小林医師 業績（当院に赴任する前の業績も含む）
2023 年 4 月 1 日現在

著書
変形性膝関節症. 今日の診断指針

第 7 版, 1566-8.

関節外科診療ファーストステップ. 2-9, 35-38, 258-266.
人工関節周囲感染診断の基本と鎮静化までの基本手術. OS NOW Instructions 24 膝関節の難治性病態に対する手術, 64-74.
TKA 後のスポーツ活動についての現状分析と今後の課題. 関節外科, 2012, 31(11): 43-8.
主訴からみる診察フローチャート. 膝. 関節外科, 2014, 33(4): 74-91.
高位脛骨骨切り術の実際. 整形外科看護, 2015, 20(2): 82-7.
PJI 治療 (一期的または二期的再置換術) ①TKA. 関節外科, 2015, 34(9): 53-60.
Femoral bowing 例に対するナビゲーションの有用性について. 関節外科, 2016, 35(9):949-55.
人工関節周囲感染対策における国際コンセンサス. 2016, 165-174.
人工膝関節全置換術. 整形外科看護, 2017, 22(7): 43-8.
足関節捻挫・靭帯損傷. 整形外科看護, 2018, 23(4): 49-52.

1論文発表（英文のみ）
Kobayashi H, Takeno M, Saito T, Takeda Y, Kirino Y, Noyori K, Hayashi T, Ueda A,Ishigatsubo Y: Regulatory role of heme oxygenase 1 in inflammation of rheumatoid arthritis.
Arthritis Rheum, 54(4): 1132-42, 2006.

Kobayashi H, Mahovlic D, Bauer TW; Feature Article: Interpreting and Avoiding Histologic
Artifacts in Hard-Tissue Research. J histotechnol, 29(4): 223-8, 2006.

Kobayashi H, Fujishiro T, Belkoff SM, Kobayashi N, Turner AS, Seim HB, Zitelli J, Hawkins
M, Bauer TW: Long- term evaluation of a calcium phosphate bone cement withcarboxymethyl cellulose in a vertebral defect model. J Biomed Mat Res A, 88(4): 880-8,2009.

Kobayashi H, Oethinger M, Tuohy MJ, Procop GW, Hall GS, Bauer TW. Improved Detectionof Biofilm-Formative Bacteria on Polymethylmethacrylate by Vortexing and Ultrasonication:a pilot study. Clin Orthop Rel Res, 467(5): 1360-4, 2009.

Kobayashi H, Oethinger M, Tuohy MJ, Hall GS, Bauer TW. Improving clinical significance ofPCR: use of propidium monoazide to distinguish viable from dead Staphylococcus aureus
and Staphylococcus epidermidis. J Orthop Res, 27(9): 1243-7, 2009.

Kobayashi H, Oethinger M, Tuohy MJ, Hall GS, Bauer TW. Unsuitable distinction between
viable and dead Staphylococcus aureus and Staphylococcus epidermidis by ethidium
bromide monoazide. Lett Appl Microbiol, 48(5): 633-8, 2009.

Kobayashi H, Oethinger M, Tuohy MJ, Procop GW, Hall GS, Bauer TW. Limiting
false-positive polymerase chain reaction results: detection of DNA and mRNA to differentiate
viable from dead bacteria. Diagn Microbiol Infect Dis, 64(4): 445-7, 2009.

Kobayashi H, Hall GS, Tuohy MJ, Knothe U, Procop GW, Bauer TW. Bilateral periprosthetic
joint infection caused by Salmonella enterica serotype Enteritidis, and identification ofSalmonella sp using molecular techniques. Int J Infect Dis, 13(6): e463-6, 2009.

Kobayashi H, Turner AS, Seim HB, Kawamoto T, Bauer TW. Evaluation of a silica-containing2

bone graft substitute in a vertebral defect model. J Biomed Mat Res A, 92(2): 596-603,2010.

Kobayashi H, Oethinger M, Tuohy MJ, Hall GS, Bauer TW. Distinction between intact andantibiotic-inactivated bacteria by real-time PCR after treatment with propidium monoazide. JOrthop Res, 28(9): 1245-51, 2010.

