,661 

KURRI-EKR-
35,17,661 
35,17.5- 212ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤࠕ➨  ᅇᏛ⾡ㅮ₇఍ሗᩥ㞟ࠖ
3URFHHGLQJVRI WKHVW .855,6FLHQWLILF0HHWLQJ㛤ദ᪥㸸ᖹᡂ  ᖺ  ᭶ ࠊ ᪥-DQXDU\  ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤ
5HVHDUFK5HDFWRU,QVWLWXWH.\RWR8QLYHUVLW\➨  ᅇி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤᏛ⾡ㅮ₇఍ࣉࣟࢢ࣒ࣛ

㛤ദ᪥㸸ᖹᡂ  ᖺ  ᭶  ᪥ ᮌ 㹼 ᭶  ᪥ 㔠 ཱྀ 㢌 Ⓨ ⾲ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤ஦ົᲷ఍㆟ᐊ
࣏ࢫࢱ࣮Ⓨ ⾲ྠᅗ᭩Ჷ఍㆟ᐊ ᭶  ᪥ ᮌ  㹼
㛤఍ࡢᣵᣜ㸦㹼㸧 ᡤ㛗 ᕝ➃♸ྖ䝥䝻䝆䜵䜽䝖◊✲ᡂᯝㅮ₇3- 㹼  ᗙ㛗 ᳃ᮏᖾ⏕ᨺᑕ⥺↷ᑕࡸຍ㱋࡟ࡼࡿ⺮ⓑ㉁ᦆയࡢ໬Ꮫⓗゎ᫂yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyᨺᑕ⥺⏕࿨⛉Ꮫ◊✲㒊㛛㸦ᨺᑕ⥺ᶵ⬟⏕໬Ꮫ◊✲ศ㔝㸧⸨஭⣖Ꮚ௚䝖䝢䝢䝑䜽ㅮ₇
7 㹼  ᗙ㛗 ⏣୰ᾈᇶᐃㄝࢆ㉺࠼ࠊ᪂ࡓ࡞ࣉࣛࢫࢳࢵࢡࢩࣥࢳ࣮ࣞࢩࣙࣥ≀㉁࡟㛵ࡍࡿ◊✲࡜ࡑࡢᛂ⏝yyyyyyyyཎᏊຊᇶ♏ᕤᏛ◊✲㒊㛛㸦ᨺᑕ⥺Ᏻ඲⟶⌮ᕤᏛ◊✲ศ㔝㸧
୰ᮧ⚽ோ
㸦ఇ



᠁㸧 㹼᪂ேㅮ
ㅮ₇
1 㹼  ᗙ㛗 Ḉ஭Ⰻ᠇ᩘ༑㹼ᩘⓒ 0H9 ࢖࢜ࣥࣅ࣮࣒↷ᑕሙࡢ฼⏝⎔ቃ㛤Ⓨ 㸫་⒪࣭ࣂ࢖࢜࠿ࡽᏱᐂࡲ࡛㸫yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyᨺᑕ⥺⏕࿨⛉Ꮫ◊✲㒊㛛㸦ᨺᑕ⥺་Ꮫ≀⌮Ꮫ◊✲ศ㔝㸧
㧗⏣༟ᚿ



䝖䝢䝑䜽ㅮ
ㅮ₇
7 㹼  ᗙ㛗 ❑⏣༟ぢ᪥ᮏ࡜࣋ࢺࢼ࣒࡟࠾ࡅࡿ⎔ቃၥ㢟ࡢゎỴࢆࡵࡊࡍᢏ⾡㛤Ⓨ㸫ᨺᑕᛶࢭࢩ࣒࢘࡜◉⣲ࡢ㝖ཤyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyཎᏊຊᇶ♏ᕤᏛ◊✲㒊㛛㸦ᨺᑕ⬟⎔ቃືែᕤᏛ◊✲ศ㔝㸧
⸨ᕝ㝧Ꮚ

i



䝖䝢䝑䜽ㅮ
ㅮ₇
7 㹼  ᗙ㛗 ᑠ㔝බ஧ᒁᡤ⭘⒆ไᚚࠊ㐲㝸㌿⛣ᢚไࠊཬࡧ⒴ᖿ⣽⬊≉ᛶ࡜ࡢ㛵㐃ᛶࢆຍ࿡ࡍࡿఇṆᮇ⭘⒆⣽⬊ࡢ≉ᛶゎᯒyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
ᨺᑕ⥺⏕࿨⛉Ꮫ◊✲㒊㛛㸦⢏Ꮚ⥺⏕≀Ꮫ◊✲ศ㔝㸧ቑỌៅ୍㑻௚㸦ఇ᠁㸧 㹼

୍⯡ㅮ₇㻌㻌 䠄䝫䝇䝍䞊Ⓨ⾲䠅 㸦㹼㸧3 㖄ࣅࢫ࣐ࢫจᅛ㐣⛬ࡢࣃࣝࢫ୰ᛶᏊ࢖࣓࣮ࢪࣥࢢyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ఀ⸨኱௓ࠊ㰺⸨Ὀྖ㸦ி኱⅔㸧ࠊబ⸨༤㝯㸦໭኱㸧ࠊ⠛ཎṊᑦ㸦ཎᏊຊᶵᵓ㸧
3 㖄ࣅࢫ࣐ࢫẼᾮ஧┦ὶ࡟࠾ࡼࡰࡍቨ㠃⃿ࢀᛶࡢᙳ㡪㸫ࣉ࣮ࣝయ⣔࡟࠾ࡅࡿ࣎࢖ࢻ⋡ィ 㸫yyyyyy
‫✄ۑ‬ᐩⰋኴࠊ᭷ྜྷ⋞㸦ி኱㝔㸧ࠊఀ⸨኱௓ࠊ㰺⸨Ὀྖ㸦ி኱⅔㸧
3 㖄ࣅࢫ࣐ࢫẼᾮ஧┦ὶ࡟࠾ࡼࡰࡍቨ㠃⃿ࢀᛶࡢᙳ㡪㸫ᙉไᑐὶయ⣔࡟࠾ࡅࡿ࣎࢖ࢻ⋡ィ 㸫yyyy
‫ۑ‬᭷ྜྷ⋞ࠊ✄ᐩⰋኴ㸦ி኱㝔㸧ࠊఀ⸨኱௓ࠊ㰺⸨Ὀྖ㸦ி኱⅔㸧
ࠊ୕ᓥ჆୍㑻㸦INSS㸧
3 Two-Phase Flow Structure in a Simulated Debris Ded yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy ‫ۑ‬Nava Milka (Kyoto Univ.), Ito Daisuke, Saito Yasushi (KURRI)
3 γ ⥺↷ᑕ࡟ࡼࡿࣛࢵࢺỈᬗయ α࠾ࡼࡧ βࢡࣜࢫࢱࣜࣥࡢ㓟໬ࠊ⬺࢔࣑ࢻ໬࠾ࡼࡧ␗ᛶ໬➼ࡢ⩻ヂᚋಟ㣭ࡢ㎿㏿ LC-MS/MS ศᯒyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬㔠ோồࠊ㰺⸨๛㸦ி኱⅔㸧
ࠊ㔠ᮏᑦᚿ㸦ᗈ኱║㸧ࠊ⸨஭ᬛᙪ㸦ᖇி኱㸧ࠊ⸨஭⣖Ꮚ㸦ி኱⅔㸧
3 Mo ⥺※ X ⥺ᑠゅᩓ஘⿦⨨ࡢඹྠ฼⏝㛤ጞyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬኱ሙὒḟ㑻ࠊబ⸨ಙᾈࠊ஭ୖ೔ኴ㑻ࠊᮡᒣṇ᫂㸦ி኱⅔㸧
3 Cu ⥺※ X ⥺ᑠゅᩓ஘⿦⨨ࡢඹྠ฼⏝㛤ጞyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬బ⸨ಙᾈࠊ኱ሙὒḟ㑻ࠊ஭ୖ೔ኴ㑻ࠊᮡᒣṇ᫂㸦ி኱⅔㸧
3 ୰ᛶᏊ↷ᑕᶍᨃ⇞ᩱࢹࣈࣜ࠿ࡽࡢ᰾✀⁐ฟᣲືヨᩱㄪ〇yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᆏᮏᓧ୍ࠊబࠎᮌ㝯அࠊᑠᯘ኱ᚿ㸦ி኱㝔ᕤ㸧ࠊ⛅ᒣ኱㍜ࠊ᱒ᓥ㝧ࠊబ⸨ಟᙲ
㸦ᮾ໭኱ከඖ◊㸧3 J-PARC/MLF BL06 ୰ᛶᏊඹ㬆ࢫࣆ࢚ࣥࢥ࣮ศගჾ⩌ VIN ROSE ࡜୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨࡢ⌧≧ yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬᪥㔝ṇ⿱ࠊᑠ⏣㐩㑻ࠊྜྷỌᑦ⏕ࠊ㔠ᒣ㞞ဢࠊᕝ➃♸ྖ㸦ி኱⅔㸧ࠊ㐲⸨ோࠊᒣ⏣ᝅྐ.(. ࠊ⣽␊ᣅஓࠊṊ⏣᫴ࠊ㒌Ụࠊᒣᙧ㇏㸦⌮◊㸧ࠊ᳃⏣᫴ஓ㸦㟁ᶵ኱㸧ࠊྂᆏ㐨ᘯ㸦໭኱㸧ࠊ℩ᡞ⚽⣖㸦.(.㸧ii3 KUR-IBS ࢆ⏝࠸ࡓ◊✲ᒎ㛤yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬᪥㔝ṇ⿱ࠊᑠ⏣㐩㑻ࠊ㊊❧ᮃࠊ኱ሙὒḟ㑻ࠊྜྷỌᑦ⏕ࠊᮡᒣṇ᫂ࠊᕝ➃♸ྖ㸦ி኱⅔㸧
3 ໟ᥋໬ྜ≀ࢆ฼⏝ࡋࡓぶỈᛶ㧗ศᏊ࡜㔠ᒓሷ࡜ࡢࢥ࣏ࣥࢪࢵࢺࡢస〇[V]㹼␯Ỉᛶ⾲㠃ࡢᨵ㉁㹼yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᕝཱྀ᫛ኵ㸦ி኱⅔㸧
3 ᐆ▼ホ౯࡟ྥࡅࡓගᏛⓗ㛫᥋ᢞᙳἲyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᕝཱྀ᫛ኵ㸦ி኱⅔㸧
ࠊ஧ᐑὒᩥ㸦஧ᐑᐆ▼ ᰴ 㸧
3 B-3 ᑠᆺከ┠ⓗ୰ᛶᏊᅇᢡィᘓタࡢ㐍ᤖ≧ἣyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᑠ㔝ᑎ㝧ᖹࠊ᳃୍ᗈࠊྜྷ㔝Ὀྐ㸦ி኱⅔㸧ࠊబ⸨⠇ኵ㸦.(.㸧ࠊᖹ㈡ᬕᘯࠊᒾ℩ㅬ஧㸦Ⲉᇛ኱㸧ࠊሷ㔝㈗኱ࠊᯇ⏣ᾈᖹ㸦ி኱㝔ᕤ㸧
3 ⚟ᓥཎⓎ஦ᨾ࡟ࡼࡿ᪥ᮏ⏘ࣇࢺ࣑࣑ࢬᒓ㸦Genus Pheretima㸧࡬ࡢᨺᑕᛶࢭࢩ࣒࢘ࡢ
⛣⾜࡜యෆືែyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫⏣ۑ‬୰ⲡኴ㸦ி኱㎰㸧
ࠊ㊊㐩ኴ㑻㸦ᮾி㎰ᴗ኱Ꮫ㸧ࠊ⸨ཎ៞Ꮚࠊ㧗ᶫ▱அࠊ㧗ᶫ༓ኴ㑻㸦ி኱⅔㸧
3 Zr ࠾ࡼࡧ Pd ࡢ⏘ᴗ฼⏝ࡢ⌧≧࡜⎔ቃືែ㸸㛗ᑑ࿨᰾ศ⿣᰾✀ࡢ෌฼⏝࡟క࠺⿕ࡤࡃ⥺㔞ࡢホ౯ࡢほⅬ࠿ࡽyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᒾ⏣ె௦Ꮚࠊ⏣୰ⲡኴࠊ㧗ᓥ┤㈗㸦ி኱㎰㸧ࠊ㧗ᶫ▱அࠊ㧗ᶫ༓ኴ㑻㸦ி኱⅔㸧
3 γ ⥺↷ᑕ㑏ඖἲࢆ⏝࠸ࡓከඖ⣔㔠ᒓࢼࣀᚤ⢏Ꮚࡢྜᡂyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᡞ⏣᫴ኴ㑻ࠊ⏣୰ඖᙯࠊᮾᾏ᪫ᏹࠊ௰す✑㧗ࠊ㇂┿ᾏ㸦㜰ᗓ኱ᕤ㸧ࠊ⯆ὠ೺஧㸦㜰ᗓ኱⌧ࢩࢫ㸧ࠊỈ㉺ඞᙲ㸦ᮾ໭኱㔠◊㸧ࠊᒾ℩ᙲᏹ㸦㜰ᗓ኱ᕤ㸧ࠊ㜰ᮏ㞞᫛ࠊᚎ⹹
㸦ி኱⅔㸧ࠊᇼྐㄝ㸦㜰ᗓ኱ᕤ㸧
3 㟁Ꮚ⥺↷ᑕ FeAl 㔠ᒓ㛫໬ྜ≀୰ࡢ✵Ꮝ࡟ࡼࡿỈ⣲ᤕ⋓yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ୖۑ‬㔝㝧ᖹࠊᒾ℩ᙲᏹ㸦኱㜰ᗓ኱㸧ࠊᚎ⹹㸦ி኱⅔㸧ࠊబ⸨⣫୍㸦㮵ඣᓥ኱㸧ࠊ኱⃝୍ே㸦஑኱ᛂຊ◊㸧ࠊἙ〈ཌ⏨ࠊ๓ᕝ㞞ᶞࠊᩪ⸨ຬ୍㸦ཎᏊຊᶵᵓ㸧ࠊᇼྐㄝ㸦኱㜰ᗓ኱㸧
3 ᨺᑕ⬟ởᰁ᳨ᰝ⿦⨨ࡢ㛤Ⓨyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ዟᮧⰋࠊᒣ⏣㎮▮㸦ி኱⅔㸧
3 ⁐ᾮ࢚࢔ࣟࢰࣝ࡬ࡢ᰾ศ⿣⏕ᡂ≀ࡢ௜╔ᣲື࡟࠾ࡅࡿ⁐㉁ࡢᙳ㡪yyyyyyyyyyyyyyyyyyyyyyy‫ۑ‬す⃝భ௓㸦ி኱㝔ᕤ㸧㧗ᐑᖾ୍ࠊ㛵ᮏಇࠊἈ㞝୍ࠊ኱ᵳ໅㸦ி኱⅔㸧
3 ࣄࢺ⾑Ύ୰ࡢ D-࢔࣑ࣀ㓟ྵ᭷࣌ࣉࢳࢻࡢ᥈⣴ཬࡧྠᐃyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬Ha Seongmin㸦ி኱⌮㸧⸨஭⣖Ꮚ㸦ி኱⅔㸧
3 㓟໬࣐ࢢࢿࢩ࣒࢘࡜ྵ᭷ࢺࣜࢳ࣒࢘ỈࡢỈ㓟໬≀໬཯ᛂ࡟ࡼࡿࢺࣜࢳ࣒࢘ศ㞳ࡢྍ⬟ᛶyyyy
‫ۑ‬ᶫ∎⚽ኵ㸦≀ᮦᶵᵓ㸧ୖཎ❶ᐶࠊ⚟㇂ဴ㸦ி኱⅔㸧
ࠊ⸨஭࿴ᏊࠊᏳ⸨ᑑᾈ㸦≀ᮦᶵᵓ㸧
3 ࣟࢵࢻࣂࣥࢻࣝෆẼᾮ஧┦ὶ⏝⏺㠃✚⃰ᗘ㍺㏦ࣔࢹࣝyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ỿ⚽୰㸦ி኱⅔㸧㒭ಖ៞㸦ୖᾏ⌮ᕤ኱㸧
3 ⺮ⓑ㉁ࡢỈ࿴ᵓ㐀ゎ᫂࡟ྥࡅࡓ D/H ࢥࣥࢺࣛࢫࢺἲࡢ฼⏝yyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫➉Ⲕۑ‬ಇ⾜㸦ி኱⅔㸧
ࠊ⸨ཎᝅ 㔞◊ᶵᵓiii

3 ⣡㇋⳦⏤᮶ MK-7 ࡢᵓ㐀≉ᛶ࠾ࡼࡧ⣡㇋⳦ࡢ࣐࢞ࣥ⥺⪏ᛶࡢ◊✲yyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬ᰗ⃝Ὀ௵ࠊ㧘᰿ග⣪ࠊ㊊❧㐩⨾㸦༓⛉኱⸆㸧ࠊⲔ➉ಇ⾜ࠊ㰺⸨๛ࠊ஭ୖ೔ኴ㑻ࠊᮡᒣṇ᫂㸦ி኱⅔㸧ࠊᯇᑿ㱟ேࠊ⸨ཎᝅ㸦㔞◊ᶵᵓ㸧ࠊ኱ᮡᛅ๎ࠊ㡲ぢὒ⾜㸦಴ᩜⱁ⛉Ꮫ኱⏕࿨㸧
3 ࢼࣀ⤌⧊໬ࡋࡓ㕲㗰ᮦᩱ⾲㠃࡟ᙧᡂࡍࡿ₶⁥Ἔ⭷ほᐹ࡟ྥࡅ࡚yyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬㊊❧ᮃࠊ᪥㔝ṇ⿱ࠊ኱ሙὒḟ㑻㸦ி኱⅔㸧
ࠊᡞ㧗⩏୍㸦㇏ᶫᢏ⛉኱㸧
3 J-PARC MLF BL06 ࡟࠾ࡅࡿTOF-MIEZEᆺࢫࣆ࢚ࣥࢥ࣮ศගἲ࡟ࡘ࠸࡚ࡢ◊✲yyyyyyyyyy
‫ۑ‬ᑠ⏣㐩㑻ࠊ᪥㔝ṇ⿱ࠊᕝ➃♸ྖ㸦ி኱⅔㸧ࠊ㐲⸨ோࠊᒣ⏣ᝅྐࠊ℩ᡞ⚽⣖㸦.(.㸧3 α ቯኚ཯㊴᰾ PTh ࢆᤕ㞟ࡋࡓヨᩱ࠿ࡽࡢ┿✵⣸እග ᐃyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬Ᏻ⏣ຬ㍤ࠊ➟ᯇⰋᓫࠊ㔜Ἑඃ኱㸦㜰኱㝔⌮㸧ࠊ㧘ᐑᖾ୍ࠊ኱ᵳ໅㸦ி኱⅔㸧ࠊ୕㢌⫄᫂㸦ᮾ໭኱㔠◊࣭኱Ὑ㸧ࠊ⠛ཎཌ㸦㜰኱㝔⌮㸧
3 ⚟ᓥ࡛᥇ྲྀࡋࡓᨺᑕᛶࢭࢩ࣒࢘ࢆྵࡴᚤ⢏Ꮚࡢ⤌ᡂศᯒyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy‫ۑ‬すᒣ㞝኱㸦ி኱ᕤ㸧ࠊ㧗ᐑᖾ୍ࠊ㛵ᮏಇࠊἈ㞝୍ࠊ኱ᵳ໅㸦ி኱⅔㸧
3 NC ไᚚຍᕤ⿦⨨࡟ࡼࡿᅇ㌿ᴃ෇య୰ᛶᏊ࣑࣮ࣛࡢ〇స IIyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ྜྷۑ‬Ọᑦ⏕ࠊ᪥㔝ṇ⿱ࠊ㔠ᒣ㞞ဢ㸦ி኱⅔㸧ࠊ⣽␊ᣅஓࠊᒣᙧ㇏ࠊ㒌Ụ㸦⌮◊㸧ࠊ᳃⏣᫴ஓ㸦ᮾி㟁኱㸧
ࠊṊ⏣᫴ࠊྂᆏ㐨ᘯ㸦⌮◊㸧ࠊᕝ➃♸ྖ㸦ி኱⅔㸧
3 ࢧࣥࢦ⏤᮶ࣞࢡࢳࣥ㸲⢾」ྜయࡢ⤖ᬗᵓ㐀yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
‫ۑ‬႐⏣᫛Ꮚ㸦ி኱⅔㸧
ࠊ⚄ಖ඘㸦໭㔛኱ᾏὒ⏕࿨㸧ࠊ㓇஭㝯୍㸦໭኱㝔Ỉ⏘⛉Ꮫ㸧ࠊ᳃ᮏᖾ⏕㸦ி኱⅔㸧ࠊṊෆⰋኴ㸦ᮾᕤ኱㝔≀㉁⌮ᕤ㸧ࠊ⏣୰ᾈኈ㸦ᮾᕤ኱㝔≀㉁⌮ᕤ㸧ࠊ㧗ᶫᏕᚿ㸦ᶓ὾⸆኱㸧
ࠊ୕ᮌ㑥ኵ㸦ி኱㝔⌮㸧
3 Th Ỉ㓟໬≀ᅛ┦ࡢ⁐ゎᗘ✚࡟ཬࡰࡍ ᗘᙳ㡪ࡢゎ㔘yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy‫ۑ‬すᕝᑗ࿃ࠊᑠᯘ኱ᚿࠊబࠎᮌ㝯அ㸦ி኱㝔ᕤ㸧ࠊୖཎ❶ᐶ㸦ி኱⅔㸧
3 ࢫࢺࣟࣥࢳ࣒࢘ཬࡧ࢝ࣝࢩ࣒࢘ࡢ໬Ꮫ஺᥮ἲ࡟࠾ࡅࡿྠ఩యศู◊✲III yyyyyyyyyyyyyyy ‫◶ۑ‬㝯ኴࠊ⩏ᮏᏕ᫂㸦኱⏘኱㸧ࠊబஂ㛫ὒ୍㸦ᮾᕤ኱ཎᏊ⅔㸧
ࠊ⸨஭ಇ⾜㸦㜰኱ᕤ㸧ࠊ⚟㇂ဴࠊⰪཎ㞝ྖ㸦ி኱⅔㸧
3 KUR B1 Ꮝࢆ฼⏝ࡋࡓప㏿㝧㟁Ꮚࣅ࣮࣒ࣛ࢖ࣥ㍤ᗘቑᙉ㒊ࡢ㛤Ⓨyyyyyyyyyyyyyyyyyyyyyyyy
‫ⴱۑ‬㇂ెᗈ㸦ி኱㝔ᕤ㸧ࠊ኱ᓥỌᗣ㸦⏘⥲◊㸧ࠊᮌ㔝ᮧ῟ࠊ⡦ෆᩔ㸦ி኱⅔㸧ࠊబ⸨⣫୍㸦㮵ඣᓥ኱㸧
ࠊᚎ⹹㸦ி኱⅔㸧 ᭶  ᪥ 㔠  㹼
䝥䝻䝆䜵䜽䝖◊✲ᡂᯝㅮㅮ₇3- 㹼  ᗙ㛗 ᮌ᲍཭Ꮚ
BNCT ᐇ⏝໬࡟ྥࡅࡓᶫΏࡋ◊✲yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy⢏Ꮚ⥺⭘⒆Ꮫ◊✲ࢭࣥࢱ࣮㸦⢏Ꮚ⥺⭘⒆Ꮫ◊✲ศ㔝㸧㕥ᮌᐇ௚

iv

᪂ேㅮ
ㅮ₇
1 㹼  ᗙ㛗 ୰ᓥ೺
↷ᑕㄏ㉳⤖ᬗᛶᅇ᚟ࡢほ ࡜ࣔࢹࣜࣥࢢyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
ཎᏊຊᇶ♏ᕤᏛ◊✲㒊㛛㸦↷ᑕᮦᩱᕤᏛ◊✲ศ㔝㸧ᮌ㔝ᮧ῟
䝖䝢䝑䜽䝇ㅮ
ㅮ₇
7 㹼  ᗙ㛗 ᪥㔝ṇ⿱୰ᛶᏊᩓ஘ࢆ฼⏝ࡋࡓࣜࢳ࣒࢘࢖࢜ࣥ㟁ụ◊✲ࡢ᭱๓⥺yyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
⢏Ꮚ⥺ᇶ♏≀ᛶ◊✲㒊㛛㸦୰ᛶᏊᮦᩱ⛉Ꮫ◊✲ศ㔝㸧
᳃୍ᗈ

㸦ఇ

᠁㸧㹼

䝥䝻䝆䜵䜽䝖◊✲ᡂᯝㅮㅮ₇3- 㹼  ᗙ㛗 ᳃୍ᗈ
ከඖ⣲࣓ࢫࣂ࢘࢔࣮ศගἲࡢจ⦰⣔◊✲࡬ࡢ㧗ᗘᛂ⏝yyyyyyyyyyyyyyyyyyyyyyyyyyyyyyyy
⢏Ꮚ⥺ᇶ♏≀ᛶ◊✲㒊㛛㸦᰾ᨺᑕ≀⌮Ꮫ◊✲ศ㔝㸧℩ᡞㄔ௚㸦ఇ᠁㸧 㹼≉ูㅮ
ㅮ₇
6 㹼  ᗙ㛗 ᮡᒣṇ᫂⺮ⓑ㉁୰ࡢ D-࢔࣑ࣀ㓟ࢆᣦᶆ࡜ࡋࡓ⪁໬ࡢᇶ♏◊✲
㸦L-࢔࣑ࣀ㓟࣮࣡ࣝࢻ࡟࠾ࡅࡿࣃࣛ࢟ࣛࣜࢸ࢕ࡢᴫᛕࡢ㔜せᛶ㸧yyyyyyyyyyyyyyyyyyyyyyy
ᨺᑕ⥺⏕࿨⛉Ꮫ◊✲㒊㛛㸦ᨺᑕ⥺ᶵ⬟⏕໬Ꮫ◊✲ศ㔝㸧⸨஭⣖Ꮚ㛢఍ࡢᣵᣜ㸦㹼㸧 ᡤ㛗 ᕝ➃♸ྖv㻔㻼㻶㻝㻕 ᨺᑕ⥺↷ᑕࡸຍ㱋࡟ࡼࡿ⺮ⓑ㉁ᦆയࡢ໬Ꮫⓗゎ᫂㸦ி኱ཎᏊ⅔ࠊ㕥㮵་⒪኱  ࠊ୰㒊኱  ࠊጲ㊰⋊༠኱  ࠊᖇி኱  ᗈᓥ኱Ꮫ⑓㝔║⛉  㸧‫⸨ۑ‬஭⣖Ꮚࠊᮌ㔝ෆᛅ⛱ࠊ㰺⸨๛ࠊ㧗⏣໶ࠊ㔠 ோồࠊᐃ㔠㇏ ࠊ኱⚄ಙᏕ ࠊᏳᒱ೺୕ ࠊ⸨஭ᬛᙪ ࠊ㔠ᮏᑦᚿ 㸯㸬ࡣࡌࡵ࡟㸸ⓑෆ㞀ࠊ࢔ࣝࢶࣁ࢖࣐࣮⑓ࠊࣃ࣮࢟
ࣥࢯࣥ⑓ࠊື⬦◳໬ࠊຍ㱋ᛶ㞴⫈ࠊ⓶⭵◳໬➼ࡢຍ㱋ᛶ⑌ᝈࡣ⺮ⓑ㉁ࡢᵓ㐀␗ᖖࡢ⑌⑓࡜ࡋ࡚▱ࡽࢀ࡚࠸ࡿࠋࡑࡢཎᅉࡣࡇࢀࡽࡢ⤌⧊࡟ྵࡲࢀࡿ⺮ⓑ㉁ࡢ
␗ᖖจ㞟ࡀ୍ᅉ࡛࠶ࡾࠊᨺᑕ⥺ࠊ⣸እ⥺↷ᑕࠊ㓟໬ࢫࢺࣞࢫ࡟ࡼࡗ࡚㐍⾜ࡍࡿࠋࡋ࠿ࡋࠊ␗ᖖจ㞟ࡢࡁࡗ࠿ࡅࡣ໬Ꮫⓗ࡟ゎ᫂ࡉࢀ࡚࠾ࡽࡎࠊᝈ⪅ࡢᛴቑࡣ㧗㱋໬♫఍࡛῝้໬ࡋ࡚࠸ࡿࠋᮏ◊✲࡛ࡣᵝࠎ࡞ࢫࢺࣞࢫࢆཷࡅࡓ⺮ⓑ㉁୰ࡢ࢔࣑ࣀ㓟ṧᇶࡢ⩻ヂᚋಟ㣭㸦ࣛࢭ࣑໬ࠊ⬺࢔࣑ࢻ໬ࠊ㓟໬࡞࡝㸧ࡀ⺮ⓑ㉁ࡢ
ᵓ㐀ኚ໬ࠊᶵ⬟ኚ໬ࢆច㉳ࡍࡿࡶࡢ࡜⪃࠼ࠊࡑࡢ㐣⛬ࢆ໬Ꮫⓗ࡟ゎ᫂ࡋࠊ㜵ᚚἲࢆ᥈⣴ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ྛࢸ࣮࣐࡟ศࡅ࡚◊✲ࢆ㐍ࡵࡓࠋ㸧Ț ⥺↷ᑕ࡟ࡼࡿࣛࢵࢺỈᬗయࢡࣜࢫࢱࣜࣥࡢ㒊఩≉␗ⓗ㓟໬࡜⬺࢔࣑ࢻ໬㸦‫⸨ۑ‬஭⣖Ꮚࠊ㔠ோồࠊ㧗⏣໶ࠊ㔠ᮏᑦᚿ㸧࠙┠ⓗࠚ║ࡢỈᬗయࡣእ⏺࠿ࡽࡢගࢆ⥙⭷ୖ࡟⤖ീࡉࡏࡿ࡜࠸࠺ᶵ⬟ࢆ᭷ࡍࡿࠋỈᬗయࡢ㏱᫂ᛶࡣࡑࡢ
୺ᡂศ࡛࠶ࡿ αࠊβࠊγࢡࣜࢫࢱࣜࣥ(Cry)㛫ࡢ┦஫స⏝࡟ࡼࡗ࡚ಖᣢࡉࢀ࡚࠸ࡿࡀࠊ㓟໬ⓗࢫࢺࣞࢫࡸ
ຍ㱋࡟క࠸ࠊࡑࡢᵓᡂ࢔࣑ࣀ㓟ṧᇶ࡟㓟໬ࠊ⬺࢔࣑ࢻ໬ࠊ␗ᛶ໬࡞࡝ࡀ⏕ࡌࡿ࡜ࠊࡇࢀࡽ Cry 㛫ࡢ┦஫స⏝ࡀపୗࡋจ㞟࡜୙⁐໬ࡀ⏕ࡌࠊⓑෆ㞀ࡀⓎ⑕ࡍࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋⓑෆ㞀Ⓨ⑕ࡢእᅉ࡜ࡋ࡚㓟໬ⓗࢫࢺࣞࢫࡀᣦ᦬ࡉࢀ࡚࠸ࡿࡓࡵࠊᮏ◊✲࡛ࡣ  㐌㱋ࡢࣛࢵࢺỈᬗయ࡟ప⥺㔞ࡢ γ ⥺ࢆ↷ᑕࡋࠊ㓟໬ࡸ⬺࢔࣑ࢻ໬ࡀࣛࢵࢺࡢ Cry ࡟⏕㉳ࡍࡿ࠿ࠊࡲࡓࠊࡑ
ࡢ㒊఩ࡣࣄࢺࡢ⪁ேᛶⓑෆ㞀࡜ྠ୍㒊఩࡟⏕ࡌࡿ࠿࡝࠺࠿ࢆ᳨ウࡋࡓࠋγ ⥺↷ᑕ࡟ࡼࡿ⺮ⓑ㉁୰ࡢ࢔࣑ࣀ
㓟ṧᇶࡢ㓟໬࡟㛵ࡍࡿ◊✲ࡣ࠶ࡿࡀࠊ⬺࢔࣑ࢻ໬ࡀ
⏕ࡌࡿ࠿࡝࠺࠿ࡢ▱ぢࡣ࡞࠸ࠋ⬺࢔࣑ࢻ໬ࡣ⺮ⓑ㉁࡟㈇ࡢ㟁Ⲵࢆࡶࡓࡽࡍ㔜せ࡞ಟ㣭࡛࠶ࡾࠊࣄࢺࡢⓑෆ㞀࡛ࡣ㓟໬ࡼࡾࡶከࡃ⏕ࡌ࡚࠸ࡿಟ㣭ࡢࡓࡵࠊᮏ
◊✲࡛ࡢศᯒᑐ㇟࡜ࡋࡓࠋ
[᪉ἲ] 5-50 Gy ࡢ γ ⥺ࢆ 4 㐌㱋ࡢࣛࢵࢺỈᬗయ࡟↷ᑕࡋࠊ↷ᑕᚋࡢỈᬗయࢆ࣍ࣔࢪ࢙ࢼ࢖ࢬࡋࠊ㐲ᚰศ㞳࡟ࡼࡾྍ⁐ᛶ (WS)⏬ศ࡜୙⁐ᛶ(WI)⏬ศ࡟ศ㞳ࡋࡓࠋWS ࠾ࡼࡧ WI ⏬ศ࡟ྵࡲࢀࡿ඲ Cry ࢆࡑࢀࡒࢀࢺࣜࣉࢩࣥฎ⌮ࡋࠊ࣌ࣉࢳࢻ࡟᩿∦໬ࡋࡓࠋWI⏬ศࡣࢺࣜࣉࢩࣥฎ⌮࡟ඛ❧ࡕࠊ8 M ᒀ⣲࡛⁐ゎࡋࠊᒀ⣲⃰ᗘࢆ㸯M ࡟ῶࡌࡓᚋࠊࢺࣜࣉࢩࣥฎ⌮ࡋࡓࠋᚓࡽࢀࡓ࣌ࣉࢳࢻࢆ one-shot ࡛ LC/MS/MS ࡟ࡼࡾ୍ᩧศᯒࡋࡓࠋ࣌ࣉࢳࢻࡢྠᐃ࠾ࡼࡧ Cry ୰ࡢ࢔࣑ࣀ
㓟ṧᇶࡢ⩻ヂᚋಟ㣭࡟㛵ࡋ࡚ࡣ Proteome Discoverer࡟ࡼࡾゎᯒࢆ⾜ࡗࡓࠋྛ࢔࣑ࣀ㓟ṧᇶࡢ㓟໬ࡣ+16
ࡲࡓࡣ+32ࠊ⬺࢔࣑ࢻࡣ+1 ࡢ mass shift ࡛ศᯒࡋࡓࠋ
>⤖ᯝ࡜⪃ᐹ@ ᮍ↷ᑕ࡛ࡣࠊࡍ࡭࡚ࡢ Cry ࡟࠾࠸࡚㓟໬ࡶ⬺࢔࣑ࢻ໬ࡶ⏕ࡌ࡚࠸࡞࠿ࡗࡓࠋγ-Cry ࡢ㓟໬ࡣ㻙 㻝㻌㻙

5Gy ௨ୖࡢ↷ᑕ࡛⏕ࡌࠊγE, γF -Cry ࡢ Trp, Met, Cysṧᇶࡀ㓟໬ࡉࢀࡓࠋα-, β-Cry ࡛ࡣ 5 Gy ࡢ↷ᑕ࡛ࡣ㓟
໬ࡏࡎࠊ50 Gy ௨ୖࡢ↷ᑕ࡟ࡼࡗ࡚ึࡵ࡚ Met,Trp,Hisṧᇶ࡟㓟໬ࡀ⏕ࡌࡓࠋࡇࡢ⤖ᯝ࠿ࡽ γ-Cry ࡣ α-ࠊβ-Cry࡜ẚ㍑ࡋ࡚㓟໬ࡉࢀࡸࡍ࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋྛ Cryࡢ㓟໬㒊఩ࢆ Table 1 ࡟♧ࡋࡓࠋࡇࢀࡽࡣࣄࢺࡢຍ㱋ᛶⓑෆ㞀ࡢ Cry ࡛⏕ࡌ࡚࠸ࡿ㓟໬㒊఩࡜ඹ㏻ࡍࡿ㒊఩ࡀከ࠿ࡗࡓ [1]ࠋ
⾲ 1. 5-50 Gy ࡢ γ ⥺↷ᑕᚋࡢ WSࠊWI ⏬ศ࡟ྵࡲࢀ
ࡿ α-, β-, γ-crystallin ࡢ㓟໬㒊఩ኴᏐࡣⓑෆ㞀ᝈ⪅ࡢ㓟໬㒊఩࡜ඹ㏻ࡋ࡚࠸ࡿ㒊఩ḟ࡟ࠊα-, β-, γ-Cry ୰ࡢ⬺࢔࣑ࢻ໬࡟ࡘ࠸࡚ゎᯒࡋࡓ࡜ࡇࢁࠊ5 Gy ௨ୖࡢ γ ⥺↷ᑕ࡟ࡼࡗ࡚ࡍ࡭࡚ࡢ Cry࡟࠾࠸࡚ከᩘࡢ Asn ࠾ࡼࡧ Gln ṧᇶ࡛⬺࢔࣑ࢻ໬ࡀ
⏕ࡌ࡚࠸ࡓࠋࡇࢀࡽࡢ⬺࢔࣑ࢻ໬㒊఩ࡶࣄࢺຍ㱋ᛶⓑෆ㞀 Cry ࡟࠾࠸᳨࡚ฟࡉࢀ࡚࠸ࡿ㒊఩࡜ඹ㏻ࡋ࡚
࠸ࡓ[2]ࠋ⬺࢔࣑ࢻ໬࡟ࡼࡗ࡚ࠊAsn ṧᇶࡣ Asp ṧᇶ࡬ࠊGln ṧᇶࡣ Glu ṧᇶ࡬࡜ኚ໬ࡋࠊ⺮ⓑ㉁ഃ㙐࡟㈇ࡢ㟁Ⲵࡀࡶࡓࡽࡉࢀࡿࡓࡵࠊγ ⥺↷ᑕ࡟ࡼࡗ࡚ㄏᑟ
ࡉࢀࡓ⬺࢔࣑ࢻ໬ࡣ α-, β-, γ-Cry ࡢᵓ㐀࠾ࡼࡧ⺮ⓑ㉁㛫ࡢ┦஫స⏝࡟ኚ໬ࢆࡶࡓࡽࡍ࡜⪃࠼ࡽࢀࡿࠋࡇ
ࢀࢆ཯ᫎࡍࡿࡼ࠺࡟㓟໬ࡸ⬺࢔࣑ࢻ໬ࡣ WI ⏬ศ࡟ከࡃぢࡽࢀࡓࠋ⬺࢔࣑ࢻ໬ࡀ㓟໬ⓗࢫࢺࣞࢫ࡟ࡼࡗ
࡚ច㉳ࡍࡿࡇ࡜ࡀ໬Ꮫⓗ࡟᫂ࡽ࠿࡟࡞ࡾࠊ㜵ᚚ⟇ࢆㅮࡌࡿ࠺࠼࡛᭷⏝࡞ᣦ㔪࡜࡞ࡿ࡜⪃࠼ࡽࢀࡓࠋ
㸧'࢔ࢫࣃࣛࢠࣥ㓟ྵ᭷⺮ⓑ㉁࡟≉␗ⓗ࡞ศゎ㓝⣲ࡢ㐍໬⏕≀Ꮫⓗ◊✲㸦‫ۑ‬ᮌ㔝ෆᛅ⛱ࠊ⸨஭⣖Ꮚ㸧࠙┠ⓗࠚᡃࠎࡀ့ங㢮ࡼࡾⓎぢࡋࡓ D-࢔ࢫࣃࣛࢠࣥ
㓟࢚ࣥࢻ࣌ࣉࢳࢲ࣮ࢮ㸦 D-Aspartyl Endopeptidase:
DAEP㸧ࡣࠊຍ㱋࡟కࡗ࡚⏕ࡌࡿ D-Asp ྵ᭷⺮ⓑ㉁ࢆ
≉␗ⓗ࡟ศゎࡍࡿ㓝⣲㸸ࣉࣟࢸ࢔࣮ࢮࡢ୍✀࡛࠶ࡾࠊࡑࡢ⏕⌮ⓗព⩏ࡣࠊ⥺⥔໬ࡋ᫆ࡃẘᛶࡢ㧗࠸ D-Asp

ྵ᭷⺮ⓑ㉁ࢆ᤼㝖ࡍࡿࡇ࡜࡟ࡼࡗ࡚⣽⬊ࡢ೺඲ᛶࢆ
ᢸಖࡍࡿࡓࡵࡢရ㉁⟶⌮࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓ[3]ࠋ᪤
▱ࡢࣉࣟࢸ࢔࣮ࢮࡣࡍ࡭࡚ࠊ L-࢔࣑ࣀ㓟ࡔࡅ࠿ࡽ࡞
ࡿᇶ㉁ࢆศゎࡍࡿࠊゝ࠸᥮࠼ࡿ࡜ࠊ D-࢔࣑ࣀ㓟ࢆྵ
ࡴᇶ㉁ࢆศゎ࡛ࡁ࡞࠸ࡇ࡜࠿ࡽࠊDAEP ࡢ≉␗ᛶࡣ㠀ᖖ࡟㝿❧ࡗ࡚࠸ࡿࠋࡋࡓࡀࡗ࡚ࠊDAEP ࡢ⊂≉࡞ศᏊ㐍໬ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟ࠊࡑࡢ࣮ࣝࢶࢆ᥈ࡋ࡚ྂ ⣽⳦࠿ࡽ ့ங㢮࡟ ࠸ࡓࡿᵝ ࠎ࡞⏕≀ ✀࠿ ࡽ
DAEP άᛶࢆ᥈⣴ࡋࡓ࡜ࡇࢁࠊ⣽⳦㢮ࡸ㓝ẕࠊ⥺⹸࡛ࡣ DAEP άᛶࢆ᳨ฟࡍࡿࡇ࡜ࡣ࡛ࡁ࡞࠿ࡗࡓࡀࠊ
⬨᳝ື≀㸦့ங㢮ࠊ㫽㢮ࠊ୧⏕㢮ࠊ㨶㢮㸧࡜࢘ࢽ㢮࡟ࡑ ࡢάᛶ ࡀ ᳨ฟࡉࢀ ࡓࠋ࢔ࣇ ࣜ࢝ࢶ࣓ ࢚࢞ ࣝ
㸦Xenopus laevis㸧ࡸࣂࣇࣥ࢘ࢽ㸦Hemicentrotus pulcherrimus㸧࡛ࡣࠊDAEP άᛶࡢ⤌⧊ศᕸࡀ့ங㢮ࡸ㫽㢮࡜኱ࡁࡃ␗࡞ࡾࠊ⏕Ṫᕢࡸ༸⣽⬊࡛ࡢάᛶࡀ㧗࠸ࡇ࡜ࡀ≉ᚩⓗ࡛࠶ࡗࡓࠋࡑࡇ࡛ࠊ⬨᳝ື≀ࡢ┤⣔ࡢඛ♽࡛࠶ࡿ⬨⣴ື≀㸦࣍ࣖ㢮㸧࡜ࠊ᳜≀ࡸ᪻⹸࡞࡝ື≀௨እࡢ⏕≀࡟ࡘ࠸࡚ࡶ DAEP άᛶࢆㄪ࡭ࡿࡇ
࡜࡟ࡋࡓࠋ
࠙᪉ἲࠚDAEP άᛶ ᐃἲ㸸့ங㢮 DAEP ࡢ᥈⣴࡜ྠᐃࡢࡓࡵ࡟㛤Ⓨࡋࡓྜᡂᇶ㉁㸸Suc-[ D--Asp]-MCA
acid
D-(4-methyl-coumaryl(Succinyl-D-Aspartic
7-amide))ࢆࠊ㐺ᙜ࡟ᕼ㔘ࡋࡓ⤌⧊ᢳฟᾮ࡜ΰ࿴ࡋࡓࠋ
Suc-[D-Asp]-MCA ࡀ DAEP ࡟ࡼࡗ࡚ศゎࡉࢀࡿ࡜࢔
࣑ࣀ࣓ࢳࣝࢡ࣐ࣜࣥࡀ㐟㞳ࡉࢀࡿࡢ࡛ࠊࡇࢀࢆບ㉳Ἴ㛗 390 nmࠊ⺯ගἼ㛗 460 nm ࡛⤒᫬ⓗ࡟ィ ࡋࠊࡑࡢ⺯ගᙉᗘࢆ DAEP άᛶ࡜ࡋ࡚ぢ✚ࡶࡗࡓ[3]ࠋ
࠙⤖ᯝࠚ⬨⣴ື≀࡜ࡋ࡚࢝ࢱࣘ࢘ࣞ࢖࣎ࣖ㸦Ciona
intestinalis㸧ࢆゎ๗ᚋࠊᚰ⮚ࠊ༸ᕢࠊ⢭ᕢࠊ⫶ࠊ⭠ࠊ⢭༸⟶࡟ศࡅ࡚⤌⧊ᢳฟᾮࢆㄪ〇ࡋࠊࡑࢀࡒࢀ࡟࠾
ࡅࡿ DAEP άᛶࢆ ᐃࡋࡓ࡜ࡇࢁࠊ༸ᕢ࡜⢭ᕢ࡟ࡢࡳ DAEP άᛶࡀ᳨ฟࡉࢀࡓࠋࡇࡢࡼ࠺࡞ DAEP άᛶࡢ⤌⧊ศᕸࡣࠊ୧⏕㢮ࠊ㨶㢮ࠊ࢘ࢽ㢮࡜ྠᵝ࡛࠶ࡗࡓࠋࡑࡇ࡛ࠊ⬨᳝࣭⬨⣴ື≀௨እࡢከ⣽⬊⏕≀࡛࠶ࡿ᳜≀࡜᪻⹸࡟ࡘ࠸࡚ࡶࠊࡑࢀࡒࢀࡢ⏕Ṫ⤌⧊࡟࠾ࡅࡿ DAEP άᛶࢆ᳨ウࡋࡓࠋ᳜≀࠿ࡽࡣࣈࣟࢵࢥࣜ
࣮㸦BroccoliࠊBrassica oleracea var. italica㸧ࡢⰼⷣ㸦୍⯡ⓗ࡞ྍ㣗㒊ࠋ⬨᳝࣭⬨⣴ື≀ࡢ⏕Ṫᕢ࡟┦ᙜ㸧ࢆࠊ᪻⹸࠿ࡽࡣ࢝࢖ࢥ㸦Bombyx mori㸧ࡢ༸ᕢࢆ᥇ྲྀࡋࠊ
ୖグ᪉ἲ࡟๎ࡗ࡚ DAEP άᛶࢆ ᐃࡋࡓࠋࡑࡢ⤖ᯝࠊ࡝ࡕࡽ࠿ࡽࡶ DAEP άᛶࡣ᳨ฟ࡛ࡁ࡞࠿ࡗࡓࠋ
࠙⪃ᐹࠚ⬨᳝ື≀ࡢ┤⣔ࡢඛ♽࡛࠶ࡿ࢝ࢱࣘ࢘ࣞ࢖
࣎ࣖࡢ⏕Ṫᕢ࡟࠾࠸࡚ DAEP άᛶࡀ᳨ฟࡉࢀࡓࠋ୧
⏕㢮ࡸ㨶㢮ࠊ࢘ࢽ㢮࡛ࡶ DAEP άᛶࡣ⏕Ṫᕢ࡟ࡢࡳ≉␗ⓗ࡛࠶ࡗࡓࡇ࡜࠿ࡽࠊDAEP ࡢཎጞⓗ࡞⏕⌮ᶵ⬟ࡣࠊ᭷ᛶ⏕ṪࡸึᮇⓎ⏕࡟࠶ࡿࡢ࡛ࡣ࡞࠸࠿࡜⪃࠼ࡽࢀࠊࡑࡢᇶ㉁࡜࡞ࡿᮍ▱ࡢ D-Asp ྵ᭷⺮ⓑ㉁ࡢ
Ꮡᅾࡶ♧၀ࡉࢀࡓࠋ୍᪉ࠊ㫽㢮ࡸ့ங㢮࡛ࡣࠊ⏕Ṫᕢ௨እ࡟⫢⮚࡞࡝࡛ࡶ㧗࠸ DAEP άᛶࢆぢฟࡍࡇ࡜ࡀ࡛ࡁࡿࡓࡵࠊࡑࡢᚋࡢ⣔⤫㐍໬࡟ࡼࡗ࡚ࡇࢀࡽࡢ
㧗➼⬨᳝ື≀࡟ࡑࡢάᛶࡀᘬࡁ⥅ࡀࢀࠊDAEP ࡣရ㉁⟶⌮ᶵᵓ࡜ࡋ࡚ࡢᶵ⬟ࡀⓎ㐩ࡋࡓࡶࡢ࡜⪃࠼ࡽࢀࡓࠋࡲࡓࠊ᳜≀ࡸ᪻⹸࡛ࡣ᳨ฟ࡛ࡁ࡞࠿ࡗࡓࡇ࡜࠿
ࡽࠊ௒ᚋ DAEP ࡢศᏊ⣔⤫Ꮫⓗ࡞᳨ウࢆࡍࡿࡇ࡜࡟
ࡼࡗ࡚ࠊࡇࢀࡽࡢྛ⏕≀⣔⤫ࡢ㐍໬ୖࡢศᒱࢆ⢭⣽㻙 䢴㻌㻙࡟᥎ᐃ࡛ࡁࡿࡼ࠺࡟࡞ࡿ࡜ࡶ⪃࠼ࡽࢀࡓࠋ
㸧ᨺᑕ⥺↷ᑕ࡟ࡼࡿ⏕యศᏊᦆയ࡜ᨺᑕ⥺࡟ᑐࡍࡿ⏕య㜵ᚚᶵᵓ 㸦‫ۑ‬㰺⸨Ẏࠊ⸨஭⣖Ꮚ㸧࠙┠ⓗࠚ㟁㞳ᨺᑕ⥺࡟ࡼࡿ⏕≀ᙳ㡪ࡣ୺࡟ᨺᑕ⥺࡟ࡼࡗ࡚⏕ᡂࡍࡿ✀ࠎࡢࣛࢪ࢝ࣝࠊάᛶ㓟⣲࡟ࡼࡾច㉳ࡉࢀࡿࠋࡇࡢࡼ࠺࡞ᨺᑕ⥺࡟ᑐࡋ⏕యࡣከࡃࡢ㜵ㆤᶵᵓࢆഛ࠼࡚࠸ࡿࠋ࡜ࡇࢁ࡛ࠊ⮬↛⏺࡟ࡣᴟࡵ࡚
㧗࠸ᨺᑕ⥺᢬ᢠᛶࢆ᭷ࡍࡿᨺᑕ⥺⪏ᛶ⣽⳦࡜࿧ࡤࢀ
ࡿ⣽⳦⩌ࡀᏑᅾࡋ࡚࠸ࡿࠋࡑࡋ࡚ࠊࡑࡢඹ㏻ࡢ≉ᚩ࡜ࡋ࡚⣽⬊ෆ࡟࢝ࣟࢸࣀ࢖ࢻ⣔㉥ⰍⰍ⣲ࢆྵ᭷ࡋ࡚
࠸ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋࡲࡓࠊࡑࢀࡽᨺᑕ⥺⪏ᛶ⣽⳦ࡢ࢝ࣟࢸࣀ࢖ࢻ㠀⏘⏕ᰴࡣᨺᑕ⥺࡟ᑐࡋ࡚ឤཷ
ᛶ࡜࡞ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡇࢀࡽࡢࡇ࡜ࡼࡾࠊ
ᨺᑕ⥺⪏ᛶ⣽⳦ࡢᨺᑕ⥺⪏ᛶᶵᵓ࡟⣽⬊ྵ᭷࢝ࣟࢸ
ࣀ࢖ࢻࡀ㛵୚ࡋ࡚࠸ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋࡉࡽ࡟ࠊ
࢝ࣟࢸࣀ࢖ࢻࡣࣛࢪ࢝ࣝࢫ࢝࣋ࣥࢪࣥࢢάᛶࠊάᛶ㓟⣲㝖ཤάᛶࢆ᭷ࡍࡿࡇ࡜ࠊࡑࡋ࡚ᨺᑕ⥺⪏ᛶ⣽⳦⣽⬊୰࡟࠾࠸࡚࢝ࣟࢸࣀ࢖ࢻࡣ⣽⬊⭷➼⣽⬊⾲ᒙ⬡㉁㒊఩࡟ᒁᅾࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋࡇࢀ
ࡽࡢࡇ࡜ࡼࡾࠊᨺᑕ⥺⪏ᛶ⣽⳦࡟࠾࠸࡚ࡣࠊࡑࡢྵ
᭷࢝ࣟࢸࣀ࢖ࢻࡀᨺᑕ⥺࡟ࡼࡿ⣽⬊⭷➼ࡢ⬡㉁ࡢᦆ
യࢆᢚไࡋࠊࡦ࠸࡚ࡣ⺮ⓑ㉁➼ࡢ௚ࡢ⏕యศᏊࡢᦆ
യࢆࡶᢚไࡍࡿࡇ࡜࡟ࡼࡾ⏕యࢆ㜵ㆤࡋ࡚࠸ࡿ࡜࠸
࠺ᶵᵓࡀ⪃࠼ࡽࢀࡿࠋᮏ◊✲࡛ࡣࡇࡢࡼ࠺࡞⏕య㜵ㆤᶵᵓࢆゎ᫂ࡍࡿࡓࡵ࡟ࠊ௦⾲ⓗ࡞⏕య⬡㉁࡛࠶ࡿ
ࣜࣀࣞࣥ㓟࡬ࡢȚ⥺↷ᑕ࡟ࡼࡿᦆയ࡟ᑐࡍࡿ඾ᆺⓗ࢝ࣟࢸࣀ࢖ࢻ࡛࠶ࡿș-࢝ࣟࢸࣥࡢᙳ㡪࡟㛵ࡋ࡚ゎᯒࢆ⾜ࡗࡓࠋࡉࡽ࡟ࠊᨺᑕ⥺࡟ࡼࡿ⏕యศᏊᦆയ࠾
ࡼࡧ㧗࠸ᨺᑕ⥺᢬ᢠᛶࢆ᭷ࡍࡿ⏕≀ࡢ⏕య㜵ᚚᶵᵓࢆ in vivo ࡛ゎ᫂ࡍࡿࡓࡵ࡟ࠊ௦⾲ⓗ࡞⣽⳦࡛࠶ࡿ኱
⭠⳦࡟Ț⥺ࢆ⧞ࡾ㏉ࡋ↷ᑕࡍࡿࡇ࡜࡟ࡼࡾࠊȚ⥺ࢆ㑅ᢥᅽ࡜ࡋ࡚኱⭠⳦ࢆᐇ㦂ⓗࠊᣦྥⓗ࡟㐍໬ࡉࡏࠊᨺᑕ⥺⪏ᛶ኱⭠⳦ࡢసฟࢆ⾜ࡗࡓࠋ࠙᪉ἲࠚ⬡㉁ᦆയ࡟ᑐࡍࡿ࢝ࣟࢸࣀ࢖ࢻࡢᙳ㡪㸹㹙ヨᩱㄪ〇㹛
㸸5.0  10-1 M ࣜࣀࣞࣥ㓟࣋ࣥࢮࣥ⁐ᾮ࡬᭱⤊⃰ᗘ 5.0  10-6 ࠿ࡽ 8.5  10-3 M ࡜࡞ࡿࡼ࠺
࡟ș-࢝ࣟࢸࣥࢆ⁐ゎࡉࡏࠊș-࢝ࣟࢸࣥῧຍࣜࣀࣞ
ࣥ㓟࣋ࣥࢮࣥ⁐ᾮࢆㄪ〇ࡋࡓࠋ㹙Ț⥺↷ᑕ㹛㸸ㄪ〇⁐
60ᾮ࡟ᑐࡋ࡚ CoȚ⥺ࢆ⥺㔞⋡ 400 Gy/minࠊ✵Ẽ㞺ᅖẼୗࠊᐊ 㸦25Υ㸧࡛ 30 kGy ↷ᑕࡋࡓࠋ㹙ࣜࣀࣞࣥ㓟ᦆയࡢゎᯒ㹛㸸Ț⥺↷ᑕ࡟ࡼࡿࣜࣀࣞࣥ㓟ᦆയࡢ⛬ᗘࡣࠊࣜࣀࣞࣥ㓟ࡢ㓟໬ⓗศゎࡢ⤖ᯝ⏕ᡂࡍࡿmalondialdehyde 㔞ࢆࠊTBA ẚⰍἲࢆ⏝࠸࡚ᐃ㔞ࡍࡿࡇ࡜࡟ࡼࡾホ౯ࡋࡓࠋᨺᑕ⥺⪏ᛶ኱⭠⳦ࡢసฟ㸹㹙኱⭠⳦࡟ᑐࡍࡿȚ⥺࡟ࡼࡿ㑅ᢥ㹛㸸኱⭠⳦ࢆ LB ᇵᆅ୰ࠊ37Υ࡛ early log phase ࡲ࡛ቑṪࡉࡏࠊᇵᆅࢆ PBS()࡛⨨᥮ࡋࡓᚋࠊ⥺㔞⋡ 25 Gy/minࠊᐊ 㸦25Υ㸧࡛ࡑࡢ኱⭠⳦ࡢ 1㸣ࡢ⏕Ꮡ⋡ࢆ୚࠼ࡿ⥺㔞㸦D1 ⥺㔞㸧ࡢȚ⥺ࢆ↷ᑕࡋࡓࠋࡉࡽ࡟ࠊ⏕Ꮡ኱⭠⳦ࡢȚ⥺࡟ᑐࡍࡿឤཷᛶࢆ☜ㄆࡋ D1 ⥺㔞ࢆồࡵࠊࡇࢀࡽࡢ᧯సࢆ⧞
ࡾ㏉ࡋࡓࠋ㹙኱⭠⳦ࡢȚ⥺࡟ᑐࡍࡿឤཷᛶࡢ☜ㄆ㹛㸸Ț⥺↷ᑕ࡟ࡼࡿ㑅ᢥ᧯స࡟ࡼࡗ࡚ᚓࡽࢀࡓ኱⭠⳦ࢆ

early log phase ࡲ࡛ቑṪࡉࡏࠊୖ㏙ࡢࡼ࠺࡟Ț⥺↷ᑕࢆ⾜ࡗࡓࠋ↷ᑕ኱⭠⳦ᠱ⃮ᾮࢆ㐺ᙜ࡟ᕼ㔘ᚋࠊLB ࢔࣮࢞ࣉ࣮ࣞࢺ࡟ࣉ࣮ࣞࢸ࢕ࣥࢢࡋࠊ࣮࢜ࣂ࣮ࢼ࢖ࢺࠊ
37Υ࡛࢖࣮ࣥ࢟ࣗ࣋ࢺࢆࡋࡓᚋࠊ⏕ᡂࢥࣟࢽ࣮ᩘࢆ
࢝࢘ࣥࢺࡋ⏕Ꮡ᭤⥺ࢆồࡵࠊ㑅ᢥ኱⭠⳦ࡢ D1 ⥺㔞࠾ࡼࡧ୍⯡ⓗ࡟⏕≀ࡢᨺᑕ⥺࡟ᑐࡍࡿឤཷᛶࡢᣦᶆ࡜
ࡋ࡚⏝࠸ࡽࢀࡿ D37 ⥺㔞㸦37㸣ࡢ⏕Ꮡ⋡ࢆ୚࠼ࡿ⥺㔞㸧ࢆ⟬ฟࡋࡓࠋ
࠙⤖ᯝ࡜⪃ᐹࠚᮏᐇ㦂⣔࡟࠾࠸࡚ 8.5  10-3 M ࡢș-࢝ࣟࢸࣥࡣȚ⥺↷ᑕ࡟ࡼࡿࣜࣀࣞࣥ㓟ࡢ㓟໬ⓗศゎࢆ᭷ព࡟ᢚไࡋࡓࠋ୍᪉ࠊ5.0  10-5 Mࠊ5.0 
10-6 M ࡢș-࢝ࣟࢸࣥࡣࣜࣀࣞࣥ㓟ࡢ㓟໬ⓗศゎࢆ᭷ព࡟ಁ㐍ࡋࡓࠋࡇࢀࡽࡢࡇ࡜ࡼࡾࠊȚ⥺↷ᑕ࡟ࡼࡿࣜࣀࣞࣥ㓟ࡢ㓟໬ⓗศゎ཯ᛂ࡟ᑐࡋ࡚ࠊ࢝ࣟࢸࣀ
࢖ࢻࡣ᮲௳࡟ࡼࡗ࡚㜵ㆤຠᯝ࠶ࡿ࠸ࡣಁ㐍ຠᯝࢆ♧ࡍࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ[4]ࠋࡉࡽ࡟ࠊᮏᐇ㦂᮲௳࡟࠾ࡅࡿȚ⥺࡟ࡼࡿ኱⭠⳦ࡢ㑅ᢥ࡟࠾࠸࡚ࠊ5̾ 6 ᅇࡢ㑅ᢥ᧯సᚋ࡟ᚓࡽࢀࡓ኱⭠⳦ࡢȚ⥺࡟ᑐࡍࡿ⪏ᛶᗘ࡟ୖ᪼ഴྥࡀㄆࡵࡽࢀࡓ㸦Fig. 1㸧ࠋࡉࡽ࡟ࠊ8 ᅇࡢ㑅ᢥ᧯స࡟ࡼࡗ࡚ᚓࡽࢀࡓ኱⭠⳦㞟ᅋࡢȚ⥺࡟ᑐࡍࡿ⪏ᛶᗘࡣࠊ㔝⏕ᆺ኱⭠⳦ࡢࡑࢀ࡜ẚ㍑ࡋ࡚ 3.4 ಸ࡟ୖ᪼ࡋࡓ㸦Fig. 1㸧ࠋᮏ◊✲࡟ࡼࡾࠊᨺᑕ⥺⪏ᛶ⣽⳦⣽⬊୰࡟࠾࠸࡚࢝
ࣟࢸࣀ࢖ࢻࡣȚ⥺↷ᑕ࡟ࡼࡿ⣽⬊⭷ᵓᡂ⬡㉁࠾ࡼࡧ
⺮ⓑ㉁➼ࡢ⏕యศᏊᦆയ࡟ᑐࡋ࡚㜵ㆤⓗ࡟ᶵ⬟ࡍࡿ㓄ิࡢ㸯ḟᵓ㐀ཬࡧ㸰ḟᵓ㐀࡛኱ࡁࡃᙳ㡪ࡉࢀࠊ≉ᐃࡢṧᇶ࡛ࡢࡳ㉳ࡇࡿࠋᡃࠎࡣ୍⯡ⓗ࡞ HPLC ἲ࡛⡆౽࡟ᵓ㐀ኚ໬ࡋࡓ࢔࣑ࣀ㓟ṧᇶࢆᐃ㔞ࡍࡿ᪉ἲࢆ
☜❧ࡋࡓ㹙5,6㹛ࠋAsp ṧᇶࡣ L-ࢧࢡࢩࣥ࢖࣑ࢻయ࡬
ࡢ㛢⎔࡟⥆ࡁࠊL-ࢧࢡࢩࣥ࢖࣑ࢻయ࠿ࡽࡢ㛤⎔࡟ࡼࡾ࢖ࢯ࢔ࢫࣃࣛࢠࣥ㓟ṧᇶ࡟ᵓ㐀ኚ໬ࡍࡿࠋ཯ᛂᶵ
ᵓࡢヲ⣽࡞ゎᯒ࡟ࡣࢧࢡࢩࣥ࢖࣑ࢻ୰㛫యࢆࡶࡘ࣌
ࣉࢳࢻࢆฟⓎᮦᩱ࡜ࡋ࡚ᐇ㦂ࡍࡿᚲせࡀ࠶ࡿࡀࠊࢧ
ࢡࢩࣥ࢖࣑ࢻ୰㛫యࡣᐜ᫆࡟㛤⎔ࡍࡿࡓࡵྲྀࡾᢅ࠸
ࡀᅔ㞴࡛࠶ࡾ㸪ྜᡂရࡢ฼⏝ࡀไ㝈ࡉࢀࡿ㸬ᵓ㐀ኚ໬ࢆಟ᚟ࡍࡿ㓝⣲ Protein L-isoaspartyl methyltransferase(PIMT)ࡣᵓ㐀ኚ໬ࡋࡓ Asp ṧᇶ㸦L-isoAsp㸧ࢆ࣓ࢳࣝ໬ࡍࡿࡇ࡜࡛ࢧࢡࢩࣥ࢖࣑ࢻయࡢᙧᡂࢆಁ㐍ࡉࡏࠊ୰㛫య࠿ࡽࡢ㛤⎔཯ᛂࡢࢱ࣮࣮ࣥ࢜ࣂ࣮ࢆ㏿ࡵࡿࡇ࡜࡛ࠊඖࡢ Asp ṧᇶࡢᵓ㐀㸦L-Asp㸧࡟ಟ᚟ࡍ
ࡿࠋ㸦Fig.2㸧

Fig. 2 PIMT repair system for L-isoAsp residue

Fig. 1. Increase in radioresistance of E. coli
during selection by gamma irradiation.
ࡇ࡜࡟ࡼࡾࡑࡢ⏕య㜵ㆤᶵᵓ࡟ᐤ୚ࡋ࡚࠾ࡾࠊࡉࡽ
࡟⣽⬊୰ࡢ࢝ࣟࢸࣀ࢖ࢻ⃰ᗘࡣཝᐦ࡟ไᚚࡉࢀ࡚࠸
ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡲࡓࠊȚ⥺ࡀ㑅ᢥᅽ࡜࡞ࡗࡓ
᫬ࠊ኱⭠⳦ࡣȚ⥺࡟ᑐࡍࡿ㧗࠸⪏ᛶᗘࢆ㐍໬ⓗ࡟⋓ᚓࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ௒ᚋࠊ࢝ࣟࢸࣀ࢖ࢻ
➼࡟ࡼࡿᢠ㓟໬άᛶ࡟ὀ┠ࡋࡘࡘࠊᚓࡽࢀࡓȚ⥺⪏ᛶ኱⭠⳦ࡶ⏝࠸ࠊin vivo ࡟࠾ࡅࡿᨺᑕ⥺࡟ࡼࡿ⏕యศᏊᦆയ࡜ᨺᑕ⥺࡟ᑐࡍࡿ⏕య㜵ᚚᶵᵓࡢゎ᫂ࢆ㐍ᒎࡉࡏ࡚࠸ࡃࡇ࡜ࡀᚲせ࡛࠶ࡿࠋ4㸧⺮ⓑ㉁୰ࡢ࢔ࢫࣃࣛࢠࣥ࠾ࡼࡧ࢔ࢫࣃࣛࢠࣥ㓟ṧᇶࡢ␗ᛶ໬࡜ᶵ⬟ኚ໬࡟㛵ࡍࡿ◊✲㸦‫ۑ‬ᐃ㔠㇏ࠊ⸨஭⣖Ꮚ㸧㹙┠ⓗ㹛Asp ࡜ Asn ṧᇶࡣࢧࢡࢩࣥ࢖࣑ࢻయࢆᙧᡂ
ࡋࡸࡍ࠸ࡓࡵ⺮ⓑ㉁୰࡛ࡶᵓ㐀ࡀኚ໬ࡋࡸࡍ࠸࢔࣑
ࣀ㓟ṧᇶ࡜ࡋ࡚▱ࡽࢀ࡚࠸ࡿࠋᵓ㐀ኚ໬ࡣ࢔࣑ࣀ㓟㻙 䢵㻌㻙

PIMT ࡣ L-isoAsp ṧᇶࡢഃ㙐ࡢ࢝ࣝ࣎ࣥ㓟ࢆ࣓ࢳࣝ໬ࡍࡿࡇ࡜࡛ࢧࢡࢩࣥ࢖࣑ࢻయ࡬ࡢኚ᥮ࢆຍ㏿ࡍࡿࠋ࣓ࢳࣝ໬ࡉࢀࡓ L-isoAsp ṧᇶࡢ㛢⎔ࡣ㸪ࢧࢡࢩࣥ࢖࣑ࢻయ࠿ࡽࡢ㛤⎔࡟ẚ࡭࡚࠿࡞ࡾ㏿࠸ࡢ࡛ࠊ⤖ᯝ࡜ࡋ࡚ࢧࢡࢩࣥ࢖࣑ࢻ୰㛫యࢆࡶࡘ࣌ࣉࢳࢻࢆస
ᡂࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋᮏ◊✲࡛ࡣࠊPIMT ಟ᚟㓝⣲ࢆ฼⏝ࡋ࡚ᵓ㐀ኚ໬㐣⛬ࡢ㛢⎔཯ᛂ࡜㛤⎔཯ᛂ࡜ࢆษ
ࡾศࡅ࡚ゎᯒࡍࡿ᪉ἲࢆ☜❧ࡋࠊAsp ṧᇶࡢ C ᮎഃࡢ࢔࣑ࣀ㓟ṧᇶࡀ␗࡞ࡿ࡜ࡁࡢᙳ㡪ࢆヲ⣽࡟ゎᯒࡋࡓࠋࡇࡢ௚࡟ࡶග཯ᛂᇶࢆ฼⏝ࡋࡓᵓ㐀ゎᯒἲࡢ☜❧࠾ࡼࡧㄆ▱⑕࡜ࡢ㛵㐃ㄪᰝࢆᐇ᪋ࡋࠊ␗ᛶ໬⺮ⓑ㉁ࡢᶵ⬟㞀ᐖࢆㄪ࡭ࡿᇶ♏ⓗ◊✲ࡶ⾜ࡗࡓ㹙7,8㹛ࠋ㹙᪉ἲ㹛ࣛࢵࢺ PIMT ࡢ N ᮎ࡟ His ࢱࢢࢆᣢࡘ⤌᥮
࠼ PIMT 㑇ఏᏊࢆᙧ㉁㌿᥮ࡋࡓ኱⭠⳦ࢆ฼⏝ࡋ࡚ࠊ⤌᥮࠼ࣛࢵࢺ PIMT ࢆⓎ⌧ࡋࡓࠋࡑࡢᚋࠊࢽࢵࢣࣝ
ࣞࢪ࣭ࣥ࢔ࣇ࢕ࢽࢸ࢕࣮ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࡛ PIMTࢆ⢭〇ࡋࠊ㏱ᯒ࡛⃰⦰ࡋࡓࡶࡢࢆ␗ᛶ໬ಟ᚟㓝⣲࡜ࡋ࡚฼⏝ࡋࡓࠋAsp ṧᇶࡢ C ᮎഃࡢ࢔࣑ࣀ㓟ṧᇶࢆ
SerࠊAlaࠊLeu ࡜ࡋࡓ 3 ✀㢮ࡢ࣌ࣉࢳࢻྜᡂࡋࠊゎᯒࡢࣔࢹࣝ࣌ࣉࢳࢻ࡜ࡋࡓࠋࡑࢀࡒࢀࡢ࣌ࣉࢳࢻࢆ୍
ᐃ᫬㛫 PIMT ࡛ฎ⌮ࡋࡓᚋࠊ㝈እࢁ㐣࡛ PIMT ࢆ㝖ཤࡋࠊࢧࢡࢩࣥ࢖࣑ࢻయࢆࡶࡘ࣌ࣉࢳࢻࢆసᡂࡋࡓࠋ
Asp ṧᇶࡢ␗ᛶయࢆྠ᫬࡟ゎᯒ࡛ࡁࡿ HPLC ศᯒἲࢆ☜❧ࡋࠊ࣌ࣉࢳࢻ୰ࡢ Asp ṧᇶࡢᵓ㐀ኚ໬ࢆ⤒᫬ⓗ࡟ᐃ㔞ࡋࡓࠋ㛤⎔࣭㛢⎔཯ᛂ࡛ࡢྛ⏕ᡂ㔞ࢆࢢࣛࣇ໬ࡋࠊࡑࡢࢢࣛࣇࡼࡾ཯ᛂ㏿ᗘᐃᩘࢆỴᐃࡋࡓࠋ㹙⤖⤖ᯝ࡜⪃ᐹ㹛PIMT άᛶࡣ S-࢔ࢹࣀࢩ࣓ࣝࢳ࢜ࢽ
ࣥ࠿ࡽ࣓ࢳࣝᇶࢆ౪୚ࡋࡓ㔞࡛ ᐃ࡛ࡁࡿࡢ࡛ࠊ
HPLC ࡛ S-࢔ࢹࣀࢩࣝ࣍ࣔࢩࢫࢸ࢖ࣥ㸦SAH㸧ࡢ⏕ᡂ㔞ࢆ ᐃࡋࡓࠋᵝࠎ࡞㛗ࡉࡢ࣌ࣉࢳࢻ㙐ࢆྜᡂࡋࠊ
ࡑࢀࡽࢆᇶ㉁࡜ࡋࡓάᛶࢆ ᐃࡋࡓ㸦Fig.3㸧ࠋṧᇶᩘࡀ㛗࠸࡯࡝άᛶࡣ㧗࠸ࡶࡢࡢࠊ7 ṧᇶ⛬ᗘ࡛༑ศ࡞
άᛶࡀᚓࡽࢀࡓࡢ࡛ࠊᮏ◊✲࡛ࡣ LLADXLY ࡢ 7 ṧᇶࡢࣔࢹࣝ࣌ࣉࢳࢻ࡜ࡋ࡚฼⏝ࡋࡓࠋࣔࢹࣝ࣌ࣉࢳ
ࢻࢆ PIMT ࡜཯ᛂࡉࡏࠊL-isoAsp ṧᇶࡀࢧࢡࢩࣥ࢖
࣑ࢻయ࡜࡞ࡿ㐣⛬ࢆ⤒᫬ⓗ࡟ HPLC ࡛ゎᯒࡋࠊࢧࢡ
ࢩࣥ࢖࣑ࢻయࡀ༑ศ࡟Ꮡᅾࡍࡿ᮲௳ࢆỴᐃࡋࡓࠋ㝈እࢁ㐣ᚋࡢࢧࢡࢩࣥ࢖࣑ࢻయࡀ㛤⎔ࡋ Asp࣭isoAsp
ṧᇶࡀቑຍࡍࡿࢢࣛࣇࡢ㏆ఝᘧࡼࡾࠊ㛤⎔㏿ᗘᐃᩘࢆỴᐃࡋࡓࠋ

