Product safety information sheet
according to REACH (article 32)

Fragment Buffer L
Printing: 13/04/2022

Date of compilation: 24/01/2022

Version: 1

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Fragment Buffer L

Other means of identification:
VLF, LFB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1064,6 kg/m³

Relative density at 20 ºC:

1,065

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Fragment Buffer S

Other means of identification:
SFB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1064,5 kg/m³

Relative density at 20 ºC:

1,064

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Library Beads

Other means of identification:
LIB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1043 kg/m³

Relative density at 20 ºC:

1,043

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Non-applicable *Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Library Solution

Other means of identification:
LIS
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

Precautions for safe handling:- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1041,9 kg/m³

Relative density at 20 ºC:

1,042

Dynamic viscosity at 20 ºC:

1,08 cP

Kinematic viscosity at 20 ºC:

1,03 mm²/s

Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Non-applicable *Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:

Ligation Adapter

Other means of identification:
LA
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet- CONTINUED ON NEXT PAGE -Printing: 30/05/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1143,9 kg/m³

Relative density at 20 ºC:

1,144

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Non-applicable *Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:

Ligation Buffer

Other means of identification:
LNB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1033,7 kg/m³

Relative density at 20 ºC:

1,034

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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Sequencing Buffer / RNA Running Buffer
Printing: 24/06/2022

Date of compilation: 14/03/2022

Revised: 08/04/2022

Version: 2 (Replaced 1)

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Sequencing Buffer / RNA Running Buffer

Other means of identification:
SQB, RRB, SB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS **3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006** Changes with regards to the previous version

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
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1)

Date of compilation: 14/03/2022

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SECTION 4: FIRST AID MEASURES (continued)
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

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SECTION 7: HANDLING AND STORAGE
7.1

Precautions for safe handling:
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2

7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1105,7 kg/m³

Relative density at 20 ºC:

1,106

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 24/06/2022
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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Version: 2 (Replaced 1)

SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description

Waste class (Regulation (EU) No
1357/2014)

discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 24/06/2022
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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 24/06/2022
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Version: 2 (Replaced 1)

SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
COMPOSITION/INFORMATION ON INGREDIENTS (SECTION 3):· Removed substances
Adenosine 5´-triphosphate (56-65-5)
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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Version: 1

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:

AMPure XP Beads / SPRI Beads

Other means of identification:
VXP, AXP, SPRI
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

E.- Body protection- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1032,6 kg/m³

Relative density at 20 ºC:

1,033

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 13/04/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:DNA / RNA CS

Other means of identification:
DCS, RCS, DNACS
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1032,2 kg/m³

Relative density at 20 ºC:

1,032

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Elution Buffer

Other means of identification:
VEB, EB
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety data Sheet- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammabliity characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks. Keep containers hermetically sealed. Control
spills and residues, destroying them with safe methods (section 6). Avoid leakages from the container. Maintain order andcleanliness where dangerous products are used.
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1034 kg/m³

Relative density at 20 ºC:

1,034

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO2), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 13/04/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:

Flow Cell FlushOther means of identification:
FCF
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Colourless

Odour:

OdourlessOdour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1068,5 kg/m³

Relative density at 20 ºC:

1,068

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Non-applicable *Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1

Product identifier:Flowcell (Flush) Tether / Priming Tether

Other means of identification:
FLT, PT, FT, FCT
1.2

Relevant identified uses of the substance or mixture and uses advised against:
Relevant uses: Research use
Uses advised against: All uses not specified in this section or in section 7.3

1.3

Details of the supplier of the safety data sheet:

1.4

Oxford Nanopore Technologies
Gosling Building, Edmund Halley Road, Oxford Science ParkOX4 4DQ Oxford - Oxon - England
Phone: +44 (0)845 034 7900 - Fax: +44 (0)845 034 7901
http://www.nanoporetech.com/
Emergency telephone number: +44 (0)845 034 7900 (9am-5:30pm GMT)SECTION 2: HAZARDS IDENTIFICATION
2.1

Classification of the substance or mixture:
CLP Regulation (EC) No 1272/2008:
The product is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

2.2

Label elements:
CLP Regulation (EC) No 1272/2008:
Hazard statements:
Non-applicable
Precautionary statements:

2.3

P101: If medical advice is needed, have product container or label at hand.
P102: Keep out of reach of children.
P501: Dispose of contents/container according to the separated collection system used in your municipality.
Other hazards:
Product fails to meet PBT/vPvB criteria
Endocrine-disrupting properties: The product fails to meet the criteria.

