シンポジウム

第 1 日目11 月 28 日（水）シンポジウムシンポジウム第1日目11月28日（水）1S-01

9:00-11:15【E】

第１日目

Room 1 (1F Main Hall)
Development of novel technologies derived from genome editing
Organizer：Takashi Yamamoto (Hiroshima University)

1S-01-1

【9:00】

MMEJ-mediated genome editing in cultured cells and animals
Takashi Yamamoto（Hiroshima University）

1S-01-2

【9:15】

Precise human disease allele creation and correction through microhomology-mediated end joining

Knut Woltjen1, Shin-Il Kim1, Janin Grajcarek1, Harunobu Kagawa1, Mitchell Braam2, Fabian Oceguera-Yanez1,
2 1
Center for iPS Cell Research and Application (CiRA), Kyoto
Mitsujiro Osawa1, Cantas Alev1, Timothy J. Kieffer（
University, Japan, 2University of British Columbia, Canada）

1S-01-3

【9:45】CRISPR-Cas-mediated targeted genome editing in human cells

3 1
Tomoji Mashimo1,2, Hiroyuki Morisaka3,4, Kazuto Yoshimi1,2, Junji Takeda（
GERDC, Grad Sch of Med, Osaka Univ,
2
IEXIS, Grad Sch of Med, Osaka Univ, 3Dept of Genome Bio, Grad Sch of Med, Osaka Univ, 4Dept of Dermat, Kochi
Med Sch, Kochi Univ）

1S-01-4

【10:15】
Identidication of cell penetrating peptide and its application to a protein-based cellular engineering forcell therapies
2 1
Yukihito Ishizaka1, Tomoki Takashina1, Tetsushi Sakuma2, Takashi Yamamoto（
Dept of Intractable Dis, NCGM,
2
Dept of Math Life Sci, Hiroshima Univ）

1S-01-5

【10:45】

DNA memory biology

Nozomu Yachie（The University of Tokyo）

1S-02

9:00-11:15【E】

Room 2 (3F 301)
Molecular Mechanisms for Cell Division
Organizer：Tatsuo Fukagawa (Osaka University)
Co-chair：Iain Cheeseman (Whitehead Institute for Biomedical Research, MIT)

1S-02-1

【9:00】

Toward the development of a “next-generation” mitotic chromatid reconstitution assay
Keishi Shintomi, Tatsuya Hirano（Chromosome Dynamics Laboratory, RIKEN）

1S-02-2

【9:20】A mechanism that ensures completion of DNA replication in pluripotent stem cells
Yasunao Kamikawa, Tomomi Tsubouchi（National Institute for Basic Biology）

1S-02-3
Mechanisms of dynein-based force generation at the cell cortex and spindle poles during metaphase【9:36】Tomomi Kiyomitsu（Nagoya University）

1S-02-4
Mechanism of cell division in plants【9:52】

Gohta Goshima（Nagoya University）

1S-02-5
Spatial control of time during chromosome segregation【10:13】

Helder Maiato1, Olga Afonso1,2（1i3S- Institute for Research and Innovation in Health, University of Porto, 2IBMC Institute for Cell and Molecular Biology, University of Porto）

68

第 41 回日本分子生物学会年会

シンポジウム

第 1 日目11 月 28 日（水）Dynamics of CCAN-KMN interaction in vertebrate kinetochore during mitotic progression【10:34】Masatoshi Hara, Mariko Ariyoshi, Tetsuya Hori, Tatsuo Fukagawa（FBS, Osaka Univ.）

1S-02-7

Iain Cheeseman（Whitehead Institute）

1S-03

9:00-11:15【E】

Room 3 (3F 302)
Non-coding DNA tells the past, the present and the future
Organizer：Takehiko Kobayashi (The University of Tokyo)

Introduction

【9:00】

1S-03-1

【9:05】

Non coding transcription regulates stability and copy number of the ribosomal RNA gene

1 1
Takehiko Kobayashi1,2, Shun Hosoyamada1, Tetsushi Iida1, Mariko Sasaki（Inst for Quantitative Biosciences (IQB),
Univ of Tokyo, 2CRIIM, Univ of Tokyo）

1S-03-2

【9:25】
Amplification of new satellite DNA and co-option of existing satellite DNA coordinately drive adaptation of
owl monkeys to nocturnal lifestyle
Akihiko Koga（Primate Inst, Kyoto Univ）

