CURRICULUM VITAE
Tomohisa ISHIKAWA
Date of birth:

December 29, 1960

Nationality:

Japanese

ADDRESS
Department of Pharmacology
School of Pharmaceutical Sciences
University of Shizuoka
52-1 Yada, Suruga Ward, Shizuoka City, Shizuoka 422-8526, Japan
Phone +81-54-264-5694
Fax+81-54-264-5696

E-mail ishikat@u-shizuoka-ken.ac.jp
https://w3pharm.u-shizuoka-ken.ac.jp/pharmaco/
EDUCATION
1989

Ph.D. in Pharmacology, University of Tsukuba, Ibaraki, Japan
Thesis: " Positive inotropic effect of calcitonin gene-related peptide mediatedby cyclic AMP in guinea pig heart."

1986

M.S. in Pharmacology, University of Tsukuba, Ibaraki, Japan

1984

B.S. in Pharmaceutical Sciences, Tokyo University of Science, Tokyo, JapanAPPOINTMENTS
2023-present

Dean, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka,Japan

2019-2023

Dean, Graduate Division of Pharmaceutical Sciences,
University of Shizuoka, Shizuoka, Japan

2019-2021

Dean, Graduate School of Integrated Pharmaceutical and Nutritional Sciences,
University of Shizuoka, Shizuoka, Japan

2015-2019

Vice dean, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka,Japan

2006-present

Professor, Department of Pharmacology, University of Shizuoka, Shizuoka,
Japan

1998-2006

Associate Professor, Department of Pharmacology, University of Shizuoka,
Shizuoka, Japan1

1994-1998

Assistant Professor, Department of Pharmacology, University of Tsukuba,
Ibaraki, Japan

1993-1994

Research Assistant Professor, Department of Physiology, University of Nevada,NV, U.S.A.

1990-1993

Research Associate, Department of Physiology, University of Nevada, NV,
U.S.A.

