Meeting Scedule

International Meeting on RECQ Helicases
and Related Diseases 2018
Friday 16 - Sunday 18 February 2018, Kazusa Akademia Hall, Chiba, JAPANDay1 Feb 16th (Fri)
12:30-12:40

Opening Remarks
Koutaro Yokote (Chiba University, Chiba, Japan)

12:40-13:30

Plenary Lecture 1
Chair: Koutaro Yokote (Chiba University, Chiba, Japan)
The Werner Syndrome: Past, Present & Future
George M. Martin (University of Washington, Seattle, USA)
Session 1 Clinical Features and Genetics of Werner Syndrome
Chairs: Raymond J. Monnat (University of Washington, Seattle, USA)
Seijiro Mori (Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan)

13:30-14:00

Lessons from Werner syndrome :A biased view from a rheumatologist
Makoto Goto (Nerima Hikarigaoka Hospital, Tokyo, Japan)

14:00-14:30

Genomic clues to Werner syndrome disease pathogenesis and cancer risk
Raymond J. Monnat (University of Washington, Seattle, USA)

14:30-15:00

International Registry of Werner Syndrome: Search for progeroid syndrome mutations andmechanisms
Junko Oshima (University of Washington, Seattle, USA)
Session 2 Bloom Syndrome and Stem Cell Aging in Skin
Chairs: Nathan A. Ellis (University of Arizona, Tucson, USA)Seiichiro Motegi (Gunma University, Maebashi, Japan)

15:10-15:40

NSMCE2 is required for the generation of sister chromatid exchanges at collapsed replication forks
Nathan A. Ellis (University of Arizona, Tucson, USA)

15:40-16:10

Altered Nucleolar Trafficking of the Blm Helicase in the Mouse Reduces Size,
Increases Tumor Susceptibility and Genome Instability, and Facilitates Aging
Joanna L. Groden (The Ohio State University, Columbus, USA)

16:10-16:40

Stem cells orchestrate hair follicle aging program
Emi Nishimura (Tokyo Medical and Dental University, Tokyo, Japan)
Patients and Families Session
Chairs: Joanna L. Groden (The Ohio State University, Columbus, USA)
Yoshiro Maezawa (Chiba University, Chiba, Japan)

16:40-17:00

From Werner syndrome patient group17:00-17:15

From Cockayne syndrome patient group

17:15-17:35

From Rothmund-Thomson syndrome patient group

17:40-19:10: Poster Session
Welcome Reception at Hotel Okura−5−

Day2 Feb 17th (Sat)08:30-09:20

Plenary Lecture 2
Chair: Hironori Nakagami (Osaka University, Osaka, Japan)
Werner syndrome: mechanisms and intervention
Vilhelm A. Bohr (National Institute of Aging, Bethesda, USA)
Session 3 Travel Award Presentations and Mini Presentations of Poster Presenters
Chairs: Junko Oshima (University of Washington, Seattle, USA)
Minoru Takemoto (International University of Health and Welfare, Narita, Japan)

09:20-11:20

Travel Awardees and All the Poster
Presenters

11:30-12:20

Luncheon Seminar (Sponsored by
Novo nordisk Pharma Limited)

Room B
Patients and Families Meeting(in Japanese)
Chairs: Kazuki Kobayashi(Asahi General Hospital, Chiba,Japan)
Kinue Kuzuta(Chiba University, Chiba, Japan)

Chair: Shigeki Kuzuhara (Suzuka
University of Medical Science,Suzuka, Japan)
Werner Syndrome Research in Japan:
For the Patient and Aging Science
Koutaro Yokote (Chiba University,Chiba, Japan)

09:20-11:20

Session 4 Rothmund-Thomson
Syndrome, Mitochondrial Dysfunction
and Aging
Chairs: Lisa L. Wang (Texas Children’sHospital, Baylor College of Medicine,Houston, USA)
Hideo Kaneko (Nagara MedicalCenter, Gifu, Japan)
12:30-13:00

Update on Clinical Studies ofRothmund-Thomson Syndrome andRECQL4 Disorders
Lisa L. Wang (Texas Children’s Hospital,Baylor College of Medicine, Houston,USA)

13:00-13:30

Role of RECQL4 in genome
maintenance
Deborah L. Croteau (National Instituteon Aging, Bethesda, USA)

13:30-14:00

Mitol dependent ubiquitylation ofRECQL4 prevents its function as anaccessory factor for mitochondrial DNA
replication
Sagar Sengupta (National Institute ofImmunology, New Delhi, India)

14:00-14:30

Roles of mitochondrial ubiquitin ligase
MITOL in mitochondrial dynamics andaging-related diseases
Shigeru Yanagi (Tokyo University ofPharmacy and Life Sciences, Tokyo,Japan)