1S-03-3
Impacts of DNA break formation at non-coding genome on genome rearrangements【9:50】

Kunihiro Ohta（Dept. of Life Sciences, The Univ. of Tokyo）

1S-03-4
Gene domestication from retrotransposons contributed to Mammalian evolution1

2 1【10:15】

2

Fumitoshi Ishino , Tomoko Kaneko-Ishino（ Med Res Inst, TMDU, Sch of Med, Tokai University）

1S-03-5
Epigenetic variation in Arabidopsis【10:40】Magnus Nordborg（Gregor Mendel Institute, Austrian Academy of Sciences）

Conclusion
1S-05

Room 5 (3F 304)
New Principles of Morphogenesis, unraveled by advanced multidisciplinary approach【11:10】
9:00-11:15【E】

Organizer：Tohru Ishitani (Gunma University)

Introduction

【9:00】

1S-05-1

【9:01】

From the pattern formation to the 3D shape construction
Shigeru Kondo（Frontier Bioscience, Osaka University）

1S-05-2

【9:22】
Phase separation and flow of tight junction components are required for tight junction formation andmaturation
Carl-Philipp Heisenberg（IST Austria）

1S-05-3
Spatio-temporal fate coordination in skin homeostasis【9:48】

Kyogo Kawaguchi（RIKEN BDR・Noneq biophys）

The 41st Annual Meeting of the Molecular Biology Society of Japan

69

第１日目

【10:54】
From hibernation to proliferation: Modulating centromere and kinetochore function across cell state

シンポジウム

1S-02-6シンポジウム

第 1 日目11 月 28 日（水）シンポジウム1S-05-4

【10:09】Intracellular pH gradient: A novel player involved on the vertebrate embryo patterning

第１日目

Masayuki Oginuma1,2, Yukiko Harima2,3, FengZhu Xiong2, Olivier Pourquié2,3（1Lab of Integrated Signaling Systems,
Department of Molecular Medicine Institute for Molecular & Cellular Regulation, Gunma University, 2Departmentof Genetics, Harvard Medical School and Department of Pathology, Brigham and Women’s Hospital, 3Harvard Stem
Cell Institute, Harvard University）

1S-05-5
Extracellular fluid dynamics regulates spatiotemporal distribution of secreted proteins in Xenopus
embryos【10:30】Hidehiko Inomata, Kaori Niimi（RIKEN BDR, Axial Pattern Dynamics Team）

1S-05-6

【10:51】

Skeletal Muscle Regeration Approached from Spatial Transcriptomics

Yasuyuki Ohkawa（Medical Institute of Bioregulation, Kyushu University）

Discussion

【11:12】

1S-15

9:00-11:15【E】

Room 15 (5F 501)
Cutting edge biology led by plant models
Organizer：Tetsuya Higashiyama (Nagoya University)

Introduction

【9:00】

1S-15-1

【9:05】

Gene functions in natura - approaches using machine learning and mutants to analyze phenome,transcriptome and ecological data in naturally fluctuating environments

Kentaro K. Shimizu1,2, Reinhold Stockenhuber1, Reiko Akiyama1, Nicolas Tissot3, Michele Wyler1, Alex Widmer4,
Roman Ulm3, Jianqiang Sun5, Jun Sese5, Rie Shimizu-Inatsugi1, Toshiaki Tameshige2, Aya Tonouchi6, Natsumaro
Kutsuna6, Kenta Tanaka7, Hiroshi Kudoh8, Yasuhiro Sato9, Atsushi Nagano J9, Eri Yamasaki1, Roman Briskine1,
Tomoaki Nishiyama10, Tomonori Kume11, Kaya Usun Shimizu12, Iku Asano13, Takao Itioka13, Shin Nagai14, Misako
1 1
Dept Evol Biol Env Studies, Univ Zurich, 2Kihara Inst Biol Sci, Yokohama City Univ, 3Dept Bot Plant
Yamazaki（
Biol, Univ Geneva, 4ETHZ, 5Artificial Intelligence Research Center, AIST, 6LPixel, Inc., 7Sugadaira, Tsukuba Univ,
8
Center Ecol Res, Kyoto Univ, 9Fac Agr, Ryukoku Univ, 10Adv Sci Res Cen, Kanazawa Univ, 11Fac Agr, Kyushu
Univ, 12Fac Life Env Sci, Shimane Univ, 13Grad Sch Human Env Studies, Kyoto Univ, 14JAMSTEC）

