I
Code

Department

N
Page

Liberal Arts

D

E
Code

X
Department

Page

0240 Department of Epidemiology and Public Health ･･･33

0010

Department of Human Science (Humanities) ･･･1

0250

Department of Legal Medicine ･･･････････････37

0030

Department of Human Science (Mathematics) ･･2

0260

Department of Medical Education ････････････38

0040

Department of Life Science(Natural Science:Physics)

Clinical Medicine････････････････････3

Department of Life Science

0300

Department of Cardiovascular Medicine ･･･････39(Natural Science:Chemistry) ･･････････････････40310

Department of Respirolgy (Respiratory Medicine)･･41

Department of Life Science

0320

Department of Gastroenterology ･････････････43(Natural Science:Biology) ･････････････････････50330

Department of Nephrology ････････････････････45

Department of Human Science

0340

Department of Endocrinology and Metabolism･･･47(Foreign Languages:English) ･･････････････････60350

Department of Hematology and Immunology ･･･50

Department of Human Science

0360

Department of Neurology ･････････････････････53(Foreign Languages:German) ･･････････････････70370

Department of Geriatric Medicine･･････････････55

0081 Department of Human Science (Linguistics) ･･････80380

Department of Pediatrics ･････････････････････57

0090 Department of Life Science (Physical Education) ･･･90390

Department of Neuropsychiatry ･･･････････････59

0400

Department of Diagnostic and Therapeutic

0050

0060

0070

0080

Radiology ･･･････････････････････････････････61

School of Medicine
0410

Department of Cardiovascular Surgery ･･････63

Department of Molecular and Cell Structural

0420

Department of Surgical Oncology ････････････65

Science (Anatomy Ⅰ) ･･･････････････････････110430

Department of Orthopedics Surgery ･･･････････66

Department of Molecular and Cell Structural

0440

Department of Neurosurgery ･････････････････68

Science (Anatomy Ⅱ) ････････････････････････130450

Department of Plastic and Reconstructive

Basic
0100

0110

0120

Medicine

Surgery ････････････････････････････････････70

Department of Physiology Ⅰ･･････････････････14

0130 Department of Physiology Ⅱ ･･････････････････160460

Department of Pediatric Surgery ･･････････････72

0140

Department of Biochemistry Ⅰ･･･････････････18

0470

Department of Ophthalmology ････････････････74

0150

Department of Biochemistry Ⅱ ･･････････････20

0480

Department of Otolaryngology ････････････････77

0160

Department of Pharmacology ････････････････21

0490

Department of Dermatology･･･････････････････79

0170

Department of Oncologic Pathology ･･････････220500

Department of Urogenital Surgery ････････････81

0180

Department of Pathophysiological and0510

Department of Obstetrics and Gynecology ･････83

Experimental Pathology ････････････････････240520

Department of Anesthesiology andPerioperative Medicine ･･････････････････････85

0190

Department of Microbiology ･････････････････26

0200

Department of Fundamental Research for CAM ･･27

0530

Department of Oral and Maxillofacial Surgery･･87

0210

Department of Medical Zoology･･･････････････28

0550

Department of Emergency Medicine････････････89

0220

Department of Pathology and Laboratory

0560

Department of Medical Oncology ･･････････････90

Medicine ･･･････････････････････････････････29

0570

District medical ･･････････････････････････････91

Department of Social and Environmental

0610

Health Management Center･･････････････････93

Medicine ･･･････････････････････････････････31

0620

Department of Pathology ･････････････････････97

0230

Code

Department

0630

Department of General Internal Medicine ･･････98

0640

Endoscopy Center ･･･････････････････････････100

0650

Department of Rehabilitation Medicine ･･･････101

0660

Department of Respirology (Thoracic Surgery) ･･102

0670

Lifestyle-related Diseases Center ････････････104

0680

Medical Genetic Center･･････････････････････105

0690

Department of Endoscopy････････････････････106

0700

Multidiscciplinary Cancer Center･････････････107

Schoolof

Nursing

8010

Basic Nursing ･････････････････････････････109

8030

Psychiatric and Mental Health Nursing･･･････110

8040

Adult Nursing

8050

Nursing of the Elderly ･･････････････････････112

8060

Child Nursing ･･････････････････････････････113

8070

Maternity Nursing ･････････････････････････114

8080

Community Nursing･････････････････････115

8090

Home Care Nursing･･･････････････････････116

8100

Human Science

MedicalResearchPage････････････････････････････111････････････････････････117

Institute/ Center for FDD-MB

0710

Medical Research Institute･･･････････････････121

0740

Division of Human Genetics (Biochemistry) ･･122

0750

Division of Human Genetics (Clinical Medicine) ･123

0770

Division of Core Facility (Radioisotope Center) ･･124

0780

Division of Core Facility(Experimental Animal Center) ･･････････････126

0790

Division of Core Facility(Morphological Equipment Center) ･･････････127

0800

Division of Core Facility(High-Tech Research Center) ･･･････････････128

0900

Division of Cell Medicine ･･･････････････････130

0910

Division of Advanced Medicine ･･････････････131

0920

Division of Molecular Oncology and Virology ････133

0930

Division of Dermatomycology(Novartis Pharma) ･････････････････････････135

0970

Division of Vision Research forEnvironmental Health ･･････････････････････137

Code

9050

Department

Center for FDD-MB･･････････････････････････140

Himi Municipal Hospital
9100

Himi Municipal Hospital･････････････････････141

Page

Ｌｉｂｅｒａｌ Ａｒｔｓ

0010Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

HIRAGUCHI Tetsuo

environmental-ethnoarchaeology， peace studies．

TAKEDA Koichi

Philosophy , History of logic

Keywords of Researchzoo-archaeology, cetacean, dolphin, whale, faunal remains, environmental archaeology, whaling, ancient diet, Palaeolithic
period, Jomon period, ethno-archaeology, anthropological education, peace study, logic, metaphysics, form, content,
predicate, category, deduction, induction, matter, being, substance, definion

Outline of Research
Hiraguchi:Environmental and ethnological archaeology (especially prehistoric whaling), anthropological education for medical
students, and peace studies.
Takeda:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

－ 1 －

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field

－ 2 －

0040

Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Keywords of Researchpiriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording

Outline of Research
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: In order that the student who majors in life science may deepen an understanding of a lecture, and in order toenable independent learning, we are developing the stude support which used a demonstration experiment and intranet.

－ 3 －

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

Publications
Originals
0050B001

M.Maeda, M.Murakami, T.Takegami, T.Ota: Promotion or suppression of experimental metastasis of B16 melanoma
cells, Toxicol. Appl. Pharmacol., 229:232-238, 2008.

Presentations at Conference
International Conference (Presentations)
0050I001

T.Ota, M.Maeda, Z.-P.Zong, M.Murakami, T.Takegami, M.Tatsuka: Phosphorylation and localization of FAK in vSrc transformed fibroblast cells after anoikis induction., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

0050I002

Z.-P.Zong, M.Maeda, M.Murakami, T.Takegami, M.Tatsuka, T.Ota: Effects of oral administration of lapachol on
experimental metastasis of B16 melanoma cells in mice., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

－ 4 －

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

HORI Isao

Development of ascidians

ASAI Etsuo

Regeneration of planarians

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell

Outline of Research
It is well known that planarians have a strong power of regeneration. This power depends mainly on a large number ofundifferentiated stem cells or neoblasts which distribute through the parenchymal region of intact planarians. I have studied
differentiation,proliferation and morphogenesis of these neoblasts by using an electron microscope. Neoblasts are small insize and oval in shape. Their cytoplasm is occupied with free ribosomes and mitochondria. Synthetic organelles are notdeveloped. Most characteristic feature is several chromatoid bodies surrounding the nuclear envelope.
Their size and number reduce during cell differentiation. Formation of the chromatoid bodies is inhibited by actinomycin D.
These results suggest that chromatoid bodies relate to differentiation of neoblasts. I also studied the process ofmorphogenesis of muscle layers, gastrodermis and epidermis after decapitation. The data suggest that a kind of
neuropeptides and retinoic acid stimulate cell differentiation within the regeneration blastema.

Publications
Originals
0060B001(K.Wakabayashi), M.Komatsu, M.Murakami, I.Hori, T.Takegami: Morphology and gene analysis of hybrids between
two congeneric sea stars with dfferent modes of development, Biol. Bull., 215:89-97, 2008.

0060B002(S.Amano), I.Hori: Hemocyte diffenetiation in the juveniles of the ascidian Halocynthia roretzi., Invertebr. Reprod.
Dev., 51:11-18, 2008.

－ 5 －

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

SHIBUYA Yoshiho

English linguistics，Phonetics

KAKIZAKI KenichiContemporary Jewish American Authors' WorksCURRY Carla

English education from a viewpoint of music

BURKE STEVEN
ThomasEnglishKeywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, Performance studies, chanting, oral interpretation,
Musicology

Outline of Research
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
C.Curry: I am also interested in how to teach phonics to students who do not use a language represented by a phonetic
alphabet. Therefore, I have been studying the various techniques for teaching English phonics to young learners in Japan.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.

Publications
Originals
0070B001

K.Kakizaki: The rediscovery of jewish heritage in “The Old System”, Shlemiel., ７:21-34, 2008.

0070B002

K.Kakizaki: The narcissistic collapse of the self in dangling man, The Journal of Psychoanalytical Study of English
Language and Literature., 28:53-67, 2008.

0070B003

K.Kakizaki: The holocaust and memory in the bellarosa connection, Journal of English Language and Literature,
56:43-58, 2008.

0070B004

K.Kakizaki: Spiritual awakening in “Dora”, Mem. Lib. Kanazawa Med. Univ., 36:39-47, 2008.

－ 6 －

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

HARA Akira

Austria literature led by Hofmannsthal

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

－ 7 －

0081

Department of Human Science (Linguistics)

Faculty
Title

Name

Field of Specialization

AINODA Noriko

How do the Japanese medical students acquire medical terms in
English as a second language? My research focuses on this question
using both linguistic and phonetic knowledge, with the research
evidence in cognitive science.

Keywords of Research
English education, medical English, learning

Outline of Research
Metacognition is an essential factor for lifelong learning of which skills should be fostered during undergraduate medical
education. To seek longitudinal changes in metacognitive processes through problem-based learning (PBL), the year 3
students' reflective comments were categorically analized. The results showed that "knowledge of ignorance," one ofmetacognitive skills, could be fostered in PBL.

－ 8 －

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

YAMASHINA Tadahiko
UEDA Fumio

Muscle Strength, Muscle Strength Training, Thickness of Muscles inthe Lower leg
Physical strength and a study about the athletic capability，Abasketball competition

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Yamashina : To find an effective way to prevent falling ,I have studied the ability to sustain a standing posture and fallingmechanism.
To clarify the association between antigravity muscles and the ability to sustain static and active standing posture.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.

Publications
Originals
0090B001

N.Tamura: Report on the use of wheelchairs among Kanazawa Medical University 1st-year students, Mem. Lib.
Kanazawa Med. Univ., 36:49-56, 2008 (in Japanese) .

0090B002

T.Yamashina: The interrelation of the crural muscle group with human walking and equilibriun function, Mem. Lib.
Kanazawa Med. Univ., 36:57-64, 2008 (in Japanese) .

0090B003

F.Ueda, N.Tamura, T.Yamashina: A report on the pysical fitness and motor ability of students at Kanazawa
Medical University (ⅩⅩⅩⅣ), Mem. Lib. Kanazawa Med. Univ., 36:65-72, 2008 (in Japanese) .

－ 9 －－ 10 －

Ｓｃｈｏｏｌ ｏｆ Ｍｅｄｉｃｉｎｅ

0100Department of Molecular and Cell Structural Science (Anatomy Ⅰ)

Faculty
Title

Name

Field of Specialization

HATTA Toshihisa

developmental biology, neuroscience

HIGASHI Nobuaki

macroscopic anatomy,embryology.

SHIMADA Hiroki

Medical science of free radical

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

H.Otani, J.Udagawa, T. Lundh, T.Hatta, R.Hashimato, A.Masumoto, F.Satow: Morphometric study on thecharacteristic external features of normal and abnormal human embryos, Congenit. Anom. (Kyoto), 48:18-28,
2008.

0100B002

E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai: Bioreductive activation of quinone antitumor
drugs by mitochondrial voltage-dependent anion channel 1, Anat. Sci. Int., 83:261-266, 2008.

Reviews
0100C001

E.Simamura, H.Shimada, T.Hatta, K-I.Hirai: Mitochondrial voltage-dependent anion channels (VDACs) as novel
pharmacological targets for anti-cancer agents, J. Bioenerg. Biomembr., 40:213-217, 2008.

0100C002

K.Kaneyama, N.Segami, T.Hatta: Congenital deformities and developmental abnormalities of the mandibular
condyle in the temporomandibular joint, Congenit. Anom. (Kyoto), 48:118-125, 2008.

Case Reports
0100D001

N.Higashi, H.Shimada, E.Simamura, T.Hatta: Right vertebral artery as the fourth branch of the aortic arch, Anat.
Sci. Int., 83:314-318, 2008.

－ 11 －

Short Communications
0100E001(M.Yamada), T.Hatta, H.Otani: Mouse exo utero development system: Protocol and troubleshooting, Congenit.
Anom. (Kyoto), 48:183-187, 2008.

－ 12 －

0110

Department of Molecular and Cell Structural Science (Anatomy Ⅱ)

Faculty
Title

Name

Field of Specialization

SHINOHARA
Harumichi

gross anatomy,embryology,lymphatic vessels,microscopy.

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve.
YASUTAKA Satoru

gross anatomy,central nervous system.

KOMINAMI Rieko

immunocytochemistry,pituitary,cell proliferation,electron microscopy.

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

Publications
Originals
0110B001

T.Shimokawa, S.Yasutaka, R.Kominami, S.Tanaka, H.Shinohara: Pitx1 expression in developing and regenerating
axolotl limbs, Okajimas Folia Anat Jpn, 85:5-10, 2008.

0110B002(H.Ming-Yu), T.Shimokawa, R.Kominami, S.Yasutaka, H.Shinohara: Morphological characteristics of the branchial
nerve in axolotl embryos at different stages (in Chinese ), Chinese journal of zoology, 43:121-125, 2008.

Short Communications
0110E001(H.Ming-Yu), T.Shimokawa, R.Kominami, S.Yasutaka, H.Shinohara: Developmental study of hypoglossal nerve inaxolotl embryo (in Chinese), Chinese journal of anatomy, 31:862-863, 2008.

－ 13 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

KATO Nobuo

Brain Science

SUGAI Tokio

Neurophysiology

YAMAMOTO Ryo

Neuroscience

ADACHI Hiroshi

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001

H.Yoshimura, M.Honjo, Y.Mashiyama, K.kaneyama, N.Segami, J.Sato, T.Sugai, N.kato, N.Onoda: Multiple toothlosses during development suppress age-dependent emergence of oscillatory neural activities in the oral
somatosensory cortex., Brain Res., 1224:37-42, 2008.

0120B002

Y.Ueta, R.Yamamoto, S.Sugiura, K.Inokuchi, N.Kato: Homer 1a suppresses neocortex long-term depression in a
cortical layer-specific manner., J. Neurophysiol., 99:950-957, 2008.

Others
0120F001

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Functional connections between olfactory and gustatory information
via the endopiriform nucleus in the rat., The Japanese journal of taste and smell research., 15:345-346, 2008 (inJapanese) .

－ 14 －

Presentations at Conference
International Conference (Presentations)
0120I001

N.Kato, Y.Ueta, K.Yamamoto, R.Yamamoto, T.Sugai: The cortical layer specificity in physiolgical effects ofelectroconvulsive therapy in a rat model., A Brain Research Meeting: Stress, Coping and Disease., (Washington
DC, '08.11).

0120I002

K.Yamamoto, Y.Ueta, R.Yamamoto, N.Kato: Intracellular amyloid-βenhances spike-induced calcium increase by
suppressing BK channels in neocortical pyramidal neurons., Neuroscience 2008, (Washington DC, '08.11).

－ 15 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

SHIBAMOTO
Toshishige

Circulatory Physiology

KURATA Yasutaka

Cardiac Electrophysiology

MIYAMAE Shunichi

Cardiac Electrophysiology

KAMIKADO Chiaki

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

S.Cui, T.Shibamoto, W.Zhang, H.Takano, Y.Kurata: Venous resistance increases during rat anaphylactic shock.,
Shock, 29:733-739, 2008.

0130B002(Y.Hirota), Y.Kurata, M.Kato, T.Notsu, S.Koshida, T.Inoue, Y.Kawata, J.Miake, U.Bahrudin, P.Li, Y.Hoshikawa,
Y.Yamamoto, O.Igawa, Y.Shirayoshi, A.Nakai, H.Ninomiya, K.Higaki, M.Hiraoka, I.Hisatome: Functional
stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines., Biochem. Biophys. Res. Commun., 372:469-474,
2008.

0130B003

Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto: Regional difference in dynamical property of sinoatrial node
pacemaking: role of Na+ channel current., Biophys. J., 95:951-977, 2008.

0130B004

T.Shibamoto, C.Kamikado, S.Koyama: Increased sinusoidal resistance is responsible for the basal state andendothelin-induced venoconstriction in perfused cirrhotic rat liver, Pflugers Arch., 456:467-477, 2008.

0130B005

T.Shibamoto, W.Liu, S.Cui, W.Zhang, H.Takano, Y.Kurata: PAF, rather than histamine, participates in mouse
anaphylactic hypotension., Pharmacology., 82:114-120, 2008.

－ 16 －

0130B006(S.Yano), J.Miake, E.Mizuta, K.Manabe, U.Bahrudin, K.Morikawa, K.Arakawa, N.Sasaki, O.Igawa, C.Shigemasa,
Y.Yamamoto, T.Morisaki, K.Hidaka, Y.Kurata, A.Yoshida, G.Shiota, K.Higaki, H.Ninomiya, JK.Lee, Y.Shirayoshi,
I.Hisatome: Changes of HCN gene expression and If currents in Nkx2.5-positive cardiomyocytes derived frommurine embryonic stem cells during differentiation., Biomed. Res., 29:195-203, 2008.

Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, S.Cui, W.Zhang, Y.Kurata: Vascular resistance to venous return increases during rat anaphylactic
shock., International Shock Congress 2008, (Cologne (Germany), '08.07)，Shock, 29 (Suppl 1):67, 2008.

－ 17 －

0140

Department of Biochemistry Ⅰ

Name

Field of Specialization

Faculty
Title

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins
MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

HASHIMOTO
Mitsumasa

Cell biology, DNA repair, Cell cycle, p53-binding proteins

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

K.Iwabuchi, M.Hashimoto, T.Matsui, A.Kurosawa, N.Adachi, T.Date: Cell sorting analysis of cell cycle-dependent
X-ray sensitivity in end joining-deficient human cells, Biochem. Biophys. Res. Commun., 372:662-667, 2008.

0140B002

K.Iwabuchi, T.Matsui, M.Hashimoto, Y.Matsumoto, T.Kurihara, T.Date: Characterization of a cancer cell line that
expresses a splicing variant form of 53BP1:Separation of checkpoint and repair functions in 53BP1, Biochem.
Biophys. Res. Commun., 376:509-513, 2008.

0140B003

M.Hashimoto, T.Matsui, K.Iwabuchi, T.Date: PKU-β/TLK1 regulates myosin Ⅱ activities, and is required for
accurate equaled chromosome segregation, Mutat. Res., 657:63-67, 2008.

Reviews
0140C001(J.Kobayashi), K.Iwabuchi, K.Miyagawa, E.Sonoda, K.Suzuki, M.Takata, H.Tauchi: Current topics in DNA doublestrand break repair, J. Radiat. Res., 49:93-103, 2008.

Presentations at Conference
International Conference (Presentations)
0140I001

K.Iwabuchi, M.Hashimoto, T.Matsui, T.Date: Indentification of a cancer cell-line that expresses a splicing variant
form of 53BP1:separation of checkpoint and repair functions in 53BP1, The International Ataxia-Telangiectasia
Workshop2008, (Otsu, '08.04)，Ataxia-Telangiectasia Workshop2008 Abstracts, 141, 2008.

－ 18 －

0140I002

T.Date, M.Hashimoto, T.Matsui, M.Ozaki, K.Iwabuchi: PKU-beta/TLK1 plays a dual role in both centrosome
separation and chromosome segregation, 33th FEBS Congress 11th IUBMB Conference, (Athens, '08.06)，
Abstracts, 112, 2008.

－ 19 －

0150

Department of Biochemistry Ⅱ

Name

Field of Specialization

Faculty
Title

Molecular mechanisms of angiogenesis, Alternative ｍRNA
processing, MicroRNA function
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein
YONEKURA Hideto(Additional Post)

NAGAO Yosinobu

Spermatogenesis and epigenetics

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001(S.Matsumoto), T.Yoshida, H.Murata, S.Harada, N.Fujita, S.Nakamura, Y.Yamamoto, T.Watanabe, H.Yonekura,
H.Yamamoto, T.Ohkubo, Y.Kobayashi: Solution structure of the variable-type domain of the receptor for advanced
glycation end products:new insight into AGE-RAGE interaction, Biochemistry, 47:12299-12311, 2008.

Presentations at Conference
International Conference (Presentations)
0150I001

H.Yonekura, N.Turuoka, Y.Yoshitake, L.Sun, T.Watanabe, H.Yamamoto: Regulatory mechanisms of alternative 3'end processing of soluble VEGF receptor pre-mRNA in vascular endothelial cells, 33rd FEBS Congress & 11th
IUBMB Conference, (athens, '08.06)，the FEBS Journal, 275:134, 2008.

0150I002

Y.Yoshitake, H.Yonekura: Ｍｉｃｒｏ-RNAs ｅｘｐｒｅｓｓｅｄ ｉｎ ｈｕｍａｎ microvascular endothelial cells, 33rd FEBS
Congress & 11th IUBMB Conference, (athens, '08.06)，the FEBS Journal, 275:155, 2008.

－ 20 －

0160

Department of Pharmacology

Faculty
Title

Name
NISHIO Matomo(Additional Post)

ISHIBASHI Takaharu
YOSHIDA Junko

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemPharmacology in cardiovascular system, Cancer chemotherapy

Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular system, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
NAKAMOTO Mihoko
compounds in cardiovascular system, Cancer chemotherapy

NISHIZAWA Naoki

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, photolysis, excitable membrane, cardiovascular system,
ischemic disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary
circulation, nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor
drug, proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

T.Ishibashi, T.Miwa, I.Shinkawa, N.Nishizawa, M.Nomura, J.Yoshida, M.Nishio: Quantifying nanomolar levels of
nitrite in biological samples by HPLC-Griess method: Special reference to arterio-venous difference in vivo,
Tohoku J. Exp. Med., 215:1-11, 2008.

0160B002

J.Yamakawa, Y.Ishigaki, F.Takano, T.Takahashi, J.Yoshida, J.Moriya, T.Takata, T.Tatsuno, K.Sasaki, T.Ohta,
T.Takegami, F.Yoshizaki: The kampo medicines orengedokuto, bofutsushosan and boiogito have different activities
to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles,
Biol.Pharm.Bull., 31:2083-2089, 2008.

－ 21 －

0170

Department of Oncologic Pathology

Faculty
Title(Additional Post)

Name

Field of Specialization

TANAKA Takuji

Inhibition of carcinogenesis, Oncologic pathology of digestive organ,
Experimental pathology

SUGIE Shigeyuki

Experimental pathology, Oncologic pathology of digestive organ

KOHNO Hiroyuki

Experimental pathology,Tumor immunology

YASUI Yumiko

Lipids in carcinogenesis

OYAMA Takeru

Mechanisms of carcinogenesis

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Publications
Originals
0170B001(S.Miyamoto), Y.Yasui, M.Kim, S.Sugie, A.Murakami, R.Ishigamori-Suzuki, T.Tanaka: A novel rasH2 mouse
carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is usefulfor preclinical chemoprevention studies, Carcinogenesis, 29:418-426, 2008.

0170B002(S.Miyamoto), Y.Yasui, T.Tanaka, H.Ohigashi, A.Murakami: Suppressive effects of nobiletin on hyperleptinemia
and colitis-ralted colon carcinogenesis in male ICR mice, Carcinogenesis, 29:1057-1063, 2008.

0170B003

Y.Yasui, S.Miyamoto, M.Kim, H.Kohno, S.Sugie, T.Tanaka: Aqueous and ethanolic extract fractions from theBarazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Oncol. Rep., 20:493-499, 2008.

0170B004

M.Kim, S.Miyamoto, S.Sugie, Y.Yasui, R.Ishigamori-Suzuki, A.Murakami, H.Nakagama, T.Tanaka: A tobaccospecific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice, In Vivo., 22:557564, 2008.

0170B005(S.Miyamoto), F.Epifano, M.Curini, S.Genovese, M.Kim, R.Ishigamori-Suzuki, Y.Yasui, S.Sugie, T.Tanaka: A novel
prodrug of 4’-geranyloxy-ferulic acid suppresses colitis-related colon carcinogenesis in mice, Nutr. Cancer.,
60:675-684, 2008.

－ 22 －

0170B006(Y.Shirakami), M.Shimizu, H.Tsurumi, Y.Hara, T.Tanaka, H.Moriwaki: EGCG and polyphenon E attenuate
inflammation-related mouse colon carcinogenesis induced by AOM plus DSS, Molecular Medicine Reports., 1:355361, 2008.

0170B007(M.Shimizu), Y.Shirakami, H.Sakai, S.Adachi, K.Hata, Y.Hirose, H.Tsurumi, T.Tanaka, H.Moriwaki: (-)Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db
mice, Cancer Prev. Res. (Phila. Pa)., 1:298-304, 2008.

Reviews
0170C001

T.Tanaka, Y.Yasui, R.Ishigamori-Suzuki, T.Oyama: Citrus compounds inhibit inflammation- and obesity-relatedcolon carcinogenesis in mice, Nutr. Cancer., 60(Suppl.1):70-80, 2008.

0170C002

Y.Yasui, M.Kim, T.Tanaka: PPAR ligands for cancer chemoprevention, PPAR Res., 2008:548919, 2008.

Case Reports
0170D001

K.Sato, T.Odake, T.Hashimoto, H.Nishida, Y.Ueda, T.Tanaka, S.Katsuda: A case of peritoneal deciduoid
mesothelioma, J. Jpn. Soc. Clin. Cytol., 47:306-309, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0170I001(M.Shimizu), Y.Shirakami, K.Hats, Y.Hirose, T.Tanaka, H.Moriwak: EGCG suppresses obesity-related colonicpreneoplastic lesions in C57BUKsJ-dbldb mice, 2008 AACR Annual Meeting, (San Diego,CA, '08.04).

0170I002(Y.Shirakami), M.Shimizu, H.Sakai, H.Tatebe, Y.Hara, T.Tanaka, H.Moriwaki: EGCG suppresses tumor growth by
inhibiting activation of the VEGFNEGFR axis in the xenograft model of human colon cancer and hepatoma, 2008
AACR Annual Meeting, (San Diego,CA, '08.04).

0170I003

Y.Yasui, S.Miyamoto, M.Kim, T.Oyama, S.Sugie, A.Murakami, T.Tanaka: Zerumbone, a tropical ginger
sesquiterpene, inhibits colon and lung carcinogenesis in mice, 4th International Niigata Symposium on Diet and
Health - “Integrative Functions of Diet in Anti-aging and Cancer Prevention”, (Niigata, '08.11).

－ 23 －

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

KATSUDA Shogo

Vascular pathology, Pathophysiology of ECM

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

SATO Katsuaki

Neuropathology

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

Z-P.Zong, S.Matsui, J-F.Han, S.Katsuda, ML.Fu: Involvement of thymus in amiodarone-treated autoimmune
myocarditis in rats, Int. J. Cardiol., 125:122-129, 2008.

0180B002(J-l.Wu), S.Matsui, Z-P.Zong, K.Nishikawa, B-G.Sun, S.Katsuda, M.Fu: Amelioration of myocarditis by statin
through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats, J. Mol. Cell. Cardiol.,
44:1023-1031, 2008.

