Kanazawa Medical University
Research Activities and Publications
VOL. 26 2014

Kanazawa Medical University

I
Cod

Department

N
Page

D

E

X

Code

Department

Page

Basic Medical Science
0100

Department of Anatomy ································· 10420

Department of General and Digestive Surgery · 63

0110

Department of Anatomy ································· 20430

Department of Orthopedics Surgery ··············· 66

0120

Department of Physiology ······························ 30440

Department of Neurosurgery ························· 69

0130

Department of Physiology ······························ 50450

Department of Plastic and Reconstructive

0140

Department of Biochemistry ··························· 70150

Department of Biochemistry ··························· 80460

Department of Pediatric Surgery ··················· 74

0160

Department of Pharmacology ························· 90470

Department of Ophthalmology ······················· 76

0170

Department of Pathology ······························100475

Department of Otorhinolaryngology················· 80

0180

Department of Pathology ······························110485

Department of Head and Neck Surgery ············ 82

0190

Department of Microbiology ··························130490

Department of Dermatology···························· 83

0200

Department of Immunology ···························140500

Department of Urology ································· 85

0210

Department of Medical Zoology ·······················150510

Department of Obstetrics and Gynecology ······· 56

0220

Department of Pathology and Laboratory

0520

Department of Anesthesiology and Perioperative

Surgery ······················································ 71

Medicine ····················································· 88

Medicine ·····················································170230

Department of Social and Environmental

0540

Department of Physical and Rehabilitation
Medicine ····················································· 89

Medicine ·····················································20
Department of Epidemiology and Public Health0550

Department of Emergency Medicine ················ 91···································································220570

Department of Community Medicine ··············· 92

0250

Department of Legal Medicine ·······················260575

Department of Gastroenterological Endoscopy ·· 93

0260

Department of Medical Education ··················270580

Department of Oral and Maxillofacial Surgery ·· 95

0240

Clinical Medicine

University Hospital

0300

Department of Cardiology ·····························280635

Hepatology ･････････ ····································· 96

0310

Department of Respiratory Medicine

0675

Health Evaluation Center ····························· 98

0320

Department of Gastroenterology ····················320330

Department of Nephrology ····························360340

Department of Diabetology and Endocrinology ··397100

Department of Life Science ··························· 101

0350

Department of Hematology and Immunology ···427200

Department of Advanced Medicine ················ 105

0360

Department of Neurology ······························447310

Division of Innovative Research ···················· 109

0363

Department of Medical Oncology ····················467320

Division of Vision Research for Environmental

0366

Department of Infectious Diseases ·················480368

Department of General Internal Medicine ·······49

7330

Division of Dermatomycology ························ 114

0370

Department of Geriatric Medicine····················51

7340

Division of Anticipatory Molecular Food Science

0380

Department of Pediatrics ······························530390

Department of Neuropsychiatry ·····················550400

Department of Radiology ······························570410

Department of Cardiovascular Surgery ···········590415

Department of Thoracic Surgery ····················60·············30

Medical Research InstituteHealth ······················································· 111

and Technology ··········································· 116
7400

Research Support Center ····························· 119

School of
8010

Fundamental Nursing

Nursing······························ 122CodDepartment

Page

8040

Adult Nursing ··········································· 123

8050

Gerontological Nursing ······························· 124

8060

Pediatric Nursing ······································ 125

8070

Maternity Nursing・Midwifery ····················· 126

8080

Community Health Nursing ························ 127

8085

Psychiatric and Mental Health Nursing ········· 129

8090

Home Care Nursing ··································· 131

8095

Comprehensive Nursing ······························ 132

8100

Medical Science ········································· 133

Department of General Education
8610

Natural Science ········································· 136

8620

Human Science ·········································· 138

Affiliated Institution
9030

Northern Noto Institute of Community
Medicine ··················································· 140

9050

FDD-MB Center ········································ 141

Himi Municipal
9100

Hospital

Himi Municipal Hospital ······························ 142

CodeDepartment

Page

Basic Medical Science

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001(T.Inoue), RHashimoto, A.Matsumoto, E.Jahan, AM.Rafiq, J.Udagawa, T.Hatta, H.Otani: In vivo analysis of ArgGly-Asp Sequence/Integrin α5β1-mediated signai involvement in embryonic enchondral ossification by exo utero
development system., J. Bone Miner. Res., 29:1554-63, 2014.

Reviews
0100C001

T.Arikawa, E.Simamura, H.Shimada, T.Nakamura, T.Hatta, H.Shoji: Significance of sugar chain recognition by
galectins and its involvement in disease-associated glycosylation, Congenit. Anom. (Kyoto), 54:77-81, 2014.

－ 1 －

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

HONMA Satoru

gross anatomy

Professor

SHINOHARA
Harumichi

gross anatomy, embryology, lymphatic vessels, microscopy

Senior Assistant Professor

SONOMURA Takahiro

Neuroanatomy, immunohistochemistry, electron microscopy, 3D
reconstruction

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy, central nervous system

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry, pituitary, cell proliferation, electron
microscopy

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA, Neuroanatomy,
FIB/SEM, BMI, gustatory

Outline of Research
Theme of researches
1)Human gross anatomy
2)Neural network of the basal ganglia
3）Circuit of gustatory in the central nervous system
4）Anatomical study of brain white matter by using fiber dissection technique5）Immuno-histochemical study of pituitary gland

－ 2 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Senior Assistant Professor

TAJIMA Nobuyoshi

molecular physiology

Senior Assistant Professor

MATSUDA Naoto

Neuroscience

Assistant Professor

UCHIUMI Osamu

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001(H.Yoshimura), M.Hasumoto, T.Sugai, N.Segami, N.Kato: Enhancement of oscillatory activity in the endopiriform
nucleus of rats raised under abnormal oral conditions., Neurosci. Lett., 561:162-165, 2014.

0120B002

R.Yamamoto, N.Hatano, T.Sugai, N.Kato: Serotonin induces depolarization in lateral amygdala neurons byactivation of TRPC-like current and inhibition of GIRK current depending on 5-HT2C receptor,
Neuropharmacology., 82:49-58, 2014.

－ 3 －Presentations at Conference
International Conference (Synposium)
0120H001

N.Tajima, Y. Itokazu, ER. Korpi, P.Somerharju, R.Käkelä: Activity of BK channel is modulated by Membranecholesterol content and association with Na+/K+-ATPase., The 45th NIPS International Symposium Co-sponsoredby The Journal of Physiology, (Okazaki, '14.11).

International Conference (Presentations)
0120I001

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocyte in a rat spinal cord hemisection model, CSRS AP5 Viet Nam 2014, (Ho Chi Minh, '14.04).

0120I002

K.Tanaka, Y.Li, L.Li Wang, N.Kato, M.Matsui, T.Takegami: Memory disturbance of the mice treaｔed withintraventricular administration of CSF from NMDAR-encephalitis patients, American Academy of Neurology 2014
Aunual Meeting, (Philadelphia, '14.05).

0120I003

L.Wang, R.Yamamoto, N.Kato: Neuronal effects of BK channel opener applied to a mouse Alzheimer diseasemodel., Neuroscience 2014 -Society for Neuroscience-, (Washington,DC, '14.11).

0120I004

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocytes in a rat spinal cord hemisection model, Neuroscience 2014, (Washington,DC, '14.11).

－ 4 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

TANIDA Mamoru

Circulatory Physiology

Assistant Professor

KUDA Yuichi

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

M.Tanida, K.Imanishi, H.Akashi, Y.Kurata, O.Chonan, E. Naito, S.Kunihiro, M.Kawai, A.Kato-Kataoka,
T.Shibamoto: Injection of Lactobacillus casei strain Shirota affects autonomic nerve activities in a tissue-specificmanner, and regulates glucose and lipid metabolism in rats., J Diabetes Investig, 5:153-161, 2014.

0130B002

L.Sun, M.Tanida, M.Wang, Y.Kuda, Y.Kurata, T.Shibamoto: Effects of anesthetics on the renal sympathetic
response to anaphylactic hypotension in rats., PLoS ONE, 9:e113945;1-15, 2014.

0130B003

M.Wang, T.Shibamoto, Y.Kuda, L.Sun, M.Tanida, Y.Kurata.: Angiotensin II and vasopressin are involved in the
defense system against anaphylactic hypotension in anesthetized rats., Eur. J. Pharmacol., 731:38-43, 2014.

0130B004

M.Wang, T.Shibamoto, M.Tanida, Y.Kuda, Y.Kurata: Mouse anaphylactic shock is caused by reduced cardiac
output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine., Life Sci.,
116:98-105, 2014.

0130B005(N.Yamamoto), M.Tanida, R.Kasahara, K.Sobue, K.Suzuki: Leptin inhibits amyloid β-protein fibrillogenesis bydecreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway., J. Neurochem.,
131:323-332, 2014.

－ 5 －0130B006(N.Yamamoto,), M.Tanida, Y.Ono, R.Kasahara, Y.Fujii, K.Ohora, K.Suzuki, K.Sobue: Leptin inhibits amyloid βprotein degradation through decrease of neprilysin expression in primary cultured astrocytes., Biochem. Biophys.
Res. Commun., 445:214-217, 2014.

0130B007(S.Sakata), Y.Kurata, P.Li, T.Notsu, K.Morikawa, J.Miake, K.Higaki, Y.Yamamoto, A.Yoshida, Y.Shirayoshi,
K.Yamamoto, M.Horie, H.Ninomiya, S.Kanzaki, I.Hisatome: Instability of KCNE1-D85N that causes long QT
syndrome: stabilization by verapamil., Pacing Clin. Electrophysiol., 37:853-863, 2014.

0130B008(H.Matsugami), Y.Harada, Y.Kurata, Y.Yamamoto, Y.Otsuki, H.Yaura, Y.Inoue, K.Morioka, A.Yoshida,
Y.Shirayoshi, Y.Suyama, B.Nakayama, H.Iwaguro, K.Yamamoto, I.Hisatome: VEGF secretion by adipose tissuederived regenerative cells is impaired under hyperglycemic conditions via glucose transporter activation and ROS
increase, Biomed. Res., 35:397-405, 2014.

0130B009

Y.Kuda, Y.Kurata, M.Wang, M.Tanida, T.Shibamoto: Major contribution of vasospasm-induced coronary blood flow
reduction to anaphylactic ventricular dysfunction assessed in isolated blood-perfused rat heart, Cardiol J., 21:1117, 2014.

0130B010

M.Tanida, K.Imanishi, M.Komatsu, J.Satomi, N.Yamamoto, M.Wang, Y.Kurata, T.Shibamoto: Soy isoflavone affects
the autonomic nervous system in a tissue-specific manner in anesthetized rats, Exp. Biol. Med. (Maywood),
239:477–483, 2014.

Reviews
0130C001(K.Nagai), A.Niijima, Y.Horii, J.Shen, M.Tanida: Olfactory stimulatory with grapefruit and lavender oils change
autonomic nerve activity and physiological function., Auton. Neurosci., 185:29-35, 2014.

Presentations at Conference
International Conference (Presentations)
0130I001

M.Kitadate, H.Tonami, T.Shibamoto: Hemodynamics of portal venules during anaphylactic shock : Experimental
study by means of hepatic venography, Asia-Pacific Congress of Cardiovascular and Interventional Radiology,(Shingapore, '14.05).

0130I002

T.Shibamoto, M.Wang, Y.Kuda, M.Tanida, Y.Kurata: Angiotensin II and vasopressin serve as the defense systemagainst rat anaphylactic shock, 37th Annual Conference on Shock, (Charlotte, '14.06)，SHOCK2014, 41 (Suppl 2);
49-50, 2014.

－ 6 －

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SAKASAI Ryo

DNA damage response induced by anti-cancer drugs

Assistant Professor

SUNATANI Yumi

Function of DNA double-strand break proteins

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, K.Iwabuchi, N.Tomosugi: RNA-binding protein RBM8A (Y14)and MAGOH localize to centrosome in human A549 cells., Histochem. Cell Biol., 141:101-109, 2014.

0140B002(JS.Yoo), K.Takahasi, CS.Ng, R.Ouda, K.Onomoto, M.Yoneyama, JC.Lai, S.Lattmann, Y.nagamine, T.Matsui,
K.Iwabuchi, H.Kato, T.Fujita: DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stressgranule formation., PLoS Pathog., 10:e1004012;1-18, 2014.

0140B003(B.Guerra), K.Iwabuchi, OG.Issinger: Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA
double-strand break induced by radiomimetic drugs., Cancer Lett., 345:115-123, 2014.

Presentations at Conference
International Conference (Presentations)
0140I001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Role of RNA binding
protein in cell cycle progression and centrosome maturation in human tumor cells., 19th World Congress on
Advances in Oncology & 17th International Symposium of Molecular Medicine, (Greece, '14.10).

0140I002

R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi: Ubiquitin-dependent activation of DNA-PKcs in
response to DNA replication-mediated DNA double strand breaks, The 9th 3R Symposium Together with National
Institute of Genetics 2014 International Symposium, (Gotenba, '14.11)，Abstracts, 105, 2014.

－ 7 －

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate Professor

YOSHITAKE Yoshino

MicroRNA involved in angiogenesis, Functions of FGF-2 binding
proteinSenior Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Faculty

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

－ 8 －

0160

Department of Pharmacology

Faculty
Title

Name

Professor

Field of Specialization

Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascular
ISHIBASHI Takaharu
systemElectrophysiology and behavioural pharmacology in central and
MASUOKA Takayoshi
periphenal nervous system
NISHIO Matomo

Professor(Additional Post)
Senior Assistant Professor
Senior Assistant Professor

YOSHIDA Junko

Assistant Professor

IMAIZUMI Noriko

Researcher

KUDO Makiko

Pharmacology in cardiovascular system, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy
Electrophysiology and behavioural pharmacology in central andperiphenal nervous system

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitricoxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation,
cell biology, hippocampal synapses, muscarinic acetylcholine receptorrvous system, peripheral sensory neuron, autonomic
neuron, central ne, metabotropic glutamate receptor, receptorology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system
６ Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation

Publications
Originals
0160B001(J.Uwada), H.Yoshiki, T.Masuoka, M.Nishio, I.Muramatsu: Intracellular localization of the M1 muscarinic
acetylcholine receptor through clathrin-dependent constitutive internalization is mediated by a C-terminal
tryptophan based motif., J. Cell. Sci., 127:3131-3140, 2014.

0160B002(H.Yoshiki), J.Uwada, AS.Anisuzzaman, H.Umada, R.Hayashi, R.Kainoh, Masuoka T, Nishi M, I.Muramatsu:
Pharmacologically distinct phenotypes of α1B-adrenoceptors: variation in binding and functional affinities forantagonists., Br. J. Pharmacol., 171:4890-4901, 2014.

－ 9 －

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Assistant Professor

YOSHIZAKI Hisayoshi Molecular and Cellular Biology，Fluorescent Imaging

Assistant Professor

TAKEDA Haruna

Mouse model for carcinogenesis、Two-photon microscopy imaging

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration

Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer
development and invasion/metastasis, and epithelial regeneration.. We also develop the system to manipulate cell signaling
to understand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating rolesof DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.

Publications
Originals
0170B001(R.Mizuno), Y.Kamioka, K.Kabashima, M.Imajo, K.Sumiyama, E.Nakasho, T.Ito, Y.Hamazaki, Y.Okuchi, Y.Sakai,
E.Kiyokawa, M.Matsuda: In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to
inflamed intestines, J. Exp. Med., 211:1123-1136, 2014.

0170B002

H.Yoshizaki, S.Okuda: Elucidation of the evolutionary expansion of phosphorylation signaling networks using
comparative phosphomotif analysis., BMC Genomics, 15:546;1-17, 2014.

Reviews
0170C001

E.Kiyokawa, H.Minato: Activated K-RAS and its effect on morphological appearance., J. Biochem., 156:137-145,
2014.

Presentations at Conference
International Conference (Presentations)
0170I001

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosi: Its relationship to posterior capsule
opacity, International Conference on the Lens, (Hawaii, '14.01).

0170I002

T.Shibata, S.Shibata, E.Kiyokawa, H.Sasaki, E.Kubo: Tropomyosi: Inhibition of progression of sugar cataract ingalactose-fed rats and induction of anti-oxidant protein, Peroxiredoxin 6, International Conference on the Lens,(Hawaii, '14.01).

0170I003

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosin regulation of stress fiber formationand EMT in lens epithelial cells, Association for Research in Vision and Ophthalmology, (Orlando, '14.05).

0170I004

H.Takeda, H.Yoshizaki, E.Kiyokawa: Live imaging of the mouse stomach with two-photon excitation microscopy,
The 37th Naito Coference Bioimaging-a paradigm shift for the life sciences, (Niseco, '14.07).

－ 10 －

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Neuropathology

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, M.Taniguchi, H.Tonami, Y.Ueda,
T.Sakuma: Relationships between EGFR mutation status of lung cancer and preoperative factors-are they
predictive?, Asian Pac. J. Cancer Prev., 15:657-662, 2014.

0180B002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, Y.Kuginuki, M.Taniguchi,
H.Tonami, Y.Ueda, T.Sakuma: Diagnostic performance of diffusion weighted imaging of malignant and benign
pulmonary nodules and masses: comparison with positron emission tomography, Asian Pac. J. Cancer Prev.,
15:4629-4635, 2014.

0180B003

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, H.Tonami, Y.Ueda,
T.Sakuma: Recurrence and metastasis of lung cancer demonstrate decreased diffusion on diffusion-weighted
magnetic resonance imaging, Asian Pac. J. Cancer Prev., 15:6843-6848, 2014.

Case Reports
0180D001(T.Yoneda), M.Uo, H.Koba, T.Sakai, Y.Ueda, K.Kasahara: Two cases of invasive thymoma with postoperative
recurrence and expansion into the bronchial lumen, Proceedings of the Japanese Lung Cancer Society Lungcancer., 54:191-198, 2014 (in Japanese) .

－ 11 －

0180D002(T.Yoneda), H/Koba, T.Saka, MYamazakii, Y.Ueda, K.Kasahara: A case of malignant pleural mesothelioma thatwas difficult to differentiate from other posterior mediastinal tumors, Proceedings of the Japanese Lung Cancer
Society Lung cancer., 54:218-225, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0180I001

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma: DiffusionWeighted manetic resonance lmaging(DWI)signal intensity and distribution represents the amount of cancer,
American Thoracic Society International Canference 2014, (SanDiego, '14.05).

0180I002

M.Wakasa, K.Takeda, A.Motoyama, R.Ishida, H.Akao, Y.Kawai, M.Kitayama, Y.Ueda, K.Kajinami: The longestlived homozygous familial hypercholesterolemia as geneticaly-determined mild phenotype:an autopsy case of fhtonami2, European Atherosclerosis Society 82nd EAS Congress, (Madrid, '14.05).

0180I003

M.Tanaka, Y.Ueda, M.Shimasaki, M.Ueno, Y.Machida, N.Motono, K.Usuda, M.Sagawa, T.Sakuma: Increased
expression of receptor for advanced glycation end products in COPD, ERS Annual Congress 2014, (Munich,'14.09).

－ 12 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology, Neuroimmunology

Professor

MURAKI Yasushi

Virology

Associate Professor

HIMEDA Toshiki

Neurovirology

Assistant Professor

OKUWA Takako

Virology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

M.Zhou, K.Osanai, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, Y.Muraki, H.Toga: Adenovector-mediatedgene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats,
Crit. Care Med., 42:e716-e724, 2014.

0190B002(A.Shimizu), T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara: Role(s) of leader protein of saffold virus., Clin. Exp.
Neuroimmunol., 5:362-366, 2014.

Others
0190F001

Y.Ohara: Cell-to-cell- transmission in the pathogenesis of human T-lymphotropic virus type 1-associatedmyelopathy/tropical spastic paraparesis, Clin. Exp. Neuroimmunol., 5:117-119, 2014.

0190F002

Y.Ohara: Fingolimod effects as a neuroprotectant as well as an immunosuppressant., Clin. Exp. Neuroimmunol.,
5:281-282, 2014.

－ 13 －

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology

Professor(Additional Post)

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Assistant Professor

TAKEDA Kazuya

Immunology, Neuropathology

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology

Assistant Professor

WADA Toshiki

Immunology, Functional biochemistry, Structural biochemistry

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

Publications
Originals
0200B001(C.J.Treda), T.Fukuhara, T.Suzuki, A.Nakamura, J.Zaini, T.Kikuchi, M.Ebina, T.Nukiwa: Secretory leukocyte
protease inhibitor modulates urethane-induced lung carcinogenesis, Carcinogenesis., 35: 896-904, 2014.

0200B002(Y.Kanari), A.Sugahara-Tobinai, H.Takahashi, M.Inui, A.Nakamura, S.Hirose, T.Takai: Dichotomy in FcγRIIB
deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development ofautoantibodies and glomerulonephritis, BMC Immunol., 15:47;1-13, 2014.

－ 14 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.2.Epidemiological research of tickborn diseases in the Noto Peninsula,Ishikawa Prefect.

Publications
Originals
0210B001(A.Takano), H.Fujita, T.Kadosaka, M.Takahashi, T.Yamauchi, F.Ishiguro, N.Takada, Y.Yano, Y.Oikawa, T.Honda,
M.Gokuden, T.Tsunoda, M.Tsurumi, S.Ando, M.Andoh, K.Sato, H.Kawabata: Construction of a DNA database forticks collected in Japan: application of molecular identification based on the mitochondrial 16S rDNA gene., Med.
Entomol. Zool., 65:13-21, 2014.

0210B002(K.Nakamato), M.Tokoro, T.Nakamoto, A.Saito-Ito, Y.Oikawa, N.Takada, T.Mastumura, S.Arayama,
M.Kamaruddin: Widespread distribution of trypanosoma (herpetosoma) grosi in Japanese field mice(apodemus
speciosus), Jpn. J. Vet. Parasitol., 13:67-73, 2014.

0210B003(N.Yamazaki), A.Kobayashi, H.Yokogawa, Y.Ishibashi, Y.Oikawa, M.Tokoro, K.Sugiyama: In vivo imaging of radial
keratoneuritis in patients with acanthamoeba keratitis by anterior-segment optical coherence tomography.,
Ophthalmology, 121:2153-2158, 2014.

Case Reports
0210D001

K.Ikemura, T.Fujii, S.Abe, T.Mochizuki, Y.Oikawa: The first case of Amblyomma testudinarium tick bite in
Ishikawa prefecture, Japan, J. Kanazawa. Med. Univ., 39:42-44, 2014 (in Japanese) .

Short Communications
0210E001(T.Masuzawa), S.Masuda, T.Fukui, Y.Okamoto, J.Bataa, Y.Oikawa, F.Ishiguro, N.Takada: PCR detection of
Anaplasma phagocytophilum and Borrelia burgdorferi in Ixodes persulcatus ticks in Mogolia., Jpn. J. Infect. Dis.,
67:47-49, 2014.

－ 15 －

Presentations at Conference
International Conference (Synposium)
0210H001

Y.Oikawa: Mites inducing an atopic dermatitis-like skin lesion in NC mice, XIV International Congress of
Acarology, (Kyoto, '14.07)，XIV International Congress of Acarology Abstract Book, 34, 2014.

－ 16 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Assistant Professor

FUKUSHIMA Mana

surgical pathology

Assistant Professor

KOBAYASHI Erikosurgical pathology, molecular pathology

Assistant Professor

NAKADA Satoko

surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Books
0220A003

Y.Masaki, N.Kurose, H.Tonami, H.Umehara: Other organs(central nervous system,prostate), IgG4-RelatedDisease(H.Umehara, K.Okazaki, JH.Stone, S.Kawa, M.Kawano), 113-117, Springer Japan, Tokyo, 2014.

Publications
Originals
0220B001

H.Minato, N.Kurose, M.Fukushima, T.Nojima, K.Usuda, M.Sagawa, T.Sakuma, A.Ooi, I.Matsumoto, M.Oda,
Y.Arano, J.Shimizu: Comparative immunohistochemical analysis of IMP3, GLUT1, EMA, CD146, and desmin for
distinguishing malignant mesothelioma from reactive mesothelial cells, Am. J. Clin. Pathol., 141:85-93, 2014.

0220B002(K.Hayashi), H.Tsuchiya, N.Yamamoto, T.Shirai, H.Nishida, A.Takeuchi, H.Kimura, S.Miwa, H.Inatani,
H.Okamoto, S.Yamada, H.Ikeda, S.Sawada-Kitamura, T.Nojima, A.Ooi, T.Otsuka: Diagnosis and treatment of lowgrade osteosarcoma: experience with nine cases, Int. J. Clin. Oncol., 19:731-738, 2014.

0220B003

K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto: Inversion of the acetabular labrum triggers rapidly destructive
osteoarthritis of the hip: Representative case report and proposed etiology, J. Arthroplasty., 29:2468-2472, 2014.

－ 17 －

0220B004

Y.Sasagawa, T.Akai, S.Nakada, H.Minato, O.Tachibana, T.Nojima, H.Iizuka: Narrow band imaging-guided
endoscopic biopsy for intraventricular and paraventricular brain tumors:clinical experience with 14 cases, Acta
Neurochir (Wien), 156:681-687, 2014.

Reviews
0220C001

E.Kiyokawa, H.Minato: Activated K-RAS and its effect on morphological appearance., J. Biochem., 156:137-145,
2014.

0220C003

T.Nojima: The pathologic diagnosis of bone and soft tissue tumors:update, Rinsho Byori, 62:578-585, 2014 (inJapanese) .

Case Reports
0220D001(S.Suzuki), F.Tanioka, H.Minato, A.Ayhan, M.Kasami, H. Sugimura: Breakages at YWHAE, FAM22A, andFAM22B loci in uterine angiosarcoma: A case report with immunohistochemical and genetic analysis., Pathol. Res.
Pract., 210:130-134, 2014.

0220D002

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

0220D003

K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto: Imaging and histopathological evaluation of a cystlike formationin subchondral insufficiency fracture of the femoral head: a case report and literature review., Int J Surg Case Rep.,
5:324-329, 2014.

0220D004(S.Suzuki), N.Kurabe, H.Minato, A.Ohkubo, I.Ohnishi, F.Tanioka, H.Sugimura: A rare Japanese case with a NUT
midline carcinoma in the nasal cavity: A case report with immunohistochemical and genetic analyses, Pathol. Res.
Pract., 210:383-388, 2014.

0220D005(H.Kimura), N.Yamamoto, H.Nishida, K.Hayashi, A.Takeuchi, T.Nojima, H.Ikeda, S.Sawada-Kitamura, H.Tsuchiya:
Synovial sarcoma in knee joint, mimicking low-grade sarcoma confirmed by molecular detection of SYT gene split.,
Anticancer Res., 34:3105-3112, 2014.

0220D007

K.Kato, N.Segami, H.Fukuda, H.Minato: Rheumatoid nodule in the lower lip of a patient with rheumatoid arthritis:
a novel case report and review of literature., J. Oral Maxillofac. Surg., 72:1532.e1-1352.e5, 2014.

0220D008(H.Suzuki), K.Yamashiro, H. Takeda, H.Hiraga, T.Soma,, T.Osanai, K.Isu K, T.Nojima: Adult rhabdomyoma of theextremity, Int. J. Surg. Pathol., 22:634-639, 2014.

0220D009(J.Shimizu), T.Kamesui, M.Moriya, S.Murata, I.Nakanishi, M.Sasaki, H.Minato: Four cases of invasive anterior
mediastinal tumors definitively diagnosed by the chamberlain procedure., Ann. Thorac. Cardiovasc. Surg., 20:434440, 2014.

0220D010(H.Yamamoto), J.Soh, K.Ichimura, Y.Konishi, S.Toyooka, T.Nojima, S.Miyoshi: Adult mesenchymal hamartoma of
the chest wall: Report of a case, Ann. Thorac. Cardiovasc. Surg., 20:663-665, 2014.

0220D011

M.Doai, H.Tonami, N.Tsuchiya, T.Akai, N.Kurose, K.Hirata: 1H-MR spectroscopy in a case of isolated
intracranial rosai-dorfman disease, J Neurol Sci Turk, 31:790-795, 2014.

0220D012

T.Onishi, N.Ueda, T.Kosaka, S.Nakata, H.Minato: A case of intraductal papillary neoplasm of the bile duct (IPNB)
that underwent curative resection after follow-up of 1 year 4 months without treatment, Tondo, 28:81-88, 2014 (inJapanese) .

0220D013

I.Chikazawa, D.Nakai, M.Morita, H.Tachibana, T.Tanaka, K.Miyazawa, M.Kishibe, Y.Kamimura, E.Kinoshita,
N.Kurose: Skin and lung metastasis from renal cell carcinoma 23 years after radical nephrectomy-a case report-,
Jpn. J. Cancer Clin., 60:537-542, 2014 (in Japanese) .

－ 18 －

Others
0220F001(M. Mizawa), T.Makino, O.Norisugi, H.Hara, K.Shimizu, K.Nomura, H.Kanegane, T.Nojima, T.Shimizu: Primary
cutaneous Ewing sarcoma following metastasis to the bone and lymph nodes, Br. J. Dermatol., 171:660-662, 2014.

Presentations at Conference
International Conference (Presentations)
0220I001

M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, S.Miura, Y.Nakano, T.Kosaka, N.Kurose, H.Minato: Feasibility studyof axillary reverse mapping for patients with clinically node-negative breast cancer, 18th SIS World Congress on
Breast Healthcare, (Orlando, '14.10).

－ 19 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseasesProfessor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stressSenior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stressSenior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, T.Kido, T.Kido, Y.Naruse,
Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-year risk fortype 2 diabetes mellitus in middle-aged Japanese men, Eur. J. Nutr., 53:251-258, 2014.

0230B002

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

0230B003(E.A.Kim), M.Nakata: Work-related musculoskeletal disorders in Korea and Japan: a comparative description, Ann
Occup Environ Med., 26:17;1-7, 2014.

0230B004(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

0230B005

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

0230B006

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

0230B007

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

－ 20 －

0230B008

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

0230B009

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

Reviews
0230C001

Y.Noborisaka, M.Yamazaki, Y.Yamada: Life, work and chronic kidney disease (CKD), 社医研, 31:1-11, 2014 (inJapanese) .

Others0230F001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,, Y.
Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-yearrisk for type 2 diabetes mellitus in middle-aged Japanese men., Eur. J. Nutr., 53:1137-1138, 2014.

－ 21 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate Professor

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

NAKANISHI Yumiko

Preventive medicine

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Associate
Professor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001

X.Zhao, A.Nogawa, T.Matsunaga, T.Takegami, H.Nakagawa, Y.Ishigaki: Proteasome inhibitors and knockdown of
SMG1 cause accumulation of Upf1 and Upf2 in human cells., Int. J. Oncol., 44:222-228, 2014.

0240B002

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, T.Kido, T.Kido, Y.Naruse,
Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-year risk fortype 2 diabetes mellitus in middle-aged Japanese men, Eur. J. Nutr., 53:251-258, 2014.

0240B003

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

0240B004(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

－ 22 －

0240B005

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

0240B006

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

0240B007

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

0240B008

M.Nishijo, Y.Suwazono, W.Ruangyuttikarn, K.Nambunmee, W.Swaddiwudhipong, K.Nogawa, H.Nakagawa: Risk
assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid
approach of inhabitants living in polluted and non-polluted areas in Thailand, BMC Public Health, 14:702;1-9,
2014.

0240B009

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

0240B010

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

0240B011(Emerging Risk Factors Collaboration), H.Nakagawa, M.Sakurai, K.Nakamura, Y.Morikawa, et al.: Glycatedhemoglobin measurement and prediction of cardiovascular disease., JAMA, 311:1225-1233, 2014.

0240B012(K.Asayama), M.Satoh, Y.Murakami, T.Ohkubo, SY.Nagasawa, I.Tsuji, T.Nakayama, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura, Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCHJAPAN) Research Group, H.Nakagawa, et al.: Cardiovascular risk with and without antihypertensive drug
treatment in the Japanese general population: participant-level meta-analysis., Hypertension, 63:1189-1197, 2014.

0240B013

H.Shiga, J.Yamamoto, M.Kitamura, H.Nakagawa, T.Matsubasa, A.Seo, T.Miwa: Combinations of two odorants ofsmell identification test for screening of olfactory impairment., Auris Nasus Larynx, 41:523-527, 2014.

0240B014(T.Hisamatsu), K.Miura, T.Ohkubo, T.Yamamoto, A.Fujiyoshi, N.Miyagawa, A.Kadota, N. Takashima, N.Okuda,
K. Yoshita, Y.Kita, Y.Murakami, Y.Nakamura, T.Okamura, M.Horie, A.Okayama, H.Ueshima, NIPPON DATA80
Research Group, H.Nakagawa, et al.: High long-chain n-3 fatty acid intake attenuates the effect of high restingheart rate on cardiovascular mortality risk: a 24-year follow-up of Japanese general population., J. Cardiol.,
64:218-224, 2014.

