November, 2021

業績リスト（藤田健志）

ORCID: https://orcid.org/0000-0001-9666-022X
ResearcherID: http://www.researcherid.com/rid/Q-5564-2017
Google Scholar: https://scholar.google.co.jp/citations?hl=en&user=idjBPJwAAAAJ
researchmap: https://researchmap.jp/7000000999
筑波大学 TRIOS: https://trios.tsukuba.ac.jp/researcher/0000000665<Original Papers>
1) T. Fujita,* R. Morioka, T. Fukuda, N. Suzuki, J. Ichikawa,* “Acid-Mediated Intermolecular
C–F/C–H

Cross-Couplingof2-Fluorobenzofurans

withArenes:Synthesisof2-Arylbenzofurans,” Chem. Commun., 57, 8500–8503 (2021).
2) T. Fujita,* N. Shoji, N. Yoshikawa, J. Ichikawa,* “Helicene synthesis by Brønsted
acid-catalyzed cycloaromatization in HFIP [(CF3)2CHOH],” Beilstein J. Org. Chem., 17,396–403 (2021).
3) T. Fujita, M. Takeishi, J. Ichikawa, “Copper-Catalyzed [3 + 2] Annulation of Azides with a(Difluorovinyl)zinc Complex, Fluoroacetylene Equivalent,” Org. Lett., 22, 9253–9257(2020).
4) R. Morioka, T. Fujita, J. Ichikawa, “Facile Synthesis of 2-Fluorobenzofurans: 5-endo-trigCyclization of β,β-Difluoro-o-hydroxystyrenes,” Helvetica Chim. Acta, 103, e2000159(2020).
5) T. Kubo, T. Fujita, J. Ichikawa, “Nickel-catalyzed [4 + 2] Cycloaddition of Styrenes withArynes via 1:1 Cross-coupling: Synthesis of 9,10-Dihydrophenanthrenes,” Chem. Lett., 49,
264–266 (2020).
6) I. Takahashi, T. Fujita, N. Shoji, J. Ichikawa, “Brønsted acid-catalysed hydroarylation ofunactivated alkynes in a fluoroalcohol–hydrocarbon biphasic system: construction ofphenanthrene frameworks,” Chem. Commun., 55, 9267–9270 (2019). Highlighted as Front
Cover Picture: Chem. Commun., 55, 9219 (2019).
7) T.

Fujita,K.

Ide,T.

3-(Trifluoromethyl)indoles

C.
byJankins,T.

Oxidative

Nojima,J.

