Immunotoxicology Specialty
Section Newsletter
P re s i d e n t ’s M e s s a g e
Jean Regal, Ph.D.
Celebrate 25 years of the ImTox SS in 2010!
Don’t miss it! Salt Lake City, March 7-11, 2010
The ImTox SS began in 1985 so 2010 is our 25th year.
In recognition, we will be celebrating at our specialty
section reception at the 2010 SOT annual meeting inSalt Lake City.
2009 - 2010
Executive Committee
President
Dr. Jean Regal
Vice President
Dr. Leigh Ann Burns Naas
Vice President-Elect
Dr. Rodney R. Dietert
Secretary-Treasurer
Dr. Jacintha M. Shenton
Past President
Dr. Jeanine L. Bussiere
Senior Councilor
Dr. Marc Pallardy
Junior Councilor
Dr. Wendy J. Komocsar
Postdoc Representative
Dr. Stacey Anderson
Student Representative
Mr. Haitian Lu
The Immunotoxicology Specialty Section
Newsletter is published three times/year (May,
August and November). If you would like toshare a book review, meeting report, web site,or any other item of interest with members of
the Specialty Section, please send it to us by
the middle of the month preceding the planned
publication date. All comments on, or
suggestions for, the newsletter are welcome.
Jacintha M. Shenton, Ph.D., Editor
jacintha.shenton@utoronto.ca (home)shentonj@medimmune.com (work)
Typesetting / desktop publishing provided by
L. Peyton Myers, Ph.D., Co-Editor

November 2009

SAVE THIS DATE and TIME:
ImTox SS Reception
Tuesday evening, March 9, 6 pm
Salt Lake City Convention Center

Dr. Jean Regal
President, ImTox SS
2009-2010

The celebration will include a slide show portraying the history of the ImTox
SS. To make the slide show grand please contribute photographs. Lookthrough your files and send any and all photographs of our members (both pastand present) to Peyton Myers (Laine.Myers@fda.hhs.gov).
SEND PHOTOS from the 80s, 90s, and today!!
Before (past) and after (present) photographs would be highly appreciated. ☺
We hope that many of the Past Presidents of the specialty section will be able
to attend the celebration so that we can recognize them for their service andproperly celebrate the past 25 years and the years to come.
Donations to support the celebration are welcome. Checks can be made out to
SOT (please indicate on the check that the monies are to support the 25th
Anniversary Celebration) and sent to the ImTox SS Secretary/Treasurer, Dr.
Jacintha Shenton, Aaron Klug Building, MedImmune, Granta Park,
Cambridge, CB21 6GH, England.
Thank you and hope to see you there,
The 25th Anniversary Celebration planning committee: Jean Regal, Leigh Ann
Burns Naas, Rod Dietert, Jacintha Shenton, Jeanine Bussiere, Dori Germolec,
Peyton Myers, Haitian Lu, and Stacey Anderson

President’s Message................................................................. pages 1-2
Committee Reports................................................................ pages 3-11
JSIT Meeting Report........................................................... pages 11-13
Announcements.................................................................... pages 14-17
Recent Immunotoxicology Publications ............................ pages 18-21
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Immunotoxicology Specialty Section

Contribute to the HESI Immunotoxicology Young Investigator Award Fund Today
Download the Endowment Donor Form here http://toxicology.org/AI/CSOT/Endowment_Donor_form.pdf or
through the link on the ImTox SS webpage http://www.toxicology.org/ISOT/SS/imtox/Index.asp andcontribute to the Health and Environmental Science Institute (HESI) Immunotoxicology Young InvestigatorAward Fund. Proceeds from the Fund will be used to assist a young investigator to attend and participate in
the annual meeting of the SOT (see the Awards Committee report within this newsletter). Thanks to HESI for
the initial contribution and Dr. Jeanine Bussiere for working so hard to get this fund established for young
immunotoxicologists within 5 years of their doctoral dissertation. What better way to encourage up andcoming immunotoxicologists to attend the SOT meeting and participate in our great specialty section.

Support for the SIEE Study Section
Thank you!! Sincere appreciation to all who took the time to send a letter of support to Dr. Garte forcontinuation of the Systemic Injury by Environmental Exposure (SIEE) Study Section for review of toxicology
grants, including immunotoxicology. Steve Pruett’s ad hoc committee (Steve Pruett, Norb Kaminski, Deborah
Keil, Paige Lawrence, Judy Zelikoff, and Prakash Nagarkatti) also formulated a strong and convincing letterfrom the ImTox SS articulating the importance of SIEE for funding the strongest immunotoxicology researchand continuing the training of immunotoxicologists.

