REACH໬Ꮫ≀㉁Ᏻ඲ᛶホ౯
(CSA)

Dinant KroeseTNOᛂ⏝⛉Ꮫ◊✲ᶵᵓࢡ࢜ࣜࢸ࢕࣭࢜ࣈ࣭ ࣛ࢖ࣇ㒊㛛ෆᐜ
1.
2.

Ⓩ㘓せ௳REACH࡟ᇶ࡙ࡃࢥ࢔࣭ࢶ࣮ࣝ

3.

໬Ꮫ≀㉁Ᏻ඲ᛶホ౯ࡢᡭ㡰࣭ே೺ᗣ࣭⎔ቃ⾨⏕࢞࢖ࢲࣥࢫཬࡧࢶ࣮ࣝ

4.

1. Ⓩ㘓せ௳㸸
1. ᢏ⾡୍ᘧᩥ᭩ (TD)2. ໬Ꮫ≀㉁Ᏻ඲ᛶሗ࿌᭩(CSR)! 1 ࢺࣥ/ᖺ
! 10 ࢺࣥ/ᖺ

TDࡢ᭩ᘧ
------------------------------------------------------------------------------------------------------------------------------! 〇㐀⪅/㍺ධ⪅ࡢ≉ᐃ≀㉁ࡢ㆑ู
〇㐀ཬࡧ⏝㏵࡟㛵ࡍࡿ᝟ሗ≀㉁ࡢศ㢮ཬࡧ⾲♧Ᏻ඲࡞⏝㏵࡟㛵ࡍࡿ࢞࢖ࢲࣥࢫ㝃ᒓ᭩ VII ࠿ࡽ㝃ᒓ᭩ XI ࡢ㐺⏝࡟⏤᮶ࡍࡿ≀㉁ࡢᅛ᭷ࡢ≉ᛶ࡟㛵ࡍࡿ㸦ࣟࣂࢫࢺ㸧ヨ㦂せ⣙᭩! ୖグࡢ஦㡯ཬࡧ/ཪࡣ㸦ヱᙜࡍࡿሙྜࡣ㸧CSRࡀホ౯⪅࡟ࡼࡗ࡚ࣞࣅ࣮ࣗࡉࢀࡓ࠿࡟ࡘ࠸࡚ࡢ⾲♧! ヱᙜࡍࡿሙྜࡣ㏣ຍヨ㦂࡟㛵ࡍࡿᥦ᱌! 1ࢺࣥ࠿ࡽ10ࢺࣥࡢ≀㉁࡟㛵ࡋ࡚ࡣࠊ≀㉁ࡢࡤࡃ㟢㛵㐃᝟ሗ㸦୺࡞⏝㏵࢝ࢸࢦ࣮ࣜࠊ⏝㏵ࡢ✀㢮ࠊࡤࡃ㟢ࡢ㔜せ࡞⤒㊰㸧ࡶTD࡟グ㍕ࡍ
ࡿࡶࡢ࡜ࡍࡿ!
!
!
!
!CSRࡢ⡆᫆᭩ᘧ-----------------------------------------------------------------------------------------------------------------ࣃ࣮ࢺAࣜࢫࢡ⟶⌮ᥐ⨨ࡢᴫせࣜࢫࢡ⟶⌮ᥐ⨨ࢆᐇ᪋ࡋ࡚࠸ࡿ࡜࠸࠺ᐉゝࣜࢫࢡ⟶⌮ᥐ⨨ࢆఏ㐩ࡋ࡚࠸ࡿ࡜࠸࠺ᐉゝࣃ࣮ࢺB≀㉁ࡢ㆑ูཬࡧ≀⌮ⓗ໬Ꮫⓗᛶ≧〇㐀ཬࡧ⏝㏵ศ㢮ཬࡧ⾲♧⎔ቃ୰㐠࿨ࡢ≉ᛶே೺ᗣ᭷ᐖᛶホ౯≀⌮໬Ꮫⓗᛶ≧ࡢே೺ᗣ᭷ᐖᛶホ౯⎔ቃ᭷ᐖᛶホ౯PBT ཬࡧ vPvB ホ౯ࡤࡃ㟢ホ౯ࣜࢫࢡ≉ᛶ໬໬Ꮫ≀㉁Ᏻ඲ᛶホ౯
(CSA)

