What to do if you missa dose of GENVOYA
Combination Tablets /Precautions

Director of AIDS Clinical Center
National Center for Global Health and Medicine

Side effects

How to take GENVOYA
Combination Tablets

Editorial Supervisor

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

For People
Taking GENVOYA®
Combination Tablets
Shinichi Oka

Effects of GENVOYA
Combination Tablets

Introduction /Table of contents

Introduction
This leaflet was created for people who take GENVOYA Combination Tablets.
This leaflet includes information about the characteristics of GENVOYA
Combination Tablets, how to take GENVOYA Combination Tablets, what to do if
you forget to take GENVOYA Combination Tablets, the side effects of GENVOYA
Combination Tablets, and precautions for taking GENVOYA Combination Tablets.
Read this leaflet thoroughly before taking GENVOYA Combination Tablets.

A medical decision needs to be made based on your circumstances before
starting the administration of GENVOYA Combination Tablets.
Listen carefully to the explanation provided by your healthcare providers(physicians, nurses and pharmacists) and follow their instructions.

If you have any questions about the administration of GENVOYA Combination
Tablets, consult your healthcare providers (physicians, nurses and pharmacists).

This leaflet is a revised Japanese version of the “Patient Information of GENVOYA” which accompanies “GENVOYA
Full Prescribing Information” in the U.S.
The content was compiled under the supervision of Dr. Shinichi Oka (Director of AIDS Clinical Center, National
Center for Global Health and Medicine)11Introduction

3

What are GENVOYA Combination Tablets?
● Characteristics of GENVOYA Combination Tablets● Effects of GENVOYA Combination Tablets● Concomitant use of GENVOYA Combination Tablets with other medicines

9

What should you do if you miss a dose of
GENVOYA Combination Tablets?

10Precaution for taking GENVOYA
Combination Tablets● If you are infected by hepatitis B virus

11

What are the side effects of GENVOYA
Combination Tablets?

13

Taking GENVOYA Combination Tablets
during pregnancy?

How to take GENVOYA
Combination Tablets

How should GENVOYA Combination Tablets be taken?

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions

5

Introduction /Table of contents

Table of contents

Effects of GENVOYA
Combination Tablets

For People Taking GENVOYA
Combination Tablets● If you would like to know more about HIV infection

14

Is there anything else you should know?

Side effects● Breast-feeding● Precautions in everyday life
● How to uncap the container of GENVOYA Combination Tablets

15

APPENDIX Meals

2

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information● How to store GENVOYA Combination Tablets

What are GENVOYA
Combination Tablets?
GENVOYA is a medicine for HIV infection that reduces the amountof the virus in the blood1).
When GENVOYA Combination Tablets are administered and HIV activity in the blood is suppressed,
immune-compromised patients recover some of their immune function and are less likely to acquire
opportunistic infections2).

Note 1)

Herpesvirus
infection

Amount of virus in the blood

The amount of virus in the blood is represented by the viral count in 1 mLof plasma. It indicates the treatment start time and/or the effects of theanti-HIV medicines. The goal of treatment is to maintain a viralconcentration that is below the detection limit over a long period of time.
Note 2)

Candidaesophagitis

Opportunistic infections

Signifies infections caused by weakly pathogenic microorganismsthat do not cause infections in people with normal immune function.
Opportunistic infections include candida esophagitis, herpesvirus
infection, and Mycobacterium avium complex (MAC) infection.

Mycobacterium
avium
complex (MAC)
infection

Characteristics of GENVOYA Combination Tablets
GENVOYA Combination Tablets contain four medicines, including elvitegravir, cobicistat, emtricitabine,and tenofovir alafenamide fumarate in one tablet. You can take four types of medicines with a once dailyadministration of only one tablet of GENVOYA, thus reducing the burden of administration. GENVOYA
Combination Tablets may not be taken concomitantly with any other anti-HIV medicine.
GENVOYA does not completely cure HIV infection or AIDS through short-term administration, but
suppresses HIV activity through continued administration. Continued treatment is required, while taking
precautions against opportunistic infections and other symptoms.

