Department of Macromolecular
Science

Department ofMacromolecular Science

Department ofMacromolecular Science

Macromolecular Science was born in the middle of the lastcentury and made rapid progress in the last several decades to fill thegap between traditional disciplines and meet the practical needs ofthe new era. However, macromolecular science is not a mereextension of chemistry or physics but stands at the crossroads ofchemistry, physics, and life science. Especially macromolecularscience has been regarded as an important field of science for theunderstanding of biological phenomena at a molecular level.
Macromolecules are known as a typical complex system and haverecently attracted the great interest of many scientists in the field ofphysics. Thus, macromolecular science must be one of the mostimportant fields of natural science in this new century.
There are several universities having departments ofmacromolecular science in Japan. However, the department ofmacromolecular science of Osaka University is unique in the sensethat it belongs to the graduate school of science. The others belong to
the faculty of engineering, aiming at practical applications. This
indicates that the objective of our department is basic research on
macromolecules. The department consists of four major researchgroups: there are a total of twelve laboratories covering major
subjects of macromolecular science as described below. The staffs ofeach laboratory are famous over the world.
The department is active in international exchange. Many leading
scientists of macromolecular science visit our department. The
department organizes the international symposium named "Osaka
University Macromolecular Symposium" (OUMS) every two or
three years. Of course, there are many international students.
The macromolecular science course devotes itself to training
graduate students by offering a systematic lecture course in
macromolecular chemistry and physics. It also guides students bymakingthem engaged in basic research at one of the ten laboratories.
高分子凝集系科学講座
Through their graduate studies, students acquire various professional
knowledge and techniques leading to the degrees of the master or
doctor of science.

Research Group ofPolymer Synthesis and Reaction Chemistry
In order to create new polymer materials with special functions
and/or excellent properties, similar to biopolymers, the Laboratoryof Polymer Synthesis aims to investigate new ideas and methods
which allow us to control the structure and the molecular weight ofthese polymers in a precise manner. For example, this group could
find out the highly selective living polymerization system with noside reactions through the research on the cationic polymerization
reaction mechanism. As a result, it is now possible to produce
various types of polymers such as polymers with homogeneous
chain length and structure, polymers with special shape or uniqueproperties, polymers which are highly sensitive to external stimulus,etc.
In the Laboratory of Macromolecular Reaction Chemistry, awide variety of studies on syntheses and functionalization ofmacromolecules has been done based on macromolecularscience, coordination chemistry and organometallic chemistry.
Unique reactivity of metal complexes is applied to developmentof a new polymerization catalyst and precise
design ofmacromolecular complexes. Metalloenzyme can be recognized asa representative example of functional
biomacromolecules
incorporating metal complexes. To understand the mechanismof metalloenzyme function, synthesis and structuralcharacterization of a model of active site and non-natural
peptides are investigated.

Research Group of Structure, Function,
and Properties of Polymers
Polymer chain molecules have a large number of internal degrees of
freedom and sometimes form higher-order structures. They can easily
respond to the change of external fields such as mechanical and electricfields by changing their internal structures. This is a common feature of“soft matters,” including micellae, liquid crystals, supramolecules, andso on. The laboratory of Polymer Physical Chemistry investigatesphysicochemical and rheological properties of soft matters throughviscoelastic, dielectric, rheo-optical, and nuclear magnetic resonancerelaxation measurements in order to elucidate the nature ofmacromolecules.
Molecular recognition by macromolecules plays an important role,for example, in substrate specificity of enzymes and antigenantibody reactions in human life. Selective molecular recognition
among macromolecules is achieved through a large number of weakinteractions. The Laboratory of SupramolecularFunctional
Chemistry constructs functionalized sensing, catalytic, and energy
conversion systems by utilizing monoclonal antibodies.
Synthesis of macromolecules with well-defined chemical
structures (i.e., precise macromolecules) has been one of important
challenges in macromolecular science. The
Laboratory of
Macromolecular Precise Science strives to construct a new type ofprecise macromolecules with specific primary structures. Various
properties of these precise macromolecules, e.g., hydration andassociation properties, are investigated to understand the nature ofmacromolecules (i.e., macromolecularity) in more detail. This
laboratory also aims at creation of high-performance macromolecules
comparative tobiological macromolecules using the precise
macromolecules.
Laboratory of polymeric materials design: Tough and flexible
polymeric materials are used in various manufacturing industries andhealthcare applications. However, polymeric materials are brittle andeasily broken when concentrated external stress is applied to thematerial. To enhance their mechanical strength, materials scientists
have improved polymeric, we investigated innovative polymericmaterials design using host-guest interactions between cyclodextrin(CD) and hydrophobic guest molecules via supramolecular reversible
bonds. We found a variety of supramolecular polymeric materials,
such as macroscopic self-assemblies, self-healing materials, artificial
muscles, and shape memory materials. We prepared tough andflexible bulk polymeric materials by using various hydrophobic
acrylates modified with CD hosts or guests. The obtained polymers
have host and guest moieties as their side chains to form elastomers
with high flexibility and toughness.

