I

Liberal

N

Arts

D E

0260

X

Department of Medical Education ････････････400010

Department of Human Science (Humanities) ･･･1

0030

Department of Human Science (Mathematics) ･･20040

Department of Life Science

0300

Department of Cardiovascular Medicine ･･･････41(Natural Science:Physics) ････････････････････30310

Department of Respirolgy (Respiratory Medicine)･･43

Department of Life Science

0320

Department of Gastroenterology ･････････････46(Natural Science:Chemistry) ･･････････････････40330

Department of Nephrology ････････････････････48

Department of Life Science

0340

Department of Endocrinology and Metabolism･･･50(Natural Science:Biology) ･････････････････････50350

Department of Hematology and Immunology ･･･52

Department of Human Science

0360

Department of Neurology ･････････････････････54(Foreign Languages:English) ･･････････････････6

0370

Department of Geriatric Medicine･･････････････56

Department of Human Science

0380

Department of Pediatrics ･････････････････････58(Foreign Languages:German) ･･････････････････70390

Department of Neuropsychiatry ･･･････････････60

0090 Department of Life Science (Physical Education) ･･･80400

Department of Diagnostic and Therapeutic

0050

0060

0070

0080

ClinicalMedicine

Radiology ･･･････････････････････････････････62

Basic
0100

0110

0120

Medicine

0410

Department of Cardiovascular Surgery ･･････64

Department of Molecular and Cell Structural

0420

Department of Surgical Oncology ････････････66

Science (Anatomy Ⅰ) ････････････････････････90430

Department of Orthopedics Surgery ･･･････････68

Department of Molecular and Cell Structural

0440

Department of Neurosurgery ･････････････････71

Science (Anatomy Ⅱ) ････････････････････････110450

Department of Plastic and Reconstructive
Surgery ････････････････････････････････････73

Department of Physiology Ⅰ･･････････････････120130 Department of Physiology Ⅱ ･･････････････････13

0460

Department of Pediatric Surgery ･･････････････75

0140

Department of Biochemistry Ⅰ･･･････････････15

0470

Department of Ophthalmology ････････････････77

0150

Department of Biochemistry Ⅱ ･･････････････170480

Department of Otolaryngology ････････････････81

0160

Department of Pharmacology ････････････････18

0490

Department of Dermatology･･･････････････････84

0170

Department of Oncologic Pathology ･･････････190500

Department of Urogenital Surgery ････････････87

0180

Department of Pathophysiological and0510

Department of Obstetrics and Gynecology ･････89

Experimental Pathology ････････････････････220520

Department of Anesthesiology andPerioperative edicine ････････････････････････92

0190

Department of Microbiology ･････････････････25

0200

Department of Fundamental Research for CAM ･･27

0530

Department of Oral and Maxillofacial Surgery･･94

0210

Department of Medical Zoology･･･････････････29

0550

Department of Emergency Medicine････････････96

0220

Department of Pathology and Laboratory

0560

Department of Medical Oncology ･･････････････97

Medicine ･･･････････････････････････････････30

0610 Health Management Center･･････････････････99

Department of Social and Environmental

0620

Department of Pathology ････････････････････103

Medicine ･･･････････････････････････････････32

0630

Department of General Internal Medicine ･････104

0240 Department of Epidemiology and Public Health ･･･35

0640

Endoscopy Center ･･･････････････････････････106

0250

0650

Department of Rehabilitation Medicine ･･･････107

0230

Department of Legal Medicine ･･･････････････39

Code

0660

Department

Page

Department of Respirology (Thoracic Surgery) ･･･108

0670 Lifestyle-related Diseases Center ･････････････110
0680

Medical Genetic Center･･･････････････････････111

MedicalResearch

Institute

0740

Division of Human Genetics (Biochemistry) ･･･112

0750

Division of Human Genetics (Clinical Medicine) ･･114

0770

Division of Core Facility (Radioisotope Center) ･･･116

0780

Division of Core Facility(Experimental Animal Center) ･･･････････････117

0790

Division of Core Facility(Morphological Equipment Center) ･･･････････118

0800

Division of Core Facility(High-Tech Research Center) ････････････････119

0900

Division of Cell Medicine ････････････････････122

0910

Division of Advanced Medicine ･･･････････････124

0920

Division of Molecular Oncology and Virology ････126

0930

Division of Dermatomycology(Novartis Pharma) ･････････････････････････128

0940

Division of Taxus Research (Kotosugi) ････････130

0970

Division of Vision Research forEnvironmental Health ･･････････････････････131

Code

Department

Page

Liberal
0010

Arts

Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

Professor

HIRAGUCHI Tetsuo

environmental-ethnoarchaeology， peace studies．

Associate Professor

TAKEDA Koichi

Philosophy , History of logic

Keywords of Researchzoo-archaeology, cetacean, dolphin, whale, faunal remains, environmental archaeology, whaling, ancient diet, Palaeolithic
period, Jomon period, ethno-archaeology, anthropological education, logic, metaphysics, form, content, predicate, category,
deduction, induction, matter, being, substance, definion

Outline of Research
Hiraguchi:Environmental and ethnological archaeology, especially prehistoric whaling, and anthropological education for
medical students.
Takeda:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

Publications
Originals
0010B001

Koichi Takeda: Analogia in Aristotle, Mem. Lib. Kanazawa Med. Univ., 34:1-15, 2006 (in Japanese) .

Others0010F001

T.Hiraguchi: Pioneers of modern whaling and traditional whale hunts of Kaga and Noto, Reports and Proceedings:
the 4th summit of Japanese traditional whaling communities., 133-141, 2006.

－ 1 －

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

Associate Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

YOSHINO Kenichi

Algebra theory, number theory

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, isotropy group

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field

－ 2 －

0040

Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

Associate Professor

MATSUDA Kiyotsuna Study on Physics Education for Medical College

Senior Assistant Professor

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics

Keywords of Researchphysics education, computer simulation, physical experiment, demonstration, elementary particle physics, acoustic
environment

Outline of Research
Matsuda: I study physics education for a medical student. 1. A physics curriculum 2. The teaching materials 3. Developmentof An experimental device 4. A computer support physics learning system
Nakamura: In order that the student who majors in life science may deepen an understanding of a lecture, and in order toenable independent learning, we are developing the stude support which used a demonstration experiment and intranet.

Publications
Originals
0040B001

K.Nakamura: The Demonstration Apparatus for Acoustic Impedance Matching, Mem. Lib. Kanazawa Med. Univ.,
34:17-20, 2006 (in Japanese) .

－ 3 －

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

Associate Professor

MIYOSHI Fumihisa

organic synthetic chemistry, solid-state reaction, chemistryeducation

Research Associate

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

Publications
Originals
0050B001

T.Ota, M.Maeda, S.Suto, X.Zhou, M.Murakami, T.Takegami, M.Tatsuka: RhoGDIβ lacking the N-terminal
regulatory domain suppresses metastasis by promoting anoikis in v-src transformed cells., Clin. Exp. Metastasis.,23:323-334, 2006.

Presentations at Conference
International Conference (Presentations)
0050I001

T.Ota, M.Maeda, M.Murakami, T.Takegami, A.Kanda, M.Tatsuka: RhoGDIβ lacking the N-terminal regulatory
domain suppresses metastasis by promoting anoikis in v-src transformed cells., The 11th International Congress ofMetastasis Research Society Jointed with the 15th Annual Meeting of Japanese Association for Metastasis
Research, (Hiroshima, '06.09).

－ 4 －

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

Professor

HORI Isao

Development of ascidians

Associate Professor

ASAI Etsuo

Regeneration of planarians

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell

Outline of Research
It is well known that planarians have a strong power of regeneration. This power depends mainly on a large number ofundifferentiated stem cells or neoblasts which distribute through the parenchymal region of intact planarians. I have studied
differentiation,proliferation and morphogenesis of these neoblasts by using an electron microscope. Neoblasts are small insize and oval in shape. Their cytoplasm is occupied with free ribosomes and mitochondria. Synthetic organelles are notdeveloped. Most characteristic feature is several chromatoid bodies surrounding the nuclear envelope.
Their size and number reduce during cell differentiation. Formation of the chromatoid bodies is inhibited by actinomycin D.
These results suggest that chromatoid bodies relate to differentiation of neoblasts. I also studied the process ofmorphogenesis of muscle layers, gastrodermis and epidermis after decapitation. The data suggest that a kind of
neuropeptides and retinoic acid stimulate cell differentiation within the regeneration blastema.

Presentations at Conference
International Conference (Presentations)
0060I001

I.Hori: Effects of retinoic acid on regeneration of the planarian Dugesia, 10th International Symposium on Flatworm
Biology, (Innsbruck Austria, '06.07).

－ 5 －

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

Professor

OHTAKI Sachiko

Medical English, Intercultural Communication, Statement analysis

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works

Senior Assistant Professor

CURRY Carla

English education from a viewpoint of music

Keywords of Research
medical research article, schematic analysis, cultural variation, rhetorical variation, low-context communication, highcontext communication, contrastive analysis, comparative discourse analysis, cross-cultural differences, conclusion
sections, genre analysis, moves analysis, medical encounter, doctor-patient communication, novel, individualism, quest,
existentialism, Buildungsroman, humor, irony, narration, suffering, humanity

Outline of Research
Otaki: Achieve the best cross-cultural communication with the medical connection; think that is helped.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
C.Curry: My research has focused on using music in the classroom to teach English pronunciation, rhythm, and tone.
Students can quickly grasp the main elements of English sound structures when illustrated through chants and songs. I am
also interested in how to teach phonics to students who do not use a language represented by a phonetic alphabet.
Therefore, I have been studying the various techniques for teaching English phonics to young learners in Japan.

Publications
Originals
0070B001

K.Kakizaki: The control of distance in the narration in Seize the Day., Journal of English Language and Literature,
54:135-151, 2006.

－ 6 －

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

Associate Professor

HARA Akira

Austria literature led by Hofmannsthal

Senior Assistant Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

Publications
Originals
0080B001

公地宗弘: Dichtung als Veränderung der Wirklichkeit--Goethes "Torquato Tasso" und der Sturm und Drang--,
Goethe-Jahrbuch Japanische Ausgabe, 48:61-81, 2006 (in Japanese) .

Others0080F001

M.Kouchi: Roy Pascal : Die Sturm-und-Drang-Bewegung, Mem. Lib. Kanazawa Med. Univ., 34:43-75, 2006 (inJapanese) .

－ 7 －

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation

Associate Professor

YAMASHINA Tadahiko

Senior Assistant Professor

UEDA Fumio

Muscle Strength, Muscle Strength Training, Thickness of Muscles inthe Lower leg
Physical strength and a study about the athletic capability，Abasketball competition

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Yamashina : To find an effective way to prevent falling ,I have studied the ability to sustain a standing posture and fallingmechanism.
To clarify the association between antigravity muscles and the ability to sustain static and active standing posture.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.

Publications
Originals
0090B001

T.Yamashina: The Association between Antigravity muscles and Balancing Ability, Mem. Lib. Kanazawa Med.
Univ., 34:21-33, 2006 (in Japanese) .

0090B002

F.Ueda, N.Tamura, T.Yamashina: A Report on the Physical Fitness and Motor Ability of Kanazawa Medical
University Students(XXXII), Mem. Lib. Kanazawa Med. Univ., 34:35-42, 2006 (in Japanese) .

－ 8 －Basic0100

Medicine

Department of Molecular and Cell Structural Science (Anatomy Ⅰ)

Faculty
Title

Name

Field of Specialization

Professor

HIRAI Keiichi

Medical science of free radical

Senior Assistant Professor

HIGASHI Nobuaki

macroscopic anatomy

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical

Research Associate

UEDA Tadashi

The injury and regeneration of the cardiovascular and respiratory
systems by using cytochemical analysis

Keywords of Research
anticancer, antioxidant, apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical,
immunohistochemistry, human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive
oxygen species, superoxide, scavenger, anomaly of muscles and blood vessels, VDAC

Outline of Research
1. Cytochemical study of the cytotoxicity by reactive oxygen species.
2. Mechanism of mitochondrial damage induced by paraquat and quinones.

Publications
Originals
0100B001(J.Koyama), I.Morita, N.Kobayashi, K.-I.Hirai, E.Simamura, T.Nobukawa, S.Kadota: Antiallergic activity of
aqueous extracts and constituents of Taxus yunnanensis., Biol.Pharm.Bull., 29:2310-2312, 2006.

0100B002

E.Simamura, K.-I.Hirai, H.Shimada, J.Koyama, Y.Niwa, S.Shimizu: Furanonaphthoquinones cause apoptosis ofcancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion
channel, Cancer Biol. Ther., 5:1523-1529, 2006.

0100B003

K.Ikai, E.Simamura, K-I.Hirai: The mechanisms of anti-cancer activity by the natural constituents of Taxus
yunnanensis, J. Kanazawa. Med. Univ., 31:165-171, 2006 (in Japanese) .

0100B004

K.Furuta, H.Shimada, Y-B.Shui: Defense of UV-induced cell death by antioxidant nutrients, J. Kanazawa. Med.
Univ., 31:157-164, 2006 (in Japanese) .

Others
0100F001(JY.Ueda), S.Awale, Y.Tezuka, E.Simamura, K.-I.Hirai, T.Nobukawa, A.Sato, S.Kadota: Growth inhibitory activityof wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis, PlantaMed., 72:1241-1244, 2006.

－ 9 －Presentations at Conference
International Conference (Synposium)
0100H001

K-I.Hirai, H.Shimada, E.Simamura: Biomedical Mechanisms for Toxication and Detoxication of Paraquat, The 3rdInternational Forum on Oxidative Stress and Aging, (Nagoya, '06.09).

－ 10 －

0110

Department of Molecular and Cell Structural Science (Anatomy Ⅱ)

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy,embryology,lymphatic vessels,microscopy.

Associate Professor

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve.

Senior Assistant Professor

YASUTAKA Satoru

immunocytochemistry,pituitary,cell proliferation,gross anatomy.

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry,pituitary,cell proliferation,electron microscopy.

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

Publications
Originals
0110B001

K.Fukui, R.Kominami, H.Shinohara, T.Matsumoto: Glucocorticoid induces micro-fat embolism in the rabbit: A
scanning electron microscopic study, J. Orthop. Res., 24:675-683, 2006.

0110B002(K.M.Myint), Y.Yamamoto, T.Doi, I.Kato, A.Harashima, H.Yonekura, T. Watanabe, H.Shinohara, M.Takeuchi, K.
Tsuneyama, N.Hashimoto, M.Asano, S.Takasawa, H. Okamoto, H.Yamamoto: RAGE control of diabetic
nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight
heparin, Diabetes, 55:2510-2522, 2006.

－ 11 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Associate Professor

SUGAI Tokio

Neurophysiology

Senior Assistant Professor

SUGITANI Michio

Neurophysiology

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single
neuron integrates many inputs thereunto, so as to determine whether the
output signal is released or not. Neurons are connected to each other bysynapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one ormore neurons are able to regulate neuron excitability and synaptic
efficiency. In particular, we are interested in studying in vitro how theversatile intracellular messenger calcium ion mediates a number of signals
differentially, thereby achieving adequate regulation of synaptic efficiency and neuron excitability. As another research
topic, we are also studying feature detection mechanisms in pheromone-based olfactory sensation by using in vivo
preparation.

Publications
Originals
0120B001

H.Yoshimura, M.Honjo, N.Segami, K.Kaneyama, T.Sugai, Y.Mashiyama, N.Onoda: Cyclic AMP-dependent
attenuation of oscillatory-activity-induced intercortical strengthening of horizontal pathways between insular andparietal cortices, Brain Res., 1069:86-95, 2006.

0120B002(R.Udagawa), M.Nakano, N.Kato: Blocking L-type calcium channels enhances long-term depression induced by
low-frequency stimulation at hippocampal CA1 synapses, Brain Res., 1124:28-36, 2006.

0120B003

T.Sugai, H.Yoshimura, N.Kato, N.Onoda: Component-dependent urine responses in the rat accessory olfactorybulb, Neuroreport., 17:1663-1667, 2006.

－ 12 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

MIYAMAE Shunichi

Cardiac Electrophysiology

Research Associate

TAKANO Hiromichi

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001(K. Sonoyama), H. Ninomiya, O. Igawa, Y.Kaetsu, Y.Furuse, T.Hamada, J. Miake, P. Li, Y. Yamamoto, K. Ogino,
A. Yoshida, S. Taniguchi, Y. Kurata, S. Matsuoka, T. Narahashi, G. Shiota, Y. Nozawa, H. Matsubara, M.
Horiuchi, Y. Shirayoshi, I. Hisatome: Inhibition of inward rectifier K+ currents by angiotensin Ⅱ in rat atrial
myocytes: Lack of effects in cells from spontaneous hypertensive rats, Hypertens. Res., 29: 923-934, 2006.

0130B002(E. Mizuta), H. Furuichi, Y. Kazuki, J. Miake, S. Yano, U. Bahrudin, Y. Yamamoto, O. Igawa, C. Shigemasa, K.
Hidaka, T. Morisaki, Y. Kurata, H. Ninomiya, M. Kitakaze, Y. Shirayoshi, M. Oshimura, I. Hisatome: Delayed
onset of beating and decreased expression of T-type Ca2+channel in mouse ES cell-derived cardiocytes carrying
human chromosome 21, Biochem. Biophys. Res. Commun., 351:126-132, 2006.

0130B003

S.Cui., T.Shibamoto, W.Liu, H.Takano, Y.Kurata: Effects of platelet-activating factor, thromboxane A2 andleukotriene D4 on isolated perfused rat liver, Prostaglandins Other Lipid Mediat., 80:35-45, 2006.

0130B004

S.Cui., T.Shibamoto, W.Liu, H.Takano, Z.S.Zhao, Y.Kurata: Effects of Hct on L-NAME-induced potentiation ofanaphylactic presinusoidal constriction in perfused rat livers, J. Cardiovasc. Pharmacol., 48:827-833, 2006.

0130B005

S.Cui., T.Shibamoto, Z.Ruan, H.Takano, W.Liu, Y.Kurata: Oxygen consumption, assessed with the oxygen
absorption spectrophotometer, decreases independently of venoconstriction during hepatic anaphylaxis in perfused
rat liver, Shock, 26:62-68, 2006.
－ 13 －

0130B006

T.Shibamoto, T.Ishibashi, T.Shimo, S.Cui, H.Takano, H.Tsuchida, M.Nishio, Y.Kurata: NG-nitro-L-arginine
methyl ester potentiates anaphylactic venoconstriction in rat perfused livers, Clin. Exp. Pharmacol. Physiol.,
33:1073-1077, 2006.

Reviews
0130C001

H.Takano, Y.Kurata, T.Shibamoto: Spreading dilatation in small arteries, J. Kanazawa. Med. Univ., 31:127-131,
2006 (in Japanese) .

－ 14 －

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

DATE Takayasu

Mechanisms of chromosome segregation and DNA repair.

Associate Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Research Associate

MATSUI Tadashi

Functional analysis of protein kinases

Research Associate

HASHIMOTO
Mitsumasa

The function analysis of protein kinase PKU-beta

Faculty

Keywords of Research
gene analysis, double-stranded RNA-activated protein kinase (PKR), p53, 53BP1, 53BP2, RNA and DNA binding, PKUβ(TLK1), DNA repair, cell cycle, signal transduction

Outline of Research
PKU-beta/TLK-1 is a nuclear serine/threonine protein kinase, initially found in our laboratory. Recent study shows that it
controls multiple aspects of cell cycle, especially in progressions of S phase and mitosis. PKU-beta/TLK deficient cells or
it’s over-expressing cells contain aberrant chromosomes resulting in lethal. Main study in progress is to know how thekinase interacts with other cell cycle-dependent complex and regulates them.

Publications
Originals
0140B001

K.Iwabuchi, M.Hashimoto, T.Matsui, T.Kurihara, H.Shimizu, N.Adachi, M.Ishiai, K-I.Yamamoto, H.Tauchi,
M.Takata, H.Koyama, T.Date: 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70
or Artemis., Genes Cells, 11: 935-948, 2006.

0140B002

K.Kawamura, N.Morita, C.Domiki, K.Fujikawa-Yamamoto, M.Hashimoto, K.Iwabuchi, K.Suzuki: Induction ofcentrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure, Cancer Sci., 97:252258, 2006.

Presentations at Conference
International Conference (Presentations)
0140I001

T.Matsui, M.Hashimoto, K.Iwabuchi, T.Date: Short double-stranded RNAs inhibit activation of double-stranded
RNA-activated protein kinase (PKR), 20th IUBMB International Congress of Biochemistry and Molecular Biology,(Kyoto, '06.06).

0140I002

K.Iwabuchi, T.Matsui, M.Hashimoto, T.Date: A 53BP1-dependent repair pathway contributes to survival of cells
irradiated with ionizing radiation during G1, 20th IUBMB International Congress of Biochemistry and Molecular
Biolog, (Kyoto, '06.06).

0140I003(M.Matsumoto), K.Yaginuma, A.Igarashi, K.Iwabuchi, T.Date, T.Mori, K.Yamashita, M.Inobe, T.Matsunaga: UVinduced phosphorylation of histone H2AX dependent on nucleotide excision repair in quiescent cells., 20th IUBMBInternational Congress of Biochemistry and Molecular Biology, (Kyoto, '06.06).

－ 15 －

0140I004

M.Hashimoto, T.Matsui, T.Hamada, M.Ozaki, K.Iwabuchi, T.Date: Human PKU-β/TLK1 contributes to proper
chromosomal segregation and positioning of centrosomes during mitosis, 20th IUBMB International Congress ofBiochemistry and Molecular Biology, (Kyoto, '06.06).

－ 16 －

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Faculty

Associate Professor

Molecular mechanisms of angiogenesis, MicroRNA function,
Alternative RNA processing
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein

Associate
Professor(Additional Post)

NAGAO Yosinobu

Spermatogenesis, Effects of endocrine disruptors

Research Associate

TSURUOKA Naoki

Alternative processing of mRNA, Bioactivity of collagen tripeptide

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

K.Fujimura, N.Segami, Y.Yoshitake, N.Tsuruoka, K.Kaneyama, J.Sato, S.Kobayashi: Electrophoretic separation of
the synovial fluid proteins in patients with temporomandibular joint disorders, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 101:463-468, 2006.

0150B002(K.M.Myint), Y.Yamamoto, T.Doi, I.Kato, A.Harashima, H.Yonekura, T. Watanabe, H.Shinohara, M.Takeuchi, K.
Tsuneyama, N.Hashimoto, M.Asano, S.Takasawa, H. Okamoto, H.Yamamoto: RAGE control of diabetic
nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight
heparin, Diabetes, 55:2510-2522, 2006.

Presentations at Conference
International Conference (Presentations)
0150I001

H.Yonekura, H.Li, Y.Yamamoto, K.Ohe, S.Hossain, I.Nozaki, T.Takiya, S.Futo, T.Watanabe, H.Yamamoto:
Identification of a new human angiostatic gene by the Antisense Display method - pICln, a regulator of alternative
3'-end processing of VEGF receptor pre-mRNAs., The 20th IUBMB International Congress of Biochemistry andMolecular Biology and 11th FAOBMB Congress, (Kyoto, '06.06)，Abstructs, 130, 2006.

－ 17 －

0160

Department of Pharmacology

Faculty
Title

Name

Field of Specialization

Professor

NISHIO Matomo

Associate Professor

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Pharmacology in cardiovascular system, Cancer chemotherapy

Researcher

NISHIZAWA Naoki

Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular system, Cancer chemotherapy

Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystem

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, photolysis, excitable membrane, cardiovascular system,
ischemic disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary
circulation, nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor
drug, proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

T.Shibamoto, T.Ishibashi, T.Shimo, S.Cui, H.Takano, H.Tsuchida, M.Nishio, Y.Kurata: NG-nitro-L-arginine
methyl ester potentiates anaphylactic venoconstriction in rat perfused livers, Clin. Exp. Pharmacol. Physiol.,
33:1073-1077, 2006.

Presentations at Conference
International Conference (Presentations)
0160I001

J.Yoshida, T.Ishibashi, M.Nishio: Antiproliferative effect of amlodipine, a dihydropyridine Ca2+ channel blocker, on
human epidermoid carcinoma A431 cells, 15th World Congress of Pharmacology, (Beijing, China, '06.07)，Acta
Pharmacologica Sinica, (Suppl. 1):65, 2006.

0160I002

J.Yoshida, T.Ishibashi, M.Nishio: G1 cell cycle arrest induced by amlodipine, a dihydropyridine Ca2+ channel
blocker, in human epidermoid carcinoma A431 cells, The 18th Japan-Korea Joint Seminar on Pharmacology,(Fukui, '06.09).

－ 18 －

0170

Department of Oncologic Pathology

Faculty
Title

Name

Field of Specialization

Professor

TANAKA Takuji

Inhibition of carcinogenesis, Oncologic pathology of digestive organ,
Experimental pathology

Professor

SUGIE Shigeyuki

Experimental pathology, Oncologic pathology of digestive organ

Associate Professor

KOHNO Hiroyuki

Experimental pathology,Tumor immunologg

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Publications
Originals
0170B001(Y.Mori), K.Tatematsu, A.Koide, S.Sugie, T.Tanaka, H.Mori: Modification by curcumin of mutagenic activation ofcarcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats, Cancer Sci., 97:896-904,
2006.

0170B002

T.Tanaka, H.Kohno, R.Suzuki, K.Hata, S.Sugie, N.Niho, K.Sakano, M.Takahashi, K.Wakabayashi: Dextran sodium
sulfate strongly promotes colorectal carcinogenesis in ApcMin/+ mice: Inflammatory stimuli by dextran sodium sulfate
results in development of multiple colonic neoplasms, Int. J. Cancer., 118:25-34, 2006.

0170B003(K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, T.Kuno, Y.Hirose, A.Hara, H.Mori: Lack of enhancing effects
of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiatedwith azoxymethane, Cancer Lett., 238:69-75, 2006.

0170B004(K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, Y.Yamada, T.Oyama, T.Kuno, Y.Hirose, A.Hara, H.Mori:β-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice, Cancer Lett., 239:123-128, 2006.

0170B005

R.Suzuki, H.Kohno, S.Sugie, H.Nakagama, T.Tanaka: Strain differences in susceptibility to azoxymethane anddextran sodium sulfate-induced colon carcinogenesis in mice, Carcinogenesis, 27:162-169, 2006.

0170B006

R.Suzuki, H.Kohno, M.Suzui, N.Yoshimi, H.Tsuda, K.Wakabayashi, T.Tanaka: An animal model for the rapid
induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its
potential use for preclinical chemoprevention studies, Carcinogenesis, 27:619-630, 2006.
－ 19 －

0170B007

H.Kohno, R.Suzuki, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka: Dietary administration withprenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice, Int. J. Cancer.,
118:2936-2942, 2006.

0170B008(S.Miyamoto), H.Kohno, R.Suzuki, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka: Preventive effects of chrysin on
the development of azoxymethane-induced colonic aberrant crypt foci in rats, Oncol. Rep., 15:1169-1173, 2006.

0170B009

Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita: Growth inhibition and apoptosis induction by all-transconjugated linolenic acids on human colon cancer cells, Anticancer Res., 26:1855-1860, 2006.

0170B010

R.Suzuki, Y.Yasui, H.Kohno, S.Miyamoto, M.Hosokawa, K.Miyashita, T.Tanaka: Catalpa seed oil rich in
9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced byazoxymethane in rats, Oncol. Rep., 16:989-996, 2006.

0170B011

R.Suzuki, H.Kohno, Y.Yasui, K.Hata, S.Sugie, S.Miyamoto, K.Sugawara, T.Sumida, Y.Hirose, T.Tanaka: Diet
supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions
and fatty liver in male db/db mice, Int. J. Cancer., 120:252-258, 2006.

0170B012(T.Kawamori), W.Osta, KR.Johnson, BJ.Pettus, J.Bielawski, T.Tanaka, MJ.Wargovich, BS.Reddy, YA.Hannun,
LM.Obeid, D.Zhou: Sphingosine kinase 1 is up-regulated in colon carcinogenesis, FASEB J., 386-388, 2006.

0170B013

Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita: Troglitazone and 9cis,11trans,13trans-conjugatedlinolenic acid: Comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer celllines, Chemotherapy, 52:220-225, 2006.

0170B014(M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Nohmi: Chemopreventive Effects of Nobiletin
against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta
Transgenic Mice, Genes and Environment, 28:84-91, 2006.

0170B015(M.Suzui), T.Tanaka, H.Mori, T.Nakayama, M.Aonahata, N.Yoshimi: Pulmonary hypoplasia and chondrocyte
p21CIP1 expression in patients with lethal short-limbed dwarfism, Ryuku Med.J., 25:41-46, 2006.

0170B016(F.Beppu), M.Hosokawa, L.Tanaka, H.Kohno, T.Tanaka, K.Miyashita: Potent inhibitory effect of trans9, trans11
isomer of conjugated linoleic acid on the growth of human colon cancer cells, J. Nutr. Biochem., 17:830-836, 2006.

Reviews
0170C001

T.Tanaka, S.Miyamoto, R.Suzuki, Y.Yasui: Chemoprevention of colon carcinogenesis by dietary non-nutritive
compounds, Curr. Topics Nutraceut. Res., 4:127-152, 2006.

0170C002

S.Sugie, T.Tanaka: Significance of hyperplastic lesions in chronic toxicity studies in rodents, J. Kanazawa. Med.
Univ., 31:124-126, 2006 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0170H001

H.Kohno, R.Suzuki, S.Miyamoto, T.Sumida, K.Sugawara, S.Sugie, T.Tanaka: Citrus unshiu segment membrane
suppresses azoxymethane-induced colonic aberrant crypt foci and β-catenin accumulated crypts in male db/db
mice, 4th Regional APOCP Conference, Synposium IV-Pathlogy and Chemoprevention, (Nagoya, '06.01).

International Conference (Presentations)
0170I001(S.Miyamoto), R.Suzuki, H.Kohno, S.Sugie, T.Tanaka: Dietary auraptene inhibits azoxymethane-induced colonic
aberrant crypt foci in female db/db mice, 4th Regional APOCP Conference, (Nagoya, '06.01).

0170I002

T.Tanaka: Cancer chemeoprevention by laactoferrin and its possible mechanisms, 4th Regional APOCP
Conference, Lunchtime Seminar, (Nagoya, '06.01).

－ 20 －

0170I003(M.Kim), A.Murakami, T.Tanaka, H.Ohigashi: Effects of green tea polyphenols on dextran sulfate sodium-induced
colitis in male ICR mice, 97th Annual Meeting of American Association for Cancer Research, (Washington, DC,'06.04).

0170I004(A.Murakami), T.Nishizawa, M.Yasuda, T.Tanaka, N.H.Colburn, H.Ohigashi: Linoleic acid metabolite suppresses
skin tumor promotion in mice and induces programmed cell death protein 4 in mouse epidermal JB6 cells, 97th
Annual Meeting of American Association for Cancer Research, (Washington, DC, '06.04).

0170I005

H.Kohno, R.Suzuki, S.Miyamoto, S.Sugie, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka: Suppression ofcolitis-related mouse colon carcinogenesis by dietary administration with prenyloxycoumarins, auraptene andcollinin, 97th Annual Meeting of American Association for Cancer Research, (Washington, DC, '06.04).

0170I006

S.Sugie, R.Suzuki, H.Kohono, T.Tanaka, H.Mori: Modifying effect of thiol compounds on diethylnitrosamine(DEN)-phenobarbital (PB) induced rat hepatocarcinogenesis, 97th Annual Meeting of American Association forCancer Research, (Washington, DC, '06.04).