1S-15-2

【9:30】

LZY-RLD interaction plays a crucial role in gravity signaling in Arabidopsis root gravitropism

Miyo Terao Morita1, Masahiko Furutani2, Takeshi Nishimura1, Chiemi Kondo4, Moritaka Nakamura1, Masatoshi
3 1
NIBB, 2Fujian Agr Forest Univ, 3NAIST, 4N/A）
Taniguchi4, Yoshinori Hirano3, Toshio Hakoshima（

1S-15-3
Is there a role of transgenerational epigenetic inheritance in adaptation?

【9:55】

Marc W Schmid1, Christian Heichinger1, Diana Coman-Schmid1, Daniela Guthörl1, Lindsay Turnbull2, Bernhard
1 1
Dept of Plant and Microbial Biology, University of Zurich, Switzerland, 2Dept ofSchmid2, Ueli Grossniklaus（
Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland）

1S-15-4
Evolution of carnivory in plants【10:20】Mitsuyasu Hasebe（National Institute for Basic Biology）

1S-15-5
Species Recognition in Fertilization and Its Manipulation【10:45】

Tetsuya Higashiyama（ITbM, Nagoya University）

Conclusion

70【11:10】

第 41 回日本分子生物学会年会

シンポジウム

第 1 日目11 月 28 日（水）Room 16 (5F 502)
Direct reprograming -artificial cell generation and its application-

9:00-11:15【E】

Organizer：Kinichi Nakashima (Kyushu University)
Co-chair：Soeren Leinkamp (University Medical Center Freiburg)【9:00】

Mechanistic insight of NeuroD1-induced microglia-neuron lineage switch

Kinichi Nakashima（Graduate School of Medical Sciences, Kyushu University）

1S-16-2

【9:27】

Direct reprogramming to hepatic and intestinal lineages

Atsushi Suzuki（Div of Organo & Regene, Med Inst of Bioreg, Kyushu Univ）

1S-16-3

【9:54】

In vivo reprogramming drives Kras -induced cancer development

Yasuhiro Yamada（Center for Experimental Medicine and Systems Biology, Institute of Medical Science,
University of Tokyo）

1S-16-4

【10:21】

Direct reprogramming, cardiovascular differentiation, and regeneration

Masaki Ieda（Department of Cardiology, Faculty of Medicine, University of Tsukuba）

1S-16-5

【10:48】

Direct reprogramming of fibroblasts to induced renal tubular epithelial cells (iREC)

Michael Kaminski, Roman Pichler, Jelena Tosic, Gerd Walz, Sebastian Arnold, Soeren Leinkamp（University
Medical Center Freiburg, Germany）

1S-17

Room 17 (5F 503)
Bioimaging: From Molecule to Tissue

9:00-11:15【E】

Organizer：Yoshie Harada (Osaka University)
Co-chair：Madoka Suzuki (Osaka University)

1S-17-1
Thermal response and thermogenesis at the single-cell and sub-cellular levels【9:00】

Madoka Suzuki1,2（1Inst for Protein Res, Osaka Univ, 2PRESTO, JST）

1S-17-2
Bioimaging and Biosensing with Fluorescent Nanodiamonds in Cells【9:20】

Huan-Cheng Chang（Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan）

1S-17-3
Label-Free Detection of Chemical Substances inside a Cell using Raman Imaging: Especially for the
Detection of Water in a Cell

【10:00】

Takakazu Nakabayashi（Graduate School of Pharmaceutical Sciences, Tohoku University）

1S-17-4
Manipulating living systems by light【10:25】Moritoshi Sato（Graduate School of Arts and Sciences, The University of Tokyo）

1S-17-5
Video imaging of proteins at work by high-speed atomic force microscopy【10:50】Noriyuki Kodera1,2, Toshio Ando1,2（1WPI NanoLSI, Kanazawa Univ., 2CREST, JST）

The 41st Annual Meeting of the Molecular Biology Society of Japan

71

第１日目

1S-16-1

シンポジウム

1S-16

シンポジウム

第 2 日目11 月 29 日（木）第2日目11月29日（木）2S-01

9:00-11:15【E】

Room 1 (1F Main Hall)
Supramolecular world revealed by Cryo-EM
Organizer：Osamu Nureki (The University of Tokyo)

