Curriculum Vitae
Shinji KISHIMOTO, Ph.D.
Assistant Professor
Department of Pharmaceutical Sciences, University of Shizuoka
Shizuoka 422-8526, JAPAN
Phone: +81-54-264-5662
Email: kishimoto@u-shizuoka-ken.ac.jp
APPOINTMENT
Department of Pharmaceutical Sciences, University of Shizuoka (Prof. Kenji WATANABE)
Assistant Professor
2022–present
Research Assistant Professor
2019–2022
Appointed Assistant Professor
2015–2019
EDUCATION
2015 Ph.D. Pharmaceutical Sciences, Kyoto University (Prof. Hideaki KAKEYA)
2012 M.S. Pharmaceutical Sciences, Kyoto University (Prof. Hideaki KAKEYA)
2010 B.S. Pharmaceutical Sciences, Kyoto University (Prof. Hideaki KAKEYA)
AWARDS
2022

2022 The JSP Award for Young Scientists
The Japanese Society of Pharmacognosy

20172017 Young Researcher’s Award
The Pharmaceutical Society of Japan, Division of Natural Medicines

Publications
Original Papers
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Shinji Kishimoto, Yuya Matsubara and Kenji Watanabe“Alkaloid biosynthetic enzyme generates diastereomeric pair via two distinct mechanisms”
J. Am. Chem. Soc., 144, 5485 (2022)
Takumi Okamoto, Shinji Kishimoto and Kenji Watanabe“Isolation of natural prodrug-like metabolite by simulating human prodrug activation infilamentous fungus”
Chem. Pharm. Bull., 70, 304 (2022)
Shinya Matsuda, Yuta Tsunematsu, Takuma Matsushita, Yuji Ogata, Shihomi Hachiya, ShinjiKishimoto, Noriyuki Miyoshi and Kenji Watanabe“Toward engineered biosynthesis of drugs in human cells”
ChemBioChem, 22, e202100645 (2022)
Michio Sato, Shinji Kishimoto, Mamoru Yokoyama, Cooper S. Jamieson, Kazuto Narita, Naoya
Maeda, Kodai Hara, Hiroshi Hashimoto, Yuta Tsunematsu, K. N. Houk, Yi Tang and KenjiWatanabe“Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels–Alderase”
Nat. Catal., 4, 223 (2021)

