IMMUNOTOXICOLOGYSpecialty Section
2017-2018
Executive Committee
President
Victor J. Johnson

Winter Edition

President’s Message

Season’s greetings Immunotoxicologists! As we race into theholiday season, we need to take a smidgeon of time to remind
Vice President
ourselves that the 2018 Annual Meeting of the Society of Toxicology
Jamie DeWitt
is right around the corner. With only a couple months left to prepare,
there remains much work ahead. Many are preparing
Vice President-Elect
presentations, posters, CE lectures, and sessions following
Emanuela Corsiini
acceptance of their efforts for the 2018 SOT meeting. We are
excited to see what everyone has to share with fellow
Secretary/Treasurer
immunotoxicologists and the greater toxicology committee. Keep up
Stacey Anderson
the great work!
The ITSS Executive Committee and the many
Past President
subcommittees have been hard at work since the 2017 SOT
L. Peyton Myers
meeting. As I prefaced in the last newsletter, the committees havebeen working on several important goals for this term. I will not
Senior Councilorrehash these goals, but rather provide a little insight into theRodney Prell
progress that has been made.
Education and sharing of science is key to the success ofJunior Councilor
ITSS. The SOT meeting provides a showcase for our passion and it
Jessica Lynch
is charge of the ITSS membership to make an infectious showing,pun intended. With the 2018 SOT meeting fast approaching, thePostdoc Representative
deadline for program proposals for the 2019 meeting is fast on its
Angela Groves
heels. My most urgent plea in this respect is “don’t wait, do it now”.
You will be receiving more information on program in this newsletter
Student Representative
and additional notices by email over the coming weeks. Thanks for
Jiajun (Brian) Zhou
the hard work Program Committee! In an effort to stimulate
program, ITSS Executive Committee has revitalized and organized
The Immunotoxicology Specialty the “Scientific Advisory Committee” composed of current and past
Section (ITSS) Newsletter isleadership of the ITSS. The goal of this committee is to stimulate
published three times a year
ideas focusing on the 2019 round of program proposals. Look for(Summer, Fall, and Winter). If you communication from this committee in the coming weeks. Bring
would like to share an item ofyour best science to the forefront, and remember, we are here tointerest with members of the ITSS, help so please don’t hesitate to reach out.
please send it to theCommunications Committee Chair.
All comments and suggestions are President’s Message…………..………………………………….……1
ITSS Awards....................................................................................3
welcome.
Student Post-doctoral Committee Report ……..........……....….…..4International Collaboraton: EUROTOX………...….…….......….......5
Jiajun (Brian) Zhou
International Collaboraton: JSIT………..............….…….......….......6
zhoujiaj@msu.edu
Memorium.......................................................................................8
Angela Groves
Achievements…............................................................................10
Angela_Groves@URMC
Student Postdoc Mentoring Event….............................................11
Rochester.edu
Recent Immunotoxicology Publications.........................................12
Jessica Lynch
Job Posts.......................................................................................16
jlynch18@ITS.JNJ.com

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President’s Message
Exciting news! The Mitzi and Prakash Nagarkatti Research Excellence in Immunotoxicology Award
Fund is growing and contributions from the ITSS community are starting to come in. We are extremely
pleased to announce that in its inaugural year, this endowment fund is going to support its first travel award!
Best of luck to the budding students and post docs that are training to become the next generation of
immunotoxicologists. Your mentor will be very excited when you win the travel award so please apply, see theaward section below for details on this and other awards provided by ITSS. Sincerest gratitude to the
Nagarkatti’s for establishing the fund and to those who have helped the fund grow. Please make sure to readthe section below providing details on how you can help ensure that this fund matures.
The international exchange committee efforts of ITSS have been a success for another year. Dr.
Danuta Herzick was the ITSS delegate selected to provide a Special Lecture at the Japanese Society of
Immunotoxicology Annual Meeting this year. She gave an engaging lecture and will provide a summary of her
experiences in the pre-SOT newsletter in 2018. JSIT has graciously provided a letter for this newsletter
providing insight into their society, enjoy. In addition, a video presentation from ITSS (thanks Vic, Brian, andAngie) was presented at the JSIT meeting with goals of engaging the young Japanese immunotoxicologists.
Thanks for the idea and encouragement Kazu. The IEC is actively engaging immunotoxicologists in othercountries as well and look forward to sharing science.
December is the time of year for SOT to call for nominations for executive positions for the specialty
sections. Nominations for the positions of ITSS Vice President Elect and Junior Councilor are welcome (dueby December 31, 2017). Ballots from SOT will be appearing in your email inbox in January 2018. It is
important for everyone to contribute by voting for the future leaders of the ITSS.
There is some sad news in this edition as we mourn the loss of two colleagues that recently passed.
Memorials for Dr. Allen Silverstone and Dr. Susan Sarlo have been prepared by Dr. Michael Luster and Dr.
G. Frank Gerberick. Read the memorials and remember and honor the lives and careers of our fellow
immunotoxicologists, they will be missed.
It is time for me to stop talking and let you enjoy the rest of the newsletter. Thanks to everyone who
contributed for making this a great edition. Your feedback is always welcome. This is wishing everyone thebest for the holiday season. Have fun, celebrate, and stay safe.
Best regards,
Dr. Vic Johnson
President, ITSS 2017 - 2018

