Curriculum Vitae
Eiji Umemoto, Ph.D.
Professor
Laboratory of Microbiology and Immunology,
School of Pharmaceutical Sciences, University of Shizuoka
52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan
Tel: +81-54-264-5716, Fax: +81-54-264-5715
E-mail: eumemoto@u-shizuoka-ken.ac.jp
Education and Appointments
1995-1999
Faculty of Science, Kyoto University
1999-2001
Graduate School of Biostudies, Kyoto University
2001-2005
Osaka University Graduate School of Medicine
Ph.D. in Medical Science
2005-2007
Research Associate, Laboratory of Immunodynamics, Graduate
School of Medicine, Osaka University
2007-2012
Assistant professor, Laboratory of Immunodynamics, Graduate Schoolof Medicine, Osaka University
2012-2020
Associate professor, Laboratory of Immune Regulation, Graduate
School of Medicine, Osaka University
2020-persent
Professor, Laboratory of Microbiology and Immunology, School of
Pharmaceutical Sciences, University of Shizuoka
Research Field of Interest
Mucosal Immunology, Gut microbiota, Metabolites
Selected Publications
1. Simmons S, Sasaki N, Umemoto E, Uchida Y, Fukuhara S, Kitazawa Y, Okudaira M, Inoue A,Tohya K, Aoi K, Aoki J, Mochizuki N, Matsuno K, Takeda K, Miyasaka M, and Ishii M. Highendothelial cell-derived S1P regulates dendritic cell localization and vascular integrity in thelymph node. eLife. 8: e41239. 2019
2. *Morita N, *Umemoto E, Fujita S, Hayashi A, Kikuta J, Kimura I, Haneda T, Imai T, Inoue A,Mimuro H, Maeda Y, Kayama H, Okumura R, Aoki J, Okada N, Kida T, Ishii M, Nabeshima R,Takeda K. (*equal contribution) GPR31-dependent dendrite protrusion of intestinal CX3CR1+

cells by bacterial metabolites. Nature. 566:110-114. 2019
3. Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta
Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi
S, Takeda K. Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T
Cells in the Intestine. Arthritis Rheumatol. 68:2646-2661. 2016
4. Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E,Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii
M, Takeda K, Jalkanen S, *Miyasaka M, *Umemoto E. (*equal correspondence). Fibroblastic
reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility. eLife. 5:e10561. 2016
5. Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K. Dual functions ofRap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis. Nat Commun.
6:8982. 2015
6. Masahata K, Umemoto E, Kayama H, Kotani M, Nakamura S, Kurakawa T, Kikuta J, Gotoh K,Motooka D, Sato S, Higuchi T, Baba Y, Kurosaki T, Kinoshita M, Shimada Y, Kimura T, Okumura
R, Takeda A, Tajima M, Yoshie O, Fukuzawa M, Kiyono H, Fagarasan S, Iida T, Ishii M, Takeda
K. Generation of colonic IgA-secreting cells in the caecal patch. Nat Commun. 5:3704. 2014
7. *Umemoto E, Takeda A, Jin S, Luo Z, Nakahogi N, Hayasaka H, Lee CM, Tanaka T, MiyasakaM.

(*correspondence)

Dynamicchanges

inendothelialcelladhesion

moleculenepmucin/CD300LG expression under physiological and pathological conditions. PLoS One. 8:e83681. 20138.

#Bai Z, #Cai L, #*Umemoto E, #Takeda A, Tohya K, Komai Y, Veeraveedu PT, Hata E, Sugiura Y,Kubo A, Suematsu M, Hayasaka H, Okudaira S, Aoki J, Tanaka T, Albers HM, Ovaa H, *Miyasaka
M. (#equal contribution, *equal correspondence). Constitutive lymphocyte transmigration acrossthe basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acidaxis. J Immunol. 190:2036-2048. 2013
9. *Umemoto E, *Otani K, Ikeno T, Verjan Garcia N, Hayasaka H, Bai Z, Jang MH, Tanaka T,Nagasawa T, Ueda K, Miyasaka M. (*equal contribution) Constitutive plasmacytoid dendritic cell
migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediatedsignaling. J Immunol. 189:191-199. 2012
10. Verjan Garcia N, Umemoto E, Saito Y, Yamasaki M, Hata E, Matozaki T, Murakami M, Jung YJ,Woo SY, Seoh JY, Jang MH, Aozasa K, Miyasaka M. SIRPα/CD172a regulates eosinophil
homeostasis. J Immunol. 187:2268-2277. 2011
11. Jin S, *Umemoto E, Tanaka T, Shimomura Y, Tohya K, Kunizawa K, Yang BG, Jang MH, Hirata
T, Miyasaka M. (*correspondence). Nepmucin/CLM-9, an Ig domain-containing sialomucin in
vascular endothelial cells, promotes lymphocyte transendothelial migration in vitro. FEBS Lett.

582:3018-3024. 2008
12. Furukawa Y, Umemoto E, Jang MH, Tohya K, Miyasaka M, Hirata T. Identification of novel
isoforms of mouse L-selectin with different carboxyl-terminal tails. J Biol Chem. 283:1211212119. 2008
13. Umemoto E, Tanaka T, Kanda H, Jin S, Tohya K, Otani K, Matsutani T, Matsumoto M, Ebisuno
Y, Jang MH, Fukuda M, Hirata T, Miyasaka M. Nepmucin, a novel HEV sialomucin, mediates Lselectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow. J Exp Med.
203:1603-1614. 2006
14. Takeuchi E, Tanaka T, Umemoto E, Tomita T, Shi K, Takahi K, Suzuki R, Ochi T, Miyasaka M.
VLA-4-dependent and -independent pathways in cell contact-induced proinflammatory cytokine
production by synovial nurse-like cells from rheumatoid arthritis patients. Arthritis Res. 4: R10.
2002
15. Park CG, Takahara K, Umemoto E, Yashima Y, Matsubara K, Matsuda Y, Clausen BE, Inaba K,Steinman RM. Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. IntImmunol. 13:1283-1290. 2001,