Schmeing, TM
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Takuma Kobayashi, Takeshi Toyoda, Yuya Tajima, Shinji Kishimoto, Yuta Tsunematsu, Michio
Sato, Kohei Matsushita, Takanori Yamada, Yuko Shimamura, Shuichi Masuda, Masako Ochiai,Kumiko Ogawa, Kenji Watanabe, Takeji Takamura-Enya, Yukari Totsuka, Keiji Wakabayashi andNoriyuki Miyoshi“o-anisidine metabolite in rat urine associated with urinary bladder carcinogenesis”
Chem. Res. Toxicol., 34, 912 (2021)
6. Takahiro Hamoya, Gen Fujii, Yosuke Iizumi, Takumi Narita, Masami Komiya, Yui Matsuzawa,
Kohei Miki, Tadashi Kondo, Shinji Kishimoto, Kenji Watanabe, Keiji Wakabayashi, Toshiyuki
Sakai, Jiro Toshima and Michihiro Mutoh“Artesunate inhibits intestinal tumorigenesis through inhibiting wnt signaling”
Carcinogenesis, 42, 148 (2021)
7. Takuma Matsushita, Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto and Kenji Watanabe“Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidasefrom Fungal Natural Product Biosynthesis”
Biochemistry, 59, 4787 (2020)
8. Shinji Kishimoto, Yuta Tsunematsu, Takuma Matsushita, Kodai Hara, Hiroshi Hashimoto, YiTang and Kenji Watanabe“Functional and Structural Analyses of trans C-Methyltransferase in Fungal Polyketide
Biosynthesis”
Biochemistry, 58, 3933 (2019)
9. Shinji Kishimoto, Kodai Hara, Hiroshi Hashimoto, Yuichiro Hirayama, Pier Alexandre
Champagne, Kendall N. Houk, Yi Tang and Kenji Watanabe“Enzymatic one-step ring contraction for quinolone biosynthesis”
Nat. Commun., 9, 2826 (2018).
10. Mamoru Yokoyama, Yuichiro Hirayama, Tsuyoshi Yamamoto, Shinji Kishimoto, Yuta
Tsunematsu and Kenji Watanabe“Integration of Chemical, Genetic, and Bioinformatic Approaches Delineates Fungal Polyketide—
Peptide Hybrid Biosynthesis”
Org. Lett., 19, 2002-2005 (2017).
11. Michio Sato, Jaclyn M. Winter, Shinji Kishimoto, Hiroshi Noguchi, Yi Tang and Kenji Watanabe“Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin
Biosynthesis”
Org. Lett., 18, 1446-1448 (2016)
12. Tsuyoshi Yamamoto,Yuta Tsunematsu, Kodai Hara, Tomohiro Suzuki, Shinji Kishimoto,Hirokazu Kawagishi, Hiroshi Noguchi, Hiroshi Hashimoto,Yi Tang, Kinya Hotta and KenjiWatanabe“Oxidative trans to cis Isomerization of Olefins in Polyketide Biosynthesis”
Angew. Chem. Int. Ed., 55, 6207-6210 (2016)13. Hiroki Kato, Yuta Tsunematsu, Tsuyoshi Yamamoto, Takuya Namiki, Shinji Kishimoto, Hiroshi
Noguchi and Kenji Watanabe“New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening andidentification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145”
J. Antibiot., 69, 561-566 (2016)14. Shinji Kishimoto, Shinichi Nishimura, Masaki Hatano, Masayuki Igarashi and Hideaki Kakeya“Total Synthesis and Antimicrobial Activity of Chlorocatechelin A”
J. Org. Chem., 80, 6076−6082 (2015)15. Shinji Kishimoto, Shinichi Nishimura and Hideaki Kakeya

Schmeing, TM“Total Synthesis and Structure Revision of Mirubactin, and Its Iron Binding Activity”
Chem. Lett., 44, 1303-1305 (2015)
16. Aya Yoshimura, Shinji Kishimoto, Shinichi Nishimura, Saori Otsuka, Yuki Sakai, Akira Hattoriand Hideaki Kakeya.
“Prediction and Determination of the Stereochemistry of the 1,3,5-Trimethyl-Substituted Alkyl
Chain in Verucopeptin, a Microbial Metabolite”
J. Org. Chem., 79, 6858-6867 (2014).
17. Shinji Kishimoto, Shinichi Nishimura, Akira Hattori, Masafumi Tsujimoto, Masaki Hatano,
Masayuki Igarashi and Hideaki Kakeya“Chlorocatechelins A and B from Streptomyces sp.: New Siderophores Containing ChlorinatedCatecholate Groups and an Acylguanidine Structure”
Org. Lett., 16, 6108-6111 (2014)18. Shinji Kishimoto, Yuta Tsunematsu, Shinichi Nishimura, Yutaka Hayashi, Akira Hattori andHideaki Kakeya“Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.”
Tetrahedron, 68, 5572-5578 (2012).
Reviews
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Michio Sato, Shinji Kishimoto, Hiroshi Noguchi and Kenji Watanabe“2.17 - Bisindole, Comprehensive Natural Products III”
Chemistry and Biology, Wiley 2020, 2, 467.
Shinji Kishimoto, Yuichiro Hirayama and Kenji Watanabe“Polyketide Synthase–Nonribosomal Peptide Synthetase Hybrid Enzymes of Fungi”
The Mycota, XV: Physiology and Genetics (2018).
Shinji Kishimoto, Yuta Tsunematsu, Michio Sato and Kenji Watanabe“Elucidation of biosynthetic pathways of natural products”
Chem. Rec. 17, 1-15 (2017).
Shinji Kishimoto, Michio Sato, Yuta Tsunematsu and Kenji Watanabe“Evaluation of Biosynthetic Pathway and Engineered Biosynthesis of Alkaloids”
molecules, 21, 1078-1096 (2016).