PressOnline ISSN 2433-2070

SIOPSpecial Issue
Vol.8

News Letter

JCCG is an NPO that has gathered medical professionals
from all over the country to save children of chidhood cancer.

© Kato Yuko

To children with cancer

No. 8Issue date: November 16, 2018
Issued by: NPO Japan Children'sCancer GroupOur mission is to①Save lives②Provide support③Give hope for the future
Japan Children's Cancer Group (JCCG) is a group that researches and develops the treatment of cancer
for children. Medical professionals specializing in childhood cancer gathered and formed JCCG in 2014.
Approximately 200 institutions (mainly hospitals) are participating in JCCG. Many medical professionals,
mainly doctors of each facility, are engaged in therapeutic research as JCCG.

①Save lives
There are many types of cancer in children with different
characteristics from adults. Unfortunately, some children
lose their lives due to childhood cancer. We will develop
treatments for various childhood cancers to improvesurvival rate and reduce adverse effects.

②Provide support
It is necessary to follow-up these children because cancer
treatments are harsh, and even after treatments, childrenmay have poor physical condition, and anxiety. We keep
watching the long life of our children.

③Give hope for the future
Cause of cancer is often different from that of adultcancer, and cutting-edge research such as genetic analysis
is Cause of cancer is often different from that of adultcancer, and cutting-edge research such as genetic analysis
is necessary. We have constructed a system that collects
information from all over the country and examines
treatments by experts and a system to store and sharepatient data and specimens. JCCG is like one big hospital
specialized for childhood cancer. We will conduct cuttingedge diagnosis and treatments at All Japan and promoteresearches leading to better treatments.

◆Professional committee andspecial conference to promote research※ Chairman◆ Pathology Diagnostic Committee
Pathology
DiagnosticCommittee※◆ Atsuko
Nakazawa(Saitama
Prefectural
Pediatric
MedicalCenter) (Saitama※ Atsuko
Nakazawa◆ Image Diagnostic Committee
Pediatric
MedicalCenter)※Prefectural
Osamu Miyazaki(NationalCenterfor Child
Healthand Development)◆ Image
Diagnostic Committee◆ Surgical Therapy Committee※ Miyajuji(Nationalfor ChildTomoakiTaguchi(Kyushu CenterUniversity)◆HealthHematopoietic
Cell Transplant Committeeand Development)※ Koji Kato (Nagoya Daiichi Red Cross Hospital)◆ Surgical
Therapy
Committee◆Radiation
Therapy
Committee※Eiichi
Masaki (KamedaGeneral Hospital)
Tomoaki◆Long
termTaguchi
follow-up(Kyushu
committeeUniversity)※Miho
Maeda (Nippon
Medical School◆ Hematopoietic
Cell Transplant
Attached Hospital)
Committeetherapy committee◆Supportive※※ Fukushima
Keitaro Daiichi(DokkyoRedMedical
Koji Kato (NagoyaUniversity Hospital)

Cross Hospital)◆MolecularDiagnostic
Commission◆Radiation
Therapy
Committee※Tomohiko Taki (Kyorin University)※Eiichi Masaki (Kameda General◆ Biostatistics Committee※AkikoKada (NagoyaMedicalCenter)
Hospital)◆
Pathology
Diagnostic◆ Genome Medical Promotion CoreCommittee
Members Meeting※※ShukiMizutani(JCCG President)
AtsukoNakazawa(Saitama
JCCG PressPediatricNovember 16,
2018（No.8）
PrefecturalMedicalCenter)◆ Image Diagnostic Committee

Central image diagnostic system ～Significance, current situation of use～
Image Diagnostic Committee
Upload Business Performance Report
April 2016 to September 2018
Cumulative 225 reports in 109 cases
Ewing’s sarcoma: 6
Hepatoblastoma: 52Wilms tumor: 2
Neuroblastoma: 23
Germ cell tumor: 1
Brain tumors: 9
Rhabdomyosarcoma: 16

Cumulative 225(April 2016 to October 2018)