2S-01-1

【9:00】

Cryo-EM structure of the volume-regulated anion channel LRRC8A

シンポジウム 第２日目

Osamu Nureki1, Go Kasuya1, Takanori Nakane1, Tomohiro Nishizawa1, Takeshi Yokoyama2, Mikako Shirouzu2,
1 1
The University of Tokyo, 2RIKEN）
Masahide Kikkawa1, Ryuichiro Ishitani（

2S-01-2

【9:27】

Structural basis of cellular transcription by RNA polymerase II
Shun-ichi Sekine（RIKEN BDR）

2S-01-3

【9:54】

Supramolecular Basis of Light Harvesting and Its Regulation in Plants

Zhenfeng Liu（National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences）

2S-01-4

【10:21】

Cryo-EM for intercellular communication channels
1,2 1

2

Atsunori Oshima （ CeSPI, Nagoya Univ., Dept of Pharm Sci., Nagoya Univ.）

2S-01-5
Combination of cryo-electron microscopy and genetics for studying eukaryotic cellular structures【10:48】Masahide Kikkawa（Graduate School of Medicine, The Univ. of Tokyo）

2S-02

9:00-11:15【E】

Room 2 (3F 301)
Stemness and metabolism for cancer malignancy
Organizer：Atsushi Hirao (Kanazawa University)

Introduction

【9:00】

2S-02-1

【9:03】

Diet-induced stress and homeostasis maintenance in hematopoietic stem cells

Yuko Tadokoro, Atsushi Hirao（Div of Mol Genet, Cancer Res Inst, Kanazawa Univ）

2S-02-2

【9:23】The role of gut microbial metabolites in obesity-associated liver cancer development via gut-liver axis

1 1
Tze Mun Loo2, Fumitaka Kamachi1, Naoko Ohtani（
Dept. Pathophysiol. Osaka City Univ. Grad. Schl. Med., 2Div.
Cell. Senes. Cancer Inst. JFCR）

2S-02-3

【9:43】

Diet, Metabolism and Cancer

Jing Chen（Winship Cancer Institute, Emory University）

2S-02-4
Revisiting glucose metabolism in cancer: lessons from a Pkm knock-in model【10:08】

Nobuhiro Tanuma（Miyagi Cancer Center Research Institute）

2S-02-5
Reprogrammed branched-chain amino acid metabolism in myeloid leukemia【10:28】

Takahiro Ito（Dept of Biochem & Mol Biol, Univ of Georgia）

2S-02-6
Exploring the beneficial and detrimental implications of lymphoma cell senescence in vivo

【10:48】Clemens A Schmitt（Charite - University Medical Center and Max-Delbruck-Center for Molecular Medicine Berlin,
Germany）

Conclusion

72【11:13】

第 41 回日本分子生物学会年会

シンポジウム

第 2 日目11 月 29 日（木）2S-03

Room 3 (3F 302)
Cell cooperation through organelle sharing

9:00-11:15【E】

Organizer：Ken Sato (Gunma University)
Co-chair：Mitsunori Fukuda (Tohoku University)

Introduction

【9:00】

2S-03-1

【9:03】

2 1
Miyuki Sato1, Ken Sato（Lab. of Mol. Memb. Biol., IMCR, Gunma Univ., 2Lab. of Mol. Traffic, IMCR, Gunma Univ.）

2S-03-2

【9:28】

Regulation of lysosome activity during C. elegans larval development

2 1
Rui Miao1,2, Xin Wang3, Meijiao Li3, Chonglin Yang3, Xiaochen Wang（
National Institute of Biological Sciences,
Beijing, China, 2Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, 3College of Life Sciences,
Yunnan University, China）

2S-03-3

【9:58】

Mechanisms underlying upregulation of exosomes in cancer cells

Chitose Oneyama1,2（1Div of Cancer Cell Regulation, Aichi Cancer Ctr Res Inst, 2JST PRESTO）

2S-03-4

【10:23】
Melanosome transfer and plasma membrane dynamics of melanocytes during skin pigmentation in thechicken embryonic skin
Ryosuke Tadokoro（Division of Biological Science Graduate School of Science, Kyoto University）