3Introduction /Table of contents

is included to increase elvitegravir’s effects. In addition, emtricitabine and tenofovir
alafenamide fumarate are nucleoside reverse transcriptase inhibitors. HIV uses various enzymes
specific to the virus in its course of multiplication in the human body. Elvitegravir inhibits theactivity of an enzyme called “HIV integrase,” while emtricitabine and tenofovir alafenamide
fumarate inhibit the activity of HIV reverse transcriptase to prevent HIV from multiplying.

HIV
CCR5 inhibitor

Integrase inhibitor
Absorption/fusion
CD4 receptor

Elvitegravir

How to take GENVOYA
Combination Tablets

Elvitegravir contained in GENVOYA Combination Tablets is an integrase inhibitor, and cobicistat

Effects of GENVOYA
Combination Tablets

Effects of GENVOYA Combination Tablets

Cobicistat

Invasion
IntegrationDNA
synthesis
HIV RNAmRNA

Reversetranscription

Budding/Release

CD4 cellNucleoside reverse
transcriptase inhibitor

Protease inhibitor

HIV reverse transcriptase

Emtricitabine

HIV protease

Tenofovir alafenamide

HIV integrase

4Side effects

ProteinProteinsynthesis degradation/
modification

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

Non-nucleoside reverse
transcriptase inhibitor

Assembly

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions

Increase the effectof elvitegravir

How should GENVOYA Combination
Tablets be taken?
In general, take one tablet of GENVOYA once a day after a meal3).
Only one tablet needs to be taken for treatment with GENVOYA
Combination Tablets.
GENVOYA Combination Tablets may not be taken concomitantly with anyother anti-HIV medicine.
GENVOYA is a green tablet, as shown in the pictures below, and contains
elvitegravir (150 mg), cobicistat (150 mg), emtricitabine (200 mg), andtenofovir alafenamide fumarate (11.2 mg) in one tablet.

Top view

Bottom view

Side view

Take one GENVOYA tablet once a day after a meal3).
Take it within 30 minutes of eating if possible.

Note 3)As a guideline, take a meal totaling over 250 kcal
before taking GENVOYA.

Examples of food with approximately 250 kcal
• One rice ball with tuna and mayonnaise• Two egg sandwiches• One croissant• One cream puff
• High calorie nutrition-supplement drink withapproximately 250 kcal

Take GENVOYA after eating a light meal even when you cannot eat normally or if you have irregulareating patterns.
Taking the medicine every day is of the utmost importance for continuously suppressing the activity of thevirus. If you miss taking the medicine for even a short period of time, the virus may multiply in the body or
the medicine may become ineffective, and symptoms may worsen. Follow your doctor’s instructions andtake GENVOYA Combination Tablets and other medicines properly every day. In addition, continue toconsult with your doctor regularly concerning your condition.

5

Introduction /Table of contentsor require precaution for concomitant use. If you take such medicines concomitantly with
GENVOYA Combination Tablets, side effects may occur or therapeutic effects may decrease.
Therefore, inform and consult with your healthcare providers (physician, pharmacist, etc.)
about all medicines that you are taking (including prescription medicines, over-the-counter
medicines, vitamins, herb supplements, and health foods) to take necessary measures.

Do not take GENVOYA Combination Tablets if you are taking the following
medicines (or medicines containing the following ingredients).
● Tuberculosis preparations● Pulmonary arterial hypertension agents· Rifampicin (Rifadin®, etc.)· Sildenafil citrate (Revatio®)· Tadalafil (Adcirca®)● Herbal products● Erectile dysfunction agents· St. John’s wort

· Vardenafil hydrochloride hydrate (Levitra®)● Migraine medications· Dihydroergotamine mesylate· Ergotamine tartrate (Cleamine®)● Calcium channel blockers● Oxytocics● Anticoagulants

How to take GENVOYA
Combination Tablets

Some medicines may not be administered concomitantly with GENVOYA Combination Tablets,