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2018 SOT ITSS Awards
Dear ITSS Colleagues,
We would like to remind you that the application deadline for the following awards is January 15, 2018:- Vos Lifetime Career Achievement Award in Immunotoxicology (Contact Vic Johnson;
vjohnson@brt-labs.com)- HESI Immunotoxicology Young Investigator Travel Award (Contact Vic Johnson; vjohnson@brt-labs.com)- Outstanding Young Immunotoxicologist Award (Contact Jamie DeWitt; dewittj@ecu.edu)- Outstanding Senior Immunotoxicologist Award (Contact Jamie DeWitt; dewittj@ecu.edu)- Best Paper of the Year (Contact Rodney Prell; prell.rodney@gene.com)- Best Presentation by a Postdoctoral Trainee Award (Contact Rodney Prell; prell.rodney@gene.com)- Best Presentation by a Student Award (Contact Rodney Prell; prell.rodney@gene.com)
In addition, we are very excited to announce the inaugural Mitzi and Prakash Nagarkatti Research
Excellence in Immunotoxicology Travel Award. This award is funded by the Mitzi and Prakash Nagarkatti
Research Excellence in Immunotoxicology Award Fund, an ITSS/SOT Endowment established in 2017. Thisaward, which will be $500, will assist graduate students or postdoctoral fellows in attending SOT andpresenting their research. Application deadline for this award is also January 15, 2018 and application should
be sent to Vic Johnson (vjohnson@brt-labs.com). Applicants should submit their CV, recommendation letterfrom their supervisor and a brief letter from the applicant describing the importance of receiving this award totravel to the SOT Annual Meeting and how it will impact their career in Immunotoxicology.
We would like to encourage all of you to nominate deserving colleagues for these awards. We would
especially like to encourage all eligible students and postdocs to apply for the Student and Postdoctoral
Trainee Awards.
For more information and application requirements, please refer to the ITSS website:
http://www.toxicology.org/groups/ss/imtox/deadlines.asp
Best regards,
Rodney Prell
ITSS Senior Councilor

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Student & Postdoctoral Report
Dear graduate students and postdocs,
We hope you have had a wonderful 2017.
It’s hard to believe, but SOT’s 57th annual meeting in San Antonio, Texas is not too far away! With that inmind, now is the time to be thinking about applying for those travel awards. The ITSS has several awards
for graduate students and postdocs that you can take advantage of. The deadline for all of these awards is
January 15th, so you still have time to apply!
The awards available for graduate students are:Best Presentation by a Student Award
Best Paper of the Year Award
Prakash Nagarhatti Research Excellence in Immunology Award
The awards available for postdocs are:Best Presentation by a Postdoctoral Trainee Award
Best Paper of the Year AwardHESI Immunotoxicology Young Investigator Travel Award
Prakash Nagarhatti Research Excellence in Immunology Award
Many other travel awards are also available to students through the SOT’s multiple Specialty Sections andSpecial Interest Groups. Visit SOT’s website for more details.
We would like to encourage students and postdocs to attend the Graduate Student/Postdoc Mixer and the
4th Annual ITSS Networking/Mentoring Event at the Annual Meeting (time and location information to beannounced soon). This event gives participants the opportunity to interact with diverse panelists fromacademia, industry and government. The participants are able to connect with these experts to learn about
what it is like to hold their positions and ask advice on career planning. Our tremendous group of mentors
made last years event a success, and we are excited to be able to provide another great line up this year.
We also encourage the ITSS graduate student and postdoc members to participatie in the ITSS
committees. This is a great way to become involved with other ITSS members and to enhance yourprofessional network. There are 4 different committees within ITSS: Awards, Program, Education andCommunication/Membership, each chaired by friendly and motivated members of the ITSS executive
committee. Participating in these activities can be rewarding and it is also great opportunity to get to know
the immunotoxicological community. If you would like to get more involved please contact us atAngela_Groves@URMC.Rochester.edu or zhoujiaj@msu.edu.
We wish you a joy-filled new year.
Angela Groves, Ph.D.

