The 58th Japanese Peptide Symposium
October 20 (Wednesday)
9:00–9:10

Opening Remarks (Yoshio Hayashi)

9:10–10:27

Young Investigator’s Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 1 (chairs: Hiroshi Inaba, Kohei Sato)

Y-01

Development of copper and iron-mediated Cys-Trp-linking reaction
Daishiro Kobayashi, Yutaka Kohmura, Junya Hayashi, Masaya Denda, Akira Otaka (Institute ofBiomedical Sciences and Graduate School of Pharmaceutical Sciences, Tokushima University)

Y-02

Fragment coupling reaction of protected peptides using ψ-Wang handle and its vinyl handles
Ayaka Okawara1, Mariko Kikuchi1, Reiko Kurotani1, Kenta Teruya2, Hiroyuki Konno1 (1Graduate
School of Science and Engineering, Yamagata University, 2Graduate School of Medicine, TohokuUniversity)

Y-03

One-pot peptide ligation mediated by N-terminal thiazolidine ring-opening using an 2aminobenzamide-type formaldehyde scavenger
Koki Nakatsu1, Hiroshi Murakami1,2, Gosuke Hayashi1, Akimitsu Okamoto3,4 (1Graduate School ofEngineering, Nagoya University, 2Institutes of Innovation for Future Society, Nagoya University,
3

Graduate School of Engineering, The University of Tokyo, 4Research Center for Advanced Scienceand Technology, The University of Tokyo)
Y-04

Synthetic study for cyclodepsipeptide teixobactin
Hongbin Zhao1, Takuya Tokunaga1, Yuichi Masuda2, Kosuke Ohsawa1, Takayuki Doi1 (1Graduate
School of Pharmaceutical Sciences, Tohoku University, 2Graduate School of Bioresources, MieUniversity)

Y-05

Discovery and characterization of a novel peptide prenyltransferase for facile preparation ofprenylated macrocyclic peptides
Yuchen Zhang1, Keisuke Hamada2, Dinh Thanh Nguyen1, Sumika Inoue1, Masayuki Satake1,Masahiro Okada3, Toru Sengoku2, Yuki Goto1, Hiroaki Suga1 (1Department of Chemistry, Graduate
School of Science, The University of Tokyo, 2Department of Biochemistry, Graduate School ofMedicine, Yokohama City University, 3Department of Material and Life Chemistry, KanagawaUniversity)

Y-06

Direct screening of a target-specific covalent binder: stringent regulation of warhead reactivity ina matchmaking environment
Yudai Tabuchi1, Takahito Watanabe1, Riku Katsuki1, Yuji Ito2, Masumi Taki1 (1Graduate School ofInformatics and Engineering, The University of Electro-Communications (UEC), 2Graduate Schoolof Science and Engineering, Kagoshima University)

Y-07

Neutralization of irreversible-inhibition effect of boronic-acid-modified covalent drug by diolantidote

Takashi Abe, Yudai Tabuchi, Masumi Taki (The Graduate School of Informatics and Engineering, The
University of Electro-Communications)
10:27–10:45

Break

10:45–12:02

Young Investigator’s Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 2 (chairs: Yuki Goto, Kazuya Kobayashi)

Y-08

Control of peptide self-assembly and function with DNA-templated co-assembly
Christella K. Gordon, Allisandra Rha, Regina Luu, Alexis Roberson, George Poppitz, David G. Lynn
(Department of Chemistry and Biology, Emory University)

Y-09

Efficient inhibition of myostatin activity by functionalized peptides with photooxygenation catalyst
Hideyuki Okamoto1, Atsuhiko Taniguchi1, Shoya Usami1, Masahiro Katsuyama1, Sho Konno1,Akihiro Taguchi1, Kentaro Takayama1,2, Yoshio Hayashi1 (1Department of Medicinal Chemistry,
Tokyo University of Pharmacy and Life Sciences, 2Department of Environmental Biochemistry, Kyoto
Pharmaceutical University)