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1

Substance:
Non-applicable

3.2

Mixture:Chemical description: Aqueous solution of organic and inorganic compounds, glycol-ethers, surfactants, enzymes andcolourants.
Components:
None of the substances contained in the mixture are above the limits specified in Annex II of Regulation (EC) No 1907/2006

SECTION 4: FIRST AID MEASURES
4.1

Description of first aid measures:Consult a doctor in case of discomfort showing the SDS for the product.
By inhalation:
In case of symptoms, move the person affected into fresh air.
By skin contact:
In case of contact it is recommended to clean the affected area thoroughly with water and neutral soap. In case of changes to theskin (stinging, redness, rashes, blisters,…), seek medical advice with this Safety Data Sheet- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 4: FIRST AID MEASURES (continued)
By eye contact:
Rinse with water until the product has been eliminated. In case of problems, consult a doctor showing the SDS for the product.
By ingestion/aspiration:
In case of consumption in large quantities, it is recommended to seek medical assistance.
4.2

Most important symptoms and effects, both acute and delayed:
Acute and delayed effects are indicated in sections 2 and 11.

4.3

Indication of any immediate medical attention and special treatment needed:
Non-applicable

SECTION 5: FIREFIGHTING MEASURES
5.1

Extinguishing media:
Suitable extinguishing media:
Product is non-flammable, with a low risk of fire due to the flammability characteristics of the product in normal conditions ofstorage, handling and use. In the case of the existence of sustained combustion as a result of improper handling, storage or use
any type of extinguishing agent can be used (ABC Powder, water,...)
Unsuitable extinguishing media:
Non-applicable

5.2

Special hazards arising from the substance or mixture:
Due to its inflammable nature, the product does not present a fire risk under normal conditions of storage, handling and use.

5.3

Advice for firefighters:
Depending on the magnitude of the fire it may be necessary to use full protective clothing and self-contained breathing apparatus(SCBA). Minimum emergency facilities and equipment should be available (fire blankets, portable first aid kit,...) in accordancewith Directive 89/654/EC.
Additional provisions:
Act in accordance with the Internal Emergency Plan and the Information Sheets on actions to take after an accident or otheremergencies. Eliminate all sources of ignition. In case of fire, cool the storage containers and tanks for products susceptible tocombustion, explosion or BLEVE as a result of high temperatures. Avoid spillage of the products used to extinguish the fire into an
aqueous medium.

SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1

Personal precautions, protective equipment and emergency procedures:
For non-emergency personnel:
Isolate leaks provided that there is no additional risk for the people performing this task.
For emergency responders:
See section 8.

6.2

Environmental precautions:This product is not classified as hazardous to the environment. Keep product away from drains, surface and ground water.

6.3

Methods and material for containment and cleaning up:
It is recommended:

6.4

Absorb the spillage using sand or inert absorbent and move it to a safe place. Do not absorb in sawdust or other combustible
absorbents. For any concern related to disposal consult section 13.
Reference to other sections:
See sections 8 and 13.

SECTION 7: HANDLING AND STORAGE
7.1

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SECTION 7: HANDLING AND STORAGE (continued)
A.- General precautions for safe use
Comply with the current legislation concerning the prevention of industrial risks with regards manually handling weights.
Maintain order, cleanliness and destroy using safe methods (section 6).
B.- Technical recommendations for the prevention of fires and explosions
It is recommended to transfer at a slow speed to avoid the creation of electrostatic charges that could affect flammableproducts. Consult section 10 for conditions and materials that should be avoided.
C.- Technical recommendations on general occupational hygiene
Do not eat or drink during the process, washing hands afterwards with suitable cleaning products.
D.- Technical recommendations to prevent environmental risks
It is not necessary to take special measures to prevent environmental risks. For more information see subsection 6.2
7.2

Conditions for safe storage, including any incompatibilities:
A.- Technical measures for storage
Maximum time:

12 Months

B.- General conditions for storage
Avoid sources of heat, radiation, static electricity and contact with food. For additional information see subsection 10.5
7.3

Specific end use(s):Except for the instructions already specified it is not necessary to provide any special recommendation regarding the uses of thisproduct.

SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1

Control parameters:
Substances whose occupational exposure limits have to be monitored in the workplace (European OEL, not country-specificlegislation):
There are no applicable occupational exposure limits for the substances contained in the product8.2

Exposure controls:
A.- Individual protection measures, such as personal protective equipment
As a preventative measure it is recommended to use basic Personal Protective Equipment, with the corresponding <<CEmarking>> in accordance with Regulation (EU) 2016/425. For more information on Personal Protective Equipment (storage,use, cleaning, maintenance, class of protection,…) consult the information leaflet provided by the manufacturer. For more
information see subsection 7.1. All information contained herein is a recommendation which needs some specification fromthe labour risk prevention services as it is not known whether the company has additional measures at its disposal.
B.- Respiratory protection
The use of protection equipment will be necessary if a mist forms or if the occupational exposure limits are exceeded.
C.- Specific protection for the hands
Pictogram

PPE

Labelling

Chemical protective gloves

CEN Standard

Remarks

EN 420:2004+A1:2010

Replace the gloves at any sign of deterioration.

Mandatory handprotection

As the product is a mixture of several substances, the resistance of the glove material can not be calculated in advance withtotal reliability and has therefore to be checked prior to the application.
D.- Eye and face protection
Pictogram

PPE

Labelling

Panoramic glasses against
splash/projections.

CEN Standard

Remarks

EN 166:2002
EN ISO 4007:2018

Clean daily and disinfect periodically according to
the manufacturer´s instructions. Use if there is arisk of splashing.

Mandatory faceprotection

E.- Body protection- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION (continued)
Pictogram

PPE

Labelling

CEN Standard

Remarks
Replace before any evidence of deterioration. For
periods of prolonged exposure to the product for
professional/industrial users CE III isrecommended, in accordance with the regulations
in EN ISO 6529:2013, EN ISO 6530:2005, EN ISO
13688:2013, EN 464:1994.

Work clothing

F.- Additional emergency measures
It is not necessary to take additional emergency measures.
Environmental exposure controls:
In accordance with the community legislation for the protection of the environment it is recommended to avoid environmental
spillage of both the product and its container. For additional information see subsection 7.1.D

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1

Information on basic physical and chemical properties:
For complete information see the product datasheet.
Appearance:
Physical state at 20 ºC:

LiquidAppearance:

ColorlessColour:Not available

Odour:

Not available

Odour threshold:Non-applicable *Volatility:
Boiling point at atmospheric pressure:

100 ºC

Vapour pressure at 20 ºC:

2350 Pa

Vapour pressure at 50 ºC:

12381,01 Pa (12,38 kPa)

Evaporation rate at 20 ºC:

Non-applicable *Product description:
Density at 20 ºC:

1031,9 kg/m³

Relative density at 20 ºC:

1,032

Dynamic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 20 ºC:

Non-applicable *Kinematic viscosity at 40 ºC:

Non-applicable *Concentration:

Non-applicable *pH:

Non-applicable *Vapour density at 20 ºC:

Non-applicable *Partition coefficient n-octanol/water 20 ºC:

Non-applicable *Solubility in water at 20 ºC:

Non-applicable *Solubility properties:

Completely miscible

Decomposition temperature:

Non-applicable *Melting point/freezing point:

Non-applicable *Flammability:
Flash Point:

Non Flammable (>60 ºC)

Flammability (solid, gas):

Non-applicable *Autoignition temperature:

Non-applicable *Lower flammability limit:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

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SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES (continued)
Upper flammability limit:

Non-applicable *Particle characteristics:
Median equivalent diameter:
9.2

Non-applicable

Other information:
Information with regard to physical hazard classes:
Explosive properties:

Non-applicable *Oxidising properties:

Non-applicable *Corrosive to metals:

Non-applicable *Heat of combustion:

Non-applicable *Aerosols-total percentage (by mass) of flammablecomponents:
Other safety characteristics:

Non-applicable *Surface tension at 20 ºC:

Non-applicable *Refraction index:

Non-applicable **Not relevant due to the nature of the product, not providing information property of its hazards.

SECTION 10: STABILITY AND REACTIVITY
10.1

Reactivity:
No hazardous reactions are expected because the product is stable under recommended storage conditions. See section 7.

10.2

Chemical stability:
Chemically stable under the indicated conditions of storage, handling and use.

10.3

Possibility of hazardous reactions:
Under the specified conditions, hazardous reactions that lead to excessive temperatures or pressure are not expected.

10.4

Conditions to avoid:
Applicable for handling and storage at room temperature:

10.5

10.6

Shock and friction

Contact with air

Increase in temperature

Sunlight

Humidity

Not applicableNot applicableNot applicableNot applicableNot applicable

Acids

Water

Oxidising materials

Combustible materials

OthersAvoid strong acids

Not applicableNot applicableNot applicable

Avoid alkalis or strong bases

Incompatible materials:

Hazardous decomposition products:
See subsection 10.3, 10.4 and 10.5 to find out the specific decomposition products. Depending on the decomposition conditions,complex mixtures of chemical substances can be released: carbon dioxide (CO₂), carbon monoxide and other organic
compounds.

