ROOM A
16:00

Opening Lectures – Invitation to Polyphenol Research –16:00-16:30
Chair: Junji Terao, Japan
OL1
Polyphenols as antioxidants: Chemistry versus physiology
Cesar G. Fraga, University of California, Davis, USA
16:30-17:00
Chair: Hiroshi Chuman, JapanOL2
The absorption and metabolism of polyphenols
Jennifer L. Donovan, Medical University of South Carolina,
USA*Opening Lectures are sponsored by The University of Tokushima Center of Excellence Program.

17:10

Opening Remarks

17:30

Keynote Lectures

17:30-18:00
Chair: Hajime Ohigashi, Japan
KL1
Dietary flavanols and vascular responsesHelmut Sies, Heinrich-Heine University of Dusseldorf, Germany
18:00-18:30
Chair: Augustin Scalbert, FranceKL2
Recent development of polyphenol research by collaboration
between industrial and academic sectors for application in humanhealthToshihiko Osawa, Nagoya University, Japan

3rd International Conference on Polyphenols and Health   11

SCIENTIFIC PROGRAM

Sunday November 25th 2007

SCIENTIFIC PROGRAM

Monday November 26th 2007
ROOM A
08:30

Symposium 1: Food Chemistry
Chairs: Andrew L. Waterhouse, USA
Michikatsu Sato, Japan

08:30 – 08:55
S01-1
Agricultures influence on food composition: a comparison offlavonoids in organic and conventionally grown tomatoes
Alyson E. Mitchell, University of California, Davis, USA
08:55 – 09:20
S01-2
The polymerization degree and stereochemistry of procyanidins
affect the physiological functions of the cells
Toshihiko Shoji, Asahi Breweries, Ltd., Japan
09:20 – 09:45
S01-3
Effect of food processing on polyphenol bioavailability
Francisco A. Tomas-Barberan, CEBAS (CSIC), Spain
09:45 – 10:10
S01-4
Understanding and modulating flavonoid biosynthesis in plants
Christian Dubos, INRA-AgroParisTech, France
10:10 – 10:25
S01-5
Antioxidation reaction mechanism of polyphenols, caffeic acidand related compounds
Toshiya Masuda, University of Tokushima, Japan
Tea and Coffee Break
10:45

Symposium 3: Bioavailability & Metabolism
Chairs: Herman Adlercreutz, Finland
Alan Crozier, UK
10:45 – 11:10
S03-1
Absorption and metabolism of flavonoids from standard portions ofvarious fruits - impact of processing, dose and subject variation
Paul A. Kroon, Institute of Food Research, Norwich, UK
11:10 – 11:35
S03-2
Bioavailability of dietary lignans in humans
José L. Peñalvo, University San Pablo CEU, Spain
11:35 – 12:00
S03-3Immunochemical characterization of dietary flavonoid metabolites
in aorta: Implication in the anti-atherosclerosis effectYoshichika Kawai, The University of Tokushima, Japan
12:00 – 12:25
S03-4
Human and animal studies on the bioavailability and metabolism ofdietary phenolics
Alan Crozier, University of Glasgow, UK
12:25 – 12:40
S03-5
Conversion of procyanidins by human intestinal microbiota
Annett Braune, German Institute of Human Nutrition PotsdamRehbruecke, Germany
12

3rd International Conference on Polyphenols and Health08:30Symposium 2: Allergy & Inflammation
Chairs: Hisanori Suzuki, Italy
Mari Maeda-Yamamoto, Japan
08:30 – 08:55
S02-1
Anti-allergic action of O-methylated catechin in green tea
Mari Maeda-Yamamoto, National Institute of Vegetable and Tea
Science, Japan
08:55 – 09:20
S02-2
Dietary apple procyanidins inhibit the development of oral
sensitization and food allergies
Hiroshi Akiyama, National Institute of Health Science, Japan
09:20 – 09:45
S02-3
Targeting STAT1 by epigallocatechin gallate, myricetin anddelphinidin provides efficient protection in ischemia/reperfusioninduced heart injury
Hisanori Suzuki, University of Verona, Italy
09:45 – 10:10
S02-4
Vascular protection by grape-derived polyphenols
Valérie B. Schini-Kerth, Universite Louis Pasteur de Strasbourg,
France10:10 – 10:25
S02-5
Modulation of the signaling NF-κB activation pathway bypolyphenols in human intestinal Caco-2 cells
Beatrice Romier-Crouzet, Universite catholique de Louvain,
Belgium
Tea and Coffee Break
10:45