0240B015(N.Okuda), J.Stamler, IJ. Brown, H.Ueshima, K.Miura, A.Okayama, S.Saitoh, H.Nakagawa, K.Sakata, K.Yoshita,
L.Zhao, P.Elliott, the INTERMAP Research Group: Individual efforts to reduce salt intake in China, Japan, UK,
USA: what did people achieve? The INTERMAP population study., J. Hypertens., 32:2385-2392, 2014.

0240B016(TV.Pereira), L.Kimura, Y.Suwazono, H.Nakagawa, M.Daimon, T.Oizumi, T,Kayama, T.Kato, L.Li, S.Chen, D.Gu,
W.Renner, W.März, Y.Yamada, PG.Bagos, RC.Mingroni-Netto: Multivariate meta-analysis of the association of Gprotein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes., Mol. Biol. Rep., 41:3113-3125, 2014.

0240B017

M.Nishijo, PT.Tai, TNA.Nguyen, TN.Nghi, H.Nakagawa, HV,Luong, AH.Tran, Y.Morikawa, HD.Manh, T.Kido,
MN.Nui, NM.Hai, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-yearold children in Vietnam., Mol. Psychiatry., 19:1220-1226, 2014.

0240B018(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women., Eur. J. Endocrinol., 170:131-139, 2014.

0240B019(HD.Manh), T.Kido, R.Okamoto, S.Xianliang, Le T.Anh, S.Supratman, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, T.Nakano, T.Takasuga, DD.Nhu, NN. Hung, LK.Son: Serum dioxin levels in vietnamese men more than
40 years after herbicide spraying., Environ. Sci. Technol., 48:3496-3503, 2014.

－ 23 －

0240B020(H.Suzuki), T.Kido, R.Okamoto, DD.Nhu, M.Nishijo, H.Nakagawa, K.Tawara, H.Horikawa, Y.Sato, PT.Dung,
LH.Thom, NN.Hung: The relationship between dioxin congeners in the breast milk of Vietnamese women and sister
chromatid exchange., Int. J. Mol. Sci., 15:7485-7499, 2014.

0240B021(XL.Sun), T.Kido, R.Okamoto, HD.Manh, S.Maruzeni, M.Nishijo, H.Nakagawa, S.Honma, T.Nakano, T.Takasuga,
DD.Nhu, NN.Hung, LK.Son: Relationship between dioxin and steroid hormones in sera of Vietnamese men.,
Biomarkers., 19:236-240, 2014.

0240B022(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa: Impact of urinary
cadmium on mortality in the Japanese general population in cadmium non-polluted areas., Int. J. Hyg. Environ.
Health., 217:807-812, 2014.

0240B023(K.Ishikura), H.Misu, M.Kumazaki, H.Takayama, N.Matsuzawa-Nagata, N.Tajima, K.Chikamoto, F.Lan, H.Ando,
T.Ota, M.Sakurai, Y.Takeshita, K. Kato, A. Fujimura, KI.Miyamoto, Y.Saito, S.Kameo, Y.Okamoto, Y.Takuwa,
K.Takahashi, H.Kidoya, N.Takakura, S.Kaneko, T.Takamura: Selenoprotein P as a diabetes-associated hepatokine
that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells., Diabetologia, 57:1968-1976,
2014.

0240B024(T.Inohara), S.Kohsaka, T.Okamura, M.Watanabe, Y.Nakamura, A.Higashiyama, A.Kadota, N.Okuda, Y.Murakami,
T.Ohkubo, K.Miura, A.Okayama, H.Ueshima, the NIPPON DATA 80/90 Research Group, H.Nakagawa, et al.:Cumulative impact of axial, structural, and repolarization ECG findings on long-term cardiovascular mortality
among healthy individuals in Japan: National Integrated Project for prospective observation of Non-Communicabledisease and its trends in the aged, 1980 and 1990., Eur J Prev Cardiol., 21:1501-1508, 2014.

0240B025(N.Miyagawa), K.Miura, N.Okuda, T.Kadowaki, N.Takashima, SY.Nagasawa, Y.Nakamura, Y.Matsumura,
A.Hozawa, A.Fujiyoshi, T.Hisamatsu, K.Yoshita, A.Sekikawa, T.Ohkubo, RD.Abbott, T.Okamura, A.Okayama,
H.Ueshima, the NIPPON DATA80 Research Group, H.Nakagawa, et al.: Long-chain n-3 polyunsaturated fatty
acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80,
Atherosclerosis, 232:384-389, 2014.

0240B026(A.Okayama), N.Okuda, K.Nakamura, K.Miura, S.Yasumura, K.Sakata, H.Hidaka, T.Okamura, K.Nishimura:
Method for evaluating health promotion programs using propensity score, Health Evaluation and Promotion,
41:418-427, 2014 (in Japanese) .

0240B027(T.Koyama), K.Yoshita, Y.Arai, K.Nakamura, M.Sakurai, M.Nishijo, SY.Nagasawa, Y.Morikawa, M.Tabata,
H.Nakagawa: Relationship between daily intake frequency of meals including a staple food,a main dish and a sidedish and nutrient intake in independent elderly individuals, Journal of Japanese Society of Nutrition and Food
Science., 67:299-305, 2014 (in Japanese) .

Reviews
0240C001

K.Nakamura: Impact of cardiovascular risk factors on medical expenditure: evidence from epidemiological studies
analysing data on health checkups and medical insurance, J. Epidemiol., 24:437-443, 2014.

0240C002

K.Nakamura, T.Okamura, K.Miura, A.Okayama: Hypertension and medical expenditure in the Japanese population:
Review of prospective studies., World J Cardiol., 6:531-538, 2014.

0240C004

Y.Morikawa: The issue of sleep as a risk for occupational safety, Hokuriku Japanese Journal of Public Health.,
40:17-23, 2014 (in Japanese) .

Others
0240F001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,, Y.
Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-yearrisk for type 2 diabetes mellitus in middle-aged Japanese men., Eur. J. Nutr., 53:1137-1138, 2014.

－ 24 －

Presentations at Conference
International Conference (Presentations)
0240I001

M.Sakurai, J.Kobayashi, Y.Takeda, S-Y.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi: Abdominal obesity,
metabolic syndrome, and the risk of chronic kidney disease in Japanese males and females., 74th Scientific
Sessions, American Diabetes Association., (San Francisco, '14.06).

0240I002

M.Nishijo, PT.Tai, TN.Nghi, NTN.Anh, H.Nakagawa, S.Maruzeni, HV.Luong, TH.Anh, NV.Trung, PT.Phuong, LK.
Son, T.Kido, Y.Morikawa, H.Nishijo: Effects of dioxin exposure on neurodevelopment and urinary amino acidexcretion of children in exposed areas of Vietnam., The 34th international Symposium on Halogenated Persistent
Organic pollutants-Dioxin 2014, (Madrid, '14.08).

0240I003

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, T.Kido, T.Waseda, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-pdioxin in breast milk increases autistic traits of 3-year-old children in Vietnam., The 3rd International Conferenceof Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

0240I004

TN.Nghi, HD.Manh, PT.Tai, M.Nishijo, H.Nakagawa, T.Kido, H.Nishijo: Dioxins and nonorthor polychlorinatedbiphenyl concentrations in breast milk of Vietnamese nursing mothers living in the largest hot spot of dioxin
contamination., The 3rd International Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok,'14.11).

0240I005(PT.Tai), M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Luong, TH.Anh, TN.Nghi, Y.Morikawa, T.Kido,
H.Nishijo: Dioxin effects on infant development from newborn until 3 years of age., The 3rd International
Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

0240I006

S-Y.Nagasawa, K.Miura, T.Kadowaki, A.Fujiyoshi, T.Ohkubo, S.Kadowaki, A.Kadota, A.Sekikawa, H.Ueshima:
Relationship of plasma asymmetrical dimethylarginine to carotid intima-media thickness in general population in
Japanese: the ERA-JUMP Study and SESSA Study., Nutrition,Physical Activity and Metabolism /Cardiovascular
Disease Epidemiology and Prevention 2014 Scientific Sessions, American Heart Association, (San Franscisco, '14).

－ 25 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology, Drug Dependence

Associate Professor

WANG Lu elaine

Tumor pathology, Endocrine pathology, Forensic pathology

Assistant Professor

TAKEICHI Toshiaki

ER-stress, Drug Dependence

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001(M.Takarada-Iemata), D.Kezuka, T.Takeichi, M.Ikawa, T.Hattori, Y.Kitao, O.Hori: Deletion of N-myc
downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model ofcortical stab injury, J. Neurochem., 130;374–387, 2014.

0250B002

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

－ 26 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

HORI Ariyuki

Professor

YASUDA Yukio

Senior Assistant Professor

KURODA Naohiro

Faculty

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
undergraduate clinical teaching, graduate education of physicians,
medical education
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Presentations at Conference
International Conference (Presentations)
0260I001

A.Takamura: The second evaluation for a pilot study of Community Participatory Medical Education, The Muster
2014 Global Community Engaged Medical Education, (Uluru, '14.10).

－ 27 －

Clinical

Medicine

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Professor(Additional Post)

ASAJI Takayoshi

Heart failure

Associate Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Associate Professor

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

TANABE Kan

Heart failure

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention

Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

WATANABE Makoto

Ischemic heart disease, Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system－ 28 －

Publications
Originals
0300B001

K.Tanabe, Y.Kawai, M.Kitayama, H.Akao, R.Ishida, A.Motoyama, M.Wakasa, R.Saito, H.Aoki, K.Fujibayashi,
M.Watanabe, T.Tsuchiya, H.Kimura, K.Yoshida, K.Kajinami: Increased levels of the oxidative stress marker,
nitrotyrosine in patients with provocation test-induced coronary vasospasm, J. Cardiol., 64:86-90, 2014.

0300B002

H.Akao, E.Polisecki, EJ.Schaefer, S.Trompet, M.Robertson, I.Ford, JW.Jukema, AJ.de Craen, C.Packard,
BM.Buckley, K.Kajinami: ABCA1 gene variation and heart disease risk reduction in the elderly during pravastatin
treatment, Atherosclerosis, 235:176-181, 2014.

0300B003

R.Saito, K.Takeda, K.Yamamoto, A.Nakagawa, H.Aoki, K.Fujibayashi, M.Wakasa, A.Motoyama, M.Iwadare,
R.Ishida, N.Fujioka, T.Tsuchiya, H.Akao, Y.Kawai, M.Kitayama, K.Kajinami: Nutri-pharmacogenomics of warfarin
anticoagulation therapy : VKORC1 genotype-dependent influence of dietary vitamin K intake, J. Thromb.
Thrombolysis., 38:105-114, 2014.

Presentations at Conference
International Conference (Presentations)
0300I001

K.Fujibayashi: Clinical evidence for interrelationship between Tau, Glu, and oxidative stress in atrial fibrillation,
19th International Taurine Meeting, (Krakow, '14.05).

0300I002

M.Wakasa, K.Takeda, A.Motoyama, R.Ishida, H.Akao, Y.Kawai, M.Kitayama, Y.Ueda, K.Kajinami: The longestlived homozygous familial hypercholesterolemia as geneticaly-determined mild phenotype:an autopsy case of fhtonami2, European Atherosclerosis Society 82nd EAS Congress, (Madrid, '14.05).

0300I003

W.Fujita, I. Matsunari, H.Aoki, K.Kajinami: Prediction of all-carse death using C-11 hydroxyephedrine PET inpatients with left ventricular dysfunction, SNMMI2014, (St.Louis, '14.06).

0300I004

H.Akao, M.Kitayama, Y.Kawai, T.Tsuchiya, R.Ishida, A.Motoyama, M.Wakasa, R.Saito, M.Watanabe, K.Kajinami:
Differential Role of Osteopontin and Tenascin in Atherosclerosis Coronary Rotational Atherectomy Study, 19th
World Congress on Heart Disease, (Boston, '14.07).

0300I005

T.Tsuchiya: Patients with rutherford classification Ⅳ have different characteristics and outcome, compared with Ⅴ
and Ⅵ, ESC Congress 2014, (Barcelona, '14.08).

0300I006

H.Akao: In vivo evidence for local interaction between osteopontin(OPN) and pentraxin3(PTX3) in advanced
coronary atherosclerosis : coronary rotational atherectomy study, ESC Congress 2014, (Barcelona, '14.08).

－ 29 －

0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Associate Professor

MIZUNO Shirolung cell and molecular biology，COPD

Associate
Professor(Additional Post)

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Senior Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Senior Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

KOBAYASHI Makoto lung cell and molecular biology

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

SHINOMIYA Shohei

clinical respiratory medicine

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

KAMEDA Mari

clinical respiratory medicine

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Research Doctor

KITADATE Shoko

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, T.Oikawa, M.Saito, K.Kojima, Y.Takahara,
S.Shinomiya, A.Yamaya, T.Sakuma: Assessment of bispectral index monitor during flexible bronchoscopy performed
under conscious sedation, The Journal of the Japan Society for Respiratory Endoscopy, 36:12-19, 2014.

0310B002

M.Zhou, K.Osanai, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno, Y.Muraki, H.Toga: Adenovector-mediatedgene transfer of lysophosphatidylcholine acyltransferase 1 attenuates oleic acid-induced acute lung injury in rats,
Crit. Care Med., 42:e716-e724, 2014.

－ 30 －

Case Reports
0310D001

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

Presentations at Conference
International Conference (Presentations)
0310I001

S.Mizuno, T.Ishizaki, J.G.Gomez-Arroyo, D.Kraskauskas, N.F.Voelkel, M.Kobayashi, K.Osanai, H.Toga: Gene
polymorphisms of p53 at codon 72 and mdm2 snp309 regulates cigarette smoke induced lung cell apoptosis,
American thoracic society international meeting 2014, (San diego, '14.05)，Am. J. respir. Crit. care Med.,
189:A2993, 2014.

0310I002

S.Mizuno, M.Kobayashi, T.Oikawa, K.Nakagawa, K.Osanai, M.Kadowaki, T.Ishizaki, H.Toga: Gene polymorphismsof p53 at codon 72and MDM2 SNP309 are associated with lung cancer risk and emphysematous changes insmokers, European Respiratory Society 2014 International Congress, (Munich, '14.09)，ERJ, 2014.

0310I003

R.Kato, S.Mizuno, M.Kobayashi, T.Oikawa, K.Nakagawa, K.Osanai, M.Kadowaki, T.Ishizaki, H.Toga: Platelet
endothelial cell ashesion molecule-1 expression in blood cells from patients with chronic obstructive pulmonary
disease, European Respiratory Society 2014 International Congress, (Munich, '14.09)，ERJ, 2014.

0310I004

S.Mizuno: Gene polymorphisms of p53 and MDM2 regulate emphysematous changes in COPD patients andcigarette smoke induced lung cell proliferation and apoptosis, Pulmonary Circulation Research Meeting,(Amsterdam, '14.11).

－ 31 －

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Faculty

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Senior Assistant Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Senior Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Senior AssistantProfessor(Additional Post)SHIMASAKI Takeo

Molecular Oncology, Pancreatic cancer , tissue engineering．

Assistant Professor

HAYASHI Ranji

Inflammatory Bowel Disease

Assistant Professor

NOMURA Tomoe

Gastro-intestinal disorders

Research Doctor

YAMADA Hideto

Gastro-intestinal disorders

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0320B001

K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata,T.Arisawa: The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative
colitis, Mol. Med. Report., 9:28-32, 2014.

0320B002

N.Kawada, S.Tanaka, H.Uehara, K.Ohkawa, T.Yamai, R.Takada, H.Shiroeda, T.Arisawa, Y.Tomita: Potential useof point shear wave elastography for the pancreas:A single center prospective study, Eur J Radiol., 83:620-624,
2014.

－ 32 －

0320B003(H.Kitade), T.Shimasaki, S.Igarashi, H.Sakuma, M.Mori, N.Tomosugi, M.Nakai: Long-term administration andefficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and
the GSTP1 polymorphism., Oncol. Lett., 7:1499-1502, 2014.

0320B004

N.Toshikuni, M.Tsutsumi, Y.takuma, T.Arisawa: Real-time image fusion for successful percutaneousradiofrequency ablation of hepatocellular carcinoma., J Ultrasound Med., 33:2005-2010, 2014.

0320B005

K.Ozaki, N.Toshikuni, J.George, T.Minato, Y.Matsue, T.Arisawa, M.Tsutsumi: Serum endocan as a novel
prognostic biomarker in patients with hepatocellular carcinoma, J Cancer., 5:221-230, 2014.

0320B006

T.Minato, M.Tsutsumi, M.Tsuchishima, N.Hayashi, T.Saito, Y.Matsue, N.Toshikuni, T.Arisawa, J.George: Binge
alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple
steatosis, Mol. Med., 20:490-502, 2014.

0320B007(M.Okubo), T.Tahara, T.Shibata, J.Yonemura, D.Yoshioka, Y.Kamiya, M.Nakamura, T.Arisawa, N.Ohmiya,
I.Hirata: Light blue crest and ridge/villous patterns in the uninvolved gastric antrum by magnifying NBI endoscopy
correlate with serum pepsinogen and gastric cancer occurrence, Hepatogastroenterology, 61:525-528, 2014.

0320B008(T.Tahara), T.Shibata, M.Okubo, K.Sumi, T.Ishizuka, M.Nakamura, M.Nagasaka, Y.Nakagawa, N.Ohmiya,
T.Arisawa, I.Hirata: Change in DNA methylation patterns of SLC6A4 gene in the gastric mucosa in functional,
PLoS ONE, 9:e105565;1-7, 2014.

0320B009(T.Tahara), M.Okubo, T.Shibata, T.Kawamura, K.Sumi, T.Ishizuka, M.Nagasaka, Y.Nakagawa, T.Arisawa,
N.Ohmiya, I.Hirata: Association between common genetic variants in pre-microRNAs and prognosis of advanced
gastric cancer treated with chemotherapy, Anticancer Res., 34:5199-5204, 2014.

0320B010(T.Tahara), T.Shibata, M.Okubo, T.Ishizuka, M.Nakamura, M.Nagasaka, Y.Nakagawa, N.Ohmiya, T.Arisawa,
I.Hirata: DNA methylation status of epithelial-mesenchymal transition (EMT) - related genes is associated withsevere clinical phenotypes in ulcerative colitis (UC), PLoS ONE, 9:e107947;1-7, 2014.

0320B011(T.Tahara), T.Shibata, M.Okubo, T.Ishizuka, T.Kawamura, H.Yamashita, M.Nakamura, Y.Nakagawa, M.Nagasaka,
T.Arisawa, N.Ohmiya, I.Hirata: Heat-shock protein 70-2 BB genotype is associated with reduced risks of thesteroid-dependent and refractory phenotypes of ulcerative colitis, Biomed Rep., 2:555-558, 2014.

0320B012(T.Tahara), T.Shibata, M.Okubo, T.Ishizuka, T.Kawamura, H.Yamashita, M.Nakamura, Y.Nakagawa, M.Nagasaka,
T.Arisawa, N.Ohmiya, I.Hirata: Effect of RANTES gene promoter genotypes in patients with ulcerative colitis.,
Biomed Rep., 2:602-606, 2014.

Reviews
0320C001

N.Toshikuni, T.Arisawa, M.Tsutsumi: Hepatitis C-related liver cirrhosis - strategies for the prevention of hepatic
decompensation,hepatocarcinogenesis,and mortality, World J. Gastroenterol., 20:2876-2887, 2014.

0320C002

N.Toshikuni, T.Arisawa, M.Tsutsumi: Nutrition and exercise in the management of liver cirrhosis, World J.
Gastroenterol., 20:7286-7297, 2014.

0320C003

N.Toshikuni, M.Tsutsumi, T.Arisawa: Clinical differences between alcoholic liver disease and nonalcoholic fatty
liver disease, World J. Gastroenterol., 20:8393-8406, 2014.

0320C004(T.Tahara), T.Arisawa: Pathogenesis of CpG island methylator phenotype-positive colorectal cancers; role ofgenetic alteration and colonic flora, Epigenomics., 6:249-251, 2014.

0320C005

N.Hayashi, T.Saito, M.Kakuda, Y.Matsue, T.Minato, A.Fukumura, K.Ozaki, M.Tsuchisima, M.Tsutsumi:
Pathogenesis of alcoholic chronic hepatitis, Jpn. J. Alcohol & Drug Dependence, 49:219-226, 2014 (in Japanese) .

Case Reports
0320D001(T.Tahara), T.Shibata, M.Okubo, D.Yoshioka, T.Ishizuka, K.Sumi, T.Kawamura, M.Nagasaka, Y.Nakagawa,
M.Nakamura, T.Arisawa, N.Ohmiya, I.Hirata: A case of plummer vinson syndrome showing rapid improvement ofdysphagia and esophageal web after two weeks of iron therapy., Case Rep. Gastroenterol., 8:211-215, 2014.

－ 33 －

Short Communications
0320E001

M.Nakamura, Hi.Shiroeda, T.Tahara, T.Shibata, T.Arisawa: Endoscopic submucosal dissection of an esophageal
tumor using a transnasal endoscope without sedation, Endoscopy, 46:E115-E116, 2014.

0320E002

M.Nakamura, H.Shiroeda, T.Tahara, T. Shibata, T.Arisawa: A new method using a polyglycolic acid monolayer
patch to shield the mucosal defect after endoscopic submucosal dissection, Endoscopy, 46:E176-E177, 2014.

0320E003

K.Matsunaga, R.Hayashi, T.Otsuka, D.Kaida, N.Ueda, T.Kosaka, T.Arisawa: A case of IgG4-related disease
complicated by duodenal bulbitis with IgG4-positive plasma cell infiltration, Endoscopy, 46:E408-E410, 2014.

Presentations at Conference
International Conference (Synposium)
0320H001

T.Shimasaki: Identification of the GSK3 beta-mediated secretory protein responsible for GEM-induced EMT inpancreatic cancer cells．, The 25th Annual Meeting of the Japanese Society for Gastroenterological
Carcinogenesis, (Fukuoka, '14.11).

International Conference (Presentations)
0320I001

N.Toshikuni, A.Fukumura, T.Arisawa, M.Tsutsumi: Do types of fatty liver disease influence the susceptibillity of
diabetes mellitus,hepertension,and dyslipidemia?, Didestive Disease Week 2014, (Chicago, '14.05).

0320I002(N.Kawada), K.Matsunaka, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y,Tomita: Usefulness ofdual phase 18F-FDG-PET/CT for distinguishing malignancy from benign small pancreatic tumors, Didestive
Disease Week 2014, (Chicago, '14.05).

0320I003(M.Okubo), T.Shibata, T.Tahara, Y.Ichikawa, T.Ishizuka, M.Nakamura, T.Arisawa, I.Hirata: Two weeks treatment
with esomeprazole is useful for the artifical ulcers induced by endoscopiic submucosal dissection, Didestive Disease
Week 2014, (Chicago, '14.05).

0320I004

M.Nakamura, H.Shiroeda, T.Shimasaki, N.Kawada, T,Tahara, T,Shibata, T.Arisawa: Usefulness of the packageadhesion method with four-place clip polyglycolic acid sheets for preventing bleeding from ulcers after early gastriccancer endoscopic submucosal dissection, Didestive Disease Week 2014, (Chicago, '14.05).

0320I005

M.Nakamura, H.Shiroeda, T.Shimasaki, T.Otsuka, N.Toshikuni, T.Fukuyama, K.Matsunaga, R.Hayashi, T.Nomura,
H.Yamada, K.Yamada, N.Kawada, T.Tahara, T.SHibata, T.Arisawa: The usefulness of nasal ESD performed with a
new therapeutic transnasal endoscope for early esophageal cancer, Didestive Disease Week 2014, (Chicago,'14.05).

0320I006

T.Arisawa, T.Fukuyama, T.Tahara, K.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada, T.Otsuka,
M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.SHibata: Genetic polymorphisms of DNMT3A are
associated with the aberrant DNA methylation of CDH1 in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

0320I007(T.Tahara), M.Okubo, T.Shibata, K.Sumi, T.Ishizuka, Y.Ishikawa, T.Kawamura, M.Nakamura, M.Nagasaka,
Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata: Association between common genetic variants in pre-microRNAs andprognosis of advanced gastric cancer treated chemothrapy, Didestive Disease Week 2014, (Chicago, '14.05).

0320I008

T.Shimasaki, N.Ueda, N.Kawada, T.Nomura, K.Yamada, H.Yamada, R.Hayashi, K.Matsunaga, T.Fukuyama,
T.Otsuka, M.Nakamura, N.Toshikuni, H.Shiroeda, T.Kosaka, N.Tomosugi, T.Minamoto, T.Arisawa: Phase i clinical
trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistantadvanced pancreatic cancer patients, Didestive Disease Week 2014, (Chicago, '14.05).

0320I009(N.Kawada), K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y.Tomita: NOdule sizeand positive cytology as predictors of malignancy for intraductal papillary mucinous neoplasm of the pancreas,
Didestive Disease Week 2014, (Chicago, '14.05).

－ 34 －

0320I010(N.Kawada), K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y.Tomota: Morphologicalchanges of intraductal papillary mucinous neoplasm of the pancreas are not enough for indicators of thedevelooment of pancreatic carcinoma during follow up, Didestive Disease Week 2014, (Chicago, '14.05).

0320I011(T.Tahara), T.Shibata, M.Okubo, K.Sumi, T.Ishizuka, Y.Ichikawa, T.Kawamura, M.Nakamura, N.Nagasaka,
Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata: endoscopic,clinic-pathological and molecular features of epstein-barr
virus (EB)positive gastric carcinoma, Didestive Disease Week 2014, (Chicago, '14.05).

0320I012

T.Arisawa, T.Otsuka, T.Tahara, K.Yamada, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada,
T.Fukuyama, M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.Shibata: Genetic polymorphisms of DNMT3A
are associated with the aberrant DNA methylation of DAPK in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

0320I013

T.Arisawa, H.Shiroeda, T.Tahara, K.Yamada, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada,
T.Fukuyama, T.Otsuka, M.Nakamura, N.Toshikuni, T.SHibata: A polymorphisms rs7521584 in pre-miR429 andpre-mir200s genes is associated with the aberrant DNA methylation in gastric mucosa, Didestive Disease Week
2014, (Chicago, '14.05).

0320I014(T.Tahara), T.Shibata, M.Okubo, K.Sumi, T.Ishizuka, Y.Ichikawa, T.Kawamura, M.Nakamura, M.Nagasaka,
Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata: Change in DNA methylation patterns of SLC6A4 gene in the gastricmucosa in functional dyspepsia, Didestive Disease Week 2014, (Chicago, '14.05).

－ 35 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Senior Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Assistant Professor

ADACHI Hiroki

Clinical nephrology

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Assistant Professor

OKINO Kazuaki

Clinical nephrology

Assistant Professor

MUKAI Kiyotaka

Clinical nephrology

Assistant Professor

OKUSHI Yuki

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

－ 36 －

Publications
Originals
0330B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, K.Iwabuchi, N.Tomosugi: RNA-binding protein RBM8A (Y14)and MAGOH localize to centrosome in human A549 cells., Histochem. Cell Biol., 141:101-109, 2014.

0330B002(T.Wada), M.Nangaku, S.Maruyama, E.Imai, K.Shoji, S.Kato, T.Endo, E.Muso, K.Kamata, H.Yokoyama,
K.Fujimoto, Y.Obata, T.Nishino, H.Kato, S.Uchida, Y.Sasatomi, T.Saito, S.Matsuo: A multicenter cross-sectional
study of circulating soluble urokinase receptor in Japanese patients with glomerular disease, Kidney Int., 85:641648, 2014.

0330B003(K.Takasawa), N.Tomosugi, C.Takaeda, T.Maeda, N.Ueda: Regulation of hepcidin-25 by short- and long-acting
rhEPO may be dependent on ferritin and predict the response to rhEPO in hemodialysis patients., Nephron Extra.,4:55-63, 2014.

0330B004(H.Kitade), T.Shimasaki, S.Igarashi, H.Sakuma, M.Mori, N.Tomosugi, M.Nakai: Long-term administration andefficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and
the GSTP1 polymorphism., Oncol. Lett., 7:1499-1502, 2014.

0330B005(K.Ando), K.Nitta, H.Rakugi, Y.Nishizawa, H.Yokoyama, T.Nakanishi, N.Kashihara, K.Tomita, M.Nangaku,
K.Takahashi, M.Isshiki, T.Shimosawa, T.Fujita: Comparison of the antialbuminuric effects of benidipine andhydrochlorothiazide in Renin-Angiotensin System (RAS) inhibitor-treated hypertensive patients with albuminuria:
the COSMO-CKD (COmbination Strategy on Renal Function of Benidipine or Diuretics TreatMent with RAS
inhibitOrs in a Chronic Kidney Disease Hypertensive Population) study, Int J Med Sci., 11:897-904, 2014.

0330B006

T. Takata, Y. Motoo, N. Tomosugi: Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-inducedpremature senescence of normal human dermal fibroblasts, J Integr Med., 12:495-503, 2014.

0330B007(T.Saito), M.Iwano, K.Matsumoto, T.Mitarai, H.Yokoyama, N.Yorioka, S.Nishi, A.Yoshimura, H.Sato, S.Ogahara,
H.Shuto, Y.Kataoka, S.Ueda, A.Koyama, S.Maruyama, M.Nangaku, E.Imai, S.Matsuo, Y.Tomino: Significance ofcombined cyclosporine-prednisolone therapy and cyclosporine blood concentration monitoring for idiopathic
membranous nephropathy with steroid-resistant nephrotic syndrome: a randomized controlled multicenter trial,
Clin. Exp. Nephrol., 18:784-794, 2014.

0330B009(T.Mochizuki), C.Tanji, K.Usui, S.Shoji, T.Shinomiya, M.Inaba, N.Tomosugi: A prospective study on the
improvement of EPO resistance index by better iron cycling with lower ferritin management in hemodialysis
patients(EPOCH study), J. Jpn. Soc. Dial. Ther., 47:313-321, 2014 (in Japanese) .

Reviews
0330C001(M.Shimizu), K.Furuichi, H.Yokoyama, T.Toyama, Y.Iwata, N.Sakai, S.Kaneko, T.Wada: Kidney lesions in diabetic
patients with normoalbuminuric renal insufficiency, Clin. Exp. Nephrol., 18:305-312, 2014.

Case Reports
0330D001

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

Presentations at Conference
International Conference (Synposium)
0330H001(R.Yamamoto), S.Maruyama, H.Yokoyama, S.Matsuo, E.Imai: Japan nephrotic syndrome cohort study(JNSCS):anationwide prospective cohort study of primary nephrotic syndrome in Japan, 2014 Asian Pacific Society ofNephrology, (Tokyo, '14.05).

－ 37 －

International Conference (Presentations)
0330I001

K.Fujimoto, K.Mukai, Y.Okushi, K.Okino, K.Shojima, Y.Matsui, H.Atsumi, H.Adachi, H.Okuyama, H.Yamaya,
H.Yokoyama: Clinical significance of serum soluble urokinase receptor (suPAR) levels in primary nephrotic
syndrome, 2014 Asian Pacific Society of Nephrology, (Tokyo, '14.05).

0330I002

H.Adachi, K.Mukai, Y.Okushi, K.Okino, K.Shojima, Y.Matsui, K.Fujimoto, H.Atsumi, H.Okuyama, H.Yamaya,
H.Yokoyama: Renoprotective effects of HDL-C and adiponectin in patients with renal allograft, 2014 Asian PacificSociety of Nephrology, (Tokyo, '14.05).

0330I003

H.Atsumi, Y.Okushi, K.Okino, K.Mukai, Y.Matsui, K.Fujimoto, H.Adachi, Y.Chikazawa, H.Okuyama, H.Yamaya,
H.Yokoyama: The long-term outcome of Japnnese renal allograft recipients with hepatitis C viral infection, 2014
Asian Pacific Society of Nephrology, (Tokyo, '14.05).

0330I004(R.Yamamoto), S.Maruyama, H.Yokoyama, S.Matsuo, E.Imai: Resistance to immunosuppressive therapy in primary
nephrotic syndrome:Japan nephrotic syndrome cohort study(JNSCS), 2014 Asian Pacific Society of Nephrology,(Tokyo, '14.05).

0330I005

N.Hayashi, S.Akiyama, H.Okuyama, Y.Matsui, K.Fujimoto, H.Atsumi, H.Adachi, H.Yamaya, S.Maruyama, E.Imai,
S.Matsuo, H.Yokoyama: Clinical and pathological characteristics of the M-type phospholipase A2 receptor(PLA2R) related me, 51st ERA-EDTA Congress in Amsterdam The Netherlands, (Amsterdam, '14.06).

0330I006

K.Fujimoto, H.Adachi, H.Okuyama, H.Yamaya, H.Yokoyama: Urinary and serum soluble urokinase receptor levels
predicts the therapeutic responsiveness of nephrotic syndrome and ANCA-glomerulonephritis, The Annual of
American Sociey of Nephrology, (Philadelphia, '14.11).

0330I007

Y.Matsui, H.Atsumi, J.Imura, K.Fujimoto, H.Adachi, H.Okuyama, H.Yamaya, H.Yokoyama: DNA double strand
brakes induced intractable glomerular fibrosis in renal allografts, The Annual of American Sociey of Nephrology,(Philadelphia, '14.11).

