Auxinole: Auxin Inhibitor & Reagent for Auxin Inducible Degron
Experiments
30-00150 mg

30-001-5 50 mg x 5
Shipping and Storage: Ship at ambient temperature or at 4 °C and store at ‒20 °C.
Product name:auxinole

Chemical name: 1H-Indole-3-acetic acid, alpha-[2-(2,4-methylphenyl)2-oxoethyl]CAS Registry Number:

86445-22-9

Chemical Formula:

C20H19NO3

Molecular Weight:

321.37

Molecular structure of Auxinole, a competitive inhibitor of the TIR1 auxin receptor

To make a 200mM stock solution, dissolve 50 mg of auxinole in 0.77 ml of DMSO. Storethe stock solution below ‒20 °C until use. See Ref 1 for details.

References: The use of auxinole to control human proteins by the AID technology isshown in Ref 1. The use of auxinole for plants and the synthesis method are describedin Ref. 2.
1. Yesbolatova A et al. Generation of conditional auxin-inducible degron (AID) cells andtight control of degron-fused proteins using the degradation inhibitor auxinole.
Methods. 2019 Apr 24. pii: S1046-2023(18)30331-1. PMID: 31026591
2. Hayashi K et al. Rational design of an auxin antagonist of the SCF(TIR1) auxin
receptor complex. ACS Chem Biol. 2012 Mar 16;7(3):590-8. PMID: 22234040

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MATERIAL SAFETY DATA SHEET
1. IDENTIFICATION
Product name:auxinole

Chemical name: 1H-Indole-3-acetic acid, alpha-[2-(2,4-methylphenyl)2-oxoethyl]Product code:30-001

Supplier:

BioAcademia Inc.

Address:

North Building, Research Institute for Microbial Diseases, OsakaUniversity, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan
Telephone: 81-6-6877-2335Fax: 81-6-6877-2336

E-mail: info@bioacademia.co.jp

2. HAZARDS IDENTIFICATIONClassification of the substance or mixture: Substance
PHYSICAL HAZARDS:

Not classified

HEALTH HAZARDS:

Not classified

ENVIRONMENTAL HAZARDS:

Not classified

Label elements
Pictograms or hazard symbols:

None

Signal word:

No signal word

Hazard statements:

None

Precautionary statements:

None

3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture:

Substance

CAS Registry Number:

86445-22-9

Chemical Formula:

C20H19NO3

Molecular Weight:

321.37

Notice Through Official Gazettes Reference Number
ENCS: Not Listed
4. FIRST-AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable forbreathing. Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin withwater/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. If eye irritation persists: Get medicaladvice/attention.
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Ingestion: Get medical advice/attention if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as
rubber gloves and air-tight goggles.
5. FIRE-FIGHTING MEASURES
Suitable extinguishing media: Dry chemical, foam, water spray, carbon dioxide.
Specific hazards arising from the chemical: Take care as it may decompose upon
combustion or in high temperatures to generate poisonous fume.
6. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing
7. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so thatworkers should not be exposed directly. Also install safety shower and eye bath
Control parameters: Not set up
Personal protective equipment
Respiratory protection:

Dustrespirator.

Follow

localandnationalregulations.
Hand protection:

Protective gloves.

Eye protection:

Safety glasses.

Skin and body protection:

Protective clothing.

8. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C):

SolidForm:

Crystal- Powder

Color:

hiteOdor:

No data available

pH:

No data available

Flammability or explosive limits:
Lower:No data available

Upper:No data available

Relative density:

No data available

Solubility(ies): [Water] No data available,[Other solvents] Soluble: methanol, acetone, DMSO, DMF
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9. STABILITY AND REACTIVITY
Chemical stability:

Stable under proper conditions.

Possibility of hazardous reactions:

No special reactivity has been reported.

Incompatible materials:

Oxidizing agents

Hazardous decomposition products:

Carbon monoxide, Carbon dioxide, Nitrogenoxides (NOx)
10. TOXICOLOGICAL INFORMATION
Acute Toxicity:

No data available

Skin corrosion/irritation:

No data available

Serious eye damage/irritation:

No data availableGerm cell mutagenicity:

No data available

Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity:

No data available

11. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish:

No data available

Crustacea:

No data available

Algae:No data available

Persistence / degradability:

No data available

Bioaccumulative potential(BCF): No data available
Mobility in soil
Log Pow:

No data available

Soil adsorption (Koc):

No data available

Henry's Law

No data available

constant(PaM3/mol):
12. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able
to dissolve or mix material with a combustible solvent and burn in a chemical
incinerator equipped with an afterburner and scrubber system. Observe all federal,state and local regulations when disposing of the substance.
13. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
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UN-No: Not listed
14. REGULATORY INFORMATIONNo chemicals in this material are subject to the reporting requirements of SARA Title
III, Section 302, or have known CAS numbers that exceed the threshold reportinglevels established by SARA Title III, Section 313.
10. OTHER INFORMATIONThis MSDS is correct to the best of our knowledge at the date of publication but does
not purport to be all inclusive and shall be used only as a guide. It must only behandled by suitably qualified experienced scientists in appropriately equipped andauthorized facilities. The burden of safe use of this material rests entirely with theuser. Bioacademia Inc. shall not be held liable for any injury or damage resulting fromhandling or from contact with the above product.
This product is to be used for research purpose only, not in human.

BioAcademia,Inc.

Tel. 81-6-6877-2335

Fax. 81-6-6877-2336

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