Room 1
Invited Lecture

June 30 (Thu) 9:30 - 10:30 Room 1

Chair: Mayumi ISHIZUKA (Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University)IL

The Potential of Environmental Toxicology for Promoting One Health
Hisato IWATA (Center for Marine Environmental Studies, Ehime University)

Special Lecture

June 30 (Thu) 10:45 - 11:45 Room 1

Chair: Masahiko SATOH (School of Pharmacy, Aichi Gakuin University)
6/(ႇHFWVRIPHWK\OPHUFXU\H[SRVXUHRQIHWXVHVMineshi SAKAMOTO (National Institute for Minamata Disease)
Room 2

Symposium 1

June 30 (Thu) 9:30 - 11:30 Room 2)XUWKHU'HYHORSPHQWRI0362YHUWKH'HYLO5LYHUDQG9DOOH\RI'HDWK
Chairs: Seiichi ISHIDA (Graduate School of Engineering, Department of Life Science, Sojo University)
Tetsuro ARAKI (Toxicological Research Laboratories, Translational Research Unit, R&D Division, Kyowa
Kirin Co., Ltd.)6
9:30 - 9:50

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Kazuo TAKAYAMA1, 2 (1Center for iPS Cell Research and Application, Kyoto University, 2AMED-CREST)'HYHORSPHQWRIWZRRUJDQFRQQHFWHGGHYLFHFRQGXFWHGE\$0('036
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Tamihide MATSUNAGA (Department of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences,
Nagoya City University)6
10:10 - 10:30

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10:30 - 10:50

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Hiroyuki MORIGUCHI1, 2 (1Stem Cell Evaluation Technology Research Association, 2Astellas Pharma Inc.)'LVFXVVLRQRI036GHYHORSPHQWLVVXHVIURPDUHJXODWRU\VFLHQFHSHUVSHFWLYH
Seiichi ISHIDA (Graduate School of Engineering, Department of Life Science, Sojo University)$VVD\SODWIRUPRI2UJDQRQDFKLSIRUGUXJGLVFRYHU\Paul VULTO &KLHI([HFXWLYH2൶FHU FRIRXQGHUDW0,0(7$6'LVFXVVLRQ
11:10 - 11:30

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6/30 AMDay 1 AM (June 30 (Thu))Room 3
6/30 AM

Symposium 2

June 30 (Thu) 9:30 - 11:30 Room 3&DVHVWXG\,VWKHLQIRUPDWLRQRQWKHRQWDUJHWWR[LFLW\RINQRFNRXWPRXVH
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Chairs: Hideo FUKUI (Axcelead Drug Discovery Partners, Inc.)
Kazuhiko MORI (Daiichi Sankyo RD Novare Co., Ltd.)6
9:30 - 10:00

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10:00 - 10:30

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10:30 - 11:00

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Kazunori FUJIMOTO (Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.)525ȖWLQKLELWRUGUXJHႈFDF\DQGULVNRIVLGHHႇHFWV
Azumi UEYAMA 6KLRQRJL &R/WG*HQHUDWLRQRIKXPDQL]HGPRXVHXVLQJJHQRPHHGLWLQJDQGLWVDSSOLFDWLRQSatoru TAKAHASHI (Transborder Medical Research Center, Faculty of Medicine, University of Tsukuba)&UHDWLRQDQGDQDO\VLVRI3.'NQRFNRXWF\QRPROJXVPRQNH\VDQGWKHIXWXUHGLUHFWLRQ
Masatsugu EMA (Research Center of Animal Life Science, Shiga University of Medical Science)
Room 4

Symposium 3

June 30 (Thu) 9:30 - 11:30 Room 4&XUUHQWJHQRWR[LFUHVHDUFK+D]DUGLGHQWL¿FDWLRQDQGULVNDVVHVVPHQWIRU
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Chairs: Kei-ichi SUGIYAMA (Division of Genetics and Mutagenesis, Center for Biological Safety and Research,
National Institute of Health Sciences)

Masayuki MISHIMA (Translational Research Division, Chugai Pharmaceutical),QWURGXFWLRQ
9:30 - 9:35
Kei-ichi SUGIYAMA (Division of Genetics and Mutagenesis, Center for Biological Safety and Research,
National Institute of Health Sciences)6
9:35 - 9:58

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9:58 - 10:21

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10:21 - 10:44*HQRWR[LFLW\DVVHVVPHQWRIQHZPRGDOLW\GUXJV
Masayuki MISHIMA (Translational Research Division, Chugai Pharmaceutical)
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Kiyohiro HASHIMOTO (Drug Safety Research and Evaluation, Takeda Pharmaceutical Co., Ltd.)&XUUHQW6WDWXVDQG)XWXUH3URVSHFWVRI*HQRWR[LFLW\$VVHVVPHQWRI
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Yukari TOTSUKA1, 2 (1Laboratory of Environmental Toxicology and Carcinogenesis, Nihon University School
2of Pharmacy, National Cancer Center Research Institute)6
10:44 - 11:07

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11:07 - 11:30

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FKURPRWKULSVLVTakayoshi SUZUKI (Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences)(ႇHFWRIDWR[LFFRPSRXQGGHULYHGIURPJO\FRO\VLVRQQXFOHDUGLYLVLRQDQG
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Yoshiharu INOUE (Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University)

Symposium 4

June 30 (Thu) 9:30 - 11:30 Room 5)XUWKHUXWLOL]DWLRQRIFOLQLFDODQGQRQFOLQLFDO&',6&VWDQGDUGGDWDLQQHZ
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Chairs: Osamu FUEKI (Pharmaceuticals and Medical Devices Agency)
Mutsumi SUZUKI (Kyowa Kirin Co., Ltd. R&D Division, Translational Research Unit, Toxicological ResearchLaboratories),QWURGXFWLRQ
9:30 - 9:35

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9:35 - 9:55

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9:55 - 10:15

6
10:15 - 10:35

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10:35 - 11:00

6(1'DQGLWVXWLOL]DWLRQGen SATO *OREDO1RQFOLQLFDO5HJXODWRU\$൵DLUV(LVDL&R/WG
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Osamu KOMIYAMA (Japan Pharmaceutical Manufacturers Association (JPMA))6XEPLVVLRQDQGXWLOL]DWLRQRI&',6&VWDQGDUGL]HGGDWDIRUQHZGUXJDSSOLFDWLRQ
Yuki ANDO (Pharmaceuticals and Medical Devices Agency)
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Hiroshi KASUGA (Pharmaceuticals and Medical Devices Agency)'LVFXVVLRQ
11:00 - 11:25&RQFOXVLRQ
11:25 - 11:30

Room 6
Symposium 5

June 30 (Thu) 9:30 - 11:30 Room 6.627-627-RLQW6\PSRVLXP8SGDWHRQOXQJWR[LFLW\
Chairs: Byung-Sun CHOI (College of Medicine, Chung-Ang University)
Gi-Wook HWANG (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University)
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9:30 - 9:32

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9:32 - 10:01,QKDODWLRQ7R[LFLW\6WXGLHVIRU&KORURPHWK\OLVRWKLD]ROLQRQHDQG
0HWK\OLVRWKLD]ROLQRQH &0,70,7Kyuhong LEE1, 2, 3 (1Inhalation Toxicology Center for Airborne Risk Factor, Korea Institute of Toxicology,
2'HSDUWPHQWRI+XPDQDQG(QYLURQPHQWDO7R[LFRORJ\8QLYHUVLW\RI6FLHQFH 
34

Technology, +XPLGL¿HU'LVLQIHFWDQW+HDOWK&HQWHU , College of Pharmacy, Ewha Womans
University)6
10:01 - 10:30

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10:30 - 10:59

$GYHUVHKHDOWKHႇHFWVRIKXPLGL¿HUGLVLQIHFWDQWVLQ.RUHDWR[LFPHFKDQLVPRISRO\KH[DPHWK\OHQHJXDQLGLQHSKRVSKDWHHa Ryong KIM (College of Pharmacy, Daegu Catholic University)
3XOPRQDU\WR[LFLW\RIQDQRPDWHULDOVDQGSDUWLFOHVGaku ICHIHARA (Tokyo University of Science)e23

6/30 AM

Room 56
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10:59 - 11:28

,PSDFWVRIVLOLFDDQGDVEHVWRVH[SRVXUHRQLPPXQHIXQFWLRQVDQG
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11:28 - 11:30

Room 7
Symposium 6

June 30 (Thu) 9:30 - 11:30 Room 7,PSDFWDVVHVVPHQWRIFKHPLFDOVRQHQYLURQPHQWDORUJDQLVPVChairs: Satoshi FURUKAWA (Biological Research Laboratories, Nissan Chemical Corporation)
Kosei INUI (Ishihara Sangyo Kaisha, Ltd.),QWURGXFWLRQ
9:30 - 9:35
Kosei INUI (Ishihara Sangyo Kaisha, Ltd.)6
9:35 - 9:55

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9:55 - 10:20(QGRFULQH'LVUXSWLQJ(ႇHFWV(YDOXDWHGLQ)LVK6KRUW7HUP5HSURGXFWLRQ$VVD\
Kota IRIE (Nissan Chemical Corporation)
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Itaru YAMAMOTO (Safety Science Research Laboratory, Central Research Institute, Ishihara Sangyo Kaisha,
LTD.)

6
10:20 - 10:55

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10:55 - 11:30&XUUHQWDQGIXWXUHHQYLURQPHQWDOULVNDVVHVVPHQWVWXGLHVRISHVWLFLGHVRQ
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Tatsuya SEKINE (ibacon GmbH)
0ROOXVFVLQWR[LFRORJ\WHVWLQJHPSKDVL]LQJVQDLOVKlaus WEBER (AnaPath Services GmbH, Switzerland)
Room 8

Candidates for the Excellent Presentation Award (Oral)

June 30 (Thu) 9:30 - 11:06 Room 8&DQGLGDWHVIRUWKH([FHOOHQW3UHVHQWDWLRQ$ZDUG 2UDO 
Chairs: Yuhji TAQUAHASHI (Division of Cellular and Molecular Toxicology, Center for Biological Safety &Research, National Institute of Health Sciences)

Hideshi TSUSAKI (Shin Nippon Biomedical Laboratories, Ltd.)
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9:30 - 9:36
VXSSRUWQRQFOLQLFDOVWXGLHVTadahaya MIZUNO (Laboratory of Molecular Pharmacokinetics Graduate School of Pharmaceutical Sciences
The University of Tokyo)

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9:36 - 9:42
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Chisato KANEKO (Translational Research Division, Chugai Pharmaceutical Co., Ltd.)e24

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9:48 - 9:54

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6/30 AM$JULFXOWXUDOFKHPLFDOV
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9:42 - 9:48
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Tetsushi HIRANO (Faculty of Pharmaceutical Sciences, University of Toyama)
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Chikage MORI (Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University)
0ROHFXODUPHFKDQLVPIRUDUVHQLWHPHGLDWHGG\VIXQFWLRQRIEORRGFRDJXODWLRQV\VWHPVLQKXPDQYDVFXODUHQGRWKHOLDOFHOOVDQGVPRRWKPXVFOHFHOOVTsuyoshi NAKANO (Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tokyo
University of Science)3(
10:00 - 10:06

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Md. Shiblur RAHAMAN1, 2 (1Department of Environmental and Preventive Medicine, Jichi Medical
2

University, Department of Environmental Science and Disaster Management,
Noakhali Science and Technology University)(QYLURQPHQWDOSROOXWDQWV
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10:06 - 10:12
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Kanami WATANABE (Division of Toxicology, Department of Veterinary Medicine, Kitasato University)3(
10:12 - 10:18

3(
10:18 - 10:24

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10:24 - 10:30

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environmental toxicity
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Raga ISHIKAWA (Graduate School of Engineering, Kyoto University)
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10:30 - 10:36
UDWVE\DQLQWHUPLWWHQWLQWUDWUDFKHDODGPLQLVWUDWLRQAi MAENO (Tokyo Metropolitan Institute of Public Health)Liver3(
10:36 - 10:42

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10:42 - 10:48(OXFLGDWLRQRI6$56&R9LQGXFHGOLYHULQMXU\XVLQJOLYHURQDFKLSVSayaka DEGUCHI (Center for iPS Cell Research and Application (CiRA), Kyoto University)
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Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)e25

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Norifumi TAKIMOTO1, 2 (1Division of Pathology, National Institute of Health Sciences, 2Laboratory of
Veterinary Medicine, Tokyo University of Agriculture and Technology)

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10:54 - 11:00
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Yoko NISHINO (Global Drug Safety, Eisai Co., Ltd.)
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Taiki MIHARA (Department of Veterinary Pharmacology, Graduate School of Agricultural and Life Sciences,
The University of Tokyo)

e26Day 1 PM (June 30 (Thu))
Room 1
Symposium 7

June 30 (Thu) 13:30 - 15:30 Room 1

6/30 PM-673-627-RLQW6\PSRVLXP&DUFLQRJHQLFLW\HYDOXDWLRQLQ
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Chairs: Kumiko OGAWA (National Institute of Health Sciences)
Masami SUZUKI (Central Institute for Experimental Animals),QWURGXFWLRQ
13:30 - 13:36

