The 56th Japanese Peptide Symposium
October 23 (Wednesday)
9:00–9:15

Opening Remarks (Hirokazu Tamamura)

9:15–10:21

Young Investigator's Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 1 (chairs: Shugo Tsuda, Yuya Asahina)

Y-01

Evaluation of the proteolytic activity of 5-mer peptides in BoxA region of Tob/BTG family proteins
against Amyloid-β fragment peptides
Rina Nakamura1,2, Motomi Konishi3, Yusuke Harakawa4, Toshiyasu Sakane4, Saito Motoaki2, Toshifumi
Akizawa1,2 (1O-Force Co., Ltd., 2Laboratory of Pharmacology, School of Medicine, Kochi University,
Laboratory of Clinical Analytical Chemistry, Faculty of Pharmaceutical Sciences, Setsunan University,

3

Pharmaceutical Technology, Kobe Pharmaceutical University)

4

Y-02

(Z)-Chloroalkene dipeptide isostere can mimic intraresidue hydrogen bonding interaction
Yuki Kodama1, Takuma Nishizawa2, Kohei Sato2, Nobuyuki Mase1,2, Tetsuo Narumi1,2 (1Graduate
School of Science and Technology, Shizuoka University, 2Graduate School of Integrated Science andTechnology, Shizuoka University)

Y-03

Synthetic study for novel Foxo3a inhibitor JBIR-141
Kotaro Yasoshima1, Masahito Yoshida2, Teppei Kawahara3, Kazuo Shin-ya3, Takayuki Doi1 (1Graduate
School of Pharmaceutical Sciences, Tohoku University, 2Department of Chemistry, University ofTsukuba, 3National Institute of Advanced Industrial Sciences and Technology)

Y-04

New detection method for peptide N-terminus on resin using N-hydroxyphthalimide derivatives
Rio Suzuki, Miku Kasai, Hiroyuki Konno (Department of Biochemical Engineering, Graduate School ofScience and Engineering, Yamagata University)

Y-05

Chemical synthesis of linker histone H1.2 using one-pot multiple peptide ligation with Ru catalyst
Naoki Kamo1, Gosuke Hayashi2, Tomoya Kujirai3, Hitoshi Kurumizaka3,4, Akimitsu Okamoto1,5(1Department of Chemistry and Biotechnology, Graduate School of Engineering, The University ofTokyo, 2Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University,
Laboratory of Chromatin Structure and Function, Institute for Quantitative Biosciences, The University

3of Tokyo, 4Department of Biological Sciences, Graduate School of Sciences, The University of Tokyo,
Research Center for Advanced Science and Technology, The University of Tokyo)

5Y-06

Structure revision of cyclic depsipeptide MA026 and structure-activity relationship study based ontight junction open activity
Chihiro Uchiyama1, Akane Fukuda1, Minagi Mukaiyama2, Yoshiki Nakazawa1, Mitsue Arimoto2,Koichiro Kako2, Akihiro Taguchi1, Kentaro Takayama1, Atsuhiko Taniguchi1, Yoko Nagumo2, Takeo
Usui2, Yoshio Hayashi1 (1Department of Medicinal Chemistry, School of Pharmacy, Tokyo University ofPharmacy and Life Sciences, 2Graduate School of Life and Environmental Sciences, University ofTsukuba)

10:21–10:40 Break(1)10:40–11:46 Young Investigator's Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 2 (chairs: Kazuya Kobayashi, Yoshiyuki Manabe)
Y-07

Design and synthesis of novel helical foldamers based on cyclopropane Δ-amino acids
Makoto Nagata1, Kou Takeuchi2, Ryohei Doi1, Tomoshi Kameda2, Koichi Fujiwara1, Yoshihiro Sato1,Mizuki Watanabe1,3, Satoshi Shuto1 (1Faculty of Pharmaceutical Sciences, Hokkaido University,
National Institute of Advanced Industrial Science and Technology, 3AMED)