0330I008(H.Komatsu), S.Fujimoto, N.Yoshikawa, H.Kitamura, H.Sugiyama, H.Yokoyama: Comparison of cinicalmanifestations between henöch-schönlein purpura nephritis and IgA nephropathy:analysis of Japan renal biopsy
registry (J-RBR), The Annual of American Sociey of Nephrology, (Philadelphia, '14.11).

－ 38 －

0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Senior Assistant Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Assistant Professor

ITO Hiroki

diabetes

Assistant Professor

KANASAKI Megumi

diabetes, hypertension, obesity, preeclampsia

Assistant Professor

OTODA Toshiki

diabetes，obesity

Assistant Professor

ASTUMI Hisanari

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001

T.Nagai, M.Kanasaki, SP.Srivastava, Y.Nakamura, Y.Ishigaki, M.Kitada, S.Shi, K.Kanasaki, D.Koya: N-acetylseryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition,
Biomed Res Int., 2014:696475;1-12, 2014.

－ 39 －

0340B002(FA.Pena), K.Kanasaki, M.Kanasaki, S.Vong, C.Rovira, R.Kalluri: Specific activation of K-rasG12D allele in the
bladder urothelium results in lung alveolar and vascular defects, PLoS ONE, 9:e95888;1-9, 2014.

0340B003(M.Yasuda), Y.Tanaka, S.Kume, Y.Morita, M.Chin-Kanasaki, H.Araki, K.Isshiki, S.Araki, D.Koya, M.Haneda,
A.Kashiwagi, H.Maegawa, T.Uzu: Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal
localization and apoptosis in podocytes, BBA. Mol. Basis Dis., 1842:1097-1108, 2014.

0340B004(S.Kume), S.Araki, N.Ono, A.Shinhara, T.Muramatsu, H.Araki, K.Isshiki, K.Nakamura, H.Miyano, D.Koya,
M.Haneda, S.Ugi, H.Kawai, A.Kashiwagi, T.Uzu, H.Maegawa: Predictive properties of plasma amino acid profile for
cardiovascular disease in patients with type 2 diabetes, PLoS ONE, 9:e101219;1-7, 2014.

0340B005

K.Kanasaki, S.Shi, M.Kanasaki, J.He, T.Nagai, Y.Nakamura, Y.Ishigaki, M.Kitada, SP.Srivastava, D.Koya:
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice byinhibiting endothelial-to-mesenchymal transition in a therapeutic regimen, Diabetes, 63:2120-2131, 2014.

Reviews
0340C001

M.Kitada, S.Kume, D.Koya: Role of sirtuins in kidney disease, Curr. Opin. Nephrol. Hypertens., 23:75-79, 2014.

0340C002(S.Kume), K.Yamahara, M.Yasuda, H.Maegawa, D.Koya: Autophagy: emerging therapeutic target for diabetic
nephropathy, Semin. Nephrol., 34:9-16, 2014.

0340C003

D.Koya, M.Kitada, S.Kume, K.Kanasaki: Interventions against nutrient-sensing pathways represent an emerging
new therapeutic approach for diabetic nephropathy, Clin. Exp. Nephrol., 18:210-213, 2014.

0340C004

K.Kanasaki, T.Nagai, K.Nitta, M.Kitada, D.Koya: N-acetyl-seryl-asparatyl-lysyl-proline: a valuable endogenous
anti-fibrotic peptide for combating kidney fibrosis in diabetes, Front Pharmacol., 5:1-11, 2014.

0340C005

S.Shi, Y.He, D.Koya, K.Kanasaki: Cancer biology in diabetes, J Diabetes Investig, 5:251-264, 2014.

0340C006(Japanese Society of Nephrology), K.Kanasaki, M.Kitada, D.Koya: Evidence-based clinical practice guideline for
CKD 2013, Clin. Exp. Nephrol., 18:346-423, 2014.

0340C007

M.Kitada, K.Kanasaki, D.Koya: Clinical therapeutic strategies for early stage of diabetic kidney disease, World J
Diabetes., 5:342-356, 2014.

0340C008(C.Gao), W.Huang, K.Kanasaki, Y.Xu: The role of ubiquitination and sumoylation in diabetic nephropathy, Biomed
Res Int., 2014:160692;1-11, 2014.

0340C009(S.Kume), D.Koya, T.Uzu, H.Maegawa: Role of nutrient-sensing signals in the pathogenesis of diabetic
nephropathy, Biomed Res Int., 2014:315494;1-9, 2014.

0340C010

T.Otoda, K.Kanasaki, D.Koya: Low-protein diet for diabetic nephropathy, Curr. Diab. Rep., 14:523;1-10, 2014.

0340C011

SP.Srivastava, S.Shi, D.Koya, K.Kanasaki: Lipid mediators in diabetic nephropathy, Fibrogenesis Tissue Repair,
7:1-10, 2014.

0340C012(M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa,
M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide: A new classification ofdiabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Diabetol Int., 5:207-211, 2014.

0340C018(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K,Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K.Shide: Classification of diabetic nephropathy 2014, J. Jpn. Soc. Dial. Ther., 47:415-419, 2014 (inJapanese) .

0340C019(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K,Shide: Classification of diabetic nephropathy 2014, Jpn. J. Nephrol., 56:547-552, 2014 (inJapanese) .

－ 40 －

0340C025(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K.Shide: Classification of diabetic nephropathy 2014, The Journal of Metabolism and Clinical Nutrition,
17:325-330, 2014 (in Japanese) .

Short Communications
0340E001

K.Kanasaki, A.Maeshima, G.Taduri, I.Revuelta: Combating kidney fibrosis, Biomed Res Int., 2014:679154;1-2,
2014.

Others
0340F001

D.Koya: Dual protein kinase C alpha and beta inhibitors and diabetic kidney disease: a revisited therapeutic target
for future clinical trials, J Diabetes Investig, 5:147-148, 2014.

0340F002(T.Gohda), A.Mima, JY.Moon, K.Kanasaki: Combat diabetic nephropathy: from pathogenesis to treatment, J
Diabetes Res., 2014:207140;1-2, 2014.

0340F005

M.Kitada: Elucidation of the mechanisms of diabetic nephropathy, Diabetic Complications, 28:155-163, 2014 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
0340H001

K.Kanasaki: Workshop1 Pathophysiology of PE: I Pathogenesis of preeclampsia: COMT deficiency and relevans,
The 46th International Congress on Pathophysiology of Pregnancy, (Tokyo, '14.09).

0340H002

D.Koya: Symposium7 Aging and metabolism Metabolic changes in aging Nutrient sensing and metabolic health,2014 International Conference on Diabetes and Metabolism, (Gyeonggido, '14.10)，2014 International Conference
on Diabetes and Metabolism abstract book, 65, 2014.

International Conference (Presentations)
0340I001

K.Konishi, S.Nakano, H.Ito, S.Tsuda, M.Kitada, K.Kanasaki, M.Nishizawa, A.Nakagawa, D.Koya: AST-120
ameliorates vascular endothelial dysfunctions and atherosclerosis in type 2 diabetic subjects with overt
nephropathy, The 8th International Congress on Uremia Research and Toxicity, (Okinawa, '14.03)，The 8thInternational Congress on Uremia Research and Toxicity Program and Abstract, 90, 2014.

0340I002

S.Shi, M.Kanasaki, T.Nagai, SP.Srivastava, K.Kanasaki, D.Koya: Linagliptin-mediated DPP-4 inhibition
ameliorates kidney fibrosis and endothelial-to-mesenchymal transition in streptozotocin-induced diabetic mice inassociated with restration of microRNA 29s, The 14th Asian Pacific Congress of Nephrology 2014, (Tokyo,'14.05)，Nephrology, 19:(Suppl.S2) 44, 2014.

0340I003

K.Kanasaki, M.Kanasaki, S.Shi, SP.Srivastava, D.Koya: Linagliptin-mediated DPP-4 inhibition ameliorates kidney
fibrosis in streptozotocin-induced diabetic mice via restoring microRNA29s, American Diabetes Association 74rd
Scientific Sessions, (San Francisco, '14.06).

0340I004(N.Ueki), S.Takeda, D.Koya, K.Kanasaki: Deficiency in catechol-o-methyltransferase is associated with glucose
intolerance, The 46th International Congress on Pathophysiology of Pregnancy, (Tokyo, '14.09)，Abstracts for the
46th International Congress on Pathophysiology of Pregnancy, 90, 2014.

0340I005

K.Kanasaki, SP.Srivastava, D.Koya: The antifibrotic microRNA crosstalk in the action of N-acetyl-seryl-aspartyllysyl-proline, Cell Symposia: Regulatory RNAs 2014, (Berkeley, '14.10).

0340I006

D.Koya, K.Kanasaki, M.Kitada: The antifibrotic microRNA crosstalk in the action of N-acetyl-seryl-aspartyllysyl-proline, The 10th International Diabetes Federation-Western Pacific Region Congress / 6th the Asian
Association for the Study of Diabetes, (Singapore, '14.11)，Diabetes Res. Clin. Pract. Suppl., 106:(Suppl.1) S123124, 2014.

－ 41 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

TANAKA Masao

Rheumatology, Immunology

Associate Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Senior Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Senior Assistant Professor

OGISO Hideo

Hematology and Immunology

Senior Assistant Professor

TSUKAHARA Tamotsu Hematology and Immunology

Assistant Professor

KAWANAMI Haruka

Hematology and Immunology

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

NAKAJIMA Akio

Hematology and Immunology

Assistant Professor

NAKAMURA Takuji

Hematology and Immunology

Assistant Professor

MIKI Miyuki

Hematology and Immunology

Assistant Professor

UEDA Yoshibumi

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
Studies of immunological abnormalities and pathophysiology of autoimmune diseases:
1 Effects of chemokines on vascular injury and Th1 response during chronic inflammation.
2 Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases.
3 Analysis of immunological disorder in sphingomyelin knockout mice.
4 Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis.
5 Detection of stem cells in salivary glands and its implication for regenerative medicine.
Studies of hematological malignancies and development of anti-cancer drugs:
1 Analysis of EB-virus proteins and their roles in lymphoproliferative disorders.
2 Molecular biological analysis of drug resistance.
3 Roles of sphingomyelin on apoptosis.
4 Roles of SMS on niche of leukemia stem cells.

－ 42 －

Books
0350A005

Y.Masaki, N.Kurose, H.Tonami, H.Umehara: Other organs(central nervous system,prostate), IgG4-RelatedDisease(H.Umehara, K.Okazaki, JH.Stone, S.Kawa, M.Kawano), 113-117, Springer Japan, Tokyo, 2014.

0350A006

H.Umehara, T.Okazaki: Comprehensive diagnostic criteria for IgG4-related disease, IgG4-RelatedDisease(H.Umehara, K.Okazaki, JH.Stone, S.Kawa, M.Kawano), 35, Springer Japan, Tokyo, 2014.

Publications
Originals
0350B001

H. Ogiso, M. Taniguchi, S. Araya, S.Aoki, LO.Wardhani, Y. Yamashita, Y. Ueda, T.Okazaki: Comparative analysisof biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS/MS, Metabolites., 4:98-114,
2014.

0350B002(N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami,
Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara: Long-term heat exposure prevents hypoxiainduced apoptosis in mouse fibroblast cells, Cell Biochem. Biophys., 70:301-307, 2014.

0350B003

Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka,
Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara: Deficient leptin signaling ameliorates systemic lupus
erythematosus lesions in MRL/Mp-Faslpr mice, J. Immunol., 192:979-984, 2014.

0350B004(H.Umehara), A.Nakajima, T.Nakamura, T.Kawanami, M.Tanaka, L.Dong, M.Kawano: IgG4-related disease and its
pathogenesis-cross-talk between innated and acquired immunity, Int. Immunol., 26:585-595, 2014.

0350B005(I.Mizushima), D.Inoue, M.Yamamto, K.Yamada, T.Saeki, Y.Ubara, S.Matsui, Y.Masaki, T.Wada, S.Kasashima,
K.Harada, H.Takahashi, K.Notohara, Y.Nakamura, H.Umehara, M.Yamagishi, M.Kawano: Clinical course after
corticosteroid therapy in IgG4-related aortitis/preiaortitis and periarteritis: a retrospective multicenter study,
Arthritis Res. Ther., 16:R156;1-11, 2014.

Reviews
0350C001

M. Taniguchi, T. Okazaki: The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation andmigration – from cell and animal models to human disorders-, BBA-MOL CELL BIOL L, 1841:692-703, 2014.

0350C002

Y.Masaki, H.Shimizu, T.Sato, T.Nakamura, A.Nakajima, H.Iwao, M.Miki, T.Sakai, T.Kawanami, Y.Fujita,
M.Tanaka, T.Fukushima: IgG4-related disease:Diagnostic methods and therapeutic strategies in Japan, J. Clin.
Exp. Hematop., 54:95-101, 2014.

Case Reports
0350D001(K.Fujiwara), T.Fukuhara, H.Kitano, T.Okazaki: Infiltration of the thyroid Gland by T-cell prolymphocytic
leukemia, Thyroid., 24:1314-1318, 2014.

Presentations at Conference
International Conference (Presentations)
0350I001

M. Taniguchi, K. Kitatani, Y. Taguchi, T. Kawanami, T. Takegami, H. Umehara, T. Okazaki: Lysosomal ceramide
generated by acid sphingomyelinase triggers cathepsin B-mediated apoptosis in IL-2-deprived natural killer cells,
Gordon Research Conferences, Glycolipid & Sphingolipid Biology, (Ventura, '14.01).

0350I002

M. Taniguchi, H. Ogiso, Y. Kitagawa, K. Hori, Y. Yamashita, S. Araya, S. Mitsutake, Y. Igarashi, T. Okazaki, T.
Takegami: Deficiency of sphingomyelin synthase 1 prevents attachment and infection of Japanese Encephalitis
Virus, 2nd International Workshop on Molecular Medicine of Sphingolipids, (Kloster Banz,, '14.10).

－ 43 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Professor(Additional Post)

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TOMIOKA Ryo

Clinical neurology, Neuroimmunology

Associate Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

FUJITA Michiyo

Clinical neurology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(E.Tabata), M.Masuda, M.Eriguchi, M.Yokoyama, Y.Takahashi, K.Tanaka, M.Yukitake, E.Horikawa, H.Hara:
Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor
encephalitis, Eur. Neurol., 71:42-48, 2014.

0360B002(M.Akaza), K.Tanaka, M.Tanaka, T.Sekiguchi, T.Misawa, K.Nishina, I.Kawachi, M.Nishizawa, H.Mizusawa,
T.Yokota: Can anti-AQP4 antibody damage the blood-brain barrier?, Eur. Neurol., 72:273-277, 2014.

0360B003(K.Park), K.Tanaka, M.Tanaka: Uhthoff's phenomenon in multiple sclerosis and neuromyelitis optica, Eur. Neurol.,
72:153-156, 2014.

0360B004(K.Kanazawa), R.Matsumoto, A.Shimotake, M.Kinoshita, A.Otsuka, O.Watanabe, K.Tanaka, R.Takahashi, A.Ikeda:
Persisitnt frequent subclinical seizures and memory impairment after clinical remission in smoldering limbic
encephalitis, Epileptic Disord., 16:312-7, 2014.

Reviews
0360C001

M.Matsui, Y.Shimizu, H.Doi, R.Tomioka, I.Nakashima, M.Niino, J.Kira: Japanese guidelines for fingolimod in
multiple sclerosis:putting into practice, Clin. Exp. Neuroimmunol., 5:34-48, 2014.

0360C002

R.Tomioka, M.Matsui: Biomarkers for multiple sclerosis, Intern. Med., 53:361-365, 2014.

0360C005

M.Matsui: Prevention of relapse in multiple sclerosis:fingolimod and interferon-β, Neurol Therap, 31:188-192,
2014 (in Japanese) .

－ 44 －

0360C007

K.Tanaka: Diagnosis and treatment of paraneoplastic neurologic syndrome, Neurol Therap, 31:153-155, 2014 (inJapanese) .

0360C013

K.Tanaka: Pathogenesis of autoantibodies in demyelinating disorders of the central nervous system, Japanese
Journal of Clinical Medicine, 72:2067-2072, 2014 (in Japanese) .

0360C014

R.Tomioka, M.Matsui: Multiple sclerosis:diagnosis,clinical course and differential diagnosis, Japanese Journal of
Clinical Medicine, 72:1957-1963, 2014 (in Japanese) .

Case Reports
0360D001(M.Miyamoto), M.Kinoshita, K.Tanaka, M.Tanaka: Recurrent myeliltis in localized scleroderma, Clin. Neurol.
Neurosurg., 127:140-142, 2014.

0360D002(Y.Yamaguchi), K.Furukawa, T.Yamamoto, Y.Takahashi, K.Tanaka, M.Takahashi: Multifocal encephalopathy andautoimmune-mediated limbic encephalitis following tocilizumab therapy, Intern. Med. J., 53:879-82, 2014.

0360D003(M.Nishio), N.Nishitani, K.Tanaka: A case of acute limbic encephalitis with cerebral salt wasting syndrome, Clinical
Neurology, 54:657-659, 2014 (in Japanese) .

0360D004(D.Yamamoto), T.Uchiyama, T.Bunai, K.Sato, T.Shimizu, K.Tanaka, T.Ohashi: Acute encephalitis with refractory
partial status epilepticus treated with early immunotherapies including plasma exchange:a case report, Clinical
Neurology, 54:715-720, 2014 (in Japanese) .

0360D005(M.Tanaka), K.Tanaka: Relapse in a patient with multiple sclerosis 18months after natalizumab treatment withoutanti-natalisumab neutralizing antibodies, Neurological Medicine, 81:582-584, 2014 (in Japanese) .

Short Communications
0360E001(M.Tanaka), K.Tanaka: Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous
system, J. Neuroimmunol., 270:98-99, 2014.

Others0360F001(M.Tanaka), K.Tanaka: Dose reduction therapy of fingolimod for Japanese patients with multiple sclerosis:24month experience, Clin. Exp. Neuroimmunol., 5:383-384, 2014.

0360F002(K.Fujita), K.Tanaka, Y.Takahashi: Neuronal antibodies in creutzfeldt-jakob disease, JAMA Neurol., 71:514-515,
2014.

0360F003(T.Kezuka), Dk. Sato, K.Tanaka: Distinction between MOG antibody-positive and AQP4 antibody-positive NMO
spectrum disorders, Neurology, 83:475-476, 2014.

Presentations at Conference
International Conference (Presentations)
0360I001

K.Tanaka, Y.Li, L.Li Wang, N.Kato, M.Matsui, T.Takegami: Memory disturbance of the mice treaｔed withintraventricular administration of CSF from NMDAR-encephalitis patients, American Academy of Neurology 2014
Aunual Meeting, (Philadelphia, '14.05).

－ 45 －

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0363B001

T. Takata, Y. Motoo, N. Tomosugi: Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-inducedpremature senescence of normal human dermal fibroblasts, J Integr Med., 12:495-503, 2014.

0363B002

Y.Motoo, I.Arai, K,Tsutani: Use of Kampo diagnosis in randomized controlled trials of Kampo products in Japan: asystematic review, PLoS ONE, 9:e104422;1-9, 2014.

0363B004

Y.Matsui, R.Murayama, H.Tanabe, M.Oe, M.Fukuda, Y.Motoo, T.Wagatsuma, S.Kinoshita, K.Sakai, C.Konya,
J.Sugama, H.Sanada: Analysis of thermographic images in an extravasation model of intravenous infusion in healthy
adults, Journal of Nursing Science and Engineering, 1:4-11, 2014 (in Japanese) .

0363B005(K.Tsutani), K.Yukawa, M.Nagasawa, I.Arai, A.Igarashi, H.Ogasawara, K.Tsuruoka, S.Fukuyama, Y.Motoo,
Y.Yamazaki: Survey on health hazards indirectly caused by complementary and alternative medicine in Japan,
Japanese Pharmacology & Therapeutics., 42:1005-1014, 2014 (in Japanese) .

Case Reports
0363D001

J.Moriya, K.Takeuchi, H.Uenishi, S.Akazawa, Y.Motoo, H.Hashimoto, M.Kaneshima, J.Kobayashi, J.Yamakawa:
Successful treatment of post-influenza chronic fatigue syndrome with kampo medicine:a case report, Japanesejournal of oriental medicine., 65:87-93, 2014 (in Japanese) .

0363D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi: Treatment with kampo medicines fo reflex sympathetic
dystrophy, post-optic nerve meningioma operation and traffic injury, Pain and kampo medicine., 24:144-148, 2014
(in Japanese) .

Others
0363F001(T.Efferth), S.Lee, Y.Motoo, S.Schröder: Acupuncture and herbal medicine for cancer patients 2014, Evid BasedComplement Alternat Med, 2014,326179;1-2, 2014.

－ 46 －

Presentations at Conference
International Conference (Synposium)
0363H001

Y.Motoo: Role of Kampo medicine in multidisciplinary cancer therapy, 2014 Workshop on Integrative Medicine,
Association of Korean Integrative Medicine (AKIM), (Seoul, '14.02).

0363H002

Y.Motoo: Advancements and challenges relevant to integrative traditional and modern medicine in the world:
Japan, 2014 Integrative Traditional and Modern Medicine International Forum, (Taipei, '14.11).

International Conference (Presentations)
0363I001

Y.Motoo: Integrative cancer medicine in Japan, 2014 International Conference on Integrative Medicine,
Association of Korean Integrative Medicine (AKIM), (Seoul, '14.02).

0363I002

Y.Motoo, I.Arai, K.Tsutani: Use of Kampo diagnosis in randomized controlled trials of Kampo products in Japan: asystematic review, 2014 Integrative Traditional and Modern Medicine International Forum, (Taipei, '14.11).

－ 47 －

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

BABA Hisashi

Clinical Infectious Diseases, Infection Control and Prevention,
Clinical Microbiology

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001(Y.Matsumura), Y.Ito, M.Yamamoto, A.Matsushima, M.Nagao, S.Takakura, Y.Iinuma, S.Ichiyama: Pneumocystis
polymerase chain reaction and blood (1→3)-β-D-glucan assays to predict survival with suspected Pneumocystis
jirovecii pneumonia., J. Infect. Chemother., 20:109-114, 2014.

0366B003

K.Matsuura, H.Baba, M.Asou, E.Morita, K.Kanaya, K.Kawamura, Y.Iinuma: Fundamental assessment of the
CHROMagarTM MDRP medium in the screening of multidrug-resistant Pseudomonas aeruginosa, Japanese Journalof Medical Technology, 63:226-231, 2014 (in Japanese) .

Others
0366F001(A.Suwabe), M.Maekawa, M.Koshiba, H.Baba, Y.Iinuma, K,Izuhara, Y.Furukawa, Y.Tanaka, K,Furuichi, T.Wada,
H.Yoshida, H.Harigae, N.Watanabe, I.Kitajima: Points of revision of the guideline JSLM 2012, Rinsho Byori,
62:702-709, 2014 (in Japanese) .

－ 48 －

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Associate Professor

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology

Associate Professor

YAMAKAWA Junichi

General medicine, Kampo medicine

Senior Assistant Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Senior AssistantProfessor(Additional Post)

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0368B001(N.Ito), K.Yagi, M.Kawano, Y.Mori, S.Okazaki, D.Chujo, Y.Takeda, J.Kobayashi, M.Yamagishi: Analysis ofpancreatic endocrine function in patients with IgG4-related diseases, in whom autoimmune pancreatitis was ruledout by diagnostic imaging, Endocr. J., 61:765-772, 2014.

0368B002(A.Nohara), J.Kobayashi, MA.Kawashiri, H.Tada, A.Inazu, M.Jiang, H.Mabuchi, H.Bujo: Clinical significance ofmeasuring soluble LR11, a circulating marker of atherosclerosis and HbA1c in familial hypercholesterolemia, Clin.
Biochem., 47:1326-1328, 2014.

0368B003(H.Uzui), H.Hayashi, I.Nakae, T.Matumoto, H.Uenishi, H.Hayasaki, T.Asaji, S.Matsui, M.Kunihisa, JD.Lee,
H.Tada, T.Sawamura, M.Fujita: Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in
CD14-positive mononuclear cells in hypercholesterolemic patients, Int. J. Cardiol., 176:1230-1232, 2014.

Reviews
0368C001

K.Nakajima, J.Kobayashi: Antibodies to human angiopoietin-like protein 3:a patent evaluation of WO2012174178,
Expert Opin Ther Pat., 24:113-119, 2014.

Case Reports
0368D001

J.Moriya, K.Takeuchi, H.Uenishi, S.Akazawa, Y.Motoo, H.Hashimoto, M.Kaneshima, J.Kobayashi, J.Yamakawa:
Successful treatment of post-influenza chronic fatigue syndrome with kampo medicine:a case report, Japanesejournal of oriental medicine., 65:87-93, 2014 (in Japanese) .

－ 49 －

0368D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi: Treatment with kampo medicines fo reflex sympathetic
dystrophy, post-optic nerve meningioma operation and traffic injury, Pain and kampo medicine., 24:144-148, 2014
(in Japanese) .

0368D003(K.Takeuchi), M.Kitamura, T.Isada, R.Saito, S.Shine, J.Moriya, J.Yamakawa: Successful treatment with tokito andpregabalin in a patient suffering from postthoracotomy pain, Pain and kampo medicine., 24:93-95, 2014 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0368I001

J.Kobayashi, K.Miyashita, S.Imamura, N.Kinoshita, K.Stanhope, P.Havel, K.Nakajima, T.Machida, H.Sumino,
M.Nara, M.Murakami: A New enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase,The 2nd world congress of clinical lipidology, (Wien, '14.05).

0368I002

K.Nakajima, K.Miyashita, S.Imamura, J.Kobayashi, T.Shirakawa, S.Yatsuzuka, Y.Shimomura, T.Machida, H.Sumino,
M.Murakami: More than 80% of circulating lipoprotein lipase in pre-heparin plasma is found in remnant
lipoproteins, The 82nd Congress of the European Atherosclerosis Society(EAS), (Madrid, '14.05)，Atherosclerosis,
235:e84, 2014.

0368I003

M.Sakurai, J.Kobayashi, Y.Takeda, S-Y.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi: Abdominal obesity,
metabolic syndrome, and the risk of chronic kidney disease in Japanese males and females., 74th Scientific
Sessions, American Diabetes Association., (San Francisco, '14.06).

－ 50 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor(Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Associate Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

MORITA Takuro

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

OKUNO Tazuo

Geriatrics, Circulation

Assistant Professor

HIMENO Taro

Geriatrics, Circulation

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

O.Iritani, Y.Koizumi, Y.Hamazaki, H.Yano, T.Morita, T.Himeno, T.Okuno, M.Okuro, K.Iwai, S.Morimoto:
Association between blood pressure and disability-free survival among community-dwelling elderly patients
receiving antihypertensive treatment, Hypertens. Res., 37:772-778, 2014.

0370B002(M.Sato), Y.Sagawa, N.Hirai, S.Sato, M.Okuro, S.Kumar, T.Kanbayashi, T.Shimizu, N.Sakai, S.Nishino:
Noninvasive detection of sleep/wake changes and cataplexy-like behaviors in orexin-3 transgenic narcoleptic mice
across the disease onset, J. Neuropathol. Exp. Neurol., 261:744-751, 2014.

0370B003

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

Reviews
0370C001

M.Okuro, S.Morimoto: Sleep apnea in the elderly, Curr Opin Psychiatry., 27:472-477, 2014.

－ 51 －

Presentations at Conference
International Conference (Presentations)
0370I001

K.Iwai, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF regulates the formationof apoptosis by conjugating the two opposite pathways in arterial smooth muscle cell, European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35 (Suppl.) ：612-613, 2014.

0370I002

K.Iwai, T.Okuno, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF isprerequisite for the fetal gene expression in the process of hypertrophy of the cardiomyocyte., European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35：(Suppl.) 954-955, 2014.

0370I003

K.Iwai, T.Okuno, T.Morita, O.Iritani, M.Okuro, S.Morimoto: Nucleostemin and Nucleophosmin Express with Upregulating Telomere Reverse Transcriptase in the Arteriosclerotic Lesions, Scientific Sessions 2014, American
Heart Association, (Chicago, '14.11)，Circulation, 130(Suppl)：A17204, 2014.

－ 52 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITO Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Senior Assistant Professor

FUJIKI Takuma

Pediatric nephrology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

OGURI Masato

Pediatric cardiology.

Assistant Professor

YAMASHITA Yoko

Pediatric allergy, Pediatric immunology.

Assistant Professor

KOH Giyo

Connective tissue disease

Assistant Professor

IKENO Kanjyu

Child neurology

Research Doctor

YAMAMOTO Akiko

Child neurology

Research Doctor

FUJII Kunihiro

Pediatric Hematology, Inherited Metabolic Disease

Research Doctor

HORI Suiko

Pediatric allergy, Pediatric immunology.

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(H.Kohno), F.Ichida, K.Hirono, S.Ozawa, N.Yoshimura, T.Nakamura, C.Akita, K.Ishida, M.Taguchi: Plasma
concentrations of tadalafil in children with pulmonary arterial hypertension, Ther Drug Monit., 36:576-583, 2014.

0380B002

M.Oguri, T.Nakamura, K.Tamanuki, C.Akita, C.Kitaoka, Y.Saikawa, M.Takahashi: Subclinical arterial stiffness inyoung children after Kawasaki disease, Cardiol Young, 24:87-94, 2014.

－ 53 －

Case Reports
0380D001

T.Nakamura, K.Tamanuki, G.Koh, M.Oguri, C.Akita, C.Kitaoka, T.Nakamura, Y.Saikawa: Chronic thromboembolic
pulmonary hypertension related to hemangiolymphangioma, Case Reports in Clinical Medicine., 3;36-37, 2014.

0380D002

N.Okamoto, G.Ko, M.Oguri, C.Akita, N.Okada, T.Nakamura, Y.Saikawa: A case of Kawasaki disease thatdeveloped during the follow-up of PFAPA, Progress in Medicine, 34:1236-1239, 2014 (in Japanese) .

0380D003

S.Toki, G.Ko, M.Oguri, C.Akita, N.Okada, T.Nakamura, Y.Saikawa: Two cases of patients developing Kawasaki
disease after diagnosis of autoimmune neutropenia, Progress in Medicine, 34:1240-1244, 2014 (in Japanese) .

Short Communications
0380E001(T.Wada), M.Ito, H.Maeba, T.Toma, Y.Niida, Y.Saikawa, A.Yachie: Intermittent X-Linked thrombocytopenia witha novel WAS gene mutation, Pediatr Blood Cancer, 61:746-748, 2014.

Others0380F001(NE.Bowles), CB.Arrington, K.Hirono, T.Nakamura, L.Ngo, YS.Wee, F.Ichida, JH.Weis: Kawasaki disease patientshomozygous for the rs12252-C variant of interferon-induced transmembrane protein-3 are significantly more likely
to develop coronary artery lesions, Mol Genet Genomic Med., 2:356-361, 2014.

－ 54 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

UEHARA Takashi

Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Senior Assistant Professor

MONKAWA Akikazu

Brain imaging, Schizophrenia

Senior Assistant Professor

MONKAWA Tomomi

Psychopharmacology, Neuropsychology

Assistant Professor

KOSEKI Yojyu

Brain imaging

Assistant Professor

NITTA Yusuke

Consultation liaison psychiatry

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Assistant Professor

KIHARA Hiroaki

Brain imaging,，Schizophrenia

Assistant Professor

SHIMADA Takamitsu Brain imaging,，Schizophrenia

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001(J.Matsumoto), T.Uehara, S.Urakawa, Y.Takamura, T.Sumiyoshi, M.Suzuki, T.Ono, H.Nishijo: 3D video analysis of
the novel object recognition test in rats, Behav. Brain Res., 272:16-24, 2014.

0390B002

T.Uehara, T.Matsuoka, T.Sumiyoshi: Tandospirone,a 5-HT 1A partial agonist ameliorates aberrant lactate
production in the prefrontal cortex of rats exposed to blockade of N-methy-D-aspartate receptors;Toward thetherapeutics of cognitive impairment of schizophrenia, Front Behav Neurosci., 8:291;1-8, 2014.

0390B003

H.Kihara: The influence of a familial history of mood disorder on the findings of near-infrared spectroscopy forbipolar disorder, J. Kanazawa. Med. Univ., 39:26-33, 2014 (in Japanese) .

－ 55 －

0390B005

T.Shimada: An investigation into the brain structure and function of patients with schizophrenia using MRI andNIRS, J. Kanazawa. Med. Univ., 39:1-9, 2014 (in Japanese) .

0390B006

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0390I001

Y.Kawasaki, R.Hashimoto, S.ono, T.Shimada, H.Kihara, Y.Matsuda, M,Tunoda: Early detection and intervention
project for young people at risk for developing psychosis in Uchinada, 4rd Biennial Schizophrenia International
Research Society Conference, (Florence Italy, '14.04).

