ඛ➃໬Ꮫ⏕࿨ᕤᏛ◊✲ D&<%(5 ࢭࣥࢱ࣮άືሗ࿌                    aCYBER ࢭࣥࢱ࣮㛗 ⓑ▼ ᾈᖹ  ᡤဨ ᒣ⏣ ᗣᯞ㸪Ώ㑓 ⩏அ㸪ᑠᕝ ᬛᘯ㸬ᖹᡂ  ᖺᗘάືሗ࿌ࣄࢺ⣽⬊ᰴࡢ฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲㸦ⓑ▼㸪ᒣ⏣㸧<┠ⓗ> ⣽⬊᥋╔ࢆไᚚࡍࡿ㧗ศᏊ⏕యᮦᩱ࠶ࡿ࠸ࡣᇶᯈ࡜ࡑࢀࡽ࡜ࣟ࣎ࢸ࢕ࢡࢫࢆ⼥ྜࡋࡓ㑇ఏᏊ㸪ࢱࣥࣃࢡ㉁ࡢ⥙⨶ⓗゎᯒ࠶ࡿ࠸ࡣ⣽⬊᧯స㸦ᅇ཰࣭⼥ྜ㸧⏝⿦⨨ཬࡧࢩࢫࢸ࣒ࡢ㛤Ⓨ㸦ⓑ▼㸪ᒣ⏣㸧㸦⌧≧࡜⤖ᯝ㸧⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖ࡢ◊✲࡟࠾࠸࡚㸪⣽⬊ࢆ⏝࠸ࡓࣁ࢖ࢫ࣮ࣝࣉࢵࢺ࡞ᶵ⬟ゎᯒࡢࡓࡵࡢᇶᮦ㛤Ⓨ㸪ୗ㝈⮫⏺ඹ⁐ᗘᆺ㸪ୖ㝈⮫⏺ඹ⁐ᗘᆺᗘᛂ⟅ᛶ࣏࣐࣮ࣜࡢ㛤Ⓨ㸪㔠ࢫ࣏ࢵࢺ࡬ࡢ㑅ᢥⓗ࡞⣽⬊ࡢ᥋╔ࡀྍ⬟࡞⣽⬊࢔ࣞ࢖ࡢㄪ〇㸪⣽⬊᥋╔㡿ᇦ㸪㠀᥋╔㡿ᇦࡢᵓ⠏㸪⣽⬊᥋╔ᚋࡢ⣽⬊ᶵ⬟ࡢ᳨ウ㸪ࣄࢺேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ࢆᑟධ
ࡍࡿ⣽⬊⼥ྜ⏝ᇶᯈ࡜ࣃࣝࢫ࣮ࣞࢨ࣮ග↷ᑕࡢే⏝࡟ࡼࡿ⣽⬊⼥ྜ㸪CW ࣮ࣞࢨ࣮ගࣆࣥࢭࢵࢺ㸪CW ࣮ࣞࢨ࣮ගຍ➼࡟せ⣲ᢏ⾡ࡢ᮲௳タᐃࢆ㐍ࡵࡓ㸬ࡉࡽ࡟㸪⣽⬊ᇵ㣴᫬ࡢ⣽⬊ቑṪ➼࡬ࡢᙳ㡪ࢆ୚࠼ࡿ㓟⣲ࢆ⣽⬊᥋╔㠃࠿ࡽ⣽⬊ᐩ໬⭷ࢆᇶᮦ࡜ࡋࡓᗘᛂ⟅ᛶ࣏࣐࣮ࣜࢢࣛࣇࢺ໬ᇶᯈࢆㄪ〇ࡋ࡚⣽⬊ቑṪ࡟㓟⣲౪⤥ࡀ᭷ຠ࡛࠶ࡿࡇ࡜ぢฟࡋࡓ㸬࣮ࣞࢨ࣮࡟ࡼࡾ୙⏝࡞⣽⬊ࢆ㝖ࡃ࠶ࡿ࠸ࡣ᭷⏝⣽⬊ࡢࡳࢆ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰ࡍࡿࢩࢫࢸ࣒ཬࡧ⿦⨨ࢆ㛤Ⓨࡋ࡚࠸ࡿ㸬᪂ࡓ࡟ㄏ㟁㟁ẼὋືἲࢆ⏝࠸ࡓ⣽⬊㞟✚࡜⣽⬊㸫⣽⬊㛫᥋╔࡟ㄏᘬࡍࡿ᪂ἲࢆຍ࠼࡚㸪HAC ࣋ࢡࢱ࣮ࡸ⾑⌫⣔ཷᐜ⣽⬊(U937)ࡢ㞟✚ࢆ☜ㄆࡋ㸪㞟✚᮲௳஺ὶ㟁ᅽ࣭࿘Ἴᩘࡉࡽ࡟ࡣ⾲㠃࡬ࡢ⼥ྜ⣲ᮦ➼ࡢᅛᐃ໬ࢆ᳨ウࡋ࡚㸪ࣃࣝࢫ࣮ࣞࢨ࣮ග↷ᑕ࡜ࡢే⏝࡟ࡼࡗ࡚⣽⬊⼥ྜࡢ㣕㌍ⓗ࡞ྥୖࢆ㐍ࡵ࡚࠸ࡿ㸬㸦◊✲ィ⏬㸧⣽⬊࢔ࣞ࢖ࢆ⏝࠸࡚᭷⏝⣽⬊࡜デ᩿ࡉࢀࡓ࢔ࣞ࢖ࢫ࣏ࢵࢺୖ࡟࣮ࣞࢨ࣮ග࡛ຍࡋ࡚⣽⬊ࢆ㑅ᢥⓗ࠿ࡘ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰࡟ࢩࢫࢸ࣒㐍໬ࡉࡏ㸪ࡉࡽ࡟ຠ⋡ࡼࡃ⣽⬊᳨ฟ࣭ศูࡀฟ᮶ࡿ᮲௳ࢆᅛᐃ໬⣲ᮦࡢ໬Ꮫᵓ㐀ࡸᅛᐃ໬≧ែࢆ᳨ウࡋ࡚࠸ࡿ㸬⾲㠃࡟ฎ⌮ࡍࡿᶵ⬟ᛶ⣲ᮦࢆᗮ౯࡛ࡇࢀࡲ࡛ࡢྠࡌ࠶ࡿ࠸ࡣࡑࢀ௨ୖࡢᶵ⬟ࢆ㐩ᡂࡍࡿࡓࡵ࡟⣲ᮦࡢࢥ࣮ࢸ࢕ࣥࢢࡢࡳ࡟ࡼࡿᅛᐃ໬࡜໬Ꮫᵓ㐀ࡢ᭱㐺໬ࢆ㐍ࡵ࡚࠸ࡿ㸬Ỉᬗ᣺ືᏊ࣐࢖ࢡࣟࣂࣛࣥࢫἲ࡟ࡼࡗ࡚ཷᐜ⣽⬊ࡢ୍ᐃࡢὶ㏻⣔ࡢ࡞࠿࡛ࡢᅛᐃ໬ࡢ᳨ウࢆ㐍ࡵ࡚࠸ࡿ㸬ࡲࡓ᧯సࡢ⮬ື໬ࢆど㔝࡟ධࢀࡓࣂ࢖࢜ࢳࣕࣥࣂ࣮ࢆྵࡴࣟ࣎ࢵࢺ㥑ື᮲௳࡜᭱㐺໬ࢆ࡯ࡰ⤊஢ࡋࡓ㸬ᅜෆእࡢ࣮ࣘࢨ࣮࡜ࡢ᥋Ⅼࢆࡶࡘࢥࣥࢧࣝࢱࣥࢺᴗົࡢ㛵㐃఍♫ࡢ⤂௓ࢆཷࡅ㸪࣮ࣘࢨ࣮㛤ᣅ࡜ྠ᫬࡟⿦⨨ᵓᡂ࣭ࢩࢫࢸ࣒ࡢ⣽⬊デ᩿࣭ᅇ཰࣭⼥ྜࢆ࣮ࣘࢨ࣮࢝ࢫࢱ࣐࢖ࢬ໬ࡋࡓ⿦⨨ࡢ㛤Ⓨࢆ㐍ࡵ࡚㸪ࡉࡽ࡞ࡿᐇ⏝໬᳨ウࢆ㐍ࡵࡿ㸬<┠ⓗ>᪥ᮏ㓇ᡂศࡢ୰ࡢ᭷ຠᡂศࡢᵓ㐀Ỵᐃࢆ⾜࠸㸪ࢧࣉ࣓ࣜࣥࢺ㸪་⸆࡬ࡢᛂ⏝ࢆ᳨ウࡍࡿ㸬㸦ᒣ⏣㸧－ 37 －㸦⌧≧࡜⤖ᯝ㸧᪥ᮏ㓇ᡂศࡢศ⏬࡜࣓ࢱ࣮࣒࣎ࣟゎᯒࢆ⾜࠸㸪ࣄࢺࡢ╧╀ࡸᢠ୙Ᏻຠᯝ࡟㔜せ࡞ാࡁࢆࡋ࡚࠸ࡿ GABAA ཷᐜయάᛶཬࡧ NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ㸪࢝ࣉࢧ࢖ࢩࣥཷᐜయ࡟ᑐࡍࡿ᪥ᮏ㓇ᡂศࡢຠᯝࢆ᳨ウࡍࡿ㸬ཷᐜయࡢ㜼ᐖάᛶࡸసືάᛶࡀᚓࡽࢀࡓ≀㉁࡟ࡘ࠸࡚ࡑࡢຠᯝࢆヲ⣽࡟᳨ウࡋࡓ㸬GABAA ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 16 ᡂศぢฟࡋࡓ㸬ࡇࢀࡲ࡛㸪㙠㟼࣭ദ╀⸆㸪ᢠ②ᨥ⸆ࡸᢠ୙Ᏻ⸆ࡣ໬Ꮫ≀㉁࡛࠶ࡗࡓࡀ㸪௒ᅇぢࡘࡅࡓ≀㉁ࡣྂ᮶ࣄࢺࡀᦤྲྀࡋ࡚ࡁࡓ᪥ᮏ㓇࡟ྵࡲࢀࡿኳ↛ᡂศ࡛࠶ࡾ㸪⏕యෆ࡟ࡶᬑ㐢ⓗ࡟Ꮡᅾࡍࡿࡶࡢࡀከ࠸ࡓࡵ㸪⸆࡜ࡋ࡚ࡶᏳ඲ᛶࡀ㧗ࡃ㸪ࡲࡓᶵ⬟ᛶ㣗ရ࡬ࡢᛂ⏝ࡶྍ⬟࡛࠶ࡿ㸬ྠᵝࡢάᛶࡢ࠶ࡿ≀㉁ࡣࡇࢀࡲ
