12
3
4

Adipocyte-specific inhibition of Mir221/222 ameliorates diet-induced obesity

5through targeting Ddit4

678

Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke

9

Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, and Jun Wada

1011

Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama

12

University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,

13

Okayama, Japan

14
15
16
17

Correspondence:18

Jun Wada, M.D., Ph.D.

19

Department of Nephrology, Rheumatology, Endocrinology and Metabolism

20

Okayama University

21

2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan

22

Tel: +81-86-235-7232

23

FAX: +81-86-222-5214

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25

E-mail: junwada@okayama-u.ac.jp26
27

Keywords: Non-coding RNAs, microRNA, Adipose Tissues, Adipogenesis, mTORC1

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ABSTRACT

32

MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target

33

mRNAs in obesity, but miRNAs critically involved in this process is not well characterized.

34

Here, we identified upregulation of miR-221-3p and miR-222-3p in the white adipose

35

tissues in C57BL/6 mice fed with high fat-high sucrose (HFHS) chow by RNA sequencing.

36

Mir221 and Mir222 are paralogous genes and share the common seed sequence and37

Mir221/222AdipoKO mice fed with HFHS chow demonstrated resistance to the38

development of obesity compared with Mir221/222flox/y. Ddit4 is a direct target of Mir221

39

and Mir222, and the upregulation of Ddit4 in Mir221/222AdipoKO was associated with the40

suppression of TSC2 (tuberous sclerosis complex 2)/mammalian target of rapamycin

41

complex 1 (mTORC1)/S6K (ribosomal protein S6 kinase) pathway. The inhibition of miR-

42

221-3p and miR-222-3p linked to reduced adipogenesis, and it may be a potential

43

candidate for miRNA-based therapy.

44
45

INTRODUCTION

46

In obesity, the excess and ectopic accumulation of adipose tissue leads to the clusters of47

metabolic disorders such as low-grade inflammation, type 2 diabetes (T2D), dyslipidemia,

48

hypertension, nonalcoholic fatty liver disorder (NAFLD), cardiovascular diseases (CVDs),

49

chronic kidney disease (CKD) and cancer. As an endocrine organ, the adipose tissue50

communicates with other tissues by secreting peptide hormones, inflammatory cytokines,

51

signaling lipids and miRNAs packed in exosomes (1). The alteration of expression profile of52

miRNA both in cytoplasm and extracellular vesicles leads to changes in the transcriptional53

and translational activities of the genes, which control inflammation, whole body insulin

54

sensitivity, lipid metabolism, adipogenesis of white, beige, and brown adipose tissues(2).

55

For instance, miR-34a secreted by mature adipocytes in exosomes were transported into

56

macrophages, suppresses M2 polarization, and stimulates inflammatory responses by57

repressing Krüppel-like factor 4(3). Lentivirus-mediated suppression of miR-34a increased2

58

the beige and brown fat formation in diet-induced obese mice by increasing fibroblast

59

growth factor 21 and sirtuin 1(4). The genetic ablation of miR-128-1 in mouse metabolic60

disease models resulted in increased energy expenditure, amelioration of diet-induced

61

obesity and enhanced insulin sensitivity(5). In lipid metabolism, miR-425 overexpression in62

mice resulted in the promotion of diet-induced obesity and overexpression of miR-425 in

63

3T3-L1 cells accelerated adipogenesis and lipogenesis, while knock down of miR-425

64

remarkably enhanced lipolysis and lipid oxidation(6).

65We also attempted to identify specific miRNAs critically involved in the process of66

obesity, we surveyed expression profile of miRNAs in liver, muscle, white adipose tissues

67(WATs), and sera of C57BL/6JJcl mice fed with standard (STD) and high fat-high sucrose

68(HFHS) chow by RNA sequencing (GSE61959)(7). miR-221-3p and miR-222-3p are highly69

up-regulated in epididymal adipose tissues in mice fed with high fat high sucrose (HFHS).

70

miR-221 and miR-222 both locate in the close proximity on the X chromosome and share71

the identical seed sequence(8). In meta-analysis, circulating miR-221-3p was reduced in

72

T2D, while miR-222-3p was elevated in obesity and T2D (9). Although miR-221-3p and73

miR-222-3p are differentially expressed in sera and adipose tissues, the functional in vivo

74

experiments to elucidate the roles of Mir221 and Mir222 in obesity has not been reported.

75

Here, we investigated the adipocyte specific Mir221 and Mir222 knockout

76(Mir221/222AdipoKO) mice fed with HFHS chow, and they were protected from the77

development of obesity by targeting DDIT4 (DNA damage inducible transcript 4)/TSC2

78(tuberous sclerosis complex 2)/S6K (ribosomal protein S6 kinase) pathway.

79
80

MATERIALS AND METHODS

81

Animal Models

82

We obtained Mir 221 KO cond (Mir221tm2; EMMA ID, EM:05507) from EMMA (the83European Mouse Mutant Archive) and Helmholz Zentrum München (Neuherberg,

84

Germany). The targeting vector cassette composed of Neo flanked by FRT and distal loxP3

85

sites was inserted outside the genomic region encoding Mir221 and Mir222 precursors.

86

Neo was removed by Flp in the conditional KO allele of Mir 221 KO cond. The conditional87

KO allele was confirmed by primer pair; 1544_29 (5’- GCT CTG TTT TCC TAA GTG ATG

88G-3’) and 1544_30 (5’-CTG ACA GGA AGT AAA TCA TCT TAG C-3’). The expected89

fragments were 265 bp in wild and 384 bp in conditional KO allele. We also used B6.FVB-

90

Tg (Adipoq-cre)1Evdr/J to produce Mir221/222AdipoKO mice by crossing to Mir 221 KO

91

cond. Adipoq-cre transgene was screened by primers, 15381 (5’-ACG GAC AGA AGC ATT92

TTC CA-3’) and 18564 (5’-GGA TGT GCC ATG TGA GTC TG-3’). The primers, oIMR7338

93(5’-CTA GGC CAC AGA ATT GAA AGA TCT-3’) and oIMR7339 (5’-GTA GGT GGA AAT

94

TCT AGC ATC ATC C-3’), were used for internal positive control. The expected sizes for95

transgene and internal positive control were 200 bp and 324 bp, respectively. By crossing

96

male Tg (Adipoq-cre) and female Mir221tm2/y C57BL/6JJcl mice, we generated male97

Mir221/222flox/y and male Mir221/222AdipoKO littermates.

98

Five-week-old mice were randomly assigned to standard diet (STD) group (MF, Oriental

99

Yeast, Japan) or high fat high sucrose diet (HFHS) group (D12331, Research Diets, New

100

Brunswick, NJ). The detailed formulation of STD(10) (https://www.oyc.co.jp/bio/LAD-

101

equipment/LAD/ingredient.html and https://www.oyc.co.jp/bio/LAD-

102

equipment/LAD/rodents.html) and HFHS

103

(https://www.eptrading.co.jp/service/researchdiets/pdf/D12328-D12331.pdf) diets are

104

shown in Supplementary Table 1. At 22 weeks of age, we obtained various organs and105

they were subjected to following experiments.

106
107

3T3-L1 Cell Cultures

108

3T3-L1 pre-adipocytes were cultured in Dulbecco's modified eagle's medium (DMEM,

109

2124951, Gibco). On day 0, the cells were treated with the differentiation media; DMEM

110

supplemented with 10% FBS, 10 µg/ml insulin (I1882, Sigma), 1 µM DEX (D2915, Sigma)111

and 0.5 mM IBMX (I5879, Sigma). Then, the media were changed to DMEM supplemented

4

112

with 10 µg/ml insulin and 10% FBS on day 2 and cultured for 10 or 20 days.

113

Undifferentiated 3T3-L1 cells were subjected to Lentiviral miRNA expression, Lentiviral

114

miRNA inhibition studies, and luciferase reporter assays.

115
116

Human Serum Samples

117

Human serum samples were collected from 69 patients with type 2 diabetes in Okayama

118

University Hospital and 45 subjects with normal fasting glucose (NGT).

119
120

Insulin Tolerance Test and Glucose Tolerance Test (ITT and GTT)121

The 13-week-old mice (n=4 in each experimental group) were fasted for 16 hours in GTT

122

and for 3 hours in ITT. They were then intraperitoneally injected with glucose solution

123(1 mg/g body weight) and human insulin (1 unit/kg in HFHS groups and 0.75 unit/kg in STD

124

groups) for GTT and ITT, respectively.

125
126

Basal Metabolic Rate, Locomotor Activity, and Food Intake

127

At 18 weeks of age, O2/CO2 metabolism measuring system (MK-5000, Muromachi Kikai,

128

Tokyo, Japan) were used to quantify oxygen consumption rate and carbon dioxide

129

production for the estimation of V̇O2 and respiratory quotient (RQ). The locomotor activity

130

was recorded for 24 hours by the frequency of interrupting an infrared sensor (ACTIMO-

131

100, Shinfactory, Fukuoka, Japan). Daily food intake was measured and calculated;

132

daily food intake [g/day/body weight (BW)] = [initial food weight (g) – leftover food weight133(g)]/measurement period (days)/BW (g). The 6-10 mice in each experimental group were134

examined.

135
136

Reverse Transcription-Quantitative Polymerase Chain Reaction (RT-qPCR)

137

RNAs were extracted from frozen tissues and cultured 3T3-L1 cells with RNeasy Mini kit

138(74106, Qiagen). The QIAamp Circulating Nucleic Acid Kit (Qiagen) were used for the

5

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isolation of total RNAs from serum. For gene expression analyses, cDNAs were prepared140

with High-Capacity RNA-to-cDNA Kit (Thermo Fisher Scientific). TaqMan gene expression

141

primers, Ddit4 (Mm00512504_g1), Rplp0 (Mm00725448_s1), Rn18s (Mm03928990_g1),

142

Adipoq (Mm00456425_m1), Lep (Mm00434759_m1), Lpl (Mm01345523_m1), Srebf1

143(Mm00550338_m1), Cebpa (Mm00514283_s1), Fabp4 (Mm00445878_m1), Pparg

144(Mm01184322_m1), Lipe (Mm00495359_m1), Pnpla2 (Mm00503040_m1), Ucp1

145

(Mm01244861_m1), Cox8b (Mm00432648_m1), Prdm16 (Mm00712556_m1), Cidea

146(Mm00432554_m1), Ppargc1a (Mm01208835_m1), G6pc (Mm00839363_m1), Gck

147(Mm00439129_m1), Fasn (Mm00662319_m1), Ppara (Mm00440939_m1), Il6148(Mm00446190_m1), Ifng (Mm01168134_m1), Tnf (Mm00443258_m1), Il1b149

(Mm01336189_m1) were used (Thermo Fisher Scientific). For miRNA expression studies,

150

cDNAs were prepared from total RNAs by TaqMan MicroRNA Reverse Transcription Kit

151(Life Technologies). MicroRNA primers, mmu-miR-222-3p (CTAAJ3), hsa-miR-221-3p

152(000524), hsa-miR-222-3p (002276), snoRNA202 (001232), snoRNA234 (001234), and153

cel-miR-39 (000200) were used (Thermo Fisher Scientific). Rplp0, Rn18s, snoRNA202,

154

snoRNA234, and cel-miR-39 were served as the invariant controls. The RT-qPCR was

155

performed using TaqMan Universal PCR Master mix II (no UNG) at a StepOne Plus Real-156

Time PCR system. The quantification was performed by the 2−ΔΔCT analysis method.

157
158

Cloning of Mir221 Host Gene (Mir221hg)

159

Long non-coding RNA, Mir221hg, was cloned using SMARTer RACE 5’/3’ Kit (634858,

160

Clontech). 5’- and 3’-RACE-Ready cDNAs from epididymal adipose tissues poly A+ RNA161

were prepared by SMARTScribe Reverse Transcriptase. 5’- and 3’-RACE-Ready cDNAs

162

were amplified by PCR using 5’ GSP (5’-GAT TAC GCC AAG CTT CCA GCA GAC AAT

163

GTA GC TGT TGC-3’) and 3’ GSP (5’-GAT TAC GCC AAG CTT TCC AGG TCT GGG GCA164

TGA ACC TG-3’), respectively. Furthermore, nested PCR was performed using 5’ NGSP

165

(5’-GAT TAC GCC AAG CTT GTA TGC CAG GTT CAT GCC CCA GAC-3’) and 3’ NGSP

6

166

(5’-GAT TAC GCC AAG CTT GCA ACA GCT ACA TTG TCT GCT GG-3’). PCR products

167

were analyzed by agarose/EtBr gel and purified by NucleoSpin Gel and PCR Clean-Up Kit.

168

The purified RACE products were subcloned into pRACE vector by In-Fusion Cloning

169(Clontech). Independent 4 clones of both 5’- and 3’-RACE were sequenced.

170
171

Western Blot Analysis

172

The epididymal fat tissues from 22-week-old mice and cultured 3T3-L1 cells were173

homogenized in RIPA lysis buffer (radioimmunoprecipitation buffer) plus protease inhibitors.

174

The samples were boiled in SDS-PAGE loading buffer, separated on 12% Mini-PROTEAN175

TGX Precast Protein Gels (Bio-Rad), and transferred to a PVDF Blotting Membrane176(cytiva). After blocking with 5% nonfat milk for 1 hour at room temperature (RT), the blots

177

were incubated with REDD-1/DDIT4 Antibody, rabbit polyclonal (ab106356, RRID:

178

AB_10864294), C/EBPα Antibody, rabbit polyclonal (2295, RRID: AB_10692506), PPARγ

179(D69) Antibody, rabbit polyclonal (2430, RRID: AB_823599), mTOR (7C10) Rabbit mAb

180(2983, RRID: AB_2105622), Phospho-mTOR (Ser2448) (D9C2) XP Rabbit mAb (5536,

181

RRID: AB_10691552), Akt Antibody, rabbit polyclonal (9272, RRID: AB_329827), Phospho-

182

Akt (Thr308) Antibody, rabbit polyclonal (9275, RRID: AB_329828), p70 S6 Kinase (49D7)

183

Rabbit mAb (2708, RRID: AB_390722), Phospho-p70 S6 Kinase (Thr389) Antibody, rabbit

184

polyclonal (9205, RRID: AB_330944), Tuberin/TSC2 Antibody, rabbit polyclonal (3612,

185

RRID: AB_2207804), Phospho-Tuberin/TSC2 (Thr1462) Antibody, rabbit polyclonal (3611,

186

RRID: AB_329855, Cell Signaling Technology) overnight at 4°C. GAPDH (D16H11) XP

187

Rabbit mAb (HRP Conjugate) (8884, RRID: AB_11129865) was used as a loading control

188(Cell Signaling Technology). After washing three times with Tris-buffered saline (TBS), the189

blots were incubated with ECL Donkey Anti-Rabbit IgG, HRP-Conjugated Antibodies

190(NA934V, GE healthcare Life science, 1:10000) at RT for 1 hour. The blots were developed

191

with Pierce ECL Western Blotting Substrate (TE261327, Thermo Fisher Scientific). The

192

chemiluminescence was analyzed using ImageQuant LAS-4000 mini (FUJIFILM).

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194

Morphometric Analysis for Adipocyte Size

195

Epidydimal adipose tissues were fixed by 10% formalin, embedded with paraffin. The 5-μm

196

paraffin sections were prepared and stained with PAS. The images were captured using an

197

Olympus BX51 microscope. The size of the adipocytes was analyzed by Keyence Hybrid

198

cell count software. Epidydimal adipose tissues were taken from 3-5 individual animals

199

from each experimental group.

200
201

Isolation of Stromal Vascular Fraction (SVF) from White Adipose Tissues

202

SVF was isolated from epididymal adipose tissue of 24-week-old mice. Briefly, fresh mouse203

epididymal fat pads were minced and digested with collagenase type 1 (CLSS1,

204

Worthington) in HBSS containing 10% FBS for 45 minutes at 37°C. The mixture was

205

filtered through a nylon mesh (100 μm), then centrifuged at 400 g for 1 minute. The

206

adipocyte fraction was obtained from the supernatant, they were again centrifuged at 800 g

207

for 10 minutes, and the SVF was obtained from the pellet.

208
209

Identification of Mir221/222 Target mRNAs

210

The mRNA microarray was performed by GeneChip Mouse Gene 2.0 array using total RNA

211

of epidydimal fat obtained from 16-week-old mice (1 animal from each group) and analyzed

212

by Filgen (Nagoya, Japan). The raw data are available in Gene Expression Omnibus (GEO;213

https://www.ncbi.nlm.nih.gov/geo/) (GSE163921). TargetScan

214(http://www.targetscan.org/vert_72/), miRDB (http://www.mirdb.org/), Pictar

215(https://pictar.mdc-berlin.de/) and DIANA-microT v5.0 (https://bio.tools/DIANA-microT) and216

were used to identify potential target genes for Mir221/222.

217
218

Lentiviral miRNA Expression and Lentiviral miRNA Inhibitor

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Lentiviral transduction using pLV-miRNA and pLV-miR-Locker system to 3T3-L1 cells were220

performed according to the manufacturer’s manual (Biosettia). After transformation to E.

221coli JM109 cells, pLV-[mmu-mir-221] plasmid (mir-p177m, Biosettia), pLV-[mmu-mir-222]

222

plasmid (mir-p178m, Biosettia), pLV-[mmu-mir-221-3p] locker plasmid (mir-mp0337,

223

Biosettia), pLV-[mmu-mir-222-3p] locker plasmid (mir-mp0339, Biosettia), pLV-[mir-control]

224

plasmid (mir-p000, Biosettia), pLV-miR-locker control plasmid (mir-locker-ctrl, Biosettia),

225

pMDLg/pRRE (12251, Addgene), pRSV/Rev (12253, Addgene), and pMD2.G (12259,

226

Addgene) were isolated with EndoFree Plasmid Maxi Kit (12362, Qiagen). 293T cells (10 ×227

107/5 mL) were transfected with each pLV plasmid, pMDLg/pRRE, pRSV/Rev, pMD2.G,

228

Lipofectamine LTX, and 1.5 mL Opti-MEM. The supernatants were collected after 48 hours

229

after transfection. 3T3-L1 cells were transduced with lentivirus stock in complete media

230

containing 10 μg/mL polybrene for 12 hours, replaced with fresh complete medium

231
232

Luciferase Reporter Assay233

To quantitatively evaluate miRNA activity on cloned miRNA target sequence from 3’-

234

untranslated region (3’-UTR) of Ddit4, pmirGLO dual luciferase miRNA Target expression

235

vector (E1330, Promega) was used. Firstly, the pmirGLO plasmid was linearized by double

236

digestion with XhoI and SalI. The cDNA of Ddit4 wild type (WT) 3′-UTR was amplified by237

PCR and ligated with CIP treated pmirGLO Vector. The primers are Forward-XhoI-3’UTR-

238

Ddit4: 5’-GGG GGG CTC GAG CAG CTG CTC ATT GAA GAG TG-3′, and Reverse-SalI-

239

3’UTR-Ddit4: 5’-GGG GGG GTCGAC CAA ACC AAC AGA GGA GAC AG-3′. pmirGLO-

240

Ddit4 MT 3’-UTR was prepared by site directed mutagenesis by PCR using primers;

241

Forward-MT-Seed-Ddit4: 5’-CTG GAT GTG TAT CTG CAT GTA C-3’ and Reverse-MT-

242

Seed-Ddit4: 5’-GTA CAT GCA GAT ACA CAT CCA G-3’. The seed sequence “CGATGTA”

243

was mutated to “CGTCTA”. After transformation to E. coli JM109 cells, pmirGLO-Ddit4 WT

244

3’-UTR, pmirGLO-Ddit4 MT 3’-UTR, and pmirGLO no-insert control plasmids were isolated245with EndoFree Plasmid Maxi Kit (12362, Qiagen). 3T3-L1 cells were seeded at a density of

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120,000 cells/mL, then co-transfected with Syn-mmu-miR-221-3p (MIMAT0000669,

247

Qiagen), Syn-mmu-miR-222-3p (MIMAT0000670, Qiagen), negative control siRNA

248(1027280, Qiagen), inhibitor negative control (1027271, Qiagen), pmirGLO-Ddit4 WT 3’-

249

UTR, pmirGLO-Ddit4 MT 3’-UTR, and pmirGLO no-insert control plasmids. Twenty-four

250

hours after transfection, the cells were analyzed to measure luciferase activities using the251

Dual-Glo Luciferase Assay System and a GloMax 20/20 luminometer (Promega).

252
253

Statistical Analysis

254

All values were represented as the mean ± standard deviation (SD). Statistical analyses

255

were conducted using IBM SPSS Statistics 23 and GraphPad Prism (version 8.0).

256

Independent t-test, Mann-Whitney's U test, and one-way ANOVA with Tukey test was used257

to determine the differences. For correlation, non-parametric Spearman r coefficient was258

used. p<0.05 was considered statistically significant.

259
260

RESULTS

261

Mir221/222AdipoKO mice are resistant to diet-induced obesity262

To identify miRNAs critically involved in the disease process of obesity and type 2 diabetes

263(T2D), we performed miRNA profiling of serum, liver and epididymal fat tissues in

264

C57BL/6JJcl mice fed with standard (STD) and high fat-high sucrose (HFHS) chow. The

265

Illumina RNA sequencing data (Gene Expression Omnibus number GSE61959)

266

demonstrated that the read numbers of Mir221 and Mir222 were 5.7 and 8.2-fold up-

267

regulated in epididymal adipose tissues in HFHS group compared with STD group268(Supplementary Table 2). Mir221 and Mir222 are paralog genes located in proximity on X

269

chromosome and they share identical seed sequence. To further investigate the role of270

Mir221/222 in obesity and diabetes, we crossed male Tg (Adipoq-cre) mice and female271

Mir221tm2/y C57BL/6JJcl mice and generated male Mir221/222flox/y and male272

Mir221/222AdipoKO littermates.

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Body weight of Mir221/222AdipoKO mice fed with HFHS chow was significantly reduced

274

compared with Mir221/222flox/y mice (Figure 1A). The weight of epididymal, mesenteric,275

subdermal, and brown fat was also reduced in Mir221/222AdipoKO mice (Figure 1B). The

276

Mir221/222flox/y and Mir221/222AdipoKO mice fed with STD chow demonstrated no277

significant differences in their body and tissue weight (Figure 1A and 1B). The average

278

size of adipocytes in epididymal adipose tissues derived from Mir221/222AdipoKO mice fed

279with HFHS chow was smaller compared with Mir221/222flox/y mice (Figure 1C). To

280

investigate glucose homeostasis, we performed insulin tolerance test (ITT) and glucose

281

tolerance test (GTT). The blood glucose levels of Mir221/222AdipoKO mice fed with HFHS

282

chow were reduced in GTT and ITT compared with Mir221/222flox/y, but they did not reach283

significant differences (Figure 1D). The serum insulin concentrations of284

Mir221/222AdipoKO mice were significantly lower than Mir221/222flox/y, suggesting the285

improvement of insulin sensitivity in Mir221/222AdipoKO mice (Figure 1D). To investigate

286

whether reduced adiposity in Mir221/222AdipoKO mice was due to changes in energy

287

expenditure or energy intake, we measured basal metabolic rates, locomotor activity and288

food intake. Basal metabolic rate such as respiratory quotient and oxygen consumption289

were not altered between Mir221/222flox/y and Mir221/222AdipoKO mice fed with HFHS

290

chow (Supplementary Figure 1A and 1B). The locomotor activity was recorded for 24

291

hours, most of the activities were observed during the dark phase. Increased activity was292

observed in Mir221/222AdipoKO mice under HFHS chow compared with Mir221/222flox/y293

during light (0.944 ± 0.309 vs 1.60 ± 0.764 counts/min, p=0.036) and dark (6.67 ± 4.38 vs

294

7.94 ± 4.38 counts/min, p=0.497) periods (Supplementary Figure 1C). Food consumption

295

were not altered in Mir221/222AdipoKO and Mir221/222flox/y fed with HFHS

296

(Supplementary Figure 1D). Under HFHS chow, serum leptin concentrations were297

significantly reduced in Mir221/222AdipoKO compared with Mir221/222flox/y (24.5 ± 2.35 vs298

21.5 ± 1.85 ng/ml, p=0.043), while serum adiponectin concentrations were not altered

299(Supplementary Figure 1E and 1F). In quantitative RT-PCR in epididymal adipose

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300

tissues, mRNA expression of Lep was significantly reduced in Mir221/222AdipoKO. The

301

genes related to adipogenesis, such as Pparg, Cebpa, Ppargc1 and Prdm16, were not302

altered in Mir221/222AdipoKO (Supplementary Figure 2).

303
304

Expression Mir221 and Mir222 are highly induced by HFHS chow feeding in mature305

adipocytes from epidydimal adipose tissue306

We investigated the expression of Mir221 and Mir222 in various organs. Both miR-221-3p

307

and miR-222-3p were abundantly expressed in brain, kidney, and lung in Mir221/222flox/y308

and they were down-regulated or not altered by the HFHS feeding compared with STD

309

chow. In contrast, both miR-221-3p and miR-222-3p were significantly upregulated in the310

epidydimal fat tissues, and such upregulation was canceled in the epidydimal fat tissues of311

Mir221/222AdipoKO fed with HFHS chow (Figure 2A and 2B). Next, we investigated the312

localization of Mir221 and Mir222 in the cell fractions of epididymal adipose tissues. Both313

miR-221-3p and miR-222-3p were significantly induced by HFHS chow in mature314

adipocytes of Mir221/222flox/y, while the upregulation was significantly reversed in the315

mature adipocyte of Mir221/222AdipoKO fed with HFHS chow. In contrast, miR-221-3p and316

miR-222-3p were not significantly upregulated in the stromal vascular fraction (SVF) from317

Mir221/222flox/y fed with HFHS chow (Figure 2C). We also assessed the expression of miR-

318

221-3p and miR-222-3p during 3T3-L1 adipocyte differentiation. Both miR-221-3p and miR-

319

222-3p continuously down-regulated after the induction of adipocyte differentiation

320(Supplementary Figure 3A). Finally, we assessed the serum concentrations of mmu-miR-

321

221-3p and mmu-miR-222-3p by quantitative PCR and they were not altered in322

Mir221/222flox/y and Mir221/222AdipoKO fed with STD and HFHS chow, suggesting serum323

mature forms of Mir221 and Mir222 were derived from various organs but not exclusively

324

from adipose tissues (Supplementary Figure 4A). In human samples from the subjects

325with normal glucose tolerance (NGT, n=45) and impaired glucose tolerance (IGT, n=69),326

hsa-miR-221-3p and hsa-miR-222-3p demonstrated negative (R2=0.1311, p<0.0001) and

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327

positive correlations (R2=0.03841, p=0.0441) with HbA1c levels, respectively

328(Supplementary Figure 4B and 4C).

329
330

Identification of Mir221hg and its expression

331

The miRNA genes are classified as intergenic and intragenic miRNAs, and the intragenic

332

miRNAs and related host genes share the common transcriptional regulation. The long333

non-coding RNA (lncRNA), namely mir-221 host gene (MIR221HG), has been reported in

334

bovine, which inhibits the adipocyte differentiation in cultured cells(11). Thus, we performed

335

5’ and 3’ rapid amplification of cDNA ends (5’/3’RACE) using poly A+ RNA purified from336

epidydimal fat tissues of C57BL/6JJcl mice and cloned 1537 bp single exon lncRNA

337(Mir221hg, MW581002) which overlap Mir221 (Supplementary Figure 5A). Next, we

338

designed primers for quantitative PCR of Mir221hg and evaluated gene expression in339

various tissue. Mir221hg was abundantly expressed in brain in Mir221/222flox/y and they340

were upregulated in brain, heart, liver, intestine, spleen by the HFHS feeding compared341

with STD chow. The expression of Mir221hg was rather low in various adipose tissues and342

its lncRNA expression was not changed in Mir221/222AdipoKO fed with STD and HFHS

343

chow (Supplementary Figure 5B and 5C). Although Mir221hg lncRNA may be functional344

as a reservoir for miR-221-3p, the role of Mir221hg lncRNA in adipose tissues was limited

345

in our experiments.

346
347

miR-221-3p and miR-222-3p target Ddit4

348

To investigate the mechanism for the resistance to diet-induced obesity in349

Mir221/222AdipoKO, we attempted to identify the potential target genes for miR-221-3p

350

and miR-222-3p. We performed mRNA profiling by GeneChip Mouse Gene 2.0 array using

351

total RNA purified from epidydimal fat tissues of Mir221/222flox/y fed with STD or HFHS,

352

Mir221/222AdipoKO fed with STD or HFHS chow (Supplementary Table 3, 4 and 5).

353

Then, we made the list of 355 target genes commonly predicted by TargetScan, miRDB,

13

354

and DIANA-microT, and their seed sequences were conserved in both human and mouse355

genome (Supplementary Table 6). By searching upregulated genes in356

Mir221/222AdipoKO compared with Mir221/222flox/y in both STD and HFHS fed groups, we

357

identified that DNA-damage-inducible transcript 4 (Ddit4) demonstrated 1.9-fold and 2.58-

358

fold upregulation in Mir221/222AdipoKO fed with HFHS and STD chow, respectively

359(Supplementary Table 7). To evaluate miRNA activity of miR-221-3p and miR-222-3p by360

the binding to 3’-untranslated region (3’-UTR) of Ddit4, we performed luciferase reporter

361

assay in 3T3-L1 cells. We cloned 3’-UTR regions of Ddit4 gene and prepared the wild-type362

reporter vector, pmirGLO-Ddit4 WT 3’-UTR, and the mutant vector, pmirGLO-Ddit4 MT 3’-

363

UTR, in which mutagenesis was induced on the seed sequence binding site (Figure 3A).

364

The luciferase reporter vectors were co-transfected with Syn-mmu-miR-221-3p or Syn-365

mmu-miR-222-3p or negative control siRNA in 3T3-L1 cells. As a result, reporter activity of366

pmirGLO-Ddit4 WT 3’-UTR were significantly inhibited in the presence of both Syn-mmu-

367

miR-221-3p and Syn-mmu-miR-222-3p. In contrast, Syn-mmu-miR-221-3p or Syn-mmu-

368

miR-222-3p had almost no effect on the reporter activity of pmirGLO-Ddit4 MT 3’-UTR

369(Figure 3A). Next, we checked the expression of Ddit4 in the epidydimal adipose tissues of370

Mir221/222flox/y and Mir221/222AdipoKO fed with HFHS by quantitative PCR and Western371

blot. Although the mRNA expression of Ddit4 was increased in Mir221/222AdipoKO without

372

statistical significance, DDIT4 protein expression was significantly upregulated in the373

Mir221/222AdipoKO compared with Mir221/222flox/y (Figure 3B), suggesting the possible

374

involvement of translational repression by miR-221-3p and miR-222-3p.

375
376

miR-221/222 promotes adipogenesis by DDIT4-mediated inhibition of mTORC1

377

DDIT4 is known to activate tuberous sclerosis complex 1 (TSC1)/TSC2 complex by the378

inhibition of AKT (protein kinase B) and the release of 14-3-3 from TSC2(12). It further

379

negatively regulates mammalian target of rapamycin complex 1 (mTORC1) (13). Increased380

activity of the mTORC1 signaling has been associated with obesity(14), and the knockout

14

381

mice for the mTORC1 downstream ribosomal protein S6 kinase (S6K) are protected382

against diet-induced-obesity(15). Thus, we further checked the inactivated form of p-TSC2

383(Thr-1462) and activated form of p-S6K(16) in the epidydimal adipose tissues of384

Mir221/222flox/y and Mir221/222AdipoKO. After overnight fasting, the mice were injected385

intraperitoneally with insulin and the epidydimal fat tissues were harvested at 7 min after

386

insulin injection. In Mir221/222AdipoKO mice, both p-AKT and p-TSC2 (Thr-1462) were387

significantly reduced, and accordingly p-S6K was also significantly reduced (Figure 4A and

388

4B). p-mTOR was reduced in Mir221/222AdipoKO mice, however, it did not reach the389

statistically significant differences (Figure 4A and 4B).

390

Since mTOR has been shown to positively regulate adipogenesis and lipogenesis while391

inhibiting lipolysis, fatty acid oxidation and ketogenesis(17), we performed adipogenesis392

and glycerol assays in 3T3-L1 adipocytes. We constructed lentiviral vector expressing

393

miRNA inhibitors (pLV-locker 221, pLV-locker 222, pLV-locker control) and miRNA mimics

394(pLV 221, pLV 222, pLV control). The efficiency for inhibitors and mimics was confirmed in

395

3T3-L1 cells at 3-7 days after the transduction (Supplementary Figure 3B and 3C).

396

Lentiviral vectors were transduced to 3T3-L1 cells at 2 days before the induction of397

differentiation and cultured for 7 days. The pLV-locker 221, pLV-locker 222, and pLV-locker

398

221/222 did not alter the accumulation of lipid droplets demonstrated by oil red O staining399

measured by absorbance at 490 nm (Figure 5A). Similarly, pLV 221, pLV 222, and400

pLV221/222 only show slight increase in the accumulation of lipid droplets in 3T3-L1 cells

401

without statistical significance (Figure 5B). Western blot analysis demonstrated that the402

expression of C/EBPα and PPARγ were not changed by pLV-locker 221 and pLV-locker

403

222 (Figure 5C), while they were significantly up-regulated by treatment with pLV 221 and404

pLV 222 (Figure 5D). To investigate lipolysis, lentiviral vectors were transduced to the fully

405

differentiated 3T3-L1 adipocyte and we performed glycerol assay 7 days after lentiviral406

transduction. pLV-locker 221/222 and pLV 221/222 did not alter the glycerol release

407(Figure 5E).

15

408
409

DISCUSSION410

The adipocyte-specific inhibition of Mir221/Mir222 expression protected the mice fed with

411

HFHS chow from the obesity. We demonstrated that the direct target of miR-221-3p and412

miR-222-3p was Ddit4 and the inhibition of Mir221/Mir222 expression resulted in

413

upregulation of DDIT4, inactivation of AKT, activation of TSC2 and subsequent inactivation414

of S6K, the latter is a major target of mTORC1. The lentivirus-mediated transfer of Mir222

415

gene promoted the adipogenesis demonstrated by up-regulation of C/EBPα and PPARγ in

416

differentiated 3T3-L1 cells. We concluded that the inhibition of miR-221-3p and miR-222-3p

417

and DDIT4-mediated inhibition of mTORC1 signaling is one of the major mechanisms for418

the protection from diet-induced obesity. The role of Mir221 in adipogenesis has been419

focused by series of investigation and Ahonen et al. reported miR-221-3p overexpression in420

Simpson-Golabi-Behmel syndrome (SGBS) preadipocytes inhibited de novo lipogenesis421

and adipogenesis(18). In our investigation, overexpression by pLV 221 did not alter the422

lipogenesis and adipogenesis in 3T3-L1 cells; however, pLV 222 enhanced the423

adipogenesis. In bovine adipocyte differentiation, long non-coding RNA (lncRNA),424

MIR221HG, significantly increased adipocyte differentiation associated with dramatic

425

increment of PPARγ(11). We also cloned mouse Mir221hg with 1,537 bp and identified that426

1,054 bp of 5’-flanking region was deleted in Mir221/222AdipoKO mice. The expression of427

Mir221hg is barely detected in brown and WATs in wild type mice and we speculated that428

the influence of deletion of Mir221hg is minimal in Mir221/222AdipoKO mice. Although the429functional studies to elucidate the role of Mir222 in adipogenesis and lipogenesis were not430reported in cultured adipocytes in previously published studies, we demonstrated that431

Mir222 expression was upregulated in WATs and serum in both obese patients. The

432

importance of Mir222 in the pathogenesis of obesity is supported by the analysis of adipose

433

tissue-specific Dicer knockout mice, in which gonadal adipose tissue was the main source434

of serum exosomal miR-222(19). The exosome-packed Mir222 influenced remote organs,

16

435

and overexpression of Mir222 inhibits the expression of IRS-1 by directly binding to436

untranslated regions in the muscle(20) and liver(21). In current investigation, we firstly

437

demonstrated that overexpression of Mir222 enhanced mTORC1 pathway and promoted438

the adipogenesis in 3T3-L1 cells.

439

Under the presence of amino acids, mTORC1 is activated by GTP-bound Rheb. In the440

upstream of the Rheb, AKT inhibits TSC2 and TBC1D7 (TBC1 Domain Family Member 7)

441

complex, which further inhibits the activation of mTORC1 by acting as a GTPase-activating442

protein. mTORC1 promotes the lipid synthesis and storage and adipogenesis, while it443

inhibits the lipolysis, β-oxidation and ketogenesis. SREBP (sterol regulatory element-444

binding protein) processing and activation is promoted by mTORC1 by the activation of445

S6K and lipin 1 leading to transcriptional activation of SREPB1, SREBP2, and many other446

lipogenic genes. mTORC1 also committed mesenchymal stem cells to adipocyte lineage by447

the activation of S6K, promotes the initial step of adipocyte differentiation by inhibiting 4E-

448

BP1/2 (eIF4E-binding protein 1/2), and completes the final differentiation by the activation

449

of PPARγ(22). Many researchers screened the agents or intrinsic factors to inhibit

450mTORC1 signaling and lipogenesis for the treatment of obesity. Lee et al. reported that451

ezetimibe reduced lipid accumulation by inhibiting mTORC1 signaling, leading to the452

downregulation of lipogenesis-related genes(23). Shi et al. reported that the inhibition of453

miR-196b-5p blocked adipogenesis and lipogenesis by directly targeting TSC1 and454

TGFBR1 (transforming growth factor-β receptor 1)(24). We demonstrated that the inhibition455

of miR-221-3p and miR-222-3p and subsequent DDIT4-mediated inhibition of mTORC1

456

signaling is a therapeutic target for the treatment of obesity.

457

The activation of mTORC1 links to various pathological processes in adipose tissues

458

such as inflammation, beige adipogenesis and angiogenesis. mTORC1 loss and gain of459

function studies in macrophages resulted in amelioration and exacerbation of inflammatory

460

response, as well as macrophage polarization to both M1 and M2 profiles(25). miR-221

461

mediates M1 macrophage polarization(26, 27), while suppression of miR-222 alleviate the

17

462

inflammatory response(28, 29). However, we did not observe the apparent changes in463

gene expression of cytokines such as Il1b, Il6, Ifng, and Tnf in adipose tissues in464

Mir221/222AdipoKO mice (Supplementary Figure 2). The phenotyping of T cells and465

macrophages in WATs should be performed in the future investigation. In beige

466

adipogenesis, the adipose-specific deletion of Raptor, a key component of mTORC1,

467

promoted beige adipogenesis by inhibiting prostaglandins (PGs) synthesized by468

cyclooxygenase-2 (COX-2)(30). Supporting this notion, ketoprofen alleviated diet-induced

469

obesity and promotes the fat browning by the COX-2 and mTORC1-p38 signaling

470

pathway(31). In our investigation, the genes related to beige adipogenesis such as Ppargc1

471

and Prdm16 tended to be upregulated in WATs without statistical differences. However, in

472

WATs in Mir221/222AdipoKO mice, apparent beige adipogenesis was not observed by473

histological examinations. In tumor microenvironment and angiogenesis, mTORC1 under a474

hypoxic condition promotes the translation of hypoxia-inducible factor (HIF) 1-2, which lead475

to the expression of angiogenic growth factors such as vascular endothelial growth factor

476(VEGF), TGF-α, and platelet-derived growth factor β (PDGF-β)(32). Mir221 and Mir222

477

demonstrated the angiogenic activities in vascular cells(33) and cancers(34), however, we478

did not observe the angiogenesis activities in WATs in Mir221/222AdipoKO mice.

479
480

Limitation of Study

481

We hypothesized that circulating miR-221-3p and miR-222-3p play important roles in both482

mouse obese models and the patients with obesity and T2D. However, the circulating483

levels of miR-221-3p and miR-222-3p were not altered in Mir221/222flox/y and484

Mir221/222AdipoKO mice fed with STD and HFHS. In addition, the human serum levels of485

miR-221-3p and miR-222-3p showed correlations with HbA1c, however, they did not show486

significant correlations with body weight and BMI. Although we show the roles of miR-221-487

3p and miR-222-3p in the adipocytes, we did not clearly demonstrate the role of circulating488

miR-221-3p and miR-222-3p in the pathogenesis of obesity. Another limitation is that it is

18

489

still unknown why Mir221/222AdipoKO mice did not show significant improvement of insulin

490

sensitivity although the body weight was significantly reduced compared with

491

Mir221/222flox/y fed with HFHS. Finally, the micronutrient composition is not matched

492

between the STD and HFHS diets and it may possibly impact the observed outcomes.

493

Ideally, a matched diet should be used for mineral and vitamin mix.

494
495

DATA AVAILABILITY

496

RNA sequencing and mRNA microarray data generated in this study is available at GEO:

497

GSE61959 and GSE163921.

498
499

ETHICS STATEMENT

500

All animal experiments were approved by the Animal Care and Use Committee of the501

Department of Animal Resources, Advanced Science Research Center, Okayama

502

University (OKU-2015547, 2016201, 2016202, 2018479, 2018480, and 2018481). The

503

observational clinical study was approved by Okayama University Graduate School of504

Medicine, Dentistry and Pharmaceutical Sciences and Okayama University Hospital, Ethics

505

Committee (#1708-045).

506
507

CONFLICT OF INTEREST

508

Jun Wada receives speaker honoraria from Astra Zeneca, Daiichi Sankyo, Novartis, Novo

509

Nordisk Pharma, Tanabe Mitsubishi and receives grant support from Astellas, Baxter,

510

Bayer, Chugai, Dainippon Sumitomo, Kyowa Kirin, Novo Nordisk Pharma, Ono, Otsuka,

511

Tanabe Mitsubishi, and Teijin.

512
513

Author contributions

514

SY, DZ, AK, and JW designed the project and experiments and wrote the manuscript. SY,

515

DZ, AK, NK, RS, and HHHA performed animal experiments and analyzed and interpreted

19

516

data. AN and JE performed culture and molecular biology experiments. SY, AK, NK, RS,

517

AN, JE, and JW designed and performed clinical study.

518
519

FUNDING

520

This work was supported by Grant-in-Aid for Young Scientists (19K17984), Grant-in-Aid for

521

Scientific Research (B) (19H03675), Japan Agency for Medical Research and development

522(AMED, grant no: 17ek0210095h0001, 20ek0109445h0001).

523
524

ACKNOWLEDGEMENTS

525

We acknowledge support from Central Research Laboratory, Okayama University Medical

526

School; usage of BECKMAN COULTER XL 80, ABI PRISM3130, and producing paraffin

527

blocks and sections.

528
529

SUPPLEMENTARY MATERIAL

530

The supplementary Material for this article can be found online.

531
532

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533
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FIGURE LEGENDS

648

Figure 1. The metabolic phenotypes of Mir221/222flox/y and Mir221/222AdipoKO male mice649

fed with high fat high sucrose (HFHS) or standard (STD) chow. (A) Body weight of650

Mir221/222flox/y and Mir221/222AdipoKO mice fed with HFHS (n=7) or STD chow (n=6),651

respectively. (B) Tissue weight of Mir221/222flox/y and Mir221/222AdipoKO mice fed with

652

HFHS or STD chow at 24 weeks of age. (Epi, epididymal; Mes, mesenteric; Sub, inguinal;

653

Brown, Brown adipose tissues) (C) Adipocyte area in epididymal adipose tissues of654

Mir221/222flox/y (n=3) and Mir221/222AdipoKO (n=5) mice fed with HFHS or STD.

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Conciatori F, Bazzichetto C, Falcone I, Pilotto S, Bria E, Cognetti F, et al. Role of mTOR
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Poliseno L, Tuccoli A, Mariani L, Evangelista M, Citti L, Woods K, et al. MicroRNAs
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Xu CH, Liu Y, Xiao LM, Chen LK, Zheng SY, Zeng EM, et al. Silencing microRNA221/222 cluster suppresses glioblastoma angiogenesis by suppressor of cytokine
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10.1002/jcp.28794

23

655

Quantitative analyses were carried out on PAS-stained paraffin sections. (D) Insulin

656

tolerance test (ITT) and glucose tolerance test (GTT) in mice fed with HFHS (n=7) or STD

657

chow (n=6). Data shown as mean ± SD and analyzed by one-way ANOVA with Tukey test

658

in A and B, and Mann-Whitney's U test in C and D (*p<0.05; **p<0.01; ***p<0.001;

659****p<0.0001).

660

Figure 2. Expression of Mir221 and Mir222 in Mir221/222flox/y and Mir221/222AdipoKO661

male mice fed with high fat high sucrose (HFHS) or standard (STD) chow. (A and B) In

662

various tissues, the expression of miR-221-3p and miR-222-3p is normalized by663

snoRNA202 and snoRNA234. The HFHS-induced up-regulation of miR-221-3p and miR-

664

222-3p in epididymal adipose tissues was reversed in Mir221/222AdipoKO (red asterisks).

665(Epi, epididymal; Mes, mesenteric; Sub, inguinal; Brown, Brown adipose tissues) (C)666

Serum concentration of miR-221-3p and miR-222-3p. HFHS Mir221/222flox/y (n=3), HFHS

667

Mir221/222AdipoKO (n=5), STD Mir221/222flox/y (n=5) and STD Mir221/222AdipoKO mice

668(n=6). Data shown as mean ± SD and analyzed by one-way ANOVA with Tukey test669(*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001).

670

Figure 3. Dual-luciferase reporter assay for Ddit4 3’UTR and expression of Ddit4 in mice.

671(A) Dual-luciferase reporter assay using pmirGLO-Ddit4 WT 3’-UTR, pmirGLO-Ddit4 MT 3’-

672

UTR, and pmirGLO no-insert control plasmids. 3T3-L1 cells were co-transfected with Syn-673

mmu-miR-221-3p (n=4), Syn-mmu-miR-222-3p (n=4), negative control siRNA (n=8). (B)674

Quantitative RT-PCR for Ddit4 in epididymal adipose tissues of Mir221/222flox/y (n=4) and675

Mir221/222AdipoKO (n=8) mice fed with high fat high sucrose (HFHS). Western blot

676

analyses for DDIT4 and GAPDH (glyceraldehyde-3-phosphate dehydrogenase) in

677

epididymal adipose tissues of Mir221/222flox/y (n=3) and Mir221/222AdipoKO (n=7) mice fed

678with high fat high sucrose (HFHS). Data shown as mean ± SD and analyzed by Mann-

679

Whitney's U test (*p<0.05; **p<0.01).

24

680

Figure 4. Western blot analyses. (A) Western blot analyses for AKT (protein kinase B),

681

TSC2 (tuberous sclerosis complex 2), mTOR (mammalian target of rapamycin) and S6K

682(ribosomal protein S6 kinase) in Mir221/222flox/y (n=3) and in epididymal adipose tissues of683

Mir221/222AdipoKO (n=5) male mice fed with high fat high sucrose (HFHS). Activated form684

of p-AKT and Inactivated form of p-TSC2 (Thr-1462) and activated form of p-S6K are

685

shown. (B) Densitometric analyses of Western blots. Data shown as mean ± SD and

686

analyzed by Mann-Whitney's U test (*p<0.05).

687

Figure 5. Adipogenesis, lipogenesis and lipolysis in 3T3-L1 cells. Lentiviral vectors were688

transduced to 3T3-L1 cells at 2 days before the induction of differentiation and cultured for689

7 days. (A) Oil-red O staining of differentiated 3T3-L1 cells treated with pLV-locker control,690

pLV-locker 221, pLV-locker 222, and pLV-locker 221/222. (B) Oil-red O staining of

691

differentiated 3T3-L1 cells treated with pVL control, pLV 221, pLV 222, and pLV221/222.

692(C) Western blot analysis of PPARγ in differentiated 3T3-L1 cells treated with pLV-locker

693

control, pLV-locker 221, pLV-locker 222, and pLV-locker 221/222. (D) Western blot analysis

694

of PPARγ in differentiated 3T3-L1 cells treated with pVL control, pLV 221, pLV 222, and695

pLV221/222. (E) Lipolysis assay in 3T3-L1 cells stimulated with isoproterenol.

696

Differentiated 3T3-L1 cells were treated with pLV-locker 221/222 and pLV 221/222. Data

697

shown as mean ± SD and analyzed by one-way ANOVA with Tukey test (*p<0.05;

698**p<0.01).

25

Figure 1
A
Body weight (g)

✱

5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22

✱

B
3

STD-Mir221/222flox/y
STD-Mir221/222AdipoKO
HFHS-Mir221/222flox/y
HFHS-Mir221/222AdipoKO

✱✱✱✱

✱✱✱✱

2

✱✱✱✱

✱✱
✱

✱✱✱

✱✱✱
✱

1

0
Epi

C

Epididymal fat

Mes

Sub

Brown

Adipocyte area (μm2)

Liver

Pancreas

Frequency (%) of adipocyte area

6000
✱

4000

2000

✱

0

D
✱

Figure 2A✱

miR-221-3p

60

STD-Mir221/222flox/y
STD-Mir221/222AdipoKO✱40

HFHS-Mir221/222flox/y
HFHS-Mir221/222AdipoKO
✱✱

✱✱✱✱

✱✱✱
✱✱

✱

✱✱

✱✱
✱

20

✱

✱
✱✱✱✱

✱

✱✱

✱✱

Ep
i

Su
b

t
H
ea
r

ng
Lu

ne
y

Li
ve
r
St
om
ac
h
M
us
cl
e
Pa
nc
re
as
In
te
st
in
e
Sp
le
en
B
ro
w
n

B

K
id

B
ra

in

0

✱✱
✱✱

✱✱✱

✱

✱✱✱✱

✱✱
✱

✱

C

Adipocyte

Relative expression

Relative expression

✱✱

✱✱✱✱

SVF

✱✱✱✱

Adipocyte

SVF

Figure 3A

Mmu-miR-221
Mmu-miR-222

pmirGLO-Ddit4 WT 3’-UTR
pmirGLO-Ddit4 MT 3’-UTR✱✱✱

Reporter activity

pmirGLO-Ddit4 WT 3’-UTR

22
-3
p

21
-3
p
m
um

iR
-2

iR
-2
Sy
nm

m
um

Sy
nm

N

eg
at
iv
e

C
on
tr
ol

pmirGLO-Ddit4 MT 3’-UTR

B
DDIT4(24kDa)GAPDH(37kDa)Mir221/222flox/yMir221/222AdipoKO

p-mTOR/total-mTOR

p-AKT/total-AKT

B✱

p-TSC2/total-TSC2

Figure 4
A

✱

0.4

0.3

0.2

0.1

0.0
✱

Figure 5A
pLV-locker
control

pLV-locker pLV-locker pLV-locker
221
222
221/222

Absorbance at 490nm
0.8

pLV-locker control

0.6

pLV-locker 221

0.4

pLV-locker 222

0.2

B pLV control

pLV-locker 221/222

0.0

pLV 221

pLV 222 pLV 221/222

C
pLV-locker control pLV-locker 221 pLV-locker 222

1.0

C/EBPα(42, 28kDa)
GAPDH(37kDa)C/EBPα/GAPDHPPARγ/GAPDH

PPARγ(53kDa)

0.8
0.6
0.4
0.2
0.0

pLV control

D

pLV control

pLV 221

pLV 222

pLV 221
pLV 222PPARγ(53kDa)C/EBPα(42, 28kDa)
GAPDH(37kDa)C/EBPα/GAPDHPPARγ/GAPDH

1.0
✱✱

✱

0.5

0.0

E
200
150

pLV-locker control
pLV-locker 221/222

100
50
0

Basal Isoproterenol Basal Isoproterenol
0min

120min

C

1.0
✱

✱

0.8

0.8

0.6

0.6
0.4
0.2

0.4

Mir221/222flox/yMir221/222AdipoKO

0.2

0.0

0.0

Light

Dark

Total

Dark

Total

Oxygene consumption

8:
0
9: 0
10 00
11:00
12:00
13:00
14:00
15:00
16:00
17:00
18:00
19:00
20:00
21:00
22:00
23:00
24:00
:0
1: 0
0
2: 0
0
3: 0
0
4: 0
0
5: 0
00
6:
00

B

1.0

8:
0
9 0
10:00
11:00
12:00
13:00
14:00
15:00
16:00
17:00
18:00
19:00
20:00
21:00
22:00
23:00
24:00
:0
1: 0
0
2: 0
00
3:
0
4: 0
0
5: 0
00
6:
00

A

Respiratory quotient

Supplementary Figure 1

30

20

25
20

Mir221/222flox/yMir221/222AdipoKO

15
10

10

✱

5
0
8:
0
9: 0
10 00
:
11 0 0:
12 00:
13 0 0:
14 00:
15 0 0
:
16 00
:0
17 0
:
18 00
:0
19 0
:
20 00
:0
21 0
:
22 00
:
23 00
:0
0: 0
0
1: 0
0
2: 0
00
3:
0
4: 0
00
5:
0
6: 0
0
7: 0
00

0

D

E

✱

30

Light

F

20

10

0

Supplementary Figure 1. Basal metabolic rate, locomotor activity and food intake. (Aand B) Respiratory quotient (RQ) and Oxygen consumption rate in Mir221/222flox/y(n=11) and Mir221/222AdipoKO (n=10) mice fed with HFHS (high fat high sucrose)chow. (C) Locomotor activity in Mir221/222flox/y (n=10) and Mir221/222AdipoKO (n=9)
mice fed with HFHS chow. (D) Food consumption in Mir221/222flox/y (n=5) and
Mir221/222AdipoKO (n=10) mice fed with HFHS chow. (E) Serum leptin levels in
Mir221/222flox/y (n=8) and Mir221/222AdipoKO (n=6) mice fed with HFHS chow. (F)Serum adiponectin levels in Mir221/222flox/y (n=8) and Mir221/222AdipoKO (n=6) mice
fed with HFHS chow. Data shown as mean ± SD and analyzed by Mann-Whitney's U
test (*p<0.05).

Supplementary Figure 2✱

Supplementary Figure 2. mRNA expression of various genes. Mir221/222flox/y (n=5) and
Mir221/222AdipoKO (n=5) mice fed with HFHS (high fat high sucrose) chow. Data shownas mean ± SD and analyzed by Mann-Whitney's U test (*p<0.05).

Supplementary Figure 3

A

miR-222-3p expression after differentiation
1.5(DEX/IBMX/INS)
1.0

✱✱✱✱

✱✱✱✱

0.5

0.0
0

B

2

4

6

10 12 14 16 18 20 (day)8

miR-222-3p

2.5
2.0

✱✱
✱

✱

1.5

✱✱✱
✱✱✱

✱✱
✱✱✱

✱✱✱
✱✱✱

✱✱✱
✱✱✱

1.0
0.5
0.0

Day3

Day5

Day7

miR-221-3p

6

✱✱✱✱
✱✱✱✱

4
✱✱✱✱

✱✱✱✱

✱✱✱✱

✱✱✱✱

Day3

Day4

✱✱✱✱
✱✱✱✱

2

0

Day5

Relative expression

C

Day4

✱✱✱✱
✱✱✱✱
✱✱✱✱
✱✱✱✱

✱✱✱✱
✱✱✱✱

✱✱✱✱
✱✱✱✱

Day7

Supplementary Figure 3. Expression of miR-221-3p and miR-222-3p in 3T3-L1 cells.
(A) Expression of miR-221-3p and miR-222-3p after the induction of adipocyte
differentiation by dexamethasone, isobutylmethylxanthine, 1-methyl-3-isobutylxanthineand insulin (DEX/IBMX/INS). (n=3) (B) Expression of miR-221-3p and miR-222-3p in
3T3L1 cells treated with pLV-locker control, pLV-locker 221, and pLV-locker 222. (C)Expression of miR-221-3p and miR-222-3p in 3T3-L1 cells treated with pVL control, pLV
221, and pLV 222. Data shown as mean ± SD and analyzed one-way ANOVA with
Tukey test (*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001).

Supplementary Figure 4
4

Relative expression

A

Serum

STD-Mir221/222flox/y2

STD-Mir221/222AdipoKO0

HFHS-Mir221/222flox/y
HFHS-Mir221/222AdipoKO-2

LogmiR-221

B

C

LogmiR-222

5

HbA1c

*

0
5

10

15

-5
-10
-15

NGT
R2=0.1311**** P<0.0001

IGT

Supplementary Figure 4. Serum concentration of mir-221-3p and mir-222-3p levels in miceand human. (A) Serum concentrations of mir-221-3p and mir-222-3p levels in Mir221/222flox/y(n=14) and Mir221/222AdipoKO (n=13) mice fed with STD (standard) chow, Mir221/222flox/y(n=19) and Mir221/222AdipoKO (n=24) mice fed with HFHS (high fat high sucrose) chow . (B)Simple correlations of serum miR-221-3p and miR-222-3p levels with various clinical parametersin the subjects with normal glucose tolerance (NGT, n=45) and impaired glucose tolerance (IGT,n=69) (n=114). In correlation matrix, Spearman's rank correlation coefficient is shown. *p<0.05,**p<0.01. (C) Log hsa-miR-221-3p negatively correlates with HbA1c, while Log hsa-miR-222-3p
positively correlates with HbA1c.

Supplementary Figure 5
A

Mouse miR-221 host gene on Mir221/222 KO targeting vector

1

1537

1055

1054

B
✱✱

✱

✱

✱

✱✱

✱✱✱✱

✱✱✱✱

✱✱

✱✱✱
✱✱
✱✱

C
Relative expression

✱
✱✱✱✱

✱

✱✱

✱✱✱✱
✱
✱✱

✱✱✱
✱✱

Ep
i

Su
b

n
w
B
ro

us
cl
e
Pa
nc
re
as
In
te
st
in
e
Sp
le
en

M

ac
h
m

ve
r

St
o

Li

t
ea
r
H

ng
Lu

ne
y
id

K

B

ra

in

✱✱

Supplementary Figure 5. Expression of miR-221 host gene (Mir221hg) in various
tissues. (A) Mir221/222 KO targeting vector map and location of miR-221 host gene
(Mir221hg). The single exon of Mir221hg is disrupted by NEO. (B and C) Expression of
Mir221hg in various tissues in Mir221/222flox/y (n=5) and Mir221/222AdipoKO (n=6) mice
fed with STD (standard) chow, Mir221/222flox/y (n=3) and Mir221/222AdipoKO (n=5) mice
fed with HFHS (high fat high sucrose) chow. Whole range of relative expression (0 to 80)
is shown in panel B and narrow range (0 to 20) in panel C. Data shown as mean ± SD
and analyzed by one-way ANOVA with Tukey test. (*p<0.05; **p<0.01; ***p<0.001;****p<0.0001).

Supplementary Figure 6

Uncropped images in Figure 3B
DDIT4

GAPDH

Uncropped images in Figure 4A
p-AKT

total-AKT

p-TSC2

total-TSC2

p-mTOR

total-mTOR

Supplementary Figure 7

Uncropped images in Figure 4A
p-S6K

total-S6K

GAPDH

Uncropped images in Figure 5C,D

C
PPARγ

GAPDH

PPARγ

GAPDH

C/EBPαD
C/EBPαSupplementary Figure 8

Mir221/222

High fat-high sucrose diet (HFHS)P

Activated form

Inhibition of Mir221/222

P

Inactivated form

TSC1
DDIT4

TSC2
P T1462

Rheb
AKT
P

mTORC1GDP

S6K
P

Adipogenesis and lipogenesis
Obesity

Supplementary Figure 8. Ddit4 is a direct target of miR-221-3p and miR-222-3p andit inhibits mTORC1 pathway.

Supplementary Table 1. Formulation of standard (STD) and high fat-high sucrose (HFHS) chow.

