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I
Code

Department

School

Page

D

E

X

Code

Department

Medicine

0250

Department of Legal Medicine ･･･････････････36

Arts

0260

Department of Medical Education ････････････37

ofLiberalN

0010

Department of Human Science (Humanities) ･･･1

0030

Department of Human Science (Mathematics) ･･20040

Department of Life Science

Clinical

Page

Medicine

0300

Department of Cardiovascular Medicine ･･･････38

0310

Department of Respirology (Respiratory Medicine)･40

Department of Life Science

0320

Department of Gastroenterology ･････････････42(Natural Science:Chemistry) ･･････････････････40330

Department of Nephrology ････････････････････44

Department of Life Science

0340

Department of Endocrinology and Metabolism･･･47(Natural Science:Biology) ･････････････････････50350

Department of Hematology and Immunology ･･･50

Department of Human Science

0360

Department of Neurology ･････････････････････52(Foreign Languages:English) ･･････････････････6

0370

Department of Geriatric Medicine･･････････････53

Department of Human Science

0380

Department of Pediatrics ･････････････････････55(Foreign Languages:German) ･･････････････････70390

Department of Neuropsychiatry ･･･････････････57

0090 Department of Life Science (Physical Education) ･･･80400

Department of Diagnostic and Therapeutic(Natural Science:Physics)
0050

0060

0070

0080

････････････････････3

Radiology ･･･････････････････････････････････59
0410

Department of Cardiovascular Surgery ･･････61

Department of Molecular and Cell Structural

0420

Department of Surgical Oncology ････････････63

Science (Anatomy Ⅰ) ････････････････････････90430

Department of Orthopedics Surgery ･･･････････65

Department of Molecular and Cell Structural

0440

Department of Neurosurgery ･････････････････67

Science (Anatomy Ⅱ) ････････････････････････100450

Department of Plastic and Reconstructive

Basic
0100

0110

0120

Medicine

Surgery ････････････････････････････････････70

Department of Physiology Ⅰ･･････････････････110130 Department of Physiology Ⅱ ･･････････････････13

0460

Department of Pediatric Surgery ･･････････････72

0140

Department of Biochemistry Ⅰ･･･････････････15

0470

Department of Ophthalmology ････････････････74

0150

Department of Biochemistry Ⅱ ･･････････････170480

Department of Otolaryngology ････････････････78

0160

Department of Pharmacology ････････････････190490

Department of Dermatology･･･････････････････80

0170

Department of Oncologic Pathology ･･････････20

0500

Department of Urogenital Surgery ････････････82

0180

Department of Pathophysiological and0510

Department of Obstetrics and Gynecology ･････84

Experimental Pathology ････････････････････240520

Department of Anesthesiology andPerioperative edicine ････････････････････････86

0190

Department of Microbiology ･････････････････26

0200

Department of Fundamental Research for CAM ･･27

0530

Department of Oral and Maxillofacial Surgery･･88

0210

Department of Medical Zoology･･･････････････28

0550

Department of Emergency Medicine････････････90

0220

Department of Pathology and Laboratory

0560

Department of Medical Oncology ･･････････････91

Medicine ･･･････････････････････････････････29

0610

Health Management Center･･････････････････93

Department of Social and Environmental

0620

Department of Pathology ･････････････････････96

Medicine ･･･････････････････････････････････31

0630

Department of General Internal Medicine ･･････97

0240 Department of Epidemiology and Public Health ･･･33

0640

Endoscopy Center ････････････････････････････99

0230

Code

Department

Page

0650

Department of Rehabilitation Medicine ･･･････100

0660

Department of Respirology (Thoracic Surgery) ･･101

0670

Lifestyle-related Diseases Center ････････････103

0680

Medical Genetic Center･･････････････････････104

0690

Department of Endoscopy････････････････････105

Schoolof

Nursing

8010

Basic Nursing ･････････････････････････････107

8030

Psychiatric and Mental Health Nursing･･･････108

8040

Adult Nursing

8050

Nursing of the Elderly ･･････････････････････110

8070

Maternity Nursing ･････････････････････････111

8080

Community Nursing･････････････････････111

8090

Home Care Nursing･･･････････････････････113

8100

Human Science

Medical････････････････････････････109････････････････････････114

Research

Institute

0740

Division of Human Genetics (Biochemistry) ･･119

0750

Division of Human Genetics (Clinical Medicine) ･120

0770

Division of Core Facility (Radioisotope Center) ･･121

0780

Division of Core Facility(Experimental Animal Center) ･･････････････122

0790

Division of Core Facility(Morphological Equipment Center) ･･････････123

0800

Division of Core Facility(High-Tech Research Center) ･･･････････････124

0900

Division of Cell Medicine ･･･････････････････126

0910

Division of Advanced Medicine ･･････････････127

0920

Division of Molecular Oncology and Virology ････129

0930

Division of Dermatomycology(Novartis Pharma) ･････････････････････････131

0970

Division of Vision Research forEnvironmental Health ･･････････････････････133

Code

Department

Page

School of Medicine

0010

Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

Professor

HIRAGUCHI Tetsuo

environmental-ethnoarchaeology， peace studies．

Associate Professor

TAKEDA Koichi

Philosophy , History of logic

Keywords of Researchzoo-archaeology, cetacean, dolphin, whale, faunal remains, environmental archaeology, whaling, ancient diet, Palaeolithic
period, Jomon period, ethno-archaeology, anthropological education, logic, metaphysics, form, content, predicate, category,
deduction, induction, matter, being, substance, definion

Outline of Research
Hiraguchi:Environmental and ethnological archaeology, especially prehistoric whaling, and anthropological education for
medical students.
Takeda:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

Publications
Originals
0010B001

K.Takeda: The logicians school of ancient chinese philosophy and ancient greek philosophers, Mem. Lib. Kanazawa
Med. Univ., 35:1-11, 2007 (in Japanese) .

Others0010F001

T.Hiraguchi: Participating in the traditional whaling summits: from the viewpoint of nine thousand years in whale
food culture, Reports and Proceedings: The 5th Summit of Japanese Traditional Whaling Communities (Institute of
Cetacean Research et al.), 63-70, 2007.

0010F002

T.Hiraguchi: The point view of cetacean archaeology, The world of cultural heritage., 24:4-9, 2007 (in Japanese) .

－ 1 －

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field

－ 2 －

0040

Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

Associate Professor

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex

Senior Assistant Professor

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Keywords of Researchpiriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording

Outline of Research
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: In order that the student who majors in life science may deepen an understanding of a lecture, and in order toenable independent learning, we are developing the stude support which used a demonstration experiment and intranet.

－ 3 －

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

Research Associate

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

Publications
Short Communications
0050E001

T.Ota, M.Maeda, M.Murakami, T.Takegami, S.Suto, M.Tatsuka: Activation of Rac1 by Rho-guanine nucleotide
dissociation inhibitor-β with defective isoprenyl-binding pocket, Cell Biol. Int., 31:92-96, 2007.

－ 4 －

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

Professor

HORI Isao

Development of ascidians

Associate Professor

ASAI Etsuo

Regeneration of planarians

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell

Outline of Research
It is well known that planarians have a strong power of regeneration. This power depends mainly on a large number ofundifferentiated stem cells or neoblasts which distribute through the parenchymal region of intact planarians. I have studied
differentiation,proliferation and morphogenesis of these neoblasts by using an electron microscope. Neoblasts are small insize and oval in shape. Their cytoplasm is occupied with free ribosomes and mitochondria. Synthetic organelles are notdeveloped. Most characteristic feature is several chromatoid bodies surrounding the nuclear envelope.
Their size and number reduce during cell differentiation. Formation of the chromatoid bodies is inhibited by actinomycin D.
These results suggest that chromatoid bodies relate to differentiation of neoblasts. I also studied the process ofmorphogenesis of muscle layers, gastrodermis and epidermis after decapitation. The data suggest that a kind of
neuropeptides and retinoic acid stimulate cell differentiation within the regeneration blastema.

Publications
Originals
0060B001(S.Higuchi), T.Hayashi, I.Hori, N.Shibata, H.Sakamoto, K.Agata: Characterization and categorization offluorescence activated cell sorted planarian stem cells by ultrastructural analysis, Dev. Growth Differ., 49:571581, 2007.

－ 5 －

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics，Phonetics

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works

Senior Assistant Professor

CURRY Carla

English education from a viewpoint of music

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation

Outline of Research
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
C.Curry: My research has focused on using music in the classroom to teach English pronunciation, rhythm, and tone.
Students can quickly grasp the main elements of English sound structures when illustrated through chants and songs. I am
also interested in how to teach phonics to students who do not use a language represented by a phonetic alphabet.
Therefore, I have been studying the various techniques for teaching English phonics to young learners in Japan.

Publications
Originals
0070B001

K.Kakizaki: Father’s legacy in 'A silver dish', Shlemiel., 6:16-28, 2007.

0070B002

K.Kakizaki: The journey through letters in Herzog, Journal of English Language and Literature, 55:109-126, 2007.

0070B003

K.Kakizaki: Spiritual awakening in “Leaving the yellow house”, Kanazawa English Studies, 26:1-13, 2007.

0070B004

K.Kakizaki: Mystery of love in "A father-to-be", Mem. Lib. Kanazawa Med. Univ., 35:13-22, 2007.

－ 6 －

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

Associate Professor

HARA Akira

Austria literature led by Hofmannsthal

Senior Assistant Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

－ 7 －

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

Associate Professor

YAMASHINA Tadahiko

Senior Assistant Professor

UEDA Fumio

Muscle Strength, Muscle Strength Training, Thickness of Muscles inthe Lower leg
Physical strength and a study about the athletic capability，Abasketball competition

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Yamashina : To find an effective way to prevent falling ,I have studied the ability to sustain a standing posture and fallingmechanism.
To clarify the association between antigravity muscles and the ability to sustain static and active standing posture.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.

Publications
Originals
0090B001

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

0090B002

T.Yamashina: The association between the thickness of muscles in the lower leg and walking, Mem. Lib. Kanazawa
Med. Univ., 35:23-30, 2007 (in Japanese) .

0090B003

F.Ueda, N.Tamura, T.Yamashina: A report on the physical fitness and motor ability of students at Kanazawa
Medical University(ⅩⅩⅩⅢ), Mem. Lib. Kanazawa Med. Univ., 35:31-38, 2007 (in Japanese) .

－ 8 －

0100

Department of Molecular and Cell Structural Science (Anatomy Ⅰ)

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Senior Assistant Professor

HIGASHI Nobuaki

macroscopic anatomy

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001

T.Hatta, F.Satow, J.Hatta, R.Hashimoto, J.Udagawa, A.Matsumoto, H.Otani: Development of the pons in humanfetuses, Congenit. Anom. (Kyoto), 47:63-67, 2007.

0100B002(H.Habib), T.Hatta, Omar Ibna Faizur Rahman, Y.Yoshimura, H.Otani: Fetal jaw movement affects development ofarticular disk in the temporomandibular joint, Congenit. Anom. (Kyoto), 47:53-57, 2007.

Reviews
0100C001(J.Udagawa), T.Hatta, R.Hasimoto, H.Otani: Roles of leptin in prenatal and perinatal brain development, Congenit.
Anom. (Kyoto), 47:77-83, 2007.

0100C002

T.Hatta, M.Yamada, E.Simamura, H.Shimada, M.Nimura, A.Matsumoto, J.Udagawa, R.Hashimoto, N.Higashi,
H.Otani: Mouse exo utero development system, J. Kanazawa. Med. Univ., 32:16-22, 2007 (in Japanese) .

－ 9 －

0110

Department of Molecular and Cell Structural Science (Anatomy Ⅱ)

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy,embryology,lymphatic vessels,microscopy.

Associate Professor

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve.

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy,central nervous system,immunocytochemistry.

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry,pituitary,cell proliferation,electron microscopy.

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian－ 10 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Associate Professor

SUGAI Tokio

Neurophysiology

Assistant Professor

YAMAMOTO Ryo

Neuroscience

Research Associate

ADACHI Hiroshi

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001(M.Murata), N.Kato: Autocorrelogram sorting: A novel method for evaluating negative-feedback regulation of spike
firing., Brain Res., 1133:27-33, 2007.

0120B002

R.Yamamoto, Y.Ueta, N.Kato: Dopamine induces a slow afterdepolarization in lateral amygdale neurons., J.
Neurophysiol., 98:984-992, 2007.

0120B003

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Signal propagation between the piriform cortex and the endopiriform
nucleus in the rat horizontal slice preparation., The Japanese journal of taste and smell research., 14:521-522,
2007 (in Japanese) .

Reviews
0120C001

N.Kato: Neurobiological basis of electroconvulsive therapy(ECT): consistency with the GABAergic deterioration
hypothesis for pahtogenesis of major depression, J. Kanazawa. Med. Univ., 32:73-81, 2007 (in Japanese) .
－ 11 －

0120C002

N.Kato: Neurobiological basis of electroconvulsive therapy(ECT): effects on synaptic plasticity, J. Kanazawa. Med.
Univ., 32:82-88, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0120I001

R.Yamamoto, Y.Ueta, N.Kato: A dopamine-induced slow after-depolarization in lateral amygdala neurons,
Neuroscience 2007, the 37th annual meeting of the Society for Neuroscience, (SanDiego, '07.11).

0120I002

K.Yamamoto, N.Kato: Intracellular beta amyloid enhances spike-induced calcium increase in neocortex pyramidal
neurons, Neuroscience 2007, the 37th annual meeting of the Society for Neuroscience, (SanDiego, '07.12).

－ 12 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO Toshishige

Circulatory Physiology

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

MIYAMAE Shunichi

Cardiac Electrophysiology

Assistant Professor

TAKANO Hiromichi

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

S.Cui, T.Shibamoto, Z.Zhao, H.Takano, Y.Kurata: l-NAME augments PAF-induced venoconstriction in isolated
perfused livers of rat and guinea pig, but not mouse, Prostaglandins Leukot. Essent. Fatty Acids., 76:277-283,
2007.

0130B002

S.Cui, T.Shibamoto, Z.Zhao, W.Zhang, H.Takano, Y.Kurata: Effects of L-NAME on thromboxane A2-induced
venoconstriction in isolated perfused livers from rat, guinea pig and mouse, Vascul. Pharmacol., 47:215-221, 2007.

0130B003

S.Cui, T.Shibamoto, H.Takano, W.Zhang, Y.Kurata: Leukotrienes and cyclooxygenase products mediate
anaphylactic venoconstriction in ovalbumin sensitized rat livers, Eur. J. Pharmacol., 576:99-106, 2007.

0130B004

Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto: Effects of pacemaker currents on creation and modulation ofhuman ventricular pacemaker: theoretical study with application to biological pacemaker engineering, Am. J.
Physiol. Heart Circ. Physiol., 292:H701-718, 2007.

0130B005

W.Liu, H.Takano, T.Shibamoto, S.Cui, Z-S.Zhao, W.Zhang, Y.Kurata: Involvement of splanchnic vascular bed inanaphylactic hypotension in anesthetized BALB/c mice, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293:R19471953, 2007.

－ 13 －

0130B006(K.Ogura), J.Miake, N.Sasaki, C.Iwai, U.Bahrudin, P.Li, M.Kato, K.Iitsuka, Y.Hirota, T.Koshida, Y.Yamamoto,
Y.Inoue, A.Yano, M.Adachi, O.Igawa, Y.Kurata, T.Morisaki, G.Shiota, Y.Shirayoshi, H.Ninomiya, I.Hisatome:
Inhibition of β-adrenergic signaling by intracellular AMP is independent of cell-surface adenosine receptors in rat
cardiac cells, J. Mol. Cell. Cardiol., 43:648-652, 2007.

0130B007T.Shibamoto, T.Shimo, S.Cui, W.Zhang, H.Takano, Y.Kurata, H.Tsuchida: The roles of mast cells and Kupffer
cells in rat systemic anaphylaxis, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293:R2202-R2209, 2007.

0130B008

T.Shibamoto, Z.Ruan, S.Cui, W.Liu, Z-S.Zhao, H.Takano, Y.Kurata, T.Koizumi, K.Kubo: The sinusoidal pressureduring ischemia-reperfusion injury in perfused mouse liver pretreated with or without L-NAME, J. Surg. Res.,
139:30-35, 2007.

0130B009

H.Takano, W.Lui, Z.Zhao, S.Cui, W.Zhang, T.Shibamoto: NG-nitro-L-arginine methyl ester, but not methylene
blue, attenuates anaphylactic hypotension in anesthetized mice, J. Pharmacol. Sci., 104::212-217, 2007.

0130B010(K.Watanabe), T.Koizumi, Z.Ruan, K.Kubo, A.Sakai, T.Shibamoto: Reduced pulmonary vascular reactivity after
cold exposure to acute hypoxia: A role of nitric oxide (NO), High Alt. Med. Biol., 8:43-49, 2007.

0130B011

Z.Zhao, T.Shibamoto, S.Cui, H.Takano, W.Zhang, Y.Kurata: Head-down tilt posture attenuates anaphylactic
hypotension in mice and rats, J. Physiol. Sci., 57:269-274, 2007.

0130B012

N.Karasawa, T.Shibamoto, S.Cui, H.Takano, Y.Kurata, H.Tsuchida: Hepatic pre-sinusoidal vessels contract inanaphylactic hypotension in rabbits, Acta Physiol. Scand., 189：15-22, 2007.

Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, W.Liu, S.Cui, H.Takano, Z-S.Zhan, Y.Kurata: Role of liver and splanchnic circulation in anaphylactic
hypotension in BALB/C mice, The 7th World Congress on Trauma, Shock, Inflammation and Sepsis, (Munich(Germany), '07.03)，Inflammation Res, 56(Suppl 2):S302-S303, 2007.

－ 14 －

0140

Department of Biochemistry Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

DATE Takayasu

Mechanisms of chromosome segregation and DNA repair.

Associate Professor

IWABUCHI Kuniyoshi

Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

MATSUI Tadashi

Functional analysis of protein kinases

Assistant Professor

HASHIMOTO Mitsumasa

The function analysis of protein kinase PKU-beta

Keywords of Research
gene analysis, double-stranded RNA-activated protein kinase (PKR), p53, 53BP1, 53BP2, RNA and DNA binding, PKUβ(TLK1), DNA repair, cell cycle, signal transduction

Outline of Research
PKU-beta/TLK-1 is a nuclear serine/threonine protein kinase, initially found in our laboratory. Recent study shows that it
controls multiple aspects of cell cycle, especially in progressions of S phase and mitosis. PKU-beta/TLK deficient cells or
it’s over-expressing cells contain aberrant chromosomes resulting in lethal. Main study in progress is to know how thekinase interacts with other cell cycle-dependent complex and regulates them.

Publications
Originals
0140B001(M.Matsumoto), K.Yaginuma, A.Igarashi, M.Imura, M.Hasegawa, K.Iwabuchi, T.Date, T.Mori, K.Ishizaki,
K.Yamashita, M.Inobe, T.Matsunaga: Perturbed gap-filling synthesis in nucleotide excision repair causes histone
H2AX phosphorylation in human quiescent cells, J. Cell. Sci., 6:1104-1112, 2007.

Others
0140F001

K.Iwabuchi: 53BP1 in repair of X-ray-induced DNA damage., Proceedings of the NIRS International Symposium on
Visualization of the Rediation Response at the Molecular and Cellular Levels., 67-77, 2007.

Presentations at Conference
International Conference (Synposium)
0140H001

K Iwabuchi: 53BP1 in repair of X-ray-induced DNA damage., National Institute of Radiological Sciences,
International Symposium, (Chiba, '07.03).

0140H002

M.Hashimoto, T.Matsui, K.Iwabuchi, T.Date: PKU-β/TLK1 regulates myosinⅡactivities, and is required forcentrosome separation and chromosome segregation., The 8th Internatinal Symposium on Chromosomal
Aberrations, (Awajishima, '07.10)，Proceedings, 49.

－ 15 －

International Conference (Presentations)
0140I001(F.Morohoshi), M.Tomita, K.Yamagata, M.Hashimoto, K.Ootsuka, I.Hayata, K.Iwabuchi, H.Tauchi, K.Sakai: BRCT
domain protein PTIP disruptants of chicken DT40 cells are viable, but defective in proliferation and highly sensitive
to ionizing radiation., The 13th International Congress of Radiation Research, (San Francisco, '07.07).

0140I002(H.Utumi), K.Iwabuchi, K.Takahashi, A.Tachibana: Low dose-rate effects of non-homologous end-joining repair
pathway of double strand breaks., The 13th International Congress of Radiation Research, (San Francisco, '07.07).

－ 16 －

0150

Department of Biochemistry Ⅱ

Name

Field of Specialization

Faculty
Title
Professor

Molecular mechanisms of angiogenesis, Alternative ｍRNA
processing, MicroRNA function
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein
YONEKURA Hideto

Associate Professor
Associate
Professor(Additional Post)

NAGAO Yosinobu

Spermatogenesis and epigenetics

Assistant Professor

TSURUOKA Naoki

Alternative processing of mRNA, Bioactivity of collagen tripeptide

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

J.Sato, N.Segami, M.Nishimura, Y.Yoshitake, K.Kaneyama, Y.Kitagawa: Expression of interleukin 8 in synovial
tissues in patients with internal derangement of the temporomandibular joint and its relationship with clinicalvariables, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 103:467-474, 2007.

0150B002(A.Takeuchi), Y.Yamamoto, K.Tsuneyama, C.Cheng, H.Yonekura, T.Watanabe, K.Shimizu, K.Tomita,
H.Yamamoto, H.Tsuchiya: Endogenous secretory receptor for advanced glycation endproducts as a novel
prognostic marker in chondrosarcoma, Cancer., 109:2532-2540, 2007.

0150B003(Y.Yamamoto), H.Yonekura, T.Watanabe, S.Sakurai, H.Li, A.Harashima, KM.Myint, M.Osawa, A.Takeuchi,
M.Takeuchi, H.Yamamoto: Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells,
Diabetes Res. Clin. Pract., 77 (Suppl 1):S30-40, 2007.

0150B004

J.Sato, N.Segami, Y.Yoshitake, K.Kaneyama, H.Yoshimura, K.Fujimura, Y.Kitagawa: Specific expression ofsubstance P in synovial tissues of patients with symptomatic,non-reducing internal derangement of thetemporomandibular joint: comparison with clinical findings, Br J Oral Maxillofac Surg, 45:372-377, 2007.

0150B005(M.Osawa), Y.Yamamoto, S.Munesue, N.Murakami, S.Sakurai, T.Watanabe, H.Yonekura, Y.Uchigata, Y.Iwamoto,H.Yamamoto: De-N-glycosylation or G82S mutation of RAGE sensitizes its interaction with advanced glycation
endproducts, Biochim. Biophys. Acta, 1770:1468-1474, 2007.

－ 17 －

0150B006

N.Tsuruoka, R.Yamato, Y.Sakai, Y.Yoshitake, H.Yonekura: Promotion by collagen tripeptide of Type I collagengene expression in human osteoblastic cells and fracture healing of rat femur, Biosci. Biotechnol. Biochem.,
71:2680-2687, 2007.

0150B007(I.Nozaki), T.Watanabe, M.Kawaguchi, H.Akatsu, K.Tsuneyama, Y.Yamamoto, K.Ohe, H.Yonekura, M.Yamada,
H.Yamamoto: Reduced expression of endogenous secretory receptor for advanced glycation endproducts inhippocampal neurons of Alzheimer's disease brains, Arch. Histol. Cytol., 70:279-290, 2007.

Reviews
0150C001

H.Yonekura, N.Tsuruoka, Y.Yoshitake: Autocrine regulation of angiogenesis, J. Kanazawa. Med. Univ., 32:8-15,
2007 (in Japanese) .

Others
0150F001(Y.Yamamoto), J.Miura, S.Sakurai, T.Watanabe, H.Yonekura, H.Tamei, H.Matsuki, K.Obata, Y.Uchigata, Y.
Iwamoto, H.Koyama, H.Yamamoto: Assaying soluble forms of receptor for advanced glycation end products.
(Response), Arterioscler. Thromb. Vasc. Biol., 27:e33-34, 2007.

－ 18 －

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor(Additional Post)

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Researcher

NISHIZAWA Naoki

Researcher

NOMURA Mihoko

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystemPharmacology in cardiovascular system, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular system, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular system, Cancer chemotherapy

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, photolysis, excitable membrane, cardiovascular system,
ischemic disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary
circulation, nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor
drug, proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

J.Yoshida, T.Ishibashi, M.Nishio: G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, inhuman epidermoid carcinoma A431 cells, Biochem. Pharmacol., 73：943-953, 2007.

Presentations at Conference
International Conference (Presentations)
0160I001

T. Ishibashi, N. Nishizawa, M. Nomura, J. Yoshida, M. Nishio: Arterio-venous difference of nitrite kinetics inanesthetized rabbits, Second International Role of Nitrite in Physiology, Pathophysiology, and Therapeutics
Meeting, (Bethesda Meryland, USA, '07.09).

－ 19 －

0170

Department of Oncologic Pathology

Faculty
Title

Name

Field of Specialization

Professor

TANAKA Takuji

Inhibition of carcinogenesis, Oncologic pathology of digestive organ,
Experimental pathology

Professor

SUGIE Shigeyuki

Experimental pathology, Oncologic pathology of digestive organ

Professor(Additional Post)

KOHNO Hiroyuki

Experimental pathology,Tumor immunology

Assistant Professor

YASUI Yumiko

Lipids in carcinogenesis

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Books
0170A001

T.Tanaka, S.Miyamoto, Y.Yasui, R.Suzuki: Cancer chemoprevention in preclinical animal studies., Research
Advances in Cancer 7 (Mohan, R.M.), 17-47, Global Research Network, Kerala (India), 2007.

0170A002

T.Tanaka: Inflammation and cancer, Cancer: Disease Progression and Chemoprevention(Takuji Tanaka), 27-44,
Research Signpost, Kerala (India), 2007.

0170A003(S.Miyamoto), Y.Yausi, A.Murakami, T.Tanaka: Molecular mechanism of colorectal carcinogenesis, Cancer:
Disease Progression and Chemoprevention(Takuji Tanaka), 45-56, Research Signpost, Kerala (India), 2007.

0170A004

T.Tanaka, S.Miyamoto, Y.Yausi, H.Kohno, S.Sugie: Obesity: a risk for hepatocelullar carcinoma, Cancer: Disease
Progression and Chemoprevention(Takuji Tanaka), 57-74, Research Signpost, Kerala (India), 2007.

0170A005(E.O.Farombi), T.Tanaka: Cancer chemoprevention with Zingiberaceae and citrus-derived phytochemicals:
Biochemical and molecular mechanisms, Cancer: Disease Progression and Chemoprevention(Takuji Tanaka), 167184, Research Signpost, Kerala (India), 2007.

0170A006(M.Hosokawa), Y.Yausi, S.Suzuki, H.Kohno, T.Tanaka: Chemopreventive effects of conjugated linolenic acids oncolon cancer, Cancer: Disease Progression and Chemoprevention(Takuji Tanaka), 239-254, Research Signpost,
Kerala (India), 2007.

－ 20 －

Publications
Originals
0170B001(H.Makita), M.Mutoh, T.Maruyama, K.Yonemoto, A.Kobayashi, H.Fujitsuka, M.Toida, T.Shibata, S.Miyamoto,Y.Yasui, R.Suzuki, K.Wakabayashi, T.Tanaka: A prostaglandin E2 receptor subtype EP1-selective antagonist,
ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis, Carcinogenesis, 28:677-684,
2007.

0170B002(M.Tang), K.Ogawa, M.Asamoto, N.Hokaiwado, A.Seeni, S.Suzuki, S.Takahashi, T.Tanaka, K.Ichikawa, T.Shirai:
Protective effects of citrus nobiletin and auraptene in transgenic rats developing adenocarcinoma of the prostate(TRAP) and human prostate carcinoma cells, Cancer Sci., 98:471–477, 2007.

0170B003

R.Suzuki, S.Miyamoto, Y.Yasui, S.Sugie, T.Tanaka: Global gene expression analysis of the mouse colonic mucosa
treated with azoxymethane and dextran sodium sulfate, BMC Cancer, 7:84, 2007.

0170B004

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, F.Beppu, M.Hosokawa, K.Miyashita, T.Tanaka: 9trans,11transconjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats,
Nutr. Cancer., 59:82-91, 2007.

0170B005

Y.Yasui, R.Suzuki, S.Miyamoto, T.Tsukamoto, S.Sugie, H.Kohno, T.Tanaka: A lipophilic statin, pitavastatin,
suppresses inflammation-associated mouse colon carcinogenesis, Int. J. Cancer, 121:2331-2339, 2007.

0170B006(M.Nakanishi), H.Tazawa, N.Tsuchiya, T.Sugimura, T.Tanaka, H.Nakagama: Mouse strain differences in
inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to
PhIP-induced large bowel carcinogenesis, Cancer Sci., 98:1157–1163, 2007.

