rd International Conference on the Bioscience of Lipids(ICBL),(Banff/Canada, '12.09).

0350H003

T.Okazaki: Thrombocytopenia caused by sphingomyelin synthase 1 (SMS1) deficiency in mice, EMBO Molecular
Medicine Workshop 2012, (Ramot/Israel, '12.10).

－ 43 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TOMIOKA Ryo

Clinical neurology, Neuroimmunology

Senior Assistant Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

NAKATA Michiyo

Clinical neurology

Assistant Professor

MINATO Naomi

Clinical neurology

Assistant Professor

KITAMURA Akihiro

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001

Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato: Suppression of synaptic
plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients, Neurobiol. Dis., 45:610-615,
2012.

0360B002(T.Kezuka), Y.Usui, N.Yamakawa, Y.Matsunaga, R.Matsuda, M.Masuda, H.Utsumi, K.Tanaka, H.Goto:
Relationship between NMO-Antibody and Anti-MOG Antibody in optic neuritis, J. Neuroophthalmol., 32:107-110,
2012.

0360B003(A.Nagaishi), T.Tani, M.Takagi, M.Tanaka, K.Sakimura, M.Matsui, K.Tanaka: Anti-aquaporin 4 antibody binding
character in clinical subtypes of neuromyelitis optica, Clin. Exp. Neuroimmunol., 3:109-115, 2012.

0360B004(K.Takahashi), K.Tanaka: Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive
antibodies in Ishikawa prefecture,Japan, J. Neuroimmunol., 250:111-114, 2012.

0360B005(K.Fujita), T.Yuasa, Y.Takahashi, K.Tanaka, S.Hashiguchi, K.Adachi, Y.Izumi, R.Kaji: Detection of anti-glutamate
receptor ε2 and anti-N-methyl-D-aspartate receptor antibodies in a patient with sporadic creutzfeldt-jakob
disease, J. Neurol., 259:985-988, 2012.

－ 44 －

0360B006(M.Yoshimura), K.Monma, N.Suzuki, M.Aoki, T.Kumamoto, K.Tanaka, H.Tomimitsu, S.Nakano, M.Sonoo,
J.Shimizu, K.Sugie, H.Nakamura, Y.Oya, Y.Hayashi, M.C.V.Malicdan, S.Noguchi, M.Murata, I.Nishino:
Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene
result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain
mutations, J. Neurol. Sci., 318:100-105, 2012.

0360B007(K.Fujita), T.Yuasa, Y.Takahashi, K.Tanaka, W.Sako, H.Koizumi, Y.Iwasaki, M.Yoshida, Y.Izumi, R.Kaji:
Antibodies to N-methyl-D-aspartate glutamate receptors in creutzfeldt-jakob disease patients, J. Neuroimmunol.,
251:90-93, 2012.

0360B008(K.Tsutsui), T.Kanbayashi, K.Tanaka, S.Boku, W.Ito, J.Tokunaga, A.Mori, Y.Hishikawa, T.Shimizu, S.Nishino:Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features,
BMC psychiatry, 12:37 ,1-9, 2012.

0360B009(Y.Ando), H.Shimazaki, M.Sawada, K.Yoshida, S.Sakamoto, K.Tanaka, I.Nakano: An Anti-NMDA-R
encephalitis/encephalopathy that was diagnosed as catatonia -An 18-year-old man with effective modified
electroconvulsive therapy-, Neurol Therap, 29:767-771, 2012 (in Japanese) .

0360B010(M.Tanaka), R.Motoyama, M.Tahara, K.Tanaka: Brain MRI findings in Japanese patients with clinically isolated
syndrome, Clinical Neurology, 52:725-729, 2012 (in Japanese) .

Reviews
0360C002

S.Nagayama, M.Matsui: Therapy for neuroimmunological diseases -standard treatment options and recent findings
for multiple sclerosis and neuromyelitis optica, Neurol Therap, 29:11-14, 2012 (in Japanese) .

Case Reports
0360D001(A.Uruha), Y.Kitazawa, M.Kuroda, K.Tanaka, R.Koide: Anti-NMDAR encephalitis in small-cell lung cancer: A casereport, Clin. Neurol. Neurosurg., 114:260-261, 2012.

0360D002(Y.Ariizumi), T.Ozawa, T.Tokutake, I.Kawachi, M.Hirose, S.Katada, S.Igarashi, K.Tanaka, M.Nishizawa: Chorea as
the first sign in a patient with elderly onset systemic lupus erythematosus, Case Report. Neurol. Med., 317082 ,13, 2012.

0360D003(T.Shirafuji), F.Kanda, K.Sekiguchi, M.Higuchi, H.Yokozaki, K.Tanaka, H.Takahashi, T.Toda: A case of Anti-Huassociated paraneoplastic encephalomyelitis with esophageal small cell carcinoma, Intern. Med., 51:2423-2427,
2012.

0360D004

S.Nagayama, N.Minato, M.Nakata, M.Kaito, M.Nakanishi, K.Tanaka, M.Arai, H.Akiyama, M.Matsui: Novel FUS
mutation in patients with sporadic amyotrophic lateral sclerosis and corticobasal degeneration, J. Clin. Neurosci.,
19:1738-1739, 2012.

0360D006(Y.Takado), T.Shimohata, I.Kawauchi, K.Tanaka, M.Nishizawa: Successful treatment of neuroborreliosis withcombined administration of antibiotics and steroids : A case report, Clinical Neurology, 52:411-415, 2012 (inJapanese) .

0360D007(A.Kubota), T.Tajima, S.Narukawa, M.Yamazato, H.Fukaura, Y.Takahashi, K.Tanaka, J.Shimizu, K.Nomura: AntiMa2, anti-NMDA-receptor and anti-GluRε2 limbic encephalitis with testicular seminoma: short-term memory
disturbance, Clinical Neurology, 52:666-671, 2012 (in Japanese) .

0360D008(K.Tsutsui), T.Kanbayashi, K.Tanaka, S.Boku, W.Ito, J.Tokunaga, A.Mori, Y.Hishikawa, T.Shimizu, S.Nishino:Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features,
Jpn. J. Gen. Hosp. Psychiatry, 24:40-50, 2012 (in Japanese) .

Others0360F001(M.Tahara), R.Ito, K.Tanaka, M.Tanaka: Cortical and leptomeningeal involvement in three cases of neuromyelitis
optica, Eur. J. Neurol., 19:47-48, 2012.

－ 45 －

Presentations at Conference
International Conference (Synposium)
0360H001

K.Tanaka, A.Nagaishi, M.Takagi, A.Uemura, M.Tanaka, M.Matsui, M.Nishizawa, K.Sakimura: A large Japanesecohort study for AQP4 antibody-positive cases, Fifth Congress of the Pan-Asian Committee, (Beijing, '12.09).

International Conference (Presentations)
0360I001

M.Matsui, S.Araya, F.Hoashi, M.Nakanishi, S.Nagayama: Amelioration of Experimental Autoimmune
Encephalomyelitis with Oral Administration of Traditional Japanese Herbal Medicine, 11 th International Congress of
Neuroimmunology, (Boston, '12.11).

0360I002

K.Tanaka, Y.Li, Y.Ishigaki, T.Takegami, M.Tanaka, M.Matsui, N.Kato: Effects of anti-NMDA receptor antibodies
from the patients with NMDA receptor encephalitis on the neurons, 11th International Congress of
Neuroimmunology, (Boston, '12.11).

－ 46 －

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Senior Assistant Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

NAKAYA Naoki

Medical Oncology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Books
0363A002

Y.Motoo, QS.Xia, N.Nakaya, T.Shimasaki, H.Nakajima: Stress responses of pancreatic cancer cells and theirsignificance in invasion and metastasis, The Primo Vascular System: Its Role in Cancer and Regeneration, 213-217,
Springer, New York, 2012.

0363A003(T.Minamoto), M.Kotake, M.Nakada, T.Shimasaki, Y.Motoo, Kawakami K: Distinct pathologic role for glycogensynthase kinase 3β in colorectal cancer progression, Colorectal cancer biology – from genes to tumor, 107-134,
InTech, Croatia, 2012.

Publications
Originals
0363B001

T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami,
T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo: Glycogen synthase kinase 3βinhibition sensitizes
pancreatic cancer cells to gemcitabine, J. Gastroenterol., 47:321-333, 2012.

0363B002

I.Sato, N.Nakaya, T.Shimasaki, H.Nakajima, Y.Motoo: Prediction of docetaxel monotherapy-induced neutropenia
based on the monocyte percentage, Oncol. Lett., 3:860-864, 2012.

0363B003(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

0363B004

T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi: Characterization of proteinssecreted by pancreatic cancer cells with anticancer drug treatment in vitro, Oncol. Rep., 28:1968-1976, 2012.

Reviews－ 47 －

0363C001

Y.Motoo: Traditional Japanese medicine in the multi-disciplinary approach to cancer, J. Trad. Med., 29:104-107,
2012.

0363C002

T.Shimasaki, A.kitano, Y.Motoo, T.Minamoto: Aberrant glycogen synthase kinase 3β in the development ofpancreatic cancer, J. Carcinog., 11:15 ,1-9, 2012.

Case Reports
0363D001

T.Fukushima, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, Y.Masaki, T.Okazaki, H.Nakajima, Y.Motoo, H.Umehara: Daily 500mg valacyclovir is effective forprevention of varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib,
Anticancer Res., 32:5437-5440, 2012.

Presentations at Conference
International Conference (Presentations)
0363I001

J.Yamakawa, Y.Ishigaki, J.Moriya, Y.Motoo, T.Takegami, J.Kobayashi: The Kampo Medicenes Have Diffierent
Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes, 13th International Congress of
the Society for Ethnopharmacology, (Austria, '12.08).

－ 48 －

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

BABA Hisashi

Clinical Infectious Diseases, Infection Control and Prevention,
Clinical Microbiology

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001(Y.Matsumura), Y.Ito, Y.Iinuma, K.Yasuma, M.Yamamoto, A.Matsushima, M.Nagao, S.Takakura, S.Ichiyama:
Quantitative real-time PCR and the (1→3)-β-D-glucan assay for differentiation between Pneumocystis jirovecii
pneumonia and colonization, Clin. Microbiol. Infect., 18:591-597, 2012.

0366B002(A.Matsushima), S.Takakura, M.Yamamoto, Y.Matsumura, M.Shirano, M.Nagao, Y.Ito, Y.Iinuma, T.Shimizu,
N.Fujita, S.Ichiyama: Regional spread and control of vancomycin-resistant Enterococcus faecium and Enterococcus
faecalis in Kyoto, Japan, Eur. J. Clin. Microbiol. Infect. Dis., 31:1095-1100, 2012.

0366B003(Y.Hayashi), V.L.Vaska, H.Baba, G.R.Nimmo, L.Davis, D.L.Paterson: Influenza-associated bacterial pathogens inpatients with 2009 influenza A (H1N1) infection: impact of community-associated methicillin-resistant
Staphylococcus aureus in Queensland, Australia, Intern. Med. J., 42:755-760, 2012.

0366B004

N.Yoshino, Y.Asai, K.Enda, Y.Iinuma: Fundamental study of Chemiluminescent enzyme immunoassay measurement
reagent "Lumipulse HBeAb-N", Igakukensa, 61:594-599, 2012 (in Japanese) .

0366B005

A.Kumagai, M.Heinai, Y.Wada, H.Baba, Y.Iinuma: Effectiveness of waterless presurgical antisepsis with 1.0w/v%
chlorhexidine gluconate-alcohol-based hand rub : comparison with two-stage method, Japanese Journal ofEnvironmental Infections, 27:375-379, 2012 (in Japanese) .

Reviews
0366C001

Y.Iinuma: Enterococcus, Japanese Journal of Clinical Medicine, 70:213-218, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)－ 49 －

0366I001

H.Baba, M.Suzuki, Y.Iinuma: Investigation of the Clonality of Community-Associated Methicillin-Resistant

Staphylococcus aureus in Ishikawa Prefecture of Japan by Using Phage-Derived Open Reading Frames Typing,
IDWeek 2012, (San Diego, '12.10).

－ 50 －

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Associate Professor

ASAJI Takayoshi

Heart failure

Senior Assistant Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology

Senior Assistant Professor

YAMAKAWA Junichi

General medicine, Kampo medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Assistant Professor

HAYASAKI Hisae

lifestyle-related disease

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Books
0368A001

J.Yamakawa: Efficacy evaluation of Kanpo Medicine in a mouse model of chronic fatigue syndrome, Traditional
Medicene:New Reseach, 83-122, Nova Science Publishers, America, 2012.

0368A002

J.Yamakawa: Efficacy evaluation of Kampo Medicine in a mouse model of chronic fatigue syndrome, Traditional
Medicene:New Resarch, 7x10(NBC-C), Nova Publishers, America, 2012.

Presentations at Conference
International Conference (Presentations)
0368I001

J.Yamakawa, Y.Ishigaki, J.Moriya, Y.Motoo, T.Takegami, J.Kobayashi: The Kampo Medicenes Have Diffierent
Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes, 13th International Congress of
the Society for Ethnopharmacology, (Austria, '12.08).

－ 51 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Professor(Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

HIGASHIKAWA
Toshihiro

Geriatrics, Circulation

Research Doctor

TAKATA MeikoGeriatrics

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

K.Ishigami, M.Okuro, Y.Koizumi, K.Satoh, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association ofsevere hypertension with pneumonia in elderly patients with acute ischemic stroke, Hypertens. Res., 35:648-653,
2012.

0370B002

S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi,
H.Toga: Sleep apnoea syndrome as a risk for mortality in elderly inpatients, J. Int. Med. Res., 40:601-611, 2012.

0370B003

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, H.Nakagawa: Relationship between participation in asecondary screening test for the frail elderly and new onset of the need for long-term care among the elderly in arural town, Japanese Journal of Public Health., 59:801-809, 2012 (in Japanese) .

Reviews
0370C003

M.Okuro, S.Morimoto: Locomotive syndrome and Frailty. Vitamin D and Frailty., Clin. Calcium, 22:535-542, 2012
(in Japanese) .

－ 52 －

Others
0370F001(T.Takahashi), S.Matsumoto, K.Iijima, S.Morimoto: Guidelines for nonmedical care providers to manage the firststep of emergency triage of elderly evacuees: Downloaded via smart phones in Japan☆, J. Exp. Clin. Med., 4:296297, 2012.

Presentations at Conference
International Conference (Presentations)
0370I001(Y.Sagawa), N.Hirai, S.Sato, M.Sato, M.Okuro, T.Kanbayashi, T.Shimizu, S.Nishino: Noninvasive detection of
sleep/wake changes in orexin/ataxin-3 genic narcoleptic mice across the disease onset., 26th AssociatedProfessional Sleep Societies, (Boston, '12.06)，SLEEP 2012 26th Annual of the Associated Professional Sleep
Societies Abstract, 35：A76 (Suppl.), 2012.

0370I002

K.Iwai, S.Morimoto: CTCF is indispensable for the gene expression of estrogen receptors in the arterial smoothmuscle cell: Defensive mechanism against arteriosclerosis, American Heart Association Scientific Sessions 2012,(Los Angeles, '12.11)，American Heart Association Scientific Sessions 2012 Final Proguram, 201, 2012.

0370I003

M.Okuro, K.Tabuchi, T.C.Sudhof, S.Nishino: Deficiency of synaptic cell-adhesion molecule neurexin-3, and wakepromoting response to amphetamine, The 7th Asian Sleep Research Society Congress, (Taiwan, '12.11)，The 7th
Asian Sleep Research Society Congress Proguram, 30：51, 2012.

－ 53 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITO Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

KOBAYASHI Azusa

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

KITAOKA Chika

Pediatric cardiology

Assistant Professor

YAMASHITA Yoko

Pediatric allergy, Pediatric immunology.

Assistant Professor

OGURI Masato

Pediatric cardiology.

Assistant Professor

MUKAIYAMA
Hirotaka

Pediatric allergy, Pediatric immunology.

Research Doctor

KITO Toshiyuki

Pediatric allergy, Pediatric immunology

Research Doctor

YAMAMOTO Akiko

Child neurology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism
Neonatology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(A.Okumura), M.Uematsu, G.Imataka, M.Tanaka, T.Okanishi, T.Kubota, A.Sudo, J.Tohyama, M.Tsuji, I.Ohmori,
M.Naiki, A.Hiraiwa-Sofue, H.Sato, S.Saitoh, T.Shimizu: Acute encephalopathy in children with Dravet syndrome,
Epilepsia, 53:79–86, 2012.

0380B002(M.Shimizu), T.Yokoyama, N.Sakashita, A.Sato, K.Ueno, C.Akita, K.Ohta, E.Kitano, M.Hatanaka, H.Kitamura,
Y.Saikawa, A.Yachie: Thomsen-friedenreich antigen exposure as a cause of Streptococcus pyogenes-associatedhemolytic-uremic syndrome, Clin. Nephrol., 78:328-331, 2012.

－ 54 －

0380B003(A.Sakurai), M.Yamazaki, S.Suzuki, T.Fukushima, T.Imai, T.Kikumori, T.Okamoto, K.Horiuchi, S.Uchino,
S.Kosugi, M.Yamada, I.Komoto, K.Hanazaki, M.Itoh, T.Kondo, M.Mihara, M.Imamura: Clinical features of
insulinoma in patients with multiple endocrine neoplasia type 1: analysis of the database of the MEN Consortium ofJapan, Endocr. J., 59:859-866, 2012.

0380B004

A.Sakai, H.Mukoyama, A.Horiguchi, H.Shiga, T.Miwa: A case of Kawasaki disease with suspected peritionsillitis
and acute suppurative cervical lymphadenitis, Stomato-pharyngology / Japan Society of Stomato-pharyngology.,
25:73-78, 2012 (in Japanese) .

Reviews
0380C001

T.Akai, H.Iizuka, M.Yamashita, S.Kawakami, H.Satoh, Y.Saikawa: Craniosynostosis－Symptoms, diagnosis,
operation methods, and characteristics of patients treated at Kanazawa Medical University－, J. Kanazawa. Med.
Univ., 37:162-169, 2012 (in Japanese) .

Others0380F001(C.Tanaka), M.Hasegawa, M.Fujimoto, K.Iwatsuki, T.Yamamoto, K.Yamada, K.Kawa, Y.Saikawa, A.Toga, S.Mase,
T.Wada, K.Takehara, A.Yachie: Phenotypic analysis in a case of hydroa vacciniforme-like eruptions associatedwith chronic active Epstein-Barr virus disease of γδ T cells., Br. J. Dermatol., 166:216-8, 2012.

Presentations at Conference
International Conference (Presentations)
0380I001

T.Nakamura, M.Oguri, k.Tamanuki, C.Akita, C.Kitaoka, Y.Saikawa: A Convenient Method of Estimating Carotid
Arterial Stiffness in Children after Kawasaki Disease, The 10th International Kawasaki Disease Symposium, (Kyoto,'12.02).

－ 55 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Professor

KUBOTA Takashi

Schizophrenia, Psychopharmacology, Epilepsy

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Senior Assistant Professor

MONKAWA Akikazu

Brain imaging, Schizophrenia

Senior Assistant Professor

MONKAWA Tomomi

Psychopharmacology, Neuropsychology

Assistant Professor

KOSEKI Yojyu

Brain imaging

Assistant Professor

SHOU Masaya

Psychopharmacology

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001(X.Li), J.Jiao, S.Shimizu, I.Jibiki, K.Watanabe, T.Kubota: Correlations between atrophy of the entorhinal cortex
and cognitive function in patients with Alzheimer’s disease and mild cognitive impairment, Psychiatry Clin.
Neurosci., 66:587-593, 2012.

0390B003

Y.Matsuda, J.Tayama: Influence of 'Persistence' on Changing Moods of Peer Support, Japanese Society ofPsychosomatic Medicine., 52:396-404, 2012 (in Japanese) .

0390B004

Y.Matsuda, J.Tayama: Development of the Self-Other Focused Thinking Error Scale (SOFT) in
Depression(Symposium/How Can Psychotherapy Exercise Its Power to Move the Society Forward?), JapaneseSociety of Psychosomatic Medicine., 52:835-844, 2012 (in Japanese) .

－ 56 －

Reviews
0390C001

Y.Kawasaki, M.Suzuki: Voxel-based Morphometry as a Promising Tool for the Diagnosis of Schizophrenia, J. J. M.
R. M., 32:41-47, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0390I001

Y.Matsuda, Y.Kawasaki, T.Takahashi, M.Kido, K.Nakamura, A.Furuichi, M.Suzuki: Longitudinal changes of whitematter volume in first episode schizophrenia: A voxel-based morphometric analysis, 3rd Biennial Schizophrenia
International Research Society Conference Schizophrenia, (Firenze, '12.04).

