The 57th Japanese Peptide Symposium
November 9 (Monday)
10:00-10:10

Opening Remarks (Tsuyoshi Kawano)

10:10−11:06

Young Investigator’s Oral Presentations (9 min talk, 5 min discussion &exchange)
Section 1 (chairs: Yoshiaki Yano, Yuichi Masuda)

Y-01

Iridium-catalyzed proline-selective carbonyl modification
11

1

2

1

Tatsuya Mori , Yoshito Takahashi , Risa Yoshii , Takeshi Oishi , Takaaki Sato ,1 12
Noritaka Chida ( Faculty of Science and Technology, Keio University, School ofMedicine, Keio University)
Y-02

Development of solid-supported 4-fluorophenyl 3-nitro-2-pyridinesulfenate (NpysOPh(pF)) as an efficient disulfide-forming agent
Yan Cui, Akihiro Taguchi, Kiyotaka Kobayashi, Hayate Shida, Kentaro Takayama,Atsuhiko Taniguchi, Yoshio Hayashi (Department of Medicinal Chemistry, Tokyo
University of Pharmacy and Life Sciences)

Y-03

Total synthesis of hytramycin V, a cyclic peptide antibiotic
Tetsuya Inaba, Masahito Yoshida, Hideo Kigoshi (Graduate School of Pure andApplied Sciences, University of Tsukuba)

Y-04

De novo design of a-helix peptides for construction of artificial transmembrane pores
Masataka Usami, Ryuji Kawano (Department of Biotechnology and Life Science,
Tokyo University of Agriculture and Technology)

11:06−11:20 Break
11:20−12:16

Y-05

Young Investigator’s Oral Presentations (9 min talk, 5 min discussion &exchange)
Section 2 (chairs: Kentaro Takayama, Yuji Yamada)Electrophysiological analysis of cell-penetrating peptides with planar lipid bilayer
systemChihiro Saito, Yuri Numaguchi, Ryuji Kawano (Department of Life Science andBiotechnology, Tokyo University of Agriculture and Technology)

Y-06

Evaluation of channel-forming activity and inhibition of Ab42 using nervous cellmembrane imitated lipid bilayer device
11

1

2

Yuri Numaguchi , Keisuke Shimizu , Kaori Tsukakoshi , Yuki Suzuki , Kazunori
1

1

1Ikebukuro , Ryuji Kawano ( Department of Life Science and Biotechnology,
2
Tokyo University of Agriculture and Technology, Frontier Research Institute forInterdisciplinary Sciences, Tohoku University)
Y-07

Extracellular thiol-disulfide exchange reaction produces potent macropinocytosisinducing peptide analogs
Jan Vincent V. Arafiles, Hisaaki Hirose, Shiroh Futaki (Institute for ChemicalResearch, Kyoto University)

Y-08

Artificial viral capsid to deliver biomacromolecules into cytosol
122

1Kentarou Sakamoto , Hiroto Furukawa , Kazunori Matsuura , Shiroh Futaki12( Institute for Chemical Research, Kyoto University, Graduate School ofEngineering, Tottori University)
12:16−12:30

Break

12:30−13:30

Lunch Break & Online Seminar

13:30−14:00

Break & Poster Checking

14:00−15:00
15:00−16:00

Poster Presentation 1 (P-001〜P-026)
Poster Presentation 2 (P-027〜P-052)

16:00−16:20

Break

16:20−17:16

Young Investigator’s Oral Presentations (9 min talk, 5 min discussion &exchange)
Section 3 (chairs: Takuyuki Miki, Chie Kojima)

Y-09

Immunological evaluation of conjugate/co-assembly of peptide antigen and adjuvant
as self-adjuvanting anti-breast cancer vaccine candidates
11,211

Keita Ito , Yoshiyuki Manabe , Taku Aiga , Tsung-Che Chang , Kazuya
1,23
3
44
Kabayama , Shino Ohshima , Yoshie Kametani , Hiroto Furukawa , Hiroshi Inaba ,41,21Kazunori Matsuura , Koichi Fukase ( Graduate School of Science, Osaka
2University, Project Research Center for Fundamental Sciences, Osaka University,
34
School of Medicine, Tokai University, Graduate School of Engineering, TottoriUniversity)