0170B007(N.Ando), M.Shimizu, M.Okuno, R.Matsushima-Nishiwaki, H.Tsurumi, T.Tanaka, H.Moriwaki: Expression ofretinoid X receptor α is decreased in 3’-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in
rats, Oncol. Rep., 18:879-884, 2007.

0170B008(K.Sakano), M.Takahashi, M.Mutoh, N.Niho, M.Komiya, H.Sato, T.Tanaka, T.Sugimura, K.Wakabayashi: Enhanced
thyroid carcinogenicity of N-nitrobis(2-oxo-propyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model oftype 2 diabetes mellitus, Carcinogenesis, 28:2193-2198, 2007.

0170B009

K.Hayashi, R.Suzuki, S.Miyamoto, S.Yoshitani, H.Kohno, S.Sugie, S.Takashima, T.Tanaka: Citrus auraptene
suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice, Nutr. Cancer., 58:7584, 2007.

0170B010(K.Takeda), H.Utsunomiya, S.Kakiuchi, Y.Okuno, K.Oda, K.Inada, Y.Tsutsumi, T.Tanaka, K.Kakudo: Citrus
auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils, J. Oleo Sci.,
56:253-260, 2007.

0170B011

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, K.Wakabayashi, T.Tanaka: Ursodeoxycholic acid versus sulfasalazine incolitis-related colon carcinogenesis in mice, Clin. Cancer Res., 13:2519-2525, 2007.

0170B012

H.Kohno, M.Takahashi, Y.Yasui, R. Suzuki, S.Miyamoto, Y.Kamanaka, M.Naka, T.Maruyama, K.Wakabayashi,
T.Tanaka: A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large
bowel carcinogenesis in male ApcMin/+ mice, Int. J. Cancer, 121:506-513, 2007.

0170B013

H.Kohno, Y.Totsuka, Y.Yasui, R.Suzuki, S.Sugie, K.Wakabayashi, T.Tanaka: Tumor-initiating potency of a novel
heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, Int. J. Cancer, 121:1659-1664,
2007.

0170B014

K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki: Dietary
β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male
ICR mice, Oncol. Rep., 17:297-304, 2007.

0170B015(S.Miyamoto), R.Suzuki, Y.Yasui, H. Kohno, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka: Lack of enhancing effectof lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran
sodium sulfate, J. Toxicol. Pathol., 20:93-100, 2007.

－ 21 －

Reviews
0170C001

T.Tanaka, S.Sugie: Inhibition of colon carcinogenesis by dietary non-nutritive compounds, J. Toxicol. Pathol.,
20:215-235, 2007.

0170C002(B.Narayan), M.Hosokawa, Y.Yasui, R.Suzuki, H.Kohno, T.Tanaka, K.Miyashita: Chemopreventive effects ofconjugated linolenic acids (CLN) occurring in plant seed oils, Current nutrition & food science., 3:309-318, 2007.

Presentations at Conference
International Conference (Synposium)
0170H001

T.Tanaka: Citrus compounds inhibit inflammation- and obesity-related carcinogenesis in mice, Cancer
Chemoprevention Symposium (12th World Congress on Advances in Oncology and 10th International Symposium on
Molecular Medicine), (Crete (Greece), '07.10).

0170H002

T.Tanaka: Preclinical chemoprevention study on inflammation- and obesity-related colon carcinogenesis, 9thInternational Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis (ICMAA-2007), (Jeju Island(Korea), '07.12).

International Conference (Presentations)
0170I001

K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki: Dietarybeta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis inmale ICR mice, The 22nd Annual EAU Congress, (Berlin, '07.03).

0170I002

Y.Yasui, H.Kohno, R.Suzuki, S.Sugie, N.Niho, M.Takahashi, K.Wakabayashi, T.Tanaka: Dextran sodium sulfate
strongly promotes colon carcinogenesis in ApcMin/+ mice, The 2nd Biennial Svientific Meeting of International Society for
Gastrointestinal Hereditary Tumours, (Yokohama, '07.03).

0170I003

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, T.Tanaka: A lipophilic statin, pitavastatin inhibits inflammationassociated mouse colon carcinogeness., 98th Annual Meeting of American Association for Cancer Research, (LosAngeles, '07.04).

0170I004(M.Shimizu), Y.Shirakami, H.Sakai, K.Hata, Y.Hirose, T.Tanaka, H.Moriwaki: EGCG suppresses azoxymethaneinduced colonic premalignant lesions in male C57BL/KsJ-db/db mice, 98th Annual Meeting of American
Association for Cancer Research, (Los Angeles, '07.04).

0170I005(Y.Shirakami), M.Shimizu, T.Tanaka, H.Moriwaki: Chemopreventive effects of EGCG and Polyphenon Eon
inflammation-related mouse colon carcinogenesis induced by AOM and DSS, 98th Annual Meeting of American
Association for Cancer Research, (Los Angeles, '07.04).

0170I006(S.Miyamoto), K.Hayashi, R.Suzuki, H.Kohno, S.Sugie, S.Takashima, A.Murakami, H.Ohigashi, T.Tanaka: Citrus
auraptene suppreses azoxymethane-induced colonic preneoplasia in db/db mice, 98th Annual Meeting of American
Association for Cancer Research, (Los Angeles, '07.04).

0170I007

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, T.Tanaka: Ursodeoxycholic acid inhibits colitis-related colon
carcinogenesis in mice: A comparative study regarding the effect of sulphasalazine, 98th Annual Meeting ofAmerican Association for Cancer Research, (Los Angeles, '07.04).

0170I008

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, S.Sugie, T.Tanaka: A lipophilic statin, pitavastatin inhibits colitisrelated colon carcinogenesis in mice, The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research, (Gifu,'07.08).

0170I009

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, S.Sugie, T.Tanaka: Ursodeoxycholic acid inhibits colitis-related colon
carcinogenesis in mice, The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research, (Gifu, '07.08).

0170I010

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).
－ 22 －

0170I011

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

0170I012(K.Tatematsu), Y.Mori, S.Sugie, T.Tanaka, H.Mori: Tissue-specific modification by curcumin of mutagenic
activation of carcinogenic N-nitroso compounds by CYP2B1 and 2E1 in rats, 3rd International Conference on
Polyphenols and Health (ICPH2007), (Kyoto, '07.11).

0170I013(M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Kamataki, T.Nohmi: Chemopreventive
effects of nobiletin, a citrus constituent, against the genotoxicity of NNK, a tobacco-specific nitrosamine, in thelung of gpt delta transgenic mice, 9th International Conference on Mechanisms of Antimutagenesis andAnticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

0170I014

Y.Yasui, M.Kim, S.Miyamoto, R.Ishigamori-Suzuki, S.Sugie, T.Tanaka: The inhibitory effect of pitavastatin oncolitis-related colon carcinogenesis in mice, 9th International Conference on Mechanisms of Antimutagenesis andAnticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

0170I015

T.Tanaka, Y.Yasui, M.Kim, S.Miyamoto, F.Epifano, M.Curini, S.Genovese, R.Ishigamori-Suzuki: A novel prodrugof ferulic acid suppresses AOM/DSS-induced mouse colon carcinogenesis, 9th International Conference on
Mechanisms of Antimutagenesis and Anticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

0170I016

M.Kim, Y.Yasui, S.Miyamoto, S.Sugie, A.Murakami, R.Ishigamori-Suzuki, T.Tanaka: Dietary pitavastatin inhibits
4-nitroquinoline-1-oxide-induced carcinogenesis in the upper-digestive organs of rasH2 mice, 9th International
Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis (ICMAA-2007), (Jeju Island (Korea),'07.12).

－ 23 －

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

Professor

KATSUDA Shogo

Vascular pathology, Pathophysiology of ECM

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Senior Assistant Professor

SATO Katsuaki

Neuropathology

Researcher

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

N.Ainoda, H.Onishi, Y.Ueda, A.Hori, K.Miura, K.Miyazawa, K.Suzuki: Increase in knowledge of ignorance during
problem-based learning sessions:possible improvement of metacognition, Medical education (Japan)., 38:11-17,
2007.

0180B002

I.Shima, S.Katsuda, Y.Ueda, N.Takahashi, H.Sasaki: Expression of matrix metalloproteinases in wound healing after
glaucoma filtration surｇery in rabbits, Ophthalmic Res., 39:315-324, 2007.

0180B003

Z.Wang, J.Xu, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma: Chronic pulmonary artery occlusion increases
alveolar fluid clearance in rats, J. Thorac. Cardiovasc. Surg., 134:1213-1219, 2007.

Reviews
0180C001

Y.Ueda, Y.Kanazawa, M.Shimazaki, K.Sato, G.Ming, D.Jiang, H.Tsuchiya, K.Tomita, S.Katsuda: Plakoglobin, anovel tumor supressing protein, to control metastasis of soft tissue sarcomas, J. Kanazawa. Med. Univ., 32:1-7,
2007 (in Japanese) .

－ 24 －

Case Reports
0180D001

K.Sato, Y.Ueda, J.Sugaya, M.Ozaki, M.Hisaoka, S.Katsuda: Extrauterine endometrial stromal sarcoma withJAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor, Virchows Arch.,
450:349-353, 2007.

0180D002(S.Kasashima), H.Minato, M.Kobayashi, Y.Ueda, Y.Oda, S.Hashimoto, M.Inoue: Alveolar soft part sarcoma of theendometrium with expression of CD10 and hormone receptors, APMIS., 115:861-865, 2007.

0180D003

K.Sato, Y.Oda, Y.Ueda, S.Katsuda: Fasciitis ossificans of the breast, Pathol. Res. Pract., 203:737-739, 2007.

0180D004

M.Sagawa, Y.Ueda, F.Matsubara, H.Sakuma, Y.Yoshimitsu, H.Aikawa, K.Usuda, H.Minato, T.Sakuma:
Intrapulmonary solitary fibrous tumor diagnosed by immunohistochemical and genetic approaches: report of a case,
Surg Today, 37:423-425, 2007.

0180D005

K.Sato, T.Terauchi, M.Nakano, M.Takenaka, Y.Asakura, N.Kurose, T.Nojima, Y.Ueda: A case of urothelial
carcinoma of the urinary bladder presenting intracytoplasmic lumina, J. Jpn. Soc. Clin. Cytol., 46:48-52, 2007 (inJapanese) .

0180D006

K.Sato, M.Takenaka, T.Terauchi, M.Nakano, Y.Asakura, T.Nojima, Y.Ueda, S.Katsuda: A case of thyroid
adenomatous nodule with bizarre nuclei, J. Jpn. Soc. Clin. Cytol., 46:149-152, 2007 (in Japanese) .

0180D007

H.Shikata, Y.Ueda, H.Nishizawa, K.Hida, J.Matsubara: A case of invasive group a streptococcal infection
resembling phlegmasia cerulea dolens-a case of toxic shock-like syndrome-, The Journal of the Japanese Practical
Surgeon Society., 68:1088-1092, 2007 (in Japanese) .

0180D009

T.Terauchi, M.Takenaka, Y.Asakura, M.Nakano, K.Sato, M.Sagawa, N.Kurose, T.Nojima: Pulmonary pleomorphic
carcinoma: two-case report, J. Jpn. Soc. Clin. Cytol., 46：227-231, 2007 (in Japanese) .

Short Communications
0180E001

K.Sato, Y.Ueda, S.Katsuda, K.Tsuchihara: Myelolipoma of the lung: a case report and brief review, J. Clin.
Pathol., 60:728-730, 2007.

Others0180F001

K.Sato, H.Tachibana, S.Morinaga, Y.Ueda, S.Katsuda: Sertoli cell tumor of the testis, not otherwise specified,presenting extensive hemorrhage and overexpression of α-methylacyl-CoA racemase (AMACR/P504S), VirchowsArch., 450:361-363, 2007.

0180F002

K.Sato, Y.Shimode, A.Itoi, Y.Ueda, S.Katsuda: Salivary duct carcinoma of the parotid gland presenting KIT(CD117) overexpression, Histopathology, 51:114-115, 2007.

Presentations at Conference
International Conference (Presentations)
0180I001

T.Miyanaga, S.Kawakami, S.Katsuda, Y.Ueda, M.Shimasaki: Degradation and Absorption Processes of Hyaluronic
Acid Filler Injected in, 17th Japan-China Joint Meeting on Plastic Surgery, (Tokyo, '07.10).

－ 25 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology，Neuroimmunology

Associate Professor

SAITO Mineki

Neurology，Neurovirology

Assistant Professor

TANIURA Naoko

Neurovirology

Assistant Professor

SAITOU Kousuke

Virology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001(F.Umehara), H.Nose, M.Saito, M.Fukuda, M.Ogino, T.Toyota, T.Yuhi, K.Arimura, M.Osame: Abnormalities ofspinal magnetic resonance images implicate clinical variability in human T-cell lymphotropic virus type I-assoiatedmyelopathy, J. Neurovirol., 13:260-267, 2007.

0190B002

K.Asakura, H.Murayama, T.Himeda, Y.Ohara: Expression of L* protein of Theiler’s murine encephalomyelitis
virus in the chronic phase of infection, J. Gen. Virol., 88:2268-2274, 2007.

0190B003(H.Nose), R.Kubota, NP.Seth, PK. Goon, Y.Tanaka, S.Izumo, K.Usuku, Y.Ohara, KW.Wucherpfennig,
CRM.Bangham, M.Osame, M.Saito: Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells byuse of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele
and its immunodominant peptide, J. Infect. Dis., 196:1761-1772, 2007.

Presentations at Conference
International Conference (Presentations)
0190I001

M.Saito, AH.Sabouri, S,Izumo, M.Osame, Y.Ohara: Imoaired maturation and function of HTLV-1 specific CTLs in
HAM/TSP., 8th International Symposium on NeuroVirology, (San Diego, '07.10).

－ 26 －

0200

Department of Fundamental Research for CAM

Faculty
Title

Name

Field of Specialization

Professor

YAMAGUCHI Nobuo

Developmental immunology, Defense immunity, Tumor immunity,
Complementary & alternative medicine

Associate Professor

SHIMIZU Shoji

Immunology, Protective immunology, Tumor immunology

Senior Assistant Professor

MATSUNO Hideo

Allergy, Otolaryngology

Assistant Professor

MATSUBA Shintaro

Complementary & alternative medicine, Immunological pharmacology

Keywords of Researchpregnancy, maternal immunization, offspring, immune suppression, acquired immunodeficiency, immunomodulator, oral
immunity, herbal medicine, cytokine

Outline of Research
Our research is founded on immunology. To date, we have studied fields such as fetomaternal immunity, tumor immunity
and infectious immunity. With the graduate school reorganization in 2003, the name of the chair was changed with"Complementary and alternative medicine". Since then, we started the trial which verified alternative medicine of all thecountries of world by the immunological parameters. In order to achive these ends as effectively as possible, we planned the
publication of new international journal, Evidence-based Complementary and Alternative Medicine (eCAM). The journal
eCAM was published in 2004 and reached vol. 4th at present. In recent years, it has been proven that the neuroendocrinosystem adjusts the function of immune system and that there is a bidirectional regulation mechanism in these systems. We
examine the effect of hot spring hydrotherapy and walking exercise on number and function of the immunocompetent cells.
Hereafter, we aim at the establishment of an assessment of the alternative medicine throughout immunological parameters.

Publications
Originals
0200B001

N.Yamaguchi, T.Takahashi, M.Sakuma, T.Sugita, K.Uchikawa, S.Sakaihara, T.Kanda, M.Arai, K.Kawakita:
Acupuncture regulates leukocyte subpopulations in human peripheral blood, Evid Based Complement Alternat
Med, 4:447-453, 2007.

Others
0200F001

T.Takahashi, T.Kanda, N.Yamaguchi: Influenza Vaccines, N. Engl. J. Med., 356:1172-1173, 2007.

－ 27 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Associate Professor

IKEDA Teruaki

Immunological and biochemical studies of parasitic diseases

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease，tick-borne disease

Senior Assistant Professor

ICHIKAWA Hidetaka Immunological study for parasitic diseases

Faculty

Keywords of Researchparasite, paragonimiasis, fascioliasis, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating
antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba,
metacercaria, excystment, atopic dermatitis, mite, Myobia musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Study on the invading mechanism of lung flukes into their final hosts.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Development of immunological and molecular biological diagnosis of parasitic diseases.

Publications
Originals
0210B001(H.Fujita), N.Takada, H.Kawabata, F.Ishiguro, S.Yamamoto, Y.Oikawa, Y.Yano, Xiao-Hang Ma, Hong-Shik Oh:
Some suggestive records of rickettsiae isolated from ticks in Korea and central China, Ann. rep. Ohara Hosp.,
47:21-24, 2007.

－ 28 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

FUKUNAGA Toshiharu

Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Assistant Professor

KINOSHITA Erikosurgical pathology, molecular pathology

surgical pathology, molecular pathology, basic science on boneand soft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura
laboratory medicine, standardization of blood gas analysis,
pulmonary function test

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001

A.Nakagawa, K.Ueno, M.Ito, S.Okamoto, K.Uehara, H.Ito, S.Mishina, E.Kinoshita, T.Nojima, H.Takahashi,
H.Ikawa, S.Takashima, M.Nishizawa, S.Nakano, T.Kigoshi, H.Nakabayashi, K.Uchida: Insulin responses toselective arterial calcium infusion under hyperinsulinemic euglycemic glucose clamps: case studies in adultnesidioblastosis and childhood insulinoma, Endocr. J., 54:27-33, 2007.

Reviews
0220C001(M.Hirokawa), T.Koshikawa, K.Higuchi, H.Minato, M.Tsuzuku, K.Mukai: Reporting system of salivary glandaspiration cytology, J. Jpn. Soc. Clin. Cytol., 46:160-163, 2007 (in Japanese) .

Case Reports
0220D001

H.Yokota, M.Matoba, H.Tonami, T.Hasegawa, H.Saito, N.Kurose: Imaging findings in primary adenosquamous
carcinoma of the liver : a case report, Clin. Imaging., 31:279-282, 2007.

－ 29 －

0220D002

K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki: Prostate cancer producing
carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, J.
Kanazawa. Med. Univ., 32：29-31, 2007.

0220D003

K.Sato, T.Terauchi, M.Nakano, M.Takenaka, Y.Asakura, N.Kurose, T.Nojima, Y.Ueda: A case of urothelial
carcinoma of the urinary bladder presenting intracytoplasmic lumina, J. Jpn. Soc. Clin. Cytol., 46:48-52, 2007 (inJapanese) .

0220D004

K.Sato, M.Takenaka, T.Terauchi, M.Nakano, Y.Asakura, T.Nojima, Y.Ueda, S.Katsuda: A case of thyroid
adenomatous nodule with bizarre nuclei, J. Jpn. Soc. Clin. Cytol., 46:149-152, 2007 (in Japanese) .

0220D005

T.Terauchi, M.Takenaka, Y.Asakura, M.Nakano, K.Sato, M.Sagawa, N.Kurose, T.Nojima: Pulmonary pleomorphic
carcinoma: two-case report, J. Jpn. Soc. Clin. Cytol., 46：227-231, 2007 (in Japanese) .

Others
0220F001

Hiroshi Minato: A case of nasal tumor in a newborn infant, Pathology and clinical medicine., 25:594-595, 2007 (inJapanese) .

0220F003(J.Shimizu), Y.Arano, T.Murata, T.Yachi, Y.Tsunamura, T.Nomura, H.Minato: Intrathoracic giant malignant
peripgerak nerve sheath tumor in neurofibromatosis type I (von Recklinghausen's disease): report of a case,
Medical journal of Mutual Aid Association., 56:203-208, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0220I001

H.Minato, S.Kaji, E.Kinoshita, N.Kurose, T.Nojima: Solitary intrapulmonary cystic lymphangioma, Pulmonary
Pathology Society 2007 Biennial Meeting, (Santa Fe, New Mexico, USA, '07.06).

－ 30 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stress

Associate
Professor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Senior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Senior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(W.Teeyakasem), M.Nishijo, R.Honda, S.Satarug, W.Swaddiwudhipong, W.Ruangyuttikarn: Monitoring of cadmium
toxicity in a Thai population with high-level environmental exposure, Toxicol. Lett., 169:185-195, 2007.

0230B002

S.Yoneyama, K.Miura, S.Sasaki, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Dietaryintake of fatty acids and serum C-reactive protein in Japanese, J Epidemiol, 17:86-92, 2007.

0230B003(Y.Suwazono), E.Kobayashi, M.Dochi, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa:
Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in
the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia, Clin. Exp.
Med., 7:108-114, 2007.

0230B004

Y.Morikawa, H.Nakagawa, K.Miura, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa: Effect ofshift work on body mass index and metabolic parameters, Scand. J. Work Environ. Health, 33:45-50, 2007.

0230B005(K.Fujikake), M.Miyao, R.Honda, M.Omori, Y.Matsuura, H.Takada: Evaluation of high qualiry LCDs displaying
moving pictures, on the basis of the form obtained from statokinesigrams, Forma, 22:199-206, 2007.

0230B006

Q.Jingtao, H.Sasaki, L.Zhongxin, Z.Jinsheng, W.Kaili, M.Kojima, Y.Sakamoto, R.Honda, Y.Kawakami,
Y.Yamashiro, Z.Jinsong, K.Sasaki, Japan-China Co-operative Study Group: Ｃｕｒｒｅｎｔ ｓｔａｔｕｓ ａｂｏｕｔ ｂｌｉｎｄｎｅｓｓ
ａｍｏｎｇ ｌｏｗ‐income farmers in Sanya district, hainan, China, Japanese journal of clinical ophthalmology Rinsho
ganka., 61:411-416, 2007 (in Japanese) .

－ 31 －

Others
0230F001

Y.Noborisaka, R.Honda, M.Ishizaki, M.Nakata, Y.Yamada: Alcohol and cigarette consumption, renal function andblood pressure in middle-aged healthy men, J Hum Hypertens, 21:966-968, 2007.

Presentations at Conference
International Conference (Presentations)
0230I001

M.Nakata, P.Lindberg: Work-related musculoskeletal disorders(WRMSDs) and an uninformed society－what todo?, Third International Conference on the History of Occupational and Environmental Health, (Birmingham,'07.04).

0230I002

K.Sasaki, H.Sasaki, R.Honda, Y.Kawakami, M.Kojima, Y.Sakamoto, J.Qu, Y.Yamashiro, J.Zhang, Z.Lilu: HighPrevalence of Pterygium in the Population of a Tropical Area in China -Sanya Eye Study-, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0230I003

K.Nagai, H.Sasaki, R.Honda, M.Kojima, Y.Sakamoto, J.Qu, K.Sasaki: Prevalence of cataract in eyes with posterior
vitreous detachment, Association for Research in Vision and Ophthalmology, (Florida, '07.05).

0230I004

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: The relationshipof axial length and three main types of cataract in the population of a tropical area of China, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0230I005

Pham-The T, Nambunmee K, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow-up study (from 1998
to 2006) about effects of cadmium on renal functions among Japanese population living in a non-polluted area., 6th
Annual Congress of Asia-Pacific Association of Medical Toxicology, (Bangkok, '07.12).

0230I006

K.Nagai, H.Sasaki, R.Honda, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: Change of light scattering intensity ineyes with posterior vitreous detachment, Monzen eye study, US-Japan Cooperative Cataract Research Group
Meeting, (Hawaii, '07.12).

－ 32 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

MIURA Katsuyuki

Cardiovascular epidemiology, preventive cardiology, clinicalepidemiology

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

NAKANISHI Yumiko

Preventive medicine

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001

N.Ainoda, H.Onishi, Y.Ueda, A.Hori, K.Miura, K.Miyazawa, K.Suzuki: Increase in knowledge of ignorance during
problem-based learning sessions:possible improvement of metacognition, Medical education (Japan)., 38:11-17,
2007.

0240B002(W.Teeyakasem), M.Nishijo, R.Honda, S.Satarug, W.Swaddiwudhipong, W.Ruangyuttikarn: Monitoring of cadmium
toxicity in a Thai population with high-level environmental exposure, Toxicol. Lett., 169:185-195, 2007.

0240B003

S.Yoneyama, K.Miura, S.Sasaki, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Dietaryintake of fatty acids and serum C-reactive protein in Japanese, J Epidemiol, 17:86-92, 2007.

0240B004(T.Tanaka), T.Okmura, Z.Yamagata, T.Takebayashi, U.Tamura, Y.Kusaka, S.Urano, Y.Miyoshi, A.Okayama,
H.Ueshima, HIPOP-OHP Research Group, H.Nakagawa, K.Miura: Awareness and ｔreatment of hypertension andhypercholesterolemia in Jpanese workers:the high-risk and population strategy for occupational healthpromotion(HIPOP-OHP)study, Hypertens. Res., 30:921-928, 2007.

－ 33 －

0240B005

A.Nasermoaddeli, K.Miura, A.Matsumori, Y.Soyama, Y.Morikawa, A.Kitabatake, Y.Inaba, H.Nakagawa: Prognosis
and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study,
Heart, 93:711-715, 2007.

0240B006(Y.Hayashino), S.Fukuhara, Y.Suzukamo, T.Okamura, T.Tanaka, H.Ueshima, HIPOP-OHP Research Group,
H.Nakagawa, K.Miura: Relation between sleep qality and quwantity,quality of life, and risk of developing diabetes inhealthy workers in Japan: the high-risk and population strategy for occupational health promotion(HIPOPOHP)study, BMC Public Health., 7:129, 2007.

0240B007(The Emerging Risk Factors Collaboration.), H.Nakagawa, K.Miura: The emerging risk factors collaboration:
analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104
prospective studies of cardiovascular diseases, Eur. J. Epidemiol., 22:839-869, 2007.

0240B008

M.Nishijo, J.Kuriwaki, E.Hori, K.Tawara, H.Nakagawa, H.Nishijo: Effects of materinal exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behiavioral development in offspring rats,
Toxicol. Lett., 173:41-47, 2007.

0240B009

M.Sakurai, T.Takamura, T.Ota, H.Ando, H.Akahori, K.Kaji, M.Sasaki, Y.Nakanuma, K.Miura, S.Kaneko: Liversteatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease, J. Gastroenterol.,
42:312-317, 2007.

0240B010(Y.Suwazono), E.Kobayashi, M.Dochi, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa:
Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in
the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia, Clin. Exp.
Med., 7:108-114, 2007.

0240B011

Y.Morikawa, H.Nakagawa, K.Miura, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa: Effect ofshift work on body mass index and metabolic parameters, Scand. J. Work Environ. Health, 33:45-50, 2007.

0240B012

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

0240B013

K.Kitaoka-Higashiguchi, M.Sasaki, Y.Morikawa, H.Nakagawa: Applying the General Coping Questionnaire tonurses and the prospcet of the shortened version, Hokuriku Japanese Journal of Public Health., 33:56-59, 2007 (inJapanese) .

Short Communications
0240E001(T.Kido), S.Maruzeni, H.Suzuki, Y.Odamae, M.Muranaka, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa,
TM.Hung, LTH.Thom, PT.Dung, DD.Nhu, H.Oka, K.Noguchi: Five years studies on the long term effects ofwaragent orange/dioxin on human health in Vietnam, Organohalogen Compounds., 69:572-575, 2007.

0240E002(M.Muranaka), T.Kido, Y.Odamae, H.Suzuki, R.Naganuma, H.Nakagawa, M.Nishijo, K.Tawara, TM.Hung,
LTH.Thom, PT.Dung, DD.Nhu: An epidemiological study on health effects by dioxin in Vietnam; comparison ofvisual acuity of junior high school students between herbicide sprayed and non-sprayed areas, Organohalogen
Compounds., 69:2035-2038, 2007.

0240E003

K.Tawara, M.Nishijo, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, TM.Hung, LTH.Thom, PT.Dung, DD.Nhu:
Association of having birth defect chiledren with serum dioxin levels in Vietnam, Organohalogen Compounds.,
69:568-571, 2007.

0240E004

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pam, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)disturbed development of taste preference in rat offspring,
Organohalogen Compounds., 69:1809-1812, 2007.

0240E005

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, Organohalogen Compounds., 69-2031-2034,
2007.

－ 34 －

Presentations at Conference
International Conference (Synposium)
0240H001

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, 27th International symposium on halogenatedpersistent organic pollutants, (Tokyo, '07.08).

0240H002(K.Nambunmee), T.Pham-The, R.Honda, M.Nishijo, K.Miura, H.Nakagawa, W.Rungyuttikarn: Association of renal
tubular injury and bone resoption induced by cadmium expusure of inhabitants living in polluted area, Maesot
district, Tak province, Thailand, 6th Annual congress of Asia Pacific association of medical toxicology, (Bangkok,'07.12).

0240H003(T.Pham-The), K.Nambunmee, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow up study about
effects of cadmium (Cd) on renal functions among Japanese population living in a non-polluted area, 6th Annual
congress of Asia Pacific association of medical toxicology, (Bangkok, '07.12).

