FOR IMMEDIATE RELEASE: 2022/9/30

Full launch of M3 Cancer Prevention Program for Corporations～3rd phase of the White Jack Project:
Accelerating measures to combat a national disease affecting 1 out of 2 people～

M3, Inc. (Headquarters: Tokyo, Japan; CEO: Itaru Tanimura; URL: https://corporate.m3.com/; “M3”below) has announced that the M3 Cancer Prevention Program for companies will be fully launchedin October 2022 as the third phase of the White Jack Project, an initiative aimed at maintaining good
health from the pre-onset stage of disease.
1. Background of the need for the M3 Cancer Prevention Program
According to statistics, one in two Japanese will develop cancer during their lifetime*1 and one in threewill die from cancer*2. 1 in 2 people will develop cancer, which means, for example, that the probability
that someone in a family of four will develop cancer is about 93%, meaning that most people will experience
cancer in themselves or a family member. Although many people are faced with this disease, there are acertain number of patients and their families who take actions they should not take toward treatment dueto a lack of awareness of basic knowledge about cancer, and we believe that "cancer prevention" is anarea where efforts should be accelerated to raise awareness before the disease strikes.
In light of this situation, M3 is now offering the "M3 Cancer Prevention Program" to proactively support
company-based efforts regarding cancer control.
We will actively develop and deploy the program with the aim of increasing the number of "Advanced
Cancer Control Companies" to protect the health of as many employees and their families as possible,and thereby improve the cost of medical care.
2. Contents of the M3 Cancer Prevention program
The M3 Cancer Prevention Program for companies consists mainly of the following contents. As cancer
treatments are updated annually, the content will be updated accordingly.
1Providing programs to improve basic knowledge about cancer
The program will provide training on diseases and treatments, such as "What is cancer," "Standard
treatment is the most effective," and "Don't be fooled by alternative medicine that has not been provento be useful," to build a foundation of knowledge that will prevent panic when an emergency occurs.
The program is based on an educational program that was evaluated as "satisfactory by 88% ofemployees" at a company that already implemented the program.

2Improve cancer screening uptake rate
Despite the fact that early detection of cancer has a significant impact on survival rates, the cancer
screening rate at many companies has not reached the national target of 50%*3. We will reduce thenumber of employees who have not been screened for cancer by developing cancer education andmore proactive recommendations. We also plan to develop a network of medical institutions that will
work together to address the issue of "difficulty in getting an appointment even if you want to have acheckup," thereby realizing smooth access to checkups.

3

Establishment of a primary contact point for cancer cases
A primary consultation service will be set up for medical professionals to respond to patients when theyor their family members are affected by cancer. This is similar to a non-life insurance company'saccident response desk. Experts with a wealth of knowledge about cancer will accompany the patientwith advice on tests, diagnosis, treatment, hospital selection, and other matters, providing extensive
support for the initial response of patients who are often shocked and panic-stricken.

4Providing second opinions from multiple specialists
Only about one in five*4 people who have cancer obtain a second opinion, and even when they do, inmost cases it is "from one doctor after one month.” The M3 Cancer Prevention Program utilizes M3's

network of physicians to obtain second opinions (multi-opinions) from three specialists within two tothree weeks. The program targets not only employees, but also their families and parents, and helps
them make better treatment choices based on the opinions of multiple specialists. In the previous
implementation of this system, the NPS of users was 78, which is a very high level of satisfaction.
5

Support for affected persons in their daily lives and return to work
Once treatment for cancer begins, balancing work and treatment in addition to providing support indaily life becomes important. In the M3 Cancer Prevention Program, experts provide advice to cancer
survivors on their daily lives and help them return to the workplace after treatment, in cooperation withthe human resources department of the company where the program is implemented. The program
also prevents "surprise resignation," in which a cancer survivor abruptly resigns without consulting thecompany, aiming to realize a better life for cancer survivors.

Dr. Shotaro Oshikawa, a physician who advocates cancer disaster prevention, commented on thedevelopment of this program.
“Cancer prevention" is the concept of minimizing damage and rebuilding one's life by preparing in
advance so that one can continue to live a better life even if one has cancer. It is very important to havethe right knowledge and be prepared before you get cancer so that you do not panic or make the wrong
choices in a panic when the time comes. It is meaningful that the concept of cancer disaster prevention
and efforts like this are spreading to companies, and I look forward to the expansion of these activities.”
Through this initiative, M3 will expand the number of "advanced cancer prevention companies" that areprepared for cancer, protect the health of as many employees and their families as possible, and thereby
reduce medical costs. In fact, according to a survey conducted by the National Federation of Health
Insurance Societies, which is comprised of corporate health insurers, cancer (tumors) accounts for 19%
of medical expenses (hospitalization,) the largest percentage of all medical expenses, and byimplementing cancer prevention, we aim to improve the current situation of increasing medical expenses.
■Image of the “White Jack Project”※1 National Cancer Center Japan Cancer Control Information Center※2 Ministry of Health, Labour and Welfare Demographic Statistics※3 Target 50% cancer screening uptake rate and 90% uptake rate for full examinations in the Basic Plan forthe Promotion of Cancer Control※4 National Cancer Center Japan From 2020 Patient Experience JourneyDr. Shotaro Oshikawa profile
Gastroenterology and Oncology Physician. Specializes in anticancer treatment and palliative therapy.
Graduated from the School of Medicine, University of Miyazaki in 1995. After serving as a resident in theDepartment of Gastrointestinal Endoscopy at the National Cancer Center East Hospital, established theDepartment of Gastrointestinal Cancer Anticancer Therapy at the First Department of Internal Medicine,Miyazaki University Hospital in 2002. Established the NPO Miyazaki Cancer Kyodo Study Group in 2009. Livecancer counseling drinking sessions where you can ask any questions every Sunday night on the YouTube
Cancer Prevention Channel.