࡛㸪ぢࡘ࠿ࡗ࡚࠾ࡽࡎ⌧ᅾㄽᩥᢞ✏୰࡛࠶ࡿ㸦≉チฟ㢪୰㸧㸬NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 13 ᡂศぢฟࡋ㸪ࡑࡢෆࡢ 10 ᡂศࡣ᪂つ≀㉁࡛࠶ࡗࡓ㸬ᖹᡂ 27 ᖺᗘ᪥ᮏ㎰ⱁ໬Ꮫ఍኱఍࡟࡚ࡑࡢᡂᯝࢆⓎ⾲ࡋࡓ㸬ࡲࡓ㸪NMDAཷᐜయ࡟స⏝ࡍࡿ᪂つ࣌ࣉࢳࢻ࡟ࡘ࠸࡚㸪≉チࢆྲྀᚓࡋࡓ㸬࢝ࣉࢧ࢖ࢩࣥཷᐜయ࡟ࡘ࠸࡚ࡶ㸪᪥ᮏ㓇ᡂศ୰࠿ࡽ᪂ࡓ࡟ཷᐜయ࡟స⏝ࡍࡿ࡟ 10 ≀㉁ࢆⓎぢࡋࡓ㸬 ◊✲ィ⏬ ௒ᚋࡶᘬࡁ⥆ࡁ㸪᪥ᮏ㓇࡟ྵࡲࢀࡿ᭷ຠᡂศࡢ⚄⤒⣔ཷᐜయ㸦GABAA ཷᐜయ㸪NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ㸪࢝ࣉࢧ࢖ࢩࣥཷᐜయ㸧࡬ࡢຠᯝࢆ᳨ウࡍࡿ.⤖ᯝ࡟ᇶ࡙ࡁ㸪⚄⤒⣔⣽⬊࡬ࡢ┤᥋ຠᯝࡸ㸪ື≀ᐇ㦂㸦ཷືᅇ㑊ヨ㦂㸪㧗ᯫᘧ༑Ꮠ㏞㊰ヨ㦂㸧ࢆ⾜࠸㸪⚄⤒ᶵ⬟࡬ࡢຠᯝࢆ᳨ドࡍࡿ㸬࠾Ⲕ࡞࡝ࡢ᳜≀⏤᮶ࡢ㤶Ẽᡂศ㸪⏕⌮άᛶ≀㉁ࡢ⚄⤒⣔⣽⬊࡬ࡢຠᯝࢆ᳨ウࡍࡿ
<┠ⓗ> ⣽⬊ࢆ⏝࠸ࡓ་⸆ရ㸪ಖ೺ᶵ⬟㣗ရ࡬ࡢ㛤Ⓨࢆ┠ᣦࡋࡓ㓇ྵ᭷ᡂศ㸪࣌ࣉࢳࢻ㢮㸪ࣅࢱ࣑ࣥ㸪₎᪉ᡂศ࡞࡝⏕⌮άᛶ≀㉁ࡢ᳨⣴ ⌧≧࡜⤖ᯝ ࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ㸪ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥࡢㄏᑟయ㸪⢾㢮ࡢຠᯝࢆ᳨ウࡋࡓ㸬ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ࡜ࡑࡢㄏᑟయཬࡧࣉ࣏ࣟࣜࢫ࡜ࡑࡢྵ᭷ᡂศ࡟⚄⤒ẘཬࡧ㓟໬ࢫࢺࣞࢫ࡟ᑐࡍࡿಖㆤస⏝ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋ㸪ࡑࡢຠᯝ࡟ࡣ⣽⬊≉␗ᛶࡀ࠶ࡿࡇ࡜ࢆⓎぢࡋ㸪27 ᖺᗘ᪥ᮏ㎰ⱁ໬Ꮫ఍኱఍࡟
࡚ࡑࡢᡂᯝࢆⓎ⾲ࡋࡓ㸬◊✲ィ⏬ ௒ᚋࡶࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪⣽⬊ಖㆤస⏝ࢆࡶࡘ≀㉁ࢆぢࡘࡅ㸪ࡑࡢస⏝ᶵᗎࢆ᳨ウࡍࡿணᐃ࡛࠶ࡿ㸬ࣂ࢖࢜ࣉࣛࢫࢳࢵࢡࢆ⏝࠸ࡿ࣮࢝࣎ࣥࢽ࣮ࣗࢺࣛࣝ⏘ᴗ⏝⣲ᮦࡢ㛤Ⓨ㸦ⓑ▼㸪ᒣ⏣㸧<┠ⓗ> ᳜≀⏤᮶⣲ᮦ࣏ࣜங㓟(PLA)࠶ࡿ࠸ࡣኳ↛ࢦ࣒(NR)ࢆ୺ᡂศ࡜ࡋࡓ㧗᳜≀ᗘ࡞⏘ᴗ⏝ᶞ⬡࠶ࡿ࠸ࡣࢦ࣒⣲ᮦࡢ㛤Ⓨ㸦ⓑ▼㸧㸦⌧≧࡜⤖ᯝ㸧᪂つ࡞⤖ᬗ໬ಁ㐍๣࡜ࡋ࡚ࡢ↓ᶵᮦᩱ➼ࡢ㑅ᐃ࡜㓄ྜᢏ⾡࡟ࡼࡾ㸪Ᏻ౯࡛࠿ࡘᑡ㔞ῧຍ࡛ PLA ࡢ≀ᛶᨵၿࡋࡓ㸬NR ࡟▼Ἔ⏤᮶ࡢ࣮࢝࣎ࣥࣈࣛࢵࢡ௦᭰࡜ࡋ࡚ࡢࢭ࣮ࣝࣟࢫࢼࣀࣇ࢓࢖ࣂ࣮(CNF)➼ࡢ㓄ྜ࡟ࡼࡗ࡚㸪⮬ື㌴⏝࢚࢘ࢨ࣮ࢫࢺࣜࢵࣉ࡜ࡋ࡚ᚲ

－ 38 －

せ࡞ࢦ࣒≀ᛶࢆ㐩ᡂࡋࡓ㸬PLA ࡢ♧ࡍඃࢀࡓὶືᛶ࡜◊✲㛤Ⓨ࡟ࡼࡗ࡚ᚓࡓῧຍ๣࡟ࡼࡿ≀ᛶㄪᩚᢏ⾡ࢆ⏝࠸࡚㸪⢭⣽ຍᕤရ⏝㏵࡜ࡋ࡚㸪་⒪⏝㏵ࡢ⾑ᾮ᥇ྲྀ↓③㔪⏝ࡢ⣲ᮦࡸ 3D ࣉࣜࣥࢱ࣮⏝ࡢᶞ⬡࡜ࡋ࡚ࡢᛂ⏝ᒎ㛤ࢆᑕฟᡂᙧᶍᨃᐇ㦂࠿ࡽ㐩ᡂࡋࡓ㸬᫖ᖺᗘࡢ᪂つ࡞⤖ᬗ໬ಁ㐍๣ࡢࡳ࡞ࡽࡎ㸪ຍỈศゎᢚไࡢᶵ⬟ࢆࡶࡘῧຍ๣➼ࡢ㓄ྜ࡟ࡼࡗ࡚㸪ᑕฟᡂᙧ᫬࡟᭱㐺࡞ὶືᛶࢆ୚࠼ࡿ㓄ྜ⣔ࢆ☜❧ࡋࡓ㸬་⒪⏝ࡢ᥇⾑࣭࣡ࢡࢳࣥ᥋✀⏝ࡢ↓③ࣛࣥࢭࢵࢺ࡜ࡋ࡚ࡢࣛࣥࢭࢵࢺ⟂యࡢ඲⏕ศゎᛶࢆ┠ᣦࡋࡓప⎔ቃ㈇Ⲵ⣲ᮦࡢᐇ⏝໬◊✲ࢆᘬࡁ⥆ࡁ⥅⥆ࡋ࡚࠸ࡿ㸬ᚓࡽࢀࡓヨస⟂యࡑࡢࡶࡢࢆ⏝࠸࡚㸪㓝⣲ศゎヨ㦂ཬࡧᅵተศゎヨ㦂ࢆࡑࢀࡒࢀ㓇㢮⥲ྜᢏ⾡◊✲ᡤ࠶ࡿ࠸ࡣ⏘ᴗᢏ⾡⥲ྜ◊✲ᡤࡢᣦᑟ࣭ຓゝࢆཷࡅ࡚ᐇ᪋ࡋ㸪ᚑ᮶ࡢ▼Ἔ⏤᮶࣏ࣜࣉࣟࣆࣞࣥ࡟࡞࠸⏕ศゎᛶࢆ☜ㄆࡋࡓ㸬ࡲࡓ㸪᭱⤊〇ရࡢ⟂యࡢศᯒ࠿ࡽ㸪ࢲ࢖࢜࢟ࢩࣥ➼ࡢⓎ⏕ཎᅉ࡜࡞ࡿሷ⣲ࡀ⌧ᅾ㈍኎ࡋ࡚࠸ࡿ⟂యࡼࡾࡶపࡃࢆぢฟࡋࡓ㸬ࡉࡽ࡟㸪⇕ศゎ GC-MASS ➼ࡢᐃ㝈⏺್௨ୗ࡛࠶ࡿࡇ࡜ᐃ࠿ࡽ㸪᭷ᐖ࡞᥹Ⓨᛶ᭷ᶵ໬ྜ≀ࡢⓎ⏕ࡀṤ࡝࡞࠸ࡇ࡜ࡶ♧ࡋࡓ㸬㸦◊✲ィ⏬㸧⮬ື㌴⏝➼ࡢ⏘ᴗ⏝㏵࡛ࡣ㛤Ⓨ࠿ࡽ࣮ࣘࢨ࣮ࡢせồ࡟࠶ࡗࡓ௙ᵝ࡟᭱㐺࡞㓄ྜࢆ⾜࠸㸪ప౯᱁㸪Ᏻ඲㸪᫆ຍᕤᛶࡢᐇ⏝໬⣲ᮦ࡬࡜ࢩࣇࢺࡋࡓ஦ᴗ໬᳨ウࢆຍ㏿ࡍࡿ㸬ࡲࡓ㸪⏕ศゎᛶᶵ⬟ࢆ฼⏝ࡋࡓ᪂つ࡞࣮ࣘࢨ࣮㛤ᣅࢆ㐍ࡵ᥇⾑⏝↓③㔪➼ࡢ་⒪⏝ᮦᩱ࡬ᛂ⏝ࡉࡽ࡟ࡣ⎔ቃప㈇Ⲵࡢᮏᶞ⬡ࡢ⏝㏵ᣑ኱ࢆ༠ᴗ໬Ꮫၟ♫࡜ඹ࡟㐍ࡵࡿ㸬ࣛࣥࢭࢵࢺ⏝ᶞ⬡࡛ࡣ㸪⁛⳦᧯స࡛ᚲせ࡜࡞ࡿ㧗࢚ࢿࣝࢠ࣮⥺ࡢ↷ᑕ࡟࡜ࡶ࡞࠺≀ᛶ࡬ࡢᙳ㡪ࢆ᳨ウࡍࡿ㸬⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢຠᯝⓗ࡞฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲㸦Ώ㑓㸧<┠ⓗ> ᆅᇦ࡛≉⏘ࡉࢀࡿ㎰Ỉ⏘≀㸪≉࡟ᮍ฼⏝࡞⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢᶵ⬟ࡢ௜ຍ㸪ྥୖ࠾ࡼࡧᨵኚࢆᐇ⌧ࡍࡿࡓࡵࡢ⏕≀໬ᏛᕤᏛⓗࣉࣟࢭࢫࡢᵓ⠏㸦⌧≧࡜⤖ᯝ㸧ᾏⱏ⏤᮶ࣇ࢕ࢥࣅࣜࢱࣥࣃࢡ㉁ࡢỈ⁐ᾮ୰࡛ࡢⰍㄪኚ໬࣓࢝ࢽࢬ࣒ࡀ♧ࡉࢀࡓ㸬ࡲࡓ㸪ᚤ⢊ᮎ໬ᾏⱏࡢᠱ⃮≉ᛶࡢᐃ᪉ἲࡀᥦ᱌ࡉࢀࡓ㸬࢝ࢸ࢟ࣥࡢỈ⣔Ᏻᐃᛶ࡟ཬࡰࡍ࢔ࢫࢥࣝࣅࣥ㓟ࡢ㓟໬ᢚไ࠾ࡼࡧಁ㐍ຠᯝࡀ᳨ウࡉࢀ㸪㏿ᗘㄽⓗゎᯒࢆ㏻ࡋࡓ᳨ドࡀ࡞ࡉࢀࡓ㸬᪻ᕸ࠾ࡼࡧ㫎⠇⏤᮶ࡢ࿴㢼ฟỒㄪ〇࡟࠾ࡅࡿ㤶Ẽᡂศ࡜Ỉ◳ᗘ࡜ࡢ㛵ಀࡀ♧ࡉࢀࡓ㸬ࡲࡓ㸪᳜≀ⴥ࠿ࡽࡢ࢔ࣥࢺࢩ࢔ࢽࣥⰍ⣲ࡢ⮳㐺ᢳฟ᮲௳ࡀỴᐃࡉࢀࡓ㸬෾⤖࣭ゎ෾ࢆ⤒ࡓࣇ࣮ࣞࣂ࣮࣭࢚࣐ࣝࢩࣙࣥࡢᏳᐃᛶホ౯࡛ࡣ㸪Ἔ┦ࡢจᅛⅬ࣭⼥Ⅼ࡜෾⤖࣭ゎ෾ᗘ࡜ࡢ㛵ಀ࡟ᇶ࡙࠸ࡓ୙Ᏻᐃ໬ᶵᗎࡀ♧ࡉࢀࡓ㸬ࣞࣔࣥᯝ⓶ࡢ᭷ຠ฼⏝ἲ๰ฟࡢ᳨ウ࡛ࡣ㸪᭱ࡶ฼⏝ࡀᅔ㞴࡜ࡉࢀࡿ୙⁐ᛶᡂศ࡬ࡢள⮫⏺Ỉฎ⌮ࡢᑟධ࡟ࡼࡿᶵ⬟ᛶࡢᨵၿ࡜ࡑࡢཎᅉ≀㉁ࡢ୍㒊ࡢᥦ♧ࡀ࡞ࡉࢀࡓ㸬㸦◊✲ィ⏬㸧ᚤ⢊ᮎ໬ᾏⱏࡢỈ⣔࡛ࡢศᩓᛶ࡟ᐤ୚ࡍࡿᅉᏊࡢゎ᫂ࢆ┠ᣦࡋ㸪ྠ᫬࡟ⰍㄪᏳᐃᛶ࡜ࡢ㛵ಀ࡟ࡘ࠸᳨࡚ウࡍࡿ㸬ྍ㣗ᛶᢠ㓟໬๣ࡢ㓟໬ᢚไ࣭ಁ㐍㌿᥮Ⅼࡢࡢᐃ࡜㸪ࡑᗘ࣭pH ౫Ꮡᛶࢆ♧ࡋ㸪ᾮ≧㣗ရಖᏑ࡟࠾ࡅࡿᢠ㓟໬๣฼⏝᪉ἲࡢᣦ㔪ࡢᥦ♧ࢆᅗࡿ㸬ᄇ㟝஝⇱ἲ࡟ࡼࡾᚓࡽࢀࡓࣇ࣮ࣞࣂ࣮࣭࣐࢖ࢡࣟ࢝ࣉࢭࣝࡢᏳᐃᛶ࡟ཬࡰࡍ෾⤖࣭ゎ෾ࣉࣟࢭࢫ࡜పಖᏑࡢᙳ㡪࡟ࡘ࠸᳨࡚ウࡍࡿ㸬ࣞࣔࣥᯝ⓶࡞࡝࠿ࡽᢳฟࡉࢀࡓ᭷⏝ᡂศࢆ฼－ 39 －⏝ࡋ࡚㸪ࢰࣝࡲࡓࡣࢤࣝ≧㣗ရ࡜ࡋ࡚ࡢ≀ᛶホ౯ࢆ⾜࠸㸪㐺ᙜ࡞฼⏝ᙧែࢆᶍ⣴ࡍࡿ.
⫢⮚⑓ែࡢస⏝ᶵᗎࡢゎ᫂࡜⫢⮚࡟ᑐࡍࡿᢠ㓟໬≀㉁ࡢస⏝࡟㛵ࡍࡿ◊✲㸦ᑠᕝ㸧<┠ⓗ> ࠶ࡽࡺࡿ⫢⮚⑓ࡢస⏝ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟㸪་⸆ရࡸ㣗ရ࡟ྵࡲࢀࡿᡂศࡢᏳ඲ᛶࡢ᳨ウ࠾ࡼࡧ᪂ࡓ࡞⏕⌮άᛶ≀㉁ࡢⓎぢ㸦ᑠᕝ㸧㸦⌧≧࡜⤖ᯝ㸧ࡇࢀࡲ࡛ࡢ◊✲࡛࣐࢘ࢫࡢ⫢⮚⑓ែࣔࢹࣝࢆస〇ࡋ㸪ࡑࡢ࣐࢘ࢫ࡟ᙉ࠸ᢠ㓟໬స⏝ࢆᣢࡘࣉ࣏ࣟࣜࢫࢆᢞ୚ࡍࡿࡇ࡜࡛⫢⮚ࡢ⬡⫫໬ࡸ⅖⑕ࡀᢚไࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸬ࡑࡇ࡛㸪ᇵ㣴⫢ࡀࢇ⣽⬊࡛࠶ࡿ HepG2 ࡟ࣃ࣑ࣝࢳࣥ㓟ࢆῧຍࡋ㸪⬡⫫ࡢ⵳✚࠾ࡼࡧᑠ⬊యࢫࢺࣞࢫࢆ௓ࡋࡓ࢔࣏ࢺ࣮ࢩࢫࢆㄏᑟࡍࡿ⣽⬊ࣔࢹࣝࢆస〇ࡋࡓ㸬ᐇ㦂࡛ࡣࣃ࣑ࣝࢳࣥ㓟ࢆస⏝ࡉࡏࡓ HepG2 ࡟ࣉ࣏ࣟࣜࢫࢆῧຍࡍࡿࡇ࡜࡟ࡼࡗ࡚ᑠ⬊యࢫࢺࣞࢫ㛵㐃㑇ఏᏊࡢⓎ⌧࠾ࡼࡧ࢔࣏ࢺ࣮ࢩࢫᢚไຠᯝ࡟ࡘ࠸࡚ㄪ࡭ࡓ㸬⤖ᯝ࡜ࡋ࡚㸪HepG2 ࡟ῧຍࡋࡓࣃ࣑ࣝࢳࣥ㓟ࡢ⃰ᗘ౫Ꮡⓗ࡟⣽⬊ᩘࡢῶᑡࡀ☜ㄆ࡛ࡁࡓ㸬ࡲࡓ㸪Oil Red O ᰁⰍ࡟ࡼࡾ㉥ࡃᰁⰍࡉࢀࡓ⬡⫫⵳✚⣽⬊ࡢ๭ྜࡶࣃ࣑ࣝࢳࣥ㓟ࡢ⃰ᗘ౫Ꮡⓗ࡟ቑຍࡋ࡚࠸ࡿࡇ࡜ࡀ
