ISSN 1513-7368
Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNALOF

CANCER PREVENTIONThe Official Publication of the Asian Pacific Organization forCancer Prevention and the UICC Asia Regional Office for Cancer Control
An Official Journal of the International Association of Cancer Registries

Volume 10,
Number 1, 2009100

P=0.0001
10

LowestHighestFigure fromFranky D Shah et al ,pp 91-96

1

Q1

Q2

Q3

Q4
P=0.0001

0.1

asian cancer control

Etiology

P=0.0001
P=0.003
0.01

Quartile Distribution

APOCP Areas
Australasia
Central Asia
Chinab-carotene

Vitamin A

Vitamin E

Vitamin C

Analytical and Clinical
Epidemiology

Japan

Breast Lesion

Korea

FNAC

South Asia
Definite Diagnosis

Equivocal

South-East Asia
Western Asia

Diagnostics

CNB
Definite Diagnosis

APJCP

Equivocal
Excision Biopsy

Figure from Teck-Meng Tham et al ,pp 153-156

Clinical Treatment Education
Epidemiology
Intervention
Palliation
Screening Toxicological Pathology

Definite Diagnosis

http://www.apocp.org
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNAL OF CANCER PREVENTIONAPJCP Chief Editor

APOCP Secretary-General

APOCP President

Malcolm A Moore
APJCP Editorial Office,
UICC Asia Regional Office
apocpcontrol@yahoo.com

Keun-Young Yoo
Department of Preventive Medicine,
Seoul National University, Korea
kyyoo@plaza.snu.ac.kr

Murat Tuncer
Department of Cancer Control,
Ministry of Health, Turkey
murat.tuncer@saglik.gov.tr

Subject Editors - Epidemiology

Subject Editors - Toxicological Pathology

Daehee Kang
Seoul National University, Seoul, Korea
dhkang@snu.ac.kr
Alireza Mosavi-Jarrahi
Shahid Beheshti University, Tehran, Iranrmosavi@yahoo.com
Shinkan Tokudome
Nagoya City University, Nagoya, Japan
tokudome@med.nagoya-cu.ac.jp

Sukta Das
Chittaranjan National Cancer Institute, Kolkata, India
suk_tadas@yahoo.com
Dae Joong Kim
Chungbuk National University, Cheongju, Korea
kimdj@cbu.ac.kr
Hiroyuki Tsuda
Nagoya City University, Nagoya, Japan
htsuda@med.nagoya-cu.ac.jp

Subject Editors - Education/Registration

Subject Editors - Screening and Intervention

Supannee Sriamporn
KhonKaen University, KhonKaen, Thailand
supannee@kku.ac.th
Suraporn Wiangnon (IACR Representative)
Khon Kaen University, Khon Kaen, Thailand
surapon@kku.ac.th
Balkrishna B Yeole
Bombay Cancer Registry, Indian Cancer Society, India
bcrics@vsnl.com

Partha Sarathi Basu
Chittaranjan National Cancer Institute, Kolkata, India
ceds@vsnl.com
Tony Hsui-Hsi Chen
National Taiwan University, Taipei, Taiwan
chenlin@ntw.edu.tw
Yun-Chul Hong
Seoul National University College of Medicine, Korea
ychong1@snu.ac.kr

Aims and Scope
The aim of the Asian Pacific Organization for Cancer Prevention and Control is to promote an increased awarenessin all areas of cancer prevention/control and to stimulate research and practical intervention approaches. Its official
journal, the APJCP, is indexed on PubMed and Science Citation Index Expanded. The scope is wide-ranging, including
descriptive, analytical and molecular epidemiology, experimental and clinical histopathology/biology of preneoplasias
and early neoplasias, assessment of risk and beneficial factors, experimental and clinical trials of primary preventive
measures/agents, screening approaches and secondary prevention, clinical epidemiology and all aspects of cancer
prevention education. All of the papers published are freely available as pdf files downloadable from www.apocp.org
or obtainable from the first authors.

International Advisory Board
Yoon-Ok Ahn, Seoul
Gülsün Ozentürk, Izmir
Junshi Chen, Beijing
Yu-Tang Gao, Shanghai
Tadao Kakizoe, Tokyo
Tomoyuki Kitagawa, Tokyo
Adriano Laudico, Manila
Noorwati, Jakarta
Maqsood Siddiqi, Kolkatta
Takashi Sugimura, Tokyo
Kazuo Tajima, Nagoya
Do Duc Van, Hanoi
APJCP Vol 10., No 1

Kunio Aoki, Nagoya
Fahanar Badar, Lahore
Santoso Cornain, Jakarta
P Gangadharan, Kochin
Thiravud Khuhaprema, Bangkok
Hiroshi Kobayashi, Sapporo
MA Mohagheghi, Tehran
Max Parkin, London
Soeripto, Yogyakarta
Young-Joon Surh, Seoul
Suketami Tominaga, Nagoya
Minro Watanabe, Iwate

MAY Ariyaratna, Colombo
Yasmin Bhurgri, Karachi
Somyos Deerasamee, Bangkok
Sagimbek Igisinov, Almaty
Chaudhry Kishore, New Delhi
Arun P Kurkure, Mumbai
Nadeem Nagi, Sana’a
Bhakta Man Shrestha, Kathmandu
Petcharin Srivatanakul, Bangkok
Maitree Suttajit, Chiang Mai
Tumubaatar, Ulaanbaatar
Cheng Har Yip, Kuala Lumpur

Asian Pacific Organization for Cancer Prevention and Control

Editorial Board

ASIAN PACIFIC JOURNALOF

CANCER PREVENTIONThe Official Publication of the
Asian Pacific Organization for Cancer Prevention and Control
and the UICC-Asian Regional Office for Cancer Control
and an Official Journal of theInternational Association of Cancer Registries
CONTENTS
Volume 10, Number 1, January-February 2009
EDITORIAL
What is the Future for the Asian Pacific Journal of Cancer
Prevention (and Control) and the Asian Pacific Organization forCancer Prevention (and Control)?
Malcolm A Moore et al
.
.
.
.
.
.

1

REVIEW
Cancer Epidemiology and Control in the Arab World - Past, Present
and Future Elsayed I Salim et al
.
.
.
.
.

3

RESEARCH COMMUNICATIONS
Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2
Polymorphisms in Uzbekistan
Keun Soo Ahn et al
.
.
.
.
.

.

17

GSTM1, GSTT1 and CYP1A1 Polymorphisms and Risk of Oral Cancer:
a Case-control Study in Jakarta, Indonesia
Rahmi Amtha et al
.
.
.
.
.
.
.

21

Human Papillomavirus Genotype Distribution in Cervical Cancer
in India: Results from a Multi-center Study
Partha Basu et al
.
.
.
.
.
.
.

27

Impact of Consanguinity on Cancer in a Highly Endogamous Population
Abdulbari Bener et al
.
.
.
.
.

35

Rising Incidence of Gastric Malignancies in Karachi, 1995- 2002
Yasmin Bhurgri et al
.
.
.
.
.
.

41

Incidence and Trends of Prostate Cancer in Karachi South, ‘1995- 2002’
Yasmin Bhurgri et al .
.
.
.
.
.
.

