North Campus

Campus MAP

Graduate School of Agriculture
Graduate School of Biostudies● Gene Biodynamics

Graduate School of BIOSTUDIES Kyoto University● Plant Molecular Biology

Main Campus● Biosignals and Response● Applied Molecular Microbiology

Institute for Integrated
Cell-Material Sciences (iCeMS)● Molecular Biology of Bioresponse● Plant Developmental Biology● Symbiotic and Coevolutionary Mechanisms● Developmental Neurobiology● Biochemical Cell Dynamics

Faculty of Agriculture Main Bldg

● Multidisciplinary Biology● Molecular and Cellular Biology of Totipotency

Faculty of Medicine Bldg G
South Campus Research Bldg

Hyakumanben(Graduate School of Biostudies)● Chromosome Transmission● Cell Cycle Regulation

Imadegawa St.

Hyakumanben● Cell Recognition and Pattern Formation

Kyodai Nogakubu-mae● Plasma Membrane and Nuclear Signaling

2023● Molecular and Cellular Biology● Immunobiology

St.

● Molecular Neurobiology

Higa
shioji● Science Communication● Graduate School of Biostudies(Office)Research Bldg. No.16● Signal Transduction

Science Frontier
Laboratory

Clock Tower● Functional Biology● Chromosome Function

Higashiyama higashi ichijo

and InheritanceFaculty of
Medicine Bldg A● Single-Molecule Cellu
Ky

Biology

Main Gate

Graduate School of Agriculture
Graduate School of Biostudies

a

ak

ir
sh

Higashi-Ichijo St.
St. Kyodai Seimon-maeaw

Medicine Campus
Faculty of Medicine Bldg F

Higashioji St.

Graduate School of
Pharmaceutical
Sciences Main Bldg.

● Genetics● Bioimaging and Cell Signaling

Graduate School of Biostudies,
Radiation Biology Center

South Campus Research Bldg (Bldg. G)
Science Frontier Laboratory● Genome Maintenance● Cancer Cell Biology● Chromatin Regulatory Network

KonoedoriKonoe St.

Marikoji St.

Pharmaceutical
ScienceCampus

Univ.
Hospital
East
Campus Kyodai

Institute for Life andMedical Sciences Bldg. No.2

● Brain Development and Regeneration

Hospital-mae

Faculty of Medicine Bldg F● Cell Division and Differentiation● Spatiotemporal Optical Control

Institute for Life andMedical Sciences Bldg. No.3

● RNA Viruses● Ultrastructural Virology

Kasugakita St.

Institute for Life andMedical Sciences Bldg. No.1

Graduate School of Biostudies,
Radiation Biology Center● Cellular and Molecular Biomechanics

AccessKeihan Limited Exp. 47min

Demachiyanagi Station

Osaka Umeda Station

Hankyu Limited Exp. 41min

Kyoto Kawaramachi
StationOsaka Station

JR Special Rapid Service 29min

Osaka International
Airport (Itami)

Airport Limousine Bus 60min

Kansai International
Airport

JR Airport Express “Haruka” 75min

Kyobashi Station

Kyoto
Station

20min Walk
Shijo Kawaramachi
StationKyoto city subway
For Kokusaikaikan
10min

Kyoto city bus(201, 31) 20min

Imadegawa Karasuma
Imadegawa
StationIn front of a Kyoto station

Kyoto city bus(201) 15min

Kyoto city bus(206) 30min

Contact

Graduate School of Biostudies Kyoto Univ. 【Inquiries concerning entrance examinationand "Global Frontier in Life Science”】
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501【Other Inquiries】

Student Affairs Section

Phone 075-753-9222
FAX
075-753-9229
Email kyomu@adm.lif.kyoto-u.ac.jp

General Affairs Section

Phone 075-753-9221 FAX 075-753-9247
Email soumu@adm.lif.kyoto-u.ac.jp

https://www.lif.kyoto-u.ac.jp/e/YoshidaCampusGraduate School of
BIOSTUDIES
Kyoto University

Graduate School of BIOSTUDIES,
Kyoto University

Challenge the mysteries of life!
Life science is the study that tries to understand

The Graduate School of Biostudies (GSB) was“the mechanism of life” . The mechanism of life canestablished in April 1999 as Japan’ s firstbe described as the rules of all life phenomena thatindependent graduate school for life sciences withhave been created over the 4.6 billion years since thethe aim of promoting world-leading life sciencebirth of the earth. The rules of life phenomena areresearches and fostering human resources beyond

unbelievably amazing. For instance, the genomic

the traditional framework of Science, Agriculture,

DNA in a cell is automatically and accurately

Pharmaceutical Sciences, and Medicine. Since then,duplicated in S phase, and then divides into two cells

for the past 24 years, leading researchers in various

on its own. When the sperm and egg are fertilized,

fields of life sciences have led their laboratories andthe fertilized egg begins cell division automatically,

achieved world-leading discoveries together with

causing differentiation, proliferation, migration, andstudents and staffs. In 2018, to further expand ourcell death precisely in a spatio-temporal manner andresearch scope and educational area, the Radiation

automatically creates the exact individual animal. It

Biology Center and the Research Center for Dynamic

is as if life is defying even the second law of

Living Systems were established. We also

thermodynamics, a major principle of the universe. In

established industry-university joint laboratories tofact, there is much we do not understand about how

promote social implementation of research results.

such a mysterious phenomenon occurs. Yes, there

In April 2023, we launched the Center for Living

are many life phenomena that we take for granted in

Systems Information Science (CeLiSIS), which is a

textbooks, but the details of their rules aredevelopmental reorganization of the Research Center

surprisingly unknown. Moreover, important life

for Dynamic Living Systems. CeLiSIS will promotephenomena that were previously unknown or

new researches that will lead data-driven life science,

overlooked are being discovered every year. Thus, life

as well as create a university-wide hub for fosteringscience is truly a treasure trove of research. On top of“two-way players” who can simultaneously acquire

that, a single big discovery in life science can change

big data through experimental science and performthe world instantly. In fact, we have just witnessed

information analysis, thereby playing a leading role in

one such example with the development of an mRNAthe digital transformation in life sciences.

vaccine against COVID-19, which was resulted fromthe latest basic research. Of course, life science is

In addition, the GSB offers various programs to

not only for curing human diseases. The discovery of

support students’ research and education globally,

new mechanisms of life opens up the possibility ofsuch as remote lectures with overseas universities, asignificant contributions to the welfare andprogram for sending students abroad, international

happiness of humankind, and even the earth itself,

student seminars organized by students, a program

through its application. Above all, the pleasure andto support international students, and a system for

excitement of discovering a new mechanism of life istransferring credits and promoting joint researches

incomparable to anything else. You may be moved bythrough inter-university agreements. We invite you tothe precision of life, bow down in awe at its mystery,join us and challenge the mysteries of life at the GSB.

and think of the evolutionary history of living

Beyond that, an exciting life far beyond yoursystems. If you publish it in a paper to the world, yourexpectation may await you!

discovery will be recorded forever as the knowledgeof humankind. I believe that life science is sointeresting and exciting that we do not even need toconsider about the major principles of the universe!

Dean, IGAKI, TatsushiG r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,MISSIONS of our GRADUATE SCHOOL

1

Provide education for
pursuing the new biostudies
at the world's top level
To meet the demands of the industry,college, research institutes andadministrative organizations, individuals are
educated in the life sciences and master thetechniques for the society needs.

2

Train individuals to apply the new life
sciences for the protection of the global
environment and for human welfare
Integrate the knowledge and technology inthe old fields of science, agriculture,
medicine and pharmacology, and nurtureindividuals who can contribute to thehuman society in the 21st century.

K y o t o

Admissions Policy of the Graduate School of Biostudies
Master’ s Program

Doctoral Program

As an advanced discipline that holds the key to the future of humankind, the life

As an advanced discipline that holds the key to the future of humankind, the life

sciences today are undergoing a major evolutionary change. In response to thissciences today are undergoing a major evolutionary change. In response to thisglobal trend, the Graduate School of Biostudies was founded in 1999 as Japan’ s

global trend, the Graduate

first independent graduate school focused on the life sciences with the

School of Biostudies was founded in 1999 as Japan’ s first independent

objective of building a world-class center for research and developing

graduate school focused on life sciences with the objective of building a

individuals who can lead the life sciences field into the next generation. Ourworld-class center for research and developing individuals who can lead the life

school has engineered a true fusion of cutting-edge areas in several existingsciences field into the next generation. Our school has engineered a true fusion

fields. By harnessing the common language of “cells, molecules, and genes”

of cutting-edge areas in several existing fields. By harnessing thethat together form the fundamental principles of life, we have developed an

3

integrated understanding of diverse life forms and the environments they help

Nurture individuals who canunderstand the various vital
phenomena of the living organisms
as a systemic function, andpursue these systemic functions

shape, and have launched innovative efforts in research and education that willproduce a new set of values for the future and dignity of life.
To meet the diverse expectations of society for advances in the life sciences,which are becoming increasingly sophisticated and complex, our school seeks
students from a broad spectrum of backgrounds who share these ideals of our

Nurture individuals who will be leaders in
the human society to pursue their activities
for the welfare and happiness of humans in
the 21st century, where humans will beliving in harmony with other living beings.

school, who possess basic academic skills and research aptitudes in the life
sciences, and who demonstrate a strong sense of ethics and responsibility intheir academic research. We especially welcome students who possess apioneering spirit to help propel the comprehensive and advanced branches ofthe life sciences, free from preconceptions, while fully appreciating the dignity

OPERATION POLICIES of our GRADUATE SCHOOL

of life. Accordingly, the Graduate School of Biostudies endeavors to cultivate
individuals with the following attributes:
1. Researchers ready to discover, or to shed fresh light on, fundamental
principles of life, who will pioneer new areas of the life sciences;Training of individuals with the mostadvanced knowledge of the life
sciences for the next generation

1

The graduate student studies a higher level oflife sciences beyond the structures of past life
science - related fields at each undergraduatelevel to understand the integrated life sciences.
The goal is to nurture a new type of individualwith creative and innovative abilities to cope withthe various unknown themes to be confronted
by human beings in the next generation.

Training to establish self
for society

2

In the Graduate School of Biostudies,
individuals are trained to make a healthy
and fair judgment based on the academic
background of the staff and their prospects
for the future; and, establish a new system
to evaluate the effects of education frommultiple aspects from the past.

2. Researchers and engineers committed to global environmental conservationand gains in human health, welfare, and well-being, who are ready to makesocial contributions through roles in public and private research institutions;
3. Educators and working professionals with a broad-based understanding of
the varied phenomena of life in general, who are ready to make social
contributions through roles in education, industry, the news media, andgovernment;
4. Researchers, educators, engineers, and working professionals who possess
strong communication skills that enable them to hold discussions withresearchers and others from Japan and around the world in life
science–related fields.

3
503

Activation and flexibility ofstaff in the human relations
Research is pursued by each staff
member independently to develop a newlife science based on active exchange
among the various laboratories in thegraduate school.