☜ㄆ࡛ࡁࡓ㸬Real-time PCR ࡢ⤖ᯝ㸪ᑠ⬊యࢫࢺࣞࢫ࡟㛵ಀࡍࡿ CHOP㸪GADD34㸪IRE1aࡢ㑇ఏᏊࡀࣃ࣑ࣝࢳࣥ㓟ࡢ⃰ᗘ౫Ꮡⓗ࡟Ⓨ⌧ࡀ᭷ព࡟ቑຍࡋ࡚࠸ࡿࡇ࡜ࡀ☜ㄆ࡛ࡁࡓࡀ㸪࢔࣏ࢺ࣮ࢩࢫ࡟㛵ಀࡍࡿ㑇ఏᏊࡢⓎ⌧ኚ໬ࡣぢࡽࢀ࡞࠿ࡗࡓ㸬ࡇࢀࡽࡢ⤖ᯝ㸪HepG2 ࡟ᑐࡋ࡚ࣃ࣑ࣝࢳࣥ㓟ῧຍ࡟ࡼࡿᑠ⬊యࢫࢺࣞࢫࡢㄏᑟࡀ☜ㄆ࡛ࡁࡓࡀ㸪ࣃ࣑ࣝࢳࣥ㓟ῧຍ 8᫬㛫࡛ࡣ࢔࣏ࢺ࣮ࢩࢫ㛵㐃ࡍࡿ㑇ఏᏊࡢⓎ⌧ኚືࡣぢࡽࢀ࡚࠸࡞࠸ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ㸬ࡲࡓ㸪ࣃ࣑ࣝࢳࣥ㓟ῧຍ࡟ࡼࡗ࡚Ⓨ⌧ࡀୖ᪼ࡋࡓ CHOP㸪GADD34㸪IRE1a ࡢⓎ⌧ࡀࣉ࣏ࣟࣜࢫࡢ⃰ᗘ౫Ꮡⓗ࡟ᢚไࡉࢀࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ㸬௨ୖࡢࡇ࡜࠿ࡽ㸪ࣉ࣏ࣟࣜࢫࡣᑠ⬊యࢫࢺࣞࢫࢆ௓ࡋࡓ HepG2 ࡢ࢔࣏ࢺ࣮ࢩࢫࢆᢚไࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ㸬㸦◊✲ィ⏬㸧ᘬࡁ⥆ࡁୖグࡢヲ⣽࡞ᐇ㦂ࢆ⾜࠸㸪ࣉ࣏ࣟࣜࢫࡢ⫢⮚ࡢ⬡⫫໬ࡸ⅖⑕㸪⥺⥔໬㸪ᑠ⬊యࢫࢺࣞࢫ࡬ࡢᙳ㡪ࢆㄪ࡭ࡿ㸬ࡲࡓ㸪⫢ࡀࢇ⣽⬊ࢆ౑ࡗ࡚⫢⣽⬊ࡢ⬡⫫໬ࡸ⣽⬊Ṛࢆᢚไࡍࡿࣉ࣏ࣟࣜࢫᡂศࡢྠᐃࢆヨࡳࡿ.
㸬ඹྠ◊✲㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸ᖹᡂ 27 ᖺᗘ㸦3 ௳㸸ᅜෆ௻ᴗ㸧2) ᒣ⏣ ᗣᯞ㸸ᖹᡂ 26 ᖺᗘࠕࢢࣝࢱ࣑ࣥ㓟ཷᐜయཬࡧ GABA ཷᐜయ࡟స⏝ࡍࡿ㓇ᡂศ࡟㛵ࡍࡿ◊✲ࠖ㸪⊂❧⾜ᨻἲே 㓇㢮⥲ྜ◊✲ᡤ㸬୺せ࡞◊✲ᴗ⦼  Ꮫ⾡ㄽᩥ㸦 ௳㸧1) ௒ᇛ ᫂඾, ఀ⸨ ኱᫬, ᒣ⏣ ᗣᯞ, ⓑ▼ ᾈᖹ㸪“UCST ᆺࣀࢽ࢜ࣥ⣔࣏࣐࣮ࣜࢆ⾲㠃ಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ HeLa ⣽⬊ࡢᗘ่⃭ࡣࡃ㞳”, ㏆␥኱Ꮫḟୡ௦ᇶ┙ᢏ⾡◊✲ᡤሗ࿌,Vol.6, (2015), pp.55-592) ㎰᐀ ㎮ᕫ㸪௒ᇛ ᫂඾㸪ⓑ▼ ᾈᖹ㸪“ࣉࣛࢬ࣐↷ᑕ㸫࣏ࢫࢺ㔜ྜ࡟ࡼࡿ PNiPAAm ࢢࣛࣇࢺ O2 ᐩ໬⭷ࡢㄪ〇࡜⣽⬊ቑṪ࡟ཬࡰࡍ O2 ౪⤥ࡢᙳ㡪”, 㧗ศᏊㄽᩥ㞟, 72(11),(2015), pp.667-672－ 40 －3) ㎰ ᐀ ㎮ ᕫ 㸪 ௒ ᇛ ᫂ ඾ 㸪 ⓑ ▼ ᾈ ᖹ , “ ⾲ 㠃 㛤 ጞ ཎ Ꮚ ⛣ ື ࣛ ࢪ ࢝ ࣝ 㔜 ྜ ἲ ࡟ ࡼ ࡿPoly(N-isopropylacrylamide)ࡢ࢞ࣛࢫᇶᯈ࡬ࡢᅛᐃ໬࡜ࣄࢺ㛫ⴥ⣔ᖿ⣽⬊(hiMSC)ࡢ
ᗘ่⃭ࡣࡃ㞳”㸪㧗ศᏊㄽᩥ㞟, 72(6), (2015), pp.354-3604) ᒣ⏣ ᗣᯞ㸪ఀ㇋ ⱥᜨ, “᪥ᮏ㓇࠾ࡼࡧ↝㓅ࡢ㤶ࡾ࡜ᶵ⬟ᛶ”, AROMA RESEARCH,16(1), (2015), pp.3-85) ᒣ⏣ ᗣᯞ㸪ቑ⏣ ಟ୍㸪ᒣᮏ ⩧ኴ㸪ఀ㇋ ⱥᜨ, “᪥ᮏ㓇࠾ࡼࡧ↝㓅࡟ྵࡲࢀࡿ㤶Ẽᡂศࡢ⚄⤒⣔ཷᐜయ࡬ࡢຠᯝ”, AROMA RESEARCH, 16(1), (2015), pp.66-736) Yasue Yamada, Kohei Ohtani, Akinori Imajo, Hanae Izu,Hitomi Nakamura, Kohei
Shiraishi, “Comparison of the neurotoxicities between volatile organiccompounds
and fragrant organic compounds on humanneuroblastoma SK-N-SH cells andprimary culturedrat neurons”, Toxicology Reports, Vol.2, (2015), pp.729-736