45

Breast Cancer Screening Behavior in Turkish Women: Relationships
with Health Beliefs and Self-esteem, Body Perception and Hopelessness
Olcay Çam and Aysun Babacan Gümüs
.
.
.
.

49

Ethnic Disparities in Cancer Incidence among Residents of Guam
Robert L Haddock et al
.
.
.
.
.
.

57

Efficacy and Toxicity of Gemcitabine and Pegylated Liposomal
Doxorubicin in Recurrent Platinum-Resistant/Refractory Epithelial
Ovarian Cancer Aziz Karaoglu et al
.
.
.
.

63

Estimating the Incidence of Leukemia Attributable to Occupational
Exposure in Iran Alireza Mosavi-Jarrahi et al
.
.
.

67

Advantages of Second Line Estramustine for Overall Survival of
Hormone-Refractory Prostate Cancer (HRPC) Patients
Taku Naiki et al
.
.
.
.
.
.
.

71

Lifetime Risk and Trends in Lung Cancer Incidence in Greater Mumbai
Namrata Agarwal et al
.
.
.
.
.
.

75

Woong Sik Ahn, Seoul
Takayuki Akasu, Tokyo
Hideyuki Akaza, Tsukuba
Suminori Akiba, Kagoshima
Gürbüz Aktas, Izmir
Jamal M Arif, Riyadh
Morteza Atri, Tehran
Micha Barchana, Jerusalem
Chien-Jien Chen, Taipei
Jian-Guo Chen, Qidong
Kexin Chen, Tianjin
Kee-Seng Chia, Singapore
An-Sik Chung, Taejon
Santoso Cornain, Jakarta
Ratchada Cressey, Chiang Mai
Sultan Eser, Izmir
Sunia Foliaki, Tonga
William Foo, Hong Kong
Katsuhiro Fukuda, Kurume
Shoji Fukushima, Osaka
Mark T Goodman, Honolulu
Adele Green, Brisbane
Nobuyuki Hamajima, Nagoya
Tsutomu Hashimoto, Wakayama
Nurbek Igisinov, Astana
Gulnura Igisinov, Almaty
Saginbek Igisinov, Almaty
Gen Iinuma, Tokyo
Masato Ikeda, Kitakyushu
Katsumi Imaida, Kagawa
Manami Inoue, Tokyo
Takafumi Ishida, Tokyo
Hideki Ishikawa, Kobe
Yoshinori Ito, Nagoya
Tetsuya Kamataki, Sapporo
Jeongseon Kim, Goyang
Reiko Kishi, Sapporo
Yoichi Konishi, Nara
Suminori Kono, Fukuoka
Choong Won Lee, Daegu
Won Chul Lee, Seoul
Hiroshi Maeda, Kumamoto
Akihiko Maekawa, Tokyo
Le Bach Mai, Hanoi
Alleyama Mathew, Trivandrum
Parvin Mehdipour, Tehran
Anjum Memon, Kuwait
Masumi Minowa, Tokyo
Masanao Miwa, Tsukuba
Mitsuru Mori, Sapporo
Hideki Mori, Gifu
Masaki Nagai, Saitama
Kei Nakachi, Hiroshima
Dai Nakae, Tokyo
Hitoshi Nakagama, Tokyo
Masakazu Nakamura, Osaka
Hoyoku Nishino, Kyoto
LeTran Ngoan, Hanoi
Filiz Ogce, Izmir
Hiroko Ohgaki, Lyon
Hajime Ohigashi, Kyoto
Hiroshi Ohshima, Shizuoka
Yoshiyuki Ohno, Nagoya

APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control
Cooking Temperature, Heat-generated Carcinogens, and the Riskof Stomach and Colorectal Cancers
Le Tran Ngoan et al
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.
83
Spectrum of Thyroid Lesions in Hospital Universiti Sains Malaysia
Over 11-Years and A Review of Thyroid Cancers in Malaysia
Nor Hayati Othman et al
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87
Evaluation of Plasma Non-enzymatic Antioxidants in Breast
Cancer Etiology Franky D Shah et al
.
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91

Risk Factors for Hepatitis B Infection in Rural Vietnam
Thai Hong Duong et al
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.

97

.

Effects of Rhinacanthus nasutus Kurz on Colon Carcinogenesis
in Mice Piengchai Kupradinun et al
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103

Burden of Hospitalization for Gastrointestinal Tract Cancer
Patients - Results from a Cross-sectional Study in Tehran
Mohamad Amin Pourhoseingholi et al
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107

CYP17 (T-34C), CYP19 (Trp39Arg), and FGFR2 (C-906T)
Polymorphisms and the Risk of Breast Cancer in South Indian
Women Mani Samson et al
.
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.

111

Is there any Clinical Advantage in Separating CIN 2 fromCIN 3 in the Current Two-tiered Cytological Classification?
Sathone Boonlikit and Nattinee Srisantiroj
.
.
.

115

Expression and Clinical Significance of Tbx2 in Pancreatic
Cancer Song Duo et al
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.

119

Cancer Incidence Rates and the Problem of Denominators - a
New Approach in Indian Cancer Registries
Ramnath Takiar and B Shobana
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123

Glutathione S-Transferase Polymorphisms in Breast Cancers ofThai Patients
Tanett Pongtheerat et al
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127

Breast Cancer Knowledge, Risk Factors and Screening Among
Adult Saudi Women in a Primary Health Care Setting
Tarek Tawfik Amin et al
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133

E-flow Doppler Indices for Prediction of Benign and Malignant
Ovarian Tumors
Theera Tongsong et al .
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139

Genistein Mechanisms and Timing of Prostate Cancer
Chemoprevention in Lobund-Wistar Rats
Jun Wang et al
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143

Role of Heparanase-1 in Gastric Carcinoma Invasion
Xu Yingying et al
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151

Fine Needle Aspiration Biopsy, Core Needle Biopsy or Excision
Biopsy to Diagnose Breast Cancer - Which is the Ideal Method?
Teck-Meng Tham et al
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155

Establishment of an Integrated Management Model for theSecondary Prevention of Cervical Cancer- an Experience in Taiwan
Hospital Yu-Hua Yan et al
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159
Uterine Malignancy following Tamoxifen Use in Breast Cancer
Patients in Iran: Case Series and Literature Review
Nadereh Behtash et al .
.
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163

COMMENTARY
Epidemiology and Clinicopathology of Breast Cancer in Metro
Manila and Rizal Province, Philippines
Adriano Laudico et al
.
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.

167

Psychological and Social Adaptation of Women With Breast
Cancer Arzu Tuna Malak and Aysun Babacan Gümüs.

173

How to Search for Specific Markers of Cancer Stem Cells
Hai Guang Liu and Xiao Hua Zhang
.
.
.