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International Collaborations: EUROTOXON THE OTHER SIDE OF THE POND: IMMUNOTOXICOLOGY AND CHEMICAL ALLERGY SPECIALTY
SECTION (ITCASS) AT EUROTOXIn brief, EUROTOX’s interest interested in immunotoxicology, chemical allergy is exemplified andfood allergy through educational activities that emphasize fundamental development and application in
immunotoxicology, chemical allergy and food allergy, planning and contribution with scientific programmes(e.g. workshops, symposia, continuous education courses) held during the EUROTOX annual congress.
ITCASS goal is to have at least one immunotoxicology symposium or workshop for every day of thecongress. This of course requires the submission of attractive, well-structured proposals to the ScientificCommittee responsible for the scientific program. The call of proposal usually starts in December. As for
ITSS for SOT, also ITCASS is doing a pre-screening asking members to pre-submit their proposals to
ITCASS in order to improve them if needed and send the best to EUROTOX. This increases the chance ofbeing accepted.
In addition, ITCASS aims to promote by any means immunotoxicology as a discipline by increasing
our understanding of the impact of xenobiotics on the immune system, by a better understanding of themechanisms of immunomodulation, and by encouraging the development of new methods and techniques
to improve risk assessment.
Besides the annual face to face meeting that takes place during the annual EUROTOX congress,
ITCASS also organises approximately every two year an informal two-days congress. The last one was inChâtenay-Malabry/Paris in November 2016, while the previous were in Elsinore, Denmark (2012); Den
Bosh, The Netherlands (2010); Oslo, Norway (2008); Lodi, Italy (2006); Manchester, UK (2004); Paris,
France (2002); Bilthoven, The Netherlands (2000). These meetings are very well attended, with excellent
presentations and lively discussion.
Similarly, to the Japanese Society of Immunotoxicology, we wish that the collaboration between
ITCASS and ITSS will increase in the near future, and join symposium/workshop/CEC will be organized.
Emanuela Corsini and Marc Pallardy

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Immunotoxicology Specialty Section

International Collaborations: JSIT
Report on the 24th Annual Meeting of the Japanese Society of Immunotoxicology
The 24th Annual Meeting of the Japanese Society of Immunotoxicology (JSIT) was held on September
4th - 5th, 2017 at the School of Veterinary Medicine, Kitasato University in Towada, Aomori. I would like tothank my seniors and colleagues of the Immunotoxicology Specialty Section (ITSS) for the great support.
The theme, “New perspective of immunoenhancement and immunosuppression” was set as the main
theme of the meeting by myself. Autoimmunity or allergy is not necessarily initiated by“immunoenhancement”, but can be caused by even immunosuppression or normal immunity simply
recognizing altered-self antigen or MHC. I intended to discuss and to disseminate this new aspect of
immunotoxicity in the meeting. In addition, I thought that we should consider the physiological (normal) stateof “immunosuppression”. In this connection, a symposium titled “Reproductive immunotoxicology:
Immunological mechanism of pregnancy and its breakdown” was presented. Immunotoxicity was discussed
from new perspectives in this meeting.
The meeting was started with the keynote lecture by Dr. Jack H. Dean. I asked him at the last ITSS
meeting in March, 2017 to give a lecture for JSIT members. He kindly provided permission to play his video
lecture from Eminent Toxicologist Lecture Series at the JSIT meeting and later sent the abstract of his lecture.
Dr. Jack H. Dean had never appeared in our previous meetings, but I was thinking for a long time that heshould be invited to present the keynote lecture. To my honor and proudness, he accepted my invitation andprovided the keynote lecturer “Immunotoxicology: A historical perspective” for the 2018 JSIT meeting.
Immunotoxicology was established by his pioneering works and vast achievements. To explore the newperspective today I thought his lecture would be of great benefit for the JSIT members and I wanted
especially the next generation to know his challenges to create a new perspective in toxicology nearly a half
century ago. The lecture gave very impressive messages to audiences. I am so pleased that his name has
been inscribed in the history of our JSIT.
I was also lucky and honored to be the meeting president which provided me the opportunity to invite
Dr. Danuta Herzyk as part of the researcher exchange program between the ITSS and JSIT. As I used to work
for a pharmaceutical company, she and I are sharing similar views on immunotoxicology. I had been longing
to have her lecture in a JSIT meeting, and finally my dream came true. I really appreciate Dr. Mitch Cohen for
his efforts on this project. Without him, my dream would still be a dream. Her lecture “Immunotoxicity
Assessment of Biopharmaceuticals” received great attention from audiences because it was well prepared
being based on the data and experiences in her immunotoxicological research.
Another special lecture was presented by Dr. Tsuyoshi Yokoi from Nagoya University, who is now adistinguished researcher on the immunology of drug-induced liver injury (DILI). He reported his works andclearly explained involvement of Th17 cells and TLR4 of Kupffer cells in the liver injury. His works are
expected to improve the poor predictability of animal experiments for the idiosyncratic DILI.
Dr. Takeharu Minamitani from National Institutes of Biomedical Innovation, Health and Nutrition gave an
educational lecture on autoimmune diseases. In his current study, he demonstrated the molecularpathogenesis by which Epstein-Barr virus infection induces autoimmune diseases. He showed us that
EBV-encoded LMP2A mimics B-cell antigen receptor signaling in murine germinal center B cells causing
systemic lupus erythematosus-like autoimmune phenotypes.
The symposium “Reproductive immunotoxicity: Immunological mechanism of pregnancy and its
breakdown” discussed the immunological tolerance and placenta formation during pregnancy. Since mothers
should accept fetus alloantigen, immunological mechanisms should properly work for successful pregnancy.
Abortion and eclampsia may be caused by immunotoxicity of xenobiotics. The symposium focused on
Th1/Th2 balance, the roles of Treg, gamma/delta T cells and uNK cells during pregnancy. The
immunotoxicological effects of nano-silica on pregnancy was also presented.