2S-03-5
Analysis of melanosome transfer and transport mechanisms by M-INK, a novel tool for visualizing
melanosomes【10:48】Mitsunori Fukuda（Laboratory of Membrane Trafficking Mechanisms, Graduate School of Life Sciences, Tohoku
University）

Conclusion
2S-05

Room 5 (3F 304)
Ultimate understanding of cell competition【11:13】
9:00-11:15【E】

Organizer：Yasuyuki Fujita (Hokkaido University)
Co-chair：Tatsushi Igaki (Kyoto University)

2S-05-1
Mechanisms and roles of tumor-suppressive cell competition【9:00】

Tatsushi Igaki（Graduate School of Biostudies, Kyoto University）

2S-05-2
Regulation of cell fitness by cell competition during early mouse development【9:27】

2 1
Rodriguez A Tristan1, Sarah Bowling1,2, Aida di Gregorio1, Salvador Perez Montero1, Jesus Gil（
National Heart andLung Institute, Imperial College London, United Kingdom, 2London Institute of Medical Sciences MRC, Imperial
College London, United Kingdom）

2S-05-3
Cell competition corrects noisy Wnt morphogen gradient to achieve robust patterning【9:54】

Tohru Ishitani, Yuki Akieda, Shohei Ogamino（IMCR, Gunma University）

2S-05-4
Reverse Engineering cell competition【10:21】

Charras Guillaume（University College London, UK）

The 41st Annual Meeting of the Molecular Biology Society of Japan73

シンポジウム 第２日目

The autophagy receptor ALLO-1 and the TBK1/IKKε-related kinase regulate clearance of paternal
mitochondria in C. elegansシンポジウム

第 2 日目11 月 29 日（木）2S-05-5

【10:48】Cell competition between normal and RasV12-transformed epithelial cells
Yasuyuki Fujita（Institute for Genetic Medicine, Hokkaido University）

2S-15

9:00-11:15【E】

Room 15 (5F 501)
Developmental Organology
Organizer：Ryuichi Nishinakamura (Kumamoto University)

シンポジウム 第２日目

2S-15-1

【9:00】

Building the kidney from pluripotent stem cells

Ryuichi Nishinakamura（Institute of Molecular Embryology and Genetics, Kumamoto University）

2S-15-2

【9:25】

Single-cell transcriptome and morphogenesis of developing trachea

Mitsuru Morimoto（RIKEN Center for Biosystems Dynamics Research, Laboratory for Lung Development）

2S-15-3

【9:50】

Translational Embryology Towards Therapy -from human liver organoid experience-

Takanori Takebe1,2,3（1Tokyo Medical and Dental University (TMDU), 2Yokohama City University (YCU), 3Cincinnati
Children's (CCHMC)）

2S-15-4
Establishment of perfusable vascular network for understanding multicellular pattern formation【10:15】

Takashi Miura（Graduate School of Medical Sciences, Kyushu University）

2S-15-5

【10:40】Organ Regeneration and Anti-Aging Strategies

Juan Carlos Izpisua Belmonte（Salk Institute for Biological Studies. La Jolla California）

2S-16

9:00-11:15【E】

Room 16 (5F 502)
T cell repertoire, of mice and men: Competence and tolerance
Organizer：Yousuke Takahama (National Institutes of Health, USA)
Co-chair：Taku Okazaki (Tokushima University)

2S-16-1
Molecular basis for thymic selection of an MHC-restricted T cell receptor (TCR) repertoire1

1

2【9:00】

2 1

Alfred Singer , Francois Van Laethem , Jinghua Lu , Peter Sun（ National Cancer Institute, Bethesda, Maryland
USA, 2National Institute of Allergy and Infectious Diseases）

2S-16-2
The role of thymic cortical epithelial cells in positive selection of CD8 T cells【9:30】

Yousuke Takahama（Experimental Immunology Branch, CCR, NCI, NIH, USA）

2S-16-3
The Thymus Medulla and T-cell Tolerance Mechanisms【9:55】

Graham Anderson, Emilie Cosway, Andrea White, Abdullah Alawam, Kieran James, Beth Lucas, Sarah Inglesfield,
Sonia Parnell, William Jenkinson（University of Birmingham, United Kingdom）

2S-16-4

【10:20】LAG-3 regulates immunodominance and autoimmunity by its conformation-dependent recognition of
MHCII
Taku Okazaki, Takumi Maruhashi, Il-mi Okazaki, Daisuke Sugiura, Kenji Shimizu（Div Immun Reg, Inst Adv Med
Sci, Tokushima Univ）