1990-1991

Assistant Professor, Department of Pharmacology, University of Tsukuba,
Ibaraki, JapanRESEARCH INTEREST
Signaling molecules involved in the functional regulation of pancreatic β-cells
Signaling mechanisms involved in the activation and deactivation of hepatic stellate cells
SOCIETY MEMBERSHIPSThe Japanese Pharmacological Society
Pharmaceutical Society of Japan
Japanese Association of Cardiovascular Pharmacology
Japan Diabetes Society
PUBLICATIONS
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Kaji M, Kaneko YK, Ihim SA, Kanoh R, Yamamoto M, Yamaguchi M, Ishikawa T. Oral ingestionof Shiikuwasha extract suppresses diabetes progression in db/db mice by preserving β-cell mass.
Front Nutr. 2024; 10: 1336133. doi: 10.3389/fnut.2023.1336133.
Kodera S, Kimura T, Nishioka T, Kaneko YK, Yamaguchi M, Kaibuchi K, Ishikawa T. GDPbound Rab27a regulates clathrin disassembly through HSPA8 after insulin secretion. Arch
Biochem Biophys. 2023; 749, 109789. doi: 10.1016/j.abb.2023.109789.
Kato M, Yamaguchi M, Ooka A, Takahashi R, Suzuki T, Onoda K, Yoshikawa Y, Tsunematsu Y,
Sato M, Yoshioka Y, Igarashi M, Hayakawa S, Shoji K, Shoji Y, Ishikawa T, Watanabe K,
Miyoshi N. Non-target GC-MS analyses of fecal VOCs in NASH-hepatocellular carcinoma
model STAM mice. Sci Rep. 2023; 13: 8924. doi: 10.1038/s41598-023-36091-7.
Ishida H, Ishikawa T, Saito SY. Enhanced contraction of arterial smooth muscle cell in skin arteryis sensitive to hyperpolarization mediated by BKCa channel in chronic constriction injury model
rat. Biol Pharm Bull. 2023; 46: 399-403. doi: 10.1248/bpb.b22-00603.
Ihim SA, Kaneko YK, Yamamoto M, Yamaguchi M, Kimura T, Ishikawa T. Apigenin alleviates
endoplasmic reticulum stress-mediated apoptosis in INS-1 β-cells. Biol Pharm Bull. 2023; 46:
630-635. doi: 10.1248/bpb.b22-00913.
Yamaguchi M, Ohbayashi S, Ooka A, Yamashita H, Motohashi N, Kaneko YK, Kimura T, Saito
SY, Ishikawa T. Harmine suppresses collagen production in hepatic stellate cells by inhibiting
DYRK1B. Biochem Biophys Res Commun. 2022; 600: 136-141. doi: 10.1016/j.bbrc.2022.02.054.
Yamaguchi M, Kanazawa T, Morino S, Iioka S, Watanabe Y, Dohi N, Higashi K, Kondo H,
Ishikawa T. Increased tropism of extracellular vesicles derived from palmitic acid-treatedhepatocytes to activated hepatic stellate cells. Membranes. 2022; 12: 1023. doi:
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10.3390/membranes12101023.
Kaneko YK, Tara Y, Ihim SA, Yamamoto M, Kaji M, Ishikawa T. Nobiletin ameliorates glucose
tolerance by protecting against β-cell loss in type-2 diabetic db/db mice. Phytomed Plus 2022; 2:100367. doi: 10.1016/j.phyplu.2022.100367.
Kaneko YK, Morioka A, Sano M, Tashiro M, Watanabe N, Kasahara N, Nojiri M, Ishiwatari C,
Ichinose K, Minami A, Suzuki T, Yamaguchi M, Kimura T, Ishikawa T. Asymmetric
dimethylarginine accumulation under hyperglycemia facilitates β-cell apoptosis via inhibiting
nitric oxide production. Biochem Biophys Res Commun. 2022; 637: 108-116. doi:
10.1016/j.bbrc.2022.11.011.
Yamaguchi M, Ohbayashi S, Ooka A, Yamashita H, Motohashi N, Kaneko YK, Kimura T, Saito
SY, Ishikawa T. Harmine suppresses collagen production in hepatic stellate cells by inhibiting
DYRK1B. Biochem Biophys Res Commun. 2022; 600: 136-141. doi: 10.1016/j.bbrc.2022.02.054.
Sato T, Ishiwatari C, Kaneko YK, Ishikawa Y, Kimura Y, Watanabe N, Aoshima I, Matsuda Y,
Nakayama T, Chiba R, Fujinuki T, Iwata K, Lu Q, Usuki T, Sakane F, Ishikawa T. Diacylglycerol
kinase δ functions as a proliferation suppressor in pancreatic β-cells. FASEB J. 2021; 35: e21420.
doi: 10.1096/fj.202001279RR.