Effects of GENVOYA
Combination Tablets

Concomitant use of GENVOYA Combination Tablets withother medicines (1)· Asunaprevir (Sunvepra®)· Telaprevir (Telavic®)· Midazolam (Dormicum®, etc.)· Phenobarbital (Phenobal®, etc.)· Triazolam (Halcion®, etc.)● Hyperlipidemia agents● Antiepileptics· Lomitapide mesylate (Juxtapid®)· Simvastatin (Lipovas®, etc.)· Carbamazepine (Tegretol®, etc.)· Fosphenytoin (Fostoin®)· Phenytoin (Aleviatin®, etc.)● Antivirals● Psychotropics· Blonanserin (Lonasen®)· Pimozide (Orap®)● Therapeutic agent for hyperlipidemia· Lomitapide mesylate (Juxtapid®)

Do not take GENVOYA Combination Tablets if you are taking
the following anti-HIV medicines, etc.
Anti-HIV medicines: Viread®, Emtriva®, Truvada® Combination Tablets,
Complera® Combination Tablets, Descovy® Combination Tablets, Stribild® Combination Tablets,
Odefsey® Combination Tablets, BIKTARVY® Combination Tablets, Epzicom® Combination Tablets,
Combivir® Combination Tablets, Epivir®, Triumeq® Combination Tablets,
Kaletra® Combination Tablets, Norvir®, Prezcobix® Combination Tablets,
Symtuza® Combination Tablets
Anti-HBV (hepatitis B virus) medicines: Tenozet®, Vemlidy®, Zefix® Combination Tablets
Anti-HCV (hepatitis C virus) medicines: Viekirax® Combination Tablets
6

Side effects● Sedatives, hypnotics, and anxiolytics

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information· Rivaroxaban (Xarelto®)· Ergometrine maleate· Methylergometrine maleate (Methergin®, etc.)

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions· Azelnidipine (Calblock®, etc.)

Concomitant use of GENVOYA Combination Tablets withother medicines (2)Precautions need to be taken if you take the following medicines (or medicines containing
the following ingredients) concomitantly with GENVOYA Combination Tablets.
● Sedatives, hypnotics, and anxiolytics● Antiarrhythmic agents· Clorazepate dipotassium (Mendon®)· Diazepam (Cercine®, Horizon®, etc.)· Estazolam (Eurodin®, etc.)· Flurazepam hydrochloride (Dalmate®)· Zolpidem tartrate (Myslee®, etc.)· Amiodarone hydrochloride (Ancaron®, etc.)· Bepridil hydrochloride hydrate (Bepricor®)· Disopyramide (Rythmodan®, etc.)· Flecainide acetate (Tambocor®)· Mexiletine hydrochloride (Mexitil®, etc.)· Propafenone hydrochloride (Pronon®, etc.)· Quinidine sulfate hydrate (quinidine sulfate, etc.)● Antiepileptics· Clonazepam (Landsen®, Rivotril®)· Ethosuximide (Epileo petit mal®, etc.)● Diuretics● Psychotropics● Antihypertensives· Amitriptyline hydrochloride (Tryptanol®, etc.)· Imipramine hydrochloride (Imidol®, Tofranil®)· Nortriptyline hydrochloride (Noritren®)· Paroxetine hydrochloride hydrate (Paxil®, etc.)· Perphenazine (Trilafon®)· Quetiapine fumarate (Seroquel®, etc.)· Risperidone (Risperdal®, etc.)· Trazodone hydrochloride (Desyrel®, Reslin®, etc.)· Eplerenone (Selara®)· Metoprolol tartrate (Seloken®, Lopresor®, etc.)· Tolvaptan (Samsca®)● Migraine agents· Eletriptan hydrobromide (Relpax®)● Calcium channel blockers· Amlodipine besilate (Norvasc®, Amlodin®, etc.)· Diltiazem hydrochloride (Herbesser®, etc.)· Felodipine (Splendil®, etc.)· Nicardipine hydrochloride (Perdipine®, etc.)· Nifedipine (Adalat®, Sepamit®, etc.)· Verapamil hydrochloride (Vasolan®, etc.)● Local anesthetics· Lidocaine (Xylocaine®, etc.)● Glaucoma agents· Timolol maleate (Timoptol®, etc.)● Hyperlipidemia agents· Atorvastatin calcium hydrate (Lipitor®, etc.)● Otic and nasal agents· Fluticasone propionate [inhalant, intranasal](Flutide®, Flunase®, etc.)● Antitussives● Cardiotonics● Pulmonary arterial hypertension agents· Digoxin (Digosin®, etc.)· Bosentan hydrate (Tracleer®)· Dextromethorphan hydrobromide hydrate (Medicon®, etc.)7

