DATA SHEETCOL01369

Thermo Scientific
DHX Heat Exchanger
Sterile, Efficient and Modular
The Thermo Scientific™ DHX™ isa modular heat exchanger that uses
single-use a BioProcess Container(BPC) as the sterile fluid path. TheBPCs fit tightly between five stainlesssteel plates, efficiently transferring
heat in a counter-current flow path.
The system provides efficient, sterile
heat transfer that easily integrates
into any new or existing process.

DHX BPCs
The BPCs in the heat transfer
process ensure a closed and sterile
fluid path, eliminate the risk of crosscontamination and greatly reduceturnaround time between batches.
Each BPC fits tightly between thestainless steel plates and theprocess fluid, in the BPCs, flows
counter-currently to the heating/cooling
fluid in the plates. This method ofheat transfer is superior to traditional
jacketed systems and the modular
footprint allows for use in multiple
process locations.

Benefits

Applications• Completely isolated flow paths forprocess fluid and heat transfer fluid• cGMP commercial and clinicalbio-therapeutics, vaccines andother biologic processes.

• Counter-current, serpentine
flow patterns• Dimpled jacketing on the plates
to ensure turbulent flow
• Modular design and small footprint
allows for changing process needs• Reduced infrastructure requirements• Reduced processing time
• Improved product consistency• Upstream applications include:
media hold, fermentation, cell
separation / protein harvest,
harvest cooling and harvest hold.
• Downstream applications include:
harvest hold, buffers, protein
purification, and bulk drug substanceDHX BPCs

DHX bioprocess equipment - plate system

General Specifications

General Specifications

Material of construction

Thermo Scientific™
ASI™ 26/77 filmInterconnecting tubing

C-FlexConnections

GE ReadyMate™ DAC 500
as standard – Custom
tubing and connections
upon request

Flow rate capacity

Up to 15 L/min

Pressure/temperature rating(Installed in DHX plates)

20 psig at 122°F (50°C)

Heat transfer efficiencies for typical applications
Cooling from 37°C – single passMaterial of construction

316L Stainless Steel

Effective heat transfer area

Up to 27 sq. ft.

Overall dimensions(W x D x H)

51 x 74 x 69 cm(20 x 29 x 27 in.)

Number of plates/BPCs

5 plates/up to 4 BPCs

Dry weight

150 kg (331 lbs.)

Full weight (includes 4 BPCs)

190 kg (419 lbs.)

Pressure/temperature rating

FV/140 psig @ 150°F

Pressure vessel code

ASME U-1Connections

1/2 in. compression• Process fluid: water at 37°C
• Heat transfer fluid: 30% Propylene Glycol at 2°C

Efficient Heat Transfer• Heat transfer flow rate: 15 L/min

Counter Current Flow Between the Heating / Cooling
Fluid and the Process Fluid: The purple shading depicts
the serpentine flow path of the process fluid in the BPCs.
The dimpled plate behind the single-use BPC depicts
where the heating / cooling fluid flows counter-currently
to the process fluid in a completely isolated flow path.

• Number of BPCs: 4• DHX cooling efficiencies measured by temp. vs. time:
DHX COOLING EFFICIENCES
403530Temp

25TEMP(oC) (oC)2011 LPM
L/min
33 LPM
L/min
55 LPM
L/min
1010LPM
L/min

15Process fluid

1515LPM
L/min

10500510

15

2025

30

TIME (min)Time (min)Heating from ambient temperature – single pass
• Process fluid: Water at 20°C
• Heat transfer fluid: 30% Propylene Glycol at 42°C
• Heat transfer flow rate: 15 L/minHeat transfer fluid• Number of BPCs: 4• DHX heating efficiencies
by temp. vs. time:
DHX HEATINGmeasured
EFFICIENCIES
4540Temp

11LPM
L/min
35

33LPM
L/min

TEMPo(oC)

55LPM
L/min( C)

10LPM
L/min
1030

15LPM
L/min
1525

200

51015

Time(min)
TIME(min)202530Ordering information
Product
DHX Heat Exchanger

Cat. No.
316L stainless steel bioprocessing equipment

DHX1001

One BPCASI 26/77 film, DAC connections on outlet ports

DX00006-I

Two BPC assembly

ASI 26/77 film, DAC connections on outlet ports

DX00007-I

Three BPC assembly

ASI 26/77 film, DAC connections on outlet ports

DX00008-I

Four BPC assembly

ASI 26/77 film, DAC connections on outlet ports

DX00009-I

One BPCASI 26/77 film, DAC connections and drain tubing

DX00010-I

Two BPC assembly

ASI 26/77 film, DAC connections and drain tubing

DX00011-I

Three BPC assembly

ASI 26/77 film, DAC connections and drain tubing

DX00012-I

Four BPC assembly

ASI 26/77 film, DAC connections and drain tubing

DX00013-I

DHX Single-Use BPCs

Find out more at thermofisher.com/sut© 2016 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unlessotherwise specified. ReadyMate is a trademark of GE Healthcare Bio-Sciences AB. COL01369 0716