㻞㻜㻝㻠 ᖺᗘ㻌 ྕእ㻌㻞㻜㻝㻠㻚㻜㻤㻚㻜㻡 Ⓨ⾜‫ޛ‬ӝ‫ܖ᧓଺ ܖٻ‬ᄂᆮ৑ȋȥȸǺȬǿȸ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭˳ϋ଺ᚘƴ᧙Ƣǔஇૼ঺ௐᲬ‫إ‬Ყ ԗ஖ᧈǛൿǊǔȡǫȋǺȠ ᲧᲧ ǤȳǹȪȳƴǑǔ଺Цᛦራ Ყஜᄂᆮ৑ƷଢჽᄂᆮܴƷஇૼ঺ௐƕ %GNN 2TGUU ƷБᘍƢǔǪȳȩǤȳǸȣȸȊȫ %GNN 4GRQTVU ƴ  ࠰  உ  ଐᲢᛯ૨ #MCUJKGVCNᲣŴ உ  ଐᲢᛯ૨Წ5CVQGVCNᲣƴਫ਼᠍ƞǕǇƠƨŵᛯ૨ᲫưƸŴȔȪǪȉƱԠƹǕǔ଺ᚘᢡˡ‫܇‬ငཋƕ˳ϋ଺ᚘǛನ঺Ƣǔ‫܇׆‬ƷƏƪžᢡˡ‫܇‬Ʒ৮С‫܇׆‬ſƷ΁ƖǛɟ଺ႎƴ໯щ҄ƢǔƜƱƴǑƬƯž଺᧓Ʒ᡿ǕſǛƭƘǓЈƠŴ˳ϋ଺ᚘƷኖ  ଺᧓ƱƍƏᧈƍԗ஖Ʒဃ঺ƴࢫᇌƬƯƍǔƜƱǛଢǒƔƴƠǇƠƨ ᘻ᩿ᚐᛟĬ ŵƜƷᄂᆮ঺ௐƸ˳ϋ଺ᚘƷԗ஖ᧈǛൿǊǔȡǫȋǺȠǛᚐଢƠŴ଺᧓ဃཋ‫ܖ‬ƷؕᄽᄂᆮƷႆ‫ޒ‬ƴᝡྂƢǔǋƷưƢŵᛯ૨  ưƸŴଷ᧓Сᨂዅ᫲வˑɦƷȞǦǹƴŴ᫢ʙЭƴǤȳǹȪȳཎီႎ᧹ܹдǛ৲ɨƠƯ˳ϋ଺ᚘǛᚇ‫ݑ‬ƠƨኽௐŴǤȳǹȪȳƕᏁᐥƷ˳ϋ଺ᚘǛᛦራƠƯƍǔƜƱǛଢǒƔƴƠǇƠƨ ᘻ᩿ᚐᛟĭ ŵƜƷᄂᆮ঺ௐƸ᫢ʙƴǑǔ˳ϋ଺ᚘƷᛦራೞನƷμܾᚐଢƴࢫᇌƭƜƱƕ஖ࢳƞǕǇƢŵƜǕǒƷᄂᆮƸଢჽ૙੉ƕᄂᆮˊᘙᎍǛƭƱǊǔஇέᇢȷഏɭˊᄂᆮ᧏ႆૅੲȗȭǰȩȠƷя঺ǛӖƚƯᘍǘǕǇƠƨŵ ᛯ૨ᲫAkashi M, Okamoto A, Tsuchiya Y, Todo T, Nishida E, Node K. A Positive Role for PERIOD in Mammalian Circadian GeneExpression. Cell Reports 7(4): 1056–1064, 2014.
