





 























  

 










































I
Code

Department

Basic

N
Page

Medicine

D

E

X

Code

Department

Page

0410

Department of Cardiovascular Surgery ･･････61

0100

Department of Anatomy Ⅰ･･････････････････1

0660

Department of Respirology (Thoracic Surgery)0110

Department of Anatomy Ⅱ･･････････････････20420

Department of Surgical Oncology ････････････64

0120

Department of Physiology Ⅰ ･･････････････････30430

Department of Orthopedics Surgery ･･･････････67･･････････････････50440

Department of Neurosurgery ･････････････････69

0140

Department of Biochemistry Ⅰ ･･･････････････70450

Department of Plastic and Reconstructive

0150

Department of Biochemistry Ⅱ･･････････････80160

Department of Pharmacology････････････････90460

Department of Pediatric Surgery ･･････････････73

0170

Department of Oncologic Pathology ･･････････110470

Department of Ophthalmology ････････････････75

0180

Department of Pathophysiological and

0480

Department of Otolaryngology ････････････････78

Experimental Pathology ････････････････････120490

Department of Dermatology ･･･････････････････80

0190

Department of Microbiology ･････････････････140500

Department of Urogenital Surgery ････････････82

0200

Department of Immunology ･･･････････････････160510

Department of Obstetrics and Gynecology ･････84

0210

Department of Medical Zoology ･･･････････････170520

Department of Anesthesiology and0220

Department of Pathology and Laboratory

0130 Department of Physiology Ⅱ･･62

Surgery ････････････････････････････････････71

Perioperative Medicine ･･････････････････････86

Medicine ･･･････････････････････････････････18

0650

Department of Rehabilitation Medicine ･･･････88

Department of Social and Environmental

0550

Department of Emergency Medicine････････････89

Medicine ･･･････････････････････････････････20

0570

District medical ･････････････････････････････90

0240 Department of Epidemiology and Public Health ･･･220530

Department of Oral and Maxillofacial Surgery･･91

0230

0250

Department of Legal Medicine ･･･････････････26

0260

Department of Medical Education ････････････27

Clinical Medicine

Schoolof

Nursing

8010

Basic Nursing

8030

Psychiatric and Mental Health Nursing ･･･････94･････････････････････････････93

0300

Department of Cardiovascular Medicine ･･･････29

8040

Adult Nursing

0310

Department of Respirolgy (Respiratory Medicine)･･31

8050

Nursing of the Elderly

0320

Department of Gastroenterology ･････････････33

8060

Child Nursing ･･････････････････････････････97

0330

Department of Nephrology ････････････････････37

8070

Maternity Nursing

0340

Department of Endocrinology and Metabolism･･･40

8080

Community Nursing･････････････････････99

0350

Department of Hematology and Immunology ･･･43

8090

Home Care Nursing･･･････････････････････100

0360

Department of Neurology ･････････････････････46

8100

Human Science････････････････････････101

0560

Department of Medical Oncology ･･････････････48

0565

Department of Infectious Diseases ･････････････51

0630

Department of General Internal Medicine ･･････52

0370

Department of Geriatric Medicine･･････････････53

0380

Department of Pediatrics ･････････････････････55

0390

Department of Neuropsychiatry ･･･････････････57

0400

Department of Diagnostic and Therapeutic
Radiology ･･･････････････････････････････････59････････････････････････････95･････････････････････････98

Liberal0040･･････････････････････96

Arts

Department of Life Science(Natural Science:Physics) ････････････････････105

0050

Department of Life Science(Natural Science:Chemistry)･･････････････････106

0060

Department of Life Science(Natural Science:Biology)･････････････････････107

CodeDepartment

Page

Code

0090 Department of Life Science (Physical Education)･･･1080010

Department of Human Science (Humanities) ･･･1090030

Department of Human Science (Mathematics) ･･110

0070

Department of Human Science(Foreign Languages:English)･･････････････････111

0080

Department of Human Science(Foreign Languages:German) ･････････････････112

0081

Department of Human Science (Linguistics) ･･･113

University

Hospital

0690

Department of Endoscopy ････････････････････115

0620

Department of Pathology･････････････････････116

0640

Endoscopy Center････････････････････････････118

0700

Multidiscciplinary Cancer Center ･････････････119

0670

Lifestyle-related Diseases Center ････････････122

0610

Health Management Center･････････････････123

0680

Medical Genetic Center ･･････････････････････126

MedicalResearch

Institute

0740

Division of Human Genetics (Biochemistry) ･･127

0750

Division of Human Genetics (Clinical Medicine) ･128

0770

Division of Core Facility (Radioisotope Center) ･･129

0780

Division of Core Facility(Experimental Animal Center) ･･････････････131

0800

Division of Core Facility(High-Tech Research Center) ･･･････････････132

0900

Division of Cell Medicine ･･･････････････････135

0910

Division of Advanced Medicine ･･････････････136

0920

Division of Molecular Oncology and Virology ････138

0930

Division of Dermatomycology(Novartis Pharma) ･････････････････････････141

0970

Division of Vision Research forEnvironmental Health ･･････････････････････143

AffiliatedInstitution

9050

Center for FDD-MB･･････････････････････････147

9030

North Noto Institute of Community Medicine ･･･148

Department

Himi
9100

Municipal

Page

Hospital

Himi Municipal Hospital･････････････････････149

Basic Medicine

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience.

Associate Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology.

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical.

Senior Assistant Professor

SIMAMURA Eriko

Medical science of free radical.

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001(M.Yamada), J.Udagawa, A.Matsumoto, R.Hashimoto, T.Hatta, M.Nishita, Y.Minami, H.Otani: Ror2 is required for
midgut elongation during mouse development, Dev. Dyn., 239:941-953, 2010.

0100B002

E.Simamura, H.Shimada, N.Higashi, M.Uchishiba, H.Otani, T.Hatta: Maternal leukemia inhibitory factor (LIF)
promotes fetal neurogenesis via a LIF-ACTH-LIF signaling relay pathway, Endocrinology, 151:1853-1862, 2010.

Reviews
0100C001(H.Otani), J.Udagawa, T.Hatta, Y.Kagohashi, R.Hashimoto, A.Matsumoto, F.Satow, M.Nimura: Individual variationin organ histogenesis as a causative factor in the developmental origins of health and disease: unnoticed congenital
anomalies?, Congenit. Anom. (Kyoto), 50:205-211, 2010.

Presentations at Conference
International Conference (Presentations)
0100I001

T.Hatta, H.Shimada, E.Simamura, Y.Ishigaki, N.Higashi, T.Tatsuno, F.Takano: Alteratio of gene expression
profiles in the fetal cerebrum after injection of leukemia inhibitory factor into dams, Society for NEUROSCIENCE
2010, (San Diego, '10.11).

－ 1 －

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHINOHARA
Harumichi

gross anatomy, embryology, lymphatic vessels, microscopy.

Associate Professor

SHIMOKAWA Takashi regeneration of skeletal muscle,development of peripheral nerve.

Senior Assistant Professor

YASUTAKA Satoru

gross anatomy, central nervous system.

Senior Assistant Professor

KOMINAMI Rieko

immunocytochemistry, pituitary, cell proliferation, electron
microscopy.

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA

Outline of Research
Theme of researches
1）Anatomical study of brain white matter by using fiber dissection technique2）Immuno-histochemical study of pituitary gland3）Tissue regeneration in urodele amphibian

－ 2 －

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science.

Associate Professor

SUGAI Tokio

Neurophysiology.

Assistant Professor

YAMAMOTO Ryo

Neuroscience.

Research Associate

ADACHI Hiroshi

Neuroscience.

Researcher(Additional Post) WANG Furong
Researcher(Additional Post) SUN Peng

Analysis of Alzheimer disease model mice in search for new
therapeutic approaches.
Analysis of mood disorder model mice in search for new therapeutic
approaches.

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, optical imaging, optical recording,olfactory system, olfactory center, chemical sense, vomeronasal organ, vomeronasal nerve, vomeronasal nerve layer, main
olfactory bulb, accessory olfactory bulb, piriform cortex, field potential, propagating signal, horizontal propagation,
oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision, intracellular recording,intracellular staining, GABA, GABAA receptor, GABAB receptor

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released
or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron
excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellularmessenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic
efficiency and neuron excitability. As another research topic, we are also studying feature detection mechanisms inpheromone-based olfactory sensation by using in vivo preparation.

Publications
Originals
0120B001

H.Yoshimura, T.Sugai, M.Honjo, K.Kaneyama, N.Segami, N.Kato: Application of caffeine reveals input frequencydependent determination of signal-traveling routes between primary and secondary visual cortices in rats,
Neurosci. Res., 66:30-36, 2010.

0120B002

H.Yoshimura, S.Morimoto, M.Okuro, N.Segami, N.Kato: Evaluations of dementia by EEG frequency analysis andpsychological examination, J. Physiol. Sci., 60:383-388, 2010.

－ 3 －Presentations at Conference
International Conference (Presentations)
0120I001

N.Kato, P.Sun, Y.Zhang, F-R.Wang, L.Wang, R.Yamamoto, T.Sugai, Z-D.Wang, R.Chen: Increased excitability of
cingulate cortex neurons in a mouse model of depression, Cold Spring Harbor Asia Conference1st Francis Crick
Neuroscience Symposium, (Suzhou, '10.04).

0120I002

N.Kato, F.Wang, Y.Zhang, L.Wang, P.Sun, R.Yamamoto, T.Sugai, Z.Wang: Improved learning parallels
normalization of electrophysiological properties after transcranial magnetic stimulation in a mouse alzheimer's
disease model, Neuroscience 2010, (San Diego, '10.11).

－ 4 －

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology.

Associate Professor

KURATA Yasutaka

Cardiac Electrophysiology.

Senior Assistant Professor

MIYAMAE Shunichi

Cardiac Electrophysiology.

Researcher

OMUKAI Chieko

Circulatory Physiology.

Researcher

KUDA Yuichi

Circulatory Physiology.

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

H.Takano, T.Shibamoto, W.Zhang, Y.Kurata: Liver volume, as assessed by four ultrasonic crystals arranged toform a tetrahedron, decreases during anaphylactic shock in anesthetized rats, Shock, 34:586-591, 2010.

0130B002

S.Cui, T.Shibamoto, W.Zhang, Y.Kurata, O.Kashimura, S.Miyamae: Exercise training attenuates anaphylactic
venoconstriction in rat perfused liver, but does not affect anaphylactic hypotension in conscious rats, Clin. Exp.
Pharmacol. Physiol., 37:889-893, 2010.

0130B003(K.Morikawa), U.Bahrudin, J.Miake, O.Igawa, Y.Kurata, Y.Nakayama, Y.Shirayoshi, I.Hisatome: Identification,
isolation and characterization of HCN4-positive pacemaking cells derived from murine embryonic stem cells during
cardiac differentiation, Pacing Clin. Electrophysiol., 33:290-303, 2010.

0130B004

Y.Kurata, H.Matsuda, I.Hisatome, T.Shibamoto: Roles of hyperpolarization-activated current If in sinoatrial node
pacemaking: insights from bifurcation analysis of mathematical models, Am. J. Physiol. Heart Circ. Physiol.,
298:H1748-H1760, 2010.

－ 5 －Presentations at Conference
International Conference (Presentations)
0130I001

T.Shibamoto, W.Zhang, Y.Kurata, S.Miyamae: Effect of exercise training on anaphylaxis in perfused rat liver andin conscious rat, Experimental Biology2010, (Anaheim, '10.04).

0130I002

T.Shibamoto, W.Zhang, C.Ohmukai, Y.Kuda, Y.Kurata: Mesenteric lymph flow increases during anaphylactic
hypotension in anesthetized rats, The 6th International Congress of Pathophysiology, (Montreal, '10.09).

－ 6 －

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins.

Faculty

Professor

DATE Takayasu

Function of protein Kinase, PKU-β/TLK1 and PKU-α/TLK2.

Senior Assistant Professor

HASHIMOTO
Mitsumasa

Cell biology, DNA repair, Cell cycle, p53-binding proteins.

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins.

Assistant Professor

HASHIMOTO Yumi

Molecular biology, DNA repair, p53-binding proteins.

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

－ 7 －

0150

Department of Biochemistry Ⅱ

Name

Field of Specialization

Faculty
Title
Professor

Molecular mechanisms of angiogenesis, Alternative mRNA processing,MicroRNA function.
MicroRNA involved in angiogenesis, Functions of FGF-2 binding
YOSHITAKE Yoshino
protein.
YONEKURA Hideto

Associate Professor
Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing.

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001(K.Ohe), T.Watanabe, S.Harada, S.Munesue, Y.Yamamoto, H.Yonekura, H.Yamamoto: Regulation of alternative
splicing of the receptor for advanced glycation endproducts (RAGE) through G-rich cis-elements and heterogenous
nuclear ribonucleoprotein H, J. Biochem., 147:651-659, 2010.

0150B002(S.Takasawa), M.Kuroki, K.Nata, N.Noguchi, T.Ikeda, A.Yamauchi, H.Ota, A.Itaya-Hironaka, S.SakuramotoTsuchida, I.Takahashi, T.Yoshikawa, T.Shimosegawa, H.Okamoto: A novel ryanodine receptor expressed inpancreatic islets by alternative splicing from type 2 ryanodine receptor gene, Biochem. Biophys. Res. Commun.,
397:140-145, 2010.

0150B003

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

－ 8 －

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor(Additional Post)

ISHIBASHI Takaharu

Senior Assistant Professor

YOSHIDA Junko

Researcher

ABE Fusae

Researcher

LIU HeField of Specialization
Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs.
Kinetics of NO(nitric oxide)-related compounds in cardiovascularsystem.
Pharmacology in cardiovascular system, Cancer chemotherapy.
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy.
Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer Chemotherapy.

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, intracellular Ca2+, coronary circulation,
nitric oxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug,
proliferation, cell biology

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system

Publications
Originals
0160B001

J.Yoshida, T.Ishibashi, M.Yang, M.Nishio: Amlodipine, a Ca2+ channel blocker, suppresses phosphorylation of
epidermal growth factor receptor in human epidermoid carcinoma A431 cells, Life Sci., 86:124-132, 2010.

0160B002(K.Ozaki), T.Hori, T.Ishibashi, M.Nishio, Y.Aizawa: Effects of chronic cigarette smoking on endothelial function inyoung men, J. Cardiol., 56:307-313, 2010.

Presentations at Conference
International Conference (Synposium)
0160H001

T.Ishibashi: Fundamental characteristics of nitrite in biological systems, The International Symposium on Food,
Nutrition and Vascular function, (Tokushima, '10.02).

－ 9 －International Conference (Presentations)
0160I001

T.Ishibashi, N.Nishizawa, M.Nakamoto, J.Yoshida, M.Nishio: Arterio-venous difference in plasma nitrite
concentration is not indicated at steady-state in anesthetized animals, The 6th International Conference on the
Biology, Chemistry, and Therapeutic Applications of Nitric Oxide, (Kyoto, '10.06)，Nitric Oxide, 22(Suppl.):S13S14, 2010.

－ 10 －

0170

Department of Oncologic Pathology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOHNO Hiroyuki

Experimental pathology, Tumor immunology.

Assistant Professor

OYAMA Takeru

Mechanisms of carcinogenesis.

Keywords of Research
cancer chemoprevention, antioxidant, flavonoid, carotenoid, COX-2 inhibitor, organoselenium, intercelluar communication,intermediate biomarker, detoxification enzyme, PCNA, BrdU, apoptosis, cytology, hepatocellular carcinoma, Min mice,inflammation

Outline of Research
Cancer is the result of abnormal genetic control of cell growth that arises from structural alterations in DNA or mutations.
Many mutations occur in somatic cells during the lifetime of an individual and some may result in cancer. There is evidence
that dietary factors can impede this process. For example, epidemiological studies reveal that the quarter of the population
with the lowest dietary intake of fruits and vegetables has roughly twice the cancer risk for most types of cancer comparedwith the quarter with the highest intake. In recent years the possible chemoprevention of cancer by specific chemical
constituents of fruits and vegetables has attracted much attention. Also, several drugs, i.e., COX-2 inhibitors and iNOS
inhibitors have been found to effectively inhibit cancer development in animal carcinogenesis models and human clinicalstudies. Our mission of The Department of Oncologic Pathology is to advance the science and application of cancer
prevention through multidisciplinary strategies in research, clinical service, and education using novel animal models andimaging system.

Publications
Originals
0170B001

M.Matoba, T.Kondo, T.Tanaka, M.Kitadate, K.Oota, H.Tonami: Noninvasive monitoring of radiation-induced early
therapeutic response using high-resolution MR imaging and proton MR spectroscopy in VX2 carcinoma, J. Radiat.
Res., 51:699-705, 2010.

0170B002

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

－ 11 －

0180

Department of Pathophysiological and Experimental Pathology

Faculty
Title

Name

Field of Specialization

Professor

KATSUDA Shogo

Vascular pathology, Pathophysiology of ECM.

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology.

Associate Professor

SATO Katsuaki

Neuropathology.

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer.

Researcher

TANG Lihua

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB

Outline of Research
1. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.
2. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
3. To elucidate mechanisms of neuronal injury by amyloid β protein, presumed to have essential role on Alzheimer's
disease, we identify amyloid β protein-binding proteins in neuron by proteome analysis and explore functional disturbancesof these proteins.

Publications
Originals
0180B001

L.Zhang, K.Higashi, Y.Ishigaki, Y.Ueda, T.Sakuma, T.Takegami, M.Oguchi, K.Xu, Y.Ohta, H.Nishida, H.Tonami:
Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as
biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma, Ann. Nucl.
Med., 24:533-540, 2010.

0180B002

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, Xi.Zhao, Y.Ueda, K.Higashi, T.Sakuma:
Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission
tomography in lung cancer, Gen. Thorac. Cardiovasc. Surg., 58:405-410, 2010.

0180B003

T.Mikami, T.Ichiseki, A.Kaneuji, Y.Ueda, T.Sugimori, K.Fukui, T.Matsumoto: Prevention of steroid-induced
osteonecrosis by intravenous administration of vitamin E in a rabbit model, J. Orthop. Sci., 15:674-677, 2010.

Reviews
0180C002

Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami,
S.Katsuda: Aquaporin as a novel player in cancer cell the invasion of cancer cells, J. Kanazawa. Med. Univ.,
35:55-60, 2010 (in Japanese) .

－ 12 －

Case Reports
0180D001(K.Oe), T.Araki, H.Ogawa, A.Nakashima, K.Sato: Fatal cytomegalovirus infection with CD4+ T-lymphocytopenia
during corticosteroid therapy for bronchial asthma, J. Infect. Chemother., 16:131-134, 2010.

0180D002

K.Sato, T.Imai, Y.Shirota, Y.Ueda, S.Katsuda: Combined large cell neuroendocrine carcinoma and adenocarcinomaof the gallbladder, Pathol. Res. Pract., 206:397-400, 2010.

0180D003(K.Oe), T.Araki, A.Nakashima, K.Sato, T.Konno, M.Yamagishi: Late onset of cholesterol crystal embolism after
thrombolysis for cerebral infarction, Intern. Med., 49:833-836, 2010.

0180D004

K.Sato, K.Terai, M.Ozaki, Y.Ueda, S.Katsuda: Odontogenic myxofibroma with HMGA2 overexpression and

HMGA2 rearrangement, Pathol. Int., 60:760-764, 2010.

Presentations at Conference
International Conference (Presentations)
0180I001

Y.Machida, Y.Ueda, M.Shimasaki, M.Sato, M.Sagawa, S.Katsuda, T.Sakuma: Relationship of auaporin 1,3 and 5
expression levels in non-neoplastic lung tissue to cellular differentiation, invasive growth and metastasis potential.,
ATS 2010 International canference, (New Orleans, '10.05).

－ 13 －

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Professor

OHARA Yoshiro

Neurovirology, Neuroimmunology.

Associate Professor

MURAKI Yasushi

Virology.

Assistant Professor

HIMEDA Toshiki

Neurovirology.

Assistant Professor

OKUWA Takako

Virology.

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis

Outline of ResearchStudies on pathomechanism of virus induced demyelination

Publications
Originals
0190B001

K.Ichinose-Asakura, N.Taniura, T.Himeda, M.Nojiri, T.Okuwa, Y.Ohara: Leader(L) of Theiler's murine
encephalomyelitis virus (TMEV) is required for virus growth in a murine macrophage-like cell line, Virus Res.,
147:224-230, 2010.

0190B002

T.Himeda, T.Okuwa, Y.Muraki, Y.Ohara: Cytokine/chemokine profile in J774 macrophage cells persistently
infected with DA strain of Theiler's murine encephalomyelitis virus (TMEV), J. Neurovirol., 16: 219-229, 2010.

0190B003

T.Okuwa, N.Taniura, M.Saito, T.Himeda, Y.Ohara: Opposite effects of two nonstructural proteins of Theiler’s
murine encephalomyelitis virus regulates apoptotic cell death in BHK-21 cells, Microbiol. Immunol., 54:639-643,
2010.

0190B004

K.Saito, M.Saito, N.Taniura, T.Okuwa, Y.Ohara: Activation of the PI3K-Akt pathway by human T cell leukemia
virus type 1 (HTLV-1) oncoprotein Tax increases Bcl3 expression, which is associated with enhanced growth of
HTLV-1-infected T cells, Virology, 403:173-180, 2010.

Others
0190F004

Y.Ohara, T.Okuwa, T.Himeda: The role of nonstructural proteins of Theiler's murine encephalomyelitis virus, L
and L*, in virus demyelination, Report of Lactobacillus Meeting 2009, 200-202, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0190I001

Y.Muraki, T.Okuwa, T.Furukawa, Y.Matsuzaki, K.Sugawara, T.Himeda, S.Hongo, Y.Ohara: Role of palmitoylationof CM2 in the influenza C virus replication, Options for the control of influenza VII, (Hong Kong, '10.09).

0190I002

T.Himeda, M.Nojiri, T.Okuwa, Y.Muraki, Y.Ohara: Mitochondrial targeting of anti-apoptotic protein L* of
Theiler’s murine encephalomyelitis virus (TMEV), Europic 2010, (St. Andrews, '10.09).

－ 14 －

0190I003

Y.Ohara, T.Himeda, T.Okuwa, Y.Muraki: The profile of cytokine expression involved with virus persistence andvirus-induced demyelination, 10th International Congress of Neuroimmunology, (Barcelona, '10.10).

－ 15 －

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology.

Associate Professor

SHIMIZU Shoji

Immunology, Protective immunology, Tumor immunology.

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology.

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

Publications
Originals
0200B001

M.Sakuma, S.Matsuba, H.Matsuno, K.Uchikawa, T.Itou, S.Shimizu, N.Yamaguchi: Effect of hot-springhydrotherapy on lymphocyte subsets expressing β２-adrenergic receptors, The Journal of the Japanese Society ofBalneology, 73:101-108, 2010 (in Japanese) .

0200B002

M.Sakuma, M.Arai, S.Matsuba, N.Yamaguchi: Effects of acupuncture on intracellular cytokine and hormone levels
in human peripheral blood, Cytometry Res., 20:41-48, 2010 (in Japanese) .

－ 16 －

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease.

Senior Assistant Professor

ICHIKAWA Hidetaka Immunological study for parasitic diseases.

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.2.Epidemiological research of tickborn diseases in the Noto Peninsula,Ishikawa Prefect.

Publications
Originals
0210B001

Y.Oikawa, A.Kobayashi, K.kitagawa: Anti-acanthamoeba efficacy in pimaricine (natamycin) whici is antimycotic
drug, Ann. rep. Ohara Hosp., 50：27-30, 2010 (in Japanese) .

－ 17 －

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology.

Assistant Professor

KINOSHITA Erikosurgical pathology, molecular pathology.

Assistant Professor

NAKADA Satoko

surgical pathology.

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors.
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura.

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, "lung, mediastinum, and pleura", head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Publications
Originals
0220B001(Y.Nakanuma), Y.Zen, K.Harada, M.Sasaki, A.Nonomura, T.Uehara, K.Sano, F.Kondo, T.Fukusato, K.Tsuneyama,
M.Ito, K.Wakasa, M.Nomoto, H.Minato, H.Haga, M.Kage, H.Yano, J.Haratake, S.Aishima, T.Masuda, H.Aoyama,
A.Miyakawa-Hayashino, T.Matsumoto, H.Sanefuji, H.Ojima, T-C.Chen, E.Yu, J-H.Kim, YN.Park, W.Tsui:
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens:
interobserver agreement, Pathol. Int., 60:167-174, 2010.

0220B002

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

Case Reports
0220D001(J.Shimizu), Y.Arano, N.Ishikawa, M.Oda, I.Matsumoto, H.Minato: Clinicopathological study of surgically treatedcases of tracheobronchial adenoid cystic carcinoma, Gen. Thorac. Cardiovasc. Surg., 58:82-86, 2010.

0220D002(J.Shimizu), C.Ikeda, Y.Arano, I.Adachi, M.Morishita, S.Yamaguchi, N.Ishikawa, G.Watanabe, H.Minato: Advanced
lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection undercardiopulmonary bypass, Ann Thorac Cardiovasc Surg, 16:286-290, 2010.

－ 18 －

0220D003

H.Minato, S.Kaji, E.Kinoshita, N.Kurose, T.Nojima, M.Kohno, K.Konuma, H.Ikawa: Solitary intrapulmonary cystic
lymphangioma in an infant: A case report with literature review, Pathol. Res. Pract., 206:851-856, 2010.

0220D004(S.Miwa), S.Kitamura, T.Shirai, K.Hayashi, H.Nishida, A.Takeuchi, T.Nojima, H.Tsuchiya: Desmoplastic smallround cell tumour successfully treated with caffeine-assisted chemotherapy: a case report and review of theliterature, Anticancer Res., 30:3769-3774, 2010.

0220D005(J.Shimizu), Y.Arano, I.Adachi, M.Morishita, B.Fuwa, S.Yokokawa, S.Minami, M.Hiroshi: Adenosquamous
carcinoma of the lung in a patient with complete situs inversus, Medical journal of Mutual Aid Association, 59:1822, 2010 (in Japanese) .

0220D006

M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: Primary neurolymphomatosis of the cervical nerve root,
The Japanese Journal of Clinical Hematology, 51:564-567, 2010 (in Japanese) .

0220D007

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy, 37:1341-1344, 2010 (in Japanese) .

Others
0220F001(J.Shimizu), Y.Arano, C.Ikeda, I.Adachi, N.Ishikawa, Y.Hirano, H.Minato: Modification of the surgical procedure toenable the complete resection of lung cancer with carcinomatous pleuritis, Surg Today, 40:890-893, 2010.

－ 19 －

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor

YAMADA Yuichi

Occupational Health, Epidemiology of circulatory and respiratory
diseases.

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stress.

Associate
Professor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry.

Senior Assistant Professor

NAKATA Minori

Industrial hygiene, Occupational medicine, Musculoskeletal disorders.

Senior Assistant Professor

NOBORISAKA Yuka

Occupational Health, Job stress.

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: Bone resorption
acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure, Toxicol. Mech.
Methods., 20:7-13, 2010.

0230B002

Q.LI, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa:Occupational class and incidence rates of cardiovascular events in middle aged men in Japan, Ind. Health, 48:324330, 2010.

0230B003

M.Nakashima, M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, J. Atheroscler. Thromb., 17:1082-1095, 2010.

0230B004

W.Hirokawa, K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middleaged Japanese men, J. Atheroscler. Thromb., 17:934-943, 2010.

0230B005

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse, H.Nakagawa:Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged nondiabetic Japanese men, Diabetologia, 53:1894-1902, 2010.

0230B006

R.Honda, W.Swaddiwudhipong, M.Nishijo, P.Mahasakpan, W.Teeyakasem, W.Ruangyuttikarn, S.Satarug,
C.Padungtod, H.Nakagawa: Cadmium induced renal dysfunction among residents of rice farming area downstream
from a zinc-mineralized belt in Thailand, Toxicol. Lett., 198:26-32, 2010.

－ 20 －

0230B007(A.Inoue), N.Kawakami, M.Ishizaki, A.Shimazu, M.Tsuchiya, M.Tabata, M.Akiyama, A.Kitazume, M.Kuroda:
Organizational justice, psychological distress, and work engagement in Japanese workers, Int. Arch. Occup.
Environ. Health., 83:29-38, 2010.

0230B008(N.Kalezic), Y.Noborisaka, M.Nakata, A.G.Crenshaw, S.Karlsson, E.Lyskov, P.O.Eriksson: Cardiovascular andmuscle activity during chewing in whiplash-associated disorders (WAD), Arch. Oral Biol., 55:447-453, 2010.

0230B009(R.Sato), T.Kido, R.Honda, M.Nishijo, H.Nakagawa, E.Kobayashi, Y.Suwazono: Seventeen-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan, Bull. Environ.
Contam. Toxicol., 84:363-367, 2010.

0230B010(I.Ishikawa), S.Hayama, K.Morita, T.Nakazawa, H.Yokoyama, R.Honda, K.Satoh, T.Kakuma: Long-term natural
history of acquired cystic disease of the kidney, Ther Apher Dial, 14:409-416, 2010.

0230B011(A.Inoue), N.Kawakami, T.Haratani, F.Kobayashi, M.Ishizaki, T.Hayashi, O.Fujita, Y.Aizawa, S.Miyazaki, H.Hiro,
T.Masumoto, S.Hashimoto, S.Araki: Job stressors and long-term sick leave due to depressive disorders among
Japanese male employees:findings from the Japan work stress and health cohort study, J. Epidemiol. Community
Health., 64:229-235, 2010.

0230B012(W.Swaddiwudhipong), P.Limpatanachote, M.Nishijo, R.Honda, P.Mahasakpan, S.Krintratun: Cadmium-exposed
population in Mae Sot district, Tak province:3. associations between urinary cadmium and renal
dysfunction,hypertension,diabetes, and urinary stones, J. Med. Assoc. Thai., 93:231-238, 2010.

0230B013(P.Limpatanachote), W.Swaddiwudhipong, M.Nishijo, R.Honda, P.Mahasakpan, K.Nambunmee, W.Ruangyuttikarn:
Cadmium-exposed population in Mae Sot district, Tak province: 4 bone mineral density in persons with highcadmium exposure, J. Med. Assoc. Thai., 93:1451-1457, 2010.

Presentations at Conference
International Conference (Presentations)
0230I001

M.Ishizaki, H.Nakagawa, N.Kawakami, A.Inoue, Y.Morikawa, T.Kido, Y.Yamada: Relationship between job stressand job performance in a factory, The Joint Scientific Meeting of International Epidemiological Association Western
Pacific Region and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of
Epidemiology, 20(Suppl 1):295, 2010.

0230I002

K.Nakamura, W.Hirokawa, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormality and risk of cardiovascular diseases among middle-aged Japanese men,
The Joint Scientific Meeting of International Epidemiological Association Western Pacific Region and 20th Japan
Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology, 20(Suppl 1):191, 2010.

0230I003

M.Sakurai, M.Nakashima, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, The Joint Scientific Meeting of International Epidemiological Association Western PacificRegion and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology,20(Suppl 1):216, 2010.

0230I004

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse: Association between
long working hours and sleep problems in white-collar workers, The Joint Scientific Meeting of International
Epidemiological Association Western Pacific Region and 20th Japan Epidemiological Association, (Koshigaya,'10.01).

0230I005

M.Nakata, M.Yoshizawa, Y.Yamada, K.Kagechika,, P.O.Eriksson: Pressure pain thresholds at different body
regions in chronic musculoskeletal disorders(MSD) vs healthy, Seventh International Conference on Prevention ofWork-Related Musculoskeletal Disorders, (Angers, '10.08).

0230I006

M.Nishijo, W.Swaddiwudhipong, K.Nambunmee, W.Ruangyuttikam, R.Honda, Y.Morikawa, H.Nakagawa: Effect of
cadmium on health risk of arterioselerosis; a study of Thai population environmentary exposed to cadmium, 6thconference on molecular mechanisums of metal toxicity and carcinogenesis, (Kentucky, '10.11).

－ 21 －

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine.

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine.

Associate Professor

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution.

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology.

NAKAMURA Koshi

Epidemiology of Cardiovascualr disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure.

NAKANISHI Yumiko

Preventive medicine.

Associate
Professor(Additional Post)
Senior AssistantProfessor(Additional Post)

Keywords of Research
epidemiology, public health, hypertension, diabetes mellitus, shift work, nutrition, calcium, stress, smoking, insulin
resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractable disease,cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid peroxide,
community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases(mainly of Cardiovascular Diseases)
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: Bone resorption
acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure, Toxicol. Mech.
Methods., 20:7-13, 2010.

