Kanazawa Medical University
Research Activities and Publications
VOL.272015

Kanazawa Medical University

INDEX
Code

Depaertment

Page

Code

Depaertment

Page

Basic Medical Science
0100

Department of Anatomy Ⅰ・・・・・・・・

1

0460

Department of Pediatric Surgery

・・・・・・・・

70

0110

Department of Anatomy Ⅱ・・・・・・・・

2

0470

Department of Ophthalmology

・・・・・・・・

72

0120

Department of Physiology Ⅰ・・・・・・・・

30475

Department of Otorhinolaryngology

・・・・・・・・

76

0130

Department of Physiology Ⅱ・・・・・・・・

50485

Department of Head and Neck Surgery

・・・・・・・・

78

0140

Department of Biochemistry Ⅰ・・・・・・・・

70490

Department of Dermatology

・・・・・・・・

79

0150

Department of Biochemistry Ⅱ・・・・・・・・

80500

Department of Urology

・・・・・・・・

81

0160

Department of Pharmacology

・・・・・・・・

90510

Department of Obstetrics and Gynecology

・・・・・・・・

83

0520

・・・・・・・・

85

Medicine・・・・・・・・

87

Department of Emergency Medicine

・・・・・・・・

88

0170

Department of Pathology Ⅰ・・・・・・・・

110180

Department of Pathology Ⅱ・・・・・・・・

13

Department of Anesthesiology andPerioperative Medicine

0190

Department of Microbiology

・・・・・・・・

15

0200

Department of Immunology

・・・・・・・・

16

0210

Department of Medical Zoology

・・・・・・・・

17

0550
0570

Department of Community Medicine

・・・・・・・・

89

・・・・・・・・

180575

Department of Gastroenterological Endoscopy

・・・・・・・・

90

0580

Department of Oral and Maxillofacial Surgery

・・・・・・・・

92

Medicine・・・・・・・・

20

Department of Epidemiology and Public Heaｌｔｈ・・・・・・・・

21

0220

Department of Pathology and Laboratory
edicine

0230

0240

Department of Social and Environmental

0540

Department of Physical and Rehabilitation

University Hospital

0250

Department of Legal Medicine

・・・・・・・・

24

0635

Hepatology

・・・・・・・・

93

0260

Department of Medical Education

・・・・・・・・

25

0675

Health Evaluation Center・・・・・・・・

95

0300

Department of Cardiology

・・・・・・・・

26

7100

Department of Life Science・・・・・・・・

98

0310

Department of Respiratory Medicine

・・・・・・・・

28

7200

Department of Advanced Medicine

・・・・・・・・

102

0320

Department of Gastroenterology

・・・・・・・・

30

7310

Division of Innovative Research・・・・・・・・

106

0330

Department of Nephrology

・・・・・・・・

32

7320

Division of Vision Research for Environmental
・・・・・・・・

108

7340

Division of Anticipatory Molecular Food Science・・・・・・・・

112

7350

Division of Systems Bioscience for Drug

Proteins

・・・・・・・・

113

Research Support Cente・・・・・・・・

115

Clinical Medicine

Medical Research Institute

0340

Department of Diabetology and Endocrinology

・・・・・・・・

35

0350

Department of Hematology and Immunology

・・・・・・・・

38

0360

Department of Neurology

・・・・・・・・

41

0363

Department of Medical Oncology

・・・・・・・・

44

0366

Department of Infectious Diseases

・・・・・・・・

46

Healthand echnology

Discovery Based on Intrinsically Disordered

0368

Department of General Internal Medicine

・・・・・・・・

47

0370

Department of Geriatric Medicine

・・・・・・・・

49

0380

Department of Pediatrics

・・・・・・・・

50

0390

Department of Neuropsychiatry

・・・・・・・・

52

0400

Department of Radiology

・・・・・・・・

54

8010

Fundamental Nursing

・・・・・・・・

118

0410

Department of Cardiovascular Surgery

・・・・・・・・

56

8040

Adult Nursing

・・・・・・・・

120

0415

Department of Thoracic Surgery

・・・・・・・・

57

8050

Gerontological Nursing

・・・・・・・・

121

0420

Department of General and Digestive Surgery

・・・・・・・・

59

8060

Pediatric Nursing

・・・・・・・・

122

0430

Department of Orthopedics Surgery

・・・・・・・・

62

8070

Maternity Nursing・Midwifery

・・・・・・・・

123

0440

Department of Neurosurgery

・・・・・・・・

65

8080

Public Health Nursing

・・・・・・・・

124

8085

Psychiatric and Mental Health Nursing

・・・・・・・・

125

・・・・・・・・

68

8090

Home Care Nursing

・・・・・・・・

126

8100

Medical Science・・・・・・・・

127

0450

Department of Plastic and Reconstructive
Surgery

7400

School of NursingCodeDepaertment

Page

Department of General Education
8610

Natural Science・・・・・・・・

129

8620

Human Science・・・・・・・・

131

Medicine・・・・・・・・

133

FDD-MB Center・・・・・・・・

134

・・・・・・・・

135

Affiliated Institution
9030

9050

Northern Noto Institute of Community

Himi Municipal Hospital
9100

Himi Municipal Hospital

Code

Depaertment

Page

Basic Medical Science

0100

Department of Anatomy Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

HATTA Toshihisa

developmental biology, neuroscience

Professor

HIGASHI Nobuaki

macroscopic anatomy, embryology

Senior Assistant Professor

SHIMADA Hiroki

Medical science of free radical

Keywords of Research
exo utero development, embryo, fetus, neurogenesis, cytokines, growth factors, hormones, stereology, ELISA, antioxidant,
apoptosis, bcl-2, enzyme cytochemistry, electron microscopy, furanonaphthoquinone, free radical, immunohistochemistry,human macroscopic anatomy, mitochondria, NADH-quinone oxidoreductase, paraquat, reactive oxygen species, superoxide,
scavenger, VDAC, anomaly of muscles and blood vessels

Outline of Research
1. Studies on the feto-maternal signal transductions contributing to the fetal development via neuro-immune-endocrine
network.
2. Cytochemical study of the cytotoxicity by reactive oxygen species.
3. Biological functions of VDAC family proteins.
4. Macroscopic studies on the variations of muscles and blodd vessels.
5. Comparative anatomical studies on the brain evolution

Publications
Originals
0100B001(N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous
tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015.

0100B002

E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura,
T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.

0100B003

T.Tsukada, E.Simamura, H.Shimada, T.Arai, N.Higashi, T.Akai T, H.Iizuka, T.Hatta:The suppression of maternalfetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in
mice, PLoS One, 10:6;e0129011, 2015.

1

0110

Department of Anatomy Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

HONMA Satoru

gross anatomy

Senior Assistant Professor

SONOMURA Takahiro

Senior Assistant Professor

KOMINAMI Rieko

Senior Assistant Professor

YASUTAKA Satoru

Neuroanatomy, immunohistochemistry, electron microscopy, 3D
reconstruction
immunocytochemistry, pituitary, cell proliferation, electron
microscopy
gross anatomy, central nervous system

Keywords of Researcharthrology, osteology, clinical anatomy, development, lymphatic vessels, muscle, innervation, nerve, pituitary, ACTH, LH,
GH, ontogenesis, immunocytochemistry, bromodeoxyuridine, proliferation, electron microscopy, rat, PCNA, Neuroanatomy,
FIB/SEM, BMI, gustatory,

Outline of Research
Theme of researches
1)Human gross anatomy
2)Neural network of the basal ganglia
3）Circuit of gustatory in the central nervous system
4）Anatomical study of brain white matter by using fiber dissection technique5）Immuno-histochemical study of pituitary gland

Publications
Originals
0110B001(N.Nakata), T.Wakayama, T.Sonomura, S.Honma, T.Hatta, S.Iseki:Three-dimensional structure of seminiferous
tubules in the adult mouse, Journal of Anatomy, 227:5;686-694, 2015.

0110B002(T.Tsukahara), M.Masuhara, H.Iwai, T.Sonomura, T.Sato:Repeated stress-induced expression pattern alterationsof the hippocampal chloride transporters KCC2 and NKCC1 associated with behavioral abnormalities in female
mice, Biochemical and Biophysical Research Communications, 465:1;145-151, 2015.

0110B003(H.Iwai), E.Kuramoto, A.Yamanaka, T.Sonomura, M.Uemura, T.Goto:Ascending parabrachio-thalamo-striatal
pathways: Potential circuits for integration of gustatory and oral motor functions., Neuroscience, 294:1-13, 2015.

2

0120

Department of Physiology Ⅰ

Faculty
Title

Name

Field of Specialization

Professor

KATO Nobuo

Brain Science

Senior Assistant Professor

TAJIMA Nobuyoshi

molecular physiology

Assistant Professor

UCHIUMI Osamu

Neuroscience

Keywords of Research
central nervous system, neurophysiology, electrophysiology, immunohistochemistry, field potential, propagating signal,
horizontal propagation, oscillation, rat, guinea pig, slice preparation, in vitro, voltage-sensitive dye, subdivision,
intracellular recording, intracellular staining, Neuroethology, Behavioral test battery, BK channel

Outline of Research
The brain is often regarded as a microcosmos, which contains more than a million neurons. Each neuron, however, is not amere stardust. A single neuron integrates many inputs thereunto, so as to determine whether the output signal is released
or not. Neurons are connected to each other by synapses to build neuron network, which underlies brain function. Our
primary research interest is to elucidate, in molecular terms, how one or more neurons are able to regulate neuron
excitability and synaptic efficiency. In particular, we are interested in studying in vitro how the versatile intracellularmessenger calcium ion mediates a number of signals differentially, thereby achieving adequate regulation of synaptic
efficiency and neuron excitability.

Publications
Originals
0120B001

Y.Zhang, F.Wang, X.Luo, L.Wang, P.Sun, M.Wang, Y.Jiang, J.Zou, O.Uchiumi, R.Yamamoto, T.Sugai,
K.Yamamoto, N.Kato:Cognitive improvement by photic stimulation in a mouse model of Alzheimer's disease,
Current Alzheimer Research, 12:9;860-869, 2015.

0120B002

P.Sun, Q.Zhang, Y.Zhang, F.Wang, L.Wang, R.Yamamoto, T.Sugai, N.Kato:Fear conditioning suppresses largeconductance calcium-activated potassium channels in lateral amygdala neurons., Physiology & Behavior, 138:279284, 2015.

0120B003

L.Wang, H.Kang, Y.Li, Y.Shui, R.Yamamoto, T.Sugai, N.Kato:Cognitive recovery by chronic activation of thelarge-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease,
Neuropharmacology, 92:8-15, 2015.

0120B004

T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic
modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.

0120B005

Y.Shui, L.Wang, X.Luo, O.Uchiumi, R.Yamamoto, T.Sugai, N.Kato:Homer1a disruption increases vulnerability to
predictable subtle stress normally sub-threshold for behavioral changes, Brain Research., 1605:70-75, 2015.

0120B006

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.

0120B007P Sun, Q Zhang, Y Zhang, F Wang, R Chen, R Yamamoto, N Kato:Homer1a-dependent recovery from depressionlike behavior by photic stimulation in mice, Physiology & Behavior, 147:334-341, 2015.

3

0120B008

F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial
learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.

0120B009

Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to
cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.

Presentations at Conference
International Conference (Synposium)
0120H001

K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.

International Conference (Presentations)
0120I001

N.Kato:Behavioral recovery by transcranial magnetic stimulation in a mouse model of depression is dependent on
Homer1a expression., 1st International Brain Stimulation Conference, Singapore, 2015.

0120I002

N.Kato,J.Zou:Deficits in Morris water maze performance exacerbated by minimal neocortical injury in a mousemodel of Alzheimer's disease, Neuroscience 2015, Chicago, 2015.

4

0130

Department of Physiology Ⅱ

Faculty
Title

Name

Field of Specialization

Professor

SHIBAMOTO
Toshishige

Circulatory Physiology

Professor

KURATA Yasutaka

Cardiac Electrophysiology

Senior Assistant Professor

TANIDA Mamoru

Circulatory Physiology

Senior Assistant Professor

WAN Mofei

Circulatory Physiology

Assistant Professor

KUDA Yuichi

Circulatory Physiology

Keywords of Researchphysiology, hepatic circulation, pulmonary circulation, sympathetic nervous system, isolated perfused liver, circulatory
shock, triple vascular occlusion pressure, pulmonary edema, microcirculation, capillary pressure, vascular resistance
distribution, pulmonary circulation, triple vascular occlusion pressure, cardiac electrophysiology, ion channels, pacemakermechanisms, cardiac arrhythmias, biological pacemaker, mathematical modeling, bifurcation analysis, nonlinear dynamics,
computer simulation, smooth muscle, vascular electrophysiology, arthery, vein

Outline of Research
Our works widely cover the area of cardiovascular physiology. We are particularly interested in the mechanisms ofregulations of hepatic circulation under normal and anaphylactic conditions, and the mechanisms of cardiac automaticity andarrhythmias as well as their regulations. Using liver perfusion system for rats, we recently elucidated the effects ofvasoconstrictive lipid mediators such as PAF on the vascular resistance and oxygen consumption, the attenuating effect ofNO on anaphylactic hepatic venoconstriction, and the decreased oxygen consumption during hepatic anaphylaxis. We also
explored the inhibitory effect of angiotensin II on inward rectifier K+ currents via AT1 receptors in rat atrial myocytes, andthe possible roles of pacemaker currents in robust pacemaking and driving of biological pacemakers.

Publications
Originals
0130B001

M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga:Pulmonary vascular andairway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , Journal of cardiovascularpharmacology, 65:4;325-334, 2015.

0130B002(Y.Konishi), Y.Koosaka, R.Maruyama, K.Imanishi, K.Kasahara, A.Matsuda, S.Akiduki, Y.Hishida, Y.Kurata,
T.Shibamoto, J.Satomi, M.Tanida:l-Ornithine intake affects sympathetic nerve outflows and reduces body weight
and food intake in rats. , Brain Research Bulletin, 111:48-52, 2015.

0130B003(R.Endo), Y.Kurata, T.Notsu, P.Li, K.Morikawa, T.Kondo, K.Ogura, J.Miake, A.Yoshida, Y.Shirayoshi,
H.Ninomiya, K.Higaki, M.Kuwabara, K.Yamamoto, Y Inagaki, I.Hisatome:Stabilization of Kv1.5 channel protein by
the inotropic agent olprinone., European Journal of Pharmacology, 765:488-494, 2015.

0130B004(N.Maharani), YK.Ting, J.Cheng, A.Hasegawa, Y.Kurata, P.Li, Y.Nakayama, H.Ninomiya, N.Ikeda, K.Morikawa,
K.Yamamoto, N.Makita, T.Yamashita, Y.Shirayoshi, I.Hisatome:Molecular mechanisms underlying urate-induced
enhancement of Kv1.5 channel expression in HL-1 atrial myocytes., Circulation Journal, 79:12;2659-2668, 2015.

5

0130B005

M.Tanida, N.Yamamoto, DA.Morgan, Y.Kurata, T.Shibamoto, K.Rahmouni:Leptin receptor signaling in the
hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activatedprotein kinase., The Journal of Neuroscience, 35:2;474-484, 2015.

0130B006

M.Tanida, H.Gotoh, N.Yamamoto, M.Wang, Y.Kuda, Y.Kurata, M.Mori, T.Shibamoto:Hypothalamic nesfatin-1
stimulates sympathetic nerve activity via hypothalamic ERK signaling. , Diabetes, 64:11;3725-3736, 2015

0130B007T.Shibamoto, Y.Kuda, M.Tanida, M.Wang, Y.Kurata:Exercise attenuates ischemia-reperfusion injury of
nonalcoholic fatty liver of OLETF rat., Journal of Gastroenterology, Pancreatology & Liver Disorders, 2:2;1-6,
2015.

0130B008(P.Li), Y.Kurata, N.Maharani, E.Mahati, K.Higaki, A.Hasegawa, Y.Shirayoshi, A.Yoshida, T.Kondo, Y.Kurozawa,
K.Yamamoto, H.Ninomiya, I.Hisatome:E3 ligase CHIP and Hsc70 regulate Kv1.5 protein expression and function in
mammalian cells., Journal Molecular and Cellular Cardiology, 86:138-146, 2015.

0130B009

T.Shibamoto, M.Wang:The effect of tolvaptan, a vasopressin V2 receptor antagonist, on the portal venous
pressure in rats., Japanese Pharmacology & Therapeutics, 43:9;1283-1294, 2015.

0130B010(S.Yagi), M.Tanida, J.Satomi:Possible role of afferent autonomic signals in abdominal organs in anorexic andcardiovascular responses to nicotine injection in rats., NeuroReport, 26:8;445-449, 2015.

0130B011(Y.Shibasaki), A.Hayata-Takano, K.Hazama, T.Nakazawa, N.Shintani, A.Kasai, K.Nagayasu, R.Hashimoto,
M.Tanida, T.Katayama, S.Matsuzaki, K.Yamada, M.Taniike, Y.Onaka, Y.Ago, JA.Waschek, K.Köves, D.Reglödi,
A.Tamas, T.Matsuda, A.Baba, H.Hashimoto:Atomoxetine reverses locomotor hyperactivity, impaired novel object
recognition, and prepulse inhibition impairment in mice lacking pituitary adenylate cyclase-activating polypeptide.,
Neuroscience, 297:95-104, 2015.

0130B012

M.Wang, T.Shibamoto, Y.Kuda, M.Tanida, Y.Kurata:Systemic vasoconstriction modulates the responses of
pulmonary vasculature and airway to vasoconstrictors in anesthetized rats., Experimental Lung Research,
41:6;324-334, 2015.

Others0130F001

N.Okumura, M.Tanida, A.Niijima, N.Tsuruoka, Y.Kiso, Y.Horii, K.Nagai:Carnosine and the control of blood
glucose, Food and Nutritional Components in Focus, 8:257-276, 2015.

Presentations at Conference
International Conference (Presentations)
0130I001

S.Shinomiya, M.Nojiri, K.Nakase, R.Kato, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa,S.Mizuno, K.Osanai, T.Shibamoto, H.Toga:Nitric oxide and β2-adrenoceptor activation attenuate pulmonary
vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice, Pulmonary vascular research
institute, China, 2015.

6

0140

Department of Biochemistry Ⅰ

Title

Name

Field of Specialization

Professor

IWABUCHI Kuniyoshi Molecular biology, DNA repair, p53-binding proteins

Assistant Professor

SAKASAI Ryo

DNA damage response induced by anti-cancer drugs

Assistant Professor

SUNATANI Yumi

Function of DNA damage repair protein

Assistant Professor

MATSUI Tadashi

Molecular biology, DNA repair, p53-binding proteins

Faculty

Keywords of Research
ionizing radiation, DNA double-strand break, checkpoint, DNA repair, cell cycle, p53, 53BP1, signal transduction

Outline of Research
Ionizing radiation (IR) induces a variety of DNA lesions, including DNA double-strand breaks (DSBs). DNA damages
activate cell-cycle checkpoints, which monitor DNA damage and transduce signals to coordinate repair and cell cycle
progression. Using the yeast two-hybrid system, we have identified two cellular proteins, designated 53BP1 and 53BP2,that interact with the tumor suppressor p53. After exposure of cells to IR, 53BP1 rapidly accumulates at sites of DNA
DSBs, suggesting that 53BP1 is involved in cellular responses to DNA DSBs. Our goal is to know functions of 53BP1 incellular responses to DNA DSBs.

Publications
Originals
0140B001

Y.Matsui, Y.Sunatani, N.Hayashi, K.Okino, Y.Okushi, K.Mukai, H.Adachi, H.Yamaya, K.Iwabuchi,
H.Yokoyama:DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts, Clinical andExperimental Nephrology, 20:3;479-488, 2015.

Reviews
0140C001

R.Sakasai, K.Iwabuchi:The distinctive cellular responses to DNA strand breaks caused by a DNA topoisomerase Ⅰ
poison in conjunction with DNA replication and RNA transcription, Genes & genetic systems, 90:4;187-194, 2015.

Presentations at Conference
International Conference (Presentations)
0140I001

Y.Sunatani, M.K.Sharma, R.P.Kamdar, T.Matsui, R.Sakasai, M.Hashimoto, Y.Matsumoto,K.Iwabuchi:Phosphorylation-mediated Regulation of Apoptosis By NHEJ-protein XRCC4, 15th International
Congress of Radiation Research, Kyoto, 2015.

0140I002

R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi:Ubiquitin-dependent Activation of DNA-PKcs Leads
to Chromosomal Aberration in Response to One-ended DNA Double Strand Breaks, 15th International Congress ofRadiation Research, Kyoto, 2015.

0140I003

Y.Matsui, Y.Sunatani, K.Iwabuchi, H.Yokoyama:DNA double strand breaks accelerated collagen type VI secretionof glomerular endothelial cells, ERA-EDTA Congress in Amsterdam The Netherlands, London, 2015.

7

0150

Department of Biochemistry Ⅱ

Title

Name

Field of Specialization

Professor

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate Professor

YOSHITAKE Yoshino

MicroRNA involved in angiogenesis, Functions of FGF-2 binding
proteinSenior Assistant Professor

IKEDA Takayuki

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Assistant Professor

YOSHITOMI Yasuo

Molecular mechanisms of angiogenesis and vasculogenesis

Faculty

Keywords of Research
growth factor, fibroblast growth factor, vascular endothelial growth factor, growth factor receptor, VEGF receptor,
cytokines, autocrine/paracrine, angiogenesis, neuro-vascular interaction, tumor growth, diabetic vascular complications,endothelial cell, smooth muscle cell, chondrocyte, osteoblast, RNA interference, microRNA, alternative mRNA processing,centrosome, microtubule stabilizing protein, collagen, collagen tripeptide, hydroxyapatite, spermatogenesis, androgen
receptor,

Outline of Research
1. Mechanisms of alternative pre-mRNA splicing and 3’-end processing
2. Cellular and molecular mechanisms in angiogenesis
3. Screening and identification of genes and microRNAs involved in neuro-vascular interaction
4. Molecular mechanisms in development of diabetic vascular complications

Publications
Originals
0150B001

E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura,
T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.

0150B002

S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused
by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015

Presentations at Conference
International Conference (Presentations)
0150I001

H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.

8

0160

Department of Pharmacology

Faculty
Title

Name

Professor

NISHIO Matomo

Professor(Additional Post)
Senior Assistant Professor

Field of Specialization

Electrophysiological and pharmacological study of excitable and nonexcitable cells, Pharmocology of cardiovascular drugs
Kinetics of NO(nitric oxide)-related compounds in cardiovascular
ISHIBASHI Takaharu
systemElectrophysiology and behavioural pharmacology in central and
MASUOKA Takayoshi
periphenal nervous system

Senior Assistant Professor

YOSHIDA Junko

Pharmacology in cardiovascular system, Cancer chemotherapy

Assistant Professor

IMAIZUMI Noriko

Pharmacology of cardiovascular drugs, Kinetics of NO-related
compounds in cardiovascular systems, Cancer chemotherapy

Keywords of Research
electropharmacology, electrophysiology, ionic channel, patch clamp, excitable membrane, cardiovascular system, ischemic
disease, marine toxin, ATP-sensitive K+ channel, store-operated Ca2+ channel, Ca2+ imaging, coronary circulation, nitricoxide, hemodynamics, nitric oxide-releasing vasodilators, nitrosothiols, signal transduction, anti-tumor drug, proliferation,
cell biology, hippocampal synapses, muscarinic acetylcholine receptorrvous system, peripheral sensory neuron, autonomic
neuron, central ne, metabotropic glutamate receptor, receptorology,

Outline of Research
１ Electrophysiological and pharmacological study on the regulatory mechanisms of excitable and non-excitable cells
２ Signaling mechanisms of bioactive substances
３ Electropharmacology of the drugs acting on the cardiovascular system
４ Pharmacological study of the ischemic cardiomyocytes
５ Kinetics of NO(nitric oxide)-related compounds in cardiovascular system
６ Pharmacological and electrophysiclogical studies on the neurophysiological mechanisms of memory and pain regulation

Publications
Originals
0160B001

T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic
modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.

Reviews
0160C001

T.Masuoka, T.Ishibashi, M.Nishio:Biphasic modulation of noxious heat sensitivity in sensory neurons by peripheral
metabotropic glutamate receptors, Inflammation and Cell Signaling, 2:602, 2015.

0160C002

J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio:Ca2+ Signalimg molecules STIM1/Orail and Cancer,
Journal of Kanazawa Medical University, 40:2・3;69-77, 2015.

9

Presentations at Conference
International Conference (Presentations)
0160I001(J. Gallar),T.Masuoka,C.Belmonte:Effects of amitriptyline on the spontaneous and stimulus-evoked activity ofcorneal cold-sensitive nerve terminals, Association for Ocular Pharmacology and Therapeutics 2015, Charleston,
2015.

0160I002

T.Masuoka, J.Gallar, C.Belmonte:Effects of sodium channel blocker amitriptyline on the spontaneous and stimulusevoked activity of corneal cold-sensitive nerve terminals in intact and tear-deficit guinea-pig eye, The association
for Research in vision and Ophtalmology 2015, Denver, 2015.

10

0170

Department of PathologyⅠ

Faculty
Title

Name

Field of Specialization

Professor

KIYOKAWA Etsuko

Experimental Pathology, Fluorescent Imaging

Assistant Professor

TAKEDA Haruna

Mouse model for carcinogenesis、Two-photon microscopy imaging

Assistant Professor

AIKAWA Akane

Basic medical science

Keywords of Researchin vivo imaging, FRET, polarity, cancer, lens epithelial cell, sphingomyelin, epithelial regeneration,

Outline of Research
We observed signal transduction pathways in mice and cells expressing FRET biosensors, to understand cancer
development and invasion/metastasis, and epithelial regeneration.. We also develop the system to manipulate cell signaling
to understand the molecular mechanisms for morphology Focusing on the lens epithelial cells, we are now investigating rolesof DOCK5, an activator for Rac1, in the epithelial morphology and maintenance.

Publications
Originals
0170B001(Y.Kumagai), H.Naoki, E.Nakasho, Y.Kamioka, E.Kiyokawa, M.Matsuda:Heterogeneity in ERK activity as
visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice, Oncogene.,
34:8;1051-1057, 2015.

0170B002

H.Takeda, Z.Wei, H.Koso, A.G.Rust, C.C.K.Yew, M.B.Mann, J.M.Ward, D.J.Adams, N.G.Copeland,
N.A.Jenkins:Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor
progression, Nature genetics, 47:142-150, 2015.

0170B003

H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.

Presentations at Conference
International Conference (Key Note Lecture)
0170G001

E.Kiyokawa:FRET imaging in organoids and mice., 2015 CRI Cancer Symposium, Hwasun Kumho, 2015.

0170G002

E.Kiyokawa:FRET imaging in organoids and mice, 2015 Biophysical Society Thematic Meeting in Taiwan New
Biological Frontiers Illuminated by Molecular Sensors and Actuators, Taipei, 2015.

0170G003

E.Kiyokawa:FRET imaging in organoids and mice., The International Chemical Congress of Pacific Basin Societies
2015, Honolulu, 2015.

11

International Conference (Presentations)
0170I001

H.Takeda, H.Yoshizaki, E.Kiyokawa:In vivo imaging using a two-photon microscope in the mouse intestine,
International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular
Activities, Kyoto, 2015.

0170I002

T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin
expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision andOphthalology, Denver, 2015.

0170I003

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lensepithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision andOphthalology, Denver, 2015.

0170I004

A.Aikawa, E.Kiyokawa:In vivo fluorescent imaging of colon cancer metastasis, The Second International Meetingfor Epithelial Tubulology, Sapporo, 2015.

0170I005

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

0170I006

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lensepithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.

0170I007T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelialmesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.

12

0180

Department of PathologyⅡ

Faculty
Title

Name

Field of Specialization

Professor

UEDA Yoshimichi

Bone and soft tissue tumor, Pulmonary pathology

Associate Professor

SATO Katsuaki

Diagnostic pathology of tumor

Assistant Professor

SHIMASAKI Miyako

molecular pathology of the lung cancer

Keywords of Researchatherosclerosis, extracellular matrix, lung carcinoma, bone and soft tissue tumor, metastasis, invasion, apoptosis, diagnostic
histopathology, cardiomyopathy, matrix metalloproteinase, bone tumor, molecular genetics, molecular pathology, neuronal
death, nitric oxide synthase, angiogenesis, HMGI-C, Fas/Fas ligand, NFκB,

Outline of Research
1. Study on the functional gene networks involved in the progression of human lung cancer, especially regarding epithelialmesenchymal transition of cancer cells, in order to establish novel molecular targets for the treatment. We are analyzing
gene expression profiling data bioinformatically by means of ITP, one of the largest data-base for functional gene
network/pathway analysis.
2. Molecular pathological diagnosis by FISH using probes origination from BAC clones and RT-PCR methods.
3. Study on the pathogenesis of atherosclerosis, particularly from the aspect of extracellular matrix (ECM). The major
subjects are: 1) collagens in human atherosclerosis, 2) cellular interactions and growth regulatory molecules, and 3) ECM
degradation and matrix metalloproteinases.

Publications
Originals
0180B001

L.Tang, Y.Sakai, Y.Ueda, S.Katsuda:Effects of oral administration of tripeptides derived from type I collagen(collagen tripeptide) on atherosclerosis development in hypercholesterolemic rabbits, Journal of Bioscience andBioengineering, 119:5;558-563, 2015.

0180B002

S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused
by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.

0180B003

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions:comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015.

0180B004

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.

0180B005

T.Ichiseki, S.Ueda, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:Age-related changes of mitochondrialtranscription factor a expression in rotator cuff degeneration, American Journal of Translational Research,
7:10;2099-2104, 2015.

13

Case Reports
0180D001

I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Miyazawa, K.Sato:A
case of mucinous tubular and spindle cell carcinoma, Japanese journal of urological surgery, 28:1;99-102, 2015.

14

0190

Department of Microbiology

Faculty
Title

Name

Field of Specialization

Associate Professor

HIMEDA Toshiki

Neurovirology

Keywords of Research
Theiler's murine encephalomyelitis virus, central nervous system, demyelination, persistent infection, multiple sclerosis,

Outline of ResearchStudies on pathomechanism of virus induced demyelination

15

0200

Department of Immunology

Faculty
Title

Name

Field of Specialization

Professor

NAKAMURA Akira

Immunology

Professor(Additional Post)

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Assistant Professor

TAKEDA Kazuya

Immunology, Neuropathology

Assistant Professor

MATSUBA Shintaro

Immunological pharmacology

Assistant Professor

YABE-WADA Toshiki Immunology, Functional biochemistry, Structural biochemistry

Keywords of Researchallergy, autoimmune disease, immunoglobulin-like receptor,

Outline of Research
The focus of our work is to investigate the regulatory functions of immunoglobulin-like receptors, including Fc receptors(FcRs), paired immunoglobulin-like receptors (PIRs), and other immunoreceptors. In particular, we research the relationshipbetween immunoreceptors and diseases by using animal models for human diseases.

16

0210

Department of Medical Zoology

Title

Name

Field of Specialization

Senior Assistant Professor

OIKAWA Yosaburo

diagnosis of parasitic disease, tick-borne disease

Senior Assistant Professor

MURAKAMI Manabu

Infection-mediated arthropod

Faculty

Keywords of Researchparasite, cysticercosis, tick born disease, immunodiagnosis, antigen purification, circulating antigen, excretory/secretory
products, IgE antibody, molecular biological diagnosis, cysteine proteinase, Acanthamoeba, atopic dermatitis, mite, Myobia
musculi, Leptotrombidium, Japanese encephalitis Virus, mosquito, Culex tritaeniorhynchus, Culex tritaeniorhynchus, Aedes
albopictus

Outline of Research
The main subjects of our department are as follows:
1.Development of immunological and molecular biological diagnosis of parasitic diseases.
2.Epidemiological research of tick-born diseases in the Noto Peninsula,Ishikawa Prefect.
3.Investigation of mosquito situation around the pigpen in Ishikawa prefecture, and JE virus distribution.

Books
0210A001

T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus
Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.

Publications
Originals
0210B001

Y.Oikawa:Control of proliferation of Acanthamoeba in a soft contact lens case demonstrated by a newly devised
culture method using a liquid medium, Journal of Kanazawa Medical University, 40:1;1-8, 2015.

Reviews
0210C001

Y.Oikawa, M.Murakami:Investigation and research relevant to some sanitary animals examined in our department,
Journal of Kanazawa Medical University, 40:2・3;64-68, 2015.

17

0220

Department of Pathology and Laboratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

NOJIMA Takayuki

Professor

MINATO Hiroshi

Senior Assistant Professor

KUROSE Nozomu

surgical pathology, molecular pathology

Assistant Professor

KOBAYASHI Erikosurgical pathology, molecular pathology

Assistant Professor

NAKADA Satoko

surgical pathology

Assistant Professor

SHIOYA Akihiro

Surgical pathology

surgical pathology, molecular pathology, basic science on bone andsoft tissue tumors
Surgical pathology, Pathological study of head and neck, lung,mediastinum, and pleura

Keywords of Researchpathology, surgical pathology, molecular pathology, ultrastructure, cytology, laboratory medicine, standardization of blood
gas analysis, pulmonary function test, pulmonary pathology, lung, mediastinum, and pleura, head and neck, salivary gland

Outline of Research
1. Severe patients with chronic obstructive pulmonary diseases (COPD) frequently show expiratory flow limitation (FL)during spontaneous breathing, which is a marker of severely deteriorated pulmonary function and determines the prognosisof this disease. I have developed a new technique to detect FL with a brief interruption of airflow during spontaneous
breathing and have been studying for increasing the accuracy of this method.
2. Accuracy assurance of blood gas analysis: The recent blood gas analyzers are small, portable, and do measurements on
bedside (POCY: Point of Care Testing). However, it is difficult to maintain the accuracy of blood gas analysis because of
the disposable electrodes in this type of equipments. I have been developing a method of accuracy assurance for theseequipments with newly developed standard materials for blood gas analysis.

Books
0220A001

T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus
Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.

Publications
Originals
0220B001

T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki:CD14+ follicular dendritic cells in lymphoid follicles may play a role in
the pathogenesis of IgG4-related disease, Biomedical Research, 36:2;143-153, 2015.

0220B002

S.Nakada, H.Minato, T.Terauchi, Y.Miwa, N.Kurose, M.Nakano, T.Nojima:Prevalence of liquid based cytology inthe Hokuriku district based on a questionnaire survey, The Journal of the Japanese Society of Clinical Cytology,
54:2;128-134, 2015.

0220B003

H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.

18

Reviews
0220C001

Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Tangential frozen section
analysis for the surgical margins in breast-conserving surgery, American Journal of Breast Cancer Research ,
2:1;9-20, 2015.

Case Reports
0220D001

H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai,
T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.

0220D002

S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto,T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.

