2011 年に開催したセミナー資料から抜粋した資料です。

ＲＴＥＣＳ ファイルの略 語 一 覧

略語

内容
American Conference ofACGIH

Govermental Industrial
Hygenists

Ccontinuouscc

cubic centimeter

略語
OELORM
OSHA

内容
Occupational Exposure Limit
Other Regulated Material(DOT)
Occupational Safety and
Health Administration

CLceiling concentration

CRIT DOC

NIOSH criteria document

DdayPkpeak concentration

definitionpmol

picomole

Department ofpost

after birth

Transportation

ppb

DEF
DOT
EPA

Environmental Protection
Agencypgpph

picogram (one trillionth of agram; 10-12 grams)

parts per billion (v/v)
parts per hundred (v/v)(percent)

fbfiberppm

gmgramppt

parts per trillion (v/v)

Hhourpreprior to copulationIintermittent

preg

pregnant

International Agency forREGSstandards and regulations

Research on Cancer

rns

rinsed with water

IARCkgL
LC 50
LCLokilogram (one thousandgrams)
liter
lethal concentration

RTECS
SCP

parts per million (v/v)

Registry of Toxic Effects ofChemical SubstancesStandards Completion
Program

50 percent killSsecondlowest published

STEL

Short Term Exposure Limit
Threshold Limit Valuelethal concentration

TLV

LD 50

lethal dose 50 percent kill

TCLDLolowest published lethal doseM

minutem3cubic meterTDmilligram (one thousandth orTDLolowest published toxic dosea gram; 10-3 grams)

TLV

Threshold Limit Value

MGN

multigeneration

TWA

time weighted averagemlmilliliter

mmol

millimolemolmole

mg

mppcf
mulng

million particles per cubic
footTCLoug
umol
USOS

toxic concentration
lowest published toxic
concentration
toxic dose

microgram (one millionth of agram; 10-6 grams)
micromole
U.S. Occupational HealthStandardmultiple routes

Wnanogram (one billionth of aYyeargram; 10-9 grams)%

percent

nmol

nanomolense

non-standard exposure

OBS

obsolete (trade name)weekＲＴＥＣＳ ファイルの ＥＦＦ コード

A Brain and Coverings
Damage Codes
01
Meningeal changes
02
Changes in cerebral spinal fluid
03
Increased intracranial pressure
04
Changes in circulation(hemorrhage, thrombosis, etc.)
05
Encephalitis
06
Demyelination
10
Changes in surface EEG
11Recordings from specific areasof CNS
30
Other degenerative changes
60
Tumors70
Changes in brain weight
B Spinal Cord
Damage Codes
01
02
03
04
30
60

Meningeal changes
Changes in circulation
Inflammatory changes
Demyelination
Other degenerative changes
TumorsC Peripheral Nerve Sensation
Damage Codes
01
Associated connective tissue
02
Sensory syndrome diagnostic ofcentral lesion
03
Sensory change involving
trigeminal nerve
04
Sensory change involving
peripheral nerve
05
Sensory change involving
segmental distribution
06
Spastic paralysis with or without
sensory change
07
Flaccid paralysis with appropriate
anesthesia
08
Flaccid paralysis withoutanesthesia(usually neuromuscular blockage)
09
Fasciculations
10
Paresthesia
15
Recording from afferent nerve
16
Recording from peripheral motornerve
17
Local anesthetic
18
Structural change in nerve orsheath60
Peripheral nerve tumors

DSense Organs and Special Senses(nose, eye, ear, and taste)
Damage Codes
Olfaction:
01
Deviated nasal septum02
Ulcerated nasal septum
03
Change in olfactory nerve
04
Change in sensation of smell
07
Other changes
09
Tumors
Eye:
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
35
Ear:
40
41
43