0240B002(The Emerging Risk Factors Collaboration), H.Nakagawa, Collabrators(273): C-reactive protein concentration andrisk of coronary heart disease,stroke, and mortality:an individual participant meta-analysis, Lancet, 375:132-140,
2010.

0240B003(K.Miura), N.Okuda, T.C.Turin, N.Takashima, H.Nakagawa, K.Nakamura, K.Yoshita, A.Okayama, H.Ueshima,
NIPPON DATA80/90 Research Group: Dietary salt intake and blood pressure in a representative Japanese
population: baseline analyses of NIPPON DATA80, J Epidemiol, 20(Suppl):S524-S530, 2010.

0240B004(N.Okuda), K.Miura, K.Yoshita, Y.Matsumura, A.Okayama, Y.Nakamura, T.Okamura, S.Saitoh, K.Sakata,
T.Ojima, TC.Turin, H.Ueshima, H.Nakagawa, NIPPON DATA80/90 Research Group: Integration of data fromNIPPON DATA80/90 and National Nutrition Survey in Japan: for cohort studies of representative Japanese on
nutrition, J Epidemiol, 20(Suppl):S506-S514, 2010.

－ 22 －

0240B005

Q.LI, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa:Occupational class and incidence rates of cardiovascular events in middle aged men in Japan, Ind. Health, 48:324330, 2010.

0240B006

M.Nakashima, M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, J. Atheroscler. Thromb., 17:1082-1095, 2010.

0240B007(N.Takashima), K.Miura, A.Hozawa, A.Kadota, T.Okamura, Y.Nakamura, T.Hayakawa, N.Okuda, A.Fujiyoshi,
SY.Nagasawa, T.Kadowaki, Y.Murakami, Y.Kita, A.Okayama, H.Ueshima, H.Nakagawa, NIPPON DATA 90
Research Group, Collaborator(19): Population attributable fraction of smoking and metabolic syndrome on
cardiovascular disease mortality in Japan: a 15-year follow up of NIPPON DATA90, BMC Public Health, 10:306,
2010.

0240B008(U.Tamura), T.Tanaka, T.Okamura, T.Kadowaki, H.Yamato, H.Tanaka, M.Nakamura, A.Okayama, H.Ueshima,
Z.Yamagata, HIPOP-OHP research group, H.Nakagawa: Changes in weight, cardiovascular risk factors andestimated risk of coronary heart disease following smoking cessation in Japanese male workers:HIPOP-OHP study,
J. Atheroscler. Thromb., 17:12-20, 2010.

0240B009

W.Hirokawa, K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middleaged Japanese men, J. Atheroscler. Thromb., 17:934-943, 2010.

0240B010(Z.Guo), K.Miura, TC.Turin, A.Hozawa, N.Okuda, T.Okamura, S.Saitoh, K.Sakata, H.Nakagawa, A.Okayama,
K.Yoshita, T.Kadowaki, S.R Choudhury, Y.Nakamura, B.L Rodriguez, JD.Curb, P.Elliott, J.Stamlar, H.Ueshima:
Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic
syndrome in Japanese:the INTERLIPID study, J. Atheroscler. Thromb., 17：777-784, 2010.

0240B011(S.Katano), Y.Nakamura, A.Nakamura, Y.Murakami, T.Tanaka, H.Nakagawa, T.Takebayashi, H.Yamato,
A.Okayama, K.Miura, T.Okamura, H.Ueshima, HIPOP-OHP Research Group: Relationship among physicalactivity,smoking,drinking and clustering of the metabolic syndrome diagnostic components, J. Atheroscler.
Thromb., 30:644-50, 2010.

0240B012

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse, H.Nakagawa:Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged nondiabetic Japanese men, Diabetologia, 53:1894-1902, 2010.

0240B013

R.Honda, W.Swaddiwudhipong, M.Nishijo, P.Mahasakpan, W.Teeyakasem, W.Ruangyuttikarn, S.Satarug,
C.Padungtod, H.Nakagawa: Cadmium induced renal dysfunction among residents of rice farming area downstream
from a zinc-mineralized belt in Thailand, Toxicol. Lett., 198:26-32, 2010.

0240B014(R.Oka), J.Kobayashi, A.Inazu, K.Yagi, S.Miyamoto, M.Sakurai, K.Nakamura, K.Miura, H.Nakagawa, M.Yamagishi:
Contribution of visceral adiposity and insulin resistance to metabolic risk factors in Japanese men, Metabolism,
59:748-754, 2010.

0240B015(H.Yatuya), H.Toyoshima, K.Yamagishi, K.Tamakoshi, M.Taguri, A.Harada, Y.Ohashi, Y.Kita, Y.Naito, M.Yamada,
N.Tanabe, H.Iso, H.Ueshima, H.Nakagawa, Japan Arteriosclerosis Longitudinal Study (JALS) group: Body massindex and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanesecohorts using individual data, Circ. Cardiovasc. Qual. Outcomes., 3:498-505, 2010.

0240B016(D.D.Nhu), T.Kido, R.Naganuma, H.Suzuki, N.Kuroda, S.Honma, P.T.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
N.N.Hung, L.T.H.Thom, L.K.Son: Salivary cortisol and cortisone levels,and breast milk dioxin concentrations in
Vietnamese primiparas, Toxicol. Environ. Chem., 92:1939-1952, 2010.

0240B017

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology, 24:8-13, 2010.

0240B018(R.Sato), T.Kido, R.Honda, M.Nishijo, H.Nakagawa, E.Kobayashi, Y.Suwazono: Seventeen-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan, Bull. Environ.
Contam. Toxicol., 84:363-367, 2010.

－ 23 －

0240B019(W.Swaddiwudhipong), P.Limpatanachote, M.Nishijo, R.Honda, P.Mahasakpan, S.Krintratun: Cadmium-exposed
population in Mae Sot district, Tak province:3. associations between urinary cadmium and renal
dysfunction,hypertension,diabetes, and urinary stones, J. Med. Assoc. Thai., 93:231-238, 2010.

0240B020(P.Limpatanachote), W.Swaddiwudhipong, M.Nishijo, R.Honda, P.Mahasakpan, K.Nambunmee, W.Ruangyuttikarn:
Cadmium-exposed population in Mae Sot district, Tak province: 4 bone mineral density in persons with highcadmium exposure, J. Med. Assoc. Thai., 93:1451-1457, 2010.

0240B021(R.Oka), K.Miura, M.Sakurai, K.Nakamura, K.Yagi, S.Miyamoto, T.Moriuchi, H.Mabuchi, J.Koizumi, H.Nomura,
Y.Takeda, A.Inazu, A.Nohara, MA.Kawashiri, S.Nagasawa, J.Kobayashi, M.Yamagishi: Impacts of visceral adipose
tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese, Obesity, 18:153-60,
2010.

0240B022

K.Nakamura, T.Okamura, T.Hayakawa, H.Kanda, A.Okayama, H.Ueshima, Health Promotion Research Committeeof the Shiga National Health Insurance Organizations: Medical expenditures of men with hypertension and/or asmoking habit: a 10-year follow-up study of national health insurance in Shiga, Japan, Hypertens. Res., 33:802807, 2010.

Reviews
0240C001(R.Huxley), K.Nakamura, M.Woodward: Modification of the effect of lipids on the risk of cardiovascular diseases bycigarette smoking, Clin. Lipidol., 5:413-420, 2010.

0240C004

K.Nakamura, H.Nakagawa: Prevention of stroke, Journal of Medical Technology, 54:1487-1493, 2010 (inJapanese) .

0240C005

K.Nakamura: Impacts of cardiovascular risk factors on medical expenditures, Hokuriku Japanese Journal of Public
Health, 37:1-6, 2010 (in Japanese) .

Short Communications
0240E001(E.Hamaguchi), T.Takamura, M.Sakurai, E.Mizukoshi, Y.Zen, Y.Takeshita, S.Kurita, K.Arai, T.Yamashita,
M.Sasaki, Y.Nakanuma, S.Kaneko, The histological course of nonalcoholic fatty liver disease in Japanese patients:
Tight glycemic control, rather than weight reduction, ameliorates liver fibrosis, Diabetes Care., 33:284-286, 2010.

Others
0240F014

M.Sakurai, T.Takamura, K.Miura, S.Kaneko, H.Nakagawa: J-shaped relationship between anthropometric indicesand risk for diabetes in relatively lean Japanese, Journal of Metabolic Syndrome, 6:36-43, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0240I001

M.Ishizaki, H.Nakagawa, N.Kawakami, A.Inoue, Y.Morikawa, T.Kido, Y.Yamada: Relationship between job stressand job performance in a factory, The Joint Scientific Meeting of International Epidemiological Association Western
Pacific Region and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of
Epidemiology, 20(Suppl 1):295, 2010.

0240I002

K.Nakamura, W.Hirokawa, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormality and risk of cardiovascular diseases among middle-aged Japanese men,
The Joint Scientific Meeting of International Epidemiological Association Western Pacific Region and 20th Japan
Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology, 20(Suppl 1):191, 2010.

－ 24 －

0240I003

M.Sakurai, M.Nakashima, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, The Joint Scientific Meeting of International Epidemiological Association Western PacificRegion and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology,20(Suppl 1):216, 2010.

0240I004

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse: Association between
long working hours and sleep problems in white-collar workers, The Joint Scientific Meeting of International
Epidemiological Association Western Pacific Region and 20th Japan Epidemiological Association, (Koshigaya,'10.01).

0240I005

K.Kitaoka, M.Nagai, H.Nakagawa, S.Masuda, K.Ogino: Burnout levelo of the Japanese working population, ICOHN& ACOHN Joint Conference 2010, (Yokohama, '10.08).

0240I006

M.Nishijo, W.Swaddiwudhipong, K.Nambunmee, W.Ruangyuttikam, R.Honda, Y.Morikawa, H.Nakagawa: Effect of
cadmium on health risk of arterioselerosis; a study of Thai population environmentary exposed to cadmium, 6thconference on molecular mechanisums of metal toxicity and carcinogenesis, (Kentucky, '10.11).

－ 25 －

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KITAMURA Osamu

Forensic Pathology, Drug Dependence.

Senior Assistant Professor

WANG Lu

Tumor pathology, Endocrine pathology, Forensic pathology.

Assistant Professor

TAKEICHI Toshiaki

hemorheologe.

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

Publications
Originals
0250B001

O.Kitamura, T.Takeichi, L.Wang, I.Tokunaga, A.Ishigami, S.Kubo: Microglial and astrocytic changes in the
striatum of methamphetamine abusers, Leg Med (Tokyo)., 12:57-62, 2010.

0250B002

E.L.Wang, Z.Qian, M.Nakasono, T.Tanahashi, K.Yoshimoto, Y.Bando, E.Kudo, M.Shimada, T.Sano: Highexpression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis incolorectal cancer, Br. J. Cancer, 102:908-915, 2010.

0250B003(A.Ishigami), S.Kubo, O.Kitamura, I.Tokunaga, A.Nishimura: Two autopsy cases that died after surviving a hanging
attempt: significance of hemorrhage around tha larynx and pharynx, The Japanese Journal of Forensic Pathology,
16:40-45, 2010 (in Japanese) .

－ 26 －

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

YASUDA Yukio

Associate Professor

HORI Ariyuki

Senior Assistant Professor

FUKUNAGA
Toshiharu

Assistant Professor

KURODA Naohiro

Facultyundergraduate clinical teaching, graduate education of physicians,
medical education.
medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning.
laboratory medicine, standardization of blood gas analysis, pulmonary
function test.
medical informatics, electronic medical record system, medical
educatin.

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Presentations at Conference
International Conference (Presentations)
0260I001

A.Yamaya, J.Huang, T.Fukunaga, S.Shinomiya, S.Kitadate, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, T.Oikawa,
K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, K.Osanai, H.Toga: Peripheral airway resistance determinedwith the interruption technique in COPD patients, American Thoracic Society 2010 International Conference, (New
Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2118, 2010.

0260I002

M.Saito, J.Huang, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, K.Kojima, Y.Fujimoto, T.Oikawa, K.Nakagawa,
T.Fukunaga, K.Tsuchihara, M.Iguchi, K.Osanai, H.Toga: Upper airway function assessed with negative expiratory
pressure technique during wakefulness in patients with obstructive sleep apnea, American Thoracic Society 2010
International Conference, (New Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2209, 2010.

－ 27 －

－ 28 －

Clinical Medicine

0300

Department of Cardiovascular Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism.

Associate Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention.

Associate Professor

KAWAI Yasuyuki

Ischemic heart disease, Coronary intervention.

Associate
Professor(Additional Post)

ASAJI Takayoshi

Heart failure.

Senior Assistant Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention.

Senior Assistant Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation.

Senior AssistantProfessor(Additional Post)

UENISHI Hiroaki

Ischemic heart disease, Coronary intervention.

Assistant Professor

TAKEDA Kenji

Molecular Biology.

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention.

Assistant Professor

KASENO Kenichi

Arrhythmia, Catheter ablation.

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention.

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension.

Assistant Professor

WAKASA Minoru

Heart failure.

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

Publications
Originals
0300B001(E.Yamashita), H.Takamatsu, H.Tada, H.Toide, H.Okaniwa, N.Takemura, T.Sasaki, Y.Miki, E.Fuke, T.Hayashi,
T.Sakamoto, K.Nakamura, R.Fukazawa, C.Sato, K.Goto, K.Kaseno, K.Kumagai, S.Naito, H.Hoshizaki, S.Oshima:Transesophageal echocardiography for thrombus screening prior to left atrial catheter ablation, Circ. J., 74:10816, 2010.

0300B002(I.Matsunari), H.Aoki, Y.Nomura, N.Takeda, W.P.Chen, J.Taki, K.Nakajima, S.G.Nekolla, S.Kinuya, K.Kajinami:
Iodine-123 metaiodobenzylguanidine imaging and carbon-11 hydroxyephedrine positron emission tomography
compared in patients with left ventricular dysfunction, Circ. Cardiovasc. Imaging., 3:595-603, 2010.

－ 29 －

0300B003(K.Arakawa), T.Kudo, M.Ikawa, N.Morikawa, Y.Kawai, K.Sahashi, J D.Lee, M.Kuriyama, I.Miyamori, H.Okazawa,
M.Yoneda: Abnormal myocardial energy-production state in mitochondrial cardiomyopathy and acute response to
L-arginine infusion －C-11 acetate kinetics revealed by positron emission tomography －, Circ. J., 74:27022711, 2010.

Presentations at Conference
International Conference (Presentations)
0300I001

H.Akao, M.Kitayama, Y.Kawai, R.Ishida, A.Motoyama, M.Wakasa, H.Aoki, R.Saito, K.Fujibayashi, K.Kajinami:
Potential Role of Pentraxin 3(PTX3) in Advanced Coronary Atherosclerosis : Coronary Rotational Atherectomy
Study, The American College of Cardiology 59th Annual Scientific Session, (Atlanta, '10.03).

0300I002

K.Kojima, A.Motoyama, M.Watanabe, K.Tanabe, H.Aoki, R.Saito, H.Akao, Y.Kawai, M.Kitayama, K.Fujibayashi,
K.Kajinami: Lipid profile in japanese patients who developed coronary artery disease during statin therapy, The
78th European Atherosclerosis Society Congress, (Hamburg, '10.06).

－ 30 －

0310

Department of Respirology (Respiratory Medicine)

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

lung physiology, sleep disordered breathing.

Associate Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD.

Senior Assistant Professor

HUANG Jyongsu

lung physiology, sleep disordered breathing.

Senior Assistant Professor

IGUCHI Masaharu

clinical respiratory medicine, lung cancer.

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis.

Assistant Professor

TOBE Takeyasu

clinical respiratory medicine.

Assistant Professor

TSUCHIHARA
Katsumaclinical respiratory medicine, lung cancer.

Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer.

Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer.

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine.

Assistant Professor

KOJIMA Koji

clinical respiratory medicine.

Assistant Professor

KOBAYASHI Makoto lung inflammation.

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep.

Keywords of Research
acute lung injury, cytokine, matrix metalloproteinase, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic
reflection technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001

K.Osanai, J.Higuchi, R.Oikawa, M.Kobayashi, K.Tsuchihara, M.Iguchi, J.Huang, D.R.Voelker, H.Toga: Alteredlung surfactant system in a Rab38-deficient rat model of Hermansky-pudlak syndrome, Am. J. Physiol. Lung Cell
Mol. Physiol., 298:L243-L251, 2010.

0310B002(M.Ichinose), K.Seyama, M.Nishimura, Y.Fukuchi, A.Nagai, M.Mishima, K.Kubo, H.Toga, Beta-2 Agonist
Research and Evaluation Committee in COPD (BAREC) study group: Additive effects of transdermal tulobuterol toinhaled tiotropium in patients with COPD, Respir Med., 104:267-274, 2010.

0310B003(H.Kimura), H.Toga, M.Yamaya, M.Mishima, T.Nukiwa, S.Kudo: Current situations and issues in respiratory
medicine in Japan, JMAJ., 53:178-184, 2010.

－ 31 －

0310B004

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsucihara, K.Nakagawa, T.Sakuma: Lidocaine
administration on the throat under amnesia improves patient satisfaction in flexible bronchoscopy, The Journal of
the Japan Society for Respiratory Endoscopy, 32:409-415, 2010.

0310B005

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, K.Nakagawa, T.Sakuma: Midazolam
for sedation in bronchoscopic examination -a questionnaire on patient satisfaction-, The Journal of the Japan
Society for Respiratory Endoscopy, 32:133-137, 2010 (in Japanese) .

0310B006

Y.Takahara: Involvement of aquaporin 1 and 5 overexpression in metastasis potential of human osteosarcoma, J.
Kanazawa. Med. Univ., 35:113-121, 2010 (in Japanese) .

0310B007

A.Yamaya: Peripheral airway resistance determined with airflow interruption during spontaneous breathing inpatients with chronic obstructive pulmonary disease, J. Kanazawa. Med. Univ., 35:141-151, 2010 (in Japanese) .

Reviews
0310C002

Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami,
S.Katsuda: Aquaporin as a novel player in cancer cell the invasion of cancer cells, J. Kanazawa. Med. Univ.,
35:55-60, 2010 (in Japanese) .

Others
0310F002

Y.Saito, K.Naruhashi, Y.Ikeda, A.Kubo, Y.Takahashi, K.Tsuchihara, K.Nishio: Validation of reducing initial dosageof carboplatin plus weekly paclitaxel for advanced non-small-cell lung cancer based on a voidance of adverse
effects, Japanese journal of pharmaceutical health care and sciences, 36:493-501, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0310I001

A.Yamaya, J.Huang, T.Fukunaga, S.Shinomiya, S.Kitadate, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, T.Oikawa,
K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, K.Osanai, H.Toga: Peripheral airway resistance determinedwith the interruption technique in COPD patients, American Thoracic Society 2010 International Conference, (New
Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2118, 2010.

0310I002

M.Saito, J.Huang, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, K.Kojima, Y.Fujimoto, T.Oikawa, K.Nakagawa,
T.Fukunaga, K.Tsuchihara, M.Iguchi, K.Osanai, H.Toga: Upper airway function assessed with negative expiratory
pressure technique during wakefulness in patients with obstructive sleep apnea, American Thoracic Society 2010
International Conference, (New Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2209, 2010.

－ 32 －

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders.

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease.

Associate Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis.

Senior Assistant Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer.

Senior Assistant Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury.

Senior Assistant Professor

YANO Hirokazu

Clinico-epidemiology of alcoholic liver injury.

Assistant Professor

SHIROEDA Shoko

Clinical feature and treatment of severe acute pancreatitis.

Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis.

Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis.

Assistant Professor

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease.

Assistant
Professor(Additional Post)

SAITO Takashi

Treament for metabolic syndrome.

Faculty

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis－ 33 －

Publications
Originals
0320B001(T.Tahara), T.Shibata, T.Arisawa, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda,
N.Maruyama, T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata: CpG island promoter
methylation (CIHM) status of tumor suppressor genes correlates with morphological appearances of gastric cancer,
Anticancer Res., 30:239-244, 2010.

0320B002(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda, N.Maruyama,
T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata, T.Arisawa: Increased number of CpG
island hypermethylation in tumor suppressor genes of non-neoplastic gastric mucosa correlates with higher risk ofgastric cancer, Digestion, 82:27-36, 2010.

0320B003(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, I.Hirata, T.Arisawa: Homozygous TRPV1 315C
influences the susceptibility to functional dyspepsia, J. Clin. Gastroenterol., 44:e1-e7, 2010.

0320B004(T.Tahara), T.hibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,,
H.Fujita, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, I.Hirata, T.Arisawa: Chronic aspirin use suppresses
CDH1 methylation in human gastric mucosa, Dig. Dis. Sci., 55:54-59, 2010.

0320B005(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda, N.Maruyama,
T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata, T.Arisawa: Association between IL17A, -17F and MIF polymorphisms predispose to CpG island hyper-methylation in gastric cancer, Int. J. Mol.
Med., 25:471-477, 2010.

0320B006

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada,
T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Association between functional
promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan,
Cytokine., 51:173-177, 2010.

0320B007(T.Tahara), T.Shibata, H.Yamashita, D.Yoshioka, I.Hirata, T.Arisawa: Promoter methylation status of multidrug
resistance 1 (MDR1) gene in noncancerous gastric mucosa correlates with Helicobacter Pylori infection and gastriccancer occurrence, Cancer Invest., 28:711-716, 2010.

0320B008(T.Tahara), T.Shibata, F.Wang, H.Yamashita, I.Hirata, T.Arisawa: Genetic polymorphisms of molecules associatedwith innate immune responses, TRL2 and MBL2 genes in Japanese subjects with functional dyspepsia, J. Clin.
Biochem. Nutr., 47:217-223, 2010.

0320B009(M.Okubo), T.Tahara, T.Shibata, H.Yamashita, M.Nakamura, D.Yoshioka, J.Yonemura, T.Ishizuka, T.Arisawa,
I.Hirata: Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese
population, Helicobacter., 15:524-531, 2010.

0320B010(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, J.Yonemura, Y.Maeda, N.Maruyama,
T.Kamano, Y.Kamiya, H.Fujita, Y.Nakagawa, M.Nagasaka, M.Iwata, I.Hirata, T.Arisawa: Association between
cyclin D1 polymorphism with CpG island promoter methylation status of tumor suppressor genes in gastric cancer,
Dig. Dis. Sci., 55:3449-3457., 2010.

0320B011

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka,
H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Functional promoter polymorphisms of macrophagemigration inhibitory factor in peptic ulcer diseases, Int. J. Mol. Med., 26:707-711, 2010.

Reviews
0320C002

T.Arisawa, T.Tahara, M.Nakamura: A genetic background of ulcer diseases induced by NSAID/aspirin, Japanese
Journal of Clinical Medicine, 68:2113-2118, 2010 (in Japanese) .

－ 34 －

Case Reports
0320D001(T.Tahara), T.Shibata, M.Nakamura, H.Yamashita, D.Yoshioka, M.Okubo, N.Maruyama, T.Kamano, Y.Kamiya,
Y.Nakagawa, H.Fujita, M.Nagasaka, M.Iwata, K.Takahama, M.Watanabe, T.Arisawa, I.Hirata: Gastrointestinal
stromal tumor of the stomach with narrow stalk-like based, uneven protruding appearance presenting with severe
acute anemia despite small size, Case Rep Gastroenterol., 4:111-117, 2010.

0320D002(M.Nakamura), T.Shibata, T.Tahara, D.Yoshioka, M.Okubo, Y.Mizoguchi, M.Kuroda, T.Arisawa, I.Hirata: The
usefulness of magnifying endoscopy with narrow-band imaging to distinguish carcinoma in flat elevated lesions inthe stomach diagnosed as adenoma by using biopsy samples, Gastrointest. Endosc., 71:1070-1075, 2010.

0320D003

S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki,
T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi: A case ob jejunal GIST diagnosed by double-baloon endoscopy,
Endosc. Forum digest. dis., 26:44-49, 2010 (in Japanese) .

Short Communications
0320E001(T.Shibata), T.Tahara, J.Yonemura, M.Okubo, D.Yoshioka, M.Nakamura, T.Ishizuka, T.Arisawa, I.Hirata: The Gprotein β3 polymorphism is associated with diffuse type gastric cancer in Japanese, Asian Pac. J. Cancer Prev.,
11:1195-1199, 2010.

Others
0320F001(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, D.Yoshioka, T.Arisawa, I.Hirata.: The mucosal pattern in the nonneoplastic gastric mucosa by using magnifying narrow-band imaging endoscopy significantly correlates with gastriccancer risk, Gastrointest. Endosc., 71:429-430, 2010.

Presentations at Conference
International Conference (Presentations)
0320I001

A.Nakagawa, N.Imaizumi, M.Nishizawa, K.Uehara, T.Fukuyama, T.Arisawa, K.Ishikura, T.Takaｍura, S.Kaneko,
D.Koya: Gene expressions of proprotein convertase4 and furin in tumors causing non-islet cell tumor
hypoglycemia, 14th International Congress of Endocrinology, (Kyoto, '10.03)，Endocrine Jounal (14thInternational Congress of Endocrinology Program & Abstracts), 57(Suppl.2):S584, 2010.

0320I002(T.Tahara), T.Shibata, M.Nakamura, M.Okubo, D.Yoshioka, Y.Nakagawa, M.Iwata, M.Nagasaka, T.Arisawa,
I.Hirata: Increased number of CpG islands hyper methylation(CIHM)of tumoy suppressor genes in non-neoplastic
gastric mucosa correlates with higher risk of gastric cancer(GC)including its various clinoco-pathological subtypes,
Digestive Disease Week 2010, (New Orleans, '10.05).

0320I003(M.Okubo), T.Tahara, T.Shibata, M.Nakamura, D.Yoshioka, T.Arisawa, I.Hirata: Change in gastric mucosal
patterns seen by magnifying NBI endoscopy during H.pylori eradication, Digestive Disease Week 2010, (New
Orleans, '10.05).

0320I004(T.Shibata), T.Tahara, T.Arisawa, I.Hirata: The associations of polymorphisms of inflammatory genes andmcchanisms of functional dyspepsia, Digestive Disease Week 2010, (New Orleans, '10.05).

0320I005(M.Nakamura), T.Shibata, T.Tahara, T.Arisawa, I.Hirata: Usefulness of transnasal endoscopy in areas where
endoscopic submucosal dissection is problematic, Digestive Disease Week 2010, (New Orleans, '10.05).

0320I006(M.Nakamura), T.Shibata, T.Tahara, T.Arisawa, I.Hirata: The effect of PPI-Short term treatment with anti ulcer
drug for cost performance and improvement of ESD-derived artificial ulcer, Asian Pacific Digestive Week,(Malaysia, '10.09).

0320I007(M.Nakamura), T.Shibata, T.Tahara, T.Arisawa, I.Hirata: Usefulness of transnasal endoscopy where endoscopic
submucosal dissection is problematic, Asian Pacific Digestive Week, (Malaysia, '10.09).

－ 35 －

0320I008

J.George, M.Tsutsumi, J.D'Armiento: MMP-13 deletion attenuates N-nitrosodimethylamine induced hepatic
fibrosis in mice, American Association for the Study of Liver Diseases 2010, (Boston, '10.11).

－ 36 －

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation.

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology.

Associate Professor

ASAKA Mitsuhiro

Cellular immunity in uremia, Clinicopathological study of primary
nonfunction and chronic allograft nephropathy in renaltransplantation.

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology.

Senior Assistant Professor

OKUYAMA Hiroshi

Clinical nephrology.

Assistant Professor

ADACHI Hiroki

Clinical nephrology.

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology.

Assistant Professor

NAKAGAWA Masaru Clinical nephrology.

Assistant Professor

HAYAMA Satoshi

Clinical nephrology.

Assistant Professor

ATSUMI Hirokatsu

Clinical nephrology.

Assistant Professor

IMURA Junko

Clinical nephrology.

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology.

Assistant Professor

KIMURA Shogo

Clinical nephrology.

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

－ 37 －

Publications
Originals
0330B001(M.Matsumoto), T.Tsujino, Masaaki Lee-Kawabata, Y.Naito, H.Akahori, T.Sakoda, M.Ohyanagi, N.Tomosugi,
T.Masuyama: Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia, Circ. J.,
74:301-306, 2010.

0330B002(M.Hashizume), Y.Uchiyama, N.Horai, N.Tomosugi, M.Mihara: Tocilizumab, a humanized anti-interleukin-6
receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-inducued hepcidin production,
Rheumatol. Int., 30:917-923, 2010.

0330B003(Y.Kaneko), H.Miyajima, A.Piperno, N.Tomosugi, H.Hayashi, N.Morotomi, K.Tsuchida, T.Ikeda, A.Ishikawa,
Y.Ota, S.Wakusawa, K.Yoshioka, S.Kono, S.Pelucchi, A.Hattori, Y.Tatsumi, T.Okada, M.Yamagishi: Measurementof serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders, J.
Gastroenterol., 45:1163-1171, 2010.

0330B004(S.Kono), K.Yoshida, N.Tomosugi, T.Terada, Y.Hamaya, S.Kanaoka, H.Mitajima: Biological effects of mutant
ceruloplasmin on hepcidin-mediated internalization of ferroportin, Biochim. Biophys. Acta, 1802:968-975, 2010.

0330B005(S.Nakazawa J.Song), N.Tomosugi, H.Kawabata, T.Ishikawa, T.Nishikawa, K.Yoshizaki: Down-regulation of
hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia ofinflammation in multicentric Castleman disease, Blood, 116:3627-3634, 2010.

0330B006(H.Hayashi), A.Piperno, N.Tomosugi, K.Hayashi, F.Kimura, S.Wakusawa, M.Yano, Y.Tatsumi, A.Hattori,
S.Pelucchi, Y.Katano, H.Goto: Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity thanpatients with HFE-hemochromatosis, Intern. Med., 49:2371-2377, 2010.

0330B007(T.Kosuge), T.Sawada, M.Shimoda, J.Kita, N.Tomosugi, K.Kubota: Increased hepcidin production impairs ironmetabolism after pancreatoduodenectomy, World J Surg., 34:2452-2456, 2010.

0330B008

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology, 24:8-13, 2010.

0330B009

A.Saito, Y.Matsumoto, Y.Oyama, M.Asaka, H.Yokoyama: Effectiveness of weekly percutaneous maxacalcitol
injection therapy in patients with secondary hyperparathyroidism, Ther Apher Dial, 14:98-103, 2010.

0330B010(I.Ishikawa), S.Hayama, K.Morita, T.Nakazawa, H.Yokoyama, R.Honda, K.Satoh, T.Kakuma: Long-term natural
history of acquired cystic disease of the kidney, Ther Apher Dial, 14:409-416, 2010.

0330B011

S.Kimura: A new insight into circulating fibrocytes in human renal allograft fibrosis, J. Kanazawa. Med. Univ.,
35:106-112, 2010 (in Japanese) .

Case Reports
0330D001

H.Atsumi, M.Asaka, S.Kimura, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Okuyama, H.Yamaya,
M.Moriyama, T.Tanaka, K.Suzuki, H.Yokoyama: A case of second renal transplantation with acute antibodymediated rejection complicated with BK virus nephropathy, Clin. Transplant., 24:35-38, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0330G001

H.Yokoyama: 2010 Report of J-RBR(Japan Renal Biopsy Registry) and J-KDR(Japan Kidney Disease Registry)Data base for clinicopathological studies constructed by the Japanese Society of Nephrology, The 4th Research
Forum on Chronic Kidney Disease, (Nagoya, '10.02).

－ 38 －

International Conference (Synposium)
0330H001

H.Yokoyama: Non-immunological factors and non-classical HLA class I in chronic allograft injury(CAI), Scientific
Joint Meeting 2010, (Uchinada, '10.05).

0330H002

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

International Conference (Presentations)
0330I001

H.Yamaya, H.Adachi, S.Kimura, M.Asaka, H.Yokoyama: Statins and lower LDL-C/HDL-C ratio preserved thefunction of transplanted kidneys under controlled blood pressure, The kidney and the vascular system:emerging
culprits in pathogenesis and advances in therapy, (Kyoto, '10.04).

0330I002(A.Nakagawa), K.Yamamoto, H.Sako, T.Yoshimoto, K.Hara, S.Urashima, S.Kawaguchi, S.Nakano, D.Koya,
H.Yokoyama: The effects of a vitamin micrnutrient bebeverage (VCRESC) on end stage renal failure (ESKD)
patients vitamin and homocysteine (Hcy) values after long term consumption, it is a case report, The kidney andthe vascular system:emerging culprits in pathogenesis and advances in therapy, (Kyoto, '10.04).

