INTERNATIONAL SYMPOSIUM ON
EPIGENOME 2019
Development of Fundamental Technologies forDiagnosis and Therapy Based upon Epigenome Analysis

Program & Abstracts BookFebruary 3 - 4, 2019
NATIONAL CANCER CENTER RESEARCH INSTITUTE

General Information
1. Dates
Sunday, February 3 - Monday, February 4, 2019

2. Venue
National Cancer Center Research Institute5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan

3. Chairs
Masayuki Yamamoto
Professor, Division of Medical Biochemistry, Tohoku University Graduate School of Medicine

Toshikazu Ushijima
Chief, Division of Epigenomics, National Cancer Center Research InstituteToshimasa Yamauchi
Professor, Department of Diabetes and Metabolic Diseases, Graduate School of Medicine,
The University of Tokyo

4. Registration
Date

Open - Close

Sunday, February 3

9:15 - 16:00

Monday, February 4

8:30 - 14:00

The registration desk is located on the 1st floor of the venue.
All participants are required to register at the registration desk.

5. Name badges
Name badges will be distributed at the registration desk. Please wear your name badge during
the sessions and the related events.

6. Social events (ISE 2019 Gathering)Time & Dates

Sunday, February 3 17:50 - 19:20

Venue

Seminar Room, 1F, National Cancer Center Research InstituteFees

JPY 6,000* Cash Only. Please kindly have the exact amount ready.

Advanced registrants are requested to pay the fees at the registration desk.

―4―General Information
7. Instructions for Speakers
Speakers need to bring their own PC for the presentation.
D-Sub 15 mini-pin and HDMI adapter will be available at the venue.
Please bring your own adapter if your PC does not have an output port for these types.

8. Instructions for Poster Presenters
Set UpViewing

Discussion

RemovalSunday, February 39:15 - 10:00

10:00 - 16:58

16:58 - 17:50―

Monday, February 4―

9:00 - 11:00―

11:00 - 12:00

Poster presenters are requested to set up their own poster(s) after the completion of theirregistration. Poster presentations will be conducted in free discussion style. Please remain near
the poster until the designated time is over. Any posters remaining after the removal time will bediscarded by the Secretariat.

9. Lunch
Lunch will NOT be provided.

10. Coffee break
Coffee will be served in the Seminar Room, 1F, National Cancer Center Research Institute.

11. Cloakroom
No cloakrooms will be available.

12. Meeting Policies
Photography and audio recording without permission is strictly prohibited.
Please set your cell phones into silent mode or turn it off during the sessions.

―5―

Map

―6―

Timetable―7―

Program
Sunday, February 3, 2019 [ Main Lecture Hall ]10:00-10:20

Opening Remarks
Masayuki Yamamoto
Eric Marcotte

10:20-12:36

Tohoku University
IHEC Executive Committee, Canada

Session 1: Epigenetics and development
Chair: Akiyoshi Fukamizu

University of Tsukuba

10:20-11:12 S1-01 Epigenetic Regulation in Development and DiseaceAlexander Meissner

Max-Planck Institute for Molecular Genetics

S1-02 Derivation and epigenome analysis of human trophoblast stem cells
Hiroaki Okae
Tohoku University*On behalf of Hiroyuki Sasaki
11:12-11:30 Break
11:30-12:36 S1-03 Direct reprogramming to hepatic and intestinal lineages

Atsushi Suzuki

Kyushu University

S1-04 Stress-dependent activation of p53 induces the transition to 2-cellembryo-like state of mouse ESC
Shinpei Yamaguchi
Osaka University*On behalf of Toru Nakano
S1-05 Epigenetic controls of germ cell development
Yasuhisa Matsui
Tohoku University
12:36-13:50Lunch Time