Research Group of
Macromolecular Assemblies
Any small change in the primary structure may lead to someserious effect on its higher structural hierarchy. For example, lack ofvitamin C causes the fatal disease “scurvy” because that stops
formation of normal collagen fiber. That is, without vitamin C, nohydroxylation of proline takes place and thereby no further
stabilization of collagen fiber. The Laboratory of Macromolecular
Structure aims to elucidate the relationship between structure andphysical properties (or functions) of macromolecules at atomic
resolution using X-ray diffraction, neutron scattering and infrared andRaman spectroscopy.

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory of polymeric materials design: Tough and flexible
polymeric materials are used in various manufacturing industries andhealthcare applications. However, polymeric materials are brittle andeasily broken when concentrated external stress is applied to thematerial. To enhance their mechanical strength, materials scientists
have improved polymeric, we investigated innovative polymericmaterials design using host-guest interactions between cyclodextrin(CD) and hydrophobic guest molecules via supramolecularreversible bonds. We found a variety of supramolecular polymericmaterials, such as macroscopic self-assemblies, self-healingmaterials, artificial muscles, and shape memory materials. We
prepared tough and flexible bulk polymeric materials by using
various hydrophobic acrylates modified with CD hosts or guests.
The obtained polymers have host and guest moieties as their side
chains to form elastomers with high flexibility and toughness.

Research Group of Informative Polymer
Science
The aim of the Laboratory of Cryo-EM Structural Biology is toclarify the mechanisms of molecular machines based on the
structural analysis by cryo-EM. The cryo-EM is one of the structural
analysis methods, that has been drawing attention in recent years,
and we are developing high-resolution structural analysis methods
and techniques. We are elucidating the energy conversion
mechanism of molecular motors and analyzing the structure ofolfactory receptors by using these technologies.
Laboratory of Protein Crystallography was established in 1959 toelucidate the molecular structure of proteins by X-ray
crystallography. Nowadays the combination of X-ray and Cryo-EM
technique has become the most powerful way to determine protein
structures. One of our aim is to spread the application of this method
throughout biological science. Current research projects arefocused on biological macromolecular assemblies and membraneproteins. Especially, our lab is interested in studying the structureand function of biological energy transducing proteins, such as
photosynthetic electron transfer complex and microtubule dynein
motor.
The
aim of the Laboratory of Supramolecular Crystallography
高分子凝集系科学講座
is to elucidate the structure of biological macromolecules andbiological macromolecular assemblies to understand their functions
based on the atomic structures. X-ray crystallography is one of themost powerful tools for structure determination of biologicalmacromolecules and biological macromolecular assemblies, andwe are also working on the development of new technologies andmethodologies of protein crystallography, including the synchrotron
radiation beamline at SPring-8.

Department of Environment and Safety

Laboratory of Chemistry for Environment and Safety: Li ion
battery has now become a fundamental device in our daily life.
However, the use of organic solvents and very high energy density
in Li ion batteries introduce the battery include dangerous hazards
such as ignition accidents. In this laboratory, we are developing a
new class of solid polymer electrolytes, named low-barrier ion
conductive polymer electrolytes, for Li ion batteries to realize thesafety of these batteries. In addition, this laboratory aims at
developing new photo-chemical energy conversion system. As thelaboratory belongs to the department for the administration of safety
and hygiene, we carry out the research projects to contribute to thesafety of science and technology, together with the activity for
maintaining the safety level of university research work andexperiments.

