Kanazawa Medical University
Research Activities and Publications
VOL.282016

Kanazawa Medical University

INDEX
Code

Depaertment

Page

Code

Basic Medical Science

Depaertment

Page

0475

Department of Otorhinolaryngology

・・・・・・・・

70

0100

Department of Anatomy Ⅰ・・・・・・・・

1

0485

Department of Head and Neck Surgery

・・・・・・・・

72

0110

Department of Anatomy Ⅱ・・・・・・・・

20490

Department of Dermatology

・・・・・・・・

73

0120

Department of Physiology Ⅰ・・・・・・・・

30500

Department of Urology

・・・・・・・・

75

0130

Department of Physiology Ⅱ・・・・・・・・

50510

Department of Obstetrics and Gynecology

・・・・・・・・

77

0140

Department of Biochemistry Ⅰ・・・・・・・・

70520

Department of Anesthesiology and0150

Department of Biochemistry Ⅱ・・・・・・・・

8

・・・・・・・・

79

0160

Department of Pharmacology

・・・・・・・・

90170

Department of Pathology Ⅰ・・・・・・・・

11

Medicine・・・・・・・・

80

0180

Department of Pathology Ⅱ・・・・・・・・

12

Department of Emergency Medicine

・・・・・・・・

81

Perioperative Medicine
0540

0550

Department of Physical and Rehabilitation

0190

Department of Microbiology

・・・・・・・・

13

0570

Department of Community Medicine

・・・・・・・・

82

0200

Department of Immunology

・・・・・・・・

140575

Department of Gastroenterological Endoscopy

・・・・・・・・

84

0210

Department of Medical Zoology

・・・・・・・・

160580

Department of Oral and Maxillofacial Surgery

・・・・・・・・

86

0220

Department of Pathology and Laboratory
・・・・・・・・

17
8010

Fundamental Nursing

・・・・・・・・

87

Medicine・・・・・・・・

20

8040

Maternity Nursing・Midwifery

・・・・・・・・

89

0240

Department of Epidemiology and Public Heaｌｔｈ・・・・・・・・

22

8050

Pediatric Nursing

・・・・・・・・

90

0250

Department of Legal Medicine

・・・・・・・・

24

8060

Adult Nursing

・・・・・・・・

91

0260

Department of Medical Education

・・・・・・・・

25

8070

Gerontological Nursing

・・・・・・・・

93

edicine0230

Department of Social and Environmental

Clinical Medicine

School of Nursing

8080

Community Health Nursing

・・・・・・・・

94

8085

Psychiatric and Mental Health Nursing

・・・・・・・・

95

0300

Department of Cardiology

・・・・・・・・

26

8090

Home Care Nursing

・・・・・・・・

96

0310

Department of Respiratory Medicine

・・・・・・・・

28

8100

Medical Science・・・・・・・・

97

0320

Department of Gastroenterology

・・・・・・・・

30

0330

Department of Nephrology

・・・・・・・・

32

0340

Department of Diabetology and Endocrinology

・・・・・・・・

34

8610

Natural Science・・・・・・・・

99

0350

Department of Hematology and Immunology

・・・・・・・・

37

8620

Human Science・・・・・・・・

102

0360

Department of Neurology

・・・・・・・・

39

0363

Department of Medical Oncology

・・・・・・・・

40

0366

Department of Infectious Diseases

・・・・・・・・

41

0635

Hepatology

・・・・・・・・

104

0368

Department of General Internal Medicine

・・・・・・・・

43

0675

Health Evaluation Center・・・・・・・・

106

0370

Department of Geriatric Medicine

・・・・・・・・

45

Department of General Education

University Hospital

Medical Research Institute0380

Department of Pediatrics

・・・・・・・・

46

0390

Department of Neuropsychiatry

・・・・・・・・

48

7100

Department of Life Science・・・・・・・・

109

0400

Department of Radiology

・・・・・・・・

50

7200

Department of Advanced Medicine

・・・・・・・・

112

・・・・・・・・

115

・・・・・・・・

117

・・・・・・・・

119

0410

Department of Cardiovascular Surgery

・・・・・・・・

52

7310

Division of Innovative Research

0415

Department of Thoracic Surgery

・・・・・・・・

53

7320

Division of Vision Research for Environmental

0420

Department of General and Digestive Surgery

・・・・・・・・

56

0430

Department of Orthopedics Surgery

・・・・・・・・

59

0440

Department of Neurosurgery

・・・・・・・・

62

Surgery・・・・・・・・

64

0460

Department of Pediatric Surgery

・・・・・・・・

66

0470

Department of Ophthalmology

・・・・・・・・

68

0450

Department of Plastic and Reconstructive

Health
7340

Division of Anticipatory Molecular Food Scienceand echnology

7350

Division of Systems Bioscience for Drug
Discovery Based on Intrinsically Disordered

7400

Proteins

・・・・・・・・

121

Research Support Cente・・・・・・・・

123

Code

Depaertment

Page

Code

Affiliated Institution
9030

Northern Noto Institute of Community
Medicine・・・・・・・・

125

・・・・・・・・

126

Himi Municipal Hospital
9100

Himi Municipal Hospital

Depaertment

Page

Basic Medical Science

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Associate Professor

SAKATA Hiromi

Developmental toxicology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji:Galectin-4 expression isdown-regulated in response to autophagy during differentiation of rat trophoblast cells, SCIENTIFIC REPORTS,
6:1-11, 2016.

Presentations at Conference
International Conference (Presentations)
0100I001

T.Tsukada, H.Shimada, W.He, H.Sakata-Haga, H.Iizuka, T.Hatta:Critical role of SOCS3 in the suppression of thematernal–fetal leukemia inhibitory factor signal relay pathway for fetal brain development, 5th Conference on
Prenatal Programming and Toxicity, Kokura, 2016.

-1-

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

HONMA Satoru

gross anatomy

Senior Assistant Professor

SONOMURA Takahiro

Neuroanatomy, immunohistochemistry, electron microscopy, 3D
reconstruction

Senior Assistant Professor

KOMINAMI Rieko

neuroanatomy

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, ontogenesis,
hippocampus, reconstruction, electron microscopy, vascularization, Neuroanatomy, FIB/SEM, BMI, gustatory

Outline of Research
Theme of researches
1)Human gross anatomy
2)Neural network of the basal ganglia
3)Circuit of gustatory in the central nervous system
4)Tissue reconstruction and vascularization of human hippocampus

Publications
Originals
0110B001(T.Tsukahara), M.Masuhara, H.Iwai, T.Sonomura, T.Sato:The effect of repeated stress on KCC2 and NKCC1
immunoreactivity in the hippocampus of female mice, Data in Brief, 6:521-525, 2016.

-2-

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Senior Assistant Professor

ONO Munenori

Neuroscience

Senior Assistant Professor

TAJIMA Nobuyoshi

molecular physiology

Assistant Professor

UCHIUMI Osamu

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal,
horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision,
intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released
or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron
excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellularmessenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic
efficiency and neuron excitability.

Publications
Originals
0120B001

M.Ono, DC.Bishop, DL.Oliver:Long-lasting sound-evoked afterdischarge in the auditory midbrain, Scientific
Reports, 6:20757;1-11, 2016.

0120B002

J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato:Learning impairment byminimal cortical injury in a mouse model of Alzheimer's disease., Brain research, 1637:56-63, 2016.

0120B003(H.Yoshimura), T.Sugai, N.Kato, T.Tominaga, Y.Tominaga, T.Hasegawa, C.Yao, T.Akamatsu:Interplay between
non-NMDA and NMDA receptor activation during oscillatory wave propagation: Analyses of caffeine-induced
oscillations in the visual cortex of rats., Neural networks : the official journal of the International Neural Network
Society, 79:141-149, 2016.

0120B004(Y.Itokazu), N.Tajima, L.Kerosuo, P.Somerharju, H.Sariola, K.Yu Robert, R.Käkelä:A2B5+/GFAP+ Cells of Rat
Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study., Neurochemical
research, 41:7;1527-1544, 2016.

0120B005

T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio:Long-term activation ofgroup I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root
ganglia, Frontiers in Cellular Neuroscience, 10:79, 2016.

-3-

Presentations at Conference
International Conference (Presentations)
0120I001

M.Ono, DC.Bishop, DL.Oliver:Long-Lasting Sound-Evoked Afterdischarge in the Auditory Midbrain, ARO 39th
midwinter meeting, San Diego, 2016.

0120I002(C.Chen), M.Cheng, T.Ito, M.Ono, S.Song:Cell type specific connectivity and function in auditory midbrain,
Neuroscience 2016, San Diego, 2016.

-4-

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Professor

KURATA Yasutaka

Cardiac Electrophysiology

Associate Professor

TANIDA Mamoru

Circulatory Physiology

Assistant Professor

KUDA Yuichi

Circulatory Physiology

Keywords of Researchphysiology, circulatory shock, systemic anaphylaxis, pulmonary circulation, pulmonary edema, cardiac electrophysiology, ion
channels, pacemaker mechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis,
nonlinear dynamics, computer simulation, sympathetic nervous system, smooth muscle, vascular electrophysiology, arthery,vein

Outline of Research
Our works widely cover the area of cardiovascular physiology and autonomic nervous system. We are particularly interested
in the mechanisms of regulations of organ circulation under normal and anaphylactic conditions, and the mechanisms ofcardiac automaticity and arrhythmias as well as their regulations. We also explored the inhibitory effect of angiotensin II on
inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, and the possible roles of pacemaker currents in robust
pacemaking and driving of biological pacemakers, and dynamical mechanisms of early afterdepolarizations in long QT
syndrome. We also aim to elucidate the central mechanisms for autonomic regulations of appetite-related hormones andcirculatory shock.

Publications
Originals
0130B001

J.Song, M.Tanida, T.Shibamoto, T.Zhang, M.Wang, Y.Kuda, Y.Kurata.:The role of lumbar sympathetic nerves inregulation of blood flow to skeletal muscle during anaphylactic hypotension in anesthetized rats., 11:3;e0150882,
2016.

0130B002

M.Tanida, M.Takada, A.Kato-Kataoka, M.Kawai, K.Miyazaki, T.Shibamoto:Intragastric injection of Lactobacillus
casei strain Shirota suppressed spleen sympathetic activation by central corticotrophin-releasing factor orperipheral 2-deoxy-d-glucose in anesthetized rats., Neuroscience Letters., 619:114-120, 2016.

0130B003

M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, T.Zhang, J.Song , K.Mukai, Y.Kurata:The responses of pulmonary andsystemic circulation and airway to allergic mediators in anesthetized rats., Biological and Pharmaceutical Bulletin,
39:(4);556-563, 2016.

0130B004(K.Kimura), M.Tanida, N.Nagata, Y.Inaba, H.Watanabe, M.Nagashimada, T.Ota, S.Asahara, Y.Kido,
M.Matsumoto, K.Toshinai , M.Nakazato, T.Shibamoto, S.Kaneko, M.Kasuga, H.Inoue:Central Insulin Action
Activates Kupffer Cells by Suppressing Hepatic Vagal Activation via the Nicotinic Alpha 7 Acetylcholine
Receptor., Cell Reports, 14:(10);2362-2374, 2016.

-5-

0130B005(T.Kondo), I.Hisatome, S.Yoshimura, E.Mahati, T.Notsu, P.Li , K.Iitsuka, M.Kato, K.Ogura, J.Miake, T.Aiba,
W.Shimizu, Y.Kurata, S.Sakata, N.Nakasone, H.Ninomiya, A.Nakai, K.Higaki, Y.Kawata, Y.Shirayoshi, A.Yoshida,
K.Yamamoto.:Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient:
Instability of the mutant protein and stabilization by heat shock factor 1., Journal of Arrhythmia, 32:(5);433-440,
2016.

0130B006(N.Yamamoto), Y.Fujii, R.Kasahara, M.Tanida, K.Ohora, Y.Ono, K.Suzuki, K.Sobue:Simvastatin and atorvastatin
facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes
through activation of MAPK/Erk1/2 pathways., 64:6;952-962, 2016.

0130B007(T.Sogo), K.Morikawa, Y.Kurata, P.Li, T.Ichinose, S.Yuasa, D.Nozaki, J.Miake, H.Ninomiya, W.Shimizu,K.Fukuda,
K.Yamamoto, Y.Shirayoshi, I.Hisatome I.:Electrophysiological properties of iPS cell-derived cardiomyocytes from apatient with long QT syndrome type 1 harboring the novel mutation M437V of KCNQ1., Regenerative Therapy,
4:9-17, 2016.

0130B008(E.Mahati), P.Li, Y.Kurata, N.Maharani, N.Ikeda, S.Sakata, K.Ogura, J.Miake, T.Aiba, W.Shimizu, N.Nakasone,
H.Ninomiya, K.Higaki, K.Yamamoto, A.Nakai, Y.Shirayoshi, I.Hisatome:M3 muscarinic receptor signaling stabilingstabilizes a novel mutant human ether-a-go-go-related gene channel protein via phosphorylation of heat shock
factor 1 in transfected cells., Circulation Journal, 80:2443-2452, 2016.

0130B009

M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, T.Zhang, J.Song, Y.Kurata:The responses of pulmonary and systemic
circulation and airway to anaphylactic mediators in anesthetized BALB/c mice., Life Sciences, 147:77-84, 2016.

Presentations at Conference
International Conference (Symposium)
0130H001

Y.Kurata, I.Hisatome, T.Shibamoto:Mechanisms of sinoatrial node pacemaking: novel insights into roles of thepacemaker current If from bifurcation analysis of mathematical models, The 2016 International Symposium on
Nonlinear Theory and its Applications (NOLTA2016), Yugawara, 2016.

International Conference (Presentations)
0130I001

M.Tanida, T.Shibamoto:Effects of intracerebroventricular injection of nesfatin-1 on autonomic nerve activities inrats and mice, Experimental Biology 2016, San diego, 2016.

0130I002

M.Tanida, T.Zhang, T.Shibamoto:Renal sympathetic response to hemorrhagic shock in anesthetized mice, 38th
Annual Conference on Shock, Tokyo, 2016.

-6-

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SAKASAI Ryo

DNA damage response induced by anti-cancer drugs

Assistant Professor

SUNATANI Yumi

Function of DNA damage repair protein

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001(HJ.Baek), YM.Lee, TH.Kim, JY.Kim, EJ.Park, K.Iwabuchi, L.Mishra, SS.Kim:Caspase-3/7-mediated Cleavage of
β2-spectrin is Required for Acetaminophen-induced Liver Damage., International journal of biological sciences,
12:2;172-183, 2016.

0140B002(M.Iimori), S.Watanabe, S.Kiyonari, K.Matsuoka, R.Sakasai, H.Saeki, E.Oki, H.Kitao, Y.Maehara:Phosphorylationof EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability., Nature Communications,
7:11117, 2016.

Presentations at Conference
International Conference (Presentations)
0140I001

R.Sakasai, Y.Sunatani, T.Matsui, K.Iwabuchi:Topoisomerase II switching is regulated by ubiquitination, Gordon
Research Conference, DNA Topoisomerase in Biology & Medicine, Sunday River, 2016.

-7-

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Senior Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Assistant Professor

TAKATSUJI-SAITO
Hidehito

neuroscience, molecular biology, regenerative medicine

Faculty

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor,

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

0150B002

H.Saito, K.Iwabuchi, N.Fusaki, F. Ito:Generation of induced pluripotent stem cells from human melanoma tumorinfiltrating lymphocytes, Journal of Visualized Experiments, 117:e54375, 2016.

-8-

0160

Department of Pharmacology

Faculty
Title

Name

Professor

Field of Specialization

Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascular
ISHIBASHI Takaharu
systemElectrophysiology and behavioural pharmacology in central and
MASUOKA Takayoshi
periphenal nervous system
NISHIO Matomo

Professor(Additional Post)
Senior Assistant Professor
Senior Assistant Professor

YOSHIDA Junko

Pharmacology in cardiovascular system, Cancer chemotherapy

Assistant Professor

IMAIZUMI Noriko

Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitricoxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation,
cell biology, hippocampal synapses, muscarinic acetylcholine receptor, peripheral sensory neuron, autonomic neuron,central nervous system, metabotropic glutamate receptor, receptorology,

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system
６ Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation

Books
0160A001

I.Muramatsu, H.Yoshiki, K.Sada, J.Uwada, T.Taniguchi, T.Masuoka, M.Nishio:Binding Method for Detection ofMuscarinic Acetylcholine Receptors in Receptor's Natural Environment, Muscarinic Receptor: From Structure to
Animal Models, Volume 107 of the series Neuromethods, pp 69-81, Springer, Berlin, Germany, 2016.

Publications
Originals
0160B001

I.Muramatsu, H.Yoshiki, J.Uwada, T.Masuoka, K.Sada, T.Taniguchishio Matomo:Pharmacological evidence ofspecific acetylcholine transport in rat cerebral cortex and other brain regions., Journal of Neurochemistry,
139:4;566-575, 2016.

0160B002

T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio:Long-term activation ofgroup I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root
ganglia, Frontiers in Cellular Neuroscience, 10:79, 2016.

-9-

Presentations at Conference
International Conference (Symposium)
0160H001

T.Masuoka, T.Ishibashi, M.Nishio:Possible contribution of glutamate receptors in ocular hyperalgesia, XXI Biennial
Meeting of the International Society for Eye Research, Tokyo, 2016.

International Conference (Presentations)
0160I001

T.Masuoka, M.Kudo, T.Ishibashi, M.Nishio:TRPA1 channel modifies membrane current induced by TRPV1channels activation in dorsal root ganglion neurons, Neuroscience 2016, San Diego, 2016.

-10-

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Senior Assistant Professor

HIRATA Eishu

Tumour cell biology, Neurosurgery

Assistant Professor

TAKEDA Haruna

Mouse model for carcinogenesis、Two-photon microscopy imaging

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration,

Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer
development and invasion/metastasis, and epithelial regeneration.. We also develop the system to manipulate cell signaling
to understand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating rolesof DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.

Publications
Originals
0170B001(H.Seifert), E.Hirata, M.Gore, K.Khabra, C.Messiou, J.Larkin, E.Sahai:Extrinsic factors can mediate resistance to
BRAF inhibition in central nervous system melanoma metastases, Pigment Cell & Melanoma Research, 29:1;92100, 2016.

0170B002

H.Yoshizaki, H.Ogiso, T.Okazaki, E.Kiyokawa:Comparative lipid analysis in the normal and cancerous organoids of
MDCK cells., Journal of Biochemistry, 159:6;573-584, 2016.

0170B003

T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:Propolis, a constituent of honey, inhibits
the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, Journal of
Ophthalmology, 2016;1917093, 2016.

0170B004

H.Takeda, Alistair G.Rust, Jerrold M.Ward, Christopher Chin Kuan Yew, Nancy A.Jenkins, Neal
G.Copeland:Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastriccancer development, Proceedings of the National Academy of Sciences of the United States of America,
113:14;2057-2065, 2016.

Reviews
0170C001

E.Hirata, E.Kiyokawa:Future perspective of single-molecule FRET biosensors and intravital FRET microscopy.,
Biophysical Journal, 111:6;1103-1111, 2016.

Presentations at Conference
International Conference (Presentations)
0170I001

E.Kubo, T.Shibata, S.Shibata, H.Sasaki, E.Kiyokawa, M.Ikawa, DP.Singh:Knock-down of Tropomyosin 2 created by
CRISPR-CAS9 in mouse induces age-related-cataract, The Association for Research in Vision and Ophthalmology
2016, Seattle, 2016.

-11-

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Diagnostic pathology of tumor

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchlung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic histopathology, phospholipid,
regeneration of cartilage, steroid induced femoral neuritis, mesenchymal stem cell, matrix metalloproteinase, bone tumor,
molecular genetics, molecular pathology, neuronal death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand,
NFκB

Outline of Research
1. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
2. Molecular pathological diagnosis by FISH using probes origination from BAC clones and RT-PCR methods.
3. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.

Publications
Originals
0180B001(K.Higashi), T.Yamagishi, Y.Ueda, Y.Ishigaki, M.Shimasaki, Y.Nakamura, M.Oguchi, T.Takegami, M.Sagawa,
H.Tonami:Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma., Annals of
nuclear medicine, 30:10;708-715, 2016.

0180B002

K.Usuda, M.Sagawa, S.Maeda, N.Motono, M.Tanaka, Y.Machida, M.Matoba, T.Matsui, N.Watanabe, H.Tonami,
Y.Ueda, H.Uramoto:Diagnostic performance of whole-body diffusion-weighted imaging compared to PET-CT plus
brain MRI in staging clinically resectable lung cancer, Asian Pacific journal of cancer prevention : APJCP,
17:6;2775-2780, 2016.

0180B003

S.Ueda, T.Ichiseki, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:The timing of glucocorticoid-induced osteocytic
cell necrosis under hypoxia, International journal of clinical and experimental pathology, 9:7;7470-7475, 2016.

Presentations at Conference
International Conference (Presentations)
0180I001

Y.Machida, Y.Ueda, M.Shimazaki, M.Tanaka, N.Motono, T.Matsui, K.Usuda, H.Uramoto:Analysis of postoperative
survival in patients with resected lung adenocarcinoma according to the tumor-associated macrophages., American
Thoracic Society 2016, San Francisco, 2016.

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0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

HIGUCHI Masaya

Virology, Hematology, Oncology, Cellular biology

Associate Professor

HIMEDA Toshiki

Neurovirology

Assistant Professor

OKUWA Takako

Neurovirology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis,

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

M.Higuchi, H.Kawamura, H.Matsuki, T.Hara, M.Takahashi, S.Saito, K.Saito, S.Jiang, M.Naito, H.Kiyonari,
M.Fujii:USP10 is an essential deubiquitinase for hematopoiesis and inhibits apoptosis of long-term hematopoietic
stem cells., Stem Cell Reports, 7:1116-1129, 2016.

-13-

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Senior Assistant Professor

YABE-WADA Toshiki Immunology, Functional biochemistry, Structural biochemistry

Assistant Professor

TAKEDA Kazuya

Immunology, Neuropathology

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology

Keywords of Research
The origin, development, and function of mononuclear phagocytes, Dendritic cells, Monocytes/Macrophages, Allergic
effector cells, Innate immune responses, Cytokines

Outline of Research
Our research is focused on the regulation mechanisms of various immune responses.In the past years, we havecharacterized several proteins that are involved in cytokine trafficking and the regulation of serine protease activity using
mouse models.
Specific areas of interest include;
The origin, development, and function of mononuclear phagocytes (dendritic cells, monocytes, and macrophages).
The regulation of cytokine production from innate immune cells.
The role of endogenous serine protease inhibitors in allergic effector cells.

Publications
Originals
0200B001

T.Yabe-Wada, S.Matsuba, K.Takeda, T.Sato, M.Suyama, Y.Ohkawa, T.Takai, H.Shi, C.C. Philpott,
A.Nakamura:TLR signals posttranscriptionally regulate the cytokine trafficking mediator sortilin., Scientific
Reports, 6:26566, 2016.

0200B002(S.Saijo), A.Nagai, S.Kinjo, R.Mashimo, M. Akimoto, K.Kizawa, T.Yabe-Wada, N.Shimizu, H.Takahara, M.
Unno:Monomeric Form of Peptidylarginine Deiminase Type I Revealed by X-ray Crystallography and Small-Angle
X-ray Scattering., Journal of Molecular Biology, 428:15;3058-3073, 2016.

0200B003

M.Higashino, T.Yabe-Wada, S.Matsuda, K.Takeda, K.Anzawa, T.Mochizuki, K.Makimura, S.Saijyo, Y.Iwakura,
H.Toga, A.Nakamura:A critical role of Dectin-1 in hypersensitivity pneumonitis., Inflammation Research,
65:3;235-244, 2016.

Presentations at Conference
International Conference (Presentations)
0200I001

T.Yabe-Wada, S.Matsuba, K.Takeda, T.Sato, M.Suyama, Y.Ohkawa, H.Shi, C.C.Philpott, A.Nakamura:TLR
signals posttranscriptionally regulate the cytokine trafficking mediator sortilin, Gordon Research Conference on
Protein Processing, Trafficking and Secretion, Colby-Sawyer College in New London NH United States, 2016.

-14-

0200I003(A.Nagai), S.Saijo, S.Kinjo, R.Mashimo, M.Akimoto, K.Kizawa, T.Yabe-Wada, N.Shimizu, H.Takahara,
M.Unno:Structural Studies of Peptidylarginine Deiminase Type I using X-ray Crystallography and Small-angle Xray Scattering, 14th International Conference of the Asian Crystallographic Association, Hanoi, 2016.

-15-

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

MURAKAMI Manabu

Infection-mediated arthropod

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium, Japanese encephalitis Virus, mosquito, Culex tritaeniorhynchus, Culex tritaeniorhynchus, Aedes
albopictus

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Investigation of mosquito situation around the pigpen in Ishikawa prefecture, and JE virus distribution.

Publications
Originals
0210B001(J.Suzuki), M.Hashino, S.Matsumoto, A.Takano, H.Kawabata, N.Takada, M.Andoh, Y.Oikawa, H.Kajita, A.Uda,
K.Watanabe, T.Shimizu, M.Watarai:Detection of francisella tularensis and analysis of bacterial growth in ticks inJapan, Letters in applied microbiology, 63:4;240-246, 2016.

0210B002

M.Murakami, T.Tasaki, S.Nukuzuma, H.Minato, T.Nojima, Y.Ishigaki, T.Takegami:Japanese encephalitis virus
replication and inhibitory effect of shRNA in mice, Advances in Microbiology, 6:6;462-470, 2016.

0210B003(N.Takada), H.Iwasaki, Y.Yano, F.Ishiguro,S.Akachi, A.Uda, Y.Oikawa, M.Natsuaki, D.Hayasaka:Acari-borne
infectious diseases and tick fauna as vector found recently in Hokuriku district along Japan Sea, 27:78-80, 2016.

Case Reports
0210D001 S.Miura, Y.Oikawa, N.Ueda, M.Murakami, N.Sakata:Case of viper (Glodius blomhoffii) bites treated withhospitalization in the Ishikawa Prefecture, Noto district, Clinical Parasitology, 27:1;75-77, 2016.

-16-

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Senior Assistant Professor

NAKADA Satoko

surgical pathology

Assistant Professor

KOBAYASHI Erikosurgical pathology, molecular pathology

Assistant Professor

SHIOYA Akihiro

Surgical pathology

Assistant Professor

AIKAWA Akane

Surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, lung, mediastinum, and pleura, head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001

N.Kurose:Clinicopathological analysis between IgG4-related and non-IgG4-related diseases occurring in variousorgans and tissues: Re-evaluation of comprehensive diagnostic criteria and usefulness of interleukin-6
immunostaining, Journal of Kanazawa Medical University, 41:76-85, 2016.

0220B002(M.Kawaguchi), N.Hara, Bilim Vladimir, H.Koike, M.Suzuki, Kim Tae-Sun, Gao Nan, Dong Yu, Zhang Sheng,
Y.Fujinawa, O.Yamamoto, H.Ito, Y.Tomita, Y.Naruse, A.Sakamaki, Y.Ishii, K.Tsuneyama, M.Inoue, Itoh Johbu,
M.Yasuda, N.Sakata, Jung Cha-Gyun, S.Kanazawa, H.Akatsu, H.Minato, T.Nojima, K.Asai, Y.Miura:A diagnostic
marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistrysuggests malignant progression, BMC cancer, 16:1;805, 2016.

0220B003

M.Murakami, T.Tasaki, S.Nukuzuma, H.Minato, T.Nojima, Y.Ishigaki, T.Takegami:Japanese encephalitis virus
replication and inhibitory effect of shRNA in mice, Advances in Microbiology, 6:6;462-470, 2016.

-17-

0220B004

Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara,
H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta,
N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita,
S.Aoki:Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome,2015 version., International journal of hematology, 103:6;686-692, 2016.

