Immunotoxicology Specialty
Section Newsletter
Incoming President’s Message
Submitted by Rafael A. Ponce, PhD.
2015-2016
Executive Committee
President
Rafael A. Ponce
Vice President
L. Peyton Myers
Vice President-Elect
Victor J. Johnson
Secretary-Treasurer
Kristen A. Mitchell
Past President
Danuta J. Herzyk

Senior Councilor
Cheryl E. Rockwell
Junior Councilor
Haley Neff-LaFord
Postdoc Representative
Ashwini S. Phadnis-Moghe
Student Representative
Aimee E. Hillegas
The ImTox SS Newsletter ispublished 3 times/year (Summer,
Fall, and Winter). If you would like toshare an item of interest withmembers of the ImTox SS, please
send it to the Communications
Committee Co-Chairs. All commentson, or suggestions to the newsletterare welcome.

Ashwini S. Phadnis-Moghephadnisa@msu.edu
Kristen A. Mitchell
kristenmitchell@boisestate.edu

Summer 2015

As I gather my thoughts after the celebration of the
30th birthday of the ITSS at the SOT Annual Meeting, I am
incredibly proud of how our members and the discipline ofimmunotoxicology are so prominently impacting public health, thedevelopment of new treatments for serious disease, and incontributing to basic science. These vital contributions, and thegrowing prominence of our discipline in many areas of publichealth, research, and clinical practice, are placing increasing
demands on us as we consider how to stay current with recent
research and evolving methods, and the novel technologies thatpress against the bounds of our understanding. This pace ofchange and the access to information challenge us to remaincurrent, and the ITSS Executive Committee is committed toensuring that we are evolving new ways for our members to stay
informed and to recognize our members for outstandingachievements and contributions as immunotoxicologists.
Last year, under the leadershipof Danuta Herzyk, the ITSS streamlined its
structure under four Committees (Awards,
Communication & Membership, Education,
and Program) and generated Best Practice
Guides for activities and responsibilities ofAwards Committee and Program Committee.
In addition, the ITSS initiated a new “Mentor –Student/Postdoc Event” with a pilot meetingorganized prior to the Annual Reception.
Dr. Rafael Ponce
President, ITSS
2015-2016

Incoming President’s Message………….…………………………….1
Outgoing President’s Message..………………………………………2
Student Postdoctoral Report ………………………………....….…....3
ImTox SS Committee Lists……………...……………………………..4
Job Opportunities.................................................................................5Awards Committee Report…………..………………………………...7
News and Noteworthy........................................................................11
Recent Immunotoxicology Publications…………………………...12
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Immunotoxicology Specialty Section

This event provided an informal discussion between young career scientists (students andpost-docs) and established scientists practicing immunotoxicology in academia, government,
contract research, and industry (thanks Ashwini!). In addition to these achievements, the ITSS
was prominent as a contributor to the scientific program at the Annual Meeting with three
symposia, two CE courses and workshops (each), and a roundtable. The contributions fromour membership to the Annual Meeting were truly outstanding
The ITSS Executive Committee is composed of both returning members, whoprovide continuity, and new members, who bring fresh ideas to the table. We congratulate andwelcome Victor Johnson (as VP Elect), Kristen Mitchell (Secretary-Treasurer, Communications& Membership Committee Co-Chair) and Haley Neff-LaFord (Junior Councilor) as newly
elected members of the Executive Committee. Thank you for your engagement andinvolvement with our Specialty Section. We also recognize the achievements and contributions
made by Danuta Herzyk (who is now Past President, Councilor) and Jamie DeWitt (whoretired from the ITSS as Senior Councilor). It is inspiring to me to have been able to work
closely with both of you. Thank you for your efforts to shepherd our Specialty Section into its
fourth decade!
Turning to the year ahead, the ITSS leadership and Committees are considering
new opportunities for member engagement, education, and interaction. Of particular interest
are new opportunities for basic and advanced education opportunities in immunotoxicology,
outreach to new members, and collaboration (both externally and with other SOT committees
and specialty sections). The primary mission of our specialty section is to ensure that ourmembers have the means to interact and thrive, tap into our collective expertise, and share
new research insights. While we have an active and engaged Executive Committee, we
encourage and welcome your input and involvement. Please feel free to contact any of us on
the Executive Committee if you have thoughts or concerns.
In addition, if you have news, including article submissions or publications, thatyou would like to share with our community, please send to Ashwini Phadnis(phadnisa@msu.edu) or Kristen Mitchell (kristenmitchell@boisestate.edu), as Co-Chairs of theCommunications and Membership Committee. On behalf of the ITSS Executive Committee,
we look forward to another productive and inspiring year for our specialty section. Many
thanks for all you do to make our group so very special.
Rafael Ponce, PhD
President, ITSS (2015-2016)