Fig. 3 Effect of peptide length on PIMT activityࡑࡢ⤖ᯝࠊAsp ṧᇶࡢ C ᮎഃࡀ Ser ࡢሙྜࡣ Leu࡟ẚ࡭⣙ 4㸫5 ಸࠊAla ࡢሙྜࡣ Leu ࡟ẚ࡭⣙ 2 ಸࡢ㏿ࡉ࡛㛤⎔ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋࡲࡓࠊ㛢⎔࣭㛤⎔཯ᛂࡢ㏿ᗘᐃᩘࢆẚ㍑ࡋࡓ࡜ࡇࢁࠊAla ࡜ Leuࡣࠊ㛢⎔࣭㛤⎔཯ᛂ࡜ࡶ࡟➼౯࡟ᙳ㡪ࢆ୚࠼࡚࠾ࡾࠊ
Ser ࡣ㛢⎔཯ᛂࡼࡾࡶ㛤⎔཯ᛂ࡟኱ࡁࡃᙳ㡪ࢆ୚࠼࡚࠸ࡓࡇ࡜ࡀࢃ࠿ࡗࡓࠋᮏ◊✲ࡢ␗ᛶ໬ಟ᚟㓝⣲PIMT ࢆ฼⏝ࡍࡿ᪉ἲㄽࡢ㛤Ⓨ࡟ࡼࡾࠊ㛢⎔࡜㛤⎔⌧㇟࡜ࢆษࡾศࡅ࡚ゎᯒࡋࠊࡑࡢ⤖ᯝ C ᮎ➃ഃ࢔࣑ࣀ㓟ṧᇶࡀཬࡰࡍྛ཯ᛂ࡬ࡢᙳ㡪ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
࢔࣑ࣀ㓟ṧᇶࡢഃ㙐ࡢ࠿ࡉ㧗ࡉ࡟ࡼࡿᙳ㡪ࡣࠊ㛤⎔࣭㛢⎔཯ᛂ࡟➼౯࡟ᙳ㡪ࡋࡓࠋSer ࡀ㛤⎔཯ᛂ࡬ࡼࡾ኱ࡁࡃᙳ㡪ࡋࡓࡢࡣࠊ⮬⏤ᅇ㌿ࡀྍ⬟࡞㛤⎔≧ែ࡜ࠊᖹ㠃ᵓ㐀ࢆ࡜ࡿࢧࢡࢩࣥ࢖࣑ࢻయ࡛࠶ࡿ㛢⎔≧ែ࡜ࡢࠊᵓ㐀ࡢ㐪࠸࡟㉳ᅉࡋ࡚࠸ࡿࡢࡔ࡜⪃࠼ࡓࠋ
Asp ṧᇶࡢᵓ㐀ኚ໬ࢆࡼࡾヲ⣽࡟ゎᯒ࡛ࡁࡿࡼ࠺࡟
࡞ࡿ஦࡛ࠊ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢࡼ࠺࡟ Asp ṧᇶࡢᵓ㐀ኚ໬࡜ࡢ㛵㐃ࡀᣦ᦬ࡉࢀ࡚࠸ࡿ⑌⑓ࢆ῝ࡃ⪃ᐹ࡛ࡁࡿࡼ࠺࡟࡞ࡿ࡜ᮇᚅࡍࡿࠋ
㸧㦁㡢ࢫࢺࣞࢫ࡟ࡼࡿෆ⪥⺮ⓑ㉁୰ࡢ࢔ࢫࣃࣛࢠࣥ
㓟ṧᇶࡢ␗ᛶ໬ࡢゎᯒ㸦‫ۑ‬኱⚄ಙᏕࠊ⸨஭⣖Ꮚ㸧㸯㸬㦁㡢ࢫࢺࣞࢫ࡜ෆ⪥㞀ᐖࡢゎᯒ[⫼ᬒ࣭┠ⓗ] 㦁㡢ࡣ࿘Ἴᩘ㸦࣊ࣝࢶ㸹Hz㸧࡜㡢㔞㸦ࢹࢩ࣋ࣝ㸹dB㸧࡟ࡼࡾ⾲ࡉࢀࡿ≀⌮ⓗ⎔ቃᅉᏊ࡛࠶ࡿࠋ
㦁㡢ᛶ㞴⫈ࡀㄏⓎࡉࢀࡿ㦁㡢ࡢ༴㝤ᛶࡣ୺࡟㡢㔞࡟㻙 䢶㻌㻙ࡼࡾゎᯒࡉࢀ࡚࠸ࡿࡀࠊ࿘Ἴᩘࡢせ⣲ࡶຍ࠼࡚ゎᯒࡋࡓ㦁㡢ࡢ༴㝤ᛶࡢ᝟ሗࡣ㝈ࡽࢀ࡚࠸ࡿࠋ㏆ᖺࠊ㢼ຊⓎ㟁ࠊ࢚ࢥ࣮࢟ࣗࢺࠊ࠶ࡿ࠸ࡣ✵ㄪᶵჾࡢᐊእᶵ
࡞࡝ᵝࠎ࡞ᶵჾ࠿ࡽⓎ⏕ࡍࡿࠕప࿘Ἴ㦁㡢ࠖ࡟ࡼࡿ೺ᗣ⿕ᐖࡀ♫఍ၥ㢟໬ࡋ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊప
࿘Ἴ㦁㡢ࡢලయⓗ࡞೺ᗣࣜࢫࢡ࡟ࡘ࠸࡚ࡣ᫂ࡽ࠿࡟
࡞ࡗ࡚࠾ࡽࡎࠊప࿘Ἴ㦁㡢࡟ᑐࡍࡿண㜵࣭㜵ᚚἲࡣᮍࡔ㛤Ⓨࡉࢀ࡚࠸࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋప࿘Ἴ㦁㡢ࡣ 100 Hz ௨ୗࡢ࿘Ἴᩘࢆᣢࡘ㦁㡢࡜ᐃ⩏ࡉࢀࠊࡑࡢ
࿘Ἴᩘࡣࣄࢺࡢྍ⫈ᇦ㸦20~20,000 Hz㸧࡟ࡣ㒊ศⓗ࡟࣮࢜ࣂ࣮ࣛࢵࣉࡍࡿࡀࠊ࣐࢘ࢫࡢྍ⫈ᇦ
㸦1,000~40,000 Hz㸧࡟ࡣ඲ࡃ㔜࡞ࡽ࡞࠸ࠋᡃࠎࡀᙜ
ᩍᐊࡢᐇ㦂ᐊෆࡢᶵჾ࠿ࡽⓎ⏕ࡍࡿ㦁㡢ࡢ㡢㔞࡜࿘Ἴᩘࢆ ᐃࡋࡓᡤࠊࣇ࣮ࣜࢨ࣮ࠊࢻࣛࣇࢺࠊ࢚࢔ࢥ
ࣥࡸ᥮Ẽᡪ➼ࡢṤ࡝ࡢᶵჾ࠿ࡽ 100 Hz ࡢ࿘Ἴᩘࢆ
ࣆ࣮ࢡ࡜ࡍࡿప࿘Ἴ㦁㡢ࡀ⣙ 70 dB ࡢ㡢㔞࡛Ⓨ⏕ࡋ࡚࠸ࡿ஦ࡀศ࠿ࡗࡓࠋࡑࡇ࡛ࠊᡃࠎࡢ ᐃ್ࠊ࠾ࡼ
ࡧࣄࢺࡢ㔜ᚰືᦂ࡜㉸ప࿘Ἴ㡢㸦20 Hz ௨ୗ㸧ࡢ㛵㐃ࢆゎᯒࡋࡓ㐣ཤࡢሗ࿌ࢆཧ⪃࡟ࠊᡃࠎࡣప࿘Ἴ㦁
㡢㸦100 Hzࠊ70 dB㸧᭚㟢ࡢᖹ⾮ឤぬ࡬ࡢᙳ㡪ࢆゎᯒࡍࡿᐇ㦂◊✲ࢆᐇ᪋ࡋࡓࠋ
[᪉ἲ] 㔝⏕ᆺ࣐࢘ࢫ࡟ప࿘Ἴ㦁㡢ࢆ 1 ࣨ᭶⛬ᗘ᭚㟢ࡋࠊ࣮ࣟࢱ࣮ࣟࢵࢻࠊᖹᆒྎṌ⾜ヨ㦂ࠊṌ⾜ࣃࢱ࣮ࣥゎᯒ࡞࡝ࡢ⾜ືゎᯒ࡟ࡼࡾᖹ⾮ឤぬ࡟୚࠼ࡿᙳ㡪ࢆゎᯒࡋࡓࠋ
[⤖ᯝ࣭⪃ᐹ] ప࿘Ἴ㦁㡢᭚㟢⩌ࡣࠊ㠀᭚㟢⩌ཬࡧ㧗࿘Ἴ㡢㸦16,000 Hz㸧᭚㟢⩌࡜ẚ㍑ࡋ࡚ᡂ⦼ࡀ᭷ព࡟
పୗࡍࡿ஦ࡀศ࠿ࡗࡓࠋࡲࡓࠊෆ⪥ࡢ๓ᗞࢆᶆⓗ⮚ჾ࡜ࡋ࡚ᙧែゎᯒࢆᐇ᪋ࡋࡓᡤࠊ᭚㟢⩌࡛ࡣ
calbindin-D28k 㝧ᛶ⣽⬊ᩘࡀῶᑡࡋࡓࠋࡉࡽ࡟ࠊ㓟໬ࣜࣥ⬡㉁ᢠయࠊD-E-Asp ᢠయࢆ⏝࠸ࡓච␿⤌⧊ᰁⰍ࡛ࡣࠊ㠀᭚㟢⩌࡜ẚ㍑ࡋ࡚ࠊప࿘Ἴ㦁㡢᭚㟢⩌ࡣ๓ᗞࡢ㎶⦕㒊࡟࠾࠸࡚ࠊᙉ࠸㝧ᛶീࡀほᐹࡉࢀࡓࠋ௨
ୖࡢ⤖ᯝࡼࡾࠊప࿘Ἴ㦁㡢ࡣෆ⪥๓ᗞࡢ㞀ᐖࢆ௓ࡋ࡚ᖹ⾮ឤぬ㞀ᐖࢆㄏⓎࡍࡿ஦ࡀ♧၀ࡉࢀࡓ[9]ࠋ௒ᚋ
ࡣࠊ࣐࢘ࢫࢆᑐ㇟࡜ࡋࡓప࿘Ἴ㦁㡢ࡢ೺ᗣࣜࢫࢡホ౯ἲࢆ⏝࠸࡚ࠊ᭚㟢㔞ࠊ᭚㟢᫬ᮇ➼ࡢ㐪࠸࡟ࡼࡿឤ
ཷᛶࡢẚ㍑᳨ウࢆ㐍ࡵࡿ࡜ඹ࡟ࠊෆ⪥๓ᗞࡢண㜵࣭㜵ᚚἲࡢ㛤Ⓨࢆ㐍ࡵࡓ࠸ࠋ㸰㸬↓ᶵඖ⣲࡜ෆ⪥㞀ᐖࡢゎᯒ[⫼ᬒ࣭┠ⓗ] ᚲ㡲ඖ⣲ࡣ⏕యෆࡢ⺮ⓑ㉁࡞࡝ࡢᵓᡂ
ᡂศ࡜ࡋ࡚ࠊ࠶ࡿ࠸ࡣᾐ㏱ᅽࡸ⚄⤒ఏ㐩ࡢㄪ⠇ᅉᏊ࡜ࡋ࡚㔜せ࡞ᙺ๭ࢆᢸ࠺ࠋ㕲ࠊ㖡ࠊ࣐ࣥ࢞ࣥ➼ࡢඖ⣲ࡣ㓝⣲࡞࡝ࡢ❧యᵓ㐀࣭άᛶࡢ⥔ᣢ࡟ᚲ㡲ࡢᅉᏊ࡛࠶ࡿࡀࠊ㐣๫ᦤྲྀࡣ⚄⤒ኚᛶ࡞࡝ࡢ୰ẘ⑕≧ࢆᘬࡁ㉳ࡇࡍࠋ୍᪉ࠊ㰘⭷ࡢዟ࡟఩⨨ࡍࡿෆ⪥ࡢ⫈⚄⤒ࡢኚᛶ➼࡟ࡼࡾⓎ⑕ࡍࡿឤ㡢ᛶ㞴⫈ࡣࠊࡑࡢ⑓
ᅉ࡜ࡋ࡚ࠊ㑇ఏⓗせᅉࠊຍ㱋࠶ࡿ࠸ࡣ⎔ቃᅉᏊࡀ」ྜⓗ࡟㛵ࢃࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡀࠊ㣗஦ࡸ㣧ᩱỈ⏤᮶ࡢඖ⣲ࡢᦤྲྀ㔞࡜⫈ຊࡢ㛵㐃ࡣṤ࡝ศ࠿ࡗ࡚࠸࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋ㐣ཤࡢሗ࿌࡟ࡼࡿ࡜ࠊ࣋
ࢺࢼ࣒ࡸࣂࣥࢢࣛࢹࢩࣗ➼ࡢᅜࠎࡢ㣧⏝஭ᡞỈ࡟ࣂ
࣒ࣜ࢘㸦Ba㸧ࡀ WHO 㣧⏝Ỉ࢞࢖ࢻࣛ࢖್ࣥୖ㝈㸦0.7

mg/L㸧௨ୖࡢ᳨࡛ࣞ࣋ࣝฟࡉࢀࠊ㣧ᩱỈ⏤᮶ࡢ Baࡢ೺ᗣ࡬ࡢࣜࢫࢡࡀᠱᛕࡉࢀ࡚࠸ࡿ[10,11]ࠋࡲࡓࠊ
⾑⟶℺ὶἲ࡟ࡼࡾሷ໬ࣂ࣒ࣜ࢘㸦BaCl2㸧ࢆෆ⪥࡟┤᥋ᢞ୚ࡍࡿ࡜ࠊෆ⪥ࡢ K+ࢳࣕࣥࢿࣝࢆ㜼ᐖࡋෆࣜࣥࣃ㟁఩␗ᖖࢆㄏⓎࡍࡿ஦ࡀሗ࿌ࡉࢀ࡚࠸ࡿ[12]ࠋ
ࡋ࠿ࡋ࡞ࠊ㣧Ỉᢞ୚ࡋࡓ Ba ࡢ⫈ຊࣞ࣋ࣝ࡟୚࠼ࡿ
ᙳ㡪ࡣ඲ࡃศ࠿ࡗ࡚࠸࡞࠸ࠋࡑࡇ࡛ᮏ◊✲ࡣࠊBaࢆ࣐࢘ࢫ࡟㣧Ỉᢞ୚ࡋࠊ⫈ぬ⣔࡟୚࠼ࡿᙳ㡪ࢆゎᯒࡋࡓࠋ[᪉᪉ἲ] 㔝⏕ᆺ࣐࢘ࢫ࡟ WHO 㣧⏝Ỉ࢞࢖ࢻࣛ࢖್ࣥ
ࡢୖ㝈㸦0.7 mg/L㸧࡟┦ᙜࡍࡿ⏝㔞ࡢ BaCl2 ࢆ㣧Ỉᢞ୚ࡋࠊICP-MS ࢆ⏝࠸࡚ Ba ࡢయෆ⤌⧊ศᕸࡢゎᯒ࠾ࡼࡧ⫈ᛶ⬻ᖿ཯ᛂ ᐃ[13]ࢆᐇ᪋ࡋࡓࠋ
[⤖ᯝ࣭⪃ᐹ] ୰ᯡ⚄⤒⣔࡞࡝୺せ⤌⧊࡛ࡣ Ba ࡣ᳨ฟࡉࢀ࡞࠿ࡗࡓࡀࠊᢞ୚⩌ࡢෆ⪥࡛ࡣࠊ㠀ᢞ୚⩌࡜ẚ㍑ࡋ࡚ࠊBa ⵳✚㔞ࡀ᭷ព࡟ቑຍࡋࡓࠋ᭦࡟ࠊᢞ୚
⩌࡛ࡣ⫈ຊపୗࢆᣍࡁࠊෆ⪥ࢥࣝࢳჾࡢ୺せ㒊఩࡛࠶ࡿ᭷ẟ⣽⬊ࠊ⾑⟶᮲࠾ࡼࡧࣛࢭࣥ⚄⤒⠇࡟࠾࠸࡚ᑒධయᵝࡢኚᛶീࢆ♧ࡍ஦ࡀศ࠿ࡗࡓ[14]ࠋ᭦࡟ࣄࢺ
ࢆᑐ㇟࡟ࡋࡓ␿Ꮫ◊✲࡟ࡼࡾࠊ⏕యෆࡢ Ba ࣞ࣋ࣝࢆ⫈ぬ㞀ᐖ࡟᭷ព࡞┦㛵ࡀ࠶ࡿ஦ࡀࢃ࠿ࡗࡓ[15]ࠋ௒
ᚋࠊෆ⪥ࡢ⫈⚄⤒ኚᛶࢆㄏⓎࡍࡿ௚ࡢඖ⣲ࢆ᥈⣴ࡍࡿ࡜ඹ࡟ࠊୖ㏙ࡋࡓᑒධయᵝࡢኚᛶ㒊఩࡟Ꮡᅾࡍࡿ
␗ᖖจ㞟⺮ⓑ㉁ࡢྠᐃࢆ㐍ࡵࡓ࠸ࠋ㸧⺮ⓑ㉁୰ࡢ࢔ࢫࣃࣛࢠࣥ㓟ṧᇶࡢ␗ᛶయศᯒ᪉ἲ
ࡢ㛤Ⓨ㸦‫⸨ۑ‬஭ᬛᙪࠊᓊᮏᡂྐࠊ⸨஭⣖Ꮚ㸧࠙⫼ᬒ࣭┠ⓗࠚຍ㱋ᛶⓑෆ㞀࡛ࡣỈᬗయ⺮ⓑ㉁୰ࡢ
࢔ࢫࣃࣛࢠࣥ㓟 (Lα-Asp)ṧᇶࡢ୍㒊ࡀ␗ᛶ໬(Lβ-,Dα-, Dβ-Asp)ࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣ
௨๓࡟ࡑࡢ Asp ṧᇶࡢ㒊఩ࡸ␗ᛶయࢆྠᐃࡍࡿ᪉ἲ
࡜ࡋ࡚ࠊᾮయࢡ࣐ࣟࢺࢢࣛࣇ-ࢱࣥࢹ࣒ᆺ㉁㔞ศᯒ⿦⨨ (LC-MS/MS) ࢆ ౑ ⏝ ࡋ ࡓ ศ ᯒ ᪉ ἲ ࢆ 㛤 Ⓨ ࡋ ࡓ[16,17]ࠋࡇࡢ᪉ἲࡣ௨๓ࡢ␗ᛶయศᯒ᪉ἲ࡜ẚ㍑ࡍ
ࡿ࡜ศᯒ᫬㛫ࡀ㣕㌍ⓗ࡟▷⦰ࡉࢀࡓࠋࡋ࠿ࡋ
LC-MS/MS ἲ࡛ࡣ Asp ṧᇶࡢ␗ᛶ໬㒊఩ࡣ≉ᐃ࡛ࡁࡿࡀࠊ␗ᛶయࡢ✀㢮ࡢྠᐃཬࡧᐃ㔞ࢆ⾜࠺ࡓࡵ࡟ࠊ
ᶆရࡢ࣌ࣉࢳࢻࢆྜᡂࡍࡿ࠿ Asp ␗ᛶయ࡟≉␗ⓗ࡟཯ᛂࡍࡿ㓝⣲ࢆ౑⏝ࡋ࡞ࡅࢀࡤ࡞ࡽࡎࠊศᯒ࡟᫬㛫ࢆせࡋ࡚࠸ࡓࠋࡑࡇ࡛ᮏ◊✲࡛ࡣ␗ᛶయྠᐃ࡟せࡍࡿ᫬㛫ࢆ▷⦰ࡍࡿ᪉ἲ࡜ࡋ࡚ࠊ㉁㔞ศᯒࡢࡳ࡛ α-Asp
࠿ β-Asp ࠿ࢆྠᐃ࡛ࡁࡿ᪉ἲࢆ㛤Ⓨࡋࡓࠋ࠙᪉ἲࠚࣄࢺỈᬗయ⺮ⓑ㉁ࡢ αA-ࢡࣜࢫࢱࣜࣥࢆࢺ
ࣜࣉࢩࣥฎ⌮ࡋ࡚ᚓࡽࢀࡿ࢔࣑ࣀ㓟ṧᇶ 55-65 ␒┠(TVLDSGISEVR)࣌ࣉࢳࢻ(αAT6)ࡢ Asp 㒊ศࢆ Lα-,Lβ-, Dα-, Dβ-Asp ࡟ࡋࡓ࣌ࣉࢳࢻ(αAT6-Lα, αAT6-Lβ,
αAT6-Dα, αAT6-Dβ)ࢆ Fmoc ᅛ┦ྜᡂἲ࡛ྜᡂࡋࡓࠋ
ࡲࡓࠊຍ㱋ᛶⓑෆ㞀ࡢỈᬗయࡣ࣍ࣔࢪࢼ࢖ࢬᚋ࡟㐲ᚰศ㞳ࡋࠊỿẊ⏬ศࢆᒀ⣲࡛ྍ⁐໬ࡋ࡚࠿ࡽࢺࣜࣉ
ࢩࣥฎ⌮ࢆ⾜ࡗࡓࠋLC-MS/MS ࡣ LC 㒊ࡀ㏫┦ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮ࠊMS 㒊ࡀ MSn ࡢ ᐃࡀྍ⬟࡞࢖࢜ࣥࢺࣛࢵࣉᆺࢆ⏝࠸ࡓࠋ࠙⤖ᯝ࣭⪃ᐹࠚ Fig4 ࡣ αAT6 ࣌ࣉࢳࢻࡢ 2 ౯࢖࢜ࣥ(588.3 m/z)ࢆࣉ࣮ࣜ࢝ࢧ࣮࢖࢜ࣥ࡜ࡋࠊࡇࢀࢆ⾪✺㻙 䢷㻌㻙ㄏ㉳ゎ㞳(CID)ࡋ࡚⏕ᡂࡋࡓ y8 ࢖࢜ࣥ(862.6 m/z)ࢆࡉ
ࡽ࡟ CID ࡋࡓ(MS3)࣐ࢫࢫ࣌ࢡࢺ࡛ࣝ࠶ࡿࠋ
Fig 4-b, -dࡼࡾ αAT6-Lβ ࠾ࡼࡧ αAT6-Dβ ࡢࡳ y8-91 (771.6 m/z)
࠾ࡼࡧ y8-73 ࢖࢜ࣥ (789.6 m/z)ࡀ᳨ฟࡋࡓࠋࡲࡓࠊ
௚ࡢ࣌ࣉࢳࢻ࡛ࡶྠᵝ࡟ ᐃࡍࡿ࡜ β-Asp ࢆྵࡴ࣌ࣉࢳࢻࡢࡳ y(l-n+1)-91 ࠾ࡼࡧ y(l-n+1)-73 ࢖࢜ࣥ㸦࣌ࣉࢳࢻࡢ࢔࣑ࣀ㓟ṧᇶᩘࢆ lࠊN ➃ഃ࠿ࡽ n ␒┠ࡀ Asp
ṧᇶ࡜ࡍࡿ㸧ࡀ᳨ฟ࡛ࡁࡓࡢ࡛ࠊࡇࢀࡽ஧ࡘࡢ࢖࢜
ࣥࡢ᭷↓ࢆㄪ࡭ࡿࡇ࡜࡛ α-Asp ࠿ β-Asp ࡢุูࡀ࡛
ࡁࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ

Fig. 4 ᅄࡘࡢ Asp ␗ᛶయ αAT6 ࣌ࣉࢳࢻࡢ࣐ࢫࢫ࣌ࢡࢺࣝḟ ࡟ ࠊ α-Asp ࠿ β-Asp ࡢ ุ ู ࡀ ࡛ ࡁ ࡿ ᪉ ἲ ࢆ
LC-MS/MS ࢆ⏝࠸ࡓ␗ᛶయศᯒἲ࡟⤌ࡳ㎸ࢇ࡛ศᯒࢆ⾜ࡗࡓࠋFig5-a ࡣ 4 ࡘࡢ␗ᛶయ αAT6 ྜᡂ࣌ࣉࢳࢻ
ࢆ MS ᐃࡋࡓ αAT6 ࡢ 2 ౯࢖࢜ࣥ(588.3 m/z)ࡢ࣐ࢫ
ࢡ࣐ࣟࢺࢢ࣒࡛ࣛ࠶ࡾࠊFig5-b ࡣ αAT6 ྜᡂ࣌ࣉࢳࢻ
ࢆ MS3 ᐃࡋࡓ y8-73 ࢖࢜ࣥ(789.6 m/z)ࡢ࣐ࢫࢡ࣐ࣟ
ࢺࢢ࣒࡛ࣛ࠶ࡿࠋy8-73 ࢖࢜ࣥࡣ β-Asp ≉᭷࡞ࡢ࡛
αAT6-Lβ ࠾ࡼࡧ αAT6-Dβ ࡢࣆ࣮ࢡࡣ᳨ฟࡉࢀࡓࡀࠊ
αAT6-Lα ࠾ࡼࡧ αAT6-Dα ࡢࣆ࣮ࢡࡣ ᳨ ฟ ࡉ ࢀ ࡞ ࠿ࡗࡓࠋࡋࡓࡀࡗ࡚ࠊFig5-a ࡜ Fig5-b ࢆẚ㍑ࡍࡿࡇ࡜࡛ α-Asp ࠿ β-Asp ࡢྠᐃࡀྍ⬟࡜࡞ࡿࠋࡲࡓࠊຍ㱋ᛶⓑෆ㞀ࡢỈᬗయ࡛ࡶྠᵝ࡟ ᐃ(ᅗ 2-c, -d)ࡍࡿ࡜ 4ࡘࡢ␗ᛶయ αAT6 ྜᡂ࣌ࣉࢳࢻ࡜ྠᵝ࡞⤖ᯝࡀᚓࡽࢀࡓࠋ

Fig. 5 αAT6 ྜᡂ࣌ࣉࢳࢻ࠾ࡼࡧຍ㱋ᛶⓑෆ㞀ࡢỈᬗయࢆ LC-MS/MS ࢆ⏝࠸ࡓ␗ᛶయศᯒἲ࡛ ᐃࡋࡓ⤖ᯝLC-MS/MS ࢆ⏝࠸ࡓ␗ᛶయศᯒἲ࡟ᮏྠᐃ᪉ἲࢆ⤌ࡳ㎸ࢇ࡛ศᯒࢆࡍࡿ࡜ α-Asp ࠿ β-Asp ࡢྠᐃࡀྍ⬟࡛࠶ࡿࡇ࡜࠿ࡽࠊAsp ␗ᛶయྠᐃࡢ᫬㛫▷⦰ࡀྥୖࡍࡿ࡜⪃࠼ࡽࢀࡓࠋ

㸧αA-Cry 㒊ศ࣌ࣉࢳࢻ୰ࡢ Asp ␗ᛶయഃ㙐ࡢ❧య㓄ᗙゎᯒ࡜ Asp ␗ᛶయ㛫࡟࠾ࡅࡿ࣌ࣉࢳࢻ⤖ྜษ᩿ࡢẚ㍑㸦○Ᏻᒱ೺୕ࠊ⸨஭⣖Ꮚ㸧
7-1㸧❧య㓄ᗙゎᯒ㸸㹙┠ⓗ㹛⺮ⓑ㉁୰ࡢ Asp ࡟ࡣ㏻ᖖᆺࡢ Lα-Asp ௨እ࡟ Lβ-, Dα-, Dβ-Asp ␗ᛶయࡀᏑᅾࡍࡿࠋ⪁ேࡢ αA-Cry
ࡢ Asp-58 ࡜ αB-Cry ࡢ Asp-62 ࡣ㢧ⴭ࡟ Dβ ໬ࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀࠊఱᨾ Dβ-Asp ࡀ⵳✚ࡍࡿࡢ࠿ࡣ୙࡛᫂࠶ࡿࠋᮏ◊✲࡛ࡣࠊLα-, Dα-, Dβ-Asp58
ࢆ ྵ ࡴ αA-Cry ᶍ ᨃ ࣌ ࣉ ࢳ ࢻ 㸦 T6:
T55VfD58SGISEVR65 㸧୰ࡢ Asp58 ഃ㙐ࡢ❧య㓄ᗙtrans(T)ࠊgauche+(G+)ࠊgauche-(G-)ࡢẚ㍑ࢆ⾜ࡗࡓࠋ[᪉ἲ] Lα-, Dα-, Dβ-Asp58 ࢆྵࡴ T6 ࢆ PBS/D2O ࡟⁐ゎࡉࡏ 1H-NMR ᐃࢆ⾜࠸ Asp 58 Hβ ࢩࢢࢼࣝ࠿ࡽ
Hα-Hβ1 ࠾ࡼࡧ Hα-Hβ2 ࡢࢫࣆࣥࢫࣆࣥ࢝ࢵࣉࣜࣥࢢᐃ
ᩘ㸦Jαβ1, Jαβ12㸧ࢆᚓࡓࠋᚓࡽࢀࡓ Jαβ1, Jαβ12 ࢆ⏝࠸࡚ࠊ㸱✀ࡢ❧య㓄ᗙࡢᏑᅾ⋡ࢆ⟬ฟࡋࡓࠋ[⤖ᯝ࣭⪃ᐹ] T6 Lα ࡛ࡣ G+ࡀ᭱ࡶከࡃࠊT6 Dα ࡛ࡣ
G- ࡀ᭱ࡶඃ఩ࡔࡗࡓࠋ୍᪉ࠊT6 Dβ ࡛ࡣ T ࡀ 50%௨ୖࢆ༨ࡵ࡚࠸ࡓࠋ⤖ྜᆺ࢔࣑ࣀ㓟୰ࡢ Asp ࡢ␗ᛶ໬ࡣഃ㙐࢝ࣝ࣎ࣥ㓟Ⅳ⣲(CCOO-)࡟ C ഃ㞄᥋ṧᇶࡢ୺㙐ࡢ࢔࣑ࢻ❅⣲(N)ࡀᨷᧁࡋࠊ⎔≧ࡢࢫࢡࢩࣥ࢖࣑ࢻࢆ
ᙧᡂࡍࡿࡇ࡜࡟ࡼࡾ㐍⾜ࡍࡿࠋT ࡛ࡣ G+, G-ࡼࡾࡶ
&&22࡜ 1 ࡢ㊥㞳ࡀ㐲࠸ࡓࡵࠊࡇࡢ཯ᛂ࡟ࡣ୙฼࡛࠶
ࡾ␗ᛶ໬ࡋ࡟ࡃ࠸࡜⪃࠼ࡽࢀࡿࠋDβ-Asp ࡣ Tࡀከࡃࢫࢡࢩࣥ࢖࣑ࢻࢆᙧᡂࡋ࡟ࡃ࠸ࡓࡵ࡟Ᏻᐃ࡜࡞ࡾ
ᚎࠎ࡟⵳✚ࡍࡿࡶࡢ࡜⪃࠼ࡽࢀࡓ>@ࠋ
7-2㸧Asp ␗ᛶయ㛫࡟࠾ࡅࡿ࣌ࣉࢳࢻ⤖ྜษ᩿ࡢẚ㍑
⺮ⓑ㉁୰࡟⵳✚ࡋ࡚࠸ࡿ Dβ-Asp ࢆྵࡴ࣌ࣉࢳࢻ
ࡣ㏻ᖖࡢ Lα- Asp ࡜␗࡞ࡾ࣌ࣉࢳࢻ㙐ษ᩿ࡀ㉳ࡇࡾ࡟ࡃ࠸࡜ண᝿ࡉࢀࡿࠋࡋ࠿ࡋ࡞ࡀࡽࠊ࣌ࣉࢳࢻ⤖ྜษ᩿ࢆ Asp ␗ᛶయ㛫࡛ẚ㍑ࡋࡓሗ࿌ࡣ࡞࠸ࠋᮏ◊✲࡛ࡣࠊLαDβ-Asp ࢆྵࡴ  ✀ࡢ Cry ᩿∦࡟ࡘ࠸࡚ࠊ
ษ᩿㏿ᗘࢆࣜ࢔ࣝࢱ࢖࣒⁐ᾮ 105 ࡛ẚ㍑ࡋࡓࠋ[᪉ἲ]Lα-Dβ-Asp ࢆྵࡴ αA51-60(S51LFRTVLD58SG60)࡜ αB 61-67 (F61D62 TGLSG67)ࢆ
50 mM 㓑㓟ࣂࢵࣇ࢓࣮(pD4)୰࡛ 70 Υ࡛ࣜ࢔ࣝࢱ
࢖࣒⁐ᾮ NMR ᐃࢆ⾜ࡗࡓࠋαA51-60 ࡟ࡘ࠸࡚ࡣࠊ
Asp58 ࡢ C ഃ࡛ษ᩿ᚋ࡟⏕ࡌࡿ αA51-58 ࡢ C ᮎ➃
Asp58 Hα, N ᮎ➃ Ser59 Hβ, αB61-67 ࡟ࡘ࠸࡚ࡣࠊ
αB63-67 ࡢ N ᮎ➃ Thr63 ࡢ Hγ ࡢኚ໬ࢆᐃ㔞ࡋࡓࠋࡇࡢኚ໬ࢆ୍ḟ཯ᛂ࡜ࡋ࡚ᢅ࠸ࠊLα-, Dβ-Asp ࢆྵࡴ࣌ࣉࢳࢻࡑࢀࡒࢀ࡟ࡘ࠸࡚࣌ࣉࢳࢻ㙐ษ᩿㏿ᗘᐃᩘ kࢆỴᐃࡋࡓࠋ⾲  ࣌ࣉࢳࢻ㙐ษ᩿㏿ᗘᐃᩘ(k)Lα-AspDβ-AspαA51-60 6.9±0.5 2.2±0.4
αB61-67 4.7±0.9 1.3±0.2(×10-3 h-1)[⤖ᯝ࣭⪃ᐹ] ⾲ 2 ࡟♧ࡍࡼ࠺࡟ αA51-60ࠊαB61-67
ࡢ࡝ࡕࡽࡢ࣌ࣉࢳࢻ࡟࠾࠸࡚ࡶࠊDβ-Asp ࢆྵࡴ㓄ิ࡛࣌ࣉࢳࢻ⤖ྜࡢษ᩿ࡀ㉳ࡇࡾ࡟ࡃ࠸ࡇ࡜ࡀࠊึࡵ
࡚♧ࡉࢀࡓࠋࡇࡢ཯ᛂᛶࡢஈࡋࡉࡀ␗ᖖᆺ Dβ-Aspࡢ⵳✚ࡍࡿせᅉࡢ୍ࡘ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡓ[19]ࠋ
ཧ⪃ᩥ⊩[1] Kim I, Saito T, Fujii N, Kanamoto T, Chatake T and
Fujii N. Biochem.Biophys.Res.Commu.
466 ,622-628 (2015).
[2] Kim I, Saito T, Fujii N, Kanamoto T and Fujii N.
Amino Acids (2016) in press.
[3] Kinouchi et al. Biochem.Biophys.Res.Commu.
314, 730-736 (2004).
[4] Saito T and Fujii N. Radiat. Phys. Chem. 98, 57-63(2014).
[5] Sadakane Y, Konoha K, Kawahara M, Nakagomi K.
Chem. & Biodivers. 7, 1371-1379 (2010)[6] Sadakane Y, Fujii N, Nakagomi K. J Chromatogr. B.
879, 3240-3246 (2011)[7] Sadakane Y, Hatanaka Y. Anal. Biochem. 506, 1-7(2016)[8] Kawahara M, Mizuno, D, Koyama H, Konoha K,
Ohkawara S, Sadakane Y. Metallomics, 6, 209-219(2014)[9] Tamura H, Ohgami N, Fujii N. et al., PLoS ONE,(2012) 7(6), e39807[10] ATSDR (Agency for Toxic Substances and Disease
Registry). 2005.
[11] NTP (National Toxicology Program), (1994)
432,1-285.
[12] Takeuchi S. and Ando M., Am. J. Physiol. (1999)
277, 91-99.
[13] Ohgami N. et al., Proc. Natl. Acad. Sci. USA.,(2010) 107, 13051-13056.
[14] Ohgami N. et al., NeuroToxicology, (2012) 33,
1276-1283.
[15] Ohgami N et al., J. Expo. Sci. Environ. Epidemiol.,(2016) 26, 488-493[16] Fujii N. et al. J Biol Chem. 287, 39992-40002,(2012)[17] Maeda H. et al. Anal. Chem. 87, 561-568 (2015).
[18] Aki, K. & Okamura, E., Biophys. Chem. 196, 10-15(2015).
[19] Aki, K. & Okamura, E., Sci. Rep. 6, 21594; doi:
10.1038/srep21594 (2016)

Elucidation of generating mechanism of damaged protein induced by aging and irradiation
Noriko Fujii, Tadatoshi Kinouchi, Takeshi Saito, Takumi Takata,Yutaka Sadakane, Nobuhiro Ohgami, Norihiko Fujii, Kenzo Aki,
Ingu Kim and Takashi Kanamoto
nfujii@rri.kyoto-u.ac.jp㻙 䢸㻌㻙㻔㼀㻝㻕 ᐃㄝࢆ㉺࠼ࠊ᪂ࡓ࡞ࣉࣛࢫࢳࢵࢡࢩࣥࢳ࣮ࣞࢩࣙࣥ≀㉁࡟㛵ࡍࡿ◊✲࡜ࡑࡢᛂ⏝㸦ி኱ཎᏊ⅔㸧‫ۑ‬୰ᮧ⚽ோ⛉Ꮫࡢ㐍ᒎࡣࠊ᪂ࡋ࠸ᢏ⾡ࢆ๰⏕ࡋࡲࡍࠋ⚾ࡓࡕࡀຍ࠼࡚ࠊ⚾ࡓࡕࡣ⏕ᡂࡉࢀࡿග࡜ᒅᢡ⋡ࡢ஧ࡘࡢἼ

ྲྀࡾ⤌ࢇ࡛࠸ࡿ◊✲άືࠊගࡢἼ㛗ࢆኚ᥮ࡍࡿࣉࣛ
ࢫࢳࢵࢡ࡟㛵ࡍࡿ◊✲ࡣࠊࡲࡉ࡟ࡇࡢࡇ࡜ࢆయ⌧ࡋ࡚࠸ࡲࡍࠋࡇࡢ✀ࡢἼ㛗ኚ᥮ᮦࡣᑐ㇟࡜࡞ࡿගࡢἼ

㛗౫Ꮡᛶࢆᐃᘧ໬ࡍࡿࡇ࡜࡛᪂ࡓ࡞ගᏛࣃ࣓࣮ࣛࢱ
ࢆ⏕ࡳฟࡋࠊࢩࣥࢳ࣮ࣞࢩࣙࣥ≀㉁୰࡛ࡢගࡢఏᦙ
ࡢ⢭⦓໬ࢆᯝࡓࡋࡲࡋࡓ>@ࠋࡇࢀࡽࡢ⤖ᯝࢆ㋃ࡲ

㛗࡜ࡑࢀࢆཷගࡍࡿ ᐃᶵჾࡸ᳜≀➼ࡀ᳨▱ྍ⬟࡞Ἴ㛗࡜ࡢᕪࢆᇙࡵࡿࡓࡵࠊࣉࣛࢫࢳࢵࢡ࡟ᚤ㔞ࡢ⺯ග๣ࢆᩘ✀㢮ῧຍࡍࡿࡇ࡜࡛〇㐀ࡉࢀࡲࡋࡓࠋࡑࡢ

࠼ࠊ⺯ග๣ࢆῧຍࡏࡎ࡜ࡶ㧗⣧ᗘ໬࡟ࡼࡾࢩࣥࢳࣞ
࣮ࢩࣙࣥ≀㉁࡜ࡋ࡚ඃࢀࡓᶵ⬟ࢆⰾ㤶⎔࣏࣐࣮ࣜ࡟
௜୚࡛ࡁࡿࡇ࡜ࢆ♧ࡋࡓ௚ࠊᕤᴗⓗ࡟฼⏝ࡢᐜ᫆࡞ᰂ㌾࡞ຍᕤᛶ࡜ඃࢀࡓྍረᛶࡣࠊගఏᦙ⏝ࣇ࢓࢖ࣂ࣮࠿ࡽస≀᱂ᇵ⏝ࣇ࢕࣒ࣝ࡟ཬࡪᖜᗈ࠸ᛂ⏝ࢆᐇ⌧ࡋ࡚࠸ࡲࡍࠋ

ⰾ㤶⎔࣏࣐࣮ࣜ㸦࣏࢚ࣜࢳࣞࣥࢸࣞࣇࢱ࣮ࣞࢺࠊ࣏
࢚ࣜࢳࣞࣥࢼࣇࢱ࣮ࣞࢺ࡞࡝㸧ࢆከᩘ᫂ࡽ࠿࡟ࡋࠊ
ࡑࢀࡽⰾ㤶⎔࣏࣐࣮ࣜࡢࣈࣞࣥࢻ࡟ࡼࡾගᏛ≉ᛶࢆㄪᩚྍ⬟࡛࠶ࡿࡇ࡜ࢆᐇドࡋࡲࡋࡓ>@ࠋࡑࢀࡽࡢ୰࡛ⰾ㤶⎔࣏࣐࣮ࣜࢆ࣮࣋ࢫᮦ࡜ࡋࡓἼ㛗ኚ᥮ᮦࡣࢩࣥࢳ࣮ࣞࢩࣙࣥ≀㉁࡜ࡋ࡚㛤ⰼࡋࠊཎᏊ
ຊ࣭ᨺᑕ⥺ࢆྲྀࡾᢅ࠺᪋タࡸ་⒪ᶵ㛵࡛ࡢᏳ඲⟶⌮࡟࠾࠸࡚ᚲせ୙ྍḞ࡞ᨺᑕ⥺ィ ⣲ᮦࡢ୍ࡘ࡟࡞ࡾ
ࡲࡋࡓࠋࡑࡢṔྐࡣ⣙୍ୡ⣖࡟ཬࡧࡲࡍࡀࠊࡑࡢἼ
㛗ኚ᥮ᶵᗎࡣⰾ㤶⎔࣏࣐࣮ࣜ࡟⏕ᡂࡉࢀࡓගࢆ⺯ග๣࡛྾཰࣭෌Ⓨගࡍࡿࡇ࡜࡛ẁ㝵ⓗ࡟㛗Ἴ㛗࡬ኚ᥮ࡍࡿࡶࡢ࡜ࡋ࡚ᐃ╔ࡋ࡚ࡁࡲࡋࡓࠋࡋ࠿ࡋࠊ⚾ࡓࡕࡣࠊἼ㛗ኚ᥮ᶵᗎ࡟ᚑ᮶࡟↓࠸ゎ㔘ࢆ୚࠼ࡿࡇ࡜࡛
ఏ⤫ⓗ࡞▱㆑ࢆࣈࣞ࢖ࢡࡋࡲࡋࡓࠋ
ᐃㄝ࡟ᇶ࡙ࡅࡤࠊኚ᥮ᑐ㇟࡜࡞ࡿ⺯ගࡢศᕸ࡜㔜࡞ࡿ྾཰ࢫ࣌ࢡࢺࣝࢆ᭷ࡍࡿ⺯ග๣ࡢῧຍࡀᚲせ୙ྍḞ࡜࡞ࡾࡲࡍࠋࡑࡢཝࡋ࠸ไ⣙࡟ࠊ⚾ࡓࡕࡣ╔║ࡋࡲࡋࡓࠋኚ᥮ᑐ㇟ࡢ⺯ගศᕸ࡜㔜࡞ࡽ࡞࠸྾཰ࢫ࣌
ࢡࢺࣝࢆ᭷ࡍࡿ⺯ග๣ࢆᩒ࠼࡚ⰾ㤶⎔࣏࣐࣮ࣜ࡟ῧ
ຍࡋࠊࡑࡢ⺯ග๣ࡢศᏊ㛫㊥㞳ࢆᗈ⠊ᅖ࡛ไᚚࡍࡿࠊ
࡜࠸࠺᩾᪂࡞ᡭἲࢆ⦅ࡳฟࡋ࡚ගࡢᛂ⟅ࢆㄪ࡭ࡲࡋ
ࡓࠋࡑࡢ⤖ᯝࠊⰾ㤶⎔࣏࣐࣮ࣜ࡜⺯ග๣㛫࡟᪂ࡓ࡞㟁Ꮚ≧ែࡀᙧᡂࡉࢀࠊࡑࡢ㑄⛣ࢆ௓ࡋ࡚ගࡢἼ㛗ࡀኚ᥮ࡉࢀࡿࠊ࡜࠸࠺᪂ࡋ࠸ᶵᗎࡢᏑᅾࢆ᫂࠿ࡋࡲࡋ
ࡓ>@ࠋ࢖ࣀ࣮࣋ࢩࣙࣥࡣࠊ⛉Ꮫ࡜ᢏ⾡ࡢዲᚠ⎔ࡢ⇿Ⓨ࡛ࡍࠋ㛗࠸㛫ࠊἼ㛗ኚ᥮ࡣ⺯ග๣ࡢࢩࣥࣉࣝ࡞ᶵ⬟࡟ࡼࡿࡶࡢ࡛࠶ࡾࠊᨵⰋࡢవᆅࡣぢฟࡉࢀࡎࠊ᪂⣲ᮦࡢ㛤
Ⓨࡸᛂ⏝࡟࠾ࡅࡿ㌍㐍ࡣ೵⁫ࡋࡀࡕ࡛ࡋࡓࠋࡋ࠿ࡋࠊ
ࡇࡢἼ㛗ኚ᥮ᶵᗎࡢ῝໬࡟ࡼࡾⰾ㤶⎔࣏࣐࣮ࣜ࡟ῧ
ຍ࡛ࡁࡿ⺯ග๣ࡢ㑅ᢥ⫥ࡣᣑ኱ࡋࠊ┠ⓗ࡟ᛂࡌࡓἼ
㛗࡬ኚ᥮࡛ࡁࡿ⣲ᮦࡢタィཬࡧ㛤Ⓨ࡬ࡢ㐨ࡀᣅ࠿ࢀࡲࡋࡓࠋ෗┿㸸඾ᆺⓗ࡞࣮࣋ࢫᮦ࡛࠶ࡿ࣏ࣜࢫࢳࣞࣥ࡟࣋ࣥ
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࡛ࡣ ࠊከ┠ⓗ ࢩࣥࢡࣟ ࢺ࣭ࣟࣥ ࢱࣥࢹ࣒ ຍ㏿ ჾ
㸦W-MAST㸧ࡢ㧗࢚ࢿࣝࢠ࣮㝧Ꮚ⥺ࢆ౑⏝ࡋࡓࡀࢇ἞⒪⮫ᗋ◊✲ࢆᖹᡂ 14 ᖺᗘ࠿ࡽᖹᡂ 21 ᖺᗘࡲ࡛ᐇ
᪋ࡋࡓ[1]ࠋ➹⪅ࡣࡑࡢ᭱⤊ᖺᗘ࡟㉱௵ࡋࠊࢃࡎ࠿ 1ᖺ㛫࡛ࡣ࠶ࡗࡓࡀ་Ꮫ≀⌮ኈ࡜ࡋ࡚⮫ᗋᴗົ࡟ᦠࢃ
ࡗࡓࠋ་Ꮫ≀⌮ᴗົࢆಶࠎࡢᝈ⪅࡟㛵ࢃࡿᴗົ࡜⿦
⨨࡟㛵ࢃࡿᴗົ࡟ศࡅ࡚⤂௓ࡍࡿࠋಶࠎࡢᝈ⪅࡟㛵ࢃࡿ୍㐃ࡢᴗົ࡜ࡋ࡚ࠊࡲࡎࠊデ⒪ᨺᑕ⥺ᢏᖌ࡟ࡼࡾ᧜ᙳࡉࢀࠊ་ᖌ࡟ࡼࡾᶆⓗ㡿ᇦ㸦PTV㸧࡜ࣜࢫࢡ⮚ჾ㸦OAR㸧ࡢ㍯㒌ࡀ᭩ࡁ㎸ࡲࢀࡓ CT ⏬ീࢆࡶ࡜࡟ࠊ἞⒪ィ⏬⿦⨨ࢆ⏝࠸࡚⥺㔞ศᕸィ⟬࡜ PTV࣭OAR ࡢ⥺㔞ホ౯ࢆ⾜࠺ࠋ⥆࠸࡚ࠊ་ᖌࡢᢎㄆࢆᚓࡓ἞⒪ィ⏬࡟ᇶ࡙ࡁࠊ↷ᑕ㔝ࢆᙧᡂࡍࡿࡓࡵࡢ࣮࣎ࣛࢫ࣭ࢥ࣓࣮ࣜࢱࢆస〇ࡍࡿࠋࡇࢀࡽࡢస〇࡟ࡣࠊ࣐ࢩࢽࣥࢢࢭࣥࢱ࡜࣡࢖ࣖᨺ㟁ຍᕤᶵࢆ౑⏝ࡋࡓࠋ᭱⤊ⓗ࡟ࠊỈࣇ࢓ࣥࢺ࣒୰࡛ࡢ⥺㔞ศᕸ ᐃ࡟ࡼࡾ἞⒪ィ⏬࠾ࡼࡧస〇ࡋࡓ࣮࣎ࣛࢫ࣭ࢥ
࣓࣮ࣜࢱᙧ≧ࡢ᳨ド㸦ᝈ⪅ QA㸧ࢆ⾜࠺ࠋࡉࡽ࡟ࠊᢞ
୚⥺㔞࡜ࣔࢽࢱ㟁㞳⟽ィ ್㸦MU ್㸧ࡢ್௜ࡅ㸦᪂ᝈ ᐃ㸧ࢆ⾜࠸ࠊ↷ᑕ࡟⮫ࡴࠋࢫࢱࢵࣇࡀᑡᩘ࡛࠶
ࡗࡓࡇ࡜ࡶ࠶ࡾࠊ᪥ࠎࡢ↷ᑕ࡟࠾࠸࡚ࠊᝈ⪅ẖࡢ࣮࣎ࣛࢫ࣭ࢥ࣓࣮ࣜࢱタ⨨࣭஺᥮ࡸྛ✀↷ᑕᶵჾࡢ᮲
௳タᐃࠊMU ್ࡢධຊ࡜࠸ࡗࡓసᴗࡶ་Ꮫ≀⌮ኈࡢᴗົ࡛࠶ࡗࡓࠋ
⿦⨨࡟㛵ࢃࡿᴗົ࡜ࡋ࡚ࠊ἞⒪ィ⏬ࡢ⥺㔞ィ⟬࡟ᚲせ࡜ࡉࢀࡿ CT ್㸫Ỉ➼౯ཌኚ᥮ಀᩘࡢ ᐃࠊ↷ᑕሙ≉ᛶࡢᐃᮇ ᐃࠊࣜࣇ࢓ࣞࣥࢫ⥺㔞ィࡢᰯṇࠊጞᴗ๓ࡢࣔࢽࢱ㟁㞳⟽ᰯṇ➼ࠊ୺࡟↷ᑕᶵჾ࡟㛵ࢃ
ࡿ QA ࣉࣟࢢ࣒ࣛࡢᐇ⾜࡜ಖᏲ⟶⌮ࢆ⾜ࡗࡓࠋࡉࡽ
࡟ࠊ࣮࣎ࣛࢫ࣭ࢥ࣓࣮ࣜࢱຍᕤᶵࡸࠊ἞⒪ィ⏬⿦⨨ࠊࢹ࣮ࢱ࣮࣋ࢫࢧ࣮ࣂࠊࢿࢵࢺ࣮࣡ࢡ⎔ቃ➼ࡢ㛵㐃ᶵჾࡢಖᏲ⟶⌮ࡶ἞⒪ࢆ෇⁥࡟㐍ࡵࡿୖ࡛㔜せ࡞ᴗົ࡛࠶ࡗࡓࠋ㸱㸬↷ᑕᐇ㦂ࡢࡓࡵࡢࣅ࣮࣒฼⏝⎔ቃ㛤Ⓨ㸸W-MAST࡟ࡣࠊࢱࣥࢹ࣒ຍ㏿ჾࡢࡳࢆ౑⏝ࡋࡓప࢚ࢿࣝࢠ࣮
ࣅ࣮࣒฼⏝⣔࡜ࢩࣥࢡࣟࢺࣟࣥࢆ౑⏝ࡋࡓ㧗࢚ࢿࣝࢠ࣮ࣅ࣮࣒฼⏝⣔ࡀ࠶ࡾࠊ➹⪅ࡢᡤᒓࢢ࣮ࣝࣉࡣ㧗࢚ࢿࣝࢠ࣮ࣅ࣮࣒฼⏝⣔ࡢᐇ㦂ᨭ᥼࡜ಖᏲ⟶⌮ࢆᢸᙜࡋࡓࠋ㧗࢚ࢿࣝࢠ࣮ࣅ࣮࣒฼⏝⣔ࡣ㝧Ꮚ⥺἞⒪ࣅ
࣮࣒ࣛ࢖ࣥ࡜⏕≀↷ᑕ⏝ࣅ࣮࣒ࣛ࢖ࣥ࠿ࡽᵓᡂࡉࢀࠊ
๓⪅ࡣࡀࢇ἞⒪㛵㐃◊✲ࠊᚋ⪅ࡣ࢖࢜ࣥࣅ࣮࣒⫱✀ࡸᮦᩱ↷ᑕࠊ⾨ᫍᦚ㍕ᶵჾ➼ࡢᏱᐂ㛵㐃◊✲࡟฼⏝ࡉࢀࠊ㠀ᖖ࡟ከᙬ࡞◊✲ࡢሙ࡛࠶ࡗࡓ[1]ࠋ
➹⪅ࡽࡣᡤෆእ࣮ࣘࢨ࣮ࡢᐇ㦂࡟࠾࠸࡚ࠊ↷ᑕሙࡢᙧᡂ࡜ ᐃホ౯ࢆᢸᙜࡋࡓࠋ⏕≀ࢆᑐ㇟࡜ࡋࡓᐇ㦂࡛ࡣࠊホ౯ࡍ࡭ࡁ≀⌮㔞ࡣ㝧Ꮚ⥺἞⒪࡜ྠࡌࡃỈ྾཰⥺㔞࡛࠶ࡾࠊᐜ᫆࡟ ᐃࡀྍ⬟࡛࠶ࡗࡓࠋ ᐃࡀᐜ᫆࡞୍᪉࡛ࠊ⥲⥺㔞ࡢ኱ᑠࡸ⥺㔞ศᕸᆒ୍ᛶ➼ࠊ࣮ࣘࢨ࣮ẖࡢ↷ᑕ᮲௳࡟ྜࢃࡏࡓ↷ᑕ㔝ࡢ᳨ウ࣭ホ౯ࡀᚲせ࡜ࡉࢀࡓࠋ౛࠼ࡤࠊ⪏ᨺᑕ⥺ᛶࡢ㧗࠸⳦㢮ࡸ✀Ꮚ࡟ᑐࡋ࡚ 1000 Gy ௨ୖࡢ↷ᑕࢆ⾜࠺ࡇ࡜ࡶ࠶
ࡾࠊศᕸࡢᆒ୍ᛶࡀࡸࡸᝏࡃ࡞ࡿࡀࠊࣅ࣮࣒ࢆ⤠ࡿࡇ࡜࡛↷ᑕ᫬㛫ࡢ▷⦰ࢆᅗࡗࡓࠋࡲࡓࠊ⣽⬊⏕Ꮡ⋡➼ࡢᐇ㦂࡛ࡣࠊ↷ᑕ㔝ᙧᡂ᮲௳ࢆ᥈⣴ࡋࠊᆒ୍ᛶྥ
ୖ࡟ὀຊࡋࡓࠋ
୍᪉ࠊᮦᩱࡸ༙ᑟయ⣲Ꮚࠊ᳨ฟჾ➼ࢆᑐ㇟࡜ࡋࡓ
ᐇ㦂࡛ࡣࠊホ౯ࡍ࡭ࡁ≀⌮㔞ࡣ⢏Ꮚࣇࣛࢵࢡࢫ࡛࠶
ࡾࠊ㝈ࡽࢀࡓィ ᶵჾࢆ౑⏝ࡋ࡚ᕤኵࡋ࡞ࡀࡽ ᐃࡍࡿᚲせࡀ࠶ࡗࡓࠋᚲせ࡜ࡉࢀࡿࣇࣛࢵࢡࢫࡢ᮲௳
ࡣᐇ㦂ẖ࡟኱ࡁࡃ␗࡞ࡾࠊ᭷㝈㠃✚ࡢࣉࣛࢫࢳࢵࢡ
ࢩࣥࢳ࣮ࣞࢱ➼࡛ィᩘ࡛ࡁࡿሙྜࡣẚ㍑ⓗ ᐃࡀᐜ᫆ࡔࡀࠊ㧗ࣇࣛࢵࢡࢫࡢሙྜ࡟ࡣࣅ࣮࣒㟁ὶィ ࡜࢖࣓࣮ࢪࣥࢢࣉ࣮ࣞࢺ➼ࡢ㠃᳨ฟჾࢆ⤌ࡳྜࢃࡏ࡚
ᐃࢆᐇ᪋ࡋࡓࠋ᳨ฟჾ࡟㛵ࡍࡿᐇ㦂࡛ࡣ࣮ࣘࢨ࣮ࡢせᮃࡶከᵝ࡛࠶ࡾࠊ౛࠼ࡤࣅ࣮࣒ࢲࣥࣉࡢᮦ㉁ࢆ
ኚ᭦ࡍࡿࡇ࡜࡛୰ᛶᏊࡢⓎ⏕ࢆᢚ࠼ࣂࢵࢡࢢࣛ࢘ࣥ
ࢻィᩘ⋡ࢆపῶࡋࡓࡾࠊᴟపィᩘ⋡ᐇ㦂ࡢࡓࡵ࡟ᩓ
஘⥺ࢆ౑⏝࡟౪ࡋࡓࡾ࡜ࠊ࣮ࣘࢨ࣮࡜༠㆟ࡋ࡞ࡀࡽᐇ㦂ሙࢆᥦ౪ࡋ࡚ࡁࡓࠋ
㸲㸬⤖ㄒ㸸⌧ᅾࡢ➹⪅ࡢ≧ἣࡣ WERC ᡤᒓ᫬࡜Ⰻࡃ
ఝ࡚࠸ࡿࠋ㝧Ꮚ⥺἞⒪ࡀ୍⯡໬ࡋጞࡵࠊ௚᪋タࡢࡼࡾὙ⦎ࡉࢀࡓ⿦⨨ࡸᢏ⾡࡟่⃭ࢆཷࡅࠊࡑࢀࢆព㆑
ࡋࡘࡘ᪥ࠎࡢᴗົࡸ◊✲࡟ྥ࠿ࡗ࡚࠸ࡓࠋ⌧ᅾࡢ࣍࢘⣲୰ᛶᏊᤕᤊ⒪ἲ㸦BNCT㸧ࡶ඲ࡃྠࡌ≧ἣ࡟࠶ࡿࠋ
⮫ᗋᴗົࡸ⮬㌟ࡢ◊✲ࡢࡳ࡞ࡽࡎࠊWERC ࡜ྠᵝ࡟࣮ࣘࢨ࣮࡟ᐇ㦂ሙࢆᥦ౪ࡍࡿࡇ࡜ࡶඹྠ฼⏝᪋タࡢ୍ဨ ࡜ࡋ࡚㔜 せ࡞௵ົ ࡛࠶ࡿ࡜ ㄆ㆑ࡋ࡚ ࠸ࡿ ࠋ
WERC ࡛ࡢ⤒㦂ࢆᏑศ࡟ά࠿ࡋ࡚ࠊཎᏊ⅔ᐇ㦂ᡤࡢ࢔ࢡࢸ࢕ࣅࢸ࢕࣮࡟㈉⊩ࡍࡿᡤᏑ࡛࠶ࡿࠋཧ⪃ᩥ⊩[1] Annual Report of the Wakasa Wan Energy ResearchCenter, Vol. 12 (2009), Vol. 16 (2013).

Arrangement of Irradiation Field for Accelerated Ion Beam with Tens to Hundreds of MeV – from Medical/Bio Science to SpaceTechnology ±Takushi Takata
taku-takata@rri.kyoto-u.ac.jp㻙 㻤㻌㻙㻔㼀㻞㻕 ᪥ᮏ࡜࣋ࢺࢼ࣒࡟࠾ࡅࡿ⎔ቃၥ㢟ࡢゎỴࢆࡵࡊࡍᢏ⾡㛤Ⓨ̿ᨺᑕᛶࢭࢩ࣒࢘࡜◉⣲ࡢ㝖ཤ㸦ி኱ཎᏊ⅔㸧‫⸨ۑ‬ᕝ㝧Ꮚ㸯㸬ᵝࠎ࡞ᗫᲠ≀ࡢᇙ❧࡚࡜ᆅୗỈၥ㢟㸸᰾࢚ࢿࣝࢠ࣮ࡸᨺᑕ⥺฼⏝࡟࡜ࡶ࡞࠸Ⓨ⏕ࡋࡓᨺᑕᛶᗫᲠ≀ࡣ᭱⤊ⓗ࡟ࡣᆅ୰ᇙタฎศ࡟௜ࡉࢀࡿࡇ࡜࡟࡞ࡿࠋ
౛࠼ࡤⓎ㟁ᡤᗫᲠ≀ࡣ㸪ᨺᑕ⬟ࣞ࣋ࣝࡸⓎ⇕ࡢ⛬ᗘ࡟ᛂࡌ␗࡞ࡿ῝ࡉࡢᆅ୰࡟ᇙタࡉࢀࡿ㸦ᆅᒙฎศ㸸300㹫௨῝ࠊవ⿱῝ᗘฎศ㸸῝ᗘ 50m㹼100mࠊὸᆅࠋᇙ❧࡚ฎศ ࡢᏳ඲ホ౯ࡣࠊ୰ฎศ㸸῝ᗘᩘ m⛬ᗘ㸧ձᆅୗ࡟ᇙタࡉࢀࡓᗫᲠయ࠿ࡽᆅୗỈὶࢀሙ࡬ࡢᨺᑕ
ᛶ᰾✀ࡢ⁐ฟࠊղᆅୗỈὶື࡞ࡽࡧ࡟ᆅୗỈ㸫ᆅ㉁፹
య⣔࡟࠾ࡅࡿᨺᑕᛶ᰾✀ࡢᅛᾮศ㓄࡜⛣⾜≉ᛶࢆ⪃៖ࡋࡓ᰾✀⛣⾜㐣⛬ࠊճᆅୗỈ୰ࡢᨺᑕᛶ᰾✀ࡀ⏕ែᅪ࡟ᾐ₶ࡋᵝࠎ࡞⎔ቃ୰ࡢせ⣲㛫ࢆ⛣⾜ࡋ࡚᭱⤊ⓗ࡟ே࡬ࡢ⿕ࡤࡃࢆ୚࠼ࡿㅖ㐣⛬ࠊࢆࡑࢀࡒࢀண ホ౯ࡍࡿࡇ࡜࡛ᐇ᪋ࡍࡿࠋ➹⪅ࡣ≉࡟ᆅᒙฎศ࡟௜ࡉࢀࡿ㧗ࣞ࣋ࣝᨺᑕᛶᗫᲠ≀ࡢฎศࡢᏳ඲ホ౯࡟࠿࠿ࢃࡾࠊղࡢ
㐣⛬ࡢ◊✲ࢆ⾜ࡗ࡚ࡁࡓࠋ
ࡉ࡚ࠊ㠀ᨺᑕᛶࡢ୍⯡࠾ࡼࡧ⏘ᴗᗫᲠ≀ࡣࠊ᪥ᮏ࡛
ࡣ୺࡟↝༷࡟ࡼࡿῶᐜࢆ⤒࡚ᇙࡵ❧࡚ฎศࡉࢀࡿࠋ୍
㒊ࡢ᭷ᶵ⣔ᅛయᗫᲠ≀࡟ࡘ࠸࡚ࡣ᎘Ẽᾘ໬࡟ࡼࡿῶᐜ
ࢆ⤒ࡿࡀࠊ௒ࡢ᪥ᮏ࡛ࡣࠊ᭷ᶵ⣔ࡢᗫᲠ≀ࢆࡑࡢࡲࡲ
ᇙࡵ❧࡚ࡿࡇ࡜ࡣᑡ࡞ࡃ࡞ࡾࠊᇙ❧ᗫᲠ≀ࡢ↓ᶵ໬ࡀ㐍ࢇ࡛࠸ࡿࠋ࡜ࡶ࠶ࢀࠊᇙ❧ᆅᾐฟỈ࡟ࡣᗫᲠ≀࡟⏤᮶ࡍࡿ࡞࡟ࡀࡋ࠿ࡢở⃮≀㉁ࡀྵࡲࢀࡿࡇ࡜࡟࡞ࡿࠋ㛵すࡢ኱㜰‴ᗈᇦ⮫ᾏᩚഛ஦ᴗ㸦ࣇ࢙ࢽࢵࢡࢫ㸧ࡸᮾிࡢክࡢᓥ➼ࡢࡼ࠺࡞ᾏ㠃ᇙࡵ❧࡚ࡢሙྜࠊᾐฟỈࡣฎ⌮ᚋࠊᾏᇦ࡟ᨺὶࡉࢀࡿࡀࠊ㹆25ᖺᗘ᫬Ⅼࡢ⤫ィ࡛ࡣࠊࡈࡳࡢ᭱⤊ฎศሙࡢ඲యᐜ㔞ࡢ⣙70%ࡣෆ㝣ᖹᆅ࣭ᒣ㛫ࡢฎศሙࡀ༨ࡵ࡚࠸ࡿ
[1]ࠋᨺᑕᛶᗫᲠ≀ࡢᇙタฎศࡢሙྜ࡜ྠᵝ࡟ࠊᇙ❧࡚ࡽࢀࡓ୍⯡y⏘ᴗᗫᲠ≀࠿ࡽࡢᾐฟ≀ࡀᆅୗỈࢆởᰁࡍࡿྍ⬟ᛶࡀ࠶ࡾࠊࢃࡀᅜ࡛ࡢ஦౛ሗ࿌ࡶ࠶ࡿ
㸦౛࠼ࡤ[2]㸧
ࠋࡋ࠿ࡋࠊᆅୗ⎔ቃࡢ୙ྍどᛶࡢ㧗ࡉࡺ࠼࡟ᗫᲠ≀ฎศሙ⏤᮶ࡢᆅୗỈởᰁ࡟ࡘ࠸࡚ࡢㄪᰝ஦
౛ࡑࡢࡶࡢࡀᑡ࡞࠸ࡢࡀ⌧≧࡛࠶ࡾࠊᗫᲠ≀ᇙ❧ฎศሙ⏤᮶ࡢᆅୗỈởᰁࡼࡾࠊ࠸ࢃࡺࡿ᤼Ỉࡢᆅୗᾐ㏱࡟
ࡼࡿᆅୗỈởᰁࡢ࡯࠺ࡀከ࠸࡜࠸࠺ሗ࿌ࡶᏑ
ᅾࡍࡿ[3]ࠋ࡜ࡣ࠸࠼ࠊ୍⯡y⏘ᴗᗫᲠ≀ᇙ❧ฎศሙࡢ᪂つ❧ᆅࢆᅗࢁ࠺࡜ࡍࡿ࡜ࠊᚲࡎᇙࡵ❧࡚ᆅ࠿ࡽࡢᨺ
ὶỈ࡟ࡼࡿ⎔ቃởᰁࡢྍ⬟ᛶࡀၥ㢟࡟࡞ࡾࠊෆ㝣y ᒣ㛫ᆺฎศሙࡢሙྜࡣࠊᆅୗỈࡢၥ㢟ࡀ኱ࡁ࡞ẚ㔜ࢆ༨ࡵࡿࡇ࡜࡟࡞ࡿࠋ
ࡇࡢࡼ࠺࡟ࠊᆅୗỈởᰁࡇࡑࡣᨺᑕᛶy㠀ᨺᑕᛶࢆၥ
ࢃࡎᗫᲠ≀ࡢ᭱⤊ฎศࢆ㐍ࡵࡿୖ࡛ホ౯ࡢ࣏࢖ࣥࢺ࡜
࡞ࡿ⎔ቃせ⣲࡛࠶ࡿࠋ⚟ᓥ➨୍ཎⓎ஦ᨾ࡜ᣦᐃᗫᲠ≀ၥ㢟ࠊⴭ⪅ࡽࡢྲྀࡾ⤌ࡳ㸸⚟ᓥ➨୍ཎⓎ(1F)஦ᨾࡢᚋ、ᨺᑕᛶࢭࢩ࣒࢘
ࡢ⎔ቃởᰁࡀ᪂ࡓ࡞ၥ㢟࡜ࡋ࡚ᾋୖࡋࡓࠋ㣗ရ࣭᪥⏝ရ࡟ࡘ࠸࡚ࡣᚭᗏࡋࡓᨺᑕ⬟ࡢࢫࢡ࣮ࣜࢽࣥࢢ࡟ࡼࡾ
࠿࡞ࡾᅜẸࡢ୙Ᏻࡢపῶࡀࡣ࠿ࡽࢀ࡚ࡁࡓࠋ1F㻙 㻥㻌㻙஦ᨾࡢᙳ㡪ࢆཷࡅࡓᆅᇦࡢୖୗỈ㐨ฎ⌮ởἾࡸ↝༷⅊➼ࡢᗫᲠ≀୰࡟ࡣ஦ᨾᚋ 5 ᖺࡀࡓࡗ࡚ࡶࠊᨺᑕᛶ
ࢭࢩ࣒࢘ࡀ᳨ฟࡉࢀ⥆ࡅ࡚࠸ࡿࠋࡇࢀࡽᗫᲠ≀ࡣ
Cs-134+Cs-137 ⃰ᗘࡀ 8,000 Bq/kg ࢆ㉸࠼ࡿ࡜ᨺᑕᛶ
≀㉁ởᰁᑐฎ≉ᥐἲ࡟࠿࠿ࢃࡿᣦᐃᗫᲠ≀y≉ᐃᗫᲠ≀࡜࠸࠺ᢅ࠸࡟࡞ࡿࠋᣦᐃᗫᲠ≀ࡣࠊ௒ᚋࠊᣦᐃ
ᗫᲠ≀ฎศሙ࡟ᇙࡵ❧࡚ࠊᣦᐃᗫᲠ≀ࡢ࠺ࡕᨺᑕᛶ
ࢭࢩ࣒࢘⃰ᗘ 10 ୓ Bq/kg ࢆ㉸࠼ࡿࡶࡢࡣ୰㛫㈓ⶶ᪋
タ࡛ಖ⟶ᚋࠊ⚟ᓥ┴እ࡛᭱⤊ฎศࡉࢀࡿࡇ࡜࡟࡞ࡗ
࡚࠸ࡿࠋ୍᪉ࠊCs-134+Cs-137 ࡟ࡘ࠸࡚ 8,000 Bq/kg௨ୗ࡛࠶ࢀࡤࠊ㏻ᖖࡢ㠀ởᰁᗫᲠ≀࡜ྠᵝ࡟⟶⌮ᆺฎศሙ࡬ࡢᇙࡵ❧࡚ྍ⬟࡜ࡉࢀ࡚࠸ࡿࠋࡋ࠿ࡋ࡞ࡀ
ࡽࠊ⚟ᓥ┴௨እࡢྛᆅ࡛ࡣࠊ1F ஦ᨾ⏤᮶ࡢᨺᑕᛶࢭ
ࢩ࣒࢘ࢆྵࡴྛ✀ࡢᗫᲠ≀ࡣࠊᣦᐃᗫᲠ≀ࡢ⠊␪࡟ධࡽ࡞࠸ᨺᑕᛶࢭࢩ࣒࢘⃰ᗘࡢప࠸ᗫᲠ≀࡛ࡶࠊฎศሙ࡟ᦙධ࡛ࡁࡎࠊฎ⌮᪋タ࡟࡚ಖ⟶ࡉࢀ࡚࠾ࡾࠊ
ࡲࡓᕷẸࡢ཯ᑐ࡟ࡼࡾᣦᐃᗫᲠ≀ฎศሙ❧ᆅࡢࡵ࡝ࡣ❧ࡗ࡚࠸࡞࠸ࠋ⚟ᓥ┴࡛ࡣᣦᐃᗫᲠ≀ฎศሙࡢࢧ
࢖ࢺࡣỴࡲࡗࡓࡶࡢࡢࠊᆅඖ࡜ࡢྜពࡣࠊ᏶඲࡟ᡂ
❧ࡋ࡚࠾ࡽࡎࠊฎศሙ࡬ࡢᗫᲠ≀ᦙධ᫬ᮇࡣᮍᐃ࡛
࠶ࡿࠋࡇࡢࡼ࠺࡞୰ࠊ➹⪅ࡽࡣᗫᲠ≀↝༷⅊ࢆᡭጞࡵ࡟ࠊ
㛵ᮾ௨໭ࡢୗỈฎ⌮ሙ࡟࠾࠸࡚ࠊୗỈởἾ↝༷⅊ཬࡧ⁐⼥㣕⅊➼ࢆᑐ㇟࡟ࡋ࡚ ࢩࣗ࢘㓟࠾ࡼࡧỈ࡟ࡼࡿᢳฟ࡜ࣇ࢙ࣟࢩ࢔ࣥ໬≀ඹỿἲ࡟ࡼࡿࢭࢩ࣒࢘ࡢ
ศ㞳⃰⦰࣭จ㞟ỿẊ࡟ࡼࡾ, ᣦᐃᗫᲠ≀ࢆ኱ᖜ࡟ῶ
ᐜࡍࡿ◊✲ࢆᖹᡂ 25 ᖺᗘ௨᮶⾜ࡗ࡚ࡁࡓࠋ࡞࠾ࠊᣦ
ᐃᗫᲠ≀ࡣⓎ⏕ᆅ࠿ࡽࡢ⛣ືࡀཎ๎⚗Ṇࡉࢀ࡚࠸ࡿࠋ
ࡑࡢࡓࡵ➹⪅ࡽࡣᣦᐃᗫᲠ≀Ⓨ⏕ᆅࡢฎ⌮ሙෆ࡛ᗫᲠ≀ヨᩱࡢᥦ౪ࢆཷࡅࠊฎ⌮ሙෆ࡟኱Ꮫࡀᚲせᶵᮦࢆᣢࡕ㎸ࢇ࡛ヨ㦂ࢆ⾜࠺⌧ሙヨ㦂᪉ᘧ࡛◊✲ࢆ⾜ࡗ࡚ࡁࡓ㸦ᅗ㸯㸧ࠋ䝅䝳䜴㓟䝰䝞䜲䝹䝷䝪䝷䝖䝸ᢳฟ䛻䜘䜛⌧ሙヨ㦂䠄4䠉5᪥㛫䠅㔜㔠ᒓ➼ศᯒ
䠄voltammetry+A/S䠅ᣦᐃᗫᲠ≀ヨᩱཷ㡿䠄┬ᗇ䞉⮬἞యㄆྍᚋ䠅⌧ሙ䛷ヨᩱᑠศ䛡ྍᦙᆺ䝀䝹䝬䛻䜘䜛᰾✀ศᯒ䛷㝖ᰁ⋡ ᐃỈᢳฟ䝣䜵䝻䝅䜰䞁໬≀ඹỿἲ䜢ᢳฟᾮ䛻㐺⏝㐲ᚰศ㞳䛷ᅛᾮศ㞳ඹỿ≀

