News Release Dated December 7, 2023
Company: Japan System Techniques Co., Ltd.
Representative: Takeaki Hirabayashi, President and CEO
Stock code: 4323, Tokyo Stock Exchange, Prime Market
Contact: Taku Hirabayashi, Director and Officer
Tel: +81-6-4560-1000

Report on Joint Research with Itoigawa General Hospitalat the 51st Assembly of the Japanese Headache Society
Results of analysis using the REZULT medical big data platform
Japan System Techniques Co., Ltd. (JAST) has been performing research jointly with Itoigawa General
Hospital concerning the relationships among migraines, migraine drugs and headaches caused by the overuseof these drugs. The results of this joint research were announced at the 51st Assembly of the Japanese
Headache Society. The details are as per attached.
The earnings forecast to be announced on May 12, 2023 incorporates the effect of this matter on the resultsof operations for the fiscal year ending March 2024. An announcement will be made promptly if there is any
additional information that should be disclosed.

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NEWS RELEASE

December 7, 2023
Japan System Techniques Co., Ltd.

Report on Joint Research with Itoigawa General Hospitalat the 51st Assembly of the Japanese Headache SocietyResults of analysis using the REZULT medical big data platform
Japan System Techniques Co., Ltd. (JAST) has been performing research jointly with Dr. Masahito Katsuki concerning therelationships among migraines, migraine drugs and headaches caused by the overuse of these drugs. Dr. Katsuki is aneurosurgeon and provides outpatient headache care at Itoigawa General Hospital and Japanese Red Cross Suwa Hospital.
The results of this joint research were announced at the 51st Assembly of the Japanese Headache Society.

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Background

Approximately one in four people in Japan have problems with headaches. Substantial expenses are needed for treating thisproblem, which can often continue for many years. Furthermore, 8.4% of people in Japan suffer from migraines. In recentyears, there has been progress with the development of migraine acute treatment and preventive drugs. However, there havebeen instances where excessive dosages for acute treatment have produced headaches (headaches due to overuse of drugs)
and other problems.
With the cooperation of Dr. Katsuki, JAST started a joint research project in October 2022 with this hospital. The project uses
medical big data with the goal of learning more about the relationships among migraines, migraine drugs and headaches
caused by the overuse of these drugs.
(For more information: https://www.jast.jp/cms/wp-content/uploads/2022/10/ir_notice20221018.pdf)

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Outline of the Conference

Name:
Theme:
Date:
Location:
Program:◼

The 51st Assembly of the Japanese Headache Society
Caring for Patients with the Latest Headache Treatments Resulting from Revolutionary Progress
December 1 and 2, 2023
Conference Center, PACIFICO Yokohama (1-1-1, Minato Mirai, Nishi-ku, Yokohama, Kanagawa)
http://jhs51.umin.jp/program.html

Presentation

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NEWS RELEASE

Use of the REZULT medical invoice data platform for analysis of headaches caused by overuse of iatrogenic drugs
December 2, 2023 2:20PM – 3:20PM General themes 25 – Headaches 2

Summary of the Research ProjectThis research project consists of two elements involving treatment patterns for individuals with headaches. One is crosssectional research. The other is longitudinal studies for the observation of changes over time. Two iatrogenic drugs appear tobe used excessively: Triptans and combined analgesics (30 tablets/90 days or more) and analgesics alone (45 tablets/90 daysor more).
Cross-sectional research used medical invoice data in 2020 to examine the level of excessive use of iatrogenic drugs during
the 90-day period when the amount of drugs prescribed is greatest for the acute phase of treatment. The study revealed that
1,992 individuals (12.8% of the total) of the 15,524 who were prescribed acute care treatment drugs received an excessive
amount of drugs.
Longitudinal research used medical invoice data between 2010 and 2022 to determine patterns for prescribing drugs during
the first two years following an initial diagnosis. The study covered 545,021 individuals during this two-year period andrevealed that 40,082 individuals (10.1% of the total) had experienced excessive drug prescriptions.

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Upcoming Activities

This research project showed that 12.8% of individuals who received prescriptions for headaches were given an excessive
amount of drugs. In addition, 10.1% of individuals were given an excessive prescription within two years of the diagnosis of
the cause of their headaches. Both patients and healthcare providers need to understand the risks associated with the excessive
use of headache drugs in order to use drugs for treating acute headaches properly. To provide more knowledge about theexcessive use of iatrogenic drugs, the members of this project plan to study activities for educating health insurers, patientsand healthcare facilities.
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Use this URL for more information about The Japanese Headache Society.

https://www.jhsnet.net/◼

Use this URL for more information about the REZULT medical big data platform.

https://www.jastlab.jast.jp/rezult_data/2

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NEWS RELEASEThe Future Co-Creation Laboratory of JASTThe Future Co-Creation Laboratory of JAST is a medical big data business with the mission of using the digital transformationof health care backed by medical big data (health insurance invoice data*, health check-up data and other data) to solve issues
at healthcare facilities and insurance companies and organizations. This laboratory will continue to analyze information
obtained from research activities in order to raise the value of JAST’s data and create more ways to solve the issues ofcustomers.
Operations of The Future Co-Creation Laboratory also contribute to accomplishing Sustainable Development Goals number
three, good health and well-being, and nine, industry, innovation and infrastructure. These activities include the use of medical
big data to enable people to stay healthy and the use of alliances with the academic sector for joint research and the developmentof products.

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Profile of Masahito Katsuki

Masahito Katsuki (Department of Neurosurgery, Itoigawa General Hospital, Department of Neurosurgery, HeadacheOutpatient, Japanese Red Cross Suwa Hospital)
Background:2016: M.D. degree at Tohoku University
2021: Chief of Department of Neurosurgery at Itoigawa General Hospital
2023: Department of Neurosurgery, Headache Outpatient, Japanese Red Cross Suwa Hospital
Dr. Katsuki is a member of The Japanese Headache Society, The Japan Neurosurgical Society, Japanese Association for
Medical Artificial Intelligence, and other organizations. In addition to treating patients with strokes, headaches and otherproblems, Dr. Katsuki is involved with public health activities and medical AI research for the purpose of helping solve
problems concerning the need to invigorate Japan’s economy and provide medical care in remote areas of Japan.
* Health insurance invoices
When an individual receives a medical treatment covered by insurance, the healthcare institution sends an invoice listing theprocedures and amounts due to the insurance company or organization. For medical and dental care, an invoice listing theprocedures and amounts due is sent. For pharmacies, an invoice listing the drugs supplied and amounts due is sent. For nurses
visiting individuals at home, an invoice listing home nursing care services and amounts due is sent. One invoice for eachpatient and individual healthcare institution is prepared every month. Invoices contain information about the reasons that
individuals received medical care, the cost of the care and other items. JAST converts this information into a database forsubsequent utilization.

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Inquiries

Japan System Techniques Co., Ltd.
The Future Co-Creation Laboratory
Contact for more information (redirected to an external website): https://www.jastlab.jast.jp/contact/
Website of The Future Co-Creation Laboratory: https://www.jastlab.jast.jp/3