The 3rd Annual Meeting of JSIT
1996.9.25-26.
Kamijo Auditoriium, Showa University （Tokyo）
President: Yukio KUROIWA (School of Pharmaceutical Sciences, Showa University)
Special Lecture <1>
Immunopaahologicalaspects of chemical anddrug toxicities and risk
assessment

Joseph G. Vos

National Institute of
Public Health and theEnvironment (RIVM)

Special Lecture <2>
Mucosal Immune Systemand Immunotoxicology.

H. Nagura

Department of Pathology,
Tohoku University Schoolof Medicine.

Special Lecture <3>Safety evaluation ofbiotechnology products,
Joy A. Cavagnaro
including immunotoxicityA

Center for Biologics
Evaluation and ResearchU. S. Food and Drug
Administration

Mini-symposium
Cytokine Production byHuman Airway Eoithelial
Cells - Effects of Air Pollutants.

Dept. of Medicine andTakayuki Ohtoshi

T.Tsuda(1),Y.Morimoto(1),H.Nakamura(1), H.
Risk assessment of man Hori(2),H.Yamato(1), S.
made mineral fibers using
Ishimatsu(2), T.Oyabu(1),
RT- PCR
AFujino(1), J.Nambu(2),T.Higashi(1), I.Tanaka(1)Physical Therapy, Facultyof Medicine, University ofTokyo(1)Institute of Industrial
Ecological Sciences,(2)University ofOccupational
Environmental Health,Japan.

Workshop
CollaborativeImmunotoxicologicalStudy by Fourteen - day
Oral Administration of
Cyclophoshamide - Organweight and Histo pathology -Y. Okamoto(1), Y.Kawachi(2),S. Kono(3), A. Ozaki(4), K.
Amano(5), R. Suzuki(6),D.Nakatsuka(7), K.
Taguchi(7), K. Nagami(8), K.
Yuasa(9), D. Nagai(10), K.
Nakamura(11)Collaborative
ImmunotoxicologicalStudy by Fourteen - day
Oral Administration of
Cyclophosphamide Spleen Cellularity andFlow Cytometry -K. Nakamura(1), Y. Kouchi(2),A. Ozaki(3), H. Tsutsui(4), R.
Suzuki(5), S. Kawano(6), Y.
Amano(7), D. Nakatsuka(8),K.
Nagami(9), H. Yuasa(10),D.Nagai(11)(1)Toray, (2)Taiho,(3)Bristol - Myers Squibb,(4), Otsuka, (5)Kowa,(6), Nippon Glaxo,(7)Nippon Hoechst
Marion Roussel,(8)Banyu, (9)Tanabe,(10)Nihon Kayaku,(11)Shionogi(1)Shionogi, (2)Taiho,(3)Otsuka, (4)Mitsubishi
Chemical, (5)NipponGlaxo, (6)Bristol - Myers
Squibb, (7)Kowa,(8)Nippon Hoechst
Marion Roussel,

(9)Banyu, (10)Tanabe,(11)Nippon Kayaku
Collaborative(1)Bristol - Myers Squibb,

Immunotoxicological(2)Otsuka

Study by Fourteen - day
Oral Administration of
Cyclophos - phamide Evaluation of Humoral
Immune Response byS. Kawano(1), A. Ozaki(2), D.

Pharmaceutical,(3)Nippon Hoechst
Nakatsuka(3), K.
Marion Roussel,
Nakamura(4), T.Masuda(5), D.
(4)Shionogi,Nagai(6), M. Hayakawa(7)(5)Lederle(Japan),

Enzyme - linked
Immunosorbent Assay -(6)Nippon Kayaku,(7)Mitsui Pharmaceutical

Collaborative
ImmunotoxicologicalStudy by Fourteen - day
Oral Administration of
Cyclophosphamide Natural Killer Activity -(1)Mitsubishi Chemical,
N. Tsutsui(1), K.
(2)Shionogi, (3)TaihoNakamura(2), Y. Kouchi(3), K.
Pharmaceutical,
Nagami(4)(4)Banyu

General Presentation
Quantitative Evaluation ofPassive Cutaneous
H. Akiyama(1), R. Teshima(2),Anaphylaxis (PCA) Using R. Akasaka(2), Y. Goda(1), J.
A Hand - held
Sawada(2),M. Toyoda.
Spectrophotometer.

(1)Div. of Foods (2)Div.
of Biochemistry andImmunochemistry,
National Institute of
Health Sciences.

A prediction of chemical induced immunogenicity
Y. Kouchi, Y. Maeda, A.
using popliteal lymph
Ohuchida.
node assay.

