第 25 回 ⽇本 RNA 学会年会 ポスター発表
Poster Presentations of the 25th RNA Japan Meeting in TOKYO
ポスターセッション (1) 奇数番号発表（Odd numbers） 6 ⽉ 26 ⽇(⽔曜⽇) 13:00-14:30
ポスターセッション (2) 偶数番号発表（Even numbers）6 ⽉ 27 ⽇(⽊曜⽇) 13:00-14:30㊫ : 筆頭著者が学⽣会員 First author is student member
P-001 (EMBO Poster Clinic)
Deep learning based end-to-end classification and absolute quantificationof E. Coli cellular tRNAs using nanopore sequencing○ Bhaskar Dasgupta1, Mai Maeda2, Ryo Noguchi 2, Tsutomu Suzuki2, Hiroki
Ueda1(1RCAST, Univ. of Tokyo, 2Dept. of ChemBio., Sch. of Eng., Univ. of Tokyo)㊫

P-002 (EMBO Poster Clinic)
Structural optimization of tRNA anticodon stem toward translational
synthesis of natural nonribosomal peptides○Ryoichi Hirashima1, Takayuki Katoh1, Hiroaki Suga1(1 Department of Chemistry, Graduate School of Science, The University ofTokyo)
P-003 (EMBO Poster Clinic)
Extracellular biomolecule-responsive translational regulation system forsynthetic mRNAs○Hideyuki Nakanishi1, 2 and Keiji Itaka1, 2(1 Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental
University, 2 Center for Infectious Disease Education and Research (CiDER),
Osaka University)

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P-004 (EMBO Poster Clinic)
Exploring a Nucleoprotein Origin of Life through Ribozyme-Assisted In
Vitro Evolution of Protein Polymerases○ Riddhi Gondhalekar1,2, Shunsuke Tagami3, Sota Yagi4, Kosuke Fujishima1,2,5(1School of Life Science and Technology, Tokyo Institute of Technology; 2EarthLife Science Institute, Tokyo Institute of Technology; 3RIKEN BDR; 4Faculty of
Human Sciences, Waseda University; 5Graduate School of Media andGovernance, Keio University)㊫

P-005 (EMBO Poster Clinic)
Physiological roles of tRNA modification in myoblast differentiation○Tsaijung Liu1, Mayuko Takakura2, Yuta Noda2, Shinichiro Akichika2, Shintaro
Iwasaki3, and Tsutomu Suzuki1, 2(1Department of Bioengineering, School of Engineering, The University of Tokyo,
2

Department of Chemistry and Biotechnology, School of Engineering, The

University of Tokyo, 3The Institute of Physical and Chemical Research (RIKEN))
P-006 (EMBO Poster Clinic)
Recognition and Deubiquitination of Ribosomes for Next RoundTranslation○Ken Ikeuchi1,2,3, Nives Ivic4, Robert Buschauer1, Jingdong Cheng1, Thomas
Fröhlich1, Yoshitaka Matsuo5, Otto Berninghausen1, Toshifumi Inada5, Thomas
Becker1, Roland Beckmann1(1 Gene Center Munich, University of Munich LMU, Germany, 2 Frontier ResearchInstitute for Interdisciplinary Sciences, Tohoku University, 3 Institute ofMultidisciplinary Research for Advanced Materials, Tohoku University, 4
Department of Physical Chemistry, Rudjer Boskovic Institute, Croatia, 5 Instituteof Medical Science, The University of Tokyo)-2-P-007 (EMBO Poster Clinic)
Group A streptococcus selectively manipulates host translation○Hirotaka Toh1, Takashi Nozawa2, Ichiro Nakagawa2, and Shintaro Iwasaki1,3(1 RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering
Research,2 Department of Microbiology, Graduate School of Medicine, Kyoto
University,3 Department of Computational Biology and Medical Sciences,
Graduate School of Frontier Sciences, The University of Tokyo)㊫

P-008 (EMBO Poster Clinic)
Regulatory Mechanisms of A-to-I RNA Editing: Modulating Protein
Synthesis through Translation Initiation Signals in the 5′-UTR○Yuki Ogata1, Masatora Fukuda1, 2(1Dept. Chem., Graduate School of Science, Fukuoka Univ. 2Dept. Chem., Fac.
Sci., Fukuoka Univ.)㊫

P-009 (EMBO Poster Clinic)
The Analysis of Uncapped mRNA Transcriptome in Trypanosoma Parasites○Kieu DM Nguyen1, Yuko Takagi2, and C. Kiong Ho1,3(1Human Biology Program, University of Tsukuba, 2 National Institute ofAdvanced Industrial Science and Technology, 2 Institute of Medicine, Universityof Tsukuba)㊫

P-010 (EMBO Poster Clinic)
SUMOylated Senataxin suppresses transposable elements in the
Drosophila Piwi-piRNA pathway○Rin Imai, Yaning Wu, Haruhiko Siomi, Kensaku Murano(Department of Molecular Biology, Keio University School of Medicine Japan)-3-P-011 (EMBO Poster Clinic)
Elucidation of the role of the N-terminal prion-like domain of SGS3 inplant secondary siRNA biogenesis○Yuji Fujimoto1, Yuriki Sakurai1, Keisuke Shoji2, Manabu Yoshikawa3, and Hirooki Iwakawa1(1 College of Science, Rikkyo University, 2 Graduate School of Bio-Applications
and Systems Engineering, Tokyo University of Agriculture and Technology, 3
Division of Plant and Microbial Sciences, Institute of Agrobiological Sciences,
National Agriculture and Food Research Organization)㊫

P-012 (EMBO Poster Clinic)
The regulation of persistent Borna disease virus infection by RNAsilencing factors in human cells○Yuui Naito1, Yuka Kaneko1, Rie Koide2,3, Nicholas F. Parrish2,3, Tomoko
Takahashi1(1Graduate School of Science and Engineering, Saitama University, 2Genome
Immunobiology RIKEN Hakubi Research Team, Cluster for Pioneering Research,
RIKEN, 3Center for Integrative Medical Sciences, RIKEN)
P-013 (EMBO Poster Clinic)
Short-term metatranscriptional response to warming and cooling of the
microbiome in Alaskan permafrost measured by on-site RNA extraction
Lan Anh Catherine Nguyen1,2, Go Iwahana3, Kenjiro Tadakuma4, ○Josephine
Galipon1,5(1Institute for Advanced Biosciences, Keio University, Japan, 2 Systems Biology
Program, Graduate School of Media and Governance, Keio University, Japan,
3International Artic Research Center (IARC), University of Alaska Fairbanks,

USA, 4Graduate School of Engineering Science, Osaka University, Japan,
5

Graduate School of Science and Engineering Yamagata University, Japan)

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P-014 (EMBO Poster Clinic)
Molecular mechanism of tRNA hydroxylation and its pathophysiologicalroles○Xu Yue1, Kotaro Tomuro2,3, Shintaro Iwasaki2,3, Akiko Ogawa1, Fan-Yan Wei1
(1 Department of Modomics Biology and Medicine, Institute of Development,
Aging and Cancer, Tohoku University, Sendai, Miyagi, 980-8575, Japan, 2 RNA
Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako,
Saitama, 351-0198, Japan, 3 Department of Computational Biology and Medical
Sciences, Graduate School of Frontier Sciences, The University of Tokyo,
Kashiwa, Chiba 277-8561, Japan.)㊫