177

APJCP Vol 10., No 1

Naoyuki Okamoto, Kanagawa
Toshihiko Osawa, Nagoya
Semih Ötles, Izmir
Ozgur Ozyilkan, Ankara
Kwang-Kyun Park, Seoul
Nguyen M Quoc, Ho Chi Minh CityR Rajkumar, Ambillikai
T Rajkumar, Chennai
Hiroshi Saito, Tokyo
Toshiyuki Sakai, Kyoto
Luming Shi, Singapore
Hai Rim Shin, Seoul
Tomoyuki Shirai, Nagoya
Hutcha Sripling, Songklaa
Songphol Srisukho, Chiang Mai
Toshiro Takezaki, Kagoshima
Takuji Tanaka, Kanazawa
Masae Tatematsu, Nagoya
Witaya Thamavit, Bangkok
Danai Tiwawech, Bangkok
Eiju Tsuchiya, Saitama
Ichiro Tsuji, Sendai
Hideaki Tsukuma, Osaka
Soo Jong Um, Seoul
Gajalakshmi Vendhan, Chennai
Keiji Wakabayashi, Tokyo
Hiroshi Watanabe, Kyoto
Hiromitsu Watanabe, Hiroshima
Yoshiyuki Watanabe, Kyoto
Viroj Wiwanitkit, Bangkok
Sopit Wongkham, Khon Kaen
Zentaro Yamagata, Yamanashi
Naohito Yamaguchi, Tokyo
Kenji Yamao, Nagoya
Takesumi Yoshimura, Kitakyushu
Shun-Zhang Yu, Shanghai
Yasuhito Yuasa, Tokyo

This pdf file is supplied free ofcharge by the Asian PacificOrganization for Cancer Prevention
and Control, in cooperation with the
UICC-Asian Regional Office forCancer Control and Asian Pacific
Press, Ltd.

PAE

Asian Pacific Organization for Cancer Prevention and Control

What is the Future for the Asian Pacific Journal of Cancer
Prevention (and Control) and the Asian Pacific Organization
for Cancer Prevention (and Control)?
Malcolm A Moore1, Keun-Young Yoo, Murat Tuncer (apocpcontrol@yahoo.com)
Mini-Abstract
The Asian Pacific Organization for Cancer Prevention was launched approximately 10 years ago withpublication of a booklet entitled ‘Introduction to Cancer Prevention in Tables and Figures’. This was followedby regular quarterly publication of the APJCP starting in the year 2000 - a new project for a new millenium and a number of research meetings held across Asia. The journal is now in its 10th year, indexed on PubMed andScience Citation Index (Expanded) and relatively well known (not least for its yellow cover). However, its future
after its tenth birthday remains uncertain, as there is no infrastructure in place to ensure continuation after
retirement of the present Chief/Managing Editor. The question of what might be the best way forward is thefocus for the present ‘Editorial Comment’. For financial as well as ecological reasons the APJCP is now anelectronic journal. While the costs are therefore relatively low and primarily limited to staff salaries, they doneed to be covered and it cannot be simply assumed that the present support provided by the UICC Japanese
National Committee will continue long-term. Therefore comments and suggestions are invited from all interested
individuals and institutions as to how the APJCP, and by extension the APOCP, should be organized andfinanced. All communications received will be given space in the next few issues of the APJCP so that discussion
can be fostered and informed decisions made at the 5th APOCP General Assembly Conference in Istanbul,
April 2010.
Asian Pacific J Cancer Prev, 10, 1-2

Cancer Epidemiology and Control in the Arab World - Past,
Present and Future Elsayed I Salim, Malcolm A Moore, Jawad A AlLawati, Jamal Al-Sayyad, Amin Bawazir, Abdulbari Bener, Marilys Corbex, Nagi
El-Saghir, Omran S Habib, Ibrahim Abdel-Barr Seif-Eldin, Tomotaka Sobue(apocpcontrol@yahoo.com)

Mini-Abstract
The Arab world, stretching from Lebanon and Syria in the north, through to Morocco in the west, Yemen in
the south and Iraq in the east, is the home of more than 300 million people. Cancer is already a major problem
and the lifestyle changes underlying the markedly increasing rates for diabetes mean that the burden of neoplasia
will only become heavier over time, In males, the most prevalent cancers vary, with lung, urinary bladder orliver in first place, while for females throughout the region breast cancer is the greatest problem. In both sexes,
non-Hodgkins lymphomas and leukemias are relatively frequent, along with thyroid cancer in certain female
populations. Adenocarcinomas of the breast, prostate and colorectum appear to be increasing. Coordination ofactivities within the Arab world could bring major benefits to cancer control in the eastern Mediterranean
region.
Asian Pacific J Cancer Prev, 10, 3 16

Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2
Polymorphisms in Uzbekistan
Keun Soo Ahn, Shavkat Abdiev,
Bakhodir Rahimov, Yusuf Malikov, Saidkarim Bahramov, Rieko Okada,Mariko Naito, Nobuyuki Hamajima (nhamajim@med.nagoya-u.ac.jp)
Mini-Abstract
The alcohol dehydrogenase 1B (ADH1B) *2 (47His) allele and the aldehyde dehydrogenase 2 (ALDH2) *2(487Lys) alleles are seen among some Asian peoples, but rare among other ethnic groups. This study examined
the allele frequencies in the Uzbekistan Republic, which is located in Central Asia. Subjects were derived froma case-control study on peptic ulcer disease, which included 161 Uzbeks and 23 Russians. The present study
demonstrated that ADH1B *2 allele frequency among Uzbeks was closer to that among Caucasians than East
Asians, some Uzbeks also demonstrating the ALDH2 *2 allele.
Asian Pacific J Cancer Prev, 10, 17-20
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

GSTM1, GSTT1 and CYP1A1 Polymorphisms and Risk ofOral Cancer: a Case-control Study in Jakarta, Indonesia
Rahmi Amtha, Cheong Sok Ching, Rosnah Zain, Ishak Abdul Razak,
Bastaman Basuki, Boedi Oetomo Roeslan, Walta Gautama, Denny Purwanto
Mini-Abstract(rahmi_amtha@yahoo.com)

To investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association with the risk oforal cancer in the Jakarta population., a total of 81 cases and 162 controls matched for age and sex were selectedfrom 5 hospitals. GSTM1 and GSTT1 null were slightly overrepresented among cases (60.5% and 45.7%
respectively) compared to controls (55.6% and 41.4% respectively), but no statistically significant differenceswere observed..
Asian Pacific J Cancer Prev, 10, 21-26

Human Papillomavirus Genotype Distribution in Cervical
Cancer in India: Results from a Multi-center Study
Partha Basu, Soma Roychowdhury, Uttam Das Bafna, Santanu Chaudhury,
Sarita Kothari, Rupinder Sekhon, Dhananjaya Saranath, Sutapa Biswas, Petter
Gronn, Ivan Silva, Maqsood Siddiqi, Sam Ratnam (chimed_bat@hotmail.com)
Mini-Abstract
Knowledge of HPV genotypes in cervical cancer covering the diverse Indian population is important inconsideration of the potential future impact of HPV prophylactic vaccination and HPV-based screening strategies.
To determine HPV genotype distribution in cervical cancers representing different regions a total of 278 cervicalcancer cases were enrolled from cancer centers in North, East, Central and South India. In total, types 16 and18 alone or in co-infection with each other were detected in 76.3% cases. Overall, genotypes 16, 18, 31, 33, and 45
were the five most common types, detected in 87.1% of the total. Asian Pacific J Cancer Prev, 10, 27-34