0180B003

G.Ma, X.Zhao, M.Ueno, M.Tanaka, Y.Machida, H.Aikawa, K.Usuda, M.Sagawa, Y.Ueda, T.Sakuma: Increased
reabsorption of alveolar edema fluid in the obese zucker rat, Tohoku J. Exp. Med., 216:223-230, 2008.

0180B004(Y. Kanazawa), Y. Ueda, M. Shimasaki, S. Katsuda, N. Yamamoto, K. Tomita, H. Tsuchiya: Down-regulation ofplakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis, Anticancer Res.,
28:655-664, 2008.
0180B005(S. Ii), Y. Ueda, M. Shimasaki, S. Katsuda, K. Takazawa, Y. Kanazawa, K. Tomita, H. Tsuchiya: Identification ofnovel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray,
Anticancer Res., 28:645-653, 2008.

Reviews－ 24 －

0180C001

Y.Ueda, M.Shimasaki, K.Higashi, G.Guo, K.Sato, M.Sagawa, T.Sakuma, S.Katsuda: Recent advance in thepathology of lung cancer, J. Kanazawa. Med. Univ., 33:21-30, 2008 (in Japanese) .

Case Reports
0180D001

K.Sato, Y.Shimode, M.Hirokawa, Y.Ueda, S.Katsuda: Thyroid adenomatous nodule with bizarre nuclei: a casereport and mutation analysis of the p53 gene, Pathol. Res. Pract., 204:191-195, 2008.

0180D002

K.Sato, Y.Ueda, H.Tachibana, K.Miyazawa, I.Chikazawa, S.Kaji, T.Nojima, S.Katsuda: Malignant epithelioid
angiomyolipoma of the kidney in a patient with tuberous sclerosis: An autopsy case report with p53 gene mutation
analysis., Pathol. Res. Pract., 204:771-777, 2008.

0180D003

K.Sato, Y.Ueda, S.Miwa, A.Yokogawa, M.Ozaki, S.Katsuda: Low-grade malignant soft-tissue perineurioma:
interphase fluorescence in situ hybridization, Pathol. Int., 58:718-722, 2008.

0180D004

M.Sagawa, H.Aikawa, K.Usuda, Y.Machida, M.Tanaka, M.Ueno, Y.Ueda, T.Sakuma: Extended sleeve pulmonary
resection in patient with synchronous triple bronchogenic squamous cell carcinoma, Lung Cancer, 59:262-265,
2008.

0180D005

K.Sato, M.Nakano, T.Terauchi, M.Takenaka, Y.Asakura, S.Kaji, T.Nojima, Y.Ueda: A case of large cell lungcarcinoma with rhabdoid phenotype, J. Jpn. Soc. Clin. Cytol., 47:64-68, 2008 (in Japanese) .

0180D006

K.Sato, T.Terauchi, Y.Asakura, M.Takenaka, M.Nakano, N.Kurose, Y.Ueda, M.Hirokawa: A case of thyroid
oxyphilic follicular carcinoma with distinct trabecular growth pattern, J. Jpn. Soc. Clin. Cytol., 47:200-204, 2008
(in Japanese) .

0180D007

K.Sato, Y.Uwami, M.Ariga, Y.Nishida, K.Tanimoto, Y.Ueda, S.Katsuda: A case of pleural sarcomatoid
mesothelioma, J. Jpn. Soc. Clin. Cytol., 47:301-305, 2008 (in Japanese) .

0180D008

K.Sato, T.Odake, T.Hashimoto, H.Nishida, Y.Ueda, T.Tanaka, S.Katsuda: A case of peritoneal deciduoid
mesothelioma, J. Jpn. Soc. Clin. Cytol., 47:306-309, 2008 (in Japanese) .

0180D009

M.Takenaka, K.Sato, T.Terauchi, M.Yamashita, Y.Asakura, M.Nakano, N.Kurose, T.Nojima: A case of diffuse large
B-cell lymphoma hardly differentiating from high-grade urothelial carcinoma in cytology, J. Jpn. Soc. Clin. Cytol.,
47:296-300, 2008 (in Japanese) .

Others0180F001

M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase: Successful rituximab
monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of thetransverse colon in a patient with liver cirrhosis, Scand. J. Gastroenterol., 43:761-764, 2008.

－ 25 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

OHARA Yoshiro

Neurovirology，Neuroimmunology

SAITO Mineki

Neurology，Neurovirology

TANIURA Naoko

Neurovirology

SAITO Kousuke

Virology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001(E.Matsuura), F.Umehara, H.Nose, I.Higuchi, E.Matuoka, K.Izumi, R.Kubota, M.Saito, S.Izumo, K.Arimura,
M.Osame: Inclusion body myositis associated with human T-lymphotropic virus-type 1 infection: eleven patientsfrom an endemic area in Japan., J. Neuropathol. Exp. Neurol., 67: 41-49, 2008.

0190B002(M.Yukitake), E.Sueoka, N. Sueoka-Aragane, A.Sato, H.Ohashi, Y.Yakushiji, M.Saito, M.Osame, S.Izumo,
Y.Kuroda: Significantly increased antibody response to heterogeneous nuclear ribonucleoproteins in cerebrospinal
fluid of multiple sclerosis patients but not in patients with human T-lymphotropic virus type 1-associatedmyelopathy/tropical spastic paraparesis., J. Neurovirol., 14: 130-135, 2008.

0190B003

M.Saito, K.Usuku, K.Arimura, S.Izumo, M.Osame, Y.Ohara: Increased frequency of CD4+T cells expressing
fractalkine receptor CX3CR1 in patients with HTLV-1 associated myelopathy/tropical spastic paraparesis(HAM/TSP), but its AIDS susceptible polymorphisms are not associated with the disease., J. Neurol. Sci., 266: 1319, 2008.

0190B004(AH.Sabouri), K.Usuku, D.Hayashi, S.Izumo, Y.Ohara, M.Osame, M.Saito: Impaired function of human Tlymphotropic virus type 1 (HTLV-1) ―specific CD8+ T cells in HTLV-1―associated neurologic disease, Blood,
112: 2411-2420, 2008.

Presentations at Conference
International Conference (Presentations)
0190I001

Y.Ohara, N.Taniura, T.Okuwa, M.Saito, K.Saitou: A binding partner of L protein of Theiler's murine
encephalomyelitis virus (TMEV) and its potential role in virus persistence, American Academy of Neurology 60th
Annual Meeting, (Chicago, '08.06).

0190I002

N.Taniura, T.Okuwa, M.Saito, K.Saitou, Y.Ohara: Different subcellular localization of neurovirulent strain GDVII
and persistent strain DA of Theiler's murine encephalomyelitis virus leader protein, Europic 2008, (Barcelona,'08.07).

－ 26 －

0200

Department of Fundamental Research for CAM

Faculty
Title

Name

Field of Specialization

YAMAGUCHI Nobuo

Developmental immunology, Defense immunity, Tumor immunity,
Complementary & alternative medicine

SHIMIZU Shoji

Immunology, Protective immunology, Tumor immunology

MATSUBA Shintaro

Complementary & alternative medicine, Immunological pharmacology

SAKUMA Masahiro

Molecular and cellular immunology, Pathological examination studies,
Complementary & alternative medicine

Keywords of Researchpregnancy, maternal immunization, offspring, immune suppression, acquired immunodeficiency, immunomodulator, oral
immunity, herbal medicine, cytokine

Outline of Research
Our research is founded on immunology. To date, we have studied fields such as fetomaternal immunity, tumor immunity
and infectious immunity. With the graduate school reorganization in 2003, the name of the chair was changed with"Complementary and alternative medicine". Since then, we started the trial which verified alternative medicine of all thecountries of world by the immunological parameters. In order to achive these ends as effectively as possible, we planned the
publication of new international journal, Evidence-based Complementary and Alternative Medicine (eCAM). The journal
eCAM was published in 2004 and reached vol. 4th at present. In recent years, it has been proven that the neuroendocrinosystem adjusts the function of immune system and that there is a bidirectional regulation mechanism in these systems. We
examine the effect of hot spring hydrotherapy and walking exercise on number and function of the immunocompetent cells.
Hereafter, we aim at the establishment of an assessment of the alternative medicine throughout immunological parameters.

Publications
Originals
0200B001(H.Shen), M.Sakuma, S.Matsuba, N.Yamaguchi, I.Horiuchi: Culture condition of closed system for mycelia,

cordyceps militaris, Medicine and biology., 152:34-42, 2008.
0200B002

S.Matsuba, H.Matsuno, M.Sakuma, Y.Komatsu: Phellinus linteus extract augments the immune response in
Mitomycin C induced immunodeficient mice, Evid Based Complement Alternat Med, 5:85-90, 2008.

0200B003

R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda: Brain
atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), Neurochem.
Res., 33:1759-1767, 2008.

0200B004(K. Kawakita), T. Shichidou, E. Inoue, T. Nabeta, H. Kitakoji, S. Aizawa, A. Nishida, N. Yamaguchi, N. Takahashi,
E. Sumiya, K. Okada, T. Umeda, T. Yano, S. Tanzawa: Do Japanese style acupuncture and moxibustion reduce
symptoms of the common cold?, Evid Based Complement Alternat Med, 5:481-489, 2008.

0200B005

K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto:
Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats,
Hypertens. Res., 31:977-986, 2008.

－ 27 －

0210

Department of Medical Zoology

Name

Field of Specialization

IKEDA Teruaki

Immunological and biochemical studies of parasitic diseases

OIKAWA Yosaburo

diagnosis of parasitic disease，tick-borne disease

Faculty
Title

ICHIKAWA Hidetaka Immunological study for parasitic diseases

Keywords of Researchparasite, paragonimiasis, fascioliasis, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating
antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba,
metacercaria, excystment, atopic dermatitis, mite, Myobia musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Study on the invading mechanism of lung flukes into their final hosts.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Development of immunological and molecular biological diagnosis of parasitic diseases.

Publications
Originals
0210B001(A.Kobayashi), Y.Ishibashi, Y.Oikawa, H.Yokogawa, K.Sugiyama: In vivo and ex vivo laser confocal microscopy
findings in patients with early-stage acanthamoeba keratitis, Cornea, 27:439-445, 2008.

Reviews
0210C002(M.Tokoro), T.Yamaguchi, M.Tanaka, A.Kobayashi, Y.Oikawa: Current status of molecular taxonomy in pathogenic
protozoan parasites, Journal of the Juzen Medical Society., 117:53-57, 2008 (in Japanese) .

－ 28 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

FUKUNAGA
Toshiharu

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura
laboratory medicine, standardization of blood gas analysis, pulmonary
function test

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

NOJIMA Takayuki
MINATO Hiroshi

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001(T.Yamaguchi), A.Kawahara, H.Minato, S.Ota, K.Fujiyoshi, K.Ushijima, T.Kamura, M.Kage: Cytological study ofneuroendocrine tumors of the uterine cervix－Differential diagnosis from cervical squamous cell carcinoma andadenocarcinoma－, J. Jpn. Soc. Clin. Cytol., 47:86-94, 2008 (in Japanese) .

0220B002

T.Fukunaga: Detection of expiratory flow limitation during tidal breathing with slope of mouth pressure curve after
airflow linterruption, J. Kanazawa. Med. Univ., 33:13-20, 2008 (in Japanese) .

0220B003(J.Shimizu), M.Oda, I.Matsumoto, Y.Arano, N.Ishikawa, K.Saitoh, H.Minato: Clinicopathologic study of surgicallytreated cases of tracheobronchial adenois cystic carcinoma, Proceedings of the Japanese Lung Cancer Society
Lung cancer., 48:261-265, 2008 (in Japanese) .

Case Reports
0220D001(H.Takato), M.Yasui, Y.Ichikawa, M.Fujimura, S.Nakao, Y.Zen, H.Minato: Nonspecific interstitial pneumonia with
abundant IgG4-positive cells infiltration, which was thought as pulmonary involvement of IgG4-related autoimmune
disease, Intern. Med., 47:291-294, 2008.

－ 29 －

0220D002

K.Sato, Y.Ueda, H.Tachibana, K.Miyazawa, I.Chikazawa, S.Kaji, T.Nojima, S.Katsuda: Malignant epithelioid
angiomyolipoma of the kidney in a patient with tuberous sclerosis: An autopsy case report with p53 gene mutation
analysis., Pathol. Res. Pract., 204:771-777, 2008.

0220D003(J.Shimizu), Y.Arano, T.Murata, N.Ishikawa, T.Yachi, T.Nomura, H.Minato: A case of intrathoracic giant malignant
peripheral nerve sheath tumor in neurofibromatosis type I (von recklinghausen's disease), Ann Thorac Cardiovasc
Surg, 14:42-47, 2008.

0220D004

K.Sato, M.Nakano, T.Terauchi, M.Takenaka, Y.Asakura, S.Kaji, T.Nojima, Y.Ueda: A case of large cell lungcarcinoma with rhabdoid phenotype, J. Jpn. Soc. Clin. Cytol., 47:64-68, 2008 (in Japanese) .

0220D006

K.Sato, T.Terauchi, Y.Asakura, M.Takenaka, M.Nakano, N.Kurose, Y.Ueda, M.Hirokawa: A case of thyroid
oxyphilic follicular carcinoma with distinct trabecular growth pattern, J. Jpn. Soc. Clin. Cytol., 47:200-204, 2008
(in Japanese) .

0220D007

M.Takenaka, K.Sato, T.Terauchi, M.Yamashita, Y.Asakura, M.Nakano, N.Kurose, T.Nojima: A case of diffuse large
B-cell lymphoma hardly differentiating from high-grade urothelial carcinoma in cytology, J. Jpn. Soc. Clin. Cytol.,
47:296-300, 2008 (in Japanese) .

Others
0220F005

T.Nojima: Differential diagnosis on multinuclated osteoclast-type giant cell lesions, Pathology and clinicalmedicine., 26;990-991, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0220I001

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada,S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki,
K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara: Proposal for A new clinicalentity, IGG4-Positive Multi-Organ Lymphoproliferative syndrome : analysis of 64 cases of IGG4-Relateddisorders., 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

0220I002

E.Kinoshita, N.Kurose, H.Minato, T.Nojima: Clear cell adenocarcinoma coexisting with squamous cell carcinoma insitu of the uterine cervix: a case repor, Internationalcongress of the international academy of pathology, (Athens,'08.10)，Histopathology, 53:191, 2008.

0220I003

H.Minato, T.Nojima, N.Kurose, E.Kinoshita: Adenomatoid tumor of the pleura: a case report, International
congress of the international academy of pathology, (Athens, '08.10)，Histopathology, 53:355, 2008.

－ 30 －

0230

Department of Social and Environmental Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases

ISHIZAKI Masao

Occupational Health, Job stress

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

NOBORISAKA Yuka

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial changes in urinary
cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies,
Toxicol. Lett., 176:124-130, 2008.

0230B002(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, M.Nishiho, T.Kido, H.Nakagawa: Estimation of benchmark doses
as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and nonpolluted regions in Japan, Toxicology Lett., 179:108-112, 2008.

0230B003

Y.Morikawa, K.Miura, S.Sasaki, K.Yoshita, S.Yoneyama, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
M.Higashiyama, H.Nakagawa: Evaluation of the effects of shift work on nutrient intake:a cross-sectional study, J.
Occup. Health, 50:270-278, 2008.

0230B004(T.Ninomiya), Y.Kiyohara, Y.Tokuda, Y.Doi, H.Arima, A.Harada, Y.Ohashi, H.Ueshima, Japan Arteriosclerosis
Longitudinal Study Group, H.Nakagawa, K.Miura, Y.Morikawa, M.Ishizaki: Impact of kindey disease and bloodpressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal
Study., Circulation, 118:2694-2701, 2008.

0230B005

M.Ishizaki, H.Nakagawa, Y.Morikawa, R.Honda, Y.Yamada, N.Kawakami, The Japan Work Stress and HealthCohort Study Group: Influence of job strain on changes in body mass index and waist circumference-6-year
longitudinal study, Scand. J. Work Environ. Health, 34:288-296, 2008.

0230B006(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Changes in renal tubular andglomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculatedwith a general linear mixed model, Biol Trace Elem Res, 124:164-172, 2008.

－ 31 －

0230B007(T.Watanabe), M.Miyao, R.Honda, Y.Yamada: Hiroshima survivors exposed to very low doses of A-bomb primaryradiation showed a high risk for cancers, Environ. Health Prevent. Med., 13:264-270, 2008.

0230B008

M.Nishijo, K.Tawara, H.Nakagawa, R.Honda, T.Kido, H.Nishijo, S.Saito: 2,3,7,8-Tetrachlorodibenzo-p-dioxin inmaternal breast milk and newborn head circumference, J. Expo. Sci. Environ. Epidemiol., 18：246-251, 2008.

Others0230F002(C.Aoki), M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura,
Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse: Smoking cessation rate and its related
factors on a smoking cessation support program in a workplace, Hokuriku Japanese Journal of Public Health.,
35:36-38, 2008 (in Japanese) .

0230F003(C.Okamoto), M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura,
M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Effects of educational program
under a tutorial or a small-group system on body weight loss for obese participants in a workplace, Hokuriku
Japanese Journal of Public Health., 35:39-41, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0230I001

H.Osada, Y.Yamashiro, R.Honda, Y.Sakamoto, K.Nagai, Y.Kawakami, K.Sasaki, H.Sasaki: Posterior capsule
opacifiation in rural areas of China, The 7ｔｈ Asian Cataract Research Conference in Conjunction with Cataract
Satellite Meeting of the 18th International conference for Eye Research and the 11th Conference of Chinese
Cataract Society, (Xi'an, '08.09).

0230I002

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: Effect factors oflens thickness, The 7th Asian Cataract Research Conference in Conjunction with Cataract Satellite Meeting of the
18th international Conference for Eye Research and the 11th Conference of Chinese Cataract Society Clinical
Warkshop, (Xi'an, '08.09).

0230I003

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract, The 7th Asina Cataract Research Conference in Conjunction with Cataract satellite Meeting of the 18th
International Conference for Eye Research and the 11th Conference of Chinese Cataract Society, (Xi'an, '08.09).

0230I004

Y.Morikawa, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, H.Nakagawa, Y.Naruse, M.Higashiyama: Drinking habit
among shift workers and its health effects, 3rd ICOH International Conference on Psychosocial Factors at work,(Quebec, '08.09)，2008.

0230I005

K.Kitaoka, Y.Morikawa, S.Matsuda, K.Ogino, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Burnout and riskfactors for arteriosclerotic disease: follow-up study, 3rd ICOH International Conference on
Psychosocial Factors at work, (Quebec, '08.09)，2008.

－ 32 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology(Additional Post)

NAKANISHI Yumiko

Preventive medicine(Additional Post)

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial changes in urinary
cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies,
Toxicol. Lett., 176:124-130, 2008.

0240B002(Y.Kamon), T.Okamura, T.Tanaka, A.Hozawa, Z.Yamagata, T.Takebayashi, Y.Kusaka, S.Urano, H.Nakagawa,T.Kadowaki, Y.Miyoshi, H.Yamato, A.Okayama, H.Ueshima, HIPOP-OHP Research Group: Marital Status andCardiovascular Risk Factors among Middleaged Japanese Male Workers: The High-risk and Population Strategy for
Occupational Health Promotion (HIPOP-OHP) Study, J. Occup. Health, 50:348-356, 2008.

0240B003

K.Miura, A.Matumori, A.Nasermoaddeli, Y.Soyama, Y.Morikawa, M.Sakurai, A.Kitabatake, M.Nagai, Y.Inaba,
H.Nakagawa: Prognosis and prongostic factors in patients with idiopathic dilated cardiomyopathy in Japan―resultsfrom a nationwide study―, Circ. J., 72:343-348, 2008.

0240B004(Y.Hayashino), S.Fukuhara, T.Okamura, H.Yamato, H.Tanaka, T.Tanaka, T.Kadowaki, H.Ueshima, HIPOP-OHP
Research Group, H.Nakagawa, K.Miura: A prospective study of passive smoking and risk of deabetes in a cohort ofworkers:the high-risuk and population strategy for occupational health promotion (HIPOP-OHP) study, Diabetes
Care., 31:732-734, 2008.

－ 33 －

0240B005(M.Naito), T.Nakayama, T.Okamura, K.Miura, M.Yanagita, Y.Fujieda, F.Kinoshita, Y.Naito, H.Nakagawa,
T.Tanaka, H.Ueshima, HIPOP-OHP Research Group: Effect of a 4-year workplace-based physical activity
intervention program on the blood lipid profiles of participating employees:the high-risk and population strategy foroccupational health promotion(HIPOP-OHP) study, Atherosclerosis, 197:784-790, 2008.

0240B006(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, M.Nishiho, T.Kido, H.Nakagawa: Estimation of benchmark doses
as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and nonpolluted regions in Japan, Toxicology Lett., 179:108-112, 2008.

0240B007

Y.Morikawa, K.Miura, S.Sasaki, K.Yoshita, S.Yoneyama, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
M.Higashiyama, H.Nakagawa: Evaluation of the effects of shift work on nutrient intake:a cross-sectional study, J.
Occup. Health, 50:270-278, 2008.

0240B008(P.Elliott), H.Kesteloot, LJ.Appel, AR.Dyer, H.Ueshima, Q.Chan, IJ.Brown, L.Zhao, J.Stamler, INTERMAP
Cooperative Research Group, H.Nakagawa, K.Miura: Dietary phosphorus and blood pressure:international study ofmacro-and micro-nutrients and blood pressure, Hypertension, 51:669-675, 2008.

0240B009(Y.Murakami), A.Hozawa, T.Okamura, H.Ueshima, Evidence for Cardiovascular Prevention From Observational
Cohorts in Japan Reserch Group (EPOCH-JAPAN), H.Nakagawa, K.Miura: Relation of blood presssure and allcause mortality in 180 000 Japanese participants:pooled analysis of 13 cohort studies, Hypertension, 51:14831491, 2008.

0240B010

K.Sunaga, K.Miura, Y.Naruse, M.Sakurai, Y.Morikawa, Y.Kurosawa, H.Nakagawa: Glycated hemoglobin and risk ofstroke, ischemic and hemorrhagic, in Japanese men and women, Cerebrovasc. Dis., 26:310-316, 2008.

0240B011

K.Miura, J.Stamler, H.Nakagawa, P.Elliott, H.Ueshima, Q.Chan, IJ.Brown, I.Tzoulaki, S.Saitoh, AR.Dyer,
ML.Daviglus, H.Kesteloot, A.Okayama, JD.Curb, BL.Rodriguez, PJ.Elmer, LM.Steffen, C.Robertson, L.Zhao,
International Study of Macro-Micronutrients and Blood Pressure Reserch Group: Relationship of dietary linoleic
acid to blood pressure:the international study of macro-micronutrients and blood pressure study, Hypertension,
52:408-414, 2008.

0240B012

S.Yoneyama, K.Miura, K.Itai, K.Yoshita, H.Nakagawa, T.Shimmura, A.Okayama, K.Sakata, S.Saitoh, H.Ueshima,
P.Elliott, J.Stamler, INTERMAP Research Group: Dietary intake and urinary excretion of selenium in the Japanese
adult population: the INTERMAP Study Japan, Eur. J. Clin. Nutr., 62:1187-1193, 2008.

0240B013(Japan Arteriosclerosis Longitudinal Study(JALS) Group), H.Nakagawa: Japan arteriosclerosis longitudinal studyexisting cohorts combine(JALS-ECC)-rationale, design, and population characteristics-, Circ. J., 72:1563-1568,
2008.

0240B014(T.Ninomiya), Y.Kiyohara, Y.Tokuda, Y.Doi, H.Arima, A.Harada, Y.Ohashi, H.Ueshima, Japan Arteriosclerosis
Longitudinal Study Group, H.Nakagawa, K.Miura, Y.Morikawa, M.Ishizaki: Impact of kindey disease and bloodpressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal
Study., Circulation, 118:2694-2701, 2008.

0240B015

M.Ishizaki, H.Nakagawa, Y.Morikawa, R.Honda, Y.Yamada, N.Kawakami, The Japan Work Stress and HealthCohort Study Group: Influence of job strain on changes in body mass index and waist circumference-6-year
longitudinal study, Scand. J. Work Environ. Health, 34:288-296, 2008.

0240B016(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Changes in renal tubular andglomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculatedwith a general linear mixed model, Biol Trace Elem Res, 124:164-172, 2008.

0240B017

M.Nishijo, K.Tawara, H.Nakagawa, R.Honda, T.Kido, H.Nishijo, S.Saito: 2,3,7,8-Tetrachlorodibenzo-p-dioxin inmaternal breast milk and newborn head circumference, J. Expo. Sci. Environ. Epidemiol., 18：246-251, 2008.

0240B018(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

0240B019(H.Ueda), A.Higashiyama, A.Okayama, T.Okamura, N.Okuda, K.Yoshita, S.Saitoh, K.Sakata, SR.Choudhury,
T.Kadowaki, Y.Kita, K.Miura, H.Nakagawa, M.Watanabe, H.Ueshima, INTERMAP Japan Research Group: Obestiyand percentage energy from fat: the INTERMAP study of middle-age Japanese men, Japanese journal of
cardiovascular disease prevention., 43:123-131, 2008 (in Japanese) .

－ 34 －

0240B020(M.Nozue), N.Sarukura, M.Nishijo, H.Fujii, Y.Arai, A.Ishiwaki, N.Yoshiike, H.Nakagawa, K.Yoshita: A study on
seasonal variations in nutrients and food groups and the relation between vegetable consumption andnutrients/food groups in a rural ares of Toyama, Hokuriku Japanese Journal of Public Health., 34:58-64, 2008 (inJapanese) .

0240B021

M.Nakashima, K.Miura, Y.Morikawa, M.Nishijo, Y.Nakanishi, M.Sakurai, H.Nakagawa: Effect of smoke-free medical
school on smoking behavior of medical students, Japanese Journal of Public Health., 55:647-654, 2008 (inJapanese) .

Short Communications
0240E001

M.Nishijo, S.Maruzeni, K.Tawara, T.Kido, Nhu.DD, Naganuma.R, H.Suzuki, Hung.TM, Dung.PT, Thom.LH,
H.Nakagawa: Porychlorinated-dibenzo-p-dioxins/Furans and pregnancy outcome among vietnamese women living
in a herbicide sprayed area, Organohalogen Compounds., 70:1882-1885, 2008.

0240E002(T.Kido), R.Naganuma, H.Suzuki, Nhu.DD, K.Saito, M.Nishijo, H.Nakagawa, K.Tawara, Hung.NN, Thom.LH,
Dung.PT: The relationship between visualacuity and dioxin levels of breast milk in the herbicide sprayed and nonsprayed areas in vietnam, Organohalogen Compounds., 70:550-553, 2008.

Others
0240F001

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H.Nakagawa: BMI may be better than waist circumference for defining
metabolic syndrome in Japanese women, Diabetes Care., 31:e12, 2008.

0240F002(T.Kido), S.Maruzeni, H.suzuki, Y.Odamae, M.Marunaka, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa,
TM.Hung, LTH.Thom, PT.Dung, DD.Nhu, H.Oka, K.Noguchi: Five years studies on the long term effects of war
ahent orange/dioｘinn on human health in fietnam, Grant-in-Aid for Scientific Research (B) (2005～2007), 1-37,
2008.

0240F011(C.Aoki), M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura,
Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse: Smoking cessation rate and its related
factors on a smoking cessation support program in a workplace, Hokuriku Japanese Journal of Public Health.,
35:36-38, 2008 (in Japanese) .