Y-10

Investigation of the immunogenicity of mirror-image single-domain antibody
1211

1,3

Keisuke Aoki , Motohiro Nonaka , Shinsuke Inuki , Hiroaki Ohno , Shinya Oishi
12( Graduate School of Pharmaceutical Sciences, Kyoto University, Graduate School
3of Medicine, Kyoto University, Department of Medicinal Chemistry, Kyoto
Pharmaceutical University)
Y-11

Changes in structure and stability of p53 family tetramerization domain in vertebrate
evolution
11

1,2

2Shuya Sakaguchi , Natsumi Nakagawa , Rui Kamada , James G. Omichinski ,1,2
1Kazuyasu Sakaguchi ( Laboratory of Biological Chemistry, Department of2Chemistry, Faculty of Science, Hokkaido University, Laboratory of BiologicalChemistry, Graduate School of Chemical Sciences and Engineering, Hokkaido
3University, Department of Biochemistry and Molecular Medicine, University ofMontreal)
Y-12

Development of a-dystroglycan binding peptide modified liposomes for muscle
targeting delivery system
Eri Sasaki, Yuka Kimura, Nobuhito Hamano, Kei Nirasawa, Keisuke Hamada,
Yamato Kikkawa, Tsuyoshi Miura, Yoko Endo-Takahashi, Motoyoshi Nomizu,
Yoichi Negishi (School of Pharmacy, Tokyo University of Pharmacy and LifeSciences)

17:16−17:30

Break17:30−18:26

Young Investigator’s Oral Presentations (9 min talk, 5 min discussion &exchange)
Section 4 (chairs: Yuki Goto, Tetsuo Narumi)

Y-13

Exploratory studies on the development of anti-HIV-1 peptides based on HIV-1 capsid
fragments
111

1

Kofi Baffour-Awuah Owusu , Kohei Tsuji , Rongyi Wang , Takuya Kobayakawa ,12
1
1
Moemi Kaneko , Tsutomu Murakami , Hirokazu Tamamura ( Institute ofBiomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU),
2AIDS Research Center, National Institute of Infectious Diseases)

Y-14A new thiol additive for one-pot sequential peptide ligation-desulfurization chemistry1112

Kento Ohkawachi , Daishiro Kobayashi , Kyohei Morimoto , Akira Shigenaga ,1331 1
Masaya Denda , Kenzo Yamatsugu , Motomu Kanai , Akira Otaka ( Institute ofBiomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima
2University, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama
3University, Graduate School of Pharmaceutical Sciences, The University ofTokyo)
Y-15

Development of antimicrobial peptide foldamers based on Magainin 2 sequence
1,21,221,2Motoharu Hirano , Chihiro Goto , Takashi Misawa , Yosuke Demizu
12( Graduate School of Medical Life Sciences, Yokohama City University, National
Institute of Health Sciences)
Y-16

The use of cysteinylprolyl imide peptide as an Fmoc-compatible crypto-thioester
1

1

2

1,3

Koki Nakatsu , Masafumi Yanase , Gosuke Hayashi , Akimitsu Okamoto1( Department of Chemistry and Biotechnology, The University of Tokyo,
2
Department of Biomolecular Engineering, Graduate School of Engineering,3
Nagoya University, Research Center for Advanced Science and Technology, TheUniversity of Tokyo)
18:26−18:40

Break

18:40−19:10

Invite Lecture (I)IL-01(chairs: Tsuyoshi Kawano, Kazunori Matsuura)

Neuropeptides, receptors, and their biological roles in the sister group ofvertebrates, Ciona intestinnalis Type A
Honoo Satake (Bioorganic Research Institute, Suntory Foundation for Life Sciences)

November 10 (Tuesday)
10:00−11:06

O-01

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 1 (O-01−03) (chairs: Toru Kawakami, Yoshio Hayashi)

Chemical synthesis of ubiquitin derivatives containing non-canonical unit
1,2,32

12

Kohei Sato , Yoshinori Taguchi , Takuma Nishizawa , Sayuri Takeo , Shoko
3
1,2,3
1,2,31
Tanaka , Nobuyuki Mase , Tetsuo Narumi( Department of Engineering,Graduate School of Integrated Science and Technology, Shizuoka University,
2

3

Faculty of Engineering, Shizuoka University, Graduate School of Science andTechnology, Shizuoka University)
O-02

Density functional theory (DFT)-based insights into reaction mechanism of phosphatecatalyzed N-S acyl transfer of N-sulfanylethylanilide (SEAlide)
Akira Shigenaga (Faculty of Pharmacy and Pharmaceutical Sciences, FukuyamaUniversity)

