The 19th Annual Meeting of JSIT
Special Lecture 1
Overview and Applicationof the WHO/IPCS
Harmonized Guidance for
Immunotoxicity: Risk
Assessment for Chemicals

Henk van Loveren

Maastricht University,
National Institute of Public
Health and theEnvironment, The
Netherlands

Special Lecture 2
New with old in
immunotoxicologicalresearch ---- What has
been and what shall be in
our Society ofImmunotoxicology

Motoyasu Ohsawa

Hatano ResearchInstitute, Food and Drug
Safety Center, Hadano,
Japan.

Master’s Lecture１
Molecular mechanism offatigue and relationshipbetween immunotoxicology
and fatigue

Kazuhiro Kondo

Department of Virology,
The Jikei University
School of Medicine

Master’s Lecture 2

Pathological linkage of
metabolic disease andautoimmunity by Apoptosis Toru Miyazaki
Inhibitor of Macrophage(AIM)

Laboratory of Mlecular
Biomedicine for
Pathogenesis, Center for
Disease Biology andIntegrative Medicine,
Faculty of Medicine, The
University of Tokyo,
Tokyo, Japan

Awards Lectures <JSIT RESARCH AWARD >Study on the aggravation
mechanism of allergy
induced by environmental
chemicals

Eiko Koike

Center for Environmental
Health Sciences, National
Institute forEnvironmental Studies,
Tsukuba, Japan

Awards Lectures <JSIT RESARCH AWARD > (Sympojium)
Immunological analysis ofasbestos-exposed people
for identification of new
diagnostic markers〇Yasumitsu Nishimura (1),Naoko Kumagai-Takei (1),Hidenori Matsuzaki(1), Suni
Lee (1) , Megumi Maeda (2), Takumi Kishimoto(3) ,Takemi Otsuki(1)(1)Department ofHygiene, Kawasaki
Medical School, Kurashiki,Japan , (2)Laboratory of
FunctionalGlycobiochemistry,
Department of
Biofunctional Chemistry,
Graduate School ofEnvironmental and Life
Science, Okayama
University, Okayama,Japan , (3)Okayama Rosai
Hospital, Okayama, Japan
Symposium“Progress in research for immunotoxicology”Topics of research on sickhouse syndrome, withspecial reference to an

Department of human
Kou Sakabe

structure and function,
Tokai University School of

immunotoxicological

Medicine, Kanagawa,aspect

Japan
Department of Tropical

Advances in gut immunity
to gastrointestinal

Kenji Ishiwata

nematode infections
WorkshopMedicine, The Jikei
University School ofMedicine, Tokyo, Japan"In vitro immunotoxicology"
Laboratory of Toxicology,

Current Trend on In Vitro
Immunotoxicology in EU

Emanuela Corsini

Dipartimento di Scienze
Farmacologiche e
Biomolecolari, Faculty ofPharmacy, Università degliStudi di Milano, Milan,Italy

Development andapplication of an in vitro
skin sensitization test
Hitoshi Sakaguchi
named h-CLAT based onalteration of dendritic cellsurface markers expression

Safety Science Reserach
Laboratories, KaoCorporation, Tochigi,
Japan

Study on safetyassessment forsensitization using
alternative methods

Taro Ashikaga

Research Center, ShiseidoCo., Ltd., Kanagawa,Japan

Setsuya Aiba

Department ofDermatology, Tohoku
University Graduate
School of Medicine,
Sendai, Japan

Development of assay
system for immunotoxicity
using cytokine reporter
cells (Multi-ImmunoToxassay)

Irradiation of light emitting
Kyung Ah Cheong, Changdiode at 850 nm inhibits T
hyun Kim, Yun-Seok Choi, 〇cell-induced cytokine
Ai-Young Lee
expression

Department ofDermatology, Dongguk
University Ilsan Hospital,South Korea

Oral Presentations

Effects of intratracheal
exposure to phthalates inan allergic asthma〇Rie Yanagisawa(1), EikoKoike(1), Tin Tin WinShwe(1), Takamichi
Ichinose(2), Hiroshi
Takano(3)(1)Center for
Environmental HealthSciences, National
Institute forEnvironmental Studies,Japan , (2)Department of
Health Sciences, Oita
University of Nursing andHealth Sciences,
Notsuharu, Oita, Japan ,(3)Graduate School ofEngineering, Kyoto
University, Kyoto, Japan