2

Y-08

Development of blood-brain barrier permeable oxygenation catalyst of amyloid βNozomu Nagashima1, Shuta Ozawa2, Yukiko Hori2, Taisuke Tomita2, Youhei Sohma1, Motomu Kanai1(1Synthetic Organic Chemistry Lab., Graduate School of Pharmaceutical Sciences, The University ofTokyo, 2Neuropathology and Neuroscience Lab., Graduate School of Pharmaceutical Sciences, TheUniversity of Tokyo)

Y-09

Unnatural MUC1 based glycopeptides in new cancer biomarkers discovery
Pablo A. Guillen Poza1, Elena M. Sánchez Fernández2, José M. García Fernández2, Carmen Ortiz Mellet2,
Hiroshi Hinou1, Shin-Ichiro Nishimura1, Fayna Garcia-Martin1 (1Graduate School of Life Science,
Hokkaido University, 2Dept. Organic Chemistry, Faculty of Chemistry, University of Seville)

Y-10

Octaarginine-drug complexes for drug delivery to microbes and enhanced potency
Poonam Ratrey, Bhaskar Datta, Sameer V. Dalvi, Abhijit Mishra (Indian Institute of TechnologyGandhinagar)

Y-11

Laminin-alpha2 chain derived peptide enable enhanced delivery of plasmid DNA to skeltal muscle cells
Kei Nirasawa, Keisuke Hamada, Yukiko Naraki, Fumihiko Katagiri, Yoko Takahashi, Yamato Kikkawa,
Motoyoshi Nomizu, Yoichi Negishi (Graduate School of Pharmacy, Tokyo University of Pharmacy andLife Sciences)

Y-12

Development of antibody-tagged boron compounds using Fc-binding peptide for on-demand receptor
target in boron neutron capture therapy
Ayako Aoki1, Yuriko Sakai1,2, Yoshihide Hattori2, Mitsunori Kirihata2, Ikuhiko Nakase1 (1Department ofBiological Science, Graduate School of Science, Osaka Prefecture University, 2Research Center for
Boron Neutron Capture Therapy, Osaka Prefecture University)

11:46–12:00 Break
12:00–12:50 Luncheon Seminar
12:50–13:15 Break
13:15–14:21 Young Investigator's Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 3 (chairs: Kentaro Takayama, Kohei Sato)
Y-13

Functional study of polytheonamide mimic, an artificial ion-channel-forming peptide
Yun-Wei Xue, Atsushi Hayata, Hiroaki Itoh, Masayuki Inoue (Graduate School of PharmaceuticalSciences, The University of Tokyo)

Y-14

Intracellular delivery of bioactive molecules via macropinocytosis induction
Jan Vincent V. Arafiles, Hisaaki Hirose, Misao Akishiba, Shiroh Futaki (Institute for Chemical Research,Kyoto University)

(2)

Y-15

Synthesis and immunological evaluation of self-assembling CH401 epitope peptide and adjuvant as
anti-breast cancer vaccine candidate
Taku Aiga1, Yoshiyuki Manabe1,2, Kazuya Kabayama1,2, Shino Ohshima3, Yoshie Kametani3, Koichi
Fukase1,2 (1Graduate School of Science, Osaka University, 2Project Research Center for Fundamental
Sciences, Osaka University, 3School of Medicine, Tokai University)

Y-16

Artificial protein assembly in living cell by using a designed amphiphilic Yn peptide
Takayuki Miki, Taichi Nakai, Masahiro Hashimoto, Hiroshi Tsutsumi, Hisakazu Mihara (School of Life
Science and Technology, Tokyo Institute of Technology)

Y-17

Development of a novel coiled-coil labeling method for heterooligomer detection
Jun Takano, Yoshiaki Yano, Katsumi Matsuzaki (Graduate School of Pharmaceutical Sciences, KyotoUniversity)