0390I002

Y.Kawasaki, Y.Matsuda, T.Kubota, M.Kido, K.Nakamura, A.Furuichi, M.Suzuki: Longitudinal voxel-based
morphometric study examining progressive gray mater changes in first-episode schizophrenia, 3rd Biennial
Schizophrenia International Research Society Conference Schizophrenia, (Firenze, '12.04).

0390I003(H.Koizumi), K.Watanabe, Y.Kawasaki: Functional MRI study on effects of cognitive-behavioral therapy in patientswith OCD:neuronal activation during memory task, 42th EABCT Annual Congress, (Swiss Confederation, '12.09).

－ 57 －

0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

WATANABE Naoto

Nuclear Medicine

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

Associate Professor

TANIGUCHI Mitsuru Cardiac Nuclear Medicine

Associate
Professor(Additional Post)

KUGINUKI Yasuaki

Assistant Professor

KITADATE Masataka Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Assistant
Professor(Additional Post)

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

KOMINAMI Yoshiki

Diagnostic Imaging

Assistant Professor

FUJIMOTO Naoko

Diagnostic Imaging

Assistant
Professor(Additional Post)OTA Kiyotaka

Radiation Therapy

Diagnostic Imaging

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

K.Miyazawa, M.Matoba, H.Minato, N.Morita, I.Chikazawa, K.Ota, K.Tokunaga, H.Tonami, T.Nojima, K.Suzuki:
Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its
incidence and risk factors, Jpn. J. Radiol., 30:635-641, 2012.

－ 58 －

Presentations at Conference
International Conference (Presentations)
0400I001

M.Kitadate, T.Shibamoto, H.Tonami: Hepatic angiographic study in rat anaphylactic shock, 7th Congress of theInternational Federation of Shock Societies, (Florida (USA), '12.06)，Shock, 37 Suppl1:94, 2012.

0400I002

K.Miyazawa, D.Nakai, N.Morita, I.Chikazawa, K.Suga, M.Moriyama, T.Tanaka, K.Suzuki, M.Matoba, H.Minato:
Analysis of incidence and risk factor of seed migration after transperineal interstitial prostate brachytherapy with I125 free seeds, The 32nd Congress of the Societe Internationaled Urologie, (Fukuoka, '12.10).

－ 59 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

KAWAHIRA Yoichi

congenital heart surgery

Professor

SHIKATA Hiroo

Vascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Senior Assistant Professor

OKADA Masaho

Cardiovascular surgery

Senior Assistant Professor

KOBATA Takashi

Vascular surgery

Assistant Professor

NISHIZAWA Hisateru Cardiovascular surgery

Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Assistant Professor

MIKAMI Naofusa

Cardiovascular surgery

Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of patient-specific cardiac supporting net for dilated heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Publications
Originals
0410B001

F.Mizuno: Attenuation of Left Ventricular Dilatation (Remodeling) with a Cardiac Support Devicefollowing Acute
Myocardial Infarction in Dogs, J. Kanazawa. Med. Univ., 37:1-8, 2012 (in Japanese) .

0410B002

N.Mikami: Effect of Cardiac Support Device Size on Right and Left Ventricular Function: Earlier impairment of
diastolic function of the right ventricle than of the left ventricle, J. Kanazawa. Med. Univ., 37:9-19, 2012 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0410I001

M.Okada: Clinical cases of left-side inferior vena cava in patients for thoracoabdominal aortic aneurysm, 7th
Meeting of the German-Japanese Society for Vascular Surgery, (Awaji, '12.09).
－ 60 －

0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Professor

USUDA Katsuo

Assistant Professor

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Facultythoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy

Publications
Originals－ 61 －

0415B001

M.Sagawa, M.Tanaka, T.Kobayashi, T.Sobue, K.Nishii, T.Nakayama, K.Usuda, H.Aikawa, Y.Machida, M.Ueno,
T.Sakuma: The feasibility of performing a randomized controlled trial to evaluate the efficacy of lung cancer
screening by thoracic CT in Japan, The Journal of the Japanese Society of CT Screening, 18:159-162, 2012.

0415B002

X.i.Zhao: Significance of diffusion-weighted magnetic resonance imaging in diagnosis of lung cancer: correlation of
apparent diffusion coefficient value with clinicopathological factors, J. Kanazawa. Med. Univ., 37:35-46, 2012.

0415B003(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

0415B004(K.Ichikado), H.Muranaka, Y.Gushima, T.Kotani, H.M.Nader, K.Fujimoto, T.Johkoh, N.Iwamoto, K.Kawamura,
J.Nagano, K.Fukuda, N.Hirata, T.Yoshinaga, H.Ichiyasu, S.Tsumura, H.Kohrogi, A.Kawaguchi, M.Yoshioka,
T.Sakuma, M.Suga: Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome
predict mortality and vantilator dependency: a prospective observational cohort study, BMJ Open, 2:e000545, 111, 2012.

0415B005

Y.Machida, Y.Ueda, M.Ueno, M.Tanaka, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: The aquaporin family:A novel
player in the progression of adenocarcinoma of the lung, Proceedings of the Japanese Lung Cancer Society Lungcancer., 52:17-22, 2012 (in Japanese) .

0415B006

M.Sagawa, K.Nishii, T.Sobue, K.Eguchi, T.Nakayama, M.Sato, T.Kobayashi, H.Tanaka, S.Takahashi, T.Hayashi,
T.Suzuki, T.Sato, C.Hamashima, H.Saito, K.Ichikawa, K.Oketani, M.Hosoi, K.Sato, R.Kakinuma, J.Miura,
M.Tanaka, C.Endo, A.Sakurada, T.Kondo, T.Kanno, T.Hiura, A.Yokoyama, Y.Kurita, T.Sakuma, Y.Kibe,
K.Nishida, S.Mizukami, K.Ikeda, T.Matsunaga, K.Miyazaki, M.Sanada, K.Usuda, Y.Machida, M.Ueno, N.Motono,
T.Numata, T.Shibayama, S.Nakata, H.Nakayama, I.Kanetsuki, H.Kobayashi, J.Ohmori: Present and future of arandomized controlled trial in Japan evaluating the efficacy of lung cancer screening using low-dose thoracic CT,
The Journal of the Japanese Society of CT Screening, 19:196-203, 2012 (in Japanese) .

Reviews
0415C002

M.Sagawa, K.Usuda, N.Motono, M.Ueno, Y.Machida, M.Tanaka, T.Sakuma: Revised
recommendations(2010Edition) on lung cancer screening in "lung cancer clinical practice guidelines" of theJapanese lung cancer society, Proceedings of the Japanese Lung Cancer Society Lung cancer., 52:938-942, 2012
(in Japanese) .

0415C003

M.Sagawa, K.Usuda, M.Tanaka, Y.Machida, M.Ueno, N.Motono, T.Sakuma: The effcacy of lung cancer screening
with low-dose thoracic CT: The results of NLST and its interpretation, Japanese Association for Cancer Detection
and Diagnosis., 20:144-149, 2012 (in Japanese) .

Case Reports
0415D001

Y.Machida, M.Sagawa, M.Ueno, M.Tanaka, K.Usuda, T.Sakuma: A case of an extrapleural hematoma that caused
late-onset pleural effusion, The Journal of the Japanese Association for Chest Surgery., 26:56-59, 2012 (inJapanese) .

Others0415F001

M.Sagawa, T.Nakayama, M.Tanaka, T.Sakuma, T.Sobue: A randomized controlled trial the efficacy of thoracic CT
screening for lung cancer in Non-smokers of <30 pack-years aged 50-64 years(JECS study): research design, Jpn.
J. Clin. Oncol., 42:1219-1221, 2012.

Presentations at Conference
International Conference (Presentations)
0415I001

Y.Machida, Y.Ueda, M.Shimazaki, M.Sagawa, T.Sakuma: Global histone H3 lysine4(H3K4) dimethylation is an
important prognostic factor in lung cancer, ERS VIENNA 2012, (Austria, '12.09).
－ 62 －

0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Publications
Originals
0420B001

M.Noguchi, M.Noguchi, Y.Nakano, Y.Ono, T.Kosaka: Axillary reverse mapping using a fluorescence imaging
system in breast cancer, J. Surg. Oncol., 105:229-234, 2012.

0420B002

K.Miyazawa, Y.Takahashi, N.Morita, M.Moriyama, T.Kosaka, M.Nishio, T.Yoshimoto, K.Suzuki: Cyclooxygenase 2
and prostaglandin E2 regulate the attachment of calcium oxalate crystals to renal epithelial cells, Int. J. Urol.,
19:936-943, 2012.

0420B003

M.Noguchi, A.Motoyoshi, M.Earashi, H.Fujii: Long-term outcome of breast cancer patients treated withradiofrequency ablation, Eur. J. Surg. Oncol., 38:1036-1042, 2012.

－ 63 －

0420B004

T.Onishi, T.Kosaka, E.Morioka, D.Kaida, Y.Tomita, Y.Ono, M.Noguchi, H.Funaki, S.Kinami, K.Omote, Y.Nakano,N.Ueda: Low preoperative total cholesterol level predicts poor survival following curative resection in gastriccancer, J. Kanazawa. Med. Univ., 37:127-131, 2012.

Reviews
0420C001

M.Noguchi, Y.Nakano, M.Noguchi, Y.Ono, T.Kosaka: Local therapy and survival in breast cancer with distantmetastases, J. Surg. Oncol., 105:104-110, 2012.

Case Reports
0420D001

N.Ueda, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, S.Kinami, K.Omote,Y.Nakano, T.Kosaka, S.Nakata, H.Minato, H.Takamura: A case of drug resistant recurrent gastrointestinal stromal
tumor treated surgically by resection, partial hepatectomy and diaphragmectomy, Cancer & chemotherapy,
39:2438-2440, 2012 (in Japanese) .

0420D002

T.Ohnishi, S.Kinami, E.Morioka, D.Kaida, Y.Ohno, Y.Tomita, M.Noguchi, H.Funaki, K.Omote, Y.Nakano,N.Ueda, T.Kosaka: A case of gastric endocrine cell carcinoma that responded to chemotherapy with CPT11+CDDP, Cancer & chemotherapy, 39:2384-2386, 2012 (in Japanese) .

0420D003

E.Morioka, Y.Ohno, M.Noguchi, Y.Nakano, M.Noguchi, T.Kosaka, T.Takanaka: Recurrent breast cancer obtained
long-term survival with local treatment (surgery and stereotactic body radiotherapy) and systematic therapy,
Cancer & chemotherapy, 39:1942-1944, 2012 (in Japanese) .

0420D004

Y.Tomita, E.Morioka, D.Kaida, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, S.Kinami, K.Omote, Y.Nakano,N.Ueda, M.Noguchi, T.Kosaka: A case of port site recurrence after thoracoscopic resection for lung metastasis ofcecal cancer, Cancer & chemotherapy, 39:1923-1925, 2012 (in Japanese) .

Others
0420F001

M.Noguchi: Is axillary dissection unnecessary in patients with a positive sentinel lymph node?, Breast Cancer.,
19:279-281, 2012.

Presentations at Conference
International Conference (Presentations)
0420I001

D.Kaida, S.Kinami, T.Onishi, Y.Ono, Y.Tomita, M.Noguchi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, T.Kosaka: A
case of the gastric tube cancer who was reconstructed using the free jejunal autograft after the local resection ofgastric tube., The International College of Surgeons THe 58th annual congress of Japan section, (Tokyo, '12.06)，
The International College of Surgeons THe 58th annual congress of Japan section Abstract Book, 44, 2012.

0420I002

S.Kinami, T.Kosaka, D.Kaida, T.Onishi, Y.Ono, Y.Tomita, M.Yokoi, K.Omote, N.Ueda, Y.Nakano, S.Fushida,
T.Fujimura, T.Ohta: The life prognosis of patients performed the function-preserving gastrectomy for gastriccancer., The International College of Surgeons THe 58th annual congress of Japan section, (Tokyo, '12.06)，The
International College of Surgeons THe 58th annual congress of Japan section Abstract Book, 48, 2012.

0420I003

T.Ito, H.Kitakata, S.Kinami, K.Kawaura, T.Kosaka: A clinical study of endoscopic full-thickness resection for
submucosal invasive gastric cancer without sentinel node metastasis., UEGW2012, (Amsterdam :The Netherlands,'12.10).

0420I004(M.Earashi), M.Noguchi, A.Motoyoshi, H.Komiya, H.Fujii: Long-term outcome of breast cancer patients treatedwith radiofrequency ablation, San Antonio Breast Cancer Symposium, (San Antonio, '12.12)，Cancer Research,
72:410s, 2012.

0420I005

Y.Nakano, Y.Ohno, M.Noguchi, M.Noguchi, T.Kosaka: A false nagative for metastatic axillary lymph nodes in
PET-CT of a breast cancer patient, 22nd World Congress of International Association of Surgeons,
Gastroenterologists and Oncologists, (Bangkok, '12.12).
－ 64 －

0420I006

M.Noguchi, M.Noguchi, Y.Nakano, E.Morioka, Y.Ohno, T.Kosaka: Axillary reverse mapping during sentinel lymph
node biopsy in breast cancer, 22nd World Congress of International Association of Surgeons, Gastroenterologists
and Oncologists, (Bangkok, '12.12).

－ 65 －

0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Professor

KAWAHARA Norio

Spinal surgery

Professor(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

Associate Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

MAEOKA Hayato

TraumaSenior Assistant Professor

OKUDA Tetsuhito

Spinal surgery

Senior Assistant Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Assistant Professor

HATANO Eijyu

Spinal surgery

Assistant Professor

MIAKI Kohei

Hip surgery

Assistant Professor

HIROMURA Kentaro

TraumaAssistant Professor

YASUDA Yoshihito

Spinal surgery

Assistant Professor

FUKUI Kiyokazu

Hip surgery

Assistant Professor

KITAMURA Kenji

Hip surgery

Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

TOMIDOKORO Jun

Hip Surgery

Assistant Professor

MIKAMI Tomoaki

Hip surgery

Assistant Professor

NAKAGAWA Shintaro Hip surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Research Doctor

AKAGAWA Makoto

orthopaedic surgery

Research Doctor

ORITA Yugo

orthopaedic surgery

Research Doctor

TAKAHASHI Eiji

Hip surgery

Research Doctor

KANEKO Seiji

Hip surgery

Research Doctor

TAGUCHI Keita

orthopaedic surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, spinal cord injury

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral－ 66 －

prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal
cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4
is a digestive enzyme of CSPG . In future, we will clarify the mechanism.

Publications
Originals
0430B001

T.Matsumoto, A.Kaneuji, Y.Hiejima, H.Sugiyama, H.Akiyama, T.Atsumi, M.Ishii, K.Izumi, T.Ichiseki, H.Ito,
T.Okawa, K.Ohzono, H.Otsuka, S.Kishida, S.Kobayashi, T.Sawaguchi, N.Sugano, I.Nakajima, S.Nakamura,
Y.Hasegawa, K.Fukuda, G.Fujii, T.Mawatari, S.Mori, Y.Yasunaga, M.Yamaguchi: Japanese orthopaedic association
hip disease evaluation questionnaire (JHEQ): a patient-based evaluation tool for hip-joint disease. The
subcommittee on hip disease evaluation of the clinical outcome committee of the Japanese orthopaedic association,
J. Orthop. Sci., 17:25-38, 2012.

0430B002

T.Ichiseki, A.Kaneuji, Y.Ueda, S.Kaneko, S.Ueda, T.Matsumoto: The initial phase of oxidative stress in a steroidinduced osteonecrosis rabbit model, Adv Biosci Biotechnol, 3:978-982, 2012.

0430B006(H.Sasaki), K.Shintani, N.Takano, A.Kaneuji: A difference of acetabular stress distribution in various femoral
anteversion angle, Japanese Journal of Clinical Biomechanics., 33:211-214, 2012 (in Japanese) .

Case Reports
0430D001(S.Demura), N.Kawahara, H.Murakami, T.Akamaru, S.Kato, M.Oda, K.Tomita, H.Tsuchiya: Giant cell tumor
expanded into the thoracic cavity with spinal involvement, Orthopedics., 35:e453-e456, 2012.

0430D002(Y.Ueda), N.Kawahara, H.Murakami, S.Demura, H.Tsuchiya: Thoracic disk herniation with paraparesis treated withtransthoracic microdiskectomy in a 14-year-old girl, Orthopedics., 35:e774-e777, 2012.

0430D003(Y.Ueda), H.Murakami, S.Demura, N.Kawahara, K.Tomita, H.Tsuchiya: Eosinophilic granuloma of the lumbar spine
in an adult, Orthopedics., 35:e1818-e1821, 2012.

0430D004

K.Fukui: Strategy for a delayed infection of total hip arthroplasty using cementless inplants -The suppression of
infection with retaining of the well-fixed cementless stem-, Journal of the Japanese Society for Study of Bone andJoint Infections, 25:65-68, 2012 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

N.Kawahara: Total en bloc spondylectomy for spinal tumors with epidural extension, The 29th Spring Congress,
Korean Society of Spine Surgery, (Daejeon, '12.05).

0430G002

N.Kawahara: Total en bloc spondylectomy for tumors of the lower lumbar spine, The 29th Spring Congress, Korean
Society of Spine Surgery, (Daejeon, '12.05).

0430G003

N.Kawahara: Localized metastatic disease of the spine and unknown primary, AOSpine Asia Pacific Interactive
Courses, (Kuala Lumpur, '12.09).

0430G004

N.Kawahara: Metastatic disease of the spine at multiple sites in patient with known breast cancer and recent
neurological deterioration, AOSpine Asia Pacific Interactive Courses, (Kuala Lumpur, '12.09).

0430G005

N.Kawahara: Operative decision making in matastatic tumor of cranio-cervical junction, AOSpine Asia PacificInteractive Courses, (Kuala Lumpur, '12.09).

－ 67 －

0430G006

N.Kawahara: Different approach for the cranio-cervical tumor surgery, AOSpine Asia Pacific Interactive Courses,(Kuala Lumpur, '12.09).

0430G007

N.Kawahara: Treatment of the complications of cranio-cervical tumor surgery, AOSpine Asia Pacific Interactive
Courses, (Kuala Lumpur, '12.09).

0430G008

N.Kawahara: Complication management procedures, AOSpine advances video seminar in surgical techniques,(Seoul, '12.11).

International Conference (Synposium)
0430H001

N.Kawahara: Two cases of GCT with long term follow up, 2nd Bologna-Budapest Spine Meeting on Tumors &Osteoporosis, (Budapest, '12.09).

0430H002

N.Kawahara: Two operated cases of solitary RCC with long term follow up, 2nd Bologna-Budapest Spine Meetingon Tumors & Osteoporosis, (Budapest, '12.09).

International Conference (Presentations)
0430I001

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Mean ten-year wear comparison between conventionaland highly cross-linked polyethylene against a zirconia head, 2012 ICJR San Diego (in collaboration with
Orthopedics Today), (San Diego, '12.04).

0430I002

M.Muratani, A.Kobe, M.KIriyama, M.Kawahara, M.Ariiso, K.Ushiyama, C.Tsuji, K.Kagechika, A.Kaneuji: Early
recovery change of hip abductor,knee extensor and flexor strength after total hip arthroplasty, The 3rd AsiaOceanian Conference of Physical and Rehabilitation Medicine, (Bali, '12.05).

0430I003

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, S.Kaneko, T.Matsumoto: Joint preservation rate 18-22
years after rotational acetabular osteotomy for developmental hip dysplasia, European Hip Society 10th Congress,(Milano, '12.09).

0430I004

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Is there necessarily a correlation between the crossover
sign and osteoarthritis over a two decade period?, European Hip Society 10th Congress, (Milano, '12.09).

0430I005

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Neuroscience 2012 -Society for Neuroscience-, (New Orleans, '12.10).

0430I006

T.Sugimori, K.Kitamura, T.Ichiseki, K.Fukui, A.Kaneuji, T.Matsumoto: Improved accuracy of femoral componentalignment with the hip center marking technique compared with the conventional implantation in total knee
arthroplasty, Combined 33rd SICOT & 17th PAOA Orthopaedic World Conference, (Dubai, '12.11).

0430I007

K.Hiromura, H.Maeoka, K.Kitamura, M.Okada, T.Matsumoto: Treatment of athletic injuries of the posteriorsternoclavicular dislocation, Combined 33rd SICOT & 17th PAOA Orthopaedic World Conference, (Dubai, '12.11).