Optic nerve neuropathy
Cycloplegia
Changes in refraction
Ciliary spasm
Visual field changes
Miosis (pupillary constriction)
Mydriasis (pupillary dilation)
Lacrimation
Chromidacryorrhea
Increased intraocular pressure
Retinal changes (pigmentarydepositions, retinitis, other)
Hemorrhage
Changes in circulation
Diplopia
Changes in extra-ocular muscles
Conjunctive irritation
Corneal damage
IritisPtosisTumorsOther

45

Change in acuity
Tinnitus
Changes in vestibularfunctions
Changes in cochlear structure
or function
TumorsTaste:
50

Change in function

44

ＲＴＥＣＳ ファイルの ＥＦＦ コード

E Autonomic Nervous System
Damage Codes
01
Sympathomimetic
02
Alpha adrenergic blockage
03
Beta adrenergic blockage
04
Central sympatholytic05
Ganglion blocker
06
Ganglion facilitant08
Other (direct)
parasympathomimetic
09
Intensity beta adrenergic effects
15
Smooth muscle relaxant(mechanism undefined,spasmolytic)
16
Parasympatholytic

41
42

F BEHAVIORAL
Damage Codes
01
General anesthetic
02
Anticonvulsant03
Wakefulness
04
Sleep
05
Altered sleep time (includingchange in righting reflex)
06
Euphoria
07
Somnolence (general depressedactivity)
08
Hallucinations, distorted
perceptions
09
Changes in REM sleep (human)
10
Toxic psychosis
11
Tremor12
Convulsions or effect on seizurethreshold
13
Excitement
14
Anorexia (human)
15
Food intake (animal)
16
Fluid intake
17
Change in motor activity (specificassay)
18
Muscle weakness
19Ataxia
20
Stiffness
21
Rigidity (includes catalepsy)
22
Tetany23
Muscle contraction or spasticity
24
Coma
25
Antipsychotic
26
Antianxiety
27
Headache
29
Analgesia
30
Tolerance
31
Withdrawal
32
Abuse
33
Irritability
34
Straub tail40
Alteration of classicalconditioning

0743
G CARDIAC
Damage Codes
01020304050608
09
1011121330
60
70
H VascularDamage Codes
010203040506
0708
15
16
1720
2130
3560

Alteration of operant conditioning
Change in psychophysiologicaltests
Aggression

Cardiomyopathy including
infarction
Changes in coronary arteries
Pericarditis
Arrythmias (including changes inconduction)
Cardiomegaly
EKG changes not diagnostic ofabove
Pulse rate increased without fallin BP
Pulse rate
Change in force of contraction
Change in rate
Change in conduction velocity
Cardiac output
Change in resting or action
potential
Other changes
TumorsChanges in heart weight

BP Elevation not characterized inautonomic section
BP lowering not characterized inautonomic section
Pulse pressure increase
Regional or general arteriolar
constriction
Regional or general arteriolar orvenous dilation
Measurement of regional bloodflow
Change in plasma or blood volume
Shock
Acute arterial occlusion
Structural changes in vessels
Thrombosis distant from injection
site
Contraction (isolated tissues)
Relaxation (isolated tissues)
Other changes
Effects on gills and gill function
TumorsＲＴＥＣＳ ファイルの ＥＦＦ コード

J Lungs, Thorax, or Respiration
Damage Codes
01
Ciliary function changes
02
Structural or functional change intrachea or bronchi
03
Bronchiolar dilation
04
Bronchiolar constriction
05
Bronchiectasis
06
Emphysema
07Changes in pulmonary vascular
resistance08
Consolidation
12
Fibrosis, focal (pneumoconiosis)
13
Fibrosis, interstitial
14
Fibrosing alveolitis
15
Acute pulmonary edema
16
Chronic pulmonary edema
17
Pleural effusion
18
Pleural thickening
20
Respiratory obstruction
21
Cough
22
Dyspnea
23
Sputum24
Cyanosis
25
Respiratory depression
26
Respiratory stimulation
27
Pulmonary emboli
30
Other changes
60
Tumors61
Bronchiogenic carcinoma
70
Changes in lung weight
K Gastrointestinal
Damage Codes
01
Changes in structure or functionof salivary glands
02
Changes in structure or functionof exocrine pancreas
03
Changes in structure or functionof esophagus
04
Alteration in gastric secretion
05
Gastritis
06
Ulceration or bleeding fromstomach
07
Ulceration or bleeding fromduodenum08
Ulceration or bleeding from small
intestine
09
Ulceration or bleeding from large
intestine
12
Hypermotility, diarrhea
13
Nausea or vomiting
14
Decreased motility orconstipation
15
Malabsorption
17
Peritonitis
20
Necrotic changes
30
Other changes