0220D003

N.Ueda, T.Ohnishi, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, E.Kinoshita, N.Kurose:A case of primary liver
adenosquamous carcinoma with central necrosis, 29:5;905-912, 2015.

0220D004

R.Kato, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, H.Minato:A case of NUT midline carcinoma of the lung, Japanese
Journal of Lung Cancer, 55:7;1080-1085, 2015.

Presentations at Conference
International Conference (Presentations)
0220I001

M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for
distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.

0220I002

Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of
18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th
Annual Asian Oncology Summit, 12th Annual Conference of the OOTR and the Kyoto Breast Cancer Consensus
Conference 2016, 2015.

0220I003

H.Minato, A.Iwakoshi, M.Hasegawa, S.Ichihara, S.Moritani, T.Tsuzuki, Y.Yatabe:A tracheal tumor of a young girl,The 6th Korean-Japanese Conjoint Slide Conference of Pulmonary Pathology, Seoul, 2015.

19

0230

Department of Social and Environmental Medicine

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

HONDA Ryumon

Environmental health, Statistical analysis, Analytical chemistry

Associate Professor

ISHIZAKI Masao

Occupational Health, Job stress

Keywords of Researchoccupation, work-related disease, mental health, cardiovascular disease, non-specific pulmonary disease, musculoskeletal
disease, metabolic syndrome, hypertension, job stress, abscentism, alcohol consumption, cigarette consumption, shift work,
work time

Outline of Research
To clarify the health effects of social environmental factors-mainly occupational factors, and establish appropriate, policies
for health promotion

Publications
Originals
0230B001

Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association ofcigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.

0230B002

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

Presentations at Conference
International Conference (Presentations)
0230I001

SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.

0230I002

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido, Y.Naruse:
Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22nd International
Symposium on Shiftwork and Working Time, Elsinore, 2015.

0230I003

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

20

0240

Department of Epidemiology and Public HealthFaculty
Title

Name

Field of Specialization

Professor

NISHINO Yoshikazu

Epidemiology of cancer, preventive medicine

Professor(Additional Post)

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Associate Professor

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

Associate Professor

NISHIJO Muneko

Environmental epidemiology, Environmental health sciences,
Epidemiology of cadmium pollution

Assistant
Professor(Additional Post)NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Keywords of Research
epidemiology, public health, cancer, hypertension, diabetes mellitus, screening, shift work, nutrition, calcium, stress,smoking, insulin resistance, work-related disease, environmental pollution, cadmium, renal tubular dysfunction, intractabledisease, cardiovascular disease, stroke, hyperlipidemia, dietary habits, salt, magnesium, health promotion, alcohol, lipid
peroxide, community registry, silicosis, Itai-itai disease, congenital anomaly, medical decision making, dioxin

Outline of Research
Epidemiology and Prevension of Lifestyle-related Diseases
Environmental Epidemiology
Epidemiology of Occupation-related Diseases
Epidemiology of Congenital Anomalies
Epidemiology of Interactable Diseases
Clinical Epidemiology

Publications
Originals
0240B001

K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.

0240B002

PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure andthe neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.

0240B003(A.Takazakura), M.Sakurai, Y.Bando, H.Misu, Y.Takeshita, Y.Kita, A.Shimizu, T.Hayakawa, K.Kato, S.Kaneko,
T.Takamura:Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic
nephropathy, Journal of Diabetes Investigation, 6:3;346-353, 2015.

0240B004

SY.Nagasawa, T.Ohkubo, K.Masaki, E.Barinas-Mitchell, K.Miura, T.Seto, A.El-Saed, T.Kadowaki, BJ.Willcox,
D.Edmundowicz, A.Kadota, RW.Evans, S.Kadowaki, A.Fujiyoshi, T.Hisamatsu, MH.Bertolet, T.Okamura,
Y.Nakamura, LH.Kuller, H.Ueshima, A.Sekikawa; ERA-JUNP Study Group:Associations between inflammatory
markers and subclinical atherosclerosis in middle-aged white,Japanese-American and Japanese men: The ERAJUMP study, Journal of Atherosclerosis Thrombosis, 22:6;590-598, 2015.

21

0240B005

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido,
H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal
dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.

0240B006(K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice forrenal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.

0240B007

N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyltranspeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis andThrombosis, 22:10;1051-1060, 2015.

0240B008(M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan (EPOCHJAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-term risks ofsubtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts in Japan.,Hypertension, 65:3;517-524, 2015.

0240B009(T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima;
NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.

0240B010(HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo,
H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinateddibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.

0240B011

TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa,T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.

0240B012

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

0240B013(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular
dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.

0240B014(IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination forsurvival data, Biometrical Journal, 57:4;592-613, 2015.

0240B015(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause
mortality increased by environmental cadmium exposure in the Japanese general population in cadmium nonpolluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.

Reviews
0240C001(C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis ofprospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.

0240C002(K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.

22

Presentations at Conference
International Conference (Synposium)
0240H001

M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.

0240H002

M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in theCadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.

International Conference (Presentations)
0240I001

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

0240I002

SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.

0240I003

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido,
Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22ndInternational Symposium on Shiftwork and Working Time, Elsinore, 2015.

0240I004

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

0240I005(TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H.
Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian
Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.

0240I006

TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples ofmother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.

0240I007

M.Nishijo, TN.Nghi, PN.Thao, PT.Tai, AH.Tran, HV.Luong, H.Nishijo:Dioxin effects on groeth andneurodevelopment of infants and children in Vietnam., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vietnam, Hanoi, 2015.

23

0250

Department of Legal Medicine

Faculty
Title

Name

Field of Specialization

Associate Professor

WANG Lu elaine

Tumor pathology, Endocrine pathology, Forensic pathology

Assistant Professor

TAKEICHI Toshiaki

ER-stress, Drug Dependence

Keywords of Researchdrug abuse, methamphtcamine, brain damage, forensic autopsy, drowning, immunohistochemistry, protinase K,

Outline of ResearchMechanism of methamphetamine abuse
Immunohistochemical analysis of brain damage in foreusic autopy cases
Application of proteinase K for diatome detection in the diagnosis of drowning

24

0260

Department of Medical Education

Title

Name

Field of Specialization

Professor

HORI Ariyuki

Professor

YASUDA Yukio

Senior Assistant Professor

TAKAMURA Akiteru

Comunity-based Medical Education, Simulated education

Senior Assistant Professor

KURODA Naohiro

medical informatics, electronic medical record system, medical
educatin

Faculty

medical education, clinical neurology, clinical sleep medicine,neurophysiology, medical informatics, problem-based learning
undergraduate clinical teaching, graduate education of physicians,
medical education

Keywords of Research
medical informatics, electronic recording, evidence-based medicine, information technology, computer-aided PBL,

Outline of Research
Improving medical education including a new course of integrated problem-based learning, a medical interview training
course before medical practice, management of medical informatics, practical training course using simulators, developing
new assessment for students’ practice, and providing new educational environment using e-shyllabi.

Publications
Originals
0260B001

A.Takamura, K.Ie, Y.Takemura:Overcoming challenges in primary care education: a trial of a longitudinal
integrated clerkship in a rural community hospital setting in Japan., Education for Primary Care, 26:2;122-126,
2015.

Reviews
0260C001

A.Takamura:The present circumstance of primary care in Japan, Quality in Primary Care, 23:4;262-266, 2015.

0260C002

A.Takamura:Community-based medical edusation for undergraduates -Importance of introducing longitudinal
integrated clerkship, Consortium for Education of Generalist, 7:98-102, 2015.

25

Clinical Medicine

0300

Department of Cardiology

Faculty
Title

Name

Field of Specialization

Professor

KAJINAMI Koji

Atherosclerosis, lipid metabolism

Professor

KITAYAMA Michihiko Ischemic heart disease, Coronary intervention

Associate Professor

KAWAI Yasuyuki

Associate Professor

TSUCHIYA Taketsugu Ischemic heart disease, Coronary intervention

Associate Professor

AKAO Hironobu

Ischemic heart disease, Coronary intervention

Associate Professor

FUJIOKA Nakaba

Arrhythmia, Catheter ablation

Assistant Professor

MOTOYAMA Atsushi Ischemic heart disease, Coronary intervention

Assistant Professor

WAKASA Minoru

Heart failure

Assistant Professor

ISHIDA Ryoko

Ischemic heart disease, Coronary intervention

Assistant Professor

IWADARE Mizuho

Atherosclerosis, hypertension

Assistant Professor

SAITO Ryuhei

Ischemic heart disease, Coronary intervention

Assistant Professor

AOKI Hirofumi

Heart failure

Assistant Professor

TANABE Kan

Heart failure

Assistant Professor

FUJIBAYASHI
Kousuke

Arrhythmia, Catheter ablation

Assistant Professor

WATANABE Makoto

Ischemic heart disease, Coronary intervention

Assistant Professor

TAKEDA Kenji

Molecular Biology

Ischemic heart disease, Coronary intervention

Keywords of Researchheart failure, hypertension, myocardial infarction, myocarditis, autonomic nervous function, atherosclerosis, metabolic
syndrome, brain natriuretic peptide, angina pectoris, apoptosis, homocysteine, coronary calcification, valvular disease,autoantibody, myocardial biopsy, cardiac PET, coronary intervention, dilated cardiomyopathy, gene therapy, long QT,
myocardial viability, pacemaker, aortitis syndrome, arrhythmia, catheter ablation, renin-angiotensin system, IABP,
microvascular angina, gene polymorphism, circadian variation

Outline of Research
１ Exploring risk factors and determinants of responsiveness to treatment or prognosis in cardiovascular diseases
２ Development of new therapeutics using the gene expression modification or the stem cell research technique
３ Visualization and quantification of the biological signal in cardiovascular system

26

Publications
Originals
0300B001(O.Iida), M.Nakamura, Y.Yamauchi, M.Fukunaga, Y.Yokoi, H.Yokoi, Y.Soga, K.Zen, S.Kan, N.Suematsu, N.Inoue,
K.Suzuki, K.Hirano, Y.Shintani, Y.Miyashita, K.Urasawa, I.Kitano, T.Tsuchiya, K.Kawamoto, T.Yamaoka,
M.Uesugi, T.Shinke, Y.Oba, N.Ohura, M.Uematsu, M.Takahara, T.Hamasaki, A.Nanto, OLIVE Investigators:3year outcomes of the olive registry, a prospective multicenter study of patients with critical limb ischemia. A
prospective, multi-center, three-year follow-up study on endovascular treatment for infra-inguinal vessel inpatients with critical limb ischemia, JACC-Cardiovascular Interventions, 8:11;1493-1502, 2015.

0300B002

T.Tsuchiya, O.Iida, T.Shiraki, Y.Soga, K.Hirano, K.Suzuki, T.Yamaoka, Y.Miyashita, M.Kitayama,
K.Kajinami:Clinical characteristics of patients with Rutherford category IV, compared with V and VI, SAGE open
medicine, 3:2050312115597087, 2015.

Presentations at Conference
International Conference (Presentations)
0300I001

H.Akao, M.Watanabe, R.Saito, M.Wakasa, A.Motoyama, R.Ishida, T.Tsuchiya, Y.Kawai, M.Kitayama, K.Kajinami:
In Vivo Evidence of Matrix Metalloproteinases(MMPs)and Vascular Inflammation: Coronary Rotational Atherectomy
Study, ISA2015, Amsterdam, 2015.

0300I002

M.Wakasa, H.Aoki, K.Fujibayashi, Y.Kawai, K.Kajinami:Association of plasma taurine levels with left ventricularfunction in patients with idiopathic dilated cardiomyopathy, HEART FAILURE 2015, Sevilla, 2015.

0300I003

K.Kajinami, K.Yamamoto, M.Sasagawa, A.Nakagawa:Homocystein-lowering effects of VCRESC?(a vitaminmicronutrient beverage)in patients with coronary artery disease, ISA2015, Amsterdam, 2015.

0300I004

K.Fujibayashi, Y.Kawai, W.Fujita, S.Takano, T.Takamura, M.Watanabe, K.Tanabe, M.Wakasa, M.Kitayama,
K.Kajinami:Increased level of circulating glutamate and cystine in patients with coronary vasospastic angina, ESC
CONGRESS 2015, London, 2015.

27

0310

Department of Respiratory Medicine

Faculty
Title

Name

Field of Specialization

Professor

TOGA Hirohisa

clinical respiratory medicine, sleep disordered breathing

Professor

OSANAI Kazuhiro

lung cell and molecular biology, COPD

Professor

ISHIZAKI Takeshi

Associate Professor

MIZUNO Shirolung cell and molecular biology，COPD

Associate Professor(Additional Post)

IGUCHI Masaharu

Respiratory Medicine

Senior Assistant Professor

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

Senior Assistant Professor

OIKAWA Taku

clinical respiratory medicine, lung cancer

Senior Assistant Professor

NAKAGAWA Kenclinical respiratory medicine, lung cancer

Assistant Professor

FUJIMOTO Yuki

clinical respiratory medicine

Assistant Professor

KOJIMA Koji

clinical respiratory medicine

Assistant Professor

SAITO Masatoshi

clinical respiratory medicine, sleep，sleep disordered breathing

Assistant Professor

TAKAHARA Yutaka

clinical respiratory medicine

Assistant Professor

KOBAYASHI Makoto lung cell and molecular biology

Assistant Professor

KAMEDA Mari

Assistant Professor

SHINOMIYA Shohei

clinical respiratory medicine

Keywords of Research
acute lung injury, cytokine, nitoric oxide, pulmonary alveolar type II cell, sleep apnea syndrome, acoustic reflection
technique, lung cancer, apoptosis

Outline of Research
1. Pathogenesis and therapy of acute lung injury
2. Cell biology of pulmonary alveolar epithelium
3. Pathogenesis and therapy of sleep-disordered breathing
4. Cell biology of lung cancer cells

Publications
Originals
0310B001

M.Wang, T.Shibamoto, S.Shinomiya, Y.Yamamoto, Y.Kurata, Y.Kuda, M.Tanida, H.Toga:Pulmonary vascular andairway responses to systemic vasoconstrictors in anesthetized BALB/c mice. , Journal of cardiovascularpharmacology, 65:4;325-334, 2015.

0310B002(J.Gomez-Arroyo), M.Sakagami, AA.Syed, L.Farkas, BV.Tassell, D.Kraskauskas, S.Mizuno, A.Abbate,
HJ.Bogaard, PR.Byron, NF.Voelkel:Iloprost reverses established fibrosis in experimental right ventricular failure,
European Respiratory Journal, 45:2;449-462, 2015.

28

0310B003

S.Mizuno, T.Ishizaki, H.Toga, A.Sakai, J.Isakova, E.Taalaibekova, Z.Baiserkeev, B.Kojonazarov, A.Aldashev:
Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks, Biomed Research International,
2015:1-6, 2015.

0310B004

T.Ishizaki, S.Mizuno, A.Sakai, S.Matsukawa, B.Kojonazarov, B.Zamirbek, Y.Umeda, M.Morikawa, M.Anzai,
T.Ishizuka, A.Aldashev:Blunted Activation of Rho-Kinase in Yak Pulmonary Circulation, Biomed ResearchInternational, 2015:1-5, 2015.

0310B005(S.Cheng), H.Chen, A.Wang, M.Xie, J.Xie, K.Osanai, J.Zhao, Y.Xu, W.Xiong, M.Zhou:Lentiviral vector-mediateddelivery of lysophatidylcholine acyltransferase 1 attenuates airway inflammation in ovalbumin-induced allergic
asthmatic mice, Asian Pacific Journal of Allergy and Immunology, 33:4;320-329, 2015.

Reviews
0310C001

S.Mizuno, HJ.Bogaard, T.Ishizaki, H.Toga:Role of p53 in lung tissue remodeling, World Journal of Respirology,
5:1;40-46, 2015.

Case Reports
0310D001

T.Oikawa, R.Kato, S.Kitadate, S.Shinomiya, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, S.Mizuno,
K.Osanai, H.Toga:ABPA-like Clinical Condition Associated with Bronchial Stenosis After Lung Lobectomy, The
Journal of the Japan Society for Rsepiratory Endoscopy, 37:2;203-208, 2015.

0310D002

Y.Takahara, K.Nakase, M.Nojiri, R.Kato, S.Shinomiya, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa,S.Mizuno, K.Osanai, H.Toga:A Case of Pulmonary Langerhans Cell Histiocytosis Diagnosed by a Cell Block from
Bronchoalveolar Lavage Fluid, The Journal of the Japan Society for Respiratory Endoscopy, 37:2;240-244, 2015.

0310D003

R.Kato, T.Oikawa, S.Mizuno, K.Osanai, H.Toga, H.Minato:A case of NUT midline carcinoma of the lung, Japanese
Journal of Lung Cancer, 55:7;1080-1085, 2015.

Presentations at Conference
International Conference (Presentations)
0310I001

S.Shinomiya, M.Nojiri, K.Nakase, R.Kato, Y.Takahara, M.Saito, K.Kojima, Y.Fujimoto, K.Nakagawa, T.Oikawa,S.Mizuno, K.Osanai, T.Shibamoto, H.Toga:Nitric oxide and β2-adrenoceptor activation attenuate pulmonary
vasoconstriction during anaphylactic hypotension in anesthetized BALB/c mice, Pulmonary vascular research
institute, China, 2015.

0310I002

S.Mizuno, R.Kato, M.Kobayashi, K.Nakagawa, T.Oikawa, K.Osanai, T.Ishizaki, H.Toga:Circulating vascularendothelial cell gene expressions in chronic obstructive pulmonary disease, ATS 2015 International Conference,
Denver, 2015.

0310I003

K.Osanai, M.Zhou, M.Nojiri, K.Nakase, R.Kato, M.Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno,
H.Toga:Exogenous expression of lysophosphatidylcholine acyltransferase 1 attenuates alveolar type II cell
apoptosis in oleic acid-induced acute lung injury in rats, ATS 2015 International Conference, Denver, 2015.

0310I004

K.Osanai, M.Zhou, M.Nojiri, K.Nakase, R.Kato, M,Kobayashi, T.Oikawa, K.Nakagawa, S.Mizuno,
H.Toga:Exogenous expression of lysophosphatidylcholine acyltransferase 1 attenuates alveolar type II cell
apoptosis in oleic acid-induced acute lung injury in rats, ATS 2015 International Conference, Denver, 2015.

29

0320

Department of Gastroenterology

Title

Name

Field of Specialization

Professor

ARISAWA Tomiyasu

Gastro-intestinal disorders

Associate Professor(Additional Post)SHIMASAKI Takeo

Molecular Oncology, Pancreatic cancer , tissue engineering．

Senior Assistant Professor

NAKAMURA
Masakatsu

Endoscopic thcrapy of early gastric cancer

Senior Assistant Professor

OTSUKA Toshimi

Clinico-pathological study of nonalcoholic steatohepatitis

Assistant Professor

HAYASHI Ranji

Inflammatory Bowel Disease

Assistant Professor

NOMURA Tomoe

Gastro-intestinal disorders

Faculty

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insuline resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therapy, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Endoscopic treatment for early cancer of the esophagus, stomach and colon③Hepatic support system for severe alcoholic hepatitis④Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver④Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0320B001

N.Kawada, H.Uehara, T.Hosoki, M.Takami, H.Shiroeda, T.Arisawa, Y.Tomita:Usefulness of Dual-Phase F-18FDG PET/CT for Diagnosing Small Pancreatic Tumors, Pancreas, 44:4;655-659, 2015.

0320B002

M.Nakamura, T.Tahara, H.Shiroeda, K.Matsunaga, T.Otsuka, J.Yonemura, T.Shibata, T.Arisawa:The effect ofshort-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived
artificial ulcer: A randomized controlled trial, Hepato-Gastroenterology, 62:137;219-224, 2015.

0320B003(T.Tahara), T.Shibata, M.Okubo, T.Kawamura, K.Sumi, T.Ishizuka, M.Nakamura, M.Nagasaka, Y.Nakagawa,N.Ohmiya, T.Arisawa, I.Hirata:Telomere length in non-neoplastic colonic mucosa in ulcerative colitis (UC) and its
relationship to the severe clinical phenotypes, Clinical and Experimental Medicine, 15:3;327-332, 2015.

30

0320B004(T.Tahara), T.Shibata, T.Kawamura, M.Okubo, Y.Ichikawa, K.Sumi, M.Miyata, T.Ishizuka, M.Nakamura,
M.Nagasaka, Y.Nakagawa, N.Ohmiya, T.Arisawa, I.Hirata:Fusobacterium detected in colonic biopsy andclinicopathological features of ulcerative colitis in Japan, Digestive Diseases and Sciences, 60:1;205-210, 2015.

0320B005(T.Tahara), T.Arisawa:DNA methylation as a molecular biomarker in gastric cancer, Epigenomics, 7:3;475-486,
2015.

0320B006(T.Tahara), T.Shibata, M.Okubo, T.Ishizuka, T.Kawamura, H.Yamashita, M.Nakamura, Y.Nakagawa, M.Nagasaka,
T.Arisawa, N.Ohmiya, I.Hirata:Association between interleukin-1 beta and tumor necrosis factor-alphapolymorphisms and symptoms of dyspepsia, Molecular Medicine Reports, 11:5;3888-3893, 2015.

0320B007(T.Shibata), M.Nakamura, T.Omori, T.Tahara, Y.Ichikawa, M.Okubo, T.Ishizuka, Y.Nakagawa, M.Nagasaka,
M.Nakamura, T.Arisawa, I.Hirata:Association between individual response to food taste and gastroesophageal
symptoms, Journal of Digestive Diseases, 16:6;337-341, 2015.

0320B008

Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George:Serum osteopontin
predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, PLoS
One, 10:3;e0118744, 2015.

31

0330

Department of Nephrology

Faculty
Title

Name

Field of Specialization

Professor

Clinicopathological study of nephritic and nephrotic syndrome,
YOKOYAMA Hitoshi Clinical study of blood purification, Clinicopathological study of renaltransplantation

Professor(Additional Post)TOMOSUGI Naohisa

Proteomics in clinical nephrology

Senior Assistant Professor

YAMAYA Hideki

Clinical nephrology

Senior Assistant Professor

ADACHI Hiroki

Clinical nephrology

Assistant Professor

IMURA Junko

Clinical nephrology

Assistant Professor

CHIKAZAWA
Yoshihiro

Clinical nephrology

Assistant Professor

NAKAGAWA Masaru Clinical nephrology

Assistant Professor

HAYAMA Satoshi

Clinical nephrology

Assistant Professor

FUJIMOTO Keiji

Clinical nephrology

Assistant Professor

MATSUI Yuki

Clinical nephrology

Assistant Professor

HAYASHI Norifumi

Clinical nephrology

Assistant Professor

OKINO Kazuaki

Clinical nephrology

Assistant Professor

MUKAI Kiyotaka

Clinical nephrology

Assistant Professor

OKUSHI Yuki

Clinical nephrology

Keywords of Researchacquired renal cystic disease, CT scan, renal cell carcinoma, dialysis patient, cytogenetics, chromosome, PCR, karyotype,
metalloproteinase, mesangial cell, renal disease, hemodialysis, hematuria, proteinuria, ADPKD, renal transplantation,
hyperuricemia, nephrotic syndrome, hyperparathyroidism, bone disease, imaging, RCC, cystic disease, chronic renal failure,survival, IgA, glomerulonephritis, acute renal failure, vitamin D, CAPD

Outline of Research
We performed the clinicopathological studies of nephritic and nephrotic syndrome, especially in human lupus nephritis. We
confirmed the usefulness of ISN/RPS 2003 lupus nephritis classification in the long-term followed cohort analysis. We also
analyzed the genetic backgrounds of familial focal segmental glomerulosclerosis (FSGS), and studied the early remission
induction therapy of minimal change nephrotic syndrome and FSGS. In the fields of renal transplantation, we analyzed
primary non-functioning kidneys and patients with chronic allograft nephropathy. As concern to chronic kidney diseases(CKD), we revealed the CKD population in Ishikawa Prefecture based on the health check program of general population.
As the application of proteomics analyses, we studied the uremic toxins and iron metabolism, especially hepcidin, in chronic
renal failure of both human and animal models. We applied blood purification and proteomics techniques in some co-ordinal
works of various research fields.

32

Publications
Originals
0330B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.

0330B002(M.Kuroda), M.Shimizu, N.Inoue, I.Ikeno, H.Nakagawa, A.Yokoi, Y.Niida, M.Konishi, H.Kaneda, N.Igarashi,
J.Yamahana, H.Taneichi, H.Kanegane, M.Ito, S.Saito, K.Furuichi, T.Wada, M.Nakagawa, H.Yokoyama,
A.Yachie:Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced
hemolytic uremic syndrome, Neurochemistry International, 85-86:24-30, 2015.

0330B003(S.Kitajima), K.Furuichi, N.Sakai, A.Sagara, Y.Shinozaki, T.Toyama, Y.Iwata, M.Shimizu, H.Yokoyama, S.Kaneko,
T.Wada:Relapse and its remission in Japanese patients with idiopathic membranous nephropathy, Clinical andExperimental Nephrology, 19:2;278-283, 2015.

0330B004

Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association ofcigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.

0330B005(M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Serum albumin, but not glycatedalbumin was a potent factor affecting the performance of GFR equation based on serum creatinine, Clinical andExperimental Nephrology, 19:2;284-292, 2015.

0330B006(Y.Yonekura), S.Goto, H.Sugiyama, H.Kitamura, H.Yokoyama, S.Nishi:The influences of larger physicalconstitutions including obesity on the amount of urine protein excretion in primary glomerulonephritis: research of
the Japan Renal Biopsy Registry, Clinical and Experimental Nephrology, 19:3;359-370, 2015.

0330B007

H.Yokoyama, H.Sugiyama, i.Narita, T.Saito, K.Yamagata, S.Nishio, S.Fujimoto, N.Mori, Y.Yuzawa, S.Okuda,
S.Maruyama, H.Sato, Y.Ueda, H.Makino, S.Matsuo:Outcomes of primary nephrotic syndrome in elderly Japanese:
retrospective analysis of the Japan Renal Biopsy Registry (J-RBR), Clinical and Experimental Nephrology,
19:3;496-505, 2015.

0330B008(Muso, Eri);Mune, Masatoshi;Hirano, Tsutomu;Hattori, Motoshi;Kimura, Kenjiro;Watanabe, Tsuyoshi;Yokoyama,
Hitoshi;Sato, Hiroshi;Uchida, Shunya;Wada, Takashi;Shoji, Tetsuo;Yuzawa, Yukio;Takemura, Tsukasa;Sugiyama,
Satoshi;Nishizawa, Yoshiki;Ogahara, Satoru;Yorioka, Noriaki;Sakai, Soichi;Ogura, Yosuke;Yukawa, Susumu;Iino,
Yasuhiko;Imai, Enyu;Matsuo, Seiichi;Saito, Takao:Immediate therapeutic efficacy of low-density lipoprotein
apheresis for drug-resistant nephrotic syndrome: evidence from the short-term results from the POLARIS Study,
Clinical and Experimental Nephrology, 19:3;379-386, 2015.

0330B009

K.Fujimoto, J.Imura, H.Atsumi, Y.Matsui, H.Adachi, H.Okuyama, H.Yamaya, H.Yokoyama:Clinical significance ofserum and urinary soluble urokinase receptor (suPAR) in primary nephrotic syndrome and MPO-ANCA-associatedglomerulonephritis in Japanese, Clinical and Experimental Nephrology, 19:5;804-814, 2015.

0330B010(M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Effects of serum albumin andglycated albumin levels on performance of the Japanese GFR equation based on serum cystatin C, Clinical andExperimental Nephrology, 19:4;626-630, 2015.

0330B011(E. Muso), M.Mune, T.Hirano, M.Hattori, K.Kimura, T.Watanabe, H.Yokoyama, H.Sato, S.Uchida, T.Wada,
T.Shoji, T.Takemura, Y.Yuzawa, S.Ogahara, S.Sugiyama, Y.Iino, S.Sakai, Y.Ogura, S.Yukawa, Y.Nishizawa,
N.Yorioka, E.Imai, S.Matsuo, T.Saito:A prospective observational survey on the long-term effect of LDL apheresis
on drug-resistant nephrotic Syndrome, Nephron Extra, 5:2;58-66, 2015.

0330B012

Y.Matsui, Y.Sunatani, N.Hayashi, K.Okino, Y.Okushi, K.Mukai, H.Adachi, H.Yamaya, K.Iwabuchi,
H.Yokoyama:DNA double-strand breaks induced intractable glomerular fibrosis in renal allografts, Clinical andExperimental Nephrology, 20:3;479-488, 2015.

0330B013

N.Hayashi, S.Akiyama, H.Okuyama, Y.Matsui, H.Adachi, H.Yamaya, S.Maruyama, E.Imai, S.Matsuo,
H.Yokoyama:Clinicopathological characteristics of M-type phospholipase A2 receptor (PLA2R)-related
membranous nephropathy in Japanese, Clinical and Experimental Nephrology, 19:5;797-803, 2015.

33

0330B014

K.Fujimoto, J.Imura, H.Adachi, H.Yamaya, H.Yokoyama:Soluble urokinase receptor in primary focal segmental
glomerulosclerosis , Journal of Kanazawa Medical University, 40:2・3;47-53, 2015.

Reviews
0330C001

H.Yokoyama:Epidemiology of nephrotic syndrome in adult and elderly Japanese, 252:11;1139-1144, 2015.

Case Reports
0330D001

Y.Sakata, A.Kitayama, R.Yoshimura, K.Anzawa, T.Fujii, K.Fujimoto, H.Yokoyama, T.Mochizuki:Case of cutaneous
phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient, Journal of Dermatology,
42:3;263-266, 2015.

Presentations at Conference
International Conference (Presentations)
0330I001

Y.Matsui, Y.Sunatani, K.Iwabuchi, H.Yokoyama:DNA double strand breaks accelerated collagen type VI secretionof glomerular endothelial cells, ERA-EDTA Congress in Amsterdam The Netherlands, London, 2015.

0330I002

H.Adachi, Y.Matsui, N.Hayashi, K.Fujimoto,J.Imura, H.Yamaya, H.Yokoyama:Adiponectin fractions influences thedevelopment of cardiovascular disease in Japanese renal transplant recipients, The Annual of American Sociey ofNephrology, San Diego, 2015.

0330I003

Y.Matsui, N.Hayashi, J.Imura, K.Fujimoto, H.Adachi, H.Yamaya, H.Yokoyama:DNA double strand breaks induced
collagen type VI secretion of glomerular endothelial cells in renal allografts, The Annual of American Sociey ofNephrology, San Diego, 2015.

0330I004

K.Fujimoto, Y.Matsui, N.Hayashi, J.Imura, H.Adachi, H.Yamaya, H.Yokoyama:Urinary and serum soluble
urokinase receptor levels predicts the therapeutic response of nephrotic syndrome, The Annual of American Sociey
of Nephrology, San Diego, 2015.

0330I005(K.Hiromura), K.Kayakabe, H.Ikeuchi, H.Sugiyama, M.Nagata, H.Sato, H.Yokoyama, Y.Nojima:Clinical andHistological Features of Lupus Nephritis in Japan: An Analysis of the Japan Renal Biopsy Registry (J-RBR), The
Annual of American Sociey of Nephrology, San Diego, 2015.

0330I006(M.Horio), E.Imai, Y.Yasuda, T.Watanabe, H.Yokoyama, H.Makino, S.Matsuo:Effect of Glycemic Control on
Estimated Glomerular Filtration Rate by Cystatin C, The Annual of American Sociey of Nephrology, San Diego,
2015.

34

0340

Department of Diabetology and Endocrinology

Faculty
Title

Name

Field of Specialization

Professor

KOYA Daisuke

diabetes, hypertension, obesity, aging

Associate Professor

NAKAGAWA Atsushi diabetes, pituitary diseases

Associate Professor

NISHIZAWA Makoto

diabetes, insulin secretion, thyroid diseases

Associate Professor

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

Associate Professor

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Senior Assistant Professor

KONISHI Kazunori

diabetes, arteriosclerosis

Senior Assistant Professor

TSUDA Shinichi

diabetes, hypertension, arteriosclerosis

Assistant Professor

KANASAKI Megumi

diabetes, hypertension, obesity, preeclampsia

Keywords of Researchdiabetic nephropathy, diabetic retinopathy, diabetic neuropathy, obesity, aldosterone, adrenal zona glomerulosa,transmembrane signaling mechanism, angiotensin, protein kinase C, blood pressure, ambulatory blood pressure monitoring,
hypertension, autonomic dysfunction, microalbuminuria, insulin resistance, incretin, entero-insular axis, mitochondrial genemutation, renin, Type 2 diabetes, artificial pancreas, selective hypoaldosteronism, Basedows disease, thyroid tumor, chronic
thyroiditis, glucose metabolism, endothelial function, nitric oxide, hyperlipidemia, antihypertensive therapy

Outline of Research
We study the relationship between intracellular oxidative stress and an anti-aging substance SIRT1 under diabetic
conditions. SIRT1, an enzyme relating to the anti-aging effect of calorie restriction, was shown to inhibit oxidative stressinduced apoptosis of renal mesangial cells in vitro. At present, using diabetic animals, we investigate expressions of SIRT1
under various conditions of oxidative stress and prevention effects of over-expression of SIRT1 against diabetic
complications.
Our clinical researches of the relation between the diurnal pattern of blood pressure and cardiovascular events among
diabetics are highly evaluated because of the long-term prospective observation. Recently, we have also focused on themetabolic syndrome and blood pressure pattern to find out the participation of adiponectin.
We also study the abdominal vagal afferent signals sensing gut hormones, which are pivotal for postprandial glucose
homeostasis.

Publications
Originals
0340B001(M.Yasuda-Yamahara), S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya,
M.Haneda, S.Ugi, H.Maegawa, T.Uzu:Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via
enhancing energy expenditure, Biochemical and Biophysical Research Communications, 465:2;249-255, 2015.

0340B002

S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of
DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.

35

0340B003(S.Araki), M.Haneda, D.Koya, K.Kondo, S.Tanaka, H.Arima, S.Kume, J.Nakazawa, M.Chin-Kanasaki, S.Ugi,
H.Kawai, H.Arai, T.Uzu, H.Maegawa:Urinary potassium excretion and renal and cardiovascular complications inpatients with type 2 diabetes and normal renal function, Clinical journal of the American Society of Nephrology :CJASN., 10:12;2152-2158, 2015.

0340B004(S.Kato), S.Maruyama, H.Makino, J.Wada, D.Ogawa, T.Uzu, H.Araki, D.Koya, K.Kanasaki, Y.Oiso, M.Goto,
A.Nishiyama, H.Kobori, E.Imai, M.Ando, S.Matsuo:Anti-albuminuric effects of spironolactone in patients with type2 diabetic nephropathy: a multicenter, randomized clinical trial, Clinical and Experimental Nephrology, 19:6;10981106, 2015.

0340B005(Y.Tanaka), S.Kume, H.Araki, J.Nakazawa, M.Chin-Kanasaki, S.Araki, F.Nakagawa, D.Koya, M.Haneda,
H.Maegawa, T.Uzu:1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney
proximal tubular cell, Free Radical Biology & Medicine., 89:831-841, 2015.

