Press Release
Tokyo, June 1, 2020

Torii and ASKA Enter into Co-Promotion Agreement Concerning Additional
Indication of Iron Deficiency Anemia for Riona®
Torii Pharmaceutical Co., Ltd. (Head Office: Chuo-ku, Tokyo, President: Goichi Matsuda,
hereinafter "Torii") currently distributes and markets Riona® Tablets 250mg (genericname in Japan: ferric citrate hydrate, development code: JTT-751, hereinafter "Riona®")for the improvement of hyperphosphatemia in patients with chronic kidney disease, forwhich Japan Tobacco Inc. (hereinafter "JT") has filed an additional indication for irondeficiency anemia (IDA) (hereinafter the "New Indication"). Torii and ASKA
Pharmaceutical Co., Ltd. (Head Office: Minato-ku, Tokyo, President: Takashi Yamaguchi,hereinafter "ASKA") have entered into a co-promotion agreement (hereinafter the"Agreement") that covers this New Indication for Riona®.
Under the Agreement, once the New Indication has been approved by PMDA, Torii andASKA will jointly engage in the marketing of Riona®’s the New Indication. Torii will mainly
focus on medical institutions with chronic kidney disease-related departments, such as
nephrology and dialysis, while ASKA will mainly focus on medical institutions withobstetrics and gynecology.
As a specialty pharma company that focuses on the obstetrics and gynecology area,
ASKA is striving to expand its portfolio of relevant products. Through the co-promotionof Riona®, it will endeavour to further strengthen its presence in the market.
By co-promoting Riona® with ASKA, which has extensive experience in the obstetrics
and gynecology area, Torii believes that it will be able to provide wider information aboutRiona® more effectively for relevant medical professionals.
Through these co-promotion activities, Torii and ASKA intend to build a close
collaborative relationship, with the aim of the early establishment of Riona ® as a new
option to help patients with iron deficiency anemia.

ABOUT Riona® Tablets 250mg“Riona® Tablets 250mg” is approved and marketed for the treatment ofhyperphosphatemia in adult patients with chronic kidney disease (CKD) both on dialysis
and not on dialysis in Japan. JT and Torii hold the exclusive rights in Japan for its
development and commercialization of Riona ® under the agreement dated September
26, 2007 with Keryx Biopharmaceuticals, Inc., a wholly owned subsidiary of Akebia
Therapeutics, Inc. JT received approval for Riona® on January 17, 2014 and Torii has
been promoting and distributing products Riona ® since May 12, 2014.
In the United States, ferric citrate is approved and marketed by Akebia Therapeutics,
Inc. under the trade name Auryxia® for the control of serum phosphorus levels in adultpatients with CKD on dialysis and for the treatment of IDA in adult patients with CKD noton dialysis.

ABOUT IDA
IDA is the most frequent anemia, which is caused by decreasing hemoglobin production
due to iron deficiency. IDA involves symptoms of anemia with palpitations and shortnessof breath, as well as pica, fatigability, etc., which leads to the decrease in the patient's
quality of life. The treatment for IDA is the iron supplementation and the correction of theunderlying cause.

Company overview【Torii Pharmaceutical Co., Ltd.】
1. Establishment：November, 1921
2. Location：Torii Nihonbashi Bldg., 4-1, Nihonbashi-Honcho 3-chome,
Chuo-ku, Tokyo, 103-8439
3. Capital：JPY 5,190 million
4. Number of Employees：660 (As of December 31,2019)
5. Net sales：JPY 42,998 million results（Year ended December 31, 2019）【ASKA Pharmaceutical Co., Ltd.】
1. Founded：June, 1920
2. Location：5-1, Shibaura 2-Chome, Minato-ku, Tokyo, 108-8532
3. Capital：JPY 1,197 million
4. Number of Employees：807 (As of March 31,2020)
5. Net sales：JPY 52,542 million results（Year ended March 31, 2020）

Contact for Torii Pharmaceutical Co., Ltd.
Corporate Planning Department (Public Relations)
Torii Pharmaceutical Co., Ltd
E-mail: webmaster@torii.co.jp
Tokyo: +81-3-3231-6814
Contact for ASKA Pharmaceutical Co., Ltd.
Corporate Planning Department
ASKA Pharmaceutical Co., Ltd.
E-mail: kouhou@aska-pharma.co.jp
Tokyo: +81-3-5484-8366