31
32
60
6170
L Liver
Damage Codes
01
02
03
04
111214
15
1930
50
60
6170

Contraction (isolated tissue)
Relaxation (isolated tissue)
TumorsColon tumors
Changes in pancreatic weightHepatitis (hepatocellularnecrosis), diffuse
Hepatitis (hepatocellularnecrosis), zonal
Fatty liver degeneration
Hepatitis, fibrous (cirrhosis,post-necrotic scarring)
Jaundice, cholestatic
Jaundice, other or unclassified
Liver function tests impaired
Change in gall bladder structure
or function
Jaundice (or hyperbilirubinemia)
hepatocellular
Other changes
Multiple effects
TumorsAngiosarcoma
Changes in liver weightM Kidney, Ureter, and Bladder
Damage Codes
01
Changes in blood vessels or incirculation of kidney
02
Changes primarily in glomeruli
03
Changes in tubules (including
acute renal failure, acute tubularnecrosis)
04
Changes in both tubules andglomeruli
05
Interstitial nephritis
10
Urine volume increased
11
Urine volume decreased
12
Renal function tests depressed
13
Proteinuria
14
Hematuria
16
Other changes in urine
composition
20
Inflammation, necrosis, orscarring of bladder
21
Structural or functional changes
in ureter
29
Incontinence
30
Other changes
60
Tumors61
Kidney tumors
70
Changes in bladder weight
71
Changes in kidney weightＲＴＥＣＳ ファイルの ＥＦＦ コードN Endocrine
Damage Codes
010203040506
0708
101213151617181920212223
24
25
3060
6162707172737475
PBloodDamage Codes
01020506
0708
131415161720222324
Antidiruesis
Change in LH
Change in GH
Change in gonadotropins
Thyroid weight (goiter)
Toxic goiter-hypofunction
Evidence of thyroid hyperfunction
Evidence of thyroid hypofunction
Hyperparathyroidism
Adrenal cortex hyperplasia
Adrenal cortex hypoplasia
Aldosternism
Androgenic
Estrogenic
Differential effect of sex orcastration on observed toxicity
Effect on menstrual cycle
Gynecomastia
Diabetes mellitus
Hypoglycemia
KetosisHyperglycemia
Diabetes Insipidus (nephrogenicor CNS)
Other changes
TumorsAdrenal cortex tumors
Thyroid tumors
Changes in endocrine weight
Changes in pituitary weight
Changes in adrenal weight
Changes in spleen weight
Changes in thymus weight
Changes in thyroid weight

Hemorrhage
Change in clotting factors
Normocytic anemia
Microcytosis with or withoutanemiaMacrocytosis
Pigmented or nucleated red bloodcells
Granulocytopenia
Leukopenia
Agranulocytosis
Eosinophilia
Thrombocytopenia
Changes in cell count(unspecified)Oxidant related (GPD deficient)anemiaOther hemolysis with or withoutanemia25262728
3060
61627071
7273