Fig. 1 Procedures of on-site test treating designated waste samples containing radioactive
cesium㠀࢖࢜ࣥ≧࡛Ꮡᅾࡋ࡚࠸ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡓࠋࡑࡇ
࡛ྠᢳฟᾮ࡟ࡘ࠸࡚ࢡࣟࢫࣇ࣮ࣟ᪉ᘧࡢ㝈እࢁ㐣ヨ㦂ࢆ⾜ࡗࡓ⤖ᯝࠊศᏊ㔞 5,000 ๓ᚋࡢ⪏ⅆᛶࡢඖ⣲➼࠿ࡽᡂࡿࢥࣟ࢖ࢻ≧≀㉁ࡀᏑᅾࡍࡿྍ⬟ᛶࡢ࠶ࡿࡇ࡜ࢆࡘࡁ࡜ࡵࡓࠋᖹᡂ 28 ᖺᗘࡢୗỈởἾ↝༷≀࡟㛵ࡍࡿ⌧ሙヨ㦂࡛ࡣࠊࡼࡾ㧗࠸㝖ཤ⋡ࢆᚓࡿࡓࡵ࡟ࠊ
ࠕ㧗ศᏊจ㞟๣࡜ࣇ࢙ࣟࢩ࢔ࣥ໬≀ඹỿἲࢆే⏝ࡋࡓࢭࢩ࣒࢘㝖ཤࡢຠ⋡໬ࠖࠊࠕࢥࣟ࢖ࢻ≧ࡢྍ⬟ᛶࡢ࠶ࡿᨺᑕᛶࢭࢩ࣒࢘ࡢ≉ᛶࠖ࡟ࡘ࠸࡚ࡉࡽ࡟᳨ウࡍࡿணᐃ࡛࠶ࡿࠋ
࢔ࢪ࢔㛤Ⓨ㏵ୖᅜࡢᆅୗỈ୰◉⣲ࡢၥ㢟࡜࣋ࢺࢼ࣒࡟࠾ࡅࡿⴭ⪅ࡽࡢྲྀࡾ⤌ࡳ㸸ᆅୗỈࡣࠊ⾲ὶỈ࡟ẚ࡭ࡿ࡜┦ᑐⓗ࡟ே㛫άື⏤᮶ࡢởᰁࡀᑡ࡞ࡃࠊ⃮ᗘࡶప࠸ඃࢀࡓỈ※࡛࠶ࡿࠋ࢔ࢪ࢔ࡢ㛤Ⓨ㏵ୖᅜ࡛
ࡣ⾲ὶỈࡣࡋࡤࡋࡤỈ㉁ởᰁࡀࡦ࡝࠸࠿⃮Ỉ࡛࠶ࡾࠊ(2)ୖグ (1)࡟࠾࠸࡚㣕⅊ࡢᏳᐃ໬ฎ⌮๓ࡢヨᩱ࡛ࡣࠊ ࡑࡢࡲࡲ⏕ά⏝Ỉ࡟౪ࡏࡿ≧ែ࡛ࡣ࡞࠸ࡓࡵᆅୗỈࢆ⏕ά⏝Ỉ࡟౑⏝ࡍࡿ౛ࡀከ࠸ࠋ
Ỉ⁐ᛶࡢࣇ࢙ࣟࢩ࢔ࣥ໬࣒࢝ࣜ࢘ࡢῧຍࡢࡳ࡛ᢳฟ
࡜ࡇࢁࡀࠊ≉࡟ࣄ࣐ࣛࣖࡸࢳ࣋ࢵࢺ࡞࡝࢔ࢪ࢔ࡢ
ᾮ୰ࡢ㔜㔠ᒓ࡜཯ᛂࡋ࡚㞴⁐ᛶࣇ࢙ࣟࢩ࢔ࣥ໬≀㘒୰ኸᒣሢࢆ※࡟ࡍࡿ࢔ࢪ࢔ࡢ኱Ἑᕝࡢ୰࣭ୗὶᇦ࡟
ሷࡀᙧᡂࡉࢀ࡚ࢭࢩ࣒࢘ࡢඹỿฎ⌮ࡀྍ⬟࡛࠶ࡗࡓࠋ㈿ᏑࡍࡿᆅୗỈࡣࠊᗈ⠊ᅖ࡟᭷ᐖ࡞ඖ⣲࡛࠶ࡿ◉⣲Ᏻᐃ໬ฎ⌮ᚋࡢởἾ➼ᢳฟᾮ࡛ࡣࠊ㕲࣭ࢽࢵࢣࣝ➼ࢆྵࡴ࡜࠸࠺ၥ㢟ࡀ࠶ࡿࠋࡇࡢᆅᇦ࡟ከ࠸⟶஭ᡞ㸦ᖏࡢῧຍࡀᚲせ࡛࠶ࡗࡓࠋ
Ỉᒙ࡟࣮࣎ࣜࣥࢢࢆࡋ࡚ᡭᢲࡋ࣏ࣥࣉ࡛Ỉࢆࡃࡳୖ(3) ᮾ໭ᆅᇦࡢୗỈฎ⌮ሙ࡛Ⓨ⏕ࡋࡓୗỈởἾ↝༷ࡆࡿ⡆᫆࡞஭ᡞ㸧➼࠿ࡽᆅୗỈࢆ࠼࡚࠸ࡿఫẸࡣࠊ≀࡟ࡘ࠸࡚ࠊᖹᡂ 25-27 ᖺࡢ㐣ཤ 3 ࠿ᖺ࡟ࢃࡓࡾ⌧↓ᶵ◉⣲ࡢ⤒ཱྀᦤྲྀ࡟ࡼࡿྛ✀ࡢ⅖⑕⑕≧࠿ࡽ⒴࡟
ሙヨ㦂ࢆᐇ᪋ࠊ≉࡟ୗỈởἾ⁐⼥㣕⅊࡟ࡘ࠸࡚Ỉ࡟⮳ࡿ៏ᛶ◉⣲୰ẘ࡟ࡼࡾࠊ⏒኱࡞೺ᗣ⿕ᐖࢆཷࡅ࡚
ࡼࡾ 35-70㸣࡜㧗࠸๭ྜ࡛ᨺᑕᛶࢭࢩ࣒࢘ࡀᢳฟࡉ
࠾ࡾࡑࡢᩘࡣᩘ༓୓ே࡟㐩ࡍࡿ࡜᥎ᐃࡉࢀࡿࠋ៏ᛶ
ࢀࡓࠋ୍᪉ࠊୗỈởἾࡢ↝༷㣕⅊࡟ࡘ࠸࡚ࡣỈ࡟ࡼࡿᢳฟ⋡ࡣ⁐⼥㣕⅊࡟ẚ࡭ప࠸⤖ᯝ࡜࡞ࡗࡓ㸦⾲ 1㸧ࠋ ◉⣲୰ẘࡣࠊᙜึࡣ⮬ぬ⑕≧ࡀ࠶ࡽࢃࢀࡎࠊᩘᖺ௨
ୖࡢ༢఩࡛ᚎࠎ࡟⑓ኚࡀ㐍⾜ࡍࡿࡓࡵࠊఫẸࡣ◉⣲↝༷㣕⅊࠿ࡽࡣࠊࢩࣗ࢘㓟ࡸሷ㓟࡛ࡣ 50-70㸣ࡢᨺᑕởᰁỈᦤྲྀࡢ༴㝤࡟┤ࡕ࡟Ẽ௜ࡁ࡟ࡃ࠸Ⅼࡶၥ㢟࡛ᛶࢭࢩ࣒࢘ࡀᢳฟࡉࢀࡓࠋᨺᑕᛶࢭࢩ࣒࢘ᢳฟ⋡ࡣ࠶ࡿࠋ࡞࠾◉⣲࡟ࡘ࠸࡚ WHO ࡢ㣧ᩱỈ㉁ᇶ‽ࡣởἾ๓ฎ⌮ᡭἲࡸ↝༷᮲௳࡟ࡼࡾኚືࡋࡓࠋࣇ࢙ࣟ
0.01mg/L࡜࡞ࡗ࡚࠸ࡿࡀࠊ౛࠼ࡤ➹⪅ࡽࡀࣇ࢕࣮ࣝ
ࢩ࢔ࣥ໬≀ඹỿἲ࡟ࡼࡿᢳฟᾮ୰ࡢᨺᑕᛶࢭࢩ࣒࢘
ࢻ࡜ࡋ࡚࠸ࡿ࣋ࢺࢼ࣒࡛ࡣ
1999 ᖺ᫬Ⅼࡢㄪᰝ࡛ࡣ
㝖ཤ⋡ࡣࠊ⁐⼥㣕⅊ࡣ 90%㉸࡜࡞ࡾࠊ↝༷㣕⅊࡛ 60%
⟶஭ᡞ
1228
ᮏ୰⣙
43㸣ࡀ
WHO
ᇶ‽ࢆ㉸࠼࡚࠸ࡓࠋ
ᙅ࡟࡜࡝ࡲࡗࡓࠋ
ࡉ࡚ࠊ➹⪅ࡽࡣ 2005 ᖺᗘ௨᮶㕲ࣂࢡࢸࣜ࢔⏕≀ℐ
㐣ἲ㸦௨ୗࠊ㕲ࣂࢡἲ࡜␎㸧࡟ࡼࡿᆅୗỈ୰ࡢ◉⣲࣭
Table 1 Leaching of radioactive cesium with water㕲࣭࣐࣭ࣥ࢞ࣥ࢔ࣥࣔࢽ࢔ྠ᫬㝖ཤࢩࢫࢸ࣒ࡢ㛤Ⓨfrom fly-ash samples from an incinerator and melting࡟ᦠࢃࡗ࡚ࡁࡓࠋࡁࡗ࠿ࡅࡣࠊୖグ㸲ᡂศࢆྵࡴᆅ
furnace treating sewage sludge (results of on-site test)ୗỈࢆจ㞟ỿẊฎ⌮ࡋ࡚⮬ᕫỈ࡜ࡋ࡚ά⏝ࡋ࡚࠸ࡿ㻯㼟㻙㻝㻟㻣
㻿㼍㼙㼜㼘㼑㻌
㼃㼍㼟㼠㼑㻌
㼀㼑㼟㼠㻌㼜㼑㼞㼕㼛㼐 㻯㼟㻙㻝㻟㻠ி㒔ᗓୗࡢ⮬἞యỈ㐨㒊㛵ಀ⪅࠿ࡽࡢෆࠎࡢせᮃ࡛㼗㻮㼝㻛㼗㼓
㼗㻮㼝㻛㼗㼓
㼠㼥㼜㼑㼓㼑㼚㼑㼞㼍㼠㼕㼛㼚࠶ࡗࡓࠋ௻ᴗ࣭⮬἞య࡜ඹྠ࡛ᮏἲࡢ㛤Ⓨࢆ㐍ࡵࡿ㻠㻚㻜㻤㻚㻡㻲㼘㼥㻌㼍㼟㼔㻌
㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻟㻞㻜㻝㻟㻌㼒㼍㼘㼘୰࡛ࠊᮏ᪉ἲࢆᡃࡀᅜࡢίỈ᪋タࡢࡳ࡞ࡽࡎࠊᆅୗ
㼒㼞㼛㼙㻌㻔㻜㻚㻠㻙㻜㻚㻣㻌㻑㻕㼕㼚㼏㼕㼚㼑㼞㼍㼠㼛㼞 㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻠㻞㻜㻝㻠㻌㼒㼍㼘㼘㻞㻚㻣㻤㻚㻝Ỉࡢ⮬↛◉⣲࡟ࡼࡿởᰁ࡟ᝎࡴ㏵ୖᅜ࡟㐺⏝ࡍࡿ᪉㻔㻝㻠㻌㻑㻕
ྥ࡟ィ⏬ࡀⓎᒎࡋࡓࠋ⌧ᅾࡶࠊி㒔ᗓୗ࠾ࡼࡧ㧗㏻
㻝㻚㻜㻠㻚㻟㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻡㻞㻜㻝㻡㻌㼒㼍㼘㼘㻔㻠㻑㻕Ỉ㏿ᗘ࡛ࡢ㕲ࣂࢡἲࡢࣃ࢖ࣟࢵࢺヨ㦂ࢆ⥅⥆ࡍࡿ࡜㻞㻜㻝㻟㻌㼒㼍㼘㼘㻜㻚㻢㻝㻚㻞㻮㼛㼠㼠㼛㼙㻌㼍㼟㼔㻌 㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻟࡜ࡶ࡟ࠊ࣋ࢺࢼ࣒࡛ࡢࣃ࢖ࣟࢵࢺヨ㦂ࢆ⤒࡚ Fig.2
㼒㼞㼛㼙㻌㻔㻜㻌䇵 㻢㻌㻑㻕㼕㼚㼏㼕㼚㼑㼞㼍㼠㼛㼞ࡢࡼ࠺࡟㕲ࣂࢡἲࡢᐇࣉࣛࣥࢺࢆ࣋ࢺࢼ࣒ࡢ㎰ᮧỈ㻹㼍㼥㻘㻌㻞㻜㻝㻟㻞㻜㻝㻠㻌㼒㼍㼘㼘㻝㻠㻚㻡㻠㻡㻚㻠㻲㼘㼥㻌㼍㼟㼔㻌㐨᪋タ࡟タ⨨ࡍࡿ࡟⮳ࡗࡓ㸦୕஭≀⏘⎔ቃᇶ㔠ࡢ᥼㻔㻡㻠㻙㻡㻤㻌㻑㻕㼒㼞㼛㼙㻌㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻟㻞㻜㻝㻟 㼒㼍㼘㼘㻟㻞㻚㻜㻢㻣㻚㻠㼙㼑㼘㼠㼕㼚㼓㻌
ຓ࡟ࡼࡿ㸧ࠋ
㻔㻠㻝㻙㻞㻢㻌㻑㻕㼒㼡㼞㼚㼍㼏㼑
㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻠㻞㻜㻝㻠㻌㼒㼍㼘㼘㻢㻚㻞㻝㻥㻚㻡ࡇࡇ࡛ࡣࠊ㕲ࣂࢡἲࡢཎ⌮ࢆ⡆༢࡟⤂௓ࡍࡿ࡜࡜
㻔㻢㻠㻙㻢㻥㻌㻑㻕ࡶ࡟ࠊ➹⪅ࡽࡢ⾜ࡗࡓ◊✲ࡢ୍౛࡜ࡋ࡚㹖⥺྾཰ศ㻞㻚㻡㻝㻜㻚㻝㻻㼏㼠㼛㼎㼑㼞㻘㻌㻞㻜㻝㻡㻞㻜㻝㻡㼒㼍㼘㼘
㻔㻡㻡㻙㻢㻜㻌㻑㻕
ගἲ(XAFS)ࢆ⏝࠸ࡓ㕲ࣂࢡἲࡢ◉⣲㝖ཤཎ⌮࡟ࡘ࠸࡚♧ࡍࡇ࡜࡜ࡍࡿࠋ
㕲ࣂࢡἲࡣࠊᆅୗỈ୰➼ࡢ⎔ቃỈ࡟⮬⏕ࡍࡿ㕲࣐(4) ୖグ(3)࡛ୗỈởἾ↝༷㣕⅊࠿ࡽࡢࢭࢩ࣒࢘ඹỿ
ࣥ࢞ࣥ㓟໬⣽⳦(㕲ࣂࢡࢸࣜ࢔)ࡀ⁐ゎᛶࡢ 2 ౯㕲ࡸ㝖ཤ⋡ࡀప࠸ཎᅉ࡜ࡋ࡚ࠊᨺᑕᛶࢭࢩ࣒࢘ࡢ୍㒊ࡀ࣐ࣥ࢞ࣥ➼ࢆ⏕≀㓟໬ࡍࡿ⌧㇟ࢆ฼⏝ࡋࡓࠊ⏝Ỉࡢᐇヨᩱࢆ⏝࠸ࡓ⌧ሙヨ㦂࡟ඛ❧ࡕࡗ࡚ࠊẖᖺࠊ┴ཬࡧ⎔ቃ┬࡟ᑐࡋ࡚◊✲ィ⏬᭩ࢆᥦฟࡋࠊཝᐦ࡞ᑂ
ᰝ࡜㛵ಀ㒊ᒁࡢᢎㄆࡢࡶ࡜Ᏻ඲࡟ヨ㦂ࢆ㐍ࡵ࡚࠸ࡿࠋ
ᖹᡂ 28 ᖺ 10 ᭶ึ᪪ࡲ࡛ࡢ➹⪅ࡽࡢᡂᯝࡣ௨ୗࡢ(1)㹼(4)ࡢ㏻ࡾ࡛࠶ࡿࠋ
(1) 㛵ᮾ௨໭ࡢࡈࡳ↝༷࠾ࡼࡧ⁐⼥㣕⅊㸦ᨺᑕᛶࢭࢩ
࣒࢘ࢆྵ᭷㸧ࡢỈࡲࡓࡣࢩࣗ࢘㓟ᢳฟᾮࠊ࡞ࡽࡧ࡟
ᨺᑕᛶࢭࢩ࣒࢘ࢆྵࡲ࡞࠸ୗỈởἾࡸᗫᲠ≀↝༷⅊ࡢỈࡲࡓࡣࢩࣗ࢘㓟ᢳฟᾮ㸦ࢭࢩ࣒࢘Ᏻᐃྠ఩యࢆ
100ȣg/L ࡲࡓࡣ Cs-137 ࢺ࣮ࣞࢧ࣮ࢆῧຍ㸧࡟ࠊࣇ࢙ࣟࢩ࢔ࣥ໬㘒ሷ㸦0.1mM, pH 3-5)࡜ࡢඹỿฎ⌮ࢆ⾜ࡗࡓ࡜ࡇࢁࠊࢭࢩ࣒࢘㝖ཤ⋡ 95㸣௨ୖࢆᚓࡓࠋᐊෆヨ㦂࡛ࡣ⌧ሙヨ㦂ࡼࡾ㧗࠸㝖ཤ⋡ࡀᚓࡽࢀࡿሙྜࡀ࠶
ࡾࠊࡑࡢཎᅉ࡟ࡘ࠸࡚ࡣ௨ୗ(4)࡟ㄽࡌࡿ஦㡯ࢆ᝿ᐃࡋ࡚࠸ࡿࠋ㻙 㻝㻜㻌㻙

㝖㕲࣭㝖࣐ࣥ࢞ࣥἲ࡜ࡋ࡚ᐇ⏝໬ࡉࢀࡓᢏ⾡࡛࠶ࡿࠋලయⓗ࡟ࡣࠊᚤ⏕≀ࢆಖᣢࡍࡿࡓࡵࡢࢁᮦࢆ඘࡚ࢇ
ࡋࡓࢁ㐣ሪ࡟ᆅୗỈ➼ࢆ㐃⥆㏻Ỉࡋࠊ㕲ࣂࢡࢸࣜ࢔
ࢆࢁ㐣ᒙୖ࡟ᐃ╔࣭⦾Ṫࡉࡏࡿࠋ㕲ࣂࢡࢸࣜ࢔ࡣᆅ
ୗỈ୰ࡢ⁐ゎᛶࡢ㕲ࡸ࣐ࣥ࢞ࣥࢆ㓟໬ࡋ࡚⢏Ꮚ≧≀㉁࡜ࡍࡿࠋࡇࢀࡽ⢏Ꮚ≧≀㉁ࡣ⳦యୖ࡟ỿ✚ࡉࢀࠊ࠶ࡿ࠸ࡣࢁᮦᒙ࡟ࡼࡾ≀⌮ⓗ࡟ࢁ㐣ࡉࢀ࡚ࠊ㝖ཤࡉࢀࡿࠋࡲࡓࠊཎỈ୰࡟࢔ࣥࣔࢽ࢔ࡀྵࡲࢀࡿሙྜࠊ
࢔ࣥࣔࢽ࢔ࡣℐ㐣ሪෆ࡟ᡂ❧ࡋࡓᚤ⏕≀⏕ែ⣔ࡢ୍㒊ࢆᵓᡂࡍࡿ◪໬⳦࡟ࡼࡾࠊ◪㓟࣭ள◪㓟࡟◪໬ࡉࢀࡿࠋࢁᮦࡣࠊ୍ᐃᮇ㛫ࡈ࡜࡟㏫ὶὙί㸦㏫Ὑ㸧ࡋࠊࢁ㐣㏿ᗘࢆ⥔ᣢࡍࡿ࡜࡜ࡶ࡟ࠊάᛶࡢ࠶ࡿ⳦ࢆࢁ㐣ሪ඲య࡟ศᕸࡉࡏࡿࠋ
㕲ࣂࢡἲࢆ◉⣲㝖ཤ࡟Ⓨᒎⓗ࡟㐺⏝ࡋࠊ㛗ᮇ࡟ࢃࡓࡿࣃ࢖ࣟࢵࢺヨ㦂࡟ࡼࡾࡑࡢᛶ⬟ࢆ❧ドࡋࡓⅬࡀᮏ◊✲ࡢ᪂つ࡞Ⅼ࡛࠶ࡿࠋ㕲ࣂࢡἲ࡟࠾ࡅࡿ◉⣲㝖ཤࡣࠊࢁ㐣ሪෆ࡛⏕≀Ꮫⓗ㓟໬࡟ࡼࡾ㐃⥆ⓗ࡟⏕ᡂࡉࢀࡿ㕲࣭࣐ࣥ࢞ࣥ㓟໬≀㸦௨ୗ㕲ࣂࢡࣇࣟࢵࢡ㸧࡟ࠊỈ୰ࡢ◉⣲ࡀ྾╔ࡉࢀࡿࡇ࡜࡛ᡂ❧ࡍࡿࠋࡇࢀ
ࡲ࡛ᆅୗỈ࡟◉⣲ࢆῧຍࡋ࡚ࡢヨ㦂ࡸࠊࡑࡢྍ⬟ᛶ࡟ࡘ࠸࡚ゝཬࡋࡓ◊✲ࡣᏑᅾࡍࡿࡶࡢࡢࠊᮏ᪉ἲࢆ
◉⣲㝖ཤ࡟ᑐࡋ࡚☜❧ࡍࡿࡓࡵࡢ㛤Ⓨࡣࡇࢀࡲ࡛༑
ศ࡟⾜ࢃࢀ࡚ࡇ࡞࠿ࡗࡓ⤒⦋ࡀ࠶ࡿࠋ

operation

removal㻌Run㻌RunFe As㻌
As Mn㻌
Mn NH4-N㻌 day m/
*㻌

d㻌

Aer
a-

Filter

tion㻌
tion㻌

Term

of theFilter㻌㻖㻖㻌

75%㻌
75% 69%㻌
69%

3 150 (n.a.) Plastic

2㻌 76% 72%

0%㻌
0%

2 150㻌 no Plastic㻌
(1.5) 㻌n.a. 㻌

3㻌 96% 71% 88%㻌 52%㻌88% 52%May -Aug.,
anf Nov.,
2006

Plas2 300 w (2.6)㻌 tic+sa
nd5㻌 98% 76% 72%㻌 n.a.
72%

1 600 w (4.5)㻌

8%㻌
8%

58%㻌
58%

Sep.-Dec.,
2005㻌

2㻌 150㻌w (3.6)㻌

4㻌 86% 89% 81%㻌 96%㻌81% 96%

97% 50% 12%㻌12% 24%㻌
24%

Nov. 2004***

Sep. and
Oct., 2006㻌

1.5m

Oct. 2007 Sep. 2008㻌

1 150㻌 w(4.2)㻌 sand9㻌 98% 66% 19%㻌 62%㻌 0.5 600
sand
19% 62%i (6.3) 㻌
10㻌
10㻌 97% 67% 8 %㻌% 44 %㻌
% 0.5 600
11㻌
11㻌 94% 22% -11%

Oct. 2008 Jan.2009

Max ability 600m3/᪥Operating for 12hr/day
Linear velocity : 65-80m/day(3.28)㻌 sand㻌12㻌
12㻌 79% 31% 34 %㻌
% n.a.㻌
n.a.㻌 0.33㻌 600㻌 w+p

(>5)㻌

13㻌
13㻌 92% 47% 45%

Raw water quality: Fe 12㼼2 mg/L , As:200㼼35 ˤJ/L

Fig. 2 The biological filtration system installed in water treatment plant in HaNam, Vietnam➹⪅ࡽࡢ⾜ࡗ࡚ࡁࡓ㕲ࣂࢡἲࣃ࢖ࣟࢵࢺヨ㦂ࡢヨ㦂ᡂ⦼ࢆ⾲ 2 ࡟♧ࡍࠋ᪂㩭࡞ᆅୗỈࡢ౑⏝ࡸ㏫Ὑ㛫㝸ࠊࢁᮦ㧗ࡀ㔜せ࡞㐠㌿ᅉᏊ࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
ࡉ࡚ࠊ≉࡟࢔ࢪ࢔ࡢ࠺ࡕ࢖ࣥࢻ࣭ࣂࣥࢢࣛࢹࢩࣗࡸ
࣋ࢺࢼ࣒࡞࡝㧗⃰ᗘࡢ◉⣲ࢆྵࡴᆅୗỈࢆ⏘ࡍࡿᆅᇦ࡛ࡣᆅୗỈ୰࡟  ౯◉⣲㸦ளࣄ㓟ࠊ$V 2+  ࠊ௨ᚋ$V ,,, 㸧ࡀከ࠸ࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋ$V ,,, ࡣ୰ᛶ௜㏆ࡢS+࡛ࡣ㠀ゎ㞳ࡢ୰ᛶศᏊ࡜ࡋ࡚Ꮡᅾࡍࡿࡓ
ࡵࠊ㕲ࡸ࢔࣑ࣝࢽ࣒࢘⣔ࡢจ㞟๣ࢆ⏝࠸ࡓจ㞟ỿẊࢁ㐣ἲࡸ⭷ࢁ㐣࡟࠾࠸࡚ࡶ㝖ཤ⋡ࡀᝏ࠸ࡇ࡜ࡀ᫂ࡽ
࠿࡟࡞ࡗ࡚࠸ࡿࠋࡑࡢࡓࡵḟளሷ⣲㓟ࢼࢺ࣒ࣜ࢘➼ࢆ 㓟 ໬ ๣ ࡜ ࡍ ࡿ ๓ 㓟 ໬ ࡟ ࡼ ࡗ ࡚ $V ,,, ࢆ ◉ 㓟$V 9 ࡟㓟໬ࡋ࡚࠿ࡽฎ⌮ࡍࡿࡢࡀ୍⯡ⓗ࡛࠶ࡿࠋ୍᪉ࠊⴭ⪅ࡽࡣཎỈ୰ࡢ◉⣲ࡢ኱㒊ศࡀ$V ,,, ࡛࠶㻙 㻝㻝㻌㻙

n.a.

1.0m

0.5 600 w+p

1.5 m

May 2011
to December 2012㻌
April 2013
to December 2013㻌

sand(5.9)㻌 sand㻌

April 2009
-Jul 2009
Nov 2010
to March
2011w(4.1)㻌 sand㻌

36 %㻌
% 0.25 600㻌 w

Oct., 2006㻌

July-Sep.
2007㻌

Plastic

Plastic
1150㻌 w(3.5)㻌 +zeolite8㻌 97% 71% 51%㻌 88%㻌 0.5 600
sand
51% 88%i (7.7) 㻌Filtration pond
(horizontal view)testheight㻌height㻌no1㻌 45% 0%

7㻌 95% 74%

Waterfall
aeration

Filtration pond(side view)

Table 2 Performance of the biological filtration pilot
plant

6㻌

Actual treatment system for domestic water supply
constructed in HaNam, Vietnam
Suctionof airࡿ࣋ࢺࢼ࣒ࡢ஭Ỉ࡟ᑐࡋ࡚㕲ࣂࢡἲࢆ㐺⏝ࡋࠊୖ㏙
ࡢࡼ࠺࡞◉⣲ࡢ๓㓟໬㐣⛬࡞ࡋ࡟㧗࠸㝖ཤ⋡ࢆ࠼ࡓࠋࡇࡢ⌮⏤࡜ࡋ࡚ⴭ⪅ࡽࡣ㕲ࣂࢡἲ࡛⏕ᡂࡉࢀࡿ㕲㓟໬≀ࡀ  ౯◉⣲࡟ᑐࡋ࡚㧗࠸㝖ཤ⬟ຊࢆᣢࡘࡇ࡜࡜⪃࠼ࠊXAFS㸦X-ray absorption fine structure㸧࡟ࡼࡿ
in-situ࡛ࡢ◉⣲ࡢ౯ᩘ ᐃἲ࡟ࡼࡿ◉⣲㝖ཤ㐣⛬ほࢆ⾜ࡗࡓࠋ

<1.5m

May 2014
to March
2015㻌

* Interval between backwashing (day)**Average DO in feed water (mg/L) in parentheses, no:no aeration w: water fall aeration, i: inline injector, w+p:
water fall aeration + aeration pump**Feed water was stored for 5 days
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⭘⒆⣽⬊≉࡟ Q ⭘⒆⣽⬊ࡢ TPZ ឤཷᛶࢆࡉࡽ࡟ቑᙉ
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ࡢࡼ࠺࡞ప㓟⣲⭘⒆⣽⬊࡟ࡣࠊ10B ໬ྜ≀ࠊ≉࡟ BPA
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BSH ࠿ࡽࡢ 10B ࡢ᪉ࡀ⭘⒆ෆ࡟ẚ㍑ⓗᆒ୍࡟ศᕸࡋࠊ
ྠࡌࡃࠊMTH ฎ⨨ే⏝㐃⥆ⓗ TPZ ᢞ୚ࡢే⏝ࡀࠊQ⭘⒆⣽⬊ไᚚࢆຍ࿡ࡋࡓᒁᡤ⭘⒆ไᚚࢆ᭱ࡶቑᙉࡉ
ࡏࡿ஦ࡶุ᫂ࡋࡓ[1]ࠋ
ࡑࡢᚋࠊᒁᡤ⭘⒆ไᚚࡢྥୖࡢࡓࡵࡢ⭘⒆ෆ㓟⣲ศᅽࢆኚ໬ࡉࡏࡿฎ⨨ࡀᒁᡤ⭘⒆࠿ࡽࡢ㐲㝸㌿⛣࡟ཬࡰࡍᙳ㡪ࢆㄪ࡭ࡓ⤖ᯝࠊ㏻ᖖᨺᑕ⥺↷ᑕ࡛ࡶ
BNCT ࡛ࡶࠊ⭘⒆ෆࡢᛴᛶప㓟⣲㡿ᇦࢆゎ㝖ࡍࡿ
nicotinamide, bevacizumab ➼ࡢే⏝ࡀᒁᡤ⭘⒆࠿ࡽࡢ
⫵㌿⛣⬟ࢆຠ⋡ࡼࡃᢚ࠼ࡓࠋ
ᒁᡤ⭘⒆ࡢไᚚ࡟኱ࡁࡃᙳ㡪ࡍࡿ἞⒪᢬ᢠᛶ࡛኱
ࡁ࡞៏ᛶప㓟⣲ࢆ᭷ࡍࡿ Q ⭘⒆⣽⬊ࡢไᚚ࡟ࡣࠊ៏
ᛶప㓟⣲㡿ᇦࡢゎ㝖ࡀࠊᒁᡤ⭘⒆࠿ࡽࡢ⫵㌿⛣ࡢᢚไ࡟ࡣࠊᛴᛶప㓟⣲㡿ᇦࡢゎ㝖ࡀ᭷⏝࡛࠶ࡾࠊᚑ᮶
ࡼࡾᣦ᦬ࡉࢀ࡚ࡁࡓࡼ࠺࡟ࠊᛴᛶཬࡧ៏ᛶࡢ཮᪉ࡢ
(= ༶ࡕࠊ඲య࡜ࡋ࡚ࡢ)ప㓟⣲㡿ᇦࡢไᚚࡢ㔜せᛶࡀᨵࡵ࡚♧ࡉࢀࡿ⤖ᯝ࡜࡞ࡗࡓ[2,4,5,7,11,12]ࠋ
ప㓟⣲ࢫࢺࣞࢫࡣࠊDNA ಟ᚟ࢆ␃ࡲࡽࡏࠊࡑࡢᚋ
ࡢ෌㓟⣲໬ࡣ DNA ࢆ㐣๫」〇ࡉࡏࡿࠋ஦ᐇࠊ⭘⒆ෆ
㓟⣲໬≧ἣࡣ↷ᑕᚋࡢ DNA ಟ᚟࡟ᙳ㡪ࢆ୚࠼ࠊ⭘⒆
ෆ࡛⧞ࡾ㏉ࡉࢀࡿప㓟⣲࡜෌㓟⣲໬(cycling hypoxia)ࡣࠊάᛶ㓟⣲✀(reactive oxygen species, ROS)ࢆⓎ⏕ࡉࡏࠊᛅᐇ࡞ DNA 」〇ࢆ㜼ᐖࡋࠊ㑇ఏⓗ୙Ᏻᐃᛶࢆᘬ
ࡁ㉳ࡇࡋࠊ✺↛ኚ␗ࠊᾐ₶ᛶ⋓ᚓࠊ㌿⛣⬟ୖ᪼࡟ࡶ⧅ࡀࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ⭘⒆ෆࡢᵝࠎ࡞㒊఩࡟୍᫬ⓗ࡟⏕ࡌࡿᛴᛶప㓟⣲㡿ᇦ࡛ࡣࠊ㑇ఏⓗ୙Ᏻᐃᛶࡸ㌿⛣⬟ࡀ㧗ࡃࠊࡑࡢᛴᛶప㓟⣲㡿ᇦࡢゎ㝖ࡀ㌿⛣⬟ࢆᢚไࡋࡓ࡜࠸࠺⤖ᯝࡣ㠀ᖖ࡟ྜ⌮ⓗ࡛࠶ࡾࠊ௒
ᚋࡣࠊ㔜⢏Ꮚ⥺↷ᑕࡶຍ࠼ࠊᒁᡤ⭘⒆࡬ࡢᨺᑕ⥺↷ᑕࡀࡶࡓࡽࡍᒁᡤ⭘⒆࠿ࡽࡢ㐲㝸㌿⛣⬟࡬ࡢᙳ㡪࡟㛵ࡍࡿໟᣓⓗ࡞ゎᯒࢆ⾜࠸ࡓ࠸ࠋ௚᪉ࠊᅛᙧ⭘⒆ෆࡢ≉ᐃ⣽⬊㞟ᅋ࡟㛵ࡍࡿゎᯒ࡛

ࡣࠊᢠ Pimonidazole ᢠయࢆ⏝࠸ࡓ៏ᛶప㓟⣲⣽⬊㡿ᇦࢆ㑅ᢥⓗ࡟ᶆ㆑ࡍࡿᡭἲࢆࠊ๓ฟࡢ Q ⭘⒆⣽⬊ࡢឤཷᛶࢆ㑅ᢥⓗ࡟᳨ฟྍ⬟࡞ᡭἲ࡟ే⏝ࡋࠊ㓟⣲໬
Q ⭘⒆⣽⬊㞟ᅋࡢឤཷᛶࢆ㑅ᢥⓗ࡟᳨ฟࡍࡿ᪂ࡓ࡞
ᡭἲࢆ㛤Ⓨࡋࡓࠋࡇࡢᡭἲ࡟ࡼࡾࠊ㓟⣲໬ Q ⭘⒆⣽⬊㞟ᅋࡢᨺᑕ⥺↷ᑕᚋࡢᅇ᚟⬟ࡀࠊQ ⭘⒆⣽⬊㞟ᅋ඲య࡜ࡋ࡚ࡢᅇ᚟⬟ࡼࡾ኱ࡁ࠸ࡇ࡜ࠊ⭘⒆⣽⬊ࡢ p53
status ࡀኚ␗ࡍࡿ࡜ࠊࡇࢀࡽࡢᅇ᚟⌧㇟⮬యࡀᑠࡉࡃ
࡞ࡿࡇ࡜࡞࡝ࡀุ᫂ࡋࡓࠋࡕ࡞ࡳ࡟ࠊࡇࢀࡽࡢᅇ᚟
⬟ࡣࠊ DNA㸰㔜㙐ษ᩿ࡢಟ᚟⤒㊰ࡢ࠺ࡕࡢ㠀┦ྠᮎ➃⤖ྜࢆ㜼ᐖࡍࡿ⸆๣ࡸ๓ฟࡢ TPZ ࡞࡝ࡢ㑅ᢥⓗప㓟⣲⣽⬊ẘ࡟ࡼࡗ࡚ࠊ࠿࡞ࡾຠ⋡ⓗ࡟ᢚไྍ⬟࡛࠶ࡿࡇ࡜ࡶุ᫂ࡋ࡚࠸ࡿࠋ㓟⣲໬ Q ⭘⒆⣽⬊ࡢࠕఇṆᛶࠖࠊࠕDNA ᦆയ࠿ࡽࡢ኱ࡁ࡞ᅇ᚟⬟ࠖࡣࠊࠕࢽࢵࢳ࢙࡟࠾ࡅࡿప㓟⣲ᛶࠖࢆ㝖ࡃ࡜ࠊ࠸ࢃࡺࡿ⒴ᖿ⣽⬊ࡢ(ᨺᑕ⥺⏕≀Ꮫⓗ)≉ᛶ࡟ࡶ㏆ఝࡋ࡚࠾ࡾࠊ⒴ᖿ⣽⬊࡜(㓟⣲໬) Q ⭘⒆⣽⬊࡜ࡢ㛵㐃ᛶ࡟㛵ࡍࡿゎᯒࡶᘬࡁ⥆ࡁ⾜࠸ࡓ࠸࡜⪃࠼࡚࠸ࡿ[3,6,8,9]ࠋ
BNCT ࡟≉໬ࡋࡓ◊✲࡜ࡋ࡚ࡣࠊ୍ࡘࡢ⭘⒆⣽⬊ෆ࡟࠾ࡅࡿ 10B ศᕸࢆ᳨ฟࡍࡿᡭἲࢆ㥑౑ࡋࠊẅ⣽⬊ຠᯝࢆỴᐃ࡙ࡅࡿ 10B ศᕸ㒊఩ࡢྠᐃࠊ10B ໬ྜ≀ᢞ୚᫬࡟࠾ࡅࡿ⸆๣࡞࠸ࡋ ⇕ฎ⨨ే⏝࡞࡝࡟ࡼࡿ
ẅ⣽⬊ຠᯝỴᐃ㒊఩࡟࠾ࡅࡿ 10B ศᕸ㔞ྥୖᡭἲࡢ
᳨⣴ࠊྍ⬟࡛࠶ࢀࡤࠊẅ⣽⬊ຠᯝỴᐃ㒊఩࡟࠾࠸࡚ᚲせ࡜ࡉࢀࡿ᭱ప 10B ศᕸ㔞ࡢỴᐃ࡜ࠊᢞ୚ࡉࢀࡿ
10
B ໬ྜ≀ࡢ≉ᛶ࡟኱ࡁࡃ౫Ꮡࡍࡿẅ⣽⬊ຠᯝỴᐃ㒊఩࡟࠾ࡅࡿ Compound Biological Effectiveness(CBE) factor ࡢ⟬ฟࡶヨࡳࡓ࠸[10,12]ࠋ
࠙ཧ⪃ᩥ⊩ࠚ
[1] S. Masunaga and Ono K. J. Radiat. Res., 43 (2002)
11-25.
[2] S. Masunaga, S, et al., Clin. Exp. Metastasis, 26(2009) 693-700.
[3] S. Masunaga, et al.. Radiat. Res., 174 (2010)459-466.
[4] S. Masunaga, et al., Br. J. Radiol., 83 (2010)776-784.
[5] S. Masunaga, et al., Br J Radiol., 84 (2011)
1131-1138.
[6] S. Masunaga, et al., World J. Oncol., 2 (2011) 1-9.
[7] S. Masunaga, et al., Br. J. Radiol., 85 (2012)249-258.
[8] S. Masunaga, et al., Br. J. Radiol., 86 (2013) 86.
doi: 10.1259/bjr.20120302.
[9] S. Masunaga, et al., J. Radiat. Res., 54 (2013)221-229.
[10] S. Masunaga, et al., Springer Plus, 3 (2014) 128.
doi:10.1186/2193-1801-3-128.
[11] S. Masunaga, et al., World J Oncol., 5(2014)
155-165.
[12] S. Masunaga, et al., Int J Radiat Biol., 92 (2016)
187-194. doi: 10.3109/09553002.2016.

Analysis of the characteristic of quiescent tumor cell population from the viewpoint of controlling local tumor, repressing distantmetastasis and involving in cancer stem cell
Shin-ichiro MasunagaKoji Ono
smasuna@rri.kyoto-u.ac.jp

㻙 㻝㻠㻌㻙

㻔㻼㻝㻕 㖄 ࣅࢫ࣐ࢫจᅛ㐣⛬ࡢࣃࣝࢫ୰ᛶᏊ࢖࣓࣮ࢪࣥࢢ
㸦ி኱ཎᏊ⅔ࠊ໭኱㝔ᕤ ࠊཎᏊຊᶵᵓ 㸧‫ۑ‬ఀ⸨኱௓ࠊ㰺⸨Ὀྖࠊబ⸨༤㝯 ࠊ⠛ཎṊᑦ 㸰㸬ᐇ㦂㸸Fig. 1 ࡟ᐇ㦂⿦⨨ࡢᴫ␎ᅗࢆ♧ࡍࠋࢸࢫࢺ
㒊ࡣ 80×80×10 mm ࡢ SUS304 〇ࡢᐜჾ࡛࠶ࡾࠊLBEࢧࣥࣉࣝࢆᑒධࡋ࡚࠶ࡿࠋࢸࢫࢺ㒊ୖ㒊࡟ຍ⇕⏝ࣄ࣮ࢱ㸦200 W2㸧ࠊୗ㒊࡟෭༷⏝ࡢࣄ࣮ࢺࢩࣥࢡ࠾ࡼ
ࡧ✵෭⏝ࣇ࢓ࣥࢆྲྀࡾ௜ࡅࡓࠋࢸࢫࢺ㒊ୖ㒊ቨ㠃ᗘࡣ ᗘㄪ⠇ჾࢆ⏝࠸࡚ไᚚࡋࡓࠋࡲࡓࠊࢸࢫࢺ㒊࡟ࡣഃ㠃࠿ࡽ 5ᮏࡢ Kᆺ⇕㟁ᑐࢆᤄධࡋ࡚࠶ࡾࠊLBEෆ ᗘศᕸࡢ ᐃࢆ⾜ࡗࡓࠋ ᗘࢧࣥࣉࣜࣥࢢ㏿ᗘࡣ 1 Hz ࡛࠶ࡿࠋࣃࣝࢫ୰ᛶᏊ࢖࣓࣮ࢪࣥࢢᐇ㦂ࡣJ-PARC BL22 RADEN ࡛⾜ࡗࡓࠋ2 ḟඖ TOF ᝟ሗࢆᚓࡿࡓࡵ࡟ GEM ᆺ᳨ฟჾ (nGEM, Bee Beans Technologies ♫〇)ࢆ౑⏝ࡋࡓࠋᮏ᳨ฟჾࡢ✵㛫ศゎ⬟ࡣ
0.8 mm/pixelࠊ᧜ᙳ㡿ᇦࡣ 100100 mm ࡛࠶ࡿࠋ㸱㸬⤖ᯝ㸸Fig. 2 ࡟ࣈࣛࢵࢢ࢚ࢵࢪ࢖࣓࣮ࢪࣥࢢ⤖ᯝࡢ୍౛ࢆ♧ࡍࠋ⏬ീࡢ⃰ῐࡣ࠶ࡿ୰ᛶᏊ࢚ࢿࣝࢠ࣮
㡿ᇦ࡟࠾ࡅࡿ LBEᅛᾮ┦ࡢ㏱㐣ࢫ࣌ࢡࢺࣝࡢ㐪࠸ࢆ⾲ࡋ࡚࠸ࡿࠋᮏ᮲௳ࡣ ᗘ୍ᐃ᮲௳㸦Tup=220 °C,
Tbtm=35 °C㸧࡛࠶ࡾࠊLBE ࡢ⼥Ⅼ㸦Tmelt=124.7 °C㸧ࡣࢸࢫࢺ㒊ෆ࡟Ꮡᅾࡋ࡚࠸ࡿࠋࡑࡢࡓࡵࠊࢸࢫࢺ㒊ୖ㒊ࡀᾮ┦ࠊୗ㒊ࡀᅛ┦࡜࡞ࡿࠋFig. 2 ࠿ࡽࡶ⏬ീ୰ኸ௜㏆࡟ࢥࣥࢺࣛࢫࢺࡢᕪࡀ☜ㄆ࡛ࡁࠊᅛᾮ⏺㠃ࡀᏑᅾࡋ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡿࠋࡲࡓࠊᅛ┦ෆ࡟࠾࠸࡚ࡳ
ࡽࢀࡿࢥࣥࢺࣛࢫࢺࡢ㐪࠸ࡣࠊจᅛ㏿ᗘ࡟ࡼࡿ⤖ᬗᵓ㐀ኚ໬ࢆ♧ࡋ࡚࠸ࡿࠋ௒ᚋࠊ⤖ᬗᵓ㐀ゎᯒ➼࡜ྜࢃࡏ࡚ヲ⣽࡟ㄪ࡭ࡿࡇ࡜࡛ࠊLBE ࡢ⁐⼥࣭จᅛ≉ᛶࡢ⌮ゎ࡟ࡘ࡞ࡀࡿ࡜⪃࠼ࡽࢀࡿࠋ

Pulsed neutron imaging of lead-bismuth solidification process
Daisuke Ito, Yasushi Saito, Hirotaka Sato, Takenao Shinohara
LWRG@rri.kyoto-u.ac.jp

㻙 㻝㻡㻌㻙

Front view
Tup

Side view
Cartridge heaters

Heating
sectionT1
T2

LBE region

80mm

㸯㸬ࡣࡌࡵ࡟㸸㖄ࣅࢫ࣐ࢫඹᬗྜ㔠㸦LBE㸧ࡣࠊప
⼥Ⅼ࣭㧗ἛⅬࢆ᭷ࡋࠊ໬Ꮫⓗ࡟Ᏻᐃ࡛࠶ࡿࡇ࡜࠿ࡽࠊ
ຍ㏿ჾ㥑ືࢩࢫࢸ࣒㸦ADS㸧ࡢ᰾◚○ࢱ࣮ࢤࢵࢺව
෭༷ᮦ࡜ࡋ࡚᭷ᮃどࡉࢀ࡚࠸ࡿ[1]ࠋࡋ࠿ࡋ࡞ࡀࡽࠊ
㐣෭༷࡟ࡼࡿ LBE ࡢจᅛࡸ㓟໬≀࡞࡝ࡢᯒฟࡣࠊὶ
㊰㛢ሰࢩࣅ࢔࢔ࢡࢩࢹࣥࢺࢆᘬࡁ㉳ࡇࡍྍ⬟ᛶࡀ࠶ࡿࠋࡑࡢࡓࡵࠊADS ࡢᏳ඲ᛶ☜ಖࡢࡓࡵ࡟ࡣ LBE
ࡢ⁐⼥࣭จᅛ≉ᛶࢆ༑ศ࡟⌮ゎࡍࡿᚲせࡀ࠶ࡿࠋ୍
⯡ⓗ࡟ࠊᅛᾮ㛫ࡢ┦ኚ໬≉ᛶ࡟ࡘ࠸࡚ࡣ㠀ᐃᖖ⇕ఏᑟ᪉⛬ᘧࢆゎࡃࡇ࡜࡛࠶ࡿ⛬ᗘண ྍ⬟࡛࠶ࡿࡀࠊ
ᅛయ LBE࡟࠾࠸࡚ࡣจᅛ㏿ᗘࡢ㐪࠸࡟ࡼࡾ⤖ᬗᵓ㐀ࡀኚ໬ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠾ࡾ[2]ࠊṇ☜࡞ண ࡢࡓࡵ࡟ࡣ⤖ᬗᵓ㐀ࡢ㐪࠸࡟ࡼࡿ≀ᛶ್ኚ໬≉ᛶ࡜┦ኚ໬ᣲືࡢ཮᪉ࢆ⌮ゎࡍࡿࡇ࡜ࡀ㔜せ࡜࡞ࡿࠋᮏ◊✲࡛ࡣࠊLBE ࡢ⁐⼥࣭จᅛ㐣⛬࡟ᑐࡋ࡚ࣃࣝࢫ୰ᛶ
Ꮚ࢖࣓࣮ࢪࣥࢢ[3]ࢆ㐺⏝ࡋࠊᚓࡽࢀࡓ㏱㐣ࢫ࣌ࢡࢺࣝࡢ 2 ḟඖศᕸ࠿ࡽᅛᾮ⏺㠃఩⨨ࢆ≉ᐃࡍࡿ࡜࡜ࡶ
࡟ࠊ⤖ᬗᵓ㐀ࡢ㐪࠸࡟ࡼࡿ┦ኚ໬≉ᛶ࡬ࡢᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ

T3
T4
80mm

Cooling
section

T5

10mm

Fan

Tbtm

Heat sink

Fig. 1. Experimental setup for pulsed neutron imaging
of LBE solidification process.

Fig. 2. Bragg-edge imaging result
Tbtm =35 °C, λ=5.0~6.2 Å).

(Tup=220°C,㸲㸬ࡲ࡜ࡵ㸸ᮏ◊✲࡛ࡣ LBE ࡢ┦ኚ໬≉ᛶࢆ᫂ࡽ࠿
࡟ࡍࡿࡓࡵࠊࣃࣝࢫ୰ᛶᏊ࢖࣓࣮ࢪࣥࢢࢆ⏝࠸ࡓ
LBE จᅛ㐣⛬ࡢྍど໬ィ ࢆ⾜࠸ࠊ୰ᛶᏊ㏱㐣ࢫ࣌ࢡࢺࣝࡢ㐪࠸࠿ࡽᅛᾮ⏺㠃఩⨨ࡢ≉ᐃࢆ⾜ࡗࡓࠋ௒ᚋࠊ⤖ᬗᵓ㐀ゎᯒࡸ㠀ᐃᖖ⇕ఏᑟゎᯒ࡜ࡢẚ㍑࡟ࡼ
ࡾࠊ≀ᛶ್ኚ໬࡟ࡼࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿᚲせࡀ࠶ࡿࠋཧ⪃ᩥ⊩[1] J. Zhang, Adv. Eng. Mater., 16 (2014) 349-356.
[2] O. Takada, et al., J. Nucl. Mater., 398 (2010) 129-131.
[3] H. Sato, et al., Mater. Trans., 52-6 (2012) 1294-1302.

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ࡓ /%( ࡢ⇕ὶື࡟㛵ࡍࡿ᪤Ꮡࡢ◊✲࡛ࡣ㸪⃿ࢀᛶࢆࣃ࣓࣮ࣛࢱ࡜ࡋࡓ◊✲ࡣ⾜ࢃࢀ࡚࠸࡞࠸㸬ࡑࡇ࡛㸪ᮏ◊✲࡛ࡣ /%(❅⣲஧┦ὶࢆᑐ㇟࡜ࡋ࡚㸪ὶ㊰ቨ㠃⃿ࢀᛶࢆኚ໬ࡉࡏࡓ㝿ࡢ࣎࢖ࢻ⋡࠾ࡼࡧẼἻ㢖ᗘ࡞࡝ࡢᇶ♏ࢹ࣮ࢱࡢィ ࠾ࡼࡧࡑࡢ஧┦ὶ≉ᛶࢆᐇ㦂ⓗ࡟᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬㻔㻼㻠㻕 Two-phase flow structure in a simulated debris bed(ி኱࢚ࢿ, ி኱ཎᏊ⅔ 1㸧‫ۑ‬Milka Navaࠊఀ⸨኱௓ 1ࠊ㰺⸨Ὀྖ 1
1.

Introduction
Sodium-cooled Fast Reactors (SFR) has a high potential possibility for new Nuclear Reactor projects, however Risk
Reduction Management requires that all Severe Accident (SA)possibilities can be addressed and properly counter measured.
In case of a Core Disruptive Accident (CDA) the In Vessel Retention (IVR) constitutes an acceptable path to control the consequences of a SA, following the event progression of a hypothetical CDA [1] and depending on the core design most of themelt fuel would be moved to the lower plenum of the vessel in a
fragmented shape called debris [1,2], this debris can be cooled
there in a pool condition. The remaining melted fuel (debris) inthe core region needs also to be cooled to avoid a re-criticality
issue; the coolant debris interaction creates a two-phase flow inporous media interaction scenario, this phenomenon become
then the key to understand and evaluate the possibility of a
re-criticality issue that could threat the IVR success.
This study aims to evaluate the characteristics of thesodium vapor/liquid-debris, through simulation of this phenomenon by substituting sodium with water and recreating thedebris with different sizes glass beads; within this simulated
environment, experiments to characterize the pressure drop andvoid fraction under different debris sizes, fluid velocities (liquid,gas) can be performed and the results lead to the creation of adatabase that can be used as reference to predict the progressionof the long-term heat removal for the remaining debris fuel inthe core.
2.

Experiment
For simplicity, preliminary experiments were performed with air-water-porous media system instead of sodium-vapor/liquid-debris. Glass beads (0.4, 0.6, 0.8, 1, 2, 3, 4 & 5mm in diameter) were packed in a round tube to function as
porous media. To establish a reference frame of the experiment,
extensive review of published papers with similar research goal
(two-phase flow in porous media) was done, and from these
papers, for single phase flows Ergun correlation (Eq. 1) waschosen to be compared with experimental data [3]:'PL

150 1  G
d s2G 32

P f uf 

1.75 1  G Uu 2f
G 3ds(1)

where ǻP represents the pressure difference across the packed
bed, L the height of the porous bed, ds the particle diameter, ȡthe density of the fluid, uf the fluid velocity, ȝf the viscosity of
the fluid and į represents the porosity, respectively.
Experimental set up consisted of a closed loop of 5
cm internal diameter acrylic pipe that allows water flow from
Two-phase flow structure in a simulated debris bed.
Milka NavaDaisuke ItoYasushi Saito
nava.hebi.42m@st.kyoto-u.ac.jp

㻙 㻝㻤㻌㻙

Fig. 1 Simulation of pressure drop on single phase flow and experimental results.

down to top and test section, which was located at 30cm upwardfrom the inlet equipped with pressure tappings for pressure drop
measurement. The differential pressure sensor used can read up
to 10 kPa and the height of the packed bed for this measurement
was 10 cm.
3. Results
The calculated results of Eq. (1) are presented in Fig.
1. Dashed-dotted lines denote present experimental results andsolid lines the predictions by Ergun equation for various beads
sized from 0.4 to 5 mm in this figure. It can be observed that thepressure drop increases as the glass spherical beads size getsmaller. More experiments would be necessary to accumulate
data of all the simulated glass beads diameters.
For the two-phase flow, there has not been a clear
agreement in the existing correlations[4,5], but, Saada correlation shows a relatively close agreement with experimental results [3]. Pressure drop database in two-phase flow will be constructed to contrast with this correlation and develop more accurate correlation.

References[1] T. Suzuki et al., A scenario of core disruptive accident forJapan sodium-cooled fast reactor to achieve in-vessel
retention. J. of Nuclear Science & Technology, vol. 51, No. 4,
p. 493-513. (2014).
[2] K. Kamiyama et al., An Experimental Study on Heat
Transfer from a Mixture of Solid-fuel and liquid steel during
Core Disruptive Accidents in Sodium-Cooled Fast Reactors.
NUTHOS-10. (2014)[3] M. Jamialahmadi et al., Pressure drop, gas hold-up and heattransfer during single and two-phase flow through porous
media. : Int. J. of Heat and Fluid Flow 26. (2005)[4] R. Clavier et al., Experimental study of single-phasepressure drops in coarse particle beds. Chicago IL.:NURETH-16. (2015)[5] N. Chikhi et al., Evaluation of an effective diameter tostudy quenching and dry-out of complex debris bed. Annalsof Nuclear Energy 74. (2014)㻔㻼㻡㻕 γ ⥺↷ᑕ࡟ࡼࡿࣛࢵࢺỈᬗయ α-࠾ࡼࡧ β-ࢡࣜࢫࢱࣜࣥࡢ㓟໬ࠊ⬺࢔࣑ࢻ໬࠾ࡼࡧ␗ᛶ໬➼ࡢ⩻ヂᚋಟ㣭ࡢ㎿㏿ LC-MS/MS ศᯒ㸦ி኱ཎᏊ⅔ࠊᗈ኱║ 1ࠊᖇி኱ 2㸧‫ۑ‬㔠ோồࠊ㰺⸨๛ࠊ㔠ᮏᑦᚿ 1ࠊ⸨஭ᬛᙪ 2ࠊ ⸨஭⣖Ꮚ㸯㸬ࡣࡌࡵ࡟㸸Ỉᬗయࡢࢡࣜࢫࢱࣜࣥ୰࡛ࡣຍ㱋ࠊ⣸እ⥺ࠊᨺᑕ⥺↷ᑕ࡟ࡼࡾࡑࡢᵓᡂ࢔࣑ࣀ㓟ṧᇶࡀ㓟໬ࠊ⬺࢔࣑ࢻ໬ࠊ␗ᛶ໬࡞࡝ࠊᵝࠎ࡞ಟ㣭ࢆཷࡅ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗ࡚ࡁࡓࠋᡃࠎࡣ௨๓ࡢ◊✲࡛ࢡࣜࢫࢱࣜࣥ⁐ᾮ࡟ 0.5 - 2.0 kGy ࡢ γ ⥺↷ᑕࢆ⾜࠺࡜ࢺࣜࣉࢺࣇ࢓ࣥ㸦Trp㸧ṧᇶࡢ㓟໬ࡸ࢔ࢫࣃࣛ
ࢠࣥ㓟ṧᇶࡢ␗ᛶ໬ࡀಁ㐍ࡍࡿࡇ࡜ࢆ☜ㄆࡋࡓࠋᮏ
◊✲࡛ࡣࣛࢵࢺỈᬗయ࡟ప⥺㔞ࡢ γ ⥺ࢆ↷ᑕࡋࠊ࢔࣑ࣀ㓟ṧᇶࡢಟ㣭㒊఩ࢆỴᐃࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ㸰㸬ᐇ㦂㸸5-500 Gy ࡢ γ ⥺ࢆ 4 㐌㱋ࡢࣛࢵࢺỈᬗయ࡟↷ᑕࡋࠊ↷ᑕᚋ࣍ࣔࢪ࢙ࢼ࢖ࢬࡋࠊ㐲ᚰศ㞳࡟ࡼࡾྍ⁐ᛶ(WS)⏬ศ࡜୙⁐ᛶ(WI)⏬ศ࡟ศ㞳ࡋࡓࠋ୧⏬ศࢆࡑࢀࡒࢀ trypsin ฎ⌮ࡋࠊ඲ࢱࣥࣃࢡ㉁ࢆ࣌ࣉ
ࢳࢻ᩿∦໬ࡋࡓࠋᚓࡽࢀࡓ୧⏬ศ⏤᮶ࡢࢺࣜࣉࢩࣥ
ࣇࣛࢢ࣓ࣥࢺࢆ one-shot LC/MS/MS ୍࡛ᩧศᯒࡋࡓࠋ
࣌ࣉࢳࢻྠᐃཬࡧ Cry ୰ࡢ࢔࣑ࣀ㓟ṧᇶࡢ⩻ヂᚋಟ㣭࡟㛵ࡋ࡚ࡣ Proteome Discoverer ࡟ࡼࡾゎᯒࢆ⾜ࡗࡓࠋ㸱㸬⤖ᯝ㸸LC-MS/MS ゎᯒࡢ⤖ᯝࠊ4 㐌㱋ࡢࣛࢵࢺỈᬗయ࡬ࡢ 5 Gy ࡢ γ ⥺↷ᑕ࡟ࡼࡗ࡚ α-ࠊβ-ࢡࣜࢫࢱࣜࣥࡢ࢔࣑ࣀ㓟ṧᇶࡣ㓟໬ࡉࢀ࡚࠾ࡽࡎࠊγ-ࢡࣜࢫࢱ࡛ࣜࣥࡣ㓟໬ࡀ᳨ฟࡉࢀࡓࠋα-࠾ࡼࡧ β-ࢡࣜࢫࢱࣜࣥࡣࠊγ-ࢡࣜࢫࢱࣜࣥ࡜ẚ㍑ࡋ࡚ γ ⥺↷ᑕ࡟ᑐࡋ࡚㓟໬ࡉࢀ࡟ࡃ࠸ࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡲࡓࠊ50
Gy ௨ୖࡢ γ ⥺↷ᑕ࡟ࡼࡗ࡚ࠊα-ࠊβ-ཬࡧ γ‐ࢡࣜࢫࢱࣜࣥࡢ MetࠊTrpࠊHis ṧᇶࡀ㓟໬ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿
࡜࡞ࡗࡓࠋࡉࡽ࡟ࠊ୙⁐ᛶ⏬ศࡢࢱࣥࣃࢡ㉁࡟࠾ࡅ
ࡿ㓟໬㒊఩ࡢᩘࡣࠊྍ⁐ᛶ⏬ศࡢࢱࣥࣃࢡ㉁࡟࠾ࡅ
ࡿᩘࡼࡾࡶከ࠿ࡗࡓࠋᨺᑕ⥺↷ᑕ࡟ࡼࡗ࡚⏕ࡌࡓྛࢡࣜࢫࢱࣜࣥࡢ࢔࣑ࣀ㓟ṧᇶࡣࠊࣄࢺⓑෆ㞀Ỉᬗయ୰ࡢࢡࣜࢫࢱࣜࣥࡢ㓟໬㒊఩࡜୍⮴ࡋ࡚࠸ࡓࠋࡇࢀ
ࡽ࢔࣑ࣀ㓟ṧᇶࡣศᏊ⾲㠃࡟᭚㟢ࡋ࡚࠸ࡿࡇ࡜ࡼࡾ
㓟໬ⓗࢫࢺࣞࢫࢆཷࡅࡸࡍ࠸࡜⪃࠼ࡽࢀࡓࠋࡇࡢ⤖ᯝ࠿ࡽ γ ⥺↷ᑕࡀຍ㱋ᛶⓑෆ㞀ࡢⓎ⑕ᶵᵓࢆゎ᫂ࡍࡿୖ࡛᭷⏝࡞ࢶ࣮࡛ࣝ࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ

One shot LC-MS/MS analysis of post-translational modifications including oxidation, deamidation, and isomerization, of rat lens
α-and β-crystallins induced by γ-irradiation
Ingu Kim, Takeshi Saito, Takashi Kanamoto, Norihiko Fujii, Noriko Fujii
in9-kou@rri.kyoto-u.ac.jp

㻙 㻝㻥㻌㻙

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10

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ù¶Þ[1] ÏÌd, #*, 54 (2015) 616-620.
[2] Y. Oba et al., ISIJ Int., 52 (2012) 457-463.
[3] J. Ilavsky et al., J. Appl. Cryst., 45 (2012) 1318-132.

Grand opening of small-angle X-ray scattering instrument equipped with Mo target
Yojiro Oba, Nobuhiro Sato, Rintaro Inoue, Masaaki Sugiyama
oba@rri.kyoto-u.ac.jp

㻙 㻞㻜㻌㻙

-1㻔㻼㻣㻕 Cu ⥺※ X ⥺ᑠゅᩓ஘⿦⨨ࡢඹྠ฼⏝㛤ጞ㸦ி኱ཎᏊ⅔㸧‫ۑ‬బ⸨ಙᾈࠊ኱ሙὒḟ㑻ࠊ஭ୖ೔ኴ㑻ࠊᮡᒣṇ᫂㸯㸬ࡣࡌࡵ࡟㸸ࢤࣝࡸࢥࣟ࢖ࢻ࡞࡝ࡢࢯࣇࢺ࣐ࢱ࣮
ࡸࠊࢱࣥࣃࢡ㉁ࡸ DNA ࡞࡝ࡢ⏕యศᏊ࡞࡝ࡢᶵ⬟ࡸ≀ᛶࢆゎ᫂ࡍࡿࡓࡵ࡟ࡣࠊศᏊࡸࡑࡢ㞟ྜయࡀ⧊ࡾ
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ࡀࠊX ⥺࣭୰ᛶᏊᑠゅᩓ஘ἲ(SAXS, SANS)ࡣࠊࢼࣀ
࣓࣮ࢺࣝ࠿ࡽ࣐࢖ࢡ࣓࣮ࣟࢺࣝ࡟ཬࡪ㠀ᬗᛶ࡛୙ᆒ
୍࡞ᵓ㐀ࢆᾮయ୰࡟࠾࠸࡚ホ౯ྍ⬟࡞ᵓ㐀ゎᯒἲ࡛࠶ࡾࠊ௚ࡢᡭἲ࡟ࡣぢࡽࢀ࡞࠸≉㛗ࢆ᭷ࡋ࡚࠸ࡿࠋ ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤ࡟࠾࠸࡚ࡣࠊ20 ᖺ᮶ࠊ◊✲ཎ Ꮚ ⅔ KUR ࢆ ୰ ᛶ Ꮚ ※ ࡜ ࡍ ࡿ SANS ⿦ ⨨KUMASANS ࢆ㛤Ⓨ࣭㐠⏝ࡋඹྠ฼⏝࡟౪ࡋ࡚ࡁࡓࠋ
ࡇࢀࡣᅜෆ࡟ᩘᑡ࡞࠸ SANS ⿦⨨ࡢ 1 ࡘ࡜ࡋ࡚ࠊ᪥ᮏࡢᑠゅᩓ஘◊✲࡟ከ኱࡞㈉⊩ࢆࡋ࡚ࡁࡓࡀࠊ୍᪉
࡛ࠊ㛗᫬㛫 ᐃࡀᚲせ࡛࠶ࡗࡓࡾࠊKUR ࡢ㐠㌿≧ἣ࡟ᙳ㡪ࢆཷࡅࡓࡾࡍࡿ࡞࡝ࡢ⌮⏤࡟ࡼࡾࠊᡭ㍍࡟฼
⏝ྍ⬟࡞≧ἣ࡟ࡣ࡞࠿ࡗࡓࠋࡲࡓࠊSAXS ࡟㛵ࡋ࡚ࡣࠊ㧗࢚ࢿࣝࢠ࣮ຍ㏿ჾ◊✲ᶵᵓࡢ Photon Factoryࡸ SPring-8 ࡞࡝ࡢ኱ᆺᨺᑕග᪋タࡢ㧗㍤ᗘ X ⥺※ࢆ฼⏝ࡋࡓ SAXS ࣅ࣮࣒ࣛ࢖ࣥࡀ฼⏝ྍ⬟࡛࠶ࡿࡀࠊ
㐲㝸ᆅ࡟㉱ࡃᚲせࡀ࠶ࡾࠊࣅ࣮࣒ࣛ࢖ࣥࡢᩘࡀ㝈ࡽࢀ࡚࠸ࡿࡓࡵࣅ࣮࣒ࢱ࢖࣒ࡢ⋓ᚓࡶᐜ࡛᫆ࡣ࡞࠸ࠋ
୍᪉ࠊᐇ㦂ᐊ⏝ࡢᑠᆺ SAXS ⿦⨨ࡣࠊX ⥺ࡢᙉᗘࡣᙅ࠸ࡶࡢࡢࠊᚲせ࡞᫬࡟ࡍࡄ࡟ ᐃྍ⬟࡛࠶ࡿ࡜࠸
࠺࣓ࣜࢵࢺࡀ࠶ࡾࠊSANS ⿦⨨ࡸᨺᑕග SAXS ⿦⨨࡜ࡢ」ྜ฼⏝࡟ࡼࡗ࡚ࠊ◊✲ࡢྍ⬟ᛶࡀ኱ࡁࡃᗈࡀ
ࡿࠋࡑࡇ࡛ᡃࠎࡣࠊ᪂ࡓ࡟ X ⥺※ࡢ␗࡞ࡿ 2 ྎࡢᐇ㦂ᐊ⏝ SAXS ⿦⨨ࢆᑟධࡋࠊᮏᖺᗘࡼࡾ㐠⏝ࢆ㛤ጞࡋࡓࠋᮏⓎ⾲࡛ࡣ㖡(Cu)ࢱ࣮ࢤࢵࢺ X ⥺※ࡢ SAXS⿦⨨ࡢᴫせ࡟ࡘ࠸࡚ሗ࿌ࡍࡿࠋ
㸰㸬⿦⨨ࡢᴫせ㸸 ᑟධࡉࢀࡓ⿦⨨ࡣ Cu ᅇ㌿ᑐ㝜ᴟᘧ X ⥺Ⓨ⏕⿦⨨㸦Max. 40kV, 30mA㸧ࢆഛ࠼ࡓ(ᰴ)ࣜ
࢞ࢡ〇㧗ศゎ⬟ᑠゅᩓ஘ศගჾ NANOPIX ࡛࠶ࡿ㸦ᅗ 1㸧ࠋྠ᫬࡟ᑟධࡉࢀࡓ Mo ⥺※ SAXS ⿦⨨࡜ẚ㍑ࡋ࡚ X ⥺ࡢἼ㛗ࡀ㛗࠸ࡓࡵࠊ㕲࡞࡝ࡢ㔠ᒓᮦᩱ࠶ࡿ࠸ࡣ୍㒊ࡢ᭷ᶵ⁐፹࡞࡝ X ⥺㏱㐣⋡ࡢᑠࡉ࠸ヨᩱࢆ㝖࠸࡚ࠊᗈࡃỗ⏝࡟ ᐃࡀྍ⬟࡛࠶ࡾࠊ୺࡟ࢯࣇ
ࢺ࣐ࢱ࣮ࡸ⏕యᮦᩱࡢゎᯒ࡟฼⏝ࡉࢀࡿணᐃ࡛࠶ࡿࠋ
ᐤ⏕ᩓ஘ࡢపῶࡉࢀࡓ Ge 〇 2 ࣆ࣮ࣥ࣍ࣝගᏛ⣔࡜᪂タィ࣑࣮ࣛ࡟ࡼࡾヨᩱ఩⨨࡛ࡢ X ⥺ᙉᗘࢆቑᙉࡍࡿ
࡜࡜ࡶ࡟ࠊ ᪂㛤Ⓨࡢ㧗ᛶ⬟ 2 ḟඖ༙ᑟయ᳨ฟჾ
HyPix-6000 ࢆ⏝࠸ࡿࡇ࡜࡛ࠊ㧗ឤᗘ㧗ศゎ⬟ ᐃࢆᐇ⌧ࡋ࡚࠸ࡿࠋࡲࡓࠊᘬࡁฟࡋᘧ┿✵ᩓ஘ᵴ㸦ᅗ 2㸧
࡟ࡼࡾ 601400 mm ࡢ㛫࡛࣓࢝ࣛ㛗ࡢኚ᭦ࢆ⡆༢࡟⾜࠺ࡇ࡜ࡀྍ⬟࡛࠶ࡾࠊᗈ࠸ᩓ஘࣋ࢡࢺࣝ⠊ᅖ࡛ࡢᐃࢆᐜ᫆࡟ࡋ࡚࠸ࡿ㸦࢝ࢱࣟࢢ௙ᵝୖࡣ 0.0025 4ࠋࢩࢫࢸ࣒඲యࡣࠊ࡯࡜ࢇ࡝ࡀ PC ไᚚ࡜࡞ࡗ
ύ-1㸧࡚࠾ࡾࠊ࣮ࣜࣔࢺ࣓ࣥࢸࢼࣥࢫࡀྍ⬟࡛࠶ࡿࠋ㸱㸬 ᐃ౛࡜௒ᚋࡢ฼⏝ணᐃ㸸 ᅗ 3 ࡟ᮏ⿦⨨࡛ࡢᐃ౛ࢆ♧ࡍࠋᕥࡣගᏛ⣔ࡢ㍑ṇ⏝࡟⏝࠸ࡿ࣋࣊ࣥ㓟㖟ࡢ ᐃ౛࡛࠶ࡿࠋ2 ࡘࡢ␗࡞ࡿ࣓࢝ࣛ㛗㸦1300 ࠾ࡼࡧ 400 mm㸧࡛ࡢ ᐃࢆྜ୍ࡍࡿࡇ࡜࡛ࠊ0.007–0.6
ύ ࡢᗈ࠸ q ⠊ᅖࡀ ᐃྍ⬟࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡿࠋ
ྑࡣࠊࢱࣥࣃࢡ㉁ αA-ࢡࣜࢫࢱࣜࣥ࣍ࣔ࢜ࣜࢦ࣐࣮
㸦ศᏊ㔞 480kDa, ⃰ᗘ 0.9 mg/ml, ⁐ᾮ㔞 25 μl㸧ࡢᩓ஘᭤⥺࡛࠶ࡿࠋࡇࡢ࡜ࡁࡢ ᐃ᫬㛫ࡣࢃࡎ࠿ 10 ศ㛫࡛࠶ࡾࠊ᮲௳ࡀᩚ࠼ࡤࠊ▷᫬㛫࡛ࣀ࢖ࢬࡢᑡ࡞࠸㉁ࡢ㧗࠸ᩓ஘ࢹ࣮ࢱࡀᚓࡽࢀࡿࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
 2016 ᖺ 4 ᭶ࡢ㐠⏝㛤ጞ௨㝆ࠊࡇࢀࡲ࡛࡟ࠊࡍ࡛࡟
10 ௳㏆ࡃࡢඹྠ◊✲ࡀᐇ᪋ࡉࢀ࡚࠸ࡿࡀࠊ᮶ᖺᗘ௨
㝆ࡣඹྠ฼⏝⿦⨨࡜ࡋ࡚ᮏ᱁ⓗ࡞ඹྠ฼⏝ᐇ㦂ࢆጞࡵࠊࡶ࠺ 1 ྎࡢ Mo ⥺※ SAXS ⿦⨨࡜ྜࢃࡏ࡚ࠊ20௳௨ୖࡢඹྠ฼⏝◊✲ࡀ⾜ࢃࢀࡿணᐃ࡛࠶ࡿࠋ

Fig. 1.

Cu ⥺※ X ⥺ᑠゅᩓ஘⿦⨨ NANOPIX

Fig. 2.