Home Page
http://www.chem.sci.osaka-u.ac.jp/graduate/mms/en/index.html

E-mail Addresses of the Staffs
Laboratory of Polymer Synthesis
Sadahito AOSHIMA

Professor

aoshima chem.sci.osaka-u.ac.jp
Associate Professor
kanazawaall chem.sci.osaka-u.ac.jp
Laboratory of Macromolecular Reaction Chemistry
Kiyotaka ONITSUKA
Professor
onitsuka chem.sci.osaka-u.ac.jp
Taka-aki OKAMURA
Associate Professor
tokamura chem.sci.osaka-u.ac.jp
Naoya KANBAYASHI
Associate Professor
naokou chem.sci.osaka-u.ac.jp
Laboratory for Polymer Physical Chemistry
Tadashi INOUE
Professor
tadashi chem.sci.osaka-u.ac.jp
Osamu URAKAWA
Associate Professor
urakawa chem.sci.osaka-u.ac.jp
Laboratory of Supramolecular Functional Chemistry
Hiroyasu YAMAGUCHI
Professor
hiroyasu chem.sci.osaka-u.ac.jp
Yuichiro KOBAYASHI
Assistant Professor
kobayashiy11 chem.sci.osaka-u.ac.jp
Laboratory of Macromolecular Precise Science
Akihito HASHIDZUMEProfessor
hashidzume chem.sci.osaka-u.ac.jp
Masaki NAKAHATA
Assistant Professor
nakahata chem.sci.osaka-u.ac.jp
Laboratory of Polymeric Materials Design
Yoshinori TAKASHIMA
Professor
takasima chem.sci.osaka-u.ac.jp
Ryohei IKURASpecially Appointed Assistant Professor
ikurar16 chem.sci.osaka-u.ac.jp
Kenji YAMAOKA
Specially Appointed Assistant Professor
yamaokak23 chem.sci.osaka-u.ac.jp
Laboratory of Macromolecular Structure
Katsumi IMADA
Professor
kimada chem.sci.osaka-u.ac.jp
Fumitoshi KANEKO
Associate Professor
toshi chem.sci.osaka-u.ac.jp
Tatsuya KAWAGUCHI
Lecturer
kguchi chem.sci.osaka-u.ac.jp
Norihiro TAKEKAWA
Assistant Professor
takekawan16 chem.sci.osaka-u.ac.jp
Laboratory of Macromolecular Solutions
Ken TERAO
Professor
kterao chem.sci.osaka-u.ac.jp
Laboratory of CryoEM Structural Biology (Institute for Protein Research)
Takayuki KATO
Professor
tkato protein.osaka-u.ac.jp
Jun-ichi KISHIKAWA
Assistant Professor
kishi.jun protein.osaka-u.ac.jp
Hiroko TAKAZAKI
Assistant Professor
takahiro protein.osaka-u.ac.jp
Mika HIROSE
Specially Appointed Researcher
mhirose protein.osaka-u.ac.jp
Kiyo TUNEZUMISpecially Appointed Researcher
kiyotune protein.osaka-u.ac.jp
Laboratory of Protein Crystallography (Institute for Protein Research)
Genji KURISU
Professor
gkurisu protein.osaka-u.ac.jp
Hideaki TANAKA
Associate Professor
tana protein.osaka-u.ac.jp
Akihiro KAWAMOTO
Assistant Professor
kawamoto protein.osaka-u.ac.jp
Naoko NORIOKA
Technical Assistantnaoko protein.osaka-u.ac.jp
Laboratory of Supramolecular Crystallography (Institute for Protein Research)
Atsushi NAKAGAWA
Professor
atsushi protein.osaka-u.ac.jp
Mamoru SUZUKI
Associate Professor
mamoru.suzuki protein.osaka-u.ac.jp
Eiki YAMASHITA
Associate Professor
eiki protein.osaka-u.ac.jp
Makoto MATSUDA
Specially Appointed Asssistant Professor
mmatsuda protein.osaka-u.ac.jp
Laboratory of Chemistry for Environment and Safety(Department of Safety and Hygiene)
Hitoshi YAMAMOTO
Professor
jin chem.sci.osaka-u.ac.jp
Hideki MOMOSEAssociate Professor
momose mat.eng.osaka-u.ac.jp
Arihiro KANAZAWA

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory of Polymer Synthesis
Members

Sadahito AOSHIMA (Professor), Arihiro KANAZAWA (Associate Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/aoshima/［Research Projects］
Recently, well-designed stimuli-responsive polymers haveattracted much interest as precursors of advanced polymer
materials such as nano-organized self-assemblies, intelligent
hydrogels, and DDS. In particular, recent progress in living
polymerization has encouraged us to design various types of block
copolymers in order to examine their stimuli-induced selfassociation. We have prepared a variety of functional polymers
with well-controlled structures and molecular weights by living
cationic polymerization in the presence of an added base. On thebasis of these results, we have designed a new strategy for
preparing block copolymers with various types of stimuliresponsive properties such as thermosensitive physical gelation.
[Research Area]
1) Syntheses of well-defined polymers with various characteristic
properties by living cationic polymerization.
2) Syntheses of advanced stimuli-responsive block copolymers.
3) Investigation of polymerization mechanism and design of novel
living polymerization.