(1)Center for
Environmental HealthSciences, National
Expression ofInstitute for〇Tin Tin Win Shwe(1), Rie

neuroimmune biomarkers
Yanagisawa(1), eikoin hypothalamus of allergic
Koike(1), Hiroshi Nitta(1),mice after early phthalate
Hirohisa Takano(2)exposure

Environmental Studies,
Tsukuba, Japan ,(2)Department ofEnvironmental
Engineering, Graduate
School of Engineering,
Kyoto University, Kyoto,Japan(1)Div. Novel Foods

Rika Nakamura(1),○Ryosuke Nakamura(1),Analysis of serum IgE fromShinobu Sakai(1), Reiko
patients sensitized to acidAdachi(1), Yasuharu
hydrolyzed wheat protein
Itagaki(2), Yuma
in facial soap
Fukutomi(3), ReikoTeshima(1)Size-dependent effect ofamorphous silica
nanoparticles on atopic
dermatitis

Immunochem., Natl. Inst.
Health Sci., Tokyo, Japan ,(2)Dept. Health Nutr.,
Hokkaido Bunkyo Univ.,
Hokkaido, Japan , (3)Clin.
Res. Ctr. Allergy
Rheumatol., Sagamihara
Natl. Hosp., Kanagawa,Japan(1)Laboratory ofToxicology and Safety
Science, Graduate Schoolof PharmaceuticalSciences, Osaka〇Yasuo Yoshioka(1), Toshiro University, Osaka, Japan ,Hirai(1), Shin-ichi(2)Laboratory ofTsunoda(2),(3), Hiromi
BiopharmaceuticalNabeshi(4), Tomoaki
Research, NationalYoshikawa , Yasuo
Institute of BiomedicalTsutsumi(1),(2),(3)Innovation, Osaka, Japan, (3)MEI center, Osaka
University, Osaka, Japan ,(4)National Institute of
Health Science, Tokyo,Japan(1)CERI Hita, Chemicals
Evaluation and Research〇Toshio Kobayashi(1),Applicability of CBA/J miceto the Local Lymph Node
Assay: BrdU-ELISA.

Junichi Kikuchi(1),YasuhiroTsubokura(1),Masanori Taruki(2), SyozoAjimi(1), Masahiro Takeyoshi(3)Institute, Japan , (2)CERI
Kurume , Chemicals
Evaluation and ResearchInstitute, Japan. ,(3)Chemicals Assessment
and Research Center,
Chemicals Evaluation andResearch Institute,Japan.

Sensitization study byqualitative structure-Department of〇Kazuhiro Sato, Yukinori

toxicity relationships(QSTR) approaches

KusakaEffects of AhR agonists on
IL-17 and IL-22 gene

〇Hiroyuki Kojima(1), Ryuta
Muromoto(2), Miki

Environmental Health,
School of Medicine,
University of Fukui, Fukui,Japan(1)Hokkaido Institute of
Public Health, Sapporo,expressions in mouse TTakahashi(2), Shinji

Japan , (2)Graduate

lymphoma EL4 cells

Takeuchi(1), Tadashi
Matsuda(2)School of PharmaceuticalSciences, Hokkaido
University, Sapporo,Japan

Effects of inorganic
arsenite on the signal
pathway evoked by ATPexposure

Faculty of Pharmaceutical〇Daigo Sumi, Hideta Okada,Sciences, Tokushima
Kuniko Yogi, Hideki
Bunri University,Miyataka, Seiichiro Himeno
Tokushima, Japan(1)Department ofContinuous exposure of〇Suni Lee(1), Hidenori
Matsuzaki(1) , Megumi

Hygiene, Kawasaki
Medical School, Kurashiki,Japan , (2)Lab. Functional

asbestos accelerates cell
cycle progression in MT-2

Maeda(2), Naoko KumagaiTakei(1), YasumitsuGlycobiochemistry, Dept.
Biofunctional Chemistry,

Cell

Nishimura(1), Takemi
Otsuki(1)Graduate School ofEnvironmental and LifeScience, Okayama Univ.,
Okayama, Japan〇Hidenori Matsuzaki(1),Molecular mechanisms ofalteration of MT-2 cells
induced by long term

Suni Lee(1), Megumi
Maeda(2) , Naoko KumagaiTakei(1), Yasumitsu

exposure to asbestos.