Impact of Consanguinity on Cancer in a Highly Endogamous
Population Abdulbari Bener, Hanadi R El Ayoubi, Lotfi Chouchane, Awab
I Ali, Aisha Al-Kubaisi, Haya Al-Sulaiti, Ahmad S Teebi ( hafize.ozturk@ege.edu.tr)
Mini-Abstract
The aim of this study was to examine whether parental consanguinity affects the risk of cancer in a local
Arab highly inbred population. The study findings revealed that although the consanguinity rate is high in
Qatar, it has no effect on the incidence of cancers overall. However, there was an increased risk found forleukemia and lymphoma, colorectal and prostate cancer groups, but a reduced risk in breast, skin, thyroid andfemale genital cancer groups.
Asian Pacific J Cancer Prev, 10, 35-40

Rising Incidence of Gastric Malignancies in Karachi, 19952002 Yasmin Bhurgri, Shahid Pervez, Naila Kayani, Samran Haider,
Rashida Ahmed, Ahmed Usman, Imtiaz Bashir, Asif Bhurgri1, Sheema H Hasan,
SMH Zaidi (yasmin.bhurgri@gmail.com)
Mini-Abstract
Gastric cancers in Karachi fall into the prototype of a low risk developing country pattern. The incidence isincreasing, most marked in males above 40 years of age. Larger pathology-based studies are required to commenton the precise morphological sub-types of gastric adenocarcinoma. Etiological studies focused on different strainsof H. pylori are required to address the gastric cancer enigma, whilst examining possible protective environmental
or genetic factors.
Asian Pacific J Cancer Prev, 10, 41-44
APJCP Vol 10., No 1

Asian Pacific Organization for Cancer Prevention and Control

Incidence and Trends of Prostate Cancer in Karachi South,‘1995- 2002’ Yasmin Bhurgri, Naila Kayani, Shahid Pervez, Rashida Ahmed,
Imran Tahir, Muneeza Afif, Ahmed Usman, Naveen Faridi, Imtiaz Bashir,
Asif Bhurgri, Sheema H Hasan, SMH Zaidi (yasmin.bhurgri@gmail.com)

Mini-Abstract

Cancer prostate (CaP) is a commonly diagnosed cancer in western men, but there is sparse information
about the demographics of this malignancy in Pakistan. The study objective was to provide an overview of CaP
in Karachi.n 1995-7, CaP accounted for approximately 3.4% of the cancers in males and ranked 8th in hierarchy
with an age standardized incidence rate (ASR) world and crude incidence rate (CIR) per 100,000 of 6.0 and 2.8
respectively. During 1998-2002, CaP accounted 4.6% of the cancers, ranked 4th with an ASR world and CIR per
100,000 of 10.1 and 4.4, an approximate 60% increase.
Asian Pacific J Cancer Prev, 10, 45-48

Breast Cancer Screening Behavior in Turkish Women:
Relationships with Health Beliefs and Self-esteem, Body
Perception and Hopelessness Olcay Çam, Aysun Babacan Gümüs
Mini-Abstract(aysungumus@gmail.com)

The purpose was to examine breast cancer screening behavior in Turkish women, the reasons for not doing
screening and the relationship between health beliefs and levels of self-esteem, body perception, and hopelessness.
This research was conducted as a descriptive, correlational study in an area covered by three neighborhood
primary health care clinics in Bornova, Izmir. It was found out that women with high level of self-esteem, highlevel of hope for the future and with a positive body perception have more positive health beliefs on breast
cancer screening.
Asian Pacific J Cancer Prev, 10, 49-56

Ethnic Disparities in Cancer Incidence among Residents of
Guam
Robert L Haddock, Helen JD Whippy, Rebecca J Talon,
Mini-Abstract

Melani V Montano (hwhippy@uguam.uog.edu)

Cancer incidence data collected by the Guam Cancer Registry for the period 1998 through 2002 were analyzed
by cancer site, age, and ethnicity. Chamorros (the indigenous people of the Mariana Islands) living on Guam
had a slightly lower total cancer incidence rate than the total U.S. population, but high age-adjusted incidence
rates for cancers of the mouth and pharynx, nasopharynx, liver, and cervix. Rates for prostate cancer, female
breast, ovary, colon-rectum-anus, leukemia, and non-Hodgkin lymphoma were all lower than U.S. rates. Similarvariation wa also noted for other ethnic groups.
Asian Pacific J Cancer Prev, 10, 57-62

Efficacy and Toxicity of Gemcitabine and Pegylated Liposomal
Doxorubicin in Recurrent Platinum-Resistant/Refractory
Epithelial Ovarian Cancer Aziz Karaoglu, Ulku Yalcintas Arslan,
Metin Ozkan, Mehmet Emin Kalender, Suleyman Alici, Ugur Coskun, Mahmut
Gumus, Gokhan Celenkoglu, Ozlem Er, Alper Sevinc, Suleyman Buyukberber,(azizk6@yahoo.com)
Necati Alkis, Mustafa Benekli
Mini-Abstract
Treatment of patients with platinum resistant/refractory ovarian cancer is a significant problem. In thisstudy, we evaluated the efficacy and tolerability of the combination of gemcitabine and pegylated liposomal
doxorubicin (PLD) in patients with platinum resistant/refractory ovarian cancer. Non-hematologic toxicity waswell tolerated and easily managed and no grade 3-4 palmoplantar erytrodysestesia was observed. The combinationof gemcitabine and PLD is an effective and tolerable treatment option, with 74.3 % disease control rate forpatients with platinum resistant/refractory ovarian cancer.
Asian Pacific J Cancer Prev, 10, 63-66
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

Estimating the Incidence of Leukemia Attributable to
Alireza Mosavi-Jarrahi,
Occupational Exposure in Iran
Mohammad Ali Mohagheghi, Bita Kalaghchi, Yasaman Mousavi-Jarrahi,
Ali Asghar Kolahi, Mohammad Kazem Noori (rmosavi@yahoo.com)

Mini-Abstract

The aim this study was to estimate the fraction of leukemia incidence in Iran attributable to occupational
exposure to benzene, ionizing radiation, and ethylene oxide. Methods: Nationwide exposure to each of theseleukemogens was estimated using workforce data available at the International Labor Organization website.
The prevalence of exposure to leukemogens in each industry was estimated using exposure data from the CAREX(CARcinogen EXposure) database. The conclusion was that the incidence of leukemia due to occupational
exposure is very low, although males are at greater risk than females.
Asian Pacific J Cancer Prev, 10, 67-70

Advantages of Second Line Estramustine for Overall Survivalof Hormone-Refractory Prostate Cancer (HRPC) Patients
Taku Naiki, Takehiko Okamura, Noriyasu Kawai, Hiroshi Sakagami,
Yasuyuki Yamada, Keiji Fujita, Hidetoshi Akita 1, Yoshihiro Hashimoto,Keiichi Tozawa, Kenjiro Kohri (hiko2546@kosei.anjo.aichi.jp)
Mini-Abstract
There is no effective standard therapy for the treatment of hormone refractory prostate cancer (HRPC), andtreatments vary among different medical institutions with efforts to improve results. A total of 142 patients with
HRPC were treated at Nagoya City University Hospital and its affiliate hospitals during the 10 years between
October 1996 and August 2006. Overall survival for all cases and particularly with those having a poorly
differentiated lesion, was best with estramustine phosphate in any time period. Although there is no generally
established optimal treatment for HRPC, our analysis supports the efficacy of EMP based on second line therapy
response rates and optimal prognosis with longer term use.
Asian Pacific J Cancer Prev, 10, 71-74