Introduction /Table of contents● Miscellaneous metabolism agents● Antacids· Magnesium or aluminum-containing antacids(Maalox®, Milmag®, Alumigel®, etc.)· Ciclosporin (Sandimmun®, Neoral®, etc.)· Everolimus (Afinitor®, Certican®)· Tacrolimus hydrate (Prograf®, etc.)● Adrenal hormone preparations● Antineoplastics· Dexamethasone (Decadron®, etc.)· Dasatinib hydrate (Sprycel®)· Lapatinib tosilate hydrate (Tykerb®)· Temsirolimus (Torisel®)● Estrogen and progesterone preparations· Ethinylestradiol (Prosexol®)● Antibiotics· Clarithromycin (Clarith®, Klaricid®, etc.)· Itraconazole (Itrizole®, etc.)· Rifabutin (Mycobutin®)· Voriconazole (Vfend®, etc.)● Erectile dysfunction agents and dysuria agents· Sildenafil citrate (Viagra®, etc.)· Tadalafil (Cialis®, Zalutia®)● Overactive bladder agents● Antivirals· Tolterodine tartrate (Detrusitol®)· Aciclovir (Zovirax®, etc.)· Ganciclovir (Denosine®)· Valaciclovir hydrochloride (Valtrex®, etc.)· Valganciclovir hydrochloride (Valixa®)● Anticoagulants· Warfarin potassium (Warfarin®, etc.)

Effects of GENVOYA
Combination Tablets· Colchicine (colchicine)

How to take GENVOYA
Combination Tablets● Gout preparations· Budesonide (Pulmicort®)· Salmeterol xinafoate (Serevent®)

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions● Bronchodilators

Write down the medicines that you are currently taking.

Side effects*Including prescription medicines, over-the-counter medicines, vitamins, herbal supplements, health foods, etc.

If you do not know whether or not the medicine you areor pharmacist.
In addition, do not start taking any new medicine while
you are taking GENVOYA Combination Tablets without
asking your doctor or pharmacist first.

8

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

taking is included in this list, ask your prescribing doctor

What should you do if you miss a dose of
GENVOYA Combination Tablets?
The most important thing is to take measures toprevent missing a dose.
Not missing a dose is the most important course of action forcontinuously suppressing HIV activity. Make out a schedule fortaking GENVOYA Combination Tablets at a regular time in orderto ensure that you don’t forget.

Should you miss a dose of GENVOYA Combination Tablets…
If you miss a dose, take one dose of GENVOYA Combination Tablets (one tablet) as soon as possible
after you realize that you have forgotten to take the medicine. Subsequently, continue taking GENVOYA
Combination Tablets as scheduled.
If it is close to the time for the next administration when you realize that you have missed a dose, wait until
the next administration and take one dose as scheduled.

What you must not do if you miss taking a dose!
Never take two or more doses of GENVOYA
Combination Tablets (two or more tablets) at a time.
You should ask your healthcare provider (doctor or
pharmacist) in advance what to do if you forget totake GENVOYA Combination Tablets.

9

Introduction /Table of contents

Precaution for taking GENVOYA
Combination Tablets
hepatitis condition may relapse or rapidly deteriorate when you stop taking GENVOYA
Combination Tablets. Therefore, before starting the administration of GENVOYA Combination
Tablets, you need to check that you are not infected by HBV.

Hepatitis B virus (HBV)

Hepatitis B virus causes chronic hepatitis B. HBV continues to multiply inhepatocytes, but does not kill cells directly. Therefore, it must be notedthat even healthy people can be carriers of HBV. It is estimated that 1.5
million Japanese people are infected by HBV.

