CURRICULUM VITAEMICHIO SATO
Assistant Professor
School of Pharmaceutical Sciences
University of Shizuoka, Shizuoka
422-8526, JAPAN
Tel: +81-54-264-5912 (office)Fax: +81-54-264-5666; E-mail: michio@u-shizuoka-ken.ac.jp
EDUCATION:
Ph.D., M.S., Bioorganic Chemistry
Hokkaido University, Sapporo, Japan
Thesis Advisor: Professor Nabeta Kensuke

March 2011

B.Sc., Bioorganic Chemistry
Hokkaido University, Sapporo, Japan
Thesis Advisor: Professor Nabeta Kensuke

March 2006

PROFESSIONAL EXPERIENCE:
2017/4-

School of Pharmacy, University of Shizuoka
Assistant Professor

2015-2017

UCLA, Chemical and Biomolecular Engineering
Postdoctoral Fellow
Principal Investigator: Professor Yi Tang

2014-2015

UC Berkeley, Chemical and Biomolecular Engineering
Visiting scholar
Principal Investigator: Assistant professor Wenjun Zhang

2011-2014

School of Pharmacy, University of Shizuoka
Postdoctoral Fellow
Principal Investigator: Professor Kenji Watanabe
Research: Biosynthetic study on azaphilones from fungi

2006-2011

Department of Applied Bioscience, Hokkaido University
Principal Investigator: Professor Kensuke Nabeta
Research: Biological activity of ppGpp in chloroplasts

HONORS AND AWARDS:
Postdoctoral fellowship (Fellowship of Astellas Foundation, JAPAN) 2015-2016
Postdoctoral fellowship (The Uehara Memorial Foundation, JAPAN) 2014-2015
Training Grant. Japan Society for the Promotion of Science2009-2011

PROFESSIONAL SOCIETIES:
American chemical society
Japan Society for Bioscience, Biotechnology, and Agrochemistry
The Pharmaceutical Society of Japan
PUBLICATIONS:
1. Ohashi M., Liu F., Hai Y., Chen M., Tang M.C., Yang Z., Sato M., Watanabe K., Houk K.N., Tang
Y. “SAM-Dependent Enzyme-Catalysed Pericyclic Reactions in Natural Product Biosynthesis.”Nature, 2017, 549, 502-506.
2.

Harris N.C., Sato M., Herman N.A., Twigg F., Cai W., Liu J., Zhu X., Downey J., Khalaf R.,
Martin J., Koshino H., Zhang W. “Biosynthesis of Isonitrile Lipopeptides by Conserved
Non-ribosomal Peptide Synthetase Gene Clusters in Actinobacteria”
Proc. Natl. Acad. Sci. U. S. A., 2017, 114, 7025-7030.

3.

Kishimoto S, Tsunematsu Y, Sato M, Watanabe K. “Elucidation of biosynthetic pathways ofnatural products.”
Chem. Rec., 2017, 17, 1-15.

4.

Sato M, Dander J.E, Sato C, Hung Y.S, Gao S.S, Tang M.C, Hang L, Winter J.M, Garg N.K,Watanabe K, Tang Y. “Collaborative Biosynthesis of Maleimide- and Succinimide-Containing
Natural Products by Fungal Polyketide Megasynthases.”
J. Am. Chem. Soc., 2017, 139, 5317-5320.

5.

Kishimoto S, Sato M, Tsunematsu Y, Watanabe K. “Evaluation of Biosynthetic Pathway andEngineered Biosynthesis of Alkaloids.”
Molecules, 2016, 21, E1078.

6.

Sato M, Winter J.M, Kishimoto S, Noguchi H, Tang Y, Watanabe K. “Collaborative Biosynthesisof Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide
Megasynthases.”Org. Lett., 2016, 18, 1446-1449.

7.

Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi Y.H, Goda Y, Xu W, Noguchi H,

Yamamoto T, Hotta K, Houk K.N, Tang Y, Watanabe K. “Involvement of Lipocalin-like CghA in
Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.”
ChemBioChem, 2015, 16, 2294-2298.
8.