Methemoglobinemia-Carboxyhemo
globinAplastic anemia
Changes in bone marrow notincluded above
Changes in spleen
Changes in serum composition(e.g., bilirubin)
Other changes
Tumors
Leukemia
Lymphomas including Hodgkin's
diseaseChanges in other cell count(unspecified)
Changes in erythrocyte (RBC) cellcount
Changes in leucocyte (WBC) cellcount
Changes in platelet countQ
Musculoskeletal* 筋 肉 の 変 化 (CNS) お よび metabolic な変 化 については，コード F (Behavioral) も参 照
Damage Codes
01
Changes in teeth and supportingstructures
02
Osteoporosis
10
Osteomalacia
15Joints
30
Other changes
60
TumorsRSkin and Appendages
Damage Codes
Skin:
After systemic exposure:01
Dermatitis, allergic
02
Dermatitis, irritative
03
Dermatitis, other04
Photosensitivity
After topical application:
10
Primary irritation
11
Corrosive
12
Dermatitis, allergic
13
Cutaneous sensitization(experimental)
14
Photosensitivity
Other:
20
21
22
25
30
60

SweatingHairNails
BreastOther glands
TumorsＲＴＥＣＳ ファイルの ＥＦＦ コードS
Immunological including Allergic
Damage Codes
01
Increase in cellular immune
response02
Decrease in cellular immune
response
03
Increase in humoral immune
response04
Decrease in humoral immune
response05
Decreased immune response
06
Increased immune response
Allergic (Multiple organ involvement)* 特 定 の臓 器 に関 するアレルギーは，各 臓 器 のEFF コードも参 照- Cholestatic jaundice ： コード L (Liver)- Aplastic anemia, agranulocytoses： コード P (Blood)- Allergic dermatitis： コード R (Skin)
15
Anaphylaxis
16
Other immediate (humoral):urticaria, allergic rhinitis, serumsickness
18
Hypersensitivity delayed
20
Autoimmune
25
UncharacterizedT

Reproductive including Embryotoxic, Neonatal
and Teratogenic
Damage Codes
Paternal Effects:
01
Spermatogenesis (including
genetic material, spermmorphology, motility, and count)
02
Testes, epididymis, sperm duct
03
Prostate, seminal vessicle,
Cowper's gland, accessory glands
04
Impotence05
Breast development
09
Other effects on male
Maternal Effects:
11
Oogenesis
12
Ovaries, fallopian tubes
13
Uterus, cervix, vagina
14
Menstrual cycle changes ordisorders
15
Breasts, lactation (prior to orduring pregnancy)
16
Parturition
17
Postpartum
19
Other effects on females

Effects on Fertility:
21
Mating performance (e.g., numberof sperm positive females pernumber of females mated; numberof copulations per number ofestrus cycles)
22
Female fertility index (e.g.,number of females pregnant per
number of sperm positive females;
number of females pregnant per
number of females mated)
23
Male fertility index (e.g., numberof males impregnating females pernumber of males exposed tofertile nonpregnant females)24
Pre-implantation mortality (e.g.,
reduction in number of implants
per female; total number ofimplants per corpora lutea)
25
Post-implantation mortality (e.g.,dead and/or resorbed implants
per total number of implants)
26
Litter size (e.g., number offetuses per litter; measured
before birth)27
Abortion
29
Other measures of fertility
Effects on Embryo or Fetus:
31
Extra embryonic structures (e.g.,placenta, umbilical cord)
32
Maternal-fetal exchange
33
Cytological changes (including
somatic cell genetic material)
34
Fetotoxicity (expect death, e.g.,stunted fetus)
35Fetal death
39
Other effects to embryo or fetus

