氏名

所属

職名

取得学位

専門分野

主な論文・著作・業績①: Furuyama K. and Sassa S.. Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme
ALAS-E is disrupted in sideroblastic anemia. J Clin Invest. 2000;105:757-64.
②: Furuyama K. and Yamamoto M. Differential regulation of 5-aminolevulinate synthase isozymes in vertebrates.
Ferreira GC, Kadish KM, Smith KM, Guilard R edited, Handbook of Porphyrin Science, Vol. 27, p.2-41, 2013

古山

和道

生化学講座
分子医化学分野

医化学関連

教授

博士(医学)

病態医化学関連
分子生物学関連③: Kaneko K., Furuyama K., Fujiwara T., Kobayashi R., Ishida H., Harigae H., Shibahara S. Identification of thenovel erythroid-specific enhancer for ALAS2 gene and its loss-of-function mutation associated with congenitalsideroblastic anemia. Haematologica. 2014;99:252-261④: Kubota Y, Nomura K, Katoh Y, Yamashita R.,Kaneko K., Furuyama K. Novel Mechanisms for Heme-dependent
Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. J BiolChem. 2016;291(39): 20516-20529.
⑤: 文部科学省科学研究費補助金

基盤研究C「課題名：環状鉄芽球における細胞死のメカニズムの解明（課題番号21K06874）」2021年−2023年①:Kubota, Y., A. Shimada and A. Shima. 1995. DNA alterations detected in the progeny of paternally irradiatedJapanese medaka fish (Oryzias latipes). Proc. Natl. Acad. Sci. USA. 92. 330-334.
②: Kubota Y., Nash RA, Klungland A, Schar P, Barnes DE, Lindahl T. 1996. Reconstitution of DNA base excisionrepair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J.
15(23):6662-70.

久保田美子

生化学講座
分子医化学分野

准教授

修士(理学)

分子生物学関連③: Kubota, Y., Takanami, T., Higashitani, A. and Horiuchi, S. 2009. Localization of X-ray Cross Complementing

博士(理学)

機能生物化学関連

Gene 1 Protein in The Nuclear Matrix is Controlled by Casein Kinase II-dependent Phosphorylation in Response to博士(医学)

医化学関連

Oxidative Damage. DNA Repair, 8, 953-960.
④:Kubota,Y., Shimizu,S., Yasuhira, S., Horiuchi, S. 2016. SNF2H interacts with XRCC1 and is involved in repair ofH2O2-induced DNA damage. DNA Repair, 43,69–77.
⑤: Kubota Y, Nomura K, Katoh Y, Yamashita R.,Kaneko K., Furuyama K. 2016. Novel Mechanisms for Hemedependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme
Biosynthesis. J Biol Chem. 291(39), 20516-20529.
①: Kaneko K, Furuyama K, Aburatani K, Shibahara S. Hypoxia induceserythroid-specific 5-aminolevulinate
2009;276:1270-82.
②: Kaneko K, Furuyama K, Fujiwara T, Kobayashi R, Ishida H, Harigae H, Shibahara S. Identification of the novel
erythroid-specific enhancerfor ALAS2 heme and its loss-of-function mutation associated with congenitalsideroblastic anemia. Haematologica 2014; 99: 252-61.

金子桐子

生化学講座
分子医化学分野

講師

修士(医学)

分子生物学関連③: Kubota Y, Nomura K, Katoh Y, Yamashita R.,Kaneko K., Furuyama K. Novel Mechanisms for Heme-dependent

博士(医学)

細胞生物学関連

Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis. J Biol
Chem. 2016;291:20516-20529.
④: Kaneko K, Kubota Y, Nomura K, Hayashimoto H, Chida T, Yoshino N, Wayama M, Ogasawara K, Nakamura Y,Tooyama I, Furuyama K. Establishment of a cell model of X-linked sideroblastic anemia using genome editing. ExpHematol. 2018;65:57-68⑤: 文部科学省科学研究費補助金

基盤C「課題名：鉄芽球性貧血モデル細胞を用いたミトコンドリア鉄蓄積機構の解析」（研究課題番号：21K08375）2021-2023

①: Sato K, Minegishi S, Takano J, Plattner F, Saito T, Asada A, Kawahara H, Iwata N, Saido TC., Hisanaga S,Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
Journal of Neurochemistry 117(3) 504-515 2011②: 文部科学省科学研究費補助金

若手研究(B)「課題名：分子コシャペロンFKBP5による神経細胞内凝集機構の解明(研究課題番号：26870846)」 2014年度～2016年度

鈴木亘

生化学講座
分子医化学分野

助教

博士（理学）機能生物化学関連③: Taoka M, Nobe Y, Yamaki Y, Sato K, Ishikawa H, Izumikawa K, Yamauchi Y, Hirota K, Nakayama H, Takahashi N,

病態医化学関連

Isobe T, Landscape of the complete RNA chemical modifications in the human 80S ribosome. Nucleic Acids

神経科学一般関連

Research Vol.46 No.18 9289-9298 2018④: Kamal MM, Ishikawa S, Takahashi F, Suzuki K, Kamo M, Umezawa M, Shinozaki K, Kawamura Y, Uemura M,
Large-Scale Phosphoproteomic Study of Arabidopsis Membrane Proteins Reveals Early Signaling Events inResponse to Cold. Int. J. Mol. Sci. 2020, 21(22), 8631; https://doi.org/10.3390/ijms21228631⑤: 鈴木亘、Costantine Chasama Kamata、古山和道

質量分析による赤芽球特異的5-アミノレブリン酸合成酵素複合体タンパク質の解析 岩手医学雑誌 2023, 75 (2), 69-79①: Yonehara K, Zhou Y, Takahashi JI, Yokoyama S, Tomihara K, Noguchi M, Sakurai H, RSK-Mediated Noncanonical Activation of EphA2 by Tamoxifen. Biol Pharm Bull. 2022, 45(2), 162-168②: Haryuni RD, Tanaka T, Takahashi JI, Onuma I, Zhou Y, Yokoyama S, Sakurai H, Temozolomide Induces
Endocytosis of EGFRvIII via p38-Mediated Non-canonical Phosphorylation in Glioblastoma Cells. Biol Pharm Bull.

高橋隼一郎

生化学講座

助教

分子医化学分野（任期付）

博士（薬学）

分子生物学関連

2021, 44(11), 1681-1687

細胞生物学関連③: Takahashi JI, Nakamura S, Onuma I, Zhou Y, Yokoyama S, Sakurai H, Synchronous intracellular delivery of
EGFR-targeted antibody-drug conjugates by p38-mediated non-canonical endocytosis. Sci Rep. 2022, 12(1), 11561④: Yamagishi N, Takahashi JI, Zhou Y, Yokoyama S, Makino T, Shimizu T, Sakurai H, Non-canonical regulation ofEGFR by the air pollutant 9,10-phenanthrenequinone. Biol Pharm Bull. 2022, 45(10), 1553-1558