Immunotoxicology Specialty
Section Newsletter
Outgoing President’s Message
2014-2015
Executive Committee
President
Dr. Danuta Herzyk
Vice President
Dr. Rafael Ponce
Vice President-ElectViP
id t El t
Dr. Peyton Myers
Secretary-Treasurer
Dr. Haley Neff-LaFord
Past President
Dr. Gary Burleson
Senior Councilor
Dr. Jamie DeWitt
Junior Councilor
Dr. Cheryl Rockwell
Postdoc Representative
Dr Ashwini Phadnis-Moghe
Dr.
Student Representative
Aimee Hillegas

The ImTox SS Newsletter ispublished 3 times/year (Summer,
Fall, and Winter). If you would like toshare an item of interest withmembers of the ImTox SS, please
send it to the Communications
Committee Chair. All comments on,or suggestions to, the newsletter are
welcome.

Ashwini Phadnis-Moghephadnisa@msu.edu

August 2014

Submitted by Gary R. Burleson, PhD.
It seems like only yesterday I was
writing the Incoming President’s Message for
the Immunotoxicology Specialty Section (ITSS)
but, while time flew by quite quickly, it has been
an exciting year for our Specialty Section.
I was fortunate to have an excellent, dedicated,and proactive Executive Committee consistingof: Past President Greg Ladics, Vice President
Dr. Gary Burleson
Danuta Herzyk, Vice-President-Elect Rafael
President, ImTox SS
Ponce, Secretary/Treasurer Haley Neff-LaFord,
2013-2014
Senior Councilor Peyton Myers, Junior Councilor Jamie DeWitt,
Postdoctoral Representative Teri Girtsman followed by Kinta Serve,
andd Student
St d t RepresentativeRt ti Kinta
Ki t ServeSf llfollowedd byb AimeeAi
Hill
Hillegas.
We were supported by our Extended Executive Committee Chairs:
Judy Zelikoff (Education), George DeGeorge (Membership), Ashwini
Phadnis (Communications), Mitch Cohen (International Exchange),
and Peter Thomas (Regulatory). We are also indebted to Raul
Suarez (SOT Liaison to Awards Committee, Specialty Sections, andSpecial Interest Groups) for the prompt,
prompt courteous,courteous and professional
advice provided cheerfully to our many questions and requests forassistance. We inherited a strong and vibrant Specialty Sectionthat is expected to have continued growth because of the important
health issues resulting from exposure to agents that are
immunotoxic. Our Specialty Section consists of 374 members, is inth topthet 5 off allll 27 Specialty
S
i lt Sections
S ti(2013 2014 SOT Membership(2013-2014
M b hi
Directory),
Outgoing President’s Message………….………………………….…1
President’s Message………………………………………………….…3
Student Postdoctoral Report ………………………………....….…...4
Announcements................................................................................5AAwardsd CommitteeC
itt Report…………..………………………………....6
Rt
6
ImTox SS Reception Pictures…………………………………….……12
ImTox SS Committee Lists……………...……………………………..13
Recent Immunotoxicology Publications…………………………...14
1