4common language of “cells, molecules, and genes” that together form thefundamental principles of life, we have developed an integrated understandingof diverse life forms and the environments they help shape, and have launchedinnovative efforts in research and education that will produce a new set ofvalues for the future and dignity of life.
To meet the diverse expectations of society for advances in the life sciences,which are becoming increasingly sophisticated and complex, our school seeks
students from a broad spectrum of
backgrounds who share these ideals of our school, who possess broad
academic knowledge and advanced expertise gained through their master’ s
education, who possess strong research ability,
and who demonstrate an even stronger sense of ethics and responsibility intheir academic research. We especially welcome students who possess apioneering spirit to help propel thecomprehensive and advanced branches of the life sciences, free frompreconceptions, while fully appreciating the dignity of life. Accordingly, theGraduate School of Biostudies endeavors tocultivate individuals with the following attributes:
1. Researchers ready to discover, or shed fresh light on, fundamental principles
of life, who will produce world-class research results in new areas of the life
sciences;
2. Researchers and advanced engineers committed to global environmental
conservation and gains in human health, welfare, and well-being, who are
ready to assume a leading role in public and private research institutions;
3. Educational leaders and high-level working professionals with a broad-based
understanding of the varied phenomena of life, who are ready to assume aleading role in education, industry, the news media, and government;

Use of current post-doctoral systemand evaluation of academic activities

The entrance exam will comprise achievement tests that include an assessmentof the applicant’ s ability to think logically in English, a skill that is required to

4. Researchers, educational leaders, advanced engineers, and high-level working

Full use should be made of the current system, toprovide the increasing necessary number of
instructors per student, for the intensive training
to become life scientists at an international level,
for true development of a new research field.

read and analyze an article published in an international journal; an assessment

professionals equipped with strong logical explanation and communicationof the applicant’ s general knowledge of molecular biology, cell biology,

skills, who can convey their ideas broadly to others in Japan and around thebiochemistry, and other life science fields; an assessment of the applicant’ sworld and assume a leading role in a variety of fields.

Promotion of gender equality
To promote gender equality, we draw up the action plan.
Also we enhance the research environment and support for child-rearing and caregiving.

Graduate School of BIOSTUDIES, Kyoto University

U n i v e r s i t yfundamental knowledge as required to pursue his or her intended field of study;

The entrance exam will comprise achievement tests that include an assessment

an assessment of the applicant’ s judgement, thinking ability, communicationof the applicant’ s ability to think logically in English, which is required forskills, initiative, and ethical perspective. Admissions decisions will be madeinternational communication; a presentation of the applicant’ s researchbased on the applicant’ s overall performance on these exams.

findings during their master’ s program or elsewhere; and an oral exam toassess the applicant’ s judgement, thinking ability, communication skills,
initiative, and ethical perspective. Admissions decisions will be made based on
the applicant’ s overall performance on these exams.

Graduate School of BIOSTUDIES, Kyoto University04

G r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,Curriculum Policies of the Graduate School of Biostudies

U n i v e r s i t y

Diploma Policy of the Graduate School of Biostudies

Master’ s Program

Doctoral Program

Master’ s Program

Doctoral Program

The Master’ s Program offers courses that appropriately combine lectures,

The Doctoral Program is comprised of lab-based research guidance and lectures

As an advanced discipline that holds the key to the future of humankind, the life

As an advanced discipline that holds the key to the future of humankind, the life

advanced studies, practical training, lab experiments, and seminars on

designed to cultivate greater breadth of scholarly knowledge and advanced

sciences are currently undergoing a major evolutionary change. The Graduate

sciences are currently undergoing a major evolutionary change. The Graduate

specialized subjects in order to achieve the objectives set forth in the Diploma

expertise in order to achieve the objectives set forth in the Diploma Policy.

School of Biostudies seeks to respond to this global change by building a

School of Biostudies seeks to respond to this global change by building a

Policy. Courses conducted in English are also offered for international students.

Courses conducted in English are also offered for international students. The

world-class center for research and by training human resources to lead the life

world-class center for research and training human resources to lead the life

The curriculum is specifically designed in accordance with the following

curriculum is specifically designed in accordance with the following principles.

sciences field into the next generation. Our school has engineered a true fusion

sciences field into the next generation. Our school has engineered a true fusion

1. The curriculum is organized and delivered to further develop broad scholarlyof cutting-edge areas in several existing fields and harnessed the commonof cutting-edge areas in several existing fields and harnessed the common

knowledge and advanced, specialized knowledge cultivated throughlanguages of cellular and molecular biology and genetics that together

languages of cellular and molecular biology and genetics that together

education in the Master’ s Program, and to enable students to acquire thearticulate the fundamental principles of life. Furthermore, it has developed anarticulate the fundamental principles of life. Furthermore, it has developed an

basic capabilities required of an independent researcher who can perform

integrated understanding of diverse life forms and the environments they help

integrated understanding of diverse life forms and the environments they help

a foundation of competence for occupations that demand advanced

well in an international setting. Moreover, research guidance is provided

shape, adding the perspective of mathematical science, and has launchedshape, adding the perspective of mathematical science, and has launchedexpertise, based on the basic academic capabilities and specializations

through special seminars and special workshops in individual research labs

innovative efforts in research and education that will define a new set of values

innovative efforts in research and education that will define a new set of values

developed through education in the undergraduate program, as well as toto cultivate advanced competence in research planning and implementation,

for the future and dignity of life.

for the future and dignity of life.

enable the pursuit of cross-disciplinary study unencumbered by existinga capacity to explain research findings theoretically, communication skills,

To meet the diverse expectations of society for advances in the life sciences,

To meet the diverse expectations of society for advances in the life sciences,fields of specialization, which allows students to apply broad visions to put

and firm ethical integrity and a strong sense of responsibility in academic

which are becoming increasingly sophisticated and complex, the Graduate

which are becoming increasingly sophisticated and complex, the Graduate

their own research into perspective and build systems of knowledge.

research. Learning outcomes in each course are evaluated through written

School of Biostudies confers the degree of Master of Life sciences on students

School of Biostudies confers the degree of Doctor of Philosophy in Life sciences

Moreover, the curriculum includes practical training, lab experiments,

examinations, report examinations, and the outcomes of workshops, lab

who maintain enrollment for the requisite period, complete curricular courses,

on students who maintain enrollment for the requisite period, complete

experiments, and practical training.

earn the prescribed number or more of credits in accordance with thecurricular courses, earn the prescribed number or more of credits in accordanceCurriculum Policy, and pass a review and examination of a master’ s thesis

with the Curriculum Policy, and pass a review and examination of a doctoral
dissertation prepared after undergoing the required research guidance. A further

principles.
1. The curriculum is organized and delivered to cultivate broad scholarly
knowledge spanning all domains of the life sciences, research capability instudents’ field of specialization, and specialized knowledge that will provide

workshops, and tutorials held in individual research labs that are designed tocultivate competence in research implementation, a capacity to explain

2. Special emphasis is placed on students’ proactive pursuit of a research topic
that contributes to an academic or practical area of the life sciences,

prepared after undergoing the required research guidance. A further prerequisite

integrity and a sense of responsibility in academic research. Learning

mediated by research guidance and practical education, and leads to afor degree conferment is the attainment of the following:

prerequisite for degree conferment is the attainment of the following:outcomes in each course are evaluated through written examinations, reportdoctoral dissertation that contributes to the generation of new knowledge.

1. Broader-based scholarly knowledge; research capability in their field of

1. Broad-based scholarly knowledge and advanced, specialized knowledge to

examinations, and the outcomes of workshops, lab experiments, andThis dissertation is assessed by a panel of three examiners and one or more

specialization; and advanced, specialized knowledge required forresearch findings theoretically, communication skills, and firm ethicalpractical training.
2. Emphasis is placed on students’ proactive pursuit of a research theme thatexpert examiner in accordance with the Diploma Policy.
The curriculum created on the basis of the above policies is presented incontributes academically or practically to the life sciences, mediated bycurriculum maps, and the details of each individual course are clearly stated inresearch guidance and practical education, and leads to a master’ s thesis

the syllabus.

with theoretical value. This thesis is assessed by a panel of three examiners
in accordance with the Diploma Policy.
The curriculum created on the basis of the above policies is presented in

occupations that demand advanced expertise
2. Firm ethical integrity and a sense of responsibility in academic research in
the life sciences field
3. Appropriate capabilities in research implementation in order to set topics and●Experimental Course and Seminar(20 credits : compulsory)

Requirements forcompleting the Doctoral program●Advanced Experiments(8 credits : compulsory)●Common Compulsory Subject (1 credit)●Common Compulsory Subject (1 credit)●Common Elective Subjects (at least 9 credits)●Common Elective Subjects (at least 1 credit)

For graduation, the student must have enrolled

For graduation, the student must have enrolled forfor at least two years and have completed at

at least three years and have completed at least 10

least 30 credits. It is also required to pass thecredits. It is also required to pass the probation

probation and an examination upon completionand the examination (thesis defense) uponof the Master’ s thesis written under thecompletion of a Doctoral thesis written under thesupervision of faculty.

supervision of faculty.

Graduate School of BIOSTUDIES, Kyoto University

research in the life sciences field
3. Advanced capabilities in research planning and execution in order to set
unique topics and themes based on scholarly knowledge, techniques, andskills in the life sciences field, and to achieve solutions and development

and fields related thereto, and to deepen mutual understanding

Requirement forcompleting the Master’ s program

occupations
2. Firm ethical integrity and a strong sense of responsibility in academic

sciences field, and to achieve solutions and development thereof

promote one’ s research findings to researchers in one’ s own specialization

the syllabus.

engage as independent researchers or lead careers in advanced professional

themes based on scholarly knowledge, techniques, and skills in the life

4. Appropriate skills in theoretical explanation and communication required tocurriculum maps, and the details of each individual course are clearly stated in05

K y o t o

5. A master’ s thesis, presented with theoretical rigor and clarity, withappropriate setting of research goals, planning, and execution ofexperimental work related thereto and discussion in regard to the findings
thereof

thereof through planning and implementation of joint research with otherresearch institutions as necessary
4. Advanced skills in theoretical explanation and communication required topromote one’ s research findings to researchers in one’ s own specializationand fields related thereto, and to deepen mutual understanding
5. Doctoral dissertation that includes research findings demonstrating new
discoveries or concepts that contribute academically or practically to the life
sciences
Candidates considered to have made outstanding progress in their studies andresearch may be eligible for completion of the doctoral program in a reduced
period of enrollment.

Graduate School of BIOSTUDIES, Kyoto University

06

G r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,K y o t o

U n i v e r s i t y

Composition of Departments

Research Laboratories in the Graduate School of Biostudies
Division of Integrated Life Science

Division of Systemic Life Science

In this division, education and research are focused on the elucidation of basic mechanisms regulating the chromosome transmission,

In this division, education and research are focused on the elucidation of the fundamentals of molecular andsystemic biology, cell biology and immunology. Experimental approaches are taken with viruses,
microorganisms, cultured cells and animals. We pursue education and research to elucidate the molecular
aspects of Systemic Life Science.

chromosome replication, RNA architecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development,
developmental plasticity, bioconversion, and environmental adaptation. Experimental approaches are taken with microorganisms,
plants, and animals. We pursue education and research to elucidate the molecular aspects of Integrative Life Science.

Dept. of Gene Mechanisms

Chromosome Transmission/Gene Biodynamics/Cell Cycle Regulation

9

Major interest is the molecular mechanism of higher order phenomena (cell proliferation, morphogenesis,
canceration, aging, etc.) and the cellular function (cell cycle, chromosome replication, segregation, maintenanceand repair, etc.) in unicellular and multicellular organisms.

Dept. of Cell and Developmental Biology

Cell Recognition and Pattern Formation/Signal Transduction

Plant Molecular Biology/Molecular and Cellular Biology of Totipotency

11

13

The department pursues the basic research and application of molecular and cellular principles related toplant growth and development. We take approaches by cell biology, chemical biology, molecular and cellularbiology, molecular genetics, and genomics.

Dept. of Applied Molecular Biology

Biosignals and Response/Applied Molecular Microbiology/
Molecular Biology of Bioresponse

Plant Developmental Biology/
Plasma Membrane and Nuclear Signaling

15

Developmental Neurobiology/Biochemical Cell Dynamics/
Multidisciplinary Biology

18

19

Molecular and Cellular Immunology/Ultrastructural Virology

21

We study on mammalian development, differentiation, aging and viral immunity. We utilize molecular biology anddevelopmental engineering as tools of analyses to elucidate mechanisms at molecular, cellular and animal levels.