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International Collaborations: JSIT
The workshop dealt with safety evaluation method of biopharmaceuticals (protein formulation) with theperspectives of regulatory agency and industry. Expectation of in vitro studies to support in vivo studies andimmunogenicity assessment of antibody/antibody-drug conjugate therapeutics were main topics in theworkshop. Interpretation of ICH S6 (R1) guideline was also mentioned by the PMDA.
Among 11 oral and 22 poster presentations, the Best Presentation Award went to Dr. Masashi
Tachibana from Osaka University presenting “Regulation of myeloid-derived suppressor cells by glutamate
signaling” and the Students and Young Scientists Award to Dr. Toshiyuki Ohtake from Chemicals Evaluation
and Research Institute presenting “Comparison of skin sensitization potential of isocyanates by a local lymph
node assay and an integrated testing strategy with an in silico, in chemico and in vitro assays”, respectively.
As part of this year program, I gave a big surprise to my JSIT colleagues. It was plotted in collaboration with
Dr. Victor J. Johnson who gave a lecture at the last year’s JSIT annual meeting. He sent me three video
messages to be shown in the evening banquet on the first day of the meeting. Dr. Victor J. Johnson
introduced ITSS current activities as the ITSS president. Jiajun (Brian) Zhou also appeared talking about the
ITSS Newsletter as the ITSS graduate student representative, while Dr. Angela Groves explained the ITSS
annual immunotoxicology mentoring event as the ITSS post-doctoral representative. Very big cheers rosefrom the banquet participants. The plot was successful! I would like to thank those great people.
The meeting gathered about 100 attendees. Since the JSIT encourages enthusiastic participation ofresearchers especially from the next generation and the JSIT members know each other well, the discussion
was very active in very friendly atmosphere. I would like to once again express my sincere gratitude for the
support from ITSS and your friendship. Thank you very much.
Please visit http://www.immunotox.org/annualmeeting/24/photo.html to see photos of the meeting.
Kazuichi Nakamura, D.V.M., Ph.D.
President of the 24th JSIT Annual Meeting
Kitasato University

Picutres from the JSIT annual meeting:

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Immunotoxicology Specialty Section

Memorium
It is an honor to write a remembrance letter for my friend andcolleague, Dr. Katherine Sarlo, who passed away in March after
courageously fighting a long-term illness. Kathy was born in
Brooklyn, NY. She attended the State University of New York-Stony
Brook where she received a BS in Biology and then later obtained
her PhD in Microbiology and Immunology from The Ohio State
University. In 1985, she started a distinguished career at the Procter& Gamble Company, working in the field of respiratory allergy.
Kathy contributed major insights and methods for assessing
the respiratory sensitization potential of chemicals and proteins. She
published a novel tiered approach for evaluating the respiratory
allergenicity of low molecular weight chemicals that was widely cited
and adopted. The approach allowed one to rank order chemicals
based on their respiratory allergy potency which was beneficial forrisk assessment purposes. Kathy was very proficient in use of in vivo
models for respiratory allergy assessments, specifically the guinea
pig intratracheal model. She also contributed significantly to thedevelopment of the mouse intranasal model and showed its utility in determining allergenic potency ofdetergent enzymes and other proteins. Kathy made important contributions to control of occupational asthma
and allergy in the detergent industry. She showed that proteolytic detergent enzymes enhance allergic
antibody responses of guinea pigs to non-proteolytic enzymes in a mixture that was critical information for
setting occupational guidelines. Kathy was very proud of her work that contributed to development ofguidelines for the handling of enzymes to assure their safe use, both occupationally and in consumer
products. One of Kathy’s more significant pieces of work was designing a robust testing strategy that, in theend, showed an enzyme-containing personal cleansing product was not safe to proceed to market. One of
Kathy’s many virtues were her outstanding ability to collaborate with scientists from around the world. I know
many of the scientists she collaborated with - whether colleagues from P&G or scientists from academia,
government, or industry - loved working with her because she was an expert in her field, never afraid to speak
up for what she thought was right in terms of either science or relationships, and so much fun to be around.
In addition to Kathy’s scientific side, she was a creative and talented artist. After her retirement from
P&G, she continued to develop her love for painting and photography. On more than a few occasions, hercreative work was shown in galleries around the Cincinnati area. She also loved to travel and spend time withher beloved husband, Christopher G. Schleifer. I would say that what defined Kathy best was her love forfamily and friends, and boy did her family and friends love her.
Kathy will be missed by so many but not forgotten. For me, her legacy will be less about her scientificachievements and more about remembering her amazing personality and friendship.
G. Frank Gerberick

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Immunotoxicology Specialty Section

Memorium
The toxicology and immunology community mourns the passingof Allen (Al) E. Silverstone. He leaves behind his loving son David andwife Barbara, a lifetime of scientific achievement, social activism, andan international community of colleagues, collaborators and admirers.
Al conducted his undergraduate work at Reed College (BS 64) and his
graduate work at MIT (Ph.D. 70). He was on the faculty for many years
at SUNY Upstate Medical University where he taught and conducted
research in Immunotoxicology focusing on T cell immunity, dioxins,
and the Ah receptor. Whether at meetings, dinners, or at the local
watering hole, Al was fond of talking about his current research,environmental justice, scientific topics of the day, and even his
graduate school days with his mentor David Baltimore, and their workon terminal deoxynucleotidyl transferase. Students and colleagues
who worked with Al admired his scientific tenacity, ethics, and tirelesswork for excellence in research.
For those of us that knew him, he will always be remembered asa gentle, kind, thoughtful man.

Allen E. Silverstone(Sept. 20, 1942 - Nov. 19, 2017)

Michael I. Luster

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Achievements

C o n t r a g u l a t i o n s

Congratulations to Allison Ehrlich, PhD, forwinning a K99 Pathway to IndependenceAward from the National Institute of
Diabetes and Digestive and Kidney Diseases
for her grant titled "AhR activation andsusceptibility to type 1 diabetes”.

December 201710

Immunotoxicology Specialty Section

Announcement

Immunotoxicology Specity Section

Networking/Mentoruing Event

2018 information:
Date: Tuesday, March 13th
Location: TBA
Time: 4:00 - 5:00 pm
We can not wait to fill you in with more updated information about the event.

$$$

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Immunotoxicology Specialty Section

Member Spotlight
An interview with Dr. Emanuela Corsini

When did you begin your career in immunotoxicology and what do you
currently do?
It was 1988 when my boss Corrado Galli decided that we should start to workin the field of immunotoxicology, at that time a new area of investigation. I spent six
months at the Mario Negri Institute in Milan to learn how to work in the field of
immunology under the supervision of Annunciata Vecchi. Then, I joined at the end of
August 1989 the Laboratory of Immunotoxicology, directed by Mike I. Luster at the
NIEHS in North Carolina, under the supervision of Gary Rosenthal. This was mystart, and since then I have been working in the field of immunotoxicology.
Currently, the primary focus of my laboratory centres on the refinement of alternative in vitro tests to
identify and discriminate contact allergens from irritants and respiratory sensitizers, based on the use of
DC-like cells and keratinocytes, and to classify allergens according to their potency. The other area of
research is on the understanding at the molecular level the mechanism of action of
immunotoxic/immunomodulatory compounds (i.e. perfluorinated compounds, pesticides, vegetal extracts) on
innate and adaptive immunity. Finally, immunosenescence represents the other area of interest of mylaboratory. Specifically, studies are being conducted to define the role of RACK1 and protein kinase C in the
decline or remodelling of the immune responses associated with aging, and to identify compounds able toreverse such changes (i.e. DHEA, natural extracts). Close to this, it is the recent interest on endocrine
disruptors, as we have data that support their ability to modulate RACK1 expression and innate immunity.
When did you start participating in the ITSS?
Long time ago, my first SOT was in Miami I believe in 1991. I joint SOT and ITSS as in 1993.
What was you most rewarding experience involving ITSS or ITCASS at Eurotox?
Of course, the most rewarding experience, besides being elected last March in Baltimore as President
elect, it was when in 2004 I received Outstanding Young Investigator Award.
Regarding ITCASS at EUROTOX, I still remember when together with Jacques Descotes, Henk Van Loveren
and Ian Kimber, we sit down to discuss the by-laws drafted by Jacques and started the Speciality Section. In
ITCASS, I have served as Secretary, Councilor and President (or better to say Chair as we call us at
EUROTOX, being the title President reserved for the President of EUROTOX!!!), and I am still very involved.
Although I no longer have official positions, I am actively involved in preparing proposals for the annual
congress and in the dissemination of immunotoxicology as a central discipline in assessing the safety ofxenobiotics.
What has been the largest benefit, for you, of being an active participant in an SOT SS like the
ITSS or ITCASS?
I think the largest benefit, it is to see and confront with others on issues of interest in the field of
immunotoxicology, and emerging issues. An extremely useful way of updating on how immunotoxicology ismoving globally.
Do you have any advice for someone who is considering becoming more involved in an SS?
Having served as a member of the executive committees of IUTOX (2010-2016) and EUROTOX (2014 – topresent), I realized how this is fundamental to opening the mind, knowing different realities, and establishingconnections that will last forever. Engaging means contributing to the good and to the interest of our scientificcommunity: if you do not actively participate then you cannot then complain if things do not go as well as you
wish.
What is one fun fact about yourself that you would like to share with others?
When I was at the NIEHS, I still remember when during the Branch meeting when it was my turn to present
my research, my supervisor introduced me as Emanuela Corsini from the University of Brooklyn, as to say
attention to the accent as one of Little Italy!!! Absolutely true, I still got a very strong Italian accent.