2. REACH࡟ᇶ࡙ࡃࢥ࢔࣭ࢶ࣮ࣝ! ໬Ꮫ≀㉁Ᏻ඲ᛶホ౯㸦CSA㸧ࡣỴᐃ⏝ࢶ࣮ࣝ! ໬Ꮫ≀㉁Ᏻ඲ᛶሗ࿌᭩㸦CSR㸧ࡣグ㘓࣭ᩥ᭩໬⏝ࢶ࣮࡛ࣝḢᕞ໬Ꮫ≀㉁ᗇ㸦ECHA㸧࡟ᥦฟ! Ᏻ඲ᛶࢹ࣮ࢱࢩ࣮ࢺ㸦SDS㸧ࡣᕝୗ౑⏝⪅㸦DU㸧ࡢᏳ඲࡞౑⏝ࡢࡓࡵࡢఏ㐩⏝ࢶ࣮ࣝ

CSAࡢ┠ⓗࣛ࢖ࣇࢧ࢖ࢡࣝࡢ඲ẁ㝵ࢆ㏻ࡌ࡚≀㉁1ࡢ〇㐀ཬࡧ౑⏝ࡢᏳ඲࡞≧ἣࢆ☜❧ࡍࡿ〇㐀⪅/㍺ධ⪅/ᕝୗ౑⏝⪅ࡣࡑࡢ〇㐀ཬࡧ౑⏝ࡀேࡢ೺ᗣ࡜⎔ቃ࡟ᝏᙳ㡪ࢆཬࡰࡉ࡞࠸ࡇ࡜ࢆ☜ᐇ࡟ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸1 ≀㉁ࡑࡢࡶࡢཪࡣㄪ๣ⱝࡋࡃࡣᡂᙧရ࡟ྵࡲࢀࡿ≀㉁

CSAࡢグ㍕せ௳1. ≀㉁ࡢᅛ᭷ࡢ≉ᛶே೺ᗣ ᭷ᐖᛶ㸦≀⌮໬Ꮫⓗ༴㝤ᛶ)⎔ቃ᭷ᐖᛶPBT ཬࡧ vPvB ≉ᛶ2. ࠶ࡽࡺࡿ〇㐀ཬࡧ౑⏝ࢩࢼࣜ࢜PBT =ṧ␃ᛶ䚸⵳✚ᛶ䚸ẘᛶ䠄䜢᭷䛩䜛≀㉁䠅
vPvB = ṧ␃ᛶཬ䜃⵳✚ᛶ䛜ᴟ䜑䛶㧗䛔䠄≀㉁䠅

ὀグ:ࡶࡋ≀㉁ࡀ༴㝤ᛶ1࡜ࡋ࡚ࡢศ㢮ࢡࣛ࢖ࢸࣜ࢔࡟㐺ྜࡍࡿࠊཪࡣPBTⱝࡋࡃࡣvPvB࡛࠶ࡿ࡜ホ౯ࡉࢀࡿ࡞ࡽࡤࠊ
ࡑࡢሙྜ࡟ࡣࠊ㸦CSR୰ࡢ㸧CSA࡟୍ࡘ௨ୖࡢࡤࡃ㟢ࢩࢼࣜ࢜ࠊࡤࡃ㟢᥎ᐃࠊཬࡧࣜࢫࢡ≉ᛶࢆྵࡵࡓࡤࡃ㟢ホ౯ࡶグ㍕ࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸
1 ࡍ࡞ࢃࡕࠕR࡛ࠖጞࡲࡿ࠸ࡎࢀ࠿ࡢᩥ㸦Risk Phrase㸧࡛⾲♧ࡉࢀࡿ