0220B005

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki:Proposed diagnostic criteria, disease severity classification, and treatment strategy for a novel
disorder; TAFRO syndrome., The Japanese journal of clinical hematology, 57:10;2029-2037, 2016.

0220B006

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki, Japanese TAFRO syndrome research team: Proposed diagnostic criteria, disease severity
classification, and tretment strategy for a novel disorder;TAFRO syndrome, The Japanese Journal of Clinical
Hematology, 57:10;195-203, 2016.

0220B007

M.Noguchi, M.Noguchi, Y.Ohno, E.Morioka, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Feasibility study of axillary
reverse mapping for patients with clinically node-negative breast cancer., European journal of surgical oncology,
42:5;650-656, 2016.

0220B008(K.Tanaka), T.Hasegawa, T.Nojima, Y.Oda, J.Mizusawa, H.Fukuda, Y.Iwamoto:Prospective evaluation of Ki-67
system in histological grading of soft tissue sarcomas in the Japan Clinical Oncology Group Study JCOG0304,
World journal of surgical oncology, 14:110, 2016.

0220B009

K.Hamada, T.Itoh, K.Kawaura, S.Azukisawa, R.Kobayashi, H.Okamura, H.Kitakata, S.Urashima, T.Nojima,
M.Fujino:Findings of the margin around lesions by magnifying endoscopy with narrow-band imaging in early gastriccarcinoma and intestinal metaplasia., Journal of digestive diseases, 17:6;377-382, 2016.

Reviews
0220C001

S.Nakada, H.Minato, T.Nojima:Clinicopathological differences between variants of the NAB2-STAT6 fusion gene insolitary fibrous tumors of the meninges and extra-central nervous system., Brain tumor pathology, 33:3;169-174,
2016.

Case Reports
0220D001

S.Mizuguchi, M.Nakano, T.Terauchi, M.Takenaka, N.Kurose, H.Minato, T.Nojima, M.Doai:A case report ofprimary mammary Rosai-Dorfman disease with contralateral micro-invasive ductal carcinoma, The Journal of theJapanese Society of Clinical Cytology, 55:5;329-333, 2016.

0220D002

A.Shioya, K.Saito, S.Nakada, H.Minato, T.Nojima:A case of diffuse pulmonary meningiotheliomatosis, Japanese
Journal of Diagnostic Pathology, 33:350-354, 2016.

0220D003 (K.Mizuguchi), H.Minato, H.Onishi, Y.Mitani, J.Kawai:Cytopathological findings of primary pulmonary Ewing familyof tumors with EWSR1 translocation: A case report, Thoracic cancer, 7:5;602-606, 2016.
0220D004 T.Onishi, N.Ueda, S.Miura, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, S.Nakada: A case of invasive
cholangiocarcinoma with diffuse biliary intraepithelial neoplasia, Journal of Japan Biliary Association, 30:4;741-748,
2016.
0220D005 (Y.Sasagawa), O.Tachibana, A.Nakagawa, S.Nakada, T.Nojima, D.Koya, H.Iizuka:Rapid enlargement of an
intracranial germ cell tumor after gonadotropin hormone therapy, JOURNAL OF CLINICAL NEUROSCIENCE,
31:185-188, 2016.

-18-

Presentations at Conference
International Conference (Presentations)
0220I001

Y.Nakano, M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDGPET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th Annual
Asian Oncology Summit, 12th Annual Conference of the OOTR and Kyoto Breast Cancer Consensus Conference
2016, Kyoto, 2016.

0220I002

Y.Ohno, M.Noguchi, E.Morioka, M.Noguchi, Y.Nakano, T.Kosaka, H.Minato:Tangenitial frozen section analysis forthe surgical margins in breast-conserving surgery, 8th Annual Asian Oncology Summit, 12th Annual Conference of
the OOTR and Kyoto Breast Cancer Consensus Conference 2016, Kyoto, 2016.

0220I003

H.Minato:A case of sinonasal renal cell-like adenocarcinoma (discussant), The 6th Japan-Taiwan Conjoint Slide
Conference of IAP, Nagoya, 2016.

-19-

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

ISHIZAKI Masao

Occupational Health, Job stress

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Assistant Professor

HORI Kaori

Pediatirc cardiology

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

0230B002(T.Koyama), K.Yoshita, M.Sakurai, K.Miura, Y.Naruse, N.Okuda, A.Okayama, J.Stamler, H.Ueshima,
H.Nakagawa:Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to thePrevention of Nutrient Deficiency: The INTERMAP Toyama Study, Journal of Nutritional Science andVitaminology, 62:2;101-107, 2016.

0230B003

M.Sakurai, J.Kobayashi, Y.Takeda, S.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi, H.Nakagawa:Sex Differences in
Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women,
Journal of Epidemiology, 26:8;440-446, 2016.

0230B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men, Journal of diabetes investigation, 7:3;343-351,
2016.

0230B005(Y.Isobe), M.Sakurai, Y.Kita, Y.Takeshita, H.Misu, S.Kaneko, T.Takamura:Fat-free mass and calf circumference asbody composition indices to determine non-exercise activity thermogenesis in patients with diabetes, Journal of
Diabetes Investigation, 7:3;352-358, 2016.

0230B006(H.Nakashima), K.Homma, M.Yamazaki, M.Ishizaki, K.Mawatari:Database analysis of acidic proteins from halophilic
halophilic species and their corresponding basic proteins from non-halophilic species, British Biotechnology
Journal, 14:2;1-12, 2016.

-20-

Reviews
0230C001

M.Sakurai:Effect of artificial sweeteners on glucose metabolism, Journal of the Japan Diabetes Society, 59:1;33-35,
2016.

Presentations at Conference
International Conference (Presentations)
0230I001

Y.Matsuda, R.Hashimoto, S.Takemoto, M.Ishizaki, Y.Kawasaki:A Dementia Screening Investigation for Inhabitantsof Rural Areas in Japan, The 2016 Alzheimer's Disease Congress, London, 2016.

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0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NISHINO Yoshikazu

Epidemiology of cancer, preventive medicine

Professor

NISHIJO Muneko

Environmental epidemiology, Environmental health sciences,
Epidemiology of cadmium pollution

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Senior Assistant Professor

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Keywords of Research
epidemiology, public health, cancer, hypertension, diabetes mellitus, screening, shift work, nutrition, calcium, stress,smoking, insulin resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractabledisease, cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid
peroxide, community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(D.Van Tung), T.Kido, S.Honma, HD.Manh, DD.Nhu, R.Okamoto, S.Maruzeni, M.Nishijo, H.Nakagawa, PT.Ngoc,
N.Van Toan, NN.Hung, NH.Minh, K.Son Le:Low birth weight of Vietnamese infants is related to their mother's
dioxin and glucocorticoid levels, Environmental science and pollution research international, 23:11;10922-10929,
2016.

0240B002(XL.Sun), T.Kido, S.Honma, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, T.Nakano, E.Koh,
T.Takasuga, DD.Nhu, NN.Hung, K.Son Le:Influence of dioxin exposure upon levels of prostate-specific antigen
and steroid hormones in Vietnamese men, Environmental science and pollution research international, 23:8;78077813, 2016.

0240B003

PT.Tai, M.Nishijo, TN.Nghi, H.Nakagawa. H.Van Luong, TH.Anh, H.Nishijo:Effects of Perinatal Dioxin Exposureon Development of Children during the First 3 Years of Life., The Journal of pediatrics, 175:159-166, 2016.

0240B004(K.Nakamura), M.Sakurai, Y.Morikawa, S.Nagasawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa:Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective
Study in Normoglycemic Japanese Men, Experimental and clinical endocrinology & diabetes : official journal,
German Society of Endocrinology [and] German Diabetes Association, 25:1;12-20, 2016.

0240B005

Tran Nghi Ngoc, Pham Tai The, K.Ozawa, M.Nishijo, Nguyen Anh Thi Nguyet; Tran Tuong Quy, Hoang Luong
Van, Tran Anh Hai, Phan Vu Huy Anh, A.Nakai, Y.Nishino, H.Nishijo:Impacts of Perinatal Dioxin Exposure on
Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year FollowUp., PLOS ONE, 11:1;e0147655, 2016.

-22-

0240B006(S.Virani), KM.Rentschler, M.Nishijo, W.Ruangyuttikarn, W.Swaddiwudhipong, N.Basu, LS.Rozek:DNA methylation
is differentially associated with environmental cadmium exposure based on sex and smoking status, Chemosphere,
145:284-290, 2016.

0240B007

C.Chen, P.Xun, M.Nishijo, S.Carter, K.He:Cadmium exposure and risk of prostate cancer: a meta-analysis ofcohort and case-control studies among the general and occupational populations, Scientific reports, 6:25814, 2016.

0240B008(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

0240B009

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men., Journal of diabetes investigation, 7:3;343-351,
2016.

0240B010

M.Sakurai, J.Kobayashi, Y.Takeda, S.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi, H.Nakagawa:Sex Differences in
Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women,
Journal of Epidemiology, 26:8;440-446, 2016.

0240B011

Y.Hamazaki, Y.Morikawa, S.Morimoto, H.Nakagawa:Difference in the impact of homebound status on functional
decline between independent older men and women: A 2 year follow-up study., Japan journal of nursing science,
13:2;265-272, 2016.

Reviews
0240C001(Sauvaget Catherine), Y.Nishino, R.Konno, T.Tase, T.Morimoto, S.Hisamichi:Challenges in breast and cervicalcancer control in Japan, The Lancet Oncology, 17:e305-e312, 2016.

0240C002(C.Chen), P.Xun, M.Nishijo, K.He:Cadmium exposure and risk of lung cancer: a meta-analysis of cohort and casecontrol studies among general and occupational populations, Journal of exposure science & environmental
epidemiology, 26:5;437-444, 2016.

0240C003

Y.Nishino:Importance of the national canser registry in solving problems of statistics obtained from populationbased cancer registries in Japan, Journal of Kanazawa Medical University, 41:3;73-75, 2016.

Presentations at Conference
International Conference (Key Note Lecture)
0240G001

M.Nishijo, PN.Nghi, PT.Tai, H.Nishijo, Y.Nishino:Role of AHR signaling in effects on neurodevelopment in
Vietnamese children perinatelly exposed to Agent Orange, AHR2016 The aryl hydrocarbon Receptor as a Central
Mediator of Health and Disease, Rochester, 2016.

International Conference (Presentations)
0240I001

M.Nishijo, PN.Thao, PT.Tai, T.Anh, H.Boda, S.Nagasawa, Y.Nishino, H.Nishijo:Neurotoxic effects of perinatal
dioxin exposure on children in Vietnam:Two birth cohort studiies in hot spots of dioxin contamination from Agent
Orange, PPToxⅤ, Kitakyusyu, 2016.

0240I002

PN.Thao, M.Nishijo, PT.Tai, H.Nishijo, S.Nagasawa, Y.Nishino:A case control study of neurotoxic effects ofperinatal dioxin exposure on children of 2years of age in Vietnam, PPToxⅤ, Kitakyusyu, 2016.

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0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

MIZUKAMI Hajime

Legal Medicine,Forensic pathology,DNA polymorphism

Assistant Professor

KOBAYASHI
Masamune

Legal medicine,DNA polymorphism

Assistant Professor

TAKESHITA Hiroshi

Legal medicine,Forensic pathology

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K,

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Case Reports
0250D001

H.Mizukami, M.Kobayashi, H.Takeshita, S.Takahashi, S.Hara, S.Mori, F.Kuriiwa, T.Fukunaga:An Autopsy Case ofa Woman Who Died Suddenky of Acute Myelogenous Leukemia, 59:47-52, 2016.

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0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

HORI Ariyuki

Professor

YASUDA Yukio

Senior Assistant Professor

TAKAMURA Akiteru

Comunity-based Medical Education, Simulated education

Senior Assistant Professor

KURODA Naohiro

medical informatics, electronic medical record system, medical
educatin

Faculty

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
undergraduate clinical teaching, graduate education of physicians,
medical education

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL,

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Reviews
0260C001

A.Takamura:The new era of postgraduate certified general practice training in Japan., Education for primary care :an official publication of the Association of Course Organisers, National Association of GP Tutors, World
Organisation of Family Doctors, 27:5;409-412, 2016.

-25-

Clinical Medicine

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Associate Professor

KAWAI Yasuyuki

Associate Professor

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Senior Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

WATANABE Makoto

Ischemic heart disease, Coronary intervention

Assistant Professor

TAKANO Shintaro

Arrhythmai, Catheter ablation

Assistant Professor(Additional Post)

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Ischemic heart disease, Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001

S.Takano, K.Fujibayashi, N.Fujioka, E.Ueno, M.Wakasa, Y.Kawai, K.Kajinami:Circulating Glutamate and Taurine
Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation, Disease
Markers, 2016:1-7, 2016.

-26-

0300B002(K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka,
T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node,
K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito:A possible role for
HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, Drug metabolism and pharmacokinetics,
31:6;467-470, 2016.

0300B003

K.Kajinami:Lipoprotein(a): Revisiting a Next Therapeutic Target., Circulation journal, 80:2;329-331, 2016.

0300B004

Y.Kawai, M.Kitayama, H.Akao, A.Motoyama, T.Tsuchiya, K.Kajinami:A case of coronary rupture andpseudoaneurysm formation after fracture of implanted paclitaxel-eluting stents., Cardiovascular intervention andtherapeutics, 31:3;231-237, 2016.

0300B005(K.Suzuki), M.Takahara, Y.Shintani, A.Tanaka, Y.Soga, T.Yamaoka, A.Tosaka, A.Sasaki, D.Kawasaki, T.Tsuchiya,
A.Kozuki, O.Iida:Retrospective Multicenter Comparison of S.M.A.R.T. CONTROL and MISAGO Stents in
Treatment of Femoropopliteal Lesions., Journal of vascular and interventional radiology : JVIR, 27:11;1642-1649,
2016.

0300B006

T.Tsuchiya, T.Takamura, Y.Soga, O.Iida, K.Hirano, K.Suzuki, T.Yamaoka, Y.Miyashita, M.Kitayama,
K.Kajinami:Clinical impact and risk stratification of balloon angioplasty for femoropopliteal disease in nitinol
stenting era: Retrospective multicenter study using propensity score matching analysis., SAGE open medicine,
4:1-12, 2016.

0300B007

W.Fujita, I.Matsunari, H.Aoki, S G.Nekolla, K.Kajinami:Prediction of all-cause death using (11)Chydroxyephedrine positron emission tomography in Japanese patients with left ventricular dysfunction., Annals of
nuclear medicine, 30:7;461-467, 2016.

Case Reports
0300D001

Y.Kawai, M.Kitayama, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi, M.Watanabe, T.Takamura,
H.Akao, T.Tsuchiya, K.Kajinami:Chronic total occlusions of the right coronary and left anterior descending
coronary arteries in a young adult patient with antiphospholipid syndrome, Journal of Cardiology Cases, 14:2;4648, 2016.

0300D002 T.Takahashi, N.Watanabe, M.Wakasa, K.Kajinami, H.Tonami:18F-FDG PET/CT for Detecting Sarcoma of the
Aorta in a Patient with Takayasu Arteritis, Nuclear medicine and molecular imaging, 50:2;171-172, 2016.

Presentations at Conference
International Conference (Presentations)
0300I001

E.Ueno, K.Fujibayashi, J.Sawaguchi, Y.Yasuda, S.Takano, R.Saito, M.Wakasa, N.Fujioka, Y.Kawai,
K.Kajinami:Prothrombin activation fragment(F1+2) as an index of anticoagulant therapy with factor Xa inhibitor in
atrial fibrillation, ESC Congress 2016, Roma, 2016.

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0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Professor

ISHIZAKI Takeshi

Pulmonary circulation

Associate Professor

MIZUNO Shirolung cell and molecular biology，COPD

Associate Professor(Additional Post)

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Senior Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Senior Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

SHINOMIYA Shohei

clinical respiratory medicine

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

KAMEDA Mari

clinical respiratory medicine

Assistant Professor

KATO Ryochronic obstructive pulmonary disease

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001

R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki,
N.F.Voelkel, H.Toga:Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic
obstructive pulmonary disease., Respiratory research, 17:1;139-151, 2016.

0310B002

M.Higashino, T.Yabe, S.Matsuda, K.Takeda, K.Anzawa, T.Mochizuki, K.Makimura, S.Saijyo, Y.Iwakura, H.Toga,
A.Nakamura:A critical role of Dectin-1 in hypersensitivity pneumonitis., Inflammation Research, 65:3;235-244,
2016.

-28-

0310B003

N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, H.Toga, M.Matoba, M.Sagawa: The therapeutic strategy forclinical stage IA non-small cell lung cancer patients who are ineligible for lobectomy, Haigan, 56:3;183-188, 2016.

Case Reports
0310D001

Y.Takahara, M.Nojiri, K.Kojima, S.Mizuno, K.Osanai, H.Toga:A Case of EGFR Mutation-positive Combined
Small-cell Lung Carcinoma in a Nonsmoker in Whom Palliative Treatment with Gefitinib Was Successful, Haigan,
56:2;124-129, 2016.

0310D002

Y.Takahara, K.Nishiki, K.Nakase, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa,S.Mizuno, K.Osanai, H.Toga:A Case of Diffuse Pleural Invasion of Pseudomesotheliomatous Carcinoma with EGFR
Mutation Diagnosed by Thoracoscopic Biopsy, The Journal of the Japan Society for Respiratory Endoscopy,
38:3;183-189, 2016.

0310D003(M.Morikawa), Y.Fukuda, Y.Terasaki, H.Itoh, Y.Demura, M.Sasaki, Y.Imamura, C.Honjo, Y.Umeda, M.Anzai,
S.Ameshima, T.Ishizaki, T.Ishizuka:Osteogenesis Imperfecta Associated with Dendriform Pulmonary Ossification.,
American journal of respiratory and critical care medicine, 193:4;460-461, 2016.

0310D004

Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hairhypoplasia associated with isolated hypoganglionosis: A case report., Congenital anomalies, 52:32-34, 2016.

0310D005 (A.Takeuchi), N.Yamamoto, K.Hayashi, S.Miwa, M.Takahira, K.Fukui, T.Oikawa, H.Tsuchiya:Tenosynovial giant
cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant
tumors: report of two cases., BMC musculoskeletal disorders, 17:180, 2016.

Presentations at Conference
International Conference (Presentations)
0310I001

S.Mizuno:Circulating micro-RNA profiling of animal model of pulmonary hypertension, 4th International Issyk KulLeh Symposium 2016, Kyrgyz, 2016.

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0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Associate Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Associate Professor(Additional Post)SHIMASAKI Takeo

Molecular Oncology, Pancreatic cancer , tissue engineering．

Senior Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Senior Assistant Professor

HAYASHI Ranji

Inflammatory Bowel Disease

Assistant Professor

NOMURA Tomoe

Gastro-intestinal disorders

Assistant Professor

OOTA Masaｆumi

Faculty

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0320B001(T.Tahara), T.Shibata, T.Kawamura, T.Ishizuka, M.Okubo, M.Nagasaka, Y.Nakagawa, T.Arisawa, N.Ohmiya,
I.Hirata:Telomere length in non-neoplastic gastric mucosa and its relationship to H.pylori infection,degree ofgastritis,and NSAID use, Clinical and Experimental Medicine, 16:1;65-71, 2016.

0320B002

K.Tamura, N.Hayashi, J.George, M.Toshikuni, T.Arisawa, J.Hiratake, M.Tsuchishima, M.Tsutsumi:GGsTop, anovel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.,
American journal of physiology. Gastrointestinal and liver physiology, 311:2;Ｇ305-Ｇ312, 2016.

-30-

0320B003

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

Reviews
0320C001

T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto:Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

0320C002(T.Domoto), Pyko Ilya V, T.Furuta, K.Miyashita, M.Uehara, T.Shimasaki, M.Nakada, T.Minamoto:Glycogensynthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy., Cancer science,
107:10;1363-1372, 2016.

Presentations at Conference
International Conference (Presentations)
0320I001

T.Arisawa, M.Ota, T.Tahara, J.Wu, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:A
polymorphisms of DNMT3A gene is clisely associated with the severity of gastric mucosal atrophy, APDW2016,
Kobe, 2016.

0320I002

J.Wu, T.Arisawa, T.Tahara, M.Ota, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:The
association between genetic polymorphisms of DNMT3A(rs6733868 and rs13428812)and the susceptibility to thegastric cancer in japan, APDW2016, Kobe, 2016.

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0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Senior Assistant Professor

ADACHI Hiroki

Clinical nephrology

Senior Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Assistant Professor

OKINO Kazuaki

Clinical nephrology

Assistant Professor

MUKAI Kiyotaka

Clinical nephrology

Assistant Professor

OKUSHI Yuki

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

Publications
Originals
0330B001

H.Yokoyama, I.Narita, H.Sugiyama, M.Nagata, H.Sato, Y.Ueda, S.Matsuo:Drug-induced kidney disease: a study of
the Japan Renal Biopsy Registry from 2007 to 2015., Clinical and experimental nephrology, 20:5;720-730, 2016.

-32-

0330B002

H.Adachi, K.Nakayama, N.Hayashi, Y.Matsui, K.Fujimoto, H.Yamaya, H.Tonami, H.Yokoyama:Adiponectin
Fractions Influence the Development of Posttransplant Diabetes Mellitus and Cardiovascular Disease in Japanese
Renal Transplant Recipients, PLoS one, 11:10;e0163899, 2016.

0330B003(H.Komatsu), S.Fujimoto, N.Yoshikawa, H.Kitamura, H.Sugiyama, H.Yokoyama:Clinical manifestations of HenochSchönlein purpura nephritis and IgA nephropathy: comparative analysis of data from the Japan Renal Biopsy
Registry (J-RBR), Clinical and experimental nephrology, 20:4;552-560, 2016.

0330B004

M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, T.Zhang, J.Song , K.Mukai, Y.Kurata:The responses of pulmonary andsystemic circulation and airway to allergic mediators in anesthetized rats., Biological and Pharmaceutical Bulletin,
39:4;556-563, 2016.

0330B005

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

Others
0330F001(J.Usui), K.Yamagata, E.Imai, H.Okuyama, H.Kajiyama, H.Kanamori, S.Kaneko, E.Kono, Y.Sakai, N.Sakai,
Y.Sakamaki, Y.Taniguchi, K.Nakai, H.Nishiwaki, S.Hirata, H.Yamaya, S.Tsuruoka, Y.Terada, H.Yokoyama,
T.Wada, I.Narita:Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version, Clinicaland experimental nephrology, 20:6;827-831, 2016.

Presentations at Conference
International Conference (Symposium)
0330H001

H.Yokoyama:Data on tacrolimus for maintenance therapy of lupus nephritis, Lupus Nephritis Expert Meeting,Tokyo, 2016.

International Conference (Presentations)
0330I001

Y.Matsui, N.Hayashi, J.Imura, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:DNA double-strand breaks induced
intractable glomerular fibrosis in renal allografts, Transplantation Science Symposium (TSS) Asian Regional Meeting
2016, Tokyo, 2016.

0330I002

H.Yokoyama, H.Yamaya, H.Sugiyama, I.Narita:Drug-Induced glomerular kidney disease in Japan, 53rd Congress
ERA-EDTA in Vienna Austria, Vienna Austria, 2016.

0330I003

N.Hayashi, Y.Matsu, J.Imura, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:Prevalence of M-type phospholipase
A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A(THSD7A) in the glomerular deposits ofJapanese membranous nephropathy, 53rd Congress ERA-EDTA in Vienna Austria, Vienna, 2016.

0330I004

H.Adachi, K.Nakayama, N.Hayashi, Y.Matsui, K.Fujimoto, H.Yamaya, H.Tonami, H.Yokoyama:High-MolecularWeight adiponectin inhibits the progression of vascular calcification in Japanese renal allograft recipients, The
Annual of American Society of Nephrology 2016, Chicago, 2016.

0330I005

K.Okino, Y.Okushi, K.Mukai, Y.Matsui, N.Hayashi, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:The LongTerm outcome of hepatitis C viral core Antigen-Positive Japanese renal allograft recipients, The Annual of
American Society of Nephrology 2016, Chicago, 2016.

0330I006

Y.Okushi, K.Okino, K.Mukai, Y.Matsui, N.Hayashi, H.Adachi, H.Yamaya, H.Yokoyama:Circulating and renal
expression of HLA-G prevented renal allograft dysfunction in Japanese recipients, The Annual of American Societyof Nephrology 2016, Chicago, 2016.

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0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Associate Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Assistant Professor

WATANABE Ai

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001

S.Shi, K.Kanasaki, D.Koya:Linagliptin but not sitagliptin inhibited transforming growth factor-β2-induced
endothelial DPP-4 activity and the endothelial-mesenchymal transition., Biochemical and biophysical researchcommunications, 471:1;184-190, 2016.

0340B002(A.Tagawa), M.Yasuda, S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya,
K.Asanuma, EH.Kim, M.Haneda, N.Kajiwara, K.Hayashi, H.Ohashi, S.Ugi, H.Maegawa, T.Uzu:Impaired podocyte
autophagy exacerbates proteinuria in diabetic nephropathy., Diabetes, 65:3;755-767, 2016.

0340B003

K.Nitta, Shi Sen, T.Nagai, M.Kanasaki, M.Kitada, Srivastava Swayam Prakash, M.Haneda, K.Kanasaki,
D.Koya:Oral administration of N-acetyl-seryl-aspartyl-lysyl-proline ameliorates kidney disease in both type 1 andtype 2 diabetic mice via a therapeutic regimen., BioMed research international, 2016:9172157, 2016.

-34-

0340B004

M.Kitada, Y.Ogura, T.Suzuki, S.Sen, S.M.Lee, K.Kanasaki, S.Kume, D.Koya:A very-low-protein diet ameliorates
advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar
fatty rats, an animal model of type 2 diabetes and obesity., Diabetologia, 59:6;1307-1317, 2016.

0340B005

S.P.Srivastava, S.Shi, M.Kanasaki, T.Nagai, M.Kitada, J.He, Y.Nakamura, Y.Ishigaki, K.Kanasaki, D.Koya:Effect of
antifibrotic microRNAs crosstalk on the action of N-acetyl-seryl-aspartyl-lysyl-proline in diabetes-related kidney
fibrosis., Scientific reports, 6:29884, 2016.

0340B006(K.Ueshima), H.Itoh, N.Kanazawa, I.Komuro, R.Nagai, M.Takeuchi, T.Yamazaki, EMPATHY study group, D.Koya,
A.Nakagawa, M.Nishizawa, M.Kitada, S.Tsuda, K.Konishi:Rationale and design of the standard versus intensive
statin therapy for hypercholesterolemic patients with diabetic retinopathy (EMPATHY) study: a randomized
controlled trial, 23:8;976-990, 2016.

0340B007(S.Kume), M.Kondo, S.Maeda, Y.Nishio, T.Yanagimachi, Y.Fujita, M.Haneda, K.Kondo, A.Sekine, S.Araki,
H.Araki, M.Chin-Kanasaki, S.Ugi, D.Koya, S.Kitahara, K.Maeda, A.Kashiwagi, T.Uzu, H.Maegawa:Hypothalamic
AMP-activated protein kinase regulates biphasic insulin secretion from pancreatic β cells during fasting and in
type 2 diabetes, EBioMedicine, 13:168-180, 2016.

0340B008(S.Kuwagata), S.Kume, M.Chin-Kanasaki, H.Araki, S.Araki, J.Nakazawa, T.Sugaya, D.Koya, M.Haneda,
H.Maegawa, T.Uzu:MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2
in proximal tubular cells., Kidney international, 90:6;1211-1225, 2016.

0340B009(T.Uzu), S.Araki, A.Kashiwagi, M.Haneda, D.Koya, H.Yokoyama, Y.Kida, M.Ikebuchi, T.Nakamura, M.Nishimura,
N.Takahara, T.Obata, N.Omichi, K.Sakamoto, R.Shingu, H.Taki, Y.Nagai, H.Tokuda, M.Kitada, M.Misawa,
A.Nishiyama, H.Kobori, H.Maegawa, The Shiga Committee for Preventing Diabetic Nephropathy:Comparative
effects of direct renin inhibitor and angiotensin receptor blocker on albuminuria in hypertensive patients with type2 diabetes. A randomized controlled trial, PLoS ONE, 11:e0164936, 2016.

