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I
Code

Department

Basic

N
Page

Medicine

D

E

X

Code

Department

Page

0410

Department of Cardiovascular Surgery ･･････59

0100

Department of Anatomy Ⅰ･･････････････････1

0660

Department of Respirology (Thoracic Surgery)0110

Department of Anatomy Ⅱ･･････････････････20420

Department of Surgical Oncology ････････････62

0120

Department of Physiology Ⅰ ･･････････････････30430

Department of Orthopedics Surgery ･･････････65･･････････････････50440

Department of Neurosurgery ･････････････････68

0140

Department of Biochemistry Ⅰ ･･･････････････70450

Department of Plastic and Reconstructive

0150

Department of Biochemistry Ⅱ

0160

Department of Pharmacology ････････････････100460

Department of Pediatric Surgery ･･････････････72

0170

Department of Oncologic Pathology ･･････････110470

Department of Ophthalmology ････････････････73

0180

Department of Pathophysiological and

0480

Department of Otolaryngology ････････････････76

Experimental Pathology ････････････････････120490

Department of Dermatology ･･･････････････････78

0190

Department of Microbiology ･････････････････140500

Department of Urogenital Surgery ････････････80

0200

Department of Immunology ･･･････････････････160510

Department of Obstetrics and Gynecology ･････82

0210

Department of Medical Zoology ･･･････････････170520

Department of Anesthesiology and0220

Department of Pathology and Laboratory

0130 Department of Physiology Ⅱ･･60

Surgery ････････････････････････････････････70･･････････････8

Perioperative Medicine ･･････････････････････84

Medicine ･･･････････････････････････････････18

0650

Department of Rehabilitation Medicine ･･･････86

Department of Social and Environmental

0550

Department of Emergency Medicine ･･･････････87

Medicine ･･･････････････････････････････････20

0570

District medical ･････････････････････････････88

0240 Department of Epidemiology and Public Health ･･･220530

Department of Oral and Maxillofacial Surgery ･89

0230

0250

Department of Legal Medicine ･･･････････････26

0260

Department of Medical Education ････････････27

Clinical Medicine

Schoolof

Nursing

8010

Basic Nursing

8030

Psychiatric and Mental Health Nursing ･･･････92･････････････････････････････91

0300

Department of Cardiovascular Medicine ･･･････29

8040

Adult Nursing

0310

Department of Respirolgy (Respiratory Medicine)･･31

8050

Nursing of the Elderly

0320

Department of Gastroenterology ･････････････33

8060

Child Nursing ･･････････････････････････････96

0330

Department of Nephrology ････････････････････36

8070

Maternity Nursing

0340

Department of Endocrinology and Metabolism ･･38

8080

Community Nursing･････････････････････98

0350

Department of Hematology and Immunology ･･･41

8090

Home Care Nursing･･･････････････････････100

0360

Department of Neurology ･････････････････････44

8095

Comprehensive Nursing ････････････････････101

0560

Department of Medical Oncology ･･････････････46

8100

Human Science0565

Department of Infectious Diseases ････････････49

0630

Department of General Internal Medicine ･･････50

0370

Department of Geriatric Medicine ･････････････51

0380

Department of Pediatrics ････････････････････53

0390

Department of Neuropsychiatry ･･･････････････55

0400

Department of Diagnostic and Therapeutic
Radiology ･･･････････････････････････････････57････････････････････････････93･･････････････････････95･････････････････････････97････････････････････････102

Liberal0040

Department of Life Science(Natural Science:Physics)
0050

Arts

････････････････････105

Department of Life Science(Natural Science:Chemistry) ･････････････････106

0060

Department of Life Science(Natural Science:Biology) ････････････････････107

CodeDepartment

Page0090 Department of Life Science (Physical Education)･･1080010

Department of Human Science (Humanities) ･･1090030

Department of Human Science (Mathematics) ･1100070

Department of Human Science(Foreign Languages:English) ･････････････････111

0080

Department of Human Science(Foreign Languages:German) ･････････････････113

University

Hospital

0690

Department of Endoscopy ･･･････････････････115

0620

Department of Pathology ････････････････････116

0640

Endoscopy Center ･･･････････････････････････117

0700

Multidiscciplinary Cancer Center ･････････････118

0670

Lifestyle-related Diseases Center ････････････121

0610

Health Management Center ････････････････122

0680

Medical Genetic Center ･･････････････････････126

MedicalResearch

Institute

7100

Department of Life Science ･･････････････････127

7200

Department of Advanced Medicine ･･･････････130

7310

Division of HT Research ･････････････････････133

7320

Division of Vision Research forEnvironmental Health ･･･････････････135

7330

Division of Dermatomycology ････････････････137

AffiliatedInstitution

9050

Center for FDD-MB ･････････････････････････139

9030

North Noto Institute of Community Medicine ･･140

Himi
9100

Municipal

Himi Municipal Hospital

Hospital･･････････････････141

Code

Department

Page

Basic Medicine

0100Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Associate Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001(R.Hashimoto), J.Udagawa, Y.Kagohashi, A.Matsumoto, T.Hatta, H.Otani: Direct and indirect effects ofneuropeptide Y and neurotrophin 3 on myelination in the neonatal brains, Brain Res., 1373:55-66, 2011.

Reviews
0100C001

E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta: Effects of melanocortins on fetal development, Congenit.
Anom. (Kyoto), 51:47-54, 2011.

Presentations at Conference
International Conference (Presentations)
0100I001

E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta: Maternal-placental-fetal leukemia inhibitory factor signal
pathway contributes stage-specific differentiation from fetal neural stem/progenitor cells to astrocytes, Society for
Neuroscience 2011, (Washington, '11.11).

0100I002

T.Hatta, H.Shimada, E.Simamura, H.Shoji, N.Higashi: Leukemia inhibitory factor induces expression of insulin-likegrowth factor 1 and 2 in the forebrain of rat fetuses via maternal-fetal leukemia inhibitory factor signal pathway,
Society for Neuroscience 2011, (Washington, '11.11).

- 1 -

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy, embryology, lymphatic vessels, microscopy

Associate Professor

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy, central nervous system

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry, pituitary, cell proliferation, electron
microscopy

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

Publications
Reviews
0110C002

H.Shinohara: Fundamentals of white matter dissection, Jpn. J. Neursurg, 20(suppl2):105-110, 2011 (in Japanese) .

- 2 -

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Associate Professor

SUGAI Tokio

Neurophysiology

Assistant Professor

YAMAMOTO Ryo

Neuroscience

Researcher

WANG Furong

Researcher

LUO Xianwen

Analysis of Alzheimer disease model mice in search for new
therapeutic approaches
Analysis of Alzheimer disease model mice in search for new
therapeutic approaches

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001

K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato: Suppression of aneocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, J. Neurosci.,
31:11100-11109, 2011.

0120B002

H.Yoshimura, M.Honjyo, T.Sugai, K.Kaneyama, N.Segami, N.Kato: Correlation between stimulation strength andonset time of signal traveling within the neocortical neural circuits under caffeine application, Neurosci. Res.,
70:370-375, 2011.

0120B003

H.Yoshimura, M.Honjyo, T.Sugai, M.Kawabe, K.Kaneyama, N.Segami, N.Kato: Influences of audio-visualenvironments on feelings of deliciousness during having sweet foods: an electroencephalogram frequency analysis
study, Nutr. Neurosci., 14:210-215, 2011.

- 3 -0120B004

P.Sun, F-R.Wang, L.Wang, Yu.Zhang, R.Yamamoto, T.Sugai, Q.Zhang, Z-D.Wang, N.Kato: Increase in corticalpyramidal cell excitability accompanies depression-like behavior in mice: a transcranial magnetic stimulation study,
J. Neurosci., 31:16464-16472, 2011.

Presentations at Conference
International Conference (Presentations)
0120I001

T.Okuda, Y.Tachi, N.Kawahara, N.Kato, Y.Ishigaki, E.Hatano, Y.Yasuda, T.Matsumoto: Hyaluronidase-4
expression in a rat spinal cord hemisection model, Second Annual Meeting of Cervical Spine Research Society Asia
Pacific Section (CSRS-AP 2011), (Busan, '11.04).

0120I002

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Hato, E.Hatano, T.Matsumoto: Does Hyaluronidase-4
digest chondroitin sulfate proteoglycans in a rat spinal cord hemisection model?, Neuroscience 2011, (Washington,'11.11).

- 4 -

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

MIYAMAE Shunichi

Cardiac Electrophysiology

Researcher

KUDA Yuichi

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno: Effects of β-adrenoceptor antagonists on anaphylactic hypotension
in conscious, Eur. J. Pharmacol., 650:303-308, 2011.

0130B002

W.Zhang, T.Shibamoto, Y.Kuda, C.Omukai, Y.Kurata: Pulmonary vasoconstrictive and bronchoconstrictive
responses to anaphylaxis are weakened via β2-adrenoceptor activation by endogenous epinephrine in anesthetized
rats, Anesthesiology, 114:614-623, 2011.

0130B003

C.Kamikado, T.Shibamoto, W.Zhang, Y.Kuda, C.Omukai, Y.Kurata: Portacaval shunting attenuates portal
hypertension and systemic hypotension in rat anaphylactic shock, J. Physiol. Sci., 61:161-166, 2011.

0130B004

T.Shibamoto, M.Tsutsumi, C.Omukai, Y.Kuda, W.Zhang, Y.Kurata: Ethanol predominantly constricts presinusoids of isolated perfused livers of rat, guinea pig and mouse, Alcohol Alcohol., 46:117-122, 2011.

0130B005(T.Urashima), Y.Kurata, J.Miake, M.Kato, K.Ogura, A.Yano, M.Adachi, Y.Tanaka, K.Yamada, T.Hamada,
E.Mizuta, M.Kuwabara, M.Kato, Y.Yamamoto, K.Ogino, A.Yoshida, Y.Shirayoshi, I.Hisatome: Enhancing effects ofsalicylate on quinidine-induced block of human wild type and LQT3 related mutant cardiac Na+ channels, Biomed.
Res., 32:303-312, 2011.

- 5 -0130B006(U.Bahrudin), K.Morikawa, A.Takeuchi, Y.Kurata, J.Miake, E.Mizuta, K.Adachi, K.Higaki, Y.Yamamoto,Y.Shirayoshi, A.Yoshida, M.Kato, K.Yamamoto, E.Nanba, H.Morisaki, T.Morisaki, S.Matsuoka, H.Ninomiya,
I.Hisatome: Impairment of ubiquitin-proteasome system by E334K cMyBPC modifies channel proteins, leading toelectrophysiological dysfunction, J. Mol. Biol., 413:857-878, 2011.

0130B007(YK.Ting), K.Morikawa, Y.Kurata, P.Li, U.Bahrudin, E.Mizuta, M.Kato, J.Miake, Y.Yamamoto, A.Yoshida,
M.Murata, T.Inoue, A.Nakai, G.Shiota, K.Higaki, E.Nanba, H.Ninomiya, Y.Shirayoshi, I.Hisatome: Transcriptional
activation of the anchoring protein SAP97 by heat shock factor (HSF)-1 stabilizes K(v) 1.5 channels in HL-1
cells., Br. J. Pharmacol., 162:1832-1842, 2011.

0130B008(P.Li), H.Ninomiya, Y.Kurata, M.Kato, J.Miake, Y.Yamamoto, O.Igawa, A.Nakai, K.Higaki, F.Toyoda, J.Wu,
M.Horie, H.Matsuura, A.Yoshida, Y.Shirayoshi, M.Hiraoka, I.Hisatome: Reciprocal control of hERG stability by
Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability, Circ. Res., 108:458-468, 2011.

Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, W.Zhang, Y.Kurata: Pulmonary vaso- and broncho-constrictive responses to anaphylaxis areattenuated by b2-adrenoceptor activation by endogenous catecholamines in the anesthetized rats, 2011 American
Thoracic Society International Conference, (Denver, '11.05).

0130I002

T.Shibamoto: The responses of the hepatic and splanchnic vascular beds to vasopressin in mice, as compared withthat in rats., The 7th Congress of the Federation of Asian and Oceanian Physiological Societies, (Taipei, '11.10)，
Abstract, 415, 2011.

- 6 -

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Faculty

Professor

DATE Takayasu

Function of protein Kinase, PKU-β/TLK1 and PKU-α/TLK2

Senior Assistant Professor

HASHIMOTO
Mitsumasa

Cell biology, DNA repair, Cell cycle, p53-binding proteins

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SUNATANI Yumi

Molecular biology, DNA repair, p53-binding proteins

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

- 7 -

0150

Department of Biochemistry Ⅱ

Name

Field of Specialization

Faculty
Title
Professor

Molecular mechanisms of angiogenesis, Alternative mRNA processing,MicroRNA function
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein
YONEKURA Hideto

Associate Professor
Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura: Ultraviolet B-induced
expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, Mol. Vis., 17:159169, 2011.

0150B002(Y.Yamamoto), A.Harashima, H.Saito, K.Tsuneyama, S.Munesue, S.Motoyoshi, D.Han, T.Watanabe, M.Asano,S.Takasawa, H.Okamoto, S.Shimura, T.Karasawa, H.Yonekura, H.Yamamoto: Septic shock is associated withreceptor for advanced glycation end products ligation of LPS, J. Immunol., 186:3248-3257, 2011.

0150B003

H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura: Identification of the COL2A1 mutation inpatients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, Genet. Test.
Mol. Biomarkers, 15:231-237, 2011.

0150B004

T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura: Hypoxia down-regulates sFlt-1(sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative
processing, Biochem. J., 436:399-407, 2011.

0150B005

K.Yamamoto, Y.Ueta, L.Wang, R.Yamamoto, N.Inoue, K.Inokuchi, A.Aiba, H.Yonekura, N.Kato: Suppression of aneocortical potassium channel activity by intracellular amyloid-β and its rescue with homer1a, J. Neurosci.,
31:11100-11109, 2011.

- 8 -Presentations at Conference
International Conference (Synposium)
0150H001

T.Ikeda, Y.Yoshitomi, Y.Ishigaki, Y.Yoshitake, H.Yonekura: Soluble VEGFR-1 production is down-regulated underhypoxia in human microvascular endothelial cells by a mechanism involving alternative mRNA 3′-end processing,
The Molecular Biology Society of Japan The 11th Spring Symposium International Symposium on Tumor Biology in
Kanazawa, (Kanazawa, '11.05).

International Conference (Presentations)
0150I001

T.Ikeda, Y.Yoshitomi, Y.Ishigaki, Y.Yoshitake, H.Yonekura: Hypoxia doun-regulates sFlt-1(sVEGFR-1)
expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, 36th
FEBS Congress, (Torino, '11.06).

0150I002

Y.Yoshitake, H.Osada, T.Ikeda, Y.Yoshitomi, Y.Ishigaki, H.sasaki, H.Yonekura: Ultraviolet B-induced expressionof amphiregulin and growth differentiation factor 15 in human lens epithelial cells, 36th FEBS Congress, (Torino,'11.06).

- 9 -

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor (Additional Post)

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Senior Assistant Professor

MASUOKA Takayoshi

Researcher

ABE Fusae

Researcher

IMAIZUMI Noriko

Field of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystem.
Pharmacology in cardiovascular system, Cancer chemotherapy.
Electrophysiology and behavioural pharmacology in central andperiphenal nervous system
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy.

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary circulation,
nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug,
proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

T.Ishibashi, N.Nishizawa, M.Nakamoto, F.Abe, H.Liu, J.Yoshida, T.Kawada, M.Nishio: Differrent disappearance
rates of plasma nitrite (NO2-) contribute to apparent steady-state arterio-venous differences in anesthetizedanimals, Biol.Pharm.Bull., 34:528-537, 2011.

0160B002

T.Ishibashi, T.Miwa, N.Nishizawa, I.Shinkawa, J.Yoshida, T.Kawada, M.Nishio: Role of plasma S-nitrosothiols in
regulation of blood pressure in anesthetized rabbits with special references to hypotensive effects of acetylcholine
and nitrovasodilators, Biol.Pharm.Bull., 34:1307-1313, 2011.

- 10 -

0170

Department of Oncologic Pathology

Faculty
Title

Name

Field of Specialization

Professor (Additional Post)

KOHNO Hiroyuki

Experimental pathology, Tumor immunology.

Assistant Professor

OYAMA Takeru

Mechanisms of carcinogenesis.

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Publications
Originals
0170B001

W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno: Effects of β-adrenoceptor antagonists on anaphylactic hypotension
in conscious, Eur. J. Pharmacol., 650:303-308, 2011.

Presentations at Conference
International Conference (Presentations)
0170I001(A.Sakurai), M.Matsuda, E.Kiyokawa: Mechanism of Ras-induced polyp formation in vitro, FASEB Summer
Research Conference on Gastrointestinal Tract XIV: Stem Cells, Adaptation, Inflammation & Cancer, (Colorado,'11.08).

0170I002(R.Mizuno), E.Kiyokawa, Y.Sakai, M.Matsuda: Live imaging of the mouse intestine with two-photon excitation
microscopy, FASEB Summer Research Conference on Gastrointestinal Tract XIV: Stem Cells, Adaptation,
Inflammation & Cancer, (Colorado, '11.08).

- 11 -

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology.

Associate Professor

SATO Katsuaki

Neuropathology.

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer.

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

Y.Machida, Y.Ueda, M.Shimasaki, K.Sato, M.Sagawa, S.Katsuda, T.Sakuma: Relationship of aquaporin 1,3,and 5
expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential, Hum. Pathol.,
42:669-678, 2011.

0180B002(N.Nese), G.Martignoni, C.D.Fletcher, R.Gupta, C-C.Pan, H.Kim, J.Y.Ro, I..S.Hwang, K.Sato, F.Bonetti, M.Pea,
M.B.Amin, O.Hes, A.Svec, M.Kida, M.Vankalakunti, D.Berel, A.Rogatko, A.M.Gown, M.B.Amin: Pure epithelioid
PEComas (so-called epithelioid angiomyolipoma) of the kidney: A clinicopathologic study of 41 cases: detailed
assessment of morphology and risk stratification, Am. J. Surg. Pathol., 35:161-176, 2011.

0180B003

K.Usuda, Xi.Zhao, M.Sagawa, M.Matoba, Y.Kuginuki, M.Taniguchi, Y.Ueda, T.Sakuma: Diffusion-weighted imaging
is superior to positron emission tomography in the detection and nodal assessment of lung cancers, Ann. Thorac.
Surg., 91:1689-1695, 2011.

0180B004

M.Yamada, H.Shiroeda, R.Hayashi, H.Yano, K.Sato, M.Tsutsumi, T.Arisawa: Survival rates of early-stage HCVrelated liver cirrhosis patients without hepatocellular carcinoma are decreased by alcohol, J. Clin. Biochem. Nutr.,
48:167-169, 2011.

0180B005(J.F.Guo), K.Higashi, Y.Ueda, Y.Ishigaki, T.Sakuma, M.Oguchi, T.Takegami, Y.Ohta, L.Zhang, K.Xu, H.Nishida,
H.Tonami: VEGF-A and its isoform VEGF121 mRNA expression measured by quantitative real-time RT-PCR:
correlation with F-18 FDG uptake and aggressiveness of lung adenocarcinoma: preliminary study, Ann. Nucl.
Med., 25:29-36, 2011.

- 12 -

0180B006

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

Case Reports
0180D001

S.Maeda, M.Sugita, M.Sagawa, Y.Ueda, T.Sakuma: Solitary fibrous tumor of the pleura suddenly induced
hypoglycemia before surgical treatment, Ann. Thorac. Cardiovasc. Surg., 17:293-296, 2011.

0180D002

M.Yamada, H.Shiroeda, T.Nomura, R.Hayashi, K.Sato, M.Tsutsumi, T.Arisawa: Colon cancer arising in an ulcer
scar due to intestinal Behçet's disease, Intern. Med., 50:429-32, 2011.

0180D003

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Astumi, H.Minato, K.Sato:
Adrenal myelolipoma: A report of two cases, J. Kanazawa. Med. Univ., 36:86-89, 2011 (in Japanese) .

0180D004

I.Chikazawa, T.Tanaka, K.Suzuki, K.Sato: A case of renal oncocytonma with cystic change, Japanese Journal of
Clinical Urology, 65:1031-1033, 2011 (in Japanese) .

Short Communications
0180E001

T.Ichiseki, A.Kaneuji, Y.Ueda, S.Nakagawa, T.Mikami, K.Fukui, T.Matsumoto: Osteonecrosis development in anovel rat model characterized by a single application of oxidative stress, Arthritis Rheum, 63:2138-2141, 2011.

Others0180F001

M.Yamada, H.Shiroeda, K.Sato, R.Hayashi, T.Nomura, M.Tsutsumi, T.Arisawa: Accelerated progression ofhepatocellular carcinoma with cytokeratin 19 expression during treatment with lamivudine for hepatitis B virusrelated liver cirrhosis, Scand. J. Gastroenterol., 45:249-251, 2011.

Presentations at Conference
International Conference (Presentations)
0180I001

M.Shimasaki, Y.Ueda, K.Sato: Relationship of aquaporin 1, 3 and 5 expression in lung cancer cells to cellulardifferentiation, invasive growth and metastasis potential., Congress of European Respiratory Society 2011,(Amsterdam, '11.08).

0180I002(Y.Kanazawa), Y.Ueda, M.Shimasaki: Involvement of aquaporin 1 and 5 overexpression in metastasis potential of
human osteosarcoma., International Society of Lim Salbage, (Beijing, '11.09).

- 13 -

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology, Neuroimmunology.

Associate Professor

MURAKI Yasushi

Virology.

Senior Assistant Professor

HIMEDA Toshiki

Neurovirology.

Assistant Professor

OKUWA Takako

Virology.

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

T.Himeda, T.Okuwa, M.Nojiri, Y.Muraki, Y.Ohara: The anti-apoptotic protein L* of Theiler’s murine
encephalomyelitis virus (TMEV) contains a mitochondrial targeting signal, Virus Res., 155:381-388, 2011.

0190B002

Y.Muraki, T.Okuwa, T.Furukawa, Y.Matsuzaki, K.Sugawara, T.Himeda, S.Hongo, Y.Ohara: Palmitoylation of CM2
is dispensable to influenza C virus replication, Virus Res., 157:99-105, 2011.

0190B003

T.Himeda, T.Hosomi, N.Asif, H.Shimizu, T.Okuwa, Y.Muraki, Y.Ohara: The Preparation of an infectious fulllength cDNA clone of saffold virus, Virol. J., 8:110, 2011.

0190B004(T.Furukawa), Y.Muraki, T.Noda, E.Takashita, R.Sho, K.Sugawara, Y.Matsuzaki, Y.Shimotai, S.Hongo: Role of theCM2 protein in the Influenza C virus replication cycle, J. Virol., 85:1322-1329, 2011.

Reviews
0190C001

T.Himeda, Y.Ohara: Roles of two non-structural viral proteins in virus-induced demyelination, Clin. Exp.
Neuroimmunol., 2:49-58, 2011.

Others
0190F001

Y.Ohara, T.Himeda: A new member of Cardiovirus: Unknown pathogenicity to humans, J. Plant. Pathol. Microbiol.,
2:4, 2011.

0190F002

T.Himeda, M.Nojiri, T.Okuwa, Y.Muraki, Y.Ohara: Reverse genetic analysis of the recombination in theilovirus
based on the infectious cDNA clones, J. Plant. Pathol. Microbiol., 2:4, 2011.

- 14 -

Presentations at Conference
International Conference (Presentations)
0190I001

Y.Muraki, T.Okuwa, T.Himeda, Y.Ohara: The cysteine residues in the eztracellular domain of CM2 are dispensable
but influence the influenza C virus replication., XV International Congress of Virology, (Sapporo, '11.09).

0190I002

T.Himeda, T.Hosomi, N.Asif, H.Shimizu, T.Okuwa, Y.Muraki, Y.Ohara: Synthesis of infectious Saffold virus type 3
RNA by T7 RNA polymerase in terminated by a human prepraparathyroid hormone (PTH) signal in the viralgenome, XV International Congress of Virology, (Sapporo, '11.09).

0190I003

T.Okuwa, Y.Muraki, T.Himeda, Y.Ohara: Glycosylation of influenza C virus CM2 protein affects the early phase ofviral replication, XV International Congress of Virology, (Sapporo, '11.09).

- 15 -

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology.

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology.

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

Publications
Reviews
0200C001

A.Nakamura: Regulation of immune responses by inhibitory receptors, J. Kanazawa. Med. Univ., 36:11-18, 2011
(in Japanese) .

- 16 -

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Senior Assistant Professor

ICHIKAWA Hidetaka Immunological study for parasitic diseases

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.2.Epidemiological research of tickborn diseases in the Noto Peninsula,Ishikawa Prefect.

Publications
Originals
0210B001(A.Takano), M.Nakao, T.Masuzawa, N.Takada, Y.Yano, F.Ishiguro, H.Fujita, T.Ito, X.Ma, Y.Oikawa, F.Kawamori,
K.Kumagai, T.Mikami, N.Hanaoka, S.Ando, N.Honda, K.Taylor, T.Tsubota, S.Konnai, H.Watanabe, M.Ohnishi,
H.Kawabata: Multilocus sequence typing implicates rodents as the main reservoir host of human-pathogenic
Borrelia garinii in Japan, J. Clin. Microbiol., 49:2035-2039, 2011.

Presentations at Conference
International Conference (Presentations)
0210I001

M.Murakami, K. Kamimura, Y.Oikawa, T.Takegami: Isolation and characterization of Japanese encephalitis virus
from mosquitoes in Ishikawa, Japan in 2010, XV International Congress of Virology, (Sapporo, '11.09).

- 17 -

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Assistant Professor

KINOSHITA Erikosurgical pathology, molecular pathology

Assistant Professor

NAKADA Satoko

surgical pathology

Assistant Professor

FUKUSHIMA Mana

surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001(T.Daniels), D.Cox, C.Shiboski, M.Schiodt, A.Wu, H.Lanfranchi, H.Umehara, Y.Zhao, S.Challacombe, M.Lam,
Y.Souza, J.Schiodt, H.Holm, P.Bisio, M.Gandolfo, T.Sawaki, M.Li, W.Zhang, B.Varghese-Jacob, P.Ibsen,
A.Keszler, N.Kurose, T.Nojima, E.Odell, L.Criswell, R.Jordan, J.Greenspan: Associations between salivary glandhistopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants,
Arthritis Rheum, 63:2021-2030, 2011.

0220B002

Y.Masaki, M.Miki, Y.Sun, T.Nakamura, H.Iwao, A.Nakajima, N.Kurose, T.Sakai, Z.Jin, T.Sawaki, T.Kawanami,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: High-dose methotrexate with R-CHOP therapy for thetreatment of patients with primary central nervous system lymphoma, Int. J. Hematol., 93:720-726, 2011.

Reviews
0220C001

Y.Masaki, N.Kurose, H.Umehara: IgG4-related disease: a novel lymphoproliferative disorder discovered andestablished in Japan in the 21st century, J. Clin. Exp. Hematop., 51:13-20, 2011.

- 18 -

Case Reports
0220D001(S.Tanaka), M.Nakada, Y.Hayashi, S.Nakada, S.Sawada-Kitamura, N.Furuyama, T.Suzuki, T.Kamide, Y.Hayashi,
S.Yano, J.Hamada: Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT
promoter and 5-ALA fluorescence, Brain Tumor Pathol., 28:59-64, 2011.

0220D002(J.Shimizu), Y.Arano, I.Adachi, M.Morishita, B.Fuwa, M.Saitoh, H.Minato: Adenosquamous carcinoma of the lungin a patient with complete situs inversus, Ann. Thorac. Cardiovasc. Surg., 17:178-81, 2011.

0220D003(H.Suzuki), K.Yamashiro, H.Takeda, T.Nojima, M.Usui: Extra-axial soft tissue chordoma of wrist, Pathol. Res.
Pract., 207: 327-331, 2011.

0220D004(I.Ishikawa), K.Morita, S.Hayama, T.Nakagawa, I.Araki, K.Higashi, K.Miyazawa, K.Suzuki, T.Nojima: Imaging ofacquired cystic disease-associated renal cell carcinoma by contrast-enhanced ultrasonography with perflubutane
microbubbles and positron emission tomography-computed tomography, Clin. Exp. Nephrol., 15:136-140, 2011.