Dept. of Human-Residential Bifidobacteria (HRB) Research (Industry-Academia Collaboration Course)

Symbiotic and Coevolutionary Mechanisms

Attached
Research Centers
07

Radiation System Biology/Mutagenesis/Late Effects Studies/Genome Repair Dynamics/
Chromosome Function and Inheritance/Stress Response

Strategic Education Program/Computational and Systems Biology/
Computational Genomics/Advanced Big Data Analysis

Our center consolidates and systematizes informatics-based educational and research resources in life sciencethroughout Kyoto University, and develops new programs in order to generate expert "two-way" researchers who leaddata-driven life science.

Graduate School of BIOSTUDIES, Kyoto University

26

Cancer, autoimmune diseases, and life-style related diseases can be caused by genetic abnormalities andaberrant response mechanisms. We aim to reveal dysfunctional biological mechanisms of cell proliferation,
cancer, and immunological, genetic diseases.
Functional Biology

28

Using animal models of human diseases, such as neurodegenerations, cancers, and obesity-relateddiseases, and using metabolite imaging techniques, we aim to elucidate molecular bases of such diseases
and develop new strategies to cure or prevent them.
Science Communication/Chromosome Function and Inheritance29

The Department of Biology Education and Heredity is composed of the Laboratory of Science Communication,and the Laboratory of Chromosome Function and Inheritance. The Laboratory of Chromosome Function andInheritance studies the mechanisms of meiosis using cell biological and genetic approaches. The department
as a whole focuses on training internationally-minded scientists, developing English-based science educationand communication at the highest levels.

Dept. of Systems Biology

Bioimaging and Cell Signaling/Theoretical Biology/Brain Development and Regeneration

31

By the use of cutting-edge technologies of microscopy, optogenetics, and chemical biology, we will study the
information that living organism perceive. Based on the accumulated information, mathematical models arebuilt to understand systematically the mechanism of information processing of living organisms. We will
also analyze the molecular mechanisms that regulate quiescence and activation of adult neural stem cells.

Dept. of Genome Biology

Genome Maintenance/Cancer Cell Biology/Chromatin Regulatory Network

34

Genome and epigenome information are maintained by an intricate molecular system acting against exogenousand endogenous perturbations. We aim to study defects in these mechanisms that result in human disorders.
41

Our center is trying to elucidate basic mechanisms behind biological responses to irradiation as well as chromosomal damages,
and thereby pursue fundamental basis for evaluation of radiation exposure risks and for development of innovative cancer radiation
therapy. To achieve the goals, our center promotes collaborations in the intranational and international research communities.

Center for Living Systems Information Science(CeLiSIS)

24

22

The mission of this department is to elucidate the mechanisms underlying symbiosis between
bifidobacteria and their human host, and to understand the molecular basis of the health-promoting effects ofprobiotic Bifidobacterium strains.

Radiation Biology Center

Molecular and Cellular Biology/Immunobiology/
Molecular Cell Biology and Development

Molecular Neurobiology/Genetics

Dept. of Biology Education and Heredity

The development, function, and maintenance of tissues and organs are regulated by a coordinated interplay ofcell-intrinsic programs and intercellular signals. We seek their mechanisms at cellular, organellar andmolecular mechanisms using various model systems, including the brain and immune systems.

Dept. of Molecular and Cellular Biology

23

The objectives of our studies are to clarify the mechanisms that regulate hierarchical structures composing
cells, tissues, organs, at the molecular, cellular, and individual levels, especially about cell growth,differentiation, cell death, cell-cell interactions, and histogenesis.

Dept. of Functional Biology

We aim at understanding fundamental systems underlying environmental responses by organisms throughstructural-functional study of information molecules involved in environmental responses and study ofregulatory mechanisms of development in response to environmental signals.

Dept. of Molecular and Developmental Biology

Dept. of Animal Development and Physiology

Dept. of Signal Transductions

Signal response mechanisms have evolved in organisms through adaptations to fluctuations or changes in the naturalenvironment. These mechanisms are being elucidated using various model organisms at different levels (individual, organ,
tissue, cell, molecule and gene), and directing this knowledge toward applications with benefits to human welfare is a priority.

Dept. of Responses to Environmental Signals and Stresses

Single-Molecule Cell Biology

We will challenge direct viewing of biomolecular dynamics using single-molecule imaging and multi-target
super-resolution microscopy IRIS. By elucidating the molecular basis of morphogenesis and the action ofdrugs, we will pursue principles in biology and seeds for drug development.

We are studying signal transduction mechanisms that control organogenesis and animal growth in response to nutrition
and growth factors. We are also dissecting operating principles of neuronal circuits that evoke behaviors to sensory stimuli.

Dept. of Plant Gene and Totipotency

Dept. of Molecular and System Biology

Dept. of Mammalian Regulatory Network

RNA Viruses/Cell Division and Differentiation/
Cellular and Molecular Biomechanics

37

Laboratories consisting of this Department study multi-dimensional networks of life signals that contributeto the integrity of higher organisms. Studies also include those utilizing viruses, animal models, andbiomaterials, serving to establish basic principles in life science.
43

Dept. of Advanced Imaging (Industry-Academia Collaboration Course)

Spatiotemporal Optical Control

40

We will understand the principle of biological functions by measuring and manipulating dynamics of genes andmolecules multidimensionally with cutting-edge imaging, optical control technologies, and optical probes.

Graduate School of BIOSTUDIES, Kyoto University

08

Division of Integrated Life Science ｜ Department of Gene Mechanisms

Laboratory of
Chromosome
Transmission

Division of Integrated Life Science ｜ Department of Gene Mechanisms

Professor

Assoc. Prof.

UEMURA, Tadashi（Concurrent post）

NAKASEKO, Yukinobu

Main theme

Main theme

We are focusing on analyzing the genes
involved in regulation of chromosome
function. Especially, the genes essential for
mitosis have been studied. Fission yeast
Schizosaccharomyces pombe is used as amodel system. This yeast has all basic
features essential for eukaryotic cell
division. Many genes have been identified
which regulate the cell cycle of this yeast.
Also, their functions as well as their primarystructure have been shown to be conserved
among all eukaryotic cells. We are trying tocharacterize these genes and their functions
by genetical approach.

Stress is generally considered to be
non-adaptive. However, low-dose stresscan act in an adaptive role by fostering cell
resistance to prospective lethal stresses.
This process is termed acquired tolerance(or hormesis) and its molecularmechanisms remain largely unknown. We
are trying to understand how acquired
tolerance is induced molecularly. Arguably,
cancer cells in vivo acquire stressresistance through experiencing
ever-lasting environmental changes. As
such, inhibiting the acquired tolerance incancer cells may lead to fragility of cancers
to various stresses, including iatrogenic
ones.

Elucidation of whole functional network ofthese genes is one of a goal in our research.

• Functional roles of acquired tolerance invarious physiological and pathologicalconditions.

Laboratory ofGene
Biodynamics• Development of therapeutic strategies forcancer by elucidating the mechanisms ofcellular senescence.

Specially Assigned
Assoc. Prof.

MIYOSHI, Tomoichiro

Assist. Prof.

NAKAOKA, Hidenori

In general, cells exposed to lethal stress undergo cell
death (A). However, cells preconditioned with mild stresscan become resistant to subsequent lethal stresses (B).
This process is called acquired tolerance or hormesis: anadaptive behavior that is crucial for survival in anever-changing environment. In vivo, cancer cells canexperience environmental changes such as hypoxia andiatrogenic stress. This is in contrast to normal cells thatlive in a stable niche given by the tissue. It is possiblethat cancer cells are pre-conditioned by theenvironmental changes to prepare for the prospective
lethal stress. Therefore, inhibition of this acquired
tolerance may make cancer cells sensitive to anti-cancer
therapeutics.

Assoc. Prof.

SHIRAISHI, Hideaki

We are interested in the mechanism of growth,development and evolution of photosynthetic
microorganisms and currently focusing on the
study of the edible cyanobacterium Arthrospira(Spirulina) platensis. A. platensis is afilamentous alkalophilic cyanobacterium thathas been traditionally consumed as food bypeople living along the shores of alkaline lakes
in several regions in the world. Because it canbe cultured under alkaline conditions where
growth of other microalgae is suppressed, it
can be produced in mass cultures outdoors as
an almost single algal strain. Because of its
easiness of mass culture, it is commercially
produced in many subtropical areas in the

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

http://kuchem.kyoto-u.ac.jp/seika/

world and consumed worldwide as food, foodadditives, and feed for animals and fishes. We
are currently focusing on developing tools formolecular genetic studies of thiscyanobacterium.

Filamentous cyanobacterium Arthrospira platensis
and the aggregated expolysaccharides produced bythemInter-organ signaling regulates nutrient-dependent
hyperarborization of somatosensory neurons.
This study was published in eLife on Jan 17, 2023.
Nutrition in early life has profound effects on anorganism, altering processes such asorganogenesis. However, little is known about how
specific nutrients affect neuronal development.
Yasutetsu Kanaoka, Tadashi Uemura, and Yukako
Hattori (Laboratory of Cell Recognition and Pattern
Formation) addressed this question using one of thesomatosensory neurons in the Drosophila larva. They
revealed that a combined deficiency of vitamins,
metal ions, and cholesterol increases the productionof a signaling molecule, Wingless, in a closely
located tissue, body wall muscle. A larger amount of
Wingless is released from muscles and promotes thedendrite branching of the neuron. Additionally, it issuggested that this low-nutrient-dependent neuronal
growth helps larvae keep searching for high-nutrient
foods in the presence of noxious environmental
threats. Together, this study illustrates how theavailability of specific nutrients affects neuronaldevelopment through inter-organ signaling.

TOPICS

Main theme

09

Laboratory of
Cell Cycle
Regulation

The muscle-neuron signaling regulates dendrite branching in
response to nutrient deficiency

For further information, please refer to the URL below.

https://elifesciences.org/articles/79461

Graduate School of BIOSTUDIES, Kyoto University

10Division of Integrated Life Science ｜ Department of Cell and Developmental Biology

Division of Integrated Life Science ｜ Department of Cell and Developmental Biology

Laboratory of
Cell Recognition and
Pattern Formation

Senior Lecturer

KUSAKABE, Morioh

Main theme
Professor

UEMURA, Tadashi
Senior Lecturer

USUI, Tadao

Main theme
We are interested in:
1. Contributions of nutrients andassociated microbes to animal growth
and aging

HATTORI, Yukako  

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Multiciliated cell differentiation in asalt-and-pepper pattern

http://www.signal.lif.kyoto-u.ac.jp/ 

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Lab URL

11

Graduate School of BIOSTUDIES, Kyoto University

Lab URL

Auxin signaling is essential for organogenesis but not for cell survival in theliverwort Marchantia polymorpha ―No auxin signaling, no 3-D morphogenesis―         子孫"Microinjection into Xenopus laevis
embryos at the cleavage stage

          

MIYATA, Yoshihikoᄝ       

http://www.cellpattern.lif.kyoto-u.ac.jp/

This study was published in The Plant Cell on 6th February 2023.
The three-dimensional mode of development, in whichorgans are formed from stem cells at the apex of theplant body, is thought to have been acquired in thecommon ancestor of land plants and is also found in
bryophytes. Auxin, which plays an important role in
the regulation of cell division, is transmitted via an
auxin receptor called TIR1/AFB, which causeschanges in gene expression. In angiosperms,
TIR1/AFB multiple mutants are lethal early indevelopment, and thus auxin signaling was thought tobe important for development, but it was unclear
whether the lethality was the results of developmental
arrest or requirement for survival itself. Professor
Takayuki Kohchi and his colleagues used Marchantia
polymorpha, which has low genetic redundancy andonly one auxin receptor gene, to completely disable

auxin signaling, resulting in the formation of cellmasses with no distinct organs at all. This resultclearly proves that auxin signaling plays an essential
role in 3D development, but also reveals theunexpected fact that auxin signaling is not essential
for the survival and proliferation of the bryophyte
cells.

TOPICS    



 

Assist. Prof.

