PROSPECTUS 2021−2022

A Message From the Dean of Faculty of Medicine andGraduate School of Medicine, the University of Tokyo
The mission of a medical school is to develop human resources in the life and health sciences andpromote outstanding research in those fields. During its long history of more than 160 years, theUniversity of Tokyo School of Medicine has trained numerous medical researchers and health-care
professionals, many of whom have distinguished themselves in Japan and other countries. We haveconsistently produced leading medical research that has yielded exciting discoveries in biologicalphenomena, clarified the mechanisms of disease, and led to new technologies in medical diagnosis
and treatment. We in the Graduate School of Medicine aim to build on these achievements and tocontinue to play a leading role in promoting human welfare.
Several new projects have been implemented to strengthen the foundation of our research andclinical activities. The Molecular & Life Innovation Building is now open for promoting joint researchwith other faculties, including the Graduate School of Engineering and Graduate School of Science.
Clinical Research Center Building A has been completed and will function as a core clinical researchfacility. The South Research Building has been renovated and now features the Iron-Gate (Tetsu-Mon)
Clinical Lecture Hall. In basic research, the International Research Center for Neurointelligence (IRCN)
was started as part of the World Premier International Research Center Initiative (WPI). In support of
the Graduate School of Medicine, the IRCN has initiated research programs that will improve ourunderstanding of the origin of human intelligence. A new cryo-electron microscopy facility has been
opened as a shared facility that will allow researchers inside and outside the University to contributeto the field of structural biology in Japan.
As part of our ongoing improvements in graduate education, the University of Tokyo has
successfully implemented multiple doctoral degree programs as part of the World-leading Innovative &Smart Education (WISE) program. In particular, the World-leading Innovative Graduate Study Programfor Life Science and Technology (WINGS-LST) helps graduate students acquire advanced expertise andbroad perspectives in the life sciences. As the core of life sciences research at the University of Tokyo,
we will continue to promote cutting-edge research, accumulate clinical resources, and encourage
cooperation with other university faculties.
Many principal investigators in the Graduate School are internationally recognized leaders in thelife sciences and medicine, and all our laboratories provide young researchers and students with astate-of-the-art research environment. Moreover, we promote an atmosphere of inquiry in which
students and principal investigators actively discuss important and emerging issues in the life sciences
and medicine. This stimulating, interactive environment enables students to establish clear goals fortheir own original research. Finally, the advanced medical care provided at the University Hospitalenables clinical studies that utilize the hospital’s rich clinical data and bioresources and is an optimal
setting for research requiring big-data health-care analysis. Our fundamental mission is to develop newtechnologies for preventing, diagnosing, and treating disease, to apply these advances in clinicalsettings, and to train the medical researchers and practitioners who will establish the next generationof medicine.

Shigeo Okabe, MD,PhD
Dean, Faculty of Medicine and Graduate School of Medicine,
The University of Tokyo

HISTORY
1858

May
Nov.

Practitioners, trained in Dutch (European) medicine in Edo (Tokyo), laid out money to establish
the Shutojo (vaccination center) in Kanda Mitamagaike.
Shutojo was destroyed in a fire that had spread from Kanda Aioicho. Shutojo continued its
operations at other sites such as the residence of Ito Genboku.

1859

Sep.

Shutojo was reconstructed at Shitaya Izumibashi Dohri.

1860

Oct.

Shutojo became an official medical institution of the Shogunate Government.

1861

Oct.

Shutojo was renamed as Seiyo Igaku-Sho (Institute of Western Medicine) and offered coursesof Western Medicine in the fields of Education, Autopsy, and Vaccination.

1863

Feb.

Seiyo Igaku-Sho was renamed as Igaku-Sho (Institute of Medicine).

1868

Jul.

Igaku-Sho, affiliated with the Military Hospital which had been moved from Yokohama to Todo
residence in Shitaya, was renamed as Daibyoin (the Great Hospital).

1869

Feb.
Dec.

The Daibyoin was renamed as Igakko-Ken-Byoin (Medical School and Hospital).
Igakko-Ken-Byoin was renamed as Daigaku Toko (University East Building).

1871

Jul.

The Ministry of Education was established and Daigaku-Toko was renamed as Toko (East
Building).

1872

Aug.

A School System was established. Toko was renamed as Daiichi-Daigaku-Ku- Igakko (The First
University District Medical School).

1874

May

Daiichi-Daigaku-Ku-Igakko was renamed as Tokyo-Igakko (Tokyo Medical School).

1876

Nov.

Tokyo-Igakko was moved to Hongo.

1877

Apr.

Tokyo Igakko, affiliated with Tokyo-Kaisei School, was renamed as The University of Tokyo.
Tokyo Medical School was renamed as The University of Tokyo Faculty of Medicine.

1886

Mar.

The University of Tokyo was renamed as Imperial University, and The University of Tokyo
Faculty of Medicine was renamed as the Imperial University Medical College. A Graduate
School was established.

1897

Jun.

The Imperial University was renamed as Tokyo Imperial University.

1917

Aug.

Eiraku Hospital, affiliated with the Ministry of Education Medical Practice License Examination,
moved to Tokyo Imperial University and was renamed as Koishikawa Hospital affiliated with
Tokyo Imperial University Medical College.

1919

Apr.

A faculty system was established renaming Tokyo Imperial University Medical College as theFaculty of Medicine.

1931

Feb.

The first building of the Faculty of Medicine was constructed.

1936

Jan.
Nov.

The Brain Research Laboratory was built with funds donated by Mr. Hisasaburo Horikoshi.
The second building of the Faculty of Medicine (main building) was constructed.

1947

Oct.

Tokyo Imperial University was renamed as The University of Tokyo.

1950

Apr.

The Institute of Nursing was renamed as The University Nursing School.

1953

Apr.
Jul.

The School of Health Care and Nursing was founded.
The Graduate School was founded, and the Division of Medical Doctor Biological Science wasestablished. The Brain Research Laboratory became the Brain Research Institute of the Facultyof Medicine.

1956

Apr.

The Midwives School was established.

1958

Apr.
May

The Division of Pharmaceutical Sciences became an independent faculty.
The University of Tokyo Faculty of Medicine celebrated its centennial anniversary.

1961

Mar.

The Medical Library was built in commemoration of the centenary.

Apr.

The Institute of Medical Electronics was established.

Apr.

The Research Institute of Logopedics and Pediatrics was established. The School of Health Careand Nursing was reorganized as the School of Health Sciences. The Graduate School of The
University of Tokyo was reorganized and the Division of Medical Doctor Biological Science
became the Faculty of Medicine. The Health science Course was established in the Medical
Science Division.

1965

2

1966

Sep.

The third building of the Faculty of Medicine was constructed.

1971

Apr.

The Laboratory of Animal Experiments was established.

1973

Mar.

The Animal Center for Biomedical Research was constructed.

1983

Jan.

An annex of the third building of the Faculty of Medicine was constructed.

1985

Sep.

The office of International Academic Affairs was established.

1987

Apr.

Specialized courses were introduced to the Graduate School of Medicine.

1992

Apr.

The School of Health Sciences became the School of Health Science and Nursing. The Schoolof International Health was established in the Medical Science Division.
The Radiation Research Institute was established.

Jul.
1995

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, four divisions,Third Basic Medicine, Social Medicine, Third and Fourth Clinical Medicine, were replaced with
Pathology, Immunology and Microbiology, Social Medicine, Reproduction and Development,
and Aging Science and Surgery.

1996

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First Clinical Medicine, Health Science, and International Health, were replaced with Internal
Medicine, Health Science and Nursing, and International Health.

1997

Apr.

As a result of the shift to the chair system of the Graduate School of Medicine, three divisions,First and Second Basic Medicine, and Second Clinical Medicine, were replaced with Molecular
Cell Biology, Functional Biology, Radiology and Biomedical Engineering, and Neuroscience.
As a result of the above-mentioned reorganization, three institutes, the Institute of Brain
Research, the Institute of Medical Electronics, and the Institute of Logopedics and Phoniatrics
were made redundant.

		

1999

Apr.

The Master course of Medical Science was established in the Graduate School of Medicine.
This course accepts graduates of all faculties except those from Schools of Medicine, Dentistry,and Veterinary Medicine.

2000

Apr.

The International Research Center for Medical Education was established (A shared facility foreducation and research).

2001

Apr.

The University Branch Hospital was united with the University Hospital.

2002 Mar.
		

Nursing School and Midwives School was closed.
Experimental Building (First Stage) was constructed.

2003 Apr.
		The Center for Disease Biology and Integrative Medicine was established.
The Radiation Research Institute and the Laboratory of Animal Experiments were integrated
into the Center for Disease Biology and Integrative Medicine.

2004

Apr.

All the National Universities owned by the Japanese Government became National University
Corporations. and the University of Corporation.

2005

Mar.

Experimental Building (Second Stage) was constructed.

2007

Apr.

The School of Public Health was established. This school offers programs for Master of Public
Health.

2008

May.

The University of Tokyo Faculty of Medicine and the University of Tokyo Hospital celebrated
their 150th anniversary.

2010

Apr.

The School of Health Science and Nursing became the School of Integrated Health Sciences.

2011

Jan.

The Museum of Health and Medicine was established.

2012

Apr.

The Office for Research Ethics Support was established.

2013

Apr.

The International Research Center for Medical Education became a facility of the Graduate
School of Medicine.

2013

Oct.

The Life Sciences Core Facility was established.

2015

Apr.

The Office for Clinical Practice and Medical Education was established.

2017

Apr.

The Global Nursing Research Center was established.

2021

Apr.

The Center for Diversity in Medical Education and Research was established.

3As of May, 2021

Graduate School of Medicine					

P14Molecular Cell Biology
分子細胞生物学
Cell Biology
Cell Biology andAnatomy
Structural Biology
P14
Biochemistry andMolecular Biology*Collaborative Department

P17

P19

P21

Functional Biology
機能生物学
Physiology
P17
Pharmacology

Yasushi Okada
Masahide Kikkawa

Professor
Shigeo Okabe
Professor
Noboru Mizushima
Project Associate Professor Chieko Saito
Professor
Makoto Murakami
Cellular Signaling
Hiroki Kurihara
Physiological Chemistry and Metabolism Professor
Professor
Radostin Danev
Advanced Structural Biology

Clinical Genome Informatics / Lipid Science

Integrative Physiology
Cellular and Molecular Physiology
Neurophysiology
Cellular and Molecular Pharmacology
Systems Pharmacology

Professor
Kenichi Ohki
Professor
Masanori Matsuzaki
Professor
Masanobu Kano
Professor
Kenzo Hirose
Professor
Hiroki Ueda
Project Associate Professor Yoichi Minami

Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor

Tetsuo Ushiku
Kohei Miyazono
Daizo Koinuma
Masanori Hatakeyama
Kyoji Moriya
Hiroshi Takayanagi
Takeshi Nitta

Immunology

Microbiology
Infection Control and Prevention
Immunology*Collaborative Department

Tumor Pathology / Infection Pathology / Molecular Oncology

Microbiology

Radiology and Biomedical Engineering
生体物理医学
Diagnostic Radiology
Radiology
P21

Professor
Associate Professor
Associate Professor
Radiotherapy
Associate Professor
Nuclear Medicine
Professor
System Physiology
Associate Professor
Chemical Biology and Molecular Imaging Professor
Associate Professor

Biosystem Construction and Control
Integrative Genomics

4

Professor
Professor

Structural Cell Biology
Cellular Neurobiology
Molecular Biology

Pathology, Immunology and Microbiology
病因･病理学
Pathology and Diagnostic Pathology
Pathology
P19
Molecular Pathology

Biomedical
Engineering

P23

Dean Shigeo Okabe

Neuroscience
脳神経医学
Basic Neuroscience
P23
Integrative Medical
Neuroscience

Neuropathology
Neurochemistry
Neurobiology
Developmental Neuroscience
Cognitive Neuroscience
Systems Medical Neuroscience
Child Neuropsychiatry

Osamu Abe
Takeyuki Watadani
Hideomi Yamashita
Hidemasa Takao
Kiyoshi Miyagawa
Kimiko Yamamoto
Yasuteru Urano
Mako Kamiya

Professor
Katsutoshi Oda
Associate Professor Aya Ushiku

Professor
Professor

Takeshi Iwatsubo
Haruhiko Bito

Associate Professor Yukiko Kano

Clinical Neuroscience Neuropsychiatry
Neurology*Collaborative Department

P26

P28

Social Medicine
社会医学
Preventive Medicine
Occupational,
26
PEnvironmental
andPreventive Medicine Public HealthForensic Medicine,and Medical
Informatics andEconomics

Forensic Medicine*Collaborative Department

Cancer Health Services ResearchInternal Medicine
内科学
Medicine I
P28

Biomedical Informatics

Cardiovascular Medicine
Respiratory Medicine
Gastroenterology
Nephrology

Kiyoto Kasai
Seiichiro Jinde
Tatsushi Toda
Wataru Satake
Nobuhito Saito

Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Shumpei Ishikawa
Hiroto Katoh
Yasuki Kobayashi
Satoshi Toyokawa
Hirotaro Iwase
Yohsuke Makino
Kazuhiko Ohe
Kayo Waki

Professor
Professor

Issei Komuro
Takahide Nagase

Clinical Laboratory
Medicine andPathology

Professor
Associate Professor
Professor
Endocrinology
Associate Professor
Professor
Nutrition and Metabolism
Associate Professor
Professor
Hematology and Oncology
Professor
Allergy and Rheumatology
Professor
Infectious Diseases
Associate Professor
Stress Science and Psychosomatic Medicine Associate Professor
Professor
Clinical Laboratory Medicine
Associate Professor
Professor
Transfusion Medicine*Collaborative Department

Molecular Diabetology

Medicine II

P32

Neurosurgery
Biomedical Neural Dynamics

Professor
Associate Professor
Professor
Associate Professor
Professor

Reproductive, Development and Aging Sciences
生殖･発達･加齢医学
Reproductive Endocrinology
Obstetrics and
PGynecology
32
Gynecological Oncology

Pediatric Sciences

Associate Professor
Associate Professor
Associate Professor
Perinatal Medicine
Molecular Cellular Reproductive Medicine Professor
Associate Professor
Professor
Pediatrics
Associate Professor

Aging Sciences

Developmental Pediatrics
Pediatric Surgery
Pediatric Oncology
Geriatric Medicine*Collaborative Department

Aging Research
Health Policy for Children and Families

Professor

Masaomi Nangaku
Tetsuhiro Tanaka
Masaomi Nangaku
Noriko Makita
Toshimasa Yamauchi
Hironori Waki
Mineo Kurokawa
Keishi Fujio
Kyoji Moriya
Syu Okugawa
Kazuhiro Yoshiuchi
Yutaka Yatomi
Makoto Kurano
Hitoshi Okazaki

Takeshi Nagamatsu
Yasushi Hirota
Kaori Koga
Yutaka Osuga
Osamu Hiraike
Motohiro Kato
Yutaka Harita
Jun Fujishiro

Professor
Masahiro Akishita
Associate Professor Sumito Ogawa
Professor
Masahiro Akishita

5Surgical Sciences
外科学
P35

Surgery
P35

Thoracic Surgery
Cardiovascular Surgery
Gastrointestinal Surgery
Hepatobiliary Pancreatic Surgery

Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Jun Nakajima
Minoru Ono
Yasutaka Hirata
Yasuyuki Seto
Sachiyo Nomura
Kiyoshi Hasegawa
Junichi Arita
Haruki Kume

Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor

Soichiro Ishihara
Hiroaki Nozawa
Kazushige Kawai
Soichiro Ishihara
Katsuyuki Hoshina
Masahiko Tanabe
Shinichi Sato
Yoshihide Asano
Mutsumi Okazaki
Takuya Iida
Kazuto Hoshi
Hideto Saijo
Sakae Tanaka
Taku Saito
Yasushi Oshima
Makoto Aihara
Satoshi Kato
Megumi Honjo
Tatsuya Yamasoba
Kenji Kondo

Urology
Artificial Organ and Transplantation Division
Professor
Surgical Oncology

Vascular Surgery

Sensory and Motor
System Medicine

Breast and Endocrine Surgery
Dermatology
Plastic and Reconstructive Surgery
Oral and Maxillofacial Surgery
Orthopaedic Surgery

Ophthalmology

Vital Care Medicine

P42

Otolaryngology and Head and Neck
Surgery
Rehabilitation Medicine
Anesthesiology
Acute Medicine

Health Sciences and Nursing
健康科学･看護学
Health Sociology
Health Sciences
P42
Mental Health
Epidemiology and Preventive Health
Biostatistics
Health Education
Health Promotion Sciences
Biomedical Ethics

Preventive andAdministrative
Nursing6

Advanced Clinical Nursing
Nursing Administration
Family Nursing
Community Health Nursing
Public Health Nursing

Professor
Kanji Uchida
Associate Professor Kent Doi

Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Norito Kawakami
Daisuke Nishi
Yutaka Matsuyama
Koji Oba
Yutaka Matsuyama
Koji Oba

Professor
Associate Professor
Associate Professor
Associate Professor

Akira Akabayashi
Yoshiyuki Takimoto
Yukie Takemura
Yukie Takemura

Professor

Noriko Yamamoto-Mitani

Clinical Nursing

Gerontological Home Care and Longterm Care Nursing
Palliative Care Nursing
Midwifery and Women's Health
Psychiatric Nursing
Gerontological Nursing*Collaborative Department

Wound Care Management
Public Mental Health Policy

International Health
国際保健学International Social Global Health Policy
Community and Global Health46
PMedicine
Human Genetics
International
P46 Biomedical Sciences Developmental Medical Sciences
Human Ecology
Biomedical Chemistry

P49

Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor

Noriko Yamamoto-Mitani
Ayumi Igarashi
Noriko Yamamoto-Mitani
Megumi Haruna
Norito Kawakami
Yuki Miyamoto
Hiromi Sanada
Gojiro Nakagami
Hiromi Sanada

Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor

Masahiro Hashizume
Masamine Jimba
Akihiro Fujimoto
Teruyuki Tanaka
Masahiro Umezaki
Shoko Konishi
Tomoyoshi Nozaki
Yoh-ichi Watanabe

School of Public Health
公共健康医学
Biostatistics
Epidemiology and
49 Sciences
PHealthSocial and Preventive Epidemiology

Behavioral Health
Sciences

Professor
Professor
Clonical Epidemiology and Health EconomicsProfessor
Professor
Health Communication
Associate Professor
Professor
Mental Health
Associate Professor

Health Sociology and Health Education
Professor
Health and Social Behavior
Health Promotion Sciences
Professor
Biomedical Ethics

Health Services
Sciences

Health Policy
Healthcare Informatics
Clinical Information Engineering
Forensic Medicine and Medical Law*Collaborative Department

