Program
Day 1: November 1 (Wed)9:55-10:00

Opening Remarks

10:00-10:15

Oral Presentations

1O-01

Chair:

Control of Nucleic Acid Phase Separation usingAptamers

Toshihiro Ihara

Samuel Hauf1, Yohei Yokobayashi*1

Kumamoto University

1Nucleic Acid Chemistry and Engineering Unit, Okinawa Institute ofScience and Technology

1O-02

10:15-10:30

Chemical targeting of i-motif DNAs for cancer
theranostic applications
Sinjan Das1, Shuntaro Takahashi1, Tatsuya Ohyama1,
Sudipta Bhowmik2,3, Naoki Sugimoto*1,4
1Frontier Institute for Biomolecular Engineering Research (FIBER),

Konan University, 2University of Calcutta, 3MGMARI, Sri Balaji
Vidyapeeth, 4Graduate School of Frontiers of Innovative Research in
Science and Technology (FIRST), Konan University

1O-03

10:30-10:45

Heme Regulation by Mitochondrial-Generated
lncRNAs via G-Quadruplex Structures
Vinodh J. Sahayasheela1,2, Ryohei Noizumi1, Amit R.
Reddi3, Hiroshi Sugiyama*1,2
1Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto

University, 2Department of Chemistry, Graduate School of Science,
Kyoto University, 3School of Chemistry and Biochemistry, Georgia
Institute of Technology
10:45-11:00

Oral Presentations

1O-04

Chair:Takehiko Wada

In-cell NMR study of the structure and interaction ofan RNA aptamer targeting HIV-1 Tat within living
human cells
Omar Eladl1,2, Yudai Yamaoki1,2, Keiko Kondo1, Takashi
Nagata1,2, Masato Katahira*1,2Tohoku University

1Institute of Advanced Energy, and 2Graduate School of Energy

Science, Kyoto University

1O-05

11:00-11:15

Expanding ribozyme nanostructures throughassembly of a cyclic trimer of modular ribozymes
Yoshiya Ikawa*1,2, Mst. Ayesha Siddika1, Kumi Hidaka3,Hiroshi Sugiyama4, Masayuki Endo4,5, Shigeyoshi
Matsumura1,2
1Graduate School of Innovative Life Science, University of Toyama,
2Graduate School of Science and Engineering, University of Toyama,
3Graduate School of Science, Kyoto University, 4Institute forIntegrated Cell-Material Sciences, Kyoto University, 5Organization for
Research and Development of Innovative Science and Technology,
Kansai University

1O-06

11:15-11:30

Human genome writing for understanding
functionality of noncoding regions and diseasecausing mutations
Hikaru Kurasawa1, Tomoyuki Ohno2, Yasunori Aizawa*1,2
1Kanagawa Institute of Industrial Science and Technology, 2School ofLife Science and Technology, Tokyo Institute of Technology
11:30-11:45

Break11:45-12:25

Invited Lecture 1IL-01

Non canonical tetra helices: find the differences!
Claudia Sissi, Michele Ghezzo

Chair:

Department of Pharmaceutical and Pharmacological Sciences,
University of Padova

Naoki Sugimoto
Konan University
12:25-13:35

Lunch Break

13:35-15:10

Poster Presentations (1P-n)

15:10-15:25

Oral Presentations

1O-07

Chair:

Kiyohiko Kawai

Development of PureCap Method Toward Synthesisof Fully Capped Messenger RNA by In Vitro
Transcription
Masahito Inagaki1, Naoko Abe1, Yuko Nakashima1,2, Li
Zhenmin1, Susit Acharyya1, Kazuya Ogawa1, Daisuke
Kawaguchi1, Haruka Hiraoka1, Mizuki Tada1, Zheyu Meng1,Tatsuma Ishida1, Pingxue Lyu1, Fumitaka Hashiya2,Yasuaki Kimura1, Satoshi Uchida3,4, Hiroshi Abe*1,5,6

