生化学講座細胞情報科学分野
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主な論文・著作・業績①Ishisaki, A.et al.(1st in 9 authors): Diﬀerential Inhibition of Smad6 and Smad7 onbone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B
cells./J. Biol. Chem., 274: 13637-13642, (1999)②Ishisaki, A.et al.(1st in 4 authors): Human umbilical vein endothelium-derived cells
retain potential to differentiate into smooth muscle-like cells./J. Biol. Chem., 278: 13031309, (2003)③Kanno, Y.et al.(2nd in 12 authors): Plasminogen/Plasmin modulates bone metabolism

石崎明

生化学講座細胞情報科学分野

常態系口腔科学関連、 by regulating the osteoblast and osteoclast function./J. Biol. Chem., 286: 8952-8960,

教授

博⼠（⻭学） 病態系口腔科学関連、 (2011)
腫瘍生物学関連④Kanno, Y.et al.(4th in 4 authors):uPA-derived peptide, A6 is involved in thesuppression of lipopolysaccaride-promoted inflammatory osteoclastogenesis and theresultant bone loss./Immun. Inflamm. Dis., doi:10.1002/iid3.169,(2017)⑤Takizawa, N.et al. (12th in 13 authors): Bone marrow-derived mesenchymal stem
cells propagate immunosuppressive/anti-inflammatory macrophages in cell-to-cell
contact-independent and -dependent manners under hypoxic culture./ Exp. Cell Res.,
doi:10.1016/j.yexcr.2017.07.014,(2017)

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主な論文・著作・業績①Hirano T., et al.(last in 5 authors/Corresponding author): TGF-β1 induces N-cadherin
expression by upregulating Sox9 expression and promoting its nuclear translocation inhuman oral squamous cell carcinoma cells./ Oncol Lett. 20:474-482(2020)②Hino M., et al. (2nd in 7 authors/Corresponding author): Transforming growth factorβ1 induces invasion ability of HSC-4 human oral squamous cell carcinoma cells
through the Slug/Wnt-5b/MMP-10 signalling axis./ J. Biochem.159:631–640(2016)③Saito, D., et al. (last in 9 authors/Corresponding author): Transforming growth factor-

加茂政晴

生化学講座細胞情報科学分野

常態系口腔科学関連、准教授

博⼠（理学） 病態系口腔科学関連、
腫瘍生物学関連

β1 induces epithelial-mesenchymal transition and integrin α3β1-mediated cell
migration of HSC-4 human squamous cell carcinoma cells through Slug./ J. Biochem.
153:303–315(2013)④Kamo, M. and Tsugita, A.: Speciﬁc cleavage of amino side chains of serine/threonine
in peptides and proteins with S-ethyl trifluorothioacetate vapor./ Eur. J. Biochem.
255:162-171(1998)⑤Kamo, M., et al.(1st in 4 authors): Separation and Characterization of Arabidopsis
thathiana proteins by two-dimensional gel electrophoresis./ Electrophoresis 16:423430(1995)

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主な論文・著作・業績①Inoue M., Yamada J, Aomatsu-Kikuchi E., Satoh K., Kondo H., Ishisaki A., Chosa N.
"SCRG1 suppresses LPS-induced CCL22 production through ERK1/2 activation inmouse macrophage Raw264.7 cells". Molecular Medicine Reports, 15:4069-4076, 2017.
②Suzuki K.*, Chosa N.*, Sawada S., Takizawa N., Yaegashi T., Ishisaki A. "Enhancementof anti-inflammatory and osteogenic abilities of mesenchymal stem cells via cell-to-celladhesion to periodontal ligament-derived fibroblasts". Stem Cells International,
2017:3296498, 2017. *co-first authors.
③Aomatsu E., Takahashi N., Sawada S., Okubo N., Hasegawa T., Taira M., Miura H.,

帖佐直幸

生化学講座細胞情報科学分野准教授

博⼠（地球環境科学）

常態系口腔科学関連、 Ishisaki A., Chosa N. "Novel SCRG1/BST1 axis regulates self-renewal, migration, and
医科学関連、免疫学関 osteogenic differentiation potential in mesenchymal stem cells". Scientific Reports,連4:3652, 2014.
④Jang I.H.*, Chosa N.*, Kim S.H., Nam H.J., Lemaitre B., Ochiai M., Kambris Z., Brun S.,
Hashimoto C., Ashida M., Brey P.T., Lee W.J. "A Spatzle-processing enzyme isindispensable for Toll signaling activation in Drosophila innate immunity".
Developmental Cell, 10:45-55, 2006. *co-first authors.
⑤Chosa N.*, Taira M.*, Saitoh S., Sato N., Araki Y. "Characterization of apatite formedon alkaline-heat-treated Ti". Journal of Dental Research, 83:465-469, 2004. *co-firstauthors.

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主な論文・著作・業績①Yokota S., Chosa N., Kyakumoto S., Kimura H., Ibi M., Kamo M., Satoh K., Ishisaki A.
"ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-likesynoviocytes derived from the temporomandibular joint". International Journal of
Molecular Medicine, 39:799-808, 2017.
②Takizawa N.*,Okubo N.*,Kamo M.,Chosa N.,Mikami T.,Suzuki K.,Yokota S.,IbiM.,Ohtsuka M.,Taira M.,Yaegashi Y.,Ishigaki A.,Kyakumoto S. "Bone marrow-derived
mesenchymal stem cells propagate immunosuppressive/anti-inflammatory
macrophages in cell to cell contact-independent and -dependent manners underhypoxic culture".Experimental Cell Research, 358:411-420,2017.*co-first authors.
③Nemoto A.,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Noda M.,Ishisaki A.,"Water-横田聖司

生化学講座細胞情報科学分
野助教

博⼠（⻭学）

soluble factors eluated from surface pre-reached glass ionomer filler promote
常態系口腔科学関連、 osteoblastic differentiation of human mesenchymal stem cells".Molecular Medicine
病態系口腔科学関連

Reports. 17:3448-3454. 2018.
④Ohta M.*,Nemoto A.*,Chosa N.,Kyakumoto S.,Yokota S.,Kamo M.,Shibata S.,JohS.,Satoh K.,Ishisaki A. "Toll-like receptor 4-mediated signaling activated bylipopolysaccharide suppresses transforming growth factor-beta-induced nerve growth
factor expression in periodontal ligament-derived fibroblasts".Dental Journal of Iwate
Medical University. 43:61-73. 2018.*co-first authors.
⑤Ohta M.,Chosa N.,Kyakumoto S.,Yokota S.,Okubo N.,Nemoto A.,Kamo M.,Joh S.,SatohK.,Ishisaki A. "IL-1β and TNF-α suppress TGF-β-promoted NGF expression inperiodontal ligament-derived fibroblasts through inactivational of TGF-β-induced
Smad2/3-, and p38 MAPK-mediated signals".International Journal of MolecularMedicine. 43:1484-1494. 2018