0330I003

A.Nakagawa, K.Yamamoto, H.Sako, T.Yoshimoto, K.Hara, S.Urashima, S.Kawaguchi, S.Nakano, D.Koya,
H.Yokoyama: The effects of a vitamin micrnutruent bebeverage (VCRESC) on end stage renal failure (ESKD)
paitient vitamin and homocysteine (Hcy) values after long term consumption, it is a case report, Kidney and
Vascular System: Emerging Culprits in Pathogenesis and Advances in Therapy, (Kyoto, '10.04)，Kidney and
Vascular System: Emerging Culprits in Pathogenesis and Advances in Therapy Final (Program & book of
abstracts), 167, 2010.

－ 39 －

0340

Department of Endocrinology and Metabolism

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging.

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases.

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases.

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis.

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis.

Assistant Professor

ITO Hiroki

adrenal diseases, diabetes, thyroid diseases.

Assistant Professor

IMAIZUMI Noriko

diabetes.

Assistant Professor

FURUYA Keisuke

diabetes, thyroid diseases.

Assistant Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension.

Assistant Professor

ASTUMI Hisanari

diabetes.

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001(K.Shikata), M.Haneda, D.Koya, Y.Suzuki, Y.Tomino, K.Yamada, S.Maeda, N.Kawakami, T.Uzu, M.Nishimura,
C.Sato, D.Ogawa, H.Makino: Diabetic nephropathy remission and regression team trial in Japan (DNETT-Japan):rationale and study design, Diabetes Res. Clin. Pract., 87:228-232, 2010.

0340B002(J.Nakazawa), K.Isshiki, T.Sugimoto, S.Araki, S.Kume, Y.Yokomaku, M.C.Kanasaki, M.Sakaguchi, D.Koya,
M.Haneda, A.Kashiwagi, T.Uzu: Renoprotective effects of asialoerythropoietin in diabetic mice against ischaemiareperfusion-induced acute kidney injury, Nephrology (Carlton)., 15:93-101, 2010.

－ 40 －

0340B003(S.Kume), T.Uzu, K.Horiike, M.C.Kanasaki, K.Isshiki, S.Araki, T.Sugimoto, M.Haneda, A.Kashiwagi, D.Koya:
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouseaged kidney, J. Clin. Invest., 120:1043-1055, 2010.

0340B004(K.Yamagata), H.Makino, T.Akizawa, K.Iseki, S.Itoh, K.Kimura, D.Koya, I.Narita, T.Mitarai, M.Miyazaki,
Y.Tsubakihara, T.Watanabe, T.Wada, O.Sakai: Design and methods of a strategic outcome study for chronic
kidney diseasa:frontier of renal outcome modifications in Japan, Clin. Exp. Nephrol., 14:144-151, 2010.

0340B005(S.Araki), M.Haneda, D.Koya, K.Isshiki, S.Kume, T.Sugimoto, H.Kawai, Y.Nishio, A.Kashiwagi, T.Uzu,
H.Maegawa: Association between urinary type IV collagen level and deterioration of renal function in type 2
diabetic patients without overt proteinuia, Diabetes Care., 33:1805-1810, 2010.

0340B006(M.Kikuchi), M.Haneda, D.Koya, K.Tobe, Y.Onishi, A.Couturier, N.Mimori, Y.Inaba, M.Goodman: Efficacy andtolerability of vildagliptin as an add-on to glimepiride in Japanese patients with type 2 diabetes mellitus, Diabetes
Res. Clin. Pract., 89:216-223, 2010.

0340B007(M.Soumura), S.Kume, K.Isshiki, N.Takeda, S.Araki, Y.Tanaka, T.Sugimoto, M.C Kanasaki, Y.Nishio, M.Haneda,
D.Koya, A.Kashiwagi, H.Maegawa, T.Uzu: Oleate and eicosapentaenoic acid attenuate palmitate-induced
inflammation and apoptosis in renal proximal tubular cell, Biochem. Biophys. Res. Commun., 402:265-271, 2010.

Reviews
0340C001

M.Kitada, Z.Zhang, A.Mima, G.L.King: Molecular mechanisms of diabetic vascular complications, JDI., 1:77-89,
2010.

0340C002(S.Kume), T.Uzu, A.Kashiwagi, D.Koya: SIRT1, a calorie restriction mimetic, in a new therapeutic approach for
type 2 diabetes mellitus and diabetic vascular complications, Endocr. Metab. Immune Disord. Drug Targets, 10:1624, 2010.

0340C003

F.Liang, D.Koya: Acupuncture:is it effective for treatment of insulin resistance?, Diabetes Obes Metab., 12:555569, 2010.

Case Reports
0340D001

K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, J.
Kanazawa. Med. Univ., 35:13-15, 2010.

0340D002

K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypernatremia, rhabdomyolysis and acute renal failure, J. Kanazawa. Med. Univ., 35:68-69, 2010.

Others
0340F001(J.A.Baur), D.Chen, E.N.Chini, K.Chua, H.Y.Cohen, R.de Cabo, C.Deng, S.Dimmeler, D.Gius, L.P.Guarente,
S.L.Helfand, S.Imai, H.Itoh, T.Kadowaki, D.Koya, C.Leeuwenburgh, M.Mcburney, Y.Nabeshima, C.Neri,P.Oberdoerffer, R.G.Pestell, B.Rogina, J.Sadoshima, V.Sartorelli, M.Serrano, D.A.Sinclair, C.Steegborn, M.Tatar,
H.A.Tissenbaum, Q.Tong: Dietary restriction: standing up for sirtuins, Science (80- )., 329:1012-1013, 2010.

Presentations at Conference
International Conference (Presentations)
0340I001

O.Tachibana, Y.Sasagawa, K.Torigoe, S.Siraga, K.Yamamoto, K.Okamoto, T.Iida, T.Akai, H.Iizuka, A.Nakagawa,D.Koya: Inflammatory cytokines from Rathke cleft cysts are possible inducers of secondary hypophysitis, 14th
International Congress of Endocrinology, (Kyoto, '10.03)，Endocrine Jounal (14th International Congress of
Endocrinology Program & Abstracts), 57(Suppl.2):S507, 2010.

－ 41 －

0340I002

D.Koya, S.Kume, E.Kobori: Effectiveness of calorie restriction on ameliorating diabetic nephropathy possibly
through its anti-inflammatory action, 14th International Congress of Endocrinology, (Kyoto, '10.03)，Endocrine
Jounal (14th International Congress of Endocrinology Program & Abstracts), 57(Suppl.2):S563, 2010.

0340I003

A.Nakagawa, N.Imaizumi, M.Nishizawa, K.Uehara, T.Fukuyama, T.Arisawa, K.Ishikura, T.Takaｍura, S.Kaneko,
D.Koya: Gene expressions of proprotein convertase4 and furin in tumors causing non-islet cell tumor
hypoglycemia, 14th International Congress of Endocrinology, (Kyoto, '10.03)，Endocrine Jounal (14thInternational Congress of Endocrinology Program & Abstracts), 57(Suppl.2):S584, 2010.

0340I004

O.Tachibana, Y.Sasagawa, K.Torigoe, K.Yamamoto, S.Siraga, K.Okamoto, T.Akai, H.Iizuka, A.Nakagawa, D.Koya:
Expression of interleukin-1 β, interleukin-6, interleukin-12p40 and TNF α in human Rathke cleft cysts-A
possible inducer of secondary hypophysitis associated with Rathke clef cyst-, 14th International Congress of
Endocrinology, (Kyoto, '10.03).

0340I005

D.Koya, K.Shikata, H.Makino: Diabetic nephropathy remission and remission team trial in Japan (DNETT-Japan),
3rd Korea-Japan-Chaina Kidney conference, (Korea, '10.03)

0340I006(A.Nakagawa), K.Yamamoto, H.Sako, T.Yoshimoto, K.Hara, S.Urashima, S.Kawaguchi, S.Nakano, D.Koya,
H.Yokoyama: The effects of a vitamin micrnutrient bebeverage (VCRESC) on end stage renal failure (ESKD)
patients vitamin and homocysteine (Hcy) values after long term consumption, it is a case report, The kidney andthe vascular system:emerging culprits in pathogenesis and advances in therapy, (Kyoto, '10.04).

0340I007(S.Kume), T.Uzu, S.Araki, M.Haneda, D.Koya: Calorie restriction enhances cell adaptation to hypoxia throughSirt1-dependent mitochondrial autophagy in mouse aged kidney, Kidney and Vascular System: Emerging Culprits in
Pathogenesis and Advances in Therapy, (Kyoto, '10.04)，Kidney and Vascular System: Emerging Culprits in
Pathogenesis and Advances in Therapy Final (Program & book of abstracts), 120, 2010.

0340I008(S.Araki), M.Haneda, D.Koya, A.Kashiwagi, H.Maegawa, T.Uzu: Increased urinary typeⅣ collagen level predicts adeterioration of renal function in type2 diabetic patients without overt proteinuria, Kidney and Vascular System:
Emerging Culprits in Pathogenesis and Advances in Therapy, (Kyoto, '10.04)，Kidney and Vascular System:
Emerging Culprits in Pathogenesis and Advances in Therapy Final (Program & book of abstracts), 144, 2010.

0340I009

A.Nakagawa, K.Yamamoto, H.Sako, T.Yoshimoto, K.Hara, S.Urashima, S.Kawaguchi, S.Nakano, D.Koya,
H.Yokoyama: The effects of a vitamin micrnutruent bebeverage (VCRESC) on end stage renal failure (ESKD)
paitient vitamin and homocysteine (Hcy) values after long term consumption, it is a case report, Kidney and
Vascular System: Emerging Culprits in Pathogenesis and Advances in Therapy, (Kyoto, '10.04)，Kidney and
Vascular System: Emerging Culprits in Pathogenesis and Advances in Therapy Final (Program & book of
abstracts), 167, 2010.

－ 42 －

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

UMEHARA Hisanori

Hematology and Immunology.

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology.

Associate Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine.

Associate Professor

TANAKA Masao

Rheumatology, Immunology.

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology.

Assistant Professor

SAWAKI Toshioki

Hematology and Immunology.

Assistant Professor

KAWANAMI Takafumi Hematology and Immunology.

Assistant Professor

JIN Zhexiong

Immunology.

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology.

Research Doctor

MIKI Miyuki

Hematology and Immunology.

Keywords of Research
autoimmune disorder, Sjögren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
A) Studies of immunological abnormalities and pathophysiology of autoimmune diseases: 1) Effects of chemokines on
vascular injury and Th1 response during chronic inflammation. 2) Function of microdomain (lipid rafts) on lymphocyte
activation and its contribution in autoimmune diseases. 3) Analysis of immunological disorder in sphingomyelin knockout
mice. 4) Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis. 5) Detection of stem cells insalivary glands and its implication for regenerative medicine.
B) Studies of hematological malignancies and development of anti-cancer drugs. 1) Analysis of EB-virus proteins and theirroles in lymphoproliferative disorders. 2) Molecular biological analysis of drug resistance. 3) Roles of sphingomyelin on
apoptosis.

Publications
Originals
0350B001(E.Lafont), D.Milhas, S.Carpentier, V.Garcia, Z.Jin, H.Umehara, T.Okazaki, K.Schulze-Osthoff, T.Levade,
H.Benoist, B.Segui: Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell
death, Cell Death Differ., 17:642-654, 2010.

0350B002(K.Shimada), T.Murase, K.Matsue, M.Okamoto, N.Ichikawa, N.Tsukamoto, N.Niitsu, H.Miwa, H.Asaoku,
H.Kosugi, A.Kikuchi, M.Matsumoto, Y.Saburi, Y.Masaki, K.Yamamoto, M.Yamaguchi, S.Nakamura, T.Naoe,
T.Kinoshita: Central nervous system involvement in intravascular large B-cell lymphoma: a retrospective analysisof 109 patients, Cancer Sci., 101:1480-1486, 2010.

－ 43 －

0350B003

Y.Jiang, Z.Jin, H.Umehara, T.Ota: Cholesterol-dependent induction of dendrite formation by ginsenoside Rh2 incultured melanoma cells, Int. J. Mol. Med., 26: 787-793, 2010.

0350B004(T.Sato), T.Fujii, T.Yokoyama, Y.Fujita, Y.Imura, N.Yukawa, D.Kawabata, T.Nojima, K.Ohmura, T.Usui,
T.Mimori: Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatricmanifestations in systemic lupus erythematosus and mixed connective tissue disease, Arthritis Rheum, 62:37303740, 2010.

0350B005

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

0350B006

C.Huang, Z.Jin, L.Dong, X.Tong, S.Yue, T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, Y.Masaki,
Y.Fukushima, M.Tanaka, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara: Cisplatin augments FAS-mediatedapoptosis through lipid rafts, Anticancer Res., 30:2065-2072, 2010.

0350B007

Y.Cao, Z.Jin, X.Tong, S.Yue, T.Sakai, T.Kawanami, T.Sawaki, M.Miki, H.Iwao, A.Nakajima, Y.Masaki,
Y.Fukushima, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara: Synergistic effects of topoisomerase I inhibitor, SN38,
on Fas-mediated apoptosis, Anticancer Res., 30:3911-3918, 2010.

0350B008(Y.Takamatsu), K.Sunami, H.Hata, K.Nagafuji, I.Choi, M.Higuchi, K.Uozumi, Y.Masaki, K.Tamura: A phase I
study of bortezomib in combination with doxorubicin and intermediate-dose dexamethasone (iPAD therapy) for
relapsed or refractory multiple myeloma, Int. J. Hematol., 92:503-509, 2010.

0350B009

M.Tanaka, K.Murakami, S.Ozaki, Y.Imura, X.Tong, T.Watanabe, T.Sawaki, T.Kawanami, D.Kawabata, T.Fujii,
T.Usui, Y.Masaki, T.Fukushima, Z.Jin, H.Umehara, T.Mimori: DIP2 disco-interacting protein 2 homolog A(Drosophila) is a candidate receptor for follistatin-related protein/follistaitin-like 1 - analysis of their binding with
TGF-β superfamily proteins, FEBS J., 277:4278-4289, 2010.

0350B010(T.Saeki), S.Nishi, N.Imai, T.Ito, H.Yamazaki, M.Kawano, M.Yamamoto, H.Takahashi, S.Matsui, S.Nakada,T.Origuchi, A.Hirabayashi, N.Homma, Y.Tsubata, T.Takata, Y.Wada, A.Saito, S.Fukase, K.Ishioka, K.Miyazaki,
Y.Masaki, H.Umehara, S.Sugai, I.Narita: Clinicopathological characteristics of patients with IgG4-related
tubulointerstitial nephritis, Kidney Int., 78:1016-1023, 2010.

0350B011(Y.Sato), M.Kojima, K.Takata, T.Morito, K.Mizobuchi, T.Tanaka, D.Inoue, H.Shiomi, H.Iwao, T.Yoshino:Multicentric castleman's disease with abundant IgG4-positive cells: a clinical and pathological analysis of six cases,
J. Clin. Pathol., 63:1084-1089, 2010.

0350B012

A.Nakajima: Transcriptome analysis of IgG4-related disease, J. Kanazawa. Med. Univ., 35:89-96, 2010 (inJapanese) .

0350B013

H.Iwao: Proteomics analysis in IgG4-related disease, J. Kanazawa. Med. Univ., 35:131-139, 2010 (in Japanese) .

0350B014

M.Miki: DNaseI activity in patients with systemic lupus erythematosus(SLE), J. Kanazawa. Med. Univ., 35:159165, 2010 (in Japanese) .

Reviews
0350C001(Y.Sato), K.Notohara, M.Kojima, K.Takata, Y.Masaki, T.Yoshino: IgG4-related disease:historical overview andpathology of hematological disorders, Pathol. Int., 60:247-258, 2010.

0350C002

Y.Masaki, S.Sugai, H.Umehara: IgG4-related diseases including Mikulicz's disease and sclerosing pancreatitis:
diagnostic insights, J. Rheumatol., 37:1380-1385, 2010.

Case Reports
0350D001

M.Matoba, K.Oota, H.Tonami, Y.Masaki, T.Sakai, H.Umehara: Palliative radiotherapy with 1 x 8 Gy using
conformal radiotherapy for chemotherapy-refractory, recurrent, aggressive lymphomas, Jpn. J. Radiol., 28:220223, 2010.

－ 44 －

0350D002

T.Fukushima, T.Nakamura, M.Miki, T.Sakai, H.Iwao, A.Nakajima, T.Sawaki, Y.Fujita, M.Tanaka, Y.Masaki,
Y.Hirose, H.Umehara: Complete response obtained by bortezomib plus dexamethasone in a patient with relapsed
multiple myeloma with multiple plasmacytomas, Anticancer Res., 30:3791-3794, 2010.

0350D003

M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: Primary neurolymphomatosis of the cervical nerve root,
The Japanese Journal of Clinical Hematology, 51:564-567, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0350I001

H.Umehara, L.Dong, K.Watanabe, T.Okazaki: Impaired T cell functions in SMS1-knock out mice, 14th
International congress of immunology, (Kobe, '10.08).

0350I002

Y.Fujita, H.Yamagiwa, T.Mimori, H.Umehara: Leptin protects B lymphocytes from starvation-induced apoptosis,
14th International congress of immunology, (Kobe, '10.08).

0350I003

T.Kawanami, T.Sawaki, T.Sakai, H.Iwao, A.Nakajima, M.Miki, Z.Jin, Y.Fujita, M.Tanaka, Y.Masaki, T.Fukushima,
H.Umehara: Identification of human salivary stem cells from cultured labial minor salivary cells, 14th International
congress of immunology, (Kobe, '10.08).

－ 45 －

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology.

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology.

Senior Assistant Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology.

Senior Assistant Professor

KAWAMURA
Kazuyuki

Clinical neurology, Neuroimmunology.

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology.

Assistant Professor

GONDO Yuichiro

Clinical neurology.

Assistant Professor

NAKATA Michiyo

Clinical neurology.

Research Associate

INADA Hiroyuki

Applied animal science.

Research Doctor

HASHIBA Naomi

Clinical neurology.

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroinnunology, neuroinfection, experimental autoimmune encephalomyelitis

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(M.Matsui), M.Tahara, M.Tanaka, K.Tanaka, M.Matsui, T.Konishi: CD8+CD11a high cells decreased in multiple
sclerosis but not in neuromyelitis optica, Eur. Neurol., 63:159-163, 2010.

0360B002(T.Shimohata), K.yanagawa, K.Tanaka, M.Nishizawa: Clinical features of poor-prognosis with adult bacterial
meningitis, Clinical Neurology, 50：137-140, 2010 (in Japanese) .

0360B003(T.Oda), F.Kanda, H.Hamaguchi, K.Tanaka, T.Toda: Clinical features and response to treatment in patients
positive anti-aquaporin-4 antibody, Neurological Medicine, 73：194-198, 2010 (in Japanese) .

0360B004(T.Kezuka), Y.Matsunaga, A.Kobayashi, Y.Moritake, M.Takagi, K.Tanaka, H.Goto: Visual field in optic neuritis
with seropositive anti-aquaporin 4 antibody, Japanese journal of clinical ophthalmology Rinsho ganka., 64：317322, 2010 (in Japanese) .

Reviews
0360C001

K.Tanaka: pathogenesis of paraneoplastic neurological syndromes, Brain and nerve., 62：309-318, 2010 (inJapanese) .

0360C002

K.Tanaka: Anti-Purkinje cell antibody(Anti-Yo/type 1 antibody), Japanese Journal of Clinical Medicine, 68：526529, 2010 (in Japanese) .

－ 46 －

0360C003

K.Tanaka: Anti-NMDA receptor antibody, Japanese Journal of Clinical Medicine, 68:651-654, 2010 (in Japanese) .

0360C004

K.Tanaka: Paraneoplastic neurological syndromes with reference to anti-neuronal autoantibodies, Clinical
Neurology, 50：371-378, 2010 (in Japanese) .

0360C006

K.Tanaka, M.Tanaka: Differential diagnosis of neuromyelitis optica spectrum disorders, Brain and nerve., 62：953960, 2010 (in Japanese) .

Case Reports
0360D001

M.Nakanishi, M.Kaito, Y.Gondo, H.Takada, M.Matsui, G.Hirose: Moyamoya disease presenting with an acuteconfusional state in an elderly patient, J. Stroke Cerebrovasc. Dis., 247-250, 2010.

0360D002(N.Tachibana), T.Shirakawa, K.Ishii, Y.Takahashi, K.Tanaka, K.Arima, T.Yoshida, S.Ikeda: Expression of various
glutamate receptors including N-Methyl-D-Aspartate Receptor (NMDAR) in an ovarian teratoma removed from ayoung woman with anti-NMDAR encephalitis, Intern. Med., 49:2167-2173, 2010.

0360D003(A.Tanaka), T.Yoshida, T.Yamada, R.Isayama, Y.Fujiwara, K.Shiga, K.Yamada, K.Tanaka, M.Nakagawa: A case of
cerebral aquaporinopathy, Mult.Scler, 16:1252-1254, 2010.

0360D004(M.Ogasawara), K.Shikishima, T.Sakai, M.Takagi, K.Tanaka: A case of neuromyelitis optica developing into
myelitis 25 years after optic neuritis, Jpn. J. Ophthalmol., 54:372-373, 2010.

0360D005(H.Yoshida), A.Ando, K.Sho, M.Akioka, E.Kawai, E.Arai, T.Nishimura, A.Shinde, H.Masaki, K.Takahashi,
M.Takagi, K.Tanaka: Anti-aquaporin-4 antibody-positive optic neuritis treated with double-filtration
plasmapheresis, J. Ocul. Pharmacol. Ther., 26:381-385, 2010.

0360D006(K.Tesseki), H.Kataoka, M.Terashima, M.Kawahara, T.Taoka, K.Tanaka, S.Ueno: Biphasic paraneoplastic
brainstem encephalitis associated with anti-Ri antibody, J. Neurooncol., 100:141-143, 2010.

0360D007

M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: Primary neurolymphomatosis of the cervical nerve root,
The Japanese Journal of Clinical Hematology, 51:564-567, 2010 (in Japanese) .

Short Communications
0360E001(R.Motoyama), K.Shiraishi, K.Tanaka, M.Kinoshita, M.Tanaka: Anti-NMDA receptor antibody encephalitis withrecurrent optic neuritis and epilepsy, Clinical Neurology, 50；585-588, 2010 (in Japanese) .

Others0360F001(T.Sano), K.Tanaka, N.Ito: Anti-Hu-antibody-associated paraneoplastic neurological syndrome accompanying
testicular cancer, Int. J. Urol., 17:99, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0360G001

M.Matsui, N.Hashiba, S.Araya, H.Inada, S.Nagayama, K.Tanaka, T.Konishi: Differences in cellular immunity
associated with active disease in patients with MS and NMO, 10th International Congress of Neuroimmunology,(Barcelona, '10.10).

International Conference (Presentations)
0360I001

K.Tanaka, M.Nakata, M.Matsui, K.Sakimura: Clinical spectrum of anti-NMDA receptor antibody related
encephalitis diagnosed by cell-based immunofluorescense detection system, 10th International congress of
Neuroimmunology, (Barcelona, '10.10).

－ 47 －

0560

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology.

Associate Professor

NAKAJIMA Hideo

Medical Oncology, Immunology, Molecular Biology.

Senior Assistant Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics.

Assistant Professor

NAKAYA Naoki

Medical Oncology.

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0560B001

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A Kampo medicine, boiogito,
inhibits obesity in ovariectomized rats, Evid Based Complement Alternat Med, 7:87-95, 2010.

0560B002(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of KRAS testing and cetuximab as last-line therapy
for colorectal cancer, Mol Diagn Ther., 14:375-384, 2010.

0560B003

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

0560B004

C.Huang, Z.Jin, L.Dong, X.Tong, S.Yue, T.Kawanami, T.Sawaki, T.Sakai, M.Miki, H.Iwao, A.Nakajima, Y.Masaki,
Y.Fukushima, M.Tanaka, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara: Cisplatin augments FAS-mediatedapoptosis through lipid rafts, Anticancer Res., 30:2065-2072, 2010.

0560B005

Y.Cao, Z.Jin, X.Tong, S.Yue, T.Sakai, T.Kawanami, T.Sawaki, M.Miki, H.Iwao, A.Nakajima, Y.Masaki,
Y.Fukushima, Y.Fujita, H.Nakajima, T.Okazaki, H.Umehara: Synergistic effects of topoisomerase I inhibitor, SN38,
on Fas-mediated apoptosis, Anticancer Res., 30:3911-3918, 2010.

0560B007

N.Nakaya: TP53INP1 Regulates the cellular sensitivity to gemcitabine, J. Kanazawa. Med. Univ., 35:152-158, 2010
(in Japanese) .

Reviews
0560C001(C.Cano), Y.Motoo, JL.Lovanna: Epithelial- to- mesenchymal transition in pancreatic adenocarcinoma, ScientificWorld Journal., 10:1947-1957, 2010.

－ 48 －

0560C002

T.Shimasaki, Y.Ishigaki, T.Minamoto, Y.Motoo: Application of molecular medicine to pancreatic cancer, The
Journal of Japan Pancreas Society, 25:35-45, 2010 (in Japanese) .

Case Reports
0560D001(M.Tachibana), Y.Hashimoto, T.Sone, N.Ooishi, T.Ueno, Y.Motoo: Two cases of atypical adenoma of the
thyroid―is atypical adenoma of the thyroid a true benign lesion?―, J. Jpn. Soc. Clin. Cytol., 49:190-195, 2010
(in Japanese) .

0560D003

J.Moriya, J.Yamakawa, Y.Motoo: A case of carpal tunnel syndrome treated by the combination with san'oshashinto
and tokakujokito, Pain and kampo medicine, 20:81-83, 2010 (in Japanese) .

0560D004

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy, 37:1341-1344, 2010 (in Japanese) .

Others0560F001(Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki: Molecular analysis on responses of TP53INP1-knockout
mouse embryonic fibroblasts to anti-cancer agents, Study report 2009 Japan China Sasakawa Medical Fellowship,
125-128, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0560G001

Y.Motoo, K.Tsutani: “Tsutaeru ” Project on evidence of Kampo medicine: activities of the special committee for
EBM, Japan Society for Oriental Medicine, The 15th International Congress of Oriental Medicine, (Makuhari,'10.02).

0560G002

Y.Motoo: Traditional Japanese medicine in clinical practice guidelines and in multidisciplinary cancer treatment,
The 14th International Conference on Oriental Medicine of Daegu Haany & Dong-Eui University 2010, (Daegu,'10.11).

International Conference (Synposium)
0560H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

0560H002

Y.Motoo: Stress responses of pancreatic cancer cells and their significance in invasion and metastasis,
International Symposium on Primo-Vascular System 2010, (Jecheon, '10.09).

0560H003

Y.Motoo: Current status of cancer treatment in Japan, Academic lecture series on cancer: basic and clinicalaspects, (Shanghai, '10.09).

0560H004

Y.Motoo: East Meets West: Japanese experience with special reference to cancer treatment, The First BeijingInternational Symposium on Integrative Medicine, (Beijing, '10.10).

0560H005

Y.Motoo: Clinical practice guidelines containing Kampo products in Japan, First Korea-Japan Workshop on EBM
in Traditional East Asian Medicine, (Seoul, '10.10).

0560H006

Y.Motoo: New Work Item Proposal (NWIP) No.2 from Japan, Joint ISO/TC215 and CEN/TC251 Working Groups
meeting, (Rotterdam, '10.10).

－ 49 －

International Conference (Presentations)
0560I001

J.Yamakawa, J.Moriya, Y.Motoo: Three kampo medicines have different activities to regulate gene expressions indifferentiated rat white adipocytes, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0560I002

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0560I003

Y.Motoo, T.Togo, H.Toyotama, T.Seki: New work item proposal of traditional medicine, ISO/TC215 WG3 TMTF, (Rio de Janeiro, '10.05).

0560I004

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis and inhibiting apoptosis of granular cells, The 9th Meeting of the Consortium for
Globalization of Chinese Medicine 2010, (Hong Kong, '10.08).

0560I005(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of K-ras testing and cetuximab for metastatic
colorectal cancer in Japan, ISPOR 4th Asia-Pacific Conference, (Phuket, '10.09).

－ 50 －

0565

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention.

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs－ 51 －

0630

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

YAMAKAWA Junichi

General medicine, Kampo medicine.

Assistant Professor

MORIYA Junji

General medicine, Kampo medicine.

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0630B001

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A Kampo medicine, boiogito,
inhibits obesity in ovariectomized rats, Evid Based Complement Alternat Med, 7:87-95, 2010.

0630B002

R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda: The effects of a
PPARα agonist on myocardial damage in obese diabetic mice with heart failure, Int. Heart J., 51:199-206, 2010.

0630B003

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

Reviews
0630C001

R.Chen, J.Moriya, J.Yamakawa, T.Takahashi, T.Kanda: Traditional chinese medicine for chronic fatigue syndrome,
Evid Based Complement Alternat Med, 7:3-10, 2010.

Case Reports
0630D002

J.Moriya, J.Yamakawa, Y.Motoo: A case of carpal tunnel syndrome treated by the combination with san'oshashinto
and tokakujokito, Pain and kampo medicine, 20:81-83, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0630I001

J.Yamakawa, J.Moriya, Y.Motoo: Three kampo medicines have different activities to regulate gene expressions indifferentiated rat white adipocytes, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0630I002

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0630I003

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis and inhibiting apoptosis of granular cells, The 9th Meeting of the Consortium for
Globalization of Chinese Medicine 2010, (Hong Kong, '10.08).

－ 52 －

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis.

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology.

Senior Assistant Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology.

Senior Assistant Professor

TSUCHIYA Hiroshi

Geriatrics, Circulation, Atherosclerosis.

Assistant Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis.

Assistant Professor

NOMURA Koji

Geriatrics, Circulation.

Assistant Professor

SATO Kazuto

Geriatrics, Circulation.

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation.

Assistant Professor

ISHIGAMI Keiichiro

Geriatrics, Dementia.

Assistant Professor

ATSUMI Mikiko

Geriatrics, Circulation.

Research Doctor

OHASHI Isao

Geriatrics, Hypertension, Atherosclerosis.

Research Doctor

TAKATA MeikoGeriatrics.

Faculty

Keywords of Researchelderly, cardiac function, mitral stenosis, dynamic exercise, flow convergence region, dementia, computer, diastolic function,
ultrasound, aortic distensidility, adenocarcinoma, stroke volume, carotid arterial stiffness, high frequency ultrasound,
hypertension, antihypertensive treatment, color Doppler echocardiography, echocardiography, diabetes mellitus, cardiac
disease, carotid artery, atherosclerosis, isolated systolic hypertension, Double cancer, squamous carcinoma, cardicac
output, carotid arterial elastic modulus, Hasegawa ﾕ s dementia scale, eicosapentaenoic acid, nitrendipine

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001

R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda: The effects of a
PPARα agonist on myocardial damage in obese diabetic mice with heart failure, Int. Heart J., 51:199-206, 2010.

0370B002

H.Yoshimura, S.Morimoto, M.Okuro, N.Segami, N.Kato: Evaluations of dementia by EEG frequency analysis andpsychological examination, J. Physiol. Sci., 60:383-388, 2010.

－ 53 －

0370B003

M.Atsumi, Y.Koizumi, K.Ishigami, K.Satoh, O.Iritani, M.Okuro, S.Morimoto: Increased level of LDL cholesterol inelderly patients with acute ischemic stroke associated with severe hypertension, J. Kanazawa. Med. Univ., 35:166171, 2010.

0370B004

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

Case Reports
0370D001

K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, J.
Kanazawa. Med. Univ., 35:13-15, 2010.

0370D002

K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypernatremia, rhabdomyolysis and acute renal failure, J. Kanazawa. Med. Univ., 35:68-69, 2010.

Others
0370F001

R.Chen, F.Liang, K.Ishigami, T.Kanda, L.Zeng, A.Saito, M.Hasegawa, N.Yamashita, T.Itoh, T.Kigoshi, Y.Izumi,
N.Takekoshi, S.Morimoto: Clinical risk factors in regional brain ischemia using single photon emission computed
tomography, J. Am. Geriatr. Soc., 58：1411-1412, 2010.

Presentations at Conference
International Conference (Presentations)
0370I001

K.Iwai, K.Yanagida, Ｍ.Atsumi, Ｈ.Yano, K.Nomura, J.Sakai, H.Murai, T.Nakahashi, H.Tsuchiya, S.Morimoto:
Anthihypertensive therapy induced transient coma in patient with severe stenosis of the common carotid arteries,
14th International Congress of Endocrinology(ICE2010), (Kyoto, '10.03)，14th International Congress of
Endocrinology(ICE2010) Endocrine Journal Program & Abstracts, 57(Suppl.2):S568, 2010.

0370I002

M.Okuro, K.Tabuchi, TC.Sudhof, S.Nishino: Deficiency of synaptic cell-adhesion molecule, neurexin-3, and wakepromoting response to amphetamine, 24th Associated Professional Sleep Societies, (San Antonio, '10.06)，SLEEP
2010 24th Annual of the Associated Professional Sleep Societies Abstract, 33：A46 (Suppl.), 2010.

