Annual Meeting
The 23rd Annual Meeting of JSIT
Special Lecture
Inhaled Nanoparticles:
Consequences of Exposure andApproaches for Hazard
Identification

Victor J. Johnson

Burleson Research Technologies,Inc., Morrisville, North Carolina,
USA

Minoru Satoh

Department of Clinical Nursing,
School of Health Sciences,
University of Occupational andEnvironmental Health, Japan

Kazuyoshi Saito, Yoshiya
TanakaThe First Department of InternalMedicine, School of Medicine,
University of Occupational andEnvironmental Health, Japan

Master’s Lecture 1
Autoimmunity induced byadjuvants
Master’s Lecture 2
Toxicity and side effects ofimmunosuppressive drugs fortreatment in rheumatic diseases
Master’s Lecture 3(1)Department of Respiratory
Medicine, University ofClinical characteristics andmechanisms of drug-induced
pulmonary toxicity.

Occupational and Environmental
Kazuhiro Yatera(1), Takashi
Health, Japan, (2)SecondKido(1), Hiroshi Ishimoto(2), department of Internal Medicine,
Yasuo Morimoto(3), Hiroshi
Mukae(2)Nagasaki University School ofMedicine, (3)Department ofOccupational Pneumology,
University of Occupational andEnvironmental Health, Japan

Symposium「Estimation of pulmonary toxicity by fine and ultrafine particles and its socialpractice」
Organizers: Seishiro Hirano (National Institute for Environmental Studies), Hiroto Izumi (Universityof Occupational and Environmental Health, Japan)
Development of hazard
screening methods for industrial

Hiroto Izumi(1), Yukiko
Yoshiura(1), Takako(1)Department of Occupational
Pneumology, Institute of Industrial

nanomaterials: intratracheal
instillation study.

Oyabu(2), Toshihiko
Myojo(2), Yasuo
Morimoto(1)Ecological Sciences, University ofOccupational and Environmental
Health, Japan, (2)Department ofEnvironmental Health Engineering,
Institute of Industrial EcologicalSciences, University ofOccupational and Environmental
Health, Japan(1)Laboratory of Vaccine Science,
Immunology Frontier Research
Lung inflammation and allergy
induced by fine particles

Etsushi Kuroda(1),(2),(3),Ken J Ishii(1),(2),(3)Center, Osaka University,(2)Laboratory of Vaccine Design,
Center for Drug Design Research,(3)Laboratory of Adjuvant
Innovation, National Institute of
Biomedical Innovation, Health andNutrition

Development of devices toscreen asbestos exposure andYasumitsu Nishimura, Suni
Lee, Naoko Kumagai-Takei,

Department of Hygiene, Kawasaki

mesothelioma based on

Kei Yoshitome, Takemi

Medical School, Kurashiki, Japanimmunological analysis

Otsuki

From databases andbioinformatics to pulmonary

National Institutes of BiomedicalKenji Mizuguchi

diseases
Workshop:Innovation, Health and Nutrition,
Japan「Adverse outcome pathway (AOP) and immunotoxicity research」

Organizers: Shigeru Hisada (Innovative Drug Discovery Division, ASKA Pharmaceutical Co., Ltd.),
Tadashi Kosaka (Study Management Division, The Institute of Environmental Toxicology)
The Concept of development for
AOP in OECD

Hajime Kojima

National Institute of HealthSciences (NIHS)

The Adverse Outcome Pathway
on immunotoxicity of chemicals
that dysregulates the induction

Department of Dermatology,
Yutaka Kimura, Setsuya Aiba Tohoku University Graduate Schoolof Th subsets through affectingof Medicine, Japan

IL-2 transcriptional activity.
Shiho Ito, Kiyoshi Kushima,
The Adverse Outcome Pathway

Yasuharu Otubo, Takumi

AOP Working Group, Testingon immunosuppression causedby formation of FKBP12-FK506

Ohishi、Hiroyuki Komatsu,
Ken Goto、Junichiro

Methodology Committee, The
Japanese Society ofcomplex

Sugimoto, Yoshihiro

Immunotoxicology

Talahashi
Kiyoshi Kushima, Shiho Ito,
Yasuharu Otubo, Takumi

AOP Working Group, Testing

Point to note learned from theOhishi、Hiroyuki Komatsu,

Methodology Committee, Theexperience of AOP development

Ken Goto、JunichiroSugimoto, Yoshihiro

Japanese Society ofImmunotoxicology

Talahashi
The 6th JSIT Award Lecture (for Distinguished Contribution)

Immunotoxic effects of agrochemicals

Tadashi Kosaka

Study Management Division, The
Institute of EnvironmentalToxicology

The 6th JSIT Research Award Lecutre
Effects of environmental
chemicals on immune response

Department of Environmental andHiroyuki Kojima

via nuclear receptors.