We are interested in identifying andelucidating molecular mechanisms that
regulate cell proliferation, cell differentiationand developmental processes. The current
topics include 1) regulatory mechanisms andfunctions of the MAP kinase cascade
pathways, 2) identification of novel signaltransduction mechanisms, 3) roles of protein
kinases in cell regulation, 4) signalingmechanisms in developmental processes.

    

Assist. Prof.

3. Reproductive manipulation ( “malekilling” ) caused by insect symbionts  

       

2. Neuronal circuits that evoke selective
behaviors in response to sensory
stimuliLaboratory of
SignalTransduction

For further information, please refer to the URL below.

https://doi.org/10.1093/plcell/koac367

Graduate School of BIOSTUDIES, Kyoto University

12Division of Integrated Life Science ｜ Department of Plant Gene and Totipotency

Division of Integrated Life Science ｜ Department of Plant Gene and Totipotency

Laboratory of
Molecular and Cellular
Biology ofTotipotency

Laboratory of
Plant Molecular
Biology

Professor

Professor

KOHCHl, Takayuki
Assoc.Prof.

YASUI, Yukiko

Assist. Prof.

NAKANO, Takeshi
Main theme
Research in this laboratory focuses on
the adaptive regulation of growth anddevelopment to environmental
conditions and its evolution by using
model photosynthetic organisms.
Especially with the liverwort Marchantia
polymorpha, which is a basal land plant
ideal for comparative evolutionary

studies and amenable to molecular
genetic manipulation, we aim toelucidate principles and ancestral
molecular mechanisms ofphotomorphogenesis, growth phasetransition, phytohormone signaling,meristem function, sex determination,and sex differentiation in land plants.

YOSHITAKE, Yoshihiro

Graduate School of BIOSTUDIES, Kyoto University

Major research topics are:Plant growth has been administrated bycooperative regulations between plant
cell differentiation/division/elongationand photosynthesis. Based on thesescientific aspects, our laboratory istrying to reveal the plant growthmechanisms by ‘chemical biology’ and‘molecular and cellular biology’ .

(1) Growth regulation by plant hormone
signaling

Assoc.Prof.

http://www.plantmb.lif.kyoto-u.ac.jp//

MIYAKAWA,Takuya(2) Chloroplast regulation byprassinosteroid(3) Chemical functions to regulate plant
growth and differentiation(4) Plant biomass production regulated
by chemicals and genes(5) Protein functions to regulate plant
growth mechanism by structure
biologyLab URL

13

Main theme

https://plantchembio.lif.kyoto-u.ac.jp/

Assist. Prof.

YAMAGAMI, Ayumi

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

14

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Laboratory of
Biosignals andResponse

Assoc. Prof.

YAMANO, Takashi

Main theme
Professor

NAGAO, Masaya
Assoc. Prof.

KAMBE, Taiho

Assist. Prof.

Main theme
Bio-prospecting, a research strategy
searching for compounds that possess
beneficial activity for health from natural
sources, is one of the projects in thislaboratory. Especially, compounds thatare useful for treatment oflifestyle-related diseases and cancer are
the main targets of our bio-prospecting.

We are also studying how organisms
perceive environmental signals andtransduce these signals into changes ingene expression, focusing mainly on themolecular and cellular basis of zincmetabolism (such as uptake, storage,
delivery, and maintenance of metal
concentration in cells) in mammal.

NISHINO, Katsutoshi

Using the model green alga
Chlamydomonas reinhardtii, also known
as "green yeast," we will elucidate survival
strategies of microalgae in response tovarious environmental stresses at the
genomic and molecular levels andexpand our research into applications
such as modification of photosynthesis,
CO2 reduction, bioenergy, and valuable
material production.

・protein localization changes in response
to environmental stimuli and their
physiological significanceLaboratory ofApplied
Molecular
Microbiology
Assist. Prof.

TSUJI, Yoshinori

Current projects
Molecular mechanisms of・photosynthetic regulatory network bysensing environmental signals
・photosynthetic CO2-concentrating
mechanism
・formation, disappearance, andinheritance of phase-separatedorganelles

・signal transduction, energy storage, andinduction of sexual reproduction during
nutrient starvation

http://www.molecule.lif.kyoto-u.ac.jp/

Lab URL

Stimulation of lipid accumulation by plant extracts

The findings were published in The ISME Journal.
Bifidobacteria are among the first colonizers of theinfant gut, and human milk oligosaccharides (HMOs)
in breastmilk are instrumental for the formation of abifidobacteria-rich microbiota. However, little is
known about the assembly of bifidobacterial
communities. Prof. Katayama’ s group showed that
arrival order and sugar consumption phenotypes
significantly affected community formation.
Bifidobacterium breve, a species with limited
HMO-utilization ability, benefits from priority effects
to dominate the communities, which wasdemonstrated by in vitro co-cultivation studies and in
silico data mining analysis of infant fecal
metagenome. The study highlights the importance ofinitial community assembly and its implications for
Lab URL

15

Graduate School of BIOSTUDIES, Kyoto University

http://www.seitaijoho.lif.kyoto-u.ac.jp/

the maturation trajectory of the infant gut
microbiota. As several HMOs have been recently
commercialized to fortify formula, the results arealso important for conducting evidence-based
clinical intervention testing probiotic efficacy.

TOPICS

Priority effects shape the structure of Bifidobacterium communities
in infant gut microbiome.

B. breve dominates bifidobacterial communities in infant
gut microbiomes when introduced into the environment
during the early stages of assembly.

For further information, please refer to the URL below.

https://www.lif.kyoto-u.ac.jp/j/research/research_results/cat10/2022-07-27-02/
https://www.nature.com/articles/s41396-022-01270-3

Graduate School of BIOSTUDIES, Kyoto University

16

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Division of Integrated Life Science ｜ Department of Responses to Environmental Signals and Stresses

Laboratory of
Molecular Biology ofBioresponse

Laboratory of
Plant Developmental
Biology

Professor

Professor

KATAYAMA, Takane
Assoc. Prof.

KATOH, Toshihiko

ARAKI, Takashi
Main theme
We are conducting research focusing on
the symbiosis and co-evolution between
gut microbes and the host. In particular,
we are trying to understand themolecular basis of how gut microbes
proliferate and persist in the host gut by
assimilating milk oligosaccharides andmucin O-glycans produced by the host.

Lab URL

17

Graduate School of BIOSTUDIES, Kyoto University

・Symbiosis between bifidobacteria andinfants mediated through breastmilk
・Carbohydrate assimilation mechanism
in gut microbes
・Aromatic amino acid metabolism in gut
microbes
・Development of an apical aerobic
co-cultivation device

http://www.bunshioutou.lif.kyoto-u.ac.jp/

Main theme
We are interested in molecularmechanisms underlying plant's
responses to environment. Plants have
evolved plastic developmental programswith both genetic and epigenetic basis toadapt their sessile mode of life tochanging environment. Using anangiosperm, Arabidopsis thaliana and aliverwort, Marchantia polymorpha asmodel systems, we have been

investigating (1) regulation of growthphase transition (especially reproductive
transition) in response to environmental
signals, (2) mechanism of day-length
perception by photoreceptors andcircadian clock, (3) long-distancesystemic signaling (e.g. florigen) in thecontrol of development, (4) sexual
reproduction processes (especially,
germline specification andgametogenesis), and (5) origin andevolution of regulatory systems forplastic development.

http://www.plantdevbio.lif.kyoto-u.ac.jp/

Assoc. Prof.

YAMAOKA, Shohei

Assist. Prof.

INOUE, Keisuke

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

18

Division of Integrated Life Science ｜ Department of Responses to Environmental Signals and Stresses

Laboratory of
PlasmaMembrane andNuclear Signaling
Assist. Prof.

KUMETA, Masahiro

Division of Integrated Life Science ｜ Department of Molecular and Developmental Biology (Cooperation Course)

Assoc. Prof.

Professor

YOSHIMURA, Shigehiro

SUZUKI, Jun
AFFILIATION：
Institute for Advanced Study

Main theme
Our laboratory studies dynamic properties ofcellular proteins and membrane in cellularenvironments by using a variety oftechniques in biochemistry, cellular biology
and biophysical approaches. We are alsointerested in how those dynamics of cellulararchitectures are related to diseases.
Specific research topics include:(1) How post-translation modification suchas phosphorylation regulates liquid-liquid
phase separation(2) How protein assembly near the plasma
membrane induces phase separation andmembrane deformation(3) How intracellular membrane-lessorganelles play roles in anti-viral functionof host factors(4) Nucleolus as a multi-component
liquid-liquid phase separation system

Lab URL

Main theme
In principle, we identify specific genes
regulating the biological phenomenon with ourinterests. The main approaches are as follows:
Expression cloning using cDNA library,functional screening using sgRNA library in a
CRISPR/Cas9 system, biochemical approach incombination with mass spectrometry. By
establishing the robust experimental systems,
we try to reveal the secrets of biologicalphenomenon. Currently, we are interested in the
biological phenomenon called phospholipid
scrambling that regulates blood coagulation,
engulfment of dead cells, cell fusion, cancer
progression, stress response, regulation ofbrain/bone/muscle functions and so on. In spiteof its importance in various biological systems,
much is unknown about how phospholipid

http://www.chrom.lif.kyoto-u.ac.jp/

scrambling is regulated. We are going to
uncover the mechanisms.

Research Topic・Identification of novel scramblases onplasma membranes
・Identification of novel scramblases on
intracellular membranes
・Identification of regulators or subunits inscramblases
・Understanding physiological roles ofscramblases
・Understanding how diseases occur by
scramblase deficiency
・Understanding mechanisms of removal ofunwanted cells
・Developing in vivo screening systems

http://www.suzuki.icems.kyoto-u.ac.jp/en/

Lab URL

Division of Integrated Life Science ｜ Department of Molecular and Developmental Biology (Cooperation Course)

Laboratory ofDevelopmental
Neurobiology

Professor

TANIGUCHI, Yuichi

Professor
AFFILIATION：
Institute for Advanced Study

During brain development, neurons
directionally migrate from the birthplace totheir destination within the cortex, and thenarborize well-patterned dendrites and axons tocontact with their specific synaptic
counterparts. Failures in these processes leadto neurodevelopmental and neuropsychiatry
diseases. The major goal of our research is toclarity the mechanisms that govern theformation and maintenance of the mammalianbrain.

Laboratory ofMultidisciplinary
Biology

AFFILIATION：
Institute for Advanced StudyKENGAKU, Mineko

Main theme

Laboratory ofBiochemical
Cell Dynamics

Main theme(cell migration, process arborization,organelle transport, etc).
Elucidating the mechanism of external
stimuli-dependent neuronal differentiationand circuit organization.
Developing live imaging techniques forreal-time observation of molecular andcellular dynamics of brain development.

Research Topic

We aim to understand the working principle ofcomplex biological systems (e.g. the cell andgenome) constituted with a wide variety ofmolecules. Based on knowledge of multiple
academic fields including biology, physics,
chemistry, computer science, engineering andinformatics, we challenge development of new
innovative technologies and creation of new life
science fields.