ImTox SS Program Proposal Process Showcased
During September, SOT held a series of Leadership Connection webinars for specialty section leadership toassist the leadership in conducting the business of the specialty sections. Included in this series was a session
on program proposal preparation for the SOT annual meeting. Because of the long term success of our
specialty section in bringing great programs to the meeting, we were one of three specialty sections asked tooutline the process for generating successful SOT program proposals. Leigh Ann Burns Naas represented oursection and provided great information to the leadership of other sections on how to be successful. Thanks
Leigh Ann!

November 20092

Immunotoxicology Specialty Section

(rrd1@cornell.edu) no later than
Friday December 11th, 2009.

ProgramCommittee
ReportSubmitted by: Dr. Rod Dietert
Please send your program proposals
for the 2011 SOT annual meeting inWashington, DC, to Rod Dietert

Let's make 2011 and the 50th
Anniversary of SOT a banner year
for Immunotoxicology.

Remember they can be in the form of
Symposia, Roundtables, Continuing
Education Courses, Historical
Highlights or Informational Sessions.
A brief description of each category
is provided below:

Session Type
Symposium

Subject Matter
Recent scientific advances

Duration≤ 3 hours

Speakers
4-5 (30-35 minutes
each; Summary bylast speaker)

Workshop

Emphasis on quality presentations of generally accepted, state-of-the-art knowledge intoxicology.

≤ 3 hours

1-5

4 hr

CE: 4-5 total

Sunrise, 1 hr

Sunrise: 1
3-5 (5 min statement with balance
for discussion)Moderator and 1-3
speakers (lecture in
symposium format
with time for Q&A)

Informal, interactive presentations with emphasis on discussion
Continuing
Education

Emphasis on quality presentations of generally accepted, state-of-the-art knowledge intoxicology

Roundtable

Controversial subjects

1.5 hrHistorical

The selected topic should be broad based,
include the contributions of multiple laboratories and feature a review of a historicalbody of science that has impacted the field of
toxicology. The title should be descriptiveof the advancement that has been achieved
and/or the impact of the advancement

1.5 hr

Not based on the outcome of scientific research. Should address informational needsof members on topics such as Career Development, General Information, and Planned
Scientific Activities

1.5 or 2.75 hr(need to explain
extended timeneed)Highlight

Informational
SessionNumber depends on
duration. Short:
10-15 minutes eachwith the balance fordiscussion.
Long: 3-5

November 20093

Immunotoxicology Specialty Section

Student andPostdoctoral
ReportSubmitted by
Dr. Stacey Anderson,
Postdoctoral Representative,and Haitian Lu, Student
Representative
Greetings students and postdocs!
Exciting New Business!!!
ImTox SS 25th Anniversary
Celebration
All student and postdoc membersof the ImTox SS should havereceived an e-mail from Haitian
about the ImTox SS 25th
Anniversary Celebration. If you
did not receive this e-mail, please
send your e-mail address to the
Editor, Jacintha Shenton(shentonj@medimmune.com), sothat Jacintha can add you to the
ImTox SS student/postdoc
distribution list.
For those of you who did notreceive the e-mail, inadvertently
deleted it, or justsimply ignored it, it went like
this…

November 2009

I am writing to request yourcontributions to a slide show thatwill be presented in celebration of
the 25th Anniversary of the
ImTox SS thatwill be taking
place
atthe 2010 SOT
a n n u a lmeeting in Salt
Lake City.
A 25th anniversary task force has
been formed to plan thecelebration of this historical event
which will occur at the ImTox
SS reception (the evening of
Tuesday March 9th, 2010). The
slide show will feature past award
winners, past presidents, historicalmoments, and most importantly
us...the student and postdoctoral
members! Student andpostdoctoral members are a vital
component of our specialty
section. Therefore, we aresoliciting a personal photographor photographs picturing ourstudent and postdoc members
engaged in either SOT activities
or activities in your respective
research labs. Please also write afew sentences telling us whatmade you become interested in
immunotoxicology or choose
immunotoxicology as your major
area. These contributions will becompiled and included in the slide
show. Be a part of history!

4

Please take a few minutes to send
your photographs, the reason you
love immunotox, and any othersuggestions for the 25th
anniversary celebration to Haitian
Lu (luhaitian82@gmail.com).
Don’t make us use stickmen andwomen to represent you!

WANTED - New Student andPostdoc Representatives
Dr. Stacey Anderson completed
her term as the ImTox SS
postdoctoral representative inMarch 2009 and Haitian Lu willcomplete his term as the student
representative in March 2010.
Thus, it’s time to pass the baton to
the next generation of student andpostdoc representatives. For thoseinterested in these positions,please send your CV and anomination letter from youradvisor to Dr. Jean Regal(jregal@d.umn.edu) by Nov 30,
2009 or Dec 31, 2009 for the
postdoctoral or student representative positions, respectively.
You should first verify with youradvisor that he/she is willing tofund your travel to SOT for the
next two years. Please do nothesitate to contact Haitian(luhaitian82@gmail.com) or
Stacey (sanderson4@cdc.gov) for
more information about serving asa student or postdoctoral
representative.
Immunotoxicology Specialty Section

