SAFETY DATA SHEETSDS No.5010-0207

Revised date

April 2, 2024

1/4 page

1. PRODUCT AND COMPANY IDENTIFICATIONPRODUCT NAME
： InertSep K-solute Plus
NAME OF SUPPLIER： GL Sciences Inc.
ADDRESS： 22-1 Nishishinjuku 6-chome Shinjuku-ku Tokyo 163-1130, JapanCHARGE SECTION： International Sales Section
TELEPHONE No.
： +81-3-5323-6620
FACSIMILE No.
： +81-3-5323-6621
PRODUCT No.
： 5010-68250, 5010-68251, 5010-68252, 5010-68253, 5010-68254, 5010-69200,
5010SDS No.
： 5010-0207
Research use only.
2. HAZARDS IDENTIFICATIONGHS CLASSIFICATIONHAZARDS SYMBOL： Carcinogenicity： Category 1ASpecific target organ toxicity (Repeated exposure)： Category 1(Respiratory organs)：

SIGNAL WORD
： Danger
HAZARD STATEMENTS：
H350
May cause cancer
H372
Cause damage to organs through prolonged or repeated exposure
PRECAUTIONARY STATEMENTS ：P201
Obtain special instructuions before use.
P202
Do not handle until all safety precautions have been read and understood.
P260
Do not breathing dust/fume/gas/mist/vapours/spray.
P264
Wash hands thoroughly after handling.
P270
Do not eat, drink or smoke when using this product.
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313
IF exposed or concerned: Get medical attention.
P314
Get medical attention if you feel unwell.
P405
Store locked up.
P501
Dispose of contents/container in accordance with all applicable regulations.
3. COMPOSITION/INFORMATION ON INGREDIENTSSUBSTANCE/MIXTUER： Substance
CHEMICAL NAME
： Diatomaceous earth
SYNONYMS： Kieselguhr, soda ash flux-calcined
CHEMICAL FORMULA： --MOLECULAR WEIGHT： --CONTENT： --CAS RN： 68855-54-9
TSCA INVENTRY： Listed
EINECS No.
： 272-489-0
EC INDEX No.
： Not established
4. FIRST AID MEASURES
GENERAL ADVICEINHALATION： Wash off immediately with soap and plenty of water. In the case of respirable
dust and/or fumes, use self-contained breathing apparatus and dust impervious
protective suit. Use personal protective equipment.
： Move victim to fresh air and gargle. If breathing is difficult, give oxygen.
If irritation persists, consult a physician.

PRODUCT NAME ： InertSep K-solute PlusSDS No.5010-0207
SKIN CONTACTEYE CONTACTINGESTION

Revised dateApril 2, 2024

2/4 page： Remove contaminated clothes and shoes, rinse skin with plenty of water orshower. Use soap to help assure removal. If irritation persists, consult aphysician.
： Remove any contact lenses at once. Flush eyes well with flooding large amountsof running water for at least 15 minutes. Assure adequate flushing by separating
the eyelids with sterile fingers. If irritation persists, consult a physician.
： Rinse mouth, give plenty of water to vomit. Never give anything by mouth to an
unconscious person. Consult a physician.

5. FIRE FIGHTING MEASURES
EXTINGUISHING MEDIA
FIRE & EXPLOSION HAZARDS： Carbon dioxide, dry chemical powder, foam, water spray： CO2, CO are included in a flue gas. Use cylinder-type air respiratory apparatus
at the fire extinguishing in the room.
Pay attention to shatter-resistant this product.
SPECIAL PROTECTIVE EQUIPMENT FOR FIRE FIGHTERS： Fireman should wear normal protective equipment (full bunker gear) andpositive-pressure self-contained breathing apparatus.