0240F012(C.Okamoto), M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura,
M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Effects of educational program
under a tutorial or a small-group system on body weight loss for obese participants in a workplace, Hokuriku
Japanese Journal of Public Health., 35:39-41, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0240I001

M.Sakurai, K.Miura, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of long-term body weight change to HDL particle size change in Japanese men and women:The
INTERMAP Toyama study. Joint conference, 49th Cardiovascular Disease Epidemiology and Prevention -andNutrition, (Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

0240I002

K.Miura, M.Sakurai, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of 9-year body weight change to change in LDL particle size in Japanese men and women:The INTERMAP
Toyama study, Joint Conference -49th Cardiovascular Disease Epidemiology and `revention -and- Nurtrition,(Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

0240I003

M.Nishijo, S.Maruzeni, K.Tawara, T.Kido, N.DD, R.Naganuma, H.Suzuki, H.TM, D.PT, T.LTHN, H.Nakagawa:Porychlornated-dibenzo-p-dioxins/furans and pregnancy outcome among vietnamesewomen living in a herbbicide
sprayed area, 28th International Symposium on Halogenated Presistent Organic Pollutans (POPs), (Birmingham,'08.08)，LOOKING TO THE FUTURE DEVELOPING THE NEXT GENERATION, 1882-1884, 2008.

－ 35 －

0240I004(H.Horikawa), H.Suzuki, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa, H.NN, T.LTH, D.PT, N.DD, V.PT,
B.NT, W.T, T.Kido, Y.Sato: Relation between dioxins levels in human breast milk samples and SCE values amonglactating females in a defoliants-sprayes area in Vietnam, 28th International Symposium on Halogenated Presistent
Organic Pollutans (POPs), (Birmingham, '08.08)，LOOKING TO THE FUTURE:DEVELOPING THE NEXT
GENERATION, 646-648, 2008.

0240I005(T.Kido), R.Naganuma, H.Suzuki, D.D.N, K.Sato, M.Nishijo, H.Nakagawa, K.Tawara, N.N.H, L.H.T, P.T.D.PT:
The relationship between visual acuty and dioxin levels of breast milk in the herbicide sprayed and non-sprayedareas in Vietnam, 28th International Symposium on Halogenated Presistent Organic Pollutans (POPs),(BIRMINGHAM, '08.08)，LOOKING TO THE FUTURE:DEVELOPING THE NEXT GENERATION, 550-552,
2008.

0240I006

Y.Morikawa, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, H.Nakagawa, Y.Naruse, M.Higashiyama: Drinking habit
among shift workers and its health effects, 3rd ICOH International Conference on Psychosocial Factors at work,(Quebec, '08.09)，2008.

0240I007

K.Kitaoka, Y.Morikawa, S.Matsuda, K.Ogino, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Burnout and riskfactors for arteriosclerotic disease: follow-up study, 3rd ICOH International Conference on
Psychosocial Factors at work, (Quebec, '08.09)，2008.

－ 36 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

KITAMURA Osamu

Forensic Pathology，Drug Dependence

TAKEICHI Toshiaki

hemorheologe

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Presentations at Conference
International Conference (Key Note Lecture)
0250G001

O.Kitamura: Detection of methamphetamine neurotoxicity in forensic autopsy cases, 7th International Symposium
ADVANCES IN LEGAL MEDICINE, (Osaka, '08.09)，THE JAPANESE JOURNAL OF LEGAL MEDICINE, 62:73,
2008.

International Conference (Presentations)
0250I001

T.Takeichi, O.Kitamura: Detection of diatom in formalin-fixed organs by enzymatic digestion, 7th International
Symposium ADVANCES IN LEGAL MEDICNE, (Osaka, '08.09)，THE JAPANESE JOURNAL OF LEGALMEDICINE, 62:149, 2008.

－ 37 －

0260

Department of Medical Education

Name

Field of Specialization

Faculty
Title

YASUDA Yukio
HORI Ariyuki
KURODA Naohiro

undergraduate clinical teaching, graduate education of physicians,
medical education
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

－ 38 －

0300

Department of Cardiovascular Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

MATSUI Shinobu

Heart failure

TSUGAWA Hiroichi

Arrhythmia, Catheter ablation

ASAJI Takayoshi

Heart failure

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention
KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

UENISHI Hiroaki

Ischemic heart disease, Coronary intervention

AKAO Hironobu

Ischemic heart disease, Coronary intervention

TAKEDA Kenji

Molecular Biology

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

SATAKE Osamichi

Cardiomyopathy

SATO Ryoko

Ischemic heart disease, Coronary intervention

KASENO Kenichi

Arrhythmia, Catheter ablation

NOMURA Yusuke

nuclear cardiology

MOTOYAMA Atsushi Ischemic heart disease，Coronary intervention
ISHIDA Masaski

Hypertension

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001

Z-P.Zong, S.Matsui, J-F.Han, S.Katsuda, ML.Fu: Involvement of thymus in amiodarone-treated autoimmune
myocarditis in rats, Int. J. Cardiol., 125:122-129, 2008.

0300B002

K.Takeda, S.Akazawa, Y.Kawai, K.Kajinami: Regulation of pssitive feedback loop of HB-EGF signal by gene
33/ralt in H9c2 cells, J. Kanazawa. Med. Univ., 33:76-85, 2008.

－ 39 －

0300B003(J-l.Wu), S.Matsui, Z-P.Zong, K.Nishikawa, B-G.Sun, S.Katsuda, M.Fu: Amelioration of myocarditis by statin
through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats, J. Mol. Cell. Cardiol.,
44:1023-1031, 2008.

0300B004

K.Kaseno, H.Tada, K.Koyama, M.Jingu, S.Hiramatsu, M.Yokokawa, K.Goto, S.Naito, S.Oshima, K.Taniguchi:
Prevalence and characterization of pulmonary vein variants in patients with atrial fibrillation determined using 3dimensional computed tomography, Am. J. Cardiol., 101:1638-1642, 2008.

0300B005(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

0300B006(Chun Yuan), Y.Kawai, S.Inaba, K.Arakawa, M.Katsuyama, K.Kajinami, T.Yasuda, C.Yabe-Nishimura,
T.Konoshita, I.Miyamori: Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy
through up-regulation of NOX1, J. Steroid Biochem. Mol. Biol., 111:29-36, 2008.

Reviews
0300C001

A.Motoyama, H.Akao, K.Kajinami: LDL apheresis int the prevention of coronary atherosclerosis, Japanese journalof apheresis., 27:42-46, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0300I001

H.Akao, M.Kitayama, Y.Kawai, H.Uenishi, A.Motoyama, R.Sato, M.Wakasa, K.Kajinami: Opposite role ofosteopontin(OPN) and matrix gia protein(MGP) in advanced coronary atherosclerosis in patients treated withcoronary rotational atherectomy(RA), Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference
2008, (Atlanta, '08.04).

0300I002

H.Akao, M.Kitayama, H.Uenishi, R.Sato, A.Motoyama, K.Kaseno, Y.Nomura, M.Wakasa, K.Kajinami: Differential
role of calcification related molecules in advanced coronary atherosclerosis, ESC Congress 2008, (Munich, '08.08).

－ 40 －

0310

Department of Respirology (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

TOGA Hirohisa

lung physiology, sleep disordered breathing

OSANAI Kazuhiro

lung cell and molecular biology , COPD

HUANG Jyongsu

lung physiology, sleep disordered breathing

IGUCHI Masaharu

clinical respiratory medicine

TAKAHASHI
Masakatsu

clinical respiratory medicine , pulmonary tuberculosis

TOBE Takeyasu

clinical respiratory medicine

TSUCHIHARA
Katsumaclinical respiratory medicine

OIKAWA Taku

clinical respiratory medicine , lung cancer

NAKAGAWA Kenclinical respiratory medicine , lung cancer

FUJIMOTO Yuki

clinical respiratory medicine

KOJIMA Koji

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, NO, matrix metalloproteinase, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic
reflection technique, upper airway compliance, CPAP, BiPAP, lung cancer, apoptosis, Fas, Fas ligand

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Apoptosis of lung cancer cells

Books
0310A005

K.Osanai, D. R. Voelker: Analysis and expression of Rab38 in oculocutaneous lung disease, Small GTPases indisease, Part A, 203-215, Academic Press, USA, 2008.

Publications
Originals
0310B001

K.Osanai, R.Oikawa, J.Higuchi, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, H.Toga, D.R.Voelker: A mulationin rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice, Am. J.
Pathol., 173:1265-1274, 2008.

0310B002

M.Sagawa, K.Usuda, K.Tsuchihara, H.Aikawa, Y.Machida, M.Tanaka, M.Ueno, K.Nakagawa, T.Sakuma:
Conparison of the images of virtual bronchoscopy under the different conditions, Ｔhe Japanese journal of thoracic
surgery., 61:102-108, 2008 (in Japanese) .

－ 41 －

0310B004

H.Aikawa, M.Sagawa, M.Tanaka, Y.Machida, M.Ueno, K.Usuda, T.Tobe, H.Toga, T.Sakuma: Endobronchial
treatment using spiral-z stent and electrosurgery, J. Kanazawa. Med. Univ., 33:141-144, 2008 (in Japanese) .

Case Reports
0310D001

R. Oikawa, Y. Takahara, A. Yamaya, M. Saito, K. Kojima, Y. Tachi, T. Oikawa, K. Nakagawa, K. Tsuchihara, M.
Iguchi, T. Tobe, M. Takahashi, J. Huang, K. Osanai, H. Toga: A case of broncholithiasis lithoptysis occurring
spontaneously after repeated pneumonia, The journal of the Japanese Respiratory Society., 46:126-130, 2008 (inJapanese) .

－ 42 －

0320

Department of Gastroenterology

Name

Field of Specialization

Faculty
Title

KAWAHARA Hiromu Liver injury and oxidative stress(Additional Post)

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer
FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

FUKURA Masayuki

Chemotherapy of advanced hepatic cancer

YANO Hirokazu

Clinico-epidemiology of alcoholic liver injury

OOTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

HAYASHI Nobuhiko

Effect of alcohol on colon carcinogenesis by chemical carcinogen

YAMADA Masayoshi

Nonalcoholic steatohepatitis and oxidative stress

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals－ 43 －

0320B001(T.Tahara), T.Shibata, H.Yamashita, I.Hirata, T.Arisawa: Effect of cyclin D1(CCND1)polymorphism on gastricpremalignant condition, Clin. Chem. Lab. Med., 46:1696-1701, 2008.

Others
0320F001

M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase: Successful rituximab
monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of thetransverse colon in a patient with liver cirrhosis, Scand. J. Gastroenterol., 43:761-764, 2008.

－ 44 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

ASAKA Mitsuhiro

Cellular immunity in uremia, Clinicopathological study of primary
nonfunction and chronic allograft nephropathy in renal transplantation

YAMAYA Hideki

Clinical nephrology,

ADACHI Hiroki

Clinical nephrology,

OKUYAMA Hiroshi

Clinical nephrology,

CHIKAZAWA
Yoshihiro

Clinical nephrology,

NAKAGAWA Masaru Clinical nephrology,
HAYAMA Satoshi

Clinical nephrology,

MORITA Kyoko

Clinical nephrology,

ATSUMI Hirokatsu

Clinical nephrology.

IMURA Junko

Clinical nephrology.

FUJIMOTO Keiji

Clinical nephrology.

KIMURA Shogo

Clinical nephrology.

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

Publications
Originals－ 45 －

0330B001

H.Yokoyama, T.Kawaguchi, T.Wada, Y.Takahashi, T.Higashi, S.Yamazaki, S.Fukuhara, T.Akiba, T.Akizawa,
Y.Asano, K.Kurokawa, A.Saito: Biocompatibility and permeability of dialyzer membranes do not affect anemia,
erythropoietin dosage or mortality in Japanese patients on chronic non-reuse hemodialysis:a prospective cohort
study from the J-DOPPS II study, Nephron Clin. Pract., 109:c100-ｃ108, 2008.

0330B002

M.Asaka, H.Imamura, K.Sato, H.Atsumi, H.Okuyama, H.Yamaya, H.Yokoyama, I.Ishikawa: Ischemia-reperfusion
injury as the leading cause of primary non-function in renal transplantation using donors with prolonged warm
ischemic time, Clin. Transplant., 22(Suppl 19):19-24, 2008.

Reviews
0330C006

H.Yokoyama, H.Yamaya: Urinalysis in chronic kidney diseases, Nipponrinsho., 66：1713-1718, 2008 (in Japanese) .

Case Reports
0330D001

M.Nakagawa, S.Kimura, K.Fujimoto, H.Atsumi, J.Imura, Y.Chikazawa, H.Imamura, H.Okuyama, H.Yamaya,
T.Fukushima, A.Nakagawa, M.Asaka, H.Yokoyama: A case report of an adult with severe hyperlipidemia during
acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis, Ther Apher Dial, 12:509513, 2008.

0330D002(H.Suzuki), F.Ito, H.Nakazawa, Y.Maeda, K.Yoshida, H.Tomoe, N.Tomosugi: Perioperative management in a
maintenance hemodialysis patient with congenital antithrombin Ⅲ deficiency undergoing surgery for renal cell
carcinoma, J. Jpn. Soc. Dial. Ther., 41:641-645, 2008 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0330H001

H.Yokoyama: Chronic allograft injury (CAI) as the aspect of chronic kidney disease (CKD), The 38th Annual
Congress of the Korean Society for Transplantation ＆ The 7 th Korea-Japan Transplantation Forum, (Seoul,'08.10).

International Conference (Presentations)
0330I001(M.Horio), E. Imai, T.Konta, K.Yamagata, K.Iseki, S.Hara, N.Ura, Y.Ando, T.Moriyama, Y.Kiyahara, H.Yokoyama,
S.Fujimoto, T.Watanabe, H.Makino, A.Hishida, S.Matsuo: Update of the estimated prevalence of CKD in Japan
from recent annual health checkup data of 574,024 subjects, Renal Week 2008 ASN`s 41st Annual Meeting ＆Scientific Exposition, (Philadelphia, '08.11)，J.Am.Soc.Nephrol, 19:534A, 2008.

0330I002

H.Yokoyama, M.Asaka, S.Kimura, H.Atsumi, J.Imura, Y.Chikazawa, M.Nakagawa, H.Okuyama, H.Yamaya,
N.Tomosugi: Statins preserved the function of transplanted kidneys under controlled blood pressure, Renal Week
2008 ASN`s 41st Annual Meeting ＆Scientific Exposition, (Philadelphia, '08.11)，J.Am.Soc.Nephrol, 19:682A,
2008.

－ 46 －

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

KOYA Daisuke

diabetes, hypertension, obesity, aging

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterone secretion

NAKAGAWA Atsushi pancreatic and gut hormones, pituitary diseases(Additional Post)NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

IMAIZUMI Noriko

intracellular mechanisms of aldosterone synthesis, diabetes

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

FURUYA Keisuke

diabetes, thyroid diseases

MAEJIMA Katsuyuki

diabetes, thyroid diseases

KONISHI Kazunori

diabetes, arteriosclerosis

UEHARA Keigo

diabetes

KITADA Munehiro

diabetes, hypertension

FUJII Mizue

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals－ 47 －

0340B001(Y.Yokomaku), T.Sugimoto, S.Kume, S.Araki, K.Isshiki, M.Chin-Kanasaki, M.Sakaguchi, N.Nitta, M.Haneda,
D.Koya, T.Uzu, A.Kashiwagi: Asialoerythropoietin prevents contrast-induced nephropathy, J. Am. Soc. Nephrol.,
19:321-328, 2008.

0340B002

S.Tsuda, S.Nakano, K.Konishi, D.Koya: A lack of increase in high molecular weight-adiponectin inmacroalbuminuric subjects with metabolic syndrome may exert renal and atherosclerotic risks, Diabetes Res. Clin.
Pract., 79:503-509, 2008.

0340B003(The Shiga microalbuminuria reduction trial (SMART) group), S.Nakano, D.Koya: Impact of renin-angiotensin
system inhibition on microalbuminuria in type 2 diabetes: a post hoc analysis of the Shiga Microalbuminuria
Reduction Trial (SMART), Hypertens. Res., 31:1171-1176, 2008.

0340B004

K.Konishi, S.Nakano, S.Tsuda, A.Nakagawa, T.Kigoshi, D.Koya: AST-120 (Kremezin) initiated in early stage
chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects, Diabetes Res. Clin.
Pract., 81:310-315, 2008.

0340B005(S.Araki), M.Haneda, D.Koya, A.Kashiwagi, T.Uzu, R.Kikkawa: Clinical impact of reducing microalbuminuria inpatients with type 2 diabetes mellitus, Diabetes Res. Clin. Pract., 82(Suppl.1):S54-S58, 2008.

0340B006

S.Abe, S.Ohta, K.Uchida: The effect of diastolic dysfunction and hypertension in diabetes mellitus－Examination ofleft ventricular diastolic dysfunction using the valsalva maneuver－, Journal of the Japan Diabetes Society.,
51:213-218, 2008 (in Japanese) .

Case Reports
0340D001

M.Nakagawa, S.Kimura, K.Fujimoto, H.Atsumi, J.Imura, Y.Chikazawa, H.Imamura, H.Okuyama, H.Yamaya,
T.Fukushima, A.Nakagawa, M.Asaka, H.Yokoyama: A case report of an adult with severe hyperlipidemia during
acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis, Ther Apher Dial, 12:509513, 2008.

Presentations at Conference
International Conference (Presentations)
0340I001(S.Kume), A.Kashiwagi, D.Koya: The role of mitochondrial biogenesis and SIRT1-PGC1alpha pathway on thedevelopment of age-associated kidney diseases, New Applications for Aging Research, (San Diego, CA, '08.01).

0340I002

K.Konishi, S.Nakano, S.Tsuda, A.Nakagawa, T.Kigoshi, D.Koya: AST-120 (Kremezin) initiated in early stage
chronic kidney disease stunts the progression of renal dysfunction in type 2 diabetic subjects, The Shiga
Internatrional Symposium on Diabetic Nephropathy, (Otsu, Japan, '08.03).

0340I003

M.Kitada, N.Imaizumi, D.Koya: Resveratrol was effective in protecting diabetic nephropathy, via normalizing MnSOD dysfunction, ISN Nexus Diabetes and the Kidney, (Dublin, Ireland, '08.06)，ISN Nexus Diabetes and theKidney; Final Program & Book of Abstracts, p12, 2008.

0340I004

Tsuda S, Nakano S, Konishi K, Koya D: The positive link between serum adiponectin level and occurrences ofcardiovascular disease, American Diabetes Association 68th Scientific Sessions, (San Francisco, CA, '08.06)，
Diabetes, 57(Suppl.1):A196, 2008.

0340I005(Kume S), Hirata K, Araki S, Nishiyama A, Sugimoto T, Koya D, Haneda M, Uzu T, Kashiwagi A: A GLP-1 analog,
exendin-4, attenuates the developments of renal injury and hypertension in type 2 diabetic db/db mice, American
Diabetes Association 68th Scientific Sessions, (San Francisco, CA, '08.06)，Diabetes, 57(Suppl.1):A205, 2008.

0340I006(Araki S), Matsuno H, Uzu T, Sugimoto T, Nishio Y, Maegawa H, Koya D, Haneda M, Kashiwagi A: Albuminuria is
an independent risk factor to induce spontaneous platelet micro-aggregation in patients with type 2 diabetes
mellitus, American Diabetes Association 68th Scientific Sessions, (San Francisco, CA, '08.06)，Diabetes,
57(Suppl.1):A207, 2008.

－ 48 －

0340I007

Kitada M, Imaizumi N, Nishizawa M, Nakagawa A, Koya D: Resveratrol protects against oxidative stress induced
diabetic nephropathy, American Diatetes Association 68th Scientific Sessions, (San Francisco, CA, '08.06)，
Diabetes, 57(Suppl.1):A219, 2008.

0340I008(Deji N), Kume S, Araki S, Sugimoto T, Isshiki K, Koya D, Haneda M, Uzu T, Kashiwagi A: Renal metabolic
functional and structural alterations in the mice fed on a high-fat diet, American Diabetes Association 68th
Scientific Sessions, (San Francisco，CA, '08.06)，Diabetes, 57(Suppl.1):A479, 2008.

0340I009

M.Kitada, N.Imaizumi, D.Koya: Effectiveness of resveratrol treatment in the improvement of oxidative stress andprotection against diabetic nephropathy via normalisation of Mn-SOD dysfunction, 44th EASD Annual Meeting,(Rome，Italy, '08.09).

0340I010

D.Koya: Control of mitochondrial turnover under the influence of SIRT1 in aged kidney, Renal week 2008,(Philadelphia，USA, '08.11).

－ 49 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

UMEHARA Hisanori

Hematology and Immunology

HIROSE Yuko

Hematology and Immunology,Transfusion Medicine

FUKUSHIMA
Toshihiro

Hematology and Immunology

MASAKI Yasufumi

Hematology and Immunology

TANAKA Masao

Rheumatology,Immunology

SAWAKI Toshioki

Hematology and Immunology

KAWANAMI Takafumi Hematology and Immunology
JIN Zhexiong

Immunology

Keywords of Research
autoimmune disorder, SjÖgren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A) Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1) Effects of chemokines on
vascular injury and Th1 response during chronic inflammation. 2) Function of microdomain (lipid rafts) on lymphocyte
activation and its contribution in autoimmune diseases. 3) Analysis of immunological disorder in sphingomyelin knockout
mice. 4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5) Detection of stem cells insalivary glands and its implication for regenerative medicine.
B) Studies of hematological malignancies and development of anti-cancer drugs. 1) Analysis of EB-virus proteins and theirroles in lymphoproliferative disorders. 2) Molecular biological analysis of drug resistance. 3) Roles of sphingomyelin on
apoptosis.

Publications
Originals
0350B001(K.Shimada), K.Matsue, K.Yamamoto, T.Murase, N.Ichikawa, M.Okamoto, N.Niitsu, H.Kosugi, N.Tsukamoto,H.Miwa, H.Asaoku, A.Kikuchi, M.Matsumoto, Y.Saburi, Y.Masaki, M.Yamaguchi, S.Nakamura, T.Naoe,
T.Kinoshita: Retrospective analysis of intravascular large B-Cell lymphoma treated with rituximab-containing
chemotherapy as reported by the IVL study group in Japan, J. Clin. Oncol., 26:3189-3195, 2008.

0350B002(T.Yamashita), T.Fukushima, T.Ueda: Pharmacokinetic self-potentiation of idarubicin by induction of anthracycline
carbonyl reducing enzymes, Leukemia and Lymphoma, 49:809-814, 2008.

0350B003

Z.Jin, C.Huang, L.Dong, S.Goda, T.Kawanami, T.Sawaki, T.Sakai, X.Tong, Y.Masaki, T.Fukushima, M.Tanaka,
T.Mimori, H.Tojo, E.Bloom, T.Okazaki, H.Umehara: Impaired TCR signaling through dysfunction of lipidrafts insphingomyelin synthase 1(SMS1)-knockdown T cells, Int. Immunol., 20:1427-1437, 2008.

－ 50 －

0350B004

C.Huang: Relationship between cisplatin-induced apoptosis and membrane sphingomyelin, J. Kanazawa. Med.
Univ., 33:91-97, 2008 (in Japanese) .

0350B005

Y.Saito, K.Naruhashi, N.Inoue, A.Kubo, Y.Takahashi, M.Kobori, Y.masaki, K.Nishio: Investigation of usefulness ofdrugs prescribed for supportive therapy for CHOP-related chemotherapy based on clinical pathway, Japanesejournal of pharmaceutical health care and sciences., 34:52-58, 2008 (in Japanese) .

Reviews
0350C001(S.Sugai), Y.Masaki: Current and prospective treatment options for Sjögren's syndrome, Expert Rev. Clin.
Immunol., 4:469-479, 2008.

Case Reports
0350D001

M.Nakagawa, S.Kimura, K.Fujimoto, H.Atsumi, J.Imura, Y.Chikazawa, H.Imamura, H.Okuyama, H.Yamaya,
T.Fukushima, A.Nakagawa, M.Asaka, H.Yokoyama: A case report of an adult with severe hyperlipidemia during
acute lymphocytic leukemia induction therapy successfully treated with plasmapheresis, Ther Apher Dial, 12:509513, 2008.

0350D002

T.Fukushima, L.Dong, T.Sakai, T.Sawaki, M.Miki, M.Tanaka, Y.Masaki, Y.Hirose, M.Kuwana, H.Umehara:
Successful treatment of amegakaryocytic thrombocytopenia with anti-CD20 antibody(rituximab)in a patient withsystemic lupus erythematosus, Lupus., 17:210-214, 2008.

Others
0350F001

M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase: Successful rituximab
monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of thetransverse colon in a patient with liver cirrhosis, Scand. J. Gastroenterol., 43:761-764, 2008.

Presentations at Conference
International Conference (Presentations)
0350I001(K.Matsue), K.Shimada, K.Yamamoto, T.Murase, N.Ichikawa, M.Okamoto, N.Niitsu, H.Kosugi, N.Tsukamoto,H.Miwa, H.Asaoku, A.Kikuchi, M.Matsumoto, Y.Saburi, Y.Masaki, M.Kashimura, T.Yoshida, M.Yamaguchi,
S.Nakamura, T.Naoe, T.Kinoshita: A retrospective analysis of eituximab-containing chemotherapies for
intravascular lage B-cell ymphoma, 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

0350I002(N.Tomita), N.Nakamura, K.Takeuchi, J.Koike, S.Motomura, K.Miyamoto, A.Kikuchi, R.Hyo, Y.Yakushijin,
Y.Masaki, S.Fujii, T.Hayashi, Y.Ishigatsubo, I.Miura: Clinicopathological features of lymphoma/ leukemia patients
carrying both BCL2 amd MYC translocations, 10th International Conference on Malignant Lymphoma,(Switzerland, '08.06).

0350I003

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada,S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki,
K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara: Proposal for A new clinicalentity, IGG4-Positive Multi-Organ Lymphoproliferative syndrome : analysis of 64 cases of IGG4-Relateddisorders., 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

0350I004

N.Tomosugi, K.Kitagawa, H.Tsuchida, H.Umehara: Identification and quantification of tear proteins in sjogren's,
HUPO 2008 'th WORLO CONGRESS, (Amsterdam, '08.08).

0350I005

H.Umehara: An Interim Report of SICCA-Internationa Sjögren Syndrome Registry, MEDICAL-EXPO 2008 in
APLAR's World, (Yokohama, '08.09).

0350I006

X.Tong: Prevalence And Relevance To Disease Manifestation Of Autoantibodies To RBP1-like protein(Rbik)inRheumatoid Arthritis, MEDICAL-EXPO 2008 in APLAR's World, (Yokohama, '08.09).

－ 51 －

0350I007(S.Sugai), Y.Masaki: Sjögren's syndrome and IgG4-related disorders(Mikulicz's disease), MEDICAL-EXPO 2008 in
APLAR's World, (Yokohama, '08.09).

0350I008(S.Sugai), Y.Masaki: Sjögren's syndrome and lymphoproliferative disorders, MEDICAL-EXPO 2008 in APLAR's
World, (Yokohama, '08.09).

0350I009(T.Daniels), K.Kitagawa, H.Tsuchida, H.Umehara: -SICCA- International sjogren's syndrome registry : Two Yearfollow-up analyses and elucidation of fow keratoconjunctivitis sicca subtypes, ACR/ARHP 08, (San Francisco,'08.10).

－ 52 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

MATSUI Makoto

Clinical neurology,Neuroimmunology,Clinical Immunology

TANAKA Keiko

Clinical neurology,Neuroimmunology

NAGAYAMA Shigeni

Clinical neurology,Neuroimmunology

KAWAMURA
Kazuyuki

Clinical neurology,Neuroimmunology

NAGAISHI Akiko

Clinical neurology

NAKANISHI Megumi

Clinical neurology,Neuroimmuology

KAITO Muichi

Clinical neurology

GONDO Yuichiro

Clinical neurology

ARAYA Shinichi

Neuroimmunology, Clinical Immunology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001

A.Nagaishi, M.Yukitake, Y.Kuroda: Long-term treatment of steroid-dependent myasthenia gravis patients with
low-dose tacrolimus, Intern. Med., 47:731-736, 2008.

Reviews
0360C001

M.Matsui: Multiple sclerosis immunology for clinicians, NEUROLOGY ASIA, 13:195-198, 2008.

0360C002

M.Matsui: Classification of MS and treatment strategy, Nipponrinsho., 66：1112-1116, 2008 (in Japanese) .

