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I
Code

Department

Liberal

N
Page

Arts

0010

Department of Human Science (Humanities) ･･･1

0030

Department of Human Science (Mathematics) ･･20040

Department of Life Science

D

E

X

Code

Department

Page

0250

Department of Legal Medicine ･･･････････････35

0260

Department of Medical Education ････････････36

Clinical Medicine
0300

Department of Cardiovascular Medicine ･･･････37

Department of Life Science

0310

Department of Respirolgy (Respiratory Medicine)･･39(Natural Science:Chemistry) ･･････････････････40320

Department of Gastroenterology ･････････････41

Department of Life Science

0330

Department of Nephrology ････････････････････45(Natural Science:Biology) ･････････････････････50340

Department of Endocrinology and Metabolism･･･47

Department of Human Science

0350

Department of Hematology and Immunology ･･･49(Foreign Languages:English) ･･････････････････60360

Department of Neurology ･････････････････････52

Department of Human Science

0370

Department of Geriatric Medicine･･････････････54(Foreign Languages:German) ･･････････････････70380

Department of Pediatrics ･････････････････････56

0081 Department of Human Science (Linguistics) ･････80390

Department of Neuropsychiatry ･･･････････････58

0090 Department of Life Science (Physical Education) ･･･90400

Department of Diagnostic and Therapeutic(Natural Science:Physics)
0050

0060

0070

0080

････････････････････3

Radiology ･･･････････････････････････････････60
0410

Department of Cardiovascular Surgery ･･････62

Department of Molecular and Cell Structural

0420

Department of Surgical Oncology ････････････63

Science (Anatomy Ⅰ) ･･･････････････････････110430

Department of Orthopedics Surgery ･･･････････64

Department of Molecular and Cell Structural

0440

Department of Neurosurgery ･････････････････68

Science (Anatomy Ⅱ) ････････････････････････130450

Department of Plastic and Reconstructive

Basic
0100

0110

0120

Medicine

Department of Physiology Ⅰ ･････････････････14

Surgery ････････････････････････････････････70

0130 Department of Physiology Ⅱ ･･････････････････160460

Department of Pediatric Surgery ･･････････････72

0140

Department of Biochemistry Ⅰ ･･･････････････18

0470

Department of Ophthalmology ････････････････73

0150

Department of Biochemistry Ⅱ ･･････････････190480

Department of Otolaryngology ････････････････76

0160

Department of Pharmacology ････････････････20

0490

Department of Dermatology ･･･････････････････78

0170

Department of Oncologic Pathology ･･････････21

0500

Department of Urogenital Surgery ････････････81

0180

Department of Pathophysiological and0510

Department of Obstetrics and Gynecology ･････83

Experimental Pathology ････････････････････230520

Department of Anesthesiology and0190

Department of Microbiology ･････････････････25

0200

Department of Fundamental Research for CAM ･･26

0530

Department of Oral and Maxillofacial Surgery･･86

0210

Department of Medical Zoology ･･････････････27

0550

Department of Emergency Medicine････････････87

0220

Department of Pathology and Laboratory

0560

Department of Medical Oncology ･･････････････88

Medicine ･･･････････････････････････････････28

0570

District medical ･････････････････････････････90

Department of Social and Environmental

0610

Health Management Center･･････････････････91

Medicine ･･･････････････････････････････････30

0620

Department of Pathology ･････････････････････93

0240 Department of Epidemiology and Public Health ･･･32

0630

Department of General Internal Medicine ･･････94

0230

Perioperative Medicine ･･････････････････････85

CodeDepartment

Page

0640

Endoscopy Center ･･･････････････････････････95

0650

Department of Rehabilitation Medicine ･･･････96

0660

Department of Respirology (Thoracic Surgery) ･･･97

0670

Lifestyle-related Diseases Center ････････････100

0680

Medical Genetic Center ･････････････････････101

0690

Department of Endoscopy ･･･････････････････102

0700

Multidiscciplinary Cancer Center ････････････103

Schoolof

Nursing

8010

Basic Nursing ･････････････････････････････105

8030

Psychiatric and Mental Health Nursing ･･････106

8040

Adult Nursing

8050

Nursing of the Elderly ･･････････････････････109

8060

Child Nursing ･････････････････････････････110

8070

Maternity Nursing ･････････････････････････111

8080

Community Nursing

8090

Home Care Nursing ････････････････････････114

8100

Human Science ････････････････････････････115

MedicalResearch････････････････････････････108･･････････････････････112

Institute/ Center for FDD-MB

0710

Medical Research Institute･ ･･････････････････119

0740

Division of Human Genetics (Biochemistry) ･･120

0750

Division of Human Genetics (Clinical Medicine) ･121

0770

Division of Core Facility (Radioisotope Center) ･･122

0780

Division of Core Facility(Experimental Animal Center) ･･････････････124

0800

Division of Core Facility(High-Tech Research Center) ･･･････････････125

0900

Division of Cell Medicine ･･･････････････････128

0910

Division of Advanced Medicine ･･････････････129

0920

Division of Molecular Oncology and Virology ････131

0930

Division of Dermatomycology(Novartis Pharma) ･････････････････････････133

0970

Division of Vision Research forEnvironmental Health ･･････････････････････135

9050

Center for FDD-MB ･････････････････････････138

CodeDepartment

Page

Himi Municipal Hospital
9100

Himi Municipal Hospital ････････････････････139

Liberal Arts

0010

Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

HIRAGUCHI Tetsuo

environmental-ethnoarchaeology， peace studies．

TAKEDA Koichi

Philosophy , History of logic

Keywords of Researchzoo-archaeology, cetacean, dolphin, whale, faunal remains, environmental archaeology, whaling, ancient diet, Palaeolithic
period, Jomon period, ethno-archaeology, anthropological education, peace study, logic, metaphysics, form, content,
predicate, category, deduction, induction, matter, being, substance, definion

Outline of Research
Hiraguchi:Environmental and ethnological archaeology (especially prehistoric whaling), anthropological education for medical
students, and peace studies.
Takeda:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

Publications
Originals
0010B001

Koichi TAKEDA: Per Se Being in Aristotle's Metaphysics, Mem. Lib. Kanazawa Med. Univ., 37:1-10, 2009 (inJapanese) .

－ 1 －

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field

Publications
Originals
0030B001(Y.Koyama), K.Yoshino: Prime divisors of the class number of the real prth cyclotomic field and characteristic
polynomials attached to them, RIMS Kôkyûroku Bessatsu., B12:149-172, 2009.

0030B002

H.Matsuda, S.Yorozu: On generalized mannheim curves in euclidean 4-space, Nihonkai Math. J., 20:33-56, 2009.

0030B003

K.Yoshino: The determination of the n-cyclotomic fields with h-n=n, where n is an odd integer, Mem. Lib.
Kanazawa Med. Univ., 37:11-24, 2009 (in Japanese) .

－ 2 －

0040

Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Keywords of Researchpiriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording

Outline of Research
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: In order that the student who majors in life science may deepen an understanding of a lecture, and in order toenable independent learning, we are developing the stude support which used a demonstration experiment and intranet.

Publications
Originals
0040B001

K.Nakamura: Teaching Physics at Kanazawa Medical University, Mem. Lib. Kanazawa Med. Univ., 37:25-31, 2009
(in Japanese) .

－ 3 －

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

－ 4 －

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

HORI Isao

Development of ascidians

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell, lectin, galectin, β-galactoside, Xenopus, development, placenta, trophoblast

Outline of Research
１）Functional analysis of Galectins, a family of ・-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the formation of placenta.
c）Regulations of virus growth by Galectins.
２）Electron microscopic analysis of the mechanisms of regeneration of planarians.

Publications
Originals
0060B001

H.Shoji, L.Deltour, T.Nakamura, S.Tajbakhsh, F.Poirier: Expression pattern and role of Galectin1 during earlymouse, Dev. Growth Differ., 51:607–615, 2009.

－ 5 －

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

SHIBUYA Yoshiho

English linguistics，Phonetics

KAKIZAKI KenichiContemporary Jewish American Authors' Works

BURKE STEVEN
ThomasEnglishKeywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation

Outline of Research
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.

Books
0070A001

K.Kakizaki: Projective Identification in The Victim, The Psychoanalytic Study of English Literature, 423-37,
Tokyo, 2009.

Publications
Originals
0070B001

K.Kakizaki: Rediscovering the Inner Girl in A Theft, Shlemiel., 8:57-69, 2009.

0070B002

K.Kakizaki: Healing from Childhood Psychological Maltreatment in "What Kind of Day Did You Have.", Journal of
English Language and Literature, 57:15-30, 2009.

0070B003

K.Kakizaki: Strength of Love in "A Worn Path.", Mem. Lib. Kanazawa Med. Univ., 37:33-44, 2009.

0070B004

K.Kakizaki: Father's Legacy in "Something to Remember Me By.", Mem. Lib. Kanazawa Med. Univ., 37:45-55,
2009.

－ 6 －

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

HARA Akira

Austria literature led by Hofmannsthal

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

Publications
Originals
0080B001

Munehiro KOUCHI: Wilhelm Mommsen : Die politischen Anschauungen Goethes(3), Mem. Lib. Kanazawa Med.
Univ., 37:67-89, 2009 (in Japanese) .

0080B002

Munehiro KOUCHI: Der Damon und das Damonische bei Goethe, Mem. Lib. Kanazawa Med. Univ., 37:57-66,
2009 (in Japanese) .

－ 7 －

0081

Department of Human Science (Linguistics)

Faculty
Title

Name

Field of Specialization

AINODA Noriko

How do the Japanese medical students acquire medical terms in
English as a second language? My research focuses on this question
using both linguistic and phonetic knowledge, with the research
evidence in cognitive science.

Keywords of Researchlinguistics, phonetics, teaching of English, medical education

Outline of Research
Metacognition is an essential factor for lifelong learning of which skills should be fostered during undergraduate medical
education. To seek longitudinal changes in metacognitive processes through problem-based learning (PBL), the year 3
students' reflective comments were categorically analized. The results showed that "knowledge of ignorance," one ofmetacognitive skills, could be fostered in PBL.

－ 8 －

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

UEDA Fumio

Physical strength and a study about the athletic capability，Abasketball competition

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Yamashina : To find an effective way to prevent falling ,I have studied the ability to sustain a standing posture and fallingmechanism.
To clarify the association between antigravity muscles and the ability to sustain static and active standing posture.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.

－ 9 －Basic Medicine

0100

Department of Molecular and Cell Structural Science (Anatomy Ⅰ)

Faculty
Title

Name

Field of Specialization

HATTA Toshihisa

developmental biology, neuroscience

HIGASHI Nobuaki

macroscopic anatomy,embryology.

SHIMADA Hiroki

Medical science of free radical

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

H.Shimada, K-I.Hirai, E.Simamura, T.Hatta, H.Iwakiri, K.Mizuki, T.Hatta, T.Sawasaki, S.Matsunaga, Y.Endo,
S.Shimizu: Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependentoxidoreductase, J. Biol. Chem., 284: 28642-28649, 2009.

0100B002(M.Daisu), T.Hatta, Y.Sakurai-Yamashita, T.Nabika, K.Moritake: Quantitative analysis of delayed neuronal deathin the hippocampal subfields of SHRSP and SHR, Cell. Mol. Neurobiol., 29:557-562, 2009.

0100B003

N.Higashi, H.Shimada, E.Simamura, T.Hatta: Branching patterns of the celiac artery as the hepato-gastro-splenic
trunk, Acta Anatomica Nipponica., 84:7-10, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0100I001

J. Hatta, T.Hatta, S.Miyagawa, Y.Kitahara, T.Hirota, K.Anzawa, T.Mochizuki: Quantitative image analysis ofeffects of antimycotic agents on the hyphal growth in Trichophyton rubrum, The 17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

－ 11 －

0100I002

T.Hatta, E.Simamura, H.Shimada, M.Uchishiba, N.Higashi: Maternal leukemia inhibitory factor enhances
proliferation of neuronal progenitors of forebrain in rat fetuses., Society for NEUROSCIENCE 2009, (Chicago,'09.10).

0100I003

E.Simamura, H.Shimada, N.Higashi, H.Otani, T.Hatta: Leukemia inhibitory factor level in cerebrospinal fluid iselevated via placental adrenocorticotropic hormone in rat fetuses., Society for NEUROSCIENCE 2009, (Chicago,'09.10).

－ 12 －

0110

Department of Molecular and Cell Structural Science (Anatomy Ⅱ)

Faculty
Title

Name

Field of Specialization

SHINOHARA
Harumichi

gross anatomy,embryology,lymphatic vessels,microscopy.

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve.
YASUTAKA Satoru

gross anatomy,central nervous system.

KOMINAMI Rieko

immunocytochemistry,pituitary,cell proliferation,electron microscopy.

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

Publications
Reviews
0110C001

H.Shinohara: Fundamentals of white matter dissection, Japanese journal of neurosurgery., 18:749-754, 2009 (inJapanese) .

Case Reports
0110D001(H.Takiguchi), T.Shimokawa: A clinical and anatomical study on the causes of temporomandibular disorders typeⅢ, J.J.A.O.H, 15:1-4, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0110I001

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, R.Kominami, H.Shinohara, T.Matsumoto: Glucocorticoid
induces micro-fat embolism in the rabbit: a scanning electron microscopic study, Association Research Circulation
Osseous 15th International Symposiumon Bone Circulation (ARCO 2009), (Yokohama, '09.11)，ARCO 2009
Program, 47, 2009.

－ 13 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

KATO Nobuo

Brain Science

SUGAI Tokio

Neurophysiology

YAMAMOTO Ryo

Neuroscience

ADACHI Hiroshi

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the output signal is released or not. Neurons areconnected to each other by synapses to build neuron network, which underlies brain function. Our primary research interest
is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron excitability and synaptic efficiency.
In particular, we are interested in studying in vitro how the versatile intracellular messenger calcium ion mediates a numberof signals differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As anotherresearch topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Reviews
0120C001

N.Kato: Neurophysiological mechanisms of electroconvulsive therapy for depression., Neurosci. Res., 64:3-11,
2009.

Presentations at Conference
International Conference (Presentations)
0120I001

H.Yoshimura, T.Sugai, N.Segami, N.Kato: Input frequency-and NMDA receptor activity-dependent determinationof signal-traveling routes between primary and secondary visual cortices, The 36th International Congress ofPhysiological Sciences, (Kyoto, '09.07)，"J.Physiol. Sci. Suppl,", 59:S284, 2009.

0120I002

T.Sugai, R.Yamamoto, Y.Ueta, H.Yoshimura, N.Kato: The endopiriform nucleus functionally connects the olfactoryand gustatory information the rat, The 36th International Congress of Physiological Sciences, (Kyoto, '09.07)，
J.Physiol. Sci. Suppl, 59:S202, 2009.

－ 14 －

0120I003

R.Yamamoto, T.Sugai, Y.Ueta, N.Kato: Serotonergic modulation on the excitability of lateral amygdala neurons,
The 36th International Congress of Physiological Sciences, (Kyoto, '09.07)，J.Physiol. Sci. Suppl, 59:S288, 2009.

0120I004(K.Yamamoto), Y.Ueta, R.Yamamoto, N.Inoue, K.Inokuchi, N.Kato: Electroconvulsive stimulation blocks
intracellular amyloid-beta-mediated suppression of bk channels in neocortical pyramidal neurons, The 36th
International Congress of Physiological Sciences, (Kyoto, '09.07)，J.Physiol. Sci. Suppl, 59:S514, 2009.

－ 15 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

SHIBAMOTO
Toshishige

Circulatory Physiology

KURATA Yasutaka

Cardiac Electrophysiology

MIYAMAE Shunichi

Cardiac Electrophysiology

KAMIKADO Chiaki

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

W.Zhang, T.Shibamoto, S.Cui, H.Takano, Y.Kurata: 7-nitroindazole, but not L-name or aminoguanidine,
attenuates anaphylactic hypotension in conscious rats, Shock, 31:201-206, 2009.

0130B002

H.Takano, T.Shibamoto, W.Zhang, Y.Kurata, H.Toga: Hepatic microvascular pressure during anaphylactic shockin anesthetized rats, Microvasc. Res., 78:169-173, 2009.

0130B003

ZS.Zhao, T.Shibamoto, M.Tsutsumi, S.Cui, WM.Zhang, H.Takano, Y.Kurata: Mouse hepatic portal
venoconstrictive response to vasoconstrictors is much weaker than that in rat, J. Cardiovasc. Pharmacol., 54:421426, 2009.

0130B004(S.Koshida), Y.Kurata, T.Notsu, Y.Hirota, TY.Kuang, P.Li, U.Bahrudin, S.Harada, J.Miake, Y.Yamamoto,Y.Hoshikawa, O.Igawa, K.Higaki, M.Soma, A.Yoshida, H.Ninomiya, G.Shiota, Y.Shirayoshi, I.Hisatome: Stabilizing
effects of eicosapentaenoic acid on Kv1.5 channel protein expressed in mammalian cells, Eur. J. Pharmacol.,604:93-102, 2009.

－ 16 －

Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, W.Zhang, Y.Kurata: The pathophysiology of anaphylactic hypotension in rats, XXXVI International
Congress of Physiological Sciences (IUPS2009), (Kyoto, '09.07)，J Physiol Sci, 59 (Suppl 1): 498, 2009.

0130I002

W.Zhang, T.Shibamoto, Y.Kurata: Effects of β-adrenergic blockers on anaphylactic hypotension in conscious rats,
XXXVI International Congress of Physiological Sciences (IUPS2009), (Kyoto, '09.07)，J Physiol Sci, 59 (Suppl 1):498, 2009.

0130I003

Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto: Roles of hyperpolarization-activated current Ih in sinoatrial node
pacemaking: insights from bifurcation analysis of mathematical models, XXXVI International Congress ofPhysiological Sciences (IUPS2009), (Kyoto, '09.07)，J Physiol Sci, 59 (Suppl 1): 130, 2009.

0130I004(H.Matsuda), Y.Kurata, T.Shibamoto: α-adrenergic modulation of the sustained outward K+ currents in rat
ventricular myocytes, XXXVI International Congress of Physiological Sciences (IUPS2009), (Kyoto, '09.07)，J
Physiol Sci, 59 (Suppl 1): 254, 2009.

0130I005

T.Shibamoto, W.Zhang, Y.Kurata: Hepatic venoconstriction is involved in anaphylactic hypotension in animals of
various species, XXI World Allergy Congress, (Buenos Aires, '09.12)，2009.

－ 17 －

0140

Department of Biochemistry Ⅰ

Name

Field of Specialization

Faculty
Title

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins
MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

HASHIMOTO
Mitsumasa

Cell biology, DNA repair, Cell cycle, p53-binding proteins

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001(K.Watanabe), K.Iwabuchi, J.Sun, Y.Tsuji, T.Tani, K.Tokunaga, T.Date, M.Hashimoto, M.Yamaizumi, S.Tateishi:
RAD18 promotes DNA double-strand break repair during G1 phase through chromatin retention of 53BP1, Nucleic
Acids Res., 37:2176-2193, 2009.

－ 18 －

0150

Department of Biochemistry Ⅱ

Name

Field of Specialization

Faculty
Title

Molecular mechanisms of angiogenesis, Alternative ｍRNA
processing, MicroRNA function
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein
YONEKURA Hideto(Additional Post)

NAGAO Yosinobu

Spermatogenesis and epigenetics

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative ｍRNA processing

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications－ 19 －

0160

Department of Pharmacology

Faculty
Title

Name
NISHIO Matomo(Additional Post)

ISHIBASHI Takaharu
YOSHIDA Junko
NAKAMOTO Mihoko
ABE Fusae

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemPharmacology in cardiovascular system, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular system, Cancer chemotherapy
Ｐｈａｒmacology of cardiovascular drugs, Kinetics of NO-related
Compounds in cardiovascular systems, Cancer chemotherapy

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary circulation,
nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug,
proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

T.Ishibashi, N.Nishizawa, M.Nakamoto, S.Liu, M.Yang, T.Miwa, I.Shinkawa, J.Yoshida, T.Kawada, M.Nishio:
Arteriovenous differences in NO2- kinetics in anesthetized rabbits, Biol.Pharm.Bull., 32:399-404, 2009.

－ 20 －

0170

Department of Oncologic Pathology

Faculty
Title(Additional Post)

Name

Field of Specialization

TANAKA Takuji

Inhibition of carcinogenesis, Oncologic pathology of digestive organ,
Experimental pathology

SUGIE Shigeyuki

Experimental pathology, Oncologic pathology of digestive organ

KOHNO Hiroyuki

Experimental pathology,Tumor immunology

YASUI Yumiko

Lipids in carcinogenesis

OYAMA Takeru

Mechanisms of carcinogenesis

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Books
0170A002

T.Tanaka: Toxicological carcinogenesis, Encyclopedia of Cancer, 2nd Edition(Manfred Schwab), 3008-3010,
Springer-Verlag, Berlin, 2009.

Publications
Originals
0170B001

T.Tanaka, Y.Yasui, M.Tanaka, T.Tanaka, T.Oyama, KM Wahidur Rahman: Melatonin suppresses AOM/DSSinduced large bowel oncogenesis in rats, Chem. Biol. Interact., 177:128-136, 2009.

0170B002(M.Kim), S.Miyamoto, Y.Yasui, T.Oyama, A.Murakami, T.Tanaka: Zerumbone, a tropical ginger sesquiterpene,
inhibits colon and lung carcinogenesis in mice, Int. J. Cancer., 124:264-271, 2009.

0170B003(M.Shimizu), Y.Shirakami, J.Iwasa, M.Shiraki, Y.Yasuda, K.Hata, Y.Hirose, H.Tsurumi, T.Tanaka, H.Moriwaki:
Supplementation with branched-chain amino acids inhibits azoxymethane-induced colonic preneoplastic lesions inmale C57BL/KsJ-db/db mice, Clin. Cancer Res., 15:3068-3075, 2009.

－ 21 －

0170B004(M.Yasuda), T.Nishizawa, H.Ohigashi, T.Tanaka, D.X.Hou, N.H.Colburn, A.Murakami: Linoleic acid metabolite
suppresses skin inflammation and tumor promotion in mice: possible roles of programmed cell death 4 induction,
Carcinogenesis, 30:1209-1216, 2009.

0170B005(T.Toyoda), T.Tsukamoto, S.Takasu, N.Hirano, H.Ban, L.Shi, T.Kumagai, T.Tanaka, M.Tatematsu1: Pitavastatin
fails to lower serum lipid levels or inhibit gastric carcinogenesis in Helicobacter pylori-infected rodent models,Cancer Prev. Res. (Phila. Pa)., 2:751-758, 2009.

0170B006(K.Yoshimi), T.Tanaka, A.Takizawa, M.Kato, M.Hirabayashi, T.Mashimo, T.Serikawa, T.Kuramoto: Enhanced
colitis-associated colon carcinogenesis in a novel Apc-mutant rat, Cancer Sci., 100:2022-2027, 2009.

0170B007

T.Oyama, Y.Yasui, S.Sugie, M.Koketsu, K.Watanabe, T.Tanaka: Dietary tricin suppresses inflammation-relatedcolon carcinogenesis in male Crj: CD-1 mice, Cancer Prev. Res. (Phila. Pa)., 2:1031-1038, 2009.

0170B008

Y.Yasui, T.Tanaka: Protein expression analysis of inflammation-related colon carcinogenesis, J Carcinog., 8:10,
2009.

Reviews
0170C001

Y.Yasui, M.Kim, T.Oyama, T.Tanaka: Colorectal carcinogenesis and suppression of tumor development by
inhibition of enzymes and molecular targets, Current Enzyme Inhibition., 5:1-26, 2009.

0170C002(D.W.Rosenberg), C.Giardina, T.Tanaka: Mouse models for the study of colon carcinogenesis, Carcinogenesis,
30:183-196, 2009.

0170C003

T.Oyama, Y.Yasui, T.Tanaka: Breast cancer chemoprevention: current perspectives, Current Enzyme Inhibition.,
5:198-208, 2009.

0170C004

T.Tanaka: Colorectal carcinogenesis: Review of human and experimental animal studies, J Carcinog., 8:5, 2009.

0170C005

T.Oyama, Y.Yasui, S.Sugie, T.Tanaka: Preclinical assays for identifying cancer chemopreventive phytochemicals,
Scholarly Research Exchange., Article ID 475963・doi: 10.3814, 2009.

Presentations at Conference
International Conference (Presentations)
0170I001

T.Oyama, Y.Yasui, M.Kamide, S.Yamamoto, S.Sugie, T.Tanaka: A flavone, tricin, suppresses colitis-associatedmouse colon carcinogenesis, 9th Korea-Japan Symposium on Cacner and Ageing Research, (South Korea, '09.03).

0170I002(M.Kim), S.Miyamoto, Y.Yasui, T.Oyama, A.Murakami, S.Sugie, T.Tanaka: Dietary zerumbone inhibits colon andlung carcinogenesis in mice, 9th Korea-Japan Symposium on Cacner and Ageing Research, (South Korea, '09.03).

0170I003

T.Tanaka: Preclinical bioassays for chemoprevention studies on inflammation- and obesity- related coloniconcogenesis, International Conference on Dietary and Chemical Cancer Prevention, (Taipei, '09.04).

－ 22 －

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

KATSUDA Shogo

Vascular pathology, Pathophysiology of ECM

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

SATO Katsuaki

Neuropathology

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

J.Xu, Z.Wang, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma: Endogenous catecholamine stimulates alveolar
fluid clearance in rats with acute pancreatitis, Respirology, 14:195-202, 2009.

0180B002

T.Lihua, Y.Sakai, K.Iwai, S.Katsuda: Effect of collagen tripeptide of typeⅠcollagen on migration, proliferation andcollagen synthesis of human aortic smooth muscle cells, J. Kanazawa. Med. Univ., 34:93-100, 2009.

0180B003

K.Higashi, T.Sakuma, K.Ito, S.Niho, Y.Ueda, T.Kobayashi, R.Sekiguchi, T.Takahashi, T.Kato, H.Tonami:
Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEAlevel:identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma, Eur.
J. Nucl. Med. Mol. Imaging, 36:373-381, 2009.

0180B004

R.Terauchi, K.Sato, M.Takenaka, M.Yamashita, Y.Asakura, M.Nakano, N.Kurose, H.Minato, T.Nojima:
Intracytoplasmic lumina of urothelial carcinoma in urine cytology, J. Jpn. Soc. Clin. Cytol., 48:12-16, 2009 (inJapanese) .

0180B005

N.Koizumi, T.Miyanaga, S.Kawakami, M.Shimasaki, Y.Ueda: Proliferetive and differentiative effects of basic
fibroblast grouwth factor(bFGF) on perichondium of rabbit's ear, Skin research., Special edition. 11：14-20, 2009
(in Japanese) .

－ 23 －

Case Reports
0180D001

K.Sato, Y.Ueda, K.Kawamura, K.Aihara, S.Katsuda: Plasmacytoid urothelial carcinoma of the urinary bladder: acase report and immunohistochemical study, Pathol. Res. Pract., 205:189-194, 2009.

0180D002

M.Sagawa, Y.Ueda, H.Sakuma, Y.Yoshimisu, F.Matsubara, T.Sakuma: Organizing pneumonia with an enlarging
tumor-like lesion:immunohistochemical study, Jpn. J. THORACIC CARDIOVASC. SURG., 57:433-436, 2009.

0180D003

M.Yamada, H.Shiroeda, S.Shiroeda, K.Sato, T.Arisawa, M.Tsutsumi: Cholangiocarcinoma producig parathyroid
hoemone-related peptide treated with chemoradiation usig gemcitabine and S-1, Intern. Med., 48:2097-2100,
2009.

－ 24 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

OHARA Yoshiro

Neurovirology，Neuroimmunology

HIMEDA Toshiki

Neurovirology

OKUWA Takako

Neurovirology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

N.Taniura, M.Saito, T.Okuwa, K.Saito, Y.Ohara: Different subcellular localization of Theiler's murine
encephalomyelitis virus leader proteins of GDVII and DA strains in BHK-21 cells, J. Virol., 83: 6624-6630, 2009.

