ImmunoTox Letter
ImmunoTox Letter Digest■September 12, 2014 (Friday)
・Special lecture 1:
Dr. Marc Pallardy (Université Paris-Sud)

The 21th Annual Meeting of JSIT 2014
(Japanese Society of Immunotoxicology)

・Special lecture 2:

September 11 – 12, 2014

・Workshop:

Dr. Tatsuyoshi Kawamura (University ofYamanashi, Faculty of Medicine)

Tokushima Bunri Unversity, International Conference

Immunotoxicology Methods

Hall, 180 Yamashiro-cho, Tokushima, Japan.

Dr. Tomoaki Inoue

http://p.bunri-u.ac.jp/jsit2014/

Dr. Motoko Fukui
Dr. Reiko Adachi
Dr. Risako Nishino

President:
Prof. Seiichiro Himeno, Tokushima Bunri University,

・Oral / Poster presentation

Faculty of Pharmaceutical Sciences

・Awards ceremony

Secretariat:
Hitomi Fujishiro, Tokushima Bunri University, Facultyof Pharmaceutical Sciences

JSIT prize for encouragement

Phone: +81-602-8460
Fax: +81-655-3051

Nano-safety science for sustainable
nanotechnology

Deadline for abstract submission: July 10, 2014
The theme for this Meeting:

A Step forward in

Yasuo Yoshioka

Imunnotoxicological Studies

Laboratory of Toxicology and Safety Science, Graduate Schoolof Pharmaceutical Sciences, Osaka University

Program (Tentative Schedule)■September 11, 2014 (Thursday)・Educational lecture:My name is Yasuo Yoshioka from the Graduate Schoolof Pharmaceutical Sciences, Osaka University. It is myDr. Yoshiyuki Minegishi (The university ofgreat pleasure and honor to be awarded the JSIT prize forTokushima, Institute for Genome Research)encouragement. I would like to sincerely thank all of the・Symposium:
Next-generation Approach in Immunotoxicology
Dr. Atsushi Mochizuki

members of the awarding committee.
With the recent development of nanotechnology,nanomaterials are beginning to be used on a global scale.

Dr. Naoki Kanoh

However, the increasing use of nanomaterials has raisedDr. Koro Goto

public concerns about the potential risks to human

Dr. Ken Ishi

health. Because nanomaterials have the potential to・Award lecture:

improve the quality of human life, it is essential to ensure

Dr. Motoyasu Ohsawa (Hatano Research Institute,
Food and Drug Safety Center)

their safety and obtain the information for designingsafe nanomaterials. In this regards, I have attempted

・Oral / Poster presentation

to explore the field of Nano-Safety Science for the・Social gathering:sustainable nanotechnology. Especially, I have examined

Hotel Grand Palace Tokushima

the relationships between physicochemical properties,bio-distribution, intracellular localization and biologicalresponses (safety) of nanomaterials.
I recently revealed that consecutive epicutaneous
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Vol. 19 No. 1 (2014)
application of the mixture of amorphous silica

to polymorphonuclear cell infiltration, spermatic

nanoparticles and mite antigen reduce the production ofgranuloma, vasculitis, and lymphangitis. Therefore, theIgG (it is known that allergen-specific IgG suppress thetesticular tissue outside the BTB, where many resident

IgE-mediated allergic response) and induce IgE-mediatedmacrophages are normally present, is also protected

hypersensitivity in mice. My results suggested allergy-from attack by the body's immune system. To maintaininducing nanomaterials did not simply work allergenthe testicular immune privilege, the testicular cells

carrier when exposed through epicutaneous route. I

express and secrete numerous immunoregulatory

believe that this information may prove critical in aiding

molecules, including androgens, macrophage migration

progression of the nanotechnology industry, allowing it toinhibitory factor, activin, Fas ligand, protein S, andrealize the great benefits it promises.

immunosuppressive cytokines such as interleukin (IL)-10,Finally, I would like to give an appreciation to Dr. Yasuo

IL-35 and transforming growth factor (TGF)-β, which

Tsutsumi at Osaka University, and all my collaboratorsplay critical roles in regulating immune responses infor their help.