P-015 (EMBO Poster Clinic)
Enzymatic Characteristics of Mycoplasma Membrane Nuclease mnuA
○Katsuki Aoyama1, Yoshika Takenaka1, Yoshihisa Tomioka1 and Yasutoshi
Akiyama1(1 Department of Pharmaceutical Sciences, Tohoku University)
P-016 (EMBO Poster Clinic)
A potential role of inefficient and non-specific piRNA production from thewhole transcriptome○Keisuke Shoji1,2,3, Jie Yu1, Natsuko Izumi1, Yukihide Tomari1,2(1Laboratory of RNA Function, Institute for Quantitative Biosciences, The
University of Tokyo, 2Department of Computational Biology and Medical
Sciences, Graduate School of Frontier Sciences, The University of Tokyo,
3

Graduate school of Bio-Applications and Systems Engineering, Tokyo Universityof Agriculture and Technology)

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P-017
Thermodynamic and Structural Impacts of Chemical Modifications in thesiRNA Seed Region on Off-Target Effects○ Seongjin An1, Yoshiaki Kobayashi2, Kohei Nomura3, Yasuaki Kimura3, Hiroshi
Abe3, Akase Dai4, Misako Aida5, Kumiko Ui-Tei1,2(1Graduate School of Frontier Sciences, The University of Tokyo, 2Graduate
School of Science, The University of Tokyo, 3Graduate School of Science, Nagoya
University, 4AIDI Center, Hiroshima University, 5Office of Research andAcademia-Government-Community Collaboration, Hiroshima University)

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P-018
Interferon-inducible ADAR1p150-mediated regulation of gene expression
network through microRNA○Toyotaka Yoshida1, Yoshimasa Asano 1,2, Shota Azuma1, Kumiko Ui-Tei 1(1 Graduate School of Science, The University of Tokyo, 2 School of Pharmacy,
Nihon University)

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P-019
siRNAs discriminate single nucleotide differences in PIK3CA○Toshinori Ohyama1, Yoshiaki Kobayashi2, Yoshimasa Asano2, Susumu
Goyama1, Kumiko Ui-Tei1,2(1Department of Computational Biology and Medical Sciences, Graduate Schoolof Frontier Science, The University of Tokyo, 2Department of Biological Sciences,
Graduate School of Science, The University of Tokyo)

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P-020
Structural and functional analysis of antiphage defense mechanism in thetype III-D2 CRISPR-Cas system○Yoshihisa Mitsuda1, Junichiro Ishikawa1, Masahiro Hiraizumi1,2, Keitaro
Yamashita1,2 and Hiroshi Nishimasu1,2(1 Graduate School of Engineering, The University of Tokyo, 2 Reserch Center for
Advanced Science and Technology, The University of Tokyo)

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P-021
Paip1 represses translation in a PABP dependent manner○Kanae Miyazaki1, Takumi Tomohiro1, Akira Fukao1, Tomohiko Aoyama1 Yuichi
Shichino2, Shintaro Iwasaki2, Toshinobu Fujiwara1(1Kindai University, 2RIKEN)
P-022
Recent Progress of High-Throughput Mutational Analysis for RNA
Methylation
Ryota Yamagami, Hina Kubota, Emi Kohno, and ○Hiroyuki Hori
(Graduate School of Science and Engineering, Ehime University, Japan)

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P-023
Mutation analysis of a novel domain of ZRSR2 - a responsible geneproduct in myelodysplastic syndrome.
○Tomoki Chiba1, Eri Matsumoto1, So Masaki 1, Satoshi Tanaka1 and Naoyuki
Kataoka1(1. The University of Tokyo)
P-024
Four-way Decoding with Unmodified Uridine at the Wobble Position in
Lactic Acid Bacteria○Chie Tomikawa1, Riko Sugita1, Vincent Guérineau2, David Touboul2, Satoko
Yoshizawa3, and Kazuyuki Takai1(1 Graduate School of Science and Engineering, Ehime University, 2 ICSN, CNRSUPR 2301, Université Paris-Saclay, 3 LBPA, CNRS UMR8113, ENS Paris-Saclay,
Université Paris-Saclay)

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P-025
Identify the effect of R-loop on transcriptional regulatory mechanisms○Ryotaro Yanoshita1 , Eito Ichihashi1, Mai Kubota1, Chao Zeng2, Michiaki
Hamada2, Masayuki Sakurai3(1 Graduate School of Biological Sciences, Tokyo University of Science, 2Waseda
University Hamada Laboratory, 3Research Institute for Biological Science, Tokyo
University of Science)
P-026
Dissection of stop codon recognition by mammalian mitochondrial peptide
release factors by an in vitro reconstituted mammalian mitochondrialtranslation system○Muhoon Lee, Yutong Zhang, Ruiyuan Huang, Nono Takeuchi-Tomita(Department of Computational Biology and Medical Sciences, Graduate School of
Frontier Sciences, University of Tokyo)

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P-027
A possible mechanism for the mutually exclusive formation of U-bodies
and stress granules○Kantaro Sugi1, Shinichi Nakagawa1,2, Hiroshi Maita1,2(1Graduate school of life science, Hokkaido University, 2Faculty of pharmaceuticalsciences, Hokkaido University)
P-028
Mechanism of cancer malignancy via chronic inflammation mediated by
YAP/TAZ through RNA hierarchy○Tomoki Chiba1, Hiroshi Asahara1(1 Department of Systems BioMedicine, Tokyo Medical and Dental University(TMDU))

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P-029
Development of practical purification methods for circular mRNA
○Kosuke Fukuchi1, Shiryu Kajihara1, Naoko Abe1, Fumitaka Hashiya2, Hiroshi
Abe1,3(1Grad. Sch. of Sci., Nagoya Univ., 2RCMS, Nagoya Univ., 3iGCORE.)
P-030
Roles of SECIS binding protein 2 (SBP2) in selenoprotein synthesis andneuronal function
Takako Furukawa, ○Yoshika Hayakawa-Yano, Azusa Kondo and Masato Yano
(Graduate School of Medical and Dental Sciences, Niigata University)
P-031
C-terminal IDR domain of ESS2 regulates prostate cancer proliferation○Ichiro Takada1, Makoto Makishima2, Tohru Nakagawa3, Sayuri Takahashi1(1Department of Urology, The Institute of Medical Science, The University ofTokyo, 2Division of Biochemistry, Department of Biomedical Sciences, School of
Medicine, Nihon University, 3Department of Urology, Teikyo University School of
Medicine)
P-032
Integrating mRNA-LNP Platforms with Antibody Engineering in Drug
Development○Shun Shimizu1, Hikaru Koga1, Naoya Miura1, Kazuki Sato1, Haruno Onuma1,
Zenjiro Sampei1(1 Discovery Biologics Dept., Chugai Pharmaceutical Co., Ltd.)