Nutrients / 1000 g chow

Macronutrients

Carbohydrate contents

STD

HFHS

(MF, Oriental Yeast, Japan*)(D12331, Research Diets, New Brunswick, NJ**)

Protein (g)226.6

Carbohydrate (g)

553

230
345

Fat (g)51

358.5

Maltodextrin (g)0170Corn starch (g)00Sucrose (g)0175553 (as soluble nitrogen-free productfrom crude mixture of corn, wheat andrice bran)

Vitamin

MineralVit A (IU)

12830

4000

Vit D3 (IU)

1370

1000

Vit E (mg)91

50

Vit K3 (mg)

0.4

0.5

Vit B1 (mg)

20.5

6

Vit B2 (mg)11

6

Vit B6 (mg)8.7

7

Vit B12 (μg)

5510Biotin (μg)

270

200

Pantothenic acid (mg)

24.5

16

Niacin (mg)

106.1

30

Choline (g)

1.8

0.62

Folic acid (mg)1.7

2

Ca (g)

10.7

5.94
4.57

P (g)

8.3

Mg (g)

2.4

0.57

Na (g)

1.9

1.14
4.11

K (g)

9

Fe (mg)106

42.3

Cu (mg)

7.8

6.86

Zn (mg)

48.9

33.1

Mn (mg)

48.4

67.4

Total calories (kcal)

3590

5560

*https://www.oyc.co.jp/bio/LAD-equipment/LAD/ingredient.html and https://www.oyc.co.jp/bio/LAD-equipment/LAD/rodents.html**https://www.eptrading.co.jp/service/researchdiets/pdf/D12328-D12331.pdf

Supplementary Table 2 RNA sequencing data sera, liver and epididymalfat tissues in C57BL/6J mice fed with standard (STD) and high fat-high sucrose chow (HFHS).

miRBase Name

mmu-mir-504
mmu-mir-703
mmu-mir-298
mmu-mir-335
mmu-mir-342
mmu-mir-222
mmu-mir-296
mmu-mir-211
mmu-mir-18b
mmu-mir-1193
mmu-mir-122
mmu-mir-669d
mmu-mir-301b
mmu-mir-221
mmu-mir-802
mmu-mir-592
mmu-mir-412
mmu-mir-494
mmu-mir-499
mmu-mir-31
mmu-mir-146a
mmu-mir-147
mmu-mir-692-1
mmu-mir-1199
mmu-mir-679
mmu-mir-190
mmu-mir-146b
mmu-mir-380
mmu-mir-20b
mmu-mir-684-1
mmu-mir-684-2
mmu-mir-704
mmu-mir-669e
mmu-mir-376a
mmu-mir-455
mmu-mir-487b
mmu-mir-496
mmu-mir-551b
mmu-mir-340
mmu-mir-376b
mmu-mir-370
mmu-mir-377
mmu-mir-142
mmu-mir-692-2
mmu-mir-433
mmu-mir-214
mmu-mir-543
mmu-mir-369
mmu-mir-155
mmu-mir-669a-2
mmu-mir-501
mmu-mir-669a-1
mmu-mir-411
mmu-mir-299
mmu-mir-130b
mmu-mir-297b
mmu-mir-136
mmu-mir-106a
mmu-mir-449c
mmu-mir-18a
mmu-mir-652
mmu-mir-9-1
mmu-mir-9-2
mmu-mir-297a-6
mmu-mir-297a-1
mmu-mir-297a-2
mmu-mir-511
mmu-mir-540
mmu-mir-598
mmu-mir-9-3
mmu-mir-223
mmu-mir-382
mmu-mir-205
mmu-mir-409
mmu-mir-379
mmu-mir-337
mmu-mir-323
mmu-mir-297c
mmu-mir-466d
mmu-mir-410
mmu-mir-297a-4
mmu-mir-297a-3
mmu-mir-363
mmu-mir-485
mmu-mir-34c
mmu-mir-141
mmu-mir-329
mmu-mir-376c
mmu-mir-541
mmu-mir-542
mmu-mir-467a
mmu-mir-434

miRBase Accession

LINK

MI0005515
MI0004687
MI0000398
MI0000817
MI0000627
MI0000710
MI0000394
MI0000708
MI0005483
MI0006298
MI0000256
MI0006281
MI0004122
MI0000709
MI0004249
MI0004127
MI0001164
MI0003532
MI0004676
MI0000579
MI0000170
MI0005482
MI0004660
MI0006307
MI0004638
MI0000232
MI0004665
MI0000797
MI0003536
MI0004647
MI0004648
MI0004688
MI0006300
MI0000793
MI0004679
MI0003534
MI0004589
MI0004131
MI0000623
MI0001162
MI0001165
MI0000794
MI0000167
MI0004661
MI0001525
MI0000698
MI0003519
MI0003535
MI0000177
MI0004667
MI0004703
MI0004523
MI0001163
MI0000399
MI0000408
MI0004674
MI0000162
MI0000406
MI0004645
MI0000567
MI0004965
MI0000720
MI0000157
MI0005491
MI0000395
MI0000397
MI0005554
MI0003518
MI0005556
MI0000721
MI0000703
MI0000799
MI0000248
MI0001160
MI0000796
MI0000615
MI0000592
MI0005492
MI0005546
MI0001161
MI0005489
MI0005488
MI0000765
MI0003492
MI0000403
MI0000166
MI0000605
MI0003533
MI0003521
MI0003522

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MI0001526

miRBase_LINK

s3
s1(Serum- s2(Liver-High(Epididymal
High fat highfat highfat-High fat
sucrosesucrosehigh sucrose
chow)
chow)
chow)

5
1
188
137
2,027
1,039
287
17
4
0
723
0
80
7,180
167
27
0
4
56
297
2,113
4
3
8
3
1
663
1
5
1
1
1
0
7
54
15
2
3
1,859
3
7
11
37,026
10
21
170
0
4
123
15
60
165
136
15
4,382
1
182
3
1
754
1,121
3
3
0
0
0
332
55
12
3
1,534
7
2,127
125
1
53
1
0
2
149
0
0
21
48
230
273
21
2
769
17
8
2,057

0
112
28
2,673
1,124
1,763
10
18
3
0
392,4840
7
6,724
33,519
66
0
3
9
8,935
2,851
4
76
8
1
485
676
6
6
3
3
2
0
7
4,687
1
1
116
27,0069
0
2
17,590
328
0
682
3
11
122
49
65
512
350
4
91
9
185
2
0
261
348
25
25
0
0
0
663
6
162
25
857
4
108
25
10
11
1
7
4
51
8
7
5
7
153
404
10
8
207
224
170
403

1,177
13
3,175
110,365
19,32022,488
454
7
7
26
409
12
91
38,010
25
25
4
252
82
189
9,532
96
16
22
90
713
20,505
207
57
6
6
3
3
366
882
208
262
8
19,256362
53
271
58,187
66
191
3,121
102
718
1,336
439
342
4,545
35,343
735
614
30
8,157
16
25
410
1,394
259
259
18
9
9
985
497
264
259
7,087
333
71
1,891
784
1,263
39
26
28
5,073
36
36
110
338
7,548
88
888
249
15,707534
1,476
37,349s5 (SerumNormalchow)

s6 (LiverNormal
chow)

s7
(Epididymal
fat-Normal
chow)

5
4
379
54
3,427
2,231
387
23
7
0
494
0
107
9,165
64
24
0
29
109
382
4,266
7
7
9
7
0
1,766
5
10
0
0
2
0
0
59
26
11
1
2,661
11
6
11
39,676
56
45
250
21
29
251
62
106
668
272
31
5,414
0
428
3
0
823
1,288
9
9
20
10
10
683
147
5
9
2,369
38
6,337
374
11
115
14
0
11
477
10
10
71
157
295
370
72
6
1,541
31
8
5,758

0
170
30
1,504
707
1,578
20
9
0
1
367,471
0
4
7,541
7,020
348
0
5
5
11,471
4,742
6
63
4
1
325
859
6
6
10
10
8
0
10
5,597
0
6
27
22,296
14
0
3
9,631
254
2
655
3
12
105
41
66
416
498
17
88
0
288
1
0
214
265
6
6
2
1
1
687
8
176
6
671
8
43
40
25
21
0
0
5
40
1
1
3
3
357
272
14
3
288
185
171
670

29
1
249
8,778
2,040
2,759
63
1
1
4
65
2
16
6,710
5
6
1
67
23
55
2,822
29
5
7
29
231
6,707
68
19
2
2
1
1
132
324
77
97
3
7,227
136
20
103
22,754
26
76
1,245
41
291
542
180
141
1,880
14,732
310
260
13
3,543
7
11
181
616
115
115
8
4
4
439
222
118
116
3,189
150
32
857
356
574
18
12
13
2,383
17
17
52
160
3,585
42
424
120
7,593
259
716
18,279

Total

1,216
301
4,049
123,51128,64531,858
1,221
75
22
31
761,64614
305
75,33040,800
496
5
360
284
21,32926,326
146
170
58
131
1,755
31,176
293
103
22
22
17
4
522
11,603327
379
158
80,305535
86
401
184,864
740
335
6,123
170
1,065
2,479
786
780
8,186
51,331
1,112
10,84953
12,783
32
37
2,643
5,032
417
417
48
24
24
3,789
935
737
418
15,707
540
8,718
3,312
1,187
2,037
73
45
63
8,173
72
71
262
713
12,168
1,449
1,429
388
26,1051,250
2,549
64,516

s1/s5

s2/s6

s3/s7

1.000
0.250
0.496
2.537
0.591
0.466
0.742
0.739
0.571
#DIV/0!
1.464#DIV/0!
0.748
0.783
2.609
1.125
#DIV/0!
0.138
0.514
0.777
0.495
0.571
0.429
0.889
0.429
#DIV/0!
0.375
0.200
0.500
#DIV/0!
#DIV/0!
0.500#DIV/0!
#DIV/0!
0.915
0.577
0.182
3.000
0.699
0.273
1.167
1.000
0.933
0.179
0.467
0.680
0.000
0.138
0.490
0.242
0.566
0.247
0.500
0.484
0.809
#DIV/0!
0.425
1.000#DIV/0!
0.916
0.870
0.333
0.333
0.000
0.000
0.000
0.486
0.374
2.400
0.333
0.648
0.184
0.336
0.334
0.091
0.461
0.071
#DIV/0!
0.182
0.312
0.000
0.000
0.296
0.306
0.780
0.738
0.292
0.333
0.499
0.548
1.000
0.357

#DIV/0!
0.659
0.933
1.777
1.590
1.117
0.500
2.000
#DIV/0!
0.000
1.068#DIV/0!
1.750
0.892
4.775
0.190
#DIV/0!
0.600
1.800
0.779
0.601
0.667
1.206
2.000
1.000
1.492
0.787
1.000
1.000
0.300
0.300
0.250
#DIV/0!
0.700
0.837#DIV/0!
0.167
4.296
1.211
0.643
#DIV/0!
0.667
1.826
1.291
0.000
1.041
1.000
0.917
1.162
1.195
0.985
1.231
0.703
0.235
1.034
#DIV/0!
0.642
2.000#DIV/0!
1.220
1.313
4.167
4.167
0.000
0.000
0.000
0.965
0.750
0.920
4.167
1.277
0.500
2.512
0.625
0.400
0.524
#DIV/0!
#DIV/0!
0.800
1.275
8.000
7.000
1.667
2.333
0.429
1.485
0.714
2.667
0.719
1.211
0.994
0.601

40.58613.00012.751
12.573
9.471
8.151
7.206
7.000
7.000
6.500
6.292
6.000
5.688
5.665
5.000
4.167
4.000
3.761
3.565
3.436
3.378
3.310
3.200
3.143
3.103
3.087
3.057
3.044
3.000
3.000
3.000
3.000
3.000
2.773
2.722
2.701
2.701
2.667
2.664
2.662
2.650
2.631
2.557
2.538
2.513
2.507
2.488
2.467
2.465
2.439
2.426
2.418
2.399
2.371
2.362
2.308
2.302
2.286
2.273
2.265
2.263
2.252
2.252
2.250
2.250
2.250
2.244
2.239
2.237
2.233
2.222
2.220
2.219
2.207
2.202
2.200
2.167
2.167
2.154
2.129
2.118
2.118
2.115
2.113
2.105
2.095
2.094
2.075
2.069
2.062
2.061
2.043

mmu-mir-199a-1
mmu-mir-199a-2
mmu-mir-27b
mmu-mir-34b
mmu-mir-375
mmu-mir-200c
mmu-mir-466b-3
mmu-mir-539
mmu-mir-547
mmu-mir-669h
mmu-mir-199b
mmu-mir-181d
mmu-mir-674
mmu-mir-23b
mmu-mir-495
mmu-mir-134
mmu-mir-431
mmu-mir-466c
mmu-mir-669a-3
mmu-mir-181c
mmu-mir-32
mmu-mir-505
mmu-mir-15b
mmu-mir-466b-1
mmu-mir-466a
mmu-mir-500
mmu-mir-322
mmu-mir-450b
mmu-mir-466b-2
mmu-mir-450a-1
mmu-let-7i
mmu-mir-450a-2
mmu-mir-149
mmu-mir-34a
mmu-mir-466e
mmu-mir-300
mmu-mir-21
mmu-mir-362
mmu-mir-381
mmu-mir-467b
mmu-mir-15a
mmu-mir-181a-1
mmu-mir-181a-2
mmu-mir-148b
mmu-mir-182
mmu-mir-677
mmu-mir-127
mmu-mir-201
mmu-mir-128-2
mmu-mir-666
mmu-mir-17
mmu-mir-421
mmu-mir-7a-2
mmu-mir-24-1
mmu-mir-184
mmu-mir-297a-5
mmu-mir-128-1
mmu-mir-132
mmu-mir-126
mmu-mir-665
mmu-mir-16-1
mmu-mir-24-2
mmu-mir-341
mmu-mir-1-2-as
mmu-mir-16-2
mmu-mir-212
mmu-mir-185
mmu-mir-301a
mmu-mir-467c
mmu-mir-326
mmu-mir-668
mmu-mir-152
mmu-mir-452
mmu-mir-673
mmu-mir-667
mmu-mir-186
mmu-mir-19a
mmu-mir-669c
mmu-mir-700
mmu-mir-23a
mmu-mir-139
mmu-mir-27a
mmu-mir-19b-1
mmu-mir-19b-2
mmu-mir-7a-1
mmu-mir-138-2
mmu-mir-194-2
mmu-mir-338
mmu-mir-98
mmu-mir-689-1
mmu-mir-30b
mmu-mir-879
mmu-mir-669f
mmu-mir-466f-2
mmu-mir-466f-3
mmu-mir-325
mmu-mir-20a
mmu-mir-708

MI0000241
MI0000713
MI0000142
MI0000404
MI0000792
MI0000694
MI0005504
MI0003520
MI0003523
MI0006289
MI0000714
MI0005450
MI0004611
MI0000141
MI0004639
MI0000160
MI0001524

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0004668
MI0000724
MI0000691
MI0004706
MI0000140
MI0005502
MI0002401
MI0004702
MI0000590
MI0004705
MI0005503
MI0001653
MI0000138
MI0003537
MI0000171
MI0000584
MI0005506
MI0000400
MI0000569
MI0000763
MI0000798
MI0004671
MI0000564
MI0000697
MI0000223
MI0000617
MI0000224
MI0004634
MI0000154
MI0000244
MI0000726
MI0004553
MI0000687
MI0005496
MI0000729
MI0000231
MI0000226
MI0005490
MI0000155
MI0000158
MI0000153
MI0004171
MI0000565
MI0000572
MI0000625

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0000566
MI0000696
MI0000227
MI0000401
MI0005512
MI0000598
MI0004134
MI0000174
MI0001734
MI0004601
MI0004196
MI0000228
MI0000688
MI0004673
MI0004684
MI0000571
MI0000693
MI0000578
MI0000718
MI0000546
MI0000728
MI0000164
MI0000733
MI0000619
MI0000586

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0000145
MI0005472
MI0006287
MI0005508
MI0005509
MI0000597
MI0000568
MI0004692

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

4,296
4,297
22,994
36
8,270
72
7
2
0
0
4,178
1,317
417
485
0
16
41
24
15
5,818
22
28
3,219
48
8
34
281
35
8
22
36,717
22
1,128
31
16
65
33,91319155
113,12150,78150,960
513
1,221
5
1,751
4
2,971
2
1,299
2,166
3
335
20
0
3,329
471
13,581
1
270,173790
25
0
270,034
42
91
1,103
1
212
27
183
0
58
18
20,174
151
1
27
4,046
339
2,777
1,366
1,368
51
271
636
58
1,262
1,919
13,651
0
0
2
2
0
239
1

18,27018,289253,279
11
137
54
6
0
1
0
17,125
353
377
8,475
8
5
11
33
23
5,782
1,000
79
1,918
54
8
141
1,774
278
9
514
37,261
512
2,485
784
16
41
675,905379
59
16
19,58554,61754,7803,255
16,422
364
714
58
452
1
1,972
285
335
2,267
15
0
596
396
210,6170
109,3503,781
8
2
108,238
76
1,001
1,619
5
287
0
2,975
3
7
1
17,459
444
18
52
3,914
2,056
8,389
5,002
5,031
465
98
160,390
581
8,984
2,643
52,808
56
4
0
0
0
2,168
8

111,847
111,987
390,605
547
12
22
54
14
2
2
107,930
2,840
1,656
16,917
220
239
1,110
276
157
34,967
1,235
112
5,791
438
71
627
18,296
1,238
72
1,665
191,131
1,654
2,990
5,181
142
2,666
833,457
709
4,680
104
20,015
675,748
672,973
3,523
1,562
237
68,083
7
944
108
2,333
1,204
171
13,600
98
12
1,171
1,704
507,38242
189,081
25,120662
5187,705
326
765
4,351
43
2,204
224
10,11336453
12351,457149
91
258
44,281
9,577
65,837
2,546
2,540
333
1,608
2,112
1,375
18,0092,029
70,119
9
12
9
6
3
1,656
11,0799,449
9,449
29,301
20
4,163
119
8
0
0
0
9,223
2,036
623
745
9
101
158
21
48
8,210
7
27
3,407
48
7
74
320
37
8
16
43,314
17
1,681
63
16
179
57,30016340
112,93491,80692,313
540
1,891
22
3,850
3
4,817
6
1,142
2,543
5
604
73
10
5,477
621
15,175
10274,3991,311
69
0274,225
75
91
1,210
0
313
96
298
6
168
51
22,453
147
10
23
7,353
382
3,388
1,374
1,375
33
488
566
64
1,521
2,160
16,874
3
0
4
0
0
306
7

25,27825,297245,960
30
133
40
6
0
10
0
24,025
506
267
8,883
8
9
9
45
6
10,013
656
58
1,569
53
10
162
1,581
257
9
547
35,448
549
598
427
18
53
872,282348
85
17
17,33353,25053,412
2,943
12,825
363
1,120
52
322
0
1,540
263
328
2,923
50
1
450
356
201,4220
112,2654,695
5
2
111,159
64
901
1,203
4
417
2
2,440
4
4
1
16,000
382
7
72
5,152
1,835
8,827
5,222
5,241
492
60
142,987
681
8,447
2,465
43,695
34
2
0
1
0
1,918
0

55,29455,364
193,911
273
6
11
27
7
1
1
54,220
1,429
836
8,549
114
124
579
144
82
18,384
650
59
3,074
234
38
337
9,847
670
39
903
103,687
901
1,635
2,838
78
1,469
459,536
392
2,600
58
11,210380,583
380,437
1,992
888
135
38,800
4
540
62
1,340
694
99
7,887
57
7
688
1,010
301,18225
113,203
15,056397
3112,639
196
462
2,629
26
1,335
136
6,141
22
277
76
31,8509357
163
28,227
6,106
42,164
1,633
1,632
217
1,059
1,393
910
11,921
1,349
46,626
6
8
6
4
2
1,114
7,466

224,434
224,683
1,136,050
917
12,721
318
108
23
14
3
216,701
8,481
4,176
44,054
359
494
1,908
543
331
83,174
3,570
363
18,978
875
142
1,375
32,099
2,515
145
3,667
447,558
3,655
10,517
9,324
286
4,473
2,932,393
1,863
7,919
197
94,1981,306,785
1,304,875
12,76634,8091,126
114,318128
10,046
179
9,626
7,155
941
27,616313
30
11,711
4,558
1,249,359
78
1,068,471
50,7531,166
121,064,000
779
3,311
12,11579
4,768
485
22,15071
967
270
159,393
1,366
184
595
92,973
20,295
131,382
17,143
17,1871,591
3,584
308,084
3,669
50,144
12,565
243,773
108
26
21
13
5
7,401
18,561

0.455
0.455
0.785
1.800
1.987
0.605
0.875
#DIV/0!
#DIV/0!
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0.647
0.669
0.651
0.000
0.158
0.259
1.143
0.313
0.709
3.143
1.037
0.945
1.000
1.143
0.459
0.878
0.946
1.000
1.375
0.848
1.294
0.671
0.492
1.000
0.363
0.592
1.188
0.456
1.000
1.014
0.553
0.552
0.950
0.646
0.227
0.455
1.333
0.617
0.333
1.137
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0.600
0.555
0.274
0.000
0.608
0.758
0.895
0.100
0.985
0.603
0.362
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0.985
0.560
1.000
0.912
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0.677
0.281
0.614
0.000
0.345
0.353
0.898
1.027
0.100
1.174
0.550
0.887
0.820
0.994
0.995
1.545
0.555
1.124
0.906
0.830
0.888
0.809
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0.781
0.143

0.723
0.723
1.030
0.367
1.030
1.350
1.000
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0.100#DIV/0!
0.713
0.698
1.412
0.954
1.000
0.556
1.222
0.733
3.833
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1.362
1.222
1.019
0.800
0.870
1.122
1.082
1.000
0.940
1.051
0.933
4.156
1.836
0.889
0.774
0.775
1.089
0.694
0.941
1.130
1.026
1.026
1.106
1.280
1.003
0.638
1.115
1.404
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1.084
1.021
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0.300
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1.324
1.112
1.046
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0.805
1.600
1.000
0.974
1.188
1.111
1.346
1.250
0.688
0.000
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0.750
1.750
1.000
1.091
1.162
2.571
0.722
0.760
1.120
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0.958
0.960
0.945
1.633
1.122
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1.072
1.209
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2.023
2.014
2.004
2.000
2.000
2.000
2.000
2.000
2.000
1.991
1.987
1.981
1.979
1.930
1.927
1.917
1.917
1.915
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1.900
1.898
1.884
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1.846
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1.776
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1.769
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1.756
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1.750
1.748
1.742
1.741
1.735
1.727
1.724
1.719
1.714
1.702
1.687
1.685
1.680
1.670
1.668
1.668
1.667
1.666
1.663
1.656
1.655
1.654
1.651
1.647
1.647
1.636
1.635
1.618
1.616
1.602
1.596
1.583
1.569
1.568
1.561
1.559
1.556
1.535
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1.511
1.511
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338,851 3,965,596 4,079,202
10
58
218
3,670
2,242
28,133646
159,842
2,109
3,625
2,174
27,208
6
4
208
26
17
19
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2
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6
29
3,030
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1
4
166
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744
892
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42
10
7
6
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905
5,291
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86,140170,538
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0
0
7
245
2,198
23,070
272
2,552
5,554
55,437 2,530,616
20,099
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3,379
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1,276
1,495
3,443
14
27
182
128
655
75
66
34,4808,415
1,277
88,76958,100
108
360
465
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0
4
141
41
169
0
5
13
17,105
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24
67
302
16,610684,828
778,838
3
9
72
16
2
45
11,642
621,181
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10
10
38
728
1,949
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4,225
87,41889,191
1,799
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1,844
4,994
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122
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372
297
956
0
0
16
55,077
14,24816,921
0
1
11
340
422
1,977
691
7,653
8,991
534
3,481
28,628
5,323
4,145
8,496
10,609903,788326,358
9,486
31,203
95,0308
54
77
175,527
26,684
63,12022,232229,736
311,658
22,147
227,308
310,10765,73870,411
197,169
636
1,706
2,271
74
3,496
2,779
19,63951,63774,003
40
725
244
69
965
216
47,426
11,01718,802
1
3
16
0
5
8
82
3,524
2,730
382
43
341
72,776
164,719345,608
72,525
161,513342,882
261,995
104,687
72,981
99,452
9,614
12,718
59
313
543
86
57
723
43,250244,759 1,008,625
6,202
2,127
6,702
192
2,938
9,649
1,567
320
489
42,293
14,73827,822
184
2,901
9,541
3,001
1,716
5,549
808
23,42010,962
242
1
2,752
269
1,910
12,916
8,013
34,832
68,0991,894
215,325
19,2591,701
23,074
11,68820,875
307,684
793,505
20,871
307,545793,290
26,388278,402 2,360,422
77
119
62
0
273
1
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6
8
26
76
14
4
0
2
6
1
1

420,007 4,183,928 2,763,563 15,751,147
32
49
148
515
6,614
2,261
19,12862,048615
142,468
1,435
307,115
6,530
2,188
18,56160,286
15
0
142
375
32
23
13
130
80,846
193,52186,176
718,833
48
3
20
127
0
0
20
55
4,082
3,515
9,271
36,994
10
0
115
296
138
797
622
3,317
23
47
7
151
14
14
206
541
1,108
5,683
44,269119,976
1,134
3,115
5,662
21,880146,223
200,896
251,104
1,207,353
0
0
5
12
321
2,860
16,52345,217
463
2,370
3,998
15,20955,249 2,670,751
14,5505,346,702
8,151
2,647
4,085
29,202
2,826
1,397
2,512
12,949
19
10
133
385
334
426
55
1,673
105
50,4886,215
99,7691,312
74,11943,132
266,709
268
84
346
1,631
0
0
3
9
245
25
128
749
0
5
10
33
32,701
9,330
6,780
84,908
41
66
234
734
25,149593,665
604,641
2,703,731
2
14
56
156
9
2
35
109
17,964543,185572,647
2,497,990
19
2
30
109
1,116
1,585
1,382
8,504
4,349
85,18770,989341,359
2,217
2,337
5,264
23,13328,263143,036
88,635515,946
5,858
1,315
4,045
22,552
30
144
158
657
432
198
775
3,030
0
0
13
29
89,556
11,061
13,761200,624
8
1
9
30
429
427
1,619
5,214
1,027
5,588
7,377
31,327
1,146
5,389
23,56062,738
7,343
3,756
6,993
36,056
11,294998,441
270,135
2,520,625
15,28327,32878,781
257,1113
50
64
256
155,992
15,66352,887
489,873
32,557244,268
263,340
1,103,791
32,488242,059
262,321
1,096,430
98,887
77,767
166,952
676,924
802
1,446
1,938
8,799
103
3,291
2,396
12,13928,501
42,11764,215
280,112
44
431
212
1,696
171
1,558
188
3,167
58,767
7,978
16,400160,390
8
3
14
45
6
4
7
30
111
3,061
2,393
11,901
684
119
309
1,878
118,692
170,389
313,353
1,185,537
118,216
167,212311,496
1,173,844
307,148
106,440
66,478919,729
113,997
8,089
11,624
255,494
66
246
497
1,724
145
74
664
1,749
60,325
314,615935,7622,607,336
8,368
2,369
6,222
31,990
192
2,696
8,997
24,664
1,670
268
456
4,770
42,227
14,05326,003
167,136
186
2,657
8,918
24,387
4,209
1,221
5,249
20,945867
17,393
10,512
63,962
376
0
2,661
6,032
476
2,406
12,49330,47013,08833,23966,095
223,366
1,459
154,713
18,731
411,381
4,293
23,155
11,38075,291
25,269366,153
780,7032,294,189
25,267
365,994
780,582
2,293,549
31,475452,685 2,327,301
5,476,673
76
112
62
508
0
179
1
454
194
16
8
331
33
102
14
265
6
1
2
15
0
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1
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0.807
0.313
0.555
1.050
0.555
0.400
0.813
0.763
0.521
#DIV/0!
0.742
0.100
0.899
0.957
0.500
0.817
0.600
0.589
#DIV/0!
0.763
0.587
1.003
0.652
0.452
0.737
0.383
0.629
0.973
0.403
#DIV/0!
0.576#DIV/0!
0.523
0.585
0.660
1.500
1.778
0.648
0.526
0.652
0.971
0.811
0.862
0.767
0.267
0.861
#DIV/0!
0.615
0.000
0.793
0.673
0.466
0.725
0.939
0.621
2.667
1.125
0.683
0.682
0.665
0.793
0.718
0.689
0.909
0.404
0.807
0.125
0.000
0.739
0.558
0.613
0.613
0.853
0.872
0.894
0.593
0.717
0.741
1.000
0.938
1.002
0.989
0.713
0.932
0.644
0.565
0.612
1.298
0.396
0.826
0.826
0.838
1.013
#DIV/0!
0.510
0.788
0.667
#DIV/0!

0.948
1.184
0.992
1.122
0.994
#DIV/0!
0.739
0.882
0.667
#DIV/0!
1.046#DIV/0!
0.934
0.894
0.429
0.931
1.055
0.849
#DIV/0!
0.769
1.077
0.948
1.277
1.070
2.700
1.538
0.683
1.198
4.286
#DIV/0!
1.640
1.000
1.097
1.015
1.154
0.643
1.000
1.144
5.000
1.230
1.026
2.122
0.851
1.402
0.847
1.500
#DIV/0!
1.288
1.000
0.988
1.370
0.646
1.104
0.905
1.142
1.080
1.704
0.941
0.939
0.905
1.180
1.062
1.226
1.682
0.619
1.381
1.000
1.250
1.151
0.361
0.967
0.966
0.984
1.189
1.272
0.770
0.778
0.898
1.090
1.194
1.049
1.092
1.405
1.347
#DIV/0!
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1.048
1.392
0.997
0.840
0.840
0.615
1.063
1.525
0.375
0.745
0.000
0.250

1.476
1.473
1.471
1.470
1.466
1.465
1.462
1.461
1.450
1.450
1.447
1.443
1.434
1.429
1.427
1.417
1.413
1.404
1.400
1.396
1.389
1.381
1.378
1.371
1.368
1.364
1.354
1.347
1.344
1.333
1.320
1.300
1.291
1.291
1.288
1.286
1.286
1.277
1.267
1.262
1.256
1.246
1.241
1.235
1.234
1.234
1.231
1.230
1.222
1.221
1.219
1.215
1.215
1.208
1.206
1.203
1.193
1.183
1.182
1.181
1.172
1.160
1.152
1.151
1.149
1.146
1.143
1.143
1.141
1.104
1.103
1.101
1.098
1.094
1.093
1.089
1.078
1.077
1.072
1.072
1.070
1.070
1.057
1.043
1.034
1.034
1.030
1.028
1.027
1.016
1.016
1.014
1.000
1.000
1.000
1.000
1.000
1.000

mmu-mir-292
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mmu-mir-218-2
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mmu-mir-210
mmu-mir-135b
mmu-mir-378
mmu-mir-345
mmu-mir-486
mmu-mir-133a-1
mmu-mir-133a-2
mmu-mir-196b
mmu-mir-208b
mmu-mir-193b
mmu-mir-217
mmu-mir-219-2
mmu-mir-384
mmu-mir-670
mmu-mir-135a-2
mmu-mir-135a-1
mmu-mir-483
mmu-mir-215
mmu-mir-871
mmu-mir-216b
mmu-mir-1192
mmu-mir-206
mmu-mir-720
mmu-mir-713
mmu-mir-207

MI0000390
MI0006291
MI0004650
MI0004662
MI0000730
MI0000716
MI0000717
MI0000150
MI0005550
MI0000547
MI0000576
MI0000147
MI0000554
MI0000548
MI0000229
MI0000607
MI0000700
MI0000701

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0000689
MI0005479
MI0004685
MI0004133

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0005004
MI0000221
MI0000588
MI0000407
MI0000151
MI0000684
MI0000587

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

MI0000722
MI0000156
MI0000152
MI0000169
MI0005478
MI0000725
MI0001642
MI0000235
MI0000144
MI0000172
MI0000146
MI0000621
MI0000699
MI0000821
MI0000630
MI0005495
MI0000603
MI0000695
MI0000646
MI0000795
MI0000632
MI0003493
MI0000159
MI0000820
MI0001151
MI0005552
MI0005484
MI0000731
MI0000741
MI0001146
MI0004295
MI0000715
MI0000161
MI0003484
MI0000974
MI0005471
MI0004126
MI0006297
MI0000249
MI0004678
MI0004698
MI0000250

miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK
miRBase_LINK

0
6
1
0
0
1
2
1
2
0
0
2
0
2
1
0
1
1
1
1
1
0
0
1
0
0
2
0
0
2
0
0
1
2
0
1
0
0
1
2
0
1
0
0
1
2
0
1
0
1
1
0
0
1
45,487
191,433
207,508
53,007
166,348
209,769
10,752
77,404
98,142
13,35982,94599,2291,551
2,466
21,502
2,364
3,736
21,904
230
718
156
332
1,377
159
45,632
194,924
210,330
53,221
169,668
214,907
83
383
315
125
526
326
57
128
505
118
111
524
30
19
1,432
41
23
1,488
22
19
1,392
34
23
1,458
30
3
77
38
6
81
195,450
19,65547,352
192,381
19,72549,959
46
243
85
46
114
90
0
0
15
0
2
16
149
1,253
987
220
993
1,060
25
3
75
32
6
81
18
1
1,077
55
3
1,222
54,9481,404 2,277,812
74,8132,390 2,626,307
27,49942,040142,351
29,023
28,914
164,768
15,968493
1,681
16,387
347
1,948
4,192
10,69272,514
6,653
16,382
84,101
21,491
29,102
18,384
21,36016,67921,32627,49641,808140,803
29,02028,764
163,598
24
7
6
43
3
7
7
0
6
23
1
7
4,735
34,984
61,132
6,012
27,52871,682
1,701
6,853
31,682
3,133
7,909
37,227527
4,783
34,032
739
6,085
40,619
8
37
48
14
49
58
1,654
5,705
27,2403,087
6,755
33,021
421
833
177
887
1,335
215
60
20,655
24,66955
13,99830,595
138,290 1,092,020 1,250,491
195,513 1,174,404 1,551,606
36,1172,616
40,84654,152
1,326
50,744275
3,886
10,906526
4,188
13,606
312
1,102
2,563
491
1,106
3,206
14
11
6
9
1
8
525
2
99
844
5
133
3
2
45
19
1
62
3
2
45
19
1
62
4,943
730
2,213
6,840
696
3,091
296
369
709
278
348
1,038
0
0
4
0
0
6
37,243
237,812234,91755,688
171,521366,144
202
830
660
238
935
1,106
1,715,391
31,64792,856 2,085,838
21,114
157,644
41,161
90
2,675
79,581
146
4,555
41,10689
2,673
79,491
146
4,553
12
4
122
19
6
211
11
0
1
35
1
2
168
120
2,000
265
111
4,108
5
6
7
8
0
15
5
21
2
1
13
5
3
1
3
0
0
9
0
0
1
0
0
3
3
0
1
3
0
4
1
0
1
2
0
4
6
1
5
21
0
24
32,484494
245
50,380
685
1,930
9
70
0
5
99
1
37
10
0
8
3
1
0
9
0
0
5
3
0
1
0
10
0
1
5
2
0
0
0
1
0
0
0
0
0
4
0
0
0
0
0
1

8
7
5
4
4
4
4
4
3
873,552
381,83153,523
2,972
888,682
1,758
1,443
3,033
2,948
235
524,522
624
33
4,662
222
2,376
5,037,674
434,595
36,824
194,534
128,342
431,48990
44
206,073
88,50586,785
214
77,462
3,868
90,032
5,402,324
185,801
33,387
8,780
49
1,608
132
132
18,5133,038
10
1,103,325
3,971
4,104,490
128,208
128,058
374
50
6,772
41
47
16
4
11
8
57
86,218
184
59
17
12
8
4
1

#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
0.000
0.000
0.000
#DIV/0!
0.858
0.805
0.656
0.693
0.857
0.664
0.483
0.732
0.647
0.789
1.016
1.000
#DIV/0!
0.677
0.781
0.327
0.734
0.947
0.974
0.630
1.006
0.947
0.558
0.304
0.788
0.543
0.713
0.571
0.536
0.475
1.091
0.707
0.667
0.523
0.635
1.556
0.622
0.158
0.158
0.723
1.065
#DIV/0!
0.669
0.849
0.822
0.517
0.517
0.632
0.314
0.634
0.625
5.000
#DIV/0!
#DIV/0!
1.000
0.500
0.286
0.645
1.800
4.625
#DIV/0!
0.000#DIV/0!
#DIV/0!
#DIV/0!

#DIV/0!
#DIV/0!
2.000#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
1.151
0.933
0.660
0.521
1.149
0.728
1.153
0.826
0.826
0.500
0.996
2.132
0.000
1.262
0.500
0.333
0.587
1.454
1.421
0.653
1.745
1.453
2.333
0.000
1.271
0.866
0.786
0.755
0.845
0.624
1.476
0.930
1.973
0.928
0.996
11.000
0.400
2.000
2.000
1.049
1.060
#DIV/0!
1.386
0.888
1.499
0.616
0.610
0.667
0.000
1.081
#DIV/0!
1.615#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!
0.721
0.707
3.333
1.800
#DIV/0!
#DIV/0!
#DIV/0!
#DIV/0!

1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
1.000
0.989
0.989
0.982
0.981
0.979
0.966
0.964
0.962
0.955
0.951
0.948
0.944
0.938
0.931
0.926
0.881
0.867
0.864
0.863
0.862
0.862
0.861
0.857
0.857
0.853
0.851
0.838
0.828
0.825
0.823
0.806
0.806
0.805
0.802
0.799
0.750
0.744
0.726
0.726
0.716
0.683
0.667
0.642
0.597
0.589
0.587
0.587
0.578
0.500
0.487
0.467
0.400
0.333
0.333
0.250
0.250
0.208
0.127
0.000
0.000
0.000
0.000
0.000
0.000
0.000

Supplementary Table 3. The comparison of global mRNA expression in Mir221/222AdipoKO and Mir221/222flox/y mice fed with standard (STD) chow.
m
Test

m
O

Controlm
Feature ID
Probe Set IDExpression value
Expression{STD AdipoKO
value
Ratio{STD387}
flox/yLog2Ratio
378}
category
解析対象 Flag
17211066 12.07175 12.77533 0.9449267 -0.081726
0 main17211305 39.99381 41.28632 0.968694 -0.045887
0 main17211548 28.72986 30.91425 0.9293404 -0.105721
0 main17212947 66.01734 73.47573 0.8984918 -0.154423
0 main17214841 450.3722 594.9557 0.7569844 -0.401664
0 main17215565 89.13591 94.91344 0.9391284 -0.090606
0 main17216888 23.89316 26.84098 0.8901747-0.16784
0 main17217291 48.53498 42.96968 1.1295169 0.1757059
0 main17217854
90.1264 97.81096 0.9214346 -0.118046
0 main17217901 205.3408
238.968 0.8592816 -0.218797
0 main17220177 28.33733 38.15434 0.7427027 -0.429143
0 main17220373 223.2658 264.4885 0.8441418 -0.244443
0 main17220489 337.2852 305.6174 1.1036191 0.1422423
0 main17221158 18.37664 18.73044 0.981111 -0.027512
0 main17222440 160.8323 235.9621 0.6816023 -0.552998
0 main17223138 87.21326 102.9134 0.8474432 -0.238811
0 main17223946 17.66826
16.0907 1.0980417 0.1349329
0 main17225373 38.80965 27.58103 1.4071139 0.4927391
0 main17228426 344.0268 377.0215 0.9124859 -0.132126
0 main17229178 183.1643 249.8483 0.733102 -0.447914
0 main17230469 56.31487 54.15099 1.0399601 0.0565282
0 main17230602 200.0101 210.6942 0.949291 -0.075078
0 main17230668 296.3055 311.7881 0.9503426-0.07348
0 main17230760 72.25445 85.06554 0.8493974 -0.235488
0 main17231461 203.3791 203.6139 0.9988468 -0.001665
0 main17232483 13.10851 13.23052 0.9907781 -0.013366
0 main17232734 146.1333 158.2847 0.9232307 -0.115237
0 main17233437 198.2301
215.519 0.9197802 -0.120639
0 main17233457 855.5234 1143.976 0.7478508 -0.419178
0 main17235211232.281 400.6118 0.5798157 -0.786334
0 main17236182 1467.903 1672.027 0.8779182 -0.187842
0 main17236439 15.10888 15.49385 0.9751534 -0.036299
0 main17238449 200.7531 198.2105 1.0128278 0.0183889
0 main17238571 267.1325 268.5456 0.994738 -0.007612
0 main17239234 28.48119 24.57605 1.1589002 0.2127564
0 main17240123
11.9302 11.32564 1.0533798 0.0750257
0 main17240226 245.2886 234.4308 1.0463156 0.0653181
0 main17241032 482.7296 187.1108 2.5799131 1.3673225
0 main17243509 141.4882 139.9786 1.0107845 0.0154755
0 main17245095 357.7865 384.7924 0.929817 -0.104981
0 main17245188 316.8773 293.1326 1.0810033 0.1123709
0 main17245587
437.382 454.9009 0.9614885 -0.056658
0 main17246268 56.10082 51.18897 1.0959552 0.1321889
0 main17247448 279.4539 315.9281 0.884549 -0.176986
0 main17247519 152.9826
168.062 0.9102748 -0.135626
0 main17247533 1104.707 1084.556
1.01858 0.0265592
0 main17247550
335.193 423.2663 0.7919199 -0.336574
0 main17248213 497.7278 864.8309 0.5755204 -0.797061
0 main17248288
106.309 143.4328 0.7411764 -0.432111
0 main17248476 946.3215
939.384 1.0073852 0.0106154
0 main17253307 200.6664 296.9527 0.6757521 -0.565434
0 main17254933 336.5393 393.6081 0.8550111 -0.225985
0 main17255443 224.2298 225.9709 0.992295 -0.011159
0 main17255727
63.1117 61.25826 1.0302562 0.0430031
0 main17255775 94.62283 106.8942 0.8852008 -0.175923
0 main17255828 156.4574 181.5189 0.8619345-0.21435
0 main17256991 41.62211
38.2034 1.0894871 0.1236491
0 main17257235 120.8629 120.3888 1.0039381 0.0056703
0 main17257801 83.89841 65.87026 1.2736918 0.3490162
0 main17258789 189.1216 226.4071 0.8353166 -0.259605
0 main17261289 51.45292 45.55436 1.129484 0.1756638
0 main17261896 27.95826
24.7414 1.1300193 0.1763474
0 main17262055 57.27368 56.09911 1.0209374 0.0298944
0 main17262964 29.18693 28.15368 1.0367004 0.051999
0 main17266264 685.7847 808.1497 0.8485862 -0.236867
0 main17266498 277.0902 313.5163 0.8838143 -0.178185
0 main17266534 125.6685 102.0037 1.2319994 0.3010016
0 main17267632 101.8389 105.6088 0.9643032 -0.052441
0 main17270621
274.41 276.8301 0.9912578 -0.012668
0 main17272095 85.95374
96.8969 0.8870639-0.17289
0 main17272530 1212.562 1443.771 0.8398576 -0.251783
0 main17273819 271.2213 307.9908 0.8806149 -0.183417
0 main17277017 40.16175
37.5067 1.0707887 0.0986738
0 main17277177 50.57738 48.52398 1.0423172 0.0597944
0 main17277387 96.99457 250.5789 0.387082 -1.369289
0 main17277521 61.92524 58.45456 1.059374 0.083212
0 main17279210 384.4613 385.0033 0.9985922 -0.002032
0 main17280913 217.6443 167.5096 1.2992945 0.3777285
0 main17281228 370.9284 432.9735
0.8567 -0.223138
0 main17284839 53.44313 54.55101 0.9796909 -0.029601
0 main17286595 478.4573 444.4544 1.0765048 0.1063548
0 main17286962 353.1282 611.6155 0.5773696 -0.792433
0 main17286998 34.79554 32.43024 1.072935 0.1015627
0 main17287144 42.57329 46.63666 0.9128718 -0.131516
0 main17289196 81.04126 62.01216 1.3068608 0.3861055
0 main
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m