Side effects

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions

Notes

10

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

Note 4)

How to take GENVOYA
Combination Tablets

If you are infected by hepatitis B virus (HBV)4) and take GENVOYA Combination Tablets, yourEffects of GENVOYA
Combination Tablets

If you are infected by hepatitis B virus

What are the side effects of GENVOYA
Combination Tablets?
After the administration of GENVOYA Combination Tablets,
the following serious adverse effects may occur:
Recurrence or worsening of the hepatitis B described in “Precaution
for taking GENVOYA Combination Tablets” (page 10)
Changes in your immune system5)
Kidney problems6)
Bone problems7)
Lactic acidosis8)
Fatty liver or hepatomegaly9)

Note 5)

Changes in your immune system

After the rapid improvement in your immunity following the administration of anti-HIV medicines, you may feelabnormalities in your body as your immune system functions.

Note 6)

Kidney problems

Anti-HIV medicines may cause kidney problems. In clinical studies, GENVOYA Combination Tablets
had less of an impact on kidney lab test results than the comparator medicine, STRIBILD
Combination Tablets. However, GENVOYA Combination Tablets may cause additional kidney
problems, including kidney failure and dysfunction, or worsen existing kidney problems. Blood andurine tests are required both before and during administration of GENVOYA Combination Tablets.
Your doctor may tell you to stop taking GENVOYA Combination Tablets if your kidney function
worsens during administration of GENVOYA.

Note 7)

Bone problems

Bone problems may occur as a result of HIV infection or the effect of GENVOYA Combination
Tablets or other medicines. If you have a pre-existing bone disease(s), you may need to take abone density test, etc.

Note 8)Lactic acidosis

Lactic acidosis is a state of elevated blood lactate level. If you experience symptoms such as a severe feeling of weakness
or fatigue, severe muscle pain, or shortness of breath, immediately contact the hospital.

Note 9)Fatty liver or hepatomegalyThis is a condition in which fat accumulates in the liver, or the liver enlarges. If you experience symptoms such as yellowingof the skin or of the whites of your eyes, darkening of the color of your urine, or whitening of the color of your stool,
immediately contact the hospital.

11

Introduction /Table of contents

Have or have had any bone problems
Have any other medical conditions

The most common side effects
from taking GENVOYA Combination
Tablets are nausea, diarrhea,
headache, etc.

Although there are cases where you need to discontinue GENVOYA Combination Tablets due
to side effects, never discontinue the medicine or change how you take it based only on yourown judgment. If you notice any physical abnormalities, contact your hospital immediately.

How to take GENVOYA
Combination Tablets

Have or have had any kidney problems

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions

Have or have had any liver problems, including HBV infection

Effects of GENVOYA
Combination Tablets

Before administration of GENVOYA Combination Tablets, make sure
to tell your healthcare provider if any of the following apply to you.

12

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

Side effects

Notes

Taking GENVOYA Combination
Tablets during pregnancy?
Avoid taking GENVOYA during your pregnancy.
It has been reported that the blood concentrations ofactive ingredients contained in GENVOYA Combination
Tablets decline if taken during pregnancy.
If you are pregnant or plan to become pregnant, be sure
to tell your doctor before taking GENVOYA Combination
Tablets.

Breast-feeding
Avoid breast-feeding, since it may result in HIV being transmitted from mother to infant.
Emtricitabine contained in GENVOYA Combination Tablets may be excreted in milk. It is unknown whether
elvitegravir, cobicistat, and tenofovir alafenamide are excreted in milk. In addition, the effects of GENVOYA
Combination Tablets on the infant are unknown. Ask your doctor about meals for infants.

If you would like to know more about HIV infection, access:
AIDS Clinical Center, National Center for Global Health and Medicine
https://www.acc.go.jp/ (Japanese version only) (Viewed on September 10, 2021)
AIDS Medical Center, National Hospital Organization
Osaka National Hospital
https://osaka.hosp.go.jp/department/khac/center/(Japanese version only) (Viewed on September 10, 2021)

AIDS Prevention Information Networkhttps://api-net.jfap.or.jp/(Japanese version only) (Viewed on September 10, 2021)

13

Introduction /Table of contents

Is there anything else
you should know?

Do not give GENVOYA Combination Tablets to others.