0430I008

K.Kitamura, T.Sugimori, A.Kaneuji, T.Ichiseki, K.Fukui, T.Matsumoto: Relationship between the femoral
component sizing and the postoperative knee flexion in posterior stabilized total knee arthroplasty, Combined 33rd
SICOT & 17th PAOA Orthopaedic World Conference, (Dubai, '12.11).

－ 68 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

SASAGAWA Yasuo

brain tumor

Assistant Professor

SIRAGA Syunsuke

general neurosurgery

Assistant Professor

TORIGOE Keiichiro

general neurosurgery

Assistant Professor

YAMAMOTO Jiro

general neurosurgery

Research Doctor

TSUKADA Tsuyoshi

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly－ 69 －

1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001

Y.Sasagawa, O.Tachibana, S.Shiraga, H.Takata, T.Akai, H.Iizuka: A clincal feature and therapeutic strategy in
pituitary adenomas associated with intracranial aneurysms, Neurological surgery., 40:15-21, 2012 (in Japanese) .

Reviews
0440C003

T.Akai, H.Iizuka, S.Kawakami: Classification and operation for non-syndromic craniosynostosis, Nervous system inchildren., 37:297-306, 2012 (in Japanese) .

0440C004

T.Akai, H.Iizuka, M.Yamashita, S.Kawakami, H.Satoh, Y.Saikawa: Craniosynostosis－Symptoms, diagnosis,
operation methods, and characteristics of patients treated at Kanazawa Medical University－, J. Kanazawa. Med.
Univ., 37:162-169, 2012 (in Japanese) .

Case Reports
0440D001

Y.Sasagawa, O.Tachibana, S.Siraga, H.Takata, E.Kinoshita, T.Nojima, H.Iizuka: Secondary malignant giant celltumor of the clivus: Case report, Clin. Neurol. Neurosurg., 114:786-788, 2012.

0440D002

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, K.Torigoe, T.Iida, E.Kinoshita:
Brain metastasis from testicular cancer : a case report, Japanese Journal of Urological Surgery, 25:1239-1242,
2012 (in Japanese) .

0440D003

K.Torigoe, T.Akai, T.Iida, S.Shiraga, Y.Sasagawa, O.Tachibana, H.Iizuka: Hemangiopericytoma on the intradural
thoracic spinal cord: a case report, Neurological surgery., 40:351-357, 2012 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0440G001

O.Tachibana, Y.Sasagawa, H.Iizuka: Slurgical significance of anatomy for supra-sellar tumor in relation toarachnoid membrane and critical perforating branches on extended transsphenoidal surgery, The 5th international
neurosurgical conference harbin, (China, '12.07).

International Conference (Presentations)
0440I001

O.Tachibana, Y.Sasagawa, K.Torigoe, K.Okamoto, T.Akai, H.Iizuka: Clinical significance of perforating branches
on extended transsphenoidal surgery, AANS, (Florida, '12.04).

0440I002

T.Iida, K.Torigoe, T.Akai, H.Iizuka, J.Yamamoto, S.Sato: Transarticular screw fixation in subaxial cervical spine,
AANS, (Florida, '12.04).

0440I003

Y.Sasagawa, O.Tachibana, S.Siraga, H.Takata, T.Akai, H.Iizuka: A clinical feature and therapeutic strategy of
pituitary adenomas associated with intracranial aneurysms, AANS, (Florida, '12.04).

0440I004

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: The chronological changes in surgical method
and comparison of treatment costs and hospitallzation periods between conventional and dustraction osteogenesis
for non-syndromic craniosynostosis, The 40th annual meeting of the international society for pediatricneurosurgery, (Australia, '12.09).

－ 70 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

MORITA Reiji

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

NISHIO Akiko

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

TAGUCHI Hisao

Plastic and Reconstructive Surgery

Assistant Professor

DOI Yujin

Plastic and Reconstructive Surgery

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

SETO Ayano

Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Plastic and Reconstructive Surgery

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.
－ 71 －

Publications
Originals
0450B001

M.Kishibe, A.Nishio, R.Morita, S.Kawakami: Aggressive remodelling with pedicled skin flaps of the volar surface forthe release of contractures of the fingers, J. Plast. Surg. Hand Surg., 46:272-275, 2012.

0450B002

A.Komuro: bFGF promotes regeneration of costal cartilage from the preserved perichondrium of rabbit, J.
Kanazawa. Med. Univ., 37:47-57, 2012 (in Japanese) .

0450B003

A.Nishio, M.Yamashita, R.Taguchi, K.Shimada: Linear fractures of the pediatric orbit, The Japanese journal ofplastic & reconstructive surgery., 55:1337-1343, 2012 (in Japanese) .

Reviews
0450C005

T.Akai, H.Iizuka, S.Kawakami: Classification and operation for non-syndromic craniosynostosis, Nervous system inchildren., 37:297-306, 2012 (in Japanese) .

0450C006

T.Akai, H.Iizuka, M.Yamashita, S.Kawakami, H.Satoh, Y.Saikawa: Craniosynostosis－Symptoms, diagnosis,
operation methods, and characteristics of patients treated at Kanazawa Medical University－, J. Kanazawa. Med.
Univ., 37:162-169, 2012 (in Japanese) .

Short Communications
0450E001

R.Morita, K.Shimada, S.Kawakami: Low-grade central osteosarcoma of the orbit, J. Craniofac. Surg., 23:e178e180, 2012.

Presentations at Conference
International Conference (Presentations)
0450I001

A.Nishio, Y.Himi, M.Kishibe, K.Shimada, S.Kawakami: Three burn cases involving lower extremities complicated bydeep vein thrombosis.(Poster), 11th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Awajishima,'12.05).

0450I002

Y.Himi, M.Yagishita, S.Kawakami: In Vivo Regeneration of Cultured Cartilage Tissue Using Chitosan Nanofibers,
11th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Awajishima, '12.05).

0450I003

M.Yamashita, S.Kawakami, A.Nishio: Aesthetic and Functional Rhinoplasty: Correction of the Nasal Mid-Third,
11th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Awajishima, '12.05).

0450I004

A.Komuro, N.Koizumi, M.Yagishita, Y.Ueda, M.Shimasaki, S.Kawakami: Cartilage-progenitor cells in the
perichondrium and the acceleration of their early proliferation by bFGF in the perichondrium-preserved harvest of
rabbit costal cartilage, 11th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Awajishima, '12.05).

0450I005

K.Shimada, S.Kawakami: ITreatment of the severely injured hand, 11th Japan-Korea Congress of Plastic andReconstructive Surgery, (Awajishima, '12.05).

0450I006

Y.Nishibu, J.Miyake, R.Morita, K.Shimada, S.Kawakami: Treatment for multiple pressure ulcers in a patient withparaplegia, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

0450I007

M.Yagishita, M.Shimasaki, Y.Ueda, S.Kawakami: Dual functions of aquaporin 1 in the regeneration of auricularelastic cartilage of rabbit, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

0450I008

Y.Himi, M.Yagishita, S.Kawakami: In Vivo Regeneration of Cultured Cartilage Tissue Using Chitosan Nanofibers,
4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

－ 72 －

0450I009

T.Miyanaga, Y.Haseda, T.Minamizawa: Perifascial areolar tissue graft for skin ulcer exposed tendon or bone, 4thCongress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

0450I010

A.Komuro, N.Koizumi, Y.Himi, M.Yagishita, Y.Ueda, M.Shimasaki, S.Kawakami: Cartilage-progenitor cells in the
perichondrium and the acceleration of their early proliferation by bFGF in the perichondrium-preserved harvest of
rabbit costal cartilage, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

0450I011

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: The chronological changes in surgical method
and comparison of treatment costs and hospitallzation periods between conventional and dustraction osteogenesis
for non-syndromic craniosynostosis, The 40th annual meeting of the international society for pediatricneurosurgery, (Australia, '12.09).

0450I012

K.Shimada, H.Sakurai, S.Ichioka, K.Watanabe, N.Ohara, H.Ohjimi, H.Nakazawa, S.Kawakami, K.Harii: Assessmentof the Convenience and Operability of A Portable NPWT Devise (Renasys GO) in Japan Using Foam and Cotton
Fillers, 4th Congress of the World Union of Wound Healing Societies, (Yokohama, '12.09).

－ 73 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Assistant Professor

OSHIKIRI Takahiro

Pediatric surgery

Assistant Professor

YASUI Yoshitomo

Pediatric surgery

Assistant Professor

TAKAHASHI
Sadayoshi

Pediatric surgery

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Faculty

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

－ 74 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication

Professor

KITAGAWA Kazuko

Professor(Additional Post)

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

cataract, thyroid ocular

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

YAGUCHI Hiromoto

corneal epithelium, glsucoma

Assistant Professor

HAGIWARA Kenta

ocular infection

Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology

Assistant Professor

OSADA Hiromi

cataract, ophthalmology

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology

Assistant Professoｒ

HATSUSAKA Natsuko ophthalmological optics

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Assistant Professor

TAKAHASHI Yorikocataract

ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 75 －

Publications
Originals
0470B001

M.Fukuda, H.Sasaki: Quantitative evaluation of corneal epithelial injury caused by n-heptanol using a corneal
resistance measuring device in vivo, Clin. Ophthalmol., 6:585-593, 2012.

0470B002

N.Mita, N.Hatsusaka, E.Shibuya, H.Osada, N.Shibata, S.Shibata, K.Sasaki, H.Sasaki: Change in retinal image
contrast with age in eyes with transparent lenses, J. Cataract Refract. Surg., 38:1783-1787, 2012.

0470B003(S.C.Shiboski), C.H.Shiboski, L.Criswell, A.Baer, S.Challacombe, H.Lanfranchi, M.Schiødt, H.Umehara, F.Vivino,
Y.Zhao, Y.Dong, D.Greenspan, A.M.Heidenreich, P.Helin, B.Kirkham, K.Kitagawa, G.Larkin, M.Li, T.Lietman,
J.Lindegaard, N.McNamara, K.Sack, P.Shirlaw, S.Sugai, C.Vollenweider, J.Whitcher, A.Wu, S.Zhang, W.Zhang,
J.Greenspan, T.Daniels: American college of rheumatology classification criteria for Sjögren's syndrome: a datadriven, expert consensus approach in the Sjögren's international collaborative clinical alliance cohort, ARTHRITCARE RES, 64:475-487, 2012.

0470B004

K.Hagiwara, K.Kitagawa, H.Sasaki: Two cases of varicella keratitis requiting long-term treatment for cure, Journalof the eye., 29:549-553, 2012 (in Japanese) .

Presentations at Conference
0470I001

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, E.Kubo, Y.Sakamoto, K.Sasaki, D.Beebe, F.Bai, Y.B.Shui: Anatomic
risk factors for age-related cataract in a rural japanese population, International Conference on The Lens, (Hawaii,'12.01).

0470I002

E.Kubo, N.Hasanova, H.Sasaki, N.Fatma, D.P.Singh: Sulforaphanc mobilizes cellular antioxidant defenses that
protect lens epithelial cells against damage by UV radiation, International Conference on The Lens, (Hawaii,'12.01).

0470I003(N.Fujii), K.Kawaguchi, H.Sasaki, N.Fujii: Simultaneous isomerization at the asp-4 residue in βB2-crystallin fromthe ager human eye lenses, International Conference on The Lens, (Hawaii, '12.01).

0470I004

M.Kojima, K.Sasaki, H.Sasaki: Pathogenic mechanism of heat cataract induced by infrared rays and electric wave
exposure, International Conference on The Lens, (Hawaii, '12.01).

0470I005

N.Hatsusaka, E.Shibuya, N.Mita, H.Osada, N.Shibata, S.Shibata, N.Fujita, H.Yaguchi, E.Kubo, K.Sasaki,
H.Sasaki: Influence of watr clefts and cofts and cortical cataract on refraction in human eye, International
Conference on The Lens, (Hawaii, '12.01).

0470I006

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, E.Kubo, H.Sasaki, H.Yonekura: Ultraviolet Binduced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, International
Conference on The Lens, (Hawaii, '12.01).

0470I007

M.Kojima, N.Hasanova, Y.Suzuki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Ocular Temperature Measurement duringg 40GHz Exposure to Rabbit, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

0470I008(Y.Susuki), A.Koike, M.Kojima, K.Sasaki, K.Wake, N.Hasanova, M.Taki, S.Watanabe, K.Sasaki, H.Sasaki:
Computational and experimental dosimetry for rabbit eyes exposed to millimeter waves, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

0470I009(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, H.Osada, E.Kubo, H.Sasaki, K.Sasaki: Factors influencing retinal image
contrast in eyes with retrodots (Reykjavik Eye Study), The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

0470I010

H.Osada, S.Shibata, R.Honda, N.Hatsusaka, M.Takahashi, M.Sasaki, Y.Hirata, N.Shibata, E.Kubo, H.Sasaki:
Pinguicula in urban office workers in Japan, The Association for Research in Vislon and Ophthalmology, (Florida,'12.05).

－ 76 －

0470I011

M.Fukuda, S.Shibata, N.Shibata, H.Osada, K.Hagiwara, H.Yaguchi, E.Kubo, H.Sasaki: Influence of antiglaucoma
fixed combination drugs to the cornea and aqueous humor concentration of timjolol maleate in rabbits, The
Association for Research in Vislon and Ophthalmology, (Florida, '12.05).

0470I012

M.Kojima, H.Sasaki, K.Sasaki, N.Hasanova, Y.Suzuki, M.Taki, K.Sasaki, K.Waki, S.Watanabe: Study of acuteocular damage threshold of 40 GHz millimeter wave, The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

0470I013

H.Sasaki, N.Hatsusaka, E.Shibuya, N.Mita, A.Okamoto, H.Osada, M.Kojima, E.Kubo, K.Sasaki: 12-year change ofcrystalline lens power by opacity type Reykjavik Eye Study, The Association for Research in Vislon andOphthalmology, (Florida, '12.05).

0470I014

N.Hatsusaka, Y.Suzuya, T.Kawahara, H.Sasaki: Relationship between reading performance of the elderly and eye
movemants, The Association for Research in Vislon and Ophthalmology, (Floroda, '12.05).

0470I015

E.Kubo, N.Hasanova, H.Sasaki, B.Chhunchha, N.Fatma, D.P.Singh: Sulforaphane mobilizes cellular antioxidant
defenses that protect lens epithelial cells against damage by UV radiation and delays rat cataract, The Association
for Research in Vislon and Ophthalmology, (Florida, '12.05).

0470I016(S.J.Bhosai), B.D.Gaynor, A.M.Heidenreich, E.K.Akpek, K.Kitagawa, G.Larkin, T.Porco, T.M.Lietman, SICCA
study Group: Evaluation of dry eye diagnostic tests of the cornea and conjunctiva for predicting sjogren's
syndrome from the international sjogrens syndrome registry, The Association for Research in Vislon andOphthalmology, (Florida, '12.05).

0470I017

E.Kubo, N.Hasanova, H.Sasaki, N.Fatma, D.P.Singh: Peroxoredpxon 6 and its induction by sulforaphane
upregulates cellular antioxidant defense signaling and prevention of cataract in rat lens, XX Biennial Meeting of theinternational society for eye research, (Berlin, '12.07).

0470I018

H.Sasaki, N.Hatsusaka, E.Shibuya, H.Osada, E.Kubo, K.Sasaki, F.Jonasson: Types of caratact and change ofcrystalline lens power and refractive power -reykjavik Eye Study-, XXX Congress of the ESCRS, (Milano, Italy,'12.09).

0470I019

M.Kojima, N.Hasanova, Y.Suauki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Investigation of ocular temperature change in rabbits during 40 HGz band exposure, EMC EUROPE
2012, (Rome, '12.09).

0470I020

M.Kojima, N.Hasanova, Y.Suauki, K.Wake, K.Sasaki, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: In vestigation of acute ocular damagc threshold of 40 GHz millimeter wave on rabbit, 37th IRMMW-THz
2012, (Korea, '12.09).

0470I021(T.Okuno), M.Kojima, N.Hasanova, Y.Ishiba, Y.Suzuki, D.HSliney: Injury thresholds for IR-A laser exposure in the
rabbit lens, Asian pacific association of laser medicine & surgery, (Taiwan, '12.11).

－ 77 －

0480

Department of Otorhinolaryngology-Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

YAMADA Kanako

Rhinology, generel otology

Assistant Professor

YAMAMOTO Junpei

Rhinology, Olfactory disorders, Upper respiratory disease

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology

Research Doctor

SAKAI Aya

Sleep apnea syndrome

Keywords of Researcholfactory disorders, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, headand neck tumor surgery, thyroid tumor surgery, skull base surgery, sleep apnea & snoar surgery

Outline of Research
Basic and clinical research for the diagnosis and treatment of olfactory disorders
Central mechanism of auduological function by MEG
Clinical research for head and neck tumor and oncology
Research for thyroid and parathyroid gland
Clinical reserach for snoar and sleep apnea

Publications
Originals
0480B001(M.Ito), Y.Maruyama, S.Murono, N.Wakisaka, S.Kondo, M.Hatano, S.Nakanishi, T.Miwa, T.Yoshizaki: Efficacy andsafety of garenoxacin in the treatment of upper respiratory tract infections, Auris Nasus Larynx, 39:512-518,
2012.

0480B003(M.Kobayashi), T.Miwa, Y.Kurose, K.Nibu, S.Matsune, J.Uchida, K.Tsuzuki, K.Kondo, H.Shiga, H.Fujino,
Y.Matsuwaki, H.Honma, S.Nakanishi, H.Mimura, T.Ogawa, T.Shimizu, H.Takebayashi, T.Aiba, H.Shojaku:
Multicenter Study of Modified Intravenous Olfactometry, Jpn. J. Rhinol., 51:445-449, 2012 (in Japanese) .

0480B004

A.Sakai, H.Mukoyama, A.Horiguchi, H.Shiga, T.Miwa: A case of Kawasaki disease with suspected peritionsillitis
and acute suppurative cervical lymphadenitis, Stomato-pharyngology / Japan Society of Stomato-pharyngology.,
25:73-78, 2012 (in Japanese) .

Reviews
0480C004

H.Shiga, J.Yamamoto, T.Miwa: Olefactory nerve transport of macromolecular drugs to the brain -A problem inolfactory impaired patients-, Oto-rhino-laryngology Tokyo., 55:15-19, 2012 (in Japanese) .
－ 78 －

0480C006

T.Miwa, K.Yamada, J.Yamamoto, Y.Kinoshita, H.Shiga: Middle turbinate fenestration method: An advanced
procedure of endoscopic sinus surgery for the patients with olfactory disorders due to chronic sinusitis, Oto-rhinolaryngology Tokyo., 55:376-379, 2012 (in Japanese) .

0480C010

H.Shiga, J.Yamamoto, T.Miwa: Clinical diagnosis of the olfactory nerve transport function, J. Pharm. Soc. Japan,
132:1263-1266, 2012 (in Japanese) .

Case Reports
0480D001

Y.Kinoshita, S.Inagaki, J.Yamamoto, A.Sakai, K.Yamada, Y.Shimode, H.Shiga, H.Tsuji, Y.Suzuka, T.Miwa: A
surgical treatment of deep neck infections surrounding hyoid bone, Journal of Japan Society for Infectious Diseases
in Otolaryngology., 30:81-84, 2012 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0480G001

T.Miwa: Practical aspects of olfactory disorders:Diagnosis, Tesing and Treatment, 15th ASIAN RESEARCHSYMPOSIUM IN RHINOLOGY, (Republic of Singapore, '12.05).

International Conference (Synposium)
0480H001

T.Miwa, H.Shiga, J.Yamamoto, RM Costanzo: Quality of Life in Patients with Loss of Smell and Taste, ,XVIInternational Symposium on Olfaction and Taste, (Stockholm, '12.06).

International Conference (Presentations)
0480I001

J.Yamamoto: Effect of kamikihito (TJ-137) on paclitaxel induced olfactory neuropathy in vivo., the 14t JapanKorea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery, (Kyoto, '12.04).

0480I002

H.Shiga, J.Taki, S.Kinuya, J.Yamamoto, N.Watanabe, H.Tonami, K.Washiyama, R.Amano, M.Furukawa, T.Miwa:
Reduced olfactory nerve connectivity and olfactory bulb volume in patients with olfactory disorders., The 15th
International Symposium on Olfaction and Taste, (Stockholm, Sweden, '12.06).

0480I003

Y.Suzuka, M. Higuchi, D. Ohyama, J. Kawai: Objective judgement of the noticed sound in mixed sounds using a
coherence function between brain signal and sound envelope, １８th International Conference on Biomagnetism,(Paris France, '12.08)，proceeding, 2012.