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Dohi N, Yamaguchi M, Hase R, Suzuki R, Wakabayashi Y, Nishiyama R, Saito S, Ishikawa T.
Quantitative real-time measurement of endothelin-1-induced contraction in single non-activatedhepatic stellate cells. PLOS ONE. 2021; 16: e0255656. doi: 10.1371/journal.pone.0255656.
Yamaguchi M, Dohi N, Ooka A, Saito S, Ishikawa T. Caffeine-induced inversion of prostaglandin
E2 effects on hepatic stellate cell activation. Biomed Pharmacother. 2021; 142: 111989. doi:
10.1016/j.biopha.2021.111989.
Ishida H, Yamaguchi M, Saito SY, Furukawa T, Shannonhouse JL, Kim YS, Ishikawa T. Na+dependent inactivation of vascular Na+/Ca2+ exchanger responsible for reduced peripheral bloodflow in neuropathic pain model. Eur J Pharmacol. 2021; 910: 174448. doi:
10.1016/j.ejphar.2021.174448.
Minami, A., Fujita, Y., Shimba, S. Shiratori M, Kaneko YK, Sawatani T, Otsubo T, Ikeda K,
Kanazawa H, Mikami Y, Sekita R, Kurebayashi Y, Takahashi T, Miyagi T, Ishikawa T, Suzuki T.
The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent
potentiator of insulin secretion. Sci Rep. 2020; 10: 5198. doi: 10.1038/s41598-020-62203-8
Wada Y, Kondo M, Sakairi K, Nagashima A, Tokita K, Tominaga H, Tomiyama H, Ishikawa T.
Renoprotective effects of a novel receptor-interacting protein kinase 2 inhibitor, AS3334034, in
uninephrectomized adriamycin-induced chronic kidney disease rats. J Pharmacol Exp Ther. 2020;
374: 428–437. doi: 10.1124/jpet.120.265678.
Ishida H, Saito S, Horie A, Ishikawa T. Alleviation of mechanical stress-induced allodynia byimproving blood flow in chronic constriction injury mice. Eur J Pharmacol. 2019; 849: 67-74.
doi: 10.1016/j.ejphar.2019.02.002
Sawatani T, Kaneko YK, Doutsu I, Ogawa A, Ishikawa T. TRPV2 channels mediate insulin
secretion induced by cell swelling in mouse pancreatic β-cells. Am J Physiol Cell Physiol. 2019;
316: C434-C443. doi: 10.1152/ajpcell.00210.2017.
Sawatani T, Kaneko YK, Ishikawa T. Dual effect of reduced type I diacylglycerol kinase activity
on insulin secretion from MIN6 β-cells. J Pharmacol Sci. 2019; 140: 178-186. doi:
10.1016/j.jphs.2019.06.001.
Yamaoka M, Terabayashi T, Nishioka T, Kaibuchi K, Ishikawa T, Ishizaki T, Kimura T. IRR is
involved in glucose-induced endocytosis after insulin secretion. J Pharmacol Sci. 2019; 140: 300304. doi: 10.1016/j.jphs.2019.07.002.
Ishida H, Saito SY, Dohi N, Ishikawa T. Mechanism of Membrane Depolarization Involved in
α1A-adrenoceptor-mediated contraction in rat tail and iliac arteries. Biol Pharm Bull. 2019; 42:
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1741-1745. doi: 10.1248/bpb.b19-00473.
Furukawa S, Yamaguchi M, Ooka A, Kikuchi H, Ishikawa T, Saito SY. Differentiation-inducing
factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation. Biochem
Biophys Res Commun. 2019; 520: 140-144. doi: 10.1016/j.bbrc.2019.09.117.
Kimura T, Yamaoka M, Terabayashi T, Kaibuchi K, Ishikawa T, Ishizaki T. GDP-bound Rab27a
dissociates from the endocytic machinery in a phosphorylation-dependent manner after insulin
