The 4th Annual Meeting of JSIT
1997.9.30-10.1.
Toho Seimei Hall （Tokyo）
President: Michihito TAKAHASHI (National Institute of Health Sciences)
Special Invited Lecture
Chemical-and drug-induced
autoimmunity and its
mechanisms: what do T cells
recognize in adverse
immunec reactions tochemicals?

E. Gleichmann, T.
Pape, M. Wulferink,
P. Griem

Division of Immunology,
Medical Institute ofEnvironmental Hygiene at
Heinrich Heine University

Special Lecture
Cytokines in diseases: newapproaches to clinical use

S. AsanoInstitute of Medical Science,
University of Tokyo

Symposium
Problems on the drug-induced
M. Muranakaanaphylactic reactions
Delayed drug allergy, especially, action mechanismof drug allergens in allergic
eruptions induced by Oxicam

Z. Ikezawa

derivativesFood allergy
Working environment andallergy: a lesson from study
on hard metal disease

S. Kaminogawa

Y. Kusaka

Yugawara Kosei-nenkin Hospital

Urafune Hospital, Dept. ofDermatology, Yokohama City
Uni. School of Medicine
Dept.of Applied Biological
Chemistry, The University ofTokyo
Department of Environmental
Health, School of medicine,
Fukui Medical UniversityWorkshop
International trend on
immunotoxicity testing
guidelines in experimental
K. Mitsumori
animals: Immunopathologicalexaminations

Division of Pathology, National
Institute of Health Sciences

Current topics in functional
immunotoxicity testing
guidelines

Division of Biochemistry andImmunochemistry, National
Institute of Health Sciences

J. Sawada

Practice and the point at issueof antigenicity study using
E. Makiguinea pigs
Investigations of allergenicity
test in mice
General Presentation

K. Shinkai, T. Aida,
N. Ishikawa, T.
KimuraPreclinical Development Dept.,
Research & Development
Division, Janssen-Kyowa, Co.,
Ltd./JPMA
Laboratory Animal Science &Toxicology Laboratories,
Sankyo Co., Ltd.

Differences in immuneresponses to low-molecular

T. Aida, N. Ishikawa,compounds in three guinea-K. Shinkai

pig strains

Laboratory Animal Science &Toxicology Laboratories,
Sankyo Co., Ltd.

Histopathological differences
between Arthus and delayed-

T. Kimura, T. Aida, I. Laboratory Animal Science &type hypersensitivity

Igarashi, N.

reactions to a low-molecular

Ishikawa, K. Shinkai Sankyo Co., Ltd.

Toxicology Laboratories,

compound in guinea-pigs
Investigation of antigeninity
study methods in guinea pigs
A prediction of chemicalinduced immunogenicity using
popliteal lymph node assay

K. Nagami, Y.

Development Research

Kawashima, H.

Laboratories, Banyu

Kuno, H. Matsumoto Pharmaceutical Co., Ltd.
Y. Kouchi, Y. Maeda,
A. Ohuchida

Drug Safety ResearchLaboratory, Taiho
Pharmaceutical Co., Ltd.

An attempt of development ofK. Ebino(1),a murine model for TDI
J.A.Kramarik(2),asthma through an
M.H. Karol(2)intratracheal administration(1)Dept. of Toxicology, Instituteof Environmental Toxicology,(2)Dept. of Environmental andOccupational Health, Universityof Pittsburgh

Investigation of antigenicity
screening methods with an
in-vitro systemT. Inoue, K.
Shimura, I. Horii

Dept. of Toxicology andPathology, Nippon Roche
Research Center

Development of an ELISA for
measurement of specificantibodies to a humanizedmonoclonal antibody

J. Soejima, S.
Mochizuki, N.
Tsutsui, H. Inoue

Toxicology Laboratory,
Yokohama Research Center,
Mitsubishi Chemical Corporation

Effects of carrot juice on theproduction of IgE and IgG
antibody in mice

H. Akiyama(1), K.
Hoshino(1), R.
Teshima(2), Y.
Goda(1), J.
Sawada(2), M.
Toyoda(1)(1)Div. of Foods , (2)Div. ofBiocheminstry andImmunochemistry, National
Institute of Health Sciences

