BIHADAMAKU™ : Skin-Beautifying Film

NFG for skin care products®

®

What is NFG ?

NFG ® is a premixed composition containing Nissan Chemical's
proprietary ingredient: palmitoyl dipeptide-18. Palmitoyl dipeptide-18 is a lipid peptide molecule combining fatty acids andamino acids to achieve a high safety proﬁle and exceptional properties for the hair and scalp.

Product Name®

NFG ES-01

Composition

INCI（wt%）

Palmitoyl dipeptide-18

10

Stearic acid1

1,2-Hexanediol

4

Laureth-4

8

Water

77

Features of NFG

Skin care functions● Moisturizing and non-sticky feel
● Feels comfortable on the skin

● Promotes penetration of active

co-ingredients● Suppresses of adhesion of pollen

and pollutants (PM2.5)®

Palmitoyl dipeptide-18 has the characteristic of self-organizing in water to form ribbon-like ﬁbers.
When cosmetics containing NFG® are applied, these ﬁbers fold up to adhere to the skin, creating an
ultra-thin ﬁlm, BIHADAMAKUTM, meaning skin-beautifying ﬁlm. Unlike conventional materials, BIHADAMAKUTM is exceptionally soft and has a special structure with nano-sized unevenness on the surface. Nano-sized unevenness suppresses stickiness while maintaining a lasting moisturizing eﬀect.
■Discovered through joint researchwith Kyushu UniversityONH★Palmitic acid
Most abundantfatty acid in skin

BIHADAMAKUTM

HNO

Fiber network formation

OOHNNH★Glycine★Histidine
Amino acid

Selforganization
Fiber formation
20μm

Bottom:cultured skin

Cosmetics containing NFG®
Fibers fold up creating
the ultra-thin ﬁlm:
Dispersion
BIHADAMAKUTMSkin®

Functional data of NFG for skin care
Increases permeation of high molecular weight active ingredients
Penetration promotion mechanism*
1. The self-assembled structure penetrates thelipid lamellar structure of the stratum corneum.
2. Gaps are formed in the lamellar structure andact as passages for active ingredients.

Microscopic
image of skincross section

50 µm

50 µm

Self-organizing
structure

Fluorescencemicroscope
image of crosssection of skin

Activeingredients

Lipid lamellastructure atstratum corneum

Green dyeshows
ﬂuorescently
modiﬁedhyaluronic acid

50 µm

50 µm

Hyaluronic acid water(-) NFG(+) NFG*Takayuki Imoto and Masahiro Goto, Langmuir,2021, 37, 8971−8977《 Evaluation procedure 》
1. Place human skin in Franz cell at 32°
C and apply sample.
2. Hyaluronic acid was quantiﬁed by ﬂuorescence intensity measurement
after 24 hours.

High moisturizing eﬀect

Suppression of adhesion of pollen

Trans Epidermal Water Lossg/（m2・h）

40

Cedar pollen（Diameter: 30μm）

30

Non-treated

20

NFG®

100waterpolymer
moisturizer

NFG ®

《 Evaluation procedure 》《 Evaluation procedure 》

1. Apply sample and remove after 1h.
2. Measure trans epidermal water loss after 6h.
(N=4) (Measuring device: Tewitro TW24)

1. Place human skin in Franz cell at 32°
C and apply sample.
2. Hyaluronic acid was quantiﬁed by ﬂuorescence intensity measurement after 24 hours.

The expressions described in this product description are in accordance with the Pharmaceutical Aﬀairs Law and the Fair Competition Regulations regarding thelabeling of cosmetics. It does not indicate the eﬀects and eﬃcacy of cosmetics and quasi-drugs within the range approved. We do not guarantee industrial
property rights such as patents. A separate survey is required.

5-1, Nihonbashi 2-chome, Chuo-ku,
Tokyo 103-6119, Japan

Planning & Development Div.
Healthcare Business Development Dept.
URL : http://www.nissanchem.co.jp
E-mail : pdd-ls@nissanchem.co.jp

2023.5.17 BR0000