13:50-14:20

Rapid fire talk
Chair: Toshikazu Ushijima

National Cancer Center Research Institute

RFP-01 Difference in genetic and epigenetic regulations between young andold mice explored the mechanism of beta cell proliferation
Hisato Tatsuoka
Kyoto University
RFP-02 Mapping of histone-binding sites in histone replacement-completed
spermatozoa
Keisuke Yoshida
RIKEN
RFP-03 Active endogenous retroviruses drive species-specific changes in themammalian oocyte methylome and genomic imprinting
Hisato Kobayashi
Tokyo University of Agriculture―8―

Program
RFP-04 Genetic variation affects beige fat activity through genome-epigenome
interactions at the Ucp1 enhancer
Yuta Hiraike
The University of Tokyo
RFP-05 Interaction Analysis of Hi-C and Capture Hi-C data
Shuichi Tsutsumi
The University of Tokyo
RFP-06 Paternal aging affects to offspring’s behavior and gene expression
possibly through inheritance of hypomethylated DNA elicited inNRSF/REST binding site
Ryuichi Kimura
Tohoku University
RFP-07 Epigenomic landscape of human placental cytotrophoblasts andtrophoblast stem cells
Hidehiro Toh
Kyushu University
RFP-08 Transgenerational epigenetic inheritance caused by paternal restraint
stress in Drosophila
Ki-Hyeon Seong
Riken Tsukuba
RFP-09 Exacerbated methylation induction by NF-kB activation and nitricoxide
Hideyuki Takeshima National Cancer Center Research Institute14:20-16:58

Session 2: Transcription and epigentics
Chair: Hozumi Motohashi

Aging and Cancer (IDAC), Tohoku University

14:20-15:12 S2-01 Genome-wide co-localization of RNA-DNA interactions and fusion

RNA pairs
Sheng Zhong

Professor of Bioengineering, University of California,
San Diego

S2-02 Gene regulatory network for hematopoietic stem and progenitor
differentiation
Kazuhiko Igarashi
Tohoku University Graduate School of Medicine
15:12-15:30 Break
15:30-16:58 S2-03 The role of LSD1 family proteins in energy metabolism andpathophysiology

Mitsuyoshi Nakao

Kumamoto University

S2-04 Organization of 3D genome structure in Cornelia de Lange syndrome(CdLS)
Katsuhiko Shirahige The University of Tokyo
S2-05 Role of ATF2 family of transcription factors in epigenetic regulation byenvironmental factors
Shunsuke Ishii
RIKEN
S2-06 Epigenomic activation and inactivation induced by Epstein-Barr virus
infection in gastric epithelial cells
Atsushi Kaneda
Chiba University―9―Program
Sunday, February 3, 2019 [ Seminar Room ]16:58-17:50

Poster Session
RFP-01 Difference in genetic and epigenetic regulations between young andold mice explored the mechanism of beta cell proliferation
Hisato Tatsuoka
Kyoto University
RFP-02 Mapping of histone-binding sites in histone replacement-completed
spermatozoa
Keisuke Yoshida
RIKEN
RFP-03 Active endogenous retroviruses drive species-specific changes in themammalian oocyte methylome and genomic imprinting
Hisato Kobayashi
Tokyo University of Agriculture
RFP-04 Genetic variation affects beige fat activity through genome-epigenome
interactions at the Ucp1 enhancer
Yuta Hiraike
The University of Tokyo
RFP-05 Interaction Analysis of Hi-C and Capture Hi-C data
Shuichi Tsutsumi
The University of Tokyo
RFP-06 Paternal aging affects to offspring’s behavior and gene expression
possibly through inheritance of hypomethylated DNA elicited in
NRSF/REST binding site
Ryuichi Kimura
Tohoku University
RFP-07 Epigenomic landscape of human placental cytotrophoblasts andtrophoblast stem cells
Hidehiro Toh
Kyushu University
RFP-08 Transgenerational epigenetic inheritance caused by paternal restraint
stress in Drosophila
Ki-Hyeon SeongRiken Tsukuba
RFP-09 Exacerbated methylation induction by NF-kB activation and nitricoxide
Hideyuki Takeshima National Cancer Center Research InstituteP-01 Cluster analysis of chromatin state profiles in differentiating humantrophoblast cells
Daisuke Saito
Kyushu University
P-02 Reciprocal changes of H3K27ac and H3K27me3 at the promoter
regions of the critical genes for endometrial decidualization
Kazuhiko Nakabayashi National Research Institute for Child Health andDevelopment, Japan― 10 ―