Reviews
0340C001

K.Kanasaki:The pathological significance of dipeptidyl peptidase-4 in endothelial cell homeostasis and kidney
fibrosis, Diabetology International, 7:3;212-220, 2016.

0340C002(DJ.Klionsky), D.Koya, T.Okazaki et al.:Guidelines for the use and interpretation of assays for monitoring
autophagy (3rd edition)., Autophagy, 12:1;1-222, 2016.

0340C003(A.Takagi), S.Kume, M.Kondo, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya, M.Haneda, T.Chano,
T.Matsusaka, K.Nagao, Y.Adachi, L.Chan, H.Maegawa, T.Uzu:Mammalian autophagy is essential for hepatic andrenal ketogenesis during starvation., Scientific reports, 6:18944, 2016.

0340C004

S.Shi, D.Koya, K.Kanasaki:Dipeptidyl peptidase-4 and kidney fibrosis in diabetes., Fibrogenesis & tissue repair,
9:1, 2016.

0340C005

M.Kitada, Y.Ogura, D.Koya:The protective role of sirt1 in vascular tissue: its relationship to vascular aging andatherosclerosis., Aging(Albany NY), 8:10;2290-2307, 2016.

0340C006

M.Kitada, Y.Ogura, D.Koya:Rodent models of diabetic nephropathy: their utility and limitations., International
journal of nephrology and renovascular disease, 9:279-290, 2016.

Case Reports
0340D001

S.Tsuda, K.Konishi, T.Otoda, T.Nagai, A.Takeda-Watanabe, M.Kanasaki, M.Kitada, A.Nakagawa, M.Nishizawa,
K.Kanasaki, D.Koya:Restoration of the hypothalamic-pituitary-adrenal response to hypoglycemia in type 2
diabetes by avoiding chronic hypoglycemia., Internal medicine, 55:23;3471-3473, 2016.

0340D002 (Y.Sasagawa), O.Tachibana, A.Nakagawa, S.Nakada, T.Nojima, D.Koya, H.Iizuka:Rapid enlargement of an
intracranial germ cell tumor after gonadotropin hormone therapy, JOURNAL OF CLINICAL NEUROSCIENCE,
31:185-188, 2016.

-35-

Short Communications
0340E001

K.Kanasaki:Concerted efforts to combat diabetic complications., Kidney international, 89:2;269-271, 2016.

0340E002

M.Kitada, Y.Ogura, D.Koya:The protective effect of a low-protein diet against tubulo-interstitial damage indiabetic kidneys, Cellular & Molecular Medicine: Open access, 2:2;6-7, 2016.

Presentations at Conference
International Conference (Presentations)
0340I001

O.Tachibana, Y.Sasagawa, A.Nakagawa, D.Koya, Y.Hayashi, M.Nakada, H.Iizuka:Expression of proinflammatory
cytokines and receptors in symptomatic Rathke cleft cysts - a possible mediator of secondary hypophysitis with
Rathke cleft cyst -, Euro-pit and 14th IPPC meeting in Annecy, Lyon, 2016.

0340I002(N.Ueki), S.Takeda, D.Koya, K.Kanasaki:Catechol-O-methyltransferase deficiency leads to hypersensitivity on thepressor response against angiotensin Ⅱ, American Society of Nephrology(KIDNEY WEEK 2016), Chicago, 2016.

0340I003(N.Ueki), A.Itakura, S.Takeda, K.Kanasaki:Catechol-O-methyltransferase deficiency leads to hypersensitivity on
the pressor response against angiotensin Ⅱ, 19th Congress of the Federation of Asia and Oceania Perinatal
Societies (FAOPS 2016), Taipei, 2016.

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0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Senior Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Senior Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Senior Assistant Professor

OGISO Hideo

Hematology and Immunology

Assistant Professor

KAWANAMI Haruka

Hematology and Immunology

Assistant Professor

FUJIMOTO Shino

Hematology and Immunology

Assistant Professor

FURUMOTO Hidehiro Hematology and Immunology

Assistant Professor

HASHIZUME Chieko

Hematology and Immunology

Keywords of Research
Sjogren's syndrome, malignant lymphoma, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, rheumatoid
arthritis, systemic lupus erythematosus, TAFRO syndrome, Cattleman's disease, IgG4-related disease, proteomics, leptin,
follicular dendritic cell,regeneration therapy

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
1, Clinico-pathological study of a new disease entity; TAFRO syndrome.
2, Pathophysiological analysis of IgG4-related disease.
(1) Evaluation of CD14+cells in lymphoid follicle.
(2) Proteomics analysis.
(3) Lipid mediators and those balance .
3, Analysis of Leptin in patients with systemic autoimmune disorders.
4, Evaluation and regeneration therapy of salivary gland tissue in Sjogren's syndrome.
5, Clinical study for patients with intractable aggressive lymphomas.
6, Analysis of iron metabolism in hematological disorders.

Publications
Originals
0350B001

Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara,
H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta,
N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita,
S.Aoki:Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome,2015 version., International journal of hematology, 103:6;686-692, 2016.

-37-

0350B002

Y.Fujita, T.Fujii, H.Shimizu, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka,
Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, T.Mimori:Isolation of vascular smooth muscle antigen-reactive
CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice., Cellular immunology, 303:5054, 2016.

0350B003(K.Kitatani), T.Usui, SK.Sriraman, M.Toyoshima, M.Ishibashi, S.Shigeta, S.Nagase, M.Sakamoto, H.Ogiso,
T.Okazaki, YA.Hannun, VP.Torchilin, N.Yaegashi:Ceramide limits phosphatidylinositol-3-kinase C2β-controlledcell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid, Oncogene, 35:21;28012812, 2016.

0350B004(H.Watanabe), K.Okahara, Y.Naito-Matsui, M.Abe, S.Go, J.Inokuchi, T.Okazaki, T.Kobayashi, Y.Kozutsumi,
S.Oka, H.Takematsu:Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulationof phosphoinositide 4,5-bisphosphate production at the cleavage furrow., Molecular biology of the cell,
27:13;2037-2050, 2016.

0350B005

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki:Proposed diagnostic criteria, disease severity classification, and treatment strategy for a novel
disorder; TAFRO syndrome., The Japanese journal of clinical hematology, 57:10;2029-2037, 2016.

0350B006

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki, Japanese TAFRO syndrome research team:Proposed diagnostic criteria, disease severity
classification, and tretment strategy for a novel disorder;TAFRO syndrome, The Japanese Journal of Clinical
Hematology, 57:10;195-203, 2016.

0350B007

H.Yoshizaki, H.Ogiso, T.Okazaki, E.Kiyokawa:Comparative lipid analysis in the normal and cancerous organoids of
MDCK cells., Journal of Biochemistry, 159:6;573-584, 2016.

0350B008(M.Wu), M.Takemoto, M.Taniguchi, T.Takumi, T.Okazaki, W.J.Song:Regulation of membrane KCNQ1/KCNE1
channel density by sphingomyelin synthase 1, American Journal of Physiology Cell Physiology, 311:C15-C23,
2016.

0350B009

M.Taniguchi, T.Tasaki, H.Ninomiya, Y.Ueda, K.Kuremoto, S.Mitsutake, Y.Igarashi, T.Okazaki,
T.Takegami:Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection withJapanese encephalitis virus, Scientific Reports, 6:37829, 2016.

Reviews
0350C001(DJ.Klionsky), D.Koya, T.Okazaki et al.:Guidelines for the use and interpretation of assays for monitoring
autophagy (3rd edition)., Autophagy, 12:1;1-222, 2016.

0350C002

Y.Masaki:Recent advance of the treatment of IgG4-related disease, Journal of Clinical and Experimental Medicine,258:3;217-222, 2016.

0350C003

Y.Masaki, S.Fujimoto, H.Kawanami(Iwao), T.Sakai, T.Kawanami, Y.Fujita, H.Kawabata, T.Fukushima:How todiagnose and treat IgG4-related disease, Journal of Kanazawa Medical University, 41:67-72, 2016.

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0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Associate Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Associate Professor

SANADA Mitsuru

Clinical neurology, Neurophysiology

Senior Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

FUJITA Michiyo

Clinical neurology

Assistant Professor

OONO Miki

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis,

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(R.Yamasaki),T.Matsushita,T.Fukazawa,K.Yokoyama,K.Fujihara,M.Ogino,T.Yokota,K.Miyamoto,M.Niino,K.Nomur
a,R.Tomioka,M.Tanaka,I.Kawachi,T.Ohashi,K.Kaida,M.Matsui,Y.Nakatsuji,H.Ochi,H.Fukaura,T.Kansa,A.Nagaishi,
K.Togo,H.Mizusawa,H.Murai, J.Kira:Efficacy of intravenous methylprednisolone pulse therapy in patients withmultiple sclerosis and neuromyelitis optica, 22:1337-1348, 2016.

0360B002

S.Nagayama, K.Tanaka:Anti-NMDA Receptor Antibody-Related Encephalitis., Brain and nerve = Shinkei kenkyu
no shinpo, 68:9;1001-1009, 2016.

Reviews
0360C001

M.Sanada, M.Matsui, H.Yasuda:Pathogenesis of diabetic neuropathy, Japanese Journal of Clinical Medicine,
74:223-228, 2016.

Case Reports
0360D001(K.Maeda), H.Kawai, M.Sanada, T.Terashima, N.Ogawa, R.Idehara, T.Makiishi, H.Yasuda, S.Sato, K.Hoshi,
H.Yahikozawa, K.Nishi, Y.Itoh, K.Ogasawara, K.Tomita, H.P.Indo, H.Majima:Clinical phenotype and segregation of
mitochondrial 3243A>G mutation in 2pairs of monozygotic twins, JAMA Neurology, 73:990-993, 2016.

-39-

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Professor

YASUMOTO Kazuo

Gastric cancer, Cancerous peritonitis molecular target therapy

Senior Assistant Professor

HISAMURA Kazuho

Social Work, Social Welfare, Psycho-Oncology

Assistant Professor

KASAI Suguru

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology,

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Reviews
0363C001

Y.Motoo:How long should cancer chemotherapy be continued?-Form the viewpoint of duration of efficacy ofmolecular targeting drugs, Japanese Journal of Cancer and Chemotherapy, 43:7;819-823, 2016.

0363C002 T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto: Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

-40-

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Assistant Professor

USUDA Daisuke

Clinical Infectious Diseases, Infection Control and Prevention

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs,

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001

N.Yoshino, E.Yamada, K.Enda, H.Baba, Y.Iinuma:Fundamental assessment of the chemiluminescent enzyme
immunoassay measurement reagent Lumipulse HBsAg-HQ, Japanese Journal of Medical Technology, 65:1;91-97,
2016.

0366B002(Y.Ito), M.Nagao. Y.Iinuma, Y.Matsumura, M.Yamamoto, S.Takakura, J.Igawa, H.Yamanaka, A.Hashimoto, T.Hirai,
A.Niimi, S.Ichiyama, M.Mishima:Risk factors for nosocomial tuberculosis transmission among health care workers.,
American journal of infection control, 44:5;596-598, 2016.

0366B003(M.Suzuki), K.Yamada, M.Aoki, E.Hosoba, M.Matsumoto, H.Baba, Y.Iinuma:Applying a PCR-based open-reading
frame typing method for easy genotyping and molecular epidemiological analysis of Pseudomonas aeruginosa.,
Journal of applied microbiology, 120:2;487-497, 2016.

0366B004

D.Usuda, R.Sangen, Y.Hashimoto, E.Muranaka, Y.Iinuma, T.Kanda:Validation of a B-type natriuretic peptide as aprognostic marker in pneumonia patients: a prospective cohort study, BMJ open, 6:2;e010440, 2016.

0366B005

M.Taga, D.Usuda, Y.Noda, Y.Iinuma, Y.Nishita, Y.Yamamoto, O.Niwa:Usability by the colorimetric method formeasurement of chlorine concentration in hypochlorite solutions and factors for change of the concentration,
Japanese Journal of Environmental Infections, 31:5;314-317, 2016.

Reviews
0366C001

Y.Iinuma:Management of infectious complications in solid-organ transplant recipients, The Journal of the JapaneseSociety for Clinical Microbiology, 26:1;11-23, 2016.

0366C002

Y.Iinuma:Middle East Respiratory Syndrome(MERS), The Official Journal of Japanese Society of Laboratory
Medicine, 64:9;1044-1051, 2016.

Case Reports
0366D001 D.Usuda, R.Sangen, Y.Iwata, T.Kanda:Interstitial Pneumonia in a 94-Year-Old Woman with MPO-ANCA Positive
Vasculitis, Case Reports in Clinical Medicine, 5:61-65, 2016.

-41-

0366D002

D.Usuda, M.Arahata, R.Temaru, Y.Iinuma, T.Kanda, S.Hayashi:Autopsy-proven intravascular lymphoma
presenting as rapidly recurrent strokes, Case reports in oncology, 9:1;148-153, 2016.

0366D003 K.Nagata, Y.Tanaka, M.Matsumoto, C.Tanaka, K.Nitta, K.Miyazawa, Y.Iinuma: A case of 2,8-dihydroxyadenine
crystal urine that did not show urine calculus, Japanese Journal of Medical Technology, 65:6;695-699, 2016.

Presentations at Conference
International Conference (Presentations)
0366I001

K.Kawamura, Y.Iinuma, D.Usuda, M.Matsumoto, Y.Tanaka, M.Kawano, S.Tateyama, Y.Itose:Evaluation of urine
flow cytometer Sysmex UF-5000:the comparison with routine methods for identifying bacteria, The 32nd World
Congress of Biomedical Laboratory Science, Kobe, 2016.

-42-

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Professor

FURUTA Hisakazu

Sleep-wake disorders

Associate Professor

AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology

Associate Professor

YAMAKAWA Jun-ichi General medicine, Kampo medicine

Associate Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Senior Assistant Professor(Additional Post)

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Books
0368A001

J.Yamakawa, J.Moriya, J.kobayashi:Herbal Medicines:New Horizons, Fating and Kanpo(Japancsc Hebal) Medicines:
Hochuekkito and Juzentaihoto, 97-111, Humana Press, New York, 2016.

Publications
Originals
0368B001

H.Tada, J.Kobayashi, M.Kawashiri, K.Miyashita, A.Nohara, A.Inazu, K.Nakajima, H.Mabuchi,
M.Yamagishi:Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during
three-drug lipid-lowering combination therapy, Lipids in health and disease, 15:66, 2016.

0368B002

R.Tsuda, H.Suzuki:Results of a soccer teaching program intended to help students improve and acquire knowledgeof physical fitness, Japan Journal of Physical Education, Health and Sport Sciences, 61:257-270, 2016.

0368B003

K.Sato, F.Okajima, K.Miyashita, S.Imamura, J.Kobayashi, KL.Stanhope, PJ.Havel, T.Machida, H.Sumino,
M.Murakami, E.Schaefer, K.Nakajima:The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins:
A new definition of remnant lipoproteins, Clinica chimica acta; international journal of clinical chemistry, 461:114125, 2016.

0368B004

M.Sakurai, J.Kobayashi, Y.Takeda, S.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi, H.Nakagawa:Sex Differences in
Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women,
Journal of Epidemiology, 26:8;440-446, 2016.

-43-

Others
0368F001

H.Tada, J.Kobayashi:Optimal management target for Non-high-density lipoprotein cholesterol, Journal of
Atherosclerosis and Thrombosis, 23:4;399-401, 2016.

Presentations at Conference
International Conference (Presentations)
0368I001

R.Tsuda:Load characteristics of soccer games in PE classes from the viewpoint of improvement in physical fitness,
21th annual Congress of the European College of Sport Science (ECSS), Vienna, 2016.

0368I002

J.Kobayashi, K.Miyashita, K,Nakajima:Lipases and the Metabolism of Triglyceride-Rich Lipoproteins, 5thInternational Symposium on Chylomicrons, VLDL, and Remnant Lipoproteins, Boston, 2016.

-44-

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor(Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Associate Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Senior Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

MORITA Takuro

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

OKUNO Tazuo

Geriatrics, Circulation

Assistant Professor

HIMENO Taro

Geriatrics, Circulation

Assistant Professor

HIGASHIKAWA
Toshihiro

Gerontology

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis,

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001(A.Ishiki), S.Okinaga, N.Tomita, R.Kawahara, I.Tsuji, R.Nagatomi, Y.Taki, T.Takahashi, M.Kuzuya, S.Morimoto,K.Iijima, T.Koseki, H.Arai, K.Furukawa:Changes in cognitive functions in the elderly living in temporary housing
after the great east japan earthquake., PLOS ONE, 11:1;1-8, 2016.

0370B002

Y.Hamazaki, Y.Morikawa, S.Morimoto, H.Nakagawa:Difference in the impact of homebound status on functional
decline between independent older men and women: A 2 year follow-up study., Japan journal of nursing science,
13:2;265-272, 2016.

-45-

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITOH Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

FUJIKI Takuma

Pediatric Nephrology

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

OGURI Masato

Pediatric cardiology.

Assistant Professor

IKENO Kanjyu

Child neurology

Assistant Professor

KITTAKA Yuko

Pediatric allergy, Pediatric endocrinology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood,

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001

M.Itoh, Y.Kittaka, Y.Niida, Y.Saikawa:A novel frameshift mutation in the TRPS1 gene caused Tricho-rhinophalangeal syndrome type I and III in a Japanese family, Clinical pediatric endocrinology : case reports and clinicalinvestigations : official journal of the Japanese Society for Pediatric Endocrinology, 25:3;115-118, 2016.

0380B002

Y.Niida, H.Sato, M.Ozaki, M.Itoh, K.Ikeno, E.Takase:Angelman Syndrome Caused by Chromosomal
Rearrangements: A Case Report of 46,XX,+der(13)t(13;15)(q14.1;q12)mat,-15 with an Atypical Phenotype andReview of the Literature, Cytogenetic and genome research, 149:247-257, 2016.

0380B003(M.Shimizu), Y.Saikawa, A.Yachie:Role of 18-fluoro-2-deoxyglucose positron emission tomography in detecting
acute inflammatory lesions of non-bacterial osteitis in patients with a fever of unknown origin: A comparative studyof 18-fluoro-2-deoxyglucose positron emission tomography, bone scan, and magnetic resonance imaging, Modern
rheumatology, 20:1-5, 2016.

-46-

0380B004(T.Kobayashi), S.Fuse, N.Sakamoto, M.Mikami, S.Ogawa, K.Hamaoka, Y.Arakaki, T.Nakamura, H.Nagasawa,
T.Kato, T.Jibiki, S.Iwashima, M.Yamakawa, T.Ohkubo, S.Shimoyama, K.Aso, S.Sato, T.Saji:A New Z Score Curveof the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population., Journalof the American Society of Echocardiography : official publication of the American Society of Echocardiography,
29:8;794-801, 2016.

0380B005(E.Nanishi), T.Hoshina, H.Takada, M.Ishimura, H.Nishio, T.Uehara, Y.Mizuno, S.Hasegawa, S.Ohga, M.Nagao,
M.Igarashi, S.Yajima, Y.Kusumoto, N.Onishi, Y.Sasahara, T.Yasumi, T.Heike, T.Hara, PID-Infection Study
Group:A nationwide survey of common viral infections in childhood among patients with primary immunodeficiency
diseases, Journal of Infection, 73:358-368, 2016.

Case Reports
0380D001

K.Ishimaru, K.Araki, T.Nakamura, Y.Sawa:An alternative technique for direct implantation of an anomalous left
coronary artery arising from the pulmonary artery with complex coronary arteries., Journal of surgical case reports,
9:1-3, 2016.

0380D002

R.Fujisawa, T.Nakamura, K.Ishimaru, S.Toki, G.Ko, C.Akita, T.Nakamura, H.Sato, T.Kuwahara, M.Kohno,
Y.Saikawa:Painless bloody stool due to a Meckel diverticulum in infant : a case report, Japanese Journal of
Pediatrics, 69:10;1651-1655, 2016.

Presentations at Conference
International Conference (Presentations)
0380I001

M.Ozaki, Y.Niida, E.Takase, Y.Ito, H.Sato, T.Ikeda:Visualization of Cytogenetic Testing in Clinical Genetics, 13th
International Congress of Human Genetics, Kyoto, 2016.

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0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Associate Professor

UEHARA Takashi

Neuropharmacology

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Assistant Professor

NITTA Yusuke

Consultation liaison psychiatry

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Assistant Professor

KIHARA Hiroaki

Brain imaging, Schizophrenia

Assistant Professor

SHIMADA Takamitsu Brain imaging, Schizophrenia

Assistant Professor

OHI Kazutaka

Psychiatry, Genetics, Neuropsychopharmacology, BiologicalPsychiatry, Imaging

Assistant Professor

OKUBO Hiroaki

Psychiatry, Neurophysiology

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging, rTMS

Outline of Research
1.Study on regional identification of brain language areas by functional MRI―application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia
8.Study on repetitive transcranial magnetic stumilation for depression

Publications
Originals
0390B001

K.Ohi, T.Shimada, Y.Nitta, H.Kihara, H.Okubo, T.Uehara, Y.Kawasaki:Specific gene expression patterns of 108
schizophrenia-associated loci in cortex, Schizophrenia research, 174:1-3;35-38, 2016.

0390B002

K.Ohi, T.Shimada, Y.Nitta, H.Kihara, H.Okubo, T.Uehara, Y.Kawasaki:The Five-Factor Model personality traits
in schizophrenia: A meta-analysis., Psychiatry research, 240:34-41, 2016.

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0390B003(N.Okada), M.Fukunaga, F.Yamashita, D.Koshiyama, H.Yamamori, K.Ohi, Y.Yasuda, M.Fujimoto, Y.Watanabe,
N.Yahata, K.Nemoto, Hibar D P, van Erp T G M, H.Fujino, M.Isobe, S.Isomura, T.Natsubori, H.Narita,
N.Hashimoto, J.Miyata, S.Koike, T.Takahashi, H.Yamasue, K.Matsuo, T.Onitsuka, T.Iidaka, Y.Kawasaki,
R.Yoshimura, Y.Watanabe, M.Suzuki, Turner J A, M.Takeda, Thompson P M, N.Ozaki, K.Kasai,
R.Hashimoto:Abnormal asymmetries in subcortical brain volume in schizophrenia., Molecular psychiatry,
21:10;1460-1466, 2016.

0390B004(K.Uno), Y.Kikuchi, M.Iwata, T.Uehara, T.Matsuoka, T.Sumiyoshi, Y.Okamoto, H.Jinno, T.Takada, Y.FurukawaHibi, T.Nabeshima, Y.Miyamoto, A.Nitta:Decreased DNA Methylation in the Shati/Nat8l Promoter in Both
Patients with Schizophrenia and a Methamphetamine-Induced Murine Model of Schizophrenia-Like Phenotype,
PloS one, 11:6;e0157959, 2016.

0390B005(L.Huang), K.Ohi, H.Chang, H.Yu, L.Wu, W.Yue, D.Zhang, L.Gao, M.Li:A comprehensive meta-analysis of
ZNF804A SNPs in the risk of schizophrenia among Asian populations, American Journal of Medical Genetics B
Neuropsychiatric Genetics, 171:3;437-446, 2016.

0390B006

K.Ohi, Y.Matsuda, T.Shimada, T.Yasuyama, K.Oshima, K.Sawai, H. Kihara, Y.Nitta, H.Okubo, T.Uehara,
Y.Kawasaki:Structural alterations of the superior temporal gyrus in chizophrenia: Detailed subregional differences,
European Psychiatry, 35:25-31, 2016.

0390B007

Y.Matsuda, H.Kihara, K.watanabe, Y.Kawasaki:A computer-aided diagnosis method using spatial and temporalcharacteristics of near-infrared spectroscopy data in major depressive disorder and bipolar disorder(2), IEICE:2328, 2016.

0390B008

H.Okubo:Near-infrared spectroscopy analysis of the effect of Repetitive transcranial magnetic stimulation in
depression, Journal of Kanazawa Medical University, 41:10-17, 2016.

0390B009(S.Yoneyama), Y.Makita, K.Miyazu, K.Katsukawa, E.Yoneyama, S.Masuda, Y.Nakajima, Y.Kawasaki, K.Miyazu:The
Role of Family Variables in the Length of Stay of Psychiatric In-patients, Clinical practice and epidemiology inmental health, 12:87-93, 2016.

Case Reports
0390D001

H.Kihara, Y.Matsuda, Y.Toshiki, H.Okubo, R.Hashimoto, K.Watanabe, Y.Kawasaki:Reliability of repeated optical
topography test date in patients with major depression disorder:An investigation of near-infrared spectroscopy
date of successive sessions, Journal of Kanazawa Medical University, 41:1;18-24, 2016.

Short Communications
0390E001

K.Ohi, M.Kikuchi, M.Ikeda, H.Yamamori, Y.Yasuda, M.Fujimoto, H.Fujino, K.Miura, M.Fukunaga, A.Nakaya,
N.Iwata, R.Hashimoto:Polygenetic components for schizophrenia, bipolar disorder and rheumatoid arthritis predictrisk of schizophrenia, Schizophrenia research, 175:1-3;437-446, 2016.

0390E002

K.Ohi, T.Shimada, Y.Nitta, H.Kihara, H.Okubo, T.Uehara, Y.Kawasaki:Schizophrenia risk variants in ITIH4 and
CALN1 regulate gene expression in the dorsolateral prefrontal cortex, Psychiatric Genetics, 26:142-143, 2016.

Presentations at Conference
International Conference (Presentations)
0390I001

Y.Matsuda, R.Hashimoto, S.Takemoto, M.Ishizaki, Y.Kawasaki:A Dementia Screening Investigation for Inhabitantsof Rural Areas in Japan, The 2016 Alzheimer's Disease Congress, London, 2016.

0390I002

Y.Kawasaki, R.Hashimoto, S.Takemoto, T.Shimada, H.Kihara, K.Ohi, T.Uehara, Y.Matsuda,
M.Tunoda.:Establishment of a clinical service for young people at risk of developing psychosis in Uchinada Japan.,
IEPA10, Milan, 2016.

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0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging、Radiation therapy

Professor

WATANABE Naoto

Nuclear Medicine

Senior Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

OTA Kiyotaka

Assistant Professor

KITADATE Masataka Interventional Radiology, Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Diagnostic Imaging

Assistant Professor

TSUCHIYA Naoko

Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

OISO Kazumasa

Diagnostic Imaging

Assistant Professor

NAKAJIMA Kento

Diagnostic Imaging

Radiation Therapy，Nuclear Medicine

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjogren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium,

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

N.Watanabe, K.Yokoyama, S.Kinuya, H.Tonami:Evaluation of cytological radiation damage to lymphocytes after I131 metaiodobenzylguanidine therapy by the cytokinesis-blocked micronucleus assay., Annals of nuclear medicine.,
30:9;624-628, 2016.

0400B002(K.Higashi), T.Yamagishi, Y.Ueda, Y.Ishigaki, M.Shimasaki, Y.Nakamura, M.Oguchi, T.Takegami, M.Sagawa,
H.Tonami:Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma., Annals of
nuclear medicine, 30:10;708-715, 2016.

0400B003

H.Adachi, K.Nakayama, N.Hayashi, Y.Matsui, K.Fujimoto, H.Yamaya, H.Tonami, H.Yokoyama:Adiponectin
Fractions Influence the Development of Posttransplant Diabetes Mellitus and Cardiovascular Disease in Japanese
Renal Transplant Recipients, PLoS one, 11:10;e0163899, 2016.

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0400B004

K.Usuda, M.Sagawa, S.Maeda, N.Motono, M.Tanaka, Y.Machida, M.Matoba, T.Matsui, N.Watanabe, H.Tonami,
Y.Ueda, H.Uramoto:Diagnostic performance of whole-body diffusion-weighted imaging compared to PET-CT plus
brain MRI in staging clinically resectable lung cancer, Asian Pacific journal of cancer prevention : APJCP,
17:6;2775-2780, 2016.