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P-033
Deciphering the relationship between 5'UTR and 3'UTR sequence ofmRNA○Kanta Suga1, Michiaki Hamada1,2,3,(1 Faculty of Science and Engineering, Waseda university, 2. Computational Bio
Big-data Open Innovation Laboratory (CBBD-OIL), 3.National Institute ofAdvanced Industrial Science And Technology (AIST))-9-

P-034
Two secondary structures in SARS-CoV-2 3ʼ UTR controlling genome
replication○Takako Ohyama1, Takuo Osawa1, Shun-ich Sekine1, Yoshitaka Ishii1,2(1Center for Biosystems Dynamics Research, RIKEN, 2School of Life Science andTechnology, Tokyo Institute of Technology)㊫

P-035
Relationship between stress granule and microRNA-mediated translation
repression using stress granule formation factor○Mai Miyao1, Ayumi Mori1, Takumi Tomohiro1, Akira Fukao1, Shungo Adachi2,3,
Tohru Natsume3, Koji Onomoto4, Mitsutoshi Yoneyama4, Toru Suzuki5, Tadashi
Yamamoto6 and Toshinobu Fujiwara1(1. Kindai University, 2. National Cancer Center, 3. AIST , 4. Chiba University,
5. IMSUT, 6. OIST)

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P-036
Exploration and functional analysis of circRNAs regulating inflammatory
responses○Shuya Hiroki1, Daisuke Ori1, Norisuke Kano1, Taro Kawai1(1 Laboratory of Molecular Immunobiology, Graduate School of Science andTechnology, Nara Institute of Science and Technology (NAIST))

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P-037
Structural and Functional Analyses of Cwf19L1 Protein, a Responsible
Gene Product for SCAR17○Ryota Furukawa1, So Masaki1, Satoshi Tanaka1 and Naoyuki Kataoka1(1 The University of Tokyo)- 10 -

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P-038
Pseudouridine in the middle of tRNA anticodon facilitates genetic code
alteration in arthropod mitochondria○Naho Akiyama1, Kazuki Inoue1, Kenjyo Miyauchi1, Kensuke Ishiguro1, Shinichi
Yokobori2, Makoto Ihara3, Kimitsuna Watanabe2, and Tsutomu Suzuki1(1Dept. of Chem.&Biotech., Grad. Sch. of Eng., UTokyo, 2Tokyo Univ. of Pharm.
and Life Sci., 3Radioisotope Medicine, Nagasaki Univ.)

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P-039
Gene expression alteration in HTLV-1 infected cells by a METTL3/14
inhibitor STM2457○Rei Higa, Kaoru Uchimaru, Makoto Yamagishi(Graduate School of Frontier Sciences, The University of Tokyo)
P-040
Development of a strategy to fine-tune the efficiency of mRNA translation
based on tRNA modifications○Daisuke Ando1,2,3, Sherif Rashad1,4, Thomas J Begley5, Peter C Dedon6, andKuniyasu Niizuma1,3,4,7(1Department of Neurosurgical Engineering and Translational Neuroscience,
Tohoku University Graduate School of Medicine; 2Department of Neurology,
Tohoku University Graduate School of Medicine; 3Division of Development andDiscovery of Interventional Therapy, Tohoku University Hospital; 4Department of
Neurosurgical Engineering and Translational Neuroscience, Graduate School of
Biomedical Engineering, Tohoku University; 5Department of Biological Sciences,
University at Albany; 6Department of Biological Engineering, Massachusetts
Institute of Technology; 7Department of Neurosurgery, Tohoku University
Graduate School of Medicine)- 11 -

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P-041
Crucial roles of the RNA helicase DDX6 in the maintenance of alveolar
macrophages○Asako Kajiya1, Chihiro Goya1, Ting Cai1, Yoshinaga Masanori1, Michael C
Bassik2, Osamu Takeuchi1(1Department of Medical Chemistry, Graduate School of Medicine, Kyoto
University, 2Department of Genetics, Stanford University)

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P-042
SSA and EFGR pathway inhibitors cause dephosphorylation of PUM1 andstabilize p27 mRNA.
○Mayuko Hotta1, Midori Shima1, Fuku Matsuda1, Daisuke Kaida1(1 School of Medicine, University of Toyama)
P-043
Editing of the polyubiquitin architecture on the collided ribosome
maintains persistent RQC activity
Shota Tomomatsu1,2, ○Yoshitaka Matsuo1, Fumiaki Ohtake2, Takuya Tomita3,
Yasushi Saeki3,4, Toshifumi Inada1.
(1Division of RNA and Gene regulation, Institute of Medical Science, The
University of Tokyo, 2Institute for Advanced life Sciences, Hoshi University,
3

Division of protein metabolism, Institute of Medical Science, The University ofTokyo, 4Protein Metabolism Project, Tokyo Metropolitan Institute of medical
Science.)P-044
p40 induces degradation of BmAgo3 stalled on target RNAs
○Natsuko Izumi1, Keisuke Shoji1,2,3, Lumi Negish4, and Yukihide Tomari1,2(1Laboratory of RNA Function, Institute for Quantitative Biosciences, The
University of Tokyo, 2Department of Computational Biology and Medical
Sciences, Graduate School of Frontier Sciences, The University of Tokyo,
3

Graduate school of Bio-Applications and Systems Engineering, Tokyo Universityof Agriculture and Technology, 4Laboratory of Chromatin Structure and Function,
Institute for Quantitative Biosciences, The University of Tokyo)- 12 -

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P-045
Atomic structures of human mitochondrial tRNAs toward understanding
molecular pathogenesis of mitochondrial diseases○Sena Niwa1, Asuteka Nagao1, Naho Akiyama1, Nono Tomita3, Mikako
Shirouzu2, Kensuke Ishiguro1,2 and Tsutomu Suzuki1(1 Department of Chemistry and Biotechnology, Graduate School of Engineering,
The University of Tokyo, 2 Laboratory for Protein Functional and Structural
Biology, RIKEN Center for Biosystem Dynamics Research, 3 Department ofComputational Biology and Medical Sciences, Graduate School of Frontier
Sciences, The University of Tokyo)

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P-046
Selection of novel fluorogenic RNA aptamers by affinity and fluorogenicbased method and their characterization○Tomotaka Tayama1, Keisuke Ito1, Sotaro Uemura1, and Ryo Iizuka1(1Dept. Biol. Sci., Grad. Sch. Sci., The Univ. Tokyo)

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P-047
Biochemical methods for transcriptome-wide exploration of RNAs withadenosine cap structure○Noriko Miyahira1, Takayuki Ohira1, and Tsutomu Suzuki1(1 Graduate School of Engineering, The University of Tokyo)

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P-048
Exploring architectural RNAs associated to cellular senescence○Saki Fujiwara1, Naoko Fujiwara1, Takeshi Chujo2, Chao Zeng3, Michiaki
Hamada3, and Tetsuro Hirose1,4(1 Graduate School of Frontier Biosciences, Osaka University, 2 Graduate schoolof Medical Sciences, Kumamoto University, 3 Research Institute for Science andEngineering, Waseda University, 4 OTRI, Osaka University)- 13 -

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P-049
Drosophila ovarian somatic cell-specific isoform production triggered bytransposon insertion○Mai Moritoh1, Toru Morita2, Chikara Takeuchi3, Yuka W. Iwasaki3 and Mikiko C.
Siomi1(1 Graduate School of Sciences, The University of Tokyo, 2 School of Medicine,
Yokohama City University, 3 Laboratory for Functional Non-coding Genomics,
RIKEN Center for Integrative Medical Sciences)

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P-050
The molecular and physiological roles of Cnot4 in zebrafish○Koya Kageyama, Chihiro Hayashida, Yuichiro Mishima(Faculty of Lifesciences, Kyoto Sangyo University)
P-051
New solution for long RNA synthesis: A combination of chemical synthesis
and enzymatic ligation accelerates high quality manufacturing of longRNA
○Masato Sanosaka1, Natsumi Sakamoto1, Harei Sakusai1, Emi Saito1, andHirokazu Nankai1(1 Ajinomoto Bio-Pharma Services, GeneDesign, Inc)
P-052
Regulated IRE1-dependent mRNA decay is induced by physiological ER
stress in Aspergillus oryzae○Mizuki Tanaka1, Silai Zhang2, Shun Sato2, Jun-ichi Yokota2, Yuko Sygiyama2,
Yasuaki Kawarasaki3, Youhei Yamagata1, Katsuya Gomi2, Takahiro Shintani2(1 Tokyo University of Agriculture and Technology, 2 Tohoku University, 3
University of Shizuoka)- 14 -