0370I003

H.Murai, T.Nakahashi, H.Nakamura, W.Arayama, T.Higashikawa, M.Atsumi, K.Iwai, S.Morimoto: The advantage ofhigh-salt tube mutriton for the elderly patients with acute disease, 32nd ESPEN Congress, (Nice-France, '10.09)，
Abstracts of the32nd ESPEN Congress, 5：ABS-296(Suppl.), 2010.

－ 54 －

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology.

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology.

Senior Assistant Professor

ITO Masatsune

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism.

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology.

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology.

Senior Assistant Professor

FUJIKI Takuma

Pediatric nephrology.

Assistant Professor

AKITA Chisato

Pediatric cardiology.

Assistant Professor

YAMAMURA Junichi

Assistant Professor

SATO Hitoshi

Assistant Professor

OKADA Naoki

Assistant Professor

HIRAMATSU Masayuki Pediatric allergy, Pediatric immunology.

Assistant Professor

HORISAWA Torou

Pediatric hematology, Pediatric oncology.

Assistant Professor

KITAOKA Chika

Pediatric cardiology.

Research Doctor

KITO Toshiyuki

Pediatric allergy, Pediatric immunology.

Research Doctor

YAMAMOTO Akiko

Child neurology.

Peditric Psychosomatic Disorder, Infectious Disease of Childhood,
Clinical Virology, Fast and Easy Detection System for
Infectiousagent.
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism.
Pediatric hematology, Pediatric oncology.

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(K.Yamaji), T.Okamoto, S.Yokota, A.Watanabe, Y.Horikoshi, K.Asami, A.Kikuta, N.Hyakuna, Y.Saikawa,
J.Ueyama, T.Watanabe, M.Okada, T.Taga, H.Kanegane, K.Kogawa, M.Chin, A.Iwai, T.Matsushita, Y.Shimomura,T.Hori, M.Tsurusawa: Minimal residual disease-based augmented therapy in childhood acute lymphoblastic
leukemia: A report from the Japanese childhood cancer and leukemia study group, Pediatr Blood Cancer, 55:12871295, 2010.

－ 55 －

0380B002(T.Taga), Y.Shimomura, T.Hori, Y.Horikoshi, A.Ogawa, M.Itoh, A.Watanabe, Y.Saikawa, J.Ueyama, N.Hyakuna,
M.Chin, S.Iizuka, M.Miyake, A.Iwai, A.Kamitamari, H.Kanegane, N.Sato, M.Tsurusawa: A Morphology-BasedApproach for the Treatment of Children with Acute Myeloid Leukemia: A Report from the Japanese Children’s
Cancer and Leukemia Study Group AML 9805 Study, The Japanese Journal of Pediatric Hematology, 24:283-291,
2010.

0380B003(K.Hirono), N.Yoshimura, M.Taguchi, K.Watanabe, T.Nakamura, F.Ichida, T.Miyawaki: Bosentan induces clinicaland hemodynamic improvement in candidates for right-sided heart bypass surgery, J. Thorac. Cardiovasc. Surg.,
140:346-351, 2010.

0380B004(Y.Ikawa), N.Sugimoto, S.Koizumi, A.Yachie, Y.Saikawa: Dense methylation of types 1 and 2 regulatory regions of
the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene, J. Pediatr. Hematol.
Oncol., 32:4-10, 2010.

Case Reports
0380D001

C.Akita, T.Nakamura: Extrahepatic portosystemic venous shunt presenting as galactosaemia, Pediatr. Radiol.,
40:1300, 2010.

Presentations at Conference
International Conference (Presentations)
0380I001

T.Akita, J.Yokote, C.Akita, T.Nakamura: Surgical simulation of complex congenital heart defects by CARTO XP
Navigation system, The 3rd Congress of Asia-Pachific Pediatric Cardiac Society, (Urayasu, '10.07).

0380I002

M.Ito, H.Sato, A.Yamamoto, H.Kakinuma, Y.Saikawa: High serum lactic acid levels as a new biological marker inpatients with monocarboxylate transporter 8 deficiencies, Annual Symposium of the Society for the Study of Inborn
Errors of Metabolism, (Istanbul, '10.08)

0380I003

T.Akai, H.Iizuka, S.Siraga, Y.Sasagawa, S.Kawakami, Y.Saikawa: Referral pattern of craniosynostosis paien-Is it
early enough?, 38th Annual meeting of the internaional sociey for pediatric neurosurgery, (Korea, '10.10).

－ 56 －

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology.

Professor

KUBOTA Takashi

Schizophrenia, Psychopharmacology, Epilepsy.

Senior Assistant Professor

IWASAKI Shinzo

Psycho Physiology, Neuropsy Chology, Brain Imaging.

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology.

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology.

Senior Assistant Professor

MONKAWA Akikazu

Brain imaging, Schizophrenia.

Senior Assistant Professor

MONKAWA Tomomi

Psychopharmacology, Neuropsychology.

Assistant Professor

KOIZUMI Hazuki

Clinical Psychology, Cognitive-behaviora ltherapy.

Assistant Professor

KOSEKI Yojyu

Brain imaging.

Assistant Professor

SHIMIZU Satoru

Brain imaging.

Assistant Professor

MASUDA Shinji

Schizophrenia.

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI—application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Originals
0390B001(X.Li), S.Shimizu, I.Jibiki, K.Watanabe, T.Kubota: Correlations between Z-scores of VSRAD and regional cerebral
blood flow of SPECT in patients with Alzheimer´s disease and mild cognitive impairment, Psychiatry Clin.
Neurosci., 64:284-292, 2010.

0390B002

M.Sho: Effects of risperidone and blonanserin on excitatory synaptic transmission,and dopamine and serotoninlevels in the hippocampus in rabbits, J. Kanazawa. Med. Univ., 35：77-88, 2010 (in Japanese) .

0390B003

H.Koizumi: Functional magnetic resonance imaging study of neuronal activation during cognitive tasks related tofrontal lobe functions in patients with obsessive-compulsive disorder, J. Kanazawa. Med. Univ., 35:187-195, 2010
(in Japanese) .

－ 57 －

Others
0390F001

S.Shimizu, K.Watanabe, I.Jibiki: Auditory hallucinations associated with clinical dosage of paroxetine:a case report,
Psychiatry Clin. Neurosci., 64:666-667, 2010.

Presentations at Conference
International Conference (Presentations)
0390I001

H.Koizumi, R.Hashimoto: Functional magnetic resonance imaging study of neuronal activation during cognitive
tasks related to frontal lobe functions in patients with obsessive-during cognitive tasks related to frontal lobe
functions in patients with obsessive-compulsive disorder, European Association for Behavioural and Cognitive
Therapies, (Milano, '10.10).

－ 58 －

0400

Department of Diagnostic and Therapeutic Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis.

Professor

WATANABE Naoto

Nuclear Medicine.

Associate Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging.

Associate Professor

TANIGUCHI Mitsuru

Cardiac Nuclear Medicine.

Senior AssistantProfessor(Additional Post)

KUGINUKI Yasuaki

Diagnostic Imaging.

Assistant Professor

KONDO Tamaki

Diagnostic Imaging.

Assistant Professor

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging.

Assistant Professor

KITADATE Masataka Diagnostic Imaging.

Assistant Professor

DOAI Mariko

Diagnostic Imaging.

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging.

Assistant
Professor(Additional Post)OOTA Kiyotaka

Radiation Therapy.

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjögren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

L.Zhang, K.Higashi, Y.Ishigaki, Y.Ueda, T.Sakuma, T.Takegami, M.Oguchi, K.Xu, Y.Ohta, H.Nishida, H.Tonami:
Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as
biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma, Ann. Nucl.
Med., 24:533-540, 2010.

0400B002

M.Matoba, T.Kondo, T.Tanaka, M.Kitadate, K.Oota, H.Tonami: Noninvasive monitoring of radiation-induced early
therapeutic response using high-resolution MR imaging and proton MR spectroscopy in VX2 carcinoma, J. Radiat.
Res., 51:699-705, 2010.

0400B003

Y.Kuginuki: Usefulness of hepatic ADC measured using 3T-MRI in evaluation of liver fibrosis, J. Kanazawa. Med.
Univ., 35:178-186, 2010 (in Japanese) .

－ 59 －

Case Reports
0400D001

M.Matoba, K.Oota, H.Tonami, Y.Masaki, T.Sakai, H.Umehara: Palliative radiotherapy with 1 x 8 Gy using
conformal radiotherapy for chemotherapy-refractory, recurrent, aggressive lymphomas, Jpn. J. Radiol., 28:220223, 2010.

－ 60 －

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery.

Professor

SHIKATA Hiroo

Vascular surgery.

Associate Professor

MORIOKA Koichi

Cardiovascular surgery.

Senior Assistant Professor

KOBATA Takashi

Vascular surgery.

Senior Assistant Professor

YOKOTE Jun

Cardiovascular surgery.

Assistant Professor

NISHIZAWA Hisateru Cardiovascular surgery.

Assistant Professor

NONAKA Toshimichi

Cardiovascular surgery.

Assistant Professor

KIYOSAWA Jun

Cardiovascular surgery.

Assistant Professor

NOGUCHI Yasuhisa

Cardiovascular surgery.

Assistant Professor

MIZUNO Fumito

Cardiovascular surgery.

Assistant Professor

MIKAMI Naofusa

Cardiovascular surgery.

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of tailor-made cardiac reshaping net for heart failure patients
3.Endovascular stent-grafting for aortic aneurysm
4.Minimally invasive catheter ablation for varicose vein

Publications
Originals
0410B001(H.Shigematsu), T.Nishibe, Y.Obitsu, K.Matsuzaki, A.Ishida, T.Miyata, S.Shindo, K.Hida, T.Ohta, M.Ando,
T.Kawasaki, T.Yasugi, T.Matsumoto: Three-year cardiovascular events and disease progress in patients with
peripheral arterial disease: results from the Japan Medication Therapy for Peripheral Arterial Disease(JMETHOD), Int Angiol., 29:2-13, 2010.

Presentations at Conference
International Conference (Presentations)
0410I001

T.Akita, J.Yokote, C.Akita, T.Nakamura: Surgical simulation of complex congenital heart defects by CARTO XP
Navigation system, The 3rd Congress of Asia-Pachific Pediatric Cardiac Society, (Urayasu, '10.07).

－ 61 －

0660

Department of Respirology (Thoracic Surgery)

Faculty
Title

Name

Field of Specialization

Professor

SAKUMA Tsutomu

Professor

SAGAWA Motoyasu

Associate Professor

USUDA Katsuo

Senior Assistant Professor

AIKAWA Hirokazu

thoracic surgery, lung cancer, video assisted thoracoscopic surgery.

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation.

Assistant Professor

UENO Masakatsu

thoracic surgery, lung cancer, pulmonary circulation.

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation.

thoracic surgery, lung cancer, video assisted thoracoscopic surgery,pulmonary edema.
thoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening.
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology.

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy－ 62 －

Publications
Originals
0660B001

L.Zhang, K.Higashi, Y.Ishigaki, Y.Ueda, T.Sakuma, T.Takegami, M.Oguchi, K.Xu, Y.Ohta, H.Nishida, H.Tonami:
Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as
biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma, Ann. Nucl.
Med., 24:533-540, 2010.

0660B002

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, Xi.Zhao, Y.Ueda, K.Higashi, T.Sakuma:
Correlation between glucose transporter-1 expression and 18F-fluoro-2-deoxyglucose uptake on positron emission
tomography in lung cancer, Gen. Thorac. Cardiovasc. Surg., 58:405-410, 2010.

0660B003

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsucihara, K.Nakagawa, T.Sakuma: Lidocaine
administration on the throat under amnesia improves patient satisfaction in flexible bronchoscopy, The Journal of
the Japan Society for Respiratory Endoscopy, 32:409-415, 2010.

0660B004

K.Usuda, M.Sagawa, H.Aikawa, M.Ueno, M.Tanaka, Y.Machida, K.Tsuchihara, K.Nakagawa, T.Sakuma: Midazolam
for sedation in bronchoscopic examination -a questionnaire on patient satisfaction-, The Journal of the Japan
Society for Respiratory Endoscopy, 32:133-137, 2010 (in Japanese) .

Reviews
0660C001(C.Hamashima), D.Aoki, E.Miyagi, E.Saito, T.Nakayama, M.Sagawa, H.Saito, T.Sobue: The Japanese guideline for
cervical cancer screening, Jpn. J. Clin. Oncol., 30:2-18, 2010.

0660C002

M.Sagawa, K.Usuda, H.Aikawa, M.Ueno, Y.Machida, M.Tanaka, T.Sakuma: Personalized medicine for non-small
cell lung cancer, J. Kanazawa. Med. Univ., 35:9-12, 2010 (in Japanese) .

0660C003

Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami,
S.Katsuda: Aquaporin as a novel player in cancer cell the invasion of cancer cells, J. Kanazawa. Med. Univ.,
35:55-60, 2010 (in Japanese) .

Case Reports
0660D001

M.Ueno, K.Usuda, M.Sagawa, M.Tanaka, H.Aikawa, T.Sakuma: Surgical treatment of metastatic malignant solitary
fibrous tumor: a case report, The Journal of the Japanese Association for Chest Surgery, 24:225-228, 2010 (inJapanese) .

Short Communications
0660E001

K.Usuda, M.Sagawa, H.Aikawa, M.Tanaka, Y.Machida, M.Ueno, T.Sakuma: Do Japanese thoracic surgeons thinkthat dissection of the pulmonary ligament is necessary after an upper lobectomy?, Surg Today, 40:1097-1099,
2010.

Presentations at Conference
International Conference (Presentations)
0660I001

Y.Machida, Y.Ueda, M.Shimasaki, M.Sato, M.Sagawa, S.Katsuda, T.Sakuma: Relationship of auaporin 1,3 and 5
expression levels in non-neoplastic lung tissue to cellular differentiation, invasive growth and metastasis potential,
ATS 2010 International canference, (New Orleans, '10.05).

－ 63 －

0420

Department of Surgical Oncology

Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer.

Professor

NOGUCHI Masakuni

Surgery of breast cancer.

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer.

Associate Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease.

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer.

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer.

Senior Assistant Professor

YOSHITANI Shinichiro Surgery of colorectal cancer.

Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer.

Assistant Professor

YOKOI Miki

Surgery of breast cancer.

Assistant Professor

HOSOKAWA Kenzo

Surgery of digestive diseases.

Faculty

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics

Outline of Research・ A treatment strategy for advanced pancreato-biliary cancer, based on the pattern of tumor invasion
・ Investigation concerning laparoscopic surgical procedure for safe and secure operation, and its establishment.
・ Study of generalization and standardization for laparoscopic surgery in the gastrointestinal disease.
・ Study of safeness in the laparoscopic surgery for malignant disease and functional preserving laparoscopic operation.
・ Study on the education and training for laparoscopic surgery.
・ Introduction of the recently evolving engineering and robotics to laparoscopic surgery.

Publications
Originals
0420B001

M.Noguchi, M.Yokoi, Y.Nakano: Axillary reverse mapping with indocyanine fluorescence imaging in patients withbreast cancer, J. Surg. Oncol., 101:217-221, 2010.

0420B002(A.Motoyoshi), M.Noguchi, M.Earashi, Y.Zen, H.Fujii: Histopathological and immunohistochemical evaluations ofbreast cancer treated with radiofrequency ablation, J. Surg. Oncol., 102:385-391, 2010.

0420B003

N.Ueda, T.Kosaka: Optimal lymphadenectomy in advanced gallbladder cancer -From experience of authors-,
Journal of Japanese College of Surgeons, 35:516-522, 2010 (in Japanese) .

Reviews
0420C001

M.Noguchi: Axillary reverse mapping for breast cancer, Breast Cancer Res. Treat., 119:529-535, 2010.

－ 64 －

Case Reports
0420D002

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy, 37:1341-1344, 2010 (in Japanese) .

0420D003(A.Nakanishi), M.Urade, S.Sasaki, T.Nakano, N.Ueda: A case report of chemoradiotherapy with novails andgemcitabine for advanced unresectable pancreatic cancer and postoperative recurrence, Journal of JapaneseCollege of Surgeons, 35:647-652, 2010 (in Japanese) .

0420D004

S.Yoshitani, T.Ohnishi, Y.Tomita, Y.Ohno, K.Hosokawa, M.Yokoi, H.Funaki, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: A case report of pathologically complete response with chemo-radiation for rectal cancer,
Cancer & chemotherapy, 37:2632-2634, 2010 (in Japanese) .

0420D005

H.Funaki, T.Ohnishi, Y.Ohno, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: A case of AGC with pCR after preoperative chemotherapy including S-1 plus cisplatin,
Cancer & chemotherapy, 37:2430-2432, 2010 (in Japanese) .

0420D006

S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki,
T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi: A case ob jejunal GIST diagnosed by double-baloon endoscopy,
Endosc. Forum digest. dis., 26:44-49, 2010 (in Japanese) .

Others
0420F001

M.Noguchi: Axillary reverse mapping for preventing lymphedema in axillary lymph node dissection and/or sentinel
lymph node biopsy, Breast Cancer, 17:155-157, 2010.

Presentations at Conference
International Conference (Presentations)
0420I001

S.Yoshitani, K.Hosokawa, T.Kosaka: Identification of risk factors for stage Ⅱ colorectal cancer in patients withrecurrence, XXIV ISUCRS Biennial Congress, (Seoul, '10.03)，XXIV ISUCRS Biennial Congress Abstracr Book,
233-234, 2010.

0420I002

T.Kosaka, Y.Tomita, T.Onishi, Y.Ono, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, S.Kinami, K.Omote,
N.Ueda, Y.Nakano: Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced
gastric cancer, The 17th Czech-Japan Surgical Symposium, (Kanazawa, '10.06).

0420I003

K.Omote, S.Kinami, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda, Y.Nakano, T.Kosaka: Laparoscopic
surgery for early gastric cancer -Experience in our institute-, The 17th Czech-Japan Surgical Symposium,(Kanazawa, '10.06).

0420I004

S.Kinami, T.Kosaka, S.Yoshitani, K.Omote, N.Ueda, Y.Nakano, S.Fushida, T.Fujimura, T.Ohta: The clinicaladvantage of the sentinel node biopsy for early gastric cancer in conducting the pylorus preserving procedure, The
17th Czech-Japan Surgical Symposium, (Kanazawa, '10.06).

0420I005

K.Omote, S.Kinami, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda, Y.Nakano, T.Kosaka: Laparoscopic
surgery for early gastric cancer, ESMO conference: 12th World congress on gastrointestinal cancer, (Barcelona,'10.06)，Annals of Oncology, 21 suppl.6: vi88, 2010.

0420I006

T.Kosaka, K.Hosokawa, M.Yokoi, S.Kinami, K.Omote: Neoadjuvant chemotherapy with a combination of S-1 andcisplatin in nonresectable advanced gastric cancer: A short communication, ESMO conference: 12th World
congress on gastrointestinal cancer, (Barcelona, '10.06)，Annals of Oncology, 21 supple.6:vi117, 2010.

0420I007

T.Kosaka, S.Kinami, K.Omote, M.Yokoi: Prognostic significance of nutritional factors in curatively resected gastriccancer patients, 21st Meeting of the European Association for Cancer Research, (Oslo, '10.06)，EJC Supplements,
8:154, 2010.

－ 65 －

0420I008

K.Omote, S.Kinami, T.Ohnishi, Y.Tomita, Y.Ohno, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda,
Y.Nakano, T.Kosaka: Laparoscopic gastrectomy for early gastric cancer, 9th International Conference of the Asian
Clinical Oncology Society, (Gifu, '10.08).

0420I009

H.Funaki, T.Ohnishi, Y.Ohno, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: Pathological complete response in advanced gastric cancer Stage IV after preoperative
chemotherapy including S-1 plus Cisplatin -- Report of a case, 9th International Conference of the Asian ClinicalOncology Society, (Gifu, '10.08).

0420I010

S.Kinami, T.Kosaka, T.Onishi, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, K.Omote, N.Ueda, Y.Nakano: The
application of Liga-Sure precise to the lymph node dissection in gastric cancer surgery, 9th International
Conference of the Asian Clinical Oncology Society, (Gifu, '10.08).

0420I011

M.Yokoi, Y.Ohno, Y.Nakano, T.Kosaka, M.Noguchi: A Novel Technique for Breast-concerving Surgery, The 3rdInternational Oncoplastic Breast Surgery Symposium 2010, (Tokyo, '10.11).

－ 66 －

0430

Department of Orthopedics Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery.

Professor

KAWAHARA Norio

Spinal surgery.

Professor(Additional Post)

OKADA Masato

Peripheral nerve surgery, Trauma.

Associate Professor

FUJITA Takuya

Spinal surgery.

Associate Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine.

Senior Assistant Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine.

Senior Assistant Professor

OKUDA Tetsuhito

Spinal surgery.

Senior Assistant Professor

MAEOKA Hayato

Trauma.

Senior Assistant Professor

ICHISEKI Toru

Hip surgery.

Assistant Professor

HOSOKAWA Hidetaka Spinal surgery.

Assistant Professor

HATANO Eijyu

Spinal surgery.

Assistant Professor

MIAKI Kohei

Hip surgery.

Assistant Professor

HIROMURA Kentaro

Trauma.

Assistant Professor

YASUDA Yoshihito

Spinal surgery.

Assistant Professor

FUKUI Kiyokazu

Hip surgery.

Assistant Professor

KITAMURA Kenji

Hip surgery.

Assistant Professor

TAKADA Naruki

Trauma.

Assistant Professor

TOMIDOKORO Jun

Hip Surgery.

Research Doctor

AKAGAWA Makoto

orthopaedic surgery.

Research Doctor

ORITA Yugo

orthopaedic surgery.

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, we have been trying to elucidate the mechanism of degeneration of lumber disc. It has been reported that
apoptosis of vertebral disc cells occurs in the degenerative intervertebral disc. However, its molecular mechanism remains
to be defined. The gene expression of Bax and Bcl-2 was analyzed in degenerative intervertebral disc. As a result,mechanical stress of the disc induces apoptosis through a Bax, reducing the number of cells and the synthesis of－ 67 －

extracelular matrix proteins and resulting in the degeneration of the disc.

Publications
Originals
0430B001(Y.Takatori), K.Ito, M.Sofue, Y.Hirota, M.Itoman, T.Matsumoto, Y.Hamada, H.Shindo, H.Yamada, Y.Yasunaga,
H.Ito, S.Mori, I.Owan, G.Fujii, H.Ohashi, T.Mawatari, T.Iga, N.Takahira, T.Sugimori, H.Sugiyama, K.Okano,
T.Karita, K.Ando, T.Hamaki, T.Hirayama, K.Iwata, M.Matsuura, S.Jingushi: Analysis of interobserver reliability forradiographic staging of coxarthrosis and indexes of acetabular dysplasia: a preliminary study, J. Orthop. Sci.,
15:14-19, 2010.

0430B002(M.Sakaguchi), T.Tanaka, W.Fukushima, T.Kubo, Y.Hirota, A.Kaneuji, T.Matsumoto, (Idiopathic ONF Multicenter
Case-Control Study Group): Impact of oral corticosteroid use for idiopathic osteonecrosis of the femoral head: anationwide multicenter case-control study in Japan, J. Orthop. Sci., 15:185-191, 2010.

0430B003

T.Mikami, T.Ichiseki, A.Kaneuji, Y.Ueda, T.Sugimori, K.Fukui, T.Matsumoto: Prevention of steroid-induced
osteonecrosis by intravenous administration of vitamin E in a rabbit model, J. Orthop. Sci., 15:674-677, 2010.

0430B004(S.Jingushi), S.Ohfuji, M.Sofue, Y.Hirota, M.Itoman, T.Matsumoto, Y.Hamada, H.Shindo, Y.Takatori, H.Yamada,
Y.Yasunaga, H.Ito, S.Mori, I.Owan, G.Fujii, H.Ohashi, Y.Iwamoto, K.Miyanishi, T.Iga, N.Takahira, T.Sugimori,
H.Sugiyama, K.Okano, T.Karita, K.Ando, T.Hamaki, T.Hirayama, K.Iwata, S.Nakasone, M.Matsuura,T.Mawatari:Multiinstitutional epidemiological study regarding osteoarthritis of the hip in Japan, J. Orthop. Sci., 15:626-631,
2010.

0430B007

M.Okada, E.Hatano, K.Hiromura, H.Maeoka, T.Matsumoto: Clinical results of the displased intra-articularcalcaneal fractures treated by open reduction and internal fixation, The Journal of the Japanese Society for Surgeryof the Foot, 31:117-121, 2010 (in Japanese) .

0430B008

T.Fujita, T.Okuda, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: Clinical outcome of posterior cervicaldecompression using a tubular retractor for cervical radiculopathy with a minimum follow-up of 2 years, J SpineRes., 1:1507-1511, 2010 (in Japanese) .

0430B015

T.Okuda, T.Fujita, A.Kaneuji, E.Hatano, T.Ichiseki, Y.Yasuda, K.Fukui, T.Matsumoto: Incidence of spondylolysis,
spondylolisthesis and degenerative scoliosis of the lumbar spine in patients with terminal stage hip osteoarthritis, J
Spine Res., 1:1964-1967, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0430I001

T.Okuda, T.Fujita, H.Hosokawa, E.Hatano, Y.Yasuda, T.Matsumoto: Relationship between cage position and discangle at the fused level in posterior lumbar interbody fusion, Argospine 2010 Symposium, (Paris, '10.01).

0430I002

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: A radiological study on the true anatomical position of
the acetabulum in Japanese adult females, The 20th Japanese-Korean Combined Orthopaedic Symposium (JKCOS
2010), (Ibusuki, '10.06)，The 20th Japanese-Korean Combined Orthopaedic Symposium Program & Abstracts, 142,
2010.

0430I003

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: A radiological study on the center of the hip in
acetabular dysplasia, 14eme Reunion de Societe Franco-Japonaise d'Orthopedie, (Hiroshima, '10.09).

0430I004

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto: Isolated acetabular revision without removal of thewellfixed uncemented stem for early return to society, 85e SOFCOT(Societe Francaise de Chirurgie Orthopediqueet Traumatologique), (Paris, '10.11).

－ 68 －

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease.

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor.

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease.

Associate Professor

TAKADA Hisashi

crebrovascular disease, head injury, interventional neurosurgery.

Senior Assistant Professor

IIDA Takaaki

spinal disease, peripheral nerve disease.

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery.

Assistant Professor

SASAGAWA Yasuo

brain tumor.

Assistant Professor

SIRAGA Syunsuke

general neurosurgery.

Assistant Professor

YAMAMOTO Jiro

general neurosurgery.

Assistant Professor

TORIGOE Keiichiro

general neurosurgery.

Research Doctor

TSUKADA Tsuyoshi

general neurosurgery.

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma－ 69 －

5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

Publications
Originals
0440B001(H.Shima), M.Hasegawa, O.Tachibana, M.Nomura, J.Yamashita, Y.Ozaki, J.Kawai, M.Higuchi, H.Kado: Oculardominance affects magnitude of dipole moment: an MEG study, Neuroreport., 21:817-821, 2010.

Case Reports
0440D001

M.Nakanishi, M.Kaito, Y.Gondo, H.Takada, M.Matsui, G.Hirose: Moyamoya disease presenting with an acuteconfusional state in an elderly patient, J. Stroke Cerebrovasc. Dis., 247-250, 2010.

Presentations at Conference
International Conference (Presentations)
0440I001

O.Tachibana, Y.Sasagawa, K.Torigoe, S.Siraga, K.Yamamoto, K.Okamoto, T.Iida, T.Akai, H.Iizuka, A.Nakagawa,D.Koya: Inflammatory cytokines from Rathke cleft cysts are possible inducers of secondary hypophysitis, 14th
International Congress of Endocrinology, (Kyoto, '10.03)，Endocrine Jounal (14th International Congress of
Endocrinology Program & Abstracts), 57(Suppl.2):S507, 2010.

0440I002

O.Tachibana, Y.Sasagawa, K.Torigoe, K.Yamamoto, S.Siraga, K.Okamoto, T.Akai, H.Iizuka, A.Nakagawa, D.Koya:
Expression of interleukin-1 β, interleukin-6, interleukin-12p40 and TNF α in human Rathke cleft cysts-A
possible inducer of secondary hypophysitis associated with Rathke clef cyst-, 14th International Congress of
Endocrinology, (Kyoto, '10.03).

0440I003

T.Akai, H.Iizuka, S.Siraga, Y.Sasagawa, S.Kawakami, Y.Saikawa: Referral pattern of craniosynostosis paien-Is it
early enough?, 38th Annual meeting of the internaional sociey for pediatric neurosurgery, (Korea, '10.10).

－ 70 －

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery.

Senior Assistant Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery.

Senior Assistant Professor

MORITA Reiji

Plastic and Reconstructive Surgery.

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery.

Senior Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery.

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery.

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery.

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery.

Assistant Professor

NISHIO Akiko

Plastic and Reconstructive Surgery.

Assistant Professor

TAGUCHI Rie

Plastic and Reconstructive Surgery.

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery.

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery.

Assistant Professor

KOMURO Akito

Plastic and Reconstructive Surgery.

Researcher

QUAN Liangliang

Plastic and Reconstructive Surgery.

Keywords of Researchfibroblasts, FGF recptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocytes, wound healing, craniofacial
surgery, zygoma, cleft lip, clept palate, microtia, tissue expansion, crainofacial cleft, orbital advancement, microsurgery,free flap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in cougenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process
are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials
are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

－ 71 －

Publications
Originals
0450B001

L.Quan, R.Morita, S.Kawakami: Toxic shock syndrome toxin-1(TSST-1)antibody levels in Japanese childen, Burns,
36:716-721, 2010.

0450B002

N.Koizumi: Basic fibroblast growth factor stimulates proliferation and differentiation of perichondrocytes of rabbit
auricular cartilage in Vivo, J. Kanazawa. Med. Univ., 35:122-130, 2010 (in Japanese) .

Reviews
0450C002

Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami,
S.Katsuda: Aquaporin as a novel player in cancer cell the invasion of cancer cells, J. Kanazawa. Med. Univ.,
35:55-60, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0450I001

H.Daizo, M.Yamashita, M.Kishibe, K.Shimada, S.Kawakami: Surgical outcome of five cases denunstrating fibrous
dysplasia in the craniofacial lesion, The 10th Korea-Japan Cingress of Plastic and Reconstructive Surgery, (Korea,'10.06).

0450I002

Y.Himi, N.Koizumi, S.Kawakami: Proliferative and differentiative effects of basic Fibroblast Growth
Factor(bFGF)on the elastic cartilage in rabbit ear, The 10th Korea-Japan Cingress of Plastic and Reconstructive
Surgery, (Korea, '10.06).

0450I003

M.Kishibe, S.Kawakami: An anatomical study of mimic muscles and facial nerve: Dissection from the deep surface,the 20th China-Japan Joint Congress on Plastic Surgery, (Shanghai, '10.08).

0450I004

R.Morita, M.Yamashita, M.Kishibe, K.Shimada, S.Kawakami: Sentinel navigation surgery with combination methodwith dye and radioisotopes for malignant melanoma and non-melanoma cutaneous malignancies, the 20th ChinaJapan Joint Congress on Plastic Surgery, (Shanghai, '10.08).

0450I005

M.Kadohira, T.Kurosawa, M.Yamashita, M.Kishibe, K.Shimada, S.Kawakami: Clinical investigations of the caseswith macrostomia in Kanazawa medical university hospital, the 20th China-Japan Joint Congress on Plastic
Surgery, (Shanghai, '10.08).

0450I006

A.Komuro, N.Koizumi, R.Morita, S.Kawakami: An 11-year experience in the surgical management, the 20th ChinaJapan Joint Congress on Plastic Surgery, (Shanghai, '10.08).

0450I007

T.Akai, H.Iizuka, S.Siraga, Y.Sasagawa, S.Kawakami, Y.Saikawa: Referral pattern of craniosynostosis paien-Is it
early enough?, 38th Annual meeting of the internaional sociey for pediatric neurosurgery, (Korea, '10.10).

－ 72 －

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Senior Assistant Professor

MASUYAMA Hiroaki

Pediatric surgery, Liver transplantation

Assistant Professor

OSHIKIRI Takahiro

Pediatric surgery

Assistant Professor

YASUI Yoshitomo

Pediatric surgery.

Research Doctor

KUWAHARA Tsuyoshi Pediatric surgery.