2Up
2Down

Ratio flag

2Up

2Down

≧
≧
≦
≧

KeywordGene Accession
Gene SymbolGene Description
mRNA Accession
mRNA Source
mRna - Description
mRNA - xhybEntrezGene ID
UniGene ID SwissProt accession
ChromosomeGO BiologicalGO
Process
Biological
IDGO
Process
CellularTerm
Component
GO Cellular ID
Component
GO MolecularTerm
GO
Function
Molecular
IDmiR221/222
Function Termtarget gene
NM_177722 Mcmdc2
minichromosome
NM_177722
maintenance
RefSeqdomainMuscontaining
musculus
2 FALSEminichromosome
240697maintenance
Mm.259800
domainE9Q956containing
chr1
2 (Mcmdc2),
GO:0006260
mRNA. DNA// GO:0008150
replication
GO:0005575// biological_process
cellular_component
GO:0003677DNA// GO:0005524
binding○// ATP// GO:0003674
binding // molecular_function
NM_053191 Pi15
peptidase inhibitor
NM_053191
15
RefSeq
Mus musculus FALSE
peptidase inhibitor
94227
15 (Pi15),
Mm.442452
mRNA.
Q8BS03chr1
GO:0010466negative regulation
GO:0005576
of peptidase
extracellular
activity
GO:0030414
regionpeptidase inhibitor○
activity
NM_133235 Khdrbs2
KH domain containing,
NM_133235
RNA
RefSeqbinding, signal
Mus musculus
transduction
FALSE
KH domain
associatedcontaining,
170771
2
Mm.336594
RNA binding,
Q9WU01signal transduction
chr1
associated
GO:0006351
2 (Khdrbs2),
transcription,// GO:0006355
mRNA.
GO:0005634
DNA-templated// GO:0009967
nucleus// GO:0005634// regulation// nucleus
GO:0003723
of transcription,
RNA// GO:0005070
binding
DNA-templated○// SH3/SH2// GO:0008143//adaptor
positiveactivity//regulation
GO:0008266// poly(A)of signa// bG
NM_001164566
Spats2l
spermatogenesis
NM_001164566
associated,
RefSeqserine-richMus
2-likemusculus FALSE
spermatogenesis
67198
associated,
Mm.159989
serine-rich
Q91WJ72-like (Spats2l),
chr1transcript
GO:0008150
variantbiological_process
2, mRNA. GO:0005634nucleus// GO:0005730// nucleolus
GO:0044822// GO:0005737// cytoplasm
poly(A) RNA////GO:0043234
protein○bindingcomplex// GO:0005634// nucleus // //nucleolus
GO:0005
NM_010472 Agfg1
ArfGAP withNM_010472
FG repeats 1
RefSeq
Mus musculus FALSE
ArfGAP with FG
15463
repeats
Mm.433409
1 (Agfg1),Q8K2K6
mRNA.
chr1
GO:0001675acrosome// GO:0006810
assembly
GO:0005634// GO:0007275// transport
nucleus// GO:0016023////multicellularcytoplasmic
GO:0007283
GO:0003677// GO:0031410
organismal
membrane-bounded
DNA////GO:0007289
GO:0008060
binding//development
GO:0042995○// ARF////GO:0030154
vesicleGO:0008270
GTPase// spermatogenesis// //GO:0043025
cytoplasmic
activator////GO:0032312
GO:0046872
activity//
vesicle//GO:0043
sperma
// //
zinc
//Gc
NM_133816 Sh3bp4
SH3-domainNM_133816
binding protein
RefSeq4
Mus musculus FALSE
SH3-domain binding
98402 protein
Mm.170983
4 (Sh3bp4),
Q921I6
mRNA.chr1
GO:0006897endocytosis// GO:0008285
GO:0005634// negative// GO:0010508
regulation
nucleus// GO:0005737//ofcytoplasm
GO:0030308
cell
GO:0005092
proliferation// GO:0005905// coated
GDP-dissociation////GO:0032007//
GO:0017016
positive
pit ////GO:0016020○
membraneregulation//inhibitor//GO:0034260
GO:0042802
of////activity
cytoplasmic
autophagy
GO:0031410//////GO:0050790
GO:0005092
Ras//vesicle
negative
GTPase// GO:0070// regu
extra
//bin
//GG
NM_172485 Thsd7b
thrombospondin,
NM_172485
type I, domain
RefSeqcontaining
Mus musculus
7B
FALSE
thrombospondin,
210417type I,Mm.380518
domain containing
Q6P4U07B (Thsd7b),
chr1
mRNA.
GO:0008150biological_process
GO:0016020membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_001160268
Plekha6
pleckstrin homology
NM_001160268
domainRefSeqcontaining,Musfamilymusculus
A member
FALSE
pleckstrin
6
homology
240753domain
Mm.253559
containing,
Q7TQG1
family Achr1
member 6 (Plekha6),
GO:0008150
transcript
biological_process
variant
GO:0005575
2, mRNA.cellular_component
GO:0003674molecular_function○
ENSMUST00000070283
Dennd1b
DENN/MADDENSMUST00000070283
domain containing
ENSEMBL
1B havana:known FALSE
chromosome:GRCm38:1:138963436:139063719:1
329260 Mm.337604 Q3U1T9// Mm.475093
chr1//gene:ENSMUSG00000056268
Mm.394252
GO:0006810// Mm.474921
transport// GO:0015031//
gene_biotype:protein_coding
proteinGO:0005737// transport
GO:0032313
cytoplasm// GO:0031410// regulation// GO:0008150//GO:0005085
cytoplasmictranscript_biotype:protein_coding
of//Rab
GO:0005575
GTPaseguanyl-nucleotide//vesicle//GO:0032851
GO:0017112
activity// cellular_component
GO:0005829○ //////
exchange
biological_process
GO:0043547
GO:0017112// GO:0030136
factor////cytosol//
activity
GO:0032851
GO:0017112// positive////clathrin-c
Rabregulagua
NM_172643 Zbtb41
zinc finger and
NM_172643
BTB domain
RefSeqcontainingMus
41 musculus
homolog FALSE
zinc finger and226470
BTB domain
Mm.119711
containing
Q811F1
41 homolog
chr1(Zbtb41),GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
ENSMUST00000181811
Gm17275 predicted gene,
ENSMUST00000181811
17275 ENSEMBL ensembl_lincrna:known
FALSE chromosome:GRCm38:1:180802568:180809483:1--Mm.322735 P84244// Mm.427935
chr1
GO:0006334
gene:ENSMUSG00000097347
nucleosome// GO:0007420
GO:0000786
assembly// gene_biotype:lincRNA
GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus
transcript_biotype:lincRNA// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
NM_173378 Trp53bp2 transformation
NM_173378
related protein
RefSeq53 binding
Musprotein
musculus
2 FALSEtransformation209456
related protein
Mm.287450
53 binding
Q8CG79proteinchr1
2 (Trp53bp2),
GO:0006915
mRNA. apoptotic// GO:0007049
process
GO:0005634////GO:0007417
cell cycle
nucleus// GO:0005737// central// cytoplasm
GO:0007507
GO:0008134
nervous// GO:0048471// system
perinuclear
transcription////GO:0009792
GO:0017124
development// region
GO:0005634○
factor//of//GO:0010212
binding
GO:0042802
cytoplasm// heart// GO:0005634//development
SH3////nucleus//domain
GO:0045786
GO:0051059////
binding
GO:0005
embryonucleus////G//Gd
NM_001163754
Rab3gap2 RAB3 GTPase
NM_001163754
activatingRefSeq
protein subunit
Mus2 musculus FALSE
RAB3 GTPase98732
activating
Mm.275841
protein subunit
Q8BMG72 (Rab3gap2),
chr1
mRNA.
GO:0043087regulation// GO:0008150
of GO:0005737
GTPase// GO:0043087
activitycytoplasm// GO:0005886// biological_process// GO:0043087//GO:0005096
plasma// GO:0005737
membrane
GTPase//////GO:0043547
regulation
GO:0030234//activator//cytoplasm
GO:0005886○of GTPase
activity// GO:0046982// plasma
activity// enzyme
membrane////regulation
GO:0003674
regulator of
activity
GTPa// G
NM_001290397
Mybl1
myeloblastosis
NM_001290397
oncogene-like
RefSeq1
Mus musculus FALSE
myeloblastosis 17864
oncogene-like
Mm.4791 (Mybl1),
P51960transcript
chr1
variant 2, GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated
nucleus// regulation
GO:0003677
of transcription,
DNA// GO:0003682
binding
DNA-templated○// chromatin binding
NM_019570 Rev1
REV1 homolog
NM_019570(S. cerevisiae)
RefSeq
Mus musculus FALSE
REV1 homolog56210(S. cerevisiae)
Mm.389103(Rev1),
Q920Q2
mRNA. chr1
GO:0006260DNA// GO:0006281
replication
GO:0005634////DNA
GO:0006974
repairnucleus// cellular// GO:0009411
GO:0000287
responsemagnesium//
to//GO:0042276
DNA
GO:0003677
damageion○ binding//stimulus//GO:0006261
GO:0003684// DNA// response
binding////GO:0009411
GO:0003720
to //UV
damaged// error-p// G
D
NM_001163314
Pgap1
post-GPI attachment
NM_001163314
to proteins
RefSeq1
Mus musculus FALSE
post-GPI attachment
241062 toMm.103539
proteins 1 (Pgap1),
Q3UUQ7mRNA.
chr1
GO:0006505GPI// GO:0006506
anchor metabolic
GO:0005783// GO:0006810
process
endoplasmic// GO:0016020// GPI// GO:0006886
GO:0004518
anchorreticulum// GO:0016021
biosynthetic//nuclease//membrane//GO:0007605
GO:0016787
process//activity
GO:0005783○// integral//////GO:0009880
transporthydrolase
GO:0016788
component// GO:0005783//activity
intracellular////of
GO:0009880
GO:0042578
membrane// hydrolase//protein
GO:0005////act
//
tra
en
GG
NM_010154 Erbb4
v-erb-a erythroblastic
NM_010154
leukemia
RefSeqviral oncogene
Mus musculus
homolog
FALSE
v-erb-a4 (avian)erythroblastic
13869 leukemia
Mm.442420
viralQ61527
oncogene homolog
chr1
4 (avian)
GO:0001755(Erbb4),neuralmRNA.
// GO:0006351
crest cell
GO:0005634
migration// GO:0006355
nucleus// GO:0005737
transcription,// cytoplasm
GO:0006468
GO:0000166
DNA-templated// GO:0005739// mitochondrion
nucleotide////GO:0006915
GO:0004672// binding
regulation
GO:0005886○ // //plasma//GO:0007165//GO:0004713
proteinof transcription,
membrane// GO:0005901
kinase////GO:0007169
activity
GO:0004714//DNA-templated
caveola// GO:0014// protein// //pos//GG
NM_010262 Gbx2
gastrulation brain
NM_010262
homeobox
RefSeq2
Mus musculus FALSE
gastrulation brain
14472
homeobox
Mm.204730
2 (Gbx2),
P48031
mRNA. chr1
GO:0001569patterning// GO:0001569
of GO:0005634
blood//vessels
GO:0001755
nucleus// patterning// GO:0006351
GO:0003677
of blood vessels
DNA////GO:0006355
GO:0003700
binding// neural○// crest
sequence-specific////GO:0007411
GO:0043565
cell migration// DNA
GO:0008283// transcription,binding trans// G
D
NM_001039184
Cep350centrosomal NM_001039184
protein 350 RefSeq
Mus musculus FALSE
centrosomal protein
74081350
Mm.260247(Cep350), D3YTP2
mRNA.
chr1
GO:0008150biological_process// GO:0034453
GO:0005634// microtubule
nucleus// GO:0005737
anchoring// cytoplasm
GO:0003674// GO:0005813// centrosome
molecular_function// GO:0008017// GO:0005634○// nucleus// microtubule// cytoplasm// GO:0005737
binding// centrosome// GO:0005
NM_009721 Atp1b1
ATPase, Na+/K+
NM_009721
transporting,
RefSeqbeta 1 Mus
polypeptide
musculus FALSE
ATPase, Na+/K+
11931
transporting,Mm.4550
betaP14094
1 polypeptide
chr1(Atp1b1), mRNA.
GO:0001666response// GO:0001824
to hypoxia
GO:0005886// GO:0006200// blastocyst
plasma// GO:0005890
membranedevelopment// GO:0006810
GO:0005391// //GO:0005901
sodium:potassium-exchanging// ATPsodium:potassium-exchanging////GO:0006811
GO:0005515
catabolic// GO:0016020○process////GO:0006813
GO:0023026// transport// GO:0016021
ATPaseATPase////GO:0006814//GO:0005391
complexionactivity
transport// GO:0016// //caveo
//pro
//G
ENSMUST00000159685
Gm12657 //predicted
Gm6749// ENSMUST00000159685
gene// ENSMUST00000159685
H3f3c
12657
// Gm10257// predicted
ENSEMBL// ENSMUST00000159685// pseudogene
H3f3bhavana:known// H3f3a
6749FALSE
chromosome:GRCm38:1:180810241:180813603:-1// H3 //histone,
ENSMUST00000159685
667250family 3C
Mm.449778// predicted
E0CYN1//// Mm.371797
ENSMUST00000159685
gene 10257
chr1//gene:ENSMUSG00000060743
H3
Mm.371563
histone,GO:0001649//family//ENSMUST00000159685
Mm.315189
3B
osteoblast////GO:0042692
H3 histone,// differentiation
gene_biotype:protein_coding
Mm.375617
GO:0000228
family// GO:1902340
3A//nuclear//Mm.385440//muscle
GO:0000788
chromosome//cell
GO:0006997
GO:0000979
differentiation//transcript_biotype:protein_coding
Mm.427935// GO:0001740// nuclear
RNA////GO:0090230//
GO:0000980//polymerase
negative
Mm.454661
nucleosome// GO:0005634○regulation//II//GO:0006334
core
GO:0031492// Mm.491100
Barr
promoterof// body
chromosome
GO:0043234////sequence-specific//GO:0007420
nucleus//GO:0003677
Mm.491524
condensatio// GO:0070// protein////GDG
NM_175127 Fbxo28
F-box proteinNM_175127
28
RefSeq
Mus musculus FALSE
F-box protein 28
67948(Fbxo28),
Mm.30737
mRNA. Q8BIG4
chr1
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_177389 Mia3
melanoma inhibitory
NM_177389
activity
RefSeq3
Mus musculus FALSE
melanoma inhibitory
338366activity
Mm.41152
3 (Mia3),
Q8BI84
mRNA. chr1
GO:0002063chondrocyte// GO:0002687
GO:0005783
development// GO:0006810
endoplasmic// GO:0005789
positive// GO:0006887
regulation
GO:0003674
reticulum// GO:0005789
of//leukocyte
molecular_function//endoplasmic
GO:0007162//migration
GO:0016020○reticulum// GO:0015031// transport
membrane// GO:0016021//// exocytosis
GO:0016192// endoplasmic// GO:0005// negat// reG
NM_145515 Mark1
MAP/microtubule
NM_145515
affinity-regulating
RefSeq kinase
Mus musculus
1
FALSE
MAP/microtubule
226778affinity-regulating
Mm.7445 Q8VHJ5
kinase 1 (Mark1),
chr1 mRNA.GO:0000226microtubule// GO:0001764
cytoskeleton
GO:0005737// GO:0006468
cytoplasm
organization// GO:0005856// GO:0007010//GO:0000166
cytoskeleton// neuron// GO:0005886
migration
nucleotide//////GO:0016055
GO:0000287
plasma//// protein
binding
GO:0016020
membrane○ ////
phosphorylation
GO:0016310//GO:0001786
magnesium// //membrane
GO:0005737
//ion
////
GO:0035556
GO:0004672
cytoskeletonbinding// cytoplasm// GO:0005// phosp
//org
//G
//G
NM_007956 Esr1
estrogen receptor
NM_007956
1 (alpha)
RefSeq
Mus musculus FALSE
estrogen receptor13982
1 (alpha)
Mm.9213(Esr1),// mRNA.
P19785
Mm.463262 chr10// Mm.489063
GO:0001547antral// GO:0002064
ovarianGO:0005634
follicle// GO:0006351
growthnucleus// GO:0005634// epithelial// nucleus
GO:0006355
GO:0001046
cell//development
GO:0005737// cytoplasm
core////GO:0006357
GO:0003677
promoter////transcription,cytoplasm
GO:0005737○sequence-specific////GO:0006366
GO:0003682// DNA-templated
mitochondrion// GO:0005739
DNA////GO:0007200
GO:0003700
binding////Golgi//regulation
GO:0005//apparDNA////GG
XR_380237 LOC102632938
uncharacterized
XR_380237
LOC102632938
RefSeq
PREDICTED: Mus
FALSE
musculus
102632938
uncharacterized--LOC102632938
Q8BG92
chr10(LOC102632938),--ncRNA.
----------○
NM_001168304
Cdk19
cyclin-dependent
NM_001168304
kinase 19
RefSeq
Mus musculus FALSE
cyclin-dependent
78334
kinaseMm.200924
19 (Cdk19),
Q8BWD8transcript variant
chr10 1, mRNA.
GO:0006468protein// GO:0007049
phosphorylation
GO:0005575// GO:0016310//cellular_component
cell cycle// GO:0051301//GO:0000166
phosphorylation
nucleotide////GO:0051726
GO:0004672// cellbinding
division○ ////GO:0008152//GO:0004674//protein
regulation
kinaseof//cell
activity
GO:0004693
cycle// //protein
metab
// G
NM_001193303
Lims1
LIM and senescent
NM_001193303
cell antigen-like
RefSeq domains
Mus musculus
1
FALSE
LIM and senescent
110829cellMm.57734
antigen-likeQ99JW4
domains 1 (Lims1),
chr10 transcript
GO:0007160
variant cell-matrix
3,//mRNA.
GO:0007163
adhesion
GO:0005886// GO:0016337// establishment
plasma// GO:0005925
membrane// GO:0043009
GO:0005515
or maintenance// //GO:0005925
focal
protein////adhesion
GO:0043066
of
GO:0008270
cellbinding//polarity
GO:0016020//○focal//////
zinc//GO:0045216
adhesion
GO:0046872
singleion//bindingorganismal
GO:0030054// membrane//////
GO:0045892
GO:0008270
metal
cell-cell//ion
GO:0043// celladhesibinding//jun
G
NM_011240 Ranbp2
RAN bindingNM_011240
protein 2 RefSeq
Mus musculus FALSE
RAN binding protein
193862 Mm.431695(Ranbp2), mRNA.
Q9ERU9chr10
GO:0006457protein// GO:0006810
folding
GO:0005634// transport// GO:0015031
nucleus//// GO:0005643
protein// nuclear
GO:0033132
transport
GO:0003723//pore
GO:0005739// negative//RNA//mitochondrion//GO:0046907
GO:0003755
binding
regulation// GO:0016020○// peptidyl-prolyl//////
of
GO:0051028
membrane
GO:0005515
glucokinase// GO:0031965
cis-trans// activity//
nuclear//GO:0090526
GO:0008270
isomerase
membrane//// intracellula
GO:0031//act//GG
NM_021565 Midnmidnolin
NM_021565 RefSeq
Mus musculus FALSE
midnolin (Midn),
59090
mRNA.
Mm.143813 Q3TPJ7
chr10
GO:0033132negative// GO:0046676
regulation
GO:0005634//of
GO:0033132
glucokinase
nucleus// GO:0005730//
activity
nucleolus
GO:0046676
GO:0019900////negative
GO:0005730// nucleolus
kinase// regulation
GO:0019900
binding//// GO:0005829
cytosol○of //insulin
kinase// nucleus
secretionbinding// GO:0005634// nucleolus// negative// GO:0005
regulatio
NM_011595 Timp3
tissue inhibitor
NM_011595
of metalloproteinase
RefSeq 3 Mus musculus FALSE
tissue inhibitor 21859
of metalloproteinase
Mm.4871 P39876
3 (Timp3), mRNA.
chr10
GO:0010466negative// GO:0045861
regulation
GO:0005576//of
GO:0051045
peptidase
extracellular// GO:0005578
activity// GO:0071310
GO:0004857
region// negative// //GO:0005604
proteinaceous
enzyme//regulation//GO:0010951
GO:0008191
inhibitor// GO:0005634
extracellularof○proteolysis//activity//GO:0051045
GO:0030414
matrix////// metalloendopeptidase
GO:0005737
negative// basement// GO:0046872
regulation// GO:0031
membranof inhimem
NM_001128086
Anks1bankyrin repeat
NM_001128086
and sterileRefSeq
alpha motif domain
Mus musculus
containing
FALSE
ankyrin
1B repeat and77531
sterileMm.440605
alpha motif
Q8BIZ1domain containing
chr10 1B (Anks1b),
GO:0008150
transcript
biological_process
variant
GO:0005634
1, mRNA. nucleus// GO:0005737// cytoplasm
GO:0046875// GO:0005886// plasma
ephrin// GO:0046875
receptor
membrane// GO:0016020○ binding// membrane////ephrin
GO:0030054
receptor// cell junction
binding// GO:0042// ce
NM_172790 Ankrd52
ankyrin repeat
NM_172790
domain 52RefSeq
Mus musculus FALSE
ankyrin repeat237615
domain Mm.440177
52 (Ankrd52),
Q8BTI7
mRNA. chr10
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_028873 Dnajc14
DnaJ (Hsp40)
NM_028873
homolog, subfamily
RefSeq C, member
Mus musculus
14 FALSE
DnaJ (Hsp40) homolog,
74330 Mm.296915
subfamily C,
Q921R4member 14
chr10(Dnajc14),GO:0006810
mRNA.
transport// GO:0015031// protein
GO:0005783// transport
GO:0008150
endoplasmic// GO:0016020// biological_process
GO:0001664
reticulum// GO:0016021//G-protein
membrane// GO:0050780//coupled
GO:0005789○// integral
receptor
componentbinding of//membrane
dopamine recep// en
NM_001114333
Grm1
glutamate receptor,
NM_001114333
metabotropic
RefSeq 1 Mus musculus FALSE
glutamate receptor,
14816metabotropic
Mm.4829861P97772(Grm1), transcript
chr10 variantGO:0000186
2, mRNA. activation// GO:0000187
of MAPKK
GO:0005634// GO:0007165
activity
nucleus// GO:0005886// activation// plasma
GO:0007186
GO:0001639
of//membrane
MAPK
GO:0005887
PLC//activity//GO:0007205
GO:0004871
activating// integral// GO:0014069
signal
○ G-protein
component//transduction//GO:0007206
GO:0004930
coupled// GO:0014069
of plasma// //G-protein
glutamate//GO:0007216
GO:0005515
membrane// coupled
GO:0016
receptor//////GrepG
XM_006512693
Clvs2
clavesin 2 XM_006512693
RefSeq
PREDICTED: Mus
FALSE
musculus215890
clavesinMm.94461
2 (Clvs2), transcript
Q8BG92variant
chr10
X1, mRNA.
GO:0006810transport// GO:0007040// lysosome
GO:0005622// GO:0007040
organization
intracellular// GO:0005768// lysosome
GO:0005215// endosome// GO:0005794
organizationtransporter//// Golgi
GO:0008289
apparatus// GO:0005802
activity○ // //GO:0080025//lipidtrans-Golgi//binding
GO:0016020
network//// GO:0080025
phosphatidylinos////GO:0030
membra// G
NM_008538 Marcks
myristoylatedNM_008538
alanine richRefSeq
protein kinaseMus
C musculus
substrate FALSE
myristoylated alanine
17118 rich
Mm.30059
protein kinase
P26645
C substratechr10(Marcks),--- mRNA. --GO:0005737cytoplasm// GO:0005813//GO:0003779
centrosome// GO:0005856
actin//// cytoskeleton
GO:0005080
binding// GO:0005938○// protein////cell
GO:0005515
cortexkinase// GO:0016020//
C membranebinding// GO:0005516//// protein
GO:0042// germin
bin
NM_029083 Ddit4
DNA-damage-inducible
NM_029083transcript
RefSeq 4 Mus musculus FALSE
DNA-damage-inducible
74747 Mm.21697
transcript 4Q9D3F7(Ddit4), mRNA.
chr10
GO:0001666response// GO:0001666
to hypoxia
GO:0005622// GO:0001764// response
intracellular// GO:0005622
to//hypoxia
GO:0006915
GO:0071889// intracellular////GO:0005737
neuron14-3-3// //GO:0007420
migrationcytoplasm
protein// GO:0005739○//binding//
apoptotic//mitochondrion
GO:0008283//
process
GO:0005622//// //GO:0009968
intracellular
brain //developme
GO:0005////cytG
NM_010914 Nfyb
nuclear transcription
NM_010914
factor-Y
RefSeqbeta
Mus musculus FALSE
nuclear transcription
18045factor-Y
Mm.245998
beta (Nfyb),
P63139mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005622
DNA-templated// GO:0045893
intracellular// GO:0005634// regulation// GO:0006355
GO:0003677// nucleusof// GO:0005634
transcription,//DNA
nucleus// GO:0003677
binding
DNA-templated//// GO:0005667
transcription○// DNA// GO:0003700
bindingfactor//// positive
GO:0016602//complex
sequence-specific//regulation
GO:0032403////CCAAT-bin
GO:0005of trans//
DN
G
NM_001037848
Cnot2
CCR4-NOT transcription
NM_001037848
RefSeqcomplex, subunit
Mus musculus
2
FALSE
CCR4-NOT transcription
72068 Mm.351553
complex, subunit
Q8C5L32 (Cnot2),
chr10 transcript
GO:0000122
variant 4,negativemRNA.
// GO:0001829
regulation
GO:0005634//of
GO:0006351
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0006355
GO:0001226
RNA// GO:0030014
polymerase// CCR4-NOT
RNA////GO:0006417
GO:0004535
polymerase
II //promoter
GO:0005737
complex○ //II//GO:0007275//
transcription
GO:0001226//
trophectodermal
cytoplasm// GO:0005737
corepressor//////
GO:0010606
GO:0001226
cytoplasm
cell //differentiati
GO:0030
binding////CC//GG
NM_177798 Frs2
fibroblast growth
NM_177798
factor receptor
RefSeqsubstrate
Mus2musculus FALSE
fibroblast growth327826factorMm.135965
receptor substrate
Q8C1802 (Frs2),
chr10
mRNA. GO:0000187activation// GO:0001702
of MAPK
GO:0005737// activity
GO:0001759
cytoplasm////GO:0005886
gastrulation// GO:0002088//GO:0005068
plasmawith// GO:0005911
membranemouthtransmembrane////GO:0003281
forming
GO:0005104////cell-cell
GO:0016020
second○ receptor////junction
GO:0007169
GO:0005158// organ
protein//induction
membranetyrosine////GO:0007405
GO:0005168// kinaselens develop
adapt////GG
NM_001163024
Mon2
MON2 homolog
NM_001163024(yeast) RefSeq
Mus musculus FALSE
MON2 homolog67074(yeast)Mm.169924(Mon2), transcript
Q80TL7variant
chr10
1, mRNA. GO:0006810transport// GO:0015031// protein
GO:0005802// transport
GO:0016192
trans-Golgi// GO:0005802// vesicle-mediated// GO:0030036
network
GO:0005086// trans-Golgi
transport
ARF////GO:0043087
GO:0005086
guanyl-nucleotide//networkactin○ cytoskeleton// GO:0006895
exchangeorganization//factor
GO:0016192
activity// regulatio// //ARG
NM_011772 Ikzf4
IKAROS family
NM_011772
zinc fingerRefSeq
4
Mus musculus FALSE
IKAROS family22781
zinc finger
Mm.358648
4 (Ikzf4),Q8C208
mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// regulation// GO:0045944
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0005515// DNA// negative
binding// regulation
GO:0042803// protein ofbinding
tran// G
ENSMUST00000154425
Ppp3r1protein phosphatase
ENSMUST00000154425
3, regulatory
ENSEMBL
subunithavana:known
B, alpha isoform
FALSE
chromosome:GRCm38:11:17192844:17195109:1(calcineurin
19058
B, typeMm.41840
I)//Q63810
Mm.401506chr11//gene:ENSMUSG00000033953
Mm.474050
GO:0001569patterning// GO:0001837
gene_biotype:protein_codingof GO:0005622
blood//vessels
GO:0006470
intracellular////GO:0005623
epithelial// GO:0006470
GO:0004721//transcript_biotype:processed_transcripttocellmesenchymal// //GO:0005737
cytoplasm
phosphoprotein////GO:0007507
GO:0004721
transition// //plasma
GO:0005886○ phosphatase////membrane//protein
GO:0034504
GO:0005509//dephosphorylation
GO:0016020
activity// membrane////GO:0051531
GO:0005515// phosphoprote// GO:0042// //sarcole
protein////GG
NM_033523 Spred2
sprouty-related,
NM_033523
EVH1 domain
RefSeqcontaining
Mus2musculus FALSE
sprouty-related,
114716
EVH1 Mm.266627
domain containing
Q924S72 (Spred2),
chr11 mRNA.GO:0000188inactivation// GO:0007275
of
GO:0005634
MAPK// GO:0009966
activity
nucleus// GO:0005737// multicellular// cytoplasm
GO:0010801
GO:0005173//organismal
GO:0005886// plasma
stem////GO:0010801
GO:0005515
celldevelopment
membrane//factor
GO:0016020○ receptor////GO:0043517////
GO:0019901
membraneregulation
binding// GO:0031410
of//////signal
GO:0071901
proteincytoplasmic
GO:0019901
transduction//binding
GO:0005vesic//////GG
ENSMUST00000132285
Rab1
RAB1, member
ENSMUST00000132285
RAS oncogene
ENSEMBLfamilyhavana:known FALSE
chromosome:GRCm38:11:20201439:20219487:1
19324 Mm.271944 P62821// Mm.368433
chr11
gene:ENSMUSG00000020149// Mm.471872
GO:0000045// Mm.486775
autophagic// GO:0006184
gene_biotype:protein_coding// Mm.491009
vacuoleGO:0000139// assembly
GO:0006810
Golgi// GO:0005622//membrane
GTP// GO:0006886
GO:0000166
catabolictranscript_biotype:processed_transcript// intracellular
GO:0005623
process
nucleotide////GO:0006888
GO:0003924////transport//cellbinding
GO:0005737○// cytoplasm//////GO:0006897//GO:0005515
intracellular
GTPase// GO:0005768// endosome
activity
protein////GO:0006914
GO:0005525// transport
protein//// early
GO:0005bindinendo//////GEGENSMUST00000101477
Peli1
pellino 1
ENSMUST00000101477
ENSEMBL havana:known FALSE
chromosome:GRCm38:11:21135469:21150323:1
67245 Mm.28957 //Q8C669
Mm.403029chr11//gene:ENSMUSG00000020134
Mm.408019
GO:0000209// Mm.408628
protein// GO:0001819
polyubiquitination
gene_biotype:protein_coding
GO:0005634// GO:0008063
nucleus// positive// regulation
GO:0030890
GO:0004842
transcript_biotype:protein_codingof cytokine
ubiquitin-protein////GO:0031398
GO:0005515
production○ transferase////GO:0032088//GO:0008766
Toll signaling
activity////GO:0032496
pathway
GO:0016874// protein//binding
positiv////GG
NM_001290676
Cpeb4
cytoplasmic polyadenylation
NM_001290676
RefSeqelement binding
Mus musculus
protein FALSE
4cytoplasmic polyadenylation
67579 Mm.339792
element
Q7TN98binding protein
chr114 (Cpeb4),
GO:0002931
transcriptresponse
variant// GO:0035235
2,tomRNA.
ischemia
GO:0005634// GO:0036294// ionotropic
nucleus// GO:0005634//glutamate
nucleus
GO:0042149
GO:0000166// GO:0005737//
receptorcytoplasm
nucleotide////GO:0043524
GO:0003676
signaling////cytoplasm
binding
GO:0005737○
pathway////GO:0071230//GO:0003723
nucleic////endoplasmic
cellular// GO:0005783
acidresponse//binding//GO:0071230
GO:0044822
reticulum//to//GO:0014
RNA
decrease// //posbin//GG
NM_177364 Sh3pxd2b SH3 and PXNM_177364
domains 2BRefSeq
Mus musculus FALSE
SH3 and PX domains
268396 2B
Mm.227616(Sh3pxd2b),
A2AAY5
mRNA. chr11
GO:0001501skeletal// GO:0001501
system
GO:0002102
development// GO:0001654
podosome// GO:0005737// skeletal// GO:0001654//GO:0010314
cytoplasm
system// GO:0030054
development
phosphatidylinositol-5-phosphate//////cell
GO:0006801
GO:0032266
junction// GO:0042995//○eye// //cell
development//GO:0007507
GO:0035091
projection// GO:0002102////
bindingeyepodosome//GO:0007507
GO:0042169
development// phosphat
GO:0005// cytop////G//G
NM_145962 Pank3
pantothenateNM_145962
kinase 3 RefSeq
Mus musculus FALSE
pantothenate 211347
kinase 3 Mm.255044(Pank3), mRNA.
Q8R2W9 chr11
GO:0015937coenzyme// GO:0016310
A GO:0005737
biosynthetic// GO:0015937
cytoplasm
process// GO:0005737//// GO:0016310//
phosphorylation
GO:0000166
cytoplasm nucleotide// //GO:0004594
coenzyme
binding○ A //biosynthetic//GO:0005524
pantothenate
process//kinase
GO:0016301// activity
phosphoryl//// AG
NM_001024205
Nufip2
nuclear fragile
NM_001024205
X mental retardation
RefSeq protein
Mus musculusinteractingFALSE
nuclearproteinfragile
2
X
68564
mentalMm.428996
retardation Q5F2E7protein interacting
chr11 protein---2 (Nufip2), --mRNA.
GO:0005634nucleus// GO:0005737// cytoplasm
GO:0003723// GO:0042788// polysomal
RNA// GO:0044822
binding//ribosome
GO:0005634○// poly(A)// GO:0003723// nucleus
RNA// GO:0005634
binding// nucleus// GO:0003723// RNA////GO:0005
cytoplasbinding
NM_016686 Vezf1
vascular endothelial
NM_016686
zinc finger
RefSeq1
Mus musculus FALSE
vascular endothelial
22344zinc
Mm.46628
finger 1 (Vezf1),
Q5SXC3mRNA.
chr11
GO:0001525angiogenesis// GO:0001885
GO:0005634// endothelial
nucleus//cell
GO:0005634
development// nucleus
GO:0003676nucleic// GO:0046872
acid ○
binding // metal ion binding
NM_201609 Zfp652
zinc finger protein
NM_201609
652 RefSeq
Mus musculus FALSE
zinc finger protein
268469652 Mm.389038(Zfp652), mRNA.
Q5DU09// Mm.418731
chr11
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_001081434
Osbpl7
oxysterol binding
NM_001081434
protein-like
RefSeq7
Mus musculus FALSE
oxysterol binding
71240
protein-like
Mm.190450
7 (Osbpl7),
A2A716
mRNA.chr11
GO:0006810transport// GO:0006869// lipid
GO:0005776
transport// GO:0071397
autophagic// GO:0005829
cellular// GO:1901800
vacuoleresponse
GO:0015485// GO:0005886//tocytosol
cholesterol
cholesterol////GO:0071397
GO:0015485// plasma// //GO:0097038
binding○
positivemembrane// GO:1901800//regulation
cholesterol// GO:0005776// perinuclearof binding
proteasomal
endoplasmic// GO:0005
protein
NM_138657 Socs7
suppressor ofNM_138657
cytokine signaling
RefSeq7
Mus musculus FALSE
suppressor of 192157
cytokine Mm.34339
signaling 7 (Socs7),
Q8VHQ2mRNA.
chr11
GO:0008286insulin// GO:0009968
receptor
GO:0005634
signaling// GO:0016567
nucleuspathway// GO:0005730////nucleolus
GO:0035556
negative--- // GO:0005737
regulation// cytoplasm--// GO:0040008
of signal////GO:0005886
plasma○ transduction// GO:0045444
membrane// GO:0016020// protein////membrane
GO:0016567
ubiquitination// GO:0043// intrac/
NM_139311 Mllt6
myeloid/lymphoid
NM_139311
or mixed-lineage
RefSeq leukemia
Mus musculus(trithorax
FALSE
myeloid/lymphoidhomolog, Drosophila);
246198or mixed-lineage
Mm.23685
translocatedB1AR09
leukemia
to, 6(trithorax
chr11 homolog,
GO:0008150
Drosophila);
biological_processtranslocated
GO:0005575
to, 6 (Mllt6),
cellular_component
mRNA. GO:0046872metal// GO:0003674
ion binding○ //// GO:0008270
molecular_function // zinc ion bin
NM_001110778
Adam11a disintegrin NM_001110778
and metallopeptidase
RefSeq domain
Mus musculus
11
FALSE
a disintegrin and
11488
metallopeptidase
Mm.89854 domain
Q9R1V411 (Adam11),
chr11
transcript
GO:0006508
variantproteolysis//
1, GO:0007229
mRNA. //GO:0016020
integrin-mediatedmembrane// GO:0016021
signaling//GO:0004222
integralpathway
component
metalloendopeptidase// GO:0005515
of membrane○ // GO:0008237
activity // protein// GO:0008270
binding // me
NM_016780 Itgb3
integrin beta NM_016780
3
RefSeq
Mus musculus FALSE
integrin beta 3 16416(Itgb3), Mm.87150
mRNA.
O54890
chr11
GO:0001938positive// GO:0002687
regulation
GO:0005634//ofGO:0006457
endothelial
nucleus// GO:0005886
cell// plasma
GO:0006874
proliferation
GO:0003756//membrane
GO:0005925//protein//positive//GO:0007044
GO:0004872// disulfide
focal//
regulation
GO:0008305○
adhesion
isomerase////GO:0007155
of
GO:0005178
leukocyte// integrin// activity
GO:0009897
migration//complex//GO:0007160//GO:0005515
receptor//////GO:0009
proteinexternal
activity////GfoG
NM_015732 Axin2
axin2
NM_015732 RefSeq
Mus musculus FALSE
axin2 (Axin2), mRNA.
12006 Mm.71710 O88566
chr11
GO:0001756somitogenesis// GO:0001934
GO:0005622// positive// GO:0001957
intracellular
regulation// GO:0005634// of
GO:0003139
GO:0004871//protein
nucleus// GO:0005634
phosphorylation//signal//nucleus//GO:0003413
GO:0005096
transducer//// GO:0005737
cytoplasm○// intramembranous//activity//GO:0006355
GO:0005515// centrosome//// GO:0005813
GTPaseossification////GO:0007275
GO:0008013
activator// centrosome// GO:0005//activity
secon////GG
NM_198022 Tnrc6c
trinucleotide NM_198022
repeat containing
RefSeq
6C
Mus musculus FALSE
trinucleotide repeat
217351
containing
Mm.40272
6C (Tnrc6c),
Q3UHC0mRNA.
chr11
GO:0001706endoderm// GO:0006417
formation
GO:0005575// GO:0007492// regulation
cellular_componentof// translation
GO:0031047
GO:0000166// endoderm
nucleotide////GO:0035162
GO:0003676
development
binding○ ////GO:0048568//GO:0003723
nucleic// geneacid
silencing//binding//GO:0060213
GO:0003674
by// RNA
RNA//bin//Ge
NM_146016 Eml6
echinoderm microtubule
NM_146016associated
RefSeqproteinMus musculus
like 6
FALSE
echinoderm microtubule
237711 Mm.445271
associatedQ5SQM0
protein like 6
chr11(Eml6), mRNA.
GO:0008150biological_process
GO:0005737cytoplasm// GO:0005856//GO:0003674
cytoskeleton// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_010250 Gabra1
gamma-aminobutyric
NM_010250
acidRefSeq(GABA) A receptor,
Mus musculus
subunit
FALSE
gamma-aminobutyricalpha 1
14394 acid
Mm.439668(GABA) P62812
A receptor, subunit
chr11 alphaGO:0006810
1 (Gabra1), transportmRNA.
// GO:0006811// ion
GO:0005886
transport// GO:0006821
plasma////chloride
GO:0005887
membrane// transport
GO:0007165
GO:0004890// //GO:0016020//integral
signalGABA-A////GO:0007214
GO:0005216
transduction
component//
receptor
GO:0016021
○ of
////
activity//GO:0051932
plasma
GO:0005230
gamma-aminobutyric////membrane
GO:0030054
ion channel////GO:0034220
GO:0005254// activity
membrane//acid
GO:0034
signali//////ext
GG
NM_172524 Nipal4
NIPA-like domain
NM_172524
containing
RefSeq4
Mus musculus FALSE
NIPA-like domain
214112
containing
Mm.225253
4 (Nipal4),
Q8BZF2
mRNA.chr11
GO:0006810transport// GO:0006811// ion
GO:0016020
transport// GO:0015693
membrane////magnesium
GO:0016021// GO:0015693//GO:0015095
integralion//transport
GO:0005575
component
magnesium// GO:0003674// magnesiumof membraneion○ transmembrane
ion transport// cellular_component
transporter activity //NM_001029988
Fat2
FAT tumor suppressor
NM_001029988
homolog
RefSeq2 (Drosophila)
Mus musculus FALSE
FAT tumor suppressor
245827 Mm.339363
homolog 2 (Drosophila)
Q5F226(Fat2),
chr11 mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005634// homophilic// GO:0010631
nucleus//cell
GO:0005886
adhesion// plasma
GO:0007156
GO:0005509////membrane
epithelial
GO:0005913
calcium// GO:0007156
cell// migration
cell-cellion// GO:0016020
binding○ adherens////GO:0010631
homophilic//junction
GO:0016021
cell
// //
GO:0010631
adhesionmembrane// GO:0030// homo// in
NM_144825 Taok1
TAO kinase 1NM_144825 RefSeq
Mus musculus FALSETAO kinase 1216965(Taok1),Mm.340436
mRNA.
Q5F2E8chr11
GO:0000165MAPK// GO:0000186
cascadeGO:0005737////activation
GO:0006281
cytoplasm// of
GO:0070062
MAPKK// GO:0006468//GO:0000166
extracellular
activity// GO:0005737// nucleotide
DNA//vesicular//GO:0006915
GO:0004672
repair//exosomebinding
GO:0005737○// protein////GO:0006950//GO:0004674//protein
phosphorylation
cytoplasm
kinase//////GO:0006974
activitycytoplasm
GO:0004709// apoptotic// protein
//pro
//GG
NM_008702 Nlk
nemo like kinase
NM_008702 RefSeq
Mus musculus FALSE
nemo like kinase
18099(Nlk),Mm.9001
mRNA.
O54949chr11
GO:0000165MAPK// GO:0006351
cascadeGO:0005634////transcription,
GO:0006355
nucleus// GO:0005737
DNA-templated// cytoplasm
GO:0006468
GO:0000166// GO:0005634// //nucleus
nucleotide//regulation//GO:0007179
GO:0000287
bindingof○transcription,////GO:0016055//GO:0004672
magnesium
DNA-templated//ion//GO:0016310
GO:0004674
binding// protein// prote////GG
NM_013571 Ksr1
kinase suppressor
NM_013571
of ras 1RefSeq
Mus musculus FALSE
kinase suppressor
16706
of rasMm.4745
1 (Ksr1), mRNA.
Q61097chr11
GO:0006468protein// GO:0016310
phosphorylation
GO:0005737// GO:0035556//cytoplasm
phosphorylation// GO:0005783// GO:0043410//GO:0004672
endoplasmic//// GO:0016020
intracellular
protein
reticulum// GO:0004674
signalkinase// GO:0005789//○transduction
membrane
activity// GO:0005078// protein////endoplasmic
positiveserine/threonine// GO:0005515
regulation
reticulum
ofkinasMA//mG
NM_019505 Dgke
diacylglycerolNM_019505
kinase, epsilon
RefSeq
Mus musculus FALSE
diacylglycerol kinase,56077 epsilon
Mm.153695(Dgke),
Q9R1C6
mRNA. chr11
GO:0007205protein// GO:0008152
kinase
GO:0005737
C-activating// GO:0016310
cytoplasm//
G-protein
GO:0016020// GO:0035556//coupled
GO:0000166
membrane// GO:0016021
receptor
nucleotide////integral
GO:0003951
signaling//component
binding
GO:0005737○
pathway// //GO:0004143
NAD+of// membrane
metabolic// GO:0016020
kinase//activity
process
GO:0005524// cytoplasm////diacylgl
phosph//// mG
NM_001081045
Kansl1
KAT8 regulatory
NM_001081045
NSL complex
RefSeqsubunitMus
1 musculus FALSE
KAT8 regulatory
76719
NSL complex
Mm.136418
subunit
Q80TG11 (Kansl1),
chr11
mRNA. GO:0016568chromatin// GO:0043981
modification
GO:0000123// GO:0043982//histone
histone// GO:0005634
acetyltransferase
H4-K5// GO:0043984
GO:0043995
acetylation// GO:0071339
histonecomplex////GO:0043981//GO:0043996
histoneacetyltransferase//// GO:0000123
nucleusH4-K8○ ////GO:0043981
acetylation
GO:0046972// MLL1
activity// GO:0000123
complex//(H4-K5//histone//GO:0043982
GO:0043995// specific)
histoneH4-K16// GO:0005
acety
//ace
////GhG
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus FALSE
H3 histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244
chr11
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_011358 Srsf2
serine/arginine-rich
NM_011358
splicing
RefSeqfactor 2 Mus musculus FALSE
serine/arginine-rich
20382
splicing
Mm.21841
factor 2//Q62093(Srsf2),
Mm.469331
mRNA.
chr11
GO:0006397mRNA// GO:0008380
processing
GO:0005634// RNA
nucleus//splicing
GO:0005634// nucleus
GO:0000166// GO:0005681// spliceosomal
nucleotide// GO:0003676//complex
binding
GO:0016607○ // //GO:0003723//nucleic
nuclear// GO:0016607
acid
speck
binding// GO:0005515// nuclear////GO:0005
RNA
speck
bin
// G
NM_001099628
Atad2bATPase family,
NM_001099628
AAA domain
RefSeqcontainingMus
2Bmusculus FALSE
ATPase family,
320817AAA domain
Mm.210966
containing
E9Q1662B (Atad2b),
chr12 mRNA.GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleusprocess
GO:0000166nucleotide// GO:0005524
binding○ // //GO:0070577
ATP binding ////GO:0017111
lysine-acetylated// G
XM_006516065
Rgs6
regulator of G-protein
XM_006516065
signaling
RefSeq6
PREDICTED: Mus
FALSE
musculus regulator
50779 Mm.153013
of G-proteinQ9Z2H2
signaling 6 chr12(Rgs6), transcript
GO:0007165
variant signal
X2,// GO:0007186
mRNA.
transduction
GO:0005737// //GO:0009968
G-proteincytoplasm// GO:0005794
coupled// GO:0035556//GO:0004871
Golgi
receptor//apparatus
GO:0005834
signaling
signal////GO:0038032
GO:0005096//transducer
heterotrimericpathway// GO:0005886○ //activity//GO:0043547
GO:0005096
negative
G-protein//// GO:0016020
GTPaseregulation
complex////GO:0045666
GO:0005515
activator
of////signal
plasma
GO:0043
activity
trans
////m
GG
NM_028821 Dnal1
dynein, axonemal,
NM_028821
light chain
RefSeq1
Mus musculus FALSE
dynein, axonemal,
105000lightMm.101525
chain 1 (Dnal1),
Q05A62
mRNA.chr12
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
ENSMUST00000134311
Fos
FBJ osteosarcoma
ENSMUST00000134311
oncogene
ENSEMBL havana:putativeFALSE
chromosome:GRCm38:12:85474911:85476063:1
14281 Mm.246513 P01101// Mm.472279
chr12
gene:ENSMUSG00000021250
GO:0006355regulation// GO:0006355
gene_biotype:protein_codingof GO:0005634
transcription,// GO:0006366
nucleus
DNA-templated// GO:0005634// nucleus
GO:0007179
GO:0000979
transcript_biotype:processed_transcript// regulation
GO:0005634// nucleus
RNA////GO:0007399
GO:0003677
ofpolymerase// transcription,transcription// GO:0005667○ //II//GO:0031668
core
GO:0003677
factorDNA-templated
promoter// complex
GO:0005737//sequence-specific//GO:0034614
GO:0003690////cytoplasm
transcription// GO:0005//////GeDG
NM_177354 Vash1
vasohibin 1 NM_177354 RefSeq
Mus musculus FALSE
vasohibin 1 (Vash1),
238328mRNA.
Mm.216101 Q8C1W1 chr12
GO:0001525angiogenesis// GO:0001937
GO:0005576// negative// GO:0007049
extracellular
regulation// GO:0005615//of
GO:0007050
GO:0003674
regionendothelial// //GO:0005737
extracellularcellmolecular_function// GO:0009611
proliferation//
space
GO:0005783○ //// cell
cytoplasm
GO:0010596
cycle// GO:0045177// //cell
endoplasmic// cycle
GO:0010628
arrest// GO:0005
reticulum
// //
resp
G
NM_001025358
Klc1
kinesin light chain
NM_001025358
1
RefSeq
Mus musculus FALSE
kinesin light chain
16593
1 (Klc1),
Mm.278357
transcript
O88447variant b, chr12mRNA.
GO:0006886intracellular// GO:0007018
proteinGO:0005622// transport
GO:0008088
intracellular// GO:0005623// microtubule-based// GO:0035418
GO:0003777// cell// //GO:0005737
cytoplasm
microtubule//
movement//GO:0035617
GO:0005515// //cytosol
GO:0005829
motor○// axon////GO:0008152
activitycargo
GO:0015631
cytoskeleton//transport//GO:0005856
protein//////GO:0006886
kinesin//GO:0015631
binding
protein// complex
GO:0005//localizat
tubulin// G
NM_021361 Nova1
neuro-oncological
NM_021361
ventral RefSeq
antigen 1 Mus musculus FALSE
neuro-oncological
664883ventralMm.247195
antigen 1 Q9JKN6(Nova1), mRNA.
chr12
GO:0000398mRNA// GO:0000398
splicing,
GO:0005634
via// spliceosome
GO:0007399
nucleus// GO:0005634//// mRNA
nucleus
GO:0051252
GO:0003723
splicing,// GO:0005730// nucleolus
RNA
via// GO:0003729
spliceosome
binding// //intracellular
GO:0043231○// mRNA////GO:0005515
nervousmembrane-boundedbinding// GO:0005634
system// protein// GO:0044822
development
binding
organelle////pNM_001003719
Ralgapa1 Ral GTPase NM_001003719
activating protein,
RefSeqalpha subunit
Mus musculus
1
FALSE
Ral GTPase activating
56784 Mm.292180
protein, alphaQ6GYP7subunit 1 (Ralgapa1),
chr12transcript
GO:0006355
variant
regulation// GO:0032853
3, mRNA.
of GO:0005634
transcription,// GO:0032859
nucleus
DNA-templated// GO:0005737// cytoplasm
GO:0051056
GO:0005096// positive
GO:0005634// nucleus
GTPase////GO:0032859
regulation
GO:0005098//activator//cytoplasm
GO:0005737○
of Ran//activity//GO:0032859
GO:0005515
GTPase// mitochondrion//// GO:0005739
Ran
activity
GTPase// GO:0017123// activation
activatorof//acR
G
NM_177290 Itgb8
integrin beta NM_177290
8
RefSeq
Mus musculus FALSE
integrin beta 8320910(Itgb8), Mm.217000
mRNA.
Q0VBD0chr12
GO:0001573ganglioside// GO:0007155
metabolic
GO:0016020// GO:0007229
process
membrane// GO:0016021// cell// GO:0007160//
adhesion
GO:0005102
integral// GO:0070062
component// integrin-mediatedreceptor////GO:0007275
GO:0004872
ofbinding// membrane
GO:0008305○ signaling////receptor
GO:0005102// extracellularpathway
activity // vesicular
receptorcell-matrix
bindinexosomadh
NM_001039188
Rreb1
ras responsive
NM_001039188
element binding
RefSeqproteinMus
1 musculus FALSE
ras responsive 68750
elementMm.491109
binding protein
Q3UH061 (Rreb1),
chr13
transcript variant
GO:0006351
2, mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// GO:0005737// regulation// cytoplasm
GO:0003676
of// GO:0070062
transcription,// extracellular
nucleic// GO:0003677
acid
DNA-templated// GO:0005634
vesicular○binding// GO:0003700//exosomeDNA//// negative
GO:0016607
binding// nucleus// regulation
GO:0046872// sequence-spe// nuclearof trans
NM_153789 Mylip
myosin regulatory
NM_153789
light chain
RefSeqinteractingMus
proteinmusculus FALSE
myosin regulatory
218203lightMm.212855
chain interacting
Q8BM54protein chr13(Mylip), mRNA.
GO:0006928cellular// GO:0007399
component
GO:0005622// movement
GO:0010989
intracellular// GO:0005737// nervous// GO:0016567
GO:0004842// cytoplasm
system// GO:0005856
development
ubiquitin-protein//////GO:0016567
cytoskeleton
GO:0004842// GO:0005886○// negativetransferase////GO:0031648
plasma
GO:0008092
regulation//membrane
GO:0016020
activity////of
GO:0032803
GO:0008270//low-density
ubiquitin-protei// membrane// GO:0019
lipop////GG/
NM_001081425
Rbm24
RNA bindingNM_001081425
motif proteinRefSeq
24
Mus musculus FALSE
RNA binding motif
666794proteinMm.38269
24 (Rbm24),
D3Z4I3
mRNA. chr13
GO:0010830regulation// GO:0030154
of GO:0005634
myotube// GO:0043488
differentiation
nucleus// GO:0005737// cytoplasm//GO:0000166
cell differentiation// GO:0005575// cellular_component
nucleotide// GO:0003676// regulation
binding○ // //
of
GO:0003723
nucleic
mRNA acidstability
binding// GO:0003730// RNA bin
AK029314 Tes3-ps
testis derivedAK029314
transcript 3,GenBank
pseudogene
HTC
Mus musculus FALSE
0 day neonate head
54339cDNA,
Mm.441473
RIKEN Q9QZ73
full-length enriched
chr13 library,---clone:4832420G24--product:testis
GO:0000151
derivedubiquitintranscript
ligase--- complex
3, pseudogene,--full insert○ sequence.
NM_172589 Lhfpl2
lipoma HMGIC
NM_172589
fusion partner-like
RefSeq 2 Mus musculus FALSE
lipoma HMGIC
218454
fusion partner-like
Mm.3165532Q8BGA2(Lhfpl2), mRNA.
chr13
GO:0008150biological_process
GO:0016020membrane// GO:0016021//GO:0003674
integral// GO:0005575
componentmoof membrane○// cellular_component
M
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17352884
17353581
17353781
17354906
17355512
1735811917358363
17358905
17360501
17360845
17360873
17363704
17366670
17370043
17370799
17372140
17372161
17372294
17373696
17375961
17376822
17380268
17381357
17384234
17384587
17384813
17384951
17385281
17385508
17386591
17388854
17388931
17389724
17392279
17396492
17396593
17397377
17397827
17398082
17398769
17398863
17399086
17400139
17400339
17401023
17401749
17402698
17405985
17406066
17407764
17408662
17409217
17409839
17412552
17412627
17414045
17414228
17414651
17415231
17417269
17418043
17418857
17419524
17419773
17420024
17421394
17421735
17423107
17423146
17424203
17424215
17425708
17425836
17426497
17430319
17430835
17431075
17431272
17433359
17433528
17435008
17435584
17437674
17438134
17438272
17438602

66.78529
43.51481
41.5438
49.41687
59.4944689.5349
29.54216
23.67311
197.3784
19.77781
58.23682
79.5396
1983.607
100.0365
51.21816
320.7285
156.7047
183.1749
27.9551243.94606
37.77847
219.3302
55.05624
67.65528
385.8456
491.8637
267.1468
20.33561
233.2379
280.0553
200.4437
1358.403
41.66304
118.8745
78.57981
438.0964
25.95703
139.4749
243.0674
342.2083
213.113836.15137
119.3036
1010.162
63.53728
51.81715
50.57511
76.0041112.4812
224.2357
649.6923
449.3233
190.3191
471.9587
41.90462
48.20338
64.56586
35.40636
20.57583
340.1795
38.61799
132.3279
270.071
63.50325
33.76814
66.82102
83.56946
65.06281
587.9049
252.9208
19.6798
467.0081
987.1689
204.9935
126.9374
170.4025
365.8918
102.9478
41.34389
18.30831
32.58324
453.0652
375.5458
130.7116124.9488
581.1381

82.01708
46.36912
43.39374
51.26931
49.08393
777.6544
23.29894
26.00847
166.2378
20.23818
52.97997
75.98012
1682.121
123.48548.73185
368.3455
184.4413
183.8365
26.76316
65.08957
34.65174
207.2804
54.75213
67.00788
477.9493
572.0389
286.1652
20.44731
281.8056
342.1402
243.8269
1523.968
33.86496
126.0638
77.80823
499.3608
23.07682
108.7202
370.4981
409.6244
233.9048
35.28197
138.1467
1055.518
55.56479
59.7676
32.23404
121.4233
115.5079
153.1577
743.4514
540.6808
229.1427
475.9423
41.90457
47.23845
61.83185
29.78446
18.09009
367.2135
36.41235
146.6255
278.9632
61.47142
37.39769
89.3279
67.434143.26445
619.4202
311.8565
22.25351
477.281038.843
203.5372
145.1154
168.7541
392.0241117.4933
46.18327
19.26513
33.75772
392.2232
461.9244
123.686
92.08356
802.8373

0.8142851
0.9384437
0.9573685
0.9638684
1.2120953
0.8866855
1.2679615
0.9102077
1.1873256
0.9772524
1.0992233
1.0468475
1.1792297
0.8101105
1.0510202
0.8707273
0.8496183
0.9964011
1.0445373
0.6751629
1.090233
1.0581328
1.0055543
1.0096616
0.807294
0.8598431
0.9335405
0.9945372
0.8276553
0.8185396
0.8220738
0.8913593
1.2302699
0.9429709
1.0099164
0.8773144
1.1248097
1.2828794
0.6560557
0.8354197
0.9111134
1.0246415
0.8636008
0.9570296
1.143481
0.8669773
1.5689969
0.6259433
0.9737966
1.4640838
0.8738867
0.8310325
0.8305702
0.9916301
1.0000012
1.0204268
1.0442169
1.1887528
1.1374089
0.9263807
1.060574
0.902489
0.9681241
1.0330532
0.9029472
0.748042
1.239276
1.50384
0.9491213
0.8110166
0.8843459
0.9784783
0.950258
1.007155
0.8747342
1.0097681
0.9333401
0.8762015
0.8952136
0.9503341
0.9652086
1.1551209
0.8130027
1.0568019
1.3569067
0.7238554-0.296394-0.091658-0.062854-0.053092
0.2775031-0.173506
0.342511-0.135732
0.2477157-0.033197
0.1364846
0.0660513
0.2378447-0.303809
0.0717904-0.199707-0.235113-0.005201
0.0628641-0.566693
0.1246365
0.0815208
0.007991
0.0138718-0.308834-0.217855-0.099216-0.007903-0.272898-0.288876-0.28266-0.165921
0.2989748-0.084715
0.0142359-0.188834
0.1696809
0.3593855-0.60811-0.259427-0.134297
0.0351192-0.211564-0.063365
0.1934324-0.205934
0.6498425-0.675896-0.038308
0.5499981-0.194482-0.267023-0.267826-0.012126
1.721E-06
0.0291727
0.0624214
0.2494487
0.185751-0.110323
0.0848452-0.148019-0.046736
0.0469146-0.147286-0.418809
0.3094975
0.5886511-0.075336-0.302197-0.177317-0.031388-0.073609
0.0102857-0.193083
0.0140239-0.099525-0.190665-0.159696-0.073493-0.051087
0.2080438-0.298668
0.079705
0.4403215-0.466227

0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main
m
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m
m

NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr18
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_178005 Lrrtm2
leucine rich repeat
NM_178005
transmembrane
RefSeq neuronal
Mus musculus
2
leucine
TRUE rich repeat
107065transmembrane
Mm.39900 Q8BGA3
neuronal 2 (Lrrtm2),
chr18 mRNA.
GO:0002091negative// GO:0050808
regulation
GO:0005886//of
GO:0050808
receptor
plasma// GO:0016020
internalization
membrane// GO:0060291
GO:0042043// //GO:0016021// membrane
synapseneurexin////GO:0050808
GO:0042043
organization//
family// integral
GO:0030054○ proteincomponent// synapse
binding// GO:0045202
organization
of// membrane
neurexin//family
GO:0045// //long-ter
cell
prot
ju
ENSMUST00000097612
Gm10545 predicted gene
ENSMUST00000097612
10545 ENSEMBL ensembl:knownTRUE
chromosome:GRCm38:18:37008869:37020679:-1--Mm.474985 Q3UTM7 chr18gene:ENSMUSG00000073594
GO:0008150biological_process
gene_biotype:protein_coding
GO:0005575cellular_component
GO:0003674
transcript_biotype:protein_coding
molecular_function○
NM_001039485
Piezo2
piezo-type mechanosensitive
NM_001039485
RefSeqion channel
Muscomponent
musculus piezo-typeTRUE
2mechanosensitive
667742 Mm.158720
ion channel
Q8CD54component
chr18 2 (Piezo2),
GO:0006810
mRNA. transport// GO:0006811// ion
GO:0005886
transport// GO:0006812
plasma////cation
GO:0016020
membrane//transport
GO:0006812
GO:0005261// ////
GO:0016021
cationmembranecation////GO:0034220
transport
GO:0008381
channel// integral○// ionactivity////transmembrane
GO:0042391
component
GO:0008381// mechanically-gatedof //membranetransport
GO:0009612//
ionregulachan// G
NM_001164504
Rnf165ring finger protein
NM_001164504
165 RefSeq
Mus musculus ring
TRUE
finger protein
225743165 Mm.23293(Rnf165), mRNA.
E9QAU8chr18
GO:0000209protein// GO:0007409
polyubiquitination
GO:0005634// GO:0008045
nucleus////axonogenesis
GO:0043234// protein
GO:0010259
GO:0004842//complex
motorubiquitin-protein//neuron//GO:0030163
GO:0005515
axon○guidance
transferase////GO:0030513
GO:0008270// multicellular
activity////GO:0035136
GO:0046872// proteinorganismal
binding//ag
G
NM_009551 Zfand5
zinc finger, AN1-type
NM_009551
domainRefSeq5
Mus musculus zinc
TRUE
finger, AN1-type
22682 domain
Mm.292405
5 (Zfand5),
O88878mRNA.
chr19
GO:0001701in//utero
GO:0001944
embryonic
GO:0005737//development
GO:0003016
cytoplasm////vasculature
GO:0010761
GO:0003677
development
DNA////GO:0048008
GO:0008270
binding//○
respiratory// zinc////GO:0048705
GO:0046872
ion systembinding process// metal
GO:0048745//
ionfibroblastbinding// Gm
NM_177360 Dmrt3
doublesex and
NM_177360
mab-3 related
RefSeqtranscription
Mus factor
musculus
3 doublesex
TRUE
and240590
mab-3 related
Mm.62785transcription
Q80WT2
factorchr19
3 (Dmrt3), mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005634// regulation// nucleus
GO:0007548
GO:0003677
of transcription,
DNA////GO:0007628
GO:0003700
binding
DNA-templated○// sequence-specific////GO:0019226
GO:0043565// multicellular////DNA
GO:0021521
GO:0046872
organismal
binding trans
////G
de
G
NM_001163471
Hectd2
HECT domain
NM_001163471
containingRefSeq
2
Mus musculus HECTTRUE domain226098
containing
Mm.61107
2 (Hectd2),
Q8CDU6transcript chr19
variant 1, mRNA.
GO:0042787protein// GO:0016567
ubiquitination
GO:0005634// GO:0042787
involved
nucleus// GO:0005737
in ubiquitin-dependent// cytoplasm
GO:0004842// GO:0005634// nucleus
ubiquitin-protein//protein
GO:0008766////catabolic
cytoplasm
GO:0005737○ transferase// process
GO:0016874
activity// protein// GO:0018169// ubiquitination
UDP-N-acetylm// G/
NM_001142918
Tcf7l2transcription NM_001142918
factor 7 like 2,
RefSeqT cell specific,
Mus musculus
HMG box transcription
TRUE
factor21416
7 likeMm.139815
2, T cell specific,
Q924A0HMGchr19
box (Tcf7l2),GO:0000122
transcript variant
negative// GO:0000122
1, mRNA.
regulation
GO:0000790//ofGO:0001568
transcription
nuclear// GO:0005634
chromatin//from
GO:0005977
GO:0000978
RNA////GO:0005634
polymerase
nucleusRNA////GO:0006006
GO:0000978//polymerase
nucleusII //promoter
GO:0005654○ ////II//nucleoplasm
GO:0006351//
core
GO:0001103
negative
promoter// GO:0005667
regulation////proximaltranscription//GO:0006355
GO:0003677
of//regiontranscripti
GO:0005
factor//seq//GG
NM_010132 Emx2
empty spiracles
NM_010132
homeobox
RefSeq2
Mus musculus empty
TRUE spiracles13797
homeobox
Mm.245394
2 (Emx2),
Q04744
mRNA. chr19
GO:0006355regulation// GO:0007275
of GO:0005634
transcription,// GO:0007420
nucleus
DNA-templated// GO:0009952
GO:0000976// multicellulartranscription////GO:0009952
GO:0003677
organismal○
regulatory////GO:0010468
development
GO:0003700
region sequence-specific////GO:0021542
brain
GO:0043565
developmen
DNA// G
NM_178421 Nanos1
nanos homolog
NM_178421
1 (Drosophila)
RefSeq
Mus musculus nanos
TRUE homolog
332397
1 (Drosophila)
Mm.186390(Nanos1),
Q80WY3
mRNA.chr19
GO:0006417regulation// GO:0010631
of GO:0005737
translation// GO:0016477//cytoplasm
epithelial// GO:0048471// cell
GO:0010631//GO:0003723
perinuclear
migration// GO:0005737
RNA
region// //cell
GO:0010631
GO:0008270
binding
migrationof //cytoplasm
GO:0005737○// zinc////GO:0016477
epithelial
GO:0046872
ion// cytoplasm
binding// GO:0048471
cell migration////metal
GO:0016477
cytoplasm
GO:0003674
ion////GO:0048
bindingepithelia// //per//GG
NM_001166414
Rfx3
regulatory factor
NM_001166414
X, 3 (influences
RefSeq HLA Mus
classmusculus
II expression)
regulatory
TRUE
factor19726
X, 3 (influences
Mm.313321
HLA
P48381class II expression)
chr19(Rfx3),
GO:0006351
transcripttranscription,//variant
GO:0006355
2, mRNA.
GO:0000790
DNA-templated// GO:0007275
nuclear// GO:0000790// regulation
chromatin// GO:0007368
GO:0003677
of////GO:0005634
transcription,
nuclearDNA////GO:0030154
GO:0003700
chromatin
binding
DNA-templated// GO:0005667○////sequence-specific//nucleus//GO:0031018
GO:0005515//////multicellular
GO:0000790
transcription////DNA
GO:0042384
GO:0044212
organismal
bindingfactor comp
trans
////G
de
G
NM_172471 Itih5inter-alpha (globulin)
NM_172471
inhibitor
RefSeqH5
Mus musculus inter-alphaTRUE(globulin)
209378inhibitor
Mm.313876
H5 (Itih5),
Q8BJD1
mRNA.chr2
GO:0010466negative// GO:0030212
regulation
GO:0005576//of
GO:0008150
peptidase
extracellular// GO:0005575
activity// GO:0010951
GO:0004867
region// hyaluronan// cellular_component
serine-type// GO:0030414
metabolicendopeptidase○process// GO:0003674// biological_process
inhibitor activity ////peptidas
negativ
NM_011923 Angptl2
angiopoietin-like
NM_011923
2
RefSeq
Mus musculus angiopoietin-like
TRUE
26360
2 (Angptl2),
Mm.208919
mRNA.
Q9R045chr2----GO:0005576extracellular// GO:0070062--region // extracellular--vesicular○exosomeENSMUST00000124210
A430018G15Rik
RIKEN cDNAENSMUST00000124210
A430018G15ENSEMBLgene
havana:known chromosome:GRCm38:2:52425012:52431893:1
TRUE----Q8R0S4
chr2
gene:ENSMUSG00000085315----gene_biotype:processed_transcript------- transcript_biotype:processed_transcript--○
NM_053263 Hnrnpa3
heterogeneous
NM_053263
nuclear ribonucleoprotein
RefSeqMusA3
musculus heterogeneous
TRUE
229279nuclearMm.316306
ribonucleoprotein
Q8BG05// Mm.331491
A3 (Hnrnpa3),
chr2// Mm.379375
transcript
GO:0006397
variant mRNAc,//mRNA.
GO:0008380
processing
GO:0005634// //GO:0051028
RNA
nucleus//splicing
GO:0005681// //spliceosomal
GO:0055085
GO:0000166
mRNA// GO:0005737
transport
complex
nucleotide// GO:0003676// transmembrane// binding
cytoplasm
GO:0019012○ // //GO:0003723
nucleic//transportvirion// GO:0019013
acid// viralbinding// GO:0003729
nucleocapsid////GO:0030
RNA bin// /G
NM_172666 Agps
alkylglycerone
NM_172666
phosphateRefSeq
synthase Mus musculus alkylglycerone
TRUE
228061
phosphate
Mm.31227
synthase Q8C0I1(Agps), mRNA.
chr2
GO:0006629lipid// GO:0008610
metabolic
GO:0005730
process// GO:0055114//nucleolus
lipid// GO:0005739
biosynthetic// //GO:0008610
GO:0003824
mitochondrion//processGO:0005739
catalytic//////GO:0008611//GO:0008609
oxidation-reduction
mitochondrion
activity// GO:0005777○ //////GO:0008611
alkylglycerone-phosphate
GO:0008762// peroxisome
process// GO:0005778// //lipid//GO:0016491
peroxisomal
biosynthetic// GO:0043
synthaseme//pG
ENSMUST00000028398
Ube2e3ubiquitin-conjugating
ENSMUST00000028398
enzymeENSEMBLE2E 3 ensembl_havana_transcript:known
TRUE
22193chromosome:GRCm38:2:78869047:78921293:1
Mm.1485 // P52483
Mm.396925 chr2// Mm.426742
GO:0040008
gene:ENSMUSG00000027011
regulation// GO:0070534
of GO:0005634
growth// GO:0070936// protein
nucleus//gene_biotype:protein_coding
GO:0005737
K63-linked// cytoplasm
GO:0070979
GO:0000166
ubiquitination// GO:0005634// nucleus
nucleotide////GO:0070534
GO:0004842//transcript_biotype:protein_coding
proteinbinding○ K48-linked////GO:0070936//GO:0005515
ubiquitin-protein
ubiquitination////GO:0070979
GO:0005524
transferase// protein//acti//K1
GG
NM_011393 Slc1a2
solute carrierNM_011393
family 1 (glial
RefSeqhigh affinityMus
glutamatemusculustransporter),soluteTRUE carrier
memberfamily20511
21 (glial
Mm.267547
high affinity
P43006glutamatechr2
transporter),
GO:0006810
member 2transport(Slc1a2),// GO:0006835//transcript
dicarboxylic
GO:0005886// GO:0007399
variant
acid
plasma//3,GO:0005887
transportmRNA.
membrane// GO:0007632
GO:0005313// nervous// //GO:0016020
integralsystemL-glutamate////GO:0009416
GO:0005313
component
development// GO:0016021○
transmembraneof////GO:0009611
plasma
GO:0005314// visual// membrane
GO:0030424
transporter
behavior////GO:0010259
GO:0015293////activity
membrane
response// GO:0030////L-g//to
GG
NM_009754 Bcl2l11
BCL2-like 11NM_009754(apoptosis facilitator)
RefSeq
Mus musculus BCL2-likeTRUE
11 (apoptosis
12125 Mm.141083
facilitator) (Bcl2l11),
O54918 transcript
chr2 variant
GO:0001701
3, mRNA. in//utero
GO:0001776
embryonic
GO:0005622//development
GO:0001776
intracellular// GO:0005737////leukocyte
GO:0001782
GO:0005515// cytoplasm// GO:0005739
homeostasis
protein//////GO:0001782
mitochondrion
GO:0008017
binding//// leukocyte
GO:0005739○ //////
microtubule//
GO:0001783
GO:0008017
mitochondrion
homeostasis// GO:0005739
binding// //GO:0001822//Bmitochondrioncell// microtubule//homeostas
GO:0005// G
NM_001291056
Snap25synaptosomal-associated
NM_001291056
RefSeqprotein 25 Mus musculus synaptosomal-associatedTRUE
20614 Mm.45953
protein 25P60879(Snap25), transcript
chr2
variant
GO:0007269
2, mRNA.
neurotransmitter// GO:0007616
GO:0005623
secretion// GO:0010975
cell//// GO:0005737
long-term// cytoplasm// GO:0016197
GO:0000149
memory// GO:0005737
cytoplasm//SNARE//regulation//GO:0030431
GO:0000149// binding
endosome// of
GO:0005768○neuron//////GO:0034765
SNARE
GO:0005249//projection
trans-Golgi// GO:0005802
bindingdevelopment//network//GO:0046887
GO:0005515// voltage-gated////GO:0005
cytosol// endos////GpG
NM_019806 Vapb
vesicle-associatedNM_019806
membrane
RefSeqprotein,Mus
associatedmusculus
proteinvesicle-associated
TRUE
B and C 56491
membrane
Mm.260456
protein,
Q9QY76
associatedchr2
protein B and
GO:0006874
C (Vapb),cellularmRNA.
// GO:0006986
calcium
GO:0005783
ion// homeostasis
GO:0006987
endoplasmic// GO:0005789////response
GO:0019048
GO:0005198
reticulum// GO:0005794
to unfolded//structural//endoplasmic//GO:0030968
GO:0019899
protein//molecule
GO:0016020○reticulum// //activation//GO:0045070
activity
GO:0042803
membrane// of
GO:0016021// signaling
enzyme////GO:0006874//GO:0046982
Golgi
binding
protein// GO:0005
apparatus
activity// prote////GG
NM_001290376
Camk1dcalcium/calmodulin-dependent
NM_001290376
RefSeqproteinMus
kinasemusculusID
calcium/calmodulin-dependent
TRUE
227541 Mm.191949
protein
Q8BW96kinase IDchr2(Camk1d), transcript
GO:0006468
variant
protein// GO:0006954
4, mRNA.
phosphorylation
GO:0005634// GO:0007399//nucleus
inflammatory// GO:0005737// cytoplasm
GO:0008152
GO:0000166
response// GO:0005634// nucleus
nucleotide//////nervous
GO:0010976
GO:0003824////nucleus
systembinding
GO:0005634○ ////development
GO:0016310//GO:0004672
catalytic
cytoplasm// GO:0005737
activity//////
metaboliccytoplasm
GO:0032793
GO:0004674// protein// GO:0005
processkinas////GG
NM_001290576
Pbx3
pre B cell leukemia
NM_001290576
homeobox
RefSeq3
Mus musculus pre
TRUE
B cell leukemia
18516
homeobox
Mm.239941
3 (Pbx3),
O35317transcript
chr2
variant b, GO:0002087
mRNA.
regulation// GO:0006351
of GO:0005634
respiratory// GO:0006355
gaseousnucleus// GO:0005667
exchange// transcription
GO:0007585
GO:0003677
by// GO:0005634
neurologicalfactorDNA////GO:0008344
GO:0003700
complexbindingsystem○////sequence-specificprocess
nucleus////GO:0021516
GO:0005515// transcription,////DNA
GO:0048666
GO:0043565
binding
DNA-templa
trans
// G
NM_001100591
Rc3h2
ring finger and
NM_001100591
CCCH-type
RefSeqzinc finger Mus
domains
musculus
2
ring
TRUE
finger and319817
CCCH-type
Mm.288785
zinc finger
P0C090domains 2chr2(Rc3h2), transcript
GO:0000209
variant
protein//1,
GO:0001782
mRNA.
polyubiquitination
GO:0005634// GO:0009791
nucleus////BGO:0005737
cell //homeostasis
cytoplasm
GO:0010468
GO:0003677// GO:0009986//// cell
post-embryonic
DNA////GO:0010608
surface
GO:0003723
binding// GO:0016020//○membrane// development
RNA////GO:0035264
GO:0003729
binding//// GO:0000932
cytoplasmic// regulation
mRNA////GO:0042098
GO:0004842
bindingmRNA//ofGO:0005
gene
proce
////ubiexp//GG
ENSMUST00000028087
Ppp6c
protein phosphatase
ENSMUST00000028087
6, catalytic
ENSEMBL
subunitensembl_havana_transcript:known
TRUE
67857chromosome:GRCm38:2:39194354:39226451:-1
Mm.389242 Q9CQR6// Mm.171389
chr2// Mm.392662
GO:0006470// Mm.398121
gene:ENSMUSG00000026753
protein// GO:0007049
dephosphorylation// Mm.475023
GO:0005737// GO:0006470
cytoplasm// gene_biotype:protein_coding
GO:0005829
cell cycle// GO:0006470//GO:0004721
cytosol// protein// GO:0005829// cytosol
dephosphorylation
phosphoprotein// GO:0004722//transcript_biotype:protein_coding
cytosol// GO:0005829○ phosphatase// GO:0016787
protein dephosphorylation
activity// GO:0046872// protein serine/// G
NM_001289521
Zeb2
zinc finger E-box
NM_001289521
binding RefSeq
homeobox 2 Mus musculus zinc
TRUE
finger E-box
24136
binding
Mm.440702
homeoboxQ9R0G7
2 (Zeb2), transcript
chr2
variant
GO:0001755
3, mRNA.neural// GO:0001756
crest cell
GO:0005634
migration// GO:0001843
nucleus// GO:0005634
somitogenesis// nucleus
GO:0006351
GO:0003676// //GO:0005730//neuralnucleolus
nucleic////GO:0006355
tube
GO:0003677
acid//closure//cytoplasm
GO:0005737○
binding// //transcription,
GO:0007417
GO:0003700// DNA binding
DNA-templated////GO:0021766
GO:0043565// sequence-spe//////reg
GG
NM_001037099
Cacnb4
calcium channel,
NM_001037099
voltage-dependent,
RefSeqbeta
Mus 4musculus
subunit calcium
TRUE channel,
12298
voltage-dependent,
Mm.330223 Q8R0S4
beta 4 subunit
chr2 (Cacnb4),
GO:0006810
transcript transportvariant// GO:0006811
1, mRNA.
// ion
GO:0005886
transport// GO:0006816
plasma////calcium
GO:0005891
membrane// ion
GO:0006816
GO:0005244
transport// //GO:0005891
voltage-gated//voltage-gated////calcium
GO:0006874
GO:0005245//ion
calcium
GO:0005891○transport
ion//channel//GO:0007214
channel
GO:0005245// //cellular
activity
GO:0045202
complex//calcium//GO:0007528
GO:0005262
voltage-gated// voltage-gated//ion
GO:0005
homeos//cal//GG
NM_001001182
Baz2b
bromodomain
NM_001001182
adjacent toRefSeq
zinc finger domain,
Mus musculus
2B
bromodomain
TRUE
407823
adjacentMm.228071
to zinc finger
A0PJF0domain, 2Bchr2(Baz2b), mRNA.
GO:0008150biological_process
GO:0005575cellular_component// GO:0005634
GO:0046872// nucleus
metal// GO:0003674
ion binding○ //// GO:0003677
molecular_function// GO:0008270// DNA bindin
NM_001025093
Atf2
activating transcription
NM_001025093
factor
RefSeq2
Mus musculus activating
TRUE
transcription
11909 Mm.209903
factor 2 (Atf2),
P16951transcript chr2
variant 1, mRNA.
GO:0003151outflow// GO:0006351
tract GO:0005634
morphogenesis// GO:0006355
nucleus// GO:0005634// transcription,// nucleus
GO:0006366
GO:0000980// DNA-templated
GO:0005737// cytoplasm
RNA////GO:0006970
GO:0001077
polymerase////mitochondrion
GO:0005739//○
regulation//II//GO:0006974
distal
GO:0001102
ofenhancer////transcription,
GO:0005741
mitochondrial////GO:0016573
sequence-specific
GO:0003676
DNA-template//outer
GO:0016memb////GG
NM_001111289
Caprin1cell cycle associated
NM_001111289
protein
RefSeq1
Mus musculus cell
TRUE
cycle associated53872protein
Mm.427589
1 (Caprin1),
Q60865transcript
chr2variant 2,GO:0017148
mRNA.
negative// GO:0030154
regulation
GO:0000932//of
GO:0050775
translation
cytoplasmic// GO:0005737////cell
GO:0061003
mRNA
GO:0003723
differentiation// processing
GO:0010494
RNA////GO:0017148
GO:0044822// binding
positive
body// GO:0010494○// regulation//cytoplasm
poly(A)////GO:0017148
GO:0003723
RNAof////dendrite
GO:0042995
cytoplasmic
binding//morphogenesis
GO:0003723// RNA
stress// GO:0000
binding
granul//NM_001145824
Hipk3
homeodomain
NM_001145824
interactingRefSeq
protein kinaseMus
3 musculus homeodomain
TRUE
15259
interacting
Mm.257925
protein kinase
Q9ERH73 (Hipk3),
chr2transcriptGO:0000122
variant 2, mRNA.
negative// GO:0006351
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0005634//fromnucleus
GO:0006468
GO:0000166
RNA// GO:0005737//
polymerase
cytoplasm
nucleotide////GO:0006468
GO:0003677
II////
promotercytoplasm
binding
GO:0005737○ ////GO:0006915//GO:0003714
DNA
transcription,// PML//binding
GO:0016605
body////DNA-templated
GO:0009299//GO:0004672
nucleustranscription// GO:0005// cytop
//cor
//G
//G
NM_138313 Bmf
BCL2 modifying
NM_138313
factor RefSeq
Mus musculus BCL2
TRUEmodifying
171543factor Mm.210125(Bmf), mRNA.
Q91ZE9chr2
GO:0006915apoptotic// GO:0032464
process
GO:0001669////GO:0043276
positive
acrosomal// GO:0005737
regulation// vesicle
GO:0090200
GO:0005515
of protein////GO:0015629
cytoplasm
homooligomerization
protein// GO:2001234//
binding//actin
GO:0016459○ cytoskeleton// GO:2001235// anoikis// GO:0016459// myosin// //positive
GO:0043276
complexregulation// GO:0001// //myGoNM_001081133
Kif16bkinesin familyNM_001081133
member 16B
RefSeq
Mus musculus kinesin
TRUE family member
16558 Mm.251934
16B (Kif16b),
B1AVY7
mRNA. chr2
GO:0001704formation// GO:0001919
of primary
GO:0005622// GO:0006810
germintracellular
layer// GO:0005623// //regulation
GO:0006895
GO:0000166// cell// //of
GO:0005737
cytoplasm
receptor
nucleotide////GO:0007018
GO:0003777
recycling// //endosome
binding
GO:0005768○ //////
transport
GO:0007173//GO:0005524
microtubule// early// GO:0005769//endosome
Golgi//motor//GO:0007492
to
GO:0005547
endosome
activity////cytoskeleto
GO:0005////tran
AT//GG
NM_177586 Eif5a2
eukaryotic translation
NM_177586
initiation
RefSeqfactor 5A2
Mus musculus eukaryotic
TRUE
translation
208691 initiation
Mm.193670
factorQ8BGY25A2 (Eif5a2),
chr3
mRNA. GO:0006412translation// GO:0006414//GO:0005634
translational// GO:0006452
nucleuselongation// GO:0005643// nuclear
GO:0006810
GO:0003723// translational//pore
GO:0005737//RNA//cytoplasm//frameshifting
GO:0008284
GO:0003746
binding// GO:0005783○////endoplasmictranslation//////transport
GO:0008612
GO:0043022// elongation
GO:0016020
reticulum// positive// GO:0015031
factorregulation// membrane// GO:0005
activity
of
// ce
G//
NM_027016 Sec62
SEC62 homolog
NM_027016(S. cerevisiae)
RefSeq
Mus musculus SEC62
TRUE homolog
69276(S. cerevisiae)
Mm.26017(Sec62),
Q8BU14mRNA.
chr3
GO:0006620posttranslational// GO:0006810
GO:0005622
protein// GO:0015031
targetingintracellular// GO:0005623
to// membrane
GO:0006620
GO:0008565// cell// //GO:0005783
endoplasmic// proteintransport////GO:0006620
GO:0003674
transporter//reticulum//GO:0016020
protein○activitytransport// membrane// //GO:0016021
molecular_function// posttranslational// integral// GO:0005
componeprote
NM_001098170
Pcdh10
protocadherinNM_001098170
10
RefSeq
Mus musculus protocadherin
TRUE
10
18526
(Pcdh10),
Mm.242644
transcript
E9PX28variant 1, chr3mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007155
plasma//cell
GO:0005887
adhesionmembrane// GO:0007156
GO:0005509////cell//
GO:0016020
integraladhesion
calcium// GO:0005515
component//ion//homophilic
GO:0016021
binding○ of plasma//cellproteinadhesionmembranebinding // membrane
NM_177855 Med12l
mediator complex
NM_177855
subunitRefSeq
12-like
Mus musculus mediator
TRUE complex
329650subunitMm.240059
12-like (Med12l),
Q8BQM9mRNA.
chr3
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0006357
nucleus// GO:0016592// regulation// mediator
GO:0006366
GO:0001104
of transcription,complex
RNA////GO:0008150
GO:0008013
polymerase
DNA-templated○ II// transcription
GO:0008134// regulation
cofactorof transcription
activity // be
NM_178892 Tiparp
TCDD-inducible
NM_178892
poly(ADP-ribose)
RefSeq polymerase
Mus musculus TCDD-inducible
TRUE
99929
poly(ADP-ribose)
Mm.246398polymerase
Q8C1B2 (Tiparp),
chr3
mRNA.
GO:0001570vasculogenesis// GO:0001822
GO:0005634// //kidney
GO:0006471
nucleusdevelopment// GO:0005634// nucleus
GO:0006807
GO:0003950// protein ADP-ribosylation
NAD+////GO:0008209
GO:0003950
ADP-ribosyltransferase○ ////GO:0008210
nitrogen
GO:0016740
compoundactivity////GO:0008585
GO:0016757//metabolic
NAD+ ADP-r
proc////GGENSMUST00000119109
Etv3
ets variant 3 ENSMUST00000119109
ENSEMBL havana:known chromosome:GRCm38:3:87525407:87540156:1
TRUE
27049 Mm.219460 Q8R4Z4// Mm.446456
chr3
gene:ENSMUSG00000003382// Mm.457227
GO:0000122negative// GO:0006351
gene_biotype:protein_coding
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0017053//fromtranscriptional
GO:0006357
transcript_biotype:protein_coding
GO:0000981
RNA polymerase
sequence-specific//repressor//GO:0006366
GO:0003677
II promoter
complex○ ////DNA
GO:0030154//GO:0003700
transcription,binding RNA////DNA-templated
GO:0006366
GO:0005515
polymerase //
II//G
tra
//G
NM_008231 Hdgf
hepatoma-derived
NM_008231
growthRefSeq
factorMus musculus hepatoma-derived
TRUE
15191
growthMm.292208
factor (Hdgf),
P51859mRNA. chr3
GO:0000122negative// GO:0006351
regulation
GO:0005615//of
GO:0006355
transcription
extracellular// GO:0005615//from
GO:0006366
GO:0000166
space
RNA
// //GO:0005634
polymerase
extracellular
nucleotide////GO:0009987
GO:0001106
II space//
promoterbinding
GO:0005634○ //////nucleus
GO:0034504//GO:0001222
RNAtranscription,//polymerase//
GO:0005737
nucleus////DNA-templated
GO:0045944
GO:0003677//II cytoplasm
transcription// GO:0017
////G
//G
NM_001029890
Mex3a
mex3 homolog
NM_001029890
A (C. elegans)
RefSeq
Mus musculus mex3
TRUEhomolog 72640
A (C. elegans)Mm.275154(Mex3a),G3UYU0mRNA. chr3
GO:0008150biological_process
GO:0005575cellular_component
GO:0044822poly(A)// GO:0046872
RNA○binding// GO:0003723// metal ion binding// GO:0008270// RNA bind
NM_001165948
Pogz
pogo transposable
NM_001165948
element
RefSeqwith ZNF domain
Mus musculus pogo
TRUEtransposable
229584element
Mm.274787
with ZNF
Q8BZH4domain (Pogz),
chr3 transcript
GO:0007049
variant 2, cellmRNA.
// GO:0007064
cycle // GO:0000790
mitotic// sister
GO:0051301
nuclearchromatid// GO:0005634
chromatin// GO:0051382
cohesion
GO:0003676////GO:0005694
nucleus// cell
nucleic////GO:0007064
division
GO:0003677// chromosome
acid// GO:0005737//○
binding
kinetochore////GO:0007064
GO:0046872//// DNA
cytoplasm
assembly// GO:0000790
binding// //GO:0051382//nuclear//mitotic
metal// GO:0000
chromation
sisterbind// Gch
NM_001037737
Arntaryl hydrocarbon
NM_001037737
receptorRefSeq
nuclear translocator
Mus musculus aryl
TRUEhydrocarbon
11863
receptor
Mm.250265
nuclear translocator
P53762 (Arnt),
chr3 transcript
GO:0001666
variant 1, response
mRNA.
// GO:0001666
to hypoxia
GO:0005634// GO:0001892// response
nucleus// GO:0005634
to//hypoxia
nucleus
GO:0006351
GO:0000989////GO:0005667//embryonictranscription
transcription////GO:0006355
GO:0003677
placenta//factor
GO:0005667○
factordevelopment
complex////GO:0007165
binding
GO:0003700////transcription
GO:0005737
transcription// transcription,////GO:0009636
GO:0003705
factorfactor// GO:0005
DNA-teactivity
compl////GG
NM_207205 Igsf3
immunoglobulin
NM_207205
superfamily,
RefSeqmemberMus
3 musculus immunoglobulin
TRUE
78908
superfamily,
Mm.489667
memberQ6ZQA63 (Igsf3), chr3mRNA.
GO:0032808lacrimal gland
GO:0016020
development
membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_181400 Wdr47
WD repeat domain
NM_181400
47 RefSeq
Mus musculus WD
TRUE
repeat domain
99512
47 Mm.285968(Wdr47), mRNA.
Q8CGF6chr3
GO:0007275multicellular// GO:0008150
GO:0005737
organismal development
cytoplasm// GO:0005856//GO:0003674//cytoskeleton
biological_process// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_020265 Dkk2
dickkopf homolog
NM_020265
2 (Xenopus
RefSeqlaevis) Mus musculus dickkopf
TRUE homolog
56811
2 (Xenopus
Mm.103593
laevis)Q9QYZ8(Dkk2), mRNA.
chr3
GO:0007275multicellular// GO:0016055
GO:0005576
organismal// GO:0030178
development
extracellular// GO:0005615// GO:0090090--region// Wnt// //GO:0005576
signaling
extracellular--// GO:0090263
pathway//
space
GO:0005615○// negative// extracellular
GO:0090090
regulation
region// GO:0090263
of Wnt// extracellularsignaling p
NM_019745 Pdcd10
programmedNM_019745
cell death 10RefSeq
Mus musculus programmed
TRUE
cell
56426
deathMm.316473
10 (Pdcd10),
Q8VE70mRNA. chr3
GO:0001525angiogenesis// GO:0006915
GO:0005737// apoptotic// GO:0008284
cytoplasm
process// GO:0005794////GO:0043066//positive
GO:0042803
Golgi//apparatus
GO:0005829
regulation
protein////GO:0043406
GO:0047485//
of cytosol
homodimerizationcell// GO:0005886
proliferation○ ////plasma//GO:0008284
GO:0005515////
membrane
activity
negative
GO:0016020//////GO:0008284
regulation
proteinGO:0042803// membrane// N-terminu
GO:0070of apop////G//G
NM_001162999
Fnip2
folliculin interacting
NM_001162999
protein
RefSeq2
Mus musculus folliculin
TRUE interacting
329679proteinMm.244005
2 (Fnip2),
Q80TD3
mRNA. chr3
GO:0000122negative// GO:0001932
regulation
GO:0005622//of
GO:0006468
transcription
intracellular// GO:0005634//from
GO:0006974
GO:0003674// nucleus
RNA// GO:0005737
polymerase//molecular_function//cytoplasm
GO:0008630
II //promoter
GO:0005737//○cytoplasm// GO:0033138// regulation// GO:0005815
microtubuleof//protein
GO:0000122
organizing
phosphoryla// GO:0005// ce
G
NM_173347 Prune
prune homolog
NM_173347(Drosophila)
RefSeq
Mus musculus prune
TRUEhomolog
229589(Drosophila)
Mm.14155(Prune),Q8BIW1
mRNA. chr3
GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleus// GO:0005737
process// cytoplasm
GO:0004427// GO:0030054// cellinorganic// junction
GO:0016462//diphosphatase
GO:0005737○// cytoplasm// GO:0016787
activity//// GO:0005925
focal //adhesion//pyrophosphatase
GO:0030145 // aG
NM_010432 Hipk1
homeodomain
NM_010432
interactingRefSeq
protein kinaseMus
1 musculus homeodomain
TRUE
15257
interacting
Mm.20827
protein kinase
O889041 (Hipk1),
chr3mRNA. GO:0000122negative// GO:0006351
regulation
GO:0005622//of
GO:0006355
transcription
intracellular// GO:0005634//from
GO:0006468
GO:0000166// nucleus
RNA// GO:0005634
polymerase//nucleotide//nucleus//GO:0007224
GO:0003677
II //promoter//binding
GO:0005737
cytoplasm○ ////GO:0008284//GO:0003714
DNA
transcription,// cytoplasm//binding
GO:0005737////DNA-templated
GO:0009952//GO:0004672//transcription
PML// GO:0016
body ////cor//G//nG
NM_010306 Gnai3
guanine nucleotide
NM_010306
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
314679
binding
Mm.271703
protein (GQ9DC51protein), alphachr3 inhibiting
GO:0006184
3 (Gnai3),GTP
mRNA.
// GO:0006906
catabolic
GO:0005737
process// GO:0007049//cytoplasm
vesicle// GO:0005737
fusion// GO:0007165//GO:0000166
cytoplasm// cell// GO:0005765
cycle//
nucleotide////
lysosomal
GO:0007186//GO:0003924
signal// binding
GO:0005794
transduction○
membrane////GO:0007188//GO:0003924
GTPase//////Golgi
G-protein
GO:0005813
activity
apparatus////GO:0007193
GO:0004871
coupled// GTPase// //GO:0005
receptor
centroso
activ////GG
NM_019550 Ptbp2
polypyrimidine
NM_019550
tract binding
RefSeqprotein 2 Mus musculus polypyrimidine
TRUE
56195
tract binding
Mm.29966
proteinQ91Z31
2 (Ptbp2), mRNA.
chr3
GO:0006376mRNA// GO:0006376
spliceGO:0005634
site selection// GO:0006397
nucleus////GO:0005681
mRNA// spliceosomal
GO:0008380
splice
GO:0000166
site selection
complex
nucleotide////GO:0033119
GO:0003676// mRNAbinding○ //processing//GO:2000177//GO:0003723
nucleic acid// RNA//binding//GO:0033119
GO:0003729
splicing// RNA// negatbin// G
NM_019586 Ube2j1
ubiquitin-conjugating
NM_019586
enzymeRefSeq
E2J 1 Mus musculus ubiquitin-conjugating
TRUE
56228 enzyme
Mm.259095
E2J 1Q9JJZ4(Ube2j1), mRNA.
chr4
GO:0016567protein// GO:0018279
ubiquitination
GO:0005783// GO:0030433// protein
endoplasmic// GO:0016020
N-linked// GO:0016567
GO:0000166
reticulum
glycosylation// GO:0016021//nucleotide//membrane//GO:0018279
via
GO:0004842
asparagine// binding
GO:0005575○// integral////GO:0018279//GO:0005524
ER-associatedubiquitin-protein
component// GO:0005789////of
GO:0030433
GO:0016874
ubiquitin-depende
membranetransferase////acti//ce
GG
XM_006537592
Cnr1
cannabinoid XM_006537592
receptor 1 (brain)
RefSeq
PREDICTED: Mus
TRUE
musculus cannabinoid
12801 Mm.7992
receptorP47746
1 (brain) (Cnr1),
chr4 transcript
GO:0002866
variant X2,positivemRNA.
// GO:0007165
regulation
GO:0005886//ofGO:0007186
acuteplasma//inflammatory
GO:0016020
membrane// GO:0007188
GO:0004871
response// //GO:0016021
membranesignalto////GO:0007568
antigenic
GO:0004930
transducer//// integral
GO:0043231
stimulus○ //activity//GO:0007611
component
GO:0004949// signal//// GO:0030424
G-proteintransductionof //membrane//GO:0007613
GO:0008144
coupled// GO:0030////G-prote
receptointrace////GG
NM_178756 E130309F12Rik
RIKEN cDNANM_178756
E130309F12
RefSeqgene
Mus musculus RIKENTRUE cDNA272031
E130309F12
Mm.299460
gene (E130309F12Rik),
Q8BFZ2chr4 mRNA. GO:0007399nervous// GO:0007399
system
GO:0016020
development// GO:0008152
membrane// GO:0016021// nervous//GO:0003824
integralsystem// GO:0005575
component
development
catalytic ofactivity
membrane○// metabolic// process
cellular_component
NM_139309 Fktn
fukutin
NM_139309 RefSeq
Mus musculus fukutin
TRUE (Fktn),246179
mRNA. Mm.247210 Q8R507
chr4
GO:0001764neuron// GO:0008285
migration
GO:0005634// GO:0046329
negativenucleus// GO:0005783
regulation// endoplasmic
GO:0060049
GO:0016740
of cell// GO:0005794
proliferation
reticulumtransferase////GO:0008152
GO:0043842//////negative
GO:0005794
activity
Golgi○ //apparatus
GO:0008285
regulation// Kdo//transferase
GO:0005801//ofGolgi
JNK// GO:0008285
apparatus
cascadeactivity// GO:0016////regu//cisGENSMUST00000107415
Zfp618zinc finger protein
ENSMUST00000107415
618 ENSEMBL ensembl_havana_transcript:known
TRUE
72701chromosome:GRCm38:4:62965573:63139708:1
Mm.26479 //Q80YY7
Mm.482416chr4
GO:0006351
gene:ENSMUSG00000028358
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleusgene_biotype:protein_coding// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
transcript_biotype:protein_coding
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr4
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_172698 Efcab14
EF-hand calcium
NM_172698
bindingRefSeq
domain 14 Mus musculus EF-hand
TRUE calcium
230648binding
Mm.283565
domain 14
Q8BGQ6(Efcab14), chr4mRNA.
GO:0008150biological_process
GO:0005575cellular_component
GO:0046872metal// GO:0003674
ion binding○ //// GO:0005509
molecular_function // calcium ion
ENSMUST00000106283
Rims3
regulating synaptic
ENSMUST00000106283
membrane
ENSEMBL
exocytosis
havana:known
3
chromosome:GRCm38:4:120861777:120896579:1
TRUE
242662 Mm.192502 Q80U57// Mm.388896
chr4//gene:ENSMUSG00000032890
Mm.396765
GO:0006810// Mm.479706
transport// GO:0006836////
gene_biotype:protein_coding
Mm.489236
neurotransmitter
GO:0005623// GO:0006887
cell// GO:0030054
transport// cell// junction
GO:0017156
GO:0044325//transcript_biotype:protein_coding
exocytosis// //GO:0045202
synapseion////GO:0042391//channel
GO:0005515
calciumbinding○
ion-dependent// GO:2000300// protein
exocytosis
binding// GO:2000300// regulation o
NM_018774 Phc2
polyhomeotic-like
NM_018774
2 (Drosophila)
RefSeq
Mus musculus polyhomeotic-like
TRUE
54383
2 (Drosophila)
Mm.490300(Phc2),Q9QWH1transcript
chr4
variant 1, GO:0007275
mRNA.
multicellular// GO:0007283
GO:0000792
organismal development
heterochromatin// GO:0005634
GO:0003677// spermatogenesis//// nucleus
GO:0005634
DNA// //GO:0005515
nucleusbinding// GO:0031519○//// protein
PcG// GO:0008270
proteinbinding// GO:0031519
complex// zinc// GO:0046872//
ionPcG//binding
GO:0035
protein//
ENSMUST00000084241
Wasf2
WAS proteinENSMUST00000084241
family, member
ENSEMBL2
ensembl_havana_transcript:known
TRUE
242687chromosome:GRCm38:4:133130505:133199756:1
Mm.23566 //Q8BH43
Mm.416453chr4
GO:0001525
gene:ENSMUSG00000028868
angiogenesis// GO:0001667
GO:0001726// ameboidal// GO:0006897
ruffle//cell
GO:0005622
gene_biotype:protein_coding
migration// intracellular// GO:0006928
GO:0003779////endocytosis
GO:0005622// intracellular
actin////GO:0010592
GO:0005515
binding// cellular//transcript_biotype:protein_coding//GO:0005737○
cytoplasm// protein
component////GO:0016601
GO:0032403
binding// //early
GO:0005769
movement
endosome////protein//GO:0030032
GO:0005515// complex//positive//GO:0005
cytoskel
//reg
bin
G
ENSMUST00000105868
Stmn1
stathmin 1 ENSMUST00000105868
ENSEMBL havana:known chromosome:GRCm38:4:134469742:134473499:1
TRUE
16765 Mm.378957 P54227
chr4gene:ENSMUSG00000028832
GO:0007019microtubule// GO:0007052
gene_biotype:protein_coding
depolymerization
GO:0005622// GO:0007275
intracellular// GO:0005737// mitotic// GO:0007399
GO:0005515// transcript_biotype:protein_coding
cytoplasm
spindle// GO:0005829
organization
protein//////GO:0007409
cytosol
GO:0015631
binding// //GO:0005856//○
multicellularcytoskeleton//////
tubulinGO:0030154
GO:0015631
binding
organismal// //GO:0005874
microtubule////GO:0031110
tubulindevelopment////binding
GO:0016
membran// //G
NM_177733 E2f2
E2F transcription
NM_177733
factor 2RefSeq
Mus musculus E2F
TRUE
transcription
242705factorMm.307932
2 (E2f2), mRNA.
P56931
chr4
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007049
nucleus// GO:0005667// regulation// transcription
GO:0051726
GO:0001047
of// GO:0005634
transcription,
factorcore////GO:0072332
GO:0003677
promotercomplex
DNA-templated○binding// nucleus////GO:1990086
GO:0003700// DNA// cellbinding
cycle////GO:0006355
GO:0005515// //regulation
sequence-sp
of
// G
c
NR_030771 Gm13034 SWI/SNF related,
NR_030771
matrix RefSeq
associated, actin
Mus musculus
dependentpredicted
TRUE
regulator geneof chromatin,
62758513034 (Gm13034),
Mm.424988
subfamily a,B2RT32
non-coding
member 5RNA.
chr4
pseudogene --------GO:0003677DNA// GO:0005524
binding○// ATP binding
NM_001159344
Casz1
castor zinc finger
NM_001159344
1
RefSeq
Mus musculus castor
TRUE zinc finger
69743
1 (Casz1),
Mm.233879
transcript
Q9CWL2variant 1,chr4mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005737// regulation// cytoplasm
GO:0008150
GO:0003677
of// GO:0043231
transcription,// intracellular
DNA// GO:0046872
binding
DNA-templated// GO:0005634
membrane-bounded○// metal ion////binding
multicellular
GO:0005737
organelleorganismal////GO:0043
nucleusde
NM_145711 Tox
thymocyte selection-associated
NM_145711 RefSeqhigh mobility
Mus musculus
group box
thymocyte
TRUE
selection-associated252838 Mm.435828
highQ66JW3
mobility groupchr4box (Tox),---mRNA. --GO:0005634nucleus
GO:0003677DNA binding○
NM_001177849
Asphaspartate-beta-hydroxylase
NM_001177849
RefSeq
Mus musculus aspartate-beta-hydroxylase
TRUE
65973 Mm.222206(Asph), Q8BSY0transcript variant
chr4 3, mRNA.
GO:0007389pattern// GO:0008285
specification
GO:0005737// GO:0010524
process
cytoplasm// GO:0005783// negative// GO:0018193//GO:0004597
endoplasmic
regulation// GO:0005886
peptide-aspartate//ofreticulum//GO:0031585
cell
GO:0005509
proliferation// GO:0016020//○plasma//beta-dioxygenase//GO:0031647
GO:0005515// positive
membrane// GO:0016021
regulation////GO:0032237
activity
membrane
GO:0016491
of//calcium
GO:0030// calcium////inte//G
ioG
NM_026893 Dcaf12
DDB1 and CUL4
NM_026893
associated
RefSeqfactor 12 Mus musculus DDB1
TRUE and CUL4
68970
associatedMm.28891
factor 12
Q8BGZ3(Dcaf12), chr4mRNA.
GO:0008150biological_process// GO:0016567
GO:0005737// protein
cytoplasm// GO:0005813
ubiquitination//GO:0003674
centrosome// GO:0005856
molecular_function// cytoskeleton// GO:0080008○ // Cul4-RING// GO:0005737
E3 ubiquitin// ligase
GO:0005
com
ENSMUST00000157313
Gm26049 predicted gene,
ENSMUST00000157313
26049 ENSEMBL ncrna:known chromosome:GRCm38:4:41312091:41312198:-1
TRUE----Q8BGZ3
chr4
gene:ENSMUSG00000087938----gene_biotype:snRNA----- transcript_biotype:snRNA----○
NM_172381 AI314180 expressed sequence
NM_172381
AI314180
RefSeq
Mus musculus expressed
TRUE
sequence
230249AI314180
Mm.234801(AI314180),
Q6PDI5 mRNA.
chr4
GO:0030433ER-associated
GO:0000502
ubiquitin-dependent
proteasome// GO:0005634
proteincomplex--- catabolic// GO:0005737// nucleus---process////cytoplasm
GO:0005768○// endosome// GO:0005769// early//endosome
GO:0005
NM_144904 Ptbp3
polypyrimidine
NM_144904
tract binding
RefSeqprotein 3 Mus musculus polypyrimidine
TRUE
230257
tract binding
Mm.331640
proteinQ8BHD73 (Ptbp3), transcript
chr4
variant
GO:0006397
1, mRNA.mRNA// GO:0008380
processing
GO:0005634// //GO:0030154
RNAnucleussplicing// //GO:0033119
GO:0000166
cell differentiation
nucleotide////GO:0043249
GO:0003676// negative
binding○ //regulation//GO:0045595//GO:0003723
nucleicofacidRNA//binding//GO:0033119
splicing
GO:0044822// RNA// erythro//binG
NM_172694 Megf9
multiple EGF-like-domains
NM_172694 RefSeq
9
Mus musculus multiple
TRUE EGF-like-domains
230316 Mm.251188
9 (Megf9),
Q8BH27
mRNA. chr4----GO:0016020membrane// GO:0016021//---integral component--of membrane○
ENSMUST00000106061
S100pbp
S100P binding
ENSMUST00000106061
protein ENSEMBL ensembl_havana_transcript:known
TRUE
74648chromosome:GRCm38:4:129148005:129189542:-1
Mm.172064 Q9D5K4// Mm.408391
chr4// Mm.488265
GO:0008150gene:ENSMUSG00000040928
biological_process
GO:0005634nucleus// GO:0005634
gene_biotype:protein_coding// nucleus
GO:0048306calcium-dependent// GO:0048306
transcript_biotype:protein_coding○
protein binding // calcium-depend
NM_175306 Phactr4
phosphataseNM_175306
and actin regulator
RefSeq4
Mus musculus phosphatase
TRUE
and100169actinMm.158361
regulator 4 (Phactr4),
Q501J7 transcript
chr4 variant
GO:0001755
1, mRNA. neural// GO:0001843
crest cell
GO:0005622
migration// GO:0007266
intracellular// GO:0005737
neural// tube
GO:0007275
GO:0003779// cytoplasm
closure// GO:0030027//actin//Rho////GO:0007399
lamellipodium
GO:0004864
binding
protein// GO:0042995○
signal// protein//////GO:0030036
transduction
GO:0008157
cellphosphataseprojection// GO:0030027////GO:0043085
multicellular//GO:0071862
inhibitor
lamellipodium
activity
organ////GG
NM_001080819
Arid1aAT rich interactive
NM_001080819
domainRefSeq
1A (SWI-like)Mus musculus AT
TRUE
rich interactive
93760
domainMm.22478
1A (SWI-like)A2BH40(Arid1a),chr4
mRNA. GO:0000122negative// GO:0001843
regulation
GO:0000790//ofGO:0003205
transcription
nuclear// GO:0000790
chromatin//from
GO:0003408
GO:0003677
RNA////GO:0005622
polymerase
nuclearDNA////GO:0006325
GO:0005515
chromatin
bindingII //promoter
GO:0005634○////protein//intracellular//GO:0006337//GO:0016922
neuralbinding// GO:0016514
tube
// //
nucleus//closureligand-dependent//GO:0006338
GO:0031491//// SWI/SNF
cardiac
GO:0016////G
chnG
NM_001163794
Pdik1lPDLIM1 interacting
NM_001163794
kinaseRefSeq
1 likeMus musculus PDLIM1
TRUE interacting
230809kinaseMm.22778
1 like (Pdik1l),
Q8QZR7transcript
chr4variant 2,GO:0006468
mRNA.
protein// GO:0016310
phosphorylation
GO:0005634//nucleus
phosphorylation// GO:0005575// cellular_component
GO:0000166nucleotide// GO:0004672
binding○ // //GO:0004674
protein kinase// activity
GO:0005524// protein// G
NM_001081557
Camta1
calmodulin binding
NM_001081557
transcription
RefSeqactivator
Mus1musculus calmodulin
TRUE
binding
100072transcription
Mm.318846
activator
A2A8911 (Camta1),
chr4 transcript
GO:0006351
variant 1,transcription,mRNA.
// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// GO:0005737// regulation// cytoplasm
GO:0003677
of transcription,
DNA// GO:0003674
binding
DNA-templated○// molecular_function// biological_process
NM_001099299
Ajap1
adherens junction
NM_001099299
associated
RefSeqprotein 1Mus musculus adherens
TRUE
junction
230959associatedMm.318874
proteinA2ALI51 (Ajap1), mRNA.
chr4
GO:0007155cell// GO:0008150
adhesionGO:0005886// biological_process
plasma// GO:0016020
membrane
GO:0003674// //GO:0016021
membranemolecular_function//// integral
GO:0030054○
component// GO:0005575
of membrane// GO:0005// cell ju
NM_001170745
Magi2
membrane associated
NM_001170745
guanylate
RefSeq kinase,MusWWmusculus
and PDZ
membraneTRUEdomain containing
associated50791 2Mm.332231
guanylate kinase,
Q9WVQ1WW andchr5
PDZ domain
GO:0002092
containing
positive//
2 GO:0007165(Magi2),
regulation
GO:0005634
transcript//ofGO:0007399
receptorvariant
nucleus// GO:0005737
internalization
3, mRNA.
// cytoplasm
GO:0008285
GO:0004871// //GO:0005737
signal// cytoplasm
signal////GO:0010976
transduction
GO:0005515
transducer// //GO:0005768○
endosome//activity//nervous
GO:0016482
GO:0019902//////latesystem
GO:0005770
proteinendosome////development
GO:0030336
binding
GO:0030159//// GO:0005//plasma
phosph//////neGm
G
NM_153526 Insig1
insulin induced
NM_153526
gene 1 RefSeq
Mus musculus insulin
TRUE induced
231070gene 1Mm.30221(Insig1), mRNA.
Q8BGI3chr5
GO:0006629lipid// GO:0006641
metabolic
GO:0005783
process// GO:0006695//endoplasmic
triglyceride// GO:0005783// GO:0006991
GO:0005515
metabolicreticulum// GO:0016020
process//protein//endoplasmic
GO:0008202//bindingcholesterol// GO:0016021○reticulum// GO:0008203
biosynthetic////membrane
GO:0032937
process// GO:0010894// integral// response
GO:0005
com// G
NM_008453 Klf3
Kruppel-like factor
NM_008453
3 (basic)
RefSeq
Mus musculus Kruppel-likeTRUEfactor16599
3 (basic)
Mm.439720(Klf3), mRNA.
Q60980chr5
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:1901653
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// cellularbinding//response
GO:0003677// metalto
ion
peptidbind
NM_001190734
Dcun1d4
DCN1, defective
NM_001190734
in cullin RefSeq
neddylation 1,
Musdomainmusculus
containing
DCN1,
TRUE4 defective(S. cerevisiae)
100737in cullin
Mm.220312
neddylation
Q8CCA01, domain chr5
containing 4GO:0008150(S. cerevisiae)
biological_process(Dcun1d4),
GO:0005634
transcript variant
nucleus// GO:0005575
A,//mRNA.
cellular_component
GO:0003674molecular_function○
NM_001122733
Kit
kit oncogeneNM_001122733
RefSeq
Mus musculus kit
TRUEoncogene (Kit),
16590
transcript
Mm.247073
variantP05532
1, mRNA. chr5
GO:0000187activation// GO:0001541
of MAPK
GO:0001669// activity
GO:0002318
acrosomal////GO:0005615
ovarian// vesicle
GO:0002320
GO:0000166
follicle////development
GO:0005622
extracellular
nucleotide////GO:0002327
GO:0002020
space////myeloid
binding
GO:0005737○ ////intracellular//GO:0002371
progenitor//GO:0004672
protease// GO:0005886
cell//bindingcytoplasm//differentiation//GO:0002551
GO:0004713// protein// GO:0005// plasma//kinas//lym//GG
NM_177680 Ythdc1
YTH doma M
M m
m
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17519967
17520815
17522848
17523081
17526130
17528714
17529713
17530930
17530955
17531734
17533416
17535208
17535241
17538018
17538395
17538658
17539828
17541343
17543840
17544102
17544939
17545078
17545618
17545629
17546834
17547616
17547837
17547846
17548283
17548518
17548946