Kobayashi H, Akamatsu Y, Taki N, Ota H, Mitsugi N, Saito T. Spontaneous dislocation of amobile-bearing polyethylene insert after posterior-stabilized rotating platform total knee
arthroplasty: a case report. Knee, 18(6): 496-8, 2011.

Kobayashi H, Mitsugi N, Mochida Y, Taki N, Akamatsu Y, Aratake M, Ota H, Ishii K, Harigane
K, Ideno T, Saito T. Mid- term results of stryker scorpio plus mobile bearing total kneearthroplasty. Sports Med Arthrosc Rehabil Ther Technol, 4(1): 38, 2012.

Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Muramatsu S, Saito T.
The surgical epicondylar axis is a consistent reference of the distal femur in the coronal andaxial planes. Knee Surg Sports Traumatol Arthrosc, 22(12): 2947-53, 2014.

Kobayashi H, Aratake M, Akamatsu Y, Mitsugi N, Taki N, Saito T. Reproducibility of condylar
twist angle measurement using computed tomography and axial radiography of the distalfemur. Orthop Traumatol Surg Res, 100(8): 885-90, 2014.

Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Aratake M, Saito T. Is the surgicalepicondylar axis the center of rotation in the osteoarthritic knee? J Arthroplasty, 30(3):479-83, 2015.

Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Ishigatsubo R, Mitsuhashi S,
Kobayashi A, Aratake M, Saito T. The use of factor Xa inhibitors following opening-wedge
high tibial osteotomy for venous thromboembolism prophylaxis. Knee Surg Sports
Traumatol Arthrosc, 25(9): 2929-35, 2017.

Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Aratake M, Saito T. Influence ofcoronal bowing on the lower alignment and the positioning of component in navigation andconventional total knee arthroplasty. Orthop Traumatol Surg Res. 103(2): 251-6, 2017.

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Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Saito T. Radiographic and computed
tomographic evaluation of bone union after medial opening wedge high tibial osteotomy withfilling gap. Knee. 24(5): 1108-17, 2017.

Kobayashi H, Akamatsu Y, Kumagai K, Kusayama Y, Okuyama H, Hirotomi K, Shinohara K,Saito T. Edoxaban is effective in reducing the incidence of asymptomatic phlebographic
events following closed-wedge high tibial osteotomy. Orthop Traumatol Surg Res. 103(8):1193-6, 2017.

Kobayashi H, Saito S, Akamatsu Y, Kumagai K, Nejima S, Inaba Y. The relationshipbetween the ‘‘Fujisawa point’’ and anatomical femorotibial angle following simulated openwedge high tibial osteotomy. BMC Musculoskelet Disord. 23: 776, 2022.

Takeda Y, Takeno M, Iwasaki M, Kobayashi H, Kirino Y, Ueda A, Nagahama K, Aoki I,Ishigatsubo Y; Chemical induction of HO-1 suppresses lupus nephritis by reducing local
iNOS expression and synthesis of anti-dsDNA antibody. Clin Exp Immunol, 138, 237-44,2004

Kirino Y, Takeno M, Murakami S, Kobayashi M, Kobayashi H, Miura K, Ideguchi H, Ohno S,Ueda A, Ishigatsubo Y: Tumor necrosis factor alpha acceleration of inflammatory responses
by down-regulating heme oxygenase 1 in human peripheral monocytes. Arthritis Rheum,56(2): 464-75, 2007.
Fujishiro T, Bauer TW, Kobayashi N, Kobayashi H, Sunwoo MH, Seim HBⅢ, Turner AS:
Histological evaluation of an impacted bone graft substitute composed of a combination ofmineralized and demineralized allograft in a sheep vertebral bone defect. J Biomed Mater
Res A, 82(3): 538-44, 2007.

Kobayashi N, Procop GW, Krebs V, Kobayashi H, Bauer TW. Molecular Identification ofBacteria from Aseptically Loose Implants. Clin Orthop Rel Res, 466(7): 1716-25, 2008.

Oethinger M, Warner DK, Schindler SA, Kobayashi H, Bauer TW (4/5). Diagnosing
periprosthetic infection: false-positive intraoperative Gram stains. Clin Orthop Relat Res,469(4): 954-60, 2011.