Y-18

Cytosolic antibody delivery by IgG-binding L17E analogue
Takahiro Iwata, Misao Akishiba, Kentarou Sakamoto, Hisaaki Hirose, Shiroh Futaki (Institute for
Chemical Research, Kyoto University)

14:21–14:36 Break
14:36–15:42 Young Investigator's Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 4 (chairs: Kenichi Kawano, Rui Kamada)
Y-19

Development of ATP-binding protein inhibitor by two-step screening
Kazuto Mochizuki1, Yuji Ito2, Masumi Taki1 (1Department of Engineering Science, The Graduate Schoolof Informatics and Engineering, The University of Electro-Communications (UEC), 2Department ofChemistry and Bioscience, Graduate School of Science and Engineering, Kagoshima University)

Y-20

Peptide precursors that acquire collagen-hybridizing ability via O-to-N acyl migration
Sayaka Kanai1, Takaki Koide1,2 (1Department of Chemistry and Biochemistry, School of Advanced
Science and Engineering, Waseda University, 2Waseda Research Institute for Science and Engineering,
Waseda University)

Y-21

Characterization of elastin-like polypeptide-laminin α1 chain peptide in cell adhesion and spreading
Anh Tan Truong1,2, Keisuke Hamada2, Yuji Yamada2, Hao Guo1, Yamato Kikkawa2, Curtis Toshio
Okamoto1, John Andrew MacKay1, Motoyoshi Nomizu2 (1Pharmacology and Pharmaceutical Sciences,
School of Pharmacy, University of Southern California, 2Laboratory of Clinical Biochemistry, School ofPharmacy, Tokyo University of Pharmacy and Life Sciences)

Y-22

Development of inhibitors for intracellular protein-protein interactions using peptoids with alanyl
backbones
Yasuhiro Fukuda1, Jumpei Morimoto1, Daisuke Kuroda1,2,3, Satoru Nagatoishi4, Kohei Tumoto1,2,3,4,
Shinsuke Sando1,2 (1Department of Chemistry and Biotechnology, Graduate School of Engineering, TheUniversity of Tokyo, 2Department of Bioengineering, Graduate School of Engineering, The University ofTokyo, 3Medical Device Development and Regulation Research Center, School of Engineering, The
University of Tokyo, 4Institute of Medical Science, The University of Tokyo)

(3)

Y-23

Development of aptamer based stimuli-responsive PPM1D inhibitors with cell-penetrating activity
Atsushi Kaneko1, Miyuu Watari1, Masataka Mizunuma1, Hikaru Saitoh1, Kazuhiro Furukawa2, Yoshiro
Chuman1 (1Laboratory of Biological Chemistry, Department of Chemistry, Faculty of Science, Niigata
University, 2Cell Regulation Laboratory in Biochemistry, Department of Chemistry, Faculty of Science,Niigata University)

Y-24

Atrial natriuretic peptide may be responsible for bioactivities of geniposidic acid on spontaneously
hypertensive rat
Shohei Yamaguchi1, Ryuto Takahashi2, Nao Sugiman3, Tetsuya Hirata3, Yasuyo Yamaguchi3, Hiroo
Yamasaki3, Naoto Minamino4, Kozo Nakamura2,5 (1Department of Science and Technology, Graduate
School of Medicine, Science and Technology, Shinshu University, 2Department of Agriculture, Graduate
School of Science and Technology, Shinshu University, 3R&D Center, Kobayashi Pharmaceutical Co.,
Ltd., 4Omics Research Center, National Cerebral and Cardiovascular Center, 5Institute of Agriculture,
Academic Assembly, Shinshu University)

15:42–16:00 Break
16:00–17:15 Invited Lectures (20 min talk, 5 min discussion & exchange)(chair: Tetsuo Narumi)
K-1

Discovery of twisted imides on guanidines
Yan Lee (Department of Chemistry, College of Natural Sciences, Seoul National University)(chair: Hironobu Hojo)