Reviews
0340C001

T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.

0340C002(M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa,
M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide:A new classification ofdiabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Journal of Diabetes
Investigation, 6:2;242-246, 2015.

0340C003

N.Ueki, S.Takeda, D.Koya, K.Kanasaki:The relevance of the renin-angiotensin system in the development of drugs
to combat preeclampsia, International Journal of Endocrinology [Electronic Resource], 2015:572713;1-12, 2015.

0340C004

Kidney fibrosis and endothelial injury, The japanese journal of Nephrology, 57:7;1200-1205, 2015.

0340C005

K.Nitta, M.kanasaki, K.Kanasaki, D.koya:The role of angiotensin-converting enzyme inhibition to cimbat kidney
fibrosis, Journal of Kanazawa Medical University, 40:2・3;131-138, 2015.

0340C006

Diagnosis and management of diabetic nephropathy, Nihon Rinsyo, 73:12;2037-2043, 2015.

0340C007(S.Kume), D.Koya:Autophagy: A novel therapeutic target for diabetic nephropathy, Diabetes & Metabolism
Journal., 39:3;451-460, 2015.

Case Reports
0340D001

Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing
hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.

Short Communications
0340E001

D.Koya:Epidermal growth factor receptor signaling and the progression of diabetic nephropathy, Journal of
Diabetes Investigation, 6:5;519-521, 2015.

Presentations at Conference
International Conference (Synposium)
0340H001

D.Koya:S21 Diabetic complications The role of autophagy in diabetic nephropathy, The Korean Society for
Biochemistry and Molecular Biology International Conference 2015, Seoul, 2015.

0340H002

D.Koya:Symposium12 Diverse cell signaling in metabolic syndrome High fat diet-induced hepatosteatosis wasameliorated by the treatment with ketogeic amino acid, 2015 International Congress on Obesity and Metabolic
Syndrome in conjunction with the 43rd Annual Scientific Meeting of KSSO, Seoul, 2015.

36

International Conference (Presentations)
0340I001

K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling
responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, 2015.

37

0350

Department of Hematology and Immunology

Faculty
Title

Name

Field of Specialization

Professor

MASAKI Yasufumi

Hematology and Immunology, Transfusion Medicine

Professor

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Associate Professor

FUKUSHIMA
Toshihiro

Hematology and Immunology, Clinical Parmacology

Associate Professor

TANAKA Masao

Rheumatology, Immunology

Senior Assistant Professor

KAWANAMI Takafumi Hematology and Immunology

Senior Assistant Professor

FUJITA Yoshimasa

Rheumatology, Immunology

Senior Assistant Professor

OGISO Hideo

Hematology and Immunology

Assistant Professor

KAWANAMI Haruka

Hematology and Immunology

Assistant Professor

SAKAI Tomoyuki

Hematology and Immunology

Assistant Professor

NAKAJIMA Akio

Hematology and Immunology

Assistant Professor

NAKAMURA Takuji

Hematology and Immunology

Assistant Professor

MIKI Miyuki

Hematology and Immunology

Assistant Professor

UEDA Yoshibumi

Hematology and Immunology

Assistant Professor

FURUMOTO Hidehiro Hematology and Immunology

Assistant Professor

HASHIZUME Chieko

Hematology and Immunology

Keywords of Research
autoimmune disorder, Sjogren's syndrome, malignant lymphoma, bone marrow transplantation, monoclonal
lymphoproliferation, EB virus and tumorigenesis, stem cell, chemotherapy, leukemia cell line, apoptosis, chemokines, lipid
raft, signal transduction, fractalkine, adhesion molecule, rheumatoid arthritis, systemic lupus erythematosus,

Outline of Research
We practice the translational research to develop the new anti-cancer or immunosuppressive drugs through basic researchin the fields of Hematology and Immunology.
Studies of immunological abnormalities and pathophysiology of autoimmune diseases:
1 Effects of chemokines on vascular injury and Th1 response during chronic inflammation.
2 Function of microdomain (lipid rafts) on lymphocyte activation and its contribution in autoimmune diseases.
3 Analysis of immunological disorder in sphingomyelin knockout mice.
4 Discovery and functional analysis of the new auto-antigens in rheumatoid arthritis.
5 Detection of stem cells in salivary glands and its implication for regenerative medicine.
Studies of hematological malignancies and development of anti-cancer drugs:
1 Analysis of EB-virus proteins and their roles in lymphoproliferative disorders.
2 Molecular biological analysis of drug resistance.
3 Roles of sphingomyelin on apoptosis.
4 Roles of SMS on niche of leukemia stem cells.

38

Books
0350A001(J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling thespecific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions(Angel Catalá), 91-128, America, 2015.

0350A002(H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative
disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.

Publications
Originals
0350B001

T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura,
H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda:Prospective
clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku
Hematology Oncology Study Group, Medical Oncology, 32:232-238, 2015.

0350B002(H.Sawai), H.Ogiso, T.Okazaki:Differential changes in sphingolipids between TNF-induced necroptosis andapoptosis in U937 cells and necroptosis-resistant sublines, Leukemia Research, 39:964-970, 2015.

0350B003(T.Nakane), K.Tamura, M.Hino, T.Tamaki, I.Yoshida, T.Fukushima, Y.Tatsumi, Y.Nakagawa, K.Hatanaka,
T.Takahashi, N.Akiyama, M.Tanimoto, K.Ohyashiki, A.Urabe, T.Masaoka, A.Kanamaru, Japan Febrile Neutropenia
Study:Cefozopran, meropenem, or imipenem-cilastatin compared with cefepime as empirical therapy in febrileneutropenic adult patients: A multicenter prospective randomized trial, Journal of Infection and Chemotherapy,
21:1;16-22, 2015.

0350B004

T.Satoh-Nakamura, N.Kurose, T.Kawanami, T.Nakamura, H.Iwao-Kawanami, A.Nakajima, M.Miki, T.Sakai,
Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki:CD14+ follicular dendritic cells in lymphoid follicles may play a role in
the pathogenesis of IgG4-related disease, Biomedical Research, 36:2;143-153, 2015.

0350B005

M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acidsphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein innatural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.

0350B006

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

0350B007(H.Yazama), K.Kitatani, K.Fujiwara, M.Kato, M.Hashimoto-Nishimura, K.Kawamoto, K.Hasegawa, H.Kitano,
A.Beilawska, J.Bielawski, T.Okazaki:Dietary glucosylceramides suppress tumor growth in a mouse xenograft modelof head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide,International Journal Clinical Oncology, 20:3;438-446, 2015.

0350B008(A.Khosroshahi), Z.S.Wallace, J.L.Crowe, T.Akamizu, A.Azumi, M.N.Carruthers, S.T.Chari, E.Della-Torre,
L.Frulloni, H.Goto, P.A.Hart, T.Kamisawa, S.Kawa, M.Kawano, M.H.Kim, Y.Kodama, K.Kubota, M.M.Lerch,
M.Löhr, Y.Masaki, S.Matsui, T.Mimori, S.Nakamura, T.Nakazawa, H.Ohara, K.Okazaki, T.H.Ryu, T.Saeki,
N.Schleinitz, A.Shimatsu, T.Shimosegawa, H.Takahashi, M.Takahira, A.Tanaka, M.Topazian, H.Umehara,
G.J.Webster, T.E.Witzing, M.Yamamoto, W.Zhang, T.Chiba, J.H.Stone:International consensus guidancestatedment on the management and treatment of IgG4-related disease, Arthritis & Rheumatology, 67:7;1688-1699,
2015.

0350B009

H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains,
Journal of Lipid Research, 56:8;1594-1605, 2015.

39

Reviews
0350C001(K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematologicalmalignancies, Molecules and Cells, 38:6;482-495, 2015.

0350C002

Y.Masaki, H.Shimizu, T.Nakamura(Satoh), T.Nakamura, A.Nakajima, H.Kawanami(Iwao), T.Kawanami, K.Yamada,
Y.Hamaguchi, M.Kawano, Y.Fujita, T.Fukushima:Diagnosis and treatment of IgG4-related disease-Including IgG4related skin disease-, Journal of Environmental Dermatology and Cutaneous Allergology, 9:4;212-217, 2015.

Case Reports
0350D001

H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai,
T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.

0350D002(H.Yohida), N.Yasuda, T.Hayashi, K.Tujii, M.Wato, S.Gamoh, K.Shimizutani, A.Tanaka, Y.Masaki, S.Morita:A
case of probable IgG4-related disease involving the unilateral trigeminal nerve of the cheek region, Oral Radiology,
31:193-198, 2015.

Others
0350F001(T.Narita), A.Inagaki, T.Kobayashi, Y.Kuroda, T.Fukushima, M.Nezu, S.Fuchida, H.Sakai, N.Sekiguchi, I.Sugiura,
Y.Maeda, H.Takamatsu, N.Tsukamoto, D.Maruyama, Y.Kubota, M.Kojima, K.Sunami, T.Ono, M.Ri, K.Tobinai,
S.Iida:t(14;16)-positive multiple myeloma shows negativity for CD56 expression and unfavorable outcome even in
the era of novel drugs, Blood Cancer Journal, 5:e285, 2015.

Presentations at Conference
International Conference (Key Note Lecture)
0350G001

T.Okazaki:Role of membrane lipids, sphingomyelin and ceramide in tumor cell growthi, migration and death.,
Cancer science institute of singapore, Singapore, 2015.

International Conference (Presentations)
0350I001

T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration ofmalignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.

0350I002(K.Miura),J. Konishi, T.Miyake, M.Masanori, A.Hojo, Y.Masaki, M.Uno, J.Ozaki, C.Yoshida, D.Niiya, K.Kitazume,
Y.Maeda, J.Takizawa, R.Sakai, Y.Nawa, T.Yano, K.Yamamoto, K.Sunami, Y.Hiramatsu, K.Aoyama, H.Tsujimura,
T.Hatta, M.Kanno:2680 a new prognostic model for elderly patients with diffuse large B-cell lymphoma treated with
R-CHOP, 57th Annual Meeting & Exposition, Orlando, 2015.

40

0360

Department of Neurology

Faculty
Title

Name

Field of Specialization

Professor

MATSUI Makoto

Clinical neurology, Neuroimmunology, Clinical Immunology

Professor(Additional Post)

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

TOMIOKA Ryo

Clinical neurology, Neuroimmunology

Associate Professor

NAGAYAMA Shigemi Clinical neurology, Neuroimmunology

Senior Assistant Professor

SANADA Mitsuru

Clinical neurology, Neurophysiology

Assistant Professor

FUJITA Michiyo

Clinical neurology

Assistant Professor

NAKANISHI Megumi

Clinical neurology, Neuroimmunology

Keywords of Researchclinical neurophysiology, epilepsy, apoptosis, cerebrovascular diseases, neuropathies, molecular genetics, ischemic strokes,
autoantibody, neuroimmunology, neuroinfection, experimental autoimmune encephalomyelitis,

Outline of Research
Development of new therapeutic strategies for the neuroimmunological disorders, including multiple sclerosis, by clarifying
their etiologies that may be elucidated from meticulous clinical and experimental approaches using experimental animalmodels, which have been established due to recent advances in basic immunology.

Publications
Originals
0360B001(N.Tachibana), M.Kinoshita, F.Kametani, K.Tanaka, Y.Une, Y.Komatsu, Y.Kobayashi, S.Ikeda:Expression of Nmethyl-D-aspartate receptor subunits in the bovine ovum: Ova as a potential source of autoantigens causing antiNMDAR encephalitis., The Tohoku Journal of Experimental Medicine, 235:3;223-231, 2015.

0360B002(R.Matsuda), T.Kezuka, A.Umazume, Y.Okunuki, H.Goto, K.Tanaka:Clinical profile of anti-myeli oligodendrocyte
glycoprotein antibody seropositive cases of optic neuritis., Neuro-Ophthalmology, 39:5;213-219, 2015.

0360B003(H.Nakajima), M.Motomura, K.Tanaka, A.Fujikawa, R.Nakata, Y.Maeda, T.Shima, A.Mukaino, S.Yoshimura,
T.Miyazaki, H.Shiraishi, A.Kawakami, A.Tsujino:Antibodies to myelin oligodendrocyte glycoprotein in idiopathic
optic neuritis, BMJ Open, 5:4;1-4, 2015.

0360B004(RS.Tsuburaya), N.Miki, K.Tanaka, T.Kageyama, K.Irahara, S.Mukaida, K.Shiraishi, M.Tanaka:Anti-myelin
oligodendrocyte glycoprotein (MOG) antibodies in a Japanese boy with recurrent optic neuritis, Brain &Development, 37:1;145-148, 2015.

0360B005

Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to
cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.

41

Reviews
0360C001

K.Tanaka:Recent update on autoimmune encephalitis/encephalopathy, Clinical and Experimental
Neuroimmunology, 6:70-82, 2015.

Case Reports
0360D001(R.Matsumoto), N.Mikuni, K.Tanaka, K.Usami, K.Fukao, T.Kunieda, Y.Takahashi, S.Miyamoto, H.Fukuyama,
R.Takahashi, A.Ikeda:Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody,
Epileptic Disorders, 17:1;89-94, 2015.

0360D002(H.Yaguchi), K.Tsuzaka, S.Shirai, M.Niino, T.Takahashi, K.Tanaka, I.Yabe, H.Sasaki:Importance of T1-MRI
enhanced pyramidal tracts in differential diagnosis as to paraneoplastic encephalomyelitis, Clinical Neurology and
Neurosurgery, 132:9-11, 2015.

0360D003(R.Miyamoto), H.Sumikura, T.Takeuchi, M.Sanada, K.Fujita, T.Kawarai, H.Mure, R.Morigaki, S.Goto,
S.Murayama, Y.Izumi, R.Kaji:Autopsy case of severe generalized dystonia and static ataxia with marked cerebellar
atrophy, Neurology, 85:1522-1524, 2015.

Short Communications
0360E001

K.Tanaka:Debate on the pathogenesis of paraneoplastic cerebellar degeneration with anti-Yo antibody:T-cellmediated or antibody mediated?, Clinical and Experimental Neuroimmunology, 6:3;222-224, 2015.

0360E002(M.Tanaka), M.Kinoshita, K.Tanaka:Corticosteroid and tacrolimus treatment in neuromyelitis optica relateddisorders., Multiple Sclerosis Journal, 21:5;669, 2015.

0360E003（M.Tanaka）, M.Kinoshita, JF.Foley, K.Tanaka, J.Kira, WM.Carroll:Body weight-based natalizumab treatment in
adult patients with multiple sclerosis, Journal of neurology, 262:3;781-782, 2015.

0360E004(M.Tanaka), M.Kinoshita, K.Tanaka:Anti-John Cunningham virus index in Japanese patients with multiple sclerosis
and neuromyelitis optica-related disorder., Clinical and Experimental Neuroimmunology, 6:3;309-311, 2015.

0360E005

M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada,
M.Matsui:Intractable cough as Characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum
disorder., Multiple Sclerosis Journal, 22:4;576-577, 2015.

Others0360F001

K.Tanaka:Pathogenesis of autoantibodies in autoimmune encephalopathies, Annual report of the Japan Epilepsy
Research Foundation, 26:83-90, 2015.

Presentations at Conference
International Conference (Synposium)
0360H001

K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.

International Conference (Presentations)
0360I001

K.Tsutsui, M.Fujita, T.Kanbayashi, M.Matsui, K.Tanaka.:Clinical features of anti-NMDAR antibody-positive
patients predominantly presenting with chronic psychosis and acute exacerbations., The Lancet Neurology
Autoimmune Disorders Conference, Balcerona, 2015.

42

0360I002

K.Tanaka, M.Fujita, K.Tsutsui, T.Kanbayashi, M.Matsui:Clinical Features of Anti-NMDAR Antibody-positive
Patients Predominantly Presenting Chronic Psychosis with Acute Exacerbations, 67th AAN Annual Meeting,Washington, 2015.

43

0363

Department of Medical Oncology

Title

Name

Field of Specialization

Professor

MOTOO Yoshiharu

Medical Oncology, Tumor Cell Biology, Gastroenterology

Professor

YASUMOTO Kazuo

Gastric cancer, Cancerous peritonitis molecular target therapy

Senior Assistant Professor

HISAMURA Kazuho

Social Work, Social Welfare, Psycho-Oncology

Faculty

Keywords of Research
medical oncology, clinical oncology, gastroenterology, chemotherapy, tumor biology,

Outline of Research
We are studying on pancreatic cancer, which is one of the most untreatable cancers. One of our projects is the research on
the cancerous expression of pancreatitis-associated proteins in human pancreatic cancer. We are cooperating with INSERM
in Marseille, France. The second project is the identification and characterization of new heat-shock proteins. The third
one is the elucidation of the molecular mechanisms of gemcitabine resistance of pancreatic cancer cells. We are cooperatingwith Cancer Research Institute of Kanazawa University, especially on glycogen synthase kinase. Other projects include themetabolome approach on the prediction of adverse reaction of anti-cancer drugs, and the proteome analysis on the
discovery of new molecular markers for pancreatic cancer.

Publications
Originals
0363B001(T.Suzuki), A.Yamamoto, M.Ohsawa, Y.Motoo, H.Mizukami, T.Makino:Ninjin'yoeito and ginseng extract prevent
oxaliplatin-induced neurodegeneration in PC12 cells, Journal of Natural Medicines, 69:4;531-537, 2015.

0363B002(K.Ohtsubo), H.Mouri, K.Yamashita, K.Yasumoto, D.Inoue, T.Gabata, H.Ikeda, H.Watanabe, S.Yano:Usefulness of
EUS-guided fine needle aspiration in diagnosis of autoimmune pancreatitis., ENDOSCOPIC FORUM for digestive
disease, 31:2;125-134, 2015.

0363B003

Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo,
K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.

Reviews
0363C001

Y.Motoo:Gender difference in clinical practice for cancer patients, Japanese Journal of Clinical Medicine,
73:4;666-670, 2015.

Case Reports
0363D001

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines offibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.

Others
0363F001

Y.Motoo:Description of Kampo medicines in the clinical practice guidelines for irritable bowel syndrome, Journal of
Gastroenterology, 50:7;816, 2015.

44

Presentations at Conference
International Conference (Synposium)
0363H001

Y.Motoo:Evidence Reports on Kampo Treatment (EKAT) and Kampo medicines in clinical practice guidelines(KCPG), The 10th International Congress of Complementary Medicine Research - ICCMR 2015, Jeju, 2015

0363H002

Y.Motoo,I.Arai,K.Tsutani:Systematic review on the use of Kampo diagnosis in randomized controlled trials of
Kampo medicines, 3rd International Symposium for Japanese Kampo Medicine (ISJKM), Vienna, 2015.

45

0366

Department of Infectious Diseases

Title

Name

Field of Specialization

Professor

IINUMA Yoshitsugu

Clinical Infectious Diseases, Infection Control and Prevention

Associate Professor

BABA Hisashi

Clinical Infectious Diseases, Infection Control and Prevention,
Clinical Microbiology

Assistant Professor

USUDA Daisuke

Clinical Infectious Diseases, Infection Control and Prevention

Faculty

Keywords of Research
Infectious diseases, Antimicrobial drug resistance, Immunocompromised host, Acid-fast bacilli, Antimicrobial drugs,

Outline of Research
1. Antimicrobial drug resistant bacilli infections
2. Infectious diseases in severe immunocompromised host
3. Acid-fast bacilli infections
4. Appropriate use of antimicrobial drugs

Publications
Originals
0366B001

Y.Tanaka, M.Matsumoto, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, Y.Iinuma:Causes of presence of ammonium
urate crystals in urinary sediments, The Japanese journal of medical technology, 64:2;179-185, 2015.

0366B002

K.Kanaya, N.Izumiya, O.Kobayashi, S.Komichi, Y.Sakagami, Y.Ysujita, T.Nakagawa, E.Nakano, C.Nakamuro,
A.Niikawa, S.Nishio, K.Masuoka, H.Baba, Y.Iinuma:Regional surveillance for the antimicrobial susceptibility ofanaerobic Gram-negative rods in the Hokuriku district of Japan, The Journal of the Japanese Society for ClinicalMicrobiology, 25:3;223-229, 2015.

0366B003(M.Yamamoto), S.Takakura, Y.Iinuma, G.Hotta, Y.Matsumura, A.Matsushima, M.Nagao, K.Ogawa, Y.Fujimoto,
A.Mori, Y.Ogura, T.Kaido, S.Uemoto, S.Ichiyama:Changes in surgical site infections after living donor livertransplantation, PLoS One, 10:8;e0136559, 2015.

Case Reports
0366D001

M.Matsumoto, Y.Tanaka, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, T.Fujiki, Y.Iinuma:Four pediatric cases ofammonium acid urate crystal with nephrotic syndrome, The Japanese journal of medical technology, 64:5;541-547,
2015.

46

0368

Department of General Internal Medicine

Faculty
Title

Name

Field of Specialization

Professor

KOBAYASHI Junji

Lifestyle-related disease, Diabetes, Laboratory medicine, General
medicine

Associate Professor

AKAZAWA Sumiyo

gender specific medicine, hypertension, molecular biology

Associate Professor

YAMAKAWA Jun-ichi General medicine, Kampo medicine

Associate Professor

UENISHI Hiroaki

Cardiovascular Medicine

Senior Assistant Professor

MORIYA Junji

General medicine, Kampo medicine

Senior AssistantProfessor(Additional Post)

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Assistant Professor

SAWADA Mio

Kanpo medicine, Women medical care

Keywords of Researchneurology, clinical epidemiology, alternative, clinical ethics, hospital management, general practise, obesity, infection

Outline of Research
The kampo medicine to the metabolic syndrome and chronic fatigue syndrome.

Publications
Originals
0368B001(H.Tada), M.Kawashiri, A.Nohara, A.Inazu, J.Kobayashi, H.Mabuchi, M.Yamagishi:Autosomal recessive
hypercholesterolemia: A mild phenotype of familial hypercholesterolemia: Insight from the kinetic study using stable
isotope and animal studies, Journal of Atherosclerosis and Thrombosis, 22:1;1-9, 2015.

0368B002(T.Shirakawa), K.Nakajima, S.Yatsuzuka, Y.Shimomura, J.Kobayashi, T.Machida, H.Sumino, M.Murakami:The roleof circulating lipoprotein lipase and adiponectin on the particle size of remnant lipoproteins in patients withdiabetes mellitus and metabolic syndrome, Clinica Chimica Acta, 440:123-132, 2015.

0368B003(H.Tada), MA.Kawashiri, M.Takata, K.Matunami, A.Imamura, M.Matuyama, H.Sawada, H.Nunoi, T.Konno,
K.Hayashi, A.Nohara, A.Inazu, J.Kobayashi, H.Mabuchi, M.Yamagishi:Infantile cases of sitosterolaemia with novel
mutations in the ABCG6 gene:Extreme hypercholesterolaemia is exacerbated by breastfeeding, JIMD Reports,
21:115-122, 2015.

0368B004(T.Shirakawa), K.Nakajima, Y.Shimomura, J.Kobayashi, S.Kimber, H.Peter, T.Machida, H.Sumino,
M.Murakami:Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceridelipase on remnant lipoprotein metabolism, Clinica Chimica Acta, 440:193-200, 2015.

0368B005

N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyltranspeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis andThrombosis, 22:10;1051-1060, 2015.

0368B006(H.Tada), M.Kawashiri, H.Okada, R.Teramoto, T.Konno, T.Yoshimuta, K.Sakata, A.Nohara, A.Inazu, J.Kobayashi,
H.Mabuchi, M.Yamagishi, K.Hayashi:Assessment of coronary atherosclerosis in patients with familial
hypercholesterolemia by coronary computed tomography angiography, American Journal of Cardiology, 115:6;724729, 2015.

47

0368B007

J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic
fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.

0368B008(H.Kakuda), J.Kobayashi, M.Kakuda, N.Takekoshi:Comparison of the long term effect of telmisartan/amlodipine
versus telmisartan/hydorochlorothiazide on day-by-day variability of home blood pressure in Japanese
hypertensive subjects, Journal of Kanazawa Medical University, 40:2-3;154-160, 2015.

Reviews
0368C001

J.Kobayashi, K.Miyashita, K.Nakajima, H.Mabuchi:Hepatic Lipase:A comprehensive view of it's role on plasma lipid
and lipoprotein metabolism, Journal of Atherosclerosis and Thrombosis, 22:10;1001-1011, 2015.

0368C002

J.Kobayashi, H.Mabuchi:Lipoprotein lipase and aherosclerosis, The Annals of Clinical Biochemistry, 52:6;632-637,
2015.

Case Reports
0368D001(M.Kawashiri), H.Tada, M.Hashimoto, M.Taniyama, T.Nakano, K.Nakajima, T.Inoue, M.Mori, C.Nakanishi,
T.Konno, K.Hayashi, A.Nohara, A.Inazu, J.Koizumi, H.Ishihara, J.Kobayashi, T.Hirano, H.Mabuchi,
M.Yamagishi:Extreme contrast of postprandial remnant-like particles formed in abetalipoproteinemia andhomozygous familial hypobetalipoproteinemia, JIMD Reports, 22:85-94, 2015.

0368D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines offibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.

Short Communications
0368E001(H.Kakuda), J.Kobayashi, M.Kakuda, J.Yamakawa, N.Takekoshi:The effect of anagliptin treatment on glucose
metabolism and lipid metabolism, and oxidative stress in fasting and postprandial states using a test meal in
Japanese men with type 2 diabetes, Endocrine, 48:3;1005-1009, 2015.

Others
0368F001

J.Kobayashi:How does bezafibrate affect the plasma LDL cholesterol levels?, Journal of Atherosclerosis andThrombosis, 22:7;658-659, 2015.

0368F002

J.Yamakawa, J.Moriya, J.Kobayashi:Research of the influence of female on the visceral fat by aging :The
improvement by a kampo medicine, Journal of Society for Women's Health Science Research , 4:1;45-48, 2015.

48

0370

Department of Geriatric Medicine

Title

Name

Field of Specialization

Professor

MORIMOTO Shigeto

Geriatrics, Hypertension, Calcium Metabolism, Dementia,
Osteoporosis

Professor(Additional Post)

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis

Professor(Additional Post)

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology, Cardiology

Associate Professor

OKURO Masashi

Geriatrics, Circulation, Hypertension, Atherosclerosis

Assistant Professor

IRITANI Osamu

Geriatrics, Circulation

Assistant Professor

MORITA Takuro

Geriatrics, Circulation

Assistant Professor

YANO Hiroshi

Geriatrics, Circulation

Assistant Professor

OKUNO Tazuo

Geriatrics, Circulation

Assistant Professor

HIMENO Taro

Geriatrics, Circulation

Faculty

Keywords of Researchelderly, cardiac function, pneumoia, frailty, stroke, hypertension, antihypertensive treatment, isolated systolic hypertension,
nutrition, dysphagia, diabetes mellitus, cardiac disease, atherosclerosis, dementia, depression, Hasegawa’s dementia scale,mini-mental state examination, eicosapentaenoic acid, osteoporosis,

Outline of Research
The main fields of research of our Department are to elucidate pathogeneses and to develop new treatments for acutediseases in the elderly including pneumonia, stroke, heart failure, and ischemic heart diseases, of hypertension, and ofelderly syndromes including dementia, falls/fractures, dysphagia, and bedridden. Besides these, we also research about
genetic backgrounds for many elderly diseases using analysis of SNIPs, and about pathogenesis of atherosclerosis using
culture of arterial cells.

Publications
Originals
0370B001(N.Kawai), N.Sakai, M.Okuro, S.Karakawa, Y.Tsuneyoshi, N.Kawasaki, T.Takeda, M.Bannai, S.Nishino:The sleeppromoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus,
Neuropsychopharmacology, 40:6;1405-1416, 2015.

0370B002

T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda,
S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.

49

0380

Department of Pediatrics

Faculty
Title

Name

Field of Specialization

Professor

SAIKAWA Yutaka

Pediatric hematology, Pediatric oncology

Associate Professor

NAKAMURA
Tsuneyuki

Pediatric cardiology

Senior Assistant Professor

ITO Masatsune

Senior Assistant Professor

SATO Hitoshi

Senior Assistant Professor

OKADA Naoki

Pediatric hematology, Pediatric oncology

Senior Assistant Professor

KOBAYASHI Azusa

Neonatology

Senior Assistant Professor

NAKAMURA Toshimi Pediatric allergy, Pediatric immunology

Senior Assistant Professor

FUJIKI Takuma

Pediatric Nephrology

Assistant Professor

AKITA Chisato

Pediatric cardiology

Assistant Professor

OGURI Masato

Pediatric cardiology.

Assistant Professor

KOH Giyo

Connective tissue disease

Assistant Professor

IKENO Kanjyu

Child neurology

Assistant Professor

KITTAKA Yuko

Pediatric allergy, Pediatric endocrinology

Pediatric endocrinology, Pediatric metabolism, Inborn errors of
metabolism
Infectionus disease in children, Moleculer biology, Child neurology,
Inborn errors of metabolism

Keywords of Research
DNA diagnosis, fatty acid oxidation, malignancy in childhood, peripheral blood stem cell, pituitary dwarfism, growth
disorders in children, Kawasaki's disease, Adriamycine-induced cardiomyopathy, methylmalonic acidemia, infant botulism,
leukemia in children, juvenile diabetes, congenital adrenal hyperplasa, congenital heart disease, arrhythmia in childhood,

Outline of Research
Clinical and basic research are actively going on at pediatric department in the area of Neonatology, Pediatric Infectious
Diseases, Pediatric Cardiology, Pediatric Allergy and Immunology, Pediatric Hematology and Oncology, Pediatric
Neurology, Psychosomatic Medicine, Pediatric Endocrinology, Inborn Errors of Metabolism.

Publications
Originals
0380B001(R.Takahiro), S.Nakamura, H.Kohno, N.Yoshimura, T.Nakamura, S.Ozawa, K.Hirono, F.Ichida,
M.Taguchi :Contribution of CYP3A isoforms to dealkylation of PDE6 inhibitors: A comparison between sildenafil
N-demethylation and tadalafil demethylenation, Biological & pharmaceutical bulletin, 38:1;58-65, 2015.

Case Reports
0380D001

M.Matsumoto, Y.Tanaka, C.Tanaka, S.Nakagawa, Y.Yanaida, K.Nagata, T.Fujiki, Y.Iinuma:Four pediatric cases ofammonium acid urate crystal with nephrotic syndrome, The Japanese journal of medical technology, 64:5;541-547,
2015.

50

Short Communications
0380E001(Y.Mitsui), T.Nakamura, K.Shimizu, N.Okamoto, S.Toki, Y.Kittaka, G.Ko, C.Akita, H.Sato, N.Okada,
A.Kobayashi, T.Nakamura, Y.Saikawa:Practical use of the electronic stethoscope for the pediatric residents'
training program, Journal of Kanazawa Medical University, 40:201-204, 2015.

Others0380F001

Y.Kittaka, N.Okamoto, S.Toki, G.Ko, M.Oguri, C.Akita, T.Nakamura, Y.Saikawa:Activation of the fibrinolytic
system during the initial stage in patients with Kawasaki disease, Progress in Medicine, 35:7;1112-1115, 2015.

Presentations at Conference
International Conference (Presentations)
0380I001

T.Nakamura, T.Nakamura, G.Ko, Y.Yamashita, C.Akita, Y.Saikawa:Over 5 Years Follow-up of Kawasaki Disease
with Atopic Bronchial Asthma, Eleventh International Kawasaki Disease Symposium, Honolulu, 2015.

0380I002(Y.Shimizu), T.Nakamura, G.Ko, M.Oguri, C.Akita, Y.Saikawa:Relationship between Kawasaki Disease relatedAngiopathy and Pressure Wave Reflection in the Arterial System, Eleventh International Kawasaki Disease
Symposium, Honolulu, 2015.

0380I003

T.Nakamura:Arterial dysfunction in pediatric patients with chronic illnesses, The 7th Joint Scientific Meeting
Between HUST-TMC and KMU, Wuhan, 2015.

51

0390

Department of Neuropsychiatry

Title

Name

Field of Specialization

Professor

KAWASAKI Yasuhiro

Cognitive neurosciences, Neuropsychology, Neuroimaging,
Psychopharmacology, Neurophysiology

Senior Assistant Professor

WATANABE Kenichiro Neuropsychology, Neuropharmacology

Senior Assistant Professor

UEHARA Takashi

Neuropharmacology

Senior Assistant Professor

KITAMOTO Fukumi

Psychotherapy, Clinical Psychology

Assistant Professor

KOSEKI Yojyu

Brain imaging

Assistant Professor

NITTA Yusuke

Consultation liaison psychiatry

Assistant Professor

HASHIMOTO Reiko

Psychotherapy, Clinical Psychology

Assistant Professor

KIHARA Hiroaki

Brain imaging,，Schizophrenia

Assistant Professor

SHIMADA Takamitsu Brain imaging,，Schizophrenia

Faculty

Keywords of Research
aged patients, age of onset, agramatism, amitriptyline, amnesic syndrome, amnesia, amnesies, amoxaplne, an interdict,anorexia nervose, anxiety, aphasic subtypes, apperceptive and associative forms, associated societies, astrocytoma,
attention deficit hyperactivity disorder(ADHD), acute reactive psychosis, aging

Outline of Research
1.Study on regional identification of brain language areas by functional MRI―application for surgical therapy of epilepsy
2.Study on action mechanisms of antipsychotic drugs by regional cerebral blood flow measurement using SPECT
3.Study on action mechanisms of antipsychotic drugs by neurotransmitter measurement using microdialysis in animal
experiments
4.Neuropsychological study on dementia or disturbance of high neuronal function such as aphasia
5.Clinical study on psychiatric disturbance in epilepsy
6.Study on cognitive-behavioural therapy for obsessive compulsive disorder
7.Study on music therapy for dementia

Publications
Reviews
0390C001

T.Uehara, T.Sumiyoshi, M.Kurachi:T-817MA, a novel neurotrophic agent, as a new pharmacotherapy ofschizophenia, Japanese Journal of Biological Psychiatry, 26:3;154-160, 2015.

0390C002

T.Uehara, T.Sumiyoshi, M.Kurachi:New pharmacotherapy targeting cognitive dysfunction of schizophrenia via
modulation of GABA neuronal function, Current Neuropharmacology, 13:6;793-801, 2015.

52

Presentations at Conference
International Conference (Presentations)
0390I001

Y.Nagayama, A.Fukutsuka, K.Ikuno, R.Kaneda, Y.Kawasaki, M.Kitamura, Y.Minabe, T.Nagasawa, H.Nakade,M.Oe:Relationship between coercive measures and nursing interventions in university hospital psychiatric wards inJapan, 17th Annual Conference of the International Society of Psychiatric-Mental Health Nurses, Seattle, 2015.