0220D005

A.Tempaku, T.Mizuno, M.Hasegawa, A.Saito, N.Yamashita, H.Atsumi, T.Ito, K.Ishigami, M.Miura, Y.Izumi,
N.Kurose, H.Minato, T.Nojima, T.Kanda, N.Takekoshi: Interleukin-6 expressing colon cancer with multiple hepatic
metastases, J. Kanazawa. Med. Univ., 36:106-110, 2011.

0220D006

E.Kinoshita, N.Kurose, H.Minato, T.Nojima, Y.Nakano: Clear cell adenocarcinoma coexisting with squamous cell
carcinoma in situ of the uterine cervix-A case report-, J. Jpn. Soc. Clin. Cytol., 50:132-133, 2011 (inJapanese) .

0220D008

N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo: A Case of primary cardiac
angiosarcoma associated with cardiac tamponade, Cancer & chemotherapy., 38:1353-1355, 2011 (in Japanese) .

0220D009

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, A.Nakagawa, N.Kurose: Composite pheochromocytoma withganglioneuroma in the adrenal gland: A case report, J. Kanazawa. Med. Univ., 36:83-85, 2011 (in Japanese) .

0220D010

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Astumi, H.Minato, K.Sato:
Adrenal myelolipoma: A report of two cases, J. Kanazawa. Med. Univ., 36:86-89, 2011 (in Japanese) .

0220D011

M.Kaito, H.Iwao, E.Kinoshita, H.Funaki, O.Tachibana, M.Matsui: A case of Castleman disease with statusepileptics originating from focal cortical dysplasia, Clinical Neurology, 51:487-492, 2011 (in Japanese) .

Others
0220F001

H.Minato, T.Nojima, M.Nakano, M.Yamazaki: Safety management in pathology laboratory: from specimen handlingto confirmation of reports, Rinsho Byori, 59:299-304, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0220I001

Y.Ono, T.Onishi, Y.Tomita, M.Yokoi, H.Funaki, S.Kinami, K.Omote, N.Ueda, Y.Nakano, M.Noguchi, T.Kosaka,
N.Kurose: A breast cancer case having metastasis to the intramammary sentinel lymph node, The International
college of Surgeons The 57th Annual congress of the Japan section and the 27th colorectal conference in Aichi,(Nagoya, '11.06)，The International college of Surgeons The 57th Annual congress of the Japan section and the27th colorectal conference in Aichi proceedings, 68, 2011.

0220I002

H.Minato, N.Kurose, M.Fukushima, T.Nojima, M.Ueno, K.Usuda, M.Sagawa, T.Sakuma: Hepatoid adenocarcinoma
with a peripheral mucinous bronchioloalveolar growth pattern, 2011 Pulmonary pathology society biennial meeting,(New York, '11.08).

0220I003

Y.Masaki, N.Kurose, S.Sugai, H.Umehara: Analysis of serum IgG4 cut-off value to distinguish Sjögren's syndromefrom IgG4-related disease, 11th International symposium on Sjögren's syndrome, (Athens, '11.09).

- 19 -

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stress

Associate Professor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Senior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Senior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Association between long working hours and sleep problems in white-collar workers, J. Sleep. Res.,
20:110-116, 2011.

0230B002

Y.Hamazaki, Y.Morikawa, K.Nakamura, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: The effects of sleep duration on the incidence of cardiovascular events among middle-aged maleworkers in Japan, Scand. J. Work Environ. Health, 37:411-417, 2011.

Reviews
0230C001

Y.Noborisaka, M.Ishizaki, Y.Yamada: Paradoxical signs of smoking-induced chronic kidney disease (CKD) in
generally healthy populations, especially those from workplaces, J. Kanazawa. Med. Univ., 36:98-105, 2011.

0230C002

Y.Yamada, Y.Noborisaka, M.Ishizaki: Cigarette smoking and renal damage -recent knowledge from epidemiologicalstudies, J. Kanazawa. Med. Univ., 36:1-10, 2011 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0230H001

M.Nakata: Criteria for acknowledgement and compensation for occupational musculoskeletal disorders in Japan,
and their related arguments, The first Japan-Korea joint symposium on Work-related Musculoskeletal Disorders,(Hiroshima, '11.02).

- 20 -

International Conference (Presentations)
0230I001

Y.Morikawa, M.Sakurai, K.Nakamura, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Sift work and heavy drinking,
Biological mechanisms,recovery and risk management in the 24th society, (Stockholm, '11.07).

- 21 -

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor (Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate Professor

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure

NAKANISHI Yumiko

Preventive medicine

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology.

Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

0240B002(Y.Murakami), K.Miura, T.Okamura, H.Ueshima, H.Nakagawa, and for the EPOCH-JAPAN Research Group:
Population attributable numbers and fractions of deaths due to smoking: A pooled analysis of 180,000 Japanese,
Prev. Med., 52:60-65, 2011.

0240B003(D.D.Nhu), T.Kido, N.N.Hung, L.T.H.Thom, R.Naganuma, L.K.Son, S.Honma, S.Maruzeni, M.Nishijo,
H.Nakagawa: Dioxin levels in the breast milk and estradiol and androgen levels in the saliva of Vietnameseprimiparae, Toxicol. Environ. Chem., 93:824-838, 2011.

0240B004

Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi,
S.Miyazawa, S.Kuwabata: Ionic liquid enables simple and rapid sample preparation of human culturing cells forscanning electron microscope analysis, Microsc. Res. Tech., 74:415-420, 2011.

- 22 -

0240B005

K.Tawara, M.Nishijo, S.Maruzeni, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, D.D.Nhu, N.N.Hung,
L.T.H.Thom: Residual congener pattern of dioxins in human breast milk in southern Vietnam, Chemosphere,
84:979-986, 2011.

0240B006

P.T.Tai, M.Nishijo, T.Kido, H.Nakagawa, S.Maruzeni, R.Naganuma, N.T.N.Anh, Y.Morikawa, H.V.Luong,
T.H.Anh, N.N.Hung, L.K.Son, K.Tawara, H.Nishijo: Dioxin concentrations in breast milk of Vietnamese nursing
mothers: a survey four decades after the herbicide spraying, Environ. Sci. Technol., 45:6625-6632, 2011.

0240B007

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

0240B008

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi,
S.Kuwabata, S.Miyazawa: Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured
human cells by scanning electron microscopy., Microsc. Res. Tech., 74:1104-1108, 2011.

0240B009(J.D.Curb), H.Ueshima, B.L.Rodriguez, Q.He, T.A.Koropatnick, H.Nakagawa, K.Sakata, S.Saitoh, A.Okayama, for
the INTERLIPID study group: Differences in lipoprotein particle subclass distribution for Japanese Americans in
Hawaii and Japanese in Japan: the INTERLIPID study, J. Clin. Lipidol., 5:30-36, 2011.

0240B010

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Association between long working hours and sleep problems in white-collar workers, J. Sleep. Res.,
20:110-116, 2011.

0240B011

M.Sakurai, J.Stamler, K.Miura, I.J.Brown, H.Nakagawa, P.Elliott, H.Ueshima, Q.Chan, I.Tzoulaki, A.r.Dyer,
A.Okayama, L.Zao, for the INTERMAP Research Group: Relationship of dietary cholesterol to blood pressure:the
INTERMAP stydy, J. Hypertens., 29:222-228, 2011.

0240B012

M.Nagai, Y.Morikawa, K.Kitaoka, K.Nakamura, M.Sakurai, M.Nishijo, Y.Hamazaki, S.Maruzeni, H.Nakagawa:
Effects of fatigue on immune function in nurses performing shift work, J. Occup. Health, 53:312-319, 2011.

0240B013

Y.Hamazaki, Y.Morikawa, K.Nakamura, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: The effects of sleep duration on the incidence of cardiovascular events among middle-aged maleworkers in Japan, Scand. J. Work Environ. Health, 37:411-417, 2011.

0240B014(M.Sugihara), R.Oka, M.Sakurai, K.Nakamura, T.Moriuchi, S.Miyamoto, Y.Takeda, K.Yagi, M.Yamagishi: Agerelated changes in abdominal fat distribution in Japanese adults in the general population, J. Int. Med., 50:679685, 2011.

0240B015(The Emerging Risk Factors Collaboration), D.Wormser, S.Kaptoge, E.A.Di, E.Angelantonio, AM.Wood,
L.Pennells, A.Thompson, N.Sarwar, JR.Kizer, DA.Lawlor, BG.Nordestgaard, P.Ridker, V.Salomaa, J.Stevens,
M.Woodward, N.Sattar, R.Collins, SG.Thompson, G.Whitlock, J.Danesh, H.Nakagawa, M.Sakurai, K.Nakamura,
Y.Morikawa: Separate and combined associations of body-mass index and abdominal adiposity with cardiovasculardisease: collaborative analysis of 58 prospective studies, Lancet, 377:1085-1095, 2011.

0240B016(A.Kadota), K.Miura, T.Okamura, A.Hozawa, Y.Murakami, A.Fujiyoshi, N.Takashima, T.Hayakawa, Y.Kita,
A.Okayama, Y.Nakamura, H.Ueshima, H.Nakagawa, for the NIPPON DAYA90 research group: Relationship ofmoderate metabolic risk factor clustering to cardiovascular disease mortality in non-lean Japanese:A 15-year
follow-up of NIPPON DATA90, Atherosclerosis, 215:209-213, 2011.

0240B017

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Ke Le: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, Organohalogen Compounds., 73:1745-1748, 2011.

0240B018(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: High cadmium
exposure in Mae Sot’s population is associated with high anemia prevalence, Thai J. Toxicology, 26:29-43, 2011.

0240B019

Q.Li, M.Nishijo, H.Nakagawa, Y.Morikawa, M.Sakurai, K.Nakamura, T.Kido, K.Nogawa, M.Dai: Relationshipbetween urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study inJapan, Chin. Med. J., 124:3504-3509, 2011.

- 23 -

0240B020(T.Kido), R.Naganuma, XL.Sun, S.Maruzeni, HD.Manh, E.Koh, H.Suzuki, M.Nishijo, H.Nakagawa, S.Honma,
DD.Nhu, LTH.Thom, NN.Hung, LK.Son: Comparison of prostate specific antigen levels in serum between
herbicides/dioxin-hot spot and non-sprayed areas in Vietnam, Organohalogen Compounds., 73:1729-1732, 2011.

0240B021

M.Nishijo, K.Tawara, T.Seto, Y.Morikawa, R.Naganuma, T.Kido, A.Nguen Thi Nguyet, H.Nakagawa: Relationships
between food intake and dioxin concentrations in breast milk of motehrs in Ishikawa prefecture, Japan, Hokuriku
Japanese Journal of Public Health., 38:1-8, 2011 (in Japanese) .

0240B022(Y.Ohashi), K.Shimamoto, S.Sato, H.Iso, Y.Kita, A.Kitamura, I.Saito, Y.Kiyohara, H.Kawano, H.Nakagawa,H.Toyoshima, T.Ando, M.Taguri, A.Harada, H.Ueshima: Association of obesity and other cardiovascular risk
factors with stroke The Japan Arteriosclerosis Longitudinal Study- Exisiting Cohorts Combined (JALS-ECC),
Japanese Journal of Public Health., 58:1007-1015, 2011 (in Japanese) .

Reviews
0240C001

M.Sakurai: Impact of metabolic syndrome on the risk of atherosclerosis, Hokuriku Japanese Journal of Public
Health., 37:21-26, 2011 (in Japanese) .

Short Communications
0240E001(Y.Suwazono), K.Nogawa, M.Uetani, K.Miura, K.Sakata, A.Okayama, H.Ueshima, J.Stamuler, H.Nakagawa:Application of hybrid approach for estimating the benchmark dose of urinary cadmium for adverse renal effects in
the general population of Japan, J. Appl. Toxicol., 31:89-93, 2011.

0240E002(Y.Suwazono), K.Nogawa, M.Uetani, T.Kido, H.Nakagawa: Reassessment of the threshold of urinary cadmium byusing hybrid approach in a cadmium non-pulluted area in Japan, Int. J. Hyg. Environ. Health., 214:175-178, 2011.

0240E003(Y.Nakade), T.Takamura, M.Sakurai, H.Misu, M.Nagata, Y.Nanbu, H.Oe, T.Takamura, Y.Sakai, S.Kaneko,
T.Wada: Association between coefficients of variation of the R-R intervals on electrocardiograms and postchallenge hyperglycemia in patients with newly diagnosed type 2 diabetes, JDI., 2:324-327, 2011.

0240E004(Y.Suwazono), K.Nogawa, M.Uetani, S.Nakada, T.Kido, H.Nakagawa: Application of the hybrid approach to thebenchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted
areas in Japan, Environ. Res., 111:312-314, 2011.

Presentations at Conference
International Conference (Presentations)
0240I001(Y.Nakamura), Y.Kiyohara, T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, S.Nagasawa, K.Miura,
H.Ueshima, for the NIPPON DATA Research Group: Saturated Fatty Acids Intake and Coronary Heart Disease
Mortality in Japan: NIPPON DATA90 1990-2005. Nutrition, Physical Activity and Metabolism, Cardiovascular
Disease Epidemiology and Prevention 2011 Scientific Sessions, American Heart Association, (Atlanta, USA,'11.03).

0240I002

Y.Morikawa, M.Sakurai, K.Nakamura, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Sift work and heavy drinking,
Biological mechanisms,recovery and risk management in the 24th society, (Stockholm, '11.07).

0240I003

Y.Hamazaki, Y.Morikawa, K.Nakamura, A.Yonekura, H.Nakagawa: Relationship between participation in asecondary screening for identifying frail elderly and new onset of need for care among the elderly in a rural town,
Japan, 2st Japan Korea joint Conference on Community Health Nursing, (Kobe, '11.07).

0240I004(Y.Nakamura), Y.Kiyohara, T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, S.Nagasawa, K.Miura,
H.Ueshima: Saturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality inJapan: NIPPON DATA90 1990-2005., European Society of Cardiology, (Paris, France, '11.08).

- 24 -

0240I005

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Le Ke: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

0240I006

S.Maruzeni, T.Kido, HD.Manh, R.Naganuma, S.Homma, XL.Sun, TT.Pham, M.Nishijo, H.Nakagawa, DD.Mhu,
LTH.Thom, NN.Hung, LK.Son: Impact of dioxin in breast milk on salivary steroid hormone of Vietnameseprimiparas, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

0240I007(T.Kido), R.Naganuma, XL.Sun, S.Maruzeni, HD.Manh, E.Koh, H.Suzuki, M.Nishijo, H.Nakagawa, S.Honma,
DD.Nhu, LTH.Thom, NN.Hung, LK.Son: Comparison of prostate specific antigen leveles in serum between
herbicides/dioxin-hot spot and non-sprayed in Vietnam, 31th International Symposium on Halogenated persistent
Organic Pollutants; Dioxin 2011, (Brussels, '11.08).

0240I008

K.Kitaoka, Y.Morikawa, H.Nakagawa: Burnout and stress coping styles among Japanese psychiatric nurses, 17th
International Network for Psychiatric Nursing Research Conference, (Oxford, '11.09).

0240I009(MN.Nguyen), E.Hori, S.Urakawa, TNA.Nguyen, T.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, HA.Tran, T.Ono,
H.Nishijo: Effects of maternal exposure to TCDD on parvalbumin-positive neurons in the limbic system of rat
offspring, The 6th International Conference of Neurons and Brain Diseases, (Toyama, '11.12).

- 25 -

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology, Drug Dependence

Senior Assistant Professor

WANG Lu elaine

Tumor pathology, Endocrine pathology, Forensic pathology

Assistant Professor

TAKEICHI Toshiaki

ER-stress,Drug Dependence

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001

T.Takeichi, M.Takarada-Iemata, K.Hashida, H.Sudo, T.Okuda, K.Kokame, T.Hatano, M.Takanashi, S.Funabe,
N.Hattori, O.Kitamura, Y.Kitao, O.Hori: The effect of Ndrg2 expression on astroglial activation, Neurochem. Int.,
59:21-27, 2011.

- 26 -

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

YASUDA Yukio

Professor

HORI Ariyuki

Senior Assistant Professor

FUKUNAGA
Toshiharu

Assistant Professor

KURODA Naohiro

Facultyundergraduate clinical teaching, graduate education of physicians,
medical education
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
laboratory medicine, standardization of blood gas analysis, pulmonary
function test.
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Others0260F001

A.Ishimaru, K.Yamashita, N.Tsuji, Y.Yasuda: An educational program of endotracheal suctioning using simulators
for physical therapists, J. Jpn. Assoc. Simul. Med. Educ., 4:37-40, 2011 (in Japanese) .

- 27 -

- 28 -

Clinical Medicine

0300Department of Cardiovascular Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Associate Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Associate Professor(Additional Post)

ASAJI Takayoshi

Heart failure

Senior Assistant Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Senior Assistant Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Assistant Professor

TAKEDA Kenji

Molecular Biology

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

KASENO Kenichi

Arrhythmia, Catheter ablation

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension

Assistant Professor

WAKASA Minoru

Heart failure

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Reviews
0300C001

Y.Kawai, R.Ishida, A.Motoyama, K.Kajinami: Place of pitavastatin in the statin armamentarium : promisingevidence for a role in diabetes mellitus, Drug Des. Devel. Ther., 5:283-297, 2011.

Others
0300F001

K.Kajinami, Y.Kawai: Beyond C-reactive Protein; new evidence for another inflammatory biomarker predicting
cardiovascular disease risk, Atherosclerosis, 214:39-40, 2011.

- 29 -

Presentations at Conference
International Conference (Presentations)
0300I001

H.Aoki, I.Matsunari, K.Kajinami: Do myocardial strain and strain rate reflect oxidative, ICNC10, (Amsterdam,'11.05).

0300I002

H.Aoki, K.Kajinami, I.Matsunari: 2D speckle tracking echocardiography and sympathetic neuronal function inpatients with left ventricular dysfunction, ICNC10, (Amsterdam, '11.05).

0300I003

R.Saito, Y.Kawai, M.Watanabe, A.Motoyama, R.Ishida, M.Kitayama, K.Kajinami: Atherogenic Lipid Profile andDevelopment of Multivessel Coronary Artery Disease in Women, 79th EAS CONGRESS, (Göteborg, '11.06).

0300I004

M.Wakasa, Y.Kawai, H.Aoki, A.Motoyama, R.Ishida, H.Akao, M.Kitayama, K.Kajinami: Association ofTransmyocardial Gradient of n-3 Polyunsaturated Fatty Acid with the Washout Rate of Tc-99m Sestamibi inPatients with Idiopathic Dilated Cardiomyopathy, ESC2011, (Paris, '11.08).

0300I005

M.Wakasa, Y.Kawai, M.Watanabe, H.Aoki, A.Motoyama, R.Ishida, N.Fujioka, H.Akao, M.Kitayama, K.Kajinami:
3-Methylglutaconic Aciduria (3MGA) in Adult Patients with Left Ventricular Systolic, ESC2011, (Paris, '11.08).

0300I006

H.Akao, E.Polisecki, K.Kajinami, S.Trompet, J.W.Jukema, Anton J.M. de Craen, Rudi G.J.Westendorp,
J.Shepherd, C.Packard, B.M.Buckley, E.J.Schaefer: Genetic Variation at SLCO1B1 Gene Locus and Low Density
Lipoprotein Cholesterol Lowering Response to Pravastatin in the Elderly, AHA2011, (Orlando, '11.11).

0300I007

H.Akao, E.Polisecki, K.Kajinami, S.Trompet, J.W.Jukema, Anton J.M. de Craen, Rudi G.J. Westendorp,
J.Shepherd, C.Packard, B.M.Buckley, E.J.Schaefer: KIF6, LPA, TAS2R50, and VAMP8 Genetic Variation, Low
Density Lipoprotein Cholesterol Lowering Response to Pravastatin and Heart Disease Risk Reduction in the
Elderly, AHA2011, (Orlando, '11.11).

- 30 -

0310

Department of Respirology (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Senior Assistant Professor

HUANG Jyongsu

lung physiology, sleep disordered breathing

Senior Assistant Professor

MIZUNO Shirolung cell and molecular biology，COPD

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Assistant Professor

TOBE Takeyasu

clinical respiratory medicine

Assistant Professor

TSUCHIHARA
Katsumaclinical respiratory medicine, lung cancer

Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

KOJIMA Koji

clinical respiratory medicine.

Assistant Professor

KOBAYASHI Makoto lung cell and molecular biology

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

YAMAYA Atsuyo

clinical respiratory medicine

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Reviews
0310C001(N.F.Voelker), J.G.Arroyo, S.Mizuno: COPD/emphysema: The vascular story, Pulm. Circ., 1:320-326, 2011.

0310C003

A.Yamaya, K.Osanai: Cytokines and proteases involved in pathogenesis of COPD, Japanese Journal of Clinical
Medicine, 69:1748-1753, 2011 (in Japanese) .

- 31 -

Case Reports
0310D001

M.Saito, S.Shinomiya, S.Kitadate, Y.Takahara, A. Yamaya, K.Kouji, Y.Fujimoto, T.Oikawa, K.Nakagawa,
K.Tsishihara, M.Iguchi, K.Osanai, H.Toga: A Case of rapidly progressing pulmonary mycosis caused by Aspergillus
niger developing fungus ball-like shadows, The Journal of the Japan Society for Respiratory Endoscopy, 33:33-37,
2011 (in Japanese) .

0310D002

K.Nakagawa, S.Kitadate, M.Saito, Y.Fujimoto, K.Kojima, T.Oikawa, K.Oikawa, M.Iguchi, J.Huang, K.Osanai,
H.Toga, K.Araida: Two cases of Birt-Hogg-Dube' syndrome in a family, Jpn. j. clin. Radiol., 56:133-137, 2011 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0310I001

S.Mizuno, J.R.Klinger, R.J.White, L.E.Fredenburgh, S.Adnot, K.A.Fagan, N.F.Voelkel, G.Choudhary, N.N.Bauer,
M.Oka, T.Lahm, I.R.Preston, R.A.Dweik: Pulmonary arterial remodeling induced by su5416 and allergic airway
inflammation, American Thoracic Society International Conference 2011, (Denver, '11.05)，Am. J. Respir. Crit.
Care Med., 183:A3406, 2011.

0310I002

S.Mizuno, J.R.Klinger, R.J.White, L.E.Fredenburgh, S.Adnot, K.A.Fagan, N.F.Voelkel, G.Choudhary, N.N.Bauer,
M.Oka, T.Lahm, I.R.Preston, R.A.Dweik: Incｒeased expression of miR34a and miR199a-5 in lung yissues from
COPD patinents, Amerivan Thoracic Society International Conference 2011, (Denver, '11.05)，Am. J. Respir. Crit.
Care Med., 183:A3524, 2011.

0310I003

S.Mizuno, J.R.Klinger, R.J.White, L.E.Fredenburgh, S.Adnot, K.A.Fagan, N.F.Voelkel, G.Choudhary, N.N.Bauer,
M.Oka, T.Lahm, I.R.Preston, R.A.Dweik: Effect of tumor suppressor ｐ53 on hypoxic pulmonary arterial
remodeling, American Thoracic Society International Conference 2011, (Denver, '11.05)，Am. J. Respir. Crit. Care
Med., 183:A3428, 2011.

0310I004

K.Osanai, M.Kobayashi, J.Higuchi, M.Zhou, J.Huang, H.Toga: Abeerant lung surgactant homeostasis in Rab38
small GTP ase-mutated rat lungs, American Thoracic Society International Conference 2011, (Denver, '11.05)，
Am. J. Respir. Crit. Care Med., 183:A5164, 2011.

0310I005

S.Mizuno: microRNA-34a and microRNA 199a-5p in COPD and their control of HIF-1alpha, European Respiratory
Society Annual Conference 2011, (Amsterdam, '11.09).

- 32 -

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Associate Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Faculty

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Senior Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Assistant Professor

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Assistant Professor

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease

Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Assistant Professor(Additional Post)

SAITO Takashi

Treament for metabolic syndrome

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis- 33 -

Publications
Originals
0320B001

M.Yamada, H.Shiroeda, R.Hayashi, H.Yano, K.Sato, M.Tsutsumi, T.Arisawa: Survival rates of early-stage HCVrelated liver cirrhosis patients without hepatocellular carcinoma are decreased by alcohol, J. Clin. Biochem. Nutr.,
48:167-169, 2011.

0320B002

T.Shibamoto, M.Tsutsumi, C.Omukai, Y.Kuda, W.Zhang, Y.Kurata: Ethanol predominantly constricts presinusoids of isolated perfused livers of rat, guinea pig and mouse, Alcohol Alcohol., 46:117-122, 2011.

0320B003(T.Shibata), T.Tahara, T.Arisawa, I.Hirata: Polymorphism of the salt sensitivity gene angiotensinogen and gastriccancer risk, Mol. Med. Report., 4:723-726, 2011.

0320B004(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Kamiya, T.Ishizuka,
Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata, T.Arisawa: Association between genetic polymorphisms related to
DNA repair or xenobiotic pathways and gastric premalignant conditions, Anticancer Res., 31:1459-65, 2011.

0320B005(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, H.Yamashita, D.Yoshioka, J.Yonemura, Y.Kmiya, T.Ishizuka,
H.Fujita, M.Nagasaka, H.Yamada, I.Hirata, T.Arisawa: Host genetic factors, related to inflammatory response,
influence the CpG island methylation status in colonic mucosa in ulcerative colitis, Anticancer Res., 31:933-938,
2011.

0320B006(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, H.Yamashita, D.Yoshioka, J.Yonemura, T.Ishizuka, I.Hirata,
T.Arisawa: Polymorphisms of DNA repair and xenobiotic genes predispose to CpG island methylation in nonneoplastic gastric mucosa, Helicobacter., 16:99-106, 2011.

0320B007(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Kamiya, T.Ishizuka,
I.Hirata, T.Arisawa: Effect of polymorphisms of IL-1β and TNF-α genes on CpG island hyper methylation(CIHM) in the nonneoplastic gastric mucosa, Mol. Carcinog., 31:705-10, 2011.

0320B008(M.Okubo), T.Tahara, T.Shibata, M.Nakamura, Y.Kamiya, D.Yoshioka, Y.Maeda, J.Yonemura, T.Ishizuka,
T.Arisawa, I.Hirata: Usefulness of magnifying narrow-band imaging endoscopy in the Helicobacter pylori-related
chronic gastritis, Digestion, 83:161-166, 2011.

0320B009(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda, N.Maruyama,
T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata, T.Arisawa: Effect of IL-1β and
TNF-α polymorphisms on the prognosis and survival of gastric cancer patients, Clin. Exp. Med., 11:211-217,
2011.

0320B010(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, H.Yamashita, D.Yoshioka, J.Yonemura, I.Hirata, T.Arisawa:
Association between polymorphisms in the XRCC1 and GST genes, and CpG island methylation status in colonicmucosa in ulcerative colitis, Virchows Arch., 458:205-211, 2011.

0320B011(M.Okubo), T.Tahara, T.Shibata, M.Nakamura, D.Yoshioka, Y.Maeda, J.Yonemura, T.Ishizuka, T.Arisawa,
I.Hirata: Changes in gastric mucosal patterns seen by magnifying NBI during H. pylori eradication, J.
Gastroenterol., 46:175-182, 2011.

0320B012(T.Tahara), T.Shibata, H.Yamashita, I.Hirata, T.Arisawa: Influence of MDR1 polymorphism on H. pylori-related
chronic gastritis, Dig. Dis. Sci., 56:103-108, 2011.

0320B013

M.Nakamura, T.Shibata, T.Tahara, D.Yoshioka, M.Okubo, J.Yonemura, T.Arisawa, I.Hirata: Usefulness oftransnasal endoscopy where endoscopic submucosal dissection is difficult, Gastric Cancer, 14:378-384, 2011.

0320B014(M.Okubo), T.Tahara, T.Shibata, H.Yamashita, M.Nakamura, D.Yoshioka, J.Yonemura, Y.Kamiya, T.Ishizuka,
Y.Nakagawa, M.Nagasaka, M.Iwata, H.Yamada, I.Hirata,, T.Arisawa: Association study of common genetic variants
in pre-microRNAs in patients with ulcerative colitis, J. Clin. Immunol., 31:69-73, 2011.

- 34 -

Others
0320F001

M.Yamada, H.Shiroeda, K.Sato, R.Hayashi, T.Nomura, M.Tsutsumi, T.Arisawa: Accelerated progression ofhepatocellular carcinoma with cytokeratin 19 expression during treatment with lamivudine for hepatitis B virusrelated liver cirrhosis, Scand. J. Gastroenterol., 45:249-251, 2011.

Presentations at Conference
International Conference (Presentations)
0320I001

M.Nakamura, T.Arisawa, T.Shibata, T.Tahara, M.Okubo, H.Shiroeda, T.Fukuyama, K.Ozaki, T.Otsuka, I.Hirata:
Comparison of cost-effectiveness of three treatments(Rabeprazole with rebamipide combination
therapy;lansoprazole with rebamipide combination therapy;raberazole monotherapy)for gastric ulcers post-ESD,
DDW2011（ASGE), (Chicago, '11.05).

0320I002

H.Shiroeda, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Saito, T.Fukuyama, N.Hayashi,
T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Shibata, T.Arisawa: Effects of -1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,on dap-kinase hypermenthylation in human gastricmucosa, DDW2011(AGA), (Chicago, '11.05).

0320I003

M.Nakamura, T.Arisawa, T.Shibata, T.Tahara, M.Okubo, H.Shiroeda, T.Fukuyama, K.Ozaki, T.Otsuka,
Y.Takakuwa, M.Kuroda, I.Hirata: Prospective study of collagenous colitis onset associated with long-term
administration of proton pump inhibitors, DDW2011(ASGE), (Chicago, '11.05).

0320I004

T.Fukuyama, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Otsuka, H.Yano, K.Ozaki, H.Shiroeda,
M.Tsuchishima, M.Tsutsumi, T.Shibata, T.Arisawa: The pre-microRNA 325,targeting Slc6a4 3'-Utr,gene
polymorphism is closely associated with the risk of functional dyspesia in Japan, DDW2011(AGA), (Chicago,'11.05).

0320I005

K.Ozaki, T.Tahara, M.Nakamura, T.Fukuyama, T.Otsuka, M.Okubo, T.Shibata, T.Arisawa: The-1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,affects the susceptibility to the gastric carcinogenesis
in Japan, DDW2011(AGA), (Chicago, '11.05).

0320I006

T.Arisawa, T.Tahara, M.Nakamura, T.Fukuyama, T.Otsuka, H.Shiroeda, M.Okubo, T.Shibata: The-449 C>Gpolymorphism of NFKVB1 gene,coding nuclear factor-kappa B,is associated with the susceptibility to the gastriccarcinogenesis in Japan, DDW2011(AGA), (Chicago, '11.05).

0320I007

J.George, T.Fukuyama, N.Hayashi, K.Ozaki, H.Shiroeda, T.Arisawa, M.Tsutsumi: Oxxasional alcohol intake
promotes nonalcoholic steatohepatitis in obese rats, ALPD2011, (Fukuoka, '11.10).

0320I008

J.George, J.D'Armiento, M.Tsutsumi: Human MMP-1 transgene protects expermentally induced hepatic fibrosis in
mice, AASLD2011, (San Francisco, '11.10).

0320I009

M.Tsuchishima, J.George, H.Shiroeda, T.Saito, T.Arisawa, M.Tsutsumi: Mechanism of the pathogenesis ofhepatocellular carcinoma during chronic administration of ethanol in mice, AASLD2011, (San Francisco, '11.11).

0320I010

Y.Kuginuki, H.Tonami, M.Tsutumi, T.Arisawa: Diffusion-weighted MR imaging with navigator -triggered
prospective acquisition correction at 3 T for the assessment of hepatic fibrosis, 97th Radiological Society of North
America, (Chicago, '11.11).

- 35 -

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor (Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Senior Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology

Assistant Professor

ADACHI Hiroki

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

KIMURA Shogo

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

- 36 -

Publications
Originals
0330B001(H.Sugiyama), H.Yokoyama, H.Sato, T.Saito, Y.Kohda, S.Nishi, K.Tsuruya, H.Kiyomoto, H.Iida, T.Sasaki,
M.Higuchi, M.Hattori, K.Oka, S.Kagami, M.Nagata, T.Kawamura, M.Honda, Y.Fukasawa, A.Fukatsu, K.Morozumi,
N.Yoshikawa, Y.Yuzawa, S.Matsuo, Y.Kiyohara, K.Joh, T.Taguchi, H.Makino: Japan renal biopsy registry: the firstnationwide, web-based, and prospective registry system of renal biopsies in Japan, Clin. Exp. Nephrol., 15:493503, 2011.

0330B002(K.Furuichi), Y.Hisada, M.Shimizu, T.Okumura, K.Kitagawa, K.Yoshimoto, Y.Iwata, H.Yokoyama, S.Kaneko,
T.Wada: Matrix metalloproteinase-2 (MMP-2) and membrane-type 1 MMP (MT1-MMP) affect the remodeling ofglomerulosclerosis in diabetic OLETF rats, Nephrol. Dial. Transplant., 26:3124-3131, 2011.

0330B003

Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi,
S.Miyazawa, S.Kuwabata: Ionic liquid enables simple and rapid sample preparation of human culturing cells forscanning electron microscope analysis, Microsc. Res. Tech., 74:415-420, 2011.

0330B004

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

0330B005

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi,
S.Kuwabata, S.Miyazawa: Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured
human cells by scanning electron microscopy., Microsc. Res. Tech., 74:1104-1108, 2011.

0330B007

H.Atsumi, I.Ishikawa, K.Morita, T.Nakazawa, H.Yokoyama: Computerized Decision Support (CDS) for Dosing ofIron and Erythropoiesis-stimulating Agents in Hemodialysis Patients, J. Kanazawa. Med. Univ., 36:119-123, 2011
(in Japanese) .

Reviews
0330C001

H.Yokoyama, H.Okuyama, H.Yamaya: Clinicopathological insights into lupus glomerulonephritis in Japanese andAsians, Clin. Exp. Nephrol., 15:321-330, 2011.

0330C003

J.Imura, H.Yokoyama: Renal complications in Sjogren syndrome, Clinic all-round ; Sogo rinsho., 60:1365-1370,
2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0330I001

S.Kimura, J.Imura, H.Atsumi, K.Fujimoto, Y.Chikazawa, M.Nakagawa, S.Hayama, H.Okuyama, H.Yamaya,
H.Yokoyama: A new insight into circulating fibrocytes and peritubular pericytes in renal allograft nephropathy,
XLVIII ERA-EDTA Congress, (Prague, '11.06).

0330I002

H.Yokoyama, A.Saito, I.Ishikawa: Cinacalcet loading test predicts the effect of long-term cinacalcet treatment inhemodialysis patients with secondary hyperparathyroidism, ASN Kidney Week 2011 Annual Meeting, (Philadelphia,'11.11).

- 37 -

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Senior Assistant Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Assistant Professor

ITO Hiroki

diabetes, thyroid diseases

Research Doctor

KANASAKI Megumi

diabetes

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001

X.Yang, S.Kume, Y.Tanaka, K.Isshiki, S.Araki, M.Chin-Kanasaki, T.Sugimoto, D.Koya, M.Haneda, T.Sugaya,
D.Li, P.Han, Y.Nishio, A.Kashiwagi, H.Maegawa, T.Uzu: GW501516, a PPARδ agonist, ameliorates
tubulointerstitial inflammation in proteinuric kidney disease via inhibition of TAK1-NFκB pathway in mice, PLoS
ONE, 6:e25271, 2011.

0340B002

M.Kitada, S.Kume, N.Imaizumi, D.Koya: Resveratrol improves oxidative stress and protects against diabetic
nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway, Diabetes,
60:634-643, 2011.

- 38 -

0340B003

H.Astumi, M.Kitada, K.Kanasaki, D.Koya: Reversal of redox-dependednt inhibition of diacylglycerol kinase by
antioxidants in mesangial cells exposed to high glucose, Mol. Med. Report., 4:923-927, 2011.

0340B004

M.Kitada, A.Takeda, T.Nagai, H.Ito, K.Kanasaki, D.Koya: Dietary restriction ameliorates diabetic nephropathy
through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty(fa/fa) rats: a model of type 2 diabetes, Exp. Diabetes Res., 2011/908185;1-11, 2011.

0340B005(T.Koyama), S.Kume, D.Koya, S.Araki, K.Isshiki, M.Chin-Kanasaki, T.Sugimoto, M.Haneda, T.Sugaya,
A.Kashiwagi, H.Maegawa, T.Uzu: SIRT3 attenuates palmitate-induced ROS production and inflammation inproximal tubular cells., Free Radic. Biol. Med., 51:1258-67, 2011.

0340B006(T.Uzu), H.Yokoyama, H.Ito, D.Koya, A.Nakagawa, M.Nishizawa, H.Maegawa, Y.Yokomaku, S.Araki, A.Abiko,
M.Haneda: Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol,
Clin. Exp. Nephrol., 15:58-63, 2011.

0340B007(S.Maeda), D.Koya, S.Araki, T.Babazono, T.Umezono, M.Toyoda, K.Kawai, M.Imanishi, T.Uzu, D.Suzuki,
H.Maegawa, A.Kashiwagi, Y.Iwamoto, Y.Nakamura: Association between single nucleotide polymorphisms withingenes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes, Clin. Exp.
Nephrol., 15:381-390, 2011.

Reviews
0340C001

M.Kanasaki, T.Nagai, M.Kitada, D.Koya, K.Kanasaki: Elevation of the antifibrotic peptide N-acetyl-serylaspartyl-lysyl-proline: a blood pressure-independent beneficial effect of angiotensin I-converting enzyme
inhibitors, Fibrogenesis Tissue Repair, 4:25;1-12, 2011.

0340C002

F.Liang, R.Chen, A.Nakagawa, M.Nishizawa, S.Tsuda, H.Wang, D.Koya: Low-Frequency Electroacupuncture
Improves Insulin Sensitivity in Obese Diabetic Mice through Activation of SIRT1/PGC-1α in Skeletal Muscle,
Evid Based Complement Alternat Med, 2011/197636;1-9, 2011.

0340C003

K.Kanasaki, D.Koya: Biology of obesity: lessons from animal models of obesity, J. Biomed. Biotechnol.,
2011/735297;1-11, 2011.

0340C004

D.Koya, S.Araki, M.Haneda: Therapeutic management of diabetic kidney disease, JDI., 2:248-254, 2011.

0340C007

A.Nakagawa, M.Nishizawa, D.Koya: Food intake－suppressing action of incretin and anti－obesity therapy,
Japanese Journal of Clinical Medicine, 69:826-830, 2011 (in Japanese) .

0340C011

A.Nakagawa, M.Nishizawa, D.Koya: Food intake-suppressing action of incretin and anti-obesity therapy, Japanese
Journal of Clinical Medicine, 69:826-830, 2011 (in Japanese) .

Case Reports
0340D001

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, A.Nakagawa, N.Kurose: Composite pheochromocytoma withganglioneuroma in the adrenal gland: A case report, J. Kanazawa. Med. Univ., 36:83-85, 2011 (in Japanese) .

0340D002

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Astumi, H.Minato, K.Sato:
Adrenal myelolipoma: A report of two cases, J. Kanazawa. Med. Univ., 36:86-89, 2011 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0340H001

K.Kanasaki: Role of 2-ME, PlGF and Stox1 Transcriptional Factor in Preeclampsia, World Congress Of
Nephrology 2011, (Vancouver, '11.04).

0340H002

K.Kanasaki: Natural History of Diabetic Nephropathy in Japanese, The 3rd Annual Scientific Meeting of the Asian
Association for the Study of Diabetest, (Beijing, '11).

- 39 -

International Conference (Presentations)
0340I001

M.Kanasaki, K.Kanasaki, D.Koya: Catechol-o-Methyltransferase Deficiency Is Associated with Abnormal Adiposity
and Glucose Intolerance: Implication for a New Mechanism of Metabolic Syndrome, American Diabetes Association- 71th Scientific Sessions, (San Diego, '11.06).

0340I002

A.Watanabe, K.Kanasaki, A.Nakagawa, M.Nishizawa, M.Kanasaki, M.Kitada, K.Konishi, S.Tsuda, K.Furuya,
D.Koya: Diverse homeostasis in micronutrients and homocysteine in type 2 diabetic patients, American Diabetes
Association - 71th Scientific Sessions, (San Diego, '11.06).

0340I003

D.Koya, M.Kitada, K.Kanasaki: Dietary restriction-induced Sirt1 activation protects obesity related metabolic
alteration in overweight male, 10th Japan-Korea Diabetic Nephropathy Seminer, (Korea, '11.09)，10th JapanKorea Diabetic Nephropathy Seminer Program・Abstracts, 11, 2011.

0340I004

K.Kanasaki, M.Kanasaki, D.Koya: Catechol-o-methyltrase deficiency is liked to metabolic syndrome, 10th JapanKorea Diabetic Nephropathy Seminer, (Korea, '11.09)，10th Japan-Korea Diabetic Nephropathy Seminer
Program・Abstracts, 17, 2011.

0340I005

K.Kanasaki: Catechol-o-methyltransferase deficiency is linked to metabolic syndrome, The 10th Japan-Korea
Diabetic Nephropathy Seminar, (Korea, '11.09).

0340I006

K.Kanasaki: Identification of Stox1 Transcriptional Factor as a Spcific Repressor of Placental Renin and Its
Deficiency Leads to Vascular Defects and Gestational Hypertension, American Society of Nephrology 44th Annual
Meeting, (Philadelphia, '11.11).

- 40 -

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Associate Professor

TANAKA Masao

Rheumatology, Immunology

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Assistant Professor

SAWAKI Toshioki

Hematology and Immunology

Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

MIKI Miyuki

Hematology and Immunology

Assistant Professor

IWAO Haruka

Hematology and Immunology

Assistant Professor

NAKAJIMA Akio

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A)Studies of immunological abnormalities and pathophysiology of autoimmune diseases:
1) Effects of chemokines on vascular injury and Th1 response during chronic inflammation.
2) Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases.
3) Analysis of immunological disorder in sphingomyelin knockout mice.
4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis.
5) Detection of stem cells in salivary glands and its implication for regenerative medicine.
B)Studies of hematological malignancies and development of anti-cancer drugs:
1) Analysis of EB-virus proteins and their roles in lymphoproliferative disorders.
2) Molecular biological analysis of drug resistance.
3) Roles of sphingomyelin on apoptosis.

- 41 -

Publications
Originals
0350B001(T.Daniels), D.Cox, C.Shiboski, M.Schiodt, A.Wu, H.Lanfranchi, H.Umehara, Y.Zhao, S.Challacombe, M.Lam,
Y.Souza, J.Schiodt, H.Holm, P.Bisio, M.Gandolfo, T.Sawaki, M.Li, W.Zhang, B.Varghese-Jacob, P.Ibsen,
A.Keszler, N.Kurose, T.Nojima, E.Odell, L.Criswell, R.Jordan, J.Greenspan: Associations between salivary glandhistopathologic diagnoses and phenotypic features of Sjögren's syndrome among 1,726 registry participants,
Arthritis Rheum, 63:2021-2030, 2011.

0350B002

T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara: Efficacy and safety of bortezomib plus dexamethasone therapy forrefractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence ofgastrointestinal adverse events, Anticancer Res., 31:2297-2302, 2011.

0350B003(M.Kawano), T.Saeki, H.Nakashima, S.Nishi, Y.Yamaguchi, S.Hisano, N.Yamanaka, D.Inoue, M.Yamamoto,
H.Takahashi, H.Nomura, T.Taguchi, H.Umehara, H.Makino, T.Saito: Proposal for diagnostic criteria for IgG4related kidney disease, Clin. Exp. Nephrol., 15:615-626, 2011.

0350B004(A.Shakor), M.Taniguchi, K.Kitatani, M.Hashimoto, S.Asano, A.Hayashi, K.Nomura, J.Bielawski, A.Bielawska,
K.Watanabe, T.Kobayashi, Y.Igarashi, H.Umehara, H.Takeya, T.Okazaki: Sphingomyelin synthase 1-generated
sphingomyelin plays an important role in transferrin trafficking and cell proliferation, J. Biol. Chem., 286:3605336062, 2011.

0350B005

Y.Masaki, M.Miki, Y.Sun, T.Nakamura, H.Iwao, A.Nakajima, N.Kurose, T.Sakai, Z.Jin, T.Sawaki, T.Kawanami,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: High-dose methotrexate with R-CHOP therapy for thetreatment of patients with primary central nervous system lymphoma, Int. J. Hematol., 93:720-726, 2011.

0350B006(M.Yano), K.Watanabe, T.Yamamoto, K.Ikeda, T.Senokuchi, M.Lu, T.Kadomatsu, H.Tsukano, M.Ikawa, M.Okabe,
S.Yamaoka, T.Okazaki, H.Umehara, T.Gotoh, W.Song, K.Node, R.Taguchi, K.Yamagata, Y.Oike: Mitochondrial
dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice,
J. Biol. Chem., 286:3992-4002, 2011.

0350B007(K.Fujiwara), K.Kitatani, K.Fukushima, H.Yazama, H.Umehara, M.Kikuchi, Y.Igarashi, H.Kitano, T.Okazaki:
Inhibitory effecs of dietary glucosylceramides on squamous cell carcinoma of the head and neck in NOD/SCID
mice, Int. J. Clin. Oncol., 16:133-140, 2011.

0350B008(K.Ghoreschi), M.I.Jesson, X.Li, J.L.Lee, S.Ghosh, J.W.Alsup, J.D.Warner, M.Tanaka, S.M.Steward-Tharp,
M.Gadina, C.J.Thomas, J.C.Minnerly, C.E.Storer, , , , Head RD,, Z.A.Radi, M.E.Dowty, R.D.Head, D.M.Meyer,
N.Kishore, J.J.O'Shea: Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550), J.
Immunol., 186:4234-4243, 2011.

Reviews
0350C001

Y.Masaki, H.Iwao, A.Nakajima, M.Miki, S.Sugai, H.Umehara: IgG4-related disease (IgG4+MOLPS)-diagnostic
criteria and diagnostic problems, Curr. Immunol. Rev., 7:172-177, 2011.

0350C002

Y.Masaki, N.Kurose, H.Umehara: IgG4-related disease: a novel lymphoproliferative disorder discovered andestablished in Japan in the 21st century, J. Clin. Exp. Hematop., 51:13-20, 2011.

0350C004

Y.Masaki, M.Miki, T.Sakai, T.Sawaki, T.Fukushima, H.Umehara: Intravascular large B-cell lymphoma: an
important cause of fever of unknown origin, Brain and nerve., 63:435-441, 2011 (in Japanese) .

0350C005

H.Umehara: Functions of IgG4, and pathogenesis of IgG4-related disease (IgG4RD), Journal of Medical
Technology, 55:731-735, 2011 (in Japanese) .

0350C006

Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, H.Umehara: IgG4-related Mikulicz's disease and Sjögren's syndrome,
Journal of Medical Technology, 55:763-769, 2011 (in Japanese) .

- 42 -

Case Reports
0350D001

T.Fukushima, H.Kawabata, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, Y.Hirose, H.Umehara: Iron chelation therapy with deferasirox induced complete remission in a patientwith chemotherapy-resistant acute monocytic leukemia, Anticancer Res., 31:1741-1744, 2011.

0350D002(F.Kim), K.Yamada, D.Inoue, K.Nakajima, I.Mizushima, Y.Kakuchi, H.Fujii, K.Narumi, M.Matsumura, H.Umehara,
M.Yamagishi, M.Kawano: IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without
hypocomplementemia, Intern. Med., 50:1239-1244, 2011.

0350D003(Y.Kakuchi), K.Yamada, Y.Suzuki, N.Ito, K.Yagi, M.Matsumura, M.Yamagishi, H.Umehara, Y.Zen, M.Hasegawa,
K.Takehara, M.Kawano: IgG4-related skin lesions in a patient with IgG4-related chronic sclerosing dacryoadenitis
and sialoadenitis, , 50:1465-1469, 2011.

0350D004

M.Kaito, H.Iwao, E.Kinoshita, H.Funaki, O.Tachibana, M.Matsui: A case of Castleman disease with statusepileptics originating from focal cortical dysplasia, Clinical Neurology, 51:487-492, 2011 (in Japanese) .

Others
0350F001(K.Miura), H.Takasaki, H.Tsujimura, M.Kanno, Y.Maeda, N.Tomita, K.Takai, Y.Masaki, J.Takizawa, H.Mori,
Y.Terasaki, T.Yoshida, J.Takeuchi, S.Motomura: Does more intensive therapy have effects on mantle cell
lymphoma? A clinical experience from the lymphoma treatment study group in Japan, Int. J. Hematol., 93:684-686,
2011.

0350F002

T.Fukushima, T.Nakamura, H.Iwao, H.Umehara: Rapid response of plasmacytomas to lenalidomide plus low-dose
dexamethasone therapy in a patient with relapsed multiple myeloma, Am. J. Hematol., 86:893, 2011.

Presentations at Conference
International Conference (Presentations)
0350I001

Y.Masaki, N.Kurose, S.Sugai, H.Umehara: Analysis of serum IgG4 cut-off value to distinguish Sjögren's syndromefrom IgG4-related disease, 11th International symposium on Sjögren's syndrome, (Athens, '11.09).

0350I002(M.Kawano), T.Saeki, H.Nakashima, S.Nishi, Y.Yamaguchi, S.Hisano, N.Yamanaka, D.Inoue, M.Yamamoto,
H.Takahashi, H.Nomura, T.Taguchi, H.Umehara, H.Makino, T.Saito: Proposal for diagnostic criteria for IgG4related kidney disease, The First International Conference On IgG4-Related Disease (IgG4-RD), (Boston, '11.10).

0350I003(I.Mizushima), M.Kawano, K.Yamada, H.Fujii, D.Inoue, H.Umehara, M.Yamagishi, Y.Yamaguchi, M.Nagata,
M.Matsumura: Clinicopathological changes associated with corticosteroid therapy in IgG4-related tubulointerstitialnephriti, The First International Conference On IgG4-Related Disease (IgG4-RD), (Boston, '11.10).

- 43 -

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology

Senior Assistant Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Assistant Professor

NAKATA Michiyo

Clinical neurology

Assistant Professor

MINATO Naomi

Clinical neurology

Research Associate

INADA Hiroyuki

Applied animal science

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001

N.Hashiba, S.Nagayama, S.Arara, H.Inada, Y.Sonobe, A.Suzumura, M.Matsui: Phenytoin at optimum doses
ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells, J.
Neuroimmunol., 223:112-119, 2011.

0360B002(K.Arima), A.Kinoshita, H.Mishima, N.Kanazawa, T.Kaneko, T.Mizushima, K.Ichinose, H.Nakamura, A.Tsujino,
A.Kawakami, M.Matsunaka, S.Kasagi, S.Kawano, S.Kumagai, K.Ohmura, T.Mimori, M.Hirano, S.Ueno, K.Tanaka,
M.Tanaka, I.Toyoshima, H.Sugino, A.Yamakawa, K.Tanaka, N.Niikawa, F.Furukawa, S.Murata, K.Eguchi, H.Ida,
K.Yoshiura: Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the
autoinflammatory disorder, Nakajo-Nishimura syndrome, Proc. Natl. Acad. Sci. U.S.A., 108:14914-14919, 2011.

0360B003(A.Nagaishi), M.Takagi, A.Umemura, M.Tanaka, Y.Kitagawa, M.Matsui, M.Nishizawa, K.Sakimura, K.Tanaka:
Clinical features of neuromyelitis optica in a large Japanese cohort: comparison between phenotypes, J. Neurol.
Neurosurg. Psychiatry, 82:1360-1364, 2011.

0360B004(M,Tanaka), M.Kousaka, M.Tahara, M.Matsui, K.Tanaka: Causes of death in Japanese patients with multiple
sclerosis and neuromyelitis optica, Neurological Medicine, 74:604-606, 2011 (in Japanese) .

Case Reports
0360D001(K.Tojo), K.Nitta, W.Ishii, Y.Sekijima, H.Morita, Y.Takahashi, K.Tanaka, S.Ikeda: A young man with Anti-NMDAR
encephalitis following Guillain Barré syndrome, Case Rep. Neurol., 3:7-13, 2011.

- 44 -

0360D002(T.Serikawa), T.Shimohata, M.Akashi, A.Yokoseki, M.Tsuchiya, A.Hasegawa, K.Haino, R.Koike, K.Takakuwa,
K.Tanaka, K.Tanaka, M.Nishizawa: Successful twin pregnancy in a patient with parkin-associated autosomal
recessive juvenile parkinsonism, BMC Neurol., 11:72;1-3, 2011.

0360D003

S.Nagayama, Y.Gondo, M.Kaito, M.Nakanishi, M.Matsui: A case of left thalamic infarction causing dysgeusia in theright half of the tongue: Follw-up examinations using electrogustometry, Japanese Journal of Stroke., 33:370-373,
2011 (in Japanese) .

0360D004

M.Kaito, H.Iwao, E.Kinoshita, H.Funaki, O.Tachibana, M.Matsui: A case of Castleman disease with statusepileptics originating from focal cortical dysplasia, Clinical Neurology, 51:487-492, 2011 (in Japanese) .

0360D005(M.Kitada), H.Suzuki, J.Ichihashi, Y.Mitsui, K.Tanaka, S.Kusunoki: Dramatic improvement in two cases of antiNMDA receptor encephalitis after immunomodulating therapy, Clinical Neurology, 51:683-687, 2011 (inJapanese) .

0360D006(H.Nakano), R.Motoyama, K.Tanaka, M.Tanaka: A case of neuromyelitis optica with varicella zoster virus
meningitis during mitoxantrone treatment, Clinical Neurology, 51:703-705, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0360I001

K.Tanaka, M.Nakata, Q.Zhang, R.Sun, K.Sakimura, M.Makoto, N.Kato: Functional effects of the CSF from antiNMDA receptor encephalitis patient on NMDAR-mediated synaptic transmission, 63th American Academy of
Neurology Annual Meeting, (Honolulu, '11.04).

- 45 -

0560

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Associate Professor

NAKAJIMA Hideo

Medical Oncology, Immunology, Molecular Biology

Senior Assistant Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

NAKAYA Naoki

Medical Oncology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0560B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

0560B002

T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara: Efficacy and safety of bortezomib plus dexamethasone therapy forrefractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence ofgastrointestinal adverse events, Anticancer Res., 31:2297-2302, 2011.

0560B003

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

0560B004

T.Shimasaki, K.Miyazawa, M.Moriyama, T.Tanaka, I.Sato, N.Nakaya, H.Nakajima, A.Kubo, K.Suzuki, Y.Motoo:
Combination chemotherapy of docetaxel and uft against hormone refractory prostate cancer, Acta Urol. Jpn.,
57:163-166, 2011 (in Japanese) .

Reviews
0560C001

Y.Motoo, T.Seki, K.Tsutani: Traditional Japanese medicine, Kampo: Its history and current status, Chin. J. Integr.
Med., 17:85-87, 2011.

- 46 -

0560C002

Y.Motoo, T.Shimasaki, Y.Ishigaki, H.Nakajima, K.Kawakami, T.Minamoto: Metabolic disorder, inflammation, andderegulated molecular pathways converging in pancreatic cancer development: Implications for new therapeuticstrategies, Cancers (Basel)., 3:446-460, 2011.

Case Reports
0560D002

N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo: A Case of primary cardiac
angiosarcoma associated with cardiac tamponade, Cancer & chemotherapy., 38:1353-1355, 2011 (in Japanese) .

Others0560F009

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

0560F010

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

0560F011

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
0560H001

Y.Motoo: Chemotherapy for pancreatic cancer: molecular analysis and clinical application, Asian Oncology Summit
2011, (Hong Kong SAR, '11.04).

0560H002(K.Ogawa), M.Ogawa, Y.Motoo: Kampo Therapy for Cancer Care: Significance as Supportive Measure, 1stInternational Symposium for Japanese Kanpo Medicine, (Munich, '11.11).

International Conference (Presentations)
0560I001

Y.Motoo: Proposal of comparative analysis of herbal medicines among CJK and alignment of the ICTM Herbal
Interventions with other international initiatives, WHO ICTM TAG Classification of Interventions, (Hong Kong
SAR, China, '11.04).

0560I002

Y.Motoo: Japanese viewpoint of ISO/TC249, The Second Plenary Meeting of ISO/TC249, (The Hague, theNetherlands, '11.05).

0560I003

Y.Motoo: Evaluation of Japanese clinical practice guidelines based on Kampo descriptions, Guidelines International
Network Conference 2011, (Seoul, Korea, '11.08).

0560I004

Y.Motoo: Pancreatic cancer: experimental sensitization to gemcitabine and patient care with traditional Japanese
medicine, International Conference on Cancer Prevention, (Seoul, Korea, '11.08).