Fig. 3. (ᕥ) ࣋࣊ࣥ㓟㖟ࡢᩓ஘᭤⥺ࠋ2 ࡘࡢ␗࡞ࡿ࣓࢝ࣛ㛗࡛ ᐃࡋࡓࢹ࣮ࢱࢆྜ୍ࠋ(ྑ) αAࢡࣜࢫࢱࣜࣥ࣍ࣔ࢜ࣜࢦ࣐࣮ࡢᩓ஘᭤⥺ࠋ

A new small-angle X-ray scattering instrument with a Cu-target source started operation
Nobuhiro Sato, Yojiro Oba, Rintaro Inoue Masaaki Sugiyama
sato-n@rri.kyoto-u.ac.jp

㻙 㻞㻝㻌㻙

ᘬࡁฟࡋᘧ┿✵ᩓ஘ᵴ㻔㻼㻤㻕 ୰ᛶᏊ↷ᑕᶍᨃ⇞ᩱࢹࣈࣜ࠿ࡽࡢ᰾✀⁐ฟᣲື-ヨᩱㄪ〇㸦ி኱㝔ᕤࠊᮾ໭኱ከඖ◊ 㸧‫ۑ‬ᆏᮏᓧ୍ࠊబࠎᮌ㝯அࠊᑠᯘ኱ᚿࠊ⛅ᒣ኱㍜ ࠊ᱒ᓥ㝧 ࠊబ⸨ಟᙲ 㸯㸬⫼ᬒ⚟ᓥ➨୍ཎᏊຊⓎ㟁ᡤ஦ᨾ࡟࠾࠸࡚ࡣእ㒊㟁※ࢆ
႙ኻࡋࠊ෭༷୙⬟࡜࡞ࡗࡓ⅔ᚰࡣ࣓ࣝࢺࢲ࢘ࣥ࡟⮳ࡗࡓࠋ⁐⼥ࡋࡓ⇞ᩱࡣ =U ྜ㔠〇ࡢ⇞ᩱ⿕そ⟶ࢆ⁐࠿ࡋ࡚᱁⣡ᐜჾ࡟㈏㏻ࡋࡓ ࣓ࣝࢺࢫ࣮ࣝ ࠋࡑࡢࡓࡵࠊ
₃ฟࡋࡓ⇞ᩱࡣ᱁⣡ᐜჾୗࡢࢥࣥࢡ࣮ࣜࢺ➼࡜᥋ゐࡋࠊ0&&, ┦஫స⏝ 0ROWHQ&RUH&RQFUHWH,QWHUDF
WLRQ ࡟ࡼࡾࠊ⁐⼥⇞ᩱ࡜௚ࡢᵓ㐀ᮦཬࡧࢥࣥࢡ࣮ࣜ
ࢺࡀඹ࡟෭࠼ᅛࡲࡗࡓ⇞ᩱࢹࣈࣜࡀᙧᡂࡉࢀࡓ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ ⇞ᩱࢹࣈࣜࡣ㧗ᨺᑕ⥺㔞ୗࡢ⎔ቃ࡟࠶ࡾࠊᐜ᫆࡟
㏆࡙ࡅ࡞࠸ࡓࡵࠊศᯒࡢࡓࡵࡢࢧࣥࣉࣜࣥࢢࡍࡽᮍ
ࡔ࡟ᅔ㞴࡞≧ἣ࡛࠶ࡿࠋᚑࡗ࡚ࢹࣈࣜㅖ≀ᛶࡢヲ⣽ࡣᢕᥱࡉࢀ࡚࠾ࡽࡎࠊᑗ᮶ⓗ࡞ฎ⌮ฎศࡢィ⏬ࡶỴࡲࡗ࡚࠸࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋᡃࠎࡢࢢ࣮ࣝࣉࡣࡇ
ࢀࡲ࡛ࠊ82 ࡜⅔ෆ࡛⏝࠸ࡽࢀ࡚࠸ࡿྛ✀ᵓ㐀ᮦᩱᡂศࡢΰྜ≀ࢆຍ⇕ฎ⌮ࡋࡓᶍᨃ⇞ᩱࢹࣈࣜࢆㄪ〇ࡋࠊࡑࡢ≉ᛶࡢ⌮ゎࢆ㐍ࡵࡿ࡜࡜ࡶ࡟ࠊ᰾✀ࡢỈ࡬ࡢ⁐ฟᣲື࡟ࡘ࠸᳨࡚ウࡋ࡚ࡁࡓ>@ࠋᮏ◊✲࡛ࡣࠊ⇞ᩱࢹࣈࣜࡢ࠺ࡕ≉࡟ࢥࣥࢡ࣮ࣜࢺ࡜ࡢ᥋ゐ࡟ࡼࡗ࡚⏕ࡌࡓ 0&&, ⇞ᩱࢹࣈࣜࠊ࠾ࡼࡧ⇞ᩱ⿕そ⟶࡜ࡢ཯ᛂࡢ
᭷↓࡟╔┠ࡋࠊࡇࢀࡽࡢᡂศẚࢆኚ࠼ࡓᶍᨃ⇞ᩱࢹࣈࣜࢆㄪ〇ࡋࡓࠋࡲࡓࠊΰㄪ〇ࡋࡓᅛ┦ヨᩱ୰ࡢ໬ྜ≀࠾ࡼࡧ⤖ᬗᵓ㐀ࡀΰྜᡂศẚ࡟ࡼࡗ࡚࡝ࡢࡼ࠺
࡟ኚ໬ࡍࡿ࠿ࢆㄪ࡭ࡓࠋ
㸰㸬ᐇ㦂⇞ᩱᡂศ࡜ࡋ࡚ 82 ࠊࢥࣥࢡ࣮ࣜࢺᡂศ࡜ࡋ࡚
&D&2 6L2ࠊ⇞ᩱ⿕そ⟶ᡂศ࡜ࡋ࡚ =U2 ࢆ⏝࠸ࡓࠋࡇࢀࡽࢆᡤᐃࡢẚ⋡࡛ࡵࡢ࠺ங㖊ࢆ⏝࠸࡚☻○ΰྜࡋࡓࠋヨᩱࡢ 8 ࡟ᑐࡍࡿ &D ࡢཎᏊᩘẚࠊ8 ࡟ᑐࡍࡿ=U ࡢẚࠊ6L ࡟ᑐࡍࡿ &D ࡢẚࡣࠊ&D8 ẚ㸸
ࠊ=U8 ẚ㸸ࠊ࠾ࡼࡧ &D6L ẚ㸸 ࡛࠶ࡿࠋ=U8 ẚ  ࡣ⇞ᩱ⿕そ⟶  ᮏ࠶ࡓࡾ࡟ྵࡲࢀࡿ 8 ࡜ =U ࡢࣔࣝẚ࡟㏆࠸್>@ࠊ&D6L ẚ ࡣᐇࢭ࣓ࣥࢺ୰ࡢ &D2 ࡜ 6L2 ẚ࡟㏆࠸್࡜ࡋ
ࡓ>@ࠋࡇࡢΰྜ≀ࢆ▼ⱥ࣮࣎ࢺ࡟⛣ࡋࠊ▼ⱥ཯ᛂ⟶࡟ᑟධࡋ Υࡢ +$U ࡢ㑏ඖ㞺ᅖẼ࠶ࡿ࠸ࡣ
2$U ࡢ㓟໬㞺ᅖẼୗ࡛  ᫬㛫ຍ⇕ࡋࡓࠋ ຍ⇕ฎ⌮ࡋࡓᶍᨃ⇞ᩱࢹࣈࣜࢆ✵෭ࡋࡓᚋࠊ; ⥺ᅇᢡἲࢆ⏝࠸࡚ᅛ┦ゎᯒࢆ⾜ࡗࡓࠋ; ⥺ࡣ &X.Ș
N9P$ ࢆ⏝࠸ࠊᅇᢡゅࡣ r࠿ࡽ rࡲ࡛ࡢ༊㛫ࢆ rPLQ ࡢ㉮ᰝ㏿ᗘ࡛ゎᯒࢆ⾜ࡗࡓࠋ㸱㸬⤖ᯝ࡜⪃ᐹ㑏ඖ㞺ᅖẼ࡛ຍ⇕ฎ⌮ࢆ⾜ࡗࡓヨᩱ࡛ࡣ 82 ࡀᨭ㓄ⓗ࡞ᅛ┦࡜ࡋ࡚ぢࡽࢀࠊ8 ࡣΰྜᡂศ࡜໬ྜ≀ࢆᙧᡂࡏࡎࠊ82 ࡢ᱁Ꮚᐃᩘ࡟ࡶኚ໬ࡣぢࡽࢀ࡞࠿ࡗࡓࠋ
᪤ ◊✲࡟ࡼࢀࡤࠊ82 ࡜ =U2 ࢆ  ࡛ΰྜࡋࡓヨᩱࢆᮏᐇ㦂࡜ྠ᮲௳࡛ຍ⇕ࡋࡓ㝿ࠊᅛ⁐యᙧᡂࡀ☜ㄆࡉࢀ࡚࠸ࡿ>@ࠋࡑࡢࡓࡵ 82 ࡜ =U2 ࢆ  ࡢẚ࡛ΰྜࡋࠊ㑏ඖ㞺ᅖẼ࡛ຍ⇕ฎ⌮ࢆ⾜ࡗࡓヨᩱ࡛ࡶᅛ⁐యࡀᙧᡂࡉࢀࡿ࡜ᮇᚅࡋࡓࡀࠊᅛ⁐యᙧᡂࡣ☜ㄆ࡛ࡁ࡞࠿ࡗࡓࠋࡇࢀࡣ࣓࢝ࣀࢣ࣑࢝ࣝฎ⌮ࡢ᭷↓࡟ࡼࡿΰྜࡢ⛬ᗘࡀ␗࡞ࡿࡓࡵ࡜᥎ᐹࡉࢀࡿࠋ
 82=U2&D&26L2 ࢆΰྜࡋࠊ㓟໬㞺ᅖẼ࡛ຍ⇕ฎ⌮ࢆ⾜ࡗࡓヨᩱ࡟㛵ࡍࡿᅛ┦ゎᯒࢆ⾜ࡗࡓ࡜ࡇࢁࠊᅛ┦୰࡟ࡣ &D ࡜ 8 ࡢ  ඖ⣔㓟໬≀ࡢᙧᡂࡀ☜ㄆ
ࡉࢀࠊ8 ࡣ  ౯࡟㓟໬ࡀ㐍⾜ࡋࡓࠋࡑࡢ໬ྜ≀ཬࡧ⤖ᬗᵓ㐀ࡣ &D8 ẚࡀቑຍࡍࡿ࡟ࡘࢀ &D82 FXELF ࠊ&D82 WULJRQDO ࠊ&D82 ࡜ኚ໬ࡋࡓࠋࡲࡓࠊ=U ࢆྵࡴᅛ┦ࡣᨭ㓄ⓗ࡛࡞࠸ࡇ࡜ࡀศ࠿ࡗࡓࠋࡇࡢࡇ࡜࠿
ࡽࠊ=U ࡜ẚࡋ࡚ &D ࡢ᪉ࡀ࢘ࣛࣥ࡜ࡢ໬ྜ≀ࢆᙧᡂࡋࡸࡍࡃࠊࡲࡓ &D ࡜ࡢ໬ྜ≀ᙧᡂࡣ 8 ࡢ㓟໬ࢆಁ㐍ࡍࡿྍ⬟ᛶࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
 &D8 ẚࢆ ࠊ=U8 ẚࢆ  ࡜ࡋࡓ 82=U2
&D&26L2 ࡢΰྜ≀ࢆ㓟໬㞺ᅖẼ࡛ຍ⇕ฎ⌮ࡋࡓヨᩱ࡛ࡣ &D82 FXELF ࡢࣆ࣮ࢡࡀ㧗ゅ᪉ྥ࡟ࢩࣇࢺࡋ
ࡓࡀࠊ=U ࢆྵࡴᅛ┦ࡣ☜ㄆࡉࢀ࡞࠿ࡗࡓࡇ࡜࠿ࡽࠊ
=U2 ࡢῧຍ࡟ࡼࡾ &D82 FXELF ࡢ᱁Ꮚᐃᩘ࡟ఱࡽ࠿
ࡢኚ໬ࡀ⏕ࡌ࡚࠸ࡿࠋ୍᪉ࠊ&D8 ẚࢆ  ࠾ࡼࡧ ࡟ቑࡸࡋࡓヨᩱ࡛ࡣ &D82 WULJRQDO ࡸ &D82
ࡀྠᐃࡉࢀࡓࡀࠊࡑࢀࡒࢀࣆ࣮ࢡࡢࢩࣇࢺࡣぢࡽࢀࡎࠊࡲࡓ࣐࢖ࢼ࣮⤌ᡂ࡜ࡋ࡚ࡢᅛ┦୰࡟ =U2 ࡸ&D=U2 ࡀ ぢࡽ ࢀࡓ ࠋ ᮏ ᐇ㦂 ᮲ ௳ୗ ࡟࠾ ࠸࡚ ࡣ ࠊ&D82 WULJRQDO ࠾ࡼࡧ &D82 ࡣ =U ࡢῧຍ࡟ࡼࡿᙳ
㡪ࢆཷࡅࡎࠊ=U ࡢᙳ㡪ࢆཷࡅࡿࡢࡣ &D82 FXELF ࡟㝈ࡽࢀ࡚࠸ࡿࠋ
ཧ⪃ᩥ⊩[1] Takayuki Sasaki, Yuu Takeno, Taishi Kobayashi, Akira
Kirishima and Nobuaki Sato., “Leaching behavior of
gamma-emitting fission products and Np from neutron-irradiated UO2-ZrO2 solid solutions in non-filtered surface
seawater (2015)” Journal of Nuclear Science and Technology, 53, p303-p311.
[2] ᗈ℩ຮࠊᅵ஭Ⲯ୍͆᰾⇞ᩱᕤᏛࡢᇶ♏ ➨ 2 ᅇ㍍Ỉ⅔⇞ᩱ(1)ࠊ᪥ᮏཎᏊຊᏛ఍ㄅࠊVol.46ࠊNo.7ࠊ
p.412͇
ࠊ2004[3] ୍⯡♫ᅋἲேࢭ࣓ࣥࢺ༠఍ ໬Ꮫศᯒ⏝ࢭ࣓ࣥࢺᶆ‽≀㉁ 211S (ᬑ㏻࣏ࣝࢺࣛࣥࢻࢭ࣓ࣥࢺ)ࠊ
http://www.jcassoc.or.jp/cement/4pdf/jj2b_02.pdf

Leaching behavior of elements from neutron-irradiated simulated fuel debris -sample preparationShunichi Sakamoto, Takayuki Sasaki, Taishi Kobayashi, Daisuke Akiyama, Akira Kirishima Nobuaki Satosakamoto.shunichi.26x@st.kyoto-u.ac.jp

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㻔㻼㻥㻕 J-PARC/MLF BL06 ୰ᛶᏊඹ㬆ࢫࣆ࢚ࣥࢥ࣮ศගჾ⩌(VIN ROSE)࡜
୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨࡢ⌧≧ 2
㸦ி኱⅔ࠊ㧗࢚ࢿᶵᵓ ࠊ⌮◊ ࠊ໭኱ ࠊ㟁ᶵ኱ 㸧‫ۑ‬᪥㔝ṇ⿱ࠊᑠ⏣㐩㑻ࠊྜྷỌᑦ⏕ࠊ㔠ᒣ㞞ဢࠊᕝ➃♸ྖࠊ㐲⸨ோ ࠊᒣ⏣ᝅྐ ࠊ⣽␊ᣅஓ ࠊṊ⏣᫴ ࠊ㒌Ụ ࠊᒣᙧ㇏ ࠊྂᆏ㐨ᘯ ࠊ᳃⏣᫴ஓ ࠊ℩ᡞ⚽⣖ ‫࡟ࡵࡌࡣۑ‬୰ᛶᏊࡣࢼࣀᵓ㐀ࡢ᫬㛫̿✵㛫㡿ᇦࡢ୧᪉ࢆࣉࣟ
࣮ࣈฟ᮶ࡿᕼ᭷࡞⢏Ꮚ࡛࠶ࡾࠊ୰ᛶᏊࢫࣆ࢚ࣥࢥ࣮
ἲࡣ✵㛫ࢫࢣ࣮࡛ࣝ 0.1ࠥ100nm ࡢ✵㛫㡿ᇦࢆࣆࢥ⛊㹼ࢧࣈ࣐࢖ࢡࣟ⛊ࢆ࢝ࣂ࣮࡛ࡁࡿࠋࢫࣆ࢚ࣥࢥ࣮
ἲࡣ୰ᛶᏊࢫࣆࣥ࡜࠸࠺⮬⏤ᗘࢆᑟධࡋࠊࢫࣆࣥࡢ
఩┦ࢆ⢭ᐦไᚚࡍࡿࡇ࡜࡛ࠊධᑕ୰ᛶᏊࡢ࢚ࢿࣝࢠ
࣮ศゎ⬟࡟ࡼࡗ࡚ ᐃྍ⬟࡞࢚ࢿࣝࢠ࣮ศゎ⬟ࡀไ㝈ࡉࢀࡿࡇ࡜↓ࡃࠊ㧗࢚ࢿࣝࢠ࣮ศゎ⬟࠿ࡘ㧗୰ᛶᏊᙉᗘࢆྠ᫬࡟ᐇ⌧ࡍࡿࠋி ኱ ̿ KEK 㐃 ᦠ ࡢ ඖ ࠊ KEK-S ᆺ ㄢ 㢟(2009S07,2014S07)ࡢᨭ᥼ࢆཷࡅࠊJ-PARC/MLF BL06
ࣅ࣮࣒ࣛ࢖ࣥࢆ᏶ᡂࡉࡏࠊ୰ᛶᏊඹ㬆ࢫࣆ࢚ࣥࢥ࣮
⿦⨨⩌:VIN ROSE(The VIllage of Neutron ResOnanceSpin Echo spectrometers)ࢆ㛤Ⓨ୰࡛࠶ࡿࠋVIN ROSE
ࡣ MIEZE ᆺ࡜ NRSE ᆺ࡜࠸࠺ 2 ࡘ≉ᚩࡢ␗࡞ࡿࢫࣆ
࢚ࣥࢥ࣮ศගჾࢆᣢࡘࠋMIEZE(Modulated IntEnsity
by Zero Effort)ᆺ࡛ࡣ ㏻ᖖࡢࢫࣆ࢚ࣥࢥ࣮⿦⨨࡛ࡣᅔ㞴࡞ヨᩱ࡟ᙉ࠸☢ሙࢆ࠿ࡅࡿ➼ࡢヨᩱ⎔ቃࡢ⮬⏤ᗘࡀ㨩ຊ࡛࠶ࡾࠊపศᏊཬࡧ☢ᛶࡢࢲ࢖ࢼ࣑ࢵࢡࢫࢆࠊNRSE(Neutron Resonance Spin Echo)ᆺ࡛ࡣ (⏕య)
㧗ศᏊࡢ㧗ศゎ⬟ࢲ࢖ࢼ࣑ࢵࢡࢫࢆࢱ࣮ࢤࢵࢺ࡜ࡋ
࡚࠸ࡿࠋ‫ۑ‬MIEZE ศගჾࡢ⌧≧࡜㞟ග NRSE ศගჾ
ி኱⅔ࡢࢢ࣮ࣝࣉࡣࠊ㣕⾜᫬㛫ἲ(TOF)ࢆ฼⏝ࡍࡿ
TOF-MIEZE ศගἲ࡛ࡣࠊࣃࣝࢫᖜࡢ᫬㛫ࡀ▷࠸ࡇ࡜㸦ࢩ࣮ࣙࢺࣃࣝࢫ࡛࠶ࡿࡇ࡜㸧ࡀ⿦⨨ࡢ㧗ᗘ໬࡟ࡶ㠀ᖖ࡟᭷฼࡛࠶ࡿࡇ࡜Ⓨぢࡋࠊࡑࡢᐃᘧ໬࡜☜ㄆᐇ㦂ࢆ⾜ࡗࡓ [1]ࠋ ࡉࡽ࡟ヲ⣽࡞᳨ウࢆ BL06 ࡛⾜ࡗ࡚࠾ࡾࠊࡑࡢ⤖ᯝࢆㄽᩥᢞ✏‽ഛ୰࡛࠶ࡿࠋࡲࡓᐇ
ຠ᣺ືᩘ 200kHz ࡛㧗ࢥࣥࢺࣛࢫࢺ࡞ MIEZE ࢩࢢࢼࣝࢆྲྀᚓࡋࠊ☢ᛶⷧ⭷ࡢࢲ࢖ࢼ࣑ࢡࢫ◊✲➼ࡢ
TOF-MIEZE ศගἲࢆά࠿ࡍヨᩱ ᐃࢆ㛤ጞࡋ࡚࠸ࡿࠋTOF-MIEZE ศගἲࡣᙉ☢ሙࢆྵࡴࠊᚑ᮶ࡢࢫࣆ
࢚ࣥࢥ࣮⿦⨨࡛ࡣ㞴ࡋ࠸ヨᩱ⎔ቃ࡛ࡢ ᐃࢆྍ⬟࡜ࡍࡿࡀࠊ㧗࢚ࢿࣝࢠ࣮ศゎ⬟࡟ࡣ㝈⏺ࡀ࠶ࡿࠋࡑࡢ
ࡓࡵࠊ㧗ศゎ⬟ ᐃࡣ NRSE ࡀᢸᙜࡍࡿࡀࠊࡑࡢ㐩ᡂ࡟ࡣࠊヨᩱ࡟ࡼࡿᚤᑡ࡞ᩓ஘ゅࡢኚ໬࡟ࡼࡿࢫࣆ
ࣥࡢ఩┦ࢆ⿵ṇࡍࡿࡓࡵࡢ఩┦⿵ṇࢹࣂ࢖ࢫࢆ☜❧ࡍࡿᚲせࡀ࠶ࡿࠋࡇࡇ࡛఩┦⿵ṇࢹࣂ࢖ࢫ࡟ᅇ㌿ᴃ෇యࢫ࣮ࣃ࣮࣑࣮ࣛࢆ⏝࠸ࡿࡇ࡜࡛ヨᩱ࡛ࡢ㞟ගࡶฟ᮶୍࡚▼஧㫽࡛ࡣ࠶ࡿࡀࠊᅇ㌿ᴃ෇య㞟ග࣑࣮ࣛࡢᡂຌ౛ࡣᮍࡔ↓࠸ࠋᡃࠎࡣ㔠ᒓẕᮦࢆ⏝࠸࡚ࡇࡢၥ㢟࡟ᣮᡓࡋ࡚࠸ࡿࠋ

‫ۑ‬㔠ᒓᇶᯈ࡟ࡼࡿ୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨ
VIN ROSE ࡟㛵ࢃࡽࡎࠋJ-PARC ➼ࡢࣃࣝࢫ୰ᛶᏊ
※࡛ࡣ TOF ࢆ⏝࠸࡚ᗈ࠸Ἴ㛗ᖜࢆᢅ࠺ࡓࡵࠊࢫ࣮ࣃ
࣮࣑࣮ࣛࡣᚲ㡲࡞ගᏛࢹࣂ࢖ࢫ࡛࠶ࡿࠋ㧗ᛶ⬟࡞ࢫ࣮ࣃ࣮࣑࣮ࣛࡢᐇ⌧࡟ࡣࠊᒙ㛫ࡢᣑᩓࡔࡅ࡛࡞ࡃࠊ
ᇶᯈࡢ⾲㠃⢒ࡉࡶ 0.3nm ⛬ᗘ௨ୗ࡟ᢚ࠼ࡿᚲせࡀ࠶ࡿࠋࡇࡢไ⣙ࡢࡓࡵࠊ୰ᛶᏊᑟ⟶⏝ࡢ࣑࣮ࣛ࡟ࡣࠊ
࢞ࣛࢫࡸࢩࣜࢥࣥࡢᖹᯈᇶᯈࡀ฼⏝ࡉࢀࡿࠋࡋ࠿ࡋ
ࡇࢀࡽࡢ⣲ᮦࢆࠊᖹ⁥࡞ࡲࡲ᭤⋡ࡢ኱ࡁ࡞ᅇ㌿య࡟ຍᕤࡍࡿࡇ࡜ࡣ኱ኚᅔ㞴࡛࠶ࡿࠋ௒ᅇᚲせ࡞ᅇ㌿ᴃ෇య࣑࣮ࣛࡣ㛗ࡉ 1m ㏆ࡃ࡜ᕧ኱࡛࠶ࡾࠊࡲࡓᩓ஘
ゅࢆ࢝ࣂ࣮ࡍࡿࡓࡵ࡟ࡣࠊ᭱⤊ⓗ࡟ࡣ 10 ᮏ㏆࠸ᩘࡀ
ᚲせ࡜࡞ࡗ࡚ࡋࡲ࠺ࡓࡵࠊ〇సᮇ㛫࡜ࢥࢫࢺࡶ㠀ᖖ࡟㔜せ࡜࡞ࡿࠋ
ࡇࡇ࡛㔠ᒓࢆẕᮦࡍࡿࡇ࡜࡛ࠊᶵᲔຍᕤ⏝ࡢ NC
ຍᕤᶵ࡛ͤࡢ〇సࡀྍ⬟࡜࡞ࡾࠊ๻ⓗ࡞〇సᮇ㛫▷⦰࡜ࢥࢫࢺ๐ῶࡀྍ⬟࡜࡞ࡿࠋࡲࡓ⪏ᨺᑕ⥺࡟ࡶඃࢀࠊ
ศ๭ࡋ࡚⤌ࡳྜࢃࡏࠊᵓ㐀ᮦࠊ౛࠼ࡤ࣑࣮ࣛ⮬యࢆ┿✵ࢳࣕࣥࣂ࣮ࡸ㐽ⶸ࡜ࡋ࡚ࡶ࡞࡝฼⏝࡛ࡁࠊ௒ࡲ
࡛ࡢప㏿୰ᛶᏊ㍺㏦ࢆ᰿ᮏⓗ࡟ኚ࠼ࡽࢀࡿྍ⬟ᛶࡀ࠶ࡿࠋᡃࠎࡣ↓㟁ゎࢽࢵࢣ࣓ࣝࢵ࢟ࢆ⏝࠸ࡿࡇ࡜࡛
⾲㠃⢒ࡉ 0.3nm ௨ୗࢆᐇ⌧ࡋࠊJ-PARC BL16(SOFIA)཯ᑕ⋡ィ࡛ࡶᐇ⏝ྍ⬟࡞ 1 ḟඖᴃ෇ࢫ࣮ࣃ࣮࣑࣮ࣛ
ࡢ㛤Ⓨ࡟ᡂຌࡋࡓ[2]ࠋ
ࡉࡽ࡟௒ᅇࠊୡ⏺࡛ึࡵ࡚㔠ᒓᇶᯈࡢᅇ㌿ᴃ෇య୰ᛶᏊࢫ࣮ࣃ࣮࣑࣮ࣛࡢ㛤Ⓨ࡟ᡂຌࡋࠊBL06 ࣅ࣮࣒ࣛ࢖࡛ࣥࠊ࣋࣊ࣥ㓟㖟ࡢ୰ᛶᏊᑠゅᩓ஘ࡢ᫂░࡞ࣆ
࣮ࢡࡢほ ࡟ᡂຌࡋࡓࠋᙜ᪥ࡣࠊࡇࡢᑠゅᩓ஘ᐇ㦂ࡢ⤖ᯝ࡜㞟ග࣑࣮ࣛ㛤ⓎࠊMIEZE ศගჾࡢ⌧≧➼ࠊ
VIN ROSE 㛤Ⓨࡢ⌧≧ࢆ㏙࡭ࡿࠋ
ͤJST ග࣭㔞Ꮚ⼥ྜ㐃ᦠ◊✲㛤Ⓨࣉࣟࢢ࣒ࣛࢆ୰ᚰ
࡟ࠊ㔠ᒓᇶᯈࡢ୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨᕤ⛬ࡀ☜❧ࡋࡘࡘ࠶ࡿࠋࡲࡓி኱⅔ࡢᕤసᲷ࡟2014ᖺ2᭶࡟ᑟධ
ࡋࡓ୰ᛶᏊගᏛ⣲Ꮚ἞ල〇స⏝NC ไᚚຍᕤ⿦⨨࡛ึᮇຍᕤࡸᡂ⭷἞ලࢆ〇సࡋ࡚࠸ࡿࠋ㉸⢭ᐦຍᕤࡢᑓ㛛ᐙ࡜ඹྠ◊✲ࡍࡿࡇ࡜࡛ࠊி኱⅔࡟࠾ࡅࡿ⢭ᐦຍᕤᢏ⾡ࡣ኱ኚ㐍Ṍࡋࡓࠋࡇࡢヲ⣽ࡣྜྷỌ௚ࡢⓎ⾲ࢆཧ↷ࡉࢀࡓ࠸ࠋ
[1] T.Oda, M.Hino, M.Kitaguchi, P.Geltenbort,
Y.Kawabata, Rev. Sci. Instrum. 87(2016) 105124.
[2]S.Takeda, Y.Yamagata, N.L.Yamada, M.Hino,
T.Hosobata, J.Guo, S.Morita, T.Oda, M.Furusaka,
OpticsExpress, 24(2016) 12478.

Current status of development of VIN ROSE and neutron focusing mirrors II
Masahiro Hino, Tatsuro Oda, Hisao Yoshinaga, Masaya Kanayama, Yuji Kawabata, Hitoshi Endo, Norifumi Yamada, Takuya Hosobata, Shin Takeda, Guo Jiang, Yutaka Yamagata, Michihiro Furusaka, Shin-ya Morita, Hiseki Seto
hino@rri.kyoto-u.ac.jp

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㻔㻼㻝㻜㻕 KUR-IBS ࢆ⏝࠸ࡓ◊✲ᒎ㛤
ி኱⅔ ‫ۑ‬᪥㔝ṇ⿱ࠊᑠ⏣㐩㑻ࠊ㊊❧ᮃࠊ኱ሙὒḟ㑻ࠊྜྷỌᑦ⏕ࠊᮡᒣṇ᫂ࠊᕝ➃♸ྖᖹᆒᵓ㐀࡜ࡋ࡚ࡢἜ⭷ᵓ㐀ࡢ᥈⣴ཬࡧ KUR-IBS ࡟ࡼࡿࣔࢹࣝⷧ⭷ࡢస〇࡟ᣮᡓࡋ࡚࠸ࡿ[6]ࠋ

‫࡟ࡵࡌࡣۑ‬ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤ㸦ி኱⅔㸧ࡣࠊୡ⏺᭷ᩘࡢ୰ᛶᏊ཯ᑕගᏛ⣲Ꮚ㛤ⓎᣐⅬ࡛࠶ࡿࠋ᪥ᮏึࡢ୰ᛶᏊ
ᑟ⟶(E-3)ࠊୡ⏺ึࡢᮏ᱁ⓗ࡞ࢫ࣮ࣃ࣮࣑࣮ࣛᑟ⟶(B-4)➼ࢆ࡚ࡀࡅ࡚ࡁࡓࠋࡇࢀࡽ࡛౑⏝ࡉࢀ࡚࠸ࡿࢫ
࣮ࣃ࣮࣑࣮ࣛࡣி኱⅔ෆ࡛ᡂ⭷ࡉࢀࡓࡶࡢ࡛࠶ࡿࠋ
ி኱⅔࡟࠾ࡅࡿከᒙ⭷࣑࣮ࣛᡂ⭷⿦⨨࡜ࡋ࡚ࡣࠊ
1986 ᖺ࡟ᑟධࡋࡓ኱㠃✚┿✵⵨╔⿦⨨࡜ 2002 ᖺ࡟ᑟධࡋࡓ࢖࢜ࣥࣅ࣮࣒ࢫࣃࢵࢱ⿦⨨(KUR-IBS)ࡢ 2ྎࡀ࠶ࡿࠋ⌧ᅾࡶ୰ᛶᏊ཯ᑕගᏛ⣲Ꮚ㛤ⓎᣐⅬ࡜ࡋ࡚ᡂࡾ❧ࡗ࡚࠸ࡿࡢࡣࠊKUR-IBS ࡢᐤ୚ࡀ኱ࡁ࠸ࠋKUR-IBSࡣ㧗ရ㉁࣭ᴟ༤ከᒙⷧ⭷ࢆ〇㐀ࡍࡿࡇ࡜ࡀ࡛ࡁࠊ
CN-2 ࡢ୰ᛶᏊᑠゅᩓ஘⿦⨨(KUMASANS)ࡢࣔࣀࢡ
࣓࣮ࣟࢱ᭦᪂࡟ࡼࡿ୰ᛶᏊᙉᗘࡢ୍᱆㏆࠸ቑຍ࡟ᡂ
ຌࡋ࡚࠸ࡿ㸦ᢞ✏ㄽᩥ‽ഛ୰㸧ࠋࡲࡓ JRR-3 ࡸ J-PARC➼࡛ࡶ୰ᛶᏊ࣑࣮ࣛࢆ࣮࢟ࢹࣂ࢖ࢫ࡜ࡋ࡚౪⤥ࠊ⿦⨨ࢆ〇సࡍࡿ࡜ඹ࡟ඹྠ฼⏝◊✲ࢆ᥎㐍ࡋ࡚࠸ࡿ[1,2]ࠋࡉࡽ࡟᭱㏆ࡣ⌮◊ࡸ KEK ➼࡜༠ຊࡍࡿࡇ࡜࡟
ࡼࡾ㔠ᒓᇶᯈࢆ⏝࠸ࡓ୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨࢆ⾜ࡗ࡚࠾ࡾࠊࡑࡢ〇సࣉࣟࢭࢫࢆ☜❧ࡋࡘࡘ࠶ࡿ[3,4]ࠋ
ࡇࡇ࡛㔠ᒓࢆᇶᯈ࡜ࡍࡿࡇ࡜࡛ࠊ⪏ᨺᑕ⥺࡟ࡶඃࢀࠊ
ศ๭ࡋ࡚⤌ࡳྜࢃࡏࠊᵓ㐀ᮦࠊ౛࠼ࡤ࣑࣮ࣛ⮬యࢆ┿✵ࢳࣕࣥࣂ࣮ࡸ㐽ⶸ࡜ࡋ࡚ࡶ฼⏝ྍ⬟࡜࡞ࡿࠋࡲ
ࡓᶵᲔຍᕤ⏝ࡢ NC ຍᕤᶵ࡛ࡢ〇సࡀྍ⬟࡜࡞ࡾࠊ๻ⓗ࡞〇సᮇ㛫▷⦰࡜ࢥࢫࢺ๐ῶࡶᮇᚅ࡛ࡁࡿ➼ࠊ௒ࡲ࡛ࡢప㏿୰ᛶᏊ㍺㏦ࢆ኱ࡁࡃኚ࠼ࡿྍ⬟ᛶࡀ࠶ࡿࠋ⪏ᨺᑕᛶࢆᐇ㦂ࡋࠊࡼࡾᗈࡃᒎ㛤ࡍࡿࡓࡵ࡟ࠊ
PSI-⌮◊-ி኱⅔࡛ MOU ⥾⤖ࡢ‽ഛࢆ㐍ࡵ࡚࠸ࡿࠋ
ࡇࡢࡼ࠺࡟୰ᛶᏊ࣑࣮ࣛ㛤Ⓨࡣ⌧ᅾࡶάἣ࡛࠶ࡿࡀࠊ
ࡑࢀ௨እࡢ฼⏝ࡶቑ࠼࡚ࡁࡓࡢ࡛ࠊࡑࡢ୍➃ࢆ௨ୗ
࡟㏙࡭ࡿࠋ‫ۑ‬୰ᛶᏊ཯ᑕ⋡࣭ᑠゅᩓ஘⏝ヨᩱస〇ྠᚿ♫኱ࡢᖹᒣ᭸ᏊẶࡽ࡜཯ᑕ⋡ἲ࡟ࡼࡿࢺࣛ࢖
࣎ࣟࢪ࣮⏺㠃ࡢᵓ㐀ゎᯒࢆ㐍ࡵ࡚࠾ࡾࠊ₶⁥Ἔ୰ࡢῧຍ๣ࡢ྾╔≧ែࡀ୰ᛶᏊ཯ᑕ⋡ἲ࡟ࡼࡗ࡚᫂ࡽ࠿
࡟࡞ࡗ࡚ࡁࡓ[5]ࠋࡑࡋ࡚ JST ⏘Ꮫඹ๰ᇶ♏ᇶ┙◊✲ࣉࣟࢢ࣒ࣛࠕ㗰ᮦ㸭₶⁥Ἔࠖ⏺㠃࡟࠾ࡅࡿᶵ⬟ᛶ࣊ࢸࣟࢼࣀᵓ㐀ไᚚ࡟ᇶ࡙ࡃ㌿ື⑂ປ㧗≉ᛶ໬ࡢࡓࡵ
ࡢᣦᑟཎ⌮ࡢ☜❧࡛ࠖࡣࠊ཯ᑕ⋡ἲࡔࡅ࡛࡞ࡃࠊMo⥺※ࡢ SAXSࠊKUMASANS ࢆ⏝࠸࡚ࠊX ⥺࣭୰ᛶᏊ⥺࡟࠾ࡅࡿ཯ᑕ⋡࣭ᑠゅᩓ஘ἲ࡟ࡼࡿᶵ⬟ᛶ⭷ࡢᖹᆒⓗᵓ㐀ホ౯ࢆ⾜ࡗ࡚࠸ࡿࠋࡇࢀࡣᮦᩱࡢ⤌⧊㸪≉࡟⤖ᬗ⢏⏺ࡸ㌿఩࡞࡝ࡢ᱁ᏊḞ㝗࡟ࡼࡗ࡚₶⁥Ἔ⭷ࡢᙧᡂ㸦ไᚚ㸧ࡀᐇ⌧ྍ⬟࡛ࡣ㸽࡜ࡢ᪂ࡋ࠸どⅬ࡛ࠊ‫ۑ‬୰ᛶᏊ᳨ฟჾ⏝ࢥࣥࣂ࣮ࢱ࣮㛤Ⓨ⏘⥲◊ࡢ⸨ཎ೺Ặࡸ KEK ࡢᒣ⏣ᝅྐࡽ࡜ࠊJST ග࣭㔞Ꮚ⼥ྜ㐃ᦠ◊✲㛤Ⓨࣉࣟࢢ࣒ࣛࡸ◊✲ᡂᯝ᭱㐺ᒎ㛤ᨭ᥼ࣉࣟࢢ࣒ࣛ(A-STEP)ࠕࢥࣥࣃࢡࢺ୰ᛶᏊ※࡜ࡑࡢ⏘ᴗᛂ⏝࡟ྥࡅࡓᇶ┙ᢏ⾡ࡢᵓ⠏ࠖࡢᨭ᥼ࢆᚓ
࡚ࠊ10B ࡸ 10B4C ࢆ⏝࠸ࡓ୰ᛶᏊࢥࣥࣂ࣮ࢱ࣮ࢆ㛤Ⓨ୰࡛࠶ࡿࠋࡇࢀࡣᡓ␎≀㉁࡜ࡋ࡚ᯤῬࡋ࡚࠸ࡿ He-3
࢞ࢫ᳨ฟჾ࡟௦ࢃࡿࠊศගჾ࡟฼⏝ྍ⬟࡞༶ᡓຊ࡜
࡞ࡿ୰ᛶᏊ᳨ฟჾࡢࢥࣥࣂ࣮ࢱ࣮㛤Ⓨࢆࡋ࡚࠸ࡿࠋ
ࡲࡓྡྂᒇ኱Ꮫࡢ㛗⦖┤ᓫẶࡽ࡜ᮍ▱▷㊥㞳ຊࡢ᥈⣴➼ࢆ┠ᣦࡋࡓ୰ᛶᏊࡢ(ᆅ⌫)㔜ຊࡢ㔞Ꮚᅛ᭷≧ែࡢ⢭ᐦ ᐃ[7,8]࡟ࡶ฼⏝࡛ࡁࡿࠊ✵㛫ศゎ⬟ 10nm ࢆࢱ࣮ࢤࢵࢺ࡜ࡋࡓ㉸㧗ศゎ⬟ࡢ㉸෭୰ᛶᏊ᳨ฟჾ㛤Ⓨࢆ⾜ࡗ࡚࠸ࡿࠋࡇࢀࡣཎᏊ᰾ங๣ࢆ⏝࠸ࡿࡶࡢ࡛ࠊ
ከᒙᵓ㐀➼࡟ࡍࡿࡇ࡜࡛ࠊ㛗ᮇ㛫ࡢࢥࣥࣂ࣮ࢱ࣮⭷ࡢᏳᐃᛶࢆ࡯ࡰ☜❧ࡋࡓࠋ௒ᚋி኱⅔ࡸ J-PARCࠊILL➼࡛ࡢᐇ㦂ࢆ㏻ࡌ࡚ᛶ⬟ࢆホ౯ࡋࠊ≀⌮ᐇ㦂࡟㐍ࡴࠋ‫ࡿ࡞ࡽࡉۑ‬ᒎ㛤ࢆ┠ᣦࡋ࡚ࡑࡢ௚ࠊILC (International Linear Collider㸧࡟࠾ࡅࡿ㧗࿘Ἴຍ㏿✵Ὕࡢࡓࡵࡢከᒙ⭷㉸ఏᑟⷧ⭷㛤Ⓨ࡟༠ຊࡋ࡚࠸ࡿࠋᵝࠎ࡞≀㉁ࢆᡂ⭷ࡍࡿࡓࡵ୙⣧≀ࡀΰධࡋࡸࡍ࠸⌧ᅾࡢ฼⏝య⣔࡛ࡣᐜ᫆࡞ࡇ࡜࡛ࡣ࡞࠸
ࡀࠊ኱㠃✚࡛ᆒ୍࡞ከᒙ⭷ࡀᚲせ࡞ࡇ࡜ࡀ࠶ࡾࠊ㞟ග࣑࣮ࣛࡢ▱ぢࡶά࠿ࡏࡿྍ⬟ᛶࡶ࠶ࡿࡢ࡛᪂ࡓ࡞
ྲྀࡾ⤌ࡳ࡜ࡋ࡚ᣮᡓࢆ㛤ጞࡋ࡚࠸ࡿࠋ
KUR-IBS ࡣᑟධ࠿ࡽ 15 ᖺ࡜࡞ࡿࡀࠊ୰ᛶᏊ࣑ࣛ
࣮㛤Ⓨ࡜ࡋ࡚⌧ᙺ࡛࠶ࡿࡔࡅ࡛࡞ࡃࠊ㸦⥔ᣢࡍࡿࡓࡵ࡟ࡶ㸧ᵝࠎ࡞ᒎ㛤ࢆ✚ᴟⓗ࡟⾜ࡗ࡚࠸ࡿࠋ௒ᚋࡶ
ᵝࠎ࡞ᒎ㛤ࢆ⾜࠺࡜ඹ࡟ࡋࡗ࠿ࡾ⥔ᣢࢆࡋ࡚ࠊி኱
⅔ࡢᑗ᮶ィ⏬ࠕ」ྜཎᏊຊ⛉Ꮫࡢ᭷ຠ฼⏝࡟ྥࡅࡓඛᑟⓗ◊✲ࡢ᥎㐍ࠖ࡟࠾ࡅࡿప㏿୰ᛶᏊࣅ࣮࣒฼⏝᪋タᐇ⌧࡟㈉⊩ࡋ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ
[1]᪥㔝ṇ⿱ ᨺᑕ⥺ 41(2015)27.
[2] S.Imajo, et al.,PTEP(2016), 013C02[3] S.Takeda, et al., Optics Express, 24(2016) 12478.
[4] ྜྷỌᑦ⏕ ௚ࠊᮏᏛ⾡ㅮ₇఍ሗᩥ㞟[5] T.Hirayama, et al., Tribol. Int. 54 (2012) 100.
[6] ㊊❧ᮃ ௚ࠊᮏᏛ⾡ㅮ₇఍ሗᩥ㞟
[7] V. Nesvizhevsky, et al., Nature 415 (2002) 297.
[8] G.Ichikawa, et al., Phys.Rev.Lett. 112(2014) 071101.

Activity of research and development of the KUR-IBS
Masahiro Hino, Tatsuro Oda, Nozomu Adachi, Yojiro Oba, Hisao Yoshinaga, Masaaki Sugiyama, Yuji Kawabata
hino@rri.kyoto-u.ac.jp

㻙 㻞㻠㻌㻙

㻔㻼㻝㻝㻕 ໟ᥋໬ྜ≀ࢆ฼⏝ࡋࡓぶỈᛶ㧗ศᏊ࡜㔠ᒓሷ࡜ࡢࢥ࣏ࣥࢪࢵࢺࡢస〇 >9@㹼␯Ỉᛶ⾲㠃ࡢᨵ㉁㹼
㸦ி኱ཎᏊ⅔㸧‫ۑ‬ᕝཱྀ᫛ኵ㸯㸬ࡣࡌࡵ࡟㸸ぶỈᛶ㧗ศᏊ࡜ࣚ࢘⣲㸦࣏ࣜࣚ࢘⣲࢖࢜ࣥࠊ,n㸧࡜ࡢᵓ㐀ᙧᡂ࡜ࡋ࡚᭱ࡶࡼࡃ▱ࡽࢀ࡚࠸ࡿࡢࡣࠕࣚ࢘⣲㸫ࢹࣥࣉࣥ཯ᛂ࡛ࠖ࠶ࡿࠋࡇࢀࡣ
Ỉ⁐ᛶࡢぶỈᛶ㧗ศᏊ࡛࠶ࡿ࢔࣑࣮ࣟࢫ࡜࣏ࣜࣚ࢘
⣲࢖࢜ࣥ㸦௨ୗࠊࠕࣚ࢘⣲ࠖ࡜␎㸧࡜ࡢỈ⁐ᾮ୰࡛ࡢໟ᥋ᵓ㐀㸦ࢥࣥࣉࣞࢵࢡࢫ㸧ᙧᡂ࡛࠶ࡾࠊỈ࿴࡟క࠺ศᏊ㙐ࡢ㐠ືᛶ࣭㧗⮬⏤ᗘࢆ⫼ᬒ࡜ࡋ࡚࠸ࡿࠋࡑ
ࡇ࡛ࡢࣚ࢘⣲✀㸦, ࡢᏑᅾ㸧ࡸໟ᥋ᙧ≧㸦࢔࣑࣮ࣟࢫ㙐␯Ỉ㒊࡜ࣚ࢘⣲࡜ࡢࡽࡏࢇ≧ໟ᥋㸽㸧ࡣࠕᐃㄝࠖ
࡜ࡋ࡚ࡢㄝ᫂ࡀ࠶ࡿ୍᪉࡛ࠊ௒࡛ࡶ␲⩏ࡸ᪂ゎ㔘ࡶᥦၐࡉࢀ࡚࠸ࡿࠋ>@ࡑࡋ࡚㠀Ỉ⁐ᛶ࡛ぶỈᛶࡢ࣏ࣜࣅࢽࣝ࢔ࣝࢥ࣮ࣝ
39$ ࡸ࣏ࣜ࢔࣑ࢻ㸴 3$ ࡞࡝ࡶࠊᕧどⓗᙧ≧ࢆ⥔ᣢࡋࡓࡲࡲ࡛ࣚ࢘⣲㸦࡜࢝࢘ࣥࢱ࣮࢖࢜ࣥ㸧ࢆྲྀࡾ㎸ࡳࠊᐊ ୗ࡛࢖࢜ࣥ⛣ືࡸᵓ㐀㌿᥮ࢆάᛶ໬ࡉࡏ
ࡿࠋ>@ ࡇࢀࢆᛂ⏝ࡍࡿࡇ࡜࡛ࠕᙧ≧ࡸศᏊ㙐㓄ྥࢆ⥔ᣢࡋࡓࡲࡲࡢ࢖࢜ࣥᣑᩓࠖ
ࠕ㸦ෆ㒊✵㛫࡛ࡢሷᯒฟ
࡟ࡼࡾ㸧࣐ࢺࣜࢡࢫࡢྜᡂ࣭⁐⼥࣭⁐ゎࡸࣇ࢕࣮ࣛΰ⦎ࢆᚲせ࡜ࡋ࡞࠸ࣁ࢖ࣈࣜࢵࢻࢥ࣏ࣥࢪࢵࢺ໬ࠖ
ࡀྍ⬟࡛࠶ࡿࡇ࡜ࢆࠊࡇࢀࡲ࡛࡟♧ࡋ࡚ࡁࡓࠋ>@ࡋ࠿ࡋ࢔࣑࣮ࣟࢫࢹࣥࣉ࡛ࣥࡢࢥࣥࣉࣞࢵࢡࢫᙧᡂ
ࡶྵࡵ࡚ࠊヨᩱㄪ〇ࡸ཯ᛂ☜ㄆࡣᐜ࡛᫆࠶ࡿ࡟ࡶ࠿
࠿ࢃࡽࡎࠊ࣑ࢡࣟ࡞ᵓ㐀ࡸ཯ᛂࢆỴᐃ࡙ࡅࡿࡇ࡜ࡣ
ண᝿௨ୖ࡟ᅔ㞴࡛࠶ࡿࠋࡑࢀࡣ࣏ࣜࣚ࢘⣲࢖࢜ࣥࡀࠊ
ศᏊୖ࡟㟁Ⲵࢆᣢࡕ࡞ࡀࡽࡑࡢ㟁Ⲵࢆᐜ᫆࡟೫ᅾࡉ
ࡏࡿࡔࡅ࡛࡞ࡃࠊཎᏊ஺᥮ࡸ෌⤖ྜ࡟ࡼࡗ࡚ศᏊ࡜
ࡋ࡚㸦ᰂ㌾࡟㸧ᵓ㐀ࡀኚ໬ࡍࡿࡓࡵ࡛࠶ࡿࠋ
ࡇࡢࡼ࠺࡞ࠕᵓ㐀୙☜ᐃᛶࠖࠕືⓗᰂ㌾ᛶࠖࡣỈ⁐ᾮ࡞࡝ࡢ➼᪉ⓗ⁐፹⎔ቃࡼࡾࡶぶỈᛶ࣐ࢺࣜࢡࢫ࡟࠾
࠸࡚ࡼࡾ㢧ⴭ࡜࡞ࡿࠋ⤖ᯝⓗ࡟໬Ꮫ⤌ᡂ㸦㸯ḟᵓ㐀㸧࡟ࡼࡿᵓ㐀࣭ᣲືࡢไᚚࡀ㞴ࡋࡃ࡞ࡿࡀࠊ
ࠕỗ⏝ᛶᶞ⬡࡬ࡢᚋຍᕤࠖ
ࠕᡂᆺᚋࡢᶵ⬟ᛶ௜୚ࠖ࡟ࡣࡑࢀࢆୖ
ᅇࡿ࣓ࣜࢵࢺࡀ࠶ࡿࠋ௒ᅇࡢሗ࿌ࡣࡑࢀࢆᛂ⏝ࡋࡓࠗ␯Ỉᛶ࣐ࢺࣜࢡࢫ࡬ࡢࠊỈ⁐ᾮ࠿ࡽࡢ࢖࢜ࣥᣑᩓ࠘
ࢆ฼⏝ࡋࡓ↓㟁ゎ࣓ࢵ࢟࡟ࡘ࠸࡚ሗ࿌ࡍࡿࠋ>@㸰㸬ᐇ㦂㸸␯Ỉᛶ࣐ࢺࣜࢡࢫ࡜ࡋ࡚ࢩࣜࢥࣥࢦ࣒ࢳ
࣮ࣗࣈࠊ࣏ࣜࣉࣟࣆࣞࣥ 33 ࣇ࢕࣒ࣝࠊ࣏࢚ࣜࢳࣞ
ࣥࢳ࣮ࣗࣈࠊ㸦࣏ࣜࢫࢳࣞࣥࢆ⾲㠃ࢢࣛࣇࢺ໬ࡋࡓ㸧␯Ỉᛶ࢔ࢡࣜࣝᚤ⢏Ꮚ࡞࡝ࢆ⏝࠸ࡓࠋࡇࢀࡽࡢ࣐ࢺ
ࣜࢡࢫ࡟ᑐࡋ࡚ࠊ࣏ࣜࣚ࢘⣲࢖࢜ࣥࢆྵࡴỈ⁐ᾮ ,., DT  1 HWF ࡟ࡼࡿࠕࣚ࢘⣲㸦㸯ḟ㸧ࢻ࣮ࣉࠖࠊ$J ࢖࢜ࣥࡢࠕ㸰ḟࢻ࣮ࣉࠖ࡞࡝ࡢฎ⌮ࢆ᪋ࡋࡓᚋ࡟ࠊ↓㟁ゎ࣓ࢵ࢟ฎ⌮㸦ୖᮧᕤᴗࠕࢫࣝ࢝
ࢵࣉ 36<ࠖ㸧࡟ࡼࡗ࡚ྛ࣐ࢺࣜࢡࢫ⾲㠃࡬ࡢ &X ࣓ࢵ࢟⓶⭷ᙧᡂࢆヨࡳࡓࠋ㸦඲࡚ࡢฎ⌮ࡣaGHJ࡛ᐇ᪋㸧㸱㸬⤖ᯝ㸸௒ᅇ⏝࠸ࡓ඲࡚ࡢ␯Ỉᛶ࣐ࢺࣜࢡࢫ࡛ࠊ
ࠕࣚ࢘⣲ࢻ࣮ࣉࠖฎ⌮ᚋࡢࣚ࢘⣲ỿ╔࡟ࡼࡿ╔Ⰽ࡜ࡑࡢᚋࡢࠕ㸰ḟࢻ࣮ࣉࠖࡸ㑏ඖฎ⌮࡟క࠺ሷᯒฟࡸ
⬺Ⰽࡀㄆࡵࡽࢀࡓࠋࡓࡔࡋඖࡢ QRQGRSHG ࣐ࢺࣜࢡࢫ࡟ᑐࡍࡿ㉁㔞ቑ 'm ࡣࠊࠕࣚ࢘⣲ࢻ࣮ࣉࠖẁ㝵࡛ぶỈᛶ࣐ࢺࣜࢡࢫ࡛ࡣ'ma࡛࠶ࡿࡢ࡟ᑐࡋ࡚ࠊ
␯Ỉᛶ࣐ࢺࣜࢡࢫ࡛ࡣ࡯ࡰ 'm⛬ᗘ࡜ᚤ㔞࡛࠶ࡾࠊ࣐ࣛࣥศගἲ࡟ࡼࡿᵓ㐀ゎᯒ࡞࡝࡛ഹ࠿࡟࣏ࣜ
ࣚ࢘⣲࢖࢜ࣥࡢᏑᅾࡀ☜ㄆ࡛ࡁࡿ⛬ᗘ࡛࠶ࡿࠋ>@ࡑࡋ࡚ QRQGRSHG ࡲࡓࡣࠕࣚ࢘⣲ࢻ࣮ࣉࠖࡋࡓ࣐ࢺ
ࣜࢡࢫ࡟ࡣ↓㟁ゎ㖡࣓ࢵ࢟ࡀ࡯࡜ࢇ࡝㐍⾜ࡋ࡞࠸ࡀࠊ
ࠕ㸰ḟࢻ࣮ࣉࠖࡲ࡛ࢆ᪋ࡋࡓ࣐ࢺࣜࢡࢫࡢᑐࡋ࡚ࡣ
↓㟁ゎ㖡࣓ࢵ࢟㸦࣐ࢺࣜࢡࢫ⾲㠃࡛ࡢ &X ⓶⭷ᙧᡂ㸧ࡀ㐍⾜ࡋࡓࠋࡇࢀࡣ⾲㠃㏆ഐࡢ↓ᶵሷࡀ &X ᯒฟࡢึᮇ᰾࡜ࡋ࡚ᶵ⬟ࡋ࡚࠸ࡿࡶࡢ࡜ゎ㔘࡛ࡁࡿࠋࡘࡲࡾ␯Ỉᛶ࣐ࢺࣜࢡࢫ࡛ࡢࣚ࢘⣲ࡢ྾⬺╔ࡣ㸦࡯ࡰ㸧࣐ࢺࣜࢡࢫࡢ⾲㠃ᒙ࡛ࡢ⛣ື࣭ᣑᩓ࡜⪃࠼ࡽࢀࡿ୍᪉࡛ࠊ୍㒊࡟ࡣẚ㍑ⓗ࡟῝㒊࡟ࡲ࡛ࣚ࢘⣲ࡸ࢖࢜ࣥࡢᣑᩓ࣭ṧ␃ࡀ㐍⾜ࡍࡿ⣔ࡶᏑᅾࡍࡿࠋࡓࡔࡋ
ࠕ⾲㠃࡛ࡢ↓㟁ゎ࣓ࢵ࢟ࠖࢆ┠ⓗ࡜ࡍࡿሙྜ࡟ࡣ῝㒊ࡲ࡛ࡢ࢖࢜ࣥᣑᩓࡸෆ㒊ᯒฟ≀ࡀᚲࡎࡋࡶ⾲㠃࡛ࡢᯒฟ࡟᭷ຠ࡟ᶵ⬟ࡏࡎࠊෆ㒊࡟ṧ␃ࡋࡓᮍ཯ᛂࡢ
ࣚ࢘⣲ࡢ෌ᨺฟࡀ㑏ඖ཯ᛂࢆ㜼ᐖࡍࡿྍ⬟ᛶࡶ࠶ࡿࡢ࡛ᮃࡲࡋࡃ࡞࠸ࡇ࡜࡟࡞ࡿࠋ
ࡇࡢࡼ࠺࡟ࠕ␯Ỉᛶ࣐ࠖࢺࣜࢡࢫ࡛࠶ࡗ࡚ࡶỈ⁐ᾮ࠿ࡽࡢ࢖࢜ࣥᣑᩓࡸෆ㒊཯ᛂ࡟ࡼࡿሷᯒฟࡀ㐍⾜ࡍࡿ⌮⏤࡜ࡋ࡚ࠊ㧗ศᏊ⣔࣐ࢺࣜࢡࢫࡀ㧗ḟᵓ㐀࡟⏤᮶ࡍࡿࠊ₯ᅾⓗ࡞ᴟᛶࢆᣢࡘࡇ࡜ࡀ⪃࠼ࡽࢀࡿࠋࡑ
ࡇ࡛ࡣ໬Ꮫ⤌ᡂ㸦㸯ḟᵓ㐀㸧ୖࡣぶỈᛶࡸ㟁Ⲵᵓ㐀ࢆᣢࡓ࡞࠸࣐ࢺࣜࢡࢫ࡛࠶ࡗ࡚ࡶࠊࣚ࢘⣲ࢆ฼⏝ࡍࡿࡇ࡜࡛Ỉ⁐ᾮ࠿ࡽࡢ࢖࢜ࣥᣑᩓࡀ㐍⾜ࡍࡿࠋ࡞࠾ᮏ◊✲ࡢ୍㒊ࡣࠕᖹᡂ  ᖺᗘ ᪂࢚ࢿࣝࢠ࣮࣭
⏘ᴗᢏ⾡⥲ྜ㛤Ⓨᶵᵓ 1('2 ࢖ࣀ࣮࣋ࢩࣙࣥᐇ⏝໬ຓᡂ஦ᴗࠖࡢຓᡂࡢඖ࡛⾜ࢃࢀࡓࠋཧ⪃ᩥ⊩>@ 566WHLQ 5(5XQGOH-&KHP3K\V  
>@ $.DZDJXFKLSens. and Act. B   
>@ ᕝཱྀ ௚ࠊ㧗ศᏊᏛ఍ண✏㞟 
>@ ᕝཱྀࠊ᪥ᮏ໬Ꮫ఍➨ 95 ᫓Ꮨᖺ఍ㅮ₇ண✏㞟  $ >@ ᕝཱྀࠊ᪥ᮏ໬Ꮫ఍➨ 93 ᫓Ꮨᖺ఍ㅮ₇ண✏㞟  & >@ ᕝཱྀࠊ㧗ศᏊᏛ఍ண✏㞟   

6WUXFWXUHDQG8WLOL]DWLRQRI3RO\LRGLGH&RRUGLQDWHGZLWKLQK\GURSKLOLF3RO\PHUVIRU0HWDO6DOWV&RPSRVLWHV>9@
6XUIDFH0RGLILFDWLRQRI³+\GURSKRELF´0DWUL[$NLR.DZDJXFKL 
DNDZDJFK#UULN\RWRXDFMS㻙 㻞㻡㻌㻙

㻔㻼㻝㻞㻕 ᐆ▼ホ౯࡟ྥࡅࡓගᏛⓗ㛫᥋ᢞᙳἲ㸦ி኱ཎᏊ⅔ࠊ஧ᐑᐆ▼ ᰴ 㸧‫ۑ‬ᕝཱྀ᫛ኵࠊ஧ᐑὒᩥ 㸯㸬ࡣࡌࡵ࡟㸸ኳ↛㖔≀ࢆேᕤⓗ࡟◊☻ຍᕤ㸦࢝ࢵࢺ㸧ࡍࡿࡇ࡜࡟ࡼࡗ࡚ၟရ౯್ࢆᚓࡿࠕᐆ▼ࠖ࡟ࡣࠊࡑࡢホ౯ಖド࡜ࡋ࡚໬Ꮫⓗ࡞ᡂศ⾲♧ࢆ♧ࡍࠕ㚷ู
᭩ࠖ࡜どぬⓗホ౯࡟ᇶ࡙ࡃࠕ㚷ᐃ᭩ࠖࡀῧ௜ࡉࢀࡿ
ࡇ࡜ࡀ࠶ࡿࠋ≉࡟ࠕ㚷ᐃ᭩ࠖࡀῧ௜ࡉࢀࡿࡢࡣ࢝ࢵ
ࢺࡉࢀࡓࢲ࢖ࣖࣔࣥࢻ㸦〄▼ࠊ࣮ࣝࢫ㸧ࡔࡅࡔࡀࠊ
⏘ฟࡢᕼᑡᛶࠊ㧗◳ᗘ༢⤖ᬗ࡜ࡋ࡚ࡢ㞴ຍᕤᛶࠊᚤ
㔞ඖ⣲ྵ᭷࡟క࠺╔Ⰽࠊෆໟ≀㸦ࢡࣛࢵࢡࠊ࢖ࣥࢡ
࣮ࣝࢪࣙࣥ㸧࡟ࡼࡿගࡢᨐ஘ࠊ࡞࡝ࡀ᭱⤊〇ရࡢ౯᱁ࢆ኱ࡁࡃᕥྑࡍࡿࡇ࡜࠿ࡽࠊࠕேᕤ㸦ྜᡂ㸧YV ኳ↛ࠖࡢุูࢆ┠ⓗ࡜ࡍࡿ௨እ࡟ࡣࠊ㚷ᐃホ౯࡟࠾ࡅࡿ⤌ᡂศᯒࡢ㔜せᛶࡣࠊ࠶ࡲࡾ㧗ࡃ࡞࠸ࠋ>@ࡑࡢ୍᪉࡛& &DUDW&RORU&ODULW\&XW ࡀࠕ㚷ᐃࠖࡢࡓࡵࡢホ౯ᇶ‽࡜ࡋ࡚ྲྀࡾୖࡆࡽࢀࡿࡇ࡜ࡀ࠶ࡿࠋ
ࡋ࠿ࡋࡇࢀࡽ࡟ࡘ࠸࡚ࡶࠊ࣮ࣝࢫ㉁㔞 &DUDW FW 
J ࡀ᭱ࡶᐈほⓗ࡞ ᐃ㔞࡛ࡣ࠶ࡿࡀࠊ
ࠕయ✚ࠖࡣᕼ
ᑡᛶࡢ┠Ᏻ࡛࠶ࡗ࡚ࡶ࢝ࢵࢺຍᕤᚋࡢホ౯࡜ࡣ┤᥋࡟㛵㐃ࡋ࡞࠸ࠋ&RORU㸦ࠕ㯤࿡ࠖࡢᙉࡉࠋ'a=㸧ࡣࠊ ྾཰ࢫ࣌ ࢡࢺࣝ࡟ ࡼࡗ࡚ಖ ドࡉࢀࡿ ୍᪉ ࡛
SLQNEOXH ࡞࡝ࡢ௜ຍ౯್ࡶ࠶ࡿࠋ&ODULW\ࡢࣛࣥࢡ)ODZOHVVa6 ࡶ㏱㐣ࢫ࣌ࢡࢺࣝ࡜㛵㐃࡙ࡅࡽࢀࡿࡀ &RORU ࡸ࢖ࣥࢡ࣮ࣝࢪࣙࣥ࡞࡝࡟ࡼࡿᨐ஘ࡀ࠶
ࡿࡓࡵ࡟ࠊࡇࢀࡶᐃ㔞ホ౯ࡣᐜ࡛᫆ࡣ࡞࠸ࠋ
ࡑࡋ࡚࢝ࢵࢺࢲ࢖ࣖࣔࣥࢻࡢどぬ༳㇟࡜ࡋ࡚᭱ࡶ
ッồຊࡢ࠶ࡿ≉ᚩࡣࠕ㍤ࡁࠖࠊࡘࡲࡾ◊☻㠃㸦ࣇ࢓ࢭࢵࢺ㸧࡛ࡢ཯ᑕග࡛࠶ࡾࠊࡑࢀࡣ&ࡢ࠺ࡕࡢ&XWࢢ࣮ࣞࢻ࡟ࡼࡗ࡚࡯ࡰỴᐃ࡙ࡅࡽࢀࡿࠋྠ᫬࡟ࠊே
Ⅽⓗຍᕤไᚚ㸦ࣉ࣏࣮ࣟࢩࣙࣥタィࠊ◊☻⢭ᗘࠊຍᕤ⇍⦎ᗘࠊᬗⒷ࡟ࡼࡿຍᕤ㞴᫆ᗘࡢᕪࠊ࡞࡝㸧ࡀࠊ᭱ࡶࠊ࠿ࡘ၏୍ࠊཬࡪࡢࡀ&XW࡛ࡶ࠶ࡿࡀࠊどぬ༳㇟࡬ࡢຠᯝࡶྵࡵ࡚ࠊࡑࡢ⛉Ꮫⓗ㸦ගᏛⓗ㸧᰿ᣐࡸᐈほⓗホ౯ἲࡀ☜❧ࡉࢀ࡚࠸ࡿ࡜ࡣゝ࠸ࡀࡓ࠸ࠋࡑ
ࢀ࡟ࡶ㛵ࢃࡽࡎࠊ᭱ࡶᮎ➃౯᱁࡟ᙳ㡪ࡍࡿホ౯ᇶ‽࡛࠶ࡾࠊࡲࡓྂ඾ⓗ࡞ගᏛཎ⌮࡟ࡼࡿどぬస⏝࡛࠶ࡿࡣࡎࡔࡀࠊ
ࠕ࢝ࢵࢺࢲ࢖ࣖࣔࣥࢻࡢ㚷ᐃホ౯ࠖࡢ୺ὶࡀࠕ㚷ᐃኈࠖࡢ⫗║࡟ࡼࡿᐁ⬟ホ౯࡟ጤࡡࡽࢀ࡚
࠸ࡿࡓࡵࠊホ౯⤖ᯝ࡟ࡣྜ⌮ᛶࡸ෌⌧ᛶࡀஈࡋ࠸ࠋ
➹⪅ࡽࡣ ᐃᑐ㇟࡜ࡋ࡚ࡢᐆ▼ヨᩱࡀࠊࣇ࢓ࢭࢵࢺ
࠿ࡽᵓᡂࡉࢀࡿከ㠃య࡛࠶ࡿ≧ἣ࡟ࡲࡎ╔┠ࡋࡓࠋᐇ㝿ࡢ㚷ᐃホ౯࡛ࡣࠕ➼᪉ⓗග※⎔ቃୗ࡟⨨࠿ࢀࡓ࢝ࢵࢺࢲ࢖ࣖࣔࣥࢻࢆࠊࠗࢸ࣮ࣈࣝ㠃࠘᪉ྥ࠿ࡽほᐹࡍࡿࠖ࡜࠸࠺ᡭἲࡀ᥇⏝ࡉࢀࡿࠋࡑࡇ࡛ᩓ஘≧ἣࢆᩘ್໬ࡍࡿࡓࡵ࡟ࠊᅇᢡἲࢆᛂ⏝ࡋࡓィ ᡭἲ࡟ࡼࡗ࡚ࢩ࣑࣮ࣗࣞࢺࡋࠊᩓ஘ගศᕸ㸦Ⓨᩓゅࡢ⤫ィศᕸࠊ᪉఩ゎᯒ࡞࡝㸧ࢆᩘ್໬ࡋࡓࠋ>@㸰㸬ᐇ㦂㸸ᨺ≀㠃ࢫࢡ࣮ࣜࣥࡢ↔Ⅼ఩⨨࡟⨨࠸ࡓᐆ▼ヨᩱ࡟ᑐࡋ࡚ࠊࢫࢡ࣮ࣜࣥࡢ୍㒊࡟タࡅࡓࢫࣜࢵ
ࢺ࠿ࡽヨᩱ┤ᚄࢆ࢝ࣂ࣮ࡍࡿࣅ࣮࣒ࢧ࢖ࢬࡢ┤㐍ࣞ,QGLUHFW3URMHFWLRQ 0HWKRGIRU2SWLFDO(VWLPDWLRQRI-HZHOV$NLR.DZDJXFKL+LURIXPL1LQRPL\DDNDZDJFK#UULN\RWRXDFMS㻙 㻞㻢㻌㻙

࣮ࢨ࣮ග㸦୍㒊࡛ᖹ⾜ᛶࡢⰋ࠸ⓑⰍ /(' ග㸧ࢆධᑕࡋࡓࠋࡇࡢ㝿࡟⏕ࡌࡿᩓ஘ගࢆᨺ≀㠃ࢫࢡ࣮ࣜࣥ࡟
ᢞᙳࡋࠊ༑ศ࡞㊥㞳ࢆ⨨࠸࡚ᨺ≀㠃㍈ୖ࡟タᐃࡋࡓ࣓࢝ࣛ࡟ࡼࡗ࡚᧜ീࡋࡓࠋ
㸱㸬⤖ᯝ㸸≉࡟࢝ࢵࢺࡉࢀࡓࢲ࢖ࣖࣔࣥࢻࡣ࡯ࡰ༢
⤖ᬗ࡜⪃࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࡢ࡛ࠊගࡢ┤㐍ᛶ࠿ࡽࠊග㊰ࡢኚ໬ࡣࠕࣇ࢓ࢭࢵࢺ㸦ෆ㸧㠃࡛ࡢ཯ᑕࠖ࡜ࠕヨᩱ⾲㠃࡛ࡢᒅᢡࠖࡔࡅࡀ⪃៖ࡉࢀࡿࠋࡘࡲࡾከ㠃య࡟ࡼࡿᩓ஘㸦ࣇ࢓ࢭࢵࢺ࡟࠾ࡅࡿヨᩱෆእ㠃࡛ࡢ཯ᑕ࣭ᒅᢡ㸧ࡣࠕ┤㐍ගࡢ㸦ࠕ⛸ࠖ࡟ࡼࡿ㸧ග㊰ศ๭ࠖ࡟⨨ࡁ᥮࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࠋ >@⤖ᯝⓗ࡟ග㏱㐣ᛶࡢⰋ࠸ከ㠃యヨᩱ࡟ᑐࡋ࡚ࠊ༑ศ
࡞ࣅ࣮࣒ᖜࢆᣢࡗࡓ┤㐍ගࢆධᑕࡉࡏࡓ࡜ࡁ࡟ࠕ㸦࡯ࡰ㸧┤㐍ගࠖ࡜ࡋ࡚ࡢගᩓ஘ࡀ⏕ࡌࡿග㊰ࡇࡑࡀᐇ㝿ࡢᐆ▼ヨᩱࡢࠕ㍤ࡁࠖࡢග㊰᮲௳࡜࡞ࡿࠋ୍⯡ⓗ࡞㚷ᐃ᪉ἲ࡟࠾ࡅࡿ᳨ฟ㔝ࡣࠕ㸦࠾࠾ࡼࡑࢸ࣮ࣈࣝ㠃᪉ྥ࡟࠶ࡿ㸧㚷ᐃኈࡢど㔝ࠖ࡞ࡢ࡛ࠊᩓ஘ග᮰ࡀࡑ
ࡢ᳨ฟ㔝㸦ᨺ≀㠃ࢫࢡ࣮ࣜࣥࡢ㡬Ⅼ௜㏆㸧ࢆ㉮ᰝࡍࡿࡇ࡜ࡀࠕ㍤ࡁࠖࡢㄆ㆑ࡢ᮲௳࡜࡞ࡿࠋ
௒ᅇࡣࠕ➼᪉ⓗග※ࠖࢆ㏆ఝࡍࡿࡼ࠺࡟ධᑕග᪉఩
ࢆከࡃྲྀࡾ࡞ࡀࡽࠊྛ᪉఩ࡢ㸦┤㐍㸧ධᑕග࡟ࡼࡗ
࡚⏕ࡌࡿࠕ㍤Ⅼࠖ㸦ศ๭ࡉࢀࡓ⤖ᯝ࡜ࡋ࡚ࡢᩓ஘ග㸧࡟ࡘ࠸࡚❧యゅ : ศᕸࢆࠊୖ༙⌫ࡢ⠊ᅖ S ࡟ᑐࡋ࡚⏬ീゎᯒ࠿ࡽồࡵ࡚⤫ィⓗ࡟ィ ࡋࡓࠋࡑࡢ⤖ᯝࠊࠕⓎᩓゅ㸦❧యゅ㸧ࡢᣦᩘ㛵ᩘⓗศᕸ㸦ᣦᩘ๎㸧ࠖࡀㄆࡵࡽࢀࡓࠋࡇࡢ㡿ᇦ࡛ࡣ:ࡢᗘᩘศᕸࡢᑐᩘࢆྲྀ
ࡿࡇ࡜࡛ࠊⰋዲ࡞┤⥺㏆ఝࡀぢ࠸ࡔࡉࢀࡿࠋ>@ࡇࢀࡣ&XWࡢ඲ࢢ࣮ࣞࢻ SRRUa WUL H[FHOOHQW ࡢ
ヨᩱ࡟ᑐࡋ࡚ㄆࡵࡽࢀࡿ XQLYHUVDO UXOH ࡜ゝ࠼ࡿࠋྠ᫬࡟❧యゅ:ࡢప㡿ᇦ࡟ㄆࡵࡽࢀࡿᐃᛶ࡛ࡶ࠶ࡾࠊ
㧗ࢢ࣮ࣞࢻࡢヨᩱ 9*a WUL H[FHOOHQW ࡯࡝ࠊࡇࡢ
ࠕᣦᩘ๎ࠖ࠿ࡽ㐓⬺ࡍࡿഴྥࡀ࠶ࡿࠋ
㸦ࡘࡲࡾ┤⥺㏆ఝࡀ㐺⏝࡛ࡁࡿ㐃⥆ⓗ࡞ศᕸ࠿ࡽࠊ㞳ᩓⓗ࡛㧗࠸:ࡢᡂศࡸ┦ᑐᗘᩘࡀቑຍࡍࡿศᕸ࡬⛣⾜ࡍࡿࠋ㸧௒ᚋࡣࡇࡢࠕᣦᩘ๎ࠖࡢᐃᛶࢆ㋃ࡲ࠼ࡘࡘࠊ❧యゅ:ࡢศᕸ࡜ᩓ஘ගࡢᙉᗘ࡜ࡢ┦㛵ࠊᴟᗙᶆ᪉఩࡟ᑐ
ࡍࡿศᕸ␗᪉ᛶ࡞࡝࠿ࡽࠊᐆ▼ホ౯࡟ᑐࡍࡿගᏛ≀ᛶࡢಖドࢆ᥈ࡿࠋཧ⪃ᩥ⊩>@ 6FKXPDQQ:³GEMSTONES of the World³
/RQGRQ1$*3UHVV
>@ ᕝཱྀࠊ௚ࠊ➨ 61 ᅇ ᛂ⏝≀⌮Ꮫ఍᫓ᏘᏛ⾡ㅮ₇఍ࠊ S)   㸦ྠ㸧  S)   >@ ᕝཱྀࠊ௚ࠊ➨ 63 ᅇ ᛂ⏝≀⌮Ꮫ఍᫓ᏘᏛ⾡ㅮ₇఍ࠊ D6   >@ ᕝཱྀࠊ௚ࠊ᪥ᮏⰍᙬᏛ఍ㄅ ➨ 45 ᅇ඲ᅜ኱఍
Ⓨ⾲ㄽᩥ㞟ࠊ & 㻔㻼㻝㻟㻕 %± ᑠᆺከ┠ⓗ୰ᛶᏊᅇᢡィᘓタࡢ㐍ᤖ≧ἣ㸦ி኱ཎᏊ⅔ࠊ.(.ࠊⲈᇛ኱ࠊி኱㝔ᕤ㸧‫ۑ‬ᑠ㔝ᑎ㝧ᖹࠊ᳃୍ᗈࠊྜྷ㔝Ὀྐࠊబ⸨⠇ኵࠊᖹ㈡ᬕᘯࠊ
ࠉᒾ℩ㅬ஧ ࠊሷ㔝㈗኱ ࠊᯇ⏣ᾈᖹ 㸯㸬ࡣࡌࡵ࡟
 ㏆ᖺࠊ≀⌮࣭໬Ꮫ⣔ศ㔝࡟ຍ࠼࡚ࠊᕤᏛ⣔ศ㔝㸦≉࡟ࠊ࢚ࢿࣝࢠ࣮ᮦᩱ⣔ศ㔝㸧ࡢ◊✲⪅࣭ᢏ⾡⪅࡟ࡼࡿ୰ᛶᏊࡢ฼⏝ࡀ㣕㌍ⓗ࡟ቑຍࡋ࡚࠸ࡿࠋࡑࡢ኱ࡁ
࡞⌮⏤ࡢ㸯ࡘ࡜ࡋ࡚ࠊ୰ᛶᏊࢆ฼⏝ࡍࡿࡇ࡜࡛ࠊ≀㉁୰ࡢ㍍ඖ⣲㸦Ỉ⣲ࠊࣜࢳ࣒࢘ཬࡧ㓟⣲࡞࡝㸧ࡢཎᏊᏑᅾ఩⨨ࢆ⢭ᗘⰋࡃỴᐃ࡛ࡁࡿࡇ࡜ࡀᣲࡆࡽࢀࡿࠋ
Ỉ⣲྾ⶶᮦᩱࠊࣜࢳ࣒࢘஧ḟ㟁ụཬࡧ⇞ᩱ㟁ụࡢࡼ࠺࡟ࠊ࢚ࢿࣝࢠ࣮ᮦᩱࡢ࣮࢟ඖ⣲ࡀ㍍ඖ⣲࡛࠶ࡿࡇ࡜࠿ࡽࠊ୰ᛶᏊࡣ௒ᚋࡢ࢚ࢿࣝࢠ࣮ᮦᩱ◊✲࡟࠾࠸࡚ᚲせ୙ྍḞ࡞ ᐃࣉ࣮ࣟࣈ࡛࠶ࡿ࡜ゝ࠼ࡿࠋ㻌ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤࡢ◊✲⏝ཎᏊ⅔㸦.85㸧ࡢ%± ᐇ㦂Ꮝ࡟ࡣ༢⤖ᬗ⏝㸲㍈୰ᛶᏊᅇᢡィ㸦&1'㸧ࡀタ⨨ࡉࢀ࡚࠸ࡓࡀࠊ⪁ᮙ໬࡟ࡼࡗ࡚✌ാ⋡ࡀప㏞ࡋ࡚࠸ࡓࠋࡋ࠿ࡋ࡞ࡀࡽࠊ%± ᐇ㦂Ꮝࡣ  QVāFP㸦ヨᩱ఩⨨ࠊ0: 㐠㌿᫬㸧ࡢ୰ᛶᏊࣅ࣮࣒ᙉᗘࢆ᭷
ࡋ࡚࠾ࡾࠊ୰ᛶᏊἼ㛗ࡶ  c ࡜▷ࡃࠊᗈ࠸㐠ື㔞✵㛫㸦Q ✵㛫㸧࡛୰ᛶᏊᅇᢡᙉᗘࢆほ ࡍࡿࡇ࡜ࡀྍ
⬟࡛࠶ࡿࠋࡑࡢࡓࡵࠊ୰ᛶᏊࣂࢵࢡࢢࣛ࢘ࣥࢻࢆᴟ
ຊపῶࡍࡿࡇ࡜ࡀ࡛ࡁࢀࡤࠊ.85 ඹྠ฼⏝⿦⨨࡜ࡋ࡚༑ศ࡟ά⏝ࡍࡿࡇ࡜ࡀ࡛ࡁࡿ࡜⪃࠼ࡽࢀࡿࠋ
௨ୖࡢࡼ࠺࡞⌮⏤࠿ࡽࠊ⌧ᅾࠊ%± ᐇ㦂Ꮝ࡟ᑠᆺከ┠ⓗ୰ᛶᏊᅇᢡィࢆタ⨨ࡍࡿసᴗࡀ㐍ࡵࡽࢀ࡚࠸
ࡿࠋᮏⓎ⾲࡛ࡣࠊࡇࢀࡲ࡛ࡢ⿦⨨ᘓタࡢ㐍ᤖ≧ἣ࡟ࡘ࠸࡚⤂௓ࡍࡿࠋ
㸰㸬⿦⨨௙ᵝᅗ㸯࡟ᑠᆺከ┠ⓗ୰ᛶᏊᅇᢡィ㸦࢖࣓࣮ࢪᅗ㸧ࢆ♧ࡍࠋ% ᐇ㦂Ꮝࡢୖὶ㒊㸦ࣇ࢓࢖ࣥࢥ࣓࣮ࣜࢱ㒊ཬࡧࣔࣀࢡࣟࢣ࣮ࣈ㒊㸧࡟ࡘ࠸࡚ࡣ୍㒊ኚ᭦ࢆ⾜࠸ࠊୗὶ㒊㸦㸲ࢧ࣮ࢡ࣭ࣝࢦࢽ࣓࣮࢜ࢱ㒊ཬࡧ࣓࢖࣭ࣥ
࢝࢘ࣥࢱ࣮㒊㸧࡟ࡘ࠸࡚ࡣ᪂タసᴗࢆ⾜࠺ࠋࡲࡎୖ
ὶ㒊࡟㛵ࡋ࡚ࡣࠊ%& ࣞࢪࣥ࠾ࡼࡧ㔜ࢥࣥࢡ࣮ࣜࢺࢆタ⨨ࡍࡿࡇ࡜࡟ࡼࡿ㐽ⶸࡢᙉ໬ࢆ⾜࠺ࠋࡲࡓࠊ&Xࣔࣀࢡ࣓࣮ࣟࢱ࿘㎶࡟㛵ࡋ࡚ࡣ⪁ᮙ໬ࡀ⃭ࡋ࠸᪤Ꮡࡢࣔࣀࢡ࣓࣮ࣟࢱᯫྎࢆ᧔ཤࡋࠊ࣮ࣜࣔࢺ࡛ไᚚྍ
⬟࡞᪂ࡋ࠸ᯫྎࢆస〇࣭タ⨨ࡍࡿࠋࡉࡽ࡟ࠊ&X 䝰䝜䜽䝻䝯䞊䝍┤ᚋ䠄ୗὶഃ䠅䛻᪂タ䛧䛯䝡䞊䝮䝅䝱䝑䝍䞊䛻䛴䛔䛶䛿䚸ࡼࡾᏳ඲࡟ᐇ㦂ࢆ⾜࠺ࡓࡵ࡟ࠊࣅ࣮࣒ࢩࣕ
ࢵࢱ࣮࡜㐃ືࡋࡓ୰ᛶᏊࣅ࣮࣒ࡢ⾲♧ⅉࢆ᪂ࡓ࡟タ⨨ࡍࡿࡇ࡜࡟ࡍࡿࠋୗὶ㒊࡟㛵ࡋ࡚ࡣࠊ㸲ࢧ࣮ࢡ࣭ࣝ
ࢦࢽ࣓࣮࢜ࢱࢆ᧔ཤࡋࠊ㸰㍈ࢦࢽ࣓࣮࢜ࢱ㸦+XEHU㸭㸧ࢆタ⨨ࡍࡿࠋࡑࡢ㝿ࠊ&X 䝰䝜䜽䝻䝯䞊䝍䛛䜙ヨᩱ䜎䛷䛾㊥㞳䠄L䠅䛿 PP 䛸䛩䜛䚹+XEHU ࡢ࢔࣮࣒ୖ࡟᪂タࡢ᳨ฟჾࣂࣥࢡࢆྲྀ௜ࡅࡿࠋࡇࢀࡲ
࡛ &1' ࡢ࣓࢖࣭ࣥ࢝࢘ࣥࢱ࣮㒊࡛ࡣ %) ẚ౛ィᩘ⟶ࡀ  ᮏ౑⏝ࡉࢀ࡚࠸ࡓࡀࠊࡇࢀࢆ᧔ཤࡋࠊ᪂ࡓ࡟

