Small Molecule Preformulation

Kick your preformulation screening into high gear
Freeslate systems give you automated, high-throughput, end-to-end solutions tocharacterize every last physicochemical property of your drug candidates. They’recompletely configurable and built to take on the hard stuff. Churn through morestructures and conditions earlier, find out what’s worth formulating sooner and get tothe best druggable form of your API pronto.

• Solubility screening• Polymorph screening• Powder dispensing• Reaction screening

Supercharge your workflow
Freeslate lets you run hundreds of experiments in parallel with way less material, sodeep exploration of your preformulation space is totally doable. Pick your variables,
map out your workflow and get it all done on one system. See the big picture moreclearly, discover clues and spot more advantageous variables and conditions.

19283

12
345

45Vial/plate gripper
Balance with visual Inspection
Powder dispense hopper rack
Passive rack
Tip rack

678
96

7

3-Position heating/stirring
3-Position heating/stirring
Heated filter block
Heated 4-tip liquid dispenser

Get your crystals on
Give the number of crystalline forms you can characterize on your API a big-time boost
with freeslate’s 8 x 12 array crystallization assembly. Heat or cool samples right on thedeck. The universal substrate lets you analyze samples by birefringence, XRD andRaman spectroscopy without wrecking a single crystal.

Crystallization assembly with
universal substrate plate

Integrated structural characterization by XRD

Stay soluble
Freeslate’s temperature-controlled pipetting and filtering help get your API’s intosolution. Keep them from precipitating on you when you add or remove reagentsusing a heated dispense element with septum piercing tips for sealed vials. A heatedfilter block with 96 isolated sample wells erases any chance of well-to-well crosscontamination, so you can get the conditions just right.

Heated dispense elementwith septum-piercing tips

Crystallizer block for polymorph screeningGo sticky or solid
Spot-on pipetting, dispensing and weighing of viscous and solid materials means
you’re accurately evaluating your formulated drugs. Freeslate’s positive displacement
pipetting handles the stickiest stuff out there — even at low volumes. Solid dispensers
use an adaptive learning algorithm to accurately dispense and weigh powders. They
also remember optimal settings so you get fast, reproducible dosing every time.

Viscous liquid
dispenser handles
up to 1000 cP

Classic Hopper
uses active stirring
for uniform flow rate

SV dispensers
use vibration for
precise delivery

Break through bottlenecks
LEA doesn’t move the bottleneck, it totally unclogs it. You get intuitive experimental designthat makes sense on the front end and full integration with analytical tools on the backend. LEA also links your conditions, steps and analytical data together so your final reportdoesn’t just have numbers, it’s got all the information you need to make real decisions.

Library Studio
Design complex, high-throughput
experiments in an array-basedformatPolyView
Review and report all info
from experimental design,
execution and analytics

Automation Studio
Execute designed experiments
and integrated analytics

Unchained Labs
6940 Koll Center Pkwy, Suite 200
Pleasanton, CA 94566
Phone: 1.925.587.9800
Toll-free: 1.800.815.6384
Email: info@unchainedlabs.com© 2016 Unchained Labs. All rights reserved. The Unchained Labs logo and freeslate are trademarks
and/or registered trademarks of Unchained Labs.