㫽ྲྀ┴⏘ᴗᢏ⾡ࢭࣥࢱ࣮◊✲ሗ࿌ No.19 (2016)㫽ྲྀ┴ෆ࡛ᤕ⋓ࡉࢀࡓࢪࣅ࢚⫗ࡢᡂศ࡜ࡑࡢရ㉁㸦➨  ሗ㸧Components and Quality of Gibier Meats of Animals Captured in Tottori Prefecture (1st Report)࣍ࣥࢩࣗ࢘ࢪ࢝⫗ࡢᡂศ࡜ࡑࡢရ㉁
Nutritional Properties and Quality of the Meat of Cervus Nipponn Centralis                 ୰㔝 㝧 ࣭ᮏከ⨾ᜨ ࣭⩚⏣㔝⪽⨾ ࣭ᱵᯘᚿᾈ ࣭▮㔝ཎὈኈ࣭ᑠ㇂ᖾᩄ



Hiroshi Nakano, Mie Honda, Satomi Hatano, Yukihiro Umebayashi, Taishi Yanohara and Yukitoshi Kodani*௻⏬࣭㐃ᦠ᥎㐍㒊 ௻⏬ᐊࠊ**㣗ရ㛤Ⓨ◊✲ᡤ 㣗ရ㛤Ⓨ⛉ࠊ***㣗ရ㛤Ⓨ◊✲ᡤ ࣂ࢖࢜ᢏ⾡⛉ࠊ****㣗ရ㛤Ⓨ◊✲ᡤ ࢔ࢢࣜ㣗ရ⛉ࠊ*****㣗ရ㛤Ⓨ◊✲ᡤ㫽ྲྀ┴ෆ࡛ᤕ⋓ࡉࢀࡓ࣍ࣥࢩࣗ࢘ࢪ࢝㸦Cervus Nipponn Centralis㸧ࡢ⫗ࡢᡂศ࡜ࡑࡢရ㉁ࢆㄪᰝࡋࡓࠋࢩ࢝⫗ࡣ∵࣭㇜࡜ẚ㍑ࡋ࡚⬡㉁ྵ᭷㔞ࡀᴟࡵ࡚ᑡ࡞ࡃࠊ⬡⫫㓟⤌ᡂ࡛ࡣࠊከ౯୙㣬࿴⬡⫫㓟ྵ᭷⋡ࡀ㧗࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋࡲࡓࠊ࢔ࣥࢭࣜࣥࠊ࢝ࣝࣀࢩࣥࠊL-࢝ࣝࢽࢳࣥࡀẚ㍑ⓗከࡃྵࡲࢀ࡚࠸ࡿ࡜࠸࠺≉ᚩࢆ᭷ࡋ࡚࠸ࡓࠋࢩ࢝⫗ࡢရ㉁࡟ࡘ࠸࡚ࡣࠊᤕ⋓ᚋෆ⮚᦬ฟࡲ࡛㸲᫬㛫⤒㐣ࡋࡓಶయࡢ࣮ࣟࢫ⫗ࡣࠊࢪ࢔ࢭࢳࣝࡀከࡃ᳨ฟࡉࢀࠊ࣡ࢼ࡛ᤕ⋓ࡉࢀࡓಶయࡣࠊ⫗ࡢຍᅽಖỈᛶࡀపୗࡋࠊpH ࡀ㧗ࡃရ㉁ⓗ࡟ຎࡿഴྥࡀぢࡽࢀࡓࠋThe components and quality of meat of Japanese deer (Cervus. Nipponn. Centralis) captured in Tottori Prefecture
were surveyed.

Analysis of the fatty acid composition revealed that the polyvalent unsaturated fatty acid content inthese meats was high.

They were also characterized and found to contain anserine, carnosine, and L- carnitine in

relatively high amounts.

Concerning the deer meat quality, diacetyl was abundantly detected in the loins of animals

when 4 hours had passed from capture to organ removal.

Moreover, the pressurized water holding property of themeat was reduced, pH was high, and the quality tended to be inferior for meats of animals that were caught in a trap.

 ࡣࡌࡵ࡟㏆ᖺࠊࢩ࢝ࡸ࢖ࣀࢩࢩࡢ㎰ᯘᴗ⿕ᐖࡀቑຍࡋ࡚

ࡽ࡟ࠊ⌧ᅾࠊ฼⏝ࡉࢀ࡚࠸ࡿ㒊఩ࡣ࣮ࣟࢫࡀ࡯࡜

࠾ࡾࠊ㫽ྲྀ┴࡞࡝ࡢᤕ⋓ᨭ᥼➼࡟ࡼࡾࠊ┴ෆࢩ࢝ࢇ࡝࡛࠶ࡿࡀࠊ௚ࡢ㒊఩ࡢ᭷ຠ฼⏝ࡶᮃࡲࢀ࡚࠸

ࡣ 3,000 㢌ࠊ࢖ࣀࢩࢩࡣ 4,700 㢌ࢆ㉸࠼ࡿಶయࡀ 1ࡿࠋ࣮ࣟࢫ௨እࡢ㒊఩⫗ࡢ≉ᚩࡀศ࠿ࢀࡤࠊ㣗⏝ᖺ㛫࡟ᤕ⋓ࡉࢀ࡚࠸ࡿ㸯㸧ࠋࡇࢀࡲ࡛ᤕ⋓ࡉࢀ࡚ࡁ㈨※ࡢ᭷ຠ฼⏝࡟ࡘ࡞ࡀࡿࡔࡅ࡛࡞ࡃࠊᯞ⫗༢఩ࡓࢩ࢝ࡸ࢖ࣀࢩࢩ࡟ࡘ࠸࡚ࡣࠊࡑࡢ࡯࡜ࢇ࡝ࡀᗫ

࡛ࡢὶ㏻ࡶ⾜ࢃࢀࡿࡼ࠺࡟࡞ࡾࠊࢪࣅ࢚ࡢゎయฎᲠࡸ⮬ᐙ฼⏝ࡉࢀࡿ࡟␃ࡲࡗ࡚ࡁࡓࡀࠊ᭱㏆ࠊ୍⌮ࢆ⾜ࡗ࡚࠸ࡿ⊁⊟⪅ࡢ㒊ศ⫗ศูసᴗࡢ㈇ᢸ㒊ࡢᆅᇦ࡛⋇⫗㸦ࢪࣅ࢚㸧ࢆᆅᇦ㈨※࡜ࡋ࡚ά⏝㍍ῶ࡟ࡘ࡞ࡀࡿ࡜ᛮࢃࢀࡿࠋࡋࡼ࠺࡜࠸࠺άືࡀጞࡲࡗ࡚࠸ࡿࠋ㫽ྲྀ┴ࡢࢪࣅࡲࡓࠊࢪࣅ࢚ࡣ೺ᗣ㣗ᮦ࡜ࡋ࡚ࡶ▱ࡽࢀ࡚࠸ࡿ࢚ࡢᡂศྵ᭷㔞ࡸရ㉁➼࡟ࡘ࠸࡚ࠊ࡯࡜ࢇ࡝ࢹ࣮ࡀࠊ㫽ྲྀ┴ෆࡢࢪࣅ࢚ࡢ೺ᗣᶵ⬟ᛶᡂศ࡟㛵ࡍࡿࢱࡀ࡞࠸ࡇ࡜࠿ࡽࠊࢪࣅ࢚ࢆ᭷ຠ฼⏝ࡍࡿ㝿࡟ࡣࠊㄪᰝࡣࡉࢀ࡚࠾ࡽࡎࠊ೺ᗣ㣗ᮦ࡜ࡋ࡚ࡢ࢔ࣆ࣮ࣝࡇࢀࡽࢪࣅ࢚ࡢ≉ᚩ➼ࢆᢕᥱࡍࡿᚲせࡀ࠶ࡿࠋࡉ