Outgoing President’s Message
Submitted by Danuta Herzyk, Ph.D
It was a great honor to serve as President of the
Immunotoxicology Specialty Section over the 2014-2015 term, and to workwith a wonderful group of officers and members of our section. I have truly
enjoyed this experience and want to thank the Executive Committee
members for their support and great collaboration.
Dr. Danuta Herzyk
President ImTox SS
2014-2015

Summer 2015

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Immunotoxicology Specialty Section

At the same time, the continuation and expansion of many activities undertaken by the new
ITSS Executive Committee led by the current President, Rafael Ponce, is already evident and I
look forward to further participation in the work and life of the ITSS.
Wishing the ITSS a growing success!
Danuta Herzyk

Student & Postdoctoral Report
Submitted by Aimee Hillegas
Hello to all student and postdoctoral members of the ITSS! I hope you are having a great andproductive summer!
I would also like to thank everyone who made it to the big Student/Postdoc mixer
during the 54th SOT meeting in San Diego. For the first time, the Immunotox Specialty Section
hosted a mentoring session for grad student and postdoctoral members prior to the annual
reception. We had a great turnout with ~ 20 students/postdocs who were able to speak withmembers of the ITSS Executive Committee with a wide range of backgrounds (Academia,
Industry, and Government) and learn how these Executive Committee members got started intheir career and what led them to their current positions. If you were able to attend, keep an
eye out for information regarding the 2nd Annual ITSS Specialty Section Mentoring Session to
be held next year at the 55th Annual SOT Meeting in New Orleans!
Also, Congratulations to our Student/Postdoc Award Winners!
Best Presentation by a Postdoctoral Trainee Award
Dr. Imir Metushi for “The Use of Animal Models in Investigating the Mechanism of
Idiosyncratic Drug-Induced Hepatotoxicity”
Best Presentation by a Student AwardFirst Place: Carrie Long, West Virginia University, for “Increased Expression and
Immunoregulatory Potential of MicroRNA 210 in a Murine Model of TDI Sensitization”
Second Place: Alexandra Turley, Michigan State University, for “The Food Additive tBHQ
Inhibits Activation of Primary Human CD4T Cells”
Third Place: Sarah Attreed, New York University, for “Exposure to Produced Water from
“Fracking” Induces Immunotoxicity in Male Mice”
We would also like encourage new students and postdocs to engage actively in
the ITSS. You can do so by volunteering for a committee of your interest. These activities canhelp you connect with fellow immunotoxicologists and give you experience to state on your CV!
SOT and the Continuing Education Committee invite the Immunotox Specialty
Section to register for online continuing education courses offered by CEd-Tox. Currently there
are approximately 40 online courses available for viewing:
http://www.toxicology.org/education/ce/onlineCourses.asp. A few of these courses may be of
special interest to Immunotoxicology Specialty Section members.
Summer 2015

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New World of Cancer Immunotherapy: Challenges in Bench to Bedside Translation(2015)
Overview and Application of the WHO-IPCS Harmonized Guidance for Immunotoxicity
Risk Assessment for Chemicals (2012)
Drug Hypersensitivity Reactions: Risk Assessment and Management (2011)
Comparative Biology of the Lung (2010)

Cheryl Rockwell
Haley Neff-LaFord
Aimee Hillegas
M. Firoze Khan
Jessica Lynch

L. Peyton Myers
Berran Yucesoy
Gary Burleson
Rafael Ponce
Peyton Myers

M. Firoze Khan
Saurabh Chatterjee
Berran Yucesoy

Marc Pallardy
Rochelle Mikkelsen
Susan McKarns

Ashwini Phadnis

Kristen Mitchell

Jiajun Zhou
Susan McKarns

Haley Neff-LaFord
Kaulini Burra

Cheryl Rockwell
Ratanesh Seth
Susan McKarns
Joe Zagorski
Aimee Hillegas

Ashwini Phadnis
Yu Feng
Bassam Kashgari
Alex Turley

If you would like to join a committee, there are still openings on the Communications &Membership and Education Committees.
Please contact the ITSS Secretary/Treasurer or the Chairperson of the committee(s) if
you are interested in joining.