－ 79 －

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

TAKEDA Kiminobu

Medical mycology

Assistant Professor

HASEI Maki

Skin tumor and growth factores, Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Assistant Professor

SAKAMOTO Tomoko Medical mycology

Research Doctor

HATTA Jyunko

Image analysis

Research Doctor

NANBU Masayuki

Dermatopathology

Research Doctor

KOJIMA Kiyoto

genetic diagnosis

Research Doctor

KITAYAMA Asuka

cutaneous malignant tumor

Research Doctor

MURAMOTO Mutsuko Immunology

Research Doctor

WAKASA Asako

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, langerhans cell

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

－ 80 －

Publications
Originals
0490B001

K.Takeda, A.Nishibu, K.Anzawa, T.Mochizuki: Molecular epidemiology of a major subgroup of Arthroderma
benhamiae isolated in Japan by restriction ｆragment ｌength polymorphism analysis of the non-transcribed spacer
region of ribosomal RNA gene, Jpn.J.Infect.Dis., 65:233-239, 2012.

0490B002

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki: New strain typing method with Sporothrix schenckii using
mitochondrial DNA and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)
technique, J. Dermatol., 39:362-365, 2012.

0490B003(R.Kano), M.Kawasaki, T.Mochizuki, M.Hiruma, A.Hasegawa: Mating genes of the Trichophyton mentagrophytes
complex, Mycopathologia, 173:103-112, 2012.

0490B004(T.Nakamura), A.Nishibu, M.Yasoshima, C.Tanoue, N.Yoshida, J.Hatta, T. Miyamoto, M.Nishii, T.Yanagibashi,
Y.Nagai, K.Takatsu, T.Mochizuki, K.Ogawa: Analysis of Trichophyton antigen-induced contact hypersensitivity inmouse, J. Dermatol. Sci., 66:144-153, 2012.

0490B005(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Himura: Epidemiological aspects of Trichophyton

rubrum var. raubitschekii in Japan, J. Dermatol., 39:1000-1001, 2012.
0490B006

T.Sakamoto, K.Anzawa, T.Fujii, H.Tanabe, T.Mochizuki, T.Toyomoto: An outbreak of Trichophyton tonsurans
infection and its surveillance in a women's university judo team, Skin research, 11:313-318, 2012 (in Japanese) .

Case Reports
0490D001

T.Mochizuki, H.Kobayashi, K.Takeda, K.Anzawa, H.Ishizaki: The first human cases of Americano-European raceof Arthroderma benhamiae infection in Japan, Jpn. J. Infect. Dis., 65:558-559, 2012.

0490D002(K.Tamura), T.Matsuyama, E.Yahagi, T.Kojima, E.Akasaka, A.Kondo, N.Ikoma, T.Mabuchi, S.Tamiya, A.Ozawa,T.Mochizuki: A case of chromomycosis treated by surgical therapy combined with preceded oral administration of
terbinafine to reduce the size of the lesion, Tokai J. Exp. Clin. Med., 37:6-10, 2012.

0490D003

T.Mochizuki, M.Kawasaki, K.Anzawa, K.Kojima, J.Hatta, H.Tanabe, S.Higaki, S.Fujita: Extra-scalp black dot
ringworm caused by Trichophyton tonsurans among contact sports players, Mycopathologia, 173:241-244, 2012.

0490D004

A.Nishibu, E.Sakai, N.Oyama, T.Yamamoto: Endothelin receptor antagonist bosentan improves the dermalsclerosis in a patient with systemic sclerosis, Aust. J. Dermatol., 53:32-33, 2012.

Others
0490F001(M.Tochigi), T.Ochiai, C.Mekata, H.Nishiyama, K.Anzawa, M.Kawasaki: Sporotrichosis of the face by
autoinoculation in a patient undergoing tacrolimus treatment, J. Dermatol., 39:796-798, 2012.

Presentations at Conference
International Conference (Synposium)
0490H001

T.Mochizuki: Outbreaks of community-acquired and nosocomial dermatophytoses in Japan, The 18th Congress ofInternational Society of Medical and Veterinary Mycology, (Berlin, Germany, '12.06).

International Conference (Presentations)
0490I001

K.Kojima, K.Niida, A.Nishibu, T.Mochizuki: A case of hereditary angioedema type 1 with blisters, The 2nd
Eastern Asia Dermatology Congress, (Beijin, '12.06).

0490I002

M.Kawasaki, K.Anzawa, T.Mochizuki: Is Trichophyton interdigitale a valid species?, The 18th Congress ofInternational Society of Medical and Veterinary Mycology, (Berlin, Germany, '12.06).
－ 81 －

0500

Department of Urology

Faculty
Title

Name

Field of Specialization

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Associate Professor

MORIYAMA Manabu

kidney transplantation, kidney stone disease

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

ISHII Takeo

general urology

Assistant Professor

NAKAI Dan

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001

K.Miyazawa, M.Matoba, H.Minato, N.Morita, I.Chikazawa, K.Ota, K.Tokunaga, H.Tonami, T.Nojima, K.Suzuki:
Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its
incidence and risk factors, Jpn. J. Radiol., 30:635-641, 2012.

0500B002

K.Miyazawa, Y.Takahashi, N.Morita, M.Moriyama, T.Kosaka, M.Nishio, T.Yoshimoto, K.Suzuki: Cyclooxygenase 2
and prostaglandin E2 regulate the attachment of calcium oxalate crystals to renal epithelial cells, Int. J. Urol.,
19:936-943, 2012.

0500B003

S.Maeda, K.Tsukasaki, T.Kanda, T.Shimasaki, M.Moriyama, Y.Kohno, K.Kyuji: Supply of goods from hospitals to
outpatients practicing intermittent self-catheterization in Japan, Int J of Urol Nurs, 6:115-124, 2012.

Reviews－ 82 －

0500C001

M.Moriyama, K.Miyazawa, K.Suzuki: Stone matrix components and analysis methods thereof, Journal of Medical
Technology, 56:285-290, 2012 (in Japanese) .

0500C004

K.Miyazawa, N.Morita, K.Suga, M.Moriyama, K.Suzuki: Outlook for recurrence prevention from the viewpoint of
the guidelines on urolithiasis, Acta Urol. Jpn., 58:707-711, 2012 (in Japanese) .

Case Reports
0500D002

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, K.Torigoe, T.Iida, E.Kinoshita:
Brain metastasis from testicular cancer : a case report, Japanese Journal of Urological Surgery, 25:1239-1242,
2012 (in Japanese) .

0500D003

I.Chikazawa, D.Nakai, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Minato, H.Tachibana,A.Kiyuyama: A case of renal cell carcinoma with cystic necrosis, J. Kanazawa. Med. Univ., 37:66-69, 2012 (inJapanese) .

0500D004

I.Chikazawa, T.Tanaka, K.Suzuki, E.Kinoshita: A case of Mixed epithelial and stromal tumor of the kidney,
Japanese Journal of Urological Surgery, 25:1883-1886, 2012 (in Japanese) .

0500D005

I.Chikazawa, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, T.Nojima: A case of adrenal hemorrhage due toadministration of anticoagulant, Japanese Journal of Clinical Urology, 66:965-968, 2012 (in Japanese) .

Others
0500F001(K.Kouri), K.Suzuki: Guidelines on urolithiasis: an outline and effective use of the revised version, Acta Urol. Jpn.,
58：695-696, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0500I001

Katsuhito Miyazawa, Dan Nakai, Manabu Moriyama, Koji Suzuki: Expressions and functions of protease-activatedreceptors in renal tubular epithelial cells, 12th International Symposium on Urolithiasis, (Ouro Preto(Brazil),'12.05).

0500I002

Moriyama M.T., Nakai D., Morita N., Ishii T., Tachibana H., Chikazawa I., Suga K., Miyazawa K., Tanaka T.,
Suzuki K.: Unilateral urological double cancer after kidney transplantation, 24th International Congress of theTransplantation Society, (Berlin, '12.07).

0500I003

K.Miyazawa, D.Nakai, N.Morita, I.Chikazawa, K.Suga, M.Moriyama, T.Tanaka, K.Suzuki, M.Matoba, H.Minato:
Analysis of incidence and risk factor of seed migration after transperineal interstitial prostate brachytherapy with I125 free seeds, The 32nd Congress of the Societe Internationaled Urologie, (Fukuoka, '12.10).

－ 83 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Professor

MAKINODA Satoru

Associate Professor

Field of Specialization

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines
Gynecologic Pathology, Tumor Virology, Sexually Transmitted
SASAGAWA Toshiyuki
Infection Research, Immunology

Associate
Professor(Additional Post)

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine

Senior Assistant Professor

WASEDA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Senior Assistant Professor

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

YAMAGUCHI Naotaka perinatal medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 84 －

Publications
Originals
0510B001

T.Sasagawa, T.Mitsuishi: Novel polymerase chain reaction method for detecting cutaneous human papillomavirus
DNA, J. Med. Virol., 84:138-144, 2012.

0510B002

M.Rahman, T.Sasagawa, R.Fujii, H.Tomizawa, S.Makinoda: Intimate partner violence and unintended pregnancy
among Bangladeshi women, J. Interpers. Violence, 27:2999-3015, 2012.

0510B003(S.Kawaguchi), K.Shigehara, T.Sasagawa, M.Shimamura, T.Nakashima, K.Sugimoto, K.Nakashima, K.Furubayashi,
M.Namiki: Liquid-based urine cytology as a tool for detection of human papillomavirus, Mycoplasma spp., andUreaplasma spp. in men, J. Clin. Microbiol., 50:401-406, 2012.

0510B004

M.Rahman: Women's autonomy and unintended pregnancy among currently pregnant women in Bangladesh,
Matern. Child Health J., 16:1206-1214, 2012.

Reviews
0510C001

T.Sasagawa, H.Takagi, S.Makinoda: Immune responses against human papillomavirus(HPV) infection and evasion ofhost defense in cervical cancer, J. Infect. Chemother., 18:807-815, 2012.

Case Reports
0510D001(S.Kawaguchi), K.Shigehara, T.Sasagawa, M.Kuribayashi, A.Junicho, T.Hasegawa, Y.Maeda, M.Namiki: A casestudy of human papillomavirus-associated bladder carcinoma developing after urethral condyloma acuminatum, Jpn.
J. Clin. Oncol., 42:455-8, 2012.

Presentations at Conference
International Conference (Presentations)
0510I001

R.Fujii, T.Waseda, S.Fujita, N.Neyatani, H.Takagi, T.Sasagawa, S.Makinoda, T.Utsunomiya: Usefullness of G-CSF
for LUF caused by clomiphene-HCG treatment, The International Ovarian Conference 2012, (Tokyo, '12.03).

0510I002

R.Fujii, N.Neyatani, T.Waseda, S.Fujita, H.Takagi, T.Sasagawa, S.Makinoda, T.Utsunomiya: Granulocyte colonystimulating factor (G-CSF) prevents LUF in clomiphene treatment, 28th Annual Meeting of European Society of
Human Reproduction and Embryology(ESHRE), (Istanbul, '12.07).

0510I003

Y.Oka, M.Rahman, T.Waseda, S.Makinoda: Prenatal diagnosis of fetal respiratory function: evaluation of fetal lungmaturity using lung-to-liver signal intensity ratio at magnetic resonance, 22nd World Congress on Ultrasound in
Obstetrics and Gynecology, (Copenhagen, '12.09).

0510I004

T.Waseda, N.Neyatani, Y.Oka, R.Fujii, T.Sasagawa, S.Makinoda: Evaluation of the transcatheter arterial infusionof CDDP as neoadjuvant chemotherapy for cervical cancer by MRI and its prognosis, 22nd World Congress on
Ultrasound in Obstetrics and Gynecology, (Copenhagen, '12.09).

0510I005

S.Makinoda: An effective treatment against Luteinized Unruptured Follicle using Granulocyte colony-stimulating
factor (G-CSF), 20th FIGO World Congress of Gyencology and Obstetrocs, (Rome, '12.10).

0510I006

N.Neyatani, N. Yamaguchi, H. Takagi, R. Fujii, S.Makinoda: Clinical study on fertility in women following renaltransplantation, 20th FIGO World Congress of Gyencology and Obstetrocs, (Rome, '12.10).

0510I007

H.Takagi, S.Makinoda: Efficacy and safety of long-term dienogest therapy for endometriosis, 20th FIGO World
Congress of Gyencology and Obstetrocs, (Rome, '12.10).

0510I008

M.Rahman, S.Makinoda: Sought help for intimate partner violence(IPV) against women:Does it actually reflect
women's experience of IPV? A study of national Bangladeshi sample, 140th American Public Health Association
Annual Meeting, (San Francisco, '12.10).
－ 85 －

0510I009

T.Sasagawa: A multi-center stury(L-HERS) for prevalent HPV genotypes and abnormal cytology in young Japanesewomen, 28th International Papillomavirus Conference, (Puerto Rico, '12.12).

－ 86 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

SHIRAISHI Miharu

Clinical anesthesia, Pain medicine, Palliative medicine

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, ShockAssistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

NISHIIKE Satoshi

Clinical anesthesia, Nerve block, Vascular reactivity

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity

Assistant Professor

BEN Asami

Clinical anesthesia

Assistant Professor

HORIUCHI Katsura

Clinical anesthesia, Intensive care medicine

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

MURATA Yuriko

Clinical anesthesia

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

SAITO Takahiro

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Originals
0520B001

T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi: Characterization of proteinssecreted by pancreatic cancer cells with anticancer drug treatment in vitro, Oncol. Rep., 28:1968-1976, 2012.

0520B002

W.Zhang, T.Shibamoto, Y.Kuda, Y.Kurata, S.Shinomiya, H.Kida, H.Tsuchida: Vascular perfusion limits mesentericlymph flow during anaphylactic hypotension in rats, Am. J. Physiol. Regul. Integr. Comp. Physiol., 302:R1191R1196, 2012.

Reviews－ 87 －

0520C001

H.Tsuchida, H.Kida: Perioperative β-Adrenergic Blocking Agents and Postoperative Prognosis, The Japanesejournal of anesthesiology., 61:471-477, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0520I001

Y. Murata, Y. Tanaka, S. Nishiike, M. Ogawa, H. Tsuchida: Hemodynamic effects of phenylephrine on hypotension
during combined general and epidural anesthesia, 15th World Congress of Anesthesiologists, (Buenos Aires,'12.03).

0520I002

S. Nishiike, T. Hiramatsu, H. Tsuchida: Involvement of the high mobility group box-1 in vascular and systemic
responses to sepsis in the rat, 15th World Congress of Anesthesiologists, (Buenos Aires, '12.03).

－ 88 －

0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Professor

KAGECHIKA Kenji

Senior AssistantProfessor(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0540B001

Y.Noborisaka, M.Ishizaki, M.Nakata, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Cigarette smoking,proteinuria, and renal function in middle-aged Japanese men from an occupational population, Environ. HealthPrevent. Med., 17:147-156, 2012.

Presentations at Conference
International Conference (Key Note Lecture)
0540G001(F.Nogata), Y.Yokota, Y.Kawamura, K.Kagechika: Vizualization of Internal Microstructure of Heel Bone forInspecting Osteoporosis Using Ultrasound, The Asia-Pacific Interdisciplinary Research Conference, (Irago, '12.11).

International Conference (Presentations)
0540I001

K.Kagechika, M.Nakata, M.Tsubokawa, H.Kawasaki, M.Yamaguchi, S.Yura, A.Nakanami, Y.Takagi: Evaluation ofchange in dynamic property of vessel wall,dynamic deformability and strength of arteriosclerotic and ruptured bloodvessel by ultrasound, The 3rd Asia-Oceanian Conference of Physical and Rehabilitation Medicine, (Bali, '12.05).

0540I002(Y.Takagi), H.Yamada, Y.Kanazawa, H.Ebara, Y.Mikami, T.Yamamoto, K.Kagechika: Intrathecal baclofen therapy
for severe spasticity, The 3rd Asia-Oceanian Conference of Physical and Rehabilitation Medicine, (Bali, '12.05).

0540I003(S.Yura), Y.Takagi, K.Kagechika: The effectiveness of mouth-opening exercise in patients with chronic closed lockof the temporomandibular joint, The 3rd Asia-Oceanian Conference of Physical and Rehabilitation Medicine, (Bali,'12.05).
－ 89 －

0540I004

M.Muratani, A.Kobe, M.KIriyama, M.Kawahara, M.Ariiso, K.Ushiyama, C.Tsuji, K.Kagechika, A.Kaneuji: Early
recovery change of hip abductor,knee extensor and flexor strength after total hip arthroplasty, The 3rd AsiaOceanian Conference of Physical and Rehabilitation Medicine, (Bali, '12.05).

0540I005

K.Kagechika, M.Nakata, M.Tsubokawa, H.Kawasaki, S.Yura, Y.Takagi: Pain can be estimated by measurement byelectric phenomenon, The 22nd Japanese-Korean Combined Orthpaedic Symposium, (Nikko, '12.06).

0540I006

K.Kagechika, F.Nogata, M.Nakata, M.Tsubokawa, H.Kawasaki, A.Nakanami, Y.Takagi: Ultasonic evaluation ofchange in dynamic property of vessel wall,dynamic deformability and strength of arteriosclerotic and ruptured bloodvessel, Asia Pasific Stroke Conference 2012, (Tokyo, '12.09).

－ 90 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Associate Professor

OGURA Kenichi

Emergency, Neurosurgery

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

GOTO Tetsuro

Emergency

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

IWAI Junichi

Emergency

Research Doctor

WATANABE Atsushi

Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 91 －

0570

District medical

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Senior AssistantProfessor(Additional Post)

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi,
H.Toga: Sleep apnoea syndrome as a risk for mortality in elderly inpatients, J. Int. Med. Res., 40:601-611, 2012.

0570B002

S.Maeda, K.Tsukasaki, T.Kanda, T.Shimasaki, M.Moriyama, Y.Kohno, K.Kyuji: Supply of goods from hospitals to
outpatients practicing intermittent self-catheterization in Japan, Int J of Urol Nurs, 6:115-124, 2012.

－ 92 －

0575

Department of Gastroenterological Endoscopy

Faculty
Title

Name

Professor

ITO Tohru

Associate Professor

Senior Assistant Professor

Assistant Professor

Assistant Professor

Field of Specialization

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAWAURA Ken
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Presentations at Conference
International Conference (Synposium)
0575H001

T.Itoh: Endoscopy resection and submucosa dissection, The 14th Japan-Russia Endoscopy Symposium, (Moscow,'12.02).

0575H002

T.Itoh: Endoscopical diagnosis and ESD for early gastric cancer, Managements of Precancerous Conditions andLesions in the Stomach International Endoscopy Workshop, (Yaroslavl, '12.07).

International Conference (Presentations)
0575I001

T.Ito, H.Kitakata, S.Kinami, K.Kawaura, T.Kosaka: A clinical study of endoscopic full-thickness resection for
submucosal invasive gastric cancer without sentinel node metastasis., UEGW2012, (Amsterdam :The Netherlands,'12.10).

－ 93 －

0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

YOSHIMURA Hiroshi temporomandibular joint disorders, stomatology, neuroscience

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

Assistant Professor

TOMIYAMA Takashi

odontogenic infection

Assistant Professor

HONJO Miho

Orthodontics

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0580B001

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Multimodal cross-talk of olfactory and gustatory information in theendopiriform nucleus in rats, Chem. Senses, 37:681-688, 2012.

Presentations at Conference
International Conference (Presentations)
0580I001

N.Segami: Temporomandibular joint pathology and surgery, XXⅠCongress of the European Association for
Cranio-Maxillofacial Surgery, (Dubrovnik,Croatia, '12.09).

－ 94 －

S ch o o l o f N u r s i n g

8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing

Associate Professor

SAKAI Keiko

Communication Skills

Senior Assistant Professor

MATSUI Yuko

Fundamental Nursing

Assistant Professor

OKAYAMA Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireAssistant Professor

KYUJI Kazuyo

Nursing Students and Proffessional Sprit

Keywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

Publications
Originals
8010B001

S.Maeda, K.Tsukasaki, T.Kanda, T.Shimasaki, M.Moriyama, Y.Kohno, K.Kyuji: Supply of goods from hospitals to
outpatients practicing intermittent self-catheterization in Japan, Int J of Urol Nurs, 6:115-124, 2012.