Concept of macromolecular design and living polymerization
for synthesis of well-designed stimuli-responsive polymers

Laboratory of
Macromolecular Reaction Chemistry
Members

Kiyotaka ONITSUKA (Professor), Taka-aki OKAMURA (Associate Professor),
Naoya KANBAYASHI (Assistant Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/onitsuka/en/
1)［Research Area］
Our research involves the development of new polymer
synthesis and functionalization incorporating a characteristicfeature of metal elements. For example, precise design of newtransition metal complexes and investigation of their reactivity
lead to the development of new polymerization catalysts.
Functionalization of polymers based on the control of organic
synthesis. Our research interest is also focused on metalloenzyme.
Model complexes of active sites and non-natural peptide aredesigned and structurally characterized.

2)
3)

4)

Development of new organometallic polymerization catalysts
and their application to synthesis of functional polymers
Functional macromolecular complexes composed oforganometallic units
Investigation of the reactivity controlling mechanism in theactive center of metalloenzyme using model complexes
having simple ligands and/or short peptides.
Synthesis of non-natural amino acid polymers for higher
order structure formation and expression of novel functions.

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory for Polymer Physical
ChemistryMembers

Tadashi INOUE (Professor), Osamu URAKAWA (Associate Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/inoue/index_e.html［Research Interests］
1)
2)
3)
4)
5)
6)
7)

Shear-induced structures of soft matters.
Nonlinear rheology and rheo-optics of polymer solids.
Molecular motions of hyper-branched polymers.
Structure and molecular motions of supramolecules.
Hydration and molecular motions of water-soluble polymers.
Structure and dynamics of polymer composites.
Entanglement of semiflexible polymers.

The term “soft matter” stands for soft materials which form amesoscopic structure much larger than atoms, including polymers,
liquid crystals, suspension, and self-assembling molecules. Softmatters are actually “soft,” and they can efficiently respond to external
fields like strain fields, flow fields, electric fields, and so on. They
sometimes show drastic structural changes. We have studied theirunique physicochemical properties, particularly nonlinear responses
under strong external fields, including their fruitful equilibrium
properties and dynamics. We have focused on the molecularinterpretation of rheological phenomena of polymers and micellae as amodel system of soft matter.

Laboratory of SupramolecularFunctional Chemistry
Members

Hiroyasu YAMAGUCHI (Professor), Yuichiro KOBAYASHI (Assistant Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/yamaguchi/english/index.html［Research Interests］
1) Development of a high performance sensing element.
2) Construction of energy conversion and catalytic systems using
hybrids of biomacromolecules with synthetic molecules.
3) Creation of functionalized supramolecular materials based on selfassembly of bio-related and/or synthetic polymers.
In biological systems, life processes are led by the unique behaviorof macromolecules such as proteins and DNA. Molecular recognitionby macromolecules plays an important role, for example, in substratespecificity of enzymes and antigen-antibody reactions in human life.
Selective molecular recognition among macromolecules is achieved
through a large number of weak interactions. We have focused ourattention on the special behavior of antibodies, especially monoclonal
antibodies, because they can recognize a larger and more complex
compound with high specificity. In this laboratory, we develop novel
supramolecular materials and construct functionalized sensing,catalytic, and energy conversion systems via specific molecular
recognition of biomacromolecules and selective assembly of
bio/synthetic molecules.

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory of Macromolecular Precise Science
Members

Akihito HASHIDZUME (Professor) ), Masaki NAKAHATA (Assistant Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/hashidzume/index_eng.html

Macromolecular substances are ubiquitous, and these substances
enrich our lives. Our bodies are also composed of macromolecules,e.g., nucleic acids and proteins. To unravel the reasons behind whylife has chosen macromolecules as essential building blocks, andto elucidate the crucial roles that macromolecules play in our life,
we devote our efforts to understand the nature of macromolecules,
i.e., macromolecularity using precise macromolecules. We also
aim at the creation of high-performance macromolecules based on
macromolecularity. We are thus carrying out the following threeprojects.