・Elucidating the working principles of the
genome based on molecular or atomic
structures
・Understanding the constitutional principlesof single cells
・New principles and methods in diseasediagnosis and treatment

Research Topics
Live imaging and molecular analyses ofdynamics and kinetics of neuronal motilities

Lab URL

19

Graduate School of BIOSTUDIES, Kyoto University

http://www.kengaku.icems.kyoto-u.ac.jp

Nucleosome-resolved 3D
genome structure

Single molecule fluorescence microscope

https://taniguchi.icems.kyoto-u.ac.jp/en

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

20Division of Integrated Life Science ｜ Department of Molecular and Cellular Biology (Cooperation Course)

Laboratory of
Molecular andCellular
Immunology

Laboratory ofSymbiotic andCoevolutionary
Mechanisms

Professor

NODA, Takeshi（Concurrent post）

AFFILIATION：Institute for Life and Medical Sciences

Main theme
Virus infections, such as influenza A epidemic,
Ebola hemorrhagic fever, Middle East
respiratory syndrom, Zika virus infection areimportant diseases and outbreaks of newly
emerging viruses are serious problems formodern society. Higher animals, including
humans, are genetically equipped withmechanisms, collectively known as innate
immunity, to counteract viral infections. During
the course of replication, many viruses
generate double-stranded (ds)RNA, which isvirtually absent in normal cells and likely
serves as a "foreign molecule" in cells. An RNA
helicase, RIG-I, functions as a sensor for viraldsRNA. RIG-I is composed of three domains : a
Caspase recruitment domain (CARD), a

Laboratory of
Ultrastructural
Virology

Division of Integrated Life Science ｜ Department of Human-Residential Bifidobacteria (HRB) Research (Industry-Academia Collaboration Course)

DExD/H helicase domain, and a C-terminal
domain (CTD)(Figure). CTD senses viral dsRNA
produced in the cytoplasm, leading to a
conformational change. This conformationalchange releases CARD, which signals to
downstream, resulting in the activation ofgenes including those for type I interferon andother cytokines. The purpose of our project is
to clarify the molecular mechanism underlying
the antiviral innate immunity regulated by
RIG-I, and to develop new diagnostic andtherapeutic means for viral infections.

Department Overview

The department of Human-Residential Bifidobacteria (HRB) Research was established in October 2020 as
an industry-academia research collaboration between Morinaga Milk Co. Ltd., and the Graduate School of
Biostudies, Kyoto University. The mission of this department is to elucidate the mechanisms underlying
symbiosis between bifidobacteria and their human host, and to understand the molecular basis of thehealth-promoting effects of probiotic Bifidobacterium strains.

Research Theme

Probiotics are defined as “live microorganisms
that, when administered in adequate amounts,
confer a health benefit on the host," andbifidobacteria and lactobacilli are most commonlyused as probiotics in food and medicine globally.
Research suggests that bifidobacteria haveco-evolved with hominids for over 15 million years,
and we have collectively named the species thatare characteristic of the human intestinal tract as“Human-Residential Bifidobacteria (HRB)".
Accumulating evidence shows that HRB plays an
extremely important role in human health.
However, the mechanisms behind the probiotic
effect of bifidobacteria remain unclear, because
probiotics research has historically focused on

the human (host) side (e.g., functional evaluation
through clinical trials) and research from thebacterial side is limited. To address this researchgap, our department will promote research fromthe probiotic side. Specifically, we will elucidate
the molecular mechanisms underlying symbiosis
and coevolution between HRB and humans.

Project-Specific
Assoc. Prof.

SAKANAKA, Mikiyasu

Visiting Professor

XIAO, Jin-zhong

Research Topics

・Elucidation of the symbiotic and co-evolutionary
mechanisms between bifidobacteria, gut
bacteria, and humans.
・Understanding the molecular basis ofhealth-promoting effects of probiotics anddevelopment of technologies for social
implementation.

Visiting Assoc. Prof.

ODAMAKI, Toshitaka

Professor

NODA, Takeshi
AFFILIATION：
Institute for Life and Medical Sciences

Assoc. Prof.

SUGITA, Yukihiko

Assist. Prof.

NAKANO, Masahiro

Assist. Prof.

MURAMOTO, Yukiko

Main theme
Our laboratory aims to elucidate thereplication mechanisms of human pathogenic
viruses, such as influenza virus, Ebola virus,
and SARS-CoV-2, for the prevention andtreatment of viral infectious diseases. To thisend, we use several cutting-edge techniquessuch as cryo-electron microscopy, electron
tomography, and high-speed atomic force
microscopy to visualize virus entry,
replication, assembly, and virus formation. In
addition, we use human respiratory organoids
to understand virus replication and the host
responses in human respiratory organs. We
also develop novel therapeutics for deadly
viruses such as Ebola virus.

Lab URL

21

Graduate School of BIOSTUDIES, Kyoto University

Scanning electron micrograph of Ebola
viruses budding from cell surface.
Distinctive differences in ecological distribution ofbifidobacteria (HRB vs non-HRB).

https://www.facebook.com/NodaLab/

Graduate School of BIOSTUDIES, Kyoto University

22Division of Systemic Life Science ｜ Department of Molecular and System Biology

Division of Systemic Life Science ｜ Department of Animal Development and Physiology

Laboratory ofSingle-Molecule
Cell Biology

Assoc. Prof.

SAKAMAKl, Kazuhiro

Laboratory of
Molecular andCellular Biology

Main theme
Professor

WATANABE, Naoki
Senior Lecturer

YAMASHIRO, Sawako

Assist. Prof.

MIYAMOTO, Akitoshi

Main theme
Our laboratory aims at bridging the gap
between molecular activities and cell
physiology by visualizing signaltransduction and cell structure
remodeling processes with live-cell
fluorescence single-molecule(eSiMS) microscopy. We also invented
new super-resolution microscopy called
IRIS, which achieves unprecedented
ultra-high density (= high-fidelity)
labeling of multiple targets in a single
specimen. Furthermore, real-time

imaging revealed an unexpected
allosteric effect of anti-cancer kinase
inhibitors, which may potentially convert
inactive oncogenic kinases into an
activated state. By real-time andhigh-resolution monitoring of cellstructure and adhesion molecules using
these advanced optical techniques, ourlaboratory unveils mechanisms anddynamics of pathophysiological cellsignaling, drug actions and bodystructure remodeling.

Apoptosis, or programmed cell death, plays animportant role in many biological processes,
including embryogenesis, maintenance oftissue homeostasis, and elimination of
improper cells such as unfunctional or harmful
cells in both animals and plants. Our main
research project is to understand themolecular and cellular mechanisms ofapoptotic cell death in vitro and in vivo, using
cultured cells, medaka and mouse as model
systems. We also investigate to develop new
methods and techniques for imaging andsimulating of such a vital phenomenon. In
conjunction with these studies, we have beenchallenging to pursue the biologicalsignificance of cell death.

http://www.MCB.lif.kyoto-u.ac.jp//

Lab URL

Assoc. Prof.

TAKAHARA, Kazuhiko

Main theme
Our interest is the induction and control of
immunity. We focus on dendritic cells (DC),which are a primary antigen-presenting cell in
the immune system. We are especiallyinterested in functions of lectin molecules
expressed on DC and its relative, macrophage,that recognize polysaccharides on pathogenic
agents. The study includes analyses ofinteraction between polysaccharides andLab URL

23

Graduate School of BIOSTUDIES, Kyoto University

http://www.pharm2.med.kyoto-u.ac.jp/

Mouse lectins expressedon DCs/macrophages

Laboratory of
Immunobiology

lectins, and subsequent cellular and systemic
responses in co-operation with TLR signaling. In
this study, we found that certain
lectin-polysaccharide interaction induced
immune suppressive environment, amelioratingexcessive and lethal inflammation. By thesestudies, we would like to develop new methods
to control immune system.

http://zoo.zool.kyoto-u.ac.jp/imm/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

24Division of Systemic Life Science ｜ Department of Animal Development and Physiology (Collaboration Course)

Laboratory of
Molecular Cell
Biology andDevelopment
Visiting Professor

KITAJIMA, Tomoya

GBS’ s Collaboration Course in the RIKEN KOBE BDRTAKASATO, Minoru

Meiosis in oocytes is prone to chromosome
segregation errors and thus frequently
produces aneuploid eggs. The aneuploidy ofeggs is a leading cause of pregnancy loss andcongenital diseases such as Down syndrome.
We aim to understand the causes ofchromosome segregation errors in oocytes.
We will reveal molecular mechanisms of how
unique features of oocytes and age -related
effects predispose to chromosome
segregation errors. The mechanisms in
oocytes will be compared with those in eggs
and zygotes, by which we will understanddifferentiation of intracellular mechanisms
through development. By understanding how
aging affects chromosome segregation in
oocytes, we will provide insights into how
events at cell, tissue and organ levels areinterconnected at different life stages.

OBATA, Fumiaki

KIMURA, Ikuo
Main theme

Prometaphase belt of chromosomes

http://chromosegr.riken.jp/index_en.html

Our research aims at understanding themolecular mechanism of homeostasis
maintaining, especially focuses on
dietary/nutritional function, endocrine
metabolism, and cancer. Based on thisresearch, we aim to provide valuable
insight into the development of functional
foods, supplements, and medicinal drugs.

1. Dietary signaling via nutrient-sensing
receptors and metabolic syndrome

Assist. Prof.

OHUE, Ryuji

2. Non-genomic effects via sex steroid
hormone receptors and neurologicaldisorders

Assist. Prof.

IKEDA, Takako

In our previous study, we developed a protocol
generating self -organizing kidney organoids
from human iPS cells. While these kidneyorganoids comprise all anticipated renal
tissues, they are still far from the real humankidney in terms of their size, tissue complexity,
maturity and functionality. We study to achieve
the ultimate goal of generating a functional
and transplantable three -dimensional kidney.
We appreciate knowledge from basic
developmental biology that is essential forsuch regenerative studies; therefore, we arealso highly interested in studies of humanembryology. Particularly, we are focusing on
uncovering the developmental mechanisms of
the human mesoderm and kidney.

A kidney organoid generated fromhuman pluripotent stem cells

https://www.bdr.riken.jp/en/research/labs/takasato-m/index.html

Main theme
Nutrition and gut microbiota are vital players
for organismal homeostasis and therefore
influence our healthspan. Diet contributes tometabolic and physiological homeostasis byaltering nutritional balance and gut microbiota,
however our understanding of the molecularmechanism is far from complete. Ourlaboratory studies the functions of eachnutrient and gut bacterial species using amodel organism Drosophila melanogaster. We
also aim to elucidate mechanistically how
early -life diet alters life -long health. Our goal isto reveal evolutionally -conserved “dietological"
mechanisms that govern organismal ageing
and lifespan.
Lab URL

25

Professor

Main theme

Lab URL

Visiting Assoc. Prof.

Laboratory of
Molecular
Neurobiology

Main theme

Lab URL

Visiting Assoc. Prof.

Division of Systemic Life Science ｜ Department of Signal Transductions

Graduate School of BIOSTUDIES, Kyoto University

Drosophila intestine and gut microbiota

https://www.bdr.riken.jp/en/research/labs/obata-f/index.html

http://www.biosystem.lif.kyoto-u.ac.jp/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

26

Division of Systemic Life Science ｜ Department of Signal Transductions

Division of Systemic Life Science ｜ Department of Functional Biology

Laboratory of
Functional
Biology

Laboratory of
Genetics

Professor

Professor

IGAKI, Tatsushi
Assoc. Prof.

KANDA, Hiroshi

KAKIZUKA, Akira
Main theme

Research subjects

Main theme

Our research focuses on the molecular basisof cell-cell communication that governs
tissue growth, homeostasis, and cancer. We
take advantage of the powerful genetics ofDrosophila.

1. Mechanism of cell competition

Using animal models of human diseases,
such as neurodegenerations, cancers,
and obesity-related diseases, and using
metabolite imaging techniques, we aim toelucidate molecular bases of suchdiseases and develop new strategies tocure or prevent them.
One of the main features of life science
research in the coming years will be thatthe results obtained from fundamental
research should ideally be directly
connected to the good of society. From
this standpoint, in addition to handling

2. Genetic basis of tissue growth regulation
3. Molecular basis of tumor progression andmetastasis
4. Mechanism of aging

Assist. Prof.

ENOMOTO, Masato

topics with high scientific significance,
we aim to contribute to the developmentof treatments for neurodegenerative
diseases, cancers, and obesity-relateddiseases from our research results.
We hold the same view on scientificeducation, and through training
individuals to communicate their ideas
logically yet effectively, as well as bynurturing their creativity, in addition tostrengthening their practical researchskills, we aim to cultivate opinion leaders
standing at the core of life science
research in the 21st century.

Assoc. Prof.

IMAMURA, Hiromi

Assist. Prof.