࣏࢖ࣥࢺࢆ⾜ᨻࠊᾘ㈝⪅ࡼࡾồࡵࡽࢀ࡚࠸ࡿࠋ1ࡑࡇ࡛ࠊᮏሗ࡛ࡣ㫽ྲྀ┴ෆ࡛ᤕ⋓ࡉࢀࡓ࣍ࣥࢩⅣỈ໬≀㸸4.11 kcal/g㸧ࢆ஌ࡌ࡚ࣗ࢘ࢪ࢝ࡢ⫗ࡢᡂศศᯒ࠾ࡼࡧࡑࡢရ㉁ࢆㄪᰝ

᥮⟬ࡋࡓࠋࡋࡓࡢ࡛ࡑࡢ⤖ᯝࢆሗ࿌ࡍࡿࠋ࣭㕲ศ㸸┤᥋⅊໬ἲ࡛ᚓࡽࢀࡓ⅊ศࢆሷ㓟࡟ຍ⇕⁐ゎࡋࠊཎᏊ྾ගศගගᗘィ㸦㸦ᰴ㸧 ᐇ㦂᪉ἲᓥὠ〇సᡤ AA-6650F㸧࡛ᐃࡋࡓࠋ

 ౪ヨᮦᩱࢩ࢝⫗ࡢ⬡⫫㓟⤌ᡂ ᡂศศᯒ
ᖹᡂ 25 ᖺ 12 ᭶ࠊᖹᡂ 26 ᖺ 8 ᭶ࠊ12 ᭶࠾ࡼࡧࢡ࣒ࣟࣟ࣍ࣝ-࣓ࢱࣀ࣮ࣝΰྜᾮ㸦2:1(v/v)㸧࡛ᖹᡂ 27 ᖺ 2 ᭶࡟㫽ྲྀ┴ⱝᱜ⏫ෆ࡛ᤕ⋓ࡉࢀࡓࢩᢳฟࡋࡓࢩ࣮࢝ࣟࢫ⫗ࡢ⬡⫫ࢆࠊỈ㓟໬࣒࢝ࣜ࢘࢝ࡢ⫗ࢆ⏝࠸ࡓࠋࡇࡢ࠺ࡕࠊ෤Ꮨ࡜ኟᏘࡢᡂศẚ࣓ࢱࣀ࣮ࣝ⁐ᾮ࡛ຍỈศゎࡋࠊ୕ࣇࢵ໬࣍࢘⣲࣓㍑ࡣ࣮ࣟࢫ⫗ࢆ⏝࠸ࡓࠋࢱࣀ࣮ࣝ㘒య࡛࣓ࢳ࢚ࣝࢫࢸࣝ໬ࡋࡓᚋࠊ࢞ࢫࢡࡲࡓࠊ෤Ꮨ࠾ࡼࡧኟᏘ࡟࣡ࢼ࡛ᤕ⋓ࡉࢀࡓ᥎ᐃ

࣐ࣟࢺࢢࣛࣇ㉁㔞ศᯒ⿦⨨㸦㸦ᰴ㸧ᓥὠ〇సᡤᖺ㱋 3 ṓࡢ㞤ࠊྛ 1 㢌ࡢ⫗࡟ࡘ࠸࡚ࠊ㒊఩ูࡢᡂ

GCMS-QP2010 Plus㸧࡟ࡼࡾศᯒࡋࡓࠋศㄪᰝ࡟౪ࡋࡓࠋ࢔ࣥࢭࣜࣥࠊ࢝ࣝࣀࢩࣥࡢᐃ㔞 ⮯Ẽศᯒ㐣ሷ⣲㓟ᢳฟᾮ㸦5%㸧ࢆ඲⮬ື࢔࣑ࣀ㓟ศᯒィప฼⏝ࡀぢ㎸ࡲࢀ࡚࠸ࡿಶయࡸ㒊఩ࡢ⌧≧ࢆ

JLC500/V2㸦᪥ᮏ㟁Ꮚ㸦ᰴ㸧㸧ࢆ⏝࠸࡚ศูᐃ㔞ࡋᢕᥱࡍࡿࡓࡵ࡟ࠊᒕẅᚋ㏿ࡸ࠿࡟ෆ⮚ࢆ᦬ฟࡋࡓࡓࠋಶయ࡜ࠊෆ⮚᦬ฟࡲ࡛࡟ 4 ᫬㛫⤒㐣ࡋࡓಶయࡢࣟ/࢝ࣝࢽࢳࣥ࠾ࡼࡧ࢔ࢭࢳࣝ࢝ࣝࢽࢳࣥࡢ࣮ࢫ⫗ࢆ⏝࠸ࡓࠋᐃ㔞ྜྷᮧࡽ㸰㸧ࡀሗ࿌ࡋ࡚࠸ࡿ㧗㏿ᾮయࢡ࣐ࣟࢺࢢࣛ ᤕ⋓᪉ἲู⫗㉁ㄪᰝ
ᤕ⋓᪉ἲ㸦㖠ࠊ࣡ࢼ㸧ࡢ␗࡞ࡿ࢝ࢱ⫗࡟ࡘ࠸࡚ࣇ࢕࣮㸫㉁㔞ศᯒィ㸦LC-MS/MS㸧ࢆ⏝࠸ࡓᡭἲᤕ⋓᪉ἲู⫗㉁ㄪᰝࢆ⾜ࡗࡓࠋ࡟‽ࡌ࡚⾜ࡗࡓࠋศᯒࡣࠊࣁ࢖ࣈࣜࢵࢻᆺᾮయࢡ࣐ࣟࢺࢢࣛࣇ㉁㔞ศᯒィ㸦᪥ᮏ࢛࣮࢘ࢱ࣮ࢬ㸦ᰴ㸧 ⫗ࡢᡂศศᯒACQUITY UPLC H-CLASS Xevo® G2-S Q-TOF㸧ࢆࢩ࢝⫗ࡢ୍⯡ᰤ㣴ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞ࡢ⏝࠸ࡓࠋㄪᰝ ⫗ࡢ⮯Ẽศᯒࢩ࢝⫗ࡢ୍⯡ᡂศศᯒ㸦Ỉศࠊ⬡㉁ࠊ⅊ศࠊࢱ㸦㸯㸧ᅛ┦࣐࢖ࢡࣟᢳฟἲ࡟ࡼࡿ᥹Ⓨᛶᡂศࡢᤕ㞟

