䝬䜴䝇䞉䝷䝑䝖⏝↓ຍ ᆺ㠀ほ⾑ᘧ⾑ᅽィModel MK-2000ST

Capable of recording from neonatal mice (1.4 g) to the aged rats (1 kg)

MUROMACHI KIKAI CO., LTD.

1/8ᚑ᮶ࠊࣛࢵࢺࡸ࣐࢘ࢫ➼ࡢᑠື≀ࡢ⾑ᅽࢆ ᐃࡍࡿⅭ࡟ࡣࠊຍ ⿦⨨ࢆ౑⏝ࡋ࡚ື≀ࢆᬮࡵ࡚࠾ࡃᚲせࡀ࠶ࡾࡲࡋࡓࠋື≀ࢆᬮࡵࡿ࡜ࠊ⇕࡟ࡼࡿࢫࢺࣞࢫࡀ࠿࠿ࡗ࡚ࡋࡲ࠸ࡲࡍࡀࠊᬮࡵ࡞ࡅࢀࡤ ᐃࡀฟ᮶࡞࠸Ⅽࠊຍ ࡟ࡼࡿື≀࡬ࡢࢫࢺࣞࢫࡣ↓どࡉࢀ࡚ࡁࡲࡋࡓࠋ
ࡋ࠿ࡋࠊMK-2000STࡣࡣ ⊂⮬ࡢࢸࢡࣀࣟࢪ࣮࡟ࡼࡾ ࠊ ᐊ ࡀ23Υ௨ୖ࠶ࢀࡤ⮬↛ࡢ㸦↓ຍ ࡢ㸧≧ែࡢࡲࡲ࡛ ᐃࢆ⾜࡞࠺ࡇ࡜ࡀ࡛ࡁࡲࡍࠋື≀࡟ᑐࡋ࡚ࠊ⇕ࢫࢺࣞࢫࢆ୚࠼ࡿࡇ࡜ࡀ↓࠸Ⅽࠊື≀࡟ࡶඃࡋࡃࠊᇶ♏⾑ᅽࢆ ᐃࡍࡿࡢ࡟ࡶࠊ⸆≀ࡢᙳ㡪ࢆㄪ࡭ࡿ㝿࡟ࡶࠊࡼࡾ⮬↛࡞≧ែ࡛ࡢ⾑ᅽࢆồࡵࡿࡇ࡜ࡀྍ⬟࡛ࡍࠋࢧ࢖ࢬࡣ㠀ᖖ࡟ࢥࣥࣃࢡࢺ࡛࠶ࡾࠊሙᡤࢆྲྀࡾࡲࡏࢇࠋࡲࡓࠊࣉࣜࣥࢱࡣᮏయ࡟ෆⶶࡉࢀ࡚࠾ࡾࡲࡍࡢ࡛ࠊࢫࢱࣥࢻ࢔࣮࡛ࣟࣥࡢ✌ാࡀྍ⬟࡛ࡍࠋ
1༉ࡢື≀࡟ᑐࡋ࡚ᑿື⬦ᅽࡢ⤒᫬ኚ໬ࢆࣔࢽࢱࡍࡿࡇ࡜ࡶ࡛ࡁࠊᚑ᮶ࡢ㠀ほ⾑ᘧ⾑ᅽィࡢᴫᛕࢆそࡍ⏬ᮇⓗ࡞⿦⨨࡛ࡍࠋ᧯సࡣ⮳ࡗ࡚⡆༢࡛ࠊື≀ࢆ ᐃྎ࡟ࢭࢵࢺࡋࡓᚋࡣ࣎ࢱࣥࢆᢲࡍࡔࡅࡢ඲⮬ື ᐃࡀ⾜࡞࠼ࡲࡍࠋ

