RheinischeFriedrich-WilhelmsUniversität Bonn

ImmunoSensation
the immune sensory system
Bonn cluster of excellence

Program Cluster Science Days 2018, Nov 05 & 06, 2018
This symposium is also organized as "the 10th International Symposium of IFReC”

Monday, November 05, 201808:00 – 09:00

Registration, mounting of posters & coffee

09:00 – 09:30

Opening remarks

09:30 – 10:00

New CAR T cell therapy for multiple myeloma (Prof. Naoki Hosen, Cancer Stem Cell Biology,

IFReC Speaker

10:00 – 10:25
PI Talk Bonn

10:25 – 10:40
Selected from abstracts

10:40 – 11:0011:00 – 11:30
IFReC Speaker

11:30 – 11:55
PI Talk Bonn

11:55 – 12:15
Early Career Talk

12:15 – 12:45
IFReC Speaker

Osaka University Graduate School of Medicine, Japan)

CRISPitope: A Versatile Approach To Study How The Target Antigen Choice Influences
Antigen-Specific T-cell Therapy (Prof. Michael Hölzel, Institute of Clinical Chemistry andClinical Pharmacology, University of Bonn, Germany)

Creld1 Regulates T Cell Survival And Fate In Mouse And Human Via Regulation Of The
Wnt/ β-Catenin Pathway (Lorenzo Bonaguro, Genomics and Immunoregulation, LIMESInstitute, University of Bonn, Germany)

Coffee BreakBone marrow microenvironmental niches for hematopoietic stem cells and immune cells(Prof. Takashi Nagasawa, Stem Cell Biology and Developmental Immunology, Immunology
Frontier Research Center, Osaka University, Japan)

Spatio-temporal Regulation of Leukocyte chemotaxis (Prof. Waldemar Kolanus, MolecularImmunology and Cell Biology, LIMES Institute, University of Bonn, Germany)

Can centrosome numbers shape immune responses? (Prof. Eva Kiermaier, Immune andTumor Biology, LIMES Institute, University of Bonn, Germany)

Regulation of immune responses via C-type lectin receptors (Prof. Sho Yamasaki,Molecular Immunology, Immunology Frontier Research Center, Osaka University, Japan)

12:45 – 13:30

Lunch

13:30 – 14:00

Host-microbiota interaction in the intestine (Prof. Kiyoshi Takeda, Mucosal Immunology,IFReC Speaker

14:00 – 14:25

Immunology Frontier Research Center, Osaka University, Japan)

Environmental control of mucosal immunity and metabolism by the AhR/AhRR pathway

PI Talk Bonn

(Prof. Irmgard Förster, Immunology and Environment, LIMES Institute, University of Bonn,Germany)

14:25 – 14:45

Metabolic Fuelling of Barrier Immunologie (Prof. Christoph Wilhelm, Institute of Clinical

Early Career Talk14:45 – 15:00

Chemistry and Clinical Pharmacology, University of Bonn, Germany)

Lipid Droplet Formation Fuels Pathogenic ILC2 Responses In Airway Inflammation

Selected from abstracts(Schekufe Kharabi-Masouleh, Institute of Clinical Chemistry and Clinical Pharmacology, Universityof Bonn, Germany)

15:00 – 15:15

Lung-specific Innate Immune Memory Controls Reactivity Of Mononuclear Phagocytes
To Acute And Chronic Inflammation (Dr. Natalie Katzmarski, Myeloid Cell Biology, LIMES

Selected from abstracts

15:15 – 15:30
Selected from abstracts

Institute, University of Bonn, Germany)

Neutrophils With An Extravasation Phenotype Are Detectable In The Peripheral BloodOf Patients With Chronic Obstructive Pulmonary Disease (Dr. Theodore Kapellos,Genomics and Immunoregulation, LIMES Institute, University of Bonn, Germany)1RheinischeFriedrich-WilhelmsUniversität Bonn

ImmunoSensation
the immune sensory system
Bonn cluster of excellence

15:30 – 16:25

Poster Session with Coffee

16:25 – 16:50

Posttranscriptional regulation of NLR family members (Prof. Eicke Latz, Institute of Innate

PI Talk Bonn

Immunity, University of Bonn, Germany)

Selected from abstracts

Platelets Boost Inflammasome-Derived IL-1 Cytokines By Regulating NLRP3Expression (Verena Rolfes, Institute of Innate Immunity, University of Bonn, Germany)

17:05 – 17:20

Alternative Splicing: an Alternative Level of NLRP3 Inflammasome Regulation (Florian

16:50 – 17:05

Selected from abstracts

Hoss, Institute of Innate Immunity, University of Bonn, Germany)

17:20 – 17:30

Coffee Break

17:30 – 18:30

Keynote Address
Regulatory T cells in autoimmunity

Keynote IFReC(Prof. Shimon Sakaguchi, Experimental Immunology, Immunology Frontier Research Center,
Osaka University, Japan)