P-053Comprehensive Database for RNA-Targeting Drug Discovery○Chao Zeng1, Michiaki Hamada1,2,3(1 Faculty of Science and Engineering, Waseda University, 2 CBBD-OIL, National
Institute of Advanced Industrial Science and Technology, 3 Graduate School of
Medicine, Nippon Medical School)㊫

P-054
Structural basis for pegRNA-guided reverse transcription by prime editor○Yutaro Shuto1, Ryoya Nakagwa1, Shiyou Zhu2,3,4,5,6, Hoki Mizuki1, Satoshi N.
Omura1, Hisato Hirano1, Yuzuru Itoh1, Feng Zhang2,3,4,5,6 & Osamu Nureki1(1 Dep. of Biol. Sci, Grad. Sch. of Sci. Univ. of Tokyo, 2 Broad Inst. of MIT andHarvard, 3 McGovern Inst. for Brain Res at MIT, 4 Dep. of Biol. Eng., MIT, 5 Dep.
of Brain and Cognitive Sci., MIT, 6 Howard Hughes Med. Inst.)
P-055
Elucidation of roles for RNA metabolic regulation in wound-induced cell
dedifferentiation
Emy Saetre1,2,*, Ola Rosengren1,2,*, Akira Iwase3, and ○Misato Ohtani1,3,4(1 Graduate School of Science, The University of Tokyo, 2 Chalmers University ofTechnology, 3 RIKEN, CSRS, 4 Division of Biological Science, NAIST)
P-056
Role of the loop region aligned with RNA-binding motifs in target
specificity of bacterial Cold-shock protein
Satoshi Hasegawa1,2, Rerina Inose1, Mizuki Igarashi1,3, Megumi Tsurumaki1,
Motofumi Saito1, Tatsuo Yanagisawa4, Akio Kanai1,2,3 and ○Teppe Morita1,3(1Inst. Adv. Biosci., Keio Univ., 2Environment & Info. Studies, Keio Univ., 3Grad.
Sch. Media & Governance, Keio Univ., 4BDR, RIKEN)- 15 -

P-057
Roles of N6-methyladenosine readers and writers in the development ofMarchantia polymorpha○Chihiro Furumizu1, Hiroko Kajiyama2, Shinichiro Sawa3(1 Graduate School of Integrated Sciences for Life, Hiroshima University, 2
School of Engineering, Hiroshima University, 3 International Research Center for
Agricultural and Environmental Biology, Kumamoto University)
P-058
Mapping the functional element of the sex-determining RNA in thecrustacean Daphnia magna using DMS-MaPseq and mutational analysis○Nikko Adhitama1,2, Christelle Alexa Garcia Perez1, Yasuhiko Kato1,2, Hajime
Watanabe1,2(1Graduate School of Engineering, Osaka University, 2Institute for Open andTransdisciplinary Research Initiatives (OTRI), Osaka University)㊫

P-059
pre-mRNA splicing links photosynthesis activity to lateral root
morphogenesis in plants○Natsu Takayanagi1, Toshihiro Arae1, Takayuki Shimizu2, Mitsuhiro Aida3,
Hidehiro Fukaki4, Tatsuru Masuda5, Misato Ohtani1,6,7(1Graduate School of Frontier Sciences, The University of Tokyo,

2

Faculty of

Science and Graduate School of Science, Nara Womenʼs University, 3 FAST,
Kumamoto University, 4 Graduate School of Science, Kobe University,5 Graduate
School of Art and Sciences, The University of Tokyo, 6 Division of Biological
Science, NAIST, 7CSRS, RIKEN)- 16 -

P-060Candidate Identification of Mobile RNAs and Their Related Genes in Pollen○Kazuki Motomura1,2, Ayumi Matsumoto1, Shigeo S. Sugano3, Ayumi Saito1,
Marin Komojiri4, Mayuko Sato5, Mayumi Wakazaki5, Daichi Susaki6, SooJung
Yang1, Yuriko Kibayashi1, Tetsu Kinoshita6, Kiminori Toyooka5, Tetsuya
Higashiyama7, Daisuke Maruyama6, and Atsushi Takeda8(1 Research Organization of Science and Technology, Ritsumeikan University, 2
PRESTO, JST, 3 Bioproduction Research Institute, AIST, 4 Center for EcologicalResearch, Kyoto University, 5 Center for Sustainable Resource Science, RIKEN, 6
Kihara Institute for Biological Research, Yokohama City University, 7 Departmentof Biological Sciences, Graduate School of Science, The University of Tokyo, 8College of Life Sciences, Ritsumeikan University)㊫

P-061
Detection and quantification of multiple tRNA modification status bynanopore sequencing○Yosei Hanzawa1, Ryo Noguchi1, Takayuki Ohira1, and Tsutomu Suzuki1(1 Department of Chemistry and Biotechnology, Graduate School of Engineering,
The University of Tokyo)

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P-062
PNUTs, a transcription terminator, represses transposable elements in the
Piwi-piRNA pathway○Yaning Wu, Rin Imai, Haruhiko Siomi, Kensaku Murano(Department of Molecular Biology, Keio University School of Medicine)

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P-063
Effect of the conformational equilibrium in the microRNA precursor premiR-21 on the activity of a maturation-inhibitor L50○Yuhei Nishimura1, Yuji Tokunaga1, and Koh Takeuchi1(1 Graduate School of Pharmaceutical Sciences, The University of Tokyo)- 17 -

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P-064
The third biosynthesis pathway of 4-thiouridine in tRNA
Yuzuru Sugio1, ○Sota Yamasaki1, Junya Ueda1, Ryo Isogai1, Natsumi
Matsumoto1, Minoru Hayashi1, Ryota Yamagami1, Akira Hirata2, Chie Tomikawa1,
Satoshi Ohno3, Takuya Kawamura1, Takashi Yokogawa3, and Hiroyuki Hori1(1Graduate School of Science and Engineering, Ehime University, 2Graduate
School of Technology, Industrial and Social Science, Tokushima University,
3

Faculty of Engineering, Gifu University)

P-065
Sulfolobales TmcA1 and TmcA2 are ac4C writers that acetylate distinct
RNA substrates and differently contribute to thermal adaptation○Takayuki Ohira1, Masaki Takegawa1, Kensuke Ishiguro1, Ryo Matsuda2, Norio
Kurosawa2, and Tsutomu Suzuki1(1 Graduate School of Engineering, The University of Tokyo, 2 Graduate school of
Science and Engineering, Soka University)㊫

P-066
Spatiotemporal regulation of methanol-inducible mRNAs in the
methylotrophic yeast Candida boidinii○Fuka Sekioka, Kosuke Shiraishi, Miho Akagi, Akari Habata, Hiroya Yurimoto
and Yasuyoshi Sakai(1 Graduate School of Agriculture, Kyoto University)
P-067
General remarks of the promoter element 2 regulating genome replicationof paramyxoviruses and filoviruses
Shoichi Ashida1, ○Yusuke Matsumoto1(1 Transboundary Animal Diseases Research Center, Joint Faculty of Veterinary
Medicine, Kagoshima University)- 18 -