Immunotoxicology Specialty Sectionand reflects the tremendous interest in immunotoxicology as an important component in thesafety assessment of chemicals, biologics and new chemical entities.
The Executive Committee decided to not have stated goals at the beginning of
our term in 2013,2013 but rather to develop issues of interest and goals at our monthly
teleconference calls. This flexible approach worked well to promptly address current issues.
We also worked diligently toward defining who we are, where we’re going, and how todetermine the best way to get there.
As an Executive Committee we described and discussed the importance of
education and appropriate training of immunotoxicologists. The rapid growth of the field of
immunotoxicology reflects those interested in the field for a variety of reasons, e.g.,knowledge of a specialized discipline important for a thorough safety evaluation. Properly
trained immunotoxicologists require both educational and laboratory training in order toproperly design, conduct, and interpret studies.
In order to recognize outstanding
immunotoxicologists, we established a new award entitled: Outstanding Senior
Immunotoxicologist Award to recognize an immunotoxicologist for his/her significant
contributions to the field of immunotoxicology. This award filled the career gap between the
Outstanding Young Investigator Award to a promising young investigator who has had an
impact on the field of immunotoxicology, and the Vos Lifetime Career Achievement Award thatrecognizes a lifetime of career achievement in immunotoxicology. These 3 awards now
recognize excellence at all stages of one’s career. The winners of these ITSS prestigious
awards will be described in detail in subsequent sections of the newsletter, but I want to takethe opportunity to congratulate this year’s award winners: Dr. Robert Luebke, for the Vos
Lif tiLifetime
C
CareerA hi
Achievementt Award,A
d Dr.
D Norbert
N b t Kaminski
K i ki forf
th OutstandingtheO t t diS i
SeniorImmunotoxicologist Award, and Dr. Ashlyn E. Bassiri and Dr. Cheryl E. Rockwell who shared
the Outstanding Young Investigator Award.
The 2014 national SOT meeting in Phoenix, Arizona was a success. Danuta
Herzyk, Vice President of the ITSS, served as the Program Chair for the 2014 meeting andthe committee’s efforts were rewarded by many ITSS submissions and acceptances for the
Phoenix meeting.
meeting
The Executive Committee and the Extended Executive Committee
meeting of the ITSS was held during the 2014 national SOT meeting. As President, it was
my privilege and pleasure to introduce the new officers: incoming VP-Elect Peyton Myers,
incoming Senior Councilor Jamie DeWitt, and incoming Junior Councilor Cheryl Rockwell,and Guests ITSS Past President Leigh Ann Burns Naas, and Kazuichi Nakamura. The
financial report was presented by Treasurer Haley Neff-LaFord and discussion focused on themonetary award for the five types of awards (Student Awards with 1st place $500, 2nd place$300, and 3rd place $200), the Postdoctoral Award of $500, and the HESI Young
Immunotoxicology Travel Award to cover the cost of travel. The monetary awards, in addition
to the prestige of the award itself, should assure continued excellence in submissions fromstudents, our future generation of immunotoxicologists.
The ITSS and the JSIT (Japanese Society of Immunotoxicology) have a richhistory of collaboration for pursuit of excellence in immunotoxicology. The ITSS invited
Kazuichi Nakamura, DVM, PhD as a featured speaker at the ITSS reception to discuss thecontinuing and important collaboration between the ITSS and JSIT.

August 20142

Immunotoxicology Specialty Section

Rafael Ponce, the current ITSS Vice President, led the Program Committee for the 2015
meeting in San Diego, California. Thanks to the committee’s efforts, there were a large
number of submissions and we can again be assured of a strong Immunotoxicology presence
for the 2015 meeting.
It was with great pride, honor and trepidation that I began my term as Presidentof the ITSS – following many who have held this office with honor and dedication. It is with
thanks to those on the Executive Committee, the Extended Executive Committee, and ouractive membership that I believe we have had an impact as we go forward.
Gary R.
G
R Burleson
B l
Past President, ImTox SS (2013-2014)