0390I002

Y.Matsuda, H.Kihara, K.Watanabe, R.Hashimoto, S.Takemoto, Y.Kawasaki:Support vector machine classification
for patients with major depressive disorder and bipolar disorder using near-inflated spectroscopy., 12th World
Congress of Biological Psychiatry, Athens, 2015.

53

0400

Department of Radiology

Faculty
Title

Name

Field of Specialization

Professor

TONAMI Hisao

Head and Neck Radiology, MRI Diagnosis

Professor

MATOBA Munetaka

Interventional Radiology, Diagnostic Imaging、Radiation therapy

Professor

WATANABE Naoto

Nuclear Medicine

Assistant Professor(Additional Post)OTA Kiyotaka

Radiation Therapy，Nuclear Medicine

Assistant Professor

KITADATE Masataka Interventional Radiology, Diagnostic Imaging

Assistant Professor

KONDO Tamaki

Assistant Professor(Additional Post)

TAKAHASHI Tomoko Nuclear Medicine, Diagnostic Imaging

Assistant Professor

TSUCHIYA Naoko

Diagnostic Imaging

Assistant Professor

DOAI Mariko

Diagnostic Imaging

Assistant Professor

TOYOTA Ichiro

Diagnostic Imaging

Assistant Professor

OISO Kazumasa

Diagnostic Imaging

Diagnostic Imaging

Keywords of Research
MRI, MRS, CT, US, IVR, radiotherapy, RI, PET, BAI, lung cancer, perfusion, diffusion, FDG, MTC, radiosurgery,brachitherapy, PEI, Sjogren, radiation, MRA, MRCP, color doppler, bone mineral, biopsy, RN, upper GI, TAE, meltalic
stent, contrast medium,

Outline of Research
1.Assessment of Tumor Microperfusion and Therapeutic Effect Influencing by Radiotherapy, Chemotherapy andTransarterial Embolization using MD-CT, MRI and MRS.
2.Assessment of Tumor Proliferative Potential and Malignant Grade using MRS, SPECT and PET.
3.Biological Study of Radiation Injury of Tumor and Normal Tissue after Stereotactic Radiosurgery by 3-D Radiotherapy
Planning System.
4.Study of Inhibiting Neointimal Proliferation after Angioplasty by 192Ir Intraarterial Irradiation.

Publications
Originals
0400B001

Y.Sasagawa, O.Tachibana, M.Doai, H.Tonami, H.Iizuka:Median nerve conduction studies and wrist magnetic
resonance imaging in acromegalic patients with carpal tunnel syndrome, Pituitary, 18:5;695-700, 2015.

0400B002

N.Watanabe:Our study of radiotoxicity after Iodine-131 Therapy for thyroid cancer, Journal of Kanazawa Medical
University, 40:182-185, 2015.

0400B003

M.Matoba, H.Tuji, Y.Shimode, T.Kondo, K.Oota, H.Tonami:Lesion regression rate based on RECIST: predictionof treatment outcome in patients with head and neck cancer treated with chemoradiotherapy compared with FDG
PET-CT, Journal of Radiation Research, 56:3;553-560, 2015.

54

0400B004

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions:comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015.

0400B005

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.

Case Reports
0400D001

H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai,
T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.

Presentations at Conference
International Conference (Presentations)
0400I001

M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for
distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.

0400I002

H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory
nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.

55

0410

Department of Cardiovascular Surgery

Faculty
Title

Name

Field of Specialization

Professor

AKITA Toshiaki

Cardiovascular surgery

Professor

KAWAHIRA Yoichi

Cardiovascular surgery

Professor

SHIKATA Hiroo

Vascular surgery

Associate Professor

MORIOKA Koichi

Cardiovascular surgery

Senior Assistant Professor

KOBATA Takashi

Vascular surgery

Senior Assistant Professor

NOGUCHI Yasuhisa

Vascular surgery

Senior Assistant Professor

MIZUNO Fumito

Cardiovascular surgery

Assistant Professor

TANAKA Hirokazu

Cardiovascular surgery, Vascular surgery

Assistant Professor

TSUCHIYA Hirokazu Cardiovascular surgery, Vascular surgery

Keywords of Research
Cardiac surgery, vascular surgery, respiratory surgery, pacemaker implantation, Arrhythmia surgery, ventricular assist
device, arteriosclerosis obliterans, thromboangitis obliterans, valvular surgery, coronary bypass surgery, surgery forcongestive heart failure, artificial vascular graft, endovascular stent grafting, respiratory surgery, lung cancer,

Outline of Research
1.Elucidation of different mechanism for ischemia-reperfusion injury of immature and mature heart; Development ofcardioplegia specific for neonate cardiac surgery.
2.Development of patient-specific cardiac supporting net for dilated heart failure patients
3.Endovascular stent-grafting for aortic aneurysm

Publications
Case Reports
0410D001

T.Kobata, H.Shikata, Y.Noguchi:Entry closure of stanford type B chronic aortic dissection using an elephant trunk
type stent graft, Japanese Journal of Endovascular Intervention , 16:1;27-30, 2015.

Presentations at Conference
International Conference (Presentations)
0410I001

T.Kobata:A case of TEVAR for false aneurysm in the remote period by the stent graftodevice, The 16th Congressof Asian society for Vascular Surgery, Bangkok, 2015.

56

0415

Department of Thoracic Surgery

Title

Name

Field of Specialization

Professor

SAGAWA Motoyasu

Professor

USUDA Katsuo

Associate Professor

MAEDA Sumikothoracsu surgery, lung cancer

Assistant Professor

TANAKA Makoto

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MACHIDA Yuichiro

thoracic surgery, lung cancer, pulmonary circulation

Assistant Professor

MOTONO Nozomu

thoracic surgery, lung cancer, pulmonary circulation

Facultythoracic surgery, lung cancer, video assisted thoracoscopic surgery,epidemiology of mass screening
thoracic surgery, video assisted thoracoscopic surgery, lung cancer,
mediastinal tumor, early lung cancer, interventional bronchology,
clinical cytology

Keywords of Researchthoracic surgery, lung cancer, mediastinal tumor, lung transplantation, video assisted thoracoscopic surgery, chemotherapy,
lung injury, alveolar epithelial cell, bronchoscopy, thoracoscopy, laser therapy, pneumothorax

Outline of Research
Lung tumor
1. Screening test for lung cancer
2. Virtual bronchoscopy
3. Ion channel on cancer cells
4. Chemotherapy
5. Surgical treatment
6. Video assisted thoracoscopic surgery (VATS)Mediastinal and pleural tumors
1. FDG-PET for mediastinal tumor
2. VATS
3. Surgical treatment and chemotherapy for malignant mesothelioma
Lung injury
1. Perioperative lung injury
2. Beta-agonist and antagonist therapy
3. Ischemia reperfusion lung injury
4. Aspiration lung injury
5. RAGE mice
New instruments
1. Bronchoscopy
2. Thoracoscopy

57

Publications
Originals
0415B001

M.Sagawa, T.Kobayashi, C.Uotani, Y.Kibe, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:A survey aboutfurther work-up for cases with positive sputum cytology during lung cancer mass screening in Ishikawa Prefecture,
Japan: a retrospective analysis about quality assurance of lung cancer screening, Japanese Journal of ClinicalOncology, 45:3;297-302, 2015.

0415B002(K.Ichikawa), T.Kobayashi, M.Sagawa, A.Katagiri, Y.Uno, R.Nishioka, J.Matsuyama:A phantom study investigating
the relationship between ground-glass opacity visibility and physical detectability index in low-dose chest
computed tomography, Journal of Applied Clinical Medical Physics, 16:4;202-215, 2015.

0415B003

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diffusion weighted imaging can distinguish benign from malignant mediastinal tumors and mass lesions:comparison with positron emission tomography, Asian Pacific Journal of Cancer Prevention, 16:6469-6475, 2015.

0415B004

K.Usuda, S.Maeda, N.Motono, M.Ueno, M.Tanaka, Y.Machida, M.Matoba, N.Watanabe, H.Tonami, Y.Ueda,
M.Sagawa:Diagnostic performance of diffusion-weighted imaging for multiple hilar and mediastinal lymph nodes with
FDG accumulation, Asian Pacific Journal of Cancer Prevention, 16:6401-6406, 2015.

Reviews
0415C001(H.Tanaka), T.Hiura, K.Nishii, M.Sato, K.Oketani, T.Kobayashi, H.Kobayashi, S.Takahashi, I.Sato, K.Eguchi,
T.Sobue, T.Nakayama, M.Sagawa:A randomized controlled trial on the efficacy of thoracic CT screening for lungcancer in non-smokers and smokers of<30 pack-years aged 50-64 years to provide the new evidence from japan,
The Journal of the Japanese Society of CT Screening, 22:2;3-8, 2015.

0415C002

M.Sagawa, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:Overdiagnosis in the CT screening for lungcancer, The Journal of the Japanese Society of CT Screening, 22:2;9-14, 2015.

0415C003

M.Sagawa, M.Tanaka, Y.Machida, N.Motono, S.Maeda, K.Usuda:Revision of the criteria for selecting subjects forsputumj cytology of lung cancer screening in Japan, Journal of Kanazawa Medical University, 40:2・3;44-46, 2015.

Case Reports
0415D001

H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai,
T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.

0415D002

Y.Machida, M.Tanaka, N.Motono, S.Maeda, K.Usuda, M.Sagawa:Successful treatment of bronchial fistula after
pulmonary lobectomy by endobronchial embolization using an endobronchial watanabe spigot, Hindawi Publishingcorporation , 425694:1-3, 2015.

0415D003

Y.Machida, M.Tanaka, N.Motono, S.Maeda, K.Usuda, M.Sagawa:Malignant fibrous histiocytoma accompanying
hemorrhage in the pleural cavity, Journal of Case Reports and Studies, 2:4;1-3, 2015.

0415D004

M.Sagawa, Y.Machida, M.Tanaka, N.Motono, S.Maeda, T.Sakuma, K.Usuda:Left pulmonary agenesis showing
extraordinary chest X-ray findings, American Journal of Respiratory and Critical Care Medicine, 191:9;1083, 2015.

Presentations at Conference
International Conference (Synposium)
0415H001

M.Sagawa:Identify the kevel of implementation and planning for CT screening camprehensive programs across theglobe: Japan, IASLC Strategic screening advisory committee(SSAC)CTScreening work shop, Denver, 2015.

0415H002

M.Sagawa, The JECS Study Group:Screening in Japan-The JECS Stedy, 15th world canference on lung cancer,
Denver, 2015.

58

0420

Department of General and Digestive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KOSAKA Takeo

Surgical treatment of gastric cancer

Professor

UEDA Nobuhiko

Surgical treatment of hepatobiliary and pancreatic disease

Professor

NOGUCHI Masakuni

Surgery of breast cancer

Associate Professor

OMOTE Kazuhiko

Surgical treatment of gastric cancer

Associate Professor

KINAMI Shinichi

Surgical treatment of gastric cancer

Associate Professor

NAKANO Yasuharu

Surgery of breast cancer

Senior Assistant Professor

FUJITA Hideto

Surgical treatment of gastric cancer,

Senior Assistant Professor

FUNAKI Hiroshi

Surgical treatment of gastric cancer

Senior Assistant Professor

NOGUCHI Miki

Surgery of breast cancer

Assistant Professor

ONISHI Toshio

Surgery of Digestive Diseases

Assistant Professor

ONO Yukako

Surgery of Digestive Diseases, Surgical treatment of breast cancer

Assistant Professor

KAIDA Daisuke

Surgery of Digestive Diseases

Assistant Professor

TOMITA Yasuto

Surgery of Digestive Diseases

Assistant Professor

MORIOKA Emi

Surgery of Digestive Diseases

Assistant Professor

FUJITA Jun

Surgery of Digestive Diseases

Keywords of Researchpancreato-biliary cancer, pattern of tumor invasion, laparoscopic surgery, safe and secure procedure, establishment of thelaparoscopic surgery, laparoscopic surgery for malignant disease, surgical procedure, generalization and standardization,functional preserving operation, education and training, engineering and robotics,

Outline of Research
1 Advanced surgery for gastrointrestinal cancer
2 Biomarker of gastrointestinal cancer
3 Gastrointestinal reconstruction and its evaluation
4 Function saving cancer surgery
5 Minimally invasive cancer treatment
6 Tailored cancer chemotherapy

Publications
Originals
0420B001(K.Nakada), M.Ikeda, M.Takahashi, S.Kinami, M.Yoshida, Y.Uenosono, Y.Kawashima, A.Oshio, Y.Suzukamo,
M.Terashima, Y.Kodera:Characteristics and clinical relevance of postgastrectomy syndrome assessment scale(PGSAS)-45: newly developed integrated questionnaires for assessment of living status and quality of life inpostgastrectomy patients, Gastric Cancer, 18:1;147-158, 2015.

59

0420B002(T.Namikawa), N.Hiki, S.Kinami, H.Okabe, T.Urushihara, H.Kawahira, N.Fukushima, Y.Kodera, T.Yumiba,
A.Oshio, K.Nakada:Factors that minimize postgastrectomy symptoms following pylorus-preserving gastrectomy:
assessment using a newly developed scale (PGSAS-45), Gastric Cancer, 18:397-406, 2015.

0420B003

T.Itoh, H.Kitakata, S.Kinami, K.Kawaura, K.Hamada, S.Azukisawa, R.Itoh, K.Omote, T.Kosaka, M.A.Fujino:New
treatment strategy for submucosa-infiltrating gastric cancer without sentinel node metastasis: A pilot study oflaparoscopy-assisted endoscopic full-thickness resection in an IN VIVO porcine model., ENDOSCOPIC FORUM
for digestive disease, 31:1;17-26, 2015.

0420B004

H.Funaki, Y.Fujii, J.Fujita, E.Morioka, D.Kaida, T.Ohnishi, Y.Tomita, M.Noguchi, H.Fujita, S.Kinami, Y.Nakano,N.Ueda, T.Kosaka:Clinical analysis of esophageal bypass surgery with nutritional assessment in patients withunresectable esophageal cancer, Japanese Journal of Cancer and Chemotherapy, 42:12;1543-1546, 2015.

0420B005(Y.Yoshida), K.Hirata, H.Matsuoka, S.Iwamoto, M.Kotaka, H.Fujita, N.Aisu, S.Hoshino, T.Kosaka, K.Maeda,
F.Kiyomi, Y.Yamashita:A single-arm phase Ⅱ validation study of preventing oxaliplatin-induced hyperseｎsitivity
reactions by dexamethasone: the AVOID trial, Drug Design, Development and Therapy, 9:6067-6073, 2015.

Reviews
0420C001

M.Noguchi, S.Miura, E.Morioka, Y.Ohno, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka:Is axillary reverse mapping
feasible in breast cancer patients?, European Journal of Surgical Oncology, 41:442-449, 2015.

0420C002(T.Fujimura), S.Fushida, T.Tsukada, J.Kinoshita, K.Oyama, T.Miyashita, H.Takamura, S.Kinami, T.Ohta:A newstage of sentiel node navigation surgery in early gastric cancer, Gastric Cancer, 18:210-217, 2015.

0420C003

Y.Ohno, M.Noguchi, M.Yokoi-Noguchi, Y.Nakano, T.Kosaka, N.Kurose, H.Minato:Tangential frozen section
analysis for the surgical margins in breast-conserving surgery, American Journal of Breast Cancer Research ,
2:1;9-20, 2015.

0420C004

S.Kinami, T.Kosaka:Is local resection of the stomach suitable as curative surgery for gastric cancer?, Journal of
Kanazawa Medical University, 40:2・3;145-148, 2015.

0420C005

M.Noguchi, Y.Nakano, M.Noguchi, Y.Ohno, E.Morioka, S.Miura:Oncoplastic breast conserving surgery: Volume
replacement replacement vs. volume displacement, Journal of Kanazawa Medical University, 40:2・3;37-43, 2015.

Case Reports
0420D001

T.Ohnishi, N.Ueda, D.Kaida, H.Fujita, S.Kinami, T.Kosaka:A case of xanthogranulomatous cholecystitis that wasable to observe an image change with time, 29:4;815-823, 2015.

0420D002

N.Ueda, S.Miura, E.Morioka, D.Kaida, Y.Tomita, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, H.Fujita, S.Kinami,
Y.Nakano, T.Kosaka:A case of gastric and pancreatic cancer resected with curative intent while preserving organfunction , Japanese Journal of Cancer and Chemotherapy, 42:12;2343-2345, 2015.

0420D003

Y.Tomita, Y.Fujii, S.Miura, J.Fujita, E.Morioka, D.Kaida, T.Ohnishi, Y.Ohno, M.Noguchi, H.Funaki, H.Fujita,
S.Kinami, Y.Nakano, N.Ueda, T.Kosaka, N.Sakata:A successful case of treatment of colonic metastsis andperitoneal recurrence of type 4 gastric cancer by using colectomy and chemotherapy, Japanese Journal of Cancer
and Chemotherapy, 42:12;1591-1593, 2015.

0420D004

N.Ueda, T.Ohnishi, D.Kaida, H.Fujita, S.Kinami, T.Kosaka, E.Kinoshita, N.Kurose:A case of primary liver
adenosquamous carcinoma with central necrosis, 29:5;905-912, 2015.

Others
0420F001

M.Noguchi:Z-11 trial and rethinking axillary reverse mapping, Breast Cancer, 22:99-100, 2015.

60

Presentations at Conference
International Conference (Presentations)
0420I001

Y.Nakano, M.Noguchi, M.Yokoi-Noguchi, Y.Ohno, E.Morioka, T.Kosaka, T.Takahashi, H.Minato:The roles of
18F-FDG-PET/CT and US-guided FNAC in assessment of axillary nodal metastases in breast cancer patients, 8th
Annual Asian Oncology Summit, 12th Annual Conference of the OOTR and the Kyoto Breast Cancer Consensus
Conference 2016, Kyoto, 2015.

61

0430

Department of Orthopaedic Surgery

Faculty
Title

Name

Field of Specialization

Professor

MATSUMOTO Tadami Hip surgery

Professor

KAWAHARA Norio

Spinal surgery

Professor

KANEUJI Ayumi

Hip and Knee surgery, Sports medicine

Associate Professor

SUGIMORI Tanzo

Hip and Knee surgery, Sports medicine

Associate Professor

ICHISEKI Toru

Hip surgery, Shoulder surgery

Senior Assistant Professor

FUKUI Kiyokazu

Hip surgery

Senior Assistant Professor

HIROMURA Kentaro

TraumaSenior Assistant Professor

KAWAGUCHI
Masahito

Spinal surgery

Assistant Professor

HATANO Eijyu

Spinal surgery

Assistant Professor

TACHI Yoshiyuki

Spinal surgery

Assistant Professor

TAKAHASHI Eiji

Hip surgery

Assistant Professor

ORITA Yugo

Spinal surgery, orthopaedic surgery

Assistant Professor

TAGUCHI Keita

orthopaedic surgery

Assistant Professor

UEDA Shusuke

Hip surgery

Assistant Professor

SHIMIZU Yoshiaki

Spinal surgery

Assistant Professor

TSUDA Ryoji

Hip surgery

Keywords of Researchherniated nucleus pulposus, spondylosis, spondylolysis, spondylolisthesis, degenerative spondylolisthesis, giant cell tumor,
coxarthrosis, gonarthrosis, carpal tunnel syndrome, acromioclavicular dislocation, gonaarthritis purulenta, nerve graft,patellar tendon rupture, rheumatiod arthritis, benign chondroblastoma, patella subluxation syndrome, posterior lumbarinterbody fusion, osteotomy, lumbar disc decompression, hallux valgus, synovectomy, total hip arthroplasty, tendon suture,
humeral shaft fracture, osteonecrosis, spinal cord injury

Outline of Research
There are three types of proximal femur in Japanese hip osteoarthritis patients and we are developing a new femoral
prosthesis that would be more suitable for the Japanese patient using a computer aided design system. Additionally we areresearching some factors such an intravascular obstructive lesion or oxidative stress that would be cause for steroid induced
osteonecrosis of femoral head to prevent the occurrence of the disease.
Furthermore, regarding digestion of chondroitin sulfate proteoglycans(CSPG) that accumulate at injured site after spinal
cord injury, we confirmed that Hyaluronidase-4 expressed at injured spinal cord. It have been thought that Hyaluronidase-4
is a digestive enzyme of CSPG . In future, we will clarify the mechanism.

62

Publications
Originals
0430B001

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.

0430B002

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto, Y.Hiejima:Clinical assessment after total hip
arthroplasty using the Japanese Orthopaedic Association Hip-Disease Evaluation Questionnaire, Journal of
Orthopaedics, 12:sup.1;S31-S36, 2015.

0430B003

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto:Does rotational acetabular osteotomy affect subsequent
total hip arthroplasty?, Archives of Orthopaedic and Trauma Surgery, 135:3;407-415, 2015.

0430B004(Y.Okamoto), H.Murakami, S.Demura, S.Kato, K.Yoshioka, H.Hayashi, J.Sakamoto, N.Kawahara, H.Tsuchiya:The
effect of kyphotic deformity because of vertebral fracture - a finite element analysis of a 10 and 21 degree wedgeshaped vertebral fracture model -, The spine journal : official journal of the North American Spine Society,
15:4;713-720, 2015.

0430B005

K.Fukui, A.Kaneuji, T.Sugimori, T.Ichiseki, T.Matsumoto:Bone remodeling after a mean of 10 years in diaphyseal
cortical defects repaired with femoral revision using bypass fixation of extensively porous-coated stems with highstiffness, European Journal of Orthopaedic Surgery & Traumatology : OrthopéDie Traumatologie, 25:4;741-747,
2015.

0430B006

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:Rotational acetabular osteotomy forosteoarthritis with acetabular dysplasia: Conversion rate to total hip arthroplasty within twenty years andosteoarthritis progression after a minimum of twenty years, The Journal of bone and joint surgery. American
volume, 97:9;726-732, 2015.

0430B007(CL.Goldstein), PP.Varga, ZL.Gokaslan, S.Boriani, A.Luzzati, L.Rhines, CG.Fisher, D.Chou, RP.Williams,
MB.Dekutoski, NA.Quraishi, C.Bettegowda, N.Kawahara, MG.Fehlings:Spinal hemangiomas: results of surgicalmanagement for local recurrence and mortality in a multicenter study, Spine-Phila Pa 1976, 40:9;656-664, 2015.

0430B008(H.Hayashi), H.Murakami, S.Demura, S.Kato, N.Kawahara, H.Tsuchiya:Outcome of posterior lumbar interbody
fusion for L4-L5 degenerative spondylolisthesis, Indian journal of orthopaedics, 49:3;284-288, 2015.

0430B009

S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused
by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.

0430B010

S.Simizu:Inhibitory effect of hyaluronidase-4 in a rat spinal cord hemisection model, Journal of Kanazawa Medical
University, 40:1;9-16, 2015.

0430B011

T.Ichiseki, S.Ueda, Y.Ueda, A.Kaneuji, N.Kawahara, T.Matsumoto:Age-related changes of mitochondrialtranscription factor a expression in rotator cuff degeneration, American Journal of Translational Research,
7:10;2099-2104, 2015.

0430B012(D.Choi), Z.Fox, T.Albert, M.Arts, L.Balabaud, C.Bunger, JM.Buchowski, MH.Coppes, B.Depreitere,
MG.Fehlings, J.Harrop, N.Kawahara, JA.Martin-Benlloch, EM.Massicotte, C.Mazel, FC.Oner, W.Peul,
N.Quraishi, Y.Tokuhashi, K.Tomita, JJ.Verlaan, M.Wang, HA.Crockard:Prediction of quality of life and survival
after surgery for symptomatic spinal metastases: a multicenter cohort study to determine suitability for surgicaltreatment, Neurosurgery, 77:5;698-708, 2015.

Case Reports
0430D001

K.Fukui, A.Kaneuji, M.Fukushima, T.Matsumoto:Early MRI and intraoperative findings in rapidly destructive
osteoarthritis of the hip: a case report, International Journal of Surgery Case Reports, 8:13-17, 2015.

0430D002

T.Ichiseki, S.Ueda, T.Matsumoto:Rare coexistence of gouty and septic arthritis after arthroscopic rotator cuff
repair: a case report, International Journal of Clinical and Experimental Medicine, 8:3;4718-4720, 2015.

63

0430D003

K.Fukui, A.Kaneuji, T.Matsumoto:Occult fracture of the femoral neck associated with extensive osteonecrosis of
the femoral head: a case report, International Journal of Surgery Case Reports, 14:136-140, 2015.

0430D004(K.Yoshioka), H.Murakami, S.Demura, S.Kato, N.Kawahara, K.Tomita, H.Tsuchiya:Spinal metastasis fromsubcutaneous sacrococcygeal ependymoma: a case report with long-term follow up, The Surgery Journal, 1:1;e50e53, 2015.

Presentations at Conference
International Conference (Key Note Lecture)
0430G001

N.Kawahara: Spinal cord blood flow after ligation of multiple segmental arteries. Animal research and clinicalexperience, 4th Bologna-Budapest Spine: AOSpine symposium, Bologna, 2015.

0430G002

N.Kawahara: Infection after surgical treatment of spine tumor, 4th Bologna-Budapest Spine Meeting on Tumor &Osteoporosis, Bologna, 2015.

0430G003

N.Kawahara: Preoperative embolization of multiple segments for reduction of intraoperative bleeding in spinal
tumor surgery, 4th Bologna-Budapest Spine Meeting on Tumor & Osteoporosis, Bologna, 2015.

International Conference (Synposium)
0430H001

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:Cementless anatomic total hip femoral
component with circumferential porous coating for hips with developmental dysplasia: a minimum ten-years followup period, 2015 ICJR Hip JAPAN (International Congress for Joint Reconstruction), Osaka, 2015.

International Conference (Presentations)
0430I001

K.Fukui, A.Kaneuji, T.Matsumoto, K.Shintani:Squeaking and microcracks in a Delta-delta ceramic coupling: pinon-disc study, ORS 2015 Annual Meeting (Orthopaedic Research Society), Las Vegas, 2015.

0430I002

K.Fukui, K.Briggs, C.Trindade, M.Philippon:Patient-centered outcomes in borderline dysplastic patients withfemoroacetabular impingement who underwent labral repair and treatment of impingement, 10th Biennial Congressof International Society of Arthroscopy, Knee Surgery and Orthopaedic Sports Medicine (ISAKOS 2015), Lyon,
2015.

0430I003

A.Kaneuji, T.Sugimori, T.Ichiseki, K.Fukui, E.Takahashi, T.Matsumoto:A minimum ten-year result for cementless
acetabular components fixed without press-fit in developmental dysplasia of the hip, ICJR 2015 2nd Annual Pan
Pacific Orthopaedic Congress, Kona, 2015.

0430I004

E.Takahashi, A.Kaneuji, K.Hirosaki, M.Takano, R.Tsuda, T.Matsumoto:Relationship between bone cement
thickness and cement creep: an experimental study using collarless polished tapered stems, ICJR 2015 2nd Annual
Pan Pacific Orthopaedic Congress, Kona, 2015.

0430I005

K.Fukui, A.Kaneuji, T.Matsumoto:Arthroscopic correction for concomitant cam impingement in a patient with
idiopathic osteonecrosis of the femoral head, ISHA Annual Scientific Meeting 2015 (International Society for Hip
Arthroscopy), Cambridge, 2015.

0430I006

A.Kaneuji, E.Takahashi, R.Tsuda, T.Matsumoto, L.Kerboull:Biomechanical behavior of stem and cement in acollarless polished tapered stem and a french stem: an experimental study using original biomechanical instrument,
ISTA 2015 (International Society for Technology in Arthroplasty), Vienna, 2015.

0430I007

E.Takahashi, A.Kaneuji, K.Hirosaki, M.Takano, R.Tsuda, T.Matsumoto:Difference of stem subsidence and cement
behavior in the various thickness of bone cement: an experimental study using a collarless polished tapered stems,
ISTA 2015 (International Society for Technology in Arthroplasty), Vienna, 2015.

64

0440

Department of Neurosurgery

Faculty
Title

Name

Field of Specialization

Professor

IIZUKA Hideaki

spinal disease, brain tumor, peripheral nerve disease

Professor

TAKADA Hisashi

cerebrovascular disease，endovascular therapy

Professor

AKAI Takuya

brain tumor, pediatric neurosurgical disease

Senior Assistant Professor

SIRAGA Syunsuke

cerebrovascular disease

Assistant Professor

SASAGAWA Yasuo

brain tumor

Professor

TACHIBANA Osamu

brain tumor, hypothalamic and pituitary tumor

Senior Assistant Professor

OKAMOTO Kazuya

brain tumor, stereotactic radiosurgery

Assistant Professor

TSUKADA Tsuyoshi

general neurosurgery，neuroembryology

Assistant Professor

TORIGOE Keiichiro

general neurosurgery

Keywords of Researchbrain neoplasm, glioma, meningioma, neurinoma, skull base tumor, subarachnoid hemorrhage, cerebral aneurysm,
arteriovenous malformation, stroke, radiosurgery, endovascular therapy, microvascular decompression, skull base surgery,spinal surgery, spinal fusion, atlantoaxial dislocation, cervical spondylosis, ossification of the spinal ligament, syringomyelia,spinal dysraphism, spinal neoplasm, spinal injury, neural injury, experimental spinal injury, spinal cord compression, cerebral
ischemia

Outline of Research
The purpose of research is to regenerate the damaged neurological function by disclosing the pathogenesis of brain, spinal
cord and peripheral nerve diseases. The goal of research is to contribute to improve patient prognosis. For the purpose, theresearchers have to find out problems based on their clinical view points and solve those questions. The subjects of disease
are brain tumors, spinal diseases, cerebrovascular diseases, head injuries and congenital anomalies.
1. Brain tumor
1) development of tumor differentiation induction therapy for malignant gliomas
2) disclose the poor prognosis factors in malignant gliomas (by genetic sub classification and protein expression study)3) prediction of treatment results in the stereotactic radiosurgery against metastatic brain tumors ( by genetic classificationand protein expression study)4) radiological diagnosis of cystic pituitary tumors5) disclose the pathogenesis of secondary hypophysitis
2. Spine and spinal cord disease1) disclose the cord degeneration mechanism by spinal cord compression model2) long term treatment results and affecting factors in spinal surgery
3. Cerebrovascular disease1) disclose the molecular biological mechanism for acquisition of cerebral ischemia
4. Head injury1) operation methods and recurrence in chronic subdural hematoma
5. Congenital anomaly1) treatment of hydrocephalus in fetus model2) disclose the responsible gene and surgical treatment for craniosynostosis

65

Publications
Originals
0440B001

Y.Sasagawa, O.Tachibana, M.Doai, H.Tonami, H.Iizuka:Median nerve conduction studies and wrist magnetic
resonance imaging in acromegalic patients with carpal tunnel syndrome, Pituitary, 18:5;695-700, 2015.

0440B002

Y.Sasagawa, T.Akai, O.Tachibana, H.Iizuka:Diagnostic value of interleukin-10 in cerebrospinal fluid for diffuse
large B-cell lymphoma of the central nervous system, Journal of neuro-oncology, 121:1;177-183, 2015.

0440B003

T.Tsukada, E.Simamura, H.Shimada, T.Arai, N.Higashi, T.Akai T, H.Iizuka, T.Hatta:The suppression of maternalfetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in
mice, PLoS One, 10:6;e0129011, 2015.

0440B004

S.Shiraga, T.Akai, H.Takata, K.Okamoto, H.Iizuka:Investigation into the treatment outcome and problems of neckclipping and coil embolization for ruptured cerebral aneurysms, Japanese Journal of Stroke, 37:1;1-6, 2015.

0440B005

K.Okamoto:Fractionated stereotactic radiotherapy for residual nonfunctioning pituitary adenoma, Stereotactic
Radiotherapy, 19:9-14, 2015.

0440B006

M.Yamashita, T.Akai, M.Kishibe, K.Shimada:One-piece bone flap osteotomy using thread wire saw for frontoorbital advancement with distraction osteogenesis in craniosynostosis, Child's Nervous System, 31:2;279-283,
2015.

Reviews
0440C001

O.Tachibana:Rathke cleft cyst: review of pathology, imaging, and surgical outcome, Progress in Neuro-Oncology,
22:2;12-21, 2015.

Case Reports
0440D001

Y.Hayashi, M.Oishi, D.Kita, T.Watanabe, O.Tachibana, J.Hamada:Pure ｌymphocytic infundibuloneurohypophysitis
caused by the rupture of rathke's cleft cyst: Report of 3 cases and review of the literature, Turkish Neurosurgery,
25:2;332-336, 2015.

0440D002

Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing
hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.

0440D003

T.Akai, K.Torigoe, M.Fukushima, H.Iizuka, Y.Hayashi:De novo aneurysm formation following gamma knife surgery
for arteriovenous malformation: A case report, Journal of neurological surgery reports, 76:1; e105-e108, 2015.

0440D004

S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto,T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.

0440D005

S.Shiraga, T.Akai, H.Takata, H.Iizuka:Possible cerebral infarction due to multiple segmental cerebral vasospasms
after carotid artery stenting: A case report, No Shinkei Geka, 43:12;1081-1089, 2015.

Presentations at Conference
International Conference (Presentations)
0440I001

M.Doai, I.Toyota, H.Tonami, Y.Sasagawa, O.Tachibana, T.Nojima:Utility of apparent diffusion coefficient value for
distinguishing pituitary atypical adenomas from typical adenomas, European Congress of Radiology2015, Wien,
2015.

0440I002

T.Akai:Troubleshooting distraction osteogenesis for craniosynostosis, The 27th Annual Meeting of KSPN & 2015
JSPN-KSPN Joint Meeting, Soul, 2015.

66

0440I003

K.Okamoto, H.Iizuka, M.Futayama, K.Higashi:Clinical condition and frequency of delirium in head trauma patientsat neuro-intensive care unit, International Association of Risk Management in Medicine, Wien, 2015.

0440I004

T.Akai:One-piece bone flap osteotomy using thread wire saw for fronto-orbital advancement in craniosynostosis,
International society of craniofacial surgery, Chiba, 2015.