58.33921
472.654192.6177
65.08034
354.3606
242.9754
466.7708
54.65099
979.2015
32.60688
664.2457
564.8925
106.2006
15.7973
11.10096
27.2250128.17557
22.6035
13.13452
52.66202
251.5343
69.16832
50.85996
13.46382
749.3524
663.49495.57313
99.60606
1204.558
1303.143
1054.596

63.36783
686.8726
257.2575
40.75385
396.8731
249.4519
529.5917
59.80752
842.2397
28.00312858.501
546.4041
151.5649
16.62154
10.32762
22.67239
25.36139
20.2030712.28752
66.44284
267.6529
93.64679
41.40395
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1081.035
810.2198
88.08841
94.7348
1613.575
1200.466
1431.395

0.920644
0.6881247
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1.0338365
0.7006939
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1.1109632
1.1188151
1.0689317
0.7925913
0.939778
0.7386086
1.2283842
0.8490062
0.6931805
0.8189062
1.0849683
1.051420.746515
1.085531
0.736761-0.119285-0.539258-0.417473
0.6752854-0.16346-0.037951-0.182166-0.130079
0.2173749
0.2195888-0.370103
0.048008-0.513144-0.073376
0.1041766
0.2639961
0.151811
0.1619716
0.0961697-0.335351-0.089608-0.437118
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0.1176529
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0.1184009-0.440731

0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 mainNM_011627 Tpbg
trophoblast glycoprotein
NM_011627 RefSeq
Mus musculus trophoblast
TRUE
glycoprotein
21983 Mm.20864(Tpbg), transcript
Q9Z0L0variant
chr9
1, mRNA. ----GO:0005737cytoplasm// GO:0005783//--endoplasmic// GO:0016020---reticulum// GO:0016021//○membrane ////GO:0005886
integral component of me
NM_001100451
Msl2
male-specificNM_001100451
lethal 2 homolog
RefSeq(Drosophila)
Mus musculus male-specificTRUE
lethal77853
2 homolog
Mm.326206(Drosophila)
Q69ZF8// Mm.436586(Msl2),
chr9mRNA. GO:0043984histone// GO:0043984
H4-K16
GO:0072487
acetylation
MSL////GO:0072487
histonecomplex
GO:0008270
H4-K16// MSL// GO:0072487
acetylation
complexzinc// GO:0008766
ion// binding
MSL○complex////UDP-N-acetylmuramoylalanyl-D-gl
GO:0016874 // GO:0018169 // G
NM_001048146
Azi2
5-azacytidineNM_001048146
induced gene
RefSeq2
Mus musculus 5-azacytidine
TRUE
induced27215 gene
Mm.92705
2 (Azi2),
Q9QYP6transcript variant
chr9 2, mRNA.
GO:0000278mitotic// GO:0001816
cell cycle
GO:0005737// cytokine
GO:0007249
cytoplasm// production
GO:0005737// GO:0032607//GO:0005515
cytoplasm// I-kappaB// GO:0005739//
protein// mitochondrion
kinase/NF-kappaB
GO:0032609
binding// GO:0005886○ //// GO:0032635
plasmasignaling
membrane// interferon-alpha// GO:0032640 prod// G
NM_007397 Acvr2b
activin receptor
NM_007397
IIB
RefSeq
Mus musculus activin
TRUE receptor11481
IIB (Acvr2b),
Mm.390239
mRNA.
P27040chr9
GO:0001501skeletal// GO:0001501
system
GO:0005623
development// GO:0001702
cell// GO:0005737//// cytoplasm
skeletal// GO:0001822
GO:0000166
system// GO:0005886
plasmadevelopment
nucleotide////GO:0001822
membrane
GO:0004672// binding
GO:0016020//○gastrulation// //membrane//GO:0001946//GO:0004674
protein//with
GO:0016021
kinase// mouth
integral////GO:0001974
activity
GO:0004674
formingcomponent// GO:0043// second
protein////of
GG
NM_007619 Cbl
Casitas B-lineage
NM_007619
lymphoma
RefSeq
Mus musculus Casitas
TRUE B-lineage12402
lymphoma
Mm.266871(Cbl), P22682
mRNA.
chr9
GO:0007166cell// GO:0014068
surface receptor
GO:0005634// GO:0023051
signaling
nucleus// GO:0005737
pathway// cytoplasm
GO:0043066
GO:0001784// positive// GO:0005886// plasma
regulation
phosphotyrosine////GO:0006468
GO:0004842
membrane//ofGO:0016020○
phosphatidylinositol//
binding//GO:0014068//GO:0004871
membrane// ubiquitin-protein
GO:0016600
3-kinase//////GO:0016567
flotillin
GO:0005509//
signaling
complex
GO:0005transferas////G//G
NM_001253862
Tcf12
transcription NM_001253862
factor 12
RefSeq
Mus musculus transcription
TRUE
factor21406
12 (Tcf12),
Mm.171615
transcript
Q61286variant chr9
2, mRNA. GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005667// regulation// transcription
GO:0007399
GO:0003677
of// GO:0005634
transcription,
factorDNA////GO:0010628
GO:0003700
complexbinding
DNA-templated○////sequence-specificnucleus////GO:0030154
GO:0005515// multicellular////DNA
GO:0045666
GO:0035497
organismal
binding trans
////G
de
G
NM_001114977
U2surpU2 snRNP-associated
NM_001114977
SURP
RefSeqdomain Mus
containing
musculus U2
TRUE
snRNP-associated67958 Mm.292742
SURP domain
Q6NV83containingchr9(U2surp), transcript
GO:0006396
variant
RNA// 1,
GO:0008150
processing
mRNA.GO:0005634// biological_process
nucleus// GO:0005634// nucleus
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0044822// RNA bin
NM_001042779
Sema3bsema domain,
NM_001042779
immunoglobulin
RefSeqdomainMus(Ig),musculus
short basic
sema
TRUE
domain,domain,secreted,
20347
immunoglobulin(semaphorin)
Mm.4083domain
Q62177
3B (Ig), shortchr9
basic domain,
GO:0007275
secreted,multicellular(semaphorin)// GO:0007399
GO:0005576
organismal
3B//(Sema3b),
GO:0030154
development
extracellular// GO:0016020
transcript
GO:0004872
region// variant
nervous// membrane
1,systemmRNA.
receptordevelopment
activity○// cell differentiation
NM_008138 Gnai2
guanine nucleotide
NM_008138
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
214678
binding
Mm.196464
protein (GP08752protein), alphachr9 inhibiting
GO:0000186
2 (Gnai2),activationmRNA.
// GO:0001973
of MAPKK
GO:0005634// GO:0006184
activity
nucleus// GO:0005737// adenosine// cytoplasm
GO:0007049
GO:0000166
receptor// GO:0005813// centrosome
nucleotide//signaling//GO:0007165
GO:0001664//pathwaybinding
GO:0005829○// cytosol////GO:0007186////
GO:0003924
G-protein
GTP// heterotrimeric// catabolic
GO:0005834
coupled////GO:0007188
GO:0004871
process
G-proteinreceptor// GO:0005// cellbindcom////GcG
NM_016853 Stacsrc homologyNM_016853
three (SH3)RefSeq
and cysteineMusrichmusculus
domain src
TRUEhomology three
20840
(SH3)
Mm.1414and cysteine
P97306rich domainchr9(Stac), mRNA.
GO:0034605cellular// GO:0035556
response
GO:0005737
to heat cytoplasm////intracellular
GO:0005575//GO:0046872
cellular_component
signal transduction
metal// GO:0003674
ion binding○// molecular_function
NM_010028 Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His)
NM_010028 RefSeqbox polypeptide
Mus musculus
3, X-linked
DEAD/HTRUE (Asp-Glu-Ala-Asp/His)
13205 Mm.289662
boxQ62167
polypeptidechrX3, X-linked (Ddx3x),
GO:0002376
mRNA.
immune// GO:0006200
system
GO:0005634
process// GO:0006351
nucleus////ATPGO:0005737
catabolic// cytoplasm
GO:0006355
GO:0000166
process// GO:0005739// mitochondrion
nucleotide//////GO:0006417
transcription,
GO:0003676// binding
GO:0005741○ // //
DNA-templated
mitochondrial//GO:0006915//GO:0003677
nucleic// GO:0005852
acid
outer
////binding//GO:0007059
regulation
GO:0003723
membrane////GO:0010
DNAof trans////bin//eu
GG
NM_001290424
Fmr1
fragile X mental
NM_001290424
retardation
RefSeqsyndrome Mus
1 musculus fragile
TRUE X mental14265
retardation
Mm.3451
syndrome
P35922
1 (Fmr1), chrXtranscript variant
GO:0006810
2, mRNA.
transport// GO:0007417// central
GO:0005634// nervous
GO:0045947
nucleus//system
GO:0005737// development
cytoplasm
GO:0051028
GO:0003723// GO:0005844// polysome//RNAnegative// GO:0005515
binding////regulation
GO:0005845
mRNA○// protein// cap
GO:0008017
of translationalbindingbinding// GO:0005874
complex// microtubule// initiation
GO:0044822// microtubu
GO:0010//bindingmRNA// G
ENSMUST00000096420
Styx
serine/threonine/tyrosine
ENSMUST00000096420
interaction
ENSEMBLprotein
havana:known chromosome:GRCm38:X:68821093:68825318:1
TRUE
56291 Mm.202561 Q60969// Mm.434636
chrX
gene:ENSMUSG00000071748
GO:0006470protein// GO:0007283
dephosphorylation
gene_biotype:protein_coding
GO:0005737// GO:0016311
cytoplasm// GO:0005634
spermatogenesis// GO:0045204//transcript_biotype:protein_coding
GO:0004721
nucleus // dephosphorylation
phosphoprotein////GO:0070372
GO:0005515○ phosphatase//// GO:0008138
MAPK export
activityfrom// GO:0016787// nucleus
protein bindin// reg// G
NM_013724 Nrk
Nik related kinase
NM_013724 RefSeq
Mus musculus Nik
TRUE
related kinase
27206(Nrk),
Mm.482319
mRNA. Q9R0G8
chrX
GO:0006468protein// GO:0007256
phosphorylation
GO:0005737// GO:0007567//cytoplasm
activation// GO:0005737// GO:0008285
of//GO:0000166
cytoplasm
JNKK activity
nucleotide////GO:0016310//
GO:0004672
parturition
binding○ ////GO:0023014
negative//GO:0004672
proteinregulation
kinase////GO:0035556
activity
GO:0004674
of cell //proliferat
protein////GG
NM_001033795
Zcchc16
zinc finger, CCHC
NM_001033795
domainRefSeq
containing Mus
16 musculus zinc
TRUE
finger, CCHC
619287
domainMm.387961
containing
Q3URY016 (Zcchc16),
chrX mRNA. GO:0008150biological_process
GO:0005575cellular_component
GO:0003676nucleic// GO:0008270
acid ○
binding// GO:0046872// zinc ion binding// GO:0003674// metal ion b
NM_001271678
Wnk3
WNK lysine deficient
NM_001271678
protein
RefSeqkinase 3 Mus musculus WNK
TRUElysine deficient
279561 protein
Mm.441474
kinaseQ80XP93 (Wnk3), transcript
chrX
variant
GO:0006468
1, mRNA.
protein// GO:0010765
phosphorylation
GO:0005737// GO:0010800//cytoplasm
positive// GO:0005912//regulation
GO:0016310//GO:0000166
adherens// of
GO:0005923
sodiumjunction
nucleotide////GO:0032414
GO:0004672
ion// transport//
tightbinding
GO:0005737○junction////GO:0043066////GO:0004674
positive
protein// cytoplasm
kinaseregulation////GO:0046777
activity
GO:0005524
of peptidyl-thr// protein////GG
NM_019461 Usp27x
ubiquitin specific
NM_019461
peptidase
RefSeq27, X chromosome
Mus musculus ubiquitin
TRUE specific54651
peptidase
Mm.483107
27, X chromosome
Q8CEG8// Mm.491689(Usp27x),
chrX
mRNA.
GO:0006508proteolysis// GO:0006511//GO:0005575
ubiquitin-dependent
cellular_component
proteinGO:0008233
catabolicpeptidase
process// GO:0008234
activity○ //// GO:0016787
cysteine-type peptidase// GO:0036459
activity// G/
NM_001290708
Smarca1
SWI/SNF related,
NM_001290708
matrix RefSeq
associated, actin
Mus musculus
dependentSWI/SNF
TRUE
regulator of
related,chromatin,
93761
matrixMm.229151
subfamily
associated,
a,Q6PGB8
memberactin dependent
1 chrX regulator
GO:0000733
of chromatin,
DNA// GO:0006200
subfamily
strand renaturation
GO:0000790
a, member// GO:0006338
nuclear//1//ATP(Smarca1),
GO:0005634
catabolicchromatin// GO:0006351
GO:0000166
transcript
process////GO:0016589
nucleusvariant
nucleotide//////GO:0006355
chromatin
GO:0003676
// 2,
NURF
//mRNA.
binding
GO:0090537○remodelingcomplex////GO:0007420//GO:0003677
nucleic// //CERF// GO:0005634
transcription,
acidcomplex//binding//GO:0007420
GO:0003682
DNA-templa//////GO:0005
nucleus
DNA//bin//GG
NM_001077354
C77370expressed sequence
NM_001077354
C77370
RefSeq
Mus musculus expressed
TRUE
sequence
245555C77370
Mm.381907(C77370),
Q5DTT1
mRNA.chrX
GO:0000084mitotic// GO:0006287
S phase
GO:0005634////base-excision
GO:0006297
nucleus// GO:0043625
repair,// delta
GO:0007275
GO:0003887
gap-filling
DNA// GO:0005634
polymerase
DNA-directed////GO:0007346
nucleotide-excision
GO:0008408
complex// GO:0043625○DNA//////
GO:0007399
polymerase
GO:0003887
nucleusrepair, DNA// activity
delta////gap
GO:0043137
GO:0008408
DNA
filling// 3'-5'
polymerase//exonucmultic// G
ENSMUST00000150434
Brwd3
bromodomain
ENSMUST00000150434
and WD repeat
ENSEMBLdomainensembl_havana_transcript:novel
containing 3 TRUE
382236chromosome:GRCm38:X:108737016:108834348:-1
Mm.426127 A2AHJ4// Mm.100112
chrX// Mm.404226
GO:0007010// Mm.404234
gene:ENSMUSG00000063663
cytoskeleton// GO:0008360// Mm.413432
GO:0005575
organization// GO:0007010
cellular_component// regulation
gene_biotype:protein_coding// GO:0008360
GO:0005515
of cell shapeprotein//////
GO:0007010
GO:0003674
cytoskeletonbindingtranscript_biotype:protein_coding○ ////organization
molecular_function
GO:0008360// regulation// GO:0008150
of cell sha
NM_001077364
Tsc22d3
TSC22 domain
NM_001077364
family, member
RefSeq3
Mus musculus TSC22
TRUE domain14605
family, Mm.22216
member 3 (Tsc22d3),
Q9Z2S7 transcript
chrX variant
GO:0000122
1, mRNA.negative// GO:0006355
regulation
GO:0005634//of
GO:0006970
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0048642
GO:0003700
RNA// GO:0005634
polymerase// nucleus
sequence-specific////GO:0070236
GO:0043426
II////
promotercytoplasm
GO:0005737○ // DNA
GO:0007589// regulation
binding transcriptionof transcription,
factorDNAac
NM_019496 Ammecr1 Alport syndrome,
NM_019496
mental RefSeq
retardation, midface
Mus musculus
hypoplasia
AlportTRUE
andsyndrome,
elliptocytosis
56068
mentalchromosomal
Mm.143724
retardation,
Q9JHT5regionmidfacegenehypoplasia
chrX
1
andGO:0008150
elliptocytosis
biological_process
chromosomal
GO:0005575
region gene
cellular_component
1 (Ammecr1),
GO:0003674
mRNA.molecular_function○
XM_006528794
Ptchd1
patched domain
XM_006528794
containing
RefSeq1
PREDICTED: Mus
TRUE
musculus211612
patchedMm.218811
domain containing
Q14B62
1 (Ptchd1),
chrX transcript
GO:0007224
variant X2,
smoothened//mRNA.
GO:0050890
GO:0005886
signaling// GO:0007224
pathwayplasma// GO:0016020//membranecognition// GO:0050890
GO:0008158//////
GO:0016021
smoothened
membranehedgehog// GO:0003674//
signaling//receptor
integral
GO:0005886○
pathway
component
activity ////molecular_function
cognitionof membrane // plasm
NM_011077 Phex
phosphate regulating
NM_011077
endopeptidase
RefSeqhomolog,
Mus musculus
X-linked
phosphate
TRUE
regulating
18675 endopeptidase
Mm.2529 P70669
homolog, X-linked
chrX (Phex),
GO:0006508
mRNA. proteolysis// GO:0019637//GO:0005783
organophosphate// GO:0030282
endoplasmic// GO:0005794
metabolic// GO:0031214
GO:0004222
reticulum
process// GO:0016020//metalloendopeptidase//Golgi////GO:0006508
bone
GO:0008233
apparatus
mineralization// GO:0016021○ // membrane
GO:0008237
activity// biomineral// GO:0048471////peptidase
integral// GO:0016787
tissuecomponent
activity
developme//// G
NM_012008 Ddx3y
DEAD (Asp-Glu-Ala-Asp)
NM_012008 RefSeq
box polypeptide
Mus 3,
musculus
Y-linkedDEAD
TRUE (Asp-Glu-Ala-Asp)
26900 Mm.302938
box polypeptide
Q620953, Y-linked
chrY (Ddx3y),
GO:0006200
mRNA. ATP// GO:0008152
catabolic
GO:0005634
process //nucleus
metabolic// GO:0005737// process
cytoplasm
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0004386// RNA bin// G------X91866
GenBank M.musculus mRNA
TRUE
for H3.3A--- variant --histone.
P84244
chr11
GO:0006334nucleosome// GO:0007420
GO:0000786
assembly// GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr3
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_001081019
Gm12657 predicted gene
NM_001081019
12657 RefSeq
Mus musculus predicted
TRUE
gene
66725012657 (Gm12657),
Mm.449778 P84244
mRNA.
chr6
------------○
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr1
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDGSupplementary Table 4. The comparison of global mRNA expression in Mir221/222AdipoKO and Mir221/222flox/y mice fed with high fat-high sucrose (HFHS) chow.
m
Test

m
O

Controlm
Feature ID
Probe Set IDExpression value
Expression{HFHSvalue
Ratio
AdipoKO{HFHS
384}
Log2Ratio
flox/y 388} 解析対象 Flag
category
17211066 13.61456 10.85042 1.2547496 0.3273995
0 main17211305 51.30147 47.63595 1.0769486 0.1069494
0 main17211548 27.61715 28.53265 0.967914 -0.047049
0 main17212947
68.2433 75.26522 0.9067043 -0.141296
0 main17214841 646.7574 470.1974 1.3755019 0.4599581
0 main17215565 94.51138 90.34522 1.0461138 0.0650398
0 main17216888 27.64335 24.47034 1.1296676 0.1758983
0 main17217291
41.8703 51.58801 0.8116285 -0.301109
0 main17217854 97.77634
92.4662 1.0574279 0.0805593
0 main17217901 197.4886 215.3279 0.9171529 -0.124766
0 main17220177 38.61103 25.35535 1.5227962 0.6067229
0 main17220373 233.1286 197.5178 1.1802916 0.2391433
0 main17220489 275.2593 256.9431 1.071285 0.0993424
0 main17221158 17.12076 15.44752 1.1083177 0.1483715
0 main17222440 135.0569 128.7281 1.0491641 0.0692403
0 main17223138 68.90113 81.77136 0.8426071 -0.247068
0 main17223946 18.81731 15.54949 1.2101561 0.2751931
0 main17225373 35.51353 43.87009 0.8095158 -0.304869
0 main17228426 276.9101 309.3543 0.8951228 -0.159842
0 main17229178 132.5691 234.3915 0.5655883 -0.822176
0 main17230469 57.44956 64.60298 0.8892711 -0.169305
0 main17230602 156.8367 168.3848 0.9314184 -0.102499
0 main17230668 249.5798 283.7418 0.8796018 -0.185078
0 main17230760 73.05361 51.96034 1.4059494 0.4915447
0 main17231461 208.4178 215.5273 0.9670135 -0.048392
0 main17232483 14.57383 15.28952 0.9531908 -0.069163
0 main17232734 147.3443 169.2554 0.8705442 -0.200011
0 main17233437 211.5285 198.1677 1.0674217 0.0941302
0 main17233457 817.5409 663.1248 1.2328613 0.3020105
0 main17235211 278.3539 219.8713 1.2659856 0.340261
0 main17236182
1561.97 1261.031 1.2386452 0.308763
0 main17236439 15.89399
16.5119 0.9625779 -0.055025
0 main17238449
209.311 193.3304 1.0826595 0.1145796
0 main17238571 271.1223 297.3772 0.9117118-0.13335
0 main17239234 31.84827
28.0104 1.1370159 0.1852524
0 main17240123
12.5492 11.87797 1.0565105 0.0793071
0 main17240226 274.3249 378.1627 0.725415 -0.463121
0 main17241032 383.8727 201.7627 1.902595 0.9279685
0 main17243509 91.19772 82.39014 1.1069009 0.1465261
0 main17245095 322.7195 322.5288 1.0005913 0.0008528
0 main17245188 235.5322 245.1456 0.9607849 -0.057715
0 main17245587 403.3884 439.5294 0.9177734-0.12379
0 main17246268 53.70585 48.08744 1.1168374 0.1594191
0 main17247448 276.1858 286.4043 0.9643214 -0.052414
0 main17247519 145.4549 177.3747 0.8200431 -0.286228
0 main17247533
1021.62 1017.681 1.0038706 0.0055733
0 main17247550 393.5545
413.364 0.9520773 -0.070849
0 main17248213 448.3499
433.511 1.0342296 0.0485565
0 main17248288
156.112 127.1214 1.2280544 0.2963745
0 main17248476 955.1849 1037.724 0.9204614 -0.119571
0 main17253307 193.5559 210.5211 0.9194133 -0.121215
0 main17254933
312.357 283.0973 1.1033556 0.1418979
0 main17255443 204.2556 257.5068 0.7932047 -0.334235
0 main17255727 71.14986 75.58215 0.941358 -0.087185
0 main17255775 84.22844 78.28211 1.0759603 0.1056248
0 main17255828 146.9251 163.7507 0.8972487-0.15642
0 main17256991 46.31411 44.79544 1.0339023 0.0480999
0 main17257235 120.8584 112.4936 1.074358 0.1034748
0 main17257801 61.82838 72.32794 0.854834 -0.226284
0 main17258789 176.7436 174.3007 1.0140154 0.0200796
0 main17261289
50.959 53.34941 0.9551933 -0.066135
0 main17261896 28.72132 26.70852 1.0753617 0.104822
0 main17262055
60.9169 49.51683 1.2302262 0.2989236
0 main17262964 32.02223 31.10429 1.0295117 0.0419602
0 main17266264 723.2512 647.6657 1.1167045 0.1592475
0 main17266498 232.3093 243.4246 0.9543378 -0.067428
0 main17266534 93.77359
109.636 0.8553175 -0.225468
0 main17267632 78.75014 101.3317 0.7771521 -0.363731
0 main17270621 249.5549 236.9771 1.053076 0.0746096
0 main17272095 76.51385 64.37485 1.1885674 0.2492238
0 main17272530 1123.532 986.7911 1.1385713 0.1872246
0 main17273819 249.6144 248.0828 1.0061737 0.0088794
0 main17277017 39.39758
39.7174 0.9919476 -0.011664
0 main17277177 46.78327 52.09187 0.8980916 -0.155066
0 main17277387 173.6935
115.658 1.5017854 0.5866787
0 main17277521 71.07616 74.09139 0.9593039-0.05994
0 main17279210 330.2432 355.8349 0.9280798 -0.107679
0 main17280913 105.5651 210.4908 0.5015188 -0.995624
0 main17281228 392.2571 388.6653 1.0092414 0.0132713
0 main17284839 71.05316 51.56115 1.3780368 0.4626144
0 main17286595 351.2864 342.7743 1.024833 0.0353888
0 main17286962 584.5587
470.676 1.2419556 0.3126136
0 main17286998 41.44395 38.23375 1.0839625 0.1163148
0 main17287144 44.87271 44.78688 1.0019164 0.0027621
0 main17289196 65.10943 82.20768 0.7920115 -0.336407
0 main
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2Up
2Down

