Q&A
2010 Prohibited List

What major changes does the 2010 List of Prohibited Substances and Methods
include compared to the 2009 List?
The List reflects the latest scientific advances.

Several of the changes to be implemented in 2010 will allow anti-doping
organizations to manage a number of substances and methods in a significantly
more administrative- and cost-effective way. In particular:
Salbutamolo

Following several years of practice and consideration of all relevant
information from stakeholders and others, WADA’s List Committee
recommended a change for the status of the beta-2 agonist salbutamol – asubstance listed as a specified substance in the 2009 List.

oOver the past few years, almost all cases where salbutamol has been
detected were covered by Therapeutic Use Exemptions (TUEs).

oIn the 2010 List, therapeutic use of inhaled salbutamol will not be prohibited
and will therefore no longer require a TUE. For monitoring purposes, athletes
using inhaled salbutamol will be required to declare their use on the Doping
Control Form when they are tested.

oSalbutamol will still be prohibited for urinary concentrations above 1,000nanograms per millilitre. In such cases, there will be a presumption that thesubstance was not taken by inhalation and the athlete will have the burden to
demonstrate through a controlled pharmacokinetic study that the level foundin his urine was the result of therapeutic inhaled use.

Anabolic Steroids
oThe detailed technical comments on the management of analytical results
related to anabolic agents have now been moved to the revised WADA
Technical Document on Minimum Required Performance Levels for Detectionof Prohibited Substances. No further collections or analyses will be required incases where the testosterone to epitestosterone (T/E) ratio is greater than 4
and an isotope ratio mass spectrometry (IRMS) test or any other reliable
analytical method has not revealed evidence of exogenous administration of aprohibited substance.
1What other noteworthy changes does the 2010 List include?
PseudoephedrinePseudoephedrine will be reintroduced to the List.

Until 2003, pseudoephedrine was prohibited in sport. It has been included in WADA’s
Monitoring Program annually from 2004 on. (The Monitoring Program includes
substances that are not prohibited in sport but are monitored by anti-doping
laboratories in order to detect patterns of misuse.)

Results of the Monitoring Program over the past five years have shown a sustained
increase in samples containing pseudoephedrine. The Program indicated clear abuseof this substance with high concentrations in a number of sports and regions. In
addition, available literature shows scientific evidence of the performance-enhancing
effects of pseudoephedrine beyond certain doses.

Based on the results of the Monitoring Program, as well as scientific literature andresults of controlled excretion studies conducted by WADA, pseudoephedrine will be
prohibited above 150 micrograms per millilitre.

OxygenThe 2010 List clarifies that supplemental oxygen (hyperoxia) is not prohibited.

Platelet-Derived Preparations
The status of platelet-derived preparations (e.g. Platelet Rich Plasma, “bloodspinning”) has been clarified. These preparations will be prohibited whenadministered by intramuscular route. Other routes of administration will require adeclaration of use in compliance with the International Standard for TUEs.

What is the status of sildenafil (Viagra)?
Sildenafil (Viagra) is not on the List.

WADA is aware of studies presented in relation to the potential of sildenafil to restore
pulmonary capacities at very high altitudes. WADA is funding a number of research
projects on the effects of sildenafil at various altitudes. These projects are ongoing.

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