0360C005

M.Matsui: Progress in unravelling the etiology of multiple sclerosis?, Clinical Neurology., 48：849-852, 2008 (inJapanese) .

0360C006

K.Tanaka: The role of anti-aquaporin 4 antibody in NMO/OSMS, Neuroimmunol Neuroimmunology., 16：161-164,
2008 (in Japanese) .

Case Reports
0360D001

A.Nagaishi, H.Tanabe, M.Ueno, M.Mtsui, M.Matsui: A case of non-alcoholic pellagra following gastrectomy,
Clinical Neurology., 48：202-204, 2008 (in Japanese) .

－ 53 －

0360D002

S.Nagayama, F.Koike, T.Sakai, Y.Antoku, M.Yukitake, Y.Kuroda: A case of anti P/Q type VGCC antibody
positive small lung cell carcinoma that occured with subacute cerebellar degeneration, lambert-eaton myasthenic
syndrome, and brainstem encephalitis, Brain and nerve., 60：1470-1474, 2008 (in Japanese) .

Short Communications
0360E001

K.Tanaka, T.Tani, M.Tanaka, M.Nishizawa, K.Sakimura, M.Matsui: Anti-aquaporin 4 antibody test in a large series
of Japanese optic-spinal multiple sclerosis and neuromyelitis optica, NEUROLOGY ASIA, 13:203-204, 2008.

Presentations at Conference
International Conference (Key Note Lecture)
0360G001

M.Matsui: How to diagnose OSMS and NMO, Expert Meeting for sixth MS Forum Pan-Asian Conference,(Bangkok, '08.06).

0360G002

K.Tanaka: Research Update in Anti-AQP4 Testing, MS Forum Consensus, (Bangkok, '08.06).

0360G003

M.Matsui: MS Immunology for the Clinicians, 1st PACTRIMS Congress and 6th MS Forum, (Kuala Lumpur,'08.11).

International Conference (Presentations)
0360I001

K.Tanaka, T.Tani, M.Tanaka, M.Nishizawa, K.Sakimura, M.Matsui: NMO-IgG and anti-aquaporin 4 antibody
simultaneously examined in a large series of Japanese neuromyelitica optica, World congress on Treatment andResearch in Multiple Sclerosis, (Montreal, '08.09).

0360I002

M.Matsui, S.Araya, Y.Kitagawa, M.Nakata: Percentage of regulatory Tcell used to monitor inflammation in thecentral nervous system in comparison to systemic circulation in neurological patients with infection and multiple
sclerosis, 9th International Congress of NeuroImmunology, (Fort Worth,Texas, '08.10).

0360I003

K.Tanaka: Anti-Aquaporin4 antibody test in a large series of Japanese NMO/OSMS, 1st PACTRIMS, (Kuala
Lumpur, '08.11).

－ 54 －

0370

Department of Geriatric Medicine

Name

Field of Specialization

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis

Faculty
Title

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology
MURAI Hiroshi

Geriatrics, Gastroenterology, Dementia, Nutrition

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

ISHIGAMI Keiichiro

Geriatrics, Dementia

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis

OWARI Masaki

Geriatrics, Hypertension, Atherosclerosis

KATO Shouzaburo

Geriatrics, Hypertension, Atherosclerosis

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda: Brain
atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), Neurochem.
Res., 33:1759-1767, 2008.

0370B002

K.Nomura, H.Murai, T.Nakahashi, H.Tsuchiya, K.Iwai, S.Morimoto: Association seroprevalence of human
metapneumovirus with small vessel disease with dementia in elderly inpatients in Japan, J. Kanazawa. Med. Univ.,
33:86-90, 2008.

0370B003

F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda: Candesartan
improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, Int. J. Cardiol.,
129:414-421, 2008.

－ 55 －

0370B004

K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto:
Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats,
Hypertens. Res., 31:977-986, 2008.

Others
0370F001

K.Nomura, H.Murai, T.Nakahashi, S.Mashiba, Y.Watoh, T.Takahashi, S.Morimoto: Outbreak of norovirus
gastroenteritis in elderly evacuees after the 2007 Noto peninsula earthquake in Japan, J. Am. Geriatr. Soc.,
56:361-363, 2008.

0370F002

T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, K.Iwai, M.Atsumi, K.Ishigami, T.Inamatsu, S.Morimoto:
Association between seroprevalence of human metapneumovirus and c-reactive protein level and apolipoprotein eε4 allele in elderly inpatients in Japan, J. Am. Geriatr. Soc., 56:1758-1760, 2008.

Presentations at Conference
International Conference (Presentations)
0370I001

T.Kanda, K.Kusaka, T.Takahashi, J.Moriya, J.Yamakawa, R.Chen, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai:
Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute
myocarditis, Basic Cardiovascular Sciences Conference 2008, (Colorado, '08.07).

－ 56 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization(Additional Post)

KAKINUMA HiroakiChild neurology, Inborn errors of metabolism, Clinical genetics

YANASE Takuya

Pediatric hematology, Pediatric nephrology

NAKAMURA
Tsuneyuki

Pediatric cardiology

KOBAYASHI Azusa

Neonatology

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology
ITO Masatsune
YAMAMURA Junichi

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism.
Peditric Psychosomatic Disorder，Infectious Disease of Childhood，Clinical Virology，Fast and Easy Detection System for Infectiousagent

FUJIKI Takuma

Pediatric nephrology

SATO Hitoshi

Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

OKADA Naoki

Pediatric hematology, Pediatric oncology

IKEDA TomomiChild neurology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(S.Otomo), J.Yamamura, E.Hayashi, T.Nakamura, H.Kakinuma, Y.Nakamoto,, H.Takahashi, T.Karasawa: Analysisof childen with Chlamydophila(Chlamydia)pneumoniae and Mycoplasma pneumoniae respiratory infections by realtime PCR assay and serological tests, APMIS., 116:477-483, 2008.

0380B003

T.Nakamura, A.Kobayashi, C.Akita, C.Kitaoka, N.Okada, H.Sato, J.Yamamura, H.Kakinuma, H.Takahashi: Use of
new therapeutic agents in cardiovascular diseases of neonates in our hospital, Japanese journal of pediatrics., 61：
41‐45, 2008 (in Japanese) .

0380B005

T.Nakamura, J.Yamamura, T.Nakamura, H.Sato, Y.Mastue, Y.Saikawa: The current situation concerning theoutreach of the basic life support and the automated external defibrillator in the elementary and junior high schoolin the Noto area, Ishikawa Prefecture, Japanese Society of Emergency Pediatrics., 7:309-312, 2008 (in Japanese) .

－ 57 －

0380B006(Y.Adachi), G.Murakami, T.Nakamura, A.Yachie, Y.Ohshima, M.Mayumi: Use of a simple questionnaire andchecklist to implement childhood asthma guideline, Jpn. j. pediatr. allergy clin. immunol., 22:369-378, 2008 (inJapanese) .

Reviews
0380C001

H.Kakinuma, H.Sato: Copy-number variations associated with autism spectrum disorder, Pharmacogenomics,
9:1143-1154, 2008.

Case Reports
0380D001

C.Akita, T.Nakamura, H.Sato, H.Kakinuma: Recovery from lethal arrhythmia after weight gain in a patient with aneating disorder and epilepsy, Pediatr. Cardiol., 29:673-675, 2008.

0380D002

C.Akita, C.Kitaoka, T.Nakamura: A case of recurrent Kawasaki disease with severe cardiac sequelae, Progress in
Medicine, 28：1730-1734, 2008 (in Japanese) .

Short Communications
0380E001

H.Kakinuma, M.Ozaki, H.Sato, H.Takahashi: Variation in GABA-A subunit gene copy number in an autistic
patient with mosaic 4 p duplication (p12p16), Am. J. Med. Genet. B Neuropsychiatr. Genet., 147B:973-975, 2008.

Presentations at Conference
International Conference (Presentations)
0380I001

M.Ito, H.Kakinuma: Functional studies of a duplication mutation of valine at 235 by a transient expression assay ina boy with mct8 deficiency, SSIEM 2008, (Lisboa, '08.09)，JIMD, 31 Suppl 1:139, 2008.

0380I002

T.Horisawa, T.Komatsuzaki, Y.Saikawa: Computational Hematology in Systems Biology, 8th International
Conference on Cellular Automata for Research and Industry, (Yokohama, '08.09)，"Proceedings of 8thInternational Conference on Cellular Automata for Research and Industry Yokohama,", 23-26, 2008.

0380I003(K.Hirono), K.Ibuki, K.Saito, S.Watanabe, K.Watanabe, F.Ichida, T.Miyawaki, N.Yoshimura, C.Akita, T.Nakamura:
Bosentan induces clinical and hemodynamic impronement in candidates for right heart bypass surgery, AHA
Scientific Sessions, (New Orleans, '08.11).

－ 58 －

0390

Department of Neuropsychiatry

Name

Field of Specialization

JIBIKI Itsuki

Shizophrenia，Epilepsy，Brain imaging，Psychopharmacology，Senile
Demenｔia，Senile Psychosis

KUBOTA Takashi

Schizophrenia，Psychopharmacology，Epilepsy

IWASAKI Shinzo

Psycho Physiology，Neuropsy Chology，Brain Imaging

Faculty
Title

WATANABE Kenichiro Neuropsychology，Neuropharmacology
KITAMOTO Fukumi

Psychotherapy，Clinical Psychology

KOIZUMI Hazuki

Clinical Psychology，Cognitive-behaviora ltherapy

KOIWA Daisuke

Brain imaging，Schizophrenia

NANNO Hisatoshi

Schizophrenia

HIROYASU Kiwamu

Molecular Psychiatry，Schizophrenia, Epilepsy

KAWAMURA Tomomi Psychopharmacology，Neuropsychology
SHIMIZU Satoru

Ｂｒａｉｎ imaging

MASUDA Shinji

Schizophrenia

MONKAWA Akikazu

Brain imaging，Schizophrenia

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001

T.Kubota, I.Jibiki, A.Ishikawa, T.Kawamura, S.Kurokawa, M.Wang: Increase in extracellular dopamine levels during
clozapine-induced potentiation in the hippocampal dentate gyrus of chronically prepared rabbits, Can. J. Physiol.
Pharmacol., 86:249-256, 2008.

0390B002

清水 聰: Relations between VSRAD-based Parahippocampal Atrophy and Results of Neuropsychological Tests inPatients with Alzheimer’Disease and in Those with Mild Cognitive Impairment, J. Kanazawa. Med. Univ., 33:145152, 2008 (in Japanese) .

－ 59 －

Presentations at Conference
International Conference (Presentations)
0390I001

T.Kubota, A.Ishikawa, T.Kawamura, M.Sho, L.Xudong, I.Jibiki: Effects of atypical antipsychotics on excitatory
synaptic transmission,and dopamine and 5-HT levels in the hippocampus., 21Th ECNP Congress, (Barcelona,'08.09).

0390I002

T.Kubota, A.Ishikawa, T.Kawamura, M.Sho, L.Xudong, I.Jibiki: Effects of Antipsychotics on Synaptic
Transmission,and Dopamine and 5-HT Levels in the Hippocampus, 2nd WFSBP Asia-Pacific Congress and 30th
Annual Meeting of JSBP, (Toyama, '08.09)，THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 182,
2008.

0390I003

H.Koizumi, M.Hiraguchi: MMPI profile patteｒｎ of ocd patients and its changes after CBTinterventions:implications for treatment of resistant OCD, 38th EABCT Annual Congress, (Finland, '08.09).

－ 60 －

0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title

Name

Field of Specialization

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

YOKOTA Hajime

Gastrointestinal Radiology, MR Spectroscopy

OGUCHI Manabu

Radiation Therapy, Nuclear Medicine

TANIGUCHI Mitsuru

Cardiac Nuclear Medicine(Additional Post)

KUGINUKI Yasuaki

Diagnostic Imaging(Additional Post)OOTA Kiyotaka

Radiation Therapy

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging.
KITADATE Masataka Diagnostic Imaging,
DOAI Mariko

Diagnostic Imaging,

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

H.Yokota, H.Tonami: Experimental studies on the bone metabolism of male rats chronically exposed to cadmium
intoxication using dual-energy X-ray absorptiometry, Toxicol. Ind. Health., 24:161-170, 2008.

0400B002

T.Kondo: Experimental study on the evaluation of early therapeutic effect after irradiation using high-resolution
MRI and 1H-MRS, J. Kanazawa. Med. Univ., 33:129-138, 2008 (in Japanese) .

Reviews
0400C001

Y.Ueda, M.Shimasaki, K.Higashi, G.Guo, K.Sato, M.Sagawa, T.Sakuma, S.Katsuda: Recent advance in thepathology of lung cancer, J. Kanazawa. Med. Univ., 33:21-30, 2008 (in Japanese) .

－ 61 －

Presentations at Conference
International Conference (Presentations)
0400I001

Y.Kuginuki, H.Tonami: Computational flow dynamics in abdominal aortic aneurysm using multislice CT, RSNA 94th
Scientific assembly and annual meeting, (Chicago, '08.11).

－ 62 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

AKITA Toshiaki

Cardiovascular surgery

SHIKATA Hiroo

Vascular surgery

HIDA Kenji

Vascular surgery

NAGAYOSHI Yasuhiro Cardiovascular surgery
NISHIZAWA Hisateru Cardiovascular surgery
KANNO Masaaki

Cardiovascular surgery

KOBATA Takashi

Vascular surgery

HASEGAWA Hiroki

Cardiovascular surgery

NONAKA Toshimichi

Cardiovascular surgery

NOGUCHI Yasuhisa

Cardiovascular surgery

KIYOSAWA Jun

Cardiovascular surgery

MIZUNO Fumito

Cardiovascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Publications
Originals
0410B001

K.I.Takeuchi, S.Sakamoto, Y.Nagayoshi, H.Nishizawa, Y.Noguchi, J.Kiyosawa, J.Matsubara: Change in serum S100β after cardiovascular surgery, Estratto da CHIRURGIA., 21:135-138, 2008.

Reviews
0410C001(T.Nishibe), Y.Kondo, M.Ando, N.Shiiya, A.Ishida, T.Miyata, Y.Obitsu, H.Shigematsu, S.Shindo, K.Hida,
J.Matsubara, T.Ohta, T.Kawasaki, T.Yasugi, T.Onohara: Current status of antiplatelet drug treatment for patientswith ASO in Japan, The journal of Japanese College of Angiology., 48：67-73, 2008 (in Japanese) .

Case Reports－ 63 －

0410D001

H.Shikata, M.Kohno, M.Kanno, J.Matsubara: A case of endoscopic surgery in an octogenearian for large
esophageal hernia oppressing the lung and heart, The Journal of the Japanese Association for Chest Surgery., 22：649-653, 2008 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0410H001

K.Hida, Y.Noguchi, T.Kobata, H.Shikata, T.Akita: Evaluation of the short-term results of endovenousradiofrequency obliteration of the saphenous vein using ultrasound echography and air plethysmograhy, The 5th
Meeting of the Japanese-German Society for Vascular Surgery, (Toba, '08.08).

－ 64 －

0420

Department of Surgical Oncology

Name

Field of Specialization

TAKASHIMA Shigeki

Surgical treatment of gastrointestinal cancer-especially gastric cancer
and colorectal cancer

KOSAKA Takeo

Surgical treatment of gastric cancer

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

NAKANO Yasuharu

Surgery of breast cancer

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Faculty
Title

YOSHITANI Shinichiro Surgery of colorectal cancer
TANAKA Yumiko

Surgery of colorectal cancer

HASEGAWA Taisuke Surgery of hepatobiliary diseases
MUKAI Hirokado

Surgery of digestive disease

YOKOI Miki

Surgery of breast cancer

KURODA Masatoshi

Surgery of colorectal cancer

HAYASHI Kei

Surgery of digestive disease

OOBA Masaru

Surgery of gastric cancer, Surgery of colorectal cancer

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research・ A treatment strategy for advanced pancreato-biliary cancer, based on the pattern of tumor invasion
・ Investigation concerning laparoscopic surgical procedure for safe and secure operation, and its establishment.
・ Study of generalization and standardization for laparoscopic surgery in the gastrointestinal disease.
・ Study of safeness in the laparoscopic surgery for malignant disease and functional preserving laparoscopic operation.
・ Study on the education and training for laparoscopic surgery.
・ Introduction of the recently evolving engineering and robotics to laparoscopic surgery.

－ 65 －

0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

MATSUMOTO Tadami Hip surgery(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

FUJITA Takuya

Spinal surgery

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

OKUDA Tetsuhito

Spinal surgery

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

MAEOKA Hayato

TraumaHOSOKAWA Hidetaka Spinal surgery
ICHISEKI Toru

Hip surgery

HATANO Eiju

Spinal surgery

MIAKI Kohei

Hip surgery

HIROMURA Kentaro

TraumaFUKUI Kiyokazu

Hip surgery

YASUDA Yoshihito

Spinal surgery

YAMADA Kengo

Hip surgery

KITAMURA Kenji

Hip surgery

TAKADA Naruki

TraumaTOMIDOKORO Jun

Hip Surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we have been trying to elucidate the mechanism of degeneration of lumber disc. It has been reported that
apoptosis of vertebral disc cells occurs in the degenerative intervertebral disc. However, its molecular mechanism remains
to be defined. The gene expression of Bax and Bcl-2 was analyzed in degenerative intervertebral disc. As a result,mechanical stress of the disc induces apoptosis through a Bax, reducing the number of cells and the synthesis ofextracelular matrix proteins and resulting in the degeneration of the disc.

－ 66 －

Publications
Originals
0430B001(H.Kimura), A.Kaneuji, T.Sugimori, T.Matsumoto: Revision total hip arthroplasty by nonmodular short and longcementless stems, J. Orthop. Sci., 13:335-340, 2008.

0430B002(T.Kabata), T.Matsumoto, S.Yagishita, T.Wakayama, S. Iseki, K.Tomita: Vascular endothelial growth factor in
rabbits during development of corticosteroid-induced osteonecrosis: a controlled experiment, J. Rheumatol.,
35:2383-2390, 2008.

0430B003(K.Hirosaki), K.Shintani, A.Kaneuji: Development of custom-made design method of artificial hip joint stem,
Journal of the Japan Society of Precision Engineering., 74:313-318, 2008 (in Japanese) .

0430B005(H.Matsuzaki), M.Iwasaki, H.Sato, K.Sato, T.Fujita: A clinical evaluation in 4 different hospitals for the pedicle
screw fixation with hydroxyapatite granules (HA stick), Med. Postgrad., 46:209-215, 2008 (in Japanese) .

0430B009(K.Shintani), K.Matsunaga, A.Kaneuji: A study of the insert position of the acetabular shell in total hip
arthroplasty. ―Effect of elevated or medial hip center on stress distribution in the pelvis―, Nippon rinsho
Japanese Journal of Clinical Biomechanics., 29:331-336, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0430I001

T.Fujita, T.Okuda, H.Hosokawa, Y.Yasuda, T.Matsumoto: Postoperative change of the cross-sectional area of themultifidus muscle after percutaneous pedicle screw fixation, The International Society for the Study of the Lumbar
Spine (ISSLS), Spineweek 2008, (Geneva, '08.05).

0430I002

A.Kobe, M.Minamizuka, K.Kuriiwa, J.Kiyoi, T.Muratani, M.Oda, M.Yamaguchi, A.Kaneuji, T.Matsumoto: Control
in Motor units on gluteus medius muscles of hip osteoarthritic persons withD-T sign during free walking., 10th
International Congress of the Asian Confederation for Physical Therapy, (Chiba, '08.08)，10th International
Congress of the Asian Confederation for Physical Therapy Program & Abstract, 90, 2008.

0430I003

T.Okuda, T.Fujita, A.Kaneuji, K.Miaki, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: Influences ofosteoarthritis of the hip joint on the lumbar spine, The 18th Japanese-Korean Combined Orthopaedic Symposium(JKCOS 2008), (Nagasaki, '08.08).

－ 67 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of SpecializationIIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

TAKADA Hisashi

crebrovascular disease, head injury, interventional neurosurgery

IIDA Takaaki

spinal disease, peripheral nerve disease

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

SASAGAWA Yasuo

brain tumor

SIRAGA Syunsuke

general neurosurgery

MURASAKA Kenshi

general neurosurgery

YAMAMOTO Kenji

general neurosurgery

YAMAMOTO Jiro

general neurosurgery

TORIGOE Keiichiro

general neurosurgery

SAKAI Sotaro

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia－ 68 －

4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001

T.Akai, S.Siraga, Y.Sasagawa, K.Okamoto, O.Tachibana, H.Iizuka: Intra-Parenchymal tumor biopsy using
neuroendoscopy with navigation, Minim Invasive Neurosurg, 51:83-86, 2008.

Reviews
0440C001

H.Iizuka, T.Iida: Surgical management of non-traumatic atlantoaxial dislocation, Japanese journal of neurosurgery.,
17：317-321, 2008 (in Japanese) .

Case Reports
0440D001

Y.Sasagawa, T.Akai, T.Sasaki, H.Iizuka: Chiasmal and/or optic-nerve apoplexy due to rupture of vascularmalformation －Case Report－, Neurol. Med. Chir. (Tokyo), 48:460-465, 2008.

－ 69 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery
SHIMADA Kenichi

Plastic and Reconstructive Surgery

KISHIBE Miyuki

Plastic and Reconstructive Surgery

YAMAMOTO Yasunori Plastic and Reconstructive Surgery
YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

KUROSAWA Tomoko Plastic and Reconstructive Surgery
HIMI Yuji

Plastic and Reconstructive Surgery

SHINOKAWA Yasuo

Plastic and Reconstructive Surgery

HARASHIMA Youto

Plastic and Reconstructive Surgery

MORITA Reiji

Plastic and Reconstructive Surgery

MIYASHITA Matsuki

Plastic and Reconstructive Surgery

OKAMURA Ai

Plastic and Reconstructive Surgery

NAKAMURA Namiki

Plastic and Reconstructive Surgery

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

Publications
Originals－ 70 －

0450B001

R.Satsuki, N.Nakabayashi, S.Kawakami: Characteristics of inpatients with burns at fukui prefectural hospital over 6
years, Japanese journal of burn injuries., 34：23-31, 2008 (in Japanese) .

0450B002

T.Miyanaga: Degradation and absorption process of injected hyaluronic acid into subcutaneous tissue, J.
Kanazawa. Med. Univ., 33:117-128, 2008 (in Japanese) .

Reviews
0450C007

K.Shimada, S.Kawakami: Surgical management for trochanteric and iliac pressure sores, The Japanese journal ofplastic & reconstructive surgery., 51：1153-1161, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0450I001

H.Daizo, R.Morita, S.Kawakami: The treatment of orbital medial wall fracture using a navigation system, The 18th
Japan-China Joint Meeting on Plastic Surgery, (Xi'an, Shaanxi, China, '08.09).

0450I002

R.Sakurai, M.Kishibe, S.Kawakami: Reconstruction of the contracted finger deformity due to a lineal volar scarusing subcutaneous pedicle flaps of the remained volar and mid lateral normal, The 18th Japan-China Joint Meetingon Plastic Surgery, (Xi'an, Shaanxi, China, '08.09).

0450I003

N.Koizumi, M.Kishibe, S.Kawakami: Proliferative and differentiative effects of bFGF on elastic cartilage, The 18th
Japan-China Joint Meeting on Plastic Surgery, (Xi'an, Shaanxi, China, '08.09).

0450I004

Y.Yamamoto, S.Kawakami, N.Nakamura: Cowden disease accompanied with unilateral breast hypertrophy, The
18th Japan-China Joint Meeting on Plastic Surgery, (Xi'an, Shaanxi, China, '08.09).

0450I005

A.Nishio, S.Kawakami: Primary Repair of Bilateral Cleft Lip using Dehaan’s Method, The 18th Japan-China Joint
Meeting on Plastic Surgery, (Xi'an, Shaanxi, China, '08.09).

－ 71 －

0460

Department of Pediatric Surgery

Name

Field of Specialization

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

KONUMA Kunio

Pediatric surgery, Anorectal malformations, Pediatric laringo tracheo
surgery

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Faculty
Title

FUKUMOTO Hironori Pediatric surgery
OGAWA Eri

Pediatric surgery

OSHIKIRI Takahiro

Pediatric surgery

TAKAHASHI
Sadayoshi

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

K.Konuma, H.Ikawa, M.Kohno, H.Masuyama, H.Fukumoto, E.Ogawa, T.Oshikiri: A psychological backgroundstudy of patients with encopresis, Japanese journal of pediatric surgery ; Shoni geka., 40:149-158, 2008 (inJapanese) .

Case Reports
0460D001

H.Shikata, M.Kohno, M.Kanno, J.Matsubara: A case of endoscopic surgery in an octogenearian for large
esophageal hernia oppressing the lung and heart, The Journal of the Japanese Association for Chest Surgery., 22：649-653, 2008 (in Japanese) .

0460D002

M.Kohno, S.Takahashi, T.Oshikiri, E.Ogawa, H.Fukumoto, H.Masuyama, K.Konuma, H.Ikawa: Cystic
lymphangioma of the round ligament of the liver in a child, Journal of the Japanese Society of Pediatric Surgery.,
44:981-984, 2008 (in Japanese) .

－ 72 －

Presentations at Conference
International Conference (Presentations)
0460I001

M.Kohno, H.Ikawa, K.Konuma, H.Masuyama, H.Fukumoto, E.Ogawa, T.Oshikiri：Laparoscopic retroperitoneal
approaches for nephrectomy in shildren，11th World Congree of Endoscopic Surgery，（Yokohama，’08.09）．

0460I002

E.Ogawa, T.Oshikiri, H.Fukumoto, H.Masuyama, K.Konuma, M.Kohno, H.Ikawa：Elective laparoscopic resection
for intestinal duplication at the radix mesenterii with repeated per-forations in a shild，11th World congress ofendoscopic surgery，（Yokohama，’08.09）．

－ 73 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

SASAKI Hiroshi

cataract, epidemiology, uveitis.

NAKAIZUMI Hiroko
KITAGAWA Kazuko(Additional Post)

KOJIMA Masami

intraocular lens, strabismus amblyopia, blepharospasm, pediatric
ophthalmology.
ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics.
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration.

NAGAI Kouta

cataract, epidemiology,

KAWAKAMI Yutaka

cataract, thyroid ocular.

FUJITA Nobuyuki

uveitisHAGIWARA Kenta

ocular infection

INAGAKI Shinsuke

ocular infection

NAKANO Tarou

cataract

YAGUCHI Hiromoto

corneal epithelium, glsucoma.

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 74 －

Publications
Originals
0470B001(R.P.Kowalski), E.G.Romanowski, F.S.Mah, H.Sasaki, M.Fukuda, Y.J.Gordpm: A comparison of moxifloxacin andlevofloxacin topical prophylaxis in a fluoroquinolone-resistant staphylococcus aureus rabbit model, Jpn. J.
Ophthalmol., 52:211-216, 2008.

0470B002(A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki: Computation of temperature elevation in rabbit
eye irradiated by 2.45-GHz microwaves with different field configurations, Health Phys., 92:134-144, 2008.

0470B003(A.Hirata), H.Sugiyama, M.Kojima, H.Kawai, Y.Yamashiro, O.Fujiwara, S.Watanabe, K.Sasaki: Computationalmodel for calculating body-core temperature elevation in rabbits due to whole-body exposure at 2.45 GHz, Phys.
Med. Biol., 53:3391-3404, 2008.

0470B004

M.Fukuda, H.Sasaki: Calculation of AQCmax:comparison of five ophthalmic fluoroquinolone solution, Curr. Med.
Res. Opin., 24:3479-3486, 2008.

0470B005

M.Fukuda, J.Takahashi, Y.Nishida, H.Sasaki: Intraocular penetration of astaxanthin in rabbit eyes, Journal of theeye., 25:1461-1464, 2008 (in Japanese) .

Reviews
0470C001(GW.Laurie), LA.Olsakovsky, BP.Conway, RL.Mckown, K.Kitagawa, JJ.Nichols: Dry eye and designer ophthalmics,
Optom. Vis. Sci., 85:643-652, 2008.