Symposium 4: Cognitive Function
Chairs: Jim A. Joseph, USA
Hiramitsu Suzuki, Japan
10:45 – 11:10
S04-1
Green tea consumption and cognitive function: a cross-sectional study
Shinichi Kuriyama, Tohoku University, Japan
11:10 – 11:35
S04-2Flavonoids as neurotrophic factors
Pamela A. Maher, The Salk Institute of Biological Studies, USA
11:35 – 12:00
S04-3
Molecular mechanisms underlying the cognitive effects ofpolyphenols
Jeremy P. E. Spencer, University of Reading, UK
12:00 – 12:25
S04-4
Proteomic profiling for evaluating the neuroprotective mechanismof green tea polyphenols: prospective for neurodegenerative
disease therapy
Orly Weinreb, Technion-Israel Institute of Technology, Israel
12:25 – 12:40
S04-5
Curcumin attenuates diabetic encephalopathy in rats: behavioral,
biochemical and anti-inflammatory evidences
Anurag Kuhad, Panjab University, India
3rd International Conference on Polyphenols and Health   13

SCIENTIFIC PROGRAM

ROOM B1

SCIENTIFIC PROGRAM

12:40-13:40 Lunch
ROOM A
13:40

Sponsored Symposium 1: Tea and Health
Chairs: Balz Frei, USA
Francesco Visioli, France

13:40 – 14:05
SS1-1
Polyphenols in cardiovascular disease: effects on endothelial
function
Joseph A. Vita, Boston University School of Medicine, USA
14:05 – 14:30
SS1-2
Recent epidemiologic studies on green tea consumption andcancer risk in Japan
Manami Inoue, National Cancer Center, Japan
14:30 – 14:55
SS1-3
Chemoprevention of human prostate cancer by oral administrationof green tea catechins
Saverio Bettuzzi, University of Parma, Italy
Tea and Coffee Break
15:20 – 15:45
SS1-4
Effects of white tea, caffeine and EGCG on 2-amino-1-methyl-6phenyl-imidazo[4,5-b]pyridine (PhIP)-induced tumorigenesis andβ-catenin expression
Roderick H. Dashwood, Linus Pauling Institute, USA
15:45 – 16:10
SS1-5
Does tea reduce body weight and alleviate diabetes?
Chung S. Yang, Rutgers, The State University of New Jersey,USA
16:10 – 16:35
SS1-6
Paradoxical effects of green tea and antioxidant vitamins indiabetes: improved oxidant stress but worsened carbonyl stressVincent M. Monnier, Case Western Reserve University, USA
16:35 – 16:55
Panel Discussion* This symposium is sponsored by Mitsui Norin Co.,Ltd., Kao Co., Linus Pauling Institute,
DSM and Te Infre.

14

3rd International Conference on Polyphenols and Health13:40Symposium 5: Pharmaceuticals
Chairs: Tsutomu Hatano, Japan
Takashi Yoshida, Japan

13:40 – 14:05
S05-1
In vitro immunomodulatory effects of polyphenols on macrophages
Herbert Kolodziej, Freie Universitaet Berlin, Germany14:05 – 14:30
S05-2
Antioxidant, antimalarial and antimicrobial activities of polyphenols
from Punica granatum L.
Daneel Ferreira, The University of Mississippi, USA
14:30 – 14:55
S05-3
New aspects of green tea catechins in relation to DNA and RNA
molecules
Takashi Kuzuhara, Tokushima Bunri University, Japan
14:55 – 15:20
S05-4
Functional evaluation of polyphenols as alternative medicine
Hiroshi Sakagami, Meikai University, Japan
15:20 – 15:35
S05-5
Nasal administration of quercetin liposomes improves antidepression like effect and enhances memory
Wathita Phachonpai, Khon Kaen University, Thailand
Tea and Coffee Break