8010B003

S.Maeda, T.Takiuti, T.Komatsu, Y.Kohno, K.Kyuji: Visiting nurse's experience of difficulty in performing catheter
management of long-term indwelling urinary catheter users, Journal of Japan Academy of Home Care., 16:68-75,
2012 (in Japanese) .

－ 95 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring

Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Nursing Ethics, Terminal Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001(J.Sugama), H.Sanada, Y.Shigeta, G.Nakagami, C.Konya: Efficacy of an improved absorbent pad on incontinenceassociated dermatitis in older women: cluster randomized controlled trial, BMC Geriatr., doi:10.1186/1471-231812-22, 2012.

8040B002(S.Iizaka), J.Matsuo, C.Konya, R.Sekine, J.Sugam, H.Sanada: Estimation of protein requirements according tonitrogen balance for older hospitalized adults with pressure ulcers according to wound severity in Japan, J. Am.
Geriatr. Soc., 60:2027-2034, 2012.

Short Communications
8040E001(Y.Kofuji), K.Nomura, C.Nakayama, M.Yamazaki: General duty male nurses experience providing care to female
patients, Journal of Japanese Society of Nursing Research., 35:63-69, 2012 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
8040H001

C.Konya: Management of damage to elderly skin caused by medical adhesive tape, The 4th Congress of the World
Union of Wound Healing Societies, (Yokohama, '12.09)，The 4th Congress of the World Union of Wound Healing
Societies, 209.

International Conference (Presentations)
8040I001

C.Konya, Y.Mizokami, R.Kamide, K.Tokunaga, G.Nakagami, H.Sanada: Reliability of ABCD-stoma, a scale that
evaluates the severity of peristomal skin disorders, The 4th Congress of the World Union of Wound Healing
Societies, (Yokohama, '12.09)，The 4th Congress of the World Union of Wound Healing Societies, 340.

－ 96 －

8050

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKAYAMA Naoko

community/elderly unrsing science

Senior Assistant Professor

KOIZUMI Yumi

community/elderly unrsing science

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8050B001

K.Ishigami, M.Okuro, Y.Koizumi, K.Satoh, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association ofsevere hypertension with pneumonia in elderly patients with acute ischemic stroke, Hypertens. Res., 35:648-653,
2012.

8050B002

K.Kitaoka, F.Ochiai, M.Uchida, T.Hashimoto, T.Terai: The effects of '1-2-3 Magic' British parenting support
program applied to Japanese families, Journal of Japanese Society of Nursing Research., 35:91-101, 2012 (inJapanese) .

8050B003

T.Hashimoto, N.Takayama: Education of care workers for elderly people： A comparative study of Germany andJapan, Studies in comparative culture, 104:311-321, 2012 (in Japanese) .

－ 97 －

8060

Pediatric Nursing

Faculty
Title

Name

Associate Professor

MIYAUCHI Tamaki

Assistant Professor

TERAI Takahiro

Field of Specialization
Caring for Children with Chronic illness, Family Nursing in Child ＆Maternal Health Care
Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention

Publications
Originals
8060B001

Tamaki Miyauchi: Families with Children with Developmental Disorders:Review of the Literature on Psychosocialand Social Problems, The Journal of child health., 71：282-288, 2012 (in Japanese) .

8060B002

K.Kitaoka, F.Ochiai, M.Uchida, T.Hashimoto, T.Terai: The effects of '1-2-3 Magic' British parenting support
program applied to Japanese families, Journal of Japanese Society of Nursing Research., 35:91-101, 2012 (inJapanese) .

－ 98 －

8070

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

OCHIAI Fumie

Maternity Health, Child Health, Midwifery

Associate Professor

SASANO Kyoko

Crinical nursing, Nursing education

Assistant Professor

TSUBOMOTO Takiko Maternity Nursing

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing

Assistant Professor

KITAHAMA Masami

Crinical Maternity Nursing

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8070B002

K.Kitaoka, F.Ochiai, M.Uchida, T.Hashimoto, T.Terai: The effects of '1-2-3 Magic' British parenting support
program applied to Japanese families, Journal of Japanese Society of Nursing Research., 35:91-101, 2012 (inJapanese) .

－ 99 －

8080

Community Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Senior Assistant Professor

SAKURAI Shihomi

Public health nursing, Family nursing

Senior Assistant Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse

School hygiene

Industrial health

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, activity of cmmunity organization, Nonsmoking education, School hygiene, Industrial health

Outline of Research
The community nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, and health maintenance.

Publications
Originals
8080B001

Y.Hamazaki, M.Nagai: Worries of independent older people regarding health and daily life: A survey of residents ofa rural town in Japan, J. Community Health Nurs., 29:225-235, 2012.

8080B002

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, H.Nakagawa: Relationship between participation in asecondary screening test for the frail elderly and new onset of the need for long-term care among the elderly in arural town, Japanese Journal of Public Health., 59:801-809, 2012 (in Japanese) .

－ 100 －

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Professor

KITAOKA Kazuyo

Assistant Professor

NAGAYAMA Yutaka

Field of Specialization
Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability
Minimization for the action limitation, psychiatric nursing for acutephase

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability, minimizing for the action limitation, physical restraint, seclusion

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has published the Japanese version of the Maslach Burnout
Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support thosepeople with mental disabiltiy. Particularly, we've been studying the nursing intervention to minimize the seclusion and thephysical restraint.

Publications
Originals
8085B001(K.Matsumoto), K.Sumino, H.Fukahori, K.Kitaoka, K.Kamibeppu, F.Nagamura: Stressor scale for clinical researchcoordinators: development and psychometric testing, J. Adv. Nurs., 68:1636-1645, 2012.

8085B002

K.Kitaoka, F.Ochiai, M.Uchida, T.Hashimoto, T.Terai: The effects of '1-2-3 Magic' British parenting support
program applied to Japanese families, Journal of Japanese Society of Nursing Research., 35:91-101, 2012 (inJapanese) .

8085B003(S.Masuda), K.Kitaoka, K.Ogino: Effects of item wording direction and grouping on psychological measures, The
Japanese Journal of Health Psychology, 25:31-41, 2012 (in Japanese) .

8085B004(K.Ohnishi), K.Kitaoka, M.Nakano, Y.Ohgushi, H.Tanaka, H.Fujii: Comparison of moral distress experienced bypsychiatric nurses in Japan and England, Journal of Japanese Society of Nursing Research., 35:101-107, 2012 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
8085I001

K.Kitaoka, S.Masuda, Y.Nagayama: Burnout among Japanese Nurse, The 9th International Conference with the
Global Network of WHO Collaborating Centres for Nursing and Midwifery, (Kobe, '12.07).

8085I002

K.Kitaoka, Y.Morikawa, H.Nakagawa, S.Masuda, Y.Nagayama: Mental health nursing research on the Japaneseemployees, 18th International Network for Psychiatric Nursing Research, (Oxford, '12.09).

8085I003(K.Ohnishi), K.Kitaoka, J.Nakahara: Model testing for the relationships among moral sensitivity, moral distress,
burnout, and coping, 18th International Network for Psychiatric Nursing Research, (Oxford, '12.09).

－ 101 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

KATO Kinko

Home Care Nursing, Public Health Nursing, Nursing History

Associate Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
support

Keywords of Research
Psychiatric Disorder, Community besed Workshop, "Recoverry"consept, psychatric service, Public health nursing
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced "Recoverry"consept, prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B001

S.Maeda, K.Tsukasaki, T.Kanda, T.Shimasaki, M.Moriyama, Y.Kohno, K.Kyuji: Supply of goods from hospitals to
outpatients practicing intermittent self-catheterization in Japan, Int J of Urol Nurs, 6:115-124, 2012.

8090B003

S.Maeda, T.Takiuti, T.Komatsu, Y.Kohno, K.Kyuji: Visiting nurse's experience of difficulty in performing catheter
management of long-term indwelling urinary catheter users, Journal of Japan Academy of Home Care., 16:68-75,
2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8090I001

S.Maeda, T.Takiuchi, T.Komatsu, Y.Kohno: Development of a training program for long-term bladder-catheter
management by visiting nurses, BAUN Annual Conference, (England, '12.11)，BAUN CONFERENCE &EXHIBITION 2012, 28, 2012.

－ 102 －

8095

Comprehensive Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing, Paliative Care, Chronic
Disease Nursing

Keywords of Researchnephrology, nursing, chronic kidney disease, hemodialysis
nursing, cancer survivors, care development
nursing, live donor, transplants

Outline of Research
Development of A Care for Cancer Survivors
Development of A Care for Live Donor for Transplants
Development of A Care for Patients under Chronic Kidney Disease or Hemodialysis－ 103 －

8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Professor

OKADA Masato

Peripheral nerve surgery, Trauma

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Professor

HONDA Ryumon

Environment and health, Epidemiology

Associate Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse,
Y.Suwazono, S.Kaneko, S.Sasaki, H.Nakagawa: Dietary glycemic index and risk of type 2 diabetes mellitus in
middle-aged Japanese men, Metabolism, 61:47-55, 2012.

8100B002

K.Ishigami, M.Okuro, Y.Koizumi, K.Satoh, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association ofsevere hypertension with pneumonia in elderly patients with acute ischemic stroke, Hypertens. Res., 35:648-653,
2012.

8100B003

Y.Noborisaka, M.Ishizaki, M.Nakata, Y.Yamada, R.Honda, H.Yokoyama, M.Miyao, M.Tabata: Cigarette smoking,proteinuria, and renal function in middle-aged Japanese men from an occupational population, Environ. HealthPrevent. Med., 17:147-156, 2012.

8100B004

K.Nakamura, M.Sakurai, M.Nishijo, Y.Morikawa, H.Nakagawa: Characteristics of smoking cessation in former
smokers in a rural area of Japan, Int J Prev Med, 3:459-465, 2012.

8100B005

M.Nishijo, T.Pham-The, H.Nakagawa, S.Maruzeni, T.N.A.Nguyen, V.L.Hoang, H.A.Tran, R.Honda, Y.Morikawa,
T.Kido, H.Nishijo: Impact of perinatal dioxin exposure on infant growth: A cross-sectional and longitudinal studies
in dioxin-contaminated areas in Vietnam, PLoS ONE, 7:e40273, 2012.
－ 104 －

8100B006

K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa: Overtime
work and blood pressure in normotensive Japanese male workers, Am. J. Hypertens., 25:979-985, 2012.

8100B007J.Yoshida, K.Iwabuchi, T.Matsui, T.Ishibashi, T.Masuoka, M.Nishio: Knockdown of stromal interaction molecule 1(STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid
carcinoma A431 cells, Biochem. Pharmacol., 84:1592-1603, 2012.

8100B008(The Emerging Risk Factors Collaboration), M.Sakurai, H.Nakagawa, K.Nakamura, Y.Morikawa: Adult height andthe risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis, Int.
J. Epidemiol., 41:1419-1433, 2012.

8100B009

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Self-reported speed of eating and 7-year risk of type 2 diabetes
mellitus in middle-aged Japanese men, Metabolism, 61:1566-1571, 2012.

8100B010

Y.Morikawa, M.Sakurai, K.Nakamura, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Correlation
between shift-work-related sleep problems and heavy drinking in Japanese male factory workers, Alcohol Alcohol.,doi:10.1093, 2012.

8100B011

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Serum gamma-glutamyltransferase and the risk of hyperuricemia: a 6-year prospective study inJapanese men, Horm. Metab. Res., 44:966-74, 2012.

8100B012

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, K.Yoshita, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Alcohol intake and the risk of hyperuricaemia:A 6-year prospective study in Japanese men, Nutr.
Metab. Cardiovasc. Dis., 22:989-996, 2012.

8100B013

Y.Morikawa, M.Tabata, T.Kido, Y.Koyama: Occupational class inequalities in behavioral and biological risk factors
for cardiovascular disease among workers in medium- and small-scale enterprises, Ind. Health, 50:529-539, 2012.

8100B014

PT.Tai, M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Loung, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LTM.Nguyet, LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Dioxin exposure and infant neurodevelopment – a follow up
study in Vietnamese infants, Organohalogen Compounds., 74:1369-1372, 2012.

8100B016

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, H.Nakagawa: Relationship between participation in asecondary screening test for the frail elderly and new onset of the need for long-term care among the elderly in arural town, Japanese Journal of Public Health., 59:801-809, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8100I001(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, H.Osada, E.Kubo, H.Sasaki, K.Sasaki: Factors influencing retinal image
contrast in eyes with retrodots (Reykjavik Eye Study), The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

8100I002

H.Osada, S.Shibata, R.Honda, N.Hatsusaka, M.Takahashi, M.Sasaki, Y.Hirata, N.Shibata, E.Kubo, H.Sasaki:
Pinguicula in urban office workers in Japan, The Association for Research in Vislon and Ophthalmology, (Florida,'12.05).

8100I003

M.Kojima, H.Sasaki, K.Sasaki, N.Hasanova, Y.Suzuki, M.Taki, K.Sasaki, K.Waki, S.Watanabe: Study of acuteocular damage threshold of 40 GHz millimeter wave, The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

8100I004

H.Sasaki, N.Hatsusaka, E.Shibuya, N.Mita, A.Okamoto, H.Osada, M.Kojima, E.Kubo, K.Sasaki: 12-year change ofcrystalline lens power by opacity type Reykjavik Eye Study, The Association for Research in Vislon andOphthalmology, (Florida, '12.05).

8100I005(K.Nogawa), Y.Suwazono, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Change in tubularmarker and calcium excretion after cadmium exposure, 48th Congress of the European-Societies-of-Toxicology(EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.
－ 105 －

8100I006(Y.Suwazono), K.Nogawa, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Biological half-life ofblood cadmium level of inhabitants in cadmium-polluted area, 48th Congress of the European-Societies-ofToxicology (EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

8100I007

TT.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, ATN.Nguyen, Loung.HV, Anh.TH, Y.Morikawa, T.Kido, H.Nishijo:
Dioxin exposure and infant neurodevelopment – a follow up study in Vietnamese infants., 32nd International
Symposium on Halogenated Persistent Organic Pollutants;Dioxin 2012, (Cairns, Australia, '12.08)，32nd
International Symposium on Halogenated Persistent Organic Pollutants; Dioxin 2012, 2012.

8100I008

K.Kitaoka, Y.Morikawa, H.Nakagawa, S.Masuda, Y.Nagayama: Mental health nursing research on the Japaneseemployees, 18th International Network for Psychiatric Nursing Research, (Oxford, '12.09).

8100I009(T.Okuno), M.Kojima, N.Hasanova, Y.Ishiba, Y.Suzuki, D.HSliney: Injury thresholds for IR-A laser exposure in the
rabbit lens, Asian pacific association of laser medicine & surgery, (Taiwan, '12.11).

8100I010

K.Iwai, S.Morimoto: CTCF is indispensable for the gene expression of estrogen receptors in the arterial smoothmuscle cell: Defensive mechanism against arteriosclerosis, American Heart Association Scientific Sessions 2012,(Los Angeles, '12.11)，American Heart Association Scientific Sessions 2012 Final Proguram, 201, 2012.

8100I011

K.Hiromura, H.Maeoka, K.Kitamura, M.Okada, T.Matsumoto: Treatment of athletic injuries of the posteriorsternoclavicular dislocation, Combined 33rd SICOT & 17th PAOA Orthopaedic World Conference, (Dubai, '12.11).

－ 106 －

Liberal Arts

8510

Life Science (Natural Science)

Faculty
Title

Name

Field of Specialization

Associate Professor

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Associate Professor

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)
piriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording
planaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell, lectin, galectin, β-galactoside, Xenopus, development, placenta, trophoblast

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies haveindicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to abetter treatment for cancer.
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: I sutdy physics education for a medical student
1.A computer support physics learning system. 2.Development of An experimental device. 3.University lectures on physics
for beginners.
１）-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
２）Electron microscopic analysis of the mechanisms of regeneration of planarians.

Publications
Originals
8510B001

T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata,
T.Takegami, H.Mogami, K.Yamaguchi, T.Nakamura, H.Otani, T.Hatta, H.Shoji: Expression pattern of Galectin 4
in rat placentation, Placenta, 33:885-887, 2012.

8510B002(S.Oomizu), T.Arikawa, T.Niki, T.Kadowaki, M.Ueno, N.Nishi, A.Yamauchi, T.Hattori, T.Masaki, M.Hirashima:
Cell surface galectin-9 expressing Th cells regulate Th17 and Foxp3+ treg development by galectin-9 secretion,
PLoS ONE, 7:e48574, 2012.

－ 107 －

8510B003

M.Murakami, T.Takata, M.Maeda, T.Takegami: The distribution and occurrence of mosquitoes during 2009-2011,
in the vicinity of homes in the city area, Ishikawa Prefecture, Japan, Urban Pest Management, 2:109-113, 2012 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
8510I001

Arikawa T, Simamura E, Shimada H, Hatta T, Shoji H: Analysis of the Galectin 4 expression during trophoblast
differentiation in rat placentation, International federation of Placenta association, (Hiroshima, '12.09).

－ 108 －

8530

Life Science(Physical Education)

Title

Name

Field of Specialization

Professor

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

Senior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Faculty

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program, improvement of physical fitness,
physical fitness, exercise prescription, soccer

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Tsuda : Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition, ourresearch focuses on improvememt of physical fitness through soccre for dhildren taing physical education in school.

Presentations at Conference
International Conference (Presentations)
8530I001

Ryosuke Tsuda, Akihiro Inoue, Koya Suzuki, Yasuhiko Marutani: The effect of the Soccer calss taking into accountimprovement in physical fitness:prcusing on game with changes in pitch area per player., 17th annual Congress of
the ECSS, (Belgium, '12.07).

－ 109 －

8550

Human Science(Humanities)

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKEDA Koichi

Philosophy, History of logic

Senior Assistant Professor

HONDA Kojiro

Ethics of technology

Keywords of Research
logic, metaphysics, form, content, predicate, category, deduction, induction, matter, being, substance, definion,
Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics,
Cognitive Science of Learning, History of Science, Philosophy of Science, Science Policy Studies

Outline of Research
TAKEDA:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.
HONDA:It is inquiring about the ethics of technology.
"Tradition of knowledge" has considered the problem what kind of responsibility occurs why in possible one and the sidewhich inherits knowledge again, by the mainly phenomenological technique.

Publications
Originals
8550B001

K.Takeda: On Aristotle's proofs through echthesis, Mem. Lib. Kanazawa Med. Univ., 40:1-17, 2012 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
8550I001

M.Kojima, N.Hasanova, Y.Suzuki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Ocular Temperature Measurement duringg 40GHz Exposure to Rabbit, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

8550I002(Y.Susuki), A.Koike, M.Kojima, K.Sasaki, K.Wake, N.Hasanova, M.Taki, S.Watanabe, K.Sasaki, H.Sasaki:
Computational and experimental dosimetry for rabbit eyes exposed to millimeter waves, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

8550I003

M.Kojima, N.Hasanova, Y.Suauki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Investigation of ocular temperature change in rabbits during 40 HGz band exposure, EMC EUROPE
2012, (Rome, '12.09).

8550I004

M.Kojima, N.Hasanova, Y.Suauki, K.Wake, K.Sasaki, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: In vestigation of acute ocular damagc threshold of 40 GHz millimeter wave on rabbit, 37th IRMMW-THz
2012, (Korea, '12.09).

－ 110 －

8570

Human Science(Mathematics)

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field.

Publications
Originals
8570B001(S.Ersoy), M.Tosun, H.Matsuda: Generalized mannheim curves in minkowski space-time E41, Hokkaido Math. J.,
41:441-461, 2012.

－ 111 －

8590

Human Science (Foreign Languages)

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

IKENAKA Masami

English Education

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical English, elearning
end of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the
English found in medical articles to determine the most commonly used
words, forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.

－ 112 －

Publications
Originals
8590B001

T.Burke steven: Deep Impact; Improving motivation in First class introductions, Mem. Lib. Kanazawa Med. Univ.,
40:27-32, 2012.

8590B002

W.Craig: Contributing to student motivation through lesson design, Mem. Lib. Kanazawa Med. Univ., 40:33-41,
2012.

Others
8590F001(D.Erickson), A.Suemitsu, Y.Shibuya, M.Tiede: Metrical structure and production of English rhythm, Phonetica,
69:179-189, 2012.

8590F002

A.Hara: A report on the two elective courses available in the first year of medical school －"Foreigun language
course" and "General human science" of 2009-2011－, Mem. Lib. Kanazawa Med. Univ., 40:19-26, 2012 (inJapanese) .

8590F003

Translated by M.Kouchi: Wilhelm Mommsen: Die politischen anschauungen Goethes (6), Mem. Lib. Kanazawa Med.
Univ., 40:43-53, 2012 (in Japanese) .