Health Sciences, Hokkaido
Institute of Public Health, Sapporo

Students and Young Scientists Session (Oral and Poster)Construction of an in vivo Modelfor Evaluating the Immune-Takeshi Susukida, Shigeki

Laboratory of Biopharmaceutics,Mediated Idiosyncratic Drug
Toxicity Using Chimeric HLAAoki, Sota Fujimori, Kotaro
Kogo, Kousei Ito

Graduate School of Pharmaceutical
Sciences, Chiba University, Japan

Transgenic Mice
Analysis of Mechanism ofIdiosyncratic Drug toxicities

Sota Fujimori, Shigeki Aoki,

Using Keratinocyte Derived

Takeshi Susukida, Kousei Ito

From HLA Tg MiceLaboratory of Biopharmaceutics,
Graduate School of Pharmaceutical
Sciences, Chiba University, Japan

Oral Presentations
Detection of autoantibodies to(1)University of Occupational androds and rings structure (RR) inJapanese patients with chronic

Shin Tanaka(1), Tamiji
Nakashima(1), Takashi

Environmental Health, Japan.,(2)Clinical Examination

hepatitis C virus (HCV) infection

Himoto(2), Minoru Satoh(1)Department, Kagawa Prefecturalusing commercial HEp-2 slides

University of Health Sciences

The responsible for the decrease Kido Takamasa, Yogosawa
in anti-inflammatory M2

Shingo, Yoshioka Wataru,

macrophages in the spleen androle of IL-4 in Zn-deficient rats

Suga Machi, Yanagisawa
Hiroyuki

LPS-rich urban particulatematter 10 suppresses immune
responses in splenocytes

Department of Public Health andEnvironmental Medicine, Jikei
University School of Medicine

Yasuhiro Yoshida(1), Yuan
Song(1), Cuiying He(1),(1)Department of Immunology
and Parasitology, University ofOccupational and Environmental

Kentaro Morita(1), Takamiti
Ichinose(2), Tamotsu
Kanazawa(1)Health, Japan, (2)Department ofClinical Laboratory, the Fourth
Hospital of Hebei MedicalUniversity

Perturbation of lysosomal pH insilver nanoparticle-induced
cellular damage in A549 cells
The effects of cleaning solvent
or tetrachloroethylene on themRNA expressions of humanimmortal keratinocyte cell line
HaCaT

Takamitsu Miyayama,
Masato Matsuoka

Department of Hygiene and Public
Health I, School of Medicine,Tokyo Women’s Medical University

Masashi Tsunoda(1), Chiemi(1)Department of Hygiene,

Sugaya(1), YumikoSugiura(1)Kitasato University School ofMedicine, Japan

Production of IL-1β and changes
in p62/SQSTM1 and LC3 inmacrophages following
simultaneous exposure toSeishiro Hirano(1) andSanae Kanno(2)Marianna Univ. School of Medicine

particles and LPS.
The comparison of expression
levels of oxidative(1)Center for Health andEnvironmental Risk Research,
Natl. Inst. Environ. Studies, (2)St.