Student/Postdoctoral
Reminders:
Be Recognized for theStar that you Are!
Please take note of the Awards
Committee report within thisnewsletter. These awards present
opportunities for students andpostdocs to be recognized for theircontributions to the field of
Immunotoxicology.
Awardwinners will be recognized at the2010 ImTox SS reception, in the
ImTox SS newsletter, and on the
ImTox SS website.
Come ONE Come ALL!
If you missed the ImTox SS
student/postdoc mixer in
Baltimore don’t despair, there will
be a similar opportunity tosocialize at the 2010 meeting inSalt Lake City (details to follow)!
We look forward to seeing ALL
OF YOU at the 2010 mixer.
Should you have any suggestions
about other types of events, pleasefeel free to contact us, Stacey(sanderson4@cdc.gov) or Haitian(luhaitia@msu.edu).

Immunotoxicology
Pool of Lecturers
Submitted by: Dr. Judy
Zelikoff
The Immunotoxicology Pool of
Lecturers Program, which allows
faculty to invite immunotoxicology guest lecturers (seeavailable individuals below) toteach in their class, has beenrunning successfully over the last
few years. Last year, Dr. Dave
Shepherd asked for, and received,
financial support from theProgram for MaryJane Selgrade(US EPA) and Prakash Nagarkatti(Univ. of South Carolina) to teachat the University of Montana.
MaryJane lectured on“environmental pollutants andallergic lung disease”, while
Prakash discussed “immunomodulation by natural products”.
Both lectures were a huge success.

Immunotoxicology Pool of Lecturers
Judy Zelikoff (Organizer)
Leigh Ann Burns Naas
Mitch Cohen
George DeGeorge
Rod Dietert
Ken Draper
Deborah Finco-Kent
Kathleen Gilbert
Ken Hastings
Robert House
Norb Kaminski
Barb Kaplan
November 2009

If anyone is interested in having
any of our expert Immunotoxicologists (see insert box) teachin one of your classes either
during this Fall semester (2009) orin the upcoming Spring (2010)
semester, please contact Judy(judith.zelikoff@nyumc.org) assoon as possible with thefollowing information: (1) course
title and academic level (i.e.,undergraduate, graduate,
postdoctoral/medical); (2) name ofguest lecturer and the topic to bepresented; (3) amount and purposeof requested funds; and, (4) dateneeded. Once received, yourrequest will be discussed by the
ImTox SS President andSecretary/Treasurer andprioritized (if requests are madefrom multiple schools). After a
final decision is reached, you will
be notified of the decision (within
about a month) and the amount offinancial support you will receive.
The amount of funds available forany given year is related to thespecialty section budget. Monies
from the program can be used tosupport guest lecturer travel, hotel
accommodations for a single
night, and/or meals. We lookforward to hearing from you.

Nancy Kerkvliet
Ian Kimber
Raj Krishnaraj
David Lawrence
Mike McCabe
Mitzi Nagarkatti
Prakash Nagarkatti
Margie Peden-Adams
Joseph Piccotti
Helen Ratajczak
Jean Regal
MaryJane Selgrade

If you want to go on the list as aguest lecturer, please write to Judyat Judith.zelikoff@nyumc.org.
Thanks.

5

Immunotoxicology Specialty Section

Financial Report
Submitted by: Dr. Jacintha Shenton
The fiscal year runs for 12 months ending on June 30th

2008-2009
Ordinary Income/Expense
IncomeContributions
Dues
Registration
Interest

2007-2008

900
4,725
4,009
456
-------10,090--------

4,575
4,516
789
-------9,881--------

900

900

727
1,622
1,846
350
10,156-------15,602--------

741
2,700
2,351
400
4,581
-------11,674--------

Revenue over Expenses(5,512)--------(1,793)--------Net Assets Beginning of year

16,576

18,369-------11,064======-------16,576======

Total Income

ExpenseAwards - Sections
Plaques (accent engraving)
Executive Meetings
Miscellaneous
Newsletter
Reception
Total Expense

Excess (Deficiency) of

Net Assets End of YearAll entries are listed in US Dollars and are rounded to the nearest dollar. Income includes dues
(paid with your SOT membership) and registration (which is based on the number of ImTox SS
members at the SOT annual meeting).
Expenses include the Imtox SS Executive Meeting & Reception held at the SOT annual meeting, miscellaneous expenses (monies for the ImTox Pool of Lecturer's, the Japan Exchange,
and the Student/Postdoc mixer), and the newsletter (typesetting).
November 2009

6

Immunotoxicology Specialty Section

ImTox SS Membership Committee Report
Submitted by: Dr. George DeGeorge
By Organization Category

By Membership Category

NP: Not for Profit
CRO: Contract Research Organization

November 20097

Immunotoxicology Specialty Section

ImTox SS Membership Committee Report

Note: The “dip” occurs when SOT deletes those who haven’t renewed at the end of the year.