International Conference (Presentations)
0240I001

K.Miura, A.Matsumori, Y.Morikawa, Y.Inaba, M.Nagai, H.Nakagawa: Predictive Score to Predict the Prognosis of
Cardiomyopathies: from a Nationwide Study in Japan, 1st International Congress of Cardiomyopathy and Heart
Failure, (Kyoto, '07.03).

0240I002

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pham, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbed development of taste preference in rat off-springs, 27th
International symposium on halogenated persistent organic pollutants, (Tokyo, '07.08).

0240I003

Pham-The T, Nambunmee K, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow-up study (from 1998
to 2006) about effects of cadmium on renal functions among Japanese population living in a non-polluted area., 6th
Annual Congress of Asia-Pacific Association of Medical Toxicology, (Bangkok, '07.12).

－ 35 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology，Drug Dependence

Research Associate

TAKEICHI Toshiaki

hemorheologe

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning－ 36 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

YASUDA Yukio

Associate Professor

AINODA Noriko

Associate Professor

HORI Ariyuki

Assistant Professor

KURODA Naohiro

Facultyundergraduate clinical teaching, graduate education of physicians,
medical education
medical education, educational assessment, problem-based learning,communication
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Originals
0260B001

N.Ainoda, H.Onishi, Y.Ueda, A.Hori, K.Miura, K.Miyazawa, K.Suzuki: Increase in knowledge of ignorance during
problem-based learning sessions:possible improvement of metacognition, Medical education (Japan)., 38:11-17,
2007.

Case Reports
0260D001

H.Kakinuma, A.Hori, M.Ito, T.Nakamura, H.Takahashi: An inherited disorder characterized by repeated episodesof bilateral ballism: a case report, Mov. Disord., 22:2110-2131, 2007.

－ 37 －

0300

Department of Cardiovascular Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

Professor(Additional Post)

MATSUI Shinobu

Heart failure

Associate Professor

TSUGAWA Hiroichi

Arrhythmia, Catheter ablation

Associate Professor

ASAJI Takayoshi

Heart failure

Associate Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Senior Assistant Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Senior Assistant Professor

UENISHI Hiroaki

Ischemic heart disease, Coronary intervention

Assistant Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Assistant Professor

SATAKE Osamichi

Cardiomyopathy

Assistant Professor

SATO Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

KASENO Kenichi

Arrhythmia, Catheter ablation

Assistant Professor

NOMURA Yusuke

nuclear cardiology

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease，Coronary intervention

Research Doctor

ISHIDA Masaski

Hypertension

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001(Y. Ozaki), T. Yamaguchi, T. Suzuki, M. Nakamura, M.Kitayama, H. Nishikawa, T. Inoue, K. Hara, F. Usuba, M.
Sakurada, K. Awano, H. Matsuo, S. Ishiwata, T. Yasukawa, T. F. Ismail, H.Hishida, O. Kato: Impact of cutting
balloon angioplasty(CBA)prior to bare metal stenting on restenosis ―A prospective randomized multicenter trial
comparing CBA with balloon angioplasty(BA)before stenting(REDUCE Ⅲ)―, Circ. J., 71:1-8, 2007.
－ 38 －

0300B002

Y. Yamaguchi, H.Tsugawa, N.Fujioka, K.Kaseno, M.Kitayama, K.Kajinami: Role of a novel conduction patternaround the coronary sinus in cavotricuspid isthmus dependent right atrial flutter, J Cardiol, 50:1-10, 2007.

0300B003(S.Kanayama), I.Matsunari, K.Kajinami: Comparison of gated N-13 ammonia PET and gated Tc-99m sestamibi
SPECT for quantitative analysis of global and regional left ventricular function, J. Nucl. Cardiol., 14:680-687,
2007.

0300B004(N.Morikawa), Y.Kawai, K.Arakawa, T.Kumamoto, I.Miyamori, H.Akao, M.Kitayama, K.Kajinami, Jong-Dag Lee,
H.Takeshita, Y.Kominato, T.Yasuda: Serum deoxyribonuclease I activity can be used as a novel marker of transient
myocardial ischemia:results in vasospastic angina pectoris induced by provocation test, Eur. Heart J., 28:29922997, 2007.

0300B005

K.Kaseno, H.Tada, S.Ito, K.Tadokoro, T.Hashimoto, K.Miyaji, S.Naito, S.Oshima, A.Nogami, K.Taniguchi:
Ablation of idiopathic ventricular tachycardia in two separate regions of the outflow tract: prevalence andelectrocardiographic characteristics, Pacing Clin. Electrophysiol., 30(suppl1):S88-93, 2007.

0300B006(Y.Kominato), R.Iida, T.Nakajima, Y.Tajima, R.Takagi, C.Makita, K.Kishi, M.Ueki, Y.Kawai, T.Yasuda: Hypoxia
induces upregulation of the deoxyribonuclease I gene in the human pancreatic cancer cell line QGP-1, Biochim.
Biophys. Acta, 1770:1567-1575, 2007.

Case Reports
0300D001

K.Kaseno, H.Tada, S.Tanaka, K.Goto, M.Yokokawa, S.Hiramatsu, S.Naito, S.Oshima, K.Taniguchi: Successful
catheter ablation of left ventricular epicardial tachycardia originating from the great cardiac vein ―A case reportand review of the literature―, Jpn. Circ. J., 71:1983-1988, 2007.

－ 39 －

0310

Department of Respirology (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

lung physiology, sleep disordered breathing

Associate Professor

OSANAI Kazuhiro

lung cell and molecular biology , COPD

Senior Assistant Professor

HUANG Jyongsu

lung physiology, sleep disordered breathing

Senior Assistant Professor

IGUCHI Masaharu

clinical respiratory medicine

Senior Assistant Professor

TAKAHASHI Masakatsu

clinical respiratory medicine , pulmonary tuberculosis

Assistant Professor

TOBE Takeyasu

clinical respiratory medicine

Assistant Professor

TSUCHIHARA Katsuma

clinical respiratory medicine

Assistant Professor

OIKAWA Taku

clinical respiratory medicine , lung cancer

Assistant Professor

OIKAWA Rieko

clinical respiratory medicine , lung cancer

Research Associate

NAKAGAWA Kenclinical respiratory medicine , lung cancer

Assistant Professor

TACHI Yuki

clinical respiratory medicine

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, NO, matrix metalloproteinase, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic
reflection technique, upper airway compliance, CPAP, BiPAP, lung cancer, apoptosis, Fas, Fas ligand

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Apoptosis of lung cancer cells

Publications
Originals
0310B001

M.Matoba, H.Tonami, T.Kondou, H.Yokota, K.Higashi, H.Toga, T.Sakuma: Lung Carcinoma : diffusion-weighted
MR imaging-preliminary evaluation with apparent diffusion coefficient, Radiology., 243:570-577, 2007.

0310B002(A.Zippeliu), A.Gati, T.Bartnick, S.Walton, B.Odermatt, E.Jaeger, R.Dummer, M.Urosevic, V.Filonenko,
K.Osanai, H.Moch, YT.Chen, LJ.Old, A.Knuth, D.Jaeger: Melanocyte differentiation antigen RAB38/NY-MEL-1
induces frequent antibody responses exclusively in melanoma patients, Cancer Immunol. Immunother., 56:249-258,
2007.

Reviews－ 40 －

0310C002(T.Nakajima), K.Yasufuku, N.Kurimoto, H.Saka, M.Tsuboi, H.Horinouti, H.Isobe, F.Imamura, Y.Ohno, M.Sato,
T.Tsuchida, H.Toga, S.Hayashi, K.Matsui, T.Miyazawa, A.Yokoyama, H.Honda, K.Sibuya, T.Fujisawa:Endobronchial ultrasound-guided trasbronchial needle-aspiration for lymph node staging of lung cancer,
Proceedings of the Japanese Lung Cancer Society Lung cancer., 47:207-214, 2007 (in Japanese) .

0310C003(T.Nakajima), Y.Shibuya, H.Honda, F.Imamura, M.Satou, H.Isobe, Y.Ohno, T.Tsuchida, H.Toga, S.Hayashi,
K.Mastui, T.Miyazawa, A.Yokoyama, N.Kurimoto, H.Saka, M.Tsuboi, H.Horinouchi, K.Yasufuku, T.Fujisawa:Standard classification of autofluorescence bronchoscopy findings, Proceedings of the Japanese Lung Cancer
Society Lung cancer., 47:215-221, 2007 (in Japanese) .

Case Reports
0310D001

Y.Takahashi, T.Kiba, K.Yamaguchi, Y.Saitou, K.Nishio, M.Iguchi, Y.Motoo: A case undergoing repeatedanaphylactic shok after systemic administration of vinorelbine, Cancer & chemotherapy., 34:2321-2323, 2007 (inJapanese) .

Short Communications
0310E001

K.Sato, Y.Ueda, S.Katsuda, K.Tsuchihara: Myelolipoma of the lung: a case report and brief review, J. Clin.
Pathol., 60:728-730, 2007.

Presentations at Conference
International Conference (Presentations)
0310I001

K.Osanai, R.Oikawa, J.Higuchi, T.Miwa, H.Toga: Rab38-Deficient rats show phenotype o hermansky-pudlak
syndrome, ATS 2007 International conference, (San Francisco, '07.05).

－ 41 －

0320

Department of Gastroenterology

Faculty
Title

Name

Field of Specialization

Professor

TAKASE Shujiro

Gastroenterology, Hepatology

Associate Professor

KAWAHARA Hiromu

Liver injury and oxidative stressSenior Assistant Professor

TSUCHISHIMA Mutsumi

Anti-viral therapy of viral hepatitis

Assistant Professor

OKAMURA Hideyuki

Clinical feature and nutritional treatment of liver cirrhosis

Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Assistant Professor

SHIMANAKA Koshi

Clinical feature and treatment of viral hepatitis

Assistant Professor

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

Assistant
Professor(Additional Post)SHIROEDA Hisakazu

Endoscopic therapy of early gastric cancer

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

FUKURA Masayuki

Chemotherapy of advanced hepatic cancer

Assistant Professor

YANO Hirokazu

Clinico-epidemiology of alcoholic liver injury

Assistant Professor

OOTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Assistant Professor

HAYASHI Nobuhiko

Effect of alcohol on colon carcinogenesis by chemical carcinogen

Assistant Professor

YAMADA Masayoshi

Nonalcoholic steatohepatitis and oxidative stress

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis－ 42 －

Publications
Originals
0320B001

A.Fukumura, M.Tsutsumi, M.Tsuchishima, N.Hayashi, M.Fukura, H.Yano, K.Ozaki, S.Takase: Effect of theinducer of interleukin-6(ME3738) on rat liver treated with ethanol, Alcohol. Clin. Exp. Res., 31(Suppl.1):49S-53S,
2007.

0320B002

N.Hayashi, M.Tsutsumi, M.Fukura, H.Yano, M.Tsuchishima, S.Takase: Effect of chronic dietary ethanol
consumption on colonic cancer in rats induced by l,l-dimethylhydrazine, Alcohol. Clin. Exp. Res., 31(Suppl.1):72S76S, 2007.

0320B003

H.Kawahara, M.Fukura, M.Tsuchishima, S.Takase: Mutation of mitochondrial DNA in livers from patients withalcoholic hepatitis and nonalcoholic steatohepatitis, Alcohol. Clin. Exp. Res., 31(Suppl.1)54S-60S, 2007.

0320B004(J.George), M.Tsutsumi: siRNA-mediated knockdown of connective tissue growth factor prevents Nnitrosodimethylamine-induced hepatic fibrosis in rats, Gene Ther., 14:790-803, 2007.

0320B005

M.Shimada, H.Kawahara, K.Ozaki, M.Fukura, H.Yano, M.Tsuchishima, M.Tsutsumi, S.Takase: Usefulness of a
combined evaluation of the serum adiponectin level, HOMA-IR, and serum Type IV collagen 7S level to predict theearly stage of nonalcoholic steatohepatitis, Am. J. Gastroenterol., 102:1931-1938, 2007.

0320B006

Y.Yanagida, M.Tsutsumi, S.Takase: Effect of the inducer of interleukin-6, ME3738, on carbon tetrachlorideinduced hepatic fibrosis in rats, J. Kanazawa. Med. Univ., 32:133-140, 2007 (in Japanese) .

0320B007

T.Fukuyama, H.Kawahara, S.Takase: The influence of ethanol on primary cultured rat hepetocytes under
suppressed complex Ⅰ of the mitochondrial respiratory chain, J. Kanazawa. Med. Univ., 32:141-150, 2007 (inJapanese) .

0320B008

T.Saito, M.Shimada, S.Takase: Hepatic expression of adiponectin in OLETF rats with nonalcoholic steatohepatitis
induced by high-fat diet, J. Kanazawa. Med. Univ., 32:211-217, 2007 (in Japanese) .

Reviews
0320C002

M.Tsuchishima, S.Takase: The particpation of cytokine in pathogenesis of aicoholic liver disease -the particpationof cytokine in ALD, Journal of clinical and experimental medicine. Supplement., 222:655-660, 2007 (in Japanese) .

0320C003

M.Tsuchishima, S.Takase: Alcoholic liver disease, Clinic all-round Sōgō rinshō., 56:3062-3067, 2007 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0320I001

M.Shimada, T.Saitoh, K.Ozaki, M.Fukura, H.Yano, M.Tsuchishima, H.Kawahara, S.Takase: Long-term oral feadingwith a high-fat diet causes steatohepatitis and metabolic syndrome in OLETF rats, 17th Asian Pacific Association
for the Study of the Liver, (Kyoto, '07.03)，Hepatol Intern, 1:227, 2007.

0320I002

M.Shimada, T.Saitoh, K.Ozaki, M.Fukura, H.Yano, M.Tsuchishima, H.Kawahara, S.Takase: Usefulness of serum
oligometric adiponectin level to predict of nonalcoholic steatohepatitis, 17th Asian Pacific Association for the
Study of the Liver, (Kyoto, '07.03)，Hepatol Intern, 1:221, 2007.

0320I003

M.Fukura, M.Tsutsumi, Y.Yanagida, M.Tsuchishima, N.Hayashi, S.Takase: Effect of the inducer of interlenkin6(ME3738) on carbon tetrachloride induced hepatic fibrosis in rat, 17th Asian Pacific Association for the Study of
the Liver, (Kyoto, '07.03)，Hepatol Intern, 1:207, 2007.

0320I004

H.Kawahara, T.Fukuyama, M.Yamada, M.Fukura, K.Ozaki, M.Tsuchishima, S.Takase: The influence of ethanol on
the cytoskeleton of primary cultured hepatocytes under suppressed complex I of the mitochondrial respiratory
chain, 15th United European Gastroenterology Week, (Paris, '07.10).

－ 43 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

YOKOYAMA Hitoshi

Clinicopathological study of nephritic and nephrotic syndrome,
Clinical study of blood purification, Clinicopathological study ofrenal transplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Associate Professor

ASAKA Mitsuhiro

Cellular immunity in uremia, Clinicopathological study of primary
nonfunction and chronic allograft nephropathy in renaltransplantation

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology,

Assistant Professor

IMAMURA Hidetsugu

Clinical nephrology,

Assistant Professor

ADACHI Hiroki

Clinical nephrology,

Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology,

Assistant Professor

CHIKAZAWA Yoshihiro

Clinical nephrology,

Assistant Professor

NAKAGAWA Masaru

Clinical nephrology,

Assistant Professor

HAYAMA Satoshi

Clinical nephrology,

Assistant Professor

MORITA Kyoko

Clinical nephrology,

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology.

Assistant Professor

IMURA Junko

Clinical nephrology.

Associate Professor

FUJIMOTO Keiji

Clinical nephrology.

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

－ 44 －

Publications
Originals
0330B001(I.Nakaya), T.Wada, K.Furuichi, N.Sakai, K.Kitagawa, H.Yokoyama, Y.Ishida, T.Kondo, T.Sugaya, H.Kawachi,
F.Shimizu, S.Narumi, M.Haino, C.Gerard, K.Matsushima, S.Kaneko: Blockade of IP-10/CXCR3 promotes
progressive renal fibrosis, Nephron Exp. Nephrol., 107:e12-e21, 2007.

0330B002(Y.Iwata), T.Wada, H.Yokoyama, T,Toyama, S.Kitajima, T.Okumura, A.Hara, J.Yamahana, I.Nakaya, M.Kobayashi,
K.Kitagawa, S.Kokubo, K.Yoshimoto, K.Shimizu, N.Sakai, K.Furuichi, Y.Koshino, S.Takeda, K.Takasawa, S.Ohta,
M.Takaeda, C.Takaeda, S.Kaneko: Effect of sevelamer hydrochloride on markers of bone turnover in Japanese
dialysis patients with low biointact PTH levels, Intern. Med., 447-452, 2007.

Reviews
0330C001

H.Yokoyama, T.Wada, W.Zhang, H.Yamaya, M.Asaka: Advances in apheresis therapy for glomerular diseases, Clin
Exp Nephrol, 11:122-127, 2007.

0330C003

H.Yokoyama, T.Wada: Diagnoxtic approach to drug induced renal injurise, Journal of clinical and experimental
medicine. Supplement., 27-31, 2007 (in Japanese) .

0330C007

H.Yokoyama: Nephrooltic syndrome, Clinic all-round ; Sogo rinsho., 56：1337-1343, 2007 (in Japanese) .

0330C010

H.Yokoyama: Hepatitis C virus(HCV) axxociated nephritis, Nephrol. Fronti., 6：158-162, 2007 (in Japanese) .

0330C011

M.Asaka, H.Imamura, H.Yokoyama: Renalinvolvement in bronchopulmonary diseases, Clinic all-round ; Sogo
rinsho., 56:2118-2122, 2007 (in Japanese) .

0330C018

N.Tomosugi: Iron overload in renal anemia, The Japanese journal of clinical dialysis., 23:1555-1562, 2007 (inJapanese) .

Others
0330F001(H.Kawabata), N.Tomosugi, J.Kanda, Y.Tanaka, K.Yoshizaki, T.Uchiyama: Anti-interleukin 6 receptor antibody
tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease, Haematologica.,
92:857-858, 2007.

0330F004

H.Yokoyama: Clinicopathological studies of membranous nephropathy in nephrotic syndrome, Journal of the Juzen
Medical Society., 116:102-103, 2007 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0330H001

H.Yokoyama, T.Wada: Application of lymphocytapheresis for nephrotic syndrome, 6th World Congress of theInternational Society for Apheresis(ISFA) World Apheresis Association 11th Congress(WAA), (Yokohama, '07.03)，
Therapeutic Apheresis and Dialysis, 11:A23, 2007.

International Conference (Presentations)
0330I001(M.Yamazaki), T.Wada, H.Yokoyama, S.Nakao: Usefulness of immunoadsorption plasmaphaeresis using selesorbR
for catastrophic antiphospholipid syndrome:differences in plasma purification by subclass of antiphospolipid
antibodies, 6th World Congress of the International Society for Apheresis(ISFA) World Apheresis Association 11th
Congress(WAA), (Yokohama, '07.03).

0330I002

K.Kitagawa, N.Tomosugi, H.Tuchida, H.Sasaki: Automated identification and quantification of tear proteins from
Sjogern's syndrome by LC/MS on a hybrid linear ion trap mass spectrometer, 5th international Conference on the
Tear Film & Ocular Surface : Basic Science and Cliical Relevance, (Italy, '07.08).
－ 45 －

0330I003

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).

0330I004

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

0330I005(T.Saito), T.Mitarai, H.Yokoyama, N.Yorioka, M.Iwano, S.Nishi, A.Yoshimura, K.Matsumoto, H.Sato, M.Honda,
Y.Tomino: Effect of preprandial once-a-day administration of cyclosporine(CyA)for steroid resistant nephrotic
syndrome(SRNS), ASN Renal Week in San Francisco, (San Francisco, '07.11)，J.Am.Soc.Nephrol., 18:562A, 2007.

0330I006

H.Yokoyama, T.Kawaguchi, Y.Takahashi, S.Fukuhara, A.Saito: Biocompatibility and permeability of dialyzer
membrance do not affect anemia, erythropoietin dosage or mortality in Japanese patients on chronic non-reuse
hemodialysis: a prospective cohort study from the J-DOPPS II study, ASN Renal Week in San Francisco, (SanFrancisco, '07.11)，"J.Am.Soc.Nephrol,", 18:517A, 2007.

－ 46 －

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Professor

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterone secretion

Associate Professor

NAKAGAWA Atsushi pancreatic and gut hormones, pituitary diseases

Senior Assistant Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Assistant Professor

IMAIZUMI Noriko

intracellular mechanisms of aldosterone synthesis, diabetes

Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Assistant Professor

FURUYA Keisuke

diabetes, thyroid diseases

Assistant Professor

MAEJIMA Katsuyuki

diabetes, thyroid diseases

Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Assistant Professor

UEHARA Keigo

diabetes

Assistant
Professor(Additional Post)

KITADA Munehiro

diabetes, hypertension

Research Doctor

ITO Hiroki

diabetes, thyroid diseases

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

－ 47 －

Publications
Originals
0340B001(T.Uzu), M.Sawaguchi, H.Maegawa, A.Kashiwagi, K.Tomita, N.Horide, T.Kawabata, D.Koya, T.Uzu, H.Maegawa,
M.Nishimura, S.Yamada, Y.Kida, T.Hashimoto, N.Takahara, K.Egawa, M.Iwanishi, N.Harada, T.Arimura,
A.Kadota, T.Fujita, M.Ikebuchi, K.Sakamoto, Y.Nishio, S.Ugi, O.Sekine, T.Sugimoto, S.Araki, K.Isshiki,
M.Sawaguchi, N.Shirahashi, M.Haneda, A.Kashiwagi: Reduction of microalbuminuria in patients with type 2
diabetes, Diabetes Care., 30:1581-1583, 2007.

0340B002(S.Kume), M.Haneda, K.Kanasaki, T.Sugimoto, S.Araki, K.Isshiki, M.Isono, T.Uzu, L.Guarente, A.Kashiwagi,
D.Koya: SIRT1 inhibits transforming growth factor β induced apoptosis in glomerular mesangial cells via Smad7
deacetylation, J. Biol. Chem., 282:151-158, 2007.

0340B003(S.Araki), M.Haneda, D.Koya, T.Sugimoto, K.Isshiki, M.Chin-Kanasaki, T.Uzu, A.Kashiwagi: Predictive impact ofelevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study,
Diabetologia, 50:867-873, 2007.

0340B004

A.Nakagawa, K.Ueno, M.Ito, S.Okamoto, K.Uehara, H.Ito, S.Mishina, E.Kinoshita, T.Nojima, H.Takahashi,
H.Ikawa, S.Takashima, M.Nishizawa, S.Nakano, T.Kigoshi, H.Nakabayashi, K.Uchida: Insulin responses toselective arterial calcium infusion under hyperinsulinemic euglycemic glucose clamps: case studies in adultnesidioblastosis and childhood insulinoma, Endocr. J., 54:27-33, 2007.

0340B005(Y.Morita), H.Araki, T.Sugimoto, K.Takeuchi, T.Yamane, T.Maeda, Y.Yamamoto, K.Nishi, M.Asano, K.ShirahamaNoda, M.Nishimura, T.Uzu, I.Hara-Nishimura, D.Koya, A.Kashiwagi, I.Ohkubo: Legumain/asparaginyl
endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal
proximal tubular cells, FEBS Lett., 581:1417-1424, 2007.

Reviews
0340C002

D.Koya: New therapeutic strategy for diabetic nephropathy, Journal of clinical and experimental medicine.
Supplement., 220:1191-1195, 2007 (in Japanese) .

0340C005

D.Koya: Diagnosis and management of diabetic nephropathy, Clinic all-round Sōgō rinshō., 56:2078-2082, 2007 (inJapanese) .

Short Communications
0340E001(S.Araki), M.Haneda, D.Koya, H.Hidaka, T.Sugimoto, M.Isono, K.Isshiki, M.Chin-Kanasaki, T.Uzu, A.Kashiwagi:
Reduction in microalbuminuria as an integrated indicator for renal and cardiovascular risk reduction in patients with
type 2 diabetes, Diabetes, 56:1727-1730, 2007.

Presentations at Conference
International Conference (Synposium)
0340H001

M.Nishizawa: An important role of vagalpathways in incretin effect by GLP-1., 14th Japan-Korea Symposium on
Diabetes Mellitus 2007, (Kyoto, '07.10)，14th Japan-Korea Symposium on Diabetes Mellitus 2007 -Diabetes andmetabolic syndorome in Asia-, 77, 2007.

0340H002

D.Koya: Remission and regression of diabetic nephropathy and ITS perspective., 14th Japan-Korea Symposium on
Diabetes Mellitus 2007, (Kyoto, '07.10)，14th Japan-Korea Symposium on Diabetes Mellitus 2007 -Diabetes andmetabolic sindorome in Asia-, 93, 2007.

0340H003(J.Honjo), Y.Makino, K.Okamoto, D.Koya, A.Kashiwagi, M.Haneda: Cyclic amp attenuates transforming growth
factor-β(TGF-β)-inducd increase in plasminogen activator inhibitor-1(pai-1) in human renal proximal tubularepithelial cells (rptec)., 14th Japan-Korea Symposium on Diabetes Mellitus 2007, (Kyoto, '07.10)，14th JapanKorea Symposium on Diabetes Mellitus 2007 -Diabetes and metabolic sindorome in Asia-, 173, 2007.
－ 48 －

0340H004(S.Araki), H.Matsuno, M.Haneda, D.Koya, T.Uzu, A.Kashiwagi: Association between Activated platelet profile andalbuminuriain patients with type 2 diabetes mellitus., 14th Japan-Korea Symposium on Diabetes Mellitus 2007,(Kyoto, '07.10)，14th Japan-Korea Symposium on Diabetes Mellitus 2007 -Diabetes and metabolic sindorome in
Asia-, 186, 2007.

0340H005

S.Tsuda, S.Nakano, KKonishi ., D.Koya: Metabolic syndrome predicts end-stage renal disease rather than cerebral
or cardlac vascular events in japanese individuals., 14th Japan-Korea Symposium on Diabetes Mellitus 2007,(Kyoto, '07.10)，14th Japan-Korea Symposium on Diabetes Mellitus 2007 -Diabetes and metabolic sindorome in
Asia-, 187, 2007.

International Conference (Presentations)
0340I001

M.Kitada, D.Koya: Resveratrol ameliorates diabetic nephropathy in db/db mice, similar to calorie restriction., 40th
American society of Nephrology, (San Franｃiｓco, '07.10).

－ 49 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology

Professor

HIROSE Yuko

Hematology and Immunology,Transfusion Medicine

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology

Associate Professor

MASAKI Yasufumi

Hematology and Immunology

Senior Assistant Professor

TANAKA Masao

Rheumatology,Immunology

Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Assistant Professor

JIN Zhexiong

Immunology

Keywords of Research
autoimmune disorder, SjÖgren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A) Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1) Effects of chemokines on
vascular injury and Th1 response during chronic inflammation. 2) Function of microdomain (lipid rafts) on lymphocyte
activation and its contribution in autoimmune diseases. 3) Analysis of immunological disorder in sphingomyelin knockout
mice. 4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5) Detection of stem cells insalivary glands and its implication for regenerative medicine.
B) Studies of hematological malignancies and development of anti-cancer drugs. 1) Analysis of EB-virus proteins and theirroles in lymphoproliferative disorders. 2) Molecular biological analysis of drug resistance. 3) Roles of sphingomyelin on
apoptosis.

Publications
Originals
0350B001

L.Dong, Y.Masaki, T.Takegami, T.Kawanami, K.Itoh, Z.Jin, C.Huang, X.Tong, T.Fukushima, M.Tanaka, T.Sawaki,
T.Sakai, S.Sugai, T.Okazaki, Y.Hirose, H.Umehara: Cloning and expression of two human recombinant monoclonal
Fab fragments specific for EBV viral capsid antigen, Int. Immunol., 19:331-336, 2007.

0350B002

L.Dong, Y.Masaki, T.Takegami, Z.Jin, C.Huang, T.Fukushima, T.Sawaki, T.Kawanami, T.Saeki, K.Kitagawa,S.Sugai, T.Okazaki, Y.Hirose, H.Umehara: Clonality analysis of lymphoproliferative disorders in patients with
Sjögren's syndrome, Clin. Exp. Immunol., 150:279-284, 2007.

0350B003(S.Nakayamada), K.Saito, H.Umehara, N.Ogawa, T.Sumida, S.Ito, S.Minota, H.Nara, H.Kondo, J.Okada, T.Mimori,
H.Yoshifuji, H.Sano, N.Hashimoto, S.Sugai, Y.Tanaka: Efficacy and safety of mizoribine for the treatment of
Sjögren's syndrome:a multicenter open-label clinical trial, Mod Rheumatol, 17:464-469, 2007.

