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66,, 129-140, 2011.

2) Lockley SW and Foster RC: Sleep. A Very Short Instruction. Oxford
Univ Press, Oxford, 2012.

6.

, 97-146, 2015.

.

, 

3) Dawson D and Reid K: Fatigue, alcohol use and performance
impairment. Nature 388, 235, 1997.
4) Van Dongen HPA, Malslin G, Mullington JM et al.: The cumulative

working conditions, and occurrence of non-insulin dependent
diabetes mellitus in Japanese men. J Epidemiol Commun Health 53,359-363, 1999.

cost of additional wakefulness: dose-response effects on17) Kivimäki M, Jokela M, Nyberg ST, et al.: Long working hours andneurobehavioral functions and sleep physiology from chronic sleep

risk of coronary heart disease and stroke: a systematic review andrestriction and total sleep deprivation. Sleep 26, 117-126, 2003.

meta-analysis of published and unpublished data for 603838

5) Belenky G, Wesensten NJ, Thorne DR, et al.: Patterns of performance

individuals. Lancet 386, 1739-1748, 2015.

degradation and restoration during sleep restriction and subsequent18) Kivimäki M, Virtanen M, Kawachi I, et al.: Long working hours,

recovery: a sleep dose-response study. J Sleep Res 12, 1-12, 2003.

socioeconomic status, and the risk of incident type 2 diabetes: a meta-6) Ayas NT, White DP, Manson JE, et al.: A prospective study of sleep

analysis of published and unpublished data from 222120 individuals.

duration and coronary heart disease in women. Arch Intern Med 163,
205-209, 2003.

Lancet Diabetes Endocrinol 3, 27-34, 2015.
19) Heikkila K, Nyberg S, Madsen IEH, et al.: Long working hours and7) Westerlund H, Alexanderson K, Åkerstedt T, et al.: Work-related sleep

cancer risk: a multi-cohort study. Br J Cancer 114, 813-818, 2016.

disturbances and sickness absence in the Swedish working20) Kawachi I, Colditz GA, Stampfer MJ, et al.: Prospective study of shift

population, 1993-1999. Sleep 31, 1169-1177, 2008.
8) Chandola T, Ferrie JE, Perski A, et al.: The effect of short sleep

work and risk of coronary heart disease in women. Circulation 92,3178-3182, 1995.

duration on coronary heart disease risk is greatest among those with21) Fujino Y, Iso H, Tamakoshi A, et al.: A prospective cohort study ofsleep disturbance. A prospective study from the Whitehall shift work and risk of ischemic heart disease in Japanese male

Cohort. Sleep 33, 739-744, 2010.

workers. Am J Epidemiol 164, 128-135, 2006.

9) Watanabe M, Kikuchi H, Tanaka K, et al.: Association of short sleep22) Kubo T, Ozasa K, Mikami K, et al.: Prospective cohort study of risk

duration with weight gain and obesity at 1-year follow-up: a large-of prostate cancer among rotating-shift workers from the Japan

scale prospective study. Sleep 33, 161-167, 2010.

Collaborative Cohort Study. Am J Epidemiol 164, 549-555, 2006.

10) Hamazaki Y, Morikawa Y, Nakamura K, et al.: The effects of sleep23) Viswanathan AN, Hankinson SE, Schernhammer ES.: Night shift

duration on the incidence of cardiovascular events among middle-work and risk of endometrial cancer. Cancer Res 67, 10618-10622,

aged male workers in Japan. Scand J work Environ Health 37, 411-2007.

417, 2011.
11) Ribet C and Demiennic F: Age, working conditions, and sleep
disorders: a longitudinal analysis in the French Cohort E.S.T.E.V.
Sleep 22, 491-504, 1999.
12) Sekine M, Chandola T, Marikainen P et al.: Work and family
characteristics as determinants of socioeconomic and sex inequalities

24) Hansen AB, Stayner L, Hansen J, et al.: Night shift work andincidence of diabetes in the Danish Nurse Cohort. Occup Environ
Med 73, 262-268, 2016.
25) Travis RC, Balkwil A, Fensom GK, et al.: Night shift work and breast
cancer incidence: three prospective studies and meta-analysis ofpublished studies. J Natl Cancer Inst 108, djw169, 2016.

in sleep: the Japanese Civil Servants Study. Sleep 29, 206-216, 2006.

26) Behrens T, Rabstein S, Wichert K, et al.: Shift work and incidence of13) Basner M, Fomberstein KM, Razavi FM, et al.: American Time Use

prostate cancer: a 10-year follow-up of German population-based

Survey: Sleep time and its relationship to waking activities. Sleep 30,1085-1095, 2007.
14) Virtanen M, Ferrie JE, Gimeno D, et al.: Long working hours andsleep disturbances: The Whitehall  Prospective Cohort Study.
Sleep 32, 737-745, 2009.
15) Nakashima M, Morikawa Y, Sakurai M et al.: Association between
long working hours and sleep problems in white-collar workers. JSleep Res 20, 110-116, 2011.
16) Kawakami N, Araki S, Takatsuka N, et al.: Overtime, psychosocial

cohort study. Scand J Work Environ Health 43, 560-568, 2017.