ඛ➃໬Ꮫ⏕࿨ᕤᏛ◊✲ D&<%(5 ࢭࣥࢱ࣮άືሗ࿌                aCYBER ࢭࣥࢱ࣮㛗 ⓑ▼ ᾈᖹ      ᡤဨ ᒣ⏣ ᗣᯞ㸪Ώ㑓 ⩏அ㸪ᑠᕝ ᬛᘯ㸪໭ᒸ ㈼㸬ᖹᡂ  ᖺᗘάືሗ࿌ࣄࢺ⣽⬊ᰴࡢ฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲ ⓑ▼㸪ᒣ⏣ 㸺┠ⓗ㸼⣽⬊᥋╔ࢆไᚚࡍࡿ㧗ศᏊ⏕యᮦᩱ࠶ࡿ࠸ࡣᇶᯈ࡜ࡑࢀࡽ࡜ࣟ࣎ࢸ࢕ࢡࢫࢆ⼥ྜࡋࡓ㑇ఏᏊ㸪ࢱࣥࣃࢡ㉁ࡢ⥙⨶ⓗゎᯒ࠶ࡿ࠸ࡣ⣽⬊᧯స㸦ᅇ཰࣭⼥ྜ㸧ࢩࢫࢸ࣒ࡢᵓ⠏ ⓑ▼㸪ᒣ⏣ ⌧≧࡜⤖ᯝ ⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖ࡢ◊✲࡟࠾࠸࡚㸪⣽⬊ࢆ⏝࠸ࡓࣁ࢖ࢫ࣮ࣝࣉࢵࢺ࡞ᶵ⬟ゎᯒࡢࡓࡵࡢᇶᮦ㛤Ⓨ㸪ୗ㝈⮫⏺ඹ⁐ ᗘᆺ㸪ୖ㝈⮫⏺ඹ⁐ ᗘᆺ ᗘᛂ⟅ᛶ࣏࣐࣮ࣜࡢ㛤Ⓨ㸪㔠ࢫ࣏ࢵࢺ࡬ࡢ㑅ᢥⓗ࡞⣽⬊ࡢ᥋╔ࡀྍ⬟࡞⣽⬊࢔ࣞ࢖ࡢㄪ〇㸪⣽⬊᥋╔㡿ᇦ㸪㠀᥋╔㡿ᇦࡢᵓ⠏㸪⣽⬊᥋╔ᚋࡢ⣽⬊ᶵ⬟ࡢ᳨ウ㸪ࣄࢺேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ࢆᑟධࡍࡿ⣽⬊⼥ྜ⏝ᇶᯈ࡜ࣃࣝࢫ࣮ࣞࢨ࣮ග⣽⬊⼥ྜ㸪CW ࣮ࣞࢨ࣮ගࣆࣥࢭࢵࢺ㸪CW ࣮ࣞࢨ࣮ගຍ ࡞࡝ࡍ࡭࡚㸪㡰ㄪ࡟㐍ࢇ࡛࠸ࡿ㸬ࡉࡽ࡟㸪࣮ࣞࢨ࣮࡟ࡼࡾ୙⏝࡞⣽⬊ࢆ㝖ࡃ࠶ࡿ࠸ࡣ᭷⏝⣽⬊ࡢࡳࢆ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰ࡍࡿࢩࢫࢸ࣒࠾ࡼࡧ⿦⨨ࢆ㛤Ⓨࡋ࡚࠸ࡿ㸬⣽⬊⼥ྜࡢᶵ⬟ࢆά⏝ࡋ࡚㸪㑇ఏᏊ㸪ࢱࣥࣃࢡ㉁➼ࡢ⣽⬊ෆᑟධᐇ㦂࡬ࡢᒎ㛤ࡉࡽ࡟ࡣ㸪ࣂ࢖࢜◊✲⪅ࡽ࠿ࡽࡢㄪᰝ࠿ࡽ㸪ᑡᩘ⣽⬊ࡢ㠀౵くᛶᅇ཰ࡀ᭷⏝࡛࠶ࡿࡇ࡜࠿ࡽ㸪 ᗘᛂ⟅ᛶ⣽⬊࢔ࣞ࢖ࡢᨵၿࢆ㐍ࡵ࡚࠸ࡿ㸬ࡲࡓ㸪⣽⬊デ᩿᫬࡟ಶ⣽⬊ࡼࡾࡶ⮚ჾ➼ࡢᛂ⟅࡟㏆ࡃ⢭ᐦ࡞⸆๣࡞࡝ࡢᛂ⟅ࡀᮇᚅࡉࢀࡿ⣽⬊ࢫࣇ࢙ࣟ࢖ࢻࡢㄪ〇ࡍࡿࡓࡵ㸪⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖ࢆ⏝࠸࡚╔ᡭࡋࡓ㸬 ◊✲ィ⏬ ⣽⬊࢔ࣞ࢖ࢆ⏝࠸࡚᭷⏝⣽⬊࡜デ᩿ࡉࢀࡓ࢔ࣞ࢖ࢫ࣏ࢵࢺୖ࡟࣮ࣞࢨ࣮ග࡛ຍࡋ࡚⣽⬊ࢆ㑅ᢥⓗ࠿ࡘ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰࡟ࢩࢫࢸ࣒㐍໬ࡉࡏ㸪ࡉࡽ࡟ຠ⋡ࡼࡃ⣽⬊᳨ฟ࣭ศูࡀฟ᮶ࡿ᮲௳ࢆ᳨ウࡋ࡚࠸ࡿ㸬⾲㠃࡟ฎ⌮ࡍࡿᶵ⬟ᛶ⣲ᮦࢆᗮ౯࡛ࡇࢀࡲ࡛ࡢྠࡌ࠶ࡿ࠸ࡣࡑࢀ௨ୖࡢᶵ⬟ࢆ㐩ᡂࡍࡿࡓࡵ࡟⣲ᮦࡢ᭱㐺໬ࢆ㐍ࡵ࡚࠸ࡿ㸬⣽⬊㠀᥋╔ᒙࢆ⡆౽࡞⁐፹ࢥ࣮ࢸ࢕ࣥࢢ࡛ᐇ᪋ࡍࡿᡭἲ࡟ኚ᭦ࡢୖ㸪᪤Ꮡ࡟࣮ࣞࢨ࣮⿦⨨ࢆ౑ࡗ࡚⣽⬊ࢫ࣏ࢵࢺࡢຍᕤࡶᐇ᪋ࡋ࡚࠸ࡿ㸬ࢫࣇ࢙ࣟ࢖ࢻᙧᡂ࢜ࢡࢱ࣌ࣉࢳࢻࡢ⣽⬊࢔ࣞ࢖࡬ࡢᅛᐃ໬࡜⣽⬊ࢫࣇ࢙ࣟ࢖ࢻࡢㄪ〇ࢆ㐍ࡵ࡚࠸ࡿ㸬ࡉࡽ࡟㸪⣽⬊ෆ࡬ࡢࢱࣥࣃࢡ㉁➼ࡢᑟධࡀື≀⣽⬊ࡼࡾ㞴ࡋ࠸࡜ࡉࢀࡿ᳜≀⣽⬊࡬ࡢࢤࣀ࣒⦅㞟⏝ࡢࢶ࣮ࣝࡢᑟධ࡟ࡶ╔ᡭࡋࡓ㸬⣽⬊⼥ྜ⏝࣐࢖ࢡࣟ࢔ࣞ࢖ᇶᯈ࡜ࣃࣝࢫ࣮ࣞࢨ࣮⿦⨨࡜ࡢే⏝࡟ࡼࡿ㧗ຠ⋡࡞ᮍ㋃ࡢᑟධ⋡ࡢ㐩ᡂࢆ┠ᣦࡍ㸬ࡲࡓ᧯సࡢ⮬ື໬ࢆど㔝࡟ධࢀࡓࣂ࢖࢜ࢳࣕࣥࣂ࣮ࢆྵࡴࣟ࣎ࢵࢺࡢస〇ࡶ㐍ࡵ㸪⣽⬊ᅇ཰ὶ㊰➼ࢆഛ࠼࡚⿦⨨ࢆస〇ࡋ࡚࠸ࡿ㸬࢚ࢫࢸࢵࢡᰴᘧ఍♫㸪ᗈᓥ኱Ꮫ⌮Ꮫ㒊㸪㛵す኱Ꮫ໬Ꮫ⏕࿨ᕤᏛ㒊ࡽ࡜ඹྠᐇ㦂ィ⏬ࢆ㐍ࡵ࡚࠸ࡿ㸬ࡲࡓ㸪⣽⬊࢔ࣞ࢖ࡢᗮ౯໬ࡸ⣽⬊デ᩿࣭ᅇ཰࣭⼥ྜࢆ࣮ࣘࢨ࣮࢝ࢫࢱ࣐࢖ࢬ໬ࡋࡓ⿦⨨ࡢ㛤Ⓨࡶᘬࡁ⥆ࡁ㐍ࡵ㸪ᐇ⏝໬᳨ウࢆ㐍ࡵࡿ㸬－ 37 －ࣄࢺ⣽⬊ᰴࡢ฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲ ᒣ⏣ 㸺┠ⓗ㸼᪥ᮏ㓇ᡂศࡢ୰ࡢ᭷ຠᡂศࡢᵓ㐀Ỵᐃࢆ⾜࠸㸪ࢧࣉ࣓ࣜࣥࢺ㸪་⸆࡬ࡢᛂ⏝ࢆ᳨ウࡍࡿ㸬㸦ᒣ⏣㸧㸦⌧≧࡜⤖ᯝ㸧᪥ᮏ㓇ᡂศࡢศ⏬࡜࣓ࢱ࣮࣒࣎ࣟゎᯒࢆ⾜࠸㸪ࣄࢺࡢ╧╀ࡸᢠ୙Ᏻຠᯝ࡟㔜せ࡞ാࡁࢆࡋ࡚࠸ࡿ GABAA ཷᐜయάᛶཬࡧ NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ㸪࢝ࣉࢧ࢖ࢩࣥཷᐜయ࡟ᑐࡍࡿ᪥ᮏ㓇ᡂศࡢຠᯝࢆ᳨ウࡋࡓ㸬ཷᐜయࡢ㜼ᐖάᛶࡸసືάᛶࡀᚓࡽࢀࡓ≀㉁࡟ࡘ࠸࡚ࡑࡢຠᯝࢆヲ⣽࡟᳨ウࡋࡓ㸬GABAA ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 16 ᡂศぢฟࡋࡓ㸬ࡇࢀࡲ࡛㸪㙠㟼࣭ദ╀⸆㸪ᢠ②ᨥ⸆ࡸᢠ୙Ᏻ⸆ࡣ໬Ꮫ≀㉁࡛࠶ࡗࡓࡀ㸪௒ᅇぢࡘࡅࡓ≀㉁ࡣྂ᮶ࣄࢺࡀᦤྲྀࡋ࡚ࡁࡓ᪥ᮏ㓇࡟ྵࡲࢀࡿኳ↛ᡂศ࡛࠶ࡾ㸪⏕యෆ࡟ࡶᬑ㐢ⓗ࡟Ꮡᅾࡍࡿࡶࡢࡀከ࠸ࡓࡵ㸪⸆࡜ࡋ࡚ࡶ
Ᏻ඲ᛶࡀ㧗ࡃ㸪ࡲࡓᶵ⬟ᛶ㣗ရ࡬ࡢᛂ⏝ࡶྍ⬟࡛࠶ࡿ㸬ࡇࡢ◊✲ࡢ⤖ᯝࡣᢞ✏ࡋฟ∧ࡉࢀࡓ㸬
NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 13 ᡂศぢฟࡋ㸪ࡑࡢෆࡢ 10 ᡂศࡣ᪂つ≀㉁࡛࠶ࡗࡓ㸬ᖹᡂ 28 ᖺ᪥ᮏ⸆⌮Ꮫ఍ཬࡧᖹᡂ 28 ᖺᗘ᪥ᮏ㎰ⱁ໬Ꮫ఍኱఍࡟࡚ࡑࡢᡂ
ᯝࢆⓎ⾲ࡋࡓ㸬࢝ࣉࢧ࢖ࢩࣥཷᐜయ࡟ࡘ࠸࡚ࡶ㸪᪥ᮏ㓇ᡂศ୰࠿ࡽ᪂ࡓ࡟ཷᐜయ࡟స⏝ࡍࡿ 10 ≀㉁ࢆⓎぢࡋࡓ㸬 ◊✲ィ⏬ ௒ᚋࡶᘬࡁ⥆ࡁ㸪᪥ᮏ㓇࡟ྵࡲࢀࡿ᭷ຠᡂศࡢ GABAA ཷᐜయ㸪NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡬ࡢຠᯝࢆ᳨ウࡋ㸪ࡉࡽ࡟㎞࿡࡜③ࡳ࡟㛵ಀࡋࡓཷᐜయ࡛࠶ࡿࣄࢺࡢ࢝ࣉࢧ࢖ࢩࣥཷᐜయ࡟స⏝ࡍࡿ≀㉁࡟ࡘ࠸࡚ࡶ᳨ウࡍࡿணᐃ࡛࠶ࡿ㸬⤖ᯝ࡟ᇶ࡙ࡁ㸪⚄⤒⣔⣽⬊࡬ࡢ┤᥋ຠᯝࡸ㸪ື≀ᐇ㦂㸦ཷືᅇ㑊ヨ㦂㸪㧗ᯫᘧ༑Ꮠ㏞㊰ヨ㦂㸧ࢆ⾜࠸㸪⚄⤒ᶵ⬟࡬ࡢຠᯝࢆ᳨ドࡍࡿ㸬࠾Ⲕ㸪⡿࡞࡝ࡢ᳜≀⏤᮶ࡢ㤶Ẽᡂศ㸪⏕⌮άᛶ≀㉁ࡢ⚄⤒⣔⣽⬊࡬ࡢຠᯝࢆ᳨ウࡍࡿ㸺┠ⓗ㸼⣽⬊ࢆ⏝࠸ࡓ་⸆ရ㸪ಖ೺ᶵ⬟㣗ရ࡬ࡢ㛤Ⓨࢆ┠ᣦࡋࡓ㓇ྵ᭷ᡂศ㸪࣌ࣉࢳࢻ㢮㸪ࣅࢱ࣑ࣥ㸪₎᪉ᡂศ㸪Ⲕᡂศ࡞࡝㣗ရ୰࡟ྵࡲࢀࡿ᪂つ⏕⌮άᛶ≀㉁ࡢ᳨⣴ ⌧≧࡜⤖ᯝ ࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ㸪ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥࡢㄏᑟయ㸪⢾㢮ࡢຠᯝࢆ᳨ウࡋࡓ㸬ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ࡜ࡑࡢㄏᑟయཬࡧࣉ࣏ࣟࣜࢫ࡜ࡑࡢྵ᭷ᡂศ࡟⚄⤒ẘཬࡧ㓟໬ࢫࢺࣞࢫ࡟ᑐࡍࡿಖㆤస⏝ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸬ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ࡜ࡑࡢㄏᑟయࡢ◊✲ࡣ୕⳻⎰᪁໬Ꮫᰴᘧ఍♫ࡢ༠ຊࢆᚓ࡚㸪JST ࡢࠕ◊✲ᡂᯝᒎ㛤஦ᴗ࣐ࢵࢳࣥࢢࣉࣛࣥࢼ࣮ࣉࣟࢢ࣒ࣛࠕ௻ᴗࢽ࣮ࢬゎỴヨ㦂 ࠖ࡟᥇ᢥࡉࢀࡓ㸬▼ᕝ┴ᕤᴗヨ㦂ሙ࡜࡯࠺ࡌⲔࡢࡶࡘ᭷ຠᡂศ࡟ࡘ࠸࡚ࡶ᳨ウ୰࡛࠶ࡿ㸬        ◊✲ィ⏬ ௒ᚋࡶࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪⣽⬊ಖㆤస⏝ࢆࡶࡘ≀㉁ࢆ㣗ရ୰࠿ࡽぢࡘࡅ㸪ࡑࡢస⏝ᶵᗎࢆ᳨ウࡍࡿணᐃ࡛࠶ࡿ㸬࡯࠺ࡌⲔࡢᡂศ࡟ࡘ࠸࡚᪂つ⏕⌮άᛶࡀぢࡽࢀࡓࡓࡵ㸪≉チ⏦ㄳࡢணᐃ࡛࠶ࡿ㸬ࡲࡓ㸪₎᪉⸆୰ࡢᡂศ࡟ࡘ࠸࡚ࡶ᳨ウணᐃ࡛࠶ࡿ㸬－ 38 －⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢຠᯝⓗ࡞฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲㸦Ώ㑓㸧㸺┠ⓗ㸼 ᆅᇦ࡛≉⏘ࡉࢀࡿ㎰Ỉ⏘≀㸪≉࡟ᮍ฼⏝࡞⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢᶵ⬟ࡢ௜ຍ㸪ྥୖ࠾ࡼࡧᨵኚࢆᐇ⌧ࡍࡿࡓࡵࡢ⏕≀໬ᏛᕤᏛⓗࣉࣟࢭࢫࡢᵓ⠏㸦⌧≧࡜⤖ᯝ㸧ᾏⱏ⏤᮶ࣇ࢕ࢥࣅࣜࢱࣥࣃࢡ㉁ࡢỈ⁐ᾮ୰࡛ࡢⰍㄪኚ໬࡟ཬࡰࡍ࢚ࢱࣀ࣮ࣝࡸ pH ࡢᙳ㡪ࡀ᳨ウࡉࢀ㸪࢔ࣝࢥ࣮ࣝ㣧ᩱ࡞࡝࡬ࡢ฼⏝ࡢྍ⬟ᛶࡀ♧ࡉࢀࡓ㸬෾⤖࣭ゎ෾ࢆ⤒ࡓࣇ࣮ࣞࣂ࣮࣭࣐࢖ࢡࣟ࢝ࣉࢭࣝࡢᏳᐃᛶゎᯒ࠿ࡽࡣ㸪ྠࡌࡃࣇ࣮ࣞࣂ࣮ࢆྵࡴỈ୰Ἔ⁲ᆺ࢚࣐ࣝࢩࣙࣥࡢᏳᐃᛶ࡟㢮ఝࡋࡓ≉ᛶ࡜┦㐪Ⅼࡀࡑࢀࡒࢀ♧ࡉࢀ㸪୙Ᏻᐃ໬࡟ᙳ㡪ࡍࡿᅉᏊࡀᥦ᱌ࡉࢀࡓ㸬⬡㉁ࢆ୺య࡜ࡋࡓ㧗㱋⪅⏝㣗ရࡢ㛤Ⓨ࡟ྥࡅࡓ᳨ウ࡛ࡣ㸪ከ⢾࡟ࡼࡾㄪ〇ࡉࢀࡓࢰࣝࡢ≀ᛶ࡜Ᏻᐃᛶ࡜ࡢ㛵ಀࡀ♧ࡉࢀࡓ㸬࢔ࣝ࢝ࣜ␗ᛶ໬ࢆ฼⏝ࡋࡓᕼᑡ⢾ࡢ⏕⏘࡛ࡣ㸪ᅇศἲ࡟࠾࠸࡚࢞ࣛࢡࢺ࣮ࢫࢆᇶ㉁࡜ࡋࡓࢱ࢞ࢺ࣮ࢫࡸࢱ࣮ࣟࢫࡢྜᡂ
ࡀ☜ㄆࡉࢀࡓ㸬ບ㉳⺯ග࣐ࢺࣜࢡࢫࢆ⏝࠸ࡓ⡿ࡢ㠀◚ቯရ㉁ホ౯࡟࠾࠸࡚ࡣ㸪≉ᐃࡢບ㉳࣭⺯ගἼ㛗࡛ࡢᙉᗘ ᐃ࡜ࡑࡢ⤫ィゎᯒ࠿ࡽ㸪⡿୰ࡢ⬡㉁ࡢ≧ែࢆ཯ᫎࡍࡿရ㉁࣭㩭ᗘホ౯ࡀྍ⬟࡜࡞ࡗࡓ㸬ᗫᲠẟ㧥ࡢ᭷ຠ฼⏝ἲࡢ᳨ウ࡛ࡣ㸪ள⮫⏺Ỉฎ⌮ࡢᑟධ࡟ࡼࡾࡑࡢపศᏊ໬ࡀ☜ㄆࡉࢀ㸪ศゎ཯ᛂࡢ ᗘ౫Ꮡᛶࡀ♧ࡉࢀࡓ㸬㸦◊✲ィ⏬㸧ᾏⱏ⏤᮶ࣇ࢕ࢥࣅࣜࢱࣥࣃࢡ㉁ࡢᐇ⏝ⓗ࡞฼⏝࡟ࡘ࠸࡚ᙧែ࡟≉໬ࡋࡓ᳨ウࢆ㐍ࡵ࡚࠸ࡃ㸬ࢰ࡛ࣝࡢ▱ぢࢆཧ⪃࡟ࡋ࡚㸪ࢤࣝ≧ែࡢ⬡㉁୺య㧗㱋⪅⏝㣗ရࡢ㛤Ⓨ࡟ྥࡅࡓ᳨ウࢆ⾜ࡗ࡚࠸ࡃ㸬ࡇࡢ㝿࡟㸪ࡇࢀࡲ࡛࡟฼⏝ࡋ࡚࠸࡞࠸≀ᛶ ᐃࢆヨ⾜ࡍࡿ㸬࢔ࣝ࢝ࣜ␗ᛶ໬཯ᛂ࡛౑⏝ࡍࡿ㝜࢖࢜ࣥ஺᥮ᶞ⬡ࡢ≉ᛶࢆ ᐃࡋ㸪ᅇศ཯ᛂ࡛ࡢ⏕⏘ᛶ࡜ࡢ㛵ಀ࡟ࡘ࠸࡚᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟㸪ὶ㏻ᘧ཯ᛂ࡬ࡢᒎ㛤ࢆ㐍ࡵࡿ㸬⡿ࡢ㠀◚ቯရ㉁ホ౯ἲࡢ㛤Ⓨ࡟࠾࠸࡚ࡣ㸪᪂⡿ࡔࡅ࡛࡞ࡃྂ⡿࡟㛵ࡍࡿࢹ࣮ࢱࢆ⵳✚ࡋ㸪⤫ィゎᯒᡭἲࢆᕤኵࡍࡿࡇ࡜࡟ࡼࡾ᪂つ࡞ホ౯ἲࡢ☜❧ࢆ┠ᣦࡍ㸬ள⮫⏺Ỉฎ⌮࡟ࡼࡿẟ㧥࠾ࡼࡧࢣࣛࢳࣥ࠿ࡽࡢ⏕ᡂ≀ࡢྠᐃࢆヨࡳ㸪ࡑࡢ฼⏝ࡢࡓࡵࡢྛ✀཯ᛂࡢヨ⾜ࢆ⾜࠺࡜࡜ࡶ࡟㸪⮳㐺཯ᛂ᮲௳ࢆỴᐃࡍࡿ㸬༡࢝ࣜࣇ࢛ࣝࢽ࢔኱Ꮫ␃Ꮫ୰㸦ᑠᕝ㸧࢖࢜ࣥᾮయࢆά⏝ࡋࡓ࣏ࣝࣇ࢕ࣜࣥ㢮໬ྜ≀ࡢྜᡂ࠾ࡼࡧ㔠ᒓ㘒య໬㸦໭ᒸ㸧㸺┠ⓗ㸼 ࢖࢜ࣥᾮయࢆ཯ᛂ⁐፹࡜ࡋ࡚ά⏝ࡋ㸪࣏ࣝࣇ࢕ࣜࣥ㢮໬ྜ≀ࡢຠᯝⓗ࠿ࡘ⎔ቃ࡟ඃࡋ࠸ྜᡂἲ࡞ࡽࡧ࡟㔠ᒓ㘒య໬ࡢᡭἲࢆ㛤Ⓨ㸦⌧≧࡜⤖ᯝ㸧Adler ἲ㸪Lindsey ἲ࡞࡝㧗཰⋡࡟࣏ࣝࣇ࢕ࣜࣥࢆྜᡂࡍࡿᡭἲࡀᏑᅾࡍࡿࡀ㸪ࣁࣟࢤࣥ⁐፹ࡸᙉ㓟㸪࢟ࣀࣥ⣔ࡢ㓟໬๣࡞࡝⎔ቃ࡟㈇Ⲵࢆ࠿ࡅࡿヨ⸆ࢆ౑⏝ࡍࡿᚲせࡀ࠶ࡿ㸬ࡇࢀ࡟ᑐࡋ㸪ᮏ◊✲࡛ࡣ࢖࢜ࣥᾮయࢆ㐺ᛂࡍࡿࡇ࡜࡛⎔ቃ࡟ඃࡋࡃࢸࢺࣛࣇ࢙ࢽ ࣝ ࣏ ࣝ ࣇ࢕ ࣜ ࣥ㸦 ௨ᚋ TPP㸧 ࢆ ྜ ᡂࡍ ࡿ ᡭἲ ࢆ 㛤 Ⓨ ࡋ࡚ ࡁ ࡓ㸬 ᙉ㓟 ࡛ ࠶ ࡿ [C4 Ѹ
SO3HC4im][CF3SO3]ࢆࢪࢡ࣓ࣟࣟࢱࣥ࡜┦ศ㞳ࡋࡓ஧┦⣔཯ᛂ࡟㐺ᛂࡍࡿࡇ࡜࡛㸪཯ᛂ⁐፹࡛࠶ࡿࢪࢡ࣓ࣟࣟࢱࣥࢆ 1/15 ๐ῶࡋ࡚ࡶຠᯝⓗ࡟ TPP ࡀ⏕ᡂࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㸬ࡲࡓ㸪࢖࣑ࢲࢰ࣮ࣝᆺࡢ[HC4im][CF3CO2]ࢆ཯ᛂ⁐፹࡜ࡍࡿࡇ࡜࡛㸪ຠᯝⓗ࡟ TPP ࡀ⏕ᡂࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ㸬ࡇࡢᡭἲ࡛ࡣ཯ᛂᚋࡢ࢖࢜ࣥᾮయࢆຠ⋡ࡼࡃ෌฼⏝࡛ࡁࡿ－ 39 －ࡇ࡜࠿ࡽ㸪ᗫ㓟ࡢฟ࡞࠸཯ᛂ⣔ࡢᵓ⠏࡟ᡂຌࡋࡓ㸬㸦◊✲ィ⏬㸧࢖࢜ࣥᾮయࢆά⏝ࡋࡓ࣏ࣝࣇ࢕ࣜࣥྜᡂ㸸ᘬࡁ⥆ࡁ㸪TPP ௨እࡢ࣏ࣝࣇ࢕ࣜࣥ㢮໬ྜ≀࡟ᑐࡋ࡚࢖࢜ࣥᾮయࢆά⏝ࡋࡓྜᡂἲࢆ㐺ᛂࡍࡿࡇ࡜୍࡛⯡ᛶࢆ⋓ᚓࡍࡿ㸬ࡲࡓ㸪㏻ᖖࡢྜᡂἲ࡛ࡣຠᯝⓗ࡟࣏ࣝࣇ࢕ࣜࣥࡀྜᡂ࡛ࡁ࡞࠸཯ᛂ⣔࡟㐺ᛂࡋ࡚࠸ࡃ㸬ࢸࢺࣛࣆࣜࢪ࣏ࣝࣝࣇ࢕ࣜࣥ(TPyP)࡞࡝ࡢྜᡂ࡟㐺ᛂࡋ㸪ຠᯝⓗ࠿ࡘ⎔ቃ࡟ඃࡋ࠸ྜᡂἲࢆᵓ⠏ࡍࡿ㸬࢖࢜ࣥᾮయ୰࡟࠾ࡅࡿ࣏ࣝࣇ࢕ࣜࣥࡢ㔠ᒓ㘒య໬㸸᪤࡟㸪㧗⃰ᗘ࡟ TPP ࢆ⁐ゎࡍࡿ࢖࢜ࣥᾮయࢆ⏝࠸ࢀࡤ㸪࣐࢖ࢡࣟἼࢆ⏝࠸ࡎ࡜ࡶຠᯝⓗ࡟ TPP ࡀ㔠ᒓ㘒య໬ࡉࢀࡿ஦ࢆぢฟࡋ࡚࠾ࡾ㸪᭱ࡶຠᯝⓗ࡟ TPP ࡀ㔠ᒓ㘒໬ࡍࡿ࢖࢜ࣥᾮయᵓ㐀ࢆ᫂ࡽ࠿࡟ࡍࡿ㸬ࡇࡢ◊✲࡛ࡣ㸪ྛ✀㔠ᒓሷ࡜ TPP ࡜ࡢ཯ᛂ࡟᭱㐺࡞࢖࢜ࣥᾮయᵓ㐀ࢆ≉ᐃࡍࡿ㸬TPP ࡢ⁐ゎᛶࡢ㧗ࡉࡀ㘽࡛࠶ࡾ㸪࢖࢜ࣥᾮయࡢ࢔ࣝ࢟ࣝ㙐㛗㸪㦵᱁㸪࢔ࢽ࢜ࣥᵓ㐀࡟↔Ⅼࢆᙜ࡚㸪TPPࡢ㔠ᒓ㘒య໬࡟᭱㐺࡞࢖࢜ࣥᾮయᵓ㐀ࢆ᥈⣴ࡍࡿ㸬ࡲࡓ㸪ࡼࡾ ࿴࡞཯ᛂ᮲௳ࢆ᥈⣴ࡋ㸪࢖࢜ࣥᾮయࡢ཯ᛂᚋࡢ෌฼⏝᪉ἲࢆ☜❧ࡍࡿࡇ࡜࡛㸪⎔ቃ࡟ඃࡋࡃ㸪Ᏻ඲࡛ຠᯝⓗ࡞࣏ࣝࣇ࢕ࣜࣥࡢ㔠ᒓ㘒య໬ࢆ☜❧ࡍࡿ㸬ࡲࡓ㸪TPP ௨እࡢ࣏ࣝࣇ࢕ࣜࣥ࡟ᮏᡭἲࢆᒎ㛤ࡋ㸪୍⯡ᛶࢆ⋓ᚓࡍࡿ㸬㸬ඹྠ◊✲㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸ᖹᡂ 28 ᖺᗘ㸦1 ௳㸸ᅜෆ௻ᴗ㸧2) ᒣ⏣ ᗣᯞ㸸ᖹᡂ 28 ᖺᗘࠕࢢࣝࢱ࣑ࣥ㓟ཷᐜయཬࡧ GABA ཷᐜయ࡟స⏝ࡍࡿ㓇ᡂศ࡟㛵ࡍࡿ◊✲ࠖ㸪⊂❧⾜ᨻἲே 㓇㢮⥲ྜ◊✲ᡤ㸬୺せ࡞◊✲ᴗ⦼  ⴭ᭩㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸ࣉࣛࢫࢳࢵࢡࡢ◚ᦆ࣭◚ቯ࣓࢝ࢽࢬ࣒࡜⪏⾪ᧁᛶྥୖᢏ⾡➨ 3 ⠇㧗ศᏊᮦᩱࡢ⪏⾪ᧁᛶྥୖ஦౛[1]⮬ື㌴ෆ⿦㒊ရ࡟౑࠼ࡿኳ↛ࢦ࣒」ྜ໬࡟
ࡼࡿ㧗ᙉᗘ࣏ࣜங㓟ᶞ⬡ࡢ㛤Ⓨ㸪pp250-258, (2017.2),ࢧ࢖࢚ࣥࢫ&ࢸࢡࣀࣟࢪ࣮ओ
2) Yamada Y. “Neurological activities of Linalool and other fragrant compounds. ”
Advances in Chemistry research, vol.34, pp33-48, Chapter 3, (2017.1), Nova
Science Publishers Inc.
 Ꮫ⾡ㄽᩥ㸦 ௳㸧1) ௒ᇛ ᫂඾㸪Ọᒸ ᚿ✑㸪ᓲ ※↵㸪Ọᓥ ṇႹ㸪ⓑ▼ ᾈᖹ㸪“⣽⬊⼥ྜ⏝ᇶᯈ࡜ࡋ࡚ࡢ⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖࡬ࡢ PEG ࡢᅛᐃ໬࡜⾲㠃ᛶ≧ࡢホ౯”㸪㏆␥኱Ꮫḟୡ௦ᇶ┙ᢏ⾡◊✲ᡤሗ࿌, 7, (2016), pp.59-64
2) Imajo A, Ito T, Nousou T, Shiraishi K, “Preparation of a UCST type of thermosresponsibe sulfobetaine polymer modified poly (ethylene terephthalate) films byAr plsma-post polymerization method and recovery of attached HeLa cells on thefilm by heating with laser irradiation”, Research Reports of the Faculty ofEngineering Kindai University, 50, (2016), pp.1-6－ 40 －3)

