IMPACTFACTORInternational Journal ofMolecular Sciences

4.183

an Open Access Journal by MDPI

Diagnostic Challenge and Therapeutic Approaches in Human Sepsis
Based on the Appearance of Endotoxemia and Beta-D-Glucanemia
Guest Editors:

Message from the Guest Editors

Dr. Hiroshi Tamura
LPS (Laboratory ProgramSupport) Consulting Office, Tokyo
160-0023, Japan;
Department of Host Defense andBiochemical Research, Juntendo
University Graduate School ofMedicine, Tokyo 113-8431, Japan;
Tokyo University of Pharmacy
and Life Science, Tokyo 192-0392,
Japan

Endotoxins, also called lipopolysaccharides (LPS), are themajor constituent of the outer membrane of Gram-negative
bacteria. Fungal (1→3)-beta-D-glucan, a major componentof the cell wall as well as endotoxin, have attracted aconsiderable amount of interest in applications as potential
prognostic, diagnostic, and therapeutic markers in blood orbody fluids.

htamura@lpsct.com
Dr. Yoshiyuki Adachi
Laboratory for
Immunopharmacology ofMicrobial Products, School ofPharmacy, Tokyo University ofPharmacy and Life Sciences,
Tokyo 192-0392, Japanadachiyo@toyaku.ac.jp

Deadline formanuscript submissions:
31 December 2020

mdpi.com/si/48852

In this Special Issue, we will focus on cellular and molecularmechanisms of endotoxin/beta-D-glucan activities; recent
advances, limitations, and further challenges to the early
detection of endotoxemia/beta-D-glucanemia, primarily
with the Limulus amebocyte lysate assay (conventional/recombinant); and promising therapeutic approaches basedon cytokine/chemokine blockades, anti-endotoxin agents,
host defense (antimicrobial) peptides, antifungal agents,
highly eﬀective anticoagulants, or direct hemoperfusion, withthe aim to pave the way to successful innovative treatments
and management of sepsis or septic shock.
Dr. Hiroshi Tamura
Dr. Yoshiyuki Adachi
Guest Editors

SpecialIssue

IMPACTFACTORInternational Journal ofMolecular Sciences

4.183

an Open Access Journal by MDPI

Editors-in-Chief

Message from the Editorial Board

Prof. Dr. Charles Brennan

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