2S-16-5
Standing on the shoulders of mice: adventures in human immunology【10:45】

Mark Davis1,2,3,4（1Howard Hughes Medical Institute, 2Institute for Immunity, Transplantation and Infection,
3
Immunology Program, 4Department of Microbiology and Immunology, Stanford University School of Medicine,
Stanford, CA）

74

第 41 回日本分子生物学会年会

シンポジウム

第 2 日目11 月 29 日（木）2S-17

Room 17 (5F 503)
Metabolic organ network in homeostasis and pathobiology

9:00-11:15【E】

Organizer：Yoshihiro Ogawa (Kyushu University / Tokyo Medical and Dental University)
Co-chair：Ichiro Manabe (Chiba University)

Introduction

【9:00】

2S-17-1

【9:02】

Yoshihiro Ogawa1,2,3（1Dept of Med Bioregul Sci, Kyushu Univ, 2Dept of Mol Cellular Metab, Tokyo Med Dent Univ,
3
AMED-CREST）

2S-17-2
Neuronal Information Highways for Maintaining Metabolic Homeostasis at the Whole-Body Level【9:24】

Hideki Katagiri（Dept of Metab & Diabet, Tohoku University）

2S-17-3
Gateway reflex, a new concept of local neuro-immune interaction【9:46】

Masaaki Murakami（Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine,
Hokkaido University）

2S-17-4
Vagal regulation of hepatic glucose metabolism and its disorder【10:08】Hiroshi Inoue（Institute for Frontier Science Initiative, Kanazawa University）

2S-17-5
Molecular interconnections in metabolism and atherosclerosis【10:30】Minna Woo（University of Toronto）

2S-17-6
NeuroImmunoMetabolic regulation of cardiac homeostasis and heart failure【10:52】Ichiro Manabe（Dept Dis Biol Mol Med, Chiba Univ）

Conclusion

The 41st Annual Meeting of the Molecular Biology Society of Japan【11:14】75

シンポジウム 第２日目

Lifestyle-related diseases viewed through metabolic organ networkシンポジウム

第 3 日目11 月 30 日（金）第3日目11月30日（金）3S-01

Room 1 (1F Main Hall)
Cell fate determination in aging organs: stem cell aging vs. cellular senescence

9:00-11:15【E】

Organizer：Emi Nishimura (Tokyo Medical and Dental University)
Co-chair：Eiji Hara (Osaka University)

Introduction

【9:00】

3S-01-1

【9:02】

Cellular senescence: a double-edged sword in the fight against cancer

Eiji Hara1,2（1Research Institute for Microbial Diseases, Osaka University, 2Cancer Institute, Japanese Foundation forCancer Research）

3S-01-2

【9:27】

Paracrine functions of cellular senescence in cancer development

Ittai Ben-Porath（The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel）

3S-01-3
シンポジウム 第３日目

【9:52】

Metabolic regulation of hematopoietic stem cells and their niche during aging

Keiyo Takubo（Dept Stem Cell Biol, National Center for Global Health and Medicine Research Institute）

3S-01-4

【10:17】

Stem cell dynamics in mammalian skin: a clue for organ aging

Emi Nishimura（Medical Research Institute, Tokyo Medical and Dental University）

3S-01-5

【10:42】

Stem Cell Aging in Human Intestines

Toshiro Sato, Kosaku Nanki, Mariko Shimokawa, Masataka Fujii（Keio University School of Medicine）

Discussion

【11:07】

Conclusion

【11:14】

3S-02

9:00-11:15【E】

Room 2 (3F 301)
Trans-omic analysis resolves metabolic adaptation
Organizer：Tatsuhiko Tsunoda (Tokyo Medical and Dental University)
Co-chair：Shinya Kuroda (The University of Tokyo)

3S-02-1

【9:00】

Trans-omic and trans-species analysis drives precision medicine

Tatsuhiko Tsunoda（Dept of Med Sci Math, Tokyo Med & Dent Univ）

3S-02-2

【9:25】

Decoding genome-wide associations by trans-omics

Katsuyuki Yugi1,2,3,4, Tatsuhiko Tsunoda1,5,6, Shinya Kuroda4,6（1RIKEN IMS, 2PRESTO, JST, 3Inst Adv Biosci, Keio
Univ, 4Dept of Biol Sci, Univ of Tokyo, 5Med Res Inst, Tokyo Med and Dent Univ, 6CREST, JST）