Bonn Technology Campus Reception (BMZ) & Speakers' Dinner (Marriott)2

RheinischeFriedrich-WilhelmsUniversität Bonn

ImmunoSensation
the immune sensory system
Bonn cluster of excellence

Tuesday, November 06, 2018

09:00 – 09:25
PI Talk Bonn

09:25 – 09:55
IFReC Speaker

09:55 – 10:15
Early Career Talk

10:15 – 10:30

Nucleic acid immunity: overview and recent insights (Prof. Gunther Hartmann, Institute ofClinical Chemistry and Clinical Pharmacology, University of Bonn, Germany)

Paired receptors in host-pathogen interaction (Prof. Hisashi Arase, Immunochemistry,Immunology Frontier Research Center, Osaka University, Japan)

G-quadruplexes and their implication in biology (Prof. Katrin Paeschke, Medical Clinic III forOncology, Hematology and Rheumatology, University Hospital Bonn, Germany)

DNA Inflammasome Formation In Human Myeloid And Non-Myeloid Cells (Maximilian

Selected from abstracts

Nastaly, Institute of Clinical Chemistry and Clinical Pharmacology, University of Bonn, Germany)

10:30 – 10:45
Selected from abstracts

NLRP3 is The Innate Immune Sensor for Clostridium difficile Toxins A and B in HumanMacrophages (Dr. Matthew Mangan, Institute of Innate Immunity, University of Bonn, Germany)

10:45 – 11:05

Coffee break

11:05 – 11:35

Regulation of B cell tolerance by epigenetic factors (Prof. Tomohiro Kurosaki, Lymphocyte

IFReC Speaker

11:35 – 12:05

Differentiation, Immunology Frontier Research Center, Osaka University, Japan)

Variation and adaptation in innate immune responses (Prof. Mihai Netea, Immunology andPI Talk Bonn/
Keynote Bonn

Metabolism, LIMES Institute, University of Bonn, Germany & Experimental Medicine, Departmentof Internal Medicine, Nijmegen University Medical Center, The Netherlands)

12:05 – 12:25

Understanding human innate immune training (Dr. Andreas Schlitzer, Myeloid Cell Biology,

Early Career Talk

12:25 – 12:50
PI Talk BonnLIMES Institute, University of Bonn, Germany)

Rule-based data-informed generation of cellular consensus maps (Prof. Joachim L.
Schultze, Genomics and Immunoregulation, LIMES Institute, University of Bonn, Germany)

12:50 – 13:35

Lunch

13:35 – 14:00

The endocannabinoid system in ageing and age-related disorders (Prof. Andreas Zimmer,

PI Talk Bonn

14:00 – 14:15
Selected from abstracts

14:15 – 14:40
PI Talk Bonn

14:40 – 14:55

Institute of Molecular Psychiatry, University of Bonn, Germany)

The Role of the Cannabinoid Receptor 1 in Stress-induced Inflammation and Behaviour(Eva Beins, Institute of Molecular Psychiatry, University of Bonn, Germany)

Innate Immune activation in Alzheimer's disease (Prof. Michael Heneka, Department ofNeurodegenerative Diseases & Gerontopsychiatry/ Neurology, University Hospital Bonn,Germany)

NLRP3 Knockout Protects From Tau Pathology In Tau22 Mice (Dr. Christina Ising,Selected from abstracts

Department of Neurodegenerative Diseases & Gerontopsychiatry/ Neurology, University HospitalBonn, Germany)

14:55 – 15:50

Poster Session with Coffee

15:50 – 16:05

Murine Eosinophil Extracellular Traps mediate entrapping of Microfilariae of the Rodent
Filarial Nematode Litomosoides sigmodontis (Alexandra Ehrens, Institute of Medical

Selected from abstracts

Microbiology, Immunology and Parasitology, University of Bonn, Germany)3

RheinischeFriedrich-WilhelmsUniversität Bonn

16:05 – 16:20
Selected from abstracts

16:20 – 16:40
PI Talk Bonn/
Translational group

16:40 – 17:05
PI Talk Bonn

Institute, University of Bonn, Germany)

Type I IFN in liver fibrosis; an indisputable harassing factor (Dr. Zeinab Abdullah, Institute ofExperimental Immunology, University of Bonn, Germany)

Constitutive RIG-I Activation Causes Skin Lesion Resembling Psoriasis in Mice (Prof.
Hiroki Kato, Institute of Cardiovascular Immunology, University of Bonn, Germany)

Coffee break

17:15 – 18:15

Keynote Address
RNA degradation controls inflammation

18:15 – 18:45

the immune sensory system
Bonn cluster of excellence

Dietary Salt Consumption Induces a Specific Proinflammatory Response in theMacrophage Compartment (Dr. Buqing Yi, Molecular Immunology and Cell Biology, LIMES

17:05 – 17:15

Keynote IFReC

ImmunoSensation(Prof. Shizuo Akira, Host Defence, Immunology Frontier Research Center, Osaka University,Japan)

Awards & Closing remarks

Congress Party (Stella Rheni)4