Others
0470F001

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, A.Hirata, Y.Sakamoto, Y.Kawakami, S.Watanabe, K.Wake, M.Taki,
Y.Kamimura, H.Sasaki, K.Sasaki: Investigation of wavelength-specific characteristics of quasi- and millimeterwaves, URSI, KP214:1-4, 2008.

Presentations at Conference
International Conference (Presentations)
0470I001

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, Y.Sakamoto, Y.Kawakami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of millimeter wave exposure through ocular temperature measurement andheat transportation, Association for Research in vision and Ophthalmology, (Florida, '08.04).

0470I002

H.Sasaki, N.Yamamoto, Y.Takashima, T.Yamaguchi, E.Shibuya, Y.Inomata, Y.Sakamoto, Y.Kawakami,
H.Nakaizumi, K.Sasaki: Higher-order aberrations in transparent crystalline lens japanese eye, Association for
Research in Vision and Ophthlalmology, (Florlda, '08.04).

0470I003

N.Fujita, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, N.Yamamoto, Y.Kawakami, K.Nagai, H.Nakaizumi, K.Sasaki:
Comparison of myopia induced by retrodots and nuclear cataract, Associatin for Research in Vision andOphthalmology, (Florida, '08.04).

0470I004

M.Fukuda, H.Sasaki, N.Takahashi, M.Yoshikawa, M.Kojima, K.Kitagawa, Y.Sakamoto, K.Sasaki: Development oftechnique to measure corneal resistance that can be used to evaluate corneal injury, Association for Research in
Vision and Ophthlalmology, (Florida, '08.04).

0470I005

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Protective effect of topical
5-S-GAD on UV-B- induced cataract in rats, Association for Research in Vision and Ophthalmology, (Florida,'08.04).

0470I006

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.lu, J.Zhang, K.Sasaki: Prevalence of pseudoexfoliation inchina, Association for Research in Vision and Ophthalmology, (Florida, '08.04).

－ 75 －

0470I007

J.Qu, H.Sasaki, Y.Sakamoto, H.Nakaizumi, Y.Kawakami, K.Nagai, K.Sasaki: Influcence of capsular capture of
intraocular lens on ocular higher- order wavefront aberration, Association for Research in Vision andOphthalmology, (Florida, '08.04).

0470I008

Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, Y.Kawakami, J.Qu, K.Sasaki, H.Sasaki: Does corneal curvatureradius contribute to pathogenesis of pterygium? -A report from chinese ophtalmic surveys in Hainan and Shanxi,
Association for Research in Vision and Ophthalmology, (Florida, '08.04).

0470I009

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada,S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki,
K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara: Proposal for A new clinicalentity, IGG4-Positive Multi-Organ Lymphoproliferative syndrome : analysis of 64 cases of IGG4-Relateddisorders., 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

0470I010

M.Kojima, T.Sakai, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, Y.Kawanami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of Quasi and millimeter wave exposure through ocular temperature
measurement and heat transportation, The Bioelectromagnetics in Society 30th Annual Meeting, (San Diego,'08.06).

0470I011

N.Tomosugi, K.Kitagawa, H.Tsuchida, H.Umehara: Identification and quantification of tear proteins in sjogren's,
HUPO 2008 'th WORLO CONGRESS, (Amsterdam, '08.08).

0470I012

H.Osada, Y.Yamashiro, R.Honda, Y.Sakamoto, K.Nagai, Y.Kawakami, K.Sasaki, H.Sasaki: Posterior capsule
opacifiation in rural areas of China, The 7ｔｈ Asian Cataract Research Conference in Conjunction with Cataract
Satellite Meeting of the 18th International conference for Eye Research and the 11th Conference of Chinese
Cataract Society, (Xi'an, '08.09).

0470I013

H.Sasaki: High order aberration of phakic and pseudophakic eyes, The 7th Asian Cataract Research
Conference in Conjunction with Cataract Satelite Meeting of the 18th International Cngerence for Eye
Research and the 11th Conference of Chinaese Cataract Society Clincal Warkshop, (Xi'an, '08.09).

0470I014

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: Effect factors oflens thickness, The 7th Asian Cataract Research Conference in Conjunction with Cataract Satellite Meeting of the
18th international Conference for Eye Research and the 11th Conference of Chinese Cataract Society Clinical
Warkshop, (Xi'an, '08.09).

0470I015

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract, The 7th Asina Cataract Research Conference in Conjunction with Cataract satellite Meeting of the 18th
International Conference for Eye Research and the 11th Conference of Chinese Cataract Society, (Xi'an, '08.09).

0470I016

M.Fukuda, H.Sasaki: Vitreous and aqueous penetration of orally and topically administered moxifiloxacin,
International Society of Ocular Toxiology 11th Congress ISOT 2008, (September, '08.09).

0470I017

Y.Sakamoto, H.Sasaki, E.Shibuya, N.Yamamoto, Y.Inomata, M.Tarura, K.Sasaki: Visible light abeorption band ofspectacle lesn and contrast sensitivity function, The 7th Asian Cataract Research Conference in Conjunction with
Cataract Stellite Meeting of the 18th International Conference for Eye Research and the 11th Conference ofChinese Cataract Society, (Xi'an, '08.09).

0470I018(T.Daniels), K.Kitagawa, H.Tsuchida, H.Umehara: -SICCA- International sjogren's syndrome registry : Two Yearfollow-up analyses and elucidation of fow keratoconjunctivitis sicca subtypes, ACR/ARHP 08, (San Francisco,'08.10).

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0480

Department of Otolaryngology

Faculty
Title

Name
TOMODA Koichi
SUZUKA Yuko

Field of Specialization
Otology, Computer aided surgery, Head and Neck surgery,
Neuroimmunology
Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

MURATA Hideyuki

Rhinology, Head and neck surgery, Endoscopic surgery, Computer
aided surgery

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

HORIGUTI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

ISHIMASA Hiroshi

Head and neck surgery, rhinology, General otolaryngology

IWASAKI Noriko

Head and neck oncology, Immune-allergic disease, generalotolaryngology

NAKAIZUMI Toshihiko Otology, Clinical andbasic otology research
MIYAZAWA Toru

Basic otology research, Head and neck surgery

KITAMURA Miwa

Otolaryngology

SAKAI Aya

Sleep apnea, Otolaryngology

YAMADA Kanako

Audiology, Otolaryngology

YAMAMOTO Junpei

Otorhinolaryngology

Keywords of Researchneurotology, otoneuro surgery, tympanoplasty, vestibular neurectomy, cochlear implant, middle ear implant, virtual
endoscopy, computer-aided surgery, endoscopic nasal surgery, laser surgery, sleep apnea & snoar surgery, skull base
surgery, head and neck tumor surgery, molecular biology, neuroimmunology, oncology, laryngology, speech rehabilitation,
acoustic neuroma surgery, navigation surgery, tele-medicine, thyroid tumor surgery, virtual education for surgery

Outline of Research
Research for 3D mobile navigation system
Central mechanism of auduological function by MEG
Restration for phonation with Provox 2 prosthesis
Clinical reserach for snoar and sleep apnea
Research for Thyroid and parathyroid gland
Inner ear molecular biology
Clinical survey for Head and Neck tumor and Oncology

Publications
Originals
0480B001(M.Izumikawa), SA.Batts, T.Miyazawa, DL.Swiderski, Y.Raphael: Response of the flat cochlear epithelium to forced
expression of Atoh1, Hear. Res., 240:52-56, 2008.

－ 77 －

0480B002

J.Yamamoto, Y.Shimode, T.Miyazawa, N.Yang, A.Sakai, K.Yamada, K.Tomoda, H.Takahashi: The pollen count ofcryptomeria japonica and its relation to the direction of wind in Uchinada(2007), Pollen allergy and prevention.,
19:20-27, 2008 (in Japanese) .
0480B004(T.Inoue), M.Nagata, H.Yukawa, M.Ogura, M.Yagi, T.Fujisawa, M.Miyamoto, S.Chikano, H.Takemura,
T.Yamashita, H.Tsuji: Pathological study on preoperative concurrent chemoradiation for advanced hypopharyngeal
cancer, Head and neck cancer., 34：544-547, 2008 (in Japanese) .

0480B005(T.Wada), Y.Suzuka, J.Inokuchi, S.Ooki, S.Ohyama, Y.Okamoto, S.Sugihara, H.Torii, K.Makishima, K.Murai,
H.Zusho, A.Hara, S.Komune, S.Shida: Noise at the work place and noise-induced hearing loss in the Japaneseindustry, especially in small-sized companied with less than 50 employees, Audiol Jpn, 51：1-7, 2008 (inJapanese) .

0480B006

T.Miyazawa, H.Murata, Y.Shimode, Y.Suzuka, K.Tomoda: Timing for emergent air way preservation of acuteepiglottitis adults, Journal of Japan Society for Infectious Diseases in Otolaryngology., 26：125-129, 2008 (inJapanese) .

Case Reports
0480D001

K.Sato, Y.Shimode, M.Hirokawa, Y.Ueda, S.Katsuda: Thyroid adenomatous nodule with bizarre nuclei: a casereport and mutation analysis of the p53 gene, Pathol. Res. Pract., 204:191-195, 2008.

Others0480F001

Y.Suzuka, M.Higuchi, N.Hatsusaka, H.Kado: Mechanism of illusory motion in the “Rotating Snakes” illusionary
image:an MEG study, Proceedings of the 13th International Conference on Biomagnetism, 115-117, 2008.

Presentations at Conference
International Conference (Synposium)
0480H001

K.Tomoda, H.Murata, Y.Suzuka, J.Yamamoto: Current status of image-guided surgery in
Otorhinolaryngology,Japan, Computer Assisted Radiology and Surgery (CARS) 2008, (Barcelona, '08.06)，Int J
CARS, 3 (Suppl 1): 84-85, 2008.

International Conference (Presentations)
0480I001

K.Tomoda, H.Murata: Current status of image-guided surgery in Otorhinolaryngology, Japan, 27th International
Symposium of Infection & Allergy of the Nose (ISHIAN), (Crete, Greece, '08.06).

0480I002

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada,S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki,
K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara: Proposal for A new clinicalentity, IGG4-Positive Multi-Organ Lymphoproliferative syndrome : analysis of 64 cases of IGG4-Relateddisorders., 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

0480I003

Y.Suzuka: Mechanism of illusory motion in the "Rotating Snakes" illusionary image: an MEG study, The 26th
Internaional Conference on Biomagnetism, (Sapporo, '08.08)，The 26th Internaional Conference on Biomagnetism
proceeding, 26:117, 2008.

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0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

MOCHIZUKI Takashi Medical mycology ， Dermatomycosis
TANABE Hiroshi

Medical mycology, Decubitns

WATANABE Seiji

Medical mycology

KAWASAKI Masako

Medical mycology

ABE Shinya

Skin tumor and growth factores

FUJII Toshiki

Dermatopathology

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

TAKEDA Kiminobu

Medical mycology

TACHIKAWA
Nobuyuki
WAKAMATSU
Nobuhiko

Medical mycology
Dermatopathology

FUJITA Jun

Medical mycology

HASEI Maki

Skin tumor and growth factores，Medical mycology

OGAWA Haruko

Dermatopathology

TERADA Maiko

Dermatopathology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartyping, electron microscopy, dermatopathology, skin tumor, decubitus, deep tissue injury

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

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Publications
Originals
0490B001

M.Kawasaki, K.Anzawa, K.Takeda, H.Tanabe, T.Mochizuki, H.Ishizaki: Ｇｅｎｅｔｉｃ ａｎｄ ｐｈｅｎｏｔｙｐｉｃ ｖａｒｉａｔｉｏｎｓ
ａｍｏｎｇ F1 ｐｒｏｇｅｎｉｅｓ ｏｆ Ａｒｔｈｒｏｄｅｒｍａ ｂｅｎｈａｍｉａｅ, Jpn. J. Med. Mycol., 49：103-110, 2008.

0490B002

M.Kawasaki, K.Anzawa, A.Wakasa, K.Takeda, H.Tanabe, T.Mochizuki, H.Ishizaki, BM. Hemashettar: Different
genes can result in different phylogenetic relationships in Trichophyton species, Jpn. J. Med. Mycol., 49：311-318,
2008.

0490B003(H.Shinoda), K.Nishimoto, T.Mochizuki: Screening Examination of Trichonphyton tonsurans among Judo
Practitioners at the All Japan Inter High School Champioships, Saga 2007, Jpn. J. Med. Mycol., 49：305-309, 2008
(in Japanese) .

Reviews
0490C001

T.Mochizuki: The university network of education and technical support of treatment of fungal diseases fordermatologists, Jpn. J. Med. Mycol., 49：181-185, 2008 (in Japanese) .

0490C002

T.Mochizuki: Mycological tests, Nipponrinsho., 66：2319-2325, 2008 (in Japanese) .

Case Reports
0490D001(S.Ohno), H.Tanabe, M.Kawasaki, Y. Horiguchi: Tinea corporis with acute inflammation caused by Trichophyton

tonsurans, J. Dermatol., 35：590-593, 2008.
0490D003

A.Nagaishi, H.Tanabe, M.Ueno, M.Mtsui, M.Matsui: A case of non-alcoholic pellagra following gastrectomy,
Clinical Neurology., 48：202-204, 2008 (in Japanese) .

0490D004

M.Terada, M.Hasei, S.Watanabe, T.Fujii, H.Tanabe, T.Mochizuki: A case of gefitinib (Iressa®）-induced eruption
with acantholysis, Skin research., 7：131-136, 2008 (in Japanese) .

0490D007

K.Takeda, T.Ushigami, J.Fujita, H.Tanabe, T.Mochizuki, T.Machi: A case of penis tuberculid with induratio penis
plastica, Skin research., 7：676-680, 2008 (in Japanese) .

0490D011(N.Umemoto), T.Demitsu, K.Sasaki, M.Kakurai, M.Hayashi, Y.Wada, M.Moriguchi, Y.Hiratsuka, E.Iida, R.Azuma,
M.Kawasaki, T.Mochizuki: Phaeohyphomycosis due to Exophiala jeanselmei in immunocompromised hosts - Reportof two cases, Jichi Medical School journal., 31：77-83, 2008 (in Japanese) .

Short Communications
0490E001

T.Mochizuki, M.Kawasaki, K.Anzawa, J.Fujita, T.Ushigami, K.Takeda, Ａ.Sano, Y.Takahashi, K.Kamei:
Epidemiology of sporadic (non-epidemic) cases of Trichophyton tonsurans infection in Japan based on PCR-RFLP
analysis of non-transcribed spaser region of ribosomal RNA gene, Jpn.J.Infect.Dis., 61：219-222, 2008.

Presentations at Conference
International Conference (Key Note Lecture)
0490G001

T.Mochizuki, K.Anzawa: Molecular diagnosis of superficial mycoses, 8th Asian Dermatological Congress, (Seoul,
Korea, '08.10).

International Conference (Synposium)
0490H001

T.Mochizuki: Molecular epidemiology of cutaneous fungal infection in Japan, 4th Congress of Asia Pacific Society
for Medical Mycology, (Seoul, Korea, '08.10).

－ 80 －

0500

Department of Urogenital Surgery

Name

Field of Specialization

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

TANAKA Tatsuro

kidney transplantation, endourology

Faculty
Title

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer
KAWAMURA Kenjikidney stone disease, urogenital cancer

MORIYAMA Manabu

kidney transplantation， kidney stone disease

SUGA Koudai

general urology

CHIKAZAWA Ippei

general urology

TOKUNAGA Kousuke general urology
TACHIBANA
Hiromichi

general urology

ISHII Takeo

general urology

MORITA Nobuyo

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Case Reports
0500D001

K.Sato, Y.Ueda, H.Tachibana, K.Miyazawa, I.Chikazawa, S.Kaji, T.Nojima, S.Katsuda: Malignant epithelioid
angiomyolipoma of the kidney in a patient with tuberous sclerosis: An autopsy case report with p53 gene mutation
analysis., Pathol. Res. Pract., 204:771-777, 2008.

Presentations at Conference
International Conference (Presentations)
0500I001

K.Miyazawa: The role of cyclooxygenase 2 and prostaglandin e2 in the attachment of calcium oxalate crystals torenal epithelial cells, 11th International Symposium on Urolithiasis, (Nice, '08.09).

－ 81 －

0500I002

M.Moriyama, K.Suga, K.Miyazawa, T.Tanaka, M.Higashioka, K.Noda, M.Oka, M.Tanaka, K.Suzuki: Effects of an
extract of Quercus salicina Blume/Q. stenophylla Makino on urinary stone formation in a rat calcium oxalate
urolithiasis model, 11th International Symposium on Urolithiasis, (Nice, '08.09).

－ 82 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

MAKINODA Satoru

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines

FUJII Ryota

perinatal medicine, reproductive endocrinology

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

TAKAGI Hiroaki

perinatal medicine, reproductive medicine

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

FUJITA Satoko

perinatal medicine, reproductive medicine

INOUE Hirokazu

perinatal medicine, perinatal diagnosis

SASAKURA Chihaya

perinatal medicine, perinatal diagnosis

OKA Yasuko

perinatal medicine, reproductive medicine

KUWAHARA Takashi perinatal medicine
NEYATANI Natsuko

perinatal medicine, climacteric medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

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Publications
Originals
0510B001

S.Makinoda, N.Hirosaki, T.Wasada, H.Tomizawa, R.Fujii: Granulocyte colony-stimulating factor (G-CSF) in themechanism of human ovulation and its clinical usefulness, Curr. Med. Chem., 15:604-613, 2008.

Case Reports
0510D001

J.Moriya, J.Yamakawa, R.Chen, H.Takagi, S.Makinoda, T.Takahashi, T.Kanda: A large ovarian tumor mimicking
the accumulation of ascites, J. Kanazawa. Med. Univ., 33:31-32, 2008.

Presentations at Conference
International Conference (Key Note Lecture)
0510G001

S.Makinoda, H.Tomizawa, S.Fujita, T.Waseda, R.Fujii, T.Utsunomiya: A new application of granulocyte colonystimulating factor (G-CSF) in the female reproductive medicine - For prevention of luteinized unruptured follicle(LUF) -, 2nd World Conference on Magic Bullets(EHRLICH II), (Nuremberg, '08.10).

International Conference (Presentations)
0510I001

S.Makinoda: Luteinzed unruptured follicle (LUF) can be prevented by granulocyte colony-stimulating factor (GCSF), The 13th World Congress of Gynecological Endocrinology, (Florence, '08.03).

0510I002

H.Inoue, S.Makinoda, T.Waseda: Analysis of the hemodynamics of fetal renal artery and fetal renal volume during
the normal course of pregnancy, The 18th World Congress of Ultrasound in Obstetrics and Gynecology, (Chicago,'08.08)，Ultrasound in Obstetrics and Gynecology, 32:357.

0510I003

T.Waseda, H.Inoue, S.Makinoda: Myometrial blood flow analysis in pregnant women with IUGR, The 18th World
Congress of Ultrasound in Obstetrics and Gynecology, (Chicago, '08.08)，Ultrasound in Obstetrics andGynecology, 32:437.

0510I004

T.Wasedas, H.Inoue, H.Tomizawa, S.Makinoda: Three patients suspected of malignant formation of mature cystic
teratoma, 12th Meeting of International Gynecologic Cancer Society, (Bangkok, '08.10).

－ 84 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

TSUCHIDA Hideaki

Cardiovascular Effects of Anesthetics, Intravenous Anesthetics

SEKI Sumihiko

Vascular Reactivity and Cellular calcium dynamics

SHIRAISHI Miharu

Cardiac Anesthesia, Cardiovascular Agents

KARASAWA Noriyuki Ａｎａｐｈｙｌａｘｉｓ
SHIMO Tomohiro

Anaphylaxis

NISHIIKE Satoshi

Cardiovascular effects of anesthetics, Volatile anesthetic

SUGIURA Soichiro

Influence of the endothelium in sepsis, Cardiovasucular effects ofultra-short acting β1-selective blocker

HORIUCHI Katsura

General anesthesia, Local anesthesia

KIDA Hiromasa

Anaphylaxis

YAMAOKA Yuko

General anesthesia, Local anesthesia

MAGARA Ayuko

General anesthesia, Local anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, paraquat, sepsis, delayed neuronal death, apoptosis, inducible nitric oxide synthase, brainischemia, epidural blockade, cytochrome P-450, liver mitochondoria, nitric oxide, hypothermia

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined 1) the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole, and 2) the effects of transient forebrain ischemia on
apoptotic death of the hippocampal pyramidal neuron in Mongolian gerbil.

Publications
Case Reports
0520D001

S.Nishiike, M.Shiraishi, N.Karasawa, S.Seki, H.Tsuchida: Is pulmonary artery catheter indicated for transsphenoidal
resection of hypophyseal tumor in patients with acromegalic heart disease? a case report, The Journal of Japan
Society for Clinical Anesthesia., 28:330-333, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0520I001

N.Tomosugi, K.Kitagawa, H.Tsuchida, H.Umehara: Identification and quantification of tear proteins in sjogren's,
HUPO 2008 'th WORLO CONGRESS, (Amsterdam, '08.08).

－ 85 －

0520I002(T.Daniels), K.Kitagawa, H.Tsuchida, H.Umehara: -SICCA- International sjogren's syndrome registry : Two Yearfollow-up analyses and elucidation of fow keratoconjunctivitis sicca subtypes, ACR/ARHP 08, (San Francisco,'08.10).

－ 86 －

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

YOSHMURA Hiroshi

temporomandibular joint disorders, stomatology, neuroscience

DEMURA Noboru

orthodontics, stomatology

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology
NAGAO Toshikazu

temporomandibular joint disorders, stomatology

HONJOU Miho

Orthodontics.

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0530B001(W.Sun), L.Dong, K.Kaneyama, T.Takegami, N.Segami: Bacterial diversity in synovial fluids of patients with TMD
determined by cloning and sequencing analysis of the 16S ribosomal RNA gene, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 105:566-571, 2008.

0530B002

H.Yoshimura, M.Honjo, Y.Mashiyama, K.kaneyama, N.Segami, J.Sato, T.Sugai, N.kato, N.Onoda: Multiple toothlosses during development suppress age-dependent emergence of oscillatory neural activities in the oral
somatosensory cortex., Brain Res., 1224:37-42, 2008.

Reviews
0530C001

K.Kaneyama, N.Segami, T.Hatta: Congenital deformities and developmental abnormalities of the mandibular
condyle in the temporomandibular joint, Congenit. Anom. (Kyoto), 48:118-125, 2008.

－ 87 －

Others
0530F001

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Functional connections between olfactory and gustatory information
via the endopiriform nucleus in the rat., The Japanese journal of taste and smell research., 15:345-346, 2008 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0530I001

N.Segami, W.Sun, K.Kaneyama: Bacterial DNA in synovial fluids of patients with TMD., ⅩⅨCongress of theEuropean Association for Cranio-Maxillo-Facial Surgery, (Bologna, '08.09).

－ 88 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

WATOH Yukihiro

Emergency,Emergency medical syctem,Disaster Medicine,

MASHIBA Satoru

Emergency,Anaphylaxis

HAYASHI Nobuyuki

Emergency,

MORITA Hideki

Emergency,

GOTO Tetsuro

Emergency,

FUKUZUMI Mari

Emergency,

MIZUNUMA Mariko

Emergency,

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

Publications
Others
0550F001

K.Nomura, H.Murai, T.Nakahashi, S.Mashiba, Y.Watoh, T.Takahashi, S.Morimoto: Outbreak of norovirus
gastroenteritis in elderly evacuees after the 2007 Noto peninsula earthquake in Japan, J. Am. Geriatr. Soc.,
56:361-363, 2008.

－ 89 －

0560

Department of Medical Oncology

Name

Field of Specialization

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

NAKAJIMA Hideo

Medical Oncology, Immunology, Molecular Biology

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

NAKAYA Naoki

Medical Oncology

Faculty
Title

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Case Reports
0560D001

J.Moriya, J.Yamakawa, Y.Motoo: Effect of kampo medicine on the long-termadministration of NSAIDs in threecases of gonarthrosis, Pain and kampo medicine., 18：82-87, 2008 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0560H001

Y.Motoo: Intergration of heｒbal medicine into multidisciplinary treatment and holistic care of cancer patients, 2008
Internaional Symposium of East-West Medicine for Cancer Treatment, (Seoul, '08.10).

0560H002

Y.Motoo: Current status of Kampo（Japanese herbal)medicine, 1st Asia Pacific Traditional and Complemantary
Medicine Conference 2008, (Kuala Lumpur，Malaysia, '08.11).

International Conference (Presentations)
0560I001

Y.Motoo: Ｇene expressoin analysis in gemcitabine-treated human pancreatic cancer cells;GSK-3beta as a new
therapeutic target, BIT's Annual WORLD Canser CONGRESS-2008, (Shanghai, China, '08.02).

0560I002(Mai W), A.Shakoori, K.Miyashita, Zhang B, Y.Motoo, K.Kawakami, Y.Takahashi, T.Minamoto: Detection of active
fraction of GSK3beta in cancer cells by non-raioisotopic in vitro kinase assay, AACR Aｎnual Meeting 2008, (San
Diego, CA, USA, '08.04).

－ 90 －

0570

District medical

Faculty
Title

Name

Field of Specialization

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase.

SO Shihei

Cardiovascular distase , Diabetes Mellitus , Mental distase

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda: Brain
atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), Neurochem.
Res., 33:1759-1767, 2008.

0570B002

Z-P.Zong, S.Matsui, J-F.Han, S.Katsuda, ML.Fu: Involvement of thymus in amiodarone-treated autoimmune
myocarditis in rats, Int. J. Cardiol., 125:122-129, 2008.

0570B003(J-l.Wu), S.Matsui, Z-P.Zong, K.Nishikawa, B-G.Sun, S.Katsuda, M.Fu: Amelioration of myocarditis by statin
through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats, J. Mol. Cell. Cardiol.,
44:1023-1031, 2008.

0570B004

F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda: Candesartan
improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, Int. J. Cardiol.,
129:414-421, 2008.

0570B005

K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto:
Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats,
Hypertens. Res., 31:977-986, 2008.

Reviews
0570C001

R.Chen, F.Liang, J.Moriya, J.Yamakawa, T.Takahashi, L.Shen, T.Kanda: Peroxisome proliferator-activatedreceptors(ppars) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?, Int.
J. Cardiol., 130:131-139, 2008.

0570C002

Q.Li, R.Chen, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi: A novel adipocytokine, visceral adipose
tissue-derived serine protease inhibitor(vaspin),and obesity, J. Int. Med. Res., 36:625-629, 2008.

0570C003

R.Chen, FX.Liang, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi: Chronic fatigue syndrome and thecentral nervous system, J. Int. Med. Res., 36:867-874, 2008.

－ 91 －

Case Reports
0570D001

J.Moriya, J.Yamakawa, R.Chen, H.Takagi, S.Makinoda, T.Takahashi, T.Kanda: A large ovarian tumor mimicking
the accumulation of ascites, J. Kanazawa. Med. Univ., 33:31-32, 2008.

Presentations at Conference
International Conference (Presentations)
0570I001

T.Ota, M.Maeda, Z.-P.Zong, M.Murakami, T.Takegami, M.Tatsuka: Phosphorylation and localization of FAK in vSrc transformed fibroblast cells after anoikis induction., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

0570I002

Z.-P.Zong, M.Maeda, M.Murakami, T.Takegami, M.Tatsuka, T.Ota: Effects of oral administration of lapachol on
experimental metastasis of B16 melanoma cells in mice., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

0570I003

T.Kanda, K.Kusaka, T.Takahashi, J.Moriya, J.Yamakawa, R.Chen, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai:
Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute
myocarditis, Basic Cardiovascular Sciences Conference 2008, (Colorado, '08.07).