0190B002

M.Saito, T.Matsuzaki, Y.Satou, J.Yasunaga, K.Saito, K.Arimura, M.Matuoka, Y.Ohara: In vivo expression of the
HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1
associated myelopathy/tropical spastic paraparesis (HAM/TSP), Retrovirology., 6:19, 2009.

Presentations at Conference
International Conference (Presentations)
0190I001

T.Okuwa, N.Taniura, M.Saito, K.Saito, Y.Ohara: Nonstructural proteins of Theiler's murine encephalomyelitis
virus (TMEV), leader (L) and L*, influence apoptotic cell death., 9th Internationnal Symposium on NeuroVirology,(Florida, '09.06).

0190I002

Y.Ohara, T.Okuwa, N.Taniura, M.Saito, K.Saito, RP.Roos: L* protein of Theiler's murine encephalomyelitis virus(TMEV) inhibits apoptosis induzed by leader (L) protein in BHK-21 cells, Neuroｓcience 2009, (Chicago, '09.10).

－ 25 －

0200

Department of Fundamental Research for CAM

Faculty
Title

Name

Field of Specialization

YAMAGUCHI Nobuo

Developmental immunology, Defense immunity, Tumor immunity,
Complementary & alternative medicine

SHIMIZU Shoji

Immunology, Protective immunology, Tumor immunology

MATSUBA Shintaro

Complementary & alternative medicine, Immunological pharmacology

SAKUMA Masahiro

Molecular and cellular immunology, Pathological examination studies,
Complementary & alternative medicine

Keywords of Researchpregnancy, maternal immunization, offspring, immune suppression, acquired immunodeficiency, immunomodulator, oral
immunity, herbal medicine, cytokine

Outline of Research
Our research is founded on immunology. To date, we have studied fields such as fetomaternal immunity, tumor immunity
and infectious immunity. With the graduate school reorganization in 2003, the name of the chair was changed with"Complementary and alternative medicine". Since then, we started the trial which verified alternative medicine of all thecountries of world by the immunological parameters. In order to achive these ends as effectively as possible, we planned the
publication of new international journal, Evidence-based Complementary and Alternative Medicine (eCAM). The journal
eCAM was published in 2004 and reached vol. 4th at present. In recent years, it has been proven that the neuroendocrinosystem adjusts the function of immune system and that there is a bidirectional regulation mechanism in these systems. We
examine the effect of hot spring hydrotherapy and walking exercise on number and function of the immunocompetent cells.
Hereafter, we aim at the establishment of an assessment of the alternative medicine throughout immunological parameters.

Publications
Originals
0200B001(K.Uchikawa), M.Sakuma, S.Matsuba, S.Shimizu, T.Motoyama, M.Kohno, N.Yamaguchi: Soybesn-peptide
modulates emotional hormones and leukocyte subsets in human peripheral blood, Medicine and biology., 153:477487, 2009 (in Japanese) .

－ 26 －

0210

Department of Medical Zoology

Name

Field of Specialization

IKEDA Teruaki

Immunological and biochemical studies of parasitic diseases

OIKAWA Yosaburo

diagnosis of parasitic disease，tick-borne disease

Faculty
Title

ICHIKAWA Hidetaka Immunological study for parasitic diseases

Keywords of Researchparasite, paragonimiasis, fascioliasis, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating
antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba,
metacercaria, excystment, atopic dermatitis, mite, Myobia musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Study on the invading mechanism of lung flukes into their final hosts.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Development of immunological and molecular biological diagnosis of parasitic diseases.

Publications
Originals
0210B001

Y.Oikawa, K.Tabara, T.Yoshida, T.Arai, M.Tokoro, N.Takada: Evaluation of some pathogens detected from theblood of field rodents in Japan, with special references to geographical distribution and infectivity of Babesia
microti, Ann. rep. Ohara Hosp., 49:7-14, 2009 (in Japanese) .

－ 27 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name
NOJIMA Takayuki
MINATO Hiroshi

Field of Specialization
surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001

Y.Masaki, L.Dong, A.Nakajima, H.Iwao, M.Miki, N.Kurose, E.Kinoshita, T.Nojima, T.Sawaki, T.Kawanami,
M.Tanaka, K.Shimoyama, C.Kim, M.Fukutoku, H.Kawabata, T.Fukushima, Y.Hirose, T.Takiguchi, S.Konda,
S.Sugai, H.Umehara: Intravascular large B cell lymphoma:proposed of the strategy for early diagnosis andtreatment of patients with rapid deteriorating condition, Int. J. Hematol., 89:600-610, 2009.

0220B002

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, Y.Shinomura, K.Imai, T.Saeki,
A.Azumi, S.Nakada, E.Sugiyama, S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano,
Y.Zen, M.Kaneko, K.Miyazaki, K.Tsubota, K.Eguchi, K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima,
S.Sugai, H.Umehara: Proposal for a new clinical entity,IgG4-positive multiorgan lymphoproliferative
syndrome:analysis of 64 cases of IgG4-related disorders, Ann. Rheum. Dis., 68:1310-1315, 2009.

0220B003

R.Terauchi, K.Sato, M.Takenaka, M.Yamashita, Y.Asakura, M.Nakano, N.Kurose, H.Minato, T.Nojima:
Intracytoplasmic lumina of urothelial carcinoma in urine cytology, J. Jpn. Soc. Clin. Cytol., 48:12-16, 2009 (inJapanese) .

Case Reports
0220D001(J.Shimizu), Y.Arano, N.Ishikawa, I.Adachi, T.Murata, C.Ikeda, T.Masunaga, H.Ohtake, H.Minato: Total
esophago-gastrectomy followed by composite reconstruction with retrosternal pedicled jejunum and antethoracicfree jejunal autograft: A case report, Ann Thorac Cardiovasc Surg, 15:31-37, 2009.

－ 28 －

0220D002

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, Y.Machida, T.Nojima, T.Terauchi, T.Sakuma: The multitude of cytologic
components in pulmonary pleomorphic carcinoma-A report of tow cases-, J. Jpn. Soc. Clin. Cytol., 48:220-225,
2009.

0220D003

H.Minato, T.Nojima, N.Kurose, E.Kinoshita: Adenomatoid tumor of the pleura, Pathol. Int., 59:567-571, 2009.

0220D004(M.Sasaki), I.Araki, T.Yasui, M.Kinosita, K.Itatsu, T.Nojima: Primary localized malignant biphasic mesothelioma of
the liver in a patient with asbestosis, World J. Gastroenterol., 15:615-621, 2009.

0220D005

T.Fukuyama, H.Kawahara, M.Yamada, N.Hayashi, H.Yano, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase,
T.Arisawa, K.Omote, T.Nojima: A case of IL-6 producing malignant mesothelioma of abdomen withthrombocytosis, jpn. j. gastroenterol., 109：546-553, 2009 (in Japanese) .

0220D006

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, Y.Masaki, E.Kinoshita, T.Sakuma:
Complete resection of an advanced mediastinal nonseminomatous germ cell tumor with multiple distant metastases
after Douwn-staging by chemotherapy, Ｔhe Japanese journal of thoracic surgery., 62:545-551, 2009 (inJapanese) .

0220D008

M.Yokoi, K.Hosokawa, H.Funaki, S.Yoshitani, S.Kinami, K.Omote, N.Ueda, Y.Nakano, T.Kosaka, H.Minato: Acase of retroperitioneal dedifferentiated liposarcoma successfully treated with IFM and CDDP, Cancer &chemotherapy., 36:2114-2116, 2009 (in Japanese) .

0220D010(J.Shimizu), Y.Arano, I.Adachi, N.Ishikawa, M.Morishita, W.Ikeda, B.Fuwa, S.Yokoｋawa, S.Minami, H.Minato:
Radical resection for superior sulcus tumor which is reqired resection of 1st rib through hook approach: report of acase, Medical journal of Mutual Aid Association., 58:278-283, 2009 (in Japanese) .

0220D011(J.Shimizu), W.Ikeda, Y.Arano, I.Adachi, M.Morishita, B.Fuwa, S.Yokokawa, S.Minami, S.Yamaguchi, N.Ishikawa,
G.Watanabe, H.Minato: Resection of advanced lung cancer invading the left atrium using cardiopulmonary bypass:report of a case, Medical journal of Mutual Aid Association., 58:272-277, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0220I001

Y.Masaki, N.Kurose, H.Iwao, A.Nakajima, M.Yamamoto, H.Takahashi, M.Kawano, T.Saeki, S.Matsui, A.Azumi,
S.Nishiyama, Y.Zen, T.Sumida, M.Kojima, T.Yoshino, S.Nakamura, N.Tomosugi, T.Takegami, S.Sugai, H.Umehara:
Clinico-pathological analysis of 107 cases of IgG4+MOLPS (IgG4-positive multi-organ lymphoprolife-rative
syndrome), 10th International symposium on Sjögren's syndrome, (BREST, '09.10).

－ 29 －

0230

Department of Social and Environmental Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases

ISHIZAKI Masao

Occupational Health, Job stress

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

NOBORISAKA Yuka

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(Y.Suwazono), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, M.Dochi, K.Nogawa: Biological half-life of
cadmium in the urine of inhabitants after cessation of cadmium exposure, Biomarkers., 14:77-81, 2009.

0230B002

K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki: Assessment of pinguecuｌa andpterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey
in Shanxi, China, Rehabilitation science : memoirs of the Tohoku Bunka Gakuen University Faculty of Medical
Science & Welfare, Department of rehabilitation., 5:31-40, 2009.

0230B003

K.Kitaoka-Higashiguti, Y.Morikawa, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Burnout andrisk factors for arteriosclerotic disease: follow-up study, J. Occup. Health, 51:123-131, 2009.

0230B004

M.Sakurai, K.Miura, T.Takamura, M.Ishizaki, Y.Morikawa, K.Nakamura, K.Yoshita, T.Kido, Y.Naruse, S.Kaneko,
H.Nakagawa: J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes:an 8year follow-up of velatively lean Japanese individuals., Diabet. Med., 26:753-759, 2009.

0230B005

K.Tawara, M.Nishijo, R.Honda, S.Maruzeni, T.Seto, T.Kido, S.Saito, H.Nakagawa: Effects of maternal dioxin
exposure on newborn size at birth among Japanese mother-infant pairs, Environ. Health Prevent. Med., 14:88-95,
2009.

0230B006(A.Inoune), N.Kawakami, A.Tsutsumi, A.Shimazu, M.Tsuchiya, M.Ishizaki, M.Tabata, M.Akiyama, A.Kitazume,
M.Kuroda, M.Kivimäki: Reliability and validity of the Japanese version of the Organizational Justice Questionnaire,
J. Occup. Health, 51:74-83, 2009.

0230B007(K.Tsuno), N.Kawakami, A.Inoue, M.Ishizaki, M.Tabata, M.Tsuchiya, M.Akiyama, A.Kitazume, M.Kuroda,
A.Shimazu: Intragroup and intergroup conflict at work, psychological distress, and work engagement in a sample ofemployees in Japan, Ind Health, 47:640-648, 2009.

－ 30 －

0230B008(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Estimation of benchmark rice cadmium doses as thresholdvalues for abnormal urinary findings with adjustment for consumption of Jinzu River water, Bull. Environ. Contam.
Toxicol., 83:102-107, 2009.

0230B009(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Influence of consumption of cadmium-polluted rice or
Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease, Biol Trace Elem Res,
127:257-268, 2009.

0230B010(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Association of lifetime cadmium intake or drinking Jinzu
River water with the occurrence of renal tubular dysfunction, Environ. Toxicol., 24:421-428, 2009.

0230B011(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido, H.Nakagawa: Influence of drinking and/or cooking with
Jinzu River water on the development of Itai-Itai disease, Biol Trace Elem Res, 129:46-57, 2009.

0230B012(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial follow-up study on renal
handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a generallinear mixed model, Biol Trace Elem Res, 129:261-269, 2009.

0230B013(A.Inoue), N.Kawakami, M.Ishizaki, M.Tabata, M.Tsuchiya, M.Akiyama, A.Kitazume, M.Kuroda, A.Shimazu: Three
job stress models/concepts and oxidative DNA damage in a sample of workers in Japan, J. Psychosom. Res.,
66:329-334, 2009.

0230B014(H.Suzuki), T.Kido, Y.Morikawa, H.Nakagawa, M.Ishizaki, Y.Naruse, M.Higashiyama, M.Dochi, Y.Suwazono,
K.Nogawa: The relationship between mental-health status and work-related factors in male Japanese overseas
employees, Journal of Tsuruma Health Society Kanazawa University, 33:21-33, 2009.

0230B015

M.Sakurai, K.Miura, K.Nakamura, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Relationship between
abdominal obesity, accumulation of metabolic abnormalities and risk of cardiovascular disease: An 11-year followup of middle-aged Japanese men, Japanese journal of cardiovascular disease prevention., 44:1-9, 2009 (inJapanese) .

Others0230F001(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Answer to the comments by Eric J. Grant et al. in "Radiation
unlikely to be responsible for high cancer rates among distal Hiroshima A-bomb survivors", Environ. HealthPrevent. Med., 14:250-253, 2009.

0230F002(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Hiroshima survivors exposed to very low doses of A-bomb primaryradiation showed a high risk for cancers, Environ. Health Prevent. Med., 14:209, 2009.

0230F003(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Answer to the comment by Yoshisada Shibata on "Hiroshima
survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers", Environ. HealthPrevent. Med., 14:157-158, 2009.

Presentations at Conference
International Conference (Presentations)
0230I001

M.Nakata, K.Kogi, I.Mori, Y.Yamada: The need for establishing an evidence-based statistics for occupational
accidents and diseases, 29th International Congress on Occupational Health, (Cape Town, '09.03)，234, 2009.

－ 31 －

0240

Department of Epidemiology and Public HealthFaculty
Title(Additional Post)(Additional Post)(Additional Post)

Name

Field of Specialization

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

NAKANISHI Yumiko

Preventive medicine

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(R.Oka), K.Miura, M.Sakurai, K.Nakamura, KYagi, S.Miyamoto, T.Moriuchi, H.Mabuchi, M.Yamagishi, Y.Takeda,
S.Hifumi, A.Inazu, A.Nohara, MA.Kawashiri, J.Kobayashi: Comparison of waist circumference with body mass index
for predicting abdominal adipose tissue, Diabetes Res. Clin. Pract., 83:100-105, 2009.

0240B002(K.Asayama), T.Ohkubo, S.Yoshida, K.Suzuki, H.Metoki, A.Harada, Y.Murakami, Y.Ohashi, H.Ueshima, Y.Imai,
H.Nakagawa, The Japan Arteriosclerosis Longitudinal Study(JALS) group: Stroke risk and antihypertensive drug
treatment in the general population:the Japan arteriosclerosis longitudinal study, J.Hypertens., 27:357-364, 2009.

0240B003

R.Naganuma, M.Sakurai, K.Miura, K.Yoshita, Y.Morikawa, T.Kido, H.Ueshima, H.Nakagawa, J.Stamler: Relation of
long-term body weight change to change in lipoprotein particle size in Japanese men and women:The INTRTMAP
Toyama study, Atherosclerosis, 206:282-286, 2009.

0240B004

K.Nakamura, F.Barzi, R.Huxley, TH.Lam, I.Suh, J.Woo, HC.Kim, VL.Feigin, D.Gu, M.Woodward, Asia pacificcohort studies collaboration: Does cigarette smoking exacerbate the effect of total cholesterol and high-density
lipoprotein cholesterol on the risk of cardiovascular diseases?, Heart, 95:909-916, 2009.

－ 32 －

0240B005(K.Miura), H.Nakagawa, Y.Ohashi, A.Harada, M.Takagi, T.Koshiro, A.Takahashi, M.Nishinaga, F.Soejima,
H.Ueshima, for the Japan arteriosclerosis longitudinal study (JALS) group: Four blood pressure indexes and therisk of stroke and myocardial infarction in Japanese men and women: a meta-analysis of 16 cohort studies,
Circulation, 119:1892-1898, 2009.

0240B006(Y.Suwazono), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, M.Dochi, K.Nogawa: Biological half-life of
cadmium in the urine of inhabitants after cessation of cadmium exposure, Biomarkers., 14:77-81, 2009.

0240B007

K.Kitaoka-Higashiguti, Y.Morikawa, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Burnout andrisk factors for arteriosclerotic disease: follow-up study, J. Occup. Health, 51:123-131, 2009.

0240B008

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H.Nakagawa: Middle-aged Japanese women are resistant to obesityrelated metabolic abnormalities, Metab. Clin. Exp., 58:456-459, 2009.

0240B009(M.Sasaki), K.Kitaoka, Y.Morikawa, H.Nakagawa: Relationship between stress coping and burnout in Japanesehospital nurses, J. Nurs. Manag., 17:359-365, 2009.

0240B010

M.Sakurai, K.Miura, T.Takamura, M.Ishizaki, Y.Morikawa, K.Nakamura, K.Yoshita, T.Kido, Y.Naruse, S.Kaneko,
H.Nakagawa: J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes:an 8year follow-up of velatively lean Japanese individuals., Diabet. Med., 26:753-759, 2009.

0240B011(DD.Nhu), T.Kido, R.Naganuma, N.Sawano, K.Tawara, M.Nishijo, H.Nakagawa, NN.Hung, LTH.Thom: A GIS studyof dioxin contamination in a Vietnamese region sprayed with herbicide, Environ. Health Prevent. Med., 14:353360, 2009.

0240B012(The emerging risk factors collaboration), ED.Angelantonio, N.Sarwar, P.Perry, S.Captoge, KK.Ray, A.Thompson,
AM.Wood, S.Lewington, N.Sattar, CJ.Packard, R.Collins, SG.Thompson, J.Danesh, H.Nakagawa: Major lipids,
apolipoproteins, and risk of vascular disease, JAMA, 302:1993-2000, 2009.

0240B013

H.Oda, M.Nishijo, H.Nakagawa, Y.Morikawa, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Urinary metallothioneinlevels and mortality in residents exposed to cadmium in the environment, J. Kanazawa. Med. Univ., 34:148-153,
2009.

0240B014

K.Tawara, M.Nishijo, R.Honda, S.Maruzeni, T.Seto, T.Kido, S.Saito, H.Nakagawa: Effects of maternal dioxin
exposure on newborn size at birth among Japanese mother-infant pairs, Environ. Health Prevent. Med., 14:88-95,
2009.

0240B015(T.Kido), K.Saito, R.Naganuma, C.Sakakibara, DD.Nhu, H.Suzuki, M.Nishijo, H.Nakagawa, K.Kusama, NN.Hung:
Association between dioxin concentrations in breast milk and dietary nutrient intake in Vietnam, Organohalogen
Compounds., 71:982-987, 2009.

0240B016(DD.Nhu), T.Kido, R.Naganuma, K.Saito, H.Suzuki, N.Kuroda, S.Honma, K.Honma, S.Maruzeni, M.Nishijo,
H.Nakagawa, NN.Hung, LTH.Thom: An epidemiological study on health effects by dioxin in Vietnam introductionof new "Hot Spot" area, Organohalogen Compounds., 71:890-895, 2009.

0240B017(AP.Kengne), K.Nakamura, F.Barzi, TH.Lam, R.Huxley, D.Gu, A.Patel, HC.Kim, M.Woodward, on behalf of the
Asia Pacigic Cohort Study Collaboration: Smoking, diabetes and cardiovascular diseases in men in the Asia-Pacificregion, J Diabetes., 1:173-181, 2009.

0240B018(The Asia Pacific Cohort Studies Collaboration), RR.Huxley, K.Nakamura, TH.Lam, F.Barzi, D.Batty,
S.Czernichow, H.Ueshima, HC.Kim, JW.Wong, X.Fang, V.Feigin, M.Woodward: Impact of cigarette smoking on
the relationship between body mass index and coronary heart disease: a pooled analysis of 3264 stroke and 2706
CHD events in 378579 individuals in the Asia Pacific region, BMC Public Health., 9:294, 2009.

0240B019(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido, H.Nakagawa: Influence of drinking and/or cooking with
Jinzu River water on the development of Itai-Itai disease, Biol Trace Elem Res, 129:46-57, 2009.

0240B020(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial follow-up study on renal
handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a generallinear mixed model, Biol Trace Elem Res, 129:261-269, 2009.

0240B021(DD.Nhu), T.Kido, R.Naganuma, K.Saito, H.Suzuki, N.Kuroda, S.Honma, PT.Tai, S.Maruzeni, M.Nishijo,
H.Nakagawa, NN.Hung, LTH.Thom: Hormone levels in the saliva of lactating Vietnamese mothers in a dioxin hotspot area, Journal of Tsuruma Health Society Kanazawa University, 33:59-66, 2009.

－ 33 －

0240B022(H.Suzuki), T.Kido, Y.Morikawa, H.Nakagawa, M.Ishizaki, Y.Naruse, M.Higashiyama, M.Dochi, Y.Suwazono,
K.Nogawa: The relationship between mental-health status and work-related factors in male Japanese overseas
employees, Journal of Tsuruma Health Society Kanazawa University, 33:21-33, 2009.

0240B023

Y.Hamazaki, K.Nakamura, K.Hirata, K.Teramoto, M.Matuda: What factors are associated with postnatal
depression in Japanese women?, Hokuriku Japanese Journal of Public Health., 35:58-62, 2009 (in Japanese) .

0240B024(K.Yoshita), M.Nakagawa, Y.Sugimori, K.Mira, M.Sakurai, T.Kami, Y.Arai, M.Nozue, R.Tomimatsu, H.Nakagawa,
H.Ishida: Effects of weight-reducing program conducted at work place with minimum burden of participants: A
program to prevent development of metabolic syndrome, mainly under the guidance of registered dieticians, Journalof the Japan Dietetic Association, 52:17-26, 2009 (in Japanese) .

0240B025

M.Sakurai, K.Miura, K.Nakamura, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Relationship between
abdominal obesity, accumulation of metabolic abnormalities and risk of cardiovascular disease: An 11-year followup of middle-aged Japanese men, Japanese journal of cardiovascular disease prevention., 44:1-9, 2009 (inJapanese) .

Reviews
0240C001(Emerging risk factors collaboation), S.Erpou, S.Kaptoge, PL.Perry, ED.Angeletonio, A.Thompson, IR.White,
SM.Marcovina, R.Collins, SG.Thompson, J.Danesh, H.Nakagawa, K.Miura: Lipoprotein(a) concentration and therisk of coronary heart disease, stroke, and nonvascular mortality, JAMA, 302:412-423, 2009.

0240C002

K.Nakamura, R.Huxley, A.Ansary-Moghaddam, M.Woodward: The hazards and benefits associated with smoking
and smoking cessation in Asia: a meta-analysis of prospective studies, Tob. Control., 18: 345-353, 2009.

Others
0240F001

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H. Nakagawa: Abnormal liver function tests and metabolic syndromeis fatty liver related to risks for atherosclerosis beyond obesity?, Intern. Med., 48:1573-1574, 2009.

0240F014

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0240H001

M.Sakurai, Prognostic factors of cardiomyopathy in Japan: Results from nationwide survey. China-Japan
Cardiovascular Forum 2009., The 73rd Annual Scientific Meeting of the Japan Circulation Society., (Osaka,'09.03).

－ 34 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

KITAMURA Osamu

Forensic Pathology，Drug Dependence

TAKEICHI Toshiaki

hemorheologe

WANG Lu

Tumor pathology, Endocrine pathology, Forensic pathology

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001

T.Takeichi, O.Kitamura: Detection of diatom in formalin-fixed tissue by proteinase K digestion, Forensic Sci. Int.,
190:19-23, 2009.

Others
0250F001

O.Kitamura: Detection of methamphetamine neurotoxicity in forensic autopsy cases, , Suppl 1:S63-65, 2009.

－ 35 －

0260

Department of Medical Education

Name

Field of Specialization

Faculty
Title

YASUDA Yukio
HORI Ariyuki
FUKUNAGA
Toshiharu
KURODA Naohiro

undergraduate clinical teaching, graduate education of physicians,
medical education
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
laboratory medicine, standardization of blood gas analysis, pulmonary
function test
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Originals
0260B001(T.Okuda), M.Matuoka, Y.Yoshida, T.Kanamori, T.Fukunaga: The blood gas control survey reference values inToyama Prefecture-Examination of the cause of dissociation from the data-, Japanese Journal of Medical
Technology, 58:306-310, 2009 (in Japanese) .

－ 36 －

Clinical Medicine

0300

Department of Cardiovascular Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

MATSUI Shinobu

Heart failure

ASAJI Takayoshi

Heart failure

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention
KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

UENISHI Hiroaki

Ischemic heart disease, Coronary intervention

AKAO Hironobu

Ischemic heart disease, Coronary intervention

TAKEDA Kenji

Molecular Biology

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

KASENO Kenichi

Arrhythmia, Catheter ablation

MOTOYAMA Atsushi Ischemic heart disease，Coronary intervention
IWADARE Mizuho

Atherosclerosis, hypertension

WAKASA Minoru

Heart failure

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001(T.Nakajima), R.Takagi, Y.Tajima, C.Makita, Y.Kominato, J.Kuribara, S.Ohshima, H.Tada, H.Tsurugaya,
Y.Kobayashi, H.Takeshita, Y.Kawai, T.Yasuda: Development of a sensitive enzyme-linked immunosorbent assay
for measurement of Dnase Ⅰin human serum, Clin. Chim. Acta, 403:219-222, 2009.

0300B002(T.Yasuda), R.Iida, Y.Kawai, T.Nakajima, Y.Kominato, J.Fujihara, H.Takeshita: Serum deoxyribonuclease I can beused as a useful marker for diagnosis of death due to ischemic heart disease, Leg Med (Tokyo)., 11:S213-S215,
2009.

－ 37 －

0300B003(J.Kuribara), H.Tada, Y.Kawai, R.Kawaguchi, H.Hoshizaki, K.Arakawa, M.Kitayama, K.Kajinami, M.Kurabayashi,
S.Oshima, K.Taniguchi, Y.Kominato, T.Yasuda: Levels of serum deoxyribonuclease Ⅰactivity on admission inpatients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling,
J Cardiol, 53:196-203, 2009.

Case Reports
0300D001

R.Saito, H.Akao, K.Kaseno, Y.Nomura, M.Kitayama, H.Tsugawa, K.Kajinami: Marked PT-INR prolongation
associated with appetite loss due to urinary tract infection in a late elderly case with chronic atrial fibrillation, Jpn.
j. geriat., 46:541-544, 2009 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0300G001

K.Kajinami, R.Sato, H.Akao, E.Schaefer: Statin pharmacogenomics:Role of combined analysis of functionallyrelated loci, XV International Symposium on Atherosclerosis 2009, (Boston, '09.06).

International Conference (Presentations)
0300I001

R.Sato, K.Kajinami, H.Akao, A.Motoyama: Low bone mineral density - A risk of coronary and carotid
atherosclerosis in postmenopausal women, XV International Symposium on Atherosclerosis 2009, (Boston, '09.06).

0300I002

H.Akao, M.Kitayama, Y.Kawai, K.Kajinami: The role of Tenascin-C in advanced coronary atherosclerosis, XVInternational Symposium on Atherosclerosis 2009, (Boston, '09.06).

0300I003

H.Akao, M.Kitayama, Y.Kawai, R.Sato, A.Motoyama, M.Wakasa, H.Aoki, R.Saito, K.Fujibayashi, K.Kajinami:
Potential role of fetuin-A in advanced coronary atherosclerosis : coronary rotational atherectomy study, ESC
Congress 2009, (Barcelona, '09.08).