CSAࡢグ㍕せ௳
1. ≀㉁ࡢᅛ᭷ࡢ≉ᛶே೺ᗣ (PC)᭷ᐖᛶ
⎔ቃ᭷ᐖᛶ
PBT ཬࡧ vPvB ≉ᛶ

2. ࠶ࡽࡺࡿ〇㐀ཬࡧ౑⏝ࢩࢼࣜ࢜
3. ࣜࢫࢡ≉ᛶ໬㸸ࡤࡃ㟢ࢩࢼࣜ࢜㸦RMMࢆྵࡴ㸧࡟క࠺₯ᅾⓗ࡞ᝏᙳ㡪1࡜ࡤࡃ㟢࡟ࡼࡿᝏᙳ㡪2ࡢẚ㍑࡟ࡼࡾ
ࠊᏳ඲࡞〇㐀ཬࡧ౑⏝ࢆ♧ࡍ᪤Ꮡࡢ▱ぢࢹ࣮ࢱ᭷ᐖᛶ≉ᐃࡤࡃ㟢ࢩࢼࣜ࢜᭷ᐖࠊPBTཪࡣ vPvBClassificationand labelling࡛ࡣ࡞࠸ሙྜ᭷ᐖᛶホ౯

Exposureassessment

CSR ཬࡧSDS࡟ᩥ᭩グ㘓ࣞࢫ࣏ࣥࢩࣈ࣭ࣝࢣ࢔ཎ๎
Risk characterisation

NOAre risks adequately controlled?

!10 tpa: DNEL & PNEC

NOYES
ESs with RMM and operational conditions to adequately control the risks, to be:
Documented in the Chemical Safety Report (CSR)
Communicated to!users (to downstream users via an SDS annex)

DNEL:᥎ᐃ↓ᙳ㡪䝺䝧䝹; PNEC:↓ᙳ㡪⃰ᗘண್᪤Ꮡࡢ▱ぢ/ࢹ࣮ࢱ

CSA:

᭷ᐖᛶ≉ᐃ

ࡤࡃ㟢ࢩࢼࣜ࢜᭷ᐖࠊPBT ཪࡣ vPvB
࡛࠶ࡿሙྜ

ࡤࡃ㟢
ホ౯

᭷ᐖᛶ
ホ౯ࡤࡃ㟢

ࣜࢫࢡ≉ᛶ໬NO

Are risks adequately controlled?
ࣜࢫࢡࡀ㐺ษ࡟⟶⌮ࡉࢀ࡚࠸ࡿ࠿?

DNEL & PNEC

NOYES
ࡣ࠸
ESs with RMM and operational conditions to adequately control the risks, to be:
CSRཬࡧSDS+࡟ᩥ᭩グ㘓
Documentedin the Chemical Safety Report (CSR)
Communicated to! users (to downstream users via an SDS annex)᪤Ꮡࡢ▱㆑/ࢹ࣮ࢱCSA:᭷ᐖᛶ≉ᐃࡤࡃ㟢ࢩࢼࣜ࢜RMMཬ䜃/ཪ䛿సᴗ᮲௳䜢ಟṇ᭷ᐖࠊPBT ཪࡣ vPvB࡛࠶ࡿሙྜࡤࡃ㟢ホ౯ࡤࡃ㟢NO࠸࠸࠼᭷ᐖᛶホ౯ࣜࢫࢡ≉ᛶ໬

Are risks adequately controlled?
ࣜࢫࢡࡀ㐺ษ࡟⟶⌮ࡉࢀ࡚࠸ࡿ࠿?

