４．Department of Bacteriology Ⅰ

Watanabe H, Kishimoto T, Shirai M, Kurane I, Ando
S: Diagnostic assay for Rickettsia japonica. Emerg1) Arakawa T, Fujimaru T, Ishizaki T, Takeuchi H,Infect Dis 2009, 15: 1994-1997.

Kageyama M, Ikemi T, Hanada N, Watanabe H, Senpuku

9) Hanaoka N, Sakata A, Takano A, Kawabata H, Watanabe

H: Unique functions of hydroxyapatite to adherence

H, Kurane I, Kishimoto T, Ando S: Development ofof mutans streptococci. Quint Int 2010, 41:e11-9.

a pUC19-based recombinant plasmid to serve as a2) Bhuiyan NA,Bhuiyan NA, Nusrin S, Alam M, Morita

positive control in PCR for Orientia tsutsugamushi.
Microbiol Immunol 2009, 53: 305-308.

M, Watanabe H, Ramamurthy T, Cravioto A, Nair GB:
Changing genotypes of cholera toxin (CT) of Vibrio10) Helbig JH, Amemura-Maekawa J: Serotyping ofcholerae O139 in Bangladesh and description ofLegionella

three new CT genotypes. FEMS Immunol Med Microbiol

investigations. Nowa Medycyna 2009, 16:69-75.

2009, 57: 136-141.

pneumophilaandepidemiological11) Hirata Y, Sata M, Makiuchi Y, Morikane K, Wada A,

3) Nusrin S, Alam M, Morita M, Watanabe H, Ramamurthy

Okab Ne, Tomoike H: Comparative analysis ofT, Cravioto A, Nair GB: Changing genotypes ofMicrococcus luteus isolates from blood culture ofcholera toxin (CT) of Vibrio cholerae O139 inpatients with pulmonary hypertension receiving

Bangladesh and description of three new CT

epoprostenol continuous infusion. J. Infect.

genotypes.

Chemother. 2009, 15:424-425.

4) Chang B, Taguri T, Sugiyama K, Amemura-Maekawa J,12) Honda N, Iyoda S, Yamamoto S, Terajima J, Watanabe

Kura F, Watanabe H: Comparison of ethidium

H: LrhA positively controls the expression of themonoazide

locusandpropidium

monoazidefortheofenterocyte

effacement

Escherichia

genes

incolibyselective detection of viable Legionella cells.

enterohemorrhagic

Jpn J Infect Dis 2010, 63: 119-123.

differential regulation of their master regulators

5) Chiou CS, Watanabe H, Wang YW, Wang WL, Terajima

PchA and PchB. Mol Microbiol 2009, 74:1393-1411.

J, Thong KL, Phung DC, Tung SK: Utility of13) Ikebe T, Ato M, Matsumura T, Hasegawa H, Sata T,

multilocus variable-number tandem-repeat analysis

Kobayashi K, Watanabe H: Highly frequent mutations

as a molecular tool for phylogenetic analysis ofin negative regulators of multiple virulence genes

Shigella sonnei. Journal of Clinical Microbiology

in group A streptococcal toxic shock syndrome

2009, 47:1149-54.

isolates. PLoS Pathog 2010,6:e1000832.

6) Fujibayashi T, Nakamura M, Tominaga A, Satoh N,14) Inaba E, Uematsu H, Nishiyama Y, Watanabe H,Kawarai T, Narisawa N, Shinozuka O, Watanabe H,Senpuku H: The role of anti-PAc (361-386) peptide

Yamazaki T, Senpuku H: Effects of IgY against

SIgA antibody in professional oral hygiene of theCandida albicans and Candida spp. adherence andelderly. Gerodontol 2009, 26:259-267.

biofilm formation. Jpn J Infect Dis 2009, 62:15) Izumiya H, Tada Y, Ito K, Morita-Ishihara T,

337-342.

OhnishiM,TerajimaJ,WatanabeH:7) Fujioka K, Arakawa E, Kita J, Aoyama Y, Okuda T,Characterization of Shigella sonnei isolates from

Manome Y, Yamamoto K: Combination of real-value

travel-associated cases in Japan. J Med Microbiolsmell and metaphor expression aids yeast detection.