0350B004

L.Dong, Y.Masaki, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara: Sjögren's Syndrome and Lymphoma
Development, Curr. Immunol. Rev., 3:289-296, 2007.
－ 50 －

0350B005(K.Shimoyama), N.Ogawa, T.Sakai, T.Sawaki, T.Kawanami, H.Karasawa, Y.Masaki, M.Tanaka, T.Fukushima,
Y.Hirose, H.Umehara: Analysis of clinical significance of anti-cyclic citrullinated peptide antibody (anti-CCP
antibody) in rheumatoid arthritis(RA)., Japanese journal of clinical immunology., 30:408-413, 2007 (in Japanese) .

0350B006

T.Sawaki: Characterization of cultured minor salivary gland epithelial calls from patients with Sjögren's syndrome
expressing chemokines, J. Kanazawa. Med. Univ., 32:203-210, 2007 (in Japanese) .

Reviews
0350C006

T.Kawanami, Y.Matsuzaki, T.Sawaki, T.Sakai, Z.Jin, Y.Masaki, T.Fukushima, M.Tanaka, H.Umehara: Identificationof human salivary stem cells from cultured labial minor salivary cells, Japanese journal of clinical immunology.,
30:455-460, 2007 (in Japanese) .

Others
0350F001(T.Daniels), JS.Greenspan, DP.Cox, LA.Criswell, Y.DeSouza, Y.Dong, D.Greenspan, A.Heidenreich, S.Johansen,
R.Jprdam, K.Kitagawa, H.Lanfranchi, K.Sack, M.Schidt, C.Shiboski, S.Shiboski, S.Sugai, H.Umehara, J.Whitcher,
A.Wu, S.Zhzng: Objective measures inSjogren's syndrome are strongly associated with each other but not withsicca symptoms: Analysis of 564 enrollees in the SICCA international regikstry and repository, Arthritis Rheum.,56(Suppl.):S446, 2007.

Presentations at Conference
International Conference (Presentations)
0350I001

Y.Masaki, T.Sakai, T.Sawaki, T.Kawanami, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: ATLL&HTLV1Infection in Ishikawa,Japan., 13TH INT'L CONFERENCE ON HUMAN RETROVIROLOGY HTLV AND
RELATED VIRUSES, (Hakone, '07.05).

－ 51 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology,Neuroimmunology,Clinical Immunology

Associate
Professor(Additional Post)

HORI Ariyuki

Medical education,Clinical neurology,Clinical sleep medicine,
Neurophysiology,Medical informatics

Senior Assistant Professor

NAGAYAMA Shigeni

Clinical neurology,Neuroimmunology

Assistant Professor

KAWAMURA Kazuyuki

Clinical neurology,Neuroimmunology

Assistant Professor

NAGAISHI Akiko

Clinical neurology

Assistant Professor

NAKANISHI Megumi

Clinical neurology,Neuroimmuology

Assistant Professor

KAITO Muichi

Clinical neurology

Assistant Professor

GONDO Yuichiro

Clinical neurology

Research Associate

ARAYA Shinichi

Neuroimmunology, Clinical Immunology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001

S.Saiki, K.Sakai, K.Murata, M.Saiki, M.Nakanishi, Y.Kitagawa, M.Kaito, Y.Gondo, T.Kumamoto, M.Matsui,
N.Hattori, G.Hirose: Primary skeletal muscle involvement in chorea-acanthocytosis, Mov. Disord., 22:848-852,
2007.

Presentations at Conference
International Conference (Presentations)
0360I001(K.Murata), A.Suzuki, T.Kihira, H.Miwa, M.Matsui, T.Kondo: Analysis of Alpha-Enolase Expression in Muscle
from Patients with Inflammatory Myopathy, 132nd Annual Meeting American Neurological Association,(Washington, '07.10).

0360I002

M.Matsui: Treating NMO, 5th MS Forum Pan Asian Conference, (Taipei, '07.11).

－ 52 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Associate Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Senior Assistant Professor

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis

Senior Assistant Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

MIYAUCHI Eiji

Geriatrics, Diabetes Mellitus, Endocrinology

Senior Assistant Professor

MURAI Hiroshi

Geriatrics, Gastroenterology, Dementia, Nutrition

Assistant Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Assistant Professor

ISHIGAMI Keiichiro

Geriatrics, Hypertension, Atherosclerosis.

Research Doctor

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis

Research Doctor

OWARI Masaki

Geriatrics, Hypertension, Atherosclerosis

Research Doctor

KATO Shouzaburo

Geriatrics, Hypertension, Atherosclerosis

Faculty

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi,
K.Iwai, M.Matsumoto, T.Kanda: Oral administration of candesartan improves the survival of mice with viral
myocarditis through modification of cardiac adiponectin expression, Cardiovasc Drugs Ther, 21:155-160, 2007.

0370B002

T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto: Reduced-energy
diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, Int.
J. Cardiol., 119:310-318, 2007.

－ 53 －

Others
0370F001

S.Morimoto, T.Nakahashi, H.Orimo: The Japanese guidelines of the prevention and treatment of osteoporosis(2006 edition)(abridged), Osteopro. Jpn., 15:351-355, 2007.

0370F002

T.Kanda, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Matsumoto: Hepatocyte growth factor andvisfatin in elderly bedridden patients, J. Am. Geriatr. Soc., 55:963-965, 2007.

Presentations at Conference
International Conference (Synposium)
0370H001

M.Atsumi, T.Nakahashi, H.Murai, K.Nomura, K.Ishigami, E.Miyauchi, H.Tsuchiya, K.Iwai, S.Morimoto: Bloodpressure ｐroblems in refuge after Noto Hanto earthquake, The 8th china-japan joint hypertension symposium,(China, '07.11)，6th asian-pacific congress of hypertension 9th international syimposium on hypertension andrelated diseases abstract, 115, 2007.

0370H002

H.Murai, S.Morimoto, T.Nakahashi, K.Nomura, M.Okuro, E.Miyauchi, H.Tsuchiya, K.Iwai, M.Matsumoto: The
Relationship between senile dementia and hypertension-The Use of VSRAD, The 8th china-japan joint
hypertension symposium, (China, '07.11)，6th asian-pacific congress of hypertension 9th international syimposium
on hypertension and related diseases abstract, 116, 2007.

0370H003

T.Nakahashi, M.Atsumi, H.Murai, K.Nomura, K.Ishigami, E.Miyauchi, H.Tsuchiya, K.Iwai, M.Yamaguchi,
S.Morimoto: The effect of great earthquake on blood pressure, The 8ht china-japan joint hypertension symposium,(China, '07.11)，6th asian-pacific congress of hypertension 9th international syimposium on hypertension andrelated diseases abstract, 117, 2007.

International Conference (Presentations)
0370I001

T.Kanda, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto: Candesartan Improves
Myocardial Damage in Obese Mice with Viral Myocarditis and Induces Cardiac Adiponectin., 4th Annual
Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, (Keystone USA,'07.07)，American Heart Association, :13, 2007.

0370I002

T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, T.Kanda, S.Morimoto: Seroprevalence of Human
Metapneumovirus in Elderly Inpatients in Japan, 45th Annual Meeting of IDSA, (SanDiego USA, '07.10)，Final
Program and Abstracts, :224-225, 2007.

－ 54 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

TAKAHASHI Hiroaki

Pediatric endocrinology

Professor

KOH Eikan

Pediatric cardiology

Professor(Additional Post)

KAKINUMA HiroakiChild neurology, Inborn errors of metabolism, Clinical genetics

Senior Assistant Professor

YANASE Takuya

Pediatric hematology, Pediatric nephrology

Senior Assistant Professor

NAKAMURA Tsuneyuki Pediatric cardiology

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology

Assistant Professor

NAKAMURA Toshimi

Pediatric allergy, Pediatric immunology

Assistant Professor

ITO Masatsune

Assistant Professor

YAMAMURA Junichi

Assistant Professor

FUJIKI Takuma

Pediatric nephrology

Assistant Professor

SATO Hitoshi

Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Assistant Professor

IKEDA TomomiChild neurology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism.
Peditric Psychosomatic Disorder，Infectious Disease of Childhood，Clinical Virology，Fast and Easy Detection System for
Infectiousagent

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001

T.Nakamura, J.Yamamura, H.Sato, H.Kakinuma, H.Takahashi: Vasculitis induced by immunization with Bacillus
Calmette-Guerin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease, FEMS
Immunol. Med. Microbiol., 49:391-397, 2007.

0380B002

A.Nakagawa, K.Ueno, M.Ito, S.Okamoto, K.Uehara, H.Ito, S.Mishina, E.Kinoshita, T.Nojima, H.Takahashi,
H.Ikawa, S.Takashima, M.Nishizawa, S.Nakano, T.Kigoshi, H.Nakabayashi, K.Uchida: Insulin responses toselective arterial calcium infusion under hyperinsulinemic euglycemic glucose clamps: case studies in adultnesidioblastosis and childhood insulinoma, Endocr. J., 54:27-33, 2007.

－ 55 －

0380B004

Y.Matsue, T.Nakamura, H.Sato, C.Akita, M.Hiramatsu, T.Kito, C.Kitaoka, J.Yamamura, T.Ikeda, T.Fujiki, M.Ito,
A.Kobayashi, T.Nakamura, H.Kakinuma, E.Koh, H.Takahashi: Clinial importance of basic life support in childhood
submersion, Japanese journal of pediatrics., 60:1195-1199, 2007 (in Japanese) .

0380B006

M.Ito: Functional studies of a duplication mutation of valine at 235 by a transient expression assay in a boy with
MCT8 deficiency, J. Kanazawa. Med. Univ., 32:156-161, 2007 (in Japanese) .

0380B007

K.Sasano, H.Kakinuma, M.Hiramatsu, T.Nakamura, K.Takekawa: Current state and demand of pediatric emergency
services recognized by guardians in Ishikawa prefecture, Hokuriku Japanese Journal of Public Health., 34:29-34,
2007 (in Japanese) .

0380B008

M.Hiramatsu, T.Nakamura, H.Sato, K.Takekawa, K.Sasano, H.Kakinuma: The questionnaire survey of the current
situation in the pediatric emergency for the residents in Ishikawa prefecture, Japanese Society of Emergency
Pediatrics., 6：216-223, 2007 (in Japanese) .

Case Reports
0380D001

H.Kakinuma, A.Hori, M.Ito, T.Nakamura, H.Takahashi: An inherited disorder characterized by repeated episodesof bilateral ballism: a case report, Mov. Disord., 22:2110-2131, 2007.

－ 56 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

JIBIKI Itsuki

Shizophrenia，Epilepsy，Brain imaging，Psychopharmacology，Senile
Demenｔia，Senile Psychosis

Associate Professor

KUBOTA Takashi

Schizophrenia，Psychopharmacology，Epilepsy

Senior Assistant Professor

IWASAKI Shinzo

Psycho Physiology，Neuropsy Chology，Brain Imaging

Senior Assistant Professor

NAKAGAWA Haruo

Psycho Physiology，Psychotherapy，Senile Psychosis

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology，Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy，Clinical Psychology

Assistant Professor

ENATSU Igaku

Senile Psychosis

Assistant Professor

KAMEHIRO Maya

Psychosomatic Medison

Assistant Professor

KOIZUMI Hazuki

Clinical Psychology，Cognitive-behaviora ltherapy

Assistant Professor

KOIWA Daisuke

Brain imaging，Schizophrenia

Assistant Professor

NANNO Hisatoshi

Schizophrenia

Assistant Professor

HIROYASU Kiwamu

Molecular Psychiatry，Schizophrenia, Epilepsy

Assistant Professor

ISHIKAWA Akira

Schizophrenia，Psychopharmacology

Assistant Professor

KAWAMURA Tomomi Psychopharmacology，Neuropsychology

Assistant Professor

SHIMIZU Satoru

Ｂｒａｉｎ imaging

Assistant Professor

MASUDA Shinji

Schizophrenia

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia－ 57 －

Publications
Originals
0390B001

A.Monkawa: Study on effects of an atypical antipsychotic agent, quetiapine, on regional cerebaral blood flow with
Tc-ECD SPECT in drug-naïve or unmedicated schizophrenic patients, J. Kanazawa. Med. Univ., 32:192-202,
2007 (in Japanese) .

99m

Case Reports
0390D004

S.Kamoda, F.Enokido, I.Jibiki: Two cases of insomnia successfully treated with Yoku-kan-san, Journal of Japanese
Association of Oriental Psychosomatic Medicine., 22:62-66, 2007 (in Japanese) .

Others
0390F001

K.Hiroyasu, I.Jibiki: Expression of voltage-gated potassium ion channel gene KCNQ3 in mouse thymus,
NEUROLOGY ASIA, 12:107, 2007.

Presentations at Conference
International Conference (Presentations)
0390I001

Shinzo Iwasaki, Akira Ishikawa, Sachiko Kamoda, Itsuki jibiki: Ａ Ｃａｓｅ Diagnosed Lissauer´s Type of General
Paresis with Paralysis Attack, WPA Regional Meeting 2007 Seoul, (Seoul, '07.04)，WPA Regional Meeting 2007
Seoul, :149, 2007.

0390I002

S.Kamoda, H.Kawada, I.Jibiki: Four cases that combination therapy of donepezil and yoku-kan-san did success ofin patient with dementia, WPA Regional Meeting 2007 Seoul, (Korea, '07.04).

0390I003

Hazuki Koizumi, Itsuki Jibiki: Cognitive-behavioral therapy program for the recurrent abdominal pain in children
who refuse to attend schools, World Congress of Behavioural and Cognitive Therapies, (Spain, '07.07).

0390I004

Satoru Shimizu, Ken-ichiro Watanabe, Xudong Li, Tomomi Kawamura, Takashi Kubota, Itsuki Jibiki: Ａ Study on
Correlations Between Z-scores of VSRAD and Results of Neuropsychological Tests in Patients with Alzheimer´s
Disease, 22th Annual Meeting of the Japanese Psychogeriatric Society., (Osaka, '07.10)，Psychogeriatrics, 7:A23,
2007.

－ 58 －

0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

HIGASHI Kotaro

Oncologic Nuclear Medicine

Associate Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

Associate Professor

YOKOTA Hajime

Gastrointestinal Radiology, MR Spectroscopy

Senior Assistant Professor

OGUCHI Manabu

Radiation Therapy, Nuclear Medicine

Senior Assistant Professor

TANIGUCHI Mitsuru Cardiac Nuclear Medicine

Senior AssistantProfessor(Additional Post)

KUGINUKI Yasuaki

Senior Assistant Professor

NISHIKAWA Takahiro Nuclear Medicine, Diagnostic Imaging

Assistant Professor

OOTA Kiyotaka

Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging.

Assistant
Professor(Additional Post)

YABUNO Yoshinori

Diagnostic Imaging

Radiation Therapy

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

M.Matoba, H.Tonami, T.Kondou, H.Yokota, K.Higashi, H.Toga, T.Sakuma: Lung Carcinoma : diffusion-weighted
MR imaging-preliminary evaluation with apparent diffusion coefficient, Radiology., 243:570-577, 2007.

0400B002

H.Yokota, J.Guo, M.Matoba, K.Higashi, H.Tonami, Y.Nagao: Lactate, choline, and creatine levels measured byvitro 1H-MRS as prognostic parameters in patients with non-small-ceｌｌ lung cancer, J. Magn. Reson. Imaging.,
25:992-999, 2007.

0400B003(M.Saiki), S.Saiki, K.Sakai, I.Matsunari, K.Higashi, K.Murata, N.Hattori, G.Hirose: Neurological deficits areassociated with increased brain calcinosis, hypoperfusion, and hypometabolism in idiopathic basal ganglia
calcification, Mov. Disord., 22:1027-1030, 2007.

－ 59 －

Case Reports
0400D001

H.Yokota, M.Matoba, H.Tonami, T.Hasegawa, H.Saito, N.Kurose: Imaging findings in primary adenosquamous
carcinoma of the liver : a case report, Clin. Imaging., 31:279-282, 2007.

－ 60 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

SAKAMOTO Shigeru

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery, Respiratory surgery

Associate Professor

HIDA Kenji

Vascular surgery

Senior Assistant Professor

NAGAYOSHI Yasuhiro Cardiovascular surgery

Senior Assistant Professor

NISHIZAWA Hisateru Cardiovascular surgery

Assistant Professor

KANNO Masaaki

Cardiovascular surgery

Assistant Professor

KOBATA Takashi

Vascular surgery

Assistant Professor

HASEGAWA Hiroki

Cardiovascular surgery

Assistant Professor

NONAKA Toshimichi Cardiovascular surgery

Assistant Professor

NOGUCHI Yasuhisa

Cardiovascular surgery

Assistant Professor

KIYOSAWA Jun

Cardiovascular surgery

Research Doctor

MIZUNO Fumito

Vascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Publications
Originals
0410B001

T.Kobata, K.Hida, H.Shikata, S.Sakamoto, J.Matsubara: Comparative study of endovenous radiofrequency
obliteration and surgical stripping for saphenous varicosis examined by air plethysmography, The Japanese journalof phlebology., 18:151-156, 2007 (in Japanese) .

0410B002

J.Matsubara, N.Shiiya, A.Ishida, T.Miyata, H.Shigematsu, Y.Obitsu, T.Shindo, K.Hida, T.Ohta, M.Ando,
T.Nishibe, T.Kawasaki, T.Yasugi, T.Onohara: Current status of medication therapy for arteriosclerosis obliterans(ASO) in university hospitals in Japan, The journal of Japanese College of Angiology., 47：153-162, 2007 (inJapanese) .

－ 61 －

Case Reports
0410D001

T.Nonaka, M.Kanno, H.Shikata, S.Sakamoto, J.Matsubara, M.Kanno: A resected case of giant primary venous
aneurysm of the median antebrachial vein, The journal of Japanese College of Angiology., 47:111-116, 2007 (inJapanese) .

0410D002

H.Shikata, Y.Ueda, H.Nishizawa, K.Hida, J.Matsubara: A case of invasive group a streptococcal infection
resembling phlegmasia cerulea dolens-a case of toxic shock-like syndrome-, The Journal of the Japanese Practical
Surgeon Society., 68:1088-1092, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0410I001

T.Kobata, K.Hida, H.Shikata, S.Sakamoto, J.Matsubara: Comparative study of endovenous radiofrequency
obliteration and surgical stripping for saphenous varicosis examined by air plethysmography, World congress of theinternational union of phelebology Asian chapter meeting, (Kyoto, '07.06).

0410I002

T.Kobata: Comparative study of endovenous radiofrequency obliteration and surgical stripping for saphenous
varicosis, 8th International Congress of the Asian Society for Vascular Surgery, (China, '07.11).

－ 62 －

0420

Department of Surgical Oncology

Title

Name

Field of Specialization

Professor

TAKASHIMA Shigeki

Surgical treatment of gastrointestinal cancer - especially gastriccancer and colorectal cancer

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Senior Assistant Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Senior Assistant Professor

YOSHITANI Shinichiro Surgery of colorectal cancer

Senior Assistant Professor

TANAKA Yumiko

Surgery of colorectal cancer

Assistant Professor

SUGAYA Junichi

Surgery of gastric cancer

Assistant Professor

HASEGAWA Taisuke Surgery of hepatobiliary diseases

Assistant Professor

MUKAI Hirokado

Surgery of digestive disease

Assistant Professor

OYAMA Katsunobu

Surgery of colorectal cancer

Assistant Professor

YOKOI Miki

Surgery of digestive disease

Assistant Professor

KURODA Masatoshi

Surgery of colorectal cancer

Assistant Professor

HAYASHI Kei

Surgery of digestive disease

Faculty

Keywords of Research
gastric cancer, lymph node metastasis, colorectal cancer, hepatic metastasis, hepatic resection, pancreas cyst, cystic
tumor, interleukin 6, biliary drainage, cytokine, laparoscopic cholecystectomy, choledocholithiasis, chemotherapy,
biochemical modulation, hepatolithiasis, pancreatic injury, bile duct cancer, pancreatic cancer, panperitonitis, gallbladdercancer, tumor marker, duodenal cancer, pancreaticoduodenectomy, abdominal injury, esophageal acharasia, neoadjuvant
chemotherapy, multiple organ injury, ileus, pancreatitis, breast cancer

Outline of Research①Study on caricinogenesis of gastrointestinal cancer②Treatment of peritonitis carcinomatosa③Strategy for hematogenous metastasis④Study on usefulness of Endotoxin adsorption therapy (PMX-DHP) for acute diffuse peritonitis accompanying large
intestinal perforation⑤Clinical evaluation of reconstructive method after gastrointestinal operation

Publications
Originals
0420B001

K.Hayashi, R.Suzuki, S.Miyamoto, S.Yoshitani, H.Kohno, S.Sugie, S.Takashima, T.Tanaka: Citrus auraptene
suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice, Nutr. Cancer., 58:7584, 2007.

－ 63 －

0420B002

A.Nakagawa, K.Ueno, M.Ito, S.Okamoto, K.Uehara, H.Ito, S.Mishina, E.Kinoshita, T.Nojima, H.Takahashi,
H.Ikawa, S.Takashima, M.Nishizawa, S.Nakano, T.Kigoshi, H.Nakabayashi, K.Uchida: Insulin responses toselective arterial calcium infusion under hyperinsulinemic euglycemic glucose clamps: case studies in adultnesidioblastosis and childhood insulinoma, Endocr. J., 54:27-33, 2007.

0420B003

H.Saito, M.Kuroda, K.Matsuzawa, Y.Tanaka, T.Hasegawa, S.Yoshitani, T.Kosaka, S.Takashima: The usefulness
and limitations of PMX-DHP for the treatment of SIRS caused by lower gastrointestinal perforation, Jornal of Japan
Society for Surgical Infection., 4:181-188, 2007 (in Japanese) .

Case Reports
0420D001

H.Yokota, M.Matoba, H.Tonami, T.Hasegawa, H.Saito, N.Kurose: Imaging findings in primary adenosquamous
carcinoma of the liver : a case report, Clin. Imaging., 31:279-282, 2007.

0420D002

K.Sato, Y.Ueda, J.Sugaya, M.Ozaki, M.Hisaoka, S.Katsuda: Extrauterine endometrial stromal sarcoma withJAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor, Virchows Arch.,
450:349-353, 2007.

Presentations at Conference
International Conference (Presentations)
0420I001(S.Miyamoto), K.Hayashi, R.Suzuki, H.Kohno, S.Sugie, S.Takashima, A.Murakami, H.Ohigashi, T.Tanaka: Citrus
auraptene suppreses azoxymethane-induced colonic preneoplasia in db/db mice, 98th Annual Meeting of American
Association for Cancer Research, (Los Angeles, '07.04).

0420I002

S.Yoshitani, M.Kuroda, S.Takashima: Clinical evaluation of postperative adjuvant immunochemotherapy for elderly
patients with colorectal cancer, 42nd World congress of the international society of surgery, (Montreal, '07.08).

0420I003

S.Yoshitani, T.Hasegawa, S.Takashima: Clinical significance of peritoneal lavage cytology for colorectal cancer,
International association of surgeons, gastroenterologists and oncologists, (Bucharest, '07.09).

0420I004

S.Takashima, K.Matsuzawa, T.Hasegawa, S.Yoshitani, H.Saito: Study on usefulness of endotoxin adsorption
therapy (PMX-DHP) for acute diffuse peritonitis accompanying large intestinal perforation, nternational associationof surgeons, gastroenterologists and oncologists, (Bucharest, '07.09).

－ 64 －

0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami

Hip surgery

Associate
Professor(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

Senior Assistant Professor

FUJITA Takuya

Spinal surgery

Senior Assistant Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

YOKOYAMA Mitsuteru

Hand surgery, Trauma

Senior Assistant Professor

OKUDA Tetsuhito

Spinal surgery

Senior Assistant Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

MAEOKA Hayato

TraumaAssistant Professor

OGASAWARA Masataka Hip surgery

Assistant Professor

NOUTOMI Kenji

Joint surgery

Assistant Professor

HOSOKAWA Hidetaka

Spinal surgery

Assistant Professor

ICHISEKI Toru

Hip surgery

Assistant Professor

KITAMURA Kenji

Hip surgery

Assistant Professor

HATANO Eiju

Spinal surgery

Assistant Professor

HIROMURA Kentaro

TraumaAssistant Professor

FUKUI Kiyokazu

Hip surgery

Assistant Professor

YASUDA Yoshihito

Spinal surgery

Assistant Professor

YAMADA Kengo

Hip surgery

Assistant Professor

MIAKI Kohei

Hip surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we have been trying to elucidate the mechanism of degeneration of lumber disc. It has been reported that
apoptosis of vertebral disc cells occurs in the degenerative intervertebral disc. However, its molecular mechanism remains
to be defined. The gene expression of Bax and Bcl-2 was analyzed in degenerative intervertebral disc. As a result,mechanical stress of the disc induces apoptosis through a Bax, reducing the number of cells and the synthesis ofextracelular matrix proteins and resulting in the degeneration of the disc.
－ 65 －

Publications
Originals
0430B001

T.Okuda, T.Fujita, A.Kaneuji, K.Miaki, Y.Yasuda, T.Matsumoto: Stage-specific sagittal spinopelvic alignmentchanges in osteoarthritis of the hip secondary to developmental hip dysplasia, Spine, 32:E816-E819, 2007.

0430B004

T.Fujita, T.Okuda, E.Hatano, Y.Yasuda, T.Matsumoto: Clinical results of computer navigation-assisted minimallyinvasive TLIF (MIS-TLIF), Surgical Technique for Spine and Spinal Nerves., 9:75-78, 2007 (in Japanese) .

0430B010

J.Tomidokoro: Micro-motion of the cemented femoral stems of different surface finish in total hip arthroplasty, J.
Kanazawa. Med. Univ., 32:183-191, 2007 (in Japanese) .

Reviews
0430C001

T.Matsumoto, K.Kitamura, T.Ichiseki, A.Kaneuji, T.Sugimori: Oxidative stress on idiopathic osteonecrosis, Clin.
Calcium, 17:887-891, 2007 (in Japanese) .

Others
0430F001

T.Fujita, T.Okuda, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: Minimally invasive TLIF (MIF-TLIF) via a
unilateral approach, The journal of the Japan Spine Research Society., 18:665-668, 2007.

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

T.Matsumoto: Osteonecrosis might be preventable －The view point of oxidative stress－, The 51th Annual
Meeting of the Korean Hip Society, (GwangJu, '07.05).

International Conference (Presentations)
0430I001

A.Kaneuji, K.Yamada, T.Matsumoto, K.Hirosaki, M.Takano: Stem subsidence in polished and rough stems andmechanical effect on the cement-bone interface, 07'Asia Pacific Hip Symposium, (Singapore, '07.06).

0430I002

A.Kaneuji, K.Yamada, T.Matsumoto, K.Hirosaki, M.Takano: Stem-cement subsidence effects cement-boneinterface, 6th Asia Pacific Orthopaedic Symposium 2007 （APOS 2007）, (Bangkok, '07.06).

0430I003

T.Okuda, T.Fujita, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: The influences of osteoarthritis of the hip
joint for spino-pelvic alignment and intervertebral disc in lumbar spine, 34th Annual Meeting of the International
Society for the Study of the Lumbar Spine (ISSLS 2007), (Hong-Kong, '07.06).

0430I004

T.Okuda, T.Iseda, N.Kane-Goldsmith, Y.-W.Chang, W.Young, M.Grumet: Does Single, high-dose intraspinal
injection of chondroitinase within 1 hour after injury reduce GAGs in injured spinal cord?, Neuroscince 2007, (San
Diego, '07.11).

－ 66 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Associate Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Associate Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease

Senior Assistant Professor

TAKADA Hisashi

crebrovascular disease, head injury, interventional neurosurgery

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

SASAGAWA Yasuo

brain tumor

Assistant Professor

SIRAGA Syunsuke

general neurosurgery

Assistant Professor

MURASAKA Kenshi

general neurosurgery

Assistant Professor

YAMAMOTO Kenji

general neurosurgery

Assistant Professor

YAMAMOTO Jiro

general neurosurgery

Research Doctor

TORIGOE Keiichiro

general neurosurgery

Research Doctor

SAKAI Sotaro

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia－ 67 －

4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Case Reports
0440D001(S.Hasegawa), N.Hayashi, M.Kubo, H.Hamada, N.Kuwayama, H.Shojaku, T.Akai, S.Endou: Basal encephalocele
associated with hypoplasia of the internal carotid artery. -Case report-, Neurol. Med. Chir. (Tokyo), 47:572-575,
2007.

Others
0440F001

T.Akai: Neurodevelopment of children with single suture craniosynostosis: a review, Nervous system in children.,
32:325-327, 2007 (in Japanese) .

0440F002

T.Akai: Fully endoscopic expanded endonasal approach treating skull base lesions in pediatric patients, Nervous
system in children., 32:400-401, 2007 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0440G001

H.Iizuka, T.Iida: Clinical significance of the canal diameter of the atlas in upper cervical instability, 13th Interim
meeting of WFNS/12th Asian-Australasian congress of neurological surgeons, (Nagoya, '07.11).

