Curriculum Vitae
March 1, 2023
Miyuki YAMAGUCHI
Current Address
52-1 Yada, Suruga-ku, Shizuoka-shi, Shizuoka 422-8526, Japane-mail: yamaguchim (at) u-shizuoka-ken.ac.jp
Position
Research Assistant Professor, Laboratory of Organic Chemistry,
School of Pharmaceutical Sciences, University of Shizuoka
Education
3/2008 Ph. D., Graduate School of Science, Tokyo University of Science
3/2005 M. S., Graduate School of Science, Tokyo University of Science
3/2003 B. S., Faculty of Science, Tokyo University of Science
Research Positions
6/2012-present Research Assistant Professor, School of Pharmaceutical Sciences, University ofShizuoka
3/2011-5/2012 Project Assistant Professor, Graduate School of Science, University of Tokyo
9/2008-3/2011 Project Researcher, Graduate School of Science, University of Tokyo
4/2008-8/2008 Researcher, The HFRE division, ERATO, JSTSociety Membership
The Chemical Society of JapanThe Pharmaceutical Society of JapanThe Society of Synthetic Organic Chemistry, Japan
Research Interests
Development of new catalytic reactions
Fellowships and Grants
4/2021-3/2024 JSPS Grant-in-aid for Scientific Research (C)4/2020-3/2021 Research Grant from the Research Foundation for Pharmaceutical Sciences
8/2018-7/2019 Research Grant from Hamamatsu Foundation for Science and Technology Promotion
4/2017-3/2020 JSPS Grant-in-aid for Scientific Research (C)4/2015-3/2017 JSPS Grant-in-aid for Young Scientist (B)4/2015-3/2016 Research Grant from the Uehara Memorial Foundation
4/2014-3/2016 Research Grant from Asahi Kasei Pharma
4/2012-3/2014 JSPS Grant-in-aid for Young Scientist (B)
4/2006-3/2008 Hayashi Fellow (Predoctral) of Hayashi Memorial Foundation for Female NaturalScientists
Awards7/2018 Young Investigator Award in Tokai Area, Synthetic Organic Chemistry, Japan
2/2014 Asahi Kasei Pharma Award in Synthetic Organic Chemistry, Japan
Publications(1) Yamaguchi, M.; Fujiwara, S.; Mori, Y.; Konishi, H.; Manabe, K.
Synthesis of Multisubstituted Pyrroles by Ligand-Controlled Site-Selective Arylation and Their
Transformation into Multiarylated Pyrrolines and Pyrrolidines.
Tetrahedron, 2022, 123, 132962.
(2) Konishi, H.; Fujita, R.; Yamaguchi, M.; Manabe, K.
Synthesis of Symmetrical Sulfides Enabled by a Sulfur Dioxide Surrogate Acting as a Divalent
Sulfur Source.
Org. Lett., 2022, 24, 3663-3667.
(3) Yamaguchi, M.; Manabe, K.
Synthesis of Multisubstituted Benzofurans/Indoles Using Multichlorinated Phenols/Anilines via
Palladium-Catalyzed Site-Selective Sonogashira Coupling.
Heterocycles, 2022, 104, 3-26.
(4) Konishi, H.; Kumon, M.; Yamaguchi, M.; Manabe, K.
Palladium-Catalyzed External-CO-Free Reductive Carbonylation of Aryl Sulfonates.
Tetrahedron, 2020, 76, 131639.
(5) Yamaguchi, M.; Hagiwara, R.; Gayama, K.; Suzuki, K.; Sato, Y.; Konishi, H.; Manabe, K.
Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides, Triflates, andNonaflates Using Palladium-Dihydroxyterphenylphosphine Catalyst.
J. Org. Chem., 2020, 58, 10902-10912.
(6) Yamaguchi, M.; Ogihara, K.; Konishi, H.; Manabe, K. Synthesis of 2,3-Disubstituted Indoles from
Alkynylanilines and 2-Chlorophenols Using Palladium‒Dihydroxyterphenylphosphine Catalyst.
Tetrahedron Lett., 2020, 61, 151896.
(7) Yamaguchi, M.; Fujiwara, S.; Manabe, K.
Synthesis of 2,2,5-Trisubstituted 2H-Pyrroles and 2,3,5-Trisubstituted 1H-Pyrroles by LigandControlled Site-Selective Dearomative C2-Arylation and Direct C3-Arylation
Org. Lett., 2019, 21, 6972-6977.
(8) Yamaguchi, M.; Ozawa, H.; Katsumata, H.; Akiyama, T.; Manabe, K.