0390I002

Y.Matsuda, Y.Kawasaki, T,Takahashi, M.Kido, K.Nakamura, A.Furuichi, M.Suzuki: Gyrification of Superior
Temporal Gyrus Schizophrenia :Possibility of Clinical Application, OHBM 2014 Annual Meeting,(Hamburg,Germany, '14.06).

0390I003(Y.Higuchi), T.Seo, T.Miyanishi, Y.Kawasaki, M.Suzuki, T.Sumiyoshi: Mismatch negativity and P3a/reorienting
complex in subjects with schizophrenia or at-risk mental state, 9th International Conference on Early Psychosis,(Tokyo, '14.11)，Early Intervention in Psychiatry, 8:137, 2014.

0390I004

Y.Kawasaki, R.Hashimoto, S.Ono, T.Shimada, H.Kihara, Y.Matsuda, M.Tunoda: Clinical activity of early detection
and intervention for young people at risk for developing psychosis in Uchinada, WASP2014 Jubilee Congress,(London, '14.11).

0390I005

Y.Kawasaki, R.Hashimoto, S.Takemoto, T.Shimada, H.Kihara, Y.Matsuda, M.Tunoda: Clinical service for young
people at risk for developing psychosis in Uchinada, 9ｔｈ International Conference on Early Psychosis, (Tokyo,'14.12)，Early Intervention in psychiatry, 8:119, 2014.

－ 56 －

0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging、Radiation therapy

Professor

WATANABE Naoto

Nuclear Medicine

KUGINUKI Yasuaki

Medical Radiography

OTA Kiyotaka

Radiation Therapy，Nuclear Medicine

Associate
Professor(Additional Post)
Assistant
Professor(Additional Post)
Assistant Professor

KITADATE Masataka Interventional Radiology, Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Assistant
Professor(Additional Post)

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

TSUCHIYA Naoko

Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Books
0400A001

Y.Masaki, N.Kurose, H.Tonami, H.Umehara: Other organs(central nervous system,prostate), IgG4-RelatedDisease(H.Umehara, K.Okazaki, JH.Stone, S.Kawa, M.Kawano), 113-117, Springer Japan, Tokyo, 2014.

Publications
Originals
0400B001

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, Y.Kuginuki, T.Miwa, H.Tonami: Fractional change in apparent diffusion
coefficient as an imaging biomarker for predicting treatment response in head and neck cancer treated withchemoradiotherapy, AJNR Am J Neuroradiol., 35:379-385, 2014.

－ 57 －

0400B002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, M.Taniguchi, H.Tonami, Y.Ueda,
T.Sakuma: Relationships between EGFR mutation status of lung cancer and preoperative factors-are they
predictive?, Asian Pac. J. Cancer Prev., 15:657-662, 2014.

0400B003

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, Y.Kuginuki, M.Taniguchi,
H.Tonami, Y.Ueda, T.Sakuma: Diagnostic performance of diffusion weighted imaging of malignant and benign
pulmonary nodules and masses: comparison with positron emission tomography, Asian Pac. J. Cancer Prev.,
15:4629-4635, 2014.

0400B004

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, H.Tonami, Y.Ueda,
T.Sakuma: Recurrence and metastasis of lung cancer demonstrate decreased diffusion on diffusion-weighted
magnetic resonance imaging, Asian Pac. J. Cancer Prev., 15:6843-6848, 2014.

0400B005

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, N.Watanabe, H.Tonami: Ability of diffusion-weighted MRI and 18FFDG-PET/CT as predictors of clinical outcome in chemoradiotherapy for head-and-neck cancer, Jpn. j. clin.
Radiol., 59:720-727, 2014 (in Japanese) .

Case Reports
0400D001

M.Doai, H.Tonami, N.Tsuchiya, T.Akai, N.Kurose, K.Hirata: 1H-MR spectroscopy in a case of isolated
intracranial rosai-dorfman disease, J Neurol Sci Turk, 31:790-795, 2014.

Presentations at Conference
International Conference (Presentations)
0400I001

M.Matoba, K.Ota, T.Kondo, M.Kitadate, T.Takahashi, N.Watanabe, H.Tonami: Utility of Changes in 18F-FDG
Uptake as a Prognostic Factor after Chemoradiotherapy in Head and Neck Squamous Cell Carcinoma Comparedwith Changes in Tumor Size, Asia-Pacific Congress of Cardiovascular and Interventional Radiology, (Shingapore,'14.05).

0400I002

M.Kitadate, H.Tonami, T.Shibamoto: Hemodynamics of portal venules during anaphylactic shock : Experimental
study by means of hepatic venography, Asia-Pacific Congress of Cardiovascular and Interventional Radiology,(Shingapore, '14.05).

0400I003

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma: DiffusionWeighted manetic resonance lmaging(DWI)signal intensity and distribution represents the amount of cancer,
American Thoracic Society International Canference 2014, (SanDiego, '14.05).

0400I004

H.Nagata, M.Matoba, O.Yamashita, C.Masu, M.Sawano, M.Yamada, M.Kawashima, H.Tsuji, H.Tonami: Evaluationof metastatic cervical lymph nodes using adaptive 4D volume perfusion CT in patients with head and necksquamous cell carcinoma, Radiological Society of North America, (Chicago, '14.11).

－ 58 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

KAWAHIRA Yoichi

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Senior Assistant Professor

KOBATA Takashi

Vascular surgery

Senior Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Senior Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Assistant Professor

TANAKA Hirokazu

Cardiovascular surgery, Vascular surgery

Assistant Professor

TSUCHIYA Hirokazu Cardiovascular surgery, Vascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of patient-specific cardiac supporting net for dilated heart failure patients
3.Endovascular stent-grafting for aortic aneurysm

Publications
Originals
0410B001(Y.Kubota), S.Miyagawa, A.Fukushima, A.Saito, H.Watabe, T.Daimon, Y.Sakai, T.Akita, Y.Sawa: Impact of cardiac
support device combined with slow-release prostacyclin agonist in a canine ischemic cardiomyopathy model, J.
Thorac. Cardiovasc. Surg., Volume147,1081-7, 2014.

－ 59 －

0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Professor

USUDA Katsuo

Assistant Professor

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Facultythoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy－ 60 －

Publications
Originals
0415B001

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, T.Oikawa, M.Saito, K.Kojima, Y.Takahara,
S.Shinomiya, A.Yamaya, T.Sakuma: Assessment of bispectral index monitor during flexible bronchoscopy performed
under conscious sedation, The Journal of the Japan Society for Respiratory Endoscopy, 36:12-19, 2014.

0415B002(C.Endo), T.Hasumi, Y.Matsumura, N.Sato, H.Deguchi, H.Oizumi, M.Sagawa, T.Tsushima, S.Takahashi, J.Shibuya,
M.Hirose, T.Kondo: A Prospective study of surgical procedures for patients with oligometastatic non-small celllung cancer, Ann. Thorac. Surg., 98:258-264, 2014.

0415B003

H.Minato, N.Kurose, M.Fukushima, T.Nojima, K.Usuda, M.Sagawa, T.Sakuma, A.Ooi, I.Matsumoto, M.Oda,
Y.Arano, J.Shimizu: Comparative immunohistochemical analysis of IMP3, GLUT1, EMA, CD146, and desmin for
distinguishing malignant mesothelioma from reactive mesothelial cells, Am. J. Clin. Pathol., 141:85-93, 2014.

0415B004

M.Tanaka, M.Sagawa, K.Usuda, Y.Machida, M.Uena, N.Motono, T.Sakuma: Postoperative drainage with one chest
tube is appropriate for pulmonary lobectomy: a randomized trial, Tohoku J. Exp. Med., 232:55-61, 2014.

0415B005

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, M.Taniguchi, H.Tonami, Y.Ueda,
T.Sakuma: Relationships between EGFR mutation status of lung cancer and preoperative factors-are they
predictive?, Asian Pac. J. Cancer Prev., 15:657-662, 2014.

0415B006

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, Y.Kuginuki, M.Taniguchi,
H.Tonami, Y.Ueda, T.Sakuma: Diagnostic performance of diffusion weighted imaging of malignant and benign
pulmonary nodules and masses: comparison with positron emission tomography, Asian Pac. J. Cancer Prev.,
15:4629-4635, 2014.

0415B007

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, H.Tonami, Y.Ueda,
T.Sakuma: Recurrence and metastasis of lung cancer demonstrate decreased diffusion on diffusion-weighted
magnetic resonance imaging, Asian Pac. J. Cancer Prev., 15:6843-6848, 2014.

0415B008

N.Motono, M.Ueno, M.Tanaka, Y.Machida, K.Usuda, T.Sakuma, M.Sagawa: Differences in the prognostic
significance of the SUV max between patients with resected pulmonary adenocarcinoma and squamous cell
carcinoma, Asian Pac. J. Cancer Prev., 15:10171-10174, 2014.

0415B009

M.Tanaka: Increased expression of receptor for advanced glycation end products in chronic obstructive pulmonary
disease, J. Kanazawa. Med. Univ., 39:18-25, 2014 (in Japanese) .

0415B010

M.Ueno: Expression of the receptor for advanced glycation end-products and its ligands in lung cancer, J.
Kanazawa. Med. Univ., 39:10-17, 2014 (in Japanese) .

0415B011(T.Kobayashi), Y.Kibe, T.Hiura, Y.Tanaka, K.Nishii, H.Kobayashi, I.Kanetsuki, A.Harada, T.Nagata, Y.Nakamura,
M.Satou, H.Nakayama, T.Akutsu, A.Sakurada, Y.Takeda, M.Sagawa: Evaluation of the exposed dose in alow dose
CT for lung cancer screening to its permitted image quality, The Journal of the Japanese Society of CT Screening,
21:68-73, 2014 (in Japanese) .

Reviews
0415C001

M.Sagawa, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda: Some issues need to be resolved for thedevelopment of a program for lung cancer screening using thoracic CT in Japan, The Journal of the JapaneseSociety of CT Screening, 21:96-100, 2014 (in Japanese) .

Case Reports
0415D001

M.Sagawa, T.Maeda, Y.Yutaka, T.Sakuma: Saline-cooled radiofrequency coagulation during thoracoscopic surgery
for giant bulla, Eur J Cardiothorac Surg, 46:737-739, 2014.

0415D002

Y.Machida, M.Tanaka, N.Motono, K.Usuda, M.Sagawa, T.Sakuma: A rare case of posterior dislocation of thesternum body caused during snowboarding, The Journal of the Japanese Association for Chest Surgery., 28:227229, 2014 (in Japanese) .

－ 61 －

Others
0415F001

T.Sakuma, MA.Matthay: Translational studies in the ex vivo human lung, Respir Investig., 52:219-220, 2014.

Presentations at Conference
International Conference (Presentations)
0415I001

Y.Machida, N.Motono, M.Tanaka, M.Ueno, K.Usuda, M.Sagawa: Global histon H3 lysine 4(H3K4)dimethylation is
an important prognostic factor in lung adenocarcinoma, American Thoracic Society International Canference 2014,(SanDiego, '14.05).

0415I002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, Y.Ueda, T.Sakuma: DiffusionWeighted manetic resonance lmaging(DWI)signal intensity and distribution represents the amount of cancer,
American Thoracic Society International Canference 2014, (SanDiego, '14.05).

0415I003

M.Tanaka, Y.Ueda, M.Shimasaki, M.Ueno, Y.Machida, N.Motono, K.Usuda, M.Sagawa, T.Sakuma: Increased
expression of receptor for advanced glycation end products in COPD, ERS Annual Congress 2014, (Munich,'14.09).

－ 62 －

0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUJITA Hideto

Surgical treatment of gastric cancer,

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

MORIOKA Emi

Surgery of Digestive Diseases

Assistant Professor

Surgery of Digestive Diseases

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Publications
Originals
0420B001

H.Funaki, S.Miura, E.Morioka, D.Kaida, T.Onishi, Y.Ohno, Y.Tomita, M.Noguchi, H.Fujita, S.Kinami, Y.Nakano,N.Ueda, T.Kosaka: Evaluation of combination chemotherapy with docetaxel and nedaplatin in patients withadvanced or recurrent esophageal cancer, Cancer & chemotherapy, 41:2384-2386, 2014 (in Japanese) .

－ 63 －

Case Reports
0420D001

T.Onishi, N.Ueda, T.Kosaka, S.Nakata, H.Minato: A case of intraductal papillary neoplasm of the bile duct (IPNB)
that underwent curative resection after follow-up of 1 year 4 months without treatment, 胆道, 28:81-88, 2014 (inJapanese) .

0420D002

N.Ueda, D.Kaida, Y.Tomita, T.Onishi, H.Funaki, H.Fujita, S.Kinami, Y.Nakano, T.Kosaka: A patient with invasive
carcinoma derived from IPMN who achieved long-term survival despite lymph node metastasis, Cancer &chemotherapy, 41:2202-2204, 2014 (in Japanese) .

Short Communications
0420E001

K.Matsunaga, R.Hayashi, T.Otsuka, D.Kaida, N.Ueda, T.Kosaka, T.Arisawa: A case of IgG4-related disease
complicated by duodenal bulbitis with IgG4-positive plasma cell infiltration, Endoscopy, 46:E408-E410, 2014.

Others
0420F001

S.Kinami, T.Onishi, J.Fujita, E.Morioka, D.Kaida, Y.Tomita, M.Noguchi, H.Funaki, H.Fujita, N.Ueda, Y.Nakano,
T.Koosaka, T.Fujimura, T.Ohta: Analysis of patterns of lymphatic flow in gastric cancer located in the upper third
region of the stomach for avoiding proximal gastrectomy, Japanese reserch society of clinical anatomy, 14:56-57,
2014 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0420H001

Y.Tomita, S.Miura, J.Fujita, E.Morioka, D.Kaida, T.Onishi, Y.Ono, M.Noguchi, H.Funaki, H.Fujita, S.Kinami,
Y.Nakano, N.Ueda, T.Kosaka, A.Asaka, T.Doumoto, T.Minamoto: Expression and clinical relevance of CRD-BP incolorectal cancer, The 25th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis,The
8th Internationla Conference of the International society of Gastroentrological Carcinogenesis, (Fukuoka, '14.11)，"The 25th Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis,The 8th Internationla
Conference of the International society of Gastroentrological Carcinogenesis Program&Abstracts".

International Conference (Presentations)
0420I001

T.Kosaka, J.Fujita, Y.Tomita, T.Onishi, S.Kinami: A Conversuin Gastrectomy for Patients with Initially
Unresectable Stage VI Gastric Cancer Provides Survival Benefit., 11th International Conference of the Asian
Clinical Oncology Society, (Taipei, '14.05).

0420I002

S.Kinami, T.Onishi, J.Fujita, D.Kaida, Y.Tomita, H.Funaki, H.Fujita, N.Ueda, Y.Nakano, T.Kosaka, S.Fushida,
T.Fujimura, T.Ohta: The ICG Fluorescence Sentinel Node Mapping for Gastric Cancer - Comparison with
Combination Mapping, 11th International Conference of the Asian Clinical Oncology Society, (Taipei, '14.05).

0420I003

J.Fujita, S.Kinami, E.Morioka, D.Kaida, Y.Ono, T.Onishi, Y.Tomita, H.Funaki, H.Fujita, Y.Nakano, N.Ueda,
T.Kosaka: The Survivall Prognosis of the Patients Over 85 Years Old Who Were Suffered from the
Gastroenterological Carcinoma and Had the Surgical Resection., 11th International Conference of the Asian
Clinical Oncology Society, (Taipei, '14.05).

0420I004

Y.Tomita, S.Kinami, S.Miura, J.Fujita, E.Morioka, D.Kaida, T.Onishi, Y.Ono, M.Noguchi, H.Funaki, H.Fujita,
Y.Nakano, N.Ueda, T.Kosaka, T.Minamoto: The Expression and the Clinical Role of the CRD-BP, theTranscriptional Target of the β-Catemin in the Wnt Signaling Pathway, in the Colorectal Cancer, 11th
International Conference of the Asian Clinical Oncology Society, (Taipei, '14.05).

0420I005

T.Shimasaki, N.Ueda, N.Kawada, T.Nomura, K.Yamada, H.Yamada, R.Hayashi, K.Matsunaga, T.Fukuyama,
T.Otsuka, M.Nakamura, N.Toshikuni, H.Shiroeda, T.Kosaka, N.Tomosugi, T.Minamoto, T.Arisawa: Phase i clinical
trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistantadvanced pancreatic cancer patients, Didestive Disease Week 2014, (Chicago, '14.05).

－ 64 －

0420I006

M.Noguchi, A.Motoyoshi, M.Earashi, H.Fujii: Long-term results of small breast cancer patients treated withradiofrequency ablation and mammotome excision, 18th SIS World Congress on Breast Healthcare, (Orlando,'14.10).

0420I007

M.Noguchi, M.Noguchi, Y.Ono, E.Morioka, S.Miura, Y.Nakano, T.Kosaka, N.Kurose, H.Minato: Feasibility studyof axillary reverse mapping for patients with clinically node-negative breast cancer, 18th SIS World Congress on
Breast Healthcare, (Orlando, '14.10).

0420I008

S.Kinami, T.Onishi, H.Fujita, N.Ueda, Y.Nakano, T.Kosaka, S.Fushida, T.Fujimura, T.Ohta: Establishing
lymphatic compartments of the stomach: a sentinel node mapping-derived clinical grouping of the regional lymph
nodes of the stomach, Asian Joint Congress of Clinical Anatomy. 2nd Congress of Asian Association of ClinicalAnatomy. 18th Congress of Japanese Research Society of Clinical Anatomy, (Tokyo, '14.11)，Asian Joint Congressof Clinical Anatomy. 2nd Congress of Asian Association of Clinical Anatomy. 18th Congress of Japanese ResearchSociety of Clinical Anatomy Program & Abstracts, 88, 2014.

－ 65 －

0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Professor

KAWAHARA Norio

Spinal surgery

Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Associate Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Associate Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Senior Assistant Professor

FUKUI Kiyokazu

Hip surgery

Senior Assistant Professor

HIROMURA Kentaro

TraumaSenior Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

ORITA Yugo

orthopaedic surgery

Assistant Professor

TAKAHASHI Eiji

Hip surgery

Assistant Professor

TAGUCHI Keita

orthopaedic surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Assistant Professor

NAKAGAWA Shintaro Hip surgery

Assistant Professor

HATANO Eijyu

Spinal surgery

Assistant Professor

MIKAMI Tomoaki

Hip surgery

Assistant Professor

YASUDA Yoshihito

Spinal surgery

Research Doctor

KANEKO Seiji

Hip surgery

Research Doctor

SOMA Daisuke

orthopaedic surgery

Research Doctor

MIYAUCHI Yukitaka

orthopaedic surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, spinal cord injury

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal
cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4
is a digestive enzyme of CSPG . In future, we will clarify the mechanism.

－ 66 －

Books
0430A005

N.Kawahara, K.Tomita, M.Kawaguchi, H.Murakami, T.Matsumoto, H.Tsuchiya: Management of spinal metastasis,
Current Progress in Orthopedics 1 (A.Johari, KD.Luk, JP. Waddell, eds), 175-186, TreeLife Media, INDIA, 2014.

Publications
Originals
0430B001(CG.Fisher), R.Schouten, AL.Versteeg, S.Boriani, PP.Varga, LD.Rhines, N.Kawahara, D.Fourney, L.Weir,
JJ.Reynolds, A.Sahgal, MG.Fehlings, ZL.Gokaslan: Reliability of the spinal instability neoplastic score (SINS)
among radiation oncologists: an assessment of instability secondary to spinal metastases, Radiat Oncol., 9:69;1-7,
2014.

0430B002(S.Kato), H.Murakami, S.Demura, K.Yoshioka, N.Kawahara, K.Tomita, H.Tsuchiya: More than 10-year follow-up
after total en bloc spondylectomy for spinal tumors, Ann. Surg. Oncol., 21:1330-1336, 2014.

0430B003

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Retrieval analysis of new-generation yttria-stabilized
zirconia femoral heads after total hip arthroplasty, Eur J Orthop Surg Traumatol., 24:1197-1202, 2014.

0430B004(CG.Fisher), AL.Versteeg, R.Schouten, S.Boriani, PP.Varga, LD.Rhines, MK.Heran, N.Kawahara, D.Fourney,
JJ.Reynolds, MG.Fehlings, ZL.Gokaslan: Reliability of the spinal instability neoplastic scale among radiologists: anassessment of instability secondary to spinal metastases., AJR Am. J. Roentgenol., 203:869-874, 2014.

0430B005

K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto: Inversion of the acetabular labrum triggers rapidly destructive
osteoarthritis of the hip: Representative case report and proposed etiology, J. Arthroplasty., 29:2468-2472, 2014.

0430B008(T.Hato), J.Kamogawa, N.Kawahara: 3-D MRI/CT fusion imaging for PLIF, J Spine Res., 5:1366-1370, 2014 (inJapanese) .

0430B010(K.Shintani), Y.Adachi, A.Kaneuji, S.Oshima: Study on wear characteristics of artificial hip joint using a 3D typewear simulator, Japanese Journal of Clinical Biomechanics., 35:211-217, 2014 (in Japanese) .

Case Reports
0430D001

K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto: Imaging and histopathological evaluation of a cystlike formationin subchondral insufficiency fracture of the femoral head: a case report and literature review., Int J Surg Case Rep.,
5:324-329, 2014.

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

N.Kawahara: Long term FU of TER in Renal Cell Carcinoma Metastasis, 3rd Bologna-Budapest Spine Meeting on
Tumor and Osteoporosis, (Budapest, '14.11).

International Conference (Synposium)
0430H001

N.Kawahara: Surgical planning versus surgery : Lumbosacral junction, AOSpine Masters Symposium—SurgicalTreatment of Spine Tumors, (Budapest, '14.11).

International Conference (Presentations)
0430I001

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto: Minimum ten-year results of a cementless
anatomic total hip femoral component with cirumferential porous coating for hips with developmental, Orthopedics
today Hawaii 2014, (Maui, '14.01).

－ 67 －

0430I002

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, S.Ueda, R.Tsuda, T.Matsumoto: Joint preservation rate
at 25 years after rotational acetabular osteotomy for development hip dysplasia, American Academy of Orthopaedic
Surgeons (AAOS) 2014 Annual Meeting, (New Orleans, '14.03).

0430I003

S.Ueda, T.Ichiseki, A.Kaneuji, S.Kaneko, T.Matsumoto: Oxdative stress induced hypoxia in rat model, 17th
Biennial Meeting of Society for Free Radical Research International (SFRRI 2014), (Kyoto, '14.03).

0430I004

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocyte in a rat spinal cord hemisection model, CSRS AP5 Viet Nam 2014, (Ho Chi Minh, '14.04).

0430I005

T.Sugimori, Y.Tachi, R.Tsuda, A.Kaneuji, T.Matsumoto: Elastic modulus measurement of posterior cruciate
ligament in cruciate-retaining total knee arthroplasty, 2014 ICJR Pan Pacific Congress, (Kona, '14.07)，"JISRF
Reconstructive Review, 4(Sup.1)", 440, 2014.

0430I006

K.Fukui, KK.Briggs, CA.Trindade, MJ.Phillppon: Two-year results of arthroscopic treatment using modern
technique in the borderline dysplastic hip patients, International Society for Hip Arthroscopy Annual Scientific
Meeting 2014 (ISHA 2014), (Rio de Janeiro, '14.10).

0430I007(CA.Trindade), KK.Briggs, K.Fukui, MJ.Phillppon: Relationship between the faber distance test and theradiographic alpha-angle in patients with FAI, International Society for Hip Arthroscopy Annual Scientific Meeting2014 (ISHA 2014), (Rio de Janeiro, '14.10).

0430I008(CA.Trindade), G.Sawyew, KK.Briggs, K.Fukui, MJ.Phillppon: Arthroscopic reconstruction of the hip capsule:
surgical technique, International Society for Hip Arthroscopy Annual Scientific Meeting 2014 (ISHA 2014), (Rio deJaneiro, '14.10).

0430I009

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocytes in a rat spinal cord hemisection model, Neuroscience 2014, (Washington,DC, '14.11).

－ 68 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Professor

TAKADA Hisashi

cerebrovascular disease

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

SASAGAWA Yasuo

brain tumor

Assistant Professor

SIRAGA Syunsuke

cerebrovascular disease

Research Doctor

TSUKADA Tsuyoshi

general neurosurgery，neuroembryology

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis－ 69 －

Publications
Originals
0440B001

Y.Sasagawa, T.Akai, S.Nakada, H.Minato, O.Tachibana, T.Nojima, H.Iizuka: Narrow band imaging-guided
endoscopic biopsy for intraventricular and paraventricular brain tumors:clinical experience with 14 cases, Acta
Neurochir (Wien), 156:681-687, 2014.

Case Reports
0440D001(H.Hashimoto), A.Maeda, K.Kumano, T.Kimoto, Y.Fujisawa, T.Akai: Rapid deterioration of primary fourth
ventricular outlet obstruction resulting in syndrome of inappropriate antidiuretic hormone secretion, Pediatr. Int.,56:e30-e32, 2014.

0440D002

M.Doai, H.Tonami, N.Tsuchiya, T.Akai, N.Kurose, K.Hirata: 1H-MR spectroscopy in a case of isolated
intracranial rosai-dorfman disease, J Neurol Sci Turk, 31:790-795, 2014.

Presentations at Conference
International Conference (Presentations)
0440I001

Y.Sasagawa, T.Akai, O.Tachibana, H.Iizuka: Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse
large B-cell lymphoma of the central nervous system, The 15th European congress of Neurosurgery Annual
Meeting, (Prague, '14.10).

－ 70 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Plastic and Reconstructive Surgery

Assistant Professor

KAMIMURA Yuri

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

TAGUCHI Hisao

Plastic and Reconstructive Surgery

Assistant Professor

DOI Yujin

Plastic and Reconstructive Surgery

Assistant Professor

YAMASHITA Akiko

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

YAGISHITA Mikio

Plastic and Reconstructive Surgery

Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

－ 71 －

Publications
Originals
0450B001

M.Yamashita, H.Daizo, K.Shimada: Three-dimensional computed tomography venography as a guide for
cranioplasty in parietal cephalocele, J. Craniofac. Surg., 25:224-225, 2014.

0450B002

M.Yamashita, A.Nishio, H.Daizo, M.Kishibe, K.Shimada: Repair of orbital fracture:the antral balloon withimplantable reservoir technique, J. Craniofac. Surg., 25:554-556, 2014.

0450B003

M.Yamashita, M.Kishibe, K.Shimada: Incidence of lower eyelid complications after a transconjunctival approach:
influence of repeated incisions., J. Craniofac. Surg., 25:1183-1186, 2014.

0450B004

A.Nishio, M.Yamashita, K.Shimada: The surgical indication for linear orbital floor fractures, 日頭顎顔会誌, 30:2735, 2014 (in Japanese) .

Case Reports
0450D001

M.Yamashita, A.Nishio, H.Daizo, M.Kishibe, K.Shimada: Intraoperative acquired pressure ulcer on lower lip: acomplication of rhinoplasty, J. Craniofac. Surg., 25:e3-e4, 2014.

0450D002

A.Komuro, Y.Doi, K.Shimada: A Case of heat press injury of the foot caused by a plastic extruding machine,
Japanese journal of burn injuries., 40:51-58, 2014 (in Japanese) .

0450D003

I.Chikazawa, D.Nakai, M.Morita, H.Tachibana, T.Tanaka, K.Miyazawa, M.Kishibe, Y.Kamimura, E.Kinoshita,
N.Kurose: Skin and lung metastasis from renal cell carcinoma 23 years after radical nephrectomy-a case report-,
Jpn. J. Cancer Clin., 60:537-542, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0450I001

S.Kawakami, M.Yamashita: Aesthetic Osteotomy for Jaw Deformity, Aesthetic Plastic Surgery 2014, (Korea,'14.04).

0450I002

K.Shimada, M.Kishibe, S.Kawakami: Clinical experience of NPWT (VAC and RENASYS) in our department:Tips
and ideas for its use with artificial dermis, The 12th Korea-Japan Congress of Plastic and Reconstructive Surgery,(Korea, '14.05).

0450I003

M.Yamashita, S.Kawakami: Role of spreader grafts in open septorhinoplasty, The 12th Korea-Japan Congress of
Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I004

H.Daizo, K.Shimada, M.Kishibe, S.Kawakami: Investigation into the symmetrical outcome of two primary breastreconstruction methods, The 12th Korea-Japan Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I005

Y.Kamimura, T.Miyanaga, S.Kawakami: Maggot debridement therapy for the wound bed preparation of chronic
ulcers treatment, The 12th Korea-Japan Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I006

M.Kishibe, K.Shimada, S.Kawakami: The problem and limit of treatment for frontalis muscle palsy, The 12th
Korea-Japan Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I007

K.Sugishita, A.Nishio, M.Kishibe, S.Kawakami: Treatment with platelet-rich plasma (PRP) for chronic skin ulcers,
The 12th Korea-Japan Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I008

A.Nishio, M.Yamashita, R.Taguchi, K.Shimada, S.Kawakami: Pediatric orbital floor fracture, The 12th Korea-Japan
Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

－ 72 －

0450I009

T.Miyanaga, K.Shimada, M.Kishibe, H.Daizo, A.Komuro, S.Kawakami: Reconstruction of syndactyly with bony
attachments in Apert syndrome using perifascial areolar tissue (PAT) graft, The 12th Korea-Japan Congress of
Plastic and Reconstructive Surgery, (Korea, '14.05).

0450I010

Y.Ikawa, H.Daizo, S.Kawakami: Deep vein thrombosis and pulmonary thromboembolism in burn patients, The 12th
Korea-Japan Congress of Plastic and Reconstructive Surgery, (Korea, '14.05).

－ 73 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Assistant Professor

OSHIKIRI Takahiro

Pediatric surgery

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Faculty

Assistant Professor
Research Doctor

TAKAHASHI
Sadayoshi
SHIRONOMAE
Tsubasa

Pediatric surgery
Pediatric surgery

Research Doctor

NISHIDA Shoichi

Pediatric surgery

Research Doctor

FUKUNAGA Kenji

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

Y.Yasui, M.Kohno, T.Shironomae, T.Kuwahara, D.Takahashi, T.Oshikiri: Anal canal plastic surgery for fecal
incontinence after transanal endorectal pull-through for hirschsprung disease, Journal of the Japanese Society ofPediatric Surgery., 50:1022-1028, 2014 (in Japanese) .

Case Reports
0460D004

T.Kuwahara, S.Nishida, K.Fukunaga, S.Takahashi, T.Oshikiri, M.Kohno: Thyroglossal duct cyst in the base of the
tongue, Japanese journal of pediatric surgery ; Shoni geka., 46:1201-1204, 2014 (in Japanese) .

0460D005

H.Fukumotol, M.Kohno, T.Kuwahara, S.Takahashi, T.Oshikiri, Y.Yasui: Case of congenital chylous ascites inwhich lymphatic scintigraphy was effective for determining the course of treatment, Journal of the Japanese Societyof Pediatric Surgery., 50:1119-1122, 2014 (in Japanese) .

－ 74 －

Presentations at Conference
International Conference (Presentations)
0460I001

T.Miyazawa, T.Miwa, H.Tsuji, Y.Suzuka, M.Kohno, Y.Yasui: Laryngotracheal separation for type Ⅲ
Laryngotracheoesophageal cleft with congenital heart disease, The 31st Congress of the Pan-Pacific Surgical
Association Japan Chapter in Tapei, Taiwan, (Taipei, '14.10).

－ 75 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication
ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Professor

KITAGAWA Kazuko

Professor(Additional Post)

KOJIMA Masami

Associate Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

lacrimal fluid

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

SHIBATA Shinsuke

cataract, ophthalmology

Assistant Professor

OSADA Hiromi

cataract, ophthalmology

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics

Assistant Professor

TAKAHASHI Yorikocataract

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 76 －

Publications
Originals
0470B001(B.Chhunchha), N.Fatma, E.Kubo, DP.Singh: Aberrant sumoylation signaling evoked by reactive oxygen species
impairs protective function of Prdx6 by destabilization and repression of its transcription, FEBS J., 281:3357-3381,
2014.

0470B002

N.Mita, H.Sasaki, K.Kani, A.Tabuchi, H.Hara: Multiple comparisons for a psychophysical test in bootstrap logistic
regression, J Algorithm Comput Technol., 8:339-355, 2014.

0470B003(N.Hamada), Y.Fujimichi, T.Iwasaki, N.Fujii, M.Furuhashi, E.Kubo, T.Minamino, T.Nomura, H.Sato: Emerging
issues in radiogenic cataracts and cardiovascular disease, J. Radiat. Res., 55:831-846, 2014.

0470B004(K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki,
M.Taki, Y.Kamimura, A.Hirata, H.Shirai: Dosimetry using a localized exposure system in the Millimeter-Waveband for in vivo studies on ocular effects, IEEE Trans. Microw. Theory Tech., 62:1554-1564, 2014.

0470B005

A.Arimoto, K.Kitagawa, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki: Effect of rebamipide ophthalmic suspension on
signs and symptoms of keratoconjunctivitis sicca in sjogren syndrome patients with or without punctal occlusions,
Cornea, 33:806-811, 2014.