Summer 2015

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Immunotoxicology Specialty Section

JOB OPPORTUNITIESMPI Research located in Mattawan, MI is currently seeking an enthusiastic immunotoxicologist
to join our Biomarker and Investigative Pathology team. Successful candidate should befamiliar with the design, conduct, analyses, and interpretation of mechanistic studies forunderstanding alterations in innate and adaptive immunity. In addition, the candidate should befamiliar with a broad base of immunotoxicology methods in various laboratory animal species,
including but not limited to flow cytometry, cell proliferation and ligand binding assays.
Candidate will join a team of veterinary pathologists, biomedical scientists, and toxicologists insupport of preclinical drug development studies. Requirements: PhD in Immunology, 1-2 years’
experience in Immunology, Immunotoxicology, or related field. Previous experience intoxicology, biopharmaceutical development or CRO environment is desirable.
If you are interested in this position please visit our website: www.mpiresearch.com/careers
MPI Research is proud to be an Equal Opportunity Employer. Thank you for your interest in
joining the team at MPI Research.
MPI Research is an EO employer – M/F/Veteran/Disability.
Principal Scientist, Immunotoxicologist OR Senior Principal Scientist,
Immunotoxicologist - Non-Clinical Drug Safety - Boehringer Ingelheim, Ridgefield CT
USA
Qualified candidate will be hired at the appropriate level commensurate witheducation/experience.
Description:
This senior laboratory position supports R&D projects to improve safety assessments during
discovery, development and clinical development phases with a specific focus on immunology
and immunotoxicology. The incumbent develops and communicates immunotoxicology
strategy and applies accepted approaches and/or develops novel immunology approaches toachieve project goals. This includes prioritization of projects and supervision of researchscientists assigned to projects.
Duties & Responsibilities:
Assumes leadership role as primary immunotoxicology subject matter expert to crossfunctional and cross-therapeutic area R&D projects and contributes to overall program goals
Directs and supervises junior scientific staff in the conduct of established immunology or
immunotoxicology experiments (in vitro/in vivo) in support of small molecules and biologics.
Lead in proposing and implementing new experimental designs and methodologies tounderstand immunotoxicity mechanisms and risks (i.e. immune stimulation/suppression).

Summer 2015

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Immunotoxicology Specialty SectionPrincipal Scientist, Immunotoxicologist Requirements
PhD, DVM degree or equivalent with 5+ years of relevant experience in immunology or
immunotoxicology
Senior Principal Scientist, Immunotoxicologist Requirements:
PhD, DVM degree or equivalent with 7+ years of relevant experience in immunology or
immunotoxicology in addition to experience in lab management
Scientist IV, Cellular Immunologist – Boehringer Ingelheim, Ridgefield CT USA
Job Description
Description:
Boehringer Ingelheim’s nonclinical drug safety is seeking a talented and motivated seniorlevel Cellular Immunologist who will provide comprehensive scientific and technicalexpertise in cellular immunology. This position requires strong expertise in flow cytometry
applications with experience in cell imaging techniques a desired plus. The successful
candidate will be responsible for the development, qualification and execution of high value,
fit-for-purpose cell-based immunoassays to support Boehringer-Ingelheim’s biologic andsmall molecule candidates in development. The candidate will have a critical role in thedevelopment and implementation of established and novel flow cytometry assays, data
analysis and generation of technical reports. Candidate will also interface with contract labs
for outsourced method transfer and data oversight and review. Candidate must have provenexperience in the delivery of flow cytometry-based assays for use in preclinical studies, andpossess knowledge and understanding of cellular imaging techniques, to enable achieving
project timelines and milestones.
Requirements:
Bachelor’s degree with 10+ years experience or Master’s degree with 6+ years experiencein a relevant scientific discipline such as Immunology, Cell Biology or Biochemistry withpharmaceutical or biotech experience.
Demonstrates experience in flow cytometry operation, maintenance, assay development
and optimization, data analysis and interpretation.
Knowledge in the development, characterization, and implementation of cellularimmunoassays strongly desired.
Contact:
Haley Jaroski
Talent Acquisition Recruiter for Science
Cielo Partner on behalf of Boehringer Ingelheim
215-630-9746
haley.jaroski.ext@boehringer-ingelheim.com

Summer 20156

If you are aware of a job
opening in the specific area of
Immunotoxicology that you
would like to see posted here,
please email the details to
Ashwini Phadnis-Moghe atphadnisa@msu.edu.