KOIKE, Masaaki

Left: Polarity-deficient cells (green; losers) are eliminated from epithelium by wild-type cells (magenta;
winners) through cell competition.
Right:Malignant tumor cells (magenta) are invading and metastasizing from the eye disc to the brain(blue) in Drosophila larva.

Lab URL

27

Graduate School of BIOSTUDIES, Kyoto University

https://igakilab.lif.kyoto-u.ac.jp/english/

http://www.funcbiol.lif.kyoto-u.ac.jp/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

28

Division of Systemic Life Science ｜ Department of Biology Education and Heredity

Laboratory of
ScienceCommunication

Specially Assigned Professor

Assoc. Prof.

Assoc. Prof.

GUY, Adam Tsuda

CARLTON, Peter

Main theme

research. Our activities entail the following:

Main theme

Our laboratory engages in the development
and implementation of new approaches to theinternationalization of science education andcommunication, based on principles of active
learning. The particular challenges we are
addressing often involve overcoming thedifferences in culture and pedagogicaltraditions between Japanese and Western
societies. Our efforts are chiefly in the
educational arena, aimed at training the next
generation of scientists to communicate theirknowledge and expertise not only to theinternational scientific community but locallyto the citizens who ultimately support basic

1. Increasing the exposure of Japanese
students to foreign peers. We are forging
new partnerships with foreign universities
to foster joint courses, using live Internet
connections, with active student
participation in English.

To create haploid gamete cells (sperm or egg
cells) from diploid precursors in meiosis,
homologous chromosomes must pair, recombine,and then separate from each other, reducing the
genome by half.
Recombination between homologous
chromosomes is initiated in meiotic prophaseby programmed DNA double-strand breaks;
these breaks are then repaired throughhomologous recombination, giving rise to
genetic crossovers that link homologous
chromosomes until they divide.
Using the model organism Caenorhabditis elegans,
we are working to determine the molecularmechanisms of recombination initiation and repair
in the context of chromosome dynamics,

3. Expanding the opportunities for students
to present their research in English to abroad audience.

combining molecular genetics, biochemistry andcytology with high-resolution microscopy andquantitative image analysis. Since errors duringmeiosis are common in humans and can lead toinfertility and developmental defects,
understanding these mechanisms is important
for achieving improvements in humanreproductive health.
Our current research focuses on the following areas:- Understanding mechanisms of programmed DNA
double-strand break initiation during meiosis- Phosphoregulation of the synaptonemal complex- Analysis of chromosome structures using
super-resolution microscopy

http://www.carltonlab.org

How does protein phosphorylation regulate liquid-liquid phase separation?

Lab URLThis finding was published in Nature Cell Biology on May 5th, 2022.
The research group of Shige H. Yoshimura (GSB, Kyoto
Univ.), Hiroya Yamazaki (former Ph.D. student in GSB,
Kyoto Univ., and current Assistant Professor in Univ. ofTokyo), Tatsuya Hirano (RIKEN), Masatoshi Takagi(RIKEN), and Hidetaka Kosako (Tokushima Univ.)
revealed the mechanism of how protein
phosphorylation, one of the most important
post-translation modifications, regulates liquid-liquid
phase separation, which plays pivotal roles in theformation and dissolution of intracellular
membrane-less organelle such as nucleolus.
Phosphorylation has been known to regulate proteinfunction via stereo-specific effect. However, it was notwell understood how it affects the function andbehavior of non-structured (intrinsically disordered)proteins in an intracellular milieu. The groupdemonstrated that the addition of negative charges byphosphorylation increases or decreases the charge
segregation pattern, “charge block” , along thedisordered polypeptide and enhances or suppresses theliquid-liquid phase separation, respectively. This finding
provides a mechanistic linkage between
post-translational modifications and liquid-liquid phaseseparation. The nucleolus is an intracellular
membrane-less organelle that plays critical roles in thecell cycle, cell proliferation, stress response, innate
immune system, and viral replication. The group’ s new
finding will contribute to the understanding of themechanism of those cellular events, as well as to thedevelopment of new treatments for the dysfunction of
those cellular processes.

Innovative Technology Expands Applications of Monoclonal Antibodies-Rapid conversion of monoclonal antibodies to multiplexed super-resolution imaging probesThis work was published online in Cell Reports Methods on September 20, 2022 (local time).

https://www.nature.com/articles/s41556-022-00903-1

Super-resolution microscopy called IRIS, which uses
fluorescent probes that rapidly bind and dissociate to thetarget molecules, produces high-density, high-fidelity
images of molecular distributions that cannot be achieved
with conventional antibody staining. IRIS overcomes the“super-resolution dilemma” problem, known for grainy,
discontinuous images due to the limited labeling density
by conventional antibody staining (Nature Methods 12:743-746, 2015). However, it was not an easy task forresearchers to create IRIS probes for individual targets.
A research group led by Professor Naoki Watanabe of
Kyoto University Graduate School of Biostudies (alsoProfessor at Graduate School of Medicine), AssistantProfessor Akitoshi Miyamoto, and PhD student Qianli
Zhang, in collaboration with Professor Junichi Takagi ofInstitute for Protein Research, Osaka University, hasdeveloped a method to rapidly produce fluorescent probes

You can find an explanation video here

For further information, please refer to the URL below.

For further information, please refer to the URL below.

https://www.youtube.com/watch?v=mEUWk451FBU

29

2. Establishing partnerships with foreign
universities to encourage short-term
reciprocal exchanges of graduate
students for collaborative research.

Laboratory of
Chromosome
Functionand Inheritance

Graduate School of BIOSTUDIES, Kyoto University

optimized for the unlimited multiplexed super-resolution
microscopy IRIS by modifying existing antibodies. Many
proteins are present in thousands to several million percell. IRIS has the potential to visualize almost all positionsof each protein and compare the localization between
many types of proteins in a single super-resolved image. It
is expected to be a major step toward the practicalapplication and widespread use of IRIS microscopy.
By using the technology developed in this study, a large
number of monoclonal antibodies developed for medical
and research use can be efficiently converted into
fluorescent probes useful for IRIS super-resolution
microscopy and other types of multi-antigen detection
devices.

TOPICSTOPICSHEJNA, James Alan

Division of Systemic Life Science ｜ Department of Biology Education and Heredity

https://doi.org/10.1016/j.crmeth.2022.100301

Graduate School of BIOSTUDIES, Kyoto University

30Division of Systemic Life Science ｜ Department of Systems Biology

Division of Systemic Life Science ｜ Department of Systems Biology

Laboratory of
Bioimaging andCell Signaling

Professor

MATSUDA, Michiyuki（Concurrent post）
Main theme

Professor

MATSUDA, Michiyuki
Assoc. Prof.

KOBAYASHI, Taeko

Assist. Prof.

YUKINAGA, Hiroko

Main theme

Research objects

・Development of fluorescent andluminescent biosensors to visualize
signal transduction in living cells.
・Intercellular/intracellular signaling inliving cells and living mice.
・Live imaging of pancreatic cancer.
・Live imaging of glia.
・Analyses of proteostasis and lysosomal
regulation to maintain neural stem cells
in the adult brain.

https://sites.google.com/view/data-driven-biology/

Specially Assigned Professor

HONDA, Naoki

Lab URL

How leaders emerge from a cluster of cells:
The findings were published in “Developmental Cell” in October 2022.
By using fluorescence microscopy, the research groupled by Naoya Hino and Michiyuki Matsuda of the
Graduate School of Life Sciences discovered themechanism underlying leader cell specification duringwound healing. Cells that extend their legs, called
pseudopodia, toward the wound increase their
sensitivity to hepatocyte growth factor (HGF). HGF
further promotes pseudopodia formation and cell
migration through the activation of a signaling
molecule called ERK. Thus, cells that have first formed
large pseudopodia exhibit sustained ERK activationand emerge as leader cells.

whether the activation of receptors is promoted byextended pseudopodia, or whether a completely
different mechanism operates to increase thesensitivity to HGF."

TOPICS

Our research has been focused on thevisualization of activities of various
kinases and G proteins in living cells
using biosensors based on the principleof the Förster resonance energy transfer(FRET). Our most recent study created
FRET-based optogenetic tools whichenables molecular activity control atsingle-cell resolution. These sensors andoptogenetic tools will lead us to ‘talk’with live cells under microscope tofacilitate deeper understandings of thebiological systems. Multiphoton
microscopy of various tissues andorgans of mice expressing our biosensor
will reveal relationship between signaltransduction and cellular behavior inphysiological and pathologicalconditions.

Our laboratory aims to elucidate theoretical
logic of dynamic living systems. By
developing and simulating mathematicalmodels, we are trying to understandmechanisms underlying phenomena in abottom-up manner. We are also utilizing
machine learning to extract hidden rules ofdynamic, complicated phenomena fromexperimental quantitative data in a top-downmanner. By means of these theoretical
approaches, we are studying neuronal wiringin the brain, emotional neural dynamics,
noise-resistant embryonic development,
mechano-chemical mechanism of collective

cell migration, cytoskeleton-based cellularmorphogenesis, identification of intracellular
information processing and animal
behavioral strategy.

Laboratory ofTheoretical
Biology

Comment from researchers
In this study, we clarified the basic mechanism
underlying the emergence of the leader cells, but themechanism by which pseudopodia formation
increases sensitivity to HGF remains elusive. Growth
factors such as HGF activate receptors on the cell
membrane. We need to challenge the question of
Lab URL

31

Graduate School of BIOSTUDIES, Kyoto University

http://www.fret.lif.kyoto-u.ac.jp/mi.htm

Graduate School of BIOSTUDIES, Kyoto University

32

Division of Systemic Life Science ｜ Department of Systems Biology

Division of Systemic Life Science ｜ Department of Genome Biology

Laboratory of
GenomeMaintenanceLaboratory ofBrain Development
and Regeneration

Professor

Professor

IMAYOSHI, Itaru

Assoc. Prof. (Concurrent post)

GUY, Adam Tsuda

Assoc. Prof.

SAKAMOTO, Masayuki

MATSUMOTO, Tomohiro
Main theme
Our laboratory aims at understanding
the mechanisms of development andregeneration processes in the
mammalian brain, and their functional
outcomes on neural circuits, higher brain
functions, and animal behaviors. We arefocusing on the regulatory mechanismof cell growth, differentiation, andquiescence of neural stem cells. We arealso focusing on the functional

contribution of newly-generated neurons
to neural circuits and animal behaviors.
Our laboratory is also developing novel
optogenetic tools that can manipulate
gene expression of cells by light.

Main theme
The spindle checkpoint, our major
research subject, is a surveillancemechanism to regulate cellular
apparatus for compliance with this rule.
It is a unique negative feedback thatconverts/amplifies a physical signal
sensed by kinetochores (attachment of
the spindle and/or tension) andregulates the timing of the sister
chromatid separation. Mad2, a signal

carrier of this feedback, plays a vital rolein the spindle checkpoint. It is
specifically localized at unattachedkinetochores that are the origin of thecheckpoint signal. Mad2 targets CDC20
and inhibits its activity to promote sister
chromatid separation. We study Mad2, acentral player of the spindle checkpoint,
to reveal mechanisms, which regulate
the activity of Mad2.

Senior Lecturer

FURUYA, Kanji

Assist. Prof.

SUZUKI, Yusuke

Lab URL

33

Graduate School of BIOSTUDIES, Kyoto University

http://brainnetworks.jimdofree.com

http://www.rbc.kyoto-u.ac.jp/radiation_system/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

34

Division of Systemic Life Science ｜ Department of Genome Biology

Division of Systemic Life Science ｜ Department of Genome Biology

Laboratory ofCancer Cell Biology

Assoc. Prof.

IKURA, Tsuyoshi

Professor

HARADA, Hiroshi
Assoc. Prof.

NAM, Jin-Min

Program-Specific Assist. Prof.