7) Takahashi N, Watanabe Y, Furutsuka N, Yamamoto T, Okada Y, Nomura M,“Enzymatic saccharification of lemon peel and antioxidative ability of saccharifiedpeel solution”, Agricultural Research Updates, Vol.10, (2015), pp.187-198
8) ᮧୖ ⤖ᇛ, ⸨⏣ ᫂Ꮚ, Ώ㑓 ⩏அ, ᒸ⏣ ⰾ἞, 㔝ᮧ ṇே㸪“⅕㣤Ỉ⵨Ẽ୰࡟ྵࡲࢀࡿ㤶Ẽᡂศ࡜ࡑࡢᢠ㓟໬⬟”, ⨾࿡ᢏ⾡Ꮫ఍ㄅ, 14 (1), (2015), pp.5-109) Watanabe Y, Morishita T, Tojo H, Toriyama E, Watariue N, Yamaguchi R, Nomura
M, “Physicochemical properties of acidic polysaccharides from seaweeds and theirapplication to wheat flour noodle.” Advances in Chemistry Research, 27, (2015),pp.19-3210) Watanabe Y, “Antioxidative properties of acyl ascorbates on lipid oxidation in bulk,disperse and microcapsule systems.” Food Science and Technology Research, 21 (5),(2015), pp.639-64711) Watanabe Y, Adachi S, “Surfactant and antioxidant properties of fatty acid esters
synthesized through lipase-catalyzed condensation with various hydrophiliccompounds.” Emulsifiers: Properties, Functions and Applications, Nova Science
Publishers, Inc. NY, (2016), pp.1-26
  Ꮫ఍Ⓨ⾲㸦 ௳㸧1) Akinori Imajo, Taiji Ito, Kohei Shiraishi, “Preparation Of A UCST Type Of
Thermoresponsive Sulfobetaine Polymer Modified Poly(ethyleneterephthalate)Films By Ar Plasma post Polymerization Method”, The 10th Asian-EuropeeanInternational Conference on Plasma Surface Engineering, (2015.9), Jeju,KOREA2) ⚄ᓮ ᭷ຍ,௒ᇛ ᫂඾, ⓑ▼ ᾈᖹ, “ࢱࣥࣃࢡ㉁⤖ྜ㒊఩࡜ PEG 㙐ࢆᅛᐃ໬ࡋࡓ࣐࢖ࢡࣟ࢔ࣞ࢖ࡢㄪ〇࡜⾑⌫⣔⣽⬊࡜ࣄࢺேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ྵ᭷ᚤᑠ᰾⣽⬊ࡢ⼥ྜ”➨ 64 ᅇ㧗ศᏊᏛ఍ᖺḟ኱఍, (2015.9), ᮐᖠ3) ㎰᐀ ㎮ᕫ, ௒ᇛ ᫂඾, ᒣ⏣ ᗣᯞ, ⓑ▼ ᾈᖹ, “⾲㠃㛤ጞ RAFT 㔜ྜἲ࡛ UCST ᆺᛂ⟅ᛶ࣏࣐࣮ࣜࢆಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ࣄࢺ㛫ⴥ⣔ᖿ⣽⬊(hiMSC)ࢆ⏝࠸ࡓᗘ่⃭ࡣࡃ㞳”, ➨ 64 ᅇ㧗ศᏊᏛ఍ᖺḟ኱఍, (2015.9), ᮐᖠ－ 41 －ᗘ4) ⚄ᓮ ᭷ຍ, ௒ᇛ ᫂඾, ᒣ⏣ ᗣᯞ, ⓑ▼ ᾈᖹ, “PEG