International Conference (Presentations)
0440I001

T.Akai, S.Siraga, Y.Sasagawa, K.Okamoto, O.Tachibana, H.Iizuka: Diagnosis and treatment of currarino anomaly,
the 6th biennial meeting of Korea-Japan conference on spinal surgery, (Pusan Korea, '07.03).

0440I002

T.Iida, T.Akai, H.Iizuka: Surgical treatment of soinal disorgers with chronic renal failure, The 6th biennial meetingof Korea-Japan conference on spinal surgery, (Pusan Korea, '07.03).

0440I003

O.Tachibana, Y.Sasagawa, K.Torigoe, S.Siraga, K.Murasaka, K.Okamoto, T.Akai, H.Iizuka: Expression ofinterleukin-1 beta, interleukin-6 and TNF-alpha in human Rathke cleft cysts:a possi le inducer of rathke cleft
cyst-associated hypophysitis, The 5th meeting of the aisian society for neuro-oncology, (Istanbul Turkey, '07.11).

0440I004

T.Akai, K.Murasaka, S.Siraga, K.Okamoto, T.Iida, H.Takada, O.Tachibana, H.Iizuka: Ventriculo-peritoneal shuntfor children, World federation of neurological societies 13th interim meeting/12th Asian-Australasian congress ofneurological surgeons, (Nagoya, '07.11).

0440I005

T.Akai, K.Yamamoto, S.Siraga, K.Murasaka, H.Iizuka: Treatment of craniosynostosis by distraction osteogenesis,
World federation of neurological societies 13th interim meeting/12th Asian-Australasian congress of neurologicalsurgeons, (Nagoya, '07.11).

0440I006

T.Akai, S.Siraga, Y.Sasagawa, K.Okamoto, O.Tachibana, H.Iizuka: Intra-parenchymal tumor biopsy byneuroendoscope under navigation, World federation of neurological societies 13th interim meeting/12th AsianAustralasian congress of neurological surgeons, (Nagoya, '07.11).

0440I007

Y.Sasagawa, O.Tachibana, H.Yokota, K.Murasaka, S.Siraga, T.Akai, H.Tonami, H.Iizuka: Usefulness of 1H-MRS in
the diagnosis of Rathke cleft cyst, The 5th meeting of the Asian society for neuro-oncology, (Istanbul turkey,'07.11).
－ 68 －

0440I008

K.Okamoto, O.Tachibana, T.Akai, H.Iizuka: Progonstic analysis of MGMT and p53 immunohistochemical
expression in patients with glioblastoma treated in the same protocol as surgery, radiotherapy and ACNU, The 5th
meeting of the aisian society for neuro-oncology, (Istanbul Turkey, '07.11).

0440I009

T.Akai, S.Siraga, Y.Sasagawa, K.Okamoto, H.Iizuka: Intra-parenchymal tumor biopsy by neuroendoscope undernavigation, fourth world conference of the international study group of neuroendoscopy, (France, '07).

－ 69 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko

Plastic and Reconstructive Surgery

Senior Assistant Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

YOSHIDA Jun

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMAMOTO Yasunori

Plastic and Reconstructive Surgery

Assistant Professor

YAMASHITA Masanobu

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

KUROSAWA Tomoko

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

SHINOKAWA Yasuo

Plastic and Reconstructive Surgery

Assistant Professor

ENOMOTO Jin

Plastic and Reconstructive Surgery

Assistant Professor

HARASHIMA Youto

Plastic and Reconstructive Surgery

Assistant Professor

MORITA Reiji

Plastic and Reconstructive Surgery

Assistant Professor

MIYASHITA Matsuki

Plastic and Reconstructive Surgery

Assistant Professor

SATSUKI Reiko

Plastic and Reconstructive Surgery

Research Doctor

IKEDA Kenichi

Plastic and Reconstructive Surgery

Research Doctor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

－ 70 －

Publications
Originals
0450B001

R.Morita, K.Shimada, S.Kawakami: Facial protection masks after fracture treatment of the nasal bone to prevent
re-injury in contact sports, J Craniofac Surg, 18：143-145, 2007.

0450B002

K.Shimada, N.Ishikura, T.Heshiki, S.Kawakami: Treatment for chronic abscess after cranioplasty: reconstruction ofdura maters using the anterolateral tight flap with fascia lata, J Craniofac Surg, 18:1305-1308, 2007.

0450B003(T.Ueno), Y.Yamamoto, N.Osakada, A.Sakurai: Long-term results of nuss method in a child, The Japanese journalof plastic & reconstructive surgery., 50：407-414, 2007 (in Japanese) .

Reviews
0450C005

K.Shimada, S.Kawakami: Diagnosis and treatment of soft tissue sarcoma; dermatofibrosarcoma protuberance,
angiosarcoma, liposarcoma, malignant fibrous hystiocytoma, The Japanese journal of plastic & reconstructive
surgery., 50：1153-1164, 2007 (in Japanese) .

0450C006

J.Yoshida, S.Kawakami: Duble jaw fractures, The Japanese journal of plastic & reconstructive surgery., 50：12911302, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0450I001

T.Miyanaga, S.Kawakami, S.Katsuda, Y.Ueda, M.Shimasaki: Degradation and Absorption Processes of Hyaluronic
Acid Filler Injected in, 17th Japan-China Joint Meeting on Plastic Surgery, (Tokyo, '07.10).

0450I002

Y.Himi, J.Yoshida, R.Morita, A.Nishio, S.Kawakami: Philtrum ridge reconstruction with palmaris longs tendon insecondary cleft lip repair, 17thJapan-China Joint Meeting on Plastic Surgery, (Tokyo, '07.10).

－ 71 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Associate Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Senior Assistant Professor

KONUMA Kunio

Pediatric surgery, Anorectal malformations, Pediatric laringo tracheo
surgery

Senior Assistant Professor

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Assistant Professor

FUKUMOTO Hironori Pediatric surgery

Assistant Professor

OGAWA Eri

Pediatric surgery

Research Doctor

OSHIKIRI Takahiro

Pediatric surgery

Faculty

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

M.Kohno, H.Ikawa, K.Konuma, H.Masuyama, H.Fukumoto, E.Morimura: Is high amplitude propagated contraction
present after transanal endorectal pull-through for Hirschsprung's disease?, Pediatr. Surg. Int., 23:981-986, 2007.

0460B002

Y.Inoue, T.Shinka, M.Ohse, M.Kohno, K.Konuma, H.Ikawa, T.Kuhara: Changes in urinary level and configuration
ratio of D-lactic acid in patients with short bowel syndrome, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.,
855:109-114, 2007.

0460B003

A.Nakagawa, K.Ueno, M.Ito, S.Okamoto, K.Uehara, H.Ito, S.Mishina, E.Kinoshita, T.Nojima, H.Takahashi,
H.Ikawa, S.Takashima, M.Nishizawa, S.Nakano, T.Kigoshi, H.Nakabayashi, K.Uchida: Insulin responses toselective arterial calcium infusion under hyperinsulinemic euglycemic glucose clamps: case studies in adultnesidioblastosis and childhood insulinoma, Endocr. J., 54:27-33, 2007.

0460B004

K.Konuma, H.Ikawa, M.Kohno, H.Masuyama, H.Fukumoto, E.Ogawa, T.Oshikiri: Long-term follow-up for
postoperative anorectal malformations: problems in male patients of high and intermediate type, Japanese journal ofpediatric surgery ; Shoni geka., 39:1183-1191, 2007 (in Japanese) .

－ 72 －

Reviews
0460C002

H.Masuyama, T.Oshikiri, E.Ogawa, H.Fukumoto, K.Konuma, M.Kohno, H.Ikawa: Infectious complications in living
donor liver transplantation, Japanese journal of pediatric surgery ; Shoni geka., 39:1431-1437, 2007 (in Japanese) .

Case Reports
0460D001

M.Kohno, H.Ikawa, S.Okamoto, H.Fukumoto, H.Masuyama, K.Konuma: Laparoscopic repair of late-presenting
bochdalek hernia in 2 infants, Surg. Laparosc. Endosc. Percutan. Tech., 17:317-321, 2007.

－ 73 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis.

Professor

NAKAIZUMI Hiroko

Professor

KITAGAWA Kazuko

Associate
Professor(Additional Post)

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration.

Assistant Professor

NAGAI Kouta

cataract, epidemiology,

Assistant Professor

KAWAKAMI Yutaka

cataract, thyroid ocular.

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

HAGIWARA Kenta

ocular infection

Research Doctor

NAKANO Tarou

cataract

Research Doctor

YAGUCHI Hiromoto

corneal epithelium, glsucoma.

intraocular lens, strabismus amblyopia, blepharospasm, pediatric
ophthalmology.
ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics.
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 74 －

Publications
Originals
0470B001

M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki: Efficacy of α-lipoic acid against diabetic cataract inrat, Jpn. J. Ophthalmol., 51:10-13, 2007.

0470B002(K.Wake), H.Hongo, S.Watanabe, M.Taki, Y.Kamimura, Y.Yamanaka, T.Uno, M.Kojima, I.Hata, K.Sasaki:
Development of a 2.45-GHz local exposure system for In Vivo study on ocular effects, IEEE Trans. Microw.
Theory Tech., 55:588-596, 2007.

0470B003(T.Olsen), A.Arnarsson, H.Sasaki, K.Sasaki, F.Jonasson: On the ocular refractive components : the Reykjavik eye
study, Acta Ophthalmol. Scand., 85:361-366, 2007.

0470B004(A.Arnarsson), KF.Damji, T.Sverrisson, H.Sasaki, F.Jonasson: Pseudoexfoliation in the Reykjavik eye study :prevalence and related ophthalmological variables, Acta Ophthalmol. Scand., 85:822-827, 2007.

0470B005

I.Shima, S.Katsuda, Y.Ueda, N.Takahashi, H.Sasaki: Expression of matrix metalloproteinases in wound healing after
glaucoma filtration surｇery in rabbits, Ophthalmic Res., 39:315-324, 2007.

0470B006(A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa: Temperature elevation in the eye of
anatomically based human head models for plane-wave exposures, Phys. Med. Biol., 52:6389-6399, 2007.

0470B007

L.Dong, Y.Masaki, T.Takegami, Z.Jin, C.Huang, T.Fukushima, T.Sawaki, T.Kawanami, T.Saeki, K.Kitagawa,S.Sugai, T.Okazaki, Y.Hirose, H.Umehara: Clonality analysis of lymphoproliferative disorders in patients with
Sjögren's syndrome, Clin. Exp. Immunol., 150:279-284, 2007.

0470B009

Q.Jingtao, H.Sasaki, L.Zhongxin, Z.Jinsheng, W.Kaili, M.Kojima, Y.Sakamoto, R.Honda, Y.Kawakami,
Y.Yamashiro, Z.Jinsong, K.Sasaki, Japan-China Co-operative Study Group: Ｃｕｒｒｅｎｔ ｓｔａｔｕｓ ａｂｏｕｔ ｂｌｉｎｄｎｅｓｓ
ａｍｏｎｇ ｌｏｗ‐income farmers in Sanya district, hainan, China, Japanese journal of clinical ophthalmology Rinsho
ganka., 61:411-416, 2007 (in Japanese) .

0470B010

M.Fukuda, K.Yamamoto, N.Takahashi, H.Sasaki, M.Yoshikawa: Corneal disorder quantification by corneal
resistance, Journal of the eye., 24:521-525, 2007 (in Japanese) .

0470B011(K.Sasaki), H.Obata, M.Yamada, K.Miyata, K.Hirano, K.Kitagawa, S.Kinoshhita: Clinical features of secondary
corneal amyloidosis, Japanese journal of clinical ophthalmology Rinsho ganka., 61:1641-1644, 2007 (in Japanese) .

Reviews
0470C001

K.Kitagawa: Infectious keratitis among contact lens wearers -Bacterial keratitis and fungal keratitis, Journal ofJapan Contact Lens Society., 49:157-162, 2007 (in Japanese) .

Others
0470F001(T.Daniels), JS.Greenspan, DP.Cox, LA.Criswell, Y.DeSouza, Y.Dong, D.Greenspan, A.Heidenreich, S.Johansen,
R.Jprdam, K.Kitagawa, H.Lanfranchi, K.Sack, M.Schidt, C.Shiboski, S.Shiboski, S.Sugai, H.Umehara, J.Whitcher,
A.Wu, S.Zhzng: Objective measures inSjogren's syndrome are strongly associated with each other but not withsicca symptoms: Analysis of 564 enrollees in the SICCA international regikstry and repository, Arthritis Rheum.,56(Suppl.):S446, 2007.

0470F003

M.Kojima: Ultraviolet exposure as a risk factor in cataract formation, J & J, 1-2, 2007 (in Japanese) .

－ 75 －

Presentations at Conference
International Conference (Presentations)
0470I001(TE.aniels), JS.Greenspan, D.Coa, L.Criswell, Y.DeSouza, Y.Dong, D.Greenspan, R.Jordan, H.Lanfranchi, K.Sack,
M.Schiodt, C.Shhiboske, S.Shiboske, S.Sugai, H.Umehara, J.Whitcher, A.Wu, K.Kitagawa: The international
Sjogrrn's syndrome registry and repository : a major resource for future research-preliminary findings, Gordon
Research Conferences, (Ventura, '07.02).

0470I002(TE.Daniels), S.John, BDS.Greenspan, K.Kitagawa: The international Sjogren's syndrome registry and repository :a Major resource for future research -Preliminary findings, 85th General Session & Exhibition of the IADR, (Now
Orleans, '07.03).

0470I003

K.Sasaki, H.Sasaki, R.Honda, Y.Kawakami, M.Kojima, Y.Sakamoto, J.Qu, Y.Yamashiro, J.Zhang, Z.Lilu: HighPrevalence of Pterygium in the Population of a Tropical Area in China -Sanya Eye Study-, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0470I004(A.M.Arnarsson), K.F.Damji, T.Sverrisson, H.Sasaki, F.Jonasson: Prevalence of pseudoexfoliation and association
with IOP, corneal thickness, and structural optic disc parameters in the Reykjavik eye study, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0470I005

H.Sasaki, Y.Sakamoto, E.Shibuya, T.Yamaguchi, Y.Kawakami, H.Nakaizumi, K.Sasaki: Deterioration of reading
performance and ocular higher order aberration in subjects with cortical cataract, Association for Research in
Vision and Ophthalmology, (Florida, '07.05).

0470I006

K.Nagai, H.Sasaki, R.Honda, M.Kojima, Y.Sakamoto, J.Qu, K.Sasaki: Prevalence of cataract in eyes with posterior
vitreous detachment, Association for Research in Vision and Ophthalmology, (Florida, '07.05).

0470I007

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.Liu, J.Zhang, K.Sasaki: True exfoliation in chinese
population in a tropical area -The Sanya Eye Study-, Association for Research in vision and Ophthalmology,(Florida, '07.05).

0470I008

M.Fukuda, H.Sasaki: Intraocular penetration of moxifloxacin ophthalmic solution in rabbit eyes, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0470I009

M.Kojima, Y.Yamashiro, M.Hanazaw, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Investigation of frequency
specificity of ocular effects through quasi-millimeter and millimeter wave exposure, Association for Research in
Vision and Ophthalmology, (Florida, '07.05).

0470I010

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: The relationshipof axial length and three main types of cataract in the population of a tropical area of China, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0470I011(H.Wakatsuchi), M.Hanazawa, T.Sakai, S.Watanabe, M.Kojima, Y.Yamashiro, K.Sasaki, O.Hashimoto: Complex
permittivities measurements of ocular tissues in quasi-millimeter and millinmeter wave bands, Bioelectromagnetics,(Kanazawa, '07.06).

0470I012

M.Kojima, M.Hanazawa, Y.Yamashiro, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Possibility of frequency specificityof ocular effects by quasi-millimeter and, Bioelectromagnetics, (Kanazawa, '07.07).

0470I013

K.Kitagawa, N.Tomosugi, H.Tuchida, H.Sasaki: Automated identification and quantification of tear proteins from
Sjogern's syndrome by LC/MS on a hybrid linear ion trap mass spectrometer, 5th international Conference on the
Tear Film & Ocular Surface : Basic Science and Cliical Relevance, (Italy, '07.08).

0470I014

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki: Difference of ocular injury by millimetr wave exposure with different
frequency, European associatio for Vision and Eye Research, (Slovenia, '07.10).

0470I015

K.Sasaki: Cataract classification systems, a critical review, European Association for Vision and Eye Research,(Slovenia, '07.10).

0470I016

H.Sasaki: Racial differences of lens trabsoarebct orioerties, European Association for Vision and Eye Research,(Slovenia, '07.10).

－ 76 －

0470I017(T.Daniels), JS.Greenspan, D.Coa, LA.Criswell, Y.DeSouza, Y.Dong, D.Greenspan, A.Heidenreich, S.Johansen,
R.Jordan, K.Kitagawa, H.Lanfranchi, K.Sack, M.Schiodt, C.Shiboski, S.Shiboske, S.Sugai, H.Umehara, J.Whitcher,
A.Wu, S.Zhang: Objective measures in Sjogren's syndrome are strongly associated with each other but not withsicca symptome : analysis of 564 enrollees in the SICCA international registry and repository, The 71st annual
meeting of the American College of Rheumatology, (Boston, '07.11).

0470I018(J.Whitcher), A.Heidenreich, Z.Shunhua, S.Johansen, K.Kitagawa, E.Strauss, S.Pflugfelder, A.Mircheff: The SICCA
study : preliminary results from ocular examinations in 736 patients, Agenda Ocular Microbiology and Immunology
Group 41st Annual meeting, (New Orleans, '07.11).

0470I019

Y.Sakamoto, H.Nakaizumi, N.Yamamoto, M.Sakamoto, H.Sasaki, K.Sasaki: Influence of the rilring of asphericintraocular lens on the ocular higher order aberration andf the contrast sensitivity function, US-Japan Cooperative
Cataract Research Group Meeting, (Hawaii, '07.12).

0470I020

K.Nagai, H.Sasaki, R.Honda, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: Change of light scattering intensity ineyes with posterior vitreous detachment, Monzen eye study, US-Japan Cooperative Cataract Research Group
Meeting, (Hawaii, '07.12).

0470I021

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD (eyedrops) on UV-B-induced cataract in rats, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'07.12).

0470I022

M.Kojima, Y.Yamashiro, Y.Sakamoto, Y.Kawakami, H.Sasaki, K.Sasaki: Difference of cataract development bydifferent frequency in millimeter wave, US-Japan Cooperative cataract Research Group Meeting, (, '07.12).

0470I023

H.Sasaki, N.Fujita, Y.Sakamoto, M.Kojima, J.Qu, N.Yamamoto, Y.Kawakami, K.Nagai, H.Nakaizumi, K.Sasaki:
Myopia induced by retrodots and nuclear caratact, US-Japan Cooperative Cataract Research Group Meeting,(Hawaii, '07.12).

－ 77 －

0480

Department of Otolaryngology

Faculty
Title

Name

Field of Specialization

Professor

TOMODA Koichi

Associate Professor

SUZUKA Yuko

Associate Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

MURATA Hideyuki

Rhinology, Head and neck surgery, Endoscopic surgery, Computer
aided surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Senior Assistant Professor

HORIGUTI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

Assistant Professor

ISHIMASA Hiroshi

Head and neck surgery, rhinology, General otolaryngology

Assistant Professor

IWASAKI Noriko

Head and neck oncology, Immune-allergic disease, generalotolaryngology

Assistant Professor

NAKAIZUMI Toshihiko Otology, Clinical andbasic otology research

Assistant Professor

MIYAZAWA Toru

Basic otology research, Head and neck surgery

Assistant Professor

KITAMURA Miwa

Otolaryngology

Assistant Professor

SAKAI Aya

Sleep apnea, Otolaryngology

Assistant Professor

YAMADA Kanako

Audiology, Otolaryngology

Otology, Computer aided surgery, Head and Neck surgery,
Neuroimmunology
Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Keywords of Researchneurotology, otoneuro surgery, tympanoplasty, vestibular neurectomy, cochlear implant, middle ear implant, virtual
endoscopy, computer-aided surgery, endoscopic nasal surgery, laser surgery, sleep apnea & snoar surgery, skull base
surgery, head and neck tumor surgery, molecular biology, neuroimmunology, oncology, laryngology, speech rehabilitation,
acoustic neuroma surgery, navigation surgery, tele-medicine, thyroid tumor surgery, virtual education for surgery

Outline of Research
Research for 3D mobile navigation system
Central mechanism of auduological function by MEG
Restration for phonation with Provox 2 prosthesis
Clinical reserach for snoar and sleep apnea
Research for Thyroid and parathyroid gland
Inner ear molecular biology
Clinical survey for Head and Neck tumor and Oncology

Publications
Originals
0480B001

N.Yang, H.Murata, K.Tomoda: Investigation of the characteristic of the endoscope and field-of-view in endoscopic
sinus surgery., Oto-rhino-laryngology Tokyo., 50:351-354, 2007 (in Japanese) .

－ 78 －

0480B002

K.Tomoda: Current state of navigation-guided medical treatment-from the business report of guideline decision fornext-generation medical instrument., Oto-rhino-laryngology Tokyo., 50:361-364, 2007 (in Japanese) .

0480B004

N.Yang, Y.Shimode, M.Kitamura, A.Sakai, K.Yamada, H.Utida, T.Nakaizumi, Y.Suzuka, K.Tomoda, H.Takahashi,
K.Mannen, S.hatta, Y.Yada: The pollen count of Cryptomeria japonica and its relation to the direction and velocity
of wind in Utinada., Pollen allergy and prevention., 18:15-24, 2007 (in Japanese) .

Reviews
0480C004

K.Tomoda, H.Murata, Y.Shimode: Current state of navigation-guided medical treatment- From the business reportof guideline decision for next-generation medical instrument-, Journal of Japan Society for Head and Neck
Surgery., 17:85-90, 2007 (in Japanese) .

Case Reports
0480D003

M.Kitamura, H.Murata, K.Tomoda: Mycosis of the sphenoid sinus with oculomotor paralysis : a case report.,
Pract. otol., 100:197-200, 2007 (in Japanese) .

Others0480F001

K.Sato, Y.Shimode, A.Itoi, Y.Ueda, S.Katsuda: Salivary duct carcinoma of the parotid gland presenting KIT(CD117) overexpression, Histopathology, 51:114-115, 2007.

Presentations at Conference
International Conference (Key Note Lecture)
0480G001

K.Tomoda: Current status of image-guided surgery in Otorhinolaryngology, The 19th International Conference ofSociety for Medical Innovation and Technology, (Sendai, '07.11).

0480G002

K.Tomoda: Intraoperative navigation surgery in otorhinolaryngology, 24th Congress of the Pan-Pacific Surgical
Association Japan Chapter, (Honoruru, '07.11).

International Conference (Presentations)
0480I001

T.Miyazawa, SA.Batts, T.Qazi, DL.Swiderski, LA.Beyer, DE.Brough, MA.Crumling, Y.Raphael: CAR Distribution
in the auditory epithelium does not reflect adenovirus transduction pattern, 30th Mid Winter Meeting: HyattRegency Denver at Colorado Convention Center, (Denver, '07.02).

0480I002

J.Yamamoto, K.Yamada, Y.Shimode, H.Tuji, K.Tomoda: A case of parotid gland squamous cell carcinoma with lapid
metastasis, 24th Congress of the Pan-Pacific Surgical Association Japan Chapter, (Honoruru, '07.11).

0480I003

Y.Suzuka, T.Miyazawa, J.Yamamoto, K.Tomoda: Clinical Analysis of Acute Epiglottitis in 5 Years, 24th Congressof the Pan-Pacific Surgical Association, (Honoruru, '07.11).

－ 79 －

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi

Medical mycology ， Dermatomycosis

Associate Professor

TANABE Hiroshi

Medical mycology, Decubitns

Senior Assistant Professor

WATANABE Seiji

Medical mycology

Senior Assistant Professor

KAWASAKI Masako

Medical mycology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Assistant Professor

TAKEDA Kiminobu

Medical mycology

Assistant Professor

TACHIKAWA Nobuyuki

Medical mycology

Assistant Professor

WAKAMATSU Nobuhiko Dermatopathology

Assistant Professor

FUJITA Jun

Medical mycology

Assistant Professor

HASEI Maki

Skin tumor and growth factores，Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartyping, electron microscopy, dermatopathology, skin tumor, decubitus, deep tissue injury

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Publications
Originals
0490B001

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, J.S.Choi: Molecular epidemiology of Trichophyton
tonsurans isolated in Japan using RFLP analysis of non-transcribed spacer regions of ribosomal RNA genes, Jpn. J.
Infect. Dis., 60：188-192, 2007.

－ 80 －

0490B002

M.Yanagihara, K.Takeda, H.Tanabe, S.Abe, H.Ishizaki: Follicular keratosis of the chin treated with 1.24Rdihydroxyvitamin D3 ointment, Pediatr. Dermatol., 24：412-414, 2007.

Case Reports
0490D001(H.Fujii), M.Tanioka, M.Yonezawa, A.Arakawa, Y.Matsumura, S.Kore-eda, Y.Miyachi, S.Tanaka, Herpes zoste: A
case of atypical sporotrichosis with multifocal cutaneous ulcers, Clin. Exp. Dermatol., 33：135-138, 2007.

0490D005(S.Okada), T.Masu, T.Tsunoda, M.Kawasaki, T.Mochizuki, R.Okuyama, S.Aiba: A case of Phaeohyphomycosis
infected with Exophiala jeanselmei, Nishinihon j. dermatol., 69：162-164, 2007 (in Japanese) .

0490D010(S.Fujita), T.Mochizuki: A case of black dot ringworm on the right forearm caused by Trichophyton tonsurans, The
Japanese Society for Medical Mycology., 48：91-95, 2007 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0490G001

M.Kawasaki: Molecular biology and black fungi around the world, 21st World Congress of Dermatology, (Buenos
Aires., '07.10).

International Conference (Synposium)
0490H001

M.Kawasaki, H.Ishizaki: Global molecular biology and Sporothrix schenckii, 21st World Congress of Dermatology,(Buenos Aires., '07.10).

International Conference (Presentations)
0490I001

M.Terada, J.Fujita, S.Watanabe, H.Tanabe, M.Kawasaki, T.Mochizuki: A case of hyalohyphomycotic cyst caused
by Fusarium solani, 21st World Congress of Dermatology, (Buenos Aires., '07.10).

－ 81 －

0500

Department of Urogenital Surgery

Faculty
Title

Name

Field of Specialization

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Associate Professor

TANAKA Tatsuro

kidney transplantation, endourology

Associate Professor

MIYAZAWA Katsuhito

kidney stone disease, endourology, prostate cancer

Senior Assistant Professor

KAWAMURA Kenjikidney stone disease, urogenital cancer

Senior Assistant Professor

MORIYAMA Manabu

kidney transplantation， kidney stone disease

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

CHIKAZAWA Ippei

general urology

Assistant Professor

TOKUNAGA Kousuke

general urology

Assistant Professor

TACHIBANA Hiromichi

general urology

Assistant Professor

ISHII Takeo

general urology

Assistant Professor

MORITA Nobuyo

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001

N.Ainoda, H.Onishi, Y.Ueda, A.Hori, K.Miura, K.Miyazawa, K.Suzuki: Increase in knowledge of ignorance during
problem-based learning sessions:possible improvement of metacognition, Medical education (Japan)., 38:11-17,
2007.

0500B002

M.T.Moriyama, K.Miyazawa, K.Noda, M.Oka, M.Tanaka, K.Suzuki: Reduction in oxalate-induced renal tubularepithelial cell injury by an extract from Quercus salicina Blume/Quercus stenophylla Makino, Urol. Res., 35:295300, 2007.

0500B003

K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki: Dietary
β-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male
ICR mice, Oncol. Rep., 17:297-304, 2007.

－ 82 －

Case Reports
0500D001

K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki: Prostate cancer producing
carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, J.
Kanazawa. Med. Univ., 32：29-31, 2007.

Others
0500F001

K.Sato, H.Tachibana, S.Morinaga, Y.Ueda, S.Katsuda: Sertoli cell tumor of the testis, not otherwise specified,presenting extensive hemorrhage and overexpression of α-methylacyl-CoA racemase (AMACR/P504S), VirchowsArch., 450:361-363, 2007.

Presentations at Conference
International Conference (Presentations)
0500I001

K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki: Dietarybeta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis inmale ICR mice, The 22nd Annual EAU Congress, (Berlin, '07.03).

－ 83 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

Professor

MAKINODA Satoru

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines

Senior Assistant Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Assistant Professor

INOUE Hirokazu

perinatal medicine, perinatal diagnosis

Assistant Professor

SASAKURA Chihaya

perinatal medicine, perinatal diagnosis

Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine

Research Doctor

KUWAHARA Takashi perinatal medicine

Research Doctor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 84 －

Publications
Originals
0510B001(H.Negishi), C.Ikeda, Y.Nagai, A.Satoh, Y.Kumasako, S.Makinoda, T.Ustunomiya: Regulation of amphiregulin,
EGFR-like factor expression by hCG in cultured human granulosa cells, Acta Obstet. Gynecol. Scand., 86:706710, 2007.