Incoming President’s Message
Submitted by Danuta Herzyk, Ph.D
It is a great honor for me to receive the baton to continue thepath as President of the Immunotoxicology Specialty Section that is
approaching its 30th anniversary of existence. I hope to carry on the great
work and dedication of all Past Presidents, from our founder, Dr. Jack Dean
Dr. Danuta Herzyk(1985-86), to my immediate predecessor, Dr. Gary Burleson. I would like to
President ImTox SS
thank Gary for his leadership in the past year and thank all ITSS members
2014-2015
for yyour support
pp and contribution to the section.
The driving force in the ITSS is a volunteer Executive Committee that is a mix ofseasoned members ensuring continuity and new members bringing in “fresh breath”.
Congratulations to our newly elected officers: Peyton Myers (Vice-President Elect) and Cheryl
Rockwell (Junior Councilor). I look forward to working with our newly elected and current officersof the Executive Committee: Rafael Ponce (Vice-President and Chair of the Program
Committee),), Haleyy Neff-LaFord ((Secretary-Treasurer),y), Jamie DeWitt ((Senior Councilor)) andAimee Hilegas (Student Representative). My sincere thanks go to Kinta Serve for her
contributions as the Postdoctoral Representative and I wish her good luck in her new career. At
the same time, a warm welcome is extended to our newly elected Postdoctoral Representative Ashwini Phadnis! Ashwini holds a Postdoctoral Research Associate position at Dr. Norbert
Kaminski’s Laboratory at Michigan State University. Ashwini is not a stranger to the ITSS as she
has been a very active graduate student member of the SOT and the communication liaison
between the SOT and the ITSS in recent years. Congratulations and good luck to Ashwini inher new role! The new term of the ITSS started in the spring with great intensity for the Program
Committee that is in charge of reviewing all ITSS-sponsored program proposals for the 2015
Annual SOT meeting. Rafael and the members of the Program Committee have completed theirdiligent work on these proposals and we very much appreciate their effort.
As mentioned, the ITSS is approaching its 30-year anniversary in 2015. This
milestone
il tshouldh ld stimulate
ti l t us tot reflect
fl t on theth historyhi t
andd alsol tot think
thi k aboutb t theth futuref t
off theth
ITSS. Our group has grown over time and our members’ involvement has been crucial in the
success and positive influence the ITSS has demonstrated in both the immunotoxicology
community and the broader SOT forum. I would also like to encourage the ITSS members toAugust 20143

Immunotoxicology Specialty Section

share their thoughts and reflections on our 30 years of service to Immunotoxicology in future
Newsletter issues.
Please send your article submissions to Ashwini Phadnis (phadnisa@msu.edu) andpublications to Haley Neff-LaFord
Neff LaFord (hnlaFord@seagen(hnlaFord@seagen.com),com) who lead the Communications
Committee.
Let us make the 2014/2015 ITSS term very special and exciting.
Danuta Herzyk, PhD
President, ImTox SS (2014-2015)

Student & Postdoctoral Report
Submitted by Aimee Hillegas
Hello to all student and postdoctoral members of the ImTox SS! I hope you arehaving a great and productive summer! We must say goodbye and a big thank you to our outgoing postdoctoral representative,
representative Kinta Serve,
Serve for a job well done these past two years andwish her best of luck in her future endeavors! At the same time I would like to extend a warm
welcome to the newly elected postdoctoral representative, Ashwini Phadnis. Ashwini is currently
a postdoctoral research associate at Michigan State University.
I would also like to thank everyone who made it to the big Student/Postdoc mixer
during the 53rd SOT meeting in Phoenix. We had a wonderful turn out and lots of fun.
Additionally,y, we had an ImmunoTox SS mixer at the District American Kitchen jjust pprior to theannual ImmunoTox reception and award ceremony. Although the turnout was small, we had agreat time and some good discussion of ways for students and postdocs to get more involved in
the specialty section.
SOT and the Continuing Education Committee invite the Immunotox Specialty
Section to register for online continuing education courses offered by CEd-Tox. Currently there
are 27 online courses available for viewing. http://www.toxicology.org/AI/ce/ce_video/index.asp.
A few of these courses may be of special interest to Immunotoxicology Specialty Section
members:
Comparative Biology of the Lung (2010)
Drug Hypersensitivity Reactions: Risk Assessment and Management (2011)
Overview and Application of the WHO-IPCS Harmonized Guidance for Immunotoxicity
Risk Assessment for Chemicals (2012)
These courses are a great way to expand professional development or stay current in the fieldof toxicology. Many additional courses are available from the Annual Meetings from 2009-2012.
Registration provides 30-day unlimited access to complete the course at any time or location.
Course attendance certification letters are available upon completion of the course. Graduate
Student and Postdoc members of SOT receive free access to courses! Contact Email:David Rossé (davidr@toxicology.org)
As always,
always I would like to thank you for this opportunity to serve you.
you If you would
like to participate in organizing/planning any events or if you have any questions, please feel
free to contact me at ahillegas@mail.usp.edu. I would love to have everyone’s involvement.