Tokyo Institute ofTechnology

1Graduate School of Sciences, Nagoya University, 2Research centerfor Materials Science, Nagoya University, 3Tokyo Medical and Dental
University, Medical Research Institute, 4Innovation Center of
NanoMedicine (iCONM), 5JST-CREST, 6Institute for Glyco-core
Research (iGCORE)
15:25-15:40

1O-08

Abasic site generation in nucleic acids by photocatalytic reaction
Yuuhei Yamano1, Kazumitsu Onizuka*1,2, Altan Okan1,Madoka Sasaki1,2, Ahmed Mostafa Abdelhady1,Fumi Nagatsugi*1,2
1Institute of Multidisciplinary Research for Advanced Materials,Tohoku University, 2Graduate School of Science, Tohoku University
15:40-15:55

1O-09

Virus detection and on-site visualization of infected
spot by sequential enzymatic reaction between
antibody-enzyme complex and Aptamer-DNAzyme
Daimei Miura1, Wakana Hayashi1, Kensuke Hirano2,Kaori Tsukakoshi1, Hidehumi Kakizoe3, Satomi Asai3,4,
Wakako Tsugawa1,2, Koji Sode5,6, Kazunori Ikebukuro1,Ryutaro Asano*1,6
1Department of Biotechnology and Life Science, Graduate School ofEngineering, Tokyo University of Agriculture and Technology,
2Department of Industrial Technology and Innovation, Graduate
School of Engineering, Tokyo University of Agriculture andTechnology, 3Department of Laboratory Medicine, Tokai University
School of Medicine, 4Division of Infection Control, Tokai University
Hospital, 5Joint Department of Biomedical Engineering, University ofNorth Caroline at Chapel Hill and North Carolina State University,
6Institute of Global Innovation Research, Tokyo University ofAgriculture and Technology
15:55-16:10

Oral Presentations

1O-10

Chair:

16:10-16:25

Advances in DNA and RNA Polymer Hybrids andGels

Hisae TateishiKarimata

Jaepil Jeong1,2, Grzegorz Szczepaniak1,3, KrzysztofMatyjaszewski1, Subha R. Das*1,2

Konan University

1

Department of Chemistry and 2Center for Nucleic Acids Science &Technology, Carnegie Mellon University

1O-11

DNA-commanded Morphological Transformation ofLipid Bilayer Chaperoned by PNA-cationic
Copolymer Conjugates
Wancheng Zhang, Naohiko Shimada, Atsushi Maruyama*
Department of Life Science and Technology, Tokyo Institute ofTechnology

16:25-16:40

Break

16:40-17:20

Invited Lecture 2IL-02

Michal Hocek1,2

Chair:

17:20-17:35

From Functionalized to Hypermodified Nucleic Acids

Hisao Saneyoshi

1Institute of Organic Chemistry and Biochemistry, Czech Academy ofUniversity of MiyazakiSciences, 2Dept. of Organic Chemistry, Faculty of Science, CharlesUniversity

Oral Presentations

1O-12

Chair:Kohji Seio

Taiki Tsurusaki, Kazuki Sato, Takeshi Wada*

Tokyo Institute ofTechnology

17:35-17:50

Internucleotidic bond formation using
H-phosphonamidate derivatives andacidic activators
Department of Medicinal and Life Sciences, Faculty of
Pharmaceutical Sciences, Tokyo University of Science

1O-13

Amino acid-Nucleic acid Hybrids (ANHs) forCatalysis and Aptamer Applications
Soyoung Park
Immunology Frontier Research Center (IFReC), Osaka University

17:50-18:05

1O-14

Enzymatic synthesis of several 2′-O-alkyl modified
oligonucleotides with wide range of hydrophobicity
Kenta Ishida1,2, Hidekazu Hoshino1, Satoshi Obika1,2,3,Yuuya Kasahara*1,2
1National Institutes of Biomedical Innovation, Health and Nutrition,
2Graduate School of Pharmaceutical Sciences, Osaka University,
3Institute for Open and Transdisciplinary Research Initiatives, OsakaUniversity
18:05-18:20

Oral Presentations

1O-15

Chair:

Predicting Molecular Interactions by Graph
Convolutional Neural Networks with Global Features
Kaito Fukui*1, Qingwen Chen2, Hiroaki Santo1,
Fumio Okura1, Takeshi Yamada3, Yasuyuki Matsushita1,Kazuhiko Nakatani2

