13．Department of Safety Researchon Blood and Biological Products

Kobayashi N, Oda H, Mori M, Kobayashi A, Taneichi M,+Uchida T, Akatsuka T: Highly efficient anti-viral CD8 T
cell induction by peptides coupled to the surface of1) Yamazaki J, Mizukami T, Takizawa K, Kuramitsu M,liposomes. Clin Vaccine Immunol. 16: 1383-1392,Momose H, Masumi A, Ami Y, Hasegawa H, Hall WW,
Tsujimoto H, Hamaguchi I, Yamaguchi K: Identification

20098) Kohyama S, Ohno S, Suda T, Taneichi M, Yokoyamaof cancer stem cells in a Tax-transgenic (Tax-Tg)

S, Mori M, Kobayashi A, Hayashi H, Uchida T, Matsui

mouse model of adult T- cell leukemia / lymphoma

M: Efficient induction of cytotoxic T lymphocytes(ATL). Blood. 114: 2709-2720, 2009

spscificfor

severeacuterespiratory

syndrome2) Mizuochi T, Ito M, Takai K, Yamaguchi K: Differential(SARS)-associated coronavirus by immunization withsusceptibility of peripheral blood CD5+ and CD5− B

surface-linked liposomal peptides derived from acells to apoptosis in chronic hepatitis C patients.

non-structual polyprotein 1a. Antivir Res. 84: 168-177,

Biochem Biophys Res Commun. 389: 512-515,200920099) Mohsan S, Suzuki R, Kondo M, Aizaki H, Kato T,

3) Ito M, Mizoroki F, Takai K, Yamaguchi K, Mizuochi T:
Phenotypes

andgeneexpression

profilesMizuochi T, Wakita T, Watanabe H, Suzuki T:ofEvaluation of hepatitis C virus core antigen assays forperipheral blood mononuclear cells in chronic hepatitis

detecting recombinant viral antigens derived fromC patients who developed non-Hodgkin’s B-cell

various genotypes. J Clin Microbiol. 47:4141-4143,lymphoma.

2009.

Biochem Biophys Res Commun. 390: 269-272,10) Ichinohe T, Ainai A, Nakamura T, Akiyama Y,

2009

Maeyama J, Odagiri T, Tashiro M,Takahashi H, Sawa

4) Kasai M, Tanida I, Ueno T, Kominami E, Seki S, Ikeda

H, Tamura S, Chiba J, Kurata T, Sata T, Hasegawa H:T, Mizuochi T: Autopahgic compartments gain accessInduction

toinfluenza A virus H5N1 by an intranasal vaccine withtheMHCclassII-compartments

inthymicof cross-protective immunity against

epithelium.

extracts of mushroom mycelia. J Med Virol. 82:J Immunol. 183: 7278-7285, 2009128-137, 20105) Murakami T, Kumakura S, Yamazaki T, Tanaka R,11) Mizuochi T, Mizusawa S, Nojima K, Okada Y,Hamatake M, Okuma K, Huang W, Toma J, Komano J,

Yamaguchi K: Single amino acid substitution in theYanaka M, Tanaka Y, Yamamoto N: The novel CXCR4

hepatitis

antagonist, KRH-3955 is an orally bioavailable anddeterminant affects the detection sensitivity of an

extremely potent inhibitor of human immunodeficiency

HBsAg diagnostic kit. Clin Chim Acta. 411: 605-606,virus type 1 infection: comparative studies with2010

AMD3100. Antimicrob Agents Ch. 53: 2940-2948,12)

2009

B

virus

surfaceantigen(HBsAg)“a”

Matsui M, Kohyama S, Suda T, Yokoyama S, Mori

M, Kobayashi A, Taneichi M, Uchida T: A CTL-based

6) Masumi A, Hamaguchi I, Kuramitsu M, Mizukami T,

liposomal vaccine capable of inducing protection

Takizawa K, Momose H, Naito S, Yamaguchi K:againstheterosubtypic

influenzaviruses

innterferon Regulatory factor-2 induces megakaryopoiesis

HLA-A*0201 transgenic mice. Biochem Biophys Res

in mouse bone marrow hematopoietic cells. FEBS Lett.

