1The Neurobiology of Mental Health
Lake Conference
Thun, May 12-16, 2024
Sunday, May 12
Arrival / Registration; Buffet dinner starting at 18:30

Monday, May 13
9:00-9:35 Naomi Wray (Univ. Queensland) Genetic architecture of psychiatric disorders
9:35-10:10 Daniel Geschwind (UCLA) Tackling heterogeneity in neuropsychiatric disorders through highthroughput biology.
Coffee10:30-11:05 Weizhe Hong (UCLA) Neural basis of prosocial behavior
11:05-11:40 Nancy Padilla-Coreano (Univ. Florida) Neural circuits underlying social competence in mice
11:40-11:55 Xiaoke Chen (Stanford) Unveiling the role of retinal processing in empathetic pain and autism
11.55-12:10 Tilmann Achsel (Univ. Lausanne) Identification of a sociability signature in the dorsal striatum
12:10-12:30 Camilla Bellone/Marie Schaer (Univ. Geneva) Translational research approach to social orienting deficits inautism: the role of superior colliculus-ventral tegmental pathway

Lunch 12:30-14:30

14:30-15:05 Hongkui Zeng (Allen Inst.) Transcriptomic changes of cell types in development, aging and disease
15:05-15:40 Sergiu Pasca (Stanford) Constructing and deconstructing the human nervous system to understanddisease15:40-16:15 Paola Arlotta (Harvard) Brain organoids as avatars to study human brain development and disease

Coffee16:35-17:10 Deanna Barch (Washington Univ.) Developmental risk factors for psychosis emergence
17:10-17:45 Beatriz Rico (KCL, London) Cortical interneuron dysfunction and neurodevelopmental disorders
17:45-18:00 Martin Munz (IOB, Basel) Layer 5 pyramidal neuron circuits at the inception of neocortex in the living mouseembryo
18:00-18:15 Matthew Johnson (Broad Inst.) A comparative atlas of cell states and molecular vulnerability to mental illness inthe adolescent prefrontal cortex

dinner 18:30-20:30

20:45-21:20 Kelsey Martin (Simons SFARI, UCLA) From synaptic plasticity to autism research

Poster Session I (A-K)

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Tuesday, May 14
9:00-9:35

Nadine Gogolla (MPI Munich) Whole-brain emotion state coding in mice

9:35-10:10 Catherine Dulac (Harvard) Neurobiology of sickness behavior
10:10-10:25 Adam Kepecs (Washington Univ.) Bridging bodily and mental illness: A neuro-immune circuit mediates cancer
cachexia-induced apathy
10:25-10:40 Tatiana Korotkova (Univ. Koeln) Regulation of anxiety by leptin receptor-expressing hypothalamic neurons inhealth and in anorexia modelCoffee
11:00-11:35 Kay Tye (Salk) Longitudinal visualization of stress Induced anhedonia
11:35-12:10 Michael Bruchas (Univ. Washington) A diverse network of pericoerulear neurons control arousal andstress states
11:10-12:25 Adelaide Minerva (Princeton) Cellular resolution changes in the ventral tegmental area underlying susceptibility
and resilience to chronic social stresslunch 12:30-14:30

14:30-15:05 Christian Luescher (Univ. Geneva) Dopamine transients in the nucleus accumbens instructing

reward choice
15:05-15:20 Iskra Pollak Dorocic (Stockholm Univ.) Mapping the transcriptional effects of SSRI treatment on serotoninsubtypes
15:20-15:35 Clara Liao (Yale) 5-HT2A dependent effects underpinning the action of psilocybin

Coffee15:55-16:30 Steve McCarroll (Harvard) The Synaptic Neuron-and-Astrocyte Program (SNAP)
16:30-17:05 Misha Ahrens (Janelia) Flexible computation in brainwide neuron-astrocyte zebrafish circuits
17:05-17:40 Hailan Hu (Zhejiang Univ.) The region-specific effect of ketamine and neuron-glia crosstalk in lateralhabenula
17:40-17:55 Marc Duque-Ramirez (Harvard) Ketamine induces plasticity in a norepinephrine-astroglial circuit to promote
behavioral perseverance in zebrafish

dinner 18:30-20:30

20:45-21:20 Bryan Roth (UNC Chapel Hill) Ultra-large-scale approaches for discovering transformative CNS

therapeutics

Poster Session II (L-Z)

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Wednesday, May 15
9:00-9:35 Akira Sawa (Johns Hopkins) Multimodal, longitudinal study for psychotic disorders: homeostatic

signaling to neural connectivity
9:35-10:10 Kevin Mastro/B. Stevens (Broad Inst.) Cellular mechanisms of adolescent development andpsychiatric vulnerability
10:10-10:25 Flurin Cathomas (Univ. Zurich) Circulating myeloid-derived MMP8 in stress susceptibility and depression
10:25-10:40 Yeong Shin Yim (Univ. Penn.) Non-conventional CD8+ T cells engage in brain homeostasis

Coffee11:00-11:35 Katharina Schmack (Crick, London) Hallucinating mice, dopamine and immunity: towards

mechanistic treatments for psychosis
11:35-12:10 Jonathan Flint (UCLA) A complementation test to find the genes involved in altering behavior anddisease risk

lunch 12:30-14:30
14:30-15:05 David Redish (Univ. Minn.) Episodic imagination in approach-avoid conflicts: implications for worry

and anxiety
15:05-15:40 David Kupferschmidt/ J. Gordon (NIMH) Optical reshaping of hippocampal-prefrontal

communication
15:40-16:15 Georg Keller (FMI, Basel) A cortical circuit approach to psychosis
16:15-16:30 Sam Vesuna (Stanford) Deep posteromedial cortical rhythm in dissociation

Coffee16:50-17:25 Nolan Williams (Stanford) Interventional neuropsychiatry
17:25-18:00 Edward Chang (UCSF) Closed-loop brain pacemakers for neuropsychiatric conditions
18:00-18:15 Irene Rembado (Allen Inst.) Cell type-specific and area-dependent effects in cortex to sinusoidal electric
stimulation in-vivo
18:15-18:30 Kristin Raj (Stanford) SAINT in the treatment of bipolar depression

dinner 18:45-20:45

Posters (All)4
Thursday, May 16
9:00-9:35 Chris Walsh (Harvard) You contain multitudes: somatic mutation in human neuropsychiatric disease
9:35-10:10 Elise Robinson (Broad Inst.) From genes to biology for autism

Coffee10:30-11:05 Michael Gandal (Univ. Penn.) Interpreting neuropsychiatric genetics through the lens of human braindevelopment
11:05-11:40 Mauro Costa-Mattioli (Baylor) Harnessing evolution and proteostasis networks to reverse cognitive

dysfunction
lunch 12:00-14:00

Departure