－ 92 －

0610

Health Management Center

Faculty
Title

Name

Field of Specialization

TAKASE Shujiro

Gastroenterology

MATSUDA Yoshiro

Glossary of Gastroenterology, Hepatology(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine(Additional Post)

YASUDA Yukio

evidence-based health care

(Additional Post)

YAMADA Yuichi

Occupational health, Epidemiology for cardiovascular and pulmonary
diseases(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine(Additional Post)

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

NAKANISHI Yumiko

Preventive medicine

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

KUGINUKI Yasuaki

hemodynamics

KUSAKA Kazuya

Radiologｙ

OOTA Kiyotaka

Radiology

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, "stress, dietary habits", "nutrient intake, exercise"

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0610B001(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial changes in urinary
cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies,
Toxicol. Lett., 176:124-130, 2008.

0610B002(Y.Kamon), T.Okamura, T.Tanaka, A.Hozawa, Z.Yamagata, T.Takebayashi, Y.Kusaka, S.Urano, H.Nakagawa,T.Kadowaki, Y.Miyoshi, H.Yamato, A.Okayama, H.Ueshima, HIPOP-OHP Research Group: Marital Status andCardiovascular Risk Factors among Middleaged Japanese Male Workers: The High-risk and Population Strategy for
Occupational Health Promotion (HIPOP-OHP) Study, J. Occup. Health, 50:348-356, 2008.

0610B003

K.Miura, A.Matumori, A.Nasermoaddeli, Y.Soyama, Y.Morikawa, M.Sakurai, A.Kitabatake, M.Nagai, Y.Inaba,
H.Nakagawa: Prognosis and prongostic factors in patients with idiopathic dilated cardiomyopathy in Japan―resultsfrom a nationwide study―, Circ. J., 72:343-348, 2008.

－ 93 －

0610B004(Y.Hayashino), S.Fukuhara, T.Okamura, H.Yamato, H.Tanaka, T.Tanaka, T.Kadowaki, H.Ueshima, HIPOP-OHP
Research Group, H.Nakagawa, K.Miura: A prospective study of passive smoking and risk of deabetes in a cohort ofworkers:the high-risuk and population strategy for occupational health promotion (HIPOP-OHP) study, Diabetes
Care., 31:732-734, 2008.

0610B005(M.Naito), T.Nakayama, T.Okamura, K.Miura, M.Yanagita, Y.Fujieda, F.Kinoshita, Y.Naito, H.Nakagawa,
T.Tanaka, H.Ueshima, HIPOP-OHP Research Group: Effect of a 4-year workplace-based physical activity
intervention program on the blood lipid profiles of participating employees:the high-risk and population strategy foroccupational health promotion(HIPOP-OHP) study, Atherosclerosis, 197:784-790, 2008.

0610B006(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, M.Nishiho, T.Kido, H.Nakagawa: Estimation of benchmark doses
as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and nonpolluted regions in Japan, Toxicology Lett., 179:108-112, 2008.

0610B007

Y.Morikawa, K.Miura, S.Sasaki, K.Yoshita, S.Yoneyama, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
M.Higashiyama, H.Nakagawa: Evaluation of the effects of shift work on nutrient intake:a cross-sectional study, J.
Occup. Health, 50:270-278, 2008.

0610B008(P.Elliott), H.Kesteloot, LJ.Appel, AR.Dyer, H.Ueshima, Q.Chan, IJ.Brown, L.Zhao, J.Stamler, INTERMAP
Cooperative Research Group, H.Nakagawa, K.Miura: Dietary phosphorus and blood pressure:international study ofmacro-and micro-nutrients and blood pressure, Hypertension, 51:669-675, 2008.

0610B009(Y.Murakami), A.Hozawa, T.Okamura, H.Ueshima, Evidence for Cardiovascular Prevention From Observational
Cohorts in Japan Reserch Group (EPOCH-JAPAN), H.Nakagawa, K.Miura: Relation of blood presssure and allcause mortality in 180 000 Japanese participants:pooled analysis of 13 cohort studies, Hypertension, 51:14831491, 2008.

0610B010

K.Sunaga, K.Miura, Y.Naruse, M.Sakurai, Y.Morikawa, Y.Kurosawa, H.Nakagawa: Glycated hemoglobin and risk ofstroke, ischemic and hemorrhagic, in Japanese men and women, Cerebrovasc. Dis., 26:310-316, 2008.

0610B011

K.Miura, J.Stamler, H.Nakagawa, P.Elliott, H.Ueshima, Q.Chan, IJ.Brown, I.Tzoulaki, S.Saitoh, AR.Dyer,
ML.Daviglus, H.Kesteloot, A.Okayama, JD.Curb, BL.Rodriguez, PJ.Elmer, LM.Steffen, C.Robertson, L.Zhao,
International Study of Macro-Micronutrients and Blood Pressure Reserch Group: Relationship of dietary linoleic
acid to blood pressure:the international study of macro-micronutrients and blood pressure study, Hypertension,
52:408-414, 2008.

0610B012

S.Yoneyama, K.Miura, K.Itai, K.Yoshita, H.Nakagawa, T.Shimmura, A.Okayama, K.Sakata, S.Saitoh, H.Ueshima,
P.Elliott, J.Stamler, INTERMAP Research Group: Dietary intake and urinary excretion of selenium in the Japanese
adult population: the INTERMAP Study Japan, Eur. J. Clin. Nutr., 62:1187-1193, 2008.

0610B013(Japan Arteriosclerosis Longitudinal Study(JALS) Group), H.Nakagawa: Japan arteriosclerosis longitudinal studyexisting cohorts combine(JALS-ECC)-rationale, design, and population characteristics-, Circ. J., 72:1563-1568,
2008.

0610B014(T.Ninomiya), Y.Kiyohara, Y.Tokuda, Y.Doi, H.Arima, A.Harada, Y.Ohashi, H.Ueshima, Japan Arteriosclerosis
Longitudinal Study Group, H.Nakagawa, K.Miura, Y.Morikawa, M.Ishizaki: Impact of kindey disease and bloodpressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal
Study., Circulation, 118:2694-2701, 2008.

0610B015

M.Ishizaki, H.Nakagawa, Y.Morikawa, R.Honda, Y.Yamada, N.Kawakami, The Japan Work Stress and HealthCohort Study Group: Influence of job strain on changes in body mass index and waist circumference-6-year
longitudinal study, Scand. J. Work Environ. Health, 34:288-296, 2008.

0610B016(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

0610B017(H.Ueda), A.Higashiyama, A.Okayama, T.Okamura, N.Okuda, K.Yoshita, S.Saitoh, K.Sakata, SR.Choudhury,
T.Kadowaki, Y.Kita, K.Miura, H.Nakagawa, M.Watanabe, H.Ueshima, INTERMAP Japan Research Group: Obestiyand percentage energy from fat: the INTERMAP study of middle-age Japanese men, Japanese journal of
cardiovascular disease prevention., 43:123-131, 2008 (in Japanese) .

－ 94 －

0610B018(M.Nozue), N.Sarukura, M.Nishijo, H.Fujii, Y.Arai, A.Ishiwaki, N.Yoshiike, H.Nakagawa, K.Yoshita: A study on
seasonal variations in nutrients and food groups and the relation between vegetable consumption andnutrients/food groups in a rural ares of Toyama, Hokuriku Japanese Journal of Public Health., 34:58-64, 2008 (inJapanese) .

0610B019

M.Nakashima, K.Miura, Y.Morikawa, M.Nishijo, Y.Nakanishi, M.Sakurai, H.Nakagawa: Effect of smoke-free medical
school on smoking behavior of medical students, Japanese Journal of Public Health., 55:647-654, 2008 (inJapanese) .

Short Communications
0610E001

M.Nishijo, S.Maruzeni, K.Tawara, T.Kido, Nhu.DD, Naganuma.R, H.Suzuki, Hung.TM, Dung.PT, Thom.LH,
H.Nakagawa: Porychlorinated-dibenzo-p-dioxins/Furans and pregnancy outcome among vietnamese women living
in a herbicide sprayed area, Organohalogen Compounds., 70:1882-1885, 2008.

0610E002(T.Kido), R.Naganuma, H.Suzuki, Nhu.DD, K.Saito, M.Nishijo, H.Nakagawa, K.Tawara, Hung.NN, Thom.LH,
Dung.PT: The relationship between visualacuity and dioxin levels of breast milk in the herbicide sprayed and nonsprayed areas in vietnam, Organohalogen Compounds., 70:550-553, 2008.

Others
0610F001

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H.Nakagawa: BMI may be better than waist circumference for defining
metabolic syndrome in Japanese women, Diabetes Care., 31:e12, 2008.

0610F002

M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase: Successful rituximab
monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of thetransverse colon in a patient with liver cirrhosis, Scand. J. Gastroenterol., 43:761-764, 2008.

0610F003(T.Kido), S.Maruzeni, H.suzuki, Y.Odamae, M.Marunaka, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa,
TM.Hung, LTH.Thom, PT.Dung, DD.Nhu, H.Oka, K.Noguchi: Five years studies on the long term effects of war
ahent orange/dioｘinn on human health in fietnam, 平成 17 年度～平成 19 年度科学研究費補助金(基盤研究(B))
研究成果報告書（研究代表者 城戸照彦）, 1-37, 2008.

0610F010(C.Aoki), M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura,
Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse: Smoking cessation rate and its related
factors on a smoking cessation support program in a workplace, Hokuriku Japanese Journal of Public Health.,
35:36-38, 2008 (in Japanese) .

0610F011(C.Okamoto), M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura,
M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Effects of educational program
under a tutorial or a small-group system on body weight loss for obese participants in a workplace, Hokuriku
Japanese Journal of Public Health., 35:39-41, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0610I001

M.Sakurai, K.Miura, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of long-term body weight change to HDL particle size change in Japanese men and women:The
INTERMAP Toyama study. Joint conference, 49th Cardiovascular Disease Epidemiology and Prevention -andNutrition, (Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

0610I002

K.Miura, M.Sakurai, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of 9-year body weight change to change in LDL particle size in Japanese men and women:The INTERMAP
Toyama study, Joint Conference -49th Cardiovascular Disease Epidemiology and `revention -and- Nurtrition,(Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

－ 95 －

0610I003

T.Kanda, K.Kusaka, T.Takahashi, J.Moriya, J.Yamakawa, R.Chen, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai:
Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute
myocarditis, Basic Cardiovascular Sciences Conference 2008, (Colorado, '08.07).

0610I004

M.Nishijo, S.Maruzeni, K.Tawara, T.Kido, N.DD, R.Naganuma, H.Suzuki, H.TM, D.PT, T.LTHN, H.Nakagawa:Porychlornated-dibenzo-p-dioxins/furans and pregnancy outcome among vietnamesewomen living in a herbbicide
sprayed area, 28th International Symposium on Halogenated Presistent Organic Pollutans (POPs), (Birmingham,'08.08)，LOOKING TO THE FUTURE DEVELOPING THE NEXT GENERATION, 1882-1884, 2008.

0610I005(H.Horikawa), H.Suzuki, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa, H.NN, T.LTH, D.PT, N.DD, V.PT,
B.NT, W.T, T.Kido, Y.Sato: Relation between dioxins levels in human breast milk samples and SCE values amonglactating females in a defoliants-sprayes area in Vietnam, 28th International Symposium on Halogenated Presistent
Organic Pollutans (POPs), (Birmingham, '08.08)，LOOKING TO THE FUTURE:DEVELOPING THE NEXT
GENERATION, 646-648, 2008.

0610I006(T.Kido), R.Naganuma, H.Suzuki, D.D.N, K.Sato, M.Nishijo, H.Nakagawa, K.Tawara, N.N.H, L.H.T, P.T.D.PT:
The relationship between visual acuty and dioxin levels of breast milk in the herbicide sprayed and non-sprayedareas in Vietnam, 28th International Symposium on Halogenated Presistent Organic Pollutans (POPs),(BIRMINGHAM, '08.08)，LOOKING TO THE FUTURE:DEVELOPING THE NEXT GENERATION, 550-552,
2008.

0610I007

Y.Morikawa, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, H.Nakagawa, Y.Naruse, M.Higashiyama: Drinking habit
among shift workers and its health effects, 3rd ICOH International Conference on Psychosocial Factors at work,(Quebec, '08.09)，2008.

0610I008

K.Kitaoka, Y.Morikawa, S.Matsuda, K.Ogino, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Burnout and riskfactors for arteriosclerotic disease: follow-up study, 3rd ICOH International Conference on
Psychosocial Factors at work, (Quebec, '08.09)，2008.

0610I009

Y.Kuginuki, H.Tonami: Computational flow dynamics in abdominal aortic aneurysm using multislice CT, RSNA 94th
Scientific assembly and annual meeting, (Chicago, '08.11).

－ 96 －

0620

Department of Pathology

Faculty
Title

Name

Field of Specialization(Additional Post)

MINATO Hiroshi

Anatomical pathology, Laboratory medicine, Pathological study of
pulmonary and mediastinal lesion, Pathological study of head & necktumor.

(Additional Post)

KUROSE Nozomu

surgical pathology, molecular pathology(Additional Post)KINOSHITA Erikosurgical pathology, molecular pathology

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Outline of Research
1.Anatomical pathology, Laboratory medicine, Pathological study of pulmonary and mediastinal lesion, Pathological study ofhead & neck tumor.
2.cellular pathology.
3.molecular pathology.

Publications
Originals
0620B001(T.Yamaguchi), A.Kawahara, H.Minato, S.Ota, K.Fujiyoshi, K.Ushijima, T.Kamura, M.Kage: Cytological study ofneuroendocrine tumors of the uterine cervix－Differential diagnosis from cervical squamous cell carcinoma andadenocarcinoma－, J. Jpn. Soc. Clin. Cytol., 47:86-94, 2008 (in Japanese) .

0620B002(J.Shimizu), M.Oda, I.Matsumoto, Y.Arano, N.Ishikawa, K.Saitoh, H.Minato: Clinicopathologic study of surgicallytreated cases of tracheobronchial adenois cystic carcinoma, Proceedings of the Japanese Lung Cancer Society
Lung cancer., 48:261-265, 2008 (in Japanese) .

Case Reports
0620D001

K.Sato, M.Nakano, T.Terauchi, M.Takenaka, Y.Asakura, S.Kaji, T.Nojima, Y.Ueda: A case of large cell lungcarcinoma with rhabdoid phenotype, J. Jpn. Soc. Clin. Cytol., 47:64-68, 2008 (in Japanese) .

0620D003

K.Sato, T.Terauchi, Y.Asakura, M.Takenaka, M.Nakano, N.Kurose, Y.Ueda, M.Hirokawa: A case of thyroid
oxyphilic follicular carcinoma with distinct trabecular growth pattern, J. Jpn. Soc. Clin. Cytol., 47:200-204, 2008
(in Japanese) .

0620D004

M.Takenaka, K.Sato, T.Terauchi, M.Yamashita, Y.Asakura, M.Nakano, N.Kurose, T.Nojima: A case of diffuse large
B-cell lymphoma hardly differentiating from high-grade urothelial carcinoma in cytology, J. Jpn. Soc. Clin. Cytol.,
47:296-300, 2008 (in Japanese) .

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0630

Department of General Internal Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

YAMAKAWA Junichi

General medicine,Kampo medicine

KUSAKA Kazuya

Diaqnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer, earygastric cancer, eary colon cancer

MORIYA Junji

General medicine,Kampo medicine

Keywords of Researchcardiology, neurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity,
cytokine, infection

Outline of Research
Three major investigations are proceeded. One is to investigate thetherapeutic implication of cytokine against viral myocarditis, chronic
fatigue syndrome, infection due to obese through immunomodulation. The
second is to apply the kampo
medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, Q.Li, S.Morimoto, K.Iwai, H.Sumino, N.Yamaguchi, T.Kanda: Brain
atrophy in a murine model of chronic fatigue syndrome and beneficial effect of hochu-ekki-to(TJ-41), Neurochem.
Res., 33:1759-1767, 2008.

0630B002

J.Yamakawa, Y.Ishigaki, F.Takano, T.Takahashi, J.Yoshida, J.Moriya, T.Takata, T.Tatsuno, K.Sasaki, T.Ohta,
T.Takegami, F.Yoshizaki: The kampo medicines orengedokuto, bofutsushosan and boiogito have different activities
to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles,
Biol.Pharm.Bull., 31:2083-2089, 2008.

0630B003

F.Yu, R.Chen, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto, T.Kanda: Candesartan
improves myocardial damage in obese mice with viral myocarditis and induces cardiac adiponectin, Int. J. Cardiol.,
129:414-421, 2008.

0630B004

K.Iwai, T.Takahashi, T.Nakahashi, K.Nomura, M.Atsumi, L.Zeng, K.Ishigami, T.Kanda, N.Yamaguchi, S.Morimoto:
Immobilization stress inhibits intimal fibromuscular proliferation in the process of arterial remodeling in rats,
Hypertens. Res., 31:977-986, 2008.

Reviews
0630C001

R.Chen, F.Liang, J.Moriya, J.Yamakawa, T.Takahashi, L.Shen, T.Kanda: Peroxisome proliferator-activatedreceptors(ppars) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?, Int.
J. Cardiol., 130:131-139, 2008.

0630C002

Q.Li, R.Chen, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi: A novel adipocytokine, visceral adipose
tissue-derived serine protease inhibitor(vaspin),and obesity, J. Int. Med. Res., 36:625-629, 2008.

－ 98 －

0630C003

R.Chen, FX.Liang, J.Moriya, J.Yamakawa, H.Sumino, T.Kanda, T.Takahashi: Chronic fatigue syndrome and thecentral nervous system, J. Int. Med. Res., 36:867-874, 2008.

Case Reports
0630D001

J.Moriya, J.Yamakawa, R.Chen, H.Takagi, S.Makinoda, T.Takahashi, T.Kanda: A large ovarian tumor mimicking
the accumulation of ascites, J. Kanazawa. Med. Univ., 33:31-32, 2008.

0630D002

J.Moriya, J.Yamakawa, Y.Motoo: Effect of kampo medicine on the long-termadministration of NSAIDs in threecases of gonarthrosis, Pain and kampo medicine., 18：82-87, 2008 (in Japanese) .

Others
0630F001

K.Nomura, H.Murai, T.Nakahashi, S.Mashiba, Y.Watoh, T.Takahashi, S.Morimoto: Outbreak of norovirus
gastroenteritis in elderly evacuees after the 2007 Noto peninsula earthquake in Japan, J. Am. Geriatr. Soc.,
56:361-363, 2008.

0630F002

T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, K.Iwai, M.Atsumi, K.Ishigami, T.Inamatsu, S.Morimoto:
Association between seroprevalence of human metapneumovirus and c-reactive protein level and apolipoprotein eε4 allele in elderly inpatients in Japan, J. Am. Geriatr. Soc., 56:1758-1760, 2008.

Presentations at Conference
International Conference (Presentations)
0630I001

T.Kanda, K.Kusaka, T.Takahashi, J.Moriya, J.Yamakawa, R.Chen, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai:
Candesartan regulates polarization of Th1 and Th2 cytokines in lymphoid organs of obese mice with acute
myocarditis, Basic Cardiovascular Sciences Conference 2008, (Colorado, '08.07).

－ 99 －

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

SHIROEDA Hisakazu Endoscopic therapy of early gastic cancer

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer

Publications
Others
0640F001

M.Yamada, H.Kawahara, H.Shiroeda, M.Tsuchishima, Y.Masaki, K.Sato, S.Takase: Successful rituximab
monotherapy for API2-MALT1 fusion posotive primary mucosa-associated lymphoid tissue lymphoma of thetransverse colon in a patient with liver cirrhosis, Scand. J. Gastroenterol., 43:761-764, 2008.

－ 100 －

0650

Department of Rehabilitation Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

YAMAGUCHI Masao

Gait analysis using EMG power spectrum．Sway paths of the center ofgravity；post hip surgery of the patient with osteoarthritis of the hip．
Clinical pathway of the patient with femoral neck fractur.

SUGIMOTO Atsuo

Rehabilitation science/welfare engineering

NAKATA Minori

Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0650B002

M.Tsubokawa, K.Kyoda, T.Ito, K.Yabukoshi, H.Kawasaki, M.Yamaguchi: Ingestion and swallowing abilities of
elderly patients over the age of 75 years with pneumonia, J. Kanazawa. Med. Univ., 33:69-75, 2008 (in Japanese) .

0650B007(H.Kawasaki), C.Motomura, R.Yamada, S.Fujita, E.Iida, M.Tsubokawa, M.Yamaguchi: Effectiveness of alternate
swallowing of jelly food for removing residual food on the pharynx in dysphagia patients, The Japanese journal ofdysphagia rehabilitation., 12:223-232, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0650I001

A.Kobe, M.Minamizuka, K.Kuriiwa, J.Kiyoi, T.Muratani, M.Oda, M.Yamaguchi, A.Kaneuji, T.Matsumoto: Control
in Motor units on gluteus medius muscles of hip osteoarthritic persons withD-T sign during free walking., 10th
International Congress of the Asian Confederation for Physical Therapy, (Chiba, '08.08)，10th International
Congress of the Asian Confederation for Physical Therapy Program & Abstract, 90, 2008.

－ 101 －

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name
SAKUMA Tsutomu
SAGAWA Motoyasu
USUDA Katsuo(Additional Post)

Field of Specialization
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema.
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening.
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology,

AIKAWA Hirokazu

thoracic surgery, lung cancer, video assisted thoracoscopic surgery．

KANNO Masaaki

Thoracic surgery

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy－ 102 －

Publications
Originals
0660B001

G.Ma, X.Zhao, M.Ueno, M.Tanaka, Y.Machida, H.Aikawa, K.Usuda, M.Sagawa, Y.Ueda, T.Sakuma: Increased
reabsorption of alveolar edema fluid in the obese zucker rat, Tohoku J. Exp. Med., 216:223-230, 2008.

0660B002

M.Sagawa, K.Usuda, K.Tsuchihara, H.Aikawa, Y.Machida, M.Tanaka, M.Ueno, K.Nakagawa, T.Sakuma:
Conparison of the images of virtual bronchoscopy under the different conditions, Ｔhe Japanese journal of thoracic
surgery., 61:102-108, 2008 (in Japanese) .

0660B003

H.Aikawa, M.Sagawa, M.Tanaka, Y.Machida, M.Ueno, K.Usuda, T.Tobe, H.Toga, T.Sakuma: Endobronchial
treatment using spiral-z stent and electrosurgery, J. Kanazawa. Med. Univ., 33:141-144, 2008 (in Japanese) .

Reviews
0660C001

H.Aikawa, M.Sagawa, K.Usuda, M.Ueno, M.Tanaka, Y.Machida, T.Sakuma: Multidisciplinary treatment of lungcancer in 21st century, Ｔhe Japanese journal of thoracic surgery., 61:51-54, 2008 (in Japanese) .

0660C003

Y.Ueda, M.Shimasaki, K.Higashi, G.Guo, K.Sato, M.Sagawa, T.Sakuma, S.Katsuda: Recent advance in thepathology of lung cancer, J. Kanazawa. Med. Univ., 33:21-30, 2008 (in Japanese) .

Case Reports
0660D001

K.Usuda, M.Sagawa, H.Aikawa, M.Tanaka, Y.Machida, M.Ueno, T.Sakuma: Virtual bronchoscopic navigation isuseful in the diagnosis of synchronous pulmonary squamous cell carcinomas, J. Bronchol., 15:104-106, 2008.

0660D002

X.Zhao, M.Tanaka, M.Ueno, Y.Machida, H.Aikawa, K.Usuda, M.Sagawa, Y.Ueda, T.Sakuma: Mediastinal
parathyroid cyst dissected under video-assisted thoracoscopic surgery: Report of a case, J. Kanazawa. Med. Univ.,
33:153-155, 2008.

0660D003

M.Sagawa, H.Aikawa, K.Usuda, Y.Machida, M.Tanaka, M.Ueno, Y.Ueda, T.Sakuma: Extended sleeve pulmonary
resection in patient with synchronous triple bronchogenic squamous cell carcinoma, Lung Cancer, 59:262-265,
2008.

0660D004

Y.Machida, M.Tanaka, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: Sclerosing hemangioma of lung with FDG and201
T1 uptake: Report of a case, 日呼外会誌, 22:71-74, 2008 (in Japanese) .

－ 103 －

0670

Lifestyle-related Diseases Center

Title

Name

Field of Specialization(Additional Post)

MATSUI Shinobu

cardiac function, echocardiography, myocardial metabolism(Additional Post)

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterosecretiol

Faculty

Physical physiology(The exercise testing and prescription from thephysiological and biochemical research), Effects of the anemia on thephysical activitiy, Exercise therapy for the lifestyle-related disease,
Training for health Medical Education.
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning(Additional Post)

TAMURA Nobuki(Additional Post)

HORI Ariyuki(Additional Post)

NAKANISHI Yumiko

Preventive medicine.

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology.

KITADA Munehiro

diabetes, hypertension.

KAMODA Sachikolifestyle-related disease, Preventive medicine.

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

Publications
Originals
0670B001

K.Takeda, S.Akazawa, Y.Kawai, K.Kajinami: Regulation of pssitive feedback loop of HB-EGF signal by gene
33/ralt in H9c2 cells, J. Kanazawa. Med. Univ., 33:76-85, 2008.

0670B002

S.Abe, S.Ohta, K.Uchida: The effect of diastolic dysfunction and hypertension in diabetes mellitus－Examination ofleft ventricular diastolic dysfunction using the valsalva maneuver－, Journal of the Japan Diabetes Society.,
51:213-218, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0670I001(H.Akazawa), N.Ysuda, S.Miura, T.Tanaka, Y.Qin, S.Kudoh akazawa, I.Komuro: Conformational switch ofangiotensin Ⅱtype 1 recepter underlying mechanical stress-induced activation, KEYSTONE G Protein-Coupled
Receptors, (London, '08.05).

－ 104 －

0680

Medical Genetic Center

Faculty
Title

Name

Field of Specialization(Additional Post)

KAKINUMA Hiroaki

child neurology, inborn errors of metabolism, congenital malformation,
medical genetics(Additional Post)

ITO Masatsune

child endocrinology(Additional Post)

SATO Hitoshi

clinical virology, child infectious disease

Keywords of Research
genetic variation, genetic mutation, genetic counseling, copy number variation

Outline of Research
genetic counseling, clinical genetics, congenital anomaly, child neurology, inborn
errors of metabolism, pediatric endocrinology.

Publications
Short Communications
0680E001

H.Kakinuma, M.Ozaki, H.Sato, H.Takahashi: Variation in GABA-A subunit gene copy number in an autistic
patient with mosaic 4 p duplication (p12p16), Am. J. Med. Genet. B Neuropsychiatr. Genet., 147B:973-975, 2008.

Presentations at Conference
International Conference (Presentations)
0680I001

M.Ito, H.Kakinuma: Functional studies of a duplication mutation of valine at 235 by a transient expression assay ina boy with mct8 deficiency, SSIEM 2008, (Lisboa, '08.09)，JIMD, 31 Suppl 1:139, 2008.

－ 105 －

0690

Department of Endoscopy

Faculty
Title

Name
ITOU Tohru

URASHIMA Sachio

KAWAURA Ken

Field of Specialization
Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopicaltreatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)－ 106 －

0700

Multidisciplinary Cancer Center

Name

Field of Specialization

MOTOO Yoshiharu

Medical Oncology

NAKAJIMA Hideo

Medical Oncology

SHIMASAKI Takeo

Medical Oncology

NAKAYA Naoki

Medical Oncology

TSUJI Hiroyuki

Head & Neck Surgery

Faculty
Title(Additional Post)

Outline of Research
Our main task is outpatient chemotherapy, which is requested by other Departments of the hospital. We are also involvedin clinical trials on chemotherapy, and in translational research using clinical samples such as blood and urine of patients.

Presentations at Conference
International Conference (Synposium)
0700H001

Y.Motoo: Intergration of heｒbal medicine into multidisciplinary treatment and holistic care of cancer patients, 2008
Internaional Symposium of East-West Medicine for Cancer Treatment, (Seoul, '08.10).

0700H002

Y.Motoo: Current status of Kampo（Japanese herbal)medicine, 1st Asia Pacific Traditional and Complemantary
Medicine Conference 2008, (Kuala Lumpur，Malaysia, '08.11).