3S-02-3

【9:50】

Widespread function of long non-coding RNAs

Piero Carninci（RIKEN Center for Integrative Medical Sciences）

3S-02-4
Mathematical trans-omics analysis towards predictive/individualized medicine【10:15】

Eiryo Kawakami, Tetsuo Ishikawa, Keita Koseki（Med Sci Innovation Hub Program (MIH), RIKEN）

3S-02-5
TBD【10:40】Nancy J. Cox（Vanderbilt University School of Medicine）

76

第 41 回日本分子生物学会年会

シンポジウム

第 3 日目11 月 30 日（金）3S-03

Room 3 (3F 302)
Tissue stem cell systems in homeostasis and regeneration

9:00-11:15【E】

Organizer：Fumiko Toyoshima (Kyoto University)
Co-chair：Aiko Sada (University of Tsukuba)

Introduction

【9:00】

3S-03-1

【9:03】Developmental origin and induction processes of hair follicle stem cells
Hironobu Fujiwara（RIKEN Center for Biosystems Dynamics Research）

3S-03-2

【9:29】

Molecular mechanisms of hair follicle stem cells function in normal homeostasis of adult skin

Tudorita (Doina) Tumbar, Prachi Jain, Sangjo Kang, Nina Li, Flora Eun, Catherine He（Molecular Biology andGenetics, Cornell University, Ithaca, NY, USA）

3S-03-3

【9:55】

Hair follicle neogenesis in adult skin3S-03-4

【10:21】

Epidermal stem cell dynamics during pregnancy

Fumiko Toyoshima（Institute for Frontier Life and Medical Sciences, Kyoto University）

3S-03-5
Epidermal regeneration mechanism by cross-talk between necrotic epithelia and bone marrowmesenchymal stem cells【10:47】

Katsuto Tamai（Det of Stem Cell Therapy Sci, Osaka University）

Conclusion
3S-05

Room 5 (3F 304)
Genome evolution through copy number changes【11:13】
9:00-11:15【E】

Organizer：Hideki Innan (The Graduate University for Advanced Studies)

3S-05-1
Overviewing the evolutionary fates of duplicate genes【9:00】

Hideki Innan（SOKENDAI）

3S-05-2
TBD【9:24】

Evan Eichler（University of Washington）

3S-05-3
Initial Sequence Maps of Endogenous Human Centromeres【9:59】

Karen Hayden Miga, Miten Jain, Hugh Olsen, Mark Akeson, David Haussler, Benedict Paten（University ofCalifornia Santa Cruz Genomics Institute）

3S-05-4
Evolution of dosage sensitive genes after whole genome duplications【10:24】

Takashi Makino（Graduate School of Life Sciences, Tohoku University）

3S-05-5
Exaptation of endogenous retroviruses as functional genes in mammalian placentas【10:41】

3 1
Takayuki Miyazawa1, So Nakagawa2, Koichi Kitao1, Kazuhiko Imakawa（
Inst for Front Life and Med Sci, Kyoto
Univ, 2Dept of Mol Life Sci, Tokai Univ Sch Med, 3Inst of Agr Sci, Tokai Univ）

The 41st Annual Meeting of the Molecular Biology Society of Japan77

シンポジウム 第３日目

Mayumi Ito（New York Univerity School of Medicine）

シンポジウム

第 3 日目11 月 30 日（金）3S-05-6

【10:58】

Identification of structural variations and analysis of their functional roles

1 1
Akihiro Fujimoto1,2, Hidewaki Nakagawa2, Hitomi Yagi1, Jing Hao Wong（
Department of Drug Discovery Medicine,
Graduate School of Medicine, Kyoto University, 2Laboratory of Genome Sequencing Analysis, RIKEN Center for
Integrative Medical Sciences）

3S-15

Room 15 (5F 501)
9:00-11:15【E】
A challenge to unveil molecular mechanisms underlying appropriate selective responses to the environmental information
Organizer：Ikue Mori (Nagoya University)

