Curriculum Vitae Yoshihiko Ito
Office: Assistant Professor, Department of Pharmacokinetics and Phrmacodynamics,
School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada,Suruga-ku, Shizuoka 422-8526, Japan
Tel: +81-54-264-5634, Fax: +81-54-264-5635,
e-mail: y-ito@u-shizuoka-ken.ac.jp
Education:
B.Sc.

in

Pharmacy,Dept.

ofPharmacology,

SchoolofPharmaceutical Sciences, University of Shizuoka, April 1998
– March 2002
M.Sc.

in

Pharmacy,Dept.

ofPharmacology,

SchoolofPharmaceutical Sciences, University of Shizuoka, April 2002
– March 2004
Ph. D.

inPharmacy,

Dept.

ofPharmacology,

SchoolofPharmaceutical Sciences, University of Shizuoka, April 2004
– March 2007
Mentor: K. Nakayama, Ph. D. and T. Ishikawa, Ph.D.
Dissertation:“Intracellularmechanismsofpassive

stretch-induced glucose uptake in skeletal muscles”
Postgraduate Training, Research and Staff Appointments:
April 2007 – present: Research Fellow (Assistant professor), Dept. ofPharmacology, School of Pharmaceutical Sciences,
University of Shizuoka
Bibliography:
1.

Yoshihiko Ito, Aya Kato, Tomomi Fujino (Oki), Takashi Okura, KenichiroYoshida, Masato Nanri and Shizuo Yamada: Muscarinic receptor binding andplasma drug concentration after the oral administration of propiverine in mice
LUTS, 2: 43-49 (2010)2.

Shizuo Yamada, Yoshihiko Ito, Yuko Taki, Masanao Seki, Masato Nanri, Fumiaki
Yamashita, Kayo Morishima, Ikumi Komoto, and Ken-ichiro Yoshida: The

N-oxide metabolite contributes to bladder selectivity resulting from oral
propiverine: muscarinic receptor binding and pharmacokinetics.
Drug Metab. Dis.. 38: 1314-1321 (2010)3.

Yoshihiko Ito, Taketsugu Harada, Kasumi Fushimi, Yoshiyuki Kagawa, Hidenobu
Oka, Hiroshi Nakazawa, Reiko Homma, Yoshihisa Kato and Shizuo Yamada:
Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition
by distigmine bromide in rats
Drug Metab. Phamacokinet., 25: 254-261(2010)

4.

Akira Yoshida, Shuji Maruyama, Dai Fukumoto, Hideo Tsukada, Yoshihiko Itoand Shizuo Yamada: Noninvasive evaluation of brain muscarinic receptor
occupancy of oxybutynin, darifenacin and imidafenacin in rats by positronemission tomography
Life Sci., 25: 175-180 (2010)

5.

Mizuki Watanabe, Takatsugu Hirokawa, Takaaki Kobayashi, Akira Yoshida,
Yoshihiko Ito, Shizuo Yamada, Naoki Orimoto, Yasundo Yamasaki, Mituhiro
Arisawa and Satoshi Shuto: Investigation of the bioactive conformation ofhistamine

H3

receptor

antagonists

bythecyclopropylic

strain-based

conformational restriction strategy.
J. Med. Chem., 53: 3585-3593 (2010)
6.

Takaaki Kobayashi, Mizuki Watanabe, Akira Yoshida, Shizuo Yamada, Mika Ito,Hiroshi Abe, Yoshihiro Ito, Mituhiro Arisawa and Satoshi Shuto: Synthesis andstructural and pharmacological properties of cyclopropane-based conformationallyrestricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.
Bioorg. Med. Chem., 18: 1076-1082 (2010)7.

Yoshihisa Kato, Hiroshi Suzuki, Koichi Haraguchi, Shinichi Ikushiro, YoshihikoIto, Shinya Uchida, Shizuo Yamada and Masakuni Degawa: A possible mechanism
for the decrease in serum thyroxin level by phenobarbital in rodents.
Toxicol. Appl. Pharmacol., 249: 238-246 (2010)

8.

Kazuo Obara, Ayako Mitate, Kayo Nozawa, Makiko Watanabe, Yoshihiko Ito andKoichi Nakayama: Interactive role of protein phosphatase 2A and protein kinase
Cα in the stretch-induced triphosphorylation of myosin light chain in caninecerebral artery.
J. Vasc. Res. 47: 115-127(2010)9.

