AtlaZ
Quantitative Live-Cell Analytics.

AtlaZ

Welcome to the next level oflive-cell analytics
In order to gain a deeper understanding of

AtlaZ provides researchers with the capability tocellular processes, real-time and continuous

investigate various cellular aspects, including cell

monitoring is necessary to access kinetic andadhesion and proliferation, cytotoxicity, GPCR

phenotypic data.

(G-protein coupled receptor) signaling,morphology, and barrier function, label-free andElectrical impedance spectroscopy as thein real-time.

underlying methodology of the AtlaZ system,
coupled with its high throughput capability,

Multiple recording modes, including raw

enables the acquisition of a previously

impedance read-out, displayed as Cell Signal,

unmatched quantity and richness of information.

facilitate freedom of experimental design.

AtlaZ

Key features at a glance
1

Real-time cell analysis

5

Up to 6 x 96 plates simultanously
or independently

2

Label-free experiments

6Electrical ImpedanceSpectroscopy

3

Automated graphing of results

7

Cost efficient consumables

4

Easy to use software withaccess to raw data

8

21 CFR Part 11 compliance in GLP/GMPlabs (coming soon)AtlaZ

Meet your goals and everyday
challenges
Simplicity you will love

the Cell Signal at all available frequencies (fullDifferent recording modes can be chosen

spectrum from 0.1 kHz - 100 kHz) allows to detectfor each plate. The Cytolysis Mode allows fora multitude of physiological effects in cells.

investigations into cell-killing kinetics, the Cell

Experimental workflows with single or multiple

Monitoring Mode facilitates the assessment ofplates are simplified with options such as resuming

GPCR distal effects, and the TEER Mode enables

measurements, or predefining, saving, andthe examination of barrier integrity. Measuringloading treatment layouts.

CellMonitoring

TEER(TransepithelialElectricalResistance)

Cytolysistightjunctions

barrier
integritycell coverage andstrenght of barrier

wound
healing

proliferation /cell density

Recording frequency (kHz)
0.1

1TEER Mode

1025

Cell Monitoring Mode

50100

Cytolysis Mode

AtlaZ

Versatile and fast data analysis
and handling
AtlaZ control is a user-friendly software that• Pre-designed analysis settings for each mode

combines simplicity with immense power. Its• Automated normalization to control group

standardized measurement modes come• Compound effects visible in seconds

with pre-designed recording and analysis• Automated export of analyzed datasettings, enabling a seamless and efficient• Raw data export: Impedance magnitude andanalysis process. Online monitoring of multiple

phase, resistance and capacitanceparameters (KillTime 50, IC50/EC50, Cytolysis (%)• 21 CFR Part 11 compliance in GLP/GMP

and impedance recorded from a large range offrequencies) is displayed in a single screen.

AtlaZ Control
The unique recording modes automatically display data ofinterest. For example the Cell Signal development over time,KillTime 50 values and Cytolysis (%), enveloped by the standard
deviation, indicate the effectiveness of cell treatments.

laboratories (coming soon).

AtlaZ

What do YOU want to explore?

Immuno-oncology / CAR T

Cytotoxicity

Highly reproducible measurements provide a

Test compound toxicity and cytolysis effects on agreat insight into immune cell killing.

wide range of cell types.

Cell characterization / QC

Virology

Suitable for standardized screens, with fast,

Accelerate therapy & vaccine development by realprecise and reproducible results.

time monitoring of viral cytopathic effects (CPE).

GPCR / Receptor signaling

Barrier function (TEER)

Decipher complex cellular signaling andMeasure barrier integrity via Transepithelial

receptor activation.

Electrical Resistance (TEER) detection.

Cell adhesion

Wound healing

Monitor changes in cell number, cell size, cell

Detect cell densities and speed of proliferation ofbarrier function, and cell-substrate attachment.

epithelial or other cells.

AtlaZ

The AtlaZ includes• Recording unit which fits into standard incubators (incubator not included)• Control unit with status display• Recording and analysis software package, pre-installed on convertible laptop• Barcode scanner• Automated multichannel pipetting—Integra Viaflo Assist (optional)• Transparent AtlaZ recording plates (NSP-Z)• 1 year warranty with further optional comprehensive service plans available• Unmatched application supportSpecifications
Supported recording modes

Cytolysis-, Cell monitoring-, TEER signal - mode; full spectrum

Impedance & Frequency resolution

10 mOhm; 100 Hz

Range electrical impedance spectroscopy

0.1–100 kHz

Parallel recording channels

1 x 96 or up to 6 x 96

Readouts

Impedance magnitude and phase, resistance, capacitance

Software license

Not limited to one device

Dimensions recording unit

40,5 x 40,5 x 10 cm

Dimensions control unit

19 x 19 x 18 cm

Automated liquid handling

Integra Viaflow Assist (optional)

Raw data export

Yes

Plates available

Transparent platesaccelerate your researchnanion Europe
info@nanion.dephone: +49 89 2190 95 - 0
www.nanion.denanion USA
info@naniontech.com
phone: 1-888-9-NANION
www.nanion.denanion China
andy.di@nanion.cn
phone: +86 10 82 17 6388
www.nanion.denanion Japan
info@nanion.jp
phone: +81 3 6457 8773
www.nanion.de

To find your nearest Nanion
representative, visit our website:www.nanion.de