Introduction

【9:00】

3S-15-1

【9:01】A model organism in the wild: C. elegans

Marie-Anne Felix（Institute of Biology of the Ecole Normale Superieure）

3S-15-2

【9:41】

Diversity and evolution of nematode genomes

シンポジウム 第３日目

Taisei Kikuchi（Faculty of Medicine, University of Miyazaki）

3S-15-3

【10:04】
Neural circuits regulating divergent escape responses in Drosophila larvae: implication for evo-devo ofadaptive behaviors
2 1
Akinao Nose1,2, Suguru Takagi（
Dept Comp Sci, Univ of Tokyo, 2Dept Phys, Univ of Tokyo）

3S-15-4

【10:27】

Molecular mechanism for diversity of temperature preference in Drosophila species
Takeshi Awasaki（Kyorin University School of Medicine）

3S-15-5

【10:50】Innate and acquired auditory neuronal pathways for zebra finch song learning
Yoko Yazaki-Sugiyama（OIST Graduate University/ IRCN）

Conclusion
3S-16

Room 16 (5F 502)
Emergence of new RNA potentials【11:13】
9:00-11:15【E】

Organizer：Yukihide Tomari (The University of Tokyo)
Co-chair：Shin-ichi Nakagawa (Hokkaido University)

3S-16-1
Preferential association of prion-like-domain-containing RNA binidng proteins to functional lncRNA
candidates【9:00】

Shin-ichi Nakagawa（Facult. Pharm., Hokkaido Univ.）

3S-16-2
Long noncoding RNAs in brain development and glioma【9:20】

Rebecca E. Andersen, Sung Jun Hong, Martina Malatesta, S. John Liu, David Wu, Daniel Lim（University ofCalifornia, San Francisco）

3S-16-3Functional polypeptides encoded by putative long non-coding RNAs

【9:45】

Akinobu Matsumoto, Keiichi I. Nakayama（Department of Molecular and Cellular Biology, Medical Institute of
Bioregulation, Kyushu University）

3S-16-4
COMRADES reveals the Zika virus genomic structure inside human cells【10:05】

Eric Miska1,2（1University of Cambridge, 2Wellcome Sanger Institute）

78

第 41 回日本分子生物学会年会

シンポジウム

第 3 日目11 月 30 日（金）3S-16-5

【10:30】Metabolic RNA sequencing provides insights into the intracellular kinetics of small RNA silencing pathways
Stefan L Ameres（Institute of Molecular Biotechnology, IMBA, Vienna Biocenter, Austria）

3S-16-6
The 3′-end formation mechanism of silkworm piRNAs【10:55】

Natsuko Izumi1, Keisuke Shoji1,2, Yukihide Tomari1,3（1IQB, Univ of Tokyo, 2Dept of Agri, Utsunomoya Univ, 3Grad
Sch of Front Sci, Univ of Tokyo）

3S-17

Room 17 (5F 503)
Robotic Biology: hardware and software technology for accelerating life science researches

9:00-11:15【E】

Organizer：Tohru Natsume (AIST)
Co-chair：Koichi Takahashi (RIKEN)

Introduction

【9:00】

3S-17-1

【9:05】

A next generation Laboratory by effective Human-Robot Collaboration

3S-17-2

【9:25】

Current & future solutions for Robotic biology
Hirotaka Ito（Tecan Japan, Co., Ltd.）

3S-17-3
Automated live single-cell imaging analysis with single-molecule sensitivity【9:45】

Masahiro Ueda1,2（1Graduate School of Frontier Biosciences, Osaka University, 2RIKEN Center for Biosystems
Dynamics Research (BDR)）

3S-17-4

【10:05】
Automated Identification of Cell Differentiation Stages using Bright Field Microscope Image and LabDroid
MAHOLO
Toutai Mitsuyama, Archana Bajpai（National Insitute of Advanced Industrial Science and Technology (AIST)）

3S-17-5
Impact of Machine Learning on Science【10:25】Hiroshi Maruyama（Preferred Networks, Inc.）

3S-17-6
The Future of the Relationship Between Biology and AI Researchers【10:45】

Koki Shimada1,2（1Dept. of Computer Science, UCL, 2SyntheticGestalt Inc.）

Conclusion

The 41st Annual Meeting of the Molecular Biology Society of Japan【11:05】79

シンポジウム 第３日目

1 1
Miho Sasamata1, Daisuke Shimojo1, Yukiko Yamagishi2, Haruna Iwaoka（
Modality Research Labs., Astellas PharmaInc., 2IRM Satellite Office, Astellas Pharma Inc.）