Thoracic Surgery
Principal Investigator Yukio SatoE-mail.address ysato@mdd.tsukuba.ac.jp
Other Faculty Members

Professor Hideo Ichimura: ichimura@tmch.or.jp
Associate Professor Yukinobu Goto: ygoto@mdd.tsukuba.ac.jp
Associate Professor Shiji Kikuchi: S.kikuchi@md.tsukuba.ac.jp
Associate Professor Naohiro Kobayashi: naohiro.kobayashi@md.tsukuba.ac.jp

Major Scientific Interests of the Group
Lung cancer has become a major cause of death in most of countries. Surgical resection is the mosteffective for the treatment of lung cancer. Minimal invasive video assisted thoracic surgery (VATS)
lobectomy appears to be a safe and effective procedure for treatment of lung cancer. We are making
progress not only in reducing surgical stress but also in improving the quality of surgery by developing
original devises and techniques. We are focusing also on the multimodal treatment of lung cancer,
surgical simulation and estimation of postoperative lung regeneration and function using 3D-CT,
development of novel sealant material for surgery, mechanism of invasion of lung cancer, and themechanism of acute lung injury.
Projects for Regular Students in Doctoral or Master’s Programs
1) Surgical simulation and estimation of postoperative lung regeneration and function using 3D-CT
2) Development of novel sealant material for surgery3) Mechanism of invasion of lung cancer
4) Mechanism of acute lung injury
Study Programs for Short Stay Students (one week – one trimester)1) Surgical simulation and estimation of postoperative lung regeneration and function using 3D-CT
2) Mechanism of acute lung injury
Selected Publications
1) Ashoka Indranatha Wijesinghe, Naohiro Kobayashi, Shinsuke Kitazawa, Naoki Maki, Takahiro Yanagihara,
Yusuke Saeki, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato. Sex‑specifc emphysematouschanges evaluated by a three‑dimensional computed tomography volumetric analysis among patients withsmoking histories who underwent resection for lung cancer. Surgery Today. 54(2), 113-121, 2024.2
2) Naoki Yoshimura, Yukio Sato, Hiroya Takeuchi, Tomonobu Abe , Shunsuke Endo, Yasutaka Hirata , MichikoIshida , Hisashi Iwata, Takashi Kamei , Nobuyoshi Kawaharada, Shunsuke Kawamoto, Kohji Kohno, Hiraku
Kumamaru, Kenji Minatoya, Noboru Motomura, Rie Nakahara, Morihito Okada, Hisashi Saji, Aya Saito,
Masanori Tsuchida, Kenji Suzuki, Hirofumi Takemura, Tsuyoshi Taketani, Yasushi Toh, Wataru Tatsuishi,
Hiroyuki Yamamoto, Takushi Yasuda, Masayuki Watanabe , Goro Matsumiya , Yoshiki Sawa, Hideyuki
Shimizu, Masayuki Chida. Thoracic and cardiovascular surgeries in Japan during 2021 : Annual report by theJapanese Association for Thoracic Surgery. General Thoracic & Cardiovascular Surger. 2024.2
3) Sato Y, Yamamoto H, Ikeda N, Konishi H, Hibi T, Endo S, Inoue M, Okada Y, Shintani Y, Toyooka S,
Nakamura H, Hoshikawa , Chen-Yoshikawa TF, Uramoto H, Tsubochi Y, Kakizoe T, Chida M, Yoshino I.