－ 38 －

0310

Department of Respirology (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

TOGA Hirohisa

lung physiology, sleep disordered breathing

OSANAI Kazuhiro

lung cell and molecular biology , COPD

HUANG Jyongsu

lung physiology, sleep disordered breathing

IGUCHI Masaharu

clinical respiratory medicine

TAKAHASHI
Masakatsu

clinical respiratory medicine , pulmonary tuberculosis

TOBE Takeyasu

clinical respiratory medicine

TSUCHIHARA
Katsumaclinical respiratory medicine

OIKAWA Taku

clinical respiratory medicine , lung cancer

NAKAGAWA Kenclinical respiratory medicine , lung cancer

FUJIMOTO Yuki

clinical respiratory medicine

KOJIMA Koji

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, NO, matrix metalloproteinase, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic
reflection technique, upper airway compliance, CPAP, BiPAP, lung cancer, apoptosis, Fas, Fas ligand

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Apoptosis of lung cancer cells

Publications
Originals
0310B001

H.Takano, T.Shibamoto, W.Zhang, Y.Kurata, H.Toga: Hepatic microvascular pressure during anaphylactic shockin anesthetized rats, Microvasc. Res., 78:169-173, 2009.

0310B004

M.Saito: Upper airway function assessed with negative expiratory pressure technique during wakefulness in patientswith obstructive sleep apnea, J. Kanazawa. Med. Univ., 34:59-67, 2009 (in Japanese) .

0310B005

M.Kobayashi: Change of alveolar type Ⅱ cells affected by mutation of Rab38 small GTPase gene, J. Kanazawa.
Med. Univ., 34:133-141, 2009 (in Japanese) .

Case Reports
0310D001

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, Y.Masaki, E.Kinoshita, T.Sakuma:
Complete resection of an advanced mediastinal nonseminomatous germ cell tumor with multiple distant metastases
after Douwn-staging by chemotherapy, Ｔhe Japanese journal of thoracic surgery., 62:545-551, 2009 (inJapanese) .

－ 39 －

Presentations at Conference
International Conference (Presentations)
0310I001

K.Osanai: Abnormal lung phenotype in Rab38-deficient rats, rodent models of Hermansky-Pudlak syndrome,
FASEB 2009 Meetings, (New Orleans, '09.04).

－ 40 －

0320

Department of Gastroenterology

Name

Field of Specialization

ARISAWA Tomiyasu

Gastro-intestinal disorders

Faculty
Title(Additional Post)

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

YANO Hirokazu

Clinico-epidemiology of alcoholic liver injury

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer
FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

OOTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

YAMADA Masayoshi

Nonalcoholic steatohepatitis and oxidative stress

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease

SAITO Takashi

Treatment for metabolic syndrome

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis－ 41 －

Publications
Originals
0320B001(T.Tahara), T.Arisawa, T.Shibata, H.Yamashita, D.Yoshioka, I.Hirata: Effect of promoter methylation of multidrug
resistance 1(MDR1)gene in gastric carcinogenesis, Anticancer Res., 29:337-342, 2009.

0320B002(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
H.Fujita, Y.Nakagawa, M.Nagasaka, M.lwata, K.Takahama, M.Waatanabe, H.Nakano, I.Hirata, T.Arisawa:
Promoter methylation of protease-activated receptor (PAR2)is associated with severe clinical phenotypes ofulcerative colitis (UC), Clin. Exp. Med., 9:125-130, 2009.

0320B003(T.Tahara), T.Arisawa, T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano,
Y.Kamiya, H.Fujita, M.Nagasawa, M.Iwata, K.Takahama, M.Watanabe, H.Nakano, I.Hirata: Effect ofpolymorphisms in the 3'-untranslated region(3'-UTR)of VEGF gene on gastric pre-malignant condition, Anticancer
Res., 29:485-490, 2009.

0320B004(T.Tahara), T.Shibata, M.Nakamur, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Komiya, H.Fujita,
M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, H.Yamashita, H.Nakano, I.Hirata, T.Arisawa: COMT gene
Val158Met polymorphism influences the severity of interstinal metaplasia in H.Pylori infected older subjects,
Hepatogastroenterology, 56:411-415, 2009.

0320B005(T.Tahara), T.Shibata, M.Nakamura, D.Yoshioka, M.Okubo, T.Arisawa, I.Hirata: Gastric mucosal pattern by using
magnifying narrolv-band imaging endoscopy clearly distinguishes histological and serological severity of chronic
gastritis, Gastroenterological Endoscopy, 70:246-253, 2009.

0320B006(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
Y.Nakagawa, H.Fujita, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, I.HirataI, T.Arisawa: Effect of MDR1
gene promoter methylation in patients with ulcerative colitis, Int. J. Mol. Med., 23:521-527, 2009.

0320B007(T.Tahara), T.Shibata, I.Hirata, H.Nakano, T.Arisawa: CD14 promoter-159 polymorphism is associated with
reduced risk of intestinal-type gastric cancer in a Japanese population, Dig. Dis. Sci., 54:1508-1512, 2009.

0320B008(T.Tahara), T.Shibata, H.Yamashita, M.Nakamura, D.Yoshioka, M.Okubo, I.Hirata, T.Arisawa: Chronic
nonsteroidal anti-inflammatory drug(NSAID)use suppresses multiple CpG islands hyper methylation(CIHM) of
tumor suppressor genes in the human gastric mucosa, Cancer Sci., 100:1192-1197, 2009.

0320B009(T.Shibata), T.Tahara, I.Hirata, T.Arisawa: Genetic polymorphism of interleukin-17A and-17F genes in gastriccarcinogenesis, Hum. Immunol., 70:547-551, 2009.

0320B010(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, I.Hirata, T.Arisawa: Effect of polymorphisms in the
3' untranslated region (3'-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer
diseases in Japan, Mol. Carcinog., 48:1030-1037, 2009.

0320B011(T.Tahara), T.Arisawa, T.Shibata, H.Yamashita, I.Hirata: Association between cyclin DI (CCND1) polymorphismand gastric cancer risk in Japanese population, Hepatogastroenterology, 56:1232-1235, 2009.

0320B012(T.Tahara), T.Arisawa, T.Shibata, M.Nakamura, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
H.Fujita, Y.Nakagawa, M.Nagasaka, M.lwata, K.Takahama, M.Watanabe, H.Yamashita, I.Hirata: Increased numberof methylated CpG islands correlates with Helicobacter pylori infection, histological and serological severity ofchronic gastritis, Eur. J. Gastroenterol. Hepatol., 21:613-619, 2009.

0320B013(T.Tahara), T.Shibata, FY.Wang, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, Y.Kamiya,
M.Nakamura, H.Fujita, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, H.Nakano, I.Hirata, T.Arisawa: Mannanbinding lectin B allele is associated with a risk of developing more severe gastric mucosal atrophy in Helicobacter
pylori-infected Japanese patients, Eur. J. Gastroenterol. Hepatol., 21:781-786, 2009.

0320B014(T.Tahara), T.Shibata, T.Arisawa, M.Nakamura, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
H.Fujita, M.Nagasaka, M.Iwata, H.Yamashita, H.Nakano, I.Hirata: The BB genotype of heat-shock protein(HSP)70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients, Anticancer
Res., 29:3453-3458, 2009.

－ 42 －

0320B015(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, I.Hirata, T.Arisawa: MTHFR 677T
carrier inｆｌuences the methylation status of H. pylori-infected gastric mucosa in older subjects, Dig. Dis. Sci.,
54:2391-2398, 2009.

0320B016(T.Tahara), T.Shibata, H.Yamashita, I.Hirata, T.Arisawa: The role of RANTES promoter polymorphism infunctional dyspepsia, J. Clin. Biochem. Nutr., 45:235-240, 2009.

0320B017(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, I.Hirata, T.Arisawa: RANTES promoter genotype
and gastric cancer risk in a Japanese population, Anticancer Res., 29:4265-4269, 2009.

0320B018(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda, N.Maruyama,
T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, Iwata M, I.Hirata, T.Arisawa: Effect of polymorphismsof IL-17A,-17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa, Int. J. Mol.
Med., 24:563-569, 2009.

0320B019(T.Tahara), T.Shibata, F.Wang, M.Nakamura, M.Sakata, H.Nakano, I.Hirata, T.Arisawa: A genetic variant of the
p22PHOX component of NADPH oxidase C242T is associated with reduced risk of functional dyspepsia in
Helicobacter pylori-infected Japanese individuals, Eur. J. Gastroenterol. Hepatol., 21:1363-1368, 2009.

0320B020

ZS.Zhao, T.Shibamoto, M.Tsutsumi, S.Cui, WM.Zhang, H.Takano, Y.Kurata: Mouse hepatic portal
venoconstrictive response to vasoconstrictors is much weaker than that in rat, J. Cardiovasc. Pharmacol., 54:421426, 2009.

Case Reports
0320D001

M.Yamada, H.Shiroeda, S.Shiroeda, K.Sato, T.Arisawa, M.Tsutsumi: Cholangiocarcinoma producig parathyroid
hoemone-related peptide treated with chemoradiation usig gemcitabine and S-1, Intern. Med., 48:2097-2100,
2009.

0320D002

T.Fukuyama, H.Kawahara, M.Yamada, N.Hayashi, H.Yano, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase,
T.Arisawa, K.Omote, T.Nojima: A case of IL-6 producing malignant mesothelioma of abdomen withthrombocytosis, jpn. j. gastroenterol., 109：546-553, 2009 (in Japanese) .

Short Communications
0320E001(M.Nakamura), T.Tahara, T.Shibata, D.Yoshioka, M.Okubo, K.Takahama, M.Watanabe, T.Arisawa, I.Hirata.:
Diagnostic efficacy of autoｆｌuorescence and reflectance imaging endoscopy for lateral extension of early gastriccancers, Gastroenterological Endoscopy, 70:599, 2009.

Presentations at Conference
International Conference (Presentations)
0320I001(M.Okubo), T.Tahara, T.Shibata, M.Nakamura, D.Yoshioka, N.Maruyama, T.Kamano, Y.Kamiya, H.Fujita,
Y.Nakagawa, M.Nagasaka, M.lwata, K.Takahama, M.Watanabe, T.Arisawa, I.Hirata: Classification of gastricmucosal pattems in the uninvolved gastric antrum by using magnitying NBI，in relation to H.pylori infection,
histological and serological severity of chronic gastritis, DDW 2009, (Chicago, '09.06).

0320I002(T.Tahara), T.Shibata, M.Nakamura, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya, H.Fujita,
Y.Nakagawa, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, T.Arisawa, l.Hirata: Gastric mucosal pattrn using
magnifying NBI endoscopy clearly distinguishes histological,and serological severity of chronic gastritis andpredicts gastric cancer occurrence, DDW 2009, (Chicago, '09.06).

0320I003(T.Shibata), T.Tahara, T.Arisawa, I.Hirata: IL-6r -183a carrier is associated with ditfuse type of gastric cancer inJapanese, DDW 2009, (Chicago, '09.06).

－ 43 －

0320I004(T.Tahara), T.Shibata, M.Okubo, D.Yoshioka, M.Nakamura, Y.Nakagawa, l.Hirata, T.Arisawa: Chronic
nonsteroidal anti-innammatory drugs (NSAIDs) use suppresses DNA methylation in human gastric mucosa, DDW
2009, (Chicago, '09.06).

0320I005(T.Tahara), T.Shibata, I.Ｈirata, T.Arisawa: Efkct of promoter methylation of multidrug resistance 1(MDR1) gene ingastric carcinogenesis, DDW 2009, (Chicago, '09.06).

0320I006

M.Yamada, H.Shiroeda, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Analysis of C-kit and pdgfrα genemutation in gastrointestinal stromal tumor of the small intestine, DDW 2009, (Chicago, '09.06).

0320I007(M.Okubo), T.Tahara, T.Shibata, M.Nakamura, D.Yoshioka, N.Maruyama, T.Kamano, Y.Kamiya, H.Fujita,
Y.Nakagawa, M.Nagasaka, M.lwata, K.Takahama, M.Watanabe, T.Arisawa, I.Hirata: Classification of gastricmucosal patterns in the uninvolved gastric antrum by using magnifying NBI，in relation to H.pylori infection,
histological and serological severity of chronic gastritis, DDW 2009, (Chicago, '09.06).

0320I008(T.Tahara), T.Shibata, M.Nakamura, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya, H.Fujita,
Y.Nakagawa, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, T.Arisawa, l.Hirata: Gastric mucosal pattrn using
magnifying NBI endoscopy clearly distinguishes histological,and serological severity of chronic gastritis andpredicts gastric cancer occurrence, DDW 2009, (Chicago, '09.06).

0320I009(J.George), M.Tsutsumi, J.D'Armiento: MMP-13 deletion protects monocrotaline induced liver injury in mice, The
Liver Meeting 2009, (Boston, '09.10).

0320I010(T.Tahara), T.Shibata, M.Nakamura, I.Hirata, T.Arisawa: Association between polymorphisms in the
3’untranslated region(3’-UTR)of vascular endothelial growth factor(VEGF)gene and gastric cancer incidence inJapanese population., UEGW2009, (London, '09.11).

0320I011(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, Yonemura, Y.Maeda, D.Yoshioka, H.Yamashita, I.Hirata,
T.Arisawa: Chronic nonsteroidal anti-inflammatory draug(NSAID)use sppresses multiple cpg islands hyper
methylation(CIHM)of tumor suppressorgenes in the humangastric, UEGW2009, (London, '09.11).

0320I012(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, J.Yonemura, Y.Maeda, D.Yoshioka, N.Maruyama, Kamano,
Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, T.Arisawa, I.Hirata: Gastric mucosal pattern using
magnifying nbiendoscopy clearly H.Pylori induced chronic gastritis and predicts gastric cancer occurrence,
UEGW2009, (London, '09.11).

0320I013(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, D.Yoshioka, I.Hirata, T.Arisawa: Homozygous trpv1 315c
influences the susceptibility to functional dyspepsia(FD), UEGW2009, (London, '09.11).

0320I014(M.Nakamura), T Arisawa, T.Shibata, T.Tahara, M.Okubo, I.Hirata: Prospective randomized controlled trial of
proton-pump inhibitor versus rebamipidl-based proton-pumo inhibitor therapy for treatment 017 endoscopic
submucosal dissection-related complication, UEGW2009, (London, '09.11).

－ 44 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

ASAKA Mitsuhiro

Cellular immunity in uremia, Clinicopathological study of primary
nonfunction and chronic allograft nephropathy in renal transplantation

YAMAYA Hideki

Clinical nephrology,

OKUYAMA Hiroshi

Clinical nephrology,

ADACHI Hiroki

Clinical nephrology,

CHIKAZAWA
Yoshihiro

Clinical nephrology,

NAKAGAWA Masaru Clinical nephrology,
HAYAMA Satoshi

Clinical nephrology,

ATSUMI Hirokatsu

Clinical nephrology

IMURA Junko

Clinical nephrology

FUJIMOTO Keiji

Clinical nephrology

KIMURA Shogo

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

Publications
Originals
0330B001(S.Matsuo), E.Imai, M.Horio, Y.Yasuda, K.Tomita, K.Nitta, K.Yamagata, Y.Tomino, H.Yokoyama, A.Hishida:
Revised equations for estimated GFR from serum creatinine in Japan, Am. J. Kidney Dis., 53:982-992, 2009.

－ 45 －

0330B002(E.Imai), M.Horio, T.Watanabe, K.Iseki, K.Yamagata, S.Hara, N.Ura, Y.Kiyohara, T.Moriyama, Y.Ando,
S.Fujimoto, T.Konta, H.Yokoyama, H.Makino, A.Hishida, S.Matsuo: Prevalence of chronic kidney disease in theJapanese general poulation, Clin Exp Nephrol, 13:621-630, 2009.

0330B003

H.Okuyama, S.Kimura, H.Atsumi, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Imamura, H.Yamaya,
M.Asaka, N.Tomosugi, H.Yokoyama: The relationship between initial diagnosis and long-term prognosis in lupus
nephritis, Jpn. J. Nephrol., 51：44-50, 2009 (in Japanese) .

0330B004(K.Sato), M.Asaka, M.Nakagawa, H.Imamura, H.Yokoyama, I.Ishikawa: Prophylactic continuous hemodialysis after
coronary angiography in patients wit renal insufficiency, The Journal of Japanese Association of Dialysis
Physicians., 42：237-243, 2009 (in Japanese) .

Others
0330F006

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0330I001

H.Yokoyama: J-RBR(Japan Renal Biopsy Registry) and J-KDR(Japan Kidney Disease Registry)-Data base forclinicopathological studies constructed by Japanese Society of Nephrology-, The 3rd Research Forum on Chronic
Kidney Disease, (Nagoya, '09.02).

0330I002

Y.Masaki, N.Kurose, H.Iwao, A.Nakajima, M.Yamamoto, H.Takahashi, M.Kawano, T.Saeki, S.Matsui, A.Azumi,
S.Nishiyama, Y.Zen, T.Sumida, M.Kojima, T.Yoshino, S.Nakamura, N.Tomosugi, T.Takegami, S.Sugai, H.Umehara:
Clinico-pathological analysis of 107 cases of IgG4+MOLPS (IgG4-positive multi-organ lymphoprolife-rative
syndrome), 10th International symposium on Sjögren's syndrome, (BREST, '09.10).

0330I003

H.Yokoyama, A.Saito, Y.Saito, I.Ishikawa: Intact parathyroid hormone levels at 3 hours of loading test reflect theeffects of Cinacalcet in both hemodialysis and renal transplanted patients., Renal Week 2009 ASN`s 42nd Annual
Meeting ＆ Scientific Exposition, (SanDiego, '09.10).

0330I004(S.Kitajima), H.Yamauchi, A.Hara, K.Kitagawa, N.Sakai, K.Furuichi, H.Yokoyama, S.Kaneko, T.Wada:
Clinicopathological manifestation in patients of idiopathic membranous nephropathy with relapse, Renal Week 2009ASN`s 42nd Annual Meeting ＆ Scientific Exposition, (SanDiego, '09.10).

－ 46 －

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

KOYA Daisuke

diabetes, hypertension, obesity, aging

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterone secretion

NAKAGAWA Atsushi pancreatic and gut hormones, pituitary diseases
KONISHI Kazunori

diabetes, arteriosclerosis

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

IMAIZUMI Noriko

intracellular mechanisms of aldosterone synthesis, diabetes

FURUYA Keisuke

diabetes, thyroid diseases

KITADA Munehiro

diabetes, hypertension

ITO Hiroki

diabetes

FUJII Mizue

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001(N.Deji), S.Kume, S.Araki, M.Soumura, T.Sugimoto, K.Isshiki, M.Chin-Kanasaki, M.Sakaguchi, D.Koya,
M.Haneda, A.Kashiwagi, T.Uzu: Structural and functional changes in the kidneys of high-fat diet-induced obese
mice, Am. J. Physiol. Renal Physiol., 296:F118-F126, 2009.

－ 47 －

0340B002

K.Konishi, S.Nakano, H.Seto, S.Tsuda, D.Koya: Carotid atherosclerosis mediated by visceral adiposity andadipocytokines in type 2 diabetic subjects, Diabetes Res. Clin. Pract., 85:171-178, 2009.

0340B003

D.Koya, M.Haneda, S.Inomata, Y.Suzuki, D.Suzuki, H.Makino, K.Shikata, Y.Murakami, Y.Tomino, K.Yamada,
S.I.Araki, A.Kashiwagi, R.Kikkawa: Long-term effect of modification of dietary protein intake on the progerssion ofdiabetic nephropathy: a randomised controlled trial, Diabetologia, 52:2037-2045, 2009.

0340B004(S.Araki), H.Matsuno, M.Haneda, D.Koya, Y.Kanno, J.Itho, A.Kishi, K.Isshiki, T.Sugimoto, H.Maegawa,A.Kashiwagi, T.Uzu: Correlation between albuminuria and spontaneous platelet microaggregate formation in type 2
diabetic patients, Diabetes Care., 32:2062-2067, 2009.

Reviews
0340C001

F.Liang, S.Kume, D.Koya: SIRT1 and insulin resistance, Nat Rev Endocrinol., 5:367-373, 2009.

0340C002

L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto: Silent
information regulator, sirtuin 1, and age-related diseases, Nat. Clin. Pract. Rheumatol., 9:7-15, 2009.

Presentations at Conference
International Conference (Presentations)
0340I001(Y.Tanaka), S.Kume, S.Araki, K.Isshiki, T.Sugimoto, D.Koya, M.Haneda, T.Uzu: Effects of PPARα agonist
fenofibrate on renal injury induced by a hgh-fat diet, American Diabetes Association 69th Scientific Sessions, (New
Orleans, LA, USA, '09.06)，Diabetes (Abstract Book 69th Scientific Sessions), 58(Suppl.1):A213, 2009.

0340I002

S.Tsuda, S.Nakano, D.Koya: Combination therapy of ezetimibe and statin rather than ezetimibe monotherapy
reduces urinary albumin excretion rate in moderate-to-high risk subjects, American Diabetes Association 69th
Scientific Sessions, (New Orleans, LA, USA, '09.06)，"New Orleans, LA, USA", 58(Suppl.1):A243, 2009.

0340I003

D.Koya, S.Kume, A.Kashiwagi: Effect of SIRT3 overexpression in endothelial cells in vivo on HFD-induced
metabolic derangements, American Diabetes Association 69th Scientific Sessions, (New Orleans, LA, '09.06)，
Diabetes (Abstract Book 69th Scientific Sessions), 58(Suppl.1):A398, 2009.

0340I004

H.Atsumi: Combination therapy of ezetimibe and statin rather than ezetimibe monotherapy reduces urinary albumin
excretion rate in moderate-to-high risk subjects, The 15th Korea-Japan Symposium on Diabetes Mellitus, (Jeju
Island, Korea, '09.09).

0340I005

O.Tachibana, Y.Sasagawa, K.Torigoe, K.Yamamoto, S.Siraga, K.Okamoto, T.Iida, T.Akai, H.Iizuka, A.Nakagawa,D.Koya: Expression of interleukin-1beta,interleukin-6, interleukin-12 and TNF alpha in human rathke cleft cysts A possible inducer of secondary hypophysitisassosiated with rathke cleft cyst-, The 11th International Pitutiary
Pathology Society(IPPS)Meeting, (Tokushima, '09.10).

－ 48 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

UMEHARA Hisanori

Hematology and Immunology

HIROSE Yuko

Hematology and Immunology,Transfusion Medicine

FUKUSHIMA
Toshihiro

Hematology and Immunology,Clinical Parmacology

MASAKI Yasufumi

Hematology and Immunology,Transfusion Medicine

TANAKA Masao

Rheumatology,Immunology

FUJITA Yoshimasa

Rheumatology,Immunology

SAWAKI Toshioki

Hematology and Immunology

KAWANAMI Takafumi Hematology and Immunology
JIN Zhexiong

Immunology

SAKAI Tomoyuki

Hematology and Immunology

MIKI Miyuki

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A) Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1) Effects of chemokines on
vascular injury and Th1 response during chronic inflammation. 2) Function of microdomain (lipid rafts) on lymphocyte
activation and its contribution in autoimmune diseases. 3) Analysis of immunological disorder in sphingomyelin knockout
mice. 4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5) Detection of stem cells insalivary glands and its implication for regenerative medicine.
B) Studies of hematological malignancies and development of anti-cancer drugs. 1) Analysis of EB-virus proteins and theirroles in lymphoproliferative disorders. 2) Molecular biological analysis of drug resistance. 3) Roles of sphingomyelin on
apoptosis.

Publications
Originals
0350B001

Y.Masaki, L.Dong, A.Nakajima, H.Iwao, M.Miki, N.Kurose, E.Kinoshita, T.Nojima, T.Sawaki, T.Kawanami,
M.Tanaka, K.Shimoyama, C.Kim, M.Fukutoku, H.Kawabata, T.Fukushima, Y.Hirose, T.Takiguchi, S.Konda,
S.Sugai, H.Umehara: Intravascular large B cell lymphoma:proposed of the strategy for early diagnosis andtreatment of patients with rapid deteriorating condition, Int. J. Hematol., 89:600-610, 2009.

－ 49 －

0350B002

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, Y.Shinomura, K.Imai, T.Saeki,
A.Azumi, S.Nakada, E.Sugiyama, S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano,
Y.Zen, M.Kaneko, K.Miyazaki, K.Tsubota, K.Eguchi, K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima,
S.Sugai, H.Umehara: Proposal for a new clinical entity,IgG4-positive multiorgan lymphoproliferative
syndrome:analysis of 64 cases of IgG4-related disorders, Ann. Rheum. Dis., 68:1310-1315, 2009.

0350B003

S.Sugai, H.Takahashi, S.Ohta, M.Nishiyama, M.Takei, S.Sawada, K.Yamaji, H.Oka, H.Umehara, I.Koni,
E.Sugiyama, S.Nishiyama, A.Kawakami: Efficacy and safety of rebamipide for the treatment of dry mouth symptoms
in patients with Sjögren's syndrome:a double-blind placebo-controlled multicenter trial, Mod Rheumatol, 19:114124, 2009.

0350B004(T.Fujii), M.Okada, Y.Fujita, T.Sato, M.Tanaka, T.Usui, H.Umehara, T.Mimori: Vaccination with autoreactive
CD4+ Th1 clones in lupus-prone MRL/Mp-Fas lpr/lpr mice, J. Autoimmun., 33:125-134, 2009.

0350B005

T.Sakai: Mechanisms of bortezomib-induced apoptosis in T cell lines, J. Kanazawa. Med. Univ., 34:125-132, 2009
(in Japanese) .

0350B006

XP.Tong: Prevalence and relevance to disease manifestation of autoantibodies to RBP1-like protein(Rbik) inrheumatoid arthritis, J. Kanazawa. Med. Univ., 34:142-147, 2009 (in Japanese) .

Reviews
0350C001(T.Daniels), L.Criswell, C.Shiboski, S.Shiboski, H.Lanfranchi, Y.Dong, M.Schiodt, H.Umehara, S.Sugai,
S.Challacombe, J.Greenspan: An early view of the international Sjögren's syndrome registry, Arthritis Rheum.,
61:711-714, 2009.

0350C002

H.Umehara, T.Sawaki, T.Kawanami, Y.Masaki, T.Fukushima: Sjögren's syndrome, Nipponrinsho., 67:511-516,
2009 (in Japanese) .

Case Reports
0350D001

T.Fukushima, H.Iwao, A.Nakazima, M.Miki, T.Sakai, T.Sawaki, M.Tanaka, Y.Masaki, Y.Hirose, H.Umehara:
MRSA-pyomyositis in a patient with acute myelogenous leukemia after intensive chemotherapy, Anticancer Res.,
29:3361-3364, 2009.

0350D002

A.Sakai, Y.Shimode, H.Tsuji, Y.Masaki: Huge malignant lymphoma of the thyroid gland complicated by recurrent
esophageal and tracheal fistulas induced by chemotherapy, J. Kanazawa. Med. Univ., 34:72-76, 2009.

0350D003

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, Y.Masaki, E.Kinoshita, T.Sakuma:
Complete resection of an advanced mediastinal nonseminomatous germ cell tumor with multiple distant metastases
after Douwn-staging by chemotherapy, Ｔhe Japanese journal of thoracic surgery., 62:545-551, 2009 (inJapanese) .

0350D004

T.Fukushima, H.Iwao, A.Nakashima, M.Miki, T.Sakai, T.Sawaki, M.Tanaka, Y.Masaki, Y.Hirose, H.Umehara: Very
Good Partial Response and Long Time to Progression by Short-Term Bortezomib Plus Dexamethasone Therapy fora Patient with Relapsed and Refractory Multiple Myeloma―A Case Report, Cancer & chemotherapy., 36:13871389, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0350I001

Y.Masaki, N.Kurose, H.Iwao, A.Nakajima, M.Yamamoto, H.Takahashi, M.Kawano, T.Saeki, S.Matsui, A.Azumi,
S.Nishiyama, Y.Zen, T.Sumida, M.Kojima, T.Yoshino, S.Nakamura, N.Tomosugi, T.Takegami, S.Sugai, H.Umehara:
Clinico-pathological analysis of 107 cases of IgG4+MOLPS (IgG4-positive multi-organ lymphoprolife-rative
syndrome), 10th International symposium on Sjögren's syndrome, (BREST, '09.10).