Commun. 391: 1494-1499, 2010

538: 3493-3500, 200913)

7) Takagi A, Matsui M, Ohno S, Duan H, Moriya O,Mizuochi T, Ito M, Saito K, Kasai M, Kunimura T,

Morohoshi T, Morohoshi T, Momose H, Hamaguchi I,1

Takai K, Iino S, Suzuki M, Mochida S, Ikebuchi K,CK, Lee CK, Tsoi WC, Lawlor E, Grazzini G, Piccinini

Yamaguchi K: Possible recruitment of peripheral blood

V, Catalano L, Pupella S, Kato H, Takamoto S, Okazaki

CXCR3+CD27+CD19+B cells to the liver in chronic

H, Hamaguchi I, Wiersum-Osselton JC, vanhepatitis C patients. J Interf Cytok Res. 30: 243-252,Tilborgh AJW, Zijlker-Jansen PY, Mangundap KM,

2010

Schipperus MR, Dinesh D, Flanagan P, Flesland Ø, C.

14) Momose H, Imai J, Hamaguchi I, Kawamura M,

Steinsvåg CT, Espinosa A, Letowska M, Rosiek A,Mizukami T, Naito S, Masumi A, Maeyama J, Takizawa

Antoniewicz-Papis J, Lachert E, Koh MBC, Alcantara R,K, Kuramitsu M, Nomura N, Watanabe S, Yamaguchi

Corral Alonso M, Muñiz-Diaz E: Haemobigilance for theK:

optimal use of blood products in hospital.

Inductionofindistinguishable

gene

expression

Vox Sanguinis. in press

patterns in rats by Vero cell-derived and mouse20) Ito M, Murakami K, Suzuki T, Mochida K, Suzuki M,

brain-derived Japanese encephalitis vaccines. Jpn J

Ikebuchi K, Yamaguchi K, Mizuochi T: Enhanced

Infect Dis. 63: 25-30.2010

expression of lymphomagenesis-related genes in15) Nagai Y, Asaoka Y, Namae M, Saito K, Momose H,

peripheral B cells of chronic hepatitis C patients.

Mitani H, Furutani-Seiki M, Katada T, Nishina H: TheClin Immunol. in press

LIM protein Ajuba is required for ciliogenesis and21) Ito M, Masumi A, Mochida K, Kukihara H, Moriishi K,

left-right axis determination in medaka. Biochem

Matsuura Y, Yamaguchi K, Mizuochi T: Peripheral B

Biophys Res Commun. 396: 887-93, 2010

cells may serve as a reservoir for persistent infection16) Masumi A, Ito M, Mochida K, Hamaguchi I, Mizukami

of hepatitis C virus. J Innate Immun. in press

T, Momose H, Kuramitsu M, Tsuruhara M, Takizawa K,22) Uchiumia F, Enokida K, Shiraishia T, Masumi A,

Kato A, Yamaguchi K: Enhanced RIG-I expression isTanuma S: Characterization of the promoter region ofmediated by interferon regulatory factor-2 in peripheral

the human IGHMBP2 (Smbp-2) gene and its response

blood B cells from hepatitis C virus-infected patients.

to TPA in HL-60 cells. Gene. in press

Biochem Biophys Res Commun. 391: 1623-1628,
201017) Tehranchi R, Woll PW, Anderson K, Buza-Vidas N,MizukamiT,

MeadAJ,Åstrand-Grundström

I,

Strömbeck B, Horvat A, Ferry H, Dhanda RS, Hast R,Rydén T, Vyas P, Göhring G, Schlegelberger B,
Johansson B,

Hellström-Lindberg E, List A, Nilsson L

and Jacobsen SE: Persistent Malignant Stem Cells indel(5q) Myelodysplastic Syndrome in Remission.
New Engl J Med. in press18) Momose H, Mizukami T, Ochiai M, Hamaguchi I,Yamaguchi K: A New Method for the Evaluation of
Vaccine Safety Based on Comprehensive GeneExpression Analysis. J Biomed Biotech. in press19) Reesink HW, Panzer S, Gonzalez CA, Gimbatti S,Wood E, Lambermont M, Deneys V, Sondag D, Alport T,Towns D, Devine D, Turek P, Auvinen M-K, Koski T, Lin2