ࣥࣃࢡ㉁ࠊⅣỈ໬≀ࠊ࢚ࢿࣝࢠ࣮㸧࠾ࡼࡧ㕲ࡢᐃࢩ࢝⫗ࢧࣥࣉࣝ㸦0.5 g㸧ࢆࢫࢡ࣮ࣜࣗ࢟ࣕࢵࣉ

㔞ࡣ௨ୗࡢ᪉ἲ࡛⾜ࡗࡓࠋ࣭Ỉศ㸸ᖖᅽຍ⇕஝⇱ἲ㸦135 Υ, 2 ᫬㛫㸧௜ࡁࣂ࢖࢔ࣝ⎼㸦10 mL㸧࡟᥇ྲྀࡋࠊ50 Υ࡛ 5 ศ࣭⬡㉁㸸ࢯࢵࢡࢫ࣮࣭࢚࣮ࣞࢸࣝᢳฟἲ㛫ຍ࣭⅊ศ㸸┤᥋⅊໬ἲ㸦550 Υ㸧ࡋࡓ SPME ࣇ࢓࢖ࣂ࣮㸦ࢩࢢ࣐࢔ࣝࢻࣜࢵࢳࢪࣕ

࣭ࢱࣥࣃࢡ㉁㸸ࢭ࣑࣑ࢡࣟࢤࣝࢲ࣮ࣝἲࣃࣥ㸧࡟ࡼࡾ࣊ࢵࢻࢫ࣮࣌ࢫ୰ࡢ᥹Ⓨᛶᡂศࢆ࣭ⅣỈ໬≀㸸ᕪࡋᘬࡁἲ

50 Υ࡛ 15 ศ㛫᥇㞟ࡋࡓࠋࡋࡓࠋḟ࡟ࠊDVB/CAR/PDMS ࢆ྾╔ᮦ࡜

㸦㸰㸧GC/MS ศᯒ࣭࢚ࢿࣝࢠ࣮㸸࢚ࢿࣝࢠ࣮᥮⟬ィᩘ㸦⬡㉁㸸9.41

ᤕ㞟ࡋࡓ᥹Ⓨᛶᡂศࢆ࢞ࢫࢡ࣐ࣟࢺࢢࣛࣇ㉁kcal/gࠊࢱࣥࣃࢡ㉁㸸4.22 kcal/g2ࢩ࢝⫗ࡢ୍⯡ᰤ㣴ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞ࡢ㔞ศᯒ⿦⨨㸦GC/MS-QP2010 Plus㸦㸦ᰴ㸧ᓥὠ〇సㄪᰝᡤ㸧࡟ࡼࡾศ㞳ᐃ㔞ࡋࡓࠋ࣒࢝ࣛࡣ DB-WAX ࣒࢝ࣛ㸦60 m  0.32 mm i.d. ⭷ཌ 0.5 ȣm, ࢔ࢪࣞ㫽ྲྀ┴ⱝᱜ⏫ෆ࡛ᤕ⋓ࡉࢀࡓࢩ࢝ࡢ࣮ࣟࢫ⫗ࣥࢺࢸࢡࣀࣟࢪ࣮ࢬ㸦ᰴ㸧㸧ࢆ⏝࠸ࡓࠋ࣒࢝ࣛ࡟ࡘ࠸࡚ࠊ୍⯡ᰤ㣴ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞ࢆㄪᰝࡋᗘࡣ 35 Υ࠿ࡽ 240 Υࡲ࡛ 10 Υ/min ࡛᪼ࡋࡓࡓ㸦⾲㸯㸧ࠋࡑࡢ⤖ᯝࠊࢩ࢝⫗ࡣ∵࣭㇜࡜࠸ࡗࡓ

ᚋࠊ240 Υ࡛ 10 ศ㛫ಖᣢࡋࠊ࢟ࣕࣜ࢔࢞ࢫ࡟ࡣ

௚ࡢ␆⫗㸲㸧࡜ẚ㍑ࡋ࡚ࠊࢱࣥࣃࢡ㉁➼ࡢᰤ㣴ᡂศ࣒࣊ࣜ࢘࢞ࢫࢆ⏝࠸ࡓࠋὀධཱྀᗘ 200 Υ, ࢖࢜࡟ᕪࡣぢࡽࢀ࡞࠸ࡶࡢࡢࠊ඲⯡ⓗ࡟⬡㉁ྵ᭷㔞ࡀࣥ໬㟁ᅽ 70 eV㸦EI㸧, ࢖࢜ࣥ※

ᗘ 200 Υ࡟࡚ࡁࢃࡵ࡚ᑡ࡞ࡃࠊỈศࡀከ࠸ഴྥࡀぢࡽࢀࡓࠋࡲศᯒࢆ⾜ࡗࡓࠋ࢞ࢫࢡ࣐ࣟࢺࢢࣛࣇ࡛ศ㞳ࡉࢀࡓࡓࠊ㫽ྲྀ┴⏘ཬࡧරᗜ┴⏘㸳㸧ࡢࢩ࢝⫗ࡣ㍺ධࢩ࢝

ᡂศࡢྠᐃࡣࠊSelection Ion Monitoring (SIM)ศᯒ

⫗㸴㸧ࡼࡾࡶࡉࡽ࡟⬡㉁ྵ᭷㔞ࡀᑡ࡞࠸ഴྥࡀぢࡽ࡟ࡼࡗ࡚ᚓࡽࢀࡓ㉁㔞ࢫ࣌ࢡࢺࣝ࡜ࡢẚ㍑ཬࡧ

ࢀࡓࠋࡇࡢ⌮⏤࡜ࡋ࡚ࡣࠊ㍺ධࢩ࢝⫗ࡣࠊ㣵ࢆ༑ࣛ ࢖ ࣈ ࣛ ࣜ ࣮ ࣜ ࢧ ࣮ ࢳ ࢩ ࢫ ࢸ ࣒ 㸦 NIST Massศ୚࠼ࡽࢀ࡚㣫⫱ࡉࢀࡓࡶࡢ࡛࠶ࡾࠊ㫽ྲྀ┴ࡸර

Spectra Data Base㸧࡟ࡼࡿ᳨⣴࡟ࡼࡾ⾜ࡗࡓࠋᗜ┴ࡢࢩ࢝⫗ࡣࠊ㣵ࡀ₶ἑ࡟ᚓࡽࢀࡿ⎔ቃ࡟ࡣ࡞࠸㔝⏕ࡢಶయ࡛࠶ࡿࡇ࡜ࡀࠊᙳ㡪ࡋࡓࡢ࡛ࡣ࡞࠸ ᤕ⋓᪉ἲู⫗㉁ㄪᰝ