Research Doctor

TAKAHASHI
Sadayoshi

Faculty

Pediatric surgery

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

M.Kohno, H.Ikawa, T.Kuwahara, S.Takahashi, Y.Yasui, T.Oshikiri, H.Masuyama: The postoperative bowel function
with transanal endorectal pull-through and transabdominal procedure (Z-shaped anastomosis) for Hirschsprung's
disease, J. Kanazawa. Med. Univ., 35:1-8, 2010 (in Japanese) .

Case Reports
0460D001

M.Kohno, H.Ikawa, K.Konuma, H.Masuyama, H.Fukumoto, E.Ogawa, S.Takahashi, N.Kurose: Laparoscopic
enucleation of a gastroenteric duplication cyst arising in a pancreatic tail that did not communicate with thepancreatic duct: report of a case, Surg Today, 40:81-284, 2010.

0460D002

H.Minato, S.Kaji, E.Kinoshita, N.Kurose, T.Nojima, M.Kohno, K.Konuma, H.Ikawa: Solitary intrapulmonary cystic
lymphangioma in an infant: A case report with literature review, Pathol. Res. Pract., 206:851-856, 2010.

－ 73 －

Presentations at Conference
International Conference (Synposium)
0460H001

H.Masuyama, H.Ikawa, T.Kuwahara, S.Takahashi, H.Fukumoto, M.Kohno: Is transanal endorectal pull throughbeneficial for colonic motility defecation?, XXIII International Symposium on Paediatric Surgical Research, (Tokyo,'10.09).

International Conference (Presentations)
0460I001

M.Kohno, H.Ikawa, K.Konuma, H.Masuyama, T.Oshikiri, S.Takahashi, T.Kuwahara: Extended perineal
anorectoplasty to avoid damaging the rectal branch of pelvic plexus of imperforate anus with rectoprostatic urethral
fistula, 43rd Pacific Association of Pediatric Surgeons, (Kobe, '10.04).

0460I002

H.Masuyama, H.Ikawa, T.Kuwahara, S.Takahashi, H.Fukumoto, M.Kohno: Minimal damage to rectal branches ofPelvic Plexus during surgery can achieve good postoperative colonic motility after transanal endorectal pullthrough(TAEPT)for Hirschsprung's disease, 43rd Pacific Assosiation of Pediatric Surgeons, (Kobe, '10.04).

－ 74 －

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis.

Professor

KITAGAWA Kazuko

Associate
Professor(Additional Post)

KOJIMA Masami

Senior Assistant Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration.

Senior Assistant Professor

SAKAMOTO Yasuo

ophthalmological optics.

Senior Assistant Professor

NAGAI Kota

cataract, epidemiology,

Senior Assistant Professor

KAWAKAMI Yutaka

cataract, thyroid ocular.

Assistant Professor

FUJITA Nobuyuki

uveitis.

Assistant Professor

YAGUCHI Hiromoto

corneal epithelium, glsucoma.

Assistant Professor

HAGIWARA Kenta

ocular infection.

Assistant Professor

INAGAKI Shinsuke

ocular infection.

Assistant Professor

OSADA Hiromi

cataract, ophthalmology.

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology.

Research Associate

HATSUSAKA Natsuko ophthalmological optics.

ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics.
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

Keywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland and China). These studies have included prevalence, incidence and risk
factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we have worked onimage analysis of the crystalline lens, drew up a new classification system for cataract, and done research on visualperformance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using animalmodels and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative drug for
PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

－ 75 －

Publications
Originals
0470B001(JP.Whitcher), CH.Shiboski, SC.Shiboski, AM.Heidenreich, K.Kitagawa, S.Zhang, S.Hamann, G.Larkin,
NA.Mcnamara, JS.Greenspan, TE.Daniels: A simplified quantitative method for assessing keratoconjunctivitis siccafrom the Sjogren's syndrome international registry, Am. J. Ophthalmol., 149:405-415, 2010.

0470B002

J.Qu, H.Sasaki, Y.Sakamoto, Y.Kawakami, K.Sasaki, F.Jonasson: Higher-order ocular aberrations caused by
crystalline lens waterclefts, J. Cataract Refract. Surg., 36:799-805, 2010.

0470B003(A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara: Acute dosimetry and estimationof threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, IEEE Trans.
Microw. Theory Tech., 57:1234-1242, 2010.

0470B004(A.Arnarsson), F.Jonasson, KF.Damji, MS.Gottfredsdottir, T.Sverrisson, H.Sasaki: Exfoliation syndrome in the
Reykjavik eye study : risk factors for baseline prevalence and 5-year incidence, Br. J. Ophthalmol., 94:831-835,
2010.

0470B005

Y.Oikawa, A.Kobayashi, K.kitagawa: Anti-acanthamoeba efficacy in pimaricine (natamycin) whici is antimycotic
drug, Ann. rep. Ohara Hosp., 50：27-30, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0470I001

M.Kojima, Y.Yamashiro, T.Sasaki, Y.Suzuki, K.Sasaki, H.Sasaki: Analysis of heat transportation to crystalline lenssurface by aqueous aqueous humor convection, The Association for Research in Vision and Ophthalmology,(Florida, '10.05).

0470I002(T.Tarura), K.Sasaki, Y.Sakamoto, N.Hatsusaka, D.Lom, HM.Cheng, F.Jonasson, H.Sasaki: A comparison ofocular sturcture and optical systems in eyes of middle-aged Taiwanese and Icelanders, The Association for
Research in Vision and Ophthalmology, (Florida, '10.05).

0470I003

H.Sasaki, N.Mita, Y.Sakamoto, E.Shibuya, N.Hatsusaka, F.Jonasson, K.Sasaki: Verification of predictive accuracyof index of lens transparency using a Scheimpflug camera and 12-year follow-up, The Association for Research invision and Ophthalmology, (Florida, '10.05).

0470I004

M.Fukuda, H.Sasaki, K.Kitagawa, A.Kawai, Y.Seki, M.Yoshikawa: Comparison of degree of penetration of βbiocker ophthalmic solution with and without preservative into rabbit aqueous humor, The association for Researchin Vision and Ophthalmology, (Florida, '10.05).

0470I005

N.Hatsusaka, Y.Sakamoto, N.Mita, E.Shibuya, J.Qu, H.Sasaki: Relationship of axial length to myopic influence on
nuclear cataract, The Association for Research in vision and Ophthalmology, (Florida, '10.05).

0470I006

N.Shibata, K.Kitagawa, Y.Sakamoto, Y.Yamashiro, N.Fujita, N.Hatsusaka, H.Sasaki: Changes in corneal higher
order aberration after pterygium excision, The Association for Research in Vision and Ophthalmology, (Florida,'10.05).

0470I007

Y.Yamashiro, K.Sato, A.Hirata, M.Kojima, T.Sakai, S.Watanabe, M.Taki, Y.Suzuki, K.Sasaki, H.Sasaki: Normalized
temperature elevation velocity in ocular tissues by 18-40 GHz radio-frequency exposure, The Association for
Research in Vision and Ophthalmology, (Florida, '10.05).

0470I008

Y.Sakamoto, N.Hatsusaka, E.Shibuya, N.Mita, J.Qu, H.Sasaki, H.Nakaizumi, K.Sasaki: Deterioration nquality ofvision by nono-opaque watercleft lens defects, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0470I009

H.Osada, Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, N.Hatsusaka, M.Tarura, Y.Kawakami, J.Qu, HM.Cheng,
K.Sasaki, H.Sasaki: Prevalence of cataract in anurban region of Taiwan comparison with three different areas in
China and an area in Japan, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

－ 76 －

0470I010

M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki: Examination of threshold 60 Ghz Millimeter wave ocular exposure in
rabbit, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0470I011

N.Hatsusaka, Y.Sakamoto, E.Shibuya, N.Mita, Y.Kawakami, N.Fujita, H.Osada, S.Inagaki, N.Shibata, H.Sasaki:
Refractive power of nuclear cataract eyes and influence on myopia, The 8th Asian Cataract Research Conference,(Hangzhou, '10.06).

0470I012

N.Mita, N.Hatsusaka, E.Shibuya, Y.Sakamoto, F.Jonasson, K.Sasaki, H.Sasaki: Prediction of aging change in lensof normal Icelanders Reykjavik eye Study, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0470I013

E.Shibuya, J.Qu, Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, F.Jonasson, K.Sasaki, H.Sasaki: Natural course ofcortical opacity over 12 years Reykjavik Eye study, The 8th Asian Cataract Research Conference, (Hangzhou,'10.06).

0470I014(Y.Suzuki), M.Kojima, T.Sakai, Y.Yamashiro, T.Taguchi, A.Koike, M.Taki, K.Sasaki, H.Sasaki: Experimental anal
ysis on the thermal convection of aqueous humor in anterior chamber driven by the millimrter-wave exposure at
77GHZ, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

0470I015

M.Kojima, S.Taiji, Y.Yamashiro, Y.Suzuki, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki: Mechanism of ocularthmperature difference between 18 and 40 HGZ exposure, The Bioelectromagnetics Society 32nd annual Meeting,(Seoul, '10.06).

0470I016

Y.Yamashiro, A.Hirata, K.Sato, M.Kojima, T.Sakai, S.Watanabe, K.Wake, M.Taki, Y.Suzuki, Y.Kamimura,
Y.Sakamoto, Y.Kawakami, K.Sasaki, H.Sasaki: Comparison of temperature in ocular tissues by 18-40 GHZ radiofrequency exposure, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

0470I017(A.Koike), Y.Suzuki, T.Taguchi, M.Kojima, Y.Yamashiro, T.Sakai, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Velocimetry on thermal convection flow of aqueous humor in anterior chamber caused by millimeter-wave
exposure, 2010 Asis-Pacific Radio Science Congerence, (Toyama, '10.09).

0470I018

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki,
M.Taki: Verification of sagety guidelines for 60 GHz millimeter wave ocular exposure, 2010 Asis-Pacific Radio
Science Congerence, (Toyama, '10.09).

－ 77 －

0480

Department of Otolaryngology

Faculty
Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology,Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Audiology, Equiribrium, Neuro-otology, phonation, Medical
education

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

HORIGUCHI Akiko

Equilibrium, Vestibular research, Laryngology, Voice restration

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Assistant Professor

MIYAZAWA Toru

Head and neck oncology, Head and neck surgery

Assistant Professor

YAMADA Kanako

Rhinology

Assistant Professor

SAKAI Aya

Sleep apnea syndrome

Assistant Professor

KITAMURA Miwa

Pediatric otology, Pollinosis

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Keywords of Researcholfactory disorders, neurotology, tympanoplasty, cochlear implant, middle ear implant, virtual endoscopy, computer-aided
surgery, endoscopic nasal surgery, laser surgery, sleep apnea & snoar surgery, skull base surgery, head and neck tumor
surgery, molecular biology, oncology, laryngology, speech rehabilitation, acoustic neuroma surgery, navigation surgery,tele-medicine, thyroid tumor surgery, virtual education for surgery

Outline of Research
Basic and clinical research for the diagnosis and treatment of olfactory disorders
Central mechanism of auduological function by MEG
Clinical research for Head and Neck tumor and Oncology
Restration for phonation with Provox 2 prosthesis
Research for Thyroid and parathyroid gland
Clinical reserach for snoar and sleep apnea

Publications
Originals
0480B002(T.Tsukatani), T.Miwa, T.Yoshizaki: Nasal fracture reduction using ultrasonography, Pract. otol., 103:813-818,
2010 (in Japanese) .

Reviews
0480C015

T.Miwa: Recent progress of basic research on olfactory reception and the pathology of olfactory disorders, Pract.
otol., 103:1073-1081, 2010 (in Japanese) .

－ 78 －

Case Reports
0480D002

A.Sakai, H.Ishimasa, H.Tsuji: A case of cystic hygroma in the parotid gland of an adult, Journal of Japan Societyfor Head and Neck Surgery, 20:69-74, 2010 (in Japanese) .

0480D003

K.Yamada, H.Shiga, J.Yamamoto, T.Miwa: A case of recurrent frontal sinusitis -The usefulness of Mini-Trephine-,
Oto-rhino-laryngology Tokyo, 53:327-330, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0480I001

T.Miwa, H.Shiga, J.Taki, S.Kinuya, K.Washiyama: Olfactory scintigraphy in normal volunteer by intranasal Tl-201
administration, ACHEMS 2010 Annual Meeting, (San Francisco, '10.04).

0480I002

H.Shiga, A.Tsuchida, K.Washiyama, J.Yamamoto, S.Yagi, T.Yoshizaki, M.Furukawa, R.Amano, T.Miwa:
Regeneration of olfactory nerve is accelerated by oral intake of TJ-137 (Chinese medicine; Kamikihitou) in vivo,
The 29th International Symposium on Infection and Allergy of the Nose, (Geneva, '10.06).

0480I003

H.Shiga, J.Taki, S.Kinuya, M.Furukawa, T.Miwa: Thallium olfacto-scintigraphy visualizes nasal transport to theolfactory bulb, The 29th International Symposium on Infection and Allergy of the Nose, (Geneva, '10.06).

0480I004

A.Sakai, T.Miwa: Selection of Treatment for Obstructive Sleep Apnea Syndrome Based on Dynamic MRI Scanning,
The 7th International Symposium of Tonsils and Mucosal Barriers of the Upper Airways, (Asahikawa, '10.07).

－ 79 －

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis.

Associate Professor

TANABE Hiroshi

Medical mycology, Decubitns.

Associate Professor

KAWASAKI Masako

Medical mycology.

Associate Professor

NISHIBU Akiko

Immunology.

Senior Assistant Professor

WATANABE Seiji

Medical mycology.

Senior Assistant Professor

ABE Shinya

Skin tumor and growth factores.

Senior Assistant Professor

FUJII Toshiki

Dermatopathology.

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor.

Assistant Professor

TAKEDA Kiminobu

Medical mycology.

Assistant Professor

FUJITA Jun

Medical mycology.

Assistant Professor

HASEI Maki

Skin tumor and growth factores, Medical mycology.

Assistant Professor

ANZAWA Kazushi

Medical mycology.

Research Doctor

YOSHIMURA Rieko

Medical mycology.

Research Doctor

HATTA Jyunko

Image analysis.

Research Doctor

NANBU Masayuki

Dermatopathology.

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, phylogeny, taxonomy, molecular epidemiology, molecular typing, electron
microscopy, dermatopathology, skin tumor, decubitus, immunopathology, immunology, langerhans cell

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Books
0490A003

T.Mochizuki: Fungal Infections, Therapy of Skin Diseases (In Krieg T, Bickers D, Miyachi Y (Eds), 149-156,
Springer-Verlag, Berlin Heidelberg Germany, 2010.

－ 80 －

Publications
Originals
0490B001
0490B002(S.Watanabe), T.Harada, M.Hiruma, K.Iozumi, T.Katoh, T.Mochizuki, W.Naka: Epidemiological survey of footdiseases in Japan: Results of 30 000 foot checks by dermatologists, J. Dermatol., 37:397-406, 2010.
K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Successful mating of Trichophyton rubrum with Arthroderma

simii, Med. Mycol., 48:629-634, 2010.
0490B003

A.Wakasa, K.Anzawa, M.Kawasaki, T.Mochizuki: Molecular typing of Trichophyton mentagrophytes var.
interdigitale isolated in a university hospital in Japan based on the non-transcribed spacer region of the ribosomal
RNA gene, J. Dermatol., 37:431-440, 2010.

0490B004(M.Yanagihara), M.Kawasaki, H.Ishizaki, K.Anzawa, S.Udagawa, T.Mochizuki, Y.Sato, N.Tachikawa, H.Hanakawa:Tiny keratotic brown lesions on the interdigital web between the toes of a healthy man caused by Curvularia
species infection and a review of cutaneous Curvularia infections, Mycoscience., 51:224-233, 2010.

0490B005

M.Kawasaki, K.Anzawa, A.Wakasa, K.Takeda, T.Mochizuki, H.Ishizaki, B.Hemashettar: Matings among threeteleomorphs of Trichophyton mentagrophytes, Jpn. J. Med. Mycol., 51:143-152, 2010.

Case Reports
0490D001

0490D003

K.Takeda, J.Fujita, T.Fujii, H.Tanabe, T.Mochizuki, M.Yanagihara: Case of remitting seronegative symmetricalsynovitis with pitting edema (RS3PE syndrome) showing dermatomyositis-like eruption, J. Dermatol., 37:102-106,
2010.
M.Nanbu, T.Fujii, S.Abe, M.Kawasaki, T.Mochizuki: Cutaneous phaeohyphomycosis Caused by Exophiala

jeanselmei, Skin research, 9:173-179, 2010 (in Japanese) .
0490D004

T.Sakamoto, T.Ushigami, K.Anzawa, T.Fujii, S.Abe, T.Mochizuki, Y.Hayashi: A Case of Sporotrichosis Promptly
Diagnosed by Direct PCR, Skin research, 9:254-259, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0490I001

M.Kawasaki, K.Anzawa, A.Nishibu, H.Tanabe, H.Ishizaki, T.Mochizuki: Mating behavior and phylogenetic
incongruity among Trichophyton and Arthroderma species, 9th International Mycological Congress, IMC9: Thebiology of fungi, (Edinburgh, '10.08).

0490I002

K.Takeda, A.Nishibu, H.Tanabe, K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Twenty three cases of tinea
capitis at the Kanazawa Medical University Hospital, The First Eastern Asia Dermatology Congress, (Fukuoka,'10.09).

－ 81 －

0500

Department of Urogenital Surgery

Title

Name

Field of Specialization

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Associate Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Senior Assistant Professor

KAWAMURA Kenjikidney stone disease, urogenital cancer

Senior Assistant Professor

MORIYAMA Manabu

kidney transplantation， kidney stone disease

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

CHIKAZAWA Ippei

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

ISHII Takeo

general urology

Assistant Professor

MORITA Nobuyo

general urology

Faculty

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence

Outline of Researchclinical research on renal transplantation, mechanism of urolithiasis

Publications
Originals
0500B001

M.Moriyama, T.Tanaka, N.Morita, T.Ishii, I.Chikazawa, K.Suga, K.Miyazawa, K.Suzuki: Renal protective effects oferythropoietin on ischemic reperfusion injury, Cell Transplant., 19:713-721, 2010.

0500B002

T.Tanaka, N.Morita, T.Ishii, H.Tachibana, K.Tokunaga, I.Chikazawa, K.Suga, M.Moriyama, K.Miyazawa, K.Suzuki:
Cadaveric kidney donation from non-heart beating donor and deceased donor kidney transplantation in kanazawa
medical university hospital, J. Kanazawa. Med. Univ., 35:55-60, 2010 (in Japanese) .

0500B003

M.Moriyama, T.Tanaka, K.Suzuki: Renal protective effects of erythropoietin on ischemic reperfusion injury, Acta
Urol. Jpn., 56:473-479, 2010 (in Japanese) .

Case Reports
0500D001

H.Atsumi, M.Asaka, S.Kimura, J.Imura, K.Fujimoto, Y.Chikazawa, M.Nakagawa, H.Okuyama, H.Yamaya,
M.Moriyama, T.Tanaka, K.Suzuki, H.Yokoyama: A case of second renal transplantation with acute antibodymediated rejection complicated with BK virus nephropathy, Clin. Transplant., 24:35-38, 2010.

－ 82 －

Others
0500F002

T.Tanaka, S.Takahara: Marginal－Donor and Recipient－, Acta Urol. Jpn., 56：467-468, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0500I001

M.Moriyama: Renal protective effects of erythropoiesis stimulation agent on ischemic reperfusion injury, XXIIIInternational Congress of the Transplantation Society, (Vancouver, '10.08).

－ 83 －

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Professor

MAKINODA Satoru

Associate Professor

Field of Specialization

reproductive physiology, perinatal medicine, gynecologic oncology,
ovulation and cytokines.
Gynecologic Pathology, Tumor Virology, Sexually Transmitted
SASAGAWA Toshiyuki
Infection Research, Immunology.

Associate
Professor(Additional Post)

FUJII Ryota

perinatal medicine, reproductive endocrinology.

Senior Assistant Professor

WATANABE Yukio

perinatal medicine, reproductive endocrinology, perinatal diagnosis.

Senior Assistant Professor

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology.

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine.

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology.

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine.

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine.

Assistant Professor

SASAKURA Chihaya

perinatal medicine, perinatal diagnosis.

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine.

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

－ 84 －

Presentations at Conference
International Conference (Presentations)
0510I001

S.Makinoda: Ninety percents of LUF during clomiphene-hCG treatment can be prevented by using G-CSF, 26th
Annual Meeting of European Society of Human Reproduction and Embryology, (Rome, '10.06).

0510I002

R.Fujii: Possible Involvement of Interleukin-6 in Human Luteolysis, 26th Annual Meeting of European Society of
Human Reproduction and Embryology, (Rome, '10.06).

0510I003

T.Sasagawa, Md. Mosfequr Rahman, H.Tomizawa, S.Fujita, H.Takagi, Y.Oka, R.Fujii, S.Makinoda: A novel ablative
therapy using phenol for cervical intraepithelial lesions and condyloma acuminata, 26th International Papillomavirus
Conference, (Montreal, '10.07).

0510I004(F.Ito), K.Ideta, T.Irie, T.Sasagawa: Multi-center study onhuman papillomavirus associated diseases in Japan (JHERS), 26th International Papillomavirus Conferemce, (Montreal, '10.07).

0510I005

H.Tomizawa, S.Fujita, Y.Oka, H.Takagi, T.Wasada, R.Fujii, T.Sasagawa, S.Makinoda: Novel treatment for
Luteinized Unruptured Follicle (LUF) using GranulocyteColony-Stimulating Factor (G-CSF), 20th Worl Congress
on Fertility and Sterility, (Munich, '10.09).

0510I006

T.Wasada, Y.Oka, S.Makinoda: Myometrial blood flow analysis in pregnant women with IUGR, 20th World
Congress on Ultrasound in Obstetrics and Gynecology, (Prague, '10.10).

0510I007

Y.Oka, T.Wasada, S.Makinoda: The usefulness of MRI in the diagnosis of fetal lung maturity, 20th World Congress
on Ultrasound in Obstetrics and Gynecology, (Prague, '10.10).

0510I008

T.Sasagawa: Novel immunology-bosed therapies for HPV-related cervical neoplasia, 9th International Workshop
Immunotherapy 2010, (Havana, '10.11).

－ 85 －

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics.

Senior Assistant Professor

SHIRAISHI Miharu

Clinical anesthesia, Pain medicine, Palliative medicine.

Assistant Professor

NISHIIKE Satoshi

Clinical anesthesia, Nerve block, Vascular reactivity.

Assistant Professor

SUGIURA Soichiro

Clinical anesthesia, Intensive care medicine, Vascular reactivity.

Assistant Professor

HORIUCHI Katsura

Clinical anesthesia, Intensive care medicine.

Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, Shock.

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine.

Assistant Professor

MAGARA Ayuko

Clinical anesthesia, Palliative medicine.

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia.

Assistant Professor

MURATA Yuriko

Clinical anesthesia.

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity.

Assistant Professor

BEN Asami

Clinical anesthesia.

Assistant Professor

YUGI Haruka

Clinical anesthesia.

Assistant Professor

TANAKA Yasunori

Clinical anesthesia.

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, paraquat, sepsis, delayed neuronal death, apoptosis, inducible nitric oxide synthase, brainischemia, epidural blockade, cytochrome P-450, liver mitochondoria, nitric oxide, hypothermia

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined 1) the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole, and 2) the effects of transient forebrain ischemia on
apoptotic death of the hippocampal pyramidal neuron in Mongolian gerbil.

Publications
Short Communications
0520E001

H.Kida, S.Nishiike, S.Sugiura, M.Shiraishi, H.Tsuchida: Anesthetic management for posterior spinal fusion in apatient with ankylosing sopndylitis and osteoporosis, The Japanese journal of anesthesiology, 59:390-392, 2010 (inJapanese) .

－ 86 －

Others
0520F002

S.Sugiura, M.Shiraishi, S.Nishiike, K.Horiuchi, H.Kida, Y.Yamaoka, A.Magara, A.Hiramatsu, Y.Murata,
T.Hiramatsu, A.Ben, Y.Tanaka, H.Yugi, H.Tsuchida: Anesthesia for one-lung ventilation, Journal of clinicalanesthesia, 34：1029-1033, 2010 (in Japanese) .

－ 87 －

0650

Department of Rehabilitation Medicine

Faculty
Title

Name

Professor

KAGECHIKA Kenji

Senior AssistantProfessor(Additional Post)

NAKATA Minori

Field of Specialization
rehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction.
Treatment and rehabilitation of musculoskeletal disorders, caused bywork-related、whiplash-injury-associated, and other origins.

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0650B001(N.Kalezic), Y.Noborisaka, M.Nakata, A.G.Crenshaw, S.Karlsson, E.Lyskov, P.O.Eriksson: Cardiovascular andmuscle activity during chewing in whiplash-associated disorders (WAD), Arch. Oral Biol., 55:447-453, 2010.

Presentations at Conference
International Conference (Presentations)
0650I001

M.Nakata, M.Yoshizawa, Y.Yamada, K.Kagechika, P.O.Eriksson: Pressure pain thresholds at different body regionsin chronic musculoskeletal disorders(MSD) vs healthy, Seventh International Conference on Prevention of WorkRelated Musculoskeletal Disorders, (Angers, '10.08).

－ 88 －

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine.

Associate Professor

OGURA Kenichi

Emergency, Neurosurgery.

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis.

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery.

Assistant Professor

MORITA Hideki

Emergency.

Assistant Professor

GOTO Tetsuro

Emergency.

Assistant Professor

MIZUNUMA Mariko

Emergency.

Research Doctor

IWAI Junichi

Emergency.

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

Presentations at Conference
International Conference (Synposium)
0550H001

Y.Watoh: A line-up of earthquake-related diseases-in causl and temporal classification-, Mizunami International
Symposium on Earthquake Casualties and Health Consequences, (Mizunami, '10.11).

International Conference (Presentations)
0550I001

J.Iwai, A.Watanabe, M.Mizunuma, T.Goto, H.Morita, K.Murasaka, S.Mashiba, K.Ogura, Y.Watoh: A trial andevaluation of the physician-driven ambulance for five years, The 10th Asia Pacific Conference on Disaster
Medicine, (Sapporo, '10.08)，10th APCDM, 138, 2010.

0550I002

K.Ogura, S.Mashiba, A.Watanabe, J.Iwai, M.Mizunuma, T.Goto, H.Morita, K.Murasaka, Y.Watoh: Comparativeevaluation of the two DMAT's response, The 10th Asia Pacific Conference on Disaster Medicine, (Sapporo,'10.08)，10th APCDM, 206, 2010.

－ 89 －

0570

District medical

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase.

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A Kampo medicine, boiogito,
inhibits obesity in ovariectomized rats, Evid Based Complement Alternat Med, 7:87-95, 2010.

0570B002

R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda: The effects of a
PPARα agonist on myocardial damage in obese diabetic mice with heart failure, Int. Heart J., 51:199-206, 2010.

0570B003

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

Case Reports
0570D001

K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, J.
Kanazawa. Med. Univ., 35:13-15, 2010.

0570D002

K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypernatremia, rhabdomyolysis and acute renal failure, J. Kanazawa. Med. Univ., 35:68-69, 2010.

－ 90 －

0530

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery.

Associate Professor

YOSHMURA Hiroshi

temporomandibular joint disorders, stomatology, neuroscience.

Associate Professor

DEMURA Noboru

orthodontics, stomatology.

Senior Assistant Professor

KANEYAMA Keisekioral cancer, stomatology, oral and maxillofacial surgery, orthognathic
surgery.

Senior Assistant Professor

AOKI Hideaki

Rehabilitation Medicine, Oral and Maxillofacial Surgery.

Senior Assistant Professor

ONO Tohru

oral and maxillofacial surgery, oral infection, temporomandibular joint
disorders, oral oncology, dental implant.

Assistant Professor

TAKAHASHI Motohiro temporomandibular joint disorders, stomatology.

Assistant Professor

HONJOU Miho

Orthodontics.

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery

Outline of Research
1. Basic and clinical research for disorders of temporomandibular
joints.
2. Molecular biological research for growth and metastasis oftumors in oral region.
3. Pathophysiological research for abnormal development of oral andmaxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central
nervous systems.

Publications
Originals
0530B001

H.Yoshimura, T.Sugai, M.Honjo, K.Kaneyama, N.Segami, N.Kato: Application of caffeine reveals input frequencydependent determination of signal-traveling routes between primary and secondary visual cortices in rats,
Neurosci. Res., 66:30-36, 2010.

0530B002

K.Kaneyama, N.Segami, H.Yoshmura, M.Honjo, N.Demura: Increased levels of soluble cytokine receptors in the
synovial fluid of temporomandibular joint disorders in relation to joint effusion on magnetic resonance images, J.
Oral Maxillofac. Surg., 68:1088-1093, 2010.

0530B003

H.Yoshimura, S.Morimoto, M.Okuro, N.Segami, N.Kato: Evaluations of dementia by EEG frequency analysis andpsychological examination, J. Physiol. Sci., 60:383-388, 2010.

－ 91 －

Presentations at Conference
International Conference (Presentations)
0530I001

N.Segami: Eminectomy with/without high condylectomy under local anesthesia for habitual dislocation of the TMJ,
20th Congress of the european association for cranio-maxillofacial surgery, (Bruges, '10.09).

0530I002

H.Aoki: Dysfunction of auditory tube after lower jaw surgery, AAO-HNSF annual meeting 2010, (Boston, '10.09).

－ 92 －

School of Nursing

8010

Basic Nursing

Faculty
Title

Name

Field of Specialization

Associate Professor

SAKAI Keiko

Proficiency and stressor of teachers in nursing.

Senior Assistant Professor

SAKAI Keiko

Communication Skills.

Assistant Professor

KIMOTO Miki

Experiences of diabetic patients that hemodialysis begins hold family's
desire.

Assistant Professor

KYUJI Kazuyo

Nursing Students and Proffessional Sprit.

Keywords of Researchteachers in nursing, ｐroficiency, stressor, sleep apnea syndrome, QOL, bi-cultural nursing, feelings and QOL, siniorsitizen, care-house

Outline of Research
1. Feelings and QOL of sinior sitizuns living care-house run by a manicipal government or private sector.
2. Proficiency and stressor of teachers in nursing.
3. Quality of life of persons with sleep apnea syndrome.

－ 93 －

8030

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Field of Specialization

Professor

KITAOKA Kazuyo

Occupational Mental Health, Job Stress, Burnout, Rehabilitation of
People with Mental Disability.

Assistant Professor

NAGAI Makie

Occupational Mental Health.

Keywords of Researchoccupational health, occupational mental health, job stress, burnout, the Maslach Burnout Inventory, MBI, rehabilitation,
mental disability

Outline of Research
The major research theme is 'Occupational Mental Health' and 'Rehabilitation of People with Mental Disability'. We've
been doing the burnout study for banishing it. The professor has published the Japanese version of the Maslach Burnout
Inventory (MBI), global scale for measure of burnout. We also put our effort to seek the methodology to support thosepeople with mental disabiltiy.

Publications
Originals
8030B001(K.Ohnishi), Y.Ohgushi, M.Nakano, H.Fujii, H.Tanaka, K.Kitaoka, J.Nakahara, Y.Narita: Moral distressexperienced by psychiatric nurses in Japan, Nurs Ethics., 17:726-740, 2010.

8030B002

M.Nagai, K.Kitaoka: Components of learning of nursing students in simulation as psychiatric outpatients, Journal ofJapan Academy of Psychiatric and Mental Health Nursing, 19:128-136, 2010 (in Japanese) .

8030B003(R.Baba), T.Sasahara, K.Kitaoka, M.Umeuchi, Y.Kizawa: Palliative care certified nurses' job satisfaction, burnout
and related factors, Palliative Care Res., 5:127-136, 2010 (in Japanese) .

Presentations at Conference
International Conference (Synposium)
8030H001

K.Kitaoka: Burnout among nurses in Japan, The International Academic Symposium of the110th Anniversary
Celebration of Tongi Hospital, (Wuhan, '10.10).

International Conference (Presentations)
8030I001(S.Kendall), K.Kitaoka, F.Ochiai, A.Tsuda, M.Nagai, M.Uchida, T.Hashimoto: A comparative study of the effect ofgroup based parenting support on parental stress and outcomes for children in both the UK and Japan, The Going
Global 4 Conference, (London, '10.03).

8030I002

K.Kitaoka, M.Nagai, H.Nakagawa, S.Masuda, K.Ogino: Burnout levelo of the Japanese working population, ICOHN& ACOHN Joint Conference 2010, (Yokohama, '10.08).

－ 94 －

8040

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Sachiko

Nephrology Nursing, Transplant Nursing.

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

HIRAYAMA Emiko

Nursing Ethics, Medical Ethics, Caring.