0400B005

N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, H.Toga, M.Matoba, M.Sagawa:The therapeutic strategy forclinical stage IA non-small cell lung cancer patients who are ineligible for lobectomy, Haigan, 56:3;183-188, 2016.

0400B006

I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, T.Ishii, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Ota, M.Matoba,
K.Miyazawa: The effect of radiation therapy for bone metastasis in urinary organ cancer, Japanese Journal of
Urology, 107:1;7-12, 2016.

Case Reports
0400D001

T.Takahashi, N.Watanabe, M.Wakasa, K.Kajinami, H.Tonami:18F-FDG PET/CT for Detecting Sarcoma of the
Aorta in a Patient with Takayasu Arteritis, Nuclear medicine and molecular imaging, 50:2;171-172, 2016.

0400D002 Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, M.Matoba,
K.Sato,and K.Miyazawa: A case of renal cell carcinoma metastasized to gluteal muscle after partial nephrectomy,
Japanese Journal of Urological Surgery, 29:2;177-180, 2016.

Presentations at Conference
International Conference (Presentations)
0400I001

Y.Nakano, M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDGPET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th Annual
Asian Oncology Summit, 12th Annual Conference of the OOTR and Kyoto Breast Cancer Consensus Conference
2016, Kyoto, 2016.

0400I002

M.Doai, N.Tsuchiya, H.Tonami:Histogram analysis of apparent diffusion coefficient for non-small cell lungcancer:correlation with pathological grade, International Society for Magnetic Resonance in Medicine 24th Annual
Meeting and Exhibition 2016, Singapore, 2016.

0400I003

M.Doai, H.Tonami, O.Tachibana:Utility of Histogram Analysis of Apparent Diffusion Coeffisient Value forDistinguishing Pituitary Atypical Adenomas from Typical Adenomas, International Society for Magnetic Resonancein Medicine 24th Annual Meeting and Exhibition 2016, Singapore, 2016.

0400I004

H.Adachi, K.Nakayama, N.Hayashi, Y.Matsui, K.Fujimoto, H.Yamaya, H.Tonami, H.Yokoyama:High-MolecularWeight adiponectin inhibits the progression of vascular calcification in Japanese renal allograft recipients, The
Annual of American Society of Nephrology 2016, Chicago, 2016.

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0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

SHIKATA Hiroo

Vascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Associate Professor

ISHIMARU KazuhikoPediatric Cardiac Surgery

Associate Professor

NAGAYOSHI Yasuhiro Cardiovascular surgery

Senior Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Senior Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Assistant Professor

TANAKA Hirokazu

Cardiovascular surgery, Vascular surgery

Assistant Professor

TSUCHIYA Hirokazu Cardiovascular surgery, Vascular surgery

Assistant Professor

ARAKI Kanta

Pediatric Cardiac Surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer,

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of patient-specific cardiac supporting net for dilated heart failure patients
3.Endovascular stent-grafting for aortic aneurysm

Publications
Originals
0410B001

M.Okada, T.Akita, F.Mizuno, A.Nakayama, K.Morioka:Benefit effects of cardiac support device on left ventricularremodeling after posterior myocardial infarction: an evaluation by echocardiography, pressure-volume curves andventricular histology, Surgery Today, 46:5;621-630, 2016.

Case Reports
0410D001

K.Ishimaru, K.Araki, T.Nakamura, Y.Sawa:An alternative technique for direct implantation of an anomalous left
coronary artery arising from the pulmonary artery with complex coronary arteries., Journal of surgical case reports,
9:1-3, 2016.

0410D002 R.Fujisawa, T.Nakamura, K.Ishimaru, S.Toki, G.Ko, C.Akita, T.Nakamura, H.Sato, T.Kuwahara, M.Kohno,
Y.Saikawa: Painless bloody stool due to a Meckel diverticulum in infant : a case report, Japanese Journal of
Pediatrics, 69:10;1651-1655, 2016.

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0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

URAMOTO Hidetaka

Professor

USUDA Katsuo

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MATSUI Takuma

thoracic surgery, lung cancer

FacultyThoracic Surgery, Video assisted thoracoscopic surgery, Lung
Cancerthoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy-53-

Publications
Originals
0415B001

H.Uramoto, Y.Nakajima, H.Kinoshita:Is the isolated pericardial fat pad sufficient to cover the bronchial stump andseparate the pulmonary artery in order to prevent bronchopleural fistula in patients with lung cancer?, Anticancer
research, 36:5;2385-2390, 2016.

0415B002(Y.Nakajima), Y.Iijima, H.Uramoto:The difference in bronchial patency between the sweet and modified overfolt
methods at a deep site: current strategies are based on previous knowledge, Anticancer research, 36:6;2729-2731,
2016.

0415B003

H.Uramoto, Y.Nakajima, H.Kinoshita, H.Akiyama:Equivalent outcome of patients with locally advanced NSCLC
treated with salvage surgery compared to Induction chemotherapy followed by surgical resection, Anticancer
research, 36:8;4243-4247, 2016.

0415B004

H.Uramoto, Y.Iijima, Y.Nakajima, H.Kinoshita:Accurate Diagnosis of Aortic Invasion in Patients with Lung
Cancer., Anticancer research, 36:5;2391-2395, 2016.

0415B005

N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, H.Toga, M.Matoba, M.Sagawa:The therapeutic strategy forclinical stage IA non-small cell lung cancer patients who are ineligible for lobectomy, Haigan, 56:3;183-188, 2016.

0415B006

K.Usuda, M.Sagawa, S.Maeda, N.Motono, M.Tanaka, Y.Machida, M.Matoba, T.Matsui, N.Watanabe, H.Tonami,
Y.Ueda, H.Uramoto:Diagnostic performance of whole-body diffusion-weighted imaging compared to PET-CT plus
brain MRI in staging clinically resectable lung cancer, Asian Pacific journal of cancer prevention : APJCP,
17:6;2775-2780, 2016.

0415B007

Y.Machida, M.Sagawa, M.Tanaka, N.Motono, T.Matsui, K.Usuda, H.Uramoto:Postoperative survival according to
the glasgow prognostic score in patients with resected lung adenocarcinoma, Asian Pacific journal of cancer
prevention : APJCP, 17:10;4677-4680, 2016.

0415B008(Y.Iijima), H.Akiyama, M.Atari, M.Fukuhara, Y.Nakajima, H.Kinosita, H.Uramoto:Pulmonary resection formetastatic gastric cancer, Annals of Thoracic and Cardiovascular Surgery, 27:1-7, 2016.

0415B009

K.Usuda, S.Maeda, N.Motono, M.Tanaka, M.Ueno, Y.Machida, M.Sagawa, H.Uramoto:Pulmonary Function After
Lobectomy: Video-Assisted Thoracoscopic Surgery Versus Muscle-Sparing Mini-thoracotomy., Indian Journal ofSurgery, 1:1-6, 2016.

0415B010

N.Motono, S.Maeda, R.Honda, M.Tanaka, Y.Machida, K.Usuda, M.Sagawa, H.Uramoto:Atmospheric temperatureand pressure influence the onset of spontaneous pneumothorax, The clinical respiratory journal, 17:1-6, 2016.

Case Reports
0415D001(Y.Iijima), H.Akiyama, Y.Nakajima, H.Kinoshita, M.Iwao, H.Uramoto, T.Harita:Solitary lung metastasis fromgestational choriocarcinoma resected six years after hydatidiform mole: A case report., International journal ofsurgery case reports, 28:231-233, 2016.

0415D002

H.Uramoto, Y.Nakajima, H.Kinoshita:Left upper lobe double sleeve lobectomy with double barrel anastomosis forlung adenocarcinoma., Annals of medicine and surgery (2012), 9:12-14, 2016.

0415D003

N.Motomo, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, M.Sagawa:Successful treatment of bronchopleural fistula byendoscopic submucosal injection of polidocanol, The Journal of the Japan Sociely for Respiratory Endoscopy,
38:319-323, 2016.

0415D004(S.Oka), H. Matsumiya, S. Shinohara, T.Kuwata, M. Takenaka, Y.o Chikaishi, A.Hirai, N. Imanishi, K.Kuroda, H.
Uramoto, E. Nakamura, F. Tanaka:Total vertebrectomy(Th2) and dissection of the subclavian artery for a superiorsulcus tumor invading the spine: A case report, International journal of surgery case reports, 1:1-4, 2016.

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Short Communications
0415E001

N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, Y.Tomita, T.Kosaka, M.Sagawa:A case of empyema and aposterior mediastinal abscess after an iliopsoas abscess secondary to crohn's disease, International journal ofcolorectal disease, 31:3;709-710, 2016.

Presentations at Conference
International Conference (Presentations)
0415I001

Y.Machida, Y.Ueda, M.Shimazaki, M.Tanaka, N.Motono, T.Matsui, K.Usuda, H.Uramoto:Analysis of postoperative
survival in patients with resected lung adenocarcinoma according to the tumor-associated macrophages., American
Thoracic Society 2016, San Francisco, 2016.

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0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUJITA Hideto

Surgical treatment of gastric cancer,

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

MORIOKA Emi

Surgery of Digestive Diseases

Assistant Professor

FUJITA Jun

Surgery of Digestive Diseases

Assistant Professor

MIURA Seiko

Assistant Professor

FUJII Yoritaka

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics,

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Books
0420A001

S.Kinami:Function-Preserving Curative Gastrecomy Guided by ICG Fluorescence Imaging for Early Gastric
Cancer, ICG Fluorescence Imaging and Navigation Surgery, 151-161, Springer, Japan, 2016.

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Publications
Originals
0420B001

M.Noguchi, M.Noguchi, Y.Ohno, E.Morioka, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Feasibility study of axillary
reverse mapping for patients with clinically node-negative breast cancer., European journal of surgical oncology,
42:5;650-656, 2016.

0420B002

S.Kinami, T.Ohnishi, J.Fujita, Y.Tomita, G.Funaki, H.Fujita, Y.Nakano, N.Ueda, T.Kosaka:Optimal settings andaccuracy of indocyanine green fluorescence imaging for sentinel node biopsy in early gastric cancer., Oncology
letters, 11:6;4055-4062, 2016.

0420B003

S.Kinami, H.Funaki, H.Fujita, Y.Nakano, N.Ueda, T.Kosaka:Local resection of the stomach for gastric cancer.,
Surgery today, 47:6;651-659, 2016.

0420B004(K.Oyama), S.Fushida, M.Kaji, T.Takeda, K.Yabushita, H.Nezuka, S.Kinami, N.Kadoya, Y.Takai, Y.Tsukioka,
S.Ohyama, K.Tsuji, T.Tsukada, J.Kinoshita, T.Fujimura, T.Ohta:Evaluation of the efficacy of palonosetron forprevention of chemotherapy-induced nausea and vomitting in patients with gastric cancer treated with S-1 plus
cisplatin, International journal of clinical oncology, 21:3;483-490, 2016.

0420B005(K.Nakada), M.Takahashi, M.Ikeda, S.Kinami, M.Yoshida, Y.Uenosono, Y.Kawashima, S.Nakao, A.Oshio,
Y.Suzukamo, M.Terashima, Y.Kodera:Factors affecting the quality of life of patients after gastrectomy as assessedusing the newly developed PGSAS-45 scale: A nationwide multi-institutional study, World journal ofgastroenterology, 22:40;8978-8990, 2016.

Reviews
0420C001

M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, Y.Nakano, T.Kosaka, T.Kurita:Oncoplastiic breast conserving surgery:
Volume replacement vs. volume displacement., European journal of surgical oncology, 42:7;926-934, 2016.

Case Reports
0420D001

T.Onishi, N.Ueda, S.Miura, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, S.Nakada:A case of invasive
cholangiocarcinoma with diffuse biliary intraepithelial neoplasia, Journal of Japan Biliary Association, 30:4;741-748,
2016.

0420D002

N.Ueda, Y.Fujii, S.Miura, J.Fujita, D.Kaida, Y.Tomita, T.Onishi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano,
T.Kosaka:Radical resection of cT3a gallbladder cancer after neoadjuvant chemotherapy - A case report, Japanese
Journal of Cancer and Chemotherapy, 43:12;1597-1599, 2016.

0420D003

S.Miura, N.Ueda, S.Kinami, T.Kosaka, H.Funaki, N.Sakata, R.Nishino, W.Koda:Remission of advanced gastriccancer with concurrent portal vein tumor thrombosis via chemotherapy - A cace report, Japanese Journal ofCancer and Chemotherapy, 43:12;1911-1913, 2016.

0420D004

S.Miura, Y.Oikawa, N.Ueda, M.Murakami, N.Sakata:Case of viper (Glodius blomhoffii) bites treated withhospitalization in the Ishikawa Prefecture, Noto district, Clinical Parasitology, 27:1;75-77, 2016.

Short Communications
0420E001

N.Motono, M.Tanaka, Y.Machida, S.Maeda, K.Usuda, Y.Tomita, T.Kosaka, M.Sagawa:A case of empyema and aposterior mediastinal abscess after an iliopsoas abscess secondary to crohn's disease, International journal ofcolorectal disease, 31:3;709-710, 2016.

Others
0420F001

M.Noguchi, S.Miura, E.Morioka, Y.Ono, M.Noguchi, Y.Nakano, T.Kosaka:Reply to: "Is there a role for axillary
reverse mapping in the current management of breast cancer treatment?", European journal of surgical oncology,
42:1;153-154, 2016.

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0420F002

S.Kinami:Perspective of new techniques overcoming laparoscopic sentinel node biopsy for early gastric cancer,
Translational gastroenterology and hepatology, 1:64, 2016.

0420F003

H.Funaki, Y.Fujii, S.Miura, J/Fujita, E.MOrioka, D.Kaida, T.Onishi, Y.Tomita, M.Noguchi, H.Fujita, S.Kinami,
Y.Nakano, N.Ueda, T.Kosaka:Treatment outcomes of advanced gastric cancer after neoadjuvant chemotherapy
with S-1 and cisplatin, Japanese Journal of Cancer and Chemotherapy, 43:12;1421-1423, 2016.

Presentations at Conference
International Conference (Presentations)
0420I001

Y.Nakano, M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of 18F-FDGPET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th Annual
Asian Oncology Summit, 12th Annual Conference of the OOTR and Kyoto Breast Cancer Consensus Conference
2016, Kyoto, 2016.

0420I002

Y.Ohno, M.Noguchi, E.Morioka, M.Noguchi, Y.Nakano, T.Kosaka, H.Minato:Tangenitial frozen section analysis forthe surgical margins in breast-conserving surgery, 8th Annual Asian Oncology Summit, 12th Annual Conference of
the OOTR and Kyoto Breast Cancer Consensus Conference 2016, Kyoto, 2016.

0420I003

S.Kinami, T.Onishi, Y.Fujii, J.Fujita, D.Kaida, Y.Tomita, H.Fujita, Y.Nakano, N.Ueda, T.Kosaka:The applicationof ICG fluorescence sentinel node biopsy for early gastric cancer to the laparoscopic function preserving
gastrectomy, ISNS 2016 Biannual Meeting, Milan, 2016.

0420I004

H.Kitakata, T.Itoh, S.Kinami, S.Azukisawa, R.Kobayashi, K.Hamada, K.Kawaura, T.Kosaka:A clinical study ofendoscopic full-thick-ness resection by serosa sealing method for submucosal invasive gastric cancer without
sentinel node metastasis., UEGW2016, Venue, 2016.

0420I005

S.Miura, N.Ueda, S.Kinami, Y.Fujii, J Fujita, D.Kaida, T.Onishi, Y.Tomita, H.Fujita, Y.Nakano,
T.Kosaka:Gastrointestinal decompression by venting ercutaneous endoscopic gastrostomy: symptomatic relief ofend-stage malignancies - case report, 40th World Congress of the International College of Surgeons / 62nd
Annual Congress of the International College of Surgeons Japan Section, Kyoto, 2016.

0420I006

S.Kinami, S.Miura, T.Onishi, Y.Tomita, H.Fujita, Y.Nakano, N.Ueda, T.Kosaka:Effect of surgical procedures,adjuvant chemotherapy and complications on prognosis following resection of advanced gastric cancer, 40th World
Congress of the International College of Surgeons / 62nd Annual Congress of the International College of Surgeons
Japan Section, Kyoto, 2016.

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0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAHARA Norio

Spinal surgery

Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Professor

MATSUMOTO Tadami Hip surgery

Associate Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Associate Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Senior Assistant Professor

FUKUI Kiyokazu

Hip surgery

Senior Assistant Professor

HIROMURA Kentaro

TraumaSenior Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

ORITA Yugo

Spinal surgery, orthopaedic surgery

Assistant Professor

TAKAHASHI Eiji

Hip surgery

Assistant Professor

TAGUCHI Keita

orthopaedic surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Assistant Professor

HATANO Eiju

Spinal surgery

Assistant Professor

SHIMIZU Yoshiaki

Spinal surgery

Assistant Professor

UEDA Shusuke

Hip surgery

Assistant Professor

TSUDA Ryoji

Hip surgery

Assistant Professor

SOMA Daisuke

orthopadeic Surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, implant coating.

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we perform a study to make antibacterial implant to prevent SSI. We confirmed that fluoride added DLC
coating does not have cytotoxicity, and its bactericidal effect for staphylococcus aureus and E.coli. We are going tocontinue this study for manufacture.

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Publications
Originals
0430B001(MG.Fehlings), A.Nater, JJ.Zamorano, LA.Tetreault, PP.Varga, ZL.Gokaslan, S.Boriani, CG.Fisher, L.Rhines,
C.Bettegowda, N.Kawahara, D.Chou:Risk factors for recurrence of surgically treated conventional spinal
schwannomas: Analysis of 169 patients from a multicenter international database., Spine, 41:5;390-398, 2016.

0430B002

K.Fukui, A.Kaneuji, T.Matsumoto, K.Shintani:Squeaking and microcracks in a delta-delta ceramic coupling: pinon-disc study., European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 26:3;299-304,
2016.

0430B003(S.Kato), H.Murakami, S.Demura, K.Nambu, Y.Fujimaki, K.Yoshioka, N.Kawahara, K.Tomita, H.Tsuchiya:Spinal
metastasectomy of renal cell carcinoma: A 16-year single center experience with a minimum 3-year follow-up.,
Journal of surgical oncology, 113:5;587-592, 2016.

0430B004(ZL.Gokaslan), PL.Zadnik, DM.Sciubba, N.Germscheid, CR.Goodwin, JP.Wolinsky, C.Bettegowda, ML.Groves,
A.Luzzati, LD.Rhines, CG.Fisher, PP.Varga, MB.Dekutoski, MJ.Clarke, MG.Fehlings, NA.Quraishi, D.Chou,
JJ.Reynolds, RP.Williams, N.Kawahara, S.Boriani:Mobile spine chordoma: results of 166 patients from the AOSpine
Knowledge Forum Tumor database, Journal of neurosurgery. Spine, 24:644-651, 2016.

0430B005(D.Choi), Z.Fox, T.Albert, M.Arts, L.Balabaud, C.Bunger, JM.Buchowski, MH.Coppes, B.Depreitere,
MG.Fehlings, J.Harrop, N.Kawahara, JA.Martin-Benlloch, EM.Massicotte, C.Mazel, FC.Oner, W.Peul,
N.Quraishi, Y.Tokuhashi, K.Tomita, JJ.Verlaan, M.Wang, M.Wang, HA.Crockard:Rapid improvements in pain andquality of life are sustained after surgery for spinal metastases in a large prospective cohort., British journal ofneurosurgery, 30:3;337-344, 2016.

0430B006

R.Tsuda:Differences in mechanical behavior between cobalt–chromium alloy and stainless-steel alloy in polishedtapered femoral stems fixed with bone cement, Journal of Kanazawa Medical University, 41:1;1-9, 2016.

0430B007

S.Ueda, T.Ichiseki, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:The timing of glucocorticoid-induced osteocytic
cell necrosis under hypoxia, International journal of clinical and experimental pathology, 9:7;7470-7475, 2016.

0430B008(S.Ohfuji), S.Jingushi, K.Kondo, M.Sofue, M.Itoman, T.Matsumoto, Y.Hamada, H.Shindo, Y.Takatori, H.Yamada,
Y.Yasunaga, H.Ito, S.Mori, I.Owan, G.Fujii, H.Ohashi, S.Takahashi, Y.Hirota:Factors associated with diagnostic
stage of hip osteoarthritis due to acetabular dysplasia among Japanese female patients: a cross-sectional study.,
BMC musculoskeletal disorders, 17:320, 2016.

0430B009(Y.Takegami), T.Seki, A.Kaneuji, A.Nakao, Y.Hasegawa, N.Ishiguro:Validity of a tablet computer version of theJapanese Orthopaedic Association hip disease evaluation questionnaire: a pilot study., Nagoya journal of medical
science, 78:3;237-244, 2016.

0430B010(JJ.Verlaan), D.Choi, A.Versteeg, T.Albert, M.Arts, L.Balabaud, C.Bunger, JM.Buchowski, CK.Chung,
MH.Coppes, HA.Crockard, B.Depreitere, MG.Fehlings, J.Harrop, N.Kawahara, ES.Kim, CS.Lee, Y.Leung, Z,Liu,
A.Martin-Benlloch, EM.Massicotte, C.Mazel, B.Meyer, W.Peul, NA.Quraishi, Y.Tokuhashi, K .Tomita,
C.Ulbricht, M.Wang, FC.Oner:Characteristics of patients who survived < 3 months or > 2 years after surgery for
spinal metastases: can we avoid inappropriate patient selection?, Journal of clinical oncology : official journal of theAmerican Society of Clinical Oncology, 34:25;3054-3061, 2016.

0430B011

N.Takano, A.Kaneuji:Effect of contact conditions on stress analysis of hip prosthesis by FEM．, Japanese Journalof Clinical Biomechanics, 37:281-285, 2016.

0430B012(K.Shintani), T.Kobayashi, H.Nakai, M.Kawaguchi, K.Yonezawa, N.Kawahara:Effect of DLC coating of 3D－
honeycomb form scaffolding on osteoconduction, Japanese Journal of Clinical Biomechanics, 37:35-41, 2016.

0430B013

K.Fukui, A.Kaneuji, S.Ueda, T.Matsumoto:Should well-fixed uncemented femoral components be revised in
infected hip arthroplasty? Report of five trial cases., Journal of orthopaedics, 13:4;437-442, 2016.

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Reviews
0430C001(R.Charest-Morin), S.Boriani, CG.Fisher, SR.Patel, N.Kawahara, E.Mendel, C.Bettegowda, LD.Rhines:Benign
tumors of the spine: has new chemotherapy and interventional radiology changed the treatment paradigm?, Spine,
41:20;S178-S185, 2016.

0430C002(J.Reynolds), R.Khundkar, S.Boriani, R.Williams, LD.Rhines, N.Kawahara, JP.Wolinsky, ZL.Gokaslan,
PP.Varga:Soft tissue and bone defect management in total sacrectomy for primary sacral tumors: a systematic
review with expert recommendations., Spine, 41:20;S199-S204, 2016.

0430C003(T.Ailon), R.Torabi, CG.Fisher, LD.Rhines, MJ.Clarke, C.Bettegowda, S.Boriani, YJ.Yamada, N.Kawahara,
PP.Varga, JH.Shin, A.Saghal, ZL.Gokaslan:Management of locally recurrent chordoma of the mobile spine andsacrum: a systematic review., Spine, 41:20;S193-S198, 2016.

Case Reports
0430D001

K.Fukui, A.Kaneuji, T.Matsumoto:Arthroscopic correction for concomitant cam impingement in a patient with
idiopathic osteonecrosis of the femoral head: A case report., International journal of surgery case reports, 19:154158, 2016.

0430D002(A.Takeuchi), N.Yamamoto, K.Hayashi, S.Miwa, M.Takahira, K.Fukui, T.Oikawa, H.Tsuchiya:Tenosynovial giant
cell tumors in unusual locations detected by positron emission tomography imaging confused with malignant
tumors: report of two cases., BMC musculoskeletal disorders, 17:180, 2016.

0430D003

Y.Numata, T.Okuda, Y.Tachi, T.Matsumoto, M.Fujiwara:A case of fracture of the hook of the hamate bone in ayouth water polo player, JOSKAS, 41:3;1075-1078, 2016.

Presentations at Conference
International Conference (Symposium)
0430H001

N.Kawahara:The role of en bloc surgical resection in the treatment of metastatic tumors of the spine, 5th BolognaBudapest-Basel Spine Meeting -AOSpine Symposium- Knowledge Forum Tumor: An Update, Basel, 2016.

International Conference (Presentations)
0430I001

K.Fukui, A.Kaneuji, T.Matsumoto:Inversion of the acetabular labrum triggers rapidly destructive osteoarthritis of
the hip, ORS 2016 Annual Meeting (Orthopaedic Research Society), Orlando, 2016.

0430I002

K.Fukui, K.Briggs, C.Trindade, M.Philippon:Labral repair and treatment of impingement in borderline dysplastic
patients with femoroacetabular impingement, AAOS 2016 Annual Meeting (American Academy of Orthopaedic
Surgeons), Orlando, 2016.

0430I003

T.Sugimori, A.Kaneuji, Y.Tachi, R.Tsuda, T.Matsumoto:Intraoperative evaluation of PCL elasticity using a newdevise in cruciate-retaining total knee arthroplasty, 17th EFORT Congress (European Federation of National
Associations of Orthopaedics and Traumatology), Geneva, 2016.

0430I004

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:A minimum ten-year result for cementless
acetabular components fixed by “Line To Line Technique” in developmental dysplasia of the hip, 17th EFORT
Congress (European Federation of National Associations of Orthopaedics and Traumatology), Geneva, 2016.

0430I005

K.Fukui, A.Kaneuji, N.Kawahara, T.Matsumoto:Catastrophic failure after endoscopic shelf acetabuloplasty formoderate acetabular dysplasia, ISHA 2016 (International Society for Hip Arthroscopy), San Francisco, 2016.

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0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Professor

TAKADA Hisashi

cerebrovascular disease，endovascular therapy

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Senior Assistant Professor

SIRAGA Syunsuke

cerebrovascular disease

Assistant Professor

TORIGOE Keiichiro

general neurosurgery

Assistant Professor

SHOJIMA Hirotaka

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis-62-

Publications
Originals
0440B001(Y.Hayashi), D.Kita, M.Iwato, I.Fukui, Y.Sasagawa, M.Oishi, O.Tachibana, M.Nakada:Midline dural filum of thesellar floor: Its relationship to the septum attachment to the sellar floor and the ossification in the sphenoid sinus.,
Clinical neurology and neurosurgery, 147:53-58, 2016.

0440B002(Y.Hayashi), D.Kita, T.Watanabe, I.Fukui, Y.Sasagawa , M.Oishi, O.Tachibana, F.Ueda, M.Nakada:Prediction of
postoperative diabetes insipidus using morphological hyperintensity patterns in the pituitary stalk on magnetic
resonance imaging after transsphenoidal surgery for sellar tumors., Pituitary, 19:6;552-559, 2016.

0440B003(Y.Hayashi), D.Kita, I.Fukui, Y.Sasagawa, M.Oishi, M.Okajima, O.Tachibana, M.Nakada:Pediatric symptomatic
Rathke cleft cyst compared with cystic craniopharyngioma., Child's nervous system : ChNS : official journal of theInternational Society for Pediatric Neurosurgery, 32:9;1625-1632, 2016.

0440B004

Y.Hayashi, D.Kita, M.Iwato, I.Fukui, M.Oishi, T.Tsutsui, O.Tachibana, M.Nakada:Significant improvement of
intractable headache after transsphenoidal surgery in patients with pituitary adenomas; preoperative
neuroradiological evaluation and intraoperative intrasellar pressure measurement, Pituitary, 19:2;175-182, 2016.