3) Creation of High-Performance Macromolecules
We challenge existing boundaries to creation ofhigh-performance macromolecules comparative tobiological macromolecules using the precise
macromolecules.

[Research Projects]
1) Creation of Precise Macromolecules
We synthesize precise macromolecules with well-definedchemical structures because these precise macromolecules are
critical for deeper understanding of macromolecularity.
2) Understanding of Macromolecularity
We strive to understand macromolecularity utilizing the precise
macromolecules.

Laboratory of Polymeric Materials Design[Research Area]

Members

Yoshinori TAKASHIMA (Professor), Ryohei IKURA (Specially Appointed Assistant Professor)
Kenji YAMAOKA (Specially Appointed Assistant Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/takashima/

Tough and flexible polymeric materials are used in various manufacturing industries
and healthcare applications. However, polymeric materials are brittle and easily broken
when concentrated external stress is applied to the material. To enhance theirmechanical strength, materials scientists have improved polymeric, we investigatedhost-guest interactions between cyclic molecules and hydrophobic guest molecules via
supramolecular reversible bonds. We found a variety of supramolecular polymericmaterials, such as macroscopic self-assemblies, self-healing materials, artificial
muscles, and shape memory materials. We prepared tough and flexible bulk polymericmaterials by using various hydrophobic acrylates modified with cyclic molecules hosts
or adamantane guests. The obtained polymers have host and guest moieties as theirside chains to form elastomers with high flexibility and toughness.
Research topics.
(1) Creation of polymeric materials with reversible bonding.
(2) Creation of polymer materials with movable cross-linking(3) Creation of polymeric materials combining reversible and movable cross-linking.
(4) Creation of stimuli-responsive polymeric materials(5) Creation of polymeric materials combining natural and synthetic polymers.

AdhesionStretching

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory of Macromolecular StructureMembers

Katsumi IMADA (Professor), Fumitoshi KANEKO (Associate Professor),
Tatsuya KAWAGUCHI (Lecturer), Norihiro TAKEKAWA (Assistant Professor)

Home Page

http://www.chem.sci.osaka-u.ac.jp/lab/imada/en/index.html[Research Area]
Biological process is driven by complex molecular machines composed of
biological macromolecules. The flagellum, which is an organelle for bacterial
motility, is one of those molecular machines. The flagellum is a huge protein
assembly composed of a helical filamentous screw, a molecular universal joint,a highly efficient ion-driven motor and a protein export apparatus for selfconstruction. The Laboratory of Macromolecular Structure aims to provide
fundamental understanding of operating principles and the self-assembly
mechanism of biological macromolecular machines, such as the bacterial
flagellum, through the studies of molecular structure at atomic resolution andreconstitution of the molecular machines. We also study structures of polymer
complexes with low molecular weight compounds and the relationship between
their structures and functions.
1)
Rotation mechanism of bacterial motor systems.
2)
Self-constitution mechanism of bacterial motility machines.
3)
Structural and functional studies on bacterial infection apparatus.
4)5)Structural and functional studies on environmental sensing units.
Study on the structure of polymer complex with small molecule andits formation mechanism.

Schematic drawing of the bacterial hook basal-bodyarchitecture

Laboratory of Macromolecular Solutions
Members Ken TERAO (Professor)
Home Page

https://www.chem.sci.osaka-u.ac.jp/lab/terao/[Research Area]
Macromolecules in solution can take a nearly infinite number ofconformations due to their high degree of freedom of internal rotations.
Macromolecules in solution have, therefore, specific characteristics notfound in small molecules. Intramolecular interactions in a macromoleculeand intermolecular interactions with solvent molecules significantly
influence the molecular shape in solution. Furthermore, strong
intramolecular interactions, including hydrogen bonding and electrostaticinteractions, lead to the formation of micelles and aggregates. Theintermolecular interactions between polymers through solvents can also
cause various phase separations. Such phenomena correlate with thefunctions in biosystems. Our research aim is to clarify the various
phenomena exhibited by macromolecules in solution, that is, single chain
conformation, complex formation behavior, and phase separation
behavior by using the latest scattering and spectroscopic methods.
[Research Projects]
1) Conformation and molecular recognition ability of polysaccharides
and their derivatives
2) Molecular conformation and intermolecular interactions of ring andbranched polymers
3) Aggregation and phase separation of branched polymers-poor solvent
systems4) Complex formation of polymers with nanoparticles