Ratio flag

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KeywordGene Accession
Gene SymbolGene Description
mRNA Accession
mRNA Source
mRna - Description
mRNA - xhybEntrezGene ID
UniGene ID SwissProt accession
ChromosomeGO BiologicalGO
Process
Biological
IDGO
Process
CellularTerm
Component
GO Cellular ID
Component
GO MolecularTerm
GO
Function
Molecular
IDmiR221/222
Function Termtarget gene
NM_177722 Mcmdc2
minichromosome
NM_177722
maintenance
RefSeqdomainMuscontaining
musculus
2 FALSEminichromosome
240697maintenance
Mm.259800
domainE9Q956containing
chr1
2 (Mcmdc2),
GO:0006260
mRNA. DNA// GO:0008150
replication
GO:0005575// biological_process
cellular_component
GO:0003677DNA// GO:0005524
binding○// ATP// GO:0003674
binding // molecular_function
NM_053191 Pi15
peptidase inhibitor
NM_053191
15
RefSeq
Mus musculus FALSE
peptidase inhibitor
94227
15 (Pi15),
Mm.442452
mRNA.
Q8BS03chr1
GO:0010466negative regulation
GO:0005576
of peptidase
extracellular
activity
GO:0030414
regionpeptidase inhibitor○
activity
NM_133235 Khdrbs2
KH domain containing,
NM_133235
RNA
RefSeqbinding, signal
Mus musculus
transduction
FALSE
KH domain
associatedcontaining,
170771
2
Mm.336594
RNA binding,
Q9WU01signal transduction
chr1
associated
GO:0006351
2 (Khdrbs2),
transcription,// GO:0006355
mRNA.
GO:0005634
DNA-templated// GO:0009967
nucleus// GO:0005634// regulation// nucleus
GO:0003723
of transcription,
RNA// GO:0005070
binding
DNA-templated○// SH3/SH2// GO:0008143//adaptor
positiveactivity//regulation
GO:0008266// poly(A)of signa// bG
NM_001164566
Spats2l
spermatogenesis
NM_001164566
associated,
RefSeqserine-richMus
2-likemusculus FALSE
spermatogenesis
67198
associated,
Mm.159989
serine-rich
Q91WJ72-like (Spats2l),
chr1transcript
GO:0008150
variantbiological_process
2, mRNA. GO:0005634nucleus// GO:0005730// nucleolus
GO:0044822// GO:0005737// cytoplasm
poly(A) RNA////GO:0043234
protein○bindingcomplex// GO:0005634// nucleus // //nucleolus
GO:0005
NM_010472 Agfg1
ArfGAP withNM_010472
FG repeats 1
RefSeq
Mus musculus FALSE
ArfGAP with FG
15463
repeats
Mm.433409
1 (Agfg1),Q8K2K6
mRNA.
chr1
GO:0001675acrosome// GO:0006810
assembly
GO:0005634// GO:0007275// transport
nucleus// GO:0016023////multicellularcytoplasmic
GO:0007283
GO:0003677// GO:0031410
organismal
membrane-bounded
DNA////GO:0007289
GO:0008060
binding//development
GO:0042995○// ARF////GO:0030154
vesicleGO:0008270
GTPase// spermatogenesis// //GO:0043025
cytoplasmic
activator////GO:0032312
GO:0046872
activity//
vesicle//GO:0043
sperma
// //
zinc
//Gc
NM_133816 Sh3bp4
SH3-domainNM_133816
binding protein
RefSeq4
Mus musculus FALSE
SH3-domain binding
98402 protein
Mm.170983
4 (Sh3bp4),
Q921I6
mRNA.chr1
GO:0006897endocytosis// GO:0008285
GO:0005634// negative// GO:0010508
regulation
nucleus// GO:0005737//ofcytoplasm
GO:0030308
cell
GO:0005092
proliferation// GO:0005905// coated
GDP-dissociation////GO:0032007//
GO:0017016
positive
pit ////GO:0016020○
membraneregulation//inhibitor//GO:0034260
GO:0042802
of////activity
cytoplasmic
autophagy
GO:0031410//////GO:0050790
GO:0005092
Ras//vesicle
negative
GTPase// GO:0070// regu
extra
//bin
//GG
NM_172485 Thsd7b
thrombospondin,
NM_172485
type I, domain
RefSeqcontaining
Mus musculus
7B
FALSE
thrombospondin,
210417type I,Mm.380518
domain containing
Q6P4U07B (Thsd7b),
chr1
mRNA.
GO:0008150biological_process
GO:0016020membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_001160268
Plekha6
pleckstrin homology
NM_001160268
domainRefSeqcontaining,Musfamilymusculus
A member
FALSE
pleckstrin
6
homology
240753domain
Mm.253559
containing,
Q7TQG1
family Achr1
member 6 (Plekha6),
GO:0008150
transcript
biological_process
variant
GO:0005575
2, mRNA.cellular_component
GO:0003674molecular_function○
ENSMUST00000070283
Dennd1b
DENN/MADDENSMUST00000070283
domain containing
ENSEMBL
1B havana:known FALSE
chromosome:GRCm38:1:138963436:139063719:1
329260 Mm.337604 Q3U1T9// Mm.475093
chr1//gene:ENSMUSG00000056268
Mm.394252
GO:0006810// Mm.474921
transport// GO:0015031//
gene_biotype:protein_coding
proteinGO:0005737// transport
GO:0032313
cytoplasm// GO:0031410// regulation// GO:0008150//GO:0005085
cytoplasmictranscript_biotype:protein_coding
of//Rab
GO:0005575
GTPaseguanyl-nucleotide//vesicle//GO:0032851
GO:0017112
activity// cellular_component
GO:0005829○ //////
exchange
biological_process
GO:0043547
GO:0017112// GO:0030136
factor////cytosol//
activity
GO:0032851
GO:0017112// positive////clathrin-c
Rabregulagua
NM_172643 Zbtb41
zinc finger and
NM_172643
BTB domain
RefSeqcontainingMus
41 musculus
homolog FALSE
zinc finger and226470
BTB domain
Mm.119711
containing
Q811F1
41 homolog
chr1(Zbtb41),GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
ENSMUST00000181811
Gm17275 predicted gene,
ENSMUST00000181811
17275 ENSEMBL ensembl_lincrna:known
FALSE chromosome:GRCm38:1:180802568:180809483:1--Mm.322735 P84244// Mm.427935
chr1
GO:0006334
gene:ENSMUSG00000097347
nucleosome// GO:0007420
GO:0000786
assembly// gene_biotype:lincRNA
GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus
transcript_biotype:lincRNA// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
NM_173378 Trp53bp2 transformation
NM_173378
related protein
RefSeq53 binding
Musprotein
musculus
2 FALSEtransformation209456
related protein
Mm.287450
53 binding
Q8CG79proteinchr1
2 (Trp53bp2),
GO:0006915
mRNA. apoptotic// GO:0007049
process
GO:0005634////GO:0007417
cell cycle
nucleus// GO:0005737// central// cytoplasm
GO:0007507
GO:0008134
nervous// GO:0048471// system
perinuclear
transcription////GO:0009792
GO:0017124
development// region
GO:0005634○
factor//of//GO:0010212
binding
GO:0042802
cytoplasm// heart// GO:0005634//development
SH3////nucleus//domain
GO:0045786
GO:0051059////
binding
GO:0005
embryonucleus////G//Gd
NM_001163754
Rab3gap2 RAB3 GTPase
NM_001163754
activatingRefSeq
protein subunit
Mus2 musculus FALSE
RAB3 GTPase98732
activating
Mm.275841
protein subunit
Q8BMG72 (Rab3gap2),
chr1
mRNA.
GO:0043087regulation// GO:0008150
of GO:0005737
GTPase// GO:0043087
activitycytoplasm// GO:0005886// biological_process// GO:0043087//GO:0005096
plasma// GO:0005737
membrane
GTPase//////GO:0043547
regulation
GO:0030234//activator//cytoplasm
GO:0005886○of GTPase
activity// GO:0046982// plasma
activity// enzyme
membrane////regulation
GO:0003674
regulator of
activity
GTPa// G
NM_001290397
Mybl1
myeloblastosis
NM_001290397
oncogene-like
RefSeq1
Mus musculus FALSE
myeloblastosis 17864
oncogene-like
Mm.4791 (Mybl1),
P51960transcript
chr1
variant 2, GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated
nucleus// regulation
GO:0003677
of transcription,
DNA// GO:0003682
binding
DNA-templated○// chromatin binding
NM_019570 Rev1
REV1 homolog
NM_019570(S. cerevisiae)
RefSeq
Mus musculus FALSE
REV1 homolog56210(S. cerevisiae)
Mm.389103(Rev1),
Q920Q2
mRNA. chr1
GO:0006260DNA// GO:0006281
replication
GO:0005634////DNA
GO:0006974
repairnucleus// cellular// GO:0009411
GO:0000287
responsemagnesium//
to//GO:0042276
DNA
GO:0003677
damageion○ binding//stimulus//GO:0006261
GO:0003684// DNA// response
binding////GO:0009411
GO:0003720
to //UV
damaged// error-p// G
D
NM_001163314
Pgap1
post-GPI attachment
NM_001163314
to proteins
RefSeq1
Mus musculus FALSE
post-GPI attachment
241062 toMm.103539
proteins 1 (Pgap1),
Q3UUQ7mRNA.
chr1
GO:0006505GPI// GO:0006506
anchor metabolic
GO:0005783// GO:0006810
process
endoplasmic// GO:0016020// GPI// GO:0006886
GO:0004518
anchorreticulum// GO:0016021
biosynthetic//nuclease//membrane//GO:0007605
GO:0016787
process//activity
GO:0005783○// integral//////GO:0009880
transporthydrolase
GO:0016788
component// GO:0005783//activity
intracellular////of
GO:0009880
GO:0042578
membrane// hydrolase//protein
GO:0005////act
//
tra
en
GG
NM_010154 Erbb4
v-erb-a erythroblastic
NM_010154
leukemia
RefSeqviral oncogene
Mus musculus
homolog
FALSE
v-erb-a4 (avian)erythroblastic
13869 leukemia
Mm.442420
viralQ61527
oncogene homolog
chr1
4 (avian)
GO:0001755(Erbb4),neuralmRNA.
// GO:0006351
crest cell
GO:0005634
migration// GO:0006355
nucleus// GO:0005737
transcription,// cytoplasm
GO:0006468
GO:0000166
DNA-templated// GO:0005739// mitochondrion
nucleotide////GO:0006915
GO:0004672// binding
regulation
GO:0005886○ // //plasma//GO:0007165//GO:0004713
proteinof transcription,
membrane// GO:0005901
kinase////GO:0007169
activity
GO:0004714//DNA-templated
caveola// GO:0014// protein// //pos//GG
NM_010262 Gbx2
gastrulation brain
NM_010262
homeobox
RefSeq2
Mus musculus FALSE
gastrulation brain
14472
homeobox
Mm.204730
2 (Gbx2),
P48031
mRNA. chr1
GO:0001569patterning// GO:0001569
of GO:0005634
blood//vessels
GO:0001755
nucleus// patterning// GO:0006351
GO:0003677
of blood vessels
DNA////GO:0006355
GO:0003700
binding// neural○// crest
sequence-specific////GO:0007411
GO:0043565
cell migration// DNA
GO:0008283// transcription,binding trans// G
D
NM_001039184
Cep350centrosomal NM_001039184
protein 350 RefSeq
Mus musculus FALSE
centrosomal protein
74081350
Mm.260247(Cep350), D3YTP2
mRNA.
chr1
GO:0008150biological_process// GO:0034453
GO:0005634// microtubule
nucleus// GO:0005737
anchoring// cytoplasm
GO:0003674// GO:0005813// centrosome
molecular_function// GO:0008017// GO:0005634○// nucleus// microtubule// cytoplasm// GO:0005737
binding// centrosome// GO:0005
NM_009721 Atp1b1
ATPase, Na+/K+
NM_009721
transporting,
RefSeqbeta 1 Mus
polypeptide
musculus FALSE
ATPase, Na+/K+
11931
transporting,Mm.4550
betaP14094
1 polypeptide
chr1(Atp1b1), mRNA.
GO:0001666response// GO:0001824
to hypoxia
GO:0005886// GO:0006200// blastocyst
plasma// GO:0005890
membranedevelopment// GO:0006810
GO:0005391// //GO:0005901
sodium:potassium-exchanging// ATPsodium:potassium-exchanging////GO:0006811
GO:0005515
catabolic// GO:0016020○process////GO:0006813
GO:0023026// transport// GO:0016021
ATPaseATPase////GO:0006814//GO:0005391
complexionactivity
transport// GO:0016// //caveo
//pro
//G
ENSMUST00000159685
Gm12657 //predicted
Gm6749// ENSMUST00000159685
gene// ENSMUST00000159685
H3f3c
12657
// Gm10257// predicted
ENSEMBL// ENSMUST00000159685// pseudogene
H3f3bhavana:known// H3f3a
6749FALSE
chromosome:GRCm38:1:180810241:180813603:-1// H3 //histone,
ENSMUST00000159685
667250family 3C
Mm.449778// predicted
E0CYN1//// Mm.371797
ENSMUST00000159685
gene 10257
chr1//gene:ENSMUSG00000060743
H3
Mm.371563
histone,GO:0001649//family//ENSMUST00000159685
Mm.315189
3B
osteoblast////GO:0042692
H3 histone,// differentiation
gene_biotype:protein_coding
Mm.375617
GO:0000228
family// GO:1902340
3A//nuclear//Mm.385440//muscle
GO:0000788
chromosome//cell
GO:0006997
GO:0000979
differentiation//transcript_biotype:protein_coding
Mm.427935// GO:0001740// nuclear
RNA////GO:0090230//
GO:0000980//polymerase
negative
Mm.454661
nucleosome// GO:0005634○regulation//II//GO:0006334
core
GO:0031492// Mm.491100
Barr
promoterof// body
chromosome
GO:0043234////sequence-specific//GO:0007420
nucleus//GO:0003677
Mm.491524
condensatio// GO:0070// protein////GDG
NM_175127 Fbxo28
F-box proteinNM_175127
28
RefSeq
Mus musculus FALSE
F-box protein 28
67948(Fbxo28),
Mm.30737
mRNA. Q8BIG4
chr1
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_177389 Mia3
melanoma inhibitory
NM_177389
activity
RefSeq3
Mus musculus FALSE
melanoma inhibitory
338366activity
Mm.41152
3 (Mia3),
Q8BI84
mRNA. chr1
GO:0002063chondrocyte// GO:0002687
GO:0005783
development// GO:0006810
endoplasmic// GO:0005789
positive// GO:0006887
regulation
GO:0003674
reticulum// GO:0005789
of//leukocyte
molecular_function//endoplasmic
GO:0007162//migration
GO:0016020○reticulum// GO:0015031// transport
membrane// GO:0016021//// exocytosis
GO:0016192// endoplasmic// GO:0005// negat// reG
NM_145515 Mark1
MAP/microtubule
NM_145515
affinity-regulating
RefSeq kinase
Mus musculus
1
FALSE
MAP/microtubule
226778affinity-regulating
Mm.7445 Q8VHJ5
kinase 1 (Mark1),
chr1 mRNA.GO:0000226microtubule// GO:0001764
cytoskeleton
GO:0005737// GO:0006468
cytoplasm
organization// GO:0005856// GO:0007010//GO:0000166
cytoskeleton// neuron// GO:0005886
migration
nucleotide//////GO:0016055
GO:0000287
plasma//// protein
binding
GO:0016020
membrane○ ////
phosphorylation
GO:0016310//GO:0001786
magnesium// //membrane
GO:0005737
//ion
////
GO:0035556
GO:0004672
cytoskeletonbinding// cytoplasm// GO:0005// phosp
//org
//G
//G
NM_007956 Esr1
estrogen receptor
NM_007956
1 (alpha)
RefSeq
Mus musculus FALSE
estrogen receptor13982
1 (alpha)
Mm.9213(Esr1),// mRNA.
P19785
Mm.463262 chr10// Mm.489063
GO:0001547antral// GO:0002064
ovarianGO:0005634
follicle// GO:0006351
growthnucleus// GO:0005634// epithelial// nucleus
GO:0006355
GO:0001046
cell//development
GO:0005737// cytoplasm
core////GO:0006357
GO:0003677
promoter////transcription,cytoplasm
GO:0005737○sequence-specific////GO:0006366
GO:0003682// DNA-templated
mitochondrion// GO:0005739
DNA////GO:0007200
GO:0003700
binding////Golgi//regulation
GO:0005//apparDNA////GG
XR_380237 LOC102632938
uncharacterized
XR_380237
LOC102632938
RefSeq
PREDICTED: Mus
FALSE
musculus
102632938
uncharacterized--LOC102632938
Q8BG92
chr10(LOC102632938),--ncRNA.
----------○
NM_001168304
Cdk19
cyclin-dependent
NM_001168304
kinase 19
RefSeq
Mus musculus FALSE
cyclin-dependent
78334
kinaseMm.200924
19 (Cdk19),
Q8BWD8transcript variant
chr10 1, mRNA.
GO:0006468protein// GO:0007049
phosphorylation
GO:0005575// GO:0016310//cellular_component
cell cycle// GO:0051301//GO:0000166
phosphorylation
nucleotide////GO:0051726
GO:0004672// cellbinding
division○ ////GO:0008152//GO:0004674//protein
regulation
kinaseof//cell
activity
GO:0004693
cycle// //protein
metab
// G
NM_001193303
Lims1
LIM and senescent
NM_001193303
cell antigen-like
RefSeq domains
Mus musculus
1
FALSE
LIM and senescent
110829cellMm.57734
antigen-likeQ99JW4
domains 1 (Lims1),
chr10 transcript
GO:0007160
variant cell-matrix
3,//mRNA.
GO:0007163
adhesion
GO:0005886// GO:0016337// establishment
plasma// GO:0005925
membrane// GO:0043009
GO:0005515
or maintenance// //GO:0005925
focal
protein////adhesion
GO:0043066
of
GO:0008270
cellbinding//polarity
GO:0016020//○focal//////
zinc//GO:0045216
adhesion
GO:0046872
singleion//bindingorganismal
GO:0030054// membrane//////
GO:0045892
GO:0008270
metal
cell-cell//ion
GO:0043// celladhesibinding//jun
G
NM_011240 Ranbp2
RAN bindingNM_011240
protein 2 RefSeq
Mus musculus FALSE
RAN binding protein
193862 Mm.431695(Ranbp2), mRNA.
Q9ERU9chr10
GO:0006457protein// GO:0006810
folding
GO:0005634// transport// GO:0015031
nucleus//// GO:0005643
protein// nuclear
GO:0033132
transport
GO:0003723//pore
GO:0005739// negative//RNA//mitochondrion//GO:0046907
GO:0003755
binding
regulation// GO:0016020○// peptidyl-prolyl//////
of
GO:0051028
membrane
GO:0005515
glucokinase// GO:0031965
cis-trans// activity//
nuclear//GO:0090526
GO:0008270
isomerase
membrane//// intracellula
GO:0031//act//GG
NM_021565 Midnmidnolin
NM_021565 RefSeq
Mus musculus FALSE
midnolin (Midn),
59090
mRNA.
Mm.143813 Q3TPJ7
chr10
GO:0033132negative// GO:0046676
regulation
GO:0005634//of
GO:0033132
glucokinase
nucleus// GO:0005730//
activity
nucleolus
GO:0046676
GO:0019900////negative
GO:0005730// nucleolus
kinase// regulation
GO:0019900
binding//// GO:0005829
cytosol○of //insulin
kinase// nucleus
secretionbinding// GO:0005634// nucleolus// negative// GO:0005
regulatio
NM_011595 Timp3
tissue inhibitor
NM_011595
of metalloproteinase
RefSeq 3 Mus musculus FALSE
tissue inhibitor 21859
of metalloproteinase
Mm.4871 P39876
3 (Timp3), mRNA.
chr10
GO:0010466negative// GO:0045861
regulation
GO:0005576//of
GO:0051045
peptidase
extracellular// GO:0005578
activity// GO:0071310
GO:0004857
region// negative// //GO:0005604
proteinaceous
enzyme//regulation//GO:0010951
GO:0008191
inhibitor// GO:0005634
extracellularof○proteolysis//activity//GO:0051045
GO:0030414
matrix////// metalloendopeptidase
GO:0005737
negative// basement// GO:0046872
regulation// GO:0031
membranof inhimem
NM_001128086
Anks1bankyrin repeat
NM_001128086
and sterileRefSeq
alpha motif domain
Mus musculus
containing
FALSE
ankyrin
1B repeat and77531
sterileMm.440605
alpha motif
Q8BIZ1domain containing
chr10 1B (Anks1b),
GO:0008150
transcript
biological_process
variant
GO:0005634
1, mRNA. nucleus// GO:0005737// cytoplasm
GO:0046875// GO:0005886// plasma
ephrin// GO:0046875
receptor
membrane// GO:0016020○ binding// membrane////ephrin
GO:0030054
receptor// cell junction
binding// GO:0042// ce
NM_172790 Ankrd52
ankyrin repeat
NM_172790
domain 52RefSeq
Mus musculus FALSE
ankyrin repeat237615
domain Mm.440177
52 (Ankrd52),
Q8BTI7
mRNA. chr10
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_028873 Dnajc14
DnaJ (Hsp40)
NM_028873
homolog, subfamily
RefSeq C, member
Mus musculus
14 FALSE
DnaJ (Hsp40) homolog,
74330 Mm.296915
subfamily C,
Q921R4member 14
chr10(Dnajc14),GO:0006810
mRNA.
transport// GO:0015031// protein
GO:0005783// transport
GO:0008150
endoplasmic// GO:0016020// biological_process
GO:0001664
reticulum// GO:0016021//G-protein
membrane// GO:0050780//coupled
GO:0005789○// integral
receptor
componentbinding of//membrane
dopamine recep// en
NM_001114333
Grm1
glutamate receptor,
NM_001114333
metabotropic
RefSeq 1 Mus musculus FALSE
glutamate receptor,
14816metabotropic
Mm.4829861P97772(Grm1), transcript
chr10 variantGO:0000186
2, mRNA. activation// GO:0000187
of MAPKK
GO:0005634// GO:0007165
activity
nucleus// GO:0005886// activation// plasma
GO:0007186
GO:0001639
of//membrane
MAPK
GO:0005887
PLC//activity//GO:0007205
GO:0004871
activating// integral// GO:0014069
signal
○ G-protein
component//transduction//GO:0007206
GO:0004930
coupled// GO:0014069
of plasma// //G-protein
glutamate//GO:0007216
GO:0005515
membrane// coupled
GO:0016
receptor//////GrepG
XM_006512693
Clvs2
clavesin 2 XM_006512693
RefSeq
PREDICTED: Mus
FALSE
musculus215890
clavesinMm.94461
2 (Clvs2), transcript
Q8BG92variant
chr10
X1, mRNA.
GO:0006810transport// GO:0007040// lysosome
GO:0005622// GO:0007040
organization
intracellular// GO:0005768// lysosome
GO:0005215// endosome// GO:0005794
organizationtransporter//// Golgi
GO:0008289
apparatus// GO:0005802
activity○ // //GO:0080025//lipidtrans-Golgi//binding
GO:0016020
network//// GO:0080025
phosphatidylinos////GO:0030
membra// G
NM_008538 Marcks
myristoylatedNM_008538
alanine richRefSeq
protein kinaseMus
C musculus
substrate FALSE
myristoylated alanine
17118 rich
Mm.30059
protein kinase
P26645
C substratechr10(Marcks),--- mRNA. --GO:0005737cytoplasm// GO:0005813//GO:0003779
centrosome// GO:0005856
actin//// cytoskeleton
GO:0005080
binding// GO:0005938○// protein////cell
GO:0005515
cortexkinase// GO:0016020//
C membranebinding// GO:0005516//// protein
GO:0042// germin
bin
NM_029083 Ddit4
DNA-damage-inducible
NM_029083transcript
RefSeq 4 Mus musculus FALSE
DNA-damage-inducible
74747 Mm.21697
transcript 4Q9D3F7(Ddit4), mRNA.
chr10
GO:0001666response// GO:0001666
to hypoxia
GO:0005622// GO:0001764// response
intracellular// GO:0005622
to//hypoxia
GO:0006915
GO:0071889// intracellular////GO:0005737
neuron14-3-3// //GO:0007420
migrationcytoplasm
protein// GO:0005739○//binding//
apoptotic//mitochondrion
GO:0008283//
process
GO:0005622//// //GO:0009968
intracellular
brain //developme
GO:0005////cytG
NM_010914 Nfyb
nuclear transcription
NM_010914
factor-Y
RefSeqbeta
Mus musculus FALSE
nuclear transcription
18045factor-Y
Mm.245998
beta (Nfyb),
P63139mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005622
DNA-templated// GO:0045893
intracellular// GO:0005634// regulation// GO:0006355
GO:0003677// nucleusof// GO:0005634
transcription,//DNA
nucleus// GO:0003677
binding
DNA-templated//// GO:0005667
transcription○// DNA// GO:0003700
bindingfactor//// positive
GO:0016602//complex
sequence-specific//regulation
GO:0032403////CCAAT-bin
GO:0005of trans//
DN
G
NM_001037848
Cnot2
CCR4-NOT transcription
NM_001037848
RefSeqcomplex, subunit
Mus musculus
2
FALSE
CCR4-NOT transcription
72068 Mm.351553
complex, subunit
Q8C5L32 (Cnot2),
chr10 transcript
GO:0000122
variant 4,negativemRNA.
// GO:0001829
regulation
GO:0005634//of
GO:0006351
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0006355
GO:0001226
RNA// GO:0030014
polymerase// CCR4-NOT
RNA////GO:0006417
GO:0004535
polymerase
II //promoter
GO:0005737
complex○ //II//GO:0007275//
transcription
GO:0001226//
trophectodermal
cytoplasm// GO:0005737
corepressor//////
GO:0010606
GO:0001226
cytoplasm
cell //differentiati
GO:0030
binding////CC//GG
NM_177798 Frs2
fibroblast growth
NM_177798
factor receptor
RefSeqsubstrate
Mus2musculus FALSE
fibroblast growth327826factorMm.135965
receptor substrate
Q8C1802 (Frs2),
chr10
mRNA. GO:0000187activation// GO:0001702
of MAPK
GO:0005737// activity
GO:0001759
cytoplasm////GO:0005886
gastrulation// GO:0002088//GO:0005068
plasmawith// GO:0005911
membranemouthtransmembrane////GO:0003281
forming
GO:0005104////cell-cell
GO:0016020
second○ receptor////junction
GO:0007169
GO:0005158// organ
protein//induction
membranetyrosine////GO:0007405
GO:0005168// kinaselens develop
adapt////GG
NM_001163024
Mon2
MON2 homolog
NM_001163024(yeast) RefSeq
Mus musculus FALSE
MON2 homolog67074(yeast)Mm.169924(Mon2), transcript
Q80TL7variant
chr10
1, mRNA. GO:0006810transport// GO:0015031// protein
GO:0005802// transport
GO:0016192
trans-Golgi// GO:0005802// vesicle-mediated// GO:0030036
network
GO:0005086// trans-Golgi
transport
ARF////GO:0043087
GO:0005086
guanyl-nucleotide//networkactin○ cytoskeleton// GO:0006895
exchangeorganization//factor
GO:0016192
activity// regulatio// //ARG
NM_011772 Ikzf4
IKAROS family
NM_011772
zinc fingerRefSeq
4
Mus musculus FALSE
IKAROS family22781
zinc finger
Mm.358648
4 (Ikzf4),Q8C208
mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// regulation// GO:0045944
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0005515// DNA// negative
binding// regulation
GO:0042803// protein ofbinding
tran// G
ENSMUST00000154425
Ppp3r1protein phosphatase
ENSMUST00000154425
3, regulatory
ENSEMBL
subunithavana:known
B, alpha isoform
FALSE
chromosome:GRCm38:11:17192844:17195109:1(calcineurin
19058
B, typeMm.41840
I)//Q63810
Mm.401506chr11//gene:ENSMUSG00000033953
Mm.474050
GO:0001569patterning// GO:0001837
gene_biotype:protein_codingof GO:0005622
blood//vessels
GO:0006470
intracellular////GO:0005623
epithelial// GO:0006470
GO:0004721//transcript_biotype:processed_transcripttocellmesenchymal// //GO:0005737
cytoplasm
phosphoprotein////GO:0007507
GO:0004721
transition// //plasma
GO:0005886○ phosphatase////membrane//protein
GO:0034504
GO:0005509//dephosphorylation
GO:0016020
activity// membrane////GO:0051531
GO:0005515// phosphoprote// GO:0042// //sarcole
protein////GG
NM_033523 Spred2
sprouty-related,
NM_033523
EVH1 domain
RefSeqcontaining
Mus2musculus FALSE
sprouty-related,
114716
EVH1 Mm.266627
domain containing
Q924S72 (Spred2),
chr11 mRNA.GO:0000188inactivation// GO:0007275
of
GO:0005634
MAPK// GO:0009966
activity
nucleus// GO:0005737// multicellular// cytoplasm
GO:0010801
GO:0005173//organismal
GO:0005886// plasma
stem////GO:0010801
GO:0005515
celldevelopment
membrane//factor
GO:0016020○ receptor////GO:0043517////
GO:0019901
membraneregulation
binding// GO:0031410
of//////signal
GO:0071901
proteincytoplasmic
GO:0019901
transduction//binding
GO:0005vesic//////GG
ENSMUST00000132285
Rab1
RAB1, member
ENSMUST00000132285
RAS oncogene
ENSEMBLfamilyhavana:known FALSE
chromosome:GRCm38:11:20201439:20219487:1
19324 Mm.271944 P62821// Mm.368433
chr11
gene:ENSMUSG00000020149// Mm.471872
GO:0000045// Mm.486775
autophagic// GO:0006184
gene_biotype:protein_coding// Mm.491009
vacuoleGO:0000139// assembly
GO:0006810
Golgi// GO:0005622//membrane
GTP// GO:0006886
GO:0000166
catabolictranscript_biotype:processed_transcript// intracellular
GO:0005623
process
nucleotide////GO:0006888
GO:0003924////transport//cellbinding
GO:0005737○// cytoplasm//////GO:0006897//GO:0005515
intracellular
GTPase// GO:0005768// endosome
activity
protein////GO:0006914
GO:0005525// transport
protein//// early
GO:0005bindinendo//////GEGENSMUST00000101477
Peli1
pellino 1
ENSMUST00000101477
ENSEMBL havana:known FALSE
chromosome:GRCm38:11:21135469:21150323:1
67245 Mm.28957 //Q8C669
Mm.403029chr11//gene:ENSMUSG00000020134
Mm.408019
GO:0000209// Mm.408628
protein// GO:0001819
polyubiquitination
gene_biotype:protein_coding
GO:0005634// GO:0008063
nucleus// positive// regulation
GO:0030890
GO:0004842
transcript_biotype:protein_codingof cytokine
ubiquitin-protein////GO:0031398
GO:0005515
production○ transferase////GO:0032088//GO:0008766
Toll signaling
activity////GO:0032496
pathway
GO:0016874// protein//binding
positiv////GG
NM_001290676
Cpeb4
cytoplasmic polyadenylation
NM_001290676
RefSeqelement binding
Mus musculus
protein FALSE
4cytoplasmic polyadenylation
67579 Mm.339792
element
Q7TN98binding protein
chr114 (Cpeb4),
GO:0002931
transcriptresponse
variant// GO:0035235
2,tomRNA.
ischemia
GO:0005634// GO:0036294// ionotropic
nucleus// GO:0005634//glutamate
nucleus
GO:0042149
GO:0000166// GO:0005737//
receptorcytoplasm
nucleotide////GO:0043524
GO:0003676
signaling////cytoplasm
binding
GO:0005737○
pathway////GO:0071230//GO:0003723
nucleic////endoplasmic
cellular// GO:0005783
acidresponse//binding//GO:0071230
GO:0044822
reticulum//to//GO:0014
RNA
decrease// //posbin//GG
NM_177364 Sh3pxd2b SH3 and PXNM_177364
domains 2BRefSeq
Mus musculus FALSE
SH3 and PX domains
268396 2B
Mm.227616(Sh3pxd2b),
A2AAY5
mRNA. chr11
GO:0001501skeletal// GO:0001501
system
GO:0002102
development// GO:0001654
podosome// GO:0005737// skeletal// GO:0001654//GO:0010314
cytoplasm
system// GO:0030054
development
phosphatidylinositol-5-phosphate//////cell
GO:0006801
GO:0032266
junction// GO:0042995//○eye// //cell
development//GO:0007507
GO:0035091
projection// GO:0002102////
bindingeyepodosome//GO:0007507
GO:0042169
development// phosphat
GO:0005// cytop////G//G
NM_145962 Pank3
pantothenateNM_145962
kinase 3 RefSeq
Mus musculus FALSE
pantothenate 211347
kinase 3 Mm.255044(Pank3), mRNA.
Q8R2W9 chr11
GO:0015937coenzyme// GO:0016310
A GO:0005737
biosynthetic// GO:0015937
cytoplasm
process// GO:0005737//// GO:0016310//
phosphorylation
GO:0000166
cytoplasm nucleotide// //GO:0004594
coenzyme
binding○ A //biosynthetic//GO:0005524
pantothenate
process//kinase
GO:0016301// activity
phosphoryl//// AG
NM_001024205
Nufip2
nuclear fragile
NM_001024205
X mental retardation
RefSeq protein
Mus musculusinteractingFALSE
nuclearproteinfragile
2
X
68564
mentalMm.428996
retardation Q5F2E7protein interacting
chr11 protein---2 (Nufip2), --mRNA.
GO:0005634nucleus// GO:0005737// cytoplasm
GO:0003723// GO:0042788// polysomal
RNA// GO:0044822
binding//ribosome
GO:0005634○// poly(A)// GO:0003723// nucleus
RNA// GO:0005634
binding// nucleus// GO:0003723// RNA////GO:0005
cytoplasbinding
NM_016686 Vezf1
vascular endothelial
NM_016686
zinc finger
RefSeq1
Mus musculus FALSE
vascular endothelial
22344zinc
Mm.46628
finger 1 (Vezf1),
Q5SXC3mRNA.
chr11
GO:0001525angiogenesis// GO:0001885
GO:0005634// endothelial
nucleus//cell
GO:0005634
development// nucleus
GO:0003676nucleic// GO:0046872
acid ○
binding // metal ion binding
NM_201609 Zfp652
zinc finger protein
NM_201609
652 RefSeq
Mus musculus FALSE
zinc finger protein
268469652 Mm.389038(Zfp652), mRNA.
Q5DU09// Mm.418731
chr11
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_001081434
Osbpl7
oxysterol binding
NM_001081434
protein-like
RefSeq7
Mus musculus FALSE
oxysterol binding
71240
protein-like
Mm.190450
7 (Osbpl7),
A2A716
mRNA.chr11
GO:0006810transport// GO:0006869// lipid
GO:0005776
transport// GO:0071397
autophagic// GO:0005829
cellular// GO:1901800
vacuoleresponse
GO:0015485// GO:0005886//tocytosol
cholesterol
cholesterol////GO:0071397
GO:0015485// plasma// //GO:0097038
binding○
positivemembrane// GO:1901800//regulation
cholesterol// GO:0005776// perinuclearof binding
proteasomal
endoplasmic// GO:0005
protein
NM_138657 Socs7
suppressor ofNM_138657
cytokine signaling
RefSeq7
Mus musculus FALSE
suppressor of 192157
cytokine Mm.34339
signaling 7 (Socs7),
Q8VHQ2mRNA.
chr11
GO:0008286insulin// GO:0009968
receptor
GO:0005634
signaling// GO:0016567
nucleuspathway// GO:0005730////nucleolus
GO:0035556
negative--- // GO:0005737
regulation// cytoplasm--// GO:0040008
of signal////GO:0005886
plasma○ transduction// GO:0045444
membrane// GO:0016020// protein////membrane
GO:0016567
ubiquitination// GO:0043// intrac/
NM_139311 Mllt6
myeloid/lymphoid
NM_139311
or mixed-lineage
RefSeq leukemia
Mus musculus(trithorax
FALSE
myeloid/lymphoidhomolog, Drosophila);
246198or mixed-lineage
Mm.23685
translocatedB1AR09
leukemia
to, 6(trithorax
chr11 homolog,
GO:0008150
Drosophila);
biological_processtranslocated
GO:0005575
to, 6 (Mllt6),
cellular_component
mRNA. GO:0046872metal// GO:0003674
ion binding○ //// GO:0008270
molecular_function // zinc ion bin
NM_001110778
Adam11a disintegrin NM_001110778
and metallopeptidase
RefSeq domain
Mus musculus
11
FALSE
a disintegrin and
11488
metallopeptidase
Mm.89854 domain
Q9R1V411 (Adam11),
chr11
transcript
GO:0006508
variantproteolysis//
1, GO:0007229
mRNA. //GO:0016020
integrin-mediatedmembrane// GO:0016021
signaling//GO:0004222
integralpathway
component
metalloendopeptidase// GO:0005515
of membrane○ // GO:0008237
activity // protein// GO:0008270
binding // me
NM_016780 Itgb3
integrin beta NM_016780
3
RefSeq
Mus musculus FALSE
integrin beta 3 16416(Itgb3), Mm.87150
mRNA.
O54890
chr11
GO:0001938positive// GO:0002687
regulation
GO:0005634//ofGO:0006457
endothelial
nucleus// GO:0005886
cell// plasma
GO:0006874
proliferation
GO:0003756//membrane
GO:0005925//protein//positive//GO:0007044
GO:0004872// disulfide
focal//
regulation
GO:0008305○
adhesion
isomerase////GO:0007155
of
GO:0005178
leukocyte// integrin// activity
GO:0009897
migration//complex//GO:0007160//GO:0005515
receptor//////GO:0009
proteinexternal
activity////GfoG
NM_015732 Axin2
axin2
NM_015732 RefSeq
Mus musculus FALSE
axin2 (Axin2), mRNA.
12006 Mm.71710 O88566
chr11
GO:0001756somitogenesis// GO:0001934
GO:0005622// positive// GO:0001957
intracellular
regulation// GO:0005634// of
GO:0003139
GO:0004871//protein
nucleus// GO:0005634
phosphorylation//signal//nucleus//GO:0003413
GO:0005096
transducer//// GO:0005737
cytoplasm○// intramembranous//activity//GO:0006355
GO:0005515// centrosome//// GO:0005813
GTPaseossification////GO:0007275
GO:0008013
activator// centrosome// GO:0005//activity
secon////GG
NM_198022 Tnrc6c
trinucleotide NM_198022
repeat containing
RefSeq
6C
Mus musculus FALSE
trinucleotide repeat
217351
containing
Mm.40272
6C (Tnrc6c),
Q3UHC0mRNA.
chr11
GO:0001706endoderm// GO:0006417
formation
GO:0005575// GO:0007492// regulation
cellular_componentof// translation
GO:0031047
GO:0000166// endoderm
nucleotide////GO:0035162
GO:0003676
development
binding○ ////GO:0048568//GO:0003723
nucleic// geneacid
silencing//binding//GO:0060213
GO:0003674
by// RNA
RNA//bin//Ge
NM_146016 Eml6
echinoderm microtubule
NM_146016associated
RefSeqproteinMus musculus
like 6
FALSE
echinoderm microtubule
237711 Mm.445271
associatedQ5SQM0
protein like 6
chr11(Eml6), mRNA.
GO:0008150biological_process
GO:0005737cytoplasm// GO:0005856//GO:0003674
cytoskeleton// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_010250 Gabra1
gamma-aminobutyric
NM_010250
acidRefSeq(GABA) A receptor,
Mus musculus
subunit
FALSE
gamma-aminobutyricalpha 1
14394 acid
Mm.439668(GABA) P62812
A receptor, subunit
chr11 alphaGO:0006810
1 (Gabra1), transportmRNA.
// GO:0006811// ion
GO:0005886
transport// GO:0006821
plasma////chloride
GO:0005887
membrane// transport
GO:0007165
GO:0004890// //GO:0016020//integral
signalGABA-A////GO:0007214
GO:0005216
transduction
component//
receptor
GO:0016021
○ of
////
activity//GO:0051932
plasma
GO:0005230
gamma-aminobutyric////membrane
GO:0030054
ion channel////GO:0034220
GO:0005254// activity
membrane//acid
GO:0034
signali//////ext
GG
NM_172524 Nipal4
NIPA-like domain
NM_172524
containing
RefSeq4
Mus musculus FALSE
NIPA-like domain
214112
containing
Mm.225253
4 (Nipal4),
Q8BZF2
mRNA.chr11
GO:0006810transport// GO:0006811// ion
GO:0016020
transport// GO:0015693
membrane////magnesium
GO:0016021// GO:0015693//GO:0015095
integralion//transport
GO:0005575
component
magnesium// GO:0003674// magnesiumof membraneion○ transmembrane
ion transport// cellular_component
transporter activity //NM_001029988
Fat2
FAT tumor suppressor
NM_001029988
homolog
RefSeq2 (Drosophila)
Mus musculus FALSE
FAT tumor suppressor
245827 Mm.339363
homolog 2 (Drosophila)
Q5F226(Fat2),
chr11 mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005634// homophilic// GO:0010631
nucleus//cell
GO:0005886
adhesion// plasma
GO:0007156
GO:0005509////membrane
epithelial
GO:0005913
calcium// GO:0007156
cell// migration
cell-cellion// GO:0016020
binding○ adherens////GO:0010631
homophilic//junction
GO:0016021
cell
// //
GO:0010631
adhesionmembrane// GO:0030// homo// in
NM_144825 Taok1
TAO kinase 1NM_144825 RefSeq
Mus musculus FALSETAO kinase 1216965(Taok1),Mm.340436
mRNA.
Q5F2E8chr11
GO:0000165MAPK// GO:0000186
cascadeGO:0005737////activation
GO:0006281
cytoplasm// of
GO:0070062
MAPKK// GO:0006468//GO:0000166
extracellular
activity// GO:0005737// nucleotide
DNA//vesicular//GO:0006915
GO:0004672
repair//exosomebinding
GO:0005737○// protein////GO:0006950//GO:0004674//protein
phosphorylation
cytoplasm
kinase//////GO:0006974
activitycytoplasm
GO:0004709// apoptotic// protein
//pro
//GG
NM_008702 Nlk
nemo like kinase
NM_008702 RefSeq
Mus musculus FALSE
nemo like kinase
18099(Nlk),Mm.9001
mRNA.
O54949chr11
GO:0000165MAPK// GO:0006351
cascadeGO:0005634////transcription,
GO:0006355
nucleus// GO:0005737
DNA-templated// cytoplasm
GO:0006468
GO:0000166// GO:0005634// //nucleus
nucleotide//regulation//GO:0007179
GO:0000287
bindingof○transcription,////GO:0016055//GO:0004672
magnesium
DNA-templated//ion//GO:0016310
GO:0004674
binding// protein// prote////GG
NM_013571 Ksr1
kinase suppressor
NM_013571
of ras 1RefSeq
Mus musculus FALSE
kinase suppressor
16706
of rasMm.4745
1 (Ksr1), mRNA.
Q61097chr11
GO:0006468protein// GO:0016310
phosphorylation
GO:0005737// GO:0035556//cytoplasm
phosphorylation// GO:0005783// GO:0043410//GO:0004672
endoplasmic//// GO:0016020
intracellular
protein
reticulum// GO:0004674
signalkinase// GO:0005789//○transduction
membrane
activity// GO:0005078// protein////endoplasmic
positiveserine/threonine// GO:0005515
regulation
reticulum
ofkinasMA//mG
NM_019505 Dgke
diacylglycerolNM_019505
kinase, epsilon
RefSeq
Mus musculus FALSE
diacylglycerol kinase,56077 epsilon
Mm.153695(Dgke),
Q9R1C6
mRNA. chr11
GO:0007205protein// GO:0008152
kinase
GO:0005737
C-activating// GO:0016310
cytoplasm//
G-protein
GO:0016020// GO:0035556//coupled
GO:0000166
membrane// GO:0016021
receptor
nucleotide////integral
GO:0003951
signaling//component
binding
GO:0005737○
pathway// //GO:0004143
NAD+of// membrane
metabolic// GO:0016020
kinase//activity
process
GO:0005524// cytoplasm////diacylgl
phosph//// mG
NM_001081045
Kansl1
KAT8 regulatory
NM_001081045
NSL complex
RefSeqsubunitMus
1 musculus FALSE
KAT8 regulatory
76719
NSL complex
Mm.136418
subunit
Q80TG11 (Kansl1),
chr11
mRNA. GO:0016568chromatin// GO:0043981
modification
GO:0000123// GO:0043982//histone
histone// GO:0005634
acetyltransferase
H4-K5// GO:0043984
GO:0043995
acetylation// GO:0071339
histonecomplex////GO:0043981//GO:0043996
histoneacetyltransferase//// GO:0000123
nucleusH4-K8○ ////GO:0043981
acetylation
GO:0046972// MLL1
activity// GO:0000123
complex//(H4-K5//histone//GO:0043982
GO:0043995// specific)
histoneH4-K16// GO:0005
acety
//ace
////GhG
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus FALSE
H3 histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244
chr11
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_011358 Srsf2
serine/arginine-rich
NM_011358
splicing
RefSeqfactor 2 Mus musculus FALSE
serine/arginine-rich
20382
splicing
Mm.21841
factor 2//Q62093(Srsf2),
Mm.469331
mRNA.
chr11
GO:0006397mRNA// GO:0008380
processing
GO:0005634// RNA
nucleus//splicing
GO:0005634// nucleus
GO:0000166// GO:0005681// spliceosomal
nucleotide// GO:0003676//complex
binding
GO:0016607○ // //GO:0003723//nucleic
nuclear// GO:0016607
acid
speck
binding// GO:0005515// nuclear////GO:0005
RNA
speck
bin
// G
NM_001099628
Atad2bATPase family,
NM_001099628
AAA domain
RefSeqcontainingMus
2Bmusculus FALSE
ATPase family,
320817AAA domain
Mm.210966
containing
E9Q1662B (Atad2b),
chr12 mRNA.GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleusprocess
GO:0000166nucleotide// GO:0005524
binding○ // //GO:0070577
ATP binding ////GO:0017111
lysine-acetylated// G
XM_006516065
Rgs6
regulator of G-protein
XM_006516065
signaling
RefSeq6
PREDICTED: Mus
FALSE
musculus regulator
50779 Mm.153013
of G-proteinQ9Z2H2
signaling 6 chr12(Rgs6), transcript
GO:0007165
variant signal
X2,// GO:0007186
mRNA.
transduction
GO:0005737// //GO:0009968
G-proteincytoplasm// GO:0005794
coupled// GO:0035556//GO:0004871
Golgi
receptor//apparatus
GO:0005834
signaling
signal////GO:0038032
GO:0005096//transducer
heterotrimericpathway// GO:0005886○ //activity//GO:0043547
GO:0005096
negative
G-protein//// GO:0016020
GTPaseregulation
complex////GO:0045666
GO:0005515
activator
of////signal
plasma
GO:0043
activity
trans
////m
GG
NM_028821 Dnal1
dynein, axonemal,
NM_028821
light chain
RefSeq1
Mus musculus FALSE
dynein, axonemal,
105000lightMm.101525
chain 1 (Dnal1),
Q05A62
mRNA.chr12
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
ENSMUST00000134311
Fos
FBJ osteosarcoma
ENSMUST00000134311
oncogene
ENSEMBL havana:putativeFALSE
chromosome:GRCm38:12:85474911:85476063:1
14281 Mm.246513 P01101// Mm.472279
chr12
gene:ENSMUSG00000021250
GO:0006355regulation// GO:0006355
gene_biotype:protein_codingof GO:0005634
transcription,// GO:0006366
nucleus
DNA-templated// GO:0005634// nucleus
GO:0007179
GO:0000979
transcript_biotype:processed_transcript// regulation
GO:0005634// nucleus
RNA////GO:0007399
GO:0003677
ofpolymerase// transcription,transcription// GO:0005667○ //II//GO:0031668
core
GO:0003677
factorDNA-templated
promoter// complex
GO:0005737//sequence-specific//GO:0034614
GO:0003690////cytoplasm
transcription// GO:0005//////GeDG
NM_177354 Vash1
vasohibin 1 NM_177354 RefSeq
Mus musculus FALSE
vasohibin 1 (Vash1),
238328mRNA.
Mm.216101 Q8C1W1 chr12
GO:0001525angiogenesis// GO:0001937
GO:0005576// negative// GO:0007049
extracellular
regulation// GO:0005615//of
GO:0007050
GO:0003674
regionendothelial// //GO:0005737
extracellularcellmolecular_function// GO:0009611
proliferation//
space
GO:0005783○ //// cell
cytoplasm
GO:0010596
cycle// GO:0045177// //cell
endoplasmic// cycle
GO:0010628
arrest// GO:0005
reticulum
// //
resp
G
NM_001025358
Klc1
kinesin light chain
NM_001025358
1
RefSeq
Mus musculus FALSE
kinesin light chain
16593
1 (Klc1),
Mm.278357
transcript
O88447variant b, chr12mRNA.
GO:0006886intracellular// GO:0007018
proteinGO:0005622// transport
GO:0008088
intracellular// GO:0005623// microtubule-based// GO:0035418
GO:0003777// cell// //GO:0005737
cytoplasm
microtubule//
movement//GO:0035617
GO:0005515// //cytosol
GO:0005829
motor○// axon////GO:0008152
activitycargo
GO:0015631
cytoskeleton//transport//GO:0005856
protein//////GO:0006886
kinesin//GO:0015631
binding
protein// complex
GO:0005//localizat
tubulin// G
NM_021361 Nova1
neuro-oncological
NM_021361
ventral RefSeq
antigen 1 Mus musculus FALSE
neuro-oncological
664883ventralMm.247195
antigen 1 Q9JKN6(Nova1), mRNA.
chr12
GO:0000398mRNA// GO:0000398
splicing,
GO:0005634
via// spliceosome
GO:0007399
nucleus// GO:0005634//// mRNA
nucleus
GO:0051252
GO:0003723
splicing,// GO:0005730// nucleolus
RNA
via// GO:0003729
spliceosome
binding// //intracellular
GO:0043231○// mRNA////GO:0005515
nervousmembrane-boundedbinding// GO:0005634
system// protein// GO:0044822
development
binding
organelle////pNM_001003719
Ralgapa1 Ral GTPase NM_001003719
activating protein,
RefSeqalpha subunit
Mus musculus
1
FALSE
Ral GTPase activating
56784 Mm.292180
protein, alphaQ6GYP7subunit 1 (Ralgapa1),
chr12transcript
GO:0006355
variant
regulation// GO:0032853
3, mRNA.
of GO:0005634
transcription,// GO:0032859
nucleus
DNA-templated// GO:0005737// cytoplasm
GO:0051056
GO:0005096// positive
GO:0005634// nucleus
GTPase////GO:0032859
regulation
GO:0005098//activator//cytoplasm
GO:0005737○
of Ran//activity//GO:0032859
GO:0005515
GTPase// mitochondrion//// GO:0005739
Ran
activity
GTPase// GO:0017123// activation
activatorof//acR
G
NM_177290 Itgb8
integrin beta NM_177290
8
RefSeq
Mus musculus FALSE
integrin beta 8320910(Itgb8), Mm.217000
mRNA.
Q0VBD0chr12
GO:0001573ganglioside// GO:0007155
metabolic
GO:0016020// GO:0007229
process
membrane// GO:0016021// cell// GO:0007160//
adhesion
GO:0005102
integral// GO:0070062
component// integrin-mediatedreceptor////GO:0007275
GO:0004872
ofbinding// membrane
GO:0008305○ signaling////receptor
GO:0005102// extracellularpathway
activity // vesicular
receptorcell-matrix
bindinexosomadh
NM_001039188
Rreb1
ras responsive
NM_001039188
element binding
RefSeqproteinMus
1 musculus FALSE
ras responsive 68750
elementMm.491109
binding protein
Q3UH061 (Rreb1),
chr13
transcript variant
GO:0006351
2, mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// GO:0005737// regulation// cytoplasm
GO:0003676
of// GO:0070062
transcription,// extracellular
nucleic// GO:0003677
acid
DNA-templated// GO:0005634
vesicular○binding// GO:0003700//exosomeDNA//// negative
GO:0016607
binding// nucleus// regulation
GO:0046872// sequence-spe// nuclearof trans
NM_153789 Mylip
myosin regulatory
NM_153789
light chain
RefSeqinteractingMus
proteinmusculus FALSE
myosin regulatory
218203lightMm.212855
chain interacting
Q8BM54protein chr13(Mylip), mRNA.
GO:0006928cellular// GO:0007399
component
GO:0005622// movement
GO:0010989
intracellular// GO:0005737// nervous// GO:0016567
GO:0004842// cytoplasm
system// GO:0005856
development
ubiquitin-protein//////GO:0016567
cytoskeleton
GO:0004842// GO:0005886○// negativetransferase////GO:0031648
plasma
GO:0008092
regulation//membrane
GO:0016020
activity////of
GO:0032803
GO:0008270//low-density
ubiquitin-protei// membrane// GO:0019
lipop////GG/
NM_001081425
Rbm24
RNA bindingNM_001081425
motif proteinRefSeq
24
Mus musculus FALSE
RNA binding motif
666794proteinMm.38269
24 (Rbm24),
D3Z4I3
mRNA. chr13
GO:0010830regulation// GO:0030154
of GO:0005634
myotube// GO:0043488
differentiation
nucleus// GO:0005737// cytoplasm//GO:0000166
cell differentiation// GO:0005575// cellular_component
nucleotide// GO:0003676// regulation
binding○ // //
of
GO:0003723
nucleic
mRNA acidstability
binding// GO:0003730// RNA bin
AK029314 Tes3-ps
testis derivedAK029314
transcript 3,GenBank
pseudogene
HTC
Mus musculus FALSE
0 day neonate head
54339cDNA,
Mm.441473
RIKEN Q9QZ73
full-length enriched
chr13 library,---clone:4832420G24--product:testis
GO:0000151
derivedubiquitintranscript
ligase--- complex
3, pseudogene,--full insert○ sequence.
NM_172589 Lhfpl2
lipoma HMGIC
NM_172589
fusion partner-like
RefSeq 2 Mus musculus FALSE
lipoma HMGIC
218454
fusion partner-like
Mm.3165532Q8BGA2(Lhfpl2), mRNA.
chr13
GO:0008150biological_process
GO:0016020membrane// GO:0016021// integral// GO:0005575
componentmof membrane○// cellular_componen
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17352884
17353581
17353781
17354906
17355512
1735811917358363
17358905
17360501
17360845
17360873
17363704
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17372161
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17398863
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17401023
17401749
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17424215
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17426497
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17431075
17431272
17433359
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17435008
17435584
17437674
17438134
17438272
17438602

70.27698
41.28774
46.49517
49.68916
67.68957
644.2003
31.07785
23.64622
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63.57816
2029.166
150.6622
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240.5276
159.97151.903230.30587
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19.73595
36.137494.2603
326.9945
120.6395
113.9983
488.2575

81.52174
34.01439
45.82178
54.36963
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24.24413
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180.0614
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0.1491308