The consecutive impact of COVID-19 on thoracic surgical procedures in Japan: an analysis of data from the
National Clinical Database. Surg Today. 54(6), 627-633, 2024.1
4) Matsumiya, Goro; Sato, Yukio; Takeuchi, Hiroya; Abe, Tomonobu; Endo, Shunsuke; Hirata, Yasutaka; Ishida,
Michiko; Iwata, Hisashi; Kamei, Takashi; Kawaharada, Nobuyoshi; Kawamoto, Shunsuke; Kohno, Kohji;Kumamaru, Hiraku; Minatoya, Kenji; Motomura, Noboru; Nakahara, Rie; Okada, Morihito; Saji, Hisashi;
Saito, Aya; Shimizu, Hideyuki; Suzuki, Kenji; Takemura, Hirofumi; Taketani, Tsuyoshi; Toh, Yasushi;
Tatsuishi, Wataru; Yamamoto, Hiroyuki; Yasuda, Takushi; Watanabe, Masayuki; Yoshimura, Naoki;
Tsuchida, Masanori; Sawa, Yoshiki. Thoracic and cardiovascular surgeries in Japan during 2020: Annual
report by the Japanese Association for Thoracic Surgery. General Thoracic & Cardiovascular Surger. 72(1),61-94, 2024.1
5) Kazuto Sugai, Naohiro Kobayashi, Yusuke Saeki, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio
Sato. Silicone stent placement using a rigid bronchoscope via a tracheostoma in a patient with
postpneumonectomy syndrome. General Thoracic and Cardiovascular Surgery Cases. 2023.12
6) Kazuto Sugai , Yasuharu Sekine , Tomoyuki Kawamura , Takahiro Yanagihara , Yusuke Saeki , Shinsuke
Kitazawa , Naohiro Kobayashi , Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato. Sphericity oflymph nodes using 3D-CT predicts metastasis in lung cancer patients. Cancer Imaging. 23(1), 124, 2023.12
7) Tomoyuki Kawamura, Yasuharu Sekine, Kazuto Sugai, Takahiro Yanagihara, Yusuke Saeki, Shinsuke
Kitazawa, Naohiro Kobayashi, Yukinobu Goto, Hideo Ichimura, Tomohiro Ohigashi, Kazushi Maruo & Yukio
Sato. Three-dimensional analysis reveals a high incidence of lung adenocarcinoma in the upper region. Surg
Today. 2023.12
8) Takahiro Yanagihara, Tomoyuki Kawamura, Kenji Minagi, Yasuharu Sekine, Kazuto Sugai, Hideo Ichimura,
Yukio Sato. Successful long-term management for postoperativesternal infectin with multiple dissemionatedlymphadenitis caused by Mycobacterium abscessus. Surgical Case Reports. 9(1), 2023.8
9) Kazuto Sugai, Naohiro Kobayashi, Kawamura Tomoyuki,Yukinobu Goto, Hideo Ichimura, Yukio Sato. A
novel approach to the lung apex avoiding dissection of severe pleural adhesions. General Thoracic andCardiovascular Surgery. 71(8), 487-490, 2023.8
10) Minatoya K, Sato Y, Toh Y, Abe T, Endo S, Hirata Y, Ishida M, Iwata H, Kamei T, Kawaharada N,
Kawamoto S, Kohno K, Kumamaru H, Matsumiya G, Motomura N, Nakahara R, Okada M, Saji H, Saito A,
Shimizu H, Suzuki K, Takemura H, Taketani T, Takeuchi H, Tatsuishi W, Yamamoto H, Yasuda T, Watanabe
M, Yoshimura N, Tsuchida M, Sawa Y. Thoracic and cardiovascular surgeries in Japan during 2019 : Annual
report by the Japanese Association for Thoracic Surgery. [Review]. General Thoracic & Cardiovascular
Surger. 71(10), 595-628, 2023.7
11) Keisuke Kobayashi, Hideo Ichimura, Shuntaro Kawabata, Hisashi Suzuki, Katsuyuki Endo, Naohiro
Kobayashi, Shinji Kikuchi, Yukinobu Goto, Yukio Sato. Comparison of patient-reported outcomes and clinicaloutcomes between pleurectomy and pleural covering added to thoracoscopic bullectomy for primary
spontaneous pneumothorax. J Thorac Dis. 15(7), 3818-3828, 2023.7
12) Yusuke Saeki, Junko Okamura, Sho Ueda, Yukio Sato. Middle lobe pulmonary artery branch running ventral
to the upper lobe pulmonary vein. European Journal of Cardio-Thoracic Surgery. 64(1), 2023.7
13) Hideo Ichimura , Keisuke Kobayashi, Masahiko Gosho, Yasuharu Sekine, Kazuto Sugai, Tomoyuki
Kawamura, Yusuke Saeki, Hisashi Suzuki, Naohiro Kobayashi ,Yukinobu Goto, Yukio Sato. Relationshipbetween changes in pulmonary function and patient-reported outcomes of lung cancer surgery. Surgery Today.