SECTION 11: TOXICOLOGICAL INFORMATION
11.1

Information on hazard classes as defined in Regulation (EC) No 1272/2008:
LD50 oral > 2000 mg/kg (rat)Dangerous health implications:
In case of exposure that is repetitive, prolonged or at concentrations higher than the recommended occupational exposure limits,adverse effects on health may result, depending on the means of exposure:
A- Ingestion (acute effect):- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
B- Inhalation (acute effect):- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 11: TOXICOLOGICAL INFORMATION (continued)- Acute toxicity : Based on available data, the classification criteria are not met- Corrosivity/Irritability: Based on available data, the classification criteria are not met
C- Contact with the skin and the eyes (acute effect):- Contact with the skin: Based on available data, the classification criteria are not met- Contact with the eyes: Based on available data, the classification criteria are not met
D- CMR effects (carcinogenicity, mutagenicity and toxicity to reproduction):- Carcinogenicity: Based on available data, the classification criteria are not met
IARC: Non-applicable- Mutagenicity: Based on available data, the classification criteria are not met- Reproductive toxicity: Based on available data, the classification criteria are not met
E- Sensitizing effects:- Respiratory: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
F- Specific target organ toxicity (STOT) - single exposure:
Based on available data, the classification criteria are not met
G- Specific target organ toxicity (STOT)-repeated exposure:- Specific target organ toxicity (STOT)-repeated exposure: Based on available data, the classification criteria are not met- Skin: Based on available data, the classification criteria are not met
H- Aspiration hazard:
Based on available data, the classification criteria are not met
Other information:
Non-applicableSpecific toxicology information on the substances:
Not available
Acute Toxicity Estimate (ATE mix):
ATE mix

11.2

Ingredient(s) of unknown toxicity

Oral>2000 mg/kg (Calculation method)

Non-applicable

Dermal>2000 mg/kg (Calculation method)

Non-applicable

Inhalation>20 mg/L (4 h) (Calculation method)

Non-applicable

Information on other hazards:
Endocrine disrupting properties
Endocrine-disrupting properties: The product fails to meet the criteria.
Other information
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SECTION 12: ECOLOGICAL INFORMATIONThe experimental information related to the eco-toxicological properties of the product itself is not available
12.1

Toxicity:
Not available

12.2

Persistence and degradability:
Not available

12.3

Bioaccumulative potential:
Not available

12.4

Mobility in soil:
Not available

12.5

Results of PBT and vPvB assessment:
Product fails to meet PBT/vPvB criteria

12.6

Endocrine disrupting properties:
Endocrine-disrupting properties: The product fails to meet the criteria.

12.7

Other adverse effects:
Not described

SECTION 13: DISPOSAL CONSIDERATIONS
13.1

Waste treatment methods:
Code
16 05 09

Description
discarded chemicals other than those mentioned in 16 05 06, 16 05 07 or 16 05 08

Waste class (Regulation (EU) No
1357/2014)
Non dangerous

Type of waste (Regulation (EU) No 1357/2014):
Non-applicable
Waste management (disposal and evaluation):
Consult the authorized waste service manager on the assessment and disposal operations in accordance with Annex 1 andAnnex 2 (Directive 2008/98/EC). As under 15 01 (2014/955/EC) of the code and in case the container has been in direct contact
with the product, it will be processed the same way as the actual product. Otherwise, it will be processed as non-dangerous
residue. Waste should not be disposed of to drains. See paragraph 6.2.
Regulations related to waste management:
In accordance with Annex II of Regulation (EC) No 1907/2006 (REACH) the community or state provisions related to waste
management are stated
Community legislation: Directive 2008/98/EC, 2014/955/EU, Regulation (EU) No 1357/2014

SECTION 14: TRANSPORT INFORMATIONOther information:
The product is not covered by international regulations on the transport of dangerous goods (IMDG, IATA, ADR/RID).
Transport of dangerous goods by land:With regard to ADR 2021 and RID 2021:- CONTINUED ON NEXT PAGE Printing: 24/06/2022

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SECTION 14: TRANSPORT INFORMATION (continued)
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Environmental hazards:
No14.6 Special precautions for user
Special regulations:Non-applicable
Tunnel restriction code:
Non-applicable
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by sea:
With regard to IMDG 39-18:
14.1
14.2
14.3

