Launch the Future

NEWS RELEASENews Release Dated October 18, 2022
Company: Japan System Techniques Co., Ltd.
Representative: Takeaki Hirabayashi, President and CEO
Stock code: 4323, Tokyo Stock Exchange, Prime Market
Contact: Toshinori Hamada, General Manager ofPlanning & Administration Division
Tel: +81-6-4560-1000

JAST Starts Research Project Using Medical Big Data with Itoigawa General Hospital
Japan System Techniques Co., Ltd. (JAST) has started a joint research project with Itoigawa General Hospital,
which is in the city of Itoigawa in Niigata prefecture. The research involves the use of medical big data fordetermining the relationship between headaches and pharmaceuticals. The details are as per attached.
The earnings forecast announced on May 13, 2022 already incorporates the effect of this matter on the resultsof operations for the fiscal year ending March 2023. An announcement will be made promptly if there is any
additional information that should be disclosed.

Launch the Future

NEWS RELEASE

October 18, 2022
Japan System Techniques Co., Ltd.

JAST Starts Research Project Using Medical Big Data with Itoigawa General Hospital
Japan System Techniques Co., Ltd. (JAST) has started a joint research project with Itoigawa General Hospital, which is in
the city of Itoigawa in Niigata prefecture. The research involves the use of medical big data for determining the relationshipbetween headaches and pharmaceuticals.

■ SummaryApproximately one in four people in Japan have problems with headaches. Substantial expenses are needed for treating
this problem, which can often continue for many years. Furthermore, 8.4% of people in Japan suffer from migraines. In
recent years, there has been progress with the development of migraine acute treatment and preventive drugs. However,there have been instances where excessive dosages of analgesics and triptans (see note 1) for acute treatment haveproduced headaches (headaches due to overuse of drugs) and other problems.
With the cooperation of Dr. Masahito Katsuki of Itoigawa General Hospital, JAST has started a joint research projectwith this hospital that uses medical big data with the goal of learning more about the relationships among migraines,
migraine drugs and headaches caused by the overuse of these drugs.
■ The Joint Research Program
JAST has medical big data derived from the anonymous health insurance invoice data (see note 2) of approximately 8
million people. Information about treatments and prescribed drugs for headaches and migraines in this invoice data will
be used for this joint research. Insurance companies and organizations have given their consent for the use of data they
have provided.
Information about the issues of patients will be analyzed to determine the severity of headaches in order to study any
relationship between the use of drugs and the worsening of headaches. Results of this research will be examined to learn
more about the effects of the excessive use of migraine drugs and outcomes when drugs are used properly.
The information obtained from this research will be provided to healthcare professionals and to insurance companies
and organizations for incorporation in their services for policyholders. At some point, pharmaceutical companies too
may start participating in this research project. In the following fiscal year, which ends in March 2024, results of thisproject are to be announced at an academic conference and a research paper is to be released.
■ Profile of Masahito Katsuki
Masahito Katsuki (Chief of Department Neurosurgery, Itoigawa General Hospital)
Background:
Dr. Katsuki received his M.D. degree at Tohoku University in 2016 and was appointed
chief of Department of Neurosurgery at Itoigawa General Hospital in 2021.
He is a member of The Japanese Headache Society, The Japan Neurosurgical Society,Japanese Association for Medical Artificial Intelligence, and other organizations. In
addition to treating patients with strokes, headaches and other problems, Dr. Katsuki isinvolved with public health activities and medical AI research for the purpose of helping
solve problems concerning the need to invigorate Japan’s economy and provide medicalcare in remote areas of Japan.
1Launch the Future

NEWS RELEASE■ The Future Co-Creation Laboratory of JASTThe Future Co-Creation Laboratory of JAST is a medical big data business with the mission of using the digitaltransformation of health care backed by medical big data (invoice data, health check-up data and other data) to solve
issues at healthcare facilities and insurance companies and organizations. This laboratory will continue to analyze
information obtained from research activities in order to raise the value of JAST’s data and create more ways to solve
the issues of customers.
Operations of The Future Co-Creation Laboratory also contribute to accomplishing Sustainable Development Goals
number three, good health and well-being, and nine, industry, innovation and infrastructure. These activities include theuse of medical big data to enable people to stay healthy and the use of alliances with the academic sector for joint researchand the development of products.

1. Triptans
Triptans are a family of tryptamine-based drugs for the treatment of migraines and cluster headaches. Compared withother headache medications, triptans are a more effective treatment for migraines and are sometimes called a wonderdrug.
2. Health insurance invoices
When an individual receives a medical treatment covered by insurance, the healthcare institution sends an invoice listing
the procedures and amounts due to the insurance company or organization. For medical and dental care, an invoice listing
the procedures and amounts due is sent. For pharmacies, an invoice listing the drugs supplied and amounts due is sent.
For nurses visiting individuals at home, an invoice listing home nursing care services and amounts due is sent. Oneinvoice for each patient and individual healthcare institution is prepared every month. Invoices contain information about
the reasons that individuals received medical care, the cost of the care and other items. JAST converts this information
into a database for subsequent utilization.

■ Inquiries
Japan System Techniques Co., Ltd.
The Future Co-Creation Laboratory
TEL: +81-3-6718-2785
E-mail：JAST-Lab@jast.co.jp

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