Assistant Professor

UCHIDA Maki

Cancer Nursing, Terminal Care.

Assistant Professor

KITAMURA Yoshiko

Cancer Nursing.

Assistant Professor

YAMAZAKI Matsumi

Therapeutic Exercise in patients with Chronic Disease.

Keywords of Research
Nephrology Nursing, Transplant Nursing, Cronic Disease Nursing, Terminal Care, Cancer Nursing, Nursing Ethics, Woundcare, Stoma care, Continence care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8040B001

M.Yamazaki, M.Inagaki: Mechanisms involved the continuation of exercise in patients with type2 diabetes mellitus,
Journal of Japanese Society of Nursing Research, 33:41-50, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8040I001(S.Kendall), K.Kitaoka, F.Ochiai, A.Tsuda, M.Nagai, M.Uchida, T.Hashimoto: A comparative study of the effect ofgroup based parenting support on parental stress and outcomes for children in both the UK and Japan, The Going
Global 4 Conference, (London, '10.03).

8040I002(M. Ueta), C.Konya, J. Sugama, T. Nakatani, M. Okuwa, J. Matsuo, S. Fukuda, M. Dai, H. Sanada:
Ultrasonographic evaluation of unusual periwound tissues of pressure ulcers, WOCN/WCET Joint Conference,(Phoenix, Arizona, '10.06)，J Wound Ostomy Continence Nurs., 2010;37(3):s124, 2010.

8040I003(S. Iizaka), G. Nakagami, M. Ueta, J. Matsuo, C.Konya, J. Sugama, T. Nagase, H. Sanada: Association between
granulation tissue color and nutritional status in patients with pressure ulcers : development of a quantitative
indicator by digital image analysis, WOCN/WCET Joint Conference, (Phoenix, Arizona, '10.06)，J Wound Ostomy
Continence Nurs., 37(3):s129, 2010.

－ 95 －

8050

Nursing of the Elderly

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKAYAMA Naoko

community/elderly nursing science.

Senior Assistant Professor

KOIZUMI Yumi

community/elderly nursing science.

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science.

Keywords of Research
Nursing of the Elderly

Outline of Research
Verification of Nursing Care about Daily living activities and their communication of the elderly with Dementia,also,theeffectiveness of the elderly Dementia prevention on the basis Local residents.
The Study of General Principle of Florence Nightingale connected with Nurse's recognition and expression in Nursing
phenomenon.

Publications
Originals
8050B001

M.Atsumi, Y.Koizumi, K.Ishigami, K.Satoh, O.Iritani, M.Okuro, S.Morimoto: Increased level of LDL cholesterol inelderly patients with acute ischemic stroke associated with severe hypertension, J. Kanazawa. Med. Univ., 35:166171, 2010.

Presentations at Conference
International Conference (Presentations)
8050I001(S.Kendall), K.Kitaoka, F.Ochiai, A.Tsuda, M.Nagai, M.Uchida, T.Hashimoto: A comparative study of the effect ofgroup based parenting support on parental stress and outcomes for children in both the UK and Japan, The Going
Global 4 Conference, (London, '10.03).

－ 96 －

8060

Child Nursing

Faculty
Title

Name

Field of Specialization

Associate Professor

TSUDA Akiko

Pediatric Nursing.

Assistant Professor

TERAI Takahiro

Pediatric Nursing.

Keywords of Researchchild, parenting, parenting support, attachment, daily living life, biological rhythm

Outline of Research
The study on biological rhythm and life style in childhood.

Presentations at Conference
International Conference (Presentations)
8060I001(S.Kendall), K.Kitaoka, F.Ochiai, A.Tsuda, M.Nagai, M.Uchida, T.Hashimoto: A comparative study of the effect ofgroup based parenting support on parental stress and outcomes for children in both the UK and Japan, The Going
Global 4 Conference, (London, '10.03).

－ 97 －

8070

Maternity Nursing

Faculty
Title

Name

Field of Specialization

Professor

OCHIAI Fumie

Maternity Health, Child Health, Midwifery.

Associate Professor

SASANO Kyoko

Crinical nursing, Nursing education.

Assistant Professor

TSUBOMOTO Takiko Maternity Nursing.

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing.

Research Associate

YORITSUNE Kaoru

Life development nursing.

Keywords of Research
Practice, Pregnancy, Midwife, "Maternity Nursing, perinatal", after childbirth, breastfeeding, parenting stress maternity
Nursing, Mother and child nursing, Child care, Mother, Mother-child relation

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8070B001(Y.Shimizu), S.Sekimizu, T.Endo, F.Ochiai: Mothers'childcare happiness－Influence of employment status onmothers'happiness in child care－, Japanese Journal of Maternal Health, 51:367-375, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8070I001(S.Kendall), K.Kitaoka, F.Ochiai, A.Tsuda, M.Nagai, M.Uchida, T.Hashimoto: A comparative study of the effect ofgroup based parenting support on parental stress and outcomes for children in both the UK and Japan, The Going
Global 4 Conference, (London, '10.03).

－ 98 －

8080

Community Nursing

Faculty
Title

Name

Field of Specialization

Professor

FUKUMA Kazumi

Community Health Nursing.

Senior Assistant Professor

SAKURAI Shihomi

Community Health Nursing.

Assistant Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse.

Keywords of Researchcommunity nursing-care activity, community nursing education, Health promotion, successful aging, activity of cmmunity
organization

Outline of Research
We aim at the research of community nursing that contributes to sustain and improve quality of life and health of people inthe community. We have been studying about community nursing-care activity, community nursing education, Healthpromotion, successful aging and elder abuse

Presentations at Conference
International Conference (Presentations)
8080I001

Yuko Hamazaki: Investigation of what the nursing students have learnt from the narrative of intractable disease
patient in the participating class, 2nd Japan china Nursing Conferene abstract journal, (Tokyo, '10.10)－ 99 －

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

KATO Kinko

Home Care Nursing, Public Health Nursing, Psychiatric Mental
Health Nursing in Community.

Senior Assistant Professor

MAEDA Shukohome care, home health care nurse.

Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
support.

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program

Outline of Research
Practice and restructuring of the infection control edcation program for home visiting nurses－ 100 －

8100

Human Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology.

Professor

OKADA Masato

Peripheral nerve surgery, Trauma.

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology.

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine.

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology.

Associate Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature.

Associate Professor

HONDA Ryumon

Environment and health, Epidemiology.

Associate Professor

FUJII Ryota

perinatal medicine, reproductive endocrinology.

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Okada/ Calcaneal fracture, M. Okada/
carpal tunnel syndrome, M. Kojima/electromagnetic radiation, M. Kojima/ultraviolet exposure, M. Kojima/infrared rays
exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Okada: Percutaneous osteosynthesis of calcaneal fractures. Endoscopic surgical treatment of carpal tunnel syndrome.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.

Publications
Originals
8100B001(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: Bone resorption
acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure, Toxicol. Mech.
Methods., 20:7-13, 2010.

8100B002

Q.LI, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa:Occupational class and incidence rates of cardiovascular events in middle aged men in Japan, Ind. Health, 48:324330, 2010.

8100B003

M.Nakashima, M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, J. Atheroscler. Thromb., 17:1082-1095, 2010.

8100B004

W.Hirokawa, K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middleaged Japanese men, J. Atheroscler. Thromb., 17:934-943, 2010.

－ 101 －

8100B005

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse, H.Nakagawa:Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged nondiabetic Japanese men, Diabetologia, 53:1894-1902, 2010.

8100B006(A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara: Acute dosimetry and estimationof threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, IEEE Trans.
Microw. Theory Tech., 57:1234-1242, 2010.

8100B007

R.Honda, W.Swaddiwudhipong, M.Nishijo, P.Mahasakpan, W.Teeyakasem, W.Ruangyuttikarn, S.Satarug,
C.Padungtod, H.Nakagawa: Cadmium induced renal dysfunction among residents of rice farming area downstream
from a zinc-mineralized belt in Thailand, Toxicol. Lett., 198:26-32, 2010.

8100B008

R.Chen, F.Liang, S.Morimoto, Q.Li, J.Moriya, J.Yamakawa, T.Takahashi, K.Iwai, T.Kanda: The effects of a
PPARα agonist on myocardial damage in obese diabetic mice with heart failure, Int. Heart J., 51:199-206, 2010.

8100B009(R.Sato), T.Kido, R.Honda, M.Nishijo, H.Nakagawa, E.Kobayashi, Y.Suwazono: Seventeen-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan, Bull. Environ.
Contam. Toxicol., 84:363-367, 2010.

8100B010(I.Ishikawa), S.Hayama, K.Morita, T.Nakazawa, H.Yokoyama, R.Honda, K.Satoh, T.Kakuma: Long-term natural
history of acquired cystic disease of the kidney, Ther Apher Dial, 14:409-416, 2010.

8100B011(W.Swaddiwudhipong), P.Limpatanachote, M.Nishijo, R.Honda, P.Mahasakpan, S.Krintratun: Cadmium-exposed
population in Mae Sot district, Tak province:3. associations between urinary cadmium and renal
dysfunction,hypertension,diabetes, and urinary stones, J. Med. Assoc. Thai., 93:231-238, 2010.

8100B012(P.Limpatanachote), W.Swaddiwudhipong, M.Nishijo, R.Honda, P.Mahasakpan, K.Nambunmee, W.Ruangyuttikarn:
Cadmium-exposed population in Mae Sot district, Tak province: 4 bone mineral density in persons with highcadmium exposure, J. Med. Assoc. Thai., 93:1451-1457, 2010.

8100B013

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

8100B014

M.Okada, E.Hatano, K.Hiromura, H.Maeoka, T.Matsumoto: Clinical results of the displased intra-articularcalcaneal fractures treated by open reduction and internal fixation, The Journal of the Japanese Society for Surgeryof the Foot, 31:117-121, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
8100I001

M.Ishizaki, H.Nakagawa, N.Kawakami, A.Inoue, Y.Morikawa, T.Kido, Y.Yamada: Relationship between job stressand job performance in a factory, The Joint Scientific Meeting of International Epidemiological Association Western
Pacific Region and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of
Epidemiology, 20(Suppl 1):295, 2010.

8100I002

K.Nakamura, W.Hirokawa, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormality and risk of cardiovascular diseases among middle-aged Japanese men,
The Joint Scientific Meeting of International Epidemiological Association Western Pacific Region and 20th Japan
Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology, 20(Suppl 1):191, 2010.

8100I003

M.Sakurai, M.Nakashima, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, The Joint Scientific Meeting of International Epidemiological Association Western PacificRegion and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology,20(Suppl 1):216, 2010.

－ 102 －

8100I004

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse: Association between
long working hours and sleep problems in white-collar workers, The Joint Scientific Meeting of International
Epidemiological Association Western Pacific Region and 20th Japan Epidemiological Association, (Koshigaya,'10.01).

8100I005

K.Iwai, K.Yanagida, Ｍ.Atsumi, Ｈ.Yano, K.Nomura, J.Sakai, H.Murai, T.Nakahashi, H.Tsuchiya, S.Morimoto:
Anthihypertensive therapy induced transient coma in patient with severe stenosis of the common carotid arteries,
14th International Congress of Endocrinology(ICE2010), (Kyoto, '10.03)，14th International Congress of
Endocrinology(ICE2010) Endocrine Journal Program & Abstracts, 57(Suppl.2):S568, 2010.

8100I006

M.Kojima, Y.Yamashiro, T.Sasaki, Y.Suzuki, K.Sasaki, H.Sasaki: Analysis of heat transportation to crystalline lenssurface by aqueous aqueous humor convection, The Association for Research in Vision and Ophthalmology,(Florida, '10.05).

8100I007

Y.Yamashiro, K.Sato, A.Hirata, M.Kojima, T.Sakai, S.Watanabe, M.Taki, Y.Suzuki, K.Sasaki, H.Sasaki: Normalized
temperature elevation velocity in ocular tissues by 18-40 GHz radio-frequency exposure, The Association for
Research in Vision and Ophthalmology, (Florida, '10.05).

8100I008

H.Osada, Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, N.Hatsusaka, M.Tarura, Y.Kawakami, J.Qu, HM.Cheng,
K.Sasaki, H.Sasaki: Prevalence of cataract in anurban region of Taiwan comparison with three different areas in
China and an area in Japan, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

8100I009

M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki: Examination of threshold 60 Ghz Millimeter wave ocular exposure in
rabbit, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

8100I010

E.Shibuya, J.Qu, Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, F.Jonasson, K.Sasaki, H.Sasaki: Natural course ofcortical opacity over 12 years Reykjavik Eye study, The 8th Asian Cataract Research Conference, (Hangzhou,'10.06).

8100I011(Y.Suzuki), M.Kojima, T.Sakai, Y.Yamashiro, T.Taguchi, A.Koike, M.Taki, K.Sasaki, H.Sasaki: Experimental anal
ysis on the thermal convection of aqueous humor in anterior chamber driven by the millimrter-wave exposure at
77GHZ, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

8100I012

Y.Yamashiro, A.Hirata, K.Sato, M.Kojima, T.Sakai, S.Watanabe, K.Wake, M.Taki, Y.Suzuki, Y.Kamimura,
Y.Sakamoto, Y.Kawakami, K.Sasaki, H.Sasaki: Comparison of temperature in ocular tissues by 18-40 GHZ radiofrequency exposure, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

8100I013(A.Koike), Y.Suzuki, T.Taguchi, M.Kojima, Y.Yamashiro, T.Sakai, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Velocimetry on thermal convection flow of aqueous humor in anterior chamber caused by millimeter-wave
exposure, 2010 Asis-Pacific Radio Science Congerence, (Toyama, '10.09).

8100I014

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki,
M.Taki: Verification of sagety guidelines for 60 GHz millimeter wave ocular exposure, 2010 Asis-Pacific Radio
Science Congerence, (Toyama, '10.09).

8100I015

H.Murai, T.Nakahashi, H.Nakamura, W.Arayama, T.Higashikawa, M.Atsumi, K.Iwai, S.Morimoto: The advantage ofhigh-salt tube mutriton for the elderly patients with acute disease, 32nd ESPEN Congress, (Nice-France, '10.09)，
Abstracts of the32nd ESPEN Congress, 5：ABS-296(Suppl.), 2010.

8100I016

M.Nishijo, W.Swaddiwudhipong, K.Nambunmee, W.Ruangyuttikam, R.Honda, Y.Morikawa, H.Nakagawa: Effect of
cadmium on health risk of arterioselerosis; a study of Thai population environmentary exposed to cadmium, 6thconference on molecular mechanisums of metal toxicity and carcinogenesis, (Kentucky, '10.11).

－ 103 －

－ 104 －Liberal Arts

0040

Department of Life Science (Natural Science:Physics)

Faculty
Title

Name

Field of Specialization

Associate Professor

SUGITANI Michio

Oprical imaging of signal propagation in the piriform cortex.

Associate Professor

NAKAMURA Kiyoshi

Study on Physics Education for Medical College, Study on Room
Acoustics.

Keywords of Researchpiriform cortex, signal propagation, physical experiment, demonstration, elementary particle physics, acoustic environment,
optical recording

Outline of Research
Sugitani:Optical imaging of signal propagation in the piriform cortex
Nakamura: In order that the student who majors in life science may deepen an understanding of a lecture, and in order toenable independent learning, we are developing the stude support which used a demonstration experiment and intranet.

－ 105 －

0050

Department of Life Science (Natural Science:Chemistry)

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells.

Keywords of Research
Metastasis, Metastasis Inducing Gene, RhoGDIβ(LyGDI/D4GDI/RhoGDI2)

Outline of Research
Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the activity of Rho family GTPases. Our studies haveindicated that RhoGDIβ(LyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.
Further investigation of the details of RhoGDIβ's role in cancer progression
and metastasis is important. It will lead to a better treatment for cancer.

－ 106 －

0060

Department of Life Science (Natural Science:Biology)

Faculty
Title

Name

Field of Specialization

Professor

HORI Isao

Development of ascidians

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry.

Keywords of Researchplanaria, acoel, regeneration, differentiation, ultrastructure, pharynx, sponge, metamorphosis, immunoelectron microscopy,
neurosynaps, neurosecretory cell, lectin, galectin, β-galactoside, Xenopus, development, placenta, trophoblast

Outline of Research
１）Functional analysis of Galectins, a family of ・-galactosides binding proteins.
a）Roles of Galectins in animal development.
b）Roles of Galectins in the formation of placenta.
c）Regulations of virus growth by Galectins.
２）Electron microscopic analysis of the mechanisms of regeneration of planarians.

－ 107 －

0090

Department of Life Science (Physical Education)

Faculty
Title

Name

Field of Specialization

Professor

TAMURA Nobuki

OtherGraduate School, Division of Physical Recreation.

Associate Professor

UEDA Fumio

Physical strength and a study about the athletic capability, A
basketball competition.

Senior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education.

Keywords of Researchhygiene of exercise, physical fitness, near-infrared spectroscopy, muscle strength, small qroup learning, helth rerated
training, prescribed execise, wheel chair basketball, sports medicine, motor abillty, working skeletal muscle wxygenation,
lower leg, problem learning, effects in iron deficiency, prescription of exercise program, improvement of physical fitness,
physical fitness, exercise prescription, soccer

Outline of Research
Tamura : I do the exercise tolerance test for the people who must attempt the healthy physical fitness. Based on the result,
I make the appropriate prescription in the people and guide them in the motion. After two, four, six and twelve month, I
investigate the effects of the motion. The prescription is made again again, if the good effect by the motion is not obtained.
Ueda : To evaluate the students' physical fitness and healthcondition collectively,Ipractice the physical fitness and the
motor ability test, measure their physique, and understand their condition. Making them as a basis on the guidance ofteaching , I try to promote the students physical fitness and health condition.
Tsuda : Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition, ourresearch focuses on improvememt of physical fitness through soccre for dhildren taing physical education in school.

Publications
Originals
0090B001

R.Tsuda, N.Tamura, F.Ueda: The relationships between habits of exercise, physical fitness, and awareness about
health and physical fitness in students at kanazawa medical university, Mem. Lib. Kanazawa Med. Univ., 38:65-69,
2010 (in Japanese) .

－ 108 －

0010

Department of Human Science (Humanities)

Faculty
Title

Name

Field of Specialization

Professor

HIRAGUCHI Tetsuo

environmental-ethnoarchaeology, peace studies.

Associate Professor

TAKEDA Koichi

Philosophy, History of logic.

Keywords of Researchzoo-archaeology, cetacean, dolphin, whale, faunal remains, environmental archaeology, whaling, ancient diet, Palaeolithic
period, Jomon period, ethno-archaeology, anthropological education, peace study, logic, metaphysics, form, content,
predicate, category, deduction, induction, matter, being, substance, definion

Outline of Research
Hiraguchi:Environmental and ethnological archaeology (especially prehistoric whaling), anthropological education for medical
students, and peace studies.
Takeda:It has been asserted that logic and metaphysics are different to each other in Aristotle because his logic is aorganon of science. However, his logic is the system where reasonings are dependent on the contents of propositions, while
modern formal logic involves abstraction of any content. In Aristotle, Metaphysics studys the order of things which arecontents of logic. From this point, I aim to explicate the relation between logic and metaphysics in Aristotle.

－ 109 －

0030

Department of Human Science (Mathematics)

Faculty
Title

Name

Field of Specialization

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space.

Associate Professor

YOSHINO Kenichi

Algebra theory, number theory.

Keywords of Research
Bertrand curve, Mannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic field,
Mannheim curve, Frenet frame, curvature, Lie group, Lorentzian manifold, harmonic analysis, isometry group, abelian field,
class number parity, cyclotomic unit

Outline of Research
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Yoshino : The determination of class number and the ideal class group of the cyclotomic field－ 110 －

0070

Department of Human Science (Foreign Languages:English)

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics.

Senior Assistant Professor

KAKIZAKI KenichiContemporary Jewish American Authors' Works.

Senior Assistant Professor

BURKE STEVEN
ThomasEnglish.

Senior Assistant Professor

CRAIG Woods

English, Medical English.

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 research, language
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical English

Outline of Research
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here, Japanese) influence the pronunciation ofJapanese speakers of English is studied.
kakizaki: To understand about contemporary American Jewish author and a Nobel laureate, Saul Bellow's idea on thefundamental questions about human existence: "Where are we going? What are we doing here?" To understand his writing
techinique of novels and his idea on the art.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.
Woods:Using computer software for natural language processing of the
English found in medical articles to determine the most commonly used
words, forms and structures.

Publications
Originals
0070B001

K.Kakizaki: The collapse of the self in "The yellow wallpaper", Mem. Lib. Kanazawa Med. Univ., 38:15-25, 2010.

0070B002

K.Kakizaki: Legacy in ravelstein, Mem. Lib. Kanazawa Med. Univ., 38:27-37, 2010.

0070B003

T.Burke steven: Developing and assessing a reading class for medical students, Mem. Lib. Kanazawa Med. Univ.,
38:39-45, 2010.

0070B004

T.Burke steven: A preliminary evaluation of KMU's 2010 California and Hawaii, USA study abroad programs, Mem.
Lib. Kanazawa Med. Univ., 38:47-54, 2010.

0070B005

W.Craig: Checking th Quality of criterion-referenced tests, Mem. Lib. Kanazawa Med. Univ., 38:55-64, 2010.

0070B006

K.Kakizaki: The african american and the jew in Mr.Sammler's planet, J. Engl. Lang. Lit., 58:77-91, 2010.

0070B007

K.Kakizaki: The control of distance in the narration in Mr.Sammler's planet, Kanazawa English Studies, 27:147160, 2010.

－ 111 －

0080

Department of Human Science (Foreign Languages:German)

Faculty
Title

Name

Field of Specialization

Associate Professor

HARA Akira

Austria literature led by Hofmannsthal.

Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung.

Keywords of Researchend of the century, culture, the middle Ages, Modern times, Europe

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century, many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Hälfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen, wie sie der Historiker Reinharｔ Kosellecｋ die „Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte, möchte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen.

Publications
Originals
0080B001

M.Kochi: Wilhelm Mommsen : Die politischen Anschauungen Goethes(4), Mem. Lib. Kanazawa Med. Univ., 38:7188, 2010 (in Japanese) .

－ 112 －

0081

Department of Human Science (Linguistics)

Faculty
Title
Professor

Name

Field of Specialization

AINODA Noriko

How do the Japanese medical students acquire medical terms in
English as a second language? My research focuses on this question
using both linguistic and phonetic knowledge, with the research
evidence in cognitive science.

Keywords of Research
Linguistics, phonetics, English language education, medical education

Outline of Research
Metacognition is an essential factor for lifelong learning of which skills should be fostered during undergraduate medical
education. To seek longitudinal changes in metacognitive processes through problem-based learning (PBL), the year 3
students' reflective comments were categorically analized. The results showed that "knowledge of ignorance," one ofmetacognitive skills, could be fostered in PBL.

－ 113 －

－ 114 －University Hospital

0690

Department of Endoscopy

Faculty
Title

Name

Professor

Field of Specialization

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease.Endoscopical treatment of its disease,especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer.
Diagnosis for esophagus, gastro-intestine, colon, liver & bileduct
URASHIMA Sachio
disease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer.
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer.
Diagnosis for esophagus, gastro-intestine, colon, disease.
KAWAURA Ken
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer.
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer.
ITO Tohru

Associate Professor

Senior Assistant Professor

Assistant Professor

Assistant Professor

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer.
(Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Originals
0690B001

M.Sakuma, S.Matsuba, H.Matsuno, K.Uchikawa, T.Itou, S.Shimizu, N.Yamaguchi: Effect of hot-springhydrotherapy on lymphocyte subsets expressing β２-adrenergic receptors, The Journal of the Japanese Society ofBalneology, 73:101-108, 2010 (in Japanese) .

Presentations at Conference
International Conference (Key Note Lecture)
0690G001

T.Itou: Diagnosis and treatment of early gastric cancer, 10th International Workshop & Symposium on Therapeutic
Endoscopy & Gastroenterology, (Suzhou, '10.06).

－ 115 －

0620

Department of Pathology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

MINATO Hiroshi

Anatomical pathology, Laboratory medicine, Pathological study of
pulmonary and mediastinal lesion, Pathological study of head & necktumor.

KUROSE Nozomu

surgical pathology, molecular pathology

KINOSHITA Erikosurgical pathology, molecular pathology

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
surgical pathology, cytopathology, molecular pathology, ultrastructual pathology, general pathology, clinical pathology,
diagnosis, histochemistry, immunostaining, PCR, in situ hybridization

Outline of Research
1.Anatomical pathology, Laboratory medicine, Pathological study of pulmonary and mediastinal lesion, Pathological study ofhead & neck tumor.
2.cellular pathology.
3.molecular pathology.

Publications
Originals
0620B001(Y.Nakanuma), Y.Zen, K.Harada, M.Sasaki, A.Nonomura, T.Uehara, K.Sano, F.Kondo, T.Fukusato, K.Tsuneyama,
M.Ito, K.Wakasa, M.Nomoto, H.Minato, H.Haga, M.Kage, H.Yano, J.Haratake, S.Aishima, T.Masuda, H.Aoyama,
A.Miyakawa-Hayashino, T.Matsumoto, H.Sanefuji, H.Ojima, T-C.Chen, E.Yu, J-H.Kim, YN.Park, W.Tsui:
Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens:
interobserver agreement, Pathol. Int., 60:167-174, 2010.

Case Reports
0620D001(J.Shimizu), Y.Arano, N.Ishikawa, M.Oda, I.Matsumoto, H.Minato: Clinicopathological study of surgically treatedcases of tracheobronchial adenoid cystic carcinoma, Gen. Thorac. Cardiovasc. Surg., 58:82-86, 2010.

0620D002(J.Shimizu), C.Ikeda, Y.Arano, I.Adachi, M.Morishita, S.Yamaguchi, N.Ishikawa, G.Watanabe, H.Minato: Advanced
lung cancer invading the left atrium, treated with pneumonectomy combined with left atrium resection undercardiopulmonary bypass, Ann. Thorac. Cardiovasc. Surg., 16:286-290, 2010.

0620D003(J.Shimizu), Y.Arano, I.Adachi, M.Morishita, B.Fuwa, S.Yokokawa, S.Minami, M.Hiroshi: Adenosquamous
carcinoma of the lung in a patient with complete situs inversus, Medical journal of Mutual Aid Association, 59:1822, 2010 (in Japanese) .

0620D004

M.miki, Y.Masaki, T.Nakamura, H.Iwao, A.Nakajima, T.Sakai, T.Sawaki, T.Kawanami, M.Kaito, N.Kurose,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Hirose, H.Umehara: Primary neurolymphomatosis of the cervical nerve root,
The Japanese Journal of Clinical Hematology, 51:564-567, 2010 (in Japanese) .

0620D005

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy, 37:1341-1344, 2010 (in Japanese) .

－ 116 －

Others
0620F001(J.Shimizu), Y.Arano, C.Ikeda, I.Adachi, N.Ishikawa, Y.Hirano, H.Minato: Modification of the surgical procedure toenable the complete resection of lung cancer with carcinomatous pleuritis, Surg Today, 40:890-893, 2010.

－ 117 －

0640

Endoscopy Center

Faculty
Title

Name

Field of Specialization

Assistant Professor

SAITO Takashi

Treatment for metabolic syndrome.

Keywords of Research
early esophageal cancer, gastric esophageal reflux disorder, esophageal ulcer, esophageal varix, thrombosis of esophageal
varix, peptic ulcer, acute gastric mucosal lesion, proton pump inhibitor, lansoplazole metabolism, helicobacter pylori,
eradication therapy of helicobacter pylori, early gastric cancer, endoscopic mucosal resection, endoscopic submucosal
dissection, endoscopic ultrasound, marking rivet, early colon cancer, apoptosis, vascular endothelial growth factor,
ulcerative colitis, Crohn disease

Outline of Research
1.Endoscopic treatment for early cancer of digestive organ
2.Endoscopic treatment for esophageal and gastric varices associated with portal hypertension
3.Endoscopic treatment for choledochal stone
4.Endoscopic diagnosis for pulmonary cancer

Publications
Originals
0640B001

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada,
T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Association between functional
promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan,
Cytokine., 51:173-177, 2010.

0640B002

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka,
H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Functional promoter polymorphisms of macrophagemigration inhibitory factor in peptic ulcer diseases, Int. J. Mol. Med., 26:707-711, 2010.

Case Reports
0640D001

S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki,
T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi: A case ob jejunal GIST diagnosed by double-baloon endoscopy,
Endosc. Forum digest. dis., 26:44-49, 2010 (in Japanese) .

－ 118 －

0700

Multidisciplinary Cancer Center

Title

Name

Field of Specialization

Professor(Additional Post)

TANAKA Tatsuro

Urology.

Professor(Additional Post)

TSUJI Hiroyuki

Head & Neck Surgery.

MATOBA Munetaka

Radiation Oncology.

MASAKI Yasufumi

Hematology/Oncology.

OMOTE Kazuhiko

Surgical treatment of gastric cancer.

WASADA Tomoo

reproductive medicine, perinatal medicine, gynecologic oncology.

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery.

TSUCHIHARA
Katsumaclinical respiratory medicine, lung cancer.

FUKUYAMA Tomoki

Chemotherapy for gastrointestinal malignant disease.

Faculty

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)
Senior AssistantProfessor(Additional Post)
Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)
Assistant
Professor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Researchout patient chmotherapy, clinical investigation, biomarker, multidisciplinary cancer

Outline of Research
Our main task is outpatient chemotherapy, which is requested by other Departments of the hospital. We are also involvedin clinical trials on chemotherapy, and in translational research using clinical samples such as blood and urine of patients.

Publications
Originals
0700B001

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, T.Nomura, H.Yamada, R.Hayashi, T.Saito, M.Yamada,
T.Fukuyama, T.Otsuka, H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Association between functional
promoter polymorphisms of macrophage migration inhibitory factor(MIF)gene and ulcerative colitis in Japan,
Cytokine., 51:173-177, 2010.

0700B002(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of KRAS testing and cetuximab as last-line therapy
for colorectal cancer, Mol Diagn Ther., 14:375-384, 2010.

0700B003

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

0700B004

H.Shiroeda, T.Tahara, M.Nakamura, T.Shibata, H.Yamada, T.Nomura, R.Hayashi, T.saito, T.Fukuyama, T.Otsuka,
H.Yano, K.Ozaki, M.Tsuchishima, M.Tsutsumi, T.Arisawa: Functional promoter polymorphisms of macrophagemigration inhibitory factor in peptic ulcer diseases, Int. J. Mol. Med., 26:707-711, 2010.

－ 119 －

Reviews
0700C001(C.Cano), Y.Motoo, JL.Lovanna: Epithelial- to- mesenchymal transition in pancreatic adenocarcinoma, ScientificWorld Journal., 10:1947-1957, 2010.

0700C002

T.Shimasaki, Y.Ishigaki, T.Minamoto, Y.Motoo: Application of molecular medicine to pancreatic cancer, The
Journal of Japan Pancreas Society, 25:35-45, 2010 (in Japanese) .

Case Reports
0700D001(M.Tachibana), Y.Hashimoto, T.Sone, N.Ooishi, T.Ueno, Y.Motoo: Two cases of atypical adenoma of the
thyroid―is atypical adenoma of the thyroid a true benign lesion?―, J. Jpn. Soc. Clin. Cytol., 49:190-195, 2010
(in Japanese) .

0700D002

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy., 37:1341-1344, 2010 (in Japanese) .

0700D003

S.Siroeda, H.Siroeda, T.Ootsuka, M.Yamada, T.Fukuyama, T.Saito, R.Hayashi, T.Nomura, H.Yano, K.Ozaki,
T.Arisawa, M.Yokoi, T.Kosaka, M.Tsutsumi: A case ob jejunal GIST diagnosed by double-baloon endoscopy,
Endosc. Forum digest. dis., 26:44-49, 2010 (in Japanese) .

Others
0700F001(Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki: Molecular analysis on responses of TP53INP1-knockout
mouse embryonic fibroblasts to anti-cancer agents, Study report 2009 Japan China Sasakawa Medical Fellowship,
125-128, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0700G001

Y.Motoo, K.Tsutani: “Tsutaeru ” Project on evidence of Kampo medicine: activities of the special committee for
EBM, Japan Society for Oriental Medicine, The 15th International Congress of Oriental Medicine, (Makuhari,'10.02).

0700G002

Y.Motoo: Traditional Japanese medicine in clinical practice guidelines and in multidisciplinary cancer treatment,
The 14th International Conference on Oriental Medicine of Daegu Haany & Dong-Eui University 2010, (Daegu,'10.11).

International Conference (Synposium)
0700H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

0700H002

Y.Motoo: Stress responses of pancreatic cancer cells and their significance in invasion and metastasis,
International Symposium on Primo-Vascular System 2010, (Jecheon, '10.09).