0560I005

H.Nakajima, T.Minamoto, Y.Motoo: HITS(FAM107B): Novel heat-shock induced protein as a maker for cancer
progression and diagnosis, 16th World Congress on Advances in Oncology and 14th International Symposium on
Molecular Medicine, (Rhodes Island, Greece, '11.10).

0560I006

Y.Motoo, I.Arai, K.Tsutani: Evidence Reports on Kampo Treatment (EKAT), The First International Symposiumfor Japanese Kampo Medicine, (Munich, Germany, '11.11).

0560I007

N.Nakaya, Y.Ishigaki, Q.Bian, S.Ma, T.Shimasaki, H.Nakajima, Y.Motoo: Molecular mechanisms of TP531NP1 in
the gemcitabine sensitivity, The International Pancreatic Research Forum 2011, (Osaka, '11.11).

- 47 -

0560I008

Y.Motoo, I.Arai, T.Hakamatsuka: Japanese viewpoint on ICTM Interventions, Informal Consultation on
Interventions Modeling, (Geneva, Switzerland, '11.12).

- 48 -

0565

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

BABA Hisashi

Clinical Infectious Diseases, Infection Control and Prevention,
Clinical Microbiology

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0565B001(Y.Matsumura), Y.Shindo, Y.Iinuma, M.Yamamoto, M.Shirano, A.Matsushima, M.Nagao, Y.Ito, S.Takakura,
Y.Hasegawa, S.Ichiyama: Clinical characteristics of pneumocystis pneumonia in non-HIV patients and prognostic
factors including microbiological genotypes, BMC Infect. Dis., 11:76,1-9, 2011.

0565B002(K.Maekawa), Y.Ito, T.Hirai, T.Kubo, S.Imai, S.Tatsumi, K.Fujita, S.Takakura, A.Niimi, Y.Iinuma, S.Ichiyama,
K.Togashi, M.Mishima: Environmental risk factors for pulmonary Mycobacterium avium-intracellulare complex
disease, Chest., 140:723-729, 2011.

0565B003(S.Imai), Y.Ito, T.Ishida, T.Hirai, I.Ito, K.Yoshimura, K.Maekawa, S.Takakura, A.Niimi, Y.Iinuma, S.Ichiyama,
M.Mishima, the Kansai Community Acquired Pneumococcal Pneumonia Study Group: Distribution and clonalrelationship of cell surface virulence genes among streptococcus pneumoniae isolates in Japan, Clin. Microbiol.
Infect., 17:1409-1414, 2011.

0565B004(M.Nagao), Y.Iinuma, J.Igawa, T.Saito, K.Yamashita, T.Kondo, A.Matsushima, S.Takakura, A.Takaori-Kondo,
S.Ichiyama: Control of an outbreak of carbapenem-resistant Pseudomonas aeruginosa in a haemato-oncology unit,
J. Hosp. Infect., 79:49-53, 2011.

Short Communications
0565E001(M.Suzuki), K.Yamada, M.Nagao, E.Aoki, M.Matsumoto, T.Hirayama, H.Yamamoto, R.Hiramatsu, S.Ichiyama,
Y.Iinuma: Antimicrobial ointments and methicillin-resistant Staphylococcus aureus USA300, Emerging Infect. Dis.,
17:1917-1920, 2011.

- 49 -

0630

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

YAMAKAWA Junichi

General medicine,Kampo medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

J.Moriya, R.Chen, J.Yamakawa, K.Sasaki, Y.Ishigaki, T.Takahashi: Resveratrol improves hippocampal atrophy inchronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells, Arch. Oral Biol., 34:354359, 2011.

- 50 -

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor (Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Professor (Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis

Senior Assistant Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Senior Assistant Professor(Additional Post)

NOMURA Koji

Geriatrics, Circulation

Assistant Professor

SATO Kazuto

Geriatrics, Circulation

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

ATSUMI Mikiko

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Research Doctor

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis

Research Doctor

TAKATA MeikoGeriatrics

Faculty

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

L.Zeng, R.Chen, K.Ishigami, M.Atsumi, Y.Koizumi, K.Sato, O.Iritani, M.Okuro, S.Morimoto: Association between
human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility,
Hypertens. Res., 34:474-478, 2011.

- 51 -

0370B002(M.Shiraki), T.Kuroda, N.Miyakawa, N.Fujinawa, K.Tanzawa, A.Ishizuka, S.Tanaka, Y.Tanaka, T.Hosoi, E.Itoi,
S.Morimoto, A.Itabashi, T.Sugimoto, T.Yamashita, I.Gorai, S.Mori, H.Kishimoto, H.Mizunuma, N.Endo,
Y.Nishizawa, K.Takaoka, Y.Ohashi, H.Ohta, M.Fukunaga, T.Nakamura, M.Orimo: Design of a pragmatic approachto evaluate the effectiveness of concurrent treatment for the prevention of osteoporotic fractures: rationale, aims
and organization of a Japanese Osteoporosis Intervention Trial (JOINT) initiated by the Research Group of
Adequate Treatment of Osteoporosis (A-TOP), J. Bone Miner. Metab., 29:37-43, 2011.

Reviews
0370C001(T.Takahashi), K.Iijima, M.Kuzuya, H.Hattori, K.Yokono, S.Morimoto: Guidelines for non-medical care providers
to manage the first steps of emergency triage of elderly evacuees, Geriatr. Gerontol. Int., 11:383-394, 2011.

0370C004

S.Morimoto: Detection and management of illnesses in elderly evacuees by medical teams, Journal of the Japan
Diabetes Society., 54:715-718, 2011 (in Japanese) .

0370C006

M.Okuro, S.Morimoto: Forntiers in vitamin D ; Basic research and clinical application. Activated vitamin D inpsoriasis, Clin. Calcium, 21:1621-1626, 2011 (in Japanese) .

Others
0370F001

S.Morimoto, K.Iijima, M.Kuzuya, H.Hattori, K.Yokono, T.Takahashi: Guidelines for non-medical care providers todetect illnesses in elderly evacuees after the 2011 earthquake off the Pacific coast of Tohoku, J. Am. Geriatr. Soc.,
59:2189-2191, 2011.

0370F002(K.Iijima), K.Shimokado, T.Takahashi, S.Morimoto, Y.Ouchi: Actions of the Japan Geriatric Society in response to
the 2011 off the Pacific Coast of Tohoku Earthquake: first report, Geriatr. Gerontol. Int., 11:525-526, 2011.

- 52 -

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITO Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

KOBAYASHI Azusa

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Assistant Professor

HIRAMATSU Masayuki Pediatric allergy, Pediatric immunology

Assistant Professor

HORISAWA Torou

Pediatric hematology, Pediatric oncology

Assistant Professor

KITAOKA Chika

Pediatric cardiology

Assistant Professor

YAMASHITA Yoko

Pediatric allergy, Pediatric immunology

Research Doctor

KITO Toshiyuki

Pediatric allergy, Pediatric immunology

Research Doctor

YAMAMOTO Akiko

Child neurology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism
Neonatology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(M.Taguchi), F.Ichida, K.Hirono, T.Miyawaki, N.Yoshimura, T.Nakamura, C.Akita, T.Nakayama, T.Saji, Y.Kato,
I.Horiuchi, Y.Hashimoto: Pharmacokinetics of bosentan in routinely treated Japanese pediatric patients withpulmonary arterial hypertension, Drug Metab. Pharmacokinet., 26:280-287, 2011.

0380B002(T.Taga), Y.Shimomura, Y.Horikoshi, A.Ogawa, M.Itoh, M.Okada, J.Ueyama, T.Higa, A.Watanabe, H.Kanegane,
A.Iwai, Y.Saikawa, K.Kogawa, J.Yamanaka, M.Tsurusawa: Continuous and high-dose cytarabine combined
chemotherapy in children with down syndrome and acute myeloid leukemia: Report from the Japanese children's
cancer and leukemia study group (JCCLSG) AML 9805 down study, Pediatr Blood Cancer, 57:36-40, 2011.

- 53 -

Case Reports
0380D001(H.Takamatsu), H.Yagasaki, Y.Takahashi, A.Hama, Y.Saikawa, A.Yachie, S.Koizumi, S.Kojima, S.Nakano: Aplastic
anemia successfully treated with rituximab: the possible role of aplastic anemia-associated autoantibodies as amarker for response, Eur. J. Haematol., 86:541-545, 2011.

0380D002(K.Nagasaki), M.Ito, O.Naoki, M.Kubota, T.Kikuchi, M.Uchiyama: Two cases of 22q11.2 deletion syndrome withanorectal anomalies and growth retardation, J. Pediatr. Endocrinol. Metab., 24:585-586, 2011.

0380D003(K.Ohta), T.Yokoyama, M.Shimizu, K.Mizuno, S.Sakazume, T.Fujiki, Y.Saikawa, A.Yachie: Diffusion-weighted MRIof exercise-induced acute renal failure (ALPE), Pediatr. Nephrol., 26:1321-1324, 2011.

- 54 -

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Professor

KUBOTA Takashi

Schizophrenia, Psychopharmacology, Epilepsy

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Senior Assistant Professor

MONKAWA Akikazu

Brain imaging, Schizophrenia

Senior Assistant Professor

MONKAWA Tomomi

Psychopharmacology, Neuropsychology

Assistant Professor

KOIZUMI Hazuki

Clinical Psychology, Cognitive-behaviora ltherapy

Assistant Professor

KOSEKI Yojyu

Brain imaging

Assistant Professor

SHOU Masaya

Psychopharmacology

Assistant Professor

MASUDA Shinji

Schizophrenia

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Books
0390A001(T. Sumiyoshi), Y.Higuchi, T.Ito, Y.Kawasaki: Electrophysiological Imaging Evaluation of Schizophrenia andTreatment Response, Handbook of Schizophrenia Spectrum Disorders VolumeⅢ, 135-148, Springer, Tokyo, 2011.

Presentations at Conference
International Conference (Presentations)
0390I001(M. Suzuki), Y,Takayanagi, Y.Kawasaki, T.Takahashi, K.Nakamura: Structural MRI-based Classification ofIndividual Patients with Schizophrenia:Possible Contributions to Clinical Diagnosis, The 2nd Asian Congress on
Schizophrenia Research, (Seoul, '11.02).

- 55 -

0390I002

Y.Kawasaki: longitudinal voxel-based morphometry to evaluateprogressive gray mater changes in first-episodeschizophrenia, 19th European Congress of Psychiatry, (WIen, '11.03).

0390I003

M.Shou, T.Kubota, T.Monkawa, Y.Koseki, K.Watanabe, Y.Kawasaki: Effects of risperidone and blonanserin on
excitatory synaptic transmission,and dopamine and serotonin leves in the hippocampus in rabbits, 10th World
Congress of Biological Psychiatry, (Puraha, '11.06).

0390I004

Y.Kawasaki: Diminished limbic activation associated with face perception in patients with schizophrenia, 24th
ECNP Congress, (Paris, '11.09).

0390I005

Y.Kawasaki: Reduced white matter fractional anisotropy and clinical symptoms schizophrenia:a voxel-based
diffusion tensor imaging study, ISNIP2011, (heidlberg, '11.09).

0390I006

H.Koizumi, K.Watanabe, K.Hirata, M.Takahashi, Y.Kawasaki: Functional MRI study of neuronal activation during
generation of ideas in patients with OCD before and after cognitive-behavioral therapy, 41th EABCT Annual
Congress, (Reykjavik, Iceland, '11.09).

- 56 -

0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

WATANABE Naoto

Nuclear Medicine

Associate Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

Associate Professor

TANIGUCHI Mitsuru

Cardiac Nuclear Medicine

Senior Assistant Professor(Additional Post)

KUGINUKI Yasuaki

Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Diagnostic Imaging

Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

KITADATE Masataka Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

TSUNEYAMA Nao

Diagnostic Imaging

Assistant Professor(Additional Post)OTA Kiyotaka

Radiation Therapy

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

K.Usuda, Xi.Zhao, M.Sagawa, M.Matoba, Y.Kuginuki, M.Taniguchi, Y.Ueda, T.Sakuma: Diffusion-weighted imaging
is superior to positron emission tomography in the detection and nodal assessment of lung cancers, Ann. Thorac.
Surg., 91:1689-1695, 2011.

0400B002(J.F.Guo), K.Higashi, Y.Ueda, Y.Ishigaki, T.Sakuma, M.Oguchi, T.Takegami, Y.Ohta, L.Zhang, K.Xu, H.Nishida,
H.Tonami: VEGF-A and its isoform VEGF121 mRNA expression measured by quantitative real-time RT-PCR:
correlation with F-18 FDG uptake and aggressiveness of lung adenocarcinoma: preliminary study, Ann. Nucl.
Med., 25:29-36, 2011.

- 57 -

0400B003

M.Matoba, I.Toyota, Y.Kuginuki, H.Tonami, T.Miyazawa, Y.Shimode, H.Tsuji, T.Miwa: Efficacy of diffusionweighted MR imaging and PET/CT for predicting and detecting early response to chemoradiation therapy
squamous cell carcinoma in the head and neck, J. J. M. R. M., 31:115-123, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0400I001

K.Usuda, M.Sagawa, X.Zhao, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, T.Sakuma: Comparative studyof diffusion-weighted magnetic resonance imaging and PET-CT to detect non-small cell lung cancer and its nodal
involvement, 23rd European Congress of Radiology 2011, (Vienna, '11.03).

0400I002

Y.Kuginuki, H.Tonami, M.Tsutumi, T.Arisawa: Diffusion-weighted MR imaging with navigator -triggered
prospective acquisition correction at 3 T for the assessment of hepatic fibrosis, 97th Radiological Society of North
America, (Chicago, '11.11).

- 58 -

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Senior Assistant Professor

KOBATA Takashi

Vascular surgery

Assistant Professor

NISHIZAWA Hisateru Cardiovascular surgery

Assistant Professor

NONAKA Toshimichi

Cardiovascular surgery

Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Assistant Professor

MIKAMI Naofusa

Cardiovascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

- 59 -

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name

Field of Specialization

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Professor

USUDA Katsuo

Senior Assistant Professor

AIKAWA Hirokazu

thoracic surgery, lung cancer, video assisted thoracoscopic surgery

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

thoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy- 60 -

Publications
Originals
0660B001

Y.Machida, Y.Ueda, M.Shimasaki, K.Sato, M.Sagawa, S.Katsuda, T.Sakuma: Relationship of aquaporin 1,3,and 5
expression in lung cancer cells to cellular differentiation, invasive growth, and metastasis potential, Hum. Pathol.,
42:669-678, 2011.

0660B002

K.Usuda, Xi.Zhao, M.Sagawa, M.Matoba, Y.Kuginuki, M.Taniguchi, Y.Ueda, T.Sakuma: Diffusion-weighted imaging
is superior to positron emission tomography in the detection and nodal assessment of lung cancers, Ann. Thorac.
Surg., 91:1689-1695, 2011.

0660B003(J.F.Guo), K.Higashi, Y.Ueda, Y.Ishigaki, T.Sakuma, M.Oguchi, T.Takegami, Y.Ohta, L.Zhang, K.Xu, H.Nishida,
H.Tonami: VEGF-A and its isoform VEGF121 mRNA expression measured by quantitative real-time RT-PCR:
correlation with F-18 FDG uptake and aggressiveness of lung adenocarcinoma: preliminary study, Ann. Nucl.
Med., 25:29-36, 2011.

0660B004(K.Hiroshima), H.Dosaka-Akita, K.Usuda, S.Ogura, Y.Kusunoki, T.Kodama, Y.Saito, M.Sato, Y.Tagawa, M.Baba,
T.Hirano, T.Horai, Y.Matsuno: Cytological characteristics of pulmonary pleomorphic and giant cell carcinomas,
Acta Cytol., 55:173-179, 2011.

0660B005(Y.Kibe), C.Uotani, M.Tabata, M.Sagawa, T.Kobayashi: How well are the guidelines of the Japanese society of CT
screening known? -Result of a survey by questionnaire performed among medical facilities for detailed
examinations-, The Journal of the Japanese Society of CT Screening, 18:82-87, 2011 (in Japanese) .

0660B006

M.Sagawa, H.Saito, R.Machii, T.Nakayama, T.Sobue, C.Hamashima, T.Kakizoe, K.Usuda, H.Aikawa, M.Ueno,
Y.Machida, M.Tanaka, T.Sakuma: A method of quality control of cancer screening using "Checklist for cancer
screening", Japanese Association for Cancer Detection and Diagnosis., 19:145-155, 2011 (in Japanese) .

Case Reports
0660D001

S.Maeda, M.Sugita, M.Sagawa, Y.Ueda, T.Sakuma: Solitary fibrous tumor of the pleura suddenly induced
hypoglycemia before surgical treatment, Ann. Thorac. Cardiovasc. Surg., 17:293-296, 2011.

Short Communications
0660E001

M.Sagawa, M.Tanaka, S.Mizukami, K.Nishida, K.Nishii, K.Usuda, H.Aikawa, Y.Machida, M.Ueno, T.Sakuma:
Recruitment for "A pilot study of randomized controlled trial to evaluate the efficacy of lung cancer screening by
thotacic CT", J. Kanazawa. Med. Univ., 36:25-32, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0660I001

K.Usuda, M.Sagawa, X.Zhao, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, T.Sakuma: Comparative studyof diffusion-weighted magnetic resonance imaging and PET-CT to detect non-small cell lung cancer and its nodal
involvement, 23rd European Congress of Radiology 2011, (Vienna, '11.03).

0660I002

H.Minato, N.Kurose, M.Fukushima, T.Nojima, M.Ueno, K.Usuda, M.Sagawa, T.Sakuma: Hepatoid adenocarcinoma
with a peripheral mucinous bronchioloalveolar growth pattern, 2011 Pulmonary pathology society biennial meeting,(New York, '11.08).

- 61 -

0420

Department of Surgical Oncology

Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Assistant Professor

YOKOI Miki

Surgery of breast cancer

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases., Surgical treatment of breast cancer

Faculty

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research・ A treatment strategy for advanced pancreato-biliary cancer, based on the pattern of tumor invasion
・ Investigation concerning laparoscopic surgical procedure for safe and secure operation, and its establishment.
・ Study of generalization and standardization for laparoscopic surgery in the gastrointestinal disease.
・ Study of safeness in the laparoscopic surgery for malignant disease and functional preserving laparoscopic operation.
・ Study on the education and training for laparoscopic surgery.
・ Introduction of the recently evolving engineering and robotics to laparoscopic surgery.

Books
0420A001

M.Noguchi, M.Yokoi, Y.Nakano, Y.Ono, T.Kosaka: Axillary Reverse Mapping in Breast Cancer, Radioisotopes Applications in bio-medical science (Nirmal Singh), 273-288, Intech, Croatia, 2011.

Publications
Originals
0420B001(M.Sugiyama), C.Kunisaki, H.Kato, T.Imada, H.Shimada, K.Hirata, T.Kosaka, M.Yoshida, M.Kitajima, T.Aiko:
Utility of alendronate in metabolic bone diseases after gastrectomy, Jpn. J. Gastroenterol Surg, 44:361-373, 2011
(in Japanese) .

0420B002

N.Ueda, T.Sawa, T.Kosaka: Type of lymph node metastasis and significance of lymphadenectomy in intrahepatic
bile duct carcinoma of the left lobe, J. Kanazawa. Med. Univ., 36:19-24, 2011 (in Japanese) .

- 62 -

0420B003

N.Ueda, T.Sawa, T.Kosaka: Improvement of the outcome of surgical treatment for hilar cholangiocarcinoma, J.
Kanazawa. Med. Univ., 36:77-82, 2011 (in Japanese) .

Reviews
0420C001

M.Noguchi, M.Inokuchi, Y.Ohno, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka: Oncological and cosmetic outcome inbreast cancer patients undergoing "moving window" operation, Breast Cancer Res. Treat., 129:849-856, 2011.

Case Reports
0420D002

M.Kaito, H.Iwao, E.Kinoshita, H.Funaki, O.Tachibana, M.Matsui: A case of Castleman disease with statusepileptics originating from focal cortical dysplasia, Clinical Neurology, 51:487-492, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0420I001

T.Ohnishi, S.Kinami, Y.Tomita, Y.Ohno, M.Yokoi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, T.Kosaka: The
application of USAD or EBVS for the prevention of the postoperative lymphorrhea after the lymph node dissection
in gastric cancer surgery, 9th International gastric cancer congress, (Seoul, '11.04)，9th International gastriccancer congress program book, 177, 2011.

0420I002

S.Kinami, T.Kosaka, T.Ohnishi, Y.Ohno, Y.Tomita, M.Yokoi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, S.Fushida,
T.Fujimura, T.Ohta: The life prognosis of patients performed the function-preserving gastrectomy for gastriccancer, 9th International gastric cancer congress, (Seoul, '11.04)，9th International gastric cancer congress
program book, 200, 2011.

0420I003

T.Kosaka, D.Kaida, T.Ohnishi, Y.Tomita, Y.Ohno, M.Noguchi, H.Funaki, S.Kinami, K.Omote, Y.Nakano, N.Ueda,
M.Noguchi: S-1 and cisplatin regimen followed by conversion gastrectomy for borderline resectable AGC, 9thInternational gastric cancer congress, (Seoul, '11.04)，9th International gastric cancer congress program book,
214, 2011.

0420I004

Y.Tomita, S.Kinami, T.Ohnishi, Y.Ohno, M.Yokoi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, M.Noguchi, T.Kosaka:
The occurrence and the measures of the delayed gastric empting after gastric surgery, 9th International gastriccancer congress, (Seoul, '11.04)，9th International gastric cancer congress program book, 297, 2011.

0420I005

Y.Ono, T.Onishi, Y.Tomita, M.Yokoi, H.Funaki, S.Kinami, K.Omote, N.Ueda, Y.Nakano, M.Noguchi, T.Kosaka,
N.Kurose: A breast cancer case having metastasis to the intramammary sentinel lymph node, The International
college of Surgeons The 57th Annual congress of the Japan section and the 27th colorectal conference in Aichi,(Nagoya, '11.06)，The International college of Surgeons The 57th Annual congress of the Japan section and the27th colorectal conference in Aichi proceedings, 68, 2011.

0420I006

T.Onishi, S.Kinami, Y.Tomita, Y.Ono, M.Yokoi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, T.Kosaka: The effect of
the surgical energy devices for the prevention of the postoperative lymphorrhea after the gastrectomy followed by
the lymph node dissection, The international college of surgeons The 57th Annual congress of the Japan section
and the 27th colorectal conference in Aichi, (Nagoya, '11.06)，The international college of surgeons The 57th
Annual congress of the Japan section and the 27th colorectal conference in Aichi proceedings, 80, 2011.

0420I007

Y.Tomita, S.Kinami, T.Ohnishi, Y.Ohno, M.Yokoi, H.Funaki, K.Omote, N.Ueda, Y.Nakano, T.Kosaka: The
strategy for prevention of the delayed gastric empting after gastric surgery., The 57th Annual congress of theJapan section and the 27th colorectal conference in Aichi, (Nagoya, '11.06)，The 57th Annual congress of theJapan section and the 27th colorectal conference in Aichi proceedings, 81, 2011.

0420I008

T.Ito, H.Kitakata, S.Kinami, K.Kawaura, T.Kosaka: Endoscopic full-thickness resec-tion for sentinel node negative
submucosal invasive gastric can-cer:fundamental experience in a procine model, UEGW2011, (Stockholm, '11.10).

0420I009

Y.Ohno, M.Noguchi, Y.Nakano, M.Noguchi, T.Kosaka: Oncologic and cosmetic outcome in breast cancer patients
who underwent "moving window" operation, San Antonio Breast Cancer Symposium, (San Antonio, '11.12).

- 63 -

0420I010

M.Noguchi, Y.Ohno, Y.Nakano, M.Noguchi, T.Kosaka: Feasibility of axillary reverse mapping during sentinel lymph
node biopsy in breast cancer, San Antonio Breast Cancer Symposium, (San Antonio, '11.12).

- 64 -

0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Professor

KAWAHARA Norio

Spinal surgery

Professor (Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma

Associate Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

OKUDA Tetsuhito

Spinal surgery

Senior Assistant Professor

MAEOKA Hayato

TraumaSenior Assistant Professor

ICHISEKI Toru

Hip surgery

Assistant Professor

HATO Taizo

Spinal surgery

Assistant Professor

HOSOKAWA Hidetaka Spinal surgery

Assistant Professor

HATANO Eijyu

Spinal surgery

Assistant Professor

MIAKI Kohei

Hip surgery

Assistant Professor

HIROMURA Kentaro

TraumaAssistant Professor

YASUDA Yoshihito

Spinal surgery

Assistant Professor

FUKUI Kiyokazu

Hip surgery

Assistant Professor

KITAMURA Kenji

Hip surgery

Assistant Professor

TOMIDOKORO Jun

Hip Surgery

Assistant Professor

NAKAGAWA Shintaro Hip surgery

Assistant Professor

MIKAMI Tomoaki

Hip surgery

Research Doctor

AKAGAWA Makoto

orthopaedic surgery

Research Doctor

ORITA Yugo

orthopaedic surgery

Research Doctor

TACHI Yoshiyuki

Spinal surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, spinal cord injury

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal- 65 -

cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4
is a digestive enzyme of CSPG . In future, we will clarify the mechanism.

Publications
Originals
0430B001

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, T.Matsumoto: Wear comparison between a highly crosslinked polyethylene and conventional polyethylene against a zirconia femoral head : Minimum 5-year Follow-Up, J.
Arthroplasty., 26:45-49, 2011.

0430B002

Y.Yasuda, T.Fujita, E.Hatano, T.Okuda, H.Hosokawa, T.Matsumoto: Perioperative complications of spine surgery
for lumbar canal stenosis in elderly patients, J Spine Res., 2:372-375, 2011.

0430B003(S.Jingushi), S.Ohfuji, M.Sofue, Y.Hirota, M.Itoman, T.Matsumoto, Y.Hamada, H.Shindo, Y.Takatori, H.Yamada,
Y.Yasunaga, H.Ito, S.Mori, I.Owan, G.Fuji, H.Ohashi, Y.Iwamoto, K.Miyanishi, T.Iga, N.Takahira, T.Sugimori,
H.Sugiyama, K.Okano, T.Karita, K.Ando, T.Hamaki, T.Hirayama, K.Iwata, S.Nakasone, M.Matsuura, T.Mawatari:
Osteoarthritis hip joints in Japan: involvement of acetabular dysplasia, J. Orthop. Sci., 16:156-164, 2011.

0430B004

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, K.Kitamura, T.Matsumoto: Should the well-fixed, uncemented femoral
components be revised during isolated acetabular revision?, Arch. Orthop. Trauma. Surg., 131:481-485, 2011.

0430B005

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: A radiological study of the true anatomical position of
the acetabulum in Japanese women, Hip Int., 21:311-316, 2011.

0430B007

M.Okada, M.Akagawa, S.Kaneko, K.Hiromura, H.Maeoka, T.Matsumoto: Clinical results of tongue type, Sanders
type 2 fractures of the calcaneus treated by percutaneous osteosynthesis, The Journal of the Japanese Society for
Surgery of the Foot., 32:128-132, 2011 (in Japanese) .

0430B009

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: The influence of femoroacetabular impingement after
surgery for slipped capital femoral epiphysis, Japanese Journal of Joint Diseases, 30:153-157, 2011 (in Japanese) .

0430B010(T.Fujita), T.Okuda, H.Hosokawa, E.Hatano, Y.Yasuda, N.Kawahara, T.Matsumoto: Microscopic bilateralfenestration via a unilateral approach for lumbar spinal canal stenosis, J Spine Res., 2:1372-1376, 2011 (inJapanese) .

0430B014(D.Tawara), J.Sakamoto, H.Murakami, N.Kawahara: Biomechanical assessment of changes in vertebral strength inosteoporosis during drug treatment by patient-specific CT-based finite element analysis, Japanese Journal of
Clinical Biomechanics., 32:113-119, 2011 (in Japanese) .

0430B015(Y.Endo), J.Sakamoto, T.Okayama, H.Murakami, N.Kawahara, K.Tomita: Stress analysis of the spinal cord incircumspinal decompression. -On influence of nerve root-, Japanese Journal of Clinical Biomechanics., 32:161166, 2011 (in Japanese) .

0430B016(N.Takano), K.Shintani, H.Sasaki, A.Kaneuji: Examination of the stress environment in hip osteoarthritis using asolid model, Japanese Journal of Clinical Biomechanics., 32:197-202, 2011 (in Japanese) .

0430B017

A.Kumagai, J.Sugama, M.Okuwa, T.Okuda, N.Kakiuti, A.Kanno, T.Nakatani: Relationship between interfacepressure and development of pressure ulcer in prone position surgery using hall frame, Jpn. J. P. U., 13:576-582,
2011 (in Japanese) .