O-03

Structure-activity relationship study on macrocyclic bace1 inhibitors containing ahydrophobic cross-linked structure
112

11

Kazuya Kobayashi , Takuya Otani , Yasunao Hattori , Kenichi Akaji ( Department
2of Medicinal Chemistry, Kyoto Pharmaceutical University, Center for Instrumental
Analysis, Kyoto Pharmaceutical University)
11:06−11:25

Break

11:25−12:09

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 2 (O-04−05) (chairs: Akira Otaka, Hironobu Hojo)

O-04

Noncovalent interactions in the chloroalkene-type RGG peptidomimetics stabilize thebeta-turn structure
1,2,32113

Tetsuo Narumi , Yuki Kodama , Yuna Kato , Kosuke Arai , Sayuri Takeo ,4
1,2,3
1,2,3
4Tatsuki Masuzawa , Kohei Sato , Nobuyuki Mase , Takanori Oyoshi
1( Department of Engineering, Graduate School of Integrated Science and2Technology, Shizuoka University, Graduate School of Science and Technology,
3
4Shizuoka University, Faculty of Engineering, Shizuoka University, Department ofScience, Graduate School of Integrated Science and Technology, ShizuokaUniversity)

O-05

Interplay between amino acid sequences and lipid compositions in the GXXXGmediated self-association of transmembrane helices as revealed by single-pair FRET
Yoshiaki Yano, Takayuki Morise, Katsumi Matsuzaki (Graduate School of
Pharmaceutical Sciences, Kyoto University)

12:09−12:30

Break

12:30−13:30

Lunch Break & Online Seminar

13:30−14:00

Break & Poster Checking

14:00−15:00
15:00−16:00

Poster Presentation 3 (P-053〜P-078)
Poster Presentation 4 (P-079〜P-103)

16:00−16:20

Break

16:20−17:26

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 3 (O-06−08) (chairs: Hidehito Mukai, Ikuhiko Nakase)

O-06

Lysosomal enzyme replacement therapy using H16 peptide
Takashi Iwasaki, Taiki Hayashi, Nodoka Murakami, Tsuyoshi Kawano (Graduate
School of Sustainability Science, Tottori University)

O-07

Endogenous protein expression imaging by fluorogenic ZIP tag-probe system
1,222

Wataru Nomura , Takumi Kamimura , Takuya Kobayakawa , Hirokazu
21
Tamamura ( Graduate School of Biomedical and Health Sciences, Hiroshima
2University, Institute of Biomaterials and Bioengineering, Tokyo Medical andDental University (TMDU))
O-08

Development of bivalent inhibitors of polo-like kinase 1 with great affinity
enhancement
1,22

3

3

1Kohei Tsuji , David Hyme , Buyong Ma , Ruth Nussinov , Hirokazu Tamamura ,21
Terrence R. Burke, Jr. ( Institute of Biomaterials and Bioengineering, Tokyo
2
Medical and Dental University (TMDU), Chemical Biology Laboratory, Center for
3Cancer Research, National Cancer Institute, National Institutes of Health, Cancer
and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National
Laboratory for Cancer Research, National Cancer Institute at Frederick)
17:26−17:35

Break17:35−18:19

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 4 (O-09−10) (chairs: Motoyoshi Nomizu, Kazuyasu Sakaguchi)

O-09

Development of de novo peptides for construction of artificial protein condensates inintracellular space
Takayuki Miki, Taichi Nakai, Keigo Kajiwara, Hiroki Takahashi, Masahiro
Hashimoto, Hiroshi Tsutsumi, Hisakazu Mihara (School of Life Science andTechnology, Tokyo Institute of Technology)

O-10

Structural modification of microtubules by encapsulation of proteins using a tauderived peptide
112

3Hiroshi Inaba , Takahisa Yamamoto , Takashi Iwasaki , Arif Md. Rashedul Kabir ,33
1
1Akira Kakugo , Kazuki Sada , Kazunori Matsuura ( Graduate School of
2Engineering, Tottori University, Graduate School of Agricultural Sciences, Tottori
3University, Graduate School of Science, Hokkaido University)
18:19−18:30

Break

18:30−19:00

Invite Lecture (II) (chairs: Kazunori Matsuura, Tsuyoshi Kawano)

IL-02

Chemical modification of endogenous proteins in living systems
Itaru Hamachi (Department of Synthetic Chemistry and Biological Chemistry,
Graduate School of Engineering, Kyoto University)

