NATTOKINASE BENEFITS RESEARCH REPORT

Nattokinase is an enzyme produced during the fermentation of soybeans into thetraditional Japanese food called "natto." It is a fibrinolytic enzyme, meaning it has theability to break down fibrin, a protein involved in blood clot formation. Nattokinase has
gained attention for its potential health benefits, particularly in cardiovascular health.

Nattokinase offers several health benefits, particularly related to cardiovascular health,circulation, and potentially neurodegenerative diseases:
1. Cardiovascular Health:
Nattokinase may help maintain arterial health by reducing the progression ofatherosclerosis, which involves the hardening and narrowing of arteries due to fattybuildup. It has shown potential in lowering cholesterol and blood pressure levels, which
are key factors in heart disease risk.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043915/
Conclusion from the above research report:
Nattokinase (NK) has emerged as a promising natural compound with numerous
beneficial effects on cardiovascular health. It has been shown to reduce nasal polyptissue and holds potential for treating chronic rhinosinusitis. NK offers multiple benefits
for cardiovascular disease (CVD) patients, including thrombosis prevention,
hypertension control, atherosclerosis management, hyperlipidaemia reduction, platelet
aggregation inhibition, and neuroprotection. Its advantages over traditional CVD drugs
include high safety, low cost, ease of oral administration, a simple production process,and a long in vivo half-life.
NK is expected to become a next-generation drug for thrombotic disorders and CVDs,
potentially replacing multiple conventional medications like tPA, aspirin, warfarin, andnewer anticoagulants. However, further research is needed to establish its
pharmacokinetics, absorption, metabolism, and potential drug interactions. Despite
these challenges, the current data on NK is promising, suggesting it may simplify andimprove CVD management in the future.
2. Improving Circulation:
By breaking down fibrin and dissolving blood clots, nattokinase can enhance blood
flow, preventing clot formation, and thus improving overall circulation. This is crucial fordelivering oxygen and nutrients throughout the body and preventing complications likeperipheral artery disease and varicose veins.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879341/

Conclusion from the above research report:
Nattokinase (NK), a fibrinolytic enzyme derived from the traditional Japanese food natto,
has been widely studied for its cardiovascular health benefits. Research indicates that
NK can improve blood flow by breaking down fibrin, thereby reducing the formation ofblood clots and improving overall cardiovascular health. Additionally, NK has beenshown to help regulate blood pressure by inhibiting the angiotensin-converting enzyme,which reduces the risk of hypertension.
NK also demonstrates potential in managing cholesterol levels by decreasing totalcholesterol, LDL-C (bad cholesterol), and triglycerides, which helps prevent thedevelopment of atherosclerosis. The combination of NK with other substances like red
yeast rice has been found to enhance these benefits.
However, there are risks associated with NK use, including increased bleeding,particularly in individuals taking blood thinners or those with blood clotting disorders.NK
can interact with antihypertensive drugs, potentially leading to excessively low bloodpressure. Therefore, it is crucial to consult healthcare providers before starting NK
supplements, especially for individuals with preexisting conditions or those taking othermedications.
In summary, while NK holds promise as a natural alternative for managing
cardiovascular diseases, further research and clinical trials are necessary to fully
understand its benefits and risks.
3. Preventing Blood Clots:
Nattokinase exhibits a remarkable ability to prevent and dissolve blood clots by directlyreducing fibrin clots more efficiently than plasmin and increasing the activity ofanti-clotting enzymes. This makes it beneficial for individuals at a higher risk ofcardiovascular events caused by clotting.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4479826/
Conclusion from the above research report:
The study investigates the effects of nattokinase, a fibrinolytic enzyme from theJapanese food natto, on preventing blood clots, showing it significantly enhances
fibrinolysis, dissolves existing clots, and prevents new ones by reducing levels offibrinogen, factor VII, and factor VIII, thereby promoting better blood circulation.
Nattokinase's effectiveness is comparable to conventional anticoagulants but with fewer

side effects, indicating its potential as a safe dietary supplement for preventing
conditions like deep vein thrombosis and pulmonary embolism. While promising, further
clinical trials are necessary to establish standardized dosing, long-term safety, andefficacy across diverse populations, underscoring its potential in improving
cardiovascular health.

4. Reducing Inflammation:
With anti-inflammatory properties, nattokinase may help mitigate chronic inflammation's
negative effects on the cardiovascular system, lowering the risk of conditions likeatherosclerosis. https://pubmed.ncbi.nlm.nih.gov/32193146/
Conclusion from the above research report:
The research on nattokinase, an enzyme derived from fermented soybeans (natto),reveals its potential in disrupting the harmful cycle between inflammation, oxidative
stress, and coagulation. Specifically, nattokinase demonstrates significant
anti-thrombotic properties by inhibiting lipopolysaccharide (LPS)-induced inflammationand oxidative stress. This inhibition reduces the expression of inflammatory cytokines
and oxidative markers, thereby preventing the activation of coagulation pathways. The
study underscores the therapeutic promise of nattokinase in managing conditions
characterized by chronic inflammation and hypercoagulability, offering a novel approachto prevent thrombus formation and associated cardiovascular complications.
5. Neurodegenerative Disease Potential:
Although more research is needed, early studies suggest nattokinase could play a role
in reducing amyloid plaque levels associated with Alzheimer's disease, offering a
potential therapeutic application.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003083/
Conclusion:
Nattokinase, a potent enzyme derived from fermented soybeans, has shown promising
health benefits through various studies and clinical trials. As outlined in the preceding
sections, its mechanisms of action include enhancing fibrinolysis, improving blood
circulation, reducing inflammation, regulating blood pressure, and potentially providing
neuroprotective effects.

In conclusion, the accumulated evidence suggests that nattokinase holds considerable
potential in promoting cardiovascular health, preventing thrombotic events such as heart
attacks and strokes, alleviating inflammatory conditions, and even offering protection
against neurodegenerative diseases. Furthermore, its safety profile appears favorable,with minimal reported side effects.
However, despite these encouraging findings, further research is warranted to fully
elucidate the extent of nattokinase's benefits and its optimal clinical applications.
Rigorous clinical trials with larger sample sizes and longer durations are needed toconfirm its efficacy and safety across diverse populations. Additionally, exploring its
potential interactions with medications and its long-term effects should be priorities forfuture investigations.
In light of the growing interest in natural alternatives for health maintenance and disease
prevention, nattokinase stands out as a promising candidate. Continued research efforts
in this area have the potential to unlock further therapeutic applications and enhance
our understanding of this remarkable enzyme's role in human health.
*The information displayed herein has not been evaluated and/or approved in any formby the Japan Ministry of Health, FDA and/or similar body in Japan or elsewhere.