Effencts of some antioxidants
and vanadate on TNF- α
production of RBL-2H3 cells

R. Teshima, J.
Onose, J. Sawada

Div. of Biochemistry andImmunochemistry, National
Institute of Health Sciences

Ozone exposure inhibits
contact hypersensitivity
responses in mice

H. Ushio, H.
Fujimaki

Environmental Health Science
Div. National Institute forEnvironmental Health Studies

The rat strain differences in
the immunotoxicologicalparameters

Y. Kanazawa(1),T.
Adachi(2),M.
Furuya(2),K.
Kojima(1,2)(1)Lab. of Immunotoxicol.,(2)Bio. Chem., Hatano Res.
Inst., Food and Drug Safety
CenterM. Nagata, M. Hino,
Effects of antigen stimulation
S. Kimura, A.
on the splenic lymphocyte
Watanabe, M.
subsets of cyclophosphamideTakeuchi, K.
treated rats
Nakamura
Evaluation of immunotoxicity
tests using dexamethasone
and cyclosporin A-III

M. Inoue, R.
Nagatahira, K.
Mochizuki, Y. Ito, J.
Yoshida, K. Saitoh

Developmental ResearchLaboratories, Shionogi & Co.,
Ltd.

Safety Research Laboratories
Kaken Pharmaceutical Co., Ltd.

T. Tamura, K.
Effects of Pyridine-Toyoda, T. Shoda, C.

Uneyama, K.
triphenylborane on the tissues
Mitsumori, K.
of immune system in rats
Takada, M.

Division of Pathology, NationalInstitute of Health Sciences

TakahashiRole of nitric oxide in cocaininduced immunosuppression

K. Aoki, R.
Kuwabara, T.
YoshidaDept. of Biochemical
Toxicology, School of
Pharmaceutical Sciences,
Showa University

Inhibitory effects of Chinese
medicine extracts onleukocyte apoptosis andimmunotoxicity induced bydoxorubicin

N. Toma, S.
Toyoshima

Department of Biochemistry,
Faculty of PharmaceuticalSciences, Hoshi University

Restraint stress effect and its J. Kanno(1,2),A.
modification by high vitamin- Wakikawa(2),M.
E intake on immune system in Utsuyama(2),K.
young and aged mice
Hirokawa(2)(1)Division of Cellular andMolecular Toxicology, National
Institute of Health Sciences,(2)Department of Pathology
and Immunology, School ofMedicine, Tokyo Medical andDental University

Immunomodulating effects of T. Yoshida(1),T.
electromagnetic field
Hagino(1),F.
exposure
Kayama(2)(1)Dept. of Environmental
Health, Tokai University, Schoolof Medicine, (2)Dept. ofHygiene, Jichi Medical College

Preventive medical study onstress reactions after theGreat Hanshin-Awaji
Earthquake. Part 13. The
association of lifestyle andPTSD-like symptoms withnatural killer cell activity

Department of Social and
C. Sakurai, S.
Environmental Medicine, OsakaMaruyama, S.
University Graduate School ofFukuda, K. Morimoto
Medicine

Ovariectomy induces
enhanced production ofproinflammatory cytokines
from liver, kidney and bonemarrow cells

F. Kayama, K.
Nakatsuka

Department of Environmental
Health, Jichi Medical School(1)Dept.of Microbiology, Saga
Medical School, (2)Dept. ofAugmentation of autoimmune S. Yoshino(1),M.
arthritis by diesel exhaust
Ohsawa(2),M.
particles
Sagai(3)Environmental Toxicology,
Faculty of PharmaceuticalSciences, Teikyo University,(3)Research Team for Health
Effects of Air Polutions, Nat.
Inst. for Environmental Studies,

Dysregulation of Fas/Fas
ligand system in apoptosis

T. Otsuki, A.

mechanisms for acquisition of Tomokuni, T.
autoimmunity in cases withAikoh,A. Ueki
silicosis

Dept. Hygiene, Kawasaki Med.
Sch.