0700H003

Y.Motoo: Current status of cancer treatment in Japan, Academic lecture series on cancer: basic and clinicalaspects, (Shanghai, '10.09).

0700H004

Y.Motoo: East Meets West: Japanese experience with special reference to cancer treatment, The First BeijingInternational Symposium on Integrative Medicine, (Beijing, '10.10).

0700H005

Y.Motoo: Clinical practice guidelines containing Kampo products in Japan, First Korea-Japan Workshop on EBM
in Traditional East Asian Medicine, (Seoul, '10.10).

－ 120 －

0700H006

Y.Motoo: New Work Item Proposal (NWIP) No.2 from Japan, Joint ISO/TC215 and CEN/TC251 Working Groups
meeting, (Rotterdam, '10.10).

International Conference (Presentations)
0700I001

J.Yamakawa, J.Moriya, Y.Motoo: Three kampo medicines have different activities to regulate gene expressions indifferentiated rat white adipocytes, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0700I002

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0700I003

Y.Motoo, T.Togo, H.Toyotama, T.Seki: New work item proposal of traditional medicine, ISO/TC215 WG3 TMTF, (Rio de Janeiro, '10.05).

0700I004

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis and inhibiting apoptosis of granular cells, The 9th Meeting of the Consortium for
Globalization of Chinese Medicine 2010, (Hong Kong, '10.08).

0700I005(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of K-ras testing and cetuximab for metastatic
colorectal cancer in Japan, ISPOR 4th Asia-Pacific Conference, (Phuket, '10.09).

－ 121 －

0670

Lifestyle-related Diseases Center

Title

Name

Field of Specialization

Professor(Additional Post)

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterosecretiol.

Professor(Additional Post)

TAMURA Nobuki

Physical physiology(The exercise testing and prescription from thephysiological and biochemical research), Effects of the anemia on thephysical activitiy, Exercise therapy for the lifestyle-related disease,
Training for health Medical Education.

Associate Professor

ASAJI Takayoshi

Heart failure.

HORI Ariyuki

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning.

ITO Tomohiko

Endocrinology.

Senior Assistant Professor

UENISHI Hiroaki

Cardiovascular Medicine.

Senior Assistant Professor

KUDOH AKAZAWA
Sumiyogender specific medicine, hypertension, molecular biology.

Senior AssistantProfessor(Additional Post)

NAKANISHI Yumiko

Preventive medicine.

Assistant Professor

KAMODA Sachikolifestyle-related disease, Preventive medicine.

Assistant Professor

TERADA Maiko

lifestyle-related disease.

Assistant Professor

HAYASAKI Hisae

lifestyle-related disease.

Assistant
Professor(Additional Post)

KITADA Munehiro

diabetes, hypertension.

Faculty

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Keywords of Research
life-style related disease, metabolic syndorome, impaired glucose tolerance, hypertension, hyperlipidemia, smoking, stroke,
myocardial infarction, diet, exercise, smoking

Outline of Research
Prevention of life-style-related diseases by exercise, diet and stop-smoking.

Presentations at Conference
International Conference (Presentations)
0670I001(Hi.Akazawa), N.Yasuda, S.Kudoh akazawa, I.Komuro: Cardiac overexpression of angiotensin Ⅱtype1 receptor
induces ventricular remodeling independently of angiotensin Ⅱ, Gordon Research Conferences, (Los Angeles,'10.02).

－ 122 －

0610

Health Management Center

Faculty
Title

Name

Field of Specialization

Director

TAKASE Shujiro

Gastroenterology.

Professor

KAWAHARA Hiromu Liver injury and oxidative stress.

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine.

Professor(Additional Post)

YASUDA Yukio

evidence-based health care.

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine.

Associate Professor

NAKAMURA Koshi

Epidemiology of Cardiovascular disease and Lifestyle-related disease
Lifestyle/Disease and Medical expenditure.

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease.

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution.

Senior Assistant Professor

NAKANISHI Yumiko

Preventive medicine.

Senior Assistant Professor

KUGINUKI Yasuaki

hemodynamics.

Assistant Professor

OTA Kiyotaka

Radiology.

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, "stress, dietary habits", "nutrient intake, exercise"

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0610B001(The Emerging Risk Factors Collaboration), H.Nakagawa, Collabrators(273): C-reactive protein concentration andrisk of coronary heart disease,stroke, and mortality:an individual participant meta-analysis, Lancet, 375:132-140,
2010.

0610B002(K.Miura), N.Okuda, T.C.Turin, N.Takashima, H.Nakagawa, K.Nakamura, K.Yoshita, A.Okayama, H.Ueshima,
NIPPON DATA80/90 Research Group: Dietary salt intake and blood pressure in a representative Japanese
population: baseline analyses of NIPPON DATA80, J Epidemiol, 20(Suppl):S524-S530, 2010.

0610B003(N.Okuda), K.Miura, K.Yoshita, Y.Matsumura, A.Okayama, Y.Nakamura, T.Okamura, S.Saitoh, K.Sakata,
T.Ojima, TC.Turin, H.Ueshima, H.Nakagawa, NIPPON DATA80/90 Research Group: Integration of data fromNIPPON DATA80/90 and National Nutrition Survey in Japan: for cohort studies of representative Japanese on
nutrition, J Epidemiol, 20(Suppl):S506-S514, 2010.

0610B004

Q.LI, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa:Occupational class and incidence rates of cardiovascular events in middle aged men in Japan, Ind. Health, 48:324330, 2010.

－ 123 －

0610B005

M.Nakashima, M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, J. Atheroscler. Thromb., 17:1082-1095, 2010.

0610B006(N.Takashima), K.Miura, A.Hozawa, A.Kadota, T.Okamura, Y.Nakamura, T.Hayakawa, N.Okuda, A.Fujiyoshi,
SY.Nagasawa, T.Kadowaki, Y.Murakami, Y.Kita, A.Okayama, H.Ueshima, H.Nakagawa, NIPPON DATA 90
Research Group, Collaborator(19): Population attributable fraction of smoking and metabolic syndrome on
cardiovascular disease mortality in Japan: a 15-year follow up of NIPPON DATA90, BMC Public Health, 10:306,
2010.

0610B007(U.Tamura), T.Tanaka, T.Okamura, T.Kadowaki, H.Yamato, H.Tanaka, M.Nakamura, A.Okayama, H.Ueshima,
Z.Yamagata, HIPOP-OHP research group, H.Nakagawa: Changes in weight, cardiovascular risk factors andestimated risk of coronary heart disease following smoking cessation in Japanese male workers:HIPOP-OHP study,
J. Atheroscler. Thromb., 17:12-20, 2010.

0610B008

W.Hirokawa, K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middleaged Japanese men, J. Atheroscler. Thromb., 17:934-943, 2010.

0610B009(Z.Guo), K.Miura, TC.Turin, A.Hozawa, N.Okuda, T.Okamura, S.Saitoh, K.Sakata, H.Nakagawa, A.Okayama,
K.Yoshita, T.Kadowaki, S.R Choudhury, Y.Nakamura, B.L Rodriguez, JD.Curb, P.Elliott, J.Stamlar, H.Ueshima:
Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic
syndrome in Japanese:the INTERLIPID study, J. Atheroscler. Thromb., 17：777-784, 2010.

0610B010(S.Katano), Y.Nakamura, A.Nakamura, Y.Murakami, T.Tanaka, H.Nakagawa, T.Takebayashi, H.Yamato,
A.Okayama, K.Miura, T.Okamura, H.Ueshima, HIPOP-OHP Research Group: Relationship among physicalactivity,smoking,drinking and clustering of the metabolic syndrome diagnostic components, J. Atheroscler.
Thromb., 30:644-50, 2010.

0610B011

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse, H.Nakagawa:Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged nondiabetic Japanese men, Diabetologia, 53:1894-1902, 2010.

0610B012

R.Honda, W.Swaddiwudhipong, M.Nishijo, P.Mahasakpan, W.Teeyakasem, W.Ruangyuttikarn, S.Satarug,
C.Padungtod, H.Nakagawa: Cadmium induced renal dysfunction among residents of rice farming area downstream
from a zinc-mineralized belt in Thailand, Toxicol. Lett., 198:26-32, 2010.

0610B013(R.Oka), J.Kobayashi, A.Inazu, K.Yagi, S.Miyamoto, M.Sakurai, K.Nakamura, K.Miura, H.Nakagawa, M.Yamagishi:
Contribution of visceral adiposity and insulin resistance to metabolic risk factors in Japanese men, Metabolism,
59:748-754, 2010.

0610B014(H.Yatuya), H.Toyoshima, K.Yamagishi, K.Tamakoshi, M.Taguri, A.Harada, Y.Ohashi, Y.Kita, Y.Naito, M.Yamada,
N.Tanabe, H.Iso, H.Ueshima, H.Nakagawa, Japan Arteriosclerosis Longitudinal Study (JALS) group: Body massindex and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanesecohorts using individual data, Circ. Cardiovasc. Qual. Outcomes., 3:498-505, 2010.

0610B015(D.D.Nhu), T.Kido, R.Naganuma, H.Suzuki, N.Kuroda, S.Honma, P.T.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
N.N.Hung, L.T.H.Thom, L.K.Son: Salivary cortisol and cortisone levels,and breast milk dioxin concentrations in
Vietnamese primiparas, Toxicol. Environ. Chem., 92:1939-1952, 2010.

0610B016(R.Sato), T.Kido, R.Honda, M.Nishijo, H.Nakagawa, E.Kobayashi, Y.Suwazono: Seventeen-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan, Bull. Environ.
Contam. Toxicol., 84:363-367, 2010.

0610B017(W.Swaddiwudhipong), P.Limpatanachote, M.Nishijo, R.Honda, P.Mahasakpan, S.Krintratun: Cadmium-exposed
population in Mae Sot district, Tak province:3. associations between urinary cadmium and renal
dysfunction,hypertension,diabetes, and urinary stones, J. Med. Assoc. Thai., 93:231-238, 2010.

0610B018(P.Limpatanachote), W.Swaddiwudhipong, M.Nishijo, R.Honda, P.Mahasakpan, K.Nambunmee, W.Ruangyuttikarn:
Cadmium-exposed population in Mae Sot district, Tak province: 4 bone mineral density in persons with highcadmium exposure, J. Med. Assoc. Thai., 93:1451-1457, 2010.

－ 124 －

0610B019(R.Oka), K.Miura, M.Sakurai, K.Nakamura, K.Yagi, S.Miyamoto, T.Moriuchi, H.Mabuchi, J.Koizumi, H.Nomura,
Y.Takeda, A.Inazu, A.Nohara, MA.Kawashiri, S.Nagasawa, J.Kobayashi, M.Yamagishi: Impacts of visceral adipose
tissue and subcutaneous adipose tissue on metabolic risk factors in middle-aged Japanese, , 18:153-60, 2010.

0610B020

K.Nakamura, T.Okamura, T.Hayakawa, H.Kanda, A.Okayama, H.Ueshima, Health Promotion Research Committeeof the Shiga National Health Insurance Organizations: Medical expenditures of men with hypertension and/or asmoking habit: a 10-year follow-up study of national health insurance in Shiga, Japan, Hypertens. Res., 33:802807, 2010.

0610B021

Y.Kuginuki: Usefulness of hepatic ADC measured using 3T-MRI in evaluation of liver fibrosis, J. Kanazawa. Med.
Univ., 35:178-186, 2010 (in Japanese) .

Reviews
0610C001(R.Huxley), K.Nakamura, M.Woodward: Modification of the effect of lipids on the risk of cardiovascular diseases bycigarette smoking, Clin. Lipidol., 5:413-420, 2010.

0610C003

K.Nakamura, H.Nakagawa: Prevention of stroke, Journal of Medical Technology, 54:1487-1493, 2010 (inJapanese) .

0610C004

K.Nakamura: Impacts of cardiovascular risk factors on medical expenditures, Hokuriku Japanese Journal of Public
Health., 37:1-6, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0610I001

K.Nakamura, W.Hirokawa, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormality and risk of cardiovascular diseases among middle-aged Japanese men,
The Joint Scientific Meeting of International Epidemiological Association Western Pacific Region and 20th Japan
Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology, 20(Suppl 1):191, 2010.

0610I002

M.Sakurai, M.Nakashima, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, The Joint Scientific Meeting of International Epidemiological Association Western PacificRegion and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology,20(Suppl 1):216, 2010.

0610I003

M.Nakashima, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse: Association between
long working hours and sleep problems in white-collar workers, The Joint Scientific Meeting of International
Epidemiological Association Western Pacific Region and 20th Japan Epidemiological Association, (Koshigaya,'10.01).

－ 125 －

0680

Medical Genetic Center

Faculty
Title

Name

Field of Specialization

Director

NIIDA You

genetic diagnosis, genetic counseling.

ITO Masatsune

child endocrinology.

SATO Hitoshi

clinical virology, child infectious disease.

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

Keywords of Research
Medical genetics, Genetic services, Genetic counseling, Genetic testing, DNA diagnosis, Molecular diagnosis, Chromosomal
study

Outline of ResearchStudies and practices of useful methods of genetic concerning
Development of exhaustive and comprehensive genetic testing
Total health care of patients with genetic diseases－ 126 －

Medical Research Institute

0740

Division of Human Genetics (Biochemistry)

Faculty
Title

Name

Professor

KUHARA Tomiko

Senior Assistant Professor

INOUE Yoshito

Field of Specialization
Human metabolome analysis for diagnosis of metabolic disorders andpersonalized medicine.
Chemical diagnosis and follow up study for metabolic disorders (ureacycle disorders, prenatal diagnosis of organic acidemias, Canavan
disease, optical isomer analysis)

Keywords of Researchhuman genetics, metabolome, pharmacogenomics, nutrinogenomics, metabolomics, mass spectrometry, inborn errors of
metabolism, molecular diagnosis, organic acidemia, gas chromatography-mass spectrometry, chemical diagnosis, pilot studyof neonatal screening, prenatal diagnosis, personalized medicine, stable isotope dilution, tandem mass spectrometry,electrosplay ionization mass spectrometry, 5-fluorouracil toxicity, metabolic profiling, aminoacidemia/aminoaciduria, fatty
acid β-oxidation, carnitine, acylcarnitine

Presentations at Conference
International Conference (Presentations)
0740I001

T.Kuhara: GC/MS-based metabolomics for chemical diagnosis of IEM, The 1st Asian Congress for Inherited
Metabolic Diseases, (Fukuoka, '10.03)，Japanese Journal for Inherited Metabolic Diseases, 26(Suppl):86.

－ 127 －

0750

Division of Human Genetics (Clinical Medicine)

Faculty
Title

Name

Field of Specialization

Associate Professor

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics.

Keywords of Research
genetic counseling, genetic service, prenatal diagnosis, congenital abnormality

Publications
Originals
0750B001(N.Ba Trung), M.Saito, H.Takabayashi, P.Hung Viet, E.Tamiya, Y.Takamura: Multi-chamber PCR chip with simple
liquid introduction utilizing the gas permeability of polydimethylsiloxane, Sens Actuators B Chem., 149:284-290,
2010.

Case Reports
0750D001

K.Sato, K.Terai, M.Ozaki, Y.Ueda, S.Katsuda: Odontogenic myxofibroma with HMGA2 overexpression and

HMGA2 rearrangement, Pathol. Int., 60:760-764, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0750G001

H.Takabayashi: FDD-MB 3.0 System, 6th World Congress of Perinatal Medicine, (Indonesia, '10.03).

－ 128 －

0770

Division of Core Facility (Radioisotope Center)

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology.

Research Associate

YAMASHITA
Masatoshi

Radiation Safety Management.

Keywords of Research
RNA surveillance, nonsense mediated mRNA decay, mutation, DNA microarray, transcriptome, proteome, apoptosis,
Energy-filtering electron microscopy, Element mapping, Ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, centrosome, tumor growth angiogenesis, micro RNA

Outline of Research
Quality control of genetic information

Books
0770A001

Y.Ishigaki, A.Nagao, T.Matsunaga: Optimized gene silencing by co-expression of multiple shRNAs in a single
vector., Methods in Molecurar Biology, 109-121, Humana Press, Milton Keynes UK, 2010.

Publications
Originals
0770B001

L.Zhang, K.Higashi, Y.Ishigaki, Y.Ueda, T.Sakuma, T.Takegami, M.Oguchi, K.Xu, Y.Ohta, H.Nishida, H.Tonami:
Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as
biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma, Ann. Nucl.
Med., 24:533-540, 2010.

0770B002(T.Kiba), Y.Kintaka, Y.Suzuki, N.Ishizuka, Y.Ishigaki, S.Inoue: VMH lesions downregulate the expression of Per2
gene in the pancreas in the rat, Neurosci. Lett., 471:148-151, 2010.

0770B003(T.Kiba), Y.Kintaka, Y.Suzuki, N.Ishizuka, Y.Ishigaki, S.Inoue: Gene expression profiling in rat pancreas after
ventromedial hypothalamic lesioning, Pancreas, 39:627-632, 2010.

0770B004(M.Yamaguchi), I.Hasegawa, N.Yahagi, Y.Ishigaki, F.Takano, T.Ohta: Carotenoids modulate cytokine production in
Peyer's patch cells ex vivo, J. Agric. Food Chem., 58:8566-8572, 2010.

0770B005

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology, 24:8-13, 2010.

0770B006

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

－ 129 －

Reviews
0770C001

T.Shimasaki, Y.Ishigaki, T.Minamoto, Y.Motoo: Application of molecular medicine to pancreatic cancer, The
Journal of Japan Pancreas Society, 25:35-45, 2010 (in Japanese) .

0770C002

Y.Ueda, M.Shimasaki, Y.Machida, Y.Takahara, Y.Himi, Y.Ishigaki, K.Sato, T.Sakuma, H.Toga, S.Kawakami,
S.Katsuda: Aquaporin as a novel player in cancer cell the invasion of cancer cells, J. Kanazawa. Med. Univ.,
35:55-60, 2010 (in Japanese) .

Others
0770F001(Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki: Molecular analysis on responses of TP53INP1-knockout
mouse embryonic fibroblasts to anti-cancer agents, Study report 2009 Japan China Sasakawa Medical Fellowship,
125-128, 2010.

Presentations at Conference
International Conference (Synposium)
0770H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

International Conference (Presentations)
0770I001

T.Takegami, M.Murakami, Y.Ishigaki: Pathogenicity of Japanese encephalitis virus (JEV) and biological activity of
JEV protein NS4a, 44th US-Japan Cooperative Medical Science Program, (Sapporo, '10.07).

0770I002

T.Takegami, M.Murakami, Y.Ishigaki: Pathogenicity of Japanese encephalitis virus (JEV) and physiological role of
JEV protein NS4a, 1st Asia Pacific Workshop on Neurovirology, (Seoul, '10.07).

0770I003(T.Takahashi), T.Murayama, Y.Ishigaki, K.Ubutaka: Inhibitory Effects of Various Statins on Cytomegalovirus
Replication in Human Cells, 50th Interscience Conference on Antimicrobial Agents and Chemotherapy, (Boston,'10.09).

0770I004

T.Hatta, H.Shimada, E.Simamura, Y.Ishigaki, N.Higashi, T.Tatsuno, F.Takano: Alteratio of gene expression
profiles in the fetal cerebrum after injection of leukemia inhibitory factor into dams, Society for NEUROSCIENCE
2010, (San Diego, '10.11).

－ 130 －

0780

Division of Core Facility (Experimental Animal Center)

Faculty
Title

Name

Professor(Additional Post)

MATSUI Shinobu

Field of Specialization

Keywords of Researchcardiac function, echocardiography, myocarial metabolism, cell cycle control and immunopathology

Outline of Research
1. cardiac function, echocardiography, myocarial metabolism.
2. cell cycle control and immunopathology.

－ 131 －

0800

Division of Core Facility (High-Tech Research Center)

Faculty
Title

Name

Field of Specialization

Associate
Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution.

Researcher

SUN Peng

Researcher

TAKATA Takanobu

Researcher

WANG Furong

Researcher

ZHANG Qing

Analysis of mood disorder model mice in search for new therapeutic
approaches
Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'.
Analysis of Alzheimer disease model mice in search for new
therapeutic approaches
Physiological analysis of anti-NMDA receptor antibody accompanying
autoimmune encephalitis

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. neurovirology.
3. Cancer chemoprevention by natural products.

Publications
Originals
0800B001(K.Nambunmee), R.Honda, M.Nishijo, W.Swaddiwudhipong, H.Nakagawa, W.Ruangyuttikarn: Bone resorption
acceleration and calcium reabsorption impairment in a Thai population with high cadmium exposure, Toxicol. Mech.
Methods., 20:7-13, 2010.

0800B002(The Emerging Risk Factors Collaboration), H.Nakagawa, Collabrators(273): C-reactive protein concentration andrisk of coronary heart disease,stroke, and mortality:an individual participant meta-analysis, Lancet, 375:132-140,
2010.

0800B003(K.Miura), N.Okuda, T.C.Turin, N.Takashima, H.Nakagawa, K.Nakamura, K.Yoshita, A.Okayama, H.Ueshima,
NIPPON DATA80/90 Research Group: Dietary salt intake and blood pressure in a representative Japanese
population: baseline analyses of NIPPON DATA80, J Epidemiol, 20(Suppl):S524-S530, 2010.

0800B004(N.Okuda), K.Miura, K.Yoshita, Y.Matsumura, A.Okayama, Y.Nakamura, T.Okamura, S.Saitoh, K.Sakata,
T.Ojima, TC.Turin, H.Ueshima, H.Nakagawa, NIPPON DATA80/90 Research Group: Integration of data fromNIPPON DATA80/90 and National Nutrition Survey in Japan: for cohort studies of representative Japanese on
nutrition, J Epidemiol, 20(Suppl):S506-S514, 2010.

0800B005

Q.LI, Y.Morikawa, M.Sakurai, K.Nakamura, K.Miura, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono, H.Nakagawa:Occupational class and incidence rates of cardiovascular events in middle aged men in Japan, Ind. Health, 48:324330, 2010.

0800B006

M.Nakashima, M.Sakurai, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, J. Atheroscler. Thromb., 17:1082-1095, 2010.

－ 132 －

0800B007(N.Takashima), K.Miura, A.Hozawa, A.Kadota, T.Okamura, Y.Nakamura, T.Hayakawa, N.Okuda, A.Fujiyoshi,
SY.Nagasawa, T.Kadowaki, Y.Murakami, Y.Kita, A.Okayama, H.Ueshima, H.Nakagawa, NIPPON DATA 90
Research Group, Collaborator(19): Population attributable fraction of smoking and metabolic syndrome on
cardiovascular disease mortality in Japan: a 15-year follow up of NIPPON DATA90, BMC Public Health, 10:306,
2010.

0800B008(U.Tamura), T.Tanaka, T.Okamura, T.Kadowaki, H.Yamato, H.Tanaka, M.Nakamura, A.Okayama, H.Ueshima,
Z.Yamagata, HIPOP-OHP research group, H.Nakagawa: Changes in weight, cardiovascular risk factors andestimated risk of coronary heart disease following smoking cessation in Japanese male workers:HIPOP-OHP study,
J. Atheroscler. Thromb., 17:12-20, 2010.

0800B009

W.Hirokawa, K.Nakamura, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormalities, abdominal obesity and the risk of cardiovascular diseases in middleaged Japanese men, J. Atheroscler. Thromb., 17:934-943, 2010.

0800B010(Z.Guo), K.Miura, TC.Turin, A.Hozawa, N.Okuda, T.Okamura, S.Saitoh, K.Sakata, H.Nakagawa, A.Okayama,
K.Yoshita, T.Kadowaki, S.R Choudhury, Y.Nakamura, B.L Rodriguez, JD.Curb, P.Elliott, J.Stamlar, H.Ueshima:
Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic
syndrome in Japanese:the INTERLIPID study, J. Atheroscler. Thromb., 17：777-784, 2010.

0800B011(S.Katano), Y.Nakamura, A.Nakamura, Y.Murakami, T.Tanaka, H.Nakagawa, T.Takebayashi, H.Yamato,
A.Okayama, K.Miura, T.Okamura, H.Ueshima, HIPOP-OHP Research Group: Relationship among physicalactivity,smoking,drinking and clustering of the metabolic syndrome diagnostic components, J. Atheroscler.
Thromb., 30:644-50, 2010.

0800B012

K.Nakamura, M.Sakurai, K.Miura, Y.Morikawa, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse, H.Nakagawa:Homeostasis model assessment of insulin resistance and the risk of cardiovascular events in middle-aged nondiabetic Japanese men, Diabetologia, 53:1894-1902, 2010.

0800B013

R.Honda, W.Swaddiwudhipong, M.Nishijo, P.Mahasakpan, W.Teeyakasem, W.Ruangyuttikarn, S.Satarug,
C.Padungtod, H.Nakagawa: Cadmium induced renal dysfunction among residents of rice farming area downstream
from a zinc-mineralized belt in Thailand, Toxicol. Lett., 198:26-32, 2010.

0800B014(R.Oka), J.Kobayashi, A.Inazu, K.Yagi, S.Miyamoto, M.Sakurai, K.Nakamura, K.Miura, H.Nakagawa, M.Yamagishi:
Contribution of visceral adiposity and insulin resistance to metabolic risk factors in Japanese men, Metabolism,
59:748-754, 2010.

0800B015(H.Yatuya), H.Toyoshima, K.Yamagishi, K.Tamakoshi, M.Taguri, A.Harada, Y.Ohashi, Y.Kita, Y.Naito, M.Yamada,
N.Tanabe, H.Iso, H.Ueshima, H.Nakagawa, Japan Arteriosclerosis Longitudinal Study (JALS) group: Body massindex and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanesecohorts using individual data, Circ. Cardiovasc. Qual. Outcomes., 3:498-505, 2010.

0800B016(D.D.Nhu), T.Kido, R.Naganuma, H.Suzuki, N.Kuroda, S.Honma, P.T.Tai, S.Maruzeni, M.Nishijo, H.Nakagawa,
N.N.Hung, L.T.H.Thom, L.K.Son: Salivary cortisol and cortisone levels,and breast milk dioxin concentrations in
Vietnamese primiparas, Toxicol. Environ. Chem., 92:1939-1952, 2010.

0800B017

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology., 24:8-13, 2010.

0800B018

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

0800B019(R.Sato), T.Kido, R.Honda, M.Nishijo, H.Nakagawa, E.Kobayashi, Y.Suwazono: Seventeen-year observation on
urinary cadmium and β2-microglobulin in inhabitants after cessation of cadmium-exposure in Japan, Bull. Environ.
Contam. Toxicol., 84:363-367, 2010.

0800B020(W.Swaddiwudhipong), P.Limpatanachote, M.Nishijo, R.Honda, P.Mahasakpan, S.Krintratun: Cadmium-exposed
population in Mae Sot district, Tak province:3. associations between urinary cadmium and renal
dysfunction,hypertension,diabetes, and urinary stones, J. Med. Assoc. Thai., 93:231-238, 2010.

－ 133 －

0800B021(P.Limpatanachote), W.Swaddiwudhipong, M.Nishijo, R.Honda, P.Mahasakpan, K.Nambunmee, W.Ruangyuttikarn:
Cadmium-exposed population in Mae Sot district, Tak province: 4 bone mineral density in persons with highcadmium exposure, J. Med. Assoc. Thai., 93:1451-1457, 2010.

Presentations at Conference
International Conference (Synposium)
0800H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

International Conference (Presentations)
0800I001

M.Ishizaki, H.Nakagawa, N.Kawakami, A.Inoue, Y.Morikawa, T.Kido, Y.Yamada: Relationship between job stressand job performance in a factory, The Joint Scientific Meeting of International Epidemiological Association Western
Pacific Region and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of
Epidemiology, 20(Suppl 1):295, 2010.

0800I002

K.Nakamura, W.Hirokawa, M.Sakurai, Y.Morikawa, K.Miura, M.Ishizaki, K.Yoshita, T.Kido, Y.Naruse,
H.Nakagawa: Mild metabolic abnormality and risk of cardiovascular diseases among middle-aged Japanese men,
The Joint Scientific Meeting of International Epidemiological Association Western Pacific Region and 20th Japan
Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology, 20(Suppl 1):191, 2010.

0800I003

M.Sakurai, M.Nakashima, K.Nakamura, K.Miura, K.Yoshita, Y.Morikawa, M.Ishizaki, K.Murakami, T.Kido,
Y.Naruse, S.Sasaki, H.Nakagawa: Dietary glycemic index, glycemic load and blood lipid levels in middle-aged
Japanese men and women, The Joint Scientific Meeting of International Epidemiological Association Western PacificRegion and 20th Japan Epidemiological Association, (Koshigaya, '10.01)，Supplement to Journal of Epidemiology,20(Suppl 1):216, 2010.

0800I004

N.Kato, P.Sun, Y.Zhang, F-R.Wang, L.Wang, R.Yamamoto, T.Sugai, Z-D.Wang, R.Chen: Increased excitability of
cingulate cortex neurons in a mouse model of depression, Cold Spring Harbor Asia Conference1st Francis Crick
Neuroscience Symposium, (Suzhou, '10.04).

0800I005

K.Kitaoka, M.Nagai, H.Nakagawa, S.Masuda, K.Ogino: Burnout levelo of the Japanese working population, ICOHN& ACOHN Joint Conference 2010, (Yokohama, '10.08).

0800I006

M.Nishijo, W.Swaddiwudhipong, K.Nambunmee, W.Ruangyuttikam, R.Honda, Y.Morikawa, H.Nakagawa: Effect of
cadmium on health risk of arterioselerosis; a study of Thai population environmentary exposed to cadmium, 6thconference on molecular mechanisums of metal toxicity and carcinogenesis, (Kentucky, '10.11).

0800I007

N.Kato, F.Wang, Y.Zhang, L.Wang, P.Sun, R.Yamamoto, T.Sugai, Z.Wang: Improved learning parallels
normalization of electrophysiological properties after transcranial magnetic stimulation in a mouse alzheimer's
disease model, Neuroscience 2010, (San Diego, '10.11).

－ 134 －

0900

Division of Cell Medicine

Faculty
Title

Name

Field of Specialization

Professor

FUJIKAWA Kohzaburo polyploid cells, cell cycle,transformation.

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology.

Keywords of Research
polyploid cells, polyploidization, Meth-A cells, V79 cells, triploid cells, tetraploid cells, octaploid cells, H-1(ES)cells

Outline of Research
Study of polyploid cells

Publications
Originals
0900B001

K.Fujikawa-Yamamoto, X.Luo, M.Miyagoshi, H.Yamagishi: DNA stable pentaploid H1(ES) cells obtained from an
octaploid cell induced from tetraploid cells polyploidized using demecolcine, J.Cell.Physiol., 223:369-375, 2010.

0900B002

X.Luo, K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi: Different responses between diploid and tetraploid H1
embryonic stem cells appeared during long-term culturing in L15F10 medium without leukemia inhibitory factor,
Hum. Cell., 23:134-140, 2010.

Reviews
0900C001

K.Fujikawa-Yamamoto: Log channel DNA histograms, Cytometry Res., 20:57-63, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0900I001

K.Fujikawa-Yamamoto, M.Miyagoshi, H.Yamagishi, L.Xianwen: DNA stability of decaploid H1(ES) cells induced
from DNA-stable pentaploid cells originated from an octaploid cell, ISAC XXV International Congress, (Seattle,'10.05).

－ 135 －

0910

Division of Advanced Medicine

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Shinobu

Clinical cardiology.

Professor

TOMOSUGI Naohisa

Clinical Proteomics.

Professor(Additional Post)

DATE Takayasu

Function of protein Kinase, PKU-β/TLK1 and PKU-α/TLK2

Associate Professor

NAGAO Yosinobu

spermatogenesis, epigenetics, endocrine disruptors.

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry.

Keywords of Researchheart failure, cardiomyopathy, nerohumoral factor, immunity, autoantibody, spermatogenesis, cell cycle, epigenetics,
endocrine disruptors, meiosis

Outline of Research
1.Myocardial injury due to autoimmunity against G-protein-coupled receptor. Growing evidence suggested that G-proteincoupled receptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated
cardiomyopathy. Our study showed that specific removal of anti-G-protein coupled receptor autoantibodies improved
cardiac structure and function in experimental autoimmune cardiomyopathy.
2.Hepcidin, a key regulator of iron metabolism, is expressed in the liver, distributed in blood, and excreted in urine.
However, to date, no reliable and practical method for measuring the bioactive form of hepcidin in serum has beendeveloped. Here, we employed surface-enhanced laser desorption ionization time of flight mass spectrometry (SELDI-TOFMS) to analyze the expression of serum hepcidin in hemodialysis patients. Hepcidin-25 was found to accumulate in theserum of hemodialysis patients; this could contribute to the pathogenesis of renal anemia by decreasing the available ironfor hematopoiesis.
3.Histone modifications in meiotic prophase of spermatogenesis.