August 2014

4

Immunotoxicology Specialty Section

Announcements!

Background Information: Epidemiology data indicate that significantly altered immunity(immunosuppression or chronic inflammation) increases the risk of cancer. Oncogenic
viruses are implicated in some but not all instances of increased risk associated withimmunosuppression. There is also a dynamic relationship between immunity and tumor
development, where immune responses can shape both pro-tumorigenic and antitumorigenic microenvironments and influence tumor progression. The current nonclinicalassessment of cancer risk associated with immunomodulatory therapies conducted in thepharmaceutical and biotechnology industry and by regulators includes target-related
gy studies,, certain immune status/function assessments (case(information,, standard toxicology
by-case), and, when applicable, rodent carcinogenicity studies, even though it is recognizedthat rodent carcinogenicity studies are not necessarily predictive of the cancer risk
associated with immunomodulation. In addition, in many cases rodents are notpharmacologically relevant species for biologics, and such rodent carcinogenicity studies
cannot be conducted. The overall goal of this workshop is to provide clarity on what can bedone to better inform risk of cancer with immunomodulatory therapies.
Objectives of the workshop:
Review current knowledge on human cancer risk associated with altered immunity
and the current understanding of the associated mechanisms driving cancer development
Review the available models, tools and approaches available to conduct appropriate
weight-of-evidence based assessments of cancer risk associated with new
immunomodulatory therapies.
therapies
Identify knowledge gaps / opportunities for research efforts to help improve ability to
conduct appropriate assessments of cancer risk associated with new immunomodulatory
therapies
Define the points to consider for building an appropriate weight-of-evidence based
assessment of cancer risk associated with new immunomodulatory therapies
For additional information or questions, please contact Dr. Connie Chen
(cchen@hesiglobal.org).

August 2014

5

Immunotoxicology Specialty Section

JOB OPPORTUNITIESThe National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory
Division (HELD), located in Morgantown, West Virginia has an opening for a postdoctoral fellow intheandBranch.
off theth AllergyAlld ClinicalCli i l Immunology
I
l
B
h The
Th focusfth labl b isi tot identify
id tif occupational
ti
l and
d
environmental chemical hazards by evaluating immune function using murine models. The
candidate should have a PhD in immunology or a related field. A background in toxicology ispreferred but not mandatory. Excellent graduate training, good publication record, experience within vivo mouse models is desirable. Salary range starts at $57,982.
CDC-NIOSH
CDC
NIOSH is an affirmative action/equal opportunity employer
employer.
Interested applicants should email their curriculum vitae, a statement of current and future researchinterests and why you are interested in our research, and complete contact information of threereferences to Sanderson4@cdc.gov.
If you are aware of a job
openingp
g in the specificparea of
Immunotoxicology that you
would like to see posted here,
please email the details to
Ashwini Phadnis-Moghe atphadnisa@msu.edu.

Stacey Anderson, Ph.D.
Team Leader
Hazard Identification and Immunotoxicology Lab
1095 Willowdale Dr. M/S 4020
Morgantown, WV 26505
Phone (304) 285-6024 Fax (304) 285-6126