0170I007

T.Tanaka, R.Suzuki, H.Kohno, K.Hata, S.Sugie, S.Miyamoto, K.Sugawara, T.Sumida, Y.Hirose: Diet supplemented
with citrus unshiu segment membrane suppresses azoxymethane-induced colonic aberrant crypt foci and betacatenin accumulated crypts in male db/db mice, 97th Annual Meeting of American Association for Cancer
Research, (Washington, DC, '06.04).

0170I008(F.Epifano), M.Curini, S.Genovese, L.Menghini, T.Tanaka: Synthesis and preliminary colon cancer
chemoprevention evaluation of a novel prodrug of 4’-geranyloxy-ferulic acid, active principle of Acronychia baueri
Schott, GA 2006 - International Congress and 54th Annual Meeting of the Society for Medicinal Plant Research,(Helsinki, Finland, '06.08).

0170I009

Y.Yasui, H.Kohno, R.Suzuki, S.Miyamoto, S.Sugie, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka:
Inhibition of colitis-related mouse colon carcinogenesis by dietary administration with prenyloxycoumarins,
auraptene and collinin, The Kadota Fund International Forum 2006, (Inuyama, '06.11).

0170I010(M.Yamamoto), N.Ishibashi, T.Tanaka: Prevention of Rat Hepatocarcinogenesis by NIK-333 and Effect of Connexin
Expression in liver, International Conference of Physiological and Pathological Importance of Gap Junctions,(Tokyo, '06.11).

－ 21 －

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

Professor

KATSUDA Shogo

Vascular pathology, Pathophysiology of ECM

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Professor(Additional Post)

ISHIKAWA Yoshimaro Histochemistry

Senior Assistant Professor

SATO Katsuaki

Neuropathology

Researcher

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami,
I.Yamamoto: Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lungadenocarcinomas, J. Nucl. Med., 47:419-425, 2006.

0180B002

T.Ichiseki, Y.Ueda, S.Katsuda, K.Kitamura, A.Kaneuji, T.Matsumoto: Oxidative stress by glutathione depletioninduces osteonecrosis in rats, Rheumatology (Oxford), 45:287-290, 2006.

0180B003

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0180B004

E.Hatano, T.Fujita, Y.Ueda, T.Okuda, S.Katsuda, Y.Okada, T.Matsumoto: Expression of ADAMTS-4(aggrecanase-1) and possible involvement in regression of lumbar disc herniation, Spine, 31:1426-1432, 2006.

0180B005(H.Yoshikawa), K.Sato, S.Edahiro, Y.Furukawa, T.Maruta, K.Iwasa, H.Watanabe, S.Takaoka, Y.Suzuki,
M.Takamori, M.Yamada: Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma, J.
Neuroimmunol., 175:169-175, 2006.

－ 22 －

0180B006

S.Matsui, L.Larsson, M.Hayase, S.Katsuda, K.Teraoka, T.Kurihara, H.Murano, K.Nisikawa, M.Fu: Specificremoval of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy
improved cardiac structure and function, J. Mol. Cell. Cardiol., 41:78-85, 2006.

0180B007

M.Sagawa, K.Higashi, M.Sugita, Y.Ueda, S.Maeda, H.Toga, T.Sakuma: Fluorodeoxyglucose uptake correlates withthe growth pattern of small peripheral pulmonary adenocarcinoma, Surg Today, 36:230-234, 2006.

Case Reports
0180D001

K.Sato, R.Waseda, Y.Tatsuzawa, H.Fujinaga, T.Wakabayashi, Y.Ueda, S.Katsuda: Composite large cell
neuroendocrine carcinoma and adenocarcinoma of the common bile duct, J. Clin. Pathol., 59:105-107, 2006.

0180D002

K.Sato, R.Waseda, Y.Tatsuzawa, R.Soma, Y.Ueda, S.Katsuda: Papillary thyroid carcinoma with anaplastictransformation showing a rhabdoid phenotype solely in the cervical lymph node metastasis, Pathol. Res. Pract.,
202:55-59, 2006.

0180D003

K.Sato, Y.Ueda, A.Sakurai, Y.Ishikawa, S.Kaji, T.Nojima, S.Katsuda: Adenoid cystic carcinoma of the maxillarysinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report withdedifferentiated carcinoma, Virchows Arch., 448:204-208, 2006.

0180D004

H.Shikata, K.Miyazawa, Y.Ueda, T.Kobata, K.Hida, J.Matsubara: A case of synchronous renal cell carcinoma
producing granulocyte colony stimulating factor(G-CSF) and abdominal aortic aneurysm, Jpn. J. Cardiovasc.Surg.,
15:521-524, 2006.

0180D005

K.Sato, Y.Ueda, M.Yokoi, K.Hayashi, T.Kosaka, S.Katsuda: Reactive lymphoid hyperplasia of the liver in a patientwith multiple carcinomas: a case report and brief review, J. Clin. Pathol., 59:990-992, 2006.

0180D006

M.Sugita, M.Sagawa, Y.Ueda, K.Higashi, T.Sakuma: Localized bronchioloalveolar carcinoma with small foci ofactive fibroblastic proliferation, Respiration, 73:694-697, 2006.

0180D007

K.Sato, Y.Ueda, H.Shikata, S.Katsuda: Bronchioloalveolar carcinoma of mixed mucinous and nonmucinous type:
Immunohistochemical studies and mutation analysis of the p53 gene, Pathol. Res. Pract., 202:751-756, 2006.

0180D008

K.Sato, H.Murai, Y.Ueda, S.Katsuda: Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a casereport and immunohistochemical studies, Virchows Arch., 449:585-590, 2006.

0180D009(R.Komoro), K.Kobayashi, M.Shimazaki, K.Sugimori, Y.Koshino, K.Sato, Y.Oda: Right parietal lobe syndrome as aclinical variant of Creutzfeldt-Jakob disease, Psychogeriatrics, 6:74-78, 2006.

0180D010

K.Sato, M.Takenaka, M.Nakano, T.Terauchi, Y.Ueda, S.Katsuda: A case of mixed mucinous and nonmucinous typebronchioloalveolar carcinoma, J. Jpn. Soc. Clin. Cytol., 45:103-105, 2006 (in Japanese) .

0180D011

K.Sato, Y.Uwami, Y.Nishida, K.Tanimoto, Y.Ueda, S.Katsuda: A case of renal collecting duct (Bellini duct)
carcinoma appeared in voided urine, J. Jpn. Soc. Clin. Cytol., 45:194-198, 2006 (in Japanese) .

0180D012(H.Tajima), J.Kinoshita, Y.Hayashida, K.Yoshimoto, H.Itoh, U.Fuchizaki, T.Kamata, H.Miyamori, M.Kannno,
K.Takeda, Y.Ueda: A case of erythroderma associated with gastric cancer and cecal carcinoma, The Hokuriku
journal of surgery., 25:17-19, 2006 (in Japanese) .

Others0180F001

K.Sato, H.Tachibana, T.Tsuzuki, Y.Ueda, S.Katsuda: Prostatic ductal adenocarcinoma mimicking villous adenomaof the urethra, Virchows Arch., 449:597-599, 2006.

－ 23 －

Presentations at Conference
International Conference (Presentations)
0180I001

T.Sakuma, J.Xu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, M.Shimazaki, Y.Ueda: Mechanisms responsible for acutepancreatitis-stimulated alveolar fluid clearance capacity in rat lungs, Experimental Biology, (San Francisco,'06.04).

0180I002

M.Iguchi, H.Kida, M.Saito, Y.Machida, K.Kojima, Y.Tachi, R.Hatta, K.Nakagawa, K.Tsuchihara, T.Tobe, T.Seki,
M.Takahashi, J.Huang, K.Osanai, H.Toga, M.Sagawa, T.Sakuma, Y.Ueda: Clinical evaluation of micropapillaryadenocarcinoma of the lung, 11th Congress of the Asian Pacific Society of Respirology, (kyoto, '06.11)，
Respirology, 11:A251, 2006.

－ 24 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology，Neuroimmunology

Associate Professor

SAITO Mineki

Neurology，Neurovirology

Research Associate

TANIURA Naoko

Neurovirology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa: Theiler's murine encephalomyelitis virus leader proteinamino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells, J. Virol., 80: 12025-12031,
2006.

Reviews
0190C001

M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa: Leader (L) and L* proteins of Theiler's murine
encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities, J. Neuroinflammation., 3:1926, 2006.

Presentations at Conference
International Conference (Key Note Lecture)
0190G001

M. Saito: VIrus-host interactions and its implication in the development of HAM/TSP, 7th International
Symposium on NeuroVirology, (Philadelphia, '06.06).

International Conference (Presentations)
0190I001

M. Takano-Maruyama, T. Okuwa, K. Asakura, Y. Ohara: Theiler's murine encephalomyelitis virus subgroupspecific growth on BHK-21 cells is rehulated by amino acid 57 within the leader protein, 7th International
Symposium on NeuroVirology, (Philadelphia, '06.06)，J. NeuroVirol, 12:80, 2006.

0190I002

K. Asakura, Y. Kontani, Y. Ohara: The association of leader protein of Theiler's murine encephalomyelitis virus
with clathrin-assobiated protein AP50, The 8th International Congress of Neuroimmunology, (Nagoya, '06.10).

0190I003

T. Okuwa, M. Takano-Maruyama, K. Asakura, H. Murayama, Y. Ohara: Generation of a mutant of Theiler's
murine encephalomyelitis virus (TMEV) causing demyelination in the brain of susceptible mice, The 8thInternational Congress of Neuroimmunology, (Nagoya, '06.10).

－ 25 －

0190I004

M.Saito, K.Usuku, H.Nose, A.H.Sabouri, K.Arimura, S.Izumo, M.Osame, Y.Ohara: Virus-host interactions and its
implication in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis(HAM/TSP), The
8th International Congress of Neuroimmunology, (Nagoya, '06.10).

－ 26 －

0200

Department of Fundamental Research for CAM

Faculty
Title

Name

Field of Specialization

Professor

YAMAGUCHI Nobuo

Developmental immunology, Defense immunity, Tumor immunity,
Complemental medicine

Associate Professor

SHIMIZU Shoji

Immunology, Protective immunology, Tumor immunology

Senior Assistant Professor

MATSUNO Hideo

Allergy, Otolaryngology

Research Associate

MATSUBA Shintaro

Complemental medicine, Immunological pharmacology

Keywords of Researchpregnancy, maternal immunization, offspring, immune suppression, acquired immunodeficiency, immunomodulator, oral
immunity, herbal medicine, cytokine

Outline of Research
Our research is founded on immunology. To date, we have studied fields such as fetomaternal immunity, tumor immunity
and infectious immunity. With the graduate school reorganization in 2003, the name of the chair was changed with"Complementary and alternative medicine". Since then, we started the trial which verified alternative medicine of all thecountries of world by the immunological parameters. In order to achive these ends as effectively as possible, we planned the
publication of new international journal, Evidence-based Complementary and Alternative Medicine (eCAM). The journal
eCAM was published in 2004 and reached vol. 4th at present. In recent years, it has been proven that the neuroendocrinosystem adjusts the function of immune system and that there is a bidirectional regulation mechanism in these systems. We
examine the effect of hot spring hydrotherapy and walking exercise on number and function of the immunocompetent cells.
Hereafter, we aim at the establishment of an assessment of the alternative medicine throughout immunological parameters.

Publications
Originals
0200B001

T.Takahashi, Y.Fei, Z.Shi-jie, J.Moriya, H.Sumino, S.Morimoto, N.Yamaguchi, T.Kanda: Beneficial effect ofbrewers' yeast extract on daily activity in a murine model o f chronic fatigue syndrome, eCAM, 3:109-115, 2006.

0200B002

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0200B003(T.Murayama), N.Yamaguchi, K.Iwamoto, Y.Eizuru: Inhibition of ganciclovir-resistant human cytomegalovirus
replication by Kampo (Japanese herbal medicine), Antivir. Chem. Chemother., 17:11-16, 2006.

Reviews
0200C001

F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda:
Traditional chinese medicine and kampo: a review from the distant past for the future, J. Int. Med. Res., 34:231239, 2006.

－ 27 －

Presentations at Conference
International Conference (Synposium)
0200H001

Nobuo Yamaguchi: Aspect of immunological factors for estimating the efficacy of acupuncture and moxibustion,
International Symposium on Evidence Based Acupuncture, (Kyoto, '06.11).

－ 28 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Associate Professor

IKEDA Teruaki

Immunological and biochemical studies of parasitic diseases

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease，tick-borne disease

Senior Assistant Professor

ICHIKAWA Hidetaka Immunological study for parasitic diseases

Faculty

Keywords of Researchparasite, paragonimiasis, fascioliasis, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating
antigen, excretory/secretory products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba,
metacercaria, excystment, atopic dermatitis, mite, Myobia musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Study on the invading mechanism of lung flukes into their final hosts.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Development of immunological and molecular biological diagnosis of parasitic diseases.

Publications
Originals
0210B001

T.Ikeda: Effects of L-type Ca2+channel antagonists on in vitro excystment of Paragonimus ohirai metacercariae
induced by sodium cholate, Parasitol. Res., 99:336-340, 2006.

－ 29 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Senior Assistant Professor

FUKUNAGA
Toshiharu

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
laboratory medicine, standardization of blood gas analysis, pulmonary
function test

Research Associate

KUROSE Nozomu

surgical pathology, molecular pathology

Research Associate

KINOSHITA Erikosurgical pathology, molecular pathology

Research Associate

KAJI Sachikosurgical pathology,molecular pathology

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001(U.Tateishi), T.Hasegawa, T.Nojima, T.Takegami, Y.Arai: MRI features of extraskelal myxoid chondrosarcoma,
Skeletal Radiol., 35:27-33, 2006.

Case Reports
0220D001

K.Sato, Y.Ueda, A.Sakurai, Y.Ishikawa, S.Kaji, T.Nojima, S.Katsuda: Adenoid cystic carcinoma of the maxillarysinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report withdedifferentiated carcinoma, Virchows Arch., 448:204-208, 2006.

0220D002

T.Akai, K.Yamamoto, T.Iida, H. Iizuka, T.Nojima: Malignant fibrous histiocytoma in the craniocervical junction
presenting with severe occipitalgia, Brain Tumor Pathol., 23:101-105, 2006.

0220D003

H.Murai, S.Morimoto, I.Ohashi, K.Okaishi, H.Tsuchiya, K.Iwai, T.Nakahashi, Y.Nishimura, M.Okuro, E.Miyauchi,
T.Nojima, M.Matsumoto: A ninety-eight-year-old woman with ruptured pancreatic anaplastic mucinous
cystadenocarcinoma, Jpn. j. geriat., 43：246-251, 2006 (in Japanese) .

－ 30 －

Presentations at Conference
International Conference (Presentations)
0220I001

J.Huang, K.Kojima, Y.Tachi, T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai,
H.Toga: Expiratory flow limitation in the nasopharynx during wakefulness in patients with obstructive sleep apnea,
ATS 2006 International Conference, (San Diego, '06.05)，Proceeding of the Am.Thoracic Society, 3:A315, 2006.

0220I002

T.Nojima: Chondroblastoma -like osteosarcoma, 33rd Annual Meeting of Internattional Skeletal Society,(Vancouver, '06.09).

0220I003

T.Fukunaga: Quality assurace for the POCT (Point of Care Testing) in the blood gas analysis using the certified
reference materials, The American association for clinical chemistry critical and point-of-care testing division,(Canada, '06.09).

0220I004

M.Iguchi, H.Kida, M.Saito, Y.Machida, K.Kojima, Y.Tachi, R.Hatta, K.Nakagawa, K.Tsuchihara, T.Tobe, T.Seki,
M.Takahashi, J.Huang, K.Osanai, H.Toga, M.Sagawa, T.Sakuma, Y.Ueda: Clinical evaluation of micropapillaryadenocarcinoma of the lung, 11th Congress of the Asian Pacific Society of Respirology, (kyoto, '06.11)，
Respirology, 11:A251, 2006.

0220I005

K.Kojima, J.Huang, H.Yamamura, T.Fukunaga, H.Kida, M.Saito, Y.Machida, Y.Tachi, R.Hatta, K.Nakagawa,
T.Oikawa, K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai, H.Toga: Compliance ofnasopharyngeal wall estimated by posterior rhinomanometry in patients with obstructive sleep apnea : comparison
with dynamic CT imaging, 11th Congress of the Asian Pacific Society of Respirology, (Kyoto, '06.11)，Respirology,
11:A203, 2006.

0220I006

J.Huang, K.Kojima, T.Fukunaga, H.Kida, M.Saito, Y.Machida, Y.Tachi, R.Hatta, K.Nakagawa, T.Oikawa,
K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai, H.Toga: Influence of upper airway configuration
on lmpulse oscillometry measurement, 11th Congress of the Asian Pacific Society of Respirology, (Kyoto, '06.11)，
Respirology, 11:A224, 2006.

－ 31 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stressSenior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders

Senior Assistant Professor

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Senior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level
in Japanese workers, Clin. Exp. Hypertens., 28:47-56, 2006.

0230B002(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism
A1330V are risk factors for hypercholesterolemia in Japanese males –a prospective study over 5 years, Metab.
Clin. Exp., 55:751-757, 2006.

0230B003(M.Sakurai), K.Miura, T.Takamura, T.Ota, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Genderdifferences in the association between anthropometric indices of obesity and blood pressure in Japanese,
Hypertens. Res., 29:75-80, 2006.

0230B004(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanesemales, Life Sci., 78:2475-2479, 2006.

0230B005(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese
workers, Tohoku J. Exp. Med., 209:149-157, 2006.

0230B006(K.Wada), T.Satoh, M.Tsunoda, Y.Aizawa, and the Japan Work Stress and Health Cohort Study Group, M.Ishizaki:
Associations of health behaviors on depressive symptoms among employed men in Japan, Ind Health, 44:486-492,
2006.

－ 32 －

0230B007(M.Uetani), E.Kobayashi, Y.Suwazaono, R.Honda, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Tissue cadmium(Cd) concentrations of people living in a Cd polluted area, Japan, Biometals, 19:521-525, 2006.

0230B008(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit variant C825T is a risk factor for hypertension in Japanese females -a prospective cohort
study over 5 years, Ann. Hum. Genet., 70:767-777, 2006.

0230B009

M.Ishizaki, N.Kawakami, R.Honda, H.Nakagawa, Y.Morikawa, Y.Yamada, The Japan Work Stress and HealthCohort Study Group: Psychosocial work characteristics and sickness absence in Japanese employees, Int. Arch.
Occup. Environ. Health., 79:640-646, 2006.

0230B010(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females,
Blood Press., 15:80-87, 2006.

0230B011(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: The 1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γglutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: aprospective cohort study over 5 years, Int. J. Mol. Med., 17:77-82, 2006.

0230B012

Y.Yamada, T.Imai, M.Ishizaki, R.Honda: ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and thehealth consequences in moderate alcohol consumers, J. Hum. Genet., 51:104-111, 2006.

Presentations at Conference
International Conference (Presentations)
0230I001

H.Sasaki, K.Nagai, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson, K.Sasaki: Cataract in diabetes ; The Reykjavik
Eye Study, The Association for Research in Vision and Ophthalmolpgy, (Florida, '06.05).

0230I002

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The Association
for Research in Vision and Ophthalmology, (Florida, '06.05).

0230I003

K.Sasaki, H.Sasaki, K.Nagai, H.Yaguchi, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson: Five-Year's lightscattering changes inlens layers in diabetics - The Reykjavik Eye Study -, The Association for Research in Vision
and Ophthalmology, (Florida, '06.05).

0230I004

Y.Yamashiro, J.Qu, J.Tao, Y.Kawakami, M.Kojima, R.Honda, H.Sasaki, K.Sasaki: Characteristics of cataract ineyes with long axial length in a Chinese population, The Association for Research in Vision and Ophthalmology,(Florida, '06.05).

0230I005

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The 6th Asian
Cataract Research Conference, (Beijing, '06.06).

0230I006(J.Tao), J.Qu, R.Honda, M.Kojima, Q.Yan, J.Zhang, H.Sasaki, K.Sasaki: Prevalence of three main and six subtype
lens opacities in a rural Chinese population, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0230I007

K.Nagai, H.Sasaki, Y.Sakamoto, M.Kojima, K.Sasaki, F.Jonasson, R.Honda: Characteristics of lens opacity indiabetic patients - Reykjavik Eye Study -, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0230I008

S.Yoneyama, K.Miura, S.Sasaki, S.Yoshita, M.Morikawa, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Relationship of dietary intake of fatty acids to serum C-reactive protein in Japanese, 14th International Symposium
on Atherosclerosis, (Rome, '06.06)，Atherosclerosis, 7:290, 2006.

0230I009

M.Nishijo, H.Nakagawa, R.Honda: A trial for a global standard health management for Cd pollution, Health risk
management for environment and labour, (Tokyo, '06.06)，URMPM special conference, 52, 2006.

－ 33 －

0230I010

M.Ishizaki, Y.Morikawa, H.Nakagawa, R.Honda, N.Kawakami, T.Haratani, F.Kobayashi, S.Arai: Relationshipbetween change of job demand/control and absence from work, 28th International Congress on Occupational
Health, (Milan, '06.06)，Book of Abstracts, 292, 2006.

0230I011

Y.Noborisaka, M.Nakata, N.Kalezic, A.Crenshew, E.Lyskov, S.Karlsson, P-O.Eriksson: Physiological reactivity
and pain during chewing in Whiplash-Associated Disorder (WAD) patients and healthy controls, 84th General
Session and Exhibition of the International Association for Dental Research and American Association for Dental
Research, (Brisbane, '06.06)，2006 IADR Program Book, 89, 2006.

0230I012(N.Kawakami), T.Haratani, F.Kobayashi, M.Ishizaki, T.Hayashi, O.Fujita, Y.Aizawa, S.Miyazaki, H.Hiro,
T.Masumoto, S.Hashimoto, S.Araki: Job Insecurity and increased risk of stroke in Japanese men: a prospective
finding from the jstress study, 28th International Congress on Occupational Health, (Milan, '06.06)，Book of
Abstracts, 41, 2006.

0230I013

M.Nakata, Y.Noborisaka, Y.Nishijima, T.Kato, M.Boocock, N.Ishii, K.A.Ängquist: Evaluation of muscular workload
when handling ambulance stretchers, Healthcare Ergonomics and Patient Safety symposium International
Ergonomics Association Congress, (Maastricht, '06.07)，Program Book, 57, 2006.

0230I014

H.Sasaki, R.Honda, M.Kojima, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: High prevalence of pterygium in the
population of tropical area in China, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves,(Uchinada, '06.11).

－ 34 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Associate Professor

MIURA Katsuyuki

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

Associate Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Senior AssistantProfessor(Additional Post)

NAKANISHI Yumiko

Preventive medicine

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine
Cardiovascular epidemiology, preventive cardiology, clinicalepidemiology

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevention of Lifestyle-related Diseases (mainly of
Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Intractable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level
in Japanese workers, Clin. Exp. Hypertens., 28:47-56, 2006.

0240B002(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism
A1330V are risk factors for hypercholesterolemia in Japanese males –a prospective study over 5 years, Metab.
Clin. Exp., 55:751-757, 2006.

0240B003(Elliott.P), Stamler.J, Dyer.AR, Appel.L, Dennis.B, Kesteloot.H, H.Ueshima, A.Okayama, Chan.Q, Garside.DB,
Zhou.B, for the INTERMAP Cooperative Reserch Group, H.Nakagawa, K.Miura: Association between protein
intake and blood pressure: the INTERMAP study, Arch. Intern. Med., 166:79-87, 2006.

0240B004(M.Sakurai), K.Miura, T.Takamura, T.Ota, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Genderdifferences in the association between anthropometric indices of obesity and blood pressure in Japanese,
Hypertens. Res., 29:75-80, 2006.

－ 35 －

0240B005(S.Omote), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono, E.Kobayashi, N.Nogawa: Urinary type I collagen crosslinked N-telopeptides in inhabitants 18Years after cessation of exposure to cadmium in Japan, Bull. Environ.
Contam. Toxicol., 76:187-94, 2006.

0240B006

H.Nakagawa, M.Nishijo, Y.Morikawa, K.Miura, K.Tawara, J.Kuriwaki, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa:
Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan, Environ Res, 100:323-329,
2006.

0240B007(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanesemales, Life Sci., 78:2475-2479, 2006.

0240B008(M.Uetani), E.Kobayashi, Y.Suwazono, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Smoking does not influencecadmium concentrations in blood and urine in relatively high levels of environmental cadmiun areas in Japan, Biol
Trace Elem Res, 110:107-118, 2006.

0240B009(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese
workers, Tohoku J. Exp. Med., 209:149-157, 2006.

0240B010

K.Miura, H.Nakagawa, H.Ueshima, A.Okayama, S.Saitoh, JD.Curb, BL.Rodriguez, K.Sakata, N.Okuda, K.Yoshita,
J.Stamler, INTERMAP and INTERLIPID Research Groups: Dietary factors related to higher plasma fibrinogenlevels of Japanese-americans in hawaii compared with Japanerse in Japan, Arterioscler. Thromb. Vasc. Biol.,
26:1674-1679, 2006.

0240B011

M.Nishijo, Y.Morikawa, H.Nakagawa, K.Tawara, K.Miura, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Causes ofdeath and renal tubular dysfunction in residents exposed to cadmium in the environment, Occup Environ Med,
63:545-550, 2006.

0240B012(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose for renal dysfunction in a cadmium non-polluted area in Japan, J. Appl. Toxicol., 26:351-355,
2006.

0240B013(M.Uetani), E.Kobayashi, Y.Suwazaono, R.Honda, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Tissue cadmium(Cd) concentrations of people living in a Cd polluted area, Japan, Biometals, 19:521-525, 2006.

0240B014(Y.Fujieda), K.Miura, H.Nakagawa: Walking 10,000 steps per day is effective to improve coronary risk factors
among japaneses Middle-Aged Men, Jpn.J.Phys.Fitness Sports Med., 55(Suppl):S37-S42, 2006.

0240B015(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit variant C825T is a risk factor for hypertension in Japanese females -a prospective cohort
study over 5 years, Ann. Hum. Genet., 70:767-777, 2006.

0240B016

M.Ishizaki, N.Kawakami, R.Honda, H.Nakagawa, Y.Morikawa, Y.Yamada, The Japan Work Stress and HealthCohort Study Group: Psychosocial work characteristics and sickness absence in Japanese employees, Int. Arch.
Occup. Environ. Health., 79:640-646, 2006.

0240B017(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females,
Blood Press., 15:80-87, 2006.

0240B018(E.Kobayashi), Y.Suwazono, M.Uetani, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Tolerable level of lifetime
cadmium intake estimated as a benchmark dose low, based on excretion of β2-microglobulin in the cadmiumpolluted regions of the Kakehashi River Basin, Japan, Bull. Environ. Contam. Toxicol., 76:8-15, 2006.

0240B019(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, β２-microglobulin,
and N-acetyl-β-D-glucosaminidase in cadmium nonpolluted regions in Japan, Environ Res, 101:401-406, 2006.

0240B020(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: The 1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γglutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: aprospective cohort study over 5 years, Int. J. Mol. Med., 17:77-82, 2006.
－ 36 －

0240B021(T.Miyamoto), E.Kobayashi, Y.Suwazono, M.Uetani, M.Nishijo, K.Miura, H.Nakagawa, K.Nogawa: Changes inurinary excretions of cadmium, copper, and zinc in Japanese workers., Arch. Environ. Occup. Health., 61:251222, 2006.

0240B022

M.Nakashima, K.Miura, T.Sakai, M.Bansho, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Attiude to smoking
and effect of anti-smoking education in elementary school 6th grade students, Hokuriku Japanese Journal of Public
Health., 32:73-78, 2006 (in Japanese) .

0240B023

K.Miura, H.Myogadani, Y.Kadoya, M.Hayashi, M.Motoya, M.Kuzumaki, M.Yoneda, T.Mitsui, M.Nishijo,
Y.Morikawa, Y.Nakanishi, M.Nakashima, H.Nakagawa: Effectiveness of lifestyle modification programs for control ofblood pressure: A non-randomized controlled trial in Komatsu, Japan, Japanese Journal of Public Health., 53:533542, 2006 (in Japanese) .

Reviews
0240C001(S.Satarug), M.Nishijo, JM.Lasker, RJ.Edwards, MR.Moore: Kidney dysfunction and hypertension:role forcadmium,P450 and heme oxygenases?, Tohoku J. Exp. Med., 208:179-202, 2006.

Presentations at Conference
International Conference (Presentations)
0240I001

K.Miura, H.Nakagawa, H.Ueshima, A.Okayama, S.Saitoh, JD.Curb, B.Rodriguez, K.Sakata, N.Okuda, K.Yoshita,
J.Stamler: Dietary factors related to the plasma fibrinogen difference between Japanese in Japan and JapaneseAmericans in Hawaii: the INTERLIPID Study, 46th Annual Conference on Cardiovascular Disease Epidemiology
and Prevention, American Heart Association, (Phoenix, '06.03).

0240I002(K.Yoshita), K.Miura, N.Okuda, A.Okayama, S.Saitoh, H.Nakagawa, K.Sakata, S.Archer, P.Elliott, J.Stamler,
H.Ueshima, for the INTERMAP Research Group: Effects of dietary supplement use on average total micronutrient
intake in middle-aged Japanese: the INTERMAP Study, 46th Annual Conference on Cardiovascular Disease
Epidemiology and Prevention, American Heart Association, (Phoenix, '06.03).

0240I003

S.Yoneyama, K.Miura, S.Sasaki, S.Yoshita, M.Morikawa, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Relationship of dietary intake of fatty acids to serum C-reactive protein in Japanese, 14th International Symposium
on Atherosclerosis, (Rome, '06.06)，Atherosclerosis, 7:290, 2006.

0240I004

M.Nishijo, H.Nakagawa, R.Honda: A trial for a global standard health management for Cd pollution, Health risk
management for environment and labour, (Tokyo, '06.06)，URMPM special conference, 52, 2006.

0240I005

M.Ishizaki, Y.Morikawa, H.Nakagawa, R.Honda, N.Kawakami, T.Haratani, F.Kobayashi, S.Arai: Relationshipbetween change of job demand/control and absence from work, 28th International Congress on Occupational
Health, (Milan, '06.06)，Book of Abstracts, 292, 2006.

0240I006

M.Nishijo, H.Nakagawa, R.Naganuma, K.Tawara, T.Kido, H.Suzuki: An epidemiological study on health effects bydioxin in vietnam;conparison of contrast acuity between inhabitants of herbicide sprayed and non-sprayed areas,
26th International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0240I007

M.Nishijo, H.Nakagawa, Y.Morikawa, K.Tawara, J.Kuriwaki, E.Hori, H.Nishijo: Effect of 2,3,7,8thtrachlorodibenzo-p-dioxin exposure during pregnancy on the neurodevelopment of rat off-springs, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0240I008

M.Nishijo, H.Nakagawa, K.Tawara, T.Kido, R.Naganuma: Areal differences of concentration levels ofpolychlorinated debenzo-p-dioxins and dibenzofurans in human breast milk from Vietnam and Japan, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

－ 37 －

0240I009

K.Miura, H.Nakagawa, T.Kushiro, A.Takahashi, M.Nishinaga, H.Soejima, M.Taguri, R.Matsukawa, A.Harada,
Y.Ohashi, H.Ueshima, for the JALS Group.: Comparison of four blood pressure indexes in predicting stroke andmyocardial infarction: a meta-analysis of 15 cohort studies in Japan, 21th Scientific Meeting of the International
Society of Hypertension, (Fukuoka, '06.10)，J Hypertens, 24(suppl 6):S84, 2006.