Cyclization

Ichikawa,
of“Synthesisofo-Sulfonamido-α-(trifluoromethyl)styrenes,” Asian J. Org. Chem., 8, 637–640 (2019). Highlighted as FrontCover Picture: Asian J. Org. Chem., 8, 564 (2019).
8) T. Fujita, M. Hattori, M. Matsuda, R. Morioka, T. C. Jankins, M. Ikeda, J. Ichikawa,“Nucleophilic 5-endo-trig cyclization of 2-(trifluoromethyl)allylic metal enolates andenamides: Synthesis of tetrahydrofurans and pyrrolidines bearing exo-difluoromethyleneunits,” Tetrahedron, 75, 36–46 (2019).
9) T. Fujita, R. Morioka, T. Arita, J. Ichikawa, “sp3 Carbon–Fluorine Bond Activation in
2,2-Difluorohomoallylic Alcohols via Nucleophilic 5-endo-trig Cyclisation: Synthesis of3-Fluorinated Furan Derivatives,” Chem. Commun., 54, 12938–12941 (2018). Highlighted
as Back Cover Picture: Chem. Commun., 54, 12938 (2018).
10) T. Fujita, N. Konno, Y. Watabe, T. Ichitsuka, A. Nagaki, J. Yoshida, J. Ichikawa, “FlashGeneration and Borylation of 1-(Trifluoromethyl)vinyllithium toward Synthesis ofα-(Trifluoromethyl)styrenes,” J. Fluorine Chem., 207, 72–76 (2018).
11) T. Fujita, R. Kinoshita, T. Takanohashi, N. Suzuki, J. Ichikawa, “Ring-size-selectiveconstruction of fluorine- containing carbocycles via intramolecular iodoarylation of1,1-difluoro-1-alkenes,” Beilstein, J. Org. Chem., 13, 2682–2689 (2017).
12) K. Fuchibe, K. Shigeno, N. Zhao, H. Aihara, R. Akisaka, T. Morikawa, T. Fujita, K.
Yamakawa, T. Shimada, J. Ichikawa, “Pinpoint-fluorinated Polycyclic AromaticHydrocarbons (F-PAHs): Syntheses of Difluorinated Subfamily and Their Properties”, J.
Fluorine Chem., 203, 173–184 (2017).
13) Y. Watabe, K. Kanazawa, T. Fujita, J. Ichikawa, “Nickel-Catalyzed Hydroalkenylation ofAlkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes,” Synthesis, 49,3569–3575 (2017).
14) I. Takahashi, M. Hayashi, T. Fujita, J. Ichikawa, “Brønsted Acid-catalyzed Tandem
Cycloaromatization of Naphthalene-based Bisacetals: Selective Synthesis of ortho-Fused
Six-hexagon Benzenoids,” Chem. Lett., 46, 392–394 (2017).
15) K. Saito, T. Ikeda, Y. Yamamura, H. Saitoh, M. Hishida, Y. Kobayashi, T. Fujita, J.
Ichikawa, “Cell-quintupling: Structural phase transition in a molecular crystal, bis(trans-4–butylcyclohexyl)methanol,” J. Chem. Phys., 146, 074503 (2017).
16) T. Fujita, M. Takazawa, K. Sugiyama, N. Suzuki, J. Ichikawa, “Domino C–F Bond
Activation of the CF3 Group: Synthesis of Fluorinated Dibenzo[a,c][7]annulenes from
2-(Trifluoromethyl)-1-alkenes and 2,2’-Diceriobiaryls,” Org. Lett., 19, 588–591 (2017).

17) T. Fujita, I. Takahashi, M. Hayashi, J. Wang, K. Fuchibe, J. Ichikawa, “Facile Synthesis of
Polycyclic

AromaticHydrocarbons:

Brønsted

AcidCatalyzed

Dehydrative

Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3-Hexafluoropropan-2-ol,” Eur. J.
Org. Chem., 262–265 (2017).
18) N. Suzuki, T. Fujita, K. Y. Amsharov, J. Ichikawa, “Aluminium-Mediated Aromatic C–F
BondActivation:

Regioswitchable

ConstructionofBenzene-fused

TriphenyleneFrameworks,” Chem. Commun., 52, 12948–12951 (2016). Highlighted as Inside Front
Cover Picture: Chem. Commun., 52, 12918 (2016).
19) T. Fujita, Y. Watabe, S. Yamashita, H. Tanabe, T. Nojima, J. Ichikawa, “Silver-Catalyzed
VinylicC–F

Bond

Activation:

Synthesisof2-Fluoroindoles

fromβ,β-Difluoro-o-sulfonamidostyrenes,” Chem. Lett., 45, 964–966 (2016). Highlighted as
Editor’s Choice.
20) T. Fujita, K. Sugiyama, S. Sanada, T. Ichitsuka, J. Ichikawa, “Platform for Ring-FluorinatedBenzoheterole Derivatives: Palladium-Catalyzed Regioselective 1,1-Difluoroallylation andHeck Cyclization,” Org. Lett., 18, 248–251 (2016). Highlighted in Synfacts, 12, 264 (2016).
21) T. Fujita, T. Arita, T. Ichitsuka, J. Ichikawa, “Catalytic Defluorinative [3 + 2] Cycloadditionof Trifluoromethylalkenes with Alkynes via Reduction of Nickel(II) Fluoride Species,”
Dalton Trans., 44, 19460–19463 (2015).
22) N. Suzuki, T. Fujita, J. Ichikawa, “Method for the Synthesis of Dibenzo[g,p]Chrysenes:
Domino Friedel–Crafts-type Cyclization of Difluoroethenes Bearing Two Biaryl Groups,”
Org. Lett., 17, 4984–4987 (2015). Highlighted in Synfacts, 11, 1266 (2015).
23) T. Ichitsuka, T. Fujita, J. Ichikawa, “Nickel-Catalyzed Allylic C(sp3)–F Bond Activation ofTrifluoromethyl Groups via Fluorine Elimination: Synthesis of Difluoro-1,4-dienes,” ACS
Catal., 5, 5947–5950 (2015).
24) T. Fujita, Y. Watabe, T. Ichitsuka, J. Ichikawa, “Ni-Catalyzed Synthesis of Fluoroarenes
via [2+2+2] Cycloaddition Involving α-Fluorine Elimination,” Chem. Eur. J., 21, 13225–13228 (2015).
25) K. Fuchibe, T. Morikawa, K. Shigeno, T. Fujita, J. Ichikawa, “Pinpoint-FluorinatedPhenacenes: New Synthesis and Solubility Enhancement Strategies,” Org. Lett., 17, 1126–1129 (2015).
26) T. Ichitsuka, T. Takanohashi, T. Fujita, J. Ichikawa, “A Versatile Difluorovinylation
Method: Cross-Coupling Reactions of the 2,2-Difluorovinylzinc–TMEDA Complex withAlkenyl, Alkynyl, Allyl, and Benzyl Halides,” J. Fluorine Chem., 170, 29–37 (2015).
27) T. Ichitsuka, T. Fujita, T. Arita, J. Ichikawa, “Double C–F Bond Activation via β-Fluorine
Elimination: Nickel-Mediated [3+2] Cycloaddition of 2-Trifluoromethyl-1-alkenes withAlkynes,” Angew. Chem. Int. Ed., 53, 7564–7568 (2014). Highlighted as Front CoverPicture: Angew. Chem. Int. Ed., 53, 7371 (2014).
28) T. Fujita, M. Ikeda, M. Hattori, K. Sakoda, J. Ichikawa, “Nucleophilic 5-endo-trig
Cyclization of 3,3-Difluoroallylic Metal Enolates and Enamides: Facile Synthesis of
Ring-Fluorinated Dihydroheteroles,” Synthesis, 46, 1493–1505 (2014).
29) T. Fujita, S. Sanada, Y. Chiba, K. Sugiyama, J. Ichikawa, “Two-Step Synthesis ofDifluoromethyl-Substituted 2,3-Dihydrobenzoheteroles,” Org. Lett., 16, 1398–1401 (2014).
30) J. Ichikawa, H. Tanabe, S. Yoshida, T. Kawai, M. Shinjo, T. Fujita, “A New Organic
Two-Electron Oxidant: 9,10-Diaryl-9,10-dihydroanthracene-9,10-bis(ylium),” Chem. AsianJ., 8, 2588–2591 (2013).
31) T. Fujita, N. Suzuki, T. Ichitsuka, J. Ichikawa, “Facile Synthesis of Unsymmetrical
1,1-Diaryl-2,2-difluoroethenes via Stepwise Coupling of 1,1-Dibromo-2,2-difluoroethenes,”
J. Fluorine Chem., 155, 97–101 (2013).
32) T. Fujita, K. Sakoda, M. Ikeda, M. Hattori, J. Ichikawa, “Nucleophilic 5-endo-trig
Cyclizationof3,3-DifluoroallylicKetone

Enolates:Synthesisof5-Fluorinated

2-Alkylidene-2,3-dihydrofurans,” Synlett, 24, 57–60 (2013).
33) T. Fujita, Y. Matsuo, E. Nakamura, “Synthesis of Tetradeca- and Pentadeca(organo)[60]fullerenes Containing Unique Photo- and Electroluminescent π-Conjugated Systems,”
Chem. Mater., 24, 3972–3980 (2012).
34) P.-S. Lee, T. Fujita, N. Yoshikai, “Cobalt-Catalyzed, Room-Temperature Addition of
Aromatic Imines to Alkynes via Directed C–H Bond Activation,” J. Am. Chem. Soc., 133,17283–17295 (2011).
35) T. Fujita, T. Ichitsuka, K. Fuchibe, J. Ichikawa, “Facile Synthesis of β,β-Difluorostyrenes
via the Negishi Coupling of Thermally Stable 2,2-Difluorovinyl Zinc–TMEDA Complex,”
Chem. Lett., 40, 986–988 (2011).
36) K. Gao, P.-S. Lee, T. Fujita, N. Yoshikai, “Cobalt-Catalyzed Hydroarylation of Alkynes
through Chelation-Assisted C–H Bond Activation,” J. Am. Chem. Soc., 132, 12249–12251(2010).