Global Environmental HealthPublic Health Science

Laboratoryof Molecular Biomedicine for Pathogenesis
センター長
狩野方伸

P53 P53Laboratory of Structural Physiology

Laboratory of Biomedical Equipment and Biomaterial
Laboratory of Clinical Biotechnology
Laboratory of Environmental and Metabolic Health
Sciences
Laboratory of Animal Resources
Laboratory of Molecular Radiology
Biomedical Infomatics

Hideki Hashimoto

Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Associate Professor

Center for Disease Biology and Integrative Medicine
疾患生命工学センター

Yutaka Matsuyama
Satoshi Sasaki
Hideo Yasunaga
Takahiro Kiuchi
Tsuyoshi Okuhara
Norito Kawakami
Daisuke Nishi

Akira Akabayashi
Yoshiyuki Takimoto
Yasuki Kobayashi
Satoshi Toyokawa
Kazuhiko Ohe
Hiroshi Oyama
Hirotaro Iwase
Yohsuke Makino
Yoonhee Kim

Director Masanobu Kano

Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor

Toru Miyazaki
Satoko Arai
Haruo Kasai
Taichi Ito
Kanako Harada
Hironori Hojo
Makoto Murakami
Seiichiroh Ohsako
Atsu Aiba
Hidetoshi Kassai
Kiyoshi Miyagawa
Noriko Hosoya
Takeshi Imai

7

The International Research Center for Medical Education Director Tatsuya Yamasoba
医学教育国際研究センター
Department
センター長
山岨達也 of Medical Education Studies

P56 P56

Professor

Masato Eto

Department of International Cooperation for Medical Education

グローバルナーシング
Global Nursing Research Center
リサーチセンター
Divisionof Care Innovation
センター長
真田弘美

P57 P57
Division of Nursing System

Director Hiromi Sanada
Professor
Associate Professor
Project Associate Professor
Project Associate Professor
Project Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Hiromi Sanada
Gojiro Nakagami
Takeo Minematsu
Nao Tamai
Ryoko Murayama
Noriko Yamamoto-Mitani
Megumi Haruna
Yukie Takemura
Yuki Miyamoto
Ayumi Igarashi

医学のダイバーシティ
Director Kiyoto Kasai
Center for Diversity in Medical Education and Research
教育研究センター
Centerfor Diversity in Medical Education and Research
センター長
Associate Professor
Yoshihiro Satomura
笠井清登

P58 P58
Institution
教育研究関連施設
The Office of International Academic Affairs

P59

P59 Medical Scientist Training Program

Office for Research Ethics Support
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Medical LibraryMuseum of Health and Medicine

Head
Head
Director
Head
Head
Head
Head

Shinichi Sato
Kenzo Hirose
Masaomi Nangaku
Yoshihiro Kita
Masato Eto
Hideo Yasunaga
Kazuhiko Ohe

Endowed Department
Department of Bone & Cartilage Regenerative Medicine

Project Associate Professor

Fumiko Yano

Department of Immunotherapeutics

Project Professor

Kazuhiro Kakimi

Department of Advanced Clinical Science and Therapeutics Project Associate Professor
Computational Diagnostic Radiology and Preventive
Medicine

Mutsuo Harada

Project Professor

Naoto Hayashi

Project Associate Professor

Takeharu Yoshikawa

Clinical Trial Data Management
Ubiquitous Preventive Medicine

Project Associate Professor

Yuichi Ikeda

Science for Joint reconstruction

Project Professor

Toru Moro

Department of Therapeutic Strategy for Heart Failure

Project Associate Professor

Masaru Hatano

Project Associate Professor

Haruhiro Toko

Project Professor

Ko Matsudaira

Project Associate Professor

Hiroyuki Oka

Department of Molecular Structure and Dynamics
Department of Advanced Translational Research andMedicine in Management of Pulmonary Hypertension
Department of medical research and management formusculoskeletal pain
Department of Osteoimmunology

Project Associate Professor

Kazuo Okamoto

Health Economy and Society Policy
Department of medical and pharmaceutical community
healthcare
Department of Molecular Neurology

Project Professor

Tomoyuki Takura

Project Professor

Hirohisa Imai

Project Professor

Shoji Tsuji

Project Associate Professor

Jun Mitsui

Project Professor

Daisuke Koide

Department of Biostatistics and Bioinformatics

8

Laboratory for Advanced Research on Pathophysiology ofMetabolic Diseases
Department of Home Care Medicine
Department of Advanced Cardiology

Project Associate Professor

Miki Iwabu

Project Associate Professor

Takashi Yamanaka

Project Associate Professor

Katsuhito Fujiu

Artificial Intelligence in Healthcare

Project Associate Professor

Yoshimasa Kawazoe

Comprehensive radiation oncology

Project Professor

Keiichi Nakagawa

Research on Cell Therapy of Regenerative Medicine

Project Associate Professor

Chang Dehua

Department of Lipidomics

Project Professor

Yoshiya Oda

Advanced Nursing Technology

Project Associate Professor Ryoko Murayama

Social Cooperation Program

Department of Health Services Research

Project Associate Professor Taisuke Jo

Skincare Science

Project Associate Professor Takeo Minematsu

Department of Healthcare Quality Assessment

Project Professor

Hiroaki Miyata

Project Associate Professor Hiraku Kumamaru
Imaging Nursing Science

Project Associate Professor Nao Tamai

Department of Innovative Dementia Prevention
Department of Functional Genomics and Immunological
Diseases
Department of Prevention of Diabetes andLifestyle-Related Diseases
Department of Next-Generation Pathology Information
Networking
Chronic kidney disease pathophysiology

Project Associate Professor Tadafumi Hashimoto

Project Associate Professor Satoko Yamaguchi

Tissue stem cell / life dentistry
Department of Next Generation Locomotive Imaging System

Project Associate Professor Yuki Taniguchi

Project Associate Professor Tomohisa Okamura

Project Professor

Takeshi Sasaki

Project Professor

Reiko Inagi

Project Professor

Makoto Komura

Department of Preventive Medicine for Locomotive Organ Project Professor

Noriko Yoshimura

Department of Eat-loss Medicine

Project Associate Professor Kazumichi Yonenaga

Next-Generation Precision Medicine Development Laboratory

Project Associate Professor Hidenori Kage

Department of Pain & Palliative Medical Sciences

Project Associate Professor Maiko Hasegawa

Faculty of Medicine
School of Medicine

School of
Integrated Health
Sciences

Dean Shigeo Okabe
Cell Biology and Anatomy / Biochemistry and Molecular Biology / Physiology /Pharmacology / Pathology / Microbiology / Immunology / Radiology /Biomedical Engineering / Basic Neuroscience / Integrative Medical Neuroscience /Clinical Neuroscience / Occupational, Environmental and Preventive Medicine /Medical Principles and Medical Ethics / Forensic Medicine, and Medical Informatics
and Economics / Medicine I / Medicine II / Clinincal Laboratory Medicine andPathology / Obstetrics and Gynecology / Pediatric Science /Aging Science / Sugery /Sensory and Motor System Medicine / Vital Care Medicine
Family Nursing / Community Health Nursing / Fundamental Nursing /Gerontological Nursing / Midwifery and Women's Health / Adult Health and Nursing /Mental Health and Nursing / Health Sociology /Health Administration /Epidemiology and Biostatistics / Human Ecology /Biochemistry and Nutrition /Maternal and Child Health9University Hospital					Director Yasuyuki Seto

Clinical Division
診療科
Department ofInternal Medicine

Department ofSurgery

Department of
Sensory andMotor System
Medicine

10

General Medicine
Cardiovascular Medicine
Respiratory Medicine
Gastroenterology
Nephrology and Endocrinology

Professor
Professor
Professor

Professor
Associate Professor
Associate Professor
Diabetes and Metabolic Diseases
Professor
Associate Professor
Hematology and Oncology
Professor
Allergy and Rheumatology
Professor
Infectious Diseases
Professor
Associate Professor
Neurology
Professor
Associate Professor
Geriatric Medicine
Professor
Associate Professor
Psychosomatic Medicine
Associate Professor
General Surgery
Professor
Stomach and Esophageal Surgery
Professor
Associate Professor
Professor
Colon and Rectal Surgery
Associate Professor
Associate Professor
Hepatobiliary Pancreatic Surgery
Professor
Associate Professor
Vascular Surgery
Professor
Associate Professor
Breast and Endocrine Surgery
Associate Professor
Artificial Organ and Transplantation Surgery Professor
Associate Professor
Cardiovascular Surgery
Professor
Associate Professor
Thoracic Surgery
Professor
Neurosurgery
Professor
Anesthesiology and Pain Relief Center
Professor
Urology and Andrology
Professor
Gynecologic Surgery
Professor
Associate Professor
Dermatology
Professor
Associate Professor
Ophthalmology
Professor
Associate Professor
Associate Professor
Orthopaedic Surgery and Spinal Surgery
Professor
Associate Professor
Associate Professor
Otolaryngology and Head and Neck Surgery Professor
Associate Professor
Rehabilitation Medicine
Associate Professor
Plastic, Reconstructive and Aesthetic Surgery Professor
Associate Professor
Oral-Maxillofacial Surgery and Orthodontics Professor
Associate Professor

Masahiro Akishita
Issei Komuro
Takahide Nagase
Masaomi Nangaku
Tetsuhiro Tanaka
Noriko Makita
Toshimasa Yamauchi
Hironori Waki
Mineo Kurokawa
Keishi Fujio
Kyoji Moriya
Syu Okugawa
Tatsushi Toda
Wataru Satake
Masahiro Akishita
Sumito Ogawa
Kazuhiro Yoshiuchi
Soichiro Ishihara
Yasuyuki Seto
Sachiyo Nomura
Soichiro Ishihara
Hiroaki Nozawa
Kazushige Kawai
Kiyoshi Hasegawa
Junichi Arita
Soichiro Ishihara
Katsuyuki Hoshina
Masahiko Tanabe
Kiyoshi Hasegawa
Junichi Arita
Minoru Ono
Yasutaka Hirata
Jun Nakajima
Nobuhito Saito
Kanji Uchida
Haruki Kume
Yutaka Osuga
Yasushi Hirota
Shinichi Sato
Yoshihide Asano
Makoto Aihara
Satoshi Kato
Megumi Honjo
Sakae Tanaka
Taku Saito
Yasushi Oshima
Tatsuya Yamasoba
Kenji Kondo
Toru Ogata
Mutsumi Okazaki
Takuya Iida
Kazuto Hoshi
Hideto Saijo

Department ofPediatrics, Perinatal and
Women's Medicine

Pediatrics

Department of
Neuropsychiatry

Neuropsychiatry

Department of Radiology

Radiology

Acute Medicine

Acute Medicine

Pediatric Surgery
Obstetrics and Gynecology

Professor
Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Associate Professor

Motohiro Kato
Yutaka Harita
Jun Fujishiro
Yutaka Osuga
Kaori Koga
Takeshi Nagamatsu
Osamu Hiraike
Kiyoto Kasai
Seiichiro Jinde
Shuntaro Ando
Osamu Abe
Hideomi Yamashita
Hidemasa Takao
Takeyuki Watadani
Kent Doi

Central Clinical Facilities
Pharmaceutical Department
Nursing Department
Administration Department
Legal and Compliance Office
Department of Clinical Laboratory
Surgical Center
Radiology Center
Department of Blood Transfusion
Perinatal Center
Rehabilitation Center
Department of Medical Engineering
Central Supply Service
Intensive Care Unit
Pathology
Department of Corneal Transplantation
Department of Cell Therapy and Transplantation Medicine
Department of Endoscopy and Endoscopic Surgery
Department of Hemodialysis and Apheresis
Infection Control and Prevention Service
Department of Healthcare Information Management
University Hospital Medical Information Network Center
Organ Transplantation Center
Labor Safety and Health Management Office
Staff Wellness Consulting RoomChild Psychiatry
Tissue Bank
Center for Epidemiology and Preventive Medicine
Center for International Preventive Medicine
Center for Liaison and Public Relations
Datebase Center of the National University Hospitals
Department of Chemotherapy
Department of Medical Record Management
Critical Care and Emergency Medical Center/Emergency Room
Department of Pain and Palliative Medicine
Children's Medical Center
Department of Disaster Medical Management
International Medical Center

Professor

Hiroshi Suzuki

Professor
Professor
Professor
Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Professor
Professor
Professor
Associate Professor
Professor
Professor
Professor
Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Sakae Tanaka
Yutaka Yatomi
Kazuhiko Fukatsu
Osamu Abe
Hitoshi Okazaki
Yutaka Osuga
Miyuki Harada
Toru Ogata
Kent Doi
Kazuhiko Fukatsu
Kent Doi
Tetsuo Ushiku
Makoto Aihara
Mineo Kurokawa
Yosuke Nakai
Masaomi Nangaku
Kyoji Moriya
Kazuhiko Ohe
Takahiro Kiuchi
Tsuyoshi Okuhara
Jun Nakajima
Masaaki Sato
Tomotaka Yamamoto
Kiyoto Kasai
Yukiko Kano
Sumihito Tamura
Nobutake Yamamichi

Professor

Yutaka Osuga

Professor
Associate Professor
Professor
Associate Professor
Associate Professor
Professor
Associate Professor
Associate Professor

Kiyoshi Miyagawa
Hironori Ishigami
Kazuhiko Ohe
Kent Doi
Masahiko Sumitani
Motohiro Kato
Kent Doi
Sumihito Tamura

11

Clinical Nutrition Center
Department of Pediatric and Neonatal Intensive Care
Department of Clinical Genomics
BioResource Center

Professor
Associate Professor
Professor
Professor
Professor

Kazuhiko Fukatsu
Naoto Kubota
Naoto Takahashi
Katsutoshi Oda
Tetsuo Ushiku

Professor
Associate Professor
Professor
Professor
Professor
Professor
Professor
Professor

Takashi Moritoyo
Tatsuya Maruyama
Yutaka Osuga
Kazuto Hoshi
Minoru Ono
Issei Komuro
Yutaka Osuga
Takeshi Iwatsubo

Clinical Research Division
Clinical Research Promotion Center
22nd Century Medical and Research Center
Department of Tissue Engineering
Cooperative Unit of Medicine and Engineering Research
Translational Research Center
Genomic Research Support Center
Unit for Early and Exploratory Clinical Development

Organization of Clinical Management Support
Department of Personnel Administration and Human Resource Management Professor
Medical Specialists Training Center
Medical Support Center
Professor
Department of Performance Monitoring and Risk Management
Professor
Office of Performance Monitoring
Associate Professor
Medical Safety Management Center
Associate Professor
Infection Control Center
Professor
Department of Highly Advanced Novel Medical Technologies Evaluation Professor
Department of Unapproved New Drugs and Medical Devices Evaluation Professor
Department of Education and Staff Development
Professor
General Education Center
Professor
Hospitality Center
Department of Hospital Planning and Management
Professor
Department of Research Support
Professor
Department of Clinical Research Governance
Project Professor

Yutaka Yatomi
Sakae Tanaka
Sakae Tanaka
Tomotaka Yamamoto
Tomotaka Yamamoto
Kyoji Moriya
Jun Nakajima
Kanji Uchida
Tatsuya Yamasoba
Masato Eto
Jun Nakajima
Yutaka Osuga
Junji Moriya

Organization of Clinical Management
Inpatient Services Administration
Admission and Discharge Center
Cancer Board
Outpatient Services Administration
Central Clinical Services Administration
Advanced Medical Center for Heart Failure
Vascular Board
Perioperative Assessment Center
Swallowing Center
Epilepsy Center
Immune-Mediated Diseases Therapy Center
SSc Center
Osteoporosis Center
Center for Female Pelvic Medicine and Reconstructive Surgery
Spine Center
Hip Fracture Board
Palliative Care Consulation Team
Nutrition Support Team
Division of patient supportDivision of patient support services
Medical Community Network and Discharge Supporting Center
Cancer Resource Center
Patient Relations and Clinical Ethics Center

12

Professor

Haruki Kume

Professor
Professor
Associate Professor
Project Associate Professor
Associate Professor
Professor
Associate Professor

Kiyoshi Miyagawa
Kiyoshi Miyagawa
Masahiko Sumitani
Masaru Hatano
Katsuyuk Hoshina
Kanji Uchida
Rumi Ueha

Associate Professor
Associate Professor
Associate Professor
Professor
Associate Professor

Hiroko Kanda
Yoshihide Asano
Taku Saito
Yutaka Osuga
Yasushi Oshima

Associate Professor
Professor
Professor
Associate Professor
Associate Professor
Associate Professor

Masahiko Sumitani
Kazuhiko Fukatsu
Yutaka Osuga
Masahiko Sumitani
Sachiyo Nomura
Yoshiyuki Takimoto

Faculty of Medicine
Graduate School of
Medicine
The University of Tokyo

Graduate School of Medicine

Molecular Cell Biology.............................................. 14
Functional Biology..................................................... 17
Pathology, Immunology and Microbiology.................. 19
Radiology and Biomedical Engineering....................... 21
Neuroscience ..........................................................23
Social Medicine........................................................26
Internal Medicine . ...................................................28
Reproductive, Developmental and Aging Sciences . ....32
Surgical Sciences .....................................................35
Health Sciences and Nursing ....................................42
International Health .................................................46
School of Public Health ............................................49
Center for Disease Biology and Integrative Medicine...53
The International Research Center for
Medical Education.............................................56
Global Nursing Research Center................................57
Center for Diversity in Medical Education andResearch........................................................... 58
Institution

59

The Office of International Academic Affairs
Medical Scientist Training Program
Office for Human Research Studies
Life Sciences Core Facility
The Office for Clinical Practice and Medical Education
Medical LibraryMuseum of Health and Medicine

13

A
G
C
T
Molecular Cell Biology

Cell Biology
Our goal to deepen the physical understanding of living cells. Our main
approach is observing the dynamics of the individual molecules in living cells.
For this end, we are also working on the development of the underlying
technologies, including fluorescent and other probes, microscope and otherequipment, analytical techniques using machine learning or physical theories.
Development and application of super-resolution and/or single-molecule
imaging● Development of fluorescent probes to visualize cellular states● Application of machine learning to analyze microscope images● Single molecule measurement of molecular motors under crowding
environments in living cells.
● Measurement of non-equilibrium fluctuation in living cells and explorationof its physiological meanings.
●

Single molecule imaging of kinesin molecules inliving cell.

Structural Biology
Kikkawa lab is interested in eukaryotic flagella/cilia, which works as apropeller and a sensor of cells. We study regulatory mechanisms of flagella/cilia beating by combining cryo-electron microscopy, optical microscopy withhigh-speed camera, cell biology, and genetics. We also provide cryo-electron
microscopes as shared facilities.
Our current focuses are:
● How cilia/flagella are assembled.
● Molecular mechanisms of flagella and axonemal
dyneins.
● Provide cryo-electron microscopy as shared facility

Cryo-electron microscopies installed in the University of Tokyo.
From left to right: Titan Krios G3i (upper left), Talos Arctica (upper right),
Aquilos (FIB-SEM,lower left), JEOL JEM-F200 (lower right).