From Patient group of Werner,Cockayne, Rothmund-Thomson
syndromes,Researchers and Doctors
Problem Oriented Sessions for Patients(in Japanese)
Chair: Kazuki Kobayashi(Asahi General Hospital, Chiba,Japan)

13:00-13:20

Diabetes mellitus and metabolicsyndrome
Yoshiro Maezawa(Chiba University, Chiba, Japan)

13:20-13:40

Skin ulcer and its prevention
Seiichiro Motegi(Gunma University, Maebashi, Japan)

13:40-

Good shoes for your health
Meister Karsten Rieche(Nature’s Walk, Chiba, Japan)−6−

14:30-15:20

Plenary Lecture 3
Chair: Yasuhiro Furuichi (GeneCare Research Institute, Kamakura, Japan)
Genome-Wide promotome and enhancerome analysis based on CAGE technology andits application to the identification of cancer biomarkers
Yoshihide Hayashizaki (Riken, Wako, Japan)
Session 5 Aging related Diseases and Hutchinson Gilford Progeria Syndrome(Co-sponsored by Daiichi Sankyo Company, Limited)
Chairs: Vilhelm A. Bohr (National Institute of Aging, Bethesda, USA)
Kenji Ihara (Oita University, Oita, Japan)

15:40-16:10

Mitotic death of cancer cells by gene silencing of RECQ helicases:
a preferential sensitivity of ovarian cancer cells to RECQL1-siRNA
Yasuhiro Furuichi (GeneCare Research Institute, Kamakura, Japan)

16:10-16:40

Role of Akt in skeletal muscle in anti-aging
Kohjiro Ueki (Tokyo University and National Center for Global Health and Medicine, Tokyo, Japan)

16:40-17:10

Immunometabolic regulation of cardiac homeostasis and heart failure in aging
Ichiro Manabe (Chiba University, Chiba, Japan)

17:10-17:40

The clinical characteristics of Asian patients with classical-type Hutchinson-Gilford progeria
syndrome
Kenji Ihara (Oita University, Oita, Japan)

17:40-18:30

Special Lecture:
Programs and Progress towards Treatments and The Cure For Children with Progeria
Leslie B. Gordon (Brown University, Providence, USA)
Photo Session
Dinner at Takaraya−7−

Day3 Feb 18th (Sun)08:00-08:50

Morning Seminar (Sponsored by MSD K.K.)
Chair: Yoichi Nabeshima (Foundation for Biomedical Research and Innovation, Kobe, Japan)
Roles and mechanisms of cellular senescence in aging and cancer
Eiji Hara (Osaka University, Cancer Institute, Osaka and Tokyo, Japan)

09:00-09:50

Plenary Lecture 4
Chair: Katsuo Sugita (Chiba University, Chiba, Japan)
Genome maintenance protects from aging and cancer: the impact of nutrition
Jan H. J. Hoeijmakers (Erasumus University, Rotterdam, Netherland)
Session 6 Xeroderma Pigmentosa and Cockayne syndrome
Chairs: Chikako Nishigori (Kobe University, Kobe, Japan)
Jan H. J. Hoeijmakers (Erasumus University, Rotterdam, Netherland)

09:50-10:20

Coordinated DNA damage recognition by xeroderma pigmentosum gene productsKaoru Sugasawa (Kobe University, Kobe, Japan)

10:20-10:50

The present status of Xeroderma pigmentosum in Japan-evaluation of symptoms by severity
scale score
Chikako Nishigori (Kobe University, Kobe, Japan)

10:50-11:20

Very mild Japanese Cockayne syndrome (type-IV) cases with a N-terminal truncation mutationin the ERCC6 / CSB gene
Tomoo Ogi (Nagoya University, Nagoya, Japan)
Session 7 Can iPS cells be Future Therapeutics?
Chairs: Koji Eto(Center for iPS Cell Research and Application, Kyoto and Chiba University, Chiba, Japan)
Guanghui Liu (Institute of Biophysics, Chinese Academy of Science, Beijing, China)

11:30-12:00

Using stem cell and gene editing techniques to study and treat aging-associated disorders
Guanghui Liu (Institute of Biophysics, Chinese Academy of Science, Beijing, China)

12:00-12:30

In vitro modeling of bilateral progressive hearing loss with human iPSC technology:
Cellular pathology and drug discovery
Masato Fujioka (Keio University, Tokyo, Japan)

12:30-13:00

Patient-specific iPS cells for neural disease modeling and drug screening
Wado Akamatsu (Juntendo University, Tokyo, Japan)

13:00-13:10

Closing Remarks
Koutaro Yokote (Chiba University, Chiba, Japan)−8−