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Mitochondrial transplantation therapyaLl
C membrane oxygenationcells,
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causingcan
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pump
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efficiently.
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pack on a carIschemia,
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says about theeffects of mitochondrial
To perform mitochondrial transplantation, Emani harvests a small, pencil­eraser­sized piece of tissue fromcongenitalheart
defects
coronary
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restricted blood flow, cantransplantation
be caused
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in rabbit,
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ore blood flow
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sl aLl C artery disease and cardiac arrest. Now, McCully is working withMitochondrialtransplantation saved Avery’s life. Read her story.
heart surgeon Sitaram Emani, MD, to bring mitochondrial transplantation
mitochondria and their DNA remain damaged. A, Biopsy of nonischemic
Today,who
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Avery
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For theskeletal
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LUCA
ScienceInc.
Mitochondrial transplantation saved Avery’s life

FIGURE
Biopsynonischemicskeletalskeletalmuscle.B,B,Injection
Injectionofofautologous
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IGURE
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Againsttherapeutics
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LUCA Science Inc.
Extracellular mitochondria
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predicted
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thepatient’s
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sickmuscle
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betweencells
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ence
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LUCA Science Inc.
Scholkmann F. Theor Biol Med Model. 2016 Jun 6;13(1):16.
demonstrateefficacy
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imageshttps://vector.childrenshospital.org/2018/07/hearts-get-a-boost-from-mitochondrial-transplantation/
2/6“
or decades, cardiac researcher James McCully, PhDsuccessfully
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he mitochondria and their DNA remain damaged. 4
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Mitochondrial transplantation saved Avery’s life. Read her story.

“We know this is their only chance to come off ECMO,” says Emani. “Since we use the patient’s own

haveimproved
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cribed
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ents
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alternative
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including transco
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CONCLUSIONS
alternative
deliveryoveryofventricularfunction
did
not
seem
likely.
Futureveryofventricularfunction
did
not
seem
likely.
Futurechemia-reperfusion
injury.Patients
Patientsdid
didnotnothavehaveadverse
adverseemia-reperfusion injury.
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cases
demonstratethefirstclinicalclinicalapplicappl
delivery,arecurrently
undertheinvestigation.
These
cases
demonstrate
first
are
currently
underinvestigation.
dies
investigating
therelated
optimaltimingofoftherapy
therapy
are delivery,esinvestigatingtheoptimalare
ort-term
complications
relatedmitochondrial
injection
rt-term
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tototiming
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injectionnovel
techniquemitochondrial
autotransplan
Therewasnonodetectabledetectabledifference
betweenprein
pre
novel
techniqueofofmitochondrial
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difference
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ventricularfunctionmightssary.
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possiblethat
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rrhythmia,
intramyocardialhematoma,orscarring),
andhythmia, intramyocardial hematoma, or scarring), andmay
beevidenced
usefulfor
patients
withischemia-reperfu
andpostinjection
markersofinfla
rejection
at
the
sites
injection,and inflam
white
may
be
usefulfor
patients
withischemia-reperfusi
andpostinjection
markersofof
systemic
ic
l
C Of
and
randomized
clinicaltrialisistherefore
therefore
necessary
tolatedepicardial
injections.
Ofthe
the5 5subjects,
subjects,
response
syndrome(asevidenced
stablerespiratorya arandomized
clinicaltrial
necessary
tosystemic
ted totoepicardial
injections.
4 4 inand
response
syndrome(asbyby
stablerespiratorymodels.
The patients
thisseries,however,
wereselected

cribedTable1.1.None
Noneofofthe
thepatientspatientshad
hadarrhythmias
arrhythmiasoror
ibed ininTable
eding
relatedtotoepicardial
epicardialinjections.
injections.OfOfthe
the5 5subjects,
subjects,4 4
ing related
monstrated
improvementininventricular
ventricularfunction
functionand
andwerewere
onstrated improvement
cessfullyseparated
separatedfrom
fromECMO
ECMOsupport.
support.
essfully

mitochondria, the risks are relatively low.”With consent from a patient’s family, Emani and McCully spring into action.

To perform mitochondrial transplantation, Emani harvests a small, pencil­eraser­sized piece of tissue froman area of the patient’s skeletal muscle that has been unaffected by ischemia. Then, from the harvested
tissue — which can contain upwards of 100 million mitochondria — McCully works fast to purify the
mitochondria and prepare the transplant.

“Time is of the essence,” McCully explains. “The healthy mitochondria must be extracted and transplanted
quickly before they, too, become damaged by lack of blood flow.”

CONG
CONG

https://vector.childrenshospital.org/2018/07/hearts-get-a-boost-from-mitochondrial-transplantation/

Mitochondrial transplantation saved Avery’s life. Read her story.

2/6

CONG
CONG

https://vector.childrenshospital.org/2018/07/hearts-get-a-boost-from-mitochondrial-transplantation/