MU, Anfeng

Main theme
Cells maintain their function andmorphology by exploiting a suitable
adaptive response system to diverse andcomplex tissue microenvironments.
Several lines of evidence have suggested
that hypoxic, acidic and nutrients-depleted
microenvironments exist in solid tumors
and induce malignant phenotypes andchemo/radioresistance of cancer cells(Figure 1). We aim to elucidate molecularmechanisms responsible for cellular

adaptive responses to the tumor-specificmicroenvironments and malignant
progression of cancer cells (Figure 2).
· Cellular adaptive responses to tumor
microenvironments, e.g. hypoxia· Molecular mechanisms underlying
malignant progression and chemo/
radioresistance of cancer cells

Main theme

Main research topics

The purpose of our research is to clarify therole of chromatin dynamics, which is required
for the DNA metabolisms such astranscription, DNA replication, and DNA repair.
In particular, we focus on the molecularmechanisms by which histone modifiercomplexes regulate the histone eviction as
chromatin remodeling machinery upon DNA
damage induced by ionizing radiation. Our goal
is to understand how histone eviction
activates DNA damage signaling pathways
and functions as an anti-cancer signaling.

· Memory of genomic damage

Laboratory of
Chromatin
Regulatory
Network· Cellular robustness in genomic stressresponse· Solution of energy metabolism
mechanism in specific cancer cell

· Regulatory mechanisms ofcarbohydrate metabolic pathway

http://house.rbc.kyoto-u.ac.jp/mutagenesis2/index1

Lab URL

The findings were published in the JCI Insight.

Figure 1: Hypoxic tumor cells (green) distant from blood vessels (blue)
are resistant to radiation-induced DNA damage (red).

Figure 2: HIF-1-mediated gene networks responsible for both adaptive
responses to hypoxia and malignant progression of cancer cells.

Lab URL

35

Graduate School of BIOSTUDIES, Kyoto University

Non-alcoholic steatohepatitis (NASH) is rising inparallel with the global obesity pandemic, effective
therapeutic strategies against the former are still
under development. In the paper published in JCI
Insight, Prof. Kimura at the Laboratory of Molecular
Neurobiology revealed that endogenous
medium-chain fatty acids (MCFA)-mediated
GPR84-signaling protected hepatic functions fromdiet-induced lipotoxicity using GPR84-deficient mice, amodel of high-fat diet (HFD)-induced obesity. Under
HFD conditions, hepatic MCFA levels markedly
increased and suppress lipotoxicity-induced
macrophage activation followed by hepatic fibrosis
without influencing hepatic steatosis. Additionally,administering medium-chain triglycerides (MCTs),
MCFAs (C10:0 or C12:0, but not C8:0), or GPR84
agonists effectively improved NASH in mousemodels. GPR84 acts as a receptor for MCFAs(especially C10:0 and C12:0) however, GPR84 has
been still considered as an orphan receptor, and thenutritional signaling of endogenous and dietary
MCFAs via GPR84 remains unclear. This study
formally demonstrated that orphan GPCR GPR84 is a
receptor for endogenous MCFAs. Additionally, MCFAs,
either endogenously synthesized or derived fromdietary MCTs, may play important roles in recognizing
nutrient excess and maintaining hepatic metabolic
functions through GPR84 activation. Collectively,
GPR84 modulation may be an effective strategy for
improving the progression of NASH.

TOPICS

Medium-chain fatty acids suppress lipotoxicity-induced hepatic fibrosis
via the immunomodulating receptor GPR84

For further information, please refer to the URL below.

https://insight.jci.org/articles/view/165469

http://www.rbc.kyoto-u.ac.jp/cancer_biology/

Graduate School of BIOSTUDIES, Kyoto University

36

Division of Systemic Life Science ｜ Department of Mammalian Regulatory Network (Cooperation Course)

Laboratory of
RNA Viruses

Division of Systemic Life Science ｜ Department of Mammalian Regulatory Network (Cooperation Course)

Laboratory of
Cell Division and
TOYOSHIMA, FumikoDifferentiation

Professor

Professor

TOMONAGA, Keizo

AFFILIATION：
Institute for Life and Medical Sciences

AFFILIATION：
Institute for Life and Medical Sciences

Assoc. Prof.

MAKINO, Akiko

Assist. Prof.

MATSUGO, Hiromichi

Main theme
All viruses utilize the mechanisms ofinfected cells to replicate and propagate
repeatedly. Therefore, studying viruses is not
only about understanding them, but also
about uncovering the foundations of life
more broadly. In our laboratory, weinvestigate the interaction between viruses
and life, such as how viruses replicate, why
they cause diseases, and how viral
infections have impacted our evolution.
Additionally, we apply the unique features ofviruses to develop viral vectors for gene andcell therapy. Specifically, our research
focuses on RNA viruses, such as
bornaviruses, influenza viruses and novel
coronaviruses.

・Analysis of the replication andpathogenicity of bornaviruses.
・Investigation of the evolutionary
significance of endogenous RNA viruses.
・Development of novel viral vectors using
the Borna disease virus.

https://t.rnavirus.virus.kyoto-u.ac.jp/

How cells break their DNA enough, but not too much—enabling genetic recombination during meiosis
Published online in eLife on June 27, 2022
Reproductive cells such as eggs and sperm areproduced by a special cell division called meiosis.
It is estimated that approximately 20% of persons ofreproductive age have infertility problems, oftencaused by incorrect chromosome segregation, making
an understanding of meiosis at a molecular level apressing need in our modern society. Biostudies
doctoral student Heyun Guo and colleagues in thelaboratory of Peter Carlton showed using thenematode C. elegans that the protein DSB-1 isregulated by phosphorylation to promote theappropriate amount of DNA double-strand breaks. It is
critical to regulate the level of DNA breakage, sinceeither too high or too low activity could result inincorrect outcomes of meiosis. However, themolecular mechanism of this regulation had remained
unclear. This study found that the DNA
break-promoting activity of DSB-1 is controlled by two
enzymes, PP4 phosphatase and ATR kinase, which

For further information, please refer to the URL below.

https://elifesciences.org/articles/77956

Graduate School of BIOSTUDIES, Kyoto University

adjust the amount of DSB-1 phosphorylation, keeping
its activity at just the right amount. The proteins
revealed in this study are found in all sexually
reproducing organisms, and therefore themechanisms are likely to be important for humanreproduction as well.

Figure caption
Structural prediction (AlphaFold) of the DSB-1/2/3
complex that includes DSB-1 (red); the residues
whose phosphorylation was shown to affect DSB-1
function are shown in magenta. Arrows indicate theconservation of the predicted trimerization interface
in several species.

Main theme

3. Application of physiological organ remodeling[Toyoshima Group] This group aims to clarify themechanism of organ remodeling during life stages.
In particular, we focus on organ remodelling during
pregnancy, obesity, and aging from the perspectivesof tissue stem cell dynamics, multicellular /multiorgan network, and mechanobiology. We also
aim to apply the mechanism of physiological organ
remodeling to regenerative and anti-aging medicine.

to regenerative medicine

Assoc.Prof.

VANDENBON, Alexis

4. CriMGET system: Gene targeting technology
5. Bioinformatics methodology for the analysis oflarge biological datasets
Assist. Prof.

ISHIBASHI, Riki

[Vandenbon Group] This group is developing
bioinformatics methodology for the analysis of large
biological datasets, including single-cell and spatialtranscriptomics data.

Assist. Prof.

Research subjects

KOBAYASHI, Yoshihiko

1. Maternal organ remodeling during pregnancy
and maternal-fetal interphase
2. Organ remodeling during obesity and aging

https://www2.infront.kyoto-u.ac.jp/Toyoshima-HP/index-En.html

Lab URL

Unveiling a novel mechanism for regulating gene expression in phytohormonesthat promote plant growthThis study was published in Nature Plants on December 15, 2022.
Brassinosteroids (BRs) are key plant hormones that play a
critical role in regulating various aspects of plant growth,
including organ elongation and vascular formation.
Despite their importance, the precise molecularmechanisms governing BR-mediated gene expression
remain largely unknown. In this study, a joint researchgroup led by Takuya Miyakawa and Takeshi Nakano has
uncovered the "DNA shape readout mechanism" by which
the master transcription factor BIL1/BZR1 binds to target
DNA sequences on gene promoters. Additionally, theresearchers have demonstrated that BIL1/BZR1 canrepress gene transcription when it binds strongly to thepromoter alone by the mechanism. These findings
suggest that the expression of BR-responsive genes, boththose responding specifically to BR and those respondingin coordination with environmental stimuli such as light, isdynamically regulated by the differential binding modes of

BIL1/BZR1 to the target sequence, and thus represents a
crucial step towards understanding the complex
mechanism underlying BR-mediated plant growth
regulation.

TOPICSTOPICSLab URL

37

Research Subjects

Figure caption
Regulation of plant gene expression in response tobrassinosteroids

For further information, please refer to the URL below.

DOI：https://doi.org/10.1038/s41477-022-01289-6

Graduate School of BIOSTUDIES, Kyoto University

38

Division of Systemic Life Science ｜ Department of Mammalian Regulatory Network (Cooperation Course)

Laboratory of
Cellular andMolecular
Biomechanics
Assist. Prof.

MAKI, Koichiro

Division of Systemic Life Science ｜ Department of Advanced Imaging (Industry-Academia Collaboration Course)

Laboratory of
Spatiotemporal
Optical Control

Professor

ADACHI, Taiji

AFFILIATION：
Institute for Life and Medical Sciences

Main themein tissue development and growth.

Our group aims to clarify the mechanisms by whichcells sense mechanical stimuli and regulate theiractivities in stem cell differentiation, tissue/organ
morphogenesis, and functional adaptation. To better
understand how these dynamical processes aremechano-regulated through complex hierarchicalstructure-function relationships, we are bridging
spatial and temporal scales ranging frommicroscopic (molecular and cellular level)
phenomena to macroscopic (tissue level) behaviors.
Based on multiscale biomechanics integrating
biomechanics and mechanobiology researches, we
combine modeling and simulation with experiments
to elucidate mechano-biochemical couplings in living
system dynamics.

2. Understanding the mechanisms of tissue
development and growth emerging frommulticellular dynamics.
3. Clarifying the mechanisms of tissue functional
adaptation in a mechanical environment byremodeling.
4. Elucidation of mechano-biochemical couplingmechanisms in mechanosensory cells.
5. Understanding mechanical behaviors of DNA in cell
nucleus and the impacts on gene transcription.

Main theme
Two-photon fluorescence microscopy has
become a powerful tool for deep imaging of
biological tissues. However, many biologicalphenomena in which intercellular interaction
and communication networks play a crucialrole are invisible because of insufficient
imaging performance of commercial
two-photon fluorescence microscopes. We aim
to make the invisible visible by creating novel
optical techniques. Our current research
focuses on the following subjects;

1. Development of femtosecond lasers forultra-deep imaging and their applications

Program-Specific Professor

ISOBE, Keisuke

2. Development of wide-field deep imaging
techniques using spatiotemporal control oflaser pulses and their applications
3. Development of 4-dimensional optical control
techniques using multiphoton patterned
illumination their applications

1. Biomechanics and mechanobiology studies of stem
cell differentiation, morphogenesis, and remodeling

TOPICSLab URL

https://www2.infront.kyoto-u.ac.jp/bf05/index-e.html"Updating the immunological memory based on predictive coding:Why does the immune system eliminate viruses but not food?"
The findings were published in the Journal of “ iScience ” .
Kana Yoshido and Honda Naoki (Laboratory ofTheoretical Biology) developed a mathematical model
explaining how immune system induces appropriate
response to various antigens. To address thisfundamental question in immunology, we hypothesizedthat immune system predicts antigen risk and updates
the prediction based on prediction errors inimmunological memory formation. By simulation, we
revealed factors determining response intensity andreproducd allergy onset and the effect of
immunotherapy. Our results will contribute to better
understanding of not only the mechanism of immune
discrimination but also diseases from immune system
malfunctions.

For further information, please refer to the URL below.