2023.6
14) Yukinobu Goto, Yuji Hiramatsu, Naohide Ageyama, Bryan J Mathis, Naoki Maki, Muneaki Matsubara,
Yoshiaki Inoue, Yukio Sato. Myeloid Progenitor Inhibitory Factor-1 (CCL23) Inhibits Lung Leukocyte
Recruitment in a Primate Cardiopulmonary Bypass-Induced Pulmonary Ischaemia Model. Heart Lung Circ.
32(3), 424-433, 2023.3
15) Kikuchi Shinji, Sekine Yasuharu, Nakaoka Koji, Kobayashi Naohiro, Suzuki Hisashi, Goto Yukinobu,
Ichimura Hideo, Kioshima Moriyuki, Sato Yukio, Surgery for small-cell lung cancer: Clinical characteristics
and prognostic factors, cancer science,114(1:Sl), 627, 2023.3
16) Naohiro Kobayashi,Yusuke Saeki, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato. Impacts ofpleural adhesions on lobectomies for malignant lung tumors. General Thoracic and Cardiovascular Surgery
Cases. 70(12),1042-1047,2022.12
17) Yukio Sato, Hiroyuki Yamamoto, Norihiko Ikeda, Hiroshi Konishi, Shunsuke Endo, Yoshinori Okada,Haruhiko Kondo, Yasushi Shintani, Shinichi Toyooka, Hiroshige Nakamura, The impact of COVID-19 on
thoracic surgical procedures in Japan: Analysis of data from the National Clinical Database. Lung Cancer.
172,127-135.2022.10

18) Yasushi Hoshikawa, Toyofumi Fengshi Chen-Yoshikawa, Ichiro Yoshino, Tadao Kakizoe, Masayuki Chida
19) Takahiro Yanagihara, Naoki Maki1, Tomoyuki Kawamura, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu
Goto, Hideo Ichimura, Shiharu Watanabe, Tetsushi Taguchi, Yukio Sato. Alaska pollock gelatin sealant shows
long-term efficacy and safety in a pulmonary air leakage rat model. Eur J Cardiothorac Surg. 62(5),2022.10
20) Takahiro Yanagihara, Naohiro Kobayashi, Yusuke Saeki, Shinji Kikuchi, Yukinobu Goto & Yukio Sato. Left
thoracoscopic sympathectomy for refractory ventricular arrhythmias. General Thoracic and Cardiovascular
Surgery. 70(10),920-923, 2022.10, 119(31), 2022.7
21) Ueda S, Yamashita S, Nakajima M, Kumamoto T, Ogawa C, Liu YY, Yamada H, Kubo E, Hattori N,
Takeshima H, Wakabayashi M, Iida N, Shiraishi Y, Noguchi M, Sato Y, Ushijima T. A quantification methodof somatic mutations in normal tissues and their accumulation in pediatric patients with chemotherapy. Proc
Natl Acad Sci USA.