Nishimura(1), Takemi
Otsuki(1)Functional analysis of
CD8+ lymphocytes inpatients with pleuralplaque or malignant
mesothelioma〇Naoko Kumagai-Takei,
Yasumitsu Nishimura,
Hidenori Matsuzaki, Suni
Lee, Takemi Otsuki(1)Department ofHygiene, Kawasaki
Medical School, Kurashiki,Japan , (2)Division ofBioscience, Graduate
School of Natural Scienceand Technology, Okayama
University, Okayama,Japan
Department of Hygiene,Kawasaki Medical School,Kurashiki, Japan(1)Lab. Funct.
Glycobiochem. Dept.

Alteration of cellularcharacterization caused bycontinuous exposure ofcrocidolite or chrysotile on
human T cell line

Biofunct. Chem., Div.
Agricult. Life Science,

Megumi Maeda(1), 〇Takemi
Graduate School ofOtsuki(2), Hidenori
Environmental and Life
Matsuzaki(2), Suni Lee(2),Science, Okayama
Naoko Takei(2), Yasumitsu
University, Okayama,
Nishimura(2)Japan , (2)Department ofHygiene, Kawasaki
Medical School, Kurashiki,Japan

Commercially available〇Masao Yamaguchi(1),drink-induced anaphylaxis: Yusuke Tanaka(1), Yuko
analyzed using basophil
activation test (BAT) andhistamine release test

(1)Division of Respiratory
Medicine and Allergology,Nakase(1), Naoya
Department of Medicine,Sugimoto(1), Takako
Teikyo University SchoolToda(1), Yasuhiro Kojima(1), of Medicine, (2)Publish
Asae Kamiyama(1), HisanaoYoshihara(1), Michio

Health Insurance
Association, (3)NationalKuramochi(1), Hiroyuki
Tashimo(1), Hidenori

Institute of HealthSciences, (4)NationalArai(1), Ayako Kawakami(2), Hospital Organization

Hiroshi Akiyama(3), Hiroyuki Tokyo National Hospital,Nagase(1), Ken Ohta(1),(4)Tokyo, Japan

Mechanisms of aggravation 〇Tomoki Fukuyama, Tadashi
atopic dermatitis byKosaka, Lisa Miyashita,
The Institute ofenvironmental
Risako Nishino,Koichi
Environmental Toxicology
immunosuppressive
chemicals in NC/Nga mice

Hayashi, Hideo Ueda,
Takanori Harada(IET), Ibaraki, Japan

Prior oral exposure toenvironmental〇Risako Nishino, Tomoki
immunosuppressive agents Fukuyama, Lisa Miyashita,
aggravates OVA allergeninduced allergic asthma in
NC/Nga mice

Koichi Hayashi, HideoUeda,Tadashi Kosaka

The Institute ofEnvironmental Toxicology,Ibaraki, Japan〇Rika Watanabe,Takahiro

School of Pharmaceutical

Sakuta, Mami Kawaguchi,Kuniaki Takagi, Masakuni

Science, University of
Shizuoka, Shizuoka,

DegawaJapan

Change of &beta-casein in
breast milk before andafter relaxation experience〇Yukina Ichiki Yukina ,Uehara Masashi , Masuda
Miyabi , Takagi Kuniaki ,School of Pharmaceutical
Science, University of
Shizuoka, Shizuoka,by thalassotherapy

Degawa Masakuni

Japan

Change of lactoperoxidasein saliva bythalassotherapy(1)Department ofPreventive Medicine,

The effects of tributyltin(TBT) on the mRNA
expressions of cytokines inthe splenic macrophages
and lymphocytes from theF1 rats exposed to TBT

Kitasato University Schoolof Medicine, Sagamihara,
Japan , (2)Department of〇Masashi Tsunoda(1),Takamasa Kido(2), Chiemi