ᛯ૨ᲬSato M, Murakami M, Node K, Matsumura R, Akashi M. The Role of the Endocrine System in Feeding-Induced
Tissue-Specific Circadian Entrainment. Cell Reports, Published online (July 10, 2014), DOI: 10.1016/j.celrep.2014.06.015
ŭˌɥƷᄂᆮ঺ௐƸ‫׎‬ϋ‫ٳ‬ƷȡȇǣǢưǋ࠼Ƙ‫إ‬ᢊƞǕǇƠƨŵᲶ‫׎‬ϋᲸȷᛠ٥ૼᎥƀ˳ϋ଺ᚘԗ஖ƷˁኵǈᚐଢžȔȪǪȉƨǜƺƘឋſ˺ဇƁ  ࠰  உ  ଐ ȷɶ‫ૼ׎‬ᎥƀǤȳǹȪȳƕ˳ϋ଺ᚘᛦራƁ  ࠰  உ  ଐ ȷᛠ٥ૼᎥƀǤȳǹȪȳ˳ϋ଺ᚘᛦራ ᫢ʙ᧙̞Ʒᐥ֥ƴ˺ဇ ‫ޛ‬ӝ‫ٻ‬૙੉ǒᚐଢƁ  ࠰  உ  ଐ ȷᛠ٥ૼᎥƷҔၲǵǤȈ ;QOK&TƀǤȳǹȪȳ˳ϋ଺ᚘᛦራ ‫ޛ‬ӝ‫ٻ‬૙੉ǒᚐଢƁ  ࠰  உ  ଐ ȷ;CJQQ ȋȥȸǹƀ‫ޛ‬ӝ‫ٻ‬Ŵ᫢ʙƴǑǔ˳ϋ଺ᚘƷᛦራƴǤȳǹȪȳƕ᧙ɨƠƯƍǔƜƱǛႆᙸƁ  ࠰  உ  ଐ Ჶෙ‫ٳ‬Ჸ
ȷ6+/'ß;QWT(QQF+PHNWGPEGU;QWT$QF[ÞU+PVGTPCN%NQEMà  ࠰  உ  ଐ 
ȷ6JG6KOGUß#HT[WRDGHQTGVCMGQHHKUQPGYC[VQCXQKFLGVNCIà  ࠰  உ  ଐ ȷ0$%6QFC[ß5NGGRRTQDNGOU!%CTDUCVPKIJV᳽DWVPQVVQQNCVG᳽OC[JGNRà  ࠰  உ  ଐ ȷ6JG*WHHKPIVQP2QUVß)QV,GV.CI!(QQF%JQKEGU%CP*GNR#PF*GTG U*QY#EEQTFKPI6Q0GY5VWF[à  ࠰  உ  ଐ 
ȷ6GNGITCRJß%QWNFUPCEMKPIJGNR[QWDGCVLGVNCI!à  ࠰  உ  ଐ 
ȷ&CKN[/CKNß#DKIDTGCMHCUVDGHQTGHN[KPIKUQPGYC[VQDGCVLGVNCI %CTDNQCFKPI EQWNFTGUGVRCUUGPIGTU DQF[ENQEMUQPCNQPIJCWNVTKRà  ࠰  உ  ଐ ȷ0GY5EKGPVKUVß(QQFKPHNWGPEGUDQF[ENQEMCPFOC[GCUGLGVNCIà  ࠰  உ  ଐ 