2014 Awards Committee Report
Submitted by: L. Peyton Myers, Ph.D.
Congratulations to our many award recipients as well as the nominees for 2014! It
was a great pleasure to Chair the Awards Committee in 2014 and see the depth and scientificbreadth of the many nominees from our ImTox SS.
SS Recognizing our students and colleagues is
an important aspect of our Specialty Section. By taking the time to nominate your colleagues, it
not only provides recognition of their efforts, but it also helps publicize their accomplishments to
the rest of the Society.
ImTox SS Awards Committee was proud to award this year’s winners at thereception during the SOT Annual Meeting in Phoenix, Arizona. We had multiple nominees forg y The submissions were exceptionalp
and the decisions were,, as always,
y , veryy
everyy category.
challenging!
The Awards Committee would like to thank the nominators for taking the time andeffort to support your fellow ImTox SS members by submitting nominations. I would like to thankthe Awards Committee for their efforts to review the packages thoroughly and thoughtfully. I
would also like to thank Jamie DeWitt, who worked tirelessly (and quickly!) and was my righthand during the process. Jamie is your incoming Awards Chair for 2015 and I know she will do astellar job!
Again, congratulations for the Awards Winners!
August 2014

6

Immunotoxicology Specialty Section

2014 Awards (continued)

Recognizing the scientific contributions of students, postdoctoral trainees, and colleagues is
one of the highlights of the ITSS reception at the annual meeting. At this year’s meeting we
presented ten awards, including a new award, The Outstanding Senior Immunotoxicologist
Award. This award was instituted as a way to honor those colleagues who have madesignificant contributions to the field of immunotoxicology and who are at a “mid-point”
mid point in theircareers. The first recipient of this award was Dr. Norbert “Norb” Kaminski, who is a professor
in the Department of Pharmacology and Toxicology at Michigan State University and the
Director of the Center for Integrative Toxicology, also at Michigan State University. Dr.
Kaminski was nominated by a previous graduate student who highlighted Dr. Kaminski’s
many scientific accomplishments and advancements in the field of immunotoxicology. More
importantly, the nominee emphasized Dr. Kaminski’s strong work ethic, “desire to continue topropel the field of immunotoxicology forward” and ability to find the balance between
confidence and humility. It was the honor of the ITSS Awards Committee to present thisaward to Dr. Norb Kaminski.

August 20147

Immunotoxicology Specialty Section

Vos Award for Lifetime Career Achievement in Immunotoxicology
The final award presented at the ITSS reception is the Vos Award for Lifetime Career
Achievement in Immunotoxicology.
Immunotoxicology This award is presented to an individual in recognition ofcareer achievements in advancing the field of immunotoxicology through service, leadership,and scientific contributions. This year’s honoree was Dr. Robert “Bob” Luebke, a Research
Biologist at the U.S. Environmental Protection Agency. Dr. Luebke began his career at the EPA
in 1981 and in the 30+ years at the agency, he has contributed substantially to the field of
immunotoxicology through his work with host resistance models, the study of
immunosuppression in rodent models and its relevance to immunotoxicity testing,testing how theimmune system responds to various toxic agents at different life stages, and the application of
immunotoxicity data to the risk assessment process. Dr. Luebke was nominated by a fourperson team, including a supervisor, a colleague, and two of his past postdoctoral mentees.
The nominators emphasized Dr. Luebke’s critical influence on a number of formative events
crucial to the development of immunotoxicology as a highly respected area of toxicology.
These contributions have included everyy office within the ITSS as well as NIEHS ppanels andworking groups, the World Health Organization, the Organization for Economic Cooperation
and Development, HESI/ILSI, and EPA-level initiatives. Notably, Dr. Luebke has had
productive multidisciplinary collaborations with neurotoxicologists, developmental toxicologists,and statisticians. The breadth and depth of his contributions to the field have are truly
impressive Additionally, even though training is not a standard part of the terms of his
employment with the EPA, he has mentored several postdoctoral trainees and students who
continue to make contributions to the field of immunotoxicology, thus cementing his influenceon future generations. Dr. Bob Luebke has devoted the majority of his professional career todevelopment field of immunotoxicology and the ITSS Awards committee was enormously
pleased to honor him with this award.