+H 䜺䝇᳨ฟჾ䠄┤ᚄ䠖 䜲䞁䝏䚸᭷ຠ㛗䠖⣙  PP䠅䜢  ᮏᑟධ䛩䜛䚹+H 䜺䝇᳨ฟჾ䛿᪂タ䛾᳨ฟჾࣂࣥࢡෆ࡟   㛫㝸䛷ྲྀ௜ࡅࡿࠋᑦࠊヨᩱ䛛䜙᳨ฟჾ䜎䛷䛾㊥㞳䠄L䠅䛿 PP 䛷䛒䜛䚹 ᐃྍ⬟䛺ᅇᢡゅ䠄T䠅䛾⠊ᅖ䛿䚸   T    䛷䛒䜛䚹䛥䜙䛻䚸ධᑕ୰ᛶᏊ
䝡䞊䝮䜹䜴䞁䝍䠄ᅇᢡ䝕䞊䝍つ᱁໬⏝䠅ཬ䜃୰ᛶᏊ䝡䞊䝮䝁䝸䝯䞊䝍䜢タ⨨䛩䜛䚹ᑦ䚸ࢦࢽ࣓࣮࢜ࢱࡢไᚚࠊ୰
ᛶᏊᩘࡢィ ࠊ➼࡟ࡘ࠸࡚ࡣࠊࡍ࡭࡚ࢆࣃ࣮ࢯࢼࣝ
ࢥࣥࣆ࣮ࣗࢱ࣮ୖ࡛⾜࠼ࡿࡼ࠺࡞ ᐃࢩࢫࢸ࣒ࢆ᪂
ࡓ࡟ᑟධࡍࡿࠋ+XEHU ࡣヨᩱᅇ㌿ࢫࢸ࣮ࢪ࡜ࡋ࡚
౑⏝ࡋࠊࢡࣛ࢖࣑࢜ࢽ࡞࡝ࡢ࿘㎶ᶵჾࡀタ⨨࡛ࡁࡿࡼ࠺࡟ࡍࡿࠋ
㸱㸬㐍ᤖ≧ἣ ᫖ᖺᗘ࡟⾜ࡗࡓୖὶ㒊㸦◊✲⅔ഃ㸧ࡢ㛤ᨺⅬ᳨ࢆᶵ࡟ࣃࣛࣇ࢕ࣥ➼ࡢྂ࠸㐽ⶸయࢆ᧔ཤࡋࠊ㐽ⶸᙉ໬సᴗࢆᐇ᪋ࡋ࡚࠸ࡿࠋࣇ࢓࢖ࣥࢥ࣓࣮ࣜࢱ㒊࡟ࡘ࠸
࡚ࡣ %& ࣞࢪࣥࢆ᪂ࡓ࡟స〇ࡋࠊ㔜ࢥࣥࢡ࣮ࣜࢺࣈ
ࣟࢵࢡࢆタ⨨ࡍࡿࡇ࡜࡟ࡼࡿ㐽ⶸࡢᙉ໬ࢆ㐍ࡵ࡚࠸
ࡿࠋ&X ࣔࣀࢡ࣓࣮ࣟࢱ㒊࡟ࡘ࠸࡚ࡣ  ㍈ࢫࢸ࣮ࢪࣘ
ࢽࢵࢺࢆഛ࠼ࡓ᪂ࡋ࠸ᯫྎࢆస〇࣭タ⨨ࡋࡓࠋࡉࡽ
࡟ࠊ᫖ᖺᗘ࡟᪂タࡋࡓ䝡䞊䝮䝅䝱䝑䝍䞊䛻䛴䛔䛶䛿䚸୰ᛶᏊ䝡䞊䝮⾲♧ⅉ䛾ྲྀ䜚௜䛡䜢⾜䛳䛯䚹⌧ᅾ䛿䚸㸰㍈ࢦࢽ࣓࣮࢜ࢱ㸦+XEHU㸭㸧࡟ᤣ࠼௜ࡅࡿ +H 䜺䝇᳨ฟჾ䝞䞁䜽䛾స〇ࢆ㐍ࡵ࡚࠸ࡿࠋ

)LJ   7KH VFKHPDWLFSHUVSHFWLYH YLHZ RI WKH FRPSDFWPXOWLSXUSRVH QHXWURQ GLIIUDFWRPHWHU RQ WKH %± EHDPSRUWRI.85

&XUUHQWVWDWHVIRUGHYHORSPHQWRIWKHFRPSDFWPXOWLSXUSRVHQHXWURQGLIIUDFWRPHWHURQWKH%±EHDPSRUW<RKHL2QRGHUD.D]XKLUR 0RUL  +LURIXPL<RVKLQR 6HWVXR6DWR+DUXKLUR+LUDND.HQML ,ZDVH7DNDKLUR6KLRQR.RKHL0DWVXGD&RUUHVSRQGLQJDXWKRU(PDLODGGUHVVNPRUL#UULN\RWRXDFMS .0RUL 㻙 㻞㻣㻌㻙

㻔㻼㻝㻠㻕 ⚟ᓥཎⓎ஦ᨾ࡟ࡼࡿ᪥ᮏ⏘ࣇࢺ࣑࣑ࢬᒓ㸦*HQXVPheretima㸧࡬ࡢᨺᑕᛶࢭࢩ࣒࢘ࡢ⛣⾜࡜యෆືែ
㸦ி኱㝔㎰ ࠊᮾி㎰኱ ࠊி኱ཎᏊ⅔ 㸧‫⏣ۑ‬୰ⲡኴ ࠊ㊊㐩ኴ㑻 ࠊ⸨ཎ៞Ꮚ ࠊ㧗ᶫ▱அ ࠊ㧗ᶫ༓ኴ㑻 㸯㸬ࡣࡌࡵ࡟㸸ᮾி㟁ຊ⚟ᓥ➨୍ཎᏊຊⓎ㟁ᡤ஦ᨾ࡟ࡼࡗ࡚ࠊ኱㔞ࡢᨺᑕᛶ≀㉁ࡀ⎔ቃ୰࡟ᨺฟࡉࢀࡓࠋ
⚟ᓥ┴ࡣ⥲㠃✚ࡢ⣙  ๭ࡀ᳃ᯘ࡟そࢃࢀ࡚࠾ࡾࠊᨺ
ᑕᛶ≀㉁ࡢከࡃࡣ᳃ᯘ⏕ែ⣔࡟ྲྀࡾ㎸ࡲࢀࡓࠋ≉࡟ᨺᑕᛶࢭࢩ࣒࢘㸦&V㸧ࡣࠊ⏕ែ⣔ࡢ≀㉁ᚠ⎔࡟ࡼࡗ࡚᫬㛫⤒㐣࡜࡜ࡶ࡟᳃ᯘࡢᯘᗋ㒊࡟⵳✚ࡋࠊ㛗ᮇⓗ࡟ಖᣢࡉࢀࡿഴྥࡀ࠶ࡿࠋࡇࢀࡽࡢ &V ࡀ⵳✚ࡋࡓ᭷ᶵ≀ࢆᦤ㣗ࡋࠊᅵተࢆᵓᡂࡍࡿ࣑࣑ࢬࡣࠊ&V ࡢᆅ୰㖄┤᪉ྥ࡬ࡢ⛣ືࡢ୍ᅉ࡜࡞ࡗ࡚࠸ࡿ࡜⪃࠼ࡽࢀ࡚
࠸ࡿ>@ࠋࡉࡽ࡟ࠊ࣑࣑ࢬ࡞࡝ࡢ⭉㣗ᛶ⏕≀ࡣ௚ࡢ⏕≀ࡢ㔜せ࡞㣵㈨※࡜࡞ࡗ࡚࠾ࡾࠊ㣗≀㐃㙐ࢆ㏻ࡋࡓ
&V ࡢ⛣⾜⤒㊰ࡢ㉳※࡜࡞ࡗ࡚࠸ࡿ>@ࠋࡑࡢࡓࡵࠊ࣑
࣑ࢬࡣ &V ࡢ㛗ᮇⓗ࡞⏕ែ⣔ືែࢆᢕᥱࡍࡿ࠺࠼࡛㔜せ࡞⏕≀࡛࠶ࡿࠋ
ࡲࡓࠊᅵተ⾲ᒙ࡟ᐃఫࡋ࡚࠸ࡿ⾲ᒙᛶ࣑࣑ࢬࡣ௚
ࡢ⏕≀࡜ẚ㍑ࡋ࡚ࠊ㧗࠸⥺㔞ࢆ㛗ᮇⓗ࡟ཷࡅࡿࠋࡇ
ࡢࡓࡵࠊࢳ࢙ࣝࣀࣈ࢖ࣜཎⓎ஦ᨾ࡛ࡣࠊ⣙ *\ ࡢ⿕ࡤࡃ⥺㔞ࢆཷࡅࡓ࣑࣑ࢬࢆྵࡴᅵተ⏕≀ࡢ⏕ᜥᩘࡸ✀ከᵝᛶࡢపୗࡀሗ࿌ࡉࢀࡓ>@ࠋࡇࢀࡽᨺᑕ⥺ࡢ⏕ែ⣔ᙳ㡪ࢆᢕᥱࡍࡿ࠺࠼࡛࣑࣑ࢬࡣᣦᶆ࡜࡞ࡿ⏕≀࡜ࡋ࡚ࠊᅜ㝿ᨺᑕ⥺㜵ㆤጤဨ఍㸦,&53㸧࡟ࡼࡾᶆ‽ື≀࡟ᣦᐃࡉࢀ࡚࠸ࡿ>@ࠋࡋ࠿ࡋ࡞ࡀࡽࠊ᪥ᮏ࡛
ඃ༨ⓗ࡟⏕ᜥࡍࡿࣇࢺ࣑࣑ࢬ⛉ࣇࢺ࣑࣑ࢬᒓ࡟㛵ࡋ࡚ࡣࠊ࣮ࣚࣟࢵࣃ࡛ඃ༨ࡍࡿࢶ࣑࣑ࣜࢬ⛉࡜ẚ㍑ࡋ
࡚ศ㢮ࢆྵࡴᇶ♏ⓗ◊✲ࡀ㐍ࢇ࡛࠾ࡽࡎࠊ&V ࡢືែ࣭ᙳ㡪࡟㛵ࡋ࡚ࡶࢹ࣮ࢱࡀ୙༑ศ࡛࠶ࡿ>@ࠋ᪥ᮏࡢ᳃ᯘ⏕ែ⣔࡟࠾ࡅࡿ &V ࡢ㛗ᮇⓗ࡞ືែࢆゎ᫂ࡋࠊ⏕ែ⣔࡟ཬࡰࡍᙳ㡪ࢆṇ☜࡟ホ౯ࡍࡿࡓࡵࠊࣇࢺ࣑
࣑ࢬᒓ࡬ࡢ &V ࡢ⛣⾜≧ἣ࡜యෆືែ࡟㛵ࡋ࡚ࠊㄪᰝ࣭ᐇ㦂ࢆ࠾ࡇ࡞ࡗࡓࠋ
㸰㸬◊✲᪉ἲ㸸 ᖺ࠿ࡽ  ᖺࡢ  ࣧᖺ㸦᫬ᮇ ᭶㸧ࠊཎⓎ࠿ࡽ໭す⣙ NP ࡢⴠⴥᗈⴥᶞࢆ୺࡜ࡍࡿ
ᒣᯘ࡛ࠊ⾲ᒙᛶࣇࢺ࣑࣑ࢬᒓࡢ࣑࣑ࢬ࡜⏕ᜥᆅࡢࣜࢱ࣮ཬࡧᅵተ㸦FP㸧ࢆ᥇㞟ࡋࡓࠋ&V ࡢᐃ㔞ࡣࠊࢤ࣐ࣝࢽ࣒༙࢘ᑟయ᳨ฟჾ㸦*H ᳨ฟჾ㸧ࢆ⏝࠸࡚ࠊ࣐࢞ࣥ⥺ࢫ࣌ࢡࢺ࣓ࣟࢺ࣮ࣜἲ࡟ࡼࡗ࡚⾜ࡗࡓࠋࡲࡓࠊ࣑࣑ࢬࡢ⭠ࢆྵࡴෆ㒊ჾᐁཬࡧ➽⤌⧊ࢆศ㞳ࡋࠊ࢖࣓࣮ࢪࣥࢢࣉ࣮ࣞࢺ㸦%$6,306(㸧࡟  ᪥㛫ᐦ╔㟢ගࡉࡏࠊ࣑࣑ࢬ࡟⵳✚ࡋࡓ &V ࡢయෆศᕸࢆ⏬
ീ໬㸦$5*$XWRUDGLRJUDSK\㸧ࡋࡓࠋࡑࡢᚋࠊ⭠ࠊ➽⤌⧊ཬࡧࡑࡢ௚ࡢჾᐁ࡟ศࡅ࡚ *H ᳨ฟჾ࡛ &V ࡢᐃ㔞ࢆ⾜ࡗࡓࠋࡉࡽ࡟ࠊ&V ࡢ᤼ฟ㏿ᗘࢆ᫂ࡽ࠿࡟ࡍࡿ

ࡓࡵࠊ᥇㞟ࡋࡓ࣑࣑ࢬࢆ &V ࡢྵࡲࢀ࡚࠸࡞࠸ᅵተ࣭
ࣜࢱ࣮࡟⛣ࡋࠊయෆ⃰ᗘࡢ⤒᫬ⓗኚ໬ࢆ ᐃࡋࡓࠋ㸱㸬⤖ᯝ࡜⪃ᐹ㸸$5* ࡢ⤖ᯝࠊ&V ࡣ࣑࣑ࢬ⭠ෆ࡟㧗࠸⃰ᗘ࡛Ꮡᅾࡋ࡚࠾ࡾࠊ➽⤌⧊࡬ࡢ⛣⾜ࡣẚ㍑ⓗᑡ࡞࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡇࡢࡇ࡜࠿ࡽࠊ⭠ࠊ➽⤌⧊ཬࡧࡑࡢ௚ࡢჾᐁ࡟ศࡅ &V ࢆᐃ㔞໬ࡋࡓ⤖ᯝࠊ⭠ෆ࠿ࡽ➽⤌⧊࡬ࡢ &V ࡢ⛣⾜ࡣ⣙ 㸣࡛࠶ࡗࡓࠋࡲࡓࠊ
&V ࡢ᤼ฟ㏿ᗘࡢ ᐃ࠿ࡽࠊᦤ㣗࡟ࡼࡗ࡚యෆ࡟⛣⾜ࡋࡓ &V ࡣᛴ㏿࡟᤼ฟࡉࢀࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
ࡇࡢ⤖ᯝ࠿ࡽ࣑࣑ࢬ࡟㛵ࡋ࡚ࠊ&V ࡢ㧗⃰ᗘ࡞⏕≀⃰⦰ࡀ㉳ࡇࡿࡇ࡜ࡣ⪃࠼࡟ࡃࡃࠊ⏕ᜥ⎔ቃࡢ &V ⃰ᗘࡢኚື࡟౫Ꮡࡋ࡚ࠊయෆ &V ⃰ᗘࡀ᥎⛣ࡋ࡚ࡃ࡜ண ࡉࢀࡿࠋࣇ࢕࣮ࣝࢻㄪᰝࡢ⤖ᯝࠊ ᖺ࠿ࡽ  ᖺࡢ ࣧᖺ࡟࠾ࡅࡿ࣑࣑ࢬࡢ &V ⃰ᗘࡢ⤒ᖺῶᑡ⋡ࡣࠊ⣙࡛࠶ࡗࡓࠋࡇࡢࡇ࡜࠿ࡽ࣑࣑ࢬࢆྵࡴ⭉㣗ᛶ⏕≀⩌࡛ࡣࠊయෆࡢ &V ࡀ㛗ᮇⓗ࡟㧗⃰ᗘ࡟⥔ᣢࡉࢀ࡚࠸ࡃ࡜᥎ ࡉࢀࡿࠋࡑࡢࡓࡵࡇࢀࡽࢆᦤ㣗ࡍࡿୖ఩ᰤ㣴ẁ㝵ࡢ⏕≀✀࡬ࡢ &V ࡢ⛣⾜ࡀᠱᛕࡉࢀࡿࠋ᳃ᯘ
⏕ែ⣔࡟࠾ࡅࡿ &V ࡣࠊ᫬㛫⤒㐣࡜࡜ࡶ࡟ᐃᖖ≧ែ࡟㏆࡙࠸࡚࠸ࡃ࡜⪃࠼ࡽࢀࡿࡓࡵࠊ㛗ᮇⓗ࡞ືែࢆண
ࡍࡿࡓࡵ࡟ࡣࠊ⏕≀ࡢ㣗≀㐃㙐ࢆ㏻ࡋࡓ⛣ື࣭ᣑᩓࢆṇ☜࡟ᢕᥱࡋ࡚࠸ࡃᚲせࡀ࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋཧ⪃ᩥ⊩>@ ྜྷ⏣⪽ ³᳃ᯘ࡟࠾ࡅࡿᨺᑕᛶ≀㉁ࡢືែ´ ᮧᯇᗣ⾜࡯࠿㸦⦅㸧 ࠗᨺᑕ⥺࡜ᆅ⌫⎔ቃ⏕ែ⣔࡬ࡢᙳ㡪ࢆ⪃࠼ࡿ࠘ ◊ᡂ♫  
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࠾ࡼࡧ Pdࡢ⏘ᴗ฼⏝ࡢ⌧≧࡜⎔ቃືែ㸸㻔㻼㻝㻡㻕  Zr࠾㛗ᑑ࿨᰾ศ⿣᰾✀ࡢ෌฼⏝࡟క࠺⿕ࡤࡃ⥺㔞ࡢホ౯ࡢほⅬ࠿ࡽ
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㸦ி኱㝔㎰ ࠊி኱ཎᏊ⅔ 㸧‫ۑ‬ᒾ⏣ె௦Ꮚ ࠊ⏣୰ⲡኴ ࠊ㧗ᓥ┤㈗ ࠊ㧗ᶫ▱அ ࠊ㧗ᶫ༓ኴ㑻㸯㸬ࡣࡌࡵ࡟ 㛗ᑑ࿨᰾ศ⿣⏕ᡂ≀࡟ྵࡲࢀࡿࣞ࢔
࣓ࢱࣝ᰾✀ࡸⓑ㔠᪘᰾✀ࢆᏳᐃ᰾✀࡟ኚ᥮ࡋࠊ㈨※࡜ࡋ࡚෌฼⏝ࡍࡿࡓࡵࡢ◊✲ࣉࣟࢪ࢙ࢡࢺࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋࡑࡢሙྜࠊᅇ཰ࡉࢀࡓ㔠ᒓ࡞࡝࡟ྵࡲࢀ
ࡿᨺᑕᛶ᰾✀࡟ࡼࡗ࡚⏕ࡌࡿᨺᑕ⥺⿕ࡤࡃᙳ㡪㸦ᨺᑕ⥺㞀ᐖ㸧ࢆᮍ↛࡟㜵Ṇࡍࡿ᪉⟇ࢆ☜❧ࡋ࡚࠾ࡃᚲ
せࡀ࠶ࡿࠋᮏ◊✲ࡣࠊ෌฼⏝ࡀ᝿ᐃࡉࢀ࡚࠸ࡿࢪࣝ
ࢥࢽ࣒࢘㸦=U㸧࠾ࡼࡧࣃࣛࢪ࣒࢘㸦3G㸧࡟ࡘ࠸࡚ࢡ
ࣜ࢔ࣛࣥࢫࣞ࣋ࣝࢆタᐃࡍࡿࡇ࡜ࢆ᭱⤊┠ᶆ࡜ࡋࠊձᅇ཰࠿ࡽ〇㐀ࠊᗫᲠ࡟࠸ࡓࡿ㐣⛬㸦ࣛ࢖ࣇࢧ࢖ࢡ
ࣝ㸧ࠊղ⫋ᴗ⎔ቃ࡞ࡽࡧ࡟⮬↛⎔ቃ୰࡛ࡢືែࠊճே
࡬ࡢᦤྲྀ࡜ෆ㒊⿕ࡤࡃ⥺㔞ホ౯ࠊࡢ  㡯┠࡟ࡘ࠸࡚ㄪᰝ◊✲ࢆᐇ᪋ࡋࡓࠋ
㸰㸬ㄪᰝࡢᴫせ ձࡢࣛ࢖ࣇࢧ࢖ࢡࣝㄪᰝ◊✲࡛ࡣࠊ
Zr ࡜ Pd ࡑࢀࡒࢀࡢ⏘ᴗ฼⏝ࠊᅜෆ࡛ࡢ฼⏝≧ἣࠊ࠾ࡼࡧࣜࢧ࢖ࢡࣝࡢ⌧≧ࢆࠊղ࡛ࡣࠊ⎔ቃ୰ࡸ⏕ែ⣔ෆ࡛ࡢືែ࡟㛵ࡍࡿඛ⾜◊✲࡟ࡘ࠸࡚ࠊճ࡛ࡣࠊ
ྛ᰾✀ࡢ୍⯡⎔ቃ࡛ࡢᦤྲྀ㔞࠾ࡼࡧయෆືែ࡜ẘᛶࢆ୰ᚰ࡟ࠊㄪᰝࢆ⾜ࡗࡓࠋ㸱㸬ㄪᰝ⤖ᯝ ձZr㸸ࢪࣝࢥࣥ㸦ZrSiO4㸧ࡸࣂࢹࣛ࢖ࢺ㸦ZrO2㸧ࡢᙧែ࡛᥇ྲྀࡉࢀࠊࢪࣝࢥࣥ⣔ࡸࢪࣝࢥࢽ࢔⣔ࡢ⪏ⅆ≀࠾ࡼࡧ㟁Ꮚᮦᩱ࡞࡝ࡢ〇ရ࡟฼⏝ࡉࢀࡿ[1]ࠋᅜෆ࡛ࡢ฼⏝≧ἣࡣࠊ2005-2014 ᖺࡢ㛫࡟ᖺ㛫 12,383-18,302 ࢺࣥ㸦⣧ศ㸧฼⏝ࡉࢀ࡚࠾ࡾࠊ
ࡑࡢ୰࡛ࡶ⪏ⅆ≀〇ရࡀᖹᆒࡋ࡚඲యࡢ 66%ࢆ㉸࠼࡚࠸ࡿ[2]ࠋPd㸸᥇ྲྀࡉࢀࡓࣃࣛࢪ࣒࢘ᆅ㔠ࡣ⮬ື㌴᤼࢞ࢫί໬⏝ࡢゐ፹ࠊṑ⛉⏝ᮦᩱࠊᐆ㣭ရ࡞࡝࡜ࡋ
࡚฼⏝ࡉࢀ࡚࠸ࡿ[3,4]ࠋᅜෆ࡛ࡣᖺ㛫ᖹᆒ 94.3 ࢺࣥ㸦⣧ศ㸧฼⏝ࡉࢀ࡚࠾ࡾࠊ௦⾲ⓗ࡞㟂せࡣゐ፹࡛࠶ࡾࠊᖹᆒࡋ࡚඲యࡢ 46%ࢆ༨ࡵࡿ[3]ࠋ
ղZr㸸⎔ቃ୰࡛ࡢ Zr ࡢᣲື࡟㛵ࡋ࡚ࡣ 95Zr ࢆࢺ࣮ࣞࢧ࡜ࡋ࡚౑⏝ࡋࡓ◊✲ࡀ࠶ࡿࠋỈ⏣⎔ቃ࡟࠾࠸࡚ࠊ
⾲ᒙỈ࡟ῧຍࡉࢀࡓ 95Zr ࡣᛴ㏿࡟ῶᑡࡋࠊ1 㐌㛫ᚋ࡟ࡣึᮇ⃰ᗘࡢ 1.83%ࡲ࡛ῶᑡࡋࡓ[5]ࠋ⾲ᒙỈ୰ࡢ
95Zr ࡣᛴ㏿࡟✄ࡢ᰿ࡸⱼ࡟⛣⾜ࡍࡿࡀࠊᅵተ⾲ᒙ࡟ỿ╔ࡋࡓ 95Zr ࡣ⾲ᒙ࠿ࡽ 0-8 cm ࡢ῝ࡉ࡟⁫␃ࡋࠊ✄࡟ࡣ྾཰ࡉࢀ࡟ࡃ࠸ࡇ࡜ࡀ♧ࡉࢀࡓ[5]ࠋPd㸸኱Ẽ୰ࡢ Pd ࢆྵࡴⓑ㔠᪘ඖ⣲ࡢ⃰ᗘࡣࠊ⮬ື㌴ゐ፹࡜ࡋ࡚ࡢ฼⏝ࡀ㧗ࡲࡿ 1990 ᖺ௦࡟ࣂࢵࢡࢢࣛࣥࢻࣞ
࣋ࣝ࡟ᑐࡋ࡚ 40-120 ಸ࡟ᛴ⃭࡟ቑຍࡋࡓ[6]ࠋ኱Ẽ୰࡟⢊ሻ࡜ࡋ࡚ᨺฟࡉࢀࡓⓑ㔠᪘ࡣࠊᵝࠎ࡞⤒㊰ࢆ⤒࡚ࠊ⏕ែ⣔࡟ྲྀࡾ㎸ࡲࢀࡿࠋ⏕≀࡟ྲྀࡾ㎸ࡲࢀࡓⓑ㔠᪘ࡢ⃰⦰࡞࡝ࢆㄪᰝࡋࡓ◊✲ࡢࡦ࡜ࡘ࡟஧ᯛ㈅ࢆ⏝࠸ࡓᐇ㦂ࡀ࠶ࡿ[7]ࠋPd ࡣ௚ࡢⓑ㔠᪘࡟ẚ࡭ࠊࠊẚ㍑ⓗ⏕≀⃰⦰ࢆ㉳ࡇࡋࡸࡍ࠸࡜࠸࠺ഴྥࡀ♧ࡉࢀࡓࠋῐỈ⏕⏥Ẇ㢮ࡸ᳜≀࡟࠾࠸࡚ࡶྠᵝࡢ⤖ᯝࡀᚓࡽࢀ࡚࠸ࡿ[8, 9]ࠋ
ճZr㸸୍⯡ࡢ㣗ရ࣭Ỉ࠿ࡽࡢ⤒ཱྀᦤྲྀ㔞ࡣ࠾ࡼࡑ 4
mg/᪥ࠊ྾ධ㔞ࡣ 30.8 μg/᪥࡜᥎ᐃࡉࢀ࡚࠸ࡿ[10,11]ࠋᾘ໬⟶࠿ࡽࡢ྾཰⋡ࡣపࡃ[12]ࠊ⾑Ύ୰ࡢ⏕≀Ꮫⓗ༙ῶᮇࡣ୍ḟ࣭஧ḟᡂศࡀࡑࢀࡒࢀ 0.8-3.6 ᫬
㛫࣭3 ᪥࡛࠶ࡿ[13]ࠋ୍᪉྾ධᚋࡢ⫵࡛ࡢ⏕≀Ꮫⓗ༙ῶᮇࡣࡑࢀࡒࢀ⣙ 70࣭225 ᪥࡛࠶ࡗࡓ[14]ࠋPd㸸㣗ရ࣭Ỉ࠿ࡽࡢ 1 ᪥࠶ࡓࡾࡢ⤒ཱྀᦤྲྀ㔞ࡣࡑࢀࡒࢀ 2μg ௨ୗ࣭0.03 μgࠊ྾ධ㔞ࡣ᭱኱ 0.0003 μg ࡜᥎ᐃࡉࢀ࡚࠸ࡿ[15]ࠋయෆ࡟ධࡗࡓ Pd ࡢ྾཰⋡ࡣࠊᾘ໬⟶ࡼࡾẼ⟶ෆࡢ᪉ࡀࡼࡾ㧗࠸ࡇ࡜ࡀື≀ᐇ㦂࠿ࡽศ࠿ࡗ࡚࠸ࡿ[16-17]ࠋ
Zr࣭Pd ࡜ࡶ࡟ᐇ㦂ᩘ㸦≉࡟ேࡢ⣽⬊࠾ࡼࡧయᾮࢆ⏝࠸ࡓᐇ㦂㸧ࡀ㝈ࡽࢀ࡚࠸ࡿࡓࡵࠊ௒ᚋࡣ⌧Ꮡࡍࡿࢹ࣮ࢱࢆྲྀࡾࡲ࡜ࡵࠊ᳨ドࡢࡓࡵࡢᐇ㦂◊✲ࢆ⾜࠺ᚲ
せࡀ࠶ࡿࠋ
ཧ⪃ᩥ⊩
[1] ᨺᑕ⥺་Ꮫ⥲ྜ◊✲ᡤ ⮬↛㉳※ᨺᑕᛶ≀㉁㸦NORM㸧ࢹ࣮ࢱ࣮࣋ࢫ ࢪࣝࢥࢽ࣒࢘㖔▼.
[2] (⊂)▼Ἔኳ↛࢞ࢫ࣭㔠ᒓ㖔≀㈨※ᶵᵓ 㖔≀㈨※࣐ࢸࣜ࢔ࣝࣇ࣮ࣟ2010ࢪࣝࢥࢽ࣒࢘㸦Zr㸧.
[3] ྠୖ 2007 ࣃࣛࢪ࣒࢘㸦Pd㸧
[4] ྠୖ 2015 ⓑ㔠᪘㸦PMG㸧
[5] Shi et al., 2002. Dynamics of 95Zr in the rice/ water/ soil system. Applied
Radiation and Isotopes. 56, 753-740.
[6] Moldovan, 2007. Origin and fate of platinum group elements in the environment. Anal. Bioanal. Chem. 388, 537-540.
[7] Zimmerman et al., 2002. Biological availability of traffic-related platinum-group elements (palladium, platinum, and rhodium) and other metals to thezebra mussel (Dreissena polymorpha) in water containing road dust. Environ.
Toxicol. Chem. 12, 2713-2818.
[8] Moldovan et al., 2001. Bioaccumulation of Palladium, Platinum and Rhodium
from urban particulates and sediments by the fresh water isopod Asellus Aquatics.
Water Research. 35, 17, 4175-4183.
[9] Schafer et al. 1998. Uptake of traffic-related heaby metals and platinum groupelements (PGE) by plants. Sci. Total Environ. 215, 56-67.
[10] Schroeder et al., 1966. Abnormal tracemetals in man: Zirconium. J. Chron.
Dis. 19, 573-586.
[11] ⡿ᣢࡽ,2016. ᕼᅵ㢮ඖ⣲㸦ࣞ࢔࢔࣮ࢫ㸧࡟╔┠ࡋࡓ୰ᅜ኱㒔ᕷ࡜㤳㒔
ᅪࡢ PM2.5 ࡢඖ⣲ᡂศ࡜Ⓨ⏕※ࡢ≉ᚩ. ኱Ẽ⎔ቃᏛ఍ㄅ. 51(1), 33-43.
[12] International Commission on Radiological Protection, 1975. Report of the
Task Group on Reference Man. Oxford: Pergamon Press; ICRP Publication 23.
[13] Veronese, et al. 2003. A re-evaluation of the biokinetics of zirconium inhumans. Appl. Radiat. Isot.58, 431-439.
[14] Health Council of the Netherlands: Committee on Updating of Occupational
Exposure Limits, 2002. Zirconium and zirconium compounds; Health-based
Reassessnebt of Administrative Occupational Exposure Limits. 2000/15OSH/059.
[15] Kielhorn et al. 2002. Palladium-A review of exposure and effects to humanhealth. Int. J. Hyg. Environ. Health. 205, 417-432.
[16] Moore, W. et al. 1974. Biological fate of 103Pd in rats following different
routes of exposure. Environmental Research, 8: 234-240.
[17] Moore, W. et al. 1975. Preliminary studies on the toxicity and metabolism of
palladium and platinum. Environmental Health Perspectives, 10: 63-71.

ᮏ◊✲ࡣࠊ⥲ྜ⛉Ꮫᢏ⾡࣭࢖ࣀ࣮࣋ࢩࣙࣥ఍㆟ࡀ୺ᑟࡍࡿ 㠉᪂ⓗ◊✲㛤Ⓨ᥎㐍ࣉࣟࢢ࣒ࣛ㸦ImPACT㸧ࡢ୍⎔࡜ࡋ࡚ᐇ᪋ࡋࡓࡶࡢ࡛ࡍࠋ

Industrial use and environmental behavior of Zr and Pd: from the point of view of evaluating radiation dose in the reuse of long-lived
fission nuclides
Kayoko Iwata, Sota Tanaka, Naoki Takashima, Tomoyuki Takahashi Sentaro Takahashi
iwata.kayoko.86x@st.kyoto-u.ac.jp

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UV-vis vcÆâ² X éy¥Æ(Powder X-ray diffraction
[W PXRD)Ăą|ĒĖč(Transmitting electron
microscope[W TEM)$/2ôá5ð e¶Ğěè·ğ{ 1 &Ëf%ÇÄ$279TÈ%ç¢ Au:Ni=1:2.5(mM)% NPs % TEM ôÖa
! 2ÇÄ$6B>SITĊu)32{ 1-a %NPs %ã&¦ nm Þ#%$ÇÄ$6B>
S I T Ċ 5 u ) # { 1-b % NPs % ã  &50-100nm Þ"ē$#UV-vis vc
BM=DS0& Au NPs $Í°%LRCPTv
p%*ôÆ3JU=]ê..@KD
2-%- 1ã%Ć .ĒÎ¡%Ć 
mz! 2"ë 032)PXRD %è·Au%è¯ºĄÕ´"432 FCC %JU=$h0$¸%# FCC %JU=ôÆ3({2)3&ąn$~w3
2å Ni -&Au0.5Ni0.5 sČ%HS=è¯"-Ø#2EGãj2"$/ ÍØ#è¯ºĄÙÑqì ë 032Fig. 1. TEM images of Au-Ni
NPs that the ratio of
ion concentrations in the solution is Au:Ni=1:2.5 (a:The solution includes ascorbic acid, b: The solution
don’t includes ascorbic acid)

Fig. 2. PXRD patterns of Au-Ni NPs that the ratio of
ion concentrations in the solution is Au:Ni=1:2.5(The solution don’t includes ascorbic acid)oë§Ï[1] Chunhua Cui et al. Nature Mater., 12 (2013) 765-771[2] Xiaofeng Wang, et al. Int. J. Hydrogen Energy, 39(2014) 905-916

Synthesis of multicomponent metal nano-particles by -ray irradiation reduction method
Shintaro Toda, Motoaki Tanaka, Akihiro Toukai, Hodaka Nakanishi, Masaumi Tani, Kenji Kozu, Katuaki Mizukoshi, Akihiro Iwase,
Masaaki Sakamoto, Xu Qiu, Huminobu Horis-toda@mtr.osakafu-u.ac.jp

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ࡢᚋ࡟ヨᩱࢆྠ᮲௳࡛

ᐃࢆ⾜࠺ࠋࡑ

ᐃࡋࠊྛⅬࡢࣂࢵࢡࢢࣛ࢘

ࣥࢻࢆᕪࡋᘬ࠸ࡓ࢝࢘ࣥࢺ࣮ࣞࢺ࡜఩⨨᝟ሗ࠿ࡽᙉ
ᗘศᕸᅗࢆᥥࡃࡇ࡜ࡀ࡛ࡁࡿࠋởᰁ᰾✀ࡀุ᫂ࡋ࡚
࠸ࡿሙྜࡣྛⅬࡢἼ㧗ࢫ࣌ࢡࢺࣝ࠿ࡽ ROI ࢆ࡜ࡿࡇ㸰㸬 ⿦⨨ࡢᴫせᑠᆺࡢᐇ㦂⿦⨨㸦50 L ࢻ࣒ࣛ⨁ࢧ࢖ࢬ⛬ᗘ㸧ࡀධࡿ኱ࡁࡉ࡛ࠊᨺᑕ⥺᳨ฟჾ࡜ ᐃᑐ㇟≀ࢆ⛣ືࠊᅇ㌿ࡉࡏࡿࡇ࡜࡟ࡼࡾࠊởᰁࡢ࣐ࢵࣆࣥࢢࡀྍ⬟࡞Ț⥺ᨺฟ᰾✀ởᰁ᳨ᰝ⿦⨨ࠋ࡜࡛ᙉᗘศᕸࢆࡼࡾ㩭᫂࡟ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ

≉ᚩ࢝࢘ࣥࢺ࣮ࣞࢺ࡛ᙉᗘࢆ⾲ࡋࡓ᪉ࡣ඲యࡀࡰࢇࡸࡾձ ኱ᆺࡢ CsI ࢩࣥࢳ࣮ࣞࢱ᳨࣮࡛ฟຠ⋡ࡀ㧗ࡃࠊ࢚ࢿࣝࢠ࣮ࢫ࣌ࢡࢺࣝࡶ࡜ࢀࡿࡢ࡛ࢫ࣌ࢡࢺࣝࢆ
ゎᯒࡍࡿࡇ࡜࡛᰾✀ࡢุูࡀ࡛ࡁࡿࠋ
ղ᳨ฟჾࢆ XY ᖹ㠃࡛⛣ືࠊ ᐃᑐ㇟≀ࢆᅇ㌿ࡉࡏࡿࡇ࡜࡛⮬ᕫ㐽ⶸࡢᑡ࡞࠸≧ែ࡛ຠ⋡ⓗ࡞ ᐃࡀྍ⬟࡛ࠊ ᐃჾࡢ఩⨨᝟ሗ࠿ࡽởᰁࡢ࣐ࢵࣆࣥ
ࢢࡀྍ⬟࡛࠶ࡿࠋ
ճࢧ࣮࣋࢖࣓࣮ࢱ࣮ࡸࢫ᳨࣑ࣖᰝࡢ⾲㠃ởᰁࡔࡅ࡛࡞ࡃࠊ㛗ᮇ㛫 ᐃࡍࡿࡇ࡜࡛ෆ㒊ࡢởᰁ㸦ᨺᑕ໬㸧ࡀࢃ࠿ࡿࠋ࡜ࡋ࡚⥺※ࡢሙᡤࡀ≉ᐃ࡛ࡁ࡞࠸ࡢ࡟ᑐࡋ࡚ࠊࢫ࣌

㸱㸬⿦⨨ࡢసᡂ
25 mm ࡢ࢔࣑ࣝࣇࣞ
࣮࣒ࢆ㦵᱁࡜ࡋ࡚ᶓ
㍈࡟✌ാ㊥㞳 200 mmࠊ⦪㍈࡟✌ാ㊥㞳 500
mm ࡢ࢔ࢡࢳ࢚࣮ࣗࢱ
࣮ࠊ⦪㍈ࡢ✌ാ㒊ศ࡟CsI ᳨ฟჾࢆྲྀࡾ௜ࡅ
ࡓࠋ᳨ฟჾࡢど㔝ゅࢆᑠࡉࡃࡋࠊởᰁ఩⨨ࢆ≉ᐃࡋࡸࡍࡃࡍࡿࡓ
ࡵ࡟᳨ฟჾࡢഃ㠃࡟
ࡣཌࡉ 0.5mm ࡢ㖄ࢸ࣮ࣉࢆ 20 ᅇᕳࡁࠊྜ
ィ 10mm ࡢ㖄࡛ࢥ࣓ࣜ

Fig. 2 ࡟ሷ໬࣒࢝ࣜ࢘ 25.1g(40K ⣙ 400 Bq)ࢆ᳨ฟჾ
࠿ࡽ⣙ 10 cm ࡢ㊥㞳࡟⨨࠸࡚ᐃࢆ⾜ࡗࡓ⤖ᯝࢆ♧ࡍࠋ㧗ࡉ᪉ྥ 1~500 mm ࡢ⠊ᅖࢆ 5 ศ๭ࠊᅇ㌿᪉ྥ
0~360rࢆ 8 ศ๭ࠊ1 Ⅼᙜࡓࡾ 1 ᫬㛫ࡢᐃࢆ⾜ࡗࡓࠋ

ࢡࢺࣝゎᯒ࡛ 40K ࡢ 1461 KeV ࡢࣆ࣮ࢡ࡟ ROI ࢆ࠿ࡅࡓ᪉ࡣᕥୖ࡟⥺※ࡀ࠶ࡿࡇ࡜ࡀᐜ᫆࡟≉ᐃ࡛ࡁࡿࠋ

Fig. 2 40K-400 Bq ㊥㞳 5 cm ࡛ࡢᙉᗘศᕸᅗ
ᕥ㸸ࢫ࣌ࢡࢺࣝゎᯒࠊྑ㸸࢝࢘ࣥࢺ࣮ࣞࢺゎᯒ㸳㸬 ࡲ࡜ࡵ
ඛࡢ౛࡛♧ࡋࡓ 40K ࡣ 1 ᮏࡢȚ⥺ࡋ࠿ᨺฟࡏࡎࠊ
ᨺฟ⋡ 10.8%࡜ప࠸ࡓࡵ 2 ࢖ࣥࢳࡢ GM ⟶࡛⾲㠃ࢧ࣮࣋࢖ࡋ࡚ࡶởᰁࢆ᳨▱࡛ࡁ࡞࠸࡛ࣞ࣋ࣝ࠶ࡿࠋ௒
ᅇ㛤Ⓨࡋࡓ⿦⨨࡛ࡣ 10cm 㞳ࡋࡓ≧ែ࡛ࡶ᳨▱࡛ࡁࡿࡇ࡜ࡀ☜ㄆ࡛ࡁࡓࠋࡇࢀࡣ⿦⨨ࡢ≉ᚩ࡛࠶ࡿ㛗᫬㛫⮬ື ᐃ࡜ࢫ࣌ࢡࢺࣝゎᯒࡀ⾜࠼ࡿ࡜࠸࠺ࡇ࡜ࡀ
せᅉ࡛࠶ࡿࠋᐇ㝿ࡢởᰁࡣ⾲㠃ࡔࡅ࡛࡞ࡃෆ㒊ࡢởᰁࡶ⪃࠼ࡽࢀࠊ⮬ᕫ㐽ⶸࡢᙳ㡪ࡶ⪃៖ࡍࡿᚲせࡀ࠶ࡿࠋ᭱⤊ⓗ࡟ࡣ࠶ࡿ⛬ᗘࡢࣔࢹࣝࢣ࣮ࢫࢆ᝿ᐃࡋ࡚
ᨺᑕ⬟ࢆᐃ㔞࡛ࡁࡿࡼ࠺࡟ࡋࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ

Fig. 1 ⿦⨨ࡢእほThe development of radioactive contamination inspection machineRyo Okumura Tatsuya Yamada
rokumura@rri.kyoto-u.ac.jp

㻙 㻟㻞㻌㻙

㻔㻼㻝㻥㻕 ⁐ᾮ࢚࢔ࣟࢰࣝ࡬ࡢ᰾ศ⿣⏕ᡂ≀ࡢ௜╔ᣲື࡟࠾ࡅࡿ⁐㉁ࡢᙳ㡪㸦ி኱㝔ᕤࠊி኱ཎᏊ⅔ 1㸧 ࠐす⃝భ௓ࠊ㧗ᐑᖾ୍ 1ࠊ㛵ᮏಇ 1ࠊἈ㞝୍ 1ࠊ኱ᵳ໅ 1
1. ࡣࡌࡵ࡟ : ⚟ᓥ➨୍ཎᏊຊⓎ㟁ᡤࡢ஦ᨾ࡟ࡼࡾ

FP ࢆᤕ㞟ࡋࠊྠᵝࡢཎᏊ⅔ෆࡢ᰾ศ⿣⏕ᡂ≀࡞࡝ࡢᨺᑕᛶ≀㉁ࡀ⎔ቃ୰⥺ࢫ࣌ࢡࢺ࣓ࣟࢺ࣮ࣜ࡟ࡼࡾᚓࡽࢀࡓ 104Tc (T1/2࡟኱㔞࡟ᨺฟࡉࢀࡓࠋ୰࡛ࡶᨺᑕᛶ࢚࢔ࣟࢰࣝ࡜ࡋ

18.3 min)ࡢィᩘ⋡ࡢẚࢆࡶ࡜࡟ࠊ104Tc ࡀ⁐ᾮ࢚࢔࡚ࠊ኱Ẽ୰࡟ᨺฟࡉࢀࡓ≀㉁ࡣᗈ⠊ᅖ࡟ᣑᩓࡋࡓࠋ

ࣟࢰࣝ࡟௜╔ࡋࡓ๭ྜ(௜╔⋡)ࢆ⟬ฟࡋࡓࠋࡲࡓࠊศ

ࡇࢀࡽࡢᨺᑕᛶ≀㉁ࡢ⎔ቃ୰࡛ࡢ⛣⾜ࢆ᥎ࡍࡿࡓ⣭ࡉࢀࡓ࢚࢔ࣟࢰࣝ⢏Ꮚࡢ඲⾲㠃✚ࢆぢ✚ࡶࡿࡓࡵࡵ࡟ࡣࠊ㐠ࡧᡭ࡜࡞ࡗࡓ࢚࢔ࣟࢰࣝࡢ⢏ᚄࡸ≀⌮ⓗࠊ࡟ࠊศ⣭๓ࡢ⁐ᾮ࢚࢔ࢰࣟࣝࡢྛ⢏ᚄ࡟࠾ࡅࡿಶᩘ

໬Ꮫⓗ≉ᛶ࡞࡝࡟㛵ࡍࡿ▱ぢࡀᚲせ࡛࠶ࡿࠋᡃࠎࡣࠊ

⃰ᗘࢆ SMPS (Scanning Mobility Particle Sizer;

ཎᏊ⅔ෆ࡛⏕ᡂࡋࡓ࡜⪃࠼ࡽࢀࡿᨺᑕᛶ࢚࢔ࣟࢰࣝ

TSI ♫ 3936)ࢆ⏝࠸࡚ ᐃࡋࡓࠋᐃࢆ⾜ࡗࡓࠋࡑࢀࡒࢀࡢ γࡢ࠺ࡕ⁐ᾮ≧ࡢ࢚࢔ࣟࢰࣝ࡟╔┠ࡋࠊࡑࡢ⏕ᡂᶵᵓࢆゎ᫂ࡍࡿࡇ࡜࡟ࡼࡗ࡚ࠊᨺฟࡉࢀࡓᨺᑕᛶ࢚࢔ࣟ

3. ⤖ᯝ : ⃰ᗘࡀ 0.1 wt%࡜ 0.4 wt%ࡢሷ໬ࢼࢺࣜ࢘

ࢰࣝࡢᛶ≧ࢆ᥎

࣒Ỉ⁐ᾮ࠿ࡽ⏕ᡂࡍࡿ⁐ᾮ࢚࢔ࣟࢰࣝࢆ⏝࠸࡚ᐇ㦂ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡢ࡛ࡣ࡞࠸࠿࡜

ࢆ⾜ࡗࡓ㝿ࡢࠊ࢚࢔ࣟࢰࣝ⢏Ꮚࡢ඲⾲㠃✚࡜ FP ࡢ⪃࠼ࡓࠋࡇࢀࡲ࡛ࡢ◊✲࡟࠾࠸࡚ࠊ⁐ᾮ࢚࢔ࣟࢰࣝ࡬᰾ศ

࢚࢔ࣟࢰࣝ⢏Ꮚ࡬ࡢ௜╔⋡ࡢ┦㛵ࢆ Fig. 1 ࡟♧ࡍࠋ⿣⏕ᡂ≀ࡀ௜╔ࡍࡿࡇ࡜࡟ࡼࡿᨺᑕᛶ࢚࢔ࣟࢰࣝࡢ

࢚࢔ࣟࢰࣝ⢏Ꮚࡢ඲⾲㠃✚ࡢ㡿ᇦࡀ␗࡞ࡿࡓࡵ┤᥋⏕ᡂ㐣⛬࡟࠾࠸࡚ࠊᗄఱᏛⓗ࡞⾪✺࡟ࡼࡿ⏕ᡂ㐣⛬ࡢẚ㍑ࡣ࡛ࡁ࡞࠸ࡀࠊ⁐ᾮࡢ⃰ᗘࢆኚ໬ࡉࡏࡿࡇ࡜

࡟ຍ࠼࡚⁐ᾮ࢚࢔ࣟࢰࣝࡢᡂศࡢ㐪࠸ࡀᙳ㡪ࡍࡿ㐣࡟ࡼࡾ௜╔⋡ࡀ␗࡞ࡿഴྥࡀぢࡽࢀࡓࠋࡘࡲࡾࠊ104Tc⛬ࡀᏑᅾࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓ [1]ࠋࡑࡇ࡛ᮏ◊ࡢ⁐ᾮ࢚࢔ࣟࢰࣝ࡬ࡢ௜╔ᣲື࡟ࡣࠊ⁐ᾮ⃰ᗘ౫Ꮡ✲࡛ࡣࠊ⁐ᾮ࢚࢔ࣟࢰࣝ࡟ྵࡲࢀࡿ⁐㉁ࡢ✀㢮ࡸ⃰ᛶࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ

ᗘࡀᨺᑕᛶ࢚࢔ࣟࢰࣝࡢ⏕ᡂ㐣⛬࡟୚࠼ࡿᙳ㡪ࢆᐃ

Ⓨ⾲࡟࠾࠸࡚ࡣࠊ␗࡞ࡿ✀㢮ࡢ⁐㉁㛫࡛ࡢẚ㍑ࡶ

㔞ⓗ࡟᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚ᐇ㦂ࢆ⾜ࡗࡓࠋ⾜࠸ࠊᨺᑕᛶ࢚࢔ࣟࢰࣝࡢ⏕ᡂ㐣⛬࡟࠾ࡅࡿ⁐㉁ࡢ
ᙳ㡪࡟ࡘ࠸࡚⪃ᐹࢆ⾜࠺ࠋ

2. ᐇ㦂 : ⁐ᾮ࢚࢔ࣟࢰࣝࡢⓎ⏕࡟ࡣ࢔ࢺ࣐࢖ࢨ࣮
⮯໬ࢼࢺ࣒ࣜ࢘ࠊࣚ࢘໬ࢼࢺ࣒ࣜ࢘ࠊሷ໬ࢭࢩ࣒࢘
ࡢ 4 ✀㢮ࢆ⏝࠸ࡓࠋⓎ⏕ࡉࡏࡓ࢚࢔ࣟࢰࣝࡣ DMA(Differential Mobility Analyzer)࡟ࡼࡗ࡚ศ⣭ࡍࡿࡇ࡜࡟ࡼࡾ༢ศᩓ࢚࢔ࣟࢰࣝ࡜ࡋࠊ⮬Ⓨ᰾ศ⿣᰾✀࡛࠶ࡿ 252Cf ⥺※(1 MBq)ࢆタ⨨ࡋࡓࢳ࢙ࣥࣂ࣮ෆ࡟
ᑟධࡋࡓࠋࢳ࢙ࣥࣂ࣮ෆ࡛ࡣ 252Cf ࠿ࡽᨺฟࡉࢀࡿ
᰾ศ⿣⏕ᡂ≀(FP)ࡀ⁐ᾮ࢚࢔ࣟࢰࣝ⢏Ꮚ࡟௜╔ࡋࠊᨺᑕᛶ࢚࢔ࣟࢰࣝࢆ⏕ᡂࡍࡿࠋ⏕ᡂࡋࡓᨺᑕᛶ࢚࢔
ࣟࢰࣝࢆ࣏࣮ࣜ࢝࣎ࢿ࣮ࢺ〇ࣇ࢕ࣝࢱ࣮(ᮾὒℐ⣬♫〇ࠊᏍᚄ㸸0.2 μm)࡟࡚ 30 ศ㛫ᤕ㞟ࡋࠊGe ༙ᑟయ᳨ฟჾࢆ⏝࠸࡚ γ ⥺ࢫ࣌ࢡࢺ࣓ࣟࢺ࣮ࣜࢆ⾜ࡗࡓࠋ40
Attachment ratio [%]㸦TSI ♫ 3076㸧ࢆ⏝࠸ࡓࠋ⁐㉁࡟ࡣሷ໬ࢼࢺ࣒ࣜ࢘ࠊ

30

0.1 wt%
0.4 wt%

20
10
0
0

0.1
0.2
0.3
2
Total surface area [cm ]0.4

Fig 1. Attachment ratio of (104Tc) to sodium chloride
solution aerosol as a function of the total surface area of
the aerosol particles.

ࡲࡓࠊ252Cf ⥺※ࡢ┤ୖ࡟ࢢࣜࢫࢆሬᕸࡋࡓࢭ࣮ࣝࣟ

ཧ⪃ᩥ⊩[1] K. Takamiya et al., J. Radioanal. Nucl. Chem. 307

ࢫࢁ⣬ࢆタ⨨ࡋࠊ252Cf ⥺※࠿ࡽᨺฟࡉࢀࡿࡍ࡭࡚ࡢ

(2016) 2227-2230.

Effect of solute on attachment behavior of fission products to solution aerosol
Yusuke Nishizawa, Koichi Takamiya, Shun Sekimoto, Yuichi Oki, Tsutomu Ohtsuki
nishizawa.yusuke.77u@st.kyoto-u.ac.jp

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㻔㻼㻞㻜㻕 ࣄࢺ⾑Ύ୰ࡢ D-࢔࣑ࣀ㓟ྵ᭷࣌ࣉࢳࢻࡢ᥈⣴ཬࡧྠᐃ㸦ி኱⌮ࠊி኱ཎᏊ⅔ 㸧‫ۑ‬+D6HRQJPLQࠊ⸨஭⣖Ꮚ [⥴ㄽ] ㏻ᖖࠊ⏕࿨యࢆᵓᡂࡍࡿ࢔࣑ࣀ㓟ࡣ L ᆺ࡛࠶ࡿࡀࠊ㏆ᖺࠊຍ㱋࡟ᛂࡌ࡚ࠊD ᆺࡢ࢔࣑ࣀ㓟ṧᇶࡀࢱࣥࣃࢡ㉁୰࡟⵳✚ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
≉࡟ࠊ࢔ࢫࣃࣛࢠࣥ㓟(L-Ș-Asp)ṧᇶࡢ␗ᛶయ(L-ș-,
D-Ș-, D-ș-Asp)ࡀࠊⓑෆ㞀ࡸ࢔ࣝࢶࣁ࢖࣐࣮⑓࡞࡝ࠊ
ᵝࠎ࡞ຍ㱋ᛶ⑌ᝈࡢཎᅉࢱࣥࣃࢡ㉁୰࡛ぢࡘ࠿ࡗ࡚࠸ࡿࠋࡲࡓ㏆ᖺࠊศᯒ໬Ꮫᢏ⾡ࡢ㐍Ṍ࡟ࡼࡾ࢔࣑ࣀ
㓟㸯ṧᇶࡈ࡜ࡢಟ㣭ࢆศᯒ࡛ࡁࡿࡼ࠺࡟࡞ࡾࠊࢱࣥ
ࣃࢡ㉁୰ࡢ࢔࣑ࣀ㓟ṧᇶࡣ㓟໬ࠊ⬺࢔࣑ࢻ໬ࠊ␗ᛶ
໬࡞࡝ࠊᵝࠎ࡞ಟ㣭ࢆཷࡅ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞
ࡗ࡚ࡁࡓࠋ୍᪉ࠊ⾑Ύ୰࡟ࡣᵝࠎ࡞⺮ⓑ㉁ཬࡧ࣌ࣉ
ࢳࢻࡀᏑᅾࡋࠊࡑࡢ୰࡛ࡶ≉࡟పศᏊ㔞ࡢ⺮ⓑ㉁ཬ
ࡧ࣌ࣉࢳࢻࢆྛ✀⑌ᝈࡢデ᩿࡟฼⏝ࡍࡿࡓࡵࡢ◊✲ࡀ㐍ࡵࡽࢀ࡚࠸ࡿࠋࡑࢀࡽ࣌ࣉࢳࢻ୰࡛ࡣ␗ᛶ໬ࡋ
࡚࠸ࡿ࣌ࣉࢳࢻࡀᏑᅾࡍࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࡢ࡛ࠊ
ᮏᐇ㦂࡛ࡣࣄࢺ⾑ᾮ୰ࡢ D-࢔࣑ࣀ㓟ྵ᭷࣌ࣉࢳࢻࡢ
᥈⣴ཬࡧࡑࡢྠᐃࢆ⾜ࡗࡓࠋ>᪉ἲ@ ᐇ㦂ࡢᴫせࢆᅗ㸯࡟♧ࡍࠋࣄࢺ⾑Ύ࡟࢚ࢱࣀ࣮ࣝỿ㝆ἲࢆࡍࡿࡇ࡜࡛ࠊࢱࣥࣃࢡ㉁ࢆ㝖ཤࡋࠊ࣌ࣉࢳࢻࡢࡳࡢศᯒࢆ⾜ࡗࡓࠋ࣌ࣉࢳࢻࡣ㏫┦ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮ 53+3/& ࡛ศ㞳ࡋࠊ᭦࡟ຍỈศゎࡋࡓࠋᚓࡽࢀࡓ࢔࣑ࣀ㓟ࢆㄏᑟయ໬ࡋ 53+3/& ࡛࢔࣑ࣀ㓟ࡢගᏛ␗ᛶయศᯒࢆ⾜࠸ࠊࡑࢀࡒࢀࡢ '/ ẚࢆồࡵࡓࠋࡲࡓࠊᾮయࢡ࣐ࣟࢺࢢࣛࣇ࣮㉁㔞ศᯒ⿦⨨/&06 ࡛ $VS ␗ᛶయࢆྵࡴ࣌ࣉࢳࢻࢆ᳨ฟࡋࠊࡑࡢ
0606 ᝟ሗ࠿ࡽ࣌ࣉࢳࢻࡢྠᐃࢆ⾜ࡗࡓࠋᅗ㸯㸬ᐇ㦂ࡢᴫせIdentification of D-amino acid-containing peptides in human serum
Ha Seongmin, Noriko Fujii
ha.seongmin.47n@st.kyoto-u.ac.jp

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Fig.1 Removal of tritium from water to the contact timewith magnesia.
jå¬Î[1]H.Koyanaka &H.Miyatake, Separation Science Technology, 50 (2015) 2142-2145.
[2] »ËÛ/, Íč 2016-135839 (2016).

Possible removal of tritium from the water by hydrated reaction of magnesia with water including tritium
Hideo Hashizume, Akihiro Uehara, Satoshi Fukutani, Kazuko Fujii, Toshihiro Ando
HASHIZUME.Hideo@nims.go.jp

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Fig. 1. Protocol of calculation of distance (dist) anddensity () at any position (x,y,z)āþË¢Ăv 2  D/H 2I<D6<,Ö¹ävan der Waals Øø (æ÷@H:<1D?
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(D2O Ë) [4],P}úµ u;K9úg}± JRR-3  BIX-3 uÝ(JAEA, ¯)[5]jö(aÜÏ 1.8Åj³ 72.1%(D2O Ë)72.5%(H2O Ë))D2O ËH2O Ë;K9,µÀõ D/H 2I<D6<­')ñ«È/é«Èg}(HD g}"Råg})m
,× Ê§í,(R = 19.7%, Rfree = 22.1)[1]
ËPXYÍ(x,y,z) *Ö¹äØø(æ÷ dist(x,y,z)(x,y,z),v 1 ¾­ÝÅÝÅµ@H1DC Python3 ÞëÝÅìs%Lð GFortran ,\µ * P}B:@
nCNS[6]
ÝÅ¥ßÄ CCP4[7],\µ *ÝÅ, D2O ËP}B:@H2O ËP}B:@D/H 2I<D6<B:@ ×

Fig. 2. Density of D/H contrast map. The horizontal
axis represents distance from protein surface.
hÎ²[1] T. Chatake & S. Fujiwara, Acta Cryst. D72 (2016)
59–70.
[2] A.A. Kossiakoff et al., Proteins 12 (1992) 223–236.
[3] R. Berisio et al., Acta Cryst. D58 (2002) 441–450.
[4] T. Chatake, S. Fujiwara, Y. Morimoto, KURRI Progress Report 2009, (2010) 164.
[5] I. Tanaka et al., J. Appl. Cryst. 35 (2002) 34–40.
[6] P.D. Adams, et al., Acta Cryst. D65 (2009) 567–573.
[7] M. D. Winn, et al. Acta Cryst. D67 (2011) 235–242.

D/H contrast method in neutron protein crystallography toward revealing hydration structures of macromolecules
Toshiyuki Chatake, Satoru Fujiwara
chatake@rri.kyoto-u.ac.jp

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23

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ăīĜ ìí/Øà³GAMV K2 (MK-7)Ŋª·#Ł1/GAMV K2 %~g%ēà³ ăīĜ%Øà³$GAMV K2 2íì/mġöü#,.MK-7 %rĽĂ 10 Y$ŋÔĤg/sÀ/ " -$è³è#ÐĴµ%Ö!0"cå#ĨČ0
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Ĝû% Bacillus subtilis natto Miyagino strain (BSNM)
ûĜ2 2 ¿JT8SBOW¬PBS(-)¦ļ(¿ÆĞ¢¾Òß)#JTWD4
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ăīĜ ìí/Øà³GAMV K2(MK-7)
}ĝù$ĕãċÝŏrĽŕYŐ2î
ł57Vbº:ULE;QI4W2(DEAE)3
ġMK-7 $~ń2ġcåÃćĀģ$<SäĶ:ULE;QI4W(Sephacryl S-300)2
ġĳ+ (12 Áŀ¬)#zón¼^(DLS)Þ2ġ
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Fig.1 Result of colonization of BNSM (left) andreproductive experiment at RII (right).
ăīĜ ìí/Øà³GAMV K2(MK-7)
 2 # DLS #,.­-0 MK-7 $¼^n©¨ÿ¨r¥2ø4 /HW:$ MK-7 #°
/HW:% 2 ðô ,' 3 ðô/2 ðô$
HW:% MK-7 ~g$2ø .ÿ« 27
 /X¾3 ðô$HW:%ÿ« 478 .
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Fig.2 Particle size distribution of the purified MK-7
in dynamic light scattering experiment.

Structural Properties of MK-7 and gamma-ray resistance of Bacillus subtilis natto
Yasuhide Yanagisawa, Arisa Takane, Tatsumi Adachi, Toshiyuki Chatake, Takeshi Saito, Rintaro Inoue, Masaaki Sugiyama, Tatsuo
Matsuo, Satoru Fujiwara, Tadanori Ohsugi, Hiroyuki Sumi
yyanagisawa@cis.ac.jp

㻙 㻟㻤㻌㻙

㻔㻼㻞㻡㻕 < >éíkėĘµ­úě)ÎÍÄñÿuġUnÏć¡ Ģċâ³¯ĔÁü}ÆÀĐࠊĠîM

1. ë Ā
¾ºđv¨jđ )/=H2L¦YË ģ§©^«b ēþ)Ĥμ b ģ(a)Fe(6nm)
MôÎÍÄ|ÄÊhd,h )S&(ø+*)Ĥ ģ!$hÅ&(Ęµúě,<>éík)SģÊhd,h )SÐģb sð)Ğê·,Ĥ[1] ģ<>éí ²)ğ¹¿ĚÎÍÄaęğ ÛT[×Ċy)RÌ ģR,ûW):L7 '*  Ĥ´Üá ģĜ,O )y)úěæ,¼gYË).0JALE6@87ÅġIBSĢ&(<>
éíĖñ,[ýģĄ­¼úě{Zĥ{Zģ{(b)Fe(60nm)
ZĥÈZØěă] sðpÓÅ&(<>éíµ­úě)ÎÍÄñÿ,Ą$Ĥ
2.  Ğ ® Å\Ąµ ç 99.99%ç Fe ,7L58;× ģ
Si &"1G6|¶N Fe ÷ññ,øĤģFe ññm,k)&(ģåġ¹¿ĚetĢ bsð)Ĥñm t b ģñ°ę&(bģ6, 60 nm  Fe ñ,[ýĤpÓÌ
Cu-K X ì,× ø ģ[ý Fe
Fig. 1 X-ray reflectivity of pure Fe film. Objectived
ññmă]ģ#ģÎÍÄ,~ÑÌ
film thicknesses are (a) 6 nm and (b) 60 nm, respec)Äñă],øĤ
tively. Red solid line is a result of profile fitting using
3. ê · K ï bi-layer model.
Fig.1
IBS &([ýç Fe ÷ñġ6 &"60 nmĢ X ìpÓÌ ê·)ĤzQĉì
2 F:HB-89-J4ê·,Þ(ģÃČÙõĞê·,`Ô ) a)ĤF:Hāä 'ģIBS &(?H3Ď 
 Fe ñ ý[ ) a )Ĥ#ģPĄ­m 2 nm àĒkñ%Þw*ĤNď Fe ñģEster Ä,~ģpÓ@
7LJk,ą¸Ĥê·ģÄ,~pÓ ËģpÓ£j Ç)ÔĈ ÿ
*ģÄ,¢q ~c@7LJMòġFig.2ĢĤÔĈ 60 nm ñ&( 6 nm ñĝöÿ* (ģê±åèkġ¹¿ĚĕĢ ÔĈĜ )¤*)Ĥ
Fig.2 X-ray reflectivity of 6 nm Fe film before and* ģÄñ ÿ*,Þw)ê·
after soaked in Ester oil. X-ray reflectivity of soaked) ģÄúěD3IkĊy )sample after washing oil with ethanol is also shown.
sð%Â* (ģV»Ă þ)Ĥ
Note that same sample was used throughout the exĆč
periment.
´ÜáMđ ģ¯´ėĘlX ã 24 xėĘÜá
oï¬Ò£óiģ'"ß¡ù£ó¾½(JST)Ö_f[1] Y. Todaka, K. Toda, M. Horii, M. Umemoto: Tet|Ý|ÚÜáCI4GEª¥,rø+*%su-To-Hagane, 101(2015) 530.
(ģÉÕ)Ć,ú).


Toward observation of lubricant film formed on nano-structured steelNozomu Adachi, Masahiro Hino, Yojiro Oba, Yoshikazu Todaka
QDGDFKL#UULN\RWRXDFMS㻙 㻟㻥㻌㻙

㻔㻼㻞㻢㻕 J-PARC MLF BL06 ࡟࠾ࡅࡿ TOF-MIEZE ᆺࢫࣆ࢚ࣥࢥ࣮ศගἲ࡟ࡘ࠸࡚ࡢ◊✲㸦ி኱ཎᏊ⅔㸪KEK ≀ᵓ◊ 1㸧‫ۑ‬ᑠ⏣㐩㑻㸪᪥㔝ṇ⿱㸪ᕝ➃♸ྖ㸪㐲⸨ோ 1㸪ᒣ⏣ᝅྐ 1㸪℩ᡞ⚽⣖ 1㸯㸬ࡣࡌࡵ࡟㸸୰ᛶᏊࢫࣆ࢚ࣥࢥ࣮ἲࡣ㸪୰ᛶᏊࢫࣆࣥᅛ᭷≧ែ㛫ࡢ఩┦ᕪࢆ฼⏝ࡋ࡚㸪ヨᩱ࡛ࡢ㠀ᙎᛶᩓ஘࡟ࡼࡿ୰ᛶᏊࡢࢃࡎ࠿࡞㏿ᗘኚ໬ࢆᶆ㆑ࡍࡿ
୰ᛶᏊᩓ஘ศගἲ࡛࠶ࡿ㸬Ⲉᇛ┴ᮾᾏᮧ࡟࠶ࡿ Japan
Proton Accelerator Research Complex (J-PARC) ࡢ≀㉁࣭⏕࿨⛉Ꮫᐇ㦂᪋タ (Material and Life Science
Experimental Facility; MLF) ࡢ᭷ࡍࡿࣅ࣮࣒ࣛ࢖ࣥࡢ
୍ ࡘ BL06 ࡟ ࡣ ୰ ᛶ Ꮚ ඹ 㬆 ࢫ ࣆ ࣥ ࢚ ࢥ ࣮ ศ ග ჾ⩌ ”VIN ROSE” ࡀᩚഛ୰࡛࠶ࡿ㸬㏻ᖖࢫࣆ࢚ࣥࢥ࣮ศගჾ࡟࠾࠸࡚ࡣ㸪㠀ᙎᛶᩓ஘ࡀ㉳ࡇࡽ࡞࠸ሙྜ㸪ࢫࣆࣥ᧯సࢆ⤒ࡓᚋ࡟ࡍ࡭࡚ࡢ
Ἴ㛗࡟ᑐࡋ࡚ධᑕࣅ࣮࣒ࡢ೫ᴟᗘࡀ෌⌧ࡉࢀࡿࡼ࠺
࡟⿦⨨඲యࡀㄪᩚࡉࢀࡿᚲせࡀ࠶ࡿ㸬ඹ㬆ࢫࣆ࢚ࣥࢥ࣮ἲࡢ୍✀࡛࠶ࡿ Modulation of Intensity by Zero
Effort (MIEZE) ἲ [1] ࡛ࡣ㸪ࡇࡢ᮲௳ࡣ MIEZE ᮲௳࡜࿧ࡤࢀ㸪ᵓᡂせ⣲ࡢ఩⨨㛵ಀ࡟ཝࡋ࠸ไ⣙ࡀㄢࡏࡽࢀࡿ㸬ࡋ࠿ࡋ㸪ࣃࣝࢫ୰ᛶᏊࢆ⏝࠸ࡓ㣕⾜᫬㛫(TOF) ἲ࡜⤌ࡳྜࢃࡏࡓ MIEZE ἲ (TOF-MIEZE)ࡣ㸪㓄⨨ࡀ MIEZE ᮲௳࠿ࡽࡎࢀࡓሙྜ࡛ࡶࢩࢢࢼࣝ
ࡢࢥࣥࢺࣛࢫࢺࡣ࡯࡜ࢇ࡝ῶᑡࡏࡎ㸪ࡎࢀࡢᙳ㡪ࡣᐇຠ᣺ືᩘࡢࢩࣇࢺ࡟⌧ࢀࡿ࡜࠸࠺≉ᚩࢆᣢࡗ࡚࠸
ࡿ㸬ࡇࡢ TOF-MIEZE ࢩࢢࢼࣝࡢ≉ᚩࢆᐇドࡍࡿࡓࡵ㸪ᡃࠎࡣ୰ᛶᏊࣅ࣮࣒ࡢࣃࣝࢫᖜࢆ⪃៖ࡋࡓ
TOF-MIEZE ἲࡢᐃᘧ໬ࢆ⾜࠸ [2]㸪J-PARC MLF
BL06 ࡟࠾࠸࡚ᐇ㦂ࢆ⾜ࡗࡓ㸬㸰㸬ᐇ㦂⤖ᯝ㸸ᅗ 1 ࡟ඹ㬆ࢫࣆࣥࣇࣜࢵࣃ࣮ࡢ㓄⨨ࢆ π/2 (200 kHz)—π/2 (400 kHz) ࡜ࡋ࡚ MIEZE ᮲௳࡛ᚓࡽࢀࡓᐇຠ᣺ືᩘ 200 kHz ࡢ TOF-MIEZE ࢩࢢࢼࣝࢆ♧ࡍ㸬ᅗ 1 (a) ࡣ࿘ᮇ 12.5Hz ࡢ TOF ࣇ࣮࣒ࣞ඲య࡛ࡢ⾲♧㸬(b), (c), (d) ࡣ࠸ࡃࡘ࠿ࡢ TOF ⠊ᅖ
(50μs) ࢆᣑ኱ࡋࡓᅗ࡛࠶ࡿ㸬㓄⨨ࡀ MIEZE ᮲௳࠿ࡽࡎࢀࡓሙྜ࡟࠾ࡅࡿ TOF-MIEZE ࢩࢢࢼࣝࡢ≉ᚩࢆㄪ࡭ࡿࡓࡵ࡟㸪᳨ฟჾࡢ఩⨨ࢆពᅗⓗ࡟ MIEZE ᮲௳࠿ ࡽ 160 mm ୗ ὶ ഃ࡟ࡎࡽࡋࡓ㸬ࡇࡢሙྜ࡛ࡶ
MIEZE ࡢ᣺ືࡣほ ࡉࢀ㸪ࢩࢢࢼࣝࢆࣇ࣮࢚ࣜኚ᥮
ࡍࡿ࡜ᅗ 2 (a) ࡢᐇ⥺࡛♧ࡉࢀࡿࣃ࣮࣡ࢫ࣌ࢡࢺࣝ
ࡀᚓࡽࢀࡓ㸬MIEZE ᮲௳ (on-MIEZE) ࡢ 200 kHz㸦Ⅼ⥺㸧࠿ࡽࢩࣇࢺࡋࡓ 198.5 kHz ࡢ఩⨨࡟᫂░࡞ࣆ࣮ࢡࡀほ ࡉࢀࡓ㸬ࡉࡽ࡟␗࡞ࡿ᳨ฟჾࡢኚ఩࡟ᑐࡋ
࡚ᐇຠ᣺ືᩘࡢࢩࣇࢺࢆࣉࣟࢵࢺࡋࡓࡶࡢࡀᅗ 2 (b)࡛࠶ࡿ㸬ᅗ 2 (b) ࡢᅇᖐ┤⥺ࡢഴࡁࡣ㸪ኚ఩࡟ᑐࡍࡿ
ᐇຠ᣺ືᩘࢩࣇࢺࡢኚ໬⋡ࢆ⾲ࡋ࡚࠾ࡾ㸪ᐃᘧ໬࠿ࡽண᝿ࡉࢀࡿኚ໬⋡࡜ࡼ࠸୍⮴ࢆ♧ࡋࡓ㸬㸱㸬ࡲ࡜ࡵ㸸ࢩ࣮ࣙࢺࣃࣝࢫࣅ࣮࣒ࢆ⏝࠸ࡓ
TOF-MIEZE ἲࡢ≉ᚩࢆᐇドࡋࡓ㸬ࡇࡢ≉ᚩࡣ⿦⨨ㄪᩚ࡟࠾࠸࡚౽฼࡞ࡔࡅ࡛࡞ࡃ㸪‽ᙎᛶᩓ஘ ᐃࡢࢹ࣮ࢱゎᯒ࡟࠾࠸࡚ࡶ฼⏝࡛ࡁࡿ࡜ᮇᚅࡉࢀࡿ㸬

Fig. 1. (a) TOF-MIEZE spin echo signal with a frequency of 200 kHz observed at BL06. Enlarged
views in typical TOF ranges: (b) 25—25.05 ms, (c)35—35.05 ms, (d) 45—45.05 ms.

Fig. 2 (a) Power spectra obtained by Fourier transformation of TOF-MIEZE signals at on/off-MIEZE
condition. (b) Observed frequency shifts for various
displacements of the detector position.
ཧ⪃ᩥ⊩[1] R. Gähler et al., Physica B 180&181 (1992) 899-902.
[2] T. Oda et al., Rev. Sci. Instrm. 87 (2016) 1051.