the testes. If the BTB is severely damaged, then theSincerely,

autoimmunogenic spermatozoa leak out beyond the BTB,

Yasuo Yoshioka

causing a continuous supply of autoantigens and resultant
testicular inflammation.
High dose exposure to Di-(2-ethylhexyl) phthalate

シリーズ
Young powerfor immunotoxicological research「免疫毒性研究の若い力」11(DEHP), widely used as a plastic plasticizer for syntheticpolymers, causes testicular atrophy with spermatogenesis

Reproductive immunology andImmnotoxicology

disturbance in mice and rats. Some studies haveshown that DEHP is rapidly metabolized into mono2-ethylhexyl phthalate and induces spermatogenetic○Hayato Terayama, Kou Sakabe

disturbance by oxidative stress. Others have reported

Department of anatomy, Division of basic medicine, Tokai

that small vacuoles in the cytoplasm of Sertoli cells

university school of medicine

begin to appear and morphological changes in the bloodtestis barrier (BTB) can occur. And, cadmium, one ofPlease allow me to introduce myself. I received thevarious environmental toxicants, is known to suppress

Ph.D. degree in medical science from Tokyo Medical

systemic immunity and to injure the testicular capillary

University. Present, I am an anatomist working atendothelia with resultant necrosis of testicular tissues

the Department of anatomy, Tokai University Schoolin mice and rats treated with high doses. Recently,of Medicine. My areas of expertise include anatomy,

it also became evident that DEHP and cadmium canreproductive immunology, and andrology.

affect the integrity of the BTB, testicular immunity

Because spermatogenesis begins during puberty, when

and testicular interstitium, even on treatment

immune tolerance already has been established, therewith a low dose that does not induce spermatogenic

are various autoimmunogenic materials in the testes

disturbance. Small vacuoles in the cytoplasm of Sertoli

that the body's immune system recognizes as foreign.

cells were observed in the testes of DEHP low-dose

To protect autoimmunogenic spermatozoa from attack

treated mice. Also, the numbers of macrophages andby the immune system, the testes exhibit a distinctive

MHC Class Ⅱ positive cells were significantly increased

form of immune privilege. The blood–testis barrier (BTB),

with the elevated mRNA expressions of both IL-10 andformed by tight junctions of Sertoli cells, partitions

IFN-γ in the testes of DEHP low-dose treated mice.

the interstitial blood compartment of the testis fromAnd, murine intra-testicular mRNA expression of IL-6,

the adluminal compartment of seminiferous tubules.

TNF-α and IL-1β was significantly increased by thePrevious studies demonstrated aspects of the immune

CdCl2 low-dose treatment. These study demonstrated

privilege in the testes by using a local transplantationthat DEHP and CdCl2 of the low dose that does notsystem. The testicular interstitium is resistantaffect the spermatogenesis can change the testicularNo.1（11） 11

ImmunoTox Letter
immune-microenvironment. Therefore, exposure to aWords from the new board member

low dose of DEHP and CdCl 2 induces no significant

Yasuo Morimoto

disturbance of spermatogenesis, however, it does change
the immunological microcircumstances in the testis.

Dept. of Occupational Pneumology, Institute of Industrial
Ecological Sciences
University of Occupational and Environmental Health, Japan.

Words from the new executive board members

I am very honored that I take a charge of councilor

Research and society activities in toxicology

in The Japanese Society of Immunotoxicology. At first

Seishiro Hirano

I worked as a respiratory physician in University ofNational Institute for Environmental Studies

Occupational and Environmental Health, Japan for 7years and have engaged in researches of prevention

I would like to look back when I first joined Theof occupational respiratory disease and risk/hazard

Japanese Society of Immunotoxiology instead of justassessment of respiratory materials. From 10 years

saying

It wasago, I started to perform the researches of effect ofkind of state-of-art to investigate changes in cytokine

nanomaterials on the human body. I have performed inconcentrations in toxicology in mid 1980s. I remember

vivo studies using dispersed nanomaterials through theI will do my best for the society.

that I measured murine serum TNFα concentrations

collaboration of specials agencies such as measurementby bioassay using L-N cells, because the ELISA kits

and exposure of nanomaterials. It is very important towere expensive then.

At that time I felt that senior

perform the reliable in vivo and in vitro studies whichscientists, who were responsible for scientific societies

sufficiently reflect the effect on human, and I think that I

and communities, were very active in their own research,intend to push on for studies and education of preventive

publishing papers, and education of junior scientists, andmedicine through establishment of these in vivo and in

so still I feel. Now I am afraid that toxicological research

vitro studies.

activities in this country are not good enough comparedto twenty years ago. One of the best ways to promote

I will make lots of effort in order to advance theconference.

toxicological research activities is to encourage younger
scientists who belong to the society as many seniorscientists may consider.

The achievement awards for

Words from a new board member

young scientists are provided in many scientific societies,
but still those societies may not look attractive enough

Yoshiro Saitofor them. I feel somehow whether each senior scientist

Div. Medicinal Safety Science, National Institute of Healththese days is really a role model for younger scientists

Sciences

as I felt twenty years ago. It was time to re-activatesenior scientists along with promoting young scientists
research interest in immunotoxicology.

This is my great pleasure to introduce myself
as a new board member of the Japanese Societyof Immunotoxicology.

As a successor of the current

President Prof. Takahiko Yoshida, I have been in chargeof accounting from Oct. 2013. Through this responsibility,
I would like to contribute to run the Society's activities
smoothly.
In my laboratory, we are mainly studying on
identification of biomarkers for drug-induced severe
adverse reactions (SARs) and on their onset mechanisms.
Because of their seriousness, sometimes leading toNo.1（12） 12

Vol. 19 No. 1 (2014)
death, SARs are one of the important issues in drug

been hospitalized for SLE. All I knew was this diseasedevelopment and its proper use in the post-marketingis an autoimmune disease that may cause

phase.

erythemaImmune reactions have been suggested to beandbutterfly

glomerulonephrosis . She, energetic

involved in the pathogenesis of some SARs suchyoung girl said to me how hard and tedious it was to stayas Stevens-Johnson syndrome and toxic epidermal

just home or hospital to avoid sunlight and fatigue, withnecrolysis. Drug-specific HLA genotypes are associateda little oppositional attitude. I realized the differencewith these severe cutaneous reactions, reported frombetween knowing the symptom from a book and facing toseveral groups including us, and recently, non-covalent

the real human case.

and direct drug binding with the HLA molecules isSince I moved to the present institute, I could haverevealed to be recognized as non-self by CD8 T cells,

an experience of working with Drs. Reiko Teshima,

resulting in severe reactions. We will continue to analyze

Reiko Adachi and Tomoko Mogami in the field of

the immune-related SARs in order to reduce theirimmunotoxicity, which is very impressive withincidence rates in Japan.

fascination and complexity.

+Because of the wide coverage of target materials,

As we all know, many people are suffering from immune

the Society have been an exciting place fordiseases related to the immunotoxicity, at least inimmunotoxicologists.

I would like to contribute topart. Thus, the assessment of suspected substance, thethe Society through promoting this kind of active

elucidation of mechanisms and the method of prevention

interactions, which will lead to raise the levels ofof these diseases have been desired to be revealed.
I know my experience is very limited, however, I would

Japanese immunotoxicological studies.

like to do my best to contribute for this society and its
aim. I will greatly appreciate your further guidance andWords from a new councilor

encouragement.

Greeting to becoming a newcouncilor member
Kumiko Ogawa
Pathology, National Institute of Health Sciences

First of all, I would like to express my sincere gratitude
to the doctors and the seniors who recommended andaccepted me as a councilor member of the JapaneseSociety of Immunotoxicology.
Since I graduated from Nagoya City University in 1988,
I had engaged in the histopathological and molecularpathological researches on carcinogenesis mostly usingrodents, as well as surgical pathology under the guidanceof Drs. Nobuyuki Ito and Tomoyuki Shirai of the firstdepartment of Pathology, Nagoya City University. After
I moved to the Pathology division of Biological Safety
Research Center in National Institute of Health Sciences,
I have participated in the studies and experiments
regarding toxicity and safety of substances.
My first contact of immunological disease washappened when I was a university student who did notknow anything. I met the high school girl, who had
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