The TM900v2: A novel device for 3D measurementsof xenografts in mice

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The TM900v2: A novel device for 3D measurementsof xenografts in mice

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The TM900v2: A novel device for 3D measurementsof xenografts in mice
Rational:
Measurement of tumor sizes is important in preclinicalanimal studies, when assessing responses to cancer
treatments. Sequential measurements of tumor volume
with a non-invasive method are essential. The current
standard technique for volume determination of
subcutaneously xenografted tumors is measuring thelength and width of the tumor with a caliper. However,caliper measurements are prone to error due to e.g.
variability and compressibility of the tumor. An
alternative for these measurements is the TM900v2, a
direct 3D measurement method.

The TM900v2 is an innovative, non-invasive accurate
and easy to use handheld device for direct 3D
measuring tumor volume in subcutaneous mouse
xenografts in vivo.

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The TM900v2: A novel device for 3D measurementsof xenografts in micePrinciple:Mice are injected in the flank(s) with tumor cells. The tumor volume is measured over time by positioning thenozzle of the device over the tumor and pressing the button. The TM900v2 acquires the 3D images of thetopography of the tumor based on stereo vision; a structured light pattern is projected of the surface. The
deformation of the pattern is used to calculate the topography and subsequently, the volume of the tumors.

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The TM900v2: A novel device for 3D measurementsof xenografts in mice
TM900: A complete platform
The TM900v2 is a complete platform;
besides the handheld device, the TM900v2
comes with a touch screen laptop PC, ameasurement and a management
software. The measurement software
makes the image acquisition and allows
visualizing the tumor topography and theanalyzed surface. Important tumor
features such as volume, height, width anddepth are automatically calculated.
Previous measurements of the animal are
shown on the screen to allow
instantaneous follow-up of the tumor
volume over time. The software interface
also allows coupling other hardware suchas balances, facilitating complementarymeasurements. An export function isforeseen to export the data to themanagement software for further analysis.

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The TM900v2: A novel device for 3D measurementsof xenografts in mice
The management software allows for a complete data management of your experiment data. You can define
experiments, assign animals to groups (randomization), visualize the tumors and make plots of data. Export to e.g.
Excel is foreseen.

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The TM900v2: A novel device for 3D measurementsof xenografts in mice
The management software allows for a complete data management of your experiment data. You can define
experiments, assign animals to groups (randomization), visualize the tumors and make plots of data. Export to e.g.
Excel is foreseen.

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The TM900v2: A novel device for 3D measurementsof xenografts in mice

Why the TM900:-Visualization in 3D of the tumor topography. This allows for visual inspection of the tumor shape anmorphology over time and flagging of the necrotic or inflamed tumors.
Data integrity and traceability. The software allows for storage, analysis, visualization and management of data,
which is essential for robust data follow-up and QA-requirements.
Validation. High resolution 3D images are acquired, allowing precise volume estimations and validation of themeasured surface?. Especially oddly shaped or thin tumors benefit from the TM900v2 volume estimations.

Specifications:-Measurement range (X – Y)
Maximum tumor size (LxWxH)
Tumor size range-Accuracy per measurement 3D point:
Cameras:Projector:-

Camera/projector working distance
3D algorithm calculation:

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25mm-25mm (optional 30mm-30mm)
20mmx20mmx20mm (optional 25x25x20)
tumors detectable < 10mm3 up to maximum allowed.
(for small tumors, expression from under the skin required)<0.3mm1920x1080 pixels
300x300 pixels, 532nm (green for optimal contrast on
nude, black and white mice)
50mm<2sec (depending on processor used)

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The TM900v2: A novel device for 3D measurementsof xenografts in mice

Recommended PC specifications:• Intel Core i5, preferably i7 or better, min speed 2.6Ghz• 8GB of RAM and 256MB of available disk space for program installation• 200 MB disk space for program installation and sufficient space for experiment data (512 GBSSD recommended)• Min 2 USB ports for the TM900v2 and USB flash drive, optionally extra ports for optional weightbalance.
• Operation systems Windows 10 or 11 pro preferably Pro.
• screen resolution 1920x1080 or better, preferably touch screen.

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Contact

Contact us at:by e-mail: erikbuelens@budetec.behttps://budetec.be/contact/
https://tumorvolume.com/contact/

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