Y-10

Development of an ultrapotent and selective human β-factor XIIa inhibitor in a cyclotide scaffold
Wenyu Liu1, Simon de Veer2, Yen-Hua Huang2, Toru Sengoku3, Chikako Okada3, Kazuhiro Ogata3,Christina Zdenek4, Bryan Fry4, Joakim Swedberg2, Toby Passioura1, David Craik2, Hiroaki Suga1(1Department of Chemistry, Graduate School of Science, the University of Tokyo, 2Institute for
Molecular Bioscience, The University of Queensland, 3Department of Biochemistry, Graduate Schoolof Medicine, Yokohama City University, 4Venom Evolution Lab, School of Biological Sciences, The
University of Queensland)

Y-11

Identification of a novel anti-cancer peptide that derives from subtilisin
Sibo Wei, Li Li, Michio Suzuki, Peng Lu, Suguru Okuda, Ken Okamoto, Hideaki Itoh, Koji Nagata(Department of Applied Biological Chemistry, Graduate School of Agriculture and Life Science, The
University of Tokyo)

Y-12

PRMT5 methylates tumor suppressor protein p53 to regulate the stability of tetramer
Natsumi Nakagawa1, Shuya Sakaguchi2, Junya Wada2, Rui Kamada2, Kazuyasu Sakaguchi2(1Department of Chemistry, Kurume University School of Medicine, 2Laboratory of BiologicalChemistry, Department of Chemistry, Faculty of Science, Hokkaido University)

Y-13

Development of helical peptides containing non-proteinogenic amino acids inhibiting VDRtranscription
Mami Takyo1,2, Takashi Misawa2, Takashi Kurohara2, Hiroaki Ishida3, Keiko Yamamoto3, Yosuke
Demizu1,2 (1Graduate School of Medical Life Science, Yokohama City University, 2National Instituteof Health Sciences, 3Laboratory of Drug Design and Medical Chemistry, Showa PharmaceuticalUniversity)

Y-14

Novel peptides enhancing ghrelin sensitivity
Ken Shimizu, Kentaro Kaneko, Daiki Koyama, Kazuo Inoue, Kousaku Ohinata (Division of Food
Science and Biotechnology, Graduate School of Agriculture, Kyoto University)12:02–12:15

Break

12:15–13:15

Lunch Break & Online Business Seminar

13:15–13:25

Break

13:25–14:31Young Investigator’s Oral Presentations (8 min talk, 3 min discussion & exchange)
Session 3 (chairs: Kentaro Takayama, Yuya Asahina)

Y-15

Development of antimicrobial peptide-antibiotic conjugates for improved antimicrobial activity
Ruka Yamauchi, Kenichi Kawano, Daigo Kajiwara, Yousuke Yamaoka, Yoshiaki Yano, Kiyosei
Takasu, Katsumi Matsuzaki (Graduate School of Pharmaceutical Sciences, Kyoto University)

Y-16

Saporin toxin-derived cell-penetrating peptide for intracellular delivery of biofunctional molecules
Momoko Obuki1, Miku Katayama1, Kosuke Noguchi1, Stefania Zuppone2, Mayu Yamana3, Tomoka
Takatani-Nakase4,5, Masashi Ueda3,6, Riccardo Vago2,7, Shiroh Futaki8, Arwyn T. Jones9, IkuhikoNakase1 (1Graduate School of Science, Osaka Prefecture University, 2IRCCS San Raffaele Hospital,
3

College of Pharmacy, Okayama University, 4College of Pharmacy, Mukogawa Women’s University,

5Institute for Biosciences, Mukogawa Women’s University, 6Graduate School of Medicine, Dentistry,and Pharmaceutical Sciences, Okayama University, 7University Vita-Salute San Raffaele, 8Institutefor Chemical Research, Kyoto University, 9School of Pharmacy and Pharmaceutical Sciences, CardiffUniversity)
Y-17

