The 17th Annual Meeting of JSIT
Invited Plenary Lecture
A. Dean Befus, Tae
Chul Moon, Yokananth
Mast cells and theirSekar, Chris St.
Pulmonary Research Group,
regulation: Allergy, but so
Laurent, Tsuyoshi
School of Internal Medicine,much more – Innate toYoshimura, Candy
University of Alberta, Canada
adaptive immunity”
Marcet, Shinji Takeuchi,
Katherine Morris.
Special Lecture
Molecular mechanisms
underlying pathogen
sensing in the innate
immune system

Kensuke Miyake

The Institute of Medical Science,
The University of Tokyo

Jun-ichi Sawada

Pharmaceuticals and Medical
Devices Agency, Tokyo, JapanMaster’s Lecture
Allergenicity testing:current and future issues

Symposium "Immunotoxicity and chemical susceptibility"
Influenza viral disease:
Dexamethasone and therole of age and genetics
on viral disease

Gary R. Burleson

Responses ofmacrophages against
oxidative stress- roles oftranscription factor Nrf2
and the induced proteins

Effects of volatile organic
compounds (VOCs)
exposure on
immunotoxicity in mice

Yellow sand and allergy

Tetsuro Ishii, Toru
Yanagawa, Eiji Warabi

Naoki Kunugita (1),Yasuhiro Yoshida (2),Win Shwe Tin Tin (3),Keiichi Arashidani (2),Hidekazu Fujimaki (3)BRT-Burleson ResearchTechnologies, Inc, USA

Majors of Medical Sciences,
Graduate School ofComprehensive HumanSciences, University of Tsukuba(1) Department ofEnvironmental Health, National
Institute of Public Health, Wako,Japan, (2) University ofOccupational and Environmental
Health, Kitakyushu, Japan, (3)Research Center for
Environmental Risk, National
Institute for Environmental
Studies, Tsukuba, Japan

Takamichi Ichinose (1), (1) Department of Health
Masataka Nishikawa
Sciences, Oita University of(2), Hirohisa Takano (3) Nursing and Health Sciences,Oita, Japan, (2) Laboratory ofIntellectual Fundamentals forEnvironmental Studies, National
Institute for EnvironmentalStudies, Tsukuba, Japan, (3)Environmental Health Sciences
Division, National Institute forEnvironmental Studies, Tsukuba,Japan
Effect of chemicals likebrominated flame
retardants (BFRs) on the

Reiko Teshima, Ryosuke

development of theimmune system inNakamura

The Division of Novel Foods andImmunochemistry, National
Institute of Health Sciences

rodents
Workshop “The latest move in the immunotoxicity studies: in silico, in vitro and invivo”
In silico prediction ofimmunogenicity: sense

Philippe Stasand non-sense

Biologics.
Japanese Center for theCurrent situation of invitro testings on skinsensitisation assay

Applied Protein Services, LonzaHajime Kojima

Validation of AlternativeMethods, National Institut e of
Health Sciences

Kanako Mori (1),Yasuhide Kouchi (2), Ai
Hashimoto (3), Hideki
Harada (4), Ryota
Kawai (5)(1) Development ResearchCenter, Takeda Pharmaceutical
Company Limited, (2) Toxicology
Lab., Tokushima ResearchCenter, Taiho PharmaceuticalCo., Ltd., (3) Discovery
Technology Laboratories, Minase
Research Institute, Ono
Pharmaceutical Co. Ltd., (4)Safety Assessment Department,
Non-clinical Research Center,
Drug Development ServiceSegment, Mitsubishi Chemical
Medience Corporation, (5)Medicinal Safety ResearchLaboratories, Daiichi Sankyo Co.,Ltd.

yota Kawai (1), Yuko
Nagayama (2), Kanako
Mori (3), Yasuhide
Kouchi (4)(1) Medicinal Safety ResearchLaboratories, Daiichi Sankyo Co.,
Ltd., (2) Tsukuba, Drug Safety
Japan, Eisai Co., Ltd., (3)Development Research Center,
Takeda Pharmaceutical Company
Limited, (4) Toxicology Lab.,
Tokushima Research Center,
Taiho Pharmaceutical Co., Ltd.

Particulates activate
innate immune systems
and regulate type 2
immunity

Etsushi Kuroda (1),Yasuo Morimoto (2)(1) Department of Immunology
and Parasitology, University ofOccupational and EnvironmentalHealth, (2) Department ofOccupational Pneumology,
University of Occupational andEnvironmental Health

Safety assessment ofnanomaterials:
inflammatory responses

Yasuo Yoshioka (1,2,3), (1) The Center for Advanced
Tomohiro Morishige (3), Medical Engineering andHiroshi Inakura (3),Informatics, Osaka University,

The inter-laboratory KLHTDAR assay validation
study (Study I ) –investigation for theexperimental conditions –The inter-laboratory KLHTDAR assay validation
study II– investigation
using animmunosuppressiveagent –Oral Presentations

of nanosilica withdifferent sizes andTomoaki Yoshikawa
Osaka, Japan, (2) Laboratory of(2,4), Shin-ichi Tsunoda Biopharmaceutical Research,surface properties(1,2,5), Yohei Mukai

National Institute of Biomedical(3), Naoki Okada (3),Innovation, Osaka, Japan, (3)Shinsaku Nakagawa

Department of Biotechnology(1,3), Yasuo Tsutsumi

and Therapeutics, Graduate(1,2,4)

School of PharmaceuticalSciences, Osaka University,Osaka, Japan, (4) Department of
Toxicology and Safety Science,Graduate School of
Pharmaceutical Sciences, Osaka
University, Osaka, Japan, (5)Department of Biomedical
Innovation, Graduate school ofPharmaceutical Sciences, Osaka
University, Osaka, JapanFunctional analysis ofperipheral blood CD8+
cells from people positivefor pleural plaqueNaoko Kumagai,
Department of Hygiene,
Yasumitsu Nishimura,
Kawasaki Medical School,
Megumi Maeda, Hiroaki
Kurashiki, Japan
Hayashi, Takemi Otsuki

Analysis of Foxp3
expression and DNA
methylation in MT-2 cells
exposed to asbestos

Megumi Maeda (1),Hiroaki Hayashi (1),Yasumitsu Nishimura(1), Naoko Kumagai(1), Yoshie Miura (2),Takemi Otsuki (1)Yasuo Morimoto (1),Masami Hirohashi (1),
Akira Ogami (1),
Takako Oyabu (1),Toshihiko Myojo (1),Motoi Todoroki (1),(1) Department of Hygiene,
Kawasaki Medical School,
Okayama, Japan, (2)Department of MolecularGenetics, Medical Institute ofBioregulation, Kyushu University,
Fukuoka, Japan(1) IIES, University ofOccupational and Environmental

Pulmonary toxicity

Makoto Yamamoto (1), Health Japan, Kitakyushu,
Masayoshi Hashiba (1), Japan, (2) Dept of Immunology,
Yohei Mizuguchi (1),
School of Medicine, University of

induced by dispersed
MWCNT using animal

Byeong Woo Lee (1),
Etsushi Kuroda (2),Occupational and Environmental
Health Japan. Kitakyushu,studiesManabu Shimada (3),Wang Wei-Ning (3),Japan, (3) Hiroshima University,Hiroshima, Japan, (4) National

Kazuhiro Yamamoto(4), Katsuhide Fujita(4), Shigehisa Endoh

Institute of Advanced Industrial
Science and Technology,Tsukuba, Japan(4), Kunio Uchida (4),Norihiro Kobayashi (4),Junko Nakanishi (4),Isamu Tanaka (1)Altered production ofcytokines and decreased
Yasumitsu Nishimura,monocyte-lineage cells in
Department of Hygiene,
Naoko Kumagai,
the relation with
Kawasaki Medical School,
Megumi Maeda, Hiroaki
decreased NKp46 on NK
Kurashiki, Japan
Hayashi, Takemi Otsuki
cells upon exposure toasbestos

Environmental Health Sciences

Effects of brominatedflame retardants on

Eiko Koike, Rie
Yanagisawa, Hirohisa

mouse immune cells

TakanoZiram induces apoptosis

Qing Li, Maiko

Department of Hygiene andand necrosis in humanimmune cells

Kobayashi, Tomoyuki
KawadaPublic Health, Nippon Medical
School, Tokyo, Japan

Inhibitory effects ofpesticides on IL-17
production via retinoid-Hiroyuki Kojima (1),Shinji Takeuchi (1),
Miki Takahashi (2),Health, Sapporo, Japan , (2)Graduate School of
Pharmaceutical Sciences,

related orphan receptor

Ryuta Muromoto (2)Hokkaido University, Sapporo,
JapanDivision, National Institute forEnvironmental Studies, Tsukuba,Japan(1) Hokkaido Institute of Public

In vitro T cell-dependent
antibody response assay
using mouse splenocytes
Analysis of human
lymphocyte chemotaxis
by TAXIScan method
Developement of themethod for chemical risk
assessment based onhuman leukocytes
chemotaxis
Contamination by
endotoxin masks thepositive immunogenic
reaction in helper T-cellproliferation assay

Kiyoshi Kushima, Shogo
Matsumura, Akihiko
Hisatomi, Michio
Fujiwara, Jiro SekiAkira Yamauchi (1),Drug Safety Research Labs.,
Astellas Pharma Inc., Osaka,Japan(1) The Department ofBiochemistry, Kawasaki Medical
Futoshi Kuribayashi (1),
School, Kurashiki, Japan , (2)Shiro Kanegasaki (2)The Central Laboratory, ECI, Inc.
Tomoko Tsuchiya,
Minoru Ono, Shiro
Kanegasaki

Department of Research, ECI,
Inc., Tokyo, Japan

Marie Hayakawa,
Chiyomi Kubo, Yoshika
Iwata, Shunsuke Itou,
Toshiko Hara, Akihumi
Shioda, Masayuki
MishimaFuji Gotemba Res. Labs., Chugai
Pharmaceutical Co., Ltd.,
Gotemba, Japan

Chiyomi Kubo, Marie
Helper T-cell proliferation
assay to measure T-cell
response to various
antibody pharmaceuticals

Hayakawa, Shunsuke
Ito, Taichi Kuramochi,
Yoshika Iwata, Akifumi
Shioda, Toshiko Hara,

Chugai Pharmaceutical CO., LTD.
Fuji Gotemba Research Labs.

Tomoaki Inoue,
Masayuki Mishima
Yoshika Iwata (1),Chiyomi Kubo (1),

Risk assessment ofMarie Hayakawa (1),
Shunsuke Ito (1),(1) Safety Assessment Dept.,
Fuji Gotemba Res. Labs., Chugai

cytokine release
syndrome using humanToshiko Hara (1),Akifumi Shioda (1),Pharmaceutical Co., Ltd.,
Gotemba, Japan, (2)peripheral blood cells invitro

Tomoaki Inoue (1),Masayuki Mishima (1),
Manigold Tobias (2),Immunosafety, Non-clinical
Safety, F Hofmann La-Roche Ltd,Basel, Switzerland

Hinton Heather (2),Kropshofer Harald (2)Sensitization study byquantitative structureactivity relationships(QSAR)

Kazuhiro Sato, Yukinori
KusakaDepartment of Environmental
Health, School of Medicine,
University of Fukui, Fukui, JapanDepartment of GeriatricKatsunori Yamaura, Seri
Pharmacology and Therapeutics,
Akiyama, Manabu Oda,
Graduate School ofexacerbation of childhood Eriko Suwa, Koichi
Pharmaceutical Sciences, Chiba
allergic dermatitis byUeno
University
Development of animalmodel represent

STAT5 is activated byformaldehyde inhalation
during pregnancy andinfancy.

(1) Department of Immunology
and Parasitology, School ofYasuhiro Yoshida (1),Ning Ding (1), Naoki

Medicine, University ofOccupational and Environmental

Kunugita (2)Health, Kitakyushu, Japan, (2)National Institute of Public
Health, Wako, Japan

Effects of oral exposureto γ-benzene
hexachloride duringchildhood in allergic
airway inflammation

Rie Yanagisawa, EikoKoike, Hirohisa Takano

Hiroshi Akiyama (1),
Hideki Matsuoka (1),β-carotene intake inhibits Kozue Sakata (1), Rika
oral sensitization andNakamura (1), Shingo

National Institute forEnvironmental Studies,
Environmental Health Sciences
Division, Tsukuba, Japan(1) National Institute of Health
Sciences, Tokyo, Japan, (2)Research Institute, KAGOME

affects intestinal mucosal Takahashi (2), Takahiro CO., LTD., Nasushiobara-chi,immunity
Inakuma (2), Mamoru
Japan, (3) The University ofTotsuka (3), Reiko
Teshima (3)Histological Features andAirway
Hyperresponsiveness in
Polycyclic Aromatic
Hydrocarbons
Exacerbated Allergic
Reaction in BALB/c mice

Tokyo, Tokyo, Japan

Ryoji Hirota (1), Yumei(1) Department ofEnvironmental Medicine, Kochi

Kang (2), Hiroyuki
Nakamura (3),Medical School, Nankoku, Japan,(2) Laboratory of Soil

Narufumi Suganuma(1), Katsutoshi Sakurai

Environmental Science, Kochi
University, (3) Kanazawa(2)

University Graduate School of
Medical Science

Aye Mu Myint (1),
Cytokines and tryptophan
Matthias Rothermundt
metabolites changes in(2), Michael Riedel (1),mood disorders: Genetic
Markus Schwarz (1),and biochemical aspects
Stephan Claes (3)(1) PNI Laboratory, Psychiatric
Hospital, Ludwig-Maximilians
University, Munich, Germany, (2)Psychiatric Hospital, Universityof Muenster, Muenster, Germany,(3( Psychiatric Hospital, Katholic
University of Leuven, Leuven,
Belgium

Poster Presentations
Prior exposure toorganophosphorus andTomoki Fukuyama,
Yukari Tajima, Hideo

organochlorine
Ueda, Koichi Hayashi,
compounds increases the Yasufumi Shutoh,
allergic potential ofchemical allergens

Tadashi Kosaka,
Takanori Harada

The comparison ofTakemi Otsuki, Megumi
Maeda, Shoko

immunological effects of Yamamoto, Hiroaki
Chrysotile and Crocidolite Hayashi, Naoko
asbestos fibers

Kumagai, Yasumitsu
NishimuraThe Institute of Environmental
Toxicology, Toxicology Division,Ibaraki, Japan

Department of Hygiene,
Kawasaki Medical School,Kurashiki, Japan

(1) Department of Hygienic
Masakazu Umezawa(1,2,3), Chika Sakata
Effect of diesel exhaust
exposure on allergic
reactions in the rat
endometriosis model

Chemistry, Faculty of
Pharmaceutical Sciences, Tokyo
University of Science, Noda-city,

Chiba, Japan, (2) Department of(1), Masako Tabata (1),Pathology, Tochigi Institute ofNaomi Tanaka (1),Clinical Pathology, Nogi-town,
Sayaka Kudo (1), Yumi
Chiba, Japan , (3) Research
Saito (1), Tomomi Ihara
Center for Health Sciences of(2), Masao Sugamata
Nanoparticles, Research(2), Ken Takeda (1,3)
Institute for Science andTechnology, Tokyo University ofScience, Noda-city, Chiba, Japan

Effect of postnatal
exposure to low-level

Shoji Yamamoto, Tin-Research Center for

toluene withpeptidoglycan on theTin Win-Shwe, Daisuke
Nakajima, Hidekazu

Environmental Risk, NationalInstitute for Environmental

development of Th1/Th2

FujimakiStudies, Tsukuba, Japanbalance in mice

Murine oral food allergy

Tomoko Shindo (1),Terumi Katori (1),model: Analysis of T cell

Yukiko Kanazawa (2),subpopulations inMotoyasu Ohsawa (1),mucosal lymphoid tissues Kohichi Kojima (1),Reiko Teshima (3)(1) Hatano Research Institute,
Food and Drug Safety Center,Hadano, Japan, (2)Pharmaceuticals and Medical
Devices Agency, Tokyo, Japan,(3) National Institute of Health
Sciences, Tokyo, Japan

Shinji Takeuchi (1,2)，
Mast cells express
hormone receptors, but

Morris Katherine (2)，
St. Laurent Chris (2)，(1) Hokkaido Institute of Public

treatment with estrogen

Moon Tae Chul (2)，吉Health, Sapporo, Japan, (2)exerts no detectable

村剛(2)，Sekar

University of Alberta, Edmonton,

influence on mast cellsecretions

Yokananth (2)，Hiroyuki Kojima (1)，CanadaBefus Dean (2)The effect of thematernal consumption oflactic acid bacteria during
pregnant and lactating
periods on theirpregnancy and offspring

Gaku Wagai, Kazuhiko
Yoshizawa, Toshihide

Yakult Central Institute for

Kobayashi, Ikuo Kato,

Microbiological Research

Kazumi Uchidain mice
A comparative study ofSlc: WistarHannover/Rcc
rats and Slc: SD rats
onimmunotoxicological

Yoshito Ohnuma,

Department of Life & HealthYasuyuki Maeda

Sciences, Teikyo University ofScience, Yomanashi, JapanThe alterations in thesubsets of splenic

Masashi Tsunoda (1),Takamasa Kido (1),(1) Department of Preventive
Medicine and Public Health,lymphocytes among theRyutaro Ikeuchi (1),Kitasato University School of

F1 rats exposed totributyltin via theTakaya Kaido (1),Mayuko Hosokawa

Medicine, Sagamihara, Japan ,(2) Department of Epidemiology

placenta and their dams’(1,2), Chiemi Sugayaand Environmetal Health,milk(1), Yuichiro Kudo (1),Juntendo University School ofKoichi Hayashi (3),Tadashi Kosaka (3),Medicine , (3) The Institute ofEnvironmental Toxicology , (4)characteristics

The detection of immunosuppressive effects ofDPH or MXC in female
mice using Plaqueforming cell (PFC) assay

Yuki Takeuchi (4),Tomoko Tashiro (4),

Aoyama Gakuin University
School of Science andYoshiharu Aizawa (1)Engineering

Koichi Hayashi, Tomoki
Fukuyama, YukariTajima, Yukiko

The Institute of Environmental

Kashimoto, Yasufumi
Shutoh, Hideo Ueda,

Toxicology

Tadashi Kosaka(1) Div. Novel Foods
Ryosuke Nakamura (1), Immunochem., Natl. Inst.

Cross-reactivity analysisof allergens revealed byEXiLE test

Masakazu Higuchi (1),Health Sci., Tokyo, Japan, (2)Rika Nakamura (1),Yasuto Kondo (2),Dept. Pediatrics, Fujita Health
Univ. Sch. Med., Toyoake, Aichi,Atsuo Urisu (3), Reiko

Japan, (3) Dept. Pediatrics, TheTeshima (1)Second Teaching Hospital of
Fujita Health Univ., Aichi, Japan

Emiko Sugiyama (1,2),
Nahoko Kaniwa (1,2),
Masahiro Tohkin (1,2),
Kouichi Kurose (1,2),
Associations between

Ryuichi Hasegawa (2),(1) Division of Medicinal of
Kayoko Matsunaga (2),Safety Science, National
Yukitoshi Takahashi (2),Institute of Health Sciences,
toxic epidermal necrolysis Hirokazu Furuya (2),Tokyo, Japan, (2) JSCAR
in Japanese patients
Masaaki Muramatsu
Research Group(Third report)(2), Chie Sotozono (2),Shigeru Kinoshita (2),
HLA alleles and StevensJohnson syndrome andMichiko Aihara (2),Zenro Ikezawa (2),
Yoshiro Saito (1,2)
Shiho Ito, Hiroyuki
Immunotoxicity

Hattori, Ryota Kawai,
Satomi Komatsu, Keikoevaluation in rats using T- Muramatsu, Masae
cell independent antibody Yagi, Takuya
responseMatsuyama, Tadashi

Medicinal Safety ResearchLaboratories, Daiichi Sankyo Co.,
LTD., Shizuoka, JapanFurukawa, Atsushi
Sanbuissho
Masafumi Horiuchi (1),
Hideki Miyaura (1),
Accuracy of LLNA: BrdUELISA to detect skinsensitization potential ofchemicals

The Comparison of(1) Chemicals Assessment andResearch Center, Chemicals

Naoaki Yakata (1),Evaluation and Research
Masahiro Takeyoshi (1),Institute, Japan, (2) Hita
Naomi Kawazu (2),Laboratory, Chemicals
Masanori Taruki (2),Evaluation and Research
Nobuhiko Higashibara
Institute, Japan(2)Hiroaki Oka, Mitsuhiro

Reaction in Rats

Tokushima Research Center,Fujieda, Hiroko
Taiho pharmaceutical Co., Ltd.,
Hitotsumachi, YasuhideJapanKouchi

Four Week RepeatedMakoto Tsunemi, Hideki Safety Assessment Department,

testing Conditions for T
cell Dependent Antibody

Dose Oral Immunotoxicity Tokudome, Takayuki

Mitsubishi Chemical Medience

Study ofCorporation, Kashima, Japan

Okamura, Hideki
Harada, Yasuyuki

Cyclophosphamide andCyclosporin A in Rats

Ohnishi, Hideaki
Hiratsuka

A New In Vitro Assay

Terumi Katori (1),(1) Hatano Research Institute,

System for Assessment of Tomoko Shindo (1),Food Allergenicity (2)Motoyasu Ohsawa (1),Food and Drug Safety Center,Hadano, Japan, (2) National

Evaluation of Proteins

Kohichi Kojima (1),Institute of Health Sciences,

Digested In Vitro

Reiko Teshima (2)Tokyo, Japan

Oral Presentations (Students' Session)(1) Department of Oral andMaxillofacial Reconstructive
Change in expression

Seiko Takeda (1),pattern of human β

Tomoichirou Yamaai

defensins in mouse(2), Nobuyoshi

tracheal epithelium
induced by toluene
exposure

Surgery, Okayama University
Graduate School of Medicine,
Dentistry and PharmaceuticalSciences, Okayama, Japan., (2)Mizukawa (1), Yoshihiro
Department of Oral Function andKaneda (1), Seiji Iida
Anatomy, Okayama University(1)
Graduate School of Medicine,
Dentistry and PharmaceuticalSciences, Okayama, Japan

Enhancement ofproliferation ofsplenocytes induced byfullerene nanoparticles
instillation

Ning Ding (1), Naoki(1) Department of Immunology

Kunugita (2), Takamichi and Parasitology, UOEH, (2)Ichinose (3), Yuan Song National Institute of Public(1), Keiichi Arashidani
Health, (3) Oita University of(4), Yasuhiro YoshidaNursing and Health Sciences, (4)(1)

School of Health Sciences, UOEH
(1) Environmental Health

Mechanism of the
suppression oflymphocyte proliferation
through an increase inp130 by inorganic arsenic

Sciences Division, National
Kazuyuki Okamura(1,2), Daisuke Miki

Institute for Environmental
Studies, Tsukuba, Japan, (29(1,2), Keiko Nohara

Graduate School of Life and(1,2)

Environmental Sciences,Tsukuba University, Tsukuba,JapanThe mechanism forregulating the interleukin- Masashi Asao, Daigo
6 in exposure toSumi, Seiichiro Himeno

manganese

Faculty of PharmaceuticalSciences, Tokushima Bunri
University, Tokushima, Japan

Luncheon Seminar
Impact of the addendum
to ICH S6 on the usage oftissue cross-reactivity
studies in the pre-clinical

Special Pathology Services,Curtis Chandevelopment of antibodybased biopharmaceuticals

Charles River Laboratories,
Preclinical Services, USA

Therapeutic monoclonal
antibodies - Predicting
antibody-mediatedcytokine release

Christopher Kirton

Experimental Biology,
Huntingdon Life Sciences UK