0440B005(Y.Sasagawa), O.Tachibana, M.Doai, Y.Hayashi, H.Tonami, H.Iizuka, M.Nakada:Carotid artery protrusion anddehiscence in patients with acromegaly, Pituitary, 19:5;482-487, 2016.

0440B006

J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato:Learning impairment byminimal cortical injury in a mouse model of Alzheimer's disease., Brain research, 1637:56-63, 2016.

Case Reports
0440D001(Y.Sasagawa), O.Tachibana, A.Nakagawa, S.Nakada, T.Nojima, D.Koya, H.Iizuka:Rapid enlargement of an
intracranial germ cell tumor after gonadotropin hormone therapy, JOURNAL OF CLINICAL NEUROSCIENCE,
31:185-188, 2016.

Presentations at Conference
International Conference (Presentations)
0440I001

M.Doai, H.Tonami, O.Tachibana:Utility of Histogram Analysis of Apparent Diffusion Coeffisient Value forDistinguishing Pituitary Atypical Adenomas from Typical Adenomas, International Society for Magnetic Resonancein Medicine 24th Annual Meeting and Exhibition 2016, Singapore, 2016.

0440I002

T.Tsukada, H.Shimada, W.He, H.Sakata-Haga, H.Iizuka, T.Hatta:Critical role of SOCS3 in the suppression of thematernal–fetal leukemia inhibitory factor signal relay pathway for fetal brain development, 5th Conference on
Prenatal Programming and Toxicity, Kokura, 2016.

0440I003

O.Tachibana, Y.Sasagawa, A.Nakagawa, D.Koya, Y.Hayashi, M.Nakada, H.Iizuka:Expression of proinflammatory
cytokines and receptors in symptomatic Rathke cleft cysts - a possible mediator of secondary hypophysitis with
Rathke cleft cyst -, Euro-pit and 14th IPPC meeting in Annecy, Lyon, 2016.

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0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Associate Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA Akiko

Plastic and Reconstructive Surgery

Senior Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

YAGISHITA Mikio

Plastic and Reconstructive Surgery

Assistant Professor

SAKAGAMI Akihiko

Plastic and Reconstructive Surgery

Assistant Professor

YONEZAWA Minami

Plastic and Reconstructive Surgery

Keywords of Researchfibroblast, FGF receptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocyte, wound healing, craniofacial surgery,zygoma, cleft lip, cleft palate, microtia, tissue expansion, crainofacial cleft, front-orbital advancement, microsurgery, freeflap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in congenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

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Publications
Originals
0450B001

T.Miyanaga, K.Shimada, M.Kishibe, H.Daizo, A.Komuro:Perifascial areolar tissue grafting for treating syndactyly
with bone fusion in patients with Apert syndrome., Journal of plastic surgery and hand surgery, 50:1;40-43, 2016.

Presentations at Conference
International Conference (Presentations)
0450I001

A.Sakagami, M.Yamashita, H.Daizo, A.Yamashita, M.Kishibe, K.Shimada, S.Kawakami:Correction of lateposttraumatic enophthalmos using an antral balloon, The 13th Japan-Korea Congress of Plastic and Reconstructive
Surgery, Kanazawa, 2016.

0450I002

T.Miyanaga, S.Kawakami:The double volar flap for repair of syndactyly without skin graft, The 13th Japan-Korea
Congress of Plastic and Reconstructive Surgery, Kanazawa, 2016.

0450I003

A.Yamashita, M.Yamashita, K.Shimada, S.Kawakami:Three-dimensional computed tomography venography as a
guide for cranioplasty in parietal cephalocele (poster), The 13th Japan-Korea Congress of Plastic andReconstructive Surgery, Kanazawa, 2016.

0450I004

Y.Himi, K.Makimoto, S.Kawakami:Experience of using intraoperative ultrasonic echo for treatment of independent
zygomatic arch fracture, The 13th Japan-Korea Congress of Plastic and Reconstructive Surgery, Kanazawa, 2016.

0450I005

K.Shimada, S.Kawakami:“A Tin Hand” on behalf of“ A Lead Hand”-A Simple Holding Device For Hand Surgery-,The 13th Japan-Korea Congress of Plastic and Reconstructive Surgery, Kanazawa, 2016.

0450I006(K.Makimoto), Y.Himi, Y.Morimoto, K.Shimada:Two cases of Intractable Cutaneous Ulcer with Postoperative
Lymphorrhea by using Negative Pressure Wound Therapy, The 13th Japan-Korea Congress of Plastic andReconstructive Surgery, Kanazawa, 2016.

0450I007

Ａ.Komuro, A.Okamura, H.Taguchi, A.Takeuchi, K.Michisita:Ocular torticollis secondary to a pediatric orbital
floor fracture, The 13th Japan-Korea Congress of Plastic and Reconstructive Surgery, Kanazawa, 2016.

0450I008

A.Yamashita, M.Yamashita, S.Kawakami:Indications for emergency surgery in pediatric orbital floor fractures,
Asian Pacific Craniofacial Association 2016, Nara, 2016.

0450I009

T.Kuroda, M.Yamashita, S.Kawakami:Bilateral sagittal split osteotomy without skeletal fixation, Asian Pacific
Craniofacial association 2016, Nara, 2016.

0450I010

M.Yamashita:Fronto-orbital advancement: To distract or not to distract?, Asian Pacific Craniofacial Association
2016, Nara, 2016.

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0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Senior Assistant Professor

YOSHIZAKI Hisayoshi Pediatric surgery

Senior Assistant Professor

YASUI Yoshitomo

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Assistant Professor

TAKAHASHI
Sadayoshi

Pediatric surgery

Assistant Professor

SATOMI Miwa

Pediatric surgery

Assistant Professor

SHIRONOMAE
Tsubasa

Pediatric surgery

Faculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma,

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

H.Yoshizaki, H.Ogiso, T.Okazaki, E.Kiyokawa:Comparative lipid analysis in the normal and cancerous organoids of
MDCK cells., Journal of Biochemistry, 159:6;573-584, 2016.

Case Reports
0460D001

Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hairhypoplasia associated with isolated hypoganglionosis: A case report., Congenital anomalies, 52:32-34, 2016.

0460D002

R.Fujisawa, T.Nakamura, K.Ishimaru, S.Toki, G.Ko, C.Akita, T.Nakamura, H.Sato, T.Kuwahara, M.Kohno,
Y.Saikawa: Painless bloody stool due to a Meckel diverticulum in infant : a case report, Japanese Journal of
Pediatrics, 69:10;1651-1655, 2016.

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Others
0460F001

M.Kohno, T.Taguchi, T.Iwanaka, T.Okamatsu:Accessory Ear and Cervical Ear, Operative General Surgery in
Neonates and Infants, 89-91, 2016.

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0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis, electromagnetic ocular injury,
ultraviolet

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Associate Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

cataract

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Assistant Professor

OSADA Hiromi

cataract, ophthalmology, macular degeneration

Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology, oxidative stress and eye disease

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology, oxidative stress and eye disease

Assistant Professor

TAKAHASHI Yorikocataract

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics, epidemiology, ultraviolet

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

SHIBATA Teppei

cataract, oxidative stress and eye disease

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland, China and Tanzania). These studies have included prevalence,incidence and risk factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we
have worked on image analysis of the crystalline lens, drew up a new classification system for cataract, and done researchon visual performance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using
animal models and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative
drug for PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

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Publications
Originals
0470B001

M.Fukuda, H.Sasaki:In vivo meaurement of human corneal impedance value, Cornea, 35:1305-1307, 2016.

0470B002

M.Fukuda, N.Takeda, S.Shibata, N.Shibata, T.Shibata, K.Sugiyama, H.Sasaki:In vitro and in vivo corneal effects oflatanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide, European Journal of Pharmacology,
787:43-46, 2016.

0470B003

T.Shibata, Y.Takahashi, A.Okamoto, H.Sasaki, K.Kitagawa:An adult case of fulminant mumps keratitis withpositive viral RNA in aqueous humor detected by RT-PCR, Cornea, 35:569-571, 2016.

0470B004

S.Shibata, N.Shibata, T.Shibata, H.Sasaki, DP.Singh, E.Kubo:The role of Prdx6 in the protection of cell of thecrystalline lens from oxidative stress induced by UV exposure, Japanese Journal of Ophthalmology, 60:408-418,
2016.

0470B005

T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:Propolis, a constituent of honey, inhibits
the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, Journal of
Ophthalmology, 2016;1917093, 2016.

0470B006(SP.Singh), B.Chhunchha, N.Fatma, E.Kubo, SP.Singh, DP.Singh:Delivery of a protein transduction domainmediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells, American
Journal of Physiology-Cell Physiology, 310:C-1-C-16, 2016.

Presentations at Conference
International Conference (Symposium)
0470H001

E.Kubo:Tropomyosin and its relationship with posterior capsular opacity, Crystalline Lens 2016 at Wakayama;
Basic and Clinical Aspects, Wakayama, 2016.

International Conference (Presentations)
0470I001(Y.Suzuki), M.Kojima, J.Chakarothai, K.Sasaki, M.Taki, H.Sasaki:Investigation on corneal epithelium damage
thresholds by CEM43℃ criterion due to millimeter-wave electromagnetic field exposure, The Association for
Research in Vision and Ophthalmology 2016, Seattle, 2016.

0470I002

S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Age-related cataract and expression level ofdecorin in human eye: association with opacity severity, The Association for Research in Vision and Ophthalmology
2016, Seattle, 2016.

0470I003

H.Sasaki, M.Kita, H.Miyashita, N.Tanimura, H.Osada, T.Shibata, Y.Takahashi, S.Shibata, E.Kubo:Influence of age
on visual function of eyes with cataract, The Association for Research in Vision and Ophthalmology 2016, Seattle,
2016.

0470I004

E.Kubo, T.Shibata, S.Shibata, H.Sasaki, E.Kiyokawa, M.Ikawa, DP.Singh:Knock-down of Tropomyosin 2 created by
CRISPR-CAS9 in mouse induces age-related-cataract, The Association for Research in Vision and Ophthalmology
2016, Seattle, 2016.

0470I005

N.Tanimura, E.Shibuya, M.Kita, A.Okamoto, N.Mita, N.Hatsusaka, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Visualfunction of eyes with waterclefts, The Association for Research in Vision and Ophthalmology 2016, Seattle, 2016.

0470I006

H.Miyashita, H.Osada, E.Shibuya, N.Tanimura, T.Shibata, S.Shibata, K.Sasaki, E.Kubo, H.Sasaki:Evaluation ofwaterclefts by anterior segment OCT, The Association for Research in Vision and Ophthalmology 2016, Seattle,
2016.

0470I007

H.Sasaki, E.Shibuya, M.Sasaki, M.Kita, H.Osada, N.Shibata, E.Kubo:Posterior capsular wrinkles in eyes with 1piece intraocular lens, ESCRS Annual Congress 2016, Copenhagen, 2016.

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0475

Department of Otorhinolaryngology

Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Auditory physiology, Equilibrium neuroscience

Associate Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology, Otology

Senior Assistant Professor

TERAGUCHI Kanako Rhinology, generel otology

Senior Assistant Professor

YAO Toru

Otology, Rhinology

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

NODA Takuya

General otorhinolaryngology

Assistant Professor

YAMADA Kentaro

General otorhinolaryngology

Assistant Professor

INAGAKI Shingo

General otorhinolaryngology

Assistant Professor

HARITA Masayuki

General otorhinolaryngology

Faculty

Keywords of Researcholfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep
apnea & snoar surgery

Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Teraguchi, Yamamoto, Yamada,Noda, Harita)
New educational system for endoscopic sinus surgery(Miwa , Shiga, Teraguchi)
Auditory central functional imaging with MEG(Suzuka, Teraguchi)
Clinical research for snoar and sleep apnea(Miwa, Sakai)

Presentations at Conference
International Conference (Key Note Lecture)
0475G001

T.Miwa:Recent advance of diagnosis and treatment of olfactory disorders, The 101st annual meeting of Taiwan
Otolaryngological Society, Taoyuan, 2016.

International Conference (Symposium)
0475H001

H.Shiga, T.Miwa:Clinical value of olfactory molecular imaging, 17th International symposium on olfaction and taste,
Yokohama, 2016.

0475H002

T.Miwa:TOPICAL THERAPIES, 26th Congress of the european rhinologic society, Stockholm, 2016.

0475H003

T.Miwa:Managing olfactory loss, 26th Congress of the european rhinologic society, Stockholm, 2016.

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International Conference (Presentations)
0475I001

Y.Nakamura, T.Miyazawa, T.Miwa:A case of inflammatory myofibroblastic tumor occurred from the larynx, The
16th Japan-Korea joint meeting of otorhinolaryngology-head and neck surgery, Tokyo, 2016.

0475I002

T.Hiraba, Y.Nakamura, T.Noda, K.Yamada, J.Yamamoto, K.Teraguchi, H.Shiga, T.Miwa:The relationship between
olfactory dysfunction and the number of eosinophils in nasal polyp tissues in surgical cases, 17th International
symposium on olfaction and taste, Yokohama, 2016.

0475I003

J.Ymamoto, H.Shiga, T.Hiraba, Y.Nakamura, M.Harita, T.Noda, K.Yamada, T.Miwa:Bilateral dysgeusia after headtrauma, 17th International symposium on olfaction and taste, Yokohama, 2016.

0475I004

K.Yamada, H.Shiga, H.Ninomiya, J.Ymamoto, T.Noda, M.Harita, Y.Nakamura, T.Hiraba, T.Miwa:An investigation
into the differences in damage of the olfactory epithelium between female and male mice after administration ofmethimazole, 17th International symposium on olfaction and taste, Yokohama, 2016.

0475I005

T.Noda, H.Shiga, H.Ninomiya, Y.Nakamura, T.Hiraba, M.Harita, K.Yamada, J.Yamamoto, T.Miwa:Effect of Kampo
medicine Tokishakuyakusan on olfactory epithelium in olfactory impaired mice, 17th International symposium on
olfaction and taste, Yokohama, 2016.

0475I006

Y.Nakamura, H.Shiga, H.Ninomiya, T.Noda, K.Yamada, M.Harita, T.Hiraba, J.Yamamoto, T.Miwa:Direct transportof insulin to the olfactory bulb of mice by nasal administration, 17th International symposium on olfaction andtaste, Yokohama, 2016.

0475I007

M.Harita, H.Shiga, T.Hiraba, Y.Nakamura, T.Noda, K.Yamada, H.Ninomiya, T.Miwa:Behavioral assessment ofmouse olfaction using a new experimental device, 17th International symposium on olfaction and taste, Yokohama,
2016.

0475I008

M.Kumai, T.Miwa:The relationship between olfactory dysfunction and the number of eosinophils in nasal polyps,
26th Congress of the european rhinologic society, Stockholm, 2016.

0475I009

M.Harita, H.Shiga, T.Hiraba, Y.Nakamura, T.Noda, K.Yamada, H.Ninomiya, T.Miwa:Observation of odor behavior
by the new simple device in mice, 26th Congress of the european rhinologic society, Stockholm, 2016.

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0485

Department of Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

KISHIMOTO Kazuhiro Head and neck surgery

Keywords of Researchhead and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle
aspiration cytology, chemoradiotherapy

Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode)
New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government
cooperation (Tsuji, Shimode)
Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji,
Shimode)Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)

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0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Senior Assistant Professor

TAKEDA Kiminobu

Medical mycology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Associate Professor

WATANABE Seiji

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, Langerhans cell,

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Publications
Originals
0490B001

K.Takeda, H.Mochizuki, K.Izumi, Y.Sakata, T.Ushigami, A.Nishibu, K.Anzawa,T.Mochizuki:Polyclonality of
Trichophyton rubrum isolates in a dermatophytosis patient with multiple lesions, Medical Mycology Journal, 57:1720, 2016.

0490B002

T.Nakamura, A.Nishibu, N.Yoshida, M.Yasoshima, K.Anzawa, Y.Watanabe, Y.Nagai, K.Takatsu, K.Ogawa,T.Mochizuki:Glycyrrhetinic acid inhibits contact hypersensitivity induced by trichophytin via dectin-1.,
Experimental Dermatology, 25:299-304, 2016.

0490B003

M.Higashino, T.Yabe, S.Matsuda, K.Takeda, K.Anzawa, T.Mochizuki, K.Makimura, S.Saijyo, Y.Iwakura, H.Toga,
A.Nakamura:A critical role of Dectin-1 in hypersensitivity pneumonitis., Inflammation Research, 65:3;235-244,
2016.

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Reviews
0490C001

T.Mochizuki:Cutaneous mycoses: management and education in universities and their clinics in Japan, Medical
Mycology Journal, 57:2;J89-J94, 2016.

0490C002

T.Mochizuki, K.Takeda, K.Anzawa:Molecular Markers Useful for Intraspecies Subtyping and Strain Differentiationof Dermatophytes., Mycopathologia, 182:1;57-65, 2016.

Presentations at Conference
International Conference (Key Note Lecture)
0490G001

T.Mochizuki:Molecular epidemiology of dermatophytoses, Taiwanese Dermatological Association Spring Meeting
2016, Takao, 2016.

0490G002

T.Mochizuki:Nosocomial dermatophytosis, Taiwanese Dermatological Association Spring Meeting 2016, Takao,
2016.

International Conference (Symposium)
0490H001

T.Mochizuki:Superficial Mycoses: Introduction & Clinical Symptoms. Precongress APSMM-MMTN workshop, The
6th Asia Pacific Society for Medical Mycology Congress, Bali, 2016.

0490H002

T.Mochizuki:Recent trend of diagnosis and treatment of onychomycosis, The 4th Eastern Asia DeramtologiyCongress, Tokyo, 2016.

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0500

Department of Urology

Faculty
Title

Name

Field of Specialization

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

NAKAI Dan

general urology

Assistant Professor

INOUE Shinya

general urology

Assistant Professor

NAKAZAWA Yusuke

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence,

Outline of Researchclinical research on renal transplantation, mechanism of urolithiasis

Publications
Originals
0500B001

I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, T.Ishii, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Ota, M.Matoba,
K.Miyazawa:The effect of radiation therapy for bone metastasis in urinary organ cancer, Japanese Journal of
Urology, 107:1;7-12, 2016.

Case Reports
0500D001

Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, M.Matoba,
K.Sato,and K.Miyazawa:A case of renal cell carcinoma metastasized to gluteal muscle after partial nephrectomy,
Japanese Journal of Urological Surgery, 29:2;177-180, 2016.

0500D002

I.Chikazawa, N.Morita, T.Tanaka, K.Sato, K.Miyazawa:Peritoneal carcinomatosis due to direct liver invasion
arising from renal cell carcinoma : a case report, Japanese Journal of Clinical Urology, 70:7;543-546, 2016.

0500D003

K.Nagata, Y.Tanaka, M.Matsumoto, C.Tanaka, K.Nitta, K.Miyazawa, Y.Iinuma:A case of 2,8-dihydroxyadenine
crystal urine that did not show urine calculus, Japanese Journal of Medical Technology, 65:6;695-699, 2016.

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Presentations at Conference
International Conference (Presentations)
0500I001

D.Nakai, S.Inoue, Y.Nakazawa, N.Morita, K.Miyazawa, Y.Ishigaki:Febuxostat reduces calcium oxalate monohydrate
crystal-induced upregulation of MCP-1 in MDCK cells, 13th International Symposium on Urolithiasis, Makuhari,
2016.

0500I002

N.Morita, S.Inoue, Y.Nakazawa, D.Nakai, K.Miyazawa:Microplate method for measurement of urinary
supersaturation to indicate stone reccurence of calcium oxalate, 13th International Symposium on Urolithiasis,
Makuhari, 2016.

0500I003

N.Morita, S.Inoue, Y.Nakazawa, D.Nakai, K.Miyazawa:Impact of preoperative stenting to flexible ureterorenoscopeon outcomes and patient quality of life, 13th International Symposium on Urolithiasis, Makuhari, 2016.

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0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

Professor

SASAGAWA Toshiyuki

Gynecologic Pathology, Tumor Virology, Sexually Transmitted
Infection Research, Immunology

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

OSAKA Yasuhiro

perinatal medicine

Assistant Professor

SAKAMOTO Jinichi

perinatal medicine, reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

Publications
Originals
0510B001

S.Fujita:Evaluation of Efficacy of Drug Therapy for HPV Infection-Related Diseases of Cervix and Vagina, andAnalysis of Factors Influencing the Therapeutic Effect, Journal of Kanazawa Medical University, 41:43-50, 2016.

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0510B002

S.Fujita, T.Sasagawa:Ablation therapy for cervical and vaginal intraepithelial tumors and Analysis of factors
influencing the therapeutic effect, Japanese journal of sexually transmitted infections, 27:1;61-67, 2016.

0510B003

T.Sasagawa, T.Maehama, K.Ideta, T.Irie, F.Itoh, J-HERS Study Group:Population-based study for humanpapillomavirus (HPV) infection in young women in Japan: A multicenter study by the Japanese humanpapillomavirus disease education research survey group (J-HERS), Journal of medical virology, 88:324-335, 2016.

0510B004

T.Shibata, S.Makinoda, T.Waseda, H.Tomizawa, R.Fujii, T.Utsunomiya:Granulocyte colony-stimulating factor as apotential inducer of ovulation in infertile women with luteinized unruptured follicle syndrome, Translational
Research, 171:63-70, 2016.

0510B005

T.Shibata, J.Sakamoto, Y.Osaka, N.Neyatani, S.Fujita, Y.Oka, H.Takagi, H.Mori, H.Fujita, Y.Tanaka,
T.Sasagawa:Myeloperoxidase in blood neutrophils during normal and abnormal menstrual cycles in women of
reproductive age, International Journal of Laboratory Hematology, 39:169-174, 2016.

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0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Senior Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, Shock

Senior Assistant Professor

HONMA Keiko

Clinical anesthesia, Palliative medicine

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

TAKANO Mami

Clinical anesthesia

Assistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

TAKAHARA Asami

Clinical anesthesia

Assistant Professor

KANEKO Yuriko

Clinical anesthesia

Assistant Professor

MORIKAWA Takanori Clinical anesthesia

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

UEDA Keiko

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Others
0520F001

M.Ogawa, K.Honnma, H.Kida, Y.Yamaoka, Y.Tanaka, H.Araki, M.Takano, T.Morikawa, K.Ueda, S.Matsuba,
S.Miyajima, H.Tsuchida:Perioperative risk stratification model, 40:12;1707-1712, 2016.

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0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAGECHIKA Kenjirehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL,

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Presentations at Conference
International Conference (Presentations)
0540I001

Y.Takagi, A.Nakanami, K.Kagechika, T.Yahata:Intrathecal Baclofen （ITB） therapy to severe spasticity, 10th
World Congress of the International Society of Physical and Rehabilitation Medicine (ISPRM) World Congress,
Kuala Lumpur, 2016.

0540I002

K.Kagechika, S.Ohkubo, T.Ohshima, M.Nakata, M.Tsubokawa, F.Takeuchi, W.Ohsu, Y.Takagi,
A.Nakanami:Utility of mirror treatment method with digital image display device in stroke patients with upper arm
dysfunction, 10th World Congress of the International Society of Physical and Rehabilitation Medicine (ISPRM)World Congress, Kuala Lumpur, 2016.

0540I003

K.Kagechika, M.Nakata, M.Tsubokawa, F.Takeuchi, W.Ohsu, Y.Takagi, A.Nakanami:An estimation method ofvolume and trabecula architecture of cancellos bone in hemiplegic patients, 10th World Congress of theInternational Society of Physical and Rehabilitation Medicine (ISPRM) World Congress, Kuala Lumpur, 2016.

0540I004

K.Kagechika, M.Nakata, M.Tsubokawa, F.Takeuchi, W.Ohsu, Y.Takagi, A.Nakanami:A stroke patient withpersistent disturbance of consciousness who recovered from cervical dystonia and could communicate by using
botulinum toxin type A treatment, 10th World Congress of the International Society of Physical and Rehabilitation
Medicine (ISPRM) World Congress, Kuala Lumpur, 2016.

0540I005

K.Kagechika, M.Nakata, M.Tsubokawa, F.Takeuchi, W.Ohsu, Y.Takagi, A.Nakanami:Relationship between the skin
impedance of stroke patients and pain measurement, 10th World Congress of the International Society of Physicaland Rehabilitation Medicine (ISPRM) World Congress, Kuala Lumpur, 2016.

-80-

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

WATANABE Atsushi

Emergency

Assistant Professor

USHIMOTO Tomoyuki Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care,

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

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0570

Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

TAKAMURA Akiteru

Community-based Medical Education，Community Medicine，General
Practice，General Paediatrics

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

USUDA Daisuke

General Medicine

Senior Assistant Professor(Additional Post)
Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy,

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

A.Takamura, S.Ito, K.Maruyama, Y.Ryo, M.Saito, S.Fujimura, Y.Ishiura, A.Hori:Quality status of BLS education
and AED setting in schools in Ishikawa, Japan., Pediatrics international : official journal of the Japan PediatricSociety, 59:3;352-356, 2016.

0570B002

D.Usuda, R.Sangen, Y.Hashimoto, E.Muranaka, Y.Iinuma, T.Kanda:Validation of a B-type natriuretic peptide as aprognostic marker in pneumonia patients: a prospective cohort study, BMJ open, 6:2;e010440, 2016.

0570B003

M.Taga, D.Usuda, Y.Noda, Y.Iinuma, Y.Nishita, Y.Yamamoto, O.Niwa:Usability by the colorimetric method formeasurement of chlorine concentration in hypochlorite solutions and factors for change of the concentration,
Japanese Journal of Environmental Infections, 31:5;314-317, 2016.

Reviews
0570C001

A.Takamura:The new era of postgraduate certified general practice training in Japan., Education for primary care :an official publication of the Association of Course Organisers, National Association of GP Tutors, World
Organisation of Family Doctors, 27:5;409-412, 2016.

Case Reports
0570D001 D.Usuda, R.Sangen, Y.Iwata, T.Kanda:Interstitial Pneumonia in a 94-Year-Old Woman with MPO-ANCA Positive
Vasculitis, Case Reports in Clinical Medicine, 5:61-65, 2016.
0570D002

D.Usuda, M.Arahata, R.Temaru, Y.Iinuma, T.Kanda, S.Hayashi:Autopsy-proven intravascular lymphoma
presenting as rapidly recurrent strokes, Case reports in oncology, 9:1;148-153, 2016.

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Presentations at Conference
International Conference (Presentations)
0570I001

K.Kawamura, Y.Iinuma, D.Usuda, M.Matsumoto, Y.Tanaka, M.Kawano, S.Tateyama, Y.Itose:Evaluation of urine
flow cytometer Sysmex UF-5000:the comparison with routine methods for identifying bacteria, The 32nd World
Congress of Biomedical Laboratory Science, Kobe, 2016.

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0575

Department of Gastroenterological Endoscopy

Faculty
Title

Name

Professor

ITO Tohru

Associate Professor
Associate Professor
Senior Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Field of Specialization

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
URASHIMA Sachio

Diagnosis for esophagus, Hepato-biliary-pancreatic treatment

Diagnosis for esophagus, gastro-intestine, colon, disease.
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KOBAYASHI Rika
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
KAWAURA Ken

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Originals
0575B001

K.Hamada, T.Itoh, K.Kawaura, S.Azukisawa, R.Kobayashi, H.Okamura, H.Kitakata, S.Urashima, T.Nojima,
M.Fujino:Findings of the margin around lesions by magnifying endoscopy with narrow-band imaging in early gastriccarcinoma and intestinal metaplasia., Journal of digestive diseases, 17:6;377-382, 2016.

-84-

Presentations at Conference
International Conference (Presentations)
0575I001

H.Kitakata, T.Itoh, S.Kinami, S.Azukisawa, R.Kobayashi, K.Hamada, K.Kawaura, T.Kosaka:A clinical study ofendoscopic full-thick-ness resection by serosa sealing method for submucosal invasive gastric cancer without
sentinel node metastasis., UEGW2016, Venue, 2016.