22) Tomoyuki Kawamura, Naohiro Kobayashi, Yukinobu Goto, Yukio Sato. Increase of Micro-vessels Beneaththe Pleural Surface on CT Predicts Pleural Adhesions. Thorac Cardiovasc Surg. 2022.6
23) Takahiro Yanagihara, Naohiro Kobayashi, Tomoyuki Kawamura, Shinji Kikuchi, Yukinobu Goto, Hideo
Ichimura , Yukio Sato. Rapid enlargement of pulmonary benign metastasizing leiomyoma with fluidcontaining cystic change. Surg Case Rep.8(1), 2022.5
24) Naoki Maki, Harumi Sakamoto, Yu Takata; Keisuke Taniguchi, Ashoka Wijesinghe,,Junko Okamura,Tomoyuki Kawamura; Yakahiro Yanagihara, Yusuke Saeki ; Shinsuke Kitazawa, Naohiro Kobayashi, Shinji
Kikuchi, Yukinobu Goto, Hideo Ichimura,,Yukio Sato, Hisako Yanagi. Effect of Pulmonary Training forCommunity-Dwelling Frail Elderly with Chronic Stroke: A Randomized Controlled Pilot Trial.23(30),140148,2021.11
25) Shinsuke Kitazawa, Ashoka Indranatha Wijesinghe , Naoki Maki, Takahiro Yanagihara, Yusuke Saeki
Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato. Predicting Respiratory
Complications Following Lobectomy Using Quantitative CT Measures of Emphysema. Int J Chron Obstruct
Pulmon Dis. 4(16),2523-2531,2021.9
26) Ichimura H, Kobayashi K, Gosho M, Nakaoka K, Yanagihara T, Saeki Y, Sato Y. Comparison of
Postoperative Quality of Life and Pain with and without a Metal Rib Spreader in Patients Undergoing
Lobectomy through Axillary Mini-Thoracotomy for Stage I Lung Cancer. Ann Thorac Cardiovasc Surg.
2021.927) Takahiro Yanagihara, Yasuharu Sekine, Kazuto Sugai, Naoki Maki, Yusuke Saeki, Shinsuke Kitazawa,
Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura, Yukio Sato. Risk factors of middle lobe
bronchus kinking following right upper lobectomy. Journal of Thoracic Disease.13(5),3010-3020,2021-5
28) Ueda Sho, Yamashita Satoshi, Watanabe Shunichi, Watanabe Mika, Motoi Noriko, Noguchi Masayuki, Sekine
Shigeki, Sato Yukio, Ushijima Toshikazu. Influence of degree of DNA degradation in formalin-fixed andparaffin-embedded tissue samples on accuracy of genome-wide DNA methylation analysis.
Epigenomics.13(8),565-576.2021.4
29) Junko Okamura , Naohiro Kobayashi, Takahiro Yanagihara, Shinji Kikuchi, Yukinobu Goto and Yukio Sato.
Successful treatment of bilateral empyema with bilateral fistulae using free intercostal muscle flap. Surgical
Case Report. 2021.2
30) Hideo Ichimura , Keisuke Kobayashi, Masahiko Gosho, Kojiro Nakaoka, Takahiro Yanagihara, Sho Ueda,
Yusuke Saeki , Kentaro Araki , Tomoyuki Kawamura , Yukio Sato. Trajectory and profile of quality of life inpatients undergoing lung resection for lung cancer during hospitalization according to the EQ-5D. General
thoracic and cardiovascular surgery. Equp.2021-2
31) Yusuke Saeki , Shinsuke Kitazawa , Takahiro Yanagihara , Naohiro Kobayashi , Shinji Kikuchi , Yukinobu
Goto , Hideo Ichimura , Yukio Sato. Consolidation volume and integration of computed tomography values on
three-dimensional computed tomography may predict pathological invasiveness in early lungadenocarcinoma.51(8),230-1327. 2021.2
32) Hideo Ichimura, Keisuke Kobayashi, Masahiko Gosho, Kojiro Nakaoka, Takahiro Yanagihara, Sho Ueda,
Yusuke Saeki, Naoki Maki, Naohiro Kobayashi, Shinji Kikuchi , Hisashi Suzuki , Yukinobu Goto , Yukio
Sato, Preoperative predictors of restoration in quality of life after surgery for lung cancer. 12(6),835844,2021.1
33) Masaharu Inagaki, Hideo Ichimura, Shingo Usui, Kesato Iguchi, Osamu Ishibashi, Ryota Nakamura, Yoshihisa

Inage, Hisashi Suzuki, Moriyuki Kiyoshima, Koichi Kamiyama, Masaki Kimura, Susumu Yoshida, Mitsuaki
Sakai, Naohiro Kobayashi, Kinya Furukawa, Hiroaki Satoh, Nobuyuki Hizawa , Yukio Sato. A populationbased study of outcomes in patients with surgically resected non-small cell lung cancer with anaplastic
lymphoma kinase-rearranged mutations: A matched-pair study. Molecular and clinicaloncology.14(1),11.2021.1
34) Shimizu H, Okada M, Toh Y, Doki Y, Endo S, Fukuda H, Hirata Y, Iwata H, Kobayashi J, Kumamaru H,
Miyata H, Motomura N, Natsugoe S, Ozawa S, Saiki Y, Saito A, Saji H, Sato Y, Taketani T, Tanemoto K,
Tangoku A, Tatsuishi W, Tsukihara H, Watanabe M, Yamamoto H, Minatoya K, Yokoi K, Okita Y, Tsuchida
M, Sawa Y. Thoracic and cardiovascular surgeries in Japan during 2018 : Annual report by the Japanese
Association for Thoracic Surgery. Gen Thorac Cardiovas Surg. 69,179-212,2021-1
35) ShinsukeKitazawa, Naohiro Kobayashi, Sho Ueda, Yuki Enomoto, Yoshiaki Inoue, Toshihiro Shiozawa, Ikuo
Sekine, Hitomi Kawai, Masayuki Noguchi, Yukio Sato. Successful use of extracorporeal membrane
oxygenation for airway-obstructing lung adenocarcinoma. Thoracic cancer. 10,3024-3028,2020.10
36) Naoki Maki, Harumi Sakamoto, Yu Takata, Yuki Mutsukura, Wijesinghe Ashoka, Takahiro Yanagihara,
Yusuke Saeki, Shinsuke Kitazawa, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Hideo Ichimura,
Yukio Sato, Hisako Yanagi. Factors related to the physical and mental components of quality of life in thecommunity-dwelling frail the elderly. Journal of Physical Therapy Science 32(9),557-562,2020-937) Hideyuki Shimizu, Morihito Okada, Akira Tangoku, Yuichiro Doki, Shunsuke Endo, Hirotsugu Fukuda,
Yasutaka Hirata, Hisashi Iwata, Junjiro Kobayashi, Hiraku Kumamaru, Hiroaki Miyata, Noboru Motomura,
Shoji Natsugoe , Soji Ozawa, Yoshikatsu Saiki, Aya Saito, Hisashi Saji, Yukio Sato, Tsuyoshi Taketani,Kazuo Tanemoto, Wataru Tatsuish , Yasushi Toh, Hiroyuki Tsukihara, Masayuki Watanabe. Thoracic andcardiovascular surgeries in Japan during 2017 : Annual report by the Japanese Association for Thoracic
Surgery Gen Thorac Cardiovas Surg, 68(4),414-449,2020.4
38) ,Shinsuke Kitazawa, Yusuke Saeki, Naohiro Kobayashi, Shinji Kikuchi, Yukinobu Goto, Yukio Sato, Threedimensional mean CT attenuation value of pure and part-solid ground-glass lung nodules may predictinvasiveness in early adenocarcinoma, Clinical Radiology,74(12),2019.12
39) Sato Yukio, How should we decide the optimum intraoperative fluid and colloid usage in pulmonary
resection? Journal of Thoracic Disease.11(11), E204-205
40) Hideo Ichimura, Takeshi Nawa, Yusuke Yamamoto, Kei Shimizu, Keisuke Kobayashi, Shinsuke Kitazawa,
Hisashige Kanbara, Taihei Odagiri, Katsuya Endo, Tatsuya Matsunaga, Seita Nakamura, Satomi Yagi, Yukio
Sato, Detection of circulating tumor cells in patients with lung cancer using metallic micro-cavity array filter:
A pilot study, Molecular and clinical oncology,12(3),278-283,2019-3
41) Shimizu H, Endo S, Natsugoe S, Doki Y, Hirata Y, Kobayashi J, Motomura N, Nakano K, Nishida H, Okada
M, Saiki Y, Saito A, Sato Y, Tanemoto K, Toh Y, Tsukihara H, Wakui S, Yokomise H, Masuda M, Yokoi K,
Okita Y. Thoracic and cardiovascular surgery in Japan in 2016 : Annual report by The Japanese Association
for Thoracic Surgery, General thoracic and cardiovascular surgery,67(4),377-411,2019.4
42) Yamaoka M, Maki N, Wijesinghe A, Sato S, Yanagihara T, Kobayashi N, Kikuchi S, Goto Y, Taguchi T, Sato Y.
Novel Alaska Pollock Gelatin Sealant Shows High Adhesive Quality andConformability. TheAnnals of thoracic surgery. Epub.2019.01.
DOI: 10.1016/j.athoracsur.2018.11.074
43) Goto Y, Hiramatsu Y, Ageyama N, Sato S, Mathis B J, Kitazawa S, Matsubara M, Sakamoto H, Sato Y. Rolipram plus
Sivelestat inhibits bone marrow-derived leukocytic lung recruitment after cardiopulmonary bypass in a primate model.
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 22(1).44-52.2018.10.
DOI: 10.1007/s10047-018-1071-0
44) Kobayashi N, Kobayashi K, Kikuchi S, Goto Y, Ichimura H, Endo K,Sato Y. Long-term pulmonary function after
surgery for lung cancer. Interactive CardioVascular and Thoracic Surgery. 24(5). 727-732. 2017.05 DOI:
10.1093/icvts/ivw414

45) Kobayashi K, Saeki Y, Kitazawa S, Kobayashi N, Kikuchi S, Goto S, Sakai M, Sato Y. Three-dimensional computed
tomographic volumetry precisely predicts the postoperative pulmonary function. Surg Today. 47(11). 1301-1311.
2017.04. DOI: 10.1007/s00595-017-1505-y46) Maki N, Takahashi H, Nakata T, Wakayama S, Hasegawa D, Sakamoto H, Fujita Y, Takata Y, Sukada T, Sato Y,
Yanagi H. The effect of respiratory rehabilitation for the frail elderly: a pilot study. Journal of General and Family
Medicine. 17(4). 289-298. 2016.12
47) Goto Y,Hiramatsu Y,Ageyama N,Sato S,Kanemoto S,Sato Y,Sakakibara Y. Cardiopulmonary bypass induces
recruitment of bone marrow-derived leukocytes to the lungs in monkeys.
Ann Thorac Surg. 97(2).617-622. 2014.02. DOI: 10.1016/j.athoracsur.2013.10.072
48) Usui S,Minami Y,Siosawa T,Iyama S,Satomi K,Sakashita S,SatoY,Noguchi M. Differences in the prognostic
implications of vascular invasion between lung adenocarcinoma and squamous cell carcinoma. Lung Cancer.82(3).
407-412. 2013.12. DOI: 10.1016/j.lungcan.2013.09.001
49) Kikuchi S. Iwai M. Sakurai-Yageta M. Tsuboi Y. Ito T. Maruyama T. Tsuda H. Kanai Y. Onizuka M. Sato Y.
Murakami Y. Expression of a splicing variant of the CADM1 specific to small cell lung cancer. Cancer Science.
103(6). 1051-1057. 2012.06.