Izu H, Shigemori K, Eguchi M, Kawane S, Fujii S, Kitamura Y, Aoshima H,Yamada Y, “Direct activation of GABAA receptors by substances in the organicacid fraction of Japanese sake.” Food Chemistry 214, (2017), pp.354-359. Available
online 8 July 20164) ᒣ⏣ ᗣᯞ㸪“Ⴔዲရ࡟ࡼࡿ࢝ࣉࢧ࢖ࢩࣥཷᐜయࡢస⏝”㸪 AROMA RESEARCH 18 (1)㸪(2017), pp.48-51
5)

Watanabe Y, Khuwijitjaru P, Hamai Y, Wiboonsirikul J, Adachi S, “Antioxidative
property of acyl ascorbate in cookies containing iron.” Japan Journal of FoodEngineering, 17(2), (2016), pp.77-81
6)

Wiboonsirikul J, Watanabe Y, Omori A, Khuwijitjaru P, Adachi S, “Antioxidative
properties of stearoyl ascorbate in a food matrix system.” Journal of Oleo Science,65(6), (2016), pp.487-492

7)Ishigaki T, Ono S, Watanabe Y, “Oxidative stability of linoleoyl trehalose and theeffect on coexisting lipid”, Research Reports of the Faculty of Engineering Kindai

University, 50, (2016), pp.27-308)

Watanabe Y, “Enzymatic synthesis of amphiphilic acyl ascorbate and its
suppressive effect on lipid oxidation”, Proceedings of the II International

Conference on Food Chemistry & Technology, Journal of Food Chemistry &Nanotechnology, 2(4), (2016), S189) ᶓ㔝 ୍Ṍ㸪Ώ㑓 ⩏அ㸪㧗ὠ ᆅᚿ㸪⸨⏣ ᫂Ꮚ㸪㔝ᮧ ṇே㸪“⡿㣤୰ࡢ࢜ࣜࢦ⢾ྵ᭷㔞࡜㣗࿡࡜ࡢ㛵ಀ”, ⨾࿡ᢏ⾡Ꮫ఍ㄅ, 15 (2), (2016), pp.15-2010) Watanabe Y, Ishigaki T, Fujii S, Adachi S, “Suppressive effect of acyl ascorbate
coexistent with tocopherol on oxidation of linoleic acid.” Ascorbic Acid: Properties,Synthesis and Applications, Nova Science Publishers, Inc. NY, (2017), pp.91-104
11) Kitaoka S, Nobuoka K, Miura J, Ohga Y, Ishikawa Y, “First Observation for
Dynamic Solvent Effect in Ionic Liquids ”, Chem. Lett., 45(4), (2016), pp.385-387
12) Nobuoka K,Kitaoka S, Yamauchi T, Harran T, Ishikawa Y, “Photoresponsive IonicLiquids with an Azobenzene Moiety ”, 45(4), (2016), pp.433-435
 Ꮫ఍Ⓨ⾲㸦 ௳㸧1)㎰᐀ ㎮ᕫ㸪௒ᇛ ᫂඾㸪ᑠᆏ ୍㈗㸪ఀ⸨ ኱᫬㸪ᒣ⏣ ᗣᯞ㸪ⓑ▼ ᾈᖹ㸪“⾲㠃㛤ጞATRP ἲ࡛ UCST ᆺ ᗘᛂ⟅ᛶ࢔ࢡࣜࣝ࢔࣑ࢻ/࢔ࢡࣜࣟࢽࢺࣜࣝඹ㔜ྜయࢆಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ࣄࢺ㛫ⴥ⣔ᖿ⣽⬊(hiMSC)ࡢ

ᗘ่⃭ࡣࡃ㞳”㸪➨ 65 ᅇ㧗ศᏊᏛ఍ᖺḟ኱఍(2016-5)㸪⚄ᡞᅜ㝿఍㆟ሙ㸦⚄ᡞ㸧2) ụ⏣ Ṋⶶ㸪ඣᓥ ༓ᜨ㸪Ლᒣ ೺ḟ㸪㏕⏣ ஽㸪ⓑ▼ ᾈᖹ㸪ᯇᮏ ❶୍㸪“ࣜࣥ⬡㉁࣏ࣜ
࣐࣮ࢆࢥ࣮ࢺࡋࡓࣉࣛࢫࢳࢵࢡᇶᮦࡢᛶ⬟ホ౯”㸪➨ 12 ᅇ᥋╔Ꮫ఍ⱝᡭࡢ఍(2016-10)㸪
኱㜰3) ᑠᆏ ୍㈗㸪௒ᇛ ᫂඾㸪ᖹ஭ ඞᑦ㸪ⓑ▼ ᾈᖹ㸪“᪂つぶỈᛶሬ⭷࡟ࡼࡿ㔠ᒓ⾲㠃࡬ࡢಟ㣭࡜୙෾ᛶࡢホ౯”㸪➨ 31 ᅇ୰ᅜᅄᅜᨭ㒊㧗ศᏊⱝᡭ◊✲఍ࠕ㧗ศᏊࡢᵓ㐀࡜ᶵ⬟ࠖ
(2016-11)㸪࡜ࡾࡂࢇᩥ໬఍㤋㸦㫽ྲྀ㸧－ 41 －

4)

Ikeda M, Kojima C, Kajiyama K, Sakoda T, Shiraishi K, Matsumoto A,“Evaluation of adhesive properties and cell adhesion of MPC polymer-coatedsubtraretes”, 3rd International Conference on Biomaterials Science in Tokyo,2016(2016-11), Tokyo, Japan5)

Osaka K, Imajo A, Hirai N, Shiraishi K, “Metal Surface Coating withPolyioncomplexs and Evaluation of Antifreeze Properties”, 9th International
Conference on Green Composites, 2016 (2016-11), Kobe University, Kobe, Japan6)ụ⏣ Ṋⶶ㸪ඣᓥ ༓ᜨ㸪Ლᒣ ೺ḟ㸪㏕⏣ ஽㸪ⓑ▼ ᾈᖹ㸪ᯇᮏ ❶୍㸪“✀ࠎࡢᇶᮦୖ࡟ࢥ࣮ࢺࡋࡓࣜࣥ⬡㉁㢮ఝ࣏࣐࣮ࣜࡢ᥋╔≉ᛶホ౯”㸪ࠕࣂ࢖࢜࢖ࣥࢱ࣮ࣇ࢙࢖ࢫඛ➃࣐ࢸࣜ࢔ࣝࡢ๰⏕ࠖ➨ 7 ᅇࢩ࣏ࣥࢪ࣒࢘㸦኱㜰ᕷ❧኱Ꮫ㸧(2017-2)㸪࠶࡭ࡢ࣓ࢹ࢕ࢵࢡࢫ㸦኱㜰ᕷ❧኱Ꮫ㜿ಸ㔝࢟ࣕࣥࣃࢫ㸧㸦኱㜰㸧7)すᒃ ࿴ဢ㸪୰㊰ ᫀᚿ㸪୰す ្㸪ᒣ⏣ ᗣᯞ㸪“ࣄࢺ⚄⤒ⱆ⣽⬊⭘ᰴ SK-N-SH ࡟ᑐࡍࡿࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ㸦PQQ㸧࡜ࡑࡢㄏᑟయࡢຠᯝ”㸪᪥ᮏ㣗ရಖⶶ⛉Ꮫ఍➨ 65 ᅇ኱఍ (2016-6)㸪༡஑ᕞ኱Ꮫᐑᓮ࢟ࣕࣥࣃࢫ㸦ᐑᓮ㸧8)

Nishii K, Nakamichi M, Nomura H, Kubo K, Yamada Y, “Comparison of the effectsof pyrroloquinoline quinone and imidazole pyrroloquinoline on neural and hepaticcell lines”, The 5th International Conference on Cofactors (ICC-05) and Active9)

Enzyme Molecule 2016 (AEM 2016) (2016-9), Toyama, Japan▮྿ ᬛ㸪๎ໟ ₩ே㸪❧⁁ ༤ஓ㸪ఀ㇋ ⱥᜨ㸪ᒣ⏣ ᗣᯞ㸪“᪥ᮏ㓇ᡂศࡢ NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡬ࡢຠᯝ”㸪᪥ᮏ࢔࣑ࣀ㓟Ꮫ఍ 10 ࿘ᖺグᛕ኱఍ (2016-9)㸪ᮾி኱Ꮫ㸦ᮾி㸧10) Yamada Y, Shiraishi H, Nameda A, Arima Y, Nagao M, “The effect of anorganophosphorus agent on human neuroblastomaagent cell line SK-N-SH”,
Society for Neuroscience 45th Annual Meeting (2016-11), San Diego, U.S.A.
11) ▮྿ ᬛ㸪๎ໟ ₩ே㸪❧⁁ ༤㸪ఀ㇋ ⱥᜨ㸪ᒣ⏣ ᗣᯞ㸪“᪥ᮏ㓇ᡂศࡢ NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡬ࡢຠᯝ”㸪᪥ᮏ㎰ⱁ໬Ꮫ఍ 2017 ᖺᗘ኱఍(2017-3)㸪ி㒔ዪᏊ኱Ꮫ㸦ி㒔㸧12) ⏣㇂ 㑳ᐇ㸪஭ୖ ⤢ⵇ㸪ᒣ⏣ ᗣᯞ㸪“࢞ࣛࢡࢺࣜࢩࣝࢢࣜࢭ࣮ࣟࣝࡢࣄࢺ⾲⓶ゅ໬⣽⬊࡜⚄⤒⣔⣽⬊࡬ࡢಖㆤຠᯝࡢ᳨ウ”㸪᪥ᮏ㎰ⱁ໬Ꮫ఍ 2017 ᖺᗘ኱఍(2017-3)㸪ி㒔ዪᏊ኱Ꮫ㸦ி㒔㸧13) すᒃ ࿴ဢ㸪୰㊰ ᫀᚿ㸪୰す ្㸪ᒣ⏣ ᗣᯞ㸪“ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ࡜࢖࣑ࢲࢰࣆࣟࣟ࢟ࣀࣜࣥࡢ⚄⤒⣔⣽⬊࡬ࡢຠᯝࡢẚ㍑᳨ウ”㸪᪥ᮏ㎰ⱁ໬Ꮫ఍ 2017 ᖺᗘ኱఍(2017-3) ி㒔ዪᏊ኱Ꮫ㸦ி㒔㸧14) ᒣ⏣ ᗣᯞ㸪▮྿ ᬛ㸪すᒃ ࿴ဢ㸪๎ໟ ₩ே㸪ఀ㇋ ⱥᜨ㸪“NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟ᑐࡍࡿ࢔࣑ࣥ㢮ࡢຠᯝ”㸪➨ 90 ᅇ᪥ᮏ⸆⌮Ꮫ఍ᖺ఍ (2017-3)㸪㛗ᓮࣈࣜࢵࢡ࣮࣍ࣝ㸦㛗ᓮ㸧15) Watanabe Y, “Antioxidative properties of acyl ascorbates in bulk oil, oil-in-water
emulsion and microcapsule”, Energy, Material and Nanotechnology 2016 Droplet,(2016-5), San Sebastian, Spain16) Okubayashi T, Kono Y, Hiroshima M, Watanabe Y, “Effect of freezing and thawing－ 42 －