JCCG carries out the common treatments called clinical trials and we do our utmost to treat patients. At
that time, it is essential to judge the degree of progress of the disease before starting therapy and thetreatment effect after the start of treatment. One of the judgment methods is medical image diagnosis
such as ultrasound,CT, and MRI. By accurately interpreting these images, we will guide each child's東北大学病院
cancer to healing. Diagnostic imaging of each child is conducted at each medical institution in various
cities and judgment is made by radiologists, pediatricians, and pediatric surgeons at each institution.
The images mailed from all over the country will be uploaded to the central cloud computer system of
JCCG and the radiation specialists will evaluate the tumors on the image via the internet. In addition,
this system is a very convenient system that pediatricians and pediatric surgeons can access to discuss
the treatment effect of the patient, the possibility of surgery, the necessity of radiotherapy, etc.
For interpreting images of childhood cancer, higher expertise is required to be familiar with points tolook at and international classifications of childhood cancer. The JCCG imaging diagnostic committee isengaged by 17 radiation diagnostic specialists selected from childhood hospitals and university hospitals
nationwide. These members are expert group specializing in image diagnosis of children on a daily basis.
The central judgment of the image will be an interpretation report, and it will be delivered to theresponsible physicians and treatment committees of each disease.
At each hospital conference, the discussion is deepened with reference to the central judgment of theimage.

Active conferences

Tohoku University～Everyone thinks about what's best for the child～②Childhood Cancer General Conference

Sharing information on the pathology

of children with cancer and discuss①Pediatric Oncology Conference (POC)
Diagnosis of childhood cancer patients among physicians in related how they cope with mental and socialproblems. (pediatrician, nurse, in-classdepartments, determination of treatment and report on progress
小児科准教授teacher, nursery, clinicalpsychologist,(pediatrician, pediatric surgeon, orthopedic surgeon, radiologist)
笹原
medical social worker, CLS) 洋二 医師
JCCGPress
Press2018
November
JCCG
年 6 月16,20 2018（No.8）
日（第 6 号）

for learning support
We are close to children MeetVolunteer
the needs of learning for high school students in hospital
JCCG is building a support system so that children in hospital can better spend
their time.
In Tohoku University, one of childhood cancer core hospitals, third andfourth graders at the same university medical school teach studies for highschool students who are in hospital for a long time.
A high school girl who was learning English grammar said, "Even if I am
hospitalized, it is better to study than to do nothing. And I am relieved that
medical students teach me the tasks that my friends engage at school.
Because the medical student's age is close, it is easy to talk and it's fun to chat between studies. "Volunteers supporting high school students inTohoku University College of Medicine
Wearing matching scrub (medical wear with shortsleeve and neck origin as V neck). They consulted
with their colleagues and chose the rabbit pattern sothat the children do not feel a sense of oppression.

Comments by volunteers
We are always surprised by the desire of children'want to learn'. Because they are hospitalized,
there are waves in their physical condition. "I'msick today, I will do it in a short time "," Let's
wear a gown securely for prevention of infection ",etc. They will try not to postpone classes at anytime, somehow ingenuity and learning. They also
positively ask questions. "I wonder if there wereno opportunities for questions without this kind ofactivity", I feel the significance of the activities.
We are not yet licensed doctors. We are not theirrelatives. Still speaking with the patient, we canunderstand each other.

Everybody's Lemonade Party

When Shiro is active, friends
and adult volunteers are coming.
They are proponent of Shiro's
compassion for his friends.

Know more about childhood cancer through activities with friends
Shiro Eishima (11 year old), president of "Everyone's Lemonade Party".
Photo right. He had a brain tumor at the age of 4. He set up this party inorder to support his colleagues who are on treatment or who are notenergetic even after treatment. The main activity is to open a lemonade
stand.
"In order to develop newtreatments and medicines, it isnecessary to obtain money andsupport from many people." "Leteveryone get well." The children
themselves are discussing themeaning and contents of activities.