November 20098

Immunotoxicology Specialty Section

Awards
Committee
UpdateSubmitted by:
Dr. Marc Pallardy
The ImTox SS is requesting
nominations for the following
awards to be recognized at the2010 SOT annual meeting:
ImTox SS Vos Award — Career
Achievement in Immunotoxicology
This award is offered asrecognition to a Senior
Investigator whose body of work
represents an outstandinga c h i e v e m e n t i n i m m u n otoxicology. The nominator should
provide a discussion of the rolethat the individual’s work has
played in advancing the field of
immunotoxicology. A curriculum
vitae and bibliography for thenominee should also be included.
A second letter of recommendation from another investigatorin the field would be helpful.
Nominees are evaluated withrespect to the following criteria:
1) Contribution to the field of
immunotoxicology—depth andbreadth of scientific contributions
and significance of contributions
for advancing the field;
2) Major influence in the
education/training/mentorship ofyoung scientists in the field of
immunotoxicology including
November 2009training in government, industry,or academia;
3) Leadership and service to theimmunotoxicology field including
involvement in the specialty
section or other meetings/
organizations related toimmunotoxicology;4) Influence on regulatory andrisk/safety assessment decisions
related to immunotoxicology.
Nominations of unsuccessful
candidates will be considered for
two additional years unless thenomination is withdrawn by thesponsor. Final decisions will bemade by the Nominating
Committee (President, last three
Past Presidents, the Vice
President, and Vice Presidentelect).
Nominations should be submitted
by December 30, 2009 to Dr. Jean
Regal [E-mail: jregal@d.umn.edu]
ImTox SS Best Paper of theYear Award
An engraved plaque will beawarded to the author(s) of thebest paper in the area of
immunotoxicology, published in
ANY peer-reviewed journal. The
paper must have been publishedbetween July 1, 2008 and Dec 31,
2009. The nomination for thisaward should provide a fullcitation of the paper and a short
discussion of the value of theresearch to the field of
immunotoxicology. Authors may
9

not self-nominate their own
papers. Review papers are noteligible for this award.
Decisions on this award will bemade by members of the Awards
Committee, chaired by the SeniorCouncilor.
Nominations should be submitted
by February 1, 2010 to Dr. Marc
Pallardy [E-mail:marc.pallardy@u-psud.fr]
ImTox SS Outstanding Young
Immunotoxicologist Award
An engraved plaque will beawarded to the young investigator
whose body of work has madesignificant contributions to thefield of Immunotoxicology. Thisaward is NOT LIMITED to thosein academia. Investigators who
have had an impact on regulatory
issues or within industry will also
be considered.
The nominee must have less thanten years of experience sinceobtaining their highest degree.
Exceptions to the 10 year
limitation can be made if careers
have been interrupted for familyor health reasons, or clinicalpractice, etc. Reasons for the
exception should be documented
in the nomination letter.
Nominators are required to
document the contributions of thecandidate and also provide acurriculum vitae and bibliographyof the candidate. The depth,
breadth and significance of the
Immunotoxicology Specialty Section

scientific contributions of thenominee to advancing the field of
immunotoxicology should be
addressed, as well as service to theimmunotoxicology community.
All nominations of candidates thathave not received the award will
be retained and considered for an
additional 2 years unless thenomination is withdrawn by thesponsor.
Determination of the awardee willbe by the Vice President andme m b e r s o f t h e A w a r d s
Committee.
Nominations should be submitted
by January 15, 2010 to Dr. Leigh
Ann Burns Naas [E-mail:leighann.burns@pfizer.com]

We encourage you to take aminute to nominate yourpostdoctoral trainees so they canbe recognized for their work.
Nominations should be submitted
by February 1, 2010 to Dr. Marc
Pallardy [E-mail:marc.pallardy@u-psud.fr]

ImTox SS Best Presentation by
a Student Award
The award requirements are
submission of a complete writtenversion (including all graphs andtables) of an immunotoxicology
presentation to be made at the2010 SOT Annual Meeting.
•

ImTox SS Best Presentation by
a Postdoctoral Trainee Award
The award requirements are
submission of a complete writtenversion (including all graphs andtables) of an immunotoxicology
presentation to be made at the2010 SOT Annual Meeting.
This presentation is to beaccompanied by a letter of
nomination from the postdoctoral
trainee's advisor. Please utilize
electronic submissions.
No manuscripts will be accepted.

••

This presentation is to beaccompanied by a letter of
nomination from the student’s
a d v i s o r . P l e a s e ut i l i z eelectronic submissions.
No manuscripts
accepted.