0470B006(T.Tokutake), T.Yamauchi, N.Mita, Ken-ichiro Kawamoto, H.Tabuchi, K.Kani, H.Hara, A.Tabuchi, H.Sasaki:
Pepeatability of visua acuity testing using a psychometric function, Jpn. J. Ophthalmol., 58:381-387, 2014.

0470B007

N.Hatsusaka, K.Sasaki, Y.Kawakami, M.Sasaki, H.Sasaki: Evaluation of casey eye Institute camera forphotographic documentation of opaque crystalline lens, Japanese journal of clinical ophthalmology Rinsho ganka.,
68:1413-1420, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0470I001

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosi: Its relationship to posterior capsule
opacity, International Conference on the Lens, (Hawaii, '14.01).

0470I002

H.Sasaki, N.Hatsusaka, N.Shibata, S.Shibata, Y.Kurihara, CY.Tsai, E.Kubo: Comparison of ocular UV exposure byfacial contour, International Conference on the Lens, (Hawaii, '14.01).

0470I003

N.Hatsusaka, N.Shibata, S.Shibata, N.Fujita, H.Osada, E.Kubo, H.Sasaki: Correlation of UV eposure dose between
top of head and eye, International Conference on the Lens, (Hawaii, '14.01).

0470I004

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki: Lens damage
induced by 40 GHz millimeter wave, International Conference on the Lens, (Hawaii, '14.01).

0470I005

T.Shibata, S.Shibata, E.Kiyokawa, H.Sasaki, E.Kubo: Tropomyosi: Inhibition of progression of sugar cataract ingalactose-fed rats and induction of anti-oxidant protein, Peroxiredoxin 6, International Conference on the Lens,(Hawaii, '14.01).

0470I006(P.Steinkamp), K.Sasaki, N.Hatsusaka, F.Fraunfelder, H.Sasaki: Correlating retroillumination images of lens
opacity subtype with the change in vision, World Ophthalmology Congress of the International Council ofOphthalmology, (Tokyo, '14.04).

0470I007

N.Mita, H.Osada, N.Shibata, E.Kubo, H.Sasaki: Influential factors in transparent crystalline lens accommodation,
World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

0470I008

A.Okamoto, M.Sasaki, Y.Takahashi, E.Kubo, H.Sasaki: Correlation between axial length and visual function of eyewith aspheric IOL, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

－ 77 －

0470I009

E.Shibuya, M.Takahashi, M.Sasaki, A.Okamoto, H.Sasaki: Pupil diameter size and visual funtion in eyes withmultifocal intraocular lens, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo,'14.04).

0470I010

M.Takahashi, H.Osada, S.Enta, M.Sasaki, H.Sasaki: Correlation between visual acuity and contrast acuity by typeof lens opacity, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

0470I011(M.Tamura), N.Hatsusaka, Y.Sakamoto, HM.Cheng, H.Sasaki: Regional differences infactors for ocular refraction
related to myopia progression among teenagers linving in east asia, World Ophthalmology Congress of theInternational Council of Ophthalmology, (Tokyo, '14.04).

0470I012

N.Hatsusaka, Y.Sakamoto, K.Sasaki, E.Kubo, H.Sasaki: 10 years change in corneal astignatism with aging, World
Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

0470I013

M.Fukuda, S.Shibata, H.Osada, E.Kubo, H.Sasaki: Delayed corneal wound healing resulting from theadministration of fluoroquinolone antibacterial ophthalmic solutions and its causes, World Ophthalmology Congressof the International Council of Ophthalmology, (Tokyo, '14.04).

0470I014

H.Sasaki, N.Hatsusaka, N.Fujita, S.Shibata, E.Kubo: Relationship between UV index and ocular UV-B exposure,World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

0470I015

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosin regulation of stress fiber formationand EMT in lens epithelial cells, Association for Research in Vision and Ophthalmology, (Orlando, '14.05).

0470I016

S.Shibata, DP.Singh, N.Shibata, H.Sasaki, E.Kubo: Hyperglycemia- and oxidative stress-induced hyperoxidation of
Prdx 6 during lens epithelial cell damage and rat lens opacity in vitro and in vivo, Association for Research in
Vision and Ophthalmology, (Orlando, '14.05).

0470I017

N.Shibata, K.Sasaki, N.Yamanaka, N.Hatsusaka, H.Sasaki: Applicability of detecting auto fluorescence as early
sign of pinguecula, Association for Research in Vision and Ophthalmology, (Orlando, '14.05).

0470I018

H.Sasaki, N.Hatsusaka, N.Shibata, S.Shibata, Y.Kurihara, CY.Tsai, E.Kubo: Influence of difference between asian
and western facial contours on ocular UV exposure, Association for Research in Vision and Ophthalmology,(Orlando, '14.05).

0470I019(J.Chakarothai), M.Kojima, Kensuke Sasaki, K.Wake, Y.Suzuki, M.Taki, S.Watanabe: Millimeter-wave power
absorbed into rabbit eye due to different exposure environments, EMC2014, (Tokyo, '14.05).

0470I020

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, M.Taki, K.Sasaki,
H.Sasaki: Millimeter wave exposure induces cornea and lens epithelium damage, BioEM2014, (Cape Town, '14.06).

0470I021

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: 75 GHz millimeter wave exposure to eye: role of environment factors in effects, BioEM2014, (CapeTown, '14.06).

0470I022

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Effect of relative Humidity during 40 GHz millimeter wave exposure, 31th URSI General Assembly and
Scientific Symposium, (Beijing, '14.08).

0470I023

H.Sasaki, N.Hatsusaka, M.Takahashi, N.Shibata, Y.Takahashi, K.Sasaki, E.Kubo: 10 years change in refractive
power of crystalline lens and relationship with opacification type in eyes with water clefts, XXXII Congress of the
ESCRS, (Londonn, '14.09).

0470I024

M.Kojima, CY.Tsai, T.Okuno, K.Sasaki, K.Sasaki, H.Sasaki: Ocular temperature measurements during infrared or
millieter wave exposure, 39th International Conference on Infrared, Millimeter, and THz Waves, (Tucson, '14.09).

0470I025

E.Kubo: Risk and benefit of suppement for vision and eye health, 13th Congress of the International Society ofOcular Toxicology, (Kanazawa, '14.10).

0470I026

H.Sasaki, N.Mita, N.Hatsusaka, M.Takahashi, E.Shibuya, M.Sasaki, S.Enta, Y.Takahashi, T.Shibata, K.Sasaki,
E.Kubo: Visual function of eyes by five types of lens opacities, 13th Congress of the International Society ofOcular Toxicology, (Kanazawa, '14.10).

－ 78 －

0470I027

H.Osada, N.Hatsusaka, E.Shibuya, M.Sasaki, M.Takahashi, A.Nakano, E.Kubo, T.Abe, K.Tsubota, H.Sasaki:
Data-analysis pre-study of initial lenticular findings in emergency workers at Tokyo Electric Power Fukushima
Nuclear Power Plant, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I028

K.Kitagawa, N.Shibata, Y.Takahashi, K.Hagiwara, H.Sasaki: Adverse effects of topical anti-glaucomatous agents inpatients with severe dry eye, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I029

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Sasaki, H.Sasaki: Effects of environmental factors during
millimeter wave exposure, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I030

M.Kojima, CY.Tsai, Y.Suzuki, T.Okuno, Kensuke Sasaki, K.Sasaki, H.Sasaki: Ocular temperature measurements
during electromagnetic exposure, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa,'14.10).

0470I031

M.Fukuda, K.Sasaki, H.Sasaki: Cytotoxic effects of 4 OTC ophthalmic solutions on cultured rabbit corneal cellline, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I032

A.Arimoto, K.Nagai, R.Honda, H.Osada, S.Shibata, T.Shibata, E.Kubo, H.Sasaki: Lens pathological change after
intravitreal injection of bevacizumab, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa,'14.10).

0470I033

S.Shibata, K.Kitagawa, T.Shibata, N.Shibata, K.Hagihara, H.Sasaki: Eye disorders associated with colored contactlenses: 3 case studies, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I034

N.Hatsusaka, H.Sasaki: Measurement of ocular UV exposure with mannequin UV sensors, 13th Congress of theInternational Society of Ocular Toxicology, (Kanazawa, '14.10).

0470I035

N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, S.Enta, Y.Takahashi, T.Shibata, K.Sasaki, E.Kubo, H.Sasaki: Visualfunction of cataract sub-types, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa,'14.10).

0470I036

N.Shibata, K.Sasaki, N.Hatsusaka, N.Yamanaka, H.Sasaki: Auto-fluorescence is an early sign of developing
pinguecula, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

－ 79 －

0475

Department of Otorhinolaryngology

Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Associate Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology

Senior Assistant Professor

TERAGUCHI Kanako Rhinology, generel otology

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

NODA Takuya

General otorhinolaryngology

Assistant Professor

YAMADA Kentaro

General otorhinolaryngology

Faculty

Keywords of Researcholfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep
apnea & snoar surgery

Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Yamada K, Yamamoto, Yamada K, Noda, Harita)
New educational system for endoscopic sinus surgery(Miwa , Shiga, Yamada K)
Auditory central functional imaging with MEG(Suzuka, Yamada K)
Clinical research for snoar and sleep apnea(Miwa, Sakai)

Publications
Originals
0475B001

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, Y.Kuginuki, T.Miwa, H.Tonami: Fractional change in apparent diffusion
coefficient as an imaging biomarker for predicting treatment response in head and neck cancer treated withchemoradiotherapy, AJNR Am J Neuroradiol., 35:379-385, 2014.

0475B002(S.Kawabata), CT.Chiang, J.Tsurutani, H.Shiga, ML.Arwood, T.Komiya, JJ.Gills, RM.Memmott, PA.Dennis:
Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lungcancer., Oncotarget., 5:1062-1070., 2014.

0475B003

H.Shiga, M.Nagaoka, K.Washiyama, J.Yamamoto, K.Yamada, T.Noda, M.Harita, R.Amano, T.Miwa: Reduced nasal
transport of insulin-like growth factor-1 to the mouse cerebrum with olfactory bulb resection., Chem. Senses,
39:595-599, 2014.

0475B004

H.Shiga, J.Yamamoto, M.Kitamura, H.Nakagawa, T.Matsubasa, A.Seo, T.Miwa: Combinations of two odorants ofsmell identification test for screening of olfactory impairment., Auris Nasus Larynx, 41:523-527, 2014.

－ 80 －

0475B006

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

Reviews
0475C009

H.Shiga: Post-traumatic olfactory impairment, Journal of Japan Association on Odor Environment, 45:278-281,
2014 (in Japanese) .

0475C017

T.Miwa: Olfactory function test-present status and future prospects-, Pract. otol., 107:849-857, 2014 (inJapanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0475G001

Y.Suzuka: Development of Hearing Devices, The 31st Congress of the Pan-Pacific Surgical Association Japan
Chapter in Taipei, Taiwan, (Taipei, '14.10).

International Conference (Presentations)
0475I001

H.Shiga, M.Nagaoka, K.Washiyama, J.Yammoto, K.Yamada, T.Noda, M.Harita, R.Amano, T.Miwa: Olfactorytransport is necessary for nasally administered insulin-like growth factor-I to increase phosphorylation of
extracellular signal-regulated kinase 1/2 in the cerebrum of mice., The 36th annual meeting of the Association for
Chemoreception Sciences, (Bonita Springs, '14.04).

0475I002(M.Higuchi), Y.Suzuka, D.Oyama, G.Uehara: Comparison of EEG and MEG coherence functions between a brain
signal and a sound envelope in a selective listening study, 19th International Conference on Biomagnetism,(Halifax, '14.08).

0475I003

Y.Suzuka, M.Higuchi, D.Oyama, G.Uehara: An MEG study of the cocktail-party effect using the coherence funtion
between brain signal and a sound envelope, 19th International Conference on Biomagnetism, (Halifax, '14.08).

0475I004

H.Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, S.Kinuya, M.Furukawa, T.Miwa: Assessment of peripheral
olfactory nerve image in patients with idiopathic olfactory impairments in comparison to healthy volunteers.,
European Chemoreception Research Organization 2014, (Dijon, '14.09).

0475I005

T.Miwa, J.Yamamoto, K.Teraguchi, Y.Kinoshita, K.Yamada, T.Noda, M.Harita, H.Shiga, E.Sugiyama, K.Ono,
M.Kawai: Changes in smell and taste function in the elderly, European Chemoreception Research Organization
24th Congress, (Dijion, '14.09).

0475I006

M.Harita, K.Yamada, J.Yamamoto, K.Teraguchi, T.Miyazawa, H.Shiga, Y.Suzuka, T.Miwa: Outcomes of olfactory
function after endoscopic sinus surgery for eosinophilic chronic sinusitis, The 31st Congress of the Pan-PacificSurgical Association Japan Chapter in Taipei ,Taiwan, (Taipei, '14.10).

0475I007

T.Miyazawa, T.Miwa, H.Tsuji, Y.Suzuka, M.Kohno, Y.Yasui: Laryngotracheal separation for type Ⅲ
Laryngotracheoesophageal cleft with congenital heart disease, The 31st Congress of the Pan-Pacific Surgical
Association Japan Chapter in Tapei, Taiwan, (Taipei, '14.10).

0475I008

T.Miwa, J.Yamamoto, K.Teraguchi, Y.Kinoshita, K.Yamada, T.Noda, M.Harita, H.Shiga, E.Sugiyama, K.Ono,
M.Kawai: Changes in smell and taste function in the elderly, Clinical Chemosensation 2014, (Dresden, '14.11).

0475I009

M.Harita, K.Yamada, T.Noda, K.Teraguchi, H.Shiga, T.Miwa: Predictors of olfactory dysfunction in chronicrhinosinusitis, Clinical Chemosensation 2014, (Dresden, '14.11).

－ 81 －

0485

Department of Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

TSUTSUMIUCHI
Toshiki

General otorhinolaryngology

Keywords of Researchhead and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle
aspiration cytology, chemoradiotherapy

Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode)
New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government
cooperation (Tsuji, Shimode)
Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji,
Shimode)Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)

Publications
Originals
0485B001

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, Y.Kuginuki, T.Miwa, H.Tonami: Fractional change in apparent diffusion
coefficient as an imaging biomarker for predicting treatment response in head and neck cancer treated withchemoradiotherapy, AJNR Am J Neuroradiol., 35:379-385, 2014.

0485B002

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, N.Watanabe, H.Tonami: Ability of diffusion-weighted MRI and 18FFDG-PET/CT as predictors of clinical outcome in chemoradiotherapy for head-and-neck cancer, Jpn. j. clin.
Radiol., 59:720-727, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0485I001

T.Miyazawa, T.Miwa, H.Tsuji, Y.Suzuka, M.Kohno, Y.Yasui: Laryngotracheal separation for type Ⅲ
Laryngotracheoesophageal cleft with congenital heart disease, The 31st Congress of the Pan-Pacific Surgical
Association Japan Chapter in Tapei, Taiwan, (Taipei, '14.10).

0485I002

H.Nagata, M.Matoba, O.Yamashita, C.Masu, M.Sawano, M.Yamada, M.Kawashima, H.Tsuji, H.Tonami: Evaluationof metastatic cervical lymph nodes using adaptive 4D volume perfusion CT in patients with head and necksquamous cell carcinoma, Radiological Society of North America, (Chicago, '14.11).

－ 82 －

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Associate Professor

WATANABE Seiji

Medical mycology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

TAKEDA Kiminobu

Medical mycology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Assistant Professor

SHIMADA Toshitsugu Dermatology

Research Doctor

KITAYAMA Asuka

cutaneous malignant tumor

Research Doctor

KOJIMA Kiyoto

genetic diagnosis

Research Doctor

NANBU Masayuki

Dermatopathology

Research Doctor

HATTA Jyunko

Image analysis

Research Doctor

WATANABE Junko

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, langerhans cell

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

－ 83 －

Publications
Originals
0490B001(K.Yoshimura), N.Ishii, T.Hamada, T.Abe, F.Ono, K.Hashikawa, S.Fukuda, B.Ohyama, H.Koga, R.Sogame,
K.Teye, T.Ochiai, H.Nakajima, K.Nakajima, S.Iijima, M.Kanzaki, K.Kojima, T.Nagatani, W.Fujimoto, T.Karashima,
T.Nakama, C.Ohata, M.Furumura, D.Tsuruta, T.Hashimoto: Clinical and immunological profiles in 17 Japanesepatients with drug-induced pemphigus studied at Kurume University, Br. J. Dermatol., 171:544-553, 2014.

0490B002

T.Iwanaga, K.Anzawa, T.Mochizuki: Quantification of dermatophyte viability for evaluation of antifungal effect by
quantitative PCR, Mycopathologia, 177:241-249, 2014.

0490B003(R.Kano), E.Yoshida, T.Yaguchi, V.Hubka, K.Anzawa, T.Mochizuki, A.Hasegawa, H.Kamata: Mating type gene
(MAT1-2) of Trichophyton verrucosum, Mycopathologia, 177:87-90, 2014.

Case Reports
0490D004

K.Takeda, K.Anzawa, T.Mochizuki: A case of thermal burn on the extensor surface of forearm caused by asmartphone, The Japanese Journal of Dermatology, 124:1149-1151, 2014 (in Japanese) .

0490D005(A.Takeuchi), Y.Hamaguchi, M.Fujimoto, K.Takehara, K.Anzawa, T.Mochizuki: A case of deep cutaneous mycosis
by Scedosporium apiospremum in a pemphigus foliaceus patient under immunosuppressive condition, The Japanese
Journal of Dermatology, 124:1135-1140, 2014 (in Japanese) .

0490D006

M.Nanbu, K.Kojima, J.Hatta, K.Takeda, T.Fujii, H.Tanabe, T.Mochizuki: A case of erosive pustular dermatosis of
the scalp fairly well improved by topical application of corticosteroid, Skin research, 13:189-193, 2014 (inJapanese) .

0490D007(S.Urano), Y.Suzuki, K.Anzawa, T.Ohishi, S.Kuroishi, N.Itoh, T.Okada, T.Mochizuki: Phaeomycotic cyst caused
by Exophiala xenobiotica in a patient with rheumatoid arthritis and lung cancer, Med. Mycol. J., 55:151-156, 2014
(in Japanese) .

0490D009

K.Ikemura, T.Fujii, S.Abe, T.Mochizuki, Y.Oikawa: The first case of Amblyomma testudinarium tick bite in
Ishikawa prefecture, Japan, J. Kanazawa. Med. Univ., 39:42-44, 2014 (in Japanese) .

Others
0490F001(M.Maeda), H.Iwata, A.Nakatani, K.Anzawa, T.Mochizuki: A girl infant case of tinea capitus, Annual of Gifu
Prefectual General Medical Center, 35：17-20, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0490I001

T.Mochizuki: Outbreaks of an epidemic of Trichophyton tonsurans infection in Japan, Taiwanese Dermatological
Association Spring Meeting 2014, (Kaohsiung, '14.05).

0490I002

T.Mochizuki: What’s new in 2014: What’s new in fungal skin diseases, Taiwanese Dermatological Association
Spring Meeting 2014, (Kaohsiung, '14.05).

0490I003

K.Takeda, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki: Molecular polymorphism of Trichophyton rubrum
strains cultured from isolates from a Japanese patient with several lesions, 3rd Eastern Asia Dermatology
Congress, (Jeju, '14.10).

－ 84 －

0500

Department of Urology

Faculty
Title

Name

Field of Specialization

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

NAKAI Dan

general urology

Assistant Professor

NAKAZAWA Yusuke

general urology

Assistant Professor

INOUE Shinya

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001

K.Miyazawa, T.Tanaka, D.Nakai, N.Morita, K.Suzuki: Immunohistochemical expression of four different stem cellmarkers in prostate cancer： High expression of NANOG in conjunction with hypoxia-inducible factor-1α
expression is involved in prostate epithelial malignancy, Oncol. Lett., 8:985-992, 2014.

Case Reports
0500D001(K.Kaneko), Y.Matsuta, M.Moriyama, M.Yasuda, N.Chishima, N.Yamaoka, T.Fukuuchi, K.Miyazawa, K.Suzuki:
Proteomic analysis of a rare urinary stone composed of calcium carbonate and calcium oxalate dihydrate： A casereport, Int. J. Urol., 21:341-346, 2014.

0500D002

I.Chikazawa, D.Nakai, M.Morita, H.Tachibana, T.Tanaka, K.Miyazawa, M.Kishibe, Y.Kamimura, E.Kinoshita,
N.Kurose: Skin and lung metastasis from renal cell carcinoma 23 years after radical nephrectomy-a case report-,
Jpn. J. Cancer Clin., 60:537-542, 2014 (in Japanese) .

－ 85 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Professor

MAKINODA Satoru

Professor

Field of Specialization

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines
Gynecologic Pathology, Tumor Virology, Sexually Transmitted
SASAGAWA Toshiyuki
Infection Research, Immunology

Associate
Professor(Additional Post)

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

WASEDA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

YAMAGUCHI Naotaka perinatal medicine

Assistant Professor

OSAKA Yasuhiro

perinatal medicine

Assistant Professor

SAKAMOTO Jinichi

perinatal medicine, reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 86 －

Publications
Originals
0510B001(M.Rahman), A.Hoque, G.Mostofa, S.Makinoda: Association between adolescent marriage and intimate partner
violence:a study of young adult women in Bangladesh, Asia Pac J Public Health., 26:160-168, 2014.

0510B002(K.Shigehara), T.Sasagawa, S.Kawaguchi, K.Nakashima, T.Nakashima, M.Shimamura, K.Furubayashi, M.Namiki:
Cytological evaluation using liquid-based cytology in the male urogenital tract infected with human papillomavirus,
Diagn. Cytopathol., 42:491-497, 2014.

0510B003

Y.Oka, M.Rahman, C.Sasakura, T.Waseda, Y.Watanabe, R.Fujii, S.Makinoda: Prenatal diagnosis of fetal
respiratory function: evaluation of fetal lung maturity using lung-to-liver signal intensity ratio at magnetic
resonance imaging, Prenat. Diagn., 34:1289-1294, 2014.

0510B004(K.Shigehara), T.Sasagawa, M.Namiki: Human papillomavirus infection and pathogenesis in urothelial cells: a minireview, J. Infect. Chemother., 20:741-747, 2014.

Reviews
0510C003

T.Sasagawa, N.Yamaguchi, S.Fujita, H.Takagi, S.Makinoda: HPV infection as an STI:a review of the prophylaxis
and treatment of HPV-related diseases from an immunological point of view, Japanese Journal of Sexually
Transmitted Infections, 25:27-36, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0510I001

Takagi H, Sakamoto J, Yamaguchi N, Fujita S, Sasagawa T, Makinoda S: Relationship between histologic grading
and standardized uptake values (SUV) of PET/CT in endometrial endometrioid carcinoma, International Workshop
on Molecular Functional Imaging for Brain and Gynecologic Oncology, (Fukui, '14.03).

0510I002

Shibata T, Waseda T, Tomizawa H, Fujii R, Makinoda S, Utsunomiya T: Granulocyte colony-stimulating factor: a
new treatment for luteinized unruptured follicle caused by ovulation induction therapy, 9th Women's Health &Disease, (Athena, '14.08).

0510I003

Oka Y, Waseda T, Makinoda S: Prenatal evaluating method of fetal lung maturity using lung-to-liver signal
intensity ratio at magnetic resonance imaging(MRI), 24th ISUOG, (Barcelona, '14.09).

0510I004

Neyatani N, Osaka Y, Waseda T, Sasagawa T, Makinoda s: Advantages and effectiveness of intensity-modulated
radiation therapy(IMRT) for recurrent gynecologic cancer, 15th International Gynecologic Cancer Society,(Melbourne, '14.10).

0510I005

Osaka Y, Takagi H, Neyatani N, Makinoda S: Radiationship between histologic grading and standardized uptake
values(SUV) of PET/CT in endometrial endometrioid carcinoma, 15th International Gynecologic Cancer Society,(Melbourne, '14.10).

－ 87 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

SHIRAISHI Miharu

Clinical anesthesia, Pain medicine, Palliative medicine

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Senior Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, Shock

Senior Assistant Professor

HONMA Keiko

Clinical anesthesia, Palliative medicine

Assistant Professor

NISHIIKE Satoshi

Clinical anesthesia, Nerve block, Vascular reactivity

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity

Assistant Professor

MURATA Yuriko

Clinical anesthesia

Assistant Professor

BEN Asami

Clinical anesthesia

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

TAKANO Mami

Clinical anesthesia

Assistant Professor

MORIKAWA Takanori Clinical anesthesia

Assistant Professor

HARA Keiko

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

－ 88 －

0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Professor

KAGECHIKA Kenji

Senior AssistantProfessor(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0540B001(E.A.Kim), M.Nakata: Work-related musculoskeletal disorders in Korea and Japan: a comparative description, Ann
Occup Environ Med., 26:17;1-7, 2014.

Case Reports
0540D001(Y.Takagi), H.Yamada, Y.Kanazawa, H.Ebara, K.Tanaka, Y.Takata, Y.Kitano, Y.Kitano, K.Kagechika, H.Tsuchiya:
Upper migrated giant central type L1/2 disc herniation treated via the lateral approach by microendoscopyassisted lunbar discectomy, J Spine Res., 5:1212-1217, 2014.

0540D002(Y.Takata), Y.Takagi, H.Yamada, Y.Kanazawa, H.Ebara, K.Takagi, Y.Kitano, K.Kagechika, H.Tsuchiya: Lumbar
foraminal stenosis with lumbar spondylotic spondylolisthesis treated by microendoscopic foraminotomy: a casereport, J Spine Res., 5:1188-1191, 2014.

Presentations at Conference
International Conference (Presentations)
0540I001

K.Kagechika, M.Nakata, M.Tsubokawa, A.Nakanami, Y.Yakagi: By carotid artery echo we can evaluate the change
in the dynamic property of vessel wall ,dynamic deformability and strength of arteriosclerotic and ruptured bloodvessel, The24th Japanese-Korean Combined Orthopaedic Symposium, (Shizuoka, '14.06).

0540I002

K.Kagechika, T.Nakaki, M.Tsubokawa, A.Nakaki, Y.Takagi: Effect of rehabilitation of blood cancer, The 4rd AsiaOceanian Conference of Physical and Rehabilitation Medicine, (Bangkok, '14.12).

－ 89 －

0540I003

T.Terai, T.Hashimoto, Y.Nitta, T.Monkawa, Y.Kawasaki, K.Kagechika: Follow-up of 2 years, the recovery ofsocial function by vocational rehabilitation based on the "IPS"of medical institutions, The 4rd Asia-Oceanian
Conference of Physical and Rehabilitation Medicine, (Bangkok, '14.12).

0540I004

A.Kobe, N.Ikeda, N.Yamazaki, Y.Funami, K.Kagechika, T.Maeno: Incidence and prevention of fall in rehabilitationintervention patients fore five years, The 4rd Asia-Oceanian Conference of Physical and Rehabilitation Medicine,(Bangkok, '14.12).

－ 90 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

IWAI Junichi

Emergency

Assistant Professor

GOTO Tetsuro

Emergency

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

WATANABE Atsushi

Emergency

Assistant Professor

USHIMOTO Tomoyuki Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 91 －

0570

District medical

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Senior AssistantProfessor(Additional Post)

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

Case Reports
0570D001

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

－ 92 －

0575 Department of Gastroenterological Endoscopy
Faculty
Title

Name

Field of Specialization

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
URASHIMA Sachio
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAWAURA Ken
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
ITO Rika
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
ITO Tohru

Professor

Associate Professor

Associate Professor

Senior Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Case Reports
0575D001

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

－ 93 －

Presentations at Conference
International Conference (Synposium)
0575H001

T.Ito: Surgical and oncological evidence of effectiveness,completeness and redical curability of EMR and ESD for
Early Gastric cancer., The 16th Japan-Russia Endoscopy Symposium, (Moscow, '14.02).

0575H002

T.Ito: High definition (ExeraⅢ) white light, narrow-band imaging(NBI)and magnification endoscopy +endocytoscopy in diagnosis of the gastric epithelial neoplasia., The 16th Japan-Russia Endoscopy Symposium,(Moscow, '14.02).

0575H003

T.Ito: Endoscopic submicosal dissection of gastric neoplasia., The 16th Japan-Russia Endoscopy Symposium,(Moscow, '14.02).

－ 94 －

0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Assistant Professor

KATO Koichiro

Oral tumor

Assistant Professor

HASUMOTO Miho

Orthodontics

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0580B001(H.Yoshimura), M.Hasumoto, T.Sugai, N.Segami, N.Kato: Enhancement of oscillatory activity in the endopiriform
nucleus of rats raised under abnormal oral conditions., Neurosci. Lett., 561:162-165, 2014.

Case Reports
0580D001

K.Kato, N.Segami, H.Fukuda, H.Minato: Rheumatoid nodule in the lower lip of a patient with rheumatoid arthritis:
a novel case report and review of literature., J. Oral Maxillofac. Surg., 72:1532.e1-5, 2014.

－ 95 －

University

Hospital

0635

Hepatology

Faculty
Title

Name

Field of Specialization

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Associate Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Senior Assistant Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Senior Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Assistant Professor

SAITO Takashi

Treament for metabolic syndrome

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Hepatic support system for severe alcoholic hepatitis③Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver
３ Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0635B001

K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata,T.Arisawa: The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative
colitis, Mol. Med. Report., 9:28-32, 2014.

0635B002

N.Toshikuni, M.Tsutsumi, Y.takuma, T.Arisawa: Real-time image fusion for successful percutaneousradiofrequency ablation of hepatocellular carcinoma., J Ultrasound Med., 33:2005-2010, 2014.

0635B003

K.Ozaki, N.Toshikuni, J.George, T.Minato, Y.Matsue, T.Arisawa, M.Tsutsumi: Serum endocan as a novel
prognostic biomarker in patients with hepatocellular carcinoma, J Cancer., 5:221-230, 2014.

－ 96 －

0635B004

T.Minato, M.Tsutsumi, M.Tsuchishima, N.Hayashi, T.Saito, Y.Matsue, N.Toshikuni, T.Arisawa, J.George: Binge
alcohol consumption aggravates oxidative stress and promotes pathogenesis of NASH from obesity-lnduced simple
steatosis, Mol. Med., 20:490-502, 2014.

Reviews
0635C001

N.Toshikuni, T.Arisawa, M.Tsutsumi: Hepatitis C-related liver cirrhosis - strategies for the prevention of hepatic
decompensation,hepatocarcinogenesis,and mortality, World J. Gastroenterol., 20:2876-2887, 2014.

0635C002

N.Toshikuni, T.Arisawa, M.Tsutsumi: Nutrition and exercise in the management of liver cirrhosis, World J.
Gastroenterol., 20:7286-7297, 2014.

0635C003

N.Toshikuni, M.Tsutsumi, T.Arisawa: Clinical differences between alcoholic liver disease and nonalcoholic fatty
liver disease, World J. Gastroenterol., 20:8393-8406, 2014.

0635C004

M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi: Involvement of
the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., World J Hepatol., 6:880893, 2014.

0635C005

N.Hayashi, T.Saito, M.Kakuda, Y.Matsue, T.Minato, A.Fukumura, K.Ozaki, M.Tsuchisima, M.Tsutsumi:
Pathogenesis of alcoholic chronic hepatitis, Jpn. J. Alcohol & Drug Dependence, 49:219-226, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0635I001

N.Toshikuni, A.Fukumura, T.Arisawa, M.Tsutsumi: Do types of fatty liver disease influence the susceptibillity of
diabetes mellitus,hepertension,and dyslipidemia?, Didestive Disease Week 2014, (Chicago, '14.05).

0635I002

M.Nakamura, H.Shiroeda, T.Shimasaki, T.Otsuka, N.Toshikuni, T.Fukuyama, K.Matsunaga, R.Hayashi, T.Nomura,
H.Yamada, K.Yamada, N.Kawada, T.Tahara, T.SHibata, T.Arisawa: The usefulness of nasal ESD performed with a
new therapeutic transnasal endoscope for early esophageal cancer, Didestive Disease Week 2014, (Chicago,'14.05).

0635I003

T.Arisawa, T.Fukuyama, T.Tahara, K.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada, T.Otsuka,
M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.SHibata: Genetic polymorphisms of DNMT3A are
associated with the aberrant DNA methylation of CDH1 in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

0635I004

T.Shimasaki, N.Ueda, N.Kawada, T.Nomura, K.Yamada, H.Yamada, R.Hayashi, K.Matsunaga, T.Fukuyama,
T.Otsuka, M.Nakamura, N.Toshikuni, H.Shiroeda, T.Kosaka, N.Tomosugi, T.Minamoto, T.Arisawa: Phase i clinical
trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistantadvanced pancreatic cancer patients, Didestive Disease Week 2014, (Chicago, '14.05).

