5(2), 132-142, 2013

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A study of medications for patients with epilepsy in Tottori Medical Center andregional medical liaison for medical care of such patients in the eastern part ofTottori Prefecture
Jun Saito1)*, Kotaro Shimoda1), Kazuhiko Inoue1), Yoshihiro Konishi1), Hiroshi Takahashi1),
Taizo Kaneto1), Mitsuru Doi1), Emi Fusayasu1) and Akane Doi1)
1) Department of Neurology, NHO Tottori Medical Center*Correspondence: saito-jun@tottori-iryo.hosp.go.jp

2012

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5(2),

132-142, 2013

Abstract
We investigated 67 outpatients with epilepsy who visited the outpatient clinic of neurology at Tottori
Medical Center (TMC) in July 2012. Twenty-one patients were female, and the mean age was 49.6, 24.2 and38.9 years old at the time of this investigation, the onset of epileptic seizures, and the first visit to TMC,respectively. Forty-two patients were referred from other hospitals in the eastern part of Tottori Prefecture;on the other hand, only 5 were from outpatient clinics. Eight, 25, 23, and only 3 patients suffered from
simple partial seizures, complex partial seizures, secondarily generalized seizures, and generalized seizures,respectively. The number of prescribed anti-epileptic drugs (AEDs) was smaller in 2012 than in 1992: the1percentage of patients treated with one or two AEDs was higher in 2012 than in 1992; however,approximately one-third of the patients were still treated with three or more AEDs at the time of thisinvestigation. The number of the patients treated with first-line AEDs, including carbamazepine (CBZ) andvalproate (VPA), has gradually increased over the past 20 years, and new AEDs have been increasing rapidly
since 2007. The administered dosage of classical AEDs, including phenytoin (PHT), phenobarbital (PB),
primidone (PRM), VPA, CBZ, zonisamide (ZNS), or others has decreased over the past 20 years. Regarding
the recent control of seizures, one patient had repeated statuses epilepticus, and 9, 8, 10 and 6 patients
experienced seizures weekly, monthly, one or more seizures over 6 months, and less than one seizure over 6months, respectively; however, 32 patients had had no seizures for the previous two years. Therefore, 18
patients suffered from so-called intractable epilepsies. Nineteen patients were classified into group 5 or 6,
according to the Comprehensive Classification of Epilepsy proposed by Yagi, and only one quarter ofpatients were employed. In conclusion, we should enlighten residents and medical staff in this area on theimportance of regional medical liaison, and fulfill the mission of TMC for medical service to patients
suffering from epilepsy. Tottori J. Clin. Res. 5(2), 132-142, 2013,

Key words:,,; epilepsy, regional medical liaison,anti-epileptic drugs (AEDs), seizure control,30.

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