Detecting & repairing hair damage

NFG for hair care products®

®

What is NFG ?

NFG ® is a premixed composition containing Nissan Chemical's
proprietary ingredient: palmitoyl dipeptide-18. Palmitoyl dipeptide-18 is a lipid peptide molecule combining fatty acids andamino acids to achieve a high safety proﬁle and exceptional properties for the hair and scalp.

Product Name®

NFG ES-01

Composition

INCI

Hair care functions（wt%）

Palmitoyl dipeptide-18

10

Stearic acid1

1,2-Hexanediol

4

Laureth-4

8

Water77

Features of NFG®

● Improves hair manageability● Boosts elasticity● Suppresses frizziness● Promotes penetration of active

co-ingredients● Quickly dries hair, saving time andenergy

When NFG ® is added to hair care products, palmitoyl dipeptide-18
forms a ﬁlm on the hair surface, which provides a smooth, silky touch.
This ﬁlm also acts as a protective coat that penetrates into the cortexof hair strand and allows for damaged segments to be repaired.
10

∙103
1.2

125

125

100

100

0.875ON
H★Palmitic acid
Most abundant fatty
acid in skin and hairHNO

40800.2754500.4■25Hair care products
containing NFG®
0μm 06750.650■Discovered through joint researchwith Kyushu University

50225Forms a ﬁlm on the hair surface

0.0

12000μm 0total
MC: 1317; TC: 6.151e+007

4080120∙10Dry1.02125

NH

1.2
1.0
100

442441444125
3100

0.80.675★Glycine★Histidine
Amino acid

41

∙103

0.8
100

4080
Cross
sectionof120hair
Overlay of C H O N -, CNO-, C H O N -0μm 024125N

25Blue dye showing palmitoyl
dipeptide-18C4 H5O4MC: 10; TC: 9.410e+004

OOH

125

81.0

100

0.4500.2

25

hair μm0 00.04080

CNOMC: 110; TC: 1.138e+006

12075

75

20.650

500.4

250.2

00.0μm 04080

120

total
MC: 1317; TC: 6.151e+007

12500μm 04080

120

C24 H41O4N4MC: 4; TC: 3.167e+003

Palmitoyl dipeptide-18 ﬁlls the holes in the damaged cuticle CMC that causes hair troubles.
This stops the progression of damage leadingto beautiful and supple hair.
〈Hair Structure Model〉
Cortex

MedullaCuticle CMC■ Damaged cuticle CMC■ Damage repaired by NFG®

WaterWaterCuticle

β layer δ layer β layer（Lipid） （Protein）（Lipid）

®

Functional data of NFG for hair careMakes hair supple and manageable
Treated witha conditioner
including NFG ®

Black hair

Bleached hair

1.2

Tensile strength（N）

Treated withconditioner only

Improves hair elasticity

1.1

1.0

0.9

0.8

Untreated

Untreated《 Evaluation procedure 》《 Evaluation procedure 》

1. Apply conditioner to bleached hair.
2. Dry with a hair dryer after rinsing.

1. Apply conditioner to bleached hair.
2. Dry with a hair dryer after rinsing.

Treated with conditioner(ｰ) NFG ®

(+) NFG ®

Suppresses frizziness even under high humidity

Promote penetration of active ingredients

10 minutes after humidiﬁcation (Humidity 95%)

Active ingredient：Succinic acid (light blue)

Treated withconditioner only

Treated witha conditioner
including NFG ®

Treated withconditioner only

Treated witha conditioner
including NFG ®

Succinic acid
penetrates into the hair
《 Evaluation procedure 》《 Evaluation procedure 》

1. Apply conditioner to curly hair.
2. Dry with a towel after rinsing.
3. Dry with a hair dryer for 5 minutes.
4. The hair was straightened with a curling iron.
5. Humidiﬁed, and the waviness/frizziness of the hair was evaluated.

1. Apply conditioner to bleached hair and rinsed.
2. Evaluate succinic acid in the cross section of the hair byTOF-SIMS.

The expressions described in this product description are in accordance with the Pharmaceutical Aﬀairs Law and the Fair Competition Regulations regarding thelabeling of cosmetics. It does not indicate the eﬀects and eﬃcacy of cosmetics and quasi-drugs within the range approved. We do not guarantee industrial
property rights such as patents. A separate survey is required.

5-1, Nihonbashi 2-chome, Chuo-ku,
Tokyo 103-6119, Japan

Planning & Development Div.
Healthcare Business Development Dept.
URL : https://www.nissanchem.co.jp/eng/
E-mail : pdd-ls@nissanchem.co.jp

2023.5.17 BR100