The 15th International Symposium of the Institute Network for Biomedical Sciences
The 6th IMCR Symposium on Endocrine and Metabolism

Cutting Edge of Biomedical and Metabolic Sciences
Institute for Molecular and Cellular Regulation, Gunma University

November 5 - 6, 2020
To be held online

Thursday, November 5, 2020
09:00-09:05

Opening Remarks
Ken Sato (Director of Institute for Molecular and Cellular Regulation,Gunma University)

Keynote Lecture 1
Chairs:Ken Sato(Institute for Molecular and Cellular Regulation, Gunma University)

09:05-09:45

Fumio Motegi (National University of Singapore, Singapore)
Design principles of self-organizing cell polaritySession 1:

Epigenetic and Transcriptional Regulations

Chair:

Izuho Hatada

09:45-10:10

S-01: Shiroh Iwanaga (Research Institute for Microbial Diseases, OsakaUniversity)
Transcriptional regulation of Plasmodium parasite

10:10-10:35

S-02: Fan-Yan Wei (Institute of Development, Aging and Cancer, Tohoku
University)
Emerging crosstalk between RNA epitranscriptome and extracellularsignaling

10:35-11:00

S-03: Ken-ichi Noma (Institute for Genetic Medicine, Hokkaido University)
3D genomic basis of cellular senescence

11:00-11:15

O-01: Motohiko Oshima (The Institute of Medical Science, The Universityof Tokyo)
Profiling of chromatin accessibility of aged hematopoietic stem cells

11:15-11:30

Break(Institute for Molecular and Cellular Regulation, Gunma University)

Short-talk Session for Young Researchers 1
Chairs:Yuhkoh Satouh (Institute for Molecular and Cellular Regulation, Gunma University)
Takuro Horii (Institute for Molecular and Cellular Regulation, Gunma University)

11:30-11:38

Y-01: Manabu Kodama (Medical Institute of Bioregulation, Kyushu
University)
A shift in glutamine nitrogen metabolism contributes to the malignant
progression of cancer

11:38-11:46

Y-02: Akihito Sakoguchi (Research Institute for Microbial Diseases, OsakaUniversity)
Immune activating receptors specific to Plasmodium falciparum-infected redblood cells

11:46-11:54

Y-03: Yusuke Takagi (The Institute of Medical Science, The University ofTokyo)
Identification and functional analysis of a novel gene that is induced byhyperactivation of the ERK pathway

11:54-12:02

Y-04: Kazumasa Takemoto (Institute of Molecular Embryology andGenetics, Kumamoto University)
Meiotic factor 4930432K21Rik/C19ORF57/BRME1 modulates localizationof recombinase RAD51 and DMC1 to meiotic recombination sites

12:02-12:10

Y-05: Shunsuke Chuma (Institute for Protein Research, Osaka University)
Involvement of intracellular temperature in neuronal differentiation

12:10-12:18

Y-06: Rie Hasebe (Institute for Genetic Medicine, Hokkaido University)
Contralateral inflammation is developed by a sensory axis between joints in arheumatoid arthritis model

12:18-13:15

Lunch / Steering Committee Meeting of Institute Network for BiomedicalSciences (members only)

Session 2:

Cell Biology on Stress Response and Inflammation

Chair:

Miyuki Sato

13:15-13:40

S-04: Seiichi Oyadomari (Institute of Advanced Medical Sciences,Tokushima University)
Physiological and pathological role of the integrated stress response

13:40-14:05

S-05: Takashi Suda (Kanazawa University Cancer Research Institute)
Switches between apoptosis and pyroptosis

14:05-14:30

S-06: Fumiyo Ikeda (Medical Institute of Bioregulation, Kyushu University)
Regulation of inflammatory responses by the ubiquitin system

14:30-14:45

O-02: Satoru Torii (Medical Research Institute, Tokyo Medical and DentalUniversity)
Regulation of phosphorylation of Ulk1 in alternative autophagy

14:45-15:00

O-03: Takuma Kishimoto (Institute for Genetic Medicine, HokkaidoUniversity)
Activation and polarity formation of plasma membrane sterols

15:00-15:15

Break(Institute for Molecular and Cellular Regulation, Gunma University)

Short-talk Session for Young Researchers 2
Chair:

Tohru Ishitani (Research Institute for Microbial Diseases, Osaka University/ Institute for
Molecular and Cellular regulation, Gunma University)

15:15-15:23

Y-07: Yoshimasa Hamada (Institute of Advanced Medical Sciences,Tokushima University)

Regulation of Th17 cell differentiation by the integrated stress response
modulator
15:23-15:31

Y-08: Yukinari Haraoka (Research Institute for Microbial Diseases, OsakaUniversity)
Zebrafish imaging reveals additional TP53 mutation switches oncogeneinduced senescence from suppressor to driver in primary tumorigenesis

15:31-15:39

Y-09: Yuichi Hiraoka (Medical Research Institute, Tokyo Medical andDental University)
A mouse model of episodic ataxia type 6