P-068Functionalization of chemically modified mRNA using engineered RNA andRNA binding protein○Tatsuyuki Yoshii1, Masumi Ohshima2, Hirohide Saito1,2(1Institute for Quantitative Biosciences, The University of Tokyo 2Center for iPS
Cell Research and Application, Kyoto University)
P-069
Structural insights into the complex of m6A methyltransferase METTL16
and U6 snRNA○JU Jue1, Kozo Tomita1(1 Department of Computational Biology and Medical Sciences, Graduate Schoolof Frontier Sciences, The University of Tokyo)㊫

P-070
Structural analysis of the 5′-UTR of OsMac3 mRNA which involved in theefficient translation○Tomoaki Kubo, Mitsuru Kubono, Gota Kawai（Graduate School of Advanced Engineering, Chiba Institute of Technology）

㊫

P-071
Roles of the deadenylase complexes, Ccr4-Not and Pan2-Pan3, in yeast
cell growth○Nozomi Endo and Kenji Irie
(Laboratory of Molecular Cell Biology, Faculty of Medicine, University of Tsukuba)
P-072
Circadian variation of miRNAs in mouse plasma○Parvez MD SORWER Alam, Eisuke Dohi
(1 National Center of Neurology and Psychiatry, National Institute of
Neuroscience, Department of Mental Disorders)- 19 -

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P-073
Development of translational enhancement technique using designer PPR(Pentatricopeptide Repeat) proteins○Zhiyan Liu1, Ning Ping1, Takahiro Nakamura1(1Faculty of Agriculture, Kyushu University.)
P-074
AtCAF1i/k, deadenylases in Arabidopsis, are important for de novo shootorganogenesis○Toshihiro Arae1, Sota Kurachi2, Kosuke Kawai2, Riko Imahori2, Yukako Chiba2,3,
Misato Ohtani1(1 Grad. Sch. Frontier Sci., Univ. Tokyo, 2 Grad. Sch. Life Sci., Hokkaido Univ., 3
Fac. Sci., Hokkaido Univ.)
P-075
mRNA-specific translational repression by hnRNPU
Kaene Sugano1, Misato Shirakawa1, ○ Shin-ichi Kashiwabara1(1Institute of Life and Environmental Sciences, University of Tsukuba)

㊫

P-076
Lysine-transfer reaction mechanism by the complex of ArcS and RaSEA
for archaeosine biosynthesis in tRNA.
○Shu Fujita1, Yuzuru Sugio1, Takuya Kawamura1, Ryota Yamagami1, Natsuhisa
Oka2, Akira Hirata3, Takashi Yokogawa2, and Hiroyuki Hori1(1 Graduate School of Science and Engineering, Ehime University, 2 Faculty ofEngineering, Gifu University, 3 Graduate School of Technology, Industrial andSocial Science, Tokushima University)- 20 -

P-077A universal tool for characterization of RNA discovered by SELEX○Shunsuke Sumi1,2, Tatsuyuki Yoshii2, Tatsuo Adachi3, Hirohide Saito2, andMichiaki Hamada1,4,5(1 Faculty of Science and Engineering, Waseda University, 2 Institute of
Quantitative Bioscience, The University of Tokyo, 3 RIBOMIC Inc., 4Computational Bio Big-data Open Innovation Laboratory (CBBD-OIL), 5 National
Institute of Advanced Industrial Science And Technology (AIST))㊫

P-078
Elucidating the role of Vasa in the accumulation of transposon transcripts
in Vasa bodies○Mizuki Fukuda1, Hiroya Yamazaki1, and Mikiko.C.Siomi1(1 Graduate School of Science, The University of Tokyo)
P-079
ANP32A is a critical host factor for Borna disease virus replication andcontributes to host tropism○Hiromichi Matsugo12, Kosuke Yusa3, Akiko Makino12, Keizo Tomonaga124(1 Laboratory of RNA Viruses, Department of Virus Research, Institute for Life
and Medical Sciences, Kyoto University

2

Department of Mammalian

Regulatory Network, Graduate School of Biostudies, Kyoto University

3

Laboratory of Stem Cell Genetics, Department of Biosystems Science, Institutefor Life and Medical Sciences, Kyoto University

4

Department of Molecular

Virology, Graduate School of Medicine, Kyoto University)
P-080
Overexpression of pigq gene restores the blood cell counts in a zebrafish
model of Diamond-Blackfan anemia○Tamayo Uechi1, Mariko Nagatomo1, Maki Yoshihama1, Yukari Nakajima1,
Yutaka Suzuki2, Naoya Kenmochi1(1Faculty of Medicine, University of Miyazaki, 2Department of Medical Genome
Science, University of Tokyo)- 21 -

㊫

P-081
Translational regulation mediated by ligand-induced tRNA activation○Ren Nakazaki1, Asuteka Nagao1, Kensuke Ishiguro1, Takeshi Yokoyama2,
Yoshikazu Tanaka2 & Tsutomu Suzuki1(1 Department of Chemistry and Biotechnology, Graduate School of Engineering,
The University of Tokyo, 2 Graduate School of Life Sciences, Tohoku University)

㊫

P-082
Sequence characterization and prediction of semi-extractable RNAs
○Ryoma Yamawaki1,Chao Zeng1,Michiaki Hamada1,2(1 Faculty of Science and Engineering, Waseda university, 2. Computational Bio
Big-data Open Innovation Laboratory (CBBD-OIL), National Institute ofAdvanced Industrial Science And Technology (AIST))
P-083
Glycosylated queuosines in tRNAs optimize translational rate and postembryonic growth○K. Ishiguro1,2, X. Zhao1, D. Ma1, H. Saito3,4, S. Akichika1, I. Matsuzawa1, M.
Mito3, T. Irie5, K. Ishibashi5, K. Wakabayashi5, Y. Sakaguchi1, T. Yokoyama2,6, Y.
Mishima5, M. Shirouzu2, S. Iwasaki3, Ta. Suzuki1, Ts. Suzuki1(1 Graduate School of Engineering, University of Tokyo, 2 Center for Biosystems
Dynamics Research, Riken, 3 Cluster for Pioneering Research, Riken, 4 Graduate
School of Frontier Sciences, University of Tokyo, 5 Faculty of Life Sciences, Kyoto
Sangyo University, 6 Graduate School of Life Sciences, Tohoku University)- 22 -

P-084
TRMT10A dysfunction perturbs codon translation of initiator methionine
and glutamine and impairs brain functions in mice
○Roland Tresky1, Yuta Miyamoto1, Yu Nagayoshi1, Yasushi Yabuki2, Kimi Araki3,
Yukie Takahashi1, Yoshihiro Komohara1, Huicong Ge1, Kayo Nishiguchi1, Takaichi
Fukuda1, Hitomi Kaneko1, Nobuko Maeda1, Jin Matsuura1, Shintaro Iwasaki4,
Kourin Sakakida1, Norifumi Shioda2, Fan-Yan Wei5, Kazuhito Tomizawa1, and○Takeshi Chujo1(1Faculty of Life Sciences, Kumamoto University, 2IMEG, Kumamoto University,
3

IRDA, Kumamoto University, 4RIKEN, 5IDAC, Tohoku University)

P-085
Deciphering the functions of the RNA helicase DDX6 in the nucleus ofhuman cells
Chia-Yu Shih1, Jui-Hsuan Liang1, Jo-Hsi Huang1, Yun-Chi Chen1, Heng-Yi Lin1,
and ○Chia-Ying Chu1,2(1 Department of Life Science, 2 Center for Computational and Systems Biology,
National Taiwan University, Taiwan.)
P-086
RNaseX25-mediated RNA degradation during early embryonicdevelopment○Shiho Makino1, Yoshinori Ohsumi2, Takashi Fukaya1(1Institute for Quantitative Biosciences, The University of Tokyo, 2 Cell Biology
Center, Institute of Innovative Research, Tokyo Institute of Technology)㊫

P-087
Structure analysis of small non-coding RNAs, CeR-2a and CeR-2b,
involved in rRNA processing in C. elegans○Hayato Sugawara1, Miu Tsumagari1, Yudai Usami1, Chisato Ushida2 and Gota
Kawai1(1Graduate School of Advanced Engineering, Chiba Institute of Technology,
2

Faculty of Agriculture and Life Science, Hirosaki University)- 23 -

P-088
SRP9 migrates nucleus and regulates gene expression through binding tovarious non-coding RNAs
○Tomoaki Hara1, Sikun Meng1, Hiromichi Sato1,2, Kazuki Sasaki1,2, Yasuko
Arao1, Yoshiko Saito1, Ken Ofusa1,3, Daisuke Motooka4, Yuichiro Doki2, Hidetoshi
Eguchi2 and Hideshi Ishii1(1.Department of Medical Data Science, Center of Medical Innovation andTranslational Research, Osaka University Graduate School of Medicine,2.Department of Gastroenterological Surgery, Osaka University Graduate Schoolof Medicine, 3.Prophoenix Division, Food and Life-Science Laboratory, IDEA
Consultants, Inc., 4.Genome Information Research Center, Research Institute forMicrobial Diseases, Osaka University)㊫

P-089
Generation of a conditional Xist knockdown mouse model using Cas7-11○Nao Watanabe1, Maho Hashimoto1, Tomoki Chiba1, Hiroshi Asahara1(1 Department of Systems BioMedicine, Tokyo Medical and Dental University(TMDU))P-090
HSATIII-derived proteins are novel components of a protein complex
potentially associated with actin cytoskeleton dynamics○Kensuke Ninomiya1, Shungo Adachi2, Tetsuro Hirose1, 3(1 Graduate School of Frontier Biosciences, Osaka University, 2National Cancer
Center Research Institute, 3OTRI, Osaka University)- 24 -

㊫

P-091
Mechanisms of mRNA-independent translation reaction in mammaliancells○Shuhei Ebine1, Takuya Tomita2, Petr Tesina3, Robert Buschauer3, Matthias
Thoms3, Yoshitaka Matsuo1, Roland Beckmann3, Yasushi Saeki2, Toshifumi
Inada1(1. Division of RNA and Gene Regulation, IMSUT, The University of Tokyo, 2.
Division of Protein Metabolism, IMSUT, The University of Tokyo, 3. Gene Center,
LMU Munich)

㊫

P-092
Analysis of changes in the structure and function of germ granules by
Nanos during Drosophila embryogenesis○Yasuhiro Kozono1, Miho Asaoka2, Makoto Hayashi3 and Satoru Kobayashi2(1 Deg. Prog. in Life and Earth Sci., Grad. Sch. of Sci. and Tech., University ofTsukuba, 2 Life Science Center for Survival Dynamics, University of Tsukuba, 3Institute for Reproductive Biotechnology for Aquatic Species (IRBAS), Tokyo
University of Marine Science and Technology)
P-093
Structural basis for the interaction between the UUCG stem-loop ofhuman U1 snRNA and the ubiquitin like domain of the SF3A1 subunit inU2 snRNP○Kanako Kuwasako1, Shin-ichi Terawaki2, Masayuki Takizawa1, Madoka
Kitamura1, Yutaka Muto1 and Nobukazu Nameki3(1 Faculty of Pharmacy and Research Institute of Pharmaceutical Sciences,
Musashino University, 2 Proteo-Science Center, Ehime University, 3 Graduate
School of Science and Technology, Gunma University)- 25 -

㊫

P-094
TRBP regulates RLR-mediated antiviral innate immune signal○Monami Sakai1, Koji Onomoto1, Miyu Watanabe1, Tomoko Takahashi2,3,
Kumiko Ui-Tei3,4, Mitsutoshi Yoneyama1,5(1 Medical Mycology Research Center, Chiba University, 2Graduate School of
Science and engineering, Saitama University, 3Graduate School of Science, The
University of Tokyo, 4Graduate School of Frontier Sciences, The University ofTokyo,5Research Institute of Disaster Medicine, Chiba University)
P-095
ER protein Kinectin 1 regulates cellular localization of multi-tRNA
synthetase complex in a variant-specific manner○Masaki Hosogane1, Sue Yi Siao2, Atsushi Hatano3, Masaki Matsumoto3 andKeiko Nakayama1(1 Division of Cell Proliferation, Graduate School of Medicine, Tohoku University, 2
Graduate School of Life Sciences, Tohoku University, 3 Department of Omics andSystems Biology, Niigata University)
P-096
Possible regulation of piRNA target transposons via DNA methylationindependent mechanism○Hiromi Yamada1, Chikara Takeuchi1,2, and Yuka W. Iwasaki1(1Laboratory for functional non-coding genomics, Center for Integrative Medical
Science, RIKEN, 2Green Center for Reproductive Biology Sciences, University ofTexas Southwestern Medical Center)

㊫

P-097
A novel Drosha isoform specifically expressed in embryonic stem cells andgerm line cells in mice
○Yuji Shimizu1, Ren Shimamoto1, Ayako Isotani1, and Katsutomo Okamura1(1 Division of Biological Science, Nara Institute of Science and Technology)- 26 -

㊫

P-098
Single molecule detection of tRNA modifications by signal alignment of
nanopore sequencing data
○Ryo Noguchi1, Mai Maeda1, Qiuyu Wang1, Bhaskar Dasgupta2, Hiroki Ueda2,
Tsutomu Suzuki1(1 Department of Chemistry and Biotechnology, School of Engineering, The
University of Tokyo, 2 Research Center for Advanced Science and Technology,
The University of Tokyo)

㊫

P-099
Analysis of the interaction between m6Am methyltransferase
PCIF1/CAPAM and translational repressor PAIP2○Chihiro Oyama1, Ryoya Kano1, Shiori Toyama1, Haruki Ikezawa1, Chihiro
Ikeda1, Shiho Ito1, Ai Sugita1, Aki Tanaka1, Yoshiaki Ohkuma2, Shinichiro
Akichika3, Tsutomu Suzuki3, Yutaka Hirose1(1 Grad. Sch. of Med. & Pharma. Sci., Univ. of Toyama, 2 Grad. Sch. of Biomed.
Sci., Nagasaki Univ., 3 Grad. Sch. of Eng., Univ. of Tokyo)

㊫

P-100
Structural Analysis of stem-loop RNAs involved in the regulation of
immunity and their interaction with Regnase-1○Shiho Nakao1, Yuna Shimizu2, Hinano Kobayashi1, Gota Kawai1,2(1Graduate School of Advanced Engineering, 2Faculty of Advanced Engineering,
Chiba Institute of Technology)
P-101
Application of the B. subtilis ultra-transformation system to tRNA study.
○Akiko Soma1, Ritsuho Yamakawa1, Fujio Kawamura1, Tsukasa Kouchi1, Genki
Akanuma2, Yuma Okubo1(1Graduate School of Horticulture, University of Chiba, 2 Department ofChemistry, Josai University)- 27 -

㊫

P-102
Cap specific m6A methyltransferase PCIF1/CAPAM modulates type I IFN
responses○Ryoya Kano1, Chihiro Oyama1, Chihiro Ikeda1, Ai Sugita1, Hiroyasu Ishiguro1,
Aki Tanaka1, Akiko Inujima2, Keiichi Koizumi3, Shinichiro Akichika4, Tsutomu
Suzuki4, Yoshiaki Tabuchi5, Yoshiaki Ohkuma6, Yutaka Hirose1(1 Grad. Sch. of Med. & Pharm. Sci., Univ. of Toyama, 2Div. of Med. Oncology,
Cancer Res. Inst., Kanazawa Med. Univ., 3 Div. of Presymptomatic Disease, Inst.
of Natural Med., Univ. of Toyama, 4 Grad. Sch. of Eng., Univ. of Tokyo, 5 Life Sci.
Res. Center, Univ. of Toyama, 6 Grad. Sch. of Biomed. Sci., Nagasaki Univ.)