Immunotoxicology Specialty Section

2015 Awards Committee Report
Submitted by Dr. Jamie DeWitt
Chair, Awards Committee
2015 Awards Cycle (current chair of Awards Committee: Dr. Cheryl Rockwell)
Each awards cycle, the Awards Committee receives a high number of excellent nominations.
A high number of nominations indicates that not only do we have members who are doing
amazing work, but that we have members who are willing to nominate their students, postdocs, and colleagues. However, it can be challenging for the members of the awardscommittee to rank the various nominees and determine the award recipients. Althoughscoring criteria are clear for all of the awards so that each member of the awards committee
evaluates the strengths and weaknesses appropriately, they may each value strengths andweaknesses slightly differently. Most of the time, these small differences in valuation areminimized by averages, but occasionally, final ranks must be confirmed by additional scoring
techniques. The sum total of points given by each awards committee member as well as theaverage relative ranking of each nominee by awards committee members can help the chairof the awards committee determine if the average is fair and equitable to all nominees,
especially for scores that have large standard deviations or that are separated by very few
points. The update to the Awards Committee Best Practices document drafted by Peyton
Myers and the 2014-2015 Awards Committee includes a scoring template with thesesuggested scoring approaches. In cases where scores are extremely close, tied, or highly
disparate, members of the Awards Committee schedule a conference call to reachconsensus. In the years that I have served on the Awards Committee, scores are usually inagreement for the highest and lowest scoring nominations and discussion is needed to reachagreement for third place awardees. All members of the Awards Committee understand how
precious these awards are for nominees and do their absolute best to ensure fairness andequity in the process. So please, keep the Awards Committee busy and send in thosenominations when you see the call for awards this winter!
Recognizing the scientific contributions of students, postdoctoral trainees, and colleagues is
one of the highlights of the ITSS reception at the Annual Meeting. At this year’s meeting we
presented ten awards. The following two pages list the different award winners and ourcolleagues who have made significant contributions to the field of immunotoxicology

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Immunotoxicology Specialty Section

Vos Award for Lifetime Career Achievement in Immunotoxicology
The first award presented at the ITSS reception is the Vos Award for Lifetime Career
Achievement in Immunotoxicology. This award is presented to an individual in recognition ofcareer achievements in advancing the field of immunotoxicology through service, leadership,and scientific contributions. This year’s honoree was Dr. David Lawrence from New YorkState Department of Health’s Wadsworth Center.

Dr. David Lawrence, New York State Department of Health Wadsworth
CenterOutstanding Senior Immunotoxicologist Award

Dr. Kenneth Hastings, Hastings
Toxicology Consulting
Nominated by Dr. Jack Dean

Summer 20158

Immunotoxicology Specialty Section

2015 Awards (continued)

HESI Immunotoxicology
Young Investigator Travel Award
Dr. Fenna Sillé, University of California
Berkeley

Outstanding Young Investigator Award
Dr. Saurabh Chatterjee
University of South Carolina

Best Presentation by a Postdoctoral
Trainee Award
Dr. Imir Metushi
The Use of Animal Models in
Investigating the Mechanism of
Idiosyncratic Drug-Induced
Hepatotoxicity

Summer 2015

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Immunotoxicology Specialty Section

Immunotoxicology Awards continued
Best Presentation by a Student Awards
First Place
Carrie Long
West Virginia University

Increased Expression and
Immunoregulatory Potential of
MicroRNA 210 in a Murine Model of
TDI Sensitization

Second Place
Alexandra Turley
Michigan State University
The Food Additive tBHQ Inhibits Activationof Primary Human CD4T Cells

Third PlaceSarah Attreed
New York University
Exposure to Produced Water from
“Fracking” Induces Immunotoxicity in Male
Mice