K-2

Recent development in targeting polo box domain of polo like kinase 1 for anticancer therapy
Jeong Kyu Bang, Pethaiah Gunasekaran (Division of Magnetic Resonance, Korea Basic ScienceInstitute)(chair: Shiroh Futaki)

I-1

Peptidomimetics inhibitors of multifaceted toxicity in alzheimer’s disease
T. Govindaraju (Bioorganic Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre forAdvanced Scientific Research (JNCASR))

17:15–17:30 Break
17:30–19:00 Poster Presentations ① (P-001–P-055)(4)

October 24 (Thursday)
9:00–10:40

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 1 (chairs: Hiroyuki Konno, Toru Kawakami)

O-01

Development of the direct asymmetric indolylation of imino peptide for synthesis of indolylglycinecontaining peptide
Tsubasa Inokuma, Kana Masui, Kodai Nishida, Akira Shigenaga, Akira Otaka, Ken-ichi Yamada(Institute of Biomedical Sciences and Graduate School of Pharmaceutical Sciences, TokushimaUniversity)

O-02

Study of glycopeptide synthesis for development general method under microwave irradiation at lowtemperatures
Izuru Nagashima1, Takayuki Yokoe1, Yuuta Ohki2, Naoyuki Takahashi2, Hiroki Shimizu1 (1Life Scienceand Biotechnology, National Institute of Advanced Industrial Science and Technology (AIST), 2Tokyo
Rikakikai Co., Ltd)

O-03

Structure-based design of alpha-helix mimetics for disrupting estrogen receptor-coregulator
interactions in breast cancer
Jung-Mo Ahn (Department of Chemistry and Biochemistry, University of Texas at Dallas)

O-04

NMR analysis of hydrogen bonds in PF1171F, a cyclic hexapeptide with insecticidal activity, underpseudo body’s internal environment
Yuichi Masuda1, Moeka Sano1, Masaya Honda1, Ken-ichi Akagi2 (1Graduate School of Bioresources,
Mie University, 2National Institute of Biomedical Innovation, Health and Nutrition)

O-05

Development of cell-penetrating foldamers for delivery of biomacromolecules
Takashi Misawa1, Nobumichi Ohoka1, Makoto Oba2, Masakazu Tanaka2, Mikihiko Naito1, YosukeDemizu1,3 (1National Institute of health sciences, 2Graduate School of Biomedical Sciences, Nagasaki
University, 3Graduate of school of Medical Life Sciences, Yokohama city University)

10:40–11:00 Break
11:00–11:50 Special Lecture(chair: Hirokazu Tamamura)
Development of antiviral therapy of HIV infection: from AZT to darunavir and beyond
Hiroaki Mitsuya1,2 (1National Center for Global Health & Medicine Research Institute, 2Center for
Cancer Research, National Cancer Institute, National Institutes of Health)11:50–12:00 Break
12:00–12:50 Luncheon Seminar
12:50–13:00 Break
13:00–14:00 The Japanese Peptide Society General Meeting(5)

14:00–14:10 Break
14:10–15:30 Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 2 (chairs: Kazuyasu Sakaguchi, Masakazu Tanaka)
O-06

Concentration dependent coacervation property of nonlinear elastin-derived peptide (FPGVG)nanalogs
Keitaro Suyama1, Mika Mawatari2, Daiki Tatsubo2, Iori Maeda3, Takeru Nose1,2 (1Faculty of Arts andScience, Kyushu University, 2Department of Chemistry, Faculty and Graduate School of Science,
Kyushu University,

Department of Physics and Information Technology, Kyushu Institute of3Technology)
O-07

One-pot saturation mutagenesis of substrate peptides of posttranslationally modifying enzymes
Yuki Goto, Haruka Takeue, Yamato Komatsu, Alexander A. Vinogradov, Hiroaki Suga (Department ofChemistry, Graduate School of Science, The University of Tokyo)