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Immunotoxicology Specialty Section

Recent Immunology Publications
Compiled by Angela Groves and Jiajun (Brian) Zhou. Anytime you have a new fully-published orelectronically available article to report, please send the citation to Angela atangela_groves@urmc.rochester.edu.
Asthma, Allergy, Autoimmunity & Hypersensitivity
Galbiati, V., Papale, A., Marinovich, M., Gibbs, S., Roggen, E. and Corsini, E., 2017. Development of an invitro method to estimate the sensitization induction level of contact allergens. Toxicology Letters, 271,
pp.1-11.
Gibbs, S., Kosten, I., Veldhuizen, R., Spiekstra, S., Corsini, E., Roggen, E., Rustemeyer, T., Feilzer, A.J. andKleverlaan, C.J., 2017. Assessment of metal sensitizer potency with the reconstructed human epidermis
IL-18 assay. Toxicology, 393, pp.62-72.
Johansson, E., Boivin, G.P. and Yadav, J.S., 2017. Early immunopathological events in acute model of
mycobacterial hypersensitivity pneumonitis in mice. Journal of immunotoxicology, 14(1), pp.77-88.
Kuroda, Y., Yuki, T., Takahashi, Y., Sakaguchi, H., Matsunaga, K. and Itagaki, H., 2017. Long form of thymic
stromal lymphopoietin of keratinocytes is induced by protein allergens. Journal of Immunotoxicology, 14(1),pp.178-187.
van Vliet, E., Kühnl, J., Goebel, C., Martinozzi-Teissier, S., Alépée, N., Ashikaga, T., Blömeke, B., del Bufalo,A., Cluzel, M., Corsini, E. and Delrue, N., Consensus Report State-of-the-art and new options to assess T cell
activation by skin sensitizers: Cosmetics Europe Workshop.
Developmental Immunotoxicolgy
Grandjean, P., Heilmann, C., Weihe, P., Nielsen, F., Mogensen, U.B., Timmermann, A. and Budtz-Jørgensen,
E., 2017. Estimated exposures to perfluorinated compounds in infancy predict attenuated vaccine antibody
concentrations at age 5-years. Journal of immunotoxicology, 14(1), pp.188-195.
Nicholson, S.M., Carlesso, G., Cheng, L.I., Cook, H., DaCosta, K., Leininger, J., McKeever, K., Taylor, D.,
Streicher, K., Eck, S. and Reed, M., 2017. Effects of ICOS+ T cell depletion via afucosylated monoclonal
antibody MEDI-570 on pregnant cynomolgus monkeys and the developing offspring. Reproductive
Toxicology, 74, pp.116-133.
General Immunotoxicology
Bhatti, S.A., Khan, M.Z., Saleemi, M.K., Saqib, M., Khan, A. and ul-Hassan, Z., 2017. Protective role ofbentonite against aflatoxin B1-and ochratoxin A-induced immunotoxicity in broilers. Journal of
immunotoxicology, 14(1), pp.66-76.
Bouallegui, Y., Ben Younes, R., Turki, F. and Oueslati, R., 2017. Impact of exposure time, particle size anduptake pathway on silver nanoparticle effects on circulating immune cells in mytilus galloprovincialis. Journalof Immunotoxicology, 14(1), pp.116-124.
Buoso, E., Galasso, M., Ronfani, M., Papale, A., Galbiati, V., Eberini, I., Marinovich, M., Racchi, M. andCorsini, E., 2017. The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with
important implication in immunity. Toxicology and applied pharmacology, 325, pp.37-47.

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Recent Immunology Publications
General Immunotoxicology
Buoso, E., Galasso, M., Ronfani, M., Serafini, M.M., Lanni, C., Corsini, E. and Racchi, M., 2017. Role ofspliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol anddehydroepiandrosterone. Pharmacological research, 120, pp.180-187.
Buoso, E., Galasso, M., Serafini, M.M., Ronfani, M., Lanni, C., Corsini, E. and Racchi, M., 2017.
Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones andsignificance in health and aging. Cellular Signalling, 35, pp.264-271.
Castano, R., Yucesoy, B., Johnson, V.J., Castellanos, L. and Cartier, A., 2017. Inflammatory proteins in nasal
lavage of workers exposed to occupational agents. Clinical & Experimental Allergy, 47(12), pp.566–1573.
Cetkovic-Cvrlje, M., Thinamany, S. and Bruner, K.A., 2017. Bisphenol A (BPA) aggravates multiple low-dose
streptozotocin-induced Type 1 diabetes in C57BL/6 mice. Journal of immunotoxicology, 14(1), pp.160-168.
Corsini, E., Ozgen, S., Papale, A., Galbiati, V., Lonati, G., Fermo, P., Corbella, L., Valli, G., Bernardoni, V.,
Dell’Acqua, M. and Becagli, S., 2017. Insights on wood combustion generated proinflammatory ultrafine
particles (UFP). Toxicology letters, 266, pp.74-84.
Corsini, E., Vecchi, R., Marabini, L., Fermo, P., Becagli, S., Bernardoni, V., Caruso, D., Corbella, L.,
Dell'Acqua, M., Galli, C.L. and Lonati, G., 2017. The chemical composition of ultrafine particles andassociated biological effects at an alpine town impacted by wood burning. Science of The Total Environment,
587, pp.223-231.
Ehrlich, A.K., Pennington, J.M., Bisson, W.H., Kolluri, S.K. and Kerkvliet, N.I., 2017. TCDD, FICZ, and otherhigh affinity AhR ligands dose-dependently determine the fate of CD4+ T cell differentiation. Toxicological
Sciences.
Ehrlich, A.K., Pennington, J.M., Tilton, S., Wang, X., Marshall, N.B., Rohlman, D., Funatake, C., Punj, S.,
O'Donnell, E., Yu, Z. and Kolluri, S.K., 2017. AhR activation increases IL‐2 production by alloreactive CD4+
T cells initiating the differentiation of mucosal‐homing Tim3+ Lag3+ Tr1 cells. European Journal of
Immunology, 47(11), pp.1989-2001.
Fallahi, S., Mohammadi, S.M., Tayefi Nasrabadi, H., Alihemmati, A., Samadi, N., Gholami, S., Shanehbandi,
D. and Nozad Charoudeh, H., 2017. Impact of C-rel inhibition of cord blood-derived B-, T-, and NK cells.
Journal of immunotoxicology, 14(1), pp.15-22.
Farris, B.Y., Antonini, J.M., Fedan, J.S., Mercer, R.R., Roach, K.A., Chen, B.T., Schwegler-Berry, D., Kashon,
M.L., Barger, M.W. and Roberts, J.R., 2017. Pulmonary toxicity following acute coexposures to diesel
particulate matter and α-quartz crystalline silica in the Sprague-Dawley rat. Inhalation Toxicology, 29(7),pp.322-339.
Henriquez, J.E., Rizzo, M.D., Schulz, M.A., Crawford, R.B., Gulick, P. and Kaminski, N.E., 2017. Δ
9-tetrahydrocannabinol suppresses secretion of IFNα by plasmacytoid dendritic cells from healthy andHIV-infected individuals. JAIDS Journal of Acquired Immune Deficiency Syndromes, 75(5), pp.588-596.

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Recent Immunology Publications
General Immunotoxicology
Kastelein, T., Duffield, R. and Marino, F., 2017. Human in situ cytokine and leukocyte responses to acutesmoking. Journal of immunotoxicology, 14(1), pp.109-115.
Kavasi, R.M., Berdiaki, A., Spyridaki, I., Corsini, E., Tsatsakis, A., Tzanakakis, G. and Nikitovic, D., 2017. HA
metabolism in skin homeostasis and inflammatory disease. Food and Chemical Toxicology.
Kawabata, K., Matsuzaki, H., Nukui, S., Okazaki, M., Sakai, A., Kawashima, Y. and Kudo, N., 2017.
Perfluorododecanoic Acid Induces Cognitive Deficit in Adult Rats. Toxicological Sciences, 157(2),pp.421-428.
Laue, H., Kern, S., Badertscher, R.P., Ellis, G. and Natsch, A., 2017. p-Alkyl-benzoyl-CoA conjugates as
relevant metabolites of aromatic aldehydes with rat testicular toxicity–studies leading to the design of a safer
new fragrance chemical. Toxicological Sciences, 160(2), pp. 244-255.
Li, J., Bhattacharya, S., Zhou, J., Phadnis-Moghe, A.S., Crawford, R.B. and Kaminski, N.E., 2017. Aryl
Hydrocarbon Receptor Activation Suppresses EBF1 and PAX5 and Impairs Human B Lymphopoiesis. The
Journal of Immunology, 199(10), pp.3504-3515.
Li, J., Phadnis-Moghe, A.S., Crawford, R.B. and Kaminski, N.E., 2017. Aryl hydrocarbon receptor activation
by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin impairs human B lymphopoiesis. Toxicology, 378, pp.17-24.
Li, Q., Zhang, P., Yu, X., Zhao, Y., Li, Q., Zhang, Y., Yang, Z., Xie, Y., Xue, P., Sun, S. and Jia, X., 2017. Leadtransiently promotes granulocyte-macrophage progenitor differentiation and subsequently suppresses
common myeloid progenitor differentiation. Toxicological Sciences, 160(2), pp. 268-283.
Qamsari, E.S., Sharifzadeh, Z., Bagheri, S., Riazi-Rad, F., Younesi, V., Abolhassani, M., Ghaderi, S.S.,
Baradaran, B., Somi, M.H. and Yousefi, M., 2017. Isolation and characterization of anti c-met single chain
fragment variable (scFv) antibodies. Journal of immunotoxicology, 14(1), pp.23-30.
Racchi, M., Buoso, E., Ronfani, M., Serafini, M.M., Galasso, M., Lanni, C. and Corsini, E., 2017. Role ofHormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence.
International journal of molecular sciences, 18(7), p.1453.
Ustarroz-Cano, M., Garcia-Pelaez, I., Cervantes-Yepez, S., Lopez-Valdez, N. and Fortoul, T.I., 2017. Thymic
cytoarchitecture changes in mice exposed to vanadium. Journal of immunotoxicology, 14(1), pp.9-14.
Wahlang, B., Barney, J., Thompson, B., Wang, C., Hamad, O.M., Hoffman, J.B., Petriello, M.C., Morris, A.J.
and Hennig, B., 2017. PCB126 exposure increases risk for peripheral vascular diseases in a liver injury
mouse model. Toxicological Sciences, 160(2), pp. 256-267.
Zhang, Y., Lickteig, A.J., Csanaky, I.L. and Klaassen, C.D., 2017. Clofibrate decreases bile acids in livers ofmale mice by increasing biliary bile acid excretion in a PPARα-dependent manner. Toxicological Sciences,160(2), pp. 351-360.