Publications
Originals
0910B001(M.Matsumoto), T.Tsujino, Masaaki Lee-Kawabata, Y.Naito, H.Akahori, T.Sakoda, M.Ohyanagi, N.Tomosugi,
T.Masuyama: Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia, Circ. J.,
74:301-306, 2010.

0910B002(K.Kusama-Eguchi), Y.Yamazaki, T.Ueda, A.Suda, Y.Hirayama, F.Ikegami, K.Watanabe, M.May, F.Lambein,
T.Kusama: Hind-limb paraparesis in a rat model for neurolathyrism associated with apoptosis and an impaired
vascular endothelial growth factor system in the spinal cord, J. Comp. Neurol., 518:928-942, 2010.

0910B003(M.Hashizume), Y.Uchiyama, N.Horai, N.Tomosugi, M.Mihara: Tocilizumab, a humanized anti-interleukin-6
receptor antibody, improved anemia in monkey arthritis by suppressing IL-6-inducued hepcidin production,
Rheumatol. Int., 30:917-923, 2010.

0910B004(Y.Kaneko), H.Miyajima, A.Piperno, N.Tomosugi, H.Hayashi, N.Morotomi, K.Tsuchida, T.Ikeda, A.Ishikawa,
Y.Ota, S.Wakusawa, K.Yoshioka, S.Kono, S.Pelucchi, A.Hattori, Y.Tatsumi, T.Okada, M.Yamagishi: Measurementof serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders, J.
Gastroenterol., 45:1163-1171, 2010.

0910B005(S.Kono), K.Yoshida, N.Tomosugi, T.Terada, Y.Hamaya, S.Kanaoka, H.Mitajima: Biological effects of mutant
ceruloplasmin on hepcidin-mediated internalization of ferroportin, Biochim. Biophys. Acta, 1802:968-975, 2010.

－ 136 －

0910B006(S.Nakazawa J.Song), N.Tomosugi, H.Kawabata, T.Ishikawa, T.Nishikawa, K.Yoshizaki: Down-regulation of
hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia ofinflammation in multicentric Castleman disease, Blood, 116:3627-3634, 2010.

0910B007(H.Hayashi), A.Piperno, N.Tomosugi, K.Hayashi, F.Kimura, S.Wakusawa, M.Yano, Y.Tatsumi, A.Hattori,
S.Pelucchi, Y.Katano, H.Goto: Patients with chronic hepatitis C may be more sensitive to iron hepatotoxicity thanpatients with HFE-hemochromatosis, Intern. Med., 49:2371-2377, 2010.

0910B008(T.Kosuge), T.Sawada, M.Shimoda, J.Kita, N.Tomosugi, K.Kubota: Increased hepcidin production impairs ironmetabolism after pancreatoduodenectomy, World J Surg., 34:2452-2456, 2010.

0910B009

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology, 24:8-13, 2010.

0910B010

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

Presentations at Conference
International Conference (Synposium)
0910H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

－ 137 －

0920

Division of Molecular Oncology and Virology

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis.

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology.

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis.

Assistant Professor

MURAKAMI Manabu

Pathogeｎｉcity of flavivirus isolated from the field-collectedmosquitoes.

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, hepatitis C virus, flavivirus, Japanese encephalitis
virus, virus replication, RhoGDI, Rho family, Eomes, epithelial/mesenchymal, nonstructural protein NS3, RNA synthesis,
transfection, persistent infection, RNAi

Outline of Research
Molecular analyses of virus replication, carcinogenesis and metastasis

Publications
Originals
0920B001

J.Yamakawa, J.Moriya, T.Takahashi, A.Ishige, Y.Motoo, F.Yoshizaki, T.Kanda: A Kampo medicine, boiogito,
inhibits obesity in ovariectomized rats, Evid Based Complement Alternat Med, 7:87-95, 2010.

0920B002

L.Zhang, K.Higashi, Y.Ishigaki, Y.Ueda, T.Sakuma, T.Takegami, M.Oguchi, K.Xu, Y.Ohta, H.Nishida, H.Tonami:
Assessment of VEGF-D expression measured by immunohistochemical staining and F-18 FDG uptake on PET as
biological prognostic factors for recurrence in patients with surgically resected lung adenocarcinoma, Ann. Nucl.
Med., 24:533-540, 2010.

0920B003

Y.Ishigaki, T.Kurihara, Y.Nakamura, X.Zhao, T.Takata, S.Izumi, T.Takegami, N.Tomosugi, H.Nakagawa:Ultrastructural localization of Upf2 and its binding to mRNA molecules in human cells, Journal of Electron
Microscopy Technology for Medicine and Biology, 24:8-13, 2010.

0920B004

Y.Jiang, Z.Jin, H.Umehara, T.Ota: Cholesterol-dependent induction of dendrite formation by ginsenoside Rh2 incultured melanoma cells, Int. J. Mol. Med., 26: 787-793, 2010.

0920B005(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of KRAS testing and cetuximab as last-line therapy
for colorectal cancer, Mol Diagn Ther., 14:375-384, 2010.

0920B006

H.Nakajima, Y.Ishigaki, QI-S.Xia, T.Ikeda, Y.Yoshitake, H.Yonekura, T.Nojima, T.Tanaka, H.Umehara,
N.Tomosugi, T.Takata, T.Shimasaki, N.Nakaya, I.Sato, K.Kawakami, K.Koizumi, T.Minamoto, Y.Motoo: Inductionof HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock
stimulation, Int. J. Oncol., 37:583-593, 2010.

0920B007(S.Nukuzuma), K.Nakamichi, M.Kameoka, S.Sugiura, C.Nukuzuma, I.Miyoshi, T.Takegami: Efficient propagation ofprogressive multifocal leukoencephalopathy-type JC virus in COS-7-derived cell lines stably expressing Tat
protein of human immunodeficiency virus type 1, Microbiol. Immunol., 54:758-762, 2010.

－ 138 －

Reviews
0920C001(C.Cano), Y.Motoo, JL.Lovanna: Epithelial- to- mesenchymal transition in pancreatic adenocarcinoma, ScientificWorld Journal., 10:1947-1957, 2010.

0920C002

T.Shimasaki, Y.Ishigaki, T.Minamoto, Y.Motoo: Application of molecular medicine to pancreatic cancer, The
Journal of Japan Pancreas Society, 25:35-45, 2010 (in Japanese) .

Case Reports
0920D001(M.Tachibana), Y.Hashimoto, T.Sone, N.Ooishi, T.Ueno, Y.Motoo: Two cases of atypical adenoma of the
thyroid―is atypical adenoma of the thyroid a true benign lesion?―, J. Jpn. Soc. Clin. Cytol., 49:190-195, 2010
(in Japanese) .

0920D002

I.Sato, N.Ueda, E.Kinoshita, H.Mnato, K.Ohno, N.Nakata, T.Shimasaki, H.Nakajima, T.Kosaka, Y.Motoo:
Curatively resected case of non-functioning pancreatic neuroendocrine carcinoma with multiple liver metasta-ses
after dpwmstaging with S-1 monotherapy, Cancer & chemotherapy, 37:1341-1344, 2010 (in Japanese) .

Others
0920F001(Q.Bian), Y.Motoo, H.Nakajima, T.Shimasaki, Y.Ishigaki: Molecular analysis on responses of TP53INP1-knockout
mouse embryonic fibroblasts to anti-cancer agents, Study report 2009 Japan China Sasakawa Medical Fellowship,
125-128, 2010.

Presentations at Conference
International Conference (Key Note Lecture)
0920G001

Y.Motoo, K.Tsutani: “Tsutaeru ” Project on evidence of Kampo medicine: activities of the special committee for
EBM, Japan Society for Oriental Medicine, The 15th International Congress of Oriental Medicine, (Makuhari,'10.02).

0920G002

Y.Motoo: Traditional Japanese medicine in clinical practice guidelines and in multidisciplinary cancer treatment,
The 14th International Conference on Oriental Medicine of Daegu Haany & Dong-Eui University 2010, (Daegu,'10.11).

International Conference (Synposium)
0920H001

T.Shimasaki, Y.Ishigaki, T.Takata, Y.Nakamura, A.Kitano, K.Kawakami, N.Tomosugi, T.Minamoto, Y.Motoo:
Effect of GSK3β inhibition against Gemcitabine-induced epithelial-mesenchymal transition and invasive ability ofpancreatic cancer cells: its therapeutic implication, Joint Meeting of the International Association of Pancreatology
and the Japan Pancreas Society 2010, (Fukuoka, '10.07)，Pancreas, 25：291, 2010.

0920H002

Y.Motoo: Stress responses of pancreatic cancer cells and their significance in invasion and metastasis,
International Symposium on Primo-Vascular System 2010, (Jecheon, '10.09).

0920H003

Y.Motoo: Current status of cancer treatment in Japan, Academic lecture series on cancer: basic and clinicalaspects, (Shanghai, '10.09).

0920H004

Y.Motoo: East Meets West: Japanese experience with special reference to cancer treatment, The First BeijingInternational Symposium on Integrative Medicine, (Beijing, '10.10).

0920H005

Y.Motoo: Clinical practice guidelines containing Kampo products in Japan, First Korea-Japan Workshop on EBM
in Traditional East Asian Medicine, (Seoul, '10.10).

0920H006

Y.Motoo: New Work Item Proposal (NWIP) No.2 from Japan, Joint ISO/TC215 and CEN/TC251 Working Groups
meeting, (Rotterdam, '10.10).

－ 139 －

International Conference (Presentations)
0920I001

J.Yamakawa, J.Moriya, Y.Motoo: Three kampo medicines have different activities to regulate gene expressions indifferentiated rat white adipocytes, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0920I002

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis, The 15th International Congress of Oriental Medicine, (Makuhari, '10.02).

0920I003

Y.Motoo, T.Togo, H.Toyotama, T.Seki: New work item proposal of traditional medicine, ISO/TC215 WG3 TMTF, (Rio de Janeiro, '10.05).

0920I004

T.Takegami, M.Murakami, Y.Ishigaki: Pathogenicity of Japanese encephalitis virus (JEV) and biological activity of
JEV protein NS4a, 44th US-Japan Cooperative Medical Science Program, (Sapporo, '10.07).

0920I005

T.Takegami, M.Murakami, Y.Ishigaki: Pathogenicity of Japanese encephalitis virus (JEV) and physiological role of
JEV protein NS4a, 1st Asia Pacific Workshop on Neurovirology, (Seoul, '10.07).

0920I006

J.Moriya, J.Yamakawa, Y.Motoo: Resveratrol improves hippocampal atrophy in mice with chronic fatigue byenhancing neurogenesis and inhibiting apoptosis of granular cells, The 9th Meeting of the Consortium for
Globalization of Chinese Medicine 2010, (Hong Kong, '10.08).

0920I007(T.Shiroiwa), Y.Motoo, K.Tsutani: Cost-effectiveness analysis of K-ras testing and cetuximab for metastatic
colorectal cancer in Japan, ISPOR 4th Asia-Pacific Conference, (Phuket, '10.09).

－ 140 －

0930

Division of Dermatomycology (Novartis Pharma)

Faculty
Title

Name

Professor(Additional Post)

MOCHIZUKI Takashi Medical mycology, Dermatomycosis.

Assistant
Professor(Additional Post)
Assistant
Professor(Additional Post)

Field of Specialization

KAWASAKI Masako

Medical mycology

ANZAWA Kazushi

Medical mycology.

Keywords of Research
fungi, dermatophytes, Candida spesies, Sporothrix spesies, dematiaceous fungi, mitochondrial DNA, restriction fragment
length polymorphism, ribosomal DNA, ITS region, sequencing, phylogeny, taxonomy, molecular epidemiology, moleculartypingOutline of Research
Research activities in the Division of Dermatomycology are as follows:
1. Improvement and application of genetic typing of Candida albicans to investigate the fungal flora in oral cavities ofpatients.
2. Improvement and application of DNA extraction from nail and PCR-RFLP methods for identification of fungal elements innail for the diagnosis of onycomycosis.
3. Identification of isolates and isolation and identification of fungi from samples sent from nation-wide hospitals to support
clinics without molecular biological facilities.
4. Conservation of a fungal collection held in the Department of Dermatology.
5. An epidemiological survey of Trichophyton tonsurans

Books
0930A002

T.Mochizuki: Fungal Infections, Therapy of Skin Diseases (In Krieg T, Bickers D, Miyachi Y (Eds), 149-156,
Springer-Verlag, Berlin Heidelberg Germany, 2010.

Publications
Originals
0930B001
0930B002(S.Watanabe), T.Harada, M.Hiruma, K.Iozumi, T.Katoh, T.Mochizuki, W.Naka: Epidemiological survey of footdiseases in Japan: Results of 30 000 foot checks by dermatologists, J. Dermatol., 37:397-406, 2010.
K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Successful mating of Trichophyton rubrum with Arthroderma

simii, Med. Mycol., 48:629-634, 2010.
0930B003

A.Wakasa, K.Anzawa, M.Kawasaki, T.Mochizuki: Molecular typing of Trichophyton mentagrophytes var.
interdigitale isolated in a university hospital in Japan based on the non-transcribed spacer region of the ribosomal
RNA gene, J. Dermatol., 37:431-440, 2010.

0930B004(M.Yanagihara), M.Kawasaki, H.Ishizaki, K.Anzawa, S.Udagawa, T.Mochizuki, Y.Sato, N.Tachikawa, H.Hanakawa:Tiny keratotic brown lesions on the interdigital web between the toes of a healthy man caused by Curvularia
species infection and a review of cutaneous Curvularia infections, Mycoscience., 51:224-233, 2010.

－ 141 －

0930B005

M.Kawasaki, K.Anzawa, A.Wakasa, K.Takeda, T.Mochizuki, H.Ishizaki, B.Hemashettar: Matings among threeteleomorphs of Trichophyton mentagrophytes, Jpn. J. Med. Mycol., 51:143-152, 2010.

Case Reports
0930D001

0930D003

K.Takeda, J.Fujita, T.Fujii, H.Tanabe, T.Mochizuki, M.Yanagihara: Case of remitting seronegative symmetricalsynovitis with pitting edema (RS3PE syndrome) showing dermatomyositis-like eruption, J. Dermatol., 37:102-106,
2010.
M.Nanbu, T.Fujii, S.Abe, M.Kawasaki, T.Mochizuki: Cutaneous phaeohyphomycosis Caused by Exophiala

jeanselmei, Skin research, 9:173-179, 2010 (in Japanese) .
0930D004

T.Sakamoto, T.Ushigami, K.Anzawa, T.Fujii, S.Abe, T.Mochizuki, Y.Hayashi: A Case of Sporotrichosis Promptly
Diagnosed by Direct PCR, Skin research, 9:254-259, 2010 (in Japanese) .

Presentations at Conference
International Conference (Presentations)
0930I001

M.Kawasaki, K.Anzawa, A.Nishibu, H.Tanabe, H.Ishizaki, T.Mochizuki: Mating behavior and phylogenetic
incongruity among Trichophyton and Arthroderma species, 9th International Mycological Congress, IMC9: Thebiology of fungi, (Edinburgh, '10.08).

0930I002

K.Takeda, A.Nishibu, H.Tanabe, K.Anzawa, M.Kawasaki, T.Mochizuki, H.Ishizaki: Twenty three cases of tinea
capitis at the Kanazawa Medical University Hospital, The First Eastern Asia Dermatology Congress, (Fukuoka,'10.09).

－ 142 －

0970

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis.

Visiting Professor

SASAKI Kazuyuki

Associate
Professor(Additional Post)
Senior AssistantProfessor(Additional Post)
Researcher

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy.

KAWAKAMI Yutaka

cataract, thyroid ocular.

YAMASHIRO Yoko

ｃataract，electromagnetic wave induced ocular tissue changes，
epidemiology

Keywords of Research
electromagnetic waves, micro waves, millimeter waves, ultraviolet rays, infrared rays, non ionizing-radiation, mobile phone,environmental health, cataract epidemiology, prevention of blindness, cataract, pterygium, glaucoma, age related maculardegeneration, JICA, WHO, outdoor temperature, risk factors search, Reykjavik eye study, Monzen eye study, Liaoning eye
study, racial differences

Outline of Research
Main research themes are (1) Population based survey of ocular diseases in the farmers with low income living in the small
village of Shanxi Province.
China and (2) Radio frequency (RF) effects on health ; Acute ocular tissue damages by 60 GHz RF exposure. Study No.1 :The survey was carried as a part of JICA project on July 2006. Total number of participants was 710, response ratio was
93.9%. Cataract was a top ranked blindness cause. Although, number of patients was small, cases with diabetic retinopathy
and age related macular degeneration were noticed. No.2 : The study on acute ocular tissues injuries induced in rabbit eyesby exposure of 60 GHz millimeter RF has been carried out. No ocular injuries were noticed without high dose of the above
RF exposure. Among corneal superficial damages which were pointed our by previous investigators, no RF exposure specificdamages were seen. No one has pointed out the above up to now.

Publications
Originals
0970B001

J.Qu, H.Sasaki, Y.Sakamoto, Y.Kawakami, K.Sasaki, F.Jonasson: Higher-order ocular aberrations caused by
crystalline lens waterclefts, J. Cataract Refract. Surg., 36:799-805, 2010.

0970B002(A.Hirata), M.Kojima, H.Kawai, Y.Yamashiro, S.Watanabe, H.Sasaki, O.Fujiwara: Acute dosimetry and estimationof threshold-inducing behavioral signs of thermal stress in rabbits at 2.45-GHz microwave exposure, IEEE Trans.
Microw. Theory Tech., 57:1234-1242, 2010.

0970B003(A.Arnarsson), F.Jonasson, KF.Damji, MS.Gottfredsdottir, T.Sverrisson, H.Sasaki: Exfoliation syndrome in the
Reykjavik eye study : risk factors for baseline prevalence and 5-year incidence, Br. J. Ophthalmol., 94:831-835,
2010.

－ 143 －

Presentations at Conference
International Conference (Presentations)
0970I001

M.Kojima, Y.Yamashiro, T.Sasaki, Y.Suzuki, K.Sasaki, H.Sasaki: Analysis of heat transportation to crystalline lenssurface by aqueous aqueous humor convection, The Association for Research in Vision and Ophthalmology,(Florida, '10.05).

0970I002(T.Tarura), K.Sasaki, Y.Sakamoto, N.Hatsusaka, D.Lom, HM.Cheng, F.Jonasson, H.Sasaki: A comparison ofocular sturcture and optical systems in eyes of middle-aged Taiwanese and Icelanders, The Association for
Research in Vision and Ophthalmology, (Florida, '10.05).

0970I003

H.Sasaki, N.Mita, Y.Sakamoto, E.Shibuya, N.Hatsusaka, F.Jonasson, K.Sasaki: Verification of predictive accuracyof index of lens transparency using a Scheimpflug camera and 12-year follow-up, The Association for Research invision and Ophthalmology, (Florida, '10.05).

0970I004

N.Hatsusaka, Y.Sakamoto, N.Mita, E.Shibuya, J.Qu, H.Sasaki: Relationship of axial length to myopic influence on
nuclear cataract, The Association for Research in vision and Ophthalmology, (Florida, '10.05).

0970I005

N.Shibata, K.Kitagawa, Y.Sakamoto, Y.Yamashiro, N.Fujita, N.Hatsusaka, H.Sasaki: Changes in corneal higher
order aberration after pterygium excision, The Association for Research in Vision and Ophthalmology, (Florida,'10.05).

0970I006

Y.Yamashiro, K.Sato, A.Hirata, M.Kojima, T.Sakai, S.Watanabe, M.Taki, Y.Suzuki, K.Sasaki, H.Sasaki: Normalized
temperature elevation velocity in ocular tissues by 18-40 GHz radio-frequency exposure, The Association for
Research in Vision and Ophthalmology, (Florida, '10.05).

0970I007

Y.Sakamoto, N.Hatsusaka, E.Shibuya, N.Mita, J.Qu, H.Sasaki, H.Nakaizumi, K.Sasaki: Deterioration nquality ofvision by nono-opaque watercleft lens defects, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0970I008

H.Osada, Y.Yamashiro, R.Honda, M.Kojima, Y.Sakamoto, N.Hatsusaka, M.Tarura, Y.Kawakami, J.Qu, HM.Cheng,
K.Sasaki, H.Sasaki: Prevalence of cataract in anurban region of Taiwan comparison with three different areas in
China and an area in Japan, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0970I009

M.Kojima, Y.Yamashiro, K.Sasaki, H.Sasaki: Examination of threshold 60 Ghz Millimeter wave ocular exposure in
rabbit, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0970I010

N.Hatsusaka, Y.Sakamoto, E.Shibuya, N.Mita, Y.Kawakami, N.Fujita, H.Osada, S.Inagaki, N.Shibata, H.Sasaki:
Refractive power of nuclear cataract eyes and influence on myopia, The 8th Asian Cataract Research Conference,(Hangzhou, '10.06).

0970I011

N.Mita, N.Hatsusaka, E.Shibuya, Y.Sakamoto, F.Jonasson, K.Sasaki, H.Sasaki: Prediction of aging change in lensof normal Icelanders Reykjavik eye Study, The 8th Asian Cataract Research Conference, (Hangzhou, '10.06).

0970I012

E.Shibuya, J.Qu, Y.Sakamoto, N.Hatsusaka, N.Mita, M.Kojima, F.Jonasson, K.Sasaki, H.Sasaki: Natural course ofcortical opacity over 12 years Reykjavik Eye study, The 8th Asian Cataract Research Conference, (Hangzhou,'10.06).

0970I013(Y.Suzuki), M.Kojima, T.Sakai, Y.Yamashiro, T.Taguchi, A.Koike, M.Taki, K.Sasaki, H.Sasaki: Experimental anal
ysis on the thermal convection of aqueous humor in anterior chamber driven by the millimrter-wave exposure at
77GHZ, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

0970I014

M.Kojima, S.Taiji, Y.Yamashiro, Y.Suzuki, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki: Mechanism of ocularthmperature difference between 18 and 40 HGZ exposure, The Bioelectromagnetics Society 32nd annual Meeting,(Seoul, '10.06).

0970I015

Y.Yamashiro, A.Hirata, K.Sato, M.Kojima, T.Sakai, S.Watanabe, K.Wake, M.Taki, Y.Suzuki, Y.Kamimura,
Y.Sakamoto, Y.Kawakami, K.Sasaki, H.Sasaki: Comparison of temperature in ocular tissues by 18-40 GHZ radiofrequency exposure, The Bioelectromagnetics Society 32nd annual Meeting, (Seoul, '10.06).

0970I016(A.Koike), Y.Suzuki, T.Taguchi, M.Kojima, Y.Yamashiro, T.Sakai, S.Watanabe, M.Taki, K.Sasaki, H.Sasaki:
Velocimetry on thermal convection flow of aqueous humor in anterior chamber caused by millimeter-wave
exposure, 2010 Asis-Pacific Radio Science Congerence, (Toyama, '10.09).

－ 144 －

0970I017

M.Kojima, Y.Yamashiro, H.Sasaki, K.Sasaki, T.Sakai, K.Wake, S.Watanabe, Y.Kamimura, A.Hirata, Y.Suzuki,
M.Taki: Verification of sagety guidelines for 60 GHz millimeter wave ocular exposure, 2010 Asis-Pacific Radio
Science Congerence, (Toyama, '10.09).

－ 145 －

－ 146 －Affiliated Institution

9050

Center for FDD-MB

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Researcher

YUDITIYA Purwosunu fetal medicine, DNA medicine.

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology

Publications
Originals
9050B001(N.Ba Trung), M.Saito, H.Takabayashi, P.Hung Viet, E.Tamiya, Y.Takamura: Multi-chamber PCR chip with simple
liquid introduction utilizing the gas permeability of polydimethylsiloxane, Sens. Actuators. B. Chem., 149:284-290,
2010.

Presentations at Conference
International Conference (Key Note Lecture)
9050G001

H.Takabayashi: FDD-MB 3.0 System, 6th World Congress of Perinatal Medicine, (Indonesia, '10.03).

－ 147 －

9030

North Noto Institute of Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Senior Assistant Professor

NOMURA Koji

Geriatrics, Circulation

Assistant
Professor(Additional Post)

KITAMURA Kenji

Hip surgery

Keywords of Research
The Elderly, Rural Medicine, Medical Needs

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

Publications
Originals
9030B001

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

Presentations at Conference
International Conference (Presentations)
9030I001

H.Murai, T.Nakahashi, H.Nakamura, W.Arayama, T.Higashikawa, M.Atsumi, K.Iwai, S.Morimoto: The advantage ofhigh-salt tube mutriton for the elderly patients with acute disease, 32nd ESPEN Congress, (Nice-France, '10.09)，
Abstracts of the32nd ESPEN Congress, 5：ABS-296(Suppl.), 2010.

－ 148 －

Himi Municipal Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

TAKASHIMA Shigeki

Surgery of Digestive Diseases, Coloproctological Surgery.

Professor

IZUMI Youichi

Hypertension, Endocrinology.

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery.

Professor

KIGOSHI Toshikazu

intracellular signaling of hormones, aldosterone secretion.

Professor

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease.

Associate Professor

KUZAWA Yutaka

Cardio Vascular Surgery.

Associate Professor

KURAUCHI Manabu

Cerebro vascular disease.

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery.

Associate Professor

URATA Kazuhiko

Obstetrics and gynecology.

Associate Professor

MIURA Motohiro

Circulatory organs internal medicine.

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases.

Senior Assistant Professor

SAITO Atsushi

Nephrology.

Senior Assistant Professor

TAKATA Hideo

Orthopaedic Surgery.

Senior Assistant Professor

WATANABE Kimimasa Orthopaedic Surgery.

Senior Assistant Professor

YAMASHITA Naohiro Circulatory organs internal medicine.

Senior Assistant Professor

TANAKA YumikoSenior Assistant Professor

HASEGAWA Taisuke Surgery of hepatobiliary diseases.

Senior Assistant Professor

TSUCHIDA Maki

Ophthalmology.

Assistant Professor

MUKAI Hirokado

Oncology Surgery.

Assistant Professor

HASEGAWA Masayuki regional medicine.

Assistant Professor

NAKANAMI Aki

Orthopaedic Surgery.

Assistant Professor

KUSABA Eizo

neurosurgery.

Assistant Professor

MIZUNO Takuro

regional medicine.

Assistant Professor

SAKAI Junta

Geriatrics, Gastroenterology.

Assistant Professor

MUKAIYAMA
Hirotaka

Pediatrics.

Surgery of colorectal cancer.

Publications
Originals
9100B001

Z.Shijie, J.Moriya, J.Yamakawa, R.Chen, T.Takahashi, H.Sumino, T.Nakahashi, K.Iwai, S.Morimoto, N.Yamaguchi,
T.Kanda: Mao-to prolongs the survival of and reduces TNF-α expression in mice with viral myocarditis, Evid
Based Complement Alternat Med, 7:341-349, 2010.

－ 149 －

Case Reports
9100D001

K.Konishi, A.Saito, K.Ishigami, M.Fukura, M.Hasegawa, N.Yamashita, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypoglycemia in elderly diabetes mellitus-free patients :Case reports and a review of literature, J.
Kanazawa. Med. Univ., 35:13-15, 2010.

9100D002

K.Ishigami, N.Yamashita, K.Konishi, A.Saito, M.Fukura, M.Hasegawa, T.Kanda, T.Ito, T.Kigoshi, Y.Izumi,
N.Takekoshi: Hypernatremia, rhabdomyolysis and acute renal failure, J. Kanazawa. Med. Univ., 35:68-69, 2010.

9100D005

S.Yoshitani, T.Ohnishi, Y.Tomita, Y.Ohno, K.Hosokawa, M.Yokoi, H.Funaki, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: A case report of pathologically complete response with chemo-radiation for rectal cancer,
Cancer & chemotherapy, 37:2632-2634, 2010 (in Japanese) .

9100D006

H.Funaki, T.Ohnishi, Y.Ohno, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: A case of AGC with pCR after preoperative chemotherapy including S-1 plus cisplatin,
Cancer & chemotherapy, 37:2430-2432, 2010 (in Japanese) .

Others
9100F001

R.Chen, F.Liang, K.Ishigami, T.Kanda, L.Zeng, A.Saito, M.Hasegawa, N.Yamashita, T.Itoh, T.Kigoshi, Y.Izumi,
N.Takekoshi, S.Morimoto: Clinical risk factors in regional brain ischemia using single photon emission computed
tomography, J. Am. Geriatr. Soc., 58：1411-1412, 2010.

Presentations at Conference
International Conference (Presentations)
9100I001

S.Yoshitani, K.Hosokawa, T.Kosaka: Identification of risk factors for stage Ⅱ colorectal cancer in patients withrecurrence, XXIV ISUCRS Biennial Congress, (Seoul, '10.03)，XXIV ISUCRS Biennial Congress Abstracr Book,
233-234, 2010.

9100I002

A.Yamaya, J.Huang, T.Fukunaga, S.Shinomiya, S.Kitadate, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, T.Oikawa,
K.Nakagawa, K.Tsuchihara, M.Iguchi, M.Takahashi, K.Osanai, H.Toga: Peripheral airway resistance determinedwith the interruption technique in COPD patients, American Thoracic Society 2010 International Conference, (New
Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2118, 2010.

9100I003

M.Saito, J.Huang, S.Shinomiya, S.Kitadate, Y.Takahara, A.Yamaya, K.Kojima, Y.Fujimoto, T.Oikawa, K.Nakagawa,
T.Fukunaga, K.Tsuchihara, M.Iguchi, K.Osanai, H.Toga: Upper airway function assessed with negative expiratory
pressure technique during wakefulness in patients with obstructive sleep apnea, American Thoracic Society 2010
International Conference, (New Orleans, '10.05)，Am. J. Respir. Crit. Care Med., 181:A2209, 2010.

9100I004

T.Kosaka, Y.Tomita, T.Onishi, Y.Ono, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, S.Kinami, K.Omote,
N.Ueda, Y.Nakano: Neoadjuvant chemotherapy with a combination of S-1 and cisplatin in nonresectable advanced
gastric cancer, The 17th Czech-Japan Surgical Symposium, (Kanazawa, '10.06).

9100I005

K.Omote, S.Kinami, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda, Y.Nakano, T.Kosaka: Laparoscopic
surgery for early gastric cancer -Experience in our institute-, The 17th Czech-Japan Surgical Symposium,(Kanazawa, '10.06).

9100I006

S.Kinami, T.Kosaka, S.Yoshitani, K.Omote, N.Ueda, Y.Nakano, S.Fushida, T.Fujimura, T.Ohta: The clinicaladvantage of the sentinel node biopsy for early gastric cancer in conducting the pylorus preserving procedure, The
17th Czech-Japan Surgical Symposium, (Kanazawa, '10.06).

9100I007

K.Omote, S.Kinami, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda, Y.Nakano, T.Kosaka: Laparoscopic
surgery for early gastric cancer, ESMO conference: 12th World congress on gastrointestinal cancer, (Barcelona,'10.06)，Annals of Oncology, 21 suppl.6: vi88, 2010.

－ 150 －

9100I008

K.Omote, S.Kinami, T.Ohnishi, Y.Tomita, Y.Ohno, K.Hosokawa, M.Yokoi, H.Funaki, S.Yoshitani, N.Ueda,
Y.Nakano, T.Kosaka: Laparoscopic gastrectomy for early gastric cancer, 9th International Conference of the Asian
Clinical Oncology Society, (Gifu, '10.08).

9100I009

H.Funaki, T.Ohnishi, Y.Ohno, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, S.Kinami, K.Omote, N.Ueda,
Y.Nakano, T.Kosaka: Pathological complete response in advanced gastric cancer Stage IV after preoperative
chemotherapy including S-1 plus Cisplatin -- Report of a case, 9th International Conference of the Asian ClinicalOncology Society, (Gifu, '10.08).

9100I010

S.Kinami, T.Kosaka, T.Onishi, Y.Tomita, K.Hosokawa, M.Yokoi, S.Yoshitani, K.Omote, N.Ueda, Y.Nakano: The
application of Liga-Sure precise to the lymph node dissection in gastric cancer surgery, 9th International
Conference of the Asian Clinical Oncology Society, (Gifu, '10.08).

－ 151 －

Kanazawa Medical University
Research Activities and Publications 2010
Published December, 2011
Issuer: Shogo Katsuda
Editer: Hideaki Nakagawa
Publishing office: Kanazawa Medical University Publication office
1-1 Daigaku,Uchinada-machi,Kahoku-gun,Ishikawa-ken,Japan,920-0293
Tel +81 76 286 2211(Representative)

Printing office: TANAKA&SHOBUNDO GRAPHIC ART Co.LTD.

－ 152 －