㊫

P-103
Single molecule detection of human mitochondrial tRNA modification bynanopore sequencing○Qiuyu Wang1, Ryo Noguchi1, Ena Tomoda1, Tsutomu Suzuki1(1 Dept. of ChemBio., Sch. of Eng., Univ. of Tokyo)

㊫

P-104
The MTR4/hnRNPK complex-mediated degradation of aberrant
polyadenylated RNAs with multiple exons○Xinyue Gao1,2, Kenzui Taniue1, Anzu Sugawara1, Chao Zeng3, Han Han1,2,Masahide Seki4, Yutaka Suzuki4, Michiaki Hamada3,5, Nobuyoshi Akimitsu1,2(1 Isotope Science Center, The University of Tokyo, 2 Graduate School of
Pharmaceutical Sciences, The University of Tokyo, 3 Faculty of Science andEngineering, Waseda University, 4 Graduate School of Frontier Sciences, The
University of Tokyo, 5 AIST-Waseda University Computational Bio Big-Data Open
Innovation Laboratory, National Institute of Advanced Industrial Science andTechnology)- 28 -

㊫

P-105
Exploring the landscape of tRNA modifications in ageing○Longteng Zhang1, Raja Norazireen Raja Ahmad1, Lin Liu1, Yue Xu1, Shigeru
Matsuda1, Haruna Tani1, Akiko Ogawa1, Fan-Yan Wei1
(1 Department of Modomics Biology and Medicine, Institute of Development
Aging and Cancer, Tohoku University)
P-106
Insights into the role of eukaryotic translation initiation factor 3 (eIF3) on
Hepatitis C virus IRES-mediated translation○Wakana Iwasaki1, Kazuhiro Kashiwagi1, Ayako Sakamoto1, Madoka Nishimoto1,
Mari Takahashi1, Kodai Machida2, Hiroaki Imataka2, Koshi Imami3, Akinobu
Matsumoto4, Yuichi Shichino5, Shintaro Iwasaki5,6, and Takuhiro Ito1
(1 Laboratory for Translation Structural Biology, RIKEN Center for Biosystems
Dynamics Research, 2 Graduate School of Engineering, University of Hyogo, 3
Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical
Sciences, 4 Group of Gene Expression and Regulation, Nagoya University, 5 RNA
Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, 6
Graduate School of Frontier Sciences, The University of Tokyo)
P-107
Oligonucleotide Chemical Ligation Reactions Aimed at Long RNA
Production○Harei Sakurai1, Yu Hirano2, Naoshi Kojima2, Masato Sanosaka1, Emi Saito1,
Hirokazu Nankai1 and Yasuo Komatsu2(1 Ajinomoto Bio-Pharma Services, GeneDesign, Inc., 2 National Institute ofAdvanced Industrial Science and Technology)

P-108
Translation-dependent Degradation of Small Ribosomal Subunits○Sihan Li1, Okuto Shounai2, Toshifumi Inada1(1 The Institute of Medical Science, The University of Tokyo, 2 Graduate Schoolof Pharmaceutical Sciences, Tohoku University)- 29 -

㊫

P-109
Structural polymorphism of the nucleic acids in pentanucleotide repeats
associated with the neurological disorder CANVAS○Kenta Kudo, Karin Hori, Norifumi Shioda(Department of Genomic Neurology, Institute of Molecular Embryology andGenetics (IMEG), Kumamoto University)

㊫

P-110
Identification of mouse cardiac-specific Ttn splicing isoforms targetd bywild-type and mutant Rbm20 using Long-read sequencing○Yuri Yamasu1,2, Marina Ohno-Togo1, Eichi Watabe1, Hidehito Kuroyanagi2(1 Tokyo Medical and Dental University, 2 University of the Ryukyus)
P-111
tRNA modifications orchestrate the translational response tomitochondrial stress.
○Sherif Rashad, MD. Shadi Al-Mesitef. Abdulrahman Mousa. Kuniyasu Niizuma,
MD, PhD.
(Department of Neurosurgical Engineering and Translational Neuroscience,
Graduate School of Biomedical Engineering, Tohoku University, Sendai, Japan.)

㊫

P-112
CUG repeat RNA promotes proteasomal degradation of MBNL1○ Yoshitaka Aoki1, Ai Ohki1, Motoaki Yanaizu1, Yoshihiro Kino1(1 Department of RNA Pathobiology and Therapeutics, Meiji Pharmaceutical
University)

㊫

P-113
Translational regulation of haploid-specific mRNAs during
spermatogenesis○Yuka Isono, Hideto Tanaka, Shin-ichi Kashiwabara(Institute of Life and Environmental Sciences, University of Tsukuba)- 30 -

P-114
The 3ʼ additional and promoter sequences of Borna disease virus 1
genome coordinately regulate viral transcription and replication.
○Takehiro Kanda1,2, Keizo Tomonag1,2,3(1 Institute for Life and Medical Sciences, Kyoto University, 2 Graduate School of
Medicine, Kyoto University, 3 Graduate School of Biostudy, Kyoto University)㊫

P-115
Self-alkylating ribozymes available with N1 methyl pseudouridine RNA○Yuki Hada1, Tatsuyuki Yoshii2, Hirohide Saito2,3(1 Graduate School of Engineering, The University of Tokyo, 2 Institute forQuantitative Biosciences, The University of Tokyo, 3 Center for iPS Cell Researchand Application, Kyoto University)

㊫

P-116
SSA Stabilizes c-Myc mRNA
○Fuku Matsuda1, Midori Shima1, Mayuko Hotta1, Daisuke Kaida1(1 School of Medicine, The University of Toyama)

㊫

P-117
Mechanistic insights into the roles of the UFM1 E3 ligase complex inufmylation and ribosome-associated protein quality control○Sota Ito1, Ryosuke Ishimura2, Gaoxin Mao2, Satoko Komatsu-Hirota2, Nobuo N
Noda3, Masaaki Komatsu2 and Toshifumi Inada1(1The Institute of Medical Science, The University of Tokyo, IMSUT, 2Departmentof Physiology Juntendo University,Graduate School of Medicine, 3Institute for
Genetic Medicine Hokkaido University)- 31 -

㊫

P-118
Elucidation of the molecular mechanism for ribosomal protein eS7A
ubiquitination that contributes to Unfolded Protein Response○Nichika Sato1,2, Yasuko Matsuki3, Yu Nakano3, Yoshitaka Matsuo2, Toru
Yoshihisa4 and Toshifumi Inada1,2(1 Graduate School of Science, The University of Tokyo, 2 The Institute ofMedical Science, The University of Tokyo, 3 Graduate School of Pharmaceutical
Sciences, Tohoku University, 4 Graduate School of Science, University of Hyogo)
P-119
Nanopore direct RNA sequencing reveals the METTL2A-mediated 3methylcytidine sites on poly(A) RNAs
○Shuhei Mitsutomi 1,2, Kenzui Taniue 2,3, Anzu Sugawara 2, Nobuyoshi Akimitsu
2(1 Research Institute, National Cancer Center, 2 Isotope Science Center, The
University of Tokyo, 3 Department of Medicine, Asahikawa Medical University)㊫