Presentations at Conference
International Conference (Synposium)
0510H001

S.Makinoda: Ovarian blood flow measurement and its clinical application, 1st Sahlgrenska Metting on Reproductive
Medicine and Gynecology, (Goteborg, '07.03).

International Conference (Presentations)
0510I001

R.Fujii: Possible involvement of interleukin-6 human luteolysis, 1st Sahlgrenska Metting on Reproductive Medicine
and Gynecology, (Goteborg, '07.03).

0510I002

S.Makinoda: Effective treatment using Granulocyte colony-stimulating factor(G-CSF) for luteinized unruptured
follicle(LUF), Intrenational Federation of Fertility Societies XIX World Congress on Fertility & Sterility, (Durban,'07.05).

0510I003

R.Fujii: Possible involvement of interleukin-6 in human luteolysis, Intrenational Federation of Fertility Societies
XIX World Congress on Fertility & Sterility, (Durban, '07.05).

0510I004

H.Inoue, T.Kuwahara, T.Waseda, T.Iura, S.Makinoda: Analysis of the hemodynamics of fetal renal artery and fetal
renal volume during the normal course of pregnancy., 17th World Congress on Ultrasound in Obstetrics andGynecology, (Florence, '07.10)，Ultrasound in Obstetrics & Gynecology, 30:629, 2007.

0510I005

C.Sasakura, H.Inoue, S.Fujita, T.Waseda, H.Tomizawa, Y.Watanabe, S.Makinoda: The usefulness of MRI in the
diagnosis of fetal lung maturity, 17th World Congress on Ultrasound in Obstetrics and Gynecology, (Florence,'07.10)，Ultrasound in Obstetrics & Gynecology, 30:566, 2007.

0510I006

R.Fujii, H.Inoue, T.Waseda, Y.Watanabe, S.Makinoda: G-CSF as the supportive drug in ovulation induction for
LUF, The International Ovarian Conference 2007, (Hakone, '07.11).

0510I007

T.Waseda, Y.Watanabe, H.Tomizawa, R.Fujii, S.Makinoda: An attempt to evaluate the placental function by using
myometrial blood flow analysis, 14th World Congress on Gestational Trophoblatic disease, (Fukuoka, '07.11).

0510I008

Y.Watanabe, C.Sasakura, H.Inoue, S.Fujita, T.Waseda, H.Takagi, H.Tomizawa, S.Makinoda: The Usefulness of
MRI in the diagnosis of fetal lung maturity, 39th International Congress Pathophysiology of Pregnancy, (Singapore,'07.11).

－ 85 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular Effects of Anesthetics, Intravenous Anesthetics

Associate Professor

SEKI Sumihiko

Vascular Reactivity and Cellular calcium dynamics

Senior Assistant Professor

SHIRAISHI Miharu

Cardiac Anesthesia, Cardiovascular Agents

Assistant Professor

SHIMO Tomohiro

Anaphylaxis

Assistant Professor

FUKUOKA Tadashi

Intensive care

Assistant Professor

HORIUCHI Katsura

General anesthesia, Local anesthesia

Assistant Professor

KARASAWA Noriyuki Ａｎａｐｈｙｌａｘｉｓ

Assistant Professor

YAMAOKA Yuko

General anesthesia, Local anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, paraquat, sepsis, delayed neuronal death, apoptosis, inducible nitric oxide synthase, brainischemia, epidural blockade, cytochrome P-450, liver mitochondoria, nitric oxide, hypothermia

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined 1) the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole, and 2) the effects of transient forebrain ischemia on
apoptotic death of the hippocampal pyramidal neuron in Mongolian gerbil.

Publications
Originals
0520B001

S.Sugiura, S.Seki, K.Hidaka, M.Shiraishi, H.Tsuchida: The hemodynamic effects of landiolol, an ultra-short-acting
beta1-selective blocker, on endotracheal intubation in patients with and without hypertension, Anesth. Analg.,
104:124-129, 2007.

0520B002

T.Shibamoto, T.Shimo, S.Cui, W.Zhang, H.Takano, Y.Kurata, H.Tsuchida: The roles of mast cells and Kupffer
cells in rat systemic anaphylaxis, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293:R2202-R2209, 2007.

0520B003

N.Karasawa, T.Shibamoto, S.Cui, H.Takano, Y.Kurata, H.Tsuchida: Hepatic pre-sinusoidal vessels contract inanaphylactic hypotension in rabbits, Acta Physiol. Scand., 189：15-22, 2007.

0520B004(K.Nakazawa), Y.Okuda, Y.Saito, S.Saito, K.Sakaida, T.Yuki, H.Ohara, H.Tsuchida, Y.Kanmura, E.Inada: A
Nationwide questionnaire survey of anesthesiology in undergraduate medical education in Japan, The Japanesejournal of anesthesiology., 56:348-356, 2007 (in Japanese) .

0520B005

S.Sugiura: Vasoreactive changes to α -adrenergic stimulation in the small mesenteric arteries of septic rat, J.
Kanazawa. Med. Univ., 32:162-169, 2007 (in Japanese) .

－ 86 －

Case Reports
0520D001

K.Hidaka, S.Nishiike, S.Sugiura, S.Seki, H.Tsuchida: Comparative clinical study of three airway devices:
ProsealTM, Cobra TM, and Softseal TM, Journal of clinical anesthesia., 31:1129-1133, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0520I001

Sugiura.S, Hidaka.K, Seki.S, Tsuchida.H: Comparative study of two beta adrenergic antagonists on hemodynamics
at the endotracheal intubation, Annual Meeting of the American Society of Anesthesiologists, (San Fransisco,'07.10).

－ 87 －

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

YOSHMURA Hiroshi

temporomandibular joint disorders, stomatology, neuroscience

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

Senior Assistant Professor

DEMURA Noboru

orthodontics, stomatology

Assistant Professor

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology

Assistant Professor

NAGAO Toshikazu

temporomandibular joint disorders, stomatology

Assistant Professor

NISHIURA Rie

temporomandibular joint disorders, stomatology

Assistant Professor

HONJOU Miho

Orthodontics.

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0530B001

K.Kaneyama, N.Segami, S.Tsurusako, K.Fujimura, J.Sato, T.Nagao: Anchored disc phenomenon with a normally
positioned disc in the temporomandibular joint: characteristics and behaviour, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 45:279-283, 2007.

0530B002

K.Kaneyama, N.Segami, J.Sato, K.Fujimura, T.Nagao, H.Yoshimura: Prognostic factors in arthrocentesis of thetemporomandibular joint: comparison of bradykinin, leukotriene B4, prostaglandin E2, and substance P level insynovial fluid between successful and unsuccessful cases, J. Oral Maxillofac. Surg., 65:242-247, 2007.

0530B003

J.Sato, N.Segami, M.Nishimura, Y.Yoshitake, K.Kaneyama, Y.Kitagawa: Expression of interleukin 8 in synovial
tissues in patients with internal derangement of the temporomandibular joint and its relationship with clinicalvariables, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 103:467-474, 2007.

0530B004

J.Sato, N.Segami, Y.Yoshitake, K.Kaneyama, H.Yoshimura, K.Fujimura, Y.Kitagawa: Specific expression ofsubstance P in synovial tissues of patients with symptomatic,non-reducing internal derangement of thetemporomandibular joint: comparison with clinical findings, Br J Oral Maxillofac Surg, 45:372-377, 2007.
－ 88 －

0530B005

K.Kaneyama, N.Segami, J.Sato, H.Yoshimura, R.Nishiura: Expression of receptor activator of nuclear factor-κB
ligand in synovial tissue: comparison with degradation of articular cartilage in temporomandibular joint disorders,
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 104:e12-e17, 2007.

0530B006

H.Yoshimura, Y.Mashiyama, K.Kaneyama, T.Nagao, N.Segami: Opening of shotcut circuits between visual andretrosplenial granular cortices of rats, Neuroreport., 18:1315-1318, 2007.

0530B007

W.Sun: Detection of bacterial DNA in synovial fluids of patients with temporomandibular joint disorder by
sequencing analysis, J. Kanazawa. Med. Univ., 32-176-181, 2007.

0530B008

Y.Mashiyama: Roles of teeth and tooth-related organs during developmental periods in the maturation ofcytoarchitecture in oral sensory cortex, J. Kanazawa. Med. Univ., 32:151-155, 2007 (in Japanese) .

0530B009

T.Sugai, R.Yamamoto, H.Yoshimura, N.Kato: Signal propagation between the piriform cortex and the endopiriform
nucleus in the rat horizontal slice preparation., The Japanese journal of taste and smell research., 14:521-522,
2007 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0530H001

N.Segami: Arthroscopic eminoplasty, 18th International Conference on Oral & Maxillofacial Surgery, (Bagalore,
India, '07.11).

－ 89 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency,Emergency medical syctem,Disaster Medicine,

Senior Assistant Professor

MASHIBA Satoru

Emergency,Anaphylaxis

Assistant Professor

HAYASHI Nobuyuki

Emergency,

Assistant Professor

MORITA Hideki

Emergency,

Assistant Professor

GOTO Tetsuro

Emergency,

Assistant Professor

NAKATA Mari

Emergency,

Assistant Professor

MIZUNUMA Mariko

Emergency,

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 90 －

0560

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical oncology, Gastroenterology, Pancreatology

Senior Assistant Professor

NAKAJIMA Hideo

Medical oncology, Immunology

Assistant Professor

SHIMASAKI Takeo

Medical oncology, Gastroenterology, BioInformatics

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0560B001(J.Pei-hong), Y.Motoo: Expression of interleukin-22 in human melanoma cell line.(in Chinese), J. Clin.
Dermatology., 36:346-347, 2007.

0560B002(W.Mai), K.Miyashita, A.Shakoori, B.Zhang, Z.Wei Yu, Y.Takahashi, Y.Motoo, K.Kawakami, T.Minamoto:Detection of active fraction of glycogen synthase kinase 3β in cancer cells by nonradioisotopic in vitro kinase
assay, Oncology, 71:297-305, 2007.

0560B003(A.Ujike-Asai), A.Okada, Y.Du, M.Maruyama, X.Yuan, F.Ishikawa, Y.Motoo, K.Isobe, H.Nakajima: Large defectsof type l allergic response in telomerase reverse transcriptase knockout mice, J. Leukoc. Biol., 82:429-435, 2007.

0560B004

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A kampo medicine, boi-ogi-to,
inhibits obesity in ovariectomized rats, eCAM, 1-9, 2007.

0560B005(M.Gironella), M.Seux, M-J.Xie, C.Cano, R.Tomasini, J.Gommeaux, S.Garcia, J.Nowak, ML.Yeung, K-T.Jeang,
A.Chaix, L.Fazli, Y.Motoo, Q.Wang, P.Rocchi, A.Russo, M.Gleave, J-C.Dagorn, JL.Iovanna, A.Carrier, MJ.Pébusque, NJ.Dusetti: Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its
restoration inhibits pancreatic tumor development., Proc. Natl. Acad. Sci. U.S.A., 104:16170-16175, 2007.

0560B006(S-B.Su), M-J.Xie, N.Sawabu, Y.Motoo: Suppressive effect of herbal medicine saikokeishito on acinar cell
apoptosis in rat spontaneous chronic pancreatitis, Pancreatology., 7:28-36, 2007.

0560B007(D.Closa), Y.Motoo, JL.Iovanna: Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.,
World J. Gastroenterol., 13:170-174, 2007.

0560B008

T.Shimasaki, Y.Ishigaki, T.Minato, Y.Motoo: Apoptosis-related gene expression profile is changed by gemcitabine
in pancreatic cancer cell line(PANC-1), The Journal of Japan Pancreas Society., 22:14-20, 2007 (in Japanese) .

－ 91 －

Reviews
0560C002

H.Nakajima: Molecular basis of self recognition in immune system, J. Kanazawa. Med. Univ., 32:23-28, 2007 (inJapanese) .

Case Reports
0560D001

Y.Takahashi, T.Kiba, K.Yamaguchi, Y.Saitou, K.Nishio, M.Iguchi, Y.Motoo: A case undergoing repeatedanaphylactic shok after systemic administration of vinorelbine, Cancer & chemotherapy., 34:2321-2323, 2007 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
0560H001

Y.Motoo, T.Shimasaki, T.Minamoto: Gemcitabine changes the gene expression of human pancreatic cancer cells :search for new therapeutic molecular targeting, NATO Advanced Research Workshop, (Tashkent,Uzbekistan,'07.09).

0560H002

H.Nakajima: Various therapies, Japan-Taiwan Joint Symposium on Medical Oncology, (Uchinada, '07.10).

0560H003

Y.Motoo, I.Arai, I.Hyodo, K.Tsutani: Introduction of GRADE Profiler （GRADEpro）., Meeting on Development of
Evidence-based Clinical Practice Guidelines in Traditional Medicines 2007 supported by WHO, (Hong Kong,'07.12).

International Conference (Presentations)
0560I001

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).

0560I002

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

0560I003

J.Moriya, J.Yamakawa, Y.Motoo, T.Takahashi, T.Kanda: Effect of Hochuekkito(Bu Zhong Yi Qi Tang)on Physical
Activity of Murine Model of Chronic Fatigue Syndrome., The14th International Congress of Oriental Medicine,(Taiwan, '07.12).

0560I004

J.Yamakawa, J.Moriya, Y.Motoo, T.Takahashi, F.Yoshizaki, T.Kanda: A Kampo Medicine, Boiogito(FangyiHuangqi-Tang), Inhibits Obesity in Ovariectomized Rats., The14th international Congress of Oriental Medicine,(Taiwan, '07.12).

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0610

Health Management Center

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Yoshiro

Glossary of Gastroenterology, Hepatology.

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

YASUDA Yukio

evidence-based health care

Professor(Additional Post)

YAMADA Yuichi

Occupational health, Epidemiology for cardiovascular and pulmonary
diseasesProfessor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

MIURA Katsuyuki

Cardiovascular epidemiology, preventive cardiology, clinicalepidemiology

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

Senior Assistant Professor

HAYASE Mitsuru

Infectious disease, Clinical Microbiology.

Senior Assistant Professor

KUGINUKI Yasuaki

hemodynamics

Assistant Professor

KUSAKA Kazuya

Radiology

Assistant Professor

YABUNO Yoshinori

Diagnostic Imaging

Assistant Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0610B001(W.Teeyakasem), M.Nishijo, R.Honda, S.Satarug, W.Swaddiwudhipong, W.Ruangyuttikarn: Monitoring of cadmium
toxicity in a Thai population with high-level environmental exposure, Toxicol. Lett., 169:185-195, 2007.

0610B002

S.Yoneyama, K.Miura, S.Sasaki, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Dietaryintake of fatty acids and serum C-reactive protein in Japanese, J Epidemiol, 17:86-92, 2007.

0610B003(T.Tanaka), T.Okmura, Z.Yamagata, T.Takebayashi, U.Tamura, Y.Kusaka, S.Urano, Y.Miyoshi, A.Okayama,
H.Ueshima, HIPOP-OHP Research Group, H.Nakagawa, K.Miura: Awareness and ｔreatment of hypertension andhypercholesterolemia in Jpanese workers:the high-risk and population strategy for occupational healthpromotion(HIPOP-OHP)study, Hypertens. Res., 30:921-928, 2007.

－ 93 －

0610B004

A.Nasermoaddeli, K.Miura, A.Matsumori, Y.Soyama, Y.Morikawa, A.Kitabatake, Y.Inaba, H.Nakagawa: Prognosis
and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study,
Heart, 93:711-715, 2007.

0610B005(Y.Hayashino), S.Fukuhara, Y.Suzukamo, T.Okamura, T.Tanaka, H.Ueshima, HIPOP-OHP Research Group,
H.Nakagawa, K.Miura: Relation between sleep qality and quwantity,quality of life, and risk of developing diabetes inhealthy workers in Japan: the high-risk and population strategy for occupational health promotion(HIPOPOHP)study, BMC Public Health., 7:129, 2007.

0610B006(The Emerging Risk Factors Collaboration.), H.Nakagawa, K.Miura: The emerging risk factors collaboration:
analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104
prospective studies of cardiovascular diseases, Eur. J. Epidemiol., 22:839-869, 2007.

0610B007

M.Nishijo, J.Kuriwaki, E.Hori, K.Tawara, H.Nakagawa, H.Nishijo: Effects of materinal exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behiavioral development in offspring rats,
Toxicol. Lett., 173:41-47, 2007.

0610B008

M.Sakurai, T.Takamura, T.Ota, H.Ando, H.Akahori, K.Kaji, M.Sasaki, Y.Nakanuma, K.Miura, S.Kaneko: Liversteatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease, J. Gastroenterol.,
42:312-317, 2007.

0610B009(Y.Suwazono), E.Kobayashi, M.Dochi, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa:
Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in
the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia, Clin. Exp.
Med., 7:108-114, 2007.

0610B010

Y.Morikawa, H.Nakagawa, K.Miura, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa: Effect ofshift work on body mass index and metabolic parameters, Scand. J. Work Environ. Health, 33:45-50, 2007.

0610B011

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

Short Communications
0610E001(T.Kido), S.Maruzeni, H.Suzuki, Y.Odamae, M.Muranaka, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa,
TM.Hung, LTH.Thom, PT.Dung, DD.Nhu, H.Oka, K.Noguchi: Five years studies on the long term effects ofwaragent orange/dioxin on human health in Vietnam, Organohalogen Compounds., 69:572-575, 2007.

0610E002(M.Muranaka), T.Kido, Y.Odamae, H.Suzuki, R.Naganuma, H.Nakagawa, M.Nishijo, K.Tawara, TM.Hung,
LTH.Thom, PT.Dung, DD.Nhu: An epidemiological study on health effects by dioxin in Vietnam; comparison ofvisual acuity of junior high school students between herbicide sprayed and non-sprayed areas, Organohalogen
Compounds., 69:2035-2038, 2007.

0610E003

K.Tawara, M.Nishijo, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, TM.Hung, LTH.Thom, PT.Dung, DD.Nhu:
Association of having birth defect chiledren with serum dioxin levels in Vietnam, Organohalogen Compounds.,
69:568-571, 2007.

0610E004

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pam, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)disturbed development of taste preference in rat offspring,
Organohalogen Compounds., 69:1809-1812, 2007.

0610E005

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, Organohalogen Compounds., 69-2031-2034,
2007.

－ 94 －

Presentations at Conference
International Conference (Synposium)
0610H001

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, 27th International symposium on halogenatedpersistent organic pollutants, (Tokyo, '07.08).

0610H002(K.Nambunmee), T.Pham-The, R.Honda, M.Nishijo, K.Miura, H.Nakagawa, W.Rungyuttikarn: Association of renal
tubular injury and bone resoption induced by cadmium expusure of inhabitants living in polluted area, Maesot
district, Tak province, Thailand, 6th Annual congress of Asia Pacific association of medical toxicology, (Bangkok,'07.12).

0610H003(T.Pham-The), K.Nambunmee, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow up study about
effects of cadmium (Cd) on renal functions among Japanese population living in a non-polluted area, 6th Annual
congress of Asia Pacific association of medical toxicology, (Bangkok, '07.12).

International Conference (Presentations)
0610I001

K.Miura, A.Matsumori, Y.Morikawa, Y.Inaba, M.Nagai, H.Nakagawa: Predictive Score to Predict the Prognosis of
Cardiomyopathies: from a Nationwide Study in Japan, 1st International Congress of Cardiomyopathy and Heart
Failure, (Kyoto, '07.03).

0610I002

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pham, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbed development of taste preference in rat off-springs, 27th
International symposium on halogenated persistent organic pollutants, (Tokyo, '07.08).

0610I003

Pham-The T, Nambunmee K, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow-up study (from 1998
to 2006) about effects of cadmium on renal functions among Japanese population living in a non-polluted area., 6th
Annual Congress of Asia-Pacific Association of Medical Toxicology, (Bangkok, '07.12).

－ 95 －

0620

Department of Pathology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MINATO Hiroshi

Anatomical pathology, Laboratory medicine, Pathological study of
pulmonary and mediastinal lesion, Pathological study of head & necktumor.

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

Research
Associate(Additional Post)
Research
Associate(Additional Post)

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Outline of Research
1.Anatomical pathology, Laboratory medicine, Pathological study of pulmonary and mediastinal lesion, Pathological study ofhead & neck tumor.
2.cellular pathology.
3.molecular pathology.

Publications
Case Reports
0620D001

K.Sato, T.Terauchi, M.Nakano, M.Takenaka, Y.Asakura, N.Kurose, T.Nojima, Y.Ueda: A case of urothelial
carcinoma of the urinary bladder presenting intracytoplasmic lumina, J. Jpn. Soc. Clin. Cytol., 46:48-52, 2007 (inJapanese) .

0620D002

K.Sato, M.Takenaka, T.Terauchi, M.Nakano, Y.Asakura, T.Nojima, Y.Ueda, S.Katsuda: A case of thyroid
adenomatous nodule with bizarre nuclei, J. Jpn. Soc. Clin. Cytol., 46:149-152, 2007 (in Japanese) .

0620D003

T.Terauchi, M.Takenaka, Y.Asakura, M.Nakano, K.Sato, M.Sagawa, N.Kurose, T.Nojima: Pulmonary pleomorphic
carcinoma: two-case report, J. Jpn. Soc. Clin. Cytol., 46：227-231, 2007 (in Japanese) .

－ 96 －

0630

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase,Diabetes Mellitus,Mental distase

Associate Professor

TAKAHASHI Takashi

Assistant
Professor(Additional Post)

KUSAKA Kazuya

Assistant Professor

YAMAKAWA Junichi

General medicine,Kampo medicine

Assistant Professor

MORIYA Junji

General medicine,Kampo medicine

Infectious diseases,Respiratory diseases,Clinicalmicrobiology,Infection control
Diaqnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer, earygastric cancer, eary colon cancer

Keywords of Researchcardiology, neurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity,
cytokine, infection

Outline of Research
Three major investigations are proceeded. One is to investigate thetherapeutic implication of cytokine against viral myocarditis, chronic
fatigue syndrome, infection due to obese through immunomodulation. The
second is to apply the kampo
medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

N.Yamaguchi, T.Takahashi, M.Sakuma, T.Sugita, K.Uchikawa, S.Sakaihara, T.Kanda, M.Arai, K.Kawakita:
Acupuncture regulates leukocyte subpopulations in human peripheral blood, Evid Based Complement Alternat
Med, 4:447-453, 2007.

0630B002

S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi,
K.Iwai, M.Matsumoto, T.Kanda: Oral administration of candesartan improves the survival of mice with viral
myocarditis through modification of cardiac adiponectin expression, Cardiovasc Drugs Ther, 21:155-160, 2007.

0630B003

T.Kanda, S.Saegusa, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto: Reduced-energy
diet improves survival of obses KKAy mice with viral myocarditis:induction of cardiac adiponectin expression, Int.
J. Cardiol., 119:310-318, 2007.

0630B004(H.Sumino), S.Ichikawa, S.Kusama, T.Takahashi, H.Sakamoto, H.Kumakura, Y.Takayama, T.Kanda, M.Murakami,
M.Kurabayashi: Relationship between brachial arterial endothelial function and lumber spine bone mineral density
in postmenopausal women, Circ. J., 71:1555-1559, 2007.

0630B005

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A kampo medicine, boi-ogi-to,
inhibits obesity in ovariectomized rats, eCAM, 1-9, 2007.

0630B006(M.Goto), T.Yamashita, S.Misawa, T.Komori, K.Okuzumi, T.Takahashi: Current biosafety in clinical laboratories inJapan: report of questionnaires' data obtained from clinical laboratory personnel in Japan, Kansenshogaku Zasshi.,
81：39-44, 2007 (in Japanese) .

－ 97 －

0630B007(T.Tanaka), M.Goto, K.Okuzumi, A.Yoneyama, T.Matsumoto, K.Yamaguchi, T.Takahashi: Isolation andidentification of Helicobacter cinaedi and H.cinaedi-like organisms isolated from blood culture in practicallaboratory procedures, Kansenshogaku Zasshi., 81：700-706, 2007 (in Japanese) .

Case Reports
0630D001

K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki: Prostate cancer producing
carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, J.
Kanazawa. Med. Univ., 32：29-31, 2007.

Others
0630F001

T.Takahashi, T.Kanda, N.Yamaguchi: Influenza Vaccines, N. Engl. J. Med., 356:1172-1173, 2007.

0630F002

T.Kanda, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Matsumoto: Hepatocyte growth factor andvisfatin in elderly bedridden patients, J. Am. Geriatr. Soc., 55:963-965, 2007.

0630F004

R.Chen, T.Takahashi, T.Kanda: Bariatric surgery for morbid obesity, N. Engl. J. Med., 357:1158-1160, 2007.

Presentations at Conference
International Conference (Presentations)
0630I001

T.Kanda, T.Takahashi, H.Sumino, S.Morimoto, T.Nakahashi, K.Iwai, M.Matsumoto: Candesartan Improves
Myocardial Damage in Obese Mice with Viral Myocarditis and Induces Cardiac Adiponectin., 4th Annual
Symposium of the American Heart Association Council on Basic Cardiovascular Sciences, (Keystone USA,'07.07)，American Heart Association, :13, 2007.

0630I002

T.Takahashi, K.Nomura, H.Honda, T.Nakahashi, T.Kanda, S.Morimoto: Seroprevalence of Human
Metapneumovirus in Elderly Inpatients in Japan, 45th Annual Meeting of IDSA, (SanDiego USA, '07.10)，Final
Program and Abstracts, :224-225, 2007.

0630I003

J.Moriya, J.Yamakawa, Y.Motoo, T.Takahashi, T.Kanda: Effect of Hochuekkito(Bu Zhong Yi Qi Tang)on Physical
Activity of Murine Model of Chronic Fatigue Syndrome., The14th International Congress of Oriental Medicine,(Taiwan, '07.12).

0630I004

J.Yamakawa, J.Moriya, Y.Motoo, T.Takahashi, F.Yoshizaki, T.Kanda: A Kampo Medicine, Boiogito(FangyiHuangqi-Tang), Inhibits Obesity in Ovariectomized Rats., The14th international Congress of Oriental Medicine,(Taiwan, '07.12).

－ 98 －

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

Assistant Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastic cancer

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer－ 99 －

0650

Department of Rehabilitation Medicine

Faculty
Title

Name

Professor

YAMAGUCHI Masao

Senior AssistantProfessor(Additional Post)

NAKATA Minori

Field of Specialization
Gait analysis using EMG power spectrum．Sway paths of the center ofgravity；post hip surgery of the patient with osteoarthritis of the hip．
Clinical pathway of the patient with femoral neck fractur.
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Presentations at Conference
International Conference (Synposium)
0650H001

T.Nakahashi, M.Atsumi, H.Murai, K.Nomura, K.Ishigami, E.Miyauchi, H.Tsuchiya, K.Iwai, M.Yamaguchi,
S.Morimoto: The effect of great earthquake on blood pressure, The 8ht china-japan joint hypertension symposium,(China, '07.11)，6th asian-pacific congress of hypertension 9th international syimposium on hypertension andrelated diseases abstract, 117, 2007.

－ 100 －

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Associate Professor

USUDA Katsuo

Research Associate

AIKAWA Hirokazu

Field of Specialization
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema.
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening.
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology,.
thoracic surgery, lung cancer, video assisted thoracoscopic surgery．

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy

Publications
Originals
0660B001

M.Matoba, H.Tonami, T.Kondou, H.Yokota, K.Higashi, H.Toga, T.Sakuma: Lung Carcinoma : diffusion-weighted
MR imaging-preliminary evaluation with apparent diffusion coefficient, Radiology., 243:570-577, 2007.

0660B002

Z.Wang, J.Xu, G.Ma, M.Sagawa, M.Shimazaki, Y.Ueda, T.Sakuma: Chronic pulmonary artery occlusion increases
alveolar fluid clearance in rats, J. Thorac. Cardiovasc. Surg., 134:1213-1219, 2007.
－ 101 －

Reviews
0660C001

T.Sakuma: Protective effects of endogenous catecholamine on alveolar fluid balance in acute pancreatitis andhypoxia in rats, J. O. D., 3:90-94, 2007.

0660C002

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, T.Sakuma: Virtual bronchoscopy. Its usefulness
and future, J. Kanazawa. Med. Univ., 32:218-221, 2007 (in Japanese) .

Case Reports
0660D001

M.Sagawa, Y.Ueda, F.Matsubara, H.Sakuma, Y.Yoshimitsu, H.Aikawa, K.Usuda, H.Minato, T.Sakuma:
Intrapulmonary solitary fibrous tumor diagnosed by immunohistochemical and genetic approaches: report of a case,
Surg Today, 37:423-425, 2007.