Winter J.M, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya M.R, Vederas J.C, Tang Y.
“Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide
Biosynthesis.”J. Am. Chem. Soc., 2015, 137, 9885-9893.

9.

Sato M, Yamada H, Hotta K, Noguchi H, Watanabe K. “ Identification and characterization ofshanorellin biosynthetic pathway.”
MedChemComm, 2015, 6, 425-430.

10. Sato M, Takahashi T, Ochi K, Matsuura H, Nabeta K, Takahashi K. “Overexpression of RelA/SpoT
homologs, PpRSH2a and PpRSH2b, induces the growth suppression of the moss P. patens.”
Biosci. Biotechnol. Biochem., 2015, 79, 36-44.
11. Hotta K, Keegan R.M, Ranganathan S, Fang M, Bibby J, Winn M.D, Sato M, Lian M, Watanabe K,Rigden D.J, Kim C.Y. “Conversion of a disulfide bond into a thioacetal group during echinomycin
biosynthesis.”Angew. Chemie. Int. Ed. Engl., 2014, 86, 242-248.
12. Nakazawa T, Ishiuchi K, Sato M, Tsunematsu Y, Sugimoto S, Gotanda Y, Noguchi H, Hotta K,
Watanabe K. “Targeted disruption of transcriptional regulators in Chaetomium globosum activatesbiosynthetic pathways and reveals transcriptional regulator-like behavior of aureonitol.”
J. Am. Chem. Soc., 2013, 135, 13446-13455.
13. Sato M, Nakazawa T, Tsunematsu Y, Hotta K, Watanabe K. “Echinomycin biosynthesis.”
Curr. Opin. Chem. Biol., 2013, 17, 537-545.
14. Winter J.M, Sato M, Sugimoto S, Chiou G, Garg N.K, Tang Y, Watanabe K. “Identification andcharacterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum
reveal dual functions of an iterative highly-reducing polyketide synthase.”
J. Am. Chem. Soc., 2012, 134, 17900-17903.
15. Ishiuchi K, Nakazawa T, Ookuma T, Sugimoto T, Sato M, Tsunematsu Y, Ishikawa N, Noguchi H,Hotta, K, Moriya, H, Watanabe, K. “Establishing a new methodology for genome mining andbiosynthesis of polyketides and peptides through yeast molecular genetics.”
ChemBioChem, 2012, 13, 846-854.
16. Kitaoka N, Matsubara T, Sato M, Takahashi K, Wakuta S, Kawaide H, Matsui H, Nabeta K,

Matsuura H. “Arabidopsis CYP94B3 encodes jasmonyl-L-isoleucine 12-hydroxylase, a key
enzyme in the oxidative catabolism of jasmonate.”
Plant Cell Physiol., 2011, 52, 1757-1765.
17. Hashimoto T, Takahashi K, Sato M, Bandara P.K.G.S.S, Nabeta K. “Cloning and characterizationof an allene oxide cyclase, PpAOC3, in Physcomitrella patens.”
Plant Growth Regulation, 2011, 65, 239-245.
18. Saruwatari T, Praseuth A.P, Sato M, Torikai K, Noguchi H, Watanabe K. “A comprehensive
overview on genomically directed assembly of aromatic polyketides and macrolide lactones using
fungal megasynthases.”J. Antibiot., 2011, 64, 9-17.
19. Bandara P.K.G.S.S, Takahashi K, Sato M, Matsuura H, Nabeta K. “Cloning and Functional
Analysis of an Allene Oxide Synthase in Physcomitrella patens.”
Biosci. Biotechnol. Biochem., 2009, 73, 2356-2359.
20. Sato M, Takahashi K, Ochiai Y, Hosaka T, Ochi K, Nabeta K. “Bacterial alarmone, guanosine
5’-diphosphate 3’-diphosphate (ppGpp), predominantly binds the β’ subunit of plastid-encoded
plastid RNA polymerase in chloroplasts.”
ChemBioChem, 2009, 10, 1227-1233.