Case Reports
0430D002(Y.Okamoto), H.Murakami, S.Demura, S.Kato, H.Hayashi, K.Inoue, N.Kawahara, K.Tomita, H.Tsuchiya: Total en
bloc spondylectomy for cervicothoracic spine(C7-T2) : a case report, J Spine Res., 2:1696-1698, 2011 (inJapanese) .

- 66 -

Short Communications
0430E001

T.Ichiseki, A.Kaneuji, Y.Ueda, S.Nakagawa, T.Mikami, K.Fukui, T.Matsumoto: Osteonecrosis development in anovel rat model characterized by a single application of oxidative stress, Arthritis Rheum, 63:2138-2141, 2011.

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

N.Kawahara: Total en-bloc spondylectomy for spinal tumors, 9th International Turkish Spine Congress, (Istanbul,'11.04).

0430G002

N.Kawahara: Timing of surgery around radiation and chemotherapy, 2nd Charité Spine Tumor Days, (Berlin,'11.05).

0430G003

N.Kawahara: Thoracic metastasis with cord compression, AOSpine Masters Knowledge Forum, (Davos, '11.12).

International Conference (Synposium)
0430H001

N.Kawahara: Corrective osteotomy for angular deformity of the spine, 9th International Turkish Spine Congress,(Istanbul, '11.04).

0430H002

N.Kawahara: Surgical strategy for spinal matastases, 9th International Turkish Spine Congress, (Istanbul, '11.04).

International Conference (Presentations)
0430I001

T.Okuda, Y.Tachi, N.Kawahara, N.Kato, Y.Ishigaki, E.Hatano, Y.Yasuda, T.Matsumoto: Hyaluronidase-4
expression in a rat spinal cord hemisection model, Second Annual Meeting of Cervical Spine Research Society Asia
Pacific Section (CSRS-AP 2011), (Busan, '11.04).

0430I002

T.Okuda, N.Kawahara, T.Fujita, A.Kaneuji, E.Hatano, T.Ichiseki, Y.Yasuda, K.Fukui, T.Matsumoto: Severe hip
contracture affects the contralateral side scoliosis in lumbar spine, The International Society for the Study of the
Lumbar Spine (ISSLS 2011), (Gothenburg, '11.06).

0430I003

A.Kaneuji, J.Tomidokoro, E.Takahashi, T.Sugimori, T.Ichiseki, K.Fukui, T.Matsumoto: Stem subsidence and strain
in the cement of polished tapered femoral stems versus rough stem, International Society of Orthopaedic Surgery
and Traumatology (SICOT 2011), (Prague, '11.09).

0430I004

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: How far above the true anatomical position can the cup
be placed during total hip arthroplasty?, International Society of Orthopaedic Surgery and Traumatology (SICOT
2011), (Prague, '11.09).

0430I005

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Hato, E.Hatano, T.Matsumoto: Does Hyaluronidase-4
digest chondroitin sulfate proteoglycans in a rat spinal cord hemisection model?, Neuroscience 2011, (Washington,'11.11).

- 67 -

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

SASAGAWA Yasuo

brain tumor

Assistant Professor

SIRAGA Syunsuke

general neurosurgery

Assistant Professor

YAMAMOTO Jiro

general neurosurgery

Assistant Professor

TORIGOE Keiichiro

general neurosurgery

Research Doctor

TSUKADA Tsuyoshi

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly- 68 -

1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Case Reports
0440D001

Y.Sasagawa, T.Akai, S.Itou, H.Iizuka: Multiple inraosseous inflammatory myofibroblastic tumors presenting with anaggressive clinical course, Neurosurgery, 69:1010-1015, 2011.

0440D002

Y.Sasagawa, T.Akai, S.Itou, H.Iizuka: De novo aneurysm in he feeding artery of a recurrent malignant glioma case report -, Neurol. Med. Chir. (Tokyo), 51:306-310, 2011.

0440D003

M.Kaito, H.Iwao, E.Kinoshita, H.Funaki, O.Tachibana, M.Matsui: A case of Castleman disease with statusepileptics originating from focal cortical dysplasia, Clinical Neurology, 51:487-492, 2011 (in Japanese) .

Others
0440F001

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting distraction osteogenesis for
craniosynostosis, Childs Nerv. Syst., 27:1770-1771, 2011.

0440F007

K.Okamoto, T.Akai, O.Tachibana, H.Iizuka: Clinical study of patients with metastatic brain tumor from lungcancer, survived more than two years, Stereotactic Radiotherapy., 15:129-134, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0440I001

T.Iida, K.Torigoe, J.Yamamoto, T.Akai, H.Iizuka: Transarticular screw fixation in subaxial cervical spin, 2nd
Annual meeting of asia spine 9th Japan-Korea conference on spinal surgery, (Fukuoka, '11.09).

0440I002

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting destraction osteogenesis for
craniosynostosis, 39th Annual meeting of the international society for pediatric neurosurgery, (Goa, India, '11.10).

0440I003

M.Yamashita, T.Akai, M.Kishibe, S.Kawakami: Craniosynostosis: A retrospective study of 46 cases, The 21st
Japan - China joint congress on plastic surgery, (Fukuoka, '11.11).

- 69 -

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

MORITA Reiji

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

NISHIO Akiko

Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

TAGUCHI Hisao

Plastic and Reconstructive Surgery

Assistant Professor

DOI Yujin

Plastic and Reconstructive Surgery

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

- 70 -

Publications
Others
0450F001

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting distraction osteogenesis for
craniosynostosis, Childs Nerv. Syst., 27:1770-1771, 2011.

Presentations at Conference
International Conference (Presentations)
0450I001

T.Akai, H.Iizuka, Y.Sasagawa, S.Siraga, S.Kawakami, M.Yamashita: Troubleshooting destraction osteogenesis for
craniosynostosis, 39th Annual meeting of the international society for pediatric neurosurgery, (Goa, India, '11.10).

0450I002

M.Yamashita, T.Akai, M.Kishibe, S.Kawakami: Craniosynostosis: A retrospective study of 46 cases, The 21st
Japan - China joint congress on plastic surgery, (Fukuoka, '11.11).

0450I003

A.Nishio, M.Yamashita, M.Kishibe, S.Kawakami: Rhinoplasty using spreader grafts for Japanese, The 21st Japan China joint congress on plastic surgery, (Fukuoka, '11.11).

- 71 -

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Senior Assistant Professor

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Assistant Professor

OSHIKIRI Takahiro

Pediatric surgery

Assistant Professor

YASUI Yoshitomo

Pediatric surgery

Research Doctor

KUWAHARA Tsuyoshi Pediatric surgery

Research Doctor

TAKAHASHI
Sadayoshi

Faculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Presentations at Conference
International Conference (Presentations)
0460I001

M.Kohno, H.Ikawa, H.Masuyama, T.Oshikiri, Y.Yasui, S.Takahashi, T.Kuwahara: Extended perineal anorectoplasty
to avoid damaging the rectal branch of pelvic plexus of imperforate anus with rectoprostatic urethral fistula,International Surgical Week/ISW2011, (Yokohama, '11.08).

- 72 -

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication
ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Professor

KITAGAWA Kazuko

Associate Professor(Additional Post)

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

cataract, thyroid ocular

Assistant Professor

FUJITA Nobuyuki

uveitisAssistant Professor

YAGUCHI Hiromoto

corneal epithelium, glsucoma

Assistant Professor

HAGIWARA Kenta

ocular infection

Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology

Assistant Professor

OSADA Hiromi

cataract, ophthalmology

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

- 73 -

Publications
Originals
0470B001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura: Ultraviolet B-induced
expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, Mol. Vis., 17:159169, 2011.

0470B002

Y.Yamashiro, H.Sasaki, N.Ibaraki, K.Nagai, Y.Kawakami, H.Yaguchi, N.Fujita, H.Osada, K.Sasaki: Cyclindependent kinase inhibitor p16 and p21 expression, and cell cycle change in human lens epithelial cell line SRA
01/04 following contact inhibition in normal culture, Ophthalmic Res., 46:38-43, 2011.

0470B003

H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, N.Hatsusaka, DH.Sliney, K.Sasaki: UV-B exposure to the eyedepending on solar altitude, Eye Contact Lens, 37:191-195, 2011.

0470B004

H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura: Identification of the COL2A1 mutation inpatients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, Genet. Test.
Mol. Biomarkers, 15:231-237, 2011.

0470B005

M.Fukuda, N.Shibata, H.Osada, Y.Yamashiro, H.Sasaki: Vitreous and aqueous penetration of orally and topicallyadministered moxifloxacin, Ophthalmic Res., 46:113-117, 2011.

0470B006(N.Fatma), P.Singh, B.Chhunchha, E.Kubo, T.Shinohara, B.Bhargavan, DP.Singh: Deficiency of Prdx6 in lensepithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis, Am. J. Physiol., Cell
Physiol., 301:C954-C967, 2011.

0470B007(D.Oyama), Y.Adachi, N.Hatsusaka, T.Kasahara, M.Yumoto, I.Hashimoto, G.Uehara: Evaluation of an IsoscelesTriangle-Coil phantom for magnetoencephalography, IEEE Trans. Magn., 47:3853-3856, 2011.

0470B008(N.Fujii), T.Kawaguchi, H.Sasaki, N.Fujii: Simultaneous stereoinversion and isomerization at the Asp-4 residue in
βB2-crystallin from the aged human eye lenses, Biochemistry, 50:8628-8635, 2011.

0470B009(B.Chhunchha), N.Fatma, B.Bhargavan, E.Kubo, A.Kumar, DP.Slngh: Specificity protein, Sp1-mediated increased
expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress, Cell
Death. Dis., 2, e234; 1-13, 2011.

0470B011

M.Fukuda, H.Yaguchi, N.Fujita, I.Shibata, H.Osada, N.Shibata, H.Sasaki: Effect of sodium hyaluronate eyedrops
on corneal cells, Journal of the eye., 28:549-552, 2011 (in Japanese) .

0470B012

M.Fukuda, I.Shibata, K.Hagiwara, H.Yaguchi, H.Sasaki: Generic versions of latanoprost ophthalmic solution
evaluated for safety to corneal epithelial cells, Journal of the eye., 28:849-854, 2011 (in Japanese) .

0470B013

N.Mita, N.Hatsusaka, E.Shibata, Y.Sakamoto, H.Osada, I.Shibata, N.Shibata, H.Yaguchi, K.Sasaki, H.Sasaki:
Assessing predictive accuracy of lens transparency property via 10-year follow-up in Japanese, Journal of the eye.,
28:1503-1507, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0470I001

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, F.Jonasson, Y.Sakamoto, K.Sasaki: Factors influencing retinal image
contrast -Reykjavik Eye Study, The Association for Research in Vision and Ophthalmology, (Florida, '01.05).

0470I002

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki: Acuteocular damage threshold of 60 GHz millimeter-wave band exposure, 10th International Conference European
Bioelectromagnetics Association, (Rome, '11.02).

0470I003

N.Mita, N.Hatsusaka, E.Shibuya, Y.Sakamoto, N.Yamamoto, H.Sasaki: Aging change of retinal image contrast in
the eyes with transparent lenses of Japanese, The Association for Research in Vision and Ophthalmology, (Florida,'11.05).

- 74 -

0470I004(K.Nagai), Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, Y.Kawakami, K.Sasaki, H.Sasaki, F.Jonasson: Evaluationof crystalline lens waterclefts by image analysis Reykjavik Eye Study, The Association for Research in Vision andOphthalmology, (Florida, '11.05).

0470I005

M.Kojima, S.Yamaguchi, T.Okuno, Y.Ishiba, K.Sasaki, H.Sasaki: Investigation of the mechanism of near-infraredinduced cataract, The Association for Research in Vision and Ophthalmology, (Florida, '11.05).

0470I006

N.Hatsusaka, E.Shibuya, N.Mita, Y.Sakamoto, H.Yaguchi, S.Inagaki, H.Osada, N.Shibata, K.Sasaki, H.Sasaki:
Relationship between 10-year-change in refraction of crystallines lens and aging, The Association for Research in
Vision and Ophthalmology, (Florida, '11.05).

0470I007

M.Fukuda, S.Inagaki, K.Hagiwara, H.Yaguchi, H.Osada, N.Shibata, H.Sasaki: Safety evaluation of feneric versionsof latanoprost ophthalmic solution for corneal epithelial cells, The Association for Research in Vision andOphthalmology, (Florida, '11.05).

0470I008

Y.Yoshitake, H.Osada, T.Ikeda, Y.Yoshitomi, Y.Ishigaki, H.sasaki, H.Yonekura: Ultraviolet B-induced expressionof amphiregulin and growth differentiation factor 15 in human lens epithelial cells, 36th FEBS Congress, (Torino,'11.06).

0470I009(A.Koike), Y.Suzuki, M.Kojima, T.Sakai, K.Wakw, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki: An investigation of thehest transport mechanism under the millimeter -wave exposure considering the convection in the anterior chamberof rabbiy's eye, XXX URSI General Assembly and Scientific Symposum of International union of Radio Science,(Istanbul, '11.08).

0470I010

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K/Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki:
Investigation of acute ocular in jury threshold by 76 Ghz band exposure in rabbits, XXX URSI General Assemblyand Scientific Symposum of International union of Radio Science, (Istanbul, '11.08).

- 75 -

0480

Department of Otolaryngology

Faculty
Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

HORIGUTI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology

Assistant Professor

YAMADA Kanako

Rhinology, generel otology

Assistant Professor

SAKAI Aya

Sleep apnea syndrome

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

NOMURA Yuko

Otorhinolaryngology

Keywords of Researcholfactory disorders, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, headand neck tumor surgery, thyroid tumor surgery, skull base surgery, sleep apnea & snoar surgery

Outline of Research
Basic and clinical research for the diagnosis and treatment of olfactory disorders
Central mechanism of auduological function by MEG
Clinical research for head and neck tumor and oncology
Research for thyroid and parathyroid gland
Clinical reserach for snoar and sleep apnea

Books
0480A003

H.Shiga, T.Miwa: Innovative imaging of olfactory nerve connectivity “Thallium-201 olfacto-scintigraphy”, Reimer,
A. (eds); Horizons in World Physics 273, 223-231, Nova Science Publishers, New York, 2011.

Publications
Originals
0480B001(K.Washiyama), H.Shiga, K.Hirota, A.Tsuchida, J.Yamamoto, S.Yagi, T.Yoshizaki, M.Furukawa, R.Amano, T.Miwa:
Biological safety of nasal thallium-201 administration: a preclinical study for olfacto-scintigraphy, J. Radiat. Res.,
52:450-455, 2011.

0480B002

H.Shiga, J.Taki, M.Yamada, K.Washiyama, R.Amano, Y.Matsuura, O.Matsui, S.Tatsutomi, S.Yagi, A.Tsuchida,
T.Yoshizaki, M.Furukawa, S.Kinuya, T.Miwa: Evaluation of the olfactory nerve transport function by SPECT-MRI
fusion image with nasal thallium-201 administration, Mol. Imaging Biol., 13:1262-1266, 2011.

- 76 -

0480B004

M.Matoba, I.Toyota, Y.Kuginuki, H.Tonami, T.Miyazawa, Y.Shimode, H.Tsuji, T.Miwa: Efficacy of diffusionweighted MR imaging and PET/CT for predicting and detecting early response to chemoradiation therapy
squamous cell carcinoma in the head and neck, J. J. M. R. M., 31:115-123, 2011 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0480H001

T.Miwa: Visualization of Olfactory Nerve Transduction using Thallium-201 Intranasal Administration, 14th
International Rhinologic Society & 30th International symposium on infection and allergy of the nose, (Tokyo,'11.09).

International Conference (Presentations)
0480I001

H.Shiga, J.Taki, S.Kinuya, N.Watanabe, H.Tonami, K.Washiyama, R.Amano, M.Furukawa, T.Miwa: Olfactory bulb
neurogenesis and olfactory nerve transport., Keystone symposia, Adult neurogenesis, (Taos, USA, '11.01).

0480I002

H.Shiga, J.Taki, S.Kinuya, N.Watanabe, H.Tonami, K.Washiyama, R.Amano, M.Furukawa, T.Miwa: Reduced
olfactory nerve transport function and olfactory bulb volume in patients with olfactory disorders., The 14th
Congress of the International Rhinologic Society. The 30th International Symposium on Infection and Allergy of theNose, (Tokyo, '11.09).

0480I003

J.Yamamoto, H.Shiga, K.Washiyama, R.Amano, T.Miwa: Increase of olfactory nerve viability by pre-medication of
Kampo medicine TJ-137 after paclitaxel administration in vivo, International Rhinologic Society International
Symposium on Infection and Allergy of the Nose, (Tokyo, '11.09).

0480I004

Y.Suzuka, A.Horiguti, K.Yamada, A.Sakai, T.Miwa: Long-term cases of eosinophilic otitis media, 28th Polizter
society meeting, (Athens, '11.09)，28th Polizter society meeting proceeding, 2011.

- 77 -

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology ， Dermatomycosis

Associate Professor

NISHIBU Akiko

Immunology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Assistant Professor

TAKEDA Kiminobu

Medical mycology

Assistant Professor

FUJITA Jun

Medical mycology

Assistant Professor

HASEI Maki

Skin tumor and growth factores，Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Research Doctor

HATTA Jyunko

Image analysis

Research Doctor

NANBU Masayuki

Dermatopathology

Research Doctor

YOSHIMURA Rieko

Medical mycology

Research Doctor

KOJIMA Kiyoto

genetic diagnosis

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, phylogeny, taxonomy, molecular epidemiology, molecular typing, electron
microscopy, dermatopathology, skin tumor, decubitus, immunopathology, immunology, langerhans cell

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Books
0490A002

T.Mochizuki, K.Anzawa: Deep mycoses in Japan, World Congress of Dermatology 2011, 393-397, Special Book,
Seoul Korea, 2011.

- 78 -

0490A003

T.Mochizuki, M.Kawasaki, K.Anzawa: Genetic variation of fungus in Asia, World Congress of Dermatology 2011,375-379, Special Book, Seoul Korea, 2011.

Publications
Originals
0490B001(R.Kano), T.Yamada, K.Makimura, M.Kawasaki, T.Mochizuki, H.Kamata, A.Hasegawa: Arthroderma benhamiae(The Teleomorph of Trichophyton mentagrophytes) Mating Type-Specific Genes, Mycopathologia, 171:333-337,
2011.

0490B002

M.Kawasaki, K.Anzawa, T.Ushigami, J.Kawanishi, T.Mochizuki: Multiple gene analyses are necessary tounderstand accurate phylogenetic relationships among Trichophyton Species, Med. Mycol. J., 52:245-254, 2011.

0490B003

K.Anzawa, M.Kawasaki, M.Hironaga, T.Mochizuki: Genetic ｒelationship between Trichophyton mentagrophytesvar. interdigitale and Arthroderma vanbreuseghemii, Med. Mycol. J., 52:223-227, 2011.

0490B004

K.Anzawa, T.Mochizuki, A.Nishibu, H.Ishizaki, K.Kamei, Y.Takahashi, M.Fujihiro, H.Shinoda: Molecularepidemiology of Trichophyton tonsurans strains isolated in Japan between 2006 and 2010 and their susceptibility tooral antimycotics, Jpn. J. Infect. Dis., 64:458-462, 2011.

0490B005

K.Takeda, T.Ushigami, M.Terada, N.Wakamatsu, A.Nishibu, H.Tanabe, M.Yanagimoto, K.Anzawa, M.Kawasaki,
T.Mochizuki, H.Ishizaki: Twenty-three cases of tinea capitis at the Kanazawa Medical University Hospital in thepast 10 years, The Japanese Journal of Dermatology, 121:1057-1061, 2011 (in Japanese) .

Reviews
0490C001

M.Kawasaki: Verificatin of taxonomy of dermatophytes based on mating results and phylogenetic analyses, Med.
Mycol. J., 52:291-295, 2011.

Others
0490F001

M.Terada, J.Fujita, S.Watanabe, M.Kawasaki, H.Tanabe, K.Anzawa, T.Mochizuki: Olecranon bursa with Fusarium

solani infection in an otherwise healthy patient, Mycoses, 54:853-855, 2011.
0490F002(Y.Kato), N.Kikuchi, A.Nishibu, M.Ohtsuka, T.Yamamoto: Letter:Two cases of metastases to the scalp bone
mimicking epidermoid cyst, Dermatol Online J., 17:13, 2011.

Presentations at Conference
International Conference (Key Note Lecture)
0490G001

T.Mochizuki: Recent Molecular Approaches for the Epidemiology of Dermatomycoses, 18th Annual meeting of
Korean Society for Medical Mycology, (Seoul, '11.09).

International Conference (Synposium)
0490H001

T.Mochizuki: Recent advances and problems in diagnosis of fungal diseases in dermatology, 13th International
Congress of Mycology, (Sapporo, '11.09).

International Conference (Presentations)
0490I001

M.Hasei, K.Anzawa, M.Kawasaki, H.Tanabe, T.Mochizuki: A case of phaeohyphomycosis caused by exophiala
jeanselmei producing multiple skin lesions, The 22nd World Congress of Dermatology 2011 (WCD 2011), (Korea,'11.05).

- 79 -

0500

Department of Urogenital Surgery

Title

Name

Field of Specialization

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Associate Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Associate Professor

MORIYAMA Manabu

kidney transplantation, kidney stone disease

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

CHIKAZAWA Ippei

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

ISHII Takeo

general urology

Faculty

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001(T.Tanaka), K.Miyazawa, T.Tsukamoto, T.Kuno, K.Suzuki: Pathobiology and chemoprevention of bladder cancer,
J. Oncol., 2011:528353;1-23, 2011.

0500B002

N.Morita, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki: Evolution of strategy to measure urinary
supersaturation, Acta Urol. Jpn., 57:35-38, 2011 (in Japanese) .

0500B003(K.Fujimoto), Y.Hirao, Y.Ohashi, Y.Shibata, K.Fuji, H.Tsuji, N.Shimizu, K.Miyazawa, M.Nagata, M.Ohtani,
R.Furuya, E.Boku: Changes in serum prostate specific antigen and testosterone levels after chlormadinone acetate
treatment in patients with benign prostatic hyperplasia : A prospective multicenter clinical study, Acta Urol. Jpn.,
57:177-183, 2011 (in Japanese) .

0500B004

T.Shimasaki, K.Miyazawa, M.Moriyama, T.Tanaka, I.Sato, N.Nakaya, H.Nakajima, A.Kubo, K.Suzuki, Y.Motoo:
Combination chemotherapy of docetaxel and uft against hormone refractory prostate cancer, Acta Urol. Jpn.,
57:163-166, 2011 (in Japanese) .

- 80 -

Reviews
0500C002

K.Miyazawa, K.Suzuki: Gene expression and its role on urolithiasis, Clin. Calcium, 21:1473-1479, 2011 (inJapanese) .

0500C003

M.Moriyama: Diet therapy and life guidance to prevent calcium stones, Clin. Calcium, 21:1522-1529, 2011 (inJapanese) .

Case Reports
0500D001(I.Ishikawa), K.Morita, S.Hayama, T.Nakagawa, I.Araki, K.Higashi, K.Miyazawa, K.Suzuki, T.Nojima: Imaging ofacquired cystic disease-associated renal cell carcinoma by contrast-enhanced ultrasonography with perflubutane
microbubbles and positron emission tomography-computed tomography, Clin. Exp. Nephrol., 15:136-140, 2011.

0500D003

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, A.Nakagawa, N.Kurose: Composite pheochromocytoma withganglioneuroma in the adrenal gland: A case report, J. Kanazawa. Med. Univ., 36:83-85, 2011 (in Japanese) .

0500D004

I.Chikazawa, N.Morita, K.Suga, M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki, H.Astumi, H.Minato, K.Sato:
Adrenal myelolipoma: A report of two cases, J. Kanazawa. Med. Univ., 36:86-89, 2011 (in Japanese) .

0500D005

I.Chikazawa, T.Tanaka, K.Suzuki, K.Sato: A case of renal oncocytonma with cystic change, Japanese Journal of
Clinical Urology, 65:1031-1033, 2011 (in Japanese) .

Others
0500F003

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

0500F004

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

0500F005

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

- 81 -

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Professor

MAKINODA Satoru

Associate Professor

Field of Specialization

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines
Gynecologic Pathology, Tumor Virology, Sexually Transmitted
SASAGAWA Toshiyuki
Infection Research, Immunology

Associate Professor(Additional Post)

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

Senior Assistant Professor

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

SASAKURA Chihaya

perinatal medicine, perinatal diagnosis

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

YAMAGUCHI Naotaka perinatal medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

- 82 -

Publications
Originals
0510B001(K.Matsushita), T.Sasagawa, M.Miyashita, A.Ishizaki, A.Morishita, N.Hosaka, K.Saikawa, S.Hoshina, X.Bi,
H.Ichimura: Oral and cervical human papillomavirus infection among female sex workers in Japan, Jpn. J. Infect.
Dis., 64:34-39, 2011.

0510B002(K.Shigehara), T.Sasagawa, J.Doorbar, S.Kawaguchi, Y.Kobori, T.Nakashima, M.Shimamura, Y.Maeda, T.Miyagi,
Y.Kitagawa, Y.Kadono, H.Konaka, A.Mizokami, E.Koh, M.Namiki: Etiological role of human papillomavirus
infection for inverted papilloma of the bladder, J. Med. Virol., 83:277-285, 2011.

0510B003(K.Shigehara), S.Kawaguchi, T.Sasagawa, K.Furubayashi, M.Shimamura, Y.Maeda, H.Konaka, A.Mizokami, E.Koh,
M.Namiki: Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese menwith urethritis, and risk factors for detection of urethral human papillomavirus infection, J. Infect. Chemother.,
17:487-492, 2011.

0510B004(K.Shigehara), T.Sasagawa, S.Kawaguchi, T.Nakashima, M.Shimamura, Y.Maeda, H.Konaka, A.Mizokami, E.Koh,
M.Namiki: Etiologic role of human papillomavirus infection in bladder carcinoma, Cancer, 117:2067-2076, 2011.

0510B005

M.Rahman, T.Sasagawa, R.Yamada, A.Kingoro, H.Ichimura, S.Makinoda: High prevalence of intermediate-risk
human papillomavirus infection in uterine cervices of Kenyan women infected with human immunodeficiency virus,
J. Med. Virol., 83:1988-1996, 2011.

Presentations at Conference
International Conference (Presentations)
0510I001

R.Fujii: The involvement of granulocyte colony-stimulating factor (G-CSF) in the release of a mature oocyte, The
27th of Annual Meeting of the ESHRE, (Stockholm, '11.07).

0510I002

H.Tomizawa: A novel treatment of luteinized unruptured follicle caused by ovulation induction using clomiphene –human chorionic gonadotropin, The 27th of Annual Meeting of the ESHRE, (Stockholm, '11.07).

0510I003

H.Takagi, N.Yamaguchi, N.Neyatani, T.Waseda, H.Tomizawa, Y.Oka, S.Makinoda: Efficacy and safety of long-term
Dienogest therapy for endometriosis, 11th World Congress on Endometriosis, (Montpellier, '11.09).

0510I004

T.Sasagawa: The Prevalance of Cervical Intraepithelial Neoplasia and Condyloma Acuminata in Japanese Women,
27th International Papillomavirus Conference, (Berlin, '11.09).

0510I005

T.Waseda, S.Makinoda: Evaluation of the transcatheter arterial infusion of CDDP as NAC for cervical cancer by
MRI and its prognosis, 21st World Congress on Ultrasound in OB/GYN, (Los Angels, '11.09).

0510I006

T.Shibata, N.Neyatani, T.Waseda, R.Fujii, S.Makinoda: A useful case of PET-CT in the diagnosis of malignant
transformation of mature cystic teratoma, 2nd Biennial Meeting of Asian Society of Gynecologic Oncology, (Seoul,'11.11).

- 83 -

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

SHIRAISHI Miharu

Clinical anesthesia, Pain medicine, Palliative medicine

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Assistant Professor

NISHIIKE Satoshi

Clinical anesthesia, Nerve block, Vascular reactivity

Assistant Professor

SUGIURA Soichiro

Clinical anesthesia, Intensive care medicine, Vascular reactivity

Assistant Professor

HORIUCHI Katsura

Clinical anesthesia, Intensive care medicine

Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, ShockAssistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia

Assistant Professor

MURATA Yuriko

Clinical anesthesia

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity

Assistant Professor

BEN Asami

Clinical anesthesia

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Originals
0520B001(Z.Wajima), H.Tsuchida, T.Shiga, K.Imanaga, T.Inoue: Intravenous landiolol, a novel ß1-adrenergic blocker,
reduces the minimum alveolar concentration of sevoflurane in women, J. Clin. Anesth., 23:292-296, 2011.