2/8䝔䞊䝹䜹䝣᪉ᘧ䛾Ⅽ䚸≉ู䛺ᡭᢏ䜔ື≀䜈䛾ᡭ⾡䛿ᚲせ䛒䜚䜎䛫䜣䚹ග㟁⬦Ἴἲ࡟ࡼࡾ᳨ฟࡉࢀࡓᑿື⬦ࡢ⬦Ἴࡢ᣺ᖜࢆࢥࣥࣆ࣮ࣗࢱࡀ࡜ࡽ࠼ࠊ
ࡑࡢࣆ࣮ࢡࢆࢹ࢕ࢫࣉࣞ࢖ୖ࡟ࣉࣟࢵࢺࡋ࡚࠸ࡁࡲࡍࠋ⦪㍈࡟⬦Ἴࡢ᣺ᖜࠊᶓ㍈࡟࢝ࣇᅽࡀ⾲♧ࡉࢀࡲࡍࠋࡇࡢ᪉ᘧࢆ᥇⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊ⏬㠃ୖ࡛ࣀ࢖ࢬ࡜ಙྕࡢ㆑ูࡀᐜ᫆࡜࡞ࡾࠊࡼࡾಙ㢗ᛶࡢ㧗࠸⾑ᅽ ᐃࢆ⾜࡞࠺ࡇ࡜ࡀ࡛ࡁࡲࡍࠋ
2✀㢮ࡢ࣮ࣔࢻࢆ㑅ᢥࡋ࡚ ᐃ࡛ࡁࡲࡍࠋ
MODE1
MODE2

HR
HR

SBP
SBP

MBP(DBP)ὀ㸸HR ⬦ᢿᩘ ࠊSBP ཰⦰ᮇ⾑ᅽ ࠊMBP ᖹᆒ⾑ᅽ ࠊDBP ᣑᙇᮇ⾑ᅽࠊィ⟬್ ࢫࢱ࣮ࢺࢫ࢖ࢵࢳࢆᢲࡍ࡜኱ࡲ࠿࡞SBPࢆồࡵ࡚⣙30mmHg/sec࡛ຍᅽࡋ࡚࠸ࡁࡲࡍࠋࡑࡢ
ᚋᩘmmHg/sec࡛ῶᅽࡋ࡚SBPࢆồࡵࡲࡍࠋMODE2࡛ࡣ᭦࡟࢝ࣇᅽࢆ㛫Ḟⓗ࡟㝆ୗࡉࡏࠊ⬦Ἴࡢ᭱኱᣺ᖜⅬ(MBP)ࢆồࡵࡲࡍࠋDBPࡣSBP࠾ࡼࡧMBP࠿ࡽồࡵࡓィ⟬್࡛ࡍࠋィ⟬ᘧ㸸(3MBP-SBP)¹2



㐃⥆



㧗㏿༳Ꮠᶵ⬟㺃㺃㺃㺃㺃㧗㏿࡛㡢ࡢ㟼࠿࡞ࢧ࣮࣐ࣝࣉࣜࣥࢱࢆ᥇⏝ࡋࡲࡋࡓࠋᖹᆒ್(AV)ࡸSD್ࢆྵࡵࡓ඲࡚ࡢࢹ࣮ࢱࡀ⣙1⛊㛫࡛༳Ꮠࡉࢀࡲࡍࠋཪࠊᐇ㦂⪅ࡢุ᩿࡟ࡼࡾ ᐃࢹ࣮ࢱࡢ๐㝖ࢆ⾜࡞࠺ࡇ࡜ࡶ࡛ࡁࡲࡍࠋ