6. ACCIDENTAL RELEASE MEASURESPERSONAL PRECAUTIONS： Remove ignition sources and ventilate the area. In case of insufficient ventilation,wear suitable respiratory equipment. Avoid raising dust and avoid contact withskin and eyes.
ENVIRONMENTAL PRECAUTIONS： Prevent spills from entering sewers, watercourses or low areas.
Comply with local disposal regulations.
METHODS FOR CLEANING UP： Do not touch spilled material without suitable protection. After material iscompletely picked up, wash the spill site with soap and water and ventilate thearea. Pull all wastes in a plastic bag for disposal and seal it tightly. Remove,clean, or dispose contaminated clothing.
7. HANDLING AND STORAGE
HANDLING
STORAGEINCOMPATIBLE PRODUCTS： Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeatedexposure. Handle this product with appropriate protective equipments.
： Store away from sunlight in a cool well-ventilated dry place.
Keep container tightly closed.
： Oxidizers and acids

8. EXPOSURE CONTROL/PERSONAL PROTECTION
ENGINEERING MEASURES： Use exhaust ventilation to keep airborne concentrations below exposure limits.
Use adequate ventilation.
VENTILATION： Local Exhaust ; Necessary, Mechanical(General) ; Recommended
CONTROL PARAMETERS
ACGIH TLV
： Not established
OSHA PEL： Not established
NIOSH REL
： Not establishedPERSONAL PROTECTIONRESPIRATORY PROTECTION ： Half or full face piece respirator, self-contained breathing apparatus, supplied
air respirator, etc. Use respirators approved under appropriate government
standards and follow all regulations.
HAND PROTECTION： Safety gloves
EYE PROTECTION： Safety glasses(goggles)
SKIN PROTECTION： Protective clothing
9. PHYSICAL AND CHEMICAL PROPERTIESAPPEARANCE： White to light brown or light gray powder
PHYSICAL STATE： SolidODOR： Odorless
MELTING POINT / FREEZING POINT： 1,400 °C
BOILING POINT OR INITIAL BOILING POINT AND BOILING RANGE： No data available
FLAMMABILITY： No data available
LOWER AND UPPER EXPLOSION LIMIT / FLAMMABILITY LIMIT： No data available

PRODUCT NAME ： InertSep K-solute PlusSDS No.5010-0207

Revised date

April 2, 2024

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FLASH POINT： No data available
AUTO-IGNITION TEMPERATURE ： No data available
DECOMPOSITION TEMPERATURE： No data available
pH： No data available
KINEMATIC VISCOSITY： Not applicable
SOLUBILITY INWater： Insoluble
Organic solvent： Insoluble
PARTITION COEFFICIENT
n-octanol/water (log value)： No data available
VAPOUR PRESSURE： No data available
DENSITY AND/OR RELATIVE DENSITY： No data available
RELATIVE VAPOUR DENSITY： Not applicable
PARTICLE CHARACTERISTICS ： No data available
10. STABILITY AND REACTIVITY
REACTIVITYCHEMICAL STABILITY： Stable under recommended using and storage conditions.
： Stable under recommended storage and using conditions.
May be altered by light.
CONDITION TO AVOID： Sunlight, heat, moisture, dust diffusion.
INCOMPATIBLE MATERIALS： Strong oxidizing agents, strong acids.
HAZARDOUS DECOMPOSITION PRODUCTS： Hazardous fumes, etc.

11. TOXICOLOGICAL INFORMATIONACUTE TOXICITY： No data available
SKIN CORROSION/IRRITATION ： No data available
EYE DAMAGE/EYE IRRITATION ： Painful when it enters the eye.
SENSITIZATION： No data available
GERM CELL MUTAGENICITY： No data available
CARCINOGENICITY： Crystalline silica is classified as Group 1 by IARC (IARC 100C (2012)),
as K by NTP (NTP RoC (14th, 2016)), as Group 1 by the Japan Society
for Occupational Health (Recommendation on Tolerable Concentrations(2016)), and as Category 1A. This substance is classified as class 1A b
ecause it contains more than the cutoff value (0.1%) of carcinogenic class 1 crystalline silica, which is class 1A.
There is no information on the carcinogenicity of diatomaceous earth in humans,
and in experimental animals, no tumors were observed in a lifetime exposure
study in rats by oral (mixed-food) route at a dose of 20 mg/animal and in miceby subcutaneous injection (dose frequency not stated) at 20 mg/animal (IARC68 (1997)). (IARC 68 (1997)). On the other hand, in a study in which mice wereinjected intraperitoneally at 20 mg/animal (number of doses not stated),
lymphosarcoma was reported to have occurred in 6/17 mice, showing asignificant increase compared to the control group (1/20 mice). However, noneof the study reports stated the amount of crystalline silica in the test substance(diatomaceous earth), so the presence or absence of crystalline silica is notknown (IARC 68 (1997)).
REPRODUCTIVE TOXICITY： No data available
SPECIFIC TARGET ORGAN TOXICITY -single exposure： No data available