14

http://structure.m.u-tokyo.ac.jp/

Structural Cell Biology

http://cb.m.u-tokyo.ac.jp/

Our laboratory aims to study the function of microtubule-based molecularmotors, kinesin superfamily proteins (KIFs). We have previously identified 45
KIF genes from human and mouse genomes. According to mouse molecular
genetics and structural biological analyses, we have identified their functional
relevance in higher brain function, brain wiring, left-right determination,
tumor suppressing pathway, metabolic diseases, and so on. However, there
still exist multiple interesting questions in this field, which we aim to solve by
multidisciplinary and comprehensive approaches.

The neuronal cytoskeleton and its associated organelles（From Nature Milestones 2008）

Cellular Neurobiology
The Laboratory of Cellular Neurobiology is interested in understanding themolecular mechanisms regulating synapse formation and maintenance,
which are essential in proper function of neural circuits in the brain. The
laboratory is using optical imaging of synaptic molecules in live neurons, in
combination with molecular biological approaches to modify neuronal
functions.
Molecular architecture of the postsynaptic density
Molecular mechanisms of activity-dependent synapse remodeling● Regulation of synapse functions by glial cells● Regulation of synapse formation and maintenance in vivo
● Synapse dysfunction in psychiatric diseases●●

Quantitative fluorescence imaging of cultured
hippocampal neurons (green: postsynaptic protein andcalibrated fluorescent microspheres, red: presynaptic
protein, blue: microtubule-associated protein)

Molecular Biology

https://molbiolut.jp/en/

Our laboratory has been doing trans-disciplinary studies
primarily on autophagy, an intracellular degradation
system, and trying to elucidate the mechanisms andbiological and pathophysiological functions of autophagy.
Molecular mechanism of autophagy (membrane
dynamism, lysosomal degradation, selectivity, etc.)● Physiological and pathophysiological roles of
autophagy● Development of new methods for monitoring andmodulating autophagy● Autophagy-independent mechanisms of intracellulardegradation●

15

Cellular Signaling

https://lmmhs.m.u-tokyo.ac.jp

Lipids serve as the largest energy source, cell membrane components,
and bioactive mediators. Lipids are major environmental substances
supplied as nutrients and spatiotemporally regulate a variety of
biological responses in response to given microenvironmental cues
within tissues. Our research focuses on the regulation of biologicalnetworks driven by lipids and their metabolites. By taking advantagesof an array of gene-manipulated mice for lipid-metabolizing enzymes
and receptors, we aim to clarify novel lipid-orchestrated mechanisms
underlying various diseases such as metabolic and immune
disorders. Knowledges obtained from these approaches will betranslated to humans toward discovery of new biomarkers or
druggable targets.

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;хϳϬŐĞŶĞƐ䠅.QRFNRXWPLFH/LSLGRPLFV'LVHDVHV8QGHUVWDQGLQJRIVSDWLRWHPSRUDOOLSLGIORZVLQKHDOWKDQGGLVHDVHV'LVFRYHU\RIQRYHOOLSLGSDWKZD\VWKDWDUHOLQNHGWRELRORJLFDOSURFHVVHVPhysiological Chemistry and Metabolism

http://bio.m.u-tokyo.ac.jp/

We are investigating cellular behavior and signaling mechanisms
underlying cell fate determination, morphogenesis andorganogenesis in embryonic development.
Mechanisms of neural crest fate determination andcraniofacial morphogenesis● Mechanisms of cardiac development● Mechanisms of angiogenesis●

Understanding morphogenesis and organogenesis
based on collective cell movement

Advanced Structural Biology
Our main interest is development of new methods and improvement ofexisting techniques for structure determination by cryo-electron microscopy(cryo-EM). Simultaneously, we are using state-of-the-art cryo-EM to study the
structures of "difficult" samples, such as membrane proteins, small (< 100kDa) molecules, heterogeneous samples and intact cellular volumes.
Cryo-EM is already past the tipping point and is being widely accepted andappreciated as a capable structural biology method. There are several areas
where further progress is expected and/or already ongoing. Instrumentation,
sample preparation, automation, deep learning and streamlining of theresearch process are of great interest to us and we are trying to contribute inthese directions.

The structures of G-protein coupled receptors (upper) andhemoglobin (lower) solved by cryo-electron microscopy

16

http://danevlab.m.u-tokyo.ac.jp/

Functional Biology

Integrative Physiology
The cerebral cortex acquires complicated response selectivity by receiving
and processing information from the outside of the world. However, it is still
unknown what kind of neural circuit actually is involved this information
processing. In recent years, progress of imaging technology (two-photon
excitation method) has made it possible to simultaneously measure theactivity of thousands of nerve cells from a living animal (Ohki et al., 2005,
2006). In addition to that, various technologies for studying neural circuits
are being developed one after another and research on neuroscience isentering a transition era. In our laboratory, by using these latest methods,
we are trying to find out how the neural circuits of mammalian visual cortex
process information.

https://physiol1.m.u-tokyo.ac.jp/ern24596/
We clarify the functional unitary circuit, its
operation principle and formation principleof the cortex using two-photon imaging
and optogenetics.

Two-photon imaging

Unitary circuit
Functional Organization

Optogenetics

Elucidation of functional unitary circuitin the cortex
Methods: two-photon microscopy
with single-cell resolutionPeters & Payne 1993

Formation Principle
Interplay between innate factors
And activity-dependent processes
Methods: Genetic manipulations andOptogenetics

Operation Principle
Information representation and decoding
Methods:9Fast two-photon volume imaging

Functional organization in the visual cortex
Development of neural circuits in the visual cortex● Information representation in the visual cortex● Roles of each cell-type in the processing of visual information●●

Cellular and Molecular Physiology

http://plaza.umin.ac.jp/~Matsuzaki-Lab/

Our laboratory studies the neural circuits in the frontal cortex, which emerge
movement and thought. Applying two-photon imaging, optogenetics, andelectrophysiology to behaving mice and marmosets, we measure andmanipulate the activities of multiple neurons and analyze their dynamics.
Neural circuits for motor learning and motor execution.
Neural circuits for decision making.
● Neural circuits for brain-machine-interface.
● Development of novel fluorescent microscopy system.
●●

Two-photon image ofthe mouse motor cortical neurons

17Neurophysiology
The synapse is a key structure essential for brain
function. We study how synapses work and undergochanges during postnatal development, learning andmemory by recording neural activity in real time. We use
various methodologies including electrophysiology,
molecular biology, and optical imaging of functional
molecules.
Postnatal development of synaptic function andorganization in the cerebellum● Retrograde synaptic modulation mediated byendogenous cannabinoids● Synaptic integration in intact animals● Synaptic plasticity and motor learning in the cerebellum

http://plaza.umin.ac.jp/˜neurophy/〜P3
Purkinje cell

Parallelﬁbers

P12〜P17

P8〜P11

P4〜P7

Strengthened

Translocate

Translocate

Maintained

EliminatedEliminatedClimbing ﬁbers

Synapse formation
Multi-innervation

P18〜

Parallel ﬁber dependent

Functional
diﬀerentiation

Synapse elimination
Early phase

Late phase

Monoinnervation

P9〜 Climbing ﬁber translocation to dendrite●

Postnatal development of climbing ﬁber to Purkinje cell synapses

Postnatal development of cerebellar climbing fiber to Purkinje cell synapses

Cellular and Molecular Pharmacology

http://www.pharmacol.m.u-tokyo.ac.jp/

We aim to elucidate the regulation mechanism ofphysiological functions mainly on the central nervous
system by making full use of our unique fluorescentimaging technique. Currently, we are developing uniquemolecular tag, super-resolution imaging, and calcium
imaging technique by fusing cutting-edge methods suchas chemical biology, organic chemistry, molecular biology,
and optics. By applying these novel imaging techniques toneuroscience research, we are promoting research on themechanism of synaptic transmission in the central
nervous system, mainly focusing on the molecularmechanism underlying releasing neurotransmitters in thepresynaptic terminal.

Systems Pharmacology
We are aiming at understanding of how multi-stability
and homeo-dynamics in sleep-wake systems, as amodel system, can be achieved through negative
feedback regulation of membrane potential in neurons,
and neural circuit structures. Also, we are establishinga high-throughput production platform of geneticallyengineered mice to facilitate a quantitative analysis andperturbation at the organismal level, and paving theway for the basic research by associating with humangenome analysis obtained from clinical studies.
Elucidation of the regulatory principle of sleep-wakerhythm● High-throughput production platform of geneticallyengineered mice
● Application of human genome analysis from clinicalstudies to basic research●

18

OrganismͲlevelSystemsBiologythrough
UnderstandingofSleepͲawakeCycle
Elucidationoftheregulatory
principleofsleepͲwakerhythmHighͲthroughputplatformofgeneticallyengineeredmice

Applicationofclinicalstudies
tobasicresearch

AdvancedGenome&DevelopmentalEngineering

SleepͲawakecyclesinCNS“100%ESmice”“Quantitative”or“Qualitative”Oscillation?

HowSleepͲwakeHistoryis
RecordedinCNS?

EstablishmentofF0Phenotyping
throughNonͲinvasiveAnalysis

VerificationoftheIdentifiedDiseaseͲ
relatedGenesfromHumanGenome
AnalysisbyModelAnimals

TowardmultiͲscaleunderstandingofbiologicalsystems,weareplanningmultiͲscaleresearch
activitiesbasedondifferentbackgroundssuchasphysics,chemistry,informatics,engineering,
andmedicine,andintercommunicatingbetweenfoundationsandclinics.

Pathology, Immunology and Microbiology

Pathology and Diagnostic Pathology

http://pathol.umin.ac.jp/index_e.htm

Our laboratory performs a wide range of pathology researchusing morphology-based methods along with cutting-edge
technologies, which will lead to earlier diagnosis, more precise
prognosis, and tailored therapy. We are developing nextgeneration diagnostic system and platform with integration of
genomic information and advanced decision-support tools
using artificial intelligence to deliver more accurate diagnosis
and tailored treatment.
●

●
●
●
●

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Gastrointestinal cancers and others
Primitive phenotypic transformation of cancer cell
Inflammatory conditions of gastrointestinal tract
Neurodegenerative diseases
Others<RONVDFOLNH

Next generation Diagnostic Pathology●●●●

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Application of machine learning technology
Cancer gene panel testing
3D pathology
Telepathology and Digital Pathology

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Molecular Pathology
We study signaling mechanisms of the TGF-β family
proteins, and elucidate how they regulate progression ofcancers. Mechanisms of regulation of TGF-β-Smad target
genes will be studied by genome-wide approaches.
Based on these findings, we will develop new strategies
for the treatment of cancer.
Dynamic changes in the transcriptional machinery
regulated by TGF-b● Roes of TGF-b in epithelial-mesenchymal transition(EMT)● Roles of tumor microenvironment - approach byorthotopic transplantation models● Analysis of cancer metastasis by tissue-clearing
methods●+HSDWRLG

Pathology Research●●)HWDOJXWOLNH

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19

Microbiology

http://www.microbiol.m.u-tokyo.ac.jp/

Our major objective is to elucidate molecular mechanisms
underlying development of gastric carcinoma triggered by
infection with Helicobacter pylori. Based on the results obtained
from these studies, we are also developing new strategies forprevention and treatment of infection/inflammation-associatedcancers, which account for ~ 50% of entire human malignancies.
Structural biological analysis of H. pylori oncoprotein CagA
Intracellular signaling pathways targeted by CagA
● Mouse genetic studies on gastric carcinogenesis● Host genetic factors determining gastric cancer susceptibility● Molecular mechanisms linking inflammation and cancer●●

H. pylori - gastric epithelial cell interaction

Infection Control and Prevention
We are engaged in education of medical staff as well as in daily clinical activities
on the prevention of healthcare-associated infection (HAI). Research activities on
the pathogenesis of infection with hepatitis viruses and HIV, in particular, on themechanism of hepatocarcinogenesis in HCV infection are also our mission.
Development of preemptive strategies for the control of healthcare-associatedinfection● Development of new methods in infection control and treatment of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV infection● Pathogenesis of progression of HIV infection● Molecular pathogenesis of the mitochondrial disturbances in viral infections● Molecular pathogenesis of hepatitis B viral infection● Host defences to microorganisms● Molecular analysis of innate immunity in microorganism infection● New detection method and pathogenesis of opportunistic cytomegaloviral infection● Mechanism of multi-drug resistant microorganisms● Molecular epidemiology of Clostridium difficile●

Immunology
We aim to comprehensively understand immune responses byanalyzing molecular mechanisms of the development of immune
cells and the regulation of innate and adaptive immune systems,
and to provide novel strategies for the treatment of immune
diseases. We focus on the molecules and immune cells that
contribute to autoimmune diseases, employing geneticallymodified mice to address their physiological significance in vivo.
Animal models for studying immune cells by genome
engineering technology● Molecular mechanisms of immune cell development● Role of immune tissue microenvironment in immune cell
regulation● Mechanisms and pathogenesis of autoimmune diseases● Regulation of bone metabolism by the immune system● Regulation of immune cells in bone microenvironment●

20

Infection control team rounds

http://www.immunol.m.u-tokyo.ac.jp/english
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Radiology and Biomedical Engineering

Radiology

http://www.ut-radiology.umin.jp/

We have been performing a variety of research studies in biomedical imaging
and analysis, computer-assisted diagnosis (CAD) and radiation therapy.
●

Diagnostic Radiology
●
●
●

●

Radiation Oncology●●●

MRI analysis of brain morphology, diffusion, function and network
Development and application of CAD systems
Simulation of interventional radiology procedures using 3D printing
Stereotactic irradiation by gamma knife, synergy system and intensity
modulated radiotherapy (IMRT)Clinical and biological studies for the reduction of radiation-induced damage

Nuclear Medicine●●

Functional imaging using radioisotope-labeled tracer technology
Imaging of brain metabolism and aggregated proteins using PET
Representative images analyzed with computerassisted technology

System Physiology
We study biomechanics dealing with mechanical phenomena in thehuman body, especially focusing on cellular sensing and mechanisms
underlying the responses to mechanical stimuli. The main theme of
our work is to elucidate how vascular endothelial cells sense
hemodynamic forces (i.e., shear stress and stretch) generated byblood flow and blood pressure. This would be of benefit not only forunderstanding the blood flow-mediated regulation of vascularfunctions, angiogenesis, and vascular remodeling but also for the
elucidation of clinically important problems, such as hypertension,
thrombosis, and the developments of atherosclerosis and cerebral
aneurysms.

http://square.umin.ac.jp/bme/research_Eng.html
Hemodynamic forcePhysiological conditions(Laminar flow)

Pathogenetic conditions(Disturbed flow)

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Mechanosensing and mechanotransduction● Hemodynamic force-induced cellular responses● Hemodynamic force-mediated gene regulation● Disturbed flow-induced vascular diseases

147
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Signal transduction

Homeostatis of
Circulatory system

Vascular diseases
Hypertension Thrombosis
Aneurysm Atherosclerosis

21Chemical Biology and Molecular Imaging

http://cbmi.m.u-tokyo.ac.jp/

Our research field is so-called chemical biology. Our research groupfocuses on the design, synthesis, and development of small
molecular chemical probes for biological and medical research.
These include fluorescent probes for visualizing various eventsoccurring in living cells and animals. We are also collaborating withmedical surgeons to establish an intraoperative diagnostic
technique by using our fluorescent probes for rapid and sensitive
detection of tumor site.
Establishment of rational design strategies for various small
molecular chemical probes● Development of novel fluorescence probes, photosensitizer, caged
compounds, and Raman probes● Biological applications of developed photo-functional chemicalprobes in living biological samples; for example, in vivo/ex vivo
detection and therapy of tumors in mice models and clinicalspecimens.
●

Biosystem Construction and Control

http://www.bme.gr.jp/bme_E/

Our research fields include medical engineering technologies
represented by the artificial organs. Especially in the research of
the artificial heart, the goat whose heart was replaced with the
new type of the total artificial heart survived for more than threemonths. To rescue the life of cardiopulmonary arrest patients, thecompact emergency life support system has been developed.
Other than these, researchs and developments of bio-compatible
materials, sensors, new diagnostic devices and an implantableartificial kidney have been performed.
Artificial heart
Emergency life support system● Hybrid technology of biological and artificial materials● New blood pumps● Implantable pressure sensor● Implantable artificial kidney●●

Integrative Genomics

Helical flow total artificial heart (HFTAH), hybrid cannula andcompact emergency life support system (ELSS)

https://www.h.u-tokyo.ac.jp/patient/depts/genomeshinryou/

Our goal is to achieve clinical application of various types ofgenomic analysis, including cancer and other disorders. We focus
on multi-omic analysis by using clinical samples to develop a novel
cancer genomic profiling test and to establish novel therapeutics
and biomarkers to drug sensitivity. We will also integrate
pathological findings and genomic data, in collaboration with“
Next-Generation Precision Medicine Development Laboratory”.

Multi-functional Cancer Genomic Profiling: Todai OncoPanel (TOP)22

Clinical application of Todai OncoPanel 2, a novel
cancer genomic profiling test, originally developed
at the University of Tokyo● Standardization of handling of pathological tissue
samples and digital pathology● Genomic/Epigenomic sub-classification of specificcancer types● Drug sensitivity analysis by using organoid
3D-cultures●

Platform for Integrative Genomic Analysis

Neuroscience

Neuropathology
Elucidate the pathomechanism of neuronal degeneration and death in major
neurodegenerative disorders (e.g., Alzheimer disease, Parkinson disease), anddevelop novel strategies for disease-modifying therapies.
Mechanism of Ab production, aggregation and clearance
Function of b-amyloid binding proteins (e.g., CLAC)● Mechanism of aggregation and neurotoxicity of a-synuclein● Pathological function of familial Parkinson disease gene LRRK2● Strategies for development and validation of disease modifying therapies for
Alzheimer disease● Mechanism of extracellular release and propagation of tau protein● Pathological function of TDP-43 and FUS in amyotrophic lateral sclerosis●●

Phosphorylated α-synuclein deposited in Lewy
bodies of Parkinson's disease and Lewy body disease

Neurochemistry

http://www.neurochem.m.u-tokyo.ac.jp/

Our brain is able to recognize and memorize external and internal events asthey occur. A functional neural network further stands out by its capacity to
extract patterns and rules, and to associate them with abstract meaning andaffective valence. What are the local and global spectra of the molecularsignaling events in neurons that underlie such complex information
processing at the systems level? Are these events, in turn, converted into
more profound modifications of the synaptic wiring mechanisms? To addressthese issues, we are currently investigating the chemistry and physiology ofvarious neuronal protein complexes near and at synapses.
Understanding molecular and circuit mechanisms controlling memory andemotional behaviors, through integration of state-of-the-art in vitro and in vivo
neurobiological techniques in molecular optogenetics/imaging, geneticalcircuit tracing, and quantitative and behavioral experiments in combination
with genetically modified mice and gene transfer using viral vectors.
● Optical and molecular investigation (including real-time imaging and opticalmanipulation) of biochemical signaling in single synapse, synapse to nucleus,
and living brain circuits that are involved in activity-dependent modification ofneural circuit function and behavior.
●

A. Single-synapse imaging (left) and frequencynumber response profile (right) of CaMKIIa andcalcineurin
B. Visualization of migrating neurons (green) andradial glial fibers (red) during corticogenesis
C. Novel object recognition task

23

Child Neuropsychiatry
Main diseases of our current research are autism spectrum
disorder (ASD), ADHD, Tourette syndrome and childhood
Obsessive-compulsive disorder (OCD). From the viewpointof development of brain and mind, we are trying toinvestigate pathogenesis of these diseases by integrating
phenomenological, neuropsychological, brain-imaging andgenetic studies. We are also applying this integrative
approach to treatment research for patients with these
diseases.