ＲＴＥＣＳ ファイルの ＥＦＦ コード

Specific Developmental Abnormalities:
41
Central nervous system
42
Eye, ear
43
Craniofacial (including nose andtongue)
44
Skin and skin appendages
45
Body Wall
46
Musculoskeletal system
47
Cardiovascular (circulatory)
system
48
Blood and lymphatic systems(including spleen and marrow)
49
Respiratory system
50
Gastrointestinal system
51
Hepatobiliary system
52
Endocrine system
53
Urogenital system
54
Immune and reticuloendothelialsystem
55
Homeostatis
59
Other developmentalabnormalities
Tumorigenic Effects:
61
Testicular tumors62
Prostate tumors
63
Ovarian tumors
64
Uterine tumors
65
Transplacental tumorigenesis
69
Other reproductive system
tumors
Effects on Newborn:
71
Stillbirth72Live birth index (similar to T26 ,except measured after birth)73
Sex ratio
74
Apgor score (human only)75
Viability index (e.g., number aliveat day 4 per number born alive)76
Weaning or lactation index (e.g.,number alive at weaning per
number alive at day 4)
77
Other neonatal measures or
effects
81
Growth statistics (e.g., reducedweight gain)
82
Germ cell effects (in offspring)
83Biochemical and metabolic
84
Drug dependence
85
Behavioral
86
Physical87
Other postnatal measures oreffects
91
Delayed effects

U
Nutritional And Gross Metabolic* コード Y (Biochemical) も参 照
Damage Codes
01
Weight loss or decreased weightgain
02
Conditioned vitamin deficiency
03
Dehydration
Changes in:
05
06
07
08
09
10
1120
21
25
2830

Na
ClCaPFeK
Other metals
Metabolic acidosis
Metabolic alkalosis
Body temperature increase
Body temperature decrease
Other changes

V TUMORIGENIC
Damage Codes
01
Carcinogenic by RTECS criteria
02
Neoplastic by RTECS criteria
03
Equivocal tumorigenic agent by
RTECS criteria
05
Cells (cultured) transformed
08
Increased incidence of tumors insusceptible strains
10
Tumors at site of application
15
Tumor types after systemic
administration not seen
spontaneously
16
Facilitates action of known
carcinogens
25
Protects against induction ofexperimental tumors
30
Active as anti-cancer agent

ＲＴＥＣＳ ファイルの ＥＦＦ コード

Y Biochemical
Damage Codes
Enzyme inhibition, induction, or change in blood ortissue levels:
01
True cholinesterase
02
Other esterases
03
Phosphatases
04
Other hydrolases
05
Carbonic anhydrase
06
Xanthine oxidases
07
Hepatic microsomal mixed oxidase(dealkylation, hydroxylation, etc.)
08
Monoamine oxidase
09
Cytochrome oxidases (includingoxidative phosphorylation)
10
Dehydrogenases
11Catalases
12
Other oxidoreductases
13Phosphokinase
14Hexokinases
15Transaminases
16
Other transferases
17Peptidases
18Proteases
19
Isomerases
20
Multiple enzyme effects
21
Other enzymes
23
Reactivates cholinesterase
Effect on specific coenzyme:
25
B vitamin including folate
26
CoA
27
NAD, NADP
28
Others29
Proportion of isoenzymes
30
Disturbed regulation

37
38
3940
41
42444550
5152
5354
55

Lipids including transport
Amino acids (including renalexcretion)
Plasma proteins not involving
coagulation
Other proteins
Glycolytic
TCS cycle
Other carbohydrates
Histamines (including liberation
not immunochemical in origin)
Effect on mitochondrial function
Effect on active transport
Effect on Na-K pump
Other
Effect on cyclic nucleotides
Effect on inflammation or
mediation of inflammation

Neurotransmitters or modulators (putative):
60
Catecholamine levels insympathetic nerves
61
Catecholamine levels in CNS
64
Dopamine in striatum
65
Dopamine at other sites
Z
RELATED TO CHRONIC DATA
Damage Codes
01
Death in the Other Multiple Dosedata type field
Changes in:
71727374

Ovarian weight
Prostate weight
Testicular weight
Uterine weight

Metabolism (intermediary):
35
Xanthine, purine, or nucleotides
including urate
36
Porphyrin including bile pigments■ EFF フィールドコードは，EXPAND して毒 性 の種 類 や程 度 を確 認 することもできる．
=> E D25/EFF 5
E123
D24/EFFE223
D24 (CHANGE IN EXTRA-OCULAR MUSCLES)/EFF
E3454 --> D25/EFF
E4454
D25 (CONJUNCTIVE IRRITATION)/EFF
E5148
D26/EFF