Table 1. Infectious agents and toxins corresponding target diseases of the Infectious
Diseases Control Law revised on June 1, 2007
Diseasecategory

BSL

South American hemorrhagic fever

I4Lassa fever

I4

Ebola hemorrhagic fever

I4

Smallpox
Crimean-Congo hemorrhagic fever
Marburg disease

III

4
4
4Infectious agent or toxin*Arenavirus
Arenavirus
Group 1
Ebolavirus
Orthopoxvirus
Nairovirus
Marburgvirus

Group 2

Yersinia
Clostridium
Coronavirus
Bacillus
Francisella
Botulinum toxin

Yersinia pestis
Clostridium botulinum
Severe acute respiratory syndrome coronavirusBacillus anthracis
Francisella tularensis (subsp. holarctica, tularensis)

PlagueBotulism
Severe acute respiratory syndrome
Anthrax
Tularemia
Botulism

IIVIIIVIVIV

3
23
3
3
2

Alphavirus
Alphavirus
Alphavirus
Orthopoxvirus
Coxiella
Coccidioides
Simplexvirus
Burkholderia
Burkholderia

Eastern equine encephalitis virus
Western equine encephalitis virus
Venezuelan equine encephalitis virus
Monkeypox virus
Coxiella burnetii
Coccidioides immitis
Cercopithecine herpesvirus 1（B virus）
Burkholderia pseudomallei
Burkholderia mallei
Andes virus
Bayou virus
Black Creek Canal virus
Laguna Negra virus
New York virus
Sin Nombre virus
Dobrava-Belgrade virus
Hantaan virus
Puumala virus
Seoul virus
Rift Valley fever virus
Omsk hemorrhagic fever virus
Kyasanur Forest disease virus
Tick-borne encephalitis virus
Brucella abortus
Brucella canis
Brucella melitensis
Brucella suis
Nipah virus
Hendra virus
Mycobacterium tuberculosis (multi-drug resistant
M. tuberculosis; resistant at least to isoniazid andrifampicin)
Rickettsia japonica
Rickettsia prowazekii
Rickettsia rickettsii
Rabies virus
Rabies virus fixed strain

Eastern equine encephalitis
Western equine encephalitis
Venezuelan equine encephalitis
Monkeypox
Q fever
Coccidioidomycosis
Herpes B virus infection
Melioidosis
GlandersIVIVIVIVIVIVIVIVIV

3
33
2333
3
3Hantavirus pulmonary syndrome

IV

3Hemorrhagic fever with renal syndrome

IV

3

Rift Valley fever
Omsk hemorrhagic fever
Kyasanur Forest disease
Tick-borne encephalitis

IVIVIVIV33
33

BrucellosisIV

3

Nipah virus infection
Hendra virus infection

IVIV

3
3

Tuberculosis

II3Japanese spotted fever
Epidemic typhus
Rocky Mountain spotted fever

IVIVIVIVIV

33332VIV
IVIII
IIIV
V
IIIIII

232222233III

2III
IVIV
IVIV

23322II

3III

2Hantavirus

Hantavirus
Group 3
Phlebovirus
Flavivirus
Flavivirus
Flavivirus
Brucella
Henipavirus
Henipavirus
Mycobacterium
Rickettsia
Rickettsia
Rickettsia
Lyssavirus
Influenzavirus A
Influenzavirus A
Escherichia
Enterovirus
Chlamydophila
Cryptosporidium
Salmonella
Salmonella
Group 4

Guanarito virus
Junin virus
Machupo virus
Sabia virus
Lassa virus
Cote d'Ivoire ebolavirusReston ebolavirus
Sudan ebolavirus
Zaire ebolavirus
Variola virus
Crimean-Congo hemorrhagic fever virus
Lake Victoria marburgvirus

Target disease

ShigellaVibrioFlavivirus
Flavivirus
Flavivirus
Flavivirus
Mycobacterium
Shiga toxin

RabiesInfluenza A virus (H2N2)
Influenza
Influenza A virus (H5N1, H7N7)
Avian influenza virus infection
Influenza A virus (H5N1, H7N7) low pathogenic strain
Escherichia coli (enterohemorrhagic E. coli）
EHEC infection
Poliovirus
Acute poliomyelitis
Chlamydophila psittaci
Psittacosis
Cryptosporidium parvum (genotype I, II）
Cryptosporidiosis
Salmonella enterica subsp. enterica serovar Typhi
Typhoid fever
Salmonella enterica subsp. enterica serovar Paratyphi A Paratyphoid fever
Shigella boydii
Shigella dysenteriae
Shigellosis
Shigella flexneri
Shigella sonnei
Vibrio cholerae (serotype O1, O139）
CholeraYellow fever virus
Yellow fever
West Nile virusWest Nile fever
Dengue virus
Dengue fever
Japanese encephalitis virus
Japanese encephalitis
Mycobacterium tuberculosis (excluding multi-drug
Tuberculosis
resistant M. tuberculosis）
Shigellosis, EHEC infection* Refer to "Technical Terms of Microbiology: English-Japanese/Japanese-English" (Nanzando) , 2007

BSL: biosafety level