19:00−19:30
IL-03

Invite Lecture (III) (chairs: Kazunori Matsuura, Tsuyoshi Kawano)

Peptide bionanodesign: Old forms for new functions
Max Ryadnov (Biometrology research area, National Physical Laboratory, UK)November 11 (Wednesday)
10:00−11:06

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 5 (O-11−13) (chairs: Shiroh Futaki, Hisakazu Mihara)

O-11

Three-dimensional cell culture using laminin peptide-conjugated agarose microgels
Yuji Yamada, Chihiro Yoshida, Keisuke Hamada, Yamato Kikkawa, Motoyoshi
Nomizu (School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)

O-12

Curvature-sensing peptides to distinguish bacterial extracellular membrane vesicles
from cells in cultured medium
1222Kenichi Kawano , Fumiaki Yokoyama , Jun Kawamoto , Takuya Ogawa , Tatsuo
21 1
Kurihara , Shiroh Futaki ( Laboratory of Biofunctional Design Chemistry, Institute2for Chemical Research, Kyoto University, Laboratory of Molecular Microbial
Science, Institute for Chemical Research, Kyoto University)
O-13

Immune-stimulatory helix–loop–helix peptide: selective inhibition of CTLA-4–B7
interaction
12

Daisuke Fujiwara , Tharanga M. R. Ramanayake Mudiyanselage , Masataka113
2
1Michigami , Zhengmao Ye , Norimitsu Inoue , Kikuya Sugiura , Ikuo Fujii
12( Graduate School of Science, Osaka Prefecture University, Graduate School of
3Life and Environmental Sciences, Osaka Prefecture University, Department ofTumor Immunology, Osaka International Cancer Institute)
11:06−11:25 Break
11:25−12:09

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 6 (O-14−15) (chairs: Ikuo Fujii, Ayami Matsushima)

O-14

Development of small affinity peptide ligands for human antibody purification
Abdur Rafique, Yuji Ito (Graduate School of Science and Engineering, Kagoshima
University)

O-15

Site-specific covalent conjugation of IgG antibodies by CCAP method using Z33
affinity peptide: its application for drug and diagnostic reagent
1,32

2

1

1

Satoka Mori , Yukinari Kato , Mika K. Kaneko , Abdur Rafique , Yuji Ito
12( Graduate School of Science and Engineering, Kagoshima University, Graduate
3
School of Medicine, Tohoku University, Denka Innovation Center)
12:09−12:30

Break13:30−13:50

Lunch Break & Online Seminar

13:50−14:56

Oral Presentations (15 min talk, 7 min discussion & exchange)
Section 7 (O-16−18) (chairs: Hirokazu Tamamura, Takaki Koide)

O-16

Pharmacokinetic control of cyclosporine A employing polymeric nanocarriers
designed by flash nanoprecipitation
11

2

2

3

Hideyuki Sato , Yuuki Kaneko , Kurt D Ristroph , Hoang D Lu , Hak-Kim Chan ,21
1Robert K Prud’homme , Kohei Yamada1, Satomi Onoue ( Laboratory ofBiopharmacy, School of Pharmaceutical Sciences, University of Shizuoka,
23O-17

Department of Chemical & Biological Engineering, Princeton University,Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney)

Investigation of the thioflavin-T binding mechanism using a peptide self-assembly
mimicking protein
12

1

1

1

Sae Namioka , Norio Yoshida , Hiroyuki Konno , Koki Makabe ( Graduate School
2of Science and Engineering, Yamagata University, Department of Chemistry,
Graduate School of Science, Kyushu University)
O-18

Detection of ligand-protein interactions using reactive peptide and/or intein tags
capable of activating reporter enzymes
Tsuyoshi Takahashi, Hiroaki Hagiwara (Graduate School of Science andTechnology, Gunma University)

14:56−15:10

Break

15:10−16:10

Lectures of the Young Investigator Award(chairs: Yoshio Hayashi, Hisakazu Mihara)

AL-01 Development of new peptide synthetic methodology based on disulfide bondformation: revival of Npys chemistry
Akihiro Taguchi (Tokyo University of Pharmacy and Life Sciences)
AL-02 Construction of functional soft materials using phage-displayed peptides
Toshiki Sawada (Tokyo Institute of Technology)
16:10−16:20

Closing Remarks (Kazunori Matsuura)