Acoustic Sample Management
TRANSFORMING SAMPLE MANAGEMENT WITH ACOUSTIC LIQUID HANDLING

Access™
for Acoustic Sample Management
BROCHURE
Version 1.1 | APRIL 2018

LABCYTE INC.
170 Rose Orchard Way
San Jose, CA 95134
Toll-free: +1 877 742−6548 | Fax: +1 408 747−2010© 2018 LABCYTE INC. All rights reserved.

SLAS2018 | ACCESS™ DUAL ROBOT SYSTEM

ACOUSTIC SAMPLE MANAGEMENT SOLUTION

Acoustic Sample Management
Acoustic Sample Management optimizes sample library design and distribution for a smarter approach to high-throughput screening. This fully
tip-less, non-contact solution enabled by acoustic liquid handling sets new standards for sample integrity, sample management efficiency, and dataquality.

Access™ Dual Robot System
The Access Dual Robot System (DRS) is a modular and configurable
automation platform optimized for sample management workflows andintegration with the new Echo® 655T Liquid Handler.
• Configured to achieve optimal throughput for sample management
workflows• Compact and ergonomic design with docking modules, turntables,
retractable shelves, and drawers• Optional features can include environmental management to protect
samples from hydration or evaporation

Echo® 655T Liquid Handler
The latest addition to the family of Echo Liquid Handlers, the Echo 655T Liquid Handler supports sample
transfer directly from storage tubes to enable fully non-contact liquid handling workflows from sample
storage all the way to assay-ready plates.
• Non-contact transfer from Echo® Qualified Microplates and Tubes• Transfer of fluids for ‘Omics and Screening applications• Accurate and precise transfer of samples in volumes as low as 2.5 nanoliters• Avoids risk of compound loss, carryover, and contamination• Minimizes sample hydration and evaporation with purge-able transfer zone

Acoustic Liquid Handling from Tubes – A Groundbreaking Innovation
Acoustic Sample Management adds flexibility to workflows and enables researchers to benefit from the advantages of acoustic liquid handling earlier
in the sample management process.

MAXIMIZEINCREASE

IMPROVEACCELERATELab Budget

Data Quality

Sample Integrity

Productivity• Miniaturize assays• Minimize sample loss

• Minimize sample exposure• Validate hits faster• Conserve sample and reagent• No pipetting variances• Eliminate tip costs• Eliminate carryover• Eliminate unnecessary
freeze-thaw cycles• Transfer samples acousticallywithout source plates• Reduce workflow steps• No cross-contamination• Limit hydration and evaporation• Create dose response curves
starting from source tubes

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FULLY ACOUSTIC WORKFLOWS FOR SAMPLE MANAGEMENT

Fully Acoustic Workflows for Sample Management
The introduction of acoustic tubes enables fully acoustic sample management workflows and offers all the benefits of tip-less liquid transfer, startingat sample preparation. Acoustic tubes coupled with the Echo 655T Liquid Handler and Access Dual Robot System offer superior results for sample
management applications.
• Primary Screening• Hit Validation• Assay-ready Plate Production• Secondary Screening• Dose Response, IC50, EC50

• Targeted Screening

Primary Screening
Primary screening workflows benefit from a completely acoustic liquid handling solution, eliminating the risk of sample contamination or loss. Sample
transfers can be made directly from source acoustic tubes to source plates or assay-ready plates.

Fully Acoustic Liquid Handling Solution
Acoustic Tube Racks

Source Plates

Assay-ready Plates

Fully Acoustic Liquid Handling Solution
Acoustic Tube RacksSource Plates
Fully Acoustic Liquid
Handling Solution

Assay-ready Plates

Acoustic Tube Racks

Source Plates

Assay-ready Plates

Acoustic Tube Racks
Secondary
Screening

Assay-ready Plates

Whether you are verifying targets by re-screening
hitsHits
or creatingdose response curves, acoustic sample management workflows will validate hits 8xValidate
8X Faster
faster. The ability to cherry-pick
only
identified
hits
into aoftube
rack
prevents
unnecessary
freeze–thaw cycles and risk of hydration or evaporation due
Process625
tube racks
instead5,209384-wellsourceplates,when screening 2,000,000 compounds at a 3% hit rate.
toexposure
to Racks
the environment.
AcousticTube