－ 113 －

U n ive r s i t y H o s p i t a l

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

Assistant Professor

SAITO Takashi

Treatment for metabolic syndrome

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer

Publications
Originals
0640B001

H.Yamada, T.Tahara, H.Shiroeda, R.Hayashi, T.Saito, M.Nakamura, M.Tsuchishima, M.Tsutsumi, T.Shibata,T.Arisawa: Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy, J.
Gastrointestin. Liver Dis., 21:139-143, 2012.

0640B002

T.Arisawa, T.Tahara, H.Shiroeda, Y.Matsue, T.Minato, T.Nomura, H.Yamada, R.Hayashi, T.Saito, K.Matsunaga,
T.Fukuyama, N.Hayashi, T.Otsuka, A.Fukumura, M.Nakamura, T.Shibata: Genetic polymorphisms of IL17A andpri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer, Hum. Immunol., 73:747752, 2012.

0640B003

T.Arisawa, T.Tahara, H.Shiroeda, H.Yamada, T.Nomura, R.Hayashi, T.Saito, T.Fukuyama, T.Otsuka,
M.Nakamura, N.Toshikuni, M.Tsuchishima, T.Shibata: NFKB1 polymorphism is associated with age-related gene
methylation in Helicobacter pylori-infected subjects, Int. J. Mol. Med., 30:255-262, 2012.

0640B004

R.Hayashi, T.Tahara, H.Shiroeda, Y.Matsue, T.Minato, T.Nomura, H.Yamada, T.Saito, K.Matsunaga,
T.Fukuyama, N.Hayashi, T.Otsuka, A.Fukumura, M.Nakamura, M.Tsutsumi, T.Shibata, T.Arisawa: Association ofgenetic polymorphisms in IL17A and IL17F with gastro-duodenal diseases, J. Gastrointestin. Liver Dis., 21:243249, 2012.

0640B005

R.Hayashi, T.Tahara, T.Yamaaki, T.Saito, K.Matsunaga, N.Hayashi, A.Fukumura, K.Ozaki, M.Nakamura,
H.Shiroeda, M.Tsutsumi, T.Shibata, T.Arisawa: -449 C>G polymorphism of NFKB1 gene, coding nuclear factorkappa-B, is associated with the susceptibility to ulcerative colitis, World J. Gastroenterol., 18:6981-6986, 2012.

Presentations at Conference
International Conference (Presentations)－ 114 －

0640I001

R.Hayashi, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, H.Yamada, T.Nomura, T.Saito, K.Matsunaga, N.Hayashi,
T.Otsuka, A.Fukumura, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi, T.Arisawa: The *910t>C
polymorphism of mafk gene is closely associated with the progression of chronic gastritis, Digestive Disease Week
2012, (San Diego, '12.05).

0640I002

T.Arisawa, T.Tahara, H.Shiroeda, T.Minato, Y.Matsue, R.Hayashi, T.Saito, T.Fukuyama, N.Hayashi,
K.Matsunaga, T.Otsuka, A.Fukumura, K.Ozaki, M.Nakamura, N.Toshikuni, M.Tsuchishima, M.Tsutsumi: The 449c>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility toulcerative colitis, Digestive Disease Week 2012, (San Diego, '12.05).

0640I003

H.Shiroeda, T.Tahara, R.Hayashi, T.Minato, Y.Matsue, H.Yamada, T.Nomura, T.Saito, K.Matsunaga, N.Hayashi,
T.Otsuka, A.Fukumura, K.Ozaki, N.Toshikuni, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Effects of -1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,on hypermrthylation of CDH1 gene in human gastricmucosa., Digestive Disease Week 2012, (San Diego, '12.05).

－ 115 －

0675

Health Evaluation Center

Faculty
Title

Name

Professor

KAWAHARA Hiromu Liver injury and oxidative stress

Professor

MATSUI Shinobu

Clinical cardiology

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

YASUDA Yukio

evidence-based health care

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/ Disease and Medical expenditure

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

Assistant Professor

OTA Kiyotaka

Radiology

Assistant Professor

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant
Professor(Additional Post)

HAYASAKI Hisae

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Field of Specialization

lifestyle-related disease

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001(R.Oka), K.Yagi, M.Sakurai, K.Nakamura, T.Moriuchi, S.Miyamoto, A.Nohara, M.Kawashiri, Y.Takeda,
M.Yamagishi: Insulin secretion and insulin sensitivity on the oral glucose tolerance test (OGTT) in middle-aged
Japanese, Endocr. J., 59:55-64, 2012.

0675B002

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse,
Y.Suwazono, S.Kaneko, S.Sasaki, H.Nakagawa: Dietary glycemic index and risk of type 2 diabetes mellitus in
middle-aged Japanese men, Metabolism, 61:47-55, 2012.

0675B003

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.
－ 116 －

0675B004

K.Nakamura, M.Sakurai, M.Nishijo, Y.Morikawa, H.Nakagawa: Characteristics of smoking cessation in former
smokers in a rural area of Japan, Int J Prev Med, 3:459-465, 2012.

0675B005

M.Nishijo, T.Pham-The, H.Nakagawa, S.Maruzeni, T.N.A.Nguyen, V.L.Hoang, H.A.Tran, R.Honda, Y.Morikawa,
T.Kido, H.Nishijo: Impact of perinatal dioxin exposure on infant growth: A cross-sectional and longitudinal studies
in dioxin-contaminated areas in Vietnam, PLoS ONE, 7:e40273, 2012.

0675B006

K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa: Overtime
work and blood pressure in normotensive Japanese male workers, Am. J. Hypertens., 25:979-985, 2012.

0675B007(A.Fujiyoshi), T.Ohkubo, K.Miura, Y.Murakami, S.Nagasawa, T.Okamura, H.Ueshima: Blood pressure categories
and long-term risk of cardiovascular disease according to age group in Japanese men and women, Hypertens. Res.,
35:947-953, 2012.

0675B008(A.Fujiyoshi), T.Ohkubo, K.Miura, Y.Murakami, S.Nagasawa, T.Okamura, H.Ueshima, EPOCH-JAPAN ResearchGroup, H.Nakagawa: Blood pressure categories and long-term risk of cardiovascular disease according to age
group in Japanese men and women, Hypertens. Res., 35:947-953, 2012.

0675B009(The Emerging Risk Factors Collaboration), M.Sakurai, H.Nakagawa, K.Nakamura, Y.Morikawa: Adult height andthe risk of cause-specific death and vascular morbidity in 1 million people: individual participant meta-analysis, Int.
J. Epidemiol., 41:1419-1433, 2012.

0675B010

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Self-reported speed of eating and 7-year risk of type 2 diabetes
mellitus in middle-aged Japanese men, Metabolism, 61:1566-1571, 2012.

0675B011(K.Ueda), S.Nagasawa, H.Nitta, K.Miura, H.Ueshima, for the NIPPON DATA80 research group, H.Nakagawa:Exposure to particulate matter and long-term risk of cardiovascular mortality in Japan : NIPPON DATA80, J.
Atheroscler. Thromb., 19:246-254, 2012.

0675B012

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, S.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Serum gamma-glutamyltransferase and the risk of hyperuricemia: a 6-year prospective study inJapanese men, Horm. Metab. Res., 44:966-74, 2012.

0675B013(N.Takashima), T.Ohkubo, K.Miura, T.Okamura, Y.Murakami, A.Fujiyoshi, S.Nagasawa, A.Kadota, Y.Kita,
N.Miyagawa, T.Hisamatsu, T.Hayakawa, A.Okayama, H.Ueshima: Long-term risk of BP values above normal for
cardiovascular mortality: a 24-year observation of Japanese aged 30 to 92 years, J. Hypertens., 30:2299-2306,
2012.

0675B014

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, K.Yoshita, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Alcohol intake and the risk of hyperuricaemia:A 6-year prospective study in Japanese men, Nutr.
Metab. Cardiovasc. Dis., 22:989-996, 2012.

0675B015

K.Nakamura, H.Nakagawa, M.Sakurai, Y.Murakami, F.Irie, A.Fijiyoshi, T.Okamura, K.Miura, H.Ueshima, for the
EPOCH-JAPAN research group: Influence of smoking combined with another risk factor on the risk of mortality
from coronary heart disease and stroke: Pooled analysis of 10 Japanese cohort studies, Cerebrovasc. Dis., 33:480491, 2012.

0675B016(R.Oka), K.Yagi, M.Sakurai, K.Nakamura, S.Nagasawa, S.Miyamoto, A.Nohara, M.Kawashiri, K.Hayashi, Y.Takeda,
M.Yamagishi: Impact of visceral adipose tissue and subcutaneous adipose tissue on insulin resistance in middleaged Japanese, J. Atheroscler. Thromb., 19:814-822, 2012.

0675B017

PT.Tai, M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Loung, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LTM.Nguyet, LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Dioxin exposure and infant neurodevelopment – a follow up
study in Vietnamese infants, Organohalogen Compounds., 74:1369-1372, 2012.

0675B018

M.Nishijo, PT.Tai, NM.Nui, NTN.Anh, NM.Hai, S.Maruzeni, TN.Nghi, PT.Phoung, H.Nishijo, TH.Anh, HV.Loung,
T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Effects of dioxins exposure on social emotional behavior of children
living in a hot spot area, Vietnam, Organohalogen Compounds., 74:1332-1335, 2012.

0675B019(T.Kido), R.Okamoto, HD.Manh, XL.Sun, NH.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, DV.Tung, DD.Nhu, NN.Hung, LK.Son: Dioxin in breast milk of Vietnamese mothers andsteroid hormone in saliva of their infants, Organohalogen Compounds., 74:1361-1364, 2012.
－ 117 －

0675B020

S.Nagasawa, T.Okamura, H.Iso, A.Tamakoshi, M.Yamada, M.Watanabe, Y.Murakami, K.Miura, H.Ueshima, for the
EPOCH-JAPAN Research Group: Relation between serum total cholesterol level and cardiovascular diseasestratified by sex and age group: A pooled analysis of 65 594 individuals from 10 cohort studies in Japan, J. Am.
Heart Assoc., 1:e001974, 2012.

0675B021(TC.Turin), Y.Murakami, K.Miura, N.Rumana, Y.Kita, T.Hayakawa, T.Okamura, A.Okayama, H.Ueshima, and of
the NIPPON DATA80/90 Research Group, H.Nakagawa: Hypertension and life expectancy among Japanese:
NIPPON DATA80, Hypertens. Res., 35:954-958, 2012.

0675B022(A.Fujiyoshi), T.Ohkubo, K.Miura, Y.Murakami, S.Nagasawa, T.Okamura, H.Ueshima, for the Evidence for
Cardiovascular Prevention From Observational Cohorts in Japan (EPOCH-JAPAN) Research Group, H.Nakagawa:Blood pressure categories and long-term risk of cardiovascular disease according to age group in Japanese men
and women, Hypertens. Res., 35:947-953, 2012.

0675B023(Y.Nakamura), T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, T.Ohkubo, K.Miura, F.Kasagi, K.Kodama,
A.Okayama, H.Ueshima, and for the NIPPON DATA80 Research Group, H.Nakagawa: Prognostic values ofclockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects : A 24-year follow-up of
the national integrated project for prospective observation of noncommunicable disease and its trends in the aged,
1980-2004(NIPPON DATA80)., Circulation, 125:1226-1233, 2012.

0675B024

Y.Hamazaki, Y.Morikawa, K.Nakamura, S.Morimoto, H.Nakagawa: Relationship between participation in asecondary screening test for the frail elderly and new onset of the need for long-term care among the elderly in arural town, Japanese Journal of Public Health., 59:801-809, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0675I001

K.Nakamura, H.Nakagawa, M.Sakurai, Y.Murakami, F.Irie, A.Fujiyoshi, T.Okamura, K.Miura, H.Ueshima:
Smoking, its combination with another risk factor and the risk of mortality from coronary heart disease and stroke:a pooled analysis of 10 Japanese cohort studies, The XVI International Symposium on Atherosclerosis (ISA2012),(Sydney,Australia, '12.03).

0675I002(K.Nogawa), Y.Suwazono, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Change in tubularmarker and calcium excretion after cadmium exposure, 48th Congress of the European-Societies-of-Toxicology(EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

0675I003(Y.Suwazono), K.Nogawa, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Biological half-life ofblood cadmium level of inhabitants in cadmium-polluted area, 48th Congress of the European-Societies-ofToxicology (EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

－ 118 －

Medical Research Institute7100

Department of Life Science

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle, transformation

Professor(Additional Post)

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TASAKI Takafumi

Physiological functions of the N-end rule pathway and the underlying
molecular mechanisms

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Assistant Professor

MURAKAMI Manabu

Pathogenicity of flavivirus isolated from the field-collectedmosquitoes

Researcher

NAKAMURA Yuka

Molecular and Cellular Biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, "transcriptome, proteome, apoptosis, ultra micro structure", "mouse germ cells, DNA repair, fibroblast
growth factor", tumor growth angiogenesis

Outline of Research
１．Study on viral replication and pathogenicity
２．Molecular mechanism of carcinogenesis and metastasis
３．Research on plolyploidization and polyploid cells
４．Analyses of transcription and mRNA decay

Publications
Originals
7100B001

Q.Zhang, K.Tanaka, P.Sun, M.Nakata, R.Yamamoto, K.Sakimura, M.Matsui, N.Kato: Suppression of synaptic
plasticity by cerebrospinal fluid from anti-NMDA receptor encephalitis patients, Neurobiol. Dis., 45:610-615,
2012.

7100B002(N Ota), F Takano, S Muroga, T Kawabata, Y.Ishigaki, N Yahagi, T Ohta: Garlic extract and its selectedorganosulphur constituents promote ileal immune responses ex vivo., J. Funct. Foods, 4:243-252, 2012.

7100B003

T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami,
T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo: Glycogen synthase kinase 3βinhibition sensitizes
pancreatic cancer cells to gemcitabine, J. Gastroenterol., 47:321-333, 2012.

－ 119 －

7100B004

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.

7100B005(S. Nukuzuma), M. Kameoka, S. Sugiura, K. Nakamichi, C. Nukuzuma, I. Miyoshi, T.Takegami: Ecogenous humanimmunodeficiency virus-1 protein, tat enhances replication of JC virus efficiently in neuroblastoma cell lines, J.
Med. Virol., 84:555-561, 2012.

7100B006(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

7100B007

T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata,
T.Takegami, H.Mogami, K.Yamaguchi, T.Nakamura, H.Otani, T.Hatta, H.Shoji: Expression pattern of Galectin 4
in rat placentation, Placenta, 33:885-887, 2012.

7100B008

S.Zhang, T.S.Kim, Y.Dong, S.Kanazawa, M.Kawaguchi, N.Gao, H.Minato, T.Takegami, T.Nojima, K.Asai, Y.Miura:
AT motif binding factor 1 (ATBF1) is highly phosphorylated in embryonic brain and protected from cleavage by
calpain-1, Biochem. Biophys. Res. Commun., 427:537-541, 2012.

7100B009

T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi: Characterization of proteinssecreted by pancreatic cancer cells with anticancer drug treatment in vitro, Oncol. Rep., 28:1968-1976, 2012.

7100B010(H.Tuncel), S.Tanaka, S.Oka, S.Nakai, R.Fukutomi, M.Okamoto, T.Ota, H.Kaneko, M.Tatsuka, F.Shimamoto:
PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal
cancer development, Int. J. Oncol., 41: 2079-2086, 2012.

7100B011

K. Fujikawa-Yamamoto, T. Ota, M. Miyagoshi, H. Yamagishi: Pluripotency of a polyploid H1 (ES) cell system
without leukemia inhibitory factor., Cell Prolif., 45:140-147, 2012.

7100B012

K. Fijikawa-Yamamoto, T. Ota, M. Miyagoshi, H. Yamagishi: Effects of etoposide on the proliferation ofhexapolyploid H1 (ES) cells., Hum. Cell., 25:45-50, 2012.

7100B013(T.Kezuka), Y.Usui, N.Yamakawa, Y.Matsunaga, R.Matsuda, M.Masuda, H.Utsumi, K.Tanaka, H.Goto:
Relationship between NMO-Antibody and Anti-MOG Antibody in optic neuritis, J. Neuroophthalmol., 32:107-110,
2012.

7100B014(A.Nagaishi), T.Tani, M.Takagi, M.Tanaka, K.Sakimura, M.Matsui, K.Tanaka: Anti-aquaporin 4 antibody binding
character in clinical subtypes of neuromyelitis optica, Clin. Exp. Neuroimmunol., 3:109-115, 2012.

7100B015(K.Takahashi), K.Tanaka: Clinical and magnetic resonance imaging features of multiple sclerosis with autoreactive
antibodies in Ishikawa prefecture,Japan, J. Neuroimmunol., 250:111-114, 2012.

7100B016(K.Fujita), T.Yuasa, Y.Takahashi, K.Tanaka, S.Hashiguchi, K.Adachi, Y.Izumi, R.Kaji: Detection of anti-glutamate
receptor ε2 and anti-N-methyl-D-aspartate receptor antibodies in a patient with sporadic creutzfeldt-jakob
disease, J. Neurol., 259:985-988, 2012.

7100B017(M.Yoshimura), K.Monma, N.Suzuki, M.Aoki, T.Kumamoto, K.Tanaka, H.Tomimitsu, S.Nakano, M.Sonoo,
J.Shimizu, K.Sugie, H.Nakamura, Y.Oya, Y.Hayashi, M.C.V.Malicdan, S.Noguchi, M.Murata, I.Nishino:
Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene
result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain
mutations, J. Neurol. Sci., 318:100-105, 2012.

7100B018(K.Fujita), T.Yuasa, Y.Takahashi, K.Tanaka, W.Sako, H.Koizumi, Y.Iwasaki, M.Yoshida, Y.Izumi, R.Kaji:
Antibodies to N-methyl-D-aspartate glutamate receptors in creutzfeldt-jakob disease patients, J. Neuroimmunol.,
251:90-93, 2012.

7100B019(K.Tsutsui), T.Kanbayashi, K.Tanaka, S.Boku, W.Ito, J.Tokunaga, A.Mori, Y.Hishikawa, T.Shimizu, S.Nishino:Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features,
BMC psychiatry, 12:37 ,1-9, 2012.

7100B020(Y.Ando), H.Shimazaki, M.Sawada, K.Yoshida, S.Sakamoto, K.Tanaka, I.Nakano: An Anti-NMDA-R
encephalitis/encephalopathy that was diagnosed as catatonia -An 18-year-old man with effective modified
electroconvulsive therapy-, Neurol Therap, 29:767-771, 2012 (in Japanese) .
－ 120 －

7100B021

M.Murakami, T.Takata, M.Maeda, T.Takegami: The distribution and occurrence of mosquitoes during 2009-2011,
in the vicinity of homes in the city area, Ishikawa Prefecture, Japan, Urban Pest Management, 2:109-113, 2012 (inJapanese) .

7100B022(M.Tanaka), R.Motoyama, M.Tahara, K.Tanaka: Brain MRI findings in Japanese patients with clinically isolated
syndrome, Clinical Neurology, 52:725-729, 2012 (in Japanese) .

Reviews
7100C001

H.Umehara, K.Okazaki, Y.Masaki, M.Kawano, M.Yamamoto, T.Saeki, S.Matsui, T.Sumida, T.Mimori, Y.Tanaka,
K.Tsubota, T.Yoshino, S.Kawa, R.Suzuki, T.Takegami, N.Tomosugi, N.Kurose, Y.Ishigaki, A.Azumi, M.Kojima,
S.Nakamura, D.Inoue: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details, Mod.
Rheumatol., 22:1-14, 2012.

Case Reports
7100D001(A.Uruha), Y.Kitazawa, M.Kuroda, K.Tanaka, R.Koide: Anti-NMDAR encephalitis in small-cell lung cancer: A casereport, Clin. Neurol. Neurosurg., 114:260-261, 2012.

7100D002(Y.Ariizumi), T.Ozawa, T.Tokutake, I.Kawachi, M.Hirose, S.Katada, S.Igarashi, K.Tanaka, M.Nishizawa: Chorea as
the first sign in a patient with elderly onset systemic lupus erythematosus, Case Report. Neurol. Med., 317082 ,13, 2012.

7100D003(T.Shirafuji), F.Kanda, K.Sekiguchi, M.Higuchi, H.Yokozaki, K.Tanaka, H.Takahashi, T.Toda: A case of Anti-Huassociated paraneoplastic encephalomyelitis with esophageal small cell carcinoma, Intern. Med., 51:2423-2427,
2012.