0635I005

T.Arisawa, T.Otsuka, T.Tahara, K.Yamada, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada,
T.Fukuyama, M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.Shibata: Genetic polymorphisms of DNMT3A
are associated with the aberrant DNA methylation of DAPK in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

0635I006

T.Arisawa, H.Shiroeda, T.Tahara, K.Yamada, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada,
T.Fukuyama, T.Otsuka, M.Nakamura, N.Toshikuni, T.SHibata: A polymorphisms rs7521584 in pre-miR429 andpre-mir200s genes is associated with the aberrant DNA methylation in gastric mucosa, Didestive Disease Week
2014, (Chicago, '14.05).

－ 97 －

0675

Health Evaluation Center

Faculty
Title

Name

Field of Specialization

Professor

ASAJI Takayoshi

Heartfailure

Professor

FURUTA Hisakazu

Clinical study on sleep-wake disorders

Professor(Additional Post)

Epidemiology of cardiovascular diseases, occupational medicine,
NAKAGAWA Hideaki
preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/ Disease and Medical expenditure

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Assistant Professor

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001

X.Zhao, A.Nogawa, T.Matsunaga, T.Takegami, H.Nakagawa, Y.Ishigaki: Proteasome inhibitors and knockdown of
SMG1 cause accumulation of Upf1 and Upf2 in human cells., Int. J. Oncol., 44:222-228, 2014.

0675B002(H.Uzui), H.Hayashi, I.Nakae, T.Matumoto, H.Uenishi, H.Hayasaki, T.Asaji, S.Matsui, M.Kunihisa, JD.Lee,
H.Tada, T.Sawamura, M.Fujita: Pitavastatin decreases serum LOX-1 ligand levels and MT1-MMP expression in
CD14-positive mononuclear cells in hypercholesterolemic patients, Int. J. Cardiol., 176:1230-1232, 2014.

0675B003

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, T.Kido, T.Kido, Y.Naruse,
Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-year risk fortype 2 diabetes mellitus in middle-aged Japanese men, Eur. J. Nutr., 53:251-258, 2014.

0675B004

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

0675B005(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

－ 98 －

0675B006

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

0675B007

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

0675B008

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

0675B009

M.Nishijo, Y.Suwazono, W.Ruangyuttikarn, K.Nambunmee, W.Swaddiwudhipong, K.Nogawa, H.Nakagawa: Risk
assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid
approach of inhabitants living in polluted and non-polluted areas in Thailand, BMC Public Health, 14:702;1-9,
2014.

0675B010

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

0675B011

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

0675B012(Emerging Risk Factors Collaboration), H.Nakagawa, M.Sakurai, K.Nakamura, Y.Morikawa, et al.: Glycatedhemoglobin measurement and prediction of cardiovascular disease., JAMA, 311:1225-1233, 2014.

0675B013(K.Asayama), M.Satoh, Y.Murakami, T.Ohkubo, SY.Nagasawa, I.Tsuji, T.Nakayama, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura, Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCHJAPAN) Research Group, H.Nakagawa, et al.: Cardiovascular risk with and without antihypertensive drug
treatment in the Japanese general population: participant-level meta-analysis., Hypertension, 63:1189-1197, 2014.

0675B014(K.Ishikura), H.Misu, M.Kumazaki, H.Takayama, N.Matsuzawa-Nagata, N.Tajima, K.Chikamoto, F.Lan, H.Ando,
T.Ota, M.Sakurai, Y.Takeshita, K. Kato, A. Fujimura, KI.Miyamoto, Y.Saito, S.Kameo, Y.Okamoto, Y.Takuwa,
K.Takahashi, H.Kidoya, N.Takakura, S.Kaneko, T.Takamura: Selenoprotein P as a diabetes-associated hepatokine
that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells., Diabetologia, 57:1968-1976,
2014.

0675B015(N.Miyagawa), K.Miura, N.Okuda, T.Kadowaki, N.Takashima, SY.Nagasawa, Y.Nakamura, Y.Matsumura,
A.Hozawa, A.Fujiyoshi, T.Hisamatsu, K.Yoshita, A.Sekikawa, T.Ohkubo, RD.Abbott, T.Okamura, A.Okayama,
H.Ueshima, the NIPPON DATA80 Research Group, H.Nakagawa, et al.: Long-chain n-3 polyunsaturated fatty
acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80,
Atherosclerosis, 232:384-389, 2014.

0675B016(A.Okayama), N.Okuda, K.Nakamura, K.Miura, S.Yasumura, K.Sakata, H.Hidaka, T.Okamura, K.Nishimura:
Method for evaluating health promotion programs using propensity score, Health Evaluation and Promotion,
41:418-427, 2014 (in Japanese) .

0675B017(T.Koyama), K.Yoshita, Y.Arai, K.Nakamura, M.Sakurai, M.Nishijo, SY.Nagasawa, Y.Morikawa, M.Tabata,
H.Nakagawa: Relationship between daily intake frequency of meals including a staple food,a main dish and a sidedish and nutrient intake in independent elderly individuals, Journal of Japanese Society of Nutrition and Food
Science., 67:299-305, 2014 (in Japanese) .

Reviews
0675C001

K.Nakamura: Impact of cardiovascular risk factors on medical expenditure: evidence from epidemiological studies
analysing data on health checkups and medical insurance, J. Epidemiol., 24:437-443, 2014.

－ 99 －

0675C002

K.Nakamura, T.Okamura, K.Miura, A.Okayama: Hypertension and medical expenditure in the Japanese population:
Review of prospective studies., World J Cardiol., 6:531-538, 2014.

0675C003

Y.Morikawa: The issue of sleep as a risk for occupational safety, Hokuriku Japanese Journal of Public Health.,
40:17-23, 2014 (in Japanese) .

Others
0675F001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,, Y.
Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-yearrisk for type 2 diabetes mellitus in middle-aged Japanese men., Eur. J. Nutr., 53:1137-1138, 2014.

Presentations at Conference
International Conference (Presentations)
0675I001

M.Sakurai, J.Kobayashi, Y.Takeda, S-Y.Nagasawa, J.Yamakawa, J.Moriya, H.Mabuchi: Abdominal obesity,
metabolic syndrome, and the risk of chronic kidney disease in Japanese males and females., 74th Scientific
Sessions, American Diabetes Association., (San Francisco, '14.06).

0675I002

M.Nishijo, PT.Tai, TN.Nghi, NTN.Anh, H.Nakagawa, S.Maruzeni, HV.Luong, TH.Anh, NV.Trung, PT.Phuong, LK.
Son, T.Kido, Y.Morikawa, H.Nishijo: Effects of dioxin exposure on neurodevelopment and urinary amino acidexcretion of children in exposed areas of Vietnam., The 34th international Symposium on Halogenated Persistent
Organic pollutants-Dioxin 2014, (Madrid, '14.08).

0675I003

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, T.Kido, T.Waseda, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-pdioxin in breast milk increases autistic traits of 3-year-old children in Vietnam., The 3rd International Conferenceof Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

0675I004

TN.Nghi, HD.Manh, PT.Tai, M.Nishijo, H.Nakagawa, T.Kido, H.Nishijo: Dioxins and nonorthor polychlorinatedbiphenyl concentrations in breast milk of Vietnamese nursing mothers living in the largest hot spot of dioxin
contamination., The 3rd International Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok,'14.11).

0675I005(PT.Tai), M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Luong, TH.Anh, TN.Nghi, Y.Morikawa, T.Kido,
H.Nishijo: Dioxin effects on infant development from newborn until 3 years of age., The 3rd International
Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

0675I006

S-Y.Nagasawa, K.Miura, T.Kadowaki, A.Fujiyoshi, T.Ohkubo, S.Kadowaki, A.Kadota, A.Sekikawa, H.Ueshima:
Relationship of plasma asymmetrical dimethylarginine to carotid intima-media thickness in general population in
Japanese: the ERA-JUMP Study and SESSA Study., Nutrition,Physical Activity and Metabolism /Cardiovascular
Disease Epidemiology and Prevention 2014 Scientific Sessions, American Heart Association, (San Franscisco, '14).

－ 100 －

Medical

Research

Institute

7100

Department of Life Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology

Professor

Molecular mechanism of flavivirus replication, interaction with host
TAKEGAMI Tsutomu
cells and viral carcinogenesis

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

TASAKI Takafumi

Protein regulation by the post-translational modifications and its
underlying molecular mechanisms

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Senior Assistant Professor

MURAKAMI Manabu

Pathogenicity of flavivirus isolated from the field-collectedmosquitoes

Senior Assistant Professor

TANIGUCHI Makoto

Molecular and Cellular Biology, Lipid Biochemistry

Research Associate

NAKAMURA Yuka

Molecular and Cellular Biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, "transcriptome, proteome, apoptosis, ultra micro structure", "mouse germ cells, DNA repair, fibroblast
growth factor", tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy

Outline of Research
１．Study on viral replication and pathogenicity
２．Molecular mechanism of carcinogenesis and metastasis
３．Research on plolyploidization and polyploid cells
４．Analyses of transcription and mRNA decay
５．Protein regulation by the post-translational modifications and its underlying molecular mechanisms

Books
7100A001(T.Tsuda), E.Mochizuki, S.Kishida, N.Nemoto, Y.Ishigaki, S.Kuwabata: Room-Temperature Ionic Liquid-Bases
SEM/EDX Techniques for Biological Specimens and in situ Electrode Reaction Observation, Molten Salts
Chemistry and Technology(Marcelle Gaune-Escard, Geir Martin Haarberg, 373-389, Willy, United States ofAmerica, 2014.

Publications
Originals
7100B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, K.Iwabuchi, N.Tomosugi: RNA-binding protein RBM8A (Y14)and MAGOH localize to centrosome in human A549 cells., Histochem. Cell Biol., 141:101-109, 2014.

－ 101 －

7100B002

X.Zhao, A.Nogawa, T.Matsunaga, T.Takegami, H.Nakagawa, Y.Ishigaki: Proteasome inhibitors and knockdown of
SMG1 cause accumulation of Upf1 and Upf2 in human cells., Int. J. Oncol., 44:222-228, 2014.

7100B003

H. Ogiso, M. Taniguchi, S. Araya, S.Aoki, LO.Wardhani, Y. Yamashita, Y. Ueda, T.Okazaki: Comparative analysisof biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS/MS, Metabolites., 4:98-114,
2014.

7100B004

T.Nagai, M.Kanasaki, SP.Srivastava, Y.Nakamura, Y.Ishigaki, M.Kitada, S.Shi, K.Kanasaki, D.Koya: N-acetylseryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition,
Biomed Res Int., 2014:696475;1-12, 2014.

7100B005

K.Kanasaki, S.Shi, M.Kanasaki, J.He, T.Nagai, Y.Nakamura, Y.Ishigaki, M.Kitada, SP.Srivastava, D.Koya:
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice byinhibiting endothelial-to-mesenchymal transition in a therapeutic regimen, Diabetes, 63:2120-2131, 2014.

7100B006(M.Okamoto), M.Fujiwara, M.Hori, K.Okada, M.Fujiwara, F.Yazama, H.Konishi, Y.Xiao, G.Qi, F.Shimamoto,
T.Ota, A.Temme, M.Tatsuka: tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5fluorouracil in HeLa cells., PLoS Genet., 10:e1004639;1-11, 2014.

7100B007

Y.Nakamura, Y.Ishigaki: Immunostaining and time-lapse analysis of vinblastine-induced paracrystal formation inhuman A549 cells., Oncol. Lett., 8:2387-2392, 2014.

7100B008(A.Shimamoto), H.Kagawa, K.Zensho, Y.Sera, Y.Kazuki, M.Osaki, M.Oshimura, Y.Ishigaki, K.Hirashima,
Y.Kodama, S.Yuasa, K.Fukuda, K.Hirashima, H.Seimiya, H.Koyama, T.Shimizu, M.Takemoto, K.Yokote, M.Goto,
H.Tahara: Reprogramming suppresses premature senescence phenotypes of Werner syndrome cells and maintains
chromosomal stability over long-term culture., PLoS ONE, 9:e112900;1-13, 2014.

7100B009(S.Nukuzuma), K.Nakamichi, M.Kamaoka, S.Sugiura, C.Nukuzuma, T.Tasaki, T.Takegami: TNF-α stimulates
efficient JC virus replication in neuroblastoma cells, J. Med. Virol., 86:2026-2032, 2014.

7100B010(E.Tabata), M.Masuda, M.Eriguchi, M.Yokoyama, Y.Takahashi, K.Tanaka, M.Yukitake, E.Horikawa, H.Hara:
Immunopathological significance of ovarian teratoma in patients with anti-N-methyl-D-aspartate receptor
encephalitis, Eur. Neurol., 71:42-48, 2014.

7100B011(M.Akaza), K.Tanaka, M.Tanaka, T.Sekiguchi, T.Misawa, K.Nishina, I.Kawachi, M.Nishizawa, H.Mizusawa,
T.Yokota: Can anti-AQP4 antibody damage the blood-brain barrier?, Eur. Neurol., 72:273-277, 2014.

7100B012(K.Park), K.Tanaka, M.Tanaka: Uhthoff's phenomenon in multiple sclerosis and neuromyelitis optica, Eur. Neurol.,
72:153-156, 2014.

7100B013(K.Kanazawa), R.Matsumoto, A.Shimotake, M.Kinoshita, A.Otsuka, O.Watanabe, K.Tanaka, R.Takahashi, A.Ikeda:
Persisitnt frequent subclinical seizures and memory impairment after clinical remission in smoldering limbic
encephalitis, Epileptic Disord., 16:312-7, 2014.

Reviews
7100C001

Y.Ishigaki, Y.Nakamura, T.Tatsuno: Observation of localization and structure of RNA-protein complexes using
light and electron microscopy, J.Electr.Microsc.Technol.Med.Biol, 28:1-5, 2014.

7100C002

M. Taniguchi, T. Okazaki: The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation andmigration – from cell and animal models to human disorders-, BBA-MOL CELL BIOL L, 1841:692-703, 2014.

7100C005

Y.Ishigaki, T.Tatsuno, Y.Nakamura: Global gene expression analysis with DNA microarray, J. Kanazawa. Med.
Univ., 39:35-41, 2014 (in Japanese) .

7100C007

K.Tanaka: Diagnosis and treatment of paraneoplastic neurologic syndrome, Neurol Therap, 31:153-155, 2014 (inJapanese) .

7100C013

K.Tanaka: Pathogenesis of autoantibodies in demyelinating disorders of the central nervous system, Japanese
Journal of Clinical Medicine, 72:2067-2072, 2014 (in Japanese) .

－ 102 －

Case Reports
7100D001(M.Miyamoto), M.Kinoshita, K.Tanaka, M.Tanaka: Recurrent myeliltis in localized scleroderma, Clin. Neurol.
Neurosurg., 127:140-142, 2014.

7100D002(Y.Yamaguchi), K.Furukawa, T.Yamamoto, Y.Takahashi, K.Tanaka, M.Takahashi: Multifocal encephalopathy andautoimmune-mediated limbic encephalitis following tocilizumab therapy, Intern. Med. J., 53:879-82, 2014.

7100D003(M.Nishio), N.Nishitani, K.Tanaka: A case of acute limbic encephalitis with cerebral salt wasting syndrome, Clinical
Neurology, 54:657-659, 2014 (in Japanese) .

7100D004(D.Yamamoto), T.Uchiyama, T.Bunai, K.Sato, T.Shimizu, K.Tanaka, T.Ohashi: Acute encephalitis with refractory
partial status epilepticus treated with early immunotherapies including plasma exchange:a case report, Clinical
Neurology, 54:715-720, 2014 (in Japanese) .

7100D005(M.Tanaka), K.Tanaka: Relapse in a patient with multiple sclerosis 18months after natalizumab treatment withoutanti-natalisumab neutralizing antibodies, Neurological Medicine, 81:582-584, 2014 (in Japanese) .

Short Communications
7100E001(M.Tanaka), K.Tanaka: Anti-MOG antibodies in adult patients with demyelinating disorders of the central nervous
system, J. Neuroimmunol., 270:98-99, 2014.

7100E002

M.Taniguchi, Y.Ishigaki: Case report of new building works adjacent to RI facility, Japanese Journal of Radiation
Safety Management, 13:177-180, 2014 (in Japanese) .

Others
7100F001(M.Tanaka), K.Tanaka: Dose reduction therapy of fingolimod for Japanese patients with multiple sclerosis:24month experience, Clin. Exp. Neuroimmunol., 5:383-384, 2014.

7100F002(K.Fujita), K.Tanaka, Y.Takahashi: Neuronal antibodies in creutzfeldt-jakob disease, JAMA Neurol., 71:514-515,
2014.

7100F003(T.Kezuka), Dk. Sato, K.Tanaka: Distinction between MOG antibody-positive and AQP4 antibody-positive NMO
spectrum disorders, Neurology, 83:475-476, 2014.

Presentations at Conference
International Conference (Presentations)
7100I001

M. Taniguchi, K. Kitatani, Y. Taguchi, T. Kawanami, T. Takegami, H. Umehara, T. Okazaki: Lysosomal ceramide
generated by acid sphingomyelinase triggers cathepsin B-mediated apoptosis in IL-2-deprived natural killer cells,
Gordon Research Conferences, Glycolipid & Sphingolipid Biology, (Ventura, '14.01).

7100I002

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocyte in a rat spinal cord hemisection model, CSRS AP5 Viet Nam 2014, (Ho Chi Minh, '14.04).

7100I003

K.Tanaka, Y.Li, L.Li Wang, N.Kato, M.Matsui, T.Takegami: Memory disturbance of the mice treaｔed withintraventricular administration of CSF from NMDAR-encephalitis patients, American Academy of Neurology 2014
Aunual Meeting, (Philadelphia, '14.05).

7100I005

K.Iwai, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF regulates the formationof apoptosis by conjugating the two opposite pathways in arterial smooth muscle cell, European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35 (Suppl.) ：612-613, 2014.

7100I006

K.Iwai, T.Okuno, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF isprerequisite for the fetal gene expression in the process of hypertrophy of the cardiomyocyte., European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35：(Suppl.) 954-955, 2014.

－ 103 －

7100I007

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Role of RNA binding
protein in cell cycle progression and centrosome maturation in human tumor cells., 19th World Congress on
Advances in Oncology & 17th International Symposium of Molecular Medicine, (Greece, '14.10).

7100I008

M. Taniguchi, H. Ogiso, Y. Kitagawa, K. Hori, Y. Yamashita, S. Araya, S. Mitsutake, Y. Igarashi, T. Okazaki, T.
Takegami: Deficiency of sphingomyelin synthase 1 prevents attachment and infection of Japanese Encephalitis
Virus, 2nd International Workshop on Molecular Medicine of Sphingolipids, (Kloster Banz,, '14.10).

7100I009

Y.Shimizu, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto: The relevance of hyaluronidase-4 andastrocytes in a rat spinal cord hemisection model, Neuroscience 2014, (Washington,DC, '14.11).

－ 104 －

7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

NIIDA Yo

Genetic disease, Genetic diagnosis

Senior Assistant Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Assistant Professor

SAKASAI Akiko

AGEs, Cell Biology

Research Associate

MURANO Hidekazu

Cardial histology and immunohistochemistry

Researcher

TATSUNO Takanori

chemical biology

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype

Outline of Research
１．Heart failure by autoimmune pathway related with G-protein
２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
３．The role of AGE in the prevention of lifestyle related disease
４．Clinical research for the diagnosis and treatment of pancreatic cancer
５．Development and clinical application of fetal DNA diagnosis using mother’s blood
６．Genetic diagnosis and analysis of hereditary developmental disability
７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Publications
Originals
7200B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, K.Iwabuchi, N.Tomosugi: RNA-binding protein RBM8A (Y14)and MAGOH localize to centrosome in human A549 cells., Histochem. Cell Biol., 141:101-109, 2014.

7200B002

K.Matsunaga, T.Tahara, H.Shiroeda, T.Otsuka, M.Nakamura, T.Shimasaki, N.Toshikuni, N.Kawada, T.Shibata,T.Arisawa: The *1244A>G polymorphism of MyD88(rs7744)is closely associated with susceptibility to ulcerative
colitis, Mol. Med. Report., 9:28-32, 2014.

－ 105 －

7200B003

H. Ogiso, M. Taniguchi, S. Araya, S.Aoki, LO.Wardhani, Y. Yamashita, Y. Ueda, T.Okazaki: Comparative analysisof biological sphingolipids with glycerophospholipids and diacylglycerol by LC-MS/MS, Metabolites., 4:98-114,
2014.

7200B004(I.Nakamura), J.Oyama, H.Komoda, A.Shiraki, Y.Sakamoto, I.Taguchi, A.Hiwatashi, A.Komatsu, M.Takeuchi,
S.Yamagishi, T.Inoue, K.Node: Possible effects of glimepiride beyond glycemic control in patients with type 2
diabetes: a preliminary report., Cardiovasc Diabetol., 13:15;1-8, 2014.

7200B005(H.Hachiya), Y.Miura, K.Inoue, K.H.Park, M.Takeuchi, K.Kubota: Advanced glycation end products impair
glucose-induced insulin secretion from rat pancreatic β-cells., J Hepatobiliary Pancreat Sci., 21:134-141, 2014.

7200B006(K.Takasawa), N.Tomosugi, C.Takaeda, T.Maeda, N.Ueda: Regulation of hepcidin-25 by short- and long-acting
rhEPO may be dependent on ferritin and predict the response to rhEPO in hemodialysis patients., Nephron Extra.,4:55-63, 2014.

7200B007(A.Ojima), T.Matsui, S.Maeda, M.Takeuchi, H.Inoue, Y.Higashimoto, S.Yamagishi: DNA aptamer raised against
advanced glycation end products inhibits melanoma growth in nude mice., Lab. Invest., 94:422-429, 2014.

7200B008(H.Kitade), T.Shimasaki, S.Igarashi, H.Sakuma, M.Mori, N.Tomosugi, M.Nakai: Long-term administration andefficacy of oxaliplatin with no neurotoxicity in a patient with rectal cancer: Association between neurotoxicity and
the GSTP1 polymorphism., Oncol. Lett., 7:1499-1502, 2014.

7200B009(T.Nozue), S.Yamagishi, M.Takeuchi, T.Hirano, S.Yamamoto, S.Tohyama, K.Fukui, S.Umezawa, Y.Onishi,
T.Kunishima, K.Hibi, M.Terashima, I.Michishita: Effect of statins on the serum soluble form of receptor foradvanced glycation end-products and its association with coronary atherosclerosis in patients with angina
pectoris., IJC Metab Endocr., 4:47-52, 2014.

7200B010(S.Nakashima), T.Matsui, M.Takeuchi, S.Yamagishi: Linagliptin blocks renal damage in type 1 diabetic rats bysuppressing advanced glycation end products-receptor axis., Horm. Metab. Res., 46:717-721, 2014.

7200B011(S.Maeda), T.Matsui, A.Ojima, M.Takeuchi, S.Yamagishi: Sulforaphane inhibits advanced glycation end productinduced pericyte damage by reducing expression of receptor for advanced glycation end products., Nutr Res.,
34:807-813, 2014.

7200B012(N.Sugimoto), O.Shido, K.Matsuzaki, M.Katakura, Y.Hitomi, M.Tanaka, T.Sawaki, Y.Fujita, T.Kawanami,
Y.Masaki, T.Okazaki, H.Nakamura, S.Koizumi, A.Yachie, H.Umehara: Long-term heat exposure prevents hypoxiainduced apoptosis in mouse fibroblast cells, Cell Biochem. Biophys., 70:301-307, 2014.

7200B013

T. Takata, Y. Motoo, N. Tomosugi: Effect of saikokeishito, a kampo medicine, on hydrogen peroxide-inducedpremature senescence of normal human dermal fibroblasts, J Integr Med., 12:495-503, 2014.

7200B014(K.Yanagisawa), J.Ashihara, S.Obata, N.Wada, M.Takeuchi, Y.Nishino, S.Maeda, Y.Ishibashi, S.Yamagishi:
Switching to multiple daily injection therapy with glulisine improves glycaemic control, vascular damage andtreatment satisfaction in basal insulin glargine-injected diabetic patients., Diabetes Metab. Res. Rev., 30:693-700,2014.

7200B015(Z.Dong), D.Iwata, N.Kitaichi, M.Takeuchi, M.Sato, N.Endo, K.Iwabuchi, R.Ando, J.Fukuhara, S.Kinoshita,
A.Lennikov, M.Kitamura, K.Mizuuchi, A.Kanda, K.Noda, K.Namba, S.Yamagishi, S.Ohno, S.Ishida: Amelioration ofexperimental autoimmune uveoretinitis by inhibition of glyceraldehyde-derived advanced glycation end-productformation., J. Leukoc. Biol., 96:1077-1085, 2014.

7200B016

Y.Motoo, I.Arai, K,Tsutani: Use of Kampo diagnosis in randomized controlled trials of Kampo products in Japan: asystematic review, PLoS ONE, 9:e104422;1-9, 2014.

7200B017

Y.Fujita, T.Fujii, T.Mimori, T.Sato, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Kawanami, M.Tanaka,
Y.Masaki, T.Fukushima, T.Okazaki, H.Umehara: Deficient leptin signaling ameliorates systemic lupus
erythematosus lesions in MRL/Mp-Faslpr mice, J. Immunol., 192:979-984, 2014.

7200B018(T. Ohye), H.Inagaki, M.Ozaki, T.Ikeda, H.Kurahashi: Signature of backward replication slippage at the copy
number variation junction, J. Hum. Genet., 59:247-250, 2014.

7200B020(T.Mochizuki), C.Tanji, K.Usui, S.Shoji, T.Shinomiya, M.Inaba, N.Tomosugi: A prospective study on the
improvement of EPO resistance index by better iron cycling with lower ferritin management in hemodialysis
patients(EPOCH study), J. Jpn. Soc. Dial. Ther., 47:313-321, 2014 (in Japanese) .

－ 106 －

7200B021(K.Tsutani), K.Yukawa, M.Nagasawa, I.Arai, A.Igarashi, H.Ogasawara, K.Tsuruoka, S.Fukuyama, Y.Motoo,
Y.Yamazaki: Survey on health hazards indirectly caused by complementary and alternative medicine in Japan,
Japanese Pharmacology & Therapeutics., 42:1005-1014, 2014 (in Japanese) .

Reviews
7200C001

M. Taniguchi, T. Okazaki: The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation andmigration – from cell and animal models to human disorders-, BBA-MOL CELL BIOL L, 1841:692-703, 2014.

7200C002

M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda, M.Tsutsumi, H.Hyogo, S.Yamagishi: Involvement of
the TAGE-RAGE system in non-alcoholic steatohepatitis: Novel treatment strategies., World J Hepatol., 6:880893, 2014.

7200C006

Y.Ishigaki, T.Tatsuno, Y.Nakamura: Global gene expression analysis with DNA microarray, J. Kanazawa. Med.
Univ., 39:35-41, 2014 (in Japanese) .

Case Reports
7200D001(K.Fujiwara), T.Fukuhara, H.Kitano, T.Okazaki: Infiltration of the thyroid Gland by T-cell prolymphocytic
leukemia, Thyroid., 24:1314-1318, 2014.

7200D002

J.Moriya, K.Takeuchi, H.Uenishi, S.Akazawa, Y.Motoo, H.Hashimoto, M.Kaneshima, J.Kobayashi, J.Yamakawa:
Successful treatment of post-influenza chronic fatigue syndrome with kampo medicine:a case report, Japanesejournal of oriental medicine., 65:87-93, 2014 (in Japanese) .

7200D003

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi: Treatment with kampo medicines fo reflex sympathetic
dystrophy, post-optic nerve meningioma operation and traffic injury, Pain and kampo medicine., 24:144-148, 2014
(in Japanese) .

7200D004(H.Nakaoka), N,Igarashi, Y.Yamaguchi, S.Siona, H.Higashiyama, S.Fujita, T.Futatani, K.Hatasaki, Y.Niida:
PRKAR1A mutation in a patient with acrodysostosis and hormane resistance, Japanese journal of pediatrics.,
67:1058-1063, 2014 (in Japanese) .

Short Communications
7200E001(T.Wada), M.Ito, H.Maeba, T.Toma, Y.Niida, Y.Saikawa, A.Yachie: Intermittent X-Linked thrombocytopenia witha novel WAS gene mutation, Pediatr Blood Cancer, 61:746-748, 2014.

Others
7200F001(M.Shimizu), Y.Niida, S.Koizumi, A.Yachie: An infant with recurrent convulsive seizures of 3 weeks duration:
Questions, Pediatr. Nephrol., 29:1951, 2014.

7200F002(T.Efferth), S.Lee, Y.Motoo, S.Schröder: Acupuncture and herbal medicine for cancer patients 2014, Evid BasedComplement Alternat Med, 2014,326179;1-2, 2014.

Presentations at Conference
International Conference (Synposium)
7200H001

Y.Motoo: Role of Kampo medicine in multidisciplinary cancer therapy, 2014 Workshop on Integrative Medicine,
Association of Korean Integrative Medicine (AKIM), (Seoul, '14.02).

7200H002

Y.Motoo: Advancements and challenges relevant to integrative traditional and modern medicine in the world:
Japan, 2014 Integrative Traditional and Modern Medicine International Forum, (Taipei, '14.11).

－ 107 －

7200H003

T.Shimasaki: Identification of the GSK3 beta-mediated secretory protein responsible for GEM-induced EMT inpancreatic cancer cells．, The 25th Annual Meeting of the Japanese Society for Gastroenterological
Carcinogenesis, (Fukuoka, '14.11).

International Conference (Presentations)
7200I001

Y.Motoo: Integrative cancer medicine in Japan, 2014 International Conference on Integrative Medicine,
Association of Korean Integrative Medicine (AKIM), (Seoul, '14.02).

7200I002(N.Kawada), K.Matsunaka, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y,Tomita: Usefulness ofdual phase 18F-FDG-PET/CT for distinguishing malignancy from benign small pancreatic tumors, Didestive
Disease Week 2014, (Chicago, '14.05).

7200I003

M.Nakamura, H.Shiroeda, T.Shimasaki, N.Kawada, T,Tahara, T,Shibata, T.Arisawa: Usefulness of the packageadhesion method with four-place clip polyglycolic acid sheets for preventing bleeding from ulcers after early gastriccancer endoscopic submucosal dissection, Didestive Disease Week 2014, (Chicago, '14.05).

7200I004

M.Nakamura, H.Shiroeda, T.Shimasaki, T.Otsuka, N.Toshikuni, T.Fukuyama, K.Matsunaga, R.Hayashi, T.Nomura,
H.Yamada, K.Yamada, N.Kawada, T.Tahara, T.SHibata, T.Arisawa: The usefulness of nasal ESD performed with a
new therapeutic transnasal endoscope for early esophageal cancer, Didestive Disease Week 2014, (Chicago,'14.05).

7200I005

T.Arisawa, T.Fukuyama, T.Tahara, K.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada, T.Otsuka,
M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.SHibata: Genetic polymorphisms of DNMT3A are
associated with the aberrant DNA methylation of CDH1 in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

7200I006

T.Shimasaki, N.Ueda, N.Kawada, T.Nomura, K.Yamada, H.Yamada, R.Hayashi, K.Matsunaga, T.Fukuyama,
T.Otsuka, M.Nakamura, N.Toshikuni, H.Shiroeda, T.Kosaka, N.Tomosugi, T.Minamoto, T.Arisawa: Phase i clinical
trial of the combination therapy using gemcitabine and GSK3beta inhibiting drugs for gemcitabine-resistantadvanced pancreatic cancer patients, Didestive Disease Week 2014, (Chicago, '14.05).

7200I007(N.Kawada), K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y.Tomita: NOdule sizeand positive cytology as predictors of malignancy for intraductal papillary mucinous neoplasm of the pancreas,
Didestive Disease Week 2014, (Chicago, '14.05).

7200I008(N.Kawada), K.Matsunaga, T.Otsuka, M.Nakamura, T.Shimasaki, H.Shiroeda, T.Arisawa, Y.Tomota: Morphologicalchanges of intraductal papillary mucinous neoplasm of the pancreas are not enough for indicators of thedevelooment of pancreatic carcinoma during follow up, Didestive Disease Week 2014, (Chicago, '14.05).

7200I009

T.Arisawa, T.Otsuka, T.Tahara, K.Yamada, H.Yamada, T.Nomura, R.Hayashi, K.Matsunaga, N.Kawada,
T.Fukuyama, M.Nakamura, T.Shimasaki, N.Toshikuni, H.Shiroeda, T.Shibata: Genetic polymorphisms of DNMT3A
are associated with the aberrant DNA methylation of DAPK in japanese subjects, Didestive Disease Week 2014,(Chicago, '14.05).

7200I010(K. Taguchi), K. Fukami, S. Yamagishi, Y. Higashimoto, M. Yokoro, N. Obara, R. Ando, Y. Nakayama, T. Matsui,
M. Takeuchi, S. Ueda, S. Okuda: DNA-aptamer raised against RAGE blocks the progression of experimental
diabetic neuropathy., The 14th Asian Pacific Congress of Nephrology (APCN 2014) 2014, (Tokyo, '14.05).