PRODUCT NAME ： InertSep K-solute PlusSDS No.5010-0207

Revised dateApril 2, 2024

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SPECIFIC TARGET ORGAN TOXICITY -repeated exposure： As for humans, there have been reports of dust lung disease in workers exposed
to diatomaceous earth, but it has not been determined that the dust lung disease
was caused by diatomaceous earth because exposure to other quartz dust isunknown, cristobalite is produced when diatomaceous earth is calcined, andcrystalline silica is present in diatomaceous earth (DFGOT vol. 2 (1991)), andonly mild silicosis has been reported in workers exposed to diatomaceous earth
exposed to unburned dust (ACGIH (7th, 2001)). Studies of workers exposed tocrude diatomaceous earth or natural dust for 20 to 25 years have also shownthat lung fibrosis rarely occurs, and if it does, it is symptomatic and not clearly
disabling. It has been reported that natural diatomaceous earth itself is weakly
fibrogenic or non-fibrogenic and that lung fibrosis may be due to crystalline silicaor lung overload (ACGIH (7th, 2001)).
In experimental animals, guinea pigs were exposed to 100 mg/m3 ofdiatomaceous earth as amorphous silica and 150 mg/m3 of cristobalite as
crystalline silica by inhalation for 2 years. Diatomaceous earth, an amorphoussilica, showed fibrosis at 24 months, but no serious effects were observed(ACGIH (7th, 2001)). In a study of guinea pigs exposed by inhalation to 60
mg/m3 of unfired diatomaceous earth for 37-50 weeks, macrophage infiltration,
thickening of the alveolar septum due to accumulation of numerous polynuclear
cells containing dust particles, and alveolar epithelialization were observed, butno lung fibrosis and a very slight increase in the amount of microvilli fibers wasobserved. However, there was no lung fibrosis and no significant increase incollagen fibers (ACGIH (7th, 2001)).
ASPIRATION TOXICITY： No data available
12. ECOLOGICAL INFORMATIONECOTOXICITY： No data available
BIODEGRADABILITY： No data available
BIOACCUMULATION POTENTIAL ： No data available
MOBILITY IN SOIL
： No data available
OTHER ADVERSE EFFECTS： Not listed in Montreal Protocol list.
13. DISPOSAL INFORMATION
Dispose in a hazardous-waste site in accordance with all applicable regulations. Any disposal practice must be incompliance with country, local, state, and federal laws and regulations (contact country, local or state environment
agency for specific rules).
14. TRANSPORT INFORMATION
IATA： Not dangerous goods
ADR/RID： Not dangerous goods
DOT(Department of Transportation)： Not dangerous goods
MARINE POLLUTANT： Not classified
15. REGULATORY INFORMATIONFor classification and labeling of chemicals in accordance with the applicable rules and regulations in the EU or eachcountry, refer to GHS classification of this product (See Section 2).
US REGULATION ：OSHA HCS 2012/29 CFR 1910.1200
EU REGULATION ：CLP Regulation ((EC) No. 1272/2008)
16. OTHER INFORMATIONNOTICE:The information contained in the SDS description is applicable exclusively to the chemical substance identified herein
and for its intended use as an analytical reference standard or reagent and to the unit quantity intended for that purpose.
The information does not relate to, and may not be appropriate for, any application or larger quantity of the substancedescribed. Our products are intended for the use by individuals possessing sufficient technical skill and qualification
on use the material potential hazardous chemical. Accordingly, no representation or warranty, express or implied, withrespect to merchantability and fitness for a particular purpose is made with respect to the information contained herein.
Attention:
This product in terms of chemical identity and the unit amount provide is intended for use in chemical analysis and notfor human consumption, nor any other purpose.