ROOM B2, D and E
17:00 – 18:00

Poster Session

3rd International Conference on Polyphenols and Health   15

SCIENTIFIC PROGRAM

ROOM B1

SCIENTIFIC PROGRAM

Tuesday, November 27th, 2007
ROOM A
08:30

Symposium 6: Metabolic Syndrome
Chairs: Gary Williamson, UK
Yoshinobu Kiso, Japan
08:30 – 08:55
S06-1
Tea and cinnamon polyphenols improve the metabolic syndrome
Richard A. Anderson, Beltsville Human Nutrition ResearchCenter, USA
08:55 – 09:20
S06-2
The effect of dietary flavonoids on cardiovascular risk
Kevin D. Croft, University of Western Australia, Australia
09:20 – 09:45
S06-3
Prevention of metabolic syndrome by oolong tea polymerized
polyphenols and sesamin
Yoshinobu Kiso, SUNTORY Ltd., Japan
09:45 – 10:10
S06-4
Regulation of adipocyte function by polyphenols-possibility ofpreventing the metabolic syndromeTakanori Tsuda, Chubu University, Japan
10:10 – 10:25
S06-5
Daily consumption of an aqueous green tea extract does not affectvascular reactivity or risk factors for coronary heart disease inhealthy men
Jan Frank, Christian Albrechts University, Germany
Tea and Coffee Break
10:45

Symposium 9: Oxidative Stress & Cell Signaling
Chairs: Barry Halliwell, Singapore
Tsutomu Nakayama, Japan
10:45 – 11:10
S09-1
Beneficial effects of phenolic acids and their role in antiobesity
Gow-Chin Yen, National Chung Hsing University, Taiwan
11:10 – 11:35
S09-2
Polyphenols and genomic instability: From molecules to man
Susan J. Duthie, Rowett Research Institute, UK
11:35 – 12:00
S09-3
Disruption of defense mechanisms against oxidative damage innucleic acids and the affect of polyphenols
Yusaku Nakabeppu, Kyushu University, Japan
12:00 – 12:25
S09-4
Modulation of transcription factor NF-κB by flavan-3 ols andprocyanidins
Patricia I. Oteiza, University of California, Davis, USA
12:25 – 12:40
S09-5
Protective effects of quercetin and its human conjugatedmetabolites on cardiovascular disease
Federica Lodi, Institute of Food Research, Norwich, UK
16

3rd International Conference on Polyphenols and Health08:30Symposium 7: (Poly)methoxyflavonoids
Chairs: Chi-Tang Ho, USA
Kayoko Shimoi, Japan
08:30 – 08:55
S07-1
Chemistry and biology of polymethoxyflavones and hydroxylated
polymethoxyflavones
Chi-Tang Ho, Rutgers University, USA
08:55 – 09:20
S07-2
Nobiletin treatment and the prevention of atherosclerosis in amouse model of the disease
Stewart C. Whitman, University of Ottawa, Canada
09:20 – 09:45
S07-3
Versatile effects of citrus polymethoxyflavonoids on inflammatory
cells
Akira Murakami, Kyoto University, Japan
09:45 – 10:10
S07-4
Antiproliferative and antimetastatic potential of methoxyflavonoids
derived from Artemisia plants
Hye-Kyung Na, Seoul National University, Korea
10:10 – 10:25
S07-5
Flavonoid metabolites mono-O-methylated at the B ring are
inhibitors of endothelial NADPH oxidase activity
Tankred Schewe, Heinrich Heine University, Germany
Tea and Coffee Break
10:45

Symposium 8: Nutrigenomics
Chairs: Roger Corder, UK
Ichiro Matsumoto, Japan
10:45 – 11:10
S08-1
Impact of sesame lignans affecting gene expression profile in ratliver
Takashi Ide, National Food Research Institute, Japan
11:10 – 11:35
S08-2
Procyanidin regulation of the vascular endothelium - From genes tofunction
Roger Corder, William Harvey Research Institute, UK
11:35 – 12:00
S08-3
Dietary polyphenols and atherosclerosis - Analysing their mode ofaction in a mice model by a transcriptomic approach
Dragan Milenkovic, INRA-UMR, France
12:00 – 12:25
S08-4
Ilex paraguariensis herbal extract-induced changes in the visceraladipose tissue gene expression profile of rats fed high-fat diet
Taesun Park, Yonsei University, Korea
12:25 – 12:40
S08-5
The effect of quercetin on ER stress at intestinal epithelia
Yayoi Natsume, The University of Tokyo, Japan
3rd International Conference on Polyphenols and Health   17

SCIENTIFIC PROGRAM

ROOM B1

SCIENTIFIC PROGRAM

12:40-13:40 Lunch

ROOM A
13:40

Symposium 10: Epidemiology & Intervention Study
Chairs: Adrian Franke, USA
Peter C. Hollman, The Netherlands
13:40 – 14:05
S10-1
Polyphenols and health: Evidence from epidemiology andintervention studies
Peter C. Hollman, RIKILT, The Netherlands
14:05- 14:30
S10-2
Prospective studies of green tea and cancer and cardiovasculardisease in Japan
Yoshitaka Tsubono, Tohoku University, Japan
14:30 -14:55
S10-3
Soy isoflavones: Bioavailability and breast cancer preventive
effects
Adrian A. Franke, Cancer Research Center of Hawaii, USA
14:55 – 15:20
S10-4
Dietary and endogenous redox network: The antioxidant "weight"of flavonoids rich foods
Mauro Serafini, INRAN, Italy
15:20 – 15:35
S10-5
Intake of flavonoids and risk of cancer in Finnish men: The Kuopio
Ischaemic Heart Disease Risk Factor Study
Jaakko Mursu, University of Kuopio, Finland
Tea and Coffee Break18

3rd International Conference on Polyphenols and Health13:40Sponsored Symposium 2: Anthocyanin
Chairs: Andrew L. Waterhouse, USA
De-Xing Hou, Japan
13:40 – 14:05
SS2-1
Bilberry anthocyanins and biological activities
De-Xing Hou, Kagoshima University, Japan
14:05 – 14:30
SS2-2
Biological behaviors of bilberry anthocyanins
Takashi Ichiyanagi, Niigata University of Pharmacy and AppliedLife Sciences, Japan
14:30 – 14:55
SS2-3
Stress signaling in and the modulation of age-related behavioral
decline via dietary fruit and walnut supplementation
Jim A Joseph, USDA HNRCA at Tufts University, USA
14:55 – 15:20
SS2-4
New perspectives and medical application of the Vaccinium
myrtillus extract
Ezio Bombardelli, Indena SpA, Italy* This symposium is sponsored by Natural Way Co., Ltd.

Tea and Coffee BreakRoom B2, D and E
16:00 – 17:00

Poster Session

19:00

Banquet (Grand Prince Hotel Kyoto)

3rd International Conference on Polyphenols and Health   19

SCIENTIFIC PROGRAM

ROOM B1

SCIENTIFIC PROGRAM

Wednesday, November 28th, 2007
MAIN HALL
09:30

Joint Keynote Lectures

09:30 – 10:10
Chair: Toshihiko Osawa, JapanJKL1Polyphenols and inflammatory effects
Andrew L. Waterhouse, University of California, Davis, USA
10:10 – 10:50
Chair: Shaw Watanabe, JapanJKL2Genomics for food functionality and palatability
Keiko Abe, The University of Tokyo, Japan
10:50 – 11:30
Chair: Hajime Ohigashi, Japan
JKL3
Searching for molecular targets of chemopreventive andchemoprotective phytochemicals: Signal transduction network asa road map
Young-Joon Surh, Seoul National University, Korea
11:40

Invited Lecture I (Sponsored by ICoFF)
Chair:Toshikazu Yoshikawa, Japan
11:40 – 12:40
IL1
Molecular mechanism of α-tocopherol action
Angelo Azzi, The Jean Mayer USDA Human Nutrition Center, USA* Invited Lecture 1 is co-organized with the 19th Meeting of Japanese
Vitamin E Research Association.

Lunchboxes will be served.
12:45

Joint Symposium 1: Cancer Prevention I
Chairs: Zigang Dong, USA
Hyong Joo Lee, Korea
12:45 – 13:10
SJ1-1
Targeting inflammation for prevention and treatment of cancer:
Food for thoughtBharat B. Aggarwal, The University of Texas, USA
13:10 – 13:35
SJ1-2
Molecular action of cancer-preventive effect of cocoa polyphenols
Hyong Joo Lee, Seoul National University, Korea
13:35 – 14:00
SJ1-3
Green tea polyphenol EGCG signaling through 67kDa laminin
receptor
Hirofumi Tachibana, Kyushu University, Japan
14:00 – 14:25
SJ1-4
Molecular targets of polyphenols on cancer prevention
Zigang Dong, University of Minnesota, USA
14:25 – 14:40
SJ1-5
Up-regulation of GADD153 gene with combination of green tea
polyphenol and cancer preventive agent is a new mechanism ofcancer prevention
Masami Suganuma, Saitama Cancer Center, Japan20