URL: https://www.lif.kyoto-u.ac.jp/j/research/research_results/cat29/2023-01-17/

39

Graduate School of BIOSTUDIES, Kyoto University

Graduate School of BIOSTUDIES, Kyoto University40Radiation Biology Center (RBC)
Radiation Biology Center, Kyoto University

Departments

Dept. of Radiation System Biology
We are pursuing mechanistic understanding of genetic
and epigenetic inheritance by analyzing regulation ofcentromere structure, various cell cycle check points,
and stress responses.
[Staff]

MATSUMOTO, Tomohiro (Prof.)
FURUYA, Kanji (Senior Lecturer)

Dept. of Mutagenesis
How does the cell maintain its integrity in response tovarious stress such as radiation or UV? What kind ofstrategy is employed? To solve these questions and to
elucidate mechanisms of cancer or lifestyle-relateddisorders, we focus on chromatin that is thecharacteristic of eukaryote's genome using proteomics
analysis of chromatin regulator protein complexes,
bioimaging, and mathematical and statistic approaches.
[Staff]Dept. of Late Effects Studies
We are studying (1) cellular and molecular mechanisms in
response to endogenous DNA damage and replicationstress, and (2) disorders caused by the defects in thesemechanisms such as Fanconi anemia and hereditarybreast and ovarian cancer. We employ technologies in vitro
recapitulation of pathologies with iPS cell lines derived frompatients, genome editing, and analysis of human materials.

Dept. of Genome Repair Dynamics
We are conducting studies on intracellular andextracellular factors that affect cancer radiation
sensitivity/resistance, such as genetics deficiencies
and tissue microenvironments. Our research focus isranging from molecular, cellular, and tissue levels toexperimental mice and further to cancer patients.
[Staff]Message from Director of the Center

HARADA, Hiroshi

Overview

The Radiation Biology Center (RBC) was founded in 1976 to promote

The research in the RBC is in large

basic research on biological effects of radiation. The RBC has beenpart strongly linked with users offulfilling its responsibilities as a hub for scientists in radiation biology

the CORE Program, but at the sameand its related research fields. The center was integrated withtime, each member of RBC pursues

Graduate School of Biostudies in 2018 to commence novel and deeper
research activities from this blessed position as a part of "Biostudies"science with their own research
direction.

looking into the vast areas of life sciences.

IKURA, Tsuyoshi (Assoc. Prof.)

HARADA, Hiroshi (Prof.)
NAM, Jin-Min (Assoc. Prof.)
KOBAYASHI, Minoru (Program-Specific Assist. Prof.)
MU, Anfeng (Program-Specifc Assist. Prof.)

Dept. of Chromosome Function and Inheritance
Using the model organism Caenorhabditis elegans, we
are working to determine the molecular mechanisms ofrecombination initiation and repair in the context ofchromosome dynamics. Understanding thesemechanisms is important for achieving improvements
in human reproductive health problems such asinfertility and developmental defects.
[Staff]CARLTON, Peter (Assoc. Prof.)

Dept. of Stress Response
We will elucidate what kind of molecular reactions
cells would display upon low dose irradiation in termsof stress response. Our main research targets are
regulatory mechanisms of chromatin dynamics,
translational regulation on ribosomes, acquired
resistance mechanisms to low dose irradiation.
[Staff]NAKAOKA, Hidenori (Assist. Prof.)

Reaserch Result
Aberrant activation of HIF-1 and p53 deficiency, which are both
recognized as hallmarks of cancers, induce malignancy andresistance to radiation therapy and chemotherapy.
But functional and mechanistic relationship remains unknown.
Department of Genome Dynamics found that ZBTB2 links
activation of hypoxia signaling and tumor suppressor
dysfunction, thereby promoting cancer aggressiveness, thus
Low Dose and Low Dose-rate Irradiation System

Optical In Vivo Imaging System

The 2nd RBC-CEA Joint Workshop

representing a target to treat p53-deficient cancers.
（Koyasu et al. EMBO Rep. 24:e54042. 2023.）

41

Graduate School of BIOSTUDIES, Kyoto University

Graduate School of BIOSTUDIES, Kyoto University

42

Center for Living Systems Information Science (CeLiSIS)
Center for Living Systems Information Science (CeLiSIS)

thereby leading data-driven life science. To achieve this goal,

including the DNA Data Bank of Japan (DDBJ) at the National

CeLiSIS collaborates with the Center for Innovative ResearchInstitute of Genetics, and the University of Zurich.

and Education in Data Science (CIREDS), affiliated with theInstitute for Liberal Arts and Sciences, the core facility
network including the Innovative Support Alliance for Life
Sciences (iSAL) and the North Campus Instrumental Analysis
Station (NOCIAS), other graduate schools, and institutes
across the university campuses. Moreover, CeLiSIS interacts
with other advanced external research organizations,Life science and related fields havegenome-related data from diverse species, ranging fromnow entered the era of "data-driven

microorganisms to animals and plants, has been rapidly

life science," which combines the

expanding. The training of young researchers to analyze suchacquisition of multifaceted large data

big data using informatics approaches has previously been

sets, using state-of-the-art

carried out separately by individual graduate schools or byequipment, with analysis. This

limited numbers of faculty members, and it has beendata-driven life science can be led bychallenging to strengthen education systems that integrate" two-way" human beings who not

the data acquisition and the information analysis. Therefore,

only acquire big data from biologicalthe Graduate School of Biostudies (GSB) has reorganized thesamples, but also analyze the data by themselves using

Research Center for Dynamic Living Systems andinformatics approaches to extract, understand, and utilize theestablished the Center for Living Systems Information

data to interpret the biological significance.

Science (CeLiSIS) on April 1, 2023, to foster the training of

To date, the Research Center for Dynamic Living Systems has"two-way" scientists on a university-wide basis. CeLiSIS also

played a major role in acquiring large amounts of image data

deals with data mining, statistics, mathematical modeling, inusing cutting-edge microscopy, analyzing this data tosilico simulations, and quantitative image analysis.

systematically understand biological phenomena, andCeLiSIS is the platform that consolidates and systematizes

providing practical education on informatics-based analyticalinformatics-based educational and research resources in life

methods. At the same time, however, gene analysis

science, which were previously scattered throughout Kyoto

instruments such as next-generation sequencers have been

University, and develops new programs in order to generate

developing dramatically, and their use has spread throughout

expert "two-way" researchers who can truly unite wet

life-science research; consequently, the volume ofexperimental approaches with informatics approaches,

From the left, a heatmap of gene expression analysis, a section of olfactory bulb, an image of neuronal primarily culture, a tSNE plot of single cell analysis.

43

Graduate School of BIOSTUDIES, Kyoto University• Basic course (master's degree equivalent)Students and technical staff at Kyoto University can learn
practical information analysis, based on their own
knowledge of experimental science.
• Life science DX course (doctoral course equivalent)This course fosters world-class “two-way” researchers.

Departments

Message from Director of the Center

UEMURA, Tadashi

Overview of educational activities

Strategic Education ProgramThis department plays a central role in consolidating
and systematizing educational and research resourcesthat were scattered throughout Kyoto University, and inpromoting collaborations with other graduate schools,
institutes, university core facilities and externalorganizations to develop practical DX education
methods, together with other departments in CeLiSIS.
[Staff]

To extract biological significance from big data
generated by next-generation sequencers, curricula
related to UNIX, R, Python, statistical basics, andvarious NGS analysis software are provided.
[Staff]1 faculty member (Prof.)
UEMURA, Tadashi (Prof.)
1 faculty member (Assoc. Prof.)

Computational and Systems Biology
This department provides curricula related toprogramming languages, ordinary differential equations,partial differential equations, basic statistics, linear
regression, nonlinear regression, machine learning,principal component analysis, and image analysis.
[Staff]Computational Genomics

IMAYOSHI, Itaru (Prof.)
SAKAMOTO, Masayuki (Assoc. Prof.)
YOSHIMURA, Shigehiro (Assoc. Prof.)
IMAMURA, Hiromi (Assoc. Prof.)
USUI, Tadao (Senior Lecturer)
SUZUKI, Yusuke (Assist. Prof.)

1 faculty member (Prof.)
YAMANO, Takashi (Assoc. Prof.)
NAKAOKA, Hidenori (Assist. Prof.)
HATTORI, Yukako (Assist. Prof.)
YOSHITAKE, Yoshihiro (Assist. Prof.)
INOUE, Keisuke (Assist. Prof.)
KUMETA, Masahiro (Assist. Prof.)
OHUE, Ryuji (Assist. Prof.)

Advanced Big Data Analysis
This department provides curricula related tomathematical modeling and predictive simulation, AI,data science related to single cell gene expression andgenome analysis, spatial transcriptomics, andlarge-scale database creation, as well as collaborative
research opportunities for doctoral students.
[Staff]

MATSUDA, Michiyuki (Prof.)
KOBAYASHI, Taeko (Assoc. Prof.)
1 faculty member (Assoc. Prof.)
YAMAHIRA, Shinya (Program-Specific Senior Lecturer)
YUKINAGA, Hiroko (Assist. Prof.)

A class scene (an in-person exercise style)

Graduate School of BIOSTUDIES, Kyoto University

44

Data

As of April, 2023

Activity of Students following graduation
Number of Students（ ＝10）*Students who pass Interim Exam will recieve master’ s degree.

total 267

Master’s degree holder
Employment

58%

AY2022

Employment of Doctoral degree holder
Promotion

Others38%

Academia

Industry

AY202233%

67%

AY2021

33%

67%

4%

57%

AY2021
1st year

2nd year83

3rd year78

27（ ＝10）

Number of International Students

Government-sponsored23

4th year

Personally funded

28

Japanese Students

46

7%

5th year51

AY2020

total 344%

AY2020

17%

83%
（ ＝5）

Number of Doctoral degree holder

International Students

0

54%

2%
（ ＝1）

Non-degree Students

total 69

36%

AY2022

3

24

AY202120

AY202021

Places of Employment
International Students Numbers
Asia
India
1
7
Korea
6
Taiwan29
China
1
Pakistan
2
Viet Nam
1
Hong Kong
2
Malaysia
3
Mongolia
1
Singapore

AfricaSouth Africa
Kenya
RwandaEgypt
EuropeRussiaSwitzerland
Oceania
Australia

1121

total 69
Middle East
TürkiyeLebanonMale-female ratio of students(As of April 1 , 2023)

femalemalemaster

51% (82)

49% (79)

doctorate

48% (51)52% (55)1
1South America
Chile
1
Argentina
1

1
1

1

North America
2
CanadaUSA
1
Mexico1*( )The numbers in parentheses indicate number of visiting academic staff.

* 〉
The numbers in brackets indicate affiliate academic staff, in addition to the regular staff.
Number of Faculty and Staff 〈Including Specially Contracted Fixed-Term Faculty and Staff

Faculty

Professor

15

（4）
〈7〉
45

total 63

Associate Professor Senior Lecturer Assistant Professor

19

（4）
〈3〉

Graduate School of BIOSTUDIES, Kyoto University

6

23

〈6〉

Staff

（ ＝10）

total 122

total 59

Administrative Staff Technical Staff

27

32

Business
ARKRAY, Inc. / AIREX INC. / AOYAMA & PARTNERS / Accenture Japan Ltd / ASAHI SOFT DRINKS CO. / ASAHI KASEI CORPORATION / ASAHI BREWERIES, LTD /AJINOMOTO CO.,INC. / Astellas Pharma Inc. / Nihon Emsco Co. Ltd. / AOHATA CORPORATION / ISHIHARA SANGYO KAISHA, LTD. / Idemitsu Kosan Co.,Ltd /SDS Biotech K.K. / NTT DATA CORPORATION / Osaka Gas Co., Ltd / Otsuka Pharmaceutical Co., Ltd. / Oyatsu Company Ltd. / Oriental Yeast Co., ltd. /OncoTherapy Science, Inc / GAKKEN HOLDINGