৾୒တཫೖਭೖ૛ધ੦ຊधಏ෫‫঺؞‬ভ৾भ૏্ऋীऊॊ৬৔ৎੑଢ଼஢঻॑৯੐खथিਉ ર叞ଫഏিপ৾ ৶ੵ৾୒੹‫ق‬ਠ ઁਣপ৾প৾੹ ୢ௺ఐ৾ଢ଼஢ఐ ਁಃୋে৾ઇ஼‫ك‬ ࡣࡌࡵ࡟࡜࡚ࡶ⥡㯇࡟ฟࡉࢀ࡚࠸ࡲࡋࡓࠋࡑࡢࢹ࣮ࢱ࡟ឤ㖭ࢆཷ⚾࡟࡜ࡗ࡚࣓࢖ࣥࡢᏛ఍࡛࠶ࡿ᪥ᮏ᫬㛫⏕≀Ꮫ఍࡟ࡅࡓࡢࢆ௒࡛ࡶぬ࠼࡚࠸ࡲࡍࠋࡑࡢ㡭࠿ࡽ⚾ࡣࠊయෆ᫬࠾࠸࡚ࠊዡບ㈹ࢆཷ㈹࡛ࡁࡓࡇ࡜ࢆ㠀ᖖ࡟Ꮀࡋࡃᛮ࠸ࡲィࡢྠㄪࠊ᫬้ྜࢃࡏࡢ࣓࢝ࢽࢬ࣒ࡸᛂ⏝᪉ἲࡢ◊✲ࢆࡍࠋᑂᰝ࡟㛵ࢃࡗࡓከࡃࡢඛ⏕᪉࡟ឤㅰ⮴ࡋࡲࡍࠋࡲࡓࠊࡍࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠋ㣗஦ࡸᶵ⬟ᛶ㣗ရᡂศ࡟ࡼࡿྠ⚾ࡢᜠᖌ࡛࠶ࡿᰘ⏣㔜ಙᩍᤵࡢ◊✲ᐊ༞ᴗ⏕࡜ࡋ࡚ࠊึㄪస⏝ࡶࡑ࠺࡛ࡍࡀࠊ≀⌮ⓗ࣭ᚰ⌮ⓗ࡞ࢫࢺࣞࢫ㈇Ⲵࠊ

ࡵ࡚ࡢཷ㈹࡟࡞ࡗࡓࡇ࡜ࡶ኱ኚᎰࡋ࠸㝈ࡾ࡛ࡍࠋ୍⥴࡟㐠ືࠊ ᗘ࡜࠸ࡗࡓ⎔ቃᅉᏊ࡟ࡼࡿᴫ᪥᫬ィࡢ᫬้ㄪ⠇◊✲ࢆ⾜ࡗ࡚᮶ࡓᰘ⏣◊ࡢⓙᵝࠊඹྠ◊✲⪅ࡢⓙᵝ࡟ࡶࠊࡢ◊✲ࡶ⾜࠸ࡲࡋࡓ 2ࠋ᫬㛫ᰤ㣴Ꮫ◊✲ࡣࡑࡢᚋࠊࡇࢀࡇࡢሙࢆ࠾೉ࡾࡋ࡚ឤㅰ⏦ࡋୖࡆࡲࡍࠋඛ᪥Ἀ⦖࡛⾜ࢃࡲ࡛ࡢᰤ㣴Ꮫ࡟Ḟࡅ࡚࠸ࡓࠕ࠸ࡘ㸽ࠖ࡜࠸࠺᪂ࡓ࡞࢔࢖

ࢀࡓཷ㈹⪅ㅮ₇ࡢෆᐜ࡟ྜࢃࡏ࡚ࠊᮏᩥࢆᇳ➹⮴ࡋࡲࡋ

ࢹ࢔ࢆ㈇Ⲵࡋࡓ᪂ࡓ࡞Ꮫၥ࡜ࡋ࡚ㄆ▱ࡉࢀࠊ᪥ᮏ᫬㛫ᰤࡓࠋᣋ࠸ᩥ❶࡛ࡍࡀࠊࡈ஢ᢎୗࡉ࠸ࠋ㣴Ꮫ఍ࡀ࡛ࡁࠊ㞧ㄅ࡛ከࡃྲྀࡾୖࡆࡽࢀࡿ࡞࡝ヰ㢟࡟࡞ࡾࡲࡋࡓ 3ࠋᰘ⏣◊࡟࠸࡚ࡇࡢࡼ࠺࡞᪂ࡓ࡞◊✲ศ㔝ࡢ ᫬㛫ᰤ㣴Ꮫࡢ☜❧࡟ᦠࢃࡿ⚾ࡣࡇࢀࡲ࡛ࠊ᫬㛫⏕≀Ꮫࡢᛂ⏝ࢆ┠ᣦࡋࡓᇶ♏◊✲❧ࡕୖࡆ࡟㛵ࢃࡿࡇ࡜ࡀ࡛ࡁࠊ◊✲⪅࡜ࡋ࡚࡜࡚ࡶ㈗㔜
࡞⤒㦂ࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ

ࢆ⾜ࡗ࡚ࡁࡲࡋࡓࠋ2008 ᖺࡢᰘ⏣◊✲ᐊ㓄ᒓᙜึࡣࠊ㣗஦࡟ࡼࡿᴫ᪥᫬ィࡢྠㄪ࣓࢝ࢽࢬ࣒࡟ࡘ࠸࡚◊✲ࡋ ࢔࢘ࢺ࣮ࣜࢳάືࡢ㞴ࡋࡉ࡚࠸ࡲࡋࡓࠋᰘ⏣◊࡛ࡣᙜ᫬ࠊ㣵ࡢ⤌ᡂ㸦⢾㉁ࡸ⬡㉁࡞

ࢫ ࢺ ࣞ ࢫ ㈇ Ⲵ ࡢ ◊ ✲ ࡛ ࡣ ࠊ in vivo whole body࡝㸧ࡸᶵ⬟ᛶ㣗ရᡂศࢆኚ࠼ࡓ㣵ࢆ୚࠼࡚ࠊ࣐࢘ࢫࡢᮎ

imaging ࢆ⏝࠸ࡓ࣐࢘ࢫᮎᲈ᫬ィ఩┦ホ౯⣔ࢆ⏝࠸ࠊಶᲈ᫬ィྠㄪࢆぢࡿᐇ㦂ࡀ⾜ࢃࢀ࡚࠸ࡲࡋࡓࠋ⚾ࡣࠊ㣗஦య࡛ࣞ࣋ࣝࠊᣊ᮰ࢫࢺࣞࢫࡸ♫఍ⓗᩋ໭ࢫࢺࣞࢫࡢᮎᲈࡢ⤌ᡂࡼࡾࡶࠊ㣗஦ࡑࡢࡶࡢ࡟ࡼࡿᮎᲈ᫬ィࡢྠㄪ࣓࢝᫬ィ࡬ࡢᙳ㡪ࢆㄪ࡭ࡲࡋࡓ 4ࠋ఩┦ᛂ⟅᭤⥺ࢆ᭩ࡃࡓࡵࢽࢬ࣒ࡀศ࠿ࡗ࡚࠸࡞࠸࠿ࡽࠊࡲࡎࡣࡇࡇ࠿ࡽゎỴࡍ࡭࡟ࠊ◊✲ᐊࡢᚋ㍮࡜ఱᗘࡶ◊✲ᐊ࡟Ἡࡲࡾࡲࡋࡓࠋ◊✲ࡁ࡛ࡣ࡜ᛮ࠸◊✲ࢆጞࡵࡲࡋࡓࠋࡑࡇ࡛ࠊ⤯㣗Ɇ෌⤥㣵ᐊࡢⓙࡉࢇࡢຓࡅࡀ࡞ࡅࢀࡤฟ᮶࡞࠿ࡗࡓ◊✲ࡔ࡜ᛮᚋࡢ᫬ィ㑇ఏᏊࡢኚືࢆ⫢⮚࡛ㄪ࡭ࠊ㣗ᚋ࡟ Per2 ࡸ࠸ࡲࡍࠋࡲࡓࠊㄽᩥᥖ㍕᫬࡟ࣉࣞࢫ࣮ࣜࣜࢫࡋࡓ⤖ᯝࠊ

Rev-HUEǂ ࡀⓎ⌧ኚ໬ࢆ㉳ࡇࡍࡇ࡜ࡀࠊ᫬ィ఩┦ኚ໬ࡢࡕࡻ࠺࡝ᚑᴗဨࡢࢫࢺࣞࢫࢳ࢙ࢵࢡࡀ⩏ົ໬ࡉࢀࡓ᫬ึື࡛࠶ࡿࡇ࡜ࢆᥗࡳࡲࡋࡓࠋࡑࡢᚋࠊ㐣ཤࡢᩥ⊩࠿ࡽ࡛࠶ࡗࡓࡓࡵࠊNHK ࡢྲྀᮦࢆཷࡅࡿᶵ఍ࡀ࠶ࡾࡲࡋࡓࠋ