3rd International Conference on Polyphenols and Health

SCIENTIFIC PROGRAM
ROOM A
11:40

Invited Lecture 2 (Sponsored by ICoFF)
Chair: Junji Terao, Japan
11:40 – 12:40
IL2
Phytonutrients as antioxidants: Where are we?
Cesar G. Fraga, University of California, Davis, USA
Lunchboxes will be served.
12:45

Joint Symposium 2: Phytoestrogens
Chairs: Johanna W. Lampe, USA
Mariko Uehara, Japan
12:45 – 13:10
SJ2-1
Phytoestrogens: Interindividual variation in their metabolism andimpact on biologic response
Johanna W.Lampe, Fred Hutchinson Cancer Research Center,USA
13:10 – 13:35
SJ2-2
Dietary soy and risk of breast cancer
Chisato Nagata, Gifu University, Japan
13:35 – 14:00
SJ2-3
Effects of soybean isoflavones on bone health and its safety inpostmenopausal Japanese women
Yoshiko Ishimi, National Institute of Health and Nutrition, Japan
14:00 -14:25
SJ2-4
Lignans and human health
Herman Adlercreutz, University of Helsinki, Finland
14:25 – 14:40
SJ2-5
Microbial and dietary factors associated with the equol and8-prenylnaringenin producer phenotypes
Selin Bolca, Ghent University, Belgium

3rd International Conference on Polyphenols and Health   21

SCIENTIFIC PROGRAM

MAIN HALL
15:00

Plenary Lectures

15:00 -15:30
Chair: Hitoshi Ashida, Japan
PL1
Are polyphenols good, bad, or indifferent?
Barry Halliwell, National University of Singapore, Singapore
15:30-16:00
PL2

Chair: Kazuki Kanazawa, Japan
Factors affecting the bioavailability of polyphenols
Gary Williamson, University of Leeds, UK

16:00-16:30
PL3

Chair: Mamoru Isemura, Japan
Tea and cancer prevention: Mechanisms and human relevance
Chung S. Yang, Rutgers, the State University of New Jersey,USA

16:45-17:15
PL4

Chair: Teruo Miyazawa, Japan
Evidence for a positive influence of flavanol on vascular healthCarl Keen, University of California, Davis, USA

17:15-17:45
PL5

Chair: Cesar Fraga, USA
Evaluation of polyphenol safety focused on chromosomal damage
and interaction with drugs
Keizo Umegaki, National Institute of Health and Nutrition, Japan

17:45-18:15
PL6

Chair: Makoto Shimizu, Japan
Unraveling the complex links between dietary polyphenols andhealth: Think global rather than targeted.
Augustin Scalbert, INRA, France

18:15

Closing Remarks

22

3rd International Conference on Polyphenols and HealthPoster Session

Roomnumbers

Posternumbers

Presentation
time

Food Chemistry

EP001~073

Nov. 26 17:00-18:00

Allergy & Inflammation

EP074~079

Nov. 26 17:00-18:00

Bioavailability &Metabolism

DP080~141

Nov. 26 17:00-18:00

Cognitive Function

DP142~152

Nov. 26 17:00-18:00

Pharmaceuticals

B2

P153~167

Nov. 26 17:00-18:00

Metabolic Syndrome

E

P169~197

Nov. 27 16:00-17:00(Poly)methoxyflavonoids

E

P198~204

Nov. 27 16:00-17:00

Nutrigenomics

B2

P205~217

Nov. 27 16:00-17:00

DP218~262

Nov. 27 16:00-17:00DP263~273

Nov. 27 16:00-17:00*Cancer Prevention

EP274~303

Nov. 27 16:00-17:00*Phytoestrogens

EP304~310

Nov. 27 16:00-17:00

Oxidative Stress & Cell
Signaling
Epidemiology &Intervention Study

Abstract
page

Posters numbered P008, P168, P259, P260, P271, and P272 were withdrawn.
*Cancer Prevention and Phytoestrogens are held as joint sessions with ICoFF2007 atRoom E. Please see Supplemental Abstracts in the same categories of ICoFF2007 in Page
XX.

3rd International Conference on Polyphenols and Health   23

POSTER SESSION

All participants are invited to come and view the posters which will be displayed in Room
B2, D and E from Monday November 26th through Tuesday November 27th.
Poster presentations are scheduled for Monday Nov. 26th from 17:00-18:00 and Tuesday
Nov. 27th from 16:00-17:00.
Authors are requested to stand by their posters during the presentation time indicatedbelow.