67

0450

Department of Plastic and Reconstructive Surgery

Faculty
Title

Name

Field of Specialization

Professor

KAWAKAMI Shigehiko Plastic and Reconstructive Surgery

Associate Professor

SHIMADA Kenichi

Plastic and Reconstructive Surgery

Senior Assistant Professor

YAMASHITA
Masanobu

Plastic and Reconstructive Surgery

Senior Assistant Professor

KISHIBE Miyuki

Plastic and Reconstructive Surgery

Assistant Professor

YAMAMOTO Yasunori Plastic and Reconstructive Surgery

Assistant Professor

KOMURO Akito

Assistant Professor

KADOHIRA Mitsuhiro Plastic and Reconstructive Surgery

Assistant Professor

KANEKO Takayoshi

Plastic and Reconstructive Surgery

Assistant Professor

KOIZUMI Naoko

Plastic and Reconstructive Surgery

Assistant Professor

SUGISHITA Kazuyuki Plastic and Reconstructive Surgery

Assistant Professor

DAIZO Haruhisa

Plastic and Reconstructive Surgery

Assistant Professor

TAGUCHI Hisao

Plastic and Reconstructive Surgery

Assistant Professor

DOI Yujin

Plastic and Reconstructive Surgery

Assistant Professor

YAMASHITA Akiko

Plastic and Reconstructive Surgery

Assistant Professor

NISHIBU Yasuhiro

Plastic and Reconstructive Surgery

Assistant Professor

HIMI Yuji

Plastic and Reconstructive Surgery

Assistant Professor

MIYANAGA Toru

Plastic and Reconstructive Surgery

Assistant Professor

YAGISHITA Mikio

Plastic and Reconstructive Surgery

Plastic and Reconstructive Surgery

Keywords of Researchfibroblast, FGF receptor, pressure ulcer, TGF-beta, TGF-beta receptor, keratinocyte, wound healing, craniofacial surgery,zygoma, cleft lip, cleft palate, microtia, tissue expansion, crainofacial cleft, front-orbital advancement, microsurgery, freeflap, medialis pedis flap, adipofascial turu-over flap, burn reconstruction, burn wound management, MRI in congenital
anomaly

Outline of Research1) Wound healing
Promoting effects of wound dressings or drugs in wound healing process are studied clinicaly.
2) Tissue engineering
Regeneration of the skin and subcutaneous tissue using artificial materials are studied clinicaly and experimentally
3) Cranio-maxillo-facial surgery
New operative procedures in cranio-maxillo-facial fields are attempted to develope.

68

Publications
Originals
0450B001

A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient
urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.

0450B002

M.Yamashita, T.Akai, M.Kishibe, K.Shimada:One-piece bone flap osteotomy using thread wire saw for frontoorbital advancement with distraction osteogenesis in craniosynostosis, Child's Nervous System, 31:2;279-283,
2015.

0450B003

M.Yamashita, H.Daizo, A.Yamashita, M.Kishibe, K.Shimada:Correction of late posttraumatic enophthalmos using
an antral balloon, The Journal of Craniofacial Surgery, 26:4;1365-1369, 2015.

Reviews
0450C001

M.Yamashita:Rhinoplasty with autogenous cartilage grafts, Japanese journal of plastic surgery, 58:3;235-244, 2015.

0450C002

K.Shimada:Novel use of dermal substitute combined with negative pressure wound therapy, Japanese journal ofplastic surgery, 58:12;1333-1342, 2015.

Case Reports
0450D001

M.Yagishita, Y.Haseda, A.Sakagami, T.Takemura:A case of semi-specific myiasis with neurofibromatosis type 1,
Journal of Japan Society of Plastic and Reconstructive Surgery, 35:210-214, 2015.

Presentations at Conference
International Conference (Presentations)
0450I001

A.Sakagami, M.Yamashita, H.Daizo, A.Yamashita, M.Kishibe, K.Shimada, S.Kawakami:Correction of Late
Posttraumatic Enophthalmos Using an Antral Balloon, The 16th Congress of International Society of Craniofcial
Surgery, 2015, Maihama, 2015.

0450I002

A.Yamashita, M.Yamashita, K.Shimada, S.Kawakami:Three-Dimensional Computed Tomography Venography as a
Guide for Cranioplasty in Parietal Cephalocele, The 16th Congress of International Society of Craniofcial Surgery,2015, Maihama, 2015.

0450I003

M.Yamashita, A.Yamashita, M.Kishibe, K.Shimada, S.Kawakami:Incidence of lower eyelid complications after aransconjunctival approach: Influence of repeated incisions, The 16th Congress of International Society of
Craniofacial Surgery, Maihama, 2015.

69

0460

Department of Pediatric Surgery

Title

Name

Field of Specialization

Professor

KOHNO Miyuki

Pediatric surgery, Pediatric endoscopic surgery, Pediatric urolgy

Professor

IKAWA Hiromichi

Pediatric surgery, Defecatory function, Liver transplantation

Senior Assistant Professor

YASUI Yoshitomo

Pediatric surgery

Assistant Professor

KUWAHARA Tsuyoshi Pediatric surgery

Assistant Professor

TAKAHASHI
Sadayoshi

Pediatric surgery

Assistant Professor

SATOMI Miwa

Pediatric surgery

Assistant Professor

YOSHIZAKI Hisayoshi Pediatric surgery

Faculty

Keywords of Researchinguinal hernia, hydrocele of the cord, acute abdomen, quality of life, endoscopy, congestive gastroenteropathy, biriaryatresia, epidemiology, spontaneous cure, prevalence, neonatal surgery, vesicoureteral reflux, urostoma, intravenous
hyperalimentation, hydrocele testis, cryptorchism, appendicitis, anorectal malformation, endoscopic surgery, gastroesophageal reflux, liver transplantation, pediatric surgical common disease, natural history, pediatric solid malignant tumor,
pediatric urology, phimosis, intestinal stoma,

Outline of Research
Hemodynamic evaluation of PDA flow to decide the optical timing for radical operation of congenital diaphragmatic hernia.
The importance of rectal branch to induce high amplitude propagated colonic contraction.
Clinical study of pediatric endoscopic surgery.
Histochemical study of extracellular matrices which accelerate the hepatic fibrosis of biliary atresia.

Publications
Originals
0460B001

H.Yoshizaki, S.Okuda:Large-scale analysis of evolutionary histories of phosphorylation motifs in the humangenome, GigaScience, 4:21;1-6, 2015.

0460B002(M.Yagi), M.Kohno, K.Asagiri, T.Ikeda, T.Okada, S.Kanada, S.Kawashima, Y.Goto, S.Takano, M.Yasufuku,
M.Wada:Twenty-year trends in neonatal surgery based on a nationwide Japanese surveillance Program, PediatricSurgery International, 31:955-962, 2015.

0460B003

H.Yoshizaki, Y.Kuwajima, H.Minato, E.Kiyokawa:Regulation of Ripply1 expression in MDCK organoids,
Biochemical and Biophysical Research Communications, 468:1-2;337-342, 2015.

70

Presentations at Conference
International Conference (Presentations)
0460I001

H.Takada, H.Yoshizaki, E.Kiyokawa:In vivo imaging using a two-photon microscope in the mouse intestine,
International Symposium on Multi-dimensional Fluorescence Live Imaging of Cellular Functions and Molecular
Activities, Kyoto, 2015.

0460I002

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

71

0470

Department of Ophthalmology

Faculty
Title

Name

Field of Specialization

Professor

SASAKI Hiroshi

cataract, epidemiology, uveitis, electromagnetic ocular injury

Professor

KUBO Eri

cataract, oxidative stress and eye disease, diabetic eye complication

Professor

KITAGAWA Kazuko

Professor(Additional Post)

KOJIMA Masami

Associate Professor

FUKUDA Masamichi

ocular pharmacdogy, intraocular, penetration

Senior Assistant Professor

KAWAKAMI Yutaka

cataract

Assistant Professor

ARIMOTO Atsushi

macular degeneration

Assistant Professor

OSADA Hiromi

cataract, ophthalmology, macular degeneration

Assistant Professor

SHIBATA Shinsuke

cataract, ophthalmology, oxidative stress and eye disease

Assistant Professor

SHIBATA Naoko

cataract, ophthalmology, oxidative stress and eye disease

Assistant Professor

TAKAHASHI Yorikocataract

Assistant Professor

HATSUSAKA Natsuko ophthalmological optics, epidemiology

Assistant Professor

FUJITA Nobuyuki

ocular infection, Sjoegren's syndrome, keratoconjunctivitis sicca,
lacrimal fluid, proteomics
cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

uveitisKeywords of Researchproteomics, cataract classification, corneal epithelium, crystallin lens, dry eye, glaucoma, image analysis, lens sectioning
technique, melanin, ocular toxicology, Scheimpflug photography, tear secretion, UV-B, UV-induced ocular disease, UVdosimetry, lens organ culture, age related cataract, cataract epidemiology, cytotoxicity, fluoroquinolone, herapetic keratitis,
intraocular drug dynamics, lens epithelium, light scattering, retroillumination image, Sjogren’s syndrome, threedimentional
image, V-E, intraocular lens(IOL), cell culture

Outline of Research
There are five major themes for research in our department including: 1) ophthalmic epidemiology, 2) clinical research for
crystalline lens and intraocular lens (IOL), 3) basic research of cataract, 4) clinical research for keratoconjunctival diseases
and 5) ophthalmic pharmacology. Concerning 1), we have performed epidemiological studies in climatically different places(Ishikawa and Kagoshima, Japan, Singapore, Iceland, China and Tanzania). These studies have included prevalence,incidence and risk factors of cataract, pterygium, high myopia, glaucoma and age-related macular degeneration. For 2), we
have worked on image analysis of the crystalline lens, drew up a new classification system for cataract, and done researchon visual performance in cataractous eye and IOL. Regarding 3), we have evaluated effects of anti-cataractous drugs using
animal models and also investigated the mechanism of posterior capsular opacity (PCO). Development of a preventative
drug for PCO is undergoing. Considering 4), a new precious and simple technique for diagnosis of Sjogren's syndrome using
proteomics of tears is under development. Clinical research for diagnosis and treatment for ophthalmic infective diseases isalso underway. And for 5), ocular dynamics of eye drops, effectiveness and toxicity of eye drops, and a new method formeasuring corneal damage in vivo are all being investigated.

72

Publications
Originals
0470B001

M.Fukuda, H.Sasaki:The transcorneal penetration of commercial ophthalmic formulations containing timolol
maleate in rabbit eyes, Journal of Ocular Pharmacology and Therapeutics, 31:1;57-60, 2015.

0470B002(H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii:Rapid survey of four asp
isomers in disease-related proteins by LC-MS combined with commercial enzymes, Analytical Chemistry, 87:561568, 2015.

0470B003

M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki, H.Sasaki:
Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40 GHz),
Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.

0470B004

S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki:Visual acuity and contrast
visual acuity predicted from cataract type, The Journal of the Japanese Society for Cataract Research, 27:68-73,
2015.

0470B005(K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property
measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.

0470B006

M.Fukuda, H.Sasak:Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing,
Journal of Ocular Pharmacology and Therapeutics, 31:9;536-540, 2015.

0470B007

Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki:Optical simulation forsubsurface nanoglistening, Journal of Cataract and Refractive Surgery, 41:193-198, 2015.

Reviews
0470C001(K.Minami), K.Miyata, N.Nagai, H.Sasaki:Use of a warmed ophthalmic viscoelastic device to accelerate theunfolding of 1-piece intraocular lenses in the capsular bag, Journal of Cataract & Refractive surgery, 41:23322333, 2015.

0470C002(Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.

0470C003

H.Sasaki:Update no multifocal intraocular lenses' development, Journal of Japanese Ophthalmological Society,
119:1;3-5, 2015.

Case Reports
0470D001

H.Minato, E.Kinoshita, S.Nakada, T.Nojima, M.Tanaka, K.Usuda, M.Sagawa, H.Iwao, M.Tanaka, M.Doai,
T.Takahashi, N.Shibata:Thymic lymphoid hyperplasia with multilocular thymic cysts diagnosed before the Sjögren
syndrome diagnosis, Diagnostic Pathology, 10:103-108, 2015.

Presentations at Conference
International Conference (Presentations)
0470I001

H.Sasaki:Standardized classifications and severity scales of cataract , Asia Arvo, Yokohama, 2015.

0470I002

E.Kubo:Regulation of EMT and its possibility for suppression of PCO, Asia Arvo, Yokohama, 2015.

0470I003

E.Kubo:The microRNA regulates the lens development and differentiation, Asia Arvo, Yokohama, 2015.

0470I004

Y.Takahashi:Optical simulation of water clefts, Asia Arvo, Yokohama, 2015.

73

0470I005(Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe,
M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with manycore architecture based computing, URSI AT-RASC, Canary Istands, 2015.

0470I006

H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki, E.Kubo:
Effect of forward light scattering on visual function in eyes with cortical cataract, Association for Research in
Vision and Ophthalology, Denver, 2015.

0470I007T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin
expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision andOphthalology, Denver, 2015.

0470I008

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lensepithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision andOphthalology, Denver, 2015.

0470I009

Y.Seki, T.Shibata, Y.Yabata, M.Sasaki, H.Osada, T.Saruta, H.Asano, E.Kubo, A.Sanyiwa, H.Sasaki:Prevalence of
pinguecula in children living in rural Tanzania, Association for Research in Vision and Ophthalology, Denver, 2015.

0470I010

H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki, E.Kubo:
Effect of forward light scattering on visual function ineyes with cortical cataract, Association for Research in Vision
and Ophthalology, Denver, 2015.

0470I011(B.Chhunchha), E.Kubo, DP.Singh:Nrf2 Accelerater Oxidative Stress And Lens Epithelial Cell Death ThroughInduction of KLF9-Driver Repression of Prdx6 In Response To Excessive Oxidative Load, Association for
Research in Vision and Ophthalology, Denver, 2015.

0470I012

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

0470I013

H.Sasaki, E.Shibuya, M.Takahashi, N.Shibata, Y.Takahashi, S.Shibata, T.Shibata, N.Mita, E.Kubo:Effect of forward
light scattering on visual function in eyes with retrodots, XXXIII Congress of the RSCRS, Barcelona, 2015.

0470I014(Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal
dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,First PEM International Workshop in Kyoto, Kyoto, 2015.

0470I015

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lensepithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.

0470I016

N.Mita, M.Sasaki, Y.Takahashi, Y.Seki, A.Okamoto, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Higher-orderaberrations in Japanese eyes with cataract and eyes with aspherical intraocular lenses, The 3rd International
Conference on the Lens 2015, Kona, 2015.

0470I017

S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Human age related cataract and decorin:correlations among opacity severity, age and decorin expression, The 3rd International Conference on the Lens
2015, Kona, 2015.

0470I018

H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.

0470I019

E.Shibuya, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, T.Shibata, E.Kubo, H.Sasaki:Influence on visual function by
high-order aberration, forward and backward light scattering in eyes with nuclear opacity, The 3rd International
Conference on the Lens 2015, Kona, 2015.

0470I020

N.Hatsusaka, H.Osada, E.Shibuya, A.Okamoto, M.Sasaki, M.Takahashi, A.Nakano, Y.Seki, E.Kubo, H.Sasaki:
Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4 years postexposure, The 3rd International Conference on the Lens 2015, Kona, 2015.

0470I021

H.Sasaki, H.Asano, T.Hiraoka, H.Osada, T.Shibata, M.Sasaki, Y.Seki, T.Saruta, F.Fujikake, Y.Tabata, T.Oshika,
A.Sanyiwa:Mopia and related factors in Tanzanian adults, The 3rd International Conference on the Lens 2015,
Kona, 2015.

74

0470I022

T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelialmesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.

75

0475

Department of Otorhinolaryngology

Title

Name

Field of Specialization

Professor

MIWA Takaki

Otorhinolaryngology, Head and Neck Surgery

Professor

SUZUKA Yuko

Otology, Auditory physiology, Equilibrium neuroscience

Associate Professor

SHIGA Hideaki

Rhinology, Olfactory disorders

Senior Assistant Professor

MIYAZAWA Toru

Otorhinolaryngology

Senior Assistant Professor

TERAGUCHI Kanako Rhinology, generel otology

Assistant Professor

YAMAMOTO Junpei

General otorhinolaryngology, Olfactory disorders

Assistant Professor

KINOSHITA Yuko

Otorhinolaryngology

Assistant Professor

NODA Takuya

General otorhinolaryngology

Assistant Professor

YAMADA Kentaro

General otorhinolaryngology

Faculty

Keywords of Researcholfactory disorder, molecular imaging, virtual education for endoscopic nasal surgery, navigation surgery, audiology, sleep
apnea & snoar surgery

Outline of Research
Basic and clinical research for diagnosis and treatment of olfactory disorders(Miwa, Shiga, Teraguchi, Yamamoto, Yamada,Noda, Harita)
New educational system for endoscopic sinus surgery(Miwa , Shiga, Teraguchi)
Auditory central functional imaging with MEG(Suzuka, Teraguchi)
Clinical research for snoar and sleep apnea(Miwa, Sakai)

Publications
Originals
0475B001

T.Noda, K.Yamada, J.Yamamoto, T.Miwa, T.Tutumiuti, Y.Shimode, H.Thuzi:A case of mammary analogue
secretory carcinoma with sarcomatoid change, Stomato-pharyngology, 28:2;137-141, 2015.

0475B002(T.Tokunaga), M.Sakashita, T.Haruna, D.Asaka, S.Takeno, H.Ikeda, T.Nakayama, N.Seki, S.Ito, J.Murata,
Y.Sakuma, N.Yoshida, T.Terada, I.Morikura, H.Sakaida, K.Kondo, K.Teraguchi, M.Okano, N.Otori, M.Yoshikawa,
K.Hirakawa, S.Haruna, T.Himi, K.Ikeda, J.Ishitoya, Y.Iino, R.Kawata, H.Kawauchi, M.Kobayashi, T.Yamasoba,
T.Miwa, M.Urashima, M.Tamari, E.Noguchi, T.Ninomiya, Y.Imoto, T.Morikawa, K.Tomita, T.Takabayashi,
S.Fujieda:Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study, Allergy,
70:8;995-1003, 2015.

76

Reviews
0475C001

H.Shiga, T.Miwa:Nasal drug delivery facilitates molecular imaging of olfactory disorders., Nihon Bika Gakkai Kaishi(Japanese Journal of Rhinology), 54:1;47-51, 2015.

0475C002

H.Shiga, T.Miwa:Epidemiology of Olfactory Disoders, Progress in Medicine, 35:4;619-622, 2015.

0475C003

H.Shiga, T.Miwa:Improving effects of internasal insulin via olfactory nerve pathway on congnitive impairment,
Progress in Medicine, 35:4;701-704, 2015.

Others0475F001

T.Miwa, J.Yamamoto, K.Teraguchi, Y.Kinoshita, K.Yamada, T.Noda, M.Harita, H.Shiga, E.Sugiyama,
K.Ono:Changes in smell and taste function in the elderly, Chemical Senses, 40:3;261, 2015.

Presentations at Conference
International Conference (Key Note Lecture)
0475G001

T.Miwa:Change in olfactory function in the elderly and anti-aging., 17th Asian Research Symposium in Rhinology,
Beijin, 2015.

International Conference (Synposium)
0475H001

T.Miwa:Treatment of patients with olfactory dysfunction due to chronic rhinosinusitis., 16th World Congress of
Rhinology, Sao Paulo, 2015.

0475H002

H.Shiga, M.Furukawa, T.Miwa:When is the right time to start doctoral research in surgical residency? , The 32nd
Congress of the Pan-Pacific Surgical Association Japan, Honolulu, 2015.

0475H003

T.Miwa:Olfactory impairment in elderly., 13th Japan-Taiwan Conference on Otolaryngology-Head and Neck
Surgery, Tokyo, 2015.

International Conference (Presentations)
0475I001

H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory
nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.

0475I002

T.Noda:Effect of kampo medicine "Tokishakuyakusan" on olfactory epithelium in olfactory-impaired mice., 16th
World Congress of Rhinology, Sao Paulo, 2015.

0475I003

K.Yamada:Outcomes of olfactory dysfunction in chronic rhinosinusitis., 16th World Congress of Rhinology, Sao
Paulo, 2015.

0475I004

M.Harita, T.Hiraba, K.Teraguchi, J.Yamamoto, T.Miyazawa, H.Shiga, Y.Suzuka, T.Miwa:Two cases ofglomangiopericytoma in nasal cavity, The 32nd Congress of the Pan-Pacific Surgical Association Japan, Honolulu,
2015.

0475I005

Y.Nakamura, T.Noda, K.Yamada, K.Teraguchi, H.Shiga, T.Miwa:Endscopic vasculized nasoseptal flap repair of
cerebrospinal fluid leak to anterior skull base meningocele, The 32nd Congress of the Pan-Pacific Surgical
Association Japan , Honolulu, 2015.

0475I006

M.Harita, T.Hiraba, K.Teraguchi, J.Yamamoto, T.Miyazawa, H.Shiga, Y.Suzuka, T.Miwa:Two cases ofglomangiopericytoma in nasal cavity., 13th Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery,Tokyo, 2015.

77

0485

Department of Head and Neck Surgery

Faculty
Title

Name

Field of Specialization

Professor

TSUJI Hiroyuki

Head and neck oncology, Head and neck surgery

Senior Assistant Professor

SHIMODE Yuzo

Head and neck oncology, surgery, Thyroid gland tumor research

Keywords of Researchhead and neck cancer, deglutition functional disorder, lymph node dissection, thyroid papillary carcinoma, fine needle
aspiration cytology, chemoradiotherapy

Outline of Research
Development of surgical procedure for severe dysphagia (Tsuji, Shimode)
New system for fine needle aspiration cytology in the medical equipment field by industry-academia-government
cooperation (Tsuji, Shimode)
Clinical study of cervical lymph node metastasis from thyroid carcinoma and the applicate of neck dissection (Tsuji,
Shimode)Clinical study to evaluate response to chemoradiotherapy in lymph node metastasis (Tsuji, Shimode)

Publications
Originals
0485B001

T.Noda, K.Yamada, J.Yamamoto, T.Miwa, T.Tutumiuti, Y.Shimode, H.Thuzi:A case of mammary analogue
secretory carcinoma with sarcomatoid change, Stomato-pharyngology, 28:2;137-141, 2015.

0485B002

M.Matoba, H.Tuji, Y.Shimode, T.Kondo, K.Oota, H.Tonami:Lesion regression rate based on RECIST: predictionof treatment outcome in patients with head and neck cancer treated with chemoradiotherapy compared with FDG
PET-CT, Journal of Radiation Research, 56:3;553-560, 2015.

Presentations at Conference
International Conference (Presentations)
0485I001

Y.Shimode, H.Tsuji, M.Takaba:The "SONAVIA" and "SONAVIA Lock-on System" as Assistive Devices for Fine
Needle Aspiration Biopsy Cytology for Thyroid Nodular Lesions and Cervical Lymph Nodes, The 32nd Congress of
the Pan-Pacific Surgical Association, Honolulu, 2015.

0485I002

Y.Shimode, H.Tsuji, M.Takaba:The "SONAVIA" and "SONAVIA Lock-on System" as Assistive Devices for Fine
Needle Aspiration Biopsy Cytology for Thyroid Nodular Lesions and Cervical Lymph Nodes, 1st Congress of AsiaPacific Society of Thyroid Surgery, Seoul, 2015.

78

0490

Department of Dermatology

Faculty
Title

Name

Field of Specialization

Professor

MOCHIZUKI Takashi Medical mycology, Dermatomycosis

Associate Professor

NISHIBU Akiko

Associate Professor

WATANABE Seiji

Senior Assistant Professor

TAKEDA Kiminobu

Medical mycology

Senior Assistant Professor

ISHIZAKI Yasuko

Dermatopathology, cutaneous malignant tumor

Senior Assistant Professor

FUJII Toshiki

Dermatopathology

Assistant Professor

ANZAWA Kazushi

Medical mycology

Assistant Professor

USHIGAMI Tsuyoshi

Medical mycology

Assistant Professor

SHIMADA Toshitsugu Dermatology

Immunology

Keywords of Research
fungi, dermatophytes, Candida speｃies, Sporothrix species, dematiaceous fungi, mitochondrial DNA, ribosomal DNA,phylogeny, taxonomy, molecular epidemiology, molecular typing, electron microscopy, dermatopathology, skin tumor,
immunopathology, immunology, Langerhans cell,

Outline of Research
Research activities in the Department of Dermatology are mainly in the fields of cutaneous mycosis and medical mycology.
We introduced a nail drilling method for onychomycosis, to improve the methods of sampling, diagnosis and treatment by
antimycotics. For tinea capitis and tinea corporis spreading over wrestling, judo and sumo wrestlers, we support
dermatologists for identifying the causative fungi, Trichophyton tonsurans, and collect the nationwide epidemiological data.
We try to find an effective infection control system combining with a hairbrush sampling method and antimycotics to theepidemics.
In the field of basic mycology, a new technique based on the analysis of intergenic regions of certain genomes are found to
be useful to detect intra-species variations of T. mentagrophytes. Besides, the other aim of our research is to disclose thephylogenetic relationships of Trichophyton species based on multi-locus gene analysis and mating tests, and to understandthose species as they are.
In the most recent years, we began to study the pathophysiology of deep tissue injury, which is an uncommon clinical typeof decubitus after surgical operations.

Publications
Originals
0490B001(R.Kano), C.K.-M.Tsui, R.C.Hamelin, K.Anzawa, T.Mochizuki, K.Nishimoto, M.Hiruma, H.Kamata,A.Hasegawa:The MAT1-1:MAT1-2 ratio of sporothrix globosa isolated in Japan, Mycopathologia, 179:81-86,
2015.

0490B002(T.Tsukatani), H.Ogawa, K.Anzawa, E.Kobayashi, H.Hasegawa, K.Makimura, T.Yoshizaki, N.Ueda:Schizophyllum
commune-induced allergic fungal rhinosinusitis and sinobronchial mycosis, Medical Mycology Case Reports, 8:1013, 2015.

79

0490B003(S.Yamada), K.Anzawa, T.Mochizuki:Survey of dermatophyte infection in cats and dogs in the Fukui region ofJapan, 14:4;166-170, 2015.

0490B004(T.Iwanaga), K.Anzawa, T.Mochizuki:An investigation of the clinical practice for dermatophytosis treatment using
reimbursement data from health insurance societies in Japan, The Japanese Journal of Dermatology, 125:22892299, 2015.

Reviews
0490C001

T.Mochizuki, K.Takeda, K.Anzawa:Molecular markers useful for epidemiology of dermatophytoses, Journal of
Dermatology, 42:232-235, 2015.

0490C002(A.Chakrabarti), A.Bonifaz, M.Clara G.Galhardo, T.Mochizuki, Y.Song:Global epidemiology of sporotrichosis ,Medical Mycology , 53:3-14, 2015.

0490C003

T.Mochizuki:Dermatomycoses-Future Trend, 35:12;1847-1852, 2015.

Case Reports
0490D001

H.Mochizuki, T.Ushigami, T.Fujii, T.Mochizuki, N.Wakamatu:A case of angiolemyoma arising on the right heel,
14:4;183-187, 2015.

0490D002

K.Takeda, H.Mochizuki, Y.Sakata, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki, H.Kanakawa, M.Yanagihara:Acase of widespread tines corporis caused by Trichophton tonsurans mimicking atopic dermatitis, Journal ofpediatric dermatology, 34:2;29-33, 2015.

0490D003(A.Takeuchi), K.Anzawa, T.Mochizuki, K.Takehara, Y.Hamaguchi:Chromoblastomycosis caused by Phialophoraverrucosa on the hand, The European Journal of Dermatology , 25:3;274-275, 2015.

0490D004(M.Inaoki), C.Nishijima, M.Miyake, T.Asaka, Y.Hasegawa, K.Anzawa, T.Mochizuki:Case of dermatophyte abscesscaused by Trichophyton rubrum: a case report and review of the literature, Mycoses, 58:318-323, 2015.

0490D005

Y.Sakata, A.Kitayama, R.Yoshimura, K.Anzawa, T.Fujii, K.Fujimoto, H.Yokoyama, T.Mochizuki:Case of cutaneous
phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient, Journal of Dermatology,
42:3;263-266, 2015.

0490D006

K.Tsujioka, R.Tanaka, K.Anzawa, H.Ogura:A case of cutaneous phaeophomycosis caused by exophiala lecaniicorni showing a seasonal fluctuation of skin lesions, Medical Mycology Journal, 56:4;117-121, 2015.

Others
0490F001

T.Mochizuki :Frontline of dermatomycology research is just in front of us! , Journal of Dermatology, 42:231, 2015.

Presentations at Conference
International Conference (Presentations)
0490I001

K.Takeda, Y.Sakata, J.Watanabe, T.Ushigami, A.Nishibu, K.Anzawa, T.Mochizuki:Molecular polymorphism of
Trichophyton rubrum strains cultured from a Japanese patient with multiple lesions based on analysis of the nontranscribed spacer (NTS) region of ribosomal RNA gene, 19th ISHAM Congress in Melbourne, Melbourne, 2015.

80

0500

Department of Urology

Faculty
Title

Name

Field of Specialization

Professor

MIYAZAWA Katsuhito kidney stone disease, endourology, prostate cancer

Professor

TANAKA Tatsuro

kidney transplantation, endourology

Professor

SUZUKI Koji

kidney stone disease, kidney transplantation, hyperparathyroidism

Senior Assistant Professor

CHIKAZAWA Ippei

general urology

Senior Assistant Professor

MORITA Nobuyo

general urology

Assistant Professor

SUGA Koudai

general urology

Assistant Professor

TACHIBANA
Hiromichi

general urology

Assistant Professor

TOKUNAGA Kousuke general urology

Assistant Professor

NAKAI Dan

general urology

Assistant Professor

INOUE Shinya

general urology

Assistant Professor

NAKAZAWA Yusuke

general urology

Keywords of Researchchronic renal failure, renal transplantation, acquired cystic disease of the kidney, secondary hyperparathyroidism, acuterejection, immosuppression, renal stone, ESWL, TUL, endourology, calcium oxalate, glycosaminoglycans, heparan sulfate,crystal matrix protein, prothrombin, scanning microscopy, renal cell carcinoma, flow cytometry, BPH, prostatic cancer,
bladder cancer, p53, urinary incontinence,

Outline of Researchclinical research on renal transplantation, mechanism of urolithiasis

Publications
Originals
0500B001

N.Morita, S.Kuwasaki, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, I.Chikazawa, T.Tanaka, K.Miyazawa:Clinicalexperience of sunitinib in patients with advanced renal cell carcinoma, Japanese journal of urological surgery,
28:11;1813-1817, 2015.

0500B002

Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo,
K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.

Case Reports
0500D001

I.Chikazawa, S.Inoue, Y.Nakazawa, D.Nakai, H.Tachibana, K.Suga, N.Morita, T.Tanaka, K.Miyazawa, K.Sato:A
case of mucinous tubular and spindle cell carcinoma, Japanese journal of urological surgery, 28:1;99-102, 2015.

81

Presentations at Conference
International Conference (Presentations)
0500I001

K.Miyazawa:JUA Guidelines on Urolithiasis 2013 edition, Advancements in Urology2015 - an AUA/JUA
Symposium, Honololu, 2015.

0500I002

K.Miyazawa:Stone controversy: Lower pole stones and proximal ureteral stones., Advancements in Urology2015an AUA/JUA Symposium, Honololu, 2015.

0500I003

K.Miyazawa:Case-Based discussion: Challenging stone cases., Advancements in Urology 2015 - an AUA/JUA
Symposium, Honololu, 2015.

0500I004

S.Inoue:Stone Controversy-Ureteral stent after URS for proximal ureteral stone., Advancements in Urology 2015 an AUA/JUA Symposium, Honololu, 2015.

0500I005

Y.Nakazawa:SWL and Endourology (PCNL or URS) for proximal ureteral stone?, Advancements in Urology 2015 an AUA/JUA Symposium, Honololu, 2015.

0500I006

K.Miyazawa:Role of protease-activated receptors for calcium oxalate stone formation in tubular epithelial cells.,
USANZ2015 68th Annual Scientific Meeting, Adelaide, 2015.

82

0510

Department of Obstetrics and Gynecology

Faculty
Title

Name

Field of Specialization

Professor

SASAGAWA Toshiyuki

Gynecologic Pathology, Tumor Virology, Sexually Transmitted
Infection Research, Immunology

Senior Assistant Professor

OKA Yasuko

perinatal medicine, reproductive medicine

Senior Assistant Professor

TAKAGI Hiroaki

perinatal medicine, reproductive medicine, gynecologic oncology

Senior Assistant Professor

TOMIZAWA Hideki

perinatal medicine, reproductive medicine

Senior Assistant Professor

FUJITA Satoko

perinatal medicine, reproductive medicine

Assistant Professor

SHIBATA Takeo

perinatal medicine,reproductive medicine

Assistant Professor

NEYATANI Natsuko

perinatal medicine, climacteric medicine

Assistant Professor

YAMAGUCHI Naotaka perinatal medicine

Assistant Professor

OSAKA Yasuhiro

perinatal medicine

Assistant Professor

SAKAMOTO Jinichi

perinatal medicine, reproductive medicine

Keywords of Research
hypothalamus-pituitary system, prenatal diagnosis, malignant tumor of female genital organs, fertilization and nidation,
postmenopausal osteoporosis, endothelin, corpus luteum insufficiency, hormone-replacement therapy, nutrition andmetabolism in pregnant women, abnormal sexual differentiation, toxikosis of pregnancy, myoma uteri, climacteric symptoms,
mechanism of abortion, endometriosis, HGF, cytokine, G-CSF, IL-6, ovulation, hemodynamics, vaginal agenesis

Outline of Research<Reproductive Endocrinology>(Ovarian function and Cytokines)
Mechanism of luteolysis regulated by IL-6
Mechanism of ovulation regulated by G-CSF and its clinical application(Water transport in the female genital tract)
Mechanism of aquaporin water channels in the ovary and oviduct(Ovulatory process and Ovarian blood flow)
Prediction of ovulation using ovarian blood flow measurement<Perinatology>(Mechanism of Labor pains)
Relation between labor pains and G-CSF, and its clinical application for the prediction of premature labor(Prenatal diagnosis for Fetus)
New method for fetal diagnosis using ultrasonography
Retrospective analysis for fetal MRI findings, compared with pathological and neonatal diagnosis(Prognostic factor for early pregnant loss)
Analysis for hCG, Progesterone and G-CSF as prognostic factor for early pregnant loss

83

Presentations at Conference
International Conference (Presentations)
0510I001

H.Takagi, T.Sasagawa, T.Shibata, S.Makinoda:Usefulness of PET/CT SUV and prognostic factors in patients withendometrial cancer (endometrioid adenocarcinoma), FIGO 2015, 21st Gynecology & Obstetrics World Congress,
Vancouver, 2015.

0510I002

Y.Oka, S.Makinoda:A trial of preoperative diagnosis of uterine sarcoma using tumor signal intensity at Magnetic
Resonance Imaging (MRI)), 25th World Congress on Ultrasound in Obstetrics and Gynecology, Montreal, 2015.

0510I003

Y.Osaka, T.Maehama, H.Ito, H.Kobayashi, T.Sasagawa:An accuracy of hybrid capture-2 (HC-2)and cobas HPV
tests used for cervical cancer screening in Japan, Internatioal papillomavirus conference, Lisbon, 2015.

0510I004

T.Shibata, S.Makinoda:Change in myeloperoxidase index in polymorphonuclear neutrophils during the normal
menstrual cycle, FIGO 2015, 22st Gynecology & Obstetrics World Congress, Vancouver, 2015.

0510I005

H.Takagi, T.Sasagawa, T.Shibata, S.Makinoda:Usefulness of PET/CT SUV and prognostic factors in patients withendometrial cancer (endometrioid adenocarcinoma), FIGO 2015, 21st Gynecology & Obstetrics World Congress,
2015.

