The 20th Sapporo Symposium on Biological Rhythm in 2022
(The 10th Anniversary Meeting of the newly established foundation)

Aug 12 (Fri) at Keio Plaza Hotel Sapporo
13:00 Opening Address: Ken-ichi Honma
13:05 Awarding Lecture (online)
Amita Sehgal (University of Pennsylvania, Philadelphia, USA)

From clock genes to circadian physiology and disease
14:00 Laudatory Address: Johanna Meijer
14:15 Memorial Symposium: Circadian Rhythm and Sleep
Chairpersons: R. Silver, Y. Shigeyoshi
Kazuhiko Kume (Nagoya City University, Nagoya, JPN)

Distinct dopaminergic pathways converge and regulate arousal in the centralcomplex of Drosophila
Arisa Hirano (University of Tsukuba, Tsukuba, JPN)

Molecular and neuronal mechanism underlying the orexinergic signaling inregulation of sleep-wake behavior
Hiroki Ueda (University of Tokyo, Tokyo, JPN)

Systems biology of mammalian sleep/wake cycles: phosphorylation hypothesis ofsleep
Johanna Meijer (Leiden University Medical School, Leiden, The Netherlands)

Principles of photic entrainment in nocturnal and diurnal rodents
17:00 Memorial Lecture
Chairperson : Takashi Yoshimura
Carl Johnson (Vanderbilt University, Nashville, USA)

Scintilla of Circadian Evolution

Aug 13 (Sat) at International Conference of Hokkaido University
09:00 – 12:00 Symposium (1): Circadian Clock and External Periodicities
Chairpersons: S. Yasuo, H. OsterRalph Mistlberger (Dimon Fraser University, Burnaby, Canada)

The organization of a circadian timekeeping system for prediction mealtimes
Megumi Hatori (Nagoya University, Nagoya, JPN)

Effects of time-restricted eating on the energy metabolism in mice and non-humanprimates
Yujiro Yamanaka (Hokkaido University, Sapporo, JPN)

Restricted meal schedule prevents free-running of sleep-wale cycle but notcircadian pacemaker in humans
Wataru Nakamura (Nagasaki University, Nagasaki, JPN)

A functional analysis of circadian pacemakers in Per-less mice
12:00-13:30: Lunchon Poster
13:30 – 14:30: Plenary lecture (1)Chairperson: S. Honma
Martha Merrow (LMU, Munich, Germany)

Reflections on principle and properties of circadian clocks
14:30 – 17:30 Symposium (2): Circadian Clock and Functions
Chairpersons: A. Hirano, R. Mistlberger
Henrik Oster (University of Lubeck, Lubeck, Germany)

Circadian clocks and food intake – there and back again
Naohiro Kon (Nagoya University, Nagoya, JPN)

Roles of Ca2+ signaling in molecular clocks
Tsuyoshi Hirota (Nagoya University, Nagoya, JPN)

Regulation of mammalian Cryptochrome with small molecule compounds from invitro to in vivo
Kazuhiro Yagita (Kyoto Prefectural University of Medicine, Kyouto, JPN)

Rhythm switching and emergence of the circadian time order in mammals
18:30 – 21:00: Get-together Party at Keio-Plaza Hotel Sapporo

Aug. 14 (Sun) at International Conference of Hokkaido University
09:00 – 12:00 Symposium (3): Mechanisms of Circadian Clock
Chairpersons: M. Hatori, K. Kume
Michael Hastings (Medical Research Council Laboratory of Molecular Biology,Cambridge, UK)
Molecular genetics of the role of Cryptochromes in the circadian clock of thesuprachiasmatic nucleus (Online)
Hikari Yoshitane (Tokyo Metropolitan Institute of Medical Science, Tokyo, JPN)

Circadian quartz: Implication for protein oscillator in mammalian circadianclockwork
Sinobu Yasuo (Kyushu University, Fukuoka, JPN)Internal desynchrony in mice under social jetlag-like condition
Masao Doi (Kyoto University, Kyoto)

Circadian intracrine activity governs age-associated meibomian gland dysfunctionand evaporative dry eye disease
12:00 – 13:30: Lunchon Poster
13:30 – 14:30: Plenary lecture (2)Chairperson: Kondo Takao
Ken-ichi Honma (Hokkaido University, Sapporo, JPN)

A decade of the Aschoff and Honma Memorial Foundation
14:30 – 17:30: Symposium (4): SCN Structure and Functions
Chairperson: J. Meijer, Y. Fukada
Rae Silver (Barnard College of Columbia University, New York, USA)

Vascular and neuroendocrine aspects of SCN structure and function
Yasufumi Shigeyoshi (Kindai University, Osaka, JPN)

Small regional oscillators in the suprachiasmatic nucleus, the machinery to obtain
adaptation to the environmental light changes
Michihiro Mieda (Kanazawa University, Kanazawa, JPN)

Critical roles of AVP neurons in the control circadian clock of the SCN network
Sato Honma (Sapporo Hanazono Hospital, Sapporo, JPN)

Multi-oscillator system in the suprachiasmatic nucleus: Democracy vs. autocracy
for the stability and adaptability of the circadian pacemaker
17:45 Closing Remark: Ken-ichi Honma