Prof. Nicola X. West

略歴
Professor Nicola X. West is a graduate of the University of Wales College of Medicine（Cardiff）. After attaining her fellowship from the Royal College of Surgeonsof England, she was awarded her PhD from the University of Wales（Cardiff）in
1995, on dentine hypersensitivity and tooth surface loss. She gained her chair in
Periodontology at Bristol Dental School, where she conducts research, leading theClinical Trials Unit and attracting substantial industrial funding. She is also an
Honorary Consultant in Restorative Dentistry. She has established a reputation foraesthetic treatment of complex restorative cases involving periodontal, implantand prosthodontic treatment. She lectures regularly in the national and international forum. She is the Secretary General of the European Federation of Periodontology and President elect of the British Society of Periodontology. She also runs athriving specialist practice in Bristol, UK.

Efficacy of an aluminium lactate/potassium nitrate/hydroxyapatite
toothpaste compared to a potassium nitrate toothpaste forthe treatment of dentine hypersensitivity
Periodontology, Clinical Trials Unit, Bristol Dental Hospital & School, University of Bristol
Nicola X. WestBackground
Dentine hypersensitivity（DH）is a common oral pain condition, arising when dentine is exposed by tooth wear or gingival recession, a recent systematic review reporting an average prevalence of 42%. A short, sharp, arresting pain is experienced when patent dentine tubules are exposed to stimuli such as cold food and drink, eliciting the movement of fluid within the tubules and triggering a pulpal nerve response and dental pain. Although DH pain is usually transient it can be intense and has been shown tohave a negative impact on quality of life. Treatment acts to depolarise the nerves and or block the dentine tubules, being professionally administered or over the counter. Over the counter treatment are convenient and simple to use however and many formulations show efficacy compared to negative controls, however evidence from systematic reviews shows there is no ‘gold standard’ treatment. This study aimed to test the efficacy of an experimental toothpaste containing potassium nitrate, aluminium
lactate and hydroxyapatite to reduce DH pain as compared to a potassium nitrate control toothpaste.
Methods
This was a randomised, examiner blind, two treatment arm, parallel, stratified, controlled trial in adult participants with DH. Aftera 7-day wash-in period participants with 2 sensitive teeth（Schiff >2）were randomised to test or control toothpaste. DH of the selected study teeth was assessed by tactile stimuli with a Yeaple probe, Schiff score following a drop of water at 0 °C and VAS on
global DH, at baseline pre and post supervised brushing and after 7 and 14 days of product use. DH quality of life and a fullmouth Turesky plaque score were also completed at these visits.
Results82 participants were randomised and completed the study. There was an improvement in DH pain scores in both groups, but improvements were much greater in those receiving the test toothpaste with pain reduced significantly more than those using thecontrol toothpaste at all time points for all DH measures（p = 0.005）.Furthermore, using the test as opposed to the control toothpaste resulted in a significant relative risk reduction（RRR）of DH pain of 55% immediately post supervised toothbrushing rising
to 81% after 7 and 88.6% after 14 days（p<0.001）.Mean quality of life scores improved slightly overall from baseline to visit 4 inboth groups, however, there were no significant differences between them comparing the overall score or for any individual questions. Similarly, there was no significant difference in global VAS score reported by the participants in the test and control groups
although scores favoured the test toothpaste. Plaque scores were also similar for both toothpastes at all time points.
Conclusion
The experimental toothpaste containing potassium nitrate, aluminium lactate and hydroxyapatite is effective at reducing DH pain
immediately after treatment and for up to 14 days, providing significantly more pain relief than the benchmark control potassium
nitrate control toothpaste.

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