International Conference (Presentations)
0700I001

Y.Motoo: Ｇene expressoin analysis in gemcitabine-treated human pancreatic cancer cells;GSK-3beta as a new
therapeutic target, BIT's Annual WORLD Canser CONGRESS-2008, (Shanghai, China, '08.02).

0700I002(Mai W), A.Shakoori, K.Miyashita, Zhang B, Y.Motoo, K.Kawakami, Y.Takahashi, T.Minamoto: Detection of active
fraction of GSK3beta in cancer cells by non-raioisotopic in vitro kinase assay, AACR Aｎnual Meeting 2008, (San
Diego, CA, USA, '08.04).

－ 107 －

－ 108 －Ｓｃｈｏｏｌ ｏｆ Ｎｕｒｓｉｎｇ

8010

Basic Nursing

Faculty
Title

Name

Field of Specialization

TAWARA Tomoe

Feelings and QOL of sinior sitizuns living care-house run by amanicipal government or private sector.

SAKAI Keiko

Proficiency and stressor of teachers in nursing.

KIMOTO Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireKeywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

－ 109 －

8030

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

KITAOKA Kazuyo

Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability

NAGAI Makie

Occupational Mental Health

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has developed the Japanese research version of the Maslach
Burnout Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support
those people with mental disabiltiy.

Publications
Originals
8030B001(A.Shimazu), WB.Schaufeli, S.Kosugi, A.Suzuki, H.Nashiwa, A.Kato, M.Sakamoto, H.Irimajiri, S.Amano,
K.Hirohata, R.Goto, K.Kitaoka-Higashiguchi: Work engagement in Japan: validation of the Japanese version of the
Utrecht Work Engagment Scale, Applied psychology : an international review., 57: 510-523, 2008.

8030B002

M.Nagai: Nursing practice towards mental health promotion: evaluation of independent action in fresh employee
and analysis of nursing practice, Journal of Japan Academy of Psychiatric and Mental Health Nursing., 17: 1-11,
2008 (in Japanese) .

8030B004

Y.Hamazaki, K.Fukuma, M.Nagai: Living ezperiences with ossification of posterior longitudinal ligament and it's
characteristics－focus on physical, mental and social condition－, J. J. Intrac. Ill. Nurs., 13:149-157, 2008 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
8030I001

K.Kitaoka, Y.Morikawa, S.Matsuda, K.Ogino, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Burnout and riskfactors for arteriosclerotic disease: follow-up study, 3rd ICOH International Conference on
Psychosocial Factors at work, (Quebec, '08.09)，2008.

8030I002(K.Ohnishi), M.Nakano, Y.Ohgushi, H.Tanaka, K.Kitaoka: Development of moral distress scale in psychiatric carein Japan, The RCN 14th International NPNR (Network for Psychiatric Nursing Research) Conference, (Oxford, UK,'08.10).

－ 110 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing.

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring.

UCHIDA Maki

Cancer Nursing, Terminal Care.

KITAMURA Yoshiko

Cancer Nursing.

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease.

Keywords of Research
Nephrology Nursing, Transplant Nursing, Cronic Disease Nursing, Terminal Care, Cancer Nursing, Nursing Ethics

Outline of Research
Clinical Medical-Surgical Nursing.

－ 111 －

8050

Nursing of the Elderly

Faculty
Title

Name

Field of Specialization

HASHIMOTO Tomoe community/elderly nursing science

Keywords of Research
Nursing of the Elderly

Outline of Research
Verification of Nursing Care about Daily living activities and their communication of the elderly with Dementia,also,theeffectiveness of the elderly Dementia prevention on the basis Local residents.
The Study of General Principle of Florence Nightingale connected with Nurse's recognition and expression in Nursing
phenomenon.

－ 112 －

8060

Child Nursing

Faculty
Title

Name

Field of Specialization

TSUDA Akiko

Pediatric Nursing

OGURA Mutsumi

child nursing

Keywords of Researchchild, parenting, parenting support, attachment, daily living life, biological rhythm

Outline of Research
The study on biological rhythm and life style in childhood.

－ 113 －

8070

Maternity Nursing

Faculty
Title

Name

Field of Specialization

OCHIAI Fumie

Maternity Health, Child Health, Midwifery.

SASANO Kyoko

Crinical nursing, Nursing education.

YORITSUNE Kaoru

Life development nursing.

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8070B001

K.Sasano, A.Sakai: Experience of primiparous women who continued breastfeeding for three months, J. Tsuruma
Health Sci. Soc., 32:1-12, 2008.

Reviews
8070C001(C.Miyamoto), K.Yoritsune, T.Hasegawa: A systematic review: The effect of prevention interventions for foodallergies during childhood, The journal of the Nursing Society of University of Toyama., 8:1-9, 2008 (in Japanese) .

－ 114 －

8080

Community Nursing

Faculty
Title

Name

Field of Specialization

FUKUMA Kazumi

Community Health Nursing

HAMAZAKI Yuko

public health nursing study of elder abuse

MATSUMOTO
YoshikoCommunity Health nursing

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, successful aging, activity of cmmunity
organization

Outline of Research
We aim at the research of community nursing that contributes to sustain and improve quality of life and health of people inthe community. We have been studying about community nursing-care activity, community nursing education, Healthpromotion, successful aging and elder abuse

Publications
Originals
8080B001

Y.Hamazaki, K.Saeki, Y.Morikawa, K.TsukazakiI, T.Kido: Relations between physical/mental function and social
activities of independent elderly people-analysis of social activities of elderly who participate in the association of
graduates of a learning course for elderly people-, Hokuriku Japanese Journal of Public Health., 35：6-11, 2008 (inJapanese) .

8080B002

Y.Hamazaki, K.Fukuma, M.Nagai: Living ezperiences with ossification of posterior longitudinal ligament and it's
characteristics－focus on physical, mental and social condition－, J. J. Intrac. Ill. Nurs., 13:149-157, 2008 (inJapanese) .

－ 115 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

MAEDA Shukohome care , home health care nurse.

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
Practice and restructuring of the infection control edcation program for home visiting nurses－ 116 －

8100

Human Science

Faculty
Title

Name

Field of Specialization

ISHIBASHI Takaharu

Cardiovascular Pharmacology

OKADA Masato

Peripheral nerve surgery, Trauma

KAKINUMA Hiroaki

Pediatric neurology, Pediatric clinical genetics

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

HONDA Ryumon

Environment and health, Epidemiology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial changes in urinary
cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies,
Toxicol. Lett., 176:124-130, 2008.

8100B002

Takaharu Ishibashi, Tomoko Miwa, Shinkawa, Naoki Nishizawa, Nomura, Junko Yoshida, Tome Kawada, Matomo
Nishio: Quantifying nanomolar levels of nitrite in biological samples by HPLC-Griess method: Special reference toarterio-venous difference in vivo, Tohoku J. Exp. Med., 215 (1): 1-11, 2008.

8100B003(A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki: Computation of temperature elevation in rabbit
eye irradiated by 2.45-GHz microwaves with different field configurations, Health Phys., 92:134-144, 2008.

8100B004

K.Miura, A.Matumori, A.Nasermoaddeli, Y.Soyama, Y.Morikawa, M.Sakurai, A.Kitabatake, M.Nagai, Y.Inaba,
H.Nakagawa: Prognosis and prongostic factors in patients with idiopathic dilated cardiomyopathy in Japan―resultsfrom a nationwide study―, Circ. J., 72:343-348, 2008.

8100B005(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, M.Nishiho, T.Kido, H.Nakagawa: Estimation of benchmark doses
as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and nonpolluted regions in Japan, Toxicology Lett., 179:108-112, 2008.

－ 117 －

8100B006

Y.Morikawa, K.Miura, S.Sasaki, K.Yoshita, S.Yoneyama, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
M.Higashiyama, H.Nakagawa: Evaluation of the effects of shift work on nutrient intake:a cross-sectional study, J.
Occup. Health, 50:270-278, 2008.

8100B007(A.Hirata), H.Sugiyama, M.Kojima, H.Kawai, Y.Yamashiro, O.Fujiwara, S.Watanabe, K.Sasaki: Computationalmodel for calculating body-core temperature elevation in rabbits due to whole-body exposure at 2.45 GHz, Phys.
Med. Biol., 53:3391-3404, 2008.

8100B008

T.Ishibashi, T.Miwa, I.Shinkawa, N.Nishizawa, M.Nomura, J.Yoshida, M.Nishio: Quantifying nanomolar levels of
nitrite in biological samples by HPLC-Griess method: Special reference to arterio-venous difference in vivo,
Tohoku J. Exp. Med., 215:1-11, 2008.

8100B009

K.Sunaga, K.Miura, Y.Naruse, M.Sakurai, Y.Morikawa, Y.Kurosawa, H.Nakagawa: Glycated hemoglobin and risk ofstroke, ischemic and hemorrhagic, in Japanese men and women, Cerebrovasc. Dis., 26:310-316, 2008.

8100B010(T.Ninomiya), Y.Kiyohara, Y.Tokuda, Y.Doi, H.Arima, A.Harada, Y.Ohashi, H.Ueshima, Japan Arteriosclerosis
Longitudinal Study Group, H.Nakagawa, K.Miura, Y.Morikawa, M.Ishizaki: Impact of kindey disease and bloodpressure on the development of cardiovascular disease: an overview from the Japan Arteriosclerosis Longitudinal
Study., Circulation, 118:2694-2701, 2008.

8100B011

M.Ishizaki, H.Nakagawa, Y.Morikawa, R.Honda, Y.Yamada, N.Kawakami, The Japan Work Stress and HealthCohort Study Group: Influence of job strain on changes in body mass index and waist circumference-6-year
longitudinal study, Scand. J. Work Environ. Health, 34:288-296, 2008.

8100B012

Y.Yasui, S.Miyamoto, M.Kim, H.Kohno, S.Sugie, T.Tanaka: Aqueous and ethanolic extract fractions from theBarazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Oncol. Rep., 20:493-499, 2008.

8100B013(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Changes in renal tubular andglomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculatedwith a general linear mixed model, Biol Trace Elem Res, 124:164-172, 2008.

8100B014(T.Watanabe), M.Miyao, R.Honda, Y.Yamada: Hiroshima survivors exposed to very low doses of A-bomb primaryradiation showed a high risk for cancers, Environ. Health Prevent. Med., 13:264-270, 2008.

8100B015

M.Nishijo, K.Tawara, H.Nakagawa, R.Honda, T.Kido, H.Nishijo, S.Saito: 2,3,7,8-Tetrachlorodibenzo-p-dioxin inmaternal breast milk and newborn head circumference, J. Expo. Sci. Environ. Epidemiol., 18：246-251, 2008.

8100B020

M.Nakashima, K.Miura, Y.Morikawa, M.Nishijo, Y.Nakanishi, M.Sakurai, H.Nakagawa: Effect of smoke-free medical
school on smoking behavior of medical students, Japanese Journal of Public Health., 55:647-654, 2008 (inJapanese) .

Reviews
8100C001

H.Kakinuma, H.Sato: Copy-number variations associated with autism spectrum disorder, Pharmacogenomics,
9:1143-1154, 2008.

Short Communications
8100E001

H.Kakinuma, M.Ozaki, H.Sato, H.Takahashi: Variation in GABA-A subunit gene copy number in an autistic
patient with mosaic 4 p duplication (p12p16), Am. J. Med. Genet. B Neuropsychiatr. Genet., 147B:973-975, 2008.

Others
8100F001

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, A.Hirata, Y.Sakamoto, Y.Kawakami, S.Watanabe, K.Wake, M.Taki,
Y.Kamimura, H.Sasaki, K.Sasaki: Investigation of wavelength-specific characteristics of quasi- and millimeterwaves, URSI, KP214:1-4, 2008.

8100F007(C.Aoki), M.Higashiyama, Y.Nakashima, H.Takayosi, C.Okamoto, E.Nagayama, C.Kobayashi, T.Kido, K.Miura,
Y.Morikawa, M.Sakurai, K.Nakamura, H.Nakagawa, M.Ishizaki, Y.Naruse: Smoking cessation rate and its related
factors on a smoking cessation support program in a workplace, Hokuriku Japanese Journal of Public Health.,
35:36-38, 2008 (in Japanese) .

－ 118 －

8100F008(C.Okamoto), M.Higashiyama, E.Nagayama, C.Aoki, H.Takayoshi, Y.Nakashima, C.Kobayashi, K.Miura,
M.Sakurai, K.Nakamura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Effects of educational program
under a tutorial or a small-group system on body weight loss for obese participants in a workplace, Hokuriku
Japanese Journal of Public Health., 35:39-41, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8100I001

M.Sakurai, K.Miura, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of long-term body weight change to HDL particle size change in Japanese men and women:The
INTERMAP Toyama study. Joint conference, 49th Cardiovascular Disease Epidemiology and Prevention -andNutrition, (Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

8100I002

K.Miura, M.Sakurai, R.Naganuma, Y.Morikawa, S.Yoneyama, H.Nakagawa, K.Yoshita, H.Ueshima, J.Stamler:
Relation of 9-year body weight change to change in LDL particle size in Japanese men and women:The INTERMAP
Toyama study, Joint Conference -49th Cardiovascular Disease Epidemiology and `revention -and- Nurtrition,(Colorado, '08.03)，Physical Activity and Metabolism, 103, 2008.

8100I003

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, Y.Sakamoto, Y.Kawakami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of millimeter wave exposure through ocular temperature measurement andheat transportation, Association for Research in vision and Ophthalmology, (Florida, '08.04).

8100I004

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Protective effect of topical
5-S-GAD on UV-B- induced cataract in rats, Association for Research in Vision and Ophthalmology, (Florida,'08.04).

8100I005

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.lu, J.Zhang, K.Sasaki: Prevalence of pseudoexfoliation inchina, Association for Research in Vision and Ophthalmology, (Florida, '08.04).

8100I006

Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, Y.Kawakami, J.Qu, K.Sasaki, H.Sasaki: Does corneal curvatureradius contribute to pathogenesis of pterygium? -A report from chinese ophtalmic surveys in Hainan and Shanxi,
Association for Research in Vision and Ophthalmology, (Florida, '08.04).

8100I007Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, T.Saeki, A.Azumi, S.Nakada,S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano, Y.Zen, M.Kaneko, K.Miyazaki,
K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, S.Sugai, H.Umehara: Proposal for A new clinicalentity, IGG4-Positive Multi-Organ Lymphoproliferative syndrome : analysis of 64 cases of IGG4-Relateddisorders., 10th International Conference on Malignant Lymphoma, (Switzerland, '08.06).

8100I008

M.Kojima, T.Sakai, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, Y.Kawanami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of Quasi and millimeter wave exposure through ocular temperature
measurement and heat transportation, The Bioelectromagnetics in Society 30th Annual Meeting, (San Diego,'08.06).

8100I009

H.Osada, Y.Yamashiro, R.Honda, Y.Sakamoto, K.Nagai, Y.Kawakami, K.Sasaki, H.Sasaki: Posterior capsule
opacifiation in rural areas of China, The 7ｔｈ Asian Cataract Research Conference in Conjunction with Cataract
Satellite Meeting of the 18th International conference for Eye Research and the 11th Conference of Chinese
Cataract Society, (Xi'an, '08.09).

8100I010

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: Effect factors oflens thickness, The 7th Asian Cataract Research Conference in Conjunction with Cataract Satellite Meeting of the
18th international Conference for Eye Research and the 11th Conference of Chinese Cataract Society Clinical
Warkshop, (Xi'an, '08.09).

8100I011

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract, The 7th Asina Cataract Research Conference in Conjunction with Cataract satellite Meeting of the 18th
International Conference for Eye Research and the 11th Conference of Chinese Cataract Society, (Xi'an, '08.09).

－ 119 －

8100I012

Y.Morikawa, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, H.Nakagawa, Y.Naruse, M.Higashiyama: Drinking habit
among shift workers and its health effects, 3rd ICOH International Conference on Psychosocial Factors at work,(Quebec, '08.09)，2008.

8100I013

K.Kitaoka, Y.Morikawa, S.Matsuda, K.Ogino, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Burnout and riskfactors for arteriosclerotic disease: follow-up study, 3rd ICOH International Conference on
Psychosocial Factors at work, (Quebec, '08.09)，2008.

－ 120 －

ＭｅｄｉｃａｌＲｅｓｅａｒｃｈＩｎｓｔｉｔｕｔｅ／
ＣｅｎｔｅｒｆｏｒＦＤＤ‐ＭＢ0710

Medical Research Institute

Faculty
Title

Name

Field of Specialization

DATE Takayasu

Mechanisms of chromosome segregation and DNA repair.

Keywords of Research
Gene analysis, PKU-β(TLK1), PKU-α(TLK2), DNA repair, cell cycle, signal transduction, chromosome

Outline of Research
Our research is to clarify the function of nuclear protein kinases.
PKU-alpha/TLK2 and PKU-beta/TLK1. Much of the work in our laboratory has focused on identifiying the role of PKUbeta/TLK1 in cell proliferation.

Publications
Originals
0710B001

K.Iwabuchi, M.Hashimoto, T.Matsui, A.Kurosawa, N.Adachi, T.Date: Cell sorting analysis of cell cycle-dependent
X-ray sensitivity in end joining-deficient human cells, Biochem. Biophys. Res. Commun., 372:662-667, 2008.

0710B002

K.Iwabuchi, T.Matsui, M.Hashimoto, Y.Matsumoto, T.Kurihara, T.Date: Characterization of a cancer cell line that
expresses a splicing variant form of 53BP1:Separation of checkpoint and repair functions in 53BP1, Biochem.
Biophys. Res. Commun., 376:509-513, 2008.

0710B003

M.Hashimoto, T.Matsui, K.Iwabuchi, T.Date: PKU-β/TLK1 regulates myosin Ⅱ activities, and is required for
accurate equaled chromosome segregation, Mutat. Res., 657:63-67, 2008.

Presentations at Conference
International Conference (Presentations)
0710I001

K.Iwabuchi, M.Hashimoto, T.Matsui, T.Date: Indentification of a cancer cell-line that expresses a splicing variant
form of 53BP1:separation of checkpoint and repair functions in 53BP1, The International Ataxia-Telangiectasia
Workshop2008, (Otsu, '08.04)，Ataxia-Telangiectasia Workshop2008 Abstracts, 141, 2008.

0710I002

T.Date, M.Hashimoto, T.Matsui, M.Ozaki, K.Iwabuchi: PKU-beta/TLK1 plays a dual role in both centrosome
separation and chromosome segregation, 33th FEBS Congress 11th IUBMB Conference, (Athens, '08.06)，
Abstracts, 112, 2008.

－ 121 －

0740

Division of Human Genetics (Biochemistry)

Faculty
Title

Name
KUHARA Tomiko
SHINKA Toshihiro

INOUE Yoshito
OHSE Morimasa

Field of Specialization
Human metabolome analysis for diagnosis of metabolic disorders andpersonalized medicine
Chemical diagnosis of metabolic disorders by mass spectrometry(Tyrosinosis, Metabolic disorders of fatty acid beta oxidation,
Acylcarnitine analysis, Sulfated bile acids analysis)
Chemical diagnosis and follow up study for metabolic disorders (ureacycle disorders, prenatal diagnosis of organic acidemias, Canavan
disease, optical isomer analysis)
Development of data handling method from mass measurement value
to evaluation value in diagnosis software

Keywords of Researchhuman genetics, metabolome, pharmacogenomics, nutrinogenomics, metabolomics, mass spectrometry, inborn errors of
metabolism, molecular diagnosis, organic acidemia, gas chromatography-mass spectrometry, chemical diagnosis, pilot studyof neonatal screening, prenatal diagnosis, personalized medicine, stable isotope dilution, tandem mass spectrometry,electrosplay ionization mass spectrometry, 5-fluorouracil toxicity, metabolic profiling, aminoacidemia/aminoaciduria, fatty
acid β-oxidation, carnitine, acylcarnitine

Publications
Originals
0740B001

Y.Inoue, M.Ohse, T.Shinka, T.Kuhara: Prenatal diagnosis of propionic acidemia by measuring methylcitric acid in
dried amniotic fluid on filter paper using GC/MS, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 870:160163, 2008.

0740B002

T.Shinka, M.Ohse, Y.Inoue, K.Kataoka, Y.Kondou, T.Kuhara: Comparison of urinary organic acids in mediumchain Acyl-CoA dehydrogenase deficiency and MCT milk-treated patients by GC/MS, J. Kanazawa. Med. Univ.,
33:112-116, 2008 (in Japanese) .

Case Reports
0740D001(P.Wasant), S.Liammongkolkul, C.Kuptanon, N.Vatanavicharn, A.Sathienkijakanchai, T.Shinka: Organic aciddisorders detected by urine organic acid analysis: twelve cases in Thailand over three-year experience, Clin. Chim.
Acta, 392:63-68, 2008.

Presentations at Conference
International Conference (Presentations)
0740I001(T.Takayama), N.Takaoka, M.Miyazaki, M.Nagata, S.Mugiya, K.Johnin, Y.Okada, T.Kuhara, S.Cramer, S.Ozono:
The relationship between molecular analysis and ethnic differences of genotype in Japanese patients with primary
hyperoxaluria type 2, 11th International Symposium on Urolithiasis, (Nice, France, '08.09).

－ 122 －

0750

Division of Human Genetics (Clinical Medicine)

Faculty
Title

Name

Field of Specialization(Additional Post)

KAKINUMA HiroakiChild neurology, inborn errors of metabolism, clinical genetics

TAKABAYASHI Haruo fetal medicine, DNA medicine
OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Keywords of Research
genetic counseling, genetic service, prenatal diagnosis, congenital abnormality

Publications
Originals
0750B001

M.Ozaki, Y.Ishigaki: Copmparative study of chromosomal analysis using SNPs genotyping arrays and G-banding in
MCA/MR(multiple congenital abnormality / mental retardation) patients, J. Kanazawa. Med. Univ., 33:1-12, 2008
(in Japanese) .

Case Reports
0750D001

K.Sato, Y.Ueda, S.Miwa, A.Yokogawa, M.Ozaki, S.Katsuda: Low-grade malignant soft-tissue perineurioma:
interphase fluorescence in situ hybridization, Pathol. Int., 58:718-722, 2008.

Short Communications
0750E001

H.Kakinuma, M.Ozaki, H.Sato, H.Takahashi: Variation in GABA-A subunit gene copy number in an autistic
patient with mosaic 4 p duplication (p12p16), Am. J. Med. Genet. B Neuropsychiatr. Genet., 147B:973-975, 2008.

－ 123 －

0770

Division of Core Facility (Radioisotope Center)

Faculty
Title

Name

Field of Specialization

ISHIGAKI Yasuhito

Molecular and Cellular Biology

YAMASHITA
Masatoshi

Radiation Safety Management

Keywords of Research
RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis,
Energy-filtering electron microscopy, Element mapping, Ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, centrosome, tumor growth angiogenesis, micro RNA

Outline of Research
Quality control of genetic information

Publications
Originals
0770B001

E.Simamura, H.Shimada, Y.Ishigaki, T.Hatta, N.Higashi, K-I.Hirai: Bioreductive activation of quinone antitumor
drugs by mitochondrial voltage-dependent anion channel 1, Anat. Sci. Int., 83:261-266, 2008.

0770B002(T.Takata), T.Taanaka, N.Yahagi, R.Yahagi, H.Tsuchida, Y.Ishigaki, N.Tomosugi, S.Fushiya, F.Takano, T. Ohta:
The liquid culture filtrates of entomogenous fungus Paecilomyces tenuipes and its glycoprotein constituent protects
against anemia in mice treated with 5-fluorouracil, Biol.Pharm.Bull., 31:1565-1573, 2008.

0770B003

J.Yamakawa, Y.Ishigaki, F.Takano, T.Takahashi, J.Yoshida, J.Moriya, T.Takata, T.Tatsuno, K.Sasaki, T.Ohta,
T.Takegami, F.Yoshizaki: The kampo medicines orengedokuto, bofutsushosan and boiogito have different activities
to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles,
Biol.Pharm.Bull., 31:2083-2089, 2008.

0770B004(T.Kiba), Y.Kintaka, Y.Suzuki, E.Nakata, T.Osaka, Y.Ishigaki, S.Inoue: Changes of neuron-specific and apoptosis
gene expression levels after ventromedial hypothalamic lesions in rat intestine, Exp. Biol. Med. (Maywood),
233:1368-1373, 2008.

0770B005(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

0770B006

M.Ozaki, Y.Ishigaki: Copmparative study of chromosomal analysis using SNPs genotyping arrays and G-banding in
MCA/MR(multiple congenital abnormality / mental retardation) patients, J. Kanazawa. Med. Univ., 33:1-12, 2008
(in Japanese) .

－ 124 －

Presentations at Conference
International Conference (Presentations)
0770I001

T.Takata, F.Takano, Y.Nakamura, Y.Ishigaki, T.Ohta: Aqueous extract of peanut coat and its main constituentprocyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin, The 4th KSP-JSP-CCTNM
Joint Symposium on Pharmacognosy, (Gangneung, Republic of Korea, '08.06)，The 4th KSP-JSP-CCTNM Joint
Symposium on Pharmacognosy, 209, 2008.

0770I002(K.Mitani), T.Takata, T.Tatsuno, J.Date, N.Ohta, R.Yahagi, Y.Ishigaki, F.Takano, T.Ohta: The liquid culture
filtrates of entomogenous fungs Paecilomyces tenuipes and its glycoprotein constituent protects against anemia in
mce-treted with 5-fluorouracil, The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, (Gangneung,
Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, 207, 2008.

0770I003(T.Tatsuno), T.Takata, Y.Ishigaki, F.Takano, T.Ohta: Proanthocyanidin-enriched fraction isolated from Diospyros
kaki peel inhibited malanogenesis in cultured human melanoma HMV-2 cells, The 4th KSP-JSP-CCTCCM Joint
Symposium on Pharmacognosy, (Gangneung, Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint
Symposium on Pharmacognosy, 210, 2008.

0770I004(J.Date), T.Takata, T.Tatsuno, Y.Ishigaki, F.Takano, T.Ohta: N-Glycoryl neuraminic acid from edible/toxic
mushroom Pleurocybella porrigens, The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, (Gangneung,
Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, 131, 2008.

0770I005(T.Tatsuno), T.Takata, Y.Ishigaki, F.Takano, T.Ohta: Proanthocyanidin-enriched fraction isolated from Diospyros
kaki peel inhibited melanogenesis in culutured human HMV-2 cells, The 4th KSP-JSP-CCTCCM Joint Symposiumon Pharmacognosy, (Gangneung, Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on
Pharmacognosy, 210, 2008.

0770I006(K.Mitani), T.Takata, T.Tatsuno, J.Date, N.Ohta, N.Yahagi, R.Yahagi, Y.Ishigaki, F.Takano, T.Ohta: The liquind
culuture filtrates of entomogenous fungs Paecilomyces tenuipes and its glycoprotein constituent protects against
anemia in mice-treated with 5-fluorouracil, The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy,(Gangneung, Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, 207,2008.

0770I007(J.Date), T.Takata, T.Tatsuno, Y.Ishigaki, F.Takano, T.Ohta: N-glycory neuraminic acid from edible/toxic
mushroom Pleurocybella porrigens, The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, (Gangneung,
Republic of Korea, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, 131, 2008.

0770I008

T.Takegami, M.Murakami, M.Sato, T.Ota, Y.Ishigaki: Analysis of gene expression in Japanese encephalitis virus
infected cells using microarray., 15th International Congress of Virology, ( Istanbul, '08.08).

－ 125 －

0780

Division of Core Facility (Experimental Animal Center)

Faculty
Title

Name

(Additional Post)

MATSUI Shinobu

Field of Specialization

Publications
Originals
0780B001

Z-P.Zong, S.Matsui, J-F.Han, S.Katsuda, ML.Fu: Involvement of thymus in amiodarone-treated autoimmune
myocarditis in rats, Int. J. Cardiol., 125:122-129, 2008.

0780B002(J-l.Wu), S.Matsui, Z-P.Zong, K.Nishikawa, B-G.Sun, S.Katsuda, M.Fu: Amelioration of myocarditis by statin
through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats, J. Mol. Cell. Cardiol.,
44:1023-1031, 2008.