The HESI Immunotoxicology
Young Investigator Travel Award
will be awarded each year to ayoung investigator who is within 5
years of receiving a Ph.D. degree.
This award was made possible
through the hard work of Dr.
Jeanine Bussiere, Past President,
and HESI. This award replaces theInternational Postdoc Award andwill provide a cash award to assist
young investigators to attend SOT
and present their research. Please
contribute to this fund and takeany advantage of employer and
SOT matching funds while they
last!.
The guidelines for this award are:•<5 years from having
completed his/her graduate
dissertation.

•

Letter from postdoctoral
advisor and/or employer
indicating the individual's past
contributions to immunotoxicology (or a closelyrelated discipline) andpotential future contributions
to the discipline.

•

Curriculum Vitae•

Letter from applicant on how
attendance at SOT willcontribute to their careerdevelopment in immunotoxicology.

beWinners will receive a plaqueand cash award

We encourage you to take aminute to nominate your students
and so they can be recognized fortheir work.
Nominations should be submitted
by February 1, 2010 to Dr. Marc
Pallardy [E-mail:marc.pallardy@u-psud.fr]

Winners will receive a plaque andcash award.

November 2009

will

ImTox SS HESI
Immunotoxicology Young
Investigator Travel Award

10

Immunotoxicology Specialty Section

•

The individual must havesubmitted an abstract and beable to attend the Annual
Meeting.

•

The abstract must be includedin the application.

•

Both U.S. and International
individuals are eligible.

•

The individual need not be amember of SOT, but those
who are members or who arein the process of becoming
members will be given
preferential consideration.

•

Selection of the recipient will
be made by a committee
consisting of the Vice
President-elect, Vice
President, President, and mostrecent three Past-Presidents.
An individual cannot be therecipient of the award morethan once.

Please submit nominations for the
HESI Immunotoxicology Young
Investigator Travel Award by
December 30 2009 to: Dr. JeanR e g a l
[ E - m a i l :jregal@d.umn.edu].
This award is made possible by
the Health and Environmental
Science Institute (HESI)
Immunotoxicology Young
Investigator Student Award Fundof the SOT Endowment.

November 2009

The Imtox SS Reportfrom the 16th Annual
Meeting of the JapaneseSociety of Immunotoxicology
Asahikawa, Japan
August 27-28, 2009
Submitted by: Drs. Dori Germolec
and Judith Zelikoff
As part of the ongoingcooperation and scientificinterchange that the ImTox SS has
with the Japanese Society of
Immunotoxicology (JSIT), we(Judy and Dori) were chosen to
represent our specialty Section at
the 16th Annual Meeting of the
JSIT. The theme for this year’s
meeting, held in the beautiful cityof Asahikawa on the Island of
Hokkaido, was “Children and
Immunity”.

beautiful gardens that front local
homes and farms. That evening
we joined our hosts for the JSIT
conference opening dinner. Dr.
Takahiko Yoshida, from the
Asahikawa Medical College andPresident and Organizer of the
16th Annual Meeting, and the
Executive Committee welcomed
us. The dinner was an excellent
opportunity for us to havewonderful Japanese cuisine anddiscuss current and futurecollaborations between the JSIT
and the ImTox SS.

We arrived in Tokyo on the 25thof August and were whisked toour hotel near the Haneda airport.
There we were met by one of ourhosts for this journey, Dr.
K a z u i c h i N a k a mu r a , w h o
introduced us to Tokyo and thewonders of Japanese noodle soup.
On the 26th we joined Dr.
Nakamura and a large group of
JSIT members for the flight from
Tokyo to Asahikawa. Hokkaido
is a volcanic island, and on ourjourney to Asahikawa we weretreated to spectacular mountainviews and given a taste of theDr. Yoshida opened the meetingon Thursday morning, and thesessions began with oralpresentations on the effects ofenvironmental chemicals onallergic and infectious disease. In
a session chaired by Dr. Yoshida,
Dori presented the first special
lecture of the meeting entitled“Does immunomodulation early inlife increase disease risk inchildren and beyond?”
Oral
presentations continued in theearly afternoon in a session
chaired by Dr. Yasuhide Kouchi
and focused on novel methods inimmunotoxicity.
The meetingtheme was highlighted in a
symposium entitled, “Children
and Immunity” chaired by Drs.
Fujio Kayama and Dr. Kazuichi
Nakamura.
The symposiumfeatured presentations by Dr. Sho
Ishikawa on the breakdown ofmucosal immunity in the gut andallergic sensitization by dioxins,

11

Immunotoxicology Specialty Section

Dr. Chisato Mori on a healthexamination system to prevent
fetal exposure to persistentorganic pollutants and atopic
dermatitis in infants, and Judy on
how prenatal exposure to cigarettesmoke increases tumor
susceptibility of juvenile mice via
changes in anti-tumor
mechanisms. That evening, the
JSIT hosted a wonderful dinnerreception at the Asahikawa Grand
Hotel. We were fortunate that Dr.
Takemi Otsuki was willing toperform his “Song for the JSIT”

which he debuted at an earlier
JSIT meeting. It was a treat to see
old friends, begin newcollaborations and hear about theexciting sessions being plannedfor both the 49th Annual Meetingof the SOT in Salt Lake City in
March 2010 and the 17th Annual
Meeting of the JSIT in Tsukuba in
September 2010.
The second day featured a special
lecture chaired by Dr. Jun-ichi
Sawada and presented by Dr.
Masao Kosuge, the Director

Emeritus of the Asahikawa
Asahiyama Zoo regarding the roleof the Asahiyama Zoo in
education and species
preservation. We were fortunate to
get an “up close and personal”
view of the zoo and all of its
inhabitants that afternoon. The
afternoon Workshop focused on“Standardization of an
immunotoxicity test: T celldependent antibody response to
keyhole limpet hemocyanin.”
Oral and poster presentations
highlighted the outstanding

Immunotoxicologists at the 16th Annual JSIT Meeting
Back Row: Fujio Kayama, Dori Germolec, Yasuhide Kouchi, Qing Li, Judy Zelikoff
Front Row: Takahiko Yoshida

November 200912

Immunotoxicology Specialty Sectioncontributions of our Japanesecolleagues in all aspects ofimmunotoxicology.
After the meeting, we wereentertained by Dr. Yoshida whobrought us up to the mountains fora visit to Daisetsuzan National
Park and its volcanic hot springs,
followed by a wonderful Japanesemeal with many of our meetingcolleagues. Our flight back toTokyo from Asahikawa was justthe beginning of anotheradventure, in which we traveledthrough the Ginza and up to the
top of the Tokyo Tower. Dr.
Nakamura acted as our tour guidefor a final day in Tokyo, where we
saw the Great Buddha of
Kamakura, the port of Yokohama
and its magnificent Chinatown, as
well as beautiful shrines andtemples. Our discussions on
immunotoxicology and futurecollaborations did not end until we
stepped on the plane headed backto New York.

We would like to sincerely thankall of our hosts in Japan for theirwarmth, welcome and kindness.
We had many fruitful discussions
about the future of our specialty
section and toxicology in general.
The hospitality that was extended
to us was remarkable and madeour trip a never to be forgotten
experience. We look forward tocontinued collaborations with our
JSIT colleagues.

Immunotoxicologists at the 16th Annual JSIT Meeting
Back Row: Hiroyuki Kojima, Fujio Kayama, Jun-ichi Sawada, Judy Zelikoff, Reiko Teshima, Yoshihiko Nakaki,
Front Row: Takahiko Yoshida, Dori Germolec

November 200913

Immunotoxicology Specialty Section

Announcements

November 200914

Immunotoxicology Specialty Section

Immunotoxicology Job Announcements

November 200915

Immunotoxicology Specialty Section

Announcements

November 200916

Immunotoxicology Specialty Section

Announcements

http://www.emea.europa.eu/pdfs/conferenceflyers/EMEA_CRA_Agenda.pdf

November 200917

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications

Compiled by Haley Neff-LaFord.
ANYTIME you have a new fully published article to report, please send it to the coordinator, Haley
Neff-LaFord: hnlaford@seagen.com
Asthma, Allergy, Autoimmunity & Hypersensitivity
Ayehunie S, Snell M, Child M and KIausner M. A plasmacytoid dendritic cell (CD123+/CD11c−) based
assay system to predict contact allergenicity of chemicals. Toxicology 264:1-9, 2009.
Corsini E, Mitjans M, Galbiati V, Lucchi L, Galli CL and Marinovich M. Use of IL-18 production in a humankeratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory
allergens. Toxicol In Vitro 23:789-96, 2009.
De Jong WH, Arts JHE, De Klerk A, Schijf MA, Ezendam J, Kuper CF and Van Loveren H. Contact andrespiratory sensitizers can be identified by cytokine profiles following inhalation exposure. Toxicology
263:103-111, 2009.
Gusareva ES, Bragina EJ, Buinova SN, Chernyak BA, Puzyrev VP, Ogorodova LM and Lipoldová M.
Chromosome 12q24.3 controls sensitization to cat allergen in patients with asthma from Siberia, Russia.
Immunol Lett 125:1-6, 2009.
Ladics GS and Selgrade MK. Identifying food proteins with allergenic potential: evolution of approaches tosafety assessment and research to provide additional tools. Reg Toxicol Pharmacol 54:S2-S6, 2009.
Wang G, Wang J, Ma H and Khan MF. Increased nitration and carbonylation of proteins in MRL+/+ mice
exposed to trichloroethene: potential role of protein oxidation in autoimmunity. Toxicol Appl Pharmacol
237:188-195, 2009.
White JML, White IR, Kimber I, Basketter DA, Buckley DA and McFadden JP. Atopic dermatitis and allergic
reactions to individual fragrance chemicals. Allergy 64:312-316, 2009.
Developmental Immunotoxicology
Doherty-Lyons SP, Grabowski J, Hoffman C and Zelikoff JT. Early life insult from cigarette smoke may be
predictive of chronic diseases later in life. Biomarkers 114:102-106, 2009.
Pilones K, Tatum A and Gavalchin J. Gestational exposure to mercury leads to persistent changes in T-cell
phenotype and function in adult DBF1 mice. J Immunotoxicol 6:161-170, 2009.
Van Der Ven LTM, Van De Kuil T, Leonards PEG, Slob W, Lilienthal H, Litens S, Herlin M, Hakansson H,
Canton RF, Van Den Berg M, Visser TJ, Van Loveren H, Vos JG and Piersma AP. Endocrine effects ofhexabromocyclododecane (HCDB) in a one-generation reproduction study in Wistar rats. Toxicol Lett 185:5162, 2009.