ࡇࢀࡲ࡛ ᐃࡀᅔ㞴࡛࠶ࡗࡓC57BL6ࡢࡼ࠺࡞᭷Ⰽ࣐࢘ࢫࡸࢿ࢜ࢿ࢖ࢱ࣭࣐ࣝ࢘ࢫ(1.4g)ࠊ
ࣁ࣒ࢫࢱ࣮㸦㯞㓉ୗ㸧ཬࡧࣔࣝࣔࢵࢺ㸦ぬ㓰᫬㸧ࠊ࣐࣮ࣔࢭࢵࢺ➼࡛ࡶ ᐃ࡛ࡁࡲࡍࠋᡭ⾡୰ࡢື≀ࡢ⾑ᅽࡶࣔࢽࢱ࡛ࡁࡲࡍࠋ㸦ࢩࣙࢵࢡ≧ែࡢື≀࡛ࡶ ᐃࡀྍ⬟࡛ࡍࠋ㸧࣐ࣝࢳࢳࣕࣥࢿࣝࡣࡶ࠺୙せ࡛ࡍࠋ࢔ࢽ࣐ࣝ࣍ࣝࢲࢆ」ᩘ⏝ពࡋ࡚࠾ࡅࡤḟ࠿ࡽḟ࡜ ᐃ࡛ࡁࡲࡍࠋࣔࢽࢱᶵ⬟㺃㺃㺃㺃㺃タᐃࡉࢀࡓ ᐃ㛫㝸(1㹼99min)࡜ ᐃᅇᩘ࡟ᛂࡌ࡚ࠊ୍༉ࡢᐇ㦂ື≀ࡢᑿື⬦ᅽࢆ⤒᫬ⓗ࡟ ᐃࡋࠊࢹ࣮ࢱࡢ༳Ꮠཬࡧࣃࢯࢥࣥ࡬ࡢ㌿㏦ࡲ࡛ࡢ୍㐃ࡢసᴗࢆ඲⮬ື࡛⾜࠺ᶵ⬟ࡀഛࢃࡗ࡚࠸ࡲࡍࠋࢱ࢖࣒ࢫࢱࣥࣉᶵ⬟㺃㺃㺃㺃㺃ࢹ࣮ࢱ༳Ꮠࡢ㝿࡟ィ ᫬้ࡶ༳Ꮠࡉࢀࡲࡍࠋ⏬㠃ࢥࣆ࣮ᶵ⬟㺃㺃㺃㺃㺃PrtScreen࣮࢟ࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡾ⏬㠃ࡢࣁ࣮ࢻࢥࣆ࣮ࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡲࡍࠋ
56&࢖ࣥࢱ࣮ࣇ࢙࣮ࢫࡀᶆ‽⿦ഛࡉࢀ࡚࠾ࡾࠊࣃ࣮ࢯࢼࣝࢥࣥࣆ࣮ࣗࢱ࡟ࢹ࣮ࢱࢆ㌿㏦ࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋᶆ‽௜ᒓࡢࢹ࣮ࢱཷಙࢯࣇࢺ(DCS-2000ST Windows∧)ࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡾࠊᚓࡽࢀࡓࢹ࣮ࢱࢆ࢚ࢡࢭࣝ➼ࡢ⾲ィ⟬ࢯࣇࢺ࡛㹁㹑㹔ࣇ࢓࢖ࣝ࡜ࡋ࡚ಖᏑࡍࡿࡇ࡜ࡀ࡛ࡁࡲࡍࠋᐃᶵ⬟㺃㺃㺃㺃㺃᭱㧗9ᅇࡲ࡛㐃⥆ࡋ࡚⮬ືᐃࢆ⾜࡞࠺ࡇ࡜ࡀ࡛ࡁࡲࡍࠋ

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Correlation between simultaneously recorded blood pressures (BP) fromcarotid catheter and BP measured with the Model MK-2000 in mice. Good
correlation was seen in a wide range of BP, which was induced by i.v. infusionsof pressor or depressor agents.

The data was offered courtesy of Prof. Tomoyuki Kuwaki, Ph.D.,
Department of Physiology, Graduate School of Medical & Dental Science,Kagoshima University

4/8ᐃ୰䚸⬦䛾Ἴᙧ䛜䝕䜱䝇䝥䝺䜲䛻䝸䜰䝹䝍䜲䝮䛷⾲♧䛥䜜䜎䛩䛾䛷䚸ື≀䛾≧ែ䜢ᢕᥱ䛧䚸ṇ☜䛻ᐃ䛜ฟ᮶䛶䛔䜛䛛☜ㄆ䛩䜛䛣䛸䛜ྍ⬟䛷䛩䚹ື≀䜈䛾ຍ 䛿୙せ䛷䛩䚹ື≀䛻ᑐ䛧䛶䛾䝎䝯䞊䝆䛜↓䛔䛾䛷䝛䜸䝛䜲䝍䝹䠄᪂⏕௘䠅䜔⪁㱋ື≀䚸⑓ែ䝰䝕䝹ື≀➼䛷䜒Ᏻ඲䛻 ᐃ䛩䜛䛣䛸䛜ྍ⬟䛷䛩䚹௒䜎䛷ィ䛜㞴䛧䛛䛳䛯C57BL6䝬䜴䝇䛷䜒 ᐃ䛜䛷䛝䜎䛩䚹䝷䝑䝖䞉䝬䜴䝇䛰䛡䛷䛺䛟䚸䝝䝮䝇䝍䞊䠄㯞㓉ୗ䠅䜔䝰䝹䝰䝑䝖䚸䝬䞊䝰䝉䝑䝖➼䛷䜒 ᐃ䛜ྍ⬟䛷䛩䚹䢄䡱䢄䡮䡼䢕䢓䡫䢀䢏䢕䢏䡫䢀䝝䝮䝇䝍䞊*䝝䝮䝇䝍䞊䚸䝰䝹䝰䝑䝖䛿ᑿ䛷䛿䛺䛟䚸⬮䛷 ᐃ䛧䜎䛩䚹௜ᒓရ䛾䝕䞊䝍ཷಙ䝋䝣䝖䜢౑⏝䛩䜜䜀PC䜈䝕䞊䝍䜢㌿㏦䛩䜛䛣䛸䛜ྍ⬟䛷䛩䚹䝕䞊䝍䛿
CSVᙧᘧ䛷ಖᏑ䛥䜜䜎䛩䛾䛷䚸EXCEL䛷⾲♧ྍ⬟䛷䛩䚹䝕䞊䝍ཷಙ䝋䝣䝖

EXCEL⾲♧5/8ᮏ    య 㻌SBPࣃࣝࢫฟ⌧Ⅼࡢ࢝ࣇᅽ㻌MBPῶᅽ᫬࡟࠾ࡅࡿࣃࣝࢫࡢ᭱኱᣺ᖜⅬࡢ࢝ࣇᅽ㻌DBPィ⟬್ (3MBP-SBP)/2㻌ࢭࣥࢧ㒊㻌LED, ࣇ࢛ࢺࢺࣛࣥࢪࢫࢱ㻌ຍᅽ⠊ᅖ㻌0 - 350mm Hg㻌グ㘓⣬㻌ឤ⇕グ㘓⣬ࠊ58mm ᖜ(TSP-10)㻌
᪥௜ࠊ᫬㛫ࠊື≀␒ྕࠊయ㔜༳Ꮠෆᐜ㻌ᐃ࣮ࣔࢻࠊ ᐃ㛫㝸ࠊ ᐃᅇᩘᐃ㡯┠ཬࡧᖹᆒ್࡜ SD ್ࠊィ ᫬้㻌㟁  ※㻌100VAC 50/60Hz

እᙧᑍἲ㻌

W210 × D310 × H210 mm㔜  㔞㻌

⣙8 kg㻌࣮࣮࢟࣎ࢻ㻌࣮࢟㻌ᶆ ‽ ᵓ ᡂ㻌

33

ᮏయ(ࣉࣜࣥࢱྵࡴ)

1

እᙧᑍἲ㻌

W145 × D120 × H20 mm࣮࣮࢟࣎ࢻ1㔜  㔞㻌

⣙ 0.4 kgࣛࢵࢺ⏝ ᐃྎ

1࢔ࢽ࣐ࣝ࣍ࣝࢲ(௵ពࡢ 1 ಶ㑅ᢥ)1࢝ࣇࣃࣝࢫ࣭ࢭࣥࢧ(௵ពࡢ 1 ಶ㑅ᢥ)1

DCS-2000ST ࢹ࣮ࢱཷಙࢯࣇࢺ(Windows ∧)1TSP-10 グ㘓⣬ 㸦5 ᕳධ㸧

1APC-2000 ࢔ࢡࢭࢧࣜࢣ࣮ࢫAPC1ࢲࢫࢺ࢝ࣂ࣮
ࢲࢫ

16/8䜰䝙䝬䝹䝩䝹䝎㻌䜹䝣䝟䝹䝇䝉䞁䝃㻌

Mouse Holder (3S)㻌

5-10g㻌

Neo24NH㻌

1.4 - 2g㻌Mouse Holder (SS)㻌

10-20g㻌

Neo32NH㻌

2 - 5g㻌

Mouse Holder (S)㻌20-30g㻌

Neo40NH㻌

5 - 10g㻌

Mouse Holder (M)㻌30-40g㻌

Mouse NH㻌

20-50g㻌

Mouse Holder (L)㻌40-50g㻌

Small Mouse NH

Mouse 10-20g

Fatty Mouse Holder䠄S䠅50-70g

C57 Mouse NH㻌

C57BL6 Mouse㻌

Fatty Mouse Holde(L)70-90gHamster (S) NH㻌

Approx. 60-80g㻌

Rat Holder (3S)㻌

50-70g㻌Hamster (M) NH㻌

Approx. 80-120g㻌

Rat Holder (SS)㻌

70-90g㻌Hamster (L) NH㻌

Approx.120-160g㻌

Rat Holder (S)㻌90-150g㻌

Rat (S)NH㻌

90-210g㻌

Rat Holder (SM)㻌

150-210g㻌

Rat (M)NH㻌

210-350g㻌

Rat Holder (M)㻌210-270g㻌

Rat (ML)NH㻌

350-500g㻌

Rat Holder (ML)㻌

270-350g㻌

Rat (L)NH㻌

500-800g㻌

Rat Holder (L)㻌350-500g㻌

Rat Holder (LL)㻌

500-800g㻌

Rat Holder(3L)

800-1kg䜹䝣䝟䝹䝇䝉䞁䝃
Rat Holder

Mouse Holder

Mouse Holder stand⫧‶䝬䜴䝇⏝䝩䝹䝎
FMH-S, FMH-Lእほཬ䜃௙ᵝ䛿ᨵⰋ䛾䛯䜑ண࿌䛺䛧䛻ኚ᭦䛩䜛ሙྜ䛜䛒䜚䜎䛩䛾䛷䛤஢ᢎ㢪䛔䜎䛩䚹

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Bland, R. D., et al. (2007). Mechanical ventilation with 40% oxygen reduces pulmonary
expressionof genes that regulate lung development and impairs alveolar septation in newborn mice.
Am J Physiol Lung Cell Mol Physiol, 293(5), L1099-L1110.
Egami, K., et al. (2003). Role of host angiotensin II type 1 receptor in tumor angiogenesis andgrowth. J Clin Invest, 112(1), 67-75.
Ishiguro, K., et al. (2001). Syndecan-4 deficiency leads to high mortality of lipopolysaccharideinjected mice. J Biol Chem, 276(50), 47483-47488.
Ishiguro, K., et al. (2005). Development of an in vivo bioassay method for allergy-preventive
substances using hen-egg white lysozyme (HEL)-induced blood flow decrease. Biol Pharm Bull,
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Iwamoto, T., et al. (2004). Salt-sensitive hypertension is triggered by Ca2+ entry via Na+/Ca2+exchanger type-1 in vascular smooth muscle. Nature Med, 10(11), 1193-1199.
Iwase, M., et al. (2004). Growth hormone-releasing peptide can improve left ventricular
dysfunction and attenuate dilation in dilated cardiomyopathic hamsters. Cardiovasc Res, 61(1), 3038.
Kato, Y., et al. (2003). Progressive development of pulmonary hypertension leading to rightventricular hypertrophy assessed by echocardiography in rats. Exp Anim, 52(4), 285-294.
Kato, Y., et al. (2003). Validity and application of noninvasive measurement of blood pressure inhamsters. Exp Anim, 52(4), 359-363.
Khattab, M. M., et al. (2005). Effects of captopril on cardiac and renal damage, and metabolic
alterations in the nitric oxide-deficient hypertensive rat. Kidney Blood Press Res, 28(4), 243-250.
Kubota, Y., et al. (2006). Evaluation of blood pressure measured by tail-cuff methods (withoutheating) in spontaneously hypertensive rats. Biol Pharm Bull, 29(8), 1756-1758.
Lee, N. Y., et al. (2006). Antihypertensive Effect of Angiotensin-Converting Enzyme Inhibitory
Peptide Obtained from Hen Ovotransferrin. J Chine Chem Soc, 53, 495-501.
Mashimo, T., et al. (2005). Rat Phenome Project: the untapped potential of existing rat strains. JAppl Physiol, 98(1), 371-379.
Matoba, N., et al. (2001). Design and production of genetically modified soybean protein withanti-hypertensive activity by incorporating potent analogue of ovokinin(2-7). FEBS Lett, 497(1),50-54.
Murakami, S., et al. (2006). Prostacyclin agonist with thromboxane synthase inhibitory activity(ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell
Mol Physiol, 290(1), L59-L65.
Shimada, T., et al. (2004). Angiogenesis and vasculogenesis are impaired in the precocious-aging
klotho mouse. Circulation, 110(9), 1148-1155.
Toh, R., et al. (2005). An X-Ray diffraction study on mouse cardiac cross-bridge function in vivo:
effects of adrenergic {beta}-stimulation. Biophys J, 90(5), 1723-1728.
Yamada, Y., et al. (2002). Design of a highly potent anti-hypertensive peptide based onovokinin(2-7). Biosci Biotechnol Biochem, 66(6),1213-1217.
Yu, J., et al. (2004). The vascular relaxing effects of sevoflurane and isoflurane are more
important in hypertensive than in normotensive rats. Can J Anaesth, 51(10), 979-985.r. Biochem J,53(3), 412-420.

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