－ 50 －

0350I002

T.Kawanami, Y.Matsuzaki, T.Sawaki, T.Sakai, H.Iwal, A.Nakajima, M.Miki, Z-X.Jin., Y.Fujita, M.Tanaka,
Y.Masaki, T.Fukushima, H.Umehara: Identification of human salivary stem cells from cultured labial minor salivary
cells, 10th International symposium on Sjögren's syndrome, (Brest, '09.10).

0350I003

T.Sawaki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, Y.Fujita, T.Fukushima, H.Umehara: Sjögren's
syndrome and risk of non-Hodgkin lymphoma, mono-center analysis in japan, 10th International symposium
Sjögren's syndrome, (Brest, '09.10).

－ 51 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

MATSUI Makoto

Clinical neurology,Neuroimmunology,Clinical Immunology

TANAKA Keiko

Clinical neurology,Neuroimmunology

NAGAYAMA Shigeni

Clinical neurology,Neuroimmunology

KAWAMURA
Kazuyuki

Clinical neurology,Neuroimmunology

NAKANISHI Megumi

Clinical neurology,Neuroimmunology

KAITO Muichi

Clinical neurology

GONDO Yuichiro

Clinical neurology

INADA Hiroyuki

Applied Zoology

NAKATA Michiyo

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(S.Kamei), S.Kuzuhara, M.Ishihara, A.Morita, N.Taira, M.Togo, M.Matsui, M.Ogawa, K.Hisanaga, T.Mizutani,
S.Kuno: Nationwide survey of acute juvenile female non-herpetic encephalitis in japan:Relationship to anti-Nmethyl-d-aspartate receptor encephalitis, Intern. Med., 48:673-679, 2009.

0360B002(T.Ishizu), J.Kira, M.Osoegawa, T.Fukazawa, S.Kikuchi, K.Fujihara, M.Matsui, T.Kohriyama, G.Sobue,
T.Yamamura, Y.Itoyama, T.Saida, K.Sakata: Heterogeneity and continuum of multiple sclerosis phenotypes injapanese according to the results of the fourth nationwide survey, J. Neurol. Sci., 280:22-28, 2009.

0360B003(M.Osoegawa), J.Kira, T.Fukazawa, K.Fujihara, S.Kikuchi, M.Matsui, T.Kohriyama, G.Sobue, T.Yamamura,
Y.Itoyama, T.Saida, K.Sakata, H.Ochi, T.Matsuoka: Temporal changes and geographical differences in multiple
sclerosis phenotypes in japanese:nationwide survey results over 30 years, Mult.Scler, 15:159-173, 2009.

0360B004(M.Kinoshita), Y.Nakatsuji, M.Moriya, T.Okuno, A.Kumanogoh, M.Nakano, T.Takahashi, K.Fujihara, K.Tanaka,
S.Sakoda: Astrocytic necrosis is induced by anti-aquaporin4 antibody-positive serum, Neuroreport., 20:508-512,
2009.

0360B005(T.Tani), K.Sakimura, M.Tsujita, T.Nakada, M.Tanaka, M.Nishizawa, K.Tanaka: Identification of binding sites foranti-aquaporin4 antibodies in patients with neuromyelitis optica, J. Neuroimmunol., 211:110-113, 2009.

－ 52 －

0360B006(M.Tanaka), K.Tanaka, M.Komori: Interferon-β1ｂ Treatment in Neuromyelitis Optica, Eur. Neurol., 62：167170, 2009.

0360B007(K.Yanagawa), I.Kawachi, Y.Toyoshima, A.Yokoseki, M.Arakawawa, A.Hasegawa, T.Ito, N.Kojima, R.Koike,
K.Tanaka, T.Kosaka, Chun -Feng Tan, A.Kakita, K.Okamoto, M.Tsujita, K.Sakimura, H.Takahashi, M.Nishizawa:
Pathologic and immunologic profiles of a limited form of neuromyelitis optica with myelitis, Neurology, 73:16281637, 2009.

0360B008(A.MM), T.Kasai, Y.Tashiro, Hui Qin Xing, H.Shirahama, M.Mitsuda, T.Suetsugu, K.Tanaka, M.Osame, S.Izumo:
CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration, J. Neuroimmunol.,
208:136-140, 2009.

0360B009(M.Takagi), K.Tanaka, T.Suzuki, A.Miki, M.Nishizawa, H.Abe: Anti-aquaporin-4 antibodypositive optic neuritis,
Acta Ophthalmol (Copenh)., 87:562-566, 2009.

0360B010(M.Nakamura), H.Houzen, M.Niino, K.Tanaka, H.Sasaki: Relationship between Barkhof criteria and the clinicalfeatures of multiple sclerosis in northern Japan, Mult.Scler, 15:1450-1458, 2009.

0360B012

M.Nakata: Useful laboratory parameters in blood and CSF for evaluation of pathological processes in patients withacute viral infection of the CNS, J. Kanazawa. Med. Univ., 34:101-106, 2009 (in Japanese) .

Reviews
0360C001

K.Tanaka: Anti-aquaporin 4 antibodies in neuromyelitis optica, Neuro-Ophthalmology Japan, 26：185-189, 2009
(in Japanese) .

0360C002

K.Tanaka: Paraneoplastic Encephalopathy /Encephalitis, Neurological Therapeutics., 26:31-37, 2009 (inJapanese) .

0360C003

K.Tanaka: Anti-aquaporin4-antibody in optic neuritis, Ophthalmology., 51:431-436, 2009 (in Japanese) .

0360C009

K.Tanaka: Clinical Aspects and Epidemiology in Multiple Sclerosis/Neuromyelitis Optica and Anti-Aquaporin-4
Antibody, Journal of the eye., 26：1301-1306, 2009 (in Japanese) .

Case Reports
0360D001(S.Amemiya), M.Hamamoto, T.Kumagai, M.Ueda, Y.Katayama, K.Tanaka: Neuromyelitis optica preceded by brain
demyelinating episode, J Neuroimaging., 19:263-265, 2009.

0360D002(H.Nozaki), T.Shimohata, T.Kanbayashi, Y.Sagawa, S.Katada, M.Satoh, O.Onodera, K.Tanaka, M.Nishizawa: A
patient with anti-aquaporin 4 antibody who presented with recurrent hypersomnia,reduced orexin(hypocretin)level,and symmetrical hypothalamic lesions, Sleep Med., 10:253-255, 2009.

0360D003(T.Fukuda), H.Shiraishi, T.Nakamura, K.Tanaka, H.Nakamura, A.Tsujino, Y.Nishiura, T.Yoshimura, M.Motomura,
K.Eguchi: Efficacy of tacrolimus in Sjogren's syndrome-associated CNS disease with aquaporin-4 autoantibodies, J.
Neurol., 256:1762-1764, 2009.

Presentations at Conference
International Conference (Presentations)
0360I001

K.Tanaka, T.Tani, M.Tsujita, K.Sakimura, M.Tanaka, M.Nishizawa, M.Matsui: Determination of the Binding
Epitope of Anti-Aquaporin 4 Antibody, Annual Meeting of American Academy of Neurology, (Seattle, '09.04).

0360I002(M.Tanaka), K.Tanaka, M.Matsui, M.Tahara, T.Konishi: Asymptomatic enhancing brain lesions in Japanesepatients with multiple sclerosis and neuromyelitis optica, ECTRIMS Dusserdolf,Germany, (Dusserdolf, '09.09).

0360I003

A.Nagaishi, Y.Kitagawa, M.Matsui, T.Tani, M.Tsujita, K.Sakimura, K.Tanaka: Anti-aquaporin 4 antibody binding
epitopes and its co-relation to clinical subtypes of NMO, ECTRIMS Dusserdolf,Germany, (Dusserdolf, '09.09).

－ 53 －

0370

Department of Geriatric Medicine

Name

Field of Specialization

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis

Faculty
Title

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology
MURAI Hiroshi

Geriatrics, Gastroenterology, Dementia, Nutrition

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

ISHIGAMI Keiichiro

Geriatrics, Dementia

SAKAI Junta

Geriatrics, Gastroenterology

NOMURA Koji

Geriatrics, Circulation

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis

TAKATA MeikoGeriatrics

KATO Shouzaburo

Geriatrics, Hypertension, Atherosclerosis

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Reviews
0370C001

L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto: Silent
information regulator, sirtuin 1, and age-related diseases, Nat. Clin. Pract. Rheumatol., 9:7-15, 2009.

－ 54 －

Presentations at Conference
International Conference (Presentations)
0370I001

H.Murai, T.Nakahashi, Ｍ.Ａｔｓｕｍｉ, Ｉ.Toyota, Ｈ.Yano, K.Nomura, H.Tsuchiya, K.Iwai, S.Morimoto: The atrophyof parahippocampal gyrus and lipid metabolism. -A vsrad analysis of senile dementia-, 19th Iagg World Congress ofGerontology and Geriatrics, (Pａｒｉｓ, '09.07).

0370I002

T.Nakahashi, Ｍ.Atsumi, H.Murai, I.Toyota, Ｈ.Yano, K.Nomura, H.Tsuchiya, K.Iwai, S.Morimoto: Factors
influencing prognosis of the frail elderly, 19th Iagg World Congress of Gerontology and Geriatrics, (Paris, '09.07).

－ 55 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

NAKAMURA
Tsuneyuki

Pediatric cardiology

ITO Masatsune

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism.

KOBAYASHI Azusa

Neonatology

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology
AKITA Chisato

Pediatric cardiology

YAMAMURA Junichi

Peditric Psychosomatic Disorder，Infectious Disease of Childhood，Clinical Virology，Fast and Easy Detection System for Infectiousagent

FUJIKI Takuma

Pediatric nephrology

SATO Hitoshi

Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

NAGASAWA Mayumi Neonatology
OKADA Naoki

Pediatric hematology, Pediatric oncology

IKEDA TomomiChild neurology

HIRAMATSU Masayuki Pediatric allergy, Pediatric immunology
HORISAWA Torou

Pediatric hematology, Pediatric oncology

KITO Toshiyuki

Pediatric allergy, Pediatric immunology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(S.Okamoto), H.Ikawa, H.Fukumoto, H.Masuyama, K.Konuma, M.Kohno, T.Nakamura, H.Takahashi: Patentductus arterionaus flow patterns in the treatment of congenital diaphragmatic hernia, Pediatr. Int., 51:555-558,
2009.

0380B002

C.Kitaoka, T.Nakamura, T.Nakamura, H.Sato, Y.Saikawa: B-type natriuretic peptide as a marker of latent left
ventricular impairement in pediatric patients with bronchial asthma, J. Kanazawa. Med. Univ., 34:53-58, 2009.

－ 56 －

0380B003(Daisuke Tomizawa), Katsuyoshi Koh, Masahiro Hirayama, Takako Miyamura, Michiki Hatanaka, Y.Saikawa, Eiichi
Ishii: Outcome of Recurrent or Refractory Acute Lymphoblastic Leukemia in Infants With MLL Gene
Rearrangements: A Report From the Japan Infant Leukemia Study Group, Pediatr Blood Cancer, 52:808-813,
2009.

0380B004

T.Nakamura, T.Arai, H.Kitano, K.Ohta, S.Sakazume, T.Kanaya, S.Hirabuki, H.Ueno, M.Kubo, A.Yachie, M.Inoue,
Y.Saikawa: Current Management of Prenatally Diagnosed Congenital Heart Disease in Ishikawa Prefecture,
Hokuriku Japanese Journal of Public Health., 35(2):, 2009 (in Japanese) .

0380B005

T.Akai, K.Torigoe, J.Yamamoto, S.Siraga, K.Yamamoto, H.Iizuka, S.Kawakami, Y.Saikawa: Are we too slow indiagnosing and operating for craniosynostosis?, Nervous system in children., 34：380-384, 2009 (in Japanese) .

0380B006

Y.Hayashi, T.Nakamura, M.Oguri, C.Akita, C.Kitaoka, H.Sato, T.Nakamura, Y.Saikawa: The Association ofAllergy in Kawasaki Disease, Progress in Medicine, 29:1655-1658, 2009 (in Japanese) .

0380B007

T.Kito, T.Nakamura, Y.Hayashi, T.Nakamura, T.Maruoka, Y.Saikawa: Antipyretic analysis of Mao-to for treatmentof type A influenza infection in children, Japanese journal of pediatrics., 62:2213-2217, 2009 (in Japanese) .

0380B008

M.Ito, N.Okada, A.Yamamoto, H.Takahashi, Y.Saikawa: Analyses of New Outpatients who had a Chief Complaintof Short Stature in a Single Institution and the Significance of Medical Screening for Short Stature, Hokuriku
Japanese Journal of Public Health., 36:6-9, 2009 (in Japanese) .

0380B009(A.Yachie), M.Mayumi, Y.Adachi, T.Nakamura: Analytical evaluation of current medical practice for childhood
bronchial asthma in hokuriku district based on questionnaires to the parents, Jpn. j. pediatr. allergy clin. immunol.,
23:103-112, 2009 (in Japanese) .

0380B010

T.Nakamura, M.Nakagawa, M.Hiramatsu, T.Kito, Y.Matsue, Y.Hayashi, T.Nakamura, Y.Saikawa: A questionnaire
survey for food allergy in hospital diet, Jpn. j. pediatr. allergy clin. immunol., 23:659-664, 2009 (in Japanese) .

Case Reports
0380D001(K.Watanabe), K.Uese, O.Higuchi, T.Futatani, N.Yoshimura, T.Nakamura, F.Ichida: Three-Dimensional Computed
Tomographic Findings of Bilateral Tracheal Bronchus, Pediatr. Cardiol., 30:87-88, 2009.

0380D002(K.Tamura), H.Kaneda, M.Miura, T.Horisawa, Y.Saikawa: Langerhans cell histiocytosis of the thoracic spine in achild:a case report, Japanese Journal of Pediatric Oncology., 46:207-211, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0380I001

T.Nakamura: B-type natriuretic peptide as a marker of latent left ventricular impairment in pediatric patients withbronchial asthma,, 5TH WORLD CONGRESS of paediatric Cardiology and Cardiac Surgery,, (Australia, '09.06).

0380I002

T.Akai, K.Okamoto, S.Siraga, K.Yamamoto, T.Iida, O.Tachibana, H.Iizuka: Intraparenchyma tumor biopsy byneuroendoscope under navigation, 9th International conference on cerebrovascular surgery, (Nagoya, '09.11).

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0390

Department of Neuropsychiatry

Name

Field of Specialization

JIBIKI Itsuki

Shizophrenia，Epilepsy，Brain imaging，Psychopharmacology，Senile
Demenｔia，Senile Psychosis

KUBOTA Takashi

Schizophrenia，Psychopharmacology，Epilepsy

IWASAKI Shinzo

Psycho Physiology，Neuropsy Chology，Brain Imaging

Faculty
Title

WATANABE Kenichiro Neuropsychology，Neuropharmacology
KITAMOTO Fukumi

Psychotherapy，Clinical Psychology

KOIZUMI Hazuki

Clinical Psychology，Cognitive-behaviora ltherapy

NANNO Hisatoshi

Schizophrenia

HIROYASU Kiwamu

Molecular Psychiatry，Schizophrenia, Epilepsy

KOSEKI Youju

Brain imaging

MONKAWA Tomomi

Psychopharmacology，Neuropsychology

SHIMIZU Satoru

Ｂｒａｉｎ imaging

MASUDA Shinji

Schizophrenia

MONKAWA Akikazu

Brain imaging，Schizophrenia

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001(Y.Sugiura), F.Nakatsu, K.Hiroyasu, A.Ishii, S.Hirose, M.Okada, I.Jibiki, H.Ohno, S.Kaneko, Y.Ugawa: Lack ofpotassium current in W309R mutant KCNQ3 channel causing benign familial neonatal convulsions(BFNC), EpilepsyRes., 84:82-5, 2009.

0390B003

Y.Koseki: Study on cerebral activation areas during repetition with functional MRI in normal adults, J. Kanazawa.
Med. Univ., 34:114-123, 2009 (in Japanese) .

－ 58 －

0390B004(H.Nakagawa), S.Iwasaki, H.Nanno, T.Nakada, M.Nagai, K.Watanabe: Long-term follow-up of a patient withendogenous juvenile-asthenic insufficiency syndrome: An attempt at disease grading and therapeutic approaches,Japanese Journal of Clinical Psychiatry., 38:1759-1768, 2009 (in Japanese) .

Others
0390F001(K.Maruyama), K.Nakamura, M.Nashimoto, F.Kitamoto, M.Oyama, Y.Tsuchiya, M.Yamamoto: Bone fracture inphysically disabled children attending schools for handicapped children in Japan, Environ. Health Perspect., 21:50,
2009.

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0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title(Additional Post)(Additional Post)

Name

Field of Specialization

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

WATANABE Naoto

Nuclear Medicine.

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

YOKOTA Hajime

Gastrointestinal Radiology, MR Spectroscopy

TANIGUCHI Mitsuru

Cardiac Nuclear Medicine

KUGINUKI Yasuaki

Diagnostic Imaging

KONDO Tamaki

Diagnostic Imaging.

OOTA Kiyotaka

Radiation Therapy

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging.
KITADATE Masataka Diagnostic Imaging,
DOAI Mariko

Diagnostic Imaging,

TOYOTA Ichiro

Diagnostic Imaging,

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

M.Matoba, M.Kitadate, T.Kondo, H.Yokota, H.Tonami: Depiction of hypervascular hepatocellular carcinoma with
64-MDCT:comparison of moderate-and high-concentration contrast material with and without saline flush, AJR
Am J Roentgenol, 193:738-744, 2009.

0400B002

K.Higashi, T.Sakuma, K.Ito, S.Niho, Y.Ueda, T.Kobayashi, R.Sekiguchi, T.Takahashi, T.Kato, H.Tonami:
Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEAlevel:identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma, Eur.
J. Nucl. Med. Mol. Imaging, 36:373-381, 2009.

0400B003

M.Sagawa, K.Higashi, K.Usuda, H.Aikawa, Y.Machida, M.Tanaka, M.Ueno, T.Sakuma: Curative wedge resection
for non-invasive bronchioloalveolar carcinoma, Tohoku J. Exp. Med., 217:133-137, 2009.

－ 60 －

Presentations at Conference
International Conference (Presentations)
0400I001

T.Kondo, M.Kitadate, M.Matoba, H.Yokota, H.Tonami: Experimental study on the evaluation of early therapeutic
effect after irradiation using high-resolution MRI and 1H-MRS, European Society for Magnetic Resonance in
Medicine and Biology(ESMRMB), (Turkey, '09.10).

0400I002

H.Yokota, M.Doai, M.Matoba, H.Tonami, Y.Nagao: In vitro proton MR spectroscopy for evaluation of humanbronchioalveolar carcinoma and lung adenocarcinoma, European Society for Magnetic Resonance in Medicine andBiology(ESMRMB), (Turkey, ‘09.10).

－ 61 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

AKITA Toshiaki

Cardiovascular surgery

SHIKATA Hiroo

Vascular surgery

HIDA Kenji

Vascular surgery

NAGAYOSHI Yasuhiro Cardiovascular surgery(Additional Post)

KOBATA Takashi

Vascular surgery

KANNO Masaaki

Cardiovascular surgery

NISHIZAWA Hisateru Cardiovascular surgery
YOKOTE Jun

cardiovascular surgery

NONAKA Toshimichi

Cardiovascular surgery

KIYOSAWA Jun

Cardiovascular surgery

NOGUCHI Yasuhisa

Cardiovascular surgery

MIZUNO Fumito

Cardiovascular surgery

MIKAMI Naofusa

cardiovascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Presentations at Conference
International Conference (Presentations)
0410I001

T.Kobata, F.Mizuno, N.Mikami, J.Kiyosawa, Y.Noguchi, J.Yokote, Y.Nagayoshi, K.Hida, H.Shikata, T.Akita: A
case with abdominal aortic aneurysm complicated by renal dysfunction in whom an endovascular aneurysm repair
was implanted successfully using carbon dioxide angiography, The 10th Annual Congress of Asian Society for
Vascular Surgery, (Busan, ‘09.10).

0410I002

J.Yokote, T.Kobata, N.Mikami, F.Mizuno, Y.Noguchi, J.Kiyosawa, Y.Nagayoshi, K.Hida, H.Shikata, T.Akita: A
case of thoracic endovascular aneurysm repair with extra-ana-tomical bypass, The 10th Annual Congress of AsianSociety for Vascular Surgery, (Busan, ‘09.10).

－ 62 －

0420

Department of Surgical Oncology

Name

Field of Specialization

KOSAKA Takeo

Surgical treatment of gastric cancer

NOGUCHI Masakuni

Surgery of breast cancer

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

NAKANO Yasuharu

Surgery of breast cancer

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

OMOTE Kazuhiko

Surgical treatment of gastric cancer

KINAMI Shinichi

Surgical treatment of gastric cancer

Faculty
Title

YOSHITANI Shinichiro Surgery of colorectal cancer
TANAKA Yumiko

Surgery of colorectal cancer

FUNAKI Hiroshi

Surgical treatment of gastric cancer

HASEGAWA Taisuke Surgery of hepatobiliary diseases
YOKOI Miki

Surgery of breast cancer

KURODA Masatoshi

Surgery of colorectal cancer

HOSOKAWA Kenzo

Surgery of digestive diseases

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research・ A treatment strategy for advanced pancreato-biliary cancer, based on the pattern of tumor invasion
・ Investigation concerning laparoscopic surgical procedure for safe and secure operation, and its establishment.
・ Study of generalization and standardization for laparoscopic surgery in the gastrointestinal disease.
・ Study of safeness in the laparoscopic surgery for malignant disease and functional preserving laparoscopic operation.
・ Study on the education and training for laparoscopic surgery.
・ Introduction of the recently evolving engineering and robotics to laparoscopic surgery.

Publications
Originals
0420B001

Shin-ichiro Yoshitani, Shigeki Takashima: Efficacy of postoperative UFT (Tegafur /Uracil) plus PSK therapies inelderly patients with resected colorectal cancer, Cancer Biother. Radiopharm., 24:35-39, 2009.

0420B002

Masalkuni Noguchi, Masashi Inokuchi, Yo Zen: Complement of peritumoral and subareolar injection in breast
cancer sentinel lymph node biopsy, J. Surg. Oncol., 100:100-105, 2009.

－ 63 －

Reviews
0420C001

S.Kinami, T.Fujimura, S.Fushida, K.Oyama, H.Fujita, I.Ninomiya, T.Ohta: Gastric ESD with transnasal endoscope
assistance : An excellent application of the transnasal slim scope, Endoscopia Digestiva, 21:115-120, 2009 (inJapanese) .

0420C002

M.Noguchi, M.Yokoi, Y.Nakano: Axillary reverse mapping for breast cancer, J. Kanazawa. Med. Univ., 34:10-13,
2009 (in Japanese) .

Case Reports
0420D001

T.Fukuyama, H.Kawahara, M.Yamada, N.Hayashi, H.Yano, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase,
T.Arisawa, K.Omote, T.Nojima: A case of IL-6 producing malignant mesothelioma of abdomen withthrombocytosis, jpn. j. gastroenterol., 109：546-553, 2009 (in Japanese) .

0420D002

S.Yoshitani, K.Hosokawa, M.Yokoi, S.Kinami, K.Omote, N.Ueda, Y.Nakano, T.Kosaka: A case of anal canal
carcinoma with systemic lymph node metastases successfully treated by bevacizumab + mFOLFOX6 therapy,
Cancer & chemotherapy., 36:2229-2231, 2009 (in Japanese) .

0420D003

M.Yokoi, K.Hosokawa, H.Funaki, S.Yoshitani, S.Kinami, K.Omote, N.Ueda, Y.Nakano, T.Kosaka, H.Minato: Acase of retroperitioneal dedifferentiated liposarcoma successfully treated with IFM and CDDP, Cancer &chemotherapy., 36:2114-2116, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0420I001

S.Kinami, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, K.Omote, N.Ueda, Y.Nakano, T.Kosaka, K.Oyama,
S.Fushida, T.Fujimura, T.Ohta: Double tract with aboral pouch reconstruction (DTAP) after total gastrectomy, 8thInternational gastric cancer congress, (Kracow, '09.06).

0420I002

K.Hosokawa, S.Kinami, T.Kosaka: Possibility of minimized gastrectomy with selective lymphadenectomy for small
T2 advanced gastric cancer, 8th International gastric cancer congress, (Kracow, '09.06).

0420I003

K.Omote, S.Kinami, H.Imaizumi, K.Hosokawa, M.Yokoi, M.Ooba, H.Funaki, S.Yoshitani, N.Ueda, Y.Nakano,
T.Kosaka: Laparoscopic surgery for early gastric cancer - experience in our institute -, 11th World congress on
gastrointestinal cancer, (Barcelona, '09.06).

0420I004

S.Yoshitani, M.Yokoi, K.Omote, T.Kosaka: Postoperative adjuvant immunochemotherapy using PSK in combination
for colorectal cancer in the elderly, 11th World congress on gastrointestinal cancer, (Barcelona, '09.06).

0420I005

M.Yokoi, K.Hosokawa, H.Funaki, S.Yoshitani, K.Omote, S.Kinami, N.Ueda, Y.Nakano, T.Kosaka: Evaluation of
peritoneal cytology for colorectal cancer, 11th World congress on gastrointestinal cancer, (Barcelona, '09.06).

－ 64 －

0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

MATSUMOTO Tadami Hip surgery(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

FUJITA Takuya

Spinal surgery

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

OKUDA Tetsuhito

Spinal surgery

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

MAEOKA Hayato

TraumaICHISEKI Toru

Hip surgery

HOSOKAWA Hidetaka Spinal surgery
HATANO Eiju

Spinal surgery

MIAKI Kohei

Hip surgery

HIROMURA Kentaro

TraumaFUKUI Kiyokazu

Hip surgery

YASUDA Yoshihito

Spinal surgery

KITAMURA Kenji

Hip surgery

TAKADA Naruki

TraumaTOMIDOKORO Jun

Hip Surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we have been trying to elucidate the mechanism of degeneration of lumber disc. It has been reported that
apoptosis of vertebral disc cells occurs in the degenerative intervertebral disc. However, its molecular mechanism remains
to be defined. The gene expression of Bax and Bcl-2 was analyzed in degenerative intervertebral disc. As a result,mechanical stress of the disc induces apoptosis through a Bax, reducing the number of cells and the synthesis ofextracelular matrix proteins and resulting in the degeneration of the disc.

－ 65 －

Publications
Originals
0430B001

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Yamada, K.Fukui, T.Matsumoto: Minimum ten-year results of a porous
acetabular component for Crowe I to III hip dysplasia using an elevated hip center., J. Arthroplasty., 24:187-194,
2009.

0430B002

A.Kaneuji, K.Yamada, K.Hirosaki, M.Takano, T.Matsumoto: Stem subsidence of polished and rough double taper
stems. In vitro mechanical effects on the cement-bone interface, Acta Orthop., 80:270-276, 2009.

0430B003(K.Kawanabe), K.Ise, K.Goto, H.Akiyama, T.Nakamura, A.Kaneuji, T.Sugimori, T.Matsumoto: A new cementless
total hip arthroplasty with bioactive titanium porous-coating by alkaline and heat treatment: average 4.8-year
results., J. Biomed. Mater. Res. Part B Appl. Biomater., 90:476-481, 2009.

0430B007(K.Shintani), H.Kawano, A.Kaneuji: A fundamental study of UHMWPE line improvement that has impact cushion
ability, Japanese Journal of Clinical Biomechanics., 30:269-276, 2009 (in Japanese) .

0430B008(K.Hirosaki), K.Shintani, A.Kaneuji: Improvement of the canal fill ratio of custom-made artificial femoral stem. Geometrical design using a circular insert axis based on the proximal canal morphology-, Japanese Journal of
Clinical Biomechanics., 30:277-286, 2009 (in Japanese) .

0430B015

T.Mikami: Prophylactic effect of antioxidant vitamins against osteonecrosis after steroid administration in a rabbit
model, J. Kanazawa. Med. Univ., 34:87-92, 2009 (in Japanese) .

0430B016

S.Nakagawa: Rat osteonecrosis model created through single application of an oxidative stress inducer, J.
Kanazawa. Med. Univ., 34:107-113, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0430I001

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, J.Tomidokoro, K.Kitamura, T.Matsumoto: Stem subsidence of polishedand rough double taper stems and its mechanical effect on the cement, 76th Annual Meeting of American Academyof Orthopaedic Surgeons (AAOS 2009), (Las Vegas, '09.02).

0430I002

T.Okuda, T.Fujita, H.Hosokawa, T.Matsumoto: Clinical outcome of lumbar disc herniation in young patients up to
25 years of age, The International Society for the Study of the Lumbar Spine (ISSLS 2009), (Miami, '09.05).

0430I003

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, T.Matsumoto: Phase transformation and surface
roughness of retrieval new generation yttria-stabilized zirconia femoral heads after total hip arthroplasty, The 22nd
Annual Congress of the International Society for Technology in Arthroplasty (ISTA 2009), (Hawaii, '09.10).

0430I004

K.Kitamura, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, T.Matsumoto: Changes of bone mineral density after
cementless total hip arthroplasty with defferent types of proximal femoral canal, The 22nd Annual Congress of theInternational Society for Technology in Arthroplasty (ISTA 2009), (Hawaii, '09.10).

0430I005

T.Okuda, T.Fujita, A.Kaneuji, E.Hatano, T.Ichiseki, Y.Yasuda, T.Matsumoto: Incidence of spondylolysis,
spondylolisthesis and degenerative scoliosis of the lumbar spine in patients with osteoarthritis of the hip, SocieteInternationale de Chirurgie Orthopedique et de Traumatologie (Sixth SICOT), (Pattaya, '09.10).

0430I006

T.Okuda, T.Fujita, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: Clinical outcome of lumbar disc herniation inyoung patients (up to 25 yaars of age), Societe Internationale de Chirurgie Orthopedique et de Traumatologie(Sixth SICOT), (Pattaya, '09.10).

0430I007

T.Ichiseki, A.Kaneuji, T.Sugimori, K.Fukui, K.Kitamura, T.Mikami, S.Nakagawa, T.Matsumoto: Prophylactic effectof antioxidant vitamins against osteonecrosis after steroid administration in a rabbit model, Association Research
Circulation Osseous 15th International Symposiumon Bone Circulation (ARCO 2009), (Yokohama, '09.11)，ARCO
2009 Program, 50, 2009.

－ 66 －

0430I008

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, R.Kominami, H.Shinohara, T.Matsumoto: Glucocorticoid
induces micro-fat embolism in the rabbit: a scanning electron microscopic study, Association Research Circulation
Osseous 15th International Symposiumon Bone Circulation (ARCO 2009), (Yokohama, '09.11)，ARCO 2009
Program, 47, 2009.

0430I009

K.Kitamura, T.Ichiseki, A.Kaneuji, K.Fukui, T.Matsumoto: Prevention of steroid-induced osteonecrosis byglutathione in rabbit models, Association Research Circulation Osseous 15th International Symposiumon Bone
Circulation (ARCO 2009), (Yokohama, '09.11)，ARCO 2009 Program, 49, 2009.

－ 67 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of SpecializationIIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

TAKADA Hisashi

crebrovascular disease, head injury, interventional neurosurgery

IIDA Takaaki

spinal disease, peripheral nerve disease

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

SASAGAWA Yasuo

brain tumor

SIRAGA Syunsuke

general neurosurgery

YAMAMOTO Kenji

general neurosurgery

YAMAMOTO Jiro

general neurosurgery

TORIGOE Keiichiro

general neurosurgery

SAKAI Sotaro

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury－ 68 －

1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001(Y.Hirota), O.Tachibana, N.Uchiyama, Y.Hayashi, M.Nakada, D.Kita, T.Watanabe, R.Higashi, J.Hamada,
Y.Hayashi: Gonadotropin-releasing hormone(GnRH)and its receptor in human meningiomas, Clin. Neurol.
Neurosurg., 111:127-133, 2009.

0440B002

T.Akai, K.Torigoe, J.Yamamoto, S.Siraga, K.Yamamoto, H.Iizuka, S.Kawakami, Y.Saikawa: Are we too slow indiagnosing and operating for craniosynostosis?, Nervous system in children., 34：380-384, 2009 (in Japanese) .

Case Reports
0440D001

Y.Sasagawa, T.Akai, K.Yamamoto, T.Masuoka, S.Itou, M.Oohashi, H.Iizuka: Multiple cavernous hemangiomas ofthe skull associated with hepatic lesions -case report-, Neurol. Med. Chir. (Tokyo), 49:162-166, 2009.

0440D002

Y.Sasagawa, T.Akai, S.Itou, H.Iizuka: Gamma knife radiosurgery-induced cavernous hemangioma -case report-,
Neurosurgery, 64:1006-1007, 2009.

0440D003

K.Okamoto, O.Tachibana, K.Torigoe, T.Akai, H.Iizuka: Initial experience of stereotactic radiotherapy forcarniopharyngioma, Stereotactic Radiotherapy., 13：39-45, 2009 (in Japanese) .

Others
0440F003

T.Akai: Book & journal review -on the changing epidemiology of hydrocephalus-, Nervous system in children.,
34:348-349, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0440I001

O.Tachibana, Y.Sasagawa, K.Torigoe, K.Yamamoto, S.Siraga, K.Okamoto, T.Iida, T.Akai, H.Iizuka, A.Nakagawa,D.Koya: Expression of interleukin-1beta,interleukin-6, interleukin-12 and TNF alpha in human rathke cleft cysts A possible inducer of secondary hypophysitisassosiated with rathke cleft cyst-, The 11th International Pitutiary
Pathology Society(IPPS)Meeting, (Tokushima, '09.10).

0440I002

T.Akai, K.Okamoto, S.Siraga, K.Yamamoto, T.Iida, O.Tachibana, H.Iizuka: Intraparenchyma tumor biopsy byneuroendoscope under navigation, 9th International conference on cerebrovascular surgery, (Nagoya, '09.11).

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0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery
SHIMADA Kenichi

Plastic and Reconstructive Surgery

MORITA Reiji

Plastic and Reconstructive Surgery

KISHIBE Miyuki

Plastic and Reconstructive Surgery

YAMAMOTO Yasunori Plastic and Reconstructive Surgery
YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

HIMI Yuji

Plastic and Reconstructive Surgery

HARASHIMA Youto

Plastic and Reconstructive Surgery

NISHIO Akiko

Plastic and Reconstructive Surgery

MIYASHITA Matsuki

Plastic and Reconstructive Surgery

OKAMURA Ai

Plastic and Reconstructive Surgery

NAKAMURA Namiki

Plastic and Reconstructive Surgery

TAGUCHI Rie

Plastic and Reconstructive Surgery

DAIZO Haruhisa

Plastic and Reconstructive Surgery

MIYANAGA Toru

Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

－ 70 －

Publications
Originals
0450B001

N.Koizumi, T.Miyanaga, S.Kawakami, M.Shimasaki, Y.Ueda: Proliferetive and differentiative effects of basic
fibroblast grouwth factor(bFGF) on perichondium of rabbit's ear, Skin research., Special edition. 11：14-20, 2009
(in Japanese) .

0450B002

A.Komuro, M.Kishibe, Y.Yamamoto, S.Kawakami: Treatment for second-degree burn wounds using trafermin(Fiblast® Spray), Japanese journal of burn injuries., 35：27-39, 2009 (in Japanese) .

0450B003

T.Akai, K.Torigoe, J.Yamamoto, S.Siraga, K.Yamamoto, H.Iizuka, S.Kawakami, Y.Saikawa: Are we too slow indiagnosing and operating for craniosynostosis?, Nervous system in children., 34：380-384, 2009 (in Japanese) .

Case Reports
0450D002

R.Saurai, K.Shimada, S.Kawakami, M.Yamamoto: A case of gas gangrene following burn injury, Japanese journal ofburn injuries., 35：46-51, 2009 (in Japanese) .

－ 71 －

0460

Department of Pediatric Surgery

Name

Field of Specialization

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Faculty
Title

FUKUMOTO Hironori Pediatric surgery
KUWAHARA Tsuyoshi Pediatric surgery
OSHIKIRI Takahiro

Pediatric surgery

TAKAHASHI
Sadayoshi

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

M.Kohno, H.Ikawa, K.Konuma, H.Masuyama, H.Fukumoto, E.Ogawa, Takahiro Oshikiri, S.Takahashi: Comparisonof the postoperative bowel function between transanal endorectal pull-through and transabdominal pull-through for
Hirschsprung's disease:a study of the feces excretion function using an RI-defecogram, Pediatr. Surg. Int., 25:949954, 2009.

0460B002(S.Okamoto), H.Ikawa, H.Fukumoto, H.Masuyama, K.Konuma, M.Kohno, T.Nakamura, H.Takahashi: Patentductus arterionaus flow patterns in the treatment of congenital diaphragmatic hernia, Pediatr. Int., 51:555-558,
2009.

－ 72 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

SASAKI Hiroshi

cataract, epidemiology, uveitis.

KITAGAWA Kazuko(Additional Post)

KOJIMA Masami

ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics.
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration.

NAGAI Kouta

cataract, epidemiology,

KAWAKAMI Yutaka

cataract, thyroid ocular.

FUJITA Nobuyuki

uveitisYAGUCHI Hiromoto

corneal epithelium, glsucoma.

HAGIWARA Kenta

ocular infection

INAGAKI Shinsuke

ocular infection

OSADA Hiromi

cataract, ophthalmology

SHIBATA Naoko

cataract, ophthalmology

HATSUSAKA Natsuko ophthalmological optics

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 73 －

Publications
Originals
0470B001(A.Arnarsson), KF.Damji, H.Sasaki, T.Sverrinsson, F.Jonasson: Pseudoexfoliation in the Reykjavik eye study:fiveyear incidence and changes in related ophthalmologic variables, Am. J. Ophthalmol., 148:291-297, 2009.

0470B002

K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki: Assessment of pinguecuｌa andpterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey
in Shanxi, China, Rehabilitation science : memoirs of the Tohoku Bunka Gakuen University Faculty of Medical
Science & Welfare, Department of rehabilitation., 5:31-40, 2009.

0470B003

M.Kojima, M.Hanazawa, Y.Yamashiro, H.Sasaki, S.Watanabe, M.Taki, Y.Suzuki, A.Hirata, Y.Kamimura, K.Sasaki:
Acute ocular injuries caudes by 60-GHz millimeter-wave exposure, Health Phys., 97:212-218, 2009.

0470B004

M.Fukuda, H.Sasaki: Measurement of AQCmax of five diffeｒnt ophthalmic solution and discussion of its new
application, J Ocul Pharmacol Ther, 25:351-355, 2009.

0470B005

H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD on UV-B-Induced cataracts in
rats, Jpn. J. Ophthalmol., 53:531-535, 2009.

0470B006(K.A.Sasaki), Y.Osakabe, K.Miyata, S.Amano, M.Yamada, K.Kitagawa, K.Hirano, S.Kinoshita: What is this thingcalled "amyloidosi"?, Cornea, 28:80-83, 2009.

0470B007Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, Y.Shinomura, K.Imai, T.Saeki,
A.Azumi, S.Nakada, E.Sugiyama, S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano,
Y.Zen, M.Kaneko, K.Miyazaki, K.Tsubota, K.Eguchi, K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima,
S.Sugai, H.Umehara: Proposal for a new clinical entity,IgG4-positive multiorgan lymphoproliferative
syndrome:analysis of 64 cases of IgG4-related disorders, Ann. Rheum. Dis., 68:1310-1315, 2009.

0470B008

H.Sasaki: Obsevational cohort study : The Reykjavik eye study, Journal of the eye., 26:17-24, 2009 (in Japanese) .

0470B009

M.Fukuda, H.Sasaki: Cytotoxic effects of new quinolone antibiotic ophthalmic solutions nad nonsteroidal antiinflammatory ophthalmic solutions on cultured rabbit corneal cell line, Journal of the eye., 26:399-403, 2009 (inJapanese) .

0470B010

M.Fukuda, H.Sasaki: Cytotocic effect of ofluoxacin ophthalmic solutions and timolol maleate ophthalmic solutions
on cultured rabbit corneal cell line and ocular pharmacokinetics of ophthalmic solutions in rabbits, Journal of theeye., 26:977-981, 2009 (in Japanese) .

Case Reports
0470D001

S.Inagaki, K.Kitagawa, K.Nagai, K.Hagiwara, H.Sasaki: An infant case of acute purulent dacryoadenitis due to
MRSA, Journal of the eye., 26:1405-1408, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0470I001

J.Qu, H.Sasaki, Y.Sakamoto, E.Shibuya, K.Sasaki: Influence of watercleft on ocular higher order aberrations, The
Association for Research in Vision and Ophthalmology, (Florida, '09.05).

0470I002

M.Fukuda, N.Takahashi, M.Yoshikawa, M.Kojima, Y.Sakamoto, H.Sasaki: Monitoring real time recovery from
corneal disorder with a corneal resistance device in vivo, The Association for Research in Vision andOphthalmology, (Florida, '09.05).

0470I003

M.Kojima, T.Sakai, Y.Yamashiro, T.Matsuda, S.Watanabe, H.Shirai, K.Sasaki, H.Sasaki: Characteristics of oculartemperature rise under exposure to frequency (18-40 GHz), BIOEM, (Davos, '09.06).

－ 74 －

0470I004(T.Sakai), M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki, S.Watanabe, K.Sato: Development of measurement system
for MMW exposure to a rabbit, BIOEM, (Davos, '09.06).

0470I005(T.Taguchi), H.Sitou, S.Kurogi, Y.Suzuki, M.Kojima, T.Sakai, S.Watanabe, H.Sasaki, M.Taki: Visualization of
Temperature distribution change due to millimeter-wave exposure with micro-encapsulated thermo-chromic liquid
crystal, BIOEM, (Davos, '09.06).

0470I006(PJ.Whitcher), CH.Shiboski, SC.Shiboski, AM.Heidenreich, K.Kitagawa, S.Zhang, J.Zhao, S.Hamann, G.Larkin,
N.McNamara, JS.Greenspan, SC.Pflulgfelder, TE.Daniels: The clular sicca score (OOS) : A simplified quantitative
method for assessing Keratoconjunctivitis sicca (KCS) in patinents enrolled in the Sjogrem's international registry
called the Sjogren's international collaborative clinical alliance (SICCA), 10th International Symposium on Sjogren's
Syndrome, (France, '09.10).

0470I007

K.Kitagawa, M.Higuchi, H.Tsuchida, H.Sasaki, N.Tomosugi: Diagnostic potential of tear and serum proteomic
patterns in mikulicz's disease, 10th International Symposium on Sjogren's Syndrome, (France, '09.10)，2009.

0470I008(JP.Whitcher), SC.Pflugfelder, G.Larkin, A.Heidenreich, S.Hamann, S.Zhang, TE.Daniels, JS.Greenspan,
K.Kitagawa, CH.Shiboski, SC.Shiboski: A Quantitative Method for Assessing Keratoconjunctivitis sicca From the
Sjogren's Syndrome (SS) International Registry, American Academy of Ophthalmology, (San Francisco, '09.10).

0470I009

H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, Y.Yamashiro, K.Sasaki: UV exposure to the Eye as a function of solar
altitude, American Academy of ophtometry, (Florida, '09.11).

0470I010

N.Hatsusaka, Y.Sakamoto, E.Shibuya, N.Mita, H.Sasaki: Influence of nuclear opacity on intraocular higher-orderaberrations, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

0470I011

M.Kojima, Y.Yamashiro, T.Sakai, Y.Suzuki, K.Sasaki, H.Sasaki: Heat cataract by millimeter wave band exposureand thermal transport of aqueous humor, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'09.12).

0470I012

H.Sasaki, T.Abe, S.Furui, Y.Sakamoto, S.Suzuki, H.Koutake, K.Terasaki, T.Ishitake, N.Hayabuchi: The effects ofionization radiation exposure on crystalline lenses of interventional radiologist, US-Japan Cooperative Cataract
Research Group Meeting, (Hawaii, '09.12).

0470I013

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract -Reykjavik Eye Study:2008-, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

0470I014

M.Kojima, Y.Ishiba, Y.Iwai, K.Sasaki, H.Sasaki: Study of reflected Ight form the back side of lenses (Glasses or
Sunglasses), as a Penetration route into the Eye, US-Japan Cooperative Cataract Research Group Meeting,(Hawaii, '09.12).

0470I015

Y.Yamashiro, M.Kojima, A.Hirata, T.Sakai, S.Watanabe, M.Taki, Y.Sakamoto, K.Sasaki, H.Sasaki: Comparison oftemperature elevation in ocular tissue by 18-40 GHz radio-frequency exposure, US-Japan Cooperative Cataract
Research Group Meeting, (Hawaii, '09.12).

0470I016

E.Shibuya, Y.Sakamoto, N.Yamamoto, H.Sasaki: Influence of age and axial length on intraocular higher orderaberrations, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

－ 75 －

0480

Department of Otolaryngology

Faculty
Title

Name

Field of Specialization

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

MURATA Hideyuki

Rhinology, Head and neck surgery, Endoscopic surgery, Computer
aided surgery

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

HORIGUTI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

ISHIMASA Hiroshi

Head and neck surgery, rhinology, General otolaryngology

MIYAZAWA Toru

Basic otology research, Head and neck surgery

KITAMURA Miwa

Otolaryngology

SAKAI Aya

Sleep apnea, Otolaryngology

YAMADA Kanako

Audiology, Otolaryngology

YAMAMOTO Junpei

Otorhinolaryngology

Keywords of Researcholfaction and gustation, neurotology, tympanoplasty, cochlear implant, middle ear implant, virtual endoscopy, computeraided surgery, endoscopic nasal surgery, laser surgery, sleep apnea & snoar surgery, skull base surgery, head and necktumor surgery, molecular biology, oncology, laryngology, speech rehabilitation, acoustic neuroma surgery, navigation
surgery, tele-medicine, thyroid tumor surgery, virtual education for surgery

Outline of Research
Basic and clinical research for olfaction and gustation
Central mechanism of auduological function by MEG
Restration for phonation with Provox 2 prosthesis
Clinical reserach for snoar and sleep apnea
Research for Thyroid and parathyroid gland
Inner ear molecular biology
Clinical survey for Head and Neck tumor and Oncology

Publications
Originals
0480B001

H.Shiga, H.Toda, T.Kobayakawa, S.Saito, K.Hirota, T.Tsukatani, M.Furukawa, T.Miwa: Usefulness of curryodorant of odor stick identification test for Japanese in olfactory impairment screening, Acta Otolaryngol.,
129(Suppl.562):91-94, 2009.

0480B002

H.Shiga, K.Washiyama, K.Hirota, R.Amano, M.Furukawa, T.Miwa: Use of thallium transport to visualize functional
olfactory nerve regeneration in vivo, Rhinology., 47:460-464, 2009.

－ 76 －

0480B003

M.Kitamura, Y.Shimode, J.Yamamoto, T.Miyazawa, K.Yamada, T.Nakaizumi, A.Horiguchi, H.Tsuji, A.Sakai,
Y.Suzuka, H.Nakai: The pollen count of Cryptomeia japonica and its relations between the direction and velocity ofwind in Uchinada(2008), Pollen allergy and prevention., 26-35, 2009 (in Japanese) .

0480B005

H.Shiga, K.Washiyama, K.Ogawa, H.Yamaguchi, Y.Magata, R.Amano, M.Furukawa, T.Miwa: Olfactory Nerve
Imaging with SPECT/CT in Rats, Japanese Journal of Rhinology., 48：138-141, 2009 (in Japanese) .

0480B007(T.Inoue), H.Tsuji, T.Minami, T.Yamashita: Our experience of microvascular free tissue transfer in head and neckcancer reconstruction, Otolaryngology-head and neck surgery (Tokyo), 19：55-61, 2009 (in Japanese) .

Case Reports
0480D001

A.Sakai, Y.Shimode, H.Tsuji, Y.Masaki: Huge malignant lymphoma of the thyroid gland complicated by recurrent
esophageal and tracheal fistulas induced by chemotherapy, J. Kanazawa. Med. Univ., 34:72-76, 2009.

Presentations at Conference
International Conference (Key Note Lecture)
0480G001

T.Miwa: Diagnosis and management of olfactory dysfunction, 10th Taiwan-Japan Otolaryngology Head & Neck
Conference, (Taiwan, '09.12).

International Conference (Presentations)
0480I001

H.Shiga, J.Taki, Y.Wshiyama, R.Amano, K.Yagi, J.Furukawa, T.Miwa: Clinical imaging of thalium transport in thehuman olfactory nerve, 2009 World Molecular Imaging Congress (WMIC), (Montreal, '09.09).

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0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

MOCHIZUKI Takashi Medical mycology ， Dermatomycosis
TANABE Hiroshi

Medical mycology, Decubitns

KAWASAKI Masako

Medical mycology

WATANABE Seiji

Medical mycology

ABE Shinya

Skin tumor and growth factores

FUJII Toshiki

Dermatopathology

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

TAKEDA Kiminobu

Medical mycology

FUJITA Jun

Medical mycology

HASEI Maki

Skin tumor and growth factores，Medical mycology

TERADA Maiko

Dermatopathology

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartyping, electron microscopy, dermatopathology, skin tumor, decubitus, deep tissue injury

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Publications
Originals
0490B001

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, Basavaraj M.Hemashettar: Successful Mating of a Human Isolateof Arthroderma simii with a Tester Strain of A. vanbreuseghemii, Jpn. J. Med. Mycol., 50：15-18, 2009.

－ 78 －

0490B002

H.Ishizaki, M.Kawasaki, K.Anzawa, T.Mochizuki, Arunaloke Chakrabarti, Rataporn Ungpakorn, Haydee Torres
Guererro, Conchita Toriello, Robert Arenas: Mitochondrial DNA Analysis of Sporothrix schenckii in India Thailand,Brazil, Colombia, Guatemala and Mexico, Jpn. J. Med. Mycol., 50：19-26, 2009.

0490B003

K.Takeda, T.Ushigami, M.Nanbu, H.Tanabe, T.Mochizuki, A.Fukumura, Wun Bill Chen: Six Cases of Skin Damage
Related to Leakage from a Gastrostomy Catheter, Skin research., 8：31-35, 2009 (in Japanese) .

Reviews
0490C007

T.Mochizuki: Diagnosis of Cutaneous Fungal Infection, Jpn. J. Med. Mycol., 50：195-198, 2009 (in Japanese) .

0490C012

T.Mochizuki: Fungal infections and oter common skin diseases on the foot, 靴医学, 23：105111, 2009 (inJapanese) .

Case Reports
0490D001(A.Arakawa), N.Kanazawa, S.Tanaka, M.Yonezawa, Y.Miyachi, T.Mochizuki: Genotyping of Trichophyton
tonsurans isolate from a Japanese boy reveals infection in the USA, Clin. Exp. Dermatol., 34：630-632, 2009.

0490D002(N.Umemoto), Ｔ.Demitsu, M.Kakurai, K.Sasaki, R..Azuma, E.Iida, K.Yoneda, M.Kawasaki, T.Mochizuki: Twocases of cutaneous phaeohyphomycosis due to Exophiala jeanselmei: diagnostic significance of direct microscopicalexamination of the purulent discharge, Clin. Exp. Dermatol., 34：351-353, 2009.

0490D003

J.Hatta, M.Yanagihara, M.Hasei, S.Abe, H.Tanabe, T.Mochizuki: Case of multiple cutaneous granular cell tumors,
J. Dermatol., 36：504-507, 2009.

0490D006(E.Asakawa), M.Fujihiro, T.Mochizuki: A Case of Granuloma Trichophyticum(Majocchi) Mimicking Leontiasis in
Clinical Appearance, Nishinihon j. dermatol., 71：160-163, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0490H001

T.Mochizuki: Application of molecular diagnosis of cutaneous fungal infections, The17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0490H002

M.Kawasaki, H.Tanabe, T.Mochizuki: Mycoses in Asia EP-03-3, Dematiaceous fungus infections in East Asia –molecular biological aspects－, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).

International Conference (Presentations)
0490I001

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, K.Kamei, M.Fujihiro, H.Shinoda: Molecularepidemiology of Trichophyton tonsurans isolated in Japan between 2006 to 2008, The 17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0490I002(M.Hata), K.Tatsuno, Y.Suzuki, K.Tomita, K. Sugaya, K.Anzawa, T.Mochizuki: Successful treatment of
sporotrichosis with voriconazole, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).

0490I003

H.Tanabe, T.Mochizuki, M.Kawasaki, T.Ushigami, N.Masayuki: Tinea barbae caused by Microsporum canis, The
17th Congress of the International Society for Human and Animal Mycology, (Tokyo, '09.05).

0490I004(M.Tochigi), T.Ochiai, C.Mekata, H.Nishiyama, K.Yamanaka, K.Anzawa, M.Kawasaki: Sporotrichosis of the face by
autoinoculation associated with tacrolimus treatment, The 17th Congress of The International Society for Humanand Animal Mycology, (Tokyo, '09.05).

0490I005

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, B.Hemashettar: Arthroderma vanbreuseghemii is a synonym ofA.simii, The 17th Congress of The International Society for Human and Animal Mycology, (Tokyo, '09.05).

－ 79 －

0490I006

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, B.Hemashettar:: Mating among three teleomorphs of

Trichophyton mentagrophytes, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).
0490I007J. Hatta, T.Hatta, S.Miyagawa, Y.Kitahara, T.Hirota, K.Anzawa, T.Mochizuki: Quantitative image analysis ofeffects of antimycotic agents on the hyphal growth in Trichophyton rubrum, The 17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0490I008

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, K.Kamei, Y.Takahashi, M.Fujihiro, H.Shinoda:
Molecular epidemiology of Japanese isolates of Trichophyton tonsurans by PCR-RFLP analysis of non-transcribedspacer region of ribosomal RNA gene, The 4th Joint Meeting of Japanese Dermatological Association and AustralianCollege of Dermatologist, (Tokyo, '09.07).

－ 80 －

0500

Department of Urogenital Surgery

Name

Field of Specialization

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

TANAKA Tatsuro

kidney transplantation, endourology

Faculty
Title

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer
KAWAMURA Kenjikidney stone disease, urogenital cancer

MORIYAMA Manabu

kidney transplantation， kidney stone disease

SUGA Koudai

general urology

CHIKAZAWA Ippei

general urology

TOKUNAGA Kousuke general urology
TACHIBANA
Hiromichi

general urology

ISHII Takeo

general urology

MORITA Nobuyo

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001

K.Miyazawa, K.Aihara, R.Ikeda, M.Moriyama, K.Suzuki: cDNA macroarray analysis of genes in renal epithelial cells
exposed to calcium oxalate crystals, Urol. Res., 37:27-33, 2009.

0500B002

M.Moriyama, K.Suga, K.Miyazawa, T.Tanaka, M.Higashioka, K.Noda, M.Oka, M.Tanaka, K.Suzuki: Inhibitions ofurinary oxidative stress and renal calcium level by an extract of Quercus salicina Blume/Quercus stenophylla
Makino in a rat calcium oxalate urolithiasis model, Int. J. Urol., 16:379-401, 2009.

0500B003

K.Kawamura, N.Morita, K.Suzuki: Induction of catastrophic cell death in p53 siRNA-treated human fibroblast cellsby hyperthermia, Cytometry Res, 19:45-51, 2009 (in Japanese) .

Reviews
0500C002

K.Kawamura, K.Fujikawa: Evaluation of sub-G1 peak in mitotic catastrophe, Cytometry Res, 19:63-71, 2009 (inJapanese) .

－ 81 －

Case Reports
0500D001

K.Sato, Y.Ueda, K.Kawamura, K.Aihara, S.Katsuda: Plasmacytoid urothelial carcinoma of the urinary bladder: acase report and immunohistochemical study, Pathol. Res. Pract., 205:189-194, 2009.