DNEL & PNECNO࠸࠸࠼YESESs with RMM and operational conditions to adequately control the risks, to be:
Documented in the Chemical Safety Report (CSR)
Communicated to! users (to downstream users via an SDS annex)

CSA / ≀㉁ࡢᅛ᭷ࡢ≉ᛶ

1. ே೺ᗣ᭷ᐖᛶホ౯
2. ≀⌮໬Ꮫⓗᛶ≧ࡢே೺ᗣ᭷ᐖᛶホ౯
3. ⎔ቃ᭷ᐖᛶホ౯
4. PBTཬࡧvPvB ホ౯

CSA / ≀㉁ࡢᅛ᭷ࡢ≉ᛶ┠ⓗ㸸
1. ே೺ᗣ᭷ᐖᛶホ౯
1. ᣦ௧ 67/548/EEC࡟ᚑࡗ࡚ࠊศ㢮ཬࡧ⾲♧ࢆỴᐃࡍࡿ2. ᥎ᐃ↓ᙳ㡪ࣞ࣋ࣝ㸦DNEL㸧ࢆᑟࡁฟࡍ

2. ≀⌮໬Ꮫⓗᛶ≧ࡢே೺ᗣ᭷ᐖᛶホ౯
1. ᣦ௧ 67/548/EEC࡟ᚑࡗ࡚ࠊศ㢮ཬࡧ⾲♧ࢆỴᐃࡍࡿ3. ⎔ቃ᭷ᐖᛶホ౯
1. ᣦ௧ 67/548/EEC࡟ᚑࡗ࡚ࠊศ㢮ཬࡧ⾲♧ࢆỴᐃࡍࡿ
2. ↓ᙳ㡪⃰ᗘண ್㸦PNEC㸧ࢆᑟࡁฟࡍ

4. PBTཬࡧvPvBホ౯
1. 㝃ᒓ᭩XIIIࡢᇶ‽ࢆ≀㉁ࡀ‶ࡓࡍ࠿࡝࠺࠿ࢆỴᐃࡍࡿ
2. ࡶࡋࡑ࠺࡛࠶ࢀࡤࠊ₯ᅾⓗ࡞᤼ฟࢆ≉ᛶ໬ࡍࡿ

CSA / ᅛ᭷ࡢ≉ᛶࡢホ౯

1. ே೺ᗣ᭷ᐖᛶホ౯
2. ≀⌮໬Ꮫⓗᛶ≧ࡢே೺ᗣ᭷ᐖᛶホ౯
3. ⎔ቃ᭷ᐖᛶホ౯
4. PBTཬࡧvPvB ホ౯ࡍ࡭࡚࡟ᑐࡋ࡚ྠ୍ࡢᇶᮏ࢔ࣉ࣮ࣟࢳCSA / ᅛ᭷ࡢ≉ᛶࡢホ౯㸦㝃ᒓ᭩VI㸧1࡜2ࡢ㡰␒࡟ὀព㸟1.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷

2.

᝟ሗࡢᚲせᛶࡢ⪃ᐹ

3.

᝟ሗࢠࣕࢵࣉࡢ≉ᐃ

4.

᪂ࡋ࠸ࢹ࣮ࢱࡢసᡂ / ヨ㦂ᡓ␎ࡢᥦ᱌CSA / ᅛ᭷ࡢ≉ᛶࡢホ౯1.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷฼⏝ྍ⬟࡞ࡍ࡭࡚ࡢே೺ᗣ࣭⎔ቃ᝟ሗ:- ≀⌮໬Ꮫⓗࢹ࣮ࢱ- ேࢹ࣮ࢱ- in vitro / in vivo ࢹ࣮ࢱ- ㄞࡳྲྀࡾἲࠊSARࠊQSAR- ࡤࡃ㟢≉ᛶCSA / ᅛ᭷ࡢ≉ᛶࡢホ౯1.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷

2.

᝟ሗࡢᚲせᛶࡢ⪃ᐹ! ! 1 tpa: 㝃ᒓ᭩VII! ! 10 tpa: 㝃ᒓ᭩VIII:! ! 100 tpa: 㝃ᒓ᭩IX:! ! 1000 tpa : 㝃ᒓ᭩X:㝃ᒓ᭩XI

CSA/ ᅛ᭷ࡢ≉ᛶࡢホ౯1.
2.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷᝟ሗࡢᚲせᛶࡢ⪃ᐹ

3.

