APPLIED IN VITRO TOXICOLOGY COURSECONTACTProf. Mathieu Vinken
Department of In Vitro Toxicology
Vrije Universiteit Brussel
Laarbeeklaan 103
1090 Brussels
Belgium
Tel.: +322 477 45 87
E-mail: mvinken@vub.ac.be

Dr. Gertrude-Emilia Costin
Institute for In Vitro Sciences, Inc. (IIVS)
30 West Watkins Mill Road
Suite 100Gaithersburg MD 20878
USA
Tel.: +1301 947 6524
E-mail: ecostin@iivs.org

Bucharest - Romania
14 - 19 April 2019

ESTIV MEMBERSHIPESTIV membership is free for bachelor, master and (post)doctoral students.
The membership fee is €30 for individual members and €18 for members ofaffiliated societies. Membership benefits are:
• Reduced registration fee for the ESTIV congresses, workshops and courses.
• Reduced membership fee for affiliated societies.
• Reduced fee for the official journal of ESTIV Toxicology In Vitro.
• Free access to ESTIV newsletters and admission to the ESTIV e-mail network.
• Membership of the ESTIV Facebook page and LinkedIn.
For membership applications, please consult the ESTIV website(www.estiv.org) or contact the ESTIV secretary (secretary@estiv.org).

ASCCT MEMBERSHIPASCCT membership is $20 for students and $50 for individual regularmembers (or $90 for 2 years). Membership benefits are:
• Discounted subscription to ALTEX and Toxicology In Vitro.
• Discounted registration to ASCCT events.
• News and events updates in the in vitro and computational toxicology field.
• Access to a video archive of educational webinars given by experts in theirfield and advance registration access to upcoming webinars.
For membership applications, please consult the ASCCT website(www.ascctox.org) or contact the ASCCT secretary (info@ascct.org).

Picture: Diego Delso, delso.photo, License CC-BY-SAorganized by

SCOPEIn vitro toxicity methods are gaining importance, in particular as a response
to a number of European legislative changes that call for moremechanistically-based decision-making and limit or even prohibit the use ofanimal experimentation for risk assessment purposes. Hence, there is anurgent demand for toxicologists and risk assessors to incorporate data fromin vitro test methods into regulatory safety evaluation of chemicals. Thiscourse aims at meeting this important need by training individuals who wish
to start or pursue a career in this direction or to gain an update on the stateof-the-art of applied in vitro toxicology.

TARGET AUDIENCEThis course is intended for (post)doctoral students and early-stage scientists
from industry, academia or regulatory agencies who recently became activein the field of in vitro toxicology. Applicants should ideally have a backgroundin toxicology, biology, chemistry, (bio)medical sciences, pharmaceuticalsciences, veterinary sciences or equivalent. Attendees are expected to be
proficient in English. A maximum of 30 participants will be enrolled in thecourse on a first-come/first-served basis, yet priority will be given tomembers of ESTIV, ASCCT and affiliated societies.

COURSE ORGANIZATIONThis 6-day course is organized by the European Society of Toxicology In Vitro(ESTIV) in collaboration with the American Society for Cellular andComputational Toxicology (ASCCT) and combines cutting-edge lectures byleading experts with highly interactive group exercises. The lectures cover abroad spectrum of subjects pertinent to regulatory, screening andinvestigative in vitro toxicology. The group exercises consist of real-life casestudies in which the participants will apply the principles of in vitro toxicology
to the risk assessment of chemical substances. Furthermore, the participants
will be given the opportunity to gain hands-on experience with respect toskin and eye irritation testing in vitro.

COURSE TOPICS• European legislative framework and international guidelines for in vitro
toxicity testing of chemicals.

• Use and validation of 3R-alternative methods in Europe and the USA.
• In vitro methods for assessing cytotoxicity, skin sensitization, skin/eye
irritation/corrosion, immunotoxicity, genotoxicity, carcinogenicity anddevelopmental toxicity.
• Development and application of cell lines, organ-specific models,tridimensional and reconstructed models, bioreactors and stem cell models
in in vitro toxicology.
• Use of “omics”-based methods in in vitro toxicology.
• Good in vitro method practices/good cell culture practice.
• In vitro kinetics and in vitro-in vivo extrapolation.
• In vitro aspects of pathway-based toxicology.
• Non-animal testing technologies and strategies used for chemical hazard andrisk assessment in Europe and the USA.
• Hands-on training on skin and eye irritation testing in vitro.

PRACTICAL INFORMATION• Course dates: 14-19 April 2019.
• Course location: University of Bucharest (Bogdan Petriceicu Hasdeu Street 1)• Course language: English.
• Course capacity: 30 participants (10 seats are reserved for Romanianparticipants).
• Registration: https://estiv2019.com• Course fee: covers participation in lectures and group exercises, course notes
and other materials, lunches, coffee breaks, social event and dinner.

Academia*
Industry*

Registration before1 December 2018
€850
€1150

Registration after
1 December 2018
€950
€1350

* ESTIV and ASCCT members benefit from a €50 reduction. A maximum of 10participants originating from and based in Romania benefit from a 50%
reduction on a first-come/first-served basis. These promotional offers can not
be used in conjunction.