࠿࡜⪃࠼ࡽࢀࡿࠋᏘ⠇ⓗ࡞ኚື࡟ࡘ࠸࡚ࡣࠊ୍⯡⊟㖠࡛ᤕ⋓ࡉࢀࡓಶయ࡜࣡ࢼ⊟࡛ࡢᤕ⋓ࡉࢀࡓಶయࡢ࢝ࢱ⫗ࡢຍᅽಖỈᛶ࡜ pH ࢆຍᅽಖỈᛶࡣᐃἲ㸱㸧࡟ᚑ࠸࡟ࢩ࢝ࡢ᪪ࡣኟᏘ࡛࠶ࡿ࡜࠸ࢃࢀ࡚࠸ࡿࡇ࡜࠿ᐃࡋࡓࠋᐃࡋࡓࠋpH ࡢࡽࠊ⬡㉁ྵ᭷㔞ࡣኟᏘࡢ᪉ࡀ㧗࠸ࡢ࡛ࡣ࡞࠸࠿࡜ᐃᛮࢃࢀࡓࡀࠊ௒ᅇࡢㄪᰝ࡛ࡣࠊᏘ⠇࡟ࡼࡿᕪࡣࡳ࡟ࡣ᥋ゐᘧ pH ࣓࣮ࢱ࣮㸦ࣛࢥ࣒ࢸࢫࢱ࣮ pHࡽࢀ࡞࠿ࡗࡓࠋ㕲ྵ᭷㔞࡟ࡘ࠸࡚ࡣࠊࢩ࢝⫗ࡣ௚ࡢ␆⫗࡜ẚ㍑Spear㸧ࢆ⏝࠸ࡓࠋࡋ࡚඲⯡ⓗ࡟ከ࠸ഴྥࡀ࠶ࡿࡀࠊ෤ᏘヨᩱࡣኟᏘ ⤖ᯝ࡜⪃ᐹヨᩱࡸරᗜ┴ࠊ㍺ධ⫗ࡼࡾከ࠸ഴྥࡀぢࡽࢀࡓࠋ ⫗ࡢᡂศศᯒ௒ᅇศᯒࡋࡓ෤Ꮨヨᩱࡢ୰࡟ࡣࠊ㕲ྵ᭷㔞ࡀ 100 g⾲㸯 㫽ྲྀ┴⏘ࢩ࣮࢝ࣟࢫ⫗ࡢ୍⯡ᰤ㣴ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞䜶䝛䝹䜼䞊㼗㼏㼍㼘㻛㻝㻜㻜㼓 㼗㻶㻛㻝㻜㻜㼓ヨᩱỈศ㼓㻛㻝㻜㻜㼓⬡㉁㼓㻛㻝㻜㻜㼓⅊ศ㼓㻛㻝㻜㻜㼓䝍䞁䝟䜽㉁㼓㻛㻝㻜㻜㼓ⅣỈ໬≀㼓㻛㻝㻜㻜㼓ኟᏘ䠄㼚㻩㻢䠅㻣㻡㻚㻢㻜㻚㻤㻝㻚㻝㻞㻝㻚㻡㻝㻚㻝㻝㻜㻟㻠㻟㻜㻟㻚㻞෤Ꮨ䠄㼚㻩㻠䠅㻣㻣㻚㻝㻝㻚㻜㻝㻚㻝㻞㻜㻚㻝㻜㻚㻤㻥㻣㻠㻜㻡㻠㻚㻜㻣㻣㻚㻤㻜㻚㻠㻝㻚㻝㻞㻜㻚㻢㻜㻚㻜㻤㻣㻟㻢㻞㻟㻚㻞㻣㻣㻚㻣㻜㻚㻥㻝㻚㻝㻞㻜㻚㻜㻜㻚㻟㻤㻥㻟㻣㻠㻟㻚㻟䠄㼎䠅㻣㻠㻚㻢㻝㻚㻡㻝㻚㻝㻞㻞㻚㻟㻜㻚㻡㻝㻝㻜㻠㻢㻜㻟㻚㻝䠄㼏䠅රᗜ┴⏘䝅䜹⫗䠄㼍䠅䠄䜸䝇䠅රᗜ┴⏘䝅䜹⫗䠄㼍䠅䠄䝯䝇䠅䝅䜹⫗㻡㻡㻚㻥㻞㻡㻚㻤㻜㻚㻤㻝㻣㻚㻝㻜㻚㻠㻟㻝㻣㻝㻘㻟㻞㻢㻞㻚㻜䠄䡀䠅㻣㻞㻚㻝㻠㻚㻠㻝㻚㻜㻞㻞㻚㻜㻜㻚㻡㻝㻟㻢㻡㻢㻥㻞㻚㻞䠄㼑䠅㻣㻜㻚㻟㻡㻚㻢㻝㻚㻝㻞㻞㻚㻣㻜㻚㻟㻝㻡㻜㻢㻞㻤㻜㻚㻣䠄㼒䠅㻣㻝㻚㻞㻠㻚㻢㻝㻚㻝㻞㻞㻚㻥㻜㻚㻞㻝㻠㻝㻡㻥㻜㻜㻚㻢࿴∵㍺ධ∵㕲㼙㼓㻛㻝㻜㻜㼓㇜኱ᆺ✀㇜୰ᆺ✀䠑䠅䠄㼍䠅ᖹᡂ㻞㻞ᖺ㻝㻞᭶䛻රᗜ┴୹Ἴᆅᇦ䛷ᤕ⋓䛥䜜䛯䝅䜹㻌㻌䠒䠅䠄㼎䠅䛒䛛䛧䛛㻌㍺ධ෭෾ရ㻌㉥⫗㻌⏕䠐䠅䠄㼏䠅䝃䞊䝻䜲䞁㻌㉥⫗㻌⏕㻌䠐䠅䠄㼐䠅䝃䞊䝻䜲䞁㻌㉥⫗㻌⏕㻌䠐䠅䠄㼑䠅㻌㉥⫗㻌⏕㻌䠐䠅䠄㼒䠅㻌㉥⫗㻌⏕㻌3⾲㸰 㫽ྲྀ┴⏘ࢩ࣮࢝ࣟࢫ࣭࣭ࣔࣔࣂࣛ⫗ࡢ୍⯡ᰤ㣴ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞 Q  Ꮨ⠇ኟ෤㒊఩䝻䞊䝇䝰䝰䝞䝷䝻䞊䝇䝰䝰䝞䝷Ỉศ㼓㻛㻝㻜㻜㼓㻣㻢㻚㻢㻣㻣㻚㻟㻣㻥㻚㻜㻣㻤㻚㻥㻣㻣㻚㻣㻣㻥㻚㻣⬡㉁㼓㻛㻝㻜㻜㼓㻜㻚㻥㻜㻚㻤㻝㻚㻢㻝㻚㻞㻜㻚㻣㻝㻚㻝⅊ศ㼓㻛㻝㻜㻜㼓㻝㻚㻝㻝㻚㻝㻜㻚㻥㻝㻚㻜㻝㻚㻝㻜㻚㻥䝍䞁䝟䜽㉁㼓㻛㻝㻜㻜㼓㻞㻝㻚㻤㻞㻜㻚㻢㻝㻤㻚㻢㻝㻤㻚㻣㻝㻥㻚㻢㻝㻣㻚㻟࠶ࡓࡾ 5.4 mg ྵࡲࢀ࡚࠸ࡿࡶࡢࡀ࠶ࡾࠊࡑࡢಶయⅣỈ໬≀㼓㻛㻝㻜㻜㼓㻜㻚㻜㻜㻚㻞㻜㻚㻜㻜㻚㻞㻜㻚㻥㻜㻚㻥䜶䝛䝹䜼䞊㼗㼏㼍㼘㻛㻝㻜㻜㼓㼗㻶㻛㻝㻜㻜㼓㻝㻜㻝㻠㻞㻞㻥㻢㻠㻜㻜㻥㻟㻟㻥㻜㻥㻝㻟㻤㻝㻥㻟㻟㻥㻝㻤㻣㻟㻢㻡㕲ศ㼙㼓㻛㻝㻜㻜㼓㻟㻚㻣㻠㻚㻞㻞㻚㻥㻟㻚㻡㻠㻚㻜㻞㻚㻤 ẚ㸧ࢆࡲ࡜ࡵࡓࡶࡢࢆ⾲㸱࡟♧ࡋࡓࠋࢆຍ⇕ࡋ࡚ヨ㣗ࡋࡓ࡜ࡇࢁࠊ㠀ᖖ࡟⏕⮯ࡃឤࡌࡽከ౯୙㣬࿴⬡⫫㓟ࡢ୰࡛ࡶࠊn-6 ⣔⬡⫫㓟ࡢ㐣ࢀࡓࡇ࡜࠿ࡽࠊ㕲ྵ᭷㔞ࡀ㧗࠸ࡶࡢࡣရ㉁ࡀຎࡿ