2009, 58: 1486-1491.

PLoS One. 2009 Nov 20;4(11):e7939.

16) Koba H, Okuda K, Watanabe H, Tagami J, Senpuku H:8) Hanaoka N, Matsutani M, Kawabata H, Yamamoto S,

Role of lysine in interaction between surface

Fujita H, Sakata A, Azuma Y, Ogawa M, Takano A,protein peptides of Streptococcus gordonii and1

201- 205.

agglutinin peptide. Oral Microbiol Immunol 2009,25) Matsui-Inohara H, Uematsu H, Narita T, Satoh K,

24:162-169.
17) Kobayashi H, Kanazaki M, Ogawa T, Iyoda S,Yonezawa H, Kuroda K, Ito T, Yoneda S, Kawarai T,

Hara-Kudo Y: Changing prevalence of O-serogroups

Sugiya H, Watanabe H, Senpuku H: E2F-1-deficientandNOD/SCID mice developed showing decreased saliva

antimicrobial

susceptibility

amongSTEC

strains isolated from healthy dairy cows over aproduction. Exp Biol Med 2009, 234:1525-1536.

decade in Japan between 1998 and 2007. J Vet Med26) Matsumoto M, Yamaguchi I, Sasano M, Hori M,
Ikezaki K, Shimizu S, Nishiyama Y, Sato N,Sci 2009, 71: 363-366.

TsuchiyaH, Suzuki M, Minagawa H, Working Group for18) Koizumi N, Gamage CD, Muto M, Kularatne SAM,
Budagoda SBDS, Rajapakse JRPV, Tamashiro H,

Beta-Haemolytic

StreptococciinJapan:

Watanabe H:

Serological and genetic analysis ofserotyping of Streptococcus pyogenes in Aichi

leptospirosis in patients with acute febrile

Prefecture, Japan isolated between 2003 and 2007.

illness in Kandy, Sri Lanka. Jpn J Infect Dis 2009,Jpn J Infect Dis 2009, 62:168-169.
27) Matsuura M, Takahashi H, Watanabe H, Kawahara K:

62:474-475.

Immunomodulatory19) Koizumi N, Muto M, Tanikawa T, Mizutani H, Sohmura

effects

Yersinia

lipopolysaaccharides

Watanabe

Clinical Vaccine Immunol 2010, 17:49-55

Human

leptospirosis

cases

andonofY, Hayashi E, Akao N, Hoshino M, Kawabata H,
H:T

human

pestismacrophages.

Leptospira28) Morita-Ishihara T, Terajima J, Watanabe H,interrogans in urban areas of Tokyo, Japan. J MedIzumiya H: Interaction between Enterohemorrhagic

Microbiol 2009, 58: 1227-1230.

Escherichia coli O157:H7 EspFu and IRSp53 induces

prevalenceofrats

harboring20) Koizumi N, Muto M, Yamada A, Watanabe H:

dynamic membrane remodeling in epithelial cells.

Prevalence of Leptospira spp. in the kidneys ofwild boars and deer in Japan. J Vet Med Sci 2009,

Jpn J Infect Dis 2009, 62: 351-355.
29) Nakamura M, Fujibayashi T, Tominaga A, Satoh N,

71: 797-799.

Kawarai T, Shinozuka O, Watanabe H, Yamazaki T,21) Koizumi N, Uchida M, Makino T, Taguri T, Kuroki

Senpuku H: Hinokitiol inhibits Candida albicans

T, Muto M, Kato Y, Watanabe H: Isolation andadherence to oral epithelial cells, J Oral Biosci

characterization of Leptospira spp. from raccoons

2010, 52: 42-50.

in Japan. J Vet Med Sci 2009, 71:425-429.
22) Koizumi

N,Watanabe

H:Leptospirosis.

