April 5, 2017

Mandom received Paper Award at the94th Annual Meeting of the PhysiologicalSociety of Japan
Mandom Corporation (Head Office: Osaka, President Executive Officer: Motonobu Nishimura, hereafter“Mandom”), have been conducting joint research with Professor Makoto Tominaga at the National Institutes of
Natural Sciences and the Okazaki Institute for Integrative Bioscience for the purpose of developing t evaluation method
using TRP (Transient Receptor Potential) channels. Furthermore we try to apply our findings to development of ourproducts.
Our research showed that capsaicin, the warming agent, suppresses activity of TRPM8, cooling sensor. On the otherhand, menthol, the cooling agent, suppresses activity of TRPV1, warmth sensor. These findings was published in the“Journal of Physiological Sciences” and we received the “Hiroshi and Aya Irisawa Memorial Award for Excellent Papers
in The Journal of Physiological Sciences 1”.
We will continue to work developing our technical improvement of sensory stimulation.

[Topic & Outline of the Winning Paper]

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URL: https://www.mandom.co.jp/en/

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-1-(1) Title
Reciprocal effects of capsaicin and menthol on thermo-sensation through regulated activities of TRPV1 andTRPM8(2) Publication
Journal of Physiological Sciences March 2016, Volume 66, Issue 2, pp 143–155(3) Researchers
Mandom Corporation:
Masayuki Takaishi, Hiroshi Matsui, Tadashi Shimada, Fumitaka Fujita
National Institutes of Natural Sciences & Okazaki Institute for Integrative Bioscience:
Kunitoshi Uchida, Yoshiro Suzuki, Makoto Tominaga(4) Contents
We have discovered that menthol, the well-known cooling agent, suppresses the activity of TRPV1 (a warmthsensor), and that capsaicin, the well-known warming agent, suppresses the activity of TRPM8 (a coolnesssensor). These results suggest that temperature sensation induced by chemical was not only activation of one
thermo-sensor but also inhibition of opposite thermo-sensor.
Additionally, we have found that the sensory irritation through the activation of the TRPV1 receptor wasalleviated by menthol. Thus, we clarify one of analgesic mechanism of action induced by menthol2.

<Notes>*1 Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences
Each year the Physiological Society of Japan offers an award to the author(s) of outstanding papers published in
the Journal of Physiological Sciences (formerly the Japanese Journal of Physiology). This award is named inhonor of Dr. Hiroshi Irisawa, a well-known cardiac physiologist. Based on the Hiroshi Irisawa Fund, the award
is sponsored by the Physiological Society of Japan. Its purpose is to promote the contribution of high-quality
papers particularly those written by junior members of the Society. The selection of the award is theresponsibility of the selection committee, whose members are JPS Editors and Officers of the PhysiologicalSociety of Japan.
Excerpted from the website of the Physiological Society of Japan*2 “Mandom identified menthol-induced analgesic mechanisms,” (released December 10, 2015)
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