0240I010(Q.Chan), J.Stamler, K.Miura, B.Zhou, P.Elliott: Relation of type, pattern of alcohol intake to blood pressure: the
INTERMAP Study, 21th Scientific Meeting of the International Society of Hypertension, (Fukuoka, '06.10)，J
Hypertens, 24(suppl 6):S57, 2006.

－ 38 －

0250

Department of Legal Medicine

Faculty
Title

Name

Professor

OHYA Isao

Field of Specialization

Keywords of Researchpersonal identification, chemical mediator, elastic recoil, aging, alveoler wall, postmortem changes－ 39 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

YASUDA Yukio

Associate Professor

AINODA Noriko

Associate Professor

HORI Ariyuki

Research Associate

KURODA Naohiro

Facultyundergraduate clinical teaching, graduate education of physicians,
medical education
medical education, educational assessment, problem-based learning,communication
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
medical informatics, electronic medical record system, medical
educatin

Keywords of Research
医学教育, 教育評価, 医療コミュニケーション, 臨床医学教育, 初期臨床教育, medical informatics, electronic recording,evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Reviews
0260C001(Y.Fujiwara), G.Henningsson, N.Ainoda: A review of japanese articles on perceptual assessment of speech sounds
in individuals with cleft palate, The Japan journal of logopedics and phoniatrics., 47:252-257, 2006.

0260C002

A.Hori: Education of subspecialty areas in graduate medical education, The Autonomic nervous system., 43:212217, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0260I001

H Kakinuma, M Itoh, H Takahashi, A Hori: REPETITIVE AXIAL MYOCLONUS IN A BOY WITH THE MCT8GENE MUTATION, 10th International Child Neurology Congress, (Montreal, '06.06)，Neuropediatrics,
26(Suppl.1):S97, 2006.

－ 40 －

Clinical
0300

Medicine

Department of Cardiovascular Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Kouji

Atherosclerosis, lipid metabolism

Professor(Additional Post)

MATSUI Shinobu

Heart failure

Associate Professor

TSUGAWA Hiroichi

Arrhythmia, Catheter ablation

Associate Professor

ASAJI Takayoshi

Heart failure

Associate Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Senior Assistant Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention

Senior Assistant Professor

UENISHI Hiroaki

Ischemic heart disease, Coronary intervention

Research Associate

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Research Associate

TAKEDA Kenji

Molecular Biology

Research Associate

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Research Associate

SATAKE Osamichi

Cardiomyopathy

Research Associate

SATO Ryoko

Ischemic heart disease, Coronary intervention

Research Doctor

ISHIDA Masaski

Hypertension

Research Doctor

KASENO Kenichi

Arrhythmia, Catheter ablation

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001

K.Kawaura: Analysis of thrombocyte counts and atherosclerosis-related markers in pre and post eradication of
Helicobacter pylori infection with chronic gastritis, J. Kanazawa. Med. Univ., 31:17-22, 2006 (in Japanese) .

0300B002

M.Wakasa: 3-Methylglutaconic aciduria (3MGA) in adult patients with left ventricular systolic dysfunction (LVSD),
J. Kanazawa. Med. Univ., 31:202-208, 2006 (in Japanese) .

0300B003

A.Motoyama: Plasma homocysteine and B vitamin and folate levels in male patients with coronary artery disease, J.
Kanazawa. Med. Univ., 31:23-29, 2006 (in Japanese) .
－ 41 －

Presentations at Conference
International Conference (Presentations)
0300I001

H.Akao, M.Kitayama, H.Uenishi, T.Kasuga, M.Asano, R.Sato, A.Motoyama, M.Wakasa, C.Kitaoka, K.Kajinami:
Similarity and difference between osteoprotegerin(OPG) and osteopontin(OPN) levels in patients receiving coronary
rotational atherectomy(RA), XIV International Symoisium on Atherosclerosis, (Rome, '06.06)，
ATHEROSCLEROSIS, 7:283, 2006.

0300I002

R.Sato, M.Okabayashi, H.Akao, K.Kajinami: Association between bone mineral density and atherosclerosis in
postmenopausal women, XIV International Symoisium on Atherosclerosis, (Rome, '06.06)，ATHEROSCLEROSIS,
7:411, 2006.

0300I003

H.Akao: LDL-apheresis may reduce coronary artery disease following percutaneous coronary intervention, 52NDANNUAL CONFERENCE CHICAGO, (CHICAGO, '06.06).

0300I004

S.Matsui: Specific removal of beta 1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune
cardiomyopathy improved cardiac structure and function, World Congress of Cardiology 2006, (Barcelona, '06.09).

－ 42 －

0310

Department of Respirolgy (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

lung physiology, sleep disordered breathing

Associate Professor

OSANAI Kazuhiro

lung cell and molecular biology , COPD

Senior Assistant Professor

HUANG Jyongsu

lung physiology, sleep disordered breathing

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine , pulmonary tuberculosis

Research Associate

SEKI Toshimitsu

clinical respiratory medicine

Research Associate

TOBE Takeyasu

clinical respiratory medicine

Research Associate

KASAKURA Hisato

clinical respiratory medicine

Research Associate

IGUCHI Masaharu

clinical respiratory medicine

Research Associate

TSUCHIHARA
Katsumaclinical respiratory medicine

Research Associate

OIKAWA Taku

clinical respiratory medicine , lung cancer

Research Associate

NAKAGAWA Kenclinical respiratory medicine , lung cancer

Research Doctor

TACHI Yuki

clinical respiratory medicine

Research Doctor

OIKAWA Rieko

clinical respiratory medicine , lung cancer

Keywords of Research
acute lung injury, cytokine, NO, matrix metalloproteinase, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic
reflection technique, upper airway compliance, CPAP, BiPAP, lung cancer, apoptosis, Fas, Fas ligand

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Apoptosis of lung cancer cells

Publications
Originals
0310B001

T.Sakuma, X.Gu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, K.Osanai, H.Toga, L.B.Ware, G.Folkesson,
M.A.Matthay: Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine, Crit.
Care Med., 34:676-681, 2006.

0310B002

J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami,
I.Yamamoto: Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lungadenocarcinomas, J. Nucl. Med., 47:419-425, 2006.

0310B003

M.Sagawa, K.Higashi, M.Sugita, Y.Ueda, S.Maeda, H.Toga, T.Sakuma: Fluorodeoxyglucose uptake correlates withthe growth pattern of small peripheral pulmonary adenocarcinoma, Surg Today, 36:230-234, 2006.

－ 43 －

0310B004

X.Gu, Z.Wang, J.Xu, S.Maeda, M.Sugita, M.Sagawa, H.Toga, T.Sakuma: Denopamine stimulates alveolar fluid
clearance via cystic flbrosis transmembrane conductance regulator in rat lungs, Respirology, 11:566-571, 2006.

0310B005(H.Kimura), H.Toga, H.Inoue, T.Iwanaga, N.Kohno, S.Hashimoto, Y.Hasegawa, N.Hizawa, M.Yamaya, M.Mishima:
A questionnaire report concerning the actual situation of respiratory physicians in Japan, The journal of theJapanese Respiratory Society., 44:312-318, 2006 (in Japanese) .

Reviews
0310C001

K.Osanai, C.Tsuchihara, R.Hatta, T.Oikawa, K.Tsuichihara, M.Iguchi, T.Seki, M.Takahashi, J.Huang, H.Toga:
Pulmonary surfactant transport in alveolar type Ⅱ cells, Respirology, 11:S70-S73, 2006.

Case Reports
0310D001

W.Chen, H.Kawahara, M.Takahashi, A.Matsushima, S.Takase: Marked pneumoperioneum 3 weeks after
percutaneous endoscopic gastrostomy, J. Gastroenterol. Hepatol., 21:919-921, 2006.

Presentations at Conference
International Conference (Presentations)
0310I001

J.Huang, K.Kojima, Y.Tachi, T.Fukunaga, K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai,
H.Toga: Expiratory flow limitation in the nasopharynx during wakefulness in patients with obstructive sleep apnea,
ATS 2006 International Conference, (San Diego, '06.05)，Proceeding of the Am.Thoracic Society, 3:A315, 2006.

0310I002

K.Osanai, R.Hatta, J.Higuchi, T.Miwa, H.Toga: Rab38-defficient rats show the phenotype of Hermansky-Pudlak
syndrome, 2006 FASEB Summer Conferences, (Coloradso, '06.08).

0310I003

K.Tsuchihara, K.Kojima, R.Hatta, Y.Tachi, T.Oikawa, K.Nakagawa, M.Iguchi, T.Tobe, T.Seki, M.Takahashi,
J.Huang, k.Osanai, H.Toga: Effect of sivelestat in patients with acute lung injury, ERS 2006, (Germany, '06.09)，
ERJ, 28:347S, 2006.

0310I004

R.Hatta, K.Osanai, M.Saito, Y.Machida, H.Kida, K.Kojima, Y.Tachi, K.Nakagawa, T.Oikawa, K.Tsuchihara,
M.Iguchi, T.Tobe, T.Seki, M.Takahashi, J.Huang, H.Toga, J.Higuchi: Lung changes caused by genetic disorder of
Rab 38 in lec/crj rat, 11th Congress of the Asian Pacfic Society of Respirology, (kyoto, '06.11)，Respirology,
11:A221, 2006.

0310I005

K.Osanai, R.Hatta, J.Higuchi, K.Tsuchihara, M.Iguchi, T.Seki, H.Toga, D.R.Volker: Rab 38 mutant mice
(chocolate) develop abnormal kinetics of lung surfactant and pulmonary emphysema, 11th Congress of the Asian
Pacfic Society of Respirology, (kyoto, '06.11)，Respirology, 11:A221, 2006.

0310I006

M.Iguchi, H.Kida, M.Saito, Y.Machida, K.Kojima, Y.Tachi, R.Hatta, K.Nakagawa, K.Tsuchihara, T.Tobe, T.Seki,
M.Takahashi, J.Huang, K.Osanai, H.Toga, M.Sagawa, T.Sakuma, Y.Ueda: Clinical evaluation of micropapillaryadenocarcinoma of the lung, 11th Congress of the Asian Pacific Society of Respirology, (kyoto, '06.11)，
Respirology, 11:A251, 2006.

0310I007

H.Toga, K.Tsuchihara, Y.Machida, M.Saito, K.Kojima, R.Hatta, Y.Tachi, T.Oikawa, K.Nakagawa, M.Iguchi,
T.Tobe, T.Seki, M.Takahashi, J.Huang, K.Osanai: Role of NO2 and NO3 in ventilator-induced lung injury, 11th
Congress of the Asian Pacific Society of Respirology, (Kyoto, '06.11)，Respirology, 11:A289, 2006.

0310I008

K.Kojima, J.Huang, H.Yamamura, T.Fukunaga, H.Kida, M.Saito, Y.Machida, Y.Tachi, R.Hatta, K.Nakagawa,
T.Oikawa, K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai, H.Toga: Compliance ofnasopharyngeal wall estimated by posterior rhinomanometry in patients with obstructive sleep apnea : comparison
with dynamic CT imaging, 11th Congress of the Asian Pacific Society of Respirology, (Kyoto, '06.11)，Respirology,
11:A203, 2006.

－ 44 －

0310I009

J.Huang, K.Kojima, T.Fukunaga, H.Kida, M.Saito, Y.Machida, Y.Tachi, R.Hatta, K.Nakagawa, T.Oikawa,
K.Tsuchihara, M.Iguchi, T.Tobe, T.Seki, M.Takahashi, K.Osanai, H.Toga: Influence of upper airway configuration
on lmpulse oscillometry measurement, 11th Congress of the Asian Pacific Society of Respirology, (Kyoto, '06.11)，
Respirology, 11:A224, 2006.

－ 45 －

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

TAKASE Shujiro

Gastroenterology, Hepatology

Associate Professor

KAWAHARA Hiromu Liver injury and oxidative stressResearch Associate

OKAMURA Hideyuki

Clinical featur and nutritional treatment of liver cirrhosis

Research Associate

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Research Associate

SHIMADA Masahiko

Clinical feature and pathogenesis of non-alcoholic steatohepatitis

Research Associate

SHIMANAKA Koshi

Clinical feature and treatment of viral hepatitis

Research Associate

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis

Research Associate

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Research Associate

TSUCHISHIMA
Mutsumi

Anti-virul therapy of viral hepatitis

Research Associate

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Research Associate

FUKURA Masayuki

Chemotherapy of advanced hepatic cancer

Faculty

Research Associate

YANO Hirokazu

Clinico-epidemiology of alcoholic liver injury

Research
Associate(Additional Post)

MATSUDA Makoto

Endoscopic treatment of esophageal varices

Research Doctor

ISHIZAWA Kiyohiro

Effect of alcohol in pathogenesis of esophageal cancer

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Genetic polymorphisms of alcoholic oxidizing enzymes in esophageal,pharyngeal and laryngeal cancer②Treatment for esophageal and gastric varices associated with portal
hypertension③Endoscopic treatment for early cancer of the esophagus, stomach and colon④Hepatic support system for severe alcoholic hepatitis⑤Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis－ 46 －

Publications
Originals
0320B001(M.Tsutsumi), J.George, K.Ishizawa, A.Fukumura, S.Takase: Effect of chronic dietary ethanol in the promotion of
N-nitrosomethylbenzylamine-induced esophageal carcinogenesis in rats, J. Gastroenterol. Hepatol., 21:805-813,
2006.

0320B002

M.Yamada, H.Kawahara, S.Takase: Expression of oxidative stress and antioxidant enzymes in experimental mousemodel of non-alcoholic steatohepatitis (NASH) developing hepatocellular carcinoma, J. Kanazawa. Med. Univ.,
31:223-232, 2006 (in Japanese) .

Reviews
0320C003

M.Shimada, S.Takase: Clinical feature of NASH, Nipponrinsho., 64:1114-1118, 2006 (in Japanese) .

0320C004

H.Kawahara, S.Takase: Mutation of mitochondrial DNA in patients with nonalcoholic steatohepatitis,
Nipponrinsho., 64:1095-1099, 2006 (in Japanese) .

Case Reports
0320D001

W.Chen, H.Kawahara, M.Takahashi, A.Matsushima, S.Takase: Marked pneumoperioneum 3 weeks after
percutaneous endoscopic gastrostomy, J. Gastroenterol. Hepatol., 21:919-921, 2006.

0320D002(H.Kawabata), T.Sawaki, T.Kawanami, K.Shimoyama, H.Karasawa, T.Fukushima, Y.Masaki, N.Ogawa, Y.Hirose,
K.Ozaki, K.Shimanaka, S.Takase, H.Ueno, H.Umehara: Myelodysplastic syndrome complicated with inflammatory
intestinal ulcers: significance of trisomy 8, Intern. Med., 45:1309-1314, 2006.

Presentations at Conference
International Conference (Presentations)
0320I001

M.Shimada, K.Ozaki, M.Fukura, H.Yano, M.Tsuchishima, H.Kawahara, S.Takase: Relationship between oligometricadiponectin and the progression of NASH, 57th American Association for the Study of Liver Disease, (Boston,'06.10)，Hepatology, 44(Suppl.1):651A-652A, 2006.

－ 47 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Associate Professor

ASAKA Mitsuhiro

Cellular immunity in uremia, Clinicopathological study of primary
nonfunction and chronic allograft nephropathy in renal transplantation

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology,

Research Associate

IMAMURA Hidetsugu Clinical nephrology,

Research Associate

ADACHI Hiroki

Clinical nephrology,

Research Associate

OKUYAMA Hiroshi

Clinical nephrology,

Research Associate

SAITOH Atsushi

Clinical nephrology,

Research Associate

SATO Kazutaka

Clinical nephrology,

Research Associate

CHIKAZAWA
Yoshihiro

Clinical nephrology,

Research Associate

NAKAGAWA Masaru Clinical nephrology,

Research Associate

HAYAMA Satoshi

Clinical nephrology,

Research Associate

MORITA Kyoko

Clinical nephrology,

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

－ 48 －

Publications
Originals
0330B001

I.Ishikawa, T.Hayama, S.Yoshida, M.Asaka, N.Tomosugi, M.Watanabe, H.Yamato, M.Sugano: Proteomic analysis of
rat plasma by SELDI-TOF-MS under the condition of prevention of progressive adriamycin nephropathy using oral
adsorbent AST-120, Nephron. Physiol., 103:125-130, 2006.

0330B002

I.Ishikawa, Y.Chikazawa, K.Sato, M.Nakagawa, H.Imamura, S.Hayama, H.Yamaya, M.Asaka, N.Tomosugi,
H.Yokoyama, K.Matsumoto: Proteomic analysis of serum, outflow dialysate and adsorbed protein onto dialysis
membranes (polysulfone and PMMA) during hemodialysis treatment using SELDI-TOF-MS, Am. J. Nephrol.,
26:372-380, 2006.

0330B003

N.Tomosugi, H.Kawabata, R.Wakatabe, M.Higuchi, H.Yamaya, H.Umehara, I.Ishikawa: Detection of serum
hepcidin in renal failure and inflammation by using ProteinChip System, Blood, 108:1381-1387, 2006.

0330B004(J.Yamahana), T.Wada, K.Furuichi, N.Sakai, H.Yokoyama, S.Kaneko: TAK-603, an anti-inflammatory compound,
reduces crescentic glomerulonephritis and preserves renal function in WKY rats, Nephrol. Dial. Transplant.,
21:2736-2744, 2006.

0330B005(N.Sakai), T.Wada, H.Yokoyama, M.Lipp, S.Ueha, K.Matsushima, S.Kaneko: Secondary lymphoid tissus chemokine(SLC/CCL21)/CCR7 signaling regulates fibrocytes in renal fibrosis, Proc. Natl. Acad. Sci. U.S.A., 103:1409814103, 2006.

0330B006(T.Wada), H.Azuma, K.Furuichi, N.Sakai, K.Kitagawa, Y.Iwata, K.Matsushima, S.Takahara, H.Yokoyama,
S.Kaneko: Reduction in chronic allograft nephropathy by inhibition of p38 mitogen-activated protein kinase, Am. J.
Nephrol., 26:319-325, 2006.

Case Reports
0330D001(Y.Iwata), T.Wada, A.Uchiyama, A.Miwa, I.Nakaya, T.Tohyama, Y.Yamada, T.Kurokawa, T.Yoshida, S.Ohta,
H.Yokoyama, H.Iida: Remission of IgA nephropathy after allogeneic peripheral blood stem cell transplantation
followed by immunosuppression for acute lymphocytic leukemia, Intern. Med., 45:1291-1295, 2006.

0330D002(K.Ohta), M.Shimizu, A.Nakai, T.Toma, Y.Kasahara, C.Arii, A.Yachie, T.Kawamura, A.Aikawa, A.Hasegawa,
K.Sato, H.Yokoyama, I.Ishikawa, S.Koizumi: Rituximab therapy for epstein-barr virus-related chronic hepatitis
following living donor kidney transplantation, Am. J. Kidney Dis., 48:986-989, 2006.

0330D003

T.Tanaka, M.Moriyama, T.Hayama, K.Suzuki: A case of ABO incompatible kidney transplantation complicated bypostoperative massive hemorrhage, Renaltransplantation･vascular surgery., 18:51-55, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0330I001

H.Yokoyama, S.Ohta, T.Wada: Glomerular lesions in preeclampsia can show every histologic variants of focal
segmental glomerulosclerosis, ASN 39th Annual Meeting, (San Diego, '06.11)，J.Am.Soc.Nephrol., 17:255A, 2006.

－ 49 －

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Professor

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterone secretion

Professor

UCHIDA Kenzo

endocrinology, hypertension and adrenal gland, diabetes

Associate Professor

NAKAGAWA Atsushi pancreatic and gut hormones, pituitary diseases

Senior Assistant Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Senior Assistant Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Research Associate

IMAIZUMI Noriko

intracellular mechanisms of aldosterone synthesis, diabetes

Research Associate

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Research Associate

FURUYA Keisuke

diabetes, thyroid diseases

Research Associate

MAEJIMA Katsuyuki

diabetes, thyroid diseases

Research Associate

KONISHI Kazunori

diabetes, arteriosclerosis

Research Associate

UEHARA Keigo

diabetes

Research
Associate(Additional Post)

KITADA Munehiro

diabetes, hypertension

Research Doctor
Research Doctor
Research Doctor

diabetes, thyroid diseases
ITO Hiroki

diabetes, thyroid diseases
diabetes, thyroid diseases

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

－ 50 －

Books
0340A007(K. Isshiki), D.Koya, M.Haneda: PPAR-γLigands and Diabetic Nephropathy, The Diabetic Kindney, 289-304,
Contenporary Diabetes, USA, 2006.

Publications
Originals
0340B001(M.Sakaguchi), M.Isono, K.Isshiki, T.Sugimoto, D.Koya, A.Kashiwagi: Inhibition of mTOR signaling with rapamycin
attenuates renal hypertrophy in the early diabetic mice, Biochem. Biophys. Res. Commun., 340:296-301, 2006.

0340B002(M.Omata), H.Taniguchi, D.Koya, K.Kanasaki, R.Sho, Y.Kato, R.Kojima, M.Haneda, N.Inomata: N-acetyl-serylaspartyl-lysyl-proline ameliorates the progression of renal dysfunction and fibrosis in WKY rats with establishedanti-glomerular basement membrane nephritis, J. Am. Soc. Nephrol., 17:674-685, 2006.

0340B003(S.Araki), M.Haneda, T.Sugimoto, M.Isono, K.Isshiki, A.Kashiwagi, D.Koya: Polymorphisms of the protein kinase
C-β gene (PRKCB1) accelerate kidney disease in type 2 diabetes without overt proteinuria, Diabetes Care.,
29:864-868, 2006.

0340B004(M.Tahara), M.Omatsu-Kanbe, M.Sanada, K.Maeda, D.Koya, H.Matsuura, A.Kashiwagi, H.Yasuda: Effect ofprotein kinase Cβ inhibitor on Ca2+ homeostasis in diabetic sensory neurons, Neuroreport., 17:683-688, 2006.

0340B005(K.Kanasaki), M.Haneda, T.Sugimoto, K.Shibuya, M.Isono, K.Isshiki, S.Araki, T.Uzu, A.Kashiwagi, D.Koya: Nacetyl-seryl-aspartyl-lysyl-proline inhibits DNA synthesis in human mesangial cells via up-regulation of cell cycle
modulators, Biochem. Biophys. Res. Commun., 342:758-765, 2006.

0340B006(S.Kume), M.Haneda, K.Kanasaki, S.Sugimoto, S-I.Araki, M.Isono, K.Isshiki, T.Uzu, K.Kashiwagi, D.Koya: Silent
information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation,
Free Radic. Biol. Med., 40:2175-2182, 2006.

0340B007(T.Uzu), G.Kimura, A.Yamauchi, M.Kanasaki, K.Isshiki, S.Araki, T.Sugiomoto, Y.Nishio, H.Maegawa, D.Koya,
M.Haneda, A.Kashiwagi: Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential
hypertension, J.Hypertens., 24:1627-1632, 2006.

0340B008(T.Uzu), T.Harada, M.Sakaguchi, M.Kanasaki, K.Isshiki, S.Araki, T.Sugiomoto, D.Koya, M.Haneda, A.Kashiwagi,
A.Kashiwagi, A.Yamauchi: Glucocorticoid-induced diabetes mellitus: prevalence and risk factors in primary renal
diseases, Nephron Clin. Pract., 105:c54-c57, 2006.

0340B009

K.Konishi: Determinant factors of the severity of carotid atherosclerosis in relation to accumulation of visceral fat
in type 2 diabetic subjects, J. Kanazawa. Med. Univ., 31:53-61, 2006 (in Japanese) .

－ 51 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology

Professor

HIROSE Yuko

Hematology and Immunology,Transfusion Medicine

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology

Senior Assistant Professor

MASAKI Yasufumi

Hematology and Immunology

Senior Assistant Professor

TANAKA Masao

Rheumatology,Immunology

Research Associate

KAWANAMI Takafumi Hematology and Immunology

Research Associate

JIN Zhexiong

Immunology

Keywords of Research
autoimmune disorder, SjÖgren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A) Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1) Effects of chemokines on
vascular injury and Th1 response during chronic inflammation. 2) Function of microdomain (lipid rafts) on lymphocyte
activation and its contribution in autoimmune diseases. 3) Analysis of immunological disorder in sphingomyelin knockout
mice. 4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5) Detection of stem cells insalivary glands and its implication for regenerative medicine.
B) Studies of hematological malignancies and development of anti-cancer drugs. 1) Analysis of EB-virus proteins and theirroles in lymphoproliferative disorders. 2) Molecular biological analysis of drug resistance. 3) Roles of sphingomyelin on
apoptosis.

Publications
Originals
0350B001

N.Tomosugi, H.Kawabata, R.Wakatabe, M.Higuchi, H.Yamaya, H.Umehara, I.Ishikawa: Detection of serum
hepcidin in renal failure and inflammation by using ProteinChip System, Blood, 108:1381-1387, 2006.

0350B002

L.Dong: Identification and characterization of novel human recombinant monoclonal fab fragments specific ｆor EBVviral capsid antigen established by phage display, J. Kanazawa. Med. Univ., 31:172-178, 2006.

0350B003

Y.Masaki, K.Itoh, T.Sawaki, H.Karasawa, T.Kawanami, T.Fukushima, H.Kawabata, Y.Wano, Y.Hirose, T.Suzuki,
S.Sugai, H.Umehara: Urinary pseudouridine in patients with lymphoma:Comparison with other clinical parameters,
Clin. Chim. Acta, 371:148-151, 2006.

0350B004(S.Goda), H.Inoue, H.Umehara, M.Miyaji, Y.Nagano, N.Harakawa, H.Imai, P.Lee, JB.Macarthy, T.Ikeo, N.Domae,
Y.Shimizu, J.Ida: Matrix metalloproteinase-1 produced by human CXCL12-stimulated natural killer cells, Am. J.
Pathol., 169:445-458, 2006.

－ 52 －

0350B005

Y.Hirose, Y.Masaki, T.Sawaki, K.Shimoyama, H.Karasawa, H.Kawabata, T.Fukushima, N.Ogawa, Y.Wano,
H.Umehara: Association of Epstein-Barr virus with human immunodeficiency virus-negative peripheral T-cell
lymphomas in Japan, Eur. J. Haematol., 76:109-118, 2006.

0350B006(H.Yoshifuji), T.Fujii, S.Kobayashi, Y.Imura, Y.Fujita, D.Kawabata, T.Usui, M.Tanaka, S.Nagai, H.Umehara,
T.Mimori: Anti-aminoacyl-tRNA synthetase antibodies in clinical course prediction of interstitial lung disease
complicated with idiopathic inflammatory myopathies, Autoimmunity, 39:233-241, 2006.

0350B007(F.Mizoroki): A phase Ⅱ syudy of VEPA/FEPP chemotherapy for aggressive lymphoma in elderly patients:Japan
Clinical Oncology Group Study JCOG9203, Int. J. Hematol., 83:55-62, 2006.

Reviews
0350C001

H.Umehara, M.Tanaka, T.Sawaki, Z.X.Jin, C.R.Huang, L.Dong, T.Kawanami, H.Karasawa, Y.Masaki,
T.Fukushima, Y.Hirose, T.Okazaki: Fractalkine in rheumatoid arthritis and allied conditions, Mod Rheumatol,
16:124-130, 2006.

Case Reports
0350D001

K.Shimoyama, N.Ogawa, T.Sawaki, H.Karasawa, Y.Masaki, H.Kawabata, T.Fukushima, Y.Wano, Y.Hirose,
H.Umehara: A case of Mikulicz's disease complicated with interstitial nephritis successfully treated by high-dose
corticosteroid, Mod Rheumatol, 16:176-182, 2006.

0350D002(H.Kawabata), T.Sawaki, T.Kawanami, K.Shimoyama, H.Karasawa, T.Fukushima, Y.Masaki, N.Ogawa, Y.Hirose,
K.Ozaki, K.Shimanaka, S.Takase, H.Ueno, H.Umehara: Myelodysplastic syndrome complicated with inflammatory
intestinal ulcers: significance of trisomy 8, Intern. Med., 45:1309-1314, 2006.

Presentations at Conference
International Conference (Presentations)
0350I001

K.Kitagawa, K.Hagihara, M.Fukuda, H.Sasaki, K.Shimoyama, K.Fujimoto, N.Ogawa, S.Sugai: Can lissamine green
replace rose bengal as the golden standard for Sjogren's syndrome diagnosis, IX International Symposium on
Sjogren's Syndrome, (Washington DC, '06.04).

0350I002

M.Tanaka, S.Ozaki, X-P.Tong, K.Murakami, D.Kawabata, T.Usui, T.Fujii, H.Umehara, T.Mimori: Cloning andanalysis of the receptor molecule for a novel arthritis-modifying factor,follistain-related protein(FRP)/TSC36/FSTL1, American College of Rheumatology 70th Annual Scientific Meeting, (Washington, D.C., USA, '06.11)，
Arthritis and Rheumatism, 2006.

－ 53 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology,Neuroimmunology,Clinical Immunology

Associate
Professor(Additional Post)

HORI Ariyuki

Senior Assistant Professor

MATSUI Masaru

Senior Assistant Professor

NAGAYAMA Shigeni

Clinical neurology,Neuroimmunology

Research Associate

NAGAISHI Akiko

Clinical neurology

Research Associate

NAKANISHI Megumi

Clinical neurology,Neuroimmuology

Research Associate

KAITO Muichi

Clinical neurology

Research Associate

GONDOU Yuichiro

Clinical neurology

Research Associate

ARAYA Shinichi

Neuroimmunology, Clinical Immunology

Medical education,Clinical neurology,Clinical sleep medicine,
Neurophysiology,Medical informatics
Neurology,Molecular biology Neuroimmunology,Cognitive
Neuroscience

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, sleep disorders, neuropathies, molecular genetics,
ischemic strokes, autoantibody, neuroinnunology, neuroinfection, expevimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be ellucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001

S.Saiki, K.Sakai, M.Saiki, Y.Kitagawa, T.Umemori, K.Murata, M.Matsui, G.Hirose: Varicose veins associated withCADASIL result from a novel mutation in the Notch3 gene, Neurology, 67:337-339, 2006.

Reviews
0360C001

M.Matsui: Clinicopathological aspects of multiple sclerosis, Advances in neurological sciences., 50：571-581, 2006
(in Japanese) .

Case Reports
0360D001

M.Nakagawa, K.Takeda, M.Yanagihara, H.Ishizaki, T.Mochizuki, T.Iura, S.Kataoka: A case of viper bite that
occurred during pregnancy, Nishinihon j. dermatol., 68：40-42, 2006 (in Japanese) .

0360D002

Y.Gondou, M.Kaito, M.Nakanishi, M.Matsui, M.Matsui, S.Kusunoki: A case of polymyositis associated with acutepolyradiculoneuritis, Peripheral nerve., 17：215-218, 2006 (in Japanese) .

－ 54 －

Presentations at Conference
International Conference (Presentations)
0360I001

H Kakinuma, M Itoh, H Takahashi, A Hori: REPETITIVE AXIAL MYOCLONUS IN A BOY WITH THE MCT8GENE MUTATION, 10th International Child Neurology Congress, (Montreal, '06.06)，Neuropediatrics,
26(Suppl.1):S97, 2006.

0360I002

M.Matsui, S.Araya, H.-Y.Wang, K.Ozawa, E.Nishiguchi, M.Matsui, M.Nakanishi, M.Kaito, Y.Gondo, T.Saida:
Percentage of CD4+CD25+cells in cerebrospinal fluid:a reliable immune parameter for disease activity in relapsingremitting multiple sclerosis, 8th International Society of Neuroimmunology Meeting, (Nagoya, '06.10).

0360I003

S.Nagayama, S.Miyake, T.Yamamura: Autoimmune Encephalomyelitis by Transfer of Lymphokine-activated Natural
Killer(NK)Cells., 8th International Congress of Neuroimmunology, (Nagoya, '06.10).