๫ᦤྲྀࡣ࢔ࣞࣝࢠ࣮࡞࡝ࡢ⅖⑕ࡢ༴㝤ᛶࡀ࠶ࡿྍ⬟ᛶࡀ࠶ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋヨᩱࡢᤕ⋓᪉ἲࡢ࡜࠸ࢃࢀ࡚࠸ࡿࠋ୍᪉ࠊn-3 ⣔⬡⫫㓟ࡣ⾑୰ࡢ୰᝟ሗࡀ࡞࠸ࡢ࡛᥎࡛ࡣ࠶ࡿࡀࠊኟᏘࡢࢩ࢝ࡣ࣡ᛶ⬡⫫ࢆῶᑡࡉࡏࡓࡾࠊື⬦◳໬ࢆᢚไࡋࡓࡾࡍࢼࠊᷦ࡟ࡼࡾᤕ⋓㸦⏕ࡅᤕࡾ㸧ࡉࢀࡿࡇ࡜࠿ࡽࠊࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋࡑࡢࡓࡵࠊᡂே⑓ண㜵ࡢ⾑ᢤࡁࡀẚ㍑ⓗᐜ࡛᫆࠶ࡿࡀࠊ෤Ꮨࡣ㖠࡟ࡼࡿᤕ⬡㉁ᰤ㣴ᣦ㔪࡛ࡣ n-6/n-3 ẚࡣ㸯㹼㸲ࡀᮃࡲࡋ࠸⋓㸦ᤕẅ㸧ࡀከࡃ࡞ࡿࡓࡵࠊ⾑ᢤࡁࡀ୙༑ศ࡞ಶ࡜ࡉࢀ࡚࠸ࡿ㸵㸧ࠋ∵⫗ࡢ್ࡀ 23㹼71ࠊ㇜⫗ࡢ್ࡀయࡀከࡃࠊ⤖ᯝ࡜ࡋ࡚㕲ྵ᭷㔞ࡀ㧗࠸⫗ࡀከࡃ࡞ࢩ࢝⫗ࡢ್ࡣኟᏘヨᩱࡀ 4.2ࠊ18㹼46 ࡟ᑐࡋ࡚㸵㸧ࠊࡗ࡚࠸ࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮࢃࢀࡿࠋ௒ᚋࠊᤕ⋓᪉

෤Ꮨࡀ 7.1 ࡜∵⫗࣭㇜⫗࡜ẚ㍑ࡋ࡚኱ᖜ࡟ప࠸ഴ

ἲࡢ᝟ሗ࡟ᇶ࡙࠸ࡓᡂศศᯒࢆ⾜࠸ࠊ᳨ドࡋࡓ࠸ྥࡀぢࡽࢀࡓࠋ
ࡇࢀࡽࡢ⤖ᯝࡼࡾࠊࢩ࢝⫗ࡣ∵⫗ࡸ㇜⫗࡜ẚ㍑

࡜⪃࠼࡚࠸ࡿࠋ
ኟᏘ࠾ࡼࡧ෤Ꮨ࡟࣡ࢼ࡛ᤕ⋓ࡉࢀࡓ᥎ᐃᖺ㱋 3ࡋ࡚ప⬡⫫࡛࠶ࡾࠊ⬡⫫㓟⤌ᡂ࡟࠾࠸࡚ࡶ೺ᗣⓗṓࡢ㞤ࠊྛ 1 㢌ࡢ⫗࡟ࡘ࠸࡚ࠊ㒊఩ูࡢ୍⯡ᰤ㣴࡟ዲࡲࡋ࠸༳㇟ࢆ୚࠼ࡿ㣗ᮦ࡛࠶ࡿ࡜ᛮࢃࢀࡓࠋ

ᡂศ࠾ࡼࡧ㕲ྵ᭷㔞ࢆㄪᰝࡋࡓ⤖ᯝࢆ⾲ 2 ࡟♧ࡋࡓࠋ㒊఩ู࡟ࡼࡿ୍⯡ᡂศ࡟኱ࡁ࡞ᕪࡣࡳࡽࢀ࡞⾲㸱 ࢩ࣮࢝ࣟࢫ⫗⬡⫫㓟ࡢ 36 ẚ࠾ࡼࡧ QQ ẚ࠸ࡀࠊࣔࣔ⫗࡟ࡘ࠸࡚ࡣᖺ㛫ࢆ㏻ࡋ࡚⬡㉁ྵ᭷㔞ࡀప࠸ഴྥࡀࡳࡽࢀࡓࠋࢩ࢝⫗ࡢ⬡⫫㓟⤌ᡂࢩ࢝⫗ࡢ⬡⫫㓟ࡢᵓᡂẚ࡟ࡘ࠸࡚ࠊ⤖ᯝࢆ⾲㸱࡟♧ࡋࡓࠋ㣬࿴⬡⫫㓟㸦S㸧࡟ᑐࡍࡿከ౯୙㣬࿴࢔ࣥࢭࣜࣥࠊ࢝ࣝࣀࢩࣥࡢᐃ㔞