Precautions in everyday life
Overseas research has demonstrated1-4 that HIV transmission to a sexual partner can beprevented* by taking effective treatment that persistently suppresses the HIV RNA content toless than 200 copies per milliliter of blood. However, it has not been proven that taking thetreatment will ensure complete prevention of HIV transmission.
The partner could be infected with sexually transmitted disease such as hepatitis B,
chlamydia, gonorrhea, and syphilis, or may have a type of HIV that does not respond as wellto the treatment. Thus, proper use of condoms is advised when engaging in sexual activities
in order to prevent becoming infected by such sexually transmitted diseases.
2: Rodger AJ, et al.: Lancet 2019; 393: 2428
4: HIV Treatment Guidelines, March 2021

What to do if you missa dose of GENVOYA
Combination Tablets /Precautions*Undetectable = Untransmittable; U = U
1: Rodger A, et al.: JAMA 2016; 316(2): 171
3: Bavinton BR, et al.: Lancet HIV 2018; 5(8): e438

How to take GENVOYA
Combination Tablets

Get regular examinations while taking GENVOYA Combination Tablets. Do not discontinue orchange how you take GENVOYA Combination Tablets based on your own judgment alone
without instructions from your doctor.

Effects of GENVOYA
Combination Tablets

Take note of the following points.

How to store GENVOYA Combination Tablets
Keep GENVOYA Combination Tablets out of the reach of children.
Keep GENVOYA Combination Tablets in its original container.
Store GENVOYA Combination Tablets at room temperature,away from moisture. Do not store GENVOYA Combination
Tablets at extremely high or low temperatures.
Be sure to close the cap of the container after taking out atablet for administration.

Desiccant

How to uncap the container of GENVOYA Combination Tablets
Follow the characteristic method for uncapping the container of
GENVOYA Combination Tablets.

1

Side effects

Leave the desiccant (photo on the right) in the container during storage.

2) Turn the cap to the left.

Citation: GENVOYA Full Prescribing Information (Issued: March 2016), Gilead Sciences, Inc.

14

Taking GENVOYA
Combination Tablets
during pregnancy /Additional information

21) While holding down the cap,

APPENDIX

Meals (1)
Meals are a source of everyday vigor and provide energy for maintaining the immune system. Delight brought
about by taking meals also refreshes your mind and body. Try to eat well-balanced food and live healthily.
Well-balanced food signifies having three meals regularly. Every time you eat, it is recommended to mind
the combination of staple foods (carbohydrates), the main dish (protein), and the sub-dish (vitamins,
minerals and dietary fiber).
* If you have a lifestyle-related disease or other complications, follow the instructions of healthcare providers.

Staple foods (carbohydrates)
Rice, bread, noodles, etc.

Sub-dish(vitamins, minerals and dietary fiber)

Main dish (protein)

Meat, fish, egg, soy beans, etc.

Vegetables, mushrooms, algae, etc.

For example, when you choose light food at a convenience store, it is well balanced to combine a staple
food (rice balls), the main dish (boiled egg), and the sub-dish (vegetable salad).

+Salmon rice ball

Energy: 369 kcal

= Fat: 14.4 g+
Boiled egg with salt

Lettuce salad

A makunouchi lunchbox or Chinese rice bowl also provides a staple food, the main dish and the sub-dishin good balance.

Staple food: rice
Main dish: squid, shrimp,
meat and egg
Sub-dish: Chinese cabbage,
carrot, etc.

Staple food: rice
Main dish: grilled fish and Japanesestyle rolled omelette
Sub-dish: stewed vegetables
Makunouchi lunchbox
Energy: 740 kcal; fat: 19.7 g

Chinese rice bowl
Energy: 841 kcal; fat: 28.9 g

15Balanced combination of ready-to-eat food products

Staple food

When you buy food products at a convenience store or a supermarket, select them keeping good balance in mind.