7200I011

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Role of RNA binding
protein in cell cycle progression and centrosome maturation in human tumor cells., 19th World Congress on
Advances in Oncology & 17th International Symposium of Molecular Medicine, (Greece, '14.10).

7200I012

Y.Motoo, I.Arai, K.Tsutani: Use of Kampo diagnosis in randomized controlled trials of Kampo products in Japan: asystematic review, 2014 Integrative Traditional and Modern Medicine International Forum, (Taipei, '14.11).

－ 108 －

7310

Division of HT Research

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate
Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Postdoctoral Researcher

MATSUDA Yukihisa

cognitive psychology brain science

Postdoctoral Researcher

WANG Min

Neurophysiology

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
7310B001(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

7310B002

M.Nishijo, Y.Suwazono, W.Ruangyuttikarn, K.Nambunmee, W.Swaddiwudhipong, K.Nogawa, H.Nakagawa: Risk
assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid
approach of inhabitants living in polluted and non-polluted areas in Thailand, BMC Public Health, 14:702;1-9,
2014.

7310B003

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

7310B004

M.Nishijo, PT.Tai, TNA.Nguyen, TN.Nghi, H.Nakagawa, HV,Luong, AH.Tran, Y.Morikawa, HD.Manh, T.Kido,
MN.Nui, NM.Hai, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-yearold children in Vietnam., Mol. Psychiatry., 19:1220-1226, 2014.

7310B005(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women., Eur. J. Endocrinol., 170:131-139, 2014.

7310B006(HD.Manh), T.Kido, R.Okamoto, S.Xianliang, Le T.Anh, S.Supratman, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, T.Nakano, T.Takasuga, DD.Nhu, NN. Hung, LK.Son: Serum dioxin levels in vietnamese men more than
40 years after herbicide spraying., Environ. Sci. Technol., 48:3496-3503, 2014.

－ 109 －

7310B007(H.Suzuki), T.Kido, R.Okamoto, DD.Nhu, M.Nishijo, H.Nakagawa, K.Tawara, H.Horikawa, Y.Sato, PT.Dung,
LH.Thom, NN.Hung: The relationship between dioxin congeners in the breast milk of Vietnamese women and sister
chromatid exchange., Int. J. Mol. Sci., 15:7485-7499, 2014.

7310B008(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa: Impact of urinary
cadmium on mortality in the Japanese general population in cadmium non-polluted areas., Int. J. Hyg. Environ.
Health., 217:807-812, 2014.

7310B009

Y.Matsuda, S.Takemoto, R.Hashimoto, A.Tamai, T.Kanda, M.Ishizaki, T.Miwa, S.Morimoto, O.Kitamura,Y.Kawasaki: Implementation report of screening investigation of dementia for inhabitants of rural areas in
Himi,Toyama, J. Kanazawa. Med. Univ., 39:67-74, 2014 (in Japanese) .

7310B010(T.Koyama), K.Yoshita, Y.Arai, K.Nakamura, M.Sakurai, M.Nishijo, SY.Nagasawa, Y.Morikawa, M.Tabata,
H.Nakagawa: Relationship between daily intake frequency of meals including a staple food,a main dish and a sidedish and nutrient intake in independent elderly individuals, Journal of Japanese Society of Nutrition and Food
Science., 67:299-305, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
7310I001

M.Nishijo, PT.Tai, TN.Nghi, NTN.Anh, H.Nakagawa, S.Maruzeni, HV.Luong, TH.Anh, NV.Trung, PT.Phuong, LK.
Son, T.Kido, Y.Morikawa, H.Nishijo: Effects of dioxin exposure on neurodevelopment and urinary amino acidexcretion of children in exposed areas of Vietnam., The 34th international Symposium on Halogenated Persistent
Organic pollutants-Dioxin 2014, (Madrid, '14.08).

7310I002

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, T.Kido, T.Waseda, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-pdioxin in breast milk increases autistic traits of 3-year-old children in Vietnam., The 3rd International Conferenceof Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

7310I003

TN.Nghi, HD.Manh, PT.Tai, M.Nishijo, H.Nakagawa, T.Kido, H.Nishijo: Dioxins and nonorthor polychlorinatedbiphenyl concentrations in breast milk of Vietnamese nursing mothers living in the largest hot spot of dioxin
contamination., The 3rd International Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok,'14.11).

7310I004(PT.Tai), M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Luong, TH.Anh, TN.Nghi, Y.Morikawa, T.Kido,
H.Nishijo: Dioxin effects on infant development from newborn until 3 years of age., The 3rd International
Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

－ 110 －

7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Assistant
Professor(Additional Post)

HATSUSAKA Natsuko ophthalmological optics

Researcher

TSAI Cheng yu

electromagnetic ocular injury

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, "glaucoma, age related maculardegeneration", "JICA, WHO, outdoor temperature, risk factors search", "Reykjavik eye study, Monzen eye study","Liaoning eye study, racial differences"

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
7320B001

N.Mita, H.Sasaki, K.Kani, A.Tabuchi, H.Hara: Multiple comparisons for a psychophysical test in bootstrap logistic
regression, J Algorithm Comput Technol., 8:339-355, 2014.

7320B002(K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki,
M.Taki, Y.Kamimura, A.Hirata, H.Shirai: Dosimetry using a localized exposure system in the Millimeter-Waveband for in vivo studies on ocular effects, IEEE Trans. Microw. Theory Tech., 62:1554-1564, 2014.

7320B003

A.Arimoto, K.Kitagawa, N.Mita, Y.Takahashi, E.Shibuya, H.Sasaki: Effect of rebamipide ophthalmic suspension on
signs and symptoms of keratoconjunctivitis sicca in sjogren syndrome patients with or without punctal occlusions,
Cornea, 33:806-811, 2014.

7320B004(T.Tokutake), T.Yamauchi, N.Mita, Ken-ichiro Kawamoto, H.Tabuchi, K.Kani, H.Hara, A.Tabuchi, H.Sasaki:
Pepeatability of visua acuity testing using a psychometric function, Jpn. J. Ophthalmol., 58:381-387, 2014.

7320B005

N.Hatsusaka, K.Sasaki, Y.Kawakami, M.Sasaki, H.Sasaki: Evaluation of casey eye Institute camera forphotographic documentation of opaque crystalline lens, Japanese journal of clinical ophthalmology Rinsho ganka.,
68:1413-1420, 2014 (in Japanese) .

－ 111 －

Presentations at Conference
International Conference (Presentations)
7320I001

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosi: Its relationship to posterior capsule
opacity, International Conference on the Lens, (Hawaii, '14.01).

7320I002

H.Sasaki, N.Hatsusaka, N.Shibata, S.Shibata, Y.Kurihara, CY.Tsai, E.Kubo: Comparison of ocular UV exposure byfacial contour, International Conference on the Lens, (Hawaii, '14.01).

7320I003

N.Hatsusaka, N.Shibata, S.Shibata, N.Fujita, H.Osada, E.Kubo, H.Sasaki: Correlation of UV eposure dose between
top of head and eye, International Conference on the Lens, (Hawaii, '14.01).

7320I004

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki: Lens damage
induced by 40 GHz millimeter wave, International Conference on the Lens, (Hawaii, '14.01).

7320I005

T.Shibata, S.Shibata, E.Kiyokawa, H.Sasaki, E.Kubo: Tropomyosi: Inhibition of progression of sugar cataract ingalactose-fed rats and induction of anti-oxidant protein, Peroxiredoxin 6, International Conference on the Lens,(Hawaii, '14.01).

7320I006(P.Steinkamp), K.Sasaki, N.Hatsusaka, F.Fraunfelder, H.Sasaki: Correlating retroillumination images of lens
opacity subtype with the change in vision, World Ophthalmology Congress of the International Council ofOphthalmology, (Tokyo, '14.04).

7320I007

N.Mita, H.Osada, N.Shibata, E.Kubo, H.Sasaki: Influential factors in transparent crystalline lens accommodation,
World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

7320I008

A.Okamoto, M.Sasaki, Y.Takahashi, E.Kubo, H.Sasaki: Correlation between axial length and visual function of eyewith aspheric IOL, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

7320I009

E.Shibuya, M.Takahashi, M.Sasaki, A.Okamoto, H.Sasaki: Pupil diameter size and visual funtion in eyes withmultifocal intraocular lens, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo,'14.04).

7320I010

M.Takahashi, H.Osada, S.Enta, M.Sasaki, H.Sasaki: Correlation between visual acuity and contrast acuity by typeof lens opacity, World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

7320I011(M.Tamura), N.Hatsusaka, Y.Sakamoto, HM.Cheng, H.Sasaki: Regional differences infactors for ocular refraction
related to myopia progression among teenagers linving in east asia, World Ophthalmology Congress of theInternational Council of Ophthalmology, (Tokyo, '14.04).

7320I012

N.Hatsusaka, Y.Sakamoto, K.Sasaki, E.Kubo, H.Sasaki: 10 years change in corneal astignatism with aging, World
Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

7320I013

M.Fukuda, S.Shibata, H.Osada, E.Kubo, H.Sasaki: Delayed corneal wound healing resulting from theadministration of fluoroquinolone antibacterial ophthalmic solutions and its causes, World Ophthalmology Congressof the International Council of Ophthalmology, (Tokyo, '14.04).

7320I014

H.Sasaki, N.Hatsusaka, N.Fujita, S.Shibata, E.Kubo: Relationship between UV index and ocular UV-B exposure,World Ophthalmology Congress of the International Council of Ophthalmology, (Tokyo, '14.04).

7320I015

E.Kubo, H.Osada, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh: Tropomyosin regulation of stress fiber formationand EMT in lens epithelial cells, Association for Research in Vision and Ophthalmology, (Orlando, '14.05).

7320I016

S.Shibata, DP.Singh, N.Shibata, H.Sasaki, E.Kubo: Hyperglycemia- and oxidative stress-induced hyperoxidation of
Prdx 6 during lens epithelial cell damage and rat lens opacity in vitro and in vivo, Association for Research in
Vision and Ophthalmology, (Orlando, '14.05).

7320I017

N.Shibata, K.Sasaki, N.Yamanaka, N.Hatsusaka, H.Sasaki: Applicability of detecting auto fluorescence as early
sign of pinguecula, Association for Research in Vision and Ophthalmology, (Orlando, '14.05).

7320I018

H.Sasaki, N.Hatsusaka, N.Shibata, S.Shibata, Y.Kurihara, CY.Tsai, E.Kubo: Influence of difference between asian
and western facial contours on ocular UV exposure, Association for Research in Vision and Ophthalmology,(Orlando, '14.05).

－ 112 －

7320I019(J.Chakarothai), M.Kojima, Kensuke Sasaki, K.Wake, Y.Suzuki, M.Taki, S.Watanabe: Millimeter-wave power
absorbed into rabbit eye due to different exposure environments, EMC2014, (Tokyo, '14.05).

7320I020

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, M.Taki, K.Sasaki,
H.Sasaki: Millimeter wave exposure induces cornea and lens epithelium damage, BioEM2014, (Cape Town, '14.06).

7320I021

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: 75 GHz millimeter wave exposure to eye: role of environment factors in effects, BioEM2014, (CapeTown, '14.06).

7320I022

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Effect of relative Humidity during 40 GHz millimeter wave exposure, 31th URSI General Assembly and
Scientific Symposium, (Beijing, '14.08).

7320I023

H.Sasaki, N.Hatsusaka, M.Takahashi, N.Shibata, Y.Takahashi, K.Sasaki, E.Kubo: 10 years change in refractive
power of crystalline lens and relationship with opacification type in eyes with water clefts, XXXII Congress of the
ESCRS, (Londonn, '14.09).

7320I024

M.Kojima, CY.Tsai, T.Okuno, K.Sasaki, K.Sasaki, H.Sasaki: Ocular temperature measurements during infrared or
millieter wave exposure, 39th International Conference on Infrared, Millimeter, and THz Waves, (Tucson, '14.09).

7320I025

H.Sasaki, N.Mita, N.Hatsusaka, M.Takahashi, E.Shibuya, M.Sasaki, S.Enta, Y.Takahashi, T.Shibata, K.Sasaki,
E.Kubo: Visual function of eyes by five types of lens opacities, 13th Congress of the International Society ofOcular Toxicology, (Kanazawa, '14.10).

7320I026

H.Osada, N.Hatsusaka, E.Shibuya, M.Sasaki, M.Takahashi, A.Nakano, E.Kubo, T.Abe, K.Tsubota, H.Sasaki:
Data-analysis pre-study of initial lenticular findings in emergency workers at Tokyo Electric Power Fukushima
Nuclear Power Plant, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I027

K.Kitagawa, N.Shibata, Y.Takahashi, K.Hagiwara, H.Sasaki: Adverse effects of topical anti-glaucomatous agents inpatients with severe dry eye, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I028

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Sasaki, H.Sasaki: Effects of environmental factors during
millimeter wave exposure, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I029

M.Fukuda, K.Sasaki, H.Sasaki: Cytotoxic effects of 4 OTC ophthalmic solutions on cultured rabbit corneal cellline, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I030

A.Arimoto, K.Nagai, R.Honda, H.Osada, S.Shibata, T.Shibata, E.Kubo, H.Sasaki: Lens pathological change after
intravitreal injection of bevacizumab, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa,'14.10).

7320I031

S.Shibata, K.Kitagawa, T.Shibata, N.Shibata, K.Hagihara, H.Sasaki: Eye disorders associated with colored contactlenses: 3 case studies, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I032

N.Hatsusaka, H.Sasaki: Measurement of ocular UV exposure with mannequin UV sensors, 13th Congress of theInternational Society of Ocular Toxicology, (Kanazawa, '14.10).

7320I033

N.Mita, N.Hatsusaka, E.Shibuya, M.Sasaki, S.Enta, Y.Takahashi, T.Shibata, K.Sasaki, E.Kubo, H.Sasaki: Visualfunction of cataract sub-types, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa,'14.10).

7320I034

N.Shibata, K.Sasaki, N.Hatsusaka, N.Yamanaka, H.Sasaki: Auto-fluorescence is an early sign of developing
pinguecula, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

－ 113 －

7330

Division of Dermatomycology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Assistant
Professor(Additional Post)

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Publications
Originals
7330B001

T.Iwanaga, K.Anzawa, T.Mochizuki: Quantification of dermatophyte viability for evaluation of antifungal effect by
quantitative PCR, Mycopathologia, 177:241-249, 2014.

7330B002(R.Kano), E.Yoshida, T.Yaguchi, V.Hubka, K.Anzawa, T.Mochizuki, A.Hasegawa, H.Kamata: Mating type gene
(MAT1-2) of Trichophyton verrucosum, Mycopathologia, 177:87-90, 2014.

Case Reports
7330D002

K.Takeda, K.Anzawa, T.Mochizuki: A case of thermal burn on the extensor surface of forearm caused by asmartphone, The Japanese Journal of Dermatology, 124:1149-1151, 2014 (in Japanese) .

7330D003(A.Takeuchi), Y.Hamaguchi, M.Fujimoto, K.Takehara, K.Anzawa, T.Mochizuki: A case of deep cutaneous mycosis
by Scedosporium apiospremum in a pemphigus foliaceus patient under immunosuppressive condition, The Japanese
Journal of Dermatology, 124:1135-1140, 2014 (in Japanese) .

7330D004

M.Nanbu, K.Kojima, J.Hatta, K.Takeda, T.Fujii, H.Tanabe, T.Mochizuki: A case of erosive pustular dermatosis of
the scalp fairly well improved by topical application of corticosteroid, Skin research, 13:189-193, 2014 (inJapanese) .

7330D005(S.Urano), Y.Suzuki, K.Anzawa, T.Ohishi, S.Kuroishi, N.Itoh, T.Okada, T.Mochizuki: Phaeomycotic cyst caused
by Exophiala xenobiotica in a patient with rheumatoid arthritis and lung cancer, Med. Mycol. J., 55:151-156, 2014
(in Japanese) .

－ 114 －

7330D007

K.Ikemura, T.Fujii, S.Abe, T.Mochizuki, Y.Oikawa: The first case of Amblyomma testudinarium tick bite in
Ishikawa prefecture, Japan, J. Kanazawa. Med. Univ., 39:42-44, 2014 (in Japanese) .

Others
7330F001(M.Maeda), H.Iwata, A.Nakatani, K.Anzawa, T.Mochizuki: A girl infant case of tinea capitus, Annual of Gifu
Prefectual General Medical Center, 35：17-20, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
7330I001

T.Mochizuki: Outbreaks of an epidemic of Trichophyton tonsurans infection in Japan, Taiwanese Dermatological
Association Spring Meeting 2014, (Kaohsiung, '14.05).

7330I002

T.Mochizuki: What’s new in 2014: What’s new in fungal skin diseases, Taiwanese Dermatological Association
Spring Meeting 2014, (Kaohsiung, '14.05).

7330I003

K.Takeda, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki: Molecular polymorphism of Trichophyton rubrum
strains cultured from isolates from a Japanese patient with several lesions, 3rd Eastern Asia Dermatology
Congress, (Jeju, '14.10).

－ 115 －

7340

Division of Anticipatory Molecular Food Science and Technology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOYA Daisuke

diabetes, hypertension, obesity, aging

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior AssistantProfessor(Additional Post)
Senior AssistantProfessor(Additional Post)

Publications
Originals
7340B001

T.Nagai, M.Kanasaki, SP.Srivastava, Y.Nakamura, Y.Ishigaki, M.Kitada, S.Shi, K.Kanasaki, D.Koya: N-acetylseryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition,
Biomed Res Int., 2014:696475;1-12, 2014.

7340B002(FA.Pena), K.Kanasaki, M.Kanasaki, S.Vong, C.Rovira, R.Kalluri: Specific activation of K-rasG12D allele in the
bladder urothelium results in lung alveolar and vascular defects, PLoS ONE, 9:e95888;1-9, 2014.

7340B003(M.Yasuda), Y.Tanaka, S.Kume, Y.Morita, M.Chin-Kanasaki, H.Araki, K.Isshiki, S.Araki, D.Koya, M.Haneda,
A.Kashiwagi, H.Maegawa, T.Uzu: Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal
localization and apoptosis in podocytes, BBA. Mol. Basis Dis., 1842:1097-1108, 2014.

7340B004(S.Kume), S.Araki, N.Ono, A.Shinhara, T.Muramatsu, H.Araki, K.Isshiki, K.Nakamura, H.Miyano, D.Koya,
M.Haneda, S.Ugi, H.Kawai, A.Kashiwagi, T.Uzu, H.Maegawa: Predictive properties of plasma amino acid profile for
cardiovascular disease in patients with type 2 diabetes, PLoS ONE, 9:e101219;1-7, 2014.

7340B005

K.Kanasaki, S.Shi, M.Kanasaki, J.He, T.Nagai, Y.Nakamura, Y.Ishigaki, M.Kitada, SP.Srivastava, D.Koya:
Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice byinhibiting endothelial-to-mesenchymal transition in a therapeutic regimen, Diabetes, 63:2120-2131, 2014.

Reviews
7340C001

M.Kitada, S.Kume, D.Koya: Role of sirtuins in kidney disease, Curr. Opin. Nephrol. Hypertens., 23:75-79, 2014.

7340C002(S.Kume), K.Yamahara, M.Yasuda, H.Maegawa, D.Koya: Autophagy: emerging therapeutic target for diabetic
nephropathy, Semin. Nephrol., 34:9-16, 2014.

7340C003

D.Koya, M.Kitada, S.Kume, K.Kanasaki: Interventions against nutrient-sensing pathways represent an emerging
new therapeutic approach for diabetic nephropathy, Clin. Exp. Nephrol., 18:210-213, 2014.

7340C004

K.Kanasaki, T.Nagai, K.Nitta, M.Kitada, D.Koya: N-acetyl-seryl-asparatyl-lysyl-proline: a valuable endogenous
anti-fibrotic peptide for combating kidney fibrosis in diabetes, Front Pharmacol., 5:1-11, 2014.

7340C005

S.Shi, Y.He, D.Koya, K.Kanasaki: Cancer biology in diabetes, J Diabetes Investig, 5:251-264, 2014.

7340C006(Japanese Society of Nephrology), K.Kanasaki, M.Kitada, D.Koya: Evidence-based clinical practice guideline for
CKD 2013, Clin. Exp. Nephrol., 18:346-423, 2014.

7340C007

M.Kitada, K.Kanasaki, D.Koya: Clinical therapeutic strategies for early stage of diabetic kidney disease, World J
Diabetes., 5:342-356, 2014.

7340C008(C.Gao), W.Huang, K.Kanasaki, Y.Xu: The role of ubiquitination and sumoylation in diabetic nephropathy, Biomed
Res Int., 2014:160692;1-11, 2014.

－ 116 －

7340C009(S.Kume), D.Koya, T.Uzu, H.Maegawa: Role of nutrient-sensing signals in the pathogenesis of diabetic
nephropathy, Biomed Res Int., 2014:315494;1-9, 2014.

7340C010

T.Otoda, K.Kanasaki, D.Koya: Low-protein diet for diabetic nephropathy, Curr. Diab. Rep., 14:523;1-10, 2014.

7340C011

SP.Srivastava, S.Shi, D.Koya, K.Kanasaki: Lipid mediators in diabetic nephropathy, Fibrogenesis Tissue Repair,
7:1-10, 2014.

7340C012(M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa,
M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide: A new classification ofdiabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Diabetol Int., 5:207-211, 2014.

7340C018(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K,Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K.Shide: Classification of diabetic nephropathy 2014, J. Jpn. Soc. Dial. Ther., 47:415-419, 2014 (inJapanese) .

7340C019(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K,Shide: Classification of diabetic nephropathy 2014, Jpn. J. Nephrol., 56:547-552, 2014 (inJapanese) .

7340C025(Joint committee on diabetes nephropathy), M.Haneda, K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino,
K.Kimura, Y.Suzuki, T.Wada, S.Ogawa, M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda,
K.Ichikawa, K.Shide: Classification of diabetic nephropathy 2014, The Journal of Metabolism and Clinical Nutrition,
17:325-330, 2014 (in Japanese) .

Short Communications
7340E001

K.Kanasaki, A.Maeshima, G.Taduri, I.Revuelta: Combating kidney fibrosis, Biomed Res Int., 2014:679154;1-2,
2014.

Others
7340F001

D.Koya: Dual protein kinase C alpha and beta inhibitors and diabetic kidney disease: a revisited therapeutic target
for future clinical trials, J Diabetes Investig, 5:147-148, 2014.

7340F002(T.Gohda), A.Mima, JY.Moon, K.Kanasaki: Combat diabetic nephropathy: from pathogenesis to treatment, J
Diabetes Res., 2014:207140;1-2, 2014.

7340F005

M.Kitada: Elucidation of the mechanisms of diabetic nephropathy, Diabetic Complications, 28:155-163, 2014 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
7340H001

K.Kanasaki: Workshop1 Pathophysiology of PE: I Pathogenesis of preeclampsia: COMT deficiency and relevans,
The 46th International Congress on Pathophysiology of Pregnancy, (Tokyo, '14.09).

7340H002

D.Koya: Symposium7 Aging and metabolism Metabolic changes in aging Nutrient sensing and metabolic health,2014 International Conference on Diabetes and Metabolism, (Gyeonggido, '14.10)，2014 International Conference
on Diabetes and Metabolism abstract book, 65, 2014.

－ 117 －

International Conference (Presentations)
7340I001

K.Konishi, S.Nakano, H.Ito, S.Tsuda, M.Kitada, K.Kanasaki, M.Nishizawa, A.Nakagawa, D.Koya: AST-120
ameliorates vascular endothelial dysfunctions and atherosclerosis in type 2 diabetic subjects with overt
nephropathy, The 8th International Congress on Uremia Research and Toxicity, (Okinawa, '14.03)，The 8thInternational Congress on Uremia Research and Toxicity Program and Abstract, 90, 2014.

7340I002

S.Shi, M.Kanasaki, T.Nagai, SP.Srivastava, K.Kanasaki, D.Koya: Linagliptin-mediated DPP-4 inhibition
ameliorates kidney fibrosis and endothelial-to-mesenchymal transition in streptozotocin-induced diabetic mice inassociated with restration of microRNA 29s, The 14th Asian Pacific Congress of Nephrology 2014, (Tokyo,'14.05)，Nephrology, 19:(Suppl.S2) 44, 2014.

7340I003

K.Kanasaki, M.Kanasaki, S.Shi, SP.Srivastava, D.Koya: Linagliptin-mediated DPP-4 inhibition ameliorates kidney
fibrosis in streptozotocin-induced diabetic mice via restoring microRNA29s, American Diabetes Association 74rd
Scientific Sessions, (San Francisco, '14.06).

7340I004(N.Ueki), S.Takeda, D.Koya, K.Kanasaki: Deficiency in catechol-o-methyltransferase is associated with glucose
intolerance, The 46th International Congress on Pathophysiology of Pregnancy, (Tokyo, '14.09)，Abstracts for the
46th International Congress on Pathophysiology of Pregnancy, 90, 2014.

7340I005

K.Kanasaki, SP.Srivastava, D.Koya: The antifibrotic microRNA crosstalk in the action of N-acetyl-seryl-aspartyllysyl-proline, Cell Symposia: Regulatory RNAs 2014, (Berkeley, '14.10).

7340I006

D.Koya, K.Kanasaki, M.Kitada: The antifibrotic microRNA crosstalk in the action of N-acetyl-seryl-aspartyllysyl-proline, The 10th International Diabetes Federation-Western Pacific Region Congress / 6th the Asian
Association for the Study of Diabetes, (Singapore, '14.11)，Diabetes Res. Clin. Pract. Suppl., 106:(Suppl.1) S123124, 2014.

－ 118 －

7400

Core Facility Center

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

NAKAMURA Akira

Immunology

Publications
Originals
7400B001

X.Zhao, A.Nogawa, T.Matsunaga, T.Takegami, H.Nakagawa, Y.Ishigaki: Proteasome inhibitors and knockdown of
SMG1 cause accumulation of Upf1 and Upf2 in human cells., Int. J. Oncol., 44:222-228, 2014.

7400B002(C.J.Treda), T.Fukuhara, T.Suzuki, A.Nakamura, J.Zaini, T.Kikuchi, M.Ebina, T.Nukiwa: Secretory leukocyte
protease inhibitor modulates urethane-induced lung carcinogenesis, Carcinogenesis., 35: 896-904, 2014.

7400B003

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, T.Kido, T.Kido, Y.Naruse,
Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-year risk fortype 2 diabetes mellitus in middle-aged Japanese men, Eur. J. Nutr., 53:251-258, 2014.

7400B004

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

7400B005(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

7400B006

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

7400B007

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

7400B008

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

7400B009

M.Nishijo, Y.Suwazono, W.Ruangyuttikarn, K.Nambunmee, W.Swaddiwudhipong, K.Nogawa, H.Nakagawa: Risk
assessment for Thai population: benchmark dose of urinary and blood cadmium levels for renal effects by hybrid
approach of inhabitants living in polluted and non-polluted areas in Thailand, BMC Public Health, 14:702;1-9,
2014.

7400B010

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

7400B011

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

－ 119 －

7400B012(Emerging Risk Factors Collaboration), H.Nakagawa, M.Sakurai, K.Nakamura, Y.Morikawa, et al.: Glycatedhemoglobin measurement and prediction of cardiovascular disease., JAMA, 311:1225-1233, 2014.

7400B013(K.Asayama), M.Satoh, Y.Murakami, T.Ohkubo, SY.Nagasawa, I.Tsuji, T.Nakayama, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura, Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCHJAPAN) Research Group, H.Nakagawa, et al.: Cardiovascular risk with and without antihypertensive drug
treatment in the Japanese general population: participant-level meta-analysis., Hypertension, 63:1189-1197, 2014.

7400B014

H.Shiga, J.Yamamoto, M.Kitamura, H.Nakagawa, T.Matsubasa, A.Seo, T.Miwa: Combinations of two odorants ofsmell identification test for screening of olfactory impairment., Auris Nasus Larynx, 41:523-527, 2014.

7400B015(T.Hisamatsu), K.Miura, T.Ohkubo, T.Yamamoto, A.Fujiyoshi, N.Miyagawa, A.Kadota, N. Takashima, N.Okuda,
K. Yoshita, Y.Kita, Y.Murakami, Y.Nakamura, T.Okamura, M.Horie, A.Okayama, H.Ueshima, NIPPON DATA80
Research Group, H.Nakagawa, et al.: High long-chain n-3 fatty acid intake attenuates the effect of high restingheart rate on cardiovascular mortality risk: a 24-year follow-up of Japanese general population., J. Cardiol.,
64:218-224, 2014.

7400B016(N.Okuda), J.Stamler, IJ. Brown, H.Ueshima, K.Miura, A.Okayama, S.Saitoh, H.Nakagawa, K.Sakata, K.Yoshita,
L.Zhao, P.Elliott, the INTERMAP Research Group: Individual efforts to reduce salt intake in China, Japan, UK,
USA: what did people achieve? The INTERMAP population study., J. Hypertens., 32:2385-2392, 2014.

7400B017(TV.Pereira), L.Kimura, Y.Suwazono, H.Nakagawa, M.Daimon, T.Oizumi, T,Kayama, T.Kato, L.Li, S.Chen, D.Gu,
W.Renner, W.März, Y.Yamada, PG.Bagos, RC.Mingroni-Netto: Multivariate meta-analysis of the association of Gprotein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes., Mol. Biol. Rep., 41:3113-3125, 2014.

7400B018

M.Nishijo, PT.Tai, TNA.Nguyen, TN.Nghi, H.Nakagawa, HV,Luong, AH.Tran, Y.Morikawa, HD.Manh, T.Kido,
MN.Nui, NM.Hai, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-yearold children in Vietnam., Mol. Psychiatry., 19:1220-1226, 2014.

7400B019(T.Kido), TV.Dao, MD.Ho, ND.Dang, NT.Pham, R.Okamoto, TT.Pham, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, SK.Le, HN.Nguyen: High cortisol and cortisone levels are associated with breast milk dioxin
concentrations in Vietnamese women., Eur. J. Endocrinol., 170:131-139, 2014.

7400B020(HD.Manh), T.Kido, R.Okamoto, S.Xianliang, Le T.Anh, S.Supratman, S.Maruzeni, M.Nishijo, H.Nakagawa,S.Honma, T.Nakano, T.Takasuga, DD.Nhu, NN. Hung, LK.Son: Serum dioxin levels in vietnamese men more than
40 years after herbicide spraying., Environ. Sci. Technol., 48:3496-3503, 2014.

7400B021(H.Suzuki), T.Kido, R.Okamoto, DD.Nhu, M.Nishijo, H.Nakagawa, K.Tawara, H.Horikawa, Y.Sato, PT.Dung,
LH.Thom, NN.Hung: The relationship between dioxin congeners in the breast milk of Vietnamese women and sister
chromatid exchange., Int. J. Mol. Sci., 15:7485-7499, 2014.

7400B022(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa: Impact of urinary
cadmium on mortality in the Japanese general population in cadmium non-polluted areas., Int. J. Hyg. Environ.
Health., 217:807-812, 2014.

7400B023(T.Inohara), S.Kohsaka, T.Okamura, M.Watanabe, Y.Nakamura, A.Higashiyama, A.Kadota, N.Okuda, Y.Murakami,
T.Ohkubo, K.Miura, A.Okayama, H.Ueshima, the NIPPON DATA 80/90 Research Group, H.Nakagawa, et al.:Cumulative impact of axial, structural, and repolarization ECG findings on long-term cardiovascular mortality
among healthy individuals in Japan: National Integrated Project for prospective observation of Non-Communicabledisease and its trends in the aged, 1980 and 1990., Eur J Prev Cardiol., 21:1501-1508, 2014.

7400B024(N.Miyagawa), K.Miura, N.Okuda, T.Kadowaki, N.Takashima, SY.Nagasawa, Y.Nakamura, Y.Matsumura,
A.Hozawa, A.Fujiyoshi, T.Hisamatsu, K.Yoshita, A.Sekikawa, T.Ohkubo, RD.Abbott, T.Okamura, A.Okayama,
H.Ueshima, the NIPPON DATA80 Research Group, H.Nakagawa, et al.: Long-chain n-3 polyunsaturated fatty
acids intake and cardiovascular disease mortality risk in Japanese: A 24-year follow-up of NIPPON DATA80,
Atherosclerosis, 232:384-389, 2014.

7400B025(Y.Kanari), A.Sugahara-Tobinai, H.Takahashi, M.Inui, A.Nakamura, S.Hirose, T.Takai: Dichotomy in FcγRIIB
deficiency and autoimmune-prone SLAM haplotype clarifies the roles of the Fc receptor in development ofautoantibodies and glomerulonephritis, BMC Immunol., 15:47;1-13, 2014.

－ 120 －

7400B026(T.Koyama), K.Yoshita, Y.Arai, K.Nakamura, M.Sakurai, M.Nishijo, SY.Nagasawa, Y.Morikawa, M.Tabata,
H.Nakagawa: Relationship between daily intake frequency of meals including a staple food,a main dish and a sidedish and nutrient intake in independent elderly individuals, Journal of Japanese Society of Nutrition and Food
Science., 67:299-305, 2014 (in Japanese) .