ȷ&KUEQXGTß,GV.CI5PCEMU*QY(QQFU#HHGEV;QWT$QF[ÞU+PVGTPCN%NQEMà  ࠰  உ  ଐ ŭᛯ૨ᲬƸŴ7%.# Ʒ ,QUGRJ2KUGIPC ૙੉Ʒਖ਼ᕟƴǑǓ (2TKOG ƴᢠ‫ܭ‬ƞǕǇƠƨŵJVVRHEQORTKOGVJGHCEWNV[OGODGTᲢ( ƸŴᄂᆮᎍƕᛠǉǂƖᛯ૨ǛᢠƿᨥƷɟƭƷਦ೅ƱƳƬƯƍǇƢŵ( ƷᢠᎋՃƸȎȸșȫចӖចᎍŴ4Q[CN 5QEKGV[ȕǧȭȸŴ0#5 ȡȳȐȸƳƲԃǉȈȃȗᄂᆮᎍƔǒನ঺ƞǕŴᢠƹǕǔƷƸଐŷЈ༿ƞǕǔᛯ૨ƷƏƪƷ ᲟƱƳƬƯƓǓǇƢŵᲣᚐ ᛟ Ĭ˳ϋ଺ᚘƷԗ஖ᧈǛൿǊǔȡǫȋǺȠ
Akashi et al. (2014) Cell Reports 7(4): 1056–1064. ኖ  ଺᧓Ʒ˳ϋȪǺȠǛƭƘǔ˳ϋ଺ᚘᲢ‫ᧉݦ‬ႎƴƸಒଐ଺ᚘƱǑƹǕǔᲣƴǑƬƯŴᅶƨƪƷ˳Ƹზ჈ᙾᣧǛƸơǊƱƢǔಮŷƳ៲˳ೞᏡƷኖᲫଐƷ‫٭‬ѣǛᅆƢŵᅶƨƪƷ៲˳ೞᏡƸᢡˡ‫܇‬ƕዌƑƣ΁ƘƜƱƴǑƬƯСࣂƞǕƯƍǔƕŴ˳ϋ଺ᚘƷࢫлƸƜǕǒૠ‫ٶ‬ƘƷᢡˡ‫܇‬Ʒ෇ࣱƴƓƍƯኖᲫଐƷȪǺȠǛႆဃƞƤǔƜƱưƋǔŵƦǕƴǑƬƯŴᅶƨƪƷƋǓƱƋǒǏǔ៲˳ೞᏡƴƓƍƯȪǺȠƕƏǇǕǔŵ˳ϋ଺ᚘǛನ঺Ƣǔ‫܇׆‬ƸŴžᢡˡ‫܇‬Ʒ෇ࣱ҄‫܇׆‬ſƱžᢡˡ‫܇‬Ʒ৮С‫܇׆‬ſƷᲬƭƴ‫ٻ‬КƞǕǔŵƜǕǒƕʩʝƴ˺ဇƢǔƜƱưŴૠŷƷᢡˡ‫܇‬Ʒ෇ࣱƴƓƍƯɟଐƷȪǺȠƕƭƘǒǕǔƷưƋǔŵƭǇǓŴ෇ࣱ҄‫܇׆‬ƕᢡˡ‫܇‬Ǜ෇ࣱ҄ƢǔƕŴ଺᧓ƱƱǋƴ‫ف‬ьƠƨ৮С‫܇׆‬ƕ෇ࣱ҄‫܇׆‬ƷೞᏡǛ৮СƢǔŵ଺᧓ƕኺƭƱƱǋƴ৮С‫܇׆‬ƸƠƩƍƴЎᚐƞǕŴϐƼ෇ࣱ҄‫܇׆‬ƕᢡˡ‫܇‬Ǜ෇ࣱ҄ƢǔŵƠƔƠƳƕǒŴᡫࠝƷ҄‫ܖ‬ӒࣖᡮࡇƷᎋƑ૾ƴǑǔƱŴኖ  ଺᧓ƱƍƏᧈƍԗ஖ǛਤዓႎƴƭƘǓЈƢƴƸ˴ƔཎКƳȡǫȋǺȠƷ‫נ܍‬ƕ࣏ᙲưƋǔƱᎋƑǒǕƯƖƨŵ঻ŷƕදႸƠƨƷƸŴ ࠰ƴிʮ‫ܖٻ‬ƷǰȫȸȗƴǑƬƯႆᙸƞǕƨȔȪǪȉƱƍƏ଺ᚘᢡˡ‫܇‬ƕᚨᚘƢǔǿȳȑǯឋưƋǔŵƜƷǿȳȑǯឋƸŴ˳ϋ଺ᚘƕദࠝƴೞᏡƢǔƨǊƴ࣏᪰ƷᢿԼưƋǔƜƱƕǘƔƬƯƍƨƕŴƦƷࢫлƴƭƍƯƸჳႽǍɧଢƳໜƕ‫ٶ‬ƔƬƨŵଢჽ૙੉ǒƷᄂᆮǰȫȸȗƸŴƜƷȔȪǪȉƸŴ˳ϋ଺ᚘǛನ঺Ƣǔ‫܇׆‬ƷƏƪžᢡˡ‫܇‬Ʒ৮С‫܇׆‬ſƷ΁ƖǛɟ଺ႎƴ໯щ҄ƢǔƜƱƴǑƬƯž଺᧓Ʒ᡿ǕſǛƭƘǓЈƠƯƓǓŴ˳ϋ଺ᚘƷኖ  ଺᧓ƱƍƏᧈƍԗ஖ǛƭƘǓЈƢƨǊƴࢫᇌƬƯƍǔƜƱǛଢǒƔƴƠƨŵᚐᛟᲴଢჽ Ⴧ ଺᧓‫ܖ‬ᄂᆮ৑ȷ૙੉ ‫ࢼ  ׋‬ஹƷ˳ϋ଺ᚘƷȡǫȋǺȠƷȢȇȫᚐ ᛟ ĭ‫ ׋‬ž଺᧓Ʒ᡿ǕſǛ˺ǓЈƢˁኵǈƷǤȡȸǸಒଐ଺ᚘǛᛦራƢǔǤȳǹȪȳ

Sato et al. (2014) Cell Reports, Published online (July 10, 2014), DOI: 10.1016/j.celrep.2014.06.015.