30) Niwa H, Anzai T, Izumiya H, Morita-Ishihara T,
In:Watanabe

H,UchidaI,Tozaki

Vaccines for Biodefense and Emerging and NeglectedAntimicrobial

resistanceDiseases 2009, 1291-1308. Elsevier, UK.

characteristicsof

H: Inhibiting effects ofEnterococcus

faecium

non-biofilm

Streptococcus

mutansbiofilm

andSalmonella

Hobo

S:

genetic

typhimiruim

isolated from horses in Hokkaido, Japan. J Vet Med23) Kumada M, Motegi M, Nakao R, Yonezawa H, Yamamura
H, Tagami J, Senpuku

T,Sci 2009, 71: 1115-1119.

strainon31) Ohnishi M, Watanabe Y, Ono E, Takahashi C, Oya H,formation.

JKuroki, T, Shimuta K, Okazaki N, Nakayama S,Microbiol Immunol Infect 2009, 42: 188-196.

WatanabeH:

Spreadofachromosomal

F:

cefixime-resistant penA gene among different

Bathwater-associated cases of legionellosis inNeisseria gonorrhoeae lineages. Amtimicrobial

24) Kuroki

Japan,T,

withIshiharaaspecial

T,

Ito

focus

K,

on

Kura

Legionella

concentrations in water. Jpn J Infect Dis 2009, 62:

Agents Chemothera. 2010, 54 1060-1067.
32) Onoyama S, Ogata R, Wada A, Saito M, Okada K,2HaradaT: Neonatal bacterial meningitis caused by40) Takada N, Fujita H, Kawabata H, Ando S, Sakata A,

Streptococcus gallolyticus subsp. pasteurianus. J.

Takano A: Chaithong U. Spotted feverMed. Microbiol. 2009, 58:1252-1254.

Rickttsia sp. closely related to Rickettsia

groupjaponica, Thailand. Emerg Infect Dis 2009, 15:33) Ooka T, Ogura Y, Asadulghani M, Ohnishi M,610-611.

Nakayama K, Terajima J, Watanabe H, Hayashi T:
Inference of the impact of insertion sequence (IS)41) Takano A, Ando S, Kishimoto T, Fujita H, Kadosaka

elements on bacterial genome diversification

T, Nitta Y, Kawabata H, Watanabe H: Novel Ehrlichia

through

structuralsp. found in Ixodes granulatus infested to rodents

polymorphisms in Escherichia coli O157 genomes.

in Okinawa, Japan. Microbiol Immunol 2009, 53:

Genome Research 2009, 19:1809-16.

101-106.

analysisof

small-size34) Ooka T, Terajima J, Kusumoto M, Iguchi A, Kurokawa42) Takano A, Muto M, Sakata A, Ogasawara Y, Ando S,K, Ogura Y, Asadulghani M, Nakayama K, Murase K,Hanaoka N, Tsurumi M, Sato F, Nakamura N, Fujita

Ohnishi M, Iyoda S, Watanabe H, Hayashi T:

H, Watanabe H, Kawabata H: Relapsing

Development of a multiplex PCR-based rapid typing

spirochete in seabird tick, Japan. Emerg Infect Dis

method for enterohemorrhagic Escherichia coli O157

2009, 15: 1528-1530.

strains. Journal of Clinical Microbiology 2009,fever43) Takaya A, Kitagawa N, Kuroe Y, Endo K, Okazaki M,

47:2888-94.

Yokoyama E, Wada A, Yamamoto T: Mutational analysis

35) Sakamoto R, Ohno A, Nakahara T, Satomura K,ofreduced

telithromycin

susceptibilityofIwanaga S, Kouyama Y, Kura F, Kato N, Matsubayashi

Streptococcus pneumoniae isolated clinically inK, Okumiya K, Yamaguchi K: Legionella pneumophila

Japan. FEMS Microbiol. Lett. 2010, 307:87-93.

in rainwater on roads. Emerg Infect Dis 2009, 15:44) Tamura S, Yonezawa H, Motegi M, Nakao R, Yoneda

1295 –1297.