Lifetime Risk and Trends in Lung Cancer Incidence in Greater
MumbaiNamrata Agarwal, Balkrishna B Yeole, Usha Ram
Mini-Abstract(nagarwaliips@gmail.com)

The aim was to estimate the probability of developing lung cancer in the entire life span of the people ofGreater Mumbai and variation according to age and sex. The results show that age-adjusted incidence rates oflung cancer during the period 1982 to 2005 showed a statistically significant decreasing trend in males and astatistically significant increasing trend among females. The results clearly indicate that there has been a change
in the etiology of lung cancer in Greater Mumbai over time. The most important reason for this would bedecrease in smoking prevalence among males.
Asian Pacific J Cancer Prev, 10, 75-82

Cooking Temperature, Heat-generated Carcinogens, and the
Risk of Stomach and Colorectal Cancers
Le Tran Ngoan,
Nguyen Thi Thu, Nguyen Thi Lua, Lai Thi Minh Hang, Nguyen Ngoc Bich,
Nguyen Van Hieu, Ha Van Quyet, Le Thi Tai, Do Duc Van, Nguyen Cong Khan,
Le Bach Mai, Shinkan Tokudome, Takesumi Yoshimura (letngoan@hmu.edu.vn)
Mini-Abstract
Food change due to cooking temperature and unrecognized heat-formed chemical carcinogens may impact
on the risk of stomach and colo-rectal cancers. To test this hypothesis a case-control study was performed. The
results suggstthat observation of food change due to cooking temperature based on color is practically feasiblefor detecting associations with risk of developing cancer.
Asian Pacific J Cancer Prev, 10, 83-86
APJCP Vol 10., No 1

Asian Pacific Organization for Cancer Prevention and Control

Spectrum of Thyroid Lesions in Hospital Universiti Sains
Malaysia Over 11-Years and A Review of Thyroid Cancers in
Malaysia Nor Hayati Othman*, Effat Omar, Nyi Nyi Naing (hayati@kb.usm.my)
Mini-Abstract
Endemic goitre is a major concern in many nations including Malaysia.Thisretrospective study over an 11year period from 1994 to 2004 on all thyroid specimens submitted to the Pathology Department, Hospital Universiti
Sains Malaysia (HUSM), in Kelantan demonstrated that malignant thyroid lesions arising from multi-nodular
goitre are high in a population living in an iodine-deficiency area. The hospital-based incidence of all types ofmalignant thyroid cancers was 3.5 per 100,000, the majority being papillary carcinomas.
.
Asian Pacific J Cancer Prev,10, 87-90

Evaluation of Plasma Non-enzymatic Antioxidants in Breast
Cancer Etiology Franky D Shah, Jayendrakumar B Patel, Shilin N
Shukla, Pankaj M Shah, Prabhudas S Patel(mohabat@shirazu.ac.ir)

Mini-Abstract
Diet derived antioxidants play an important role against oxidative stress and the aim of the present study
was to examine roles of non-enzymatic antioxidants in breast cancer in India. Odds ratio analysis revealed that,
increasing levels of plasma beta-carotene, vitamin E and vitamin C were significantly associated with decreased
risk of breast cancer, whereas, increased risk was linked to plasma vitamin A . The trends of the current study
provide interesting clues to the etiology of breast cancer and suggest significance of interplay of non-enzymatic
antioxidants in breast cancer.
Asian Pacific J Cancer Prev, 10, 91-96

Risk Factors for Hepatitis B Infection in Rural Vietnam
Thai Hong Duong, Phuong Hong Nguyen, Keith Henley, Marion Peters(nhphuong68@yahoo.com)

Mini-Abstract
Hepatitis B virus (HBV) infection is a significant public health problem in Vietnam, yet few data exist about
the extent of infection or risk factors. In the present population-based epidemiological study, multivariate
analysis demonstrated five predictors for HBV infection: male gender, age greater than 40, Kinh ethnicity, a low
level of education, and a history of surgery. The observed high prevalence of current and past infection with
HBV in rural Vietnam highlights the need for close monitoring. Asian Pacific J Cancer Prev, 10, 97-102

Effects of Rhinacanthus nasutus Kurz on Colon Carcinogenesis
in Mice
Piengchai Kupradinun, Pongpun Siripong,
Rittichai Chanpai, Suratsawadee Piyaviriyagul,
Anudep Rungsipipat, Supradit Wangnaitham (pkupradi@health.moph.go.th)
Mini-Abstract
Rhinacanthus nasutus Kurz., a Thai medicinal plant which possess antiproliferative and pro-apoptotic effects
on human cancer cells, was examined for chemopreventive potential against colonic neoplasms induced byazoxymethane (AOM) combined with dextran sodium sulfate (DSS) in mice. Our results suggest that water
extract of the roots of R. nasutus Kurz. has no preventive potential against colon carcinogenesis induced by
AOM/DSS in mice, rather increasing the incidence of colonic tumors when given during initiation and promotion
phases. Further study on RNR should provide more information on mechanisms of its tumor promotion activity.
Asian Pacific J Cancer Prev, 10, 103-106
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

Burden of Hospitalization for Gastrointestinal Tract Cancer
Patients - Results from a Cross-sectional Study in Tehran
Mohamad Amin Pourhoseingholi, Mohsen Vahedi, Bijan MoghimiDehkordi*, Asma Pourhoseingholi, Fatemeh Ghafarnejad, Elham Maserat,
Azadeh Safaee, Babak Khoshkrood Mansoori, Mohammad Reza Zali
Mini-Abstract(b_moghimi_de@yahoo.com)

Gastrointestinal cancers are the most frequent neoplasms among Iranian males and second to breast cancer
among females. This study was designed as a retrospective cross-sectional survey included all consecutive GI
cancer patients admitted over a one year period in a randomly selected hospital group located in metropolitan
Tehran in 2006.The mean hospitalized durations were 7.5±6.5 days for men and 7.2±8.1 days for women. By
considering the hospitalized GI tract cancers and majority colorectal cancers, prevention programs like as CRC
screening should be promoted to reduce morbidity rates.
Asian Pacific J Cancer Prev, 10, 107-110

CYP17 (T-34C), CYP19 (Trp39Arg), and FGFR2 (C-906T)
Polymorphisms and the Risk of Breast Cancer in South Indian
Women Mani Samson, Ranganathan Rama, Rajaraman Swaminathan,
Veluswami Sridevi, Karunakaran Nirmala Nancy, Thangarajan Rajkumar
Mini-Abstract(rajkumart@yahoo.com)

Breast cancer is initiated by exposure to endogenous and exogenous estrogens. Genotyping was done using
the Taqman allelic discrimination assay for CYP17 (T-34C) and FGFR2 (T-906C) and PCR-CTPP for CYP19(Trp39Arg). In the present case-control study, There was a significant protective association of the (TT/CC)
genotype of the CYP17 gene against the risk of developing breast cancer, which was more significant inpostmenopausal women.
Asian Pacific J Cancer Prev, 10, 111-114