O-08

Light-induced condensation of cell-penetrating peptides around targeted living cells to accelerate
membrane penetration
Ikuhiko Nakase1,2,3, Moe Miyai2,3, Kosuke Noguchi1,2,3, Mamoru Tamura2,3, Yasuyuki Yamamoto2,3,Yushi Nishimura2,3,4, Shiroh Futaki5, Shiho Tokonami3,6, Takuya Iida2,3 (1NanoSquare Research Institute,Osaka Prefecture University, 2Graduate School of Science, Osaka Prefecture University, 3ResearchInstitute for Light-induced Acceleration System (RILACS), Osaka Prefecture University, 4Division ofMolecular Materials Science, Graduate School of Science, Osaka City University, 5Institute for Chemical
Research, Kyoto University, 6Graduate School of Engineering, Osaka Prefecture University)

O-09

Analysis of anti-cancer mechanism of the soybean peptide, lunasin
Kilico Iida1, Yuriha Suzuki2, Miaomiao Sui2, Yukie Katayama2, Mimin Zhang2, Ken Okamoto2, MichioSuzuki2, Takahito Nakura2, Fumihiko Hakuno2, Naoyuki Kataoka2, Shin-ichiro Takahashi2, Hiroshi
Kawakami1, Koji Nagata2 (1Graduate School of Food Science and Nutrition, Kyoritsu Women’s
University, 2Graduate School of Agricultural and Life Sciences, The University of Tokyo)

15:30–15:45 Break
15:45–17:00 Invited Lectures (20 min talk, 5 min discussion & exchange)(chair: Yoshio Hayashi)
I-2

Electrochemical tryptophan-selective bioconjugation of proteins
Kounosuke Oisaki1, Eisho Toyama1, Katsuya Maruyama1, Tomoya Sugai2, Mio Kondo3, Shigeyuki
Masaoka3, Tsuyoshi Saitoh2, Motomu Kanai1 (1Graduate School of Pharmaceutical Sciences, The
University of Tokyo, 2International Institute for Integrative Sleep Medicine (WPI-IIIS), University ofTsukuba, 3Institute for molecular Science, National Institutes of Natural Sciences)(chair: Youhei Sohma)

I-3

Site-selective antibody modification using radical-mediated tyrosine click reaction
Shinichi Sato1, Michihiko Tsushima1,2, Keita Nakane1,2, Hiroyuki Nakamura1 (1Laboratory for Chemistry
and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 2School of Life
Science and Technology, Tokyo Institute of Technology)(chair: Akira Otaka)

(6)

I-4

Chemical tools for selective recognition of posttranslational modifications
Monika Raj (Department of Chemistry and Biochemistry, Auburn University)

17:00–17:15 Break
17:15–18:45 Poster Presentations ② (P-101–P-154)
19:00–21:00 Banquet (M&D Tower 26F, Faculty Lounge)(7)

October 25 (Friday)
9:00–10:20

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 3 (chairs: Shinya Oishi, Akira Shigenaga)

O-10

Inactivation of myostatin using peptide functionalized by photooxygenation catalyst
Atsuhiko Taniguchi, Hideyuki Okamoto, Shoya Usami, Akihiro Taguchi, Kentaro Takayama, Yoshio
Hayashi (Department of Medicinal Chemistry, School of Pharmacy, Tokyo University of Pharmacy andLife Sciences)

O-11

Development of a highly potent analogue and a long-acting analogue of oxytocin for the treatment ofsocial impairment-like behaviors
Stanislav Cherepanov1, Wataru Ichinose2, Shigeru Yokoyama1, Haruhiro Higashida1, Satoshi Shuto2(1Department of Basic Research on Social Recognition, Research Center for Child Mental Development,
Kanazawa University, 2Faculty of Pharmaceutical Sciences, Hokkaido University)

O-12

Synthesis of multiple functional peptides-conjugated dendrimers for cancer theranostics
Chie Kojima, Tatsumi Sato, Kento Nagai (Graduate School of Engineering, Osaka Prefecture University)