－ 55 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MATSUMOTO
Masayuki

Professor

MORIMOTO Shigeto

Geriatrics, Geriatric Cardiology, Geriatric Cerebrovascular Diease
Atherosclerosis, Echocardiology
Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Associate Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Senior Assistant Professor

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis

Senior Assistant Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

MIYAUCHI Eiji

Geriatrics, Diabetes Mellitus, Endocrinology

Senior Assistant Professor

MURAI Hiroshi

Geriatrics, Gastroenterology, Dementia, Nutrition

Research Associate

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Research Doctor

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis

Research Doctor

OWARI Masaki

Geriatrics, Hypertension, Atherosclerosis

Research Doctor

KATO Shouzaburo

Geriatrics, Hypertension, Atherosclerosis

Faculty

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

T.Takahashi, Y.Fei, Z.Shi-jie, J.Moriya, H.Sumino, S.Morimoto, N.Yamaguchi, T.Kanda: Beneficial effect ofbrewers' yeast extract on daily activity in a murine model o f chronic fatigue syndrome, eCAM, 3:109-115, 2006.

0370B002

T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda: Impaired
expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, Int. Heart J., 47:107-123, 2006.

0370B003

F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda:
Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, J.
Int. Med. Res., 34:297-302, 2006.
－ 56 －

0370B004

M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda: Angiotensin Ⅰconverting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans,
Hypertens. Res., 29:655-663, 2006.

0370B005

S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino,
M.Matsumoto: Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly
inpatients:effects of azelnidipine, Hypertens. Res., 29:943-949, 2006.

Reviews
0370C001

F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda:
Traditional chinese medicine and kampo: a review from the distant past for the future, J. Int. Med. Res., 34:231239, 2006.

Case Reports
0370D001

K.Sato, H.Murai, Y.Ueda, S.Katsuda: Intrahepatic sarcomatoid cholangiocarcinoma of round cell variant: a casereport and immunohistochemical studies, Virchows Arch., 449:585-590, 2006.

0370D002

H.Murai, S.Morimoto, I.Ohashi, K.Okaishi, H.Tsuchiya, K.Iwai, T.Nakahashi, Y.Nishimura, M.Okuro, E.Miyauchi,
T.Nojima, M.Matsumoto: A ninety-eight-year-old woman with ruptured pancreatic anaplastic mucinous
cystadenocarcinoma, Jpn. j. geriat., 43：246-251, 2006 (in Japanese) .

Others
0370F001(H.Honda), J.Iwahashi, T.Kashiwagi, Y.Imamura, N.Hamada, T.Anraku, S.Ueda, T.Kanda, T.Takahashi,
S.Morimoto: Outbreak of human metapneumovirus infection in elderly inpatients in japan, J. Am. Geriatr. Soc.,
54:177-180, 2006.

Presentations at Conference
International Conference (Presentations)
0370I001

S.Morimoto, T.Nakahashi, K.Okaishi, T.Takahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino,
M.Matsumoto: Hypotension induced by tilting of upper body in bedridden hypertensive elderly inpatients. Effectsof azelnidipine, The 21st scientific meeting of the international society of hypertension, (Fukuoka, '06.10).

0370I002

S.Morimoto, K.Okaishi, T.Nakahashi, Y.Saitoh, T.Nishino, M.Okuro, H.Murai, K.Nomura, M.Matsumoto:Comparisons of efficacies of olmesartan and telmisartan of elderly hypertensive sub, The 21st scientific meetting of
the international society of hypertension, (Fukuoka, '06.10).

0370I003

T.Nakahashi, S.Morimoto, M.Okuro, H.Murai, Y.Nishimura, K.Nomura, H.Tsuchiya, E.Miyauchi, K.Iwai,
M.Matsumoto: Relationship between sodium intake and cerebrovascular disease in japan, The 21st scientific
meetting of the international society of hypertension, (Fukuoka, '06.10).

0370I004

M.Okuro, S.Morimoto, T.Nakahashi, H.Murai, Y.Nishimura, K.Nomura, H.Tsuchiya, E.Miyauchi, K.Toba,
M.Matsumoto: Analysis of clinical factors that affect brain ischemic changes in the elderly, The 21st scientific
meetting of the international society of hypertension, (Fukuoka, '06.10).

0370I005(H.Honda), T.Takahashi, K.Nomura, Y.Imamura, N.Hamada, S.Morimoto: Outbreak of human metapneumovirus
infection in elderly inpatients in japan, The 5th east asian conference on infection control and prevention
EACIC2006, (Tokyo, '06.11).

0370I006

K.Nomura, H.Honda, T.Nakahashi, S.Morimoto, M.Matsumoto: Seroprevalence of human metapneumovirus inelderly inpatients in a japanese long-term care hospital, The 5th east asian conference on infection control andprevention EACIC2006, (Tokyo, '06.11).

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0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

TAKAHASHI Hiroaki Pediatric endocrinology

Professor

KOH Eikan

Pediatric cardiology

Associate Professor

KAKIMUMA Hiroaki

Pediatric neurology, Pediatric clinical genetics

Senior Assistant Professor

YANASE Takuya

Pediatric hematology, Pediatric nephrology

Research Associate

NAKAMURA
Tsuneyuki

Pediatric cardiology

Research Associate

KOBAYASHI Azusa

Neonatology

Research Associate

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Research Associate

ITO Masatsune

Pediatric endocrinology, Pediatric metabolism

Research Associate

YAMAMURA Junichi

Infectious disease in children, Moleculer biology

Research Associate

FUJIKI Takuma

Pediatric nephrology

Research Associate

SATO Hitoshi

Infectionus disease in children, Moleculer biology

Research Doctor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001

A Kobayashi, H Kakinuma, H Takahashi: Three novel and six common mutation in 11 patients with methylmalonicacidemia, Pediatr. Int., 48:1-4, 2006.

0380B002(S.Kageyama), DM.Agdamag, ET.Alesna, PS.Leano, AML.Heredia, IP.Abellanosa-Taq-An, LD.Jereza, T.Tanimoto,J.Yamamura, H.Ichimura: A natural inter-genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines, J.
Med. Virol., 78:1423-1428, 2006.

Reviews
0380C001

H.Kakimuma, E.Takase, M.Kita, M.Ozaki, H.Takahashi: Purpose of genetic testing and roles of genetic counseling,
J. Kanazawa. Med. Univ., 31:119-123, 2006 (in Japanese) .

－ 58 －

Case Reports
0380D001

H.Kakinuma, T.Fujiki, T.Nakamura, H.Takahashi: Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy
due to neonatal asphyxia, Pediatr. Int., 48:631-633, 2006.

0380D002

T.Akai, K.Yamamoto, H.Iizuka, S.Kawakami, J.Yoshida, H.Kakimuma, H.Yaguchi, T.Ozawa: Syndromic
craniosynostosis with elbow joint contracture, Pediatr Neurosurg, 42:108-112, 2006.

0380D003

E.Koh, A.Kobayashi, M.Matsuda, T.Nakamura, H.Takahashi: Fulminant complications of transient abnormal
myelopoiesis in two neonates with down's syndrome, The journal of the Japan Pediatric Society., 110:553-556,
2006 (in Japanese) .

0380D004

E.Koh, H.Sato, H.Takahashi: A case of kawasaki disease associated with an aseptic meningitis during intravenous
immunoglobulin therapy, Progress in Medicine, 26:1537-1540, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0380I001

H Kakinuma, M Itoh, H Takahashi, A Hori: REPETITIVE AXIAL MYOCLONUS IN A BOY WITH THE MCT8GENE MUTATION, 10th International Child Neurology Congress, (Montreal, '06.06)，Neuropediatrics,
26(Suppl.1):S97, 2006.

0380I002

C.Kitaoka, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Elevation ofbrain natriuretic peptitde in children with bronchial asthma attack., The First Asia-Pacific Congress of Pediatric
Cardiology and Cardiac Surgery, (Bangkok, '06.11).

0380I003

C.Akita, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Safety andEfficacy of Dexmedetomidine and low-dose Propofol combination for child cardiac catheterizations., The First
Asis-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, (Bangkok, '06.11).

－ 59 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

JIBIKI Itsuki

Associate Professor

ENOKIDO Fusako

Associate Professor

KUBOTA Takashi

Schizophrenia，Psychopharmacology，Epilepsy

Senior Assistant Professor

IWASAKI Shinzo

Psycho Physiology，Neuropsy Chology，Brain Imaging

Senior Assistant Professor

NAKAGAWA Haruo

Psycho Physiology，Psychotherapy，Senile Psychosis

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology，Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy，Clinical Psychology

Research Associate

ENATSU Igaku

Senile Psychosis

Research Associate

KAMEHIRO Maya

Psychosomatic Medison

Research Associate

KAMODA SachikofunctionalMRI，Epilepsy，Psychosomaticmedicine，
Chineseherbalmedicine

Research Associate

KOIZUMI Hazuki

Clinical Psychology，Cognitive-behaviora ltherapy

Research Associate

KOIWA Daisuke

Brain imaging，Schizophrenia

Research Associate

NANNO Hisatoshi

Schizophrenia

Research Associate

HIROYASU Kiwamu

Molecular Psychiatry，Schizophrenia, Epilepsy

Research Associate

ISHIKAWA Akira

Schizophrenia，Psychopharmacology

Faculty

Shizophrenia，Epilepsy，Brain imaging，Psychopharmacology，Senile
Demenｔia，Senile Psychosis
Child Psydiatry ，Psychopattalogy ，Psychosomatic Medison ，Liaison Psydsiatry

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001

A.Ishikawa: Increase of dopamine level in rabbit brain during clozapine-induced potentiation of excitatory synaptictransmission, J. Kanazawa. Med. Univ., 31：30-41, 2006 (in Japanese) .
－ 60 －

0390B002

T.Kawamura: Effects of olanzapine and aripiprazole on excitatory synaptic transmission, and dopamine andserotonin levels in the hippocampal dentate gyrus in the rabbit, J. Kanazawa. Med. Univ., 31:249-262, 2006 (inJapanese) .

Case Reports
0390D003

F.Enokido, T.Kubota, H.Nakagawa, K.Watanabe, M.Kamehiro, M.Ohara, I.Jibiki, M.Noda: Concepts and diagnoses
among neurasthenia, chronic fatigue syndrome (CFS) and depression: study of three cases with similar symptoms,
Japanese Society of Psychosomatic Medicine., 46：897-905, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0390I001

F.Enokido: Symptomatology of AD/HD considered from qualitative aspects of obsessive-compulsive and autistic
behaviours., 17th world Congress of the International Association of Child and Adolescent Psychiatry and Allied
Professions, (Melbourne Australia, '06.09).

0390I002

T.Kawamura, T.Kubota, A.Ishikawa, I.Jibiki: Effects of aripiprazole on dopamine and 5-HT function in rabbit brain,
19th ECNP CONGRESS, (Paris, '06.09).

0390I003

K.Hiroyasu, S.Kamoda, I.Jibiki: A case of DLB in which perospirone improved the symptoms of visual
hallucinations, The 6th Annual Meeting of International College of Geriatric Psychoneuropharmacology(ICGP),(Hiroshima, '06.10)，The 6th Annual Meeting of International College of Geriatric
Psychoneuropharmacology(ICGP), 115, 2006.

0390I004

K.Hiroyasu, I.Jibiki: Expression of Voltage-Gated Potassium Ion Channel Gene KCNQ3in Mouse Thymus, 6th
Asian ＆Oceanian Epilepsy Congress, (Malaysia, '06.11)，6th Asian ＆Oceanian Epilepsy Congress, 36, 2006.

0390I005

S.Kamoda, S.Iwasaki, I.Jibiki: Functional MRI Study on Memory Lateralisation in Normal Subject and Patients with
Partial Epilepsy, 6ｔｈ AOCE-KUALA LUMPUR 2006, (Malaysia, '06.11)，6th Asian ＆Oceanian Epilepsy
Congress, 44, 2006.

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0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

HIGASHI Kotaro

Oncologic Nuclear Medicine

Associate Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging

Senior Assistant Professor

OGUCHI Manabu

Radiation Therapy, Nuclear Medicine

Senior Assistant Professor

TANIGUCHI Mitsuru Cardiac Nuclear Medicine

Senior Assistant Professor

YOKOTA Hajime

Gastrointestinal Radiology, MR Spectroscopy

Senior AssistantProfessor(Additional Post)

KUGINUKI Yasuaki

Diagnostic Imaging

Research Associate

ARISAKA Yukiko

Nuclear Medicine

Research Associate

OOTA Kiyotaka

Radiation Therapy

Research Associate

NISHIKAWA Takahiro Nuclear Medicine, Diagnostic Imaging

Research
Associate(Additional Post)

YABUNO Yoshinori

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami,
I.Yamamoto: Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lungadenocarcinomas, J. Nucl. Med., 47:419-425, 2006.

0400B002

J.Guo: Tumor angiogenesis in lung adenocarcinomas : Correlation with FDG uptake and prognosis, J. Kanazawa.
Med. Univ., 31:10-16, 2006.

0400B003

M.Sagawa, K.Higashi, M.Sugita, Y.Ueda, S.Maeda, H.Toga, T.Sakuma: Fluorodeoxyglucose uptake correlates withthe growth pattern of small peripheral pulmonary adenocarcinoma, Surg Today, 36:230-234, 2006.

－ 62 －

0400B004

T.Takahashi: FDG uptake within the primary tumor, HRCT findings and serum level of CEA as predictors ofrecurrence in patients with surgically resected lung adenocarcinoma smaller than 3 cm, J. Kanazawa. Med. Univ.,
31:185-193, 2006 (in Japanese) .

0400B005

K.Kai: Experimental study of radiation-induced lung injury after unilateral hith single-dose irradiation, J.
Kanazawa. Med. Univ., 31:424-248, 2006 (in Japanese) .

0400B006

M.Matoba, T.Kondou, T.Nishikawa, Y.Kuginuki, H.Yokota, K.Higashi, H.Tonami: Efficacy of high iodine
concentration contrast medium with saline pushing in hepatic CT in patients with chronic liver disease; comparisonof high doses-standard contrast medium concentration, Jpn. j. clin. Radiol., 51：1851-1856, 2006 (in Japanese) .

Case Reports
0400D001

K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda:
Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, J. Int. Med. Res., 34:437440, 2006.

0400D002

Z.Wang, X.Jin, Y.Machida, H.Aikawa, M.Sagawa, K.Higashi, H.Saito, T.Kosaka, S.Takashima, T.Sakuma:
Colorectal cancer identified by FDG-PET during preoperative axamination for lung cancer: report of two cases, J.
Kanazawa. Med. Univ., 31:144-146, 2006.

0400D003

M.Sugita, M.Sagawa, Y.Ueda, K.Higashi, T.Sakuma: Localized bronchioloalveolar carcinoma with small foci ofactive fibroblastic proliferation, Respiration, 73:694-697, 2006.

－ 63 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUBARA Junichi Vascular surgery

Professor

SAKAMOTO Shigeru

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery, Respiratory surgery

Associate Professor

HIDA Kenji

Vascular surgery

Senior Assistant Professor

TSUCHISHIMA Shuji

Senior Assistant Professor

NAGAYOSHI Yasuhiro Cardiovascular surgery

Senior Assistant Professor

NISHIZAWA Hisateru Cardiovascular surgery

Senior Assistant Professor

TAKEUCHI Katsunori

Research Associate

KANNO Masaaki

Cardiovascular surgery

Research Associate

KOBATA Takashi

Vascular surgery

Research Associate

NONAKA Toshimichi Cardiovascular surgery

Research Associate

NOGUCHI Yasuhisa

Cardiovascular surgery

Research Doctor

MIZUNO Fumito

Vascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Publications
Originals
0410B001

K.Hida, M.Hiramatsu, K.Atsumi, Y.Noguchi, T.Kobata, H.Shikata, S.Sakamoto, J.Matsubara: Efficacy ofendoscopic thoracic sympathectomy－intraoperative assessment using near-infrared spectroscopy, The journal ofJapanese College of Angiology., 46：45-48, 2006 (in Japanese) .

0410B002

J.Kiyosawa: Evaluation of sympathetic nerve activity by fluctuation analysis of a finger tip blood flow pulse wave
and its clinical application, J. Kanazawa. Med. Univ., 31:194-201, 2006 (in Japanese) .

－ 64 －

Case Reports
0410D001

H.Shikata, K.Miyazawa, Y.Ueda, T.Kobata, K.Hida, J.Matsubara: A case of synchronous renal cell carcinoma
producing granulocyte colony stimulating factor(G-CSF) and abdominal aortic aneurysm, Jpn. J. Cardiovasc.Surg.,
15:521-524, 2006.

0410D002

K.Sato, Y.Ueda, H.Shikata, S.Katsuda: Bronchioloalveolar carcinoma of mixed mucinous and nonmucinous type:
Immunohistochemical studies and mutation analysis of the p53 gene, Pathol. Res. Pract., 202:751-756, 2006.

0410D003

S.Sakamoto, J.Matsubara, Y.Nagayoshi, H.Nishizawa, K.Takeuchi, J.Kiyosawa: Annular reconstruction for mitralvalve replacement in a destroyed or calcified mitral annulus, Jpn. J. Thorac. Cardiovasc. Surg., 54:500-503, 2006.

0410D005

H.Shikata, K.Kurose, T.Kobata, K.Hida, M.Moriyama, N.Morita, S.Sakamoto, K.Suzuki, J.Matsubara: Surgicaltreatment of abdominal aortic aneurysm accompanied by bilateral large multicystic kidneys, The Japanese Society
for Cardiovascular Surgery., 35：251-254, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0410I001

K.Hida, T.Kobata, H.Shikata, S.Sakamoto, J.Matsubara: Surgical strategies for patients with abdominal aortic
aneurysm who are suffering from ischemic heart disease, 7th International Congress of the Asian Society for
Vascular Surgery, (Malaysia, '06.08).

0410I002

T.Kobata, K.Hida, H.Shikata, S.Sakamoto, J.Matsubara: One year follow-up after endovenous radiofrequency
obliteration of the great saphenous vein-air plethysmographic examinations of the effect, The 4th Meeting of theJapanese German Society for Vascular Surgery, (Nuremberg, '06.08).

0410I003

H.Shikata, T.Kobata, K.Hida, S.Sakamoto, J.Matsubara: Endvascular treatment using carbondioxide angiography,
The 4th Meeting of the Japanese German Society for Vascular Surgery, (Nuremberg, '06.08).

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0420

Department of Surgical Oncology

Title

Name

Field of Specialization

Professor

TAKASHIMA Shigeki

Surgical treatment of gastrointestinal cancer - especially gastriccancer and colorectal cancer

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Senior Assistant Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

YOSHITANI Shinichiro Surgery of colorectal cancer

Research Associate

USAMI Kazuo

Surgery of digestive disease

Research Associate

SUGAYA Junichi

Surgery of gastric cancer

Research Associate

TANAKA Yumiko

Surgery of colorectal cancer

Research Associate

HASEGAWA Taisuke Surgery of hepatobiliary diseases

Research Associate

MUKAI Hirokado

Research Associate

YOKOI Miki

Research Associate

KURODA Masatoshi

Faculty

Surgery of digestive disease

Surgery of colorectal cancer

Keywords of Research
gastric cancer, lymph node metastasis, colorectal cancer, hepatic metastasis, hepatic resection, pancreas cyst, cystic
tumor, interleukin 6, biliary drainage, cytokine, laparoscopic cholecystectomy, choledocholithiasis, chemotherapy,
biochemical modulation, hepatolithiasis, pancreatic injury, bile duct cancer, pancreatic cancer, panperitonitis, gallbladdercancer, tumor marker, duodenal cancer, pancreaticoduodenectomy, abdominal injury, esophageal acharasia, neoadjuvant
chemotherapy, multiple organ injury, ileus, pancreatitis, breast cancer

Outline of Research①Study on caricinogenesis of gastrointestinal cancer②Treatment of peritonitis carcinomatosa③Strategy for hematogenous metastasis④Study on usefulness of Endotoxin adsorption therapy (PMX-DHP) for acute diffuse peritonitis accompanying large
intestinal perforation⑤Clinical evaluation of reconstructive method after gastrointestinal operation

Publications
Originals
0420B001

T.Kosaka, K.Usami, N.Ueshige, T.Hasegawa, S.Yoshitani, J.Sugaya, Y.Nakano, S.Takashima: Paraaortic lymph
node dissection for gastric cancer in 244 consecutive cases, Hepatogastroenterology, 53:629-633, 2006.

0420B002

H.Saito, M.Kuroda, K.Matsuzawa, Y.Tanaka, T.Hasegawa, S.Yoshitani, T.Kosaka, S.Takashima: The usefulness
and limitations of PMX-DHP for the treatment of SIRS caused by perforation in the large intestine, Jornal of Japan
Society for Surgical Infection., 3:93-100, 2006 (in Japanese) .

－ 66 －

0420B003

K.Hayashi, S.Takashima: Citrus auraptene suppresses azoxymethane-induced colon carcinogenesis in mice, J.
Kanazawa. Med. Univ., 31:216-222, 2006 (in Japanese) .

Case Reports
0420D001

Z.Wang, X.Jin, Y.Machida, H.Aikawa, M.Sagawa, K.Higashi, H.Saito, T.Kosaka, S.Takashima, T.Sakuma:
Colorectal cancer identified by FDG-PET during preoperative axamination for lung cancer: report of two cases, J.
Kanazawa. Med. Univ., 31:144-146, 2006.

0420D002

K.Sato, Y.Ueda, M.Yokoi, K.Hayashi, T.Kosaka, S.Katsuda: Reactive lymphoid hyperplasia of the liver in a patientwith multiple carcinomas: a case report and brief review, J. Clin. Pathol., 59:990-992, 2006.

0420D004

T.Hasegawa, S.Yoshitani, H.Saito, T.Kosaka, S.Takashima: Nodular cholangiocellular carcinoma arising in S4 withpapillary involvement of the extrahepatic biliary tree－A case report－, The Journal of the Japanese Practical
Surgeon Society., 67:1380-1385, 2006 (in Japanese) .

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0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Associate Professor

OKADA Masato

Peripheral nerve surgery, Trauma

Senior Assistant Professor

FUJITA Takuya

Spinal surgery

Senior Assistant Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

YOKOYAMA
Mitsuteru

Hand surgery, Trauma

Senior Assistant Professor

OKUDA Tetsuhito

Spinal surgery

Senior Assistant Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Senior Assistant Professor

MAEOKA Hayato

TraumaResearch Associate

OGASAWARA
Masataka

Hip surgery

Research Associate

NOUTOMI Kenji

Joint surgery

Research Associate

HOSOKAWA Hidetaka Spinal surgery

Research Associate

ICHISEKI Toru

Hip surgery

Research Associate

KITAMURA Kenji

Hip surgery

Research Associate

HATANO Eiju

Spinal surgery

Research Associate

HIROMURA Kentaro

TraumaResearch Associate

FUKUI Kiyokazu

Hip surgery

Research Associate

YASUDA Yoshihito

Spinal surgery

Research Associate

YAMADA Kengo

Hip surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we have been trying to elucidate the mechanism of degeneration of lumber disc. It has been reported that
apoptosis of vertebral disc cells occurs in the degenerative intervertebral disc. However, its molecular mechanism remains
to be defined. The gene expression of Bax and Bcl-2 was analyzed in degenerative intervertebral disc. As a result,mechanical stress of the disc induces apoptosis through a Bax, reducing the number of cells and the synthesis ofextracelular matrix proteins and resulting in the degeneration of the disc.
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Publications
Originals
0430B001

T.Ichiseki, Y.Ueda, S.Katsuda, K.Kitamura, A.Kaneuji, T.Matsumoto: Oxidative stress by glutathione depletioninduces osteonecrosis in rats, Rheumatology (Oxford), 45:287-290, 2006.

0430B002

K.Fukui, R.Kominami, H.Shinohara, T.Matsumoto: Glucocorticoid induces micro-fat embolism in the rabbit: A
scanning electron microscopic study, J. Orthop. Res., 24:675-683, 2006.

0430B003

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, K.Yamada, T.Matsumoto: The relationship between stem subsidence
and improvement in the radiolucency in polished tapered stems, Int Orthop, 30:387-390, 2006.

0430B004

E.Hatano, T.Fujita, Y.Ueda, T.Okuda, S.Katsuda, Y.Okada, T.Matsumoto: Expression of ADAMTS-4(aggrecanase-1) and possible involvement in regression of lumbar disc herniation, Spine, 31:1426-1432, 2006.

0430B005(K.Hirosaki), K.Shintani, A.Kaneuji: Study on high speed cutting of bio-titanium alloy － Tool wear pattern andmechanism of binder-less PcBN tool －, Journal of the Japan Society for Precision Engineering Supplement
Contributed papers., 72：219-223, 2006 (in Japanese) .

0430B008

T.Fujita, T.Okuda, E.Hatano, Y.Yasuda, T.Matsumoto: Posterior cervical herniotomy using METRx Micro
Discectomy system for cervical disc herniation, Surgical Technique for Spine and Spinal Nerves., 8:75-78, 2006 (inJapanese) .

0430B009

K.Yamada, A.Kaneuji, K.Hirosaki, M.Takano, T.Matsumoto: Biomechanical effects of the different surface finish of
cement-fixed femoral stems on bone cement, Nippon rinsho Japanese Journal of Clinical Biomechanics., 27:275280, 2006 (in Japanese) .

0430B012

A.Kaneuji, K.Yamada, K.Hirosaki, M.Takano, T.Matsumoto: Compressive force and cement creep at the cementbone interface in polished tapered stems fixed with vacuum-mixd cement, Nippon rinsho Japanese Journal of
Clinical Biomechanics., 27:281-285, 2006 (in Japanese) .

0430B013

K.Miaki: Osteonecrosis induction using an oxidative stress inducer in Japanese white rabbits, J. Kanazawa. Med.
Univ., 31:179-184, 2006 (in Japanese) .

0430B014(K.Hirosaki), K.Shintani, H.Kato, A.Kaneui: High ｓpeed milling of bio-titanium alloys using a binder-less PcBN
tool - Tool damage mechanism of flank face in machining of β type alloy-, Journal of the Japan Society for
Precision Engineering Supplement Contributed papers., 72：1397-1401, 2006 (in Japanese) .

Others
0430F001

T.Ichiseki, A.Kaneuji, K.Kitamura, T.Matsumoto: Does oxidative stress play a role in steroid-induced
osteonecrosis models?, Med. Hypotheses., 66:1048, 2006.

0430F002

T.Ichiseki, T.Matsumoto: Oxidative stress may underlie the sex differences seen in steroid-induced osteonecrosis
models, Med. Hypotheses., 66:1256, 2006.

Presentations at Conference
International Conference (Presentations)
0430I001

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Yamada, K.Fukui, T.Matsumoto: A minimum 10 year result of HGP I cups
without bulk bone graft for Crowe group I to Ⅲ acetabuli, American Academy of Orthopaedic Surgeons 2006
Annual Meeting (AAOS 2006), (Chicago, '06.03).

0430I002

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Yamada, K.Fukui, K.Kitamura, T.Matsumoto: A minimum 10 year outcome
study of Harris/Galante Porous I cups without bulk bone graft for Crowe group I to Ⅲ acetabuli, 5th Hip Section
Meeting of the Asia Pacific Orthopaedic Association (Hip-APOA 06), (Adeilaide, '06.05).

－ 69 －

0430I003

K.Hiromura, M.Okada, K.Noutomi, A.Kaneuji, T.Nishisaka, T.Matsumoto: The effects of Q-Switched Nd:YAG
laser irradiation on fracture healing in rats, The 10th Conference of the International Society for Fracture Repair(ISFR), (Adeilaide, '06.05).

0430I004

K.Yamada, A.Kaneuji, K.Hirosaki, M.Takano, T.Matsumoto: Biomechanical effects of the different surface finish of
cement-fixed femoral stems on bone cement, 5th Hip Section Meeting of the Asia Pacific Orthopaedic Association(Hip-APOA 06), (Adeilaide, '06.05).

0430I005

A.kaneuji: The effects of polished and rough stems on the cement-bone interface, 5th Asia Pacific Orthopaedic
Symposium 2006 (APOS), (Singapore, '06.08).

0430I006

T.Fujita, Y.Yasuda, H.Hosokawa, E.Hatano, T.Okuda, T.Matsumoto: Involvement of Bax-Mediated apoptosis indegenerative intervertebral disc, North American Spine Society 21st Annual Meeting, (Seattle, '06.09).

0430I007

A.Kaneuji, K.Yamada, K.Hirosaki, M.Takano, T.Matsumoto: Biomechanical differences at the cement-boneinterface of polished and roughened tapered stems cemented in composite femurs, ISTA 2006―9th Annual
Symposium, (New York, '06.10).

0430I008

T.Sugimori, KG.Vince, A.Abdeen: Efficacy of using tibial offset stem in revision knee arthroplasty, ISTA 2006―9th
Annual Symposium, (New York, '06.10).

－ 70 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Associate Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Associate Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease

Senior Assistant Professor

TAKADA Hisashi

crebrovascular disease, head injury, interventional neurosurgery

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Research Associate

SASAGAWA Yasuo

brain tumor

Research Associate

SIRAGA Syunsuke

general neurosurgery

Research Associate

PARK Cheho

spinal disease

Research Associate

MURASAKA Kenshi

general neurosurgery

Research Associate

YAMAMOTO Kenji

general neurosurgery

Research Associate

YAMAMOTO Jiro

general neurosurgery

Research Doctor

TORIGOE Keiichiro

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia－ 71 －

4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001

T.Akai, H.Iizuka, S.Kawakami: Treatment of craniosynostosis by distraction osteogenesis, Pediatr Neurosurg,
42:288-292, 2006.

Case Reports
0440D001

T.Akai, K.Yamamoto, T.Iida, H. Iizuka, T.Nojima: Malignant fibrous histiocytoma in the craniocervical junction
presenting with severe occipitalgia, Brain Tumor Pathol., 23:101-105, 2006.

0440D002

T.Akai, K.Yamamoto, H.Iizuka, S.Kawakami, J.Yoshida, H.Kakimuma, H.Yaguchi, T.Ozawa: Syndromic
craniosynostosis with elbow joint contracture, Pediatr Neurosurg, 42:108-112, 2006.

0440D003

Y.Sasagawa, T.Sasaki, T.Fuji, T.Akai, H.Iizuka: Ventriculoperitoneal shunt malfunction due to pregnancy,
Neurological surgery., 34:181-187, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0440I001

T.Akai, T.Iida, H.Iizuka, S.Okamoto, M.Kohno, H.Ikawa: Diagnosis and treatment of currarino anomaly, 34th
Annual meeting of the international society for pediatric neurosurgery, (Taipei, '06.09).

－ 72 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Senior Assistant Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

YOSHIDA Jun

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Research Associate

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Research Associate

KOMURO Akito

Plastic and Reconstructive Surgery

Research Associate

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Research Associate

KUROSAWA Tomoko Plastic and Reconstructive Surgery

Research Associate

HIMI Yuji

Plastic and Reconstructive Surgery

Research Associate

IMOTO Toshhihiro

Plastic Surgery

Research Associate

SHINOKAWA Yasuo

Plastic Surgery

Research Associate

YAMASHIRO Kaori

Plastic Surgery

Research Associate

ENOMOTO Jin

Plastic Surgery

Research Associate

HARASHIMA Youto

Plastic Surgery

Research Associate

MORITA Reiji

Plastic and Reconstructive Surgery

Research Associate

MIYASHITA Matsuki

Plastic Surgery

Research Associate

YASUDA Junko

Plastic Surgery

Research Associate

SATSUKI Reikoplastic surgery

Research Associate

NISHIKAWA Yuuki

plastic surgery

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery－ 73 －

New operative procedures in cranio-maxillo-facial fields are attempted to develope.