One-Pot Synthesis of 2,3-Disubstituted Benzofurans from 2-Chlorophenols Using Palladium–
Dihydroxyterphenylphosphine Catalyst.
Tetrahedron Lett., 2018, 59, 3175-3178.
(9) Yamaguchi, M.; Suzuki, K.; Sato, Y.; Manabe, K.
Palladium-Catalyzed Direct C3-Selective Arylation of N-Unsubstituted Indoles with Aryl Chlorides
and Triflates.
Org. Lett., 2017, 19, 5388-5391.
(10)

Yamaguchi, M.; Manabe, K.

Three-Step Synthesis of 2,5,7-Trisubstituted Indoles from N-Acetyl-2,4,6-trichloroaniline UsingPd-Catalyzed Site-Selective Cross-Coupling.
Org. Biomol. Chem., 2017, 15, 6645-6655.
(11)

Yamaguchi, M.; Akiyama, T.; Sasou, H.; Katsumata, H.; Manabe, K.

One-Pot

Synthesisof

Substituted

Benzo[b]furans

andIndoles

from

Dichlorophenols/Dichloroanilines Using a Palladium-Dihydroxyterphenylphosphine Catalyst.
J. Org. Chem., 2016, 81, 5450-5463.
(12)

Yamaguchi, M.; Higuchi, M.; Tazawa, K.; Manabe:, K.

Three-Step Synthesis of Fluoranthenes through Pd-Catalyzed Inter and Intramolecular C-H
Arylation.
J. Org. Chem., 2016, 81, 3967-3974.
(13)

Yamaguchi, M.; Manabe, K.

Ligand-Controlled Site-Selective Cross-Coupling.
Site-Selective Catalysis (Kawabata, T. Ed.): Springer International Publishing: Switzerland, 2016,
pp1-25(14)

Yamaguchi, M.; Suzuki, K.; Manabe, K. Scalable Synthesis of Dihydroxyterphenylphosphine

Ligands.
Tetrahedron, 2015, 71, 2743-2747.
(15)

Konishi, H.; Muto, T.; Ueda, T.; Yamada, Y.; Yamaguchi, M.; Manabe, K.

Imidazole Derivatives as Accelerators for Ruthenium-Catalyzed Hydroesterification andHydrocarbamoylation of Alkenes: Extensive Ligand Screening and Mechanistic Study.
ChemCatChem, 2015, 7, 836-845.
(16)

Manabe, K.; Yamaguchi, M.

Catalyst-Controlled Site-Selectivity Switching in Pd-Catalyzed Cross-Coupling of Dihaloarenes.
Catalysts, 2014, 4, 307-320.
(17)

Yamaguchi, M.; Manabe, K.

One-pot Synthesis of 2,4-Disubstituted Indoles from N-Tosyl-2,3-dichloroaniline Using PalladiumDihydroxyterphenylphosphine Catalyst.
Org. Lett, 2014, 16, 2386-2389.
(18)

Yamaguchi, M.; Kimura, T.; Shinohara, N.; Manabe, K.

Repetitive Two-Step Method for o,o,p- and o,p-Oligophenylene Synthesis through Pd-Catalyzed
Cross-Coupling of Hydroxyterphenylboronic AcidMolecules 2013, 18, 15207-15219.
(19)

Yamaguchi, M.; Katsumata, H.; Manabe, K.

One-Pot Synthesis of Substituted Benzo[b]furans from Mono- and Dichlorophenols Using
Palladium Catalysts Bearing Dihydroxyterphenylphosphine
J. Org. Chem. 2013, 78, 9270−9281.
(20)

Kobayashi, S.; Kiyohara, H.; Yamaguchi, M.

Catalytic Silicon Mediated Carbon-Carbon Bond-Forming Reactions of Unactivated Amides.
J. Am. Chem. Soc, 2011, 133, 708-711.
(21)

Yamaguchi, M.; Morita, N.; Schneider, U.; Kobayashi, S.