Yoshihiko Ito, Luvsandorj Oyunzul, Masanao Seki, Tomomi Fujino(Oki), Minoru
Matsui and Shizuo Yamada: Quantitative analysis of the loss of muscarinic
receptors in various peripheral tissues in M1-M5 single subtype knockout mice
Br. J. Pharmacol., 156, 1147-1153 (2009)

10. Shizuo Yamada, Chihiro Takeuchi, Luvsandorj Oyunzul and Yoshihiko Ito:
Bladder angiotensin-II receptors: Characterization and alteration in bladder outlet
obstruction.
Ｅｕｒ. Urol., 55, 482-489 (2009)
11. Shohei Kurosawa, Shinya Uchida Yoshihiko Ito and Shizuo Yamada: Effect ofursodeoxycholic acid on the pharmacokinetics and midazolam and CYP3A activity
in the liver and small intestine of rats.
Xenobiotica, 39: 162-170 (2009)
12. Takashi Okura, Yuki Morita, Yoshihiko Ito, Yoshiyuki Kagawa and Shizuo
Yamada: Effects of quinidine on antinociception and pharmacokinetics ofmorphine in rats.
J. Pharm. Pharmacol., 61: 593-597 (2009)
13. Masayuki Abe, Yoshihiko Ito, Luvsandorj Oyunzul., Tomomi Oki-Fujino andShizuo Yamada: Pharmacologically relevant receptor binding characteristics and5a-reducatase inhibitory activity of free fatty acids contained in Saw palmetto
extract.
Biol. Pharm. Bull., 32: 646-650 (2009)
14. Masayuki Abe, Yoshihiko Ito, Asahi Suzuki, Satomi Onoue, Hiroshi Noguchi andShizuo Yamada: Isolation and pharmacological characterization of fatty acids fromSaw palmetto extract.
Anal. Sci., 25: 553-557 (2009)
15. Yoshihiko Ito, Luvsandorj Oyunzul, Akira Yoshida, Tomomi Fujino, Yukiko
Noguchi, Hronori Yuyama, Akiyoshi Ohtake, Masanori Suzuki, Masao Sasamata,Minoru Matsui and Shizuo Yamada: Comparison of muscarinic selectivity ofsolifenacin and oxybutynin in the bladder and submandibular gland of muscarinic
receptor knockout mice.
Eur. J. Pharmacol., 615: 201-206 (2009)16. Yoshihiko Ito, Masanao Seki, Yasuhiko Nishioka, Masatoshi Kimura, Akio
Yasuda,Tsukasa

Kirimoto,

Toshikazu

YasudaandShizuo

Yamada:Pharmacological effects of Hashi-mi-jio-gan extract (Harncare) on the contractile
response and on pharmacologically relevant receptors in the rat bladder.
YAKUGAKU ZASSHI, 129: 957-964 (2009)
17. Mayumi Suzuki, Yoshihiko Ito, Tomomi Fujino, Masayuki Abe, Keizo Umegaki,
Satomi Onoue, Hiroshi Noguchi and Shizuo Yamada: Pharmacological effects ofsaw palmetto extract in lower urinary tract. (Invited review).
Acta Pharmacol Sin, 30: 271-281 (2009)18. Daiki Takahashi, Luvsandorj Oyunzul, Satomi Onoue, Yoshihiko Ito, ShinyaUchida, Rahime Simsek, Miyase Gozde Gunduz, Chiat Safak, and Shizuo
Yamada:Structure-activityrelationshipsofreceptor

bindingof1,4-dihydropyridine derivatives.
Biol. Pham. Bull., 31, 473-479 (2008)
19. Aiko Kageyama, Tomomi Fujino, Yuko Taki, Yoshihisa Kato, Yoshihisa Nozawa,
Yoshihiko Ito and Shizuo Yamada: Alteration of muscarinic and purinergic
receptors in urinary bladder of rats with cyclophosphamide-induced interstitialcystitis.
Neurosci. Lett., 436, 81-84 (2008)
20. Takashi Okura, Tadahiro Ozawa, Yoshihiko Ito, Midori Kimura, Yoshiyuki
Kagawa and Shizuo Yamada: Enhancement by grapefruit juice of morphine
antinociception.
Biol. Pharm. Bull., 31, 2338-2341 (2008)
21. Kazuo Obara, Yoshihiko Ito, Hiroyuki Shimada and Koichi Nakayama: Therelaxant effect of okadaic acid on canine basilar artery involves activation ofPKCalpha and phosphorylation of the myosin light chain at Thr-9.
Eur. J. Pharmacol., 598, 87-93 (2008)
22. Yoshihiko Ito, Kazuo Obara, Rikuko Ikeda, Megumi Ishii, Yoshiyuki Tanabe,Tomohisa Ishikawa, Koichi Nakayama: Passive stretching produces Akt- andMAPK-dependent augmentations of GLUT4 translocation and glucose uptake inskeletal muscles of mice.
Pflügers Arch., 451, 803-813 (2006)