Summer 201510

Immunotoxicology Specialty Section

Immunotoxicology Awards Continued
Best Paper of the Year Award
Genetic Variants in the Major Histocompatibility Complex Class I and Class II
Genes are Associated with Diisocyanate-Induced Asthma.
Journal of Occupational and Environmental Medicine, 2014, 56:382-387.
Authors: Berran Yucesoy, Victor J. Johnson, Zana L. Lummus, Michael L.
Kashon, Marepalli Rao, Hansen Bannerman-Thompson, Bonnie Frye, Wei Wang,
Denyse Gautrin, André Cartier, Louis-Philippe Boulet, Joaquin Sastre, Santiago
Quirce, Susan Tarlo, Dori Germolec, Michael I. Luster, and David I. BernsteinNews and Noteworthy•

Dr.
MichaelPollardreceived
the
ViCTER(Virtual
ConsortiumforTranslational/Transdisciplinary Environmental Research) award from NIEHS that will help
establish a virtual consortium of investigators from Scripps, University of Montana Center
for Environmental Health Sciences and University of Florida. For more about this award
please see the link- https://www.scripps.edu/news/press/2015/20150709pollard.html•

Dr. Rathanesh Seth, a postdoctoral researcher in Dr. Saurabh Chatterjee’s laboratory at
the University of South Carolina received the Association of Scientists of Indian Origin(ASIO)-SIG best postdoctoral presentation abstract Award at the SOT Annual Meeting•

Dr. Saurabh Chatterjee was elected Councilor of ASIO-SIG (Term May 2015-April 2016).

Summer 201511

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Compiled by Haley Neff-LaFord. Anytime you have a new fully-published or electronically-available
article to report, please send the citation to Haley Neff-LaFord at hnlaford@seagen.com

Asthma, Allergy, Autoimmunity & Hypersensitivity
Basketter D, White IR, McFadden JP, and Kimber I. Hexyl cinnamal: consideration of skinsensitizing properties and suitability as a positive control. Cutan Ocul Toxicol 34:227-231, 2015.
Eaton LH, Roberts RA, Kimber I, Dearman RJ, and Metryka A. Skin sensitization induced
Langerhans' cell mobilization: variable requirements for tumour necrosis factor-α.
Immunology 144:139-148, 2015.
Nygaard, UC, Vinje NE, Samuelsen M, Andreassen M, Groeng, EC, Bølling AK, Becher R, Lovik
M and Bodin J. Early life exposure to bisphenol A has modest effects in mouse models of airway
allergy, food allergy and oral tolerance. Food Chem Toxicol 83:17-25, 2015.
Pollard KM. Environment, autoantibodies, and autoimmunity. Front Immunol 6:60, 2015.
Popple A, Williams J, Maxwell G, Gellatly N, Dearman RJ, and Kimber I. The lymphocytetransformation test in allergic contact dermatitis: New opportunities. J Immunotoxicol 6:1-8, 2015.
Yucesoy B, Kaufman KM, Lummus ZL, Weirauch MT, Zhang G, Cartier A, Boulet LP, Sastre J,
Quirce S, Tarlo SM, Cruz MJ, Munoz X, Harley JB, and Bernstein DI. Genome-wide association
study identifies novel loci associated with diisocyanate-induced occupational asthma. Toxicol Sci
146:192-201, 2015.
Yucesoy B, Kashon ML, Johnson VJ, Lummus ZL, Fluharty K, Gautrin D, Cartier A, Boulet LP,
Sastre J, Quirce S, Tarlo SM, Cruz MJ, Munoz X, Luster MI, Bernstein DI: Genetic variants in
TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. J
Immunotoxicol 27:1-8, 2015.

Developmental Immunotoxicology
Abdollahi E, Tavasolian F, Ghasemi N, Mirghanizadeh SA, Azizi M, Ghoryani M and Samadi M.
Association between lower frequency of R381Q variant (rs11209026) in IL-23 receptor gene andincreased risk of recurrent spontaneous abortion (RSA). J Immunotoxicol 12:317-321, 2015.
McFadden JP, Thyssen JP, Basketter DA, Puangpet P, and Kimber I. T helper cell 2 immune
skewing in pregnancy/early life: chemical exposure and the development of atopic disease andallergy. Br J Dermatol 172:584-591, 2015.
Pennings, JLA, Jennen DGJ, Nygaard UC, Namork E, Haug LS, van Loveren H and Granum B.
Cord blood gene expression supports that prenatal exposure to perfluoroalkyl substances causes
depressed immune functionality in early childhood. J Immunotoxicol 12:1-8, 2015.