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory of CryoEM Structural Biology(Institute for protein research)

Members

Takayuki KATO (Professor), Jun-ichi KISHIKAWA (Assistant Professor),
Hiroko TAKAZAKI (Assistant Professor)

Home Page

http://www.protein.Osaka-u.ac.jp/cryoem/index.html[Research Interests](1) Study of energy conversion mechanism of molecular motor(2) Structural analysis of olfactory receptors(3) Study of molecular dynamics by cryo-electron microscope(4) Development of high-resolution structural analysis method by cryo-electron
microscope
The biomolecules such as protein and nucleotide are responsible for life activity, its
function is relative to the structure. In our laboratory, we will clarify the molecularmechanism by structural analysis using a cryo-EM. In particular, we are analyzing theenergy conversion mechanism of motor protein such as flagellar motors and ATPase, andthe mechanism of olfactory receptors. We are also developing of the method for analysis ofmolecular dynamics by cryo-EM and for high-resolution and high-resolution structural
analysis by cryo-EM.

Structure of Flagella Hook

Cryo-EMs

Laboratory of Protein Crystallography(Institute for Protein Research)

Members

Genji KURISU (Professor), Hideaki TANAKA (Associate Professor),
Akihiro KAWAMOTO (Assistant Professor), Naoko NORIOKA (Technical Assistant)

Home Page

http://www.protein.osaka-u.ac.jp/crystallography/EngHP/[Research Interests]
1)
2)
3)

Structural studies of photosynthetic energy-transducing membraneprotein complex and related redox enzymes
Crystal structure analyses of dynein motor
Damage-free crystal structure analysis of metalloproteins at highresolution

Three-dimensional protein structure brings us a deeper insight into the
biological function. X-ray crystallography combined with Cryo-TEM isthe best method to determine atomic coordinates of protein molecules.
The main aim of our group is the structure determination of the biologicalmacromolecular assemblies including membrane protein complexes, inorder to elucidate the molecular mechanism of the highly organizes
biological process at atomic level.

Crystal Structure of the dynein motor domain

Graduate School of Science
2023-2024

Department of Macromolecular
ScienceLaboratory for Supramolecular
Crystallography (Institute for Protein Research)
Members

Atsushi NAKAGAWA (Professor), Mamoru SUZUKI (Associate Professor), Eiki YAMASHITA(Associate Professor), Makoto MATSUDA (Specialy Appointed Assistant Professor)

Home Page

http://www.protein.osaka-u.ac.jp/rcsfp/supracryst/en/[Current Research Projects]
1) X-ray structure determination of biological macromolecularassemblies and proteins.
2) Development methodologies for X-ray structure determination of
biological macromolecular assemblies using synchrotron
radiation and X-ray free electron laser.
3) Development of tools for structural biology.
Macromolecule assemblies, consisting of proteins, nucleic
acids, and other substances, play key roles in all living system. Ourlaboratory works on structure determination of biologicalmacromolecular assemblies using X-ray diffraction technique.
Development of tools for X-ray crystallography of biologicalmacromolecular assemblies, including the synchrotron radiation
beamline at SPring-8, is also our main works.

Multi-drug Efflux Pump Complex
from Pseudomonas aeruginosa

Laboratory of Chemistry for Environment
and Safety(Department of Safety and Hygiene)

Members

Hitoshi YAMAMOTO (Professor), Hideki MOMOSE (Associate Professor)

Home Page

http://www.osaka-u.ac.jp/jp/facilities/anzen/kankyou/[Research Area]
1)
2)
3)
4)
5)

Development of low barrier ion conductive polymer electrolytes.
Development of the photo-switching functional molecules.
Development of detection methods for environmental chemicals.
Construction of education system for realization of safety conscious
culture in the university.
Research and analyses of university accidents in the world.

This laboratory belongs to department of safety and hygiene, whose
mission is managing safety and hygiene of all people constituting theuniversity. The research in this laboratory aims to contribute to the safetyof wide area in science and technology.
At present, our research projects focus on development of new functional
molecules such as low barrier ion conductive polymers for the safety of Li
ion batteries, photo-switchable hydrogen bonds for environmental
chemistry, etc.
In addition, our laboratory proposes safe methods and techniques for
conducting research and experiments through investigation and analyses ofuniversity accidents in the world.

Graduate School of Science
2023-2024