0660D004

T.Terauchi, M.Takenaka, Y.Asakura, M.Nakano, K.Sato, M.Sagawa, N.Kurose, T.Nojima: Pulmonary pleomorphic
carcinoma: two-case report, J. Jpn. Soc. Clin. Cytol., 46：227-231, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0660I001

Y.Machida, Z.Wang, M.Tanaka, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: Chronic pulmonary artery occlusion
increases alveolar fluid clearance rats, ATS2007 International Conference, (San Francisco, '07.05)，
Am.J.Respir.Crit.Care.Med, 175:A236, 2007.

0660I002

M.Tanaka, G.Ma, Y.Machida, H.Aikawa, K.Usuda, M.Sagawa, T.Sakuma: Bata-1 agonist, not beta-2 agonist,
increases alveolar fluid clearance in rats with renal failure, ATS2007 International Conference, (San Francicco,'07.05)，Am.J.Respi.Cri.Care Med., 175:A235, 2007.

－ 102 －

0670

Lifestyle-related Diseases Center

Faculty
Title

Name

Field of Specialization

Director(Additional Post)

MATSUI Shinobu

cardiac function, echocardiography, myocardial metabolism

Professor(Additional Post)

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterosecretiol

Professor(Additional Post)

TAMURA Nobuki

Physical physiology(The exercise testing and prescription fromthe physiological and biochemical research), Effects of theanemia on the physical activitiy, Exercise therapy for thelifestyle-related disease, Training for health Medical
Education.

Senior AssistantProfessor(Additional Post)

NAKANISHI Yumiko

Preventive medicine.

Assistant Professor

KUDOH AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology.

Assistant Professor

KITADA Munehiro

diabetes, hypertension.

Assistant Professor

KAMODA Sachikolifestyle-related disease, Preventive medicine.

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

Publications
Case Reports
0670D001

S.Kamoda, F.Enokido, I.Jibiki: Two cases of insomnia successfully treated with Yoku-kan-san, Journal of Japanese
Association of Oriental Psychosomatic Medicine., 22:62-66, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0670I001

S.Kamoda, H.Kawada, I.Jibiki: Four cases that combination therapy of donepezil and yoku-kan-san did success ofin patient with dementia, WPA Regional Meeting 2007 Seoul, (Korea, '07.04).

0670I002(H.Akazawa), C-H.Liao, Y.Kudo, S.Kudoh akazawa, I.Komuro: Essential roles of constitutive autophagy in quality
control of proteins in the hearts, XIX World Congress of the ISHR, (Italy, '07.06).

0670I003(H.Akazawa), C-H.Liao, Y.Kudo, K.Ito, N.Yasuda, Y.Qin, S.Kudoh akazawa, I.Komuro: Essential roles of Atg7 instarvation-induced and constitutive autophagy in the hearts, American Heart Association's Scientific Sessions
2007, (Florida, '07.11).

－ 103 －

0680

Medical Genetic Center

Faculty
Title

Name

Field of Specialization

Director(Additional Post)

KAKINUMA Hiroaki

child neurology, inborn errors of metabolism, congenital malformation,
medical genetics

ITO Masatsune

child endocrinology

SATO Hitoshi

clinical virology, child infectious disease

Assistant
Professor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
genetic variation, genetic mutation, genetic counseling, copy number variation

Outline of Research
genetic counseling, clinical genetics, congenital anomaly, child neurology, inborn
errors of metabolism, pediatric endocrinology.

－ 104 －

0690

Department of Endoscopy

Faculty
Title

Name

Associate Professor

ITOU Tohru

Assistant Professor

KAWAURA Ken

Field of Specialization
Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopicaltreatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Originals
0690B001

S.Saegusa, Y.Fei, T.Takahashi, H.Sumino, J.Moriya, K.Kawaura, J.Yamakawa, T.Itou, S.Morimoto, T.Nakahashi,
K.Iwai, M.Matsumoto, T.Kanda: Oral administration of candesartan improves the survival of mice with viral
myocarditis through modification of cardiac adiponectin expression, Cardiovasc Drugs Ther, 21:155-160, 2007.

0690B002

K.Kawaura, S.Fujii, Y.Murata, T.Hasebe, G.Ishii, T.Itou, Y.Sano, N.Saito, A.Ochiai: The lymphatic infiltration
identified by D2-40 monoclonal antibody predicts lymph node metastasis in submucosal invasive colorectal cancer.,
Pathobiology., 74-328-335, 2007.

Case Reports
0690D001

K.Miyazawa, T.Itoh, E.Kinoshita, T.Nojima, T.Takahashi, T.Kanda, K.Suzuki: Prostate cancer producing
carcinoembryonic antigen and carbohydrate antigen 19-9 without expression of prostate-specific antigen, J.
Kanazawa. Med. Univ., 32：29-31, 2007.

－ 105 －

－ 106 －School of Nursing

8010

Basic Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAWARA Tomoe

Feelings and QOL of sinior sitizuns living care-house run by amanicipal government or private sector.

Associate Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing.

Research Associate

FUKUTSUKA Takayo Quality of life of persons with sleep apnea syndrome.

Keywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

－ 107 －

8030

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

KITAOKA Kazuyo

Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability

Research Associate

NAGAI Makie

Occupational Mental Health

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has developed the Japanese research version of the Maslach
Burnout Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support
those people with mental disabiltiy.

Publications
Originals
8030B001(S.Yoshino), S.Sasahara, T.Maeno, K.Kitaoka-Higashiguchi, Y.Tomotsune, K.Taniguchi, E.Tomita, K.Usami,
T.Haoka, H.Nagamura, I.Matsuzaki: Relationship between mental health of Japanese residents and the quality of
medical service, Tairyoku Eiyo Menekigaku Zasshi., 17:3-11, 2007.

8030B002

K.Kitaoka-Higashiguchi, M.Sasaki, Y.Morikawa, H.Nakagawa: Applying the General Coping Questionnaire tonurses and the prospcet of the shortened version, Hokuriku Japanese Journal of Public Health., 33:56-59, 2007 (inJapanese) .

Reviews
8030C001

K.Kitaoka-Higashiguchi, W.Schaufeli: Burnout: an overview of 25 years of concept and research, Hokuriku
Japanese Journal of Public Health., 34:1-7, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8030I001

K.Kitaoka-Higashiguchi, T.Fuchisaki, A.Sakagami, R.Oketani, S.Seto, S.Hasegawa: Nursing job strain and burnout;prospective study, International Councils of Nurses Conference, (Yokohama, '07.05).

－ 108 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing.

Associate Professor

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring.

Assistant Professor

UCHIDA Maki

Cancer Nursing, Terminal Care.

Research Associate

KITAMURA Yoshiko

Cancer Nursing.

Research Associate

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease.

Keywords of Research
Nephrology Nursing, Transplant Nursing, Cronic Disease Nursing, Terminal Care, Cancer Nursing, Nursing Ethics

Outline of Research
Clinical Medical-Surgical Nursing.

－ 109 －

8050

Nursing of the Elderly

Faculty
Title

Name

Field of Specialization

Professor

AMATSU Eiko

Nursing of the Elderly.

Keywords of Research
Nursing of the Elderly

Outline of Research
Verification of Nursing Care about Daily living activities and their communication of the elderly with Dementia,also,theeffectiveness of the elderly Dementia prevention on the basis Local residents.
The Study of General Principle of Florence Nightingale connected with Nurse's recognition and expression in Nursing
phenomenon.

－ 110 －

8070

Maternity Nursing

Faculty
Title

Name

Field of Specialization

Professor

TSUKADA Tokie

Crinical nursing, Maternal and child health, Nursing education.

Associate Professor

SASANO Kyoko

Crinical nursing, Nursing education.

Research Associate

YORITSUNE Kaoru

Life development nursing.

Keywords of Research
Practice, Pregnancy, Midwife, Maternity Nursing, perinatal, after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8070B001

K.Sasano, H.Kakinuma, M.Hiramatsu, T.Nakamura, K.Takekawa: Current state and demand of pediatric emergency
services recognized by guardians in Ishikawa prefecture, Hokuriku Japanese Journal of Public Health., 34:29-34,
2007 (in Japanese) .

8070B002

M.Hiramatsu, T.Nakamura, H.Sato, K.Takekawa, K.Sasano, H.Kakinuma: The questionnaire survey of the current
situation in the pediatric emergency for the residents in Ishikawa prefecture, Japanese Society of Emergency
Pediatrics., 6：216-223, 2007 (in Japanese) .

－ 111 －

8080

Community Nursing

Faculty
Title

Name

Field of Specialization

Professor

FUKUMA Kazumi

Community Health Nursing

Assistant Professor

HAMAZAKI Yuko

public health nursing study of elder abuse

Research Associate

MATSUMOTO Yoshiko

Community Health nursing

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, successful aging, activity of cmmunity
organization

Outline of Research
We aim at the research of community nursing that contributes to sustain and improve quality of life and health of people inthe community. We have been studying about community nursing-care activity, community nursing education, Healthpromotion, successful aging and elder abuse

Publications
Originals
8080B001

Y.Hamazaki, K.Saeki, T.Kido: Studies of social activites and well-being of elderly in a regional core city (part1) :status of social activities of independent elderly, Hokuriku Japanese Journal of Public Health., 33:80-85, 2007
(in Japanese) .

8080B002

Y.Hamazaki, K.Saeki, K.Tsukasaki, T.Kido: Studies of social activites and well-being of elderly in a regional core
city (part 2) :factors on subjective well-being of people in their late old age, Hokuriku Japanese Journal of Public
Health., 33:86-91, 2007 (in Japanese) .

－ 112 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

MAEDA Shukohome care , home health care nurse.

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
Practice and restructuring of the infection control edcation program for home visiting nurses－ 113 －

8100

Human Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

OKADA Masato

Peripheral nerve surgery, Trauma

Professor

KAKINUMA Hiroaki

Pediatric neurology, Pediatric clinical genetics

Professor

KOHNO Hiroyuki

Experimental pathology,Tumor immunologg

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Associate Professor

HONDA Ryumon

Environment and health, Epidemiology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome

Outline of Research
T.Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M.Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
H.Kakinuma:Pediatric neurology, Pediatric clinical genetics.
H.Kohno: Experimental pathology, Tumor immunology.
Y.Morikawa: Cardiovascular epidemiology, occupational medicine.
M.Kojima: Study of Cataractogenesis mechanisms, Relation of the intraocular temperature during infrared exposure andenvironmental temperature.
R.Honda: Environment and health, Epidemiology

Books
8100A004

T.Tanaka, S.Miyamoto, Y.Yausi, H.Kohno, S.Sugie: Obesity: a risk for hepatocelullar carcinoma, Cancer: Disease
Progression and Chemoprevention(Takuji Tanaka), 57-74, Research Signpost, Kerala (India), 2007.

8100A005(M.Hosokawa), Y.Yausi, S.Suzuki, H.Kohno, T.Tanaka: Chemopreventive effects of conjugated linolenic acids oncolon cancer, Cancer: Disease Progression and Chemoprevention(Takuji Tanaka), 239-254, Research Signpost,
Kerala (India), 2007.

Publications
Originals
8100B001

M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki: Efficacy of α-lipoic acid against diabetic cataract inrat, Jpn. J. Ophthalmol., 51:10-13, 2007.

8100B002

J.Yoshida, T.Ishibashi, M.Nishio: G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, inhuman epidermoid carcinoma A431 cells, Biochem. Pharmacol., 73：943-953, 2007.

－ 114 －

8100B003(W.Teeyakasem), M.Nishijo, R.Honda, S.Satarug, W.Swaddiwudhipong, W.Ruangyuttikarn: Monitoring of cadmium
toxicity in a Thai population with high-level environmental exposure, Toxicol. Lett., 169:185-195, 2007.

8100B004(K.Wake), H.Hongo, S.Watanabe, M.Taki, Y.Kamimura, Y.Yamanaka, T.Uno, M.Kojima, I.Hata, K.Sasaki:
Development of a 2.45-GHz local exposure system for In Vivo study on ocular effects, IEEE Trans. Microw.
Theory Tech., 55:588-596, 2007.

8100B005

S.Yoneyama, K.Miura, S.Sasaki, K.Yoshita, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Dietaryintake of fatty acids and serum C-reactive protein in Japanese, J Epidemiol, 17:86-92, 2007.

8100B006

A.Nasermoaddeli, K.Miura, A.Matsumori, Y.Soyama, Y.Morikawa, A.Kitabatake, Y.Inaba, H.Nakagawa: Prognosis
and prognostic factors in patients with hypertrophic cardiomyopathy in Japan: results from a nationwide study,
Heart, 93:711-715, 2007.

8100B007(A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa: Temperature elevation in the eye of
anatomically based human head models for plane-wave exposures, Phys. Med. Biol., 52:6389-6399, 2007.

8100B008(Y.Suwazono), E.Kobayashi, M.Dochi, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa:
Combination of the C1429T polymorphism in the G-protein beta-3 subunit gene and the A1330V polymorphism in
the low-density lipoprotein receptor-related protein 5 gene is a risk factor for hypercholesterolaemia, Clin. Exp.
Med., 7:108-114, 2007.

8100B009

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, F.Beppu, M.Hosokawa, K.Miyashita, T.Tanaka: 9trans,11transconjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats,
Nutr. Cancer., 59:82-91, 2007.

8100B010

Y.Yasui, R.Suzuki, S.Miyamoto, T.Tsukamoto, S.Sugie, H.Kohno, T.Tanaka: A lipophilic statin, pitavastatin,
suppresses inflammation-associated mouse colon carcinogenesis, Int. J. Cancer, 121:2331-2339, 2007.

8100B011

T.Nakamura, J.Yamamura, H.Sato, H.Kakinuma, H.Takahashi: Vasculitis induced by immunization with Bacillus
Calmette-Guerin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease, FEMS
Immunol. Med. Microbiol., 49:391-397, 2007.

8100B012

K.Hayashi, R.Suzuki, S.Miyamoto, S.Yoshitani, H.Kohno, S.Sugie, S.Takashima, T.Tanaka: Citrus auraptene
suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice, Nutr. Cancer., 58:7584, 2007.

8100B013

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, K.Wakabayashi, T.Tanaka: Ursodeoxycholic acid versus sulfasalazine incolitis-related colon carcinogenesis in mice, Clin. Cancer Res., 13:2519-2525, 2007.

8100B014

H.Kohno, M.Takahashi, Y.Yasui, R. Suzuki, S.Miyamoto, Y.Kamanaka, M.Naka, T.Maruyama, K.Wakabayashi,
T.Tanaka: A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large
bowel carcinogenesis in male ApcMin/+ mice, Int. J. Cancer, 121:506-513, 2007.

8100B015

H.Kohno, Y.Totsuka, Y.Yasui, R.Suzuki, S.Sugie, K.Wakabayashi, T.Tanaka: Tumor-initiating potency of a novel
heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model, Int. J. Cancer, 121:1659-1664,
2007.

8100B016

Y.Morikawa, H.Nakagawa, K.Miura, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, K.Nogawa: Effect ofshift work on body mass index and metabolic parameters, Scand. J. Work Environ. Health, 33:45-50, 2007.

8100B017(S.Miyamoto), R.Suzuki, Y.Yasui, H. Kohno, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka: Lack of enhancing effectof lauric acid on the development of aberrant crypt foci in male ICR mice treated with azoxymethane and dextran
sodium sulfate, J. Toxicol. Pathol., 20:93-100, 2007.

8100B018(K.Fujikake), M.Miyao, R.Honda, M.Omori, Y.Matsuura, H.Takada: Evaluation of high qualiry LCDs displaying
moving pictures, on the basis of the form obtained from statokinesigrams, Forma, 22:199-206, 2007.

8100B019

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

－ 115 －

8100B020

K.Kitaoka-Higashiguchi, M.Sasaki, Y.Morikawa, H.Nakagawa: Applying the General Coping Questionnaire tonurses and the prospcet of the shortened version, Hokuriku Japanese Journal of Public Health., 33:56-59, 2007 (inJapanese) .

8100B021

Q.Jingtao, H.Sasaki, L.Zhongxin, Z.Jinsheng, W.Kaili, M.Kojima, Y.Sakamoto, R.Honda, Y.Kawakami,
Y.Yamashiro, Z.Jinsong, K.Sasaki, Japan-China Co-operative Study Group: Ｃｕｒｒｅｎｔ ｓｔａｔｕｓ ａｂｏｕｔ ｂｌｉｎｄｎｅｓｓ
ａｍｏｎｇ ｌｏｗ‐income farmers in Sanya district, hainan, China, Japanese journal of clinical ophthalmology Rinsho
ganka., 61:411-416, 2007 (in Japanese) .

8100B023

Y.Matsue, T.Nakamura, H.Sato, C.Akita, M.Hiramatsu, T.Kito, C.Kitaoka, J.Yamamura, T.Ikeda, T.Fujiki, M.Ito,
A.Kobayashi, T.Nakamura, H.Kakinuma, E.Koh, H.Takahashi: Clinial importance of basic life support in childhood
submersion, Japanese journal of pediatrics., 60:1195-1199, 2007 (in Japanese) .

8100B026

K.Sasano, H.Kakinuma, M.Hiramatsu, T.Nakamura, K.Takekawa: Current state and demand of pediatric emergency
services recognized by guardians in Ishikawa prefecture, Hokuriku Japanese Journal of Public Health., 34:29-34,
2007 (in Japanese) .

8100B027

M.Hiramatsu, T.Nakamura, H.Sato, K.Takekawa, K.Sasano, H.Kakinuma: The questionnaire survey of the current
situation in the pediatric emergency for the residents in Ishikawa prefecture, Japanese Society of Emergency
Pediatrics., 6：216-223, 2007 (in Japanese) .

Reviews
8100C001(B.Narayan), M.Hosokawa, Y.Yasui, R.Suzuki, H.Kohno, T.Tanaka, K.Miyashita: Chemopreventive effects ofconjugated linolenic acids (CLN) occurring in plant seed oils, Current nutrition & food science., 3:309-318, 2007.

Case Reports
8100D001

H.Kakinuma, A.Hori, M.Ito, T.Nakamura, H.Takahashi: An inherited disorder characterized by repeated episodesof bilateral ballism: a case report, Mov. Disord., 22:2110-2131, 2007.

Short Communications
8100E001

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, Organohalogen Compounds., 69-2031-2034,
2007.

Others
8100F001

Y.Noborisaka, R.Honda, M.Ishizaki, M.Nakata, Y.Yamada: Alcohol and cigarette consumption, renal function andblood pressure in middle-aged healthy men, J Hum Hypertens, 21:966-968, 2007.

8100F007

M.Kojima: Ultraviolet exposure as a risk factor in cataract formation, J & J, 1-2, 2007 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
8100H001

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, 27th International symposium on halogenatedpersistent organic pollutants, (Tokyo, '07.08).

8100H002(K.Nambunmee), T.Pham-The, R.Honda, M.Nishijo, K.Miura, H.Nakagawa, W.Rungyuttikarn: Association of renal
tubular injury and bone resoption induced by cadmium expusure of inhabitants living in polluted area, Maesot
district, Tak province, Thailand, 6th Annual congress of Asia Pacific association of medical toxicology, (Bangkok,'07.12).

－ 116 －

8100H003(T.Pham-The), K.Nambunmee, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow up study about
effects of cadmium (Cd) on renal functions among Japanese population living in a non-polluted area, 6th Annual
congress of Asia Pacific association of medical toxicology, (Bangkok, '07.12).

International Conference (Presentations)
8100I001

K.Miyazawa, S.Miyamoto, R.Suzuki, Y.Yasui, R.Ikeda, H.Kohno, M.Yano, T.Tanaka, K.Hata, K.Suzuki: Dietarybeta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis inmale ICR mice, The 22nd Annual EAU Congress, (Berlin, '07.03).

8100I002

Y.Yasui, H.Kohno, R.Suzuki, S.Sugie, N.Niho, M.Takahashi, K.Wakabayashi, T.Tanaka: Dextran sodium sulfate
strongly promotes colon carcinogenesis in ApcMin/+ mice, The 2nd Biennial Svientific Meeting of International Society for
Gastrointestinal Hereditary Tumours, (Yokohama, '07.03).

8100I003

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, T.Tanaka: A lipophilic statin, pitavastatin inhibits inflammationassociated mouse colon carcinogeness., 98th Annual Meeting of American Association for Cancer Research, (LosAngeles, '07.04).

8100I004(S.Miyamoto), K.Hayashi, R.Suzuki, H.Kohno, S.Sugie, S.Takashima, A.Murakami, H.Ohigashi, T.Tanaka: Citrus
auraptene suppreses azoxymethane-induced colonic preneoplasia in db/db mice, 98th Annual Meeting of American
Association for Cancer Research, (Los Angeles, '07.04).

8100I005

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, T.Tanaka: Ursodeoxycholic acid inhibits colitis-related colon
carcinogenesis in mice: A comparative study regarding the effect of sulphasalazine, 98th Annual Meeting ofAmerican Association for Cancer Research, (Los Angeles, '07.04).

8100I006

K.Nagai, H.Sasaki, R.Honda, M.Kojima, Y.Sakamoto, J.Qu, K.Sasaki: Prevalence of cataract in eyes with posterior
vitreous detachment, Association for Research in Vision and Ophthalmology, (Florida, '07.05).

8100I007

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.Liu, J.Zhang, K.Sasaki: True exfoliation in chinese
population in a tropical area -The Sanya Eye Study-, Association for Research in vision and Ophthalmology,(Florida, '07.05).

8100I008

M.Kojima, Y.Yamashiro, M.Hanazaw, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Investigation of frequency
specificity of ocular effects through quasi-millimeter and millimeter wave exposure, Association for Research in
Vision and Ophthalmology, (Florida, '07.05).

8100I009

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: The relationshipof axial length and three main types of cataract in the population of a tropical area of China, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

8100I010(H.Wakatsuchi), M.Hanazawa, T.Sakai, S.Watanabe, M.Kojima, Y.Yamashiro, K.Sasaki, O.Hashimoto: Complex
permittivities measurements of ocular tissues in quasi-millimeter and millinmeter wave bands, Bioelectromagnetics,(Kanazawa, '07.06).

8100I011

M.Kojima, M.Hanazawa, Y.Yamashiro, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Possibility of frequency specificityof ocular effects by quasi-millimeter and, Bioelectromagnetics, (Kanazawa, '07.07).

8100I012

Y.Yasui, R.Suzuki, H.Kohno, S.Miyamoto, S.Sugie, T.Tanaka: A lipophilic statin, pitavastatin inhibits colitisrelated colon carcinogenesis in mice, The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research, (Gifu,'07.08).

8100I013

H.Kohno, R.Suzuki, Y.Yasui, S.Miyamoto, S.Sugie, T.Tanaka: Ursodeoxycholic acid inhibits colitis-related colon
carcinogenesis in mice, The 8th Japan-Korea Joint Symposium on Cancer and Ageing Research, (Gifu, '07.08).

8100I014

T. Ishibashi, N. Nishizawa, M. Nomura, J. Yoshida, M. Nishio: Arterio-venous difference of nitrite kinetics inanesthetized rabbits, Second International Role of Nitrite in Physiology, Pathophysiology, and Therapeutics
Meeting, (Bethesda Meryland, USA, '07.09).

8100I015

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki: Difference of ocular injury by millimetr wave exposure with different
frequency, European associatio for Vision and Eye Research, (Slovenia, '07.10).

－ 117 －

8100I016(M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Kamataki, T.Nohmi: Chemopreventive
effects of nobiletin, a citrus constituent, against the genotoxicity of NNK, a tobacco-specific nitrosamine, in thelung of gpt delta transgenic mice, 9th International Conference on Mechanisms of Antimutagenesis andAnticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

8100I017

K.Nagai, H.Sasaki, R.Honda, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: Change of light scattering intensity ineyes with posterior vitreous detachment, Monzen eye study, US-Japan Cooperative Cataract Research Group
Meeting, (Hawaii, '07.12).

8100I018

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD (eyedrops) on UV-B-induced cataract in rats, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'07.12).

8100I019

M.Kojima, Y.Yamashiro, Y.Sakamoto, Y.Kawakami, H.Sasaki, K.Sasaki: Difference of cataract development bydifferent frequency in millimeter wave, US-Japan Cooperative cataract Research Group Meeting, (, '07.12).

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Medical Research Institute

0740

Division of Human Genetics (Biochemistry)

Faculty
Title

Name

Professor

KUHARA Tomiko

Associate Professor

SHINKA Toshihiro

Senior Assistant Professor

INOUE Yoshito

Researcher

OHSE Morimasa

Field of Specialization
Human metabolome analysis for diagnosis of metabolic disorders andpersonalized medicine
Chemical diagnosis of metabolic disorders by mass spectrometry(Tyrosinosis, Metabolic disorders of fatty acid beta oxidation,
Acylcarnitine analysis, Sulfated bile acids analysis)
Chemical diagnosis and follow up study for metabolic disorders (ureacycle disorders, prenatal diagnosis of organic acidemias, Canavan
disease, optical isomer analysis)
Development of data handling method from mass measurement value
to evaluation value in diagnosis software

Keywords of Researchhuman genetics, metabolome, pharmacogenomics, nutrinogenomics, metabolomics, mass spectrometry, inborn errors of
metabolism, molecular diagnosis, organic acidemia, gas chromatography-mass spectrometry, chemical diagnosis, pilot studyof neonatal screening, prenatal diagnosis, personalized medicine, stable isotope dilution, tandem mass spectrometry,electrosplay ionization mass spectrometry, 5-fluorouracil toxicity, metabolic profiling, aminoacidemia/aminoaciduria, fatty
acid β-oxidation, carnitine, acylcarnitine

Publications
Originals
0740B001

T.Shinka, Y.Inoue, M.Ohse, T.Kuhara: Simple and quantitative analysis of urinary sulfated tauro- andglycodihydroxycholic acids in infant with cholestasis by electrospray ionization mass spectrometry, J. Chromatogr.
B Analyt. Technol. Biomed. Life Sci., 855:104-108, 2007.

0740B002

Y.Inoue, T.Shinka, M.Ohse, M.Kohno, K.Konuma, H.Ikawa, T.Kuhara: Changes in urinary level and configuration
ratio of D-lactic acid in patients with short bowel syndrome, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.,
855:109-114, 2007.

Reviews
0740C001

T.Kuhara: Noninvasive human metabolome analysis for differential diagnosis of inborn errors of metabolism, J.
Chromatogr. B Analyt. Technol. Biomed. Life Sci., 855:42-50, 2007.

Presentations at Conference
International Conference (Synposium)
0740H001

T.Shinka: The role of GC/MS in diagnosis of inborn errors of metabolism, Second Genetic Metabolic Symposium,(Bangkok, '07.11)，Joint Symposia "Medical Genetics Update 2007" and "Second Genetic Metabolic Symposium",2007.

－ 119 －

0750

Division of Human Genetics (Clinical Medicine)

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KAKINUMA HiroakiChild neurology, inborn errors of metabolism, clinical genetics

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine

Research Associate

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Keywords of Research
genetic counseling, genetic service, prenatal diagnosis, congenital abnormality

Publications
Originals
0750B001(A.Sekizawa), Y.Purwosunu, A..Farina, T.Okai, H.Takabayashi, M.Kita, H.Yura, M.Kitagawa: Development of
noninvasive fetal DNA diagnosis from nucleated erythrocytes circulating in maternal blood, Prenat. Diagn., 27:846848, 2007.

0750B002

T.Nakamura, J.Yamamura, H.Sato, H.Kakinuma, H.Takahashi: Vasculitis induced by immunization with Bacillus
Calmette-Guerin followed by atypical mycobacterium antigen: a new mouse model for Kawasaki disease, FEMS
Immunol. Med. Microbiol., 49:391-397, 2007.

0750B003

Y.Matsue, T.Nakamura, H.Sato, C.Akita, M.Hiramatsu, T.Kito, C.Kitaoka, J.Yamamura, T.Ikeda, T.Fujiki, M.Ito,
A.Kobayashi, T.Nakamura, H.Kakinuma, E.Koh, H.Takahashi: Clinial importance of basic life support in childhood
submersion, Japanese journal of pediatrics., 60:1195-1199, 2007 (in Japanese) .

0750B005

K.Sasano, H.Kakinuma, M.Hiramatsu, T.Nakamura, K.Takekawa: Current state and demand of pediatric emergency
services recognized by guardians in Ishikawa prefecture, Hokuriku Japanese Journal of Public Health., 34:29-34,
2007 (in Japanese) .

0750B006

M.Hiramatsu, T.Nakamura, H.Sato, K.Takekawa, K.Sasano, H.Kakinuma: The questionnaire survey of the current
situation in the pediatric emergency for the residents in Ishikawa prefecture, Japanese Society of Emergency
Pediatrics., 6：216-223, 2007 (in Japanese) .

Reviews
0750C001(W.Peng), H.Takabayashi, K.Ikawa: Whole genome amplification from single cells in preimplantation genetic
diagnosis and prenatal diagnosis, Eur. J. Obstet. Gynecol. Reprod. Biol., 131:13-20, 2007.