Intracellular delivery of antibodies by liquid-liquid phase separation
Takahiro Iwata, Hisaaki Hirose, Kentarou Sakamoto, Yusuke Hirai, Jan Vincent V. Arafiles, Misao
Akishiba, Miki Imanishi, Shiroh Futaki (Institute for Chemical Research, Kyoto University)

Y-18

Construction of enveloped viral replica embedded with membrane proteins
Hiroto Furukawa1, Keigo Nakamura2, Hiroshi Inaba1, Shin-ichi Sawada2, Yoshihiro Sasaki2, Kazunari
Akiyoshi2, Kazunori Matsuura1 (1Graduate School of Engineering, Tottori University, 2Graduate
School of Engineering, Kyoto University)

Y-19

Enzymatic basis of guanidine bis-prenylation in argicyclamides biosynthesis
Kenichi Matsuda1, Chin-Soon Phan2, Nandani Balloo2, Kei Fujita1, Tatsufumi Okino2, Toshiyuki
Wakimoto1 (1Faculty of Pharmaceutical Sciences, Hokkaido University, 2Faculty of Environmental
Earth Science, Hokkaido University)

Y-20

Biosynthesis of a carnosine-like peptide in mouse skeletal muscles by dietary g-aminobutyric acid
Takumi Komaru, Noriyuki Yanaka, Thanutchaporn Kumrungsee (Graduate School of Integrated
Sciences for Life, Hiroshima University)

14:31–14:50

Break

14:50–15:50Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 1 (chairs: Takayuki Doi, Taku Yoshiya)

O-01
Novel coupling reagent for peptide syntheses with vinyl ester as the key intermediateJunfeng Zhao (School of Pharmaceutical Sciences, Guangzhou Medical University, College ofChemistry and Chemical Engineering, Jiangxi Normal University)
O-02

Late-stage installation of dehydroamino acid motif into peptides through N-chlorination of amides
Takeshi Nanjo, Takuma Oshita, Ayaka Matsumoto, Yoshiji Takemoto (Graduate School ofPharmaceutical Sciences, Kyoto University)

O-03

Late-stage solubilization strategy to overcome solubility challenges using peptide hydrazide
Kohei Sato1,2, Shoko Tanaka2, Shugo Tsuda3, Tetsuo Narumi1,2,4, Taku Yoshiya3, Nobuyuki Mase1,2,4(1Graduate School of Integrated Science and Technology, Shizuoka University, 2Graduate School of
Science and Technology, Shizuoka University, 3Peptide Institute, Inc., 4Research Institute of Green
Science and Technology, Shizuoka University)

15:50–16:05

Break

16:05–16:55

Invited Lectures (20 min talk, 5 min discussion & exchange)(chair: Atsuhiko Taniguchi)

K-1

Exploring omega-ester-containing macrocyclic peptides of ribosomal origin
Seokhee Kim (Seoul National University)(chair: Hiroshi Tsutsumi)

K-2

Chemical tools for histidine and arginine phosphorylation
Jung-Min Kee (Ulsan National Institute of Science and Technology (UNIST))

16:55–17:10

Break

17:10–18:00

Invited Lectures (20 min talk, 5 min discussion & exchange)(chair: Takaki Koide)

I-1

Studies on protein ubiquitination using chemically synthesized protein tools
Lei Liu (Department of Chemistry, Tsinghua University)(chair: Hirokazu Tamamura)I-2

New methods for construction of complex peptide macrocycles
Gong Chen (Nankai University)

18:00–18:15Break

18:15–19:15

Poster Presentations (60 min)Session 1 (P-001–P-042)

October 21 (Thursday)
9:00–9:50
Invited Lectures (20 min talk, 5 min discussion & exchange)(chair: Shiroh Futaki)
I-3

A Sos proteomimetic as a Pan-Ras inhibitor
Seong Ho Hong, Daniel Y. Yoo, Paramjit S. Arora (New York University)(chair: Yoshio Hayashi)

I-4

Directing biosynthesis in type II NRPS pathways
Michael D. Burkart (University of California, San Diego)

9:50–10:05

Break

10:05–11:05

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 2 (chairs: Shinya Oishi, Koushi Hidaka)