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Recent Immunology Publications
Methods/Models
Brown, M.R., Garside, H., Thompson, E., Atwal, S., Bean, C., Goodall, T., Sullivan, M. and Graham, M.J.,
2017. Development and application of a dual rat and human AHR activation assay. Toxicological Sciences,160(2), pp. 408-419.
Henriquez, J., Zhou, J., Li, J., Crawford, R. and Kaminski, N., 2017. Application of gene specific mRNA level
determinations in individual cells using flow cytometry-based PrimeFlow™ in immunotoxicology. Toxicology
and Applied Pharmacology, 337, pp.39-44.
DeWitt JC, Germolec DR, Luebke RW, and Johnson VJ. (2016). Associating Changes in the Immune Systemwith Clinical Diseases for Interpretation in Risk Assessment. In: Current Protocols in Toxicology(67:18.1.1-18.1.22).
Reviews/Books/Commentaries
Agúndez, J.A., Selinski, S., Corsini, E., Golka, K. and García-Martín, E., 2017. Biomarkers in drug
hypersensitivity. Frontiers in pharmacology, 8, p.348.
Derelanko, M.J., 2017. The toxicologist's pocket handbook. CRC Press.
Han, W., Tian, Y. and Shen, X., 2017. Human exposure to neonicotinoid insecticides and the evaluation of
their potential toxicity: an overview. Chemosphere.
Wolf, Jayanthi. (2018) Immunopharmacology and Immunotoxicology Assessment of Vaccines and Adjuvants.
In: McQueen, C. A., Comprehensive Toxicology, Third Edition. Vol. 11, pp. 852 – 872. Oxford: Elsevier Ltd

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Job Posts
Boehringer Ingelheim Endowed Chair in Mechanistic Toxicology
The School of Pharmacy at the University of Connecticut invites qualified candidates to apply for the positionof Boehringer Ingelheim Endowed Chair in Mechanistic Toxicology within the Department of Pharmaceutical
Sciences. This is a full-time (9-month appointment) tenure track position at the Associate or Full Professor
level.
Duties and Responsibilities:
We are seeking a scientist with a strong background in the field of mechanisms of tissue injury with a focus
on prevention, early detection or novel treatments. Preference will be given to investigators with expertise inimmunotoxicology or respiratory toxicology and how biotherapeutic options in these areas (e.g. monoclonal
antibodies, siRNA, viral vectors) impact patient safety. We are also interested in other emerging research
fields in mechanistic toxicology such as epigenetic regulation, genetic determinants of susceptibility tohepatotoxicity, transcriptomics, metabolomics, mechanisms of chemical-induced hepatocarcinogenesis andnon-coding RNA regulation. The successful candidate will be expected to contribute to research andscholarship (approximately 60% of time) through extramural funding, high quality publications, and impact asmeasured through citations, and to sustain national and international recognition as a scholar.
To Apply: Please visit https://academicjobsonline.org/ajo/jobs/10541 to apply and to view the complete job
description (Search #2018258). Screening of applications will begin on January 20, 2018 and will continue
until the position is filled.

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Immunotoxicology Specialty Section