secretion. Biol Pharm Bull. 2019; 42: 1532-1537. doi: 10.1248/bpb.b19-00242.
Ishida H, Saito S, Hishinuma E, Kitayama T, Ishikawa T. Differential contribution of calcium
channels to α1-adrenoceptor-mediated contraction is responsible for diverse responses to coolingbetween rat tail and iliac arteries. Eur J Pharmacol. 2018; 826: 9-16. doi:
10.1016/j.ejphar.2018.02.023.
Sagara H, Kanakogi M, Tara Y, Ouchi H, Kimura J, Kaneko Y, Inai M, Asakawa T, Ishikawa T,
Kan T. Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biologicalevaluations. Tetrahedron Lett. 2018; 59: 1816-1818. doi: 10.1016/j.tetlet.2018.03.064.
Ishida H, Saito S, Ishikawa T. α1A-Adrenoceptors, but not α1B- or α1D-adrenoceptors,
contribute to enhanced contractile response to phenylephrine in cooling conditions in the rat tailartery. Eur J Pharmacol. 2018; 838: 120-128. doi: 10.1016/j.ejphar.2018.09.004
Serizawa I, Iwasaki N, Ishida H, Saito S, Ishikawa T. G-protein coupled estrogen receptormediated non-genomic facilitatory effect of estrogen on cooling-induced reduction of skin bloodflow in mice. Eur J Pharmacol 2017; 797: 26–31.
Ishida H, Saito S, Hishinuma E, Ishikawa T. Differential contribution of nerve-derived
noradrenaline to high K+-induced contraction depending on type of artery. Biol Pharm Bull 2017;40: 56–60.
Sato T, Kaneko YK, Sawatani T, Noguchi A, Ishikawa T. Obligatory role of early Ca2+ responses
in H2O2-induced β-cell apoptosis. Biol Pharm Bull 2015; 38, 1599–1605.
Kaneko YK, Takii M, Kojima Y, Yokosawa H, Ishikawa T. Structure-dependent inhibitory effects
of green tea catechins on insulin secretion from pancreatic β-cells. Biol Pharm Bull 2015; 38:
476–481.
Ishikawa T. Recent progress in the research of insulin secretion. Biol Pharm Bull 2015; 38: 655.
Kaneko YK, Ishikawa T. Diacylglycerol signaling pathway in pancreatic β-cells: An essential roleof diacylglycerol kinase in the regulation of insulin secretion. Biol Pharm Bull 2015; 38: 669–673.
Sato T, Kaneko YK, Sawatani T, Noguchi A, Ishikawa T. Obligatory role of early Ca2+ responses
in H2O2-induced β-cell apoptosis. Biol Pharm Bull 2015; 38: 1599–1605.
Goto K, Saito S, Ishikawa T. Enhanced vasoconstriction to α1-adrenoceptor stimulation duringcooling in mouse cutaneous plantar arteries. Eur J Pharmacol 2014; 742: 1–7.
Honda M, Komatsu R, Isobe T, Tabo M, Ishikawa T. Involvement of the autonomic nervous
system in diurnal variation of corrected QT intervals in common marmosets. J Pharmacol Sci
2013; 121: 131–137.
Kaneko YK, Kobayashi Y, Motoki K, Nakata K, Miyagawa S, Yamamoto M, Hayashi D, Shirai Y,
Sakane F, Ishikawa T. Depression of type I diacylglycerol kinases in pancreatic β-cells from malemice results in impaired insulin secretion. Endocrinology 2013; 154: 4089–4098.
Sahara Y, Saito S, Ishikawa T. Involvement of nitric oxide production in the impairment of skinblood flow response to local cooling in diabetic db/db mice. Eur J Pharmacol 2013; 720: 147–
179.
Kaneko YK, Ishikawa T. Dual role of nitric oxide in pancreatic β-cells. J Pharmacol Sci 2013;
123: 295–300.

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Yoshimura T, Ito A, Saito S, Takeda M, Kuriyama H, Ishikawa T. Calcitonin ameliorates
enhanced arterial contractility after chronic constriction injury of the sciatic nerve in rats.
Fundam Clin Pharmacol 2012; 26: 315–321.
Suzuki K, Saito S, Ishikawa T. Involvement of phosphatidylcholine–specific phospholipase C inthromboxane A2 receptor-mediated extracellular Ca2+ influx in rat aorta. Eur J Pharmacol 2012;
677: 123–130.
Nakayama K, Tanabe Y, Obara K, Ishikawa T. Mechanosensitivity of Pancreatic β-cells,
Adipocytes, and Skeletal Muscle Cells: The Therapeutic Targets of Metabolic Syndrome. In:
Mechanically Gated Channels and their Regulation. Kamkin A, Lozinsky I (eds), 2012; p379–
404, Springer.
Takada M, Noguchi A, Sayama Y, Kaneko Y, Ishikawa T. IP3 receptor-mediated initial Ca2+
mobilization constitutes a triggering signal for H2O2-induced apoptosis in INS-1 β-cells. Biol
Pharm Bull 2011; 34: 954–958.
Obara K, Ukai K, Ishikawa T. Mechanism of potentiation by tea epigallocatechin of contractionin porcine coronary artery: the role of protein kinase Cδ-mediated CPI-17 phosphorylation. Eur J
Pharmacol 2011; 668: 414–418.
Kashihara T, Goto K, Sahara Y, Nakayama K, Ishikawa T. Differential involvement of α1adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and invivo. J Smooth Muscle Res 2009; 45: 87–95.
Kashihara T, Nakayama K, Matsuda T, Baba A, Ishikawa T. Role of Na+/Ca2+ exchangermediated Ca2+ entry in pressure-induced myogenic constriction in rat posterior cerebral arteries. J
Pharmacol Sci 2009; 110: 218–222.
Nakayama K, Obara K, Ishikawa T, Nishizawa S. Specific mechanotransduction signaling
involved in myogenic responses of the cerebral arteries. In: Mechanosensitivity of the heart.
Kamkin A, Kiseleva I (eds), 2009; p453–9481, Springer.
Sunouchi T, Suzuki K, Nakayama K, Ishikawa T. Dual effect of nitric oxide on ATP-sensitive K+
channels in rat pancreatic β-cells. Pflügers Arch 2008; 456: 573–579.
Kashihara T, Nakayama K, Ishikawa T. Distinct roles of protein kinase C isoforms in myogenic
constriction of rat posterior cerebral arteries. J Pharmacol Sci 2008; 108: 446–454.
Noguchi A, Takada M, Nakayama K, Ishikawa T. cGMP-independent anti-apoptotic effect ofnitric oxide on thapsigargin-induced apoptosis in the pancreatic β-cell line INS-1. Life Sci 2008;
83: 865–870.
Honda M, Suzuki M, Nakayama K, Ishikawa T. Role of α2C-adrenoceptors in local coolinginduced reduction of skin blood flow in mice. Br J Pharmacol 2007; 152: 91–100.
Ito Y, Obara K, Ikeda R, Ishii M, Tanabe Y, Ishikawa T, Nakayama K. Passive stretching produces
Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake inskeletal muscles of mice. Pflügers Arch 2006; 451: 803–813.
Koganezawa T, Ishikawa T, Fujita Y, Yamashita T, Tajima T, Honda M, Nakayama K. Local
regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats. Br J
Pharmacol 2006; 148: 579–586.
Takii M, Ishikawa T, Tsuda H, Kanatani K, Sunouchi T, Kaneko Y, Nakayama K. Involvement of
stretch-activated cation channels in hypotonically induced insulin secretion in rat pancreatic βcells. Am J Physiol Cell Physiol 2006; 291: C1405–C1411.
Obara K, Nishizawa S, Koide M, Nozawa K, Mitate A, Ishikawa T, Nakayama K. Interactive roleof protein kinase Cδ with Rho-kinase in the development of cerebral vasospasm in a canine twohemorrhage model. J Vasc Res 2005; 42: 67–76.
Yano S, Ishikawa T, Tsuda H, Obara K, Nakayama K. Ionic mechanism for contractile response to
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hyposmotic challenge in canine basilar arteries. Am J Physiol Cell Physiol 2005; 288: C702–
C709.
Ishikawa T, Iwasaki E, Kanatani K, Sugino F, Kaneko Y, Obara K, Nakayama K. Involvement ofnovel protein kinase C isoforms in carbachol-stimulated insulin secretion from rat pancreatic
islets. Life Sci 2005; 77: 462–469.