Comprehensive assessment for adults with ASD

Relationship between ASD, TS, and OCD

Only ASD
25%

Tourette syndrome (TS)ASD with
other mental
disorders
75%

Tics
Persistent deficit insocial communicationand social interaction“Just right” perception

Anxiety disorders

ASD

Stereotypy

Persistency

OC symptoms

OCD

Trait of anxiety in STAIState of anxiety in STAI

75% of adults with ASD werecomorbid with mental
disorders.
Large discrepancy was foundbetween self-rating andobjective assessment aboutanxiety in adults with ASD.
19%

81%
59%

39%

41%
61%

Anxiety disorder or higher than cut-off scores in STAI

Hyperdirect pathway

Indirect

Cortex＋Striatum

Dopaminergic
GABAergic
Glutamatergic

DirectNon Anxiety disorder or lower than cut-off scores in STAI

Correlation between Obsessive-Compulsive

Caudate & Putamen(OC) Symptoms, Tics, and Global Functioning
Epidemiological, behavior phenotype, neuropsychological,
pathway －pathway
D2(－)
D1(＋)
Tic Symptoms
GlobalOC Symptom＋＋
genetic and treatment study of Tourette syndrome andDimensions(YGTSS total
Functioning
－
tics)
(GAF)
Globus pallidus SN pars compacta
childhood OCD
externa
Aggression
0.318 *
-0.297 *Sexual/Religious
0.368**-0.225● Brain-imaging study of ASD, ADHD and Tourette syndrome－
SN pars reticulata－
Symmetry
0.356 **
-0.218Subthalamic
Thalamus/Ventral tegmentum● Genomic and epigenomic analysis of ASD
Contamination
0.189-0.254†nucleus＋ Globus pallidus interna
Hoarding
0.177-0.075● Development of predictor of parent training for ADHD
Model of Cortico-striatal-thalamic-cortical pathway in TS
Miscellaneous
0.212-0.239†● Effectiveness study of early intervention for autisticpreschoolers and group cognitive behavior therapy for adults with ASD● Investigation on clinical evaluation and psychological education for adults with developmental disorders●

Neuropsychiatry

http://npsy.umin.jp/en/

Our department mainly investigates schizophrenia and autistic spectrum
disorder s not only by biological approaches which integrate
neuroimaging, genetic and animal studies, but also by psycho-social
approaches. We also promote the systematic clinical research training
programs and the cooperation with the basic neuroscience research.

Comprehensive research for AYA(Adolescent and Young Adult) for bettermental health Care project (CAYAC project)● Prospective population-based birth cohort study aimed at investigating
physiological and psychological development, including self-regulation,
during adolescence (The Tokyo Teen Cohort study: TTC)
● Research for psychosocial support of AYA generation with 22q11.2
deletion syndrome●

Multi-modality neuroimaging in neuropsychiatry using a combination of high-resolution MRI, EEG, MEG, NIRS, and PET

Neurology
Our Department is conducting research programs to elucidate
the pathophysiological mechanisms of neurological diseases
including neurodegenerative diseases, immune-mediateddiseases and neuromuscular diseases, and to establish newtherapeutic approaches for these diseases. We are also
providing excellent training programs to become a boardcertified neurologist.

https://www.utokyo-neurology.org/
ůƵĐŝĚĂƚŝŶŐŵŽůĞĐƵůĂƌďĂƐŝƐŽĨŶĞƵƌŽůŽŐŝĐĂůĚŝƐĞĂƐĞƐĂŶĚĚĞǀĞůŽƉŵĞŶƚŽĨŵĞĐŚĂŶŝƐŵͲďĂƐĞĚƚŚĞƌĂƉǇ

DŽůĞĐƵůĂƌďĂƐŝƐ

24

ŐĞŶĞ

ĚĞǀĞůŽƉŵĞŶƚŽĨŵĞĐŚĂŶŝƐŵͲďĂƐĞĚƚŚĞƌĂƉǇ
ĚŝƐĞĂƐĞŵŽĚŝĨǇŝŶŐƚŚĞƌĂƉǇ

ŐĞŶĞ
ŐĞŶĞ
䋮䋮䋮

Molecular Genetics (identification of disease genes anddevelopment of therapeutic approaches)● Molecular pathophysiology of neurological diseases (protein
structures and functions)● Immune-mediated diseases (autoantibodies)● Neurophysiology and cognitive neuroscience (magnetic stimulation,
NIRS, MEG, PET, and fMRI)● Neuropathology of neuromuscular diseases (pathological studies
on biopsy and autopsy materials)● Multicenter-based clinical research●ŶĞƵƌŽŶĂůĚǇƐĨƵŶĐƚŝŽŶ

ŶĞƵƌŽĚĞŐĞŶĞƌĂƚŝŽŶ

Neurosurgery

http://www.h.u-tokyo.ac.jp/neurosurg/

The 21st century has been designated as "The Century of the Brain". To lead Japanese
surgical neuroscience, we have devoted our activities to the following: advanced clinicalneurosurgery, neuroscience research and graduate and postgraduate education.
Skull base surgery in managing benign or malignant skull base tumors and cerebrovasculardisorders● Genetic analysis of cerebrovascular diseases and benign brain tumors● Functional neurosurgery including epilepsy surgery● Multi-omics analysis of brain tumors (genetic analysis)● Development of new therapeutic strategies for malignat
brain tumors● Development of novel fluorescence probes for brain tumors● Radiogenomics analysis of brain tumors● Cinical study on gamma-knife surgery● Application of brain functional imaging for neurosurgery● Development of surgical simulation method for AI and
XR technology● Cognitive neuroscience using intracranial EEG● Development of brain-machine interface●

Pre-operative simulation using
3D-fusion images

Development of brain tumorspecific fluorescent probe25

Social Medicine

Preventive Medicine([SORUDWLRQRISUHYHQWLYHWKHUDSHXWLFLQWHUYHQWLRQVIRUGLVHDVHVE\JHQRPLFV LQIRUPDWLFV&RPSUHKHQVLYHJHQRPLFVWRXQGHUVWDQGFHOOXODULQWHUDFWRPHLQFDQFHUHQYLURQPHQWV
*HQHWLFEDFNJURXQGDQGOLIHVW\OHGULQNLQJDQGVPRNLQJ 
WKDWDUHULVNIDFWRUVIRUVWRPDFKFDQFHU*DVWULF&DQFHU*HQRPH$QDO\VLV,PPXQHUHSHUWRLUHSURILOLQJWRFODULI\LQGLYLGXDOV¶LQWULQVLFH[WULQVLFLPPXQH
HQYLURQPHQWV&OLQLFDOVDPSOHV,GHQWLILFDWLRQVRIWXPRUVSHFLILF
LPPXQRJOREXOLQVDQGWKHLUDQWLJHQVWRGLVFRYHUSUHYHQWLYHWKHUDSHXWLF
DSSURDFKHVIRUFDQFHUV$OFRKROUHODWHGPXWDWLRQDOVLJQDWXUH&HOO5HSRUWV

6FLHQFH$GYDQFHV+LVWRSDWKRORJLFDOLPDJHDQDO\VLVWRFRQWULEXWH
WRWKHPHGLFDOHTXDOL]DWLRQKLVWRORJ\LPDJHV

1HDUHVWQHLJKERU
VHDUFK«

3UHGLFWLRQRIVRPDWLFPXWDWLRQV«*UDPPDWUL[*HQRPHSURILOHVLQ7&*$'HHSWH[WXUHGLP

Comprehensive genomics; to understand cellularinteractome in cancer environments.
● Immune repertoire profiling; to clarify individuals' intrinsic /extrinsic immune environments.
● Histopathological image analysis; to contribute to the medical equalization.
● Single cell genomic analysis of tumor microenvironment.

Public Health$QDO\VLVRIOLJDQGUHFHSWRUPHGLDWHGFHOOFHOOLQWHUDFWLRQV&RQWHQWEDVHG,PDJH5HWULHYDO'HHS1HXUDO1HWZRUN

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PLFURHQYLURQPHQW

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Our goal is to discover appropriate intervention points forthe prevention and therapeutics for issues in health careand hygiene, with special focuses on malignant tumors,from the viewpoints of genomic and information
sciences. Based on bioinformatics for such complex ecosystems of wide varieties of cells, such as large-scale
genomic information at single cell resolution and multidimensional histological image information, we are
exploring preventive / therapeutic targets or biomarkers,
and also analyzing their biological significance indiseases.

https://plaza.umin.ac.jp/prm/  GULYHUJHQHV
 %5&$QHVV DQG06,

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 



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6LQJOHFHOOWUDQVFULSWRPHRIKXQGUHGVRIWKRXVDQGVRIFHOOV'75

Exploration of preventive/therapeutic interventions
for diseases by genomics & inforamatics

http://publichealth.m.u-tokyo.ac.jp/

Public health is the science and art of preventing disease,prolonging life, and promoting health and quality of life
(QOL) through organized community effort. Through studies
in various fields and laboratories, our department aims toadvance research, support policy development, and promote
education toward these ends.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental health● Health services research●●Physician distribution by municipality in Japan

26

Forensic Medicine

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University,and Department of Forensic Medicine, School of Medicine, International
University of Health and Welfare.
Application of imaging modalities such as CT
and MRI for death investigation● Age and stature estimation and sex
determination using CT● Biomechanical properties of human tissue● Diagnosis of drowning● Research for infectivity of SARS-CoV-2 indecedents● Analysis and pathophysiology of illegal drugs
including new psychoactive substances● Application of relatively new DNA testing
method for practice of forensic medicine●

Biomedical Informatics

Forensic autopsy room

CT room

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords of the target domain are medical and clinicalinformation systems, next-generation electronic health record
systems, virtual health care environment, mobile health, and AI
including natural language processing as well as machine learning.
Automatic Mapping from Clinical Case Dara toDevelopment and application of clinical ontology
Knowledge of Disease Transition● Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence and mobile healthcare system●

27

Internal Medicine

Cardiovascular Medicine

https://cardiovasc.m.u-tokyo.ac.jp/

We aim to provide the finest medical care for all cardiovascular diseases, including heart failure, ischemic heart disease,arrhythmia, valvular disease, structural heart disease, pulmonary hypertension, adult congenital heart disease, and arterial
diseases. In particular, we have treated the largest number of patients with serious heart failure in Japan. In collaboration with the
Department of Cardiovascular Surgery, we would like to work as the last bastion against heart failure. Moreover, with ongoingbasic research and translational studies, we are developing new diagnostic modalities and treatments for refractory diseases.
Investigation of disease pathophysiology (severe heart failure, arrhythmia,
pulmonary hypertension, etc.) and development of novel therapies● Analysis of genome, epigenome, and transcriptomes in various
cardiovascular diseases● Investigation of pathophysiology of cardiomyopathy using iPS cells● Research on the role of chronic inflammation in the pathogenesis of various
cardiovascular diseases● Epidemiology and prevention of Cardiovascular disease● Artificial Intelligence in Cardiology● Improvement of imaging techniques (echocardiography, MRI, CT, SPECT) for
cardiovascular diseases● Clinical research of severe heart disease, pulmonary hypertension,
Arrhythmia●

Respiratory Medicine
The number of patients with pulmonary diseases is increasing. At the
Department of Respiratory Medicine, we conduct a wide variety ofbasic and clinical research. We focus on molecular analysis of lungdiseases to develop novel treatment strategies.

http://kokyuki.umin.jp/
5HVHDUFK㻹㼛㼡㼟㼑㻌㼙㼛㼐㼑㼘㻌㼛㼒㻌㻺㻿㻯㻸㻯㻱㻳㻲㻾 㻸㻤㻡㻤㻾%HGVLGH㻱㻳㻲㻾㻙㼀㻷㻵

Molecular profiling of lung cancer● Discovery of novel prognostic biomarkers in lung cancer● Targeted clinical sequencing of lung cancer specimens● Clinical research using the lung cancer database● Molecular analysis of COPD using animal models● Molecular analysis of asthma● Molecular analysis of pulmonary fibrosis using animal models● Clinical epidemiology using the DPC database● Case reports●%HQFKVLGH㻭㻸㻷㻙㼀㻷㻵

㻳㼑㼚㼑㼠㼕㼏㼟
㻵㼙㼙㼡㼚㼛㼘㼛㼓㼥㻱㻹㼀

5HVSLUDWRU\GLVHDVHV㻹㼛㼡㼟㼑㻌㼙㼛㼐㼑㼘㻌㼛㼒㻌㻿㻯㻸㻯㼕㼚㼍㼏㼠㼕㼢㼍㼠㼕㼛㼚㻌㼛㼒㻌㻾㼎㻝 㼍㼚㼐㻌㼀㼞㼜㻡㻟㻱㼜㼕㼓㼑㼚㼑㼠㼕㼏㼟㻿㼠㼑㼙㻌㼏㼑㼘㼘㼟㻺㼛㼚㻙㼏㼛㼐㼕㼚㼓㻌㻾㻺㻭㼟28

Gastroenterology

http://gastro.m.u-tokyo.ac.jp/med/home.html

Our Department of Gastroenterology is one of the top institutions in the world in
the treatment of hepatocellular carcinoma by unique ablation(RFA) andgastrointestinal/pancreatobiliary cancer/stone by endoscopic manipulation(ESD&ERCP). The goal of our department is to accurately diagnose and give thebest available treatment to these patients, and to this end, we are performing awide variety of basic as well as clinical research.
Development of better therapeutic strategy for hepatitis B and C
Elucidation of hepatocarcinogenesis mechanism in viral hepatitis● Development of a better therapeutic modality for hepatocellular carcinoma& metastatic liver tumor● Elucidation of gastric injury mechanisms by Helicobacter pylori● Elucidation of stem cell and carcinogenic mechanism of gastrointestinal cancer● Development of therapeutic strategy for advanced pancreatobiliary cancer● Development of a better endoscopic therapeutic modality for pancreatobiliary
cancer/stone● Development of better diagnostic & therapeutic strategy for chronic pancreatitis● Development of an endoscopic en bloc resection method for early gastric, esophageal and colonic cancer● Elucidation of the mechanisms of metabolism-associated liver diseases● Development of better diagnostic & therapeutic strategy for small intestinal diseases●●

Nephrology / Endocrinology

http://www.todai-jinnai.com/

We are investigating the pathophysiology of renal and endocrine
disorders for the development of innovative diagnostic and therapeutic
tools.
Analysis of pathophysiology and development of therapy of chronic kidneydisease● Abnormal oxygen metabolism of kidney disease● Epigenetic changes in CKD● Development of biomarkers and therapy of acute kidney injury● Renal physiology and morphology● G protein signaling in health and disease● Clinical and basic investigation of bone and mineral disorders● Pathophysiology of hypertension●

Nutrition and Metabolism
We are investigating to reveal the molecular mechanisms underlying the development of metabolic diseases (diabetes
mellitus, lipid metabolic disorders, obesity disease, sarcopenia, metabolic syndrome and atherosclerosis) using
interdisciplinary approaches and state-of-the-art technology including genetically engineered model animals, iPS cells,
omics analyses (epigenome, metabolome etc), human genetics, clinical epidemiology and bioinformatics. Our major goal
is to develop mechanism-based fundamental treatment and prevention strategies for the metabolic diseases.
●

Elucidation of molecular mechanism of insulin resistance linked to obesity,

sarcopenia and development of novel treatment focusing on AdipoR,
myokines etc

Genetic engineering
Development ofbest-in-class medicine
Animal model
Based on 3-D structure

Functional analyses by
iPS and genome editing

Epigenetic analysis of the mechanisms of metabolic control and their disruption
Liver
Brain
in type 2 diabetes and obesity
IoT,AI, ICT● Elucidation of the molecular mechanism of metabolic diseases andSpleenGutdevelopment of novel treatment using iPS cells
Immunemicrobiota
Bioinformatics● Molecular mechanism of insulin signal transduction● Molecular mechanism of insulin secretory defect in type 2 diabetes
Vasculature
Adipocytes
Intestine● Genetic susceptibility and risk factors of type 2 diabetes
Human genetics● Using IoT, AI, development of accurate diagnostis, prevention, treatment
algorithm for type 2 diabetes
MuscleTranscriptome
Metabolome● Molecular mechanism of adipogenesis and obesity
Genome Epigenome
GWAS● Transcriptional regulation of lipid metabolism
Integrated analyses● Molecular mechanism of atherosclerosis● Mouse genetic models of diabetes, lipid metabolism disorder and atherosclerosis●

29

Hematology and Oncology

http://www.u-tokyo-hemat.com/

We investigate the pathogenesis, diagnostic methods, and novel therapeutics of hematological diseases by the comprehensive
use of research technologies in molecular biology, cellular biology, developmental engineering, and genomic science. Studies
about transcriptional regulation and signal transduction in hematopoiesis and analyses of regulation of hematopoietic stem cells(OXFLGDWLRQRIWKHJHQRPLFDQGPROHFXODUPHFKDQLVPVare promoted. We also implement basic and clinical studies
based on genomics, regenerative medicine, immunotherapy and
XQGHUO\LQJKHPDWRSRLHVLVDQGOHXNHPRJHQHVLVtransplantation medicine, which aim at application totherapeutic strategies.
Mechanisms in the regulation of self renewal anddifferentiation in hematopoietic stem cells● Comprehensive genomic and epigenetic analysis ofhematological malignancies● Elucidation of the molecular mechanisms underlying
the pathogenesis of leukemia● Development and analysis of mouse models of
leukemogenesis● Regenerative medicine and pathogenesis study
based on human iPS cell technology● Adoptive immunotherapy with T cells engineered
with chimeric antigen receptor or T cell receptor forcancer
●+6&VH[SDQVLRQE\581;
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GHYHORSPHQWDOHQJLQHHULQJ