᝟ሗࢠࣕࢵࣉࡢ≉ᐃ᝟ሗࡀ௨ୗࢆᐇ᪋ࡍࡿࡢ࡟㐺ษ࡛࠶ࡿ࠿ࢆ⪃ᐹࡍࡿศ㢮࡜ࣛ࣋ࣜࣥࢢࠊ
PBTࠊvPvBࡢホ౯

DNELཬࡧPNEC
࡟ࡘ࠸࡚ࡢࢻ࣮ࢬ࣭ࢹ࢕ࢫࢡࣜࣉࢱࡢᑟฟCSA/ ᅛ᭷ࡢ≉ᛶࡢホ౯
1.
2.
3.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷᝟ሗࡢᚲせᛶࡢ⪃ᐹ᝟ሗࢠࣕࢵࣉࡢ≉ᐃ4.

᪂ࡋ࠸ࢹ࣮ࢱࡢసᡂ / ヨ㦂ᡓ␎ࡢᥦ᱌

1 ཝᐦ࡟ఱࡀ୙᫂ཪࡣ୙༑ศ࡛࠶ࡿ࠿࡟ࡘ࠸࡚⤖ㄽࢆฟࡍ
2 ヨ㦂ࡣᢏ⾡ⓗ࡟ᐇ᪋ྍ⬟࠿㸽࠸࠸࠼ࡣ࠸3 ࡤࡃ㟢࣮࣋ࢫࡢච㝖ࢆ㐺⏝࡛ࡁࡿ࠿㸽ࡣ࠸ヨ㦂ࢆᐇ᪋ࡋ࡞࠸ṇᙜ࡞⌮⏤ࢆ♧ࡍ

! 1 tpa: ➨2ิࡢ≉ᐃつ๎ࢆཧ↷! 10 tpa: ࡉࡽ࡟㝃ᒓ᭩ XIࡶཧ↷CSA/ ᅛ᭷ࡢ≉ᛶࡢホ౯
1.
2.
3.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷᝟ሗࡢᚲせᛶࡢ⪃ᐹ᝟ሗࢠࣕࢵࣉࡢ≉ᐃ

4.

᪂ࡋ࠸ࢹ࣮ࢱࡢసᡂ / ヨ㦂ᡓ␎ࡢᥦ᱌

1 ཝᐦ࡟ఱࡀ୙᫂ཪࡣ୙༑ศ࡛࠶ࡿ࠿࡟ࡘ࠸࡚⤖ㄽࢆฟࡍ! 1tpa ཬࡧ < 10 tpa: 㝃ᒓ᭩VIIཧ↷! 10 tpa: ࢚ࣥࢻ࣏࢖ࣥࢺࡈ࡜ࡢITSཧ↷(RIP3.3)

2 ヨ㦂ࡣᢏ⾡ⓗ࡟ᐇ᪋ྍ⬟࠿㸽ࡣ࠸

3 ࡤࡃ㟢࣮࣋ࢫࡢච㝖ࢆ㐺⏝࡛ࡁࡿ࠿㸽࠸࠸࠼

4 in vitro ヨ㦂ࡀ㐺ษ࡛࠶ࡿ࠿࡝࠺࠿᳨ウࡍࡿ

ࡣ࠸

࠸࠸࠼

5 㐺ษ࡞in vivoヨ㦂ࢆᐇ᪋ཪࡣᥦ᱌ࡍࡿࡣ࠸

ヨ㦂ࡢᐇ᪋
ཪࡣ
ᢎㄆᚅࡕ

CSA/ ᅛ᭷ࡢ≉ᛶࡢホ౯(㝃ᒓ᭩VI)1.

฼⏝ྍ⬟࡞᝟ሗࡢ཰㞟࡜ඹ᭷

2.

᝟ሗࡢᚲせᛶࡢ⪃ᐹ

3.