Experimental study on TOF-MIEZE type neutron spin echo spectroscopy at BL06 at J-PARC/MLF
Tatsuro Oda, Masahiro Hino, Yuji Kawabata, Hitoshi Endo, Norifumi L. Yamada Hideki Setot_oda@rri.kyoto-u.ac.jp

㻙 㻠㻜㻌㻙

㻔㻼㻞㻣㻕 αቯቯኚ཯㊴᰾ 229mThࢆᤕ㞟ࡋࡓヨᩱ࠿ࡽࡢ┿✵⣸እග ᐃ㸦㜰኱㝔⌮ࠊி኱ཎᏊ⅔ 1ࠊᮾ໭኱㔠◊࣭኱Ὑ 2㸧‫ۑ‬Ᏻ⏣ຬ㍤ࠊ➟ᯇⰋᓫࠊ㔜Ἑඃ኱ࠊ㧘ᐑᖾ୍ 1ࠊ኱ᵳ໅ 1ࠊ୕㢌⫄᫂ 2ࠊ⠛ཎཌ㸯㸬ࡣࡌࡵ࡟㸸 ㉁㔞ᩘ 229 ࡢ Th ࡟ࡣ 7.8 r 0.5 eV ࡜࠸࠺㠀ᖖ࡟ప࠸ບ㉳࢚ࢿࣝࢠ࣮ࢆᣢࡘ᰾␗ᛶయ
229m
Th ࡀᏑᅾࡋࠊࡇࡢ್ࡣග࡛ࡣἼ㛗ࡀ⣙ 160 nm ࡢ┿✵⣸እග࡟┦ᙜࡍࡿ[1]ࠋ229mTh ࡣ୺࡟ෆ㒊㌿᥮ࡲࡓࡣ γ ⥺㑄⛣࡟ࡼࡗ࡚ቯኚࡍࡿ࡜⪃࠼ࡽࢀࡿࡀࠊບ
㉳࢚ࢿࣝࢠ࣮ࡀ໬Ꮫ⤖ྜ࡜ྠ⛬ᗘࡢ኱ࡁࡉ࡛࠶ࡿࡓ
ࡵ࡟ቯኚ⤒㊰ࡑࡢࡶࡢࡀ໬Ꮫ≧ែ࡟ࡼࡗ࡚ኚ໬ࡍࡿ
࡜࠸࠺㠀ᖖ࡟⯆࿡῝࠸⌧㇟ࡀண ࡉࢀ࡚࠸ࡿࠋࡇࡢ
⌧㇟ࡣᐇ㝿࡟ෆ㒊㌿᥮㟁Ꮚ ᐃ࡟ࡼࡿほ ࡟ࡼࡗ࡚♧၀ࡉࢀ࡚࠾ࡾ[2]ࠊ᭦࡟ 229mTh ࠿ࡽࡢගᏊ㸦γ ⥺㸧ࢆ᳨ฟࡍࡿࡇ࡜࡟ࡼࡾࠊ໬Ꮫ≧ែ࡟ࡼࡿ᰾ቯኚࡢኚ
໬ࢆࡼࡾ┤᥋ⓗ࡟ほ ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㐣ཤ࡟⾜ࢃࢀࡓගᏊ ᐃ࡛ࡣࠊMgF2 ୰࡟ 229mTh ࢆᤕ㞟ࡋࡓヨᩱ࠿ࡽ༙ῶᮇ⣙ 6 - 12 h ࡢῶ⾶ࡍࡿගᏊᨺฟᡂศࢆほ ࡋ࡚࠾ࡾࠊࡑࡢගᏊࡀ 229mTh ࡢ γ ⥺㑄⛣࡟ࡼࡿࡶࡢ࡛࠶ࡿ࡜ሗ࿌ࡋ࡚࠸ࡿ[3]ࠋࡋ࠿ࡋࠊࡇࡢගᏊࡢ
⏤᮶࡜ࡋ࡚ፉ᰾✀ࡢቯኚ࡟ࡼࡗ࡚Ⓨ⏕ࡋࡓࢳ࢙ࣞࣥ
ࢥࣇග࡛࠶ࡿྍ⬟ᛶࡶᣦ᦬ࡉࢀ࡚࠸ࡿࠋ
ᮏ◊✲࡛ࡣගᏊ ᐃ࡟ࡼࡗ࡚ 229mTh ࡢ⬺ບ㉳㐣⛬ࡢ໬Ꮫ≧ែ౫Ꮡᛶࢆほ ࡋࠊ229mTh ࡢቯኚ㐣⛬ࢆゎ᫂ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚࠸ࡿࠋ௒ᅇࡣࠊ཯㊴᰾ᤕ㞟⿦⨨[4]࡜ 233U ࡢ㟁╔ヨᩱࢆ⏝࠸࡚ 229mTh ࢆ MgF2 ୰ࡸ㔠ᒓ⾲㠃࡟ᤕ㞟ࡋࡓヨᩱࢆㄪ〇ࡋࠊගᏊ ᐃࢆ⾜ࡗࡓࡢ࡛ࠊࡑࡢ⤖ᯝ࡟ࡘ࠸࡚ሗ࿌ࡍࡿࠋ
233
㸰㸬ᐇ㦂㸸 ぶ᰾✀ U ࡢ α ቯኚ࡟క࠸཯㊴᰾࡜ࡋ࡚㣕ࡧࡔࡍ 229mTh ࢆ཯㊴᰾ᤕ㞟⿦⨨࡟ࡼࡗ࡚ᤕ㞟ࡋࡓࠋࡲࡎ 233U㸦୙⣧≀࡜ࡋ࡚ 232U ࢆ 0.7 ppm ྵࡴ㸧㟁╔ヨᩱ㸦φ30, 233U: 17.8 ± 0.3 μg/cm2㸧ࢆ཯㊴᰾ᤕ㞟⿦⨨ෆ࡟タ⨨ࡋࠊᤕ㞟ྎഃ࡟ MgF2 ࢆ⨨ࡁࠊ┿✵᮲௳ୗ࡛ 229mTh ࢆᤕ㞟ࡋࡓࠋࡲࡓࠊ232U ࡢፉ᰾✀࡛࠶ࡿ 228Th ࡢỿẊヨᩱ㸦φ18, ⣙ 300 Bq㸧ࢆ
233
U 㟁╔ヨᩱࡢ௦ࢃࡾ࡟⨨ࡃࡇ࡜࡛ 224Ra ➼ࡢ 233U
୰࡟୙⣧≀࡜ࡋ࡚ྵࡲࢀ࡚࠸ࡿ 232U ⣔ิ᰾✀ࡢࡳ
ࢆ MgF2 ୰࡟ᤕ㞟ࡋࡓヨᩱ࡟ࡘ࠸࡚ࡶㄪ〇ࡋࡓࠋ ḟ࡟ࠊ
཯㊴᰾ᤕ㞟⿦⨨୰࡟ 1 atm ࡢ࢞ࢫࢆᑟධࡋࠊ
࢞ࢫ୰࡛ 229mTh ࡢᤕ㞟ࢆ⾜ࡗࡓࠋࡇࡢ࡜ࡁ 229mTh ࡢᤕ㞟࡟ࡣ㖡ᯈࢆ⏝࠸ࡓࠋᑟධࡋࡓ࢞ࢫࡣ୙άᛶ࢞ࢫ
㸦N2 ࡲࡓࡣ He㸧ࡢࡳࡢሙྜ࡜୙άᛶ࢞ࢫ࡛⃰ࣇࢵ໬Ỉ⣲㓟ࢆࣂࣈࣜࣥࢢࡋࠊHF ࢞ࢫࢆᑟධࡋ࡚໬Ꮫ཯ᛂ
ࢆ㉳ࡇࡋࡘࡘ 229mTh ࢆᤕ㞟ࡋࡓሙྜ࡟ࡘ࠸࡚⾜ࡗࡓࠋගᏊ ᐃࡣ⣙ 10°C ࡟෭༷ࡋࡓග㟁Ꮚቑಸ⟶ࢆ⏝࠸
࡚ 4-10 eV ࡢ⠊ᅖ࡟ࡘ࠸࡚⾜ࡗࡓࠋ㸱㸬⤖ᯝ㸸 MgF2 ୰࡟ 229mTh ࢆᤕ㞟ࡋࡓヨᩱࡢගᏊᐃ⤖ᯝࢆ Fig.1 ࡟♧ࡍࠋඛ⾜◊✲[3]࡜ྠᵝ࡟ගᏊ
ᨺฟࡢῶ⾶ࡀほ ࡉࢀࡓࡀࠊࡇࢀࡣ୺࡟ 2 ᡂศࡢ༙ῶᮇᡂศ㸦༙ῶᮇ⣙ 40 min ࡜⣙ 10 h㸧ࢆྵࡴࡇ࡜ࡀ
ศ࠿ࡗࡓࠋࡲࡓࠊ228Th ỿẊࢆ⏝࠸࡚ㄪ〇ࡋࡓヨᩱ࠿ࡽࡶῶ⾶ࡍࡿගᏊᨺฟࡀほ ࡉࢀࡓࡀࠊ༙ῶᮇࡣ 1ᡂศ࡛࠶ࡾࠊ232U ⣔ิ᰾✀࡛࠶ࡿ 212Pb ࡢ༙ῶᮇ 10.64
h ࡟ࡼࡃ୍⮴ࡋࡓࠋࡲࡓࠊγ ⥺ࢫ࣌ࢡࢺࣝࡢ ᐃ⤖ᯝ࠿ࡽࡶ 212Pb ࡢῶ⾶ࡍࡿᵝᏊࡀほ ࡉࢀࡓࠋࡇࢀࡽࡢ
ᐃ⤖ᯝ࡜ 233, 232U ⣔ิ᰾✀ࡢ MgF2 ୰࡛ࡢཎᏊᩘࡢ
ኚ໬࡟ࡘ࠸࡚ࡢィ⟬⤖ᯝ࠿ࡽࠊ229mTh ヨᩱ࡟ᑐࡋ࡚ほ ࡉࢀࡓ 2 ࡘࡢῶ⾶ᡂศࢆ 233U ⣔ิࡢ 213Bi㸦45.59
min㸧࡜ 232U ⣔ิࡢ 212Pb㸦10.64 h㸧ࡢ༙ῶᮇࢆ⏝࠸࡚ࣇ࢕ࢵࢸ࢕ࣥࢢࢆ⾜ࡗࡓ(Fig.1 ࡢᐇ⥺)ࠋࣇ࢕ࢵࢸ
࢕ࣥࢢ᭤⥺ࡣ ᐃ⤖ᯝ࡜Ⰻ࠸୍⮴ࢆ♧ࡋࡓࡇ࡜࠿ࡽࠊ
MgF2 ୰࡟ 29mTh ࢆᤕ㞟ࡋࡓヨᩱ࠿ࡽほ ࡉࢀࡓගᏊ
ࡣ 229mTh ⏤᮶࡛ࡣ࡞ࡃࠊ233U ࡜ 232U ࡢፉ᰾✀ࡢቯኚ㸦ࢳ࢙ࣞࣥࢥࣇග㸧࡟ࡼࡗ࡚Ⓨ⏕ࡋࡓࡶࡢ࡛࠶ࡿ࡜
⪃࠼ࡽࢀࡿࠋ ࢞ࢫ୰࡛ 229mTh ࢆᤕ㞟ࡋࡓヨᩱ࠿ࡽࡣῶ⾶ࡍࡿᚤᙅ࡞ගᏊᡂศࡀᚓࡽࢀࡓࠋࡇࢀࡽࡢῶ⾶ᡂศࡶ MgF2୰࡟ᤕ㞟ࡋࡓヨᩱ࡜ྠᵝ࡟ 213Bi ࡸ 212Pb ࡢ༙ῶᮇ࡟
୍⮴ࡋࡓࠋⓎ⾲࡛ࡣ᭦࡟᮲௳ࢆኚ᭦ࡋ࡚ ᐃࢆ⾜ࡗࡓ⤖ᯝ࡟ࡘ࠸࡚ࡶྜࢃࡏ࡚ሗ࿌ࡍࡿࠋ

Fig. 1. MgF2 ୰࡟ 229mTh ࢆᤕ㞟ࡋࡓヨᩱࡢගᏊᐃ⤖ᯝ 㸦ᐇ⥺㸸ࣇ࢕ࢵࢸ࢕ࣥࢢ᭤⥺ ◚⥺㸸ࣂࢵࢡࢢࣛ࢘ࣥࢻ㸧ཧ⪃ᩥ⊩[1] B. R. Beck et al., LLNL-PROC-415170 (2009).
[2] L. von der Wense et al., Nature 533 (2016)47-51.
[3] X. Zhao et al., Phys. Rev. Lett. 109 (2012)

160801.
[4] Y. Shigekawa et al., Rev. Sci. Instrum. 87 (2016)053508.

Search for the ultraviolet photon emitted from the 229mTh samples collected as alpha-decay recoil products of 233U
Yuki Yasuda, Yoshitaka Kasamatsu, Yudai Shigekawa, Koichi Takamiya, Tsutomu Ohtsuki, Toshiaki Mitsugashira, Atsushi Shinohara
yasuday11@chem.sci.osaka-u.ac.jp

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㸦ி኱ཎᏊ⅔ࠊ⌮◊ ࠊᮾி㟁኱ 㸧‫ྜྷۑ‬Ọᑦ⏕ࠊ᪥㔝ṇ⿱ࠊ㔠ᒣ㞞ဢࠊ⣽␊ᣅஓ ࠊᒣᙧ㇏ ࠊ㒌Ụ ࠊ᳃⏣᫴ஓ ࠊṊ⏣᫴ ࠊྂᆏ㐨ᘯ ࠊᕝ➃♸ྖᅜෆእ࡟࠾࠸࡚୰ᛶᏊ㞟ග࣑࣮ࣛ㛤Ⓨࡣ┒ࢇ࡛࠶ࡿࡀࠊ㠀⌫㠃ࡣࡶ࡜ࡼࡾ෇⟄㠃࡛ࡶ኱ࡁࡃ␗࡞ࡿ ࡘࡢ᭤⋡ࢆᣢࡘࢺࣟ࢖ࢲ࣑࣮ࣝࣛࡢࡼ࠺࡞ᙧ≧ࡣ࡯࡜ࢇ࡝ᐇ⌧࡛ࡁ࡚࠸࡞࠸ࠋᡃࠎࡣ -67 ග࣭㔞Ꮚ⼥ྜ㐃ᦠ◊✲㛤Ⓨࣉࣟࢢ࣒ࣛࡢᨭ᥼ࢆཷࡅ࡚ࠊ ᖺ ᭶࡟୰ᛶᏊගᏛ⣲Ꮚ἞ල〇స⏝ 1& ไᚚຍᕤ⿦⨨0D]DN 〇ࡢ❧ᙧ࣐ࢩࢽࣥࢢࢭࣥࢱ &/+ ࢆᑟධࡋࡓࠋᮏⓎ⾲࡛ࡣ୰ᛶᏊ㞟ග࣑࣮ࣛࡢࡓࡵࡢ㔠ᒓᇶᯈ〇సࡢ⌧≧࡟ࡘ࠸࡚㏙࡭ࡿࠋ㸯㸬ࡣࡌࡵ࡟㸸୰ᛶᏊ㞟ග࣑࣮ࣛࡣࠊ⢒ຍᕤࠊࢽࢵ
ࢣ࣓ࣝࣜࣥࢵ࢟ࠊ㉸⢭ᐦຍᕤࠊ◊☻ࠊὙίࠊከᒙ⭷ࢥ࣮ࢸ࢕ࣥࢢࢆ⤒࡚୰ᛶᏊගᏛ⣲Ꮚ࡜ࡋ࡚᏶ᡂࡍࡿࠋ
㞟ග࣑࣮ࣛࡢ〇సࡣ⢭ᐦ࡞ຍᕤ࡜ᙧ≧ホ౯ࡀᚲ㡲࡛࠶ࡾࠊ◊☻ࡲ࡛ࡢྛᕤ⛬࡛ᙧ≧ホ౯ࡀ⾜ࢃࢀಟṇຍᕤ࡟ࡼࡾ⢭ᗘࢆ☜ಖࡍࡿࠋᮏ⿦⨨ࡢᑟධࡣ୍㐃ࡢᕤ⛬ࡢ୰࡛୺࡟᭱ึࡢ⢒ຍᕤ࡜ࡑࡢィ ホ౯ࢆᢸ࠺ࠋ
㸰㸬୰ᛶᏊ㞟ග࣑࣮ࣛࡢ〇స࡟ࡘ࠸࡚㸸ຍᕤࡍࡿ࣑
࣮ࣛ㠃ࡣ㛗㍈༙ᚄ Pࠊ▷㍈༙ᚄ PP ࡢᅇ㌿ᴃ෇యࡢ୍㒊࡛࠶ࡿ㸦)LJ㸧ࠋ୰ᚰ㒊ࡼࡾ㛗ࡉᕥྑ࡟ FP ඲㛗 FP ࠊ⣙ rࡢᖜࢆᣢࡘࠋᮦᩱ࡟ࡣᯈᮦ⏕⏘᫬࡟ṧ␃ࡍࡿ⇕ᛂຊࢆ㝖ཤࡋࡓ࡜ㅻ࠺ 6 ࢔࣑ࣝࢽ࣒࢘㸦࢔ࣝࣁ࢖ࢫ ,,,㸧ࢆ౑⏝ࡋࠊᯈᮦࡢᅛᐃ࡟ࡣ┿✵ࢳࣕࢵࢡࢆ౑⏝ࡍࡿ➼ࠊ⢭ᐦᙧ≧ຍᕤࡀฟ᮶ࡿࡼ࠺࡟㓄៖ࡋࡓࠋࡉࡽ࡟
ᮦᩱ⾲㠃ࡢຎ໬ࡸᙧ≧ࡢ⤒᫬ኚ໬ࢆ㑊ࡅࡿࡓࡵ࡟ᯈ
ᮦࡢ⾲㠃ࠊ⿬㠃ࢆษ๐ࡋ࡚ࡋࡤࡽࡃ㟼⨨ࡋࡓࡢࡕ௙
ୖࡆຍᕤࡍࡿ➼ࠊᵝࠎ࡞ຍᕤࢆ᪋ࡋࡓࠋ
࣑࣮ࣛࡣ㸱ࡘࡢ࣑࣮ࣛࢭࢢ࣓ࣥࢺ࠿ࡽᵓᡂࡉࢀࡿࠋ
ᚋᕤ⛬ࡢ㉸⢭ᐦษ๐࡟ࡣࣖࢺ࢖࡜࿧ࡤࢀࡿ㒊ရࡶᚲせ࡜࡞ࡿࡓࡵࠊ⢒ຍᕤࡢᕤ⛬࡛ేࡏ࡚〇సࡍࡿࠋࣖ
ࢺ࢖ࡣ࣑࣮ࣛࢭࢢ࣓ࣥࢺẖ࡟  ࢭࢵࢺᚲせ࡜࡞ࡿࡓࡵࠊ㏵୰࡛࣑࣮ࣛࢭࢢ࣓ࣥࢺࡢ୍㒊࠾ࡼࡧࣖࢺ࢖ࢆ

)LJගᏛ⣲Ꮚࡢ〇సᅗ㠃ࠋ࣑࣮ࣛ㠃ࡣᅇ㌿ᴃ෇య㸦㛗㍈㸹
PPࠊ▷㍈㸹PP㸧⬺╔ࡋ࡞ࡀࡽษ๐ຍᕤࢆ㐍ࡵࠊ⢒ຍᕤ࡜ࡋ࡚඘ศ࡞
PP ⛬ᗘࡢ⢭ᗘ࡛ࡢຍᕤ࡟ᡂຌࡋࡓࠋ㏻ᖖ⢒ຍᕤࡢ௙ୖࡆࡣ┤ᚄ PP ࡢ࣮࢚࣎ࣝࣥࢻ࣑ࣝ㸦5㸧࡛௙ୖࡆࡿࡀࠊᚋᕤ⛬࡜࡞ࡿ㉸⢭ᐦຍᕤ࡛౑⏝ࡍࡿ༢⤖ᬗࢲ࢖ࣖࣔࣥࢻࣂ࢖ࢺ㸦QHZ' ࣂ࢖ࢺ㸧࡟ࡼࡿษ๐
࡟ࡶᣮᡓࡋࡓࠋ௨ୗࡣࡑࡢ⤖ᯝࢆ㏙࡭ࡿࠋ㸱㸬⤖ᯝ㸸࣮࢚࣎ࣝࣥࢻ࣑ࣝ࡟ࡼࡿ௙ୖࡆษ๐ࡣ࣑
࣮ࣛࢭࢢ࣓ࣥࢺࠊ࠾ࡼࡧࣖࢺ࢖ࢆ⬺╔ࡋ࡚ࡶᚋᕤ⛬࡛ၥ㢟࡜࡞ࡿᙧ≧ㄗᕪࡣぢࡽࢀ࡞࠿ࡗࡓࠋ⥆ࡅ࡚
QHZ' ࣂ࢖ࢺ࡛ษ๐ࡋࡓ࡜ࡇࢁࠊඛ࡟ຍᕤࡋࡓ࣑࣮ࣛ
ࢭࢢ࣓ࣥࢺ࡜ᚋ࠿ࡽྲྀ௜ࡅ࡚ຍᕤࡋࡓࣖࢺ࢖࡜࡛┠ど࡛☜ㄆ࡛ࡁࡿ࡯࡝ࡢẁᕪࡀ⏕ࡌ࡚࠸ࡓࠋ୺㍈࡬ࡢ
QHZ' ࣂ࢖ࢺࡢᅛᐃࡣࢩ࢙࣮ࣃࣜࣥࢢຍᕤ㸦࣮࢜ࣜࣥࢢྲྀ௜ࡅ⁁ࡢຍᕤ࡞࡝㸧⏝ࡢ࣍ࣝࢲ࣮ࢆ౑⏝ࡋࡓࠋ୺㍈ࡢ㍈ᚰ࠿ࡽษ๐ᕤලࡢ㍈ᚰࢆࢲ࢖ࣖࣝㄪᩚ࡟ࡼ
ࡗ࡚㐃⥆ⓗ࡟࢜ࣇࢭࢵࢺᅛᐃ࡛ࡁࡿᵓ㐀࡟࡞ࡗ࡚࠸
ࡿࡀࠊ㛗᫬㛫ࡢ೫ࡗࡓຍᕤ࡟ࡼࡾྲྀ௜⢭ᗘ࡟ၥ㢟ࡀ
Ⓨ⏕ࡋࡓࡶࡢ࡜⪃࠼ࡓࠋࡇࡢ⤖ᯝࢆ࠺ࡅ࡚ᕤලࡢᅛ

)LJ㛤Ⓨ୰ࡢᕤල࣍ࣝࢲ࣮㸦ᕥ㸧ࠊ࠾ࡼࡧษࡾ⢊㝖ཤ⿦⨨ ྑ ᐃ᪉ἲࡢኚ᭦ࢆ᳨ウࡋ࡚࠸ࡿ㸦)LJ㸧ࠋࡲࡓࠊษ๐ᾮ࡟ࡣษ๐ᕤල࡜⿕ษ๐≀㛫ࡢ෭༷࡜₶⁥๣࡜ࡋ࡚ᖖ᫬࠿ࡅὶࡋࡢࢡ࣮ࣛࣥࢺ㸦࢚࣐ࣝࢪࣙ
ࣥᆺ㸧ࢆ౑⏝ࡋ࡚࠸ࡿࡀࠊ㛗᫬㛫ࡢຍᕤ࡟ࡼࡾ₶⁥๣࡜ࡋ࡚ࡢᛶ⬟ࡀຎ໬ࡋ࡚ࡃࡿࠋཎᅉࡣ࣐ࢩࢽࣥࢢ
ࢭࣥࢱෆ㒊ࢆᚠ⎔ࡍࡿ࠺ࡕ࡟ࢡ࣮ࣛࣥࢺࢱࣥࢡቨ࡬
ࡢ௜╔࡟ࡼࡿῶᑡࡸࠊษࡾ⢊࡬ࡢ྾╔࡟ࡼࡿῶᑡ࡞
࡝ࡀ⪃࠼ࡽࢀࡿࠋࡇࡢ࠺ࡕࠊ⃰ᗘࡢῶᑡ࡟ࡘ࠸࡚ࡣ
ᐃᮇⓗ࡞ཎᾮࡢ⿵⤥࡟ࡼࡗ࡚ᑐ⟇࡛ࡁࡿࡀࠊຎ໬ࡋ
ࡓࢡ࣮ࣛࣥࢺᾮࢆ㢖⦾࡟஺᥮ࡍࡿࡢࡣᡭ㛫࡜࡞ࡿࡓࡵຎ໬ࡢཎᅉ࡜࡞ࡿษࡾ⢊ࡢ㝖ཤࢆຠ⋡ⓗ࡟⾜࠼ࡿษࡾ⢊㝖ཤ⿦⨨ࢆ㛤Ⓨࡋ࡚࠸ࡿ㸦)LJ㸧ࠋ㸱㸬ࡲ࡜ࡵ㸸ᅇ㌿ᴃ෇యࡢ᭤㠃ࢆ᭷ࡍࡿ㔠ᒓᇶᯈࡢ⢒ຍᕤࢆᐇ᪋ࡋࡓࠋ⢒ຍᕤ࡜࠸ࡗ࡚ࡶࡑࡢ⢭ᗘࡣ㧗ࡃࠊࡲࡓ㞟ග࣑࣮ࣛ㛤Ⓨᕤ⛬࡟࠾࠸࡚ࡶ඘ศ࡞⢭ᗘࢆ㐩ᡂ࡛ࡁࡓࠋࡉࡽ࡟㉸⢭ᐦຍᕤ࡟‽ࡎࡿ㧗⢭ᗘຍᕤࢆ┠ᣦࡋࡓࡀࠊᕤල࣍ࣝࢲ࣮ࡢ⢭ᗘྥୖࠊ࠾ࡼࡧ
ษ๐ᾮࡢ⟶⌮࡟ࡘ࠸࡚ᨵၿࡍ࡭ࡁⅬࡀぢࡘ࠿ࡗࡓࠋ
ᮏⓎ⾲࡛ࡣຍᕤࡢ⌧≧࡜ᨵၿ⟇ࠊ௒ᚋࡢᒎ㛤࡟ࡘ࠸
࡚㏙࡭ࡿࠋ

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3ĿI:PBKS°wŅĀĀĭ+Ŀ*ńĀ+ FSM4'|2)ĿýŅĀ+ SLL-2 *¿üħ*Ķ¡ħd)b-%ă{5'Ĉ365ŀ

xĈ·ä
[1] M. Jimbo, et al., Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 125 (2000) 227–236.
[2] K. Koike, et al., Biol. Bull. 207 (2004) 80–86.
[3] M. Jimbo, et al., Biochem. Biophys. Res. Commun.
330 (2005) 157-162.
[4] M. Jimbo, et al., J. Exp. Mar. Biol. Ecol. 439 (2013)
129–135.
[5] A. Kita, et al., Glycobiology 25 (2015) 1016-1023.

Crystal structure of the complex between lectin from octocoral and tetrasaccharides
Akiko Kita, Mitsuru Jimbo, Ryuichi Sakai, Yukio Morimoto, Ryota Takeuchi, Hiroshi Tanaka, Takashi TakahashiKunio Mikikita@rri.kyoto-u.ac.jp

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㸦ி኱㝔ᕤࠊி኱ཎᏊ⅔㸯㸧‫ۑ‬すᕝᑗ࿃ࠊᑠᯘ኱ᚿࠊబࠎᮌ㝯அࠊୖཎ❶ᐶ㸯
1. ⥴ゝ㸸㧗ࣞ࣋ࣝᨺᑕᛶᗫᲠ≀ࡢᆅᒙฎศ࡛ࡣࠊᆅ
⇕ࡸ࢞ࣛࢫᅛ໬యࡢⓎ⇕ࡢᙳ㡪࡟ࡼࡾࠊฎศᚋ࠾ࡼ
ࡑ 1000 ᖺ㏆ࡃ࡟ࢃࡓࡗ࡚⦆⾪ᮦෆእࡢ ᗘࡀ 60°C
௨ୖ࡟࡞ࡿ࡜᝿ᐃࡉࢀࡿ[1]ࠋ4 ౯࢔ࢡࢳࣀ࢖ࢻỈ㓟໬≀ࡢ⁐ゎᗘࡣฎศ⎔ቃࡢ ᗘ᮲௳࡟ᕥྑࡉࢀࠊ౛
࠼ࡤࠊ⁐ᾮ ᗘࢆ 90°C ࡟ୖ᪼ࡉࡏࡿ࡜⁐ゎᗘࡀపୗࡍࡿ࡜࡜ࡶ࡟ࠊ⁐ゎᗘไ㝈ᅛ┦࡛࠶ࡿ࢔ࣔࣝࣇ࢓ࢫ
≧Ỉ㓟໬≀ࡢ≧ែࡀኚ໬ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ
[2]ࠋࡋ࠿ࡋࠊࡇࡢࡼ࠺࡞ ᗘ࡟ࡼࡿᅛ┦≧ែ࡜⁐ゎᗘࡢኚ໬ࢆᐃ㔞ⓗ࡟㛵㐃௜ࡅࡿࡇ࡜ࡣࠊࡇࢀࡲ࡛Ṥ࡝࡞ࡉࢀ࡚࠸࡞࠸ࡢࡀ⌧≧࡛࠶ࡿࠋᮏ◊✲࡛ࡣࠊ4౯࢔ࢡࢳࣀ࢖ࢻ࡛࠶ࡿࢺ࣒ࣜ࢘(Th)ࡢỈ㓟໬≀࡟╔┠ࡋࠊ25°Cࠊ40°C ཬࡧ 60°C ⇍ᡂ᫬ࡢぢ࠿ࡅࡢ⁐ゎᗘ࡞ࡽࡧ࡟ᅛ┦⢏ᚄࢆ pHc 2~10 ࡟࠾࠸࡚ ᐃࡋࠊThỈ㓟໬≀ࡢ⁐ゎᗘ✚ࡢ ᗘ౫Ꮡᛶࢆゎ㔘ࡍࡿࡇ࡜ࢆ
ヨࡳࡓࠋࢺࣝ࡟᫂☜࡞ࣆ࣮ࢡࡀぢࡽࢀࡎࠊึᮇࡢ࢔ࣔࣝࣇ࢓
ࢫ≧Ỉ㓟໬≀࠿ࡽᅛ┦ࡀኚ໬ࡋ࡚࠸࡞࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ୍᪉࡛ 40°C ཬࡧ 60°C ࡛⇍ᡂࡋࡓᅛ┦ࡢࢫ࣌ࢡࢺࣝ࡟ࡣ ThO2(cr)࡟┦ᙜࡍࡿࣆ࣮ࢡࡀ⌧ࢀࡓࠋࡇࡢࡇ࡜࠿ࡽࠊ ᗘୖ᪼࡟కࡗ࡚ Th(OH)4(am)ࡢ⤖ᬗ໬ࡀ㐍⾜ࡋ⁐ゎᗘࡀపୗࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ
᪤ ◊✲࡛ࡣࠊᅛ┦୰ࡢ⤖ᬗ⢏Ꮚࡢ⏺㠃⮬⏤࢚ࢿࣝࢠ࣮࡜⾲㠃✚࡜ࡢ㛵ಀࢆᇶ࡟ Ksp ࡢపୗ࡜ᅛ┦ࡢ⤖ᬗ໬࡟㛵ࡍࡿ༙⤒㦂ⓗ࡞ㄝ᫂ࡀヨࡳࡽࢀ࡚ࡁࡓ[3]ࠋ
ᮏ◊✲ࡢ Ta =40, 60°C ࡢྛᅛ┦ࡢᐇ㦂⤖ᯝࢆ᪤ሗ್
࡜ẚ㍑ࡋࡓ࡜ࡇࢁࠊ௒ᅇᚓࡽࢀࡓ Ksp ࡣ⤖ᬗᏊࡢ⢏ᚄ࠿ࡽண᝿ࡉࢀࡿࡼࡾࡶ⣙ 1 ᱆㧗ࡃࠊ⤖ᬗᏊ⢏ᚄࡔࡅ
࡛ࡣ Ksp ࡢ್ࡢㄝ᫂ࡣᅔ㞴࡜⪃࠼ࡽࢀࡓࠋ௒ᚋࠊKsp
ࡢ Tm ౫Ꮡᛶ࠿ࡽྛᅛ┦ࡢ⁐ゎ཯ᛂࡢ ΔH ࡜ ΔS ࢆ⟬ฟࡍࡿࡇ࡜࡛ྛ⇍ᡂᅛ┦ࡢ≧ែࢆࡉࡽ࡟⪃ᐹࡍࡿࠋ

3. ⤖ᯝ࣭⪃ᐹ㸸pHc ᐃཬࡧ㝈እࢁ㐣᫬ࡢ ᗘࢆ Tm
࡜ࡍࡿࠋTa =25㹼60°C ࡢྛᅛ┦࡟ࡘ࠸࡚ࠊTm =25°C
࡛ࡢ⁐ゎᗘࢆᅗ 1 ࡟♧ࡍࠋ⇍ᡂ ᗘࡀୖ᪼ࡍࡿ࡜࡜
ࡶ࡟⁐ゎᗘࡀపୗࡍࡿഴྥࢆ♧ࡋࡓࠋᚓࡽࢀࡓ⁐ゎᗘ࠿ࡽ⁐ゎᗘ✚ࢆồࡵࡓ࡜ࡇࢁࠊTa =25, 40, 60°C ࡢྛ ᅛ ┦ ࡟ ࡘ ࠸ ࡚ ࠊ ࡑ ࢀ ࡒ ࢀ logKspo=-49.06±0.16,-50.00±0.36, -50.31±0.30 ࡜࡞ࡗࡓࠋXRD ࡟ࡼࡿᅛ┦ศᯒࡢ⤖ᯝࠊ25°C ࡛⇍ᡂࡋࡓᅛ┦࡟ࡘ࠸࡚ࡣࢫ࣌ࢡ

ᵲᵿᵛᵐᵓḥᵊᴾᵲᶋᵛᵐᵓḥ

ᵲᵿᵛᵒᵎḥᵊᴾᵲᶋᵛᵐᵓḥ

ORJ>7K@

2. ᐇ㦂㸸◪㓟ࢺ࣒ࣜ࢘ヨ⸆(Th(NO3)4࣭5H2O)ࢆ㉸⣧Ỉ࡟⁐ゎࡋࠊNaOH Ỉ⁐ᾮࢆຍ࠼ࡿࡇ࡜࡛࢔ࣔࣝࣇ࢓ ࢫ Ỉ 㓟 ໬ ≀ ỿ Ẋ (Th(OH)4(am)) ࢆ ㄪ 〇 ࡋ ࡓ ࠋ
Th(OH)4(am)ỿẊࢆ pHc ࡜࢖࢜ࣥᙉᗘ(I ) ࢆㄪᩚࡋࡓ
⁐ᾮ࡟ึᮇᅛ┦࡜ࡋ࡚ῧຍࡋࠊヨᩱ⁐ᾮ࡜ࡋࡓࠋpHc
ࡣ HClO4 ࡲࡓࡣ NaOH ࡟ࡼࡾ pHc 2㹼10ࠊ࢖࢜ࣥᙉᗘࡣ NaClO4 ࡟ࡼࡾ I =0.5 ࡟ㄪᩚࡋࡓࠋヨᩱࡣᜏ ᣺࡜࠺ჾෆ࡛ࡺࡿࡸ࠿࡟᣺࡜࠺ࡋ࡚⇍ᡂࡉࡏࡓࠋ⇍ᡂ᫬ࡢ ᗘ(Ta )ࡣ 25°Cࠊ40°C ࠾ࡼࡧ 60°C ࡜ࡋࡓࠋᡤ
ᐃᮇ㛫ࡢ⇍ᡂᚋࠊྠ ᗘ࡛ヨᩱ⁐ᾮࡢ pHc ᐃཬࡧୖ⃈ࡳᾮࡢ㝈እࢁ㐣(ศ⏬ศᏊ㔞 3kDa ࣇ࢕ࣝࢱ)ࢆ⾜࠸ࠊࢁᾮ࡟ྵࡲࢀࡿ Th ⃰ᗘࢆ ICP-MS ࡛ᐃ㔞ࡋࡓࠋ
ࡲࡓࠊTh ⃰ᗘࡀᐃᖖ≧ែ࡟㐩ࡋࡓᚋࠊᩘ᪥㛫ࠊヨᩱࢆ⇍ᡂ᫬ࡼࡾࡶప࠸ ᗘ⎔ቃୗ࡟⨨ࡁࠊࡑࡢ ᗘ⎔ቃୗ࡛ࡢ pHc ࡜⁐ゎᗘࢆ ᐃࡍࡿࡇ࡜࡛ྛ⇍ᡂᅛ┦ࡢ⁐ゎᗘ✚(Ksp)ࡢ ᗘ౫Ꮡᛶࢆㄪ࡭ࡓࠋࡲࡓࠊ࠸ࡃ
ࡘ࠿ࡢヨᩱࡣࠊᅛ┦ࢆ㐲ᚰศ㞳ࡋࠊᖖ ࡛஝⇱ࡉࡏࠊX ⥺ᅇᢡ(XRD)࡟ࡼࡾศᯒࡋࡓࠋSherrer ࡢᘧࢆ⏝࠸࡚ࠊほ ࡉࢀࡓࣆ࣮ࢡࡢ್༙ᖜ࠿ࡽ⤖ᬗᏊࡢ⢏ᚄࢆ
ồࡵࡓࠋ



ᵲᵿᵛᵔᵎḥᵊᴾᵲᶋᵛᵐᵓḥ















S+F

Figure 1. Solubility of thorium hydroxide aged at 25°C,
40°C and 60°C. Aliquots of the supernatants were filtrated through 3kDa membranes. pH measurement and filtration were done at 25°C.
ཧ⪃ᩥ⊩[1] ᰾⇞ᩱࢧ࢖ࢡࣝ㛤Ⓨᶵᵓࠊ“ᆅᒙฎศ◊✲㛤Ⓨ➨
2 ḟྲྀࡾࡲ࡜ࡵ―ศ෉ 1”ࠊ1999.
[2] D. Rai et al., “Thermodynamic model for the solubility of thorium dioxide in the Na+-Cl–-OH–-H2O system at
23°C and 90°C” Radiochim. Acta 88 (2000) 297-306.
[3] M. Rand et al., “Chemical Thermodynamics of Thorium” Elsevier. Amsterdam, 2009.

Interpretation of temperature effect on the solubility and solid phase of thorium hydroxide
Shogo Nishikawa, Taishi Kobayashi, Takayuki Sasaki, Akihiro Uehara
nishikawa.shogo.88a@st.kyoto-u.ac.jp

㻙 㻠㻡㻌㻙

㻔㻼㻟㻞㻕 ࢫࢺࣟࣥࢳ࣒࢘ཬࡧ࢝ࣝࢩ࣒࢘ࡢ໬Ꮫ஺᥮ἲ࡟࠾ࡅࡿྠ఩యศู◊✲ III㸦኱⏘኱ࠊᮾᕤ኱ཎᏊ⅔ ࠊ㜰኱ᕤࠊி኱⅔ 㸧‫◶ۑ‬㝯ኴࠊ⩏ᮏᏕ᫂ࠊబஂ㛫ὒ୍ࠊ⸨஭ಇ⾜2ࠊ⚟㇂ဴ3ࠊⰪཎ㞝ྖ3㸯㸬ࡣࡣࡌࡵ࡟㸸ࢫࢺࣟࣥࢳ࣒࢘ࡢ᰾✀⛣⾜࡟క࠺ྠ఩యศู◊✲࡜ࡋ࡚ࠊྠ఩యຠᯝࡀぢࡸࡍࡃྲྀᢅ࠸
ࡶᐜ᫆࡞ྠ᪘ඖ⣲ࡢ࢝ࣝࢩ࣒࢘ࢆ⏝࠸࡚ࠊ㉁㔞ศᯒィ࡟ࡼࡾࠊ኱⎔≧࣏࢚࣮ࣜࢸࣝ㸦ྛ✀ࢡ࢚࣮ࣛ࢘ࣥ
ࢸࣝ㸧➼࡟ࡼࡿᾮᾮᢳฟ࣭໬Ꮫ஺᥮ἲ࡟ᑐࡍࡿྠ఩
యศูຠᯝࠊ≉࡟ࣇ࢕࣮ࣝࢻࢩࣇࢺࠊ࣐ࢫࢩࣇࢺࠊ
᰾ࢫࣆࣥຠᯝ➼ࠊ㉁㔞࡟౫Ꮡࡋ࡞࠸ྠ఩యຠᯝࡶྵ
ࡵࡓ౫Ꮡᛶࡢ᳨ドࢆ⾜࠺ࠋᐇ 㦂㸸 40Ca2+(Ỉ┦)‫ݸ‬48Ca2+L(᭷ᶵ┦)я 48Ca2+(Ỉ㸰㸬ᐇ┦)‫ݸ‬40Ca2+L(᭷ᶵ┦): (L ࡣࢡ࢚࣮ࣛ࢘ࣥࢸࣝ)ᾮ-ᾮᢳฟἲ࡛ࠊୖグ໬Ꮫᖹ⾮࡟ࡼࡾ㑅ᢥⓗ࡟㍍ඖ⣲(40Ca)ࡀࢡ࢚࣮ࣛ࢘ࣥࢸࣝഃ࡟⃰⦰ࡉࢀࠊTIMS ࢆ⏝࠸ࡓྠ఩యẚ ᐃ࠿ࡽ㉁㔞ຠᯝࢆ☜ㄆࡋࡓࠋ⤖ᯝ㸸⾲㸯࡟ࡇࢀࡲ࡛ࡢ Sr ཬࡧ Ca ࡢ༢఩㉁㔞
㸱㸬⤖ᙜࡾࡢศ㞳ಀᩘࡢ୺࡞ᐇ㦂⤖ᯝ୍ぴ (᫖ᖺ୍࣭᫖ᖺ
ᗘሗ࿌࡜ేࡏࠊ᭱᪂⤖ᯝࢆ⥙⨶) ࢆ♧ࡍࠋ⥲ࡌ࡚ࠊ
Sr࣭Ca ඹ࡟ࠊࢡ࢚࣮ࣛ࢘ࣥࢸࣝࡣ࢖࢜ࣥ஺᥮ἲ࡜ẚ㍑ࡋ࡚ᩘ༑ಸࡢศ㞳ಀᩘࢆ୚࠼ࠊྠ఩యຠᯝ࡟␃ࡲ
ࡽࡎศ㞳࡟ᛂ⏝ྍ⬟࡞⬟ຊࢆ᭷ࡋ࡚࠸ࡿ࡜࠸࠼ࡿࠋ
Ȝ/‫ڹ‬M[10-5]

Method and system

51~17
(Sr)

Liquid-liquid
extraction(LLE) with dicyclohexano-18-crown-6 (DC18C6).
2.3M-0.5M Sr in aqueous
phase.
LLE with DC18C6.
0.07M CHCl3
SLC with ion exchange
resin (Dowex1,50).
SLC with ion exchange
resin (Dowex50W).
SLC with ion exchange
resin (Dowex) with NH4
Ș-hydroxyisobutyrate
SLC with ion exchange
resin (ANKB-50) withiminodiacetate
SLC with ion exchange
resin (PK-1) with counter-current
SLC with ion exchange
resin (Asahi LS-6)
SLC with ion exchange
resin (AG50WX4)

100
(Ca)
3.7
(Ca)
5.3
(Ca)
11
(Ca)
51
(Ca)
13~87
(Ca)
2~5.2
(Ca)
12
(Ca)

Temp
.
(Υ)
20±0.
5

Ref.

[1]

88
(Ca)

SLC with crown-ether
88[10]resin (18C6, dimethylsulfoxide)35
36
SLC with crown-ether
[11]
(Ca)
resin (benzo-18C6).
0+&O PPĳP
30
SLC with crown-ether
35(Ca)
resin (benzo-18C6).
0+&O PPĳP
75
SLC with crown-ether
25
[12]
(Ca)
resin (benzo-18C6).
Methanol38
SLC with crown-ether
40
[13]
(Ca)
resin (benzo-18C6).
8M HCl25%+Ethanol75%
13~24
Ion Exchange Electromi- 20,25 [14](Ca)
gration,40
48/43=3# Multi-channel
coun- <100[15]
ter-current electrophoresis
25
[16]
46
SLC with crown-ether(Ca)
resin (benzo-18C6).
CH3COOH95%+H2O5%
PPĳP
150 *LLE with DC18C6
20
This
(Ca)
0.07M CHCl3
work
175 *
LLE with DC18C6
2
This
(Ca)
0.07M CHCl3
work
7DEOH  8QLW PDVV HQULFKPHQW IDFWRUV RI 6U DQG
&D LVRWRSH VHSDUDWLRQ (QULFKPHQW IDFWRU IRU


25

[2]

̿

[3]

̿

[4]

̿

[5]

̿

[6]

24-82

[7]

25

[8]

25

[9]

&D&D 3UHOLPLQDU\ཧ⪃ᩥ⊩[1]K.Nishizawa et al.,J.Nucl.Sci.Technol., 32(1995)1230.
[2]B.E. Jepson et al., J. Inorg. Nucl. Chem.38(1976)1175.
[3]D.A. Lee, J. Inorg. Nucl. Chem. 38(1976) 161.
[4]W.A. Russell et al., Anal. Chem. 50(1978)1151.
[5]J. Aaltonen, J. Suomen Kemi B44(1971)1.
[6]V.V.Gutsykov et al., Russ.J.Phys.Chem.55(1981)1667.
[7]N. Kobayashi, J. Chromatogr. 252(1982)121.
[8] T. Oi et al., Sep. Sci. Technol., 28 (1993) 1971.
[9]B.E.Jepson et al., Sep. Sci. Technol., 22 (1984) 1029.
[10]B.E.Jepson et al., Sep. Sci. Technol., 28(1993) 507.
[11]S.Umehara et al.,Prog.Theor.Exp.Phys.2015,053C03.
[12]S.Nemoto et al.,Isotopes Envir.Heal.Stu.49(2013)257[13]S. Okumura et al., J. Chromatogr. A1415(2015)67.
[14]Y. Fujii et al.,Z. Natureforsch, 40a (1985) 843.
[15]T.Kishimoto et al.,Prog.Theor.Exp.Phys.2015,33D03[16]S.Umehara et al.,Austin Chromatogr. 3 (2016)1040.

Study of Isotope Separation of Strontium and Calcium via Chemical Exchange Reaction III
Ryuta Hazama, Takaaki Yoshimoto, Yoichi Sakuma, Toshiyuki Fujii, Satoshi Fukutani, Yuji Shibahara
hazama@due.osaka-sandai.ac.jp

㻙 㻠㻢㻌㻙

㻔㻼㻟㻟㻕 .85% Ꮝࢆ฼⏝ࡋࡓప㏿㝧㟁Ꮚࣅ࣮࣒ࣛ࢖ࣥ㍤ᗘቑᙉ㒊ࡢ㛤Ⓨ㸦ி኱ཎᏊ⅔ࠊ⏘⥲◊ ࠊ㮵ඣᓥ኱ᕤ 㸧‫ⴱۑ‬㇂ ెᗈࠊ኱ᓥ Ọᗣ ࠊᮌ㔝ᮧ ῟ࠊ⡦ෆ ᩔࠊబ⸨ ⣫୍ ࠊᚎ ⹹㸯㸬ࡣࡌࡵ࡟㸸㝧㟁Ꮚ㸦H㸧ࡣ㟁Ꮚ㸦H㸧ࡢ཯⢏Ꮚ࡛࠶ࡾࠊ㟁Ꮚ࡜ᑐᾘ⁛ࢆ㉳ࡇࡋࠊȖ ⥺࡟ኚ᥮ࡉࢀࡿᛶ㉁ࢆᣢࡘࠋࡑࡢ≉␗࡞ᛶ㉁ࢆ฼⏝ࡋࡓᵝࠎ࡞ᮦᩱศᯒ
᪉ἲࡀ⪃࠼ࡽࢀ࡚ࡁࡓ>@ࠋ⥲ࡌ࡚㝧㟁Ꮚᾘ⁛ศගἲ࡜࿧ࡤࢀࡿࡀࠊ≉࡟ᴟᚤ࡞ࠕ✵ᏍᆺḞ㝗ࠖࡢ᳨ฟ࠾
ࡼࡧࢧ࢖ࢬࡢホ౯ࢆᚓព࡜ࡍࡿᡭἲ࡛࠶ࡿࠋ
ி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤ࡛ࡣࠊ ᖺࡼࡾࠊ.85%
Ꮝࢆ฼⏝ࡋࡓ㧗ᙉᗘప㏿㝧㟁Ꮚࣅ࣮࣒ࣛ࢖ࣥࡢ㛤Ⓨࢆ㐍ࡵ࡚ࡁࡓ>@ࠋヨᩱ࡟ᑐࡋ࡚௵ពࡢ࢚ࢿࣝࢠ࣮
㸦±NH9㸧࡛㝧㟁Ꮚࡢᡴࡕ㎸ࡳࡀྍ⬟࡛࠶ࡿࡓࡵࠊ
⾲㠃㸦㏆ഐ㸧ࡸⷧ⭷ ᐃࡀྍ⬟࡜࡞ࡿࠋࡲࡓࠊ㧗ᙉᗘࢆά࠿ࡋࡓ㧗ィᩘ⋡ࡢヨᩱ ᐃࡀྍ⬟࡜࡞ࡿࠋࡇࢀࡲ࡛࡟㸦 ᖺ  ᭶㸧ࠊ 0: 㐠㌿᫬࡟ࠊîV ࡢ㝧㟁Ꮚ⏕ᡂࢆ☜ㄆࡋ࡚࠸ࡿ>@ࠋᮏⓎ⾲࡛
ࡣ㍤ᗘቑᙉ㒊㛤Ⓨࡢ≧ἣ࡟ࡘ࠸࡚㏙࡭ࡿࠋ
㸰㸬㍤ᗘቑᙉ㒊ࡢ㛤Ⓨ㸸ཎᏊ⅔࣮࣋ࢫࡢ㝧㟁Ꮚࣅ࣮࣒ࣛ࢖࡛ࣥࡣ㧗ᙉᗘ࡞㝧㟁Ꮚࡀᚓࡽࢀࡿࡀࠊึᮇࣅ
࣮࣒ᚄࡀẚ㍑ⓗ኱ࡁࡃ࡞ࡿ㸦.85 ࡛ࡣaPP㸧ࠋ㝧㟁Ꮚᾘ⁛ศග୍࡛⯡ⓗ࡟⏝࠸ࡽࢀࡿヨᩱࢧ࢖ࢬࡣ୍
㎶  PP ゅ⛬ᗘ࡛࠶ࡿࡓࡵࠊィ ࡢࡓࡵ࡟ࡣࣅ࣮࣒
ᚄࢆᑠࡉࡃࡍࡿࡇ࡜ࡀᮃࡲࡋ࠸ࠋ୍᪉ࠊ㝧㟁Ꮚᙉᗘࡣィ ᫬㛫࡟ᙉࡃᙳ㡪ࢆ୚࠼ࡿࡓࡵࠊࣅ࣮࣒㞟᮰ࡢ㝿࡟ࣅ࣮࣒ᙉᗘᦆኻࢆᢚ࠼ࡓ࠸ࠋࡑࡇ࡛ࠊ㍤ᗘቑᙉ㒊ࡢᑟධࢆ⾜ࡗࡓࠋ㍤ᗘቑᙉ㒊ࡣࠊຍ㏿ࢠࣕࢵࣉࠊ☢⏺ࣞࣥࢬࠊ෌ῶ
㏿ᮦࠊ㍺㏦⏝ࢯࣞࣀ࢖ࢻࢥ࢖ࣝ㸦6&㸧࠿ࡽᵓᡂࡉࢀ
ࡿ㸦ᅗ 㸧ࠋୖὶࡼࡾ☢ሙ㍺㏦ࡉࢀ࡚ࡁࡓ㝧㟁Ꮚࢆa
NH9 ࡲ࡛ຍ㏿ࡋࠊ☢ሙࡢᙅ࠸㡿ᇦ࡬࡜ᘬࡁฟࡋࡓᚋࠊ
☢⏺ࣞࣥࢬ࡟ࡼࡾ෌ῶ㏿ᮦ࡟㞟᮰ࡉࡏࡿࠋ෌ῶ㏿ᮦ࡟ࡣ༢⤖ᬗࡢ 1L ⟩㸦 QP㸧ࢆ฼⏝ࡍࡿࠋ1L ࡣ㝧㟁Ꮚ࡟ᑐࡋ࡚㈇ࡢ௙஦㛵ᩘࢆᣢࡘࡓࡵࠊධᑕࡋࡓ㝧㟁Ꮚࡢ୍㒊ࡣ཯ᑐഃࡢ㠃࠿ࡽ෌ᨺฟࡉࢀࡿࠋ෌ᨺฟ
ຠ⋡ࡣ ±࡛࠶ࡿࡀࠊࣅ࣮࣒ࡢ᩿㠃✚࠾ࡼࡧⓎᩓ
ゅࡀᑠࡉࡃ࡞ࡿࡓࡵࠊ༢఩㠃✚ᙜࡓࡾ࡛⪃࠼ࢀࡤ㝧㟁Ꮚᩘࢆቑࡸࡍࡇ࡜ࡀฟ᮶ࡿࠋ⤖ᯝⓗ࡟኱ᖜ࡞㍤ᗘ
ቑᙉࡀᮇᚅ࡛ࡁࡿࠋ
㍤ᗘቑᙉ㒊ࡢタィࡣ⏘⥲◊ࡢྠࢩࢫࢸ࣒ࢆཧ⪃࡟ࡋ࡚⾜ࡗࡓࠋ⏘⥲◊࡜ .85 ࡢࢩࢫࢸ࣒ࡢ㐪࠸ࡣࠊ㍤
ᗘቑᙉᚋࡢ㝧㟁Ꮚ㍺㏦᪉ᘧ࡟࠶ࡿࠋ.85 ࡛ࡣ㍤ᗘቑ
ᙉᚋ࡟ࣃࣝࢫ໬ࢆ⾜࠺ࡓࡵࠊ㝧㟁Ꮚࢆప㏿ࡢࡲࡲ㍺㏦ྍ⬟࡞☢ሙ㍺㏦᪉ᘧࢆྲྀࡾධࢀࡓࠋ௨ୖࢆ㋃ࡲ࠼
࡚ࠊ≉࡟☢⏺ࣞࣥࢬࡢタィࢆ⾜࠸ࠊ㍤ᗘቑᙉ㒊ࢆࣅ࣮࣒ࣛ࢖ࣥ࡟ᑟධࡋࡓࠋ
㸳㸬㍤ᗘቑᙉ㒊ࡢගᏛ≉ᛶ㝧㟁Ꮚࣅ࣮࣒࡟ࡼࡿᐇ㦂ࢆ⾜࠺๓࡟ࠊ㍤ᗘቑᙉ㒊ࡢගᏛ≉ᛶࢆ㟁Ꮚࣅ࣮࣒࡟ࡼࡾࢸࢫࢺࡋࡓ㸦ᅗ 㸧ࠋ☢⏺ࣞࣥࢬࡢୖὶ⣙  P ࡛⏕ᡂࡉࢀࡓ㟁Ꮚࢆ☢⏺
ࣞࣥࢬᡭ๓ࡲ࡛☢ሙ࡟ࡼࡾ㍺㏦ࡋࠊNH9 ࡲ࡛ຍ㏿ࡍࡿࠋࡑࡢᚋࠊ☢ሙࡢᙅ࠸㡿ᇦ࡟ᘬࡁฟࡋࠊ☢⏺ࣞࣥࢬ࡟ࡼࡾ෌ῶ㏿ᮦ఩⨨࡟㞟᮰ࡉࡏࡿࠋᮏࢸࢫࢺ࡛ࡣࠊ
෌ῶ㏿ᮦ఩⨨࡟ฟࡋධࢀྍ⬟࡞ 0LFUR &KDQQHO 3ODWH
㸦0&3㸧࡟ྲྀࡾ௜ࡅࡽࢀࡓ⺯ගᯈ࡟ྍど໬ࡉࢀࡓࣅ
࣮࣒ࢆ࣓࡛࢝ࣛ᧜ᙳࡋࡓࠋ᧜ᙳࡋࡓ⏬ീࡢ㍤ᗘ್࠿
ࡽࣄࢫࢺࢢ࣒ࣛࢆసᡂࡋࠊ್༙ᖜ㸦):+0㸧࠿ࡽࣅ࣮࣒ᚄࢆぢ✚ࡶࡗࡓࠋྛࢥ࢖ࣝࡢࣃ࣓࣮ࣛࢱࢆㄪᩚࡋࡓ⤖ᯝࠊึᮇࣅ࣮࣒ᚄ PP ࡢ㟁Ꮚࣅ࣮࣒ࢆ PP ࡟㞟᮰࡛ࡁࡿࡇ
࡜ࡀศ࠿ࡗࡓࠋⲴ㟁⢏Ꮚ㌶㐨ィ⟬ࢥ࣮ࢻ࡛࠶ࡿ *37
࡟ࡼࡿ㌶㐨ィ⟬࠿ࡽࡶྠᵝ࡞⤖ᯝ㸦PP㸧ࡀᚓࡽࢀࡓࠋㅮ₇఍࡛ࡣࠊィ⟬⤖ᯝ࡜ᐇ㦂⤖ᯝࢆẚ㍑ࡋ࡞
ࡀࡽࠊ㍤ᗘቑᙉ㒊ࡢගᏛ≉ᛶ࡟ࡘ࠸࡚ሗ࿌ࡍࡿࠋ

)LJ$VFKHPDWLFYLHZ RIWKHEULJKWQHVVHQKDQFHPHQW
V\VWHP)LJ7KHLQWHQVLW\SURILOHVRIWKHEHDPVSRWཧ⪃ᩥ⊩>@ ᪥ᮏ䜰䜲䝋䝖䞊䝥༠఍   㝧㟁Ꮚィ 䛾⛉Ꮫ୸ၿᰴᘧ఍♫>@ 4;XHWDO J. Phys. Conf. Ser.   
>@ . 6DWR HW DO Nucl Instr Meth Phys Res %  
>@ 12VKLPDHWDOJ. Appl. Phys.   

'HYHORSPHQWRIDEULJKWQHVVHQKDQFHPHQWV\VWHPIRUWKHVORZSRVLWURQEHDPOLQHDW.85%KROH<RVKLKLUR.X]X\D1DJD\DVX2VKLPD$WVXVKL.LQRPXUD$WVXVKL<DEXXFKL.RLFKL6DWR4LX ;X
NX]X\D\RVKLKLURH#VWN\RWRXDFMS㻙 㻠㻣㻌㻙

 BNCTᐇᐇ⏝໬࡟ྥࡅࡓᶫΏࡋ◊✲㻔㻼㻶㻞㻕㸦ி኱ཎᏊ⅔ࠊி኱㝔⌮1ࠊ⸛㔝኱Ꮫ2ࠊ኱㜰་኱⬻⚄⤒3ࠊᕝᓮ་኱4ࠊ⟃Ἴ኱࣭་5ࠊ᫂἞⸆⛉኱6ࠊ኱㜰་኱࣭⭈࣭Ἢᒀჾእ⛉7ࠊᮾᕤ኱࣭⏕࿨⎔ቃ8ࠊ኱㜰ᗓ❧኱࣭⏕࿨⎔ቃ9ࠊ⚄ᡞᏛ㝔኱10ࠊරᗜ┴❧ࡀࢇࢭࣥࢱ࣮11ࠊ⟃Ἴ኱㝔ᩘ⌮12ࠊ⏘⥲◊ࢼࣀࢩࢫࢸ࣒ 13ࠊዉⰋ་኱ཱྀ࣭⭍ 14ࠊி኱㝔࣭ே㛫⎔ቃ 15ࠊᗈ኱㝔ᕤ 16ࠊ໭኱㝔་ 17ࠊᅜ❧࢞ࣥࢭࣥࢱ࣮18ࠊᗈᓥᅜ㝿኱࣭ಖ೺ 19㸧‫ۑ‬㕥ᮌ ᐇࠊ㧗ᇉ㞞⥴ 2ࠊᐑṊఙ୍ 3ࠊᖹሯ⣧୍ 4ࠊḈ஭ⱥᖾ 5ࠊᰗ⾨ᏹᐉ 6ࠊᮾ἞ே 7ࠊ୰ᮧᾈஅ 8ࠊ㇂᳃⤀἞9ࠊᏳ⸨ ᚭ10ࠊ⸨ᮏ༟ஓ 11ࠊ㛗ᓮᖾኵ 12ࠊ▼ᕝၿᜨ 13ࠊᒣᕝᘏᏹ 14ࠊᑠᯇ┤ᶞ 15ࠊ⏣୰᠇୍ 16ࠊ▼ᕝṇ⣧17ࠊ୰ᮧဴᚿ 18ࠊᯘៅ୍㑻 19㸯㸬ࡣࡌࡵ࡟
࣍࢘⣲୰ᛶᏊᤕᤊ⒪ἲ㸦Boron neutron capture therapy, ௨ୗ BNCT㸧ࡣࠊຍ㏿ჾ୰ᛶᏊ※ BNCT ↷ᑕࢩࢫࢸ࣒ࡢ㛤Ⓨᡂຌ࡟ࡼࡾࠊ㔜せ࡞㌿᥮ᮇࢆ㏄࠼࡚࠸ࡿࠋ
་Ꮫ◊✲࡛ࠕᶫΏࡋ◊✲㸦ࢺࣛࣥࢫ࣮ࣞࢩࣙࢼࣝࣜࢧ
࣮ࢳ㸧ࠖ࡜࠸࠺ゝⴥࡀ౑⏝ࡉࢀࡿࠋࡇࡢሙྜࠊᶫࡢྥࡇ࠺
࡟࠶ࡿࡢࡣࠊᢎㄆ་⒪࡛࠶ࡿࠋཎᏊ⅔ᐇ㦂ᡤ◊✲⅔㸦KUR㸧
࡛ 500 ௳ࢆ㉸࠼ࡿ BNCT ࡀᐇ᪋ࡉࢀ࡚ࡁࡓࠋࡋ࠿ࡋࠊ◊✲⅔ࡀ་⒪ᶵჾ࡜ࡋ࡚ᢎㄆࡉࢀࡿࡇ࡜ࡣ࠶ࡾ࠼࡞࠸ࠋࡑࡢⅬ
࠿ࡽࠊKUR ࢆ౑⏝ࡍࡿཎᏊ⅔ BNCT ࡣᢎㄆ་⒪࡜ࡣ࡞ࡽ࡞࠸ࠋ୍᪉ࠊୖ㏙ࡋࡓຍ㏿ჾࢆ୰ᛶᏊ※࡜ࡍࡿ↷ᑕࢩࢫࢸ࣒ࡣࠊ་⒪᪋タ࡬ࡢᑟධࡀྍ⬟࡛࠶ࡿࠋࡑࡢⅬ࠿ࡽࠊຍ㏿
ჾ BNCT ↷ᑕࢩࢫࢸ࣒ࡀᗈࡃᬑཬࡍࢀࡤࠊ
ከࡃࡢࡀࢇᝈ⪅࡟ BNCT ࢆᥦ౪࡛ࡁࡿ࡜࠸࠺ほⅬ࠿ࡽࠊຍ㏿ჾ BNCT ࡣ
ᢎㄆ་⒪࡜ࡋ࡚ㄆྍࡉࢀࡿྍ⬟ᛶࡀ࠶ࡿࠋ⌧ᅾࠊࡑࡢᢎㄆ
ࢆᚓࡿࡓࡵࡢ෌Ⓨᝏᛶ⚄⤒⭺⭘ࠊ㢌㢕㒊⭘⒆࡟ᑐࡋ࡚ࠊ᪂
つ࣍࢘⣲⸆๣࡜࠶ࢃࡏࡓ἞㦂ࡀࠊ๓⪅ࡣ 2012 ᖺ 10 ᭶࠿ࡽࠊᚋ⪅ࡣ 2014 ᖺ 4 ᭶࠿ࡽ㛤ጞࡉࢀ࡚࠸ࡿࠋຍ㏿ჾ BNCT ࡜࠸࠺ᢎㄆ་⒪ࡢࢦ࣮ࣝࡀタᐃࡉࢀ࡚ࠊึࡵ࡚ୗᅗ࡟♧ࡍ
KUR ࡢ୰ᛶᏊࢆ౑⏝ࡍࡿ BNCT ࡢᇶ♏ࠊ⮫ᗋ◊✲ࡣࠕᶫΏࡋ◊✲ࠖ࡜ᐃ⩏ࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡗࡓࠋ

BNCT ࡢ㛤Ⓨᡂຌࢆ࠺ࡅ࡚ࠊࡼࡾྛ◊✲ศ㔝ࡢ⤖ࡧࡘࡁ࡜ࠊ
ࡑࡢ◊✲㏿ᗘࢆຍ㏿ᗘⓗ࡟㐍ࡵࡿᚲせࡀ࠶ࡿࠋ⌧ᅾࠊ᪥ᮏࡢ BNCT ࢢ࣮ࣝࣉࡀࠊ
ᇶ♏◊✲ࠊ⮫ᗋ◊✲ࡢ୧㠃࡟࠾࠸࡚ࠊ
ୡ⏺ࢆ≌ᘬࡋ࡚࠸ࡿࠋࡇࡢ࣮ࣜࢻࢆࡉࡽ࡟ᣑࡆࡿࡓࡵ࡟ࡶࠊ
ᮏࣉࣟࢪ࢙ࢡࢺ◊✲ࡣព⩏ࡀ࠶ࡿ࡜⪃࠼࡚࠸ࡿࠋ ࡋ࠿ࡋࠊ2014 ᖺ 4 ᭶࠿ࡽ㛤ጞࡉࢀࡿ 3 ᖺ㛫࡟࠾࠸࡚ࠊ
KUR ࡢ㉳ືᮇ㛫ࡣࠊ2014 ᖺ 5 ᭶ࡲ࡛ࡢࠊࢃࡎ࠿ 2 ࣧ᭶㛫࡛࠶ࡗࡓࠋࡑࡢ≧ἣୗ࡛㺂2014 ᖺᗘࠊ2015 ᖺᗘ࡛ࠊ◊✲ሗ࿌ࡀࡉࢀ࡚ࡁࡓࠋࡑࡢᴫせࢆᮏ✏࡛ሗ࿌ࡍࡿࠋ᭱⤊࣏࣮ࣞ
ࢺࡣ 2016 ᖺᗘࡢሗ࿌ࢆྵࡵࡓ PROGRESS REPORT ࢆཧ↷࠸ࡓࡔࡁࡓ࠸ࠋ
㸰㸬◊✲ᡂᯝࡢᴫせPR1: ᪂つ࣍࢘⣲⸆๣ࠊ᪂つࢻࣛࢵࢢࢹࣜࣂ࣮ࣜࢩࢫࢸ࣒
ࡢᇶ♏◊✲2014 ᖺᗘ㸦5 ሗ࿌㸧࣭᥇ᢥㄢ㢟␒ྕ 26P14-18㸸 ᝏᛶ⭘⒆䛻䛚䛡䜛䝩䜴⣲୰ᛶᏊ
ᤕᤊ⒪ἲ䛻㛵䛩䜛ᇶ♏◊✲㻌 䠄㜰኱䞉ṑ䠅㻌 ከ⏣䚸௚ 10 ྡ㻌 㻌 ⏘⥲◊䛷㛤Ⓨ䛥䜜䛯᪂つ䝩䜴⣲䝘䝜໬ྜ≀䛷䛒䜛 B䠐C 䛾
BNCT 㐺⏝䛻㛵䛩䜛ᇶ♏◊✲䛷䛒䜛䚹䝚䞊䝗䝬䜴䝇䛻䝠䝖⯉⒴䛾⣽⬊ᰴ䛷⭘⒆䜢సᡂ䛧䚸B4C 䜢ᒁὀ䛧䚸୰ᛶᏊ↷ᑕᐇ㦂䜢ᐇ᪋䛧䛯䚹
B4C-BNCT ⩌ࡀ௚ࡢ 2 ᑐ↷⩌࡜ẚ㍑ࡋ࡚᭷ព࡟⭘⒆ࡢቑ
኱ࢆ㛗ᮇ㛫࡟ࢃࡓࡾไᚚࡍࡿࡇ࡜ࢆሗ࿌ࡋࡓ㹙1㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 26P14-19㸸 ᝏᛶᮎᲈᛶ⚄⤒㠧⭘࠾ࡼࡧ᫂⣽⬊⫗⭘࡟ᑐࡍࡿ࣍࢘⣲୰ᛶᏊᤕᤊ⒪ἲࡢ᳨ウ㸦රᗜ┴❧ࡀࢇࢭࣥࢱ࣮㸧⸨ᮏࠊ௚ 5 ྡࣄࢺ᫂⣽⬊⫗⭘ࡢ⣽⬊ᰴࢆࠊࢾ࣮ࢻ࣐࢘ࢫࡢ⫵࡟ᒁὀࡍࡿࡇ࡜࡟ࡼࡾ⫵㌿⛣ࣔࢹ࣐ࣝ࢘ࢫࢆసᡂࡋࠊ඲⫵ࢆ↷ᑕࡍࡿ୰ᛶᏊ↷ᑕᐇ㦂ࢆᐇ᪋ࡋࡓࠋࡑࡢ⤖ᯝࠊBNCT ⩌ࡢࡳ⭘⒆ࢆ㔜⠜࡞᭷ᐖ஦㇟࡞ࡋ࡟⦰ᑠࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓ
㹙2-4㹛ࠋ

 ᮏࣉࣟࢪ࢙ࢡࢺ◊✲ࡣࠊୖᅗ࡛♧ࡍ࡜ࡇࢁࡢ㺂㠀⮫ᗋ◊✲࡜἞㦂እ་ᖌ⮬୺⮫ᗋ◊✲㸦ཎᏊ⅔ BNCT㸧࠿ࡽᵓᡂࡉ
ࢀࡿࠋ௨ୗ࡟㸱ࡘࡢ◊✲㡯┠㸦PR1-3㸧ࢆ♧ࡍࠋ
PR1: ᪂つ࣍࢘⣲⸆๣ࠊ᪂つࢻࣛࢵࢢࢹࣜࣂ࣮ࣜࢩࢫࢸ
࣒ࡢᇶ♏◊✲㸦⣽⬊ࠊᢸ⒴ື≀ࡢ↷ᑕᐇ㦂ࡀ୰ᚰ㸧
PR2: BNCT ࡟࠿࠿ࢃࡿ་Ꮫ≀⌮◊✲PR3: KUR ࢆ⏝࠸ࡓ་ᖌ୺ᑟࡢ BNCT ⮫ᗋ◊✲᭱⤊ࢦ࣮࡛ࣝ࠶ࡿ BNCT ࡢᢎㄆ་⒪ࢆ┠ᣦࡋࠊࡇࢀࡽࠊ
㸱ࡘࡢ◊✲ศ㔝ࢆࠊ㸯ࡘࡢ኱ࡁ࡞࣋ࢡࢺࣝࢆᣢࡗ࡚ࠊ᭷ᶵ
ⓗ࡟⤖ࡧࡘࡅ࡚㐍ࡵ࡚࠸ࡃᚲせࡀ࠶ࡿࠋ⌧ᅾࡲ࡛ࡶࠊࡇࡢ
㸱ศ㔝ࡢඹྠ฼⏝◊✲ࡀ⢔ࠎ࡜㐍ࡵࡽࢀ࡚ࡁࡓࡀࠊຍ㏿ჾ㻙 㻠㻤㻌㻙

࣭᥇ᢥㄢ㢟␒ྕ 26P14-22㸸 ୰ᛶᏊᤕᤊ⒪ἲࡢ୍⯡እ⛉㡿ᇦ㞴἞ᛶ⒴࡬ࡢᛂ⏝࡟ྥࡅࡓ DDS ࡢᇶ♏ⓗ◊✲ 㸦᫂⸆኱㸧ᰗ⾨ࠊ௚ 12 ྡ ࣍࢘⣲⸆๣ BSH ࢆ water-in-oil-in-water (WOW)emulsionࢆ⸆๣฿㐩ࡢᢸయ࡜ࡍࡿ᪂つ Drug delivery system ࡢᇶ♏
◊✲ࢆᐇ᪋ࡋࡓࠋVX-2 ⫢⭘⒆ࢆᐙඡ࡟⛣᳜ࡋࠊ⫢ື⬦࠿ࡽ BSH-WOW emulsion ࢆ ᢞ ୚ ࡋ ࠊ ⫢ ⭘ ⒆࡟ 㑅 ᢥ ⓗ ࡟
emulsion ࡀ㞟✚ࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓࠋ
࣭᥇ᢥㄢ㢟␒ྕ 26P14-20㸸㧗࠸⭘⒆㑅ᢥᛶࢆ᭷ࡍࡿ࣎ࣟ
ࣥ໬ྜ≀ࢼࣀ⢏Ꮚࡢ๰〇࡜୰ᛶᏊᤕᤊ⒪ἲ࡬ࡢᒎ㛤 㸦⟃Ἴ኱㝔࣭ᩘ⌮㸧㧗㺂௚6ྡ ࣍࢘⣲ࢡࣛࢫࢱ࣮࡜άᛶ㓟⣲㸦ROS㸧ࡢ scavenger ࢆ⤌ࡳྜࢃࡏࡓ᪂つ࣍࢘⣲ࢼࣀ⸆๣ࢆ㛤Ⓨࡋࠊᢸ⒴࣐࢘ࢫ࡟ᢞ