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RIUHJHQHUDWLYHPHGLFLQHDQG
SDWKRJHQHVLV(OXFLGDWLRQRIDVSHFLILFPDUNHURIOHXNHPLDVWHPFHOO(OXFLGDWLRQRIDUHVSRQVLEOHJHQHDQGFORQDOHYROXWLRQRIIDPLOLDOSODWHOHWGLVRUGHU&RPSUHKHQVLYHDQDO\VLVRIJHQRPLFWUDQVFULSWLRQDODQGHSLJHQRPLF
DEHUUDWLRQVLQKXPDQVDPSOHV
6LQJOHFHOODQDO\VLV(OXFLGDWLRQRIDUHVSRQVLEOH
JHQHDQGIXQFWLRQDODQDO\VLVLQIDPLOLDO0'6(SLJHQHWLFDQDO\VLVRI
OHXNHPLDUHODWLYHJHQHVElucidation of the genomic and molecular mechanisms underlying hematopoiesis andleukemogenesis

Allergy and Rheumatology
The primary aim of our department is to provide best care and support to patients with rheumatic disease. It is our mission
to provide excellent clinical care while seeking to better define the causes, stratification of patients, and best treatment
approaches for rheumatic disease. To this end, we have to clarify the mechanisms for autoimmunity seen in rheumatic
disease. We perform basic and clinical research to translatelaboratory findings into novel therapeutic approach by combining
genetics, transcriptome informatics and immunology (Ota M et al.
Cell. 2021). We think research of human immunology in collaboration
with patients is the key to overcome rheumatic disease.
Genome/transcriptome analysis of immunological diseases
Disease classification and diagnosis with genome/transcriptomeof immunological diseases● Identification of molecular pathway related to prognosis in SLE● Identification of molecular pathway related to prognosis inpolymyositis/dematomyositis● Identification of molecular pathway related to prognosis insystemic sclerosis● Molecular analysis using conditional knockout mice
● Molecular analysis using iPS cells●●

Infectious Diseases
We are investigating both clinical and basic aspects in infectious diseases, inparticular, on HIV infection and hepatitis viral infections, the latter of which is
the major cause of liver diseae worldwide. Our research topics cover the wide
areas in microbiology, immunology and pathobilology of infectious diseases,
including viral and bacterial infections.
Clinical studies of HIV infection
Treatment and prevention of viral hepatitis● Molecular pathogenesis of hepatocellular carcinoma in HCV
infection● Pathogenesis of extrahepatic manifestations and its control in
HCV infection● Molecular pathogenesis of hepatocellular carcinoma in HBV
infection● Molecular pathogenesis of hepatitis B viral infection● Pathogenesis of influenza viral infection● Molecular epidemiology and pathogenesis of bacterial infection● Host defenses to microorganisms● Mechanism of multi-drug resistant microorganisms●●

30

http://psmut.umin.ac.jp/

Stress Sciences and Psychosomatic Medicine
The targets of our laboratory include stress-related diseases such as primaryheadaches and lifestyle-related diseases, eating disorders and malignancies.
The goals of our work are to determine the mechanisms of these conditions,to develop objective markers for diagnosis and severity, and to discover new
treatment approaches using ecological momentary assessment (EMA),
biochemical assessment of eating-related molecules, and physiologicalassessment of autonomic nervous function.
We are using ecological momentary assessment (EMA) techniques tocollect and evaluate subjective and objective data including physicalactivity and autonomic nervous function in natural settings in stress-relateddiseases. We are also developing new treatments using these methods.
● Investigation into the pathophysiology, psychopathology andneurobehavioral basis of stress-related diseases by use of ecologicalmomentary assessment methods● Using heart rate and blood pressure variability, we are investigating
autonomic nervous function in eating disorders. This work uses non-linear
analyses such as fractal analysis, as well as linear analysis.
● We have developed an egogram questionnaire, which we refer to as the
TEG.
●

Clinical Laboratory Medicine

http://lab-tky.umin.ac.jp/

The main goal of our research projects is the development of new and useful laboratory tests, and elucidation ofpathophysiology of diseases through laboratory tests.
(Patho)physiological roles of lipid mediators, and its application tolaboratory medicine● Platelet biology, Development of laboratory diagnosis inthrombosis and hemostasis● Echocardiographic studies of the pathophysiology of valvular heartdisease and the hemodynamics● Cancer genomic medicine using next generation sequencing● Clinical introduction of the assay of oxidized/reduced albumin● Neuroscience research using magnetoencephalography and noninvasive brain stimulation● Promotion of medical-science-engineering cooperation●ůŝŶŝĐĂů >ĂďŽƌĂƚŽƌǇ DĞĚŝĐŝŶĞ
ŶĂůǇƐŝƐŽĨůǇƐŽƉŚŽƐƉŚŽůŝƉŝĚƐǁŝƚŚŵĂƐƐƐƉĞĐƚƌŽŵĞƚƌǇ

ĞƉĂƌƚŵĞŶƚ ŽĨ ůŝŶŝĐĂů >ĂďŽƌĂƚŽƌǇ ;,ŽƐƉŝƚĂůͿTransfusion Medicine

http://square.umin.ac.jp/traf-tky/

The Department of Transfusion Medicine aims the achievement ofsafe and appropriate transfusion practice in the hospital, and forthis purpose, controls, tests and supplies all blood products fortransfusion.
The research fields include:
Detection of red cells/ leukocytes/platelets antigens/antibodies
Development of new anti-angiogenic strategies for thetreatment of solid tumors● Investigation on the pathophysiology of the immunologicaladverse effects of transfusion● Clinical study for the safety of autologous blood donation●●

31

Reproductive, Developmental andAging Sciences

Reproductive Endocrinology

http://www.h.u-tokyo.ac.jp/patient/depts/a_joseika01/index.html

We manage women's reproductive health comprehensively throughout
their respective life stages (adolescence, reproductive ages, menopause,and post-menopause). We also aim to develop advanced reproductive
techniques, which could be practiced with higher success rates andimproved safety, based on experimental and clinical research.
Establishment of effective and low-risk treatment for infertility
Development of assisted reproductive technology● Understanding of interaction between the endometrium and embryo
during the implantation period● Study of pathophysiology of endometriosis / adenomyosis● Understanding of local regulation of folliculogenesis● Technical development of advanced endoscopic / minimally invasive
surgery● Development of hormone replacement therapy for perimenopausal /postmenopausal women● Health care for women● Development of oncofertility●●

Gynecologic Oncology

ICSI (intracytoplasmic sperm injection)

https://www.h.u-tokyo.ac.jp/english/centers-services/clinicaldivisions/gynecologic-surgery/index.html

We perform basic research focusing on genetic and epigenetic analyses in gynecologic oncology to establish novel
diagnostic and therapeutic tools. In the clinical aspects, we provide life-long medical care for the patients with endometriosis
and/or adenomyosis and perform advanced gynecologic surgeries such as adenomyomectomy and radical trachelectomy.
We actively perform endoscopic and robot-assisted surgeries in gynecologic oncology.
Optimization of surgery for fertility preservation in
endometriosis, adenomyosis and uterine fibroid● Minimally invasive surgery (laparoscopic and robotassisted surgery)● Genomic medicine in hereditary gynecologic cancers● Development of diagnostic / therapeutic methods forgenomic and epigenomic analyses● Development of novel therapeutic tools to target DNA
repair pathway● Development of new gynecologic medical system using
artificial intelligence●

Somatic KRAS mutation in adenomyosis

32Perinatal Medicine

http://www.h.u-tokyo.ac.jp/patient/depts/a_joseika03/index.html#ninpu

The researches are on going for development of precise prenatal
diagnosis on the fetal status using ultrasonography and for better
understanding on pathology of perinatal diseases. We are also focusing
on the immunological aspects and inflammation in patho- physiology ofpregnancy. Our goal is to develop the therapy and prevention methods
for recurrent pregnancy loss, pregnancy induced hypertension, preterm
labor, and cerebral palsy.
Prenatal diagnosis of abnormal fetuses using three dimensional
ultrasonography● Management of recurrent pregnancy loss
● Management of complicated pregnancy● Management of preterm labor● Prevention of cerebral palsy of the newborn● Development of novel therapy for hypertensive disorders of pregnancy.
●

Three dimensional ultrasonography of fetus

Molecular and Cellular Reproductive Medicine
We investigate the molecular mechanisms of reproductive functions
using the knowledge and techniques of molecular and cellularbiology and genetics.
Our studies are focusing on the pathophysiological mechanism of sex
steroid hormones to elucidate how these hormones effect on
reproductive phenomena including embryogenesis, spermatogenesis
and fetal development, and on the prenatal genetic diagnosis.
Effect of sex steroid hormones on reproductive medicine
Molecular mechanisms of embryogenesis● Analysis of implantation mechanism● Pathophysiology of ovarian aging and elucidation of its mechanism● Molecular analysis of follicular atresia●●

Molecular mechanisms of sex steroids

Pediatrics / Developmental Pediatrics

http://square.umin.ac.jp/ped/

We are studying all aspects concerning the health of infants, children and adolescents.
We have achieved very important contributions to clarify the molecular pathogenesis of pediatric disorders.
Molecular diagnosis and analyses of hematological malignancies and solid tumors
Multi‐institutional comparative clinical studies on leukemia and solid tumors● Molecular diagnosis, analysis and collaborative treatment of pediatric renal diseases● Molecular analysis and diagnosis and collaborative treatment of
endocrine/metabolic diseases and diabetes● Diagnosis, molecular analysis and collaborative treatment of congenital
heart diseases● Molecular mechanism of Neonatal immune tolerance● Comprehensive analysis of biomarkers in neonatal diseases● Microbiome and immune function in neonates● Immunity of neonates born to mothers with systemic autoimmune
diseases● Neurocognitive effects of intrauterine infection and environmental toxins● Diagnosis and comprehensive treatment of neuromuscular disorders● Molecular diagnosis and treatment of mitochondrial disorders● Early intervention of developmental disorders● Patho-physiological analysis by digital data in pediatric critical care
● Protective respiratory care by trans-pulmonary pressure in children● Development of educational program of transitional care●●

33

Pediatric Surgery
Pediatric surgical diseases have great variety. In our department allkinds of pediatric surgical conditions are treated, and in these fetal
and neonatal surgical care is our main interest. We also treat many
pediatric patients using minimally invasive surgeries such as
laparoscopy and thoracoscopy.
Fetal surgery and treatment
Pediatric minimally invasive surgery● Pediatric robotic surgery● Biliary atresia and biliary dilatation: their treatment and long-term
prognosis● The treatment by regenerative medicine of air way malacia andstenosis● Development of pediatric surgical models● Association between pediatric surgical diseases and intestinal
microbiota● Assessment of pediatric surgical procedures using nation-wide data●●

EXIT(ex utero intrapartum treatment):
Tracheostomy on a fetus with laryngeal atresia

Pediatric Oncology
We investigate the molecular pathogenesis
in the field of pediatric hematology andoncology. Using comprehensive genomic
analysis technology, we focus on not only
somatic genomic alterations, but also
germline background underlying onset anddevelopment of pediatric hematologic/
oncologic diseases. Through collaboration
with related fields, we aim to reveal
etiology of pediatric diseases.
Genomic research for pediatric leukemia
Genomic research for pediatric solid
tumor● Germline genomics for pediatric cancer● Pharmacogenomics for pediatric cancer●●

Effect of novel RARB-fusion detected in atypical acute promyelocytic leukemia

Geriatric Medicine

https://www.h.u-tokyo.ac.jp/patient/depts/rounen/

The Department of Geriatric Medicine, established in 1962, is the firstdepartment of Geriatric Medicine in Japan. The staff physicians arehighly trained and experienced in managing complex cares.
Comprehensive cares including assessment and treatment of chronic
diseases, geriatric conditions, and frailty are provided to ensure qualityof life and health in elderly patients. Our research interests are as
follows:
Molecular mechanisms of vascular calcification
Molecular mechanisms of sarcopenia● Inhibition of cognitive decline using antihypertensive drugs● Cares and burdens of family caregivers of patients with dementia● Risk factors for adverse drug events● Association of sex hormones and vitamins with geriatric conditions● Novel gene responsible for locomotive syndrome, including
osteoporosis● Molecular mechanisms of vascular injury in sleep apnea syndrome● Polypharmacy and frailty●●

34

A typical brain MRI image and a brain perfusion SPECT image of an
Alzheimer's disease patientSurgical Sciences

Thoracic Surgery

http://cts.m.u-Tokyo.ac.jp

We specialize in surgical treatment and oncology for thoracic
malignancies including primary lung cancer, pulmonary metastasis andmediastinal tumors. We are conducting a wide range of research from thedevelopment of cancer immunology to minimally invasive surgicalmethods such as thoracoscopic/robot-assisted surgery.Since 2014, The
University of Tokyo Hospital has been certified as the sole lung transplantinstitute in Tokyo. In 2020, the number of lung transplants performed
became the highest in Japan. We are conducting clinical research on lungtransplantation and basic research using animal models.
Minimally invasive therapeutics for chest malignancies
Clinical and basic oncology of lung cancer and thymic epithelial
neoplasms● Clinical and basic research on lung transplantation●●

Cardiovascular Surgery

http://cts.m.u-tokyo.ac.jp/cardiac-surgery

We are leading in Japan by annual surgery case volume of 400. New
knowledge and techniques are actively applied clinically. Many clinicalresearch projects are going on along with routine clinical activities. Ourlaboratories have been also carrying out a large variety of basic research.
●

Clinical research
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Improvement of long-term results of heart transplantation
ventricular assist device for end-stage heart failure
valve plasty and valve-sparing operation
Minimally invasive surgery
Treatment of complex congenital heart disease

Basic and experimental research●●●

Development of new control system for ventricular assist device
Development of myocardial regenerative therapy
Development of a new suture device under endoscopic environment

Ventricular assist devices clinically available in Japan35

Gastrointestinal Surgery

http://gibes.m.u-tokyo.ac.jp/

Our goal is to cure the cancer patients by much better surgery. The development of better surgical methods have the highest
priority. Better surgery means radicality of the cancer, minimal invasiveness, and good QOL after surgery. Recently, robot assistedtransmediastinal (non-transthoracic) radical esophagectomy has been developed, which shows less postoperative pulmonary
complications and better QOL after surgery compared with conventional esophagectomy.
●

Cure by much better surgery
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Robot assisted transmediastinal esophagectomy for esophageal cancer
Robot assisted gastretomy for gastric cancer
Laparoscopic endoscopic cooperative surgery (LECS) for gastric andduodeneal tumor, non-exposed endoscopic wall-inversion surgery (NEWS)for gastric tumor
Laparoscopic gastrectomy for function preserving (proximal, distal andpylorus preserving gastrectomy)

conventional

Research for carcinogenesis, progression, diagnosis and treatment
●
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Inflammation and gastrointestinal carcinogenesis
Activatable fluorescence imaging probe for esophageal and gastric cancer
Oncolytic viral therapy for esophageal cancer
Genetics and epigenetics for esophageal and gastric cancer
Early detection of gastrointestinal cancer by new biomarkers
Immunotherapy based on intratumoral immune response in gastric cancer

Hepatobiliary Pancreatic Surgery

transmediastinal (non-transthoracic)

http://www.u-tokyo-hbp-transplant-surgery.jp/

We perfom nearly 150 hepatectomies in patients with hepatobiliary
malignancies and nearly 90 pancreatectomies in patients with pancreatic
neoplasms every year. The first priority is put on the safety of the patients
undergoing surgery. In order to improve the surgical outcome for hepatobiliary-pancreatic malignancies, we conduct wide areas of research such as
analysis of prognostic factors for liver malignancies, intraoperative
diagnostic tools, liver ischemia/reperfusion injury, and liver regeneration.
ICGfluorescent imaging for detecting tumors

The analysis of genetic abnormalities in hepatocellular carcinoma
Development of new methods for the evaluation of liver functional reserve● The evaluation of hemodynamics in the congested liver using ultrasonography● Navigation system during liver surgery● Intraoperative diagnosis using ICG fluorescent imaging● Clinical trials concerning perioperative chemotherapy in hepatic resection forcolorectal liver metastasis● Clinical trials addressing utility of preoperative drug therapy for hepatocellular carcinoma● Vascular reconstraction using criopreserved vein grafts Evaluation of the anti-adhesionmaterials● Development of new artificial vessels dedicated for HPB surgery● Development of anti-adhesion materials●●

Urology

Vascular reconstraction using
criopreserved vein grafts
Preoperative 3D imaging of
the liver constructed bysimulation software

http://square.umin.ac.jp/UT-urology/

We perform more than 1,500 urological surgeries every year, including nephrectomy, cystectomy and prostatectomy, withincreasing trend of laparoscopic maneuvers. Robotic surgery was introduced in 2011. Surgical or non-surgical procedures are
employed for non-cancer disease including chronic renal failure, urinary dysfunction, urinary incontinence and interstitial cystitis.
Genome analysis of renal cancer, renal pelvic cancer, ureteralcancer and testicular cancer● Genome analysis of Corticotropin-independent Cushing’s syndrome● Pathogenesis of interstitial cystitis● A prospective randomized controlled study on the suppression ofcancer● Artificial urinary sphincter for male urinary incontinence● Robot-assisted laparoscopic surgery (prostate, renal, and bladdercancer) (Fig.1)● Immune checkpoint inhibitor for metastatic renal cancer andbladder cancer● Multidisciplinary treatment for locally advanced prostate cancer● Site-directed therapy for oligometastasis of prostate cancer● Salvage robot-assisted radical prostatectomy after radiotherapy● Surgery for chronic renal failure (hemodialysis, peritoneal dialysis
and renal transplantation)● Urogynecology (pelvic organ prolapse)●

36

Fig.1 Surgical scene of Robot-assisted laparoscopic radical prostatectomy

Artificial Organ and Transplantation Division

http://plaza.umin.ac.jp/htokyotransplant/

685 living donor liver transplantation and 47 deceased donor livertransplantation until Dec. 2020. The 5-year survival rate for adult case was 87%,
which is significantly superior to that of the national data (73%).
Surgical technique of liver transplantation: including
right lateral sector graft, APOLT(Auxillary partial
orthotopic liver transplantation)● Hepatic vein reconstraction using criopreserved vein
grafts● Identification of veno-occlusive resions using ICG
fluorescence imaging● Antiviral treatment for hepatitic C and B virus infection
after liver transplantation● Novel strategies in liver transplantation for PBC and
PSC● Expansion of liver transplant indication for HCC● Diagnosis and treatment for acute rejection● Diagnosis and treatment for postoperative infection●