0520B002

A.Magara, Y.Yamaoka, Y.Murata, M.Shiraishi, H.Tsuchida: Is the incidence of postoperative pulmonary
thromboembolism in Japan lower than that in the western countries?, The Japanese journal of anesthesiology.,
60:511-515, 2011 (in Japanese) .

- 84 -

Reviews
0520C001

H.Tsuchida: Lifelines in the affected area after an earthquake, Journal of clinical anesthesia., 35:1774-1779, 2011
(in Japanese) .

Presentations at Conference
International Conference (Synposium)
0520H001(K.Ogawa), M.Ogawa, Y.Motoo: Kampo Therapy for Cancer Care: Significance as Supportive Measure, 1stInternational Symposium for Japanese Kanpo Medicine, (Munich, '11.11).

International Conference (Presentations)
0520I001

H.Tsuchida, Y.Tanaka, T.Hiramatsu: Hemodynamic effects of landiolol, an ultra-short-acting beta-1 selective
blocker, on endotracheal intubation in elderly hypertensive patients, Annual Meeting of the American Society ofAnesthesiologists, (Chicago, '11.10).

0520I002

S.Nishiike, T.Hiramatsu, Y.Tanaka, H.Tsuchida: he decrease in alpha-adrenergic vasoconstriction of septic rat
aorta is partly antagonized by the administration of high mobility group box-1 antibody, Annual Meeting of theAmerican Society of Anesthesiologists, (Chicago, '11.10).

- 85 -

0650

Department of Rehabilitation Medicine

Faculty
Title

Name

Professor

KAGECHIKA Kenji

Senior Assistant Professor(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Presentations at Conference
International Conference (Synposium)
0650H001

M.Nakata: Criteria for acknowledgement and compensation for occupational musculoskeletal disorders in Japan,
and their related arguments, The first Japan-Korea joint symposium on Work-related Musculoskeletal Disorders,(Hiroshima, '11.02).

- 86 -

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Associate Professor

OGURA Kenichi

Emergency, Neurosurgery

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

GOTO Tetsuro

Emergency

Research Doctor

IWAI Junichi

Emergency

Research Doctor

WATANABE Atsushi

Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

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0570

District medical

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Senior Assistant Professor(Additional Post)

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Case Reports
0570D001

A.Tempaku, T.Mizuno, M.Hasegawa, A.Saito, N.Yamashita, H.Atsumi, T.Ito, K.Ishigami, M.Miura, Y.Izumi,
N.Kurose, H.Minato, T.Nojima, T.Kanda, N.Takekoshi: Interleukin-6 expressing colon cancer with multiple hepatic
metastases, J. Kanazawa. Med. Univ., 36:106-110, 2011.

0570D002

T.Mizuno, K.Ishigami, D. Sakamoto, R.Isahii, T.Kanda: Two types of Brugada-like ST-elevation in patients withfebrile infection, J. Kanazawa. Med. Univ., 36:124-126, 2011.

Others
0570F001

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

0570F002

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

0570F003

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0570I001

Y.Izumi, N.Takekoshi, T.Kanda, T.Mizuno, Y.Ozawa, Y.Kasamaki, M.Ohta, T.Nakayama, H.Kawamura,
M.Mahemuti, D.Himit: Differences in organ damage for dipper and non-dipper patterns in 2 ethnic groups,
European Society of Hypertension (ESH) 2011: 21st European Meeting on Hypertension, (Milan, '11.06).

- 88 -

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

YOSHIMURA Hiroshi temporomandibular joint disorders, stomatology, neuroscience

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

Senior Assistant Professor

AOKI Hideaki

Rehabilitation Medicine, Oral and Maxillofacial Surgery

Senior Assistant Professor

ONO Tohru

oral and maxillofacial surgery, oral infection, temporomandibular joint
disorders, oral oncology, dental implant

Assistant Professor

HONJYO Miho

Orthodontics

Assistant Professor

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0530B001

H.Yoshimura, M.Honjyo, T.Sugai, K.Kaneyama, N.Segami, N.Kato: Correlation between stimulation strength andonset time of signal traveling within the neocortical neural circuits under caffeine application, Neurosci. Res.,
70:370-375, 2011.

0530B002

H.Yoshimura, M.Honjyo, T.Sugai, M.Kawabe, K.Kaneyama, N.Segami, N.Kato: Influences of audio-visualenvironments on feelings of deliciousness during having sweet foods: an electroencephalogram frequency analysis
study, Nutr. Neurosci., 14:210-215, 2011.

Case Reports
0530D001

K.Kaneyama, N.Segami, R.Nishiura, H.Yoshmura: Internal derangement of the temporomandibular joint withmouth-closing disturbance caused by a thickness of retrodiscal tissue: A case report., J. Oral Maxillofac. Surg.,
69:1052-1055, 2011.

- 89 -

- 90 -

School of Nursing

8010

Basic Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing

Associate Professor

SAKAI Keiko

Communication Skills

Senior Assistant Professor

MATSUI Yuko

Fundamental Nursing

Assistant Professor

KYUJI Kazuyo

Nursing Students and Proffessional Sprit

Assistant Professor

OKAYAMA Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desireKeywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

Publications
Others8010F002

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

8010F003

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

8010F004

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
8010I001(K.Kasai), K.Kyuji: Self-evaluation and peer evaluation of nursing practice ability in terms of background of clinicalnurses, The 3rd Korea-China-Japan Nursing Conference, (Korea, '11.10)，The 3rd Korea-China-Japan Nursing
Conference Nurses` Social responsibility and Role, 126-128, 2011.

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8030

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

KITAOKA Kazuyo

Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability

Senior Assistant Professor

NAGAI Makie

Occupational Mental Health

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has published the Japanese version of the Maslach Burnout
Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support thosepeople with mental disabiltiy.

Publications
Originals
8030B001(K.Ohnishi), K.Kitaoka, L.Bowers, D.Stewart, M.VanDerMerwe, M.Nakano, Y.Ohgushi, H.Tanaka, H.Fujii:
Comparison of moral distress and burnout experienced by mental health nurses in Japan and England: a crosssectional questionnaire survey,, Journal of Japan Health Medicine Association, 20:73-86, 2011.

8030B002

M.Nagai, Y.Morikawa, K.Kitaoka, K.Nakamura, M.Sakurai, M.Nishijo, Y.Hamazaki, S.Maruzeni, H.Nakagawa:
Effects of fatigue on immune function in nurses performing shift work, J. Occup. Health, 53:312-319, 2011.

Presentations at Conference
International Conference (Presentations)
8030I001(S.Kendall), L.Bloomfield, J.Appleton, K.Kitaoka: The effects of group based community support for parents inJapan and the UK, 10th International Family Nursing Conference, (Kyoto, '11.06).

8030I002

K.Kitaoka, H.Moto, N.Nakai, M.Mori: The effects of 123 Magic parenting support program, 2nd Japan-Korea Joint
Conference on Community Health Nursing, (Kobe, '11.07).

8030I003

M.Nagai, Y.Morikawa, K.Kitaoka, H.Nakagawa: A cross-sectional study of stress coping among new employees inJapan, The 2nd Japan-Korea Joint Conference on Community Health Nursing, (Kobe, '11.07).

8030I004

K.Kitaoka, Y.Morikawa, H.Nakagawa: Burnout and stress coping styles among Japanese psychiatric nurses, 17th
International Network for Psychiatric Nursing Research Conference, (Oxford, '11.09).

8030I005(K.Ohnishi), K.Kitaoka, J.Nakahara, M.Nagai: Relationships between moral distress and moral sensitivity
experienced by Japanese psychiatric nurses, 17th International Network for Psychiatric Nursing Research
Conference, (Oxford, '11.09).

- 92 -

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring

Senior Assistant Professor

UCHIDA Maki

Cancer Nursing, Terminal Care

Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease

Keywords of Research
Nephrology Nursing, Transplant Nursing, Cronic Disease Nursing, Terminal Care, Cancer Nursing, Nursing Ethics, Woundcare, Stoma care, Continence care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001(S.Iizaka), J.Sugama, G.Nakagami, T.Kaitani, A.Naito, H.Koyanagi, J.Matsuo, T.Kadono, C.Konya, H.Sanada:
Concurrent validation and reliability of digital image analysis of granulation tissue color for clinical pressure ulcers,
Wound Repair. Regen., 19:455-463, 2011.

8040B002(J.Matsuo), J.Sugama, H.Sanada, M.Okuwa, T.Nakatani, C.Konya, J.Sakamoto: Development and validity of a newmodel for assessing pressure redistribution properties of support surfaces, J. Tissue. Viability, 20:55-66, 2011.

8040B003(S.Iizaka), H.Sanada, G.Nakagami, H.Koyanagi, C.Konya, J.Sugama: Quantitative estimation of exudate volume forfull-thickness pressure ulcers: the ESTimation method, J. Wound Care, 20:453-463, 2011.

8040B004(M.Ueta), J.Sugama, C.Konya, J.Matsuo, M.Matsumoto, K.Yabunaka, T.Nakatani, K.Tabata: Use of ultrasound inassessment of necrotic tissue in pressure ulcers with adjacent undermining, J. Wound Care, 20:503-510, 2011.

8040B005(J.Sugama), Y.Shigeta, S.Fukuda, J.Matsuo, A.Kitagawa, C.Konya, E.Murasawa, M.Sedo, M.Okada, N.Matsuoka:
Skin physiology and skin manifestations and relationship to degree of obesity in Japanese subjects aged between 20
and 59 years, J. So. Nurs. Pract., 23:24-29, 2011 (in Japanese) .

8040B007(K.Kimori), J.Sugama, T.Nakatani, S.Fukuda, T.Miyati, C.Konya, M.Okuwa, H.Sanada: Investigation of invisible
peripheral veins for certain and safe venipuncture in catheter placement: Non-invasive measurement of width,
depth, and skin color, Japanese Journal of Nursing Art and Science, 10:103-110, 2011 (in Japanese) .

8040B008(S.Iizaka), G.Nakagami, A.Naito, H.Koyanagai, J.Matsuo, C.Konya, J.Sugama, H.Sanada: Development of analgorithm to quantitatively estimate wound fluid volume for full-thickness pressure ulcers, J. Jpn. WOCM, 15:231238, 2011 (in Japanese) .

- 93 -

Presentations at Conference
International Conference (Presentations)
8040I001(S.Iizaka), G.Nakagami, T.Kaitani, A.Naito, C.Konya, J.Sugama, H.Sanada: Predictive validity of granulation tissue
color by digital image analysis for pressure ulcer healing in a prospective cohort study, 21st Conference of theEuropean Wound Management Association, (Brussels, '11.05).

8040I002(J.Matsuo), J.Sugama, M.Okuwa, C.Konya, H.Sanada: Effects on air mattress pressure redistribution caused bydifferences in bed making, 21st Conference of the European Wound Management Association, (Brussels, '11.05).

8040I003

E.Hirayama, M.Kanaya, M.Koda: A research on the living conditions of and support for elderly citizens living alone
during a disaster recovery period-Interviewing elderly citizens who continue to live alone in the disaster zone after
the Noto earthquake-, 1st NUS-NUH International Nursing Conference, (Republic of Singapore, '11.11)，Alice Lee
Centre for Nursing Studies National University of Singapole, 151, 2011.

- 94 -

8050

Elderly Nursing

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKAYAMA Naoko

community/elderly unrsing science

Senior Assistant Professor

KOIZUMI Yumi

community/elderly unrsing science

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

Keywords of Researchgerontological nursing, influenza infection, influenza vaccine, long-term care facilities, taktil care, care worker, medical
practice, sputum suction, tube feeding

Outline of Research
Survey of influenza infection and vaccination status for elderly in long-term care facilities, Validation of the Effect of Tactile
care, medical practice education for care workers

Publications
Originals
8050B001

L.Zeng, R.Chen, K.Ishigami, M.Atsumi, Y.Koizumi, K.Sato, O.Iritani, M.Okuro, S.Morimoto: Association between
human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility,
Hypertens. Res., 34:474-478, 2011.

- 95 -

8060

Child Nursing

Faculty
Title

Name

Associate Professor

MIYAUCHI Tamaki

Assistant Professor

TERAI Takahiro

Field of Specialization
Caring for Children with Chronic illness, Family Nursing in Child ＆Maternal Health Care
Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment

Outline of Research・Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
・Study of the efficacy of a support program for families with a young child with a developmental disorder・Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
・Study of the system for carrying out abuse prevention

Publications
Originals
8060B001(M.Yoshimoto), A.Mimura, K.Otaguro, T.Terai: Parent's Desires after Their Children Died －Through theInterview with Mothers after the Loss of Children－, Journal of Japanese Society of Pediatric Oncology Nursing,
6:26-33, 2011 (in Japanese) .

- 96 -

8070

Maternity Nursing and Midwifery

Title

Name

Field of Specialization

Professor

OCHIAI Fumie

Maternity Health, Child Health, Midwifery

Associate Professor

SASANO Kyoko

Crinical nursing, Nursing education

Assistant Professor

TSUBOMOTO Takiko Maternity Nursing

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing

Assistant Professor

YORITSUNE Kaoru

Life development nursing

Faculty

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

- 97 -

8080

Community Nursing

Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Senior Assistant Professor

SAKURAI Shihomi

Community Health Nursin

Senior Assistant Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, activity of cmmunity organization, Nonsmoking education, School hygiene, Industrial health

Outline of Research
The community nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, and health maintenance.

Publications
Originals
8080B001

M.Nagai, Y.Morikawa, K.Kitaoka, K.Nakamura, M.Sakurai, M.Nishijo, Y.Hamazaki, S.Maruzeni, H.Nakagawa:
Effects of fatigue on immune function in nurses performing shift work, J. Occup. Health, 53:312-319, 2011.

8080B002

Y.Hamazaki, Y.Morikawa, K.Nakamura, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: The effects of sleep duration on the incidence of cardiovascular events among middle-aged maleworkers in Japan, Scand. J. Work Environ. Health, 37:411-417, 2011.

8080B003(E.Kishi), S.Yoshioka, S.Nomura, M.Konagaya, Y.Hamazaki, J.Yonezawa, Y.Nojiri, Y.Mochizuki: Cases of elder
self-neglect involving specialists and their counter-measures, Journal of the Japan Academy for the Prevention ofElder Abuse, 7:125-138, 2011 (in Japanese) .

8080B004

Y.Hamazaki, E.Kishi, S.Nomura, Y.Nijiri, S.Yosioka, M.Konagaya, Y.Mochizuki, J.Yonezawa: Self-neglect
intervention methods and the dilemmas and difficulties faced by professionals at a community comprehensive
support center, Journal of Japan Academy of Home Care., 15:26-34, 2011 (in Japanese) .

Short Communications
8080E001

Y.Hamazaki: Investigation of what the nursing students have learnt from the narrative of intractable disease patientin the participating class－in close cooperation between university and 'the project of enlightenment and diffusionof living support for intractable diseasa patients' by intractable disease counseling and support centre－, J. J.
Intrac. Ill. Nurs., 15:199-207, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8080I001

S.Sakurai, M.Hirai: Health conditions of family caregivers of Alzheimer patients with no or modest gait
disturbances, 10th International Family Nursing Conference, (Kyoto, '11.06).

- 98 -

8080I002

Y.Hamazaki, M.Nagai: Investigation into needs about health of the functionally independent elderly, 1st GCQHR
congress, (Seoul, Korea, '11.06).

8080I003

Y.Hamazaki, Y.Morikawa, K.Nakamura, A.Yonekura, H.Nakagawa: Relationship between participation in asecondary screening for identifying frail elderly and new onset of need for care among the elderly in a rural town,
Japan, 2st Japan Korea joint Conference on Community Health Nursing, (Kobe, '11.07).

- 99 -

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

KATO Kinko

Home Care Nursing, Public Health Nursing, Psychiatric Mental
Health Nursing in Community

Associate Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
support

Keywords of Research
Psychiatric Disorder, Community besed Workshop, "Recoverry"consept, psychatric service, Public health nursing
home healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced "Recoverry"consept, prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B001(T.Komatsu), S.Maeda, T.Takiuti: Effectiveness of workshop on infection control of home-use mechanicalventilation for home-visiting nurses, Japanese Journal of Environmental Infections, 26:41-48, 2011 (in Japanese) .

Others
8090F001

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

8090F002

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

8090F003

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

- 100 -

8095

Comprehensive Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing, Paliative Care, Chronic
Disease Nursing

Keywords of Researchnephrology, nursing, chronic kidney disease, hemodialysis
nursing, cancer survivors, care development
nursing, live donor, transplants

Outline of Research
Development of A Care for Cancer Survivors
Development of A Care for Live Donor for Transplants
Development of A Care for Patients under Chronic Kidney Disease or Hemodialysis

Presentations at Conference
International Conference (Presentations)
8095I001

S.Tamura: Initial Development of a Care System for Living Donors, Based on Experience Perception by Donors in
Kidney Transplants, World Academy of Nursng Science 2nd International Nursing Research Conference, (Cancun,
Mexico, '11.07)，Sigma Theta Tau International 22nd International Nursing Research Congress, 60, 2011.

- 101 -

8100

Medical Sciences and Clinical Medicine

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

OKADA Masato

Peripheral nerve surgery, Trauma

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Associate Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Associate Professor

HONDA Ryumon

Environment and health, Epidemiology

Associate Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001

T.Ishibashi, N.Nishizawa, M.Nakamoto, F.Abe, H.Liu, J.Yoshida, T.Kawada, M.Nishio: Differrent disappearance
rates of plasma nitrite (NO2-) contribute to apparent steady-state arterio-venous differences in anesthetizedanimals, Biol.Pharm.Bull., 34:528-537, 2011.

8100B002

P.T.Tai, M.Nishijo, T.Kido, H.Nakagawa, S.Maruzeni, R.Naganuma, N.T.N.Anh, Y.Morikawa, H.V.Luong,
T.H.Anh, N.N.Hung, L.K.Son, K.Tawara, H.Nishijo: Dioxin concentrations in breast milk of Vietnamese nursing
mothers: a survey four decades after the herbicide spraying, Environ. Sci. Technol., 45:6625-6632, 2011.

8100B003

T.Ishibashi, T.Miwa, N.Nishizawa, I.Shinkawa, J.Yoshida, T.Kawada, M.Nishio: Role of plasma S-nitrosothiols in
regulation of blood pressure in anesthetized rabbits with special references to hypotensive effects of acetylcholine
and nitrovasodilators, Biol.Pharm.Bull., 34:1307-1313, 2011.

8100B004

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Association between long working hours and sleep problems in white-collar workers, J. Sleep. Res.,
20:110-116, 2011.

8100B005

M.Nagai, Y.Morikawa, K.Kitaoka, K.Nakamura, M.Sakurai, M.Nishijo, Y.Hamazaki, S.Maruzeni, H.Nakagawa:
Effects of fatigue on immune function in nurses performing shift work, J. Occup. Health, 53:312-319, 2011.

- 102 -

8100B006

Y.Hamazaki, Y.Morikawa, K.Nakamura, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: The effects of sleep duration on the incidence of cardiovascular events among middle-aged maleworkers in Japan, Scand. J. Work Environ. Health, 37:411-417, 2011.

8100B007(The Emerging Risk Factors Collaboration), D.Wormser, S.Kaptoge, E.A.Di, E.Angelantonio, AM.Wood,
L.Pennells, A.Thompson, N.Sarwar, JR.Kizer, DA.Lawlor, BG.Nordestgaard, P.Ridker, V.Salomaa, J.Stevens,
M.Woodward, N.Sattar, R.Collins, SG.Thompson, G.Whitlock, J.Danesh, H.Nakagawa, M.Sakurai, K.Nakamura,
Y.Morikawa: Separate and combined associations of body-mass index and abdominal adiposity with cardiovasculardisease: collaborative analysis of 58 prospective studies, Lancet, 377:1085-1095, 2011.

8100B008

W.Zhang, T.Shibamoto, Y.Kurata, H.Kohno: Effects of β-adrenoceptor antagonists on anaphylactic hypotension
in conscious, Eur. J. Pharmacol., 650:303-308, 2011.

8100B009(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: High cadmium
exposure in Mae Sot’s population is associated with high anemia prevalence, Thai J. Toxicology, 26:29-43, 2011.

8100B010

Q.Li, M.Nishijo, H.Nakagawa, Y.Morikawa, M.Sakurai, K.Nakamura, T.Kido, K.Nogawa, M.Dai: Relationshipbetween urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study inJapan, Chin. Med. J., 124:3504-3509, 2011.

8100B011

M.Okada, M.Akagawa, S.Kaneko, K.Hiromura, H.Maeoka, T.Matsumoto: Clinical results of tongue type, Sanders
type 2 fractures of the calcaneus treated by percutaneous osteosynthesis, The Journal of the Japanese Society for
Surgery of the Foot., 32:128-132, 2011 (in Japanese) .

8100B012

M.Nishijo, K.Tawara, T.Seto, Y.Morikawa, R.Naganuma, T.Kido, A.Nguen Thi Nguyet, H.Nakagawa: Relationships
between food intake and dioxin concentrations in breast milk of motehrs in Ishikawa prefecture, Japan, Hokuriku
Japanese Journal of Public Health., 38:1-8, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8100I001

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki: Acuteocular damage threshold of 60 GHz millimeter-wave band exposure, 10th International Conference European
Bioelectromagnetics Association, (Rome, '11.02).

8100I002(K.Nagai), Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, Y.Kawakami, K.Sasaki, H.Sasaki, F.Jonasson: Evaluationof crystalline lens waterclefts by image analysis Reykjavik Eye Study, The Association for Research in Vision andOphthalmology, (Florida, '11.05).

8100I003

M.Kojima, S.Yamaguchi, T.Okuno, Y.Ishiba, K.Sasaki, H.Sasaki: Investigation of the mechanism of near-infraredinduced cataract, The Association for Research in Vision and Ophthalmology, (Florida, '11.05).

8100I004

Y.Morikawa, M.Sakurai, K.Nakamura, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Sift work and heavy drinking,
Biological mechanisms,recovery and risk management in the 24th society, (Stockholm, '11.07).

8100I005

Y.Hamazaki, Y.Morikawa, K.Nakamura, A.Yonekura, H.Nakagawa: Relationship between participation in asecondary screening for identifying frail elderly and new onset of need for care among the elderly in a rural town,
Japan, 2st Japan Korea joint Conference on Community Health Nursing, (Kobe, '11.07).

8100I006(A.Koike), Y.Suzuki, M.Kojima, T.Sakai, K.Wakw, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki: An investigation of thehest transport mechanism under the millimeter -wave exposure considering the convection in the anterior chamberof rabbiy's eye, XXX URSI General Assembly and Scientific Symposum of International union of Radio Science,(Istanbul, '11.08).

8100I007

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K/Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki:
Investigation of acute ocular in jury threshold by 76 Ghz band exposure in rabbits, XXX URSI General Assemblyand Scientific Symposum of International union of Radio Science, (Istanbul, '11.08).

8100I008

K.Kitaoka, Y.Morikawa, H.Nakagawa: Burnout and stress coping styles among Japanese psychiatric nurses, 17th
International Network for Psychiatric Nursing Research Conference, (Oxford, '11.09).

- 103 -

- 104 -Liberal Arts

0040Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

Associate Professor

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex

Associate Professor

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Keywords of Researchpiriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording

Outline of Research
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: I sutdy physics education for a medical student. 1.A computer support physics learning system. 2.Developmentof An experimental device. 3.University lectures on physics for beginners.

- 105 -

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

- 106 -

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

Professor

HORI Isao

Development of ascidians

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell, lectin, galectin, β-galactoside, Xenopus, development, placenta, trophoblast

Outline of Research
１）Functional analysis of Galectins, a family of ・-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
２）Electron microscopic analysis of the mechanisms of regeneration of planarians.

Publications
Reviews
0060C001

E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta: Effects of melanocortins on fetal development, Congenit.
Anom. (Kyoto), 51:47-54, 2011.

Presentations at Conference
International Conference (Presentations)
0060I001

E.Simamura, H.Shimada, H.Shoji, H.Otani, T.Hatta: Maternal-placental-fetal leukemia inhibitory factor signal
pathway contributes stage-specific differentiation from fetal neural stem/progenitor cells to astrocytes, Society for
Neuroscience 2011, (Washington, '11.11).

0060I002

T.Hatta, H.Shimada, E.Simamura, H.Shoji, N.Higashi: Leukemia inhibitory factor induces expression of insulin-likegrowth factor 1 and 2 in the forebrain of rat fetuses via maternal-fetal leukemia inhibitory factor signal pathway,
Society for Neuroscience 2011, (Washington, '11.11).

- 107 -

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

Associate Professor

UEDA Fumio

Physical strength and a study about the athletic capability, A
basketball competition

Senior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program, improvement of physical fitness,
physical fitness, exercise prescription, soccer

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.
Tsuda : Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition, ourresearch focuses on improvememt of physical fitness through soccre for dhildren taing physical education in school.

- 108 -

0010

Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKEDA Koichi

Philosophy, History of logic

Keywords of Research
logic, metaphysics, form, content, predicate, category, deduction, induction, matter, being, substance, definion

Outline of Research
It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is a organon ofscience. However, his logic is the system where reasonings are dependent on the contents of propositions, while modern
formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which are contents oflogic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

Publications
Originals
0010B001

Koichi Takeda: The third interpretation on Aristotle's syllogisms, Mem. Lib. Kanazawa Med. Univ., 39：1-12, 2011
(in Japanese) .

- 109 -

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field- 110 -

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

IKENAKA Masami

EnglishKeywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical English

Outline of Research
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the
English found in medical articles to determine the most commonly used
words, forms and structures.

Publications
Originals
0070B001

Steven Burke: English-through-movies course:Will it english study motivation?, Mem. Lib. Kanazawa Med. Univ.,
39：13-18, 2011.

Presentations at Conference
International Conference (Presentations)
0070I001(E.Donna), Y.Shibuya, A.Suemitsu: American English Rhythm, 2011 Symposium on Modeling of Speech and AudioVisual Mechanism, (Kanazawa, '11.02).

0070I002(E.Donna), Y.Shibuya, A.Suemitsu: Rhythm & Emphasis in American English : Comparison of native & non-native
speakers’ productions, 9th international Seminar on Speech Production (ISSP), (Canada, '11.06).

- 111 -

0070I003(E.Donna), Y.Shibuya, A.Suemitsu: Electromagnetic articulographic (EMA) study of English thythm asa producedby native and non-native speakers., Acoustica societh of A,erica meeting, (San Digo, '11.10).

0070I004(E.Donna), A.Suemitsu, Y.Shibuya, S.Lee, Y.Tanaka: Comparative electromagnetic articulographic study of English
rhythm as produced bynative and non-native speakers, 162nd Acoustical Society of America Meeting, (San Diego,'11.11).

- 112 -

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

Publications
Others0080F001

Munehiro.Kouchi: Wilhelm Mommsen : Die politischen anschauungen Goethes(5), Mem. Lib. Kanazawa Med. Univ.,
39：19-40, 2011 (in Japanese) .

- 113 -

- 114 -University Hospital

0690Department of Endoscopy

Faculty
Title

Name

Professor

Field of Specialization

Diagnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus, gastro-intestine, colon, liver & bileduct
URASHIMA Sachio
disease. Endoscopical treatment of its disease,especially, superficial
type esophageal cancer,early gastric cancer,early colon cancer
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopical
KITAKATA Hidekazu treatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine,colon, disease.Endoscopical
KAWAURA Kentreatment of its disease,especially,superficial type esophageal
cancer,early gastric cancer,early colon cancer.
Diagnosis for esophagus,gastro-intestine, colon, disease.Endoscopical
HAMADA Kazu
treatment of its disease,especially,superficial type esophageal cancer,
early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
ITO Tohru

Associate Professor

Senior Assistant Professor

Senior Assistant Professor

Assistant Professor

Assistant Professor

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Presentations at Conference
International Conference (Presentations)
0690I001

T.Ito, H.Kitakata, S.Kinami, K.Kawaura, T.Kosaka: Endoscopic full-thickness resec-tion for sentinel node negative
submucosal invasive gastric can-cer:fundamental experience in a procine model, UEGW2011, (Stockholm, '11.10).

