The 6th Annual Meeting of JSIT
1999.9.20-21.
Gonryo Memorial Hall, Tohoku University School of Medicine （Sendai）
President: Hiroshi NAGURA (Tohoku University, Graduate School of Medicine)Special Lecture <1>

The role of the cytochrome
P450 and steroid
J.I. Mason
dehydrogenase gene families insteroid metabolism and action

Department of
Reproductive &DevelopmentalSciences(ClinicalBiochemistry),
University of Edinburgh,
Royal Infirmary ofEdinburgh, Scotland

Special Lecture <2>
From Endocrinilogy toIntracrinology

K. Sasano

Dept. of Pathology.
Tohoku University

Symposium
Prevalence of the Th1/Th2
paradigm inimmunotoxicological research

M. Ohsawa

Dept. ofEnvironmentalToxicology, Faculty ofPharmaceuticalSciences, Teikyo
University

Molecular mechanism ofcytokine gene expression inTh1and Th2Y. Naito

Department ofAnesthesia, Kobe City
General Hospital

T. Kosaka,K. Maita

The Institute ofEnvironmental
Toxicology

Intracellular detection of Th1and Th2 lymphocytes andTh1/Th2 cell balance in mice

Modulation of Th1/Th2 balance
and autoimmune disease byS. Yoshino
environmental factors

Dept. of Microbiology,
Saga Medical School

Dioxin and Th1/Th2 balance

Environmental health
Sciences Division,
National Institute forEnvironmental Studies

K. Nohara,H. Fujimaki

WorkshopAn overview of the methods forskin sensitization tests inY. Kanazawa,K. Kojima
Guinea pigs

Hatano ResearchInstitute, Food and Drug
Safety Center

Murine local lymph node assay

M. Hatao

The State of the Art
Shiseido Basic ResearchCenter

N. Tsutsui

Toxicology Laboratory,
Yokohama ResearchCenter, Mitsubishi
Chemical Corporation

Predectivity of the current
antigenicity study

Investigations of mouse
popliteal lymph node assay as
an allergenicity test

T. Aida,K. Muramatsu,T.

Laboratory Animal
Science and Toxicology

Kimura,K. ShinkaiLaboratories, SankyoCo., Ltd.

The detection ofprimary andToxicology Laboratory,

secondary responses and flow

A. Suda,Y. Iwaki,M.

Pharmaceutical Research

cytometric analysis in popliteal

KimuraLaboratories, Taisho

lymph node assay

Pharmaceutical Co., Ltd.

General Presentation
A study of the exacerbating
model (hyperirritability model)
to the irritant chemicals by

Shiseido Life Sciense
T. Hariya,M. Shibata,H.
Ichikawa

Research Center, Skin
Biology ResearchstressLaboratories

Cytokine production from mast
R. Teshima,J. Onose,H.
cells by ER Ca2+-ATPase
Okunuki,J. Sawadainhibitors

Dev. of Biochemistry andImmunochemistry,
National Institute ofHealth Sciences

The effect of cisplatin and 5fluorouracil to hematopoietic
progenitor cells in mouse bonemarrow

H. Oka,Y. Kouchi,Y.
Maeda,A.Ohuchida

Drug Safety ResearchLaboratory, Taiho
Pharmaceutical Co., Ltd.

Effests of methoxychlor andDDT on the thymocyte subsets
in immature rats

Y. Takeuchi,T. Kosaka,K.
Hayashi,H. Aoyama,K.
Maita,S. Teramoto,T.
HaradaToxicology Divisions
Ⅰand Ⅱ, The Instituteof Environmental
Toxicology

Mutational screening of Fas andT. Otsuki(1), A.
Fas ligand coding regions inTomokuni(1), F.
peripheral blood mononuclear
Hyodoh(1), A.
cells derived from silicosis
Ueki(1),M. Kusaka(2)patients
Morphologic characterization ofhost immune reactions against H. Ohtani, Y. Naito,
cancer cells in Ebstein-Barr
Saiki, K. Saito, H.
virus-associated gastric cancer Nagura
and colon cancer(1)Dept. of Hygiene,
Kawasaki Med. Sch.
(2)Dept. of Intern. Med.,
Kusaka Hosp.

Y.

A short term guinea pig test as
M. Yanagi,M. Hoya,M.
an alternativeto conventional
Mori,Y. Katsumura
guinea pig maximization test

Department ofPathology, Tohoku
University School ofMedicine
Life science research
center, Shiseido Co., Ltd.

Occupational allergy in doctors

K. Sato,Y. Kusaka,Q.
Zhang,X. Zhu,Y. Deguchi

Dept. of Environmental
Health, Fukui Medical
University

Effects of N-[1-(5-deoxy-betaD-ribofuranosyl)-5-fluoro-1, 2dihydro-2-oxo-4-pyrimidinyl]n-pentyl carbamate (Ro 091978) on humoral and cellularimmunity in mice

T. Inoue,T. Isobe,A.
Kubota,I. Horii

Dept. of Preclinical
Science, Nippon Roche
Research Center

D-Penicillamine-induced lupus
in the rat

M. Nagata,M. Hino,K.
Nakamura

Developmental ResearchLaboratories, Shionogi &Co., Ltd.

N. Sato(1),T.

Kawanabe(1),Tuchiya(1),Immunosuppressive effect andnephrotoxicity of aristolochic
acids in inbred miceR.

D.

Communication, Faculty

Takahashi(1),T.

of Pharmaceutical

Mukouyama(1),Chen(1),(1)Drug Information andS. M.

A. Turuoka(1),Sciences, Chiba
University(2)Central

S. Yamagata(1), M.
Mochizuki(1), S.

Reseach Laboratory,
Kotaro PharmaceuticalUeda(1),

Co., LTD.

M. Yoshida(2),S. Kondo(2)Comparative pro-inflammatory

Dept. of Environmental

effects of mercuric chloride on

X. Zhu,Q. Zhang,K.

Health, School ofalveolar macrophages fromSato,Y. Kusaka

Medicine,Fukui Medical

different strains of rat in vitro

University
Dept. of Environmental

The endocrine disruptive
effects of mercury: a review

X. Zhu,K. Sato,Y.
Kusaka,Q. Zhang

Health, School ofMedicine,Fukui MedicalUniversity(1)Dept. of Hygiene &Preventive Medicine,
Faculty of Health
Sciences, The Universityof Shizuoka(2)Research Reactor
Institute, Kyoto
University

Brain function lesion byimmunotoxic agent-Organotin-

Y. Arakawa(1), H.
Suzuki(1), Y. Ohtani(1),T. Takeuchi(2), Y.
Nakano(2)Dexamethasone protects acutecadmium-induced liver injury,
but exacerbates the kidney
injury in rabbits

H. Horiguchi(1)(2), E.
(1)Fukushima MedicalOguma(1), M. Satoh(1),University, (2)Jichi
F. Kayama(2), M.
Medical School
Fukushima(1)The effect of stress caused byattending a meeting on IgA,IgG, and cortisol in saliva

S. Tsujita,S. Fukuda,K.
Morimoto

K. Sakabe(1),Effect of endocrine disruptors
on immune and neuraldevelopment, with specialreference to the expression of14-3-3 protein kinase
modulators

Dept. of Social andEnvironmental Medicine,
Osaka University
Graduate School ofMedicine

T.

Yoshida(1), H.
Aikawa(1), O.
Tanaka(1), M.
Sekiguchi(1), S.
Izumi(1), Y.
Osamura(1), F.
Kayama(2), S.

(1)Tokai University
School of Medicine,(2)Jichi Medical School,(3)Saga Medical School

Yoshino(3)Expression of17βhydroxysteroid dehydrogenase
type2 in humangastrointestinal and liver

T. Sano,H. Sasano

Expression of 17βhydroxysteroid dehydrogenase
type2 anddehydroepiandorosterone
sulfotransferase in humannliver

Dept. of Pathology.
Tohoku University

Tohoku University
T. Narasaka,M. Endo,T.
Suzuki,H. Sasano

School of Medicine,
Department ofPathology

Immunotoxicological effects ofendocrine disrupting chemicals
on the mouse lymphocytes
blastformation and theinvolvement of the estrogen
receptor

Division ofF. Sakazaki,H. Ohki,Y.
Takenaka,H. Ueno,K.
Nakamuro

Study on immunologicalmethods available for theevaluation of human healtheffects

Environmental Health,
Faculty of
PharmaceuticalSciences, Setsunan
University(1)Tokai University

T. Yoshida,(1),Osawa(2)M.

School of Medicine,(2)Teikyo University
School of Pharmacy