Overall survivals after living donor liver trasnplantation

Hepatic vein reconstraction using
criopreserved vein grafts

Surgical Oncology

http://all-1su.umin.jp/

We have performed basic and clinical research mainly on colorectal cancer
and inflammatory bowel disease. In basic research, we are studying biologicalphenomenon from various point of view such as carcinogenesis, cancer
metastasis, and immunology. In clinical study, we are trying to identify thebest way to treat each patient with the least surgical stress by minimallyinvasive surgery such as laparoscopic surgery and robotic surgery (da Vinci),and preoperative chemoradiation therapy for rectal cancer.
Robot assisted surgery (da Vinci robotic surgery)● Radiosensitivity and chemosensitivity of cancer● Characterization of tumor vasculature and its therapeutic
application● Surveillance of ulcerative colitis● Carcinogenesis in ulcerative colitis● Cancer and autophagy● Development of chemoradioimmunotherapy● Genetic analysis of poorly differentiated colorectal cancer● Intraperitoneal chemotherapy for peritoneal carcinomatosis●

Fig.1 Prediction ofchemoradiosensitivity
in rectal cancer by
DNA microarray
Fig.2 Targeted vsrandom biopsies forsurveillance ofulcerative colitisassociated cancer

Vascular Surgery

http://all-1su.umin.jp/

We have a great deal of experience in treating patients with various
vascular diseases, and we have performed much research on
atherosclerosis, angiogenesis and vascular regeneration. Based on
the research results, we are trying to identify the best way to treat
each patient with the least surgical stress.
Development of a novel method to diagnose and treat thevasculardiseases.
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Vascular regeneration therapy for atherosclerotic obliteransDevelopment of aortic aneurysm model and simulation
Gene analysis of peripheral arterial disease
Visualization of the atherosclerotic lesions with fluorescent probe
Navigation system for less invasive vascular surgery
Analysis of intermittent claudication with dynamic and mechanicalmodel
Dynamic and genetic mechanism of aortic aneurysm expansion
Development of the new prosthesis with small diameter
Hemodynamic analysis of aortic wall after endovascular aneurysm
repairDrug delivery system for aortic aneurysm and peripheral arterial
disease37

http://todai3ge.umin.jp/

Breast and Endocrine Surgery

Clinical activities in the department of breast and endocrine surgery widely range from diagnosis to surgical treatment forbreast cancer, thyroid cancer, and benign tumors of breast, thyroid, and parathyroid. We also place importance on medical
genetics including hereditary breast and ovarian cancer syndrome (HBOC) as well as precision medicine based on cancer
genome information. Our goal and motivation of basic
research are to eradicate metastatic breast cancer inwhich complete cure has yet to be realized.
BRCAness in triple negative breast cancer
Use of droplet digital PCR for quantitative andautomatic analysis of the HER2 status● Detection of the PIK3CA mutation in circulating tumor
DNA in early-stage breast cancer● Impact of CDK4/6 inhibitor palbociclib on activinSMAD2 signaling in estrogen receptor-positive breast
cancer● Stem-like cells of breast cancer● Epigenetic change which is critical for carcinogenesisof breast cancer●●

The immunohistochemical features of BRCA1, AR, p53, CK5/6(One patient with a BRCA1
The immunohistochemical features of BRCA1, AR, p53, CK5/6 (One patient with a BRCA1
promoter-methylated
tumor and two patients with a BRCA1 promoter-unmethylated tumor)
promoter-methylated tumor and two patients with a BRCA1 promoter-unmethylated tumor)

Dermatology

http://www.h.u-tokyo.ac.jp/der/Our department actively performs the following cutting-edge, multifaceted
research projects that will be put into clinical practice in the future.
Molecular mechanisms of immunological abnormalities and skin and lungfibrosis in systemic sclerosis● Development of novel therapies to systemic sclerosis, including B cell
depletion therapy● Relative contribution of various cell adhesion molecules and chemokines toinflammatory conditions● Identification of novel autoantibodies and their clinical significance inconnective tissue diseases● New roles of B lymphocytes, especially regulatory roles, in inflammatory
disorders● Immune-epidermal abnormalities in psoriasis and atopic dermatitis● Pivotal roles of Fli1 in systemic sclerosis● Roles of chemokines and stimulatory molecules in cutaneous lymphoma● Roles of lipid enzymes and receptors in immune-mediated skin diseases● Largest clinical studies on systemic sclerosis in Japan●

Skin fibrosis induced by bleomycin(left) is inhibited in
CD19-deficient mice(right)

Plastic and Reconstructive Surgery
We aim to develop innovative therapeutic interventions for themorbidities associated with plastic and reconstructive surgery. With avariety of state-of-the-art approaches such as gene therapy andmicrovascular surgery, we continuously work on the reconstruction ofskin, fat, muscle and nerve to fight against the intractable diseases.
●

Basic Research
●

●

●

●
●

●

Development of gene therapies for the intractable diseases in plastic
surgery
Realization of the innovative therapies for cutaneous ulcers via direct
cellular reprogramming
Development of the method for perfect tissue regeneration via tissueembryonization.
Elucidation of pathology of vascular anomalies.
Development of new therapeutic intervention for alopecia

Clinical Research
●
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38

Aiming at perfect tissue regeneration through tissueembryonization

Development of a novel reconstruction method for facial nerve palsy and its optimization
Standardization of reconstruction method for eye closure in patients with facial nerve palsy by evaluation of blink function
Evaluation of effectiveness of lymphatico venous anastomosis in early stages of lymphedema
Research on dysphagia after tongue reconstruction after cancer resection
Development of tissue perfusion monitoring system using flexible electronic devices

Oral and Maxillofacial Surgery

http://plaza.umin.ac.jp/~oralsurg/

Our laboratory has been performing a wide range of clinically oriented research in oral-maxillofacial disorders suchas congenital diseases, jaw deformities and tumors in the oral region. Cartilage and bone regeneration using tissue
engineering techniques is our main field of research.
●

Clinical research:

Treatment of facial deformities and malocclusion in patients with cleft lip/palate
Research on facial growth in patients with craniofacial anomalies Reconstruction oforal and maxillofacial area by custom-made artificial bone (CT bone) (clinical trial)
Transplantation of implant-type tissue-engineered cartilage for cleft lip-nose patients(clinical study) QOL study of oral health care system in preoperative cancer patients
Overcoming eating loss (eat-loss) The association between oral disorders andsystemic diseases Development of surgical assisted systems using artificial
intelligence, computer vision, and augmented reality
Research on the treatment of temporomandibular joint disorder using autologous
adipose-derived mesenchymal stem cells

●

●

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●

Basic and experimental research:

Regeneration of bone and cartilage with tissue-engineering approach Molecularbiology of cartilage repair and its application to cartilage regenerative medicine
Development of novel scaffolds for cartilage and bone regeneration In vivo
evaluation of tissue-engineered cartilage and bone Study on the control of mesenchymal cell differentiation Elucidation of epigenetic
abnormalities in oral cancers and oral premalignant lesions Functional analysis of microRNAs in human dental pulp stem cells Study on thecleft lip and osteonecrosis of the jaw using animal models Elucidation of mechanisms of tissue repair by adipose-derived stem cells andmacrophages Analysis of regulatory mechanisms of bone using a reconstitution system of the cellular network in bone metabolism

●

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Orthopaedic Surgery

http://www.u-tokyo-ortho.jp/

Our department was established in 1906 as the first department oforthopaedic surgery in Japan. Since then our efforts have been dedicated toresponding to the needs of patients for orthopaedic care and to related
research. Our department seeks to elucidate the molecular and genetic
backgrounds of bone and cartilage disorders in order to develop
groundbreaking treatments for these conditions. At the same time, we areattempting to establish various clinical devices.
Systemic and comprehensive study for osteoarthritis
Regulation of bone metabolism and Molecular mechanism of osteoclastdifferentiation● Regenerative medicine of joint and nerve by adipose-derived stem cells andrelated technology● Surgical navigation system with a three-dimensional display and navigation robot● Long-life artificial joint by construction of a super-durable lubricious interface of MPC● Prevention of adhesion after tendon repair by hydrogel technology●●

Surgical navigation system

Ophthalmology
Our department applies cutting-edge technologies and knowledge todiagnosis and treatment of eye diseases. We conduct basic researches
involving multi-faculties with molecular biological, immunological, andpharmacological techniques, and clinical studies with epidemiology andbiostatistics.

https://www.todaiganka.jp/

Surgery techniques
Neuronal Cell Death

Physiological studies on vision and eye movements
Development and evaluation of new drug therapies and surgical techniques
OCT images
on glaucoma, or retinal, corneal, and uveal diseases.
● Development of diagnosis and treatment in glaucoma with functional andstructural analysis.
Surgery Training System● Study on mechanisms for maintaining intraocular pressure, andＴＧＦＢＩ genedevelopment of new drugs using clinical samples of glaucoma eyes andgenetically modified animals.
● Further research in the mechanisms of neuronal death in retinal neurons and glial cells, and exploration of usefulneuroprotective agents.
● Development and application of surgery training systems with bionic eyes.
● Improvements in corneal regeneration therapy and development of new therapies in hereditary corneal diseases.
● Study on corneal mechanisms to maintain clarity.
● Research on refractory uveitis and intraocular lymphoma.
● Comprehensive studies on multimodal imaging of structures and functions of macular diseases.
●●

Human TGFBI gene39

Otolaryngology and Head and Neck Surgery

http://utokyo-ent.org/

Our research is composed of both clinical and basic research. Clinical research is conducted by specialized clinics in the hospital,
which experience ear diseases and hearing disorders from neonates to adulthood, head and neck cancer, paranasal diseases,
olfactory and disorders, vertigo and balance disorders and voice and swallowing disorders. Basic and experimental research intomolecular biology, electrophysiology and morphology is conducted in our department's laboratories.
●

Clinical researchCochlear implantation in deaf children and their development of hearing, speech and language
Surgical correction of congenial microtia and atresia and postoperative radical ears to improve
hearing
Quality of life in patients with head and neck cancer to restore speech and swallowing function
Vestibular research on the oculomotor and balance system and myogenic potential
Vestibular rehabilitation by electric stimulation
Survey of eosinophilic sinusitis and refractory allergic rhinitis
Survey and surgical treatment for swallowing disorders and esophageal motility disorders
Clinical sequencing for recurrent / metastatic head and neck cancer
Development of fluorescent probes for cancer cell imaging
Basic and experimental research
Molecular biology of the inner ear
Molecular biology of pharyngeal cancer
Molecular biology of differentiation and development of inner ear and olfactory epithelium
Origins of vestibular myogenic potential
Aging and regeneration of olfactory epithelium, pathogenesis of chronic sinusitis and allergic
rhinitis
Physiology of vocal cord vibration, Molecular biology of recurrent laryngeal papillomatosis
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Rehabilitation Medicine
Our research purpose is to elucidate the causalities between the pathology
of diseases and the limitation of activities and social participation of thepatients. The findings from that research would lead to the improvementof physical activities of people with disabilities.
Topics● Clinical research for congenital limb deficiency● Health promotion for people with chronic disabilities● Evaluation and intervention for dysphagia● Image analysis for bone metastasis

Anesthesiology(TXLYDOHQWVWUHVVVZDOORZLQJYLGHRIOXRURJUDSK\ IRUFHUYLFDOVSRQG\ORVLV

https://www.ut-anes.org/

We have seven research groups and their fields include respiratory,
cardiovascular, pain, nervous, and immune systems.Our ongoing andrecent major research subjects are:Respiratory system – A role of cytokine signaling in acute lung injury;
Transpulmonary pressure during mechanical ventilation; Exploring risk
factors of perioperative exacerbation of interstitial lung disease;● Immune system – Modification of immune system by anesthesia;
Apoptotic signal transduction induced by sepsis or ischemia-reperfusion
injury;● Pain – A role of lipid mediators in the formation of hyperalgesia; A role ofspinal microglial cells in the development of inflammation-mediatedneuropathic pain; Cognitive-behavioral therapy on chronic pain;
Clinical Practice and Research of Anesthesiology● Nervous system – Analysis of electroencephalography during generalanesthesia; Exploring relationship between postoperative delirium and bloodbrain barrier dysfunction;● Metabolism – Clinical significance of fatty acid metabolites in general anesthesia;● Cardiovascular system – Retrospective analyses on perioperative management of left ventricular assisting device
implantation or heart transplantation; Physiology and molecular biology of left/right heart failure of animal models;● Medical device – Invention and validation of new anesthetic procedures with emerging technologies;● Epidemiological survey and outcome study with large administrative database.
●40

Acute Medicine

https://www.tokyodam.com/

We, acute care physicians, have a role to treat the patients with sudden and unexpected illness and injury, and our
specialties are very wide in the settings of prehospital, disaster, ER (emergency room), and critical care. Acute Medicine is
the science of these fields. Main studies of our department are as follows.
Acuity of injury and illness related studies●●

Establishment of conception of "definitive acuity"
Acuity and severity scoring system

Methodology of task switching in the setting of multitask at ER● Improvement of outcome of emergency patients by mobile on-site
physicians team
● Performance indicators of medical control for paramedics● Performance indicators of regional emergency medical service system● Critical care related studies

Research Field of Acute Medicine●●Versatile and durable WEB-based information sharing system for emergency
medical service system and disaster medical response.
● Mass casualty incident and natural disaster medical response related studies
●

●
●

Preh

Relationship between biomarkers and severity of critically illness
Non invasive monitoring technology to predict circulatory shock statusospit
Disa al care mster
med edicine
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●

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Investigation of regional disaster medical risk-resource-ratio (static approach)
Dynamic simulation model of necessity of regional medical resource in MCI and large scale natural disaster

41

Health Sciences and Nursing

Mental Health / Psychiatric Nursing

http://plaza.umin.ac.jp/heart/

Our departments conduct research on mental health and psycho-social
stress and provide education/ training of professionals in related fields
from global perspectives.
●

Mental Health
●
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Mental health epidemiology
Occupational mental health/Occupational health psychology
Internet-based Cognitive Behavioral Therapy
Perinatal Mental Health
Disaster and mental health
Global mental health

Psychiatric Nursing●●●●

Supporting people living with mental health problems
Wellness self-management in mental health
Recovery for people with mental illness
Peer support

Biostatistics / Epidemiology and Preventive Health Sciences

http://www.epistat.m.u-tokyo.ac.jp/

We are working on methodological researches of biostatistics andtheoretical epidemiology, as well as consulting and supporting the
conduct of epidemiologic/clinical studies. The followings are ourimportant missions: statistics education for undergraduate and graduate
students; the support of planning and analysis for clinical trials
conducted in the University of Tokyo Hospital Clinical Research Promotion
Center; and the support of resource development for academic
biostatisticians.
●

Methodology
●
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Design and analysis of clinical trials/epidemiologic studies
Statistical analysis of real-world data
Causal inference, missing data analysis and meta-analysis

Collaborative projects
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42

Research for the Construction of Trial Ready Cohort on preclinical andprodromal dementia (J-TRC)
Global Advanced/Adjuvant Stomach Tumor Research through International
Collaboration (GASTRIC): individual patient data based meta-analyses for
gastric cancer
Japan Environmental and Children's Study (JECS)

What is a causal effect? Biostatistics provides the means tocausal inference from observed data.

Nursing Administration / Advanced Clinical Nursing

http://nurs-adm.umin.jp/

We aim to develop systems and methodology to bring out the potential ofnursing and healthcare organizations to contribute well-being of not only
patients, but also workers and institutes, and society. With this aim, we try
to elucidate complex organizational phenomena, and to find keys toeffective organizational development, while tackling to develop the
methodology for organizational researches.
Organizational process/management process
Work environment● Methodology for understanding phenomena in nursing
organization●●

Family Nursing
Hand-in-hand with the seismic social changes occurring nationally andworldwide -- including declining birthrates and a growing proportion of elderly
people, vulnerability of regional networks, and movement toward a genderequal society -- the form and function of the family unit are also changing.
Current Japanese society expects not only a client-centered perspective, butalso a perspective of the family as 'client' in nursing research. Within thiscontext, our research focuses especially on child-rearing issues and on caring
for children with illness.
Postnatal depression, difficulties in child rearing, child abuse and neglect
Development of Pediatric QOL Inventory for children with chronic illness and theirparents● Transitional care for children, adolescent and young adult with childhood-onset
chronic diseases and their families● Support for survivors of childhood cancer including caring of their late effects,
special needs education, school reentry and working● Multidisciplinary collaboration for families and communities● Burden borne by caregivers of children with medical complexity, and their utilizationof respite care services● Care for dying patients and their families (QOL, family function)●●

Community Health Nursing

http://park.itc.u-tokyo.ac.jp/chn/english/index.html

The goal of our department is to continuously maintain and improve thehealth and quality of life of people regardless of their life stages andhealth statuses, by taking advantage of the characteristics of a target
community or population and constructing the system. Also, we cover
the research on skills of public health nurses who are the provider ofcommunity health care.
●
●

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Construction of community health care system
Community health care for mothers and children, adults, older people,
and mental disorders

Assessing community’s characteristics for Community Diagnoses

Community health nursing for disaster prevention and recovery
Skills of public health nurses

Health education program for older people

43Gerontological Home Care and Long-term Care Nursing/ Palliative Care Nursing
http://www.adng.m.u-tokyo.ac.jp

Our research activities are targeted at quality assurance/
improvement of long-term nursing care for clients and theirfamily members. We also aim at advancing knowledge groundedat nursing activities in Japan. 1) Developing theoreticalframeworks that guide nursing care by explaining the nature ofillness/aging experience and experience of taking care of others.
2) Developing quality improvement systems for nursing/healthcare in hospitals, long-term care facilities, outpatients, andhome care.
Quality assurance/improvement of care in the long-term caresystem● Development of clinically derived theories through case studies
and phenomenological approach● Development of a community care system and nursing role
● Development of quality indicators for long-term care
● Development of IT-based nursing care/educational programs●

Hosted workshops for community-building using a gaming toolMidwifery and Women's Health

http://midwifery.m.u-tokyo.ac.jp/en/

The physical and psychological changes that occur during the perinatal period have a critical influence on women’s lifelong
health. Additionally, this influence extends to their children, families, and communities. Our department specially focuseson the health of mothers and children in the perinatal period and mainly performs research in the following areas:●

Creating evidence of health guidance during pregnancy●●

Development of a support system for reliable childbirth
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Pelvic floor disorders among postpartum women
Risk factors of mastitis and breast abscess among postpartum womenDevelopment of a support system for women’s health●●●Midwifery care for positive childbirth experiences
Addressing ‘Fear of childbirth’ and psychosocial factors among pregnant Japanese womenDevelopment of assessment methods of birth canal using transperineal ultrasonography
Development of the strategy for safe delivery in El Salvador
Evaluating care in-hospital midwife-led system and in-hospital midwifery clinic
Evaluation of learning efficacy of Virtual Reality on midwifery education: Collaborative research
between Japan, Australia, and New Zealand