Pulic Health andEnvironmental Medicine,Sugaya(1), Hiroshi
Katagiri(3), Yoshiharu

The Jikei University
School of Medicine, Tokyo,Aizawa(4)Japan , (3)Department ofPublic Health, Kitasato
University School of Allied
Health Sciences ,(4)Kitasato University,Tokyo, JapanCan measuring theexpressions of perforin,
granzymes and granulysin〇Qing Li, Maiko Kobayashi,
Hirofumi Inagaki, Yoko
Wakayama, Masao
Katsumata, Yukiyo Hirat ,alternative the assay of NK
Yingji Li, Kimiko Hirata,
activity in human
Takako Shimizu, Tomoyuki
peripheral lymphocytes?
KawadaDepartment of Hygieneand Public Health, Nippon
Medical School, Tokyo,Japan(1)Toxicology Laboratory,
Application of Human Cell
Line Activation Test (hCLAT) as a method fordetecting allergic potentialof drug candidates〇Mitsuhiro Uchida(1),Toshiyuki Tsuchiya(1), MahoUkaji(2), Yoshiro Saito(2),Kouichi Kurose(2)Pharmaceutical researchcenter, Meiji Seika PharmaCo., Ltd., Kanagawa,Japan , (2)Division of
Medicinal Safety Science,
National Institute of
Health Sciences, Tokyo,Japan

Students and Young Scientists Session

(1)Department ofHygienic Chemistry,
Faculty of PharmaceuticalScience, Tokyo Universityof Science, Noda, Chiba,
Japan , (2)Center of
Masakazu Umezawa(2), Saki
Environmental HealthOkamoto(1), Rikio Niki(2),Science Next Generation,
Shuhei Ogawa(2),(3), Shiho
RIST, Tokyo University ofWatanabe(3), Ryo Abe(3),Science, Noda, Chiba,Ken Takeda(1),(2)Japan , (3)Research〇Ryuhei Shimizu(1),Fetal exposure to carbon
nanoparticle altereddevelopment of theneonatal immune system

Institute for BiologicalSciences, Tokyo Universityof Science, Noda, Chiba,Japan(1)The Center for
Environmental Health
Science for the Next
Generation, RIST, Tokyo
University of Science,
Effect of fetal exposure tocarbon black nanoparticle〇Masakazu Umezawa(1),Noda, Chiba, Japan,

Ryuhei Shimizu(2), SakiOkamoto(2), Shiho(2)Department ofHygienic Chemistry,on splenic gene expression Watanabe(3), ShuheiFaculty of Pharmaceuticalin neonatal mouse

Ogawa(1),(3), Ryo Abe (3),Science, Tokyo University

Ken Takeda(1),(2)of Science, Noda, Chiba,Japan, (3)ResearchInstitute for BiologicalSciences, Tokyo Universityof Science, Noda, Chiba,Japan(1)Laboratory ofToxicology and Safety
Science, Graduate School○Toshiro Hirai(1), Yasuo
Yoshioka(1), Hedeki
The novel immunemodulating effects ofamorphous nanosilica
particles following
epicutaneous exposure

Takahashi(1), KO-ichi
Ichihashi(1), Nobuo
Nishijima(1), Tokuyuki
Yoshida(1), Shin-ichi
Tsunoda(2),(3), Hiromi
Nabeshi(4), Tomoaki
Yoshikawa(1), Yasuo
Tsutsumi(1),(2),(3)of PharmaceuticalSciences, Osaka
University, Osaka, Japan ,(2)Laboratory ofBiopharmaceutical
Research, National
Institute of Biomedical
Innovation (NiBio),Osaka, Japan , (3)MEI
center, Osaka University,Osaka, Japan ,(4)National Institute of
Health Science, Tokyo,Japan

Effect of Asian sand dust
particles on human airway〇Yugo Matsuda(1), Akiko
Honda(1), Rumiko(1)Environmental Health
Division, Department ofepithelial cells

Murayama(1), Kenshi

Environmental

Tsuji(1), Masataka
Engineering, Graduate
Nishikawa(2), Eiko Koike(3), School of Engineering,
Seiichi Yoshida(4), Takamichi Kyoto University, Kyoto,
Ichinose(4), Hirohisa

Japan , (2)Center for

Takano(1)Environmental

Mesurement and Analysis,
National Institute forEnvironmental Studies,
Tsukuba, Japan ,(3)Center for
Environmental HealthSciences, National
Institute forEnvironmental Studies,
Tsukuba, Japan ,(4)Department of HealthSciences, Oita University
of Nursing and Health
Sciences, Oita, japan
Luncheon Seminar 1
Evaluation of Anti-Drug
Antibodies During NonClinical Safety Studies

Gary Bembridge

Huntingdon Life Sciences
Ltd.

Luncheon Seminar 2
Principal Immunologist
Validation and use ofand Molecular Biologist,

several assays to monitor
pharmacodynamic markers Lawrence D Jacob

Bioanalysis andImmunology Group,

intended for human use, inCharles River Laboratories

the cynomolgus monkey

Preclinical services,
Edinburg