O-4

3CL Protease inhibitor with an arylketone warhead group as anti-SARS-CoV-2 agents
Sho Konno1, Kiyotaka Kobayashi1, Miki Senda2, Yuta Funai3, Yuki Seki3, Ikumi Tamai3, LauraSchakel4, Kyousuke Sakata1, Thanigaimalai Pillaiyar5, Akihiro Taguchi1, Atsuhiko Taniguchi1,
Michael Gutschow4, Christa Muller4, Koh Takeuchi6, Mikako Hirohama7, Atsushi Kawaguchi7,Masaki Kojima1, Toshiya Senda2, Yoshiyuki Shirasaka3, Wataru Kamitani8, Yoshio Hayashi1 (1TokyoUniversity of Pharmacy and Life Sciences, 2Structural Biology Research Center, Institute of Materials
Structure Science, High Energy Accelerator Research Organization, 3Faculty of Pharmacy, Instituteof Medical, Pharmaceutical and Health Sciences, Kanazawa University, 4Pharmaceutical Institute,
Pharmaceutical & Medicinal Chemistry, University of Bonn,

5

Pharmaceutical/Medicinal

6Chemistry,

UniversityofTübingen,Pharmaceutical Institute,

CellularandMolecular

Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology,
7

Faculty of Medicine, Transborder Medical Research Center, University of Tsukuba, 8Department ofInfectious Diseases and Host Defense, Graduate School of Medicine, Gunma University)
O-5

Dimerized small molecule HIV-1 fusion inhibitors with dramatic enhancement of their anti-HIV-1
activities
Kohei Tsuji1, Takuya Kobayakawa1, Kento Ebihara1, Takuma Kawada1, Masayuki Fujino2, Yuzuna
Honda1, Nami Ohashi1, Tsutomu Murakami2, Hirokazu Tamamura1 (1Institute of Biomaterials andBioengineering, Tokyo Medical and Dental University (TMDU), 2AIDS Research Center, National
Institute of Infectious Diseases)

O-6

Anti-antibiotic activity of r-Pep2 derived from putative ORF sequence in E.coli rRNA
Yuma Omata, Junya Imaizumi, Rui Kamada, Kazuyasu Sakaguchi (Laboratory of BiologicalChemistry, Department of Chemistry, Faculty of Science, Hokkaido University)

11:05–11:20

Break

11:20–12:20

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 3 (chairs: Hironobu Hojo, Tetsuo Narumi)

O-7

Metal-catalyzed selective cell tagging of a cytotoxic peptide for cancer therapy
Kyohei Muguruma1, Peni Ahmadi2, Tsung-Che Chang2, Katsunori Tanaka1,2,3 (1Department ofChemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute oftechnology,
3O-82

Biofunctional Synthetic Chemistry, RIKEN Cluster for pioneering research,

Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal Universit)

Chemical catalyst-promoted photooxygenation of amyloid peptide in vivo
Youhei Sohma1, Nozomu Nagashima2, Shuta Ozawa3, Masahiro Furuta2, Miku Oi2, Yukiko Hori3,
Taisuke Tomita3, Motomu Kanai2 (1School of Pharmaceutical Sciences, Wakayama MedicalUniversity, 2Synthetic Organic Chemistry Lab., Graduate School of Pharmaceutical Sciences, The
University of Tokyo, 3Neuropathology and Neuroscience Lab., Graduate School of PharmaceuticalSciences, The University of Tokyo)

O-9

Biofunctional peptide-modified exosomes with encapsulation of boron compounds for boron
neutron capture therapy (BNCT)
Shiori Hirase1, Ayako Aoki1, Kenta Morimoto1, Kosuke Noguchi1, Tomoka Takatani-Nakase2,3,Shiroh Futaki4, Yoshihide Hattori5, Mitsunori Kirihata5, Ikuhiko Nakase1 (1Department of BiologicalScience, Graduate School of Science, Osaka Prefecture University, 2College of Pharmacy, Mukogawa
Women’s University, 3Institute for Biosciences, Mukogawa Women’s University, 4Institute for
Chemical Research, Kyoto University, 5Research Center for Boron Neutron Capture Therapy, OsakaPrefecture University)

