PROGRAM
Oral Presentation
1st day, September 13th (Wed)Morning
9:10

10:00
1

Chair: Yusuke Ogura (The University of Tokyo)
Total Synthesis of Puberuline C(Graduate School of Pharmaceutical Sciences, The University of Tokyo)
Tsukasa Shimakawa, Shu Nakamura, Hibiki Asai, Koichi Hagiwara, Masayuki Inoue

2

Unified Total Syntheses of Longibornane Natural Products(1 UC Berkeley, 23

Graduate School of Infection

Control Sciences, Kitasato University)
Goh Sennari 1,2,3, Robert F. Lusi 1, Richmond Sarpong 1
10:00

11:15
3

Chair: Toshiyuki Wakimoto (Hokkaido University)

Structure-Function Analysis of Pyridoxal 5'-Phosphate Dependent Enzymes in theBiosynthesis of Lincosamides(1 Graduate School of Pharmaceutical Sciences, The University of Tokyo,23Graduate School of Agricultural and Life Sciences, The University of Tokyo,
Institute of Microbiology, The Czech Academy of Sciences)

Takahiro Mori 1, Kosuke Sakurada 1, Yoshitaka Moriwaki 2, Stanislav Kadlcik 3,Tohru Terada 2, Jiri Janata 3, Ikuro Abe 1
4

Unified Biogenesis of Fungal Dimeric Anhydrides: Proposal of Cyclization
Mechanism Affording Characteristic Nine-Membered Ring
(1 Faculty of Science, Hokkaido University, 2 Graduate School of Pharmaceutical Sciences,
The University of Tokyo, 3 Agriculture and Life Science, Hirosaki University,4Wuyi University)
Atsushi Minami 1, Taro Ozaki 1, Shintaro Yamamoto 1, Taro Matsuyama 2,Tetsuya Shiina 1, Ryuya Fujii 1, Yusuke Matsu 1, Junya Takino 1, Masaru Hashimoto 3,Hajime Sato 2, Masanobu Uchiyama 2, Hideaki Oikawa 1,4
5

Structural Basis for a Marine Bacterial Drimenol Synthase(RIKEN CSRS)
Keisuke Fujiyama, Hiroshi Takagi, Nhu Ngoc Quynh Vo, Shunji Takahashi

11:20

12:20

Chair: Ryo Tanifuji (The University of Tokyo)
Short Presentation 1

12:20

13:10

Lunch Breakxxi

Afternoon
13:10

14:40

Poster Discussion (P1-1

14:45

15:35

Chair: Kazuma Murakami (Kyoto University)

6P1-23)Synthesis of Manzamine Alkaloid-Type Macrocyclic Scaffold via Biomimetic
Transannular Cyclization(1 Graduate School of Science, The University of Tokyo, 2 Graduate School ofEngineering, Tokyo University of Agriculture and Technology)
Toshiaki Wayama 1, Yuta Arai 2, Hiroki Oguri 1

7

Synthetic Study of Lycopodium Alkaloids with Decahydroquinoline Scaffold(1 Graduate School of Pharmaceutical Sciences, Chiba University, 2 Graduate School ofScience and Technology, Kumamoto University)
Yuta Nakashima 1, Taichi Inoshita 2, Mariko Kitajima 1, Hayato Ishikawa 1

15:35

16:25
8Chair: Ken Ohmori (Tokyo Institute of Technology)

Asymmetric Total Synthesis of Discorhabdin B, H, K and Aluetianamine(Graduate School of Pharmaceutical Sciences, Tohoku University)

9

Masashi Shimomura, Kohta Ide, Juri Sakata, Hidetoshi Tokuyama
Total Synthesis of Indole Alkaloids by Lactam Strategy(Faculty of Science and Technology, Keio University)
Yasukazu Sugiyama, Daiki Kaneko, Yuichirou Shirakata, Seiya Katahara, Mina Yamane,
Yukinori Komiya, Noritaka Chida, Toshitaka Okamura, Takaaki Sato

16:25

17:15
10

Chair: Go Hirai (Kyushu University)

Synthetic Sudies on Muraymycin A1 and Discovery of Antimetastatic Agents(College of Pharmacy Pharmaceutical Science, University of Tennessee Health ScienceCenter)11

Katsuhiko Mitachi, Michio Kurosu
Synthetic Studies on Himalensine A Based on an Improved BCD-Ring Construction
Strategy(Graduate School of Pharmaceutical Sciences, Tohoku University)
Koki Shikama, Junpei Koyama, Hiroyuki Yamakoshi, Yusuke Sasano, Yoshiharu Iwabuchixxii

17:1518:05
12

Chair: Satoshi Yokoshima (Nagoya University)