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Effects: Compounds
Choi HJ, Yang H, Park SH and Moon Y. HuR/ELAVL1 RNA binding protein modulates interleukin-8
induction by muco-active ribotoxin deoxynivalenol. Toxicol Appl Pharmacol 240:46-54, 2009.
Dearman RJ, Betts CJ, Beresford L, Bailey L, Caddick HT and Kimber I. Butyl benzyl phthalate: effects on
immune responses to ovalbumin in mice. J Appl Toxicol 29:118-125.
Kim ID and Ha BJ. Paeoniflorin protects RAW 264.7 macrophages from LPS-induced cytotoxicity andgenotoxicity. Toxicol In Vitro 23:1014-1019, 2009.
Moon Y, Yang H and Park SH. Hypo-responsiveness of interleukin-8 production in human embryonicepithelial intestine 407 cells independent of NF-kappaB pathway: new lessons from endotoxin and ribotoxic
deoxynivalenol. Toxicol Appl Pharmacol 231:94-102, 2009.
Osman AM, van Kol S, Peijnenburg A, Blokland M, Pennings JLA, Kleinjans JCS and van Loveren H.
Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO). J
Immunotoxicol 6:174-183, 2009.
Park EJ, Yoon J, Choi K, Yi J and Park K. Induction of chronic inflammation in mice treated with titanium
dioxide nanoparticles by intratracheal instillation. Toxicology 260:37-46, 2009.
Qazi MR, Bogdanska J, Butenhoff JL, Nelson BD, DePierre JW and Abedi-Valugerdi M. High-dose, shortterm exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the numberof circulating neutrophils differently, but enhances the inflammatory responses of macrophages tolipopolysaccharide (LPS) in a similar fashion. Toxicology 262:207-214, 2009.
Qazi MR, Xia Z, Bogdanska J, Chang SC, Ehresman DJ, Butenhoff JL, Nelson BD, DePierre JW and AbediValugerdi M. The atrophy and changes in the cellular compositions of the thymus and spleen observed inmice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in partby peroxisome proliferator-activated receptor-alpha (PPARa). Toxicology 260:68-76, 2009.
Schellenberger MT, Grova N, Willième S, Farinelle S, Prodhomme EJF and Muller CP. Modulation of Benzo[a]pyrene induced immunotoxicity in mice actively immunized with a B[a]P-diphtheria toxoid conjugate.
TAAP 240:37-45, 2009.
Tangjarukij C, Navasumrit P, Judith T. Zelikoff JT and Ruchirawat M. The effects of pyridoxine deficiency
and supplementation on hematological profiles, lymphocyte function, and hepatic cytochrome P450 in
B6C3F1 mice. J Immunotoxicol 6:147-160, 2009.
Tomiyama K, Yamaguchi A, Kuriyama T and Arakawa Y. Analysis of mechanisms of cell death of Tlymphocytes induced by organotin agents. J Immunotoxicol 6:184-193, 2009.
Uto T, Akagi T, Hamasaki T, Akashi M and Baba M. Modulation of innate and adaptive immunity bybiodegradable nanoparticles. Immunol Lett 125:46-52, 2009.