August 20148

Immunotoxicology Specialty Section

2013 Awards (continued)
Outstanding Young Investigator Award
Dr. Ashlyn E. Bassiri
Department of Immunologic Toxicology, GlaxoSmithKline

Dr. Cheryl Rockwell
Department of Pharmacology and Toxicology
Michigan State University

Presentation by a Postdoctoral Trainee Award
Dr. Nikki B.
D
B MarshallM h llNational Institute for Occupational Safety & Health
Early immunomodulatory effects of dermal triclosan
exposure in miceAugust 2014

9

Immunotoxicology Specialty Section

Immunotoxicology Awards continued
Best Presentation by a Student AwardFirst Place
Lisbeth A. Boule
University of Rochester Medical Center
DevelopmentalDlt l activation
ti ti off theth AhR enhanceshthe CD4+ T cell response in the influenza virus
infected lung

Second Place
Juyoung Shim
University of Maine
Inorganic Arsenite Suppresses Mast Cell
Degranulation via a Pathway Target Upstream ofCalcium Signaling

Third Place
Joseph W. Zagorski
Michigan State University
Inhibition of IL-2 production by the Nrf2 activator,tBHQ, correlates with inhibition of NFkB activationin activated Jurkat T cells

August 201410

Immunotoxicology Specialty Section

Immunotoxicology Awards Continued

Best Paper of the Year Award
Jennifer L. H. Wheeler, Kyle C. Martin, Emily Resseguie, and B. Paige Lawrence
University of Rochester School of Medicine and Dentistry, Rochester, NY
Differential Consequences of Two Distinct AhR Ligands on Innate and Adaptive
Immune Responses to Influenza A Virus
Toxicological Sciences 137(2):324-334, 2014HESI Immunotoxicology Young Investigator Travel Award
Dr. Edmund O’Brien
Department of Pathology
University of Vermont

August 201411

Immunotoxicology Specialty Section

Pictures from the ImTox reception and poster session – SOT 2014

August 201412

Immunotoxicology Specialty Section

Rafael Ponce (Vice President/Chair)
M. Firoze Khan
N
Narendrad Singh
Si hDavid LawrenceMichael Lynes
Berran Yucesoy
David LehmannPeer Karmaus
Venkatesh Hegde

Jamie DeWitt (Sr. Councilor/Chair)
M. Firoze Khan
Berran Yucesoy
Sarah Blossom
Michael Laiosa
Malvin Stern
Yasumitsu NishimuraPeter Thomas (Chair)
Greg Bannish
David LehmannAndrew Rooney
Narendra Singh

Ashwini Phadnis-Moghe (Chair)
Haley Neff-LaFord
Anand Ravindran

Judith Zelikoff (Chair)David Lawrence
Venkatesh Hegde

George DeGeorge (Chair)

If you would like to join a committee, there are still openings on theRegulatory, Communications, Education and Membership Committees.
Please contact the ImTox SS Secretary-Treasurer or the Chairperson of thecommittee(s) if you are interested in joining.

August 201413

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Compiled by Haley Neff-LaFord. Anytime you have a new fully-published or electronically-available
article to report, please send the citation to Haley Neff-LaFord at hnlaford@seagen.com
Asthma,A
th
All
Allergy, A
Autoimmunityt i
it & H
Hypersensitivity
iti itAlbrekt AS, Johansson H, Börje A, Borrebaeck CAK, Lindstedt M. Differentially regulated pathways in
MUTZ-3 cells stimulated with skin sensitizers. BMC Pharmacol Toxicol 15:5, 2014.
Chapman VL, Zollinger T, Terranova R, Moggs J, Kimber I and Dearman RJ. Chemical allergeninduced perturbations of the mouse lymph node DNA methylome. Toxicol Sci 139:350-361, 2014.
Corsini E, Papale A, Galbiati V, and Roggen E. Safety evaluation of cosmetic ingredients: in vitro
opportunities for the identification of contact allergens. Cosmetics 1:61-74, 2014.
Galbiati V, Papale A, Galli CL, Marinovich M, and Corsini E. Role of ROS and HMGB1 in contact
allergen-induced IL-18 production in human keratinocytes. J Invest Dermatol, 2014. doi:
10.1038/jid.2014.203.
Lefebvre DE, Pearce B, Fine JH, Chomyshyn E, Ross N, Halappanavar S, Tayabali AF, Curran I and
Bondy GS. In vitro enhancement of mouse T helper 2 cell sensitization to ovalbumin allergen bycarbon black nanoparticles. Toxicol Sci 138:322-332, 2014.
Pot LM, Coenraads PJ, Goebel C, and Blömeke B. Assessment of the elicitation response in subjects
weakly sensitized to p-phenylenediamine. Br J Dermatol, 2014. doi: 10.1111/bjd.13142
Ter Burg W, Bouma K, Schakel DJ, Van Wijnhoven SWP, Van Engelen J, Van Loveren H, andEzendam J. Assessment of the risk of respiratory sensitization from fragrance allergens released by air
fresheners. Inhal Toxicol 26:310-318, 2014.
Toomer OT, Ferguson M, Pereira M, Do A, Bigley E, Gaines D and Williams K. Maternal and postnatal
dietary probiotic supplementation enhances splenic regulatory T helper cell population and reduces
ovalbumin allergen-induced hypersensitivity responses in mice
mice. Immunobiol 219:367-376,
219:367-376 2014
2014.
Developmental Immunotoxicology
Ahrenhoerster LS, Tate ER, Lakatos PA, Wang X and Laiosa MD. Developmental exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin attenuates capacity of hematopoetic stem cells to undergo lymphocyte
differentiation. Toxicol Appl Pharmacol 277:172-182, 2014.
B il KA,
BaileyKA Laine
L i JJ, Rager
R
JE S
JE,
Sebastianb ti E
E, Olshan
Ol h A,A SmeesterSt L,
L Brobna
B b Z,Z Styblo
St bl M,
M R
Rubio-Andradebi A d d
M, Garcia-Vargas G and Fry RC. Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci 139:328-337,
2014.
Dietert RR. Macrophages as targets of developmental immunotoxicity (DIT). OA Immunol 18:2(1)2,
2014.

August 201414

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Developmental Immunotoxicology Continued
O’Brien E, Bergin IL, Dolinoy DC, Zaslona Z, Little RJ, Tao Y, Peters-Golden M and Mancuso P.
p
A exposurep
beginninggg before ggestation enhances allergeng sensitization,, but not
Perinatal bisphenol
pulmonary inflammation, in adult mice. J Dev Orig Health Dis 5:121-31, 2014.
General Immunotoxicology
Corsini E, Luebke RW, Germolec DR, and DeWitt JC. Perfluorinated compounds: Emerging POPs withpotential immunotoxicity. Toxicol Lett, 2014. doi: 10.1016/j.toxlet.2014.01.038.
Doedee ACM, Boland G, Pennings JLA, de Klerk A, Berbers GAM, Van der Klis FRM, De Melker HE,
Van Loveren H, and Jandden R. Effects of prophylactic and therapeutic paracetamol treatment during
vaccination on Hepatitis B antibody levels in adults: Two open-label, randomized controlled trials.
PLOS one, 2014. DOI:10 1371/journal.pone.0098175
Hagen MO, Katzenback BA, Islam MDS, El-Din MG and Belosevic M. The analysis of goldfish(Carassius auratus L.) innate immune responses after acute and subchronic exposure to oil sands
process affected water
process-affectedwater. Toxicol Sci 138:59-68,
138:59 68 2014
2014.
Huang YY, Xia MZ, Wang H, Liu XJ, Hu YF, Chen YH, Zhang C and Xu DX. Cadmium selectively
induces MIP-2 and COX-2 through PTEN-mediated Akt activation in RAW264.7 cells. Toxicol Sci
138:310-321, 2014.
Looker C, Luster MI, Calafat AM, Johnson VJ, Burleson GR, Burleson FG and Fletcher T. Influenza
vaccinei response iin adults
d lt exposedd tto perfluorooctanoate
fl
t
t and
d perfluorooctanesulfonate.
fltlft Toxicol
T i l Sci
S i
138:76-88, 2014.
Nayak AP, Hettick JM, Siegel PD, Anderson SE, Long CM, Green BJ and Beezhold DH. Toluene
diisocyanate (TDI) disposition and co-localization of immune cells in hair follicles. Toxicol Sci 140:327337, 2014.
Osman A, and Van Loveren H. Matrin 3 co-immunoprecipitates with the heat shock proteins glucoseregulated protein 78 (GRP78), GRP75 and glutathione S transferase π-isoform (GSTπ2) in thymoma
cells. Biochimie 101:208-214, 2014.
Schmeits PCJ, Katika MR, Peijnenburg ACM, van Loveren H, and Hendriksen PJM. DON shares asimilar mode of action as the ribotoxic stress inducer anisomycin while TBTO shares ER stresspatterns with the ER stress inducer thapsigargin based on comparative gene expression profiling in
Jurkat T cells. Toxicol Lett 224:395-406, 2014.
Schmeits PCJ, Van Kol S, Van Loveren H, Peijnenburg ACM, and Hendriksen PJM. The effects oftributyltin oxide and deoxynivalenol on the transcriptome of the mouse thymoma cell line EL-4. Toxicol
Res 2014. DOI: 10.1039/c3tx50100k
S ao J, Berger
Shao
e ge LF,, Hendriksene d se PJM,
J , Peijnenburg
e j e bu g ACM,
C , vana Lovereno e e H,, aandd Volgero ge OOL.
Transcriptome-based functional classifieres for direct immunotoxicity. Arch Toxicol 88:673-689, 2014.

August 201415

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
General Immunotoxicology Continued
Spiering R, Wagenaar-Hilbers J, Huijgen V, van der Zee R, van Kooten PJS, van Eden W and Broere
F. Membrane-bound metallothionein 1 of murine dendritic cells promotes the expansion of regulatory T
cellsces in vitro.
o Toxicol
o co ScSci 138:69-75,
38 69 5, 2014.
0
Tadagavadi R, Daginakatte G, Ramesh G, and Reeves WB. Dendritic cells in drug-induced toxicity.
Clin Exp Pharmacol 4:150
Vandebriel RJ, Tonk ECM, De la Fonteyne LJ, Gremmer E, Verharen HW, Van der Ven L, Van
Loveren H, and De Jong WH. Immunotoxicity of silver nanoparticles in an intravenous 28-day
repeated-dose
repeateddose toxicity study in rats
rats. Particle and Fibre Toxicol 11:1
11:1-21
21, 2014
2014.
Methods/Models
Finco D, Grimaldi C, Fort M, Walker M, Kiessling A, Wolf B, Salcedo T, Faggioni R, Schneider A,
Ibraghimov A, Scesney S, Serna D, Prell R, Stebbings R and Narayanan PK. Cytokine releaseassays: current practices and future directions. Cytokine 66:143-155, 2014.
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Reviews/Books/Commentaries
Kimber I, Dearman RJ, Basketter DA and Boverhof DR. Chemical respiratory allergy: reverse
engineering an adverse outcome pathway. Toxicology 318:32-39, 2014.
Gundert-Remy U, Bernauer U, Blömeke B, Döring B, Fabian E, Goebel C, Hessel S, Jäckh C, Lampen
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SAVE THE DATE!
54th Annual Society of Toxicology Meeting
March 22-26, 2015
San Diego, California
Abstract Submission: October 7, 2014
Award Nominations: October 9, 2014

August 201416

Immunotoxicology Specialty Section