Amano S, Ishikawa T, Nakayama K. Facilitation of L-type Ca2+ currents by fluid flow in rabbit
cerebral artery myocytes. J Pharmacol Sci 2005; 98: 425–429.
Ishikawa T, Kohno F, Kawase R, Yamamoto Y, Nakayama K. Contribution of nitric oxide
produced by inducible nitric oxide synthase to vascular responses of mesenteric arterioles in
streptozotocin-diabetic rats. Br J Pharmacol 2004; 141: 269–276.
Nakayama K, Obara K, Tanabe Y, Saito M, Ishikawa T, Nishizawa S. Interactive role of tyrosine
kinase, protein kinase C, and Rho/Rho kinase systems in the mechanotransduction of vascularsmooth muscles. Biorheology 2003; 40: 307–314.
Ishikawa T, Kaneko Y, Sugino F, Nakayama K. Two distinct effects of cGMP on cytosolic Ca2+
concentration of rat pancreatic β-cells. J Pharmacol Sci 2003; 91: 41–46.
Kaneko Y, Ishikawa T, Amano S, Nakayama K. Dual effect of nitric oxide on cytosolic Ca2+
concentration and insulin secretion in rat pancreatic β-cells. Am J Physiol Cell Physiol 2003; 284:
C1215–C1222.
Kiyoshi A, Ishikawa T, Hayashi K, Iwatsuki Y, Ishii K, Nakayama K. Rhythmical contractions inpulmonary arteries of monocrotaline-induced pulmonary hypertensive rats. Pflügers Arch 2003;
447: 142–149.
Nakada S, Ishikawa T, Yamamoto Y, Kaneko Y, Nakayama K. Constitutive nitric oxide synthases
in rat pancreatic islets: direct imaging of glucose-induced nitric oxide production in β-cells.
Pflügers Arch 2003; 447: 305–311.
Hayashi K, Ishikawa T, Yamashita T, Tajima T, Nakayama K. Biphasic response of cutaneous
blood flow induced by passive cutaneous anaphylaxis in rats. Eur J Pharmacol 2003; 482: 305–
311.
Nakayama K, Obara K, Tanabe Y, Ishikawa T. 20-Hydroxyeicosatetraenoic acid potentiates
contractile activation of canine basilar artery in response to stretch via protein kinase Cαmediated inhibition of calcium-activated potassium channel. Adv Exp Med Biol 2003; 538: 411–
416.
Ishikawa T, Nejishima H, Imamura T, Nakayama K. Non-contribution of renin-angiotensin
system to pressor response to NG-nitro-L-arginine in dogs. Fundam Clin Pharmacol 2002; 16:
15–21.
Sugino F, Ishikawa T, Nakada S, Kaneko Y, Yamamoto Y, Nakayama K. Inhibition by nitric oxideof Ca2+ responses in rat pancreatic α-cells. Life Sci 2002; 71: 85–93.
Obara K, Koide M, Ishikawa T, Tanabe Y, Nakayama K. Protein kinase Cδ but not protein kinaseCε activity is involved in contractile potentiation by endothelin-1 in the porcine coronary artery. J
Cardiovasc Pharmacol 2000; 36: S120–S121.
Kimura M, Obara K, Sasase T, Ishikawa T, Tanabe Y, Nakayama K. Specific inhibition of stretchinduced increase in L-type calcium channel currents by herbimycin A in canine basilar arterial
myocytes. Br J Pharmacol 2000; 130: 923–931.
Saitou T, Ishikawa T, Obara K, Nakayama K. Characterization of whole-cell currents elicited bymechanical stimulation of Xenopus oocytes. Pflügers Arch 2000; 440: 858–8651.
Matsuura N, Ishikawa T, Abe S, Yuyama H, Sugino F, Ishii K, Nakayama K. Nitric oxide-cyclic
GMP system potentiates glucose-induced rise in cytosolic Ca2+ concentration in rat pancreatic βcells. Life Sci 1999; 65: 1515–1522.
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Nakayama K, Fukuta Y, Kiyoshi A, Y. Iwatuki, Ishii K, Ishikawa T, Iida M, Iwata H, Enomoto M.
(+)-[3H]Isradipine and [3H]glyburide bindings to heart and lung membranes from rats withmonocrotaline-induced pulmonary hypertension. Jpn J Pharmacol 1999; 81: 176–184.
Tanaka M, Ishikawa T, Nishikawa T, Goto K, Sato S. Influence of acidosis on cardiotonic effectsof milrinone. Anesthesiology 1998; 88: 725–734.
Yamanaka A, Ishikawa T, Goto K. Endothelium–dependent relaxation independent of NO,
prostaglandins and epoxyeicosatrienoic acids in guinea pig coronary artery. J Pharmacol Exp
Ther 1998; 285: 480–489.
Tomobe YI, Ishikawa T, Goto K. Enhanced endothelium-independent vasodilator response tocalcitonin gene-related peptide in the mesenteric artery of spontaneously hypertensive rats. Eur J