Development of a support system for postpartum body management●●

Healthy lifestyle: adequate maternal nutrition, weight management, exercise, physical activity,
sleep, and mental healthSupport for health of working mothers and women
Preconception care

Creative evidence of health guidance for neonatal skin care●●

Development of an effective skin care intervention to prevent neonatal skin problems
Changes in neonatal skin barrier function and skin resident microflora by skin care

Gerontological Nursing / Wound Care Management

Drawing / Shoichi Sakamoto

http://www.rounenkango.m.u-tokyo.ac.jp/
index-e.html

With the aim of creating a society in which people feel that growing old is not a bad thing, the mission of our department is to (1)realize a care situation that does not force people to suffer, and (2) establish new nursing care technologies for medical patients
who are unable to express their suffering. Our research is based on the method of reverse translational research, in which themechanisms of clinical issues to be addressed by nursing science are investigatedthrough basic research (e.g., biological science), devices are developed to intervenein the identified targets (e.g., engineering), and the technologies and systems areevaluated in clinical practice to identify new issues. Based on these methods, we are
implementing "nursing science and engineering" to develop and disseminate noninvasive, non-constraining, real-time nursing technologies and devices.
Elucidation of the pathogenesis of hard-to-heal wounds and development ofmanagement technologies● Development of next-generation nursing care using artificial intelligence● Search for biomarkers that reflect skin conditions● Verification of effectiveness regarding the use of robot technology for home
visit services● Development of technology for early detection and prevention of extravascularleakage of intravenous fluids● Utilization of ultrasound technology to support feeding, swallowing, andelimination●

44

Products developed through reverse translational researchHealth Sciences and Nursing
Health Sociology See Health and Social Behavior(p50)
Health Education See Health and Social Behavior(p50)
Biomedical Ethics See Biomedical Ethics(p51)45International Health

Global Health Policy

http://www.ghp.m.u-tokyo.ac.jp

Our mission is to improve population health by enhancing accountability and improving the evidence base of global (bothdomestic and international) health programs through the provision of the best possible information and rigorous
monitoring and evaluation. The department's members generate knowledge and ideas through their research with highsocial and academic impacts, strengthen technical and leadership skills through educational programs, and enhancenational capacities through collaborative projects, especially in the developing world.
The priority areas of research are:
● Global Burden of Disease (GBD)● Health System Performance Assessment● Domestic Health Policy Reform● Inequality and Inequity in Health● Health impact of climate change● Environmental epidemiology● Health Technology Assessment and Health Innovations● Radiation Exposure and Health in Fukushima

Community and Global Health
Global health is about achieving equity, social justice, and narrowing
unacceptable health gaps globally. To achieve this, all countries and people
should share their experience and wisdom to help people have control
over and improve their health and well-being. In other words, ending
global health itself is the goal of global health. Our department conducts
research in the following areas:
Health, nutrition, and development
Health, human rights, and human security● Infectious disease control (malaria, TB, HIV, NTDs, etc.)● Health promotion (in particular, health literacy)● Disaster and health● Human resources for health● Maternal, newborn, and child health● Implementation research● Positive deviance approach●●46

http://www.ich.m.u-tokyo.ac.jp/en/index.html

Human Genetics

http://www.humgenet.m.u-tokyo.ac.jp/index.en.html

Human Genetics is a field focusing on the diversity of the human genome, and can include studies into the molecularmechanisms of genetics, evolutionary history of homo sapiens, cancer genome, as well as susceptibility genes forcommon and rare diseases. The findings of such genetic studies have proven useful in many applications, from supporting
clinical diagnosis of diseases to drug development and therapy. Recent advancements in genomic analyses have allowed
us to obtain enormous amounts of genetic and transcriptomic data. Such data will continue to grow in size and utilization
in society, reflecting the increasing importance of the field of human genetics.

Developmental Medical Sciences

http://www.development.m.u-tokyo.ac.jp

Founded in 1966 as the Department of Maternal and Child Health, this department has devoted itself to the research and前回掲載原稿
前回掲載原稿
前回掲載原稿
educationon the maintenance and promotionof mothers' and children's
health. At present, the main research activities areexperimental and epidemiological
studies on the etiology (genetic and environmental factors),
pathogenesis, prevention andtreatmentofviral
infections
andchildhoodbrain
disorders(congenitalandacquired)
that
cause
mental082
発達医科学
082and motor disabilities
発達医科学
082
発達医科学
and epilepsy, from the standpoints of international health science, virology and developmental neuroscience.

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学

Developmental
Medical Sciences 発達医科学
45

45Medical Sciences
Developmental

Developmental
Medical Sciences 発達医科学
45
発達医科学#

Molecular epidemiology of infectious diseases
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関する研究
発達期脳障害に関する研究
発達期脳障害に関する研究● Studies
浮腫）
急性脳症（脳浮腫）
急性脳症（脳浮腫）
on developmental brain disorders
using genetically（シグナル伝達異常）
結節性硬化症（シグナル伝達異常）
結節性硬化症（シグナル伝達異常）
engineered miceett 症候群（シナプス機能異常）
てんかん、Rett 症候群（シナプス機能異常）

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母子保健学教室として 1966 年に設立され、母子の健康の維持増進
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主として発達障害（知的障害・運動障害）やてんってきた。現在は主として発達障害（知的障害・運動障害）やてんってきた。現在は主として発達障害（知的障害・運動障害）やてんってきた。現在は主として発達障害（知的障害・運動障害）やてん●期脳障害（先天性および後天性）の病因（遺伝おかんをきたす小児期脳障害（先天性および後天性）の病因（遺伝おかんをきたす小児期脳障害（先天性および後天性）の病因（遺伝おかんをきたす小児期脳障害（先天性および後天性）の病因（遺伝お●
予防・治療に関する研究を、国際保健学・発達神
よび環境）
・病態・予防・治療に関する研究を、国際保健学・発達神
よび環境）・病態・予防・治療に関する研究を、国際保健学・発達神
よび環境）・病態・予防・治療に関する研究を、国際保健学・発達神
実験的・調査的手法を用いて進めている。
経科学の立場から、実験的・調査的手法を用いて進めている。
経科学の立場から、実験的・調査的手法を用いて進めている。
経科学の立場から、実験的・調査的手法を用いて進めている。
●
●

●

●

●

●

●

●

（低酸素、虚血）●学的研究

てんかん、Rett 症候群（シナプス機能異常）
周産期脳障害（低酸素、虚血）

●

●

●

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下痢症ウイルス
ヘルペス属ウイルス

母子の健康に関する疫学調査●●●

Epidemiological and132
clinical studies on maternal andchild health132↑ 印刷範囲てんかん、Rett 症候群（シナプス機能異常）
周産期脳障害（低酸素、虚血）!"#$%&'()*+,-.,*.&')/0'-()&1/2+,&34*()& 52)06(/)*7&0/)),06(8(69&1*:
感染症の分子疫学的研究
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する疫学調査

●

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ス
イルス

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CDKL5 (Cyclin-dependent kinase-like 5)周産期脳障害（低酸素、虚血）
deficiency disorder!"#$%  %

感染症の分子疫学的研究(developmental
epileptic
encephalopathy):elucidatemolecular
感染症の分子疫学的研究
下痢症ウイルス下痢症ウイルス
pathomechanisms
and therapeutics
ヘルペス属ウイルスヘルペス属ウイルスCure
neurodevelopmental disorders 母子の健康に関する疫学調査
by inducing brain plasticity
母子の健康に関する疫学調査
栄養障害
栄養障害
Tuberous
Sclerosis
新生児医療
新生児医療
●

●

栄養障害
新生児医療
↑ 印刷範囲↑ 印刷範囲↑ 印刷範囲CDKL5 deficiency
connectivity
al Medical Sciences Developmental
Developmental
Medical Sciences Developmental Medical Sciences
Medicaldisorder:
Sciences brain functional
Neonatal
the Department of Maternal and Child
Health,this ascareFounded
Health,this as the Department of Maternal and Child Health, thisFoundedin 1966
the Department of Maternal and Child Health,thisin 1966 as the Department of Maternal and Child
Foundedin 1966●●

voted itself to the research and educationon hasthe devoted itself to the research and education
department
on hasthe devoted itself to the research and education on thedepartment
on the has devoted itself to the research and education
department
promotion of mothers' and children's
health,maintenanceand promotion of mothers' and children's
health,maintenanceand promotion of mothers' and children's
health,maintenanceand promotion of mothers' and children's health,f infectious diseases, nutritionalincluding
disordersstudies
and of infectious diseases, nutritional disorders
includingdisordersstudies
and of infectious diseases, nutritional disorders andand studies of infectious diseases, nutritionalincluding
es. At present, the main research
activitiesanomalies.
arecongenital
activitiesanomalies.
arecongenital
At present, the main research activities
are anomalies. At present, the main researchcongenital
At present, the main research activities are
pidemiological studies on the etiology(genetic andexperimental
and epidemiological studies on the etiology(genetic andexperimental
and epidemiological studies on the etiology (genetic
andexperimental
and epidemiological studies on the etiology (genetic andors), pathogenesis, prevention andtreatment offactors), pathogenesis, prevention and treatment
environmental
factors), pathogenesis, prevention andtreatment offactors), pathogenesis, prevention and treatment ofenvironmentalofenvironmental
rain disorders (congenital and acquired)
that
cause
variouschildhoodbrain
disorders(congenitalandacquired)
that
cause
various childhood brain disorders (congenital and acquired) that cause
various childhood brain disorders (congenital and acquired) that cause
disabilities and epilepsy, from theviewpointofmental ofand motor disabilities and epilepsy, from theviewpointofmentaland motor
disabilities and epilepsy, from the viewpoint
mentaland motor
disabilities and epilepsy, from the viewpoint ofscience and developmental neuroscience.
international health science and developmental neuroscience.international health science and developmental neuroscience.
international health science and developmental neuroscience.
● Studies on developmental brain disorders
opmental brain disorders● Studies on developmental brain disorders● Studies on developmental brain disorders

http://www.humeco.m.u-tokyo.ac.jp/en/

Human Ecology

The field of human ecology encompasses a wide range of perspectives inan effort toAcuteunderstandhealth in relation
to adaptation
to physicalAcute encephalopathy(brain edema)
encephalopathy (brainhumanedema)
Acute encephalopathy (brain edema)
Tuberous sclerosis (abnormal signal transduction)
Tuberous sclerosis (abnormal signal transduction)
Tuberous sclerosis (abnormal signal transduction)
Epilepsy,
Rett syndrome (abnormal synaptic
function)
Epilepsy, Rett syndrome (abnormal
Epilepsy,and social environments.
Tosynaptic
thisfunction)
end, we use
methodologies
developed
in Rett syndrome (abnormal synaptic function)
Perinatal brain injury (hypoxia, ischemia)
Perinatal brain injury (hypoxia, ischemia)
Perinatal brain injury (hypoxia, ischemia)
miology of infectious diseases
Molecular
epidemiologyofinfectious
diseases
Molecular
epidemiologyofinfectious
diseases
Molecular
epidemiology of infectious diseases
human biology,
nutritional
sciences,
anthropology,
demography,
es
Diarrhea
viruses
Diarrhea viruses
Diarrhea virusess
Herpesviruses
Herpesviruses
Herpesviruses
environmental
health, and urban ecology.
The major
topicsof our studies
maternal and child health
Epidemiology
of maternal andchild health
Epidemiology of maternal and child health
Epidemiology of maternal and child health
Malnutrition
Malnutrition
icine
Perinatal medicine
include: Malnutrition
Perinatal medicine
Perinatal medicine

halopathy (brain edema)rosis (abnormal signal transduction)
syndrome (abnormal synaptic function)n injury (hypoxia, ischemia)

●

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●

↑ 印刷範囲●↑ 印刷範囲↑ 印刷範囲↑ 印刷範囲

）（教授、准教授のみ掲載されます。
）
ッフ（教授、准教授のみ掲載されます。
分野名・スタッフ（教授、准教授のみ掲載されます。
）（教授、准教授のみ掲載されます。）
分野名・スタッフ
分野名・スタッフ●

輝幸

Health impact of exposure to heavy metals, air pollution, unhealthy urban
英文表記
和文表記
英文表記
和文表記
英文表記
和文表記
structures,and ecosystem degradation;
Developmental
MedicalSciences
Developmental
Medical Sciences
発達医科学
Developmental
Medical Sciences
発達医科学
発達医科学
● The
roles ofProfessor
gut microbiota
in nutritional
adaptationand the evolutionofTeruyuki Tanaka
Teruyuki Tanaka
准教授
田中 輝幸
Associate Professor
Teruyuki Tanaka
准教授Associate
田中 輝幸
准教授Associate
田中Professor
輝幸
human
populations;● Mitigation of the health impacts of aging and depopulation at community/
national scales;● Biological and behavioral explanations of low fertility and fecundity during
the post-demographic transition period;
82
82● Interaction among subsistence, nutrition and health; and● Medical anthropology; ecological anthropology.

英文表記

A community
in Laos.
Developmental Medical Sciences
Associate Professor

Teruyuki Tanaka

82

82

Rice terraces in West Java, Indonesia.

47

Biomedical Chemistry
Our major research interests include virulence mechanisms and metabolism
of protozoa, particularly Plasmodium spp. causing malaria and Entamoeba
histolytica causing amebic dysentery. We mainly focus on vesiculartrafficking, phagocytosis, autophagy, proteases, amino acid metabolisms,
RNA maturation, translation, drug development, and organellogenesis. Our
research approaches are very robust, and include biochemistry, molecularand cell biology, live imaging, multi-omics including metabolomics, andreverse genetics. Our present research themes include:
Molecular elucidation of pathogenesis of parasites
Biochemical and biological analyses of metabolism and organelles unique toparasites● Analysis of vesicular traffic, protein secretion, and phagocytosis/trogocytosis
in parasites● Genome wide analysis and comparison of parasite strains● Drug discovery and development against protozoan infections such as
malaria and amebiasis● Elucidation of divergence of RNA maturation and translation●●

Entamoeba histolytica eating human cells

School of Public Health
Biostatistics See Biostatistics / Epidemiology and Preventive Health Sciences(p42)
Health Sociology and Health Education See Health and Social Behavior(p50)48

School of Public HealthSocial and Preventive Epidemiology

http://www.nutrepi.m.u-tokyo.ac.jp/

Our main research field is preventive epidemiology onlifestyle-related diseases. This department is unique inJapan since our core research field is "nutritional
epidemiology", which epidemiologically examines theroles of diets for disease prevention and control.
Methodological studies on dietary assessments
Nutritional epidemiologic studies on nutrient intakes/
dietary
behaviors and health status● Studies on development of dietary promotion methods
andevaluation of their effectiveness● Establishment of literature database for "epidemiologic
studies on diets and health"● Collaborative studies on nutrition with local govements,
research groups on public health, those on clinicalresearches, and others.
●●

Clinical Epidemiology and Health Economics
Through the cooperation with the specialists of
epidemiology, statistics, clinical medicine, and economics,
we implement multidisciplinary studies on clinicalepidemiology, health economics, health technology
assessment and health policy using large healthcare
databases.
Clinical epidemiological studies using the Diagnosis
Procedure Combination database● Health economics and policy studies using thegovernmental statistics● Application of statistical methods for observational
studies● Integration of multiple databases●49

Health Communication

https://www.umin.ac.jp/hc/index.html

We are developing empirical research on a wide range of communication
types at various levels in the field of health communication studies. These
range from interpersonal communication to media communication. Amonglaboratories in Japan focused on health communication studies, we have themost publications, research funds, faculty members, and graduate students.
Our research areas include:● Communication for supporting health-care consumers’ behavioral change● Decision-making by health-care consumers● Media information’s impact on health-care consumers● Online health information● Health literacy● Patient-provider communication

Mental Health

http://plaza.umin.ac.jp/heart/

The Department of Mental Health has engaged in education andresearch on a wide range of topics related to mental health, such associal determinants of stress and mental health. The Departmentp r ov i d e s c l a s s e s o f M e n t a l H e a l t h I ( e p i d e m i o l o g y a n dcountermeasures in mental health) and Mental Health II (occupational
mental health).
Community-based mental health epidemiology
Occupational mental health● Internet-based Cognitive Behavioral Therapy● Perinatal Mental Health● Trauma-Informed Care
● Disaster and mental health● Global mental health●●

Health and Social Behavior
The unit follows the legend of former departments of health sociology,
health education, and social gerontology, and extends its academic
endeavor to empirically reveal complex mechanisms between social
structure/relationship and individual health/behavior. Throughinterdisciplinary and global communication with social science andhealth science, the unit aims at exploring research and education onsocial determinants of health, such as;Trans-generational health impact of socioeconomic status
Health impact of retirement and social participation among the elderly● Policy intervention design to alleviate social exclusion● The impact of healthcare systems for health equity● Social experiences of chronically ills and their health●●

50

The UNU-IIGH/UNDESA/the University of Tokyo Expert Meeting on
Mental Well-being, Disability, and Development in Kuala Lumpur,
Malaysia, April 2013

Biomedical Ethics

http://www.ethps.m.u-tokyo.ac.jp/

The Department of Biomedical Ethics conducts both theoreticaland empirical studies in the fields of biomedical ethics,
research ethics and clinical ethics. Research topics include
ethical theories, informed consent, ethics committees andorgan transplantation. The Bioethics Collaborative Research
Organization was recently set up as an adjunct to the
Department of Biomedical Ethics. (https://bicro.u-tokyo.ac.jp/)
Study of the functions and responsibilities of ethics committees inJapan● Study of the methods for the formation of social consensus related
to advanced medical technology● Comparative study of clinical ethics in the Asian region● Study of ethical aspects in neuroscience researches● Ethics in Public Health Emergencies● Psychosocial and ethical aspects of living related organtransplantation●

Health Policy

Researchers from all over the world frequently visit our centerfor joint researches and active discussions.

http://publichealth.m.u-tokyo.ac.jp/

Health Policy is the academic fields in whichscientific evidence is collected, established,accumulated, and disseminated for healthpolicy making. Through studies in various
aspects in health policy, our department aims
t o a d v a n c e r e s e a r ch , s u p p o r t p o l i c ydevelopment, and promote education toward
these ends. This department is concurrently
operated with Department of Public Health.
Efficiency and equity issues of health systems
Health manpower policy● Occupational and environmental epidemiology● Health services research●●International comparison of age-standardized cause-specific mortality rateby occupational class among men aged 35-64