12:20–12:30

Break12:30–13:30Lunch Break & Online Business Seminar

13:30–13:40

Break

13:40–14:40

The Japanese Peptide Society General Meeting

14:40–14:50

Break

14:50–15:50

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 4 (chairs: Akira Shigenaga, Youhei Sohma)

O-10

Design of curvature-sensing peptides for highly sensitive detection of bacterial extracellular vesicles
Kenichi Kawano1,2, Fumiaki Yokoyama1,3, Kouhei Kamasaka1, Jun Kawamoto1, Takuya Ogawa1,
Tatsuo Kurihara1, Shiroh Futaki1 (1Institute for Chemical Research, Kyoto University, 2Graduate
School of Pharmaceutical Sciences, Kyoto University, 3Department of Biosystems Science andEngineering, ETH Zurich)

O-11

Intracellular reconstitution and analysis of protein complexes by Yn self-assembling peptide tags
Takayuki Miki, Masahiro Hashimoto, Taichi Nakai, Keigo Kajiwara, Hisakazu Mihara (School of Life
Science and Technology, Tokyo Institute of Technology)

O-12

Advances in CCAP method for development of functionalized antibody conjugate
Yuji Ito1, Abdur Rafique1, Shun Masuda2, Yukie Nohara2, Shugo Tsuda2, Taku Yoshiya2 (1GraduateSchool of Science and Engineering, Kagoshima University, 2Peptide Institute, Inc.)
15:50–16:05

Break16:05–17:05

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 5 (chairs: Yuji Ito, Wataru Nomura)O-13

Peptide-based ionic liquids as an innovative approach to tackle skin and soft tissue infections:antibacterial, antibiofilm and collagenesis-boosting effects
Ana Gomes1 Lucinda Bessa1, Iva Fernandes1, Ricardo Ferraz1,2, Cláudia Monteiro3, Cristina Martins3,
Nuno Mateus1, Paula Gameiro1, Cátia Teixeira1, Paula Gomes1 (1LAQV- REQUIMTE, Departamentode Qumica e Bioquimica, Faculdade de Ciencias, Universidade do Porto, 2Ciências Químicas e das
Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, 3INEB-i3S, Instituto de Engenharia
Biomédica, Instituto de Investigação e Inovação em Saúde, Universidade do Porto)

O-14

3D culture of cancer cells in functionalized peptide hydrogels for construction of tumor tissue
models and anticancer drug tests
Hiroshi Tsutsumi, Jyh Yea Chia, Takayuki Miki, Hisakazu Mihara (School of Life Science andTechnology, Tokyo Institute of Technology)

O-15

High-throughput identification of bibalent peptides by cDNA display and combinatorial
approaches
Taro Noguchi, Kanako Nakao, Shigefumi Kumachi, Masayuki Tsuchiya, Naoto Nemoto (Epsilon
Molecular Engineering, Inc.)

17:05–17:20

Break

17:20–18:20

Poster Presentations (60 min)Session 2 (P-043–P-084)

18:20–18:30

Break

18:30–21:00

Online Social Gathering

October 22 (Friday)
9:00–9:50

Ceremony and Lecture of the Akabori Memorial Award 2020
(chair: Kenichi Akaji)

Chemoselectivity in peptide synthesis
Philip E. Dawson (The Scripps Research Institute)9:50–10:05

Break

10:05–11:05

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 6 (chairs: Akira Otaka, Hiroyuki Konno)

O-16

PEG stapling for enhanced conformational stability within β-sheet proteins and α-helical coiled
coils
Joshua L. Price (Department of Chemistry and Biochemistry, Brigham Young University, USA)