0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main
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NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr18
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_178005 Lrrtm2
leucine rich repeat
NM_178005
transmembrane
RefSeq neuronal
Mus musculus
2
leucine
TRUE rich repeat
107065transmembrane
Mm.39900 Q8BGA3
neuronal 2 (Lrrtm2),
chr18 mRNA.
GO:0002091negative// GO:0050808
regulation
GO:0005886//of
GO:0050808
receptor
plasma// GO:0016020
internalization
membrane// GO:0060291
GO:0042043// //GO:0016021// membrane
synapseneurexin////GO:0050808
GO:0042043
organization//
family// integral
GO:0030054○ proteincomponent// synapse
binding// GO:0045202
organization
of// membrane
neurexin//family
GO:0045// //long-ter
cell
prot
ju
ENSMUST00000097612
Gm10545 predicted gene
ENSMUST00000097612
10545 ENSEMBL ensembl:knownTRUE
chromosome:GRCm38:18:37008869:37020679:-1--Mm.474985 Q3UTM7 chr18gene:ENSMUSG00000073594
GO:0008150biological_process
gene_biotype:protein_coding
GO:0005575cellular_component
GO:0003674
transcript_biotype:protein_coding
molecular_function○
NM_001039485
Piezo2
piezo-type mechanosensitive
NM_001039485
RefSeqion channel
Muscomponent
musculus piezo-typeTRUE
2mechanosensitive
667742 Mm.158720
ion channel
Q8CD54component
chr18 2 (Piezo2),
GO:0006810
mRNA. transport// GO:0006811// ion
GO:0005886
transport// GO:0006812
plasma////cation
GO:0016020
membrane//transport
GO:0006812
GO:0005261// ////
GO:0016021
cationmembranecation////GO:0034220
transport
GO:0008381
channel// integral○// ionactivity////transmembrane
GO:0042391
component
GO:0008381// mechanically-gatedof //membranetransport
GO:0009612//
ionregulachan// G
NM_001164504
Rnf165ring finger protein
NM_001164504
165 RefSeq
Mus musculus ring
TRUE
finger protein
225743165 Mm.23293(Rnf165), mRNA.
E9QAU8chr18
GO:0000209protein// GO:0007409
polyubiquitination
GO:0005634// GO:0008045
nucleus////axonogenesis
GO:0043234// protein
GO:0010259
GO:0004842//complex
motorubiquitin-protein//neuron//GO:0030163
GO:0005515
axon○guidance
transferase////GO:0030513
GO:0008270// multicellular
activity////GO:0035136
GO:0046872// proteinorganismal
binding//ag
G
NM_009551 Zfand5
zinc finger, AN1-type
NM_009551
domainRefSeq5
Mus musculus zinc
TRUE
finger, AN1-type
22682 domain
Mm.292405
5 (Zfand5),
O88878mRNA.
chr19
GO:0001701in//utero
GO:0001944
embryonic
GO:0005737//development
GO:0003016
cytoplasm////vasculature
GO:0010761
GO:0003677
development
DNA////GO:0048008
GO:0008270
binding//○
respiratory// zinc////GO:0048705
GO:0046872
ion systembinding process// metal
GO:0048745//
ionfibroblastbinding// Gm
NM_177360 Dmrt3
doublesex and
NM_177360
mab-3 related
RefSeqtranscription
Mus factor
musculus
3 doublesex
TRUE
and240590
mab-3 related
Mm.62785transcription
Q80WT2
factorchr19
3 (Dmrt3), mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005634// regulation// nucleus
GO:0007548
GO:0003677
of transcription,
DNA////GO:0007628
GO:0003700
binding
DNA-templated○// sequence-specific////GO:0019226
GO:0043565// multicellular////DNA
GO:0021521
GO:0046872
organismal
binding trans
////G
de
G
NM_001163471
Hectd2
HECT domain
NM_001163471
containingRefSeq
2
Mus musculus HECTTRUE domain226098
containing
Mm.61107
2 (Hectd2),
Q8CDU6transcript chr19
variant 1, mRNA.
GO:0042787protein// GO:0016567
ubiquitination
GO:0005634// GO:0042787
involved
nucleus// GO:0005737
in ubiquitin-dependent// cytoplasm
GO:0004842// GO:0005634// nucleus
ubiquitin-protein//protein
GO:0008766////catabolic
cytoplasm
GO:0005737○ transferase// process
GO:0016874
activity// protein// GO:0018169// ubiquitination
UDP-N-acetylm// G/
NM_001142918
Tcf7l2transcription NM_001142918
factor 7 like 2,
RefSeqT cell specific,
Mus musculus
HMG box transcription
TRUE
factor21416
7 likeMm.139815
2, T cell specific,
Q924A0HMGchr19
box (Tcf7l2),GO:0000122
transcript variant
negative// GO:0000122
1, mRNA.
regulation
GO:0000790//ofGO:0001568
transcription
nuclear// GO:0005634
chromatin//from
GO:0005977
GO:0000978
RNA////GO:0005634
polymerase
nucleusRNA////GO:0006006
GO:0000978//polymerase
nucleusII //promoter
GO:0005654○ ////II//nucleoplasm
GO:0006351//
core
GO:0001103
negative
promoter// GO:0005667
regulation////proximaltranscription//GO:0006355
GO:0003677
of//regiontranscripti
GO:0005
factor//seq//GG
NM_010132 Emx2
empty spiracles
NM_010132
homeobox
RefSeq2
Mus musculus empty
TRUE spiracles13797
homeobox
Mm.245394
2 (Emx2),
Q04744
mRNA. chr19
GO:0006355regulation// GO:0007275
of GO:0005634
transcription,// GO:0007420
nucleus
DNA-templated// GO:0009952
GO:0000976// multicellulartranscription////GO:0009952
GO:0003677
organismal○
regulatory////GO:0010468
development
GO:0003700
region sequence-specific////GO:0021542
brain
GO:0043565
developmen
DNA// G
NM_178421 Nanos1
nanos homolog
NM_178421
1 (Drosophila)
RefSeq
Mus musculus nanos
TRUE homolog
332397
1 (Drosophila)
Mm.186390(Nanos1),
Q80WY3
mRNA.chr19
GO:0006417regulation// GO:0010631
of GO:0005737
translation// GO:0016477//cytoplasm
epithelial// GO:0048471// cell
GO:0010631//GO:0003723
perinuclear
migration// GO:0005737
RNA
region// //cell
GO:0010631
GO:0008270
binding
migrationof //cytoplasm
GO:0005737○// zinc////GO:0016477
epithelial
GO:0046872
ion// cytoplasm
binding// GO:0048471
cell migration////metal
GO:0016477
cytoplasm
GO:0003674
ion////GO:0048
bindingepithelia// //per//GG
NM_001166414
Rfx3
regulatory factor
NM_001166414
X, 3 (influences
RefSeq HLA Mus
classmusculus
II expression)
regulatory
TRUE
factor19726
X, 3 (influences
Mm.313321
HLA
P48381class II expression)
chr19(Rfx3),
GO:0006351
transcripttranscription,//variant
GO:0006355
2, mRNA.
GO:0000790
DNA-templated// GO:0007275
nuclear// GO:0000790// regulation
chromatin// GO:0007368
GO:0003677
of////GO:0005634
transcription,
nuclearDNA////GO:0030154
GO:0003700
chromatin
binding
DNA-templated// GO:0005667○////sequence-specific//nucleus//GO:0031018
GO:0005515//////multicellular
GO:0000790
transcription////DNA
GO:0042384
GO:0044212
organismal
bindingfactor comp
trans
////G
de
G
NM_172471 Itih5inter-alpha (globulin)
NM_172471
inhibitor
RefSeqH5
Mus musculus inter-alphaTRUE(globulin)
209378inhibitor
Mm.313876
H5 (Itih5),
Q8BJD1
mRNA.chr2
GO:0010466negative// GO:0030212
regulation
GO:0005576//of
GO:0008150
peptidase
extracellular// GO:0005575
activity// GO:0010951
GO:0004867
region// hyaluronan// cellular_component
serine-type// GO:0030414
metabolicendopeptidase○process// GO:0003674// biological_process
inhibitor activity ////peptidas
negativ
NM_011923 Angptl2
angiopoietin-like
NM_011923
2
RefSeq
Mus musculus angiopoietin-like
TRUE
26360
2 (Angptl2),
Mm.208919
mRNA.
Q9R045chr2----GO:0005576extracellular// GO:0070062--region // extracellular--vesicular○exosomeENSMUST00000124210
A430018G15Rik
RIKEN cDNAENSMUST00000124210
A430018G15ENSEMBLgene
havana:known chromosome:GRCm38:2:52425012:52431893:1
TRUE----Q8R0S4
chr2
gene:ENSMUSG00000085315----gene_biotype:processed_transcript------- transcript_biotype:processed_transcript--○
NM_053263 Hnrnpa3
heterogeneous
NM_053263
nuclear ribonucleoprotein
RefSeqMusA3
musculus heterogeneous
TRUE
229279nuclearMm.316306
ribonucleoprotein
Q8BG05// Mm.331491
A3 (Hnrnpa3),
chr2// Mm.379375
transcript
GO:0006397
variant mRNAc,//mRNA.
GO:0008380
processing
GO:0005634// //GO:0051028
RNA
nucleus//splicing
GO:0005681// //spliceosomal
GO:0055085
GO:0000166
mRNA// GO:0005737
transport
complex
nucleotide// GO:0003676// transmembrane// binding
cytoplasm
GO:0019012○ // //GO:0003723
nucleic//transportvirion// GO:0019013
acid// viralbinding// GO:0003729
nucleocapsid////GO:0030
RNA bin// /G
NM_172666 Agps
alkylglycerone
NM_172666
phosphateRefSeq
synthase Mus musculus alkylglycerone
TRUE
228061
phosphate
Mm.31227
synthase Q8C0I1(Agps), mRNA.
chr2
GO:0006629lipid// GO:0008610
metabolic
GO:0005730
process// GO:0055114//nucleolus
lipid// GO:0005739
biosynthetic// //GO:0008610
GO:0003824
mitochondrion//processGO:0005739
catalytic//////GO:0008611//GO:0008609
oxidation-reduction
mitochondrion
activity// GO:0005777○ //////GO:0008611
alkylglycerone-phosphate
GO:0008762// peroxisome
process// GO:0005778// //lipid//GO:0016491
peroxisomal
biosynthetic// GO:0043
synthaseme//pG
ENSMUST00000028398
Ube2e3ubiquitin-conjugating
ENSMUST00000028398
enzymeENSEMBLE2E 3 ensembl_havana_transcript:known
TRUE
22193chromosome:GRCm38:2:78869047:78921293:1
Mm.1485 // P52483
Mm.396925 chr2// Mm.426742
GO:0040008
gene:ENSMUSG00000027011
regulation// GO:0070534
of GO:0005634
growth// GO:0070936// protein
nucleus//gene_biotype:protein_coding
GO:0005737
K63-linked// cytoplasm
GO:0070979
GO:0000166
ubiquitination// GO:0005634// nucleus
nucleotide////GO:0070534
GO:0004842//transcript_biotype:protein_coding
proteinbinding○ K48-linked////GO:0070936//GO:0005515
ubiquitin-protein
ubiquitination////GO:0070979
GO:0005524
transferase// protein//acti//K1
GG
NM_011393 Slc1a2
solute carrierNM_011393
family 1 (glial
RefSeqhigh affinityMus
glutamatemusculustransporter),soluteTRUE carrier
memberfamily20511
21 (glial
Mm.267547
high affinity
P43006glutamatechr2
transporter),
GO:0006810
member 2transport(Slc1a2),// GO:0006835//transcript
dicarboxylic
GO:0005886// GO:0007399
variant
acid
plasma//3,GO:0005887
transportmRNA.
membrane// GO:0007632
GO:0005313// nervous// //GO:0016020
integralsystemL-glutamate////GO:0009416
GO:0005313
component
development// GO:0016021○
transmembraneof////GO:0009611
plasma
GO:0005314// visual// membrane
GO:0030424
transporter
behavior////GO:0010259
GO:0015293////activity
membrane
response// GO:0030////L-g//to
GG
NM_009754 Bcl2l11
BCL2-like 11NM_009754(apoptosis facilitator)
RefSeq
Mus musculus BCL2-likeTRUE
11 (apoptosis
12125 Mm.141083
facilitator) (Bcl2l11),
O54918 transcript
chr2 variant
GO:0001701
3, mRNA. in//utero
GO:0001776
embryonic
GO:0005622//development
GO:0001776
intracellular// GO:0005737////leukocyte
GO:0001782
GO:0005515// cytoplasm// GO:0005739
homeostasis
protein//////GO:0001782
mitochondrion
GO:0008017
binding//// leukocyte
GO:0005739○ //////
microtubule//
GO:0001783
GO:0008017
mitochondrion
homeostasis// GO:0005739
binding// //GO:0001822//Bmitochondrioncell// microtubule//homeostas
GO:0005// G
NM_001291056
Snap25synaptosomal-associated
NM_001291056
RefSeqprotein 25 Mus musculus synaptosomal-associatedTRUE
20614 Mm.45953
protein 25P60879(Snap25), transcript
chr2
variant
GO:0007269
2, mRNA.
neurotransmitter// GO:0007616
GO:0005623
secretion// GO:0010975
cell//// GO:0005737
long-term// cytoplasm// GO:0016197
GO:0000149
memory// GO:0005737
cytoplasm//SNARE//regulation//GO:0030431
GO:0000149// binding
endosome// of
GO:0005768○neuron//////GO:0034765
SNARE
GO:0005249//projection
trans-Golgi// GO:0005802
bindingdevelopment//network//GO:0046887
GO:0005515// voltage-gated////GO:0005
cytosol// endos////GpG
NM_019806 Vapb
vesicle-associatedNM_019806
membrane
RefSeqprotein,Mus
associatedmusculus
proteinvesicle-associated
TRUE
B and C 56491
membrane
Mm.260456
protein,
Q9QY76
associatedchr2
protein B and
GO:0006874
C (Vapb),cellularmRNA.
// GO:0006986
calcium
GO:0005783
ion// homeostasis
GO:0006987
endoplasmic// GO:0005789////response
GO:0019048
GO:0005198
reticulum// GO:0005794
to unfolded//structural//endoplasmic//GO:0030968
GO:0019899
protein//molecule
GO:0016020○reticulum// //activation//GO:0045070
activity
GO:0042803
membrane// of
GO:0016021// signaling
enzyme////GO:0006874//GO:0046982
Golgi
binding
protein// GO:0005
apparatus
activity// prote////GG
NM_001290376
Camk1dcalcium/calmodulin-dependent
NM_001290376
RefSeqproteinMus
kinasemusculusID
calcium/calmodulin-dependent
TRUE
227541 Mm.191949
protein
Q8BW96kinase IDchr2(Camk1d), transcript
GO:0006468
variant
protein// GO:0006954
4, mRNA.
phosphorylation
GO:0005634// GO:0007399//nucleus
inflammatory// GO:0005737// cytoplasm
GO:0008152
GO:0000166
response// GO:0005634// nucleus
nucleotide//////nervous
GO:0010976
GO:0003824////nucleus
systembinding
GO:0005634○ ////development
GO:0016310//GO:0004672
catalytic
cytoplasm// GO:0005737
activity//////
metaboliccytoplasm
GO:0032793
GO:0004674// protein// GO:0005
processkinas////GG
NM_001290576
Pbx3
pre B cell leukemia
NM_001290576
homeobox
RefSeq3
Mus musculus pre
TRUE
B cell leukemia
18516
homeobox
Mm.239941
3 (Pbx3),
O35317transcript
chr2
variant b, GO:0002087
mRNA.
regulation// GO:0006351
of GO:0005634
respiratory// GO:0006355
gaseousnucleus// GO:0005667
exchange// transcription
GO:0007585
GO:0003677
by// GO:0005634
neurologicalfactorDNA////GO:0008344
GO:0003700
complexbindingsystem○////sequence-specificprocess
nucleus////GO:0021516
GO:0005515// transcription,////DNA
GO:0048666
GO:0043565
binding
DNA-templa
trans
// G
NM_001100591
Rc3h2
ring finger and
NM_001100591
CCCH-type
RefSeqzinc finger Mus
domains
musculus
2
ring
TRUE
finger and319817
CCCH-type
Mm.288785
zinc finger
P0C090domains 2chr2(Rc3h2), transcript
GO:0000209
variant
protein//1,
GO:0001782
mRNA.
polyubiquitination
GO:0005634// GO:0009791
nucleus////BGO:0005737
cell //homeostasis
cytoplasm
GO:0010468
GO:0003677// GO:0009986//// cell
post-embryonic
DNA////GO:0010608
surface
GO:0003723
binding// GO:0016020//○membrane// development
RNA////GO:0035264
GO:0003729
binding//// GO:0000932
cytoplasmic// regulation
mRNA////GO:0042098
GO:0004842
bindingmRNA//ofGO:0005
gene
proce
////ubiexp//GG
ENSMUST00000028087
Ppp6c
protein phosphatase
ENSMUST00000028087
6, catalytic
ENSEMBL
subunitensembl_havana_transcript:known
TRUE
67857chromosome:GRCm38:2:39194354:39226451:-1
Mm.389242 Q9CQR6// Mm.171389
chr2// Mm.392662
GO:0006470// Mm.398121
gene:ENSMUSG00000026753
protein// GO:0007049
dephosphorylation// Mm.475023
GO:0005737// GO:0006470
cytoplasm// gene_biotype:protein_coding
GO:0005829
cell cycle// GO:0006470//GO:0004721
cytosol// protein// GO:0005829// cytosol
dephosphorylation
phosphoprotein// GO:0004722//transcript_biotype:protein_coding
cytosol// GO:0005829○ phosphatase// GO:0016787
protein dephosphorylation
activity// GO:0046872// protein serine/// G
NM_001289521
Zeb2
zinc finger E-box
NM_001289521
binding RefSeq
homeobox 2 Mus musculus zinc
TRUE
finger E-box
24136
binding
Mm.440702
homeoboxQ9R0G7
2 (Zeb2), transcript
chr2
variant
GO:0001755
3, mRNA.neural// GO:0001756
crest cell
GO:0005634
migration// GO:0001843
nucleus// GO:0005634
somitogenesis// nucleus
GO:0006351
GO:0003676// //GO:0005730//neuralnucleolus
nucleic////GO:0006355
tube
GO:0003677
acid//closure//cytoplasm
GO:0005737○
binding// //transcription,
GO:0007417
GO:0003700// DNA binding
DNA-templated////GO:0021766
GO:0043565// sequence-spe//////reg
GG
NM_001037099
Cacnb4
calcium channel,
NM_001037099
voltage-dependent,
RefSeqbeta
Mus 4musculus
subunit calcium
TRUE channel,
12298
voltage-dependent,
Mm.330223 Q8R0S4
beta 4 subunit
chr2 (Cacnb4),
GO:0006810
transcript transportvariant// GO:0006811
1, mRNA.
// ion
GO:0005886
transport// GO:0006816
plasma////calcium
GO:0005891
membrane// ion
GO:0006816
GO:0005244
transport// //GO:0005891
voltage-gated//voltage-gated////calcium
GO:0006874
GO:0005245//ion
calcium
GO:0005891○transport
ion//channel//GO:0007214
channel
GO:0005245// //cellular
activity
GO:0045202
complex//calcium//GO:0007528
GO:0005262
voltage-gated// voltage-gated//ion
GO:0005
homeos//cal//GG
NM_001001182
Baz2b
bromodomain
NM_001001182
adjacent toRefSeq
zinc finger domain,
Mus musculus
2B
bromodomain
TRUE
407823
adjacentMm.228071
to zinc finger
A0PJF0domain, 2Bchr2(Baz2b), mRNA.
GO:0008150biological_process
GO:0005575cellular_component// GO:0005634
GO:0046872// nucleus
metal// GO:0003674
ion binding○ //// GO:0003677
molecular_function// GO:0008270// DNA bindin
NM_001025093
Atf2
activating transcription
NM_001025093
factor
RefSeq2
Mus musculus activating
TRUE
transcription
11909 Mm.209903
factor 2 (Atf2),
P16951transcript chr2
variant 1, mRNA.
GO:0003151outflow// GO:0006351
tract GO:0005634
morphogenesis// GO:0006355
nucleus// GO:0005634// transcription,// nucleus
GO:0006366
GO:0000980// DNA-templated
GO:0005737// cytoplasm
RNA////GO:0006970
GO:0001077
polymerase////mitochondrion
GO:0005739//○
regulation//II//GO:0006974
distal
GO:0001102
ofenhancer////transcription,
GO:0005741
mitochondrial////GO:0016573
sequence-specific
GO:0003676
DNA-template//outer
GO:0016memb////GG
NM_001111289
Caprin1cell cycle associated
NM_001111289
protein
RefSeq1
Mus musculus cell
TRUE
cycle associated53872protein
Mm.427589
1 (Caprin1),
Q60865transcript
chr2variant 2,GO:0017148
mRNA.
negative// GO:0030154
regulation
GO:0000932//of
GO:0050775
translation
cytoplasmic// GO:0005737////cell
GO:0061003
mRNA
GO:0003723
differentiation// processing
GO:0010494
RNA////GO:0017148
GO:0044822// binding
positive
body// GO:0010494○// regulation//cytoplasm
poly(A)////GO:0017148
GO:0003723
RNAof////dendrite
GO:0042995
cytoplasmic
binding//morphogenesis
GO:0003723// RNA
stress// GO:0000
binding
granul//NM_001145824
Hipk3
homeodomain
NM_001145824
interactingRefSeq
protein kinaseMus
3 musculus homeodomain
TRUE
15259
interacting
Mm.257925
protein kinase
Q9ERH73 (Hipk3),
chr2transcriptGO:0000122
variant 2, mRNA.
negative// GO:0006351
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0005634//fromnucleus
GO:0006468
GO:0000166
RNA// GO:0005737//
polymerase
cytoplasm
nucleotide////GO:0006468
GO:0003677
II////
promotercytoplasm
binding
GO:0005737○ ////GO:0006915//GO:0003714
DNA
transcription,// PML//binding
GO:0016605
body////DNA-templated
GO:0009299//GO:0004672
nucleustranscription// GO:0005// cytop
//cor
//G
//G
NM_138313 Bmf
BCL2 modifying
NM_138313
factor RefSeq
Mus musculus BCL2
TRUEmodifying
171543factor Mm.210125(Bmf), mRNA.
Q91ZE9chr2
GO:0006915apoptotic// GO:0032464
process
GO:0001669////GO:0043276
positive
acrosomal// GO:0005737
regulation// vesicle
GO:0090200
GO:0005515
of protein////GO:0015629
cytoplasm
homooligomerization
protein// GO:2001234//
binding//actin
GO:0016459○ cytoskeleton// GO:2001235// anoikis// GO:0016459// myosin// //positive
GO:0043276
complexregulation// GO:0001// //myGoNM_001081133
Kif16bkinesin familyNM_001081133
member 16B
RefSeq
Mus musculus kinesin
TRUE family member
16558 Mm.251934
16B (Kif16b),
B1AVY7
mRNA. chr2
GO:0001704formation// GO:0001919
of primary
GO:0005622// GO:0006810
germintracellular
layer// GO:0005623// //regulation
GO:0006895
GO:0000166// cell// //of
GO:0005737
cytoplasm
receptor
nucleotide////GO:0007018
GO:0003777
recycling// //endosome
binding
GO:0005768○ //////
transport
GO:0007173//GO:0005524
microtubule// early// GO:0005769//endosome
Golgi//motor//GO:0007492
to
GO:0005547
endosome
activity////cytoskeleto
GO:0005////tran
AT//GG
NM_177586 Eif5a2
eukaryotic translation
NM_177586
initiation
RefSeqfactor 5A2
Mus musculus eukaryotic
TRUE
translation
208691 initiation
Mm.193670
factorQ8BGY25A2 (Eif5a2),
chr3
mRNA. GO:0006412translation// GO:0006414//GO:0005634
translational// GO:0006452
nucleuselongation// GO:0005643// nuclear
GO:0006810
GO:0003723// translational//pore
GO:0005737//RNA//cytoplasm//frameshifting
GO:0008284
GO:0003746
binding// GO:0005783○////endoplasmictranslation//////transport
GO:0008612
GO:0043022// elongation
GO:0016020
reticulum// positive// GO:0015031
factorregulation// membrane// GO:0005
activity
of
// ce
G//
NM_027016 Sec62
SEC62 homolog
NM_027016(S. cerevisiae)
RefSeq
Mus musculus SEC62
TRUE homolog
69276(S. cerevisiae)
Mm.26017(Sec62),
Q8BU14mRNA.
chr3
GO:0006620posttranslational// GO:0006810
GO:0005622
protein// GO:0015031
targetingintracellular// GO:0005623
to// membrane
GO:0006620
GO:0008565// cell// //GO:0005783
endoplasmic// proteintransport////GO:0006620
GO:0003674
transporter//reticulum//GO:0016020
protein○activitytransport// membrane// //GO:0016021
molecular_function// posttranslational// integral// GO:0005
componeprote
NM_001098170
Pcdh10
protocadherinNM_001098170
10
RefSeq
Mus musculus protocadherin
TRUE
10
18526
(Pcdh10),
Mm.242644
transcript
E9PX28variant 1, chr3mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007155
plasma//cell
GO:0005887
adhesionmembrane// GO:0007156
GO:0005509////cell//
GO:0016020
integraladhesion
calcium// GO:0005515
component//ion//homophilic
GO:0016021
binding○ of plasma//cellproteinadhesionmembranebinding // membrane
NM_177855 Med12l
mediator complex
NM_177855
subunitRefSeq
12-like
Mus musculus mediator
TRUE complex
329650subunitMm.240059
12-like (Med12l),
Q8BQM9mRNA.
chr3
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0006357
nucleus// GO:0016592// regulation// mediator
GO:0006366
GO:0001104
of transcription,complex
RNA////GO:0008150
GO:0008013
polymerase
DNA-templated○ II// transcription
GO:0008134// regulation
cofactorof transcription
activity // be
NM_178892 Tiparp
TCDD-inducible
NM_178892
poly(ADP-ribose)
RefSeq polymerase
Mus musculus TCDD-inducible
TRUE
99929
poly(ADP-ribose)
Mm.246398polymerase
Q8C1B2 (Tiparp),
chr3
mRNA.
GO:0001570vasculogenesis// GO:0001822
GO:0005634// //kidney
GO:0006471
nucleusdevelopment// GO:0005634// nucleus
GO:0006807
GO:0003950// protein ADP-ribosylation
NAD+////GO:0008209
GO:0003950
ADP-ribosyltransferase○ ////GO:0008210
nitrogen
GO:0016740
compoundactivity////GO:0008585
GO:0016757//metabolic
NAD+ ADP-r
proc////GGENSMUST00000119109
Etv3
ets variant 3 ENSMUST00000119109
ENSEMBL havana:known chromosome:GRCm38:3:87525407:87540156:1
TRUE
27049 Mm.219460 Q8R4Z4// Mm.446456
chr3
gene:ENSMUSG00000003382// Mm.457227
GO:0000122negative// GO:0006351
gene_biotype:protein_coding
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0017053//fromtranscriptional
GO:0006357
transcript_biotype:protein_coding
GO:0000981
RNA polymerase
sequence-specific//repressor//GO:0006366
GO:0003677
II promoter
complex○ ////DNA
GO:0030154//GO:0003700
transcription,binding RNA////DNA-templated
GO:0006366
GO:0005515
polymerase //
II//G
tra
//G
NM_008231 Hdgf
hepatoma-derived
NM_008231
growthRefSeq
factorMus musculus hepatoma-derived
TRUE
15191
growthMm.292208
factor (Hdgf),
P51859mRNA. chr3
GO:0000122negative// GO:0006351
regulation
GO:0005615//of
GO:0006355
transcription
extracellular// GO:0005615//from
GO:0006366
GO:0000166
space
RNA
// //GO:0005634
polymerase
extracellular
nucleotide////GO:0009987
GO:0001106
II space//
promoterbinding
GO:0005634○ //////nucleus
GO:0034504//GO:0001222
RNAtranscription,//polymerase//
GO:0005737
nucleus////DNA-templated
GO:0045944
GO:0003677//II cytoplasm
transcription// GO:0017
////G
//G
NM_001029890
Mex3a
mex3 homolog
NM_001029890
A (C. elegans)
RefSeq
Mus musculus mex3
TRUEhomolog 72640
A (C. elegans)Mm.275154(Mex3a),G3UYU0mRNA. chr3
GO:0008150biological_process
GO:0005575cellular_component
GO:0044822poly(A)// GO:0046872
RNA○binding// GO:0003723// metal ion binding// GO:0008270// RNA bind
NM_001165948
Pogz
pogo transposable
NM_001165948
element
RefSeqwith ZNF domain
Mus musculus pogo
TRUEtransposable
229584element
Mm.274787
with ZNF
Q8BZH4domain (Pogz),
chr3 transcript
GO:0007049
variant 2, cellmRNA.
// GO:0007064
cycle // GO:0000790
mitotic// sister
GO:0051301
nuclearchromatid// GO:0005634
chromatin// GO:0051382
cohesion
GO:0003676////GO:0005694
nucleus// cell
nucleic////GO:0007064
division
GO:0003677// chromosome
acid// GO:0005737//○
binding
kinetochore////GO:0007064
GO:0046872//// DNA
cytoplasm
assembly// GO:0000790
binding// //GO:0051382//nuclear//mitotic
metal// GO:0000
chromation
sisterbind// Gch
NM_001037737
Arntaryl hydrocarbon
NM_001037737
receptorRefSeq
nuclear translocator
Mus musculus aryl
TRUEhydrocarbon
11863
receptor
Mm.250265
nuclear translocator
P53762 (Arnt),
chr3 transcript
GO:0001666
variant 1, response
mRNA.
// GO:0001666
to hypoxia
GO:0005634// GO:0001892// response
nucleus// GO:0005634
to//hypoxia
nucleus
GO:0006351
GO:0000989////GO:0005667//embryonictranscription
transcription////GO:0006355
GO:0003677
placenta//factor
GO:0005667○
factordevelopment
complex////GO:0007165
binding
GO:0003700////transcription
GO:0005737
transcription// transcription,////GO:0009636
GO:0003705
factorfactor// GO:0005
DNA-teactivity
compl////GG
NM_207205 Igsf3
immunoglobulin
NM_207205
superfamily,
RefSeqmemberMus
3 musculus immunoglobulin
TRUE
78908
superfamily,
Mm.489667
memberQ6ZQA63 (Igsf3), chr3mRNA.
GO:0032808lacrimal gland
GO:0016020
development
membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_181400 Wdr47
WD repeat domain
NM_181400
47 RefSeq
Mus musculus WD
TRUE
repeat domain
99512
47 Mm.285968(Wdr47), mRNA.
Q8CGF6chr3
GO:0007275multicellular// GO:0008150
GO:0005737
organismal development
cytoplasm// GO:0005856//GO:0003674//cytoskeleton
biological_process// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_020265 Dkk2
dickkopf homolog
NM_020265
2 (Xenopus
RefSeqlaevis) Mus musculus dickkopf
TRUE homolog
56811
2 (Xenopus
Mm.103593
laevis)Q9QYZ8(Dkk2), mRNA.
chr3
GO:0007275multicellular// GO:0016055
GO:0005576
organismal// GO:0030178
development
extracellular// GO:0005615// GO:0090090--region// Wnt// //GO:0005576
signaling
extracellular--// GO:0090263
pathway//
space
GO:0005615○// negative// extracellular
GO:0090090
regulation
region// GO:0090263
of Wnt// extracellularsignaling p
NM_019745 Pdcd10
programmedNM_019745
cell death 10RefSeq
Mus musculus programmed
TRUE
cell
56426
deathMm.316473
10 (Pdcd10),
Q8VE70mRNA. chr3
GO:0001525angiogenesis// GO:0006915
GO:0005737// apoptotic// GO:0008284
cytoplasm
process// GO:0005794////GO:0043066//positive
GO:0042803
Golgi//apparatus
GO:0005829
regulation
protein////GO:0043406
GO:0047485//
of cytosol
homodimerizationcell// GO:0005886
proliferation○ ////plasma//GO:0008284
GO:0005515////
membrane
activity
negative
GO:0016020//////GO:0008284
regulation
proteinGO:0042803// membrane// N-terminu
GO:0070of apop////G//G
NM_001162999
Fnip2
folliculin interacting
NM_001162999
protein
RefSeq2
Mus musculus folliculin
TRUE interacting
329679proteinMm.244005
2 (Fnip2),
Q80TD3
mRNA. chr3
GO:0000122negative// GO:0001932
regulation
GO:0005622//of
GO:0006468
transcription
intracellular// GO:0005634//from
GO:0006974
GO:0003674// nucleus
RNA// GO:0005737
polymerase//molecular_function//cytoplasm
GO:0008630
II //promoter
GO:0005737//○cytoplasm// GO:0033138// regulation// GO:0005815
microtubuleof//protein
GO:0000122
organizing
phosphoryla// GO:0005// ce
G
NM_173347 Prune
prune homolog
NM_173347(Drosophila)
RefSeq
Mus musculus prune
TRUEhomolog
229589(Drosophila)
Mm.14155(Prune),Q8BIW1
mRNA. chr3
GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleus// GO:0005737
process// cytoplasm
GO:0004427// GO:0030054// cellinorganic// junction
GO:0016462//diphosphatase
GO:0005737○// cytoplasm// GO:0016787
activity//// GO:0005925
focal //adhesion//pyrophosphatase
GO:0030145 // aG
NM_010432 Hipk1
homeodomain
NM_010432
interactingRefSeq
protein kinaseMus
1 musculus homeodomain
TRUE
15257
interacting
Mm.20827
protein kinase
O889041 (Hipk1),
chr3mRNA. GO:0000122negative// GO:0006351
regulation
GO:0005622//of
GO:0006355
transcription
intracellular// GO:0005634//from
GO:0006468
GO:0000166// nucleus
RNA// GO:0005634
polymerase//nucleotide//nucleus//GO:0007224
GO:0003677
II //promoter//binding
GO:0005737
cytoplasm○ ////GO:0008284//GO:0003714
DNA
transcription,// cytoplasm//binding
GO:0005737////DNA-templated
GO:0009952//GO:0004672//transcription
PML// GO:0016
body ////cor//G//nG
NM_010306 Gnai3
guanine nucleotide
NM_010306
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
314679
binding
Mm.271703
protein (GQ9DC51protein), alphachr3 inhibiting
GO:0006184
3 (Gnai3),GTP
mRNA.
// GO:0006906
catabolic
GO:0005737
process// GO:0007049//cytoplasm
vesicle// GO:0005737
fusion// GO:0007165//GO:0000166
cytoplasm// cell// GO:0005765
cycle//
nucleotide////
lysosomal
GO:0007186//GO:0003924
signal// binding
GO:0005794
transduction○
membrane////GO:0007188//GO:0003924
GTPase//////Golgi
G-protein
GO:0005813
activity
apparatus////GO:0007193
GO:0004871
coupled// GTPase// //GO:0005
receptor
centroso
activ////GG
NM_019550 Ptbp2
polypyrimidine
NM_019550
tract binding
RefSeqprotein 2 Mus musculus polypyrimidine
TRUE
56195
tract binding
Mm.29966
proteinQ91Z31
2 (Ptbp2), mRNA.
chr3
GO:0006376mRNA// GO:0006376
spliceGO:0005634
site selection// GO:0006397
nucleus////GO:0005681
mRNA// spliceosomal
GO:0008380
splice
GO:0000166
site selection
complex
nucleotide////GO:0033119
GO:0003676// mRNAbinding○ //processing//GO:2000177//GO:0003723
nucleic acid// RNA//binding//GO:0033119
GO:0003729
splicing// RNA// negatbin// G
NM_019586 Ube2j1
ubiquitin-conjugating
NM_019586
enzymeRefSeq
E2J 1 Mus musculus ubiquitin-conjugating
TRUE
56228 enzyme
Mm.259095
E2J 1Q9JJZ4(Ube2j1), mRNA.
chr4
GO:0016567protein// GO:0018279
ubiquitination
GO:0005783// GO:0030433// protein
endoplasmic// GO:0016020
N-linked// GO:0016567
GO:0000166
reticulum
glycosylation// GO:0016021//nucleotide//membrane//GO:0018279
via
GO:0004842
asparagine// binding
GO:0005575○// integral////GO:0018279//GO:0005524
ER-associatedubiquitin-protein
component// GO:0005789////of
GO:0030433
GO:0016874
ubiquitin-depende
membranetransferase////acti//ce
GG
XM_006537592
Cnr1
cannabinoid XM_006537592
receptor 1 (brain)
RefSeq
PREDICTED: Mus
TRUE
musculus cannabinoid
12801 Mm.7992
receptorP47746
1 (brain) (Cnr1),
chr4 transcript
GO:0002866
variant X2,positivemRNA.
// GO:0007165
regulation
GO:0005886//ofGO:0007186
acuteplasma//inflammatory
GO:0016020
membrane// GO:0007188
GO:0004871
response// //GO:0016021
membranesignalto////GO:0007568
antigenic
GO:0004930
transducer//// integral
GO:0043231
stimulus○ //activity//GO:0007611
component
GO:0004949// signal//// GO:0030424
G-proteintransductionof //membrane//GO:0007613
GO:0008144
coupled// GO:0030////G-prote
receptointrace////GG
NM_178756 E130309F12Rik
RIKEN cDNANM_178756
E130309F12
RefSeqgene
Mus musculus RIKENTRUE cDNA272031
E130309F12
Mm.299460
gene (E130309F12Rik),
Q8BFZ2chr4 mRNA. GO:0007399nervous// GO:0007399
system
GO:0016020
development// GO:0008152
membrane// GO:0016021// nervous//GO:0003824
integralsystem// GO:0005575
component
development
catalytic ofactivity
membrane○// metabolic// process
cellular_component
NM_139309 Fktn
fukutin
NM_139309 RefSeq
Mus musculus fukutin
TRUE (Fktn),246179
mRNA. Mm.247210 Q8R507
chr4
GO:0001764neuron// GO:0008285
migration
GO:0005634// GO:0046329
negativenucleus// GO:0005783
regulation// endoplasmic
GO:0060049
GO:0016740
of cell// GO:0005794
proliferation
reticulumtransferase////GO:0008152
GO:0043842//////negative
GO:0005794
activity
Golgi○ //apparatus
GO:0008285
regulation// Kdo//transferase
GO:0005801//ofGolgi
JNK// GO:0008285
apparatus
cascadeactivity// GO:0016////regu//cisGENSMUST00000107415
Zfp618zinc finger protein
ENSMUST00000107415
618 ENSEMBL ensembl_havana_transcript:known
TRUE
72701chromosome:GRCm38:4:62965573:63139708:1
Mm.26479 //Q80YY7
Mm.482416chr4
GO:0006351
gene:ENSMUSG00000028358
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleusgene_biotype:protein_coding// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
transcript_biotype:protein_coding
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr4
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_172698 Efcab14
EF-hand calcium
NM_172698
bindingRefSeq
domain 14 Mus musculus EF-hand
TRUE calcium
230648binding
Mm.283565
domain 14
Q8BGQ6(Efcab14), chr4mRNA.
GO:0008150biological_process
GO:0005575cellular_component
GO:0046872metal// GO:0003674
ion binding○ //// GO:0005509
molecular_function // calcium ion
ENSMUST00000106283
Rims3
regulating synaptic
ENSMUST00000106283
membrane
ENSEMBL
exocytosis
havana:known
3
chromosome:GRCm38:4:120861777:120896579:1
TRUE
242662 Mm.192502 Q80U57// Mm.388896
chr4//gene:ENSMUSG00000032890
Mm.396765
GO:0006810// Mm.479706
transport// GO:0006836////
gene_biotype:protein_coding
Mm.489236
neurotransmitter
GO:0005623// GO:0006887
cell// GO:0030054
transport// cell// junction
GO:0017156
GO:0044325//transcript_biotype:protein_coding
exocytosis// //GO:0045202
synapseion////GO:0042391//channel
GO:0005515
calciumbinding○
ion-dependent// GO:2000300// protein
exocytosis
binding// GO:2000300// regulation o
NM_018774 Phc2
polyhomeotic-like
NM_018774
2 (Drosophila)
RefSeq
Mus musculus polyhomeotic-like
TRUE
54383
2 (Drosophila)
Mm.490300(Phc2),Q9QWH1transcript
chr4
variant 1, GO:0007275
mRNA.
multicellular// GO:0007283
GO:0000792
organismal development
heterochromatin// GO:0005634
GO:0003677// spermatogenesis//// nucleus
GO:0005634
DNA// //GO:0005515
nucleusbinding// GO:0031519○//// protein
PcG// GO:0008270
proteinbinding// GO:0031519
complex// zinc// GO:0046872//
ionPcG//binding
GO:0035
protein//
ENSMUST00000084241
Wasf2
WAS proteinENSMUST00000084241
family, member
ENSEMBL2
ensembl_havana_transcript:known
TRUE
242687chromosome:GRCm38:4:133130505:133199756:1
Mm.23566 //Q8BH43
Mm.416453chr4
GO:0001525
gene:ENSMUSG00000028868
angiogenesis// GO:0001667
GO:0001726// ameboidal// GO:0006897
ruffle//cell
GO:0005622
gene_biotype:protein_coding
migration// intracellular// GO:0006928
GO:0003779////endocytosis
GO:0005622// intracellular
actin////GO:0010592
GO:0005515
binding// cellular//transcript_biotype:protein_coding//GO:0005737○
cytoplasm// protein
component////GO:0016601
GO:0032403
binding// //early
GO:0005769
movement
endosome////protein//GO:0030032
GO:0005515// complex//positive//GO:0005
cytoskel
//reg
bin
G
ENSMUST00000105868
Stmn1
stathmin 1 ENSMUST00000105868
ENSEMBL havana:known chromosome:GRCm38:4:134469742:134473499:1
TRUE
16765 Mm.378957 P54227
chr4gene:ENSMUSG00000028832
GO:0007019microtubule// GO:0007052
gene_biotype:protein_coding
depolymerization
GO:0005622// GO:0007275
intracellular// GO:0005737// mitotic// GO:0007399
GO:0005515// transcript_biotype:protein_coding
cytoplasm
spindle// GO:0005829
organization
protein//////GO:0007409
cytosol
GO:0015631
binding// //GO:0005856//○
multicellularcytoskeleton//////
tubulinGO:0030154
GO:0015631
binding
organismal// //GO:0005874
microtubule////GO:0031110
tubulindevelopment////binding
GO:0016
membran// //G
NM_177733 E2f2
E2F transcription
NM_177733
factor 2RefSeq
Mus musculus E2F
TRUE
transcription
242705factorMm.307932
2 (E2f2), mRNA.
P56931
chr4
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007049
nucleus// GO:0005667// regulation// transcription
GO:0051726
GO:0001047
of// GO:0005634
transcription,
factorcore////GO:0072332
GO:0003677
promotercomplex
DNA-templated○binding// nucleus////GO:1990086
GO:0003700// DNA// cellbinding
cycle////GO:0006355
GO:0005515// //regulation
sequence-sp
of
// G
c
NR_030771 Gm13034 SWI/SNF related,
NR_030771
matrix RefSeq
associated, actin
Mus musculus
dependentpredicted
TRUE
regulator geneof chromatin,
62758513034 (Gm13034),
Mm.424988
subfamily a,B2RT32
non-coding
member 5RNA.
chr4
pseudogene --------GO:0003677DNA// GO:0005524
binding○// ATP binding
NM_001159344
Casz1
castor zinc finger
NM_001159344
1
RefSeq
Mus musculus castor
TRUE zinc finger
69743
1 (Casz1),
Mm.233879
transcript
Q9CWL2variant 1,chr4mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005737// regulation// cytoplasm
GO:0008150
GO:0003677
of// GO:0043231
transcription,// intracellular
DNA// GO:0046872
binding
DNA-templated// GO:0005634
membrane-bounded○// metal ion////binding
multicellular
GO:0005737
organelleorganismal////GO:0043
nucleusde
NM_145711 Tox
thymocyte selection-associated
NM_145711 RefSeqhigh mobility
Mus musculus
group box
thymocyte
TRUE
selection-associated252838 Mm.435828
highQ66JW3
mobility groupchr4box (Tox),---mRNA. --GO:0005634nucleus
GO:0003677DNA binding○
NM_001177849
Asphaspartate-beta-hydroxylase
NM_001177849
RefSeq
Mus musculus aspartate-beta-hydroxylase
TRUE
65973 Mm.222206(Asph), Q8BSY0transcript variant
chr4 3, mRNA.
GO:0007389pattern// GO:0008285
specification
GO:0005737// GO:0010524
process
cytoplasm// GO:0005783// negative// GO:0018193//GO:0004597
endoplasmic
regulation// GO:0005886
peptide-aspartate//ofreticulum//GO:0031585
cell
GO:0005509
proliferation// GO:0016020//○plasma//beta-dioxygenase//GO:0031647
GO:0005515// positive
membrane// GO:0016021
regulation////GO:0032237
activity
membrane
GO:0016491
of//calcium
GO:0030// calcium////inte//G
ioG
NM_026893 Dcaf12
DDB1 and CUL4
NM_026893
associated
RefSeqfactor 12 Mus musculus DDB1
TRUE and CUL4
68970
associatedMm.28891
factor 12
Q8BGZ3(Dcaf12), chr4mRNA.
GO:0008150biological_process// GO:0016567
GO:0005737// protein
cytoplasm// GO:0005813
ubiquitination//GO:0003674
centrosome// GO:0005856
molecular_function// cytoskeleton// GO:0080008○ // Cul4-RING// GO:0005737
E3 ubiquitin// ligase
GO:0005
com
ENSMUST00000157313
Gm26049 predicted gene,
ENSMUST00000157313
26049 ENSEMBL ncrna:known chromosome:GRCm38:4:41312091:41312198:-1
TRUE----Q8BGZ3
chr4
gene:ENSMUSG00000087938----gene_biotype:snRNA----- transcript_biotype:snRNA----○
NM_172381 AI314180 expressed sequence
NM_172381
AI314180
RefSeq
Mus musculus expressed
TRUE
sequence
230249AI314180
Mm.234801(AI314180),
Q6PDI5 mRNA.
chr4
GO:0030433ER-associated
GO:0000502
ubiquitin-dependent
proteasome// GO:0005634
proteincomplex--- catabolic// GO:0005737// nucleus---process////cytoplasm
GO:0005768○// endosome// GO:0005769// early//endosome
GO:0005
NM_144904 Ptbp3
polypyrimidine
NM_144904
tract binding
RefSeqprotein 3 Mus musculus polypyrimidine
TRUE
230257
tract binding
Mm.331640
proteinQ8BHD73 (Ptbp3), transcript
chr4
variant
GO:0006397
1, mRNA.mRNA// GO:0008380
processing
GO:0005634// //GO:0030154
RNAnucleussplicing// //GO:0033119
GO:0000166
cell differentiation
nucleotide////GO:0043249
GO:0003676// negative
binding○ //regulation//GO:0045595//GO:0003723
nucleicofacidRNA//binding//GO:0033119
splicing
GO:0044822// RNA// erythro//binG
NM_172694 Megf9
multiple EGF-like-domains
NM_172694 RefSeq
9
Mus musculus multiple
TRUE EGF-like-domains
230316 Mm.251188
9 (Megf9),
Q8BH27
mRNA. chr4----GO:0016020membrane// GO:0016021//---integral component--of membrane○
ENSMUST00000106061
S100pbp
S100P binding
ENSMUST00000106061
protein ENSEMBL ensembl_havana_transcript:known
TRUE
74648chromosome:GRCm38:4:129148005:129189542:-1
Mm.172064 Q9D5K4// Mm.408391
chr4// Mm.488265
GO:0008150gene:ENSMUSG00000040928
biological_process
GO:0005634nucleus// GO:0005634
gene_biotype:protein_coding// nucleus
GO:0048306calcium-dependent// GO:0048306
transcript_biotype:protein_coding○
protein binding // calcium-depend
NM_175306 Phactr4
phosphataseNM_175306
and actin regulator
RefSeq4
Mus musculus phosphatase
TRUE
and100169actinMm.158361
regulator 4 (Phactr4),
Q501J7 transcript
chr4 variant
GO:0001755
1, mRNA. neural// GO:0001843
crest cell
GO:0005622
migration// GO:0007266
intracellular// GO:0005737
neural// tube
GO:0007275
GO:0003779// cytoplasm
closure// GO:0030027//actin//Rho////GO:0007399
lamellipodium
GO:0004864
binding
protein// GO:0042995○
signal// protein//////GO:0030036
transduction
GO:0008157
cellphosphataseprojection// GO:0030027////GO:0043085
multicellular//GO:0071862
inhibitor
lamellipodium
activity
organ////GG
NM_001080819
Arid1aAT rich interactive
NM_001080819
domainRefSeq
1A (SWI-like)Mus musculus AT
TRUE
rich interactive
93760
domainMm.22478
1A (SWI-like)A2BH40(Arid1a),chr4
mRNA. GO:0000122negative// GO:0001843
regulation
GO:0000790//ofGO:0003205
transcription
nuclear// GO:0000790
chromatin//from
GO:0003408
GO:0003677
RNA////GO:0005622
polymerase
nuclearDNA////GO:0006325
GO:0005515
chromatin
bindingII //promoter
GO:0005634○////protein//intracellular//GO:0006337//GO:0016922
neuralbinding// GO:0016514
tube
// //
nucleus//closureligand-dependent//GO:0006338
GO:0031491//// SWI/SNF
cardiac
GO:0016////G
chnG
NM_001163794
Pdik1lPDLIM1 interacting
NM_001163794
kinaseRefSeq
1 likeMus musculus PDLIM1
TRUE interacting
230809kinaseMm.22778
1 like (Pdik1l),
Q8QZR7transcript
chr4variant 2,GO:0006468
mRNA.
protein// GO:0016310
phosphorylation
GO:0005634//nucleus
phosphorylation// GO:0005575// cellular_component
GO:0000166nucleotide// GO:0004672
binding○ // //GO:0004674
protein kinase// activity
GO:0005524// protein// G
NM_001081557
Camta1
calmodulin binding
NM_001081557
transcription
RefSeqactivator
Mus1musculus calmodulin
TRUE
binding
100072transcription
Mm.318846
activator
A2A8911 (Camta1),
chr4 transcript
GO:0006351
variant 1,transcription,mRNA.
// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// GO:0005737// regulation// cytoplasm
GO:0003677
of transcription,
DNA// GO:0003674
binding
DNA-templated○// molecular_function// biological_process
NM_001099299
Ajap1
adherens junction
NM_001099299
associated
RefSeqprotein 1Mus musculus adherens
TRUE
junction
230959associatedMm.318874
proteinA2ALI51 (Ajap1), mRNA.
chr4
GO:0007155cell// GO:0008150
adhesionGO:0005886// biological_process
plasma// GO:0016020
membrane
GO:0003674// //GO:0016021
membranemolecular_function//// integral
GO:0030054○
component// GO:0005575
of membrane// GO:0005// cell ju
NM_001170745
Magi2
membrane associated
NM_001170745
guanylate
RefSeq kinase,MusWWmusculus
and PDZ
membraneTRUEdomain containing
associated50791 2Mm.332231
guanylate kinase,
Q9WVQ1WW andchr5
PDZ domain
GO:0002092
containing
positive//
2 GO:0007165(Magi2),
regulation
GO:0005634
transcript//ofGO:0007399
receptorvariant
nucleus// GO:0005737
internalization
3, mRNA.
// cytoplasm
GO:0008285
GO:0004871// //GO:0005737
signal// cytoplasm
signal////GO:0010976
transduction
GO:0005515
transducer// //GO:0005768○
endosome//activity//nervous
GO:0016482
GO:0019902//////latesystem
GO:0005770
proteinendosome////development
GO:0030336
binding
GO:0030159//// GO:0005//plasma
phosph//////neGm
G
NM_153526 Insig1
insulin induced
NM_153526
gene 1 RefSeq
Mus musculus insulin
TRUE induced
231070gene 1Mm.30221(Insig1), mRNA.
Q8BGI3chr5
GO:0006629lipid// GO:0006641
metabolic
GO:0005783
process// GO:0006695//endoplasmic
triglyceride// GO:0005783// GO:0006991
GO:0005515
metabolicreticulum// GO:0016020
process//protein//endoplasmic
GO:0008202//bindingcholesterol// GO:0016021○reticulum// GO:0008203
biosynthetic////membrane
GO:0032937
process// GO:0010894// integral// response
GO:0005
com// G
NM_008453 Klf3
Kruppel-like factor
NM_008453
3 (basic)
RefSeq
Mus musculus Kruppel-likeTRUEfactor16599
3 (basic)
Mm.439720(Klf3), mRNA.
Q60980chr5
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:1901653
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// cellularbinding//response
GO:0003677// metalto
ion
peptidbind
NM_001190734
Dcun1d4
DCN1, defective
NM_001190734
in cullin RefSeq
neddylation 1,
Musdomainmusculus
containing
DCN1,
TRUE4 defective(S. cerevisiae)
100737in cullin
Mm.220312
neddylation
Q8CCA01, domain chr5
containing 4GO:0008150(S. cerevisiae)
biological_process(Dcun1d4),
GO:0005634
transcript variant
nucleus// GO:0005575
A,//mRNA.
cellular_component
GO:0003674molecular_function○
NM_001122733
Kit
kit oncogeneNM_001122733
RefSeq
Mus musculus kit
TRUEoncogene (Kit),
16590
transcript
Mm.247073
variantP05532
1, mRNA. chr5
GO:0000187activation// GO:0001541
of MAPK
GO:0001669// activity
GO:0002318
acrosomal////GO:0005615
ovarian// vesicle
GO:0002320
GO:0000166
follicle////development
GO:0005622
extracellular
nucleotide////GO:0002327
GO:0002020
space////myeloid
binding
GO:0005737○ ////intracellular//GO:0002371
progenitor//GO:0004672
protease// GO:0005886
cell//bindingcytoplasm//differentiation//GO:0002551
GO:0004713// protein// GO:0005// plasma//kinas//lym//GG
NM_177680 Ythdc1
YTH domain conta
M
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17519967
17520815
17522848
17523081
17526130
17528714
17529713
17530930
17530955
17531734
17533416
17535208
17535241
17538018
17538395
17538658
17539828
17541343
17543840
17544102
17544939
17545078
17545618
17545629
17546834
17547616
17547837
17547846
17548283
17548518
17548946

66.36326
372.401
200.9076
63.08196
363.0498
257.718385.1018
60.10501
1003.845
32.55711
688.9457
861.1144
113.162
18.69999
10.53644
22.98368
29.0719528.04365
12.0706
56.45731
299.5348
88.37831
47.19572
11.86074642.2186
821.7177
96.34195
101.3808
1129.61
1145.085
993.8382

77.80013
381.8084
205.7395
70.94463
339.0828
235.3805
331.4807
64.3563986.2798
28.70505
512.7594
1145.401
124.9131
16.33215
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24.19338
24.83115
21.40386
12.03887
56.45731
360.417195.12606
57.85563
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541.8898
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92.70303
948.6991
1182.456
826.8755

0.8529968
0.9753609
0.9765145
0.8891717
1.0706819
1.0948995
1.1617624
0.9339414
1.0178096
1.1341945
1.3436042
0.7518017
0.9059258
1.1449803
1.0732467
0.9499987
1.1707855
1.3102146
1.0026356
10.8310782
0.9290652
0.8157498
0.8919801
1.1851461
1.068423
1.1251055
1.0936083
1.1906937
0.9683954
1.20192-0.229388-0.035992-0.034287-0.169466
0.0985299
0.1307985
0.216315-0.098596
0.0254676
0.1816681
0.4261082-0.411576-0.142535
0.1953228
0.1019818-0.074003
0.2274768
0.3898031
0.0037974
0-0.266944-0.106148-0.293801-0.164917
0.245065
0.0954829
0.1700603
0.1290961
0.2518023-0.046332
0.2653409

0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 mainNM_011627 Tpbg
trophoblast glycoprotein
NM_011627 RefSeq
Mus musculus trophoblast
TRUE
glycoprotein
21983 Mm.20864(Tpbg), transcript
Q9Z0L0variant
chr9
1, mRNA. ----GO:0005737cytoplasm// GO:0005783//--endoplasmic// GO:0016020---reticulum// GO:0016021//○membrane ////GO:0005886
integral component of me
NM_001100451
Msl2
male-specificNM_001100451
lethal 2 homolog
RefSeq(Drosophila)
Mus musculus male-specificTRUE
lethal77853
2 homolog
Mm.326206(Drosophila)
Q69ZF8// Mm.436586(Msl2),
chr9mRNA. GO:0043984histone// GO:0043984
H4-K16
GO:0072487
acetylation
MSL////GO:0072487
histonecomplex
GO:0008270
H4-K16// MSL// GO:0072487
acetylation
complexzinc// GO:0008766
ion// binding
MSL○complex////UDP-N-acetylmuramoylalanyl-D-gl
GO:0016874 // GO:0018169 // G
NM_001048146
Azi2
5-azacytidineNM_001048146
induced gene
RefSeq2
Mus musculus 5-azacytidine
TRUE
induced27215 gene
Mm.92705
2 (Azi2),
Q9QYP6transcript variant
chr9 2, mRNA.
GO:0000278mitotic// GO:0001816
cell cycle
GO:0005737// cytokine
GO:0007249
cytoplasm// production
GO:0005737// GO:0032607//GO:0005515
cytoplasm// I-kappaB// GO:0005739//
protein// mitochondrion
kinase/NF-kappaB
GO:0032609
binding// GO:0005886○ //// GO:0032635
plasmasignaling
membrane// interferon-alpha// GO:0032640 prod// G
NM_007397 Acvr2b
activin receptor
NM_007397
IIB
RefSeq
Mus musculus activin
TRUE receptor11481
IIB (Acvr2b),
Mm.390239
mRNA.
P27040chr9
GO:0001501skeletal// GO:0001501
system
GO:0005623
development// GO:0001702
cell// GO:0005737//// cytoplasm
skeletal// GO:0001822
GO:0000166
system// GO:0005886
plasmadevelopment
nucleotide////GO:0001822
membrane
GO:0004672// binding
GO:0016020//○gastrulation// //membrane//GO:0001946//GO:0004674
protein//with
GO:0016021
kinase// mouth
integral////GO:0001974
activity
GO:0004674
formingcomponent// GO:0043// second
protein////of
GG
NM_007619 Cbl
Casitas B-lineage
NM_007619
lymphoma
RefSeq
Mus musculus Casitas
TRUE B-lineage12402
lymphoma
Mm.266871(Cbl), P22682
mRNA.
chr9
GO:0007166cell// GO:0014068
surface receptor
GO:0005634// GO:0023051
signaling
nucleus// GO:0005737
pathway// cytoplasm
GO:0043066
GO:0001784// positive// GO:0005886// plasma
regulation
phosphotyrosine////GO:0006468
GO:0004842
membrane//ofGO:0016020○
phosphatidylinositol//
binding//GO:0014068//GO:0004871
membrane// ubiquitin-protein
GO:0016600
3-kinase//////GO:0016567
flotillin
GO:0005509//
signaling
complex
GO:0005transferas////G//G
NM_001253862
Tcf12
transcription NM_001253862
factor 12
RefSeq
Mus musculus transcription
TRUE
factor21406
12 (Tcf12),
Mm.171615
transcript
Q61286variant chr9
2, mRNA. GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005667// regulation// transcription
GO:0007399
GO:0003677
of// GO:0005634
transcription,
factorDNA////GO:0010628
GO:0003700
complexbinding
DNA-templated○////sequence-specificnucleus////GO:0030154
GO:0005515// multicellular////DNA
GO:0045666
GO:0035497
organismal
binding trans
////G
de
G
NM_001114977
U2surpU2 snRNP-associated
NM_001114977
SURP
RefSeqdomain Mus
containing
musculus U2
TRUE
snRNP-associated67958 Mm.292742
SURP domain
Q6NV83containingchr9(U2surp), transcript
GO:0006396
variant
RNA// 1,
GO:0008150
processing
mRNA.GO:0005634// biological_process
nucleus// GO:0005634// nucleus
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0044822// RNA bin
NM_001042779
Sema3bsema domain,
NM_001042779
immunoglobulin
RefSeqdomainMus(Ig),musculus
short basic
sema
TRUE
domain,domain,secreted,
20347
immunoglobulin(semaphorin)
Mm.4083domain
Q62177
3B (Ig), shortchr9
basic domain,
GO:0007275
secreted,multicellular(semaphorin)// GO:0007399
GO:0005576
organismal
3B//(Sema3b),
GO:0030154
development
extracellular// GO:0016020
transcript
GO:0004872
region// variant
nervous// membrane
1,systemmRNA.
receptordevelopment
activity○// cell differentiation
NM_008138 Gnai2
guanine nucleotide
NM_008138
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
214678
binding
Mm.196464
protein (GP08752protein), alphachr9 inhibiting
GO:0000186
2 (Gnai2),activationmRNA.
// GO:0001973
of MAPKK
GO:0005634// GO:0006184
activity
nucleus// GO:0005737// adenosine// cytoplasm
GO:0007049
GO:0000166
receptor// GO:0005813// centrosome
nucleotide//signaling//GO:0007165
GO:0001664//pathwaybinding
GO:0005829○// cytosol////GO:0007186////
GO:0003924
G-protein
GTP// heterotrimeric// catabolic
GO:0005834
coupled////GO:0007188
GO:0004871
process
G-proteinreceptor// GO:0005// cellbindcom////GcG
NM_016853 Stacsrc homologyNM_016853
three (SH3)RefSeq
and cysteineMusrichmusculus
domain src
TRUEhomology three
20840
(SH3)
Mm.1414and cysteine
P97306rich domainchr9(Stac), mRNA.
GO:0034605cellular// GO:0035556
response
GO:0005737
to heat cytoplasm////intracellular
GO:0005575//GO:0046872
cellular_component
signal transduction
metal// GO:0003674
ion binding○// molecular_function
NM_010028 Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His)
NM_010028 RefSeqbox polypeptide
Mus musculus
3, X-linked
DEAD/HTRUE (Asp-Glu-Ala-Asp/His)
13205 Mm.289662
boxQ62167
polypeptidechrX3, X-linked (Ddx3x),
GO:0002376
mRNA.
immune// GO:0006200
system
GO:0005634
process// GO:0006351
nucleus////ATPGO:0005737
catabolic// cytoplasm
GO:0006355
GO:0000166
process// GO:0005739// mitochondrion
nucleotide//////GO:0006417
transcription,
GO:0003676// binding
GO:0005741○ // //
DNA-templated
mitochondrial//GO:0006915//GO:0003677
nucleic// GO:0005852
acid
outer
////binding//GO:0007059
regulation
GO:0003723
membrane////GO:0010
DNAof trans////bin//eu
GG
NM_001290424
Fmr1
fragile X mental
NM_001290424
retardation
RefSeqsyndrome Mus
1 musculus fragile
TRUE X mental14265
retardation
Mm.3451
syndrome
P35922
1 (Fmr1), chrXtranscript variant
GO:0006810
2, mRNA.
transport// GO:0007417// central
GO:0005634// nervous
GO:0045947
nucleus//system
GO:0005737// development
cytoplasm
GO:0051028
GO:0003723// GO:0005844// polysome//RNAnegative// GO:0005515
binding////regulation
GO:0005845
mRNA○// protein// cap
GO:0008017
of translationalbindingbinding// GO:0005874
complex// microtubule// initiation
GO:0044822// microtubu
GO:0010//bindingmRNA// G
ENSMUST00000096420
Styx
serine/threonine/tyrosine
ENSMUST00000096420
interaction
ENSEMBLprotein
havana:known chromosome:GRCm38:X:68821093:68825318:1
TRUE
56291 Mm.202561 Q60969// Mm.434636
chrX
gene:ENSMUSG00000071748
GO:0006470protein// GO:0007283
dephosphorylation
gene_biotype:protein_coding
GO:0005737// GO:0016311
cytoplasm// GO:0005634
spermatogenesis// GO:0045204//transcript_biotype:protein_coding
GO:0004721
nucleus // dephosphorylation
phosphoprotein////GO:0070372
GO:0005515○ phosphatase//// GO:0008138
MAPK export
activityfrom// GO:0016787// nucleus
protein bindin// reg// G
NM_013724 Nrk
Nik related kinase
NM_013724 RefSeq
Mus musculus Nik
TRUE
related kinase
27206(Nrk),
Mm.482319
mRNA. Q9R0G8
chrX
GO:0006468protein// GO:0007256
phosphorylation
GO:0005737// GO:0007567//cytoplasm
activation// GO:0005737// GO:0008285
of//GO:0000166
cytoplasm
JNKK activity
nucleotide////GO:0016310//
GO:0004672
parturition
binding○ ////GO:0023014
negative//GO:0004672
proteinregulation
kinase////GO:0035556
activity
GO:0004674
of cell //proliferat
protein////GG
NM_001033795
Zcchc16
zinc finger, CCHC
NM_001033795
domainRefSeq
containing Mus
16 musculus zinc
TRUE
finger, CCHC
619287
domainMm.387961
containing
Q3URY016 (Zcchc16),
chrX mRNA. GO:0008150biological_process
GO:0005575cellular_component
GO:0003676nucleic// GO:0008270
acid ○
binding// GO:0046872// zinc ion binding// GO:0003674// metal ion b
NM_001271678
Wnk3
WNK lysine deficient
NM_001271678
protein
RefSeqkinase 3 Mus musculus WNK
TRUElysine deficient
279561 protein
Mm.441474
kinaseQ80XP93 (Wnk3), transcript
chrX
variant
GO:0006468
1, mRNA.
protein// GO:0010765
phosphorylation
GO:0005737// GO:0010800//cytoplasm
positive// GO:0005912//regulation
GO:0016310//GO:0000166
adherens// of
GO:0005923
sodiumjunction
nucleotide////GO:0032414
GO:0004672
ion// transport//
tightbinding
GO:0005737○junction////GO:0043066////GO:0004674
positive
protein// cytoplasm
kinaseregulation////GO:0046777
activity
GO:0005524
of peptidyl-thr// protein////GG
NM_019461 Usp27x
ubiquitin specific
NM_019461
peptidase
RefSeq27, X chromosome
Mus musculus ubiquitin
TRUE specific54651
peptidase
Mm.483107
27, X chromosome
Q8CEG8// Mm.491689(Usp27x),
chrX
mRNA.
GO:0006508proteolysis// GO:0006511//GO:0005575
ubiquitin-dependent
cellular_component
proteinGO:0008233
catabolicpeptidase
process// GO:0008234
activity○ //// GO:0016787
cysteine-type peptidase// GO:0036459
activity// G/
NM_001290708
Smarca1
SWI/SNF related,
NM_001290708
matrix RefSeq
associated, actin
Mus musculus
dependentSWI/SNF
TRUE
regulator of
related,chromatin,
93761
matrixMm.229151
subfamily
associated,
a,Q6PGB8
memberactin dependent
1 chrX regulator
GO:0000733
of chromatin,
DNA// GO:0006200
subfamily
strand renaturation
GO:0000790
a, member// GO:0006338
nuclear//1//ATP(Smarca1),
GO:0005634
catabolicchromatin// GO:0006351
GO:0000166
transcript
process////GO:0016589
nucleusvariant
nucleotide//////GO:0006355
chromatin
GO:0003676
// 2,
NURF
//mRNA.
binding
GO:0090537○remodelingcomplex////GO:0007420//GO:0003677
nucleic// //CERF// GO:0005634
transcription,
acidcomplex//binding//GO:0007420
GO:0003682
DNA-templa//////GO:0005
nucleus
DNA//bin//GG
NM_001077354
C77370expressed sequence
NM_001077354
C77370
RefSeq
Mus musculus expressed
TRUE
sequence
245555C77370
Mm.381907(C77370),
Q5DTT1
mRNA.chrX
GO:0000084mitotic// GO:0006287
S phase
GO:0005634////base-excision
GO:0006297
nucleus// GO:0043625
repair,// delta
GO:0007275
GO:0003887
gap-filling
DNA// GO:0005634
polymerase
DNA-directed////GO:0007346
nucleotide-excision
GO:0008408
complex// GO:0043625○DNA//////
GO:0007399
polymerase
GO:0003887
nucleusrepair, DNA// activity
delta////gap
GO:0043137
GO:0008408
DNA
filling// 3'-5'
polymerase//exonucmultic// G
ENSMUST00000150434
Brwd3
bromodomain
ENSMUST00000150434
and WD repeat
ENSEMBLdomainensembl_havana_transcript:novel
containing 3 TRUE
382236chromosome:GRCm38:X:108737016:108834348:-1
Mm.426127 A2AHJ4// Mm.100112
chrX// Mm.404226
GO:0007010// Mm.404234
gene:ENSMUSG00000063663
cytoskeleton// GO:0008360// Mm.413432
GO:0005575
organization// GO:0007010
cellular_component// regulation
gene_biotype:protein_coding// GO:0008360
GO:0005515
of cell shapeprotein//////
GO:0007010
GO:0003674
cytoskeletonbindingtranscript_biotype:protein_coding○ ////organization
molecular_function
GO:0008360// regulation// GO:0008150
of cell sha
NM_001077364
Tsc22d3
TSC22 domain
NM_001077364
family, member
RefSeq3
Mus musculus TSC22
TRUE domain14605
family, Mm.22216
member 3 (Tsc22d3),
Q9Z2S7 transcript
chrX variant
GO:0000122
1, mRNA.negative// GO:0006355
regulation
GO:0005634//of
GO:0006970
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0048642
GO:0003700
RNA// GO:0005634
polymerase// nucleus
sequence-specific////GO:0070236
GO:0043426
II////
promotercytoplasm
GO:0005737○ // DNA
GO:0007589// regulation
binding transcriptionof transcription,
factorDNAac
NM_019496 Ammecr1 Alport syndrome,
NM_019496
mental RefSeq
retardation, midface
Mus musculus
hypoplasia
AlportTRUE
andsyndrome,
elliptocytosis
56068
mentalchromosomal
Mm.143724
retardation,
Q9JHT5regionmidfacegenehypoplasia
chrX
1
andGO:0008150
elliptocytosis
biological_process
chromosomal
GO:0005575
region gene
cellular_component
1 (Ammecr1),
GO:0003674
mRNA.molecular_function○
XM_006528794
Ptchd1
patched domain
XM_006528794
containing
RefSeq1
PREDICTED: Mus
TRUE
musculus211612
patchedMm.218811
domain containing
Q14B62
1 (Ptchd1),
chrX transcript
GO:0007224
variant X2,
smoothened//mRNA.
GO:0050890
GO:0005886
signaling// GO:0007224
pathwayplasma// GO:0016020//membranecognition// GO:0050890
GO:0008158//////
GO:0016021
smoothened
membranehedgehog// GO:0003674//
signaling//receptor
integral
GO:0005886○
pathway
component
activity ////molecular_function
cognitionof membrane // plasm
NM_011077 Phex
phosphate regulating
NM_011077
endopeptidase
RefSeqhomolog,
Mus musculus
X-linked
phosphate
TRUE
regulating
18675 endopeptidase
Mm.2529 P70669
homolog, X-linked
chrX (Phex),
GO:0006508
mRNA. proteolysis// GO:0019637//GO:0005783
organophosphate// GO:0030282
endoplasmic// GO:0005794
metabolic// GO:0031214
GO:0004222
reticulum
process// GO:0016020//metalloendopeptidase//Golgi////GO:0006508
bone
GO:0008233
apparatus
mineralization// GO:0016021○ // membrane
GO:0008237
activity// biomineral// GO:0048471////peptidase
integral// GO:0016787
tissuecomponent
activity
developme//// G
NM_012008 Ddx3y
DEAD (Asp-Glu-Ala-Asp)
NM_012008 RefSeq
box polypeptide
Mus 3,
musculus
Y-linkedDEAD
TRUE (Asp-Glu-Ala-Asp)
26900 Mm.302938
box polypeptide
Q620953, Y-linked
chrY (Ddx3y),
GO:0006200
mRNA. ATP// GO:0008152
catabolic
GO:0005634
process //nucleus
metabolic// GO:0005737// process
cytoplasm
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0004386// RNA bin// G--H3F3A--X91866
GenBank M.musculus mRNA
TRUE
for H3.3A--- variant --histone.
P84244
chr11
GO:0006334nucleosome// GO:0007420
GO:0000786
assembly// GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr3
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_001081019
Gm12657 predicted gene
NM_001081019
12657 RefSeq
Mus musculus predicted
TRUE
gene
66725012657 (Gm12657),
Mm.449778 P84244
mRNA.
chr6
------------○
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr1
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDGSupplementary Table 5. The comparison of global mRNA expression in Mir221/222flox/y mice fed with high fat-high sucrose (HFHS) and standard (STD) chow.
m

m

Test

2Up

Control

2Downm
Feature ID
Probe Set IDExpression value
Expression{HFHSvalue
Ratio
flox/y{STD388} flox/y
Log2Ratio
378}
category
解析対象 Flag
17211066 10.85042 12.77533 0.849326-0.23561
0 main17211305 47.63595 41.28632 1.153795 0.2063869
0 main17211548 28.53265 30.91425 0.9229611 -0.115658
0 main17212947 75.26522 73.47573 1.0243548 0.0347156
0 main17214841 470.1974 594.9557 0.7903066 -0.339516
0 main17215565 90.34522 94.91344 0.9518696 -0.071164
0 main17216888 24.47034 26.84098 0.9116783 -0.133403
0 main17217291 51.58801 42.96968 1.2005677 0.2637168
0 main17217854
92.4662 97.81096 0.9453562-0.08107
0 main17217901 215.3279
238.968 0.9010742 -0.150282
0 main17220177 25.35535 38.15434 0.6645469 -0.589557
0 main17220373 197.5178 264.4885 0.7467916 -0.421222
0 main17220489 256.9431 305.6174 0.8407345 -0.250278
0 main17221158 15.44752 18.73044 0.8247281-0.27801
0 main17222440 128.7281 235.9621 0.5455457 -0.874228
0 main17223138 81.77136 102.9134 0.7945648 -0.331763
0 main17223946 15.54949
16.0907 0.966365-0.04936
0 main17225373 43.87009 27.58103 1.5905893 0.6695613
0 main17228426 309.3543 377.0215 0.8205216 -0.285387
0 main17229178 234.3915 249.8483 0.9381353 -0.092132
0 main17230469 64.60298 54.15099 1.1930157 0.254613
0 main17230602 168.3848 210.6942 0.7991905 -0.323389
0 main17230668 283.7418 311.7881 0.9100469 -0.135987
0 main17230760 51.96034 85.06554 0.6108271 -0.711164
0 main17231461 215.5273 203.6139 1.0585098 0.0820346
0 main17232483 15.28952 13.23052 1.155625 0.2086734
0 main17232734 169.2554 158.2847 1.0693099 0.0966801
0 main17233437 198.1677
215.519 0.9194906 -0.121093
0 main17233457 663.1248 1143.976 0.5796667 -0.786704
0 main17235211 219.8713 400.6118 0.5488388 -0.865546
0 main17236182 1261.031 1672.027 0.754193 -0.406994
0 main17236439
16.5119 15.49385 1.0657067 0.0918105
0 main17238449 193.3304 198.2105 0.9753792 -0.035965
0 main17238571 297.3772 268.5456 1.107362 0.147127
0 main17239234
28.0104 24.57605 1.1397438 0.1887095
0 main17240123 11.87797 11.32564 1.0487681 0.0686957
0 main17240226 378.1627 234.4308 1.6131101 0.6898449
0 main17241032 201.7627 187.1108 1.078306 0.1087667
0 main17243509 82.39014 139.9786 0.588591 -0.764663
0 main17245095 322.5288 384.7924 0.8381891 -0.254652
0 main17245188 245.1456 293.1326 0.8362959 -0.257915
0 main17245587 439.5294 454.9009 0.9662091 -0.049593
0 main17246268 48.08744 51.18897 0.9394102 -0.090173
0 main17247448 286.4043 315.9281 0.906549 -0.141543
0 main17247519 177.3747
168.062 1.0554123 0.0778067
0 main17247533 1017.681 1084.556 0.9383388 -0.091819
0 main17247550
413.364 423.2663 0.976605 -0.034153
0 main17248213
433.511 864.8309 0.5012668 -0.996349
0 main17248288 127.1214 143.4328 0.8862785 -0.174168
0 main17248476 1037.724
939.384 1.1046856 0.1436359
0 main17253307 210.5211 296.9527 0.7089382 -0.496268
0 main17254933 283.0973 393.6081 0.7192365 -0.475462
0 main17255443 257.5068 225.9709 1.1395574 0.1884735
0 main17255727 75.58215 61.25826 1.2338279 0.3031412
0 main17255775 78.28211 106.8942 0.7323326 -0.449429
0 main17255828 163.7507 181.5189 0.9021138 -0.148619
0 main17256991 44.79544
38.2034 1.1725511 0.2296508
0 main17257235 112.4936 120.3888 0.9344191 -0.097858
0 main17257801 72.32794 65.87026 1.0980364 0.1349258
0 main17258789 174.3007 226.4071 0.7698553 -0.377341
0 main17261289 53.34941 45.55436 1.1711153 0.2278832
0 main17261896 26.70852
24.7414 1.0795072 0.1103729
0 main17262055 49.51683 56.09911 0.8826669 -0.180059
0 main17262964 31.10429 28.15368 1.1048037 0.1437901
0 main17266264 647.6657 808.1497 0.801418 -0.319373
0 main17266498 243.4246 313.5163 0.7764336 -0.365065
0 main17266534
109.636 102.0037 1.0748238 0.1041001
0 main17267632 101.3317 105.6088 0.9595005 -0.059644
0 main17270621 236.9771 276.8301 0.8560381 -0.224253
0 main17272095 64.37485
96.8969 0.6643644 -0.589953
0 main17272530 986.7911 1443.771 0.6834817 -0.549025
0 main17273819 248.0828 307.9908 0.8054877 -0.312066
0 main17277017
39.7174
37.5067 1.0589415 0.0826228
0 main17277177 52.09187 48.52398 1.0735284 0.1023603
0 main17277387
115.658 250.5789 0.4615632-1.11540 main17277521 74.09139 58.45456 1.267504 0.3419903
0 main17279210 355.8349 385.0033 0.9242386 -0.113663
0 main17280913 210.4908 167.5096 1.2565895 0.3295134
0 main17281228 388.6653 432.9735 0.8976653-0.15575
0 main17284839 51.56115 54.55101 0.9451915 -0.081321
0 main17286595 342.7743 444.4544 0.7712249 -0.374776
0 main17286962
470.676 611.6155 0.7695619 -0.377891
0 main17286998 38.23375 32.43024 1.1789537 0.237507
0 main17287144 44.78688 46.63666 0.9603364 -0.058388
0 main17289196 82.20768 62.01216 1.3256703 0.406722
0 main
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m
m