Pharmacol 1998; 351: 351–355.
Yamada M, Ishikawa T, Fujimori A, Miyauchi T, Goto K. Enhanced depressor and hyperemic
responses to calcitonin gene-related peptide in spontaneously hypertensive rats. Peptides 1998;
19: 697–701.
Ishikawa T, Eckman DM, Keef KD. Characterization of delayed rectifier K+ currents in coronary
artery cells near resting membrane potential. Can J Physiol Pharmacol 1997; 75: 1116–1122.
Yamada M, Ishikawa T, Fujimori A, Goto K. Local neurogenic regulation of rat hindlimb
circulation: Release of vasodilator peptide, calcitonin gene-related peptide, after skeletal muscle
contraction. Br J Pharmacol 1997; 122: 703–709.
Yamada M, Ishikawa T, Yamanaka A, Fujimori A, Goto K. Local neurogenic regulation of rat
hindlimb circulation: CO2-induced release of vasodilator peptide, calcitonin gene-related peptide,from sensory nerves. Br J Pharmacol 1997; 122: 710–714.
Khoyi MA, Ishikawa T, Keef KD, Westfall DP. Ca2+-induced inhibition of 45Ca2+ influx and Ca2+
current in smooth muscle of the rat vas deferens. Am J Physiol 1996; 270: C1468–C1477.
Miyauchi T, Tomobe Y, Ishikawa T, Goto K, Sugishita Y. Vasoconstriction by endothelin-1 inresistance and conduit portions of isolated human mesenteric arteries. Eur J Pharmacol 1996;
303: 193–196.
Miyauchi T, Tomobe Y, Ishikawa T, Goto K, Sugishita Y. Calcitonin gene-related peptide (CGRP)
induces more potent vasorelaxation in the resistance portion than in the conduit portion ofmesenteric arteries in humans. Peptides 1996; 17: 877–879.
Ishikawa T, Hume JR, Keef KD. Modulation of K+ and Ca2+ channels by histamine H1 receptor
stimulation in rabbit coronary artery cells. J Physiol (Lond) 1993; 468: 379–400.
Gelband CH, Ishikawa T, Post JM, Keef KD, Hume JR. Intracellular divalent cations block
smooth muscle K+ channels. Circ Res 1993; 73: 24–34.
Ishikawa T, Hume JR, Keef KD. Differential modulation of Ca2+ channels by cAMP and cGMP in
non-dialyzed vascular smooth muscle cells. Circ Res 1993; 73: 1128–1137.
Ishikawa S, Tsukada H, Yuasa H, Fukue M, Wei S, Onizuka M, Miyauchi T, Ishikawa T, Mitsui K,
Goto K, Hori M. Effects of endothelin-1 and conversion of big endothelin-1 in the isolated
perfused rabbit lung. J Appl Physiol 1992; 72: 2387–2392.
Tomobe Y, Ishikawa T, Yanagisawa M, Kimura S, Masaki T, Goto K. Mechanisms of increased
sensitivity to endothelin-1 in aortic smooth muscle of spontaneously hypertensive rats. J
Pharmacol Exp Ther 1991; 257: 555–561.
Ishikawa T, Li L, Shinmi O, Kimura S, Yanagisawa M, Goto K, Masaki T. Characteristics ofbinding of endothelin-1 and endothelin-3 to rat hearts: developmental changes in mechanicalresponses and receptor subtypes. Circ Res 1991; 69: 918–926.
Gelband CH, Carl A, Post JM, Bowen SM, Ishikawa T, Keef KD, Sanders KM, Hume JR. Effectof cromakalim and lemakalim on whole-cell and single channel K+ currents in canine colonic,
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renal and coronary smooth muscle cells. In: Ion Channels of Vascular Smooth Muscle Cells andEndothelial Cells. Sperelakis N, Kuriyama H (eds), 1991; p125–138, Elsevier Science Publishing.
Miyauchi T, Tomobe Y, Shiba R, Ishikawa T, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K,
Masaki T. Involvement of endothelin in the regulation of human vascular tonus: potent
vasoconstrictor effect and existence in endothelial cells. Circulation 1990; 81: 1874–1880.
Ishikawa T, Yanagisawa M, Goto K, Masaki T. Effects of endothelin on neonatal and adult rat
hearts. In: Developmental Cardiology: Morphogenesis and Function. Clark EB, Takao A (eds),
1990; p 375–379, Futura Publishing.
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K. Involvement of calcitonin gene-related
peptide in the positive chronotropic and inotropic effects of piperine and development of cross