Is there any Clinical Advantage in Separating CIN 2 from CIN
3 in the Current Two-tiered Cytological Classification?
Sathone Boonlikit*, Nattinee Srisantiroj (sathone_b@yahoo.com)
Mini-Abstract
To investigate the practical use of description for CIN 2 or CIN 3 in HSIL cytology, the objective of thepresent study is to compare the prevalence of histologic CIN 2/3 or cancer (CIN 2+) between women with cytologic
CIN 2 and CIN 3. While the histologic outcome obviously differs between women with cytologic CIN 2 and CIN
3, the two groups should be managed similarly because of the high prevalence of high-grade cervical lesion
including invasive cancer.
Asian Pacific J Cancer Prev, 10, 115-118

Expression and Clinical Significance of Tbx2 in Pancreatic
CancerSong Duo, Tian Tiao-dong, Zhou Lei,Wang Wei, Sun Hong-li,
Mini-Abstract

Dai Xian-wei (sdhappy2009@hotmail.com)

TBX2 is one of the family of genes encoding developmental transcription factors, characterized by a 200
amino acid DNA binding domain (T-box), found to be related to malignant phenotypes of mammary cancer. The
present study was conducted to investigate the expression and clinical significance of TBX2 in pancreatic cancer.
The results suggest that Tbx2 protein might play an important role in the process of the development andmetastasis of pancreatic cancers and high-level Tbx2 expression might be related to malignant potential.
Asian Pacific J Cancer Prev, 10, 119-122
APJCP Vol 10., No 1

Asian Pacific Organization for Cancer Prevention and Control

Cancer Incidence Rates and the Problem of Denominators - a
New Approach in Indian Cancer Registries
Ramnath Takiar, B Shobana(ramnath_takiar@yahoomail.co.in)

Mini-Abstract
In India, the national census provides population figures once every 10 years. However, since cancer incidence
data provide various rates for five year age groups, the calculation of the relevant population estimates for agiven year between any two-census years, serving as denominators, assumes importance. We here show that the
proposed Difference Distribution Method is able to maintain both negative as well as positive growth in different
five yearly age group populations. For population projections, this method scores over the Individual Exponential
Growth Method, serving as a new methodology for population estimation by five yearly age groups for intercensus years for Indian cancer registries.
Asian Pacific J Cancer Prev, 10, 123-126

Glutathione S-Transferase Polymorphisms in Breast Cancersof Thai Patients Tanett Pongtheerat, Maneerut Treetrisool,
Wichai Purisa (dtanett@yahoo.com)
Mini-Abstract
Glutathione S-transferase (GST) enzymes involved in the detoxification of reactive metabolites of carcinogens
may be important in modulating susceptibility to cancers. This study aimed to determine the influence ofgenetic polymorphisms of glutathione S-transferase T1, M1, P1 and A1 on breast cancer in Thai patients. From
the results, GST genotypes may not be associated with susceptibility, a GSTP1 polymorphism(Ile105Val) may
be related to progression of breast cancer.
Asian Pacific J Cancer Prev, 10, 127-132

Breast Cancer Knowledge, Risk Factors and Screening Among
Adult Saudi Women in a Primary Health Care Setting
Mini-Abstract

Tarek Tawfik Amin, Abdul Rahman Saleh Al Mulhim,
Abdullalh Al Meqihwi (amin55@myway.com)

To assess level and determinants of knowledge about risk factors and utilization of screening methods used
for breast cancer early detection among adult Saudi women in Al Hassa, KSA, cross-sectional descriptive study
was performed.. Both descriptive and inferential statistics were applied; logistic regression was conducted todetermine the possible correlates of knowledge. Overall level of knowledge regarding risk factors and appropriate
screening was low and dependent upon educational and occupational status. Early screening is underutilized
among participants due to several perceived barriers.
Asian Pacific J Cancer Prev, 10, 133-138

E-flow Doppler Indices for Prediction of Benign and Malignant
Ovarian Tumors
Theera Tongsong*, Chanane Wanapirak, Vithida Neeyalavira,
Surapan Khunamornpong, Kornkanok Sukpan (ttongson@mail.med.cmu.ac.th)
Mini-Abstract
To determine the validity of pulsatility and resistance index of transabdominal Doppler ultrasound (e-flow)in distinguishing between benign and malignant adnexal masses, a cross-sectional descriptive study was conductedon patients scheduled for elective surgery due to adnexal masses at Maharaj Nakorn Chiang Mai Hospital,
Thailand, between April 2006 and March 2008. Pulsatility and resistance indices with transabdominal Doppler
ultrasound (e-flow) were thereby found to have high accuracy for differentiating between benign and malignant
adnexal masses.
Asian Pacific J Cancer Prev, 10, 139-142
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

Genistein Mechanisms and Timing of Prostate Cancer
Chemoprevention in Lobund-Wistar Rats
Jun Wang, Isam-Eldin Eltoum, Mark Carpenter, Coral A Lamartiniere(jun.wang@ccc.uab.edu)

Mini-Abstract

The objective of the present study was to determine if a specific window of development (neonatal/ prepubertal
only, adult only, or life-time) is effective for genistein chemoprevention of prostate cancer, and the potential
mechanisms of genistein chemoprevention in vivo. The incidence of advanced prostate cancer induced by NMU
in Lobund-Wistar rats was reduced during adult and life-time exposure, the latter being more effective. The
regulation of AR/Akt/PTEN axis by genistein may be one of the molecular mechanisms by which it inhibits cellproliferation and induces apoptosis, thus providing evidence of roles of genistein in prostate cancer prevention
and treatment.
Asian Pacific J Cancer Prev, 10, 143-150

Role of Heparanase-1 in Gastric Carcinoma Invasion
Xu Yingying, Zhang Yong, Wang Zhenning, Zhang Xue, Jiang Li,
Luo Yang, Xu Huimian (josieon826@yahoo.com.cn)
Mini-Abstract
The heparan sulfate–degrading endoglycosidase may mediate tumor invasion and metastasis. In this study
we investigated its potential role in gastric carcinoma malignant behaviour. The HPA-1 specific siRNA significantly
suppressed expression of heparanase-1 in SGC7901 cells. Invasion after RNAi treatment through membranes ina model system was significantly decreased. Thus, HPA-1 facilitates gastric carcinoma invasion by up-regulating
endoglycosidase activity in tumor cells.
Asian Pacific J Cancer Prev, 10, 151-154

Fine Needle Aspiration Biopsy, Core Needle Biopsy or Excision
Biopsy to Diagnose Breast Cancer - Which is the Ideal Method?
Teck-Meng Tham, Krishnan Rangaswamy Iyengar, Nur Aishah Taib,
Cheng- Har Yip (yipch@um.edu.my)