Catalytic Use of a Soluble Organoindium(III) Species for Allylation and Crotylation of Ketones withBoronates.
Adv. Synth. Catal. 2010, 352, 1461-1465.
(22)

Chakrabarti, A.; Konishi, H.; Yamaguchi, M.; Schneider, U.; Kobayashi, S.

Indium(I)-Catalyzed Asymmetric Allylation, Crotylation, and alpha-Chloroallylation of Hydrazones
with Rare Constitutional and High Configurational Selectivities.
Angew. Chem. Int. Ed. 2010, 49, 1838-1841.
(23)

Kobayashi, S.; Yamaguchi, M.; Agostinho, M.; Schneider, U.

Catalytic Use of Strontium Hexamethyldisilazide in the Asymmetric Michael Addition of Malonate
to Chalcone Derivatives.
Chem. Lett. 2009, 38, 296-297.
(24)

Yamaguchi, M.; Ueki, M.

Study on Interactions of Oligo(tyrosine sulfate)s with Synthetic Heparin-Binding Peptides by
Affinity Chromatography and MALDI-TOF-MS.
Adv. Exp. Med. Biol. 2009, 611, 529-530.
(25)

Ueki, M.; Yamaguchi, M.

Analysis of Sulfo- and Phospho-Peptides as Tetrabutylammonium Salts by Matrix-Assisted Laser
Desorption/Ionization Time-of-Flight Mass Spectrometry.
Res. Commun. Biochem. Cell Mol. Biol. 2008, 12, 37-49.
(26)

Yamaguchi, M.; Ohmori, T.; Sakata, Y.; Ueki, M.

Oligo(tyrosine sulfate)s as Heparin Pentasaccharide Mimic: Evaluation by Surface NoncovalentAffinity Mass Spectrometry.
Bioorg. Med. Chem. 2008, 16, 3342-3351.
(27)

Yamaguchi, M.; Kikuchi, F.; Ueki, M.

Direct Detection and Comparison of Non-Covalent Complex Formation of Oligo(tyrosine sulfate)swith Synthetic Heparin-Binding Peptides by MALDI–TOF–MS.
Peptide Science 2007, Proceedings of the 44th Japanese Peptide Symposium (S. Aimoto ed.),2008, pp213-216.
(28)

Ueki, M.; Yamaguchi, M.

A Study on Interactions of Oligo(tyrosine sulfate)s with a Heparin-Binding Peptide by MALDI-TOFMS.
Peptide Science 2006, Proceedings of the 43rd Japanese Peptide Symposium/4th Peptide
Engineering Meeting (H. Ishida and H. Mihara eds.), 2006, pp188-189.
(29)

Ueki, M.; Yamaguchi, M.

Enhanced

Detectionof

Sulfo-peptides

asOnium

SaltsinMatrix-Assisted

Laser

Desorption/Ionization Time-of-Flight Mass Spectrometry.
Rapid Commun. Mass Spectrom. 2006, 20, 1615-1620.
(30)

Ueki, M.; Yamaguchi, M.

Detection of Sulfated Peptides as Their Onium Salts in the Positive Mode by MALDI-TOF Mass
Spectrometry.
Peptide Science 2005, Proceedings of the 42nd Japanese Peptide Symposium (T. Wakamiya ed.),2006, pp177-180.
(31)

Ueki, M.; Yamaguchi, M.

Analysis of Acidic Carbohydrates as Their Quaternary Ammonium or Phosphonium Salts by
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry.
Carbohydr. Res. 2005, 340, 1722-1731.
(32)

Ueki, M.; Yamaguchi, M.; Fujiwara, S.

Analysis of Sulfo- and Phospho-Peptides as Quaternary Ammonium Salts by MALDI-TOF MS.
Peptide Science 2004, Proceedings of the 1st Asian Pacific Ocean International Peptide
Symposium/41st Japanese Peptide Symposium (Y. Shimohigashi ed.), 2005, pp.187-190.
(33)

Ueki, M.; Takekawa, A.; Yamaguchi, M.

Solid Phase Synthesis, Characterization, and Physical Properties of Oligo(tyrosine sulfate)s.
Peptide Science 2003, Proceedings of the 40th Japanese Peptide Symposium (M. Ueki ed.), 2004,
pp.151-154.