Assay-ready Plates

Acoustic Tube Racks

Assay-ready Plates

Validate Hits 8X Faster
Process 625 tube racks instead of 5,209 384-well source plates,when screening
2,000,000compounds
at a 3% hit rate.
ValidateHits
8X Faster

Acoustic Tube Racks

Process 625 tube racks instead of 5,209 384-well source plates,when screening 2,000,000 compounds at a 3% hit rate.

Assay-ready Plates

Increase Data Quality of Dose Response Assays
Acoustic Tube Racks

Create curves and intermediate dilutions directly from tubes,
avoiding sample carryover and cross-contamination.

Acoustic Tube Racks

Assay-ready Plates
Assay-ready Plates

Increase Data Quality of Dose Response Assays
Create curves and intermediate dilutions directly from tubes,

avoidingsample
carryovercross-contamination.
Increase
DataQualityof andDose
Response Assays
Create curves and intermediate dilutions directly from tubes,
avoiding sample carryover and cross-contamination.
Intermediate Dilution PlatesIntermediate Dilution PlatesIntermediate Dilution Plates

3

SLAS2018 | ACCESS™ DUAL ROBOT SYSTEM

ACOUSTIC SAMPLE MANAGEMENT SOLUTION

Access™ Dual Robot System for Acoustic Sample Management
The Access DRS is a compact, modular, high-capacity, and high-throughput platform, designed and optimized for the use of Echo Liquid Handlers
in sample management workflows. It is the only automation platform on the market compatible with the Echo 655T Liquid Handler, enabling theproduction of assay-ready plates from acoustic sample tubes. The system combines industry-leading devices and software with ergonomic andenvironment management options to provide a complete, easy-to-use, store-to-assay sample management solution.

Maximum Throughput and Uptime
Two robotic arms efficiently feed devices to minimize robotic movement and streamline workflows. With redundancy across critical devices andenough capacity to store up to 672 tube racks and 1,120 destination plates, the system can continuously run unattended over nights and weekends.

Industry-leading Devices
Integrated components include high-capacity storage devices, high-speed and high-imbalance tolerant centrifuges, nanoliter-scale bulk dispensers,
acoustic tube cap removal devices, thermal sealers, seal peelers, microplate labelers, and barcode readers for sample tracking.

Compact and Ergonomic
Integrate more than 15 devices in a compact space without sacrificing user-friendly access to devices or access to the inside of the system.

4ACCESS™ DUAL ROBOT SYSTEM

ModularConfigure and reconfigure system modules to meet application needs. Dock and undock up to 6 standardized modules for integrating Echo systems,
plate handling devices, and plate stores.

Access to Devices
Easily access devices for standalone operation or maintenance by configuring system modules with retractable shelves, turntables, and automateddocking systems. The automated push button docking system allows operators to temporarily undock modules without stopping runs that are inprogress.

Preserve Sample Quality
An integrated environment distribution system avoids DMSO hydration,
maintains sample integrity, and ensures downstream data quality. The systemevenly distributes and recirculates conditioned air from laboratory HVAC
systems to each module of the platform, providing a dry, ambient internal
environment.

5SLAS2018 | ACCESS™ DUAL ROBOT SYSTEM

ACOUSTIC SAMPLE MANAGEMENT SOLUTION

Echo® 655T Liquid Handler
Due to their outstanding throughput, high transfer accuracy, nanoliter volume
precision, and any-well to any-well transfer capabilities, Echo Liquid Handlers havelong been integral to state-of-the-art sample management and high-throughput
screening solutions. Offering these same benefits, the Echo 655T Liquid Handler
now supports sample transfer directly from storage tubes in addition to 384well and 1536-well microplates, enabling a fully non-contact dispensing workflow
from sample storage all the way to assay-ready plates. The Echo 655T LiquidHandler seamlessly integrates with the highly configurable Access DRS, enablinga fully automated workflow. Whether your workflow requires plate reformatting,replication, hit picking, or adding samples and reagents for screening assays, theEcho 655T Liquid Handler and Access DRS will meet your needs.