୚ࡋ୰ᛶᏊ↷ᑕᐇ㦂ࢆᐇ᪋ࡋࡓࠋࡑࡢ⤖ᯝࠊ᪂つ࣍࢘⣲ࢼࣀ⸆๣࡛ࡢ %1&7 ↷ᑕ⩌ࡣࠊ⭘⒆⦰ᑠຠᯝ࡜ࠊ%3$%1&7⩌࡛ほᐹࡉࢀࡓ⅖⑕ࢆ♧၀ࡍࡿⓑ⾑⌫ቑຍࡀ♧ࡉࢀ࡞࠿ࡗࡓ㹙㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 3㸸୰ᛶᏊᤕᤊ⒪ἲࡢࡓࡵࡢ᪂つ࣍࢘⣲⸆๣ࡢ㛤Ⓨ㸦ᮾᕤ኱࣭㈨※◊㸧୰ᮧࠊ௚ྡ
㧗⃰ᗘࡢ࣍࢘⣲ྵ᭷ࡢ࣏ࣜࢯ࣮࣒సᡂ࡟࠶ࡓࡾࠊ࢝࢘ࣥ
ࢱ࣮࢝ࢳ࢜ࣥ࡜ࡋ࡚ VSHUPLGLQLXP ࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊ
㧗࠸཰⋡㸦㸣㸧࠿ࡘ SSP ࡢ࣍࢘⣲⃰ᗘࡢ࣏ࣜࢯ࣮
࣒ࢆసᡂ࡟ᡂຌࡋࡓࠋࡲࡓࠊᢸ⒴࣐࢘ࢫ࡟ᢞ୚ࡋ㺂ᢠ⭘⒆ຠᯝࡶ☜ㄆࡋࡓ㹙㹛ࠋ ᖺᗘ㸦 ሗ࿌㸧࣭᥇ᢥㄢ㢟␒ྕ 3㸸୰ᛶᏊᤕᤊ⒪ἲࡢ୍⯡እ⛉㡿ᇦ㞴἞ᛶ⒴࡬ࡢᛂ⏝࡟ྥࡅࡓ ''6 ࡢᇶ♏ⓗ◊✲ 㸦᫂⸆኱㸧ᰗ⾨ࠊ௚  ྡ
 %6+:2:HPXOVLRQ ࡢᐙඡࡢ⫢⭘⒆࡬ࡢ㞟✚ࢆ  ✀ࡢ⏺
㠃άᛶ๣ࢆ⏝࠸࡚ࠊືὀ  ᪥ᚋࠊ ᪥ᚋࠊ ᪥ᚋ࡜⫢⭘⒆ࠊ
ṇᖖ⫢㺂⾑ᾮࡢ࣍࢘⣲⃰ᗘࢆ ᐃࡋࡓࠋᢞ୚ࠊ ᪥ࠊ ᪥┠࡛ࠊ⭘⒆ෆ࡟㑅ᢥᛶࢆࡶࡗ࡚㧗࠸㞟✚ࡀ᭷ࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋ
35 %1&7 ࡟࠿࠿ࢃࡿ་Ꮫ≀⌮◊✲ ᖺᗘ  ሗ࿌࣭᥇ᢥㄢ㢟␒ྕ3 %1&7 ࡟࠾ࡅࡿ྾཰⥺㔞ศᕸᐃࡢࡓࡵࡢ࣏࣐࣮ࣜࢤࣝ ḟඖ⥺㔞ィࡢ㛤Ⓨ࡜≉ᛶホ౯ᗈᅜ኱࣭ಖ೺་⒪  ᯘࠊ௚ྡ ᶆ ‽ ⓗ ࡞ ࣏ ࣜ ࣐ ࣮ ࢤ ࣝ ࡛ ࠶ ࡿ PHWKDF\OLFDFLGEDVHGSRO\PHUJHO 0$*$7 ࢆ࣍࢘⣲௜ຍࡢ᭷↓࡛ࠊ୰ᛶᏊ↷ᑕ࡟
ࡼࡿ㔜ྜ཯ᛂࢆ 05, ࡢ WUDQVYHUVH UHOD[DWLRQ UDWH R
T ࡟ࡼࡾホ౯ࡋࡓࠋࡑࡢ⤖ᯝࠊ࣎ࣟࣥ௜ຍࡢࢤࣝࡢ㔜ྜ཯ᛂࡣ⇕୰ᛶᏊࡢศᕸ࡟┦㛵ࡋ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞
ࡗࡓࠋ࣭᥇ᢥㄢ㢟␒ྕ3㹀㹌㹁㹒⏝↷ᑕሙ࡟࠾ࡅࡿ㟁㞳⟽࠾ࡼࡧ࣎ࢼ࣮࣮࣎ࣝࢆ⏝࠸ࡓ㹏㸿㸭㹏㹁ࡢ☜❧ ி኱
ཎᏊ⅔  Ḉ஭ࠊୖ⏣ࠊ௚ྡ
࣎ࢼ࣮⌫ࢆ⏝࠸ࡓࢫ࣌ࢡࢺࣝホ౯ࢆ⾜࠺ሙྜࠊ⌫ෆ࡟ධࢀࡿ᳨ฟჾࡢ఩⨨ࡢࡎࢀ ࡇࡇ࡛ࡣsPP ࡶ⪃៖ࡋ࡚ࢫ࣌ࢡࢺࣝホ౯ࢆࡍࡿ᪉ࡀࠊࢫ࣌ࢡࢺࣝࡢᙧ≧࡟ࡘ࠸࡚ࡣࡼࡾ
ṇ☜࡞⤖ᯝࡀᚓࡽࢀࡿࡀࠊ⤯ᑐ್࡟ࡘ࠸࡚ࡣㄗᕪࡀ኱ࡁࡃ
࡞ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ㹙㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 3 ࢖࣓࣮ࢪࣥࢢࣉ࣮ࣞࢺࢆ⏝࠸ࡓ
%1&7 ↷ᑕሙࣅ࣮࣒ᡂศࡈ࡜ࡢ  ḟඖศᕸရ㉁ಖド ᗈᓥ኱࣭ᕤ  ⏣୰ࠊ௚  ྡ
 %1&7 ࡟౑⏝ࡉࢀࡿ୰ᛶᏊࣅ࣮࣒ࡢࢥ࣏࣮ࣥࢿࣥࢺ࡛
࠶ࡿ⇕୰ᛶᏊࠊ⇕እ୰ᛶᏊࠊ㧗㏿୰ᛶᏊࠊȖ ⥺ࡢᡂศࢆᘚูࡋ࡚ ᐃࡍࡿ 7ZLQ ,PDJLQJ 3ODWH ,3 ࢩࢫࢸ࣒ࢆ⪃᱌ࡋ࡚ࠊࡑࡢィ⟬⤖ᯝࢆሗ࿌ࡋࡓࠋ
࣭᥇ᢥㄢ㢟␒ྕ 3%1&7 ࡢࡓࡵࡢ༶Ⓨ࣐࢞ࣥ⥺࡟ࡼࡿࣜ࢔ࣝࢱ࢖࣒⥺㔞ホ౯ࢩࢫࢸ࣒࡟㛵ࡍࡿ◊✲㸦ி኱࣭
ཎᏊ⅔㸧⏣୰ࠊ௚  ྡ
 %1& ↷ᑕ୰࡟ࠊᝈ⪅࠿ࡽࡢ༶Ⓨ Ȗ ⥺ࢆ ᐃࡍࡿࢩࢫࢸ࣒
㛤Ⓨࡢ᭱኱ࡢ㞀ቨࡣࠊ↷ᑕᐊෆࡢ Ȗ ⥺ࡢࣂࢵࢡࢢࣛࣥࢻࡀ
㧗࠸ࡇ࡜࡛࠶ࡿࠋࢩࢫࢸ࣒㛤Ⓨ࡟ᙜࡓࡾࠊ↷ᑕᐊࡢ Ȗ ⥺ࡢศᕸࢆホ౯ࡋࡓࠋࡑࡢ⤖ᯝࢥ࣓࣮ࣜࢱ࣮ࡢ⫼ഃ࡟እഃ࡟ྥ㻙 㻠㻥㻌㻙

࠿ࡗ࡚ࣔࢽࢱ࣮ࢆ㓄⨨ࡍࡿࡇ࡜ࡀ᭱ࡶᮃࡲࡋ࠸ࡇ࡜ࡀ᫂
ࡽ࠿࡟࡞ࡗࡓࠋ
 ᖺᗘ㸦 ሗ࿌㸧᥇ᢥㄢ㢟␒ྕ 3 %1&7 ࡟࠾ࡅࡿ྾཰⥺㔞ศᕸᐃࡢࡓࡵࡢ࣏࣐࣮ࣜࢤࣝ ḟඖ⥺㔞ィࡢ㛤Ⓨ࡜≉ᛶホ౯ᗈᅜ኱࣭ಖ೺་⒪  ᯘࠊ௚ྡ
 %1&7 ࡢࢤࣝ⥺㔞ィ࡜ࡋ࡚ࠊ/L ࢆ㈇Ⲵࡍࡿᇶ♏◊✲ࢆ ;⥺↷ᑕ࡟ࡼࡾᐇ᪋ࡋࡓࠋࡑࡢ⤖ᯝࠊ/L&O/L62 ࡀೃ⿵࡜࡞
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
࣭᥇ᢥㄢ㢟␒ྕ 3㸸%1&7⏝↷ᑕሙ࡟࠾ࡅࡿ㟁㞳⟽࠾ࡼࡧ࣎ࢼ࣮࣮࣎ࣝࢆ⏝࠸ࡓ4$㸭4&ࡢ☜❧ ி኱ཎᏊ⅔  Ḉ஭ࠊ௚ྡ
%1&7 ࡢ 4$4& ࢩࢫࢸ࣒࡜ࡋ࡚ࠊ୰ᛶᏊࡢ࢚ࢿࣝࢠ࣮
ࢫ࣌ࢡࢺ࣒ࣛࡢ ᐃ࡟ࠊከᒙᛶࡢ࣎ࢼ࣮࣮࣎ࣝࢆ⪃᱌ࡋࡓࠋ᭱㐺໬ィ⟬ࢆ⾜࠸ࠊ ᒙᛶࡢ࣎ࢼ࣮࣮࣎ࣝࢆᥦ᱌ࡋࡓ㹙㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 3㸸࢖࣓࣮ࢪࣥࢢࣉ࣮ࣞࢺࢆ⏝࠸
ࡓ%1&7 ↷ᑕሙࣅ࣮࣒ᡂศࡈ࡜ࡢ ḟඖศᕸရ㉁ಖドᗈᓥ኱࣭ᕤ  ⏣୰ࠊ௚㸴ྡ ᖺᗘ࡟ᘬࡁ⥆ࡁࠊ7ZLQ,PDJLQJ3ODWH ,3 ࢩࢫࢸ࣒ࡢ᳨ウࢆ⾜ࡗࡓࠋ୰ᛶᏊࣅ࣮࣒ࡢྛࣅ࣮࣒ࢥ࣏࣮ࣥࢿࣥࢺ࡜
,3 ࢩࢢࢼࣝࡢ┦㛵࡟ࡘ࠸࡚ࠊ࢚ࢿࣝࢠ࣮࡜ῶ⾶᫬㛫࡟╔┠ࡋ᳨࡚ウࡋࡓ㹙㹛ࠋ
35 .85 ࢆ⏝࠸ࡓ་ᖌ୺ᑟࡢ %1&7 ⮫ᗋ◊✲ ᖺᗘ㸦 ሗ࿌㸧࣭᥇ᢥㄢ㢟␒ྕ 3 㢌㢕㒊ᝏᛶ⭘⒆࡟࠾ࡅࡿ࣍࢘⣲୰ᛶᏊᤕᤊ⒪ἲࡢ⮫ᗋⓗ◊✲㸦㜰኱㸰ཱྀእ㸧ຍ⸨ࠊ௚ ྡ ྡࡢ௚ࡢ἞⒪ᡭẁࡀ࡞࠸㢌㢕㒊⭘⒆ࡢ⑕౛࡟ᑐࡋ࡚
%1&7 ࢆᐇ᪋ࡋࡓ⤖ᯝࢆሗ࿌ࡋࡓࠋᒁᡤຠᯝࡣࠊ&5353'ࡀࡑࢀࡒࢀࠊ ౛ࠊ ౛ࠊ ౛࡛࠶ࡗࡓ㹙㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 3 ⇕እ୰ᛶᏊࢆ⏝࠸ࡓᝏᛶ⬻⭘⒆࡟ᑐࡍࡿ㠀㛤㢌୰ᛶᏊᤕᤊ⒪ἲࡢ⮫ᗋⓗ◊✲㸦኱་኱࣭⬻እ㸧ᐑṊࠊ௚  ྡ  ᖺ  ᭶࠿ࡽ  ᭶ࡢ㛫ࠊ ౛ࡢ %1&7 ࢆᐇ᪋ࡋࡓࠋ
ࡑࡢෆヂࡣࠊ෌Ⓨ⭺ⱆ⭘  ౛ࠊ෌Ⓨ㏥ᙧᡂᫍ⣽⬊⭘  ౛ࠊᝏᛶ㧊⭷⭘  ౛ࠊ㢌㢕㒊⭘⒆  ౛ࠊ㢌⵹㦵⫗⭘  ౛࡛࠶ࡗࡓࠋ㢌⵹㦵࡟Ⓨ⏕ࡋࡓ㦵⫗⭘࡟ᑐࡍࡿ %1&7 ࡣࠊ≉࡟᭷ᐖ஦㇟࡞ࡃ⭘⒆ࢆ๻ⓗ࡟⦰ᑠࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓ㹙㹛ࠋ࣭᥇ᢥㄢ㢟␒ྕ 3 ୰ᛶᏊᤕᤊ⒪ἲࡢ୍⯡እ⛉㡿ᇦ㞴἞ᛶ⒴࡬ࡢᒎ㛤࡟ྥࡅࡓ⮫ᗋⓗ◊✲㸦᫂⸆኱㸧ᰗ⾨ࠊ௚ ྡ ྑங⒴⾡ᚋ࡟ࠊྑ㙐㦵ୖ❐ࣜࣥࣃ⠇㌿⛣ࢆ᭷ࡍࡿ⑕౛࡟
)%3$3(7 ᳨ᰝࢆᐇ᪋ࡋࡓࠋ⭘⒆⾑ᾮࡢ࣍࢘⣲⃰ᗘࡢ㞟✚ẚࡣ  ࡛࠶ࡗࡓࠋࡇࡢࢹ࣮ࢱࢆࡶ࡜࡟἞⒪ィ⏬ࢆᐇ᪋ࡍࡿ࡜ࠊ ศࡢ↷ᑕ᫬㛫࡛ࠊࣜࣥࣃ⠇㌿⛣ࡢ⭘⒗࡟ᑐࡋ࡚㺂᭱኱ࠊ᭱ᑠࠊᖹᆒ⥺㔞ࡣࠊ*\(T ࡛࠶ࡗࡓ㹙㹛ࠋ ᖺᗘ  ሗ࿌࣭᥇ᢥㄢ㢟␒ྕ 3 ங⒴࡟ᑐࡍࡿ◹⣲୰ᛶᏊᤕᤊ⒪ἲࡢ᳨ウ㸦රᗜ┴ࡀࢇࢭࣥࢱ࣮㸧⸨ᮏࠊ௚  ྡ ங⒴ࡢᕥ⭆❐ࣜࣥࣃ⠇㌿⛣࡟ᑐࡍࡿ %1&7 ࡢ⑕౛ࢆሗ
࿌ࡋࡓࠋᝈ⪅ࢆⱞࡋࡵ࡚࠸ࡓᙉ࠸③ࡳࡀࠊ%1&7 ᐇ᪋ᚋࠊ᪩ᮇ࡟ᾘኻࡋࠊ⏬ീୖࡶ⭘⒆ࡢ⦰ᑠࡀ☜ㄆࡉࢀࡓࠋ

࣭᥇ᢥㄢ㢟␒ྕ 3㸸 ୰ᛶᏊᤕᤊ⒪ἲࡢ୍⯡እ⛉㡿ᇦ㞴἞ᛶ⒴࡬ࡢᒎ㛤࡟ྥࡅࡓ⮫ᗋⓗ◊✲㸦᫂⸆኱㸧ᰗ⾨ࠊ௚ ྡ
ங⒴⑕౛ࡢ⏬ീࢆ἞⒪ィ⏬⿦⨨࡟࡜ࡾࡇࡳࠊ ࡘࡢ↷ᑕ᪉ἲࡢ⥺㔞ศᕸࢆẚ㍑ࡋࡓࠋࡑࡢ⤖ᯝࠊ ᪉ྥ࠿ࡽࡢ↷ᑕࡀ㺂⭘⒆࡟ࡼࡾ㧗࠸⥺㔞ࢆ↷ᑕࡀྍ⬟࡛࠶ࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋ
ࡓࠋཧ⪃ᩥ⊩㹙㹛7,ZDJDPLet al. -1XFO0HG5DGLDW7KHU  㹙㹛7$QGRKet al. $SSO5DGLDW,VRW  
㹙㹛7$QGRKet al. $SSO5DGLDW,VRW  
㹙㹛7)XMLPRWRet al. $SSO5DGLDW,VRW  
㹙㹛=*DRet al., %LRPDWHULDOV  
㹙㹛67DFKLNDZDet al. &KHP&RPPXQ &DPE   
㹙㹛+8HGDet al. $SSO5DGLDW,VRW  
㹙㹛<6DNXUDLet al.0HG3K\V  
㹙㹛+8HGDet al. $SSO5DGLDW,VRW  
㹙㹛.7DQDNDet al. $SSO5DGLDW,VRW  
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ࣕࣝ⤖ᬗᡂ㛗ࡀ㉳ࡁࡿⅬ࡛ࡣྠࡌ࡛࠶ࡿࡀࠊ㟁Ꮚࣅ࣮࣒ࡢሙྜࡣࠊ࢖࢜ࣥࣅ࣮࣒࡜ࡣ␗࡞ࡾᐊ ௨ୗ࡛ࡶ⤖ᬗᡂ㛗ࡀほ ࡉࢀࠊࡑࡢάᛶ໬࢚ࢿࣝࢠ࣮ࡶ࢖
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㟁Ꮚ㸧ࢆ⤖ᬗᮦᩱ㸦༢⤖ᬗࡲࡓࡣከ⤖ᬗᮦᩱ㸧࡟↷ᑕࡍࡿ࡜ཎᏊࡢᙎࡁฟࡋࢆ㉳ࡇࡋ࡚ࠊ᱁ᏊḞ㝗ࢆᙧᡂࡋᮦᩱࡢ≉ᛶ࡟ᙳ㡪ࢆ୚࠼ࡿࠋᮦᩱ୰࡟ᙧᡂࡉࢀ
ࡿᙎࡁฟࡋཎᏊᩘࡣࠊ㧗࢚ࢿࣝࢠ࣮⢏Ꮚࡢ↷ᑕ᮲௳࠿ࡽṇ☜࡟ィ⟬ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡀࠊᐇ㝿࡟↷ᑕᚋࡢ⤖ᬗᮦᩱ୰࡟ṧ␃ࡍࡿኚ఩ཎᏊᩘࢆㄪ࡭ࡿ࡜ࠊィ⟬࡛ồࡵࡓᙎࡁฟࡋཎᏊᩘࡼࡾࡶᑡ࡞࠸ࡇ࡜ࡀᗈࡃ
▱ࡽࢀ࡚࠸ࡿࠋࡇࢀࡣࠊཎᏊࡢᙎࡁฟࡋ࡛ᙧᡂࡉࢀ
ࡿⅬḞ㝗㸦ཎᏊ✵Ꮝ࡜᱁Ꮚ㛫ཎᏊ㸧ࡢ෌⤖ྜᾘ⁛ࢆྵࡵ࡚ࠊ⤖ᬗᛶࡢᅇ᚟㸦᱁ᏊḞ㝗ࡢ⦰ᑠࠊᾘ⁛㸧ࡀ㉳ࡁ࡚࠸ࡿࡇ࡜ࢆ♧ࡋ࡚࠸ࡿࠋ ᐇ㝿࡟ࠊࢩࣜࢥࣥ༢⤖ᬗ࡞࡝࡟ணࡵ࢖࢜ࣥ↷ᑕ࡛ᙧᡂࡋࡓ↷ᑕᦆയᒙ࡟␗࡞ࡿ᮲௳࡛㏣ຍ࢖࢜ࣥ↷ᑕࢆ⾜࠺ࡇ࡜࡟ࡼࡾࠊ↷ᑕᦆയᒙࡀ⦰ᑠࡍࡿ⌧㇟ࡀほࡉࢀ࡚࠸ࡿࠋࡇࡢ⌧㇟ࡣ࢖࢜ࣥࣅ࣮࣒࢔ࢽ࣮ࣜࣥ
ࢢ࡜ࡋ࡚▱ࡽࢀ࡚࠸ࡿࠋ)LJ D ࡟࢖࢜ࣥࣅ࣮࣒࢔
ࢽ࣮ࣜࣥࢢࡢᴫᛕᅗࢆ♧ࡍࠋ࢖࢜ࣥࣅ࣮࣒࢔ࢽ࣮ࣜ
ࣥࢢࡼࡾࡶࡉࡽ࡟⤖ᬗᛶᅇ᚟ࡀ㢧ⴭ࡟⌧ࢀࡿࡢࡀ࢖
࢜ࣥࣅ࣮࣒ㄏ㉳⤖ᬗᡂ㛗࡛࠶ࡿ>@ࠋ)LJ E ࡟♧ࡍࡼ࠺࡟ࠊࢩࣜࢥࣥ༢⤖ᬗ୰࡟࢖࢜ࣥ↷ᑕ࡞࡝࡟ࡼࡾ
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⤖ᬗᡂ㛗ࡀㄏ㉳ࡉࢀࠊ㠀ᬗ㉁ᒙࡀ⦰ᑠࡋࠊ⤖ᬗᛶᅇ᚟ࡀ㉳ࡁࡿࠋ ࡉࡽ࡟ࠊ࢖࢜ࣥࣅ࣮࣒ㄏ㉳⤖ᬗᡂ㛗ࡀ㉳ࡁࡿ᮲௳࡛ࠊᇶᯈ ᗘࢆୗࡆ࡚࠸ࡃ࡜ࠊ㠀ᬗ㉁࣭༢⤖ᬗ⏺㠃ࡢ⛣ື㸦࢚ࣆࢱ࢟ࢩࣕࣝ⤖ᬗᡂ㛗㸧ࡀ㉳ࡁ࡞࠸ ᗘࡀᏑᅾࡋࠊࡑࡢ ᗘࢆୗᅇࡿ࡜ࠊ࠶ࡓ࠿ࡶ㈇ࡢ⤖ᬗᡂ㛗ࡢࡼ࠺࡟ OD\HUE\OD\HU ࡛㠀ᬗ㉁ᒙࡢཌࡳࡀ
ቑࡋ࡚࠸ࡃ⌧㇟ࡀほ ࡉࢀࡿࠋࡇࢀࡣ࢖࢜ࣥࣅ࣮࣒
ㄏ㉳㠀ᬗ㉁໬࡜࿧ࡤࢀࠊ⇕ບ㉳ࡔࡅࡣ㉳ࡁ࡞࠸⌧㇟࡛࠶ࡿࠋࡇࡢࡼ࠺࡞⌧㇟ࡀほ ࡉࢀࡿࡇ࡜ࡣࠊᮦᩱ
⛉ᏛࡢほⅬ࠿ࡽ㠀ᖖ࡟⯆࿡῝࠸ࠋ࢖࢜ࣥ↷ᑕ࡟ࡼࡾ⤖ᬗᛶᅇ᚟ࡢ࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡓࡵ࡟ᵝࠎ࡞◊✲ࡀ⾜ࢃࢀ࡚ࡁࡓࡀࠊࡑࡢ⌮ゎࡣ㐍ࢇ࡛࠸࡞࠸ࠋ≉࡟࢖࢜ࣥࣅ࣮࣒ㄏ㉳⤖ᬗᡂ㛗࡟ࡘ࠸࡚ࡣࡑࡢ⌧㇟ࡢ≉␗ࡉࡸᛂ⏝㠃ࡢ㔜せᛶ࠿ࡽࠊከࡃࡢ◊✲ࡀ⾜ࢃࢀࠊ⌧㇟ࢆᐃᛶⓗ࡟グ㏙࡛ࡁࡿࡼ࠺࡞ࣔࢹࣝࡢᵓ⠏ࡀヨࡳࡽࢀࡓࡀࠊࡲࡔᡂຌࡋ࡚࠸
࡞࠸ࠋ౛࠼ࡤࠊ࢖࢜ࣥࣅ࣮࣒ㄏ㉳⤖ᬗᡂ㛗࡟ࡣ ᗘ౫Ꮡᛶࡀ࠶ࡾࠊ⤖ᬗᡂ㛗㏿ᗘࡢ ᗘ౫Ꮡᛶࡢ࢔ࣞࢽ
࢘ࢫࣉࣟࢵࢺࢆసᡂࡍࡿ࡜ࠊࡑࡢഴࡁ࠿ࡽ཯ᛂࡢᚊ
㏿ẁ㝵࡜࡞ࡿάᛶ໬࢚ࢿࣝࢠ࣮ࡀ⟬ฟ࡛ࡁࡿ࡜㛗ࡃ⪃࠼ࡽࢀ࡚ࡁࡓࠋࡑࡢࡼ࠺࡞⪃࠼᪉ࡢ⫼ᬒ࡟ࡣࠊ཯
ᛂࡢᚊ㏿ẁ㝵ࡣ୍ࡘ࡛࠶ࡾࠊ༢୍ࡢάᛶ໬࢚ࢿࣝࢠ࣮ࡀほ ࡉࢀࡿࡇ࡜ࢆ௬ᐃࡋ࡚࠸ࡿࠋࡋ࠿ࡋࠊ㐣ཤ
࡟Ⓨ⾲ࡉࢀࡓᐇ㦂⤖ᯝ࠿ࡽᚓࡽࢀࡿάᛶ໬࢚ࢿࣝࢠ
࣮࡟ࡣᖜࡀ࠶ࡾࠊᚲࡎࡋࡶ༢୍ࡢ್ࡀᚓࡽࢀ࡚࠸࡞
࠸ࠋࡑࡢᚋࠊ」ᩘࡢ࢖࢜ࣥ✀ࢆ⏝࠸࡚⾜ࡗࡓ⣔⤫ⓗ

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ࢺࣝ㸦ᐇ⥺㸧ࠊ༢⤖ᬗࡢࢫ࣌ࢡࢺࣝ㸦Ⅼ⥺㸧ࡀࣉࣟࢵࢺࡉࢀ࡚࠸ࡿࠋ⇕ฎ⌮ࡢࡳࡢヨᩱ࡟ࡘ࠸࡚ࡣࠊ୰ᛶ
Ꮚ↷ᑕ᫬㛫࡜ ᗘࡀྠࡌ࡟࡞ࡿᵝ࡟㟁Ẽ⅔࡛⇕ฎ⌮ࡋ࡚࠸ࡿࠋᶓ㍈ࡣ࢚ࢿࣝࢠ࣮࡛࠶ࡿࡀࠊ⾲㠃࠿ࡽࡢ῝ࡉ࡟ᑐᛂࡍࡿ㸦῝࠸㒊ศ࡯࡝ᩓ஘࢖࢜ࣥࡢ࢚ࢿࣝ
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ࠋࣛࣥࢲ࣒ࢫ࣌ࢡࢺࣝࡣ㠀ᬗ㉁ࣞ࣋ࣝࢆ
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യࢆཷࡅ࡚࠸ࡿࡀࠊ⇕ฎ⌮ࡔࡅ࡛ࡶࠊ༢⤖ᬗ࡟㏆࠸ࣞ࣋ࣝࡲ࡛ᅇ᚟ࡀ㉳ࡁࡿࠋࡋ࠿ࡋࠊ୰ᛶᏊ↷ᑕヨᩱࡣ⇕ฎ⌮ࡔࡅࡢሙྜࡼࡾࡶࡉࡽ࡟⤖ᬗᛶᅇ᚟ࡀ㐍ࢇ࡛࠸ࡿࡇ࡜ࡀ♧ࡉࢀࡓࠋࡇࡢࡇ࡜࠿ࡽࠊ࢖࢜ࣥࣅ࣮
࣒࢔ࢽ࣮ࣜࣥࢢ࡜ྠ➼ࡢ⌧㇟ࡀ୰ᛶᏊ↷ᑕ࡛ࡶほࡉࢀࡿࡇ࡜ࡀศ࠿ࡗࡓࠋ ࡉࡽ࡟ࠊ FP ↷ᑕヨᩱ࡟ᑐࡋ࡚ࡶ Υ୰ᛶᏊ↷ᑕࢆ⾜࠸ 5%6& ᐃࢆᐇ᪋ࡋࡓࠋᮏሗ࿌࡟ࡣ
ࢹ࣮ࢱࡣ♧ࡉ࡞࠸ࡀࠊヨᩱ୰࡟ᙧᡂࡉࢀࡓ㠀ᬗ㉁ᒙ
ࡢ୧➃࡛ⱝᖸࡢ⤖ᬗᛶᅇ᚟ࡀぢࡽࢀࡓࠋࡋ࠿ࡋࠊࡇ
ࢀࡣ࢖࢜ࣥࣅ࣮࣒ㄏ㉳⤖ᬗᡂ㛗ࡢࡼ࠺࡞࢚ࣆࢱ࢟ࢩ

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GDPDJHSHDNVDIWHUWKHUPDODQQHDOLQJDQGQHXWURQLUUDGLDWLRQ DWR&<,(/' FRXQWV&] ᡂ㛗ࡢ  㠃༢⤖ᬗࢩࣜࢥࣥࢆ⏝࠸ࡓࠋணࡵ↷ᑕᦆയᒙࢆᑟධࡍࡿࡓࡵ࡟ࠊNH9 6L ↷ᑕࢆᐊ ࡛⾜ࡗࡓࠋ↷ᑕ㔞ࡣ ࠊࠊ FP ࡢ ㏻ࡾ࡜ࡋࡓࠋࢩࣜࢥࣥ࡬ࡢ࢖࢜ࣥ↷ᑕ࡛ࡣࠊ↷ᑕ㔞ࡀ࠶ࡿࡋࡁ࠸್ࢆ㉸࠼ࡿ࡜ᛴ⃭࡟㠀ᬗ㉁໬ࡀ㐍ࡴࡀࠊ↷ᑕ㔞  FP ࡣࠊ㠀ᬗ㉁໬ࡢࡋࡁ࠸್ࢆୗᅇࡗ
࡚࠾ࡾࠊ⤖ᬗᛶࡢṧࡗࡓ㔜ᦆയ㡿ᇦ࡛࠶ࡿࠋࡑࢀࡼ
ࡾ↷ᑕ㔞ࡢከ࠸ ࠊ FP ࡢሙྜࡣࠊ㠀
ᬗ㉁໬ࡀ㉳ࡁࡿ㡿ᇦ࡛࠶ࡿࠋ ୰ᛶᏊ↷ᑕࡣி㒔኱Ꮫ◊✲⏝ཎᏊ⅔ .85 ࢆ⏝࠸࡚௨ୗࡢ஧ࡘࡢ↷ᑕタഛ࡟ࡼࡾ⾜ࡗࡓࠋձ⢭ᐦไᚚ↷ᑕ⟶ .85666 㸸୰ᛶᏊ⥺㔞ࡣ  QFPV ࡛ࠊヨᩱ ᗘࢆ Υ࡟ಖᣢࡋ࡞ࡀࡽ
0: 㐠㌿࡛  㐌㛫㸦K㸧ࡢ↷ᑕࢆ⾜ࡗࡓ>@ࠋղ㛗ᮇ↷ᑕタഛ㸦⅔ᚰ↷ᑕタഛ㸧㸸୰ᛶᏊ⥺㔞ࡣ  QFPV ࡛ࠊ ᗘไᚚࢆ⾜ࢃࡎ 0: 㐠㌿࡛ 㐌㛫㸦 㐌࠶ࡓࡾ⣙ K ࡢ↷ᑕࢆ⾜ࡗࡓࠋ↷ᑕ ᗘ࡟ࡘ࠸࡚ࡣࠊ㐣ཤࡢᙧ≧グ᠈ྜ㔠ࢆ౑ࡗࡓᐇ ࡸ⇕ᣑᩓ᪉⛬ᘧ࡟ࡼࡿィ⟬࡞࡝࠿ࡽࠊ↷ᑕᦆയᒙ࡟୚࠼
ࡿᙳ㡪ࡀᑠࡉ࠸ Υ௨ୗ࡛࠶ࡿࡇ࡜ࡀ☜ㄆࡉࢀ࡚࠸
ࡿ>@ࠋ࢖࢜ࣥ↷ᑕᦆയࡢィ⟬ࡣ 75,0 ࢥ࣮ࢻ㸦⌧ᅾࡣ 65,0ࢥ࣮ࢻ㸧࡛ࠊ୰ᛶᏊ↷ᑕᦆയࡢィ⟬ࡣ 63(&7(5 ࢥ࣮ࢻ࡛⾜ࡗࡓࠋ ↷ᑕᚋࡢヨᩱࡣࢳࣕࢿࣜࣥࢢࢆే⏝ࡋࡓࣛࢨࣇ࢛
࣮ࢻᚋ᪉ᩓ஘ἲ 5%6& ࢆ⏝࠸࡚ホ౯ࡋࡓࠋⱝ⊃‴࢚ࢿࣝࢠ࣮◊✲ࢭࣥࢱ࣮ࡢࢱࣥࢹ࣒ຍ㏿ჾࡢࣅ࣮࣒ࣛ࢖࡛ࣥ 0H9+Hࣅ࣮࣒ࢆ⏝࠸࡚ࠊᩓ஘ゅ rࡲࡓࡣ r࡛ ᐃࡋࡓࠋ[ 6LFP

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)LJ  5%6& VSHFWUD LQGLFDWLQJ WKH UHGXFWLRQ RI
GDPDJHSHDNVDIWHUWKHUPDODQQHDOLQJDQGQHXWURQLUUDGLDWLRQ DWWKHUHDFWRUFRUHWHPSHUDWXUHࣕࣝ⤖ᬗᡂ㛗ࡀ㉳ࡁࡓ࡜࠸࠺ࡼࡾࡶࠊ㠀ᬗ㉁ᒙࡢ୧
➃࡟ṧ␃ࡋࡓ㠀ᬗ㉁໬ࡋ࡚࠸࡞࠸㔜ᦆയᒙࡀ⤖ᬗᛶᅇ᚟ࡋࡓࡶࡢ࡜⪃࠼ࡽࢀࡿࠋ )LJ ࡢ 5%6& ࢫ࣌ࢡࢺࣝࡣ  FP ࡛ᦆയᑟධࡋࡓヨᩱ࡟ᑐࡍࡿ㛗ᮇ↷ᑕタഛࢆ⏝࠸ࡓ⅔ᚰ ᗘ࡛ࡢ୰ᛶᏊ↷ᑕࡢ⤖ᯝࢆ♧ࡋ࡚࠸ࡿࠋᮍ↷ᑕヨᩱ㸦ᐇ⥺㸧ࠊ⇕ฎ⌮ࡢࡳࡢヨᩱ㸦୸㸧ࠊ୰ᛶᏊ↷ᑕࡋࡓヨᩱ㸦ሬࡾࡘࡪࡋࡓ୸㸧ࠊࣛࣥࢲ࣒ࢫ࣌ࢡࢺࣝ㸦⣽࠸ᐇ⥺㸧ࠊ༢⤖ᬗࡢࢫ࣌ࢡࢺࣝ㸦Ⅼ⥺㸧ࡀࣉࣟࢵࢺࡉࢀ࡚࠸ࡿࠋ↷ᑕ ᗘࡣ Υ௨ୗ࡛࠶ࡿࡀࠊࡇࡢ ᗘᇦ࡛ࡣࠊࢩ
ࣜࢥࣥࡢ㔜ᦆയᒙࡢᅇ᚟㔞ࡣᑠࡉࡃࠊ ᗘ౫Ꮡᛶࡣ
↓ど࡛ࡁࡿ⛬ᗘ࡛࠶ࡿࠋ⇕ฎ⌮ࡢࡳࡢヨᩱࡢฎ⌮ᗘࡣ Υ࡜ࡋࡓࠋࡲࡓࠊ㛗ᮇ↷ᑕ࡟ࡼࡿ୰ᛶᏊ↷ᑕ
࡛ࡣࠊ.85 ࡢ㐠㌿ࣃࢱ࣮ࣥ࡜ࡋ࡚ࠊẖ㐌⅔ᚰ ᗘࡀᐊ ࠿ࡽ↷ᑕ ᗘࡲ࡛ቑຍ࡜ῶᑡࢆ⧞ࡾ㏉ࡍࡀࠊࡑࢀ࡜ྠ➼ࡢࣃࢱ࣮࡛ࣥ⇕ฎ⌮ࢆࡋࡓࠋ5%6& ࢫ࣌ࢡࢺࣝࢆぢࡿ࡜ࠊΥࡢሙྜ࡜␗࡞ࡾࠊ⤖ᬗᛶᅇ᚟ࡢ
ᗘྜ࠸ࡣ኱ࡁࡃ࡞ࡃࠊᮍฎ⌮ࡢヨᩱࡢᦆയࣆ࣮ࢡ࡟
㏆࠸㧗ࡉࡢࣆ࣮ࢡࡀṧࡗ࡚࠸ࡿࠋࡑࡢ୍᪉࡛ࠊ⇕ฎ⌮ࡢࡳࡢヨᩱ࡟ẚ࡭࡚ࠊ୰ᛶᏊ↷ᑕࡋࡓヨᩱࡢ᪉ࡀప࠸ᦆയࣆ࣮ࢡࡀᚓࡽࢀ࡚࠾ࡾࠊ୰ᛶᏊ↷ᑕ࡟ࡼࡿ⤖ᬗᛶᅇ᚟ຠᯝࡀ࠶ࡗࡓࡇ࡜ࡀศ࠿ࡿࠋ
ࡇࡢࡼ࠺࡟ࠊ.85 ࢆ⏝࠸ࡓ୰ᛶᏊ↷ᑕ࡟ࡼࡾࠊ࢖
࢜ࣥࣅ࣮࣒࢔ࢽ࣮ࣜࣥࢢ࡜ྠᵝࡢ↷ᑕࢆ⏝࠸ࡓ⤖ᬗᛶᅇ᚟ࡀ୰ᛶᏊ↷ᑕ࡛ࡶ㉳ࡁࡿࡇ࡜ࡀึࡵ࡚♧ࡉࢀࡓࠋ ↷ᑕ࡟ࡼࡿ⤖ᬗᛶᅇ᚟ࡣᙎࡁฟࡋᦆയ࡟ࡼࡾⅬḞ㝗ࡢᙧᡂࢆඖ࡟㐍ࡴ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡀࠊᙎࡁฟࡋ
ᦆയ㔞㸦࠶ࡿ࠸ࡣᙎᛶ⾪✺࢚ࢿࣝࢠ࣮ࡢ௜୚㔞㸧࡟ᑐࡍࡿ⤖ᬗᡂ㛗㔞ࢆ࢖࢜ࣥࣅ࣮࣒࢔ࢽ࣮ࣜࣥࢢࡢሙ
ྜ࡜ẚ㍑᳨ウࡋࡓࠋ࢖࢜ࣥࣅ࣮࣒࢔ࢽ࣮ࣜࣥࢢࡢ⤖ᬗᡂ㛗㔞ࡢࢹ࣮ࢱࡣ㐣ཤ࡟௚ࡢࢢ࣮ࣝࣉ࠿ࡽⓎ⾲ࡉࢀࡓㄽᩥ࠿ࡽᚓࡓࠋࡑࢀࡒࢀࡢᐇ㦂ࡢ⤖ᬗᡂ㛗㔞ࡣ↷ᑕ᮲௳࠿ࡽᙎࡁฟࡋᦆയ㔞࡛ṇつ໬ࡋࡓࠋࡇࡢࡼ
࠺࡟ࡋ࡚ࠊኚ᥮ࡋࡓࢹ࣮ࢱࢆ࢔ࣞࢽ࢘ࢫࣉࣟࢵࢺࡋ
࡚ࡳࡿ࡜ࠊ୰ᛶᏊ↷ᑕࡢࢹ࣮ࢱ࡜࢖࢜ࣥ↷ᑕࡢࢹ࣮ࢱࡣ࡯ࡰྠࡌഴྥࢆ♧ࡍࡇ࡜ࡀ♧ࡉࢀࡓ>@ࠋ࢝ࢫࢣ࣮ࢻᦆയࡢศᕸࡣ኱ࡁࡃ␗࡞ࡿࡶࡢࡢࠊ࢖
࢜ࣥ࡜୰ᛶᏊࡣ⤖ᬗᛶᅇ᚟࡟㛵ࡋ࡚ࡣྠ➼ࡢᐤ୚ࢆᮦᩱ࡟୚࠼ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋࡇࡢࡇ࡜ࡣࠊ㟁Ꮚࣅ࣮࣒࡟ࡼࡿ⤖ᬗᛶᅇ᚟ࡢ≉␗ᛶࢆ㝿❧ࡓࡏࡿࡇ࡜࡟
࡞ࡾࠊ㟁Ꮚࣅ࣮࣒࡜࢖࢜ࣥࡸ୰ᛶᏊ↷ᑕ࡜ࡢ㛫࡟࠶ࡿᕪࡣࠊᙎࡁฟࡋᦆയ㔞࡟ᑐࡍࡿ㟁Ꮚບ㉳ࡢ㔞㸦࠶ࡿ࠸ࡣ㠀ᙎᛶ⾪✺࢚ࢿࣝࢠ࣮ࡢ௜୚㔞㸧ࡀ┦ᑐⓗ࡟኱ࡁ࠸ࡇ࡜ࡀཎᅉ࡛ࡣ࡞࠸࠿࡜ண᝿ࡉࢀࡿࠋࡕ࡞ࡳ
࡟ࠊୖグࡢ࢖࢜ࣥ࠾ࡼࡧ୰ᛶᏊ↷ᑕ࡟ࡼࡿ⤖ᬗᛶᅇ᚟ࡢሙྜ࡛ࡶࠊ㟁Ꮚບ㉳ࡣࡶࡕࢁࢇ㉳ࡁࡿࡀࠊᐇ㦂ࡋࡓ⠊ᅖ࡛ࡣࠊ㟁Ꮚບ㉳ࡢᙳ㡪ࡣ኱ࡁࡃ࡞࠸࡜ุ᩿
ࡉࢀࡓࠋ㸲㸬௒ᚋࡢᒎ㛤㸸୰ᛶᏊ↷ᑕ࡟ࡼࡿ⤖ᬗᛶᅇ᚟ࡢᐇ
㦂࡟㛵ࡋ࡚ࡣࠊ.85 ࡟ࡼࡿࡇࢀ௨ୖࡢᐇ㦂ࡢᐇ᪋ࡣ㞴ࡋ࠸࡜⪃࠼࡚࠸ࡿࡀࠊ㟁Ꮚ㢧ᚤ㙾࡛↷ᑕࢆཷࡅࡓ
ᒙࡢᚤ⣽ᵓ㐀ࢆㄪ࡭࡚࢖࢜ࣥ↷ᑕ࡜ẚ㍑᳨ウࡍࢀࡤ᪂ࡓ࡞▱ぢࡀᚓࡽࢀࡿྍ⬟ᛶࡀ࠶ࡿࠋ ࡲࡓࠊࡇࢀࡲ࡛ࢩࣜࢥࣥ࡞࡝ࡢ༙ᑟయヨᩱࢆᑐ㇟࡜ࡋ࡚ࡁࡓࡀࠊ㔠ᒓᮦᩱ࡛ࡢ↷ᑕㄏ㉳⤖ᬗᛶᅇ᚟ࢆ
᫂☜࡟♧ࡋࡓ◊✲ሗ࿌ࡣ࡞࠸ࡶࡢࡢࠊ༙ᑟయࡢሙྜ
࡜ྠ➼ࡢຠᯝࡀぢࡽࢀࡿྍ⬟ᛶࢆ♧၀ࡍࡿㄽᩥࡸண

ഛᐇ㦂ࡢ⤖ᯝࡀ࠶ࡾࠊ㔠ᒓᮦᩱ࡬ࡢᒎ㛤ࡶ᳨ウࡋࡓ࠸ࠋ ホ౯ᡭἲ࡜ࡋ࡚ࡣࠊ⌧ᅾᩚഛࢆ㐍ࡵ࡚࠸ࡿప㏿㝧㟁Ꮚࣅ࣮࣒ࣛ࢖ࣥࡢ฼⏝ࡶ᳨ウࡋ࡚࠸ࡿࠋ㝧㟁Ꮚᾘ⁛ศගἲ࡟ࡼࡾࠊ࢖࢜ࣥᩓ஘࡛ࡣศ࠿ࡽ࡞࠸᪂ࡓ࡞
▱ぢࢆᚓࡿࡇ࡜ࡀᮇᚅࡉࢀࡿࠋ ࡉࡽ࡟ࠊ㠀ᬗ㉁໬ࡋ࡚࠸࡞࠸㔜ᦆയᒙࡢ↷ᑕㄏ㉳⤖ᬗᛶᅇ᚟ࡢࣔࢹࣜࣥࢢ࡟ࡣࠊ཯ᛂ㏿ᗘㄽࢆ⏝࠸ࡓ࢔ࣉ࣮ࣟࢳࡀྍ⬟࡛࠶ࡿ࡜⪃࠼ࡽࢀࠊࡇࡢ᪉ྥࡢ◊✲ࡶ㐍ࡵࡓ࠸ࠋ
㸳㸬ࡲ࡜ࡵ㸸࢖࢜ࣥࣅ࣮࣒↷ᑕ࡟ࡼࡾㄏ㉳ࡉࢀࡿ⤖ᬗᛶᅇ᚟⌧㇟ࢆࡇࢀࡲ࡛◊✲ࡋࠊࡑࡢᘏ㛗࡜ࡋ࡚ࠊ.85 ࢆ౑ࡗࡓ୰ᛶᏊ↷ᑕ࡟ࡼࡾㄏ㉳ࡉࢀࡿ⤖ᬗᛶᅇ᚟ࡢほ ࡟ࡶᡂຌࡋࡓࠋ࢖࢜ࣥࣅ࣮࣒ࢆྵࡵࡓ㧗࢚ࢿࣝࢠ࣮⢏Ꮚ࡟ࡼࡿ↷ᑕㄏ㉳ࡢ⤖ᬗᛶᅇ᚟ࡢ◊✲ࢆ⥲ྜⓗ࡟㐍ࡵࠊ཯ᛂᶵᵓࡢ⌮ゎ࡜ࣔࢹࣜࣥࢢࢆ⾜࠺ࡇ࡜࡟ᣮᡓࡋ࡚࠸ࡁࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ
ㅰ㎡㸸ᮏ◊✲ࢆ㐙⾜ࡍࡿ࡟࠶ࡓࡾࡈ༠ຊࢆ㡬࠸ࡓ௨ୗࡢ᪉ࠎ࡟ឤㅰࡋࡲࡍ㸦ᣓᘼෆࡣ◊✲ᐇ᪋᫬ࡢᡤ
ᒓ㸧㸸⩏ᐙᩄṇࠊᚎ⹹ࠊబ⸨⣫୍ࠊᯘ⚞ᙪࠊ୰㔝ᖾᘅ㸦ி㒔኱Ꮫ㸧
ࠊ-6:LOOLDPV㸦$XVWUDOLDQ1DWLRQDO
8QLYHUVLW\㸧ࠊ⸨஭වᰤࠊᇼ㔝⿱἞ࠊⲔ㇂ཎ᫛⩏ࠊ᮳㔝⏤᫂ࠊᆤෆಙ㍤ࠊ㕥ᮌⰋ୍㸦⏘ᴗᢏ⾡⥲ྜ◊✲ᡤ㸧ࠊఀ⸨៞ᩥࠊᏳ⏣ၨ௓ࠊ▼⚄㱟ဢ㸦ⱝ⊃‴࢚ࢿࣝࢠ࣮◊✲ࢭࣥࢱ࣮㸧ࠋཧ⪃ᩥ⊩>@ 5* (OOLPDQ HW DO 1XFO ,QVWUXP  0HWKRGV 3K\V
5HV%  
>@ $ .LQRPXUD HW DO 3K\V 5HY %  
>@ $ .LQRPXUD HW DO $SSO 3K\V /HWW   – 
>@ $.LQRPXUDHWDO1XFO,QVWUXP0HWKRGV3K\V5HV%  

0HDVXUHPHQWVRILUUDGLDWLRQLQGXFHGFU\VWDOOLQHUHFRYHU\DQGLWVPRGHOOLQJ$WVXVKL.LQRPXUDDNLQRPXUD#UULN\RWRXDFMS㻙㻌㻡㻟㻌㻙

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M@F$Ƅ1ræÀòt4ıĹŀ-ĀŴ%ŕƊēĹŀ%¦$ Ňz1[1,2]
ƗƔťöś.'Ɗđ~ÏĪæƛb<T<g6i8jAƑMAƒĕ$.Ĳ#1 7Li ĢÛ4,
(7Li2S)x(P2S5)100-x =eFƑx = 50Ɠ60Ɠ70ƒ4ś 7Li &fL9a%¥0ťö$.1
ræÀ%¨¡4ë1+$ı 1*㻙 㻡㻠㻌㻙

ħĭ1!
(7Li2S)70(P2S5)30 =eF4ņ 240ºC
7
Li7P3S11 ğÅÆŉÿ4ś2/%ťö$Íwę8jYlKjFĞÆ4ŗ Ɗđ~ÏÛ.'Ęæ:Ug?l4Ē+°Ɩ$(7Li2S)x(P2S5)100-x =eFƑx = 50Ɠ60Ɠ70ƒ.'7
Li7P3S11 =eFHe`M@F%Èĝ %Ɗđ~ÏÛRT 4ļ=eFƍµ$ x %º$RT åġ$nû(7Li2S)70(P2S5)30 =eF & 10–4
S/cm * Ż/$7Li7P3S11 =eFHe`M@F%RT &(7Li2S)70(P2S5)30 =eF.0,ƖćƐ
10–3 S/cm 4ļFig. 1. Electrical conductivities of (7Li2S)x(P2S5)100-x
glasses (x = 50, 60, and 70) () and 7Li7P3S11 metastable
crystal () at room temperature.
ƘƔČŹ!fL9a8;j~ÏňŰƛXgFræÀ
®ìÇƏ&½ßÛƆÀŸ­ùŤƕĩŬkįªľÄÇƏùŤƑJ–PARC/MLFƒ$ŤŌ2 1ƐßÛòtřŌ NOVAƑBL21ƒ4ı ŗ[3]*ñÎ X ŋ®ìÇƏ&½´ñÎùŤƑSPring–8ƒ$ŤŌ2 1ƋÿŬĩŬıvŲ®
ìšƑBL04B2ƒ4ı ŗ[4]RMC cPfj
A4ŗ+®ìPlJ I(Q)$Í¨¡Śď¼ſòtŚďƋ×ěæòtŚďń4ŗ ČŹ¯
À S(Q)4Ē+*7Li7P3S11 ğÅÆŉÿ$
&Þ(1).0vÓƄó g(r)4Ē+g ( r ) = 1+1
Q S (Q ) 1sin (Qr ) dQ (1)22 r  0 Q &òt]@Qg%½r &Àƃůƈ0 &ÀóËÛ
1(7Li2S)x(P2S5)100-x =eFƑx =50Ɠ60Ɠ70ƒ$ & S(Q)PlJ47Li7P3S11 ğÅÆŉÿ$ & g(r)PlJ4ı  RMC cP
fjA4ŗ RMC HgƑłøƒ%m
ų%C8G&ņ 46 ÅÀ%Ŋó&ņ 5000
1Fig. 2 $ RMC cPfjA%ŉĆ$ ļ
2/%ŠąŉĆ/(7Li2S)x(P2S5)100-x =eFƑx =50Ɠ60Ɠ70ƒ.' 7Li7P3S11 ğÅÆŉÿ%ƘĎČ
Ź4ã1! ƑFig. 3ƒ 

Fig. 4. Predicted conduction pathways of Li ions in(7Li2S)x(P2S5)100-x glasses (x = 50, 60, and 70) and7
Li7P3S11 metastable crystal.

Fig. 2. S(Q) data of (7Li2S)x(P2S5)100-x glasses (x = 50, 60,
and 70) and g(r) data of 7Li7P3S11 metastable crystal obtained from neutron diffraction and synchrotron X-ray
diffraction experiments, together with S(Q) and g(r) dataobtained from the RMC modeling.
Fig. 3. Three-dimensional structures of (7Li2S)x(P2S5)100-x
glasses (x = 50, 60, and 70) and 7Li7P3S11 metastable
crystal obtained from the RMC modeling.
㻙 㻡㻡㻌㻙

Fig. 5. Lithium stable (light gray) and metastable (darkgray) regions in conduction pathways of Li ions (enlarged for clarity).
 Ď$BVS Šą$.0(7Li2S)x(P2S5)100-x =eFƑx
= 50Ɠ60Ɠ70ƒ.' 7Li7P3S11 ğÅÆŉÿ%fL9
a8;j~ÏňŰ%£Ş4ŗƑFig. 4ƒã/2fL9a8;j~ÏňŰ&Li 8;jÅÆ$Â² 1 ÅÆƍµ !--pÅÆ#ƍµƑ_OjDdg:Ug?l--Ɛ ƍµƒ
1 ğÅÆƍµ 422§5 0qŏ
41!&Êý1Fig. 5 $fL9a
8;j~ÏňŰ %í½°4ļ°r$ ƓÅÆƍµ4Ŗ ĤŔğÅÆƍµ4Ģ ĤŔ  1°/31.$(7Li2S)50(P2S5)50=eF &ğÅÆƍµ½4+ 1x%º$ğÅÆƍµĜÑ|30$ÅÆƍµº 1/$ğÅÆŉÿ$.ÅÆƍµ½4+1.$#1%.$Li2S ĢÛ%º!ğÅÆŉÿ$.
Li 8;jĿ- Į¹±r$áè2
 1!31

4ilhjNƄó L(,)$.ţŵS(Q,)F^@Qg$Í1Z7MO7jA/ã/2ilhjNƄó%Ö 4ı Jump diffusion
cPg$â Li 8;j%Ø³Edj\ůƈ<l>4
Ē+%ŉĆLi 8;jØ³ 4.3 Å fL9a
8;j~ÏňŰ4Edj\#/Ŀ
1!4ü/$ƚƔĀŴ%ŕƊēĹŀ%¦ƛ÷:Ug?lkİĊêŘŊ¤ƂĳčČƑNEDOƒƌ÷´ŕƊēŃľÄ¶ĻĹŀuĊƑRISING uĊƛØè  ÙÛ Øè 
ÙÛƒ%mĮ!ŕƊē%ÇĮ¹o$.1
ĞÆƑ;^ejRĞÆƒ4sĶĴ!ræÀ®ìřŌ ĪĐĮ¹ræÀ®ìřŌƑSPICAƒ 
J–PARC/MLF $ÝŤ2[6]Fig. 8 $ SPICA Ă
4ļ*ræÀ%Ɛ Ŷźő4ı
SPICA 4ı ÇƊē%;^ejRĞÆ$.
ďċkŪċ%ČŹ»4f6gJ8a şÌ 1.$# 1[7]


Fig. 6. S(Q,) spectra (Q = 0.32 Å-1) for 7Li7P3S11 metastable crystal collected at 150, 297, and 473 K.

Fig. 7. HWHM  of the Lorentzian component L(, )with respect to Q2 at 473 K. The dashed blue line represents the least-squares fit obtained with the jump diffusion model.

ƙƔfL9a8;j%K8S`@FşĞƛ/$
Li 8;j%4ķîşĞ1+K8S`@
FŠąřŌ DNAƑBL02ƒ4ı[5]ĝÛ4»
#/ræÀğàæòtÇƏ4ŗ Fig. 6$ļ.$473 K $  Li 8;j%mŽ±r ¿+!4ļğàæòtè4şĞ1!$è/$ ğàæòtè

Fig. 8. Special environment neutron powder diffractometer, SPICA, installed at the BL09 beam port in
J–PARC/MLF [6].
Ŏõī[1] K. Mori et al., Chem. Phys. Lett., 584 (2013)
113-118.
[2] K. Mori et al., Phys. Rev. Applied, 4 (2015) 054008(pp. 1–6).
[3] ½ Ã « , Ɓ ũ ū ¾ ż , ú Ă ŉ ÿ Ä } ŧ , 50(2008) 2934.
[4] S. Kohara et al., Nucl. Instrum. Methods Phys. Res. A,
467468 (2001) 10301033.
[5] K. Shibata et al., JPS Conf. Proc., 8 (2015) 036022(pp. 1–7).
[6] M. Yonemura, K. Mori et al., J. Phys.: Conf. Ser., 502(2014) 012053 (pp. 1–4).
[7] S. Taminato et al., Scientific Reports, 6 (2016) 28843(pp. 1–12).

The front line of the lithium-ion battery study using neutron scatteringKazuhiro Mori
kmori@rri.kyoto-u.ac.jp
㻙 㻡㻢㻌㻙

ከඖ⣲࣓ࢫࣂ࢘࢔࣮ศගἲࡢจ⦰⣔◊✲࡬ࡢ㧗ᗘᛂ⏝㻔㻼㻶㻟㻕㸦ி኱ཎᏊ⅔ࠊ៞ᛂ኱⌮ᕤ 1ࠊᖇி኱⌮ᕤ 2ࠊ኱㜰ᕷ኱⌮ 3ࠊᮾ኱⥲ྜᩥ໬㸦⌧ࢺࣚࢱ⌮◊㸧4ࠊ஑኱⌮ 5ࠊྠ኱⌮ᕤ 6ࠊ኱㜰ᗓ኱ 21ୡ⣖ 7ࠊி኱ᕤ 8ࠊᮾ㑥኱⌮ 9ࠊឡ፾኱⌮ᕤ 10ࠊ⟃Ἴ኱ᩘ⌮≀㉁ 11ࠊ༓ⴥ኱⌮ 12㸧‫℩ۑ‬ᡞ ㄔࠊ໭ᑿ┿ྖࠊᑠᯘᗣᾈࠊ㰻⸨┿ჾྡࠊ❑⏣༟ぢࠊቑ⏣ ுࠊ㯮ⴱ┿⾜ࠊ⚄ཎ㝧୍ 1ࠊ୰ᮧ┿୍ 2ࠊ⠛⏣ᆂྖ 3 ࠊᑠᓥ᠇㐨 4 ࠊᶓᒣᣅྐ 5 ࠊᑠᑎᨻே 6 ࠊᒣ⏣ᗄஓ 7 ࠊ⸨⏣᫭ྖ 8 ࠊ㧗ᶫṇ 9 ࠊᯇୗṇྐ 10 ࠊᒣᮏὈᙪ 11ࠊᶓ⏣⣫Ꮚ 12㸯㸬ࡣࡌࡵ࡟
࣓ࢫࣂ࢘࢔࣮ศගἲࡣࠊཎᏊ᰾ࢆࣉ࣮ࣟࣈ࡜ࡋ࡚
ࡑࡢࣉ࣮ࣟࣈཎᏊ᰾࿘㎶ࡢ㟁Ꮚ≧ែࢆࠊཎᏊ᰾࡜㟁Ꮚ⣔࡜ࡢ┦஫స⏝࡟ࡼࡿ͆ཎᏊ᰾ࡢ࢚ࢿࣝࢠ࣮‽఩࡬ࡢᙳ㡪͇࡜ࡋ࡚ ᐃࡍࡿࡶࡢ࡛࠶ࡿࠋࡑࡢࡓࡵࠊ
≀㉁ෆࡢ≉ᐃඖ⣲࡟ࡘ࠸࡚ࡢᛶ㉁ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ
࡜ࡀ࡛ࡁࡿ㠀ᖖ࡟᭷ຠ࡞ ᐃἲ࡛࠶ࡿࠋࣉ࣮ࣟࣈ࡜
ࡋ࡚ࡣ㏻ᖖࡢሙྜࠊᏳᐃྠ఩యࢆ⏝࠸ࡿࡇ࡜࠿ࡽࠊ
ඖ⣲ࡢቯኚ࡞࡝ࡀ⏕ࡌࡓࡾ࢖࢜ࣥࡢᡴࡕ㎸ࡳ࡞࡝࡟ࡼࡿヨᩱࡢᦆയ࡞࡝ࡀ࡞࠸ࠋࡼࡗ࡚ࠊ≀ᛶ࡟ᙳ㡪ࢆ୚࠼ࡿࡇ࡜࡞ࡃ㠀ᖖ࡟ከࡃࡢヨᩱ࡛ࡢ ᐃࡀྍ⬟࡛
࠶ࡾࠊ57Fe ࢆ୰ᚰ࡜ࡋࡓከࡃࡢ◊✲ࡀ࡞ࡉࢀ࡚࠸ࡿࠋ
࣓ࢫࣂ࢘࢔࣮ศගἲ࡛ࡣࠊᏳᐃྠ఩యࢆྵࡴ ᐃヨᩱ࡟ᑐࡋ࡚ࠊእ㒊ࡢᨺᑕᛶྠ఩య㸦RI㸧⥺※࠿ࡽγ ⥺ࢆ↷ᑕࡋࠊࡑࡢȚ⥺ࡢ྾཰࢚ࢿࣝࢠ࣮౫Ꮡᛶࢆ
ᐃࡍࡿࡇ࡜࡟ࡼࡗ࡚࣓ࢫࣂ࢘࢔࣮ࢫ࣌ࢡࢺࣝࢆᚓࡿ
ࡀࠊ㛗ᑑ࿨࡞ RI ⥺※ࡀධᡭྍ⬟࡞ 57Fe ࡞࡝ࡢඖ⣲௨እࡢሙྜ࡟ࡣࠊཎᏊ⅔ࡸຍ㏿ჾ࡞࡝࡛▷ᑑ࿨ RI ⥺※ࢆస〇ࡍࡿࡇ࡜࡟ࡼࡗ࡚ࠊ ᐃࡀྍ⬟࡜࡞ࡿࠋࡇࡢࡼ࠺࡞ ᐃᑐ㇟࡜࡞ࡿ࣓ࢫࣂ࢘࢔࣮᰾✀ࢆቑࡸࡍࡇ
࡜࡟ࡼࡗ࡚ࠊ⌧௦ࡢ≀㉁࣭⏕࿨⛉Ꮫ◊✲࡛ᚲせ࡜ࡉࢀࡿከࡃࡢඖ⣲࡛ࡢ ᐃࡀྍ⬟࡜࡞ࡿࠋࡑࡇ࡛ࠊከඖ⣲࡟ࡼࡿ࣓ࢫࣂ࢘࢔࣮ศගἲࡢ☜❧ࢆ┠ⓗࡢ୍ࡘ࡜ࡋ࡚ࣉࣟࢪ࢙ࢡࢺࢆᵓ⠏ࡋࡓࡶࡢ࡛
࠶ࡿࠋࡲࡓࠊ㏆ᖺᑟධࡋࡓᙉ☢ሙୗ࣓ࢫࣂ࢘࢔࣮ศ
ග⿦⨨ࡣࠊ☢ᛶ➼ࡢ◊✲࡟࠾࠸࡚㠀ᖖ࡟ᙉຊ࡞ࢶ࣮
࡛ࣝ࠶ࡿࠋࡇࢀࡽࡢᵝࠎ࡞ศ㔝࡛ࡢ᭷ຠά⏝ࢆᅗࡿࡓࡵ࡟ࡣࣉࣟࢪ࢙ࢡࢺ࡜ࡋ࡚◊✲ࢆ❧ࡕୖࡆ࡚᥎㐍ࡋ࡚࠸ࡃᚲせࡀ࠶ࡿࠋᮏࣉࣟࢪ࢙ࢡࢺ◊✲ࡣࠊከඖ⣲ ᐃࡸᙉ☢ሙୗ ᐃ࡞࡝ࡢᙉຊ࡞ศගἲࢆ⏝࠸ࡿࡇ࡜࡛ࠊ࣓ࢫࣂ࢘࢔࣮ศගἲࡢ㧗ᗘ࡞ᛂ⏝◊✲࡜᪂ࡋ࠸᪉ἲㄽࡢᵓ⠏ࢆከᵝ࡞◊✲ศ㔝࡟࠾࠸࡚☜❧ࡍࡿࡇ࡜ࢆ┠ᣦࡋࡓࡶࡢ࡛࠶ࡿࠋ

ࣉࣟࢪ࢙ࢡࢺෆࡢྛ◊✲ࡢࢸ࣮࣐࡜ศᢸ௦⾲⪅ࡣ௨ୗࡢ࡜࠾ࡾ࡛࠶ࡿࠋ
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㸦Aun(SeR)m, etc.㸧ࡢᵓ㐀࠾ࡼࡧ㟁Ꮚ≧ែࡢゎ᫂㸦ᑠᓥ᠇㐨㸧(2014)㻙 㻡㻣㻌㻙

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࣌ࢡࢺࣝ ᐃ㸦⠛⏣ᆂྖ㸧(2014)○࣓ࢫࣂ࢘࢔࣮ศගἲࢆ⏝࠸ࡓ␗ᖖ㧗ཎᏊ౯ Fe ࣌ࣟࣈࢫ࢝࢖ࢺ㓟໬≀ࡢ㟁Ꮚ≧ែゎ᫂㸦ᒣ⏣ᗄஓ㸧(2014)○࣓ࢫࣂ࢘࢔࣮ศගἲ࡟ࡼࡿ᪂つᴟᛶ㓟໬≀☢ᛶయࡢᒁᡤᵓ㐀࡜☢Ẽᵓ㐀ࡢホ౯㸦⸨⏣᫭ྖ㸧(2014)○㍤▼༢⤖ᬗࡢᐃ᪉఩ヨᩱࡢ࣓ࢫࣂ࢘࢔࣮ࢫ࣌ࢡࢺࣝ ᐃ㸦⠛⏣ᆂྖ㸧(2015)○࣐ࣝࢳࣇ࢙ࣟ࢖ࢵࢡ Fe 㓟໬≀ࡢ☢ሙ୰࣓ࢫࣂ࢘࢔
࣮ศග㸦୰ᮧ┿୍㸧(2015㹼2016)○197Au ࣓ࢫࣂ࢘࢔࣮ศගἲ࡟ࡼࡿ㉸ཎᏊ౯࢔ࣥࢳࣔ
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㸦2015㹼2016㸧○ΰྜ࢔ࢽ࢜ࣥᒙ≧☢ᛶయࡢࢫࣆࣥᐦᗘἼ࡟㛵ࡍࡿ◊✲㸦⚄ཎ㝧୍㸧(2016)○༙ᑟయ᳨ฟჾࢆ⏝࠸ࡓ㢧ᚤ࣓ࢫࣂ࢘࢔࣮ศගἲࡢ
᭷ຠᛶཬࡧᡭἲࡢ᳨ウ(⠛⏣ᆂྖ) (2016)○࣑࢜ࢢࣟࣅࣥࡢ࣒࣊㕲ࡢ㟁Ꮚ≧ែ࡜㓟⣲ぶ࿴ᛶ࡜ࡢ┦㛵ࡢゎ᫂㸦ᒣᮏὈᙪ㸧(2016)○ᕼᅵ㢮 Er ඖ⣲࣓ࢫࣂ࢘࢔࣮ศගᡭἲࡢ☜❧(ᶓ⏣⣫Ꮚ) (2016)○67Zn ࣓ࢫࣂ࢘࢔࣮ศගࡢ㛤Ⓨ㸦㰻⸨┿ჾྡ㸧(2016)ᮏࣉࣟࢪ࢙ࢡࢺࡣࠊ2014 ᖺᗘ࠿ࡽ 2016 ᖺᗘࡲ࡛࡛࠶ࡿࡀࠊ2014 ᖺᗘࡢึࡵ࡟ KUR ࡢ㐠㌿ࡀ೵ṆࡋࡓࡓࡵࠊKUR 㐠㌿ࡀᚲ㡲࡜࡞ࡗ࡚࠸ࡿ࠸ࡃࡘ࠿ࡢ◊✲ㄢ㢟࡟ࡘ࠸࡚ࡣᐇ᪋ࡍࡿࡇ࡜ࡀ࡛ࡁ࡞࠿ࡗࡓࠋ࡞
࠾ࠊ2016 ᖺᗘࡣㄢ㢟ࡀ⌧ᅾ㐍⾜୰࡛࠶ࡾࠊ2016 ᖺᗘ
ᮎ࡟ࡣ KUR 㐠㌿෌㛤ࡀぢ㎸ࡲࢀ࡚࠸ࡿࡓࡵࠊࡉࡽ࡞
ࡿ◊✲ᡂᯝࡶண᝿ࡉࢀࡿࡀࠊḟ⠇௨㝆࡟ࡇࢀࡲ࡛ᚓ
ࡽࢀࡓ୺࡞◊✲ᡂᯝࢆ⤂௓ࡍࡿࠋ㸰㸬୺࡞◊✲ᡂᯝ 㕲⣔㉸ఏᑟయ %Dx.x)H$V ࡢ )H ࣓ࢫࣂ࢘࢔࣮ຠ
ᯝ࡟ࡼࡿ◊✲
㸦ி኱⅔ ໭ᑿ┿ྖ㸧㕲⣔㉸ఏᑟయࡣࠊࡑࡢẚ㍑ⓗ㧗࠸㉸ఏᑟ㌿⛣ ᗘ࡜ࠊࡇࢀࡲ࡛☢ᛶඖ⣲࡛࠶ࡿࡓࡵ㉸ఏᑟ࡟ࡣ࡞ࡽ࡞
࠸࡜⪃࠼ࡽࢀ࡚࠸ࡓ㕲ࡀ㉸ఏᑟࢆᢸ࠺᪂つ࡞㉸ఏᑟయ࡜ࡋ࡚ὀ┠ࢆ㞟ࡵ࡚࠾ࡾࠊࡑࡢ㉸ఏᑟⓎ⌧ᶵᵓࡢゎ᫂࡟ྥࡅࡓ◊✲ࡀᛴ㏿࡟㐍ᒎࡋ࡚࠸ࡿࠋ)H ࣓ࢫࣂ࢘࢔࣮ศගἲࡣ㕲ࡢࡳࡢ㟁Ꮚ≧ែࡸ☢ᛶࡢ᝟ሗࢆ
ᢳฟ࡛ࡁࠊࡲࡓᙉ☢ሙୗࡢ ᐃ࡟ࡼࡾࠊࡇࡢ㉸ఏᑟ
యࡢⓎ⌧ᶵᵓゎ᫂ࡢ㘽࡜࡞ࡿ☢ᛶ࡟ࡘ࠸࡚ࡢ᝟ሗࡀ
ᚓࡽࢀࡿ࡜ᮇᚅࡉࢀ࡚࠸ࡿࠋ%D)H$V ࡣࡇࡢ㉸ఏᑟయࡢẕ≀㉁࡛࠶ࡾࠊ㉸ఏᑟ

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䣖䣴䣣䣰䣵䣯䣫䣵䣵䣫䣱䣰

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䣄䣣䣈䣧䢴䣃䣵䢴
䢯䢵

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䣘䣧䣮䣱䣥䣫䣶䣻䢢䢪䣯䣯䢱䣵䢫䣘䣧䣮䣱䣥䣫䣶䣻䢢䢪䣯䣯䢱䣵䢫)LJ7\SLFDO0|VVEDXHUVSHFWUDRI %D)H$Vࢆ♧ࡉ࡞࠸ࡀ⣙  . ࡛཯ᙉ☢ᛶࢆ♧ࡍࠋ୍᪉ࠊ.
ࢆࢻ࣮ࣉࡍࡿࡇ࡜࡟ࡼࡾ㉸ఏᑟయ࡜࡞ࡾࠊx  ࡛ࡣ⣙  . ࡛㉸ఏᑟ㌿⛣ࢆ♧ࡍࠋࡲࡓ x  ࡛ࡣ㉸ఏᑟ࡜☢Ẽ⛛ᗎࡀඹᏑࡍࡿ㡿ᇦࡀᏑᅾࡍࡿࡇ࡜ࡀ♧䢳䢰䢲䢲၀ࡉࢀ࡚࠸ࡿࠋᮏ◊✲࡛ࡣࠊࡇࢀࡽࡢ )H ࣓ࢫࣂ࢘࢔࣮ศගࢆᐇ᪋ࡋࠊ㉸ఏᑟ┦ࡸ☢Ẽ⛛ᗎ┦ࡢ㟁Ꮚ≧ែࡸ☢ᛶ࡟ࡘ࠸࡚᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚◊✲ࢆ⾜ࡗࡓࠋ%D)H$V ࡛ࡣ )LJ ࡢࡼ࠺࡟⣙  . ࡼࡾప ࡟࠾࠸࡚☢Ẽศ⿣ࢆ⏕ࡌࡓ☢Ẽ⛛ᗎ┦ࡀほࡉࢀࡓࡀࠊx  ࡛ࡣప ࡛ࡶᖖ☢ᛶ┦ࡢࡳ࡛࠶ࡗ
ࡓࠋࡍ࡞ࢃࡕࠊx  ࡢ㉸ఏᑟ┦࡛ࡣ☢Ẽ⛛ᗎࢆ⏕ࡌ࡞࠸ࡇ࡜ࢆ♧ࡍ⤖ᯝࡀᚓࡽࢀࡓࠋ୍᪉ࠊx  ࡛ࡣ㉸ఏᑟࢆ♧ࡍࡀࠊ☢Ẽ⛛ᗎ┦ࡶ⏕ࡌ࡚࠾ࡾࠊඹᏑ
ࡍࡿ┦ࡀᏑᅾࡍࡿ࡜࠸࠺⤖ᯝࡀᚓࡽࢀࡓࠋࡲࡓࠊ☢
Ẽ⛛ᗎࢆ♧ࡍ┦࡛ࡣࠊᑡࡋ㧗 ഃࡢ ᗘ㡿ᇦ࡟࠾࠸࡚⥺ᖜࡢᗈࡀࡾࡀほ ࡉࢀࡓࠋࡇࢀࡣࠊࢿ࣐ࢸ࢕ࢵ
ࢡ⛛ᗎ≧ែ࡜ࡋ࡚ண᝿ࡉࢀ࡚࠸ࡿ┦ࢆほ ࡋࡓࡶࡢ࡜᥎ ࡉࢀࡿ>@ࠋࡉࡽ࡟ᮏ◊✲࡛ࡣࠊᙉ☢ሙୗ࣓ࢫࣂ࢘࢔࣮ ᐃ࡟ࡼࡾ☢ᛶ࡟ࡘ࠸࡚ࡢࡼࡾヲ⣽࡞᝟ሗࢆᚓࡿࡇ࡜ࢆ┠ᣦࡋࡓࠋ)LJ ࡣ %D)H$V ࡢ☢ሙୗ࡛ࡢ࣓ࢫࣂ࢘࢔࣮ࢫ࣌
ࢡࢺ࡛ࣝ࠶ࡿࠋ☢Ẽ㌿⛣Ⅼࡼࡾప ࡢ☢Ẽ⛛ᗎ≧ែ࡛ࡣࠊ☢ሙ୰࡟࠾ࡅࡿ཯ᙉ☢ᛶయࡢ᣺⯙࠸ࢆ♧ࡍࢫ࣌ࢡࢺࣝࡢᙧࡀほ ࡉࢀࡓࡇ࡜࠿ࡽࠊ☢Ẽ⛛ᗎࡀ཯ᙉ☢ᛶ࡛࠶ࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓࠋࡲࡓ☢Ẽ㌿⛣Ⅼࡼࡾ㧗 ࡛ࡣࠊᖖ☢ᛶࡢ᣺⯙࠸ࢆ♧ࡍࡇ࡜ࡢ☜ドࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡲࡓࠊ☢Ẽ㌿⛣Ⅼࡼࡾࡸࡸ㧗 ഃࡢ⥺ᖜࡢᗈࡀࡾࡀ⏕ࡌࡿ㡿ᇦ࡛ࡣࠊ⥺ᖜࡢᗈࡀࡾࡣ
ᅄᴟᏊศ⿣࡟㉳ᅉࡍࡿࡇ࡜ࢆ♧ࡍ⤖ᯝࡀᚓࡽࢀࠊࢿ
࣐ࢸ࢕ࢵࢡ⛛ᗎ≧ែࡀᵓ㐀ࡢᑠࡉ࡞␗᪉ᛶ࡟㉳ᅉࡍࡿ࡜࠸࠺ண᝿࡜ࡶ▩┪ࡋ࡞࠸⤖ᯝࢆᚓࡿࡇ࡜ࡀ࡛ࡁ
ࡓ>@ࠋ 1L ࣓ࢫࣂ࢘࢔࣮ศග ᐃࡢヨࡳ
㸦ி኱⅔ ᑠᯘᗣᾈ㸧
1L ࡣࡑࡢ ᐃ࡟ࡘ࠸࡚ࡢ㟂せࡀ኱ࡁ࠸࡟ࡶ࠿࠿ࢃ
ࡽࡎࠊ㛗ᑑ࿨⥺※ࡀᚓࡽࢀ࡞࠸ࡓࡵࠊࡇࢀࡲ࡛࠶ࡲ
ࡾ࣓ࢫࣂ࢘࢔࣮ศගࡀ⾜ࢃࢀ࡚࠸࡞࠿ࡗࡓࠋࡑࡇ࡛ࠊ
.85 ࡟࠾࠸࡚ࡑࡢ ᐃ᪉ἲࡢ☜❧ࢆ⾜ࡗࡓࠋᮏ◊✲䢳䢰䢲䢲䢴䢲䢲䣍䢢䢲䣖

䢲䢰䢻䢷䢴䢲䢲䣍䢢䢳䢲䣖

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䢲䢰䢻䢷䢳䢸䢲䣍䢢䢳䢲䣖

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䢲䢰䢻䢸

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䣖䣴䣣䣰䣵䣯䣫䣵䣵䣫䣱䣰

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䢲䢰䢻䢹
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䢲䢰䢻䢲

䢴䢰䢷䣍䢢䢳䢲䣖

䢪䣤䢫䢪䣣䢫䣄䣣䣈䣧䢴䣃䣵䢴䢯䢶䢯䢴䢲䣘䣧䣮䣱䣥䣫䣶䣻䢢䢪䣯䣯䢱䣵䢫

䢴

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䢸

䣘䣧䣮䣱䣥䣫䣶䣻䢢䢪䣯䣯䢱䣵䢫)LJ  7\SLFDO 0|VVEDXHU VSHFWUD RI %D)H$V D
ZLWKRXW DSSOLHG PDJQHWLF ILHOG DQG E ZLWK DSSOLHG
PDJQHWLF ILHOGVRI 7㻙 㻡㻤㻌㻙

)LJ  ࣛ࢖ࢼࢵࢡ↷ᑕᐊ࠿ࡽࣉࡢタ⨨ࠋᐃᐊ࡬ࡢ㍺㏦ࣃ࢖࡛ࡣࠊࣛ࢖ࢼࢵࢡࡢ㟁Ꮚ⥺↷ᑕ࡟ࡼࡾ Ȗ ⥺ࢆࢥࣥࣂ࣮ࢱࢆ⏝࠸࡚Ⓨ⏕ࡉࡏࠊ J Q ཯ᛂࠊ J Q ཯ᛂࠊ J S
཯ᛂ࡞࡝ࢆ⏝࠸࡚ࠊ࣓ࢫࣂ࢘࢔࣮ศග࡛⥺※࡜ࡍࡿ᰾✀ࡢ⏕ᡂࡢᐇドࢆ⾜ࡗࡓࠋᴟᑡ㔞ࡢヨᩱ㸦㹼 PJ㸧
࡟ᑐࡋ࡚↷ᑕࢆ⾜࠸ࠊ┠ⓗࡢ᰾✀ࡀຠ⋡ⓗ࡟ᚓࡽࢀࡿࡇ࡜ࡢ☜ㄆࢆ⾜ࡗࡓࠋ1L ࣓ࢫࣂ࢘࢔࣮ศග⏝ࡢ⥺※࡜ࡋ࡚ࡣࠊ&R ࡜ &X ࡢ  ᰾✀ࡀ࠶ࡾࠊࡑࢀࡒ
ࢀ 1L J S &R ཯ᛂࠊ&X J Q &X ཯ᛂ࡛⏕ᡂࡍࡿࠋ
&X ࡣ࣓ࢫࣂ࢘࢔࣮Ȗ ⥺ࢆᨺฟࡍࡿศᒱẚࡀ  ࡜ᑠࡉ࠸ࡀ༙ῶᮇࡀ  ᫬㛫࡜ࡸࡸ㛗࠸ࠊ&R ࡣ Ȗ ⥺ࡢศᒱẚࡀ  ࡜㧗࠸ࡀ༙ῶᮇࡀ  ᫬㛫ࡋ࠿࡞ࡃࠊ
ࡑࢀࡒࢀ୍㛗୍▷ࡀ࠶ࡿࡓࡵ୧᪉ࢆస〇ࡋ࡚ẚ㍑ࢆ
⾜ࡗࡓࠋࡇࢀࡽࡢ᰾✀ࡢ༙ῶᮇࡀ▷࠸ࡓࡵࠊ)LJ ࡢࡼ࠺࡞ࣛ࢖ࢼࢵࢡ↷ᑕᐊ࠿ࡽ ᐃᐊ࡬ࠊ↷ᑕヨᩱࢆ
㎿㏿࡟㍺㏦ࡍࡿࡓࡵࡢࣃ࢖ࣉࢆタ⨨ࡍࡿࡇ࡜࡛ࠊ▷࠸༙ῶᮇࡢヨᩱࢆຠ⋡ࡼࡃ ᐃࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡼ
࠺࡟࡞ࡗࡓࠋࣛ࢖ࢼࢵࢡ↷ᑕ࡛సᡂࡋࡓ &R ࠾ࡼࡧ&X ⥺※ࢆ༙ᑟయ᳨ฟჾ࡛ ᐃࡋࡓ࡜ࡇࢁࠊ࡝ࡕࡽ
ࡶ┠ⓗࡢ᰾✀ࡀ⏕ᡂࡋ࡚࠸ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋ &X
ࡣ」㞧࡞ᔂቯᵝᘧࢆ཯ᫎࡋ࡚ከᩘࡢ Ȗ ⥺ࡀほ ࡉࢀࡓࡢ࡟ᑐࡋࠊ&R ࡛ࡣ࡯ࡰ┠ⓗ࡜ࡍࡿ Ȗ ⥺ࡢࡳࡢ⥺※࡜࡞ࡗ࡚࠾ࡾ⏕ᡂ㔞ࡶ༑ศ࡛࠶ࡿࡇ࡜ࡀ☜ㄆ࡛ࡁࡓࠋࡲࡓࠊ࣓ࢫࣂ࢘࢔࣮ศගࡢ⥺※࡜ࡍࡿࡓࡵ࡟ࡣ
⥺※ࡀ☢Ẽศ⿣࡞࡝ࡢ㉸ᚤ⣽ᵓ㐀ࢆᣢࡓ࡞࠸ࡇ࡜ࡀ
࡯ࡰᚲ㡲࡛࠶ࡿࡓࡵࠊ☢ᛶࢆᣢࡓ࡞࠸ 1L9 ྜ㔠ࡢ≧ែ࡛↷ᑕࢆ⾜࠸࣓ࢫࣂ࢘࢔࣮ศග ᐃࡢ㞀ᐖ࡜࡞ࡿ Ȗ ⥺ࢆᨺฟࡍࡿ᰾✀ࡀ 9 ࠿ࡽ⏕ᡂࡋ࡞࠸ࡇ࡜ࢆ☜ㄆࡋࡓࠋࡇࢀࡽ࡟ࡼࡗ࡚ࠊ.85 ࡟࠾ࡅࡿ௒ᚋࡢ 1L࣓ࢫࣂ࢘࢔࣮ศගࡢྍ⬟ᛶࡀ኱ࡁࡃ㛤࠿ࢀࡓࡶࡢ࡜
⪃࠼ࡽࢀࡿࠋ ⓑ㔠୍ḟඖ㘒యࡢ , ࣓ࢫࣂ࢘࢔࣮ศග࡟ࡼࡿ◊✲㸦ᮾ໭኱ ஭ཱྀᘯ❶ࠊி኱⅔ ໭ᑿ┿ྖ㸧ᮏ◊✲ࡣࠊᨃ୍ḟඖࣚ࢘⣲ᯫᶫⓑ㔠」᰾㘒య)LJ  ,0RVVEDXHUVSHFWUDRI. FLV+1&+&+ &+&+1+ >3W SRS ,@ā+2 ā+
2 DQGGHK\GUDWHGVDPSOH  DW.