84

0520

Department of Anesthesiology and Perioperative Medicine

Faculty
Title

Name

Field of Specialization

Professor

TSUCHIDA Hideaki

Cardiovascular effects of anesthetics

Senior Assistant Professor

OGAWA Masao

Clinical anesthesia, Palliative medicine

Senior Assistant Professor

KIDA Hiromasa

Clinical anesthesia, Pediatric anesthesia, Shock

Senior Assistant Professor

HONMA Keiko

Clinical anesthesia, Palliative medicine

Assistant Professor

ARAKI Hideharu

Clinical anesthesia

Assistant Professor

TAKANO Mami

Clinical anesthesia

Assistant Professor

TANAKA Yasunori

Clinical anesthesia

Assistant Professor

HIRAMATSU Akiko

Clinical anesthesia

Assistant Professor

HIRAMATSU Toshiaki Clinical anesthesia, Vascular reactivity

Assistant Professor

TAKAHARA Asami

Clinical anesthesia

Assistant Professor

MURATA Yuriko

Clinical anesthesia

Assistant Professor

MORIKAWA Takanori Clinical anesthesia

Assistant Professor

YAMAOKA Yuko

Clinical anesthesia, Palliative medicine

Assistant Professor

YUGI Haruka

Clinical anesthesia

Assistant Professor

UEDA Keiko

Clinical anesthesia

Keywords of Researchanesthetic volatile, anesthetic intravenous, cardiovascular system, vascular smooth muscle, endothelium, palliative care,postoperative pain relief, sepsis, inducible nitric oxide synthase, nitric oxide

Outline of Research
In a clinical setting, we have been studying the effects of various anesthetics or vasoactive drugs on hemodynamics inperioperative patients. Especially, we are now studying the effects of beta1-selecive antagonists on hemodynamics andprognosis in patients undergoing noncardiac surgery. In the laboratory, we have examined the effects of septic shock onvasoreactivity in the rat thoracic aorta or the mesenteric arteriole.

Publications
Reviews
0520C001

M.Ogawa, H.Tsuchida:Present situation and problems of perioperative risk stratification models, Journal of
Kanazawa Medical University, 40:2・3;149-153, 2015.

Case Reports
0520D001(A.Shirai), M.Ogawa, K.Hirota, T.Yoshizaki, K.Ogawa:Efficacy of jiinshihoto in patients with glossodynia andabnormal sensation in the throat : Three case reports, Journal of the Japan Society for Oriental Medicine, 66:1;2227, 2015.

85

Presentations at Conference
International Conference (Presentations)
0520I001

M.Ogawa, H.Tsuchida:Patient age influences the relationship between the Surgical Apgar Score and postoperative
major complications, Euroanaesthesia 2015 (European Society of Anesthesiology), Berlin, 2015.

86

0540

Department of Physical and Rehabilitation Medicine

Faculty
Title

Name

Field of Specialization

Professor

KAGECHIKA Kenjirehabilitation medicine, osteoporosis, disuse syndrome, higher brain
dysfunction

Keywords of Researchgait analysis, force plate, kinematic measurements, electromyogram, power spectrum, bone and joint problem, femoral neckfracture, low back pain, hemiplegia, paraplegia, osteoporosis, disphagia, instruction of ADL,

Outline of Research１）Using spectral analysis in the EMG frequency ,we will clarify the control in motor units of lower extremity muscles during
walking cycle.
２）For the purpose of developing the therapeutic exercise, we studying the sway paths of center of gravity for the patientwith osteoarthritis of the hip who underwent hip surgery．
３）We have made the clinical pathway of the patient with femoral neck fracture. Hereafter we are going to study about theoutcome, then to improve this clinical pathway, for the patient to return home with satisfaction.
４）We will establish the evaluation for dysphagia, analyzing results of videofluoroscopic and videoendoscopic examination ofswallowing. Secondly, we are going to establish the standard of indication for swallowing training.

Publications
Originals
0540B001

A.Kura, K.Sasaki, T.Kimura, A.Kobe, K.Kagechika:Kinematical characteristics of lower extremity in females withanterior cruciate ligament reconstruction during stair descent: Changes in joint ROM of the lower extremity ,Rigakuryoho Kagaku, 30:1;85-89, 2015.

0540B002

K.Okamoto, K.Nakatani, N.Sunahara, M.Notoya, K.Inoue, K.Kagechika:Effects of auditory stimulation by white
noise in the rehabilitation of unilateral spatial neglect patients, Journal of the Tsuruma Health Science Society,39:1;87-92, 2015.

Presentations at Conference
International Conference (Presentations)
0540I001

A.Kobe, N.Yamazaki, C.Yamamoto, Y.Funami, K.Kagechika, T.Maeno, P.T.Inaoka:Falls incidents between arehabilitation department and entire hospital:A five year comparative study, World Confederation for Physical
Therapy 2015, Singapore, 2015.

0540I002

Y.Izaki, K.Kyoda, K.Kagechika:Analysis of Kanji reading in a case of alexia with agraphia of Kanji in the lesion of
the left inferior temporal gyrus-Using the Sophia Analysis of Language in Aphasia(SALA)-, 9th World Congress of
the International Society of Physical and Rehabilitation Medicine, Berlin, 2015.

0540I003

K.Kagechika, T.Nakaki, M.Tsubokawa, A.Nakaki, Y.Takagi:Effect of rehabilitation fo blood cancer, 9th World
Congress of the International Society of Physical and Rehabilitation Medicine, Berlin, 2015.

87

0550

Department of Emergency Medicine

Faculty
Title

Name

Field of Specialization

Professor

WATOH Yukihiro

Emergency, Emergency medical syctem, Disaster Medicine

Senior Assistant Professor

MASHIBA Satoru

Emergency, Anaphylaxis

Assistant Professor

GOTO Tetsuro

Emergency

Assistant Professor

MURASAKA Kenshi

Emergency, Neurosurgery

Assistant Professor

MORITA Hideki

Emergency

Assistant Professor

WATANABE Atsushi

Emergency

Keywords of Research
acute poisoning, resuscitation, disaster medicine, emergency room, intensive care,

Outline of Research
Evaluative research of Emergency Medicine, EMS system, and Dsaster management.

Publications
Originals
0550B001(Y.Takei), T.Nishi, T.Kamikura, Y.Tanaka, Y.Wato, M.Kubo, M.Hashimoto, H.Inaba:Do early emergency calls
before patient collapse improve survival after out-of-hospital cardiac arrests?, Resuscitation, 88:20-27, 2015.

88

0570

Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

KANDA Tsugiyasu

Cardiovascular distase, Diabetes Mellitus, Mental distase

Senior AssistantProfessor(Additional Post)
Assistant
Professor(Additional Post)

TAKAHASHI
Masakatsu

clinical respiratory medicine, pulmonary tuberculosis

USUDA Daisuke

Keywords of Research
cytokine, myocarditis, atherosclerosis, chronic fatigue syndrome, immunotherapy,

Outline of Research
The main investigation in our department is to find the cytokine effect as the immunotherapy in the animal model or clinicalfield.
1. The treatment of heart failure with myocarditis in an animal model.
2. The treatment trial of cytokine regulation in the atherosclerosis.
3. The cytokine treatment against chronic fatigue syndrome.

Publications
Originals
0570B001

T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda,
S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.

89

0575

Department of Gastroenterological Endoscopy

Faculty
Title

Name

Professor

ITO Tohru

Associate Professor

Diagnosis for esophagus, gastro-intestine, colon, liver & bileductdisease. Endoscopical treatment of its disease, especially, superficial
type esophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KITAKATA Hidekazu Endoscopical treatment of its disease,especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer

Associate Professor

URASHIMA Sachio

Senior Assistant Professor

KAWAURA Ken

Assistant Professor

Assistant Professor

Assistant Professor

Assistant Professor

Field of Specialization

Diagnosis for esophagus, Hepato-biliary-pancreatic treatment

Diagnosis for esophagus, gastro-intestine, colon, disease.
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
HAMADA Kazu
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
AZUKISAWA Sadafumi Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
KOBAYASHI Rika
Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer
Diagnosis for esophagus, gastro-intestine, colon, disease.
OKAMURA Hideyuki Endoscopical treatment of its disease, especially, superficial typeesophageal cancer, early gastric cancer, early colon cancer

Keywords of Research
Endoscopy, Diaguosis, treatment, Esophagus, Stomach, Colon, ESD, EMR

Outline of Research
1.A study for endoscopical diagnosis of early digestive organ cancer.(Esophagus,Stomach,Colon)
2.A study for endoscopical treat ment of early digestive organ cancer. (Esophagus,Stomach,Colon)
3.A study for prediction of lymphnode metastasis which early diagestive organ cancer.(Esophagus,Stomach,Colon)

Publications
Originals
0575B001

K.Hamada, T.Itoh, H.Kitakata, K.Kawaura, S.Azukisawa, R.Itoh, H.Okamura, S.Urashima:Examination of dark
reddish-brown urine (RBU) caused by endoscopic submucosal dissection (ESD), ENDOSCOPIC FORUM fordigestive disease, 31:1;33-39, 2015.

0575B002

T.Itoh, H.Kitakata, S.Kinami, K.Kawaura, K.Hamada, S.Azukisawa, R.Itoh, K.Omote, T.Kosaka, M.A.Fujino:New
treatment strategy for submucosa-infiltrating gastric cancer without sentinel node metastasis: A pilot study oflaparoscopy-assisted endoscopic full-thickness resection in an IN VIVO porcine model., ENDOSCOPIC FORUM
for digestive disease, 31:1;17-26, 2015.

90

Presentations at Conference
International Conference (Synposium)
0575H001

T.Ito, K.Kawaura, S.Azukisawa, K.Hamada, H.Kitakata, R.Ito:Endoscopical diagnosis & treatment for
undifferentiated adenocarcinoma of stomach., The 17th Japan-Russia Endoscopy Symposium, Moscow, 2015.

International Conference (Presentations)
0575I001

T.Ito:Dianosis of SM gastric cancer and novel technology of EFTR for SM gastric cancer., Suegical endoscopy andmini-invasive surgery:state of the art, Firenze, 2015.

91

0580

Department of Oral and Maxillofacial Surgery

Faculty
Title

Name

Field of Specialization

Professor

SEGAMI Natsuki

oral and maxillofacial surgery, temporomandibular joint disorders, oral
cancer, orthognathic surgery

Associate Professor

MATSUMOTO Gouichi Bone Regeneration, Biomaterials, Oral Cancer

Associate Professor

ISHIBASHI Hiroaki

Oral tumor, Oral Pathology

Associate Professor

DEMURA Noboru

orthodontics, stomatology

Assistant Professor

KATO Koichiro

Oral tumor

Assistant Professor

HASUMOTO Miho

Orthodontics

Assistant Professor

KATO Takao

Oral cavity, Kampo medicines, Dental pharmacology

Keywords of Researchstomatology, oral and maxillofacial surgery, orthodontics, temporomandibular joint, arthroscopy, magnetic resonanceimaging, oral cancer, metastasis, orthognathic surgery, kampo medicines, dental pharmacology

Outline of Research
1. Basic and clinical research for disorders of temporomandibular joints.
2. Molecular biological research for growth and metastasis of tumors in oral region.
3. Pathophysiological research for abnormal development of oral and maxillofacial region.
4. Research for surgical orthognathics for jaw deformity.
5. Integration mechanisms of oral sensory information in the central nervous systems.
6. Studies on the pharmacological mechanism of Kampo medicines.

Publications
Originals
0580B001

G.Matsumoto, T.Ueda, Y.Sugita, K.Kubo, M.Mizoguchi, E.Kotani, N.Oda, Shin Kawamata, N.Segami,
H.Mori:Polyhedral microcrystals encapsulating bone morphogenetic protein 2 improve healing in the alveolar ridge,
Journal of Biomaterials Applications, 30:2;193-200, 2015.

92

University Hospital

0635

Hepatology

Faculty
Title

Name

Field of Specialization

Professor

TSUTSUMI Mikihiro

Mechanism of alcoholic liver disease

Professor

TSUCHISHIMA
Mutsumi

Anti-viral therapy of viral hepatitis

Associate Professor

TOSHIKUNI Nobuyuki Interventional therapy for hepatocellular carcinoma

Associate Professor

SHIROEDA Hisakazu Endoscopic therapy of early gastric cancer

Associate Professor

OZAKI Kazuaki

Mechanism of portal hypertention in alcoholic liver injury

Senior Assistant Professor

JOSEPH George

Mechanism of hepatic fibrosis

Senior Assistant Professor

HAYASHI Nobuhiko

Mechanism of nonalcoholic fatty liver disease

Senior Assistant Professor

SAITO Takashi

Treament for metabolic syndrome

Senior Assistant Professor

FUKUMURA Atsushi

Etiology and clinical feature of acute hepatitis

Keywords of Researchalcohol metabolism, alcoholic liver injury, carbohydrate deficient transferrin, cytochrome P4502E1, mitochondrial DNA
mutation, hepatic fibrosis, hepatic stellate cell, hepatocyte apoptosis, chemical carcinogenesis, non-alcoholicsteatohepatitis, FLS-ob mouse, metabolic syndrome, insulin resistance, leptin, adiponectin, oxidative stress, anti-oxidative
enzyme, chronic type C hepatitis, HCV-RNA genotype, interferon therary, chronic type B hepatitis, anti-viral treatment,
treatment of hepatocellular carcinoma, radiofrequency ablation, arterial infusion therapy, early gastric cancer, endoscopic
mucosal resection, endoscopic submucosal dissection, inflammatory bowel disease, ischemic colitis

Outline of Research
１ Basic and clinical study of digestive disease①Treatment for esophageal and gastric varices associated with portal hypertension②Hepatic support system for severe alcoholic hepatitis③Clinical feature and treatment for nonalcoholic steatohepatitis
２ Experimental study of alcoholic organ injury①Pathogenesis and treatment for alcoholic hepatitis②Pathogenesis of hepatic fibrosis induced by alcohol③Effect of alcohol on chemical carcinogenesis of the liver
３ Pathogenesis for nonalcoholic steatohepatitis

Publications
Originals
0635B001

N.Kawada, H.Uehara, T.Hosoki, M.Takami, H.Shiroeda, T.Arisawa, Y.Tomita:Usefulness of Dual-Phase F-18FDG PET/CT for Diagnosing Small Pancreatic Tumors, Pancreas, 44:4;655-659, 2015.

0635B002

M.Nakamura, T.Tahara, H.Shiroeda, K.Matsunaga, T.Otsuka, J.Yonemura, T.Shibata, T.Arisawa:The effect ofshort-term proton pump inhibitor plus anti-ulcer drug on the healing of endoscopic submucosal dissection-derived
artificial ulcer: A randomized controlled trial, Hepato-Gastroenterology, 62:137;219-224, 2015.

93

0635B003

N.Kawada, H.Uehara, S.Nagata, M.Tsuchishima, M.Tsutsumi, Y.Tomita:Imaging morphological changes of
intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but notwith development of pancreatic ductal adenocarcinoma, Pancreatology, 15:6;654-660, 2015.

0635B004

Y.Matsue, M.Tsutsumi, N.Hayashi, T.Saito, M.Tsuchishima, N.Toshikuni, T.Arisawa, J.George:Serum osteopontin
predicts degree of hepatic fibrosis and serves as a biomarker in patients with hepatitis C virus Infection, PLoS
One, 10:3;e0118744, 2015.

0635B005

N.Toshikuni, K.Ozaki, J.George, M.Tsutsumi:Serum endocan as a survival predictor for patients with livercirrhosis, Canadian Journal of Gastroenterology and Hepatology, 29:8;427-430, 2015.

0635B006

N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyltranspeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis andThrombosis, 22:10;1051-1060, 2015.

Reviews
0635C001

M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi:Toxic AGEs (TAGE) theory in thepathogenesis of NAFLD and ALD, International Journal of Diabetes and Clinical Researsh, 2:4;1-5, 2015.

94

0675

Health Evaluation Center

Faculty
Title

Name

Field of Specialization

Professor

ASAJI Takayoshi

Heartfailure

Professor

FURUTA Hisakazu

Clinical study on sleep-wake disorders

Assistant Professor

ISHIKAWA Kaori

Preventive medicine

Associate Professor

NAKANISHI Yumiko

Preventive medicine

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

NISHIJO Muneko

Environmental epidemiology, epidemiology of cadmium pollution

ISHIZAKI Masao

Occupational health, Epidemiology for cardiovascular disease

SAKURAI Masaru

Cardiovascular epidemiology, preventive cardiology

NAGASAWA Shinya

Cardiovascular epidemiology, preventive cardiology

Professor(Additional Post)
Associate Professor(Additional Post)
Associate Professor(Additional Post)
Associate Professor(Additional Post)
Assistant Professor

Keywords of Researchhealth examination, screening, metabolic syndrome, obesity, hypertension, insulin resistance, hyperlipidemia, smoking,alcohol intake, life style, stress, dietary habits, nutrient intake, exercise

Outline of ResearchStudies for improvement of total medical check system and method of health support.

Publications
Originals
0675B001

Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association ofcigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.

0675B002

K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.

0675B003

PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure andthe neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.

0675B004(A.Takazakura), M.Sakurai, Y.Bando, H.Misu, Y.Takeshita, Y.Kita, A.Shimizu, T.Hayakawa, K.Kato, S.Kaneko,
T.Takamura:Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic
nephropathy, Journal of Diabetes Investigation, 6:3;346-353, 2015.

0675B005

SY.Nagasawa, T.Ohkubo, K.Masaki, E.Barinas-Mitchell, K.Miura, T.Seto, A.El-Saed, T.Kadowaki, BJ.Willcox,
D.Edmundowicz, A.Kadota, RW.Evans, S.Kadowaki, A.Fujiyoshi, T.Hisamatsu, MH.Bertolet, T.Okamura,
Y.Nakamura, LH.Kuller, H.Ueshima, A.Sekikawa; ERA-JUNP Study Group:Associations between inflammatory
markers and subclinical atherosclerosis in middle-aged white,Japanese-American and Japanese men: The ERAJUMP study, Journal of Atherosclerosis Thrombosis, 22:6;590-598, 2015.

95

0675B006

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido,
H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal
dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.

0675B007(K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice forrenal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.

0675B008

N.Toshikuni,T.Asaji,Y.Nakanishi,SY.Nagasawa,H.Uenishi,M.Tsutsumi:Elevated serum gamma-glutamyltranspeptidase levels and fatty liver strongly predict the presence of carotid plaque, Journal of Atherosclerosis andThrombosis, 22:10;1051-1060, 2015.

0675B009(M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan(EPOCH?JAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-termrisks of subtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts inJapan., Hypertension, 65:3;517-524, 2015.

0675B010(T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima;
NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.

0675B011(HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo,
H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinateddibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.

0675B012

TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa,T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.

0675B013

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

0675B014(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular
dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.

0675B015(IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination forsurvival data, Biometrical Journal, 57:4;592-613, 2015.

0675B016(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause
mortality increased by environmental cadmium exposure in the Japanese general population in cadmium nonpolluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.

Reviews
0675C001(C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis ofprospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.

0675C002(K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.

Presentations at Conference
International Conference (Synposium)960675H001

M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.

0675H002

M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in theCadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.

International Conference (Presentations)
0675I001

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

0675I002

SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.

0675I003

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido,
Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22ndInternational Symposium on Shiftwork and Working Time, Elsinore, 2015.

0675I004

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

0675I005(TT.Pham), M.Nishijo, MT.Do, NT.Pham, VL.Hoang, HA.Tran, VL.Nguyen, NN.Tran, VK.Tran, TT.Dang,
TL.Nguyen, H.Nishijo, H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population
living near Bian Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium
on Halogenated Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.

0675I006

TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples ofmother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.

0675I007

M.Nishijo, TN.Nghi, PN.Thao, PT.Tai, AH.Tran, HV.Luong, H.Nishijo:Dioxin effects on groeth andneurodevelopment of infants and children in Vietnam., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vietnam, Hanoi, 2015.

97

Medical Research Institute7100

Department of Life Sciences

Faculty
Title

Name

Field of Specialization

Professor

TAKEGAMI Tsutomu

Molecular mechanism of flavivirus replication, interaction with hostcells and viral carcinogenesis

Professor

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor

TANAKA Keiko

Clinical neurology, Neuroimmunology

Associate Professor

OTA Takahide

Molecular analysis of the mechanism of cancer metastasis

Associate Professor

TASAKI Takafumi

Protein regulation by the post-translational modifications and its
underlying molecular mechanisms

Senior Assistant Professor

MIYAGOSHI Minoru

Cell biology

Senior Assistant Professor

TANIGUCHI Makoto

Molecular and Cellular Biology, Lipid Biochemistry

Keywords of Research
cancer, carcinogenesis, metastasis, cell transformation, gene expression, HCV, JEV, virus replication, RNAi, micro RNA,
centrosome, polyploid cells, polyploidization, triploid/tetraploid/octaploid cells, Meth-A cells, V79 cells, H-1(ES) cells,
RhoGDI, Rho family, epitherial/mesenchymal, transfection, RNA surveillance, nonsense mediated mRNA decay, mutation,
DNA microarray, transcriptome, proteome, apoptosis, ultra micro structure, mouse germ cells, DNA repair, fibroblast
growth factor, tumor growth angiogenesis, Ubiquitin-proteasome system, Autophagy

Outline of Research
１．Study on viral replication and pathogenicity
２．Molecular mechanism of carcinogenesis and metastasis
３．Research on plolyploidization and polyploid cells
４．Analyses of transcription and mRNA decay
５．Protein regulation by the post-translational modifications and its underlying molecular mechanisms

Books
7100A001(J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling thespecific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions(Angel Catalá), 91-128, America, 2015.

7100A002

T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus
Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.

7100A003(H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative
disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.

98

Publications
Originals
7100B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.

7100B002

J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.

7100B003(N.Tachibana), M.Kinoshita, F.Kametani, K.Tanaka, Y.Une, Y.Komatsu, Y.Kobayashi, S.Ikeda:Expression of Nmethyl-D-aspartate receptor subunits in the bovine ovum: Ova as a potential source of autoantigens causing antiNMDAR encephalitis., The Tohoku Journal of Experimental Medicine, 235:3;223-231, 2015.

7100B004(R.Matsuda), T.Kezuka, A.Umazume, Y.Okunuki, H.Goto, K.Tanaka:Clinical profile of anti-myeli oligodendrocyte
glycoprotein antibody seropositive cases of optic neuritis., Neuro-Ophthalmology, 39:5;213-219, 2015.

7100B005(H.Nakajima), M.Motomura, K.Tanaka, A.Fujikawa, R.Nakata, Y.Maeda, T.Shima, A.Mukaino, S.Yoshimura,
T.Miyazaki, H.Shiraishi, A.Kawakami, A.Tsujino:Antibodies to myelin oligodendrocyte glycoprotein in idiopathic
optic neuritis, BMJ Open, 5:4;1-4, 2015.

7100B006(RS.Tsuburaya), N.Miki, K.Tanaka, T.Kageyama, K.Irahara, S.Mukaida, K.Shiraishi, M.Tanaka:Anti-myelin
oligodendrocyte glycoprotein (MOG) antibodies in a Japanese boy with recurrent optic neuritis, Brain &Development, 37:1;145-148, 2015.

7100B007(S.Nukuzuma), S.Sugiura, K.Nakamichi, M.Kameoka, C.Nukuzuma, T.Tasaki, T.Takegami:Replication of IMR-32adapted JC virus clones in human embryonic kidney cells, Microbiology and Immunology, 59:4;238-242, 2015.

7100B008

T.Ota, M.Maeda, M.Okamoto, M.Tatsuka:Positive regulation of Rho GTPase activity by RhoGDIs as a result of
their direct interaction with GAPs, BMC Systems Biology, 9:3, 2015.

7100B009

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.

7100B010

M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acidsphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein innatural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.

7100B011

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7100B012

J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic
fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.

7100B013

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7100B014

F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial
learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.

7100B015

H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains,
Journal of Lipid Research, 56:8;1594-1605, 2015.

99

7100B016

Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to
cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.

Reviews
7100C001

K.Tanaka:Recent update on autoimmune encephalitis/encephalopathy, Clinical and Experimental
Neuroimmunology, 6:70-82, 2015.

7100C002(K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.

7100C003(K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematologicalmalignancies, Molecules and Cells, 38:6;482-495, 2015.

7100C004

Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.

Case Reports
7100D001(R.Matsumoto), N.Mikuni, K.Tanaka, K.Usami, K.Fukao, T.Kunieda, Y.Takahashi, S.Miyamoto, H.Fukuyama,
R.Takahashi, A.Ikeda:Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody,
Epileptic Disorders, 17:1;89-94, 2015.

7100D002(H.Yaguchi), K.Tsuzaka, S.Shirai, M.Niino, T.Takahashi, K.Tanaka, I.Yabe, H.Sasaki:Importance of T1-MRI enhanced pyramidal tracts in differential diagnosis as to paraneoplastic encephalomyelitis,
Clinical Neurology and Neurosurgery, 132:9-11, 2015.

7100D003

S.Nakada, H.Minato, T.Takegami, N.Kurose, H.Ikeda, M.Kobayashi, Y.Sasagawa, T.Akai, T.Kato, N.Yamamoto,T.Nojima:NAB2-STAT6 fusion gene analysis in two cases of meningeal solitary fibrous tumor/hemangiopericytoma
with late distant metastases, Brain Tumor Pathology, 32:4;268-274, 2015.

Short Communications
7100E001

K.Tanaka:Debate on the pathogenesis of paraneoplastic cerebellar degeneration with anti-Yo antibody:T-cellmediated or antibody mediated?, Clinical and Experimental Neuroimmunology, 6:3;222-224, 2015.

7100E002(M.Tanaka), M.Kinoshita, K.Tanaka:Corticosteroid and tacrolimus treatment in neuromyelitis optica relateddisorders., Multiple Sclerosis Journal, 21:5;669, 2015.

7100E003（M.Tanaka）, M.Kinoshita, JF.Foley, K.Tanaka, J.Kira, WM.Carroll:Body weight-based natalizumab treatment in
adult patients with multiple sclerosis, Journal of neurology, 262:3;781-782, 2015.

7100E004(M.Tanaka), M.Kinoshita, K.Tanaka:Anti-John Cunningham virus index in Japanese patients with multiple sclerosis
and neuromyelitis optica-related disorder., Clinical and Experimental Neuroimmunology, 6:3;309-311, 2015.

7100E005

M.Fujita-Nakata, R.Tomioka, K.Tanaka, M.Nakanishi, S.Nagayama, R.Takahashi, T.Machiya, T.Hamada,
M.Matsui:Intractable cough as Characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum
disorder., Multiple Sclerosis Journal, 22:4;576-577, 2015.

7100E006(H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the
mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.

Others
7100F001

K.Tanaka:Pathogenesis of autoantibodies in autoimmune encephalopathies, Annual report of the Japan Epilepsy
Research Foundation, 26:83-90, 2015.

100

Presentations at Conference
International Conference (Synposium)
7100H001

K.Tanaka, Yongzhi Li, N.Kato:Memory disturbance in mice treated with intraventricular administration of CSF
from NMDAR-encephalitis patients, The Lancet Neurology Autoimmune Disorders Conference, Balcerona, 2015.

International Conference (Presentations)
7100I001

K.Tsutsui, M.Fujita, T.Kanbayashi, M.Matsui, K.Tanaka.:Clinical features of anti-NMDAR antibody-positive
patients predominantly presenting with chronic psychosis and acute exacerbations., The Lancet Neurology
Autoimmune Disorders Conference, Balcerona, 2015.

7100I002

K.Tanaka, M.Fujita, K.Tsutsui, T.Kanbayashi, M.Matsui:Clinical Features of Anti-NMDAR Antibody-positive
Patients Predominantly Presenting Chronic Psychosis with Acute Exacerbations, 67th AAN Annual Meeting,Washington, 2015.

7100I003

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

7100I004

T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration ofmalignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.

101

7200

Department of Advanced Medicine

Title

Name

Field of Specialization

Professor(Additional Post)

OKAZAKI Toshiro

Hematology and Immunology, Hematology/Oncology

Professor

TAKEUCHI Masayoshi AGEs, Life style-related disease

Professor(Additional Post)

MOTOO Yoshiharu

Clinical Oncology, Gastroenterology, Cancer Cell Biology

Associate Professor

SHIMASAKI Takeo

Medical Oncology, Gastroenterology, BioInformatics

Associate Professor

NIIDA Yo

Genetic disease, Genetic diagnosis

Assistant Professor

UEDA Tadashi

cardiac muscle, lung, cell biology, cytochemistry

Assistant Professor

TAKATA Takanobu

Deveropment of the method for diacrisis and therapy of theintractable disease by 'Ptoteome Analysis'

Assistant Professor

SAKASAI Akiko

AGEs, Cell Biology

Assistant Professor

OZAKI Mamoru

cytogenetics, Molecular cytogenetics

Professor

TOMOSUGI Naohisa

Clinical Proteomics

Faculty

Keywords of Researchrenal cell carcinoma, cytogenetics, metalloproteinase, mesangial cell, renal disease, chronic renal failure, glomerulonephritis,
anti-aging, AGEs, heart failure, cardiomyopathy, nerohumoral factor, autoantibody, cell cycle, epigenetics, clinicaloncology, gastroenterology, tumor biology, genetic counseling, genetic service, prenatal diagnosis, congenital abnormality,
karyotype,

Outline of Research
１．Heart failure by autoimmune pathway related with G-protein
２．Study on hepcidin-25 as iron regulatory factor in the hemodialysis patient
３．The role of AGE in the prevention of lifestyle related disease
４．Clinical research for the diagnosis and treatment of pancreatic cancer
５．Development and clinical application of fetal DNA diagnosis using mother’s blood
６．Genetic diagnosis and analysis of hereditary developmental disability
７．Development of molecular method to detect the abnormality of chromosome, and risk evaluation about balance type ofreciprocal translocation

Books
7200A001(J.Bestard-Escalas), M.D.Ledesma, M.Taniguchi, T.Okazaki, M.L.Martin, G.Barceló-Coblijn:Unraveling thespecific role of sphingomyelins in cell physiology: Where are we?, Sphingolipids: Biology, Synthesis and Functions(Angel Catalá), 91-128, America, 2015.

7200A002(H.Sawai), M.Taniguchi, T.Okazaki:Role of sphingolipids in hematological malignancies: Lymphoproliferative
disorders, Bioactive Sphingolipids in Cancer Biology and Therapy (Yusuf A. Hannun, Chiara Luberto, Cungui Mao,
Lina Marie Obeid), 23-51, Bundesrepublik Deutschland, 2015.

102

Publications
Originals
7200B001

T.Sakai, Y.Masaki, N.Otsuki, I.Sakamaki, S.Kishi, T.Miyazono, Y.Urasaki, J.Murakami, T.Satoh, T.Nakamura,
H.Iwao, A.Nakajima, T.Kawanami, M.Miki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, T.Ueda:Prospective
clinical study of R-CMD therapy for indolent B cell lymphoma and mantle cell lymphoma from the Hokuriku
Hematology Oncology Study Group, Medical Oncology, 32:232-238, 2015.

7200B002(H.Sawai), H.Ogiso, T.Okazaki:Differential changes in sphingolipids between TNF-induced necroptosis andapoptosis in U937 cells and necroptosis-resistant sublines, Leukemia Research, 39:964-970, 2015.

7200B003

Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.

7200B004(T.Suzuki), A.Yamamoto, M.Ohsawa, Y.Motoo, H.Mizukami, T.Makino:Ninjin'yoeito and ginseng extract prevent
oxaliplatin-induced neurodegeneration in PC12 cells, Journal of Natural Medicines, 69:4;531-537, 2015.

7200B005(M.Kuroda), M.Shimizu, N.Inoue, I.Ikeno, H.Nakagawa, A.Yokoi, Y.Niida, M.Konishi, H.Kaneda, N.Igarashi,
J.Yamahana, H.Taneichi, H.Kanegane, M.Ito, S.Saito, K.Furuichi, T.Wada, M.Nakagawa, H.Yokoyama,
A.Yachie:Serum tau protein as a marker of disease activity in enterohemorrhagic Escherichia coli O111-induced
hemolytic uremic syndrome, Neurochemistry International, 85-86:24-30, 2015.

7200B006(S.Y.Kong), M.Takeuchi, H.Hyogo, G.McKeown-Eyssen, S.Yamagishi, K.Chayama, P.J.O'Brien, P.Ferrari,
K.Overvad, A.Olsen, A.Tjonneland, M.Boutron-Ruault, N.Bastide, F.Carbonnel, T.Kuehn, R.Kaaks, H.Boeing,
K.Aleksandrova, A.Trichopoulou, P.Lagiou, E.Vasilopoulou, G.Masala, V.Pala, M.D.Magistris, R.Tumino,
A.Naccarati, H.B.Bueno-De-Mesquita, P.H.Peeters, E.Weiderpass, J.R.Quiros, P.Jakszyn, M.Sanchez,
M.Dorronsoro, D.Gavrila, E.Ardanaz, M.Rutegard, H.Nystroem, N.Wareham, K.Khaw, K.Bradbury, I.Romieu,
H.Freisling, F.Stavropoulou, M.J.Gunter, A.J.Cross, E.Riboli, M.Jenab, W.R.Bruce:The association between
glyceraldehyde-derived advanced glycation end-products and colorectal cancer risk, Cancer Epidemiology
Biomarkers & Prevention, 24:12;1855-1863, 2015.

7200B007(M.Kajikawa), A.Nakashima, N.Fujimura, T.Maruhashi, Y.Iwamoto, A.Iwamoto, T.Matsumoto, N.Oda, T.Hidaka,
Y.Kihara, K.Chayama, C.Goto, Y.Aibara, K.Noma, M.Takeuchi, T.Matsui, S.Yamagishi, Y.Higashi:Ratio of serum
levels of AGEs to soluble form of RAGE is a predictor of endothelial function, Diabetes Care, 38:1;119-125, 2015.

7200B008(K.Fukami), S.Yamagishi, K.Sakai, Y.Kaida, M.Yokoro, S.Ueda, Y.Wada, M.Takeuchi, M.Shimizu, H.Yamazaki,
S.Okuda:Oral L-Carnitine Supplementation Increases Trimethylamine-N-oxide but Reduces Markers of Vascular
Injury in Hemodialysis Patients, Journal of Cardiovascular Pharmacology, 65:3;289-295, 2015.

7200B009(J.Takino), K.Nagamine, M.Takeuchi, T.Hori:In vitro identification of nonalcoholic fatty liver disease-related
protein hnRNPM, World Journal of Gastroenterology, 21:6;1784-1793, 2015.

7200B010(Y.Koriyama), A.Furukawa, M.Muramatsu, J.Takino, M.Takeuchi:Glyceraldehyde caused Alzheimer's disease-likealterations in diagnostic marker levels in SH-SY5Y human neuroblastoma cells, Scientific Reports, 5:1-7, 2015.