Healthcare Informatics

http://www.m.u-tokyo.ac.jp/medinfo/

The Department of Biomedical Informatics aims to reform medical
systems and make social contribution by applying information
technology to medical and clinical field including hospital
information management. The department develops innovative
methods that are applicable to medical information systems in theboundary area of healthcare and information science, establishes
infrastructures for information environment, and applies knowledge
and technique acquired through these efforts to medical andhealthcare field.
The main keywords of the target domain are medical and clinicalinformation systems, next-generation electronic health record
systems, virtual health care environment, mobile health, and AI
including natural language processing as well as machine learning.
Automatic Mapping from Clinical Case Dara toDevelopment and application of clinical ontology
Knowledge of Disease Transition● Research for sharing healthcare data among medical institutions
and hospitals, and the application for clinical epidemiology● Extraction of medical knowledge from electronic medical record database using natural language processing● Development of knowledge-driven real time alerting system in clinical practice● R&D of medical artificial Intelligence and mobile healthcare system●

51

Clinical Information Engineering

http://webpark1893.sakura.ne.jp/wp/researches/

Clinical Information Engineering focuses on computer applications
that address biomedical data (collection, analysis, representation). It
is a combination of information science, computer science, andclinical science designed to assist in the management and processingof data, information and knowledge to support the practice anddelivery of clinical care and public health.
ClinVR: Clinical Interactive 3D Computer Graphics & Virtual reality
PHI: Social information engineering for Public Health (Public Health
Informatics: GIS for Health Science etc.)● Elucidation of the medical effects of virtual experiences on thehuman body (VR medicine)●●

Forensic Medicine

http://ut-forensic.jp

We conduct autopsies, and various examinations including histology,
biochemistry, radiology, toxicology, and genetics as usual practices. We also
perform the following research with other institutes and departments
including Education and Research Center of Legal Medicine, Chiba University,and Department of Forensic Medicine, School of Medicine, International
University of Health and Welfare.
Application of imaging modalities such as CT and MRI for death investigation
Age and stature estimation and sex
determination using CT● Biomechanical properties of human tissue● Diagnosis of drowning● Research for infectivity of SARS-CoV-2 indecedents● Analysis and pathophysiology of illegal drugs
including new psychoactive substances● Application of relatively new DNA testing
method for practice of forensic medicine●●

Global Environmental Health
The Department of Global Environmental Health (GEH) aims
to study the relationships between the environment andhuman health and to produce well-educated professionals
with the ability to undertake epidemiological research. Our
research interest includes climate change and variability, air
pollution, and human health across multiple countries inenvironmental epidemiology. We address the scientificquestions about how the environmental stressors areassociated with health outcomes and potential socioeconomic determinants that modify the exposure-response
associations. The GEH provides two courses, 1) Environmental
Health and 2) Methods for Environmental Health Research.
Health risk assessment of climate change and air pollution
Seasonality of suicide and the short-term associations between suicideand atmospheric environmental factors based on a large-scale
database of the multi-city multi-country (MCC) network● Development of a statistical prediction model for malaria early warning
systems in Southern Africa●●

52

Forensic autopsy room

CT roomhttps://sites.google.com/m.u-tokyo.ac.jp/envhealth

Geographical distribution of the MCC network
for the suicide-temperature association study

Center for
Disease Biology and Integrative Medicine

Molecular Biomedicine for Pathogenesis
A variety of biological garbage such as necrotic cells, cancerous cells,
excess lipids, or degenerated cells and proteins, are constitutively
developed in our body. Such undesired substances are usuallyeliminated quickly, which is followed by tissue regeneration.
Abrogation of such "removal system" may cause accumulation of
garbage in tissues, accompanied by the secondary inflammation andfibrosis, resulting in the development of types of diseases. Thus, thisscavenging response is essential to maintain the body in homeostasisand healthy state. Our overall goal is to apply our findings to develop
a novel therapy based on this system against diseases.

http://tmlab.m.u-tokyo.ac.jp/english/index.html
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Elucidation of molecular mechanism of "removal system"
conducted by serum protein AIM.
● Comprehension of diseases caused by abrogation of this removal
system: acute kidney injury, chronic kidney disease, cancer,
obesity, neurodegenerative diseases, autoimmune diseases,
aging, etc.
● Development of novel therapies against diseases.

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http://www.bm2.m.u-tokyo.ac.jp/index-e.html

Structual Physiology
We have been exploring two-photon excitation microscopy, which
utilizes an infrared femtosecond-pulsed laser as a light source, tovisualize and stimulate intact tissues at the cellular and molecularlevels. We focus on the functions and disorders of the brain andsecretory organs.
The dynamics of synapses in the cerebral cortex, in relation tomemory, cognitive processes and mental disorders● Molecular mechanisms of exocytosis in synapses and the islet of
Langerhans, and their optical control●

Fine structure and function of a central neuron studied
with two-photon excitation imaging and uncaging

53

Biomedical Equipment and Biomaterial

http://www.cdbim.m.u-tokyo.ac.jp/

We aim to create a basic methodology for research and development of new
biomedical equipment and biomaterial applicable clinical site by integrating
bioengineering technology such as mechanical, measurement, material andchemical engineering. For biomaterial, we develop new biocompatiblehydrogels based on polysaccharides, hyperbranched polymers, and DNA
analogues, which materials are applied to drug delivery systems for peritoneal
diseases, artificial red blood cells, and artificial pancreas islets. In research of
medical equipment, robot-assisted technologies are studied to promote
medicine-engineering collaboration. Targets of our robotic applications include
microsurgery, minimally invasive surgery, pathological examination andscience experiments.
Fabrication of new biocompatible hydrogels and particles
Development of anti-peritoneal adhesion barrier, hemostats● Drug delivery for peritoneal diseases, mesothelioma, liver cirrhosis, scleroderma● Medical robots and their intelligent control● Quantitative surgical skill assessment and its applications●●

Clinical Biotechnology

https://gel.tokyo/med/

Our mission is to establish therapeutic strategies for skeletal
disorders based on understanding of mechanisms underlying
skeletal development, skeletal metabolism and pathology ofskeletal disorders. We explore data-driven studies by omics
analysis focusing on epigenome. By integrating withbioengineering, we apply the study for modeling of tissue
development, establishment of platform for drug discovery andachievement of regenerative medicine.
Identifying dynamics of epigenome and gene regulation inskeletal development and repair by utilizing omics analysis andbioinformatics● Development of screening tools for identifying mechanisms
underlying skeletal development and pathology of skeletal
tissues.
● Modeling human skeletal development of disorders by utilizing
pluripotent stem cells● Development of implant devices for tissue regeneration by
integrating high-performance biomaterials and signaling
molecules stimulating tissue repairing processes.
●

Environmental and Metabolic Health Sciences
Lipids serve as the largest energy source, cell membrane components,
and bioactive mediators. Lipids are major environmental substances
supplied as nutrients and spatiotemporally regulate a variety of
biological responses in response to given microenvironmental cues
within tissues. Our research focuses on the regulation of biologicalnetworks driven by lipids and their metabolites. By taking advantagesof an array of gene-manipulated mice for lipid-metabolizing enzymes
and receptors, we aim to clarify novel lipid-orchestrated mechanisms
underlying various diseases such as metabolic and immune
disorders. Knowledges obtained from these approaches will betranslated to humans toward discovery of new biomarkers or
druggable targets.

54

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;хϳϬŐĞŶĞƐ䠅.QRFNRXWPLFH/LSLGRPLFV'LVHDVHV8QGHUVWDQGLQJRIVSDWLRWHPSRUDOOLSLGIORZVLQKHDOWKDQGGLVHDVHV'LVFRYHU\RIQRYHOOLSLGSDWKZD\VWKDWDUHOLQNHGWRELRORJLFDOSURFHVVHVAnimal Resources / Research Resources and Support - Animal Research
Our laboratory focuses on understanding the molecular mechanisms
which underlie the brain function and cancer metastasis. We also try
to establish animal models for human psychiatric disorders bygenerating KO mice and marmosets. We also manage the animal
facilities, provide reproductive technology service, advice on animal
experiments, and give lectures on laboratory animals so that animal
experiments are carried out in accordance with animal welfare.
Molecular analysis of brain function and cancer using geneticallymodified mice
● Development of new model animals for psychiatric disorders● Development of gene targeting animals using CRISPR/Cas system●

A mutant mouse lacking metabotropic glutamate receptor
subtype-1 (mGluR1)

Molecular Radiology / Reserch Resources and Suport-Radiation Biology
We are investigating the molecular mechanisms of DNA double-strand
break repair as the scientific basis of radiation therapy andchemotherapy in medical oncology. We also promote the basic researchthat contributes to the development of a novel therapeutic strategy byexamining a link of the DNA metabolic network including DNA
replication and cell cycle control with chromosome instability.

http://www.cdbim.m.u-tokyo.ac.jp/
english/index.html

Molecular mechanisms of homologous recombinational repair
Mechanisms of the choice between homologous recombination andnon-homologous end-joining● Molecular mechanisms of DNA rereplication● Mechanisms of the genesis of aneuploidy● Functional analysis of meiotic recombination genes●●

Centrosome fragmentation which may lead to aneuploidy

Biomedical Informatics

http://www.cdbim.m.u-tokyo.ac.jp/english/index.html

The department conducts researches on the development of medical
artificial intelligence systems and their application to clinical practice(i.e., clinical decision support, knowledge discovery from big data, andso on), utilizing the combined approach of medical knowledge
representation, logical reasoning, and machine learning techniques. We
actively collaborates with the department of Medical informatics,
Graduate School of medicine, and the department of Planning,
Information and Management in the University of Tokyo Hopistal, to
conduct those researches using clinical information. Our activities also
include the practical management of information infrastructure to
support medical researches.
Development and application of clinical ontology
Development of clinical decision support systems using logicalreasoning and machine learning● Clinical text analysis and knowledge extraction using natural language
processing● Development of next-generation EHR system●●

Computer System for Biomedical Research

55

The International Research Center
for Medical Education

Department of Medical Education Studies
The mission of the Department of Medical Education Studies
includes the promotion of medical education not only in the Facultyof Medicine, the University of Tokyo but also in the whole country.
This department works on activities of educational practice or
improvement and promotes research related to the medical
education field. In the university, this department offers educational
activities such as clinical clerkship, PBL (problem-based learning),
clinical skill practical training, and the conduction of OSCE (objective
structured clinical examination). Simulation-based training is alsooffered at the Clinical Simulation Center, The University of Tokyo
Hospital.
Clinical Simulation Center

International Cooperation for Medical Education
This is a department that disseminates basic theory on medical/
health professions education domestically and internationally,
thereby improving health care in a broader sense. In particular, ourstrengths include learner assessment, program evaluation, clinicalreasoning/ clinical decision making, general practice/ family
medicine/ primary care, health communication, and patient-healthprovider relationship. In addition, we are involved in human resource
development in the field of health care and its international
cooperation, and support projects related to medical/ healthprofessions education in Japan and overseas.

One scene of a faculty development workshop

56

Global Nursing Research Center

Division of Care Innovation
With a falling birthrate and a super-aging society, Japan is in need of a paradigm shift that will move it away from a ‘medicalcare that cures’ toward a ‘Medical and nursing care that supports.’ In such a situation, nursing science that plays a key role of‘care’ is expected to foster different field interdisciplinary research / educational environment aiming to nurture young
nursing researchers who can lead care innovation. In our department, with bio-scientist/engineering researchers andcompanies, we aim to develop and care products that reduce inconvenience of daily life due to the health impairment of each
person, accept young researchers and establish an innovative nursing research fields based on transdisciplinary integration.
●

AI Smart Nursing●●●

Robotics Nursing
●
●

●

●

Development of a evaluation method for skin physiological status by skin blotting
Development of a detecting method of biofilm by wound blotting

Visualized Nursing●●●

Development of robotics technology to realize tele-nursing
Application of AI/AR to support self-learning of nursing skills

Biological Nursing●●

Data collection and development of AI prediction models for health conditions based on sensor
data
Development of an AI-based care recommendation application that visualizes disease states andpresents appropriate care methods

Development of educational program for visualization technology using ultrasonography
Development of automatic measuring tool for bladder urine volume

Clinical Nursing Technology●●

Development of nursing technology for early detection of extravasation using the thermo-sensitive
liquid crystal film
Elucidation of the mechanism of infiltration and extravasation

Division of Nursing System
We promote research activities with the aim of ‘providing nursing practice solutions that reflect important cultural andsocial concerns, constructing Japan-origin nursing theories that support high quality practices, and making policy
proposals.’ Health Quality and Outcome Research department contributes to developing a methodology to evaluate theirhealth quality well, conducting studies using outcomes from theirperspectives, and then finally creating new effective and optimized
nursing systems in order to improve the total of quality of life and healthquality among. At the Department of Care Quality Management, we
explore new research methodologies/innovations of research for carequality assurance and continuous quality improvement system.
●

Health Quality and Outcome Research
●
●
●
●

●

Practice and evaluate nursing care directly or indirectly
Deploy research using patient-reported outcomes
Explore new health quality indicator
Develop evaluation methodologies to understand health quality among
overall family and nursing system wellCare Quality Management●●●●

Knowledge development in caring practice
Support for care workers
Care quality assurance in community care system
Development of quality indicators and benchmarking

57

Center for Diversity in Medical Education and ResearchCenter for Diversity in Medical Education and Research
Patients and people with disabilities are the best designers of health care services. If people with disabilities are able to beproviders of medical care based on their own experiences, it will lead to the realization of patient-centered medical care. The
Center for Diversity in Medical Education and Research aims to improve the quality of medical services through thedissemination and implementation of team medicine that is inclusive of medical staff with disabilities by integrating
medicine, social welfare and disability studies.
●

Education
●

●

●
●

●

●

Introduction of Diversity Education in the Graduate School of Medicine and the Faculty of
Medicine
Development of a barrier-free system for faculty of the Graduate School of Medicine, theFaculty of Medicine, and the University of Tokyo Hospital
Development of a training system for medical staff with disabilities
Improvement of the educational environment for students with disabilities enrolled in the
Graduate School of Medicine and the Faculty of Medicine
Training of peer support workers

Research
●

●
●

●

58

Identification of barriers on the social side by analyzing and creating a database of hospitalduties, research activities, and other tasks
Reform of technical standards and examination of appropriate reasonable accommodations
Examination of the quality of medical care provided by medical personnel with disabilities orwith the same attributes
Examining the impact of diversity education for medical students and residents on reducing
stigma and improving the quality of medical careInstitution

Office of International Academic Affairs

http://koryu.m.u-tokyo.ac.jp/

The Office of International Academic Affairs (OIAA) is under the direct authorityof the Dean of the Graduate School of Medicine. The Committee on
International Academic Affairs defines the most important responsibilities of
the OIAA as (1) promoting and facilitating international educational exchange,(2) fostering international exchange among researchers, (3) helping young
researchers excel as scientists and educators, and (4) offering classes on
medical English to, and developing educational materials for, medical students.

Medical Scientist Training Program

http://www.ut-mdres.umin.jp/

Medical Scientist Training Program was launched in 2008, aiming
medical students have the opportunity to experience basic research intheir early years and learn the attitude of a researcher. Students taking
this program will attend extracurricular activities such as journal clubs
and English courses of Medical Research Communications as well as
their own research in labs, retreat and the defense of research honors
theses. Students are also expected to build up a network among
medical students who intend to be a researcher through the programsupport, such as the short term stay at labs abroad, participations to thesymposium, and the excursion with other universities.

59Office for Human Research Studies
Office for Human Research Studies (OHRS) aims to protect the rights, health,and dignity of research participants. Based on this principle, OHRS supports
researchers at the Graduate School of Medicine, the Faculty of Medicine andthe University Hospital to perform their studies in an ethical manner. Our
primary task is the management of the Ethics Committee secretariats.
Additionally, we provide ethics education to researchers through research
ethics seminars, ethics consultations through support of overall medical
writing, and then externally dispatch information on research ethics.

Life Sciences Core FacilityLife Sciences Core Facility provides researchers at the graduate school of
medicine and the faculty of medicine access and technical assistance tospecialized instruments including mass spectrometers, cell sorters, flow
cytometers and a state-of-the-art fluorescent microscope.

The Office for Clinical Practice and Medical Education
The Office for Clinical Practice and Medical Education was established in April
2015 to promote medical education, especially clinical training for the 5th- and6th-year medical students.
We facilitate the clinical clerkship program and establish liaison between
students, faculty and other medical institutions, as well as enhance theclerkship curriculum and evaluation methods.
For individual students, we provide extended support by collaborating with thestudent support office and the educational office of the faculty of medicine.
With the International Research Center for Medical Education and other medical
faculties, we also conduct research on medical education, particularly on therelationship between high-stakes examination and important educational
outcomes, and the relationship between the scores and daily life.

60Medical Libraryhttps://www.lib.m.u-tokyo.ac.jp

The University of Tokyo Medical Library was opened in 1961 as a model of theJapanese modern medical library. The view makes it a perfect place toconcentrate on study.
The library has adopted an open stack system so that users can have directaccess to almost all the materials.
Holdings (as of March 31 2021) :Books(number of volumes) : 274,819 (Japanese 112,470 Foreign 162,349)
Periodicals(number of titles) :3,623 (Japanese 1,681 Foreign 1,942)● Visitors (2020): 1,365*● Borrowed Books (2020): 5,536*●*To deal with COVID-19, our library was open only for 155 days in 2020.

Museum of Health and Medicine

http://mhm.m.u-tokyo.ac.jp/

Museum of Health and Medicine was planned as part of commemorative projects to celebrate the anniversary of thefounding of the Graduate School of Medicine and the University of Tokyo Hospital. Our Museum was opened on Jan. 20th,
2011 and is located in the South Clinical Research Bldg.
The permanent exhibition is a display medical archives and instruments from the early era, such as Ishihara’s Color Blind
Test Charts and the gastrocamera developed at the University. Special exhibitions is planned to promote understanding
among the regarding advances in medical science and health.

61

Ikenohata Gate

Clinical Research
Bldg.(East)

Clinical Research
Bldg.(North)

Molecular &Life Innovation
Bldg.

ClinicalResearch Bldg.A

Clinical Research
Bldg.(West)

ClinicalResearch Ward
Central Bldg. Inpatient(North)Bldg. B
Inpatient
Bldg. A

Central Bldg.
(East)

Central Bldg.
(South)Central Clinical
Service Bldg.1
Central Clinical
Service Bldg.2

Administration Bldg.

Tetsu-mon
Gate

Med.4

Outpatient Clinic
Bldg.

South ClinicalResearch Bldg.

Tatsuokamon Gate

MedicalLibrary

International
ResearchCenterMed.2

Med.5
Bioscience
Reseach Bldg.
Med. Experimental
Research Bldg.

Kasuga Gate

Med.3

Med.1

Main Gate

AkamonGate

Hongo-sanchome Stn.
on Subway Line
: Marunouchi Line: Oh-edo Line

Shigeo Okabe, Dean, Faculty of Medicine, Graduate School of Medicine
The University of Tokyo
Address:7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan
http://www.m.u-tokyo.ac.jp

Issued on May, 2021