Program
P-03 Exploring and characterizing the novel target genes of NFIA in brown
adipocytes
Misato OguchiThe University of Tokyo
P-04 A Role of NFIA in Beige Adipocytes Formation and Generation of Nfia
Transgenic Mice
Kaede Saito
The University of Tokyo
P-05 NFIA controls the early phase of adipogenesis through its C-terminal
proline-rich domain
Yuta Hiraike
The University of Tokyo
P-06 Cdyl2 is a chromodomain protein involved in pluripotency of stem
cells
Naoko Hattori
National Cancer Center Research InstituteP-07 Comprehensive epigenome characterization reveals the diverse
transcriptional regulation across human vascular endothelial cells
Ryuichiro Nakato
The University of Tokyo
17:50-19:20

ISE 2019 Gathering― 11 ―

Program
Monday, February 4, 2019 [ Main Lecture Hall ]9:00-10:36

Session 3: Epigenetic mechanism
Chair: Shoji Tajima

Osaka University

S3-01 Chromatin reprogramming in animal gametogenesis and early
development
Wei Xie
School of Life Sciences, Tsinghua University, Beijing,
China

S3-02 Structural views of recognition and demethylation of methy -CpGcontaining DNAs
Masahiro Shirakawa Kyoto University
S3-03 Epigenetic silencing mediated by a Setdb1-Atf7ip complex
Yoichi Shinkai
RIKEN
S3-04 Activation of Polycomb-repressed genes
Haruhiko Koseki
RIKEN
10:36-10:50

Break10:50-12:48

Session 4: Epigenetic disorder (1)Chair: Minoru Yoshida

RIKEN Center for Sustainable Resource Science

S4-01 Nutrient-dependent changes in the islet epigenome as a mechanism
for functional adaption of pancreatic beta cells
Maike Sander
Department of Pediatrics and Cellular & Molecular Medicine,
Pediatric Diabetes Research Center, University of California,
San Diego

S4-02 Integrative epigenomic and transcriptomic study of Williams syndrome
Masatoshi Hagiwara Kyoto University
S4-03 Aberrant DNA methylation of hypothalamic angiotensin receptor inprenatal programmed salt-sensitive hypertension
Toshiro FujitaThe University of Tokyo
S4-04 Epigenetic analysis of the mechanisms of metabolic control andtheir disruption in type 2 diabetes and obesity
Toshimasa Yamauchi The University of Tokyo
S4-05 Neuronal cell-type specific DNA methylation changes in prefrontal
cortex of patients with bipolar disorder
Kazuya Iwamoto
Kumamoto University*On behalf of Tadafumi Kato

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Program
12:48-14:00

Lunch Time

14:00-15:36

Session 5: Epigenetic disorder (2)Chair: Tsutomu Chiba

Kansai Electric Power Hospital

S5-01 Impact of ribosomal RNA chemical modifications on translational
control and tumorigenesis
Jean-Jacques Diaz
“Nuclear Domains and Pathologies”, Cancer ResearchCentre of Lyon (CRCL), France

S5-02 Genome-wide DNA methylation profiling in human cancers andits clinical application
Yae Kanai
Keio University
S5-03 Epigenetic Landscape in Multi-step Leukemogenesis in Down
Syndrome
Akira Watanabe
Kyoto University*On behalf of Tatsutoshi Nakahata
S5-04 Immune modulation by epigenetic modification of regulatory Tregs
Akihiko Yoshimura
Keio University
15:36-15:46

Closing Remarks
Toshikazu Ushijima
Toshimasa Yamauchi

National Cancer Center Research Institute
The University of Tokyo― 13 ―