࢖ࣥࢫࣜࣥ࡟╔┠ࡋࠊPer2 ࡢⓎ⌧ୖ᪼࡟࢖ࣥࢫࣜࣥࡀࡑࡢ㝿ࠊࢫࢺࣞࢫᛂ⟅ࡢ᪥ෆࣜࢬ࣒ࡢࢹ࣮ࢱ࠿ࡽࠊࠕኤ┤᥋㛵ࢃࡗ࡚࠸ࡿࡇ࡜ࢆ♧ࡋࡲࡋࡓ 1ࠋࡑࡢᚋࠊ௚◊✲᪉࠿ࡽኪࡢࢫࢺࣞࢫ㈇Ⲵࡣయෆ᫬ィࡢኪᆺ໬ࢆᣍࡁⰋᐊ࠿ࡽࡶ࢖ࣥࢫࣜࣥ࡟ࡼࡿᮎᲈ᫬ィྠㄪ࡟ࡘ࠸࡚ㄽᩥࡃ࡞࠸ࡢ࡛ࡣࠖࠊ࡜࠸ࡗࡓ⤖ㄽࢆ♫఍࡟ྥࡅ࡚Ⓨಙࡋࡲࡀ┦ḟࡂࠊ௒࡜࡞ࡗ࡚ࡣ㣗ᚋࡢ᫬ィྠㄪ࡟࠾࠸࡚ࠊ࢖ࣥ

ࡋࡓࠋࡋ࠿ࡋࠊNHK ࡢグ⪅ࡉࢇ࠿ࡽࡣࠊࠕୖྖࡣ㒊ୗ࡟ࢫࣜࣥࡣ࣓࢖ࣥࣉࣞ࢖࣮ࣖ࡜ࡋ࡚ㄆ㆑ࡉࢀࡿ࡟⮳ࡗ࡚ᮅ࡟ྏࡾࠊኤ᪉ࡣඃࡋࡃᖐࡋ࡚࠶ࡆࡿ࡭ࡁࠖࠊ࡜࠸ࡗࡓ࠸ࡲࡍࠋᐇ㦂ࡢ㝿ࠊ࢖ࣥࢫࣜࣥࡢ⣽⬊࡬ࡢ┤᥋ⓗ࡞ຠᯝ࠿࡞ࡾ◊✲⤖ᯝ࠿ࡽ㣕㌍ࡋࡓࢥ࣓ࣥࢺࢆゝ࠺ࡼ࠺࡟ồࢆ☜࠿ࡵࡿ࡭ࡃࠊᮾ኱῝⏣◊✲ᐊࡢྜྷ✀ගඛ⏕㸦⌧㸸ᮾࡵࡽࢀࠊࡑࡢࡼ࠺࡟࣓࢝ࣛࡢ๓࡛⚾ࡀⓎゝࡋࠊࡑࡢෆᐜி㒔་Ꮫ⥲ྜ◊✲ᡤ㸧࡟ࠊPER2::LUC ࣐࢘ࢫࡢ⫾ඣ⏤ࡀࡲࡉ࡟ኪࡢ NHK ࢽ࣮ࣗࢫ࡛ఱᗘࡶὶࢀࡿ࡜࠸࠺஦᮶⥺⥔ⱆ⣽⬊ࡢసࡾ᪉ࢆᩍ࠼࡚㡬ࡁࡲࡋࡓࠋᙜ᫬ࠊྜྷ✀ែࡀ㉳ࡁ࡚ࡋࡲ࠸ࡲࡋࡓࠋࠕᇶ♏◊✲ࢆ࠸࠿࡟♫఍࡟ศඛ⏕ࡀࠊⓎගࣜࢬ࣒ࢆィࡋ࡞ࡀࡽࠊ⣽⬊࡟఩┦ྠㄪ่࠿ࡾࡸࡍࡃఏ࠼ࡿ࠿ࠖࠊ࠸ࡘࡶᝎࡲࡋ࠸ၥ㢟࡛࠶ࡾࡲࡍ⃭ࢆ୚࠼ࠊࡑࡢᚋࡢ఩┦ࢩࣇࢺࢆほᐹࡋ఩┦ᛂ⟅᭤⥺ࢆࡀࠊࡇࡢヰࡣ࠶ࡲࡾ࡟ࡶ⮬ศࡢ◊✲⤖ᯝ࡜࠿ࡅ㞳ࢀ࡚࠸‫ ݩ‬yutahara0829@gmail.com᫬㛫⏕≀Ꮫ9RO1R 

ᰘ⏣◊ࡢ㞟ྜ෗┿ࠋ➨ 28 ᅇ᪥ᮏ᫬㛫⏕≀Ꮫ఍Ꮫ⾡኱఍ࠊἈ⦖࡟࡚ࠋ➹⪅ࡣ๓ิᕥ࠿ࡽ 3 ␒┠ࠋ㸦ᒾᓮ⚽㞝ඛ⏕࡟᧜ࡗ࡚㡬࠸ࡓࡢ࡛ࡍࡀࠊ࡞ࢇ࡜ᕥྑ࡟࠶࡜஧ேぢษࢀ࡚࠾ࡾࡲࡋࡓࠊࠊ
ࠊ㸧ࡓࡓࡵࠊ࣓࢝ࣛࡢ๓ࡢⓎゝࢆ࡜࡚ࡶ᜼ࡸࡳࡲࡋࡓࠋ୍᪉ࡓࠋ⡿ᅜ࡟࠾ࡅࡿ◊✲㈝ࡢࣛ࣎㛫ࡢ㈋ᐩࡢᕪࡣ࡜࡚ࡶ኱

࡛ࠊࡑࡢ㡭࠿ࡽᑡࡋࡎࡘ࡛ࡍࡀࠊᰘ⏣◊࡛┠ᣦࡍࠕᛂ⏝ࡁ࠿ࡗࡓ࡛ࡍࠋRO1㸦⛉◊㈝࡛࠸࠺ᇶ┙◊✲㸧ࡸ R21◊✲ࢆぢᤣ࠼ࡓᇶ♏◊✲ࠖࡢ⌮᝿ീࡀぢ࠼࡚ࡁࡓࡼ࠺࡟

㸦ⴌⱆ◊✲㸧ࡢ᥇ᢥ⋡ࡀ 10%ࢆษࡗ࡚࠾ࡾࠊࡉࡽ࡟ᑂ

ឤࡌࡲࡍࠋᰝࡶ࡜࡚ࡶཝࡋࡃࠊ୍ᗘྲྀࢀ࡞ࡃ࡞ࡿ࡜㏺࠸ୖࡀࡿࡇ࡜ࡀ㞴ࡋ࠸ࡢࡀ⌧≧࡛ࡋࡓࠋColwell ࡛ࣛ࣎ࡢ⚾ࡢ௙஦ࡣࠊ ␃Ꮫ࡛ᚓࡓࡇ࡜᫬㛫ᰤ㣴Ꮫࢆ⚄⤒ኚᛶ⑌ᝈࣔࢹࣝ࡟ྲྀࡾධࢀࡿࡇ࡜࡛ࠊ

ᖾ㐠࡞ࡇ࡜࡟ࠊ༤ኈㄢ⛬ࡢ㛫࡟㸯ᖺ㛫ࠊࡉࡽ࡟ゼၥຓண㜵ຠᯝࢆぢฟࡍࡶࡢ࡛ࡋࡓࠋࡇࢀࡲ࡛ Colwell ࣛ࣎ࡣᩍ࡜ࡋ࡚ 2 ᖺ༙ࠊࢺ࣮ࢱࣝ 3 ᖺ༙ UCLA ࡢ ChristopherSCN ࡢ㟁Ẽ⏕⌮࡛ⴭྡ࡞ᴗ⦼ࢆᣲࡆ࡚࠸ࡲࡋࡓࡀࠊᇶColwell ᩍᤵࡢࡶ࡜࡛␃Ꮫࡍࡿᶵ఍ࢆᚓࡿࡇ࡜ࡀ࡛ࡁ♏◊✲࡛ࡣ◊✲㈝ࡀ⋓ᚓࡋ࡙ࡽ࠸࡜࠸࠺ࡇ࡜࡛ᛂ⏝◊ࡲࡋࡓࠋColwell ᩍᤵࡣ࡜࡚ࡶඃࡋࡃࠊ᪥ᮏዲࡁ࡛ࠊᚰ✲࡟ࢩࣇࢺࡋ࡚࠸ࡿ࡜ࡇࢁ࡛ࡋࡓࠋ⚄⤒ኚᛶ⑌ᝈ࡛ࡣ㓄஦ࡀ࠶ࡿ࡜ぶ㌟࡟ᑐᛂࡋ࡚ୗࡉࡿ࡜࡚ࡶ⣲ᬕࡽࡋ࠸

SCN ࡟࠾ࡅࡿ⚄⤒άືࡢ᪥ෆࣜࢬ࣒ࡀపୗࡋࠊ୰ᯡ᫬࣓ࣥࢱ࣮࡛ࡋࡓࠋ༤ኈㄢ⛬࡛⾜ࡗࡓ᫬ࡣࠊึࡵ࡚ࡢ␃Ꮫࠊィࡢฟຊ࡟୙ලྜࡀ⏕ࡌࠊ╧╀㞀ᐖࡀ㉳ࡇࡾࡲࡍࠋࡑࡇ࠿ࡘึࡵ࡚ࡢ୍ேᬽࡽࡋ࡛ࡋࡓࡀࠊᐙࡀỴࡲࡿࡲ࡛ࡢ㛫࡛ࠊග࡛ࡣ࡞ࡃࠊ㣗஦ࢆ౑ࡗ࡚ᮎᲈ᫬ィ࠿ࡽయෆ᫬ィࡢࡣ Colwell ඛ⏕ࡢᐙ࡟Ἡࡵ࡚㡬࠸ࡓࡾࠊࢧࣥࢡࢫࢠࣅ࣓ࣥࣜࣁࣜࢆ㧗ࡵࠊ╧╀㞀ᐖࡸ௚ࡢ⑕≧ࡢண㜵࣭ᨵၿࢆ≺ࢢࢹ࣮ࡣẖᖺ࣮࣒࣍ࣃ࣮ࢸ࢕࣮࡟࿧ࢇ࡛ୗࡉࡾࡲࡋࡓࠋ࠺࡜࠸࠺ᡓ␎࡛ࡋࡓࠋ◊✲⤖ᯝࡣ࡜࡚ࡶ࣏ࢪࢸ࢕ࣈ࡞ࡶ

UCLA Ꮫ㛗࡛࠶ࡿ Gene Block ᩍᤵ࡟ࡶ࠾ୡヰ࡟࡞ࡾࠊࡢ࡛ㄽᩥࡶฟࡓࡢ࡛ࡍࡀ 5ࠊ◊✲㈝⏦ㄳ᭩ࡢホ౯ࡣࡼࡃ㠀ᖖ࡟ᚰᙉ࠸ࢧ࣏࣮ࢺࢆ㡬ࡁࡲࡋࡓࠋࡉࡽ࡟㸰ᅇ┠ࡢ␃࠶ࡾࡲࡏࢇ࡛ࡋࡓࠋ⌮⏤ࡣࠊ⚄⤒ኚᛶ⑌ᝈ㸦≉࡟ᡃࠎࡀᏛ᫬࡟ࡣ஧ேࡢፉࡀࢧࣥࢱࣔࢽ࢝ࡢ⑓㝔࡛⏘ࡲࢀࡲࡋᶆⓗ࡟ࡋ࡚࠸ࡓࣁࣥࢳࣥࢺࣥ⑓㸧ࡢᝈ⪅ࡉࢇࡣ⑭ࡏ࡚࠾ࡓࠋࡋ࠿ࡋࠊᴦࡋ࠸␃Ꮫ࡛࠶ࡗࡓࡢࡣ☜࠿࡛ࡍࡀࠊ㸰ᅇࡾࠊ㣗஦᫬้ࢆไ㝈ࡍࡿࡼ࠺࡞἞⒪ࡣ⌧ᐇⓗ࡛ࡣ࡞࠸࡜┠ࡢ␃Ꮫࡣ◊✲࡜ࡋ࡚ࡣⱞᝎࡢ㐃⥆࡛ࡋࡓࠋࡲࡎࠊΏ⡿࠸࠺ពぢ࡛ࡋࡓࠋ⚾ࡣࡇࡇ࡛ึࡵ࡚ࠊᝈ⪅ࡉࢇ࡟ᛂ⏝࡛ᚋࡍࡄ࡟ࣛ࣎ࡢ◊✲㈝ࡀ㏵ษࢀ࡚࠸ࡿࡇ࡜ࢆ▱ࡾࡲࡋࡁ࡞࠸ࡼ࠺࡞ᇶ♏◊✲ࢆ⾜ࡗ࡚࠸ࡓࡇ࡜࡟Ẽ࡙ࡁࡲࡋ᫬㛫⏕≀Ꮫ9RO1R ࡓࠋᡓ␎࡜ࡋ࡚ࡣ࣓࢝ࢽࢬ࣒ࢆᥗࡴࡇ࡜࡛ࠊ㣗஦௨እࡢண㜵⟇ࢆᥦ᱌ࡋࡓ࠸࡜࠸࠺ὶࢀ࡟⏦ㄳ᭩ࡣኚ᭦ࡉࢀࡓ ࠾ࢃࡾ࡟ࡢ࡛ࡍࡀࠊࡑࡢᚋ࡞࠿࡞࠿◊✲㈝ࡀྲྀࢀࡎࠊ⚾ࡣᰘ⏣◊⚾ࡣࡇࢀ࠿ࡽࡶᴫ᪥᫬ィࠊ╧╀◊✲ࢆ⥅⥆ࡋࡓ࠸࡜⪃࡟ᡠࡿࡇ࡜ࢆỴࡵࡲࡋࡓࠋ୍᪉࡛⚾ࡀᖐᅜᚋ࡟ Colwell࠼࡚࠸ࡲࡍࠋಶࠎே࡟ᑐᛂࡋࡓ᫬㛫೺ᗣ⛉Ꮫࡢᥦ᱌ࢆ⪃◊✲ᐊ࡛ࡣ◊✲㈝ࡀྲྀࢀࡓࡼ࠺࡛ࡍࠋࡲࡓࠊ␃Ꮫ୰ࡣ

࠼ࡿୖ࡛ࠊࡲࡔࡲࡔᴫ᪥᫬ィࡢ࢚ࣅࢹࣥࢫࡸ࣓࢝ࢽࢬ࣒Colwell ࣛ࣎ࡢ OB ࡛࠶ࡿ୰ᮧᏕ༤ඛ⏕㸦⌧㸸᫂἞኱Ꮫ㸧ゎ᫂ࡀᚲせࡔ࡜⪃࠼ࡲࡍࠋ౛࠼ࡤ࡛ࡍࡀࠊኪ໅⪅࡬ࡢᑐ࡟࣮ࣜࣔࢺ࡛ᢏ⾡࣭◊✲㈝ඹ࡟ᨭ᥼㡬ࡁࠊ◊✲ࢆ㐍ࡵࡿᛂ⟇ࡣ᏶඲࡞ࡶࡢࡀฟ᮶࡚࠸ࡿ࡜ࡣゝ࠼ࡲࡏࢇࠋࡲࡓࠊࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋᖐᅜᚋࡣࠊ᪩✄⏣኱Ꮫࠊ᫂἞኱Ꮫࠊࢡࣟࣀࢱ࢖ࣉ࡜࠸࠺యෆ᫬ィࡢಶᛶࢆ↓どࡋࡓࡇࡢ⌧UCLAࠊࣛ࢖ࢹࣥ኱Ꮫ࡜ࡢᅜ㝿ඹྠ◊✲㈝࡟ࡶ᥇ᢥࡉࢀࠊ

௦♫఍ࢆኚ࠼࡚࠸ࡃᚲせࡀ࠶ࡾࡲࡍࠋᴫ᪥᫬ィࡢᛂ⏝◊ࡇࡢ␃Ꮫࡢᡂᯝࡀࡸࡗ࡜ᚓࡽࢀࡓ࡜ឤࡌ࡚࠸ࡿ࡜ࡇࢁ✲ࢆ࠸࠿࡟⥅⥆ࡋࠊࡲࡓ࠸࠿࡟♫఍࡟ྥࡅ࡚Ⓨಙࡋ࡚࠸࡛ࡍࠋࡃ࡭ࡁ࠿ࠊࡲࡔࡲࡔ⟅࠼ࡣぢ࠼࡚࠸ࡲࡏࢇࡀࠊ⥅⥆࡜ດຊ࠶ࡿࡢࡳ࡛ࡍࠋ௒ᅇࠊࠕᇶ♏࡜⮫ᗋ࣭♫఍Ꮫࡢ୧᪉ࡀ ࣄࢺ◊✲ࢆྲྀࡾධࢀࡓ◊✲ࢫ࣮࣒࢟ศ࠿ࡿయෆ᫬ィ◊✲⪅ࢆ┠ᣦࡋ࡚ࠖ࡜࠸࠺ࢱ࢖ࢺࣝࢆ௜ᖐᅜᚋࡢ◊✲ࡣᡭ᥈ࡾ࡛ࡋࡓࠋ␃Ꮫ࡟ᡂຌࡋࡓ࡜ࡣゝࡅࡲࡋࡓࠋ⚾ࡢࡇࢀࡲ࡛ࡢ⤒㦂ࢆ⏕࠿ࡋ࡚ࡇࡢࡼ࠺࡞⌮࠼ࡎࠊ↓୍ᩥ࡛ࣁ࢖࢖ࣥࣃࢡ࡞ᴗ⦼ࡶ↓ࡃᖐᅜࡋࡓ㌟࡛᝿ീࢆ┠ᣦࡋ࡚ࡳࡼ࠺࡜ᛮࡗ࡚࠸ࡲࡍࠋࡇࢀ࠿ࡽࡶ᪥ᮏ࠶ࡗࡓࡓࡵࠊᚲṚ࡟᪂つ◊✲ࣉࣟࢪ࢙ࢡࢺࢆ❧ࡕୖࡆࠊ᫬㛫⏕≀Ꮫ఍ࡢάᛶ໬࡟ᐤ୚࡛ࡁࡿࡼ࠺㡹ᙇࡾࡓ࠸࡜◊✲㈝ࡢ⏦ㄳ᭩ࢆ᭩ࡁࡲࡃࡾࡲࡋࡓࠋ㸯ᖺ༙࡯࡝⤒㐣ࡋࠊᛮ࠸ࡲࡍࠋࡼࢁࡋࡃ࠾㢪࠸࠸ࡓࡋࡲࡍࠋ◊✲㈝ࡶྲྀࢀࡎࡶ࠺㥏┠࠿࡜ᛮࡗ࡚࠸ࡓ㡭ࠊ◊✲㈝ࡢ᥇
ᢥ㐃⤡ࡀḟࠎ࡜᮶ࡲࡋࡓࠋᰘ⏣ඛ⏕ࡢࢫࢫ࣓ࡶ࠶ࡗ࡚ࠊཧ⪃ᩥ⊩⌧ᅾࡣࣄࢺㄪᰝ◊✲࡜ື≀ヨ㦂ࢆ⤌ࡳྜࢃࡏࡓ◊✲ࢫ

1.

Tahara, Y., Otsuka, M., Fuse, Y., Hirao, A. &ࢱ࢖ࣝࢆ☜❧ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓ 6,7ࠋࡘࡲࡾࠊࣄࢺࡢ

Shibata, S. Refeeding after fasting elicits

ࢹ࣮ࢱ࠿ࡽ㠃ⓑ࠸⌧㇟ࡸ࢔࢖ࢹ࢔ࢆぢࡘࡅࠊࡑࢀࢆື≀insulin-dependent regulation of Per2 and Rev-ヨ㦂࡟ⴠ࡜ࡋ㎸ࡴࡇ࡜࡛ᛂ⏝ࢆព㆑ࡋࡓᇶ♏◊✲ࢆᒎHUEǂ ZLWK VKLIWV LQ WKH OLYHU FORFN J BiolRhythms 26, 230-240 (2011).

㛤ࡍࡿࠊ࡜࠸࠺࠸ࢃࡺࡿࣜࣂ࣮ࢫࢺࣛࣥࢫ࣮ࣞࢩࣙࢼࣝ◊✲࡛ࡍࠋ⮫ᗋࡢඛ⏕᪉ࡣࡶࡕࢁࢇᬑẁ࠿ࡽᐇ㊶ࡉࢀ࡚

2.

Tahara, Y., Aoyama, S. & Shibata, S. The࠸ࡓࡇ࡜࠿࡜ᛮ࠸ࡲࡍࡀࠊ⌮ᕤᏛ㒊ฟ㌟ࡢ⚾࡟࡜ࡗ࡚ࡣ

mammalian circadian clock and its entrainment᪂㩭࡛ࠊࡇࢀࡲ࡛ࡢ◊✲ࡸ⤒㦂ࠊኻᩋ࠿ࡽ⮬↛࡜ᑟࡁฟby stress and exercise. J Physiol Sci 67, 1-10(2017).