Mini-Abstract

The ideal method for diagnosis of breast cancer is debatable. To cast light on this problem, methods ofdiagnosis of 436 new cases of breast adenocarcinoma presenting from Jan 2005 till Dec 2006 at the University
Malaya Medical Centre (UMMC) were examined in this study. In the University Malaya Medical Centre (UMMC), FNAC was the commonest initial method (68.3%) compared to cases diagnosed outside UMMC, where 37.5%
of cases were diagnosed by excision. Tumours less than 2cm were more likely to be diagnosed by excision
biopsy.The biopsy method used to confirm the diagnosis is thus influenced by where the patient first presents,
and by the size of the tumour.
Asian Pacific J Cancer Prev, 10, 155-158

Establishment of an Integrated Management Model for theSecondary Prevention of Cervical Cancer - an Experience in
Taiwan Hospital
Yu-Hua Yan, Shuofen Hsu, Shih-Chieh Fang,
Chih-Ming Kung

(alex@mail.kh.usc.edu.tw)

Mini-Abstract
In the present study, secondary data analysis was utilized to evaluate the efficiency of the integrated
management model (IMM) on the Pap smear test for screening of women’s uterine cervical cancer. The data of
female patients receiving a Pap smear test were collected both before (from July to December, 2006) and after(from January to June, 2007) introducing the IMM in a regional hospital in Tainan. The result revealed anincrement of participation rate from 5.1% to 15.4% (p <0.001) among the female patients in the OPD (outpatient department), although the post-IMM participation rate was still much lower than that of general hospital
data in Taiwan.
Asian Pacific J Cancer Prev, 10, 159-162
APJCP Vol 10., No 1

Asian Pacific Organization for Cancer Prevention and Control

Uterine Malignancy following Tamoxifen Use in Breast Cancer
Patients in Iran: Case Series and Literature Review
Nadereh Behtash, Razieh Hashemi, Mojgan Karimi Zarchi (m49rahmani@yahoo.com)
Mini-Abstract
This study evaluated tumor characteristics and survival in women with breast cancer who subsequently
developed uterine cancer. Information about endometrial cancer in tamoxifen users following breast cancer
refered to the gynecologic oncology clinic of Vali-Asr hospital between 1997-2007 was evaluated. Our results
indicate that breast cancer patients who use tamoxifen and have early stage endometrial cancers demonstrate agood prognosis. Abnormal uterine bleeding or vaginal discharge is the most important symptom.
Asian Pacific J Cancer Prev, 10, 163-166

Epidemiology and Clinicopathology of Breast Cancer in Metro
Manila and Rizal Province, Philippines
Adriano Laudico, Maria Theresa M Redaniel, Maria Rica Mirasol-Lumague,
Cynthia A Mapua, Gemma B Uy, Eero Pukkala , Paola Pisani (yago_md@yahoo.com)
Mini-Abstract
The breast cancer incidence in the Philippines is among the highest in Asia. Age-standardized incidence
rates (ASR) in Metro Manila and Rizal Province derived from the Philippine Cancer Society-Manila Cancer
Registry and the Department of Health-Rizal Cancer Registry showed increase from 1980 to 2002, and weresignificantly higher in 7 cities in Metro Manila and significantly lower in 14 cities/municipalities mostly in Rizal
Province. The age-adjusted 5-year relative survival, using period analysis, of Metro Manila residents, FilipinoAmericans and Caucasians were 58.6%, 89.6% and 88.3% respectively.
Asian Pacific J Cancer Prev, 10, 167-172

Psychological and Social Adaptation of Women With Breast
Arzu Tuna Malak, Aysun Babacan Gümüs (aysungumus@gmail.com )CancerMini-Abstract
Breast cancer and the associated physical problems may cause people to experience different psychologicaland social adaptation processes. Nursing interventions can affect physical, psychological and social adaptationin such women and help to prevent and overcome depression and anxiety. It should be stressed that both physicaland psychosocial well-being enhance health and quality of life.
Asian Pacific J Cancer Prev, 10, 173-176

How to Search for Specific Markers of Cancer Stem Cells
Hai Guang Liu, Xiao Hua Zhang (zhangxhwzmc@yahoo.com)
Mini-Abstract
According to cancer stem cell hypothesis, cancer stem cells with unlimited self-renewal and multidifferentiation properties such as adult stem cells are the root cause of cancer initiation and progression, andtargeted therapy to cancer stem cells is to become the most efficient therapy of cancer. However, specific markers
should be discovered to define cancer stem cells accurately before targeted therapy. Therefore, we propose amodel of specific markers of cancer stem cells and how to search these markers.
Asian Pacific J Cancer Prev, 10, 177-180
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

CONFERENCES and WORKSHOPS
12th World Public Health Congress
Istanbul, Turkey, April-May 2009

UICC-ARO/APOCP South-East Asian Regional Workshop
Research Collaboration in South-East Asia, Kuala Lumpur, Malaysia, July 2009

UICC-ARO/APOCP Arab World Regional Workshop
Research Collaboration in the Arab World, Cairo, Egypt, August 2009

UICC-ARO/APOCP Central Asian Regional Workshop
Research Collaboration in Central Asia
Bishkek, Kyrgyzstan, September 2009

UICC-ARO/APOCP Pacific/Australasia Regional Workshop
Research Collaboration in the Pacific, Auckland, New Zealand, October 2009

3rd International Cancer Control Congress‘International Collaborations’Como, Italy, November 2009 www.cancercontrol2009.com

2nd Middle East and North Africa Cancer Research Conference
Amman, Jordan, November 2009

20th Asian Pacific Cancer Congress‘Cancer Control - Generating Unique Asian Pacific Contributions’Tsukuba, Japan, November 2009 www2.convention.jp/20th-apcc/

APOCP/UICC-ARO South Asian Regional Workshop
Research Collaboration in South Asia, Bangalore, India, December 2009

Fifth APOCP General Assembly
Conference‘Building Bridges for Cancer Control’
Istanbul, Turkey, April 2010

UICC World Cancer Congress
China, August 2010

APOCP Regional Meetings
Pakistan, Spring 2010
Korea, Autumn 2010

APJCP Vol 10., No 1

Asian Pacific Organization for Cancer Prevention and Control

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
INFORMATION FOR AUTHORSAPJCP Editorial Office. The editorial offices are located in Thailand and Japan but submission is all electronic.
Types of Manuscript.
Editorials
Commentaries

Reviews/Mini-reviews
Policy and Practice Reports

Research Communications
Letters to the Editor

Peer Review.
Manuscripts submitted to the APJCP are reviewed by two or more authorities for significance and validity andcomments are all supplied to the author. Advice as to acceptability will normally be supplied within one or twomonths.
Submission of Manuscripts.
Manuscripts can be submitted to Malcolm Moore at apocpcontrol@yahoo.com or any of the Subject Editors
listed inside the front cover. There are no submission or page charges. Please send a Microsoft Word file for text and a
Powerpoint file for figures. No hard copy is necessary except when a figure may be needed for scanning.
Conflict of Interest.
Information as to commercial or other links which might pose a conflict of interest should be provided. Funding
sources can be acknowledged in the Acknowledgements.
Permission for Inclusion of Published Material.
The authors have full responsibility for obtaining permission for inclusion of previously published material inwork submitted to the APJCP.
Organization of Manuscripts.
Title page: Concise title, authors names and affiliations, address for correspondence, Fax number, Email address
Abstract page: Concise abstract and key words
Text pages: Arranged as appropriate for the type of manuscript
References: In text cited as Yellow (2000), (Brown and Pink, 2000), (Black et al., 2000): NOT NUMBERED!
Earliest first, then chronologically and alphabetically
List: alphabetically then by year, all authors if up to five, three and et al for more.
Format:Brown A, Pink B, Black C, et al (2000). Cancer prevention in the Asian-Pacific. Asian Pac
J Cancer Prev, 8, 10-2.
Brown A, Pink B, Black C, et al (2000). Cancer prevention. In ‘Neoplasia’ , Eds Blue D
and Red E. Asian Pacific Education Press, Bangkok pp1-10
Illustrations: Should be of size and quality for direct downloading.
Proofs and Copyright.
Proofs will be sent as pdf files. Reprints can not be provided but the authors will be able to print out whatevercopies they need from the final pdf file. They retain copyright other than that necessary for publication in the APJCP.

INFORMATION FOR ANY INTERESTED IN BECOMING APOCPC MEMBERS
The quarterly electronic Asian Pacific Journal of Cancer Prevention (APJCP) is published by the Asian PacificOrganization for Cancer Prevention and Control with support from the UICC-Asian Regional Office for Cancer Control
to promote increased awareness and knowledge in all areas of cancer prevention/control and to stimulate collaborative
efforts and practical intervention approaches in the different countries and states of the Asian Pacific region. The
journal is indexed on PubMed and Science Citation Index Expanded and free pdf files can be downloaded from our
website www.apocp.org. There are no subscription charges and individual membership is free. If you wish to be belisted as a member and receive a quarterly pdf APJCP Contents and Mini-Abstracts please send an email with yourdetails to Malcolm Moore.
The APOCPC is a non-profit concern. Any donations and institutional membership charges (both listed in the
yearly report) are used to support meetings and training courses to help achieve the aims of cancer prevention/control
in the Asian Pacific region.
APJCP Vol 10, No 1

Asian Pacific Organization for Cancer Prevention and Control

CONTENTS APJCP Volume 10, Number 1, Jan-Feb 2009
EDITORIAL
What is the Future for the Asian Pacific Journal of Cancer Prevention (and Control) and the Asian PacificOrganization for Cancer Prevention (and Control)? Malcolm A Moore et al
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1

Cancer Epidemiology and Control in the Arab World - Past, Present and Future Elsayed I Salim et al .

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3

RESEARCH COMMUNICATIONS
Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan Keun Soo Ahn et al.

17

GSTM1, GSTT1 and CYP1A1 Polymorphisms and Risk of Oral Cancer: a Case-control Study in Jakarta,
Indonesia Rahmi Amtha et al
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REVIEW.

21

Human Papillomavirus Genotype Distribution in Cervical Cancer in India: Results from a Multi-center Study
Partha Basu et al
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27

Impact of Consanguinity on Cancer in a Highly Endogamous Population Abdulbari Bener et al .

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35

Rising Incidence of Gastric Malignancies in Karachi, 1995- 2002 Yasmin Bhurgri et al

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41

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45

Breast Cancer Screening Behavior in Turkish Women: Relationships with Health Beliefs and Self-esteem, Body
Perception and Hopelessness Olcay Çam and Aysun Babacan Gümüs
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49

Ethnic Disparities in Cancer Incidence among Residents of Guam Robert L Haddock et al

Incidence and Trends of Prostate Cancer in Karachi South, ‘1995- 2002’ Yasmin Bhurgri et al.

Efficacy and Toxicity of Gemcitabine and Pegylated Liposomal Doxorubicin in Recurrent PlatinumResistant/Refractory Epithelial Ovarian Cancer Aziz Karaoglu et al
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63

Estimating the Incidence of Leukemia Attributable to Occupational Exposure in Iran Alireza Mosavi-Jarrahi et al

67

Advantages of Second Line Estramustine for Overall Survival of Hormone-Refractory Prostate Cancer(HRPC) Patients Taku Naiki et al .
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Lifetime Risk and Trends in Lung Cancer Incidence in Greater Mumbai Namrata Agarwal et al

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Cooking Temperature, Heat-generated Carcinogens, and the Risk of Stomach and Colorectal Cancers
Le Tran Ngoan et al
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83

Spectrum of Thyroid Lesions in Hospital Universiti Sains Malaysia Over 11-Years and A Review of Thyroid
Cancers in Malaysia Nor Hayati Othman et al
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87

Evaluation of Plasma Non-enzymatic Antioxidants in Breast Cancer Etiology Franky D Shah et al

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91

Risk Factors for Hepatitis B Infection in Rural Vietnam Thai Hong Duong et al

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103

Burden of Hospitalization for Gastrointestinal Tract Cancer Patients - Results from a Cross-sectional Study in
Tehran Mohamad Amin Pourhoseingholi et al
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107

CYP17 (T-34C), CYP19 (Trp39Arg), and FGFR2 (C-906T) Polymorphisms and the Risk of Breast Cancer inSouth Indian Women
Mani Samson et al
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111

Effects of Rhinacanthus nasutus Kurz on Colon Carcinogenesis in Mice.

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Piengchai Kupradinun et al.

Is there any Clinical Advantage in Separating CIN 2 from CIN 3 in the Current Two-tiered CytologicalClassification? Sathone Boonlikit and Nattinee Srisantiroj .
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115

Expression and Clinical Significance of Tbx2 in Pancreatic Cancer Song Duo et al

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119

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Cancer Incidence Rates and the Problem of Denominators - a New Approach in Indian Cancer Registries
Ramnath Takiar and B Shobana
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Glutathione S-Transferase Polymorphisms in Breast Cancers of Thai Patients Tanett Pongtheerat et al .

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Breast Cancer Knowledge, Risk Factors and Screening Among Adult Saudi Women in a Primary Health Care Setting
Tarek Tawfik Amin et al
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133
E-flow Doppler Indices for Prediction of Benign and Malignant Ovarian Tumors Theera Tongsong et al.

139

Genistein Mechanisms and Timing of Prostate Cancer Chemoprevention in Lobund-Wistar Rats Jun Wang et al

143

Role of Heparanase-1 in Gastric Carcinoma Invasion Xu Yingying et al.

151

Fine Needle Aspiration Biopsy, Core Needle Biopsy or Excision Biopsy to Diagnose Breast Cancer - Whichis the Ideal Method? Teck-Meng Tham et al
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155

Establishment of an Integrated Management Model for the Secondary Prevention of Cervical Canceran Experience in Taiwan Hospital Yu-Hua Yan et al .
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159

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Uterine Malignancy following Tamoxifen Use in Breast Cancer Patients in Iran: Case Series and Literature Review
Nadereh Behtash et al .
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COMMENTARIES
Epidemiology and Clinicopathology of Breast Cancer in Metro Manila and Rizal Province, Philippines
Adriano Laudico et al
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167

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Psychological and Social Adaptation of Women With Breast Cancer Arzu Tuna Malak and Aysun Babacan Gümüs

173

How to Search for Specific Markers of Cancer Stem Cells Hai Guang Liu and Xiao Hua Zhang
APJCP Vol 10., No 1

177.

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