Salmon rice ball(120 g per piece)
Energy: 212 kcal; fat: 2.6 g

Bread and butter(60 g per slice)
Energy: 203 kcal; fat: 7.5 g

Spaghetti with tomato sauce(85 g of dried pasta)
Energy: 421 kcal; fat: 8.3 g

Udon noodles with hot soup(225 g of boiled udon)
Energy: 326 kcal; fat: 1.0 g

Main dish+Boiled egg with salt
(55 g per piece)
Energy: 83 kcal; fat: 5.7 g

Cold tofu(excluding soy sauce)
Energy: 116 kcal; fat: 6.0 g

Natto (fermented soybeans)with Chinese chives(40 g of natto)
Energy: 87 kcal; fat: 4.1 g

Salisbury steak(70 g of minced beef and pork)
Energy: 322 kcal; fat: 20.2 g

Processed cheese(18 g per piece)
Energy: 61 kcal; fat: 4.7 g

Ham and eggs
(55 g of egg)
Energy: 217 kcal; fat: 17.2 g

Deep-fried boneless chicken leg(80 g of boneless chicken leg with skin)
Energy: 263 kcal; fat: 17.0 g

Simmered mackerel with miso
(80 g of mackerel)
Energy: 200 kcal; fat: 9.9 g

Sub-dish+

Sautéed burdock root
(60 g of burdock)
Energy: 92 kcal; fat: 4.1 g

Spinach marinatedin sesame paste(80 g of spinach)
Energy: 53 kcal; fat: 2.8 g

Simmered kiriboshi-daikon(dried radish strips)(10 g of dried kiriboshi-daikon)
Energy: 126 kcal; fat: 5.8 g

Potato salad(110 g of potato)
Energy: 195 kcal; fat: 11.4 g

Braised pumpkin(90 g of pumpkin)
Energy: 113 kcal; fat: 0.3 g

Corn soup(50 g of canned corn)
Energy: 150 kcal; fat: 6.3 g

Lettuce salad(60 g of lettuce, including dressing)Energy: 74 kcal; fat: 6.1 gTonjiru (miso soup withpork and vegetables)(21 g of boneless pork rib)
Energy: 170 kcal; fat: 10.9 g

Sources: “Guide to Calories in Everyday Meals (Revised Version)” (Kagawa Nutrition University Publishing Division) and “Standard Tablesof Food Composition in Japan 2015 (Seventh Revised Version)” (Ministry of Education, Culture, Sports, Science and Technology)
It has been verified that the medicinal ingredients in GENVOYA® Combination Tablets are sufficiently absorbed into the body whentaken after the oral intake of ENSURE LIQUID® (energy: 250 kcal; fat: 8.8 g). Use this as a guide when selecting meal combinations.

16

APPENDIX

Meals (2)Supportive food when you cannot eat well(snacks, dietary supplements, beverages, etc.)●Energy and fat from snacks, dietary supplements and beverages

Foo

Energy400 kcalor higher

300 kcalor higher

Bread with tsubuan(sweet chunky red bean paste) &margarine (160 g per piece)
Energy: 610 kcal; fat: 29.4 g

Nissin Yakisoba U.F.O. (128 g per piece)[Nissin Foods]
Energy: 556 kcal; fat: 20.9 g
Assorted oden (fishcake and vegetable stew),
large cup (790 g, six ingredients)
Energy: 520 kcal; fat: 21.3 g

Nissin Cup Noodles(77 g per serving)[Nissin Foods]
Energy: 353 kcal;
fat: 15.2 g

Meiji Essel Super Cup
Super Vanilla (200 mL per piece)[Meiji]
Energy: 380 kcal; fat: 23.5 g
French toast (90 g per serving)
Energy: 358 kcal; fat: 14.9 g

200 kcalor higher

Mixed sandwiches (135 g per pack)
Energy: 354 kcal; fat: 21.0 g

Hamburger (108 g per piece)[McDonald’s]
Energy: 260 kcal; fat: 9.6 g
Cereal(40 g of cornflakes and
200 mL of milk)
Energy: 286 kcal; fat: 8.3 g

Cookies (60 g per piece)
Energy: 276 kcal; fat: 12.9 g

Dietary supplements

100 kcalor higher

Ippon Manzoku Bar
Cereal Chocolate (37 g per bar)
[Asahi Group Foods]
Energy: 195 kcal; fat: 11 g

Beverages
SOYJOY Blueberry (30 g per bar)[Otsuka Pharmaceutical]
Energy: 135 kcal; fat: 7.6 g