᝟ሗࢠࣕࢵࣉࡢ≉ᐃ

4.

᪂ࡋ࠸᝟ሗࢠࣕࢵࣉࡀᇙࡲࡗࡓ࠿㸽᪂ࡋ࠸ࢹ࣮ࢱࡢసᡂ / ヨ㦂ᡓ␎ࡢᥦ᱌᪤Ꮡࡢ▱ぢ/ࢹ࣮ࢱCSA:Exposure scenarios?

᭷ᐖᛶ≉ᐃ᭷ᐖࠊPBT ཪࡣ vPvB࡛࠶ࡿሙྜ᭷ᐖᛶホ౯

Exposureassessment

Risk characterisation

NOAre risks adequately controlled?

!10 tpa: DNELཬࡧPNECNO

YES
ESs with RMM and operational conditions to adequately control the risks, to be:
Documented in the Chemical Safety Report (CSR)
Communicated to!users (to downstream users via an SDS annex)ศ㢮ཬࡧ⾲♧ᇶ‽㸦ࢡࣛ࢖ࢸࣜ࢔㸧
ᣦ௧67/548/EEC࡟‽ᣐREACH

RIP 3.61໬Ꮫ≀㉁ࡢศ㢮ཬࡧ⾲♧࡟㛵ࡍࡿୡ⏺ㄪ࿴ࢩࢫࢸ࣒㸦GHS㸧
㸦෌ศ㢮ࡢᮇ㝈㸸2010ᖺ12᭶1᪥㸧
1 ࡲࡔጞືࡋ࡚࠸࡞࠸

PBTཬࡧvPvB ホ౯ᇶ‽㸦TGD RIP 3.2ཧ↷㸧
PBT ᇶ‽

ࣃ࣓࣮ࣛࢱP༙ῶᮇ㸦௨ୗࡢ࠸ࡎࢀ࠿㸧㸸> 60᪥㸦ᾏỈ୰> 40᪥㸦ῐỈ୰ཪࡣỶỈ୰㸧
> 180᪥㸦ᾏᗏሁ✚≀୰㸧
> 120᪥㸦 ῐỈཪࡣἙཱྀࡢሁ✚≀୰㸧vPvB ᇶ‽༙ῶᮇ㸦௨ୗࡢ࠸ࡎࢀ࠿㸧㸸> 60᪥㸦 ᾏỈࠊῐỈࠊཪࡣ ỶỈ㸧> 180᪥㸦ᾏᗏࠊῐỈࠊཪࡣ Ἑཱྀࡢሁ✚≀୰㸧
> 180᪥(ᅵተ୰㸧> 120᪥(ᅵተ୰㸧B

BCF > 2000

BCF >5000T

៏ᛶNOEC < 0.01 mg/l ཪࡣ C㸦༊ศ1, 2㸧M 㸦༊ศ1, 2㸧 R 㸦༊ศ1-3㸧ཪࡣෆศἪ࠿ࡃ஘ᙳ㡪ヱᙜ࡞ࡋ

T-R48 ཪࡣ Xn-R48

DNEL ᑟฟNOAELDNEL=⥲ᣓ䜰䝉䝇䝯䞁䝖ಀᩘ1ࢹ࣮ࢱ
NOAEL(↓ẘᛶ㔞)㸸 28᪥㛫ࠊ90᪥㛫ⱝࡋࡃࡣ2ᖺ㛫ࡢ཯᚟ᢞ୚ヨ㦂ཪࡣ⏕Ṫẘᛶヨ㦂࠿ࡽᚓࡽࢀࡓᝏ࠸ᙳ㡪ࡀぢࡽࢀ࡞࠸᭱኱⏝㔞
AF㸦࢔ࢭࢫ࣓ࣥࢺಀᩘ㸧㸸ື≀࠿ࡽே㛫࡟⮳ࡿࡲ࡛ࡢᵝࠎ࡞ᮍ▱ࡢᙳ㡪ࡢ᥎ᐃࡢࡓࡵ࡟⏝࠸ࡽࢀࡿಀᩘ࡛ࠊලయⓗ࡟ࡣ௨ୗࡢ࡜࠾ࡾࠋ࢔ࢭࢫ࣓ࣥࢺಀᩘ㸦AF㸧
AF1✀㛫
AF2✀ෆ
AF3ᮇ㛫AFn⏝㔞཯ᛂ 㸦౛࠼ࡤ LOAELࡢࡳ㸧
AFmࢹ࣮ࢱ࣮࣋ࢫࡢ㉁1 ⥲ᣓ࢔ࢭࢫ࣓ࣥࢺಀᩘ = AFᩘ್
105 㸦ປാ⪅㸧10 㸦୍⯡㸧2̺61 ̺ ⣙3!11 ! AF2 ! AF3 ! AF4 ! !!