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Verhagen H, Boekhorst J, Kamps L, Van Lieshout MJ, Ploeger H, Verreth D, Salminen S and Van Loveren H.
Novel foods: an exploratory study into their grey area. Br J Nutr 28:1-8, 2009.
Waché YJ, Hbabi-Haddioui L, Guzylack-Piriou L, Belkhelfa H, Roques C and Oswald IP. The mycotoxin
Deoxynivalenol inhibits the cell surface expression of activation markers in human macrophages. Toxicology
262:239-244, 2009.
Yang H, Choi HJ, Park SH, Kim JS and Moon Y. Macrophage inhibitory cytokine-1 (MIC-1) and subsequent
urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 coloncancer cells. Biochem Pharmacol 78:1205-13, 2009.
General Immunotoxicology
Dearman RJ, Cumberbatch M, Maxwell G, Basketter DA and Kimber I. Toll-like receptor ligand activation ofmurine bone marrow-derived dendritic cells. Immunology 126:475-484, 2009.
Funatake CJ, Ao K, Suzuki T, Murai H, Yamamoto M, Fujii-Kuriyama Y, Kerkvliet NI and Nohara K.
Expression of constitutively-active aryl hydrocarbon receptor in T-cells enhances the down-regulation of
CD62L, but does not alter expression of CD25 or suppress the allogeneic CTL response. J Immunotoxicol
6:194-203, 2009.
Kerkvliet NI, Steppan LB, Vorachek W, Oda S, Farrer D, Wong CP, Pham D and Mourich DV. Activation ofaryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin prevents the development of diabetes in
NOD mice and increases the frequency of CD4+CD25+Foxp3+ cells . Immunotherapy 1:539-547, 2009.
Quinn MJ, Jr., McFarland CA, LaFiandra EM and Johnson MS. A preliminary assessment of relative
sensitivities to foreign red blood cell challenges in the northern bobwhite for potential evaluation of
immunotoxicity. J Immunotoxicol 6:171-173, 2009.
Yang H, Park SH, Choi HJ and Moon Y. Epithelial cell survival by activating transcription factor 3 (ATF3) inresponse to chemical ribosome-inactivating stress. Biochem Pharmacol 77:1105-15, 2009.
Methods
Casati S, Aeby P, Kimber I, Maxwell G, Ovigne JM, Roggen E, Rovida C, Tosti L and Basketter D. Selectionof chemicals for the development and evaluation of in vitro methods for skin sensitization testing. Altern Lab
Anim 37:305-312, 2009.
Dearman RJ and Kimber I. Animal models of protein allergenicity: potential benefits, pitfalls and challenges.
Clin Exp Allergy 39:458-468, 2009.
Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P and Van Den Heuvel R.
Gene profiles of THP-1 macrophages after in vitro exposure to respiratory (non-)sensitizing chemicals:
Identification of discriminating genetic markers and pathway analysis. Toxicol In Vitro 23:1151-1162, 2009.

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Reviews, Book Chapters, Commentaries
Basketter DA, McFadden JP, Gerberick GF, Cockshott A and Kimber I. Nothing is perfect, not even the local
lymph node assay: a commentary and implications for REACH. Contact Derm 60:65-69, 2009.
Cressman R and Ladics GS. Further evaluation of the utility of "sliding window" FASTA in predicting crossreactivity with allergenic proteins. Reg. Toxicol Pharmacol 54:S20-S25, 2009.
Dearman RJ, Betts CJ, Caddick HT and Kimber I. Cytokine profiling of chemical allergens in mice: impact of
mitogen on selectivity of response. J Appl Toxicol 29:233-241, 2009.
Kimber I, Cumberbatch M and Dearman RJ. Langerhans cell migration: not necessarily always at the centerof the skin sensitization universe. J Invest Derm 129:1852-1853, 2009.
Ladics GS. Food processing and allergenicity. Mol Nutr Food Res 53:945, 2009.
McFadden JP, White JML, Basketter DA and Kimber I. Does hapten exposure predispose to atopic disease?
The hapten-atopy hypothesis. Trends in Immunol 30:67-74, 2009.
Mishra KP. Lead exposure and its impact on immune system: A review. Toxicol In Vitro 23:969-972, 2009.
Ng SP, Yoshido K and Zelikoff JT. Host resistance tumor challenge assays. In: Techniques in
Immunotoxicology (R. Dietert, Ed.) Informa Press. 2009.
Park MV, Lankveld DP, van Loveren H and de Jong WH. The status of in vitro toxicity studies in the risk
assessment of nanomaterials. Nanomed 4:669-685, 2009.
Selgrade MK, Bowman CC, Ladics GS, Privalle L and Laessig SA. Safety assessment of biotechnology
products for potential risk of food allergy: implications of new research. Toxicol Sci 110:31-39, 2009.
Singh KP, Casado FL, Opanashuk LA and Gasiewicz TA. The aryl hydrocarbon receptor has a normal
function in the regulation of hematopoetic and other stem/progenitor cell populations. Biochem Pharmacol
77:577-587, 2009.
Thomas K, MacIntosh S, Bannon G, Herouet-Guicheney C, Holsapple M, Ladics G, McClain S, Vieths S,
Woolhiser M and Privalle L. Scientific advancement of novel protein allergenicity evaluation: an overview ofwork from the HESI Protein Allergenicity Technical Committee (2000-2008). Food Chem Toxicol 47:10411050, 2009.
Zelikoff JT. Other environmental health issues: Inhaled woodsmoke. In: Encyclopedia of Environmental
Health. J. Nriagu (Ed.). Elsevier, UK. 2009.

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