Ratio flag

2Down

w

≧
≧
≦
≧

KeywordGene Accession
Gene SymbolGene Description
mRNA Accession
mRNA Source
mRna - Description
mRNA - xhybEntrezGene ID
UniGene ID SwissProt accession
ChromosomeGO BiologicalGO
Process
Biological
IDGO
Process
CellularTerm
Component
GO Cellular ID
Component
GO MolecularTerm
GO
Function
Molecular
IDmiR221/222
Function Termtarget gene
NM_177722 Mcmdc2
minichromosome
NM_177722
maintenance
RefSeqdomainMuscontaining
musculus
2 FALSEminichromosome
240697maintenance
Mm.259800
domainE9Q956containing
chr1
2 (Mcmdc2),
GO:0006260
mRNA. DNA// GO:0008150
replication
GO:0005575// biological_process
cellular_component
GO:0003677DNA// GO:0005524
binding○// ATP// GO:0003674
binding // molecular_function
NM_053191 Pi15
peptidase inhibitor
NM_053191
15
RefSeq
Mus musculus FALSE
peptidase inhibitor
94227
15 (Pi15),
Mm.442452
mRNA.
Q8BS03chr1
GO:0010466negative regulation
GO:0005576
of peptidase
extracellular
activity
GO:0030414
regionpeptidase inhibitor○
activity
NM_133235 Khdrbs2
KH domain containing,
NM_133235
RNA
RefSeqbinding, signal
Mus musculus
transduction
FALSE
KH domain
associatedcontaining,
170771
2
Mm.336594
RNA binding,
Q9WU01signal transduction
chr1
associated
GO:0006351
2 (Khdrbs2),
transcription,// GO:0006355
mRNA.
GO:0005634
DNA-templated// GO:0009967
nucleus// GO:0005634// regulation// nucleus
GO:0003723
of transcription,
RNA// GO:0005070
binding
DNA-templated○// SH3/SH2// GO:0008143//adaptor
positiveactivity//regulation
GO:0008266// poly(A)of signa// bG
NM_001164566
Spats2l
spermatogenesis
NM_001164566
associated,
RefSeqserine-richMus
2-likemusculus FALSE
spermatogenesis
67198
associated,
Mm.159989
serine-rich
Q91WJ72-like (Spats2l),
chr1transcript
GO:0008150
variantbiological_process
2, mRNA. GO:0005634nucleus// GO:0005730// nucleolus
GO:0044822// GO:0005737// cytoplasm
poly(A) RNA////GO:0043234
protein○bindingcomplex// GO:0005634// nucleus // //nucleolus
GO:0005
NM_010472 Agfg1
ArfGAP withNM_010472
FG repeats 1
RefSeq
Mus musculus FALSE
ArfGAP with FG
15463
repeats
Mm.433409
1 (Agfg1),Q8K2K6
mRNA.
chr1
GO:0001675acrosome// GO:0006810
assembly
GO:0005634// GO:0007275// transport
nucleus// GO:0016023////multicellularcytoplasmic
GO:0007283
GO:0003677// GO:0031410
organismal
membrane-bounded
DNA////GO:0007289
GO:0008060
binding//development
GO:0042995○// ARF////GO:0030154
vesicleGO:0008270
GTPase// spermatogenesis// //GO:0043025
cytoplasmic
activator////GO:0032312
GO:0046872
activity//
vesicle//GO:0043
sperma
// //
zinc
//Gc
NM_133816 Sh3bp4
SH3-domainNM_133816
binding protein
RefSeq4
Mus musculus FALSE
SH3-domain binding
98402 protein
Mm.170983
4 (Sh3bp4),
Q921I6
mRNA.chr1
GO:0006897endocytosis// GO:0008285
GO:0005634// negative// GO:0010508
regulation
nucleus// GO:0005737//ofcytoplasm
GO:0030308
cell
GO:0005092
proliferation// GO:0005905// coated
GDP-dissociation////GO:0032007//
GO:0017016
positive
pit ////GO:0016020○
membraneregulation//inhibitor//GO:0034260
GO:0042802
of////activity
cytoplasmic
autophagy
GO:0031410//////GO:0050790
GO:0005092
Ras//vesicle
negative
GTPase// GO:0070// regu
extra
//bin
//GG
NM_172485 Thsd7b
thrombospondin,
NM_172485
type I, domain
RefSeqcontaining
Mus musculus
7B
FALSE
thrombospondin,
210417type I,Mm.380518
domain containing
Q6P4U07B (Thsd7b),
chr1
mRNA.
GO:0008150biological_process
GO:0016020membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_001160268
Plekha6
pleckstrin homology
NM_001160268
domainRefSeqcontaining,Musfamilymusculus
A member
FALSE
pleckstrin
6
homology
240753domain
Mm.253559
containing,
Q7TQG1
family Achr1
member 6 (Plekha6),
GO:0008150
transcript
biological_process
variant
GO:0005575
2, mRNA.cellular_component
GO:0003674molecular_function○
ENSMUST00000070283
Dennd1b
DENN/MADDENSMUST00000070283
domain containing
ENSEMBL
1B havana:known FALSE
chromosome:GRCm38:1:138963436:139063719:1
329260 Mm.337604 Q3U1T9// Mm.475093
chr1//gene:ENSMUSG00000056268
Mm.394252
GO:0006810// Mm.474921
transport// GO:0015031//
gene_biotype:protein_coding
proteinGO:0005737// transport
GO:0032313
cytoplasm// GO:0031410// regulation// GO:0008150//GO:0005085
cytoplasmictranscript_biotype:protein_coding
of//Rab
GO:0005575
GTPaseguanyl-nucleotide//vesicle//GO:0032851
GO:0017112
activity// cellular_component
GO:0005829○ //////
exchange
biological_process
GO:0043547
GO:0017112// GO:0030136
factor////cytosol//
activity
GO:0032851
GO:0017112// positive////clathrin-c
Rabregulagua
NM_172643 Zbtb41
zinc finger and
NM_172643
BTB domain
RefSeqcontainingMus
41 musculus
homolog FALSE
zinc finger and226470
BTB domain
Mm.119711
containing
Q811F1
41 homolog
chr1(Zbtb41),GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
ENSMUST00000181811
Gm17275 predicted gene,
ENSMUST00000181811
17275 ENSEMBL ensembl_lincrna:known
FALSE chromosome:GRCm38:1:180802568:180809483:1--Mm.322735 P84244// Mm.427935
chr1
GO:0006334
gene:ENSMUSG00000097347
nucleosome// GO:0007420
GO:0000786
assembly// gene_biotype:lincRNA
GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus
transcript_biotype:lincRNA// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
NM_173378 Trp53bp2 transformation
NM_173378
related protein
RefSeq53 binding
Musprotein
musculus
2 FALSEtransformation209456
related protein
Mm.287450
53 binding
Q8CG79proteinchr1
2 (Trp53bp2),
GO:0006915
mRNA. apoptotic// GO:0007049
process
GO:0005634////GO:0007417
cell cycle
nucleus// GO:0005737// central// cytoplasm
GO:0007507
GO:0008134
nervous// GO:0048471// system
perinuclear
transcription////GO:0009792
GO:0017124
development// region
GO:0005634○
factor//of//GO:0010212
binding
GO:0042802
cytoplasm// heart// GO:0005634//development
SH3////nucleus//domain
GO:0045786
GO:0051059////
binding
GO:0005
embryonucleus////G//Gd
NM_001163754
Rab3gap2 RAB3 GTPase
NM_001163754
activatingRefSeq
protein subunit
Mus2 musculus FALSE
RAB3 GTPase98732
activating
Mm.275841
protein subunit
Q8BMG72 (Rab3gap2),
chr1
mRNA.
GO:0043087regulation// GO:0008150
of GO:0005737
GTPase// GO:0043087
activitycytoplasm// GO:0005886// biological_process// GO:0043087//GO:0005096
plasma// GO:0005737
membrane
GTPase//////GO:0043547
regulation
GO:0030234//activator//cytoplasm
GO:0005886○of GTPase
activity// GO:0046982// plasma
activity// enzyme
membrane////regulation
GO:0003674
regulator of
activity
GTPa// G
NM_001290397
Mybl1
myeloblastosis
NM_001290397
oncogene-like
RefSeq1
Mus musculus FALSE
myeloblastosis 17864
oncogene-like
Mm.4791 (Mybl1),
P51960transcript
chr1
variant 2, GO:0006351
mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated
nucleus// regulation
GO:0003677
of transcription,
DNA// GO:0003682
binding
DNA-templated○// chromatin binding
NM_019570 Rev1
REV1 homolog
NM_019570(S. cerevisiae)
RefSeq
Mus musculus FALSE
REV1 homolog56210(S. cerevisiae)
Mm.389103(Rev1),
Q920Q2
mRNA. chr1
GO:0006260DNA// GO:0006281
replication
GO:0005634////DNA
GO:0006974
repairnucleus// cellular// GO:0009411
GO:0000287
responsemagnesium//
to//GO:0042276
DNA
GO:0003677
damageion○ binding//stimulus//GO:0006261
GO:0003684// DNA// response
binding////GO:0009411
GO:0003720
to //UV
damaged// error-p// G
D
NM_001163314
Pgap1
post-GPI attachment
NM_001163314
to proteins
RefSeq1
Mus musculus FALSE
post-GPI attachment
241062 toMm.103539
proteins 1 (Pgap1),
Q3UUQ7mRNA.
chr1
GO:0006505GPI// GO:0006506
anchor metabolic
GO:0005783// GO:0006810
process
endoplasmic// GO:0016020// GPI// GO:0006886
GO:0004518
anchorreticulum// GO:0016021
biosynthetic//nuclease//membrane//GO:0007605
GO:0016787
process//activity
GO:0005783○// integral//////GO:0009880
transporthydrolase
GO:0016788
component// GO:0005783//activity
intracellular////of
GO:0009880
GO:0042578
membrane// hydrolase//protein
GO:0005////act
//
tra
en
GG
NM_010154 Erbb4
v-erb-a erythroblastic
NM_010154
leukemia
RefSeqviral oncogene
Mus musculus
homolog
FALSE
v-erb-a4 (avian)erythroblastic
13869 leukemia
Mm.442420
viralQ61527
oncogene homolog
chr1
4 (avian)
GO:0001755(Erbb4),neuralmRNA.
// GO:0006351
crest cell
GO:0005634
migration// GO:0006355
nucleus// GO:0005737
transcription,// cytoplasm
GO:0006468
GO:0000166
DNA-templated// GO:0005739// mitochondrion
nucleotide////GO:0006915
GO:0004672// binding
regulation
GO:0005886○ // //plasma//GO:0007165//GO:0004713
proteinof transcription,
membrane// GO:0005901
kinase////GO:0007169
activity
GO:0004714//DNA-templated
caveola// GO:0014// protein// //pos//GG
NM_010262 Gbx2
gastrulation brain
NM_010262
homeobox
RefSeq2
Mus musculus FALSE
gastrulation brain
14472
homeobox
Mm.204730
2 (Gbx2),
P48031
mRNA. chr1
GO:0001569patterning// GO:0001569
of GO:0005634
blood//vessels
GO:0001755
nucleus// patterning// GO:0006351
GO:0003677
of blood vessels
DNA////GO:0006355
GO:0003700
binding// neural○// crest
sequence-specific////GO:0007411
GO:0043565
cell migration// DNA
GO:0008283// transcription,binding trans// G
D
NM_001039184
Cep350centrosomal NM_001039184
protein 350 RefSeq
Mus musculus FALSE
centrosomal protein
74081350
Mm.260247(Cep350), D3YTP2
mRNA.
chr1
GO:0008150biological_process// GO:0034453
GO:0005634// microtubule
nucleus// GO:0005737
anchoring// cytoplasm
GO:0003674// GO:0005813// centrosome
molecular_function// GO:0008017// GO:0005634○// nucleus// microtubule// cytoplasm// GO:0005737
binding// centrosome// GO:0005
NM_009721 Atp1b1
ATPase, Na+/K+
NM_009721
transporting,
RefSeqbeta 1 Mus
polypeptide
musculus FALSE
ATPase, Na+/K+
11931
transporting,Mm.4550
betaP14094
1 polypeptide
chr1(Atp1b1), mRNA.
GO:0001666response// GO:0001824
to hypoxia
GO:0005886// GO:0006200// blastocyst
plasma// GO:0005890
membranedevelopment// GO:0006810
GO:0005391// //GO:0005901
sodium:potassium-exchanging// ATPsodium:potassium-exchanging////GO:0006811
GO:0005515
catabolic// GO:0016020○process////GO:0006813
GO:0023026// transport// GO:0016021
ATPaseATPase////GO:0006814//GO:0005391
complexionactivity
transport// GO:0016// //caveo
//pro
//G
ENSMUST00000159685
Gm12657 //predicted
Gm6749// ENSMUST00000159685
gene// ENSMUST00000159685
H3f3c
12657
// Gm10257// predicted
ENSEMBL// ENSMUST00000159685// pseudogene
H3f3bhavana:known// H3f3a
6749FALSE
chromosome:GRCm38:1:180810241:180813603:-1// H3 //histone,
ENSMUST00000159685
667250family 3C
Mm.449778// predicted
E0CYN1//// Mm.371797
ENSMUST00000159685
gene 10257
chr1//gene:ENSMUSG00000060743
H3
Mm.371563
histone,GO:0001649//family//ENSMUST00000159685
Mm.315189
3B
osteoblast////GO:0042692
H3 histone,// differentiation
gene_biotype:protein_coding
Mm.375617
GO:0000228
family// GO:1902340
3A//nuclear//Mm.385440//muscle
GO:0000788
chromosome//cell
GO:0006997
GO:0000979
differentiation//transcript_biotype:protein_coding
Mm.427935// GO:0001740// nuclear
RNA////GO:0090230//
GO:0000980//polymerase
negative
Mm.454661
nucleosome// GO:0005634○regulation//II//GO:0006334
core
GO:0031492// Mm.491100
Barr
promoterof// body
chromosome
GO:0043234////sequence-specific//GO:0007420
nucleus//GO:0003677
Mm.491524
condensatio// GO:0070// protein////GDG
NM_175127 Fbxo28
F-box proteinNM_175127
28
RefSeq
Mus musculus FALSE
F-box protein 28
67948(Fbxo28),
Mm.30737
mRNA. Q8BIG4
chr1
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_177389 Mia3
melanoma inhibitory
NM_177389
activity
RefSeq3
Mus musculus FALSE
melanoma inhibitory
338366activity
Mm.41152
3 (Mia3),
Q8BI84
mRNA. chr1
GO:0002063chondrocyte// GO:0002687
GO:0005783
development// GO:0006810
endoplasmic// GO:0005789
positive// GO:0006887
regulation
GO:0003674
reticulum// GO:0005789
of//leukocyte
molecular_function//endoplasmic
GO:0007162//migration
GO:0016020○reticulum// GO:0015031// transport
membrane// GO:0016021//// exocytosis
GO:0016192// endoplasmic// GO:0005// negat// reG
NM_145515 Mark1
MAP/microtubule
NM_145515
affinity-regulating
RefSeq kinase
Mus musculus
1
FALSE
MAP/microtubule
226778affinity-regulating
Mm.7445 Q8VHJ5
kinase 1 (Mark1),
chr1 mRNA.GO:0000226microtubule// GO:0001764
cytoskeleton
GO:0005737// GO:0006468
cytoplasm
organization// GO:0005856// GO:0007010//GO:0000166
cytoskeleton// neuron// GO:0005886
migration
nucleotide//////GO:0016055
GO:0000287
plasma//// protein
binding
GO:0016020
membrane○ ////
phosphorylation
GO:0016310//GO:0001786
magnesium// //membrane
GO:0005737
//ion
////
GO:0035556
GO:0004672
cytoskeletonbinding// cytoplasm// GO:0005// phosp
//org
//G
//G
NM_007956 Esr1
estrogen receptor
NM_007956
1 (alpha)
RefSeq
Mus musculus FALSE
estrogen receptor13982
1 (alpha)
Mm.9213(Esr1),// mRNA.
P19785
Mm.463262 chr10// Mm.489063
GO:0001547antral// GO:0002064
ovarianGO:0005634
follicle// GO:0006351
growthnucleus// GO:0005634// epithelial// nucleus
GO:0006355
GO:0001046
cell//development
GO:0005737// cytoplasm
core////GO:0006357
GO:0003677
promoter////transcription,cytoplasm
GO:0005737○sequence-specific////GO:0006366
GO:0003682// DNA-templated
mitochondrion// GO:0005739
DNA////GO:0007200
GO:0003700
binding////Golgi//regulation
GO:0005//apparDNA////GG
XR_380237 LOC102632938
uncharacterized
XR_380237
LOC102632938
RefSeq
PREDICTED: Mus
FALSE
musculus
102632938
uncharacterized--LOC102632938
Q8BG92
chr10(LOC102632938),--ncRNA.
----------○
NM_001168304
Cdk19
cyclin-dependent
NM_001168304
kinase 19
RefSeq
Mus musculus FALSE
cyclin-dependent
78334
kinaseMm.200924
19 (Cdk19),
Q8BWD8transcript variant
chr10 1, mRNA.
GO:0006468protein// GO:0007049
phosphorylation
GO:0005575// GO:0016310//cellular_component
cell cycle// GO:0051301//GO:0000166
phosphorylation
nucleotide////GO:0051726
GO:0004672// cellbinding
division○ ////GO:0008152//GO:0004674//protein
regulation
kinaseof//cell
activity
GO:0004693
cycle// //protein
metab
// G
NM_001193303
Lims1
LIM and senescent
NM_001193303
cell antigen-like
RefSeq domains
Mus musculus
1
FALSE
LIM and senescent
110829cellMm.57734
antigen-likeQ99JW4
domains 1 (Lims1),
chr10 transcript
GO:0007160
variant cell-matrix
3,//mRNA.
GO:0007163
adhesion
GO:0005886// GO:0016337// establishment
plasma// GO:0005925
membrane// GO:0043009
GO:0005515
or maintenance// //GO:0005925
focal
protein////adhesion
GO:0043066
of
GO:0008270
cellbinding//polarity
GO:0016020//○focal//////
zinc//GO:0045216
adhesion
GO:0046872
singleion//bindingorganismal
GO:0030054// membrane//////
GO:0045892
GO:0008270
metal
cell-cell//ion
GO:0043// celladhesibinding//jun
G
NM_011240 Ranbp2
RAN bindingNM_011240
protein 2 RefSeq
Mus musculus FALSE
RAN binding protein
193862 Mm.431695(Ranbp2), mRNA.
Q9ERU9chr10
GO:0006457protein// GO:0006810
folding
GO:0005634// transport// GO:0015031
nucleus//// GO:0005643
protein// nuclear
GO:0033132
transport
GO:0003723//pore
GO:0005739// negative//RNA//mitochondrion//GO:0046907
GO:0003755
binding
regulation// GO:0016020○// peptidyl-prolyl//////
of
GO:0051028
membrane
GO:0005515
glucokinase// GO:0031965
cis-trans// activity//
nuclear//GO:0090526
GO:0008270
isomerase
membrane//// intracellula
GO:0031//act//GG
NM_021565 Midnmidnolin
NM_021565 RefSeq
Mus musculus FALSE
midnolin (Midn),
59090
mRNA.
Mm.143813 Q3TPJ7
chr10
GO:0033132negative// GO:0046676
regulation
GO:0005634//of
GO:0033132
glucokinase
nucleus// GO:0005730//
activity
nucleolus
GO:0046676
GO:0019900////negative
GO:0005730// nucleolus
kinase// regulation
GO:0019900
binding//// GO:0005829
cytosol○of //insulin
kinase// nucleus
secretionbinding// GO:0005634// nucleolus// negative// GO:0005
regulatio
NM_011595 Timp3
tissue inhibitor
NM_011595
of metalloproteinase
RefSeq 3 Mus musculus FALSE
tissue inhibitor 21859
of metalloproteinase
Mm.4871 P39876
3 (Timp3), mRNA.
chr10
GO:0010466negative// GO:0045861
regulation
GO:0005576//of
GO:0051045
peptidase
extracellular// GO:0005578
activity// GO:0071310
GO:0004857
region// negative// //GO:0005604
proteinaceous
enzyme//regulation//GO:0010951
GO:0008191
inhibitor// GO:0005634
extracellularof○proteolysis//activity//GO:0051045
GO:0030414
matrix////// metalloendopeptidase
GO:0005737
negative// basement// GO:0046872
regulation// GO:0031
membranof inhimem
NM_001128086
Anks1bankyrin repeat
NM_001128086
and sterileRefSeq
alpha motif domain
Mus musculus
containing
FALSE
ankyrin
1B repeat and77531
sterileMm.440605
alpha motif
Q8BIZ1domain containing
chr10 1B (Anks1b),
GO:0008150
transcript
biological_process
variant
GO:0005634
1, mRNA. nucleus// GO:0005737// cytoplasm
GO:0046875// GO:0005886// plasma
ephrin// GO:0046875
receptor
membrane// GO:0016020○ binding// membrane////ephrin
GO:0030054
receptor// cell junction
binding// GO:0042// ce
NM_172790 Ankrd52
ankyrin repeat
NM_172790
domain 52RefSeq
Mus musculus FALSE
ankyrin repeat237615
domain Mm.440177
52 (Ankrd52),
Q8BTI7
mRNA. chr10
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
NM_028873 Dnajc14
DnaJ (Hsp40)
NM_028873
homolog, subfamily
RefSeq C, member
Mus musculus
14 FALSE
DnaJ (Hsp40) homolog,
74330 Mm.296915
subfamily C,
Q921R4member 14
chr10(Dnajc14),GO:0006810
mRNA.
transport// GO:0015031// protein
GO:0005783// transport
GO:0008150
endoplasmic// GO:0016020// biological_process
GO:0001664
reticulum// GO:0016021//G-protein
membrane// GO:0050780//coupled
GO:0005789○// integral
receptor
componentbinding of//membrane
dopamine recep// en
NM_001114333
Grm1
glutamate receptor,
NM_001114333
metabotropic
RefSeq 1 Mus musculus FALSE
glutamate receptor,
14816metabotropic
Mm.4829861P97772(Grm1), transcript
chr10 variantGO:0000186
2, mRNA. activation// GO:0000187
of MAPKK
GO:0005634// GO:0007165
activity
nucleus// GO:0005886// activation// plasma
GO:0007186
GO:0001639
of//membrane
MAPK
GO:0005887
PLC//activity//GO:0007205
GO:0004871
activating// integral// GO:0014069
signal
○ G-protein
component//transduction//GO:0007206
GO:0004930
coupled// GO:0014069
of plasma// //G-protein
glutamate//GO:0007216
GO:0005515
membrane// coupled
GO:0016
receptor//////GrepG
XM_006512693
Clvs2
clavesin 2 XM_006512693
RefSeq
PREDICTED: Mus
FALSE
musculus215890
clavesinMm.94461
2 (Clvs2), transcript
Q8BG92variant
chr10
X1, mRNA.
GO:0006810transport// GO:0007040// lysosome
GO:0005622// GO:0007040
organization
intracellular// GO:0005768// lysosome
GO:0005215// endosome// GO:0005794
organizationtransporter//// Golgi
GO:0008289
apparatus// GO:0005802
activity○ // //GO:0080025//lipidtrans-Golgi//binding
GO:0016020
network//// GO:0080025
phosphatidylinos////GO:0030
membra// G
NM_008538 Marcks
myristoylatedNM_008538
alanine richRefSeq
protein kinaseMus
C musculus
substrate FALSE
myristoylated alanine
17118 rich
Mm.30059
protein kinase
P26645
C substratechr10(Marcks),--- mRNA. --GO:0005737cytoplasm// GO:0005813//GO:0003779
centrosome// GO:0005856
actin//// cytoskeleton
GO:0005080
binding// GO:0005938○// protein////cell
GO:0005515
cortexkinase// GO:0016020//
C membranebinding// GO:0005516//// protein
GO:0042// germin
bin
NM_029083 Ddit4
DNA-damage-inducible
NM_029083transcript
RefSeq 4 Mus musculus FALSE
DNA-damage-inducible
74747 Mm.21697
transcript 4Q9D3F7(Ddit4), mRNA.
chr10
GO:0001666response// GO:0001666
to hypoxia
GO:0005622// GO:0001764// response
intracellular// GO:0005622
to//hypoxia
GO:0006915
GO:0071889// intracellular////GO:0005737
neuron14-3-3// //GO:0007420
migrationcytoplasm
protein// GO:0005739○//binding//
apoptotic//mitochondrion
GO:0008283//
process
GO:0005622//// //GO:0009968
intracellular
brain //developme
GO:0005////cytG
NM_010914 Nfyb
nuclear transcription
NM_010914
factor-Y
RefSeqbeta
Mus musculus FALSE
nuclear transcription
18045factor-Y
Mm.245998
beta (Nfyb),
P63139mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005622
DNA-templated// GO:0045893
intracellular// GO:0005634// regulation// GO:0006355
GO:0003677// nucleusof// GO:0005634
transcription,//DNA
nucleus// GO:0003677
binding
DNA-templated//// GO:0005667
transcription○// DNA// GO:0003700
bindingfactor//// positive
GO:0016602//complex
sequence-specific//regulation
GO:0032403////CCAAT-bin
GO:0005of trans//
DN
G
NM_001037848
Cnot2
CCR4-NOT transcription
NM_001037848
RefSeqcomplex, subunit
Mus musculus
2
FALSE
CCR4-NOT transcription
72068 Mm.351553
complex, subunit
Q8C5L32 (Cnot2),
chr10 transcript
GO:0000122
variant 4,negativemRNA.
// GO:0001829
regulation
GO:0005634//of
GO:0006351
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0006355
GO:0001226
RNA// GO:0030014
polymerase// CCR4-NOT
RNA////GO:0006417
GO:0004535
polymerase
II //promoter
GO:0005737
complex○ //II//GO:0007275//
transcription
GO:0001226//
trophectodermal
cytoplasm// GO:0005737
corepressor//////
GO:0010606
GO:0001226
cytoplasm
cell //differentiati
GO:0030
binding////CC//GG
NM_177798 Frs2
fibroblast growth
NM_177798
factor receptor
RefSeqsubstrate
Mus2musculus FALSE
fibroblast growth327826factorMm.135965
receptor substrate
Q8C1802 (Frs2),
chr10
mRNA. GO:0000187activation// GO:0001702
of MAPK
GO:0005737// activity
GO:0001759
cytoplasm////GO:0005886
gastrulation// GO:0002088//GO:0005068
plasmawith// GO:0005911
membranemouthtransmembrane////GO:0003281
forming
GO:0005104////cell-cell
GO:0016020
second○ receptor////junction
GO:0007169
GO:0005158// organ
protein//induction
membranetyrosine////GO:0007405
GO:0005168// kinaselens develop
adapt////GG
NM_001163024
Mon2
MON2 homolog
NM_001163024(yeast) RefSeq
Mus musculus FALSE
MON2 homolog67074(yeast)Mm.169924(Mon2), transcript
Q80TL7variant
chr10
1, mRNA. GO:0006810transport// GO:0015031// protein
GO:0005802// transport
GO:0016192
trans-Golgi// GO:0005802// vesicle-mediated// GO:0030036
network
GO:0005086// trans-Golgi
transport
ARF////GO:0043087
GO:0005086
guanyl-nucleotide//networkactin○ cytoskeleton// GO:0006895
exchangeorganization//factor
GO:0016192
activity// regulatio// //ARG
NM_011772 Ikzf4
IKAROS family
NM_011772
zinc fingerRefSeq
4
Mus musculus FALSE
IKAROS family22781
zinc finger
Mm.358648
4 (Ikzf4),Q8C208
mRNA.
chr10
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// regulation// GO:0045944
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0005515// DNA// negative
binding// regulation
GO:0042803// protein ofbinding
tran// G
ENSMUST00000154425
Ppp3r1protein phosphatase
ENSMUST00000154425
3, regulatory
ENSEMBL
subunithavana:known
B, alpha isoform
FALSE
chromosome:GRCm38:11:17192844:17195109:1(calcineurin
19058
B, typeMm.41840
I)//Q63810
Mm.401506chr11//gene:ENSMUSG00000033953
Mm.474050
GO:0001569patterning// GO:0001837
gene_biotype:protein_codingof GO:0005622
blood//vessels
GO:0006470
intracellular////GO:0005623
epithelial// GO:0006470
GO:0004721//transcript_biotype:processed_transcripttocellmesenchymal// //GO:0005737
cytoplasm
phosphoprotein////GO:0007507
GO:0004721
transition// //plasma
GO:0005886○ phosphatase////membrane//protein
GO:0034504
GO:0005509//dephosphorylation
GO:0016020
activity// membrane////GO:0051531
GO:0005515// phosphoprote// GO:0042// //sarcole
protein////GG
NM_033523 Spred2
sprouty-related,
NM_033523
EVH1 domain
RefSeqcontaining
Mus2musculus FALSE
sprouty-related,
114716
EVH1 Mm.266627
domain containing
Q924S72 (Spred2),
chr11 mRNA.GO:0000188inactivation// GO:0007275
of
GO:0005634
MAPK// GO:0009966
activity
nucleus// GO:0005737// multicellular// cytoplasm
GO:0010801
GO:0005173//organismal
GO:0005886// plasma
stem////GO:0010801
GO:0005515
celldevelopment
membrane//factor
GO:0016020○ receptor////GO:0043517////
GO:0019901
membraneregulation
binding// GO:0031410
of//////signal
GO:0071901
proteincytoplasmic
GO:0019901
transduction//binding
GO:0005vesic//////GG
ENSMUST00000132285
Rab1
RAB1, member
ENSMUST00000132285
RAS oncogene
ENSEMBLfamilyhavana:known FALSE
chromosome:GRCm38:11:20201439:20219487:1
19324 Mm.271944 P62821// Mm.368433
chr11
gene:ENSMUSG00000020149// Mm.471872
GO:0000045// Mm.486775
autophagic// GO:0006184
gene_biotype:protein_coding// Mm.491009
vacuoleGO:0000139// assembly
GO:0006810
Golgi// GO:0005622//membrane
GTP// GO:0006886
GO:0000166
catabolictranscript_biotype:processed_transcript// intracellular
GO:0005623
process
nucleotide////GO:0006888
GO:0003924////transport//cellbinding
GO:0005737○// cytoplasm//////GO:0006897//GO:0005515
intracellular
GTPase// GO:0005768// endosome
activity
protein////GO:0006914
GO:0005525// transport
protein//// early
GO:0005bindinendo//////GEGENSMUST00000101477
Peli1
pellino 1
ENSMUST00000101477
ENSEMBL havana:known FALSE
chromosome:GRCm38:11:21135469:21150323:1
67245 Mm.28957 //Q8C669
Mm.403029chr11//gene:ENSMUSG00000020134
Mm.408019
GO:0000209// Mm.408628
protein// GO:0001819
polyubiquitination
gene_biotype:protein_coding
GO:0005634// GO:0008063
nucleus// positive// regulation
GO:0030890
GO:0004842
transcript_biotype:protein_codingof cytokine
ubiquitin-protein////GO:0031398
GO:0005515
production○ transferase////GO:0032088//GO:0008766
Toll signaling
activity////GO:0032496
pathway
GO:0016874// protein//binding
positiv////GG
NM_001290676
Cpeb4
cytoplasmic polyadenylation
NM_001290676
RefSeqelement binding
Mus musculus
protein FALSE
4cytoplasmic polyadenylation
67579 Mm.339792
element
Q7TN98binding protein
chr114 (Cpeb4),
GO:0002931
transcriptresponse
variant// GO:0035235
2,tomRNA.
ischemia
GO:0005634// GO:0036294// ionotropic
nucleus// GO:0005634//glutamate
nucleus
GO:0042149
GO:0000166// GO:0005737//
receptorcytoplasm
nucleotide////GO:0043524
GO:0003676
signaling////cytoplasm
binding
GO:0005737○
pathway////GO:0071230//GO:0003723
nucleic////endoplasmic
cellular// GO:0005783
acidresponse//binding//GO:0071230
GO:0044822
reticulum//to//GO:0014
RNA
decrease// //posbin//GG
NM_177364 Sh3pxd2b SH3 and PXNM_177364
domains 2BRefSeq
Mus musculus FALSE
SH3 and PX domains
268396 2B
Mm.227616(Sh3pxd2b),
A2AAY5
mRNA. chr11
GO:0001501skeletal// GO:0001501
system
GO:0002102
development// GO:0001654
podosome// GO:0005737// skeletal// GO:0001654//GO:0010314
cytoplasm
system// GO:0030054
development
phosphatidylinositol-5-phosphate//////cell
GO:0006801
GO:0032266
junction// GO:0042995//○eye// //cell
development//GO:0007507
GO:0035091
projection// GO:0002102////
bindingeyepodosome//GO:0007507
GO:0042169
development// phosphat
GO:0005// cytop////G//G
NM_145962 Pank3
pantothenateNM_145962
kinase 3 RefSeq
Mus musculus FALSE
pantothenate 211347
kinase 3 Mm.255044(Pank3), mRNA.
Q8R2W9 chr11
GO:0015937coenzyme// GO:0016310
A GO:0005737
biosynthetic// GO:0015937
cytoplasm
process// GO:0005737//// GO:0016310//
phosphorylation
GO:0000166
cytoplasm nucleotide// //GO:0004594
coenzyme
binding○ A //biosynthetic//GO:0005524
pantothenate
process//kinase
GO:0016301// activity
phosphoryl//// AG
NM_001024205
Nufip2
nuclear fragile
NM_001024205
X mental retardation
RefSeq protein
Mus musculusinteractingFALSE
nuclearproteinfragile
2
X
68564
mentalMm.428996
retardation Q5F2E7protein interacting
chr11 protein---2 (Nufip2), --mRNA.
GO:0005634nucleus// GO:0005737// cytoplasm
GO:0003723// GO:0042788// polysomal
RNA// GO:0044822
binding//ribosome
GO:0005634○// poly(A)// GO:0003723// nucleus
RNA// GO:0005634
binding// nucleus// GO:0003723// RNA////GO:0005
cytoplasbinding
NM_016686 Vezf1
vascular endothelial
NM_016686
zinc finger
RefSeq1
Mus musculus FALSE
vascular endothelial
22344zinc
Mm.46628
finger 1 (Vezf1),
Q5SXC3mRNA.
chr11
GO:0001525angiogenesis// GO:0001885
GO:0005634// endothelial
nucleus//cell
GO:0005634
development// nucleus
GO:0003676nucleic// GO:0046872
acid ○
binding // metal ion binding
NM_201609 Zfp652
zinc finger protein
NM_201609
652 RefSeq
Mus musculus FALSE
zinc finger protein
268469652 Mm.389038(Zfp652), mRNA.
Q5DU09// Mm.418731
chr11
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_001081434
Osbpl7
oxysterol binding
NM_001081434
protein-like
RefSeq7
Mus musculus FALSE
oxysterol binding
71240
protein-like
Mm.190450
7 (Osbpl7),
A2A716
mRNA.chr11
GO:0006810transport// GO:0006869// lipid
GO:0005776
transport// GO:0071397
autophagic// GO:0005829
cellular// GO:1901800
vacuoleresponse
GO:0015485// GO:0005886//tocytosol
cholesterol
cholesterol////GO:0071397
GO:0015485// plasma// //GO:0097038
binding○
positivemembrane// GO:1901800//regulation
cholesterol// GO:0005776// perinuclearof binding
proteasomal
endoplasmic// GO:0005
protein
NM_138657 Socs7
suppressor ofNM_138657
cytokine signaling
RefSeq7
Mus musculus FALSE
suppressor of 192157
cytokine Mm.34339
signaling 7 (Socs7),
Q8VHQ2mRNA.
chr11
GO:0008286insulin// GO:0009968
receptor
GO:0005634
signaling// GO:0016567
nucleuspathway// GO:0005730////nucleolus
GO:0035556
negative--- // GO:0005737
regulation// cytoplasm--// GO:0040008
of signal////GO:0005886
plasma○ transduction// GO:0045444
membrane// GO:0016020// protein////membrane
GO:0016567
ubiquitination// GO:0043// intrac/
NM_139311 Mllt6
myeloid/lymphoid
NM_139311
or mixed-lineage
RefSeq leukemia
Mus musculus(trithorax
FALSE
myeloid/lymphoidhomolog, Drosophila);
246198or mixed-lineage
Mm.23685
translocatedB1AR09
leukemia
to, 6(trithorax
chr11 homolog,
GO:0008150
Drosophila);
biological_processtranslocated
GO:0005575
to, 6 (Mllt6),
cellular_component
mRNA. GO:0046872metal// GO:0003674
ion binding○ //// GO:0008270
molecular_function // zinc ion bin
NM_001110778
Adam11a disintegrin NM_001110778
and metallopeptidase
RefSeq domain
Mus musculus
11
FALSE
a disintegrin and
11488
metallopeptidase
Mm.89854 domain
Q9R1V411 (Adam11),
chr11
transcript
GO:0006508
variantproteolysis//
1, GO:0007229
mRNA. //GO:0016020
integrin-mediatedmembrane// GO:0016021
signaling//GO:0004222
integralpathway
component
metalloendopeptidase// GO:0005515
of membrane○ // GO:0008237
activity // protein// GO:0008270
binding // me
NM_016780 Itgb3
integrin beta NM_016780
3
RefSeq
Mus musculus FALSE
integrin beta 3 16416(Itgb3), Mm.87150
mRNA.
O54890
chr11
GO:0001938positive// GO:0002687
regulation
GO:0005634//ofGO:0006457
endothelial
nucleus// GO:0005886
cell// plasma
GO:0006874
proliferation
GO:0003756//membrane
GO:0005925//protein//positive//GO:0007044
GO:0004872// disulfide
focal//
regulation
GO:0008305○
adhesion
isomerase////GO:0007155
of
GO:0005178
leukocyte// integrin// activity
GO:0009897
migration//complex//GO:0007160//GO:0005515
receptor//////GO:0009
proteinexternal
activity////GfoG
NM_015732 Axin2
axin2
NM_015732 RefSeq
Mus musculus FALSE
axin2 (Axin2), mRNA.
12006 Mm.71710 O88566
chr11
GO:0001756somitogenesis// GO:0001934
GO:0005622// positive// GO:0001957
intracellular
regulation// GO:0005634// of
GO:0003139
GO:0004871//protein
nucleus// GO:0005634
phosphorylation//signal//nucleus//GO:0003413
GO:0005096
transducer//// GO:0005737
cytoplasm○// intramembranous//activity//GO:0006355
GO:0005515// centrosome//// GO:0005813
GTPaseossification////GO:0007275
GO:0008013
activator// centrosome// GO:0005//activity
secon////GG
NM_198022 Tnrc6c
trinucleotide NM_198022
repeat containing
RefSeq
6C
Mus musculus FALSE
trinucleotide repeat
217351
containing
Mm.40272
6C (Tnrc6c),
Q3UHC0mRNA.
chr11
GO:0001706endoderm// GO:0006417
formation
GO:0005575// GO:0007492// regulation
cellular_componentof// translation
GO:0031047
GO:0000166// endoderm
nucleotide////GO:0035162
GO:0003676
development
binding○ ////GO:0048568//GO:0003723
nucleic// geneacid
silencing//binding//GO:0060213
GO:0003674
by// RNA
RNA//bin//Ge
NM_146016 Eml6
echinoderm microtubule
NM_146016associated
RefSeqproteinMus musculus
like 6
FALSE
echinoderm microtubule
237711 Mm.445271
associatedQ5SQM0
protein like 6
chr11(Eml6), mRNA.
GO:0008150biological_process
GO:0005737cytoplasm// GO:0005856//GO:0003674
cytoskeleton// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_010250 Gabra1
gamma-aminobutyric
NM_010250
acidRefSeq(GABA) A receptor,
Mus musculus
subunit
FALSE
gamma-aminobutyricalpha 1
14394 acid
Mm.439668(GABA) P62812
A receptor, subunit
chr11 alphaGO:0006810
1 (Gabra1), transportmRNA.
// GO:0006811// ion
GO:0005886
transport// GO:0006821
plasma////chloride
GO:0005887
membrane// transport
GO:0007165
GO:0004890// //GO:0016020//integral
signalGABA-A////GO:0007214
GO:0005216
transduction
component//
receptor
GO:0016021
○ of
////
activity//GO:0051932
plasma
GO:0005230
gamma-aminobutyric////membrane
GO:0030054
ion channel////GO:0034220
GO:0005254// activity
membrane//acid
GO:0034
signali//////ext
GG
NM_172524 Nipal4
NIPA-like domain
NM_172524
containing
RefSeq4
Mus musculus FALSE
NIPA-like domain
214112
containing
Mm.225253
4 (Nipal4),
Q8BZF2
mRNA.chr11
GO:0006810transport// GO:0006811// ion
GO:0016020
transport// GO:0015693
membrane////magnesium
GO:0016021// GO:0015693//GO:0015095
integralion//transport
GO:0005575
component
magnesium// GO:0003674// magnesiumof membraneion○ transmembrane
ion transport// cellular_component
transporter activity //NM_001029988
Fat2
FAT tumor suppressor
NM_001029988
homolog
RefSeq2 (Drosophila)
Mus musculus FALSE
FAT tumor suppressor
245827 Mm.339363
homolog 2 (Drosophila)
Q5F226(Fat2),
chr11 mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005634// homophilic// GO:0010631
nucleus//cell
GO:0005886
adhesion// plasma
GO:0007156
GO:0005509////membrane
epithelial
GO:0005913
calcium// GO:0007156
cell// migration
cell-cellion// GO:0016020
binding○ adherens////GO:0010631
homophilic//junction
GO:0016021
cell
// //
GO:0010631
adhesionmembrane// GO:0030// homo// in
NM_144825 Taok1
TAO kinase 1NM_144825 RefSeq
Mus musculus FALSETAO kinase 1216965(Taok1),Mm.340436
mRNA.
Q5F2E8chr11
GO:0000165MAPK// GO:0000186
cascadeGO:0005737////activation
GO:0006281
cytoplasm// of
GO:0070062
MAPKK// GO:0006468//GO:0000166
extracellular
activity// GO:0005737// nucleotide
DNA//vesicular//GO:0006915
GO:0004672
repair//exosomebinding
GO:0005737○// protein////GO:0006950//GO:0004674//protein
phosphorylation
cytoplasm
kinase//////GO:0006974
activitycytoplasm
GO:0004709// apoptotic// protein
//pro
//GG
NM_008702 Nlk
nemo like kinase
NM_008702 RefSeq
Mus musculus FALSE
nemo like kinase
18099(Nlk),Mm.9001
mRNA.
O54949chr11
GO:0000165MAPK// GO:0006351
cascadeGO:0005634////transcription,
GO:0006355
nucleus// GO:0005737
DNA-templated// cytoplasm
GO:0006468
GO:0000166// GO:0005634// //nucleus
nucleotide//regulation//GO:0007179
GO:0000287
bindingof○transcription,////GO:0016055//GO:0004672
magnesium
DNA-templated//ion//GO:0016310
GO:0004674
binding// protein// prote////GG
NM_013571 Ksr1
kinase suppressor
NM_013571
of ras 1RefSeq
Mus musculus FALSE
kinase suppressor
16706
of rasMm.4745
1 (Ksr1), mRNA.
Q61097chr11
GO:0006468protein// GO:0016310
phosphorylation
GO:0005737// GO:0035556//cytoplasm
phosphorylation// GO:0005783// GO:0043410//GO:0004672
endoplasmic//// GO:0016020
intracellular
protein
reticulum// GO:0004674
signalkinase// GO:0005789//○transduction
membrane
activity// GO:0005078// protein////endoplasmic
positiveserine/threonine// GO:0005515
regulation
reticulum
ofkinasMA//mG
NM_019505 Dgke
diacylglycerolNM_019505
kinase, epsilon
RefSeq
Mus musculus FALSE
diacylglycerol kinase,56077 epsilon
Mm.153695(Dgke),
Q9R1C6
mRNA. chr11
GO:0007205protein// GO:0008152
kinase
GO:0005737
C-activating// GO:0016310
cytoplasm//
G-protein
GO:0016020// GO:0035556//coupled
GO:0000166
membrane// GO:0016021
receptor
nucleotide////integral
GO:0003951
signaling//component
binding
GO:0005737○
pathway// //GO:0004143
NAD+of// membrane
metabolic// GO:0016020
kinase//activity
process
GO:0005524// cytoplasm////diacylgl
phosph//// mG
NM_001081045
Kansl1
KAT8 regulatory
NM_001081045
NSL complex
RefSeqsubunitMus
1 musculus FALSE
KAT8 regulatory
76719
NSL complex
Mm.136418
subunit
Q80TG11 (Kansl1),
chr11
mRNA. GO:0016568chromatin// GO:0043981
modification
GO:0000123// GO:0043982//histone
histone// GO:0005634
acetyltransferase
H4-K5// GO:0043984
GO:0043995
acetylation// GO:0071339
histonecomplex////GO:0043981//GO:0043996
histoneacetyltransferase//// GO:0000123
nucleusH4-K8○ ////GO:0043981
acetylation
GO:0046972// MLL1
activity// GO:0000123
complex//(H4-K5//histone//GO:0043982
GO:0043995// specific)
histoneH4-K16// GO:0005
acety
//ace
////GhG
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus FALSE
H3 histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244
chr11
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_011358 Srsf2
serine/arginine-rich
NM_011358
splicing
RefSeqfactor 2 Mus musculus FALSE
serine/arginine-rich
20382
splicing
Mm.21841
factor 2//Q62093(Srsf2),
Mm.469331
mRNA.
chr11
GO:0006397mRNA// GO:0008380
processing
GO:0005634// RNA
nucleus//splicing
GO:0005634// nucleus
GO:0000166// GO:0005681// spliceosomal
nucleotide// GO:0003676//complex
binding
GO:0016607○ // //GO:0003723//nucleic
nuclear// GO:0016607
acid
speck
binding// GO:0005515// nuclear////GO:0005
RNA
speck
bin
// G
NM_001099628
Atad2bATPase family,
NM_001099628
AAA domain
RefSeqcontainingMus
2Bmusculus FALSE
ATPase family,
320817AAA domain
Mm.210966
containing
E9Q1662B (Atad2b),
chr12 mRNA.GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleusprocess
GO:0000166nucleotide// GO:0005524
binding○ // //GO:0070577
ATP binding ////GO:0017111
lysine-acetylated// G
XM_006516065
Rgs6
regulator of G-protein
XM_006516065
signaling
RefSeq6
PREDICTED: Mus
FALSE
musculus regulator
50779 Mm.153013
of G-proteinQ9Z2H2
signaling 6 chr12(Rgs6), transcript
GO:0007165
variant signal
X2,// GO:0007186
mRNA.
transduction
GO:0005737// //GO:0009968
G-proteincytoplasm// GO:0005794
coupled// GO:0035556//GO:0004871
Golgi
receptor//apparatus
GO:0005834
signaling
signal////GO:0038032
GO:0005096//transducer
heterotrimericpathway// GO:0005886○ //activity//GO:0043547
GO:0005096
negative
G-protein//// GO:0016020
GTPaseregulation
complex////GO:0045666
GO:0005515
activator
of////signal
plasma
GO:0043
activity
trans
////m
GG
NM_028821 Dnal1
dynein, axonemal,
NM_028821
light chain
RefSeq1
Mus musculus FALSE
dynein, axonemal,
105000lightMm.101525
chain 1 (Dnal1),
Q05A62
mRNA.chr12
GO:0008150biological_process
GO:0005575cellular_component
GO:0003674molecular_function○
ENSMUST00000134311
Fos
FBJ osteosarcoma
ENSMUST00000134311
oncogene
ENSEMBL havana:putativeFALSE
chromosome:GRCm38:12:85474911:85476063:1
14281 Mm.246513 P01101// Mm.472279
chr12
gene:ENSMUSG00000021250
GO:0006355regulation// GO:0006355
gene_biotype:protein_codingof GO:0005634
transcription,// GO:0006366
nucleus
DNA-templated// GO:0005634// nucleus
GO:0007179
GO:0000979
transcript_biotype:processed_transcript// regulation
GO:0005634// nucleus
RNA////GO:0007399
GO:0003677
ofpolymerase// transcription,transcription// GO:0005667○ //II//GO:0031668
core
GO:0003677
factorDNA-templated
promoter// complex
GO:0005737//sequence-specific//GO:0034614
GO:0003690////cytoplasm
transcription// GO:0005//////GeDG
NM_177354 Vash1
vasohibin 1 NM_177354 RefSeq
Mus musculus FALSE
vasohibin 1 (Vash1),
238328mRNA.
Mm.216101 Q8C1W1 chr12
GO:0001525angiogenesis// GO:0001937
GO:0005576// negative// GO:0007049
extracellular
regulation// GO:0005615//of
GO:0007050
GO:0003674
regionendothelial// //GO:0005737
extracellularcellmolecular_function// GO:0009611
proliferation//
space
GO:0005783○ //// cell
cytoplasm
GO:0010596
cycle// GO:0045177// //cell
endoplasmic// cycle
GO:0010628
arrest// GO:0005
reticulum
// //
resp
G
NM_001025358
Klc1
kinesin light chain
NM_001025358
1
RefSeq
Mus musculus FALSE
kinesin light chain
16593
1 (Klc1),
Mm.278357
transcript
O88447variant b, chr12mRNA.
GO:0006886intracellular// GO:0007018
proteinGO:0005622// transport
GO:0008088
intracellular// GO:0005623// microtubule-based// GO:0035418
GO:0003777// cell// //GO:0005737
cytoplasm
microtubule//
movement//GO:0035617
GO:0005515// //cytosol
GO:0005829
motor○// axon////GO:0008152
activitycargo
GO:0015631
cytoskeleton//transport//GO:0005856
protein//////GO:0006886
kinesin//GO:0015631
binding
protein// complex
GO:0005//localizat
tubulin// G
NM_021361 Nova1
neuro-oncological
NM_021361
ventral RefSeq
antigen 1 Mus musculus FALSE
neuro-oncological
664883ventralMm.247195
antigen 1 Q9JKN6(Nova1), mRNA.
chr12
GO:0000398mRNA// GO:0000398
splicing,
GO:0005634
via// spliceosome
GO:0007399
nucleus// GO:0005634//// mRNA
nucleus
GO:0051252
GO:0003723
splicing,// GO:0005730// nucleolus
RNA
via// GO:0003729
spliceosome
binding// //intracellular
GO:0043231○// mRNA////GO:0005515
nervousmembrane-boundedbinding// GO:0005634
system// protein// GO:0044822
development
binding
organelle////pNM_001003719
Ralgapa1 Ral GTPase NM_001003719
activating protein,
RefSeqalpha subunit
Mus musculus
1
FALSE
Ral GTPase activating
56784 Mm.292180
protein, alphaQ6GYP7subunit 1 (Ralgapa1),
chr12transcript
GO:0006355
variant
regulation// GO:0032853
3, mRNA.
of GO:0005634
transcription,// GO:0032859
nucleus
DNA-templated// GO:0005737// cytoplasm
GO:0051056
GO:0005096// positive
GO:0005634// nucleus
GTPase////GO:0032859
regulation
GO:0005098//activator//cytoplasm
GO:0005737○
of Ran//activity//GO:0032859
GO:0005515
GTPase// mitochondrion//// GO:0005739
Ran
activity
GTPase// GO:0017123// activation
activatorof//acR
G
NM_177290 Itgb8
integrin beta NM_177290
8
RefSeq
Mus musculus FALSE
integrin beta 8320910(Itgb8), Mm.217000
mRNA.
Q0VBD0chr12
GO:0001573ganglioside// GO:0007155
metabolic
GO:0016020// GO:0007229
process
membrane// GO:0016021// cell// GO:0007160//
adhesion
GO:0005102
integral// GO:0070062
component// integrin-mediatedreceptor////GO:0007275
GO:0004872
ofbinding// membrane
GO:0008305○ signaling////receptor
GO:0005102// extracellularpathway
activity // vesicular
receptorcell-matrix
bindinexosomadh
NM_001039188
Rreb1
ras responsive
NM_001039188
element binding
RefSeqproteinMus
1 musculus FALSE
ras responsive 68750
elementMm.491109
binding protein
Q3UH061 (Rreb1),
chr13
transcript variant
GO:0006351
2, mRNA.
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0045892
nucleus// GO:0005737// regulation// cytoplasm
GO:0003676
of// GO:0070062
transcription,// extracellular
nucleic// GO:0003677
acid
DNA-templated// GO:0005634
vesicular○binding// GO:0003700//exosomeDNA//// negative
GO:0016607
binding// nucleus// regulation
GO:0046872// sequence-spe// nuclearof trans
NM_153789 Mylip
myosin regulatory
NM_153789
light chain
RefSeqinteractingMus
proteinmusculus FALSE
myosin regulatory
218203lightMm.212855
chain interacting
Q8BM54protein chr13(Mylip), mRNA.
GO:0006928cellular// GO:0007399
component
GO:0005622// movement
GO:0010989
intracellular// GO:0005737// nervous// GO:0016567
GO:0004842// cytoplasm
system// GO:0005856
development
ubiquitin-protein//////GO:0016567
cytoskeleton
GO:0004842// GO:0005886○// negativetransferase////GO:0031648
plasma
GO:0008092
regulation//membrane
GO:0016020
activity////of
GO:0032803
GO:0008270//low-density
ubiquitin-protei// membrane// GO:0019
lipop////GG/
NM_001081425
Rbm24
RNA bindingNM_001081425
motif proteinRefSeq
24
Mus musculus FALSE
RNA binding motif
666794proteinMm.38269
24 (Rbm24),
D3Z4I3
mRNA. chr13
GO:0010830regulation// GO:0030154
of GO:0005634
myotube// GO:0043488
differentiation
nucleus// GO:0005737// cytoplasm//GO:0000166
cell differentiation// GO:0005575// cellular_component
nucleotide// GO:0003676// regulation
binding○ // //
of
GO:0003723
nucleic
mRNA acidstability
binding// GO:0003730// RNA bin
AK029314 Tes3-ps
testis derivedAK029314
transcript 3,GenBank
pseudogene
HTC
Mus musculus FALSE
0 day neonate head
54339cDNA,
Mm.441473
RIKEN Q9QZ73
full-length enriched
chr13 library,---clone:4832420G24--product:testis
GO:0000151
derivedubiquitintranscript
ligase--- complex
3, pseudogene,--full insert○ sequence.
NM_172589 Lhfpl2
lipoma HMGIC
NM_172589
fusion partner-like
RefSeq 2 Mus musculus FALSE
lipoma HMGIC
218454
fusion partner-like
Mm.3165532Q8BGA2(Lhfpl2), mRNA.
chr13
GO:0008150biological_process
GO:0016020membrane// GO:0016021//GO
integral// GO:0005575
componentmof membrane○// cellular_component
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17352884
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82.01708
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0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main
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2Down