Akamatsu Y, Mitsugi N, Mochida Y, Taki N, Kobayashi H, Takeuchi R, Saito T. Navigated4

opening wedge high tibial osteotomy improves intraoperative correction angle comparedwith conventional method. Knee Surg Sports Traumatol Arthrosc, 20(3): 586-93, 2012.

Akamatsu Y, Mitsugi N, Taki N, Kobayashi H, Saito T. Medial versus lateral condyle bonemineral density ratios in a cross-sectional study: a potential marker for medial knee
osteoarthritis severity. Arthritis Care Res, 64(7): 1036-45, 2012.

Akamatsu Y, Mitsugi N, Hayashi T, Kobayashi H, Saito T. Low bone mineral density is
associated with the onset of spontaneous osteonecrosis of the knee. Acta Orthop, 83(3):249-55, 2012.

Zmistowski B, Della Valle C, Bauer TW, Malizos KN, Alavi A, Bedair H, Booth RE, Choong P,Deirmengian C, Ehrlich GD, Gambir A, Huang R, Kissin Y, Kobayashi H, Kobayashi N,Krenn V, Drago L, Marston SB, Meermans G, Perez J, Ploegmakers JJ, Rosenberg A,Simpendorfer C, Thomas P, Tohtz S, Villafuerte JA, Wahl P, Wagenaar FC, Witzo E.
Diagnosis of periprosthetic joint infection. J Arthroplasty, 29(2 Suppl): 77-83, 2014.

Zmistowski B, Della Valle C, Bauer TW, Malizos KN, Alavi A, Bedair H, Booth RE, Choong P,
Deirmengian C, Ehrlich GD, Gambir A, Huang R, Kissin Y, Kobayashi H, Kobayashi N,Krenn V, Lorenzo D, Marston SB, Meermans G, Perez J, Ploegmakers JJ, Rosenberg A, C
Simpfendorfer, Thomas P, Tohtz S, Villafuerte JA, Wahl P, Wagenaar FC, Witzo E.
Diagnosis of periprosthetic joint infection. J Orthop Res, 32(1 Suppl): 98-107, 2014.

Saito T, Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y. Five-to ten-year outcome
following medial opening-wedge high tibial osteotomy with rigid plate fixation in combination
with an artificial bone substitute. Bone Joint J, 96-B(3): 339-44, 2014.

Kusayama Y, Akamatsu Y, Kumagai K, Kobayashi H, Aratake M, Saito T. Changes insynovial fluid biomarkers and clinical efficacy of intra-articular injections of hyaluronic acidfor patients with knee osteoarthritis. J Exp Orthop, 1(1): 16, 2014.

Akamatsu Y, Kobayashi H, Kusayama Y, Aratake M, Kumagai K, Saito T. Predictive factors
for the progression of spontaneous of the knee. Knee Surg Sports Traumatol Arthrosc,25(2): 477-84, 2017.

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Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y, Koshino T, Saito T. Factors affecting
cartilage repair after medial opening-wedge high tibial osteotomy. Knee Surg Sports
Traumatol Arthrosc. 25(3): 779-84, 2017.

Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Comparative Study ofOpening-Wedge High Tibial Osteotomy With and Without a Combined Computed
Tomography-Based and Image-Free Navigation System. Arthroscopy. 32(10): 2072-81,
2016.

Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Femoral shaft bowing in thecoronal and sagittal planes on reconstructed computed tomography in women with medialcompartment knee osteoarthritis: a comparison with radiograph and its predictive factors.
Arch Orthop Trauma Surg. 136(9):1227-32,2016.

Akamatsu Y, Sotozawa M, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Usefulness oflong tibial axis to measure medial tibial slope for opening wedge high tibial osteotomy. KneeSurg Sports Traumatol Arthrosc. 24(11):3661-7, 2016.

Akamatsu Y, Ohno S, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Coronal subluxationof the proximal tibia relative to the distal femur after opening wedge high tibial osteotomy.
Knee. 24(1): 70-5, 2017.