Rapid Structural Optimization of Antibacterial Natural Products Based on Build-Up
Library Synthesis(1 Faculty of Pharmaceutical Sciences, Hokkaido University, 2 School/Faculty of Veterinary
Medicine Hokkaido University, 3 Wakunaga Pharmaceutical Co., Ltd., 4 Sapporo Medical
University, 5 Global Institution for Collaborative Research and Education (GI-CoRE))
Kazuki Yamamoto 1, Toyotaka Sato 2, Kenta Asao 1, Rintaro Kaguchi 1,Shintaro Kusaka 1, Ruddarraju Radhakrishnam Raju 1, Daichi Kazamori 3, Kiki Seo 3,
Satoshi Takahashi 4, Motohiro Horiuchi 2, Shin-ichi Yokota 4, Satoshi Ichikawa 1,513Asymmetric Total Synthesis of Histrionicotoxins Utilizing One-Step Constructionof an Azaspirocycle and Their Inhibition Activity of the Nicotinic Acetylcholine
Receptors(1 Graduate School of Science, Osaka Metropolitan University, 2 Graduate School ofAgriculture, Kindai University)
Yosuke Ono 1, Keisuke Nishikawa 1, Kunihiro Matsumura 1, Sumito Mori 2,Koichi Takayama 2, Makoto Ihara 2, Kazuhiko Matsuda 2, Yoshiki Morimoto 1

18:05

18:55
14

Chair: Kiyotake Suenaga (Keio University)

Searching for Novel Natural Product from Rare Actinomycetes Using Analysis ofSecondary Metabolite Biosynthetic Potential and Molecular Networking(1 Graduate School of Infection Control Sciences, Kitasato University, 2
Memorial Institute, 3 Rigaku Co., Ltd.)
Yuta Kikuchi 1, Yoshihiro Watanabe 1,2, Hayama Tsutsumi 1,2, Sho Ito 3,

15

Masato Iwatsuki 1,2, Yuki Inahashi 1,2
Isolation, Structure Elucidation and Synthesis of Calyxosides(Graduate School of Agricultural and Life Sciences, The University of Tokyo)
Kenji Sugawara, Hironori Okamura, Yusuke Ogura, Shigeki Matsunaga,
Hirosato Takikawa

xxiii

2nd day, September 14th (Thu)Morning
9:10

10:00
16

Chair: Satoshi Ichikawa (Hokkaido University)
Total Syntheses of Malettinins(Graduate School of Pharmaceutical Sciences, Nagoya University)
Nariyoshi Umekubo, Satoshi Yokoshima

17

Organcatalyst-Mediated, 6 Pots Synthesis of Latanoprost(Graduate School of Science, Tohoku University)
Genki Kawauchi, Yurina Suga, Shunsuke Toda, Yujiro Hayashi

10:00

11:15

Chair: Hiroki Oguri (The University of Tokyo)

18(Department of Chemistry, Tokyo Institute of Technology)
Yoshio Ando, Nozomi Tanaka, Mark Marcello Maturi, Ken Ohmori, Keisuke Suzuki
19

Total Synthesis of Aplysiasecosterols A and B, Two Marine 9,11-Secosteroids(Graduate School of Pure and Applied Sciences, University of Tsukuba)

20

Takayuki Ohyoshi, Hidetada Iizumi, Shu Hosono, Hikaru Tano, Hideo Kigoshi
Natural Glycan Conjugates Trafficking In Vivo by Chemical Reaction(1 School of Materials and Chemical Technology, Tokyo Institute of Technology,
2

Biofunctional Synthetic Chemistry Laboratory, RIKEN)

Kenshiro Yamada 1, Tatsuya Kobayashi 1, Akari Mukaimine 2, Akiko Nakamura 2,
Yuriko Kusakari 2, Ambara Rachmat Pradipta 1, Katsunori Tanaka 1,2
11:15

12:15

Chair: Taro Shiraishi (The University of Tokyo)
Short Presentation 2

12:15

13:35

Lunch Breakxxiv

Afternoon
13:35

15:05

Poster Discussion (P2-1

15:05

15:10

Advance Notice: Yoshiji Takemoto (Kyoto University)

15:15

16:05

Chair: Kenichi Matsuda (Hokkaido University)

21P2-25)

Discovery and Characterization of Fungal Depside Synthases(Department of Chemistry, City University of Hong Kong)
Lin Chen, Xingxing Wei, Qiaolin Ji, Yudai Matsuda

22

Biosynthesis of the Immunosuppressant ()-FR901483 and Self-Resistant

Mechanism in Producing Fungi(1 Department of Pharmaceutical Sciences, University of Shizuoka, 2 Department ofChemical and Biomolecular Engineering and Department of Chemistry and Biochemistry,
University of California)
Sakurako Sakano 1, Michio Sato 1, Miku Nakahara 1, Yui Tamura 1, Kodai Hara 1,Hiroshi Hashimoto 1, Yi Tang 2, Kenji Watanabe 1
16:05