Publications
Originals
0450B001

T.Akai, H.Iizuka, S.Kawakami: Treatment of craniosynostosis by distraction osteogenesis, Pediatr Neurosurg,
42:288-292, 2006.

0450B002

R.Satsuki, S.Kawakami: The treatment of the combination therapy using artificial dermis and bFGF with intractableulcers, Skin research., 5：46-51, 2006 (in Japanese) .

0450B003

Y.Yamamoto, S.Kawakami, M.Kishibe, K.Shimada: The combination effects of hydrogel dressing (Viewgel®） andpolyurethane film dressing (Cathereep®） on split-thickness skin donor sites, Journal of new remedies & clinics.,
55：967-976, 2006 (in Japanese) .

0450B004

Y.Yamamoto, S.Kawakami: A basic strategy for the treatment of burn wounds in infants and children, The Japanesejournal of plastic & reconstructive surgery., 49:849-857, 2006 (in Japanese) .

0450B005

M.Kishibe, S.Kawakami, M.Nozaki, N.Isono, K.Harii, T.Moriguchi, K.Yamada: Clinical effects ofcarboxymethylcellulose (AQUACEL®） for the treatment of partial thickness burns, Japanese journal of burninjuries., 32：249-257, 2006 (in Japanese) .

0450B006

H.Yasuda: Comparative study of skin tissue reactions after hyaluronic acid or collagen injection, J. Kanazawa.
Med. Univ., 31:233-241, 2006 (in Japanese) .

Case Reports
0450D001

T.Akai, K.Yamamoto, H.Iizuka, S.Kawakami, J.Yoshida, H.Kakimuma, H.Yaguchi, T.Ozawa: Syndromic
craniosynostosis with elbow joint contracture, Pediatr Neurosurg, 42:108-112, 2006.

Presentations at Conference
International Conference (Synposium)
0450H001

J.Yoshida, S.Kawakami, Jun Jennifer N Keagle,, Henry K Kawamoto: Contour reconstruction of the face using fat
injection, The 16th Japan-China Joint Meeting on Plastic Surgery, (Harbin, China, '06.08).

International Conference (Presentations)
0450I001

A.Komuro, K.Shimada, M.Kishibe, Y.Yamamoto, M.Yamashita, S.Kawakami: Treatment for Burn Wounds using
Basic Fibroblast Growth Factor Spray, Burn and Wound Care Symposium, (Maui,Hawaii, '06.02).

0450I002

M.Kishibe, A.Komuro, K.Shimada, J.Yoshida, S.Kawakami: Treatment for Burn Wounds using basic fibroblast
growth factor spray, The 16th Japan-China Joint Meeting on Plastic Surgery, (Harbin, China, '06.08).

0450I003

K.Shimada, A.Nishio, R.Morita, Y.Himi, S.Kawakami: Clinical strategy for skin fistula after craniotomy, The 16th
Japan-China Joint Meeting on Plastic Surgery, (Harbin, China, '06.08).

0450I004

Liangliang Quan, R.Morita, K.Shimada, S.Kawakami: Facial protection masks after fracture treatment of the nasal
bone to prevent reinjury in contact sports, The 16th Japan-China Joint Meeting on Plastic Surgery, (Harbin,
China, '06.08).

0450I005

J.Yoshida, S.Kawakami, Jennifer N Keagle, Henry K Kawamoto: Contour reconstruction of the face using fat
injection, The 8th Japan-Korea Congress of Plastic and Reconstructive Surgery, (Jeju,Korea, '06.09).

0450I006

Y.Himi, A.Nishio, R.Morita, K.Shimada: Clinical Strategy for the Cranial Skin Fistula after Craniotomy, The 8thJapan-Korea Congress of Plastic and Reconstructive Surgery, (Jeju,Korea, '06.09).
－ 74 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Associate Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Senior Assistant Professor

KONUMA Kunio

Pediatric surgery, Anorectal malformations, Pediatric laringo tracheo
surgery

Senior Assistant Professor

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Research Associate

FUKUMOTO Yasunori Pediatric surgery

Research Associate

MORIMURA Eri

Faculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

K.Konuma, H.Ikawa, M.Kohno, S.Okamoto, H.Masuyama, H.Hukumoto: Sexual problems in male patients older
than 20 years with anorectal malformations, J. Pediatr. Surg., 41306-309, 2006.

0460B002

Y. Inoue, T. Shinka, M. Ohse, H. Ikawa, T. Kuhara: Application of optical isomer analysis by diastereomer
derivatization GC/MS to determine the condition of patients with short bowel syndrome, J. Chromatogr. B Analyt.
Technol. Biomed. Life Sci., 838:37-42, 2006.

0460B003

M.Kohno, Y.Fukumoto, H.Masuyama, S.Okamoto, H.Ikawa: Clinical defecation functiof transanal endorectal pullthrough for hirschsprung's disease: comparison with the open procedure (Z-Shaped Anastomosis), Journal of theJapanese Society of Pediatric Surgery., 42:181-187, 2006 (in Japanese) .

Reviews
0460C001

H.Masuyama, H.Ikawa, Y.Fukumoto, S.Okamoto, K.Konuma, M.Kohno: Extended dissection based on the anatomyof the portahepatis for biliary atresia, Japanese journal of pediatric surgery ; Shoni geka., 38:870-873, 2006 (inJapanese) .

－ 75 －

Presentations at Conference
International Conference (Presentations)
0460I001

M,Kohno, H,Ikawa, H,Hukumoto, S,Okamoto, H,Masuyama, K,Konuma: Clinical Outcome and Colonic Manometryin Children after Transanal Endorectal Pull-Through for Hirschsprung's Disease, British Association of Paediatirc
Surgeons 53rd Annual International Congress Stockholm, (Sweden, '06.07).

0460I002

T.Akai, T.Iida, H.Iizuka, S.Okamoto, M.Kohno, H.Ikawa: Diagnosis and treatment of currarino anomaly, 34th
Annual meeting of the international society for pediatric neurosurgery, (Taipei, '06.09).

0460I003

H.Masuyama: Is transanal endorectal pull through beneficial for colonic motility on defecation, 20th Congress ofAsian Associationof Pediatric Surgeons(AAPS), (India, '06.11).

－ 76 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis.

Professor

NAKAIZUMI Hiroko

Associate Professor

KITAGAWA Kazuko

Senior Assistant Professor

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration.

Research Associate

NAGAI Kouta

cataract, epidemiology,

Research Associate

KAWAKAMI Yutaka

cataract, thyroid ocular.

Research Associate

FUJITA Nobuyuki

uveitisResearch Associate

SHIMA Ichiroocular infection

Research Associate

HAGIWARA Kenta

ocular infection

Research Doctor

NAKANO Tarou

cataract

Research Doctor

YAGUCHI Hiromoto

corneal epithelium, glsucoma.

intraocular lens, strabismus amblyopia, blepharospasm, pediatric
ophthalmology.
ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics.
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 77 －

Publications
Originals
0470B001(T.Takata), T.Shimo-Oka, M.Kojima, K.Miki, N.Fujii: Differential analysis of D-β-Asp- containing proteins foundin normal and infrared irradiated rabbit lens, Biochem. Biophys. Res. Commun., 344:263-271, 2006.

0470B002(A.Arnarsson), T.Sverrisson, E.Stefansson, H.Sigurdsson, H.Sasaki, K.Sasaki, F.Jonasson: Risk factors for fiveyear incident age-related macular degeneration: The Reykjavik Eye Study, Am. J. Ophthalmol., 142:419-428,
2006.

0470B003(GM.Zoega), A.Fujisawa, H.Sasaki, A.Kubota, K.Sasaki, K.Kitagawa, F.Jonasson: Prevalence and risk factors forcornea guttata in the Reykjavik Eye Study, Ophthalmology, 113:565-569, 2006.

0470B004(A.Hirata), S.Watanabe, M.Kojima, I.Hata, K.Wake, M.Taki, K.Sasaki, O.Fujisawa, T.Shiozawa: Computationalverification of anesthesia effect on temperature variations in rabbit eyes exposed to 2.45 GHz microwave energy,
Bioelectromagnetics, 27:602-612, 2006.

0470B005(A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa: Temperature elevation in the eye ofJapanese male and female models for plane wave exposures, EMC, 17:29-32, 2006.

0470B006(A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki: Temperature elevation in rabbit eye irradiatedby 2.45-GHz exposure systems, IEICE, 50:29-34, 2006.

0470B007(Y.Fukushima), H.Kato, H.Hayakawa, N.Komae, Y.Karasawa, M.Fukuda: Ocular pharmacokinetics of tosufloxacin
tosilate 0.3% ophthalmic solution, a novel fluoroquinolone antibiotic ophthalmic drug in rabbits, Journal of the eye.,
23:26-32, 2006 (in Japanese) .

0470B009

M.Fukuda, H.Sasaki, Y.Ohashi: Intraocular penetration of moxifloxacin ophthlamic solution in rabbit eyes calculaation of maximum drug concentration in aqueous-, Journal of the eye., 23:1353-1357, 2006 (in Japanese) .

0470B010(S.Sunada), A.Ueda, Y.Inoue, Y.Ohashi, T.Uno, K.Kitagawa, H.Hatano, H.Shiroda, S.Asari: Comparison ofminimum inhibitory concentration and postantibiotic effect of eyedrops on isolates in national surveillance of
infectious keratitis in japan, J Jpn Ophthalomol Soc., 110:973-983, 2006 (in Japanese) .

0470B011(Study Group of National Surveillance of Infectious Keratitis in Japan), K.Kitagawa: National surveillance of
infectious keratitis in japan -current status of isolates, patient background, and treatment-, J Jpn Ophthalomol
Soc., 110:961-972, 2006 (in Japanese) .

Case Reports
0470D001

T.Akai, K.Yamamoto, H.Iizuka, S.Kawakami, J.Yoshida, H.Kakimuma, H.Yaguchi, T.Ozawa: Syndromic
craniosynostosis with elbow joint contracture, Pediatr Neurosurg, 42:108-112, 2006.

Presentations at Conference
International Conference (Presentations)
0470I001

K.Kitagawa, K.Hagihara, M.Fukuda, H.Sasaki, K.Shimoyama, K.Fujimoto, N.Ogawa, S.Sugai: Can lissamine green
replace rose bengal as the golden standard for Sjogren's syndrome diagnosis, IX International Symposium on
Sjogren's Syndrome, (Washington DC, '06.04).

0470I002

H.Sasaki, K.Nagai, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson, K.Sasaki: Cataract in diabetes ; The Reykjavik
Eye Study, The Association for Research in Vision and Ophthalmolpgy, (Florida, '06.05).

0470I003

H.Yaguchi, Y.Sakamoto, J.Qu, K.Nagai, M.Kojima, H.Sasaki, K.Sasaki: Localization of fiber folds in the crystalline
lens and influence on visual function, The Association for Research in Vision and Ophthalmology, (Florida, '06.05).

－ 78 －

0470I004

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The Association
for Research in Vision and Ophthalmology, (Florida, '06.05).

0470I005

K.Sasaki, H.Sasaki, K.Nagai, H.Yaguchi, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson: Five-Year's lightscattering changes inlens layers in diabetics - The Reykjavik Eye Study -, The Association for Research in Vision
and Ophthalmology, (Florida, '06.05).

0470I006

M.Kojima, Y.Yamashiro, H.Sasaki, J.Qu, M.Hanazawa, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, K.Sasaki:
Investigation of safety exposure range by 60 GHz millimeter-wave for rabbit eyes, The Association for Research in
Vision and Ophthalmology, (Florida, '06.05).

0470I007

Y.Yamashiro, J.Qu, J.Tao, Y.Kawakami, M.Kojima, R.Honda, H.Sasaki, K.Sasaki: Characteristics of cataract ineyes with long axial length in a Chinese population, The Association for Research in Vision and Ophthalmology,(Florida, '06.05).

0470I008

H.Sasaki: Epidemiology Classification and diagnostic technique of cataract, The 6th Asian Cataract Research
Conference - Clinical Wokshop -, (Beijing, '06.06).

0470I009

Y.Sakamoto: New teqnique for examine visual function in cataract and pseudophakic eyes (Wavefront and PSF
sensor), The 6th Asian Cataract Research Conference - Clinical Workshop -, (Beijing, '06.06).

0470I010

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The 6th Asian
Cataract Research Conference, (Beijing, '06.06).

0470I011(J.Tao), J.Qu, R.Honda, M.Kojima, Q.Yan, J.Zhang, H.Sasaki, K.Sasaki: Prevalence of three main and six subtype
lens opacities in a rural Chinese population, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0470I012

K.Nagai, H.Sasaki, Y.Sakamoto, M.Kojima, K.Sasaki, F.Jonasson, R.Honda: Characteristics of lens opacity indiabetic patients - Reykjavik Eye Study -, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0470I013

M.Kojima, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, M.Hanazawa, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki:
Visualization of convective heat transportation of aqueous humor, The 6th Asian Cataract Research Congerence,(Beijing, '06.06).

0470I014(X.An), H.Sasaki, Y.Sakamoto, M.Kojima, Y.Kawakami, J.Tao, J.Qu, Z.Liu, J.Zhang, K.Sasaki: True exfoliation inchinese populationin a tropical area - The Senya Eye Study -, The 6th Asian Cataract Research Conference,(Beijing, '06.06).

0470I015

Y.Sakamoto, H.Nakaizumi, H.Sasaki, K.Sasaki: Higher order wavefront aberations with silicone asphric and acrylic
spherical intraocular lenses, The 6th Asian Cataract Research Conference, (Bijing, '06.06).

0470I016

M.Kojima, Y.Susuki, Y.Yamashiro, M.Hanazawa, A.Hirata, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki: Assessment of
the thermal insult on aqueous humor convtion utilizing micro - capsulated thermo - chromic liquid crystal, The
Bioelectromagnetis Society the 28th Annual Meeting, (Cancun, '06.06).

0470I017

H.Nakaizumi: Glaucoma following pediatric catarac surgery with without intraocular lens implantation, XXIV
European Society of Cataract and Refractive Surgeons, (London, '06.09).

0470I018

M.Fukuda, K.Kitagawa, K.Yamamoto, H.Sasaki: Cytotoxic effect of rose bengal and iissamine green on cultrured
rabbit corneal cell line, 10th International Society of Ocular Toxicology, (Bonn, '06.09).

0470I019

M.Kojima, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, M.Hanazawa, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki:
Relationship between crystalline lens injury by millimeter wave exposure and aqueous humor convection, 10th
International Society of Ocular Toxicology, (Bonn, '06.09).

0470I020

M.Kojima, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, M.Hanazawa, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki:
Investigation of convective heat transportation of aqueous humor during 60 GHz millimeter wave exposure, 4thInternational Workshop Biological Effects of Emfs, (Crete, '06.10).

0470I021

M.Kojima, Y.Suzuki, Y.Yamashiro, M.Hanazawa, S.Watanabe, M.Taki, Y.Sakamoto, H.Sasaki, K.Sasaki:
Relationship between the thermal insult by electromagneric wave exposure and convective heat transportation of
aqueous humor, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves, (Uchinada, '06.11).
－ 79 －

0470I022

Y.Sakamoto, H.Sasaki, M.Kojima, M.Ono, K.Sasaki: Sun altitude and effective protection items against UV
exposure to the ocular surface - UV dosimetry by mannequin head, 2006 KMU Workshop on Ocular Changes
Induced by Electromagnetic Waves, (Uchinada, '06.11).

0470I023(Y.Suzuki), M.Kojima, Y.Yamashiro, K.Wake, M.Taki, M.Hanazawa, S.Watanabe: In-situ 3D temperature imaging
with micro - encapsulated thermo - chromic liquid crystal for electromagenetic field dosimetry, 2006 KMU
Workshop on Ocular Changes Induced by Electromagneric Waves, (Uchinada, '06.11).

0470I024

Y.Yamashiro, M.Kojima, Y.Sakamoto, H.Kawada, H.Sasaki, K.Sasaki: Suitable methodology to detection ocular
injury for millimater wave exposure, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves,(Uchinada, '06.11).

0470I025

H.Sasaki, R.Honda, M.Kojima, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: High prevalence of pterygium in the
population of tropical area in China, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves,(Uchinada, '06.11).

0470I026(H.Wakatsuchi), M.Hanazawa, T.Sakai, S.Watanabe, M.Kojima, Y.Yamashiro, K.Sasaki, O.Hashimoto: Complex
permittivities measurements of eye tissues in quasi - millimeter wave band, 2006 KMU Workshop on Ocular
Changes Induced by Electromagnetic Waves, (Uchinada, '06.11).

－ 80 －

0480

Department of Otolaryngology

Faculty
Title

Name

Field of Specialization

Professor

TOMODA Koichi

Associate Professor

SUZUKA Yuko

Associate Professor

TSUJI Hiroyuki

Senior Assistant Professor

MURATA Hideyuki

Senior Assistant Professor

TAKASHIMA
Masayuki

Rhinology, Head and neck surgery, Endoscopic surgery, Computer
aided surgery
Head and neck surgery, Stomatopharyngology, Sleep study, Laser
medicine

Senior Assistant Professor

HORIGUTI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

Research Associate

ISHIMASA Hiroshi

Head and neck surgery, rhinology, General otolaryngology

Research Associate

IWASAKI Noriko

Head and neck oncology, Immune-allergic disease, generalotolaryngology

Research Associate

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Research Associate

NAKAIZUMI Toshihiko Otology, Clinical andbasic otology research

Research Associate

MIYAZAWA Toru

Basic otology research, Head and neck surgery

Research Associate

KITAMURA Miwa

Otolaryngology

Research Associate

SAKAI Aya

Sleep apnea, Otolaryngology

Research Associate

YAMADA Kanako

Audiology, Otolaryngology

Otology, Computer aided surgery, Head and Neck surgery,
Neuroimmunology
Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education
Head and neck oncology, Head and neck surgery

Keywords of Researchneurotology, otoneuro surgery, tympanoplasty, vestibular neurectomy, cochlear implant, middle ear implant, virtual
endoscopy, computer-aided surgery, endoscopic nasal surgery, laser surgery, sleep apnea & snoar surgery, skull base
surgery, head and neck tumor surgery, molecular biology, neuroimmunology, oncology, laryngology, speech rehabilitation,
acoustic neuroma surgery, navigation surgery, tele-medicine, thyroid tumor surgery, virtual education for surgery

Outline of Research
Research for 3D mobile navigation system
Central mechanism of auduological function by MEG
Restration for phonation with Provox 2 prosthesis
Clinical reserach for snoar and sleep apnea
Research for Thyroid and parathyroid gland
Inner ear molecular biology
Clinical survey for Head and Neck tumor and Oncology

Publications
Originals
0480B001

Z.Lan, A.Itoi, M.Takashima, M.Oda, K.Tomoda: Difference of pharyngeal morphology and mechanical property
between OSAHS patients and normal subjects, Auris Nasus Larynx, 33：433-439, 2006.
－ 81 －

0480B003

A.Itoi, M.Oda, M.Takashima: Clinical study of pathophysiology and severity in pediatric sleep related breathing
disorder, J. Kanazawa. Med. Univ., 31：1-9, 2006 (in Japanese) .

0480B004

M.Takashima, M.Oda, A.Itoi, K.Tomoda: Evaluation of surgical skill of uvulopalato pharyngo plasty (UPPP),
Stomato-pharyngology / Japan Society of Stomato-pharyngology., 18：393-400, 2006 (in Japanese) .

0480B005

H.Tsuji, M.Yagi, M.Minamino, M.Nagata, H.Yukawa, T.Minami, Y.Shimode, T.Yamashita: Clinical study ofparapharyngeal space tumors, Pract. otol., 99：481-490, 2006 (in Japanese) .

0480B006

H.Ishimasa, H.Murata: Investigation of objective evaluation system of anatomical knowledge and operativetechniques in education for rhinologic surgery, J. Kanazawa. Med. Univ., 31:62-72, 2006 (in Japanese) .

0480B007

H.Tsuji, M.Nagata, T.Inoue, T.Minami, H.Iwai, S.Ohnishi, H.Yukawa, M.Ogura, T.Yamashita, K.Nagata: Clinicalphase I trial of concurrent chemo-radiotherapy with S-1 for T2NO glottic carcinoma, Cancer & chemotherapy ;Japanese journal of cancer and chemotherapy., 33(Suppl.1)：163-166, 2006 (in Japanese) .

0480B008(M.Hasuo), M.Minamino, M.Yagi, H.Iwai, H.Tsuji, M.Konishi, T.Shimano, N.Sakaida, T.Yamashita: HER-2
expression in salivary duct carcinoma and trastuzumab therapy, Head and neck cancer., 32：68-71, 2006 (inJapanese) .

0480B009(M.Nagata), H.Tsuji, M.Minamino, T.Inoue, N.Yukawa, T.Fujisawa, M.Yagi, MOgura, M.Miyamoto, S.Chikano,
H.Iwai, T.Yamashita: A new incision for maxillary cancer-extented lateral rhinotomy+hemicoronal flap-, Head andneck cancer., 32：423-428, 2006 (in Japanese) .

0480B010(T.Inoue), H.Tsuji, T.Minami, M.Nagata, H.Yukawa, M.Minamino, M.Ogura, M.Yagai, T.Fujisawa, M.Miyamaoto,
S.Chikano, T.Yamashita: Long-term results of postoperative function after reconstruction of lateral and superior
oropharyngeal defects, Head and neck cancer., 32：474-480, 2006 (in Japanese) .

Case Reports
0480D001

K.Yamada, H.Murata, Y.Shimode, Y.Suzuka, K.Tomoda: The cases of gas gangrene of neck with dysphagia, Journalof Japan Society for Infectious Diseases in Otolaryngology., 24：165-169, 2006 (in Japanese) .

Others0480F005

H.Ishimasa, H.Murata, K.Tomoda, J.Yamashita: Investigation of objective evaluation system of anatomical
knowledge and operative techniques in education for rhinologic surgery, Oto-rhino-laryngology Tokyo., 49：283289, 2006 (in Japanese) .

0480F006

H.Murata, K.Tomoda: The measurement of error range between location of endoscopic field and CT images, Otorhino-laryngology Tokyo., 49:275-277, 2006 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0480H001

Y.Suzuka, K.Yamada, M. Higuchi, N. Hatsusaka, K.Tomoda: Variations of N100m responses in auditory evokedmagnetic field, KIT International Symposium on Brain and Language, (Tokyo, '06.03)，KIT international symposiumon brain and language, 17-18, 2006.

0480H002

K.Tomoda, H.Murata, H.Ishimasa, K.Yamada, Y.Suzuka: Image-guided navigation surgery in otorhinolaryngology,
The 23rd Congress of Pan-Pacific Surgical Association Japan Chapter, (Bangkok, '06.10).

0480H003

Y.Suzuka, T.Nakaizumi, K.Yamada, K.Tomoda: Experience of autologous fat injection to the vocal fold for glottic
insuficiency, The 23rd Congress of Pan-Pacific Surgical Association Japan Chapter, (Bangkok, '06.10).

0480H004

K.Tomoda, H.Murata, H.Ishimasa, Y.Ning: Current state of image-guided navigation surgery inotorhinolaryngology, 2006 Joint Meeting of Eight Departments of Otolaryngology, (Taipei, '06.11).

－ 82 －

International Conference (Presentations)
0480I001(M. Izumikawa), S. Batts, D.L. Swiderski, M.Crumling, T. Miyazawa, D. Dolan, Y.Raphael: The Severity of
Ototoxic Insult Affects Outcome of Atoh1 Treatment, Association for Research inOtolaryngology The 29th Annual
Midwinter Meeting, (Baltimore, '06.02).

0480I002

T. Miyazawa, M. Izumikawa, D.L. Swiderski, L.A. Beyer, M. Crumling, Y. Raphael: Viral Vector Inoculation into
the Apical Cochlear Endolymph Transduces cells throughout the Auditory Membranous Labyrinth, Association for
Research inOtolaryngology The 29th Annual Midwinter Meeting, (Baltimore, '06.02).

0480I003

K.Tomoda, H.Murata, H.Ishimasa, J.Yamashita: The evaluation of navigation surgery in nose and paranasal
sinuses, Computer assisted radiology and surgery 20th international congress and ehibition, (Osaka, '06.06)，
International Journal of computer assisted radiology and surgery, 1：311-323, 2006.

0480I004

Y.Suzuka, Y.Shimode, A.Horiguchi, K.Tomoda: Audiological Findings of Recent Acute Otitis Media, International
Otopathology Meeting, (Boston, '06.06)，International Otopathology Meeting, 21-22, 2006.

0480I005

Y.Suzuka, K.Yamada, M. Higuchi, N. Hatsusaka, K.Tomoda: The Study on Auditory Area Function of Right andLeft Hemisphere in Human, 15th International Conference on Biomagnetism, (Vancouver, '06.08)，15th
International Conference on Biomagnetism, 15：117, 2006.

0480I006

K.Yamada, H.Murata, Y.Shimode, Y.Suzuka, K.Tomoda: The cases of neck gas gangrene with dysphagia, The 23rd
Congress of Pan-Pacific Surgical Association Japan Chapter, (Bangkok, '06.10).

－ 83 －

0490

Department of Dermatology

Faculty
Title

Name

Professor

MOCHIZUKI Takashi Medical mycology ， Dermatomycosis

Associate Professor

TANABE Hiroshi

Medical mycology, Decubitns

Senior Assistant Professor

WATANABE Seiji

Medical mycology

Senior Assistant Professor

KAWASAKI Masako

Medical mycology

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Research Associate

TAKEDA Kiminobu

Medical mycology

Research Associate
Research Associate

TACHIKAWA
Nobuyuki
WAKAMATSU
Nobuhiko

Field of Specialization

Medical mycology
Dermatopathology

Research Associate

FUJITA Jun

Medical mycology

Research Associate

HASEI Maki

Skin tumor and growth factores，Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartyping, electron microscopy, dermatopathology, skin tumor

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

－ 84 －

Publications
Originals
0490B001(T. Uenotsuchi), S. Takeuchi, T. Matsuda, K. Urabe, T. Koga, H. Uchi, T. Nakahara, S. Fukagawa, M.Kawasaki,
H.Kajiwara, S.Yoshida, Y.Moroi, M.Furue: Differential induction of Th1-prone immunity by human dendritic cells
activated with Sporothrix schenckii of cutaneous and visceral origins to determine their different virulence, Int.
Immunol., 18：1637-1646, 2006.

0490B002(CJ.Jackson), T. Mochizuki, RC.Barton: PCR fingerprinting of Trichophyton mentagrophytes var. interdigitaleusing polymorphic subrepeat loci in the rDNA nontranscribed spacer, J. Med. Microbiol., 55：1349-1355, 2006.

0490B003(N.Umemoto), M.Kakurai, H.Yokokura, S.Toda, M.Osawa, H.Abe, Y.Hiratsuka, E.Okada, R.Azuma, Y.Wada,
M.Hayashi, T.Mochizuki, T.Demitsu: Analysis of dermatophyte flora for 5 years at Jichi Medical University Omiya
Medical Center in Saitama and identification of atypical dermatophytes using molecular biological Technique(PCRRFLP analysis), Jichi Medical School journal., 29:155-161, 2006 (in Japanese) .

Reviews
0490C003

T.Mochizuki, H.Tanabe, A.Wakasa, M.Kawasaki, K.Anzawa, H.Ishizaki: Survey of Trichophyton tonsurans
infection in Japan－Molecular epidemiology and factors affecting adequate hairbrush sampling－, The JapaneseSociety for Medical Mycology., 47：57-61, 2006 (in Japanese) .

Case Reports
0490D001(K.Haruna), Y.Shiraki, M.Hiruma, S.Ikeda, M. Kawasaki: A case of lymphangitic sporotrichosis occurring on bothforearms with a published work review of cases of bilateral sporotrichosis in Japan, J. Dermatol., 33：364-367,
2006.

0490D002

S.Watanabe, H.Tanabe, T.Mochizuki, M.Yanagihara, H.Ishizaki: Two Cases of Toe Web Infection by Pseudomonas
Aeruginosa, Skin research., 5：53-56, 2006 (in Japanese) .

0490D003

M.Nakagawa, K.Takeda, M.Yanagihara, H.Ishizaki, T.Mochizuki, T.Iura, S.Kataoka: A case of viper bite that
occurred during pregnancy, Nishinihon j. dermatol., 68：40-42, 2006 (in Japanese) .

0490D004

M.Nakagawa, H.Tanabe, M. Yanagihara, H.Ishizaki, T.Mochizuki: A case of meningomyelocele diagnosed withmalum perforans pedis, Skin research., 5：22-26, 2006 (in Japanese) .

0490D010(M.Maeda), T.Mochizuki: A case of onychomycosis caused by Fusarium oxysporum infection, Nishinihon j.
dermatol., 68：652-655, 2006 (in Japanese) .

0490D011

H.Ogawa, S.Watanabe, S.Abe, H.Tanabe, T.Mochizuki: A case of external region basel cell carcinoma the study ofbasal cell carcinoma for past 15 years in our department, Skin research., 5：411-414, 2006 (in Japanese) .

0490D015

H.Tanabe, M.Terada, M.Hasei, H.Ogawa, K.Anzawa, M.Kawasaki, T.Mochizuki, N.Ishikura: Problems of hairbrush
test for monitoring of Trichophyton tonsurans infection, Skin research., 5：430-434, 2006 (in Japanese) .

Short Communications
0490E001(P.Campos-Macìas), R.Arenas, Me Vega-Memije, M. Kawasaki: Sporothrix schenckii Type 3D (mtDNA- RFLP）：
Report of an osteoarticular case, J. Dermatol., 33：295-299, 2006.

Presentations at Conference
International Conference (Presentations)
0490I001

M.Kawasaki: Genetic and phenotypic variations among F1 progenies of Arthroderma benhamiae, 16th Congress of
the International Society for Human and Animal Mycology, (Paris, '06.06).
－ 85 －

0490I002

M.Kawasaki, A.Wakasa, K.Anzawa, H.Tanabe, T.Mochizuki, H.Ishizaki, S.Kagawa, B.Hemashettar: Multi-locus
analysis of infra- and inter-species variations among Trichophyton species, 16th Congress of the International
Society for Human and Animal Mycology, (Paris, '06.06).

0490I003

S.Watanabe, K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Strain typing of Fonsecaea pedrosoi strains by
PCR-RFLP analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0490I004

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, J. Choi: Molecular epidemiology of Trichophyton
tonsurans isolation in Japan, 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0490I005

H.Ishizaki, M.Kawasaki, T.Mochizuki, A.Chakrabarti, R.Ungpakorn, J.Yamashita, C.Zaitz, H.Guerrero, C.Toriello,
R.Arenas: Mitochondrial DNA analysis of Sporothrix schenckii isolated from India, Thailand, Brazil, Guatemala,Colombia and Mexico., 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0490I006

K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Identification of species from scale from dermatophytosis lesions
by PCR-RFLP analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0490I007

K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Identification of dermatophytes in the nail by PCR-RFLP
analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0490I008

K.Anzawa, M.Kawasaki, H.Tanabe, T.Mochizuki, H.Ishizaki: Genotype analysis of Candida albicans isolated fromthe human oral cavity, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0490I009(Ｃ. Jackson), T.Mochizuki, R.Barton: Recent developments in the molecular subtyping of anthropophilicdermatophyte fungi, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06).