－ 82 －

0510

Department of Obstetrics and Gynecology

Faculty
Title(Additional Post)

Name

Field of Specialization

MAKINODA Satoru

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines

FUJII Ryota

perinatal medicine, reproductive endocrinology

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

OKA Yasuko

perinatal medicine, reproductive medicine

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

FUJITA Satoko

perinatal medicine, reproductive medicine

SASAKURA Chihaya

perinatal medicine, perinatal diagnosis

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 83 －

Presentations at Conference
International Conference (Presentations)
0510I001

Oka Y, Makinoda S: Myometrial blood flow analysis in pregnant women with IUGR, 19th Wordl Congress on
Ultrasound in Obstetrics and Gynecology, (Hamburg, '09.09).

0510I002

Waseda T, Oka Y, Makinoda S: Myometrial blood flow analysis in pregnant women with IUGR, 19th Wordl
Congress on Ultrasound in Obstetrics and Gynecology, (Hamburg, '09.09).

0510I003

Tomizawa H, Makinoda S: Usefulness of G-CSF in the Treatment of Luteinized Unruptured Rollicle(LUF), XIX
World Congress of Gynecology and Obstetrics, (Cape Town, '09.10).

0510I004

Fujita S, Oka Y, Fujii R, Makinoda S: A case of primary uterine atypical polypoid adenomyoma(APA) recurring
after pregnancy and delivery, XIX World Congress of Gynecology and Obstetrics, (Cape Town, '09.10).

0510I005

R. Fujii, Tomizawa H, Fujita S, Oka Y, Takagi H, Sasagawa T, Makinoda S, Utsunomiya T: USEFULLNESS OF GCSF FOR LUF PATIENTS, The International Ovarian Conference 2009, (Tokyo, '09.12).

－ 84 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

TSUCHIDA Hideaki

Cardiovascular Effects of Anesthetics, Intravenous Anesthetics

SHIRAISHI Miharu

Cardiac Anesthesia, Cardiovascular Agents

NISHIIKE Satoshi

Cardiovascular effects of anesthetics, Volatile anesthetic

SUGIURA Soichiro

Influence of the endothelium in sepsis, Cardiovasucular effects ofultra-short acting β1-selective blocker

HORIUCHI Katsura

General anesthesia, Local anesthesia

KIDA Hiromasa

Anaphylaxis

YAMAOKA Yuko

General anesthesia, Local anesthesia

MAGARA Ayuko

General anesthesia, Local anesthesia

HIRAMATSU Akiko

General anethesia, Local anethesia

MURATA Yuriko

General anethesia, Local anethesia

HIRAMATSU Toshiaki General anethesia, Local anethesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, paraquat, sepsis, delayed neuronal death, apoptosis, inducible nitric oxide synthase, brainischemia, epidural blockade, cytochrome P-450, liver mitochondoria, nitric oxide, hypothermia

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined 1) the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole, and 2) the effects of transient forebrain ischemia on
apoptotic death of the hippocampal pyramidal neuron in Mongolian gerbil.

Publications
Originals
0520B001

H.Kida: The changes in mesenteric lymph flow during anaphylactic hypotension of anesthetized rets, J. Kanazawa.
Med. Univ., 34:154-159, 2009 (in Japanese) .

Reviews
0520C002

H.Nakajima, T.Wagatsuma, N.Nakaya, H.Tsuchida: Startup of multi-disciplinary team for palliative care in
Kanazawa Medical University Hospital, J. Kanazawa. Med. Univ., 34:68-71, 2009 (in Japanese) .

－ 85 －

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

YOSHMURA Hiroshi

temporomandibular joint disorders, stomatology, neuroscience

DEMURA Noboru

orthodontics, stomatology

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology
HONJOU Miho

Orthodontics.

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Presentations at Conference
International Conference (Presentations)
0530I001

H.Yoshimura, T.Sugai, N.Segami, N.Kato: Input frequency-and NMDA receptor activity-dependent determinationof signal-traveling routes between primary and secondary visual cortices, The 36th International Congress ofPhysiological Sciences, (Kyoto, '09.07)，"J.Physiol. Sci. Suppl,", 59:S284, 2009.

0530I002

T.Sugai, R.Yamamoto, Y.Ueta, H.Yoshimura, N.Kato: The endopiriform nucleus functionally connects the olfactoryand gustatory information the rat, The 36th International Congress of Physiological Sciences, (Kyoto, '09.07)，
J.Physiol. Sci. Suppl, 59:S202, 2009.

－ 86 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

WATOH Yukihiro

Emergency,Emergency medical syctem,Disaster Medicine,

MASHIBA Satoru

Emergency,Anaphylaxis

HAYASHI Nobuyuki

Emergency,

MURASAKA Kenshi

Emergency,Neurosurgery

MORITA Hideki

Emergency,

GOTO Tetsuro

Emergency,

FUKUZUMI Mari

Emergency,

MIZUNUMA Mariko

Emergency,

IWAI Junichi

Emergency,

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 87 －

0560

Department of Medical Oncology

Name

Field of Specialization

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

NAKAJIMA Hideo

Medical Oncology, Immunology, Molecular Biology

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

NAKAYA Naoki

Medical Oncology

Faculty
Title

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Books
0560A003

Y.Motoo, T.Shimasaki, T.Minamoto: Gemcitabine changes the gene expression in human pancreatic cancer
cells :search for new therapeutic molecular targets, Pancreatology:from Bench to Bedside, 33-38, Springer, Berlin,
2009.

0560A005

Y.Motoo: Japanese Herbal Medicine in Western-style Modern Medical System, Botanical Medicine in Clinical
Practice, 105-111, CABI, UK, 2009.

Publications
Originals
0560B001(W.Mai), K.Kawakami, A.Shakoori, S.Kyo, K.Miyashita, K.Yokoi, M.Jin, T.Shimasaki, Y.Motoo, T.Minamoto:
Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse
Transcriptase and Telomerase, Clin. Cancer Res., 15：6810-6819, 2009.

0560B002(QM.Zhou), S.Wamg, H.Zhang, YY.Lu, XF.Wang, Y.Motoo, SB.Su: The combination of baicalin and baicaleinenhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells, Acta Pharmacol. Sin., 30:16481658, 2009.

0560B003

Y.Motoo, I.Arai, I.Hyodo, K.Tsutani: Current status of Kampo (Japanese herbal) medicines in Japanese clinicalpractice guidelines, Complement Ther Med., 17：147-154, 2009.

－ 88 －

Reviews
0560C001(K.Miyashita), M.Nakada, K.Shakoori, Y.Ishigaki, T.Shimasaki, Y.Motoo, Kawakami K, T.Minamoto: An emerging
strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta., Anticancer Agents Med. Chem.,
9:1114-1122, 2009.

0560C006

H.Nakajima, T.Wagatsuma, N.Nakaya, H.Tsuchida: Startup of multi-disciplinary team for palliative care in
Kanazawa Medical University Hospital, J. Kanazawa. Med. Univ., 34:68-71, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0560H001

T.Shimasaki, Y.Motoo: Molecular analysis on gemcitabine-treated pancreatic cancer cells., 2nd Japan-Taiwan Joint
Symposium on Medical Oncology, (Taipei, '09.12).

International Conference (Presentations)
0560I001

T.Shimasaki, Y.Ishigaki, N.Nakaya, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo:
Therapeutic effect of gemcitabine plus GSK3β inhibitor on pancreatic cancer: basic analysis for future clinical
trial, The International Pancreatic Research Forum 2009, (Tokyo, '09.03).

0560I002

J.Yamakawa, Y.Motoo: The kampo medicines orengedokuto, bufutsushosan and boiogito have different activities toregulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles, 8th
meeting of the consortium for globalization of chinese medicine(CGCM), (London, '09.08).

0560I003

Y.Motoo: Systematic review of Japanese clinical practice guidelines: how are Kampo medicines described?, The 8th
Meeting of the Consortium for Globalization of Chinese Medicine 2009, (Nottingham, '09.08).

－ 89 －

0570

District medical

Faculty
Title

Name

Field of Specialization

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase.

SO Shihei

Cardiovascular distase , Diabetes Mellitus , Mental distase

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Reviews
0570C001

L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto: Silent
information regulator, sirtuin 1, and age-related diseases, Nat. Clin. Pract. Rheumatol., 9:7-15, 2009.

Case Reports
0570D001

M.Fukura, A.Saito, K.Ishigami, K.Konishi, M.Hasegawa, JL.Wu, H.Kawahara, T.Kanda, T.Kigoshi, N.Takekoshi:
Suicides in aged patients; Case reports and review of the literature, J. Kanazawa. Med. Univ., 34:14-16, 2009.

Presentations at Conference
International Conference (Presentations)
0570I001

T.Kanda, R.Chen, M.Hasegawa, T.Nakahashi, K.Iwai, S.Morimoto: Dual effect of PPARα activator on myocardialdamage in obese diabetic mice with viral myocarditis, 2010 Keystone Symposia Meeting Abstract Book, (Colorado,'10.01)，2010 Keystone Symposia Meeting Abstract Book.

－ 90 －

0610

Health Management Center

Faculty
Title

Name

Field of Specialization

TAKASE Shujiro

Gastroenterology

MATSUDA Yoshiro(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine(Additional Post)

YASUDA Yukio

evidence-based health care

KAWAHARA Hiromu Liver injury and oxidative stress(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine(Additional Post)

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

NAKANISHI Yumiko

Preventive medicine

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

KUGINUKI Yasuaki

hemodynamics

KUSAKA Kazuya

Radiology

OOTA Kiyotaka

Radiology

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, "stress, dietary habits", "nutrient intake, exercise"

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0610B001(R.Oka), K.Miura, M.Sakurai, K.Nakamura, KYagi, S.Miyamoto, T.Moriuchi, H.Mabuchi, M.Yamagishi, Y.Takeda,
S.Hifumi, A.Inazu, A.Nohara, MA.Kawashiri, J.Kobayashi: Comparison of waist circumference with body mass index
for predicting abdominal adipose tissue, Diabetes Res. Clin. Pract., 83:100-105, 2009.

0610B002(K.Asayama), T.Ohkubo, S.Yoshida, K.Suzuki, H.Metoki, A.Harada, Y.Murakami, Y.Ohashi, H.Ueshima, Y.Imai,
H.Nakagawa, The Japan Arteriosclerosis Longitudinal Study(JALS) group: Stroke risk and antihypertensive drug
treatment in the general population:the Japan arteriosclerosis longitudinal study, J.Hypertens., 27:357-364, 2009.

0610B003

K.Nakamura, F.Barzi, R.Huxley, TH.Lam, I.Suh, J.Woo, HC.Kim, VL.Feigin, D.Gu, M.Woodward, Asia pacificcohort studies collaboration: Does cigarette smoking exacerbate the effect of total cholesterol and high-density
lipoprotein cholesterol on the risk of cardiovascular diseases?, Heart, 95:909-916, 2009.

0610B004

M.Sakurai, K.Miura, T.Takamura, M.Ishizaki, Y.Morikawa, K.Nakamura, K.Yoshita, T.Kido, Y.Naruse, S.Kaneko,
H.Nakagawa: J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes:an 8year follow-up of velatively lean Japanese individuals., Diabet. Med., 26:753-759, 2009.

－ 91 －

0610B005(AP.Kengne), K.Nakamura, F.Barzi, TH.Lam, R.Huxley, D.Gu, A.Patel, HC.Kim, M.Woodward, on behalf of the
Asia Pacigic Cohort Study Collaboration: Smoking, diabetes and cardiovascular diseases in men in the Asia-Pacificregion, J Diabetes., 1:173-181, 2009.

0610B006(The Asia Pacific Cohort Studies Collaboration), RR.Huxley, K.Nakamura, TH.Lam, F.Barzi, D.Batty,
S.Czernichow, H.Ueshima, HC.Kim, JW.Wong, X.Fang, V.Feigin, M.Woodward: Impact of cigarette smoking on
the relationship between body mass index and coronary heart disease: a pooled analysis of 3264 stroke and 2706
CHD events in 378579 individuals in the Asia Pacific region, BMC Public Health., 9:294, 2009.

0610B007

Y.Hamazaki, K.Nakamura, K.Hirata, K.Ｔｅｒａｍｏｔｏ, M.Matsuda: What factors are Associated with Postnatal
Depression in japanese Women?, Hokuriku Japanese Journal of Public Health., 35:58-62, 2009 (in Japanese) .

0610B008

Y.Hamazaki, K.Nakamura, K.Hirata, K.Teramoto, M.Matuda: What factors are associated with postnatal
depression in Japanese women?, Hokuriku Japanese Journal of Public Health., 35:58-62, 2009 (in Japanese) .

0610B009

K.Kusaka: Angiotensin Ⅱ receptor blocker regulates the polarization of Th1 and Th2 immune responses of obese
mice with viral myocarditis, J. Kanazawa. Med. Univ., 34:1-9, 2009 (in Japanese) .

0610B010

M.Sakurai, K.Miura, K.Nakamura, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Relationship between
abdominal obesity, accumulation of metabolic abnormalities and risk of cardiovascular disease: An 11-year followup of middle-aged Japanese men, Japanese journal of cardiovascular disease prevention., 44:1-9, 2009 (inJapanese) .

Reviews
0610C001

K.Nakamura, R.Huxley, A.Ansary-Moghaddam, M.Woodward: The hazards and benefits associated with smoking
and smoking cessation in Asia: a meta-analysis of prospective studies, Tob. Control., 18: 345-353, 2009.

Case Reports
0610D002

T.Fukuyama, H.Kawahara, M.Yamada, N.Hayashi, H.Yano, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase,
T.Arisawa, K.Omote, T.Nojima: A case of IL-6 producing malignant mesothelioma of abdomen withthrombocytosis, jpn. j. gastroenterol., 109：546-553, 2009 (in Japanese) .

－ 92 －

0620

Department of Pathology

Faculty
Title

Name

Field of Specialization(Additional Post)

MINATO Hiroshi

Anatomical pathology, Laboratory medicine, Pathological study of
pulmonary and mediastinal lesion, Pathological study of head & necktumor.

(Additional Post)

KUROSE Nozomu

surgical pathology, molecular pathology(Additional Post)KINOSHITA Erikosurgical pathology, molecular pathology

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Outline of Research
1.Anatomical pathology, Laboratory medicine, Pathological study of pulmonary and mediastinal lesion, Pathological study ofhead & neck tumor.
2.cellular pathology.
3.molecular pathology.

－ 93 －

0630

Department of General Internal Medicine

Faculty
Title(Additional Post)

Name

Field of Specialization

YAMAKAWA Junichi

General medicine,Kampo medicine

KUSAKA Kazuya

Diaqnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer, earygastric cancer, eary colon cancer

MORIYA Junji

General medicine,Kampo medicine

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

K.Kusaka: Angiotensin Ⅱ receptor blocker regulates the polarization of Th1 and Th2 immune responses of obese
mice with viral myocarditis, J. Kanazawa. Med. Univ., 34:1-9, 2009 (in Japanese) .

Reviews
0630C001

L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto: Silent
information regulator, sirtuin 1, and age-related diseases, Nat. Clin. Pract. Rheumatol., 9:7-15, 2009.

Presentations at Conference
International Conference (Presentations)
0630I001

J.Yamakawa, Y.Motoo: The kampo medicines orengedokuto, bufutsushosan and boiogito have different activities toregulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles, 8th
meeting of the consortium for globalization of chinese medicine(CGCM), (London, '09.08).

－ 94 －

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer

Presentations at Conference
International Conference (Presentations)
0640I001

M.Yamada, H.Shiroeda, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Analysis of C-kit and pdgfrα genemutation in gastrointestinal stromal tumor of the small intestine, DDW 2009, (Chicago, '09.06).

－ 95 －

0650

Department of Rehabilitation Medicine

Faculty
Title

Name
KAGECHIKA Kenji(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

－ 96 －

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name
SAKUMA Tsutomu
SAGAWA Motoyasu
USUDA Katsuo(Additional Post)

Field of Specialization
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema.
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening.
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology,

AIKAWA Hirokazu

thoracic surgery, lung cancer, video assisted thoracoscopic surgery．

KANNO Masaaki

Thoracic surgery

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy－ 97 －

Publications
Originals
0660B001

M.Sagawa, C.Endo, M.Sato, Y.Saito, T.Sobue, K.Usuda, H.Aikawa, S.Fujimura, T.Sakuma: Four years experienceof the survey on quality control of lung cancer screening system in japan, Lung Cancer, 63:291-294, 2009.

0660B002

J.Xu, Z.Wang, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma: Endogenous catecholamine stimulates alveolar
fluid clearance in rats with acute pancreatitis, Respirology, 14:195-202, 2009.

0660B003(C.Endo), A.Miyamoto, A.Sakurada, H.Aikawa, M.Sagawa, M.Sato, Y.Saito, T.Kondo: Results of long-term followup of photodynamic therapy fpr roentgenoraphically occult bronchogenic squamous cell carcinoma, Chest.,
136:369-375, 2009.

0660B004

K.Higashi, T.Sakuma, K.Ito, S.Niho, Y.Ueda, T.Kobayashi, R.Sekiguchi, T.Takahashi, T.Kato, H.Tonami:
Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEAlevel:identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma, Eur.
J. Nucl. Med. Mol. Imaging, 36:373-381, 2009.

0660B005

M.Sagawa, K.Higashi, K.Usuda, H.Aikawa, Y.Machida, M.Tanaka, M.Ueno, T.Sakuma: Curative wedge resection
for non-invasive bronchioloalveolar carcinoma, Tohoku J. Exp. Med., 217:133-137, 2009.

Reviews
0660C001(C.Hamashima), T.Nakayama, M.Sagawa, H.Saito, T.Sobue: The Japanese guideline for prostate cancer screening,
Jpn. J. Clin. Oncol., 1-13, 2009.

0660C002

M.Sagawa, K.Usuda, H.Aikawa, Y.Machida, M.Tanaka, M.Ueno, T.Sakuma: Lung cancer screening and its efficacy,Gen. Thorac. Cardiovasc. Surg., 57:519-527, 2009.

0660C005(T.Nakayama), C.Hamajima, H.Saito, T.Sobue, M.Sagawa: Guideline for prostate cancer screening by the researchgroup for developing the cancer screening guideline, Japanese Association for Cancer Detection and Diagnosis.,
16:36-40, 2009 (in Japanese) .

Case Reports
0660D001

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, Y.Machida, T.Nojima, T.Terauchi, T.Sakuma: The multitude of cytologic
components in pulmonary pleomorphic carcinoma-A report of tow cases-, J. Jpn. Soc. Clin. Cytol., 48:220-225,
2009.

0660D002

M.Sagawa, Y.Ueda, H.Sakuma, Y.Yoshimisu, F.Matsubara, T.Sakuma: Organizing pneumonia with an enlarging
tumor-like lesion:immunohistochemical study, Jpn. J. THORACIC CARDIOVASC. SURG., 57:433-436, 2009.

0660D003

K.Usuda, M.Sagawa, H.Aikawa, M.Tanaka, Y.Machida, M.Ueno, ZX.Tong, T.Sakuma: Severe basal bronchialstenosis related to dissection of pulmonary ligament. Report of a case, J. Kanazawa. Med. Univ., 34:160-162,
2009.

0660D004

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, Y.Masaki, E.Kinoshita, T.Sakuma:
Complete resection of an advanced mediastinal nonseminomatous germ cell tumor with multiple distant metastases
after Douwn-staging by chemotherapy, Ｔhe Japanese journal of thoracic surgery., 62:545-551, 2009 (inJapanese) .
M.Tanaka, M.Ueno, Y.Machida, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: Descending necrotizing mediastinitis,
Ｔhe Japanese journal of thoracic surgery., 62:1073-1077, 2009 (in Japanese) .

－ 98 －

Presentations at Conference
International Conference (Key Note Lecture)
0660G001

T.Sakuma: Multidisciplinary treatment of thoracic malignant tumor, 2009 Shanghai Medical Association Society of
Pulmonary diseases proceedings of Annual meeting, (Shanghai, '09.04).

International Conference (Synposium)
0660H001

M.Sagawa: Lung cancer screening program in japan and its efficacy, CLC International Lung Cancer Symposium,(Incheon, '09.08).

－ 99 －

0670

Lifestyle-related Diseases Center

Title

Name

Field of Specialization(Additional Post)

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterosecretiol

Faculty

Physical physiology(The exercise testing and prescription from thephysiological and biochemical research), Effects of the anemia on thephysical activitiy, Exercise therapy for the lifestyle-related disease,
Training for health Medical Education.
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning(Additional Post)

TAMURA Nobuki(Additional Post)

HORI Ariyuki(Additional Post)

NAKANISHI Yumiko

Preventive medicine.

ITO Tomohiko

Endocrinology(Additional Post)

UENISHI Hiroaki

Cardiovascular Medicine

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology.

KITADA Munehiro

diabetes, hypertension.

KAMODA Sachikolifestyle-related disease, Preventive medicine.

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

－ 100 －

0680

Medical Genetic Center

Faculty
Title

Name

Field of Specialization

NIIDA You

genetic diagnosis, genetic counseling(Additional Post)

ITO Masatsune

child endocrinology(Additional Post)

SATO Hitoshi

clinical virology, child infectious disease

Keywords of Research
Medical genetics, Genetic services, Genetic counseling, Genetic testing, DNA diagnosis, Molecular diagnosis, Chromosomal
study

Outline of ResearchStudies and practices of useful methods of genetic concerning
Development of exhaustive and comprehensive genetic testing
Total health care of patients with genetic diseases－ 101 －

0690

Department of Endoscopy

Faculty
Title

Name
ITOU Tohru

URASHIMA Sachio

KAWAURA Ken

HAMADA Kazu

Field of Specialization
Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopicaltreatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopicaltreatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)－ 102 －

0700

Multidisciplinary Cancer Center

Title

Name

Field of Specialization(Additional Post)

TANAKA Tatsuro

Urology(Additional Post)

TSUJI Hiroyuki

Head & Neck Surgery(Additional Post)

MATOBA Munetaka

Radiation Oncology(Additional Post)

MASAKI Yasufumi

Hematology/Oncology(Additional Post)

OMOTE Kazuhiko

Surgical treatment of gastric cancer(Additional Post)

WASADA Tomoo

Reproductive medicine, perinatal medicine, gynecologic oncology(Additional Post)

OKAMOTO Kazuya

Brain tumor, stereotactic radiosurgery(Additional Post)

TSUCHIHARA
Katsuma

Clinical respiratory medicine(Additional Post)

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease

Faculty

Keywords of Researchout patient chemotherapy, clinical investigation, biomarker, multidisciplinary cancer

Outline of Research
Our main task is outpatient chemotherapy, which is requested by other Departments of the hospital. We are also involvedin clinical trials on chemotherapy, and in translational research using clinical samples such as blood and urine of patients.

Books
0700A003

Y.Motoo, T.Shimasaki, T.Minamoto: Gemcitabine changes the gene expression in human pancreatic cancer
cells :search for new therapeutic molecular targets, Pancreatology:from Bench to Bedside, 33-38, Springer, Berlin,
2009.

0700A005

Y.Motoo: Japanese Herbal Medicine in Western-style Modern Medical System, Botanical Medicine in Clinical
Practice, 105-111, CABI, UK, 2009.

Publications
Originals
0700B001(W.Mai), K.Kawakami, A.Shakoori, S.Kyo, K.Miyashita, K.Yokoi, M.Jin, T.Shimasaki, Y.Motoo, T.Minamoto:
Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse
Transcriptase and Telomerase, Clin. Cancer Res., 15：6810-6819, 2009.

0700B002(QM.Zhou), S.Wamg, H.Zhang, YY.Lu, XF.Wang, Y.Motoo, SB.Su: The combination of baicalin and baicaleinenhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells, Acta Pharmacol. Sin., 30:16481658, 2009.

0700B003

Y.Motoo, I.Arai, I.Hyodo, K.Tsutani: Current status of Kampo (Japanese herbal) medicines in Japanese clinicalpractice guidelines, Complement Ther Med., 17：147-154, 2009.

－ 103 －

Presentations at Conference
International Conference (Synposium)
0700H001

T.Shimasaki, Y.Motoo: Molecular analysis on gemcitabine-treated pancreatic cancer cells., 2nd Japan-Taiwan Joint
Symposium on Medical Oncology, (Taipei, '09.12).

International Conference (Presentations)
0700I001

T.Shimasaki, Y.Ishigaki, N.Nakaya, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo:
Therapeutic effect of gemcitabine plus GSK3β inhibitor on pancreatic cancer: basic analysis for future clinical
trial, The International Pancreatic Research Forum 2009, (Tokyo, '09.03).

0700I002

Y.Motoo: Systematic review of Japanese clinical practice guidelines: how are Kampo medicines described?, The 8th
Meeting of the Consortium for Globalization of Chinese Medicine 2009, (Nottingham, '09.08).

－ 104 －

School of Nursing

8010

Basic Nursing

Faculty
Title

Name

Field of Specialization

SAKAI Keiko

Proficiency and stressor of teachers in nursing.

SAKAI Keiko

Communication Skills

KIMOTO Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireKYUJI Kazuyo

Nursing Students and Proffessional Sprit

Keywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

－ 105 －

8030

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

KITAOKA Kazuyo

Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability

NAGAI Makie

Occupational Mental Health

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has published the Japanese version of the Maslach Burnout
Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support thosepeople with mental disabiltiy.

Publications
Originals
8030B001

K.Kitaoka-Higashiguti, Y.Morikawa, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Burnout andrisk factors for arteriosclerotic disease: follow-up study, J. Occup. Health, 51:123-131, 2009.

8030B002(M.Sasaki), K.Kitaoka, Y.Morikawa, H.Nakagawa: Relationship between stress coping and burnout in Japanesehospital nurses, J. Nurs. Manag., 17:359-365, 2009.

8030B003(R.Umanodan), Y.Kobayashi, M.Nakamura, K.Kitaoka, N.Kawakami, A.Shimazu: Effects of a worksite stressmanagement training program with six short-hour sessions, J. Occup. Health, 51:294-302, 2009.

8030B004

M.Nagai, K.Kitaoka, E.Hirayama: Explanatory approach of psychiatric out-patients' needs through the impressionof nursing students during simulation as out-patient, Journal of Japan Academy of Psychiatric and Mental HealthNursing., 18:20-27, 2009 (in Japanese) .

8030B005(Y.Ando), K.Kataoka, Y.Kobayashi, H.Okamura, K.Kitaoka: Development of a burnout causal model for nurses
caring for patients with intractable neurological illness, Journal of Japan Academy of Nursing Science., 29:3-12,
2009 (in Japanese) .

8030B006(H.Nakawaga), S.Iwasaki, H.Nanno, T.Nakada, M.Nagai, K.Watamabe: Long-term follow-up of a patient withendogenous juvenile-asthenic insufficiency syndrome: An attempt at disease grading and therapeutic approaches,Japanese Journal of Clinical Psychiatry., 38:1759-1768, 2009 (in Japanese) .

Others
8030F001

M.Nagai, Y.Hamazaki: Prevention of depression among the elderly:an elderly patient with transient depressive
symptoms after the Noto peninsula earthquake, J. So. Nurs. Pract., 21:65-68, 2009 (in Japanese) .

－ 106 －

Presentations at Conference
International Conference (Presentations)
8030I001(S.Kendall), K.Kitaoka, L.Bloomfield, J.Appleton, J.Petrie: A comparative study of the effect of group based
parenting support on parental stress and outcomes for children, The 4th International Conference on Community
Health Nursing Research, (Australia, '09.08).

8030I002

K.Kitaoka, S.Kendall, L.Bloomfield, J.Petrie, J.Appleton, H.Moto, N.Nakai, M.Nagai, K.Yoritsune, T.Hashimoto:
Effect of parenting support program 123Magic applied to Japanese families, The 1st International Nursing Research
Conference of World Academy of Nursing Science, (Kobe, '09.09).

8030I003

M.Nagai, K.Kitaoka: Changes in social distance of nursing students towards the mentally disabled as a result oflistening to narrative story of persons with schizophrenia, The 1st International Nursing Research Conference ofWorld Academy of Nursing Science, (Kobe, '09.09).

