August 31, 2016

Mandom Discovers the Scalp-Softening Effectof Keratinocyte Growth-Factor- Mimicking
PeptidesMandom Corporation (Headquarters: Osaka; CEO: Motonobu Nishimura; hereinafter, “Mandom”) conducted astudy of the scalp in Japanese men, in collaboration with Ayako Ito, Director of the Medical Corporation Xanadu Ayako
Ito Clinic, with the aim of improving the functionality of cosmetic products (quasi-pharmaceuticals).
Previous studies showed that the scalp of men with thinning hair is harder and contains a higher quantity of sebuml. ※The present study was conducted with the aim of improving poor scalp condition, and it showed that the scalp wassoftened and its condition improved by applying keratinocyte growth-factor-like peptides (oligopeptide-41; hereinafter,KGF- mimicking peptides).
The results of this study were announced at the 34th Annual Meeting of the Japanese Society of Aesthetic
Dermatology held from 8/6 to 8/7/2016.
*Reference:
12/14/2015 News Release“Mandom reveals the actual state of the easily damaged male scalp and the improvement effect ofscalp lotion.”
1. Focus on improving hard scalp in order to prevent hair loss in the future
In its previous research on the male scalp, Mandom determined that the scalps of men with thinning hair in their 30s
to 40s were harder and contained a higher content of skin oil than the scalps of men of the same age without thinning
hair.
Believing that the scalp must be softened and its condition improved to preventhair loss in the future, Mandominvestigated the effect of KGF-mimicking peptides, which have a structure similar to KGF and are said to promote thekeratinocytes and activate dermal papilla cells, on the improvement in the scalp condition.
2. Effect of KGF- mimicking peptides (oligopeptide-41) on the scalp
Forty-two healthy Japanese men were divided into 2 groups. In one group, a scalp model lotion containing KGFmimicking peptides was applied, and in the other group, a scalp model lotion that did not contain these peptides wasapplied. In both groups, the lotions were applied once daily for a period of 4 weeks, and the change in scalp hardness
before and after application was measured. When the scalp model lotion was applied, it was applied to the surface of theskin gently in order to prevent effects due to massaging. The results showed that the scalps of men who applied scalp
model lotion containing KGF- mimicking peptides became softer in both the parietal and occipital regions of the head.

(Figure 1, Figure 2)
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-1-The scalp was understood to become softer from using scalp model lotion, but the present study showed that thescalp was softened more and its condition was even more improved as a result of the additive effect of the KGFmimicking peptides, in addition to the moistening effect of the scalp lotion. Mandom will continue to study the male
scalp in the future and apply the findings in developing scalp-care products.
<References>
Change in scalp hardness due to repeated application of model scalp lotion
Figure 2. Occipital region

Contains KGF-likepeptides

Does not contain KGFlike peptides

Contains KGF-like peptides Does not contain KGF-like peptides

Change in hardness (°)

Change in hardness (°)

Figure 1. Parietal region-2-