－ 86 －

0500

Department of Urogenital Surgery

Title

Name

Field of Specialization

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Associate Professor

TANAKA Tatsuro

kidney transplantation, endourology

Associate Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Senior Assistant Professor

KAWAMURA Kenjikidney stone disease, urogenital cancer

Senior Assistant Professor

MORIYAMA Manabu

kidney stone disease, kidney transplantation

Research Associate

SUGA Koudai

general urology

Research Associate

CHIKAZAWA Ippei

general urology

Research Associate

TOKUNAGA Kousuke general urology

Research Associate

TACHIBANA
Hiromichi

general urology

Research Associate

ISHII Takeo

general urology

Research Associate

MORITA Nobuyo

general urology

Faculty

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation,mechanism of urolithiasis

Publications
Originals
0500B001(K.Fujimoto), Y.Hirao, N.Masumori, Y.Arai, H.Yamanaka, T.Kato, K.Miyazawa: Prostate-specific antigen changes
as a result of chlormadinone acetate administration to patients with benign prostatic hyperplasia: A retrospective
multi-institutional study, Int. J. Urol., 13:543-549, 2006.

0500B002(PK.Grover), K.Miyazawa, M.Coleman, J.Stahl, RL.Ryall: Renal prothrombin mRNA is significantly decreased in a
hyperoxaluric rat model of nephrolithiasis, J. Pathol., 210:273-281, 2006.

0500B003

K.Kawamura, N.Morita, C.Domiki, K.Fujikawa-Yamamoto, M.Hashimoto, K.Iwabuchi, K.Suzuki: Induction ofcentrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure, Cancer Sci., 97:252258, 2006.

0500B004

K.Aihara, N.Morita, I.Chikazawa, M.Moriyama, K.Kawamura, K.Miyazawa, T.Tanaka, C.Tanaka, Y.Nakamoto,K.Suzuki: An investigation of blood culture positive cases in the department of urology, J. Kanazawa. Med. Univ.,
31:132-137, 2006 (in Japanese) .

－ 87 －

0500B005

K.Aihara, K.Kawamura, S.Matsuda, Y.Inoue, T.Yamano, J.Tabuchi, Y.Shimizu, N.Morita, I.Chikazawa,
M.Moriyama, K.Miyazawa, T.Tanaka, K.Suzuki: Induction of clinical pathways in portless endoscopic urologicalsurgery for prostate cancer, Journal for Japanese Society for Clinical Pathway, 8:125-132, 2006 (in Japanese) .

Case Reports
0500D001

H.Shikata, K.Miyazawa, Y.Ueda, T.Kobata, K.Hida, J.Matsubara: A case of synchronous renal cell carcinoma
producing granulocyte colony stimulating factor(G-CSF) and abdominal aortic aneurysm, Jpn. J. Cardiovasc.Surg.,
15:521-524, 2006.

0500D002

H.Shikata, K.Kurose, T.Kobata, K.Hida, M.Moriyama, N.Morita, S.Sakamoto, K.Suzuki, J.Matsubara: Surgicaltreatment of abdominal aortic aneurysm accompanied by bilateral large multicystic kidneys, The Japanese Society
for Cardiovascular Surgery., 35：251-254, 2006 (in Japanese) .

0500D003

T.Tanaka, M.Moriyama, T.Hayama, K.Suzuki: A case of ABO incompatible kidney transplantation complicated bypostoperative massive hemorrhage, Renaltransplantation･vascular surgery., 18:51-55, 2006 (in Japanese) .

Others
0500F001

K.Sato, H.Tachibana, T.Tsuzuki, Y.Ueda, S.Katsuda: Prostatic ductal adenocarcinoma mimicking villous adenomaof the urethra, Virchows Arch., 449:597-599, 2006.

－ 88 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

Professor

MAKINODA Satoru

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines

Associate Professor

IURA Toshihikoperinatal medicine, perinatal diagnosis

Senior Assistant Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Research Associate

FUJITA Satoko

perinatal medicine, reproductive medicine

Research Associate

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology

Research Associate

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis

Research Associate

INOUE Hirokazu

perinatal medicine, perinatal diagnosis

Research Doctor

KUWAHARA Takashi perinatal medicine

Research Doctor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 89 －

Publications
Originals
0510B001

T.Iura, S.Makinoda, C.Sasakura, N.Hirosaki, H.Inoue, T.Waseda, Y.Watanabe: Hemodynamic analysis of
cephalothoracopagus by the color doppler method, Fetal. Diagn. Ther., 21:61-64, 2006.

0510B002(P.Dahm-Kahler), C.Lofman, R.Fujii, M.Axelsson, P.O.Janson, M.Brannstrom: An intravital microscopy method
permitting continuous long-term observations of ovulation in vivo in the rabbit, Hum. Reprod., 21:624-631, 2006.

0510B003

C.Sasakura: The usefulness of MRI in the diagnosis of fetal lung maturity, J. Kanazawa. Med. Univ., 31:269-273,
2006 (in Japanese) .

0510B004

N.Hirosaki: Study on the feasibility of G-CSF as a supportive drug in ovulation induction for luteinized unruptured
follicle, J. Kanazawa. Med. Univ., 31:274-280, 2006 (in Japanese) .

Case Reports
0510D001

M.Nakagawa, K.Takeda, M.Yanagihara, H.Ishizaki, T.Mochizuki, T.Iura, S.Kataoka: A case of viper bite that
occurred during pregnancy, Nishinihon j. dermatol., 68：40-42, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0510I001

S.Makinoda, N.Hirosaki, K.Yanagi, R.Fujii, K.Yoshida: The involvement of granulocyte colony-stimulating
factor(G-CSF) in the human ovulatory process, 12th World Congress of Gynecological Endocrinology, (Florence,'06.03).

0510I002

N.Hirosaki, R.Fujii, L.Gang, K.Yanagi, K.Yoshida, S.Makinoda: Possible involvement of interleukin-6 in humanluteolysis, 12th World Congress of Gynecological Endocrinology, (Florence, '06.03).

0510I003

T.Iura, S.Makinoda, H.Inoue, S.Fujita, T.Waseda, C.Sasakura, Y.Watanabe: Prenatal diagnosis of fetal renal
disease using color doppler ultrasound, International Symposium Japanese-German Society of Obstetrics andGynecology, (Niigata, '06.04).

0510I004

R.Fujii, G.Lu, K.Yanagi, N.Hirosaki, K.Yoshida, S.Makinoda: Periodic changes of interleukin-6 (IL-6) and its
receptors mRNAs in the human ovary- Possible involvement of IL-6 in human luteolysis-, The International
Ovarian Conference 2006, (Yokohama, '06.05).

0510I005

R.Fujii, N.Hirosaki, K.Yanagi, T.Iura, S.Makinoda: The involvement of granulocyte colony-stimulating factor(GCSF) in the release of a mature oocyte., 6th Sapporo International Symposium on Ovarian Function, (Otaru,'06.08).

0510I006

T.Iura, S.Makinoda, H.Inoue, S.Fujita, T.Waseda, C.Sasakura, Y.Watanabe: Prenatal diagnosis of fetal renal
disease using color doppler ultrasound, 16th World Congress on Ultrasound in Obstetrics and Gynecology,(London, '06.09).

0510I007

H.Inoue, N.Neyatani, T.Waseda, S.Matsuzawa, T.Iura, S.Makinoda: Analysis of renal artery hemodynamics innormal fetuses using the color doppler method, 16th World Congress on Ultrasound in Obstetrics and Gynecology,(London, '06.09).

0510I008

T.Waseda, H.Inoue, T.Iura, S.Makinoda: An attempt to evaluate the placental function by using myometrial bloodflow analysis, 16th World Congress on Ultrasound in Obstetrics and Gynecology, (London, '06.09).

0510I009

H.Tomizawa, H.Inoue, K.Ohshima, T.Iura, S.Makinoda: Markers to predict the prognosis of pregnancy at 5 week ofgestation, 12th International Federation of Placenta Associations Meeting, (Kobe, '06.09).

0510I010

T.Waseda, C.Sasakura, H.Tomizawa, R.Fujii, K.Yoshida, T.Iura, S.Makinoda: At attempt to evaluate the placental
function by using myometrial blood flow analyse, XVIIIth FIGO, (Kuala Lumpur, '06.11).
－ 90 －

0510I011

C.Sasakura, S.Fujita, S.Matsuzawa, T.Waseda, Y.Watanabe, H.Tomizawa, M.Sakaihara, T.Iura, S.Makinoda: The
usefulness of MRI in the diagnosis of fetal pulmonary maturity, XVIIIth FIGO, (Kuala Lumpur, '06.11).

－ 91 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular Effects of Anesthetics, Intravenous Anesthetics

Associate Professor

SEKI Sumihiko

Vascular Reactivity and Cellular calcium dynamics

Senior Assistant Professor

SHIRAISHI Miharu

Cardiac Anesthesia, Cardiovascular Agents

Senior Assistant Professor

HIDAKA Koji

Cerebral ischemia

Research Associate

SHIMO Tomohiro

Anaphylaxis

Research Associate

FUKUOKA Tadashi

Intensive care

Research Associate

HORIUCHI Katsura

General anesthesia, Local anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, paraquat, sepsis, delayed neuronal death, apoptosis, inducible nitric oxide synthase, brainischemia, epidural blockade, cytochrome P-450, liver mitochondoria, nitric oxide, hypothermia

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined 1) the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole, and 2) the effects of transient forebrain ischemia on
apoptotic death of the hippocampal pyramidal neuron in Mongolian gerbil.

Publications
Originals
0520B001

T.Shibamoto, T.Ishibashi, T.Shimo, S.Cui, H.Takano, H.Tsuchida, M.Nishio, Y.Kurata: NG-nitro-L-arginine
methyl ester potentiates anaphylactic venoconstriction in rat perfused livers, Clin. Exp. Pharmacol. Physiol.,
33:1073-1077, 2006.

Short Communications
0520E001

T.Shimo, S.Nishiike, M.Shiraishi, S.Seki, H.Tsuchida: Intraoperative anaphylactic shock induced bymethylergometrine and oxytocin, The Japanese journal of anesthesiology., 55:447-450, 2006 (in Japanese) .

0520E002

H.Wada, K.Nakamura, S.Nishiike, S.Seki, H.Tsuchida: The combined use of laryngoscope and trachlight®: Anotheroption for endotracheal intubation in patients with large epiglottic cysts, The Japanese journal of anesthesiology.,
55：468-470, 2006 (in Japanese) .

－ 92 －

Presentations at Conference
International Conference (Presentations)
0520I001

S.Sugiura, K.Hidaka, S.Seki, H.Tsuchida: Hemodynamic effects of landiolol , an ultra-short acting β1－selective
blocker, on endotracheal intubation in hypertensive patients, IARS 80th Clinical & Scientific Congress, (SanFrancisco, '06.03).

0520I002

S.Nishiike, K.Hidaka, S.Seki, H.Tsuchida: Factor influencing an induction time with 2.5 MAC sevoflurane
inhalation, IARS 80th Clinical & Scientific Congress, (San Francisco, '06.03).

－ 93 －

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

YOSHMURA Hiroshi

temporomandibular joint disorders, stomatology, neuroscience

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery

Senior Assistant Professor

DEMURA Noboru

orthodontics, stomatology

Research Associate

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology

Research Associate

NAGAO Toshikazu

temporomandibular joint disorders, stomatology

Research Associate

NISHIURA Rie

temporomandibular joint disorders, stomatology

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0530B001

H.Yoshimura, M.Honjo, N.Segami, K.Kaneyama, T.Sugai, Y.Mashiyama, N.Onoda: Cyclic AMP-dependent
attenuation of oscillatory-activity-induced intercortical strengthening of horizontal pathways between insular andparietal cortices, Brain Res., 1069:86-95, 2006.

0530B002

K.Fujimura, N.Segami, S.Kobayashi: Anatomical study of the complications of intraoral vertico-sagittal ramus
osteotomy, J. Oral Maxillofac. Surg., 64:384-389, 2006.

0530B003

K.Fujimura, N.Segami, Y.Yoshitake, N.Tsuruoka, K.Kaneyama, J.Sato, S.Kobayashi: Electrophoretic separation of
the synovial fluid proteins in patients with temporomandibular joint disorders, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 101:463-468, 2006.

0530B004

M.Nishimura, N.Segami, K.Kaneyama, J.Sato: Systemic lymphangiomatosis of bone involving the mandible withcystic hygroma of the neck, J. Oral Maxillofac. Surg., 64:1157-1160, 2006.

0530B005

T.Sugai, H.Yoshimura, N.Kato, N.Onoda: Component-dependent urine responses in the rat accessory olfactorybulb, Neuroreport., 17:1663-1667, 2006.
－ 94 －

0530B006

M.Honjo: Influences of multiple tooth losses during developmental periods on the maturation of oral sensory
cortices of rats, J. Kanazawa. Med. Univ., 31:73-81, 2006 (in Japanese) .

0530B007

S.Kobayashi: Histological evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits,
J. Kanazawa. Med. Univ., 31:42-52, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0530I001

N.Segami: Eminectomy for habitual dislocation under local anesthesia ; An experience with 11cases, 18th Congressof the European Association for Cranio-Maxillofacial Surgery, (Barcelona, '06.07).

－ 95 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency,Emergency medical syctem,Disaster Medicine,

Senior Assistant Professor

MASHIBA Satoru

Emergency,Anaphylaxis

Research Associate

HAYASHI Nobuyuki

Emergency,

Research Associate

MORITA Hideki

Emergency,

Research Associate

GOTO Tetsuro

Emergency,

Research Associate

MIZUNUMA Mariko

Emergency,

Research Associate

NAKATA Mari

Emergency,

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

－ 96 －

0560

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical oncology, Gastroenterology, Pancreatology

Associate Professor

KIBA Takayoshi

Medical oncology, Gastroenterology

Senior Assistant Professor

NAKAJIMA Hideo

Medical oncology, Immunology

Research Associate

SHIMASAKI Takeo

Medical oncology, Gastroenterology, BioInformatics

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0560B001(J.Pei-Hong), Y.Motoo, N.Sawabu, T.Minamoto: Effect of gemcitabine on the expression of apoptosis-related genes
in human pancreatic cancer cells, World J. Gastroenterol., 12:1597-1602, 2006.

0560B002(J.Pei-Hong), Y.Motoo, S.Garcia, JL.Iovanna, MJ.Pebusque, N.Sawabu: Down-expression of tumor protein p53induced nuclear protein 1 in human gastric cancer, World J. Gastroenterol., 12: 691-696, 2006.

0560B003(Y.Ito), Y.Motoo, H.Yoshida, JL.Iovanna, Y.Nakamura, K.Kuma, A.Miyauchi: High level of tumour protein p53induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid, Pathology., 38:545-547,
2006.

Reviews
0560C009

Y.Motoo, K.Tsutani: Is it possible to develop global clinical practice guidelines for traditional medicine?, Japanesejournal of oriental medicine., 57: 465-475, 2006 (in Japanese) .

Case Reports
0560D001

J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda: Effectiveness of goshajinkigan on the cold sensationand dysthesia in a case of nodular multiple angiitis, Japanese journal of oriental medicine., 57：651-654, 2006 (inJapanese) .

－ 97 －

Presentations at Conference
International Conference (Synposium)
0560H001

Y.Motoo: How to develop an international clinical practice guideline for lung cancer, WHO Workshop on Guideline
Development for Cancer, (Budapest, Hungary, '06.10).

International Conference (Presentations)
0560I001

Y.Motoo: Down-expression of TP53INP1 in human gastric cancer., American Society of Clinical OncologySymposium on Gastrointestinal Cancers (ASCO-GI), (San Francisco, CA, USA, '06.01).

0560I002

Y.Motoo, T.Shimasaki: Molecular mechanisms of anti-tumor effect of gemciatbine hydrochloride on humanpancreatic cancer cells., The 28th World Congress of Internal Medicine, (Taipei, '06.11).

－ 98 －

0610

Health Management Center

Faculty
Title

Name

Professor

MATSUDA Yoshiro

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

YASUDA Yukio

evidence-based health care

Professor(Additional Post)

YAMADA Yuichi

Occupational health, Epidemiology for cardiovascular and pulmonary
diseases

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

MIURA Katsuyuki

Cardiovascular epidemiology, preventive cardiology, clinicalepidemiology

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine

Senior Assistant Professor

HAYASE Mitsuru

Senior Assistant Professor

KUGINUKI Yasuaki

hemodynamics

Research Associate

KUSAKA Kazuya

英文の研究領域を入力してください。

Research Associate

YABUNO Yoshinori

Diagnostic Imaging

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Field of Specialization

Keywords of Researchstress, eating habit, health examinaition, screening, exercise, nutrient intake, life style, obestity

Publications
Originals
0610B001(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant (C825T) is unlikely to have a significant influence on serum total cholesterol level
in Japanese workers, Clin. Exp. Hypertens., 28:47-56, 2006.

0610B002(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism
A1330V are risk factors for hypercholesterolemia in Japanese males –a prospective study over 5 years, Metab.
Clin. Exp., 55:751-757, 2006.

0610B003(Elliott.P), Stamler.J, Dyer.AR, Appel.L, Dennis.B, Kesteloot.H, H.Ueshima, A.Okayama, Chan.Q, Garside.DB,
Zhou.B, for the INTERMAP Cooperative Reserch Group, H.Nakagawa, K.Miura: Association between protein
intake and blood pressure: the INTERMAP study, Arch. Intern. Med., 166:79-87, 2006.

0610B004(M.Sakurai), K.Miura, T.Takamura, T.Ota, M.Ishizaki, Y.Morikawa, T.Kido, Y.Naruse, H.Nakagawa: Genderdifferences in the association between anthropometric indices of obesity and blood pressure in Japanese,
Hypertens. Res., 29:75-80, 2006.

－ 99 －

0610B005(S.Omote), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono, E.Kobayashi, N.Nogawa: Urinary type I collagen crosslinked N-telopeptides in inhabitants 18Years after cessation of exposure to cadmium in Japan, Bull. Environ.
Contam. Toxicol., 76:187-94, 2006.

0610B006

H.Nakagawa, M.Nishijo, Y.Morikawa, K.Miura, K.Tawara, J.Kuriwaki, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa:
Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan, Environ Res, 100:323-329,
2006.

0610B007

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0610B008(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant A1330V is a determinant of blood pressure in Japanesemales, Life Sci., 78:2475-2479, 2006.

0610B009

F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda:
Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, J.
Int. Med. Res., 34:297-302, 2006.

0610B010(M.Uetani), E.Kobayashi, Y.Suwazono, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Smoking does not influencecadmium concentrations in blood and urine in relatively high levels of environmental cadmiun areas in Japan, Biol
Trace Elem Res, 110:107-118, 2006.

0610B011(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit gene variant is unlikely to have a significant influence on serum uric acid level in Japanese
workers, Tohoku J. Exp. Med., 209:149-157, 2006.

0610B012

K.Miura, H.Nakagawa, H.Ueshima, A.Okayama, S.Saitoh, JD.Curb, BL.Rodriguez, K.Sakata, N.Okuda, K.Yoshita,
J.Stamler, INTERMAP and INTERLIPID Research Groups: Dietary factors related to higher plasma fibrinogenlevels of Japanese-americans in hawaii compared with Japanerse in Japan, Arterioscler. Thromb. Vasc. Biol.,
26:1674-1679, 2006.

0610B013(K.Wada), T.Satoh, M.Tsunoda, Y.Aizawa, and the Japan Work Stress and Health Cohort Study Group, M.Ishizaki:
Associations of health behaviors on depressive symptoms among employed men in Japan, Ind Health, 44:486-492,
2006.

0610B014

S.Matsui, L.Larsson, M.Hayase, S.Katsuda, K.Teraoka, T.Kurihara, H.Murano, K.Nisikawa, M.Fu: Specificremoval of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy
improved cardiac structure and function, J. Mol. Cell. Cardiol., 41:78-85, 2006.

0610B015

M.Nishijo, Y.Morikawa, H.Nakagawa, K.Tawara, K.Miura, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Causes ofdeath and renal tubular dysfunction in residents exposed to cadmium in the environment, Occup Environ Med,
63:545-550, 2006.

0610B016(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose for renal dysfunction in a cadmium non-polluted area in Japan, J. Appl. Toxicol., 26:351-355,
2006.

0610B017(M.Uetani), E.Kobayashi, Y.Suwazaono, R.Honda, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Tissue cadmium(Cd) concentrations of people living in a Cd polluted area, Japan, Biometals, 19:521-525, 2006.

0610B018(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Gprotein β3 subunit variant C825T is a risk factor for hypertension in Japanese females -a prospective cohort
study over 5 years, Ann. Hum. Genet., 70:767-777, 2006.

0610B019

M.Ishizaki, N.Kawakami, R.Honda, H.Nakagawa, Y.Morikawa, Y.Yamada, The Japan Work Stress and HealthCohort Study Group: Psychosocial work characteristics and sickness absence in Japanese employees, Int. Arch.
Occup. Environ. Health., 79:640-646, 2006.

0610B020(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: Lowdensity lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females,
Blood Press., 15:80-87, 2006.
－ 100 －

0610B021(E.Kobayashi), Y.Suwazono, M.Uetani, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Tolerable level of lifetime
cadmium intake estimated as a benchmark dose low, based on excretion of β2-microglobulin in the cadmiumpolluted regions of the Kakehashi River Basin, Japan, Bull. Environ. Contam. Toxicol., 76:8-15, 2006.

0610B022(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, β２-microglobulin,
and N-acetyl-β-D-glucosaminidase in cadmium nonpolluted regions in Japan, Environ Res, 101:401-406, 2006.

0610B023(Y.Suwazono), E.Kobayashi, M.Uetani, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, H.Nakagawa, K.Nogawa: The 1438A/G polymorphism in the 5-hydroxytryptamine receptor 2A gene is related to hyperuricemia, increased γglutamyl transpeptidase and decreased high-density lipoprotein cholesterol level in the Japanese population: aprospective cohort study over 5 years, Int. J. Mol. Med., 17:77-82, 2006.

0610B024

Y.Yamada, T.Imai, M.Ishizaki, R.Honda: ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and thehealth consequences in moderate alcohol consumers, J. Hum. Genet., 51:104-111, 2006.

0610B025(T.Miyamoto), E.Kobayashi, Y.Suwazono, M.Uetani, M.Nishijo, K.Miura, H.Nakagawa, K.Nogawa: Changes inurinary excretions of cadmium, copper, and zinc in Japanese workers., Arch. Environ. Occup. Health., 61:251222, 2006.

0610B026

M.Nakashima, K.Miura, T.Sakai, M.Bansho, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Attiude to smoking
and effect of anti-smoking education in elementary school 6th grade students, Hokuriku Japanese Journal of Public
Health., 32:73-78, 2006 (in Japanese) .

0610B027

K.Miura, H.Myogadani, Y.Kadoya, M.Hayashi, M.Motoya, M.Kuzumaki, M.Yoneda, T.Mitsui, M.Nishijo,
Y.Morikawa, Y.Nakanishi, M.Nakashima, H.Nakagawa: Effectiveness of lifestyle modification programs for control ofblood pressure: A non-randomized controlled trial in Komatsu, Japan, Japanese Journal of Public Health., 53:533542, 2006 (in Japanese) .

Reviews
0610C001

F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda:
Traditional chinese medicine and kampo: a review from the distant past for the future, J. Int. Med. Res., 34:231239, 2006.

0610C002(S.Satarug), M.Nishijo, JM.Lasker, RJ.Edwards, MR.Moore: Kidney dysfunction and hypertension:role forcadmium,P450 and heme oxygenases?, Tohoku J. Exp. Med., 208:179-202, 2006.

Case Reports
0610D001

K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda:
Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, J. Int. Med. Res., 34:437440, 2006.

0610D002

J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda: Effectiveness of goshajinkigan on the cold sensationand dysthesia in a case of nodular multiple angiitis, Japanese journal of oriental medicine., 57：651-654, 2006 (inJapanese) .

Presentations at Conference
International Conference (Presentations)
0610I001

K.Miura, H.Nakagawa, H.Ueshima, A.Okayama, S.Saitoh, JD.Curb, B.Rodriguez, K.Sakata, N.Okuda, K.Yoshita,
J.Stamler: Dietary factors related to the plasma fibrinogen difference between Japanese in Japan and JapaneseAmericans in Hawaii: the INTERLIPID Study, 46th Annual Conference on Cardiovascular Disease Epidemiology
and Prevention, American Heart Association, (Phoenix, '06.03).

－ 101 －

0610I002(K.Yoshita), K.Miura, N.Okuda, A.Okayama, S.Saitoh, H.Nakagawa, K.Sakata, S.Archer, P.Elliott, J.Stamler,
H.Ueshima, for the INTERMAP Research Group: Effects of dietary supplement use on average total micronutrient
intake in middle-aged Japanese: the INTERMAP Study, 46th Annual Conference on Cardiovascular Disease
Epidemiology and Prevention, American Heart Association, (Phoenix, '06.03).

0610I003

S.Yoneyama, K.Miura, S.Sasaki, S.Yoshita, M.Morikawa, Y.Soyama, M.Ishizaki, T.Kido, Y.Naruse, H.Nakagawa:
Relationship of dietary intake of fatty acids to serum C-reactive protein in Japanese, 14th International Symposium
on Atherosclerosis, (Rome, '06.06)，Atherosclerosis, 7:290, 2006.

0610I004

M.Nishijo, H.Nakagawa, R.Honda: A trial for a global standard health management for Cd pollution, Health risk
management for environment and labour, (Tokyo, '06.06)，URMPM special conference, 52, 2006.

0610I005

M.Ishizaki, Y.Morikawa, H.Nakagawa, R.Honda, N.Kawakami, T.Haratani, F.Kobayashi, S.Arai: Relationshipbetween change of job demand/control and absence from work, 28th International Congress on Occupational
Health, (Milan, '06.06)，Book of Abstracts, 292, 2006.

0610I006(N.Kawakami), T.Haratani, F.Kobayashi, M.Ishizaki, T.Hayashi, O.Fujita, Y.Aizawa, S.Miyazaki, H.Hiro,
T.Masumoto, S.Hashimoto, S.Araki: Job Insecurity and increased risk of stroke in Japanese men: a prospective
finding from the jstress study, 28th International Congress on Occupational Health, (Milan, '06.06)，Book of
Abstracts, 41, 2006.

0610I007

M.Nishijo, H.Nakagawa, R.Naganuma, K.Tawara, T.Kido, H.Suzuki: An epidemiological study on health effects bydioxin in vietnam;conparison of contrast acuity between inhabitants of herbicide sprayed and non-sprayed areas,
26th International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0610I008

M.Nishijo, H.Nakagawa, Y.Morikawa, K.Tawara, J.Kuriwaki, E.Hori, H.Nishijo: Effect of 2,3,7,8thtrachlorodibenzo-p-dioxin exposure during pregnancy on the neurodevelopment of rat off-springs, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0610I009

M.Nishijo, H.Nakagawa, K.Tawara, T.Kido, R.Naganuma: Areal differences of concentration levels ofpolychlorinated debenzo-p-dioxins and dibenzofurans in human breast milk from Vietnam and Japan, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0610I010

K.Miura, H.Nakagawa, T.Kushiro, A.Takahashi, M.Nishinaga, H.Soejima, M.Taguri, R.Matsukawa, A.Harada,
Y.Ohashi, H.Ueshima, for the JALS Group.: Comparison of four blood pressure indexes in predicting stroke andmyocardial infarction: a meta-analysis of 15 cohort studies in Japan, 21th Scientific Meeting of the International
Society of Hypertension, (Fukuoka, '06.10)，J Hypertens, 24(suppl 6):S84, 2006.

0610I011(Q.Chan), J.Stamler, K.Miura, B.Zhou, P.Elliott: Relation of type, pattern of alcohol intake to blood pressure: the
INTERMAP Study, 21th Scientific Meeting of the International Society of Hypertension, (Fukuoka, '06.10)，J
Hypertens, 24(suppl 6):S57, 2006.

－ 102 －

0620

Department of Pathology

Faculty
Title
Research
Associate(Additional Post)
Research
Associate(Additional Post)

Name

Field of Specialization

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Publications
Case Reports
0620D001

K.Sato, M.Takenaka, M.Nakano, T.Terauchi, Y.Ueda, S.Katsuda: A case of mixed mucinous and nonmucinous typebronchioloalveolar carcinoma, J. Jpn. Soc. Clin. Cytol., 45:103-105, 2006 (in Japanese) .

－ 103 －

0630

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase,Diabetes Mellitus,Mental distase

Associate Professor

ITOU Tohru

Diaqnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer, earygastric cancer, eary colon cancer

Associate Professor

TAKAHASHI Takashi Infections disease,Respiratory medicine,Clinical microbiology

Research
Associate(Additional Post)

KUSAKA Kazuya

Diaqnosis for esophagus,gastro-intestine,colon,liver & bileductdisease.Endoscopical treatment of its disease,especially,superficial
type esophageal cancer, earygastric cancer, eary colon cancer

Research Associate

YAMAKAWA Junichi

Nenurology,Kampo medicine

Keywords of Researchcardiology, gastroenterology, neurology, clinical epidemiology, alternative, clinical ethics, hospital management, diagnostic& treatment endoscopy, general practise, obesity, cytokine, gastric cancer, infection

Outline of Research
Three major investigations are proceeded. One is to investigate thetherapeutic implication of cytokine against viral myocarditis, chronic
fatigue syndrome, infection due to obese through immunomodulation. The
second is to investigate the new methods of endoscopic therapy against
gastric cancer and colon tumors. The third is to apply the kampo
medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

T.Takahashi, Y.Fei, Z.Shi-jie, J.Moriya, H.Sumino, S.Morimoto, N.Yamaguchi, T.Kanda: Beneficial effect ofbrewers' yeast extract on daily activity in a murine model o f chronic fatigue syndrome, eCAM, 3:109-115, 2006.

0630B002

T.Takahashi, F.Yu, S.Saegusa, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, M.Kurabayashi, T.Kanda: Impaired
expression of cardiac adiponectin in leptin-deficient mice with viral myocarditis, Int. Heart J., 47:107-123, 2006.

0630B003(H.Sumino), S.Ichikawa, T.Takahashi, H.Sakamoto, K.Goto-Onozato, S.Koya, T.Kanda, M.Nara, K.Seki,
M.Murakami, M.Kurabayashi: Conjugated estrogen plus medroxyprogesterone does not impair blood rheologicalproperties in hypertensive postmenopausal women, Maturitas, 53:306-314, 2006.

0630B004(H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, T.Sakamaki, M.Kurabayashi:
Elevated arterial stiffness in postmenopausal women with osteoporosis, Maturitas, 55:212-218, 2006.

0630B005(H.Sumino), S.Ichikawa, S.Kasama, T.Takahashi, H.Kumakura, Y.Takayama, T.Kanda, M.Kurabayashi: Different
effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers
in postmenopausal women, Atherosclerosis, 189:436-442, 2006.

0630B006

F.Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, H.Sumino, S.Morimoto, T.Kanda:
Angiotensin-Ⅱ receptor antagonist alleviates non-alcoholic fatty liver in kkay obese mice with type2 diabetes, J.
Int. Med. Res., 34:297-302, 2006.

－ 104 －

0630B007(T.Yuuki), T.Kanda, S.Kishi: Expression of ephrin in retinal neovascularization and iris rubeosis, J. Int. Med. Res.,
34:485-494, 2006.

0630B008

M.Okuro, S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, H.Murai, K.Iwai, T.Kanda: Angiotensin Ⅰconverting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans,
Hypertens. Res., 29:655-663, 2006.

0630B009

S.Morimoto, T.Takahashi, K.Okaishi, T.Nakahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino,
M.Matsumoto: Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly
inpatients:effects of azelnidipine, Hypertens. Res., 29:943-949, 2006.

0630B010

J.Moriya: Establishment of murine model for chronic fatigue syndrome and efficacy of Kampo Medicine on daily
activity, J. Kanazawa. Med. Univ., 31:263-268, 2006 (in Japanese) .