DOI: 10.1111/j.1349-7006.2012.02277.x50) Kobayashi N. Usui S. Kikuchi S. Goto Y. Sakai M. Onizuka M. Sato Y. Preoperative lymphocyte count is anindependent prognostic factor in node-negative non-small cell lung cancer.
Lung Cancer. 75(2). 223-227. 2012.02. DOI: 10.1016/j.lungcan.2011.06.009
51) Sato Y, Tezuka Y, Kanai Y, Otani S, Yamamoto S, Tetsuka K, Sohara Y. Novel retractor for lymph node dissection byvideo-assisted thoracic surgery. Ann Thorac Surg.86(3). 1036-37. 2008.09. DOI: 10.1016/j.athoracsur.2008.04.002
52) Sato Y, Hiramatsu Y, Homma S, Sato M, Sato S, Endo S, Sohara Y. Phosphodiesterase type 4 inhibitor rolipram
inhibits activation of monocytes during extracorporeal circulation.
J Thorac Cardiovasc Surg.130(2). 346-350. 2005.08. DOI: 10.1016/j.jtcvs.2004.12.028
53) Sakai M, Sato Y, Sato S, Ihara S, Onizuka M, Sakakibara Y, Takahashi H. Effect of relocating to areas of reduced
atmospheric particulate matter levels on the human circulating leukocyte count.
J Appl Physiol. 97(5). 1774-80. 2004.11. DOI: 10.1152/japplphysiol.00024.2004
54) Sato Y, Hiramatsu Y, Homma S, Sato S, Onizuka M, Sakakibara Y. Phosphodiesterase type 4 inhibition of activatedpolymorphonuclear leukocytes in a simulated extracorporeal circulation model. J Thorac Cardiovasc Surg.125(1).
172-177. 2003.01. DOI: 10.1067/mtc.2003.98
55) Sato Y, Goto Y, Sato S, Endo S, Sohara Y. Continuous subcutaneous injection reduces polymorphonuclear leukocyte
activation by granulocyte colony-stimulating factor.
Am J Physiol Lung Cell Mol Physiol. 286(1).L143-148.2004.01.
DOI: 10.1152/ajplung.00248.2003
56) Sato Y, Modulation of PMN-endothelial cells interactions by cyclic nucleotides. Curr Pharm Des
10(2). 163-170. 2004.01
57) Sato Y, Sato S, Yamamoto T, Ishikawa S, Onizuka M, Sakakibara Y. Phosphodiesterase type 4 inhibitor reduces theretention of polymorphonuclear leukocytes in the lung. Am J Physiol Lung Cell Mol Physiol. 282(6). L1376-81.
2002.01. DOI: 10.1152/ajplung.00433.2001
58) Sato Y, Hogg JC, English D, van Eeden SF. Endothelin-1 changes polymorphonuclear leukocytes' deformability andCD11b expression and promotes their retention in the lung.
Am J Respir Cell Mol Biol. 23(3). 404-410. 2000.09. DOI: 10.1165/ajrcmb.23.3.4057
59) Sato Y, Walley KR, Klut ME, English D, D'yachkova Y, Hogg JC, van Eeden SF. Nitric oxide reduces thesequestration of polymorphonuclear leukocytes in lung by changing deformability and CD18
expression. Am J Respir Crit Care Med. 159(5 Pt 1) 1469-76. 1999.05. DOI:
10.1164/ajrccm.159.5.9808063
60) Sato Y, van Eeden SF, English D, Hogg JC. Bacteremic pneumococcal pneumonia: bone marrow release andpulmonary sequestration of neutrophils. Crit Care Med. 26(3) 501-509. 1998.05
61) Sato Y, Van Eeden SF, English D, Hogg JC. Pulmonary sequestration of polymorphonuclear leukocytes released

from bone marrow in bacteremic infection. Am J Physiol. 275(2). L255-261
1998.08. DOI: 10.1152/ajplung.1998.275. 2L255