Kanto Diagnostics（AMI：Acute Myocardial Infarction）

Characteristics
 The measurement principle is Latex turbidimetric immunoassay.
 No interference is observed by Human antimouse
antibody(HAMA) since this is used Goat polyclonal antibody.
 It is useful as a super-acute phase marker of acute myocardial
infarction (AMI).
 It is possible to be a more reliable diagnosis by Combining with
CicaLiquid CK-MB.

Kanto Diagnostics

Time to hospitalization from the onset of AMI

24-48hr
12-24hr

6-12hr0-6hr

Ref. Miyagi Prefecture myocardial infarction measures Council '30 History

Relationship between the hospital visiting routeand the time to treatment from the onset of AMI

By ambulance
直接救急車搬送3.9
7.5

By other than ambulance
救急車以外で来院

By way of the medical
専門医以外の医療機関を経由
institution other than expert

012.4
5

1015時間（hr）
hourRef. Research of the Ministry of Health, Labour and Welfare research groups(The Asahi Shimbun Companyasahi.com 2010/8/7)

Kanto Diagnostics

The multiples for the cut-off
upper limit

Temporal changes of each cardiac muscle marker

18The mean peak time of AMI15Mb（Mean 8.3h）
CK-MB（Mean 19.5h）

12963102040

The time from the onset of AMI（h）

Mb and CK-MB in the ultra-acute phase of AMI
MarkerCKCK-MB
Mb

Shortest
Sensitivity(Time from onset)
detection
Specificity
0 - 2(hr) 2 - 4(hr) 4 - 6(hr)time(hr)
Ｘ78% 2-4hr later
24%
40%
78%
24%
40%
70%
94%
2-4hr later
75%
83%
91%
70%
1-2hr later

Longestdetectiontime(hr)

All cases
positive time(hr)24hr later
24hr later
24hr later

8-12hr later
8-12hr later
4-8hr later

Ref. Med Technol 2008．36；358-361．Table 2, 3

★ Points•••

Myoglobin (Mb) will appear in the blood faster than CK and CK-MB after
the onset of Acute myocardial infarction (AMI).
Mb will be a valid marker if it is within 8 hours from the onset of AMI. If itis later, CK-MB will be a valid marker.
If you do not know the time from the onset of AMI, it is possible to morereliable diagnosis by measuring Mb and CK-MB.

Kanto Diagnostics
Limit of detection

Highvalue serum
高値血清1500

150

Lowvalue serum
低値血清1200120900

9060060300300020

301020

510

000

1234
希釈系列(n/5)
Dilutionseries(n/10)

Within-run precision

Correlation

24

6840

15

希釈系列(n/10)
Dilutionseries(n/10)050

Minimum：1.5 ng/mL
Effective sensitivity：8 ng/mL

10

234

n20

20

2020

mean 25.93

65.26 163.38 293.28

max

28.4

67.9

168.4

301.9

min

22.9

62.8

156.0

284.0

range

5.5

5.1

12.4

17.9

SD

1.517

1.497

3.311

4.216

CV(%)

5.85

2.29

2.03

1.44

CiasLatex
Mb(ng/mL)
本品(ng/mL)

1400
n = 162y = 0.973x + 0.157
r = 0.9986

00（Unit：ng/mL)

200
400
600
他社LTIA(ng/mL)

Dilution re-examination
concentration range

2000

1000

00600012000 18000
Expectedvalue(ng/mL)
期待値(ng/mL)

Open stability

600

200

3000

5800

SampleC.V.(%)
本品(ng/mL)
CiasLatex
Mb(ng/mL)

25180

本品(ng/mL)
CiasLatex
Mb(ng/mL)

本品(ng/mL)
CiasLatex
Mb(ng/mL)

1800

Zone phenomenon

800

CiasLatex本品(ng/mL)又は対初日値(%)
Mb(ng/mL) or value for the first day(%)

Linearly120
Calibration：First day and last day

1008060Measured value
測定値
Value for the first

対初日値%
day(%)

40

Another LTIA(ng/mL)

08162432Days
開栓後の日数

Product list

CODE

PRODUCT NAME

TYPE

78204

CiasLatex Mb

S78205

Mb Calibrator

S78206

Qualitrol MYO

S

CONTENTS
Reagent 1
Reagent 2
Standard
Solvent
Level 1
Level 2PACKAGE
60mL×1
10mL×11mL×1×5conc.
6mL×11mL×51mL×5

STORAGEEXPIRY

2 - 8℃

1 yearBelow-20℃

18 months