Balance Up Cream Genmai Bran
Blueberry(36 g for two pieces per pack)[Asahi Group Foods]
Energy: 176 kcal; fat: 9.3 g

Lower than
100 kcalBaumkuchen (60 g)
Energy: 252 kcal; fat: 15.3 g

Knorr® Cup Cream Corn Soup
(17.6 g per pack)[Ajinomoto]
Energy: 76 kcal; fat: 2.6 g

Mt.RAINIER caffe latte(240 mL per bottle)[Morinaga Milk]
Energy: 166 kcal;
fat: 7.2 g
Whole milk (200 mL)
Energy: 134 kcal;
fat: 7.6 g

Milk tea(200 mL, milk:tea = 1:1, without sugar)
Energy: 71 kcal; fat: 4.0 g

Sources: “Guide to Calories in Everyday Meals (Revised Version)” (Kagawa Nutrition University Publishing Division) and “Standard Tables of Food Composition in Japan 20
It has been verified that the medicinal ingredients of GENVOYA® Combination Tablets are sufficiently abs

17

It is desirable to eat well-balanced meals.
If it is difficult to eat adequately, try to add snacks, dietary supplements, beverages, etc.

odAlmond Chocolate(88 g per box)
[Meiji]
Energy: 500 kcal;
fat: 33.6 g

Nutritionally balanced foodCalorie Mate BLOCK Cheese(80 g, 4 blocks)[Otsuka Pharmaceutical]
Energy: 400 kcal; fat: 22.2 g
Castella cake (135 g)
Energy: 424 kcal; fat: 6.1 g

Fried chicken (100 g per piece)
Energy: 340 kcal; fat: 22.6 g

Nikuman (steamed
pork bun)(100 g per piece)
Energy: 251 kcal;
fat: 4.4 g

Half-melon shaped bun (100 g per piece)
Energy: 402 kcal; fat: 9.3 g

Curry bread (105 g per piece)
Energy: 330 kcal; fat: 17.3 g

Cream bun (105 g per piece)
Energy: 320 kcal; fat: 11.4 g

Cream puff (100 g per piece)
Energy: 303 kcal; fat: 19.7 g

Nutritionallybalanced foodCalorie MateApple Jelly(215 g per pack)[Otsuka Pharmaceutical]
Energy: 200 kcal;
fat: 4.4 g

Dorayaki (bean-jam pancake)(80 g per piece)
Energy: 218 kcal; fat: 1.2 g
Doughnut (50 g per piece)
Energy: 226 kcal; fat: 11.7 g

Caramel pudding (125 g per piece)
Energy: 208 kcal; fat: 13.4 g

Fruit

Meiji Bulgaria Nomu Yogurt
LB81 Plain (200 g per pack)[Meiji]
Energy: 134 kcal; fat: 1.0 g
Milk cocoa(with 12 g of sugar)
Energy: 203 kcal;
fat: 9.3 g

Yasaiseikatsu 100 Original(200 mL per pack)[Kagome]Energy: 64 kcal; fat: 0 g

Processed soy milk
(200 mL)
Energy: 128 kcal;
fat: 7.2 g

Apple(150 g of half an unpeeled apple)
Energy: 92 kcal; fat: 0.5 g

Banana (120 g)
Energy: 103 kcal;
fat: 0.2 g

Pineapple(150 g of cut pineapple)
Energy: 77 kcal; fat: 0.15 g

Yogurt with jam(130 g of yogurt(whole fat, sugarless))
Energy: 100 kcal;
fat: 3.9 g

Mandarin orange(140 g of unpeeled mandarin orange)
Energy: 64 kcal; fat: 0.1 g

015 (Seventh Revised Version)” (Ministry of Education, Culture, Sports, Science and Technology); and the respective websites of each product (accessed December 2018)
sorbed into the body when taken after the oral intake of ENSURE LIQUID® (energy: 250 kcal; fat: 8.8 g). Use this as a guide when selecting meal combinations.

18

Contact Information

Gilead Sciences, Inc.
Gran Tokyo South Tower, 1-9-2 Marunouchi, Chiyoda-ku, Tokyo, 100-6616〈英語版〉
GEN21DS0125PA Created in November 2021