⬡⫫㓟㸦P㸧㸦࢚࢖ࢥࢧ࣌ࣥࢱ࢚ࣥ㓟㸦EPA㸧ࠊࢻࢥࢧ࣊࢟ࢧ࢚ࣥ㓟㸦DHA㸧࡞࡝㸧ࡢẚ㸦P/S ẚ㸧ࡀࠊすᮧࡽ㸷㸧࡟ࡼࡿ࡜ࠊ࢔ࣥࢭࣜࣥࠊ࢝ࣝࣀࢩࣥࡣ

∵⫗ࡀ 0.04㹼0.07ࠊ㇜⫗ࡀ 0.22㹼0.27㸵㸧࡛࠶ࡿࡢᢠ㓟໬స⏝ࠊ⦆⾪స⏝ࠊ⾑⢾್ࡸ⾑ᅽࡢᢚไຠᯝ࡟ᑐࡋ࡚ࢩ࢝⫗ࡣኟᏘヨᩱࡀ 0.77ࠊ෤Ꮨヨᩱࡀࢆ᭷ࡍࡿ࡜ゝࢃࢀ࡚࠸ࡿࠋࢩ࢝⫗ࡢ࢔ࣥࢭࣜࣥࠊ

0.67 ࡜ẚ㍑ⓗ㧗࠿ࡗࡓࠋ࢝ࣝࣀࢩࣥྵ᭷㔞ࢆศᯒࡋࡓ⤖ᯝࢆ⾲㸲࡟♧ࡋࡋ࠿ࡋ࡞ࡀࡽࠊ୙㣬࿴⬡⫫㓟ࡣ㓟໬ࡋࡸࡍࡃࠊ⾲㸲 ࢩ࢝⫗ࡢ࢔ࣥࢭࣜࣥࠊ࢝ࣝࣀࢩࣥྵ᭷㔞⬡㉁㓟໬ࡀ୙ᛌ⮯ࡢཎᅉ࡜࠸࠺ሗ࿌㸶㸧ࡶ࠶ࡿࡓࡵ

ヨᩱࢩ࢝⫗ࡢရ㉁Ᏻᐃ໬ࡢࡓࡵ࡟ࡣ㓟໬㜵Ṇᑐ⟇ࡀኟᏘ䠄㼚㻩㻡䠅
෤Ꮨ䠄㼚㻩㻟䠅
㻌䠕䠅∵䝰䝰⫗㻌䠕䠅㇜䝻䞊䝇ᚲせ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
ࡲࡓࠊn-6/n-3 ẚ㸦n-6 ⣔⬡⫫㓟ᑐ n-3 ⣔⬡⫫㓟

4䜰䞁䝉䝸䞁䠄㼙㼓㻛㻝㻜㻜㼓䠅㻟㻢㻡㻠㻡㻡㻟㻞㻥䜹䝹䝜䝅䞁 䜰䞁䝉䝸䞁㻗䜹䝹䝜䝅䞁䠄㼙㼓㻛㻝㻜㻜㼓䠅䠄㼙㼓㻛㻝㻜㻜㼓䠅㻡㻝㻤㻤㻤㻟㻟㻣㻠㻤㻞㻥㻞㻢㻞㻞㻢㻡㻤㻥㻥㻥㻞㻤?{Sv{)ÊļȄ*ŵrrƺǨy}Qƺ

ȬȩP?SWw*bU}ő)ǆŚ$%řǰ#ã69ǻªƁƺ)ȁįǆ)ƓĢ)¿Ò$*'

%¬{ÊļȄ*ŵƺ57ã0Fw`O%¬Äƽď388%

9(#3ĉƄŶǦĔ¬ƺ6ō«9%*)¨ǄƑȀȨǂįȩƈł)Ĕ¬3ō«98Äƽď   + > 5 3 @  % # ) 1 3 > + > 5 3

Ġž#6ǘ0$ǵǸ(ǌ@!R}

8ċǖ

8L-Fw^W{%?SWwFw^W{)¬Ń<ǌ%ƮŅ<ǏȰ(ƞǒ69%6ƺ)Ïǭ)2(*Ġž#6ǘ0$(ȊĹȍ<8%*Ǿ

7

L-Fw^W{*ƾǭ)Ǧ(ċȜ)Ĕ¬$8.$?SWwFw^W{*ǋŦǁȎȋ<ǷǼǁœƽÉľą98%ÛÌ9#8ȬȫȩƮŅ%'OFƺ)Ïǭ)~Ò%';

30OFƺ) L-Fw^W{*ŵƺ4Ǩƺ573ã

8%Ď;98ļïȦŽ)ǓµȅƯ)2)ƝǣŎ(ȊĹȍ<ǖ#L-Fw^W{?SWwFw^W{%3ÇŁ6)ÛÌȭȩ5744ãŹŻƷ)ǚǊĦƑĔ¬ūíƮŅ63#8%8Äƽď7ȤȐƝǣ)Ėț)ǗƓċǖ$*'%Ď;9%ȬȬȩ)ƮŅ57ȦÁƖƅOFƺ* L-Fw^W{ĩÁŬ%#¯Ɔ$8Äƽďļ8%ƶ69ƾǭÊȄ)ô'%#ťǫƷ(%

#iwO}'ƺ%#ŷĊ"$8%ƶ

698

7.
;+4< =



<=



<B=
86<!#=<A=     *0<B=
951*0>>=@-3)< =26<' (=  WfZdJnwu_ȎƷ-)ƸÁ7)ƮŅ¯ƆǗǴ09#8ǿ)¯Ɔ<É82(*)Ïǭ

<8¿Ò<Ęĥ8%Ȃǖ$
%¬ĠžĹ)Q[xQ(58#ƺ)Ïǭ8%ƶ69)$z]$Ġž9%Ȉ$Ġž9)FUƺ) n!qbI]

³Õśď% pH <ūí

ĠžĆǸ4(¨Ǆ<Ī«ȨǸªƁz]$Ġž9(!

ƺȩ%¨ǄĪ«0$ȯĹȍƭǼȨǻªƁƺȩ)y}Qƺ<¥Ė)ǽ

O yHgnzHgn!qbVI!{  ,?94-<:,/: !&%$("$&!&%$(< =< = ?=s   . + ? B 0 n D !  + > 5 3 @  % # ) 1 3 > + >53@!M[}    (<ǥŇ%)ǿ®)ƺ)Ïǭ<ǥŇ)ƮŅz]$Ġž9%Ȉ$Ġž9:ǻªƁƺ(*ȁįǆē69GQJ<řǰ8%z]$Ġž9)ĳyn[KufǭȄ¬Ńǜȩ(57ĦƑďĔ¬<¬ŃƮŅĉƄŶ)Ǧ¹ÆŶ)~!$#*±ǀz]

8P?SWwȨ2,3-gU{PE{ȩō«9ȨÓ5řǰƒƺ)Ǐș(jU!

