News Release Dated March 26, 2024
Company: Japan System Techniques Co., Ltd.
Representative: Takeaki Hirabayashi, President and CEO
Stock code: 4323, Tokyo Stock Exchange, Prime Market
Contact: Taku Hirabayashi, Director and Officer
Tel: +81-6-4560-1000

JAST Starts New Product Development Using Medical Big Data
Japan System Techniques Co., Ltd. (JAST) has started activities for the development of new products withJapan Weather Association. These activities are using the Medical Data PROVISION product development
environment. The details are as per attached.
This matter will have only a negligible effect on JAST’s results of operations. An announcement will be madepromptly if there is any additional information that should be disclosed.

Launch the Future

NEWS RELEASE

March 26, 2024
Japan System Techniques Co., Ltd.

JAST Starts New Product Development Using Medical Big Data

Japan System Techniques Co., Ltd. (JAST) has started activities for the development of new products with Japan Weather
Association (Headquarters: Toshima-ku, Tokyo; Director General: Kazuhiro Watanabe). These activities are using the Medical
Data PROVISION product development environment.

Japan System Techniques Co., Ltd.

×Japan Weather Association◼

Background

There is growing interest in health problems that are associated with changes in barometric pressure, temperature, humidity
and other meteorological parameters. These problems are causing difficulties for many people in Japan. Many other weatherrelated health issues familiar to the Japanese, such as allergic rhinitis (hay fever) and influenza, also require attention. At thesame time, uncertainties about the supply of pharmaceuticals are increasing. Causes include falling profitability due toinsurance drug price cuts and other government measures to hold down the cost of drugs as well as an increasingly complex
supply chain extending from production to issuing prescriptions.
To seek solutions for these problems, JAST has for years been working on co-creation programs that utilize the company’sREZULT medical big data platform and the resources of partners in the corporate and academic sectors. Japan Weather
Association uses services involving the weather, environment, disaster preparedness and information to contribute to publicsafety. By working together, JAST and the Japan Weather Association aim to develop products that will help maintain anefficient and stable supply of pharmaceutical products.
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Objectives

JAST and Japan Weather Association will analyze medical big data and meteorological data for the purpose of creating amodel for forecasting the volume of prescriptions for specific drugs according to weather conditions. Plans also include thedistribution of real-time prescription volume data and forecasting results based on this model through reports, dashboards,
data marts, and other formats to meet customer needs.
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Start of Development Program

April 2024 or later◼

Roles of JAST and Japan Weather Association

JAST:

Provision of medical big data, chiefly health insurance invoices*, and development of adashboard that uses a forecasting model

Japan Weather Association:

Provision of observations, forecasts and other meteorological data, studies concerning therelationship between medical big data and meteorological data, and development of aprescription volume forecasting model1

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Relationship between Prescription Volume and the Weather

The larger the increase in weekly rainfall
vs. the previous week, the larger theincrease in prescription volume

Allergic rhinitis_Olopatadine hydrochloride
Allergic rhinitis_Montelukast
sodiumPrescription volume annual average

Prescription volume annual average

Allergic rhinitis_L-carbocisteine

Allergic rhinitis_Acetaminophen
Migraine_Loxoprofen sodium hydrate

Allergic rhinitis
VertigoAsthma coughMigraine
Manic-depression

Manic-depression_Tylium carbonate
Acetaminophen

The larger the increase in weekly rainfall
vs. the previous week, the larger theincrease in prescription volume

Name of disease_Nameof drug component

Migraine_Valproate sodium
Migraine_Loxoprofen sodium hydrate
Vertigo_Petahis mesylate
Migraine_Etizolam
Migraine_Acetaminophen
Manic-depression_Quetiapine
Vertigo_Mecoparamine
Fumarate Acetaminophen
Manic-depression_Flunitrazebam

Manic-depression_Tylium carbonate

Vertigo_Etizolam

Manic-depression_Alprazolam

The larger the increase in weekly rainfall in the previous week

The larger the increase in weekly rainfall in the previous week

Weather sensitivity (Current/Previous weekly rainfall)

Weather sensitivity (Current/Previous weekly rainfall)

Figure: Study of relationship between prescription volume and rainfall between August and OctoberThis study clearly showed that a larger increase in rainfall from one week to the next results in a larger increase in the volumeof prescriptions for drugs often used for treating allergic rhinitis, migraines and vertigo. There are other strong seasonalcorrelations between prescription volumes and changes in the weather. As a result, there is clearly a relationship between theweather and diseases and the volume of prescriptions for drugs to treat these disorders.

■ Upcoming Activities
JAST and Japan Weather Association plan to use the start of this new business activity as an opportunity to seek new ways
for the utilization of data with companies in other business sectors by using the Medical Data PROVISION productdevelopment environment. The goal is to use these activities for expanding the use of new products to more market categories
in order to create new drivers of growth quickly.

■ The Medical Data PROVISION Product Development Environment
Medical Data PROVISION is an all-inclusive service that encompasses licensing the use of the JAST’s REZULT medical big
data platform, a highly secure environment for using sensitive data, and advisers with medical big data utilization expertise.
JAST is using Medical Data PROVISION for co-creation programs with partners in the corporate and academic sectors.

Use this URL for more information about the Medical Data PROVISION
https://www.jastlab.jast.jp/mdp/2

Launch the Future◼

NEWS RELEASE

Use this URL for more information about the REZULT medical big data platform

https://www.jastlab.jast.jp/rezult_data/◼

The Future Co-Creation Laboratory of JASTThe Future Co-Creation Laboratory of JAST is a medical big data business with the mission of using the digital transformationof health care backed by medical big data (health insurance invoice data, health check-up data and other data) to solve issues
at healthcare facilities and insurance companies and organizations. This laboratory will continue to analyze information
obtained from research activities in order to raise the value of JAST’s data and create more ways to solve the issues ofcustomers.
Operations of The Future Co-Creation Laboratory also contribute to accomplishing Sustainable Development Goals number
three, good health and well-being, and nine, industry, innovation and infrastructure. These activities include the use of medical
big data to enable people to stay healthy and the use of alliances with the academic sector for joint research and the developmentof products.

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Profile of Japan Weather Association

Established in 1950, Japan Weather Association was Japan’s first private-sector company that provides consulting services
involving the weather. Activities include measures to prepare for natural disasters and minimize damage and information about
the weather for operators of offshore wind power sites. Services also extend to products and electricity demand forecasting
based on meteorological data, information about climate change countermeasures, and other forms of consulting. Japan
Weather Association remains at the forefront of this business sector by continuing to create new ways to use meteorologicaldata. With a team of more than 350 weather forecasters, one of Japan’s largest, Japan Weather Association is dedicated toproviding support to companies concerning ESG investments and SDG-related activities.
* Health insurance invoices
When an individual receives a medical treatment covered by insurance, the healthcare institution sends an invoice listing theprocedures and amounts due to the insurance company or organization. For medical and dental care, an invoice listing theprocedures and amounts due is sent. For pharmacies, an invoice listing the drugs supplied and amounts due is sent. For nurses
visiting individuals at home, an invoice listing home nursing care services and amounts due is sent. One invoice for eachpatient and individual healthcare institution is prepared every month. Invoices contain information about the reasons thatindividuals received medical care, the cost of the care and other items. JAST converts this information into a database forsubsequent utilization.

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Inquiries

Japan System Techniques Co., Ltd.
The Future Co-Creation Laboratory
Contact: https://www.jastlab.jast.jp/contact/
Website of The Future Co-Creation Laboratory: https://www.jastlab.jast.jp/3