Takemi Otsuki,ShokoYamamoto, Suni Lee,phosphorylation-related
Tamayo Hatayama, Hidenori
complexes in human T cell lines,
Matsuzaki, Naoko KumagaiMT-2 and its sublines
Takei, Kei Yoshitome,
continuously exposed toYasumitsu Nishimuraasbestos fibers

Department of Hygiene, Kawasaki
Medical School

Tomonori Hayashi(1),Impact of aging and radiation
on influenza vaccine response
among Atomic-bomb Survivors

Heather E. Lynch(2), SusanGeyer(3), Kengo Yoshida(1),(1)Radiation Effects Research

Ikue Hayashi(4), JunkoKajimura(1), Seishi
Kyoizumi(1), Yoichiro

Foundation, (2)Duke University
Medical Center, (3)University ofSouth Florida, (4)Hiroshima

Kusunoki(1), WakaOhishi(1), Saeko
Fujiwara(5), Ivo Shterev(2),University Faculty of Dentistry,(5)Hiroshima Atomic Bomb
Casualty Council, (6)University ofJanko Nikolich-Zugich(6)Donna Murasko(7), Gregory
D. Sempowski(2), Kei

Arizona College of Medicine,(7)Drexel University

Nakachi(1)Evaluation of immunological test
in a four-week repeated dose
toxicity study ofcyclophosphamide in
Microminipig

Hiroyuki Komatsu, Masaki
Kunieda, Hiroyuki Saito,Takayuki Kubota, Miyuki
Takao, Kumiko Kitta,
Yoshiyuki Suzuki, Hiro Eda

Bioresearch Center, CMIC Pharma
Science Co., Ltd.

and Yasuki Akie

Identification of MHC-associatedShunsuke Ito, Nobuo
Sekiguchi, Tatsuya Ikuno,

peptides presented by human
iPS cell-derived dendritic cells(hiPS-DCs)

Toshiko Hara, Ayako
Takahashi, Mitsuyasu Tabo,
Shuichi Chiba, Tomoaki

Research Division, Chugai
Pharmaceutical Co., Ltd.,
Gotemba, JapanInoue
Poster Presentations
Toll-like receptor 4 plays a rolein diesel exhaust origin
secondary organic aerosolinduced impaired spatial

Tin Tin Win Shwe, EikoKoike, Rie Yanagisawa, YujiFujitani, Seishiro Hirano

learning ability in neonatal mice
Effects ofhexabromocyclododecane on

Eiko Koike, Rie Yanagisawa,Tin Tin Win ShweCenter for Health andEnvironmental Risk Research,
National Institute forEnvironmental Studies
Center for Health andEnvironmental Risk Research,inflammatory response inadipocytes and macrophages

National Institute forEnvironmental Studies
Reiko Teshima(1), Shinobu

Analysis of the appearance of
deamidated epitope after acidhydrolyzation of wheat gluten

Sakai(1), Masashi
Nakamura(2), Yoshiaki
Ikarashi(1), Olivier

using epitope-specificmonoclonal antibody

Tranquet(3), Sandra Denery- School of Med, (3)French Natl.
Papini(3), Kayoko
Inst. Agricul. Res.
Matsunaga(2)Effects of maternal exposure tobenzo[a]pyrene during neonatal
periods on airway allergic
inflammation in offspring.

Rie Yanagisawa(1), Eiko

(1)Natl. Inst. Health Sci.,(2)Dep.Integrative Med. Sci.for
Allerg.Dis., Fujita Health Univ.

(1)Molecular Pathology Section,
Center for Health andEnvironmental Risk Research,

National Institute forKoike(1), Tin-Tin WinEnvironmental Studies,Shwe(1), Hirohisa Takano(2)(2)Graduate School ofEngineering, Kyoto University,Kyoto, Japan.

In vitro solid phase cytokine

Shiho Ito(1), Kyoko Miwa(1),release assay with preincubation of human peripheral
blood mononuclear cells

Chiharu Hattori(2), Hitomi
Terada(1), Tetsuo Aida(1),Yoshimi Tsuchiya(1)(1) Medicinal Safety ResearchLaboratories, DAIICHI SANKYO
CO., LTD., (2) Biologics &Immuno-Oncology Laboratories,
DAIICHI SANKYO CO., LTD(1)Division of Medicinal Safety
Science, National Institute ofEffects of Infectious Diseases inthe Pathogenesis of StevensJohnson Syndrome/Toxic
Epidermal Necrolysis.