ࡉࢀࡓ◊✲ࢫࢱ࢖࡛ࣝ࠶ࡾࡲࡍࠋᖾ࠸࡞ࡇ࡜࡟ࠊࠕ᪩✄⏣኱Ꮫࠖࠊࠕ᫬㛫ᰤ㣴Ꮫࡢᰘ⏣ඛ⏕ࠖ࡜࠸࠺▱ྡᗘࢆୖᡭ

3.

Tahara, Y. & Shibata, S. Circadian rhythms ofࡃά⏝ࡋࠊ኱ᡭ௻ᴗᵝ࡜ඹྠ◊✲ࡍࡿᶵ఍ࢆᚓࡿࡇ࡜ࡀ

liver physiology and disease: experimental and࡛ࡁࡲࡋࡓࠋ≉࡟ࠊ㣗஦⟶⌮࢔ࣉࣜ᭱኱ᡭࡢᰴᘧ఍♫clinical evidence. Nat Rev Gastroenterol Hepatolasken㸦࠶ࡍࡅࢇ㸧ࡉࢇ࡜ࡣࠊ฼⏝⪅ࢹ࣮ࢱࢆୖᡭࡃά

13, 217-226 (2016).

⏝ࡋࡓ኱つᶍㄪᰝ◊✲ࠊ኱つᶍ࣮ࣜࣔࢺ௓ධ◊✲ࢆᐇ㊶

4.

Tahara, Y. et al. Entrainment of the mouse୰࡛ࡍ 7ࠋࢥࣟࢼ࡜ඹ࡟᫬௦ࡣᛴ㏿࡟ኚࢃࡾࠊࢹ࣮ࢱࢆ

circadian clock by sub-acute physical andࡓࡃࡉࢇᣢࡗ࡚࠸ࡿࡇ࡜ࡀᙉࡳ࡟࡞ࡿ࡞࡜᪥ࠎឤࡌ࡚

psychological stress. Sci Rep 5, 11417 (2015).

࠸ࡿḟ➨࡛ࡍࠋ୍᪉࡛ࣄࢺࡢࣇ࢕࣮ࣝࢻࢹ࣮ࢱࡣࣀ࢖ࢬ

5.

Whittaker,D.

S.

etal.

Circadian-basedࡸಶேᕪࡀ኱ࡁࡃࠊື≀ヨ㦂࡜ࡣ␗࡞ࡿᝎࡳࡀᑾࡁࡲࡏ

Treatment Strategy Effective in the BACHDࢇࠋࡲࡓࠊ♫఍Ꮫࡸ⾜ືᚰ⌮Ꮫ࡜࠸ࡗࡓື≀ヨ㦂࡛ࡣ⪃Mouse Model of Huntington's Disease. J Biol࠼࡞ࡃ࡚ࡼ࠿ࡗࡓㄢ㢟࣭࢔࢖ࢹ࢔ࡀḟࠎ࡜ฟ࡚ࡁࡲࡍࠋ

Rhythms 33, 535-554 (2018).

ࣄࢺࡢ⌧ᐇⓗ࡞ࢹ࣮ࢱࢆ▱ࡗ࡚ࡋࡲ࠸ࠊ㏫࡟ᛂ⏝◊✲ࡢ

6.

Tahara, Y. et al. Association between Irregular㞴ࡋࡉࡀቑࡋ࡚ࡋࡲࡗࡓࡼ࠺࡟ࡶឤࡌࡲࡍࠋࡇࡢࡼ࠺࡞Meal Timing and the Mental Health of Japanese⌧≧࡛ࡍࡀࠊ2022 ᖺ 4 ᭶࠿ࡽࠊᗈᓥ኱Ꮫ་Ꮫ㒊බ⾗⾨Workers. Nutrients 13 (2021).

⏕Ꮫᩍᐊ㸦ஂಖ㐩ᙪᩍᤵ㸧࡟࡚ࠊ᪂つ࡟◊✲ࢆጞࡵࡿᶵ

Tahara, Y. et al. Changes in sleep phase and body఍ࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ⌮ᕤᏛ㒊࠿ࡽࡶࡗ࡜⮫ᗋ࡟

weight of mobile health App users during㏆࡙ࡅࡿࡼ࠺࡞⎔ቃ࡟⛣ࡿ࡜࠸࠺ࡇ࡜࡛ࠊ㠀ᖖ࡟ᴦࡋࡳ

COVID-19 mild lockdown in Japan. Int J Obes࡛ࡍࠋ

(Lond) 45, 2277-2280 (2021).

᫬㛫⏕≀Ꮫ9RO1R 