0575I002

K.Hamada,T.Itoh:Usefulness of the margin around lesion findings by magnifying endoscopy with nar-row-band
imaging in early gastric carcinoma., UEGW2016, Venue, 2016.

0575I003

K.Kawaura, K.Hamada, H.Kitakata, H.Okamura, S.Urashima, T.Itoh:Consideration of the percutaneous endoscopic
gastrostomy., APDW2016, Kobe, 2016.

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0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

MATSUMOTO Gouichi Bone Regeneration, Biomaterials, Oral Cancer

Associate Professor

ISHIBASHI Hiroaki

Oral tumor, Oral Pathology

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Senior Assistant Professor

KATO Takao

Oral cavity, Kampo medicines, Dental pharmacology

Assistant Professor

KATO Koichiro

Oral tumor

Assistant Professor

HASUMOTO Miho

Orthodontics

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery, kampo medicines, dental pharmacology

Outline of Research
1. Basic and clinical research for disorders of temporomandibular joints.
2. Molecular biological research for growth and metastasis of tumors in oral region.
3. Pathophysiological research for abnormal development of oral and maxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central nervous systems.
6. Studies on the pharmacological mechanism of Kampo medicine.

Publications
Originals
0580B001

T.Kato, N.Segami, H.Sakagami:Anti-inflammatory Activity of Hangeshashinto in IL-1β-stimulated Gingival andPeriodontal Ligament Fibroblasts, In vivo (Athens, Greece), 30:3;257-264, 2016.

0580B002

H.Ishibashi:A Novel Gene Therapy to Treat Lesions of the Teeth, Oral Cavity, and Maxillofacial Region, Journal ofJapan Association of Dental Traumatology, 12:1;19-25, 2016.

Reviews
0580C001

N.Segami:<TMJ luxation：Measures in aging society> Strategy and proposal flow-chart in surgery for
temporomandibular joint dislocation, Journal of the Japanese Society for the Temporomandibular Joint, 28:1;14-21,
2016.

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School of Nursing

8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Nursing history, Nursing skills

Professor

TAKIUTI Takako

Nursing history, Nursing skill

Associate Professor

MATSUI Yuko

Nursing skill

Senior Assistant Professor

SUGIMORI Chiyoko

Nursing skill

Assistant Professor

OKAYAMA Miki

Patient education for diabetes

Assistant Professor

MIYANAGA Aiko

Wound Care Nursing, Nursing skills

Keywords of Researchfundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care

Outline of Research
1. Verification of nursing skills
2. Study of nursing education

Publications
Originals
8010B001

C.Sugimori, M.Inagaki:The experiences of elderly patients with early cancer waiting for gastrointestinal endoscopic
surgery, Journak of Society of Nursing Practice, 28:2;16-26, 2016.

8010B002(H.Tanabe), T.Takahasi, R.Murayama, K.Yabunaka, M.Oe, Y.Matsui, R.Arai, M.Uchida, C.Komiyama,
H.Sanada:Using ultrasonography for vessel diameter assessment to prevent infiltration, Journal of Infusion Nursin,
39:2;105-111, 2016.

8010B003(T.Yokono), H.Sanada, J.Sugama, C.Konya, M.Okuwa, Y.Matsui, J.Matsuo, S.Kinoshita, Y.Ichikawa, T.Kaitani,
A.Sato, Y.Fujimoto: Evaluation of the utility of a collaborative skills scale developed for self-assessment by wound,ostomy, and continece nurses for pressure ulcer management according to nurses' years of experience, Journal ofJapanese Society of Wound, Ostomy and Continence Management, 20:1;32-42, 2016.

8010B004

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Catheter blockage factors in patients cared for in
their own home requiring long-term urinary catheterisation, International Journal of Urological Nursing, 1-8, 2016.

Case Reports
8010D001(M.Oya), T.Takahashi, H.Tanabe, M.Oe, R.Murayama, K.Yabunaka, Y.Matsui, H.Sanada:Low-temperature
infiltration identified using infrared thermography in patients with subcutaneous edema evealed
ultrasonographically: A case report, Drug Discoveries & Therapeutics, 10:2;117-122, 2016.

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Others
8010F001(T.Kadono), K.Furuta, Y.Nagai, H.Kanoh, Y.Sekine, Y.Noda, F.Mizokami, H.Kataoka, H.Nakagawa, K.Tanaka,
T.Daian, Y.Kurashige, G.Nakagami, N.Makabe, R.Sekine, M.Takasaki, K.Yoshiro, T.Endo, M.Hidaka, N.Maeshige,
K.Kubota, T.Morita, M.Okuwa, M.Miyajima, M.Noguchi, S.Kinoshita, M.Sobue, Y.Matsui, Y.Murooka,
Y.Ishida:JSPU guidelines for the prevention and management of pressure ulcers (4th Ed.), Japanease Journal ofPressure Ulcers, 18:4;455-544, 2016.

Presentations at Conference
International Conference (Presentations)
8010I001

S.Maeda, T.Takiuti, M.Moriyama, Y.Kohno, H.Nakai, M.Fukuda:Development of a protocol for the prevention andmanagement of long-term indwelling urinary catheter blockage for visiting nurses, 17th international EAUN
meeting, Munich, 2016.

8010I002

Y.Matsui, J.Sugama, M.Ishizawa, N.Kamata, S.Kawakami, S.Kinosita, H.Sanada, G.Nakagami, S.Fukagawa,M.Furue, Y.Miyachi, K.Yokoo:Location of severe medical device-related pressure ulcers by anti-embolism
stockings and intermittent pneumatic compression devices in Japan, 5th Congress of World Union of Wound
Healing Societies, Firenze, 2016.

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8040

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

YANAGIHARA
MachikoMatenity Nursing，Midwifery

Senior Assistant Professor

BODA Hitomi

Matenity Nursing，Midwifery

Senior Assistant Professor

IWATANI Kumiko

Matenity Nursing，Midwifery

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing, Midwifery

Keywords of Research
Practice, Pregnancy, Midwife, Maternity Nursing, perinatal, after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation, Dioxin

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care,
Dioxin.

Publications
Originals
8040B001

K.Iwatani, K.Shimada:A descriptive study of student incident characteristics during birth assistance practicaltraining: An educational perspective, Journal of the Tsuruma Health Science Society, 40:1;55-64, 2016.

Presentations at Conference
International Conference (Presentations)
8040I001

K.Iwatani, S.Yoshida, K.Kanamori, C.Yamazaki, M.Izuhara, K.Shimada:Challenges of Safety Management Guidanceas Part of Skilled Birth Attendance Training, East Asian Forum of Nursing Scholars 19th, Chiba, 2016.

8040I002

M.Nishijo, PN.Thao, PT.Tai, T.Anh, H.Boda, S.Nagasawa, Y.Nishino, H.Nishijo:Neurotoxic effects of perinatal
dioxin exposure on children in Vietnam:Two birth cohort studiies in hot spots of dioxin contamination from Agent
Orange, pptoxⅤ, Kitakyusyu, 2016.

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8050

Pediatric Nursing

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

HASHI Shinobu

Single mother, asthma, child, belief, parenting stress

Assistant Professor

TERAI Takahiro

Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment,

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention

-90-

8060

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Professor

OBATA Mitsuko

Critical care

Associate Professor

MURAKADO Naoko

Chronic nursing，Diabetes nursing

Senior Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Senior Assistant Professor

KINOSHITA Sachiko

Wound Care, Stoma care, Continence care

Assistant Professor

ASANO Kimi

Wound Care

Assistant Professor

Natsuko Yamada

Critical Care

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care, Critical Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8060B001(T.Yokono), H.Sanada, J.Sugama, C.Konya, M.Okuwa, Y.Matsui, J.Matsuo, S.Kinoshita, Y.Ichikawa, T.Kaitani,
A.Sato, Y.Fujimoto:Evaluation of the utility of a collaborative skills scale developed for self-assessment by wound,ostomy, and continece nurses for pressure ulcer management according to nurses' years of experience, Journal ofJapanese Society of Wound, Ostomy and Continence Management, 20:1;32-42, 2016.

8060B002(E.Komatsu), Y.Nakajima, K.Mukai, T.Urai, K.Asano, M.Okuwa, J.Sugama, T.Nakatani:Lymph Drainage During
Wound Healing in a Hindlimb Lymphedema Mouse Model, Lymphatic Research and Biology, 2:1-9, 2016.

8060B003(S.Waki), Y.Shimizu, K.Uchiumi, K.Asou, N.Kuroda, N.Murakado, N.Seto, H.Masaki, H.Ishii:Structural model ofself-care agency in patients with diabetes: A path analysis of the Instrument of Diabetes Self-Care Agency andbody self-awareness, Japan journal of nursing science, 13:4;478-486, 2016.

Short Communications
8060E001

C.Konya, Y.Mizokami, R.Kamide, N.Ohura, K.Tokunaga, H.Sanada, G.Nakagami, M.Abe, M.Okuwa, H.Noguchi,
S.Iizaka, M.Kase, H.Koyanagi, M.Sobue, M.Takahashi, M.Tanabe, A.Tichiori, A.Naito, N.Nakamura, N.Mamiya,
T.Miyanaga, K.Yamada:Epidemiology of skin tears caused by the medical adhesive tape, Journal of JapaneseSociety of Wound, Ostomy and Continence Management, 20:1;43-48, 2016.

Others8060F001(T.Kadono), K.Furuta, Y.Nagai, H.Kanoh, Y.Sekine, Y.Noda, F.Mizokami, H.Kataoka, H.Nakagawa, K.Tanaka,
T.Daian, Y.Kurashige, G.Nakagami, N.Makabe, R.Sekine, M.Takasaki, K.Yoshiro, T.Endo, M.Hidaka, N.Maeshige,
K.Kubota, T.Morita, M.Okuwa, M.Miyajima, M.Noguchi, S.Kinoshita, M.Sobue, Y.Matsui, Y.Murooka,
Y.Ishida:JSPU guidelines for the prevention and management of pressure ulcers (4th Ed.), Japanease Journal ofPressure Ulcers, 18:4;455-544, 2016.

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Presentations at Conference
International Conference (Presentations)
8060I001

C.Konya, Y.Mizokami, R.Kamide, K.Tokunaga, H.Sanada, G.Nakagami:Epidemiology of Skin Tears in Japan: anationwide survey, 5th congress of the World Union of Wound Healing Societies, Firenze, 2016.

8060I002

Y.Matsui, J.Sugama, M.Ishizawa, N.Kamata, S.Kawakami, S.Kinosita, H.Sanada, G.Nakagami, S.Fukagawa,M.Furue, Y.Miyachi, K.Yokoo:Location of severe medical device-related pressure ulcers by anti-embolism
stockings and intermittent pneumatic compression devices in Japan, 5th Congress of World Union of Wound
Healing Societies, Firenze, 2016.

8060I003(K.Mukai), T.Urai, K.Asano, Y.Nakajima, T.Nakatani:Evaluation of the effect of estradiol benzoate on cutanoues
wound healing in ovariectomized female mice. Focus on the imflammatory response., 5th congress of the World
Union of Wound Healing Societies, Firenze, 2016.

8060I004(T.Urai), K.Mukai, K.Asano, Y.Nakajima, J.Sugama, T.Nakatani:Effect of obesity on cutaneous wound healing
without tension in obese mice, 5th congress of the World Union of Wound Healing Societies, Firenze, 2016.

8060I005(Y.Nakajima), K.Mukai, T.Urai, K.Asano, M.Ohta, I.Kato, A.Kawaguchi, Y.Kinoshita, Y.Kumagai,
A.Sakashita,T.Sawazaki, A.Yamazaki, T.Nakatani:Effects of honeydew honey on wound healing, 5th congress of theWorld Union of Wound Healing Societies, Firenze, 2016.

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8070

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Professor

HIRAMATSU Tomoko community/elderly nursing science

Associate Professor

KOIZUMI Yumi

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8080B001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men., Journal of diabetes investigation, 7:3;343-351,
2016.

-93-

8080

Community Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Senior Assistant Professor

IKEUCHI Satomi

public health nursing

Assistant Professor

Tonoyama Noriko

public health nursing

School hygiene

Industrial health

Keywords of Research
Public health nursing-care activity, Public health nursing education, Health promotion, activity of cmmunity organization,
Non-smoking education, School hygiene, Industrial health,Outline of Research
The Public Health nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, part of a drug abuse prevention
program for junior high school student and health maintenance.

-94-

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

HASEGAWA Masami

depression, suicide prevention, therapeutic nursing, narrative
approach

Associate Professor

FUKASAWA Yuko

Mental health, Psychiatric Nursing

Senior Assistant Professor

TANAKA Koji

Senior Assistant Professor

NAGAYAMA Yutaka

life-world led care, patient-nurse interrelationship, empathy,
psychiatric and mental health nursing
Reducing the use of coercive measures, Strength-based nursing forpsychiatric patients

Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship,
empathy, psychiatric and mental health nursing, reducing the use of coercive measures, physical restraint, seclusion,
Strengths model, Emotion Modulation Therapy

Outline of Research
The purpose of our study is to clarify the suicide prevention effect for the depression people by Narrative approach andEmotion Modulation Therapy(EMT). We are trｙing the effect of these methods as new therapeutic nursing for depression
people between our nursing clinic in Japan and Griffth University clinic in Australia.

Presentations at Conference
International Conference (Key Note Lecture)
8085G001

M.Hasegawa:Depression and nursing of elderly persons, The International Gerontological Nursing Conference
2016, Wohan, 2016.

International Conference (Presentations)
8085I001

K.Tanaka, M.Hasegawa:A case of Charles Bonnet syndrome induced by visual impairment in an elderly adult, 19th
East Asian Forum of Nursing Scholars, Chiba, 2016.

8085I002

M.Hasegawa, K.Tanaka, Y.Nagatama:The effect of Support Group for depression people by nurses, International
Conference on Spirituality and psychology 2016, Thailand, 2016.

8085I003

M.Hasegawa:The effect of a nurse-assisted depression support group, 16th International forum on Mood andAnxiety Disorders, Roma, 2016.

-95-

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
supportAssistant Professor

NAKAI Hisao

Home healthcare,Disaster Nursing,Care Management

Assistant Professor

FUKUDA Moriyoshi

Nursing care of pressure uler，Home care

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program, Psychiatric Disorder, Community besed Workshop, Recoverry"consept

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced Recoverry"consept prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B001

H.Nakai, K.Tsukasaki, K.Kyota, T.Itatani, R.Nihonyanagi, Y.Shinmei, S.Yasuoka:Factors Related to Evacuation
Intentions of Power-Dependent Home Care Patients in Japan, Journal of Community Health Nursing, 33:4;196208, 2016.

8090B002

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Catheter blockage factors in patients cared for in
their own home requiring long-term urinary catheterisation, International Journal of Urological Nursing, 1-8, 2016.

Presentations at Conference
International Conference (Presentations)
8090I001

S.Maeda, T.Takiuti, M.Moriyama, Y.Kohno, H.Nakai, M.Fukuda:Development of a protocol for the prevention andmanagement of long-term indwelling urinary catheter blockage for visiting nurses, 17th international EAUN
meeting, Munich, 2016.

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8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Kojima/electromagnetic radiation, M.
Kojima/ultraviolet exposure, M. Kojima/infrared rays exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.
K. Iwai:Role of the nuclear matrix associated proteins in the regulation of gene expression of the cardiovascular cells.
Y.Morikawa:Epidemiology of work related disease, Social epidemiology

Publications
Originals
8100B001(K.Nakamura), M.Sakurai, Y.Morikawa, S.Nagasawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa:Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective
Study in Normoglycemic Japanese Men, Experimental and clinical endocrinology & diabetes : official journal,
German Society of Endocrinology [and] German Diabetes Association, 25:1;12-20, 2016.

8100B002

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men., Journal of diabetes investigation, 7:3;343-351,
2016.

8100B003

Y.Hamazaki, Y.Morikawa, S.Morimoto, H.Nakagawa:Difference in the impact of homebound status on functional
decline between independent older men and women: A 2 year follow-up study., Japan journal of nursing science,
13:2;265-272, 2016.

8100B004

T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji:Galectin-4 expression isdown-regulated in response to autophagy during differentiation of rat trophoblast cells, SCIENTIFIC REPORTS,
6:1-11, 2016.

8100B005

K.Kitaoka, S.Masuda, K.Ohnishi, J.Nakahara, S.Takezawa, Y.Morikawa, H.Nakagawa, K.Nishimura, F.Nakamura,
K.Iihara:Rate of burnout among japanese mental health nurses assessed using the revised exhaustion+1 criterion: A
comparison across occupations and countries, Hokuriku journal of public health, 42:2;69-75, 2016.

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8100B006

T.Masuoka, M.Kudo, J.Yoshida, T.Ishibashi, I.Muramatsu, N.Kato, N.Imaizumi, M.Nishio:Long-term activation ofgroup I metabotropic glutamate receptors increases functional TRPV1-expressing neurons in mouse dorsal root
ganglia, Frontiers in Cellular Neuroscience, 10:79, 2016.

Presentations at Conference
International Conference (Symposium)
8100H001

T.Masuoka, T.Ishibashi, M.Nishio:Possible contribution of glutamate receptors in ocular hyperalgesia, XXI Biennial
Meeting of the International Society for Eye Research, Tokyo, 2016.

International Conference (Presentations)
8100I001(Y.Suzuki), M.Kojima, J.Chakarothai, K.Sasaki, M.Taki, H.Sasaki:Investigation on corneal epithelium damage
thresholds by CEM43℃ criterion due to millimeter-wave electromagnetic field exposure, The Association for
Research in Vision and Ophthalmology 2016, Seattle, 2016.

8100I002

T.Masuoka, M.Kudo, T.Ishibashi, M.Nishio:TRPA1 channel modifies membrane current induced by TRPV1channels activation in dorsal root ganglion neurons, Neuroscience 2016, San Diego, 2016.

-98-Department of General Education

8610

Natural Sciences

Faculty
Title

Name

Field of Specialization

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Associate Professor

HASHIMOTO
Mitsumasa

Radiation Biology, Cell Biology

Associate Professor

IIDA Yasuo

Function algebra,Function space

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Senior Assistant Professor

OKUDA Koichi

Fixed-quantity rating system in the heart nuclear medicine

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

INOUE Tomoki

Graph theory in toplogy

Keywords of Research
Bertrand curveMannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic fieldMannheim
curve, Frenet frame, graph theory in topology, topological polyhedron, , Nuclear medicine Nuclear cardiology, Imaging,
Image processingSPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing Radiation, DNA double strand breaks (DSBs), history ofscience, history of technologyGalileo GalileiIsaac NewtonVenetian patent law, , Metastasis, Metastasis Inducing Gene,
RhoGDIβ(LyGDI/D4GDI/RhoGDI2), , ultrastructure, pharynxspongemetamorphosis, immunoelectron microscopy,
neurosynapsneurosecretory cell, lectin, galectinβ-galactoside, Xenopusdevelopment, placenta

Outline of Research
Hashimoto:Function of DNA repair enzymes especially protection mechanisms against DNA double strand breaks induced
ionizing radiation especially protection mechanisms against DNA double strand breaks induced ionizing radiation Okuda:The
aim of our research is to develop a computer algorithm for the quantitative assessment of myocardial perfusion andsympathetic nerve activity in the nuclear cardiology.
MAEDA:Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies
have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.Further investigation of thedetails of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer.
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve. Inoue:We extend the Graph Theory and define a
topologicalpolyhedron which coverd on closed surface of genus g. We give characterizations and example of the topologicalpolyhedron.
TANAKA:The research theme is the history of early modern science and technology. The topics being studied include
Galileo Galilei and Venetian Patent Law enacted in 15th century.
１）Functional analysis of Galectins a family of ・-galactosides binding proteins. a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.

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Publications
Originals
8610B001(K.Nakajima), K.Okuda, S.Matsuo, K.Kiso, S.Kinuya, Garcia Ernest V:Comparison of phase dyssynchrony analysis
using gated myocardial perfusion imaging with four software programs: Based on the Japanese Society of Nuclear
Medicine working group normal database., Journal of nuclear cardiology : official publication of the American
Society of Nuclear Cardiology, 24:1-11, 2016.

8610B002(H.Yoneyama), K.Nakajima, K.Okuda, S.Matsuo, M.Onoguchi, S.Kinuya, Edenbrandt Lars:Reducing the smallheart effect in pediatric gated myocardial perfusion single-photon emission computed tomography., Journal of
nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 1-11, 2016.

8610B003(Klene Christiane), Jungen Christiane, K.Okuda, Y.Kobayashi, Helberg Annabelle, Mester Janos, Meyer Christian,K.Nakajima:Influence of ROI definition on the heart-to-mediastinum ratio in planar (123)I-MIBG imaging., Journalof nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016.

8610B004(K.Nakajima), K.Okuda, S.Matsuo, D.Agostini:The time has come to standardize 123I-MIBG heart-to-mediastinum
ratios including planar and SPECT methods., European Journal of Nuclear Medicine and Molecular Imaging,
43:2;386-388, 2016.

8610B005

K.Okuda, K.Nakajima, S.Sugino, Y.Kirihara, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya:Development and validationof a direct-comparison method for cardiac I-123-metaiodobenzylguanidine washout rates derived from late 3-hourand 4-hour imaging, European Journal of Nuclear Medicine and Molecular Imaging, 43:2;319-325, 2016.

8610B006

T.Arikawa, S.Liao, H.Shimada, T.Inoue, H.Sakata-Haga, T.Nakamura, T.Hatta, H.Syoji:Galectin-4 expression isdown-regulated in response to autophagy during differentiation of rat trophoblast cells, SCIENTIFIC REPORTS,
6:1-11, 2016.

Reviews
8610C001(K.Nakajima), N.Matsumoto, T.Kasai, S.Matsuo, K.Kiso, K.Okuda:Normal values and standardization of parametersin nuclear cardiology: Japanese Society of Nuclear Medicine working group database., Annals of nuclear medicine,
30:3;188-199, 2016.

Presentations at Conference
International Conference (Presentations)
8610I001

K.Okuda, K.Nakajima, C.Kitamura, M.Hori, Y.Kirihara, S.Matsuo, J. Taki, M.hashimoto, S.Kinuya:Multicenter
phantom study of characteristics of gamma cameras with LEHR collimators in cardiac 123I-MIBG imaging, SNMMI2016 Annual Meeting, San Diego, 2016.

8610I002

K.Okuda, K.Nakajima, S.Matsuo, C.Kondo, M.Sarai, Y.Shimotsu, M.Onoguchi, T.Konishi,
S.Kinuya:Characteristics of normal myocardial perfusion distribution derived from the IQ-SPECT system: A
comparison between gender-combined and specific databases, SNMMI 2016 Annual Meeting, San Diego, 2016.

8610I003(J.Taki), H.Shiga, K.Okuda, T.Miwa, A.Inaki, S.Kinuya:Prognostic value of olfactory nerve scintigraphy by pernasal TI-201 administration in patients with impaired sense of smell., SNMMI 2016 Annual Meeting, San Diego,
2016.

8610I004(K.Nakajima), T.Nakata, S.Matsuo, A Jacobson, K.Okuda, S.Kinuya:Cardiac mortality risk chart in chronic heart
failure:multivariate I-123 meta-iodobenzylguanidine risk model incorporating correction of collimator differences.,
SNMMI 2016 Annual Meeting, San Diego, 2016.

8610I005(K.Nakajima), K.Okuda, S.Matsuo, K.Kiso, S.Kinuya, E.V.Garcia:Phase dyssynchrony parameters in gatedmyocardial perfusion imaging:Normal ranges and affecting factors in four software programs., SNMMI 2016 Annual
Meeting, San Diego, 2016.

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8610I006

K.Okuda, K.Nakajima, C.Kitamura, M.Hori, Y.Kirihara, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya:Characteristics
of gamma cameras with medium-energy-type collimators in cardiac 123I-MIBG imaging:A multicenter MIBG
phantom study in Japan, EANM 2016 Annual Congress, Barcelona, 2016.

8610I007(E.Poel), DO.Verschure, K.Nakajima, K.Okuda, BLF.van Eck Smit, GA.Somsen, HJ.Verberne:A European
phantom study to cross-calibrate myocardial 1231-mlBG scintigraphy, EANM 2016 Annual Congress, Barcelona,
2016.

8610I008(S.Matsuo), K.Nakajima, K.Okuda, Y.Kunita, S.Kinuya:Comparison of phase dyssynchrony analysis among different
software programs in patients with suspected or known coronary artery disease, EANM 2016 Annual Congress,
Barcelona, 2016.

8610I009(C.S chmitt), C.Jungen, K.Okuda, Y.Kobayashil, A.Helberg, J.Mester, C.Meyer, K.Nakajima:Need forstandardization of ROI definition in planar cardiac I-123- -MIBG imaging, EANM 2016 Annual Congress,
Barcelona, 2016.

8610I010(K.Nakajima), J.Komatsu, M.Yoshita, M.Samuraki, K.Okuda, S.Kinuya, M.Yamada:Differentiation of dementia with
Lewy bodies and Alzheimer disease using standardized 1-123 metaiodobenzylguanidine heart-to- -mediastinum
ratio based on Japanese multi center study, EANM 2016 Annual Congress, Barcelona, 2016.

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8620

Human Sciences

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Senior Assistant Professor

HONDA Kojiro

Ethics of technology

Senior Assistant Professor

KIKUCHI Takeshi

Philosophy, ethics, philosophy, ethics and the education, research of
the thing supporting life, health, life, philosophy of the minority

Senior Assistant Professor

IKENAKA Masami

English Education

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Assistant Professor

MURAKAMI Yusuke

adapted physical activity

Keywords of Research
exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE class, , end of the century,
culture, the middle Ages, Modern times, Europe, , articulatory phonetics, acoustic phonetics, English phonology, Japanesephonology, pronunciation, L2 researchlanguage acquisition, medical research article, novel, individualism, quest,
existentialism, Buildungsroman, humor, irony, narration, suffering, humanity cross-cultural differences, cultural variation,
NLP, Python programming language, medical Englishe-learning, , logic, metaphysics, form, content, predicate, category,
deduction, induction, matterbeing, substance, definion, Phenomenology, Philosophy of Technology, Ethics of Technology,
Engineering Ethics, Robo-ethics, Medical Ethics, Cognitive Science of Learning, History of Science, Philosophy of Science,

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe many prominent intellects appeared in various fields of culture. Hofmannsthal isalso one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna but his influence
reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extractthe essence of the modern culture in the German-language area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Halfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen wie sie der Historiker Reinharｔ Kosellecｋ die ？Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte mochte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen mochte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen
HONDA:It is inquiring about the ethics of technology. Tradition of knowledge" has considered the problem what kind of
responsibility occurs why in possible one and the side which inherits knowledge again by the mainly phenomenological
technique.
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here Japanese) influence the pronunciation of-102-

Japanese speakers of English is studied, Japanese) influence the pronunciation of Japanese speakers of English is studied.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the English found in medical articles to determine themost commonly used words forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.
Tsuda:Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition our
research focuses on improvement of physical fitness through soccer in PE classes for children.

Publications
Originals
8620B001

R.Tsuda, H.Suzuki:Results of a soccer teaching program intended to help students improve and acquire knowledgeof physical fitness, Japan Journal of Physical Education, Health and Sport Sciences, 61:257-270, 2016.

8620B002(Y.Sawae), Y.Murakami:The motor difficulties of school-aged children with developmental disabilities, Japanese
Journal of Clinical Developmental Psychology, 11:21-26, 2016.

Presentations at Conference
International Conference (Presentations)
8620I001

R.Tsuda:Load characteristics of soccer games in PE classes from the viewpoint of improvement in physical fitness,
21th annual Congress of the European College of Sport Science (ECSS), Vienna, 2016.