PNEC ᑟฟ㸦Ỉ⣔㸧P PNEC = L(E)C50ࠊNOECࠊ HC5 䠄᭱ప್䠅
AFAFAF NECNECࢹ࣮ࢱ࢔ࢭࢫ࣓ࣥࢺಀᩘ

࣮࣋ࢫࢭࢵࢺ㸦㨶㢮ࠊ࣑ࢪࣥࢥཬࡧ⸴㢮㸧ࡢ3ᰤ㣴ẁ㝵ࡑࢀࡒࢀ࠿ࡽᑟฟࡉࢀࡿ▷ᮇL(E)C50㏣ຍ
1௳ࡢ㛗ᮇNOEC㸦㨶㢮ཪࡣ࣑ࢪࣥࢥ㸧

1000

1002ᰤ㣴ẁ㝵ࡢ✀ࢆ⏝࠸ࡓ2௳ࡢ㛗ᮇNOECs
㸦㨶㢮ཬࡧ/ཪࡣ࣑ࢪࣥࢥཬࡧ/ཪࡣ⸴㢮㸧

503ᰤ㣴ẁ㝵ࡢ3✀௨ୖࢆ⏝࠸ࡓ㛗ᮇNOECs
㸦㏻ᖖࡣ㨶㢮ࠊ࣑ࢪࣥࢥཬࡧ⸴㢮㸧

10✀ࡢឤཷᛶศᕸ㸸 HC5ࣇ࢕࣮ࣝࢻࢹ࣮ࢱཪࡣࣔࢹࣝ⏕ែ⣔
L(E)C50䠖༙ᩘ⮴Ṛ⃰ᗘ

NOEC䠖↓ᙳ㡪⃰ᗘ5-1ࢣ࣮ࢫࣂ࢖ࢣ࣮ࢫ

6. REACH࢞࢖ࢲࣥࢫཬࡧࢶ࣮ࣝ

" RIP 1: ࣉࣟࢭࢫㄝ᫂
" RIP 2: REACH-ITࡢ㛤Ⓨ" RIP 3: ⏘ᴗ⏺ࢆᑐ㇟࡜ࡍࡿ࢞࢖ࢲࣥࢫ㈨ᩱ
- 3.1 TDసᡂ࡟㛵ࡍࡿTGD- 3.2 CSR సᡂ࡟㛵ࡍࡿTGD1- 3.3 ᝟ሗせ௳ཬࡧᅛ᭷ࡢ≉ᛶ࡟㛵ࡍࡿTGD- 3.6 GHS࡟ᇶ࡙ࡃศ㢮ཬࡧ⾲♧࡟㛵ࡍࡿGD2" RIP 4: 㛵ಀᙜᒁࢆᑐ㇟࡜ࡍࡿ࢞࢖ࢲࣥࢫ㈨ᩱ
" RIP 5/6: ໬Ꮫ≀㉁ᗇࡢタ❧1 ࡲࡔ᭱⤊໬ࡉࢀ࡚࠸࡞࠸2ࡲࡔ㛤ጞࡉࢀ࡚࠸࡞࠸