FluidX™ AcoustiX™ Sample Tube by Brooks Life Sciences
The FluidiX AcoustiX Sample Tube (FAST) transforms sample management workflows by enabling acoustic dispensing directly from tubes. The
meticulous tube design features a revolutionary cap to increase automated capping cycles from 15 to over 500 cycles, a DMSO-resistant gasket toreduce hydration and evaporation, and replicate 2D barcodes that provide a clear path for acoustic energy to pass through to the sample.

• Preserve sample integrity fromstorage to screen

FluidX™ AcoustiX™ Sample Tube

• Miniaturize upstream liquid handlingsteps to conserve sample

Echo models

655T

Working volume

15 – 70 μL*• Rapidly pick subsets of samples fortargeted screening

Dead volume (Echo)< 15 μL

SampleStore™ II by Brooks Life Sciences
The SampleStore II is designed for reliability and storage density, with a modular
architecture to maximize adaptability. With the addition of the FluidiX AcoustiX
Sample Tube, dual shuttle robots, ultrahigh-density trays, and a quad tray lane, theSampleStore II has leveraged common architectures to facilitate higher density
storage and maximum throughput. Existing systems that can hold 300,000 1.4mL
tubes can now hold 1,180,000 FAST tubes in ultra high-density trays, in the same
system footprint.

6

an Echo® Qualified Consumable* Working volume is dependent on acoustic liquidhandling technology and fluid type.

ACCESS™ DUAL ROBOT SYSTEM

Tempo™ 2.0 Automation Control Software
With Tempo 2.0 software, Access DRS operators can easily coordinate plate handling tasks, manage consumable inventories, and report informationin real-time to LIMS or databases. Like previous versions, Tempo 2.0 software remains the only automation software that readily imports protocols
from Echo® Software Applications, simplifying protocol setup and schedule optimization.
Tempo 2.0 software includes new features to promote usability, throughput, and uptime.
• Multi-robot coordination• Advanced error recovery• Module and device presence detection• Simultaneous run processing and prioritization• Run throughput optimization• More methods for plate labeling• Improved integration with LIMS

• Integration with external laboratory or building management systems• Device and consumable utilization tracking• Inventory search capabilities

1Mosaic TFM by Titian Software
The Mosaic Tempo Fulfillment Module(TFM) from Titian Software combines
the scheduling power of Tempo
2.0 software with the inventory
management expertise of Mosaic
sample management software. This new4

2

module for Mosaic software captures
the exact transfer and survey volumes aswell as sample concentrations reported
by Echo Liquid Handlers. Combinedwith sample lifecycle information,
Mosaic software can better track sample
distribution, freeze-thaw cycles, andtube decap/cap operations to monitor
sample integrity and utilization.

1 Create order using Mosaic software
2 Retrieve samples from storage
3 Process order on Access DRS
4 Report sample and process information

37

LABCYTE INC.
170 Rose Orchard Way
San Jose, CA 95134
USA
Toll-free: +1 877 742−6548 | Fax: +1 408 747−2010

SALES
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Other| +1 408 747−2000| +353 1 6791464| +81 03 5530 8964
| +61 39018 5780
| +1 408 747−2000| info-us@labcyte.com| info-europe@labcyte.com| info-japan@labcyte.com| info-us@labcyte.com| info-us@labcyte.com

All product names and brands are properties of their respective owners.
© 2018 LABCYTE INC. All rights reserved. Labcyte®, Echo®, MicroClime®, the Labcyte logo, Access™, Tempo™, andDynamic Fluid Analysis™ are registered trademarks or trademarks of Labcyte Inc., in the U.S. and/or other countries.
FOR RESEARCH USE ONLY. Not for use in diagnostic procedures.

BRH-ADRS-1.1
APR 2018