37) T. Fujita, Y. Matsuo, E. Nakamura, “Reductive Benzylation of Dimetallo Hexaaryl[70]fullerenes on the Equatorial Region,” Chem. Asian J., 5, 835–840 (2010).
38) I. Paterson, G. J. Naylor, T. Fujita, E. Guzmán, A. E. Wright, “Total Synthesis of a Libraryof Designed Hybrids of the Microtubule-Stabilising Anticancer Agents Taxol,
Discodermolide and Dictyostatin,” Chem. Commun., 46, 261–263 (2010).
39) Y. Matsuo, K. Tahara, T. Fujita, E. Nakamura, “Di- and Trinuclear [70]FullereneComplexes: Syntheses and Metal–Metal Electronic Interactions,” Angew. Chem. Int. Ed., 48,6239–6241 (2009).
40) Y. Matsuo, T. Fujita, E. Nakamura, “Hoop-shaped Condensed Aromatic System: Synthesis
and Structure of Iron– and Ruthenium–Hepta(organo)[60]fullerene Complexes,” Chem.
Asian J., 2, 948–955 (2007).

<Reviews/Books>
1) 渕辺耕平, 藤田健志, 市川淳士,「有機半導体材料としてのピンポイントフッ素化
PAH」月刊『化学工業』「特集／フッ素化学による新技術開発」, 化学工業社, 2019年 8 月号, pp 48–55.
2) T. Fujita, K. Fuchibe, J. Ichikawa, “Transition Metal-Mediated and -Catalyzed C–F Bond
Activation via Fluorine Elimination,” Angew. Chem. Int. Ed., 58, 390–402 (2019).
3) 渕辺耕平, 藤田健志, 市川淳士,「ピンポイントフッ素化多環式芳香族炭化水素（F-PAH）: フルオロアルケンの求電子的活性化による合成と性質」, 有機合成化学協会誌, 76, 938–953 (2018).
4) 藤田健志, 渕辺耕平, 市川淳士, 「フッ素脱離を利用する炭素−フッ素結合活性化反応の現状」, 今野勉監修「有機フッ素化合物の最新動向」, シーエムシー出版, pp 74–93 (2018).
5) T. Fujita, J. Ichikawa, “Synthetic Methods for Ring-Fluorinated Pyrrole Derivatives,”
Heterocycles, 95, 694–714 (2017).
6) 藤田健志, 市川淳士，「フッ素化学入門 2015 — フッ素化合物の合成法」, 三共出版,
pp 112–115, 172–175, 178–181, 193–199 (2015).
7) T. Fujita, J. Ichikawa, “Syntheses, Properties, and Applications of Fluorinated Isoquinolines”

in “Fluorine in Heterocyclic Chemistry Volume 2,” V. Nenajdenko Ed., Springer, pp 181–210 (2014).

<Commentary>1) 藤田健志，「フッ素に“+”が乗った!?」 月刊『化学』「2013 年の化学: 注目の論文」,
化学同人, 2014 年 3 月号, pp 62–63.

<Patents>
1) 市川淳士，藤田健志，高橋一光，「１，１，１，３，３，３－ヘキサフルオロプロ
パ ン － ２ － オ ー ル と 脂 肪 族 炭 化 水 素 系 溶 媒 を 用 い た 二 相 系 反 応 媒 体 」， 特 開2018-145123 (2018)．
2) 中村栄一，松尾豊，藤田健志，「単分子トランジスタおよび単分子トランジスタに用いるフラーレン誘導体」，特開 2008-288421 (2008).