Takeshi Wada
Tokyo University ofScience

1Graduate School of Information Science and Technology, Osaka

University, 2SANKEN (The Institute of Scientific and IndustrialResearch), Osaka University, 3Nucleotide and Peptide Drug
Discovery Center, Tokyo Medical and Dental University
18:20-18:35

1O-16Sensing unit tethered oligodeoxynucleotides for themultiplex biomolecular analysis
Tatsuya Nishihara, Yuto Motohashi, Reoto Mio, Masato
Sugawara, Shuhei Moritani, Kazuhito Tanabe*College of Science and Engineering, Aoyama Gakuin University

18:35-18:50

1O-17

Selective Recognition of 2-Hydroxy2’-Deoxyadenosine in DNA Using Pseudo-dC
Derivatives
Ryo Miyahara, Yosuke Taniguchi*Graduate School of Pharmaceutical Sciences, Kyushu University

Day 2: November 2 (Thu)
10:00-10:15

Oral Presentations

2O-01

Chair:Yohei
Yokobayashi

Yuyang Wu1, Chelsea Brown2, Zeki Duman3, Tod Kippin2,Kevin Plaxco*1

The Okinawa Instituteof Science andTechnology

10:15-10:30

Adaptation of tryptophan aptamer into anelectrochemical aptamer-based sensor for use intryptophan metabolism studies in the rat

1Department of Chemistry and Biochemistry, University of California

Santa Barbara, 2Department of Psychological and Brain Sciences,
University of California Santa Barbara, Santa Barbara, 3Department
of Electrical and Computer Engineering, University of California Santa
Barbara2O-02

Exploration of DNA binding proteins for assemblingcovalently bound DNA-protein complexes and theapplication for biosensing system
Erika Komiya1, Shouhei Takamatsu1, Daimei Miura1,
Kaori Tsukakoshi1, Wakako Tsugawa1,2, Koji Sode3,
Kazunori Ikebukuro1, Ryutaro Asano*1,4
1Department of Biotechnology and Life Science, Graduate School ofEngineering, Tokyo University of Agriculture and Technology,
2Department of Industrial Technology and Innovation, Graduate
School of Engineering, Tokyo University of Agriculture andTechnology, 3Joint Department of Biomedical Engineering, Universityof North Carolina at Chapel Hill and North Carolina State University,
4Institute of Global Innovation Research, Tokyo University ofAgriculture and Technology
10:30-10:45

2O-03

From two strands to four - the interaction ofruthenium polypyridyl complexes with nucleic acidstructures
James P. Hall*1, Ahmad Abdullrahman1,Tayler David Prieto Otoya2, Kane McQuaid2,
David J. Cardin2, Christine J Cardin2
1School of Pharmacy, University of Reading, 2Department ofChemistry, University of Reading
10:45-11:00

Daisuke Miyoshi

G-quadruplex ligands, G-quadruplex structure andNONO protein regulate ABCA1 expression inmacrophages

Konan UniversityChao-Da Xiao*

Oral Presentations

2O-04

Chair:

State Key Laboratory of Functions and Applications of Medicinal
Plants, Guizhou Medical University
11:00-11:15

2O-05

New discovery of Z-form DNA-RNA hybrid structure
in vitro and in living cells and its function in DNA
replication
Shiyu Wang, Yan Xu*
Division of Chemistry, Department of Medical Sciences, Faculty ofMedicine, University of Miyazaki

11:15-11:30

Break

11:30-12:10

Invited Lecture 3
Chair:

Masato Katahira
Kyoto University

IL-03

Biological functions of G-quadruplexes in regulationof DNA replication
Hisao Masai
Department of Basic Medical Sciences, Tokyo Metropolitan Instituteof Medical Science12:10-13:35

Lunch Break

13:35-15:10

Poster Presentations (2P-n)

15:10-15:25

Break

15:25-16:25

JASNAC General Meeting

16:25-16:55

Special Lecture 1

Luncheon Seminar Sponsored by SynCrest

SL-01

Chair:

Mitsuhiko Shionoya

Akimitsu Okamoto

Department of Chemistry, Graduate School of Science, The Universityof Tokyo

The University ofTokyo
16:55-17:25

Special Lecture 2
Chair:

Kazuhiko Nakatani
Osaka University

New Developments in Nucleic Acid Chemistry
Based on Metal-Mediated Nucleobase Pairing

SL-02

Molecular recognition and functionalization ofnucleic acid and protein assemblies
Takashi Morii
Institute of Advanced Energy, Kyoto University

17:55-19:00

Transit

19:00-21:00

Exchange Meeting at MRT micc Diamond Hall

Day 3: November 3 (Fri)10:00-10:40

Invited Lecture 4IL-04

Chair:

Synthetic RNA and RNP technologies to manipulate
cells

Fumi Nagatsugi

Hirohide Saito

Tohoku University

Center for iPS cells Research and Application, Kyoto University

10:40-10:55

Break

10:55-11:10

Oral Presentations

3O-01

Chair:

E. Coli can eat DNA and RNA as food – Nucleic acids
are significant nutrition
LiLi Huang1, Jing Hao1, Xinmei Du1, Jingyun Zhuang1,Ran An1,2, Xingguo Liang*1,2

Atsushi Maruyama
Tokyo Institute ofTechnology

1College of Food Science and Engineering, Ocean University ofChina, 2Laboratory for Marine Drugs and Bioproducts, Pilot National
Laboratory for Marine Science and Technology (Qingdao)
11:10-11:25

3O-02

Novel Design Strategy of DNA-Artificial Nucleic Acid
Chimera (CANA) Toward Enhancement of RNase H
Mediated Target RNA Cleavage Activities:
Application for COVID-19 Therapeutics IV
Takehiko Wada*1, Kazutoshi Fujita1, Yuto Horiuchi1,Nozomu Ishiwata1, Masahito Inagaki1,3, Hironori Hayashi2,Yasuyuki Araki1, Masaki Nishijima1, Eiichi Kodama2
1Institute of Multidisciplinary Research for Advanced Materials(MRAM), Tohoku University, 2International Research Institute ofDisaster Science (IRDeS), Tohoku University, 3Grad. School Science,Nagoya University
11:25-11:40

3O-03

Targeting the G-quadruplex at the Human VascularEndothelial Growth Factor Internal Ribosomal Entry
Site: Repression of Translation by a Selective Small
LigandXiang-Chun Sheng*State Key Laboratory of Functions and Applications of Medicinal
Plants, Guizhou Medical University

11:40-11:55

Oral Presentations

3O-04

Chair:

Interaction of cyclic ferrocenylnaphthalene diimdiewith G-quadruplex RNA of SARS-CoV-2

Yoshiya Ikawa

Shigeori Takenaka*, Shinobu Sato, Shuma Kaneyoshi

University of Toyama

Department of Applied Chemistry, Kyushu Institute of Technology

11:55-12:10

3O-05

Blinking as an Additional Fluorescence-Based
Readout Parameter: Blinking controlled by ElectronTransfer through DNA
Shuya Fan1, Tadao Takada2, Atsushi Maruyama3,
Mamoru Fujitsuka1, Kiyohiko Kawai*3
1SANKEN, Osaka University, 2Graduate School of Engineering,

University of Hyogo, 3Department of Life Science and Technology,
Tokyo Institute of Technology
12:10-12:25

3O-06

Specific binding of cationic oligodiaminogalactoses
to duplex RNA without binding to duplex DNA:Thermodynamic study
Hidetaka Torigoe*1, Sumire Nakayama1, Tomomi Shiraishi2,Kazuki Sato2, Rintaro Iwata-Hara3, Takeshi Wada2
1Department of Applied Chemistry, Faculty of Science, Tokyo

University of Science, 2Department of Medicinal and Life Sciences,
Faculty of Pharmaceutical Sciences, Tokyo University of Science,
3Department of Neurology and Neurological Science, Graduate
School of Medical and Dental Sciences, Tokyo Medical and Dental
University
12:25-

Closing Remarks