7śďȨ³ÕśďȩȨǏȱȩ³Õ%¬ ࠾ࢃࡾ࡟ಖỈᛶࡣᩘ್ࡀ㧗࠸᪉ࡀಖỈᛶࡢ㧗࠸⫗࡛࠶ࡾࠊ㸦㸯㸧㫽ྲྀ┴ⱝᱜ⏫ෆ࡛ᤕ⋓ࡉࢀࡓࢩ࢝ࡢ࣮ࣟࢫࢪ࣮ࣗࢩ࣮ࡉࡀ࠶ࡿࡇ࡜ࢆព࿡ࡍࡿࡇ࡜࠿ࡽࠊ࣡ࢼ࡛ࡢᤕ⋓ࡣ㖠࡟ẚ࡭࡚⫗㉁ࡀຎࡿࡇ࡜ࡀุ᫂

⫗࡟ࡘ࠸࡚ࠊ୍⯡ᰤ㣴ᡂศࢆㄪᰝࡋࡓ⤖ᯝࠊࡋࡓࠋࡲࡓࠊ࣡ࢼ࡛ᤕ⋓ࡉࢀࡓಶయ࡟ࡘ࠸࡚ࡣࠊࢩ࢝⫗ࡣ∵ࡸ㇜࡜ẚ㍑ࡋ࡚⬡㉁ྵ᭷㔞ࡀ࣡ࢼ࡟࠿࠿ࡗࡓ⬮ഃࡢಖỈᛶࡢ᪉ࡀపࡃࠊ࣡ࢼࡢᴟࡵ࡚ᑡ࡞࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋ⬡㉁ྵ᭷㔞ᤕ⋓ࡣ⫗㉁࡬ࡢᙳ㡪ࡀ኱ࡁ࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋ

ࡀᑡ࡞࠸ࡢ࡛ᾘ㈝⪅࡟ࡣ࣊ࣝࢩ࣮࡞⫗࡛࠶ࡿ࡜ࡢ༳㇟ࢆ୚࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮࢃࢀࡓࠋ⾲㸴 ᤕ⋓᪉ἲูࢩ࢝࢝ࢱ⫗ࡢຍᅽಖỈᛶຍᅽಖỈᛶ䠄㻑䠅ᤕ⋓᪉ἲ㖠㸦㸰㸧㒊఩ู࡛ࡣࠊᖺ㛫ࢆ㏻ࡋ࡚ࣔࣔ⫗ࡢ⬡㉁ྵ
᭷㔞ࡀᑡ࡞࠿ࡗࡓࠋ㻤㻜㻚㻤䝽䝘䠄䠍䠅㻣㻤㻚㻢䝽䝘䠄䠎䠅㻢㻥㻚㻠㸦㸱㸧㕲ྵ᭷㔞ࡣࠊ௚ࡢ␆⫗࡜ẚ㍑ࡋ࡚ከ࠸ഴྥ
࡟࠶ࡾࠊ≉࡟෤ᏘヨᩱࡣኟᏘヨᩱࡸᩥ⊩್࡜ẚ㍑ࡋ࡚ከ࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋヨᩱࡢᤕ⋓᪉ἲࡢ᝟ሗࡀ࡞࠸ࡢ࡛᥎䠄䠍䠅㻌䝽䝘䛻䛛䛛䛳䛯⬮䛸཯ᑐഃ䛾㒊఩䠄䠎䠅㻌䝽䝘䛻䛛䛛䛳䛯⬮䛸䛴䛺䛜䛳䛶䛔䜛㒊఩࡛ࡣ࠶ࡿࡀࠊኟᏘࡢࢩ࢝ࡢᤕ⋓ࡣ࣡ࢼࠊᷦ࡟ࡼࡿࡓࡵࠊ⾑ᢤࡁࢆ༑ศ࡟⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࡀࠊ෤Ꮨ

ḟ࡟ pH ࡢᐃ⤖ᯝࢆ⾲㸵࡟♧ࡋࡓࠋ㖠࡛ᤕ⋓ࡣ㖠࡟ࡼࡿᤕ⋓ࡀከࡃ࡞ࡿࡓࡵࠊ⾑ᢤࡁࡀࡉࢀࡓಶయࡀ 6.0 ࡛࠶ࡗࡓࡢ࡟ᑐࡋ࡚ࠊ࣡ࢼ࡛ᤕ

୙༑ศ࡟࡞ࡿಶయࡀቑ࠼࡚࠸ࡿྍ⬟ᛶࡶ⋓ࡉࢀࡓಶయࡢ pH ࡣࠊ6.6 ࡜㧗࠸ᩘ್࡛࠶ࡗࡓࠋ

࠶ࡿࠋ

㏻ᖖࡢ␆⫗࡛ࡣ pH ࡀ 6 ࢆ㉸࠼࡚࠸ࡿ⫗ࡣ␗ᖖ⫗㸦㸲㸧ࢩ࢝⫗ࡢ⬡⫫㓟⤌ᡂ࡛ࡣࠊP/S ẚࡀࠊ∵⫗

࡜ࡋ࡚ὶ㏻ࡋ࡞࠸ࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࡇ࡜㸯㸰㸧࠿ࡸ㇜⫗࡜ẚ㍑ࡋ࡚ẚ㍑ⓗ㧗ࡃࠊn-6/n-3 ẚ࡛ࡽࠊ⊁⊟࡛ᤕ⋓ࡋࡓࢩ࢝⫗ࡣ pH ࡢ㠃࠿ࡽࠊࡸࡸ

ࡣࠊ∵⫗ࡸ㇜⫗࡜ẚ㍑ࡋ࡚኱ᖜ࡟ప࠸ࡇ࡜

ㄢ㢟ࡀ࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ⫗ࡢ pH ࡣࠊࡀศ࠿ࡾࠊ೺ᗣⓗ࡞㣗ᮦ࡜ࡋ࡚ࡢ༳㇟ࢆ୚⫗୰ࡢࢢࣜࢥ࣮ࢤࣥࡀ᎘Ẽⓗ࡟ศゎࡉࢀ࡚ங㓟࠼ࡿࡇ࡜ࡀฟ᮶ࡿࡢ࡛ࡣ࡞࠸࠿࡜ᛮࢃࢀ࡟ศゎࡉࢀࡿࡇ࡜࡟ࡼࡗ࡚పୗࡍࡿࡀࠊᒕẅ๓ࡢࡓࠋࢫࢺࣞࢫ㸦⑂ປ㸧࡟ࡼࡾࢢࣜࢥ࣮ࢤࣥࡀᾘ㈝ࡉࢀ