Case Reports
0750D001

K.Sato, Y.Ueda, J.Sugaya, M.Ozaki, M.Hisaoka, S.Katsuda: Extrauterine endometrial stromal sarcoma withJAZF1/JJAZ1 fusion confirmed by RT-PCR and interphase FISH presenting as an inguinal tumor, Virchows Arch.,
450:349-353, 2007.

0750D002

H.Kakinuma, A.Hori, M.Ito, T.Nakamura, H.Takahashi: An inherited disorder characterized by repeated episodesof bilateral ballism: a case report, Mov. Disord., 22:2110-2131, 2007.

－ 120 －

0770

Division of Core Facility (Radioisotope Center)

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Research Associate

YAMASHITA Masatoshi

Radiation safety management.

Keywords of Research
RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis,
Energy-filtering electron microscopy, Element mapping, Ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, centrosome, tumor growth angiogenesis, micro RNA

Outline of Research
Quality control of genetic information

Publications
Originals
0770B001

T.Shimasaki, Y.Ishigaki, T.Minato, Y.Motoo: Apoptosis-related gene expression profile is changed by gemcitabine
in pancreatic cancer cell line(PANC-1), The Journal of Japan Pancreas Society., 22:14-20, 2007 (in Japanese) .

Others
0770F001(Kiba T), Y.Kintaka, E.Nakada, Y.Suzuki, S.Inoue, Y.Ishigaki: High-quality RNA extraction from rat pancreas for
microarray analysis, Pancreas, 35:98-100, 2007.

Presentations at Conference
International Conference (Presentations)
0770I001

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).

0770I002

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

－ 121 －

0780

Division of Core Facility (Experimental Animal Center)

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MATSUI Shinobu

cardiac function, echocardiography,myocardial metabolism.

Senior Assistant Professor

SO Shihei zong zhi pingcell cycle control and immunopathology.

Keywords of Researchcardiac function, echocardiography, myocarial metabolism, cell cycle control and immunopathology

Outline of Research
1. cardiac function, echocardiography, myocarial metabolism.
2. cell cycle control and immunopathology.

Publications
Originals
0780B001

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

－ 122 －

0790

Division of Core Facility (Morphological Equipment Center)

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

KURIHARA Takayuki Mechanism of Chromosomal Instability

Keywords of ResearchMechanism of Chromosomal Instability.

Outline of ResearchMechanism of Chromosomal Instability.

－ 123 －

0800

Division of Core Facility (High-Tech Research Center)

Faculty
Title

Name

Field of Specialization

Associate
Professor(Additional Post)NISHIJO Muneko

Epidemiology of health effects of environmental cadmium exposure,and dioxins., Toxicology of environmental pollutants.

Researcher

OKUWA Takako

neurovirology

Researcher

KIM Mihye

Cancer chemoprevention by natural products.

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
0800B001(W.Teeyakasem), M.Nishijo, R.Honda, S.Satarug, W.Swaddiwudhipong, W.Ruangyuttikarn: Monitoring of cadmium
toxicity in a Thai population with high-level environmental exposure, Toxicol. Lett., 169:185-195, 2007.

0800B002

M.Nishijo, J.Kuriwaki, E.Hori, K.Tawara, H.Nakagawa, H.Nishijo: Effects of materinal exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin on fetal brain growth and motor and behiavioral development in offspring rats,
Toxicol. Lett., 173:41-47, 2007.

0800B003

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

Short Communications
0800E001(T.Kido), S.Maruzeni, H.Suzuki, Y.Odamae, M.Muranaka, R.Naganuma, K.Tawara, M.Nishijo, H.Nakagawa,
TM.Hung, LTH.Thom, PT.Dung, DD.Nhu, H.Oka, K.Noguchi: Five years studies on the long term effects ofwaragent orange/dioxin on human health in Vietnam, Organohalogen Compounds., 69:572-575, 2007.

0800E002(M.Muranaka), T.Kido, Y.Odamae, H.Suzuki, R.Naganuma, H.Nakagawa, M.Nishijo, K.Tawara, TM.Hung,
LTH.Thom, PT.Dung, DD.Nhu: An epidemiological study on health effects by dioxin in Vietnam; comparison ofvisual acuity of junior high school students between herbicide sprayed and non-sprayed areas, Organohalogen
Compounds., 69:2035-2038, 2007.

0800E003

K.Tawara, M.Nishijo, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, TM.Hung, LTH.Thom, PT.Dung, DD.Nhu:
Association of having birth defect chiledren with serum dioxin levels in Vietnam, Organohalogen Compounds.,
69:568-571, 2007.

0800E004

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pam, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)disturbed development of taste preference in rat offspring,
Organohalogen Compounds., 69:1809-1812, 2007.
－ 124 －

0800E005

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, Organohalogen Compounds., 69-2031-2034,
2007.

Presentations at Conference
International Conference (Synposium)
0800H001

K.Tawara, M.Nishijo, R.Honda, H.Nakagawa, T.Seto, T.Kido: Relationship between food preference in women and
PCDDs/DFs levels in breast milk in the northern district of Japan, 27th International symposium on halogenatedpersistent organic pollutants, (Tokyo, '07.08).

0800H002(K.Nambunmee), T.Pham-The, R.Honda, M.Nishijo, K.Miura, H.Nakagawa, W.Rungyuttikarn: Association of renal
tubular injury and bone resoption induced by cadmium expusure of inhabitants living in polluted area, Maesot
district, Tak province, Thailand, 6th Annual congress of Asia Pacific association of medical toxicology, (Bangkok,'07.12).

0800H003(T.Pham-The), K.Nambunmee, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow up study about
effects of cadmium (Cd) on renal functions among Japanese population living in a non-polluted area, 6th Annual
congress of Asia Pacific association of medical toxicology, (Bangkok, '07.12).

International Conference (Presentations)
0800I001

M.Nishijo, J.Kuriwaki, A.Hashimoto, K.Fukunaga, H.Nakagawa, T.Pham, E.Hori, K.Torii, H.Nishijo: Prenatal
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disturbed development of taste preference in rat off-springs, 27th
International symposium on halogenated persistent organic pollutants, (Tokyo, '07.08).

0800I002

Pham-The T, Nambunmee K, R.Honda, M.Nishijo, K.Miura, H.Nakagawa: Eight-year follow-up study (from 1998
to 2006) about effects of cadmium on renal functions among Japanese population living in a non-polluted area., 6th
Annual Congress of Asia-Pacific Association of Medical Toxicology, (Bangkok, '07.12).

0800I003

Y.Yasui, M.Kim, S.Miyamoto, R.Ishigamori-Suzuki, S.Sugie, T.Tanaka: The inhibitory effect of pitavastatin oncolitis-related colon carcinogenesis in mice, 9th International Conference on Mechanisms of Antimutagenesis andAnticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

0800I004

T.Tanaka, Y.Yasui, M.Kim, S.Miyamoto, F.Epifano, M.Curini, S.Genovese, R.Ishigamori-Suzuki: A novel prodrugof ferulic acid suppresses AOM/DSS-induced mouse colon carcinogenesis, 9th International Conference on
Mechanisms of Antimutagenesis and Anticarcinogenesis (ICMAA-2007), (Jeju Island (Korea), '07.12).

0800I005

M.Kim, Y.Yasui, S.Miyamoto, S.Sugie, A.Murakami, R.Ishigamori-Suzuki, T.Tanaka: Dietary pitavastatin inhibits
4-nitroquinoline-1-oxide-induced carcinogenesis in the upper-digestive organs of rasH2 mice, 9th International
Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis (ICMAA-2007), (Jeju Island (Korea),'07.12).

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0900

Division of Cell Medicine

Faculty
Title

Name

Field of Specialization

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle,transformation

Assistant Professor

MIYAGOSHI Minoru

Cell biology

Keywords of Research
polyploid cells, polyploidization, Meth-A cells, V79 cells, triploid cells, tetraploid cells, octaploid cells, H-1(ES)cells

Outline of Research
Study of polyploid cells

Publications
Originals
0900B001

K. Fujikawa-Yamamoto, M. Miyagoshi, H. Yamagishi: Establishment of a tetraploid cell line from mouse H-1 (ES)cells highly polyploidized with demecolcine, Cell Prolif., 40:327-337, 2007.

0900B002

M. Miyagoshi, K. Fujikawa-Yamamoto, Y. Yamagishi: The establishment of tetraploid V79 cells using demecolcine,J. Kanazawa. Med. Univ., 32:170-175, 2007.

0900B003

K. Fujikawa-Yamamoto, M. Miyagoshi, Y. Yamagishi: Polyploidization of 2nH-1 (ES) cells by K-252a andstaurosporine, Hum. Cell., 20:91-99, 2007.

Reviews
0900C001

K.Fujikawa: A hypothesis for the fractal structure of mammalian genome Ⅰ -The construction of a hypothesis-, J.
Kanazawa. Med. Univ., 32:89-95, 2007 (in Japanese) .

0900C002

K.Fujikawa: A hypothesis for the fractal structure of mammalian genome Ⅱ -The genome structure of polyploidcells-, J. Kanazawa. Med. Univ., 32:96-101, 2007 (in Japanese) .

－ 126 －

0910

Division of Advanced Medicine

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Shinobu

Clinical cardiology

Professor

TOMOSUGI Naohisa

Clinical Nephrology

Associate Professor

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Keywords of Researchheart failure, cardiomyopathy, nerohumoral factor, immunity, autoantibody, spermatogenesis, cell cycle, epigenetics,
endocrine disruptors, meiosis

Outline of Research
1.Myocardial injury due to autoimmunity against G-protein-coupled receptor. Growing evidence suggested that G-proteincoupled receptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated
cardiomyopathy. Our study showed that specific removal of anti-G-protein coupled receptor autoantibodies improved
cardiac structure and function in experimental autoimmune cardiomyopathy.
2.Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.
However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has beendeveloped. Here, we employed surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOFMS) to analyze the expression of serum hepcidin in hemodialysis patients. Hepcidin-25 was found to accumulate in theserum of hemodialysis patients; this could contribute to the pathogenesis of renal anemia by decreasing the available ironfor hematopoiesis.
3.Histone modifications in meiotic prophase of spermatogenesis.

Publications
Originals
0910B001

H.Yokota, J.Guo, M.Matoba, K.Higashi, H.Tonami, Y.Nagao: Lactate, choline, and creatine levels measured byvitro 1H-MRS as prognostic parameters in patients with non-small-ceｌｌ lung cancer, J. Magn. Reson. Imaging.,
25:992-999, 2007.

0910B002

M.Nakashima, K.Miura, S.Matsui, N.Tamura, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Screening programusing exercise electrocardiogram for new students in a medical school: findings during past 20 years, Hokuriku
Japanese Journal of Public Health., 33:76-79, 2007 (in Japanese) .

Reviews
0910C003

N.Tomosugi: Iron overload in renal anemia, The Japanese journal of clinical dialysis., 23:1555-1562, 2007 (inJapanese) .

Others
0910F001(H.Kawabata), N.Tomosugi, J.Kanda, Y.Tanaka, K.Yoshizaki, T.Uchiyama: Anti-interleukin 6 receptor antibody
tocilizumab reduces the level of serum hepcidin in patients with multicentric Castleman's disease, Haematologica.,
92:857-858, 2007.

－ 127 －

Presentations at Conference
International Conference (Presentations)
0910I001

K.Kitagawa, N.Tomosugi, H.Tuchida, H.Sasaki: Automated identification and quantification of tear proteins from
Sjogern's syndrome by LC/MS on a hybrid linear ion trap mass spectrometer, 5th international Conference on the
Tear Film & Ocular Surface : Basic Science and Cliical Relevance, (Italy, '07.08).

0910I002

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).

0910I003

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

－ 128 －

0920

Division of Molecular Oncology and Virology

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology,Gastroenterology,Cancer Cell Biology

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Assistant Professor

MURAKAMI Manabu

Molecular analysis and development of antiviral drugs: Mechanism ofantiviral action of RNAi

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, hepatitis C virus, flavivirus, Japanese encephalitis
virus, virus replication, RhoGDI, Rho family, Eomes, epithelial/mesenchymal, nonstructural protein NS3, RNA synthesis,
transfection, persistent infection, RNAi

Outline of Research
Molecular analyses of virus replication, carcinogenesis and metastasis

Publications
Originals
0920B001

L.Dong, Y.Masaki, T.Takegami, T.Kawanami, K.Itoh, Z.Jin, C.Huang, X.Tong, T.Fukushima, M.Tanaka, T.Sawaki,
T.Sakai, S.Sugai, T.Okazaki, Y.Hirose, H.Umehara: Cloning and expression of two human recombinant monoclonal
Fab fragments specific for EBV viral capsid antigen, Int. Immunol., 19:331-336, 2007.

0920B002(J.Pei-hong), Y.Motoo: Expression of interleukin-22 in human melanoma cell line.(in Chinese), J. Clin.
Dermatology., 36:346-347, 2007.

0920B003(W.Mai), K.Miyashita, A.Shakoori, B.Zhang, Z.Wei Yu, Y.Takahashi, Y.Motoo, K.Kawakami, T.Minamoto:Detection of active fraction of glycogen synthase kinase 3β in cancer cells by nonradioisotopic in vitro kinase
assay, Oncology, 71:297-305, 2007.

0920B004(A.Ujike-Asai), A.Okada, Y.Du, M.Maruyama, X.Yuan, F.Ishikawa, Y.Motoo, K.Isobe, H.Nakajima: Large defectsof type l allergic response in telomerase reverse transcriptase knockout mice, J. Leukoc. Biol., 82:429-435, 2007.

0920B005

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A kampo medicine, boi-ogi-to,
inhibits obesity in ovariectomized rats, eCAM, 1-9, 2007.

0920B006

L.Dong, Y.Masaki, T.Takegami, Z.Jin, C.Huang, T.Fukushima, T.Sawaki, T.Kawanami, T.Saeki, K.Kitagawa,S.Sugai, T.Okazaki, Y.Hirose, H.Umehara: Clonality analysis of lymphoproliferative disorders in patients with
Sjögren's syndrome, Clin. Exp. Immunol., 150:279-284, 2007.

0920B007(M.Gironella), M.Seux, M-J.Xie, C.Cano, R.Tomasini, J.Gommeaux, S.Garcia, J.Nowak, ML.Yeung, K-T.Jeang,
A.Chaix, L.Fazli, Y.Motoo, Q.Wang, P.Rocchi, A.Russo, M.Gleave, J-C.Dagorn, JL.Iovanna, A.Carrier, MJ.Pébusque, NJ.Dusetti: Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its
restoration inhibits pancreatic tumor development., Proc. Natl. Acad. Sci. U.S.A., 104:16170-16175, 2007.

0920B008(S-B.Su), M-J.Xie, N.Sawabu, Y.Motoo: Suppressive effect of herbal medicine saikokeishito on acinar cell
apoptosis in rat spontaneous chronic pancreatitis, Pancreatology., 7:28-36, 2007.
－ 129 －

0920B009(D.Closa), Y.Motoo, JL.Iovanna: Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.,
World J. Gastroenterol., 13:170-174, 2007.

0920B010

T.Shimasaki, Y.Ishigaki, T.Minato, Y.Motoo: Apoptosis-related gene expression profile is changed by gemcitabine
in pancreatic cancer cell line(PANC-1), The Journal of Japan Pancreas Society., 22:14-20, 2007 (in Japanese) .

Case Reports
0920D001

Y.Takahashi, T.Kiba, K.Yamaguchi, Y.Saitou, K.Nishio, M.Iguchi, Y.Motoo: A case undergoing repeatedanaphylactic shok after systemic administration of vinorelbine, Cancer & chemotherapy., 34:2321-2323, 2007 (inJapanese) .

Short Communications
0920E001

T.Ota, M.Maeda, M.Murakami, T.Takegami, S.Suto, M.Tatsuka: Activation of Rac1 by Rho-guanine nucleotide
dissociation inhibitor-β with defective isoprenyl-binding pocket, Cell Biol. Int., 31:92-96, 2007.

Presentations at Conference
International Conference (Synposium)
0920H001

Y.Motoo, T.Shimasaki, T.Minamoto: Gemcitabine changes the gene expression of human pancreatic cancer cells :search for new therapeutic molecular targeting, NATO Advanced Research Workshop, (Tashkent,Uzbekistan,'07.09).

0920H002

Y.Motoo, I.Arai, I.Hyodo, K.Tsutani: Introduction of GRADE Profiler （GRADEpro）., Meeting on Development of
Evidence-based Clinical Practice Guidelines in Traditional Medicines 2007 supported by WHO, (Hong Kong,'07.12).

International Conference (Presentations)
0920I001(A.Kanda), S.Sakita-Suto, F.Suzuki, T.Ota, M.Inoue, O.Niwa, M.Tatsuka: Study on the damage-response signaltransduction generated in egg fertilized by sperm of ionizaing irradiated male parent., Hiroshima University 21stCentury COE Program ― Radiation Casualty Medical Research Center ― The 4th International Symposium,(Hiroshima, '07.02).

0920I002

T.Shimasaki, Y.Ishigaki, X.Zhao, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against pancreas cancer resulting in altered gene expression profiles,
The Second Meeting of Asian-Oceanic Pancreatic Association(AOPA), (Kobe, '07.10).

0920I003

T.Shimasaki, Y.Ishigaki, X.Zhao X, N.Tomosugi, T.Tanaka, W.Mai, K.Kawakami, T.Minamoto, Y.Motoo: Combined
effect of gemcitabine and GSK3βinhibitor against human pancreas cancer: GSK3βas a new therapeutic moleculartarget, 38th Annual Meeting of the American Pancreatic Association, (Chicago, '07.11).

0920I004

J.Moriya, J.Yamakawa, Y.Motoo, T.Takahashi, T.Kanda: Effect of Hochuekkito(Bu Zhong Yi Qi Tang)on Physical
Activity of Murine Model of Chronic Fatigue Syndrome., The14th International Congress of Oriental Medicine,(Taiwan, '07.12).

0920I005

J.Yamakawa, J.Moriya, Y.Motoo, T.Takahashi, F.Yoshizaki, T.Kanda: A Kampo Medicine, Boiogito(FangyiHuangqi-Tang), Inhibits Obesity in Ovariectomized Rats., The14th international Congress of Oriental Medicine,(Taiwan, '07.12).

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0930

Division of Dermatomycology (Novartis Pharma)

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology，Dermatomycosis

Senior AssistantProfessor(Additional Post)

KAWASAKI Masako

Medical mycology

Researcher

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans.

Publications
Originals
0930B001

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, J.S.Choi: Molecular epidemiology of Trichophyton
tonsurans isolated in Japan using RFLP analysis of non-transcribed spacer regions of ribosomal RNA genes, Jpn. J.
Infect. Dis., 60：188-192, 2007.

0930B002

M.Yanagihara, K.Takeda, H.Tanabe, S.Abe, H.Ishizaki: Follicular keratosis of the chin treated with 1.24Rdihydroxyvitamin D3 ointment, Pediatr. Dermatol., 24：412-414, 2007.

Case Reports
0930D001(H.Fujii), M.Tanioka, M.Yonezawa, A.Arakawa, Y.Matsumura, S.Kore-eda, Y.Miyachi, S.Tanaka, Herpes zoste: A
case of atypical sporotrichosis with multifocal cutaneous ulcers, Clin. Exp. Dermatol., 33：135-138, 2007.

0930D005(S.Okada), T.Masu, T.Tsunoda, M.Kawasaki, T.Mochizuki, R.Okuyama, S.Aiba: A case of Phaeohyphomycosis
infected with Exophiala jeanselmei, Nishinihon j. dermatol., 69：162-164, 2007 (in Japanese) .

0930D009(S.Fujita), T.Mochizuki: A case of black dot ringworm on the right forearm caused by Trichophyton tonsurans, The
Japanese Society for Medical Mycology., 48：91-95, 2007 (in Japanese) .

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Presentations at Conference
International Conference (Key Note Lecture)
0930G001

M.Kawasaki: Molecular biology and black fungi around the world, 21st World Congress of Dermatology, (Buenos
Aires., '07.10).

International Conference (Synposium)
0930H001

M.Kawasaki, H.Ishizaki: Global molecular biology and Sporothrix schenckii, 21st World Congress of Dermatology,(Buenos Aires., '07.10).

International Conference (Presentations)
0930I001

M.Terada, J.Fujita, S.Watanabe, H.Tanabe, M.Kawasaki, T.Mochizuki: A case of hyalohyphomycotic cyst caused
by Fusarium solani, 21st World Congress of Dermatology, (Buenos Aires., '07.10).

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0970

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis.

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

KAWAKAMI Yutaka

cataract, thyroid ocular.

YAMASHIRO Yoko

ｃataract，electromagnetic wave induced ocular tissue changes，
epidemiology

Associate
Professor(Additional Post)
Assistant
Professor(Additional Post)
Researcher

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
0970B001

M.Kojima, L.Sun, I.Hata, Y.Sakamoto, H.Sasaki, K.Sasaki: Efficacy of α-lipoic acid against diabetic cataract inrat, Jpn. J. Ophthalmol., 51:10-13, 2007.

0970B002(K.Wake), H.Hongo, S.Watanabe, M.Taki, Y.Kamimura, Y.Yamanaka, T.Uno, M.Kojima, I.Hata, K.Sasaki:
Development of a 2.45-GHz local exposure system for In Vivo study on ocular effects, IEEE Trans. Microw.
Theory Tech., 55:588-596, 2007.

0970B003(T.Olsen), A.Arnarsson, H.Sasaki, K.Sasaki, F.Jonasson: On the ocular refractive components : the Reykjavik eye
study, Acta Ophthalmol. Scand., 85:361-366, 2007.

0970B004(A.Arnarsson), KF.Damji, T.Sverrisson, H.Sasaki, F.Jonasson: Pseudoexfoliation in the Reykjavik eye study :prevalence and related ophthalmological variables, Acta Ophthalmol. Scand., 85:822-827, 2007.

0970B005

I.Shima, S.Katsuda, Y.Ueda, N.Takahashi, H.Sasaki: Expression of matrix metalloproteinases in wound healing after
glaucoma filtration surｇery in rabbits, Ophthalmic Res., 39:315-324, 2007.

0970B006(A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa: Temperature elevation in the eye of
anatomically based human head models for plane-wave exposures, Phys. Med. Biol., 52:6389-6399, 2007.
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0970B008

Q.Jingtao, H.Sasaki, L.Zhongxin, Z.Jinsheng, W.Kaili, M.Kojima, Y.Sakamoto, R.Honda, Y.Kawakami,
Y.Yamashiro, Z.Jinsong, K.Sasaki, Japan-China Co-operative Study Group: Ｃｕｒｒｅｎｔ ｓｔａｔｕｓ ａｂｏｕｔ ｂｌｉｎｄｎｅｓｓ
ａｍｏｎｇ ｌｏｗ‐income farmers in Sanya district, hainan, China, Japanese journal of clinical ophthalmology Rinsho
ganka., 61:411-416, 2007 (in Japanese) .

0970B009

M.Fukuda, K.Yamamoto, N.Takahashi, H.Sasaki, M.Yoshikawa: Corneal disorder quantification by corneal
resistance, Journal of the eye., 24:521-525, 2007 (in Japanese) .

Others
0970F002

M.Kojima: Ultraviolet exposure as a risk factor in cataract formation, J & J, 1-2, 2007 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0970I001

K.Sasaki, H.Sasaki, R.Honda, Y.Kawakami, M.Kojima, Y.Sakamoto, J.Qu, Y.Yamashiro, J.Zhang, Z.Lilu: HighPrevalence of Pterygium in the Population of a Tropical Area in China -Sanya Eye Study-, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0970I002(A.M.Arnarsson), K.F.Damji, T.Sverrisson, H.Sasaki, F.Jonasson: Prevalence of pseudoexfoliation and association
with IOP, corneal thickness, and structural optic disc parameters in the Reykjavik eye study, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0970I003

H.Sasaki, Y.Sakamoto, E.Shibuya, T.Yamaguchi, Y.Kawakami, H.Nakaizumi, K.Sasaki: Deterioration of reading
performance and ocular higher order aberration in subjects with cortical cataract, Association for Research in
Vision and Ophthalmology, (Florida, '07.05).

0970I004

K.Nagai, H.Sasaki, R.Honda, M.Kojima, Y.Sakamoto, J.Qu, K.Sasaki: Prevalence of cataract in eyes with posterior
vitreous detachment, Association for Research in Vision and Ophthalmology, (Florida, '07.05).

0970I005

Y.Kawakami, H.Sasaki, Y.Sakamoto, M.Kojima, J.Qu, Z.Liu, J.Zhang, K.Sasaki: True exfoliation in chinese
population in a tropical area -The Sanya Eye Study-, Association for Research in vision and Ophthalmology,(Florida, '07.05).

0970I006

M.Fukuda, H.Sasaki: Intraocular penetration of moxifloxacin ophthalmic solution in rabbit eyes, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0970I007

M.Kojima, Y.Yamashiro, M.Hanazaw, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Investigation of frequency
specificity of ocular effects through quasi-millimeter and millimeter wave exposure, Association for Research in
Vision and Ophthalmology, (Florida, '07.05).

0970I008

J.Qu, H.Sasaki, Y.Kawakami, Y.Sakamoto, M.Kojima, J.Zhou, K.Wu, J.Zhang, R.Honda, K.Sasaki: The relationshipof axial length and three main types of cataract in the population of a tropical area of China, Association for
Research in Vision and Ophthalmology, (Florida, '07.05).

0970I009(H.Wakatsuchi), M.Hanazawa, T.Sakai, S.Watanabe, M.Kojima, Y.Yamashiro, K.Sasaki, O.Hashimoto: Complex
permittivities measurements of ocular tissues in quasi-millimeter and millinmeter wave bands, Bioelectromagnetics,(Kanazawa, '07.06).

0970I010

M.Kojima, M.Hanazawa, Y.Yamashiro, S.Watanabe, H.Sasaki, M.Taki, K.Sasaki: Possibility of frequency specificityof ocular effects by quasi-millimeter and, Bioelectromagnetics, (Kanazawa, '07.07).

0970I011

K.Kitagawa, N.Tomosugi, H.Tuchida, H.Sasaki: Automated identification and quantification of tear proteins from
Sjogern's syndrome by LC/MS on a hybrid linear ion trap mass spectrometer, 5th international Conference on the
Tear Film & Ocular Surface : Basic Science and Cliical Relevance, (Italy, '07.08).

0970I012

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki: Difference of ocular injury by millimetr wave exposure with different
frequency, European associatio for Vision and Eye Research, (Slovenia, '07.10).

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0970I013

K.Sasaki: Cataract classification systems, a critical review, European Association for Vision and Eye Research,(Slovenia, '07.10).

0970I014

H.Sasaki: Racial differences of lens trabsoarebct orioerties, European Association for Vision and Eye Research,(Slovenia, '07.10).

0970I015

Y.Sakamoto, H.Nakaizumi, N.Yamamoto, M.Sakamoto, H.Sasaki, K.Sasaki: Influence of the rilring of asphericintraocular lens on the ocular higher order aberration andf the contrast sensitivity function, US-Japan Cooperative
Cataract Research Group Meeting, (Hawaii, '07.12).

0970I016

K.Nagai, H.Sasaki, R.Honda, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: Change of light scattering intensity ineyes with posterior vitreous detachment, Monzen eye study, US-Japan Cooperative Cataract Research Group
Meeting, (Hawaii, '07.12).

0970I017

H.Kawada, M.Kojima, Y.Yamashiro, M.Fukuda, T.Kimura, S.Natori, K.Sasaki, H.Sasaki: Effect of 5-S-GAD (eyedrops) on UV-B-induced cataract in rats, US-Japan Cooperative Cataract Research Group Meeting, (Hawaii,'07.12).

0970I018

M.Kojima, Y.Yamashiro, Y.Sakamoto, Y.Kawakami, H.Sasaki, K.Sasaki: Difference of cataract development bydifferent frequency in millimeter wave, US-Japan Cooperative cataract Research Group Meeting, (, '07.12).

0970I019

H.Sasaki, N.Fujita, Y.Sakamoto, M.Kojima, J.Qu, N.Yamamoto, Y.Kawakami, K.Nagai, H.Nakaizumi, K.Sasaki:
Myopia induced by retrodots and nuclear caratact, US-Japan Cooperative Cataract Research Group Meeting,(Hawaii, '07.12).

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Kanazawa Medical University
Research Activities and Publications 2007
Published December, 2008
Issuer: Yuichi Yamada
Editer: Hideaki Nakagawa
Publishing office: Kanazawa Medical University Publication office
1-1 Daigaku,Uchinada-machi,Kahoku-gun,Ishikawa-ken,Japan,920-0293
Tel +81 76 286 2211(Representative)

Printing office: TANAKA&SHOBUNDO GRAPHIC ART Co.LTD.

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