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University Hospital

0635

Hepatology

Faculty
Title

Name

Field of Specialization

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Associate Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Associate Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Senior Assistant Professor

SAITO Takashi

Treament for metabolic syndrome

Senior Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

MATSUE Yasuhiro

Mechanism of liver cancer

Assistant Professor

MINATO Takahiro

Mechanism of non-alcoholic steatohepatitis

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Hepatic support system for severe alcoholic hepatitis③Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver
３ Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0635B001

K.Tamura, N.Hayashi, J.George, M.Toshikuni, T.Arisawa, J.Hiratake, M.Tsuchishima, M.Tsutsumi:GGsTop, anovel and specific γ-glutamyl transpeptidase inhibitor, protects hepatic ischemia-reperfusion injury in rats.,
American journal of physiology. Gastrointestinal and liver physiology, 311:2;Ｇ305-Ｇ312, 2016.

-104-

0635B002

N.Toshikuni, Y.Takuma, M.Tsutsumi:Management of gastroesophageal varices in cirrhotic patients: current status
and future directions., Annals of hepatology, 15:3;314-325, 2016.

0635B003

N.Toshikuni, Y.Matsue,T.Minato, N.Hayashi, M.Tsutsumi:Association between transforming growth factor-β1509 Ｃ＞Ｔ variants and hepatocellular carcinoma susceptibility: a meta-analysis, Neoplasma, 63:6;961-966, 2016.

0635B004(S.Sueyoshi), S.Sawai, M.Satoh, M.Seimiya, K.Sogawa, A.Fukumura, M.Tsutsumi, F.Nomura:Fractionation of
gamma-glutamyltransferase in patients with nonalcoholic fatty liver disease and alcoholic liver disease, World
journal of hepatology, 8:36;1610-1616, 2016.

0635B005(N.Kawada), H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita:Mural nodule of 10 mm or larger as
predictor of malignancy for intraductal papillary mucinous neoplasm of the pancreas: Pathological and radiologicalevaluations, Pancreatology, 16:3;441-448, 2016.

Presentations at Conference
International Conference (Presentations)
0635I001

N.Toshikuni, Y.Matsue, T.Minato, N.Hayashi, M.Tsuchishima, M.Tsutsumi:Association between transforming
growth factor-β1-509 C>T variants and hepatocellular carcinoma susceptibility: A meta-analysis, APDW2016,
Kobe, 2016.

-105-

0675

Health Evaluation Center

Faculty
Title

Name

Field of Specialization

Professor

ASAJI Takayoshi

Heartfailure

Professor(Additional Post)

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

NAKANISHI Yumiko

Preventive medicine

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Assistant Professor

ISHIKAWA Kaori

Preventive medicine

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Associate Professor(Additional Post)
Senior Assistant Professor(Additional Post)

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

0675B002(T.Koyama), K.Yoshita, M.Sakurai, K.Miura, Y.Naruse, N.Okuda, A.Okayama, J.Stamler, H.Ueshima,
H.Nakagawa:Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to thePrevention of Nutrient Deficiency: The INTERMAP Toyama Study, Journal of Nutritional Science andVitaminology, 62:2;101-107, 2016.

0675B003

M.Sakurai, J.Kobayashi, Y.Takeda, S.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi, H.Nakagawa:Sex Differences in
Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women,
Journal of Epidemiology, 26:8;440-446, 2016.

0675B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men, Journal of diabetes investigation, 7:3;343-351,
2016.

0675B005(Y.Isobe), M.Sakurai, Y.Kita, Y.Takeshita, H.Misu, S.Kaneko, T.Takamura:Fat-free mass and calf circumference asbody composition indices to determine non-exercise activity thermogenesis in patients with diabetes, Journal of
Diabetes Investigation, 7:3;352-358, 2016.

-106-

0675B006(H.Nakashima), K.Homma, M.Yamazaki, M.Ishizaki, K.Mawatari:Database analysis of acidic proteins from halophilic
halophilic species and their corresponding basic proteins from non-halophilic species, British Biotechnology
Journal, 14:2;1-12, 2016.

0675B007(D.Van Tung), T.Kido, S.Honma, HD.Manh, DD.Nhu, R.Okamoto, S.Maruzeni, M.Nishijo, H.Nakagawa, PT.Ngoc,
N.Van Toan, NN.Hung, NH.Minh, K.Son Le:Low birth weight of Vietnamese infants is related to their mother's
dioxin and glucocorticoid levels, Environmental science and pollution research international, 23:11;10922-10929,
2016.

0675B008(XL.Sun), T.Kido, S.Honma, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, T.Nakano, E.Koh,
T.Takasuga, DD.Nhu, NN.Hung, K.Son Le:Influence of dioxin exposure upon levels of prostate-specific antigen
and steroid hormones in Vietnamese men, Environmental science and pollution research international, 23:8;78077813, 2016.

0675B009

PT.Tai, M.Nishijo, TN.Nghi, H.Nakagawa. H.Van Luong, TH.Anh, H.Nishijo:Effects of Perinatal Dioxin Exposureon Development of Children during the First 3 Years of Life., The Journal of pediatrics, 175:159-166, 2016.

0675B010(K.Nakamura), M.Sakurai, Y.Morikawa, S.Nagasawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa:Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective
Study in Normoglycemic Japanese Men, Experimental and clinical endocrinology & diabetes : official journal,
German Society of Endocrinology [and] German Diabetes Association, 25:1;12-20, 2016.

0675B011

Tran Nghi Ngoc, Pham Tai The, K.Ozawa, M.Nishijo, Nguyen Anh Thi Nguyet; Tran Tuong Quy, Hoang Luong
Van, Tran Anh Hai, Phan Vu Huy Anh, A.Nakai, Y.Nishino, H.Nishijo:Impacts of Perinatal Dioxin Exposure on
Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year FollowUp., PLOS ONE, 11:1;e0147655, 2016.

0675B012(S.Virani), KM.Rentschler, M.Nishijo, W.Ruangyuttikarn, W.Swaddiwudhipong, N.Basu, LS.Rozek:DNA methylation
is differentially associated with environmental cadmium exposure based on sex and smoking status, Chemosphere,
145:284-290, 2016.

0675B013

C.Chen, P.Xun, M.Nishijo, S.Carter, K.He:Cadmium exposure and risk of prostate cancer: a meta-analysis ofcohort and case-control studies among the general and occupational populations, Scientific reports, 6:25814, 2016.

0675B014(K.Sai), K.Kajinami, H.Akao, M.Iwadare, R.Sato-Ishida, Y.Kawai, K.Takeda, T.Tanimoto, T.Yamano, T.Akasaka,
T.Ishida, K.Hirata, K.Saku, S.Yagi, T.Soeki, M.Sata, M.Ueno, S.Miyazaki, A.Shiraki, J.Oyama, K.Node,
K.Sugamura, H.Ogawa, K.Kurose, K.Maekawa, Y.Matsuzawa, T.Imatoh, R.Hasegawa, Y.Saito:A possible role for
HLA-DRB1*04:06 in statin-related myopathy in Japanese patients, Drug metabolism and pharmacokinetics,
31:6;467-470, 2016.

0675B015

Y.Hamazaki, Y.Morikawa, S.Morimoto, H.Nakagawa:Difference in the impact of homebound status on functional
decline between independent older men and women: A 2 year follow-up study., Japan journal of nursing science,
13:2;265-272, 2016.

Reviews
0675C001

M.Sakurai:Effect of artificial sweeteners on glucose metabolism, Journal of the Japan Diabetes Society, 59:1;33-35,
2016.

0675C002(C.Chen), P.Xun, M.Nishijo, K.He:Cadmium exposure and risk of lung cancer: a meta-analysis of cohort and casecontrol studies among general and occupational populations, Journal of exposure science & environmental
epidemiology, 26:5;437-444, 2016.

Presentations at Conference
International Conference (Key Note Lecture)
0675G001

M.Nishijo, PN.Nghi, PT.Tai, H.Nishijo, Y.Nishino:Role of AHR signaling in effects on neurodevelopment in
Vietnamese children perinatelly exposed to Agent Orange, AHR2016 The aryl hydrocarbon Receptor as a Central
Mediator of Health and Disease, Rochester, 2016.

-107-

International Conference (Presentations)
0675I001

Y.Matsuda, R.Hashimoto, S.Takemoto, M.Ishizaki, Y.Kawasaki:A Dementia Screening Investigation for Inhabitantsof Rural Areas in Japan, The 2016 Alzheimer's Disease Congress, London, 2016.

0675I002

M.Nishijo, PN.Thao, PT.Tai, T.Anh, H.Boda, S.Nagasawa, Y.Nishino, H.Nishijo:Neurotoxic effects of perinatal
dioxin exposure on children in Vietnam:Two birth cohort studiies in hot spots of dioxin contamination from Agent
Orange, PPToxⅤ, Kitakyusyu, 2016.

0675I003

PN.Thao, M.Nishijo, PT.Tai, H.Nishijo, S.Nagasawa, Y.Nishino:A case control study of neurotoxic effects ofperinatal dioxin exposure on children of 2years of age in Vietnam, PPToxⅤ, Kitakyusyu, 2016.

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Medical Research Institute7100

Department of Life Sciences

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor

IWAWAKI Takao

Cellular stress response

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

TASAKI Takafumi

Protein regulation by the post-translational modifications and its
underlying molecular mechanisms

Senior Assistant Professor

OHTSUKA Satoshi

Stem Cell Biology

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Senior Assistant Professor

TANIGUCHI Makoto

Molecular and Cellular Biology, Lipid Biochemistry

Assistant Professor

TATSUNO Takanori

Molecular biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy, protein quality control, gene
expression control, homeostatic regulation, biological defense system, molecular imaging

Outline of Research
１．Study on viral replication and pathogenicity
２．Molecular mechanism of carcinogenesis and metastasis
３．Research on plolyploidization and polyploid cells
４．Analyses of transcription and mRNA decay
５．Protein regulation by the post-translational modifications and its underlying molecular mechanisms
６．Lipid metabolism and its-associated diseases
７．Stem cell biology and development
８．Physiological and pathological function of cellular stress response

Publications
Originals
7100B001(T.Ohba), M.Ishisaka, S.Tsujii, K.Tsuruma, M.Shimazawa, K.Kubo, N.Umigai, T.Iwawaki, H.Hara:Crocetin protects
ultraviolet A-induced oxidative stress and cell death in skin in vitro and in vivo., European journal ofpharmacology, 789:244-253, 2016.

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7100B002(M. Fujiwara), M. Okamoto, M. Hori, H. Suga, Hi. Jikihara, Y. Sugihara, F. Shimamoto, T. Mori, K. Nakaoji, K.
Hamada, T. Ota, R. Wiedemuth, A. Temme, M. Tatsuka:Radiation-Induced RhoGDIβ Cleavage Leads to
Perturbation of Cell Polarity: A Possible Link to Cancer Spreading., Journal of cellular physiology, 231:11;24932505, 2016.

7100B003(K.Tazaki), F.Tazaki, M.Okuno, T.Takehara, Y.Ishigaki, H.Nakagawa:Formation of Pisoliths at Hot Springs inSaturnia, Toscana, Italy, The Journal of the Geological Society of Japan, 122:2;45-60, 2016.

7100B004(Y.Omata), Tharasegaran Suganya, Lim Young-Mi, Y.Yamasaki, Y.Ishigaki, T.Tatsuno, M.Maruyama,
L.Tsuda:Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in highfrequency sound perception., Aging(Albany NY), 8:3;1-14, 2016.

7100B005

T.Tatsuno, Y.Nakamura, Ma Shaofu, N.Tomosugi, Y.Ishigaki:Nonsense-mediated mRNA decay factor Upf2 exists inboth the nucleoplasm and the cytoplasm., Molecular medicine reports, 14:1;655-660, 2016.

7100B006(H.Niwa), A.Nakamura, M.Urata, M.Shirae-Kurabayashi, S.Kuraku, Russell Steven, S.Ohtsuka:The evolutionallyconserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells, BMC
evolutionary biology, 16:1-12, 2016.

7100B007(S.Nukuzuma), K.Nakamichi, M.Kameoka, S.Sugiura, C.Nukuzuma, T.Tasaki, T.Takegami:Suppressive effect of
topoisomerase inhibitors on JC polyomavirus propagation in human neuroblastoma cells, Microbiology and
Immunology, 60:4;253-260, 2016.

7100B008(M.Wu), M.Takemoto, M.Taniguchi, T.Takumi, T.Okazaki, W.J.Song:Regulation of membrane KCNQ1/KCNE1
channel density by sphingomyelin synthase 1, American Journal of Physiology Cell Physiology, 311:C15-C23,
2016.

7100B009

M.Taniguchi, T.Tasaki, H.Ninomiya, Y.Ueda, K.Kuremoto, S.Mitsutake, Y.Igarashi, T.Okazaki,
T.Takegami:Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection withJapanese encephalitis virus, Scientific Reports, 6:37829, 2016.

7100B010

J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato:Learning impairment byminimal cortical injury in a mouse model of Alzheimer's disease., Brain research, 1637:56-63, 2016.

7100B011

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

7100B012(K.Higashi), T.Yamagishi, Y.Ueda, Y.Ishigaki, M.Shimasaki, Y.Nakamura, M.Oguchi, T.Takegami, M.Sagawa,
H.Tonami:Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma., Annals of
nuclear medicine, 30:10;708-715, 2016.

7100B013

M.Murakami, T.Tasaki, S.Nukuzuma, H.Minato, T.Nojima, Y.Ishigaki, T.Takegami:Japanese encephalitis virus
replication and inhibitory effect of shRNA in mice, Advances in Microbiology, 6:6;462-470, 2016.

7100B014

S.P.Srivastava, S.Shi, M.Kanasaki, T.Nagai, M.Kitada, J.He, Y.Nakamura, Y.Ishigaki, K.Kanasaki, D.Koya:Effect of
Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related
Kidney Fibrosis., Scientific reports, 6:29884, 2016.

7100B015

Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara,
H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta,
N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita,
S.Aoki:Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome,2015 version., International journal of hematology, 103:6;686-692, 2016.

7100B016

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki:Proposed diagnostic criteria, disease severity classification, and treatment strategy for a novel
disorder; TAFRO syndrome., The Japanese journal of clinical hematology, 57:10;2029-2037, 2016.

7100B017

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki, Japanese TAFRO syndrome research team:Proposed diagnostic criteria, disease severity
classification, and tretment strategy for a novel disorder;TAFRO syndrome, The Japanese Journal of Clinical
Hematology, 57:10;195-203, 2016.

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Reviews
7100C001 T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto: Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

Short Communications
7100E001(T.Kiba), Y.Ishiagaki:Ventromedial hypothalamic lesions Dowm-Reguiate the Expression of Adora1 Genes in rat
Pancreatic islets, LETTERS TO THE EDITOR, 45:1;e1-e2, 2016.

7100E002

T.Tasaki, S. Nukuzuma, T. Takegami:Impaired Japanese encephalitis virus replication in p62/SQSTM1 deficientmouse embryonic fibroblasts, Microbiology and Immunology, 60:10;708-711, 2016.

Presentations at Conference
International Conference (Presentations)
7100I001

D.Nakai, S.Inoue, Y.Nakazawa, N.Morita, K.Miyazawa, Y.Ishigaki:Febuxostat reduces calcium oxalate monohydrate
crystal-induced upregulation of MCP-1 in MDCK cells, 13th International Symposium on Urolithiasis, Makuhari,
2016.

7100I002(L.Liu), M.Zhao, X.Jin, K.Yang, G.Ney, JD.Valle, T.Iwawaki, Q.Li:N-rasG12D/+-mediated dysregulation of
IRE1alpha-Xbp1 UPR pathway promotes pre-leukemic hematopoietic stem cell expansion, The 58th Annual
Meeting of the American Society of Hematology, San Diego, 2016.

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7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Associate Professor

NIIDA Yo

Genetic disease, Genetic diagnosis

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

SAKASAI Akiko

AGEs, Cell Biology

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype,

Outline of Research
１．Heart failure by autoimmune pathway related with G-protein
２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
３．The role of AGE in the prevention of lifestyle related disease
４．Clinical research for the diagnosis and treatment of pancreatic cancer
５．Development and clinical application of fetal DNA diagnosis using mother’s blood
６．Genetic diagnosis and analysis of hereditary developmental disability
７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Publications
Originals
7200B001(T.Munesue), H.Nakamura, M.Kikuchi, Y.Miura, N.Takeuchi, T.Anme, E.Nanba, K.Adachi, K.Tsubouchi, Y.Sai,
K.Miyamoto, S.Horike, S.Yokoyama, H.Nakatani, Y.Niida, H.Kosaka, Y.Minabe, H.Higashida:Oxytocin for malesubjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study, Frontiersin psychiatry, 7:1-11, 2016.

7200B002

Y.Niida, H.Sato, M.Ozaki, M.Itoh, K.Ikeno, E.Takase:Angelman Syndrome Caused by Chromosomal
Rearrangements: A Case Report of 46,XX,+der(13)t(13;15)(q14.1;q12)mat,-15 with an Atypical Phenotype andReview of the Literature, Cytogenetic and genome research, 149:247-257, 2016.

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7200B003(M.Shimomura), J.Oyama, M.Takeuchi, Y.Shibata, Y.Yamamoto, T.Kawasaki, H.Komoda, K.Kodama, M.Sakuma,
S.Toyoda, Y.Inoue, Mine Daigo, M.Natsuaki, A.Komatsu, Y.Hikichi, S.Yamagishi, T.Inoue , K.Node:Acute effectsof statin on reduction of angiopoietin-like 2 and glyceraldehyde-derived advanced glycation end-products levels inpatients with acute myocardial infarction: a message from SAMIT (Statin for Acute Myocardial Infarction Trial).,Heart and vessels, 31:10;1583-1589, 2016.

7200B004(K.Kitatani), T.Usui, SK.Sriraman, M.Toyoshima, M.Ishibashi, S.Shigeta, S.Nagase, M.Sakamoto, H.Ogiso,
T.Okazaki, YA.Hannun, VP.Torchilin, N.Yaegashi:Ceramide limits phosphatidylinositol-3-kinase C2β-controlledcell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid, Oncogene, 35:21;28012812, 2016.

7200B005(H.Watanabe), K.Okahara, Y.Naito-Matsui, M.Abe, S.Go, J.Inokuchi, T.Okazaki, T.Kobayashi, Y.Kozutsumi,
S.Oka, H.Takematsu:Psychosine-triggered endomitosis is modulated by membrane sphingolipids through regulationof phosphoinositide 4,5-bisphosphate production at the cleavage furrow., Molecular biology of the cell,
27:13;2037-2050, 2016.

7200B006

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

7200B007

M.Itoh, Y.Kittaka, Y.Niida, Y.Saikawa:A novel frameshift mutation in the TRPS1 gene caused Tricho-rhinophalangeal syndrome type I and III in a Japanese family, Clinical pediatric endocrinology : case reports and clinicalinvestigations : official journal of the Japanese Society for Pediatric Endocrinology, 25:3;115-118, 2016.

7200B008

T.Tatsuno, Y.Nakamura, Ma Shaofu, N.Tomosugi, Y.Ishigaki:Nonsense-mediated mRNA decay factor Upf2 exists inboth the nucleoplasm and the cytoplasm., Molecular medicine reports, 14:1;655-660, 2016.

7200B009

Y.Fujita, T.Fujii, H.Shimizu, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka,
Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara, T.Mimori:Isolation of vascular smooth muscle antigen-reactive
CD4(+)αβTh1 clones that induce pulmonary vasculitis in MRL/Mp-Fas(+/+) mice., Cellular immunology, 303:5054, 2016.

7200B010

H.Yoshizaki, H.Ogiso, T.Okazaki, E.Kiyokawa:Comparative lipid analysis in the normal and cancerous organoids of
MDCK cells., Journal of Biochemistry, 159:6;573-584, 2016.

7200B011(M.Wu), M.Takemoto, M.Taniguchi, T.Takumi, T.Okazaki, W.J.Song:Regulation of membrane KCNQ1/KCNE1
channel density by sphingomyelin synthase 1, American Journal of Physiology Cell Physiology, 311:C15-C23,
2016.

7200B012

M.Taniguchi, T.Tasaki, H.Ninomiya, Y.Ueda, K.Kuremoto, S.Mitsutake, Y.Igarashi, T.Okazaki,
T.Takegami:Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection withJapanese encephalitis virus, Scientific Reports, 6:37829, 2016.

7200B013(LN.van der Vorm), JC.Hendriks, CM.Laarakkers, S.Klaver, AE.Armitage, A.Bamberg, AJ.Geurts-Moespot,
D.Girelli, M.Herkert, O.Itkonen, RJ.Konrad, N.Tomosugi, M.Westerman, SS.Bansal, N.Campostrini,
H.Drakesmith, M.Fillet, G.Olbina, SR.Pasricha, KR.Pitts, JHSloan, F.Tagliaro, CW.Weykamp, DW.Swinkels:
Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material,
Clinical chemistry, 62;993-1001,2016.

7200B014(H.Honda) , Y.Kobayashi, S.Onuma, K.Shibagaki, T.Yuza, K.Hirao, T. Yamamoto, N.Tomosugi, T.Shibata:
Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with
Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis, PLoS One, 11;e0151601,2016.

Reviews
7200C001

M.Takeuchi:Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progressionof Lifestyle-Related Diseases, Diagnostics, 6:2;1-22, 2016.

7200C002

T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto:Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

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7200C003(T.Domoto), Pyko Ilya V, T.Furuta, K.Miyashita, M.Uehara, T.Shimasaki, M.Nakada, T.Minamoto:Glycogensynthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy., Cancer science,
107:10;1363-1372, 2016.

7200C004(DJ.Klionsky), D.Koya, T.Okazaki et al.:Guidelines for the use and interpretation of assays for monitoring
autophagy (3rd edition)., Autophagy, 12:1;1-222, 2016.

7200C005

Y.Motoo:How long should cancer chemotherapy be continued?-Form the viewpoint of duration of efficacy ofmolecular targeting drugs, Japanese Journal of Cancer and Chemotherapy, 43:7;819-823, 2016.

Case Reports
7200D001

Y.Niida, A.Yokoi, M.Kuroda, Y.Mitani, H.Nakagawa, M.Ozaki:A girl with infantile neuronal ceroid lipofuscinosis
caused by novel PPT1 mutation and paternal uniparental isodisomy of chromosome 1., Brain & development,
38:7;674-677, 2016.

7200D002

Y.Niida, Y.Mitani, M.Kuroda, A.Yokoi, H.Nakagawa, A.Kato:A Say-Barber-Biesecker-Young-Simpson variant of
Ohdo syndrome with a KAT6B 10-base pair palindromic duplication: a recurrent mutation causing a severe
phenotype mixed with genitopatellar syndrome, Congenital anomalies, 1:1-9, 2016.

7200D003

Y.Yasui, M.Kohno, S.Nishida, T.Shironomae, M.Satomi, T.Kuwahara, S.Takahashi, Y.Niida:Cartilage-hairhypoplasia associated with isolated hypoganglionosis: A case report., Congenital anomalies, 52:32-34, 2016.

7200D004(N.Yamakawa), K.Oe, N.Yukawa, K.Murakami, R.Nakashima, Y.Imura, H.Yoshifuji, K.Ohmura, Y.Miura,
N.Tomosugi, H.Kawabata, A.Takaori-Kondo, T.Mimori:

Short Communications
7200E001

Y.Niida, A.Yokoi, M.Kuroda, Y.Mitani, H.Nakagawa, M.Ozaki:Reply to: Uniparental disomy of chromosome 1
unmasks recessive mutations of PPT1 in a boy with neuronal ceroid lipofuscinosis type 1, Brain & development,
39:2;184-185, 2016.

Presentations at Conference
International Conference (Presentations)
7200I001

Y.Niida, M.Ozaki, A.Wakisaka, T.Tsuji, M.Kuroda, Y.Mitani, A.Yokoi:Mutational Analysis of TSC1 and TSC2 in
Japanese Patients with Tuberous Sclerosis Complex Revealed Higher Incidence of TSC1 Patients than Previously
Reported and unique TSC1 mutational pool, 13th International Congress of Human Genetics, Kyoto, 2016.

7200I002

M.Ozaki, Y.Niida, E.Takase, Y.Ito, H.Sato, T.Ikeda:Visualization of Cytogenetic Testing in Clinical Genetics, 13th
International Congress of Human Genetics, Kyoto, 2016.

7200I003

T.Arisawa, M.Ota, T.Tahara, J.Wu, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:A
polymorphisms of DNMT3A gene is clisely associated with the severity of gastric mucosal atrophy, APDW2016,
Kobe, 2016.

7200I004

J.Wu, T.Arisawa, T.Tahara, M.Ota, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:The
association between genetic polymorphisms of DNMT3A(rs6733868 and rs13428812)and the susceptibility to thegastric cancer in japan, APDW2016, Kobe, 2016.

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7310

Division of Innovative Research

Title

Name

Field of Specialization

Professor(Additional Post)

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, Enviromental health sciences,
Epidemiology of cadmium pollution

Faculty

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products,

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. Cellular and molecular mechanisms in angiogenesis

Publications
Originals
7310B001(D.Van Tung), T.Kido, S.Honma, HD.Manh, DD.Nhu, R.Okamoto, S.Maruzeni, M.Nishijo, H.Nakagawa, PT.Ngoc,
N.Van Toan, NN.Hung, NH.Minh, K.Son Le:Low birth weight of Vietnamese infants is related to their mother's
dioxin and glucocorticoid levels, Environmental science and pollution research international, 23:11;10922-10929,
2016.

7310B002(XL.Sun), T.Kido, S.Honma, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, T.Nakano, E.Koh,
T.Takasuga, DD.Nhu, NN.Hung, K.Son Le:Influence of dioxin exposure upon levels of prostate-specific antigen
and steroid hormones in Vietnamese men, Environmental science and pollution research international, 23:8;78077813, 2016.

7310B003

PT.Tai, M.Nishijo, TN.Nghi, H.Nakagawa. H.Van Luong, TH.Anh, H.Nishijo:Effects of Perinatal Dioxin Exposureon Development of Children during the First 3 Years of Life., The Journal of pediatrics, 175:159-166, 2016.

7310B004

Tran Nghi Ngoc, Pham Tai The, K.Ozawa, M.Nishijo, Nguyen Anh Thi Nguyet; Tran Tuong Quy, Hoang Luong
Van, Tran Anh Hai, Phan Vu Huy Anh, A.Nakai, Y.Nishino, H.Nishijo:Impacts of Perinatal Dioxin Exposure on
Motor Coordination and Higher Cognitive Development in Vietnamese Preschool Children: A Five-Year FollowUp., PLOS ONE, 11:1;e0147655, 2016.

7310B005(S.Virani), KM.Rentschler, M.Nishijo, W.Ruangyuttikarn, W.Swaddiwudhipong, N.Basu, LS.Rozek:DNA methylation
is differentially associated with environmental cadmium exposure based on sex and smoking status, Chemosphere,
145:284-290, 2016.

7310B006(C.Chen), P.Xun, M.Nishijo, S.Carter, K.He:Cadmium exposure and risk of prostate cancer: a meta-analysis ofcohort and case-control studies among the general and occupational populations, Scientific reports, 6:25814, 2016.

7310B007

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

7310B008(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

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Reviews
7310C001(C.Chen), P.Xun, M.Nishijo, K.He:Cadmium exposure and risk of lung cancer: a meta-analysis of cohort and casecontrol studies among general and occupational populations, Journal of exposure science & environmental
epidemiology, 26:5;437-444, 2016.

Presentations at Conference
International Conference (Key Note Lecture)
7310G001

M.Nishijo, PN.Nghi, PT.Tai, H.Nishijo, Y.Nishino:Role of AHR signaling in effects on neurodevelopment in
Vietnamese children perinatelly exposed to Agent Orange, AHR2016 The aryl hydrocarbon Receptor as a Central
Mediator of Health and Disease, Rochester, 2016.

International Conference (Presentations)
7310I001

M.Nishijo, PN.Thao, PT.Tai, T.Anh, H.Boda, S.Nagasawa, Y.Nishino, H.Nishijo:Neurotoxic effects of perinatal
dioxin exposure on children in Vietnam:Two birth cohort studiies in hot spots of dioxin contamination from Agent
Orange, PPToxⅤ, Kitakyusyu, 2016.