Kumagai K, Akamatsu Y, Kobayashi H, Kusayama Y, Saito T. Mosaic Osteochondral
Autograft Transplantation Versus Bone Marrow Stimulation Technique as a ConcomitantProcedure with Opening-Wedge High Tibial Osteotomy for Spontanious Osteonecrosis of
the Medial Femoral Condyle. Arthroscopy. 34(1): 233-40, 2018.

Mitsuhashi S, Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Combined
CT-based and image-free navigation systems in TKA reduces postoperative outliers ofrotational alignment of the tibial component. Arch Orthop Trauma Surg. 138(2): 259-66,
2018.

Akamatsu Y, Kobayashi H, Kusayama Y, Kumagai K, Saito T. Opening Wedge High Tibial
Osteotomy Using Combined Computed Tomography-Based and Image-Free Navigation
System. Arthrosc Tech. 6(4): e1145-51, 2017.

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Akamatsu Y, Kumagai K, Kobayashi H, Tsuji M, Saito T. Effect of Increased Coronal
Inclination of the Tibial Plateau After Opening-Wedge High Tibial Osteotomy. Arthroscopy.
34(7): 2158-69, 2018.

Akamatsu Y, Kobayashi H, Tsuji M, Nejima S, Kumagai K, Saito T. Should sagittal osteotomyline be parallel to tibial posterior slope in high tibial osteotomy? BMC Musculoskelet Disord.
19(1): 338, 2018.

Tsuji M, Akamatsu Y, Kobayashi H, Mitsugi N, Inaba Y, Saito T. Joint line convergence angle
predicts outliers of coronal alignment in navigated open-wedge high tibial osteotomy. ArchOrthop Trauma Surg. 140(6): 707-15, 2020.

Nejima S, Akamatsu Y, Kobayashi H, Tsuji M, Mitsuhashi S, Sasaki T, Kumagai K, Inaba Y.
Relationship between lower limb torsion and coronal morphologies of the femur and tibia inpatients with medial knee osteoarthritis. BMC Musculoskelet Disord. 21(1): 254, 2020.

Nejima S, Kumagai K, Kobayashi H, Yamada S, Akamatsu T, Ogino T, Sotozawa M, Inaba Y.
Varus inclination of the tibia is related to patellofemoral osteoarthritis in Japanese female
patients with moderate knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 29(2):652-58, 2021.

Nejima S, Kumagai K, Kobayashi H, Yamada S, Akamatsu T, Ogino T, Sotozawa M, Inaba Y.
Coronal shaft bowing of the femur affects varus inclination of the surgical transepicondylaraxis in varus knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 29(3): 814-9, 2021.

Sasaki T, Akamatsu Y, Kobayashi H, Mitsuhashi S, Nejima S, Kumagai K, Saito T, Inaba Y.
Rotational changes in the distal tibial fragment relative to the proximal tibial fragment at theosteotomy site after ope-wedge high tibial osteotomy. Biomed Res Int. In press 2021.

Akamatsu Y, Nejima S, Tsuji M, Kobayashi H, Muramatsu S. Open-wedge high tibial
osteotomy using intraoperative control of joint line convergence angle with reference topreoperative supine radiograph. Arch Orthop Trauma Surg 2021, 141(4): 645-53.

Akamatsu Y, Nejima S, Tsuji M, Kobayashi H, Muramatsu S. Joint line obliquity wasmaintained after double-level osteotomy, but was increased after open-wedge high tibial
osteotomy. Knee Surg Sports Traumatol Arthrosc. 30(2): 688-97, 2021.
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Nejima S, Kumagai K, Kobayashi H, Fujimaki H, Yamada S, Sotozawa M, Hisatomi K, Inaba
Y. Medialization of the mechanical axis of the tibia is related to lateralization of the tibial
tuberosity in knee osteoarthritis. Knee. 30: 134-40, 2021.

Akamatsu Y, Kobayashi H, Nejima S, Schroter S. Can double-level osteotomy prevent
patellofemoral osteoarthritis progression compared with open wedge high tibial osteotomy?
Arch Orthop Trauma Surg. 143(4): 2073-85, 2023.

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