㻙 㻡㻥㻌㻙

00; 㘒య ࡢⓑ㔠ࡢ㟁Ꮚ≧ែࢆ , ࣓ࢫࣂ࢘࢔࣮ศ
ග࡟ࡼࡗ࡚᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ◊✲࡛࠶ࡿࠋⓑ㔠 0 ࡜ࣚ࢘⣲ ; ࡢ㟁Ꮚ≧ែࡣࠊ௨ୗࡢ  ✀㢮ࡢ≧ែࡀ࠶ࡾࠊ㓄఩Ꮚ࡞࡝ࡢ࿘ᅖࡢ⎔ቃ࡟ࡼࡗ࡚
ኚ໬ࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋ
D 00;00;
E 00;00;
F 00;00;
G 00;00;ࡋ࠿ࡋ࡞ࡀࡽࠊࡇࢀࡽࡢෆࡢ࡝ࡢ≧ែ࡟࠶ࡿࡢ࠿
ࢆ≉ᐃࡍࡿࡇ࡜ࡣ㞴ࡋ࠿ࡗࡓࠋᮏ◊✲࡛ࡣࠊ00;㘒య࡟ࡘ࠸࡚ࣚ࢘⣲ࡢ㟁Ꮚ≧ែ࠿ࡽ࡝ࡢࡼ࠺࡞౯ᩘ
ศᕸ࡟࡞ࡗ࡚࠸ࡿࡢ࠿ࢆ᥎ᐃࡍࡿࡇ࡜࡛ࠊ㟁Ꮚ≧ែࢆ≉ᐃࡍࡿࡇ࡜࡟ᡂຌࡋࡓࠋ
. FLV+1&+&+ &+&+1+ >3W SRS ,@ā+2 ā+2 ࠾ࡼࡧࡑࡢ↓Ỉ≀  ࡟࠾࠸࡚ࡣࠊ)LJ ࡢࡼ࠺࡞ , ࣓ࢫࣂ࢘࢔࣮ࢫ࣌ࢡࢺࣝࡀᚓࡽࢀࡓࠋࡇࡇ࡛
SRS  3+2±࡛࠶ࡿࠋࢫ࣌ࢡࢺࣝ࠿ࡽࣚ࢘⣲ࡢ౯ᩘࡀ ࡢ୍ࡘࡢࢧ࢖ࢺ࡛࠶ࡿࡇ࡜ࡀほ ࡉࢀࠊⓑ㔠ࡢ౯ᩘࡀ㟁ⲴᐦᗘἼ≧ែ㸦㸦E㸧ࡢ≧ែ㸧࡟࡞ࡗ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋ
ࡉࡽ࡟ࠊ㢮ఝࡢ໬ྜ≀࡟ࡘ࠸࡚ࡶ ᐃࢆ⾜࠸ࠊࡑࡢ㟁Ꮚ≧ែࡢ≉ᐃࡸࠊࣚ࢘⣲ࡢ౯ᩘ࡜ⓑ㔠ࣚ࢘⣲㛫ࡢ㊥㞳ࡢ㛵ಀ࡟ࡘ࠸࡚ࡢ▱ぢࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡓ>@ࠋ &H)H[&U[32 ࡢᙉ☢ᛶ㔞Ꮚ⮫⏺Ⅼࡢ )H ࣓ࢫࣂ࢘࢔࣮ຠᯝ࡟ࡼࡿ◊✲㸦៞ᛂ኱ ⚄ཎ㝧୍㸧

)LJ )H0RVVEDXHUVSHFWUDRI&H)H&U32㕲⣔㉸ఏᑟయ㛵㐃≀㉁࡛࠶ࡿ &H)H[&U[32 ࡣప࡛ᙉ☢ᛶⓗ࡞᣺⯙࠸ࡀぢࡽࢀࡿࡀࠊࡑࡢ☢ᛶࡢ㉳※࡟ࡘ࠸࡚ࡣࡼࡃࢃ࠿ࡗ࡚࠸࡞࠸ࠋᮏ◊✲࡛ࡣࠊ )H࣓ࢫࣂ࢘࢔࣮ศග࡟ࡼࡾ㕲ࡢ㟁Ꮚ≧ែࡢ≉ᐃࢆ⾜ࡗࡓࠋ)LJ  ࡟ x  ࡢ࣓ࢫࣂ࢘࢔࣮ࢫ࣌ࢡࢺࣝࢆ♧ࡍࠋ . ࡢప ࡲ࡛㕲ࡣ☢Ẽศ⿣ࢆ⏕ࡌ࡚࠸࡞࠸ࡇ
࡜࠿ࡽࠊ☢Ẽ㌿⛣ࢆ♧ࡋ࡚࠸࡞࠸ࡇ࡜ࡀࢃ࠿ࡿࠋ.
࡟࠾࠸࡚ࡣࢃࡎ࠿࡞⥺ᖜࡢᗈࡀࡾ࡜ᅄᴟᏊศ⿣ࡢኚ໬ࡀぢࡽࢀࡓࡀࠊ&H ࡢᙉ☢ᛶ㌿⛣ࢆ཯ᫎࡋ࡚࠸ࡿ࡜᥎ ࡉࢀࡿࠋࡇࢀࡽࡢࡇ࡜࠿ࡽࠊ&H)Hx&Ux32 ࡢᙉ☢ᛶⓗ࡞ᛶ㉁ࡣ㕲࠿ࡽ⏕ࡌ࡚࠸ࡿࡶࡢ࡛ࡣ࡞ࡃࠊ୺
࡜ࡋ࡚ &H ࡟ࡼࡾ⏕ࡌ࡚࠸ࡿࡇ࡜ࡀ᥎ ࡉࢀࠊࡇࡢ⣔࡛♧၀ࡉࢀ࡚࠸ࡿᙉ☢ᛶ㔞Ꮚ⮫⏺Ⅼ࡟ࡘ࠸࡚ࡢ㆟ㄽࢆ㐍ᒎࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡓࠋ>@ ࣐ ࣝ ࢳ ࣇ ࢙ ࣟ ࢖ ࢵ ࢡ ≀ ㉁ *D)H2 ࠊ &X)H2 ࠊ&X)H*D2 ࡢ )H ࣓ࢫࣂ࢘࢔࣮ຠᯝ࡟ࡼࡿ◊✲㸦ᖇி኱ ୰ᮧ┿୍㸧☢Ẽ⛛ᗎ࡜ᙉㄏ㟁⛛ᗎࡢᛶ㉁ࢆేࡏᣢࡘ࣐ࣝࢳࣇ
࢙ࣟ࢖ࢵࢡ≀㉁࡛࠶ࡿ *D)H2 ࡟ࡘ࠸࡚ࠊప ᙉ☢ሙୗࡢ )H ࣓ࢫࣂ࢘࢔࣮ศගࢆ⾜ࡗࡓࠋF ㍈᪉ྥ࡟☢
ሙࢆ࠿ࡅࡓ᫬࡟ࡣ )H ࡢᅄᴟᏊศ⿣ࡀ኱ࡁࡃቑຍࡋ
ࡓࡀࠊࡇࢀࡣ☢ሙ༳ຍ࡟ࡼࡗ࡚ E ㍈᪉ྥ࡟ )H ཎᏊࡢ఩⨨ࡀࡎࢀࡓࡓࡵ࡜⪃࠼ࡽࢀࡿࠋE ㍈᪉ྥ࡟☢ሙࢆ࠿ࡅࡓ᫬࡟ࡣࡇࡢࡎࢀࡀ⏕ࡌ࡞࠸ࡓࡵࠊᅄᴟᏊศ⿣

ࡢ኱ࡁ࡞ኚ໬ࡣほ ࡉࢀ࡞࠿ࡗࡓ>@ࠋ&X)H2 ࠾ࡼࡧ &X)H*D2 ࡟ࡘ࠸࡚ࡶప ᙉ☢ሙୗ )H ࣓ࢫࣂ࢘࢔࣮ศග ᐃࢆ⾜ࡗࡓࠋ)LJ ࡟&X)H2 ࡢ  . ࡛ࡢ☢ሙୗ࣓ࢫࣂ࢘࢔࣮ࢫ࣌ࢡࢺࣝ
ࢆ♧ࡍࠋ㹼 7 ࡢእ㒊☢ሙୗ࡛⏕ࡌࡿᙉㄏ㟁୙ᩚྜ┦㸦)(,&㸧࡛ࡣ  㠃ෆ࡛ F ㍈࠿ࡽ⣙   ᗘ
ࡢゅᗘ࡛ࢫࣆࣥࡀศᕸࡋ࡚࠸ࡿࣔࢹ࡛ࣝゎ㔘ࡍࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡇࡢࢫࣆࣥ㓄⨨ࡣ⌮ㄽⓗ࡟ᥦ᱌ࡉࢀ࡚
࠸ࡿ³FRPSOH[ QRQFROOLQHDU &1& ´ࢫࣆࣥ㓄⨨ࣔࢹࣝ࡜㢮ఝࡍࡿࡶࡢ࡛࠶ࡗࡓࠋ)(,& ┦࡛ࡣࠊእ㒊☢ሙࡀ
 7 ௨ୗࡢ FROOLQHDUVXEODWWLFH ┦ 6/ ࡸࠊ 7 ௨ୖ
ࡢ FROOLQHDUVXEODWWLFH ┦ 6/ ࡼࡾࠊ࢔࢖ࢯ࣐࣮ࢩࣇ
ࢺࡀ኱ࡁࡃࠊᅄᴟᏊศ⿣ࡸᖹᆒෆ㒊☢ሙࡣᑠࡉࡃ࡞
ࡿࡇ࡜ࡀศ࠿ࡗࡓࠋࡲࡓእ㒊☢ሙࢆኚ࠼ࡿࡇ࡜࡟ࡼ
ࡿෆ㒊☢ሙࡢኚ໬ࡶほ ࡉࢀࡓࠋࡇࢀࡽࡢኚ໬ࡣ࠾
ࡑࡽࡃࢫࣆࣥ㌶㐨┦஫స⏝࡟ࡼࡿ )H࢖࢜ࣥࡢ㟁Ꮚ≧ែࡢኚ໬ࢆ཯ᫎࡋ࡚࠸ࡿࡶࡢ࡜⪃࠼ࡽࢀࡿ>@ࠋཧ⪃ᩥ⊩>@ 6 .LWDR 0 .XURNX]X < .RED\DVKL 0 6DLWR 6
6HWR.855,3URJ5HSS>@ 6.LWDR0.XURNX]X<.RED\DVKL66HWR.85
5,3URJ5HSS>@ + ,JXFKL 6 .LWDR 0 6HWR 6 7DNDLVKL 0 <DPD
VKLWD 'DOWRQ7UDQV   
>@ 7 2NDQR 6 .LWDR 0 6HWR 7 $WRX 0 ,WRK 0
0DWRED<.DPLKDUD -$SSO3K\V  (>@ 6 1DNDPXUD < .RED\DVKL 6 .LWDR 0 6HWR $
)XZD -3K\V&RQI6HU  
>@ 6 1DNDPXUD < .RED\DVKL 6 .LWDR 0 6HWR $
)XZD1 7HUDGD - 3K\V6RF-SQ  

)LJ )H0RVVEDXHUVSHFWUDRI&X)H2 DW . ZLWKDSSOLHGPDJQHWLFILHOGV$GYDQFHGDSSOLFDWLRQV RIPXOWLHOHPHQW0|VVEDXHUVSHFWURVFRS\ WRFRQGHQVHGPDWWHU
0DNRWR6HWR6KLQML.LWDR<DVXKLUR.RED\DVKL0DNLQD6DLWR7DNXPL.XERWD5\R0DVXGD0DVD\XNL.XURNX]X<RLFKL.DPLKDUD
6KLQLFKL1DNDPXUD.HLML6KLQRGD1RULPLFKL.RMLPD7DNXVKL<RNR\DPD0DVDKLWR.RGHUD,NX\D<DPDGD.RXML)XMLWD0DVDVKL7DNDKDVKL0DVDIXPL0DWVXVKLWD<DVXKLNR<DPDPRWR+LURNR<RNRWD
VHWR#UULN\RWRXDFMS㻙 㻢㻜㻌㻙

㻔㻿㻝㻕⺮ⓑ㉁୰ࡢ '࢔࣑ࣀ㓟ࢆᣦᶆ࡜ࡋࡓ⪁໬ࡢᇶ♏◊✲
㸦/࢔࣑ࣀ㓟࣮࣡ࣝࢻ࡟࠾ࡅࡿࣃࣛ࢟ࣛࣜࢸ࢕ࡢᴫᛕࡢ㔜せᛶ㸧㸦ி኱ཎᏊ⅔㸧‫⸨ۑ‬஭⣖Ꮚ㸯㸬ࡣࡌࡵ࡟㸸⺮ⓑ㉁ࡣ 20 ✀㢮ࡢࡑࢀࡒࢀᛶ㉁ࡢ␗
࡞ࡿ࢔࣑ࣀ㓟ࡀ㔜ྜࡋࠊᅛ᭷ࡢ❧యᵓ㐀ࢆ᭷ࡍࡿࡇ
࡜࡟ࡼࡾከᵝ࡞ᶵ⬟㸦⏕యෆ໬Ꮫ཯ᛂࡢゐ፹࡜ࡋ࡚ࡢ㓝⣲ࠊ㓟⣲ࢆ㐠ᦙࡍࡿ࣊ࣔࢢࣟࣅࣥࠊᢠయࡸ࣍ࣝ
ࣔࣥࠊࢥ࣮ࣛࢤࣥ࡞࡝ࡢᨭᣢయ࡜ࡋ࡚ࡢᶵ⬟ࠊ࢔ࢡࢳࣥࠊ࣑࢜ࢩࣥ࡞࡝ࡢ㐠ືࢆࡘ࠿ࡉ࡝ࡿࡶࡢࠊ᰾㓟⤖ྜ⺮ⓑ㉁࡞࡝ࠋ㸧ࢆᢸࡗ࡚࠸ࡿࠋ⺮ⓑ㉁ᵓᡂ࢔࣑ࣀ
㓟ࡢ࠺ࡕࠊࢢࣜࢩࣥࢆ㝖࠸ࡓ 19 ✀㢮ࡢ࢔࣑ࣀ㓟࡟ࡣ
L-య࡜ D-యࡢ㙾ീ␗ᛶయࡀᏑᅾࡍࡿࠋ
L-య࡜ D-యࡣᕥᡭ࡜ྑᡭࡢࡼ࠺࡞㛵ಀ࡟࠶ࡾࠊ஫࠸࡟
㔜ࡡྜࢃࡍࡇ࡜ࡣ
࡛ࡁ࡞࠸ࠋࡇࢀࡽ
ࡣගᏛⓗᛶ㉁ࢆ㝖ᅗ 1 L-Asp ࡜ D-Aspࡁ≀⌮ⓗ໬Ꮫⓗᛶ㉁ࡣ඲ࡃྠࡌ࡛࠶ࡿࠋ⏕࿨ࡀㄌ⏕ࡍࡿ๓ࡢཎጞᆅ⌫ୖ࡛ࡣ L -యࠊD-యࡢ࢔࣑ࣀ㓟ࡀ➼㔞ྜᡂࡉࢀࡓ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡀࠊ໬Ꮫ㐍໬ࡢ㐣⛬࡛ D-࢔࣑ࣀ㓟ࡣ᤼㝖ࡉࢀࠊL-࢔࣑ࣀ㓟ࡢࡳࡀ㔜ྜࡋ࡚⺮ⓑ㉁࡜࡞ࡾࠊ
௒᪥ࡢ⏕࿨ୡ⏺ࡀ⏕ࡲࢀࡓ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ࡞ࡐࠊ
D-࢔࣑ࣀ㓟ࡀ᤼㝖ࡉࢀ L -࢔࣑ࣀ㓟ࡀ㑅ᢥࡉࢀࡓࡢ࠿
ࡣ⏕࿨ࡢ㉳ཎ࡟࠾࠸࡚᭱኱ࡢㅦ࡛࠶ࡿࠋࡋ࠿ࡋࠊ࢔
࣑ࣀ㓟࠿ࡽཎጞ⺮ⓑ㉁࡬ࡢ㐍໬ࡢ㐣⛬࡛ࡣࠊ L-యࠊ
D-యࡢ࢔࣑ࣀ㓟ࡀΰ↛୍య࡜࡞ࡗࡓ࣏ࣜ࣌ࣉࢳࢻ࡛
ࡣ↓ᩘࡢࢪ࢔ࢫࢸ࣐࣮ࣞ࢜ࡀᙧᡂࡉࢀ࡚ࡋࡲ࠺ࡢ࡛ࠊ
❧యᵓ㐀ᙧᡂ࡟ࡣ୙฼࡛࠶ࡾࠊ࡝ࡕࡽ࠿୍᪉ࡢ∦ᡭᵓ㐀㸦࣍ࣔ࢟ࣛࣜࢸ࢕࣮)ࡢ☜❧ࡀᚲ㡲࡛࠶ࡗࡓࡇ࡜
ࡣᐜ᫆࡟⌮ゎ࡛ࡁࡿࠋཎጞᆅ⌫ୖ࡛ࡣ L -࢔࣑ࣀ㓟ࡢ㑅ᢥ→L-࢔࣑ࣀ㓟ࡢ㔜ྜ→L-࢔࣑ࣀ㓟ࡢࡳ࠿ࡽ࡞ࡿ
ᑠࡉ࡞࣌ࣉࢳࢻ→L-࢔࣑ࣀ㓟ࡢࡳࡢཎጞ⺮ⓑ㉁→→⺮ⓑ㉁→⏕࿨ࡢㄌ⏕࡜㐍໬ࡋࡓ࡜⪃࠼ࡽࢀ࡚࠸ࡿࠋ
ࡋࡓࡀࡗ࡚ࠊ⏕࿨⛉Ꮫࡢ◊✲㡿ᇦ࡛ࡣ࢔࣑ࣀ㓟࡜࠸࠼ࡤ L -యࡀᙜࡓࡾ๓࡛࠶ࡾࠊD-࢔࣑ࣀ㓟ࡣ⏕య࡟ࡣ↓⦕࡞ࡶࡢ࡜ᐃ⩏ࡉࢀ 30 ᖺ࡯࡝๓࡟ࡣࠊ࡯࡜ࢇ࡝◊✲ᑐ㇟࡟ࡣ࡞ࡗ࡚࠸࡞࠿ࡗࡓࠋ
➹⪅ࡣᮾி་⛉ṑ⛉኱Ꮫ࡛༤ኈࡢᏛ఩ࢆྲྀᚓᚋࠊ
⟃Ἴ኱Ꮫ໬Ꮫ⣔ࡢཎ⏣㤾ᩍᤵࡢ◊✲ᐊ࡛ 3 ᖺ㛫ࡢ௵ᮇ௜ࡁ࣏ࢫࢺࡢ⫋ࢆᚓࡓࠋࡇࡇ࡛㛤ጞࡋࡓ◊✲ࡀ➹⪅ࡢࣛ࢖ࣇ࣮࣡ࢡ࡜࡞ࡗࡓ⺮ⓑ㉁୰ࡢ D-࢔࣑ࣀ㓟ࡢ◊✲࡛࠶ࡿࠋཎ⏣◊✲ᐊ࡟࠾࠸࡚ࡣ୙ᩧྜᡂࠊ㝹▼ࡢ୰ࡢ㐟㞳࢔࣑ࣀ㓟ࡢගᏛ␗ᛶయศᯒࠊ࣑࣮ࣛࡢᨺ
㟁ᐇ㦂ࡢࡼ࠺࡞໬Ꮫ㐍໬◊✲ࢆ⾜ࡗ࡚࠸ࡓࠋ◊✲ᐊࡢ࣓ࣥࣂ࣮ࡣ᭷ᶵྜᡂࠊศᯒ໬Ꮫࠊᆅ⌫໬Ꮫࢆࣂࢵ
ࢡࢢࣛ࢘ࣥࢻ࡟ࡋ࡚࠸ࡿேࡓࡕ࡛ࠊ⏕໬Ꮫࢆᑓ㛛࡟ࡍࡿࡶࡢࡀ࠸࡞࠿ࡗࡓࠋཎ⏣ᩍᤵ࠿ࡽࡣࠊ◊✲ᐊࡢ㻙 㻢㻝㻌㻙

ࢸ࣮࣐࡜ྜ⮴ࡍࡿࡼ࠺࡞⏕໬Ꮫ◊✲ࢆ❧ࡕୖࡆ࡚࡯
ࡋ࠸࡜ゝࢃࢀࡓࠋࠕ3 ᖺ࡜࠸࠺௵ᮇ௜ࡁ࣏ࢫࢺ࡞ࡢ࡟
ࡑࡢᵝ࡞₍↛࡜ࡋࡓࡇ࡜ࢆゝࢃࢀ࡚ࡶ….ࠖ࡜ᛮ࠸ࠊ
ࡋࡤࡽࡃࢸ࣮࣐タᐃ࡟ᝎࢇ࡛࠸ࡓࠋࡋ࠿ࡋࠊ◊✲ᐊෆ࡟ṑࡸ㦵ࡢ໬▼୰ࡢ D-࢔࣑ࣀ㓟㔞ࢆ ᐃࡋ࡚ᖺ௦
ᐃࢆࡋ࡚࠸ࡿேࡀ࠸ࡓࡢࡀࣄࣥࢺ࡟࡞ࡗࡓࠋ⺮ⓑ㉁୰ࡢ࢔࣑ࣀ㓟ࡣ⏕ࡁ࡚࠸ࡿ㛫ࡣࡍ࡭࡚ D-య࡛࠶ࡿࡀࠊṚࢇ࡛໬▼࡟࡞ࡿ࡜㛗࠸ᖺ᭶ࢆ࠿ࡅ࡚ D-యࡀቑຍࡋࠊࡑࡢ㔞ࡣᖺᩘ࡟ᑐࡋ࡚ẚ౛ࡋ࡚࠾ࡾࠊ཯ᛂࡣ
୍ḟ཯ᛂ࡜ࡋ࡚ྲྀࡾᢅ࠺ࡇ࡜ࡀ࡛ࡁࠊ཯ᛂ㏿ᗘᐃᩘࢆ⟬ฟ࡛ࡁࡿࠋᙼࡽࡣࡇࢀࢆ฼⏝ࡋ࡚ᖺ௦ ᐃࢆࡋ࡚࠸ࡓࠋ༤ኈㄢ⛬࡛⺮ⓑ㉁ࡢඛ➃◊✲ࢆࡸࡗ࡚࠸ࡓ
➹⪅࡟࡜ࡗ࡚ࡣࠊࠕ┠࠿ࡽ㫣࡛ࠖࠊ⏕࿨య㸻L -࢔࣑ࣀ㓟ࡢ∦ᡭᵓ㐀ୡ⏺࡜࠸࠺࠸ࢃࡤᙜࡓࡾ๓ࡢࡇ࡜࡟ึ
ࡵ࡚Ẽࡀ௜࠸ࡓࠋࡋ࠿ࡶ໬▼◊✲࡛ࡣ࢔࣑ࣀ㓟ࡢ✀㢮࡟ࡼࡾࣛࢭ࣑໬(ࡇࡇ࡛ࡣࠊL-య࠿ࡽ D-య࡬ࡢኚ໬)ࡢ㏿ᗘᐃᩘࡀ␗࡞ࡿࡢࢆ฼⏝ࡋ࡚ࠊఱ༑୓ᖺ๓ࡢ໬
▼ヨᩱࡢᖺ௦ࢆ ᐃࡍࡿ࡜ࡁࡣࣛࢭ࣑໬㏿ᗘࡢ㐜࠸ࣟ࢖ࢩࣥࠊ༓ᖺ๓ࡃࡽ࠸ࡢ᫬ࡣࣛࢭ࣑໬㏿ᗘࡢ㏿࠸࢔ࢫࣃࣛࢠࣥ㓟(Asp)࡜࠸࠺ࡼ࠺࡟࢔࣑ࣀ㓟ࡢ✀㢮ࢆ౑࠸ศࡅ࡚ ᐃࡋ࡚࠸ࡓࠋAsp ࡢࣛࢭ࣑໬ࡣ඲࢔
࣑ࣀ㓟ࡢ୰࡛᭱ࡶ㏿ࡃࠊ100 ᖺࡃࡽ࠸࡛ࡶᩘ㸣ࡢ
D-Asp ࡣ᳨ฟ࡛ࡁࡑ࠺࡛࠶ࡗࡓࠋࡑ࠺࡞ࡿ࡜ࠊ80-100ṓࡃࡽ࠸ࡢࣄࢺࡢຍ㱋⤌⧊ࡢ⺮ⓑ㉁࡛ࡶ D-Asp ࡀ᳨ฟ࡛ࡁࡿྍ⬟ᛶࡀ࠶ࡿࠋࡓࡔࠊ⏕ࡁ࡚࠸ࡿࣄࢺࡢ⺮ⓑ㉁࡛ࡣ᪂㝞௦ㅰ࡛ྂ࠸⺮ⓑ㉁ࡣධࢀ᭰ࢃࡗ࡚ࡋࡲ
࠺ࠋࡑࡇ࡛ࠊ௦ㅰࡢ࡞࠸⤌⧊ࡢ⺮ⓑ㉁ࢆศᯒࡍࢀࡤࠊ
D-Asp ࢆ᳨ฟ࡛ࡁࡿ࠿ࡶࡋࢀ࡞࠸࡜⪃࠼ࠊ௦ㅰࡀ࡞
ࡃࠊ⺮ⓑ㉁ࡢ㔞ࡀ㇏ᐩ࡞║ࡢỈᬗయࢆヨᩱ࡜ࡋ࡚ࠊ
ࡇࢀࢆศᯒࡋࡼ࠺࡜᳨ウࢆ㛤ጞࡋࡓࠋ࡜ࡇࢁࡀࠊ➹⪅ࡀ⪃࠼ࡿࡼ࠺࡞ࡇ࡜ࡣㄡࡶࡀ⪃࠼ࡘࡃࡇ࡜࡛ࠊ࢔
࣓ࣜ࢝ࡢ໬▼Ꮫ⪅ࡀࠊࣄࢺࡢ║ࡢ୰ࡢ D-Asp ࢆ᳨ฟࡋ࡚ࡑࡢ㏿ᗘᐃᩘࢆⓎ⾲ࡋ࡚࠸ࡓࡇ࡜ࡀࢃ࠿ࡗࡓࠋ
ࡇࢀ࡟ࡣⴠ⫹ࡋࡓࡀࠊᙼࡽࡣỈᬗయࢆ୸ࡈ࡜ࡍࡾࡘ
ࡪࡋ࡚ຍỈศゎࡋࠊᚓࡽࢀࡓ࢔࣑ࣀ㓟ࡢගᏛ␗ᛶศ
ᯒࢆࡋࡓࡔࡅ࡛◊✲ࢆ⤊ࢃࡽࡏ࡚࠸ࡓࠋ໬▼ヨᩱ࡜ࡣ␗࡞ࡾࠊ⏕ࡁ࡚࠸ࡿ㛫ࡣ⺮ⓑ㉁ࡢ✀㢮ࠊ⺮ⓑ㉁୰
ࡢ Asp ṧᇶࡢ㒊఩࡟౫Ꮡࡋ࡚ࠊࣛࢭ࣑໬ࡢࡋࡸࡍࡉ
ࡣྛࠎ␗࡞ࡿࡣࡎ࡛࠶ࡿࠋࡑࢀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ
࡟ࡣỈᬗయࢆ୸ࡈ࡜ࡍࡾࡘࡪࡋࠊ໬▼Ꮫ⪅ࡢሗ࿌ࡢࡼ࠺࡞඲⺮ⓑ㉁ࢆຍỈศゎࡋࡓศᯒ᪉ἲ࡛ࡣࠊỈᬗయ୰ࡢ࡝ࡢ⺮ⓑ㉁ࡢ࡝ࡢ Asp ࡀࣛࢭ࣑໬ࡋࡸࡍ࠸ࡢ
࠿ࡣࢃ࠿ࡽ࡞࠸ࠋࡑࢀࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟ࡣỈᬗయࡢ⺮ⓑ㉁ࢆ༢㞳⢭〇ࡋࠊࡑࡢ⺮ⓑ㉁ࢆᵓᡂࡍࡿ࢔
࣑ࣀ㓟ࢆ 1 ṧᇶࡈ࡜࡟ࣛࢭ࣑໬ࡋ࡚࠸ࡿ࠿࡝࠺࠿ࢆ
ศᯒࡍ࡭ࡁ࡛࠶ࡿ࡜⪃࠼ࡓࠋ Ỉᬗయ⺮ⓑ㉁୰ࡢ '$VS ◊✲ࡢ㛤ጞ᫬㸸ᡂᯝࡢฟ࡞࠸  ᖺ㛫ヨᩱࡣධᡭࡋࡸࡍ࠸࣐࢘ࢫࡢ║ࢆ౑ࡗ࡚ᐇ㦂ࡍࡿࡇ࡜࡟ࡋࡓࠋ࣐࢘ࢫࡢỈᬗయࢆࡍࡾࡘࡪࡋ࡚ '$VSࡀᮏᙜ࡟⪁໬࡟ࡼࡗ࡚ቑ࠼࡚࠸ࡿ࠿࡝࠺࠿ࢆ☜࠿ࡵࡼ࠺࡜ࡋࡓࡀࠊ⤖ᯝࡣࢿ࢞ࢸ࢖ࣈ࡛࠶ࡗࡓࠋ࣐࢘ࢫ
ࡢᑑ࿨ࡀ▷࠸ࡇ࡜ࠊ㸯ࡘࡢỈᬗయ࠿ࡽᚓࡽࢀࡿࢧࣥ
ࣉࣝࡀᚤ㔞࡛࠶ࡿࡇ࡜ࡶᐇ㦂ࢆᅔ㞴࡟ࡋࡓࠋ኱ࡋࡓ
ᡂᯝࡶฟ࡞࠸ࡲࡲࠊ᭱ึࡢ  ᖺ㛫ࡢᮇ㝈ࡀษࢀࡓࠋ
ࡋ࠿ࡋࠊࡇࡢ  ᖺ㛫࡟⺮ⓑ㉁୰ࡢ '࢔࣑ࣀ㓟ࡢศᯒἲࢆ☜❧ࡉࡏࡓࡢ࡛ࠊ⺮ⓑ㉁ྵ㔞ࡢከ࠸࢘ࢩࡢỈᬗయࢆᮦᩱ࡜ࡋ࡚ᐇ㦂ࢆ⾜࠼ࡤࠊఱ࡜࠿ࢹ࣮ࢱࡀᚓࡽ
ࢀࡿࡣࡎ࡜⪃࠼ࠊ௵ᮇ௜࣏ࢫࢺࢆ⤊஢ᚋࠊ◊✲⏕࡜ࡋ࡚  ᖺ㛫ࡇࡢ◊✲ࢆ⥅⥆ࡍࡿࡇ࡜࡟ࡋࡓࠋ  '$VS ࡀᏑᅾࡍࡿ⺮ⓑ㉁ࢆ✺ࡁṆࡵࡿࠋ࢘ࢩࡢỈᬗయ࡟Ꮡᅾࡍࡿ」ᩘࡢ⺮ⓑ㉁࠿ࡽࠊ୍ࡘ
୍ࡘࡢ⺮ⓑ㉁࡟ศ㞳ࡋ࡚ࠊ⺮ⓑ㉁ࡈ࡜࡟࢔࣑ࣀ㓟ࡢ'ᆺ࡜ /ᆺࡢẚ⋡ࢆㄪ࡭ࡿ࡜࠸࠺ຊᴗ࡛ᆅ㐨࡞ᐇ㦂ࢆ⥆ࡅࡓࠋㄡࡶࡸࡗ࡚࠸࡞࠸ࡢ࡛ࠊཧ⪃࡜ࡍ࡭ࡁㄽ
ᩥࡶ࡞࠸ࠋฟཱྀࡀ࠶ࡿࡢ࠿࡝࠺࠿ࡶ୙᫂࡞ᡭ᥈ࡾ≧ែࡢᐇ㦂࡛࠶ࡗࡓࠋࡑࡋ࡚࢘ࢩࡢỈᬗయ࡛◊✲ࢆጞࡵ࡚࠿ࡽ⣙  ᖺᚋ࡟Ỉᬗయෆ࡟ '࢔࣑ࣀ㓟ࡀ⵳✚ࡉࢀ࡚࠸ࡿ࡜࠸࠺ࢹ࣮ࢱࡀᚓࡽࢀࡓࠋࡋ࠿ࡶ '࢔࣑ࣀ㓟ࡀ⵳✚ࡉࢀ࡚࠸ࡿ⺮ⓑ㉁ࢆ㏣㊧ࡋ࡚࠸ࡃ࡜ࠊࡑࢀ
ࡣỈᬗయෆࡢ୺せ࡞⺮ⓑ㉁࡛࠶ࡿ Įࢡࣜࢫࢱࣜࣥ
㸦&U\㸧࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡇࢀࡣ࠿࡞ࡾࠊ
ࣛࢵ࣮࢟࡞⤖ᯝ࡛࠶ࡗࡓࠋ&U\ ࡣỈ⁐ᛶ࡛ᢅ࠸ࡸࡍ
ࡃࠊ⺮ⓑ㉁㔞ࡶከࡃศᯒࡋࡸࡍ࠸⺮ⓑ㉁࡛࠶ࡾࠊ◊✲⵳✚ࡀ㇏ᐩ࡛࠶ࡿࠋࡕࡻ࠺࡝ࡑࡢࡇࢁࠊ⟃Ἴ኱Ꮫෆࡢࣉࣟࢪ࢙ࢡࢺ࡛  ᖺ㛫ࡢ௵ᮇ௜ࡁຓᡭࡢ࣏ࢫࢺ
ࢆᚓࡿࡇ࡜ࡀ࡛ࡁࡓࠋࡑࡇ࡛᭦࡟ᐇ㦂ࢆⓎᒎࡉࡏࡿࡓࡵ࡟ࠊࣄࢺࡢỈᬗయ୰ࡢ '࢔࣑ࣀ㓟ศᯒࢆィ⏬ࡋࡓࠋࣄࢺࡢヨᩱࡢධᡭࡣ኱ኚᅔ㞴࡛࠶ࡗࡓࡀࠊ▱ே
ࢆ㏻ࡌ࡚  ಶࡢỈᬗయࡢ౪୚ࢆཷࡅࡿࡇ࡜ࡀ࡛ࡁ
ࡓࠋࡑࢀࡲ࡛࡟࢘ࢩ࡛ '࢔࣑ࣀ㓟ࢆྵࡴ⺮ⓑ㉁ࡀ
Į&U\ ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚࠸ࡓࡢ࡛ࠊࣄࢺࡢ
Ỉᬗయ࡛ࡶ Į&U\ ࢆ୰ᚰ࡟ศᯒࢆ⾜ࡗࡓࠋࡑࡢ⤖ᯝࠊ$VS ࡢࣛࢭ࣑໬ࡣỈᬗయෆࡢ⺮ⓑ㉁࡛ࠊ୍ᵝ࡟㉳ࡇࡿࡢ࡛ࡣ࡞ࡃࠊỈᬗయࡢ୺ᡂศ࡛࠶ࡿ Į&U\ ࡢࢧࣈࣘࢽࢵࢺ࡛࠶ࡿ Į$ࠊĮ%&U\ ࡟≉␗ⓗ࡟⏕ࡌ࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ⟃Ἴ኱Ꮫ࡛ࡢ⣙  ᖺࡢᮇ㝈ࡀ⤊ࢃࡾ࡟㏆࡙࠸ࡓ㡭࡛࠶ࡿࠋ  &U\ ෆ࡛ࡢ '$VS ࡢ㒊఩ࢆ✺ࡁṆࡵࡿࠋ◊✲ࡢᮏ୸ࡣࠊࡇࢀ࠿ࡽ࡜࠸࠺࡜ࡁ࡟ࠊࡲࡓᮇ㝈ࡀࡸࡗ࡚ࡁ࡚⟃Ἴ኱Ꮫ࠿ࡽ㏥⫋ࢆ㏕ࡽࢀࡓࠋࡇࢀ࡛ࠊ
ࡇࡢ◊✲ࡶ⤊ࢃࡾࠊ୓஦❓ࡍ࡜ᛮࡗࡓ࡜ࡁࠊᙜ᫬ࠊ
⟃Ἴ࡟࠶ࡗࡓṊ⏣⸆ရᕤᴗ㸦ᰴ㸧ࡢ◊✲ᡤ࡛  ᖺ㛫ࡢዎ⣙♫ဨ࡜ࡋ࡚ࡇࡢ◊✲ࢆ⥅⥆ࡋ࡚ࡼ࠸࡜࠸࠺ヰࡀ࠶ࡾࠊ⛣ືࡋࡓࠋඛ➃ⓗ࡞ᶵჾࠊ㇏ᐩ࡞◊✲㈝ࠊ
࿘ᅖࡢඃ⚽࡞◊✲ဨ࡜ࡢウㄽ࡞࡝ࠊᜨࡲࢀࡓ⎔ቃୗ࡛௙஦ࡣ㣕㌍ⓗ࡟㐍ࡳࠊࣄࢺ Į&U\ ࡢࢧࣈࣘࢽࢵࢺ࡛࠶ࡿ Į$ࠊĮ%&U\ ୰ࡢ '$VS ṧᇶࡢ㒊఩ࢆ≉ᐃ࡛ࡁࡓࠋĮ$&U\ ࡛ࡣ  ␒┠ ࡜  ␒┠ࡢ $VS ࡀ>@ࠊ
Į%&U\ ࡛ࡣ  ␒┠࡜  ␒┠ࡢ $VS ࡀ≉␗ⓗ࡟ '㻙 㻢㻞㻌㻙

ᆺ࡟࡞ࡗ࡚࠾ࡾ>@ࠊ௚ࡢ㒊఩ࡢ $VS ࡣ 'ᆺ࡟࡞ࡗ࡚
࠸࡞࠸࡜࠸࠺ࡇ࡜ࡀࢃ࠿ࡗࡓࠋ≉࡟  ṓࡢࣄࢺࡢ
Į$&U\ ୰ࡢ  ␒┠ ࡜  ␒┠ࡢ $VS ࡛ࡣࠊ㏻ᖖࡣ
/ᆺࡢ᪉ࡀᅽಽⓗ࡟ከ࠸⏕యෆ࡟࠾࠸࡚ࠊ㏫࡟ 'ᆺࡢ᪉ࡀ / ᆺࡼࡾᩘಸࡶከࡃ༢⣧࡞ࣛࢭ࣑໬཯ᛂ࡛ࡣ࡞࠸཯㌿཯ᛂ࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡗࡓ>@ࠋࡇࡢ࡜ࡁࡢ
㌟ࡀ㟈࠼ࡿࡼ࠺࡞⯆ዧࡣ௒࡛ࡶᛀࢀࡽࢀ࡞࠸ࠋ
ྠ᫬࡟ఱ࠿ࡢ㛫㐪࠸࡛ࡣ࡞࠸࠿࡜ఱᗘࡶᐇ㦂ࢆ⧞ࡾ㏉ࡋࠊ㈗㔜࡞ࢧࣥࣉࣝࢆ↓㥏㐵࠸ࡋ࡚ᚋ᜼ࡋࡓ࡯࡝
࡛࠶ࡿࠋḟ࠸࡛ࠊࡇࡢ⏬ᮇⓗ࡞ᡂᯝࢆ㇏ᐩ࡞ࢹ࣮ࢱ
࡜࡜ࡶ࡟ㄽᩥ࡟ࡋࠊ⮬ศ࡜ࡋ࡚ࡣ┦ᙜ࡞⮬ಙࢆࡶࡗ࡚ࠊ⏕໬Ꮫࡢศ㔝࡛ᶒጾࡢ࠶ࡿ - %LRO &KHP࡟ᢞ✏ࡋࡓࡀࠊࡇࡢ -RXUQDO ࡟ࡣྜ⮴ࡋ࡚࠸࡞࠸࡜࠸࠺ࢃࡅ
ࡢࢃ࠿ࡽ࡞࠸⌮⏤࡛ UHMHFW ࡉࢀࡓࠋ⤖ᒁࠊูࡢㄽᩥ
࡟ᢞ✏ࡋ SXEOLVK ࡉࢀࡓࡀࠊ⏕యෆࡢࡼ࠺࡞✜ࡸ࠿࡞⎔ቃ࡛ࠊ࢔࣑ࣀ㓟ࡀຍ㱋࡟క࠸ᚎࠎ࡟ /ᆺ࠿ࡽ 'ᆺ࡟ኚ໬ࡍࡿ࡜࠸࠺⤖ᯝࡣࠊ㒊఩ࢆỴᐃࡋࠊ⢭ᐦ࡞ᐇ㦂ࢆ✚ࡳ㔜ࡡ࡚ࡶᖖ㆑࡟⦡ࡽࢀࡓ⏕໬Ꮫ⪅ࡢ⌮ゎࡣᚓࡽࢀ࡞࠿ࡗࡓࡢࡔࢁ࠺࡜ᛮࢃࢀࡓࠋ
 ⺮ⓑ㉁୰࡛ࡢ '$VS ⏕ᡂࡢᶵᵓࢆ✺ࡁṆࡵࡿ◊✲㛤ጞᚋ  ᖺ࡛ࠊ࡜࡟࠿ࡃࠊ&U\ ୰࡛ 'య໬ࡋ࡚࠸ࡿ࢔࣑ࣀ㓟ࢆ≉ᐃ࡛ࡁࡓࠋḟࡢẁ㝵࡜ࡋ࡚ࡣ࡞
ࡐࠊྠࡌ $VS ࡞ࡢ࡟ࠊ'య໬ࡀ⏕ࡌ࡚࠸ࡿ࡜ࡇࢁ࡜
ࡑ࠺࡛࡞࠸࡜ࡇࢁࡀ࠶ࡿࡢ࠿㸽࡜࠸࠺࡜ࡇࢁࢆ✺ࡁṆࡵࡓ࠸ࠋࡋ࠿ࡋࠊṊ⏣⸆ရ࡜ࡢዎ⣙ࡣࡇࡇ࡛⤊஢ࠋḟࡢᑵ⫋ඛࡢ࠶࡚ࡶ࡞ࡃࠊ࠸ࡼ࠸ࡼࠊࡇࢀ࡛⤊ࢃࡾ࠿࡜࠶ࡁࡽࡵ࠿ࡅࡓ࡜ࡁࠊே⏕᭱኱⣭ࡢᖾ㐠ࡀ⯙࠸㎸ࢇࡔࠋ⛉Ꮫᢏ⾡᣺⯆஦ᴗᅋ㸦-67㸧ࡢࠕࡉࡁࡀࡅ◊✲ ࠖࡢࠕሙ࡜཯ᛂࠖ㡿ᇦࡢ◊✲⪅࡟  ᖺ㛫᥇⏝ࡉࢀࡓࡢ࡛࠶ࡿࠋ-67 ࡣఱࡢᚋࢁ┪ࡶ࡞࠸↓ྡ◊✲⪅ࡢࠕ⺮ⓑ㉁୰࡛ࡢ $VS ṧᇶࡢ཯㌿ᶵᵓࢆゎ᫂ࡍࡿࠖ࡜࠸࠺ᥦ᱌ࢆ᥇ᢥࡋ࡚ࡃࢀࡓࡢ࡛࠶ࡿࠋ༑ศ࡞◊✲㈝࡜ᨭ᥼ࠊᖺ࡟ᩘᅇࡢ่⃭ⓗ࡞ሗ࿌఍ࡀ◊✲ࢆ㐍ࡵࡿୖ࡛኱࠸࡟ᙺ❧ࡗࡓࠋࡑࡋ࡚  ᖺᚋ࡟ࡣ⺮ⓑ㉁୰
࡛ࡢ $VS ṧᇶࡢ཯㌿ᶵᵓࢆゎ࡛᫂ࡁࡓࠋࡍ࡞ࢃࡕࠊ
ࡇࢀࡣ $VS ṧᇶ࡟≉␗ⓗ࡟⏕ࡌࡿ཯ᛂ࡛࠶ࡗࡓࡢ࡛
࠶ࡿࠋ㏻ᖖ࢔࣑ࣀ㓟ࡀ⏕యෆ࡛ 'య໬ࡍࡿ࡟ࡣ Į Ⅳ⣲࡟⤖ྜࡋ࡚࠸ࡿ + ࡀᘬࡁᢤ࠿ࢀ࡞ࡃ࡚ࡣ࡞ࡽ࡞࠸
ࡀࠊ⏕యෆࡢࡼ࠺࡞ ᗘ࡛ࡣࡇࡢ཯ᛂࡣ㉳ࡇࡽ࡞࠸ࠋ
ࡋ࠿ࡋࠊ$VS ࡣ௚ࡢ࢔࣑ࣀ㓟࡜ࡣ␗࡞ࡾࠊഃ㙐࡟࢝ࣝ࣎࢟ࢩࣝᇶࢆ᭷ࡍࡿࡓࡵ࡟  ဨ⎔࢖࣑ࢻࢆᙧᡂࡍ
ࡿࠋࡇࡢ࢖࣑ࢻయ࠿ࡽࡣ + ࡀᐜ᫆࡟ᘬࡁᢤ࠿ࢀࡿࡢ
2

2
+&
1
+

&

&
+
&

2

2+
+
1
2

2

&
+& + 1

2

1+

1
+

&

&
+
&
2

>ɴͲƐƉ

1
+
2+

+&

+ &

1

&

&

&

1+

>ɲͲƐƉ

&

+&

+

&

1
+
2

2+
+

&
2

>ͲƐƵĐĐŝŶŝŵŝĚĞ

+1

&

2+
+
1

2

ɲͲƐƉ

&+ & + 1

&

&
+

&
2

2

ͲƐƵĐĐŝŶŝŵŝĚĞ
+ &
1
+

ᅗϮ⺮ⓑ㉁୰䛾ƐƉṧᇶ䛾␗ᛶ໬ᶵᵓ

&

&
+
&

1
+
2+

2

ɴͲƐƉ

࡛ࡇࡇ࡛ࠊ/ య࠿ࡽ ' య࡬࡜཯㌿ࡍࡿࠋ୧࢖࣑ࢻయ
࠿ࡽᐜ᫆࡟ 'ȕ'Į/ȕ య࡬࡜␗ᛶ໬ࡋࠊ ✀㢮ࡢ␗ᛶయࡀ⏕ࡌࡿ ᅗ  ࠋᮏ཯ᛂࡣ $VS ṧᇶࡢ㞄᥋ṧᇶࡀᑠࡉ࠸࢔࣑ࣀ㓟ࡢ᫬ 㸦*O\ 6HU $OD ࡞࡝㸧ࠊ࠾ࡼ
ࡧ $VS ṧᇶࡀ⺮ⓑ㉁ࡢ⾲㠃࡟఩⨨ࡋ࡚࠸ࡿ࡜ࡁ࡟⏕ࡌࡸࡍ࠸࡜࠸࠺ࡇ࡜ࡀศ࠿ࡗࡓ>@ࠋ  ⺮ⓑ㉁⛉Ꮫ࡟࠾ࡅࡿ '࢔࣑ࣀ㓟Ꮫࡢ๰⏕ࠕࡉࡁࡀࡅ◊✲ ࠖ⤊஢ᚋࡶ㊰㢌࡟㏞࠸ࡑ࠺࡛࠶ࡗ
ࡓࡀࠊ㐠Ⰻࡃி㒔኱ᏛཎᏊ⅔ᐇ㦂ᡤࡢຓᩍᤵබເ࡟
ᛂ⏝ࡋ᥇⏝ࡉࢀࡓࠋᏛ఩ྲྀᚓᚋ  ᖺ┠࡟ࡋ࡚ึࡵ࡚
ࡢࣃ࣮࣐ࢿࣥࢺ࣏ࢫࢺ࡛ࠊࡇࢇ࡞࡟Ꮀࡋ࠸ࡇ࡜ࡣ࡞
ࡃࠊᙜ᫬ࡢே஦㑅⪃ጤဨࡸ㉥ᫍᩍᤵ࡟ᚰࡼࡾឤㅰࡋ
࡚࠸ࡿࠋ⮬ศࡢ◊✲ࡀࡇࡢඛࠊᐃᖺࡲ࡛⥅⥆࡛ࡁࡿ࡜࠸࠺ᖾ⚟ឤࢆࡋࡳࡌࡳ࡜ឤࡌࡓࠋࡑࡢᚋࠊᩍᤵ࡜
ࡋ࡚ࠊ⌧ᅾࡲ࡛࡟ࢫࢱࢵࣇࡸከࡃࡢᏛ⏕ࠊᡤෆእࡢ
ඹྠ◊✲⪅࡞࡝ከࡃࡢேࠎࡢᨭ᥼࡜༠ຊ࡟ࡼࡗ࡚㏵
ษࢀࡿࡇ࡜࡞ࡃࡇࡢ◊✲ࢆ⥆ࡅࡿࡇ࡜ࡀ࡛ࡁࡓࠋ⌧ᅾࡣࠊⓑෆ㞀ࠊຍ㱋ᛶ㯤ᩬኚᛶ⑕ࠊ⓶⭵◳໬ࠊ࢔ࣝࢶࣁ࢖࣐࣮⑓ࡢࡼ࠺࡞⺮ⓑ㉁ࡢࣇ࢛࣮ࣝࢹ࢖ࣥࢢ␗
ᖖࢆక࠺ຍ㱋ᛶ⑌ᝈࡣ '$VS ࡢ⏕ᡂࡀࡁࡗ࠿ࡅ࡛⺮࡛࠶ࡗ࡚ࡶࡼ࠸ࠋ⺮ⓑ㉁ࡢΰྜ≀ࢆࢺࣜࣉࢩࣥ࡜࠸
࠺㓝⣲࡛ษ᩿ࡋࠊᚓࡽࢀࡓ࣌ࣉࢳࢻ᩿∦ࢆ /&06 ࡟ᑟධࡍࡿࠋ࣌ࣉࢳࢻࡢྠᐃࡣ /&06 ࡟௜ᒓࡍࡿ
0606 ศᯒ࡟ࡼࡗ࡚⾜࠸ࠊࢹ࣮ࢱ࣮࣋ࢫ࡜↷ྜࡍࡿࡇ࡜࡟ࡼࡗ࡚⡆༢࡟⾜࠼ࡿࠋ$VS ṧᇶࡣᅗ  ࡛♧ࡋࡓࡼ࠺࡟  ࡘࡢ␗ᛶయࡀᏑᅾࡍࡿࠋࡇࢀࡽ  ࡘࡢ␗ᛶయࢆྵࡴ࣌ࣉࢳࢻࡣ㉁㔞ࡀྠ୍࡛࠶ࡿࡀࠊᅗ  ࡟♧ࡍࡼ࠺࡟㏫┦ࢡ࣐ࣟࢺࢢࣛࣇࢆ⏝࠸ࡓᾮయࢡ࣐ࣟ
ࢺࢢࣛࣇ /& ୖ࡛  ࡘࡢࣆ࣮ࢡ࡟ศ㞳ࡍࡿࠋࡘࡲࡾࠊ㉁㔞ࡀྠ୍࡛」ᩘࡢࣆ࣮ࢡ࡟ศ㞳ࡋ࡚࠸ࡿࡢࡀ␗ᛶ
యࢆྵࡴ࣌ࣉࢳࢻ࡛࠶ࡿ࡜ุᐃ࡛ࡁࡓࠋ࡝ࡢࣆ࣮ࢡ
ࡀ࡝ࡢ $VS ␗ᛶయ࣌ࣉࢳࢻ࡟ヱᙜࡍࡿࡢ࠿ࡣ  ࡘࡢ␗ᛶయ࣌ࣉࢳࢻࢆྜᡂࡋࠊ/& ୖ࡛ࡢ⁐ฟ᫬㛫ࡢẚ㍑ࠊ

ᅗ  /&0606 ࡟ࡼࡿ⺮ⓑ㉁୰ࡢ $VS ␗ᛶయศᯒᅗ  ✀ࠎࡢ⪁໬⤌⧊ࡢ '࢔࣑ࣀ㓟ྵ᭷
⺮ⓑ㉁ ㉥ࠊࡲࡓࡣ㉥〓Ⰽ ⓑ㉁ࡀ␗ᖖจ㞟໬ࡋࠊⓎ⑕ࡋࡓࡶࡢ࡜⪃࠼࡚◊✲ࢆ⾜ࡗ࡚࠸ࡿࠋ'$VS ྵ㔞ࡀከ࠸⺮ⓑ㉁ࡣ୙⁐໬ࡋᶵ⬟ࡀపୗࡋ࡚࠸ࡿࡇ࡜࡞࡝ࡀ᫂ࡽ࠿࡟࡞ࡗࡓ>@ࠋࡲࡓࠊ⣸እ⥺>@ࡸᨺᑕ⥺↷ᑕ>@࡛ࡇࡢ཯ᛂࡀಁ㐍ࡍࡿࡇ࡜ࡶ᫂ࡽ࠿࡜࡞ࡗࡓࠋ
ࡉࡽ࡟ࠊ⺮ⓑ㉁୰࡛ࡢ $VS ࡢ␗ᛶ໬㏿ᗘࡣᙜึண
ࡋ࡚࠸ࡓࡼࡾࡶ㏿ࡃࠊᩘᖺ௨ෆ࡟ᩘ༑㸣ࡶ␗ᛶ໬ࡍࡿ㒊఩ࡶ࠶ࡿࡇ࡜࡞࡝ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ>@ࠋࡇࢀࡽࡢ⤖ᯝࡣ⏕యෆ࡛ࡢ $VS ࡢ␗ᛶ໬཯ᛂࡣỈᬗయ࡟㝈ࡽࡎࠊ࠶ࡽࡺࡿ࡜ࡇࢁ࡛⏕ࡌ࡚࠸ࡿྍ⬟ᛶࡶ♧၀ࡋ࡚࠸ࡓࠋ௒ࡲ࡛ሗ࿌౛ࡀ࡞࠿ࡗࡓࡢࡣࠊࡑࡶࡑࡶ
ࠕ'࢔࣑ࣀ㓟ࡣ⏕యෆ࡟ࡣᏑᅾࡋ࡞࠸ࠖ࡜࠸࠺ᛮ࠸
㎸ࡳࡀ࠶ࡗࡓ࡜࠸࠺ࡇ࡜࡟ຍ࠼࡚ࠊ⤖ྜᆺ '࢔࣑ࣀ㓟ศᯒࡣ↹㞧࡛ࠊศᯒࡋ࡟ࡃ࠸࡜࠸࠺ḞⅬࡀ࠶ࡾࠊ␗ศ㔝◊✲⪅ࡀཧධࡋ࡟ࡃ࠿ࡗࡓࡓࡵ࡜⪃࠼ࡽࢀࡓࠋ
ࡑࡇ࡛ࠊ➹⪅ࡽࡣࠊᾮయࢡ࣐ࣟࢺࢢࣛࣇ㉁㔞ศᯒ⿦⨨㸦/&06㸧ࢆ⏝࠸ࡓ᪂ࡓ࡞ศᯒᡭẁ࡛⺮ⓑ㉁୰ࡢ
$VS ṧᇶࡢ␗ᛶయ㒊఩ࢆྠᐃࡍࡿ᪉ἲࢆ⪃᱌ࡋࠊᚑ᮶ἲࡼࡾࡶ኱ᖜ࡟ヨᩱࡢᚲせ㔞ࢆᑡ࡞ࡃࡋࠊศᯒ᫬
㛫ࡶ▷⦰ࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓ>@ࠋࡑࡢ᪉ἲࢆ⡆༢
࡟㏙࡭ࡿࠋ⺮ⓑ㉁ࡣ༢㞳⢭〇ࡍࡿᚲせࡣ࡞ࡃΰྜ≀㻙 㻢㻟㻌㻙

ᅗ 5  ṓⓑෆ㞀ᝈ⪅ࡢỈᬗయࡢྍ⁐ᛶ㸦:6㸧⏬ศ ୙⁐ᛶ㸦:,㸧⏬ศ୰ࡢ Į$Į%ࢡࣜࢫࢱࣜࣥ୰ࡢ
$VS ␗ᛶయࡢ㒊఩࡜ࡑࡢ┦ᑐ㔞ࡲࡓࡣᅗ  ࡟♧ࡍࡼ࠺࡟ࡑࢀࡒࢀࡢ $VS ␗ᛶయࢆ≉␗ⓗ࡟ㄆ㆑ࡍࡿ㓝⣲ࢆ⏝࠸ࡿࡇ࡜࡟ࡼࡗ࡚ศᯒ࡛ࡁ
ࡓ>@ࠋࡑࡢࡼ࠺࡞᪉ἲࢆ⏝࠸࡚ᚓࡓ⤖ᯝࢆᅗ  ࡟♧ࡋࡓࠋᅗ  ࡛♧ࡍࡼ࠺࡟ Į$ࢡࣜࢫࢱࣜࣥ୰࡛ࡣ
$VS ࡀ Į%ࢡࣜࢫࢱࣜࣥ୰࡛ࡣ $VS ࡀⴭࡋࡃ␗ᛶ໬ࡋ࡚࠸ࡓࠋࡇࢀࡣᚑ᮶ἲ࡛ᚓࡓ⤖ᯝ࡜୍⮴ࡋࡓࠋ᪂ศᯒἲ࡛ࡣࡇࢀࡽࡢṧᇶ࡟ຍ࠼࡚ Į$ࢡࣜࢫࢱࣜࣥ୰ࡢ $VS Į%ࢡࣜࢫࢱࣜࣥ୰ࡢ $VSࡢ␗ᛶ໬㒊఩ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋࡉࡽ࡟ࠊ࠸࡙ࢀࡢ
ṧᇶ࡟࠾࠸࡚ࡶ :, ⏬ศ୰ࡢࢡࣜࢫࢱࣜࣥࡢ᪉ࡀࠊ
:6 ⏬ศࡢࢡࣜࢫࢱࣜࣥࡼࡾࡶ␗ᛶ໬⋡ࡀ㧗࠿ࡗࡓࠋࡇࡢ⤖ᯝࡣ $VS ࡢ␗ᛶ໬ࡀ &U\ ࡢ୙⁐໬ࡸจ㞟ࢆᘬࡁ㉳ࡇࡋࡓࡇ࡜ࢆᙉࡃ♧၀ࡋ࡚࠸ࡿࠋࡲࡓࠊ␗ᛶయ
ࡢ୰࡛ࡣ 'ȕయࡀከࡃᏑᅾࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ
ࡓࠋࡇࢀࡣ 'ȕయࡀ໬Ꮫⓗ࡟Ᏻᐃ࡛࠶ࡿࡓࡵࡔ࠿ࡽ
࡜࠸࠺ࡇ࡜ࡶࢃ࠿ࡗࡓ>@ࠋ୍ࡘࡢศ㔝ࡢ◊✲ࡢ㐍ᒎࡣศᯒἲࡢ㐍ᒎ࡟౫Ꮡࡍ
ࡿࡇ࡜ࡀከ࠸ࠋ㏆ᖺࠊ➹⪅ࡽࡢࢢ࣮ࣝࣉ௨እ࠿ࡽࡶ
㉁㔞ศᯒࢆ฼⏝ࡋࡓ '࢔࣑ࣀ㓟ศᯒࡢሗ࿌ᩘࡀ኱ᖜ
࡟ቑ࠼࡚࠸ࡿࠋࡶࡣࡸࠊຍ㱋⤌⧊࡟࠾ࡅࡿ '࢔࣑ࣀ㓟ྵ᭷⺮ⓑ㉁ࡢ⵳✚ࡣᖖ㆑࡜࡞ࡗࡓࠋᙜヱศ㔝ࡢ◊✲⪅ேཱྀࡣⴭࡋࡃቑຍࡋ࡚࠸ࡿࡇ࡜࠿ࡽࠊ௒ᚋࠊ✀ࠎࡢ⤌⧊࠿ࡽࡢ '࢔࣑ࣀ㓟ྵ᭷⺮ⓑ㉁ࡢሗ࿌ࡀቑ࠼ࡿ
ࡇ࡜ࡀᮇᚅ࡛ࡁࡿࠋ
ḟẁ㝵࡜ࡋ࡚ࠊ௦ㅰࠊ㜵ᚚᶵᵓࡢゎ᫂ࡀᚲ㡲࡛࠶ࡿࠋయෆ࡛⵳✚ࡋ࡚࠸ࡿ '࢔࣑ࣀ㓟ྵ᭷⺮ⓑ㉁ࡣ /࢔࣑ࣀ㓟࣏࣐࣮࡛ࣜ࠶ࡿ㓝⣲࡟ࡣศゎࡉࢀ࡞࠸ࡣࡎ
࡛࠶ࡿࠋᚑࡗ࡚ࠊ'࢔࣑ࣀ㓟ྵ᭷⺮ⓑ㉁ࡣ඲ࡃ௦ㅰ
ࡉࢀࡎ࡟⤌⧊ෆ࡟⵳✚ࡉࢀ࡚࠸ࡿࡢ࠿ࠊ࠶ࡿ࠸ࡣ୍
㒊௦ㅰࡉࢀ࡚ࠊ࣌ࣉࢳࢻ࡜ࡋ࡚Ꮡᅾࡍࡿࡢ࠿ࠊ୙᫂
Ⅼࡀከ࠸ࠋ᭱㏆ࠊ➹⪅ࡽࡣ '࢔࣑ࣀ㓟ྵ᭷࣌ࣉࢳࢻ
ࢆ⾑୰᳨࡛ฟࡋࡓࠋࡇࢀࡣ࠶ࡿ⺮ⓑ㉁ࡢ୍㒊ศࡢ㓄ิࢆ᭷ࡋ࡚࠸ࡓࠋࡘࡲࡾࠊࡇࡢ࣌ࣉࢳࢻࡣ '࢔࣑ࣀ㓟ࡀྵࡲࢀࡿࡓࡵ࡟ࡑࢀ௨ୖ௦ㅰࡉࢀࡎ࡟⾑୰࡟Ꮡᅾࡋ࡚࠸ࡓࡶࡢ࡜⪃࠼ࡽࢀࡓࠋ'࢔࣑ࣀ㓟ྵ᭷⺮ⓑ㉁ࡢ௦ㅰ◊✲࡞࡝ࡶ㜵ᚚᶵᵓ࡜ྜࢃࡏ࡚ḟࡢୡ௦ࡢ⯆࿡῝࠸◊✲ᑐ㇟࡜࡞ࡿ࡜ᛮࢃࢀࡿࠋ
ᮏ◊✲࡟ࡼࡾ㐍໬ࡢ㐣⛬࡛⋓ᚓࡋࡓ⺮ⓑ㉁ࡢ /࢔࣑ࣀ㓟࣍ࣔ࢟ࣛࣜࢸ࢕࣮ࡣ୍ಶయࡢ⪁໬ࡢ㐣⛬࡛◚ࡓࢇࡋ࡚࠸ࡿࡇ࡜ࡀ᫂☜࡟࡞ࡗࡓࠋ௒ᚋࡢ⏕࿨⛉Ꮫ࡟࠾࠸࡚ࡣࠊ'࢔࣑ࣀ㓟࡜࠸࠺ࡶ࠺୍᪉ࡢ࢟ࣛࣜࢸ
࢕࣮ࡶ⪃៖ࡋࡓࣃࣛ࢟ࣛࣜࢸ࢕࣮ࡢᴫᛕࢆᑟධࡍࡿ
ࡇ࡜ࡀ⏕࿨άືࠊ೺ᗣࠊ⪁໬࡟ࡘ࠸࡚ࠊࡼࡾ῝࠸Ὕᐹࢆྍ⬟࡟ࡍࡿ࡜ᛮࢃࢀࡿࠋᚑ᮶ࡢ /࢔࣑ࣀ㓟࡜࠸࠺୍᪉ࡢ࢟ࣛࣜࢸ࢕࣮ࡔࡅࡢୡ⏺ほ࡛ࡣ͆∦ᡭⴠࡕ͇࡛ࠊゎỴ࡛ࡁ࡞࠿ࡗࡓࡇ࡜ࡀ '࢔࣑ࣀ㓟ࢆ⪃៖ࡍࡿࡇ࡜࡟ࡼࡾၥ㢟ゎỴࡀᅗࢀࡿྍ⬟ᛶࡀ࠶ࡿ࠿ࡽ࡛࠶
ࡿࠋ'࢔࣑ࣀ㓟◊✲ࡣ⏕࿨ࢆᵓᡂࡍࡿศᏊࡢ∦ᡭᵓ㐀ᶞ❧ࡢㅦ࡟ࡶ㏕ࡿព⩏῝࠸◊✲࡛࠶ࡿࠋࣃࣛ࢟ࣛ
ࣜࢸ࢕࣮ࡢᴫᛕࡣ⏕࿨⛉Ꮫ࡟࠾ࡅࡿࣃࣛࢲ࢖࣒࡜⪃࠼ࡽࢀࡿࠋ'࢔࣑ࣀ㓟ࢆᣦᶆ࡟⏕࿨άືࠊຍ㱋ࡸ⑓ែࢆ⌮ゎࡍࡿࠋࡑࡢᛂ⏝࡜ࡋ࡚⑌ᝈࡢண▱࣭ண㜵ἲࢆ㛤Ⓨࡋࠊ㧗㱋໬♫఍࡟࠾ࡅࡿ೺ᗣᑑ࿨ࡢఙ㛗࡟㈉⊩ࡋࡓ࠸࡜⪃࠼࡚࠸ࡿࠋ
ㅰ㎡
ᮏ◊✲ࡣከࡃࡢேࠎࡢࡈ༠ຊࠊࡈᨭ᥼࡜ᖾ㐠࡟ᜨࡲࢀࠊ㐍ᒎࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡲࡋࡓࠋ⟃Ἴ኱ᏛࠊṊ⏣⸆ရᕤᴗᰴᘧ఍♫ࠊࡉࡁࡀࡅ◊✲ ࠊཎᏊ⅔ᐇ㦂ᡤࡢⓙᵝࠊ◊✲ᐊࡢࢫࢱࢵࣇࠊᏛ⏕ࡢⓙᵝࠊඹྠ◊✲⪅ࡢⓙᵝ᪉࡟ᚰࡼࡾឤㅰ⏦ࡋୖࡆࡲࡍࠋ

࠾ࢃࡾ࡟'࢔࣑ࣀ㓟ࡣ⺮ⓑ㉁୰ࡔࡅ࡛ࡣ࡞ࡃ࡚ࠊ㐟㞳ᆺ࡛ࡶᏑᅾࡍࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࠋ㐟㞳ᆺࡢ '࢔࣑ࣀ㓟ࡣ⚄⤒ᅇ㊰⥙ࡢάືㄪ⠇ࠊ࣍ࣝࣔࣥࡢྜᡂࠊศἪ
ࡢㄪ⠇࡞࡝ࢆ⾜ࡗ࡚࠸ࡿࠋ࣌ࣉࢳࢻ୰࡛ࡣ '࢔࣑ࣀ㓟ࡀࡑࡢ⏕⌮άᛶ࡟ᚲ㡲࡛࠶ࡿ࣌ࣉࢳࢻࡀⓎぢࡉࢀ࡚࠸ࡿࠋ'࢔࣑ࣀ㓟ࡣࡶࡣࡸࠊ㠀ኳ↛ᆺࡢ࢔࣑ࣀ㓟࡜ࡣ࠸࠼࡞࠸ࠋࡇ࠺ࡋࡓ⫼ᬒࡢࡶ࡜ࠊ➹⪅ࡣ  ᖺ࡟ከࡃࡢ◊✲⪅௰㛫࡜࡜ࡶ࡟ '࢔࣑ࣀ㓟◊✲఍ ⌧'࢔࣑ࣀ㓟Ꮫ఍ ࢆ❧ࡕୖࡆࡓࠋ௨᮶ࠊᮏᏛ఍ࡣ௒᪥
࡟⮳ࡿࡲ࡛ẖᖺࠊᏛ఍ࢆ㛤ദࡋࠊ໬ᏛࠊᕤᏛࠊ㎰Ꮫࠊ་⸆ࠊ㣗ရ໬Ꮫࠊ㓝⣲Ꮫࠊ⣽⬊⏕≀Ꮫ࡞࡝ࠊከᵝ࡞ศ㔝ࡢ◊✲⪅ࡀཧຍࡋ┒ἣࢆᴟࡵ࡚࠸ࡿࠋ ᖺ࡟
ࡣ '࢔࣑ࣀ㓟ᅜ㝿఍㆟ࡶ୺ദࡋࡓࠋࡑࡢᚋࠊᅜ㝿఍㆟ࡶᩘᖺࡈ࡜࡟㛤ദࡋࠊᮏศ㔝ࡣ኱࠸࡞ࡿὀ┠ࢆ㞟ࡵࡿࡼ࠺࡟࡞ࡗࡓࠋࡑࡢ㛫࡟ከࡃࡢேࠎ࡜ '࢔࣑ࣀ㓟㛵㐃ࡢᮏࡶฟ∧ࡋࡓ>@ࠋ⏕໬Ꮫࡢ୰࡛ '࢔࣑ࣀ㓟ࡀᏛၥศ㔝࡜ࡋ࡚ㄆࡵࡽࢀࡿࡼ࠺࡟࡞ࡾࠊᅜ㝿ⓗ࡟ࡶ᪂ࡓ࡞Ꮫၥࡢ₻ὶ࡜࡞ࡾࡘࡘ࠶ࡿࠋ ᖺ๓࡜ẚ࡭ࡿ࡜㝸ୡࡢឤࡀ࠶ࡿࠋཧ⪃ᩥ⊩>@ 1)XMLL et al., -%LRFKHP   
>@ 1 )XMLL et al., %LRFKLP %LRSK\V $FWD 
  
>@ 1)XMLL et al.,%LRSK\V%LRFKHP5HV&RPPXQ
  >@ 1)XMLL et al $PLQR$FLGV >@ <0RULet al-&KURPDWRJU% >@ 1 )XMLL et al %LRFKHP %LRSK\V 5HV &RPP
 >@ 1 )XMLL et al 3KRWRFKHP 3KRWRELRO  
>@ . $NL et al 3/R6 2QH    H
GRLMRXUQDOSRQH
>@ 1 )XMLL et al., - %LRO &KHP  
 
>@ +0DHGD et al. $QDO&KHP  >@ (GV + %UXFNQHU DQG 1 )XMLL ³'$PLQR $FLGV LQ&KHPLVWU\/LIH6FLHQFHVDQG%LRWHFKQROJ\³ :LOH\9&+ =XULFK6ZLW]HUODQG)XQGDPHQWDO DJLQJUHVHDUFK XVLQJDSURWHLQERXQG'DPLQRDFLG 7KHLPSRUWDQFHRIWKHLGHDRI³3DUDFKLUDOLW\´LQ/DPLQRDFLGZRUOG 1RULNR)XMLLQIXMLL#UULN\RWRXDFMS㻙 㻢㻠㻌㻙

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࡟ཎᏊ⅔ᐇ㦂ᡤ࡟࠾ࡅࡿඹྠ฼⏝࣭ඹྠ◊✲ᡂᯝࡢ୍㒊ࢆࠊᡤဨࠊᡤእࡢඹྠ฼⏝◊✲⪅ࡣࡶࡕࢁࢇࠊ୍⯡ࡢ᪉ࠎ࡟࠾▱ࡽࡏࡍࡿࡇ࡜ࡀ㛤ദࡢ㊃᪨࡛ࡍࠋ➨㸳 ᅇி㒔኱Ꮫཎ
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᪂ேㅮ₇

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ࣉࣟࢪ࢙ࢡࢺ◊✲ᡂᯝሗ࿌

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