tachyphylaxis between piperine and capsaicin in the isolated rat atria. J Pharmacol Exp Ther
1989; 248: 816–824.
Li L, Ishikawa T, Miyauchi T, Yanagisawa M, Kimura S, Goto K, Masaki T. Pressor response toendothelin in guinea pigs. Jap J Pharmacol 1989; 49: 549–552.
Goto K, Kasuya Y, Matsuki N, Takuwa Y, Kurihara H, Ishikawa T, Kimura S, Yanagisawa M,
Masaki T. Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel invascular smooth muscle. Proc Natl Acad Sci USA 1989; 86: 3915–3918.
Miyauchi T, Ishikawa T, Tomobe Y, Yanagisawa M, Kimura S, Sugishita Y, Ito I, Goto K, Masaki
T. Characteristics of pressor response to endothelin in spontaneously hypertensive and WistarKyoto rats. Hypertension 1989; 14: 427–434.
Kasuya Y, Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Mechanism of contraction to
endothelin in isolated porcine coronary artery. Am J Physiol 1989; 257: H1828–H1835.
Goto K, Ishikawa T, Fujimori A, Saito A, Kimura S. Control of the cardiovascular function by
novel peptide (CGRP)-containing nerves. In: Regulatory Roles of Neuropeptides 1989; p55–69,
Excepta Medica.
Ishikawa T, Okamura N, Saito A, Masaki T, Goto K. Positive inotropic effect of calcitonin gene–
related peptide mediated by cyclic AMP in guinea pig heart. Circ Res 1988; 63: 726–734.
Miyauchi T, Sano Y, Hiroshima O, Yuzuriha T, Sugishita Y, Ishikawa T, Saito A, Goto K. Positive
inotropic effects and receptors of calcitonin gene-related peptide (CGRP) in porcine ventricular
muscles. Biochem Biophys Res Commun 1988; 155: 289–294.
Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K. Effects of piperine on calcitonin generelated peptide (CGRP)-containing nerves in the isolated rat atria. Neurosci Lett 1988; 91: 222–
227.
Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive inotropic action of novel
vasoconstrictor peptide endothelin on guinea pig atria. Am J Physiol 1988; 255: H970–H973.
Yanagisawa M, Inoue A, Ishikawa T, Kasuya Y, Kimura S, Kumagaye S, Nakajima K, Watanabe
TX, Sakakibara S, Goto K, Masaki T. Primary structure, synthesis, and biological activity of rat
endothelin, an endothelium-derived vasoconstrictor peptide. Proc Natl Acad Sci USA 1988; 85:6964–6967.
Ishikawa T, Yanagisawa M, Kimura S, Goto K, Masaki T. Positive chronotropic effects ofendothelin, a novel endothelium-derived vasoconstrictor peptide. Pflügers Arch 1988; 413: 108–
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Goto K, Ishikawa T, Kimura S, Saito A. Intramural nerve-mediated inotropic responses of left
atria of rats and guinea pigs: demonstration of alpha adrenergic and nonadrenergic noncholinergic
responses in guinea pigs. J Pharmacol Exp Ther 1987; 243: 723–730.
Saito A, Ishikawa T, Kimura S, Goto K. Role of calcitonin gene-related peptide as cardiotonic
neurotransmitter in guinea pig left atria. J Pharmacol Exp Ther 1987; 243: 731–736.
8106) Ishikawa T, Okamura N, Saito A, Goto K. Effects of calcitonin gene-related peptide (CGRP) andisoproterenol on the contractility and adenylate cyclase activity in the rat heart. J Mol Cell
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107) Shoji T, Ishihara H, Ishikawa T, Saito A, Goto K. Vasodilating effects of human and rat calcitonin
gene-related peptides in isolated porcine coronary arteries. Naunyn-Shmiedeverg's Arch
Pharmacol 1987; 336: 438–444.
108) Miyauchi T, Ishikawa T, Sugishita Y, Saito A, Goto K. Effects of capsaicin on nonadrenergic
noncholinergic nerves in the guinea pig atria: role of calcitonin gene-related peptide as cardiac
neurotransmitter. J Cardiovasc Pharmacol 1987; 10: 675–682.
109) Saito A, Ishikawa T, Masaki T, Kimura S, Goto K. Pharmacological analysis of autonomic
innervation of the right atria of rats and guinea pigs: demonstration of nonadrenergic
noncholinergic nerves. J Pharmacol Exp Ther 1986; 238: 713–719.
and other 27 reviews and book chapters in Japanese.

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