8030I004(K.Ohnishi), K.Kitaoka, L.Bowers, D.Stewart, M.Merwe, Y.Ohgushi, H.Tanaka, M.Nakano, H.Fujii: Comparison of
moral distress experienced by psychiatric nurses in Japan and the UK, The RCN 15th International Network for
Psychiatric Nursing Research Conference, (Oxford, '09.09).

8030I005(R.Umanodan), Y.Kobayashi, M.Nakamura, K.Kitaoka, N.Kawakami, A.Shimazu: Effects of a multi-component
worksite stress management training program: a controlled traial in Japan, The 8th International Conference on
Occupational Stress and Health, (Puerto Rico, '09.11).

－ 107 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing.

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring.

UCHIDA Maki

Cancer Nursing, Terminal Care.

KITAMURA Yoshiko

Cancer Nursing.

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease.

Keywords of Research
Nephrology Nursing, Transplant Nursing, Cronic Disease Nursing, Terminal Care, Cancer Nursing, Nursing Ethics

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001

S.Tamura, K.Shintani: Self-care and nursing interventions for the physical and psychological pain of chronic
dialysis patients, J. So. Nurs. Pract., 21：28-35, 2009 (in Japanese) .

8040B002

M.Nagai, K.Kitaoka, E.Hirayama: Explanatory approach of psychiatric out-patients' needs through the impressionof nursing students during simulation as out-patient, Journal of Japan Academy of Psychiatric and Mental HealthNursing., 18:20-27, 2009 (in Japanese) .

－ 108 －

8050

Nursing of the Elderly

Faculty
Title

Name

Field of Specialization

KOIZUMI Yumi

community/elderly unrsing science

HASHIMOTO Tomoe community/elderly nursing science

Keywords of Research
Nursing of the Elderly

Outline of Research
Verification of Nursing Care about Daily living activities and their communication of the elderly with Dementia,also,theeffectiveness of the elderly Dementia prevention on the basis Local residents.
The Study of General Principle of Florence Nightingale connected with Nurse's recognition and expression in Nursing
phenomenon.

Presentations at Conference
International Conference (Presentations)
8050I001

K.Kitaoka, S.Kendall, L.Bloomfield, J.Petrie, J.Appleton, H.Moto, N.Nakai, M.Nagai, K.Yoritsune, T.Hashimoto:
Effect of parenting support program 123Magic applied to Japanese families, The 1st International Nursing Research
Conference of World Academy of Nursing Science, (Kobe, '09.09).

8050I002

M.Nagai, K.Kitaoka: Changes in social distance of nursing students towards the mentally disabled as a result oflistening to narrative story of persons with schizophrenia, The 1st International Nursing Research Conference ofWorld Academy of Nursing Science, (Kobe, '09.09).

－ 109 －

8060

Child Nursing

Faculty
Title

Name

Field of Specialization

TSUDA Akiko

Pediatric Nursing

Keywords of Researchchild, parenting, parenting support, attachment, daily living life, biological rhythm

Outline of Research
The study on biological rhythm and life style in childhood.

－ 110 －

8070

Maternity Nursing

Faculty
Title

Name

Field of Specialization

OCHIAI Fumie

Maternity Health, Child Health, Midwifery.

SASANO Kyoko

Crinical nursing, Nursing education.

TSUBOMOTO Takiko
YAMAZAKI Chisato
YORITSUNE Kaoru

Life development nursing.

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Presentations at Conference
International Conference (Presentations)
8070I001

K.Kitaoka, S.Kendall, L.Bloomfield, J.Petrie, J.Appleton, H.Moto, N.Nakai, M.Nagai, K.Yoritsune, T.Hashimoto:
Effect of parenting support program 123Magic applied to Japanese families, The 1st International Nursing Research
Conference of World Academy of Nursing Science, (Kobe, '09.09).

8070I002

M.Nagai, K.Kitaoka: Changes in social distance of nursing students towards the mentally disabled as a result oflistening to narrative story of persons with schizophrenia, The 1st International Nursing Research Conference ofWorld Academy of Nursing Science, (Kobe, '09.09).

－ 111 －

8080

Community Nursing

Faculty
Title

Name

Field of Specialization

FUKUMA Kazumi

Community Health Nursing

SAKURAI Shihomi

Community Health Nursin

HAMAZAKI Yuko

public health nursing study of elder abuse

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, successful aging, activity of cmmunity
organization

Outline of Research
We aim at the research of community nursing that contributes to sustain and improve quality of life and health of people inthe community. We have been studying about community nursing-care activity, community nursing education, Healthpromotion, successful aging and elder abuse

Publications
Originals
8080B001

Yuko Hamazaki, Shunki Doda: Investigation of how to intervention and support of elder abuse at family
relationship, Family Nursing., 7:130-138, 2009 (in Japanese) .

8080B002

Y.Hamazaki, K.Nakamura, K.Hirata, K.Ｔｅｒａｍｏｔｏ, M.Matsuda: What factors are Associated with Postnatal
Depression in japanese Women?, Hokuriku Japanese Journal of Public Health., 35:58-62, 2009 (in Japanese) .

8080B003

Y.Hamazaki, K.Nakamura, K.Hirata, K.Teramoto, M.Matuda: What factors are associated with postnatal
depression in Japanese women?, Hokuriku Japanese Journal of Public Health., 35:58-62, 2009 (in Japanese) .

8080B004

Y.Hamazaki, K.Fukuma: Survey of the Physical,Mental,Social conditions of community-dewlling patients sufferingfrom ossification of the posterior longitudinal ligament(OPLL), Journal of Japan Academy of Home Care., 13:54-62,
2009 (in Japanese) .

8080B005

Y.Hamazaki, K.Fukuma: Factor analysis of subjective quality of life (QOL) of community-dwelling patients sufferingfrom ossification of the posterior longitudinal ligament(OPLL), J. J. Intrac. Ill. Nurs., 14:140-148, 2009 (inJapanese) .

Others8080F001

M.Nagai, Y.Hamazaki: Prevention of depression among the elderly:an elderly patient with transient depressive
symptoms after the Noto peninsula earthquake, J. So. Nurs. Pract., 21:65-68, 2009 (in Japanese) .

－ 112 －

Presentations at Conference
International Conference (Presentations)
8080I001

Y.Hamazaki, K.Fukuma, Y.Morikawa: Factor Analysis on Subjective Well-being in In-home Care of Patiants
suffering from Ossification of the posterior longitudinal Ligament in Japan, The 4th international conference oncommunity health nursing research, (Adelaide South Australia, '09.08)，The 4th international conference oncommunity health nursing research conference handbook, 247, 2009.

8080I002

S.Sakurai: The study on sleep status in family caregivers of patients with Alzheimer disease, The 6th Congress of
ASRS, (Osaka, Japan, '09.10)，ASRS/JSSR/JSC Joint Congress 2009 PROGRAM & ABSTRACTS, 238, 2009.

－ 113 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

KATOU Kinko

Home Care Nursing, Public Health Nursing, Psychiatric Mental
Health Nursing in Community

MAEDA Shukohome care , home health care nurse.

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
support

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
Practice and restructuring of the infection control edcation program for home visiting nurses－ 114 －

8100

Human Science

Faculty
Title

Name

Field of Specialization

ISHIBASHI Takaharu

Cardiovascular Pharmacology

OKADA Masato

Peripheral nerve surgery, Trauma

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

HONDA Ryumon

Environment and health, Epidemiology

FUJII Ryota

perinatal medicine, reproductive endocrinology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001

R.Naganuma, M.Sakurai, K.Miura, K.Yoshita, Y.Morikawa, T.Kido, H.Ueshima, H.Nakagawa, J.Stamler: Relation of
long-term body weight change to change in lipoprotein particle size in Japanese men and women:The INTRTMAP
Toyama study, Atherosclerosis, 206:282-286, 2009.

8100B002(Y.Suwazono), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, M.Dochi, K.Nogawa: Biological half-life of
cadmium in the urine of inhabitants after cessation of cadmium exposure, Biomarkers., 14:77-81, 2009.

8100B003

K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki: Assessment of pinguecuｌa andpterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey
in Shanxi, China, Rehabilitation science : memoirs of the Tohoku Bunka Gakuen University Faculty of Medical
Science & Welfare, Department of rehabilitation., 5:31-40, 2009.

8100B004

M.Kojima, M.Hanazawa, Y.Yamashiro, H.Sasaki, S.Watanabe, M.Taki, Y.Suzuki, A.Hirata, Y.Kamimura, K.Sasaki:
Acute ocular injuries caudes by 60-GHz millimeter-wave exposure, Health Phys., 97:212-218, 2009.

8100B005

K.Kitaoka-Higashiguti, Y.Morikawa, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Burnout andrisk factors for arteriosclerotic disease: follow-up study, J. Occup. Health, 51:123-131, 2009.

8100B006

T.Ishibashi, N.Nishizawa, M.Nakamoto, S.Liu, M.Yang, T.Miwa, I.Shinkawa, J.Yoshida, T.Kawada, M.Nishio:
Arteriovenous differences in NO2- kinetics in anesthetized rabbits, Biol.Pharm.Bull., 32:399-404, 2009.

－ 115 －

8100B007(M.Sasaki), K.Kitaoka, Y.Morikawa, H.Nakagawa: Relationship between stress coping and burnout in Japanesehospital nurses, J. Nurs. Manag., 17:359-365, 2009.

8100B008

M.Sakurai, K.Miura, T.Takamura, M.Ishizaki, Y.Morikawa, K.Nakamura, K.Yoshita, T.Kido, Y.Naruse, S.Kaneko,
H.Nakagawa: J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes:an 8year follow-up of velatively lean Japanese individuals., Diabet. Med., 26:753-759, 2009.

8100B009

H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD on UV-B-Induced cataracts in
rats, Jpn. J. Ophthalmol., 53:531-535, 2009.

8100B010

T.Lihua, Y.Sakai, K.Iwai, S.Katsuda: Effect of collagen tripeptide of typeⅠcollagen on migration, proliferation andcollagen synthesis of human aortic smooth muscle cells, J. Kanazawa. Med. Univ., 34:93-100, 2009.

8100B011

H.Oda, M.Nishijo, H.Nakagawa, Y.Morikawa, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Urinary metallothioneinlevels and mortality in residents exposed to cadmium in the environment, J. Kanazawa. Med. Univ., 34:148-153,
2009.

8100B012

Y.Masaki, L.Dong, N.Kurose, K.Kitagawa, Y.Morikawa, M.Yamamoto, H.Takahashi, Y.Shinomura, K.Imai, T.Saeki,
A.Azumi, S.Nakada, E.Sugiyama, S.Matsui, T.Origuchi, S.Nishiyama, I.Nishimori, T.Nojima, K.Yamada, M.Kawano,
Y.Zen, M.Kaneko, K.Miyazaki, K.Tsubota, K.Eguchi, K.Tomoda, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima,
S.Sugai, H.Umehara: Proposal for a new clinical entity,IgG4-positive multiorgan lymphoproliferative
syndrome:analysis of 64 cases of IgG4-related disorders, Ann. Rheum. Dis., 68:1310-1315, 2009.

8100B013

K.Tawara, M.Nishijo, R.Honda, S.Maruzeni, T.Seto, T.Kido, S.Saito, H.Nakagawa: Effects of maternal dioxin
exposure on newborn size at birth among Japanese mother-infant pairs, Environ. Health Prevent. Med., 14:88-95,
2009.

8100B014(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Estimation of benchmark rice cadmium doses as thresholdvalues for abnormal urinary findings with adjustment for consumption of Jinzu River water, Bull. Environ. Contam.
Toxicol., 83:102-107, 2009.

8100B015(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Influence of consumption of cadmium-polluted rice or
Jinzu River water on occurrence of renal tubular dysfunction and/or Itai-itai disease, Biol Trace Elem Res,
127:257-268, 2009.

8100B016(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido: Association of lifetime cadmium intake or drinking Jinzu
River water with the occurrence of renal tubular dysfunction, Environ. Toxicol., 24:421-428, 2009.

8100B017(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido, H.Nakagawa: Influence of drinking and/or cooking with
Jinzu River water on the development of Itai-Itai disease, Biol Trace Elem Res, 129:46-57, 2009.

8100B018(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial follow-up study on renal
handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a generallinear mixed model, Biol Trace Elem Res, 129:261-269, 2009.

8100B019(H.Suzuki), T.Kido, Y.Morikawa, H.Nakagawa, M.Ishizaki, Y.Naruse, M.Higashiyama, M.Dochi, Y.Suwazono,
K.Nogawa: The relationship between mental-health status and work-related factors in male Japanese overseas
employees, Journal of Tsuruma Health Society Kanazawa University, 33:21-33, 2009.

8100B027

M.Sakurai, K.Miura, K.Nakamura, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Relationship between
abdominal obesity, accumulation of metabolic abnormalities and risk of cardiovascular disease: An 11-year followup of middle-aged Japanese men, Japanese journal of cardiovascular disease prevention., 44:1-9, 2009 (inJapanese) .

Reviews
8100C001

L.Zeng, R.Chen, F.Liang, H.Tsuchiya, H.Murai, T.Nakahashi, K.Iwai, T.Takahashi, T.Kanda, S.Morimoto: Silent
information regulator, sirtuin 1, and age-related diseases, Nat. Clin. Pract. Rheumatol., 9:7-15, 2009.

－ 116 －

Others
8100F001(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Answer to the comments by Eric J. Grant et al. in "Radiation
unlikely to be responsible for high cancer rates among distal Hiroshima A-bomb survivors", Environ. HealthPrevent. Med., 14:250-253, 2009.

8100F002(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Hiroshima survivors exposed to very low doses of A-bomb primaryradiation showed a high risk for cancers, Environ. Health Prevent. Med., 14:209, 2009.

8100F003(M.Miyao), T.Watanabe, R.Honda, Y.Yamada: Answer to the comment by Yoshisada Shibata on "Hiroshima
survivors exposed to very low doses of A-bomb primary radiation showed a high risk for cancers", Environ. HealthPrevent. Med., 14:157-158, 2009.

Presentations at Conference
International Conference (Presentations)
8100I001

M.Fukuda, N.Takahashi, M.Yoshikawa, M.Kojima, Y.Sakamoto, H.Sasaki: Monitoring real time recovery from
corneal disorder with a corneal resistance device in vivo, The Association for Research in Vision andOphthalmology, (Florida, '09.05).

8100I002

M.Kojima, T.Sakai, Y.Yamashiro, T.Matsuda, S.Watanabe, H.Shirai, K.Sasaki, H.Sasaki: Characteristics of oculartemperature rise under exposure to frequency (18-40 GHz), BIOEM, (Davos, '09.06).

8100I003(T.Sakai), M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki, S.Watanabe, K.Sato: Development of measurement system
for MMW exposure to a rabbit, BIOEM, (Davos, '09.06).

8100I004(T.Taguchi), H.Sitou, S.Kurogi, Y.Suzuki, M.Kojima, T.Sakai, S.Watanabe, H.Sasaki, M.Taki: Visualization of
Temperature distribution change due to millimeter-wave exposure with micro-encapsulated thermo-chromic liquid
crystal, BIOEM, (Davos, '09.06).

8100I005

H.Murai, T.Nakahashi, Ｍ.Ａｔｓｕｍｉ, Ｉ.Toyota, Ｈ.Yano, K.Nomura, H.Tsuchiya, K.Iwai, S.Morimoto: The atrophyof parahippocampal gyrus and lipid metabolism. -A vsrad analysis of senile dementia-, 19th Iagg World Congress ofGerontology and Geriatrics, (Pａｒｉｓ, '09.07).

8100I006

T.Nakahashi, Ｍ.Atsumi, H.Murai, I.Toyota, Ｈ.Yano, K.Nomura, H.Tsuchiya, K.Iwai, S.Morimoto: Factors
influencing prognosis of the frail elderly, 19th Iagg World Congress of Gerontology and Geriatrics, (Paris, '09.07).

8100I007

Y.Hamazaki, K.Fukuma, Y.Morikawa: Factor Analysis on Subjective Well-being in In-home Care of Patiants
suffering from Ossification of the posterior longitudinal Ligament in Japan, The 4th international conference oncommunity health nursing research, (Adelaide South Australia, '09.08)，The 4th international conference oncommunity health nursing research conference handbook, 247, 2009.

8100I008

M.Kojima, Y.Yamashiro, T.Sakai, Y.Suzuki, K.Sasaki, H.Sasaki: Heat cataract by millimeter wave band exposureand thermal transport of aqueous humor, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'09.12).

8100I009

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract -Reykjavik Eye Study:2008-, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

8100I010

M.Kojima, Y.Ishiba, Y.Iwai, K.Sasaki, H.Sasaki: Study of reflected Ight form the back side of lenses (Glasses or
Sunglasses), as a Penetration route into the Eye, US-Japan Cooperative Cataract Research Group Meeting,(Hawaii, '09.12).

8100I011

Y.Yamashiro, M.Kojima, A.Hirata, T.Sakai, S.Watanabe, M.Taki, Y.Sakamoto, K.Sasaki, H.Sasaki: Comparison oftemperature elevation in ocular tissue by 18-40 GHz radio-frequency exposure, US-Japan Cooperative Cataract
Research Group Meeting, (Hawaii, '09.12).

－ 117 －

Medical Research Institute/Center for FDD-MB

0710

Medical Research Institute

Faculty
Title

Name

Field of Specialization

DATE Takayasu

Mechanisms of chromosome segregation and DNA repair.

Keywords of Research
Gene analysis, PKU-β(TLK1), PKU-α(TLK2), DNA repair, cell cycle, signal transduction, chromosome

Outline of Research
Our research is to clarify the function of nuclear protein kinases.
PKU-alpha/TLK2 and PKU-beta/TLK1. Much of the work in our laboratory has focused on identifiying the role of PKUbeta/TLK1 in cell proliferation.

－ 119 －

0740

Division of Human Genetics (Biochemistry)

Faculty
Title

Name
KUHARA Tomiko
SHINKA Toshihiro

INOUE Yoshito

Field of Specialization
Human metabolome analysis for diagnosis of metabolic disorders andpersonalized medicine
Chemical diagnosis of metabolic disorders by mass spectrometry(Tyrosinosis, Metabolic disorders of fatty acid beta oxidation,
Acylcarnitine analysis, Sulfated bile acids analysis)
Chemical diagnosis and follow up study for metabolic disorders (ureacycle disorders, prenatal diagnosis of organic acidemias, Canavan
disease, optical isomer analysis)

Keywords of Researchhuman genetics, metabolome, pharmacogenomics, nutrinogenomics, metabolomics, mass spectrometry, inborn errors of
metabolism, molecular diagnosis, organic acidemia, gas chromatography-mass spectrometry, chemical diagnosis, pilot studyof neonatal screening, prenatal diagnosis, personalized medicine, stable isotope dilution, tandem mass spectrometry,electrosplay ionization mass spectrometry, 5-fluorouracil toxicity, metabolic profiling, aminoacidemia/aminoaciduria, fatty
acid β-oxidation, carnitine, acylcarnitine

Publications
Originals
0740B001

T.Kuhara, M.Ohse, Y.Inoue, T.Shinka: Five cases of beta-ureidopropionase deficiency detected by GC/MS
analysis of urine metabolome, J Mass Spectrom, 44:214-221, 2009.

0740B002

T.Kuhara, M.Ohse, Y.Inoue, T.Shinka, Y.Okano, H.Shintaku, K.Hongou, T.Miyawaki, W.Morinobu, H.Tamai,
K.Omura: Urinary metabolic profile of phenylketonuria in patients receiving total parenteral nutrition andmedication, Rapid Commun. Mass Spectrom., 23:3167-3172, 2009.

Case Reports
0740D001(T.Kimura), K.Yasuda, Y.Obi, K.Kobayashi, T.Kuhara, Y.Isaka, E.Imai, H.Rakugi, T.Hayashi: Worsening kidney
function with a history of urolithiasis, Am. J. Kidney Dis., 53:37-39, 2009.

－ 120 －

0750

Division of Human Genetics (Clinical Medicine)

Faculty
Title

Name

Field of Specialization

TAKABAYASHI Haruo fetal medicine, DNA medicine
OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Keywords of Research
genetic counseling, genetic service, prenatal diagnosis, congenital abnormality

Presentations at Conference
International Conference (Presentations)
0750I001

H.Takabayashi, P.Yuditiya, M.Kita, K.Ikawa, A.Sekisawa, H.Chiba, M.Kitagawa: FDD-MB 2.0 System and Future,
CNAPS-Ⅳ Hong Kong, (Hong Kong, '09.11).

－ 121 －

0770

Division of Core Facility (Radioisotope Center)

Faculty
Title

Name

Field of Specialization

ISHIGAKI Yasuhito

Molecular and Cellular Biology

YAMASHITA
Masatoshi

Radiation Safety Management

Keywords of Research
RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis,
Energy-filtering electron microscopy, Element mapping, Ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, centrosome, tumor growth angiogenesis, micro RNA

Outline of Research
Quality control of genetic information

Publications
Originals
0770B001

T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ohta: Isolation of
N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens., J. Health Sci., 55：373-379,
2009.

0770B002(T.Kiba), Y.Kintaka, Y.Suzuki, E.Nakata, Y.Ishigaki, S.Inoue: Ventromedial hypothalamic lesions change theexpression of neuron-related genes and immune-related genes in rat liver., Neurosci. Lett., 455:14-16, 2009.

0770B003(T.Kiba), Y.Kintaka, Y.Suzuki, E.Nakata, Y.Ishigaki, S.Inoue: Gene Expression Profiling in Rat Liver After VMH
Lesioning., Exp. Biol. Med. (Maywood), 234:758-763, 2009.

Reviews
0770C001(K.Miyashita), M.Nakada, K.Shakoori, Y.Ishigaki, T.Shimasaki, Y.Motoo, Kawakami K, T.Minamoto: An emerging
strategy for cancer treatment targeting aberrant glycogen synthase kinase 3beta., Anticancer Agents Med. Chem.,
9:1114-1122, 2009.

Others
0770F002

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0770H001

Y.Ishigaki, T.Kurihara, S.Izumi: Visualization of the mRNA structure in human cells by immuno-electron
microscopy, 6th International symposium on electron microscopy in medicine and biology 2009, (Kobe, '09.09).

－ 122 －

International Conference (Presentations)
0770I001

T.Shimasaki, Y.Ishigaki, N.Nakaya, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo:
Therapeutic effect of gemcitabine plus GSK3β inhibitor on pancreatic cancer: basic analysis for future clinical
trial, The International Pancreatic Research Forum 2009, (Tokyo, '09.03).

0770I002

T.Takegami, M.Murakami, K.Sato, T.Ota, Y.Ishigaki: Isolation of Japanese encephalitis virus (JEV) in Ishikawa,Japan and analysis of gene expression in JEV-infected cells bymicroarray, 43rd Joint Working Conference on Viral
Diseases、US-Japan Cooperative Medical Science Program、 Philadelphia, (Philadelphia, '09.07).

－ 123 －

0780

Division of Core Facility (Experimental Animal Center)

Faculty
Title

Name

(Additional Post)

MATSUI Shinobu

Field of Specialization

Keywords of Researchcardiac function, echocardiography, myocardial metabolism, cell cycle control and immunopathology

Outline of Research
1. cardiac function, echocardiography, myocardial metabolism.
2. cell cycle control and immunopathology.

－ 124 －

0800

Division of Core Facility (High-Tech Research Center)

Faculty
Title

Name

Field of Specialization(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SUN Peng
TAKATA Takanobu

Analysis of mood disorder model mice in search for new therapeutic
approaches
Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
0800B001(K.Asayama), T.Ohkubo, S.Yoshida, K.Suzuki, H.Metoki, A.Harada, Y.Murakami, Y.Ohashi, H.Ueshima, Y.Imai,
H.Nakagawa, The Japan Arteriosclerosis Longitudinal Study(JALS) group: Stroke risk and antihypertensive drug
treatment in the general population:the Japan arteriosclerosis longitudinal study, J.Hypertens., 27:357-364, 2009.

0800B002

R.Naganuma, M.Sakurai, K.Miura, K.Yoshita, Y.Morikawa, T.Kido, H.Ueshima, H.Nakagawa, J.Stamler: Relation of
long-term body weight change to change in lipoprotein particle size in Japanese men and women:The INTRTMAP
Toyama study, Atherosclerosis, 206:282-286, 2009.

0800B003(K.Miura), H.Nakagawa, Y.Ohashi, A.Harada, M.Takagi, T.Koshiro, A.Takahashi, M.Nishinaga, F.Soejima,
H.Ueshima, for the Japan arteriosclerosis longitudinal study (JALS) group: Four blood pressure indexes and therisk of stroke and myocardial infarction in Japanese men and women: a meta-analysis of 16 cohort studies,
Circulation, 119:1892-1898, 2009.

0800B004(Y.Suwazono), T.Kido, H.Nakagawa, M.Nishijo, R.Honda, E.Kobayashi, M.Dochi, K.Nogawa: Biological half-life of
cadmium in the urine of inhabitants after cessation of cadmium exposure, Biomarkers., 14:77-81, 2009.

0800B005

K.Kitaoka-Higashiguti, Y.Morikawa, K.Miura, M.Sakurai, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Burnout andrisk factors for arteriosclerotic disease: follow-up study, J. Occup. Health, 51:123-131, 2009.

0800B006

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H.Nakagawa: Middle-aged Japanese women are resistant to obesityrelated metabolic abnormalities, Metab. Clin. Exp., 58:456-459, 2009.

0800B007(M.Sasaki), K.Kitaoka, Y.Morikawa, H.Nakagawa: Relationship between stress coping and burnout in Japanesehospital nurses, J. Nurs. Manag., 17:359-365, 2009.

0800B008

M.Sakurai, K.Miura, T.Takamura, M.Ishizaki, Y.Morikawa, K.Nakamura, K.Yoshita, T.Kido, Y.Naruse, S.Kaneko,
H.Nakagawa: J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes:an 8year follow-up of velatively lean Japanese individuals., Diabet. Med., 26:753-759, 2009.

－ 125 －

0800B009(DD.Nhu), T.Kido, R.Naganuma, N.Sawano, K.Tawara, M.Nishijo, H.Nakagawa, NN.Hung, LTH.Thom: A GIS studyof dioxin contamination in a Vietnamese region sprayed with herbicide, Environ. Health Prevent. Med., 14:353360, 2009.

0800B010(The emerging risk factors collaboration), ED.Angelantonio, N.Sarwar, P.Perry, S.Captoge, KK.Ray, A.Thompson,
AM.Wood, S.Lewington, N.Sattar, CJ.Packard, R.Collins, SG.Thompson, J.Danesh, H.Nakagawa: Major lipids,
apolipoproteins, and risk of vascular disease, JAMA, 302:1993-2000, 2009.

0800B011

H.Oda, M.Nishijo, H.Nakagawa, Y.Morikawa, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Urinary metallothioneinlevels and mortality in residents exposed to cadmium in the environment, J. Kanazawa. Med. Univ., 34:148-153,
2009.

0800B012

K.Tawara, M.Nishijo, R.Honda, S.Maruzeni, T.Seto, T.Kido, S.Saito, H.Nakagawa: Effects of maternal dioxin
exposure on newborn size at birth among Japanese mother-infant pairs, Environ. Health Prevent. Med., 14:88-95,
2009.

0800B013(T.Kido), K.Saito, R.Naganuma, C.Sakakibara, DD.Nhu, H.Suzuki, M.Nishijo, H.Nakagawa, K.Kusama, NN.Hung:
Association between dioxin concentrations in breast milk and dietary nutrient intake in Vietnam, Organohalogen
Compounds., 71:982-987, 2009.

0800B014(DD.Nhu), T.Kido, R.Naganuma, K.Saito, H.Suzuki, N.Kuroda, S.Honma, K.Honma, S.Maruzeni, M.Nishijo,
H.Nakagawa, NN.Hung, LTH.Thom: An epidemiological study on health effects by dioxin in Vietnam introductionof new "Hot Spot" area, Organohalogen Compounds., 71:890-895, 2009.

0800B015(E.Kobayashi), Y.Suwazono, M.Dochi, R.Honda, T.Kido, H.Nakagawa: Influence of drinking and/or cooking with
Jinzu River water on the development of Itai-Itai disease, Biol Trace Elem Res, 129:46-57, 2009.

