CardioExcyte 96
Contractility. Electrophysiology. Viability.

CardioExcyte 96

Human physiology and diseasemodels in a dish
The CardioExcyte 96 offers a unique experimental

With embedded control electronics andconstellation, uniting electrical field potential (EFP)

sophisticated impedance sensor technology,

and contractility readouts from the same cells,

the CardioExcyte 96 is a turn-key system forsuch as human iPSC derived cardiomyocytes. Thisefficient cardiac safety screening and long-term

gives valuable insight in both electrophysiologicalmonitoring of cell viability and toxicity in 2Dand mechanical cellular phenotypes.

and 3D.

Although small in footprint, this powerful
instrument performs fully automated recordings
from 96 wells in parallel.

CardioExcyte 96

Key features at a glance1

96 recording wells in parallel

5

High resolution, real-time accessto beating parameters

2

Contractility and EFP recordings
from the same cells

6

Acute and chronic assessmentof cell activity and toxicity

3

Physiological and hypoxia environment

7Electrical and optical pacing options

4

Non-invasive & label-freemeasurements

8

Cost efficient consumables

CardioExcyte 96Sophisticated solutions for
cardiac researchStandardized protocols

Automated arrhythmia detection

Standardized recording and analysis protocols for

Automated detection of arrhythmic events allows

highly resolved impedance and EFP recordingsa fast and accurate analysis process over multiple

performed on CardioExcyte 96 are derived

wells simultaneously.

from the efforts of the Comprehensive In vitro
Proarrythmia Assay (CiPA) myocyte working• Real-time geometric beat analysis

group.

• Intelligent peak detection with primary andsecondary (arrhythmia) beat distinction• Compound Arrhythmia Factor analysis

Electrophysiology

ImpedanceCardioExcyte 96

Versatile data analysis andfast data handling
CardioExcyte 96 control is an easy-to-use yet

DataControl 96 allows fast and accurate analysis

very powerful software enabling recording andand standardized processes by automatedonline analysis of a broad range of beating

preloading of recorded files and custom definedparameters.

analysis templates.

• Online monitoring of raw data traces, mean
beat and online analysis all in one single screen• Extremely powerful, yet easy to use analysis
software• Intuitive and easy to navigate• Instant recalculation of data upon parameterchanges with broad range of QC options• Versatile cardiac readouts: Beat rate/regularity,amplitude, FPD-max, FPD-zero, rise and fall time,
pulse width etc.
• Base impedance readout• Sensor temperature readout

CardioExcyte Control 96
The unique Mean Beat Function automatically visualizes
the average of EFP or impedance traces from one well,enveloped by the standard deviation, indicating theconsistency of the beat pattern within the recording wells,
i.e. if the cellular network is synchronously beating or not.

• Control group normalization or pooling of data
• Compound effects visible in seconds• Highly customizable exporting to databases

CardioExcyte 96

Your research, our passion

Cardiac activity profiling

Assay development and validation

Electrical and contractile fingerprint ofFull flexibility to design assays for a wide variety of

iPSC-derived cardiomyocytes.

cell lines.

Cardiac safety and toxicity

CiPA validation study

Designed to detect toxic compound effects

The CardioExcyte 96 is delivered with all the CiPAand abnormal beating patters.

validated protocols.

Academic researchDisease modeling

Easy solutions tailored to ensure your next

Investigate various diseases in a dish using patientscientific breakthroughs.

derived cells.

Pharma and CROs

Beyond cardiomyocytes

Suitable for standardized screens, with fast,

Electrical impedance spectroscopy allows for

precise and reproducible results.

monitoring of cell viability and more.

CardioExcyte 96

The CardioExcyte 96 includes• Recording system with environmental control and a gas mixer (hypoxia feature optional)• Impedance and electrical field potential (MEA-like) recordings• Recording and analysis software package• Automated multichannel pipetting—Integra Viaflo Assist (optional)• SOL optical stimulation (optional)• Various CardioExcyte recording plates• 1 year warranty with further optional comprehensive service plans available• Unmatched application support

Specifications
Supported recording modes

Impedance-, electric field potential (MEA-like) recordings

Impedance / EFP resolution

Imp: 1 ms / EFP: 0.1 ms

Impedance aquisition frequency

10 kHzParallel recording channels

96

Temperature sensing

Multi-sensor temperature control

Validated human induced pluripotent stem cells

Yes

Validated embryonic stems cells

YesStand-alone system

Integrated Incubation System

Automated liquid handling

Integra Viaflow Assist

Cardiac cell pacing

Electrical and optical (optional)

Plates available

Standard plates, stimulation plates, transparent platesaccelerate your researchnanion Europe
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phone: 1-888-9-NANION
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www.nanion.jp

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