15:39-16:47

Y-10: Takahiro Fukaishi (Institute for Molecular and Cellular Regulation,Gunma University)
Ppy-lineage β cells as a minor subpopulation from different origin

15:47-15:55

Y-11: Izumi Matsudaira (Institute of Development, Aging and Cancer,Tohoku University)
rs1360780 of the FKBP5 gene modulates the association between maternal
acceptance and brain structure in children and adolescents

15:55-16:03

Y-12: Atsuya Morita (Kanazawa University Cancer Research Institute)
The functional role of Tm4sf1 in colon cancer metastasis

16:03-16:11

Y-13: Daisuke Morita (Institute for Frontier Life and Medical Sciences,Kyoto University)
T-cell recognition of the lipopeptide-bound MHC class I complex: evidence
from the crystal structure

16:11-16:25

BreakSession 3:

Organogenesis, Reproduction, and Human Disease

Chair:

Yoshio Fujitani

16:25-16:50

S-07: Jun Shirakawa (Institute for Molecular and Cellular Regulation,Gunma University)
Heterogeneity of pancreatic islets

16:50-17:15

S-08: Akira Nakamura (Institute of Molecular Embryology and Genetics,Kumamoto University)
Assembly and phase transition of germ granules in the Drosophila ovary

17:15-17:30

O-04: Daiji Kiyozumi (Research Institute for Microbial Diseases, OsakaUniversity)
NELL2 is necessary for epididymal differentiation and male fertility

17:30-17:45

O-05: Yuki Yoshino (Institute of Development, Aging and Cancer, Tohoku
University)
Investigation and preclinical development on BRCA1 molecular function

17:45-18:00

O-06: Akio Kobayashi (Institute of Molecular Embryology and Genetics，Kumamoto University)
Regulation of cellular lineages during kidney development(Institute for Molecular and Cellular Regulation, Gunma University)

Friday, November 6, 2020
Keynote Lecture 2Chair:Tadahiro Kitamura (Institute for Molecular and Cellular Regulation, Gunma University)
Daisuke Kohno (Institute for Molecular and Cellular Regulation, Gunma University)

09:00-09:40

Joel K. Elmquist (The University of Texas Southwestern Medical Center,USA)
Using mouse genetics to unravel the CNS pathways regulating energybalance and glucose homeostasis

Session 4:

Immunology and Microbiology

Chair:

Tetsuro Izumi

09:40-10:05

S-09: Takayuki Kato (Institute for Protein Research, Osaka University)
Structural analysis of flagella motor by cryo-EM

10:05-10:30

S-10: Yuta Kochi (Medical Research Institute, Tokyo Medical and DentalUniversity)
Genetic dissection of complex diseases by splicing QTL analysis

10:30-10:45

O-07: Katsuhide Okunishi (Institute for Molecular and Cellular Regulation,Gunma University)
Exophilin-5 regulates IL-33-mediated Th2 responses

10:45-11:00

O-08: Shinya Tanaka (Medical Institute of Bioregulation, Kyushu
University)
Role of Ten-eleven translocation (Tet) in B cell self-tolerance

11:00-11:15

O-09: Yuki Furuse (Institute for Frontier Life and Medical Sciences, Kyoto
University)
Novel algorithm to identify beneficial genetic mutations in viral genome:
Ebola, Influenza, and SARS-CoV-2

11:15-11:30

Break(Institute for Molecular and Cellular regulation, Gunma University)

Keynote Lecture 3
Chair:

Takeshi Inagaki(Institute for Molecular and Cellular Regulation, Gunma University)

11:30-12:10

Yi-Ching Lee (Academia Sinica, Taiwan)
Studying from a rare disease to common diseases

12:10-13:10

Lunch

Session 5:

Innovative Life Science and Technology

Chair:Jun Shirakawa

13:10-13:25

O-10: Akio Kuroda (Institute of Advanced Medical Sciences, Tokushima
University)
Circulating cell free DNA and its clinical application

13:25-13:40

O-11: Qiuyi Wang (Institute for Protein Research, Osaka University)
Lithium ion adduction-based UPLC-MS/MS analysis of multi-class ketolic
steroid hormones containing a 3-hydroxyl group

13:40-13:55

O-12: Katsuya Sakai (Kanazawa University Cancer Research Institute)
Artificial Met agonists based on macrocyclic peptides and protein
engineering

13:55-14:20

S-11: Tomoji Mashimo (The Institute of Medical Science, The University ofTokyo)
CRISPR-Cas3: a new tool for genome editing and nucleic acid detection

14:20-14:45

S-12: Mototsugu Eiraku (Institute for Frontier Life and Medical Sciences,
Kyoto University)
Functional 3D tissue formation by in vitro manipulation and cell autonomy

14:50-14:55

Short Talk Awards Ceremony and Closing Remarks
Takeshi Inagaki (Institute for Molecular and Cellular Regulation, GunmaUniversity)(Institute for Molecular and Cellular Regulation, Gunma University)