Halloween event of team 'Chan'

Connecting "thoughtfulness" to deceased friends
There is a group that raises funds for new medicines
effective for children's cancer in Tokorozawa City
every year at the Halloween season. Team "Chan".
The nickname of Senri Kiyokawa who made an
eternal sleep with osteosarcoma in 2010 is "Chan".
Nine years have passed since their irreplaceble
Chan's departure, and Chan's friends continue theirenlightenment activities.
She was 13 years They are considering a gentle and aggressive
old. She was active "Chan" and are seriously appealing to childhood
as a cheerleader. cancer support. It is a unique Halloween event in theworld.
JCCG Press November 16, 2018（No.8）

Recent publications of JCCG
1) Koh K, et al. Phase II/III study in children and adolescents with newly diagnosed B-cell precursor acutelymphoblastic leukemia: protocol for a nationwide multicenter trial in Japan. Jpn J Clin Oncol. 2018;
48:684-691.
2) Moriyama T, et al. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nat
Genet. 2016; 48:367-73.
3) Shima H, et al. Distinct impact of imatinib on growth at prepubertal and pubertal ages of children withb
chronic myeloid leukemia. J Pediatr. 2011; 159:676-81.
4) Koh K, et al. Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL generearrangement-positive acute lymphoblastic leukemia. Leukemia. 2015;29:290-6
5) Hishiki T, et al. Results of a phase II trial for high-risk neuroblastoma treatment protocol JN-H-07: a reportfrom the Japan Childhood Cancer Group Neuroblastoma Committee (JNBSG). Int J Clin Oncol. 2018;
23:965-973.
6) Oue T, et al. Renal Tumor Committee of the Japanese Children’s Cancer Group. Anaplastic histology Wilms'tumors registered to the Japan Wilms' Tumor Study Group are less aggressive than that in the National
Wilms' Tumor Study 5. Pediatr Surg Int. 2016; 32:851-5.
7) Hiyama E, et al. Resectability and tumor response after preoperative chemotherapy in hepatoblastoma
treated by the Japanese Study Group for Pediatric Liver Tumor (JPLT)-2 protocol. J Pediatr Surg. 2016;
51:2053-2057.
8) Kurosawa H, et al. Sequential use of second-generation tyrosine kinase inhibitors following imatinib
therapy in pediatric chronic myeloid leukemia: A report from the Japanese Pediatric Leukemia/Lymphoma
Study Group. Pediatr Blood Cancer. 2018; 65:e27368.
9) Moritake H, et al. Outcome of relapsed core binding factor acute myeloid leukemia in children: A result
from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) AML-05R study. Pediatr BloodCancer. 2017 Oct; 64(10).
10) Koshinaga T, et al. Outcome of renal tumors registered in Japan Wilms Tumor Study-2 (JWiTS-2): A reportfrom the Japan Children's Cancer Group (JCCG). Pediatr Blood Cancer. 2018 Jul;65(7):e27056.
11) Morimoto A, et al. Hemophagocytic lymphohistiocytosis: Pathogenesis, diagnosis, and management.
Pediatr Int. 2016; 58:817-25.
12) Sakashita K, et al. Diagnosis and treatment of juvenile myelomonocytic leukemia. Pediatr Int. 2016;
58:681-90.
13) Hosoi H. Current status of treatment for pediatric rhabdomyosarcoma in the USA and Japan. Pediatr
Int. 2016; 58:81-7.
14) Taga T, et al. Acute myeloid leukemia in children: Current status and future directions. Pediatr Int.
2016; 58:71-80.

Please cooperate with the support of children with cancer.

Please send donations to :JCCG, Japan Children's Cancer Research Group is aclinical research group made up of pediatric oncologistsand experts across the country and is engaged in various
research activities aiming at developing better childhood
cancer treatment.
Your donation will be used for maintaining a "central
diagnostic system" that correctly diagnoses the disease,research for establishing treatments fordifficult diseases yet to be completed,
and long-term follow-up after treatment.

Post office · Postal savings bank Postaltransfer account symbol 00850 - 5 Accountnumber 153506 Subscriber's name NPO JCCG

The JCCG Office

http://jccg.jp
Donation via the Internet
Donate with credit card

460-0003 Nagoya Yusen Building 8F, 3 - 6 - 35 Nishiki ,Naka - ku, Nagoya - CityTEL : 052-734-2182

FAX : 052-734-2183

E-mail : friend@jccg.jp

Illustration: Kato Yuko (http://katoyuko.sakura.ne.jp/) Copywriting: Sawako Ishiguro
JCCG vending machine design: limited company Sadatomo Kawamura DesignPart of the sales ofbeverages will be
donated to JCCG

JCCG Press November 16, 2018（No.8）