Health Sciences, Tokyo, Japan,
Yoshimi Okamoto-Uchida(1),(2)Department of Integrative
Ryosuke Nakamura(1),Medical Science for Allergic
Kimie Sai(1), Takuya
Disease, School of Medicine, FujitaImatoh(1), Kayoko
Health University, Aichi, Japan,Matsunaga(2), Michiko(3)Department of Environmental
Aihara(3), Yoshiro Saito(1)Immuno-Dermatology, Graduate
School of Medicine, Yokohama City
University, Kanagawa, Japan

Analysis on immunogenicity oftherapeutic proteins using risk
management plans.

Yoshiro Saito(1), Yoshimi(1)Division of Medicinal Safety
Science, National Institute ofOkamoto-Uchida(1),Health Sciences, Japan,
Ryosuke Nakamura(1), Akiko (2)Division of Biological Chemistry
Ishii-Watabe(2)and Biologicals, National Instituteof Health Sciences

Impact of combined exposure toRisako Tajiki, Tomoki
immunosuppressive chemicals
Fukuyama, Yuko Watanabe, The Institute of Environmental
on the respiratory allergic
Hideo Ueda, Tadashi Kosaka, Toxicology
inflammation in the next
Takanori Haradageneration

Naoko Kunagai-Takei,
Effect of IL-15 addition on thesuppressed induction of human
CTL upon exposure to asbestos

Yasumitsu Nishimura,
Hidenori Matsuzaki, Suni
Lee, Kei Yoshitome, TakemiDepartment of Hygiene, Kawasaki
Medical SchoolOtsuki
Comparison of detectability ofthe anti-drug antibody between

Kazuko Nishimura(1),Chizuru Miyama(1), Minoru

SPR and ECL bridging assay
using WHO anti-EPO antibody
reference panel.

Tada(1), Takuo Suzuki(1),Yoshiro Saito(2), Akiko IshiiWatabe(1)Statistical analysis between

Suni Lee(1), Yasumitsu
Nishimura(1), Hidenori
Matsuzaki(1), Naoko
Kumagai-Takei(1), Kei

plasma DcR3 and clinicalparameters in silicosis patients.

Yoshitome(1), HiroakiHayashi(2), Masayasu
Kusaka(3), Wataru
Fujimoto(2), Takemi
Otsuki(1)Division of Biological Chemistry
and Biologicals, (2)Division ofMedicinal safety Science, National
Institute of Health Sciences, Japan(1)Kawasaki Medical School, Dept.
Hygiene, (2)Kawasaki Medical
School, Dept. Dermatology,(3)Kusaka Hospital(1)Department of Hygiene,

Effect of short-term and longterm exposure of asbestos on
MT-2 cells.

Hidenori Mastuzaki(1), Suni
Lee(1), Megumi Maeda(2),Naoko Kumagai-Takei(1),Yasumitsu Nishimura(1),Takemi Otsuki(1)Kawasaki Medical School,(2)Laboratory of Functional
Glycobiochemistry, Department of
Biofunctional Chemistry, Divisionof Agricultural and Life Science,Graduate School of Environmental
and Life Science, Okayama
University

Effects of vehicle-exhaust
particle uptake by human nasal
epithelial cells on
cytokine/chemokine production
In immunosuppressive agent,integrated assessment of thehuman and of toxicity test PK /PD measurement

Akira Onodera(1), Arisa
Morikawa(1), Masashi
Kawasaki(1), Kosuke(1)Division of BiopharmaceuticalSciences, Faculty of Pharmacy

Taniguchi(1), Katsutoshi
Yayama(1), Yuichi Kawai(1)Science, Kobegakuin University

Hiroyoshi Saito(1)、MichikoSakamoto(2)、AkihikoMorishita(2)、Yasuyuki
Ito(3)、Shinko Hata(2)(1)Hyogo Pet Medical Center
Higashinada, (2)Ig-M., Ltd..
(3)National Center of Neurology
and Psychiatry

Luncheon Seminar 1 (Envigo Co., Ltd.)Key considerations in the safety
evaluation of drugs targeting
immune checkpoints

Lee Coney

LS-01
uncheon Seminar 2 (Charles River Laboratories Japan, Inc.)

Envigo CRS Limited

Examples of novel approaches
of assessing preclinicalimmunotoxicity including
antibody-drug conjugates using
flow cytometry

Director, Immunotoxicology,
Vanessa L. Peachee

Charles River Laboratories
Ashland, LLC

The Japanese Society of Immunotoxicology