7200B011(H.Kan), S.Yamagishi, A.Ojima, K.Fukami, S.Ueda, M.Takeuchi, H.Hyogo, H.Akita, K.Chayama:Elevation ofserum levels of advanced glycation end products in patients with non-B or non-C hepatocellular carcinoma,
Journal of Clinical Laboratory Analysis, 29:6;480-484, 2015.

7200B012(N.Tahara), S.Yamagishi, N.Kodama, A.Tahara, A.Honda, Y.Nitta, S.Igata, T.Matsui, M.Takeuchi, H.Kaida,
S.Kurata, T.Abe, Y.Fukumoto:Clinical and biochemical factors associated with area and metabolic activity in thevisceral and subcutaneous adipose tissues by FDG-PET/CT, Journal of Clinical Endocrinology & Metabolism,
100:5;E739-E747, 2015.

7200B013

M.Takeuchi, J.Takino, H.Shirai, M.Kawakami, S.Furuno, Y.Kobayashi:Assessment of total sugar and glucose
concentrations in commonly consumed beverages in Japan, Nutrition and Food Technology:Open Access, 1:2;1-9,
2015.

7200B014

M.Takeuchi, J.Takino, S.Furuno, H.Shirai, M.Kawakami, M.Muramatsu, Y.Kobayashi, S.Yamagishi:Assessment of
the concentrations of various advanced glycation end-products in beverages and foods that are commonly
consumed in Japan, PLoS One, 10:3;e0118652, 2015.

103

7200B015(M.Takeda), T.Ohnuma, M.Takeuchi, N.Katsuta, H.Maeshima, Y.Takebayashi, M.Higa, T.Nakamura, S.Nishimon,
T.Sannohe, Y.Hotta, R.Hanzawa, R.Higashiyama, N.Shibata, T.Gohda, Y.Suzuki, S.Yamagishi, Y.Tomino,
H.Arai:Altered serum glyceraldehyde-derived advanced glycation end product (AGE) and soluble AGE receptor
levels indicate carbonyl stress in patients with schizophrenia, Neuroscience Letters, 593:51-55, 2015.

7200B016

M.Taniguchi, H.Ogiso, T.Takeuchi, K.Kitatani, H.Umehara, T.Okazaki:Lysososomal ceramide generated by acidsphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein innatural killer/T lymphoma cell apoptosis, Cell Death and Disease, 6:e1717;1-12, 2015.

7200B017(H.Yazama), K.Kitatani, K.Fujiwara, M.Kato, M.Hashimoto-Nishimura, K.Kawamoto, K.Hasegawa, H.Kitano,
A.Beilawska, J.Bielawski, T.Okazaki:Dietary glucosylceramides suppress tumor growth in a mouse xenograft modelof head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide,International Journal Clinical Oncology, 20:3;438-446, 2015.

7200B018(A.Okumura), M.Ozaki, Y.Niida:Development of a practical NF1 genetic testing method through the pilot analysis
of five Japanese families with neurofibromatosis type 1., Brain & Development, 37:7;677-689, 2015.

7200B019

H.Ogiso, M.Taniguchi, T.Okazaki:Analysis of lipid-composition changes in plasma membrane microdomains,
Journal of Lipid Research, 56:8;1594-1605, 2015.

7200B020

Y.Nakazawa, S.Kuwasaki, S.Inoue, D.Nakai, N.Morita, H.Tachibana, I.Chikazawa, T.Tanaka, Y.Motoo,
K.Miyazawa:Initial experience of enzalutamide in patients with castration resisitant prostate cancer, Journal of
Kanazawa Medical University, 40:2・3;196-200, 2015.

Reviews
7200C001

Y.Niida:Development and Clinical Application of Mutation Screening Method “CHIPS”, Journal of Kanazawa
Medical University, 40:2・3;84-91, 2015.

7200C002

M.Takeuchi, J.Takino, A.Sakasai-Sakai, T.Takata, T.Ueda :Involvement of toxic AGEs(TAGE) in theonset/deterioration of lifestyle-related diseases -New preventive strategy-:-Toxic truth about dietary AGEs andsugars-, Journal of Kanazawa Medical University, 40:95-103, 2015.

7200C003

Y.Motoo:Gender difference in clinical practice for cancer patients, Japanese Journal of Clinical Medicine,
73:4;666-670, 2015.

7200C004(K.Kitatani), M.Taniguchi, T.Okazaki:Role of sphingolipids and metabolizing enzymes in hematologicalmalignancies, Molecules and Cells, 38:6;482-495, 2015.

7200C005

M.Takeuchi, A.Sakasai-Sakai, J.Takino, T.Takata, T.Ueda, M.Tsutsumi:Toxic AGEs (TAGE) theory in thepathogenesis of NAFLD and ALD, International Journal of Diabetes and Clinical Researsh, 2:4;1-5, 2015.

7200C006(J.Takino), K.Nagamine, T.Hori, A.Sakasai-Sakai, M.Takeuchi:Contribution of the toxic advanced glycation endproducts-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma, World Journal of
Hepatology, 7:23;2459-2469, 2015.

Case Reports
7200D001(N.Hatta), A.Takata, S.Ishizawa, Y.Niida:Family with MSH2 mutation presenting with keratoacanthoma andprecancerous skin lesions, Journal of Dermatology, 42:11;1087-1090, 2015.

7200D002

J.Moriya, J.Yamakawa, K.Takeuchi, Y.Motoo, J.Kobayashi:Effective treatment with Kampo medicines offibromyalgia that occurred after the mycoplasma infection, PAIN AND KAMPO MEDICINE, 25:129-133, 2015.

7200D003

Y.Niida, M.Ozaki, E.Takase, T.Yokoyama, S.Yamada:A girl with greig cephalopolysyndactyly contiguous genedeletion syndrome: The importance and usefulness of DNA microarray analysis, Hereditary Genetics, S7:1-3, 2015.

7200D004

Y.Niida:Radiological diagnosis of a neonate with mucolipidosis II (I-cell disease), Clinical Medical Image Library,
1:2;17-18, 2015.

104

Short Communications
7200E001

M.Takeuchi, A.Sakasai-Sakai, T.Takata, T.Ueda, J.Takino, M.Tsutsumi, H.Hyogo, S.Yamagishi:Serum levels of
toxic AGEs (TAGE) may be a promising novel biomarker in development and progression of NASH., Medical
Hypotheses, 84:490-493, 2015.

7200E002

Y.Niida, O.Ozaki, M.Inoue, E.Takase, M.Kuroda, Y.Mitani, A.Okumura, A.Yokoi, S.Fujita, K.Yamada:CHIPS for
genetic testing to improve a regional clinical genetic service, Clinical Genetics, 88:2;155-160, 2015.

7200E003

Y.Niida:How do you analyze a mutation of the gene consisting of one hundred exons?, Advanced Techniques in
Biology & Medicine, 3:3;138, 2015.

7200E004

Y.Niida:CHIPS to disseminate the genetic testing of rare diseases, Gene Technology, 4:3;127-127, 2015.

7200E005

Y.Niida:Finding gene mutations by the enzyme: Chips for a simple and highly sensitive enzyme mismatch cleavage
method, Enzyme Engineering, 4:2;131, 2015.

7200E006

Y.Niida:CHIPS for a mutation screening of a large sized gene: An example of NF2 analysis, Pharmaceutia Analytica
Acta, 6:11;440, 2015.

Others
7200F001

A.Sakasai-Sakai, M.Jinno, M.Takeuchi:Usefulness of toxic AGEs (TAGE) as a biomarker for fertility treatment,
Meeting of the Japan Mibyou System Association, 21:1;93, 2015.

7200F002

Y.Motoo:Description of Kampo medicines in the clinical practice guidelines for irritable bowel syndrome, Journal of
Gastroenterology, 50:7;816, 2015.

7200F003

M.Takauchim, J.Takino, S.Furuno, H.Shirai, M.Kawakami, M.Muramatsu, Y.Kobayashi:Pitfalls regarding today's
eating habits;Truth about AGEs in foods and drinks and their glucotoxicity, Meeting of the Japan Mibyou System
Association, 22:130, 2015.

Presentations at Conference
International Conference (Key Note Lecture)
7200G001

T.Okazaki:Role of membrane lipids, sphingomyelin and ceramide in tumor cell growthi, migration and death.,
Cancer science institute of singapore, Singapore, 2015.

International Conference (Synposium)
7200H001

Y.Motoo:Evidence Reports on Kampo Treatment (EKAT) and Kampo medicines in clinical practice guidelines(KCPG), The 10th International Congress of Complementary Medicine Research - ICCMR 2015, Jeju, 2015.

7200H002

Y.Motoo,I.Arai,K.Tsutani:Systematic review on the use of Kampo diagnosis in randomized controlled trials of
Kampo medicines, 3rd International Symposium for Japanese Kampo Medicine (ISJKM), Vienna, 2015.

International Conference (Presentations)
7200I001

T.Okazaki, L.O.Waedhani, M.Hashimoto, K.Kitatani, H.Ogiso, Y.Ueda, M.Taniguchi:Enhancement of infiltration ofmalignant lymphoma cells in the mouse liver by sphingomyelin deficiency through sphingomyelin synthase2 (SMS2),
56th International Conference on the Bioscience of lipids, Puerto Iguzu, 2015.

105

7310

Division of Innovative Research

Title

Name

Field of Specialization

Professor(Additional Post)

YONEKURA Hideto

Molecular mechanisms of angiogenesis, Alternative mRNA processing

Associate
Professor(Additional Post)NISHIJO Muneko

Environmental epidemiology, Enviromental health sciences,
Epidemiology of cadmium pollution

Faculty

Keywords of Research
Epidemiology of health effects of environmental cadmium exposure, dioxins, Toxicology of environmental pollutants,
neurovirology, Cancer chemoprevention by natural products,

Outline of Research
1. Epidemiology of health effects of environmental cadmium exposure, and dioxins., Toxicology of environmental pollutants.
2. Cellular and molecular mechanisms in angiogenesis

Publications
Originals
7310B001

E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura,
T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.

7310B002

PT.Tai, M.Nishijo, NTN.Anh, TN.Nghi, HV.Luong, TH.Anh, VT.Nguyen, H.Nishijo:Perinatal dioxin exposure andthe neurodevelopment of Vietnamese toddlers at 1 year of age, Science of the Total Environment, 536:575-581,
2015.

7310B003

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido,
H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal
dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.

7310B004(K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice forrenal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.

7310B005(HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo,
H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinateddibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.

7310B006

TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa,T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.

7310B007

S.Ueda, T.Ichiseki, Y.Yoshitomi, H.Yonekura, Y.Ueda, A.Kaneuji, T.Matsumoto:Osteocytic cell necrosis is caused
by a combination of glucocorticoid-induced Dickkopf-1 and hypoxia, Medical Molecular Morphology, 48:2;69-75,
2015.

106

7310B008

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

7310B009(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular
dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.

7310B010(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause
mortality increased by environmental cadmium exposure in the Japanese general population in cadmium nonpolluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.

Reviews
7310C001(C.Chen),P.Xun, M.Nishijo, A.Sekikawa, K.He:Cadmium exposure and risk of pancreatic cancer: a meta-analysis ofprospective cohort studies and case-control studies among individuals without occupational exposure history,
Environmental Science and Pollution Research, 22:22;17465-17474, 2015.

Presentations at Conference
International Conference (Synposium)
7310H001

M.Nishijo:History of Cd pollution and health effect., A Symposium on Health Effects among Cadmium Exposed
Inhabitants in Mae Sot District,Tak Province,Thailand, Mae Sot Thailand, 2015.

7310H002

M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in theCadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.

International Conference (Presentations)
7310I001(TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H.
Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian
Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.

7310I002

TN.Nghi, PT.Tai, PN.Thao, M.Nishijo:Dioxin concentration in breast milk and umbilical cord blood samples ofmother-baby pairs living near Bien Hoa Airport., International workshop on the harmful effects of Agent
Orange/Dioxin on the environment and human health of Vientnam, Hanoi, 2015.

7310I003

M.Nishijo,TN.Nghi,PN.Thao,PT.Tai,AH.Tran,HV.Luong,H.Nishijo:Dioxin effects on groeth and neurodevelopmentof infants and children in Vietnam., International workshop on the harmful effects of Agent Orange/Dioxin on theenvironment and human health of Vietnam, Hanoi, 2015.

7310I004

H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.

107

7320

Division of Vision Research for Environmental HealthFaculty
Title

Name

Field of Specialization

Professor(Additional Post)

SASAKI Hiroshi

cataract, epidemiology, uveitis

Professor(Additional Post)

KOJIMA Masami

cataract, ophthalmological optics, electromagnetic ocular injury,
epidemiolgy

Assistant
Professor(Additional Post)

HATSUSAKA Natsuko ophthalmological optics

Keywords of Research
electromagnetic waves, ultraviolet rays, radioactive rays, cataract, pterygium, pinguecula.

Outline of ResearchThis research division studies environmental effects on incidence of ocular diseases. In quantitative studies of radio
frequency (RF) electromagnetic spectrum effects on eyes, ocular effects from exposure to wavelengths encountered in daily
life are examined by experimentation on rabbit eyes. Research on ocular exposure to ultraviolet (UV) wavelengths utilizes ahuman like mannequin equipped with UV sensors, and evaluates the efficacy of sunglasses, eye glasses and otheraccessories in offering eye protection against harmful exposure.
Our longitudinal epidemiological studies on eyes in Japan (Ishikawa) and Iceland, epidemiological surveys on blindness and
UV-related eye disease in Tanzania, and ocular epidemiological studies in domestic and international regions with different
climate conditions were conducted to investigate and analyze associations among ocular UV exposure and cataract,pterygium, and pinguecula. In our epidemiological study on UV-related ocular diseases targeting Japanese and Taiwanesechildren, the effects of ocular UV exposure in childhood are examined.
In 2013, a longitudinal study on radiation exposure dose and incidence of lens opacity in emergency workers of TEPCO
Fukushima Daiichi Nuclear Power Plant was commenced and is envisaged to include approximately 20,000 subjects.

Publications
Originals
7320B001

M.Fukuda, H.Sasaki:The transcorneal penetration of commercial ophthalmic formulations containing timolol
maleate in rabbit eyes, Journal of Ocular Pharmacology and Therapeutics, 31:1;57-60, 2015.

7320B002(H.Maeda), T.Takata, N.Fujii, H.Sakaue, S.Nirasawa, S.Takahashi, H.Sasaki, N.Fujii:Rapid survey of four asp
isomers in disease-related proteins by LC-MS combined with commercial enzymes, Analytical Chemistry, 87:561568, 2015.

7320B003

M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki:Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40
GHz), Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.

7320B004

S.Enta, N.Hatsusaka, Y.Sakamoto, N.Mita, M.Takahashi, H.Osada, E.Kubo, H.Sasaki:Visual acuity and contrast
visual acuity predicted from cataract type, The Journal of the Japanese Society for Cataract Research, 27:68-73,
2015.

180B005(K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property
measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.

7320B006

M.Fukuda, H.Sasak:Effects of fluoroquinolone-based antibacterial ophthalmic solutions on corneal wound healing,
Journal of Ocular Pharmacology and Therapeutics, 31:9;536-540, 2015.

108

7320B007

Y.Takahashi, T.Kawamorita, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, E.Kubo, H.Sasaki:Optical simulation forsubsurface nanoglistening, Journal of Cataract and Refractive Surgery, 41:193-198, 2015.

Reviews
7320C001(K.Minami), K.Miyata, N.Nagai, H.Sasaki:Use of a warmed ophthalmic viscoelastic device to accelerate theunfolding of 1-piece intraocular lenses in the capsular bag, Journal of Cataract & Refractive surgery, 41:23322333, 2015.

7320C002(Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.

7320C003

H.Sasaki:Update no multifocal intraocular lenses' development, Journal of Japanese Ophthalmological Society,
119:1;3-5, 2015.

Presentations at Conference
International Conference (Presentations)
7320I001

H.Sasaki:Standardized classifications and severity scales of cataract , Asia Arvo, Yokohama, 2015.

7320I002(Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe,
M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with manycore architecture based computing, URSI AT-RASC, Canary Istands, 2015.

7320I003

H.Sasaki, E.Shibuya, M.Takahashi, A.Okamoto, N.Mita, N.Hatsusaka, S.Shibata, T.Shibata, K.Sasaki,
E.Kubo:Effect of forward light scattering on visual function in eyes with cortical cataract, Association for Researchin Vision and Ophthalology, Denver, 2015.

7320I004

T.Shibata, S.Shibata, N.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh, E.Kubo:FGF-2 regression of the tropomyosin
expression through MAPK/ERK kinase pathway in lens epithelial cells, Association for Research in Vision andOphthalology, Denver, 2015.

7320I005

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expression profiling of lensepithelial cells in a rat posterior capsular opacity model in vivo, Association for Research in Vision andOphthalology, Denver, 2015.

7320I006

Y.Seki, T.Shibata, Y.Yabata, M.Sasaki, H.Osada, T.Saruta, H.Asano, E.Kubo, A.Sanyiwa, H.Sasaki:Prevalence of
pinguecula in children living in rural Tanzania, Association for Research in Vision and Ophthalology, Denver, 2015.

7320I007

H.Sasaki, E.Shibuya, M.Takahashi, N.Shibata, Y.Takahashi, S.Shibata, T.Shibata, N.Mita, E.Kubo:Effect of forward
light scattering on visual function in eyes with retrodots, XXXIII Congress of the RSCRS, Barcelona, 2015.

7320I008(Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal
dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,First PEM International Workshop in Kyoto, Kyoto, 2015.

7320I009

E.Kubo, S.Shibata, N.Shibata, T.Shibata, E.Kiyokawa, H.Sasaki, DP.Singh:Gene expressin profiling of lensepithelial cells in posterior capsular opacity and the role of decorin, The 3rd International Conference on the Lens
2015, Kona, 2015.

7320I010

N.Mita, M.Sasaki, Y.Takahashi, Y.Seki, A.Okamoto, T.Shibata, S.Shibata, E.Kubo, H.Sasaki:Higher-orderaberrations in Japanese eyes with cataract and eyes with aspherical intraocular lenses, The 3rd International
Conference on the Lens 2015, Kona, 2015.

7320I011

S.Shibata, N.Shibata, T.Shibata, N.Tanimura, H.Sasaki, E.Kubo:Human age related cataract and decorin:correlations among opacity severity, age and decorin expression, The 3rd International Conference on the Lens
2015, Kona, 2015.

7320I012

H.Osada, Y.Yoshitomi, T.Ikeda, Y.Yoshitake, H.Yonekura, E.Kubo, H.Sasaki:Identification of UVB responsive
genes in invivo mouse lens by cDNA microarray, The 3rd International Conference on the Lens 2015, Kona, 2015.

109

7320I013

E.Shibuya, N.Mita, N.Hatsusaka, S.Shibata, N.Shibata, T.Shibata, E.Kubo, H.Sasaki:Influence on visual function by
high-order aberration, forward and backward light scattering in eyes with nuclear opacity, The 3rd International
Conference on the Lens 2015, Kona, 2015.

7320I014

N.Hatsusaka, H.Osada, E.Shibuya, A.Okamoto, M.Sasaki, M.Takahashi, A.Nakano, Y.Seki, E.Kubo,
H.Sasaki:Lenticular findings in emergency workers at Tokyo Electric Power Fukushima Nuclear Power Plant at 4
years post-exposure, The 3rd International Conference on the Lens 2015, Kona, 2015.

7320I015

H.Sasaki, H.Asano, T.Hiraoka, H.Osada, T.Shibata, M.Sasaki, Y.Seki, T.Saruta, F.Fujikake, Y.Tabata, T.Oshika,
A.Sanyiwa:Mopia and related factors in Tanzanian adults, The 3rd International Conference on the Lens 2015,
Kona, 2015.

7320I016

T.Shibata, S.Shibata, H.Sasaki, DP.Singh, E.Kiyokawa, M.Ikawa, E.Kubo:Suppression of injury-induced epithelialmesenchymal transition in tropomyosin 2 mutant mouse lenses created by CRISPR-CAS9, The 3rd International
Conference on the Lens 2015, Kona, 2015.

110

7340

Division of Anticipatory Molecular Food Science and Technology

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

KOYA Daisuke

diabetes, hypertension, obesity, aging

KANASAKI Keizo

diabetes, hypertenstion, obesity, preeclampsia

KITADA Munehiro

diabetes, diabetical renal disease, hypertension

Associate
Professor(Additional Post)
Associate
Professor(Additional Post)

Publications
Originals
7340B001(M.Yasuda-Yamahara), S.Kume, K.Yamahara, J.Nakazawa, M.Chin-Kanasaki, H.Araki, S.Araki, D.Koya,
M.Haneda, S.Ugi, H.Maegawa, T.Uzu:Lamp-2 deficiency prevents high-fat diet-induced obese diabetes via
enhancing energy expenditure, Biochemical and Biophysical Research Communications, 465:2;249-255, 2015.

7340B002

S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of
DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.

7340B003(S.Araki), M.Haneda, D.Koya, K.Kondo, S.Tanaka, H.Arima, S.Kume, J.Nakazawa, M.Chin-Kanasaki, S.Ugi,
H.Kawai, H.Arai, T.Uzu, H.Maegawa:Urinary potassium excretion and renal and cardiovascular complications inpatients with type 2 diabetes and normal renal function, Clinical journal of the American Society of Nephrology :CJASN., 10:12;2152-2158, 2015.

7340B004(S.Kato), S.Maruyama, H.Makino, J.Wada, D.Ogawa, T.Uzu, H.Araki, D.Koya, K.Kanasaki, Y.Oiso, M.Goto,
A.Nishiyama, H.Kobori, E.Imai, M.Ando, S.Matsuo:Anti-albuminuric effects of spironolactone in patients with type2 diabetic nephropathy: a multicenter, randomized clinical trial, Clinical and Experimental Nephrology, 19:6;10981106, 2015.

7340B005(Y.Tanaka), S.Kume, H.Araki, J.Nakazawa, M.Chin-Kanasaki, S.Araki, F.Nakagawa, D.Koya, M.Haneda,
H.Maegawa, T.Uzu:1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney
proximal tubular cell, Free Radical Biology & Medicine., 89:831-841, 2015.

Reviews
7340C001

T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.

7340C002(M.Haneda), K.Utsunomiya, D.Koya, T.Babazono, T.Moriya, H.Makino, K.Kimura, Y.Suzuki, T.Wada, S.Ogawa,
M.Inaba, Y.Kanno, T.Shigematsu, I.Masakane, K.Tsuchiya, K.Honda, K.Ichikawa, K.Shide:A new classification ofdiabetic nephropathy 2014: a report from joint committee on diabetic nephropathy, Journal of Diabetes
Investigation, 6:2;242-246, 2015.

7340C003

N.Ueki, S.Takeda, D.Koya, K.Kanasaki:The relevance of the renin-angiotensin system in the development of drugs
to combat preeclampsia, International Journal of Endocrinology [Electronic Resource], 2015:572713;1-12, 2015.

7340C004

Kidney fibrosis and endothelial injury, The japanese journal of Nephrology, 57:7;1200-1205, 2015.

7340C005

K.Nitta, M.kanasaki, K.Kanasaki, D.koya:The role of angiotensin-converting enzyme inhibition to cimbat kidney
fibrosis, Journal of Kanazawa Medical University, 40:2・3;131-138, 2015.

7340C006

Diagnosis and management of diabetic nephropathy, Nihon Rinsyo, 73:12;2037-2043, 2015.

111

7340C007(S.Kume), D.Koya:Autophagy: A novel therapeutic target for diabetic nephropathy, Diabetes & Metabolism
Journal., 39:3;451-460, 2015.

Case Reports
7340D001

Y.Sasagawa, O.Tachibana, A.Nakagawa, D.Koya, H.Iizuka:Pituitary apoplexy following gonadotropin-releasing
hormone agonist administration with gonadotropin-secreting pituitary adenoma, Journal of Clinical Neuroscience,
22:3;601-603, 2015.

Short Communications
7340E001

D.Koya:Epidermal growth factor receptor signaling and the progression of diabetic nephropathy, Journal of
Diabetes Investigation, 6:5;519-521, 2015.

Presentations at Conference
International Conference (Synposium)
7340H001

D.Koya:S21 Diabetic complications The role of autophagy in diabetic nephropathy, The Korean Society for
Biochemistry and Molecular Biology International Conference 2015, Seoul, 2015.

7340H002

D.Koya:Symposium12 Diverse cell signaling in metabolic syndrome High fat diet-induced hepatosteatosis wasameliorated by the treatment with ketogeic amino acid, 2015 International Congress on Obesity and Metabolic
Syndrome in conjunction with the 43rd Annual Scientific Meeting of KSSO, Seoul, 2015.

International Conference (Presentations)
7340I001

K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling
responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, 2015.

7340I002

K.Kanasaki, S.Shi, M.Kanasaki, D.Koya:The interaction between DPP-4 and intergrin β1 regulates the signaling
responsible for induction of the endothelial to mesenchymal transition in diabetic kidney, American Diabetes
Association 74th Scientific Sessions, Boston, MA, USA, 2015.

112

7350

Division of Systems Bioscience for Drug Discovery Based on Intrinsically
Disordered Proteins

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)TOMOSUGI Naohisa

Clinical Proteomics

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Associate
Professor(Additional Post)SHIMASAKI Takeo

Medical Oncology, Gastroenterology, Bioinformatics

Books
7350A001

T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus
Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.

Publications
Originals
7350B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.

7350B002

J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.

7350B003

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.

7350B004

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7350B005

J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic
fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.

7350B006

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7350B007

F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial
learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.

7350B008

Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to
cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.

113

Reviews
7350C001(K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.

7350C002

Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.

Short Communications
7350E001(H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the
mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.

Presentations at Conference
International Conference (Presentations)
7350I001

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

114

7400

Research Support Center

Faculty
Title

Name

Field of Specialization

Professor(Additional Post)

ISHIGAKI Yasuhito

Molecular and Cellular Biology

Professor(Additional Post)

NAKAGAWA Hideaki

Epidemiology of cardiovascular diseases, occupational medicine,preventive medicine

Professor(Additional Post)

NAKAMURA Akira

Immunology

Senior AssistantProfessor(Additional Post)

MURAKAMI Manabu

Pathogenicity of flavivirus isolated from the field-collectedmosquitoes

Books
7400A001

T.Takegami, T.Tasaki, M.Murakami, Y.Ishigaki, M.Taniguchi, T.Nojima, S.Nukuzuma:Japanese Encephalitis Virus
Infection and Replication: Biological Roles of Nonstructural Protein NS4a and The 3'-Untranslated Region in
Persistent Infection, Japanese Encephalitis, 1-17, SMGroup (USA), USA, 2015.

Publications
Originals
7400B001

Y.Ishigaki, Y.Nakamura, T.Tatsuno, S.Ma, N.Tomosugi:Phosphorylation status of human RNA-binding protein 8A
in cells and its inhibitory regulation by Magoh, Experimental Biology and Medicine, 240:4;438-445, 2015.

7400B002

J.Zhang, Y.Ishigaki, T.Takegami:Hepatitis C virus NS3 protein modulates the biological behaviors of malignant
hepatocytes by altering the expression of host cell microRNA, Molecular Medicine Reports, 12:4;5109-5115, 2015.

7400B003

K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.

7400B004(D.Sugiyama), T.Okamura, M.Watanabe, A.Higashiyama, N.Okuda, Y.Nakamura, A.Hozawa, Y.Kita, A.Kadota,
Y.Murakami, N.Miyamatsu, T.Ohkubo, T.Hayakawa, Y.Miyamoto, K.Miura, A.Okayama, H.Ueshima; NIPPONDATA 80/90 Research Group.:Risk of hypercholesterolemia for cardiovascular disease and the population
attributable fraction in a 25-year Japanese cohort study, Journal of Atherosclerosis and Thrombosis, 22:1;95-107,
2015.

7400B005

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido,
H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal
dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.

7400B006(K.Nogawa), T.Kido, M.Nishijo, H.Nakagawa, Y.Suwazono:Benchmark dose of cadmium concentration in rice forrenal effects in a cadmium-polluted area in Japan, Journal of Applied Toxicology, 35:1;24-28, 2015.

7400B007

Y.Tachi, T.Okuda, N.Kawahara, N.Kato, Y.Ishigaki, T.Matsumoto:Expression of hyaluronidase-4 in a rat spinal
cord hemisection model, Asian Spine Journal, 9:1;7-13, 2015.

7400B008(M.Satoh), T.Ohkubo, K.Asayama, Y.Murakami, M.Sakurai, H.Nakagawa, H.Iso, A.Okayama, K.Miura, Y.Imai,
H.Ueshima, T.Okamura; Evidence for Cardiovascular Prevention From Observational Cohorts in Japan(EPOCH?JAPAN) Research Group:Combined effect of blood pressure and total cholesterol levels on long-termrisks of subtypes of cardiovascular death: Evidence for cardiovascular prevention from observational cohorts inJapan., Hypertension, 65:3;517-524, 2015.

7400B009(T.Hisamatsu), K.Miura, A.Fujiyoshi, T.Okamura, T.Ohkubo, SY.Nagasawa, M.Horie, A.Okayama, H.Ueshima;
NIPPON DATA80 Research Group:Long-term outcomes associated with prolonged PR interval in the general
Japanese population, International Journal of Cardiology, 184:291-293, 2015.

115

7400B010(HD.Manh), T.Kido, PT.Tai, R.Okamoto, S.Honma, SX.Liang, LT.Anh, S.Maruzeni, TN.Nghi, M.Nishijo,
H.Nakagawa, DD.Nhu, DV.Tung, NN.Hung, LK.Son:Levels of polychlorinated dibenzodioxins and polychlorinateddibenzofurans in breast milk samples from three dioxin-contaminated hotspots of Vietnam, Science of The Total
Environment, 511:416-422, 2015.

7400B011(N.Okuda), K.Miura, A.Okayama, T.Okamura, RD.Abbott, N.Nishi, A.Fujiyoshi, Y.Kita, Y.Nakamura, N.Miyagawa,
T.Hayakawa, T.Ohkubo, Y.Kiyohara , H.Ueshima; NIPPON DATA80 Research Group.:Fruit and vegetable intake
and mortality from cardiovascular disease in Japan: a 24-year follow-up of the NIPPON DATA80 Study., European
Journal of Clinical Nutrition, 69:4;482-488, 2015.

7400B012

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7400B013

J.Moriya, Q.He, H.Uenishi, S.Akazawa, J.Yamakawa, J.Kobayashi, Y.Ishigaki:Induction murine models of chronic
fatigue syndrome by brucella abortus antigen injections: is anemia induced or not?, Biomed Research International,
2015:191489, 2015.

7400B014

A.Nakajima, Y.Masaki, T.Nakamura, T.Kanawami, Y.Ishigaki, T.Takegami, M.Kawano, K.Yamada, N.Tsukamoto,
S.Matsui, T.Saeki, K.Okazaki, T.Kamisawa, T.Miyashita, Y.Yakushijin, K.Fujikawa, M.Yamamoto, H.Hamano,
T.Origuchi, S.Hirata, H.Tsuboi, T.Sumida, H.Morimoto, T.Sato, H.Iwao, M.Miki, T.Sakai, Y.Fujita, M.Tanaka,
T.Fukushima, T.Okazaki, H.Umehara:Decreased expression of innate immunity-related genes in peripheral bloodmononuclear cells from patients with IgG4-related disease, PLoS One, 10:5;e0126582, 2015.

7400B015(A.Misawa), K.Yoshita, T.Fukumura, T.Tanaka, J.Tamaki, T.Takebayashi, Y.Kusaka, H.Nakagawa, H.Yamato,
A.Okayama, K.Miura, T.Okamura, H.Ueshima, HIPOP-OHP Research Group:Effects of long-term intervention ina work cafeteria on employee vegetable intake, Journal of occupational health, 57:3;97-107, 2015.

7400B016

TN.Nghi, M.Nishijo, HD.Manh, PT.Tai, HV.Luong, TH.Anh, PN.Thao, NV.Trung, T.Waseda, H.Nakagawa,T.Kido, H.Nishijo:Dioxins and Nonortho PCBs in Breast Milk of Vietnamese Mothers Living in the Largest Hot
Spot of Dioxin Contamination, Environmental Science & Technology, 49:9;5732-5742, 2015.

7400B017

F.Wang, Y.Zhang, L.Wang, P.Sun, X.Luo, Y.Ishigaki, T.Sugai, R.Yamamoto, N.Kato:Improvement of spatial
learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic
stimulation in Alzheimer's disease model mice, Neuropharmacology, 97:210-219, 2015.

7400B018

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

7400B019(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular
dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.

7400B020(IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination forsurvival data, Biometrical Journal, 57:4;592-613, 2015.

7400B021(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause
mortality increased by environmental cadmium exposure in the Japanese general population in cadmium nonpolluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.

7400B022

Y.Li, K.Tanaka, L.Wang, Y.Ishigaki, N.Kato:Induction of memory deficit in mice with chronic exposure to
cerebrospinal fluid from patients with Anti-N-Methyl-D-Aspartate receptor encephalitis, The Tohoku Journal of
Experimental Medicine, 237:4;329-338, 2015.

7400B023(K.Nakamura), H.Nakagawa, Y.Murakami, A.Kitamura, M.Kiyama, K.Sakata, I.Tsuji, K.Miura, H.Ueshima,
T.Okamura; EPOCH?JAPAN research group.:Smoking increases the risk of all-cause and cardiovascular mortality
in patients with chronic kidney disease, Kidney International., 88:5;1144-1152, 2015.

116

7400B024(M.Nagai), T.Ohkubo, Y.Murakami, N.Takashima, A.Kadota, N.Miyagawa, Y.Saito,N.Nishi, N.Okuda, Y.Kiyohara,
H.Nakagawa, Y.Nakamura, A.Fujiyoshi, RD.Abbott,T.Okamura, A.Okayama, H.Ueshima, K.Miura.:Secular trendsof the impact of overweight and obesity on hypertension in Japan, 1980-2011, Hypertension Research, 38:11;790795, 2015.

Reviews
7400C001(K.Tazaki), M.Nakano, T.Takehara, Y.Ishigaki, H.Nakagawa:Experimental analysis of plastic materials containing
radionuclides for decontamination viability, 69:2;99-108, 2015.

7400C002(K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.

7400C003

Y.Nakmaura, T.Tatsuno, Y.Ishigaki:Scanning electron microscopy observation with ionic liquid, Journal of
Kanazawa Medical University, 40:2,3;125-130, 2015.

Short Communications
7400E001(H.Yoshida), Y.Ishigaki, A.Takizawa, K.Moro, Y.Kishi, T.Takahashi, H.Matsui:Comparative genomics of the
mucoid and nonmucoid strains of streptococcus pyogenes, isolated from the same patient with streptococcal
meningitis, 3:2;e00221-15, 2015.