 ƍǘƣǋƕƳǤȳǹȪȳƸ᫢ࢸƴᘉኄ͌ǛᛦራƢǔƜƱưǑƘჷǒǕƯƍǔțȫȢȳưƋǔŵಒଐ଺ᚘƸኖ  ଺᧓ԗ஖ƷಒଐȪǺȠǛဃǈЈƢ˳ϋ଺ᚘưƋǓŴஇᡈ঻ŷƸǤȳǹȪȳƕᏁᐥƱᏢᏆኵጢƷಒଐ଺ᚘǛᛦራƠƯƍǔƜƱǛଢǒƔƴƠƨŵ᫢ʙƕಒଐ଺ᚘǛᛦራƢǔӧᏡࣱƕᅆՐƞǕƨƷƸŴ ࠰ŴǢȡȪǫƷ࣎ྸ‫ܖ‬ᎍ %WTV4KEJVGT ƴǑƬƯưƋƬƨŵ‫ٸ‬ᘍࣱưƋǔȞǦǹƸƍƭưǋ᫲Ǜ᫢ǂǒǕǔவˑɦưƸଢ଼ƍ଺᧓࠘ƴ‫ڤ‬ǜư᫢ǂǔŵƠƔƠŴ᫲Ǜଢǔƍ଺Цƴᨂ‫ܭ‬ƠƯɨƑǔᲢଷ᧓Сᨂዅ᫲ᲣƱŴȞǦǹƷ෇ѣƸዅ᫲Ʒૠ଺᧓ЭƔǒ෇ႆ҄ƢǔǑƏƴƳǓŴ‫଺ܭ‬ƴ᫲ǛࢽǒǕƳƘƯǋƦƷʖ஖ᘍѣƸૠଐዓƍƨƷưƋǔŵଷ᧓Сᨂዅ᫲ƸƦƷࢸ‫ٶ‬ƘƷᄂᆮᎍǛ᭽ʕƠŴଷ᧓Сᨂዅ᫲ƕ෇ѣ᣽ƷǈƳǒƣ˳ภǍƞǇƟǇƳțȫȢȳƷଐԗ‫٭‬ѣŴƞǒƴƸƋǒǏǔᐥ֥Ʒಒଐ଺ᚘǛǋᛦራƢǔƜƱƕǘƔƬƯƖƨŵ᫢ʙƷ˴ƕƜƏƠƨ‫҄٭‬ǛǋƨǒƠƯƍǔƷƩǖƏƔŵ঻ŷƸଷ᧓Сᨂዅ᫲வˑɦƷȞǦǹƴ᫢ʙЭƴǤȳǹȪȳཎီႎ᧹ܹдǛ৲ɨƠŴಒଐ଺ᚘǛᚇ‫ݑ‬ƠƨŵƢǔƱŴᏁᐥƷಒଐ଺ᚘƷዅ᫲଺ЦǁƷӷᛦӒࣖƕ᡿ƘƳƬƨŵǇƨŴᏁᐥƱᏢᏆኵጢǛኵጢؔ᫱ɦƴƓƍƯǤȳǹȪȳưХນƠŴǤȳǹȪȳƕಒଐ଺ᚘƷ଺ЦǛžႺ੗ſѣƔƢƜƱǛଢǒƔƴƠƨŵƞǒƴŴǤȳǹȪȳƴǑǔᏁᐥƷ଺ЦᛦራƴƸ᫢᫲଺Цƴ̔‫܍‬Ơƨ૾ӼࣱƕƋǓŴଢǔƍ଺ЦƷЭҞưƸ଺ᚘǛ᡿ǒƤǔ૾Ӽƴ˺ဇƠƯƍǔƜƱƕǘƔƬƨŵˌɥŴǤȳǹȪȳƕ᫢ʙƴˤƬƯಒଐ଺ᚘǛᛦራƠƯƍǔƜƱƕଢǒƔƱƳƬƨŵƠƔƠƳƕǒŴஜᄂᆮưǤȳǹȪȳཎီႎ᧹ܹдǛ৲ɨƠƯƍƯǋᏁᐥưƷӷᛦӒࣖƕෞ‫ڂ‬ƸƤƣŴǤȳǹȪȳ᩼ज़ӖࣱƷኵጢưƸǤȳǹȪȳ৲ɨƴǑǔ଺ЦᛦራƕǄƱǜƲᛐǊǒǕƳƔƬƨŵƜǕǒƷƜƱǑǓŴ᫢ʙƴǑǔಒଐ଺ᚘƷᛦራƸǤȳǹȪȳˌ‫ٳ‬ƴǋᙐᩃƳೞࡀǛԃǜưƍǔƱᎋƑǒǕŴʻࢸ‫  ׋‬ǤȳǹȪȳƕ᫢ࢸƴ˳ϋ଺ᚘǛᛦራƢǔȡǫȋǺȠƸƦƷμܾᚐଢƕ൭ǊǒǕǔŵᚐᛟᲴ˱ᕲ ፦ᆞ ଺᧓‫ܖ‬ᄂᆮ৑ȷཎԡя૙