㸦㸳㸧୍᪉࡛ࠊ୙㣬࿴⬡⫫㓟ࡀከ࠸ࢩ࢝⫗ࡣ㓟໬࡚ࡋࡲ࠸ࠊᒕẅᚋ࡟ pH ࢆୗࡆࡿங㓟ࡀᑡ࡞ࡃ࡞ࡉࢀࡸࡍ࠸࡜࠸࠺ഃ㠃ࢆ᭷ࡋ࡚࠸ࡿࡓࡵࠊࡗ࡚ࡋࡲࡗ࡚࠸ࡿࡇ࡜ࡀཎᅉ࡛ࡣ࡞࠸࠿࡜ᛮࢃ⬡㉁㓟໬㜵Ṇᑐ⟇ࡀᚲせ࡟࡞ࡿࡇ࡜ࡀ♧ࢀࡿࠋࡇࡢࡇ࡜࠿ࡽࠊ࣡ࢼࡼࡾࡶࢫࢺࣞࢫࡢᑡ࡞၀ࡉࢀࡓࠋ࠸㖠࡛ࡢᤕ⋓ࡢ࡯࠺ࡀࠊ⫗ࡢ pH ࡀపࡃࠊዲࡲࡋ㸦㸴㸧ᢠ㓟໬స⏝ࠊ⦆⾪స⏝ࠊ⾑⢾್ࡸ⾑ᅽࡢᢚ࠸ࡇ࡜ࡀศ࠿ࡗࡓࡀࠊኟᏘࡣ⊟㖠ࡀ౑⏝࡛ࡁ࡞࠸ไຠᯝࢆ᭷ࡍࡿ࡜ゝࢃࢀ࡚࠸ࡿ࢔ࣥࢭࣜࡓࡵࠊ⫗㉁ࡢࡓࡵ࡟ࡣࠊᷦࡸ࣡ࢼ➼࡛ࡢࢫࢺࣞࢫࣥࠊ࢝ࣝࣀࢩࣥࢆㄪᰝࡋࡓ⤖ᯝࠊ࢔ࣥࢭࣜࡢపῶ᪉ἲࢆ㛤Ⓨࡍࡿᚲせࡀ࠶ࡿ࡜ᛮࢃࢀࡓࠋࣥྵ᭷㔞ࡣ∵ࣔࣔ⫗ࠊ㇜࣮ࣟࢫ⫗࡜ẚ㍑ࡋ
࡚ከࡃࠊ࢝ࣝࣀࢩࣥྵ᭷㔞ࡣ∵⫗ࡼࡾከ࠸⾲㸵 ᤕ⋓᪉ἲูࢩ࢝࢝ࢱ⫗ࡢ S+ᤕ⋓᪉ἲ㼜㻴㖠㻢㻚㻜䝽䝘ࡇ࡜ࡀศ࠿ࡗࡓࠋ
㸦㸵㸧ࢩ࣮࢝ࣟࢫ⫗ࡢ L-࢝ࣝࢽࢳࣥ࡜࢔ࢭࢳࣝ࢝

㻢㻚㻢㻌䠍䠎䠅ᩥ⊩್㻡㻚㻣㼼㻜㻚㻞

ࣝࢽࢳࣥࡢ


ᐃࡋࡓ࡜ࡇࢁࠊL-࢝ࣝࢽࢳࣥࡣ∵⫗ࡸ㇜⫗࡜ẚ㍑ࡋ࡚ከ࠸ࡇ࡜ࡀࢃ࠿

6ࡗࡓࠋ

p.137(2004).

㸦㸶㸧ప฼⏝ࡀぢ㎸ࡲࢀ࡚࠸ࡿಶయࡸ㒊఩ࡢ⫗㉁㸯㸰㸧▼⏣ࡽ; ᪥ᮏ␆⏘Ꮫ఍ሗ, 67(6), p.567(1996).

ㄪᰝࢆ⾜ࡗࡓ࡜ࡇࢁࠊᤕ⋓ᚋෆ⮚᦬ฟࡲ࡛㸲᫬㛫⤒㐣ࡋࡓಶయࡢ࣮ࣟࢫ⫗ࡣࠊࢪ࢔ࢭࢳࣝࡀከࡃ᳨ฟࡉࢀࡓࠋࡲࡓࠊ࣡ࢼ࡛ᤕ⋓ࡉࢀࡓಶయࡣࠊ⫗ࡢຍᅽಖỈᛶࡀపୗࡋࠊpH ࡀ㧗࠸ഴྥࡀぢࡽࢀࡓࠋࡉࡽ࡟ࠊẚ㍑ⓗᤕ⋓᫬ࡢࢫࢺࣞࢫࡀᑡ࡞࠸࡜ᛮࢃࢀࡿ㖠࡛ᤕ⋓ࡉࢀࡓಶయࡢ᪉ࡀ࣡ࢼ࡛ᤕ⋓ࡉࢀࡓಶయ࡟ẚ࡭࡚ࠊ⫗ࡢຍᅽಖỈᛶࡀ㧗ࡃࠊpH ࡣࡸࡸప࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋ

ㅰ ㎡ᮏ◊✲ࡣࠊ㫽ྲྀ┴ཷク஦ᴗࠕᖹᡂ㸰㸴ᖺᗘ࡜ࡗ࡜ࡾࢪࣅ࢚฼⏝ಁ㐍⥲ྜᑐ⟇஦ᴗࠖ࡟ࡼࡾ⾜ࢃࢀࡓࡶࡢ࡛࠶ࡿࡇ࡜ࢆࡇࡇ࡟᫂グࡋࡲࡍࠋᩥ ⊩㸯㸧 ᖹᡂ㸰㸲ᖺᗘ㫽⋇⤫ィ᝟ሗ㸦⎔ቃ┬࣮࣒࣮࣍࣌ࢪ㸧.
㸰 㸧 ྜྷ ᮧ ࡽ ; ᪥ ᮏ 㣗 ရ ⛉ Ꮫ ᕤ Ꮫ ఍ ㄅ , 59(12),p.637-642(2012).
㸱㸧 ᐙ␆ᨵⰋࢭࣥࢱ࣮ᢏ⾡࣐ࢽࣗ࢔ࣝ 21 㣗⫗ࡢ⌮໬Ꮫศᯒཬࡧᐁ⬟ホ౯࣐ࢽࣗ࢔ࣝ, ⊂❧⾜ᨻἲேᐙ␆ᨵⰋࢭࣥࢱ࣮, p.15-16(2010).
㸲㸧஬ゞቑ⿵

᪥ᮏ㣗ရᶆ‽ᡂศ⾲,p.178-192(2005).
㸳 㸧 ྜྷ ᮧ ࡽ ; ᪥ ᮏ ᰤ 㣴 ࣭ 㣗 ⣊ Ꮫ ఍ ㄅ , 66(2),p.95-99(2013).
㸴㸧஬ゞቑ⿵ ᪥ᮏ㣗ရᶆ‽ᡂศ⾲, p.188(2005).
㸵㸧➟஭ࡽ; ࢽ࣮ࣗࣇ࣮ࢻ࢖ࣥࢲࢫࢺ࣮ࣜ, 42(7),p.1-8(2000).
㸶 㸧 Ώ ㎶ ࡽ ; ᪥ ᮏ ␆ ⏘ Ꮫ ఍ ሗ , 69(5),p.489-492(1997).
㸷㸧すᮧ; ᪥ᮏㄪ⌮Ꮫ఍ㄅ, 41(4), p.221(2008).
㸯 㸮 㸧 Barhwal, K. et al.; Neuroscience, 161,p.501-514 (2009).
㸯㸯㸧Demarquoy, J. et al.; Food Chemistry, 86,7