CIBoG/GTR Joint Seminar

Dr. Yann Guérardel
Director, Institute for Structural and Functional Gycobiology (UGSF), UMR, CNRS, Lille University
Designated Professor, iGCORE, Gifu University

Apprehending structural and functional diversity of glycans
January 18th(Mon), 2021
15:00-16:30 (On Zoom)
URL：
https://us02web.zoom.us/j/86502015266?pwd=ai9JbGl1emZ4cERyZ3VrYmxmSDloZz09
Education/trainingMeeting
ID: 865 0201 5266
1999-2002PhD in Biochemistry, Lille University, France
Passcode: evEK36

Positions and honors
2003–2004 Post-doctoral fellows, Institute of BiologicalChemistry, Academia Sinica, Taiwan
2004–2013 Research Fellow for the CNRS, UGSF, UMR CNRS
8576, Lille University, France
2006
Invited Professor, University of Nagoya, Japan
2013– Research Director for the CNRS
2013–2019 Executive Director, Institute for Structural andFunctional Glycobiology. Lille
2020– Director, Institute for Structural and Functional
Glycobiology. Lille

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Personal Statement
Carbohydrates, also called glycans,are the most abundant and diverse biological
I have been trained in structural analysis of glycans. My main scientific interest concerns the structure
to function relationships of complex carbohydrates ranging from microorganisms to higher eukaryotes,
molecules on Earth and make up
part of the biology of all living organisms.
mostly in the context of host-pathogen interaction with a keen interest for mycobacterial and fungus
infections.
My main glycoconjugates,
objective is to understand how the theyglycans frombothdistributed
host and pathogen fine tune
Associated to other biomoleculesthe toform
areinfectious process and how can they be used as diagnosis or therapeutic targets. To achieve it, I havetogether antheyinterdisciplinary
team thata wide range functionsof scientific approaches
in all classes of living organisms put
whereplayresearch
myriadofintegrates
biologicalincluding synthetic chemistry, structural analysis using NMR and mass spectrometry, structural biology
of proteins and enzymology. cell-cell and molecule-moleculein energy reserve, molecular arrangements,
Messageto the Younger
Generationinteractions, regulation of protein
stabilityetc.
Despite their fundamental roles
This is a true pleasure and honor for me to deliver a message to the younger generation of
in all part of biology, the study ofglycans
behindthoseotherofchanceglycobiologists.
I havelag
been working
in this field
since myof
Masterdegree inclasses
1999 and had theto directly learn advanced notions of glycobiology from great scholars and scientists among which Pr
biomolecules such as proteins Andréandnucleicacids,
mostlyofKay-Hooi
theirKhoo in
Verbertand Gérard Strecker
in France,
Pr John K. because
Sheehan in England,
Taiwan and Ken Kitajima in Japan. They enlightened me with very different and personal understanding
complexity. During this lecture, wewill firsttheup chemicalof glycobiology
on introduce
which I have beenwhat
relying toisbuild
my own researchorigin
and become a“glycomaniac”. Aside scientific skills and views, the most important notions I have learned from theirof carbohydrate diversity and thenbriefly
thisstructuralteachingsand duringdescribe
my career are to how
be creative,
to be attentive
to new ideasdiversity
and to always believe
and follow my own research path, irrespective of the sometimes elusive trends and fashions of the time.
can be evaluated by a combination
physico-chemicalmethodsgasconsider
Despite of
the many
discoveries that paved the way
toward modernincluding
glycobiology, I still
glycobiology as an almost virgin territory to be explored and which frontiers are yet to be drawn. As an
and liquid chromatography, mass
spectrometry and NMR. Finally, we will
example, we all know the general features and functions of major glycans in eukaryotic organisms, butmuch is yet to be discovered about their structural diversity and even more about the regulation ofhighlight the clinical importancesotheirof
carbohydrates through the presentation ofexquisite expression specificities. Thus, we have now to figure out what are the cell-type andenvironment-dependent patterns of expression of every single motifs in order to fully understand theseveral examples.
functions of particular glycans, irrespective of the chosen model. To face this immense challenge, weare a very small but tight community of scientists who have to find new ways of doing things. One isto work together in a totally transparent manner, to share information and know-how within national
連絡先：糖鎖⽣命コア研究所 統合⽣命医科学糖鎖研究センター
北島健（内線4297）
and international networks in order to push forward
our individual
expertise andimpact. The other is todiffuse as much as possible glycobiology outside our traditional circles and to convince scientists fromother fields that integrating glycosylation into their conceptual frameworks will be beneficial for all thecommunity. Thus, only by gathering forces from within and outside our community shall the next
generation be able to dig out the gold that lies under the surface.