0630B011

S.Saegusa: Myocardial protective action of the angiotensin Ⅱ type 1 receptor blocker (ARB) in the acute viral
myocarditis of mice with metabolic syndrome -Meaning of adiponectin expression by cardiac muscle-, J. Kanazawa.
Med. Univ., 31:209-215, 2006 (in Japanese) .

Reviews
0630C001

F Yu, T.Takahashi, J.Moriya, K.Kawaura, J.Yamakawa, K.Kusaka, T.Itoh, S.Morimoto, N.Yamaguchi, T.Kanda:
Traditional chinese medicine and kampo: a review from the distant past for the future, J. Int. Med. Res., 34:231239, 2006.

Case Reports
0630D001

K.Kusaka, T.Itoh, K.Kawaura, J.Moriya, J.Yamakawa, T.Takahashi, M.Oguchi, H.Tonami, I.Yamamoto, T.Kanda:
Advanced oesophageal carcinoma in an 84- year-old treated with chemoradiotherapy, J. Int. Med. Res., 34:437440, 2006.

0630D002

J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda: Effectiveness of goshajinkigan on the cold sensationand dysthesia in a case of nodular multiple angiitis, Japanese journal of oriental medicine., 57：651-654, 2006 (inJapanese) .

Others
0630F001(H.Honda), J.Iwahashi, T.Kashiwagi, Y.Imamura, N.Hamada, T.Anraku, S.Ueda, T.Kanda, T.Takahashi,
S.Morimoto: Outbreak of human metapneumovirus infection in elderly inpatients in japan, J. Am. Geriatr. Soc.,
54:177-180, 2006.

Presentations at Conference
International Conference (Presentations)
0630I001

T.Kanda: Mao-to,j apanese herbal medicine, prolonged the survuival of viral myocarditis in mice by reduction ofcardiac tnf-α expression, 3rd Annual Symposium of the American Heart Association Council on Basic
Cardiovascular Sciences, (United States of America, '06.07)，American Heart Association, :53, 2006.

0630I002

S.Morimoto, T.Nakahashi, K.Okaishi, T.Takahashi, K.Nomura, T.Kanda, M.Okuro, H.Murai, T.Nishino,
M.Matsumoto: Hypotension induced by tilting of upper body in bedridden hypertensive elderly inpatients. Effectsof azelnidipine, The 21st scientific meeting of the international society of hypertension, (Fukuoka, '06.10).

0630I003(H.Honda), T.Takahashi, K.Nomura, Y.Imamura, N.Hamada, S.Morimoto: Outbreak of human metapneumovirus
infection in elderly inpatients in japan, The 5th east asian conference on infection control and prevention
EACIC2006, (Tokyo, '06.11).

－ 105 －

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

Director(Additional Post)

TAKASE Shujiro

Gastroenterology, Hepatology

Research Associate

MATSUDA Makoto

Endoscopic treatment of esophageal varices

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer－ 106 －

0650

Department of Rehabilitation Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMAGUCHI Masao

Gait analysis using EMG power spectrum．Sway paths of the center ofgravity；post hip surgery of the patient with osteoarthritis of the hip．
Clinical pathway of the patient with femoral neck fractur.

Senior Assistant Professor
Senior AssistantProfessor(Additional Post)

Establishment of evaluation for dysphagia.
NAKATA Minori

Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

－ 107 －

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Research Associate

AIKAWA Hirokazu

Field of Specialization

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Publications
Originals
0660B001

T.Sakuma, X.Gu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, K.Osanai, H.Toga, L.B.Ware, G.Folkesson,
M.A.Matthay: Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine, Crit.
Care Med., 34:676-681, 2006.

0660B002

J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami,
I.Yamamoto: Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lungadenocarcinomas, J. Nucl. Med., 47:419-425, 2006.

0660B003

M.Sagawa, K.Higashi, M.Sugita, Y.Ueda, S.Maeda, H.Toga, T.Sakuma: Fluorodeoxyglucose uptake correlates withthe growth pattern of small peripheral pulmonary adenocarcinoma, Surg Today, 36:230-234, 2006.

0660B004

X.Gu, Z.Wang, J.Xu, S.Maeda, M.Sugita, M.Sagawa, H.Toga, T.Sakuma: Denopamine stimulates alveolar fluid
clearance via cystic flbrosis transmembrane conductance regulator in rat lungs, Respirology, 11:566-571, 2006.

Reviews
0660C001

M.Sagawa, M.Sugita, S.Marda, K.Usuda, T.Sakuma: Is board certification system of thoracic CT screening
necessary?, The journal of thoracic CT screening., 13:113-115, 2006 (in Japanese) .

0660C004

M.Sagawa, I.Tsuji, H.Aikawa, S.Maeda, K.Usuda, T.Sakuma: Quality control of cancer screening, Proceedings of
the Society for Clinical and Biostatistical Research., 26：22-27, 2006 (in Japanese) .

Case Reports
0660D001

M.Sagawa, T.Donjo, T.Isobe, S.Notake, M.Nakai, M.Sugita, S.Maeda, T.Sakuma: Bilateral vocal cord paralysis
after lung cancer surgery with a double-lumen endotracheal tube: a life-threatening complication, J. Cardiothorac.
Vasc. Anesth., 20:225-226, 2006.

0660D002

Z.Wang, X.Jin, Y.Machida, H.Aikawa, M.Sagawa, K.Higashi, H.Saito, T.Kosaka, S.Takashima, T.Sakuma:
Colorectal cancer identified by FDG-PET during preoperative axamination for lung cancer: report of two cases, J.
Kanazawa. Med. Univ., 31:144-146, 2006.

0660D003

M.Sugita, M.Sagawa, Y.Ueda, K.Higashi, T.Sakuma: Localized bronchioloalveolar carcinoma with small foci ofactive fibroblastic proliferation, Respiration, 73:694-697, 2006.

0660D004

M.Sagawa, M.Sugita, S.Maeda, T.Sakuma: Two-staged treatment of bronchial carcinoid without pulmonary
parenchymal resection, J. Thorac. Cardiovasc. Surg., 131:753-754, 2006.
－ 108 －

0660D005

S.Maeda, M.Sagawa, M.Sugita, T.Sakuma: Surgical approach for lung cancer with multiple pulmonary nodules, Ｔhe
Japanese journal of thoracic surgery., 59：31-35, 2006 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0660H001

T.Sakuma: Protective effects of endogenous catecholamine on alveolar fluid balance in acute pancreatitis andhypoxia in rats, 3rd International Symposium on Respiratory Diseases, (Shanghai, '06.11)，J. Organ Dysfunction,
ISRD 2006Abstract:1-5, 2006.

International Conference (Presentations)
0660I001

T.Sakuma, J.Xu, Z.Wang, S.Maeda, M.Sugita, M.Sagawa, M.Shimazaki, Y.Ueda: Mechanisms responsible for acutepancreatitis-stimulated alveolar fluid clearance capacity in rat lungs, Experimental Biology, (San Francisco,'06.04).

0660I002

M.Iguchi, H.Kida, M.Saito, Y.Machida, K.Kojima, Y.Tachi, R.Hatta, K.Nakagawa, K.Tsuchihara, T.Tobe, T.Seki,
M.Takahashi, J.Huang, K.Osanai, H.Toga, M.Sagawa, T.Sakuma, Y.Ueda: Clinical evaluation of micropapillaryadenocarcinoma of the lung, 11th Congress of the Asian Pacific Society of Respirology, (kyoto, '06.11)，
Respirology, 11:A251, 2006.

－ 109 －

0670

Lifestyle-related Diseases Center

Title

Name

Field of Specialization

Director(Additional Post)

MATSUI Shinobu

cardiac function, echocardiography, myocardial metabolism

Professor(Additional Post)

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterosecretiol

Professor(Additional Post)

TAMURA Nobuki

Physical physiology(The exercise testing and prescription from thephysiological and biochemical research), Effects of the anemia on thephysical activitiy, Exercise therapy for the lifestyle-related disease,
Training for health Medical Education.

Professor(Additional Post)

UCHIDA Kenzo

endocrinology, hypertension and adrerol gland,diabete.

Senior AssistantProfessor(Additional Post)

NAKANISHI Yumiko

Research Associate

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology.

Research Associate

KITADA Munehiro

diabetes, hypertension.

Faculty

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

Publications
Originals
0670B001

M.Nakashima, K.Miura, T.Sakai, M.Bansho, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Attiude to smoking
and effect of anti-smoking education in elementary school 6th grade students, Hokuriku Japanese Journal of Public
Health., 32:73-78, 2006 (in Japanese) .

0670B002

K.Miura, H.Myogadani, Y.Kadoya, M.Hayashi, M.Motoya, M.Kuzumaki, M.Yoneda, T.Mitsui, M.Nishijo,
Y.Morikawa, Y.Nakanishi, M.Nakashima, H.Nakagawa: Effectiveness of lifestyle modification programs for control ofblood pressure: A non-randomized controlled trial in Komatsu, Japan, Japanese Journal of Public Health., 53:533542, 2006 (in Japanese) .

0670B003

F.Ueda, N.Tamura, T.Yamashina: A Report on the Physical Fitness and Motor Ability of Kanazawa Medical
University Students(XXXII), Mem. Lib. Kanazawa Med. Univ., 34:35-42, 2006 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
0670H001(H.Akazawa), Y.Qin, T.Yasuda, Y.Zou, S.Kudoh akazawa, I.Komuro: Molecular basis of inverse agonist activity of
AT1 receptor blockers, Gordon conference, (Italy, '06.09).

－ 110 －

0680

Medical Genetic Center

Faculty
Title

Name

Field of Specialization

Director(Additional Post)

KAKIMUMA Hiroaki

child neurology, inborn errors of metabolism, congenital malformation,
medical genetics

ITO Masatsune

child endocrinology

SATO Hitoshi

clinical virology, child infectious disease

Research
Associate(Additional Post)
Research
Associate(Additional Post)

Publications
Case Reports
0680D001

E.Koh, H.Sato, H.Takahashi: A case of kawasaki disease associated with an aseptic meningitis during intravenous
immunoglobulin therapy, Progress in Medicine, 26:1537-1540, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0680I001

H Kakinuma, M Itoh, H Takahashi, A Hori: REPETITIVE AXIAL MYOCLONUS IN A BOY WITH THE MCT8GENE MUTATION, 10th International Child Neurology Congress, (Montreal, '06.06)，Neuropediatrics,
26(Suppl.1):S97, 2006.

0680I002

C.Kitaoka, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Elevation ofbrain natriuretic peptitde in children with bronchial asthma attack., The First Asia-Pacific Congress of Pediatric
Cardiology and Cardiac Surgery, (Bangkok, '06.11).

0680I003

C.Akita, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Safety andEfficacy of Dexmedetomidine and low-dose Propofol combination for child cardiac catheterizations., The First
Asis-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, (Bangkok, '06.11).

－ 111 －

Medical0740

Research

Institute

Division of Human Genetics (Biochemistry)

Faculty
Title

Name

Professor

KUHARA Tomiko

Associate Professor

SHINKA Toshihiro

Senior Assistant Professor

INOUE Yoshito

Researcher

OHSE Morimasa

Field of Specialization
Human metabolome analysis for diagnosis of metabolic disorders andpersonalized medicine
Chemical diagnosis of metabolic disorders by mass spectrometry(Tyrosinosis, Metabolic disorders of fatty acid beta oxidation,
Acylcarnitine analysis, Sulfated bile acids analysis)
Chemical diagnosis and follow up study for metabolic disorders (ureacycle disorders, prenatal diagnosis of organic acidemias, Canavan
disease, optical isomer analysis)
Development of data handling method from a mass analysis
measurement value to evaluation value in diagnosis software

Keywords of Researchmetabolomics, metabolome, human genetics, mass spectrometry, inborn errors of metabolism, genetic disease, inheritedmetabolic disorders, molecular diagnosis, organic acidemia, gas chromatography-mass spectrometry, chemical diagnosis,
pilot study of neonatal screening, diagnosis of inborn errors of metabolism, prenatal diagnosis, tailor-made medicine,
personalized medicine, stable isotope dilution, soft ionization mass spectrometry, tandem mass spectrometry, electrosplay
ionization mass spectrometry, 5-fluorouracil toxicity, metabolic profiling, aminoacidemia/aminoaciduria, disorders of purine
and pyrimidine degradation, valproic acid, fatty acid β-oxidation, carnitine, acylcarnitine, diabetes mellitus, ureasepretreatment

Books
0740A001

T. Kuhara: Simultaneous diagnosis of inborn errors of purine & pyrimidine metabolism-Mass spectrometricmetabolome analysis, Genetic Errors Associated with Purine and Pyrimidine Metabolism in Humans: Diagnosis andTreatment, (Y. Moriwaki ed), 173-196, Research Signpost, India, 2006.

Publications
Originals
0740B001

Y. Inoue, T. Shinka, M. Ohse, H. Ikawa, T. Kuhara: Application of optical isomer analysis by diastereomer
derivatization GC/MS to determine the condition of patients with short bowel syndrome, J. Chromatogr. B Analyt.
Technol. Biomed. Life Sci., 838:37-42, 2006.

Others
0740F001(S. Liammongkolkul), P. Wasant, T. Shinka, T. Kuhara, I. Matsumoto: Tyrosinemia type I in Thailand - A report of
4 cases, Japanese Journal for inherited metabolic diseases., 22:56-58, 2006.

－ 112 －

Presentations at Conference
International Conference (Synposium)
0740H001(M. Fujiwara), T. Nemoto, T.Kuhara: Metabolic profiling using NMR-based multivariate analysis and its clinicalapplication combined with Mass spectroscopy, 20th IUBMB International Congress of Biochemistry and Molecular
Biology and 11th FAOBMB Congress, (Kyoto, '06.06)，"20th IUBMB International Congress of Biochemistry andMolecular Biology and 11th FAOBMB Congress, ABSTRACTS", 850, 2006.

0740H002

T.Kuhara: Metabolome-based chemical diagnosis of IEM, The 10th International Congress of Inborn Errors ofMetabolism, (Chiba, '06.09)，J. Inherit. Metab. Dis., 29 (Suppl 1):18, 2006.

International Conference (Presentations)
0740I001

T.Kuhara, Y.Inoue, M.Ohse, T.Shinka, T. Inokuchi, K. Aoki, K. Tashiro, M. Inaba, A. Fumimori, M. Tetsuo: A
pilot study of newborn screening and chemical diagnosis by GC/MS analysis of urine, The 6th Meeting of theInternational Society for Neonatal Screening, (Awaji, '06.09)，"The 6th Meeting of the International Society for
Neonatal Screening, Program and Abstracts", 171, 2006.

0740I002(P. Wasant), S. Liammongkolkul, A. Sathienkijkarnchai, T.Shinka: Glutaric aciduria type I in a Thai infant, The
10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J. Inherit. Metab. Dis., 29 (Suppl
1):104, 2006.

0740I003(P. Wasant), S. Liammongkolku, T. Shinka, I. Matsumoto: Multiple carboxylase deficiency in a Thai infant: firstreported case, The 10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J. Inherit. Metab.
Dis., 29 (Suppl 1):104, 2006.

0740I004(P. Wasant), S. Liammongkolkul, EW. Naylor, T. Shinka: Isovaleric acidemia in Thai infants: a report of 5 cases,
The 10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J. Inherit. Metab. Dis., 29 (Suppl
1):105, 2006.

0740I005(P. Wasant), S. Liammongkolkul, T. Shinka: Mitochondrial acetoacetyl-CoA thiolase (MAT) deficiency in a Thaiboy: first reported case, The 10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J.
Inherit. Metab. Dis., 29 (Suppl 1):120, 2006.

0740I006(S. Liammongkolkul), P. Wasant, T. Shinka: D-Glyceric aciduria in Thai infant with vesical stone: first reported
case, The 10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J. Inherit. Metab. Dis, 29(Suppl 1):123, 2006.

0740I007(P. Wasant), S. Liammongkolkul, T. Shinka, I. Matsumoto: Fructose-1,6-bisphosphatase deficiency (FBP1) in Thai
infant: first reported case, The 10th International Congress of Inborn Errors of Metabolism, (Chiba, '06.09)，J.
Inherit. Metab. Dis., 29 (Suppl 1):124, 2006.

－ 113 －

0750

Division of Human Genetics (Clinical Medicine)

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KAKIMUMA HiroakiChild neurology, inborn errors of metabolism, clinical genetics

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine

Research Associate

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Keywords of Research
genetic counseling, genetic service, prenatal diagnosis, congenital abnormality

Outline of Research
英文なし。

Publications
Originals
0750B001

A Kobayashi, H Kakinuma, H Takahashi: Three novel and six common mutation in 11 patients with methylmalonicacidemia, Pediatr. Int., 48:1-4, 2006.

0750B002(Y.Purwosunu), A.Sekizawa, A.Farina, T.Okai, H.Takabayashi, P.Wen, H.Yura, M.Kitagawa: Enrichment of NRBC
in maternal blood: a more feasible method for noninvasive prenatal diagnosis, Prenat. Diagn., 26:545-547, 2006.

0750B003(T.Tsujie), M.Takemura, T.Kimura, K.Shimoya, T.Tsutsui, K.Ogita, M.Ozaki, Y.Murata: Rapid detection oftrisomy 21 by gene dosage analysis using quantitative real-time polymerase chain reaction, J. Obstet. Gynaecol.
Res., 32:368-372, 2006.

Reviews
0750C001

W.Peng, H.Takabayashi, K.Ikawa: Whole genome amplification from single cells in preimplantation genetic
diagnosis and prenatal diagnosis, Eur. J. Obstet. Gynecol. Reprod. Biol., 131:13-20, 2006.

0750C003

H.Kakimuma, E.Takase, M.Kita, M.Ozaki, H.Takahashi: Purpose of genetic testing and roles of genetic counseling,
J. Kanazawa. Med. Univ., 31:119-123, 2006 (in Japanese) .

Case Reports
0750D001

H.Kakinuma, T.Fujiki, T.Nakamura, H.Takahashi: Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy
due to neonatal asphyxia, Pediatr. Int., 48:631-633, 2006.

0750D002(M.Nakagawa), K.Hashimoto, H.Ohira, T.Hamanaka, M.Ozaki, N.Suehara: Prenatal diagnosis of trisomy 9, Fetal.
Diagn. Ther., 21:68-71, 2006.

0750D003

T.Akai, K.Yamamoto, H.Iizuka, S.Kawakami, J.Yoshida, H.Kakimuma, H.Yaguchi, T.Ozawa: Syndromic
craniosynostosis with elbow joint contracture, Pediatr Neurosurg, 42:108-112, 2006.

－ 114 －

Presentations at Conference
International Conference (Presentations)
0750I001

H Kakinuma, M Itoh, H Takahashi, A Hori: REPETITIVE AXIAL MYOCLONUS IN A BOY WITH THE MCT8GENE MUTATION, 10th International Child Neurology Congress, (Montreal, '06.06)，Neuropediatrics,
26(Suppl.1):S97, 2006.

0750I002

M.Hashimoto, T.Matsui, T.Hamada, M.Ozaki, K.Iwabuchi, T.Date: Human PKU-β/TLK1 contributes to proper
chromosomal segregation and positioning of centrosomes during mitosis, 20th IUBMB International Congress ofBiochemistry and Molecular Biology, (Kyoto, '06.06).

0750I003

C.Kitaoka, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Elevation ofbrain natriuretic peptitde in children with bronchial asthma attack., The First Asia-Pacific Congress of Pediatric
Cardiology and Cardiac Surgery, (Bangkok, '06.11).

0750I004

C.Akita, H.Sato, J.Yamamura, Toshimi Nakamura, Tsuneyuki Nakamura, H.Kakinuma, H.Takahashi: Safety andEfficacy of Dexmedetomidine and low-dose Propofol combination for child cardiac catheterizations., The First
Asis-Pacific Congress of Pediatric Cardiology and Cardiac Surgery, (Bangkok, '06.11).

－ 115 －

0770

Division of Core Facility (Radioisotope Center)

Faculty
Title

Name

Field of Specialization

Associate
Professor(Additional Post)

YOSHITAKE Yoshino

microRNA involved in angiogenesis, Functions of FGF2 binding
proteinSenior Assistant Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Keywords of Research
RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis,
Energy-filtering electron microscopy, Element mapping, Ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, centrosome, tumor growth angiogenesis, micro RNA

Outline of Research
Quality control of genetic information

Publications
Originals
0770B001

K.Fujimura, N.Segami, Y.Yoshitake, N.Tsuruoka, K.Kaneyama, J.Sato, S.Kobayashi: Electrophoretic separation of
the synovial fluid proteins in patients with temporomandibular joint disorders, Oral Surg. Oral Med. Oral Pathol.
Oral Radiol. Endod., 101:463-468, 2006.

Presentations at Conference
International Conference (Presentations)
0770I001

Y.Ishigaki, Z.Xia: DNA microarray analysis with NMD suppression in humana cells carrying nonsense mutation,
20th IUBMB, (Kyoto, '06.06).

－ 116 －

0780

Division of Core Facility (Experimental Animal Center)

Faculty
Title

Name

Professor(Additional Post)

MATSUI Shinobu

Senior Assistant Professor

SO Shihei (ZONG zhiping)

Field of Specialization

Publications
Originals
0780B001

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0780B002

S.Matsui, L.Larsson, M.Hayase, S.Katsuda, K.Teraoka, T.Kurihara, H.Murano, K.Nisikawa, M.Fu: Specificremoval of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy
improved cardiac structure and function, J. Mol. Cell. Cardiol., 41:78-85, 2006.

0780B003

S.Matsui, M.Fu: Pathological importance of anti-G-protein coupled receptor autoantibodies, Int. J. Cardiol.,
112:27-19, 2006.

－ 117 －

0790

Division of Core Facility (Morphological Equipment Center)

Faculty
Title

Name

Field of Specialization

Professor

ISHIKAWA Yoshimaro

Senior Assistant Professor

KURIHARA Takayuki Mechanism of Chromosomal Instability

Publications
Originals
0790B001

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0790B002

S.Matsui, L.Larsson, M.Hayase, S.Katsuda, K.Teraoka, T.Kurihara, H.Murano, K.Nisikawa, M.Fu: Specificremoval of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy
improved cardiac structure and function, J. Mol. Cell. Cardiol., 41:78-85, 2006.

0790B003

K.Iwabuchi, M.Hashimoto, T.Matsui, T.Kurihara, H.Shimizu, N.Adachi, M.Ishiai, K-I.Yamamoto, H.Tauchi,
M.Takata, H.Koyama, T.Date: 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70
or Artemis., Genes Cells, 11: 935-948, 2006.

Case Reports
0790D001

K.Sato, Y.Ueda, A.Sakurai, Y.Ishikawa, S.Kaji, T.Nojima, S.Katsuda: Adenoid cystic carcinoma of the maxillarysinus with gradual histologic transformation to high-grade adenocarcinoma: a comparative report withdedifferentiated carcinoma, Virchows Arch., 448:204-208, 2006.

－ 118 －

0800

Division of Core Facility (High-Tech Research Center)

Faculty
Title

Name

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Field of Specialization

KOHNO Hiroyuki
NISHIJO Muneko

Researcher

OKUWA Takako

Researcher

WU Jialu

Researcher

YASUI Yumiko

Publications
Originals
0800B001(S.Omote), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono, E.Kobayashi, N.Nogawa: Urinary type I collagen crosslinked N-telopeptides in inhabitants 18Years after cessation of exposure to cadmium in Japan, Bull. Environ.
Contam. Toxicol., 76:187-94, 2006.

0800B002

H.Nakagawa, M.Nishijo, Y.Morikawa, K.Miura, K.Tawara, J.Kuriwaki, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa:
Urinary cadmium and mortality among inhabitants of a cadmium-polluted area in Japan, Environ Res, 100:323-329,
2006.

0800B003(M.Uetani), E.Kobayashi, Y.Suwazono, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Smoking does not influencecadmium concentrations in blood and urine in relatively high levels of environmental cadmiun areas in Japan, Biol
Trace Elem Res, 110:107-118, 2006.

0800B004

M.Nishijo, Y.Morikawa, H.Nakagawa, K.Tawara, K.Miura, T.Kido, A.Ikawa, E.Kobayashi, K.Nogawa: Causes ofdeath and renal tubular dysfunction in residents exposed to cadmium in the environment, Occup Environ Med,
63:545-550, 2006.

0800B005(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose for renal dysfunction in a cadmium non-polluted area in Japan, J. Appl. Toxicol., 26:351-355,
2006.

0800B006(M.Uetani), E.Kobayashi, Y.Suwazaono, R.Honda, M.Nishijo, H.Nakagawa, T.Kido, K.Nogawa: Tissue cadmium(Cd) concentrations of people living in a Cd polluted area, Japan, Biometals, 19:521-525, 2006.

0800B007

M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa: Theiler's murine encephalomyelitis virus leader proteinamino acid residue 57 regulates subgroup-specific virus growth on BHK-21 cells, J. Virol., 80: 12025-12031,
2006.

0800B008

T.Tanaka, H.Kohno, R.Suzuki, K.Hata, S.Sugie, N.Niho, K.Sakano, M.Takahashi, K.Wakabayashi: Dextran sodium
sulfate strongly promotes colorectal carcinogenesis in ApcMin/+ mice: Inflammatory stimuli by dextran sodium sulfate
results in development of multiple colonic neoplasms, Int. J. Cancer., 118:25-34, 2006.

0800B009(K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, T.Kuno, Y.Hirose, A.Hara, H.Mori: Lack of enhancing effects
of degraded λ-carrageenan on the development of β-catenin-accumulated crypts in male DBA/2J mice initiatedwith azoxymethane, Cancer Lett., 238:69-75, 2006.

0800B010(K.Hata), T.Tanaka, H.Kohno, R.Suzuki, S.H.Qiang, Y.Yamada, T.Oyama, T.Kuno, Y.Hirose, A.Hara, H.Mori:β-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice, Cancer Lett., 239:123-128, 2006.

0800B011

R.Suzuki, H.Kohno, S.Sugie, H.Nakagama, T.Tanaka: Strain differences in susceptibility to azoxymethane anddextran sodium sulfate-induced colon carcinogenesis in mice, Carcinogenesis, 27:162-169, 2006.

－ 119 －

0800B012

R.Suzuki, H.Kohno, M.Suzui, N.Yoshimi, H.Tsuda, K.Wakabayashi, T.Tanaka: An animal model for the rapid
induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its
potential use for preclinical chemoprevention studies, Carcinogenesis, 27:619-630, 2006.

0800B013

H.Kohno, R.Suzuki, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka: Dietary administration withprenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice, Int. J. Cancer.,
118:2936-2942, 2006.

0800B014(S.Miyamoto), H.Kohno, R.Suzuki, S.Sugie, A.Murakami, H.Ohigashi, T.Tanaka: Preventive effects of chrysin on
the development of azoxymethane-induced colonic aberrant crypt foci in rats, Oncol. Rep., 15:1169-1173, 2006.

0800B015

Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita: Growth inhibition and apoptosis induction by all-transconjugated linolenic acids on human colon cancer cells, Anticancer Res., 26:1855-1860, 2006.

0800B016

R.Suzuki, Y.Yasui, H.Kohno, S.Miyamoto, M.Hosokawa, K.Miyashita, T.Tanaka: Catalpa seed oil rich in
9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced byazoxymethane in rats, Oncol. Rep., 16:989-996, 2006.

0800B017

R.Suzuki, H.Kohno, Y.Yasui, K.Hata, S.Sugie, S.Miyamoto, K.Sugawara, T.Sumida, Y.Hirose, T.Tanaka: Diet
supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions
and fatty liver in male db/db mice, Int. J. Cancer., 120:252-258, 2006.

0800B018

Y.Yasui, M.Hosokawa, H.Kohno, T.Tanaka, K.Miyashita: Troglitazone and 9cis,11trans,13trans-conjugatedlinolenic acid: Comparison of their antiproliferative and apoptosis-inducing effects on different colon cancer celllines, Chemotherapy, 52:220-225, 2006.

0800B019(M.Ikeda), K.Masumura, K.Matsui, H.Kohno, K.Sakuma, T.Tanaka, T.Nohmi: Chemopreventive Effects of Nobiletin
against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta
Transgenic Mice, Genes and Environment, 28:84-91, 2006.

0800B020(E.Kobayashi), Y.Suwazono, M.Uetani, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Tolerable level of lifetime
cadmium intake estimated as a benchmark dose low, based on excretion of β2-microglobulin in the cadmiumpolluted regions of the Kakehashi River Basin, Japan, Bull. Environ. Contam. Toxicol., 76:8-15, 2006.

0800B021(E.Kobayashi), Y.Suwazono, M.Uetani, T.Inaba, M.Oishi, T.Kido, M.Nishijo, H.Nakagawa, K.Nogawa: Estimation ofbenchmark dose as the threshold levels of urinary cadmium, based on excretion of total protein, β２-microglobulin,
and N-acetyl-β-D-glucosaminidase in cadmium nonpolluted regions in Japan, Environ Res, 101:401-406, 2006.

0800B022(F.Beppu), M.Hosokawa, L.Tanaka, H.Kohno, T.Tanaka, K.Miyashita: Potent inhibitory effect of trans9, trans11
isomer of conjugated linoleic acid on the growth of human colon cancer cells, J. Nutr. Biochem., 17:830-836, 2006.

0800B023(T.Miyamoto), E.Kobayashi, Y.Suwazono, M.Uetani, M.Nishijo, K.Miura, H.Nakagawa, K.Nogawa: Changes inurinary excretions of cadmium, copper, and zinc in Japanese workers., Arch. Environ. Occup. Health., 61:251222, 2006.

0800B024

M.Nakashima, K.Miura, T.Sakai, M.Bansho, Y.Morikawa, M.Nishijo, Y.Nakanishi, H.Nakagawa: Attiude to smoking
and effect of anti-smoking education in elementary school 6th grade students, Hokuriku Japanese Journal of Public
Health., 32:73-78, 2006 (in Japanese) .

0800B025

K.Miura, H.Myogadani, Y.Kadoya, M.Hayashi, M.Motoya, M.Kuzumaki, M.Yoneda, T.Mitsui, M.Nishijo,
Y.Morikawa, Y.Nakanishi, M.Nakashima, H.Nakagawa: Effectiveness of lifestyle modification programs for control ofblood pressure: A non-randomized controlled trial in Komatsu, Japan, Japanese Journal of Public Health., 53:533542, 2006 (in Japanese) .

Reviews
0800C001

M.Takano-Maruyama, Y.Ohara, K.Asakura, T.Okuwa: Leader (L) and L* proteins of Theiler's murine
encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities, J. Neuroinflammation., 3:1926, 2006.

0800C002

T.Tanaka, S.Miyamoto, R.Suzuki, Y.Yasui: Chemoprevention of colon carcinogenesis by dietary non-nutritive
compounds, Curr. Topics Nutraceut. Res., 4:127-152, 2006.

－ 120 －

0800C003(S.Satarug), M.Nishijo, JM.Lasker, RJ.Edwards, MR.Moore: Kidney dysfunction and hypertension:role forcadmium,P450 and heme oxygenases?, Tohoku J. Exp. Med., 208:179-202, 2006.

Presentations at Conference
International Conference (Synposium)
0800H001

H.Kohno, R.Suzuki, S.Miyamoto, T.Sumida, K.Sugawara, S.Sugie, T.Tanaka: Citrus unshiu segment membrane
suppresses azoxymethane-induced colonic aberrant crypt foci and β-catenin accumulated crypts in male db/db
mice, 4th Regional APOCP Conference, Synposium IV-Pathlogy and Chemoprevention, (Nagoya, '06.01).

International Conference (Presentations)
0800I001(S.Miyamoto), R.Suzuki, H.Kohno, S.Sugie, T.Tanaka: Dietary auraptene inhibits azoxymethane-induced colonic
aberrant crypt foci in female db/db mice, 4th Regional APOCP Conference, (Nagoya, '06.01).

