Raw material exclusively for cosmetic manufacturing

Tilapia Atelocollagen HMarine-derived Cosmetic Material

SOLUBLE COLLAGEN

Fish atelocollagen for high-concentration use!!

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This product is a natural marine

Naturalatelocollagen extracted from the scales of
the tilapia.

Extracted by alkali treatment, thisClear

atelocollagen is very transparent when
dissolved in a neutral solution, and can beused in a variety of cosmetic products
including skin lotions and beauty essences.
Applications:skin lotions, beauty essences, creams, etc.

Characteristics

Moisturizing eﬀect

Triple-helical collagen with hydrophilicamino acids arranged on the molecularsurface.

Marine collagen highly
soluble in neutral andbasic solutions

Tilapia Atelocollagen H
Denaturation temperatureof Atelocollagen H

Diagram of moleculeCollagen(Native collagen)
CONH 2NH 2

COOH
N-telopeptide

NH 2

COOH

Triple-helical area

C-telopeptide

COOH

Speciﬁc optical rotation [α]DNH 2112

Tilapia Atelocollagen HAtelocollagen HNH 2

Triple-helical area

Alkalitreatment

Denaturation
temperature ofTilapia Atelocollagen H
Approximately30°C

Obtained by alkali treatment, Atelocollagen H is a collagen with a triple-helical structure from which antigenic
Temperature [°C]sites (telopeptides) have been removed. It is a marine pro-

Tilapia Atelocollagen H is a soluble collagen with a dena-tein with hydrophilic amino acids arranged on the mo-turation temperature of approximately 30°C.

lecular surface, and has a strong moisturizing eﬀect.

From in-house dataRelationship between solubility and pH
Solubility of atelocollagen
1.0

Product nameTilapia
Atelocollagen H

Turbidity

0.80.6isoelectric
point (pl)Acidsolution

Neutralsolution

Basicsolution

5.1

△○

○

Tilapia Atelocollagen H is a collagen that is highly soluble in the pH

0.4

range at or above 6 and at or below 4. When used in neutral skin0.2
0.0

lotions or beauty essences, it is less likely to become turbid or forma precipitate, and can be used in a wide range of formulations.
2345678910 11 12 13pHIn gels, creams and other semitransparent or opaque products,
it can be used as a moisturizing substance regardless of pH value.
From in-house data

Safety evaluation

Human repeated insult patch test (HRIPT): Negative

Product No. Product name

INCI name/中文名称

Other components

Package

ATH-121
ATH-221

SOLUBLE COLLAGEN
可溶性胶原DISODIUM PHOSPHATE, POTASSIUM PHOSPHATE,WATER, AND PHENOXYETHANOL

1kg
1kg

Tilapia Atelocollagen H 0.3% PE
Tilapia Atelocollagen H 1% PE.
The content in this document is prepared based on documents and experimental data available at the time; however, the content does not comprise a quarantee. Please note in advance that thecontent described in this document may be changed depending on the circumstances.All intellectual property rights including copyrights and design rights of data described here and related
documents belong to Koken Co., Ltd., and any unauthorized reproduction, reprinting or citation is strictly prohibited. Please refer to the MSDS of the product in advance for the safe use of theseingredients. In addition, care should be taken to comply with the laws and regulations related to the Pharmaceutical Aﬀairs Law in each country on expressions concerning consumer products.

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