- 115 -

0620

Department of Pathology

Faculty
Title

Name

Field of Specialization

Professor (Additional Post)

MINATO Hiroshi

Anatomical pathology, Laboratory medicine, Pathological study of
pulmonary and mediastinal lesion, Pathological study of head & necktumor

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Outline of Research
1.Anatomical pathology, Laboratory medicine, Pathological study of pulmonary and mediastinal lesion, Pathological study ofhead & neck tumor.
2.cellular pathology.
3.molecular pathology.

Publications
Case Reports
0620D001

E.Kinoshita, N.Kurose, H.Minato, T.Nojima, Y.Nakano: Clear cell adenocarcinoma coexisting with squamous cell
carcinoma in situ of the uterine cervix-A case report-, J. Jpn. Soc. Clin. Cytol., 50:132-133, 2011 (inJapanese) .

0620D002

I.Chikazawa, K.Miyazawa, T.Tanaka, K.Suzuki, A.Nakagawa, N.Kurose: Composite pheochromocytoma withganglioneuroma in the adrenal gland: A case report, J. Kanazawa. Med. Univ., 36:83-85, 2011 (in Japanese) .

Others
0620F001

H.Minato, T.Nojima, M.Nakano, M.Yamazaki: Safety management in pathology laboratory: from specimen handlingto confirmation of reports, Rinsho Byori, 59:299-304, 2011 (in Japanese) .

- 116 -

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

Assistant Professor

SAITO Takashi

Treatment for metabolic syndrome

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer

Presentations at Conference
International Conference (Presentations)
0640I001

H.Shiroeda, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Saito, T.Fukuyama, N.Hayashi,
T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Shibata, T.Arisawa: Effects of -1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,on dap-kinase hypermenthylation in human gastricmucosa, DDW2011(AGA), (Chicago, '11.05).

0640I002

M.Tsuchishima, J.George, H.Shiroeda, T.Saito, T.Arisawa, M.Tsutsumi: Mechanism of the pathogenesis ofhepatocellular carcinoma during chronic administration of ethanol in mice, AASLD2011, (San Francisco, '11.11).

- 117 -

0700

Multidisciplinary Cancer Center

Title

Name

Field of Specialization

Professor (Additional Post)

TANAKA Tatsuro

Urology

Professor (Additional Post)

TSUJI Hiroyuki

Head & Neck Surgery

MATOBA Munetaka

Radiation Oncology

MASAKI Yasufumi

Hematology/ Oncology

OMOTE Kazuhiko

Surgical treatment of gastric cancer

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

TSUCHIHARA
Katsumaclinical respiratory medicine, lung cancer

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease

Faculty

Associate Professor(Additional Post)
Associate Professor(Additional Post)
Associate Professor(Additional Post)
Senior Assistant Professor(Additional Post)
Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

Keywords of Researchout patient chmotherapy, clinical investigation, biomarker, multidisciplinary cancer

Outline of Research
Our main task is outpatient chemotherapy, which is requested by other Departments of the hospital. We are also involvedin clinical trials on chemotherapy, and in translational research using clinical samples such as blood and urine of patients.

Publications
Originals
0700B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

0700B002

T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara: Efficacy and safety of bortezomib plus dexamethasone therapy forrefractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence ofgastrointestinal adverse events, Anticancer Res., 31:2297-2302, 2011.

0700B003

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

0700B004

T.Shimasaki, K.Miyazawa, M.Moriyama, T.Tanaka, I.Sato, N.Nakaya, H.Nakajima, A.Kubo, K.Suzuki, Y.Motoo:
Combination chemotherapy of docetaxel and uft against hormone refractory prostate cancer, Acta Urol. Jpn.,
57:163-166, 2011 (in Japanese) .

- 118 -

Case Reports
0700D002

N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo: A Case of primary cardiac
angiosarcoma associated with cardiac tamponade, Cancer & chemotherapy., 38:1353-1355, 2011 (in Japanese) .

Others
0700F011

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

0700F012

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

0700F013

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
0700H001

Y.Motoo: Chemotherapy for pancreatic cancer: molecular analysis and clinical application, Asian Oncology Summit
2011, (Hong Kong SAR, '11.04).

0700H002(K.Ogawa), M.Ogawa, Y.Motoo: Kampo Therapy for Cancer Care: Significance as Supportive Measure, 1stInternational Symposium for Japanese Kanpo Medicine, (Munich, '11.11).

International Conference (Presentations)
0700I001

Y.Motoo: Proposal of comparative analysis of herbal medicines among CJK and alignment of the ICTM Herbal
Interventions with other international initiatives, WHO ICTM TAG Classification of Interventions, (Hong Kong
SAR, China, '11.04).

0700I002

Y.Motoo: Japanese viewpoint of ISO/TC249, The Second Plenary Meeting of ISO/TC249, (The Hague, theNetherlands, '11.05).

0700I003

M.Nakamura, T.Arisawa, T.Shibata, T.Tahara, M.Okubo, H.Shiroeda, T.Fukuyama, K.Ozaki, T.Otsuka, I.Hirata:
Comparison of cost-effectiveness of three treatments(Rabeprazole with rebamipide combination
therapy;lansoprazole with rebamipide combination therapy;raberazole monotherapy)for gastric ulcers post-ESD,
DDW2011（ASGE), (Chicago, '11.05).

0700I004

H.Shiroeda, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Saito, T.Fukuyama, N.Hayashi,
T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Shibata, T.Arisawa: Effects of -1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,on dap-kinase hypermenthylation in human gastricmucosa, DDW2011(AGA), (Chicago, '11.05).

0700I005

M.Nakamura, T.Arisawa, T.Shibata, T.Tahara, M.Okubo, H.Shiroeda, T.Fukuyama, K.Ozaki, T.Otsuka,
Y.Takakuwa, M.Kuroda, I.Hirata: Prospective study of collagenous colitis onset associated with long-term
administration of proton pump inhibitors, DDW2011(ASGE), (Chicago, '11.05).

0700I006

T.Fukuyama, T.Tahara, M.Nakamura, H.Yamada, T.Nomura, R.Hayashi, T.Otsuka, H.Yano, K.Ozaki, H.Shiroeda,
M.Tsuchishima, M.Tsutsumi, T.Shibata, T.Arisawa: The pre-microRNA 325,targeting Slc6a4 3'-Utr,gene
polymorphism is closely associated with the risk of functional dyspesia in Japan, DDW2011(AGA), (Chicago,'11.05).

- 119 -

0700I007

K.Ozaki, T.Tahara, M.Nakamura, T.Fukuyama, T.Otsuka, M.Okubo, T.Shibata, T.Arisawa: The-1018 G>apolymorphism of HRH2 gene,coding histamine H2 receptor,affects the susceptibility to the gastric carcinogenesis
in Japan, DDW2011(AGA), (Chicago, '11.05).

0700I008

T.Arisawa, T.Tahara, M.Nakamura, T.Fukuyama, T.Otsuka, H.Shiroeda, M.Okubo, T.Shibata: The-449 C>Gpolymorphism of NFKVB1 gene,coding nuclear factor-kappa B,is associated with the susceptibility to the gastriccarcinogenesis in Japan, DDW2011(AGA), (Chicago, '11.05).

0700I009

Y.Motoo: Evaluation of Japanese clinical practice guidelines based on Kampo descriptions, Guidelines International
Network Conference 2011, (Seoul, Korea, '11.08).

0700I010

Y.Motoo: Pancreatic cancer: experimental sensitization to gemcitabine and patient care with traditional Japanese
medicine, International Conference on Cancer Prevention, (Seoul, Korea, '11.08).

0700I011

H.Nakajima, T.Minamoto, Y.Motoo: HITS(FAM107B): Novel heat-shock induced protein as a maker for cancer
progression and diagnosis, 16th World Congress on Advances in Oncology and 14th International Symposium on
Molecular Medicine, (Rhodes Island, Greece, '11.10).

0700I012

J.George, T.Fukuyama, N.Hayashi, K.Ozaki, H.Shiroeda, T.Arisawa, M.Tsutsumi: Oxxasional alcohol intake
promotes nonalcoholic steatohepatitis in obese rats, ALPD2011, (Fukuoka, '11.10).

0700I013

Y.Motoo, I.Arai, K.Tsutani: Evidence Reports on Kampo Treatment (EKAT), The First International Symposiumfor Japanese Kampo Medicine, (Munich, Germany, '11.11).

0700I014

N.Nakaya, Y.Ishigaki, Q.Bian, S.Ma, T.Shimasaki, H.Nakajima, Y.Motoo: Molecular mechanisms of TP531NP1 in
the gemcitabine sensitivity, The International Pancreatic Research Forum 2011, (Osaka, '11.11).

0700I015

Y.Motoo, I.Arai, T.Hakamatsuka: Japanese viewpoint on ICTM Interventions, Informal Consultation on
Interventions Modeling, (Geneva, Switzerland, '11.12).

- 120 -

0670

Lifestyle-related Diseases Center

Title

Name

Field of Specialization

Professor

MATSUI Shinobu

Clinical cardiology

Faculty

Physical physiology(The exercise testing and prescription from thephysiological and biochemical research), Effects of the anemia on thephysical activitiy, Exercise therapy for the lifestyle-related disease,
Training for health Medical Education
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning

Professor (Additional Post)

TAMURA Nobuki

Professor (Additional Post)

HORI Ariyuki

Associate Professor

ASAJI Takayoshi

Heart failure

Associate Professor(Additional Post)

ITO Tomohiko

Endocrinology

Senior Assistant Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology

NAKANISHI Yumiko

Preventive medicine

KITADA Munehiro

diabetes, hypertension

Assistant Professor

KAMODA Sachikolifestyle-related disease, Preventive medicine

Assistant Professor

HAYASAKI Hisae

lifestyle-related disease

Senior Assistant Professor(Additional Post)
Senior Assistant Professor(Additional Post)

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

Publications
Others
0670F001

M.Terada, J.Fujita, S.Watanabe, M.Kawasaki, H.Tanabe, K.Anzawa, T.Mochizuki: Olecranon bursa with Fusarium

solani infection in an otherwise healthy patient, Mycoses, 54:853-855, 2011.

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0610

Health Management Center

Faculty
Title

Name

Professor

KAWAHARA Hiromu Liver injury and oxidative stress

Professor (Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor (Additional Post)

YASUDA Yukio

evidence-based health care

Professor (Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/ Disease and Medical expenditure

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

Senior Assistant Professor

KUGINUKI Yasuaki

hemodynamics

Assistant Professor

OTA Kiyotaka

Radiology

Assistant Professor

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Associate Professor(Additional Post)
Associate Professor(Additional Post)
Associate Professor(Additional Post)
Associate Professor(Additional Post)

Field of Specialization

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, "stress, dietary habits", "nutrient intake, exercise"

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0610B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

0610B002(Y.Murakami), K.Miura, T.Okamura, H.Ueshima, H.Nakagawa, and for the EPOCH-JAPAN Research Group:
Population attributable numbers and fractions of deaths due to smoking: A pooled analysis of 180,000 Japanese,
Prev. Med., 52:60-65, 2011.

0610B003

K.Usuda, Xi.Zhao, M.Sagawa, M.Matoba, Y.Kuginuki, M.Taniguchi, Y.Ueda, T.Sakuma: Diffusion-weighted imaging
is superior to positron emission tomography in the detection and nodal assessment of lung cancers, Ann. Thorac.
Surg., 91:1689-1695, 2011.

0610B004(D.D.Nhu), T.Kido, N.N.Hung, L.T.H.Thom, R.Naganuma, L.K.Son, S.Honma, S.Maruzeni, M.Nishijo,
H.Nakagawa: Dioxin levels in the breast milk and estradiol and androgen levels in the saliva of Vietnameseprimiparae, Toxicol. Environ. Chem., 93:824-838, 2011.

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0610B005

Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi,
S.Miyazawa, S.Kuwabata: Ionic liquid enables simple and rapid sample preparation of human culturing cells forscanning electron microscope analysis, Microsc. Res. Tech., 74:415-420, 2011.

0610B006

K.Tawara, M.Nishijo, S.Maruzeni, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, D.D.Nhu, N.N.Hung,
L.T.H.Thom: Residual congener pattern of dioxins in human breast milk in southern Vietnam, Chemosphere,
84:979-986, 2011.

0610B007

P.T.Tai, M.Nishijo, T.Kido, H.Nakagawa, S.Maruzeni, R.Naganuma, N.T.N.Anh, Y.Morikawa, H.V.Luong,
T.H.Anh, N.N.Hung, L.K.Son, K.Tawara, H.Nishijo: Dioxin concentrations in breast milk of Vietnamese nursing
mothers: a survey four decades after the herbicide spraying, Environ. Sci. Technol., 45:6625-6632, 2011.

0610B008

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

0610B009

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi,
S.Kuwabata, S.Miyazawa: Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured
human cells by scanning electron microscopy., Microsc. Res. Tech., 74:1104-1108, 2011.

0610B010(J.D.Curb), H.Ueshima, B.L.Rodriguez, Q.He, T.A.Koropatnick, H.Nakagawa, K.Sakata, S.Saitoh, A.Okayama, for
the INTERLIPID study group: Differences in lipoprotein particle subclass distribution for Japanese Americans in
Hawaii and Japanese in Japan: the INTERLIPID study, J. Clin. Lipidol., 5:30-36, 2011.

0610B011

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: Association between long working hours and sleep problems in white-collar workers, J. Sleep. Res.,
20:110-116, 2011.

0610B012

M.Nagai, Y.Morikawa, K.Kitaoka, K.Nakamura, M.Sakurai, M.Nishijo, Y.Hamazaki, S.Maruzeni, H.Nakagawa:
Effects of fatigue on immune function in nurses performing shift work, J. Occup. Health, 53:312-319, 2011.

0610B013

Y.Hamazaki, Y.Morikawa, K.Nakamura, M.Sakurai, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
H.Nakagawa: The effects of sleep duration on the incidence of cardiovascular events among middle-aged maleworkers in Japan, Scand. J. Work Environ. Health, 37:411-417, 2011.

0610B014(M.Sugihara), R.Oka, M.Sakurai, K.Nakamura, T.Moriuchi, S.Miyamoto, Y.Takeda, K.Yagi, M.Yamagishi: Agerelated changes in abdominal fat distribution in Japanese adults in the general population, J. Int. Med., 50:679685, 2011.

0610B015(The Emerging Risk Factors Collaboration), D.Wormser, S.Kaptoge, E.A.Di, E.Angelantonio, AM.Wood,
L.Pennells, A.Thompson, N.Sarwar, JR.Kizer, DA.Lawlor, BG.Nordestgaard, P.Ridker, V.Salomaa, J.Stevens,
M.Woodward, N.Sattar, R.Collins, SG.Thompson, G.Whitlock, J.Danesh, H.Nakagawa, M.Sakurai, K.Nakamura,
Y.Morikawa: Separate and combined associations of body-mass index and abdominal adiposity with cardiovasculardisease: collaborative analysis of 58 prospective studies, Lancet, 377:1085-1095, 2011.

0610B016(A.Kadota), K.Miura, T.Okamura, A.Hozawa, Y.Murakami, A.Fujiyoshi, N.Takashima, T.Hayakawa, Y.Kita,
A.Okayama, Y.Nakamura, H.Ueshima, H.Nakagawa, for the NIPPON DAYA90 research group: Relationship ofmoderate metabolic risk factor clustering to cardiovascular disease mortality in non-lean Japanese:A 15-year
follow-up of NIPPON DATA90, Atherosclerosis, 215:209-213, 2011.

0610B017

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Ke Le: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, Organohalogen Compounds., 73:1745-1748, 2011.

0610B018(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: High cadmium
exposure in Mae Sot’s population is associated with high anemia prevalence, Thai J. Toxicology, 26:29-43, 2011.

0610B019

Q.Li, M.Nishijo, H.Nakagawa, Y.Morikawa, M.Sakurai, K.Nakamura, T.Kido, K.Nogawa, M.Dai: Relationshipbetween urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study inJapan, Chin. Med. J., 124:3504-3509, 2011.

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0610B020

M.Nishijo, K.Tawara, T.Seto, Y.Morikawa, R.Naganuma, T.Kido, A.Nguen Thi Nguyet, H.Nakagawa: Relationships
between food intake and dioxin concentrations in breast milk of motehrs in Ishikawa prefecture, Japan, Hokuriku
Japanese Journal of Public Health., 38:1-8, 2011 (in Japanese) .

0610B021(Y.Ohashi), K.Shimamoto, S.Sato, H.Iso, Y.Kita, A.Kitamura, I.Saito, Y.Kiyohara, H.Kawano, H.Nakagawa,H.Toyoshima, T.Ando, M.Taguri, A.Harada, H.Ueshima: Association of obesity and other cardiovascular risk
factors with stroke The Japan Arteriosclerosis Longitudinal Study- Exisiting Cohorts Combined (JALS-ECC),
Japanese Journal of Public Health., 58:1007-1015, 2011 (in Japanese) .

Short Communications
0610E001(Y.Suwazono), K.Nogawa, M.Uetani, K.Miura, K.Sakata, A.Okayama, H.Ueshima, J.Stamuler, H.Nakagawa:Application of hybrid approach for estimating the benchmark dose of urinary cadmium for adverse renal effects in
the general population of Japan, J. Appl. Toxicol., 31:89-93, 2011.

0610E002(Y.Suwazono), K.Nogawa, M.Uetani, T.Kido, H.Nakagawa: Reassessment of the threshold of urinary cadmium byusing hybrid approach in a cadmium non-pulluted area in Japan, Int. J. Hyg. Environ. Health., 214:175-178, 2011.

0610E003(Y.Suwazono), K.Nogawa, M.Uetani, S.Nakada, T.Kido, H.Nakagawa: Application of the hybrid approach to thebenchmark dose of urinary cadmium as the reference level for renal effects in cadmium polluted and non-polluted
areas in Japan, Environ. Res., 111:312-314, 2011.

Presentations at Conference
International Conference (Presentations)
0610I001(Y.Nakamura), Y.Kiyohara, T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, S.Nagasawa, K.Miura,
H.Ueshima, for the NIPPON DATA Research Group: Saturated Fatty Acids Intake and Coronary Heart Disease
Mortality in Japan: NIPPON DATA90 1990-2005. Nutrition, Physical Activity and Metabolism, Cardiovascular
Disease Epidemiology and Prevention 2011 Scientific Sessions, American Heart Association, (Atlanta, USA,'11.03).

0610I002

Y.Morikawa, M.Sakurai, K.Nakamura, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa: Sift work and heavy drinking,
Biological mechanisms,recovery and risk management in the 24th society, (Stockholm, '11.07).

0610I003(Y.Nakamura), Y.Kiyohara, T.Okamura, A.Higashiyama, M.Watanabe, A.Kadota, S.Nagasawa, K.Miura,
H.Ueshima: Saturated fatty acids intake, polyunsaturated fatty acid intake and coronary heart disease mortality inJapan: NIPPON DATA90 1990-2005., European Society of Cardiology, (Paris, France, '11.08).

0610I004

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Le Ke: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

0610I005

S.Maruzeni, T.Kido, HD.Manh, R.Naganuma, S.Homma, XL.Sun, TT.Pham, M.Nishijo, H.Nakagawa, DD.Mhu,
LTH.Thom, NN.Hung, LK.Son: Impact of dioxin in breast milk on salivary steroid hormone of Vietnameseprimiparas, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

0610I006(T.Kido), R.Naganuma, XL.Sun, S.Maruzeni, HD.Manh, E.Koh, H.Suzuki, M.Nishijo, H.Nakagawa, S.Honma,
DD.Nhu, LTH.Thom, NN.Hung, LK.Son: Comparison of prostate specific antigen leveles in serum between
herbicides/dioxin-hot spot and non-sprayed in Vietnam, 31th International Symposium on Halogenated persistent
Organic Pollutants; Dioxin 2011, (Brussels, '11.08).

0610I007

K.Kitaoka, Y.Morikawa, H.Nakagawa: Burnout and stress coping styles among Japanese psychiatric nurses, 17th
International Network for Psychiatric Nursing Research Conference, (Oxford, '11.09).

0610I008

Y.Kuginuki, H.Tonami, M.Tsutumi, T.Arisawa: Diffusion-weighted MR imaging with navigator -triggered
prospective acquisition correction at 3 T for the assessment of hepatic fibrosis, 97th Radiological Society of North
America, (Chicago, '11.11).

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0610I009(MN.Nguyen), E.Hori, S.Urakawa, TNA.Nguyen, T.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, HA.Tran, T.Ono,
H.Nishijo: Effects of maternal exposure to TCDD on parvalbumin-positive neurons in the limbic system of rat
offspring, The 6th International Conference of Neurons and Brain Diseases, (Toyama, '11.12).

- 125 -

0680

Medical Genetic Center

Faculty
Title
Senior Assistant Professor(Additional Post)
Assistant Professor(Additional Post)

Name

Field of Specialization

ITO Masatsune

child endocrinology

SATO Hitoshi

clinical virology, child infectious disease

Keywords of Research
Medical genetics, Genetic services, Genetic counseling, Genetic testing, DNA diagnosis, Molecular diagnosis, Chromosomal
study

Outline of ResearchStudies and practices of useful methods of genetic concerning
Development of exhaustive and comprehensive genetic testing
Total health care of patients with genetic diseases

Publications
Case Reports
0680D001

K.Nakagawa, S.Kitadate, M.Saito, Y.Fujimoto, K.Kojima, T.Oikawa, K.Oikawa, M.Iguchi, J.Huang, K.Osanai,
H.Toga, K.Araida: Two cases of Birt-Hogg-Dube' syndrome in a family, Jpn. j. clin. Radiol., 56:133-137, 2011 (inJapanese) .

- 126 -

Medical Research Institute7100Department of Life Science

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle, transformation

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Assistant Professor

MURAKAMI Manabu

Pathogeｎｉcity of flavivirus isolated from the field-collectedmosquitoes

Researcher

NAKAMURA Yuka

Molecular and Cellular Biology

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploidcells, polyploidization, triploid/tetraploid/octaploidcells, Meth-A

cells, V79

cells, H-1(ES)cells, RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay,
mutation, DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair,fibroblast growth factor, tumor growth angiogenesis

Outline of Research
1.Study on viral replication and pathogenicity
2.Molecular mechanism of carcinogenesis and metastasis
3.Research on plolyploidization and polyploid cells
4.Analyses of transcription and mRNA decay

Publications
Originals
7100B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

7100B002

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura: Ultraviolet B-induced
expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, Mol. Vis., 17:159169, 2011.

7100B003(H.Suzuki), K.Ozaki, K.Sano, A.H.M.Khurshid Alam, Y.Nakamura, Y.Ishigaki, K.Kawahara, T.Tsukahara:
Comprehensive analysis of alternative splicing and functionality in neuronal differentiation of P19 cells., PLoS
ONE, 6:e16880,1-11, 2011.

7100B004(T.Murayama), C.Bi, Y.Li, Y.Ishigaki, F.Takano, T.Takegami, T.Ohta, H.Sumino, K.Ubukata, T.Takahashi:
Inhibitory effects of statins on cytomegalovirus production in human cells: comprehensive analysis of gene
expression profiles, J. Exp. Clin. Med., 3:40-45, 2011.

- 127 -

7100B005

Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi,
S.Miyazawa, S.Kuwabata: Ionic liquid enables simple and rapid sample preparation of human culturing cells forscanning electron microscope analysis, Microsc. Res. Tech., 74:415-420, 2011.

7100B006(J.F.Guo), K.Higashi, Y.Ueda, Y.Ishigaki, T.Sakuma, M.Oguchi, T.Takegami, Y.Ohta, L.Zhang, K.Xu, H.Nishida,
H.Tonami: VEGF-A and its isoform VEGF121 mRNA expression measured by quantitative real-time RT-PCR:
correlation with F-18 FDG uptake and aggressiveness of lung adenocarcinoma: preliminary study, Ann. Nucl.
Med., 25:29-36, 2011.

7100B007

T.Ikeda, L.Sun, N.Tsuruoka, Y.Ishigaki, Y.Yoshitomi, Y.Yoshitake, H.Yonekura: Hypoxia down-regulates sFlt-1(sVEGFR-1) expression in human microvascular endothelial cells by a mechanism involving mRNA alternative
processing, Biochem. J., 436:399-407, 2011.

7100B008(A.Iwai), T.Takegami, T.Shiozaki, T.Miyazaki: Hepatitis C Virus NS3 Protein Can Activate the Notch-Signaling
Pathway through Binding to a Transcription Factor, SRCAP, PLoS ONE, 6:e20718,1-12, 2011.

7100B009(R.Kurayama), N.Ito, Y.Nishibori, D.Fukuhara, Y.Akimoto, E.Higashihara, Y.Ishigaki, Y.Sai, K.Miyamoto,H.Endou, Y.Kanai, K.Yan: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and thepathogenesis of crescentic glomerulonephritis, Lab. Invest., 91:992-1006, 2011.

7100B010

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

7100B011

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi,
S.Kuwabata, S.Miyazawa: Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured
human cells by scanning electron microscopy., Microsc. Res. Tech., 74:1104-1108, 2011.

7100B012

J.Moriya, R.Chen, J.Yamakawa, K.Sasaki, Y.Ishigaki, T.Takahashi: Resveratrol improves hippocampal atrophy inchronic fatigue mice by enhancing neurogenesis and inhibiting apoptosis of granular cells, Arch. Oral Biol., 34:354359, 2011.

7100B013

K.Fujikawa-Yamamoto, M.Miyagoshi, X.Luo, H.Yamagishi: DNA-unstable decaploid mouse H1 (ES) cells
established from DNA-stable pentaploid H1 (ES) cells polyploidized using demecolcine, Cell Prolif., 44:111-119,
2011.

7100B014

K.Fujikawa-Yamamoto, M.Miyagoshi, X.Luo, H.Yamagishi: Hexaploid H1 (ES) cells established from octaploid H1
cells are as DNA stable as pentaploid H1 cells, Hum. Cell., 24:13-20, 2011.

7100B015

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi, T.Ota: Haploid unit-ploidy transition of tetraploid andoctaploid H1 (ES) cells in long-term culturing, Hum. Cell., 24:78-85, 2011.

Reviews
7100C001

Y.Motoo, T.Shimasaki, Y.Ishigaki, H.Nakajima, K.Kawakami, T.Minamoto: Metabolic disorder, inflammation, andderegulated molecular pathways converging in pancreatic cancer development: Implications for new therapeuticstrategies, Cancers (Basel)., 3:446-460, 2011.

Presentations at Conference
International Conference (Synposium)
7100H001

T.Ikeda, Y.Yoshitomi, Y.Ishigaki, Y.Yoshitake, H.Yonekura: Soluble VEGFR-1 production is down-regulated underhypoxia in human microvascular endothelial cells by a mechanism involving alternative mRNA 3′-end processing,
The Molecular Biology Society of Japan The 11th Spring Symposium International Symposium on Tumor Biology in
Kanazawa, (Kanazawa, '11.05).

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International Conference (Presentations)
7100I001

T.Okuda, Y.Tachi, N.Kawahara, N.Kato, Y.Ishigaki, E.Hatano, Y.Yasuda, T.Matsumoto: Hyaluronidase-4
expression in a rat spinal cord hemisection model, Second Annual Meeting of Cervical Spine Research Society Asia
Pacific Section (CSRS-AP 2011), (Busan, '11.04).

7100I002

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi, X.Luo: Haploid unit-ploidy transition of tetraploid andoctaploid H1(ES) cells in long-term culturing, ISAC XXVI International Congress, (Baltimore, '11.05).

7100I003

T.Ikeda, Y.Yoshitomi, Y.Ishigaki, Y.Yoshitake, H.Yonekura: Hypoxia doun-regulates sFlt-1(sVEGFR-1)
expression in human microvascular endothelial cells by a mechanism involving mRNA alternative processing, 36th
FEBS Congress, (Torino, '11.06).

7100I004

Y.Yoshitake, H.Osada, T.Ikeda, Y.Yoshitomi, Y.Ishigaki, H.sasaki, H.Yonekura: Ultraviolet B-induced expressionof amphiregulin and growth differentiation factor 15 in human lens epithelial cells, 36th FEBS Congress, (Torino,'11.06).

7100I005

T.Takegami, M.Murakami, M.Nukuzuma, Y.Ishigaki: Physiological function of Japanese encephalitis virus protein
NS4a., XV International Congress of Virology, (Sapporo, '11.09).