7100D004

S.Nagayama, N.Minato, M.Nakata, M.Kaito, M.Nakanishi, K.Tanaka, M.Arai, H.Akiyama, M.Matsui: Novel FUS
mutation in patients with sporadic amyotrophic lateral sclerosis and corticobasal degeneration, J. Clin. Neurosci.,
19:1738-1739, 2012.

7100D006(Y.Takado), T.Shimohata, I.Kawauchi, K.Tanaka, M.Nishizawa: Successful treatment of neuroborreliosis withcombined administration of antibiotics and steroids : A case report, Clinical Neurology, 52:411-415, 2012 (inJapanese) .

7100D007(A.Kubota), T.Tajima, S.Narukawa, M.Yamazato, H.Fukaura, Y.Takahashi, K.Tanaka, J.Shimizu, K.Nomura: AntiMa2, anti-NMDA-receptor and anti-GluRε2 limbic encephalitis with testicular seminoma: short-term memory
disturbance, Clinical Neurology, 52:666-671, 2012 (in Japanese) .

7100D008(K.Tsutsui), T.Kanbayashi, K.Tanaka, S.Boku, W.Ito, J.Tokunaga, A.Mori, Y.Hishikawa, T.Shimizu, S.Nishino:Anti-NMDA-receptor antibody detected in encephalitis, schizophrenia, and narcolepsy with psychotic features,
Jpn. J. Gen. Hosp. Psychiatry, 24:40-50, 2012 (in Japanese) .

Short Communications
7100E001(K.Yanaga), N.Maekawa, N.Shimomura, Y.Ishigaki, Y.Nakamura, T.Takegami, N.Tomosugi, S.Miyazawa,
S.Kuwabata: Use of ionic liquid in fungal taxonomic study of ultrastructure of basidiospore ornamentation,
Mycological Prog., 11:343-347, 2012.

Others
7100F001(M.Tahara), R.Ito, K.Tanaka, M.Tanaka: Cortical and leptomeningeal involvement in three cases of neuromyelitis
optica, Eur. J. Neurol., 19:47-48, 2012.

Presentations at Conference
International Conference (Presentations)－ 121 －

7100I001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, E.Kubo, H.Sasaki, H.Yonekura: Ultraviolet Binduced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, International
Conference on The Lens, (Hawaii, '12.01).

7100I002

K. Fijikawa-Yamamoto, T. Ota, M. Miyagoshi, H. Yamagishi: Polyploid H1 embryonic stem cells with nanog overexpression., ISAC XXVII International Congress, (Leipzig, '12.06)，Cytometry, 2012.

7100I003

T.Takegami, M.Murakami, Y.Ishigaki, T.Tasaki, Y.Oikawa, K.Kamimura: Distribution of Japanese encephalitis virus(JEV) in Ishikawa Japan , and IFN-sensitivity of JEV Ishikawa strain (genotype 1), 46th US Japan Cooperative
Medical Science Program, (Beppu, '12.06).

7100I004

Y.Ishigaki, Y.Nakamura, T.Takehara, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Ionic liquid enables
simple and rapid sample preparation of human culturing cells for scanning electron microscope (SEM) analysis, 14th
International Congress of Histochemistry and Cytochemistry, (Kyoto, '12.08).

7100I005

J.Yamakawa, Y.Ishigaki, J.Moriya, Y.Motoo, T.Takegami, J.Kobayashi: The Kampo Medicenes Have Diffierent
Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes, 13th International Congress of
the Society for Ethnopharmacology, (Austria, '12.08).

7100I006

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Neuroscience 2012 -Society for Neuroscience-, (New Orleans, '12.10).

7100I007

K.Tanaka, Y.Li, Y.Ishigaki, T.Takegami, M.Tanaka, M.Matsui, N.Kato: Effects of anti-NMDA receptor antibodies
from the patients with NMDA receptor encephalitis on the neurons, 11th International Congress of
Neuroimmunology, (Boston, '12.11).

－ 122 －

7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor(Additional Post)

MATSUI Shinobu

Clinical Cardiology

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine

Senior AssistantProfessor(Additional Post)SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Research Associate

MURANO Hidekazu

Cardial histology and immunohistochemistry

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype

Outline of Research
１．Heart failure by autoimmune pathway related with G-protein
２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
３．The role of AGE in the prevention of lifestyle related disease
４．Clinical research for the diagnosis and treatment of pancreatic cancer
５．Development and clinical application of fetal DNA diagnosis using mother’s blood
６．Genetic diagnosis and analysis of hereditary developmental disability
７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Books
7200A002

Y.Motoo, QS.Xia, N.Nakaya, T.Shimasaki, H.Nakajima: Stress responses of pancreatic cancer cells and theirsignificance in invasion and metastasis, The Primo Vascular System: Its Role in Cancer and Regeneration, 213-217,
Springer, New York, 2012.

7200A003(T.Minamoto), M.Kotake, M.Nakada, T.Shimasaki, Y.Motoo, Kawakami K: Distinct pathologic role for glycogensynthase kinase 3β in colorectal cancer progression, Colorectal cancer biology – from genes to tumor, 107-134,
InTech, Croatia, 2012.

－ 123 －

Publications
Originals
7200B001

Y.Fujita, H.Yanagida, T.Mimori, Z.Jin, T.Sakai, T.Kawanami, T.Sawaki, Y.Masaki, T.Fukushima, T.Okazaki,
H.Umehara: Prevention of fasting-mediated bone marrow atrophy by leptin administration, Cell. Immunol., 273:5258, 2012.

7200B002(H.Kawabata), S.Doisaki, A.Okamoto, T.Uchiyama, S.Sakamoto, A.Hama, K.Hosoda, J.Fujikura, H.Kanno, H.Fujii,
N.Tomosugi, K.Nakao, S.Kojima, A.Takaori-Kondo: A Case of congenital dyserythropoietic anemia type 1 in a
Japanese adult with a CDANI gene mutation and an inappropriately low serum hepcidin-25 level, Intern. Med.,
51:917-920, 2012.

7200B003(K.Hwa Park), T.Sawada, T.Kosuge, J.Kita, M.Shimoda, N.Tomosugi, K.Kubota: Surgical inflammation induces
hepcidin productioin after abdominal surgery, World J. Surg., 36:800-806, 2012.

7200B004

T.Shimasaki, Y.Ishigaki, Y.Nakamura, T.Takata, N.Nakaya, H.Nakajima, I.Sato, X.Zhao, A.Kitano, K.Kawakami,
T.Tanaka, T.Takegami, N.Tomosugi, T.Minamoto, Y.Motoo: Glycogen synthase kinase 3βinhibition sensitizes
pancreatic cancer cells to gemcitabine, J. Gastroenterol., 47:321-333, 2012.

7200B005

Y.Ishigaki, Y.Nakamura, Y.Oikawa, Y.Yano, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Observation oflive ticks (Haemaphysalis flava) by scanning electron microscopy under high vacuum pressure, PLoS ONE,
7:e32676 1-6, 2012.

7200B006

I.Sato, N.Nakaya, T.Shimasaki, H.Nakajima, Y.Motoo: Prediction of docetaxel monotherapy-induced neutropenia
based on the monocyte percentage, Oncol. Lett., 3:860-864, 2012.

7200B007(Y.Ishibashi), T.Matsui, M.Takeuchi, S.Yamagishi: Beneficial effects of metformin and irbesartan on advanced
glycation end products (AGEs)-RAGE-induced proximal tubular cell injury., Pharmacol. Res., 65:297-302, 2012.

7200B008(E.Lafont), R.Dupont, N.Andrieu-Avadie, T.Okazaki, K.Schulze-Osthoff, T.Levade, H.Benoist, B.Séqui: Orderingof ceramide formation and caspase-9 activation in CD95L-induced jurkat leukemia T cell apoptosis, BBA-MOL
CELL BIOL L, 1821:684-693, 2012.

7200B009(J.Takino), S.Yamagishi, M.Takeuchi: Glycer-AGEs-RAGE signaling enhances the angiogenic potential of HCC byupregulating VEGF expression., World J. Gastroenterol., 18:1781-1788, 2012.

7200B010(H.Nakajima), K.Koizumi, T.Tanaka, Y.Ishigaki, Y.Yoshitake, H.Yonekura, T.Sakuma, T.Fukushima, H.Umehara,
S.Ueno, T.Minamoto, Y.Motoo: Loss of HITS(FAM107B) expression in cancers of multiple organs: tissue
microarray analysis, Int. J. Oncol., 41:1347-1357, 2012.

7200B011(R.Giulia), S.Pelucchi, R.Mariani, N.Tomosugi, G.L.Modignani, M.Pozzi, E.Nemeth, T.Ganz, H.Hayashi,
D.Barisani, A.Piperno: Hepcidin expression in iron overload diseases is variably modulated by circulating factors.,
PLoS ONE, 7:e36425, 2012.

7200B012(S.Asano), K.Kitatani, M.Taniguchi, M.Hashimoto, K.Zama, S.Mitsutake, Y.Igarashi, H.Takeya, J.Kigawa,
A.Hayashi, H.Umehara, T.Okazaki: Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid
rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway, Mol. Cell. Biol., 32:3242-3252,
2012.

7200B013(A.Ojima), T.Matsui, S.Maeda, M.Takeuchi, S.Yamagishi: Glucose-dependent insulinotropic polypeptide (GIP)
inhibits signaling pathways of advanced glycation end products (AGEs) in endothelial cells via its anti-oxidative
properties., Horm. Metab. Res., 44:501-505, 2012.

7200B014(A.Hattori), H.Miyajima, N.Tomosugi, Y.Tatsumi, H.Hayashi, S.Wakusawa: Clinicopathological study of Japanesepatients with genetic iron overload syndromes, Pathol. Int., 62:612-618, 2012.

7200B015(A.Hattori), N.Tomosugi, Y.Tatsumi, A.Suzuki, K.Hayashi, Y.Katano, Y.Inagaki, T.Ishikawa, H.Hayashi, H.Goto,
S.Wakusawa: Identification of a novel mutation in the HAMP gene that causes non-detectable hepcidin molecules
in a Japanese male patient with juvenile hemochromatosis., Blood Cells Mol. Dis., 48:179-182, 2012.

－ 124 －

7200B016(N.Sugimoto), O.Shido, K.Matsuzaki, T.Ohno-Shosaku, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami,
Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara: Cellular heat acclimation regulates cell
growth, cell morphology, mitogen-activated protein kinase activation, and expression of aquaporins in mouse
fibroblast cells, Cell. Physiol. Biochem., 30:450-457, 2012.

7200B017

T.Arikawa, E.Shimamura, H.Shimada, N.Nishi, T.Tatsuno, Y.Ishigaki, N.Tomosugi, C.Yamashiro, T.Hata,
T.Takegami, H.Mogami, K.Yamaguchi, T.Nakamura, H.Otani, T.Hatta, H.Shoji: Expression pattern of Galectin 4
in rat placentation, Placenta, 33:885-887, 2012.

7200B018(Y.Sakuraoka), T.Sawada, T.shiraki, K.Park, Y.Sakurai, N.Tomosugi, K.Kubota: Analysis of hepcidin expression: insitu hybridization and quantitative polymerase chain reaction from paraffin sections., World J. Gastroenterol.,
18:3727-3731, 2012.

7200B019(T.Uehata), N.Tomosugi, T.Shoji, Y.Sakaguchi, A.Suzuka, T.Kaneko, N.Okada, R.Yamamoto, Y.Nagasawa, K.Kato,
Y.Isaka, H.Rakugi, Y.Tsubakihara: Serum hepcidin-25 levels and anemia in non-dialysis chronic kidney disease
patients :a cross-sectional study, Nephrol. Dial. Transplant., 27:1076-83, 2012.

7200B020(MH.Lu), M.Takemoto, K.Watanabe, H.Luo, M.Nishimura, M.Yano, H.Tomimoto, T.Okazaki, Y.Oike, WJ.Song:
Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice, J.
Physiol. (Lond.), 590:4029-4044, 2012.

7200B021(Y.Ishibashi), S.Yamagishi, T.Matsui, K.Ohta, R.Tanoue, M.Takeuchi, S.Ueda, K.Nakamura, S.Okuda: Pravastatin
inhibits advanced glycation end products (AGEs)-induced proximal tubular cell apoptosis and injury by reducing
receptor for AGEs (RAGE) level., Metabolism, 61:1067-1072, 2012.

7200B022(K.Zama), A.Mitsutake, K.Watanabe, T.Okazaki, Y.Igarashi: A sensitive cell-based method to screen for selective
inhibitors of SMS1 or SMS2 using HPLC and a fluorescent substrate, Chem. Phys. Lipids, 165:760-768, 2012.

7200B023

T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, T.Nakamura, T.Sato, Y.Fujita, M.Tanaka, Y.Masaki,
T.Fukushima, Y.Hirose, M.Taniguchi, N.Sugimoto, T.Okazaki, H.Umehara: Skewed production of IL-6 and TGFβ
by cultured salivary gland epithelial cells from patients with Sjögren's syndrome, PLoS ONE, 7:e45689 1-5, 2012.

7200B024

M.Taniguchi, K.Kitatani, T.Kondo, M.Hashimoto-Nishimura, S.Asano, A.Hayashi, S.Mitsutake, Y.Igarashi,
H.Umehara, H.Takeya, J.Kigawa, T.Okazaki: Regulation of autophagy and its associated cell death by sphingolipid
rheostat: reciprocal role of ceramide and sphingosine-1-phosphate in the mTOR pathway., J. Biol. Chem.,
287:39898-39910, 2012.

7200B025

S.Maeda, K.Tsukasaki, T.Kanda, T.Shimasaki, M.Moriyama, Y.Kohno, K.Kyuji: Supply of goods from hospitals to
outpatients practicing intermittent self-catheterization in Japan, Int J of Urol Nurs, 6:115-124, 2012.

7200B026(Y.Ishibashi), T.Matsui, M.Takeuchi, S.Yamagishi: Metoformin inhibits advanced glycation end products (AGEs)induced renal tubular cell injury by suppressing reactive oxygen species generation via reducing receptor for AGEs
(RAGE) expression., Horm. Metab. Res., 44:891-895, 2012.

7200B027(N.Tahara), S.Yamagishi, A.Tahara, M.Takeuchi, T.Imaizumi: Serum levels of pigment epithelium-derived factor, anovel marker of insulin resistance, are independently associated with fasting apolipoprotein B48 levels in humans,
Clin. Biochem., 45:1404-1408, 2012.

7200B028(T.Kamai), N.Tomosugi, H.Abe, Y.Kaji, T. Oyama, K. Yoshida: Protein Profiling of Blood Samples from Patientswith Hereditary Leiomyomatosis and Renal Cell Cancer by Surface-Enhanced Laser Desorption/Ionization Timeof-Flight Mass Spectrometry., Int. J. Mol. Sci., 13:14518-14532, 2012.

7200B029

T.Takata, Y.Ishigaki, T.Shimasaki, H.Tsuchida, Y.Motoo, A.Hayashi, N.Tomosugi: Characterization of proteinssecreted by pancreatic cancer cells with anticancer drug treatment in vitro, Oncol. Rep., 28:1968-1976, 2012.

7200B030(N.Tahara), S.Yamagishi, M.Takeuchi, A.Honda, A.Tahara, Y.Nitta, N.Kodama, M.Mizoguchi, H.Kaida,
M.Ishibashi, N.Hayabuchi, T.Matshui, T.Imaizumi: Positive association between serum level of glyceraldehydederived advanced glycation end products (AGEs) and vascular inflammation evaluated by 18F-fluorodeoxyglucose
positron emission tomography (FDG-PET)., Diabetes Care., 35:2618-2625, 2012.

7200B031(C.Mizumoto), H.Kawabata, T.Uchiyama, S.Sakamoto, J.Kanda, N.Tomosugi, A.Takanori-Kondo: Acidic milieu
augments the expression of hepcidin, the central regulator of iron homeostasis., Int. J. Hematol., 96:701-709,
2012.
－ 125 －

7200B032(K.Niihata), N.Tomosugi, T.Uehata, T.Shoji, K.Mitsumoto, M.Shimizu, H,Kawabata, Y.Sakaguchi, A.Suzuki,
T.Hayashi, N.Okada, Y.Isaka, H.Rakugi, Y.Tsubakihara: Serum hepcidin-25 levels predict the progression of renal
anemia in patients with non-dialysis chronic kidney disease., Nephrol. Dial. Transplant., 27:4378-85, 2012.

7200B033

L.Dong, K.Watanabe, M.Itoh, C.Huan, X.Tong, T.Nakamura, M.Miki, H.Iwao, A.Nakajima, T.Sakai, T.Kawanami,
T.Sawaki, Y.Masaki, T.Fukushima, Y.Fujita, M.Tanaka, M.Yano, T.Okazaki, H.Umehara: CD4＋T-cell
dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin syｎthase 1-knockout mice, Int. Immunol., 24:327-337, 2012.

7200B034

M.Murakami, T.Takata, M.Maeda, T.Takegami: The distribution and occurrence of mosquitoes during 2009-2011,
in the vicinity of homes in the city area, Ishikawa Prefecture, Japan, Urban Pest Management, 2:109-113, 2012 (inJapanese) .

Reviews
7200C001

Y.Motoo: Traditional Japanese medicine in the multi-disciplinary approach to cancer, J. Trad. Med., 29:104-107,
2012.

7200C002

H.Umehara, K.Okazaki, Y.Masaki, M.Kawano, M.Yamamoto, T.Saeki, S.Matsui, T.Sumida, T.Mimori, Y.Tanaka,
K.Tsubota, T.Yoshino, S.Kawa, R.Suzuki, T.Takegami, N.Tomosugi, N.Kurose, Y.Ishigaki, A.Azumi, M.Kojima,
S.Nakamura, D.Inoue: A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details, Mod.
Rheumatol., 22:1-14, 2012.

7200C003

T.Shimasaki, A.kitano, Y.Motoo, T.Minamoto: Aberrant glycogen synthase kinase 3β in the development ofpancreatic cancer, J. Carcinog., 11:15 ,1-9, 2012.

7200C005

M.Takeuchi: AGEs and Liver Disease, Anti-Aging Med., 8:55-61, 2012 (in Japanese) .

Case Reports
7200D001

T.Fukushima, H.Kawabata, T.Sawaki, T.Satoh, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, M.Miki, Y.Fujita,
M.Tanaka, T.Kawanami, Y.Masaki, T.Okazaki, H.Umehara: Low-dose cytarabine plus aclarubicin for patients withpreviously untreated acute myeloid leukemia or high-risk myelodysplastic syndrome ineligible for standard-dose
cytarabine plus anthracline, Anticancer Res., 32:1347-1354, 2012.

7200D002

T.Fukushima, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita,
M.Tanaka, Y.Masaki, T.Okazaki, H.Nakajima, Y.Motoo, H.Umehara: Daily 500mg valacyclovir is effective forprevention of varicella zoster virus reactivation in patients with multiple myeloma treated with bortezomib,
Anticancer Res., 32:5437-5440, 2012.

Short Communications
7200E001

Y. Niida, M. Kuroda, Y. Mitani, A. Yokoi, M.Ozaki: Paternal uniparental isodisomy of chromosome 22 in a patientwith metachromaatic leukodystrophy, J. Hum. Genet., 57:687-690, 2012.

7200E002(K.Yanaga), N.Maekawa, N.Shimomura, Y.Ishigaki, Y.Nakamura, T.Takegami, N.Tomosugi, S.Miyazawa,
S.Kuwabata: Use of ionic liquid in fungal taxonomic study of ultrastructure of basidiospore ornamentation,
Mycological Prog., 11:343-347, 2012.

Others
7200F001(N.Tahara), S.Yamagishi, A.Tahara, M.Ishibashi, N.Hayabuchi, M.Takeuchi, T.Imaizumi: Adiponectin is inversely
associated with ratio of serum levels of AGEs to sRAGE and vascular inflammation., Int. J. Cardiol., 158:461-462,
2012.

7200F002(T.Suzuki), K.Toba, K.Kato, T.Ozawa, M.Higashimura, T.Kitajima, H.Oda, K.Tsuchida, N.Tomosugi, H.Saitoh,
Y.Aizawa: Serum ferritin levels adversely affect cardiac function in patients with ST-elevation myocardial infarction
who underwent successful percutaneous coronary intervention, Int. J. Cardiol., 167:286-288, 2012.

－ 126 －

Presentations at Conference
International Conference (Presentations)
7200I001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, E.Kubo, H.Sasaki, H.Yonekura: Ultraviolet Binduced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, International
Conference on The Lens, (Hawaii, '12.01).