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Recent Immunotoxicology Publications
General Immunotoxicology
Aligo J, Brosnan K, Walker M, Emmell E, Mikkelsen SR, Burleson GR, Burleson FG, Volk A and
Weinstock D. Murine gammaherpesvirus-68 (MHV-68) is not horizontally transmitted amonglaboratory mice by cage contact. J Immunotoxicol 12:330-341, 2015.
Andreassen M, Bøhn T, Wikmark OG, Van den Berg J, Løvik M, Traavik T, and Nygaard UC.
Cry1Ab protein from Bacillus thuringiensis and MON810 cry1ab-transgenic maize exerts no
adjuvant effect after airway exposure. Scand J Immunol 81:192-200, 2015
Bodin J, Bølling, AK, Wendt A, Eliasson L, Becher R, Kuper F, Løvik M, and Nygaard UC.
Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 developmentin NOD mice. Tox Report 2:99-110, 2015.
Bodin J, Stene LC and Nygaard UC. Can exposure to environmental chemicals increase the riskof diabetes type 1 development? Biomed Res Int 2015 doi:10.1155/2015/208947.
Bonifas J, and Blömeke B. N-acetylation of aromatic amines: implication for skin and immune
cells. Front Biosci (Elite Ed) 7:267-81, 2015.
Chatterjee S and Das S. P2X7 receptor as a key player in oxidative stress-driven cell fate innonalcoholic steatohepatitis. Oxid Med Cell Longev doi: 10.1155/2015/172493, 2015.
Corsini E, Galbiati V, Pinto A, Davin A, Polito L, Guaita A, and Racchi M. Immunostimulatory
effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors.
Oncotarget 6:6524-34, 2015.

DeBord DG, Burgoon L, Edwards S, Haber LT, Kanitz H, Kuempel E, Thomas RS, and Yucesoy
B. Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting, J
Occup Environ Hyg PMID: 6132979, epub ahead of print, 2015.
Englezou PC, Rothwell SW, Ainscough JS, Brough D, Landsiedel R, Verkhratsky A, Kimber I, andDearman RJ. P2X7R activation drives distinct IL-1 responses in dendritic cells compared tomacrophages. Cytokine 74:293-304, 2015.
El-Sisi A, Sokar SS, Salem TA and Abu Risha SE. PPARγ-dependent anti-tumor andimmunomodulatory actions of pioglitazone. J Immunotoxicol 12:308-316, 2015.

Kaplan BL, Li J, LaPres JJ, Pruett SB, and Karmaus PW. Contributions of nonhematopoietic cells
and mediators to immune responses: implications for immunotoxicology. Toxicol Sci 145:214-32,
2015.
Krutz NL, Hennen J, Korb C, Schellenberger MT, Gerberick GF, and Blömeke B. Activation of theendoperoxide ascaridole modulates its sensitizing capacity. Toxicol Sci doi: 10.1093/toxsci/kfv148,
2015.

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Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
General Immunotoxicology Continued:
Lim JH, Won JH, Ahn KH, Back MJ, Fu Z, Jang JM, Ha HC, Jang YJ and Kim DK. Paraquat
reduces natural killer cell activity via metallothionein induction. J Immunotoxicol 12:342-349,
2015.
Maatoft-Udsen K, Greineisen WE, Aldan JT, Magaoay H, Ligohr C, Shimoda LMN, Sung C andTurner H. Comparative analysis of lipotoxicity induced by endocrine, pharmacological, and innate
immune stimuli in rat basophilic leukemia cells. J Immunotoxicol 12:385-394, 2015.
Mak A and Uetrecht. Immunization with amodiaquine-modified hepatic proteins prevents
amodioquine-induced liver injury. J Immunotoxicol 12:361-367, 2015.
Winans B, Nagari A, Chae M, Post CM, Ko CI, Puga A, Kraus WL, and Lawrence BP. Linking thearyl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced
aberrant antiviral CD8+ T cell responses. J Immunol 194:4446-4457, 2015.

Methods/Models
Ahmed SS, Wang XN, Fielding M, Kerry A, Dickinson I, Munuswamy R, Kimber I, and Dickinson
AM. An in vitro human skin test for assessing sensitization potential. J Appl Toxicol doi:
10.1002/jat.3197, 2015.
Corti D, Galbiati V, Gatti N, Marinovich M, Galli CL, and Corsini E. Optimization of the THP-1
activation assay to detect pharmaceuticals with potential to cause immune mediated drug
reactions. Toxicol In Vitro 29:1339-1349, 2015.
Parker GA, Picut CA, Swanson C, and Toot JD. Histologic features of postnatal development of
immune system organs in the Sprague-Dawley rat. Toxicol Pathol 43:794-815, 2015.
Thorn M, Hudson AW, Kreeger J, Kawabe TT, Bowman CJ and Collinge M. Evaluation of a novel
delayed-type hypersensitivity assay to Candida albicans in adult and neonatal rats. J
Immunotoxicol 12:350-360, 2015.
Zhu X, Cole SH, Kawabata TT, and Whritenour J. Characterization of the draining lymph node
response in the mouse drug allergy model: A model for drug hypersensitivity reactions. J
Immunotoxicol 12:376-384, 2015.
Zimecki M, Artym J, Kocieba M, Obminska-Mrukowicz B, Maczynski M, and Ryng S. Immune
function in cyclophosphamide-treated mice is restored by the T-cell-tropic isoxazole derivative R13. J Immunotoxicol 12: 322-329, 2015.

Reviews/Books/Commentaries
Burden N, Mahony C, Müller BP, Terry C, Westmoreland C, and Kimber I. Aligning the 3Rs withnew paradigms in the safety assessment of chemicals. Toxicology 330:62-66, 2015.

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Recent Immunotoxicology Publications
Reviews/Books/Commentaries Continued
Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MT, Hutchinson TH, Kimber I,
and Whelan M. Adverse Outcome Pathways can drive non-animal approaches for safetyassessment. J Appl Toxicol 35:971-975, 2015.
Cochrane SA, Arts JH, Ehnes C, Hindle S, Hollnagel HM, Poole A, Suto H, and Kimber I.
Thresholds in chemical respiratory sensitisation. Toxicology 333:179-94, 2015.
Coico R and Sunshine G. Immunology: A short course. 7th Ed. Wiley Blackwell, 2015.
Goodson WH 3rd, et al.. Assessing the carcinogenic potential of low-dose exposures to chemical
mixtures in the environment: the challenge ahead. Carcinogenesis 36 Suppl 1:S254-96, 2015.
Kaplan BLF, Li J, LaPres JJ, Pruett SB and Karmaus PWF. Contributions of nonhematopoietic
cells and mediators to immune responses: Implications for immunotoxicology. Toxicol Sci
145:214-232, 2015.
Kravchenko J, Corsini E, Williams MA, Decker W, Manjili MH, Otsuki T, Singh N, Al-Mulla F, AlTemaimi R, Amedei A, Colacci AM, Vaccari M, Mondello C, Scovassi AI, Raju J, Hamid RA,
Memeo L, Forte S, Roy R, Woodrick J, Salem HK, Ryan EP, Brown DG, Bisson WH, Lowe L, andLyerly HK. Chemical compounds from anthropogenic environment and immune evasion
mechanisms: potential interactions. Carcinogenesis 36 Suppl 1:S111-27, 2015.
Sanchez Rodriguez LH, Florez-Vargas O, Rodriguez-Villamizar LA, Vargas Fiallo Y, Stashenko
EE and Ramirez G. Lack of autoantibody induction by mercury exposure in artisanal gold minesettings in Colombia: Findings and a review of the epidemiology literature. J Immunotoxicol
12:368-375, 2015.
Verhoeckx KC, Vissers YM, Baumert JL, Faludi R, Feys M, Flanagan S, Herouet-Guicheney C,
Holzhauser T, Shimojo R, van der Bolt N, Wichers H, and Kimber I. Food processing andallergenicity. Food Chem Toxicol 80:223-40, 2015.

SAVE THE DATE!

Abstract Submission: October 7, 2015
Award Nominations: October 9, 2015

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Immunotoxicology Specialty Section