0800I002

H.Kohno, R.Suzuki, S.Miyamoto, S.Sugie, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka: Suppression ofcolitis-related mouse colon carcinogenesis by dietary administration with prenyloxycoumarins, auraptene andcollinin, 97th Annual Meeting of American Association for Cancer Research, (Washington, DC, '06.04).

0800I003

S.Sugie, R.Suzuki, H.Kohono, T.Tanaka, H.Mori: Modifying effect of thiol compounds on diethylnitrosamine(DEN)-phenobarbital (PB) induced rat hepatocarcinogenesis, 97th Annual Meeting of American Association forCancer Research, (Washington, DC, '06.04).

0800I004

T.Tanaka, R.Suzuki, H.Kohno, K.Hata, S.Sugie, S.Miyamoto, K.Sugawara, T.Sumida, Y.Hirose: Diet supplemented
with citrus unshiu segment membrane suppresses azoxymethane-induced colonic aberrant crypt foci and betacatenin accumulated crypts in male db/db mice, 97th Annual Meeting of American Association for Cancer
Research, (Washington, DC, '06.04).

0800I005

M.Nishijo, H.Nakagawa, R.Honda: A trial for a global standard health management for Cd pollution, Health risk
management for environment and labour, (Tokyo, '06.06)，URMPM special conference, 52, 2006.

0800I006

M. Takano-Maruyama, T. Okuwa, K. Asakura, Y. Ohara: Theiler's murine encephalomyelitis virus subgroupspecific growth on BHK-21 cells is rehulated by amino acid 57 within the leader protein, 7th International
Symposium on NeuroVirology, (Philadelphia, '06.06)，J. NeuroVirol, 12:80, 2006.

0800I007

M.Nishijo, H.Nakagawa, R.Naganuma, K.Tawara, T.Kido, H.Suzuki: An epidemiological study on health effects bydioxin in vietnam;conparison of contrast acuity between inhabitants of herbicide sprayed and non-sprayed areas,
26th International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0800I008

M.Nishijo, H.Nakagawa, Y.Morikawa, K.Tawara, J.Kuriwaki, E.Hori, H.Nishijo: Effect of 2,3,7,8thtrachlorodibenzo-p-dioxin exposure during pregnancy on the neurodevelopment of rat off-springs, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0800I009

M.Nishijo, H.Nakagawa, K.Tawara, T.Kido, R.Naganuma: Areal differences of concentration levels ofpolychlorinated debenzo-p-dioxins and dibenzofurans in human breast milk from Vietnam and Japan, 26th
International sumposium on halogenated persistent organic pollutants, (Oslo, '06.08)，26th International
sumposium on halogenated persistent organic pollutants, 2006.

0800I010

T. Okuwa, M. Takano-Maruyama, K. Asakura, H. Murayama, Y. Ohara: Generation of a mutant of Theiler's
murine encephalomyelitis virus (TMEV) causing demyelination in the brain of susceptible mice, The 8thInternational Congress of Neuroimmunology, (Nagoya, '06.10).

0800I011

Y.Yasui, H.Kohno, R.Suzuki, S.Miyamoto, S.Sugie, M.Curini, F.Epifano, F.Maltese, S.P.Gonzales, T.Tanaka:
Inhibition of colitis-related mouse colon carcinogenesis by dietary administration with prenyloxycoumarins,
auraptene and collinin, The Kadota Fund International Forum 2006, (Inuyama, '06.11).

－ 121 －

0900

Division of Cell Medicine

Faculty
Title

Name

Field of Specialization

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle,transformation

Research Associate

MIYAGOSHI Minoru

Cell biology

Keywords of Research
polyploid cells, polyploidization, Meth-A cells, V79 cells, triploid cells, tetraploid cells, octaploid cells, H-1(ES)cells

Outline of Research
Study of polyploid cells

Publications
Originals
0900B001

K.Fujikawa-Yamamoto: An hypothesis about genome structures in mammalian polyploid cells based on a newconcept that genome is fractal of six hierarchies, Med. Hypotheses., 66:337-344, 2006.

0900B002

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi: Reversible alteration in morpholoby and proliferation of mouse
H-1 (ES) cells in DME versus L15F10 medium, J. Kanazawa. Med. Univ., 31:138-143, 2006.

0900B003

K.Fujikiawa-Yamamoto, M.Miyagoshi, H.Yamagishi: Polyploidization of mouse H-1 (ES) cells by demecolcine andK-252a, Cytologia, 71:399-406, 2006.

0900B004

K.Kawamura, N.Morita, C.Domiki, K.Fujikawa-Yamamoto, M.Hashimoto, K.Iwabuchi, K.Suzuki: Induction ofcentrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure, Cancer Sci., 97:252258, 2006.

0900B005

M.Miyagoshi, K.Fujikawa-Yamamoto: The reversion to diploid cells from established triploid V79 cells, Cell Prolif.,
39:421-428, 2006.

Reviews
0900C001

K.Fujikawa-Yamamoto, M.Miyagoshi: Cell cycle analysis using flow cytometory Ⅰ-relationship between fraction
and duration-, Cytometry Res, 16:33-36, 2006 (in Japanese) .

0900C002

K.Fujikawa-Yamamoto, M.Miyagoshi: Cell cycle analysis using flow cytometry Ⅱ-BrdU continuous labeling andcell cycle time-, Cytometry Res, 16:37-41, 2006 (in Japanese) .

0900C003

K.Fujikawa-Yamamoto, M.Miyagoshi: Cell cycle analysis using flow cytometry Ⅲ -stathomokinetic analysis-,
Cytometry Res, 16:43-49, 2006 (in Japanese) .

－ 122 －

Presentations at Conference
International Conference (Presentations)
0900I001

K.Fujikawa-Yamamoto, M.Miyagoshi: Harmony between experimental results and predictions from the hypothesis
about genome structures in mammalian polyploid cells based on a new concept that genome in fractal of six
hierarchies, 14th International Conference of the International Society of Differentiation, (Innsbruck, '06.10)，
Differentiation, 74: 468-468, 2006.

－ 123 －

0910

Division of Advanced Medicine

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Shinobu

Clinical cardiology

Professor

TOMOSUGI Naohisa

Clinical Nephrology

Associate Professor

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors

Keywords of Researchheart failure, cardiomyopathy, nerohumoral factor, immunity, autoantibody, spermatogenesis, cell cycle, epigenetics,
endocrine disruptors, meiosis

Outline of Research
1.Myocardial injury due to autoimmunity against G-protein-coupled receptor. Growing evidence suggested that G-proteincoupled receptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated
cardiomyopathy. Our study showed that specific removal of anti-G-protein coupled receptor autoantibodies improved
cardiac structure and function in experimental autoimmune cardiomyopathy.
2.Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.
However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has beendeveloped. Here, we employed surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOFMS) to analyze the expression of serum hepcidin in hemodialysis patients. Hepcidin-25 was found to accumulate in theserum of hemodialysis patients; this could contribute to the pathogenesis of renal anemia by decreasing the available ironfor hematopoiesis.
3.Histone modifications in meiotic prophase of spermatogenesis.

Publications
Originals
0910B001

I.Ishikawa, T.Hayama, S.Yoshida, M.Asaka, N.Tomosugi, M.Watanabe, H.Yamato, M.Sugano: Proteomic analysis of
rat plasma by SELDI-TOF-MS under the condition of prevention of progressive adriamycin nephropathy using oral
adsorbent AST-120, Nephron. Physiol., 103:125-130, 2006.

0910B002

S.Matsui, M.Fu, M.Hayase, S.Katsuda, N.Yamaguchi, K.Teraoka, T.Kurihara, H.Murano, N.Takekoshi: Transfer of
immune components from rabbit autoimmune cardiomyopathy into severe combined immunodeficiency (SCID) miceinduces cardiomyopathic changes, Autoimmunity, 39:121-128., 2006.

0910B003

I.Ishikawa, Y.Chikazawa, K.Sato, M.Nakagawa, H.Imamura, S.Hayama, H.Yamaya, M.Asaka, N.Tomosugi,
H.Yokoyama, K.Matsumoto: Proteomic analysis of serum, outflow dialysate and adsorbed protein onto dialysis
membranes (polysulfone and PMMA) during hemodialysis treatment using SELDI-TOF-MS, Am. J. Nephrol.,
26:372-380, 2006.

0910B004

S.Matsui, L.Larsson, M.Hayase, S.Katsuda, K.Teraoka, T.Kurihara, H.Murano, K.Nisikawa, M.Fu: Specificremoval of β1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy
improved cardiac structure and function, J. Mol. Cell. Cardiol., 41:78-85, 2006.

0910B005

N.Tomosugi, H.Kawabata, R.Wakatabe, M.Higuchi, H.Yamaya, H.Umehara, I.Ishikawa: Detection of serum
hepcidin in renal failure and inflammation by using ProteinChip System, Blood, 108:1381-1387, 2006.

0910B006

S.Matsui, M.Fu: Pathological importance of anti-G-protein coupled receptor autoantibodies, Int. J. Cardiol.,
112:27-19, 2006.
－ 124 －

Presentations at Conference
International Conference (Presentations)
0910I001

S.Matsui: Specific removal of beta 1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune
cardiomyopathy improved cardiac structure and function, World Congress of Cardiology 2006, (Barcelona, '06.09).

－ 125 －

0920

Division of Molecular Oncology and Virology

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor(Additional Post)

MOTOO Yoshiharu

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Research Associate

MURAKAMI Manabu

Molecular analysis and development of antiviral drugs: Mechanism ofantiviral action of RNAi

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, hepatitis C virus, flavivirus, Japanese encephalitis
virus, virus replication, RhoGDI, Rho family, Eomes, epithelial/mesenchymal, nonstructural protein NS3, RNA synthesis,
transfection, persistent infection, RNAi

Outline of Research
Molecular analyses of virus replication, carcinogenesis and metastasis

Publications
Originals
0920B001(J.Pei-Hong), Y.Motoo, N.Sawabu, T.Minamoto: Effect of gemcitabine on the expression of apoptosis-related genes
in human pancreatic cancer cells, World J. Gastroenterol., 12:1597-1602, 2006.

0920B002(J.Pei-Hong), Y.Motoo, S.Garcia, JL.Iovanna, MJ.Pebusque, N.Sawabu: Down-expression of tumor protein p53induced nuclear protein 1 in human gastric cancer, World J. Gastroenterol., 12: 691-696, 2006.

0920B003

J. F. Guo, K.Higashi, Y.Ueda, M.Oguchi, T.Takegami, H.Toga, T.Sakuma, H.Yokota, S.Katsuda, H.Tonami,
I.Yamamoto: Microvessel density : correlation with 18F-FDG uptake and prognostic impact in lungadenocarcinomas, J. Nucl. Med., 47:419-425, 2006.

0920B004

L.Dong: Identification and characterization of novel human recombinant monoclonal fab fragments specific ｆor EBVviral capsid antigen established by phage display, J. Kanazawa. Med. Univ., 31:172-178, 2006.

0920B005

T.Ota, M.Maeda, S.Suto, X.Zhou, M.Murakami, T.Takegami, M.Tatsuka: RhoGDIβ lacking the N-terminal
regulatory domain suppresses metastasis by promoting anoikis in v-src transformed cells., Clin. Exp. Metastasis.,23:323-334, 2006.

0920B006(Y.Ito), Y.Motoo, H.Yoshida, JL.Iovanna, Y.Nakamura, K.Kuma, A.Miyauchi: High level of tumour protein p53induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid, Pathology., 38:545-547,
2006.

0920B007(U.Tateishi), T.Hasegawa, T.Nojima, T.Takegami, Y.Arai: MRI features of extraskelal myxoid chondrosarcoma,
Skeletal Radiol., 35:27-33, 2006.

Reviews
0920C009

Y.Motoo, K.Tsutani: Is it possible to develop global clinical practice guidelines for traditional medicine?, Japanesejournal of oriental medicine., 57: 465-475, 2006 (in Japanese) .
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0920C011

T. Takegami: Japanese encephalitis vaccine, Antibiotics & chemotherapy., 22: 1389-1395, 2006 (in Japanese) .

Case Reports
0920D001

J.Yamakawa, J.Moriya, K.Kusaka, T.Itoh, Y.Motoo, T.Kanda: Effectiveness of goshajinkigan on the cold sensationand dysthesia in a case of nodular multiple angiitis, Japanese journal of oriental medicine., 57：651-654, 2006 (inJapanese) .

Presentations at Conference
International Conference (Synposium)
0920H001(A.Kanda), S.Sato, T.Takata, T.Ota, M.Tatsuka: Expression and distribution of Aurora-B in human oral squamouscell carcinoma cell line highly metastatic to lymph node., The 11th International Congress of Metastasis ResearchSociety Jointed with the 15th Annual Meeting of Japanese Association for Metastasis Research, (Hiroshima,'06.09).

0920H002

Y.Motoo: How to develop an international clinical practice guideline for lung cancer, WHO Workshop on Guideline
Development for Cancer, (Budapest, Hungary, '06.10).

International Conference (Presentations)
0920I001

Y.Motoo: Down-expression of TP53INP1 in human gastric cancer., American Society of Clinical OncologySymposium on Gastrointestinal Cancers (ASCO-GI), (San Francisco, CA, USA, '06.01).

0920I002

T.Ota, M.Maeda, M.Murakami, T.Takegami, A.Kanda, M.Tatsuka: RhoGDIβ lacking the N-terminal regulatory
domain suppresses metastasis by promoting anoikis in v-src transformed cells., The 11th International Congress ofMetastasis Research Society Jointed with the 15th Annual Meeting of Japanese Association for Metastasis
Research, (Hiroshima, '06.09).

0920I003

T. Takegami, M. Murakami, K. Kamimura, T. Ota: Japanese encephalitis virus isolation from mosquitoes in
Ishikawa, Japan and inhibitory effect of RNAi on JEV replication., 7th Asia-Pacific Congress of Medical Virology,(New Delhi, '06.11).

0920I004

Y.Motoo, T.Shimasaki: Molecular mechanisms of anti-tumor effect of gemciatbine hydrochloride on humanpancreatic cancer cells., The 28th World Congress of Internal Medicine, (Taipei, '06.11).

－ 127 －

0930

Division of Dermatomycology (Novartis Pharma)

Faculty
Title

Name

Field of Specialization

Visiting Professor

ISHIZAKI Hiroshi

Medical mycology

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology，Dermatomycosis

Senior AssistantProfessor(Additional Post)

KAWASAKI Masako

Medical mycology

Researcher

ANZAWA Kazushi

Medical mycology

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
未入力

Publications
Originals
0930B001(T. Uenotsuchi), S. Takeuchi, T. Matsuda, K. Urabe, T. Koga, H. Uchi, T. Nakahara, S. Fukagawa, M.Kawasaki,
H.Kajiwara, S.Yoshida, Y.Moroi, M.Furue: Differential induction of Th1-prone immunity by human dendritic cells
activated with Sporothrix schenckii of cutaneous and visceral origins to determine their different virulence, Int.
Immunol., 18：1637-1646, 2006.

0930B002(CJ.Jackson), T. Mochizuki, RC.Barton: PCR fingerprinting of Trichophyton mentagrophytes var. interdigitaleusing polymorphic subrepeat loci in the rDNA nontranscribed spacer, J. Med. Microbiol., 55：1349-1355, 2006.

0930B003(N.Umemoto), M.Kakurai, H.Yokokura, S.Toda, M.Osawa, H.Abe, Y.Hiratsuka, E.Okada, R.Azuma, Y.Wada,
M.Hayashi, T.Mochizuki, T.Demitsu: Analysis of dermatophyte flora for 5 years at Jichi Medical University Omiya
Medical Center in Saitama and identification of atypical dermatophytes using molecular biological Technique(PCRRFLP analysis), Jichi Medical School journal., 29:155-161, 2006 (in Japanese) .

Reviews
0930C003

T.Mochizuki, H.Tanabe, A.Wakasa, M.Kawasaki, K.Anzawa, H.Ishizaki: Survey of Trichophyton tonsurans
infection in Japan－Molecular epidemiology and factors affecting adequate hairbrush sampling－, The JapaneseSociety for Medical Mycology., 47：57-61, 2006 (in Japanese) .

Case Reports
0930D001(K.Haruna), Y.Shiraki, M.Hiruma, S.Ikeda, M. Kawasaki: A case of lymphangitic sporotrichosis occurring on bothforearms with a published work review of cases of bilateral sporotrichosis in Japan, J. Dermatol., 33：364-367,
2006.

0930D002

S.Watanabe, H.Tanabe, T.Mochizuki, M.Yanagihara, H.Ishizaki: Two Cases of Toe Web Infection by Pseudomonas
Aeruginosa, Skin research., 5：53-56, 2006 (in Japanese) .
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0930D003

M.Nakagawa, K.Takeda, M.Yanagihara, H.Ishizaki, T.Mochizuki, T.Iura, S.Kataoka: A case of viper bite that
occurred during pregnancy, Nishinihon j. dermatol., 68：40-42, 2006 (in Japanese) .

0930D004

M.Nakagawa, H.Tanabe, M. Yanagihara, H.Ishizaki, T.Mochizuki: A case of meningomyelocele diagnosed withmalum perforans pedis, Skin research., 5：22-26, 2006 (in Japanese) .

0930D011(M.Maeda), T.Mochizuki: A case of onychomycosis caused by Fusarium oxysporum infection, Nishinihon j.
dermatol., 68：652-655, 2006 (in Japanese) .

0930D012

H.Ogawa, S.Watanabe, S.Abe, H.Tanabe, T.Mochizuki: A case of external region basel cell carcinoma the study ofbasal cell carcinoma for past 15 years in our department, Skin research., 5：411-414, 2006 (in Japanese) .

0930D016

H.Tanabe, M.Terada, M.Hasei, H.Ogawa, K.Anzawa, M.Kawasaki, T.Mochizuki, N.Ishikura: Problems of hairbrush
test for monitoring of Trichophyton tonsurans infection, Skin research., 5：430-434, 2006 (in Japanese) .

Short Communications
0930E001(P.Campos-Macìas), R.Arenas, Me Vega-Memije, M. Kawasaki: Sporothrix schenckii Type 3D (mtDNA- RFLP）：
Report of an osteoarticular case, J. Dermatol., 33：295-299, 2006.

Presentations at Conference
International Conference (Presentations)
0930I001

M.Kawasaki: Genetic and phenotypic variations among F1 progenies of Arthroderma benhamiae, 16th Congress of
the International Society for Human and Animal Mycology, (Paris, '06.06).

0930I002

M.Kawasaki, A.Wakasa, K.Anzawa, H.Tanabe, T.Mochizuki, H.Ishizaki, S.Kagawa, B.Hemashettar: Multi-locus
analysis of infra- and inter-species variations among Trichophyton species, 16th Congress of the International
Society for Human and Animal Mycology, (Paris, '06.06).

0930I003

S.Watanabe, K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Strain typing of Fonsecaea pedrosoi strains by
PCR-RFLP analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0930I004

T.Mochizuki, M.Kawasaki, H.Tanabe, K.Anzawa, H.Ishizaki, J. Choi: Molecular epidemiology of Trichophyton
tonsurans isolation in Japan, 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0930I005

H.Ishizaki, M.Kawasaki, T.Mochizuki, A.Chakrabarti, R.Ungpakorn, J.Yamashita, C.Zaitz, H.Guerrero, C.Toriello,
R.Arenas: Mitochondrial DNA analysis of Sporothrix schenckii isolated from India, Thailand, Brazil, Guatemala,Colombia and Mexico., 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0930I006

K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Identification of species from scale from dermatophytosis lesions
by PCR-RFLP analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris,'06.06).

0930I007

K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Identification of dermatophytes in the nail by PCR-RFLP
analysis, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0930I008

K.Anzawa, M.Kawasaki, H.Tanabe, T.Mochizuki, H.Ishizaki: Genotype analysis of Candida albicans isolated fromthe human oral cavity, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06.06).

0930I009(Ｃ. Jackson), T.Mochizuki, R.Barton: Recent developments in the molecular subtyping of anthropophilicdermatophyte fungi, 16th Congress of the International Society for Human and Animal Mycology, (Paris, '06).

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0940

Division of Taxus Research (Kotosugi)

Faculty
Title

Name

Professor

NOBUKAWA Takahiro

Professor(Additional Post)

HIRAI Keiichi

Senior AssistantProfessor(Additional Post)SHIMADA Hiroki

Field of Specialization

Keywords of Research
Taxaceae, Taxus, Pseudotaxus, Hongdoushan, Kotosugi, Sennenichii, lignan, taxiresinol, secoisolariciresinol, isotaxiresinol,
DPPH free radical, nitric oxide, taxane diterpenoids, antiproliferative activity, apoptosis, hepatoprotective effect, TNF-α,phytoestrogen, biochemical marker, hypoglycemic effectPublications
Originals
0940B001(J.Yin), Y.Tezuka, Subehan, L.Shi, M.Nobukawa, T.Nobukawa, S.Kadota: In vivo anti-osteoporotic activity of
isotaxiresinol, a lignana from wood of taxus yunnanensis, Phytomedicine, 13(2006)37-42, 2006.

0940B002(J.Koyama), I.Morita, N.Kobayashi, K.-I.Hirai, E.Simamura, T.Nobukawa, S.Kadota: Antiallergic activity of
aqueous extracts and constituents of Taxus yunnanensis., Biol.Pharm.Bull., 29:2310-2312, 2006.

0940B003(L.Shi), Y.Tezuka, Subehan, JY.Ueda, T.Miyahara, J.YIN, T.Nobukawa, S.Kadota: Inhibitory effect of Kampo
medicines on bone resorption in vitro and preventive effect on bone loss in vivo, J. Trad. Med., 23(3), 92-100,
2006.

0940B004

K.Ikai, E.Simamura, K-I.Hirai: The mechanisms of anti-cancer activity by the natural constituents of Taxus
yunnanensis, J. Kanazawa. Med. Univ., 31:165-171, 2006 (in Japanese) .

Others
0940F001(JY.Ueda), S.Awale, Y.Tezuka, E.Simamura, K.-I.Hirai, T.Nobukawa, A.Sato, S.Kadota: Growth inhibitory activityof wood of Taxus yunnanensis and its liquid chromatography fourier-transform mass spectrometry analysis, PlantaMed., 72:1241-1244, 2006.

Presentations at Conference
International Conference (Presentations)
0940I001(S.Kadota), Y.Tezuka, S.Awale, JY.Ueda, J.Yin, T.Nobukawa: Investigation on the Chemical Constituents andBiological Activities of the Wood of Taxus Yunnanensis, an example of EBM to EBM, International Conference &Exhibition of the Modernization of Chinese Medicine & Health Products, (Hong Kong, '06.08).

0940I002

T.Nobukawa, O.Nakajima, M.Nobukawa, K.Kubo, T.Okano: The new herbal medicine: Taxus yunnanensis had
beneficial effects for interleukins of the Rheumatoid Arthritis, 1st Joint Meeting of European National Societies of
Immunology, (Paris, '06.09).

－ 130 －

0970

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Visiting Professor

SASAKI Kazuyuki

ｃataract，epidemiology，optics，ocular pharmacology，ocular
toxicology，uveitis，electromagnetic wave induced ocular tissuechanges

Professor(Additional Post)

SASAKI Hiroshi

Senior AssistantProfessor(Additional Post)

KOJIMA Masami

Researcher

YAMASHIRO Yoko

ｃataract，electromagnetic wave induced ocular tissue changes，
epidemiology

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
0970B001(T.Takata), T.Shimo-Oka, M.Kojima, K.Miki, N.Fujii: Differential analysis of D-β-Asp- containing proteins foundin normal and infrared irradiated rabbit lens, Biochem. Biophys. Res. Commun., 344:263-271, 2006.

0970B002(A.Arnarsson), T.Sverrisson, E.Stefansson, H.Sigurdsson, H.Sasaki, K.Sasaki, F.Jonasson: Risk factors for fiveyear incident age-related macular degeneration: The Reykjavik Eye Study, Am. J. Ophthalmol., 142:419-428,
2006.

0970B003(GM.Zoega), A.Fujisawa, H.Sasaki, A.Kubota, K.Sasaki, K.Kitagawa, F.Jonasson: Prevalence and risk factors forcornea guttata in the Reykjavik Eye Study, Ophthalmology, 113:565-569, 2006.

0970B004(A.Hirata), S.Watanabe, M.Kojima, I.Hata, K.Wake, M.Taki, K.Sasaki, O.Fujisawa, T.Shiozawa: Computationalverification of anesthesia effect on temperature variations in rabbit eyes exposed to 2.45 GHz microwave energy,
Bioelectromagnetics, 27:602-612, 2006.

0970B005(A.Hirata), S.Watanabe, O.Fujiwara, M.Kojima, K.Sasaki, T.Shiozawa: Temperature elevation in the eye ofJapanese male and female models for plane wave exposures, EMC, 17:29-32, 2006.
－ 131 －

0970B006(A.Hirata), S.Watanabe, M.Taki, O.Fujiwara, M.Kojima, K.Sasaki: Temperature elevation in rabbit eye irradiatedby 2.45-GHz exposure systems, IEICE, 50:29-34, 2006.

0970B008

M.Fukuda, H.Sasaki, Y.Ohashi: Intraocular penetration of moxifloxacin ophthlamic solution in rabbit eyes calculaation of maximum drug concentration in aqueous-, Journal of the eye., 23:1353-1357, 2006 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0970I001

K.Kitagawa, K.Hagihara, M.Fukuda, H.Sasaki, K.Shimoyama, K.Fujimoto, N.Ogawa, S.Sugai: Can lissamine green
replace rose bengal as the golden standard for Sjogren's syndrome diagnosis, IX International Symposium on
Sjogren's Syndrome, (Washington DC, '06.04).

0970I002

H.Sasaki, K.Nagai, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson, K.Sasaki: Cataract in diabetes ; The Reykjavik
Eye Study, The Association for Research in Vision and Ophthalmolpgy, (Florida, '06.05).

0970I003

H.Yaguchi, Y.Sakamoto, J.Qu, K.Nagai, M.Kojima, H.Sasaki, K.Sasaki: Localization of fiber folds in the crystalline
lens and influence on visual function, The Association for Research in Vision and Ophthalmology, (Florida, '06.05).

0970I004

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The Association
for Research in Vision and Ophthalmology, (Florida, '06.05).

0970I005

K.Sasaki, H.Sasaki, K.Nagai, H.Yaguchi, M.Kojima, Y.Sakamoto, R.Honda, F.Jonasson: Five-Year's lightscattering changes inlens layers in diabetics - The Reykjavik Eye Study -, The Association for Research in Vision
and Ophthalmology, (Florida, '06.05).

0970I006

M.Kojima, Y.Yamashiro, H.Sasaki, J.Qu, M.Hanazawa, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, K.Sasaki:
Investigation of safety exposure range by 60 GHz millimeter-wave for rabbit eyes, The Association for Research in
Vision and Ophthalmology, (Florida, '06.05).

0970I007

Y.Yamashiro, J.Qu, J.Tao, Y.Kawakami, M.Kojima, R.Honda, H.Sasaki, K.Sasaki: Characteristics of cataract ineyes with long axial length in a Chinese population, The Association for Research in Vision and Ophthalmology,(Florida, '06.05).

0970I008

H.Sasaki: Epidemiology Classification and diagnostic technique of cataract, The 6th Asian Cataract Research
Conference - Clinical Wokshop -, (Beijing, '06.06).

0970I009

J.Qu, H.Sasaki, Y.Sakamoto, M.Kojima, H.Yaguchi, Y.Yamashiro, R.Honda, K.Sasaki: Change in light scattering
intensity of crystalline lens over five years in the Japanese population - The Monzen Eye Study -, The 6th Asian
Cataract Research Conference, (Beijing, '06.06).

0970I010(J.Tao), J.Qu, R.Honda, M.Kojima, Q.Yan, J.Zhang, H.Sasaki, K.Sasaki: Prevalence of three main and six subtype
lens opacities in a rural Chinese population, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0970I011

K.Nagai, H.Sasaki, Y.Sakamoto, M.Kojima, K.Sasaki, F.Jonasson, R.Honda: Characteristics of lens opacity indiabetic patients - Reykjavik Eye Study -, The 6th Asian Cataract Research Conference, (Beijing, '06.06).

0970I012

M.Kojima, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, M.Hanazawa, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki:
Visualization of convective heat transportation of aqueous humor, The 6th Asian Cataract Research Congerence,(Beijing, '06.06).

0970I013(X.An), H.Sasaki, Y.Sakamoto, M.Kojima, Y.Kawakami, J.Tao, J.Qu, Z.Liu, J.Zhang, K.Sasaki: True exfoliation inchinese populationin a tropical area - The Senya Eye Study -, The 6th Asian Cataract Research Conference,(Beijing, '06.06).

0970I014

Y.Sakamoto, H.Nakaizumi, H.Sasaki, K.Sasaki: Higher order wavefront aberations with silicone asphric and acrylic
spherical intraocular lenses, The 6th Asian Cataract Research Conference, (Bijing, '06.06).

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0970I015

M.Kojima, Y.Susuki, Y.Yamashiro, M.Hanazawa, A.Hirata, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki: Assessment of
the thermal insult on aqueous humor convtion utilizing micro - capsulated thermo - chromic liquid crystal, The
Bioelectromagnetis Society the 28th Annual Meeting, (Cancun, '06.06).

0970I016

M.Kojima, Y.Suzuki, Y.Yamashiro, Y.Sakamoto, M.Hanazawa, S.Watanabe, M.Taki, H.Sasaki, K.Sasaki:
Investigation of convective heat transportation of aqueous humor during 60 GHz millimeter wave exposure, 4thInternational Workshop Biological Effects of Emfs, (Crete, '06.10).

0970I017

M.Kojima, Y.Suzuki, Y.Yamashiro, M.Hanazawa, S.Watanabe, M.Taki, Y.Sakamoto, H.Sasaki, K.Sasaki:
Relationship between the thermal insult by electromagneric wave exposure and convective heat transportation of
aqueous humor, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves, (Uchinada, '06.11).

0970I018

Y.Sakamoto, H.Sasaki, M.Kojima, M.Ono, K.Sasaki: Sun altitude and effective protection items against UV
exposure to the ocular surface - UV dosimetry by mannequin head, 2006 KMU Workshop on Ocular Changes
Induced by Electromagnetic Waves, (Uchinada, '06.11).

0970I019(Y.Suzuki), M.Kojima, Y.Yamashiro, K.Wake, M.Taki, M.Hanazawa, S.Watanabe: In-situ 3D temperature imaging
with micro - encapsulated thermo - chromic liquid crystal for electromagenetic field dosimetry, 2006 KMU
Workshop on Ocular Changes Induced by Electromagneric Waves, (Uchinada, '06.11).

0970I020

Y.Yamashiro, M.Kojima, Y.Sakamoto, H.Kawada, H.Sasaki, K.Sasaki: Suitable methodology to detection ocular
injury for millimater wave exposure, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves,(Uchinada, '06.11).

0970I021

H.Sasaki, R.Honda, M.Kojima, Y.Kawakami, Y.Sakamoto, J.Qu, K.Sasaki: High prevalence of pterygium in the
population of tropical area in China, 2006 KMU Workshop on Ocular Changes Induced by Electromagnetic Waves,(Uchinada, '06.11).

0970I022(H.Wakatsuchi), M.Hanazawa, T.Sakai, S.Watanabe, M.Kojima, Y.Yamashiro, K.Sasaki, O.Hashimoto: Complex
permittivities measurements of eye tissues in quasi - millimeter wave band, 2006 KMU Workshop on Ocular
Changes Induced by Electromagnetic Waves, (Uchinada, '06.11).

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