O-17

Establishment of HP1 semi-synthesis and structural dynamics of its N-tail detected with ESR
Isao Suetake1,2,3, Toshiaki Arata1,4, Toru Kawakami1, Risa Mutoh5, Yuichi Mishima1, Kazunobu Sato6,Takeji Takui6, Toshiki Takei1, Toshimichi Fujiwara1, Makoto Miyata4, Hironobu Hojo1 (1Institute forProtein Research, Osaka University, 2Center for Twin Research, Graduate School of Medicine, Osaka
University, 3Department of Nutritional Sciences, Nakamura Gakuen University, 4Department ofBiology, Graduate School of Science, Osaka City University, 5Department of Applied Physics,Fukuoka University, 6Department of Chemistry and Molecular Materials Sciences, Graduate Schoolof Science, Osaka City University)

O-18

Chemical synthesis of Torenia plant pollen tube attractant proteins by KAHA ligation
Nandarapu Kumarswamyreddy1, Damodara N. Reddy1, Nao Kamiya2, Ryoko Tsukamoto2, Masahiro
M. Kanaoka2, Tetsuya Higashiyama1,2,3, Shunsuke Oishi1, Jeffrey W. Bode1,4 (1Institute ofTransformative Bio-Molecules (WPI-ITbM), Nagoya University, 2Division of Biological Science,Graduate School of Science, Nagoya University, 3Department of Biological Sciences, Graduate Schoolof Science, University of Tokyo, 4Laboratorium for Organische Chemie, Department of Chemistry
and Applied Biosciences, ETH Zurich)

11:05–11:20

Break

11:20–12:20

Poster Presentations (60 min)Session 3 (P-085–P-125)

12:20–12:30

Break

12:30–13:30

Lunch Break & Online Business Seminar

13:30–13:40

Break

13:40–15:00

Oral Presentations (15 min talk, 5 min discussion & exchange)
Session 7 (chairs: Kazunori Matsuura, Ikuhiko Nakase)

O-19

Stabilization of microtubules by photoaffinity labeling of a Tau-derived peptide
Hiroshi Inaba1, Soei Watari1, Arif Md. Rashedul Kabir2, Akira Kakugo2, Kazuki Sada2, Kazunori
Matsuura1 (1Graduate School of Engineering, Tottori University, 2Graduate School of Science,
Hokkaido University)



O-20

Cell adhesion activity of octaarginine
Yuji Yamada, Toru Onda, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu (School ofPharmacy, Tokyo University of Pharmacy and Life Sciences)O-21

A method for obtaining protein-binding peptides from a random triple-helical peptide library
Ryo Masuda1, Khine Phyu Phyu Thant2, Tetsuya Kadonosono3, Takaki Koide1,2 (1Waseda ResearchInstitute for Science and Engineering, Waseda University,2Department of Chemistry andBiochemistry, School of Advanced Science and Engineering, Waseda University, 3Department of Life
Science and Technology, School of Life Science and Technology, Tokyo Institute of Technology)
O-22

Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics
Kenichiro Ito, Yoshihiko Matsuda, Ayako Mine, Natsuki Shikida, Kazutoshi Takahashi, Kyohei
Miyairi, Kazutaka Shimbo, Yoshimi Kikuchi, Atsushi Konishi (Research Institute for Bioscience
Product & Fine Chemicals, Ajinomoto Co., Inc.)

15:00–15:15

Break

15:15–16:05

Lectures of the Young Investigator Award(chair: Yosuke Demizu)

Fundamental studies on the development of next-generation medium-sized peptide drugs
Takashi Misawa (National Institute of Health Sciences)(chair: Hiroaki Suga)
Conformational studies of alanyl-backbone peptoids and application to biomolecular recognition
Jumpei Morimoto (Graduate School of Engineering, The University of Tokyo)
16:05–16:20

Break

16:20–17:00

Lecture of the Japanese Peptide Society Award(chair: Kazuyasu Sakaguchi)

Construction of functional peptides based on de novo design approaches
Hisakazu Mihara (Tokyo Institute of Technology)
17:00–17:10

Closing Remarks (Yoshio Hayashi)