UN number or ID number:
Non-applicable
UN proper shipping name:Non-applicable
Transport hazard class(es):Non-applicableLabels:Non-applicable
14.4 Packing group:
Non-applicable
14.5 Marine pollutant:No
14.6 Special precautions for user
Special regulations:Non-applicable
EmS Codes:
Physico-Chemical properties:
see section 9
Limited quantities:
Non-applicable
Segregation group:
Non-applicable
14.7 Maritime transport in bulk
Non-applicableaccording to IMO instruments:
Transport of dangerous goods by air:With regard to IATA/ICAO 2022:
14.1
14.2
14.3
14.4
14.5
14.6
14.7

UN number or ID number:UN proper shipping name:
Transport hazard class(es):Labels:Packing group:
Environmental hazards:
Special precautions for user
Physico-Chemical properties:

Non-applicableNon-applicableNon-applicableNon-applicableNon-applicableNo
see section 9

Maritime transport in bulk
Non-applicableaccording to IMO instruments:

SECTION 15: REGULATORY INFORMATION
15.1

Safety, health and environmental regulations/legislation specific for the substance or mixture:
Candidate substances for authorisation under the Regulation (EC) No 1907/2006 (REACH): Non-applicable
Substances included in Annex XIV of REACH ("Authorisation List") and sunset date: Non-applicable
Regulation (EC) No 1005/2009, about substances that deplete the ozone layer: Non-applicable
Article 95, REGULATION (EU) No 528/2012: Non-applicable
REGULATION (EU) No 649/2012, in relation to the import and export of hazardous chemical products: Non-applicable
Limitations to commercialisation and the use of certain dangerous substances and mixtures (Annex XVII REACH, etc ….):
Non-applicableSpecific provisions in terms of protecting people or the environment:- CONTINUED ON NEXT PAGE -Printing: 24/06/2022

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SECTION 15: REGULATORY INFORMATION (continued)
It is recommended to use the information included in this safety data sheet as a basis for conducting workplace-specific risk
assessments in order to establish the necessary risk prevention measures for the handling, use, storage and disposal of thisproduct.
Other legislation:
The product could be affected by sectorial legislation
15.2

Chemical safety assessment:
The supplier has not carried out evaluation of chemical safety.

SECTION 16: OTHER INFORMATION
Legislation related to safety data sheets:
The SDS shall be supplied in an official language of the country where the product is placed on the market. This safety data sheet
has been designed in accordance with ANNEX II-Guide to the compilation of safety data sheets of Regulation (EC) No 1907/2006(COMMISSION REGULATION (EU) 2020/878).
Modifications related to the previous Safety Data Sheet which concerns the ways of managing risks.:
Non-applicable
Texts of the legislative phrases mentioned in section 3:
The phrases indicated do not refer to the product itself; they are present merely for informative purposes and refer to theindividual components which appear in section 3
CLP Regulation (EC) No 1272/2008:
Non-applicable
Classification procedure:
Non-applicable
Advice related to training:
Training is recommended in order to prevent industrial risks for staff using this product and to facilitate their comprehension andinterpretation of this safety data sheet, as well as the label on the product.
Principal bibliographical sources:
http://echa.europa.eu
http://eur-lex.europa.eu
Abbreviations and acronyms:
ADR: European agreement concerning the international carriage of dangerous goods by road
IMDG: International maritime dangerous goods code
IATA: International Air Transport Association
ICAO: International Civil Aviation Organisation
COD: Chemical Oxygen Demand
BOD5: 5day biochemical oxygen demand
BCF: Bioconcentration factor
LD50: Lethal Dose 50
LC50: Lethal Concentration 50
EC50: Effective concentration 50
LogPOW: Octanolwater partition coefficient
Koc: Partition coefficient of organic carbon
UFI: unique formula identifier
IARC: International Agency for Research on Cancer

Product safety information sheet prepared in accordance with Article 32 of Regulation (EC) 1907/2006 (REACH); this document does not constitute a Safety Data Sheet under Article 31 ofRegulation (EC) No. 1907/2006, as a Safety Data Sheet is not mandatory for this productThe information contained in this safety data sheet is based on sources, technical knowledge and current legislation at European and state level, without being able to guarantee its accuracy. This
information cannot be considered a guarantee of the properties of the product, it is simply a description of the security requirements. The occupational methodology and conditions for users of thisproduct are not within our awareness or control, and it is ultimately the responsibility of the user to take the necessary measures to obtain the legal requirements concerning the manipulation,
storage, use and disposal of chemical products. The information on this safety data sheet only refers to this product, which should not be used for needs other than those specified.

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