16:55
23

Chair: Takayoshi Awakawa (RIKEN CSRS)

Expanding the Repertoire of Prenylation Reactions by Structure-Based Engineeringof Cyanobactin PTases(1 Graduate School of Science, The University of Tokyo, 2 Graduate School of Medicine,
Yokohama City University)
Yuchen Zhang 1, Keisuke Hamada 2, Masayuki Satake 1, Toru Sengoku 2, Yuki Goto 1,Hiroaki Suga 124Engineering Natural Products by Chem-Bio Hybrid Synthesis for Drug Discovery ofDysentery Amoebiasis(1 School of Agricultural Sciences, Nagoya University, 2 Department of PharmaceuticalSciences, University of Shizuoka, 3 Graduate School of Bioagricultural Sciences,Nagoya University, 4 Department of Nanopharmaceutical Sciences, Nagoya Institute ofTechnology, 5 Graduate School of Medicine, The University of Tokyo, 6 NIID,
7IAR., Nagoya University)
Yuki Okura 1, Namiko Ogata 2, Masaki Kita 3, Kenji Watanabe 2, Koichi Yoshinari 2,
Norio Shibata 4, Ryota Shizu 2, Mihoko Mori 5, Yuji Sumii 4, Yumiko Nakano 6,Tomoyoshi Nozaki 5, Yuta Tsunematsu 3,7xxv

16:55

17:45

Chair: Teigo Asai (Tohoku University)

25(1 Graduate School of Engineering, Hokkaido University, 2 Graduate School of Chemical
Sciences and Engineering, Hokkaido University)
Takeshi Tsunoda 1, Shunkichi Furumura 2, Haruka Yamazaki 2, Yasushi Ogasawara 1,Tohru Dairi 1
26

Streamlined Chemoenzymatic Synthesis of Cyclic Peptides by Non-Ribosomal
Peptide Cyclases(Faculty of Pharmaceutical Sciences, Hokkaido University)
Masakazu Kobayashi, Rintaro Ichihara, Naho Onozawa, Kenichi Matsuda,Toshiyuki Wakimoto

19:00

21:00Award Ceremony & Symposium Mixerxxvi

3rd day, September 15th (Fri)Morning
9:10

10:00
27

Chair: Yuki Goto (The University of Tokyo)
Identification of Ancestral Plant Hormones in M. polymorpha and Isomerization
Reaction as a Key to Hormonal Evolution(1 Graduate School of Sciences, Tohoku University, 2 School of Pharmacy, Yantai
University, 3 CNBCSIC, 4 Graduate School of Life Sciences, Tohoku University)
Takuya Kaji 1, Hidenori Yoshimatsu 1, Nobuki Kato 1, Haruka Sakurai 1, Gangqiang Yang 2,Guillermo H. Jimenez-Aleman 3, Roberto Solano 3, Minoru Ueda 1,428Viral Glycan Binding and Anti-SARS-CoV-2 Activity of Pradimicin A(1 Graduate School of Bioagricultural Sciences, Nagoya University, 2 iGCORE,
3Hiroshima University HG, 4 Hiroshima University AI, 5 CCPID, Nagasaki University,

6Biotechnology Research Center and Department of Biotechnology, Toyama PrefecturalUniversity, 7 Graduate School of Science, Osaka University)
Yu Nakagawa 1,2, Masato Fujii 1, Nanaka Ito 1, Makoto Ojika 1, Dai Akase 3, Misako Aida 4,Takaaki Kinoshita 5, Yasuteru Sakurai 5, Jiro Yasuda 5, Yasuhiro Igarashi 6, Yukishige Ito 7
10:00

11:15
29

Chair: Hayato Ishikawa (Chiba University)

Efficient Synthesis of Pseudo-Glycan with C-Glycosidic Linkage for the Creation ofNovel Bioactive Compound(1 Graduate School of Pharmaceutical Sciences, Kyushu University, 2 Faculty ofAgriculture, Setsunan University, 3 NIBIO, 4 RIMD, Osaka University, 5 RIKEN CSRS)
Takahiro Moriyama 1, Makoto Yoritate 1, Syunsuke Ono 1, Naoki Kato 2, Azusa Saika 3,Wakasa Kusuhara 4, Natsuho Moritsuho 1, Riko Tanabe 1, Minori Numamoto 2,Eri Ishikawa 4, Takahiro Nagatake 3, Noriaki Kiya 1, Hiroaki Matoba 1, Shunji Takahashi 5,Jun Kinisawa 3, Sho Yamasaki 4, Go Hirai 130

Semi-Synthesis of Homogeneous Glycoprotein via Novel Expressed Peptide
Thioesterification Methods(1 Graduate School of Sciences, Osaka University, 2 Graduate School of Science, OsakaUniversity)
Yanbo Liu 1, Kento Iritani 1, Ryo Okamoto 1,2, Yuta Maki 1,2, Yasuhiro Kajihara 1,231