7310I002

PN.Thao, M.Nishijo, PT.Tai, H.Nishijo, S.Nagasawa, Y.Nishino:A case control study of neurotoxic effects ofperinatal dioxin exposure on children of 2years of age in Vietnam, PPToxⅤ, Kitakyusyu, 2016.

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7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Assistant Professor(Additional Post)

HATSUSAKA Natsuko ophthalmological optics

Keywords of Research
electromagnetic waves, ultraviolet rays, radioactive rays, cataract, pterygium, pinguecula.

Outline of ResearchThis research division studies environmental effects on incidence of ocular diseases. In quantitative studies of radio
frequency (RF) electromagnetic spectrum effects on eyes, ocular effects from exposure to wavelengths encountered in daily
life are examined by experimentation on rabbit eyes. Research on ocular exposure to ultraviolet (UV) wavelengths utilizes ahuman like mannequin equipped with UV sensors, and evaluates the efficacy of sunglasses, eye glasses and otheraccessories in offering eye protection against harmful exposure.
Our longitudinal epidemiological studies on eyes in Japan (Ishikawa) and Iceland, epidemiological surveys on blindness and
UV-related eye disease in Tanzania, and ocular epidemiological studies in domestic and international regions with different
climate conditions were conducted to investigate and analyze associations among ocular UV exposure and cataract,pterygium, and pinguecula. In our epidemiological study on UV-related ocular diseases targeting Japanese and Taiwanesechildren, the effects of ocular UV exposure in childhood are examined.
In 2013, a longitudinal study on radiation exposure dose and incidence of lens opacity in emergency workers of TEPCO
Fukushima Daiichi Nuclear Power Plant was commenced and is envisaged to include approximately 20,000 subjects.

Publications
Originals
7320B001

M.Fukuda, H.Sasaki:In vivo meaurement of human corneal impedance value, Cornea, 35:1305-1307, 2016.

7320B002

M.Fukuda, N.Takeda, S.Shibata, N.Shibata, T.Shibata, K.Sugiyama, H.Sasaki:In vitro and in vivo corneal effects oflatanoprost combined with brimonidine, timolol, dorzolamide, or brinzolamide, European Journal of Pharmacology,
787:43-46, 2016.

7320B003

T.Shibata, Y.Takahashi, A.Okamoto, H.Sasaki, K.Kitagawa:An adult case of fulminant mumps keratitis withpositive viral RNA in aqueous humor detected by RT-PCR, Cornea, 35:569-571, 2016.

7320B004

S.Shibata, N.Shibata, T.Shibata, H.Sasaki, DP.Singh, E.Kubo:The role of Prdx6 in the protection of cell of thecrystalline lens from oxidative stress induced by UV exposure, Japanese Journal of Ophthalmology, 60:408-418,
2016.

7320B005

T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:Propolis, a constituent of honey, inhibits
the development of sugar cataracts and high-glucose-induced reactive oxygen species in rat lenses, Journal of
Ophthalmology, 2016;1917093, 2016.

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Presentations at Conference
International Conference (Presentations)
7320I001(Y.Suzuki), M.Kojima, J.Chakarothai, K.Sasaki, M.Taki, H.Sasaki:Investigation on corneal epithelium damage
thresholds by CEM43℃ criterion due to millimeter-wave electromagnetic field exposure, The Association for
Research in Vision and Ophthalmology 2016, Seattle, 2016.

7320I002

S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Age-related cataract and expression level ofdecorin in human eye: association with opacity severity, The Association for Research in Vision and Ophthalmology
2016, Seattle, 2016.

7320I003

H.Sasaki, M.Kita, H.Miyashita, N.Tanimura, H.Osada, T.Shibata, Y.Takahashi, S.Shibata, E.Kubo:Influence of age
on visual function of eyes with cataract, The Association for Research in Vision and Ophthalmology 2016, Seattle,
2016.

7320I004

E.Kubo, T.Shibata, S.Shibata, H.Sasaki, E.Kiyokawa, M.Ikawa, DP.Singh:Knock-down of Tropomyosin 2 created by
CRISPR-CAS9 in mouse induces age-related-cataract, The Association for Research in Vision and Ophthalmology
2016, Seattle, 2016.

7320I005

N.Tanimura, E.Shibuya, M.Kita, A.Okamoto, N.Mita, N.Hatsusaka, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Visualfunction of eyes with waterclefts, The Association for Research in Vision and Ophthalmology 2016, Seattle, 2016.

7320I006

H.Miyashita, H.Osada, E.Shibuya, N.Tanimura, T.Shibata, S.Shibata, K.Sasaki, E.Kubo, H.Sasaki:Evaluation ofwaterclefts by anterior segment OCT, The Association for Research in Vision and Ophthalmology 2016, Seattle,
2016.

7320I007

H.Sasaki, E.Shibuya, M.Sasaki, M.Kita, H.Osada, N.Shibata, E.Kubo:Posterior capsular wrinkles in eyes with 1piece intraocular lens, ESCRS Annual Congress 2016, Copenhagen, 2016.

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7340

Division of Anticipatory Molecular Food Science and Technology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOYA Daisuke

diabetes, hypertension, obesity, aging

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Associate Professor(Additional Post)
Associate Professor(Additional Post)

Publications
Originals
7340B001

S.Shi, K.Kanasaki, D.Koya:Linagliptin but not sitagliptin inhibited transforming growth factor-β2-induced
endothelial DPP-4 activity and the endothelial-mesenchymal transition., Biochemical and biophysical researchcommunications, 471:1;184-190, 2016.

7340B002(A.Tagawa), M.Yasuda, S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya,
K.Asanuma, EH.Kim, M.Haneda, N.Kajiwara, K.Hayashi, H.Ohashi, S.Ugi, H.Maegawa, T.Uzu:Impaired podocyte
autophagy exacerbates proteinuria in diabetic nephropathy., Diabetes, 65:3;755-767, 2016.

7340B003

K.Nitta, Shi Sen, T.Nagai, M.Kanasaki, M.Kitada, Srivastava Swayam Prakash, M.Haneda, K.Kanasaki,
D.Koya:Oral administration of N-acetyl-seryl-aspartyl-lysyl-proline ameliorates kidney disease in both type 1 andtype 2 diabetic mice via a therapeutic regimen., BioMed research international, 2016:9172157, 2016.

7340B004

M.Kitada, Y.Ogura, T.Suzuki, S.Sen, S.M.Lee, K.Kanasaki, S.Kume, D.Koya:A very-low-protein diet ameliorates
advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar
fatty rats, an animal model of type 2 diabetes and obesity., Diabetologia, 59:6;1307-1317, 2016.

7340B005

S.P.Srivastava, S.Shi, M.Kanasaki, T.Nagai, M.Kitada, J.He, Y.Nakamura, Y.Ishigaki, K.Kanasaki, D.Koya:Effect of
antifibrotic microRNAs crosstalk on the action of N-acetyl-seryl-aspartyl-lysyl-proline in diabetes-related kidney
fibrosis., Scientific reports, 6:29884, 2016.

7340B006(K.Ueshima), H.Itoh, N.Kanazawa, I.Komuro, R.Nagai, M.Takeuchi, T.Yamazaki, EMPATHY study group, D.Koya,
A.Nakagawa, M.Nishizawa, M.Kitada, S.Tsuda, K.Konishi:Rationale and design of the standard versus intensive
statin therapy for hypercholesterolemic patients with diabetic retinopathy (EMPATHY) study: a randomized
controlled trial, 23:8;976-990, 2016.

7340B007(S.Kume), M.Kondo, S.Maeda, Y.Nishio, T.Yanagimachi, Y.Fujita, M.Haneda, K.Kondo, A.Sekine, S.Araki,
H.Araki, M.Chin-Kanasaki, S.Ugi, D.Koya, S.Kitahara, K.Maeda, A.Kashiwagi, T.Uzu, H.Maegawa:Hypothalamic
AMP-activated protein kinase regulates biphasic insulin secretion from pancreatic β cells during fasting and in
type 2 diabetes, EBioMedicine, 13:168-180, 2016.

7340B008(S.Kuwagata), S.Kume, M.Chin-Kanasaki, H.Araki, S.Araki, J.Nakazawa, T.Sugaya, D.Koya, M.Haneda,
H.Maegawa, T.Uzu:MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2
in proximal tubular cells., Kidney international, 90:6;1211-1225, 2016.

7340B009(T.Uzu), S.Araki, A.Kashiwagi, M.Haneda, D.Koya, H.Yokoyama, Y.Kida, M.Ikebuchi, T.Nakamura, M.Nishimura,
N.Takahara, T.Obata, N.Omichi, K.Sakamoto, R.Shingu, H.Taki, Y.Nagai, H.Tokuda, M.Kitada, M.Misawa,
A.Nishiyama, H.Kobori, H.Maegawa, The Shiga Committee for Preventing Diabetic Nephropathy:Comparative
effects of direct renin inhibitor and angiotensin receptor blocker on albuminuria in hypertensive patients with type2 diabetes. A randomized controlled trial, PLoS ONE, 11:e0164936, 2016.

-119-Reviews
7340C001

K.Kanasaki:The pathological significance of dipeptidyl peptidase-4 in endothelial cell homeostasis and kidney
fibrosis, Diabetology International, 7:3;212-220, 2016.

7340C002(DJ.Klionsky), D.Koya, T.Okazaki et al.:Guidelines for the use and interpretation of assays for monitoring
autophagy (3rd edition)., Autophagy, 12:1;1-222, 2016.

7340C003(A.Takagi), S.Kume, M.Kondo, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya, M.Haneda, T.Chano,
T.Matsusaka, K.Nagao, Y.Adachi, L.Chan, H.Maegawa, T.Uzu:Mammalian autophagy is essential for hepatic andrenal ketogenesis during starvation., Scientific reports, 6:18944, 2016.

7340C004

S.Shi, D.Koya, K.Kanasaki:Dipeptidyl peptidase-4 and kidney fibrosis in diabetes., Fibrogenesis & tissue repair,
9:1, 2016.

7340C005

M.Kitada, Y.Ogura, D.Koya:The protective role of sirt1 in vascular tissue: its relationship to vascular aging andatherosclerosis., Aging(Albany NY), 8:10;2290-2307, 2016.

7340C006

M.Kitada, Y.Ogura, D.Koya:Rodent models of diabetic nephropathy: their utility and limitations., International
journal of nephrology and renovascular disease, 9:279-290, 2016.

Case Reports
7340D001 S.Tsuda, K.Konishi, T.Otoda, T.Nagai, A.Takeda-Watanabe, M.Kanasaki, M.Kitada, A.Nakagawa, M.Nishizawa,
K.Kanasaki, D.Koya:Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2
Diabetes by Avoiding Chronic Hypoglycemia., Internal medicine, 55:23;3471-3473, 2016.
7340D002 (Y.Sasagawa), O.Tachibana, A.Nakagawa, S.Nakada, T.Nojima, D.Koya, H.Iizuka:Rapid enlargement of an
intracranial germ cell tumor after gonadotropin hormone therapy, JOURNAL OF CLINICAL NEUROSCIENCE,
31:185-188, 2016.

Short Communications
7340E001

K.Kanasaki:Concerted efforts to combat diabetic complications., Kidney international, 89:2;269-271, 2016.

7340E002

M.Kitada, Y.Ogura, D.Koya:The protective effect of a low-protein diet against tubulo-interstitial damage indiabetic kidneys, Cellular & Molecular Medicine: Open access, 2:2;6-7, 2016.

Presentations at Conference
International Conference (Presentations)
7340I001

O.Tachibana, Y.Sasagawa, A.Nakagawa, D.Koya, Y.Hayashi, M.Nakada, H.Iizuka:Expression of proinflammatory
cytokines and receptors in symptomatic Rathke cleft cysts - a possible mediator of secondary hypophysitis with
Rathke cleft cyst -, Euro-pit and 14th IPPC meeting in Annecy, Lyon, 2016.

7340I002(N.Ueki), S.Takeda, D.Koya, K.Kanasaki:Catechol-O-methyltransferase deficiency leads to hypersensitivity on thepressor response against angiotensin Ⅱ, American Society of Nephrology(KIDNEY WEEK 2016), Chicago, 2016.

7340I003(N.Ueki), A.Itakura, S.Takeda, K.Kanasaki:Catechol-O-methyltransferase deficiency leads to hypersensitivity on
the pressor response against angiotensin Ⅱ, 19th Congress of the Federation of Asia and Oceania Perinatal
Societies (FAOPS 2016), Taipei, 2016.

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7350

Division of Systems Bioscience for Drug Discovery Based on Intrinsically
Disordered Proteins

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)TOMOSUGI Naohisa

Clinical Proteomics

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Associate Professor(Additional Post)SHIMASAKI Takeo

Medical Oncology, Gastroenterology, Bioinformatics

Publications
Originals
7350B001(K.Tazaki), F.Tazaki, M.Okuno, T.Takehara, Y.Ishigaki, H.Nakagawa:Formation of Pisoliths at Hot Springs inSaturnia, Toscana, Italy, The Journal of the Geological Society of Japan, 122:2;45-60, 2016.

7350B002(Y.Omata), Tharasegaran Suganya, Lim Young-Mi, Y.Yamasaki, Y.Ishigaki, T.Tatsuno, M.Maruyama,
L.Tsuda:Expression of amyloid-β in mouse cochlear hair cells causes an early-onset auditory defect in highfrequency sound perception., Aging(Albany NY), 8:3;1-14, 2016.

7350B003

J.Zou, M.Wang, O.Uchiumi, Y.Shui, Y.Ishigaki, X.Liu, N.Tajima, T.Akai, H.Iizuka, N.Kato:Learning impairment byminimal cortical injury in a mouse model of Alzheimer's disease., Brain research, 1637:56-63, 2016.

7350B004

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

7350B005(K.Higashi), T.Yamagishi, Y.Ueda, Y.Ishigaki, M.Shimasaki, Y.Nakamura, M.Oguchi, T.Takegami, M.Sagawa,
H.Tonami:Correlation of HIF-1α/HIF-2α expression with FDG uptake in lung adenocarcinoma., Annals of
nuclear medicine, 30:10;708-715, 2016.

7350B006

M.Murakami, T.Tasaki, S.Nukuzuma, H.Minato, T.Nojima, Y.Ishigaki, T.Takegami:Japanese encephalitis virus
replication and inhibitory effect of shRNA in mice, Advances in Microbiology, 6:6;462-470, 2016.

7350B007

S.P.Srivastava, S.Shi, M.Kanasaki, T.Nagai, M.Kitada, J.He, Y.Nakamura, Y.Ishigaki, K.Kanasaki, D.Koya:Effect of
Antifibrotic MicroRNAs Crosstalk on the Action of N-acetyl-seryl-aspartyl-lysyl-proline in Diabetes-related
Kidney Fibrosis., Scientific reports, 6:29884, 2016.

7350B008

Y.Masaki, H.Kawabata, K.Takai, M.Kojima, N.Tsukamoto, Y.Ishigaki , N.Kurose, M.Ide, J.Murakami, K.Nara,
H.Yamamoto, Y.Ozawa, H.Takahashi, K.Miura, T.Miyauchi, S.Yoshida, A.Momoi, N.Awano, S.Ikushima, Y.Ohta,
N.Furuta, S.Fujimoto, H.Kawanami, T.Sakai, T.Kawanami, Y.Fujita, T.Fukushima, S.Nakamura, T.Kinoshita,
S.Aoki:Proposed diagnostic criteria, disease severity classification and treatment strategy for TAFRO syndrome,2015 version., International journal of hematology, 103:6;686-692, 2016.

7350B009

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki:Proposed diagnostic criteria, disease severity classification, and treatment strategy for a novel
disorder; TAFRO syndrome., The Japanese journal of clinical hematology, 57:10;2029-2037, 2016.

7350B010

Y.Masaki, H.Kawabata, K.Takai, N.Tsukamoto, S.Fujimoto, Y.Ishigaki, N.Kurose, M.Kojima, S.Nakamura,
T.Kinoshita, S.Aoki, Japanese TAFRO syndrome research team:Proposed diagnostic criteria, disease severity
classification, and tretment strategy for a novel disorder;TAFRO syndrome, The Japanese Journal of Clinical
Hematology, 57:10;195-203, 2016.

7350B011

T.Tatsuno, Y.Nakamura, Ma Shaofu, N.Tomosugi, Y.Ishigaki:Nonsense-mediated mRNA decay factor Upf2 exists inboth the nucleoplasm and the cytoplasm., Molecular medicine reports, 14:1;655-660, 2016.

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7350B012(LN.van der Vorm), JC.Hendriks, CM.Laarakkers, S.Klaver, AE.Armitage, A.Bamberg, AJ.Geurts-Moespot,
D.Girelli, M.Herkert, O.Itkonen, RJ.Konrad, N.Tomosugi, M.Westerman, SS.Bansal, N.Campostrini,
H.Drakesmith, M.Fillet, G.Olbina, SR.Pasricha, KR.Pitts, JHSloan, F.Tagliaro, CW.Weykamp, DW.Swinkels:
Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material,
Clinical chemistry, 62;993-1001,2016.

7350B013(H.Honda) , Y.Kobayashi, S.Onuma, K.Shibagaki, T.Yuza, K.Hirao, T. Yamamoto, N.Tomosugi, T.Shibata:
Associations among Erythroferrone and Biomarkers of Erythropoiesis and Iron Metabolism, and Treatment with
Long-Term Erythropoiesis-Stimulating Agents in Patients on Hemodialysis, PLoS One, 11;e0151601,2016.

Reviews
7350C001

T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto:Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

7350C002(T.Domoto), Pyko Ilya V, T.Furuta, K.Miyashita, M.Uehara, T.Shimasaki, M.Nakada, T.Minamoto:Glycogensynthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy., Cancer science,
107:10;1363-1372, 2016.
Case Reports

7350D001(N.Yamakawa), K.Oe, N.Yukawa, K.Murakami, R.Nakashima, Y.Imura, H.Yoshifuji, K.Ohmura, Y.Miura,
N.Tomosugi, H.Kawabata, A.Takaori-Kondo, T.Mimori: A Novel Phenotype of a Hereditary Hemochromatosis
Type 4 with Ferroportin-1 Mutation, Presenting with Juvenile Cataracts, Internal medicine, 55;2697-2701,2016.

Short Communications
7350E001(T.Kiba), Y.Ishiagaki:Ventromedial hypothalamic lesions Dowm-Reguiate the Expression of Adora1 Genes in rat
Pancreatic islets, LETTERS TO THE EDITOR, 45:1;e1-e2, 2016.

Presentations at Conference
International Conference (Presentations)
7350I001

D.Nakai, S.Inoue, Y.Nakazawa, N.Morita, K.Miyazawa, Y.Ishigaki:Febuxostat reduces calcium oxalate monohydrate
crystal-induced upregulation of MCP-1 in MDCK cells, 13th International Symposium on Urolithiasis, Makuhari,
2016.

7350I002

T.Arisawa, M.Ota, T.Tahara, J.Wu, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:A
polymorphisms of DNMT3A gene is clisely associated with the severity of gastric mucosal atrophy, APDW2016,
Kobe, 2016.

7350I003

J.Wu, T.Arisawa, T.Tahara, M.Ota, T.Nomura, R.Hayashi, T.Otsuka, T.Shimasaki, M.Nakamura, T.Shibata:The
association between genetic polymorphisms of DNMT3A(rs6733868 and rs13428812)and the susceptibility to thegastric cancer in japan, APDW2016, Kobe, 2016.

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7400

Research Support Center

Faculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Senior Assistant Professor(Additional Post)

MURAKAMI Manabu

Pathogenicity of flavivirus isolated from the field-collectedmosquitoes

Publications
Originals
7400B001(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

7400B002

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men., Journal of diabetes investigation, 7:3;343-351,
2016.

7400B003(T.Koyama), K.Yoshita, M.Sakurai, K.Miura, Y.Naruse, N.Okuda, A.Okayama, STAMLER Jeremiah, H.Ueshima,
H.Nakagawa:Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to thePrevention of Nutrient Deficiency: The INTERMAP Toyama Study, Journal of Nutritional Science andVitaminology, 62:2;101-107, 2016.

7400B004

M.Sakurai, J.Kobayashi, Y.Takeda, S.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi, H.Nakagawa:Sex Differences in
Associations Among Obesity, Metabolic Abnormalities, and Chronic Kidney Disease in Japanese Men and Women,
Journal of Epidemiology, 26:8;440-446, 2016.

7400B005

PT.Tai, M.Nishijo, TN.Nghi, H.Nakagawa. H.Van Luong, TH.Anh, H.Nishijo:Effects of Perinatal Dioxin Exposureon Development of Children during the First 3 Years of Life., The Journal of pediatrics, 175:159-166, 2016.

7400B006(XL.Sun), T.Kido, S.Honma, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, T.Nakano, E.Koh,
T.Takasuga, DD.Nhu, NN.Hung, K.Son Le:Influence of dioxin exposure upon levels of prostate-specific antigen
and steroid hormones in Vietnamese men, Environmental science and pollution research international, 23:8;78077813, 2016.

7400B007(D.Van Tung), T.Kido, S.Honma, HD.Manh, DD.Nhu, R.Okamoto, S.Maruzeni, M.Nishijo, H.Nakagawa, PT.Ngoc,
N.Van Toan, NN.Hung, NH.Minh, K.Son Le:Low birth weight of Vietnamese infants is related to their mother's
dioxin and glucocorticoid levels, Environmental science and pollution research international, 23:11;10922-10929,
2016.

7400B008

Y.Hamazaki, Y.Morikawa, S.Morimoto, H.Nakagawa:Difference in the impact of homebound status on functional
decline between independent older men and women: A 2 year follow-up study., Japan journal of nursing science,
13:2;265-272, 2016.

7400B009(K.Nakamura), M.Sakurai, Y.Morikawa, S.Nagasawa, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa:Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective
Study in Normoglycemic Japanese Men, Experimental and clinical endocrinology & diabetes : official journal,
German Society of Endocrinology [and] German Diabetes Association, 25:1;12-20, 2016.

7400B010(K.Nogawa), Y.Suwazono, M.Ishizaki, K.Aoshima, R.Okamoto, M.Nishijo, H.Nakagawa, T.Kido:Attenuation ofurinary cadmium in inhabitants of the environmentally exposed Jinzu River Basin determined by applying a mixed
linear model, Bulletin of environmental contamination and toxicology, 96:5;699-703, 2016.

-123-

7400B011

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, S.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa:Dietary carbohydrate intake, presence ofobesity and the incident risk of type 2 diabetes in Japanese men., Journal of diabetes investigation, 7:3;343-351,
2016.

7400B012(T.Koyama), K.Yoshita, M.Sakurai, K.Miura, Y.Naruse, N.Okuda, A.Okayama, STAMLER Jeremiah, H.Ueshima,
H.Nakagawa:Relationship of Consumption of Meals Including Grain, Fish and Meat, and Vegetable Dishes to thePrevention of Nutrient Deficiency: The INTERMAP Toyama Study, Journal of Nutritional Science andVitaminology, 62:2;101-107, 2016.

Reviews
7400C001

T.Shimasaki, S.Yamamoto, Y.Ishigaki, T.Takata, T.Arisawa, Y.Motoo, N.Tomosugi, T.Minamoto: Identification andfunctional analysis of an EMT-accelerating factor induced in pancreatic cancer cells by an anticancer agent, Suizo,
31:1;76-84, 2016.

Case Reports
7400D001

S.Miura, Y.Oikawa, N.Ueda, M.Murakami, N.Sakata: Case of viper (Glodius blomhoffii) bites treated withhospitalization in the Ishikawa Prefecture, Noto district, Clinical Parasitology, 27:1;75-77, 2016.

-124-

Affiliated Institution

9030

Northern Noto Institute for Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Professor(Additional Post)

ISHIZAKI Takeshi

Respiratory Medicine, Health Science, Postgraduate Education

Keywords of Research
Respiratory Medicine, Health Science, Postgraduate Education

Outline of Research
Effective development of best respiratory care for aged-people and education to respiratory care given in aged area.

Publications
Originals
9030B001

R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki,
N.F.Voelkel, H.Toga:Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic
obstructive pulmonary disease., Respiratory research, 17:1;139-151, 2016.

Case Reports
9030D001(M.Morikawa), Y.Fukuda, Y.Terasaki, H.Itoh, Y.Demura, M.Sasaki, Y.Imamura, C.Honjo, Y.Umeda, M.Anzai,
S.Ameshima, T.Ishizaki, T.Ishizuka:Osteogenesis Imperfecta Associated with Dendriform Pulmonary Ossification.,
American journal of respiratory and critical care medicine, 193:4;460-461, 2016.

-125-Himi Municipal Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

FUKUDA Akihiro

Cardiology

Professor

TOMIOKA Ryo

Neurology

Professor

MORIYAMA Manabu

Kidney transplantation，Urolithiasis

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Associate Professor

KIYOSAWA Jun

Cardiology

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

KONISHI Kazunori

adrenal diseases, diabetes, thyroid diseases

Associate Professor

IGUCHI Masaharu

Respiratory Medicine

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

IKEBUCHI Kimihiro

Orthopaedic Surgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

KOBATA Takashi

Cardiovascular Surgery

Senior Assistant Professor

AOKI Nobuyuki

Orthopaedic Surgery

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies

Assistant Professor

MIZUNO Takuro

Cardiology

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

SANGEN Ryusho

General Medicine

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

NAKAMURA Kisuke

Oncology Surgery

Assistant Professor

SAKAMOTO Daisuke Cardiovascular Surgery

Assistant Professor

KUSABA Eizo

Assistant Professor

SHIMADA Toshitsugu

neurosurgery

Publications
Originals
9100B001

T.Ikeda, Y.Yoshitomi, H.Saito, T.Shimasaki, H.Yamaya, T.Kobata, Y.Ishigaki, N.Tomosugi, Y.Yoshitake,
H.Yonekura:Regulation of soluble Flt-1(VEGFR-1) production by hnRNP D and protein arginine methylation,
Molecular and Cellular Biochemistry, 413:1-2;155-164, 2016.

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9100B002

R.Kato, S.Mizuno, M.Kadowaki, K.Shiozaki, M.Akai, K.Nakagawa, T.Oikawa, M.Iguchi, K.Osanai, T.Ishizaki,
N.F.Voelkel, H.Toga:Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic
obstructive pulmonary disease., Respiratory research, 17:1;139-151, 2016.

9100B003

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Catheter blockage factors in patients cared for in
their own home requiring long-term urinary catheterisation, International Journal of Urological Nursing, 1-8, 2016.

9100B004

D.Usuda, R.Sangen, Y.Hashimoto, E.Muranaka, Y.Iinuma, T.Kanda:Validation of a B-type natriuretic peptide as aprognostic marker in pneumonia patients: a prospective cohort study, BMJ open, 6:2;e010440, 2016.

Presentations at Conference
International Conference (Presentations)
9100I001

S.Maeda, T.Takiuti, M.Moriyama, Y.Kohno, H.Nakai, M.Fukuda:Development of a protocol for the prevention andmanagement of long-term indwelling urinary catheter blockage for visiting nurses, 17th international EAUN
meeting, Munich, 2016.

9100I002

T.Mizuno, A.Fukuda, Y.Izumi, J.Kiyosawa:Urinary Na and K excretion values in outpatients with hypertension
compared to patients with other diseases, The 26th Scientific Meeting of the International Society ofHypertension(ISH), Seoul, 2016.

9100I003

Y.Kasamaki, Y.Ozawa, H.Kawamura, T.Nakayama, D.Himitd, A.Fukuda, T.Mizuno, Y.Izum, M.Soma:Circadianvariation in pulse pressure: Comparison between, juvenile, middle-aged people and elderly people, The 26th
Scientific Meeting of the International Society of Hypertension(ISH), Seoul, 2016.

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