Others
7400F001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,, Y.
Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-yearrisk for type 2 diabetes mellitus in middle-aged Japanese men., Eur. J. Nutr., 53:1137-1138, 2014.

Presentations at Conference
International Conference (Presentations)
7400I001

M.Nishijo, PT.Tai, TN.Nghi, NTN.Anh, H.Nakagawa, S.Maruzeni, HV.Luong, TH.Anh, NV.Trung, PT.Phuong, LK.
Son, T.Kido, Y.Morikawa, H.Nishijo: Effects of dioxin exposure on neurodevelopment and urinary amino acidexcretion of children in exposed areas of Vietnam., The 34th international Symposium on Halogenated Persistent
Organic pollutants-Dioxin 2014, (Madrid, '14.08).

7400I002

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, T.Kido, T.Waseda, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-pdioxin in breast milk increases autistic traits of 3-year-old children in Vietnam., The 3rd International Conferenceof Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

7400I003

TN.Nghi, HD.Manh, PT.Tai, M.Nishijo, H.Nakagawa, T.Kido, H.Nishijo: Dioxins and nonorthor polychlorinatedbiphenyl concentrations in breast milk of Vietnamese nursing mothers living in the largest hot spot of dioxin
contamination., The 3rd International Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok,'14.11).

7400I004(PT.Tai), M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Luong, TH.Anh, TN.Nghi, Y.Morikawa, T.Kido,
H.Nishijo: Dioxin effects on infant development from newborn until 3 years of age., The 3rd International
Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

－ 121 －

Schoolof

Nursing8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing

Associate Professor

SAKAI Keiko

Communication Skills

Associate Professor

MATSUI Yuko

Nursing skill

Senior Assistant Professor

SUGIMORI Chiyoko

Nursing Education, fall risk management

Assistant Professor

OKAYAMA Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireResearch Associate

KOBATA Shizuka

fall risk management

Keywords of Researchfundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care

Outline of Research
1. Verification of nursing skills
3. Study of nursing education

Publications
Originals
8010B002(N.Nishio), Y.Matsui, A.Kitagawa, J.Sugama, H.Sanada: Changes in skin characteristics from the time of allogeneic
hematopoietic stem cell transplantation, J. Jpn. WOCM, 18:9-19, 2014 (in Japanese) .

8010B003

Y.Matsui, R.Murayama, H.Tanabe, M.Oe, M.Fukuda, Y.Motoo, T.Wagatsuma, S.Kinoshita, K.Sakai, C.Konya,
J.Sugama, H.Sanada: Analysis of thermographic images in an extravasation model of intravenous infusion in healthy
adults, Journal of Nursing Science and Engineering, 1:4-11, 2014 (in Japanese) .

Short Communications
8010E002(K.Aoki), Y.Matsui, A.Kitagawa, J.Sugama, H.Sanada: Morphological characteristics and healing process ofpressure ulcers in terminal cancer patients and identification of worsening factors, J. Jpn. WOCM, 17:294-303,
2014 (in Japanese) .

－ 122 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

MURAKADO Naoko

Chronic nursing，Diabetes nursing

Senior Assistant Professor

KINOSHITA Sachiko

Wound Care, Stoma care, Continence care

Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

ASANO Kimi

Wound Care

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001(Y.Ichikawa-Shigeta), J.Sugama, H.Sanada, T.Nakatani, C.Konya, G.Nakagami, T.Minematsu, S.Yusuf, Supriadi,
Y.Mugita: Physiological and appearance characteristics of skin maceration in elderly women with incontinence, J.
Wound Care, 23:18-19,22-23,26, 2014.

8040B002(S.Iizaka), M.Asada, H.Koyanagi, S.Sakaki, A.Naito, C.Konya, H.Sanada: The reliability and validity of color
inicators using digital image analysis of peristomal skin photographs: results of a preliminary prospective clinicalstudy, Ostomy Wound Manage., 60:12-29, 2014.

8040B003(Y.Ichikawa-Shigeta), H.Sanada, C.Konya, S.Yusuf, Supriadi, J.Sugama: Risk assessment tool for incontinenceassociated dermatitis in elderly patients combining tissue tolerance and perineal environment predictors: aprospective clinical study., Chronic Wound Care Management and Research., 1:41–47, 2014.

8040B004

Y.Matsui, R.Murayama, H.Tanabe, M.Oe, M.Fukuda, Y.Motoo, T.Wagatsuma, S.Kinoshita, K.Sakai, C.Konya,
J.Sugama, H.Sanada: Analysis of thermographic images in an extravasation model of intravenous infusion in healthy
adults, Journal of Nursing Science and Engineering, 1:4-11, 2014 (in Japanese) .

－ 123 －

8050

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Professor

HIRAMATSU Tomoko community/elderly nursing science

Associate Professor

KOIZUMI Yumi

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8050B001

O.Iritani, Y.Koizumi, Y.Hamazaki, H.Yano, T.Morita, T.Himeno, T.Okuno, M.Okuro, K.Iwai, S.Morimoto:
Association between blood pressure and disability-free survival among community-dwelling elderly patients
receiving antihypertensive treatment, Hypertens. Res., 37:772-778, 2014.

－ 124 －

8060

Pediatric Nursing

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

HASHI Shinobu

Single mother, asthma, child, belief, parenting stress

Assistant Professor

TERAI Takahiro

Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention－ 125 －

8070

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

YANAGIHARA
MachikoMatenity Nursing，Midwifery

Senior Assistant Professor

BODA Hitomi

Matenity Nursing，Midwifery

Senior Assistant Professor

IWATANI Kumiko

Matenity Nursing，Midwifery

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing

Research Associate

TAMURA Kana

Matenity Nursing，Midwifery

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8070B001

K.Iwatani, K.Shimada, Y.Fukumura: The perception of students towards the educational approach of clinicalinstructors during the maternity nursing clinical practicum:constructing a scale of students' perception andtendency of students' perception according to their background, J. Tsuruma Health Sci. Soc., 38:85-96, 2014.

－ 126 －

8080

Public Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Associate Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse

Associate Professor

SAKURAI Shihomi

Public health nursing, Family nursing

Assistant Professor

TONOYAMA Noriko

Public health nursing

School hygiene

Industrial health

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, activity of cmmunity organization, Nonsmoking education, School hygiene, Industrial health

Outline of Research
The community nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, and health maintenance.

Publications
Originals
8080B001

O.Iritani, Y.Koizumi, Y.Hamazaki, H.Yano, T.Morita, T.Himeno, T.Okuno, M.Okuro, K.Iwai, S.Morimoto:
Association between blood pressure and disability-free survival among community-dwelling elderly patients
receiving antihypertensive treatment, Hypertens. Res., 37:772-778, 2014.

8080B002

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

8080B003

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

8080B004

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

8080B005

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

8080B006

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

8080B007

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

－ 127 －

8080B008

S.Sakurai, Y.Kohno, M.Hirai: Chronic stress and sleep disorder in family caregivers living with frail elderly-A study
using indices of subjective evaluation,salivary cortisol,and secretory immunoglobulin A in saliva-, Journal of Japan
Academy of Home Care., 17:53-59, 2014 (in Japanese) .

－ 128 －

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Professor

HASEGAWA Masami

Senior Assistant Professor

TANAKA Koji

Senior Assistant Professor

NAGAYAMA Yutaka

Field of Specialization
depression, suicide prevention, therapeutic nursing, narrative
approachlife-world led care, patient-nurse interrelationship, empathy,
psychiatric and mental health nursing
Minimization for the action limitation, psychiatric nursing for acutephase

Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship,
empathy, psychiatric and mental health nursing, minimizing for the action limitation, physical restraint, seclusion, Emotion
Modulation Therapy

Outline of Research
The purpose of our study is to clarify the suicide prevention effect forthe depression people by Narrative approach and Emotion Modulation
Therapy(EMT). We are trｙing the effect of these methods as new
therapeutic nursing for depression people between our nursing clinic in
Japan and Griffth University clinic in Australia.

Publications
Originals
8085B001

K.Tanaka, M.Hasegawa: Narratives of a patient with chronic multiple psychiatric disorders and status of thepatient-nurse relationship: Achievement of rapport through the narrative approach, J. So. Nurs. Pract., 26:32-45,
2014.

8085B002

Y.Nagayama, M.Hasegawa: Nursing care process for releasing psychiatric inpatients from long-term seclusion in
Japan: Modified grounded theory approach, Nurs Health Sci., 16:284–290, 2014.

8085B003

K.Tanaka, M.Hasegawa: Recovery from depression in the elderly in relation to the life-world, Journal of Japan
Academy of Nursing Science., 34:1-10, 2014 (in Japanese) .

8085B005(M.Oe), M.Hasegawa, Y.Nagayama, K.Tanaka, S.Oe, K.Nakanishi, M.Kaneda, K.Morino, A.Fukutsuka,
H.Yamagata, K.Nagata, K.Kawamura: Psychiatric nurses’ distress in their care for patients with physicalcomplications, J. So. Nurs. Pract., 27:1-8, 2014 (in Japanese) .

8085B006(M.Oe), S.Tsukahara, Y.Nagayama, C.Nishimura: Acquisition ｐrocess of the ｍotivation to ｒemain in ｎursing
among ｎew ｇraduate ｎurses, Journal of Japan Academy of Nursing Science., 34:217-225, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8085I001

K.Tanaka, M.Hasegawa, Y.Toshikazu, Y.Nagayama, M.Oe: Structure of Psychiatric Nurse Empathy, 35th
International Association for Human Caring Conference, (Kyoto, '14.05).

－ 129 －

8085I002

Y.Nagayama, M.Hasegawa: Nursing care process for releasing psychiatric inpatients from long-term seclusion in
Japan, 35th International Association for Human Caring Conference, (Kyoto, '14.05).

8085I003

M.Hasegawa, M,Oe, K.Tanaka, Y.Nagayama: The efficacy of support groups for people with depression and thepossibility of self-help groups, 14th international forum on mood and anxiety disorders, (Vienna, '14.12).

－ 130 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
supportAssistant Professor

NAKAI Hisao

Home healthcare,Disaster Nursing,Care Management

Assistant Professor

FUKUDA Moriyoshi

Nursing care of pressure ulcer，Home care

Keywords of Research
Psychiatric Disorder, Community besed Workshop, "Recoverry"consept, psychatric service, Public health nursing
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced "Recoverry"consept, prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B002

Y.Matsui, R.Murayama, H.Tanabe, M.Oe, M.Fukuda, Y.Motoo, T.Wagatsuma, S.Kinoshita, K.Sakai, C.Konya,
J.Sugama, H.Sanada: Analysis of thermographic images in an extravasation model of intravenous infusion in healthy
adults, Journal of Nursing Science and Engineering, 1:4-11, 2014 (in Japanese) .

8090B004

S.Sakurai, Y.Kohno, M.Hirai: Chronic stress and sleep disorder in family caregivers living with frail elderly-A study
using indices of subjective evaluation,salivary cortisol,and secretory immunoglobulin A in saliva-, Journal of Japan
Academy of Home Care., 17:53-59, 2014 (in Japanese) .

Others
8090F001

H.Nakai, Y.Morishita: Awareness of disaster preparedness that takes physical condition into account amongindividuals requiring medical care, Journal of Japan Society of Disaster Nursing, 16:16-26, 2014 (in Japanese) .

－ 131 －

8095

Comprehensive Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing, Paliative Care, Chronic
Disease Nursing

Keywords of Researchnephrology, nursing, chronic kidney disease, hemodialysis
nursing, cancer survivors, care development
nursing, live donor, transplants

Outline of Research
Development of A Care for Cancer Survivors
Development of A Care for Live Donor for Transplants
Development of A Care for Patients under Chronic Kidney Disease or Hemodialysis

Publications
Originals
8095B002

S.Tamura: Experience perception by living donors who are mothers of patients in renal transplants, The Journal ofJapan Academy of Nephrology Nursing, 16:52-58, 2014 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8095I001

S.Tamura, K.Shintani: The necessity of nursing support for pain management seen from chronic phase cancer
survivors' pain and treatment, 18ｔｈ International Conference on Cancer Nursing, (Panama, '14.09)，2014.

8095I002(K.Shintani), S.Tamura: Current Situation and Issues for Self-Management of Breast Cancer Patients, 18ｔｈ
International Conference Cancer Nursing, (Panama, '14.09)，2014.

－ 132 －

8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Professor

HONDA Ryumon

Environment and health, Epidemiology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001

O.Iritani, Y.Koizumi, Y.Hamazaki, H.Yano, T.Morita, T.Himeno, T.Okuno, M.Okuro, K.Iwai, S.Morimoto:
Association between blood pressure and disability-free survival among community-dwelling elderly patients
receiving antihypertensive treatment, Hypertens. Res., 37:772-778, 2014.

8100B002(K.Sasaki), T.Sakai, T.Nagaoka, K.Wake, S.Watanabe, M.Kojima, N.Hasanova, H.Sasaki, K.Sasaki, Y.Suzuki,
M.Taki, Y.Kamimura, A.Hirata, H.Shirai: Dosimetry using a localized exposure system in the Millimeter-Waveband for in vivo studies on ocular effects, IEEE Trans. Microw. Theory Tech., 62:1554-1564, 2014.

8100B003

Y.Oka, M.Rahman, C.Sasakura, T.Waseda, Y.Watanabe, R.Fujii, S.Makinoda: Prenatal diagnosis of fetal
respiratory function: evaluation of fetal lung maturity using lung-to-liver signal intensity ratio at magnetic
resonance imaging, Prenat. Diagn., 34:1289-1294, 2014.

8100B004

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, T.Kido, T.Kido, Y.Naruse,
Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-year risk fortype 2 diabetes mellitus in middle-aged Japanese men, Eur. J. Nutr., 53:251-258, 2014.

8100B005

Y.Morikawa, K.Nakamura, M.Sakurai, SY.Nagasawa, M.Ishizaki, M.Nakashima, T.Kido, Y.Naruse, H.Nakagawa:
The effect of age on the relationships between work-related factors and heavy drinking, J. Occup. Health, 56:141149, 2014.

－ 133 －

8100B006(D.Suvagandha), M.Nishijo, W.Swaddiwudhipong, R.Honda, M.Ohse, T.Kuhara, H.Nakagawa, W.Ruangyuttikarn: A
biomarker found in cadmium exposed residents of Thailand by metabolome analysis, Int J Environ Res Public
Health., 11:3661-3677, 2014.

8100B007

S.Yoneyama, K.Nakamura, K.Nakamura, Y.Morikawa, K.Miura, M.Nakashima, K.Yoshita, M.Ishizaki, T.Kido,
Y.Naruse, K.Nogawa, Y.Suwazono, S.Sasaki, H.Nakagawa: Associations between rice, noodle, and bread intake andsleep quality in Japanese men and women, PLoS ONE, 9:e105198;1-11, 2014.

8100B008

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: HOMA-IR and the risk of hyperuricemia: a prospective study in nondiabetic Japanese men, Diabetes Res. Clin. Pract., 106:154-160, 2014.

8100B009

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, SY.Nagasawa, M.Ishizaki, T.Kido, Y.Naruse, M.Nakashima,
K.Nogawa, Y.Suwazono, H.Nakagawa: Overall sleep status and high sensitivity C-reactive protein: a prospective
study in Japanese factory workers, J. Sleep. Res., 23:717-727, 2014.

8100B010

M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, T.Takamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,
Y.Naruse, M.Nakashima, K.Nogawa, Y.Suwazono, H.Nakagawa: Association between a serum thyroid-stimulating
hormone concentration within the normal range and indices of obesity in Japanese men and women., Intern. Med.,
53:669-674, 2014.

8100B011

S.Maruzeni, M.Nishijo, K.Nakamura, Y.Morikawa, M.Sakurai, M.Nakashima, T.Kido, R.Okamoto, K.Nogawa,Y.Suwazono, H.Nakagawa: Mortality and causes of deaths of inhabitants with renal dysfunction induced by cadmium
exposure of the polluted Jinzu River basin, Toyama, Japan; a 26-year follow-up., Environ Health., 13:18;1-12,
2014.

8100B012(Emerging Risk Factors Collaboration), H.Nakagawa, M.Sakurai, K.Nakamura, Y.Morikawa, et al.: Glycatedhemoglobin measurement and prediction of cardiovascular disease., JAMA, 311:1225-1233, 2014.

8100B013

M.Nishijo, PT.Tai, TNA.Nguyen, TN.Nghi, H.Nakagawa, HV,Luong, AH.Tran, Y.Morikawa, HD.Manh, T.Kido,
MN.Nui, NM.Hai, H.Nishijo: 2,3,7,8-tetrachlorodibenzo-p-dioxin in breast milk increases autistic traits of 3-yearold children in Vietnam., Mol. Psychiatry., 19:1220-1226, 2014.

8100B014(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa: Impact of urinary
cadmium on mortality in the Japanese general population in cadmium non-polluted areas., Int. J. Hyg. Environ.
Health., 217:807-812, 2014.

8100B015(T.Koyama), K.Yoshita, Y.Arai, K.Nakamura, M.Sakurai, M.Nishijo, SY.Nagasawa, Y.Morikawa, M.Tabata,
H.Nakagawa: Relationship between daily intake frequency of meals including a staple food,a main dish and a sidedish and nutrient intake in independent elderly individuals, Journal of Japanese Society of Nutrition and Food
Science., 67:299-305, 2014 (in Japanese) .

Reviews
8100C001

Y.Morikawa: The issue of sleep as a risk for occupational safety, Hokuriku Japanese Journal of Public Health.,
40:17-23, 2014 (in Japanese) .

Others
8100F001

M.Sakurai, K.Nakamura, K.Miura, T.Takamura, K.Yoshita, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido,, Y.
Naruse, Y.Suwazono, S.Sasaki, H.Nakagawa: Sugar-sweetened beverage and diet soda consumption and the 7-yearrisk for type 2 diabetes mellitus in middle-aged Japanese men., Eur. J. Nutr., 53:1137-1138, 2014.

Presentations at Conference
International Conference (Presentations)
8100I001

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki: Lens damage
induced by 40 GHz millimeter wave, International Conference on the Lens, (Hawaii, '14.01).

－ 134 －

8100I002(J.Chakarothai), M.Kojima, Kensuke Sasaki, K.Wake, Y.Suzuki, M.Taki, S.Watanabe: Millimeter-wave power
absorbed into rabbit eye due to different exposure environments, EMC2014, (Tokyo, '14.05).

8100I003

M.Kojima, CY.Tsai, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, M.Taki, K.Sasaki,
H.Sasaki: Millimeter wave exposure induces cornea and lens epithelium damage, BioEM2014, (Cape Town, '14.06).

8100I004

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: 75 GHz millimeter wave exposure to eye: role of environment factors in effects, BioEM2014, (CapeTown, '14.06).

8100I005

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki: Effect of relative Humidity during 40 GHz millimeter wave exposure, 31th URSI General Assembly and
Scientific Symposium, (Beijing, '14.08).

8100I006

M.Nishijo, PT.Tai, TN.Nghi, NTN.Anh, H.Nakagawa, S.Maruzeni, HV.Luong, TH.Anh, NV.Trung, PT.Phuong, LK.
Son, T.Kido, Y.Morikawa, H.Nishijo: Effects of dioxin exposure on neurodevelopment and urinary amino acidexcretion of children in exposed areas of Vietnam., The 34th international Symposium on Halogenated Persistent
Organic pollutants-Dioxin 2014, (Madrid, '14.08).

8100I007

M.Kojima, CY.Tsai, T.Okuno, K.Sasaki, K.Sasaki, H.Sasaki: Ocular temperature measurements during infrared or
millieter wave exposure, 39th International Conference on Infrared, Millimeter, and THz Waves, (Tucson, '14.09).

8100I008

K.Iwai, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF regulates the formationof apoptosis by conjugating the two opposite pathways in arterial smooth muscle cell, European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35 (Suppl.) ：612-613, 2014.

8100I009

K.Iwai, T.Okuno, T.Morita, H.Yano, O.Iritani, M.Okuro, S.Morimoto, Y.Nakamura, Y.Ishigaki: CTCF isprerequisite for the fetal gene expression in the process of hypertrophy of the cardiomyocyte., European Society ofCardiology Congress 2014, (Barcelona, '14.09)，European Heart Journal, 35：(Suppl.) 954-955, 2014.

8100I010

CY.Tsai, M.Kojima, Y.Suzuki, Kensuke Sasaki, K.Sasaki, H.Sasaki: Effects of environmental factors during
millimeter wave exposure, 13th Congress of the International Society of Ocular Toxicology, (Kanazawa, '14.10).

8100I011(PT.Tai), M.Nishijo, H.Nakagawa, S.Maruzeni, NTN.Anh, HV.Luong, TH.Anh, TN.Nghi, Y.Morikawa, T.Kido,
H.Nishijo: Dioxin effects on infant development from newborn until 3 years of age., The 3rd International
Conference of Asian Environmental Chemistry,ICAEC 2014, (Bangkok, '14.11).

8100I012

K.Iwai, T.Okuno, T.Morita, O.Iritani, M.Okuro, S.Morimoto: Nucleostemin and Nucleophosmin Express with Upregulating Telomere Reverse Transcriptase in the Arteriosclerotic Lesions, Scientific Sessions 2014, American
Heart Association, (Chicago, '14.11)，Circulation, 130(Suppl)：A17204, 2014.

－ 135 －

Department of General Education

8610

Natural Sciences

Faculty
Title

Name

Field of Specialization

Professor

TANAKA Ichiro

Scientific sociology, History of technology

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Associate Professor

HASHIMOTO
Mitsumasa

Radiation Biology, Cell Biology

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

INOUE Tomoki

Graph theory in toplogy

Assistant Professor

OKUDA Koichi

Fixed-quantity rating system in the heart nuclear medicine

Keywords of Research
Bertrand curve,, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,,
Mannheim curve, Frenet frame, graph theory in topology, topological polyhedron
Nuclear medicine,, Nuclear cardiology, Imaging, Image processing,, SPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing
Radiation, DNA double strand breaks (DSBs)
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)
history of science,

history of technology,, Galileo Galilei,, Isaac Newton,, Venetian patent law

ultrastructure, pharynx,, sponge,, metamorphosis, immunoelectron microscopy, neurosynaps,, neurosecretory cell, lectin,
galectin,, β-galactoside, Xenopus,, development, placenta

Outline of Research"Hashimoto:Function of DNA repair enzymes, especially protection mechanisms against DNA double strand breaks induced
ionizing radiation
Okuda:The aim of our research is to develop a computer algorithm for thequantitative assessment of myocardial perfusion and sympathetic nerve
activity in the nuclear cardiology.""Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Inoue:We extend the Graph Theory, and define a topologicalpolyhedron which coverd on closed surface of genus g. We give
characterizations and example of the topological polyhedron.""１）Functional analysis of Galectins, a family of F-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
"
MAEDA:"Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies
have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to abetter treatment for cancer."－ 136 －TANAKA:The research theme is the history of early modern science and technology. The topics being studied include
Galileo Galilei and Venetian Patent Law enacted in 15th century.

Publications
Originals
8610B001

K.Okuda, K.Nakajima, M.Yamada, H.Wakabayashi, H.Ichikawa, H.Arai, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya:
Optimization of iterative reconstruction parameters with attenuation correction, scatter correction and resolution
recovery in myocardial perfusion SPECT/CT., Ann. Nucl. Med., 28:60-68, 2014.

8610B002

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, K.Iwabuchi, N.Tomosugi: RNA-binding protein RBM8A (Y14)and MAGOH localize to centrosome in human A549 cells., Histochem. Cell Biol., 141:101-109, 2014.

8610B003(K.Nakajima), K.Okuda, M.Yoshimura, S.Matsuo, H.Wakabayashi, Y.Imanishi, S.Kinuya: Multicenter crosscalibration of I-123 metaiodobenzylguanidine heart-to-mediastinum ratios to overcome camera-collimator
variations, J. Nucl. Cardiol., 21:970-978, 2014.

Reviews
8610C001

T.Arikawa, E.Simamura, H.Shimada, T.Nakamura, T.Hatta, H.Shoji: Significance of sugar chain recognition by
galectins and its involvement in disease-associated glycosylation, Congenit. Anom. (Kyoto), 54:77-81, 2014.

Presentations at Conference
International Conference (Presentations)
8610I001

K.Okuda, K. Nakajima, Y.Kirihara, S.Sugino, S.Matsuo, J. Taki, M.Hashimoto, S.Kinuya: Proposal forstandardization of cardiac 123I-metaiodobenzylguanidine washout rate., 11th WFNMB, (Cancun, '14.08).

8610I002(T.Konishi), M.Onoguchi, K.Nakajima, S.Matsuo, H. Wakabayashi, R.Hunayama, K.Okuda, Y.Matsuura: Clinicalstudy to evaluate the performance and impact of attenuation and scatter correction in 201TlCl myocardial
perfusion SPECT using a SMARTZOO Mcollimator., 11th WFNMB, (Cancun, '14.08).

8610I003(S.Matsuo), K.Nakajima, M.Yamagishi, H.Wakabayashi, K.Okuda, S.Kinuya: Apical Metabolic Abnormalities is oneof the typical features of Takotsubo Cardiomyopathy., 11th WFNMB, (Cancun, '14.08).

8610I004(H.Shiga), J.Taki, K.Okuda, N.Watanabe, H.Tonami, S.Kinuya, M.Furukawa,, T.Miwa: Assessment of peripheral
olfactory nerve image in patients with idiopathic olfactory impairments in comparison to healthy volunteers.,
European Chemoreception Research Organization, (Dijon, '14.09).

8610I005

Y.Ishigaki, Y.Nakamura, T.Tatsuno, M.Hashimoto, T.Shimasaki, K.Iwabuchi, N.Tomosugi: Role of RNA binding
protein in cell cycle progression and centrosome maturation in human tumor cells., 19th World Congress on
Advances in Oncology & 17th International Symposium of Molecular Medicine, (Greece, '14.10).

8610I006(K. Nakajima), K.Okuda, M. Yoshimura, S. Matsuo, H. Wakabayashi, Y. Imanishi, S. Kinuya: Proposal to unify
MIBG heart-to-mediastinum ratio using a cross-calibration phantom method: Multi-centre experiments and aclinical validation study., 27th Annual Congress of the European Association of Nuclear Medicine, (Gothenburg,'14.10).

8610I007

M.Hashimoto: Analysis of the interaction between 53BP1 and Rad18 for Telomere Ends Fusion, 15thIUBMB,(taipei, '14.10).

8610I008

R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi: Ubiquitin-dependent activation of DNA-PKcs in
response to DNA replication-mediated DNA double strand breaks, The 9th 3R Symposium Together with National
Institute of Genetics 2014 International Symposium, (Gotenba, '14.11)，Abstracts, 105, 2014.

－ 137 －

8620

Human Sciences

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

TAKEDA Koichi

Philosophy, History of logic

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Senior Assistant Professor

HONDA Kojiro

Ethics of technology

Senior Assistant Professor

IKENAKA Masami

English Education

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research,, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical English,, elearning
end of the century, culture, the middle Ages, Modern times, Europe
exercise prescription, lifestyle-related diseases, improvement of physical fitness, soccer, PE classlogic, metaphysics, form, content, predicate, category, deduction, induction, matter,, being, substance, definion,
Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics,
Cognitive Science of Learning, History of Science, Philosophy of Science

Outline of Research"Hara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many
prominent intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field ofliterature. He almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern
Europe. I analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in theGerman-language area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen""Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons.
In addition, our research focuses on improvement of physical fitness through soccer in PE classes for children.""Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
Burke:My most recent research interest has been the connection and power that extensive reading has on English－ 138 －

acquisition for EFL students.
Woods:Using computer software for natural language processing of the
English found in medical articles to determine the most commonly used
words, forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.""TAKEDA:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.
HONDA:It is inquiring about the ethics of technology.
""Tradition of knowledge"" has considered the problem what kind of responsibility occurs why in possible one and the sidewhich inherits knowledge again, by the mainly phenomenological technique."

Publications
Originals
8620B001(K.Saito), K.Yamaguchi, R.Tsuda: A study of performance in basketball games : focusing on games with a change innumber of player, Hiroshima Journal of School education, 20:103-108, 2014 (in Japanese) .

8620B002(M.Hirashita), Y.Nho, S.Omori, K.Miyaguchi, R.Tsuda, T.Murayama: Investigation of physical activity level andmotor ability in early childhood in ishikawa prefecture, The Journal of Kanazawa Gakuin University, 20:139-145,
2014 (in Japanese) .

8620B003

R.Tsuda, A.Inoue, K.Suzuki, K.Saito: The effect of the soccer class taking into account improvement in physicalfitness:focusing on 8vs8 games with changes in pitch area, Football Sｃience, 11:29-38, 2014 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
8620H001

K.Honda: Developing a 'Charter of Roboethics'：from a retrospective to a proactive approach in robot techonology
engineering, "Roboethics" Technology Assessment and Responsible Innovation in Japan and Germany, (Berlin,'14.12).

International Conference (Presentations)
8620I001

K.Honda: Robots? Design and Ethics of Enhancement, Japanese-Dutch workshop in philosophy of technology,(Enschede, '14.06).

8620I002

R.Tsuda: The effect on physical fitness of changing pitch area per player in small-sided soccer games in PE classes,
19th annual Congress of the European College of Sport Science, (Amsterdam, '14.07).

8620I003

K.Honda: Robotics and Ethics of Enhancement, The 9th International Conference on Applied Ethics, (Sapporo,'14.11).

－ 139 －

AffiliatedInstitution

9030

Northerm Noto Institute for Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Keywords of Research
The Elderly, Rural Medicine, Medical Needs

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

－ 140 －

9050

Center for FDD-MB

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's
health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology

Presentations at Conference
International Conference (Key Note Lecture)
9050G001

H.Takabayashi, M.Kita: Prenatal Diagnosis using fetal cell, Fetal DNA Diagnosis in Maternal Blood World Wide
Researcher Congress and Prenatal Diagnosis, (Jakarta, '14.01).

9050G002

H.Takabayashi: Prenatal Diagnosis using Fetal Cells _by FDD-MB System, 12th Congress of the Indian Society for
Prenatal Diagnosis and Therapy (ISPAT), (Mumbai, '14.09).

－ 141 －

Himi

Municipal

Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

FUKUDA Akihiro

Cardiology

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

MORIYAMA Manabu

Kidney transplantation，Urolithiasis

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Professor

MATSUKI Nobuo

Oncology Surgery

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

IGUCHI Masaharu

Respiratory Medicine

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

KUZAWA Yutaka

Cardio Vascular Surgery

Associate Professor

IKEBUCHI Kimihiro

Orthopaedic Surgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

ASANO Masamitsu

Cardiology

Senior Assistant Professor

KIYOSAWA Jun

Cardiology

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

AOKI Nobuyuki

Orthopaedic Surgery

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies

Assistant Professor

MIZUNO Takuro

Cardiology

Assistant Professor

HIGASHIKAWA
Toshihiro

Gerontology

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

NAKAMURA Kisuke

Oncology Surgery

Assistant Professor

SAKAMOTO Daisuke Cardiovascular Surgery

Assistant Professor

ARISAWA Akiko

Orthopaedic Surgery

Assistant Professor

KUSABA Eizo

neurosurgery

Publications
Originals
9100B001

M.Matoba, H.Tsuji, Y.Shimode, I.Toyota, Y.Kuginuki, T.Miwa, H.Tonami: Fractional change in apparent diffusion
coefficient as an imaging biomarker for predicting treatment response in head and neck cancer treated withchemoradiotherapy, AJNR Am J Neuroradiol., 35:379-385, 2014.

－ 142 －

9100B002

K.Usuda, M.Sagawa, N.Motono, M.Ueno, M.Tanaka, Y.Machida, S.Maeda, M.Matoba, Y.Kuginuki, M.Taniguchi,
H.Tonami, Y.Ueda, T.Sakuma: Diagnostic performance of diffusion weighted imaging of malignant and benign
pulmonary nodules and masses: comparison with positron emission tomography, Asian Pac. J. Cancer Prev.,
15:4629-4635, 2014.

Case Reports
9100D001

T.Mizuno, K.Ishigami, S.Yamada, H.Tsuchiya, C.Nakajima, R.Sangen, M.Fukushima, H.Minato, T.Nojima, A.Saito,
N.Hayashi, H.Atsumi, T.Ito, M.Iguchi, D.Usuda, H.Okamura, S.Urashima, M.Asano, J.Kiyosawa, A.Fukuda,
N.Takekoshi, T.Kanda: Endocardial invasion of lung cancer undiagnosable before autopsy, Case Rep Oncol.,7:144-148, 2014.

9100D002(K.Kaneko), Y.Matsuta, M.Moriyama, M.Yasuda, N.Chishima, N.Yamaoka, T.Fukuuchi, K.Miyazawa, K.Suzuki:
Proteomic analysis of a rare urinary stone composed of calcium carbonate and calcium oxalate dihydrate： A casereport, Int. J. Urol., 21:341-346, 2014.

－ 143 －