Chemical Synthesis and Function of Acetic Acid Bacteria Acetobacter pasteurianus
Lipid A
(Graduate School of Science, Osaka University)
Haruki Yamaura, Atsushi Shimoyama, Koichi Fukase

11:20

12:20

Chair: Richiro Ushimaru (The University of Tokyo)
Short Presentation 3

12:20

13:10

Lunch Breakxxvii

Afternoon
13:10

14:40

Poster Discussion (P3-1

14:45

16:00

Chair: Masanori Nagatomo (The University of Tokyo)

32

Total Synthesis of (P3-26))-Cotylenol(The Scripps Research Institute)
Ryota Sato, Tucker R. Huffman, Akihiro Kuroo, Ryan A. Shenvi
33

Protecting-Group-Free Total Synthesis of Boscartins A, F, and H(Synthetic Medicinal Chemistry, Hoshi University)
Shogo Kamo, Hiroto Aihara, Daisuke Konai, Akihiko Kasamatsu, Junya Shiraiwa,Akinobu Matsuzawa, Kazuyuki Sugita

34

Asymmetric Total Synthesis of Picrotoxinin(1 Graduate School of Bioagricultural Sciences, Nagoya University, 2 Faculty of Scienceand Engineering, Iwate University)
Taishi Matsumura 1, Toshio Nishikawa 1, Atsuo Nakazaki 1,2

16:00

16:50
35

Chair: Masaki Kita (Nagoya University)

Structures of New Polyketide Paraphaeolactones: Revisions of the Absolute
Configurations of the Relevant Derivatives and Their Biosynthesis(1 Agriculture and Life Science, Hirosaki University, 2 Institute of Natural Medicine,
University of Toyama)
Ryuhi Kanehara 1, Yuki Oinuma 1, Hayato Maeda 1, Katsuhiro Konno 2, Kazuaki Tanaka 1,Masaru Hashimoto 1

36

Adaptable Hydrogen Bonding Networks Inside a Metal-Organic Framework for
Atomic-Resolution Structure Elucidation of Bioactive Compounds(Department of Chemistry, Tokyo Institute of Technology)
Yuki Wada, Pavel Usov, Yu Tagami, Yiying Zhu, Masaki Kawanoxxviii

16:50

17:40
37Chair: Hiroyuki Morita (University of Toyama)

Mycale Sponges Inherit Cytotoxin Producers through Vertical Microbial Transfer(1 School of Marine Biosciences, Kitasato University, 2 The Kuroshio Biological ResearchInstitute, 3 Graduate School of Science, Nagoya University, 4 National Institute ofAdvanced Industrial Science and Technology, 5 Graduate School of Agricultural and Life
Sciences, The University of Tokyo, 6 Graduate School of Fisheries Sciences, Hokkaido
University)
Kentaro Takada 1, Yuji Ise 2, Masashi Fukuoka 3, Nobutada Kimura 4,Kazutoshi Yoshitake 5, Akihiro Ninomiya 5, Shigeki Matsunaga 5, Ryuichi Sakai 6,Masaki Fujita 6

38

Exploring Arsenic Secondary Metabolic Pathway in Actinomycetes Based on Novel
C-As Bond Formation Reaction(Faculty of Science, Gakushuin University)
Shotaro Hoshino, Shumpei Asamizu, Hiroyasu Onaka

17:40

18:30
39

Chair: Kenji Watanabe (University of Shizuoka)

Functional Analysis and Engineering of a Polyketide Synthase in the Biosynthesis ofMacrolide Antibiotics Produced by Streptomyces graminofaciens A-8890(1 Department of Chemistry, Tokyo Institute of Technology, 2 Department of Life
Science and Technology, Tokyo Institute of Technology, 3 Graduate School of Lifeand Environmental Sciences, University of Tsukuba, 4 Japan Biological Informatics
Consortium, 5 National Institute of Advanced Industrial Science and Technology)
Taichi Chisuga 1, Kosuke Kishikawa 1, Akira Nagai 1, Kazuma Tsuboi 1,
Satoshi Murakami 2, Takeo Usui 3, Junko Hashimoto 4, Kazuo Shin-ya 5,Akimasa Miyanaga 1, Fumitaka Kudo 1, Tadashi Eguchi 140

Complete Biosynthesis of the Non-Proteinogenic Amino Acid Cispentacin inActinomycetes(1 Graduate School of Agricultural and Life Sciences, The University of Tokyo,
2
CRIIM, The University of Tokyo)
Genki Hibi 1, Taro Shiraishi 1,2, Tatsuki Umemura 1, Makoto Nishiyama 1,2,Tomohisa Kuzuyama 1,2xxix