2Down

w

w

NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr18
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_178005 Lrrtm2
leucine rich repeat
NM_178005
transmembrane
RefSeq neuronal
Mus musculus
2
leucine
TRUE rich repeat
107065transmembrane
Mm.39900 Q8BGA3
neuronal 2 (Lrrtm2),
chr18 mRNA.
GO:0002091negative// GO:0050808
regulation
GO:0005886//of
GO:0050808
receptor
plasma// GO:0016020
internalization
membrane// GO:0060291
GO:0042043// //GO:0016021// membrane
synapseneurexin////GO:0050808
GO:0042043
organization//
family// integral
GO:0030054○ proteincomponent// synapse
binding// GO:0045202
organization
of// membrane
neurexin//family
GO:0045// //long-ter
cell
prot
ju
ENSMUST00000097612
Gm10545 predicted gene
ENSMUST00000097612
10545 ENSEMBL ensembl:knownTRUE
chromosome:GRCm38:18:37008869:37020679:-1--Mm.474985 Q3UTM7 chr18gene:ENSMUSG00000073594
GO:0008150biological_process
gene_biotype:protein_coding
GO:0005575cellular_component
GO:0003674
transcript_biotype:protein_coding
molecular_function○
NM_001039485
Piezo2
piezo-type mechanosensitive
NM_001039485
RefSeqion channel
Muscomponent
musculus piezo-typeTRUE
2mechanosensitive
667742 Mm.158720
ion channel
Q8CD54component
chr18 2 (Piezo2),
GO:0006810
mRNA. transport// GO:0006811// ion
GO:0005886
transport// GO:0006812
plasma////cation
GO:0016020
membrane//transport
GO:0006812
GO:0005261// ////
GO:0016021
cationmembranecation////GO:0034220
transport
GO:0008381
channel// integral○// ionactivity////transmembrane
GO:0042391
component
GO:0008381// mechanically-gatedof //membranetransport
GO:0009612//
ionregulachan// G
NM_001164504
Rnf165ring finger protein
NM_001164504
165 RefSeq
Mus musculus ring
TRUE
finger protein
225743165 Mm.23293(Rnf165), mRNA.
E9QAU8chr18
GO:0000209protein// GO:0007409
polyubiquitination
GO:0005634// GO:0008045
nucleus////axonogenesis
GO:0043234// protein
GO:0010259
GO:0004842//complex
motorubiquitin-protein//neuron//GO:0030163
GO:0005515
axon○guidance
transferase////GO:0030513
GO:0008270// multicellular
activity////GO:0035136
GO:0046872// proteinorganismal
binding//ag
G
NM_009551 Zfand5
zinc finger, AN1-type
NM_009551
domainRefSeq5
Mus musculus zinc
TRUE
finger, AN1-type
22682 domain
Mm.292405
5 (Zfand5),
O88878mRNA.
chr19
GO:0001701in//utero
GO:0001944
embryonic
GO:0005737//development
GO:0003016
cytoplasm////vasculature
GO:0010761
GO:0003677
development
DNA////GO:0048008
GO:0008270
binding//○
respiratory// zinc////GO:0048705
GO:0046872
ion systembinding process// metal
GO:0048745//
ionfibroblastbinding// Gm
NM_177360 Dmrt3
doublesex and
NM_177360
mab-3 related
RefSeqtranscription
Mus factor
musculus
3 doublesex
TRUE
and240590
mab-3 related
Mm.62785transcription
Q80WT2
factorchr19
3 (Dmrt3), mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005634// regulation// nucleus
GO:0007548
GO:0003677
of transcription,
DNA////GO:0007628
GO:0003700
binding
DNA-templated○// sequence-specific////GO:0019226
GO:0043565// multicellular////DNA
GO:0021521
GO:0046872
organismal
binding trans
////G
de
G
NM_001163471
Hectd2
HECT domain
NM_001163471
containingRefSeq
2
Mus musculus HECTTRUE domain226098
containing
Mm.61107
2 (Hectd2),
Q8CDU6transcript chr19
variant 1, mRNA.
GO:0042787protein// GO:0016567
ubiquitination
GO:0005634// GO:0042787
involved
nucleus// GO:0005737
in ubiquitin-dependent// cytoplasm
GO:0004842// GO:0005634// nucleus
ubiquitin-protein//protein
GO:0008766////catabolic
cytoplasm
GO:0005737○ transferase// process
GO:0016874
activity// protein// GO:0018169// ubiquitination
UDP-N-acetylm// G/
NM_001142918
Tcf7l2transcription NM_001142918
factor 7 like 2,
RefSeqT cell specific,
Mus musculus
HMG box transcription
TRUE
factor21416
7 likeMm.139815
2, T cell specific,
Q924A0HMGchr19
box (Tcf7l2),GO:0000122
transcript variant
negative// GO:0000122
1, mRNA.
regulation
GO:0000790//ofGO:0001568
transcription
nuclear// GO:0005634
chromatin//from
GO:0005977
GO:0000978
RNA////GO:0005634
polymerase
nucleusRNA////GO:0006006
GO:0000978//polymerase
nucleusII //promoter
GO:0005654○ ////II//nucleoplasm
GO:0006351//
core
GO:0001103
negative
promoter// GO:0005667
regulation////proximaltranscription//GO:0006355
GO:0003677
of//regiontranscripti
GO:0005
factor//seq//GG
NM_010132 Emx2
empty spiracles
NM_010132
homeobox
RefSeq2
Mus musculus empty
TRUE spiracles13797
homeobox
Mm.245394
2 (Emx2),
Q04744
mRNA. chr19
GO:0006355regulation// GO:0007275
of GO:0005634
transcription,// GO:0007420
nucleus
DNA-templated// GO:0009952
GO:0000976// multicellulartranscription////GO:0009952
GO:0003677
organismal○
regulatory////GO:0010468
development
GO:0003700
region sequence-specific////GO:0021542
brain
GO:0043565
developmen
DNA// G
NM_178421 Nanos1
nanos homolog
NM_178421
1 (Drosophila)
RefSeq
Mus musculus nanos
TRUE homolog
332397
1 (Drosophila)
Mm.186390(Nanos1),
Q80WY3
mRNA.chr19
GO:0006417regulation// GO:0010631
of GO:0005737
translation// GO:0016477//cytoplasm
epithelial// GO:0048471// cell
GO:0010631//GO:0003723
perinuclear
migration// GO:0005737
RNA
region// //cell
GO:0010631
GO:0008270
binding
migrationof //cytoplasm
GO:0005737○// zinc////GO:0016477
epithelial
GO:0046872
ion// cytoplasm
binding// GO:0048471
cell migration////metal
GO:0016477
cytoplasm
GO:0003674
ion////GO:0048
bindingepithelia// //per//GG
NM_001166414
Rfx3
regulatory factor
NM_001166414
X, 3 (influences
RefSeq HLA Mus
classmusculus
II expression)
regulatory
TRUE
factor19726
X, 3 (influences
Mm.313321
HLA
P48381class II expression)
chr19(Rfx3),
GO:0006351
transcripttranscription,//variant
GO:0006355
2, mRNA.
GO:0000790
DNA-templated// GO:0007275
nuclear// GO:0000790// regulation
chromatin// GO:0007368
GO:0003677
of////GO:0005634
transcription,
nuclearDNA////GO:0030154
GO:0003700
chromatin
binding
DNA-templated// GO:0005667○////sequence-specific//nucleus//GO:0031018
GO:0005515//////multicellular
GO:0000790
transcription////DNA
GO:0042384
GO:0044212
organismal
bindingfactor comp
trans
////G
de
G
NM_172471 Itih5inter-alpha (globulin)
NM_172471
inhibitor
RefSeqH5
Mus musculus inter-alphaTRUE(globulin)
209378inhibitor
Mm.313876
H5 (Itih5),
Q8BJD1
mRNA.chr2
GO:0010466negative// GO:0030212
regulation
GO:0005576//of
GO:0008150
peptidase
extracellular// GO:0005575
activity// GO:0010951
GO:0004867
region// hyaluronan// cellular_component
serine-type// GO:0030414
metabolicendopeptidase○process// GO:0003674// biological_process
inhibitor activity ////peptidas
negativ
NM_011923 Angptl2
angiopoietin-like
NM_011923
2
RefSeq
Mus musculus angiopoietin-like
TRUE
26360
2 (Angptl2),
Mm.208919
mRNA.
Q9R045chr2----GO:0005576extracellular// GO:0070062--region // extracellular--vesicular○exosomeENSMUST00000124210
A430018G15Rik
RIKEN cDNAENSMUST00000124210
A430018G15ENSEMBLgene
havana:known chromosome:GRCm38:2:52425012:52431893:1
TRUE----Q8R0S4
chr2
gene:ENSMUSG00000085315----gene_biotype:processed_transcript------- transcript_biotype:processed_transcript--○
NM_053263 Hnrnpa3
heterogeneous
NM_053263
nuclear ribonucleoprotein
RefSeqMusA3
musculus heterogeneous
TRUE
229279nuclearMm.316306
ribonucleoprotein
Q8BG05// Mm.331491
A3 (Hnrnpa3),
chr2// Mm.379375
transcript
GO:0006397
variant mRNAc,//mRNA.
GO:0008380
processing
GO:0005634// //GO:0051028
RNA
nucleus//splicing
GO:0005681// //spliceosomal
GO:0055085
GO:0000166
mRNA// GO:0005737
transport
complex
nucleotide// GO:0003676// transmembrane// binding
cytoplasm
GO:0019012○ // //GO:0003723
nucleic//transportvirion// GO:0019013
acid// viralbinding// GO:0003729
nucleocapsid////GO:0030
RNA bin// /G
NM_172666 Agps
alkylglycerone
NM_172666
phosphateRefSeq
synthase Mus musculus alkylglycerone
TRUE
228061
phosphate
Mm.31227
synthase Q8C0I1(Agps), mRNA.
chr2
GO:0006629lipid// GO:0008610
metabolic
GO:0005730
process// GO:0055114//nucleolus
lipid// GO:0005739
biosynthetic// //GO:0008610
GO:0003824
mitochondrion//processGO:0005739
catalytic//////GO:0008611//GO:0008609
oxidation-reduction
mitochondrion
activity// GO:0005777○ //////GO:0008611
alkylglycerone-phosphate
GO:0008762// peroxisome
process// GO:0005778// //lipid//GO:0016491
peroxisomal
biosynthetic// GO:0043
synthaseme//pG
ENSMUST00000028398
Ube2e3ubiquitin-conjugating
ENSMUST00000028398
enzymeENSEMBLE2E 3 ensembl_havana_transcript:known
TRUE
22193chromosome:GRCm38:2:78869047:78921293:1
Mm.1485 // P52483
Mm.396925 chr2// Mm.426742
GO:0040008
gene:ENSMUSG00000027011
regulation// GO:0070534
of GO:0005634
growth// GO:0070936// protein
nucleus//gene_biotype:protein_coding
GO:0005737
K63-linked// cytoplasm
GO:0070979
GO:0000166
ubiquitination// GO:0005634// nucleus
nucleotide////GO:0070534
GO:0004842//transcript_biotype:protein_coding
proteinbinding○ K48-linked////GO:0070936//GO:0005515
ubiquitin-protein
ubiquitination////GO:0070979
GO:0005524
transferase// protein//acti//K1
GG
NM_011393 Slc1a2
solute carrierNM_011393
family 1 (glial
RefSeqhigh affinityMus
glutamatemusculustransporter),soluteTRUE carrier
memberfamily20511
21 (glial
Mm.267547
high affinity
P43006glutamatechr2
transporter),
GO:0006810
member 2transport(Slc1a2),// GO:0006835//transcript
dicarboxylic
GO:0005886// GO:0007399
variant
acid
plasma//3,GO:0005887
transportmRNA.
membrane// GO:0007632
GO:0005313// nervous// //GO:0016020
integralsystemL-glutamate////GO:0009416
GO:0005313
component
development// GO:0016021○
transmembraneof////GO:0009611
plasma
GO:0005314// visual// membrane
GO:0030424
transporter
behavior////GO:0010259
GO:0015293////activity
membrane
response// GO:0030////L-g//to
GG
NM_009754 Bcl2l11
BCL2-like 11NM_009754(apoptosis facilitator)
RefSeq
Mus musculus BCL2-likeTRUE
11 (apoptosis
12125 Mm.141083
facilitator) (Bcl2l11),
O54918 transcript
chr2 variant
GO:0001701
3, mRNA. in//utero
GO:0001776
embryonic
GO:0005622//development
GO:0001776
intracellular// GO:0005737////leukocyte
GO:0001782
GO:0005515// cytoplasm// GO:0005739
homeostasis
protein//////GO:0001782
mitochondrion
GO:0008017
binding//// leukocyte
GO:0005739○ //////
microtubule//
GO:0001783
GO:0008017
mitochondrion
homeostasis// GO:0005739
binding// //GO:0001822//Bmitochondrioncell// microtubule//homeostas
GO:0005// G
NM_001291056
Snap25synaptosomal-associated
NM_001291056
RefSeqprotein 25 Mus musculus synaptosomal-associatedTRUE
20614 Mm.45953
protein 25P60879(Snap25), transcript
chr2
variant
GO:0007269
2, mRNA.
neurotransmitter// GO:0007616
GO:0005623
secretion// GO:0010975
cell//// GO:0005737
long-term// cytoplasm// GO:0016197
GO:0000149
memory// GO:0005737
cytoplasm//SNARE//regulation//GO:0030431
GO:0000149// binding
endosome// of
GO:0005768○neuron//////GO:0034765
SNARE
GO:0005249//projection
trans-Golgi// GO:0005802
bindingdevelopment//network//GO:0046887
GO:0005515// voltage-gated////GO:0005
cytosol// endos////GpG
NM_019806 Vapb
vesicle-associatedNM_019806
membrane
RefSeqprotein,Mus
associatedmusculus
proteinvesicle-associated
TRUE
B and C 56491
membrane
Mm.260456
protein,
Q9QY76
associatedchr2
protein B and
GO:0006874
C (Vapb),cellularmRNA.
// GO:0006986
calcium
GO:0005783
ion// homeostasis
GO:0006987
endoplasmic// GO:0005789////response
GO:0019048
GO:0005198
reticulum// GO:0005794
to unfolded//structural//endoplasmic//GO:0030968
GO:0019899
protein//molecule
GO:0016020○reticulum// //activation//GO:0045070
activity
GO:0042803
membrane// of
GO:0016021// signaling
enzyme////GO:0006874//GO:0046982
Golgi
binding
protein// GO:0005
apparatus
activity// prote////GG
NM_001290376
Camk1dcalcium/calmodulin-dependent
NM_001290376
RefSeqproteinMus
kinasemusculusID
calcium/calmodulin-dependent
TRUE
227541 Mm.191949
protein
Q8BW96kinase IDchr2(Camk1d), transcript
GO:0006468
variant
protein// GO:0006954
4, mRNA.
phosphorylation
GO:0005634// GO:0007399//nucleus
inflammatory// GO:0005737// cytoplasm
GO:0008152
GO:0000166
response// GO:0005634// nucleus
nucleotide//////nervous
GO:0010976
GO:0003824////nucleus
systembinding
GO:0005634○ ////development
GO:0016310//GO:0004672
catalytic
cytoplasm// GO:0005737
activity//////
metaboliccytoplasm
GO:0032793
GO:0004674// protein// GO:0005
processkinas////GG
NM_001290576
Pbx3
pre B cell leukemia
NM_001290576
homeobox
RefSeq3
Mus musculus pre
TRUE
B cell leukemia
18516
homeobox
Mm.239941
3 (Pbx3),
O35317transcript
chr2
variant b, GO:0002087
mRNA.
regulation// GO:0006351
of GO:0005634
respiratory// GO:0006355
gaseousnucleus// GO:0005667
exchange// transcription
GO:0007585
GO:0003677
by// GO:0005634
neurologicalfactorDNA////GO:0008344
GO:0003700
complexbindingsystem○////sequence-specificprocess
nucleus////GO:0021516
GO:0005515// transcription,////DNA
GO:0048666
GO:0043565
binding
DNA-templa
trans
// G
NM_001100591
Rc3h2
ring finger and
NM_001100591
CCCH-type
RefSeqzinc finger Mus
domains
musculus
2
ring
TRUE
finger and319817
CCCH-type
Mm.288785
zinc finger
P0C090domains 2chr2(Rc3h2), transcript
GO:0000209
variant
protein//1,
GO:0001782
mRNA.
polyubiquitination
GO:0005634// GO:0009791
nucleus////BGO:0005737
cell //homeostasis
cytoplasm
GO:0010468
GO:0003677// GO:0009986//// cell
post-embryonic
DNA////GO:0010608
surface
GO:0003723
binding// GO:0016020//○membrane// development
RNA////GO:0035264
GO:0003729
binding//// GO:0000932
cytoplasmic// regulation
mRNA////GO:0042098
GO:0004842
bindingmRNA//ofGO:0005
gene
proce
////ubiexp//GG
ENSMUST00000028087
Ppp6c
protein phosphatase
ENSMUST00000028087
6, catalytic
ENSEMBL
subunitensembl_havana_transcript:known
TRUE
67857chromosome:GRCm38:2:39194354:39226451:-1
Mm.389242 Q9CQR6// Mm.171389
chr2// Mm.392662
GO:0006470// Mm.398121
gene:ENSMUSG00000026753
protein// GO:0007049
dephosphorylation// Mm.475023
GO:0005737// GO:0006470
cytoplasm// gene_biotype:protein_coding
GO:0005829
cell cycle// GO:0006470//GO:0004721
cytosol// protein// GO:0005829// cytosol
dephosphorylation
phosphoprotein// GO:0004722//transcript_biotype:protein_coding
cytosol// GO:0005829○ phosphatase// GO:0016787
protein dephosphorylation
activity// GO:0046872// protein serine/// G
NM_001289521
Zeb2
zinc finger E-box
NM_001289521
binding RefSeq
homeobox 2 Mus musculus zinc
TRUE
finger E-box
24136
binding
Mm.440702
homeoboxQ9R0G7
2 (Zeb2), transcript
chr2
variant
GO:0001755
3, mRNA.neural// GO:0001756
crest cell
GO:0005634
migration// GO:0001843
nucleus// GO:0005634
somitogenesis// nucleus
GO:0006351
GO:0003676// //GO:0005730//neuralnucleolus
nucleic////GO:0006355
tube
GO:0003677
acid//closure//cytoplasm
GO:0005737○
binding// //transcription,
GO:0007417
GO:0003700// DNA binding
DNA-templated////GO:0021766
GO:0043565// sequence-spe//////reg
GG
NM_001037099
Cacnb4
calcium channel,
NM_001037099
voltage-dependent,
RefSeqbeta
Mus 4musculus
subunit calcium
TRUE channel,
12298
voltage-dependent,
Mm.330223 Q8R0S4
beta 4 subunit
chr2 (Cacnb4),
GO:0006810
transcript transportvariant// GO:0006811
1, mRNA.
// ion
GO:0005886
transport// GO:0006816
plasma////calcium
GO:0005891
membrane// ion
GO:0006816
GO:0005244
transport// //GO:0005891
voltage-gated//voltage-gated////calcium
GO:0006874
GO:0005245//ion
calcium
GO:0005891○transport
ion//channel//GO:0007214
channel
GO:0005245// //cellular
activity
GO:0045202
complex//calcium//GO:0007528
GO:0005262
voltage-gated// voltage-gated//ion
GO:0005
homeos//cal//GG
NM_001001182
Baz2b
bromodomain
NM_001001182
adjacent toRefSeq
zinc finger domain,
Mus musculus
2B
bromodomain
TRUE
407823
adjacentMm.228071
to zinc finger
A0PJF0domain, 2Bchr2(Baz2b), mRNA.
GO:0008150biological_process
GO:0005575cellular_component// GO:0005634
GO:0046872// nucleus
metal// GO:0003674
ion binding○ //// GO:0003677
molecular_function// GO:0008270// DNA bindin
NM_001025093
Atf2
activating transcription
NM_001025093
factor
RefSeq2
Mus musculus activating
TRUE
transcription
11909 Mm.209903
factor 2 (Atf2),
P16951transcript chr2
variant 1, mRNA.
GO:0003151outflow// GO:0006351
tract GO:0005634
morphogenesis// GO:0006355
nucleus// GO:0005634// transcription,// nucleus
GO:0006366
GO:0000980// DNA-templated
GO:0005737// cytoplasm
RNA////GO:0006970
GO:0001077
polymerase////mitochondrion
GO:0005739//○
regulation//II//GO:0006974
distal
GO:0001102
ofenhancer////transcription,
GO:0005741
mitochondrial////GO:0016573
sequence-specific
GO:0003676
DNA-template//outer
GO:0016memb////GG
NM_001111289
Caprin1cell cycle associated
NM_001111289
protein
RefSeq1
Mus musculus cell
TRUE
cycle associated53872protein
Mm.427589
1 (Caprin1),
Q60865transcript
chr2variant 2,GO:0017148
mRNA.
negative// GO:0030154
regulation
GO:0000932//of
GO:0050775
translation
cytoplasmic// GO:0005737////cell
GO:0061003
mRNA
GO:0003723
differentiation// processing
GO:0010494
RNA////GO:0017148
GO:0044822// binding
positive
body// GO:0010494○// regulation//cytoplasm
poly(A)////GO:0017148
GO:0003723
RNAof////dendrite
GO:0042995
cytoplasmic
binding//morphogenesis
GO:0003723// RNA
stress// GO:0000
binding
granul//NM_001145824
Hipk3
homeodomain
NM_001145824
interactingRefSeq
protein kinaseMus
3 musculus homeodomain
TRUE
15259
interacting
Mm.257925
protein kinase
Q9ERH73 (Hipk3),
chr2transcriptGO:0000122
variant 2, mRNA.
negative// GO:0006351
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0005634//fromnucleus
GO:0006468
GO:0000166
RNA// GO:0005737//
polymerase
cytoplasm
nucleotide////GO:0006468
GO:0003677
II////
promotercytoplasm
binding
GO:0005737○ ////GO:0006915//GO:0003714
DNA
transcription,// PML//binding
GO:0016605
body////DNA-templated
GO:0009299//GO:0004672
nucleustranscription// GO:0005// cytop
//cor
//G
//G
NM_138313 Bmf
BCL2 modifying
NM_138313
factor RefSeq
Mus musculus BCL2
TRUEmodifying
171543factor Mm.210125(Bmf), mRNA.
Q91ZE9chr2
GO:0006915apoptotic// GO:0032464
process
GO:0001669////GO:0043276
positive
acrosomal// GO:0005737
regulation// vesicle
GO:0090200
GO:0005515
of protein////GO:0015629
cytoplasm
homooligomerization
protein// GO:2001234//
binding//actin
GO:0016459○ cytoskeleton// GO:2001235// anoikis// GO:0016459// myosin// //positive
GO:0043276
complexregulation// GO:0001// //myGoNM_001081133
Kif16bkinesin familyNM_001081133
member 16B
RefSeq
Mus musculus kinesin
TRUE family member
16558 Mm.251934
16B (Kif16b),
B1AVY7
mRNA. chr2
GO:0001704formation// GO:0001919
of primary
GO:0005622// GO:0006810
germintracellular
layer// GO:0005623// //regulation
GO:0006895
GO:0000166// cell// //of
GO:0005737
cytoplasm
receptor
nucleotide////GO:0007018
GO:0003777
recycling// //endosome
binding
GO:0005768○ //////
transport
GO:0007173//GO:0005524
microtubule// early// GO:0005769//endosome
Golgi//motor//GO:0007492
to
GO:0005547
endosome
activity////cytoskeleto
GO:0005////tran
AT//GG
NM_177586 Eif5a2
eukaryotic translation
NM_177586
initiation
RefSeqfactor 5A2
Mus musculus eukaryotic
TRUE
translation
208691 initiation
Mm.193670
factorQ8BGY25A2 (Eif5a2),
chr3
mRNA. GO:0006412translation// GO:0006414//GO:0005634
translational// GO:0006452
nucleuselongation// GO:0005643// nuclear
GO:0006810
GO:0003723// translational//pore
GO:0005737//RNA//cytoplasm//frameshifting
GO:0008284
GO:0003746
binding// GO:0005783○////endoplasmictranslation//////transport
GO:0008612
GO:0043022// elongation
GO:0016020
reticulum// positive// GO:0015031
factorregulation// membrane// GO:0005
activity
of
// ce
G//
NM_027016 Sec62
SEC62 homolog
NM_027016(S. cerevisiae)
RefSeq
Mus musculus SEC62
TRUE homolog
69276(S. cerevisiae)
Mm.26017(Sec62),
Q8BU14mRNA.
chr3
GO:0006620posttranslational// GO:0006810
GO:0005622
protein// GO:0015031
targetingintracellular// GO:0005623
to// membrane
GO:0006620
GO:0008565// cell// //GO:0005783
endoplasmic// proteintransport////GO:0006620
GO:0003674
transporter//reticulum//GO:0016020
protein○activitytransport// membrane// //GO:0016021
molecular_function// posttranslational// integral// GO:0005
componeprote
NM_001098170
Pcdh10
protocadherinNM_001098170
10
RefSeq
Mus musculus protocadherin
TRUE
10
18526
(Pcdh10),
Mm.242644
transcript
E9PX28variant 1, chr3mRNA.
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007155
plasma//cell
GO:0005887
adhesionmembrane// GO:0007156
GO:0005509////cell//
GO:0016020
integraladhesion
calcium// GO:0005515
component//ion//homophilic
GO:0016021
binding○ of plasma//cellproteinadhesionmembranebinding // membrane
NM_177855 Med12l
mediator complex
NM_177855
subunitRefSeq
12-like
Mus musculus mediator
TRUE complex
329650subunitMm.240059
12-like (Med12l),
Q8BQM9mRNA.
chr3
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0006357
nucleus// GO:0016592// regulation// mediator
GO:0006366
GO:0001104
of transcription,complex
RNA////GO:0008150
GO:0008013
polymerase
DNA-templated○ II// transcription
GO:0008134// regulation
cofactorof transcription
activity // be
NM_178892 Tiparp
TCDD-inducible
NM_178892
poly(ADP-ribose)
RefSeq polymerase
Mus musculus TCDD-inducible
TRUE
99929
poly(ADP-ribose)
Mm.246398polymerase
Q8C1B2 (Tiparp),
chr3
mRNA.
GO:0001570vasculogenesis// GO:0001822
GO:0005634// //kidney
GO:0006471
nucleusdevelopment// GO:0005634// nucleus
GO:0006807
GO:0003950// protein ADP-ribosylation
NAD+////GO:0008209
GO:0003950
ADP-ribosyltransferase○ ////GO:0008210
nitrogen
GO:0016740
compoundactivity////GO:0008585
GO:0016757//metabolic
NAD+ ADP-r
proc////GGENSMUST00000119109
Etv3
ets variant 3 ENSMUST00000119109
ENSEMBL havana:known chromosome:GRCm38:3:87525407:87540156:1
TRUE
27049 Mm.219460 Q8R4Z4// Mm.446456
chr3
gene:ENSMUSG00000003382// Mm.457227
GO:0000122negative// GO:0006351
gene_biotype:protein_coding
regulation
GO:0005634//of
GO:0006355
transcription
nucleus// GO:0017053//fromtranscriptional
GO:0006357
transcript_biotype:protein_coding
GO:0000981
RNA polymerase
sequence-specific//repressor//GO:0006366
GO:0003677
II promoter
complex○ ////DNA
GO:0030154//GO:0003700
transcription,binding RNA////DNA-templated
GO:0006366
GO:0005515
polymerase //
II//G
tra
//G
NM_008231 Hdgf
hepatoma-derived
NM_008231
growthRefSeq
factorMus musculus hepatoma-derived
TRUE
15191
growthMm.292208
factor (Hdgf),
P51859mRNA. chr3
GO:0000122negative// GO:0006351
regulation
GO:0005615//of
GO:0006355
transcription
extracellular// GO:0005615//from
GO:0006366
GO:0000166
space
RNA
// //GO:0005634
polymerase
extracellular
nucleotide////GO:0009987
GO:0001106
II space//
promoterbinding
GO:0005634○ //////nucleus
GO:0034504//GO:0001222
RNAtranscription,//polymerase//
GO:0005737
nucleus////DNA-templated
GO:0045944
GO:0003677//II cytoplasm
transcription// GO:0017
////G
//G
NM_001029890
Mex3a
mex3 homolog
NM_001029890
A (C. elegans)
RefSeq
Mus musculus mex3
TRUEhomolog 72640
A (C. elegans)Mm.275154(Mex3a),G3UYU0mRNA. chr3
GO:0008150biological_process
GO:0005575cellular_component
GO:0044822poly(A)// GO:0046872
RNA○binding// GO:0003723// metal ion binding// GO:0008270// RNA bind
NM_001165948
Pogz
pogo transposable
NM_001165948
element
RefSeqwith ZNF domain
Mus musculus pogo
TRUEtransposable
229584element
Mm.274787
with ZNF
Q8BZH4domain (Pogz),
chr3 transcript
GO:0007049
variant 2, cellmRNA.
// GO:0007064
cycle // GO:0000790
mitotic// sister
GO:0051301
nuclearchromatid// GO:0005634
chromatin// GO:0051382
cohesion
GO:0003676////GO:0005694
nucleus// cell
nucleic////GO:0007064
division
GO:0003677// chromosome
acid// GO:0005737//○
binding
kinetochore////GO:0007064
GO:0046872//// DNA
cytoplasm
assembly// GO:0000790
binding// //GO:0051382//nuclear//mitotic
metal// GO:0000
chromation
sisterbind// Gch
NM_001037737
Arntaryl hydrocarbon
NM_001037737
receptorRefSeq
nuclear translocator
Mus musculus aryl
TRUEhydrocarbon
11863
receptor
Mm.250265
nuclear translocator
P53762 (Arnt),
chr3 transcript
GO:0001666
variant 1, response
mRNA.
// GO:0001666
to hypoxia
GO:0005634// GO:0001892// response
nucleus// GO:0005634
to//hypoxia
nucleus
GO:0006351
GO:0000989////GO:0005667//embryonictranscription
transcription////GO:0006355
GO:0003677
placenta//factor
GO:0005667○
factordevelopment
complex////GO:0007165
binding
GO:0003700////transcription
GO:0005737
transcription// transcription,////GO:0009636
GO:0003705
factorfactor// GO:0005
DNA-teactivity
compl////GG
NM_207205 Igsf3
immunoglobulin
NM_207205
superfamily,
RefSeqmemberMus
3 musculus immunoglobulin
TRUE
78908
superfamily,
Mm.489667
memberQ6ZQA63 (Igsf3), chr3mRNA.
GO:0032808lacrimal gland
GO:0016020
development
membrane// GO:0016021//GO:0003674
integral// GO:0005575
component
molecular_functionof membrane○// cellular_component
NM_181400 Wdr47
WD repeat domain
NM_181400
47 RefSeq
Mus musculus WD
TRUE
repeat domain
99512
47 Mm.285968(Wdr47), mRNA.
Q8CGF6chr3
GO:0007275multicellular// GO:0008150
GO:0005737
organismal development
cytoplasm// GO:0005856//GO:0003674//cytoskeleton
biological_process// GO:0005874
molecular_function// microtubule// GO:0005575○ // cellular_component
NM_020265 Dkk2
dickkopf homolog
NM_020265
2 (Xenopus
RefSeqlaevis) Mus musculus dickkopf
TRUE homolog
56811
2 (Xenopus
Mm.103593
laevis)Q9QYZ8(Dkk2), mRNA.
chr3
GO:0007275multicellular// GO:0016055
GO:0005576
organismal// GO:0030178
development
extracellular// GO:0005615// GO:0090090--region// Wnt// //GO:0005576
signaling
extracellular--// GO:0090263
pathway//
space
GO:0005615○// negative// extracellular
GO:0090090
regulation
region// GO:0090263
of Wnt// extracellularsignaling p
NM_019745 Pdcd10
programmedNM_019745
cell death 10RefSeq
Mus musculus programmed
TRUE
cell
56426
deathMm.316473
10 (Pdcd10),
Q8VE70mRNA. chr3
GO:0001525angiogenesis// GO:0006915
GO:0005737// apoptotic// GO:0008284
cytoplasm
process// GO:0005794////GO:0043066//positive
GO:0042803
Golgi//apparatus
GO:0005829
regulation
protein////GO:0043406
GO:0047485//
of cytosol
homodimerizationcell// GO:0005886
proliferation○ ////plasma//GO:0008284
GO:0005515////
membrane
activity
negative
GO:0016020//////GO:0008284
regulation
proteinGO:0042803// membrane// N-terminu
GO:0070of apop////G//G
NM_001162999
Fnip2
folliculin interacting
NM_001162999
protein
RefSeq2
Mus musculus folliculin
TRUE interacting
329679proteinMm.244005
2 (Fnip2),
Q80TD3
mRNA. chr3
GO:0000122negative// GO:0001932
regulation
GO:0005622//of
GO:0006468
transcription
intracellular// GO:0005634//from
GO:0006974
GO:0003674// nucleus
RNA// GO:0005737
polymerase//molecular_function//cytoplasm
GO:0008630
II //promoter
GO:0005737//○cytoplasm// GO:0033138// regulation// GO:0005815
microtubuleof//protein
GO:0000122
organizing
phosphoryla// GO:0005// ce
G
NM_173347 Prune
prune homolog
NM_173347(Drosophila)
RefSeq
Mus musculus prune
TRUEhomolog
229589(Drosophila)
Mm.14155(Prune),Q8BIW1
mRNA. chr3
GO:0008150biological_process// GO:0008152
GO:0005634// metabolic
nucleus// GO:0005737
process// cytoplasm
GO:0004427// GO:0030054// cellinorganic// junction
GO:0016462//diphosphatase
GO:0005737○// cytoplasm// GO:0016787
activity//// GO:0005925
focal //adhesion//pyrophosphatase
GO:0030145 // aG
NM_010432 Hipk1
homeodomain
NM_010432
interactingRefSeq
protein kinaseMus
1 musculus homeodomain
TRUE
15257
interacting
Mm.20827
protein kinase
O889041 (Hipk1),
chr3mRNA. GO:0000122negative// GO:0006351
regulation
GO:0005622//of
GO:0006355
transcription
intracellular// GO:0005634//from
GO:0006468
GO:0000166// nucleus
RNA// GO:0005634
polymerase//nucleotide//nucleus//GO:0007224
GO:0003677
II //promoter//binding
GO:0005737
cytoplasm○ ////GO:0008284//GO:0003714
DNA
transcription,// cytoplasm//binding
GO:0005737////DNA-templated
GO:0009952//GO:0004672//transcription
PML// GO:0016
body ////cor//G//nG
NM_010306 Gnai3
guanine nucleotide
NM_010306
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
314679
binding
Mm.271703
protein (GQ9DC51protein), alphachr3 inhibiting
GO:0006184
3 (Gnai3),GTP
mRNA.
// GO:0006906
catabolic
GO:0005737
process// GO:0007049//cytoplasm
vesicle// GO:0005737
fusion// GO:0007165//GO:0000166
cytoplasm// cell// GO:0005765
cycle//
nucleotide////
lysosomal
GO:0007186//GO:0003924
signal// binding
GO:0005794
transduction○
membrane////GO:0007188//GO:0003924
GTPase//////Golgi
G-protein
GO:0005813
activity
apparatus////GO:0007193
GO:0004871
coupled// GTPase// //GO:0005
receptor
centroso
activ////GG
NM_019550 Ptbp2
polypyrimidine
NM_019550
tract binding
RefSeqprotein 2 Mus musculus polypyrimidine
TRUE
56195
tract binding
Mm.29966
proteinQ91Z31
2 (Ptbp2), mRNA.
chr3
GO:0006376mRNA// GO:0006376
spliceGO:0005634
site selection// GO:0006397
nucleus////GO:0005681
mRNA// spliceosomal
GO:0008380
splice
GO:0000166
site selection
complex
nucleotide////GO:0033119
GO:0003676// mRNAbinding○ //processing//GO:2000177//GO:0003723
nucleic acid// RNA//binding//GO:0033119
GO:0003729
splicing// RNA// negatbin// G
NM_019586 Ube2j1
ubiquitin-conjugating
NM_019586
enzymeRefSeq
E2J 1 Mus musculus ubiquitin-conjugating
TRUE
56228 enzyme
Mm.259095
E2J 1Q9JJZ4(Ube2j1), mRNA.
chr4
GO:0016567protein// GO:0018279
ubiquitination
GO:0005783// GO:0030433// protein
endoplasmic// GO:0016020
N-linked// GO:0016567
GO:0000166
reticulum
glycosylation// GO:0016021//nucleotide//membrane//GO:0018279
via
GO:0004842
asparagine// binding
GO:0005575○// integral////GO:0018279//GO:0005524
ER-associatedubiquitin-protein
component// GO:0005789////of
GO:0030433
GO:0016874
ubiquitin-depende
membranetransferase////acti//ce
GG
XM_006537592
Cnr1
cannabinoid XM_006537592
receptor 1 (brain)
RefSeq
PREDICTED: Mus
TRUE
musculus cannabinoid
12801 Mm.7992
receptorP47746
1 (brain) (Cnr1),
chr4 transcript
GO:0002866
variant X2,positivemRNA.
// GO:0007165
regulation
GO:0005886//ofGO:0007186
acuteplasma//inflammatory
GO:0016020
membrane// GO:0007188
GO:0004871
response// //GO:0016021
membranesignalto////GO:0007568
antigenic
GO:0004930
transducer//// integral
GO:0043231
stimulus○ //activity//GO:0007611
component
GO:0004949// signal//// GO:0030424
G-proteintransductionof //membrane//GO:0007613
GO:0008144
coupled// GO:0030////G-prote
receptointrace////GG
NM_178756 E130309F12Rik
RIKEN cDNANM_178756
E130309F12
RefSeqgene
Mus musculus RIKENTRUE cDNA272031
E130309F12
Mm.299460
gene (E130309F12Rik),
Q8BFZ2chr4 mRNA. GO:0007399nervous// GO:0007399
system
GO:0016020
development// GO:0008152
membrane// GO:0016021// nervous//GO:0003824
integralsystem// GO:0005575
component
development
catalytic ofactivity
membrane○// metabolic// process
cellular_component
NM_139309 Fktn
fukutin
NM_139309 RefSeq
Mus musculus fukutin
TRUE (Fktn),246179
mRNA. Mm.247210 Q8R507
chr4
GO:0001764neuron// GO:0008285
migration
GO:0005634// GO:0046329
negativenucleus// GO:0005783
regulation// endoplasmic
GO:0060049
GO:0016740
of cell// GO:0005794
proliferation
reticulumtransferase////GO:0008152
GO:0043842//////negative
GO:0005794
activity
Golgi○ //apparatus
GO:0008285
regulation// Kdo//transferase
GO:0005801//ofGolgi
JNK// GO:0008285
apparatus
cascadeactivity// GO:0016////regu//cisGENSMUST00000107415
Zfp618zinc finger protein
ENSMUST00000107415
618 ENSEMBL ensembl_havana_transcript:known
TRUE
72701chromosome:GRCm38:4:62965573:63139708:1
Mm.26479 //Q80YY7
Mm.482416chr4
GO:0006351
gene:ENSMUSG00000028358
transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleusgene_biotype:protein_coding// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
transcript_biotype:protein_coding
acid
DNA-templated○
binding// GO:0046872// DNA// biological_processbinding // metal ion bind
NM_007664 Cdh2
cadherin 2 NM_007664 RefSeq
Mus musculus cadherin
TRUE 2 (Cdh2),
12558
mRNA.
Mm.257437 P15116
chr4
GO:0007155cell// GO:0007156
adhesionGO:0005886// homophilic// GO:0007157
plasma//cell
GO:0005911
adhesionmembrane// GO:0007416
GO:0005509////heterophilic//
GO:0005911
cell-cell
calcium////GO:0016337
GO:0005515
junctioncell-cellion// GO:0005912
binding○//adhesioncell-cell////GO:0016339
GO:0008013// proteinjunction////synapse
GO:0005913
binding//////GO:0016339
assembly
adherens
GO:0019901// beta-catenin// GO:0005
junction// single////GG
NM_172698 Efcab14
EF-hand calcium
NM_172698
bindingRefSeq
domain 14 Mus musculus EF-hand
TRUE calcium
230648binding
Mm.283565
domain 14
Q8BGQ6(Efcab14), chr4mRNA.
GO:0008150biological_process
GO:0005575cellular_component
GO:0046872metal// GO:0003674
ion binding○ //// GO:0005509
molecular_function // calcium ion
ENSMUST00000106283
Rims3
regulating synaptic
ENSMUST00000106283
membrane
ENSEMBL
exocytosis
havana:known
3
chromosome:GRCm38:4:120861777:120896579:1
TRUE
242662 Mm.192502 Q80U57// Mm.388896
chr4//gene:ENSMUSG00000032890
Mm.396765
GO:0006810// Mm.479706
transport// GO:0006836////
gene_biotype:protein_coding
Mm.489236
neurotransmitter
GO:0005623// GO:0006887
cell// GO:0030054
transport// cell// junction
GO:0017156
GO:0044325//transcript_biotype:protein_coding
exocytosis// //GO:0045202
synapseion////GO:0042391//channel
GO:0005515
calciumbinding○
ion-dependent// GO:2000300// protein
exocytosis
binding// GO:2000300// regulation o
NM_018774 Phc2
polyhomeotic-like
NM_018774
2 (Drosophila)
RefSeq
Mus musculus polyhomeotic-like
TRUE
54383
2 (Drosophila)
Mm.490300(Phc2),Q9QWH1transcript
chr4
variant 1, GO:0007275
mRNA.
multicellular// GO:0007283
GO:0000792
organismal development
heterochromatin// GO:0005634
GO:0003677// spermatogenesis//// nucleus
GO:0005634
DNA// //GO:0005515
nucleusbinding// GO:0031519○//// protein
PcG// GO:0008270
proteinbinding// GO:0031519
complex// zinc// GO:0046872//
ionPcG//binding
GO:0035
protein//
ENSMUST00000084241
Wasf2
WAS proteinENSMUST00000084241
family, member
ENSEMBL2
ensembl_havana_transcript:known
TRUE
242687chromosome:GRCm38:4:133130505:133199756:1
Mm.23566 //Q8BH43
Mm.416453chr4
GO:0001525
gene:ENSMUSG00000028868
angiogenesis// GO:0001667
GO:0001726// ameboidal// GO:0006897
ruffle//cell
GO:0005622
gene_biotype:protein_coding
migration// intracellular// GO:0006928
GO:0003779////endocytosis
GO:0005622// intracellular
actin////GO:0010592
GO:0005515
binding// cellular//transcript_biotype:protein_coding//GO:0005737○
cytoplasm// protein
component////GO:0016601
GO:0032403
binding// //early
GO:0005769
movement
endosome////protein//GO:0030032
GO:0005515// complex//positive//GO:0005
cytoskel
//reg
bin
G
ENSMUST00000105868
Stmn1
stathmin 1 ENSMUST00000105868
ENSEMBL havana:known chromosome:GRCm38:4:134469742:134473499:1
TRUE
16765 Mm.378957 P54227
chr4gene:ENSMUSG00000028832
GO:0007019microtubule// GO:0007052
gene_biotype:protein_coding
depolymerization
GO:0005622// GO:0007275
intracellular// GO:0005737// mitotic// GO:0007399
GO:0005515// transcript_biotype:protein_coding
cytoplasm
spindle// GO:0005829
organization
protein//////GO:0007409
cytosol
GO:0015631
binding// //GO:0005856//○
multicellularcytoskeleton//////
tubulinGO:0030154
GO:0015631
binding
organismal// //GO:0005874
microtubule////GO:0031110
tubulindevelopment////binding
GO:0016
membran// //G
NM_177733 E2f2
E2F transcription
NM_177733
factor 2RefSeq
Mus musculus E2F
TRUE
transcription
242705factorMm.307932
2 (E2f2), mRNA.
P56931
chr4
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007049
nucleus// GO:0005667// regulation// transcription
GO:0051726
GO:0001047
of// GO:0005634
transcription,
factorcore////GO:0072332
GO:0003677
promotercomplex
DNA-templated○binding// nucleus////GO:1990086
GO:0003700// DNA// cellbinding
cycle////GO:0006355
GO:0005515// //regulation
sequence-sp
of
// G
c
NR_030771 Gm13034 SWI/SNF related,
NR_030771
matrix RefSeq
associated, actin
Mus musculus
dependentpredicted
TRUE
regulator geneof chromatin,
62758513034 (Gm13034),
Mm.424988
subfamily a,B2RT32
non-coding
member 5RNA.
chr4
pseudogene --------GO:0003677DNA// GO:0005524
binding○// ATP binding
NM_001159344
Casz1
castor zinc finger
NM_001159344
1
RefSeq
Mus musculus castor
TRUE zinc finger
69743
1 (Casz1),
Mm.233879
transcript
Q9CWL2variant 1,chr4mRNA.
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005737// regulation// cytoplasm
GO:0008150
GO:0003677
of// GO:0043231
transcription,// intracellular
DNA// GO:0046872
binding
DNA-templated// GO:0005634
membrane-bounded○// metal ion////binding
multicellular
GO:0005737
organelleorganismal////GO:0043
nucleusde
NM_145711 Tox
thymocyte selection-associated
NM_145711 RefSeqhigh mobility
Mus musculus
group box
thymocyte
TRUE
selection-associated252838 Mm.435828
highQ66JW3
mobility groupchr4box (Tox),---mRNA. --GO:0005634nucleus
GO:0003677DNA binding○
NM_001177849
Asphaspartate-beta-hydroxylase
NM_001177849
RefSeq
Mus musculus aspartate-beta-hydroxylase
TRUE
65973 Mm.222206(Asph), Q8BSY0transcript variant
chr4 3, mRNA.
GO:0007389pattern// GO:0008285
specification
GO:0005737// GO:0010524
process
cytoplasm// GO:0005783// negative// GO:0018193//GO:0004597
endoplasmic
regulation// GO:0005886
peptide-aspartate//ofreticulum//GO:0031585
cell
GO:0005509
proliferation// GO:0016020//○plasma//beta-dioxygenase//GO:0031647
GO:0005515// positive
membrane// GO:0016021
regulation////GO:0032237
activity
membrane
GO:0016491
of//calcium
GO:0030// calcium////inte//G
ioG
NM_026893 Dcaf12
DDB1 and CUL4
NM_026893
associated
RefSeqfactor 12 Mus musculus DDB1
TRUE and CUL4
68970
associatedMm.28891
factor 12
Q8BGZ3(Dcaf12), chr4mRNA.
GO:0008150biological_process// GO:0016567
GO:0005737// protein
cytoplasm// GO:0005813
ubiquitination//GO:0003674
centrosome// GO:0005856
molecular_function// cytoskeleton// GO:0080008○ // Cul4-RING// GO:0005737
E3 ubiquitin// ligase
GO:0005
com
ENSMUST00000157313
Gm26049 predicted gene,
ENSMUST00000157313
26049 ENSEMBL ncrna:known chromosome:GRCm38:4:41312091:41312198:-1
TRUE----Q8BGZ3
chr4
gene:ENSMUSG00000087938----gene_biotype:snRNA----- transcript_biotype:snRNA----○
NM_172381 AI314180 expressed sequence
NM_172381
AI314180
RefSeq
Mus musculus expressed
TRUE
sequence
230249AI314180
Mm.234801(AI314180),
Q6PDI5 mRNA.
chr4
GO:0030433ER-associated
GO:0000502
ubiquitin-dependent
proteasome// GO:0005634
proteincomplex--- catabolic// GO:0005737// nucleus---process////cytoplasm
GO:0005768○// endosome// GO:0005769// early//endosome
GO:0005
NM_144904 Ptbp3
polypyrimidine
NM_144904
tract binding
RefSeqprotein 3 Mus musculus polypyrimidine
TRUE
230257
tract binding
Mm.331640
proteinQ8BHD73 (Ptbp3), transcript
chr4
variant
GO:0006397
1, mRNA.mRNA// GO:0008380
processing
GO:0005634// //GO:0030154
RNAnucleussplicing// //GO:0033119
GO:0000166
cell differentiation
nucleotide////GO:0043249
GO:0003676// negative
binding○ //regulation//GO:0045595//GO:0003723
nucleicofacidRNA//binding//GO:0033119
splicing
GO:0044822// RNA// erythro//binG
NM_172694 Megf9
multiple EGF-like-domains
NM_172694 RefSeq
9
Mus musculus multiple
TRUE EGF-like-domains
230316 Mm.251188
9 (Megf9),
Q8BH27
mRNA. chr4----GO:0016020membrane// GO:0016021//---integral component--of membrane○
ENSMUST00000106061
S100pbp
S100P binding
ENSMUST00000106061
protein ENSEMBL ensembl_havana_transcript:known
TRUE
74648chromosome:GRCm38:4:129148005:129189542:-1
Mm.172064 Q9D5K4// Mm.408391
chr4// Mm.488265
GO:0008150gene:ENSMUSG00000040928
biological_process
GO:0005634nucleus// GO:0005634
gene_biotype:protein_coding// nucleus
GO:0048306calcium-dependent// GO:0048306
transcript_biotype:protein_coding○
protein binding // calcium-depend
NM_175306 Phactr4
phosphataseNM_175306
and actin regulator
RefSeq4
Mus musculus phosphatase
TRUE
and100169actinMm.158361
regulator 4 (Phactr4),
Q501J7 transcript
chr4 variant
GO:0001755
1, mRNA. neural// GO:0001843
crest cell
GO:0005622
migration// GO:0007266
intracellular// GO:0005737
neural// tube
GO:0007275
GO:0003779// cytoplasm
closure// GO:0030027//actin//Rho////GO:0007399
lamellipodium
GO:0004864
binding
protein// GO:0042995○
signal// protein//////GO:0030036
transduction
GO:0008157
cellphosphataseprojection// GO:0030027////GO:0043085
multicellular//GO:0071862
inhibitor
lamellipodium
activity
organ////GG
NM_001080819
Arid1aAT rich interactive
NM_001080819
domainRefSeq
1A (SWI-like)Mus musculus AT
TRUE
rich interactive
93760
domainMm.22478
1A (SWI-like)A2BH40(Arid1a),chr4
mRNA. GO:0000122negative// GO:0001843
regulation
GO:0000790//ofGO:0003205
transcription
nuclear// GO:0000790
chromatin//from
GO:0003408
GO:0003677
RNA////GO:0005622
polymerase
nuclearDNA////GO:0006325
GO:0005515
chromatin
bindingII //promoter
GO:0005634○////protein//intracellular//GO:0006337//GO:0016922
neuralbinding// GO:0016514
tube
// //
nucleus//closureligand-dependent//GO:0006338
GO:0031491//// SWI/SNF
cardiac
GO:0016////G
chnG
NM_001163794
Pdik1lPDLIM1 interacting
NM_001163794
kinaseRefSeq
1 likeMus musculus PDLIM1
TRUE interacting
230809kinaseMm.22778
1 like (Pdik1l),
Q8QZR7transcript
chr4variant 2,GO:0006468
mRNA.
protein// GO:0016310
phosphorylation
GO:0005634//nucleus
phosphorylation// GO:0005575// cellular_component
GO:0000166nucleotide// GO:0004672
binding○ // //GO:0004674
protein kinase// activity
GO:0005524// protein// G
NM_001081557
Camta1
calmodulin binding
NM_001081557
transcription
RefSeqactivator
Mus1musculus calmodulin
TRUE
binding
100072transcription
Mm.318846
activator
A2A8911 (Camta1),
chr4 transcript
GO:0006351
variant 1,transcription,mRNA.
// GO:0006355
GO:0005634
DNA-templated// GO:0008150
nucleus// GO:0005737// regulation// cytoplasm
GO:0003677
of transcription,
DNA// GO:0003674
binding
DNA-templated○// molecular_function// biological_process
NM_001099299
Ajap1
adherens junction
NM_001099299
associated
RefSeqprotein 1Mus musculus adherens
TRUE
junction
230959associatedMm.318874
proteinA2ALI51 (Ajap1), mRNA.
chr4
GO:0007155cell// GO:0008150
adhesionGO:0005886// biological_process
plasma// GO:0016020
membrane
GO:0003674// //GO:0016021
membranemolecular_function//// integral
GO:0030054○
component// GO:0005575
of membrane// GO:0005// cell ju
NM_001170745
Magi2
membrane associated
NM_001170745
guanylate
RefSeq kinase,MusWWmusculus
and PDZ
membraneTRUEdomain containing
associated50791 2Mm.332231
guanylate kinase,
Q9WVQ1WW andchr5
PDZ domain
GO:0002092
containing
positive//
2 GO:0007165(Magi2),
regulation
GO:0005634
transcript//ofGO:0007399
receptorvariant
nucleus// GO:0005737
internalization
3, mRNA.
// cytoplasm
GO:0008285
GO:0004871// //GO:0005737
signal// cytoplasm
signal////GO:0010976
transduction
GO:0005515
transducer// //GO:0005768○
endosome//activity//nervous
GO:0016482
GO:0019902//////latesystem
GO:0005770
proteinendosome////development
GO:0030336
binding
GO:0030159//// GO:0005//plasma
phosph//////neGm
G
NM_153526 Insig1
insulin induced
NM_153526
gene 1 RefSeq
Mus musculus insulin
TRUE induced
231070gene 1Mm.30221(Insig1), mRNA.
Q8BGI3chr5
GO:0006629lipid// GO:0006641
metabolic
GO:0005783
process// GO:0006695//endoplasmic
triglyceride// GO:0005783// GO:0006991
GO:0005515
metabolicreticulum// GO:0016020
process//protein//endoplasmic
GO:0008202//bindingcholesterol// GO:0016021○reticulum// GO:0008203
biosynthetic////membrane
GO:0032937
process// GO:0010894// integral// response
GO:0005
com// G
NM_008453 Klf3
Kruppel-like factor
NM_008453
3 (basic)
RefSeq
Mus musculus Kruppel-likeTRUEfactor16599
3 (basic)
Mm.439720(Klf3), mRNA.
Q60980chr5
GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:1901653
nucleus// regulation
GO:0003676
of transcription,
nucleic// GO:0003677
acid
DNA-templated○
binding// GO:0046872// DNA// cellularbinding//response
GO:0003677// metalto
ion
peptidbind
NM_001190734
Dcun1d4
DCN1, defective
NM_001190734
in cullin RefSeq
neddylation 1,
Musdomainmusculus
containing
DCN1,
TRUE4 defective(S. cerevisiae)
100737in cullin
Mm.220312
neddylation
Q8CCA01, domain chr5
containing 4GO:0008150(S. cerevisiae)
biological_process(Dcun1d4),
GO:0005634
transcript variant
nucleus// GO:0005575
A,//mRNA.
cellular_component
GO:0003674molecular_function○
NM_001122733
Kit
kit oncogeneNM_001122733
RefSeq
Mus musculus kit
TRUEoncogene (Kit),
16590
transcript
Mm.247073
variantP05532
1, mRNA. chr5
GO:0000187activation// GO:0001541
of MAPK
GO:0001669// activity
GO:0002318
acrosomal////GO:0005615
ovarian// vesicle
GO:0002320
GO:0000166
follicle////development
GO:0005622
extracellular
nucleotide////GO:0002327
GO:0002020
space////myeloid
binding
GO:0005737○ ////intracellular//GO:0002371
progenitor//GO:0004672
protease// GO:0005886
cell//bindingcytoplasm//differentiation//GO:0002551
GO:0004713// protein// GO:0005// plasma//kinas//lym//GG
NM_177680 Yth
m
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17519967
17520815
17522848
17523081
17526130
17528714
17529713
17530930
17530955
17531734
17533416
17535208
17535241
17538018
17538395
17538658
17539828
17541343
17543840
17544102
17544939
17545078
17545618
17545629
17546834
17547616
17547837
17547846
17548283
17548518
17548946

77.80013
381.8084
205.7395
70.94463
339.0828
235.3805
331.4807
64.3563986.2798
28.70505
512.7594
1145.401
124.9131
16.33215
9.817351
24.19338
24.83115
21.40386
12.03887
56.45731
360.417195.12606
57.85563
13.29709
541.8898
769.09485.62926
92.70303
948.6991
1182.456
826.8755

63.36783
686.8726
257.2575
40.75385
396.8731
249.4519
529.5917
59.80752
842.2397
28.00312858.501
546.4041
151.5649
16.62154
10.32762
22.67239
25.36139
20.2030712.28752
66.44284
267.6529
93.64679
41.40395
15.85833
1081.035
810.2198
88.08841
94.7348
1613.575
1200.466
1431.395

1.2277544
0.5558649
0.7997415
1.740808
0.8543859
0.9435907
0.6259175
1.076057
1.1710203
1.0250661
0.5972729
2.0962526
0.8241559
0.9825895
0.9505918
1.0670856
0.9790926
1.059436
0.979764
0.8497125
1.346584
1.0157963
1.3973457
0.8384925
0.5012694
0.9492412
0.9720832
0.9785531
0.5879486
0.9849975
0.5776711

0.296022-0.847194-0.322394
0.7997571-0.22704-0.083767-0.675956
0.1057545
0.2277661
0.035717-0.743538
1.0678126-0.279011-0.025339-0.073102
0.0936759-0.030483
0.0832965-0.029494-0.234953
0.4293042
0.0226111
0.4826889-0.25413-0.996342-0.075153-0.040848-0.031278-0.766238-0.021808-0.791680 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main0 main2Up

NM_011627 Tpbg
trophoblast glycoprotein
NM_011627 RefSeq
Mus musculus trophoblast
TRUE
glycoprotein
21983 Mm.20864(Tpbg), transcript
Q9Z0L0variant
chr9
1, mRNA. ----GO:0005737cytoplasm// GO:0005783//--endoplasmic// GO:0016020---reticulum// GO:0016021//○membrane ////GO:0005886
integral component of me
NM_001100451
Msl2
male-specificNM_001100451
lethal 2 homolog
RefSeq(Drosophila)
Mus musculus male-specificTRUE
lethal77853
2 homolog
Mm.326206(Drosophila)
Q69ZF8// Mm.436586(Msl2),
chr9mRNA. GO:0043984histone// GO:0043984
H4-K16
GO:0072487
acetylation
MSL////GO:0072487
histonecomplex
GO:0008270
H4-K16// MSL// GO:0072487
acetylation
complexzinc// GO:0008766
ion// binding
MSL○complex////UDP-N-acetylmuramoylalanyl-D-gl
GO:0016874 // GO:0018169 // G
NM_001048146
Azi2
5-azacytidineNM_001048146
induced gene
RefSeq2
Mus musculus 5-azacytidine
TRUE
induced27215 gene
Mm.92705
2 (Azi2),
Q9QYP6transcript variant
chr9 2, mRNA.
GO:0000278mitotic// GO:0001816
cell cycle
GO:0005737// cytokine
GO:0007249
cytoplasm// production
GO:0005737// GO:0032607//GO:0005515
cytoplasm// I-kappaB// GO:0005739//
protein// mitochondrion
kinase/NF-kappaB
GO:0032609
binding// GO:0005886○ //// GO:0032635
plasmasignaling
membrane// interferon-alpha// GO:0032640 prod// G
NM_007397 Acvr2b
activin receptor
NM_007397
IIB
RefSeq
Mus musculus activin
TRUE receptor11481
IIB (Acvr2b),
Mm.390239
mRNA.
P27040chr9
GO:0001501skeletal// GO:0001501
system
GO:0005623
development// GO:0001702
cell// GO:0005737//// cytoplasm
skeletal// GO:0001822
GO:0000166
system// GO:0005886
plasmadevelopment
nucleotide////GO:0001822
membrane
GO:0004672// binding
GO:0016020//○gastrulation// //membrane//GO:0001946//GO:0004674
protein//with
GO:0016021
kinase// mouth
integral////GO:0001974
activity
GO:0004674
formingcomponent// GO:0043// second
protein////of
GG
NM_007619 Cbl
Casitas B-lineage
NM_007619
lymphoma
RefSeq
Mus musculus Casitas
TRUE B-lineage12402
lymphoma
Mm.266871(Cbl), P22682
mRNA.
chr9
GO:0007166cell// GO:0014068
surface receptor
GO:0005634// GO:0023051
signaling
nucleus// GO:0005737
pathway// cytoplasm
GO:0043066
GO:0001784// positive// GO:0005886// plasma
regulation
phosphotyrosine////GO:0006468
GO:0004842
membrane//ofGO:0016020○
phosphatidylinositol//
binding//GO:0014068//GO:0004871
membrane// ubiquitin-protein
GO:0016600
3-kinase//////GO:0016567
flotillin
GO:0005509//
signaling
complex
GO:0005transferas////G//G
NM_001253862
Tcf12
transcription NM_001253862
factor 12
RefSeq
Mus musculus transcription
TRUE
factor21406
12 (Tcf12),
Mm.171615
transcript
Q61286variant chr9
2, mRNA. GO:0006351transcription,// GO:0006355
GO:0005634
DNA-templated// GO:0007275
nucleus// GO:0005667// regulation// transcription
GO:0007399
GO:0003677
of// GO:0005634
transcription,
factorDNA////GO:0010628
GO:0003700
complexbinding
DNA-templated○////sequence-specificnucleus////GO:0030154
GO:0005515// multicellular////DNA
GO:0045666
GO:0035497
organismal
binding trans
////G
de
G
NM_001114977
U2surpU2 snRNP-associated
NM_001114977
SURP
RefSeqdomain Mus
containing
musculus U2
TRUE
snRNP-associated67958 Mm.292742
SURP domain
Q6NV83containingchr9(U2surp), transcript
GO:0006396
variant
RNA// 1,
GO:0008150
processing
mRNA.GO:0005634// biological_process
nucleus// GO:0005634// nucleus
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0044822// RNA bin
NM_001042779
Sema3bsema domain,
NM_001042779
immunoglobulin
RefSeqdomainMus(Ig),musculus
short basic
sema
TRUE
domain,domain,secreted,
20347
immunoglobulin(semaphorin)
Mm.4083domain
Q62177
3B (Ig), shortchr9
basic domain,
GO:0007275
secreted,multicellular(semaphorin)// GO:0007399
GO:0005576
organismal
3B//(Sema3b),
GO:0030154
development
extracellular// GO:0016020
transcript
GO:0004872
region// variant
nervous// membrane
1,systemmRNA.
receptordevelopment
activity○// cell differentiation
NM_008138 Gnai2
guanine nucleotide
NM_008138
binding
RefSeqprotein (G Mus
protein),musculusalpha guanine
inhibiting
TRUE nucleotide
214678
binding
Mm.196464
protein (GP08752protein), alphachr9 inhibiting
GO:0000186
2 (Gnai2),activationmRNA.
// GO:0001973
of MAPKK
GO:0005634// GO:0006184
activity
nucleus// GO:0005737// adenosine// cytoplasm
GO:0007049
GO:0000166
receptor// GO:0005813// centrosome
nucleotide//signaling//GO:0007165
GO:0001664//pathwaybinding
GO:0005829○// cytosol////GO:0007186////
GO:0003924
G-protein
GTP// heterotrimeric// catabolic
GO:0005834
coupled////GO:0007188
GO:0004871
process
G-proteinreceptor// GO:0005// cellbindcom////GcG
NM_016853 Stacsrc homologyNM_016853
three (SH3)RefSeq
and cysteineMusrichmusculus
domain src
TRUEhomology three
20840
(SH3)
Mm.1414and cysteine
P97306rich domainchr9(Stac), mRNA.
GO:0034605cellular// GO:0035556
response
GO:0005737
to heat cytoplasm////intracellular
GO:0005575//GO:0046872
cellular_component
signal transduction
metal// GO:0003674
ion binding○// molecular_function
NM_010028 Ddx3x
DEAD/H (Asp-Glu-Ala-Asp/His)
NM_010028 RefSeqbox polypeptide
Mus musculus
3, X-linked
DEAD/HTRUE (Asp-Glu-Ala-Asp/His)
13205 Mm.289662
boxQ62167
polypeptidechrX3, X-linked (Ddx3x),
GO:0002376
mRNA.
immune// GO:0006200
system
GO:0005634
process// GO:0006351
nucleus////ATPGO:0005737
catabolic// cytoplasm
GO:0006355
GO:0000166
process// GO:0005739// mitochondrion
nucleotide//////GO:0006417
transcription,
GO:0003676// binding
GO:0005741○ // //
DNA-templated
mitochondrial//GO:0006915//GO:0003677
nucleic// GO:0005852
acid
outer
////binding//GO:0007059
regulation
GO:0003723
membrane////GO:0010
DNAof trans////bin//eu
GG
NM_001290424
Fmr1
fragile X mental
NM_001290424
retardation
RefSeqsyndrome Mus
1 musculus fragile
TRUE X mental14265
retardation
Mm.3451
syndrome
P35922
1 (Fmr1), chrXtranscript variant
GO:0006810
2, mRNA.
transport// GO:0007417// central
GO:0005634// nervous
GO:0045947
nucleus//system
GO:0005737// development
cytoplasm
GO:0051028
GO:0003723// GO:0005844// polysome//RNAnegative// GO:0005515
binding////regulation
GO:0005845
mRNA○// protein// cap
GO:0008017
of translationalbindingbinding// GO:0005874
complex// microtubule// initiation
GO:0044822// microtubu
GO:0010//bindingmRNA// G
ENSMUST00000096420
Styx
serine/threonine/tyrosine
ENSMUST00000096420
interaction
ENSEMBLprotein
havana:known chromosome:GRCm38:X:68821093:68825318:1
TRUE
56291 Mm.202561 Q60969// Mm.434636
chrX
gene:ENSMUSG00000071748
GO:0006470protein// GO:0007283
dephosphorylation
gene_biotype:protein_coding
GO:0005737// GO:0016311
cytoplasm// GO:0005634
spermatogenesis// GO:0045204//transcript_biotype:protein_coding
GO:0004721
nucleus // dephosphorylation
phosphoprotein////GO:0070372
GO:0005515○ phosphatase//// GO:0008138
MAPK export
activityfrom// GO:0016787// nucleus
protein bindin// reg// G
NM_013724 Nrk
Nik related kinase
NM_013724 RefSeq
Mus musculus Nik
TRUE
related kinase
27206(Nrk),
Mm.482319
mRNA. Q9R0G8
chrX
GO:0006468protein// GO:0007256
phosphorylation
GO:0005737// GO:0007567//cytoplasm
activation// GO:0005737// GO:0008285
of//GO:0000166
cytoplasm
JNKK activity
nucleotide////GO:0016310//
GO:0004672
parturition
binding○ ////GO:0023014
negative//GO:0004672
proteinregulation
kinase////GO:0035556
activity
GO:0004674
of cell //proliferat
protein////GG
NM_001033795
Zcchc16
zinc finger, CCHC
NM_001033795
domainRefSeq
containing Mus
16 musculus zinc
TRUE
finger, CCHC
619287
domainMm.387961
containing
Q3URY016 (Zcchc16),
chrX mRNA. GO:0008150biological_process
GO:0005575cellular_component
GO:0003676nucleic// GO:0008270
acid ○
binding// GO:0046872// zinc ion binding// GO:0003674// metal ion b
NM_001271678
Wnk3
WNK lysine deficient
NM_001271678
protein
RefSeqkinase 3 Mus musculus WNK
TRUElysine deficient
279561 protein
Mm.441474
kinaseQ80XP93 (Wnk3), transcript
chrX
variant
GO:0006468
1, mRNA.
protein// GO:0010765
phosphorylation
GO:0005737// GO:0010800//cytoplasm
positive// GO:0005912//regulation
GO:0016310//GO:0000166
adherens// of
GO:0005923
sodiumjunction
nucleotide////GO:0032414
GO:0004672
ion// transport//
tightbinding
GO:0005737○junction////GO:0043066////GO:0004674
positive
protein// cytoplasm
kinaseregulation////GO:0046777
activity
GO:0005524
of peptidyl-thr// protein////GG
NM_019461 Usp27x
ubiquitin specific
NM_019461
peptidase
RefSeq27, X chromosome
Mus musculus ubiquitin
TRUE specific54651
peptidase
Mm.483107
27, X chromosome
Q8CEG8// Mm.491689(Usp27x),
chrX
mRNA.
GO:0006508proteolysis// GO:0006511//GO:0005575
ubiquitin-dependent
cellular_component
proteinGO:0008233
catabolicpeptidase
process// GO:0008234
activity○ //// GO:0016787
cysteine-type peptidase// GO:0036459
activity// G/
NM_001290708
Smarca1
SWI/SNF related,
NM_001290708
matrix RefSeq
associated, actin
Mus musculus
dependentSWI/SNF
TRUE
regulator of
related,chromatin,
93761
matrixMm.229151
subfamily
associated,
a,Q6PGB8
memberactin dependent
1 chrX regulator
GO:0000733
of chromatin,
DNA// GO:0006200
subfamily
strand renaturation
GO:0000790
a, member// GO:0006338
nuclear//1//ATP(Smarca1),
GO:0005634
catabolicchromatin// GO:0006351
GO:0000166
transcript
process////GO:0016589
nucleusvariant
nucleotide//////GO:0006355
chromatin
GO:0003676
// 2,
NURF
//mRNA.
binding
GO:0090537○remodelingcomplex////GO:0007420//GO:0003677
nucleic// //CERF// GO:0005634
transcription,
acidcomplex//binding//GO:0007420
GO:0003682
DNA-templa//////GO:0005
nucleus
DNA//bin//GG
NM_001077354
C77370expressed sequence
NM_001077354
C77370
RefSeq
Mus musculus expressed
TRUE
sequence
245555C77370
Mm.381907(C77370),
Q5DTT1
mRNA.chrX
GO:0000084mitotic// GO:0006287
S phase
GO:0005634////base-excision
GO:0006297
nucleus// GO:0043625
repair,// delta
GO:0007275
GO:0003887
gap-filling
DNA// GO:0005634
polymerase
DNA-directed////GO:0007346
nucleotide-excision
GO:0008408
complex// GO:0043625○DNA//////
GO:0007399
polymerase
GO:0003887
nucleusrepair, DNA// activity
delta////gap
GO:0043137
GO:0008408
DNA
filling// 3'-5'
polymerase//exonucmultic// G
ENSMUST00000150434
Brwd3
bromodomain
ENSMUST00000150434
and WD repeat
ENSEMBLdomainensembl_havana_transcript:novel
containing 3 TRUE
382236chromosome:GRCm38:X:108737016:108834348:-1
Mm.426127 A2AHJ4// Mm.100112
chrX// Mm.404226
GO:0007010// Mm.404234
gene:ENSMUSG00000063663
cytoskeleton// GO:0008360// Mm.413432
GO:0005575
organization// GO:0007010
cellular_component// regulation
gene_biotype:protein_coding// GO:0008360
GO:0005515
of cell shapeprotein//////
GO:0007010
GO:0003674
cytoskeletonbindingtranscript_biotype:protein_coding○ ////organization
molecular_function
GO:0008360// regulation// GO:0008150
of cell sha
NM_001077364
Tsc22d3
TSC22 domain
NM_001077364
family, member
RefSeq3
Mus musculus TSC22
TRUE domain14605
family, Mm.22216
member 3 (Tsc22d3),
Q9Z2S7 transcript
chrX variant
GO:0000122
1, mRNA.negative// GO:0006355
regulation
GO:0005634//of
GO:0006970
transcription
nucleus// GO:0005737//fromcytoplasm
GO:0048642
GO:0003700
RNA// GO:0005634
polymerase// nucleus
sequence-specific////GO:0070236
GO:0043426
II////
promotercytoplasm
GO:0005737○ // DNA
GO:0007589// regulation
binding transcriptionof transcription,
factorDNAac
NM_019496 Ammecr1 Alport syndrome,
NM_019496
mental RefSeq
retardation, midface
Mus musculus
hypoplasia
AlportTRUE
andsyndrome,
elliptocytosis
56068
mentalchromosomal
Mm.143724
retardation,
Q9JHT5regionmidfacegenehypoplasia
chrX
1
andGO:0008150
elliptocytosis
biological_process
chromosomal
GO:0005575
region gene
cellular_component
1 (Ammecr1),
GO:0003674
mRNA.molecular_function○
XM_006528794
Ptchd1
patched domain
XM_006528794
containing
RefSeq1
PREDICTED: Mus
TRUE
musculus211612
patchedMm.218811
domain containing
Q14B62
1 (Ptchd1),
chrX transcript
GO:0007224
variant X2,
smoothened//mRNA.
GO:0050890
GO:0005886
signaling// GO:0007224
pathwayplasma// GO:0016020//membranecognition// GO:0050890
GO:0008158//////
GO:0016021
smoothened
membranehedgehog// GO:0003674//
signaling//receptor
integral
GO:0005886○
pathway
component
activity ////molecular_function
cognitionof membrane // plasm
NM_011077 Phex
phosphate regulating
NM_011077
endopeptidase
RefSeqhomolog,
Mus musculus
X-linked
phosphate
TRUE
regulating
18675 endopeptidase
Mm.2529 P70669
homolog, X-linked
chrX (Phex),
GO:0006508
mRNA. proteolysis// GO:0019637//GO:0005783
organophosphate// GO:0030282
endoplasmic// GO:0005794
metabolic// GO:0031214
GO:0004222
reticulum
process// GO:0016020//metalloendopeptidase//Golgi////GO:0006508
bone
GO:0008233
apparatus
mineralization// GO:0016021○ // membrane
GO:0008237
activity// biomineral// GO:0048471////peptidase
integral// GO:0016787
tissuecomponent
activity
developme//// G
NM_012008 Ddx3y
DEAD (Asp-Glu-Ala-Asp)
NM_012008 RefSeq
box polypeptide
Mus 3,
musculus
Y-linkedDEAD
TRUE (Asp-Glu-Ala-Asp)
26900 Mm.302938
box polypeptide
Q620953, Y-linked
chrY (Ddx3y),
GO:0006200
mRNA. ATP// GO:0008152
catabolic
GO:0005634
process //nucleus
metabolic// GO:0005737// process
cytoplasm
GO:0000166nucleotide// GO:0003676
binding○ // //GO:0003723
nucleic acid binding// GO:0004386// RNA bin// G------X91866
GenBank M.musculus mRNA
TRUE
for H3.3A--- variant --histone.
P84244
chr11
GO:0006334nucleosome// GO:0007420
GO:0000786
assembly// GO:0009725// nucleosome
brain// GO:0005634
development
GO:0003677// nucleus// GO:0005654// response//DNA
nucleoplasm// GO:0046982
binding
to hormone// GO:0005694○////protein
chromosome
heterodimerization activity
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
ENSMUST00000183695
Gm21464 predicted gene,
ENSMUST00000183695
21464 ENSEMBL havana:known chromosome:GRCm38:14:69365102:69503236:-1
TRUE
100862085 Mm.291443 Q920G8// Mm.441111
chr14
gene:ENSMUSG00000093954
GO:0006810transport// GO:0006811
gene_biotype:protein_coding// ion
GO:0005739
transport// GO:0034755
mitochondrion////iron
GO:0005743
ion// transmembrane
GO:0048250
GO:0005381
transcript_biotype:nonsense_mediated_decay// mitochondrial// GO:0005743
iron// transport
GO:0055072
ioninnertransmembrane// GO:0005743//
membrane○mitochondrial//transporter//mitochondrial
GO:0016020
iron ion activity
transport
inner// GO:0016
membr// iron i
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr3
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDG
NM_001081019
Gm12657 predicted gene
NM_001081019
12657 RefSeq
Mus musculus predicted
TRUE
gene
66725012657 (Gm12657),
Mm.449778 P84244
mRNA.
chr6
------------○
NM_008211 H3f3b
H3 histone, family
NM_008211
3B
RefSeq
Mus musculus H3
TRUE
histone, family
15081
3B (H3f3b),
Mm.371563
mRNA.
P84244chr1
GO:0001649osteoblast// GO:0006997
differentiation
GO:0000228// GO:0042692
nuclear// //nucleus
GO:0000788
chromosome//organization
GO:0090230
GO:0000979// GO:0005634// //nuclear
RNA//muscle//GO:1902340
GO:0000980
polymerase
nucleosome
cell// GO:0005634○
differentiation//II//GO:0006334
core
GO:0031492// nucleus
promoter// //GO:0043234
regulation// //nucleus
sequence-specific//GO:0007420
GO:0003677
of //centromere//GO:0070
protein////GcDGSupplementary Table 6. Validated and predicted target genes for Mir221 and Mir222
RGS6
SUN2
ARID1AKHDRBS2 KLF3
GRM1
GBX2
PHEX
CDKN1B ARHGEF7 DDIT4CPNE8ANKIB1RREB1HNRNPA0 MAGI1CXCL12 ARF4
NIPAL4MLLT6FGF14PTCHD1 DDX3Y
ANKS1B
TCF12
BRWD1
TPBG
RPH3A
S100PBPVASH1
INSIG1CAPRIN2RFX7RALGAPA1 MEGF9ATP1B1ERBB4CMTM4FERMT2
LRP10
SEC62
ZFPM2
CNR1
POGZ
EMX2
SPPL3
SPRED2ZFP90
GABRA1 KIAA1370 NFYB
REV1
CD2AP
MEX3A
HDGF
HECTD2 ANGPTL2 TSC22D3 USP27X
PHF2
ZNF654
PELI1
KIT
MIDN
CDK19
CDKN1CPDGFA
MAPK10 VKORC1L1
VGLL4 DPP8FOSKIAA1267 PLEKHA6
ZEB2
TEAD1
PAIP1
CHSY1
TOX
MESDC1
CNOT2
ACVR2B FBXO28
TP53BP2 MIER3
NAA25
RNPS1
AJAP1
MARCKS MARK1
NAP1L5 C3orf70
MSL2
VAPB
CDH2
AAK1
SMARCA1ZFAND5 CASZ1
ASPH
CBFB
ADAM11NFAT5EFCAB14NRKNSMCE4A GPM6A
KIAA0368 ITGB8NDFIP1
PPP6C
IRX5
YWHAG
AGFG1
LPPR1
HOXA7
STX1B
RC3H2
DCUN1D1 EIF3J
HIPK1
PAK1
BAZ2B
ANKRD52 CAMK1D
CLVS2 FOXN2NFATC3SPATS2L TAOK1
TCF4
RFX3
LRRTM2 CD4ZCCHC16 CBL
FAM167A
EIF4E3UBE2E3ETV3DCUN1D4 IGDCC4
CTCF
PBX3
TRPS1
PDCD10AP3B2 GPBP1CREBZF C11orf87
C14orf147 THRBU2SURP
PPP3R1 UBN2
TLE3
HIPK2
SLITRK5
DGKE
DDX3X
RIMS3
ZNF385A
DNAJC14 TP53INP1 LHFPL2
SLC1A2
THSD7B
DCAF12 PRUNEZFP36L2 FRS2
PTBP2
RNF165MAGI2
ZNF652 ARNTPPP2R2A ESR1AMMECR1 C16orf52 PGAP1
DMRT3 UBE2J1ZMYM2SMARCA5 CAPRIN1
AGPS
BBC3
CCDC64 PCDHA9
BRWD3
GNAI2
FOXP1
OSBPL7 STMN1EML6PCDHAC2 NLK
VEZF1ZNF618PVRL1CABYRCACNB4 PCDHAC1 SEMA3B TCF7L2
SRSF2
DNAL1
MED12LPLEKHA2 PCDHA13 HNRNPA3 H3F3A
IKZF4
E2F2
HELQ
NRG1
PCDHA12 IPO7DKK2GALNTL4
TNRC6C SLC25A37
NTF3
PCDHA11 ANKHD1 IGF2BP2
MAP3K2
SOCS7
MYBL1
FAM38B PCDHA10 STYXDENND1B C16orf45
SNX29
SYBU
SCD5
PCDHA8
FMR1
RNF44
AP3M1
WASF2
FAM214A
MIA3PCDHA7SNCB
PKDCC
CEP350KCNA1KLC1RBM24 PCDHA6
RUNX2
ETS2
TIMP3
KIAA2022 PANK3
FNDC3A PCDHA5
METTL10 C17orf63
ATAD2BRIMBP2
ADAM22
NOVA1 PCDHA4
WDR37
FAT2
RANBP2RALA
SNAP29TMCC1 PCDHA3
LOC388630 SEC23IP
MON2
FKTN
MCMDC2BCL2L11 PCDHA2BEND4SLC4A4PHC2
MAP3K10 PHACTR4
WDR47 PCDHA1
ST8SIA1 TIPARP
CUX1
SNAP25 CAMTA1
EIF5A2 GNAI3
ROD1
NUFIP2
SOCS1
ITIH5
ASB4
HMBOX1 SHANK2KIAA0494 ARL6IP1
FOXP2
PI15
URI1
WNK3
SBK1
AZI2
ZADH2
NANOS1
PCDH10 ZBTB41
C18orf25 ATF7
RAB1A
IGSF3
RAB3GAP2 FNIP2
RAB18
MYLIP
PAIP2
ITGB3
SH3PXD2B DLG2
CPEB4
LIMS1
KIF16B RSBN1L
HOXC10 PDIK1LYTHDC1STAC
GUCY1A2
BMF
ETS1
ZNF629KSR1GAB1PDZRN4 ATF2
IRF2
AXIN2
QKI
ATXN1
C2CD2
SDC2
CHD8
PLCL2 NIPBL
LRFN2
SH3BP4
TBC1D22B HIPK3
ASB7

Supplementary Table 7. Expression of candidate target genes of miR-221-3p and miR-222-3p in Mir221/222flox/y and Mir221/222AdipoKO mice fed with stardard (STD) and high fat-high sucrose (HFHS) chow.
Expression value

Annotation
Gene Symbol

Ratio
HFHS AdipoKO STD AdipoKO / STD flox_y HFHS AdipoKO / HFHS flox_y

Keyword

STD flox/y

HFHS flox/y

STD AdipoKO

HFHS flox_y / STD flox_y

HFHS AdipoKO / STD AdipoKO

miR221/222 target geneIgf2bp2

118.6727

92.12485111.7554

233.6214

0.94171111

2.535921632

0.776293537

2.090470796

○

Foxp2

53.29913

25.9217246.43985

56.34540.871305967

2.173675204

0.486344149

1.213298493

○

Ddit4

187.1108201.7627

482.7296

383.8727

2.579913078

1.902594979

1.078306009

0.795212682○

Tiparp370.4981

370.9203

243.0674

629.3118

0.656055726

1.696622698

1.001139547

2.589042381○

Gm13034

89.3279

42.14671

66.8210271.24998

0.748041989

1.690522938

0.471820226

1.06628094○

Cdkn1c139.7296

64.02979

86.02513

99.08630.615654307

1.547503123

0.458240702

1.151829704○

Gm17275

38.15434

25.35535

28.33733

38.61103

0.742702665

1.522796175

0.664546943

1.362550036○

Ppp2r2a173.6408

103.3587

136.4849

156.1966

0.786018609

1.511209023

0.59524432

1.144424035○

Caprin2105.00984.21983

107.7583

127.1511

1.026181565

1.509752513

0.802024874

1.17996572○

Fos

250.5789

115.658

96.99457

173.6935

0.387081953

1.501785436

0.461563204

1.790754885

○

Uri1

666.848366.2552

624.7025

515.4158

0.936798941

1.407258655

0.549233409

0.825058008

○

Mark1

85.06554

51.96034

72.25445

73.05361

0.849397418

1.405949422

0.610827134

1.011060357

○

Casz1

67.4341

63.58655

83.56946

87.91584

1.239275975

1.382616921

0.942943555

1.052009191

○

Itgb8

54.55101

51.56115

53.44313

71.05316

0.979690935

1.378036758

0.945191482

1.329509705

○

Agfg1

594.9557

470.1974

450.3722

646.7574

0.756984428

1.375501864

0.790306572

1.436050893

○

Etv3

409.6244

143.7052

342.2083

197.4402

0.835419716

1.37392523

0.350821875

0.576959121

○

Tle3

812.1421

684.8116

767.2126

920.5015

0.944677785

1.344167505

0.843216477

1.199799769

○

Ddx3x

858.501

512.7594

664.2457

688.9457

0.773727346

1.343604232

0.597272921

1.037185036

○

Cpne8

216.8393

187.5397

240.7783

249.4114

1.110399729

1.329912547

0.864878737

1.035854975

○

Pvrl1

127.8629

150.1472

130.7448

199.2742

1.022538985

1.327192249

1.174282767

1.524146276○

Pdzrn420.39221

18.83454

22.2017124.96736

1.088734865

1.325615598

0.923614459

1.124569234

○

Ets2

528.1785

309.0158

364.8452

406.857

0.690761173

1.316621998

0.585059407

1.115149658○

Smarca1

20.2030721.40386

22.6035

28.04365

1.118815111

1.310214606

1.059436016

1.240677329○