ᅛᐃ໬⾲㠃࡛ࡢ⾑⌫⣔⣽⬊࡜ࣄࢺ ேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ྵ᭷ᚤᑠ᰾⣽⬊ࡢ⼥ྜ࡜⣽⬊᥋╔ᣲື”, ➨ 64 ᅇ㧗ศᏊᏛ఍ウㄽ఍, (2015.9), ௝ྎ5) ㎰᐀ ㎮ᕫ, ௒ᇛ ᫂඾, ᒣ⏣ᗣᯞ, ⓑ▼ ᾈᖹ, “⾲㠃㛤ጞ RAFT 㔜ྜἲ࡛ UCST ᆺᗘ ᛂ⟅ᛶ࢔ࢡࣜࣝ࢔࣑ࢻ/࢔ࢡࣜࣟࢽࢺࣜࣝඹ㔜ྜయࢆಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ࣄࢺ㛫ⴥ⣔ᖿ⣽⬊(hiMSC)ࡢ

ᗘ่⃭ࡣࡃ㞳”, ➨ 64 ᅇ㧗ศᏊᏛ఍ウㄽ఍, (2015.9), ௝ྎ6) ᑠᕝ ᬛᘯ㸪ᒣ⏣ ᗣᯞ㸪Ἑ⏣ ๎ᩥ㸪“Propolis components suppresses activated hepatic
stellate cell invasion by inhibition of MMP-2 and MMP-9 expression and its
activation.”, 18th International Symposium on Cells of the Hepatic Sinusoid(ISCHS), (2015.11), Calfornia, U.S.A7) ᒣ⏣ ᗣᯞ㸪ቑ⏣ ಟ୍㸪ᒣᮏ ⩧ኴ㸪ఀ㇋ ⱥᜨ, “᪥ᮏ㓇࠾ࡼࡧ↝㓅࡟ྵࡲࢀࡿ㤶Ẽᡂศࡢ⚄⤒⣔ཷᐜయ࡬ࡢຠᯝ”, ᪥ᮏ㣗ရಖⶶ⛉Ꮫ఍ ๰❧ 40 ࿘ᖺ኱఍ ➨ 64 ᅇ኱఍ ᮾி㎰ᴗ኱Ꮫ, (2015.6), ᮾி8) ᒣ⏣ ⪔㈨㸪ⓑ▼ ᘯ❶㸪ዉዪ Ⰻ᫛㸪᭷㤿 㝧௓㸪㛗ᑿ ṇᓫ㸪ᒣ⏣ ᗣᯞ㸪“ࣄࢺ⚄⤒ⱆ⣽⬊⭘ SK-N-SH ࡬ࡢࢧࣜࣥ㢮ఝ᭷ᶵࣜࣥ๣ࡢẘᛶస⏝” The effect of a sarin-likeorgano-phosphorus agent on human neuroblastoma cell line SK-N-SH”, ➨ 42 ᪥ᮏẘᛶᏛ఍Ꮫ⾡ᖺ఍, (2015.6), 㔠ἑ9) ᒣ⏣ ᗣᯞ㸪▮྿ ᬛ, “NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟ᑐࡍࡿ᪥ᮏ㓇ᡂศࡢຠᯝ”, ➨ 5ᅇ㝔⏕ࢧ࣑ࢵࢺ㸪㏆␥኱Ꮫ࿴ḷᒣ࢟ࣕࣥࣃࢫ㸪(2015.7), ࿴ḷᒣ10) Kosuke Yamada, H Shiraishi, A Namera, Y Arima, M Nagao, Y Yamada, “Theeffect of an organophosphorus agent on human neuroblastoma cell line SK-H-SH”,
International society for Neurochemistry 25th Meeting, (2015.8), Cairns, Australia
11) Tomo Yabuki, K Noritake, Y Uemura, H Izu, Y Yamada, “Effects of components ofsake of GluN1/GluN2A and GluN1/GluN2B subtypes of NMDA receptor.”
International society for Neurochemistry 25th Meeting, Cairns, (2015.8), Australia12) Yasue Yamada, Masashi Nakamichi, “Protective effects of PQQ against the cell
death caused by 6-hydroxydopamine and hydrogen peroxide”, Society forNeuroscience 45th Annual Meeting 2015, (2016.10), Chicago, U.S.A.
13) すᒃ ࿴ဢ, ୰㊰ ᫀᚿ, 㔝ᮧ ᏹᇶ, ஂಖ ⯟኱, ᘏ㇂ ┤ဢ, ୰す ្, ᒣ⏣ ᗣᯞ, “ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ࡜࢖࣑ࢲࢰࣆࣟࣟ࢟ࣀࣜࣥࡢ SK-N-SH ⣽⬊࡜ HepG2 ⣽⬊࡟ᑐࡍࡿຠᯝࡢẚ㍑᳨ウ”, ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2016 ᖺᗘ኱఍, (2016.3), ᮐᖠ14) ▮྿ ᬛ, ๎ໟ ₩ே, ୖᮧ ຬ㈗, ఀ㇋ ⱥᜨ, ᒣ⏣ ᗣᯞ, “NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟ᑐࡍࡿ᪥ᮏ㓇ᡂศࡢຠᯝ”, ᪥ᮏ㎰ⱁ໬Ꮫ఍ 2016 ᖺᗘ኱఍, (2016.3), ᮐᖠ15) Watanabe Y, Kono Y, Hiroshima M, Adachi S, “Stability of oil-in-water
emulsioncontaining flavor component through freezing and thawing processes”,
12th International Congress on Engineering and Food, (2015.6), Quebec, Canada16) ᯘ ᓫ⿱㸪㧗ᶫ ⯟㸪Ώ㑓 ⩏அ㸪㧗ὠ ᆅᚿ㸪⸨⏣ ᫂Ꮚ㸪㔝ᮧ ṇே㸪“⅕㣤⡿⁐ฟᛶ⃦⢊ࡢ≉ᛶホ౯ࡢࡓࡵࡢ in vitro ᾘ໬ヨ㦂”㸪➨ 16 ᅇ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍㸪(2015.8)㸪
ᗈᓥ－ 42 －17) Ἀཎ ᆂ♸㸪ᯇᾆ ຬኴ㸪Ώ㑓 ⩏அ㸪“ࣞࣔࣥᯝ⓶୙⁐ᛶᡂศࡢỈ⇕ฎ⌮࡟ࡼࡿࡑࡢᶵ⬟ᛶ࡬ࡢᙳ㡪”㸪➨ 16 ᅇ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍, (2015.8), ᗈᓥ18) ዟᯘ Ꮥᩥ㸪ᘯᔱ ┿ឡ㸪Ώ㑓 ⩏அ㸪“෾⤖࣭ゎ෾ᚋࡢ O/W ᆺ࢚࣐ࣝࢩࣙࣥ࡜ྵ᭷ࣇ࣮ࣞࣂ࣮ࡢᏳᐃᛶ”㸪➨ 16 ᅇ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍㸪(2015.8), ᗈᓥ19) すཎ ᗣḟ㑻㸪ᮌ඲ ಇ௓㸪Ώ㑓 ⩏அ㸪“ᾏⱏࣇ࢕ࢥࣅࣜࢱࣥࣃࢡ㉁Ỉ⁐ᾮࡢⰍᏳᐃᛶ࡜㓝⣲ฎ⌮࡟ࡼࡿⰍㄪᨵ㉁”㸪➨ 16 ᅇ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍㸪(2015.8)㸪ᗈᓥ20) ᫓᦬ ಇ㈗㸪ⴗ㔝 㔛㑣㸪Ώ㑓 ⩏அ㸪“᪻ᕸ࠾ࡼࡧ㫎⠇ࢆ⏝࠸ࡓ࿴㢼ฟỒࡢᛶ㉁࡟ཬࡰࡍỈࡢ◳ᗘࡢᙳ㡪”㸪➨ 16 ᅇ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍㸪(2015.8), ᗈᓥ21) ᶓ㔝 ୍Ṍ㸪㧗ὠ ᆅᚿ㸪⸨⏣ ᫂Ꮚ㸪ᒸ⏣ ⰾ἞㸪Ώ㑓 ⩏அ㸪㔝ᮧ ṇே㸪“⡿㣤୰ࡢ࢜ࣜࢦ⢾ྵ᭷㔞࡜㣗࿡ࡢ㛵ಀ”㸪᪥ᮏ㎰ⱁ໬Ꮫ఍ 2015 ᖺᗘ୰ᅄᅜ࣭す᪥ᮏᨭ㒊ྜྠ኱఍㸦୰ᅄᅜᨭ㒊➨ 43 ᅇㅮ₇఍࣭す᪥ᮏᨭ㒊➨ 312 ᅇㅮ₇఍㸧㸪(2015.9), ឡ፾22) ᶓ㔝 ୍Ṍ㸪㧗ὠ ᆅᚿ㸪⸨⏣ ᫂Ꮚ㸪Ώ㑓 ⩏அ㸪ᒸ⏣ ⰾ἞㸪㔝ᮧ ṇே㸪“⅕㣤᮲௳࡟࠾ࡅࡿ࿊࿡ᡂศࡢኚ໬࡜㣗࿡ࡢ㛵ಀ”㸪᪥ᮏ㎰ⱁ໬Ꮫ఍ 2016 ᖺᗘ኱఍㸪(2016.3), ᮐᖠ  ㅮ₇㸦 ௳㸧1) ⓑ▼ ᾈᖹ, “⣽⬊⼥ྜ࣭ᅇ཰⮬ື໬⿦⨨”, ࣁ࢖ࢸࢡศ㔝ࣅࢪࢿࢫ࣐ࢵࢳࣥࢢ in ᗈᓥ㸪
㏆␥኱Ꮫḟୡ௦ᇶ┙ᢏ⾡◊✲ᡤ㸦ᮾᗈᓥ㸧㸪2016.2.172) ⓑ▼ ᾈᖹ, “㧗⢭ᗘ఩⨨Ỵࡵ࣮ࣞࢨ࣮ග↷ᑕ࡟ࡼࡿ⣽⬊⼥ྜ⿦⨨ࡢ㛤Ⓨ”, 2015 ࣅࢪࢿࢫ࣐ࢵࢳࣥࢢ஺ὶ఍㸪ᗈᓥࢢࣛࣥࢻ࢖ࣥࢸࣜࢪ࢙ࣥࢺ࣍ࢸࣝ㸦ᗈᓥ㸧, 2016.1.28
3) ᒣ⏣ ᗣᯞ㸪“᪥ᮏ㓇࡟ྵࡲࢀࡿ᭷ຠᡂศ” ㏆␥኱ᏛᕤᏛ㒊◊✲බ㛤ࣇ࢛࣮࣒ࣛ 2015 ◊✲Ⓨ⾲㸦ᗈᓥ㸧㸪2015.10.264) ᒣ⏣ ᗣᯞ, “ࢢࣝࢱ࣑ࣥ㓟ཷᐜయάᛶࢆࡶࡘ᪂ࡓ࡞ࢪ࣌ࣉࢳࢻཬࡧ GABAA ཷᐜయάᛶࢆࡶࡘ᭷ᶵ㓟” ㏆␥኱Ꮫ᪂ᢏ⾡ㄝ᫂఍ ୺ദ㸸㏆␥኱Ꮫ㸪ᅜ❧◊✲㛤Ⓨἲே ⛉Ꮫᢏ⾡᣺⯆ᶵᵓ㸪ᮾி⛉Ꮫᢏ⾡᣺⯆ᶵᵓ ᮾிᮏ㒊ู㤋, 2015.7.16
  ≉チฟ㢪㸦 ௳㸧1)ⓑ▼ᾈᖹ㸸1 ௳ ≉チⓏ㘓㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸪ᒣ⏣ ᗣᯞ௚㸸⣽⬊⮬ືศྲྀ⿦⨨ཬࡧ⣽⬊⮬ືศྲྀ᪉ἲ㸪≉チ➨ 5765763 ྕ2) ⓑ▼ ᾈᖹ㸪ᒣ⏣ ᗣᯞ௚㸸ࢭࣝ࢔ࣞ࢖ࢯ࣮ࢱ㸪ࡑࡢ〇㐀᪉ἲཬࡧ⣽⬊ࢯ࣮ࢺ᪉ἲ㸪 ≉チ➨ 5780511 ྕ3) ᒣ⏣ ᗣᯞ㸸་⸆⤌ᡂ≀ ≉チ➨ 5747397 ྕ  ࡑࡢ௚㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸௻ᴗ➼ᢏ⾡ᣦᑟ㸦12 ௳㸧2) ⓑ▼ ᾈᖹ㸸ᖹᡂ 27 ᖺᗘ⤒῭⏘ᴗ┬ᡓ␎ⓗᇶ┙ᢏ⾡㧗ᗘ໬᥎㐍஦ᴗ⿵᏶◊✲ሗ࿌᭩3) ⓑ▼ ᾈᖹ㸸ጤク◊✲ሗ࿌᭩㸦4 ௳㸧

－ 43 －4) ᒣ⏣ ᗣᯞ㸪ቑ⏣ ಟ୍㸪ᒣᮏ ⩧ኴ㸪ఀ㇋ ⱥᜨ, “᪥ᮏ㓇࠾ࡼࡧ↝㓅࡟ྵࡲࢀࡿ㤶Ẽᡂศࡢ⚄⤒⣔ཷᐜయ࡬ࡢຠᯝ”, AROMA RESEARCH 16(1),66-73(2015) 2015 ᖺᗘㄽᩥ㈹ཷ㈹㸬እ㒊㈨㔠⋓ᚓ㸦 ௳㸧࠙➇தⓗ㈨㔠ࠚ1) Ώ㑓 ⩏அ㸸⛉Ꮫ◊✲㈝ ᇶ┙◊✲(C)ࠕ㣗ရ࡜ࡋ࡚ࡢ⬡㉁ࡢ㧗ᗘ฼⏝࡜ࡑࡢရ㉁ຎ໬ᶵ
ᵓࡢゎ᫂ࠖ㸦௦⾲⪅㸧ᖹᡂ 26㹼28 ᖺᗘ2) Ώ㑓 ⩏அ㸸Ꮫ⾡◊✲ຓᡂ බ㈈ 㣤ᓥ⸨༑㑻グᛕ㣗ရ⛉Ꮫ᣺⯆㈈ᅋࠕᚤ⢊ᮎ໬ᾏⱏࡢⰍㄪᏳᐃ໬ࡢࡓࡵࡢⰍ⣲ࢱࣥࣃࢡ㉁ࡢ≉ᛶゎᯒࠖ㸦௦⾲⪅ 3) Ώ㑓 ⩏அ㸸ᖹᡂ 27 ᖺᗘ◊✲ຓᡂ බ㈈ ᪥ᮏ㣗ရ໬Ꮫ◊✲᣺⯆㈈ᅋࠕỈ⣔㣗ရ୰ࡢ࢔ࢫࢥࣝࣅࣥ㓟࡜ࡑࡢ࢔ࢩࣝㄏᑟయࡢ㓟໬ಁ㐍࠾ࡼࡧᢚไస⏝ᶵᗎࡢゎ᫂ࠖ㸦௦⾲⪅ 4) Ώ㑓 ⩏அ㸸ᖹᡂ 27 ᖺᗘ◊✲ຓᡂ බ㈈ ࢯࣝࢺ࣭ࢧ࢖࢚ࣥࢫ◊✲㈈ᅋࠕሷࡀ࿴㢼ฟỒࡢ᪨࿡࠾ࡼࡧ㤶Ẽᡂศ࡟ཬࡰࡍᙳ㡪ࠖ㸦௦⾲⪅ 5) Ώ㑓 ⩏அ㸸ᖹᡂ 27 ᖺᗘ኱Ꮫ◊✲ຓᡂ බ㈈ ࢧࢱࢣᢏ⾡᣺⯆㈈ᅋࠕࣞࣔࣥᯝ⓶⏤᮶୙⁐ᛶᡂศࡢỈ⇕ฎ⌮࡜ࡑࡢ⏕ᡂ≀ࡢ㣗ရ฼⏝ࠖ㸦௦⾲⪅6) ᑠᕝ ᬛᘯ㸸⛉Ꮫ◊✲㈝ ⱝᡭ◊✲(B)ࠕ⫢⥺⥔໬㒊఩࡟㞟✚ࡍࡿ➽⥺⥔ⱆ⣽⬊࡟ࡼࡿ⥺⥔ᙧᡂࡢศᏊᶵᵓ࡟㛵ࡍࡿᇶ♏ⓗ◊✲ࠖ ௦⾲⪅ ᖹᡂ26ࠥ27ᖺᗘ7) ᑠᕝ ᬛᘯ㸸㸦බ㈈㸧ྂᕝᢏ⾡᣺⯆㈈ᅋ◊✲ຓᡂࠕ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖(NASH)ࡢ
⡆᫆ⓗ࡞デ᩿ἲࡢ㛤Ⓨ࡜ࡑࡢ἞⒪ࢆ┠ⓗ࡜ࡋࡓ⣽⬊࢟ࢵࢺࡢ㛤Ⓨࠖ ௦⾲⪅ ᖹᡂ27ᖺᗘ࠙Ꮫෆ◊✲ຓᡂ㔠ࠚ1) ᒣ⏣ ᗣᯞ㸸㏆␥኱Ꮫ 21 ୡ⣖◊✲㛤Ⓨዡບ㔠㸦ᖹᡂ 26㹼28 ᖺ㸧㸦௦⾲⪅:⏘ᴗ⌮ᕤᏛ㒊⸨஭ ᨻᖾᩍᤵ㸧࠙ᐤ㝃࣭ጤク◊✲㈝ࠚ1) ⓑ▼ ᾈᖹ㸸௦⾲⪅㸦7 ௳㸧2) ᒣ⏣ ᗣᯞ㸸ཷク◊✲㸦1௳㸧3) ᑠᕝ ᬛᘯ㸸◊✲ຓᡂ㔠㸦බ㈈㸧ྂᕝᢏ⾡᣺⯆㈈ᅋࠕ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖(NASH)ࡢ⡆᫆ⓗ࡞デ᩿ἲࡢ㛤Ⓨ࡜ࡑࡢ἞⒪ࢆ┠ⓗ࡜ࡋࡓ⣽⬊࢟ࢵࢺࡢ㛤Ⓨࠖ㸦௦⾲⪅ 㸬Ꮫእවົᴗົ1) ⓑ▼ ᾈᖹ㸸㸦බ♫㸧㧗ศᏊᏛ఍୰ᅜᅄᅜᨭ㒊ᖿ஦ᗈᓥ኱Ꮫ୺ദ⎔ቃඹ⏕ࢫ࣐࣮ࢺᮦᩱ◊✲ᣐⅬ࣓ࣥࣂ࣮2) ᒣ⏣ ᗣᯞ㸸᪥ᮏ㣗ရ࣭ᶵᲔ◊✲఍ ⌮஦᪥ᮏ⸆⌮Ꮫ఍ ホ㆟ဨ3) Ώ㑓 ⩏அ㸸୍♫ ᪥ᮏ㣗ရᕤᏛ఍ᖺḟ኱఍ᐇ⾜ጤဨ－ 44 －4) ᑠᕝ ᬛᘯ㸸බ❧኱Ꮫἲே኱㜰ᕷ❧኱Ꮫ ᐈဨ◊✲ဨ㸬ࡑࡢ௚ͤ◊✲ᣦᑟ1) ⓑ▼ ᾈᖹ㸪ᑠᕝ ᬛᘯ㸪㕥ᮌ ཌ㸸රᗜ┴❧㉥✑ᕷ❧᭷ᖺ୰Ꮫᰯ ᩍ⫱㐃ᦠᤵᴗࠕ෌⤖ᬗࠖࠕ࢚࢝ࣝࡢཷ⢭༸ࡢほᐹࠖᖹᡂ 27 ᖺ 8 ᭶ 9-10 ᪥－ 45 －