0780B003(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

－ 126 －

0790

Division of Core Facility (Morphological Equipment Center)

Keywords of ResearchMechanism of Chromosomal Instability

Outline of ResearchMechanism of Chromosomal Instability

Publications
Originals
0790B001

K.Iwabuchi, T.Matsui, M.Hashimoto, Y.Matsumoto, T.Kurihara, T.Date: Characterization of a cancer cell line that
expresses a splicing variant form of 53BP1:Separation of checkpoint and repair functions in 53BP1, Biochem.
Biophys. Res. Commun., 376:509-513, 2008.

－ 127 －

0800

Division of Core Facility (High-Tech Research Center)

Faculty
Title

Name

Field of Specialization(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

KIM Mihye

Cancer chemoprevention by natural products.

SATO Kyoko

Biological system pharmaceutical science

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Publications
Originals
0800B001(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial changes in urinary
cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium-polluted rice paddies,
Toxicol. Lett., 176:124-130, 2008.

0800B002(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, M.Nishiho, T.Kido, H.Nakagawa: Estimation of benchmark doses
as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and nonpolluted regions in Japan, Toxicology Lett., 179:108-112, 2008.

0800B003(S.Miyamoto), Y.Yasui, M.Kim, S.Sugie, A.Murakami, R.Ishigamori-Suzuki, T.Tanaka: A novel rasH2 mouse
carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is usefulfor preclinical chemoprevention studies, Carcinogenesis, 29:418-426, 2008.

0800B004

Y.Yasui, S.Miyamoto, M.Kim, H.Kohno, S.Sugie, T.Tanaka: Aqueous and ethanolic extract fractions from theBarazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats, Oncol. Rep., 20:493-499, 2008.

0800B005

M.Kim, S.Miyamoto, S.Sugie, Y.Yasui, R.Ishigamori-Suzuki, A.Murakami, H.Nakagama, T.Tanaka: A tobaccospecific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice, In Vivo., 22:557564, 2008.

0800B006(S.Miyamoto), F.Epifano, M.Curini, S.Genovese, M.Kim, R.Ishigamori-Suzuki, Y.Yasui, S.Sugie, T.Tanaka: A novel
prodrug of 4’-geranyloxy-ferulic acid suppresses colitis-related colon carcinogenesis in mice, Nutr. Cancer.,
60:675-684, 2008.

0800B007(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Changes in renal tubular andglomerular functions and biological Acid-base balance after soil replacement in Cd-polluted rice paddies calculatedwith a general linear mixed model, Biol Trace Elem Res, 124:164-172, 2008.

0800B008

M.Nishijo, K.Tawara, H.Nakagawa, R.Honda, T.Kido, H.Nishijo, S.Saito: 2,3,7,8-Tetrachlorodibenzo-p-dioxin inmaternal breast milk and newborn head circumference, J. Expo. Sci. Environ. Epidemiol., 18：246-251, 2008.

0800B009(M.Nozue), N.Sarukura, M.Nishijo, H.Fujii, Y.Arai, A.Ishiwaki, N.Yoshiike, H.Nakagawa, K.Yoshita: A study on
seasonal variations in nutrients and food groups and the relation between vegetable consumption andnutrients/food groups in a rural ares of Toyama, Hokuriku Japanese Journal of Public Health., 34:58-64, 2008 (inJapanese) .

0800B010

M.Nakashima, K.Miura, Y.Morikawa, M.Nishijo, Y.Nakanishi, M.Sakurai, H.Nakagawa: Effect of smoke-free medical
school on smoking behavior of medical students, Japanese Journal of Public Health., 55:647-654, 2008 (inJapanese) .

Reviews
0800C001

Y.Yasui, M.Kim, T.Tanaka: PPAR ligands for cancer chemoprevention, PPAR Res., 2008:548919, 2008.

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Short Communications
0800E001

M.Nishijo, S.Maruzeni, K.Tawara, T.Kido, Nhu.DD, Naganuma.R, H.Suzuki, Hung.TM, Dung.PT, Thom.LH,
H.Nakagawa: Porychlorinated-dibenzo-p-dioxins/Furans and pregnancy outcome among vietnamese women living
in a herbicide sprayed area, Organohalogen Compounds., 70:1882-1885, 2008.

0800E002(T.Kido), R.Naganuma, H.Suzuki, Nhu.DD, K.Saito, M.Nishijo, H.Nakagawa, K.Tawara, Hung.NN, Thom.LH,
Dung.PT: The relationship between visualacuity and dioxin levels of breast milk in the herbicide sprayed and nonsprayed areas in vietnam, Organohalogen Compounds., 70:550-553, 2008.

Presentations at Conference
International Conference (Presentations)
0800I001

0800I002

高田尊信, 高野文英, 中村有香, 石垣靖人, 太田富久: Aqueous extract of peanut coat and its main constituentprocyanidin A1 suppress serum IgE and IgG1 levels in mice-immunized with ovalbumin, The 4th KSP-JSP-CCTNM
Joint Symposium on Pharmacognosy, (大韓民国江原道江陵市, '08.06)，The 4th KSP-JSP-CCTNM Joint
Symposium on Pharmacognosy, 209, 2008.
(辰野貴則), 高田尊信, 石垣靖人, 高野文英, 太田富久: Proanthocyanidin-enriched fraction isolated from

Diospyros kaki peel inhibited melanogenesis in culutured human HMV-2 cells, The 4th KSP-JSP-CCTCCM Joint
Symposium on Pharmacognosy, (江陵, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy,
210, 2008.
0800I003(三谷 薫), 高田尊信, 辰野貴則, 伊達絢一郎, 太田奈津子, 矢萩信夫, 矢萩れみ子, 石垣靖人, 高野文英, 太
田富久: The liquind culuture filtrates of entomogenous fungs Paecilomyces tenuipes and its glycoprotein
constituent protects against anemia in mice-treated with 5-fluorouracil, The 4th KSP-JSP-CCTCCM Joint
Symposium on Pharmacognosy, (江陵, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy,
207, 2008.

0800I004(伊達絢一郎), 高田尊信, 辰野貴則, 石垣靖人, 高野文英, 太田富久: N-glycory neuraminic acid fromedible/toxic mushroom Pleurocybella porrigens, The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy,(江陵, '08.06)，The 4th KSP-JSP-CCTCCM Joint Symposium on Pharmacognosy, 131, 2008.

－ 129 －

0900

Division of Cell Medicine

Faculty
Title

Name

Field of Specialization

FUJIKAWA Kohzaburo polyploid cells, cell cycle,transformation
MIYAGOSHI Minoru

Cell biology

Keywords of Research
polyploid cells, polyploidization, Meth-A cells, V79 cells, triploid cells, tetraploid cells, octaploid cells, H-1(ES)cells

Outline of Research
Study of polyploid cells

Publications
Originals
0900B001

X.Luo, K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi: Tetraploid-diploid transition of tetraploid H-1 (ES)cells in L15F10 medium without leukemia inhibitory factor, J. Kanazawa. Med. Univ., 33:107-111, 2008.

0900B002

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi, X.Luo: Alteration and preservation of cellular characteristics inlong-term culture of tetraploid H-1(ES) cells, Hum. Cell., 21:18-27, 2008.

0900B003

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi, X.Luo: Cell proliferation of diploid and tetraploid H1(ES) cells
in L15F10 medium without leukemia inhibitory factor, Cytologia (Tokyo), 73:259-268, 2008.

Reviews
0900C001

K.Fujikawa-Yamamoto: A new hypothesis for the genome structure of mammalian cells I - A fractal sturucture
model -, Cytometry Res, 18:57-64, 2008 (in Japanese) .

0900C002

K.Fujikawa-Yamamoto: A new hypothesis for the genome structure of mammalian cells II -Development topolyploid cells -, Cytometry Res, 18:65-71, 2008 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0900I001

Kohzaburo Fujikawa-Yamamoto, Minoru Miyagoshi, Hiroko Yamagishi, Xianwen Luo: Alteration and preservationof cellular characteristics in long-term culture of mouise tetraploid H-1 (ES) cels, 24th International Congress ofInternational Society for Analytical Cytology, (Budapest (Hungary), '08.05).

－ 130 －

0910

Division of Advanced Medicine

Faculty
Title

Name

Field of Specialization

MATSUI Shinobu

Clinical cardiology

TOMOSUGI Naohisa

Clinical Proteomics

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Keywords of Researchheart failure, cardiomyopathy, nerohumoral factor, immunity, autoantibody, spermatogenesis, cell cycle, epigenetics,
endocrine disruptors, meiosis

Outline of Research
1.Myocardial injury due to autoimmunity against G-protein-coupled receptor. Growing evidence suggested that G-proteincoupled receptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated
cardiomyopathy. Our study showed that specific removal of anti-G-protein coupled receptor autoantibodies improved
cardiac structure and function in experimental autoimmune cardiomyopathy.
2.Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.
However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has beendeveloped. Here, we employed surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOFMS) to analyze the expression of serum hepcidin in hemodialysis patients. Hepcidin-25 was found to accumulate in theserum of hemodialysis patients; this could contribute to the pathogenesis of renal anemia by decreasing the available ironfor hematopoiesis.
3.Histone modifications in meiotic prophase of spermatogenesis.

Publications
Originals
0910B001

Z-P.Zong, S.Matsui, J-F.Han, S.Katsuda, ML.Fu: Involvement of thymus in amiodarone-treated autoimmune
myocarditis in rats, Int. J. Cardiol., 125:122-129, 2008.

0910B002(H.Kijima), T.Sawada, N.Tomosugi, K.Kubota: Expression of hepcidin mRNA is uniformly suppressed inhepatocellular carcinoma, BMC Cancer, 8:167, 2008.

0910B003(T.Takata), T.Taanaka, N.Yahagi, R.Yahagi, H.Tsuchida, Y.Ishigaki, N.Tomosugi, S.Fushiya, F.Takano, T. Ohta:
The liquid culture filtrates of entomogenous fungus Paecilomyces tenuipes and its glycoprotein constituent protects
against anemia in mice treated with 5-fluorouracil, Biol.Pharm.Bull., 31:1565-1573, 2008.

0910B004(J-l.Wu), S.Matsui, Z-P.Zong, K.Nishikawa, B-G.Sun, S.Katsuda, M.Fu: Amelioration of myocarditis by statin
through inhibiting cross-talk between antigen presenting cells and lymphocytes in rats, J. Mol. Cell. Cardiol.,
44:1023-1031, 2008.

0910B005(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

0910B006(N.Fujita), R.Sugimoto, S.Motonishi, N.Tomosugi, H.Tanaka, M.Takeo, M.Iwasa, Y.Kobayashi, H.Hayashi,
M.Kaito, Y.Takei: Patients with chronic hepatitis C achieving a sustained virological response to peginterferon andribavirin therapy recover from impaired hepcidin secretion, J. Hepatol., 49:702-710, 2008.

－ 131 －

Case Reports
0910D001(H.Suzuki), F.Ito, H.Nakazawa, Y.Maeda, K.Yoshida, H.Tomoe, N.Tomosugi: Perioperative management in a
maintenance hemodialysis patient with congenital antithrombin Ⅲ deficiency undergoing surgery for renal cell
carcinoma, J. Jpn. Soc. Dial. Ther., 41:641-645, 2008 (in Japanese) .

Short Communications
0910E001(J.Kanda), C.Mizumoto, H.Kawabata, H.Tsuchida, N.Tomosugi, K.Matsuo, T.Uchiyama: Serum hepcidin level anderythropoietic activity after hematopoietic stem cell transplantaion, Haematologica., 93:1550-1554, 2008.

Presentations at Conference
International Conference (Key Note Lecture)
0910G001

N.Tomosugi: Proteomics for molecular diagnostics, 15th Congress of the FAOPS 2008, (Nagoya, '08.05).

International Conference (Presentations)
0910I001

N.Tomosugi, K.Kitagawa, H.Tsuchida, H.Umehara: Identification and quantification of tear proteins in sjogren's,
HUPO 2008 'th WORLO CONGRESS, (Amsterdam, '08.08).

0910I002

H.Yokoyama, M.Asaka, S.Kimura, H.Atsumi, J.Imura, Y.Chikazawa, M.Nakagawa, H.Okuyama, H.Yamaya,
N.Tomosugi: Statins preserved the function of transplanted kidneys under controlled blood pressure, Renal Week
2008 ASN`s 41st Annual Meeting ＆Scientific Exposition, (Philadelphia, '08.11)，J.Am.Soc.Nephrol, 19:682A,
2008.

0910I003(J.Kanda), C.Mizumoto, H.Kawabata, T.Ichinohe, H.Tsuchida, N.Tomosugi, K.Matsuno, T.Kondo, T.Ishikawa,
T.Uchiyama: Clinical significance of serum hepcidin-25 levels on early treatment-related complications after
hematopoietic stem cell transplantation, 50th annual meeting and exposition of the American Society of
Hematology, (San Francisco, '08.12)，Blood (ASH Annual Meeting Abstracts), 122:1160, 2008.

0910I004(J.JC.Kroot), E.HJM.Kemna, S.Bansal, M.Busbridge, N.Campostrini, D.Girelli, R.C.Hider, V.Koliaraki,
A.Manalaki, G.Olbina, N.Tomosugi, C.Tselepis, D.G.Ward, T.Ganz, J.CM.Hendriks, D.W.Swinkels: Results of thefirst international round robin for the quantification of urinary and plasma hepcidin: need for sandardization, 50th
annual meeting and exposition of the American Society of Hematology, (San Francisco, '08.12)，Blood (ASH
Annual Meeting Abstracts), 112:120, 2008.

－ 132 －

0920

Division of Molecular Oncology and Virology

Faculty
Title(Additional Post)

Name

Field of Specialization

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

MOTOO Yoshiharu

Clinical Oncology,Gastroenterology,Cancer Cell Biology

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

MURAKAMI Manabu

Ｐａｔｈｏｇｅｎｉｃｉｔｙ ｏｆ ｆｌａｖｉｖｉｒｕｓ,isdation from the field-collectedmosquitoes

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, hepatitis C virus, flavivirus, Japanese encephalitis
virus, virus replication, RhoGDI, Rho family, Eomes, epithelial/mesenchymal, nonstructural protein NS3, RNA synthesis,
transfection, persistent infection, RNAi

Outline of Research
Molecular analyses of virus replication, carcinogenesis and metastasis

Publications
Originals
0920B001(W.Sun), L.Dong, K.Kaneyama, T.Takegami, N.Segami: Bacterial diversity in synovial fluids of patients with TMD
determined by cloning and sequencing analysis of the 16S ribosomal RNA gene, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 105:566-571, 2008.

0920B002

M.Maeda, M.Murakami, T.Takegami, T.Ota: Promotion or suppression of experimental metastasis of B16 melanoma
cells, Toxicol. Appl. Pharmacol., 229:232-238, 2008.

0920B003(K.Wakabayashi), M.Komatsu, M.Murakami, I.Hori, T.Takegami: Morphology and gene analysis of hybrids between
two congeneric sea stars with dfferent modes of development, Biol. Bull., 215:89-97, 2008.

0920B004

J.Yamakawa, Y.Ishigaki, F.Takano, T.Takahashi, J.Yoshida, J.Moriya, T.Takata, T.Tatsuno, K.Sasaki, T.Ohta,
T.Takegami, F.Yoshizaki: The kampo medicines orengedokuto, bofutsushosan and boiogito have different activities
to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles,
Biol.Pharm.Bull., 31:2083-2089, 2008.

0920B005(A.Nagao), X.Zhao, T.Takegami, H.Nakagawa, S.Matsui, T.Matsunaga, Y.Ishigaki: Multiple shRNA expressions in asingle plasmid vector improve RNAi against the XPA gene, Biochem. Biophys. Res. Commun., 370:301-305, 2008.

Presentations at Conference
International Conference (Presentations)
0920I001

T.Ota, M.Maeda, Z.-P.Zong, M.Murakami, T.Takegami, M.Tatsuka: Phosphorylation and localization of FAK in vSrc transformed fibroblast cells after anoikis induction., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

－ 133 －

0920I002

Z.-P.Zong, M.Maeda, M.Murakami, T.Takegami, M.Tatsuka, T.Ota: Effects of oral administration of lapachol on
experimental metastasis of B16 melanoma cells in mice., BIT Life Sciences' 1st Annual World Cancer Congress,(Shanghai, '08.06).

0920I003

T.Takegami, M.Murakami, M.Sato, T.Ota, Y.Ishigaki: Analysis of gene expression in Japanese encephalitis virus
infected cells using microarray., 15th International Congress of Virology, ( Istanbul, '08.08).

－ 134 －

0930

Division of Dermatomycology (Novartis Pharma)

Faculty
Title

Name

Field of Specialization(Additional Post)

MOCHIZUKI Takashi Medical mycology，Dermatomycosis(Additional Post)

KAWASAKI Masako

Medical mycology

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Publications
Originals
0930B001

M.Kawasaki, K.Anzawa, K.Takeda, H.Tanabe, T.Mochizuki, H.Ishizaki: Ｇｅｎｅｔｉｃ ａｎｄ ｐｈｅｎｏｔｙｐｉｃ ｖａｒｉａｔｉｏｎｓ
ａｍｏｎｇ F1 ｐｒｏｇｅｎｉｅｓ ｏｆ Ａｒｔｈｒｏｄｅｒｍａ ｂｅｎｈａｍｉａｅ, Jpn. J. Med. Mycol., 49：103-110, 2008.

0930B002

M.Kawasaki, K.Anzawa, A.Wakasa, K.Takeda, H.Tanabe, T.Mochizuki, H.Ishizaki, BM. Hemashettar: Different
genes can result in different phylogenetic relationships in Trichophyton species, Jpn. J. Med. Mycol., 49：311-318,
2008.

0930B003(H.Shinoda), K.Nishimoto, T.Mochizuki: Screening Examination of Trichonphyton tonsurans among Judo
Practitioners at the All Japan Inter High School Champioships, Saga 2007, Jpn. J. Med. Mycol., 49：305-309, 2008
(in Japanese) .

Reviews
0930C002

T.Mochizuki: The university network of education and technical support of treatment of fungal diseases fordermatologists, Jpn. J. Med. Mycol., 49：181-185, 2008 (in Japanese) .

0930C003

T.Mochizuki: Mycological tests, Nipponrinsho., 66：2319-2325, 2008 (in Japanese) .

－ 135 －

Case Reports
0930D001(S.Ohno), H.Tanabe, M.Kawasaki, Y. Horiguchi: Tinea corporis with acute inflammation caused by Trichophyton

tonsurans, J. Dermatol., 35：590-593, 2008.
0930D002

M.Terada, M.Hasei, S.Watanabe, T.Fujii, H.Tanabe, T.Mochizuki: A case of gefitinib (Iressa®）-induced eruption
with acantholysis, Skin research., 7：131-136, 2008 (in Japanese) .

0930D005

K.Takeda, T.Ushigami, J.Fujita, H.Tanabe, T.Mochizuki, T.Machi: A case of penis tuberculid with induratio penis
plastica, Skin research., 7：676-680, 2008 (in Japanese) .

0930D009(N.Umemoto), T.Demitsu, K.Sasaki, M.Kakurai, M.Hayashi, Y.Wada, M.Moriguchi, Y.Hiratsuka, E.Iida, R.Azuma,
M.Kawasaki, T.Mochizuki: Phaeohyphomycosis due to Exophiala jeanselmei in immunocompromised hosts - Reportof two cases, Jichi Medical School journal., 31：77-83, 2008 (in Japanese) .

Short Communications
0930E001

T.Mochizuki, M.Kawasaki, K.Anzawa, J.Fujita, T.Ushigami, K.Takeda, Ａ.Sano, Y.Takahashi, K.Kamei:
Epidemiology of sporadic (non-epidemic) cases of Trichophyton tonsurans infection in Japan based on PCR-RFLP
analysis of non-transcribed spaser region of ribosomal RNA gene, Jpn.J.Infect.Dis., 61：219-222, 2008.

Presentations at Conference
International Conference (Key Note Lecture)
0930G001

T.Mochizuki, K.Anzawa: Molecular diagnosis of superficial mycoses, 8th Asian Dermatological Congress, (Seoul,
Korea, '08.10).

International Conference (Synposium)
0930H001

T.Mochizuki: Molecular epidemiology of cutaneous fungal infection in Japan, 4th Congress of Asia Pacific Society
for Medical Mycology, (Seoul, Korea, '08.10).

－ 136 －

0970

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy(Additional Post)

KAWAKAMI Yutaka

cataract, thyroid ocular

YAMASHIRO Yoko

ｃataract，electromagnetic wave induced ocular tissue changes，
epidemiology

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
0970B001(R.P.Kowalski), E.G.Romanowski, F.S.Mah, H.Sasaki, M.Fukuda, Y.J.Gordpm: A comparison of moxifloxacin andlevofloxacin topical prophylaxis in a fluoroquinolone-resistant staphylococcus aureus rabbit model, Jpn. J.
Ophthalmol., 52:211-216, 2008.

0970B002(A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki: Computation of temperature elevation in rabbit
eye irradiated by 2.45-GHz microwaves with different field configurations, Health Phys., 92:134-144, 2008.

0970B003(A.Hirata), H.Sugiyama, M.Kojima, H.Kawai, Y.Yamashiro, O.Fujiwara, S.Watanabe, K.Sasaki: Computationalmodel for calculating body-core temperature elevation in rabbits due to whole-body exposure at 2.45 GHz, Phys.
Med. Biol., 53:3391-3404, 2008.

0970B004

M.Fukuda, H.Sasaki: Calculation of AQCmax:comparison of five ophthalmic fluoroquinolone solution, Curr. Med.
Res. Opin., 24:3479-3486, 2008.

0970B005

M.Fukuda, J.Takahashi, Y.Nishida, H.Sasaki: Intraocular penetration of astaxanthin in rabbit eyes, Journal of theeye., 25:1461-1464, 2008 (in Japanese) .

－ 137 －

Others
0970F001

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, A.Hirata, Y.Sakamoto, Y.Kawakami, S.Watanabe, K.Wake, M.Taki,
Y.Kamimura, H.Sasaki, K.Sasaki: Investigation of wavelength-specific characteristics of quasi- and millimeterwaves, URSI, KP214:1-4, 2008.

Presentations at Conference
International Conference (Presentations)
0970I001

M.Kojima, T.Sakai, Y.Yamashiro, Y.Suzuki, Y.Sakamoto, Y.Kawakami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of millimeter wave exposure through ocular temperature measurement andheat transportation, Association for Research in vision and Ophthalmology, (Florida, '08.04).

0970I002

H.Sasaki, N.Yamamoto, Y.Takashima, T.Yamaguchi, E.Shibuya, Y.Inomata, Y.Sakamoto, Y.Kawakami,
H.Nakaizumi, K.Sasaki: Higher-order aberrations in transparent crystalline lens japanese eye, Association for
Research in Vision and Ophthlalmology, (Florlda, '08.04).

0970I003

N.Fujita, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, N.Yamamoto, Y.Kawakami, K.Nagai, H.Nakaizumi, K.Sasaki:
Comparison of myopia induced by retrodots and nuclear cataract, Associatin for Research in Vision andOphthalmology, (Florida, '08.04).

0970I004

M.Fukuda, H.Sasaki, N.Takahashi, M.Yoshikawa, M.Kojima, K.Kitagawa, Y.Sakamoto, K.Sasaki: Development oftechnique to measure corneal resistance that can be used to evaluate corneal injury, Association for Research in
Vision and Ophthlalmology, (Florida, '08.04).

0970I005

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Protective effect of topical
5-S-GAD on UV-B- induced cataract in rats, Association for Research in Vision and Ophthalmology, (Florida,'08.04).

0970I006

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.lu, J.Zhang, K.Sasaki: Prevalence of pseudoexfoliation inchina, Association for Research in Vision and Ophthalmology, (Florida, '08.04).

0970I007

J.Qu, H.Sasaki, Y.Sakamoto, H.Nakaizumi, Y.Kawakami, K.Nagai, K.Sasaki: Influcence of capsular capture of
intraocular lens on ocular higher- order wavefront aberration, Association for Research in Vision andOphthalmology, (Florida, '08.04).

0970I008

Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, Y.Kawakami, J.Qu, K.Sasaki, H.Sasaki: Does corneal curvatureradius contribute to pathogenesis of pterygium? -A report from chinese ophtalmic surveys in Hainan and Shanxi,
Association for Research in Vision and Ophthalmology, (Florida, '08.04).

0970I009

M.Kojima, T.Sakai, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, Y.Kawanami, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Investigation of frequency specificity of Quasi and millimeter wave exposure through ocular temperature
measurement and heat transportation, The Bioelectromagnetics in Society 30th Annual Meeting, (San Diego,'08.06).

0970I010

H.Osada, Y.Yamashiro, R.Honda, Y.Sakamoto, K.Nagai, Y.Kawakami, K.Sasaki, H.Sasaki: Posterior capsule
opacifiation in rural areas of China, The 7ｔｈ Asian Cataract Research Conference in Conjunction with Cataract
Satellite Meeting of the 18th International conference for Eye Research and the 11th Conference of Chinese
Cataract Society, (Xi'an, '08.09).

0970I011

H.Sasaki: High order aberration of phakic and pseudophakic eyes, The 7th Asian Cataract Research
Conference in Conjunction with Cataract Satelite Meeting of the 18th International Cngerence for Eye
Research and the 11th Conference of Chinaese Cataract Society Clincal Warkshop, (Xi'an, '08.09).

0970I012

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: Effect factors oflens thickness, The 7th Asian Cataract Research Conference in Conjunction with Cataract Satellite Meeting of the
18th international Conference for Eye Research and the 11th Conference of Chinese Cataract Society Clinical
Warkshop, (Xi'an, '08.09).

－ 138 －

0970I013

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract, The 7th Asina Cataract Research Conference in Conjunction with Cataract satellite Meeting of the 18th
International Conference for Eye Research and the 11th Conference of Chinese Cataract Society, (Xi'an, '08.09).

0970I014

M.Fukuda, H.Sasaki: Vitreous and aqueous penetration of orally and topically administered moxifiloxacin,
International Society of Ocular Toxiology 11th Congress ISOT 2008, (September, '08.09).

0970I015

Y.Sakamoto, H.Sasaki, E.Shibuya, N.Yamamoto, Y.Inomata, M.Tarura, K.Sasaki: Visible light abeorption band ofspectacle lesn and contrast sensitivity function, The 7th Asian Cataract Research Conference in Conjunction with
Cataract Stellite Meeting of the 18th International Conference for Eye Research and the 11th Conference ofChinese Cataract Society, (Xi'an, '08.09).

－ 139 －

9050

Center for FDD-MB

Faculty
Title

Name

Field of Specialization

TAKABAYASHI Haruo fetal medicine, DNA medicine

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's
health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology－ 140 －

Ｈｉｍｉ Ｍｕｎｉｃｉｐａｌ Ｈｏｓｐｉｔａｌ

9100Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery.

AKAMARU Tomoyuki Orthopaedic Surgery
KUZAWA Yutaka

Cardio Vascular Surgery

NAKASHIMA Aiko

Radioloy

NAKATANI Yusuke

Ophthalmology

FUCHIZAWA Tatsuya Pediatrics
MATSUI Toshiaki

Oral & Maxilofacial Surgery

MURATA Shuichi

Thoracic Surgery

SAITOH Atsushi

Nephrology

TAKATA Hideo

Orthopaedic Surgery

WATANABE Kimimasa Orthopaedic Surgery
MUKAI Hirokado

Oncology Surgery

YAMADA Tsuyoshi

First aid & Emergency Medicene , Surgery of Digestive Diseases

YAMAMOTO Junko

Pediatrics－ 141 －

Kanazawa Medical University
Research Activities and Publications 2008
Published December, 2009
Issuer : Yuichi Yamada
Editer : Takayuki Nojima
Publishing Office : Kanazawa Medical University Publication Office
1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa-ken, Japan, 920-0293
Tel+81 76 286 2211(Representative)

Printing office : HASHIMOTO KAKUBUNDO Co., LTD