S, Watanabe H, Yamazaki T, Senpuku H: Inhibiting36) Sakamoto R, Ohno A, Nakahara T, Satomura K,

effects of S. salivarius on CSP-dependent biofilm

Iwanaga S, Koyama Y, Kura F, Noami M, Kusaka K,formation bu mutans streotococci. Oral Microbiol

Funato T, Takeda M, Okumiya K, Kato N, Yamaguchi

Immunol 2009, 24:152-161.

K: Is driving a car a risk for Legionnaires disease?

45) Toh H, Oshima K, Toyoda A, Ogura Y, Ooka T,
Sasamoto H, Park SH, Iyoda S,Kurokawa K, Morita H,Epidemiol Infect 2009, 137: 1615-1622.

Itoh K, Taylor TD, Hayashi T, Hattori M：Complete37) Sato H, Takano A, Kawabata H, Une Y, Watanabe H,Mukhtar MM: Trypanosoma cf. varani in an importedgenomeball pythone (Python regnus) from

Escherichia

Ghana. JParasitol 2009, 95: 1029-1033.

sequencecoliofthestrain

wild-type
SE15,

commensal

belonging

tophylogenetic group B2. J Bacteriol 2010, 192:38) Shimuta K, Ohnishi M, Iyoda S, Goto N, Koizumi N,

1165-1166.

Watanabe H: The hemolytic and cytolytic activities46) Yamamoto S, Morita M, Izumiya H, Watanabe H:of Serratia marcescens phospholipase A (PhlA)

Chitin disaccharide (GlcNAc)2 induces naturaldepend on lysophospholipid production by PhlA. BMC

competence

Microbiology 2009, 9:261.

transcriptional and translational activation of ain

Vibriocholeraethroughpositive regulatory gene tfoXVC. Gene 2010,39) Suzuki T, Mochizuki S, Yamamoto S, Arakawa H,

457:42-49.

Kinashi H: Regulation of lankamycin biosynthesis
in Streptomyces rochei by two SARP genes, srrY and47) Yamauchi T, Tabara K, Kanamori H, Kawabata H, Arai

srrZ. Biosci Biotechnol Biochem 2010, 74:819-827.

S, Katayama T, Fujita H, Yano Y, Takada N, Itagaki
3

A: Tick fauna associated with sika deer density inthe Shimane Peninsula, Honshu, Japan. Med Entomol
Zool 2009, 60: 297-304.
48) Mohsan S, Suzuki R, Kondo M, Aizaki H, Kato T,MizuochiT,

WakitaT,

WatanabeH,Suzuki

T.Evaluation of hepatitis C virus core antigen
assays in detecting the recombinant viral antigensof various genotypes.J Clin Microbiol. 2009,
47:4141-4143.
49) Hasegawa M, Inamo Y, Fuchigami T, Hashimoto K,
Morozumi M, Ubukata K, Watanabe H, Takahashi T.
Bronchial casts and pandemic (H1N1) 2009 virus
infection.Emerg Infect Dis. 2010,16(2):344-346.
50) Shiino T, Okabe N, Yasui Y, Sugawara A, Ujike M,Obuchi M,Kishida

N, Hong Xu, Takashita E, Anraku

A, Ito R, Doi T, Ejima M, Sugawara H, Horikawa H,Yamazaki S, Kato Y, Fujita N, Odagiri T, TashiroM, and Watanabe H. Molecular evolutionary analysisof the influenza A(H1N1)pdm viruses, May-September,
2009: Temporal and spatial spreading profile ofviral isolates in Japan.2010, PloS One.10: 5,e11057.
51) Niaz Rahim, D. J. Gomes, H. Watanabe, Sabita R.
Rahman, Alejandro Cravioto, Hubert Ph. Endtz, andMunirul Alam.

Antibacterial activity of Psidium

guajava leaf and bark against multi-drug resistantVibrio cholerae: implication for cholera control.
Jpn.J. Inf.Dis.2010, 63: 271-274.
52) Benacer D, Thong KL, Watanabe H, Puthucheary SD.
Characterization of drug resistant Salmonella

enterica Serotype Typhimurium by antibiograms,plasmids, integrons, resistance genes and PFGE.
Journal of Microbiology and Biotechnology.2010,20: 1042-1052.

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