7200I002(N. Kitaichi), Z. Dong, D. Iwata, M. Takeuchi, K. Namba, K. Noda, A. Kanda, K. Iwabuchi, S. Yamagishi, S. Ohno,
S. Ishida: Amelioration of experimental autoimmune uveoretinitis by inhibiton of toxic AGEs formation., 15th
International Conference on Behcet’s Disease, (Yokohama, '12.07).

7200I003

Y.Ishigaki, Y.Nakamura, T.Takehara, S.Kuwabata, H.Nakagawa, N.Tomosugi, T.Takegami: Ionic liquid enables
simple and rapid sample preparation of human culturing cells for scanning electron microscope (SEM) analysis, 14th
International Congress of Histochemistry and Cytochemistry, (Kyoto, '12.08).

7200I004

J.Yamakawa, Y.Ishigaki, J.Moriya, Y.Motoo, T.Takegami, J.Kobayashi: The Kampo Medicenes Have Diffierent
Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes, 13th International Congress of
the Society for Ethnopharmacology, (Austria, '12.08).

7200I005

J. George, N. Hayashi, M. Takeuchi, M. Tsutsumi: Acetaldehyde-derived advanced glycation end-products
promote alcoholic liver disease., The 7th International Symposium on Alcoholic Liver and Pancreatic Diseases andCirrhosis,, (Beijing, '12.09).

7200I006(Y.Takamura), M.Kita, H.Takabayashi: Microfluidic Approach to Analysis of Nucleated Red Blood Cell for Fetal
DNA Diagnosis from Maternal Blood, FDD-MB WWRC 2012, (Kanazawa, '12.11)，FDD-MB WWRC 2012
Program and Abstracts, 21, 2012.

7200I007(A.Sekizawa), P.Yuditiya, H.Takabayashi, M.Kitagawa: Recent advances in noninvasive prenatal DNA diagnosis
from nucleated erythrocytes in maternal blood, FDD-MB WWRC 2012, (Kanazawa, '12.11)，FDD-MB WWRC
2012 Program and Abstracts, 28, 2012.

7200I008

H.Takabayashi, A.Sekizawa: FDD-MB System, the Present and the Future, INTERNATIONAL JOINTSYMPOSIUM ON SINGLE-CELL ANALYSIS, (Kyoto, '12.11).

－ 127 －

7310

Division of HT Research

Faculty
Title

Name

Field of Specialization

Associate
Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Researcher

ZHANG Jun

Hepatitis C virus

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
7310B001

K.Nakamura, M.Sakurai, M.Nishijo, Y.Morikawa, H.Nakagawa: Characteristics of smoking cessation in former
smokers in a rural area of Japan, Int J Prev Med, 3:459-465, 2012.

7310B002

M.Nishijo, T.Pham-The, H.Nakagawa, S.Maruzeni, T.N.A.Nguyen, V.L.Hoang, H.A.Tran, R.Honda, Y.Morikawa,
T.Kido, H.Nishijo: Impact of perinatal dioxin exposure on infant growth: A cross-sectional and longitudinal studies
in dioxin-contaminated areas in Vietnam, PLoS ONE, 7:e40273, 2012.

7310B003

PT.Tai, M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Loung, TH.Anh, TV.Nhat, TT.Thanh, PT.Phuong,
LTM.Nguyet, LK.Son, Y.Morikawa, T.Kido, H.Nishijo: Dioxin exposure and infant neurodevelopment – a follow up
study in Vietnamese infants, Organohalogen Compounds., 74:1369-1372, 2012.

7310B004

M.Nishijo, PT.Tai, NM.Nui, NTN.Anh, NM.Hai, S.Maruzeni, TN.Nghi, PT.Phoung, H.Nishijo, TH.Anh, HV.Loung,
T.Kido, R.Okamoto, LK.Son, H.Nakagawa: Effects of dioxins exposure on social emotional behavior of children
living in a hot spot area, Vietnam, Organohalogen Compounds., 74:1332-1335, 2012.

7310B005(T.Kido), R.Okamoto, HD.Manh, XL.Sun, NH.Viet, M.Nakano, PT.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, DV.Tung, DD.Nhu, NN.Hung, LK.Son: Dioxin in breast milk of Vietnamese mothers andsteroid hormone in saliva of their infants, Organohalogen Compounds., 74:1361-1364, 2012.

Presentations at Conference
International Conference (Presentations)
7310I001(K.Nogawa), Y.Suwazono, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Change in tubularmarker and calcium excretion after cadmium exposure, 48th Congress of the European-Societies-of-Toxicology(EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

－ 128 －

7310I002(Y.Suwazono), K.Nogawa, T.Kido, M.Nishijo, Y.Morikawa, R.Honda, M.Ishizaki, H.Nakagawa: Biological half-life ofblood cadmium level of inhabitants in cadmium-polluted area, 48th Congress of the European-Societies-ofToxicology (EUROTOX), (Stockholm, SWEDEN, '12.06)，Toxicology Letters, 211:S146, 2012.

7310I003

TT.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, ATN.Nguyen, Loung.HV, Anh.TH, Y.Morikawa, T.Kido, H.Nishijo:
Dioxin exposure and infant neurodevelopment – a follow up study in Vietnamese infants., 32nd International
Symposium on Halogenated Persistent Organic Pollutants;Dioxin 2012, (Cairns, Australia, '12.08)，32nd
International Symposium on Halogenated Persistent Organic Pollutants; Dioxin 2012, 2012.

7310I004

M.Nishijo, Tai.PT, Nui.NM, Anh.NTN, Hai.NM, S.Maruzeni, Nghi.TN, Phoung.PT, H.Nishijo, Anh.TH, Loung.HV,
T.Kido, R.Okamoto, Son.LK, H.Nakagawa: Effects of dioxins exposure on social emotional behavior of children
living in a hot spot area, Vietnam, 32nd International Symposium on Halogenated Persistent Organic Pollutants;
Dioxin 2012, (Cairns, Australia, '12.08).

7310I005(T.Kido), R.Okamoto, Manh.HD, Sun.XL, Viet.NH, M.Nakano, Tai.PT, S.Maruzeni, M.Nishijo, H.Nakagawa,
H.Suzuki, S.Honma, Tung.DV, Nhu.DD, Hung.NN, Son.LK: Dioxin in breast milk of Vietnamese mothers andsteroid hormone in saliva of their infants., 32nd International Symposium on Halogenated Persistent Organic
Pollutants; Dioxin 2012, (Cairns, Australia, '12.08).

－ 129 －

7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Senior AssistantProfessor(Additional Post)

KAWAKAMI Yutaka

cataract, thyroid ocular

Researcher

HASANOVA Nailia

cataract,electromagnetic ocular injury

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, "glaucoma, age related maculardegeneration", "JICA, WHO, outdoor temperature, risk factors search", "Reykjavik eye study, Monzen eye study","Liaoning eye study, racial differences"

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
7320B001

M.Fukuda, H.Sasaki: Quantitative evaluation of corneal epithelial injury caused by n-heptanol using a corneal
resistance measuring device in vivo, Clin. Ophthalmol., 6:585-593, 2012.

7320B002

K.Hagiwara, K.Kitagawa, H.Sasaki: Two cases of varicella keratitis requiting long-term treatment for cure, Journalof the eye., 29:549-553, 2012 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
7320I001

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, E.Kubo, Y.Sakamoto, K.Sasaki, D.Beebe, F.Bai, Y.B.Shui: Anatomic
risk factors for age-related cataract in a rural japanese population, International Conference on The Lens, (Hawaii,'12.01).

－ 130 －

7320I002

E.Kubo, N.Hasanova, H.Sasaki, N.Fatma, D.P.Singh: Sulforaphanc mobilizes cellular antioxidant defenses that
protect lens epithelial cells against damage by UV radiation, International Conference on The Lens, (Hawaii,'12.01).

7320I003(N.Fujii), K.Kawaguchi, H.Sasaki, N.Fujii: Simultaneous isomerization at the asp-4 residue in βB2-crystallin fromthe ager human eye lenses, International Conference on The Lens, (Hawaii, '12.01).

7320I004

M.Kojima, K.Sasaki, H.Sasaki: Pathogenic mechanism of heat cataract induced by infrared rays and electric wave
exposure, International Conference on The Lens, (Hawaii, '12.01).

7320I005

N.Hatsusaka, E.Shibuya, N.Mita, H.Osada, N.Shibata, S.Shibata, N.Fujita, H.Yaguchi, E.Kubo, K.Sasaki,
H.Sasaki: Influence of watr clefts and cofts and cortical cataract on refraction in human eye, International
Conference on The Lens, (Hawaii, '12.01).

7320I006

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, E.Kubo, H.Sasaki, H.Yonekura: Ultraviolet Binduced expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, International
Conference on The Lens, (Hawaii, '12.01).

7320I007

M.Kojima, N.Hasanova, Y.Suzuki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Ocular Temperature Measurement duringg 40GHz Exposure to Rabbit, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

7320I008(Y.Susuki), A.Koike, M.Kojima, K.Sasaki, K.Wake, N.Hasanova, M.Taki, S.Watanabe, K.Sasaki, H.Sasaki:
Computational and experimental dosimetry for rabbit eyes exposed to millimeter waves, 2012 Korea-Japan
EMT/TEMC/BE Joint Conference, (Korea, '12.04).

7320I009(K.Nagai), N.Mita, N.Hatsusaka, R.Honda, H.Osada, E.Kubo, H.Sasaki, K.Sasaki: Factors influencing retinal image
contrast in eyes with retrodots (Reykjavik Eye Study), The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

7320I010

H.Osada, S.Shibata, R.Honda, N.Hatsusaka, M.Takahashi, M.Sasaki, Y.Hirata, N.Shibata, E.Kubo, H.Sasaki:
Pinguicula in urban office workers in Japan, The Association for Research in Vislon and Ophthalmology, (Florida,'12.05).

7320I011

M.Fukuda, S.Shibata, N.Shibata, H.Osada, K.Hagiwara, H.Yaguchi, E.Kubo, H.Sasaki: Influence of antiglaucoma
fixed combination drugs to the cornea and aqueous humor concentration of timjolol maleate in rabbits, The
Association for Research in Vislon and Ophthalmology, (Florida, '12.05).

7320I012

M.Kojima, H.Sasaki, K.Sasaki, N.Hasanova, Y.Suzuki, M.Taki, K.Sasaki, K.Waki, S.Watanabe: Study of acuteocular damage threshold of 40 GHz millimeter wave, The Association for Research in Vislon and Ophthalmology,(Florida, '12.05).

7320I013

H.Sasaki, N.Hatsusaka, E.Shibuya, N.Mita, A.Okamoto, H.Osada, M.Kojima, E.Kubo, K.Sasaki: 12-year change ofcrystalline lens power by opacity type Reykjavik Eye Study, The Association for Research in Vislon andOphthalmology, (Florida, '12.05).

7320I014

N.Hatsusaka, Y.Suzuya, T.Kawahara, H.Sasaki: Relationship between reading performance of the elderly and eye
movemants, The Association for Research in Vislon and Ophthalmology, (Floroda, '12.05).

7320I015

E.Kubo, N.Hasanova, H.Sasaki, B.Chhunchha, N.Fatma, D.P.Singh: Sulforaphane mobilizes cellular antioxidant
defenses that protect lens epithelial cells against damage by UV radiation and delays rat cataract, The Association
for Research in Vislon and Ophthalmology, (Florida, '12.05).

7320I016

E.Kubo, N.Hasanova, H.Sasaki, N.Fatma, D.P.Singh: Peroxoredpxon 6 and its induction by sulforaphane
upregulates cellular antioxidant defense signaling and prevention of cataract in rat lens, XX Biennial Meeting of theinternational society for eye research, (Berlin, '12.07).

7320I017

H.Sasaki, N.Hatsusaka, E.Shibuya, H.Osada, E.Kubo, K.Sasaki, F.Jonasson: Types of caratact and change ofcrystalline lens power and refractive power -reykjavik Eye Study-, XXX Congress of the ESCRS, (Milano, Italy,'12.09).

7320I018

M.Kojima, N.Hasanova, Y.Suauki, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Investigation of ocular temperature change in rabbits during 40 HGz band exposure, EMC EUROPE
2012, (Rome, '12.09).
－ 131 －

7320I019

M.Kojima, N.Hasanova, Y.Suauki, K.Wake, K.Sasaki, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: In vestigation of acute ocular damagc threshold of 40 GHz millimeter wave on rabbit, 37th IRMMW-THz
2012, (Korea, '12.09).

7320I020(T.Okuno), M.Kojima, N.Hasanova, Y.Ishiba, Y.Suzuki, D.HSliney: Injury thresholds for IR-A laser exposure in the
rabbit lens, Asian pacific association of laser medicine & surgery, (Taiwan, '12.11).

－ 132 －

7330

Division of Dermatomycology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Assistant
Professor(Additional Post)

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Publications
Originals
7330B001

K.Takeda, A.Nishibu, K.Anzawa, T.Mochizuki: Molecular epidemiology of a major subgroup of Arthroderma
benhamiae isolated in Japan by restriction ｆragment ｌength polymorphism analysis of the non-transcribed spacer
region of ribosomal RNA gene, Jpn.J.Infect.Dis., 65:233-239, 2012.

7330B002

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki: New strain typing method with Sporothrix schenckii using
mitochondrial DNA and polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)
technique, J. Dermatol., 39:362-365, 2012.

7330B003(R.Kano), M.Kawasaki, T.Mochizuki, M.Hiruma, A.Hasegawa: Mating genes of the Trichophyton mentagrophytes
complex, Mycopathologia, 173:103-112, 2012.

7330B004(T.Nakamura), A.Nishibu, M.Yasoshima, C.Tanoue, N.Yoshida, J.Hatta, T. Miyamoto, M.Nishii, T.Yanagibashi,
Y.Nagai, K.Takatsu, T.Mochizuki, K.Ogawa: Analysis of Trichophyton antigen-induced contact hypersensitivity inmouse, J. Dermatol. Sci., 66:144-153, 2012.

7330B005(M.Hiruma), R.Kano, T.Sugita, T.Mochizuki, A.Hasegawa, M.Himura: Epidemiological aspects of Trichophyton

rubrum var. raubitschekii in Japan, J. Dermatol., 39:1000-1001, 2012.
7330B006

T.Sakamoto, K.Anzawa, T.Fujii, H.Tanabe, T.Mochizuki, T.Toyomoto: An outbreak of Trichophyton tonsurans
infection and its surveillance in a women's university judo team, Skin research, 11:313-318, 2012 (in Japanese) .

Case Reports－ 133 －

7330D001

T.Mochizuki, H.Kobayashi, K.Takeda, K.Anzawa, H.Ishizaki: The first human cases of Americano-European raceof Arthroderma benhamiae infection in Japan, Jpn. J. Infect. Dis., 65:558-559, 2012.

7330D002(K.Tamura), T.Matsuyama, E.Yahagi, T.Kojima, E.Akasaka, A.Kondo, N.Ikoma, T.Mabuchi, S.Tamiya, A.Ozawa,T.Mochizuki: A case of chromomycosis treated by surgical therapy combined with preceded oral administration of
terbinafine to reduce the size of the lesion, Tokai J. Exp. Clin. Med., 37:6-10, 2012.

7330D003

T.Mochizuki, M.Kawasaki, K.Anzawa, K.Kojima, J.Hatta, H.Tanabe, S.Higaki, S.Fujita: Extra-scalp black dot
ringworm caused by Trichophyton tonsurans among contact sports players, Mycopathologia, 173:241-244, 2012.

Others
7330F001(M.Tochigi), T.Ochiai, C.Mekata, H.Nishiyama, K.Anzawa, M.Kawasaki: Sporotrichosis of the face by
autoinoculation in a patient undergoing tacrolimus treatment, J. Dermatol., 39:796-798, 2012.

Presentations at Conference
International Conference (Synposium)
7330H001

T.Mochizuki: Outbreaks of community-acquired and nosocomial dermatophytoses in Japan, The 18 th Congress ofInternational Society of Medical and Veterinary Mycology, (Berlin, Germany, '12.06).

International Conference (Presentations)
7330I001

K.Kojima, K.Niida, A.Nishibu, T.Mochizuki: A case of hereditary angioedema type 1 with blisters, The 2nd
Eastern Asia Dermatology Congress, (Beijin, '12.06).

7330I002

M.Kawasaki, K.Anzawa, T.Mochizuki: Is Trichophyton interdigitale a valid species?, The 18th Congress ofInternational Society of Medical and Veterinary Mycology, (Berlin, Germany, '12.06).

－ 134 －

Aff ilate d I n s t i t u t i o n

9050

Center for FDD-MB

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Researcher

YUDITIYA Purwosunu fetal medicine, DNA medicine

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's
health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology

Presentations at Conference
International Conference (Presentations)
9050I001(Y.Takamura), M.Kita, H.Takabayashi: Microfluidic Approach to Analysis of Nucleated Red Blood Cell for Fetal
DNA Diagnosis from Maternal Blood, FDD-MB WWRC 2012, (Kanazawa, '12.11)，FDD-MB WWRC 2012
Program and Abstracts, 21, 2012.

9050I002(A.Sekizawa), P.Yuditiya, H.Takabayashi, M.Kitagawa: Recent advances in noninvasive prenatal DNA diagnosis
from nucleated erythrocytes in maternal blood, FDD-MB WWRC 2012, (Kanazawa, '12.11)，FDD-MB WWRC
2012 Program and Abstracts, 28, 2012.

9050I003

H.Takabayashi, A.Sekizawa: FDD-MB System, the Present and the Future, INTERNATIONAL JOINTSYMPOSIUM ON SINGLE-CELL ANALYSIS, (Kyoto, '12.11).

－ 135 －

9030

Northerm Noto Institute for Community Medicine

Faculty
Title

Name

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Assistant
KITAMURA Kenji
Professor(Additional Post)
Research Doctor(Additional
AKAGAWA Makoto
Post)

Field of Specialization

Hip surgery
orthopaedic surgery

Keywords of Research
The Elderly, Rural Medicine, Medical Needs

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

Publications
Originals
9030B001

S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi,
H.Toga: Sleep apnoea syndrome as a risk for mortality in elderly inpatients, J. Int. Med. Res., 40:601-611, 2012.

－ 136 －

H im i M u n i c i p a l H o s p i t a l

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery

Professor

FUKUDA Akihiro

Cardiology

Professor

IZUMI Youichi

Hypertension, Endocrinology

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Professor

MATSUKI Nobuo

Oncology Surgery

Associate Professor

URASHIMA Sachio

Gastroenterology

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

YOSHITANI Shinichiro Oncology Surgery

Associate Professor

IKEBUCHI Kimihiro

Orthopaedic Surgery

Associate Professor

KUZAWA Yutaka

Cardio Vascular Surgery

Associate Professor

URATA Kazuhiko

Obstetrics and gynecology

Associate Professor

TAKADA Hisashi

Neurosurgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

ASANO Masamitsu

Cardiology

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

KIYOSAWA Jun

Vascular Surgery

Senior Assistant Professor

AOKI Nobuyuki

Orthopaedic Surgery

Senior Assistant Professor

WATANABE Seiji

Bacteriology

Senior Assistant Professor

TSUCHIDA Maki

Ophthalmology

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

FUJIKI Takuma

Pediatrics

Assistant Professor

MIZUNO Takuro

regional medicine

Assistant Professor

ASTUMI Hisanari

Endocrinology

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

USUDA Daisuke

General Medicine

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

ARISAWA Akiko

Orthopaedic Surgery

Assistant Professor

KUSABA Eizo

Neurosurgery

Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies－ 137 －

Publications
Originals
9100B001

K.Ishigami, M.Okuro, Y.Koizumi, K.Satoh, O.Iritani, H.Yano, T.Higashikawa, K.Iwai, S.Morimoto: Association ofsevere hypertension with pneumonia in elderly patients with acute ischemic stroke, Hypertens. Res., 35:648-653,
2012.

9100B002

S.Morimoto, T.Takahashi, K.Okaishi, M.Okuro, T.Nakahashi, D.Sakamoto, T.Mizuno, T.Kanda, M.Takahashi,
H.Toga: Sleep apnoea syndrome as a risk for mortality in elderly inpatients, J. Int. Med. Res., 40:601-611, 2012.

9100B003

Y.Sasagawa, O.Tachibana, S.Shiraga, H.Takata, T.Akai, H.Iizuka: A clincal feature and therapeutic strategy in
pituitary adenomas associated with intracranial aneurysms, Neurological surgery., 40:15-21, 2012 (in Japanese) .

－ 138 －