Presentations at Conference
International Conference (Synposium)
7400H001

M.Nishijo, H.Nakagawa:A Study on Life Prognosis of Itai-Itai Disease Patients and Residents Living in theCadmium-Polluted Jinzu River Basin in Toyama., 13th International Conference on the Biogeochemistry of Trace
Elements (ICOBTE 2015), Fukuoka, 2015.

International Conference (Presentations)
7400I001

SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.

7400I002

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido,
Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22ndInternational Symposium on Shiftwork and Working Time, Elsinore, 2015.

7400I003

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

7400I004

X.Xu, H.Yoshizaki, Y.Ishigaki, E.Kubo, E.Kiyokawa:Regulation of the lens epithelial cell morphology by Dock5,
The Second International Meeting for Epithelial Tubulology, Sapporo, 2015.

7400I005(TT.Pham),M.Nishijo,MT.Do,NT.Pham,VL.Hoang,HA.Tran,VL.Nguyen,NN.Tran,VK.Tran,TT.Dang,TL.Nguyen,H.
Nishijo,H.Nakagawa:Dioxin concentrations in blood and food consumption habits of a population living near Bian
Hoa airbase a "hot spot" of dioxin contamination in Vietnam., The 35th international Symposium on Halogenated
Persistent Organic pollutants-Dioxin 2015, San Paulo, 2015.

117

School of Nursing

8010

Fundamental Nursing

Faculty
Title

Name

Field of Specialization

Professor

SAKAI Keiko

Nursing history, Nursing skills

Professor

TAKIUTI Takako

Nursing history, Nursing skill

Associate Professor

MATSUI Yuko

Nursing skill

Senior Assistant Professor

SUGIMORI Chiyoko

Nursing skill

Assistant Professor

OKAYAMA Miki

Patient education for diabetes

Keywords of Researchfundamental nursing, nursing skills, nursing education, communication skills, skin care, wound care

Outline of Research
1. Verification of nursing skills
2. Study of nursing education

Publications
Originals
8010B001

A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient
urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.

Presentations at Conference
International Conference (Presentations)
8010I001

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in homenursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.

118

8085I004

M.Hasegawa:An Intervention of Depression and Suicidal Behavior Patients With Emotion Modulation
Therapy(EMT), ACMHN’s 41st International Mental Health Nursing Conference 2015, Brisbane, 2015.

119

8040

Maternity Nursing・Midwifery

Faculty
Title

Name

Field of Specialization

Professor

YANAGIHARA
MachikoMatenity Nursing，Midwifery

Senior Assistant Professor

BODA Hitomi

Matenity Nursing，Midwifery

Senior Assistant Professor

IWATANI Kumiko

Matenity Nursing，Midwifery

Assistant Professor

YAMAZAKI Chisato

Maternity Nursing

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care

Outline of Research
Mother-child relation, Nursing education, Education effect, Breastfeeding, Parenting stress, Mother's feeling in child care.

Publications
Originals
8040B001

K.Iwatani, Y.Kiyosuke, H.Mori:Background factors causing difficulty of raising children by first-time mothers thatpublic health nurses and midwines have sensed: a report by performing home visiting services for infants, Maternal
health, 56:2;383-390, 2015.

Presentations at Conference
International Conference (Presentations)
8040I001

K.Iwatani,C.Yamazaki,T.Tamura,K.Shimada:Teaching activities for safety management in midwifery training,
ICMAPRC, Yokohama, 2015.

120

8050

Pediatric Nursing

Faculty
Title

Name

Field of Specialization

Senior Assistant Professor

HASHI Shinobu

Single mother, asthma, child, belief, parenting stress

Assistant Professor

TERAI Takahiro

Prevention of Maltreatment, Family Nursing in Child＆Maternal
Health Care

Keywords of Researchschool children, health promotion, families with a young child, child with a developmental disorder, rating scale for family's
problem-solving ability, intervention program for families, maltreatment, abuse, assessment,

Outline of Research
1.Psychometric development of a rating scale for family’s problem-solving ability with a young child with a developmental
disorder (FPAYCDD)
2.Study of the efficacy of a support program for families with a young child with a developmental disorder
3.Study of the efficacy of Lifestyle-improvement Program among Elementary School Children
4.Study of the system for carrying out abuse prevention

Presentations at Conference
International Conference (Presentations)
8050I001

S.Hashi:Single Mothers who have Children with Asthma in Japan, The 6th International Conference on Community
Health Nursing Research, Seoul, 2015.

121

8060

Adult Nursing

Faculty
Title

Name

Field of Specialization

Professor

KONYA Chizuko

Wound Care, Stoma care, Continence care

Associate Professor

MURAKADO Naoko

Chronic nursing，Diabetes nursing

Senior Assistant Professor

KINOSHITA Sachiko

Wound Care, Stoma care, Continence care

Senior Assistant Professor

KITAMURA Yoshiko

Cancer Nursing

Assistant Professor

ASANO Kimi

Wound Care

Assistant Professor

Natsuko Yamada

Critical Care

Keywords of Research
Wound care, Stoma care, Continence care, Cronic Disease Nursing, Cancer Nursing, Terminal Care

Outline of Research
Clinical Medical-Surgical Nursing.

Publications
Originals
8060B001

Y.Miyawaki, Y.Shimizu, K.Uchiumi, K.Asou, N.Murakado, K.Kuroda, H.Masaki, M.Seto, H.Ishii:Reliability andValidity of a Shortened Version of an Instrument for Diabetes Self-Care Agency, Journal of Nursing Measurement,
23:2;326-335, 2015.

8060B002

A.Kumagai, M.Heinai, Y.Matsui, C.Konya, K.Shimada, S.Kawakami, J.Sugama:Effectiveness of highly resilient
urethane foam mattresses in pressure ulcerprevention for special operative positions, Japanese journal of pressure
ulcer, 17:1;1-9, 2015.

8060B003

C.Konya, J.Sugama, H.Alozuki, H.Sanada:Effectiveness of a non-invasive pressure ulcer undermining measuring
device, 2:2;99-106, 2015.

8060B004(K.Mukai), E.Komatsu, T.Urai, Y.Nakajima, K.Asano, N.Ozaki, T.Nakatani:Anatomical investigation of position ofcrossing of superficial branch of radial nerve and cephalic vein and its frequency, Structure and Function, 14:1;311, 2015.

122

8070

Gerontological Nursing

Faculty
Title

Name

Field of Specialization

Professor

HIRAMATSU Tomoko community/elderly nursing science

Associate Professor

KOIZUMI Yumi

Assistant Professor

HASHIMOTO Tomoe community/elderly nursing science

community/elderly nursing science

Keywords of Researchgerontological nursing, tactile care, people with dementia and their families, menopausal women, elderly volunteers in thecommunity, learning experience with reality, analyzing the learning effects, frailty in elderly community-dwelling, creation of
personal plans for dementia, dementia enlightenment lecture, foot care, care workers, long-term care facilities, bathing care

Outline of Research
Effectiveness verification of tactile care interventions （for people with dementia and their families 、menopausal women,etc.）、Study of teaching methods Geriatric Nursing (improvement of teaching methods , analysis of learning effects , etc.)、
Association between hypertension status and the screening test for frailty in elderly community-dwelling、Thoughts on“Creation of personal plans for dementia” in the dementia enlightenment lecture for healthy elderly individuals、Foot carefor the elderly、Study of bathing care in elderly long-term care facilities、Study on the cooperation of nurse and care worker

Publications
Originals
8070B001(M.shogenji), C.Yuno, H.Nakada, H.Shimode, C.Sakakibara, T.Hiramatsu:Continence care can prevent urinary
tract infections among elderly patients by reducing the duration of indwelling urinary catheter use, Journal ofJapanese Society of Wound, Ostomy and Continence Management, 19:3;336-345, 2015.

1238080 Public Health Nursing
Faculty
Title

Name

Field of Specialization

Professor

NAKASHIMA Motoko public health nursing

Associate Professor

HAMAZAKI Yuko

public health nursing, study of elder abuse

Associate Professor

SAKURAI Shihomi

public health nursing, Family nursing

Assistant Professor

Tonoyama Noriko

public health nursing

School hygiene

Industrial health

Keywords of Research
Public health nursing-care activity, Public health nursing education, Health promotion, activity of cmmunity organization,
Non-smoking education, School hygiene, Industrial health,Outline of Research
The Public Health nursing study field aims at the science-of-nursing research which can contribute to improvement in theresidents of the area, especially the quality of a life of people with health disturbance, part of a drug abuse prevention
program for junior high school student and health maintenance.

Publications
Originals
8080B001

S.Sakurai, J.Onishi, M.Hirai:Impaired autonomic nervous system activity during sleep in family caregivers of
ambulatory dementia patients in Japan, Biological research for nursing, 17:1;21-28, 2015.

8080B002

T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda,
S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.

Presentations at Conference
International Conference (Presentations)
8080I001

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido,
Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22ndInternational Symposium on Shiftwork and Working Time, Elsinore, 2015.

8080I002

S.Sakurai, Y.Kohno, N.Sakurai, A.Maekawa, M.Hirai:Effects of stress on blood pressure in Japanese family
caregivers of the frail elderly, International collaboration for community health nursing research 2015, Seoul, 2015.

124

8085

Psychiatric and Mental Health Nursing

Faculty
Title

Name

Professor

HASEGAWA Masami

Senior Assistant Professor

TANAKA Koji

Senior Assistant Professor

NAGAYAMA Yutaka

Field of Specialization
depression, suicide prevention, therapeutic nursing, narrative
approachlife-world led care, patient-nurse interrelationship, empathy,
psychiatric and mental health nursing
Minimization for the action limitation, psychiatric nursing for acutephase

Keywords of Research
depression, suicide prevention, therapeutic nursing, narrative approach, life-world led care, patient-nurse interrelationship,
empathy, psychiatric and mental health nursing, minimizing for the action limitation, physical restraint, seclusion, Emotion
Modulation Therapy

Outline of Research
The purpose of our study is to clarify the suicide prevention effect for the depression people by Narrative approach andEmotion Modulation Therapy(EMT). We are trｙing the effect of these methods as new therapeutic nursing for depression
people between our nursing clinic in Japan and Griffth University clinic in Australia.

Publications
Originals
8085B001

K.Tanaka, T.Yoshino, M.Hasegawa, Y.Nagayama, M.Oe:Empathy experienced by psychiatric nurses through thepatient-nurse relationship, Journal of Japan Academy of Nursing Science, 35:184-193, 2015.

8085B002(K.Kawamura), M.Hasegawa :Change of the recognition about prevention for depression through participation inalcoholics anonymous meetings for women alcoholics, The Japan Academy of Psychiatric and Mental HealthNursing, 24:1;51-58, 2015.

8085B003(S.Ohe), M.Hasegawa:Interactions and attitude of nurses who have suffered physical and verbal
abuse from children with Asperger’s disorder, Journal of Society od Nursing Practice, 28:1;1-8, 2015.

Presentations at Conference
International Conference (Presentations)
8085I001

Y.Nagayama, A.Fukutsuka, K.Ikuno, R.Kaneda, Y.Kawasaki, M.Kitamura, Y.Minabe, T.Nagasawa, H.Nakade,M.Oe:Relationship between coercive measures and nursing interventions in university hospital psychiatric wards inJapan, 17th Annual Conference of the International Society of Psychiatric-Mental Health Nurses, Seattle, 2015.

8085I002

M.Hasegawa,K.Nagata:A narrative intervention of depression and suicidal behavior patients with emotion
modulation therapy(EMT), 17th Annual Conference of the International Society of Psychiatric-Mental Health
Nurses, Seattle, 2015.

8085I003

K.Tanaka, T.Yoshino:Structure of nursing activities for promoting resilience in patients with mental disorders, 17th
International Society of Psychiatric Mental Health Nurses, Seattle, 2015.

125

8090

Home Care Nursing

Faculty
Title

Name

Field of Specialization

Professor

MAEDA Shukohome care, home health care nurse

Senior Assistant Professor

KOHNO Yumikohome care nursing, home care nursing teaching method, discharge
supportAssistant Professor

NAKAI Hisao

Home healthcare,Disaster Nursing,Care Management

Assistant Professor

FUKUDA Moriyoshi

Nursing care of pressure uler，Home care

Keywords of Researchhome healthcare nursing, home visit nursing, infection control, visiting nurse service station, continuing education,
education program, Psychiatric Disorder, Community besed Workshop, Recoverry"consept

Outline of Research
In this article, we syowed clearly that the Community besed Work shops for Persons with Psychiatric Disorder, whereintroduced Recoverry"consept prevent the exclusion and separation from the community as functioned of the psychatricservice institution in the community.
Practice and restructuring of the infection control edcation program for home visiting nurses

Publications
Originals
8090B001

H.Nakai:Recognition concerning social environments and supports of the frail elderly with medical care needs,
Journal of Japan Academy of Home Care, 19:1;74-81, 2015.

Presentations at Conference
International Conference (Presentations)
8090I001

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in homenursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.

8090I002

S.Sakurai, Y.Kohno, N.Sakurai, A.Maekawa, M.Hirai:Effects of stress on blood pressure in Japanese family
caregivers of the frail elderly, International collaboration for community health nursing research 2015, Seoul, 2015.

126

8100

Medical Science

Faculty
Title

Name

Field of Specialization

Professor

ISHIBASHI Takaharu

Cardiovascular Pharmacology

Professor

IWAI Kunimitsu

Geriatrics, Circulation, Cell Biology

Professor

KOHNO Hiroyuki

Experimental Pathology, Tumor immunology

Professor

MORIKAWA Yuko

Cardiovascular epidemiology, occupational medicine

Professor

KOJIMA Masami

Study of Cataractogenesis mechanisms, Relation of the intraoculartemperature during infrared exposure and environmental temperature

Professor

HONDA Ryumon

Environment and health, Epidemiology

Keywords of Research
T. Ishibashi/ Nitric Oxide, T. Ishibashi/ Nitrite, T. Ishibashi/ Vasodilators, M. Kojima/electromagnetic radiation, M.
Kojima/ultraviolet exposure, M. Kojima/infrared rays exposure

Outline of Research
T. Ishibashi: Studies of kinetics of NO and NO related compound in vivo and mechanism of action of NO releasing
vasodilators.
M. Kojima: Study of ocular effect from electromagnetic radiation (electric wave, ultraviolet rays, and infrared rays)
exposure.
K. Iwai:Role of the nuclear matrix associated proteins in the regulation of gene expression of the cardiovascular cells.

Publications
Originals
8100B001

Y.Yamada, Y.Noborisaka, M.Ishizaki, M.Yamazaki, R.Honda, H.Yokoyama, T.Kakuma:Different association ofcigarette smoking with GFR estimated from serum creatinine and that from serum cystatin C in the general
population, Clinical and Experimental Nephrology, 19:4;669-677, 2015.

8100B002

K.Kitaoka, S.Masuda, Y.Morikawa, H.Nakagawa:Japanese version of the areas of worklife survey (AWS): Six
mismatches between person and job environment, Japanese Journal of Administrative Science, 28:1;53-63, 2015.

8100B003

M.Nishijo, PT.Tai, NTN.Anh, TN.Nghi, H.Nakagawa, HV.Luong, TH.Anh, Y.Morikawa, T.Waseda, T.Kido,
H.Nishijo:Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal
dioxin exposure in Vietnam: a nested case-control study for neurobiomarker discovery., PLoS One, 10:e0116778,
2015.

8100B004

T.Masuoka, T.Nakamura, M.Kudo, J.Yoshida, Y.Takaoka, N.Kato, T.Ishibashi, N.Imaizumi, M.Nishio:Biphasic
modulation by mGlu5 receptors of TRPV1-mediated intracellular calcium elevation in sensory neurons contributes
to heat sensitivity., British Journal of Pharmacology, 172:4;1020-1033, 2015.

8100B005

M.Kojima, Y.Suzuki, CY.Tsai, K.Sasaki, K.Wake, S.Watanabe, M.Taki, Y.Kamimura, A.Hirata, K.Sasaki,
H.Sasaki:Characteristics of ocular temperature elevations after exposure to quasi- and millimeter waves (18-40
GHz), Journal of Infrared Millimeter and Terahertz Waves, 36:4;390-399, 2015.

127

8100B006

M.Ishizaki, Y.Suwazono, T.Kido, M.Nishijo, R.Honda, E.Kobayashi, K.Nogawa, H.Nakagawa:Estimation of
biological half-life of urinary cadmium in inhabitants after cessation of environmental cadmium pollution using amixed linear model, Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk
Assessment, 32:8;1273-1276, 2015.

8100B007(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:Renal tubular
dysfunction increases mortality in the Japanese general population living in cadmium non-polluted areas, Journal of
Exposure Science & Environmental Epidemiology, 25:4;399-404, 2015.

8100B008(IR.White), E.Rapsomaniki; Emerging Risk Factors Collaboration:Covariate-adjusted measures of discrimination forsurvival data, Biometrical Journal, 57:4;592-613, 2015.

8100B009(Y.Suwazono), K.Nogawa, Y.Morikawa, M.Nishijo, E.Kobayashi, T.Kido, H.Nakagawa, K.Nogawa:All-cause
mortality increased by environmental cadmium exposure in the Japanese general population in cadmium nonpolluted areas, Journal of Applied Toxicology, 35:7;817-823, 2015.

8100B010(K.Sasaki), Y.Isimura, K.Fujii, K.Wake, S.Watanabe, M.Kojima, R.Suga, O.Hashimoto:Dielectric property
measurement of ocular tissues up to 110 GHz using 1 mm coaxial sensor, Physics in Medicine and Biology,
60:6273-6288, 2015.

Reviews
8100C001(Y.Suzuki), M.Taki, M.Kojima:Dosimetry on high-frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal, IEICE technical report, 1-6, 2015.

8100C002

T.Masuoka, T.Ishibashi, M.Nishio:Biphasic modulation of noxious heat sensitivity in sensory neurons by peripheral
metabotropic glutamate receptors, Inflammation and Cell Signaling, 2:602, 2015.

8100C003(K.Kitaoka), S.Masuda, Y.Morioka, H.Nakagawa:Latest outcomes from a study of job burnout and work
environment, Job stress research, 22:2;113-118, 2015.

8100C004

J.Yoshida, T.Ishibashi, T.Masuoka, N.Imaizumi, M.Nishio:Ca2+ Signalimg molecules STIM1/Orail and Cancer,
Journal of Kanazawa Medical University, 40:2・3;69-77, 2015.

Presentations at Conference
International Conference (Presentations)
8100I001

M.Sakurai, K.Nakamura, SY.Nagasawa, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, K.Miura, H.Nakagawa:Different
Influences of Dietary Carbohydrate and Fat on the Risk of Type 2 Diabetes in Japanese with Different Degrees ofObesity, 75th Scientific Sessions,American Diabetes Association, Boston, 2015.

8100I002

SY.Nagasawa, M.Sakurai, K.Nakamura, K.Miura, Y.Morikawa, M.Ishizaki, T.Kido, Y.Naruse, Y.Suwazono,
K.Nogawa, H.Nakagawa:Longitudinal association between body weight change and 6-year change of serum
cholesterol levels in Japanese men, AHA EPI/LYFESTYLE 2015, Baltimore, 2015.

8100I003(Y.Suzuki), M.Sasaki, S.Onishi, R.Imai, M.Takamura, M.Taki, J.Chakarothai, K.Sasaki, K.Wake, S.Watanabe,
M.Kojima, CY,Tsai, H.Sasaki:Acceleration of large-scale multi-physics simulation for biomedical EMC with manycore architecture based computing, URSI AT-RASC, Canary Istands, 2015.

8100I004

Y.Morikawa, M.Sakurai, S.Nagasawa, K.Nakamura, M.Nakashima, M.Ishizaki, H.Nakagawa, T.Kido,
Y.Naruse:Interaction of shift work and aging on sleep: a longitudinal study among factory workers, 22ndInternational Symposium on Shiftwork and Working Time, Elsinore, 2015.

8100I005(Y.Suzuki), M.Kojima, A.Kik, M.Taki:Non-destructive 3D temperature measurement for dosimetries of the thermal
dose due to high frequency electromagnetic field exposure with microencapsulated thermo-chromic liquid crystal,First PEM International Workshop in Kyoto, Kyoto, 2015.

128

Department of General Education

8610

Natural Sciences

Faculty
Title

Name

Field of Specialization

Professor

TANAKA Ichiro

Scientific sociology, History of technology

Professor

MATSUDA Hiroo

Lorentz manifolds, Curves in Euclidean space

Associate Professor

SHOJI Hiroki

Developmental Biology, Molecular Biology, Biochemistry

Associate Professor

HASHIMOTO
Mitsumasa

Radiation Biology, Cell Biology

Senior Assistant Professor

ARIKAWA Tomohiro

Immunology, Developmental Biology

Senior Assistant Professor

MAEDA Masayo

Molecular oncology, Metastasis of Cancer Cells

Senior Assistant Professor

INOUE Tomoki

Graph theory in toplogy

Assistant Professor

OKUDA Koichi

Fixed-quantity rating system in the heart nuclear medicine

Keywords of Research
Bertrand curveMannheim curve, isotropy group, harmonic form, class number, ideal class group, cyclotomic fieldMannheim
curve, Frenet frame, graph theory in topology, topological polyhedron, , Nuclear medicine Nuclear cardiology, Imaging,
Image processingSPECT, DNA repair, 53BP1, NHEJ, HR, Ionizing Radiation, DNA double strand breaks (DSBs), history ofscience, history of technologyGalileo GalileiIsaac NewtonVenetian patent law, , Metastasis, Metastasis Inducing Gene,
RhoGDIβ(LyGDI/D4GDI/RhoGDI2), , ultrastructure, pharynxspongemetamorphosis, immunoelectron microscopy,
neurosynapsneurosecretory cell, lectin, galectinβ-galactoside, Xenopusdevelopment, placenta

Outline of Research
１）Functional analysis of Galectins a family of ・-galactosides binding proteins. a）Roles of Galectins in animal development.
b）Roles of Galectins in the placentation and immune tolerance.
Hashimoto:Function of DNA repair enzymes especially protection mechanisms against DNA double strand breaks induced
ionizing radiation especially protection mechanisms against DNA double strand breaks induced ionizing radiation
Okuda:The aim of our research is to develop a computer algorithm for the quantitative assessment of myocardial perfusionand sympathetic nerve activity in the nuclear cardiology.
MAEDA:Rho guanine nucleotide dissociation inhibitors (RhoGDIs) regulate the ctivity of Rho family GTPases. Our studies
have indicated that RhoGDIβLyGDI/D4GDI/RhoGDI2) plays a role in cancer metastasis.Further investigation of thedetails of RhoGDIβ's role in cancer progression and metastasis is important. It will lead to a better treatment for cancer.
Matsuda : We define a generalized Mannheim curve in Euclidean space. And we give characterizations of generalized
Mannheim curve and examples of generalized Mannheim curve.
Inoue:We extend the Graph Theory and define a topologicalpolyhedron which coverd on closed surface of genus g. We give
characterizations and example of the topological polyhedron.
TANAKA:The research theme is the history of early modern science and technology. The topics being studied include
Galileo Galilei and Venetian Patent Law enacted in 15th century.

129

Publications
Originals
8610B001(S.Matsuo), K.Nakajima, M.Onoguchi, H.Wakabayash, K.Okuda, S.Kinuya:Nuclear myocardial perfusion imaging
using thallium-201 with a novel multifocal collimator SPECT/CT: IQ-SPECT versus conventional protocols innormal subjects, Annals of Nuclear Medicine, 29:5;452-459, 2015.

8610B002(K.Nakajima), S.Matsuo, H.Wakabayashi, H.Yokoyama, H.Bunko, K.Okuda, S.Kinuya, K.Nystrom,
L.Edenbrandt:Diagnostic performance of artificial neural network for detecting ischemia in myocardial perfusion
imaging., Japanese Circulation Journal, 79:7;1549-1556, 2015.

8610B003

E.Simamura, T.Arikawa, T.Ikeda, H.Shimada, H.Shoji, H,Masuta, Y.Nakajima, H.Otani, H.Yonekura,
T.Hatta:Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via
melanocortin receptors 1, 2 and 5, PLoS One, 10:4;e0123232, 2015.

8610B004

T.Ota, M.Maeda, M.Okamoto, M.Tatsuka:Positive regulation of Rho GTPase activity by RhoGDIs as a result of
their direct interaction with GAPs, BMC Systems Biology, 9:3, 2015.

8610B005(Y.Nonaka), T.Ogawa, H.Yoshida, H.Shoji, N.Nishi, S.Kamitori, T.Nakamura:Crystal structure of a Xenopus laevis
skin proto-type galectin, close to but distinct from galectin-1, Glycobiology, 25:7;792-803, 2015.

Presentations at Conference
International Conference (Presentations)
8610I001(S.Kawahara), H.Masuda, D.Erickson, J.Moore, A.Suemitsu, Y.Shibuya.:Quantifying the effects of vowel quality andpreceding consonants on jaw displacement: Japanese data., Lexicon Festa-3, Tokyo, 2015.

8610I002

H. Shiga, J.Taki, K.Okuda, N.Watanabe, H.Tonami, M.Furukawa, S.Kinuya, T.Miwa:Prognostic value of olfactory
nerve assessment with olfacto-scintigraphy in patients with olfactory disorders, The 37th annual meeting of the
Association for Chemoreception Sciences, Bonita Sorings, 2015.

8610I003

Y.Sunatani, M.K.Sharma, R.P.Kamdar, T.Matsui, R.Sakasai, M.Hashimoto, Y.Matsumoto, K.Iwabuchi:
Phosphorylation-mediated Regulation of Apoptosis By NHEJ-protein XRCC4, 15th International Congress ofRadiation Research, Kyoto, 2015.

8610I004

R.Sakasai, Y.Sunatani, T.Matsui, M.Hashimoto, K.Iwabuchi:Ubiquitin-dependent Activation of DNA-PKcs Leads
to Chromosomal Aberration in Response to One-ended DNA Double Strand Breaks, 15th International Congress ofRadiation Research, Kyoto, 2015.

8610I005

K.Okuda, K.Nakajima, Y.Kirihara, S.Sugino, S.Matsuo, J.Taki, M.Hashimoto, S.Kinuya:Standardization of cardiac
I-123 metaiodobenzylguanidine washout rates derivedfrom late 3 and 4 hours imaging, ICNC12,Nuclear Cardiology
and Cardiac CT., Madrid, 2015.

8610I006

K.Okuda, N.Nakajima, K.Nystrom, L.Edenbrandt, S.Matsuo, H.Wakabayashi, M.Hashimoto, S.Kinuya:Comparisonof two software packages for the evaluation of the left ventricular dyssynchrony by phase analysis in gatedmyocardial perfusion SPECT, ICNC 12,Nuclear Cardiology and Cardiac CT, Madrid, 2015.

130

8620

Human Sciences

Faculty
Title

Name

Field of Specialization

Professor

SHIBUYA Yoshiho

English linguistics, Phonetics

Professor

HARA Akira

Austria literature led by Hofmannsthal

Associate Professor

KOCHI Munehiro

Interpretationen von Goethes Werken, Begriff von Bildung

Senior Assistant Professor

HONDA Kojiro

Ethics of technology

Senior Assistant Professor

KIKUCHI Takeshi

Senior Assistant Professor

IKENAKA Masami

English Education

Senior Assistant Professor

CRAIG Woods

English, Medical English

Senior Assistant Professor

BURKE STEVEN
ThomasEnglishSenior Assistant Professor

TSUDA Ryosuke

Exercise physiology, Pedagogy of physical education

Keywords of Research
articulatory phonetics, acoustic phonetics, English phonology, Japanese phonology, pronunciation, L2 researchlanguage
acquisition, medical research article, novel, individualism, quest, existentialism, Buildungsroman, humor, irony, narration,
suffering, humanity cross-cultural differences, cultural variation, NLP, Python programming language, medical Englishelearning, , logic, metaphysics, form, content, predicate, category, deduction, induction, matterbeing, substance, definion,
Phenomenology, Philosophy of Technology, Ethics of Technology, Engineering Ethics, Robo-ethics, Medical Ethics,
Cognitive Science of Learning, History of Science, Philosophy of Science, , exercise prescription, lifestyle-related diseases,
improvement of physical fitness, soccer, PE class, , end of the century, culture, the middle Ages, Modern times, Europe,

Outline of ResearchHara : In the German-language area from the end of the 19th century to the beginning of the 20th century many prominent
intellects appeared in various fields of culture. Hofmannsthal is also one of such intellects in the field of literature. He
almost spent the entirety of his life in Vienna, but his influence reaches the whole spiritual world of modern Europe. I
analyze his acquaintanceship with intellects of that time and extract the essence of the modern culture in the Germanlanguage area and furthermore in all Europe many prominent intellects appeared in various fields of culture. Hofmannsthal isalso one of such intellects in the field of literature. He almost spent the entirety of his life in Vienna but his influence
reaches the whole spiritual world of modern Europe. I analyze his acquaintanceship with intellects of that time and extractthe essence of the modern culture in the German-language area and furthermore in all Europe.
Kouchi : Das Europa im zweiten Halfte des 18. Jahrhunderts ist die Wendezeit von der noch einflussreichen
mittelalterlichnen Denkweise zur neuen modernen wie sie der Historiker Reinharｔ Kosellecｋ die “Sattelzeit“ nennt. Wie
man sich damals mit dem Wechsel des Paradigmas auseinander setzte mochte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen mochte ich im Fall vom deutschen Dichter Goethe
untersuchen und in seinen Werken wie Romanen und Dramen zeigen
Our research includes prevention of lifestyle-related diseases for middle aged and elderly persons. In addition our research
focuses on improvement of physical fitness through soccer in PE classes for children.
Shibuya: Main research topic is Japanese speakers' pronunciation of English. How phonology (what is in the mind of
speakers) and phonetics (mostly the gestural movement of articulators) of L1 (here Japanese) influence the pronunciation ofJapanese speakers of English is studied, Japanese) influence the pronunciation of Japanese speakers of English is studied.
Burke:My most recent research interest has been the connection and power that extensive reading has on English
acquisition for EFL students.

131

Woods:Using computer software for natural language processing of the English found in medical articles to determine themost commonly used words forms and structures.
Ikenaka:My research topic is how to utilize e-learning materials effectively to raise the motivation of students.
HONDA:It is inquiring about the ethics of technology. Tradition of knowledge" has considered the problem what kind of
responsibility occurs why in possible one and the side which inherits knowledge again by the mainly phenomenological
technique.

Presentations at Conference
International Conference (Presentations)
8620I001(S.Kawahara), H.Masuda, D.Erickson, J.Moore, A.Suemitsu, Y.Shibuya.:Quantifying the effects of vowel quality andpreceding consonants on jaw displacement: Japanese data., Lexicon Festa-3, Tokyo, 2015.

8620I002(R.Iwata), D.Erickson, Y.Shibuya, A.Suemitsu:Articulation of phrasal stress in Mandarin Chinese., Proceedings ofAcoustical Society of Japan, fall meeting, Tokyo, 2015.

132

Affiliated Institution

9030

Northern Noto Institute for Community Medicine

Faculty
Title

Name

Field of Specialization

Professor

NAKAHASHI Takeshi Geriatrics, Circulation, Hypertension, Atherosclerosis, Cardiology

Keywords of Research
The Elderly, Rural Medicine, Medical Needs,

Outline of Research
The aim of the research is to clarify the changes of diseases in the aging area and to consider the future medical needs.

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9050

FDD-MB Center

Faculty
Title

Name

Field of Specialization

Director

TAKABAYASHI Haruo fetal medicine, DNA medicine.

Keywords of Research
FDD-MB, single cell technology, NRBC, noninvasive fetal diagnosis, DNA diagnosis, fetal cell, woman's health, DNA array,
Lab on a Chip,

Outline of ResearchMission of Center for FDD-MB
1. elucidation of the relationship between fetal cells and mother's health
2. development of fetal DNA diagnosis from maternal blood (FDD-MB)
3. development of single cell technology

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Himi Municipal Hospital

9100

Himi Municipal Hospital

Faculty
Title

Name

Field of Specialization

Director

SAITO Hitoshi

Surgical treatment of hepatobiliary and pancreatic disease

Professor

FUKUDA Akihiro

Cardiology

Professor

SAKAMOTO Shigeru

Cardiovascular Surgery

Professor

MORIYAMA Manabu

Kidney transplantation，Urolithiasis

Professor

HATASHIMA Sunao

Anesthesiology/Resuscitation studies

Professor

MATSUKI Nobuo

Oncology Surgery

Associate Professor

ITO Tomohikoadrenal diseases, diabetes, thyroid diseases

Associate Professor

IGUCHI Masaharu

Respiratory Medicine

Associate Professor

KUGINUKI Yasuaki

Medical Radiography

Associate Professor

IKEBUCHI Kimihiro

Orthopaedic Surgery

Associate Professor

MATSUNO Hideo

Allergy，Otorhinolaryngology

Associate Professor

MATSUI Toshiaki

Oral & Maxilofacial Surgery

Senior Assistant Professor

KIYOSAWA Jun

Cardiology

Senior Assistant Professor

SAITO Atsushi

Nephrology

Senior Assistant Professor

AOKI Nobuyuki

Orthopaedic Surgery

Senior Assistant Professor

OHURA Kazuko

Otorhinolaryngology

Senior Assistant Professor

KAWASAKI Masanori Anesthesiology/Resuscitation studies

Assistant Professor

MIZUNO Takuro

Cardiology

Assistant Professor

HIGASHIKAWA
Toshihiro

Gerontology

Assistant Professor

ISHIGAMI Keiichiro

Gerontology

Assistant Professor

MUKAI Hirokado

Oncology Surgery

Assistant Professor

HAYASHI Kei

Oncology Surgery

Assistant Professor

NAKAMURA Kisuke

Oncology Surgery

Assistant Professor

SAKAMOTO Daisuke Cardiovascular Surgery

Assistant Professor

KUSABA Eizo

neurosurgery

Publications
Originals
9100B001

T.Higashikawa, Y.Hamazaki, O.Iritani, T.Morita, T.Himeno, T.Okuno, H.Yano, K.Watanabe, M.Okuro, T.Kanda,
S.Morimoto:Blood pressure and disability-free survival among community-dwelling diabetic and non-diabetic
elderly patients receiving antihypertensive treatment, Geriatrics Gerontology International, 16:3;365-373, 2015.

9100B002

S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya:Interactions of
DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney International., 88:3;479-489,
2015.

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Reviews
9100C001

T.Nagai, K.Nitta, M.Kanasaki, D.Koya, K.Kanasaki:The biological significance of angiotensin-converting enzyme
inhibition to combat kidney fibrosis, Clinical and Experimental Nephrology, 19:1;65-74, 2015.

Presentations at Conference
International Conference (Presentations)
9100I001

S.Maeda, T.Takiuti, Y.Kohno, H.Nakai, M.Fukuda, M.Moriyama:Factors related to catheter blockage in homenursing care patients with long-term indwelling catheters, 16th international EAUN meeting, Madrid, 2015.

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