processes on stability of O/W emulsion with flavor component”, 18th World
Congress of Food Science and Technology, (2016-8), Dublin, Ireland17) Watanabe Y, “Enzymatic synthesis of amphiphilic acyl ascorbate and its
suppressive effect on lipid oxidation”, 2nd International Conference on Food
Chemistry and Technology (2016-11), Las Vegas, U.S.A.
18) Kitaoka S, Nobuoka K, Inoue T㸪“Phthalocyanine preparation utilizing ionicliquids”㸪26th EUCHEM Conference on Molten Salts and Ionic Liquids (2016-7),
Wien, Austria .
19) ᇼ ဴ㑻㸪໭ᒸ ㈼㸪“࢖࢜ࣥᾮయࢆά⏝ࡋࡓ TPP ࡢ㔠ᒓ㘒య໬”㸪➨ 27 ᅇ ᇶ♏᭷ᶵ໬Ꮫウㄽ఍ (2016-9), ᗈᓥ኱Ꮫ㸦ᗈᓥ㸧20) ໭ᒸ ㈼㸪ఀ⃝ ఙኴᮁ㸪ಙᒸ ࠿࠾ࡿ㸪“࢖࢜ࣥᾮయࢆά⏝ࡋࡓࣇࢱࣟࢩ࢔ࢽࣥྜᡂἲࡢ㛤Ⓨ”㸪➨ 46 ᅇ 」⣲⎔໬Ꮫウㄽ఍ (2016-9), 㔠ἑḷ๻ᗙ㸦▼ᕝ㸧21) Kitaoka S, Yamamoto A, Hori T, Nobuoka K, “Efficient Synthesis of Porphyrin inthe Acidic Ionic Liquids”㸪Asian Conference on Engineering and Natural Science
ACENS2017 (2017-1), Sapporo, Japan22) Kitaoka K, Izawa S, Nobuoka K, “Phthalocyanine preparation utilizing ionicliquids”㸪᪥ᮏ໬Ꮫ఍➨ 97 ᫓Ꮨᖺ఍ (2017-3), ៞᠕⩏ሿ኱Ꮫ㸪㸦ᶓ὾㸧 ㅮ₇㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸ࣂ࢖࣐࢜ࢫ㛵㐃㛤Ⓨ஦ᴗ᥎㐍఍㆟࣭ࣂ࢖࣐࢜ࢫ฼⏝ᢏ⾡◊✲Ⓨ⾲఍࣭ࣂ࢖࣐࢜ࢫ⏘ᴗேᮦ⫱ᡂㅮᗙ ࠕࢭ࣮ࣝࣟࢫࢼࣀࣇ࢓࢖ࣂ࣮(CNF)➼ࢼࣀᚤ⢏Ꮚࡢ᪂つ࡞⾑ᾮจᅛホ౯ヨ⸆࡬ࡢᛂ⏝ࠖ㸪(2016-8)㸪┿ᗞࣂ࢖࣐࢜ࢫࣛ࣎㸦ᒸᒣ㸧2) ⓑ▼ ᾈᖹ㸸BioJapanࠕ⣽⬊࢔ࣞ࢖࡜࣮ࣞࢨ࣮↷ᑕࢩࢫࢸ࣒ࢆ⏝࠸ࡿࣁ࢖ࢫ࣮ࣝࣉࢵ
ࢺ⣽⬊デ᩿࣭ᅇ཰ཬࡧ㧗ຠ⋡⣽⬊⼥ྜࡢ⤫ྜ໬⿦⨨ࡢ㛤Ⓨࠖ㸪(2016-10)㸪ࣃࢩࣇ࢕ࢥᶓ὾㸦ᮾி㸧3) ⓑ▼ ᾈᖹ㸸୰ᅜᆅᇦࡉࢇࡉࢇࢥࣥࢯⓎࣛ࢖ࣇࢧ࢖࢚ࣥࢫ᪂ᢏ⾡ㄝ᫂఍ࠕ⏕యᛂ⟅ࢆไᚚࡍࡿࣂ࢖࣐࢜ࢸࣜ࢔ࣝཬࡧ᪂つ࣮ࣞࢨ࣮⺯ග㢧ᚤ㙾⿦⨨࡟ࡼࡿ⣽⬊デ᩿㸭ᅇ཰㸭⼥ྜ࡜⾑ᾮจᅛデ᩿ࠖ㸪(2016-11)㸪 JST ᮾிᮏ㒊ู㤋㸦ᮾி㸧4) ⓑ▼ ᾈᖹ㸸ᖹᡂ 28 ᖺᗘࠕᗈᓥࣜࢧ࣮ࢳࢥࣥࣉࣞࢵࢡࢫ᥎㐍༠㆟఍Ⓨ఍グᛕ⏘⥲◊୰ࠕ⏕యᛂ⟅ࢆไᚚࡍࡿࣂ࢖࣐࢜ᅜࢭࣥࢱ࣮ࢩ࣏ࣥࢪ࣒࢘࠙㹼⏕࿨⛉Ꮫࡢ㠉᪂ⓗᒎ㛤㹼ࠚࢸࣜ࢔ࣝ࡜᪂つ࣮ࣞࢨ࣮㢧ᚤ㙾ࢆ⏝࠸ࡓ⣽⬊デ᩿㸭ᅇ཰㸭⼥ྜࠖ㸪(2017-2)㸪ᗈᓥࢭࣥࢳ࣮ࣗࣜ21 ࣍ࢸࣝ㸦ᗈᓥ㸧5) ᒣ⏣ ᗣᯞ㸸ᕤᏛ㒊◊✲බ㛤ࣇ࢛࣮࣒ࣛࠕD-6 ࠾㓇࡟ྵࡲࢀࡿ᭷ຠᡂศࠖ
㸪(2016-10)㸪
ᒎ♧ࢭࢵࢩࣙࣥ㸪࣍ࢸ࣓ࣝࣝࣃࣝࢡᗈᓥ㸦ᗈᓥ㸧6) ᒣ⏣ ᗣᯞ㸸▱㈈஦ᴗ໬࣮࣡ࢡࢩࣙࢵࣉ㸪(2016-11)㸪ᗈᓥࢢࣛࣥࢻ࢖ࣥࢸࣜࢪ࢙ࣥࢺ࣍ࢸࣝ㸦ᗈᓥ㸧7) Ώ㑓 ⩏அ㸸 බ㈈ ࢯࣝࢺ࣭ࢧ࢖࢚ࣥࢫ㈈ᅋ➨ 28 ᅇຓᡂ◊✲Ⓨ⾲఍ࠕሷࡀ࿴㢼ฟỒࡢ᪨࿡࠾ࡼࡧ㤶Ẽᡂศ࡟ཬࡰࡍᙳ㡪ࠖ㸪(2016-7)㸪㒔ᕷࢭࣥࢱ࣮࣍ࢸࣝ㸦ᮾி㸧8) ໭ᒸ ㈼㸸 ᖹᡂ 28 ᖺᗘ㏆␥኱ᏛᕤᏛ㒊⏘Ꮫ㐃ᦠ᥎㐍༠ຊ఍ᢏ⾡Ⓨ⾲఍ࠕ࢖࢜ࣥᾮయ࡜
ࡑࡢᛂ⏝ࠖ㸪(2016-6)㸪࣍ࢸ࣓ࣝࣝࣃࣝࢡᗈᓥ ᗈᓥ－ 43 － ≉チฟ㢪㸦 ௳㸧ᅜ㝿≉チฟ㢪 PCT/JP2016/069696㸦Ⓨ᫂⪅㸸ⓑ▼ ᾈᖹ㸧 ≉チⓏ㘓㸦 ௳㸧≉チ➨ 6118601 ྕ ⣽⬊ฎ⌮⏝ᇶᯈ㸦Ⓨ᫂⪅㸸ⓑ▼ ᾈᖹ㸪ᒣ⏣ ᗣᯞ ௚㸧 ࡑࡢ௚㸦 ௳㸧1) ⓑ▼ ᾈᖹ㸸ඹྠ࣭ཷク◊✲ሗ࿌᭩㸦5 ௳㸧2) ⓑ▼ ᾈᖹ㸸௻ᴗ➼ᢏ⾡ᣦᑟ㸦11 ௳㸧3) Ώ㑓 ⩏அ㸸ཷク◊✲ሗ࿌᭩㸦4 ௳㸧4) Ώ㑓 ⩏அ㸸“ᚤ”ࡢどⅬ࡛“⨾”ࢆ㏣ồࡍࡿྲྀࡾ⤌ࡳ”, ⏕≀ᕤᏛ఍ㄅ, 94 (11), (2016), 715) ⓑ▼ ᾈᖹ㸸“Ꮫ㆑⤒㦂⪅ࡢ‫۔‬ᐤ✏‫࣭⏘ࠕ۔‬Ꮫ࣭ᐁ㐃ᦠඹྠ㛤Ⓨࢆ㏻ࡌ࡚ࡢ኱Ꮫ㸦㝔㸧ᩍ⫱࡬ࡢᣮᡓ”㸪㸦බ㈈㸧ࡕࡹ࠺ࡈࡃ⏘ᴗ๰㐀ࢭࣥࢱ࣮఍ሗ, 112, (2017), pp5-8
㸬እ㒊㈨㔠⋓ᚓ㸦 ௳㸧࠙➇தⓗ㈨㔠ࠚ1) ᒣ⏣ ᗣᯞ㸸ᅜ❧◊✲㛤Ⓨἲே⛉Ꮫᢏ⾡᣺⯆ᶵᵓ ᖹᡂ 28 ᖺᗘ◊✲ᡂᯝᒎ㛤஦ᴗ࣐ࢵࢳࣥࢢࣉࣛࣥࢼ࣮ ࣉࣟࢢ࣒ࣛࠕ௻ᴗࢽ࣮ࢬゎỴヨ㦂 ࠖ                     2) ᒣ⏣ ᗣᯞ㸸㏆␥኱Ꮫ 21 ୡ⣖◊✲㛤Ⓨዡບ㔠㸦ᖹᡂ 26㹼28 ᖺ㸧㸦௦⾲⪅:⏘ᴗ⌮ᕤᏛ㒊⸨஭ ᨻᖾᩍᤵ㸧3)Ώ㑓 ⩏அ㸸⛉Ꮫ◊✲㈝ຓᡂ஦ᴗ㸦Ꮫ⾡◊✲ຓᡂᇶ㔠㸧ᇶ┙◊✲(C)㸪
ࠕ㣗ရ࡜ࡋ࡚ࡢ⬡㉁ࡢ㧗ᗘ฼⏝࡜ࡑࡢရ㉁ຎ໬ᶵᵓࡢゎ᫂ࠖ㸪26450184㸪ᖹᡂ 26 ᖺᗘ㹼28 ᖺᗘ㸦௦⾲⪅㸧4) ໭ᒸ ㈼㸸 බ㈈ ࢧࢱࢣᢏ⾡᣺⯆㈈ᅋᖹᡂ 28 ᖺᗘ኱Ꮫ◊✲ຓᡂࠕGABA ࡢ࢖࢜ࣥᾮయ໬࡟ࡼࡿయෆ྾཰ࡢಁ㐍࡜ᶵ⬟ᛶ㣗ရ࡬ࡢᛂ⏝ࠖ㸦௦⾲⪅㸧5) ໭ᒸ ㈼㸸⛉Ꮫ◊✲㈝ຓᡂ஦ᴗ㸦Ꮫ⾡◊✲ຓᡂᇶ㔠㸧ᇶ┙◊✲(C)㸪
ࠕ࢖࢜ࣥᾮయࡀษࡾ㛤ࡃ࣏ࣝࣇ࢕ࣜࣥ཯ᛂሙࡢࣇࣟࣥࢸ࢕࢔ࠖ㸪16K05874㸪ᖹᡂ 28 ᖺᗘ㹼30 ᖺᗘ㸦௦⾲⪅㸧࠙ᐤ㝃࣭ጤク◊✲㈝ࠚ
1) ⓑ▼ ᾈᖹ㸸ᐤ㝃◊✲㸦1 ௳㸧㸪ጤク◊✲㸦4 ௳㸧2) ᒣ⏣ ᗣᯞ㸸ጤク◊✲㸦2 ௳㸧3) Ώ㑓 ⩏அ㸸ጤク◊✲㸦1 ௳㸧㸬Ꮫእවົᴗົ
1) ⓑ▼ ᾈᖹ㸸 㸦බ♫㸧㧗ศᏊᏛ఍୰ᅜᅄᅜᨭ㒊ᖿ஦ 㸦බ♫㸧➨66ᅇ㧗ศᏊウㄽ఍㸦ឡ፾㸧㐠Ⴀጤဨ2)ᒣ⏣ᗣᯞ㸸᪥ᮏ㣗ရ࣭ᶵᲔ◊✲఍⌮஦㸦බ♫㸧᪥ᮏ⸆⌮Ꮫ఍ホ㆟ဨ－ 44 －3)Ώ㑓⩏அ㸸㸦බ♫㸧᪥ᮏἜ໬Ꮫ఍௦㆟ဨ㸪㛵すᨭ㒊ᖖ௵ᖿ஦㸦බ♫㸧᪥ᮏ㣗ရ⛉ᏛᕤᏛ఍ⱥᩥㄅ⦅㞟ጤဨ㸦୍♫㸧᪥ᮏ㣗ရᕤᏛ఍⦅㞟ጤဨ4) ໭ᒸ㈼㸸」⣲⎔໬Ꮫウㄽ఍ୡヰே㸦බ♫㸧㧗ศᏊᏛ఍୰ᅜᅄᅜᨭ㒊ⱝᡭ◊✲఍㐠Ⴀጤဨ㸬ࡑࡢ௚1) ⓑ▼ ᾈᖹ㸸BioJapan ෌⏕་⒪ JAPAN2016㸫ฟᒎ㸦࣮ࣜࢻ࢚ࢢࢪࣅࢪࣙࣥࢪࣕࣃࣥओ㸧
㸪2016.10.12㹼2016.10.14㸪ࣃࢩࣇ࢕ࢥᶓ὾2) ⓑ▼ ᾈᖹ㸪ᑠᕝ ᬛᘯ㸸රᗜ┴❧㉥✑ᕷ❧᭷ᖺ୰Ꮫᰯ ᩍ⫱㐃ᦠ⌮⛉ᤵᴗࠕ㓟ሷᇶࠖࠕ࢚࢝ࣝࡢཷ⢭༸ࡢほᐹࠖ㸪2016.8.93) aCYBER ࢭࣥࢱ࣮:㸦ᅜ◊㸧⏘⥲◊୰ᅜࢭࣥࢱ࣮㸭aCYBER ࢭࣥࢱ࣮ࢪࣙ࢖ࣥࢺ࣑࣮ࢸ࢕ࣥࢢ㸪2016.3.27
  ᖹᡂ 28 ᖺᗘ⏘ᴗᢏ⾡⥲ྜ◊✲ᡤ୰ᅜࢭࣥࢱ࣮ཬࡧᗈᓥ኱Ꮫ࡟ࡼࡗ࡚⌮໬Ꮫ◊✲ᡤࡢ୍㒊ᶵ⬟ࡢᮾᗈᓥᕷ⛣㌿ࢆዎᶵ࡜ࡋ࡚ࠕᗈᓥࣜࢧ࣮ࢳࢥࣥࣉࣞࢵࢡࢫ᥎㐍༠㆟఍ࠖࡀタ❧ࡉࢀࡲࡋࡓ㸬ᙜᆅ࡟❧ᆅࡍࡿ㸪ᗈᓥ኱Ꮫ㸪㏆␥኱Ꮫ➼ࡢ኱Ꮫᶵ㛵ࡸ㸪㸦⊂㸧㓇㢮⥲ྜ◊✲ᡤ㸪㸦ᅜ◊㸧⏘⥲◊㸪㸦ᅜ◊㸧⌮໬Ꮫ◊✲ᡤࡀ┦஫ࡋ㸪␗ศ㔝⼥ྜ࡟ࡼࡿ᭱ඛ➃ࡢ」ྜᆺ࢖ࣀ࣮࣋ࢩࣙࣥ᥎
㐍ᇶ┙㸦ࣜࢧ࣮ࢳࢥࣥࣉࣞࢵࢡࢫ㸧ࡢᙧᡂ࡟ྲྀࡾ⤌ࡳࡀጞࡲࡾࡲࡋࡓ㸬ᮏ఍ࡣࣜࢧ࣮ࢳࢥࣥࣉࣞࢵࢡࢫ᥎㐍ࡢ୍⎔࡜ࡋ࡚㸪㸦ᅜ◊㸧⏘⥲◊୰ᅜࢭࣥࢱ࣮㸦ᮦᩱ࣭໬Ꮫ㡿ᇦᶵ⬟໬Ꮫ㒊㛛㸧࡜㏆␥኱Ꮫḟୡ௦ᇶ┙ᢏ⾡◊✲ᡤ㸦ඛ➃໬Ꮫ⏕࿨ᕤᏛ◊✲[aCYBER]ࢭࣥࢱ࣮㸧࡜ࡢ㛫࡛ࡢࢪࣙ࢖ࣥࢺ࣑࣮ࢸ࢕ࣥࢢࢆᐇ᪋ࡋࡲࡋࡓ㸬ᙜ᪥ࡣ㸪᪝ᡭ⛱ḟୡ௦ᇶ┙◊✲ᡤᡤ㛗ཬࡧ㸦ᅜ◊㸧⏘⥲◊ᮦᩱ࣭໬Ꮫ㡿ᇦ㒊㛛໭ᮏ኱㒊㛛㛗ࡽࡢᣵᣜࡢᚋ㸪୧◊✲ᶵ㛵࠿ࡽࡑࢀࡒ
ࢀ 4 ྡ㸦ྜィ 8 ྡ㸧ࡢ◊✲⤂௓࡜ウㄽࡀᐇ᪋ࡉࢀࡲࡋࡓ㸬ࡑࡢᚋࡣ㸪す᮲ᕷෆ࡛᠓ぶ఍ࢆᐇ᪋ࡋ࡚㸪௒ᚋࡢ୧◊✲ᶵ㛵ࡢࡉࡽ࡞ࡿ┦஫஺ὶࡀ㐍ࡵࡽࢀࡿࡇ࡜࡟࡞ࡾࡲࡋࡓ㸬

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఍ሙࡢᵝᏊᅜ◊ ⏘⥲◊ࠉ໭ᮏ኱㒊㛛㛗－ 45 －