7100I006

M.Murakami, K. Kamimura, Y.Oikawa, T.Takegami: Isolation and characterization of Japanese encephalitis virus
from mosquitoes in Ishikawa, Japan in 2010, XV International Congress of Virology, (Sapporo, '11.09).

7100I007

N.Nakaya, Y.Ishigaki, Q.Bian, S.Ma, T.Shimasaki, H.Nakajima, Y.Motoo: Molecular mechanisms of TP531NP1 in
the gemcitabine sensitivity, The International Pancreatic Research Forum 2011, (Osaka, '11.11).

7100I008

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Hato, E.Hatano, T.Matsumoto: Does Hyaluronidase-4
digest chondroitin sulfate proteoglycans in a rat spinal cord hemisection model?, Neuroscience 2011, (Washington,'11.11).

- 129 -

7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor

KUHARA Tomiko

Noninvasive metabolome analysis for diagnosis of metabolic disorders
and personalized medicine

Professor (Additional Post)

MATSUI Shinobu

Clinical cardiology

Professor (Additional Post)

DATE Takayasu

Function of protein Kinase, PKU-β/TLK1 and PKU-α/TLK2

Professor (Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine

Senior Assistant Professor(Additional Post)SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Research Associate

MURANO Hidekazu

Cardial histology and immunohistochemistry

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic
glomerulonephritis, anti-aging, AGEs,

heart failure, cardiomyopathy, nerohumoral

epigenetics, clinical oncology, gastroenterology, tumor biology, genetic
congenital

renal failure,factor, autoantibody, cell cycle,

counseling, genetic service, prenatal

diagnosis,

abnormality, karyotype

Outline of Research
1.Heart failure by autoimmune pathway related with G-protein
2.Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
3.The role of AGE in the prevention of lifestyle related disease
4.Clinical research for the diagnosis and treatment of pancreatic cancer
5.Development and clinical application of fetal DNA diagnosis using mother’s blood
6.Genetic diagnosis and analysis of hereditary developmental disability
7.Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Publications
Originals
7200B001(QS.Xia), Y.Ishigaki, X.Zhao, T.Shimasaki, H.Nakajima, H.Nakagawa, T.Takegami, ZH.Chen, Y.Motoo: Human
SMG-1 is involved in gemcitabine-induced primary microRNA-155/BIC up-regulation in human pancreatic cancer
PANC-1 cells, Pancreas, 40:55-60, 2011.

- 130 -

7200B002

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura: Ultraviolet B-induced
expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, Mol. Vis., 17:159169, 2011.

7200B003

Y.Ishigaki, Y.Nakamura, T.Takehara, N.Nemoto, T.Kurihara, H.Koga, H.Nakagawa, T.Takegami, N.Tomosugi,
S.Miyazawa, S.Kuwabata: Ionic liquid enables simple and rapid sample preparation of human culturing cells forscanning electron microscope analysis, Microsc. Res. Tech., 74:415-420, 2011.

7200B004

T.Kuhara, M.Ohse, Y.Inoue, A.J.L.Cooper: A GC/MS-based metabolomic approach for diagnosing citrin
deficiency, Anal. Bioanal. Chem., 400:1881-1894, 2011.

7200B005

T.Kuhara, Y.Inoue, M.Ohse, B.F.Krasnikov, A.J.L.Cooper: Urinary 2-hydroxy-5-oxoproline, the lactam form of
α-ketoglutaramate, is markedly increased in urea cycle disorders, Anal. Bioanal. Chem., 400:1843-1851, 2011.

7200B006(Y.Ishibashi), T.Matsui, M.Takeuchi, S.Yamagishi: Rosuvastatin blocks advanced glycation end products-elicited
reduction of macrophage cholesterol efflux by suppressing NADPH oxidase activity via inhibition of
geranylgeranylation of Rac-1, Horm. Metab. Res., 43: 619-624, 2011.

7200B007

T.Fukushima, T.Nakamura, H.Iwao, A.Nakajima, M.Miki, T.Sato, T.Sakai, T.Sawaki, Y.Fujita, M.Tanaka,
Y.Masaki, H.Nakajima, Y.Motoo, H.Umehara: Efficacy and safety of bortezomib plus dexamethasone therapy forrefractory or relapsed multiple myeloma: once-weekly administration of bortezomib may reduce the incidence ofgastrointestinal adverse events, Anticancer Res., 31:2297-2302, 2011.

7200B008

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Shimasaki, T.Tatsuno, F.Takano, Y.Ueda, Y.Motoo, T.Takegami,
H.Nakagawa, S.Kuwabata, N.Nemoto, N.Tomosugi, S.Miyazawa: Scanning electron microscopy with an ionic liquid
reveals the loss of mitotic protrusions of cells during the epithelial-mesenchymal transition, Microsc. Res. Tech.,
74:1024-1031, 2011.

7200B009

Y.Ishigaki, Y.Nakamura, T.Takehara, T.Kurihara, H.Koga, T.Takegami, H.Nakagawa, N.Nemoto, N.Tomosugi,
S.Kuwabata, S.Miyazawa: Comparative study of hydrophilic and hydrophobic ionic liquids for observing cultured
human cells by scanning electron microscopy., Microsc. Res. Tech., 74:1104-1108, 2011.

7200B010(T.Saheki), K.Inoue, H.Ono, A.Tushima, N.Katsura, M.Yokogawa, Y.Yoshidumi, T.Kuhara, M.Ohse, K.Eto,
T.Kadowaki, D.S.Sinasac, K.Kobayashi: Metabolomic analysis reveals hepatic metabolite perturbations incitrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mice, a model of human citrin
deficiency, Mol. Genet. Metab., 104:492-500, 2011.

7200B011

T.Shimasaki, K.Miyazawa, M.Moriyama, T.Tanaka, I.Sato, N.Nakaya, H.Nakajima, A.Kubo, K.Suzuki, Y.Motoo:
Combination chemotherapy of docetaxel and uft against hormone refractory prostate cancer, Acta Urol. Jpn.,
57:163-166, 2011 (in Japanese) .

Reviews
7200C001

Y.Motoo, T.Seki, K.Tsutani: Traditional Japanese medicine, Kampo: Its history and current status, Chin. J. Integr.
Med., 17:85-87, 2011.

7200C002

Y.Motoo, T.Shimasaki, Y.Ishigaki, H.Nakajima, K.Kawakami, T.Minamoto: Metabolic disorder, inflammation, andderegulated molecular pathways converging in pancreatic cancer development: Implications for new therapeuticstrategies, Cancers (Basel)., 3:446-460, 2011.

Case Reports
7200D002

N.Nakaya, I.Sato, T.Shimasaki, H.Nakajima, N.Kurose, T.Nojima, Y.Motoo: A Case of primary cardiac
angiosarcoma associated with cardiac tamponade, Cancer & chemotherapy., 38:1353-1355, 2011 (in Japanese) .

Others
7200F001

Y.Inoue, M.Ohse: Prenatal diagnosis of methylmalonic aciduria by measuring methylmalonic acid in dried amniotic
fluid on filter paper using gas chromatography-mass spectrometry, Anal. Bioanal. Chem., 400:1953-1958, 2011.

- 131 -

7200F002(S.Maeda), T.Matsui, M.Takeuchi, S.Yamagishi: Pigment epithelium-derived factor (PEDF) blocks advanced
glycation end products (AGEs)- RAGE-induced suppression of adiponectin mRNA level in adipocytes by inhibiting
NADPH oxidase- mediated oxidative stress generation, Int. J. Cardiol., 152:408-410, 2011.

7200F011

K.Kyuji, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno: The anxiety and types of problems encounteredby homecare patients during an intermittent self-catheterization, Cancer & chemotherapy., 38(supplⅠ): 103-105,
2011 (in Japanese) .

7200F012

Y.Kohno, S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, K.Kyuji: Self purchase of catheter supplies and thehardship associated with urinary homecare patients, Cancer & chemotherapy., 38(supplⅠ):106-108, 2011 (inJapanese) .

7200F013

S.Maeda, M.Moriyama, T.Shimasaki, T.Kanda, Y.Kohno, K.Kyuji: A study of the goods supply system from hospitalto outpatients with intermittent self-catheterization(ISC), Cancer & chemotherapy., 38(supplⅠ):109-111, 2011 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
7200H001

Y.Motoo: Chemotherapy for pancreatic cancer: molecular analysis and clinical application, Asian Oncology Summit
2011, (Hong Kong SAR, '11.04).

International Conference (Presentations)
7200I001

Y.Motoo: Proposal of comparative analysis of herbal medicines among CJK and alignment of the ICTM Herbal
Interventions with other international initiatives, WHO ICTM TAG Classification of Interventions, (Hong Kong
SAR, China, '11.04).

7200I002

Y.Motoo: Japanese viewpoint of ISO/TC249, The Second Plenary Meeting of ISO/TC249, (The Hague, theNetherlands, '11.05).

7200I003

Y.Motoo: Evaluation of Japanese clinical practice guidelines based on Kampo descriptions, Guidelines International
Network Conference 2011, (Seoul, Korea, '11.08).

7200I004

Y.Motoo: Pancreatic cancer: experimental sensitization to gemcitabine and patient care with traditional Japanese
medicine, International Conference on Cancer Prevention, (Seoul, Korea, '11.08).

7200I005

H.Nakajima, T.Minamoto, Y.Motoo: HITS(FAM107B): Novel heat-shock induced protein as a maker for cancer
progression and diagnosis, 16th World Congress on Advances in Oncology and 14th International Symposium on
Molecular Medicine, (Rhodes Island, Greece, '11.10).

7200I006

Y.Motoo, I.Arai, K.Tsutani: Evidence Reports on Kampo Treatment (EKAT), The First International Symposiumfor Japanese Kampo Medicine, (Munich, Germany, '11.11).

7200I007

N.Nakaya, Y.Ishigaki, Q.Bian, S.Ma, T.Shimasaki, H.Nakajima, Y.Motoo: Molecular mechanisms of TP531NP1 in
the gemcitabine sensitivity, The International Pancreatic Research Forum 2011, (Osaka, '11.11).

7200I008

Y.Motoo, I.Arai, T.Hakamatsuka: Japanese viewpoint on ICTM Interventions, Informal Consultation on
Interventions Modeling, (Geneva, Switzerland, '11.12).

- 132 -

7310

Division of HT Research

Faculty
Title

Name

Field of Specialization

Associate Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Researcher

ZHANG Jun

Hepatitis C virus

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
7310B001(D.D.Nhu), T.Kido, N.N.Hung, L.T.H.Thom, R.Naganuma, L.K.Son, S.Honma, S.Maruzeni, M.Nishijo,
H.Nakagawa: Dioxin levels in the breast milk and estradiol and androgen levels in the saliva of Vietnameseprimiparae, Toxicol. Environ. Chem., 93:824-838, 2011.

7310B002

K.Tawara, M.Nishijo, S.Maruzeni, H.Nakagawa, T.Kido, R.Naganuma, H.Suzuki, D.D.Nhu, N.N.Hung,
L.T.H.Thom: Residual congener pattern of dioxins in human breast milk in southern Vietnam, Chemosphere,
84:979-986, 2011.

7310B003

P.T.Tai, M.Nishijo, T.Kido, H.Nakagawa, S.Maruzeni, R.Naganuma, N.T.N.Anh, Y.Morikawa, H.V.Luong,
T.H.Anh, N.N.Hung, L.K.Son, K.Tawara, H.Nishijo: Dioxin concentrations in breast milk of Vietnamese nursing
mothers: a survey four decades after the herbicide spraying, Environ. Sci. Technol., 45:6625-6632, 2011.

7310B004

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Ke Le: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, Organohalogen Compounds., 73:1745-1748, 2011.

7310B005

Q.Li, M.Nishijo, H.Nakagawa, Y.Morikawa, M.Sakurai, K.Nakamura, T.Kido, K.Nogawa, M.Dai: Relationshipbetween urinary cadmium and mortality in habitants of a cadmium-polluted area: a 22-year follow-up study inJapan, Chin. Med. J., 124:3504-3509, 2011.

7310B006(T.Kido), R.Naganuma, XL.Sun, S.Maruzeni, HD.Manh, E.Koh, H.Suzuki, M.Nishijo, H.Nakagawa, S.Honma,
DD.Nhu, LTH.Thom, NN.Hung, LK.Son: Comparison of prostate specific antigen levels in serum between
herbicides/dioxin-hot spot and non-sprayed areas in Vietnam, Organohalogen Compounds., 73:1729-1732, 2011.

7310B007

M.Nishijo, K.Tawara, T.Seto, Y.Morikawa, R.Naganuma, T.Kido, A.Nguen Thi Nguyet, H.Nakagawa: Relationships
between food intake and dioxin concentrations in breast milk of motehrs in Ishikawa prefecture, Japan, Hokuriku
Japanese Journal of Public Health., 38:1-8, 2011 (in Japanese) .

- 133 -

Presentations at Conference
International Conference (Presentations)
7310I001

M.Nishijo, T.Pham-The, NA.Nguen-Thi, S.Maruzeni, H.Nakagawa, H.Nishijo, HA.Tran, L.Hoang-Van, T.Kido,
R.Naganuma, NN.Hung, MH.Nguen, S.Le Ke: Effects of dioxins exposure on infant growth in a hot spot area,
Vietnam, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

7310I002

S.Maruzeni, T.Kido, HD.Manh, R.Naganuma, S.Homma, XL.Sun, TT.Pham, M.Nishijo, H.Nakagawa, DD.Mhu,
LTH.Thom, NN.Hung, LK.Son: Impact of dioxin in breast milk on salivary steroid hormone of Vietnameseprimiparas, 31th International Symposium on Halogenated persistent Organic Pollutants; Dioxin 2011, (Brussels,'11.08).

7310I003(T.Kido), R.Naganuma, XL.Sun, S.Maruzeni, HD.Manh, E.Koh, H.Suzuki, M.Nishijo, H.Nakagawa, S.Honma,
DD.Nhu, LTH.Thom, NN.Hung, LK.Son: Comparison of prostate specific antigen leveles in serum between
herbicides/dioxin-hot spot and non-sprayed in Vietnam, 31th International Symposium on Halogenated persistent
Organic Pollutants; Dioxin 2011, (Brussels, '11.08).

7310I004(MN.Nguyen), E.Hori, S.Urakawa, TNA.Nguyen, T.Pham, M.Nishijo, H.Nakagawa, S.Maruzeni, HA.Tran, T.Ono,
H.Nishijo: Effects of maternal exposure to TCDD on parvalbumin-positive neurons in the limbic system of rat
offspring, The 6th International Conference of Neurons and Brain Diseases, (Toyama, '11.12).

- 134 -

7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor (Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

KAWAKAMI Yutaka

cataract, thyroid ocular

Associate Professor(Additional Post)
Senior Assistant Professor(Additional Post)

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure
specific damages were seen. No one has pointed out the above up to now.

Publications
Originals
7320B001

H.Osada, Y.Yoshitake, T.Ikeda, Y.Ishigaki, T.Takata, N.Tomosugi, H.Sasaki, H.Yonekura: Ultraviolet B-induced
expression of amphiregulin and growth differentiation factor 15 in human lens epithelial cells, Mol. Vis., 17:159169, 2011.

7320B002

Y.Yamashiro, H.Sasaki, N.Ibaraki, K.Nagai, Y.Kawakami, H.Yaguchi, N.Fujita, H.Osada, K.Sasaki: Cyclindependent kinase inhibitor p16 and p21 expression, and cell cycle change in human lens epithelial cell line SRA
01/04 following contact inhibition in normal culture, Ophthalmic Res., 46:38-43, 2011.

7320B003

H.Sasaki, Y.Sakamoto, C.Schnider, N.Fujita, N.Hatsusaka, DH.Sliney, K.Sasaki: UV-B exposure to the eyedepending on solar altitude, Eye Contact Lens, 37:191-195, 2011.

7320B004

H.Yaguchi, T.Ikeda, H.Osada, Y.Yoshitake, H.Sasaki, H.Yonekura: Identification of the COL2A1 mutation inpatients with type I Stickler syndrome using RNA from freshly isolated peripheral white blood cells, Genet. Test.
Mol. Biomarkers, 15:231-237, 2011.

7320B005

M.Fukuda, N.Shibata, H.Osada, Y.Yamashiro, H.Sasaki: Vitreous and aqueous penetration of orally and topicallyadministered moxifloxacin, Ophthalmic Res., 46:113-117, 2011.

7320B006(D.Oyama), Y.Adachi, N.Hatsusaka, T.Kasahara, M.Yumoto, I.Hashimoto, G.Uehara: Evaluation of an IsoscelesTriangle-Coil phantom for magnetoencephalography, IEEE Trans. Magn., 47:3853-3856, 2011.

- 135 -

7320B007(N.Fujii), T.Kawaguchi, H.Sasaki, N.Fujii: Simultaneous stereoinversion and isomerization at the Asp-4 residue in
βB2-crystallin from the aged human eye lenses, Biochemistry, 50:8628-8635, 2011.

7320B009

M.Fukuda, H.Yaguchi, N.Fujita, I.Shibata, H.Osada, N.Shibata, H.Sasaki: Effect of sodium hyaluronate eyedrops
on corneal cells, Journal of the eye., 28:549-552, 2011 (in Japanese) .

7320B010

M.Fukuda, I.Shibata, K.Hagiwara, H.Yaguchi, H.Sasaki: Generic versions of latanoprost ophthalmic solution
evaluated for safety to corneal epithelial cells, Journal of the eye., 28:849-854, 2011 (in Japanese) .

7320B011

N.Mita, N.Hatsusaka, E.Shibata, Y.Sakamoto, H.Osada, I.Shibata, N.Shibata, H.Yaguchi, K.Sasaki, H.Sasaki:
Assessing predictive accuracy of lens transparency property via 10-year follow-up in Japanese, Journal of the eye.,
28:1503-1507, 2011 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
7320I001

H.Sasaki, N.Mita, N.Hatsusaka, E.Shibuya, F.Jonasson, Y.Sakamoto, K.Sasaki: Factors influencing retinal image
contrast -Reykjavik Eye Study, The Association for Research in Vision and Ophthalmology, (Florida, '01.05).

7320I002

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki: Acuteocular damage threshold of 60 GHz millimeter-wave band exposure, 10th International Conference European
Bioelectromagnetics Association, (Rome, '11.02).

7320I003

N.Mita, N.Hatsusaka, E.Shibuya, Y.Sakamoto, N.Yamamoto, H.Sasaki: Aging change of retinal image contrast in
the eyes with transparent lenses of Japanese, The Association for Research in Vision and Ophthalmology, (Florida,'11.05).

7320I004(K.Nagai), Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, Y.Kawakami, K.Sasaki, H.Sasaki, F.Jonasson: Evaluationof crystalline lens waterclefts by image analysis Reykjavik Eye Study, The Association for Research in Vision andOphthalmology, (Florida, '11.05).

7320I005

M.Kojima, S.Yamaguchi, T.Okuno, Y.Ishiba, K.Sasaki, H.Sasaki: Investigation of the mechanism of near-infraredinduced cataract, The Association for Research in Vision and Ophthalmology, (Florida, '11.05).

7320I006

N.Hatsusaka, E.Shibuya, N.Mita, Y.Sakamoto, H.Yaguchi, S.Inagaki, H.Osada, N.Shibata, K.Sasaki, H.Sasaki:
Relationship between 10-year-change in refraction of crystallines lens and aging, The Association for Research in
Vision and Ophthalmology, (Florida, '11.05).

7320I007

M.Fukuda, S.Inagaki, K.Hagiwara, H.Yaguchi, H.Osada, N.Shibata, H.Sasaki: Safety evaluation of feneric versionsof latanoprost ophthalmic solution for corneal epithelial cells, The Association for Research in Vision andOphthalmology, (Florida, '11.05).

7320I008(A.Koike), Y.Suzuki, M.Kojima, T.Sakai, K.Wakw, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki: An investigation of thehest transport mechanism under the millimeter -wave exposure considering the convection in the anterior chamberof rabbiy's eye, XXX URSI General Assembly and Scientific Symposum of International union of Radio Science,(Istanbul, '11.08).

7320I009

M.Kojima, H.Sasaki, K.Sasaki, T.Sakai, K/Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki, M.Taki:
Investigation of acute ocular in jury threshold by 76 Ghz band exposure in rabbits, XXX URSI General Assemblyand Scientific Symposum of International union of Radio Science, (Istanbul, '11.08).

- 136 -

7330

Division of Dermatomycology

Faculty
Title

Name

Field of Specialization

Professor (Additional Post)

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Assistant Professor(Additional Post)

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Books
7330A002

T.Mochizuki, K.Anzawa: Deep mycoses in Japan, World Congress of Dermatology 2011, 393-397, Special Book,
Seoul Korea, 2011.

7330A003

T.Mochizuki, M.Kawasaki, K.Anzawa: Genetic variation of fungus in Asia, World Congress of Dermatology 2011,375-379, Special Book, Seoul Korea, 2011.

Publications
Originals
7330B001(R.Kano), T.Yamada, K.Makimura, M.Kawasaki, T.Mochizuki, H.Kamata, A.Hasegawa: Arthroderma benhamiae(The Teleomorph of Trichophyton mentagrophytes) Mating Type-Specific Genes, Mycopathologia, 171:333-337,
2011.

7330B002

M.Kawasaki, K.Anzawa, T.Ushigami, J.Kawanishi, T.Mochizuki: Multiple gene analyses are necessary tounderstand accurate phylogenetic relationships among Trichophyton Species, Med. Mycol. J., 52:245-254, 2011.

7330B003

K.Anzawa, M.Kawasaki, M.Hironaga, T.Mochizuki: Genetic ｒelationship between Trichophyton mentagrophytesvar. interdigitale and Arthroderma vanbreuseghemii, Med. Mycol. J., 52:223-227, 2011.

7330B004

K.Anzawa, T.Mochizuki, A.Nishibu, H.Ishizaki, K.Kamei, Y.Takahashi, M.Fujihiro, H.Shinoda: Molecularepidemiology of Trichophyton tonsurans strains isolated in Japan between 2006 and 2010 and their susceptibility tooral antimycotics, Jpn. J. Infect. Dis., 64:458-462, 2011.

- 137 -

7330B005

K.Takeda, T.Ushigami, M.Terada, N.Wakamatsu, A.Nishibu, H.Tanabe, M.Yanagimoto, K.Anzawa, M.Kawasaki,
T.Mochizuki, H.Ishizaki: Twenty-three cases of tinea capitis at the Kanazawa Medical University Hospital in thepast 10 years, The Japanese Journal of Dermatology, 121:1057-1061, 2011 (in Japanese) .

Reviews
7330C001

M.Kawasaki: Verificatin of taxonomy of dermatophytes based on mating results and phylogenetic analyses, Med.
Mycol. J., 52:291-295, 2011.

Others
7330F001

M.Terada, J.Fujita, S.Watanabe, M.Kawasaki, H.Tanabe, K.Anzawa, T.Mochizuki: Olecranon bursa with Fusarium

solani infection in an otherwise healthy patient, Mycoses, 54:853-855, 2011.

Presentations at Conference
International Conference (Key Note Lecture)
7330G001

T.Mochizuki: Recent Molecular Approaches for the Epidemiology of Dermatomycoses, 18th Annual meeting of
Korean Society for Medical Mycology, (Seoul, '11.09).

International Conference (Synposium)
7330H001

T.Mochizuki: Recent advances and problems in diagnosis of fungal diseases in dermatology, 13th International
Congress of Mycology, (Sapporo, '11.09).

International Conference (Presentations)
7330I001

M.Hasei, K.Anzawa, M.Kawasaki, H.Tanabe, T.Mochizuki: A case of phaeohyphomycosis caused by exophiala
jeanselmei producing multiple skin lesions, The 22nd World Congress of Dermatology 2011 (WCD 2011), (Korea,'11.05).

- 138 -

Affilated Institution

9050Center for FDD-MB

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine

Researcher

YUDITIYA Purwosunu fetal medicine, DNA medicine

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's
health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology- 139 -

9030

North Noto Institute of Community Medicine

Faculty
Title

Name

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

NOMURA Koji

Geriatrics, Circulation

KITAMURA Kenji

Hip surgery

AKAGAWA Makoto

orthopaedic surgery

Assistant Professor(Additional Post)
Research Doctor(Additional Post)

Field of Specialization

Keywords of Research
The Elderly, Rural Medicine, Medical Needs

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

- 140 -

Himi Municipal Hospital

9100Himi Municipal Hospital.

Faculty
Title

Name

Field of Specialization

Director

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery

Professor

IZUMI Youichi

Hypertension, Endocrinology

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

MATSUKI Nobuo

Health Evaluation，Digestive Surgery，Proctological Surgery

Associate Professor

MIURA Motohiro

Circulatory organs internal medicine

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

YOSHITANI Shinichiro Surgery of colorectal cancer

Associate Professor

KUZAWA Yutaka

Cardio Vascular Surgery

Associate Professor

IKEBUCHI Kimihiro

Orthopedic Surgert

Associate Professor

URATA Kazuhiko

Obstetrics and gynecology

Associate Professor

TAKADA Hisashi

Neuro Surgery

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

YAMASHITA Naohiro Circulatory organs internal medicine

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

IGUCHI Masaharu

Clinical respiratory medicine

Senior Assistant Professor

FUJIKI Takuma

Prediatric nephrology

Senior Assistant Professor

TANAKA Yumiko

Surgery of colorectal cancer

Senior Assistant Professor

HASEGAWA Taisuke Surgery of hepatobiliary diseases

Senior Assistant Professor

KIYOSAWA Jun

Cardio Vascular Surgery

Senior Assistant Professor

AOKI Nobuyuki

Orthopedic Surgery

Senior Assistant Professor

WATANABE Seiji

Dermatology，Dermatomycosis

Senior Assistant Professor

TSUCHIDA Maki

Ophthalmology

Senior Assistant Professor

OHURA Kazuko

Otorhine Laryugology

Assistant Professor

MIZUNO Takuro

regional medicine

Assistant Professor

ASTUMI Hisanari

Diabetes

Assistant Professor

ISHIGAMI Keiichiro

Geriatrics, Dementia

Assistant Professor

KOIKE Rie

Regional Medicine

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Thyroid diseases，Breast diseases

Assistant Professor

ARISAWA Akiko

Orthopaedic Science

Assistant Professor

KUSABA Eizo

neurosurgery.

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Publications
Originals
9100B001

L.Zeng, R.Chen, K.Ishigami, M.Atsumi, Y.Koizumi, K.Sato, O.Iritani, M.Okuro, S.Morimoto: Association between
human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility,
Hypertens. Res., 34:474-478, 2011.

9100B002

M.Matoba, I.Toyota, Y.Kuginuki, H.Tonami, T.Miyazawa, Y.Shimode, H.Tsuji, T.Miwa: Efficacy of diffusionweighted MR imaging and PET/CT for predicting and detecting early response to chemoradiation therapy
squamous cell carcinoma in the head and neck, J. J. M. R. M., 31:115-123, 2011 (in Japanese) .

Case Reports
9100D001

A.Tempaku, T.Mizuno, M.Hasegawa, A.Saito, N.Yamashita, H.Atsumi, T.Ito, K.Ishigami, M.Miura, Y.Izumi,
N.Kurose, H.Minato, T.Nojima, T.Kanda, N.Takekoshi: Interleukin-6 expressing colon cancer with multiple hepatic
metastases, J. Kanazawa. Med. Univ., 36:106-110, 2011.

9100D002

T.Mizuno, K.Ishigami, D. Sakamoto, R.Isahii, T.Kanda: Two types of Brugada-like ST-elevation in patients withfebrile infection, J. Kanazawa. Med. Univ., 36:124-126, 2011.

Presentations at Conference
International Conference (Presentations)
9100I001

Y.Izumi, N.Takekoshi, T.Kanda, T.Mizuno, Y.Ozawa, Y.Kasamaki, M.Ohta, T.Nakayama, H.Kawamura,
M.Mahemuti, D.Himit: Differences in organ damage for dipper and non-dipper patterns in 2 ethnic groups,
European Society of Hypertension (ESH) 2011: 21st European Meeting on Hypertension, (Milan, '11.06).

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Kanazawa Medical University
Research Activities and Publications 2011
Published December, 2012
Issuer: Shogo Katsuda
Editer: Hideaki Nakagawa
Publishing office: Kanazawa Medical University Publication office
1-1 Daigaku,Uchinada-machi,Kahoku-gun,Ishikawa-ken,Japan,920-0293
Tel +81 76 286 2211(Representative)

Printing office: TANAKA&SHOBUNDO GRAPHIC ART Co.LTD.

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