Drug Safety
ResearchLaboratory,Taiho(1)Dept. of HygienicChemistry, Daiichi CollegeStudies on Isolation ofA.Toda(1), Y. Hisanari(1), Y.
of PharmaceuticalCarrier Protein in Primary Masuda(1), H. Shigematsu(1),Sciences. (2)Daiichi
Cultured Rat Hepatocytes. R.Eyanagi(2)University - College ofTechnology.

T. Yoshida(1), T. Hagino(1) F.
Kayama(2),(1) Dept. ofEnvironmentalHealth,Tokai University
School of Medicine、(2)Dept. ofEnvironmental Health,
Jichi Medical University.

The increase of histamine K. Ikeda, M. Taguchi, T. Sato,rlease from rat mast cells H. Nagase, H. Kito, M.
with several pesticides.
Niikawa.

Dept. of Public Health,Gifu PhamaceuticalUniversity

Effects of someantioxidants on calcium
R. Akasaka(1), R. Teshima(1),signals, degranulation and S. Kitajima(2), J. Momma(2),LTC4 release of RBL-2H3 T. Inoue(2), J. Sawada(2)cells.

(1)Div. of Biochemistry
and Immunochemistry(2)Div. of Toxicology,
National Institute ofHealth Sciences

Induction of oral
immunity and blockade ofS.Yoshino(1),M.Sagai(2)oral tolerance by diesel
exhaust particles.

(1)Dept. of Microbiology,
Saga Medical School(2)Research Team for
Health Effects of Air
Polutions, Nat. Inst. forEnvironmental Studies

Effects of low
concentration offormaldehyde on
experimentally induced
type I and Ⅳ allergy inmice.

Immunotoxicity on theM. Nagata, S. Kimura, A.

Developmental Research

Watanabe, M. Takeuchi, K.

Laboratories, Shionogi &Nakamura.

Co., Ltd.

Immunotoxicity tests in

J. Kai(1), M. Shimada(2), H.

(1)Dept. of Drug Safety

rats, Comparison of rat

Imade(1), J. Sonoda(1), Y.

Research, Eisai Co., Lid.

strain F344 with SD.

Sugihara(1), T. Mikami(1)(2)Kawashima Co., Lid.

of Cell Kinetics in theK. Toyoda, T. Shoda, C.

Division of Pathology,

Lymphoid Organs Using

Uneyama, K. Takada, M.

National Institute ofLabeling Indices of BrdU

Takahashi.

Health Sciences.

Humoral Immune
Response to Thymusindependent Antigen.

Morphological Evaluation

and TUNEL.
Esatblishment ofGranulocyte Colony
Formation Assay using SD
Rat Bone Marrow Cells.
Evalution of
immunotoxicity tests
using Dex. and CysA.

Tokushima Resarch
K. Matsumura, A. Ozaki,Institute, Otsuka
Pharmaceutical Co., Ltd.

M. Inoue, R. Nagatahira, K.
Motizuki, Y. Ito, J. Yoshida, K.
SaitohSafety ResearchLaboratories Kaken
Pharmaceutical Co., Ltd.

Effects of Interleukin - 12
T. Inoue, K. Shimura, H.
on Normal and Tumor Suzuki, I. Horii.
bearing Mice.

Dept. Toxicology andPathology, Nippon Roche
Research Center.

Immunologicalinsignificance offenitrothion in mice andrats.

T. Kunimatsu, Y. Kamitat, N.
Isobe, Y. Okuno, H. Kawasaki.

Sumitomo Chemical Co.,
Ltd., Environmental
Health ScienceLaboratory.

Evaluation of In Vitro
Toxicity of 50 MEIC
Compounds on Human
Natural Killer CellFunction.

Y. Kobayashi

Lab. Of Molecular
Immunology, Faculty ofScience, Toho University.

Effects of ethanol andacetaldehyde on Naturalkiller cell activity.
Cadmium Induces
Apoptosis in Immune
System.

C. Inoue, T. Takeuchi, T.
Takeshita, K. Morimoto.

of Medicine
M. Ishido, H. Fujimaki.

Role of Proinflammatory
Cytokines in Rat
Experimental Hepatitis
Induced by Endotoxins invitro.
Application of precision cut kidney slice culture asa model of kidney
immunotoxicologicalevaluation.

Department of Hygieneand Preventive Medicine,
Osaka University School

National Insititute forEnvironmental Studies.
Lab. of Biochem.

K. Ueno, H. Shinohara, A.
Kobayashi, K. Chiba.

F. Kayama(1), K.
Nakatsuka(1), T. Yoshida(2),Pharmacol. & Biotoxicol.,Faculty of PharmaceuticalSciences, Chiba
University(1)Dept. Environ. Health,
Jichi Med.School.,(2)Dept. Environ. Health,Tokai Univ. Sch. Med.