P-120
RNA G-quadruplexes facilitates Tau phase transition in vitro.
○Ginji Komiya1,2、Norifumi Shioda1,2、Yasushi Yabuki1,2(1 Department of Genomic Neurology, Institute of Molecular Embryology andGenetics, The University of Kumamoto、2 School of Pharmacy, The University of
Kumamoto)
P-121
Enhancing Purification of Messenger RNA Drug Substances: Exploring
Macroporous Resin Particles for Improved Separation from
Immunostimulatory dsRNA Impurities○Yuki Higuchi1, Saoko Nozawa1, Akinari Awatani1, 2, Takashi Sekida2, Taeko
Nakajima1(1 YMC CO., LTD., 2 VLP Therapeutics Japan Inc.)- 32 -

P-122
Molecular basis for activation of plant organellar C-to-U RNA editosome
Tenghua Wang1, ○Mizuki Takenaka1(1 Graduate School of Science, Kyoto University)
P-123
RNA binding protein RBPU maintains cancer stem like status in triple
negative breast cancer○Yutaro Uchida1, Ryota Kurimoto1, Tomoki Chiba1, Takahide Matsushima1,
Yasuto Takeuchi2, Noriko Gotoh2, Hiroshi Asahara1, 3(1 Department of Systems Biomedicine, Tokyo Medical and Dental University,
P-124
Demystifying the m6A epitranscriptome: a novel deep neural networkbased method for long-read sequencing data
○Boyi Yu1, Genta Nagae2, Yutaka Midorikawa3, Kenji Tatsuno2, Bhaskar
Dasgupta1, Satoshi Ota2, Hiroyuki Aburatani2, Hiroki Ueda1(1 Advanced Data Science Division, Research Center of Advanced Science andTechnology, The University of Tokyo, 2 Genome Science & Medicine Division,
Research Center of Advanced Science and Technology, The University of Tokyo, 3
Department of Digestive Surgery, Nihon University School of Medicine)

㊫

P-125
A subset of primordial germ cells exhibit impaired function of piRNA
machinery in Drosophila embryos.
○Kyohei Mikami1,2, Masaki Masukawa1,2 and Satoru Kobayashi1,2.
(1 Degree Program in Life and Earth Sciences, Graduate School of Science andTechnology, University of Tsukuba, 2 Life Science Center for Survival Dynamics,
University of Tsukuba.)- 33 -

P-126mRNA therapeutics development strategy with optimized mRNA designfor effective target protein expression○Akiko Yanagiya1, Rena Akahori1, Hiroaki Murakami1, Azusa Tanaka1, Yanwen
Feng1, Hayato Sato1, Naoki Matsumoto1, Daichi Matsuura1, Jun Nihira1, Tetsuo
Yoshida2, Yuki Hasegawa2, Kazuyuki Nakashima1(1 CMC Development, 2 Business Development, ARCALIS, Inc.)㊫

P-127
Circular RNA synthesis from circular DNA template○Yui Yoneda1, Masayuki Suetsugu1(1Graduate School of Life Science, Rikkyo University)
P-128
Identifying and characterizing host cellular proteins binding to the nonpolyadenylated 3′-untranslated region of LCMV mRNA
○Mei Hashizume1, Ayako Takashima1, Keiko Shindo1, Masaharu Iwasaki1,2,3,4(1 Laboratory of Emerging Viral Diseases, International Research Center for
Infectious Diseases, Research Institute for Microbial Diseases, Osaka University,
2

Center for Infectious Disease Education and Research, Osaka University, 3 RNA

Frontier Science Division, Institute for Open and Transdisciplinary Research
Initiatives, Osaka University, 4 Center for Advanced Modalities and Drug Delivery
System, Osaka University)- 34 -

㊫

P-129
Phosphorylation of human TNRC6A modulates Argonaute binding
responsible for RNA silencing activity○Li Shen,3 Masataka Suzawa,1 Hiroko Kozuka-Hata,2 Masaaki Oyama,2 Kumiko
Ui-Tei1,3,*(1Department of Biological Sciences, Graduate School of Science, University ofTokyo, Tokyo 113-0033, Japan, 2Medical Proteomics Laboratory, Institute ofMedical Science, The Universityof Tokyo, Minato-ku, Tokyo, Japan, 3Department of Computational Biology andMedical Sciences, Graduate School of Frontier Sciences, University of Tokyo,
Chiba-ken 277-8651, Japan)
P-130
Ongoing Participation Report on RNA 3D structure prediction at CASP16:
Usage and limitations of AlphaFold3○Junichi Iwakiri1, Takumi Otagaki1, Kazuteru Yamamura1, Shunsuke Sumi2,3,
Jiro Kondo4 and Kengo Sato5(1 Graduate School of Frontier Sciences, The University of Tokyo, 2 Institute forQuantitative Biosciences (IQB), The University of Tokyo, 3 Graduate School of
Advanced Science and Engineering, Waseda University, 4 Department ofMaterials and Life Sciences, Sophia University, 5 School of System Design andTechnology, Tokyo Denki University)

㊫

P-131
A random walk approach to cluster and integrate spatial transcriptomics
data○Reiichi Sugihara1, Yuki Kato1,2 and Yukio Kawahara1,2(1 Graduate School of Medicine, Osaka University, 2 Institute for Open andTransdisciplinary Research Initiatives, Osaka University)- 35 -

㊫

P-132
Organ-specific gene expression control using DNA origami-based
nanodevices○Yuxiang Liu1,6, Ruixuan Wang1,6, Qimingxing Chen1, Yan Chang1, Qi Chen1,
Kodai Fukumoto2,3, Bingxun Wang1, Jianchen Yu1, Changfeng Luo1, Jiayuan Ma1,
Xiaoxia Chen1, Yuko Murayama3, Kenichi Umeda4, Noriyuki Kodera4, Yoshie
Harada2, Shun-ichi Sekine3, Jianfeng Li1,5 * and Hisashi Tadakuma1,5 *(1 School of Life Science and Technology, ShanghaiTech University, 2 Institute forProtein Research, Osaka University, 3 RIKEN Center for Biosystems Dynamics
Research, 4 Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, 5Gene Editing Center, School of Life Science and Technology, ShanghaiTech
University, 6 These authors contributed equally)

㊫

P-133
Structural analysis of a stem-loop in the intergenic region of Plautia stali
intestine virus genome RNA○Kousei Sakaguchi1, Ryo Okubo2, and Gota Kawai1,2(1Graduate School of Advanced Engineering, 2Faculty of Advanced Engineering,
Chiba Institute of Technology)
P-134
Development of a Method for Simultaneous Detection of Multiple RNA
Modifications Using Nanopore Sequencing○Hiroki Ueda1, Bo-yi Yu 1, Keisuke Yamada2, Akihide Yoshimi3, Genta Nagae2,
Hiroyuki Aburatani, 2(1 Advanced Data Science, RCAST, The University of Tokyo, 2 Genome Science &Medicine, RCAST, The University of Tokyo, 3Division of Cancer RNA Research,
National Cancer Center Research Institute)- 36 -