September 20th, 20082009 Prohibited List
Summary of Major Modifications and Clarifications
INTRODUCTORY PARAGRAPH•Article 4.2.2 of the 2009 Code states: “For purposes of the application ofArticle 10 (Sanctions on Individuals) all Prohibited Substances shall be‘Specified Substances’ except substances in the classes of anabolic
agents and hormones and those stimulants and hormone antagonists
and modulators so identified on the Prohibited List. Prohibited Methods
shall not be Specified Substances”
To reflect these changes in the Code, the following sentence has been
added: “All Prohibited Substances shall be considered as “SpecifiedSubstances” except Substances in classes S1, S2, S4.4 and S6.a, andProhibited Methods M1, M2 and M3.”

SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND
OUT-OF-COMPETITION)
S1. Anabolic Agents
1- Anabolic Androgenic steroids•

The nomenclature of prostanozol has been changed to 17β-hydroxy-5αandrostano[3,2-c] pyrazole to better follow the International Union ofPure and Applied Chemistry (IUPAC) rules.

•Epitestosterone has been moved from section S5 (Diuretics and otherMasking Agents) to S1 (Anabolic Agents, Endogenous Anabolic
Androgenic Agents) since it is an isomer of testosterone. This way,
epitestosterone will maintain its status as a non-specified substance forsanction purposes.

•The detailed explanation on the management of atypical endogenous
AAS results has been converted into a comment in accordance with theformat of the World Anti-Doping Code.

1S2. Hormones and Related Substances•

In order to reflect the heterogeneity of new EPO-like substances indevelopment, “Erythropoietin” has been replaced by “ErythropoiesisStimulating Agents”.

•LH, CG clearly named as the Gonadotrophins which are prohibited inmales.

•The explanatory note at the end of this section has been converted into
a comment in accordance with the format of the World Anti-Doping
Code.

S3. Beta-2 Agonists•

In compliance with the 2009 Code, references to Abbreviated TUEs havebeen removed.

•

Inhaled formoterol, salbutamol, salmeterol and terbutaline require a
Therapeutic Use Exemption in accordance with the new International
Standard for Therapeutic Use Exemptions.

•The presence of salbutamol in urine in excess of 1000 ng/mL will beconsidered an Adverse Analytical Finding unless the Athlete proves,through a controlled pharmacokinetic study, that the abnormal result
was the consequence of the use of a therapeutic dose of inhaledsalbutamol. A controlled pharmacokinetic study must be conducted in a
hospital environment or a reference center for the medical condition
concerned, where the administered dose(s) can be rigorously monitored
and the quality of the analysis documented.

S5. Diuretics and Other masking Agents•

As explained above, epitestosterone has been moved to section S1.

•Alpha reductase inhibitors are no longer prohibited. They have been
rendered ineffective as masking agents by closer consideration of steroid
profiles.

•The word “intravenous administration” now precedes the examples ofplasma expanders albumin, dextran, hydroxyethyl starch, to reflect thatthese substances are only prohibited when administered by this route;mannitol has been added as an example. Mannitol by inhalation ispermitted e.g. to perform bronchial provocation testing in asthma.

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It is stated that the carbonic anhydrase inhibitors dorzolamide andbrinzolamide, when administered topically in the eye, are not prohibited.
The rationale behind this exception is these drugs do not have a diuretic
effect when topically applied.

PROHIBITED METHODS
M2. Chemical and Physical Manipulation•Intravenous infusions are prohibited and thus require a Therapeutic Use
Exemption except in the management of surgical procedures, medical
emergencies or clinical investigations.
The intent of this section is to prohibit hemodilution, overhydration andthe administration of prohibited substances by means of intravenous
infusion. An intravenous infusion is defined as the delivery of fluids
through a vein using a needle or similar device.
The legitimate medical uses of intravenous infusions that follow are notprohibited:
1.
Emergency intervention including resuscitation;
2.
Blood replacement as a consequence of blood loss;
3.
Surgical procedures;
4.
Administration of drugs and fluids when other routes ofadministration are not available (e.g. intractable vomiting)in accordance with good medical practice, exclusive ofexercise induced dehydration.
Injections with a simple syringe are not prohibited as a method if theinjected substance is not prohibited and if the volume does not exceed
50 mL.

M3. Gene Doping•

The definition of Gene Doping has been reworded in order to reflect newtechnologies in this field.

•Peroxisome Proliferator Activated Receptor δ and AMP-activated protein
kinase axis agonists have been added based on recent scientific data.

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SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION
S6. Stimulants• Based on the article 4.2.2 of the revised Code the List Committee
addressed all stimulants named in the 2008 Prohibited List and categorized
them as specified or non-specified. The ability to enhance performance insports, the risk to health, general use in medicinal products, legitimate
market availability, their illicit use, legal/controlled status, history andpotential of abuse in sports, their metabolism into amphetamine and/ormetamphetamine, the likelihood of approval for Therapeutic Use
Exemptions, and their pharmacology were taken into consideration. All thenon-specified stimulants are named in section S6.a, while a list of examplesof specified stimulants are included in section S6.b.
• Before considering the reintroduction of pseudoephedrine it was foundthat more information is needed and a research project is initiated to thateffect. As for now, pseudoephedrine remains in the Monitoring Program.
S9. Glucocorticosteroids•

In compliance with the 2009 Code, references to Abbreviated TUEs havebeen removed.

•In accordance with the International Standard for Therapeutic Use
Exemptions, a declaration of use must be completed by the Athlete forthe administration of glucocorticosteroids by intraarticular, periarticular,perintendinous, epidural, intradermal and inhalation routes.

•No TUE or declaration of use is required for topical administration ofglucocorticosteroids

SUBSTANCES PROHIBITED IN PARTICULAR SPORTS
P1. Alcohol•The doping violation threshold for blood and breath alcohol (ethanol) hasbeen harmonized for all International Federations to 0.1 g/L.

•

At the request of the Federation International de Quilleurs (FIQ), Ninepin
Bowling is included. WADA List Committee also included Tenpin bowlingsince this discipline is also part of FIQ.

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P2. Beta-blockers•

At the request of the Federation International de Quilleurs (FIQ), thespelling of Ninepin Bowling is corrected. WADA List Committee alsoincluded Tenpin bowling in this category since this discipline is also partof FIQ.

•At the request of the International Golf Federation, beta-blockers are
now prohibited in golf.

SPECIFIED SUBSTANCES•This section is deleted, as the definition of Specified Substances haschanged under the revised Code. The new division between Specifiedand Non-specified Substances is now included in the Introductory
Paragraph.

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