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Masami SUZUKI (Central Institute for Experimental Animals)
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Toshihisa FUJIWARA (Shin Nippon Biomedical Laboratories, Ltd)6XUYH\RIWXPRULJHQLFVHQVLWLYLW\IRUKLJKGRVHVHOHFWLRQE\H[SRVXUHUDWLRVLQUDV+7JPRXVHFDUFLQRJHQLFLW\VWXGLHV
Shigeru HISADA1, 2 (1Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, The Japan
2

Pharmaceutical Manufacturers Association, ASKA Pharmaceutical Co., Ltd.)&RQFOXVLRQ
15:24 - 15:30

Symposium 8

June 30 (Thu) 15:30 - 17:30 Room 1$VVHVVPHQWIRULQGLYLGXDOVXVFHSWLELOLWLHVWRGUXJRQGUXJVDIHW\UHVHDUFKChair: Tadahiro SHINOZAWA (Global Drug Safety Research and Evaluation, Takeda Pharmaceutical Company)
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Masaru KOIDO1, 2 (1Laboratory of Complex Trait Genomics, Department of Computational Biology andMedical Sciences, Graduate School of Frontier Sciences, The University of Tokyo,
2

Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative

Medical Sciences)6
16:30 - 17:00

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3HUVRQDOL]HGPHGLFDOFDUHIRUSHGLDWULFGUXJWKHUDS\DQGSKDUPDFRJHQRPLFVKeiko HIKINO (RIKEN Center for Integrative Medical Sciences)([SORUDWRU\UHVHDUFKRQUHODWLRQVKLSVEHWZHHQJHQHSRO\PRUSKLVPVDQG
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June 30 (Thu) 13:30 - 15:30 Room 2&\WRNLQHUHOHDVHV\QGURPHVWLOOOLQJHUZLWKDQWLERG\WKHUDS\
Chairs: Kazuhiko MORI (Daiichi Sankyo RD Novare Co., Ltd.)
Ken-ichiro NAN-YA (Toxicological Research Laboratories, Translational Research Unit, R&D Division,
Kyowa Kirin Co., Ltd.)

6/30 PM6
13:30 - 13:40

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13:40 - 14:05

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14:05 - 14:30

6
14:30 - 14:55

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Masayuki MISHIMA (Translational Research Division, Chugai Pharmaceutical)&56LQWKHFOLQLFDOVHWWLQJ
Yasutoshi KUBOKI (Department of Experimental Therapeutics, National Cancer Center Hospital East)
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Yoshika IWATA (Translational Research Division, Chugai Pharmaceutical Co., Ltd.)'LVFXVVLRQ
15:20 - 15:30

Symposium 10

June 30 (Thu) 15:30 - 17:30 Room 2'HYHORSPHQWRIQHZQDQRPDWHULDODVVHVVPHQWPHWKRGRORJLHVIRULQKDODWLRQLPPXQRORJLFDODQGFDUGLRYDVFXODUWR[LFLWLHVChairs: Akihiko HIROSE (National Institute of Health Sciences)
Yuhji TAQUAHASHI (Division of Cellular and Molecular Toxicology, Center for Biological Safety &Research, National Institute of Health Sciences),QWURGXFWLRQ
15:30 - 15:33

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15:33 - 15:57

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Research, National Institute of Health Sciences)6
15:57 - 16:21(YDOXDWLRQRIWKHFDUFLQRJHQLFLW\RIQDQRPDWHULDOVXVLQJWKHLQWUDWUDFKHDOLQVWLOODWLRQPHWKRGLQUDWV5HFHQWGHYHORSPHQWVDQGLVVXHV
Motoki HOJO (Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of
Public Health)6
16:21 - 16:45

6
16:45 - 17:30

e28'HYHORSPHQWRIDQLQYLWURLPPXQRWR[LFLW\DVVD\IRUQDQRPDWHULDOVE\
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Takao ASHIKAGA (Division of Risk Assessment, National Institute of Health Sciences)
1DQR SDUWLFOHH[SRVXUHDFXWHSKDVHUHVSRQVHDQGFDUGLRYDVFXODUGLVHDVH
Ulla VOGEL (National Research Centre for the Working Environment)Room 3
Symposium 11

June 30 (Thu) 13:30 - 15:30 Room 3

Chairs: Toshikazu USHIJIMA (National Cancer Center Research Institute)Jun KANNO (National Institute of Health Sciences),QWURGXFWLRQ
13:30 - 13:34
Toshikazu USHIJIMA (National Cancer Center Research Institute)6
13:34 - 13:58

6
13:58 - 14:22

6
14:22 - 14:46

5HPRGHOLQJRIQRUPDODQGLQÀDPHGHSLWKHOLXP
Seishi OGAWA (Department of Pathology and Tumor Biology, Graduate School of Medicine Kyoto University)(SLJHQRPLFDOWHUDWLRQVLQDFHOOXODUHFRV\VWHPLQUHVSRQVHWRLQWULQVLFDQG
H[WULQVLFIDFWRUV
Naoko HATTORI (Division of Epigenomics, National Cancer Center Research Institute)
0XWDWLRQDOVLJQDWXUHVLQWKHFDQFHUJHQRPHVTatsuhiro SHIBATA (Laboratory of Molecular Medicine, Human Genome Center, The Institute of Medical
Science, The University of Tokyo)

6
14:46 - 15:10

3HUFHOORPHWUDQVFULSWRPLFVDQDO\VLVZLWKHSLJHQHWLFFRQVLGHUDWLRQVRQFDUFLQRJHQVWHVWHGE\WKH³1HZ5HSHDWHG'RVLQJ3URWRFRO´
Jun KANNO (National Institute of Health Sciences, Center for Biological Safety and Research, Division of
Cellular and Molecular Toxicology)'LVFXVVLRQ
15:10 - 15:30

Symposium 12

June 30 (Thu) 15:30 - 17:30 Room 3-6&7-627-RLQW6\PSRVLXP5HFHQWWUHQGVLQEDVLFVWXG\DQGFOLQLFDODSSOLFDWLRQRIWKHFXWWLQJHGJHWHFKQRORJ\IRUYLWDOVLJQPRQLWRULQJ
Chairs: Manabu SUGITA (Juntendo University Nerima Hospital)
Satoshi KITAJIMA (Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research,
National Institute of Health Sciences)6
15:30 - 16:00

6
16:00 - 16:25,W VGUHDPWLPH$SSOLFDWLRQVRIFDUERQQDQRWXEHVWRDGYDQFHGWHFKQRORJ\SURGXFWV
Shuji TSURUOKA1, 2 (1Shinshu University, 2Siddarmark, LLC)
$QDSSURDFKWRSUHGLFWLRQRIPRUWDOLW\LQDFXWHWR[LFLW\VWXGLHVE\LQWHJUDWHG
DVVHVVPHQWRIYLWDOVLJQVYuhji TAQUAHASHI 'LYLVLRQRI&HOOXODUDQG0ROHFXODU7R[LFRORJ\&HQWHUIRU%LRORJLFDO6DIHW\ 
Research, National Institute of Health Sciences)6
16:25 - 16:50

6
16:50 - 17:15

7KHVLJQL¿FDQFHRIPRQLWRULQJWRSUHGLFWXQIRUHVHHQHYHQWVManabu SUGITA (Juntendo University Nerima Hospital)
9LWDO6LJQVDQGV\PSWRPVFKDUDFWHULVWLFRISDWLHQWVZLWKSRLVRQLQJ
Katsura HAYAKAWA (Department of Critical Care Medicine, Toranomon Hospital)e29

6/30 PM-627-&$-RLQW6\PSRVLXP0ROHFXODUEDVLVIRUWKHHYROXWLRQRIWKH
HYDOXDWLRQPHWKRGVRIFDUFLQRJHQLFSRWHQWLDOV'LVFXVVLRQ
17:15 - 17:30

Room 4
Symposium 13

June 30 (Thu) 13:30 - 15:30 Room 4

6/30 PM&XUUHQWVWDWXVDQGSURVSHFWVRIDGYHUVHHYHQWVUHVHDUFKLQKXPDQVXWLOL]LQJFRPSXWHUVFLHQFH
Chairs: Kaori AMBE (Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City
University)

Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of
Shizuoka),QWURGXFWLRQ
13:30 - 13:32

6
13:32 - 14:01

0DFKLQHOHDUQLQJDSSURDFKWRSUHGLFWWKHDGYHUVHGUXJUHDFWLRQLQKXPDQKaori AMBE (Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City
University)

6
14:01 - 14:30(YDOXDWLRQDQGSUHGLFWLRQRIHႇHFWVRIFKHPLFDOVRQKXPDQVXVLQJQHWZRUNELRORJ\
Midori IIDA (Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems
Engineering, Kyushu Institute of Technology)

6
14:30 - 14:59

6
14:59 - 15:28

3UHGLFWLRQRI'UXJ,QGXFHG/LYHU0DOLJQDQW7XPRU%DVHGRQ%LJ'DWD
$QDO\VLVDQG&RPSXWDWLRQDO7R[LFRORJ\
Kota KUROSAKI (Department of Medical Molecular Informatics, Meiji Pharmaceutical University)
6\VWHPDWLF$QDO\VLVRI&OLQLFDO7ULDO'DWDIRU3HUVRQDOL]HG7KHUDS\(ႇHFWV
RI([HUFLVH7UDLQLQJLQ&KURQLF+HDUW)DLOXUH3DWLHQWV'HSHQGRQ
0HGLFDWLRQVDQG&RQGLWLRQV
Yukako SOEJIMA1, 2 (1Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical2

Sciences, Chiba University, 5HJXODWRU\$൵DLUV6DQR¿..-DSDQ&RQFOXVLRQ
15:28 - 15:30

Symposium 14

June 30 (Thu) 15:30 - 17:30 Room 4

1HZDVSHFWVRIWKDOLGRPLGHVWXG\WRZDUGHOXFLGDWLRQRIVSHFLHVGLႇHUHQFH
EDVHGRQPHWDEROLVPChairs: Hiroki TERAOKA (Rakuno Gakuen University)
Hiroshi YAMAZAKI (Showa Pharmaceutical University),QWURGXFWLRQ
15:30 - 15:32
Hiroki TERAOKA (Rakuno Gakuen University)
6
15:32 - 15:55

e30$SULPDU\PHWDEROLWHK\GUR[\WKDOLGRPLGHLQWKHUDEELWDWKDOLGRPLGH
VHQVLWLYHVSHFLHVEXWƍK\GUR[\WKDOLGRPLGHLQQRWVHQVLWLYHUDWV
Hiroshi YAMAZAKI (Showa Pharmaceutical University)

6
15:55 - 16:18'HYHORSPHQWDOWR[LFLW\RIWKDOLGRPLGHLQUDEELWVSRVVLEOHWHUDWRJHQLFHႇHFWVRQPDOHVHPHQ
Makiko KUWAGATA (Division of Cellular and Molecular Toxicology, CBSR, National Institute of Healthand Science)

16:18 - 16:41

6
16:41 - 17:04

8QGHUVWDQGLQJWKH7KDOLGRPLGH&KLUDOLW\LQ%LRORJLFDO3URFHVVHVE\WKH
6HOIGLVSURSRUWLRQDWLRQRI(QDQWLRPHU
Norio SHIBATA (Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology)$OWHUDWLRQVLQQHRVXEVWUDWHVHOHFWLYLW\RIFHUHEORQWKURXJKWKDOLGRPLGH
PHWDEROLVP
Takuya MIYAKAWA1, 2 (1Graduate School of Agricultural and Life Sciences, The University of Tokyo,
26
17:04 - 17:27

6/30 PM6

Graduate School of Biostudies, Kyoto University)$XJPHQWDWLRQRIWKDOLGRPLGHWHUDWRJHQLFLW\LQKXPDQ&<3$VH[SUHVVLQJ]HEUD¿VK
Hiroki TERAOKA (Rakuno Gakuen University)&RQFOXVLRQ
17:27 - 17:30
Hiroshi YAMAZAKI (Showa Pharmaceutical University)
Room 5
Workshop 1

June 30 (Thu) 13:30 - 15:30 Room 5&XUUHQWVWDWXVRILQYLWURUHVHDUFKOHDGLQJGUXJGLVFRYHU\DQGGHYHORSPHQW
VDIHW\UHVHDUFKChairs: Hisaharu YAMADA (LSI Medience Corporation Drug Discovery Support Business Headquarters)
Kazunori FUJIMOTO (Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.),QWURGXFWLRQ
13:30 - 13:40
Hisaharu YAMADA (LSI Medience Corporation Drug Discovery Support Business Headquarters):
13:40 - 14:06([SHULHQFHZRUNLQJZLWK/LYHU0365HVHDUFKRIWKH7H[DV$ 07LVVXH&KLS
9DOLGDWLRQ 7(;9$/ &RQVRUWLXP
Yuki KATO1, 2 (1Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and2%LRPHGLFDO6FLHQFHV7H[DV$ 08QLYHUVLW\&ROOHJH6WDWLRQ7;86$ Laboratory for Drug
'LVFRYHU\DQG'HYHORSPHQW6KLRQRJL &R/WG2VDND-DSDQ:
14:06 - 14:32:
14:32 - 14:58:
14:58 - 15:24$FDVHVWXG\RIPHFKDQLVWLFLQYHVWLJDWLRQXVLQJin vivo DQGin vitro VWXGLHVIRUWR[LFRORJLFDOFKDQJHREVHUYHGLQROLJRQXFOHRWLGHGHYHORSPHQW
Yoshiko OKAI (Takeda Pharmaceutical Company Limited)
6WXG\IRUGUXJLQGXFHGVHL]XUHSUHGLFWLRQXVLQJFXOWXUHGQHXURQVDQG
PLFURHOHFWURGHDUUD\UDWSULPDU\QHXURQVYVUDWLQYLYRPRGHOFOLQLFDOFOLQLFDO
Aoi ODAWARA (Eisai Co., Ltd.)
7KHDSSOLFDWLRQRIKXPDQL36FHOOVWRin vitro WR[LFLW\DVVHVVPHQWLQGUXJUHVHDUFKDQGGHYHORSPHQWLQ&KXJDL
Jumpei KIYOKAWA (Translational Research Division, Chugai Pharmaceutical Co., Ltd.)&RQFOXVLRQ
15:24 - 15:30
Kazunori FUJIMOTO (Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.)e31

Symposium 15

June 30 (Thu) 15:30 - 17:30 Room 5([DPSOHVSURVSHFWVDQGVRFLDOPHDQLQJRI&KURQRWR[LFRORJ\
Chairs: Nobuhiko MIURA (Yokohama University of Pharmacy)
Hiroki YOSHIOKA (Department of Pharmacy, Gifu University of Medical Science)
6\PSRVLXP2XWOLQH
15:30 - 15:35
Nobuhiko MIURA (Yokohama University of Pharmacy)
6/30 PM6
15:35 - 15:55

6
15:55 - 16:25&KURQRWR[LFLW\RIFKHPLFDOLQGXFHGKHSDWLFLQMXU\LQPLFH
Hiroki YOSHIOKA (Department of Pharmacy, Gifu University of Medical Science)
6WUXFWXUHDQG)XQFWLRQRI7KHUPRVHQVLWLYH753FKDQQHOV
Makoto TOMINAGA1, 2 (1Division Cell Signaling, National Institute for Physiological Sciences, 2Thermal
Biology Group, Exploratory Research Center on Life and Living Systems)

6
16:25 - 16:55

6
16:55 - 17:25&DGPLXPWR[LFLW\R[LGDWLYHVWUHVVDQGVOHHSZDNHUK\WKPV
Masayuki IKEDA (Faculty of Science, University of Toyama)
51$HGLWLQJHQ]\PH$'$5UHJXODWHVWKHFLUFDGLDQH[SUHVVLRQRI[HQRELRWLF
WUDQVSRUWHUVLQKXPDQUHQDOSUR[LPDOWXEXODUHSLWKHOLXP
Satoru KOYANAGI1, 2 (1Pharmaceutics, Faculty of Pharmaceutical Sciences, Kyushu University, 2Glocal
Healthcare Science, Faculty of Pharmaceutical Sciences, Kyushu University)

Summary
17:25 - 17:30

Nobuhiko MIURA (Yokohama University of Pharmacy)
Room 6

Symposium 16

June 30 (Thu) 13:30 - 15:00 Room 6*HQHFHOOWKHUDS\GHYHORSPHQWDQGLWVVDIHW\DVVHVVPHQW
Chairs: Akihito SHIMOI (Ina Research Inc & Center for Advanced Research of Gene and Cell Therapy in Shinshu
University)

Toyohiko AOKI (DIMS Institute of Medical Science, Inc.)
6
13:30 - 14:00,QIUDVWUXFWXUHGHYHORSPHQWIRUQRQFOLQLFDOVDIHW\VWXGLHVLQQRQKXPDQSULPDWHVDLPLQJIRUWKHFOLQLFDODSSOLFDWLRQRI-DSDQPDGHJHQHDQGFHOOWKHUDS\
Yozo NAKAZAWA1, 2 (1Department of Pediatrics, Shinshu University School of Medicine, 2Center for
Advanced Research of Gene and Cell Therapy, Shinshu University)

6
14:00 - 14:30/\PSKRGHSOHWHGQRQKXPDQSULPDWHPRGHOIRUWKHDVVHVVPHQWRIDFXWHRQ
WDUJHWDQGRႇWXPRUWR[LFLW\RIKXPDQ&$57FHOOV
Shigeki YAGYU1, 2 (1Center for Advanced Research of Gene and Cell Therapy, Shinshu University,2

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural

University of Medicine)6
14:30 - 15:00

e32&XUUHQW6WDWXVDQG,VVXHVLQ6DIHW\(YDOXDWLRQRI*HQH7KHUDS\'UXJVKoichi MIYAKE (Department of Gene Therapy, Nippon Medical School)

Workshop 2

June 30 (Thu) 15:00 - 16:00 Room 6&OLQLFDODGYHUVHHYHQWVVLGHHႇHFWVWKDWDUHGLႈFXOWWRGHWHFWLQJHQHUDO
WR[LFLW\VWXGLHVQHZDSSURDFKHVIURPQRQFOLQLFDOUHVHDUFK3DUW, *HQHUDOUHPDUNV,QWURGXFWLRQ
15:00 - 15:01:
15:01 - 15:06:
15:06 - 15:36+RZWRHYDOXDWHFOLQLFDODGYHUVHHYHQWVLQQRQFOLQLFDOVWXGLHV1HZVWDJHRIQRQFOLQLFDOVWXGLHV,QWURGXFWLRQ
Tamio FUKUSHIMA 6KLRQRJL&R /WG
:KDWLQYHVWLJDWRUVRIFOLQLFDOWULDOVGHVLUHDERXWQRQFOLQLFDOWULDOGDWD
Yuji KUMAGAI1, 2 (1Clinical Trial Center, Kitasato University Hospital, 2Japan Association of Contract
Institutes for Clinical Pharmacology):
15:36 - 15:59&RQFHSWVDQGDSSURDFKIRUSUHGLFWLQJFOLQLFDOVDIHW\IURPQRQFOLQLFDOVWXG\UHVXOWV
([LVWLQJ*XLGHOLQHVDQG1HZ0RGDOLWLHVHiroshi ONODERA (National Institute of Health Sciences)&RQFOXVLRQ
15:59 - 16:00

Symposium 17

June 30 (Thu) 16:00 - 17:30 Room 6

2YHUYLHZRI%LJ3URMHFWVRQ1HZ$SSURDFKPHWKRGVLQ-DSDQ
Chairs: Hajime KOJIMA (National Institute of Health Sciences)
Takashi YAMADA (Division of Risk Assessment, Center for Biological Safety Research, National Institute of
Health Sciences),QWURGXFWLRQ
16:00 - 16:02

6
16:02 - 16:27

6
16:27 - 16:52

6
16:52 - 17:17

0HDQLQJRI$,6+,363URMHFW%DFNJURXQGRIGHYHORSPHQW,GHDRIGHVLJQ
DQG3HUVSHFWLYH
Kimito FUNATSU (Data Science Center, Nara Institute of Science and Technology)'HYHORSPHQWRISURDUUK\WKPLDULVNDVVHVVPHQWXVLQJKXPDQL36&
WHFKQRORJ\DQGIXWXUHSHUVSHFWLYHVYasunari KANDA (Division of Pharmacology, National Institute of Health Sciences)$FKLHYHPHQWVRI$0('0363URMHFWDQG3URVSHFWVRI036UHVHDUFK
Hitoshi NARAOKA (Division of Technology, Stem Cell Evaluation Technology Research Association)'LVFXVVLRQ
17:17 - 17:27&RQFOXVLRQ
17:27 - 17:30

e33

6/30 PM

Chairs: Izuru MIYAWAKI (Sumitomo Pharma Co., Ltd.)
Ichiro NAESHIRO (Cmic Holdings Co., Ltd.)Room 7
Symposium 18

June 30 (Thu) 13:30 - 15:30 Room 7%LRPHWDOV6SHFLDOW\6HFWLRQ6\PSRVLXP$SSURDFKHVWRHOXFLGDWHWKH
PHFKDQLVPVLQYROYHGLQWKHDUVHQLFWR[LFLW\Chairs: Yasuyuki FUJIWARA (Department of Environmental Health, School of Pharmacy, Tokyo University of
6/30 PM

Pharmacy and Life Sciences)

Gi-Wook HWANG (Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University),QWURGXFWLRQ
13:30 - 13:34

6
13:34 - 14:02

7R[LFPHFKDQLVPVRIDUVHQLWHRQWKHEORRGFRDJXODWLRQ¿EULQRO\WLFV\VWHP
Yasuyuki FUJIWARA (Department of Environmental Health, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences)6
14:02 - 14:30

6
14:30 - 14:58

6
14:58 - 15:26,QYHVWLJDWLRQRIDUVHQLFWR[LFLW\LGHQWL¿HGIURPWKHUHVHDUFKRIDOWHUQDWLYHVSOLFLQJRIDUVHQLF R[LGDWLRQVWDWH PHWK\OWUDQVIHUDVH
Daigo SUMI (Faculty of Pharmaceutical Sciences, Tokushima Bunri University)'1$PHWK\ODWLRQFKDQJHVLQRႇVSULQJVSHUPE\JHVWDWLRQDODUVHQLF
H[SRVXUHDQGWKHLULQKHULWDQFHLQ)HPEU\RV
Keiko NOHARA (Health and Environmental Risk Division, National Institute for Environmental Studies)&DUFLQRJHQLFLW\DQGPHFKDQLVPRIDFWLRQRIDUVHQLF
Hideki WANIBUCHI (Department of Molecular Pathology, Osaka Metropolitan University Graduate Schoolof Medicine)&RQFOXVLRQ
15:26 - 15:30

Workshop 3

June 30 (Thu) 15:30 - 17:30 Room 7

3RLQWVWRFRQVLGHULQVHOHFWLQJDVWDUWLQJGRVHOHYHOIRU¿UVWLQKXPDQFOLQLFDOWULDOVRIQRYHOWKHUDSHXWLFPRGDOLWLHVIURPVDIHW\DQGHႈFDF\SHUVSHFWLYHVChairs: Satoko KAKIUCHI-KIYOTA (Safety Assessment, Genentech)
Keiichiro SATO (Pharmacokinetics and Safety Assessment Dept., Nippon Shinyaku Co., Ltd.)
Satoshi TSUNODA (Pharmaceuticals and Medical Devices Agency),QWURGXFWLRQ
15:30 - 15:35:
15:35 - 16:05:
16:05 - 16:35:
16:35 - 16:50

e34

6DIHW\&RQVLGHUDWLRQVLQ)LUVWLQKXPDQ6WXGLHVRI2OLJRQXFOHRWLGH
7KHUDSHXWLFV$5HJXODWRU\3HUVSHFWLYH
Misaki NAOTA (Pharmaceuticals and Medical Devices Agency, Toxicology)&RQVLGHUDWLRQVRQ7R[LFRORJLFDO(YDOXDWLRQLQWKH'HYHORSPHQWRI1H[W*HQHUDWLRQ$QWLERGLHV$5HJXODWRU\3HUVSHFWLYH
Jihei NISHIMURA (Pharmaceutical and Medical devices Agency),QLWLDOGRVHDW),+FOLQLFDOWULDOLQFDVHRIROLJRQXFOHRWLGHWKHUDSHXWLFVKeiichiro SATO (Pharmacokinetics and Safety Assessment Dept., Nippon Shinyaku Co., Ltd.)

16:50 - 17:00:
17:00 - 17:10:
17:10 - 17:30)LUVWLQKXPDQGRVHVHOHFWLRQVWUDWHJ\RIELVSHFL¿FDQWLERGLHV
Sho AKAI (Chugai pharmaceutical Co., Ltd. Translational Research Division))L+VWDUWLQJGRVHVHOHFWLRQVWUDWHJ\RIDELVSHFL¿FQRQ7FHOOHQJDJHUSatoko KAKIUCHI-KIYOTA (Safety Assessment, Genentech)
6WDUWLQJGRVHLQ¿UVWLQKXPDQFOLQLFDOWULDOVRIYDFFLQHDQH[SHULHQFHIURPP51$YDFFLQH
Shinji SHIMIZU (DAIICHI SANKYO CO., LTD., Quantitative Clinical Pharmacology)

6/30 PM:

Room 8
Candidates for the Excellent Presentation Award (Oral)

June 30 (Thu) 13:30 - 14:18 Room 8&DQGLGDWHVIRUWKH([FHOOHQW3UHVHQWDWLRQ$ZDUG 2UDO 
Chair: Makoto SHIBUTANI (Cooperative Division of Veterinary Sciences, Graduate School of Agriculture, Tokyo
University of Agriculture and Technology)

5HSURGXFWLYHDQGGHYHORSPHQWDOWR[LFRORJ\
3( 6WXG\RQ7HUDWRJHQLFLW\RI&RPSRXQG;,QKLELWLRQRIWKH6RQLF+HGJHKRJ
13:30 - 13:36
3DWKZD\,QGXFHVWKH7HUDWRJHQLFLW\
Riki KAWAMOTO (Safety Research Laboratories, Ono Pharmaceutical Co., Ltd.)
3(
13:36 - 13:42([SRVXUHWRDFHSKDWHGXULQJHDUO\OLIHVWDJHVDOWHUVVH[XDOPDWXUDWLRQDQG
UHSURGXFWLYHV\VWHPVLQPDOHDQGIHPDOHPLFH
Takahiro SASAKI (Laboratory of Animal Reproduction and Development, Graduate School of Agricultural
Science, Tohoku University)3(
13:42 - 13:48

3HGLDWULFGUXJLQÀXHQFHVRQVRFLDOEHKDYLRULQMXYHQLOHUDWV
Atsunori HATTORI /DERUDWRU\IRU'UXJ'LVFRYHU\DQG'HYHORSPHQW6KLRQRJL &2/7'

Genetic toxicology3( ([DPLQDWLRQRIDXWRPDWHGPLFURQXFOHXVREVHUYDWLRQXVLQJ$,EDVHGLPDJH
13:48 - 13:54
DQDO\VLVTakumi NUKAGA (Shiseido Co., Ltd %UDQG9DOXH5 ',QVWLWXWH
Carcinogenicity
3( 7KH(VWDEOLVKPHQWRIWKHQRUPDOGRJEODGGHURUJDQRLGFXOWXUHPRGHO
13:54 - 14:00
HYDOXDWHGWKHFDUFLQRJHQLFWR[LFLW\RIFKHPLFDOVXEVWDQFH
Haru YAMAMOTO1, 2 (1Laboratory of Veterinary Pharmacology, Tokyo University of Agriculture and2Technology, Co., Ltd AIRDEC mini)

Immunotoxicology3( 'HWHUPLQDWLRQRINH\UHVLGXHVLQ05*35;WRHQKDQFHSVHXGRDOOHUJLF
14:00 - 14:06
UHDFWLRQVLQGXFHGE\ÀXRURTXLQRORQHVEri HAMAMURA (Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.)
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14:06 - 14:12

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Mengyue SHEN (University of Occupational and Environmental Health, Japan)
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June 30 (Thu) 16:10 - 17:04 Room 8

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Room 1
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July 1 (Fri) 9:00 - 9:50 Room 1

Chair: Satoshi KITAJIMA (Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research,
National Institute of Health Sciences)(/

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July 1 (Fri) 10:00 - 11:30 Room 1

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Chairs: Yoshiro SAITO (National Institute of Health Sciences)
Mamoru MUTAI (LSIM Safety Institute Corporation),QWURGXFWLRQ
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Mamoru MUTAI (LSIM Safety Institute Corporation)
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Yoshiro SAITO (National Institute of Health Sciences)e37

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Kentato TANEMURA (Laboratory of Animal Reproduction and Development Graduate School of
Agricultural Science Tohoku University),QWURGXFWLRQ
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Kenji J. TSUCHIYA1, 2 (1Hamamatsu University School of Medicine, Research Center for Child Mental2

Development, United Graduate School of Child Development, Osaka University,
Kanazawa University, Hamamatsu University School of Medicine, Chiba University
and University of Fukui)6
10:12 - 10:42

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Room 3
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July 1 (Fri) 9:00 - 9:50 Room 3

Chair: Chiharu TOHYAMA (Emeritus Professor, The University of Tokyo)
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Chiho WATANABE (Graduate School of Tropical Medicine and Global Health, Nagasaki University)

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July 1 (Fri) 9:50 - 11:50 Room 3

5LVNDVVHVVPHQWDQGULVNFRPPXQLFDWLRQUHJDUGLQJWKHDGPLQLVWUDWLRQRIPHGLFLQHVDQGEUHDVWIHHGLQJChairs: Kazuhiro SHIMOMURA (Vaccine Research Laboratories, Daiichi Sankyo Co., Ltd.)
Fumito MIKASHIMA (Pharmaceuticals and Medical Devices Agency),QWURGXFWLRQ
9:50 - 9:54

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7/1 AM

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Naoki ITO1, 2 (1Department of Pediatrics, Teikyo University, 2Japan Drug Information Institute in Pregnancy)'LVFXVVLRQ
11:26 - 11:46&RQFOXVLRQ
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Room 4
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July 1 (Fri) 9:00 - 11:30 Room 4

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Chairs: Kazuto WATANABE (Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee, The Japan
Pharmaceutical Manufacturers Association)

Mutsumi SUZUKI (Kyowa Kirin Co., Ltd. R&D Division, Translational Research Unit, Toxicological ResearchLaboratories),QWURGXFWLRQ
9:00 - 9:05

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Naoyuki SAITO1, 2 (1Drug Evaluation Committee, Japan Pharmaceutical Manufacturers Association, 2Otsuka
Pharmaceutical Factory, Inc.)

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Shigenobu SHIBATA (School of Advanced Science and Engineering, Waseda University)e39

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Shigeharu WAKANA (Department of Animal Experimentation, Foundation for Biomedical Research andInnovation at Kobe)

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Hironari KOYAMA (KAC Co., Ltd.)'LVFXVVLRQ
11:10 - 11:30

Room 5
Symposium 23

July 1 (Fri) 9:00 - 11:30 Room 5

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Chairs: Motohiro NISHIDA (Kyushu University, Graduate School of Pharmaceutical Sciences)
Yasunari KANDA (National Institute of Health Sciences)6
9:00 - 9:25

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Yuri KATO (Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University)'HYHORSPHQWRI6$56&R9LQIHFWLRQPRGHOXVLQJKXPDQL36&WHFKQRORJ\
Yasunari KANDA (Division of Pharmacology, National Institute of Health Sciences)
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Takao INOUE (Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences)
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Shingo IWAMI (Division of Biological Science, Graduate School of Science, Nagoya University)'LVFXVVLRQ
11:25 - 11:30

Room 6
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July 1 (Fri) 9:00 - 11:30 Room 6

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Tsuyoshi NAKANISHI (Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical
University),QWURGXFWLRQ
9:00 - 9:05
Hideko SONE (Yokohama University of Pharmacy)
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Keishi ISHIDA (Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University)

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$K5DQG$WRSLF'HUPDWLWLVTomohiro EDAMITSU (Department of Medical Biochemistry, Graduate School of Medicine, Tohoku
University)

9:55 - 10:25

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Wataru YOSHIOKA (Azabu University)'HYHORSPHQWDOWR[LFLW\RIGLR[LQLQFDUGLRYDVFXODUV\VWHP
Hiroki TERAOKA (Rakuno Gakuen University)
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Yuji MISHINA (University of Michigan School of Dentistry)&RQFOXVLRQ
11:25 - 11:30
Tsuyoshi NAKANISHI (Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical
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Chairs: Hideo FUKUI (Axcelead Drug Discovery Partners, Inc.)
Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)
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Yu FUJITA1, 2 (1Department of Translational Research for Exosomes, The Jikei University School of Medicine,
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Division of Respiratory Medicine, Department of Internal Medicine, The Jikei University Schoolof Medicine)

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July 1 (Fri) 11:00 - 11:48 Room 7

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Chairs: Masafumi NAKAYAMA (Laboratory of Immunology and Microbiology, College of Pharmaceutical Sciences,
Ritsumeikan University)

Kazuya NAGANO (Wakayama Medical University)
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Toshikazu KOIWAI (Department of Biochemistry, Tokyo University of Pharmacy and Life Sciences, Tokyo,
Japan)

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11:12 - 11:24,GHQWL¿FDWLRQRISHUVRQDOFDUHSURGXFWVWRH[DFHUEDWHDOOHUJLHVAkiko HONDA1, 2 (1Grad. Sch. of Global Environ. Studies, Kyoto Univ., 2Grad. Sch. of Eng., Kyoto Univ.)e41

7/1 AM

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Reina HASHIMOTO (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical
Sciences, Tokushima University)

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Kengo TOMITA (Medical Environment Engineering Group, Center for Environmental Engineering, Institute ofTechnology, Shimizu Corporation)

Room 8
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July 1 (Fri) 9:00 - 10:00 Room 8

7/1 AM

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Chairs: Kiyoshi KUSHIMA (Astellas Pharma Inc., Applied Research and Operations)
Kumiko OGAWA (National Institute of Health Sciences)
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7KHHႇHFWRIFDGPLXPRQWKHFHOOXODUOHYHOVRIQHFURSWRVLVUHODWHGIDFWRUVJin-Yong LEE (School of Pharmacy, Aichi Gakuin University)

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5XELFRQLQ6+6<<FHOOVTakamitsu MIYAYAMA (Division of Environmental and Occupational Medicine, Department of Hygiene andPublic Health, School of Medicine, Tokyo Women's Medical University)2
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Kazutoshi IIJIMA (Faculty of Engineering, Yokohama National University)%LRSKDUPDFHXWLFDOV
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Robert W EVANS (Labcorp Drug Development)
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Nihat YUMUSAK (Department of Pathology, Faculty of Veterinary Medicine, Harran University, Sanliurfa,
Turkey)e42Oral Session 3

July 1 (Fri) 10:00 - 11:00 Room 8

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Chairs: Daigo SUMI (Faculty of Pharmaceutical Sciences, Tokushima Bunri University)
Yasuhiro SHINKAI (Faculty of Medicine, University of Tsukuba)
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Hitoshi NAKAMURA (Takeda Pharmaceutical Company Limited)2
10:12 - 10:24

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Aina MUKAI (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences,2
10:24 - 10:36

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Tokushima University))XQFWLRQDOHOXFLGDWLRQRIVXSHUVXO¿GHLQKXPDQKDLU
Takeru HIRAI (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences,
Tokushima University)2
10:36 - 10:48'HYHORSPHQWRIDQRYHOPHWKRGIRUDOEXPLQEDVHGQDQRSDUWLFOHSUHSDUDWLRQXVLQJVXOIRVDOLF\OLFDFLGIRUWKHWUHDWPHQWRIVHSVLVYukina TOTTORI (Department of Pharmacokinetics and Biopharmaceutics, Institute of Biomedical Sciences,
Tokushima University),QÀDPPDWLRQ2
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10:48 - 11:00
ligation or LPS treatment
Atsushi KAWASE (Department of Pharmacy, Faculty of Pharmacy, Kindai University)
Oral Session 4

July 1 (Fri) 11:00 - 12:00 Room 8

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Chairs: Yusuke OKUBO (Division of Cellular and Molecular Toxicology, Biological Safety and Research Center,
National Institute of Health Sciences)

Tetsuro ARAKI (Toxicological Research Laboratories, Translational Research Unit, R&D Division, Kyowa
Kirin Co., Ltd.)$OWHUQDWLYHVWRPDPPDOLDQPRGHOV2$KLJKSUHFLVLRQDQGFRPSUHKHQVLYHKXPDQGHYHORSPHQWDOWR[LFLW\WHVW
11:00 - 11:12
EDVHGRQWKHG\QDPLFVRIVLJQDOGLVUXSWLRQLQKXPDQL36FHOOVYusuke OKUBO (Division of Cellular and Molecular Toxicology, Biological Safety and Research Center,
National Institute of Health Sciences)2
11:12 - 11:24&DUGLDFPLFURSK\VLRORJLFDOV\VWHPIRUGHWHFWLQJGUXJLQGXFHGFRQWUDFWLOH
G\VIXQFWLRQ
Daiju YAMAZAKI (Division of Pharmacology, National Institute of Health Sciences)$QLPDOPRGHO2
%HQH¿FLDOHႇHFWVRIYLWDPLQ(RQUDGLRLRGLQHLQGXFHGJDVWURLQWHVWLQDO
11:24 - 11:36
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Nihat YUMUSAK (Department of Pathology, Faculty of Veterinary Medicine, Harran University, Sanliurfa,
Turkey)e432
11:36 - 11:48/LYHFHOOLPDJLQJRI'1$GDPDJHUHVSRQVHVLQWHUSUHWDWLRQIURPRUJDQRLGVWRZKROHERG\
Kensuke OTSUKA (Biology and Environmental Chemistry Division, Sustainable System Research Laboratory,
Central Research Institute of Electric Power Industry)2
11:48 - 12:00

7/1 AM

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3DWKRORJLFDOFDUGLRYDVFXODUUHPRGHOLQJRFFXUULQJLQWKHF\QRPROJXVPRQNH\DJDLQVWDWULRYHQWULFXODUEORFNFRQGLWLRQFKDUDFWHUL]DWLRQDVDQinvivo SURDUUK\WKPLDPRGHODQLPDO
Hiroko IZUMI-NAKASEKO (Department of Pharmacology, Faculty of Medicine, Toho University)

Day 2 PM (July 1 (Fri))
Room 1
Award Lecture

July 1 (Fri) 14:50 - 16:30 Room 1

7KH-627$ZDUG
Chair: Kumiko OGAWA (National Institute of Health Sciences)$:/
14:50 - 15:30&KURQLFWR[LFLW\FDUFLQRJHQLFLW\DQGXQGHUO\LQJPHFKDQLVPVRIRUJDQLF
DUVHQLFDOV
Hideki WANIBUCHI (Department of Molecular Pathology, Osaka Metropolitan University Graduate Schoolof Medicine)

7KH-627<RXQJ6FLHQWLVW$ZDUG
Chair: Yaichiro KOTAKE (Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)$:/
15:30 - 15:50

3K\VLRORJLFDODFWLRQVRIIDWW\DFLGPHWDEROLWHVSURGXFHGE\
GUXJPHWDEROL]LQJHQ]\PHVRQWKHUHGXFWLRQRIQHXURWR[LFLW\
Ami OGURO (Graduate School of Biomedical and Health Sciences, Hiroshima University)

Chair: Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of
Shizuoka)$:/
15:50 - 16:10

8QGHUVWDQGLQJPHFKDQLVPVIRUQXFOHDUUHFHSWRUPHGLDWHGKHSDWRF\WH
SUROLIHUDWLRQ
Ryota SHIZU (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)

7KH-627<RXQJ6FLHQWLVW$ZDUG
Chair: Yasumitsu OGRA (Graduate School of Pharmaceutical Sciences, Chiba University)$:/
16:10 - 16:30(YDOXDWLRQRISRVWPRUWHPFKDQJHVEHWZHHQEORRGSURWHLQVDQGGUXJVYamagishi YOSHIKAZU (Center for Education and Research in Legal Medicine, Graduate School of
Medicine, Chiba University)

Room 2
Symposium 26

July 1 (Fri) 14:50 - 16:50 Room 2$SSOLFDWLRQRIDGYDQFHGLQYLWURKXPDQL]HGPRGHOIRU'UXJ6DIHW\UHVHDUFKChairs: Tadahiro SHINOZAWA (Global Drug Safety Research and Evaluation, Takeda Pharmaceutical Company)
Norikazu SAIKI (Tokyo Medical and Dental University, Division of Advance Multidisciplinary Research)6
14:50 - 15:20

5HFRQVWUXFWLRQRIKHSDWLFWLVVXHLQYLWUR
Toshihiro MITAKA (Department of Tissue Development and Regeneration, Research Institute for Frontier
Medicine, Sapporo Medical University School of Medicine)6
15:20 - 15:50

2UJDQVSHFLDOL]HGYDVFXODWXUHEHDULQJKXPDQOLYHURUJDQRLGV\VWHPIRUGUXJWR[LFLW\VWXG\
Norikazu SAIKI1, 2 (1Tokyo Medical and Dental University, Division of Advance Multidisciplinary Research,
2

T-CiRA Joint Program)e45

7/1 PM

7KH-627<RXQJ6FLHQWLVW$ZDUG

6
15:50 - 16:20,QYLWURDVVD\VIRUOLYHULQMXU\IURPYLHZSRLQWRIDUHVHDUFKHULQD
SKDUPDFHXWLFDOLQGXVWU\
Yutaka TONOMURA (Pharmacokinetics and Safety Assessment Dept., Discovery Research Labs., Nippon
Shinyaku Co., Ltd.)

6
16:20 - 16:50

7KHDSSOLFDWLRQRIDGYDQFHGOLYHUVSKHURLGDVVD\WRVPDOOPROHFXOHOHDGRSWLPL]DWLRQ&KHPLFDOWR[LFRORJ\SHUVSHFWLYH
Tomoya YUKAWA (Drug safety Research and Evaluation, Chemical Toxicology)
Room 3

Workshop 4

July 1 (Fri) 14:50 - 16:50 Room 3

1RYHOVWUDWHJ\IRUH[SRVRPH
Chairs: Takashi UEHARA (Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, andPharmaceutical Sciences, Okayama University)

Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba),QWURGXFWLRQ
14:50 - 14:55
Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba):
7/1 PM

14:55 - 15:17:
15:17 - 15:39([SRVRPHVSHFLDOL]LQJLQIRRGDGGLWLYHV
Akihiro ITO (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences),PPXQHPHPRU\RIIRRGWKURXJKSURWHLQPRGL¿FDWLRQ
Koji UCHIDA1, 2 (1Graduate School of Agricultural and Life Sciences, The University of Tokyo, 2AMEDCREST):
15:39 - 16:01:
16:01 - 16:23:
16:23 - 16:45'LVFRYHU\RIVPDOOPROHFXOHVWKDWFRQWUROKLVWRQHPRGL¿FDWLRQV
Takayoshi SUZUKI (SANKEN, Osaka University)'HYHORSPHQWRI$ON\QHWDJ7HFKQRORJLHVIRU,GHQWL¿FDWLRQRI3URWHLQ$GGXFWV
Kosuke DODO1, 2 (1RIKEN CPR, 2RIKEN CSRS)
3RWHQWLDO8VHRI,QYHUWHEUDWH0RGHOVLQ([SRVRPH5HVHDUFK
Ryusuke NIWA (Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA),
University of Tsukuba)

Summary
16:45 - 16:50

Takashi UEHARA (Department of Medicinal Pharmacology, Graduate School of Medicine, Dentistry, andPharmaceutical Sciences, Okayama University)

e46

Room 4
Symposium 27

July 1 (Fri) 14:50 - 16:50 Room 4

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1HZ,QWHUVHFWLRQRI)RUHQVLF6FLHQFHDQG7R[LFRORJ\
Chairs: Yuhji TAQUAHASHI (Division of Cellular and Molecular Toxicology, Center for Biological Safety &Research, National Institute of Health Sciences)

Yasuyuki FUJIWARA (Department of Environmental Health, School of Pharmacy, Tokyo University of
Pharmacy and Life Sciences),QWURGXFWLRQ
14:50 - 14:53

14:53 - 15:38

6
15:38 - 16:13

6
16:13 - 16:48)RUHQVLF7R[LFRORJ\LQ-DSDQ
Hirotaro IWASE (Department of Legal Medicine, Faculty of Medicine, Chiba University)'UXJSRLVRQLQJLQIRUHQVLFUDGLRORJ\
Maiko YOSHIDA (Chiba University Center for Education Research in Legal Medicine)
3RVWPRUWHP%UDLQ5HVHDUFKRQ3V\FKLDWULF'LVRUGHUV%HJLQQLQJZLWK)RUHQVLF$XWRSVLHV
Yoichiro TAKAHASHI (Department of Legal Medicine, Faculty of Medicine, University of Tsukuba)

7/1 PM

6

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16:48 - 16:50

Room 5
Workshop 5

July 1 (Fri) 14:50 - 16:50 Room 5/HW VGLVFXVVWKHFXUUHQWVWDWXVDQGFKDOOHQJHVRIQRQFOLQLFDOVDIHW\
DVVHVVPHQWLQWKHHDUO\VWDJHVRIGUXJGHYHORSPHQW
Chairs: Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)
Mutsumi SUZUKI (Kyowa Kirin Co., Ltd. R&D Division, Translational Research Unit, Toxicological ResearchLaboratories),QWURGXFWLRQ
14:50 - 14:51:
14:51 - 15:11:
15:11 - 15:31:
15:31 - 16:06

5HVXOWVRITXHVWLRQQDLUHVXUYH\RQQRQFOLQLFDOWR[LFLW\HYDOXDWLRQLQWKHHDUO\SKDVHRIGHYHORSPHQW
Jun KATAGI (Ono Pharmaceutical Co., Ltd.)3URSRVDOIRU),+IURPSKDUPDFHXWLFDOFRPSDQLHVEDVHGRQWKHUHVXOWVRIDTXHVWLRQQDLUHVXUYH\RQQRQFOLQLFDOWR[LFRORJLFDOHYDOXDWLRQ
Terutaka KODAMA (EA Pharma.Co., Ltd.)
30'$ V3HUVSHFWLYHRQ1RQFOLQLFDO6DIHW\6WXG\,VVXHVLQ(DUO\'HYHORSPHQW
Fumito MIKASHIMA (Pharmaceuticals and Medical Devices Agency)

e47

3DQHO'LVFXVVLRQ
16:06 - 16:49
Izuru MIYAWAKI (Preclinical Research Unit, Sumitomo Pharma Co., Ltd.)
Satoshi TSUNODA (Pharmaceuticals and Medical Devices Agency)&RQFOXVLRQ
16:49 - 16:50

Room 6
Symposium 28

July 1 (Fri) 14:50 - 16:50 Room 6%LRPHWDOV6SHFLDOW\6HFWLRQ6\PSRVLXP)URQWLHUVRIHOHPHQWDODQDO\VLVVXSSRUWLQJWKHUHVHDUFKLQWR[LFRORJ\
Chairs: Yu-ki TANAKA (Graduate School of Pharmaceutical Sciences, Chiba University)
Miyuki IWAI-SHIMADA (Health and Environmental Risk Research Division, National Institute forEnvironmental Studies),QWURGXFWLRQ
14:50 - 14:52

6
7/1 PM

14:52 - 15:21

6
15:21 - 15:50&KHPLFDOIRUPVRIDQWKURSRJHQLFJDGROLQLXPLQULYHUZDWHUSatoki OKABAYASHI (Kwansei Gakuin University)
5HFHQWDGYDQFHVLQ/$,&306IRUHQYLURQPHQWDOKHDOWKVFLHQFH
Miyuki IWAI-SHIMADA (Health and Environmental Risk Research Division, National Institute forEnvironmental Studies)6
15:50 - 16:19

6
16:19 - 16:48(OHPHQWDODQDO\VLVRIDVLQJOHFHOOIRUWKHDSSOLFDWLRQVLQWR[LFRORJ\
Yu-ki TANAKA (Graduate School of Pharmaceutical Sciences, Chiba University)
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Shuji YAMASHITA (School of Science, The University of Tokyo)&RQFOXVLRQ
16:48 - 16:50

Room 7
Symposium 29

July 1 (Fri) 14:50 - 16:50 Room 7

2QWKHIURQWOLQHRI:LOGOLIH7R[LFLW\$VVHVVPHQWE\<RXQJ5HVHDUFKHUVChair: Masafumi KATAYAMA (National Institute for Environmental Studies),QWURGXFWLRQ
14:50 - 14:55

6
14:55 - 15:18*D]LQJDWWKHULVNRIDQWLFRDJXODQWURGHQWLFLGHV $5V DSSOLFDWLRQIURPDTXDWLFELRWD$WWHPSWWRHYDOXDWH$5VWR[LFLW\LQVHDWXUWOHVYoshiya YAMAMURA1, 2 (1Laboratory of Toxicology, Department of Environmental Sciences, Graduate
2

School of Veterinary Medicine, Hokkaido University, The Institute ofEnvironmental Toxicology)e48

6
15:18 - 15:41

6
15:41 - 16:04(VWDEOLVKPHQWRIZLOGOLIHFXOWXUHFHOOZLWKDIHZJHQHVIRUWKHHYDOXDWLRQRI
toxicity
Masafumi KATAYAMA (National Institute for Environmental Studies)&RQVWUXFWLRQRIDPHWKRGIRUSUHGLFWLQJDQLPDOVSHFLHVGLႇHUHQFHVLQ
FKHPLFDOVHQVLWLYLW\IURPKXPDQVLQJOHQXFOHRWLGHSRO\PRUSKLVPVXVLQJ
PROHFXODUVLPXODWLRQ
Kazuki TAKEDA1, 2 (1Laboratory of Toxicology, School of Veterinary Medicine, Kitasato University,2

Department of Computer Science, Tokyo Institute of Technology)

6
16:04 - 16:27$Q$SSURDFKWR([SRVXUHDQG([SRVXUH(ႇHFWV$QDO\VLV8VLQJD+LJK
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Akifumi EGUCHI (Department of Sustainable Health Science, Center for Preventive Medical Sciences, Chiba
University)

6
16:27 - 16:50(YROXWLRQDQGVSHFLHVGLႇHUHQFHVLQ[HQRELRWLFPHWDEROL]LQJHQ]\PHJHQHV
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Yusuke KAWAI (Obihiro University of Agriculture and Veterinary Medicine)

Symposium 30

July 1 (Fri) 14:50 - 16:50 Room 8

5HVHDUFK$SSURDFKHV7RZDUGV$FFXUDWH'HYHORSPHQWDO1HXURWR[LFLW\$VVHVVPHQW
Chairs: Kazuaki NAKAMURA (National Research Institute for Child Health and Development)
Toshihiro ENDO (Phenovance LLC),QWURGXFWLRQ
14:50 - 14:55
Kazuaki NAKAMURA (National Research Institute for Child Health and Development)
6
14:55 - 15:20

6
15:20 - 15:45$XWRPDWHG%HKDYLRUDO$QDO\VLV$SSURDFKIRU)XWXUH'HYHORSPHQWDO
1HXURWR[LFLW\$VVHVVPHQW
Seico BENNER (Department of Psychiatry, Hamamatsu University School of Medicine)'HYHORSPHQWDOQHXURWR[LFLW\DVVHVVPHQWRIHQYLURQPHQWDOFKHPLFDOVXVLQJDQLPDOPRGHO$QDSSOLFDWLRQWRWR[LFLW\WHVWLQJ
Fumihiko MAEKAWA (Health and Environmental Risk Research Division, National Institute forEnvironmental Studies)6
15:45 - 16:10'HYHORSPHQWDOQHXURWR[LFLW\DVVHVVPHQWRIHQYLURQPHQWDOFKHPLFDOVXVLQJDQLPDOPRGHOV7R[LFRORJLFDOHQGRSKHQRW\SHV
Masaki KAKEYAMA1, 2 (1Waseda University Faculty of Human Sciences, 2Research Institute ofEnvironmental Medical Sciences, Waseda University)

S30-4
16:10 - 16:35

in vitro DSSURDFKIRUWKHGHYHORSPHQWDOQHXURWR[LFLW\SRWHQWLDOXVLQJQHXUDOVWHPFHOOIXQFWLRQV
Tomohiro ITO (National Institute for Environmental Studies)'LVFXVVLRQ
16:35 - 16:50

e49

7/1 PM

Room 8

Day 3 AM (July 2 (Sat))
Room 1
Symposium 31

July 2 (Sat) 9:00 - 11:30 Room 1

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Chairs: Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of
Shizuoka)
Hiroshi HONDA (Kao Corporation, R&D Safety Science Research),QWURGXFWLRQ
9:00 - 9:05

6
9:05 - 9:34

6
9:34 - 10:03

6
10:03 - 10:32)XQGDPHQWDOVRI5HDGDFURVVDQGWKH6WDWXVRILWV5HJXODWRU\8VH
Yuki SAKURATANI (Chemicals Management Center, National Institute of Technology and Evaluation)
1H[WJHQHUDWLRQUHDGDFURVVWKDWLQWHJUDWHVPHWKRGVRILQVLOLFRDQGLQYLWUR
Hiroshi HONDA .DR&RUSRUDWLRQ5 '6DIHW\6FLHQFH5HVHDUFK3UHGLFWLRQRIFKHPLFDOWR[LFLW\E\UHDGDFURVVXVLQJFKHPLFDOVWUXFWXUH
information
Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, Universityof Shizuoka)

6
10:32 - 11:01,QYHVWLJDWLRQRIPDWKHPDWLFDOVFLHQFHLVVXHVIRUFRQGXFWLQJUHDGDFURVV
Jun-ichi TAKESHITA (Research Institute of Science for Safety and Sustainability, National Institute ofAdvanced Industrial Science and Technology (AIST))

7/2 AM

6
11:01 - 11:30

3UHGLFWLQJSKDUPDFRORJLFDOHႇHFWVRIFKHPLFDOVEDVHGRQWKHLQWHUDFWLRQVZLWKDOOKXPDQSURWHLQVYoshihiro YAMANISHI (Department of Bioscience and Bioinformatics, Faculty of Computer Science andSystems Engineering, Kyushu Institute of Technology)

Room 2
Educational Lecture 3

July 2 (Sat) 9:00 - 9:50 Room 2

Chair: Hisaharu YAMADA (LSI Medience Corporation Drug Discovery Support Business Headquarters)(/'HVWUXFWLYHLQQRYDWLRQRIYDFFLQH5 'XQGHU&29,'SDQGHPLF
Ken J ISHII1, 2, 3 (1Division of Vaccine Science, The Institute of Medical Science, The University of Tokyo,
2

International Vaccine Design Center, The Institute of Medical Science, The University
3of Tokyo, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical
Innovation, Health and Nutrition)e50

Symposium 32

July 2 (Sat) 9:50 - 11:50 Room 2$QHZDSSURDFKWRQRQFOLQLFDOVDIHW\DVVHVVPHQWRIELRSKDUPDFHXWLFDOVChairs: Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)
Kiyoshi KINOSHITA (Japan Pharmaceutical Manufacturers Association, Drug Evaluation Committee, NonClinical Evaluation Expert Committee),QWURGXFWLRQ
9:50 - 9:52

6
9:52 - 10:17

6
10:17 - 10:42&XUUHQWSUREOHPVIRUWR[LFRORJLFDODVVHVVPHQWLQELRSKDUPDFHXWLFDOVGHYHORSPHQWEDVHGRQDFWXDOFDVHV
Masaki HONDA (Chugai Pharmaceutical Co., Ltd.)6WDWXVDQGFKDOOHQJHVRIQRQFOLQLFDOVDIHW\DVVHVVPHQWRIELRSKDUPDFHXWLFDOV7ZRVXUYH\UHVXOWVZLWKDERXW\HDULQWHUYDOKiyoshi KINOSHITA1, 2 (1Japan Pharmaceutical Manufacturers Association, Drug Evaluation Committee,
2

Non-Clinical Evaluation Expert Committee, MSD K.K., Japan Development,
5HJXODWRU\$൵DLUV$UHD

6
10:42 - 11:07

6
11:07 - 11:32

6XUYH\UHVXOWVIURPDFURVVLQGXVWU\VXSSRUWDQGLQIRUPDQ,&+64 $
SURSRVDO
Rachel B GOLDSMITH -DQVVHQ5HVHDUFK 'HYHORSPHQW&XUUHQW6WDWXVDQG,VVXHVRI1RQFOLQLFDO6DIHW\(YDOXDWLRQRI%LRSKDUPDFHXWLFDOVDW30'$
Kazushige MAKI (Pharmaceuticals and Medical Devices Agency)'LVFXVVLRQ
7/2 AM

11:32 - 11:48&RQFOXVLRQ
11:48 - 11:50

Room 3
Symposium 33

July 2 (Sat) 9:00 - 11:00 Room 3627-627-RLQW6\PSRVLXP/DWHVWLQVLJKWLQWRPHWDOWR[LFLW\DWWKH
molecular level
Chairs: Akihiko HIROSE (National Institute of Health Sciences)
Michael ASCHNER (Albert Einstein College of Medicine, Department of Molecular Pharmacology),QWURGXFWLRQ
9:00 - 9:02

6
9:02 - 9:31

6
9:31 - 10:00

6
10:00 - 10:29

0DQJDQHVH,QGXFHG1HXURWR[LFLW\0HFKDQLVWLF8SGDWH
Michael ASCHNER (Albert Einstein College of Medicine, Department of Molecular Pharmacology)&HOOXODUDQGPROHFXODULQVLJKWVLQWRWKHPHFKDQLVPVRIODWHQWDQGSHUVLVWHQW
methylmercury neurotoxicity
Aaron B BOWMAN (School of Health Sciences, Purdue University)
6LWHVSHFL¿FQHXUDOK\SHUDFWLYLW\YLDWKHDFWLYDWLRQRI0$3.DQG3.$&5(%SDWKZD\VWULJJHUVQHXURQDOGHJHQHUDWLRQLQPHWK\OPHUFXU\LQWR[LFDWHGPLFH
Masatake FUJIMURA (National Institute for Minamata Disease)e51

6
10:29 - 10:58

3K\WRFKHPLFDOVUHSUHVVLQJPHWK\OPHUFXU\WR[LFLW\
Yoshito KUMAGAI (Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)&RQFOXVLRQ
10:58 - 11:00

Oral Session 5

July 2 (Sat) 11:00 - 11:48 Room 3

2UDO6HVVLRQ
Chairs: Tsuyoshi NAKANISHI (Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical
University)

Yoshinori IKENAKA (Hokkaido University)
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,PSDFWRI%HQ]R>D@S\UHQHH[SRVXUHRQ&HQWUDO1HUYRXV6\VWHPRI0LFH
11:00 - 11:12
Walaa SH. ABD EL NABY1, 2 (1Occupational and Environmental Health, Department of Pharmaceutical2

Sciences, Tokyo University of Science, Genetics and Genetic Engineering,
Department of Animal Husbandry and Animal Wealth Development, Facultyof Veterinary Medicine, Alexandria University, Egypt)2
11:12 - 11:24

2
11:24 - 11:36

7/2 AM2
11:36 - 11:48(ႇHFWRIPLQRF\FOLQHRQSDWKRORJLFDOSURJUHVVLRQLQWKHLQIDUFWEUDLQRIWKH
SKRWRWKURPERVLVPRXVHPRGHOMari KONDO (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University)
0HFKDQLVPVUHJXODWLQJDVWURF\WHUHDFWLYLW\LQWKHFHUHEUDOFRUWH[H[SRVHGWRIHWDODOFRKROVSHFWUXPGLVRUGHUVHiroshi HASEGAWA (Laboratory of Hygienic Sciences, Kobe Pharmaceutical University)&KDQJHVLQHQWHULFFHOOXODUHQYLURQPHQWRIWKHSDUNLQVRQLDQPLFHLQGXFHGE\FKURQLFVXEFXWDQHRXVDGPLQLVWHUDWLRQZLWKORZGRVHURWHQRQH
Masato ASANUMA (Department of Medical Neurobiology, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences)

Room 4
Symposium 34

July 2 (Sat) 9:00 - 11:00 Room 4

8VHIXOQHVVRI'FXOWXUHPRGHORI537(&DLPLQJWRSUHGLFWUHQDO
SKDUPDFRNLQHWLFVDQGWR[LFLW\Chairs: Miki NAKAJIMA (Faculty of Pharmaceutical Sciences, Kanazawa University)
Ikumi TAMAI (Faculty of Pharmaceutical Sciences, Kanazawa University),QWURGXFWLRQ
9:00 - 9:03

6
9:03 - 9:29

6
9:29 - 9:55

6
9:55 - 10:21&KDUDFWHUL]DWLRQRI'537(&DVLPSURYHGLQYLWURKXPDQSUR[LPDOWXEXODUFHOOV\VWHP
Naoki ISHIGURO (Nippon Boehringer Ingelheim Co., Ltd.)
8WLOLW\RI'537(&LQHYDOXDWLRQRIUHQDOGUXJPHWDEROLVPMiki NAKAJIMA (Faculty of Pharmaceutical Sciences, Kanazawa University)
8QFRYHUWUDQVSRUWHUPHGLDWHGGUXJLQGXFHGNLGQH\LQMXU\
Hiroshi ARAKAWA (Faculty of Pharmaceutical Sciences, Institute of Medical, Pharmaceutical and Health
Sciences, Kanazawa University)e52

6
10:21 - 10:47'HYHORSPHQWRI'FXOWXUHPRGHOXVLQJKXPDQUHQDOSUR[LPDOWXEXOHFHOOVDQGLWVDSSOLFDWLRQWRGUXJGLVFRYHU\DQGGHYHORSPHQW
Etsushi TAKAHASHI (Nikkiso Co., Ltd.)'LVFXVVLRQ
10:47 - 10:59&RQFOXVLRQ
10:59 - 11:00

Oral Session 6

July 2 (Sat) 11:00 - 11:48 Room 4

2UDO6HVVLRQ
Chairs: Kei NOMIYAMA (Center for Marine Environmental Studies (CMES), Ehime University)
Shouta NAKAYAMA (Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University),QGXVWULDOFKHPLFDOV
2
0HWDERORPLFVEDVHGVHDUFKIRUPDUNHUVDVVRFLDWHGZLWKOXQJGDPDJH
11:00 - 11:12
FDXVHGE\WR[LFSDUWLFXODWHPDWWHUV
Tomoki TAKEDA (Japan Organization of Occupational Health and Safety, Japan Bioassay Research Center)2
11:24 - 11:36

6XVFHSWLELOLW\WHVWWRDQWLFRDJXODQWURGHQWLFLGHVLQVSHFLHVHQGHPLFWRWKH
2JDVDZDUD,VODQGV
Masashi KOIDE (Laboratory of Toxicology, Faculty of Veterinary Medicine, Hokkaido University)$JULFXOWXUDOFKHPLFDOV
2
&KDUDFWHULVWLFVRIPHWDEROLVPWRZDUGVDFHWDPLSULGRQPXVNVKUHZ
11:36 - 11:48
6XQFXVPXULQXVSo SHINYA (Laboratory of Toxicology, Veterinary Medicine, Hokkaido University)
Room 5
Symposium 35

July 2 (Sat) 9:00 - 11:50 Room 5

3RWHQWLDORIVPDOO¿VK ]HEUD¿VKDQGPHGDND DVQH[WJHQHUDWLRQH[SHULPHQWDODQLPDOVDQHZSOD\HULQWR[LFRORJ\
Chairs: Izuru MIYAWAKI (Sumitomo Pharma Co., Ltd.)
Hajime KOJIMA (National Institute of Health Sciences),QWURGXFWLRQ
9:00 - 9:02

6
9:02 - 9:27

6
9:27 - 9:52

3UDFWLFDOLW\RI=HEUD¿VKDVVD\LQ,&+6UHJXODWLRQ
Shin-ichi SEKIZAWA (Department of Pathophysiology and Animal Health, The University of Tokyo)
6WXG\RISKDUPDFRNLQHWLFSURSHUWLHVLQ]HEUD¿VKWRZDUGKLJKO\DFFXUDWH
VDIHW\DVVHVVPHQW
Tasuku NAWAJI (Chemicals Evaluation and Research Institute, Japan (CERI) )e53

7/2 AM(QYLURQPHQWDOSROOXWDQWV2
(ႇHFWVRIGLR[LQLQGXFHGORZSURODFWLQOHYHOVRQEUHDVWPLONVHFUHWLRQGXULQJ
11:12 - 11:24
lactation
Ming YUAN (Graduate School of Pharmaceutical Sciences, Kyushu University)

6
9:52 - 10:17

6
10:17 - 10:37

6
10:37 - 11:02

6
11:02 - 11:27&DUFLQRJHQHVLVLQPHGDND
Satoshi FURUKAWA (Biological Research Laboratories, Nissan Chemical Corporation)
7KHSRWHQWLDOIRUWR[LFLW\DVVD\RIROLJRQXFOHRWLGHWKHUDSHXWLFVZLWK]HEUD¿VK
Tomomi KAKUTANI (Preclinical Research Unit, Sumitomo Pharma Co., Ltd.)
1HZWUHQGVDQGXSGDWHGDYDLODELOLW\IRU=HEUD¿VKVWXGLHVLQ(8DQG86
LQFOXGLQJFOLQLFDOWULDOVUHVXOWLQJIURP]HEUD¿VKEDVHGGUXJGLVFRYHU\
VFUHHQLQJSLSHOLQHV
Vincenzo DI DONATO (ZeClinics SL)+LJK&RQWHQW)XQFWLRQDO6FUHHQLQJIRU2QFRFDUGLRORJ\8VLQJ1RYHO7UDQVOXFHQW&DUGLDF)OXRUHVFHQW3URWHLQ7UDQVJHQLF=HEUD¿VKHV
Toshio TANAKA1, 2 (1Department of Systems Pharmacology, Mie University Graduate School of Medicine,2

Japan, 0LH8QLYHUVLW\0HGLFDO=HEUD¿VK5HVHDUFK&HQWHU-DSDQ

6
11:27 - 11:49

6WXGLHVRQQHXURVFLHQFHDQGGLVHDVHPRGHOVXVLQJ]HEUD¿VK
Koichi KAWAKAMI (Laboratory of Molecular and Developmental Biology, National Institute of Genetics)&RQFOXVLRQ
11:49 - 11:50

Room 6
Symposium 36

July 2 (Sat) 9:00 - 10:30 Room 6(YDOXDWLRQRIKHDOWKLPSDFWDQGGHYHORSPHQWRITXDOLW\DVVHVVPHQWPHWKRGVRIIRRGVDQGIRRGDGGLWLYHVWRZDUGHQVXULQJIRRGVDIHW\
7/2 AM

Chairs: Kazuma HIGASHISAKA (Laboratory of Toxicology and Safety Science, Graduate School of
Pharmaceutical Sciences, Osaka University)(SchoolofPharmaceutical Science, Wakayama Medical University)
Kazuya NAGANO,QWURGXFWLRQ
9:00 - 9:04
Kazuma HIGASHISAKA (Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical
Sciences, Osaka University)

6
9:04 - 9:24

6DIHW\DQDO\VLVRIQDQRPDWHULDOLQIRRG(YDOXDWLRQRIWKHHႇHFWRQFUDQLDOQHUYHIXQFWLRQWRZDUGWKHGHYHORSPHQWRIVDIHIRUPVRIQDQRPDWHULDO
Kazuma HIGASHISAKA1, 2 (1Laboratory of Toxicology and Safety Science, Graduate School of2

Pharmaceutical Sciences, Osaka University, Institute for Advanced CoCreation Studies, Osaka University)

6
9:24 - 9:46

6
9:46 - 10:08

6
10:08 - 10:28(VWLPDWLQJH[SRVXUHDQGULVNDVVHVVPHQWRIFKHPLFDOVIURPIRRGVEDVHGRQWRWDOGLHWVWXG\
Yoshinari SUZUKI (National Institute of Health Sciences)
0$/',06LPDJLQJIRUWKHHYDOXDWLRQRIELRDYDLODELOLW\RIRUDOO\LQJHVWHGFRPSRXQGVMitsuru TANAKA (Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University)&RQVWUXFWLRQDQGHYDOXDWLRQRIDQRYHOVWUDWHJ\RIGHYHORSLQJPROHFXODUO\WDUJHWHGIXQFWLRQDOIRRGVZLWKDZLGHVDIHW\]RQHV
Kazuya NAGANO1, 2 (1School of Pharmaceutical Science, Wakayama Medical University, 2Graduate Schoolof Pharmaceutical Science, Osaka University)

e54

&RQFOXVLRQ
10:28 - 10:30
Kazuya NAGANO (School of Pharmaceutical Science, Wakayama Medical University)
Oral Session 7

July 2 (Sat) 10:30 - 11:30 Room 6

2UDO6HVVLRQ
Chairs: Hiroki TERAOKA (Rakuno Gakuen University)
Seigo SANOH (1School of Pharmaceutical Sciences, Wakayama Medical University, 2Graduate School of
Biomedical and Health Sciences, Hiroshima University)(SLGHPLRORJ\
2
$VVRFLDWLRQEHWZHHQHQYLURQPHQWDOFKHPLFDOVXEVWDQFHVDQGVH[KRUPRQHV
10:30 - 10:42
LQDGXOWPDOHVTakumi KAGAWA1, 2 (1Department of Occupational and Environmental Health, Nagoya University Graduate
2

School of Medicine, Japan, Convolution of Informatics and Biomedical Sciences On
Glocal Alliances, CIBoG, WISE Program, Nagoya University)

2:LWKGUDZDO

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2
(OHFWULFDODFWLYLW\LPDJLQJZLWKKLJKVSDWLRWHPSRUDOUHVROXWLRQLQEUDLQ
10:42 - 10:54
VOLFHVEUDLQRUJDQRLGVDQGFXOWXUHGQHXUDOQHWZRUNV
Ikuro SUZUKI (Department of Electronics, Tohoku Institute of Technology)
10:54 - 11:06,PSULQWHG'05VDUHPDLQWDLQHGLQFRORQGHULYHGRUJDQRLGVMie NARUSE (Central Animal Division, National Cancer Center Research Institute)$23 DGYHUVHRXWFRPHSDWKZD\2'HYHORSPHQWRI$GYHUVH2XWFRPH3DWKZD\UHODWHGWRWUHDWPHQWUHVLVWDQW
11:06 - 11:18
JDVWULFFDQFHU
Shihori TANABE (Division of Risk Assessment, Center for Biological Safety and Research, National Instituteof Health Sciences)'UXJPHWDEROL]LQJHQ]\PH
2
)XQFWLRQDODQDO\VLVRIPDPPDOLDQ8'3JOXFXURQRV\OWUDQVIHUDVHIDPLO\$
11:18 - 11:30
LVRIRUPV 8*7$DQG$ XVLQJEXGGLQJ\HDVWH[SUHVVLRQV\VWHP
Shinichi IKUSHIRO (Faculty of Engineering, Toyama Prefectural University)e55

7/2 AM2

Room 7
Symposium 37

July 2 (Sat) 9:00 - 11:00 Room 7

0DOHUHSURGXFWLYHWR[LFLW\XSWRGDWH
Chairs: Satoshi YOKOTA (Division of Cellular & Molecular Toxicology, Center for Biological Safety & Research,
National Institute of Health Sciences)

Nobuhiko MIURA (Yokohama University of Pharmacy),QWURGXFWLRQ
9:00 - 9:05
Nobuhiko MIURA (Yokohama University of Pharmacy)
6
9:05 - 9:20

6
9:20 - 9:40

7HVWLFXODUG\VIXQFWLRQFDXVHGE\FLUFDGLDQUK\WKPGLVWXUEDQFH
Nobuhiko MIURA (Yokohama University of Pharmacy)(ႇHFWVRIVWUHVVLQHDUO\OLIHVWDJHVRQWKHPDOHUHSURGXFWLYHV\VWHPDQG
next generation
Hidenobu MIYASO (Department of Anatomy, School of Medicine, International University of Health andWelfare)6
9:40 - 10:00

6
10:00 - 10:20

6
10:20 - 10:40(ႇHFWVRI([SRVXUHWR+HDW1RW%XUQ7REDFFRRQ0DOH5HSURGXFWLYH
Function in Mice
Seiichi YOSHIDA (Department of Health and Sciences, Oita University of Nursing and Health Sciences),QYLWURVSHUPDWRJHQHVLVIRUWR[LFLW\WHVWLQJ
Takehiko OGAWA (Yokohama City University)
0DPPDOLDQVSHUPPRWLOLW\
Masakatsu FUJINOKI (Research Lab. of Laboratory Animals, Research Center for Laboratory Animals,

7/2 AM

Comprehensive Research Facilities for Advanced Medical Science, School of
Medicine, Dokkyo Medical University)

6
10:40 - 10:55'HYHORSPHQWRIDQRYHOVWDLQLQJWHFKQLTXHIRUHYDOXDWLQJVSHUPTXDOLW\
Satoshi YOKOTA 'LYLVLRQRI&HOOXODU 0ROHFXODU7R[LFRORJ\&HQWHUIRU%LRORJLFDO6DIHW\ 5HVHDUFKNational Institute of Health Sciences)

Summary
10:55 - 11:00

Satoshi YOKOTA 'LYLVLRQRI&HOOXODU 0ROHFXODU7R[LFRORJ\&HQWHUIRU%LRORJLFDO6DIHW\ 5HVHDUFKNational Institute of Health Sciences)

Oral Session 8

July 2 (Sat) 11:00 - 11:48 Room 7

2UDO6HVVLRQ
Chairs: Kyohei NISHIMURA (1Shionogi Co., Ltd., 2KT2 Task Force, Non-clinical Evaluation Expert Committee,
Japan Pharmaceuticals Manufacturers Association)

Fumiyo SAITO (Department of Toxicology, Division of Veterinary Medicine, Faculty of Veterinary Medicine,
Okayama University of Science)

General toxicology
2
(ႇHFWVLQL36&GHULYHGFDUGLRP\RF\WHEDVHGSKDUPDFRORJLFDOUHVSRQVH
11:00 - 11:12
XVLQJKLJKO\R[\JHQSHUPHDEOHSODWHV
Kentaro ISHIDA (Myoridge Co., Ltd.)e56

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2
%URPHODLQSUHYHQWHGQLFNHOLQGXFHGWHVWLFXODUWR[LFLW\YLDVXSSUHVVLRQRI
11:12 - 11:24
VSHUP'1$IUDJPHQWDWLRQDQGVSHUPTXDOLW\DOWHUDWLRQVLQUDWV
Cigdem CEBI SEN +DUUDQ8QLYHUVLW\'HSDUWPHQWRI5HSURGXFWLRQDQG$UWL¿FLDO,QVHPLQDWLRQ
2
11:24 - 11:36

2
11:36 - 11:48)HDVLELOLW\DQGUHOLDELOLW\RIDGRZQVL]HGFRPSDUDWLYHWK\URLGDVVD\IRU
HYDOXDWLQJWK\URLGKRUPRQHGLVUXSWLQJDFWLYLW\LQPDWHUQDOUDWVDQGWKHLU
RႇVSULQJUHSURGXFLELOLW\VWXG\ZLWKVRGLXPSKHQREDUELWDO
Hidenori SUTO (Sumitomo Chemical Company, Ltd.)
3UHQDWDOVRFLDOGHIHDWVWUHVVH[SRVXUHLQGXFHVGHYHORSPHQWDOGLVRUGHUOLNHEHKDYLRUDODEQRUPDOLWLHV
Munekazu KOMADA (Department of Life Science, Faculty of Science and Engineering, Kindai University)
Room 8

Symposium 38

July 2 (Sat) 9:00 - 11:00 Room 8

5HFHQWGUXJDSSOLFDWLRQDQGWR[LFLW\HYDOXDWLRQLQWKHH\HV
Chairs: Akinobu OKADA (Applied Research & Operations, Astellas Pharma Inc.)
Hideshi TSUSAKI (Shin Nippon Biomedical Labs (SNBL), Ltd)
6
9:00 - 9:24

6
9:24 - 9:48

&RPSDUDWLYHRSKWKDOPRORJ\LQODERUDWRU\DQLPDOVLQ'UXJWR[LFLW\HYDOXDWLRQ
Hiroki TSUJITA (Veterinary Ophthalmology Specialized Clinic)
3DWKRSK\VLRORJLFDODQDO\VLVDQGUHVHDUFKIRUGUXJGLVFRYHU\XVLQJH[SHULPHQWDOUHWLQDOGLVHDVHPRGHOVMasamitsu SHIMAZAWA (Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu

6
9:48 - 10:12

6
10:12 - 10:36

6
10:36 - 11:00(PSOR\PHQWRILQWUDYLWUHDODQGVXEUHWLQDODGPLQLVWUDWLRQWHFKQLTXHVIRUQHZ
PRGDOLW\GUXJVDQGRFXODUWR[LFLW\HYDOXDWLRQ
Tomoaki ARAKI (Shin Nippon Biomedical Laboratories Ltd. Drug Safety Research Laboratories)
3RLQWVWRFRQVLGHUIRURFXODUWR[LFLW\HYDOXDWLRQLQQRQFOLQLFDOVWXG\
Takeshi SATO (Astellas Pharma Inc.)$FDVHVWXG\RIRFXODUWR[LFLW\FDXVHGE\LPSXULWLHVGXULQJGUXJGHYHORSPHQW
Kazuhiro HOSOI 7R[LFRORJ\DQG3KDUPDFRNLQHWLFV*URXS3KDUPDFHXWLFV 3KDUPDFRORJ\'HSDUWPHQW
Product Development Division, Santen Pharmaceutical Co., Ltd.)

Oral Session 9

July 2 (Sat) 11:00 - 11:48 Room 8

2UDO6HVVLRQ
Chairs: Akira KUBOTA (Department of Veterinary Medicine, Obihiro University of Agriculture and Veterinary Medicine)
Hazuki MIZUKAWA (Ehime University)&HOOXODUUHVSRQVH
2
([SRUWRIH[FHVVUHDFWLYHVXOIXUVSHFLHVWKURXJKF\VWLQHGHSHQGHQW
11:00 - 11:12
DQWLSRUWHUVHanako AOKI (Degree Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences,
University of Tsukuba)e57

7/2 AM

Pharmaceutical University)

2
11:12 - 11:24'HYHORSPHQWRIVLJQDOSDWKZD\DQDO\VLVPHWKRGXWLOL]LQJLQWUDFHOOXODUORFDOL]DWLRQLQIRUPDWLRQRISURWHLQ
Nobuhiko MAIYA (NIKON CORPORATION)(SLJHQHWLFV2
(YDOXDWLRQRIWR[LFLW\E\PRQLWRULQJFI'1$
11:24 - 11:36
Ryuichi ONO (Division of Cellular and Molecular Toxicology, Center for Biological Safety and Research (CBSR),
National Institute of Health Sciences (NIHS))%LRPDUNHUV2
(ႇHFWRIOLJKWGDUNF\FOHRQFOLQLFDOFKHPLVWU\YDOXHVLQPDOH5DWV)HGDKLJK
11:36 - 11:48
IUXFWRVHGLHW
Yusuke SUZUKI1, 2 (1Toxicology Research Laboratories Central Pharmaceutical Research Institute Japan2

Tobacco Inc., University of Miyazaki Interdisciplinary Graduate School of Agriculture
and Engineering)

7/2 AM

e58

Day 3 PM (July 2 (Sat))
Room 1
Symposium 39

July 2 (Sat) 14:00 - 16:30 Room 1,PPXQRWR[LFLW\RIFKHPLFDOVXEVWDQFHVPHFKDQLVPHOXFLGDWLRQDQGLWV
SUHYHQWLRQChairs: Yasuo YOSHIOKA (Institute for Open and Transdisciplinary Research Initiatives, Osaka University)
Masafumi NAKAYAMA (Laboratory of Immunology and Microbiology, College of Pharmaceutical Sciences,
Ritsumeikan University),QWURGXFWLRQ
14:00 - 14:05

6
14:05 - 14:33

0DFURSKDJH5HFRJQLWLRQRI&DUERQ1DQRWXEHV
Masafumi NAKAYAMA1, 2 (1Laboratory of Immunology and Microbiology, College of Pharmaceutical2

Sciences, Ritsumeikan University, CREST, JST)6
14:33 - 15:01

6
15:01 - 15:29

6
15:29 - 15:57$QWLLQÀDPPDWRU\DQGLPPXQHIXQFWLRQVRIWKH[HQRELRWLFUHVSRQVLYH
QXFOHDUUHFHSWRU3;5
Ryota SHIZU (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizuoka)
3HUWXUEDWLRQRI,/$UHVSRQVHE\HQYLURQPHQWDOFKHPLFDOVRyuta MUROMOTO (Faculty of Pharmaceutical Sciences, Hokkaido University),QÀXHQFHRIORZGRVHFKHPLFDOH[SRVXUHRQWKHGHYHORSPHQWRIDOOHUJLFGLVHDVHVTomoki FUKUYAMA (Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu
University)

6
15:57 - 16:25,PPXQRORJLFDODSSURDFKHVWRWKHSDWKRJHQHWLFFRQWURORILQÀDPPDWRU\ERZHOGLVHDVH
Atsuhito KUBOTA1, 2 (1School of Pharmaceutical Sciences, Health Sciences University of Hokkaido,2

Department of Pharmacy, Hokkaido University Hospital)

7/2 PM&RQFOXVLRQ
16:25 - 16:30

Room 2
Symposium 40

July 2 (Sat) 14:00 - 16:00 Room 2

7RZDUGIXUWKHUSURJUHVVRI5VLQDQLPDOH[SHULPHQWV
Chairs: Hiroaki TODO (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)
Kousei ITO (Graduate School of Pharmaceutical Sciences, Chiba University),QWURGXFWLRQ
14:00 - 14:05

6
14:05 - 14:29,QWHUQDWLRQDOWUHQGVIRU5VRIDQLPDOH[SHULPHQWV
Hajime KOJIMA (Japanese Center for the Validation of Alternative Methods, National Institute of Health
Sciences)e596
14:29 - 14:53$FWLYLWLHV7KH-DSDQHVH6RFLHW\IRU$OWHUQDWLYHVWR$QLPDO([SHULPHQWVKDV
GRQHDQGLWVLVVXHV
Masaharu AKITA (Faculty of Family and Consumer Science, Department of Nutrition and Dietetics, Kamakura
Women's University)

6
14:53 - 15:17'HYHORSPHQWRIDFRPSXWDWLRQDOWR[LFRORJ\V\VWHPWKDWUHDOL]HVWR[LFLW\SUHGLFWLRQEDVHGRQWKHPHFKDQLVPRIWR[LFLW\
Hiroshi YAMADA (Toxicogenomics Informatics Project, National Institutes of Biomedical Innovation, Healthand Nutrition)

6
15:17 - 15:41

6
15:41 - 16:00$SSURDFKHVDQGFKDOOHQJHVRIWKH5VSULQFLSOHLQDVVHVVLQJUHSURGXFWLYH
WR[LFLW\WRKLJKHUSUHGDWRUV ELUGVTakaharu KAWASHIMA (National Institute for Environmental Studies))XWXUHDFWLRQSODQRIWKH-DSDQHVH6RFLHW\IRU$OWHUQDWLYHVWR$QLPDO([SHULPHQWV
Hiroaki TODO (Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)
Room 3

Symposium 41

July 2 (Sat) 14:00 - 16:30 Room 3$,'ULYHQ%LRORJ\DQG7R[LFRORJ\
Chairs: Masatoshi HAGIWARA (Department of Anatomy and Developmental Biology, Graduate School of
Medicine, Kyoto University)

Jun KANNO (National Institute of Health Sciences),QWURGXFWLRQ
14:00 - 14:02

6
14:02 - 14:32$,EDVHGRPLFVGDWDDQDO\VHVDQGWKHLUDSSOLFDWLRQVWRV\VWHPVWR[LFRORJ\DQGGUXJGLVFRYHU\
Takeshi HASE1, 2, 3, 4 (1The Systems Biology Institute, 26%;%LR6FLHQFHV,QF3Tokyo Medical and Dental
4

University, Institute of Education, Keio University, Faculty of Pharmacy)

6
7/2 PM

14:32 - 15:02

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Masatoshi HAGIWARA (Department of Anatomy and Developmental Biology, Graduate School of Medicine,
Kyoto University)

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July 2 (Sat) 14:00 - 14:50 Room 4

Chair: Keiichiro SATO (Pharmacokinetics and Safety Assessment Dept., Nippon Shinyaku Co., Ltd.)(/*OREDO$VVHVVPHQWRIWKH,PSDFWVRI3KDUPDFHXWLFDO3ROOXWLRQ$OLVWDLU%2;$// (University of York)

Symposium 42

July 2 (Sat) 14:50 - 16:30 Room 4

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Hiroshi YAMAMOTO (Health and Environmental Risk Division, National Institute for Environmental
Studies)6
14:50 - 15:00

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Hiroshi YAMAMOTO (Health and Environmental Risk Division, National Institute for Environmental
Studies)6
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RIKXPDQSKDUPDFHXWLFDOVTakashi YAMADA (Division of Risk Assessment, Center for Biological Safety Research, National Institute of
Health Sciences)

Symposium 43

July 2 (Sat) 14:00 - 16:30 Room 5

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Chairs: Makiko KUWAGATA (Division of Cellular & Molecular Toxicology, National Institute of Health Sciences)
Kentato TANEMURA (Laboratory of Animal Reproduction and Development Graduate School of
Agricultural Science Tohoku University),QWURGXFWLRQ
14:00 - 14:02

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14:08 - 14:43

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Noriyuki KOIBUCHI (Department of Integrative Physiology, Gunma University Graduate School of
Medicine)e61

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15:18 - 15:53

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15:53 - 16:28'HYHORSPHQWRILQYLWURGHYHORSPHQWDOQHXURWR[LFLW\DVVHVVPHQW
Yasunari KANDA (Division of Pharmacology, National Institute of Health Sciences)&RPSDUDWLYH7K\URLG$VVD\&XUUHQWVLWXDWLRQRIDVKRUWWHUPin vivo
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Tomoya YAMADA (Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.)(QYLURQPHQWDOIDFWRUVWKDWDႇHFWWK\URLGIXQFWLRQVDQGIXWXUHJHQHUDWLRQVKHDOWK(SLGHPLRORJLFDOSHUVSHFWLYHV
Shoji F. NAKAYAMA (Health and Environmental Risk Division, National Institute for Environmental
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16:28 - 16:30

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Symposium 44

July 2 (Sat) 14:00 - 16:30 Room 6&OLQLFDODGYHUVHHYHQWVVLGHHႇHFWVWKDWDUHGLႈFXOWWRGHWHFWLQJHQHUDO
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Tamio FUKUSHIMA (Shionogi Co & Ltd.),QWURGXFWLRQ
14:00 - 14:02
Izuru MIYAWAKI (Sumitomo Pharma Co., Ltd.)
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,PPXQRJHQLFLW\RIDQWLERG\WKHUDSHXWLFVMasayuki MISHIMA (Translational Research Division, Chugai Pharmaceutical)
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UHOHYDQFHWRSV\FKRWURSLFGUXJVYukihiro NODA1, 2 (1Division of Clinical Sciences and Neuropsychopharmacology, Faculty of Pharmacy, Meijo
2

University, Clinical OMICs and Translation Research Center, Meijo University)

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0HFKDQLVPVDQGSUHGLFWLRQRIVHYHUHFXWDQHRXVDGYHUVHGUXJUHDFWLRQVYoshiro SAITO (Division of Medicinal Safety Science, National Institute of Health Sciences)&RQFOXVLRQ
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14:00 - 14:13:
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Yukinori AMANO (JSOT Science and Publicity Committee)
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Kazuhiko MORI (Daiichi Sankyo RD Novare CO., LTD.)
Hideshi TSUSAKI (Shin Nippon Biomedical Laboratories)
Kouichi YOSHINARI (Laboratory of Molecular Toxicology, School of Pharmaceutical Sciences,
University of Shizuoka)

Makoto SHIBUTANI (Tokyo University of Agriculture and Technology, Institute of Agriculture,
Cooperative Division of Veterinary Science)

Moderator
Yukinori AMANO (JSOT Science and Publicity Committee)
Symposium 45

July 2 (Sat) 15:00 - 16:30 Room 7,&+(6%4 $8SGDWHDQG3URVSHFWVChairs: Takashi YOSHINAGA (Advanced Biosignal Safety Assessment, Eisai Co., Ltd.)
Katsuyoshi CHIBA (Medicinal Safety-Precision Medicine, Daiichi Sankyo Pharma Development, Daiichi
Sankyo, Inc.),QWURGXFWLRQ
15:00 - 15:05
Takashi YOSHINAGA (Advanced Biosignal Safety Assessment, Eisai Co., Ltd.)
15:05 - 15:20

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Takashi YOSHINAGA (Advanced Biosignal Safety Assessment, Eisai Co., Ltd.)

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Sankyo, Inc.)

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July 2 (Sat) 14:00 - 16:00 Room 8

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Chairs: Yuhji TAQUAHASHI (Division of Cellular and Molecular Toxicology, Center for Biological Safety &Research, National Institute of Health Sciences)

Hiroshi MINESHIMA (Department of Drug Safety Research, Otsuka Pharmaceutical Co., Ltd.),QWURGXFWLRQ
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Hiroshi MINESHIMA1, 2 (1Department of Drug Safety Research, Otsuka Pharmaceutical Co., Ltd., 2NonClinical Evaluation Expert Committee, Drug Evaluation Committee, Japan
Pharmaceutical Manufactures’ Association of Japan):
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Kiyoshi MATSUMOTO1, 2 (1Non-Clinical Evaluation Expert Committee, Drug Evaluation Committee,
2

The Japan Pharmaceutical Manufactures’ Association of Japan, Strategy
and Operations, Preclinical and Translational Sciences, Research, Takeda
Pharmaceutical Company Limited):
15:13 - 15:53:
15:53 - 16:00

3KDUPDFRNLQHWLFVDWWKHGHYHORSPHQWDOVWDJHRIFKLOGUHQDQGMXYHQLOHVMotoharu KAKIKI (Global Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd.))RU6:KDWLVVXHVDUHWREHFRQVLGHUHGIURPQRZRQ"
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Research, National Institute of Health Sciences)

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The University of Tokyo)%LRSKDUPDFHXWLFDOV
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Tetsushi HIRANO (Faculty of Pharmaceutical Sciences, University of Toyama)

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University of Science)e65

PosterUniversity)

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University, Department of Environmental Science and Disaster Management,
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University of Agriculture and Technology)(QYLURQPHQWDOSROOXWDQWV
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Tohoku University)

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Takehiro NAKAMURA (Faculty of Pharmacy, Kindai University)

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Veterinary Medicine, Department of Poultry Diseases, Faculty of Veterinary
Medicine, Aswan University)

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