0800B016(E.Kobayashi), Y.Suwazono, R.Honda, M.Dochi, M.Nishijo, T.Kido, H.Nakagawa: Serial follow-up study on renal
handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a generallinear mixed model, Biol Trace Elem Res, 129:261-269, 2009.

0800B017(DD.Nhu), T.Kido, R.Naganuma, K.Saito, H.Suzuki, N.Kuroda, S.Honma, PT.Tai, S.Maruzeni, M.Nishijo,
H.Nakagawa, NN.Hung, LTH.Thom: Hormone levels in the saliva of lactating Vietnamese mothers in a dioxin hotspot area, Journal of Tsuruma Health Society Kanazawa University, 33:59-66, 2009.

0800B018(H.Suzuki), T.Kido, Y.Morikawa, H.Nakagawa, M.Ishizaki, Y.Naruse, M.Higashiyama, M.Dochi, Y.Suwazono,
K.Nogawa: The relationship between mental-health status and work-related factors in male Japanese overseas
employees, Journal of Tsuruma Health Society Kanazawa University, 33:21-33, 2009.

0800B019

T.Takata, T.Hasegawa, T.Tatsuno, J.Datte, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ota: Isolation of

N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens, J. Health Sci., 55:373-379,
2009.
0800B020(K.Yoshita), M.Nakagawa, Y.Sugimori, K.Mira, M.Sakurai, T.Kami, Y.Arai, M.Nozue, R.Tomimatsu, H.Nakagawa,
H.Ishida: Effects of weight-reducing program conducted at work place with minimum burden of participants: A
program to prevent development of metabolic syndrome, mainly under the guidance of registered dieticians, Journalof the Japan Dietetic Association, 52:17-26, 2009 (in Japanese) .

0800B021

M.Sakurai, K.Miura, K.Nakamura, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Relationship between
abdominal obesity, accumulation of metabolic abnormalities and risk of cardiovascular disease: An 11-year followup of middle-aged Japanese men, Japanese journal of cardiovascular disease prevention., 44:1-9, 2009 (inJapanese) .

Reviews
0800C001(Emerging risk factors collaboation), S.Erpou, S.Kaptoge, PL.Perry, ED.Angeletonio, A.Thompson, IR.White,
SM.Marcovina, R.Collins, SG.Thompson, J.Danesh, H.Nakagawa, K.Miura: Lipoprotein(a) concentration and therisk of coronary heart disease, stroke, and nonvascular mortality, JAMA, 302:412-423, 2009.

－ 126 －

Others
0800F001

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H. Nakagawa: Abnormal liver function tests and metabolic syndromeis fatty liver related to risks for atherosclerosis beyond obesity?, Intern. Med., 48:1573-1574, 2009.

0800F013

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

－ 127 －

0900

Division of Cell Medicine

Faculty
Title

Name

Field of Specialization

FUJIKAWA Kohzaburo polyploid cells, cell cycle,transformation
MIYAGOSHI Minoru

Cell biology

Keywords of Research
polyploid cells, polyploidization, Meth-A cells, V79 cells, triploid cells, tetraploid cells, octaploid cells, H-1(ES)cells

Outline of Research
Study of polyploid cells

Publications
Originals
0900B001

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi: Cell cycle, morphology and pluripotency of octaploidembryonic stem cells in comparison with those of tetraploid and diploid cells, Hum. Cell., 22：64-71, 2009.

Reviews
0900C001

K.Kawamura, K.Fujikawa: Evaluation of sub-G1 peak in mitotic catastrophe, Cytometry Res, 19:63-71, 2009 (inJapanese) .

－ 128 －

0910

Division of Advanced Medicine

Faculty
Title

Name

Field of Specialization

MATSUI Shinobu

Clinical cardiology

TOMOSUGI Naohisa

Clinical Proteomics

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Keywords of Researchheart failure, cardiomyopathy, nerohumoral factor, immunity, autoantibody, spermatogenesis, cell cycle, epigenetics,
endocrine disruptors, meiosis

Outline of Research
1.Myocardial injury due to autoimmunity against G-protein-coupled receptor. Growing evidence suggested that G-proteincoupled receptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated
cardiomyopathy. Our study showed that specific removal of anti-G-protein coupled receptor autoantibodies improved
cardiac structure and function in experimental autoimmune cardiomyopathy.
2.Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.
However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has beendeveloped. Here, we employed surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOFMS) to analyze the expression of serum hepcidin in hemodialysis patients. Hepcidin-25 was found to accumulate in theserum of hemodialysis patients; this could contribute to the pathogenesis of renal anemia by decreasing the available ironfor hematopoiesis.
3.Histone modifications in meiotic prophase of spermatogenesis.

Publications
Originals
0910B001

T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugi, F.Takano, T.Ohta: Isolation of
N-acetylneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens., J. Health Sci., 55：373-379,
2009.

0910B002(JJ.Kroot), EH.J.M.Kemna, SS.Bansal, M.Busbridge, N.Campostrini, D.Girelli, RC.Hider, V.Koliaraki, A.Mamalaki,
G.Olbina, N.Tomosugi, C.Tselepis, DG.Ward, T.Ganz, JC.M.Hendriks, DW.Swinkels: Results of the firstinternational round robin for the quantification of urinary and plasma hepcidin assays: need for standardization,
Haematologica., 94:1748-1752, 2009.

0910B003(J.Kanda), T.Uchiyama, N.Tomosugi, M.Higuchi, T.Uchiyama, H.Kawabata: Oncostatin M and leukemia inhibitory
factor increase hepcidin expression in hepatoma cell lines, Int. J. Hematol., 90:545-552, 2009.

0910B004(T.Kamai), N.Tomosugi, H.Abe, K.Arai, K.Yoshida: Increased serum hepcidin-25 level and increased tumor
expression of hepcidin mRNA are associated with metastasis of renal cell carcinoma, BMC Cancer, 9：270, 2009.

0910B005(J.Kanda), C.Mizumoto, H.Kawabata, T.Ichinohe, H.Tsuchida, N.Tomosugi, K.Matsuo, K.Yamashita, T.Kondo,
T.Ishikawa, T.Uchiyama: Clinical significance of serum hepcidin levels on early infectious complications inallogeneic hematopoietic stem cell transplantation, Biol. Blood Marrow Transplant., 15:956-962, 2009.

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0910B006(H.Suzuki), K.Toba, K.Kato, T.Ozawa, N.Tomosugi, M.Higuchi, T.Kusuyama, Y.Iso, N.Kobayashi, S.Yokoyama,
N.Fukuda, H.Saitoh, K.Akazawa, Y.Aizawa: Serum hepcidin-20 is elevated during the acute phase of myocardial
infarction, Tohoku J. Exp. Med., 218：93-98, 2009.

0910B007(R.Sugimoto), N.Fujita, N.Tomosugi, H.Miyauchi, H.Tanaka, M.Takeo, N.Nakagawa, M.Iwasa, Y.Kobayashi,
M.Kaito, Y.Takei: Impaired regulation of serum hepcidin during phlebotomy in patients with chronic hepatitis C,
Hepatol. Res., 39：619-624, 2009.

0910B008

H.Okuyama, S.Kimura, H.Atsumi, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Imamura, H.Yamaya,
M.Asaka, N.Tomosugi, H.Yokoyama: The relationship between initial diagnosis and long-term prognosis in lupus
nephritis, Jpn. J. Nephrol., 51：44-50, 2009 (in Japanese) .

Others
0910F002

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0910I001

T.Shimasaki, Y.Ishigaki, N.Nakaya, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo:
Therapeutic effect of gemcitabine plus GSK3β inhibitor on pancreatic cancer: basic analysis for future clinical
trial, The International Pancreatic Research Forum 2009, (Tokyo, '09.03).

0910I002

Y.Masaki, N.Kurose, H.Iwao, A.Nakajima, M.Yamamoto, H.Takahashi, M.Kawano, T.Saeki, S.Matsui, A.Azumi,
S.Nishiyama, Y.Zen, T.Sumida, M.Kojima, T.Yoshino, S.Nakamura, N.Tomosugi, T.Takegami, S.Sugai, H.Umehara:
Clinico-pathological analysis of 107 cases of IgG4+MOLPS (IgG4-positive multi-organ lymphoprolife-rative
syndrome), 10th International symposium on Sjögren's syndrome, (BREST, '09.10).

0910I003

H.Yokota, M.Doai, M.Matoba, H.Tonami, Y.Nagao: In vitro proton MR spectroscopy for evaluation of humanbronchioalveolar carcinoma and lung adenocarcinoma, European Society for Magnetic Resonance in Medicine andBiology(ESMRMB), (Turkey, ‘09.10).

0910I004

K.Kitagawa, M.Higuchi, H.Tsuchida, H.Sasaki, N.Tomosugi: Diagnostic potential of tear and serum proteomic
patterns in mikulicz’s disease, 10th International Symposium on Sjogren’s Syndrome, (France, ‘09.10)，2009.

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0920

Division of Molecular Oncology and Virology

Faculty
Title(Additional Post)

Name

Field of Specialization

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

MOTOO Yoshiharu

Clinical Oncology,Gastroenterology,Cancer Cell Biology

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

MURAKAMI Manabu

Ｐａｔｈｏｇｅｎｉｃｉｔｙ ｏｆ flavivirus isolated from the field-collectedmosquitoes

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, hepatitis C virus, flavivirus, Japanese encephalitis
virus, virus replication, RhoGDI, Rho family, Eomes, epithelial/mesenchymal, nonstructural protein NS3, RNA synthesis,
transfection, persistent infection, RNAi

Outline of Research
Molecular analyses of virus replication, carcinogenesis and metastasis

Books
0920A003

Y.Motoo, T.Shimasaki, T.Minamoto: Gemcitabine changes the gene expression in human pancreatic cancer
cells :search for new therapeutic molecular targets, Pancreatology:from Bench to Bedside, 33-38, Springer, Berlin,
2009.

0920A005

Y.Motoo: Japanese Herbal Medicine in Western-style Modern Medical System, Botanical Medicine in Clinical
Practice, 105-111, CABI, UK, 2009.

Publications
Originals
0920B001(W.Mai), K.Kawakami, A.Shakoori, S.Kyo, K.Miyashita, K.Yokoi, M.Jin, T.Shimasaki, Y.Motoo, T.Minamoto:
Deregulated GSK3β Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse
Transcriptase and Telomerase, Clin. Cancer Res., 15：6810-6819, 2009.

0920B002(QM.Zhou), S.Wamg, H.Zhang, YY.Lu, XF.Wang, Y.Motoo, SB.Su: The combination of baicalin and baicaleinenhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells, Acta Pharmacol. Sin., 30:16481658, 2009.

0920B003

Y.Motoo, I.Arai, I.Hyodo, K.Tsutani: Current status of Kampo (Japanese herbal) medicines in Japanese clinicalpractice guidelines, Complement Ther Med., 17：147-154, 2009.

0920B004(S.Nukuzuma), M.Kaneoka, S.Sugiura, K.Nakamichi, C.Nukuzuma, I.Miyoshi, T.Takegami: Archetype JC virus
efficiently propagataes in kidney-derived cells stable expressing HIV-1 Tat, Microbiol. Immunol., 53:621-628,
2009.

0920B005(S.Nukuzuma), K.Nakamichi, C.Nukuzuma, T.Takegami: Inhibitory effect of serotonin antagonists on JC virus
propagation in a carrier culture of human neuroblastoma cells, Microbiol. Immunol., 53:496-501, 2009.

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Others
0920F005

Y.Ishigaki, T.Takata, N.Tomosugi, T.Takegami, H.Nakagawa: Introduction of OLS inNIBB, Japan Laser Therapy
Association., 8:15-18, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0920H001

T.Shimasaki, Y.Motoo: Molecular analysis on gemcitabine-treated pancreatic cancer cells., 2nd Japan-Taiwan Joint
Symposium on Medical Oncology, (Taipei, ‘09.12).

International Conference (Presentations)
0920I001

T.Shimasaki, Y.Ishigaki, N.Nakaya, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo:
Therapeutic effect of gemcitabine plus GSK3β inhibitor on pancreatic cancer: basic analysis for future clinical
trial, The International Pancreatic Research Forum 2009, (Tokyo, ‘09.03).

0920I002

T.Takegami, M.Murakami, K.Sato, T.Ota, Y.Ishigaki: Isolation of Japanese encephalitis virus (JEV) in Ishikawa,Japan and analysis of gene expression in JEV-infected cells bymicroarray, 43rd Joint Working Conference on Viral
Diseases、US-Japan Cooperative Medical Science Program、 Philadelphia, (Philadelphia, ‘09.07).

0920I003

Y.Motoo: Systematic review of Japanese clinical practice guidelines: how are Kampo medicines described?, The 8th
Meeting of the Consortium for Globalization of Chinese Medicine 2009, (Nottingham, ‘09.08).

0920I004

Y.Masaki, N.Kurose, H.Iwao, A.Nakajima, M.Yamamoto, H.Takahashi, M.Kawano, T.Saeki, S.Matsui, A.Azumi,
S.Nishiyama, Y.Zen, T.Sumida, M.Kojima, T.Yoshino, S.Nakamura, N.Tomosugi, T.Takegami, S.Sugai, H.Umehara:
Clinico-pathological analysis of 107 cases of IgG4+MOLPS (IgG4-positive multi-organ lymphoprolife-rative
syndrome), 10th International symposium on Sjögren’s syndrome, (BREST, ‘09.10).

－ 132 －

0930

Division of Dermatomycology (Novartis Pharma)

Faculty
Title

Name

Field of Specialization(Additional Post)

MOCHIZUKI Takashi Medical mycology，Dermatomycosis
ISHIZAKI Hiroshi

Medical mycology(Additional Post)

KAWASAKI Masako

Medical mycology(Additional Post)

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Publications
Originals
0930B001

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, Basavaraj M.Hemashettar: Successful Mating of a Human Isolateof Arthroderma simii with a Tester Strain of A. vanbreuseghemii, Jpn. J. Med. Mycol., 50：15-18, 2009.

0930B002

H.Ishizaki, M.Kawasaki, K.Anzawa, T.Mochizuki, Arunaloke Chakrabarti, Rataporn Ungpakorn, Haydee Torres
Guererro, Conchita Toriello, Robert Arenas: Mitochondrial DNA Analysis of Sporothrix schenckii in India Thailand,Brazil, Colombia, Guatemala and Mexico, Jpn. J. Med. Mycol., 50：19-26, 2009.

0930B003

K.Takeda, T.Ushigami, M.Nanbu, H.Tanabe, T.Mochizuki, A.Fukumura, Wun Bill Chen: Six Cases of Skin Damage
Related to Leakage from a Gastrostomy Catheter, Skin research., 8：31-35, 2009 (in Japanese) .

Reviews
0930C005

T.Mochizuki: Diagnosis of Cutaneous Fungal Infection, Jpn. J. Med. Mycol., 50：195-198, 2009 (in Japanese) .

0930C010

T.Mochizuki: Fungal infections and oter common skin diseases on the foot, 靴医学, 23：105111, 2009 (inJapanese) .

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Case Reports
0930D001(A.Arakawa), N.Kanazawa, S.Tanaka, M.Yonezawa, Y.Miyachi, T.Mochizuki: Genotyping of Trichophyton
tonsurans isolate from a Japanese boy reveals infection in the USA, Clin. Exp. Dermatol., 34：630-632, 2009.

0930D002(N.Umemoto), Ｔ.Demitsu, M.Kakurai, K.Sasaki, R..Azuma, E.Iida, K.Yoneda, M.Kawasaki, T.Mochizuki: Twocases of cutaneous phaeohyphomycosis due to Exophiala jeanselmei: diagnostic significance of direct microscopicalexamination of the purulent discharge, Clin. Exp. Dermatol., 34：351-353, 2009.

0930D003

J.Hatta, M.Yanagihara, M.Hasei, S.Abe, H.Tanabe, T.Mochizuki: Case of multiple cutaneous granular cell tumors,
J. Dermatol., 36：504-507, 2009.

0930D005(E.Asakawa), M.Fujihiro, T.Mochizuki: A Case of Granuloma Trichophyticum(Majocchi) Mimicking Leontiasis in
Clinical Appearance, Nishinihon j. dermatol., 71：160-163, 2009 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0930H001

T.Mochizuki: Application of molecular diagnosis of cutaneous fungal infections, The17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0930H002

M.Kawasaki, H.Tanabe, T.Mochizuki: Mycoses in Asia EP-03-3, Dematiaceous fungus infections in East Asia –molecular biological aspects－, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).

International Conference (Presentations)
0930I001

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, K.Kamei, M.Fujihiro, H.Shinoda: Molecularepidemiology of Trichophyton tonsurans isolated in Japan between 2006 to 2008, The 17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0930I002(M.Hata), K.Tatsuno, Y.Suzuki, K.Tomita, K. Sugaya, K.Anzawa, T.Mochizuki: Successful treatment of
sporotrichosis with voriconazole, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).

0930I003

H.Tanabe, T.Mochizuki, M.Kawasaki, T.Ushigami, N.Masayuki: Tinea barbae caused by Microsporum canis, The
17th Congress of the International Society for Human and Animal Mycology, (Tokyo, '09.05).

0930I004(M.Tochigi), T.Ochiai, C.Mekata, H.Nishiyama, K.Yamanaka, K.Anzawa, M.Kawasaki: Sporotrichosis of the face by
autoinoculation associated with tacrolimus treatment, The 17th Congress of The International Society for Humanand Animal Mycology, (Tokyo, '09.05).

0930I005

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, B.Hemashettar: Arthroderma vanbreuseghemii is a synonym ofA.simii, The 17th Congress of The International Society for Human and Animal Mycology, (Tokyo, '09.05).

0930I006

M.Kawasaki, K.Anzawa, T.Mochizuki, H.Ishizaki, B.Hemashettar:: Mating among three teleomorphs of

Trichophyton mentagrophytes, The 17th Congress of The International Society for Human and Animal Mycology,(Tokyo, '09.05).
0930I007J. Hatta, T.Hatta, S.Miyagawa, Y.Kitahara, T.Hirota, K.Anzawa, T.Mochizuki: Quantitative image analysis ofeffects of antimycotic agents on the hyphal growth in Trichophyton rubrum, The 17th Congress of The
International Society for Human and Animal Mycology, (Tokyo, '09.05).

0930I008

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, K.Kamei, Y.Takahashi, M.Fujihiro, H.Shinoda:
Molecular epidemiology of Japanese isolates of Trichophyton tonsurans by PCR-RFLP analysis of non-transcribedspacer region of ribosomal RNA gene, The 4th Joint Meeting of Japanese Dermatological Association and AustralianCollege of Dermatologist, (Tokyo, '09.07).

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0970

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

SASAKI Kazuyuki

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy(Additional Post)

KOJIMA Masami(Additional Post)

KAWAKAMI Yutaka

cataract, thyroid ocular

YAMASHIRO Yoko

ｃataract，electromagnetic wave induced ocular tissue changes，
epidemiology

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
0970B001(A.Arnarsson), KF.Damji, H.Sasaki, T.Sverrinsson, F.Jonasson: Pseudoexfoliation in the Reykjavik eye study:fiveyear incidence and changes in related ophthalmologic variables, Am. J. Ophthalmol., 148:291-297, 2009.

0970B002

K.Sasaki, Y.Yamashiro, M.Kojima, R.Honda, Y.Sakamoto, HM.Cheng, H.Sasaki: Assessment of pinguecuｌa andpterygium in the aging eye with ultraviolet fluorescence photography (UVFP) : Data analysis of eye disease survey
in Shanxi, China, Rehabilitation science : memoirs of the Tohoku Bunka Gakuen University Faculty of Medical
Science & Welfare, Department of rehabilitation., 5:31-40, 2009.

0970B003

M.Kojima, M.Hanazawa, Y.Yamashiro, H.Sasaki, S.Watanabe, M.Taki, Y.Suzuki, A.Hirata, Y.Kamimura, K.Sasaki:
Acute ocular injuries caudes by 60-GHz millimeter-wave exposure, Health Phys., 97:212-218, 2009.

0970B004

M.Fukuda, H.Sasaki: Measurement of AQCmax of five diffeｒnt ophthalmic solution and discussion of its new
application, J Ocul Pharmacol Ther, 25:351-355, 2009.

0970B005

H.Kawada, M.Kojima, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD on UV-B-Induced cataracts in
rats, Jpn. J. Ophthalmol., 53:531-535, 2009.

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0970B006

H.Sasaki: Obsevational cohort study : The Reykjavik eye study, Journal of the eye., 26:17-24, 2009 (in Japanese) .

0970B007

M.Fukuda, H.Sasaki: Cytotoxic effects of new quinolone antibiotic ophthalmic solutions nad nonsteroidal antiinflammatory ophthalmic solutions on cultured rabbit corneal cell line, Journal of the eye., 26:399-403, 2009 (inJapanese) .

0970B008

M.Fukuda, H.Sasaki: Cytotocic effect of ofluoxacin ophthalmic solutions and timolol maleate ophthalmic solutions
on cultured rabbit corneal cell line and ocular pharmacokinetics of ophthalmic solutions in rabbits, Journal of theeye., 26:977-981, 2009 (in Japanese) .

Case Reports
0970D001

S.Inagaki, K.Kitagawa, K.Nagai, K.Hagiwara, H.Sasaki: An infant case of acute purulent dacryoadenitis due to
MRSA, Journal of the eye., 26:1405-1408, 2009 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0970I001

J.Qu, H.Sasaki, Y.Sakamoto, E.Shibuya, K.Sasaki: Influence of watercleft on ocular higher order aberrations, The
Association for Research in Vision and Ophthalmology, (Florida, '09.05).

0970I002

M.Fukuda, N.Takahashi, M.Yoshikawa, M.Kojima, Y.Sakamoto, H.Sasaki: Monitoring real time recovery from
corneal disorder with a corneal resistance device in vivo, The Association for Research in Vision andOphthalmology, (Florida, '09.05).

0970I003

M.Kojima, T.Sakai, Y.Yamashiro, T.Matsuda, S.Watanabe, H.Shirai, K.Sasaki, H.Sasaki: Characteristics of oculartemperature rise under exposure to frequency (18-40 GHz), BIOEM, (Davos, '09.06).

0970I004(T.Sakai), M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki, S.Watanabe, K.Sato: Development of measurement system
for MMW exposure to a rabbit, BIOEM, (Davos, '09.06).

0970I005(T.Taguchi), H.Sitou, S.Kurogi, Y.Suzuki, M.Kojima, T.Sakai, S.Watanabe, H.Sasaki, M.Taki: Visualization of
Temperature distribution change due to millimeter-wave exposure with micro-encapsulated thermo-chromic liquid
crystal, BIOEM, (Davos, '09.06).

0970I006

K.Kitagawa, M.Higuchi, H.Tsuchida, H.Sasaki, N.Tomosugi: Diagnostic potential of tear and serum proteomic
patterns in mikulicz's disease, 10th International Symposium on Sjogren's Syndrome, (France, '09.10)，2009.

0970I007

H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, Y.Yamashiro, K.Sasaki: UV exposure to the Eye as a function of solar
altitude, American Academy of ophtometry, (Florida, '09.11).

0970I008

N.Hatsusaka, Y.Sakamoto, E.Shibuya, N.Mita, H.Sasaki: Influence of nuclear opacity on intraocular higher-orderaberrations, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

0970I009

M.Kojima, Y.Yamashiro, T.Sakai, Y.Suzuki, K.Sasaki, H.Sasaki: Heat cataract by millimeter wave band exposureand thermal transport of aqueous humor, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'09.12).

0970I010

H.Sasaki, T.Abe, S.Furui, Y.Sakamoto, S.Suzuki, H.Koutake, K.Terasaki, T.Ishitake, N.Hayabuchi: The effects ofionization radiation exposure on crystalline lenses of interventional radiologist, US-Japan Cooperative Cataract
Research Group Meeting, (Hawaii, '09.12).

0970I011

K.Nagai, H.Sasaki, R.Honda, M.Kojima, K.Sasaki, F.Jonasson, M.Ono: Lens thickness by three main types ofcataract -Reykjavik Eye Study:2008-, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

0970I012

M.Kojima, Y.Ishiba, Y.Iwai, K.Sasaki, H.Sasaki: Study of reflected Ight form the back side of lenses (Glasses or
Sunglasses), as a Penetration route into the Eye, US-Japan Cooperative Cataract Research Group Meeting,(Hawaii, '09.12).

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0970I013

Y.Yamashiro, M.Kojima, A.Hirata, T.Sakai, S.Watanabe, M.Taki, Y.Sakamoto, K.Sasaki, H.Sasaki: Comparison oftemperature elevation in ocular tissue by 18-40 GHz radio-frequency exposure, US-Japan Cooperative Cataract
Research Group Meeting, (Hawaii, '09.12).

0970I014

E.Shibuya, Y.Sakamoto, N.Yamamoto, H.Sasaki: Influence of age and axial length on intraocular higher orderaberrations, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii, '09.12).

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9050

Center for FDD-MB

Faculty
Title

Name

Field of Specialization

TAKABAYASHI Haruo fetal medicine, DNA medicine
YUDITIYA Purwosunu

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman’s health, DNAarray,Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother’s health
2. development of fetal DNA diagnosis from maternal blood(FDD-MB)
3. development of single cell technology

Presentations at Conference
International Conference (Presentations)
9050I001

H.Takabayashi, P.Yuditiya, M.Kita, K.Ikawa, A.Sekisawa, H.Chiba, M.Kitagawa: FDD-MB 2.0 System and Future,
CNAPS-Ⅳ Hong Kong, (Hong Kong, '09.11).

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Himi Municipal Hospital

9100

Himi Municipal Hospital.

Faculty
Title

Name

Field of Specialization

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery.

IZUMI Youichi

Hypertension，Endocrinology

SAKAMOTO Shigeru

Cardiovascular Surgery

KUZAWA Yutaka

Cardio Vascular Surgery

NAKASHIMA Aiko

Radioloy

NAKATANI Yusuke

Ophthalmology

KURAUCHI Manabu

Cerebro vascular disease

MATSUI Toshiaki

Oral & Maxilofacial Surgery

URATA Kazuhiko

Obstetrics and gynecology

SAITO Atsushi

Nephrology

TAKATA Hideo

Orthopaedic Surgery

WATANABE Kimimasa Orthopaedic Surgery
YAMASHITA Naohiro Circulatory organs internal medicine
MUKAI Hirokado

Oncology Surgery

HASEGAWA Masayuki regional medicine
NAKANAMI Aki

Orthopaedic Surgery

KUSABA Eizo

neurosurgery

Publications
Originals
9100B001

Shin-ichiro Yoshitani, Shigeki Takashima: Efficacy of postoperative UFT (Tegafur /Uracil) plus PSK therapies inelderly patients with resected colorectal cancer, Cancer Biother. Radiopharm., 24:35-39, 2009.

Case Reports
9100D001

M.Fukura, A.Saito, K.Ishigami, K.Konishi, M.Hasegawa, JL.Wu, H.Kawahara, T.Kanda, T.Kigoshi, N.Takekoshi:
Suicides in aged patients; Case reports and review of the literature, J. Kanazawa. Med. Univ., 34:14-16, 2009.

Presentations at Conference
International Conference (Presentations)
9100I001

H.Yokoyama, A.Saito, Y.Saito, I.Ishikawa: Intact parathyroid hormone levels at 3 hours of loading test reflect theeffects of Cinacalcet in both hemodialysis and renal transplanted patients., Renal Week 2009 ASN`s 42nd Annual
Meeting ＆ Scientific Exposition, (SanDiego, '09.10).

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Kanazawa Medical University
Research Activities and Publications 2009
Published December, 2010
Issuer: Syogo Katsuda
Editer: Takayuki Nojima
Publishing office: Kanazawa Medical University Publication office
1-1 Daigaku,Uchinada-machi,Kahoku-gun,Ishikawa-ken,Japan,920-0293
Tel +81 76 286 2211(Representative)

Printing office: TANAKA&SHOBUNDO GRAPHIC ART Co.LTD.

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