O-13

Light-controllable dithienylethene-modified peptides: towards drugs for photopharmacology
Sergii Afonin1, Oleg Babii1, Tim Schober2, Anne S. Ulrich1,2, Igor V. Komarov3 (1Institute of BiologicalInterfaces (IBG-2), Karlsruhe Institute of Technology (KIT), 2Institute of Organic Chemistry (IOC),
Karlsruhe Institute of Technology (KIT), 3Institute of High Technologies (IHT), Taras Shevchenko
National University of Kyiv)

10:20–10:35 Break
10:35–11:55 Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 4 (chairs: Yuji Hidaka, Takaki Koide)
O-14

Chemoenzymatic synthesis of biologics-fused hybrid molecules via NEXT-A reaction
Masumi Taki (The Graduate School of Informatics and Engineering, Dept. of Engineering Science, The
University of Electro-Communications (UEC))

O-15

Chemically modified phage-displayed helix-loop-helix peptide library for targeting protein kinase
Daisuke Fujiwara, Kousuke Mihara, Ryo Takayama, Yusuke Nakamura, Ikuo Fujii (Department ofBiological Science, Graduate School of Science, Osaka Prefecture University)

O-16

Magnetic alignment of microtubules by encapsulation of cobalt-platinum nanoparticles using a Tauderived peptide
Hiroshi Inaba1, Mayuki Yamada1, Arif Md. Rashedul Kabir2, Akira Kakugo2, Kazuki Sada2, Kazunori
Matsuura1 (1Graduate School of Engineering, Tottori University, 2Graduate School of Science, Hokkaido
University)

O-17

Identification of an antiviral component from the venom of the scorpion Liocheles australasiae
Masahiro Miyashita1, Naoya Mitani1, Atsushi Kitanaka1, Mao Yakio1, Ming Chen2, Sachiko Nishimoto3,Hak Hotta2,3, Yoshiaki Nakagawa1, Hisashi Miyagawa1 (1Graduate School of Agriculture, Kyoto
University, 2Graduate School of Health Sciences, Kobe University, 3Faculty of Clinical Nutrition andDietetics, Konan Women's University)(8)

11:55–12:00 Break
12:00–12:50 Luncheon Seminar
12:50–14:20 Poster Presentations ③ (P-201–P-253)

14:20–15:00 Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 5 (chairs: Yuji Ito, Hidehito Mukai)
O-18

Phase-separated co-assembly between peptide and lipid and shifted phase-transition temperature oflipid domain surrounded by peptides
Motoki Ueda1,2, Md. Mofizur Rahman2,3, Yoshihiro Ito1,2 (1Nano Medical Engineering Laboratory,
RIKEN Cluster for Pioneering Research, 2Emergent Bioengineering Materials Research Team, RIKEN
Center for Emergent Matter Science, 3Faculty of Allied Health Sciences, Daffodil InternationalUniversity)

O-19

Metal-peptide conjugates for photocatalytic CO2 reduction toward artificial photosynthesis
Hitoshi Ishida, Toshiya Motegi, Atsushi Ohtsuka, Chiaki Kojima, Jun Itabashi, Masaya Kamiya(Department of Chemistry, Graduate School of Science, Kitasato University)

15:00–15:10 Break
15:10–16:00 Lectures of the Young Investigator Award(chair: Yoshiaki Kiso)
Creation of peptide-tools using intramolecular reactions
Taku Yoshiya (Peptide Institute, Inc.)(chair: Akimitsu Okamoto)Novel strategies for peptide ligation toward epigenetic researchGosuke Hayashi (Department of Biomolecular Engineering, Graduate School of Engineering, NagoyaUniversity)
16:00–16:15 Break
16:15–16:55 Lectures of the Japanese Peptide Society Award(chair: Kenichi Akaji)
Cell adhesion research based on peptide science
Motoyoshi Nomizu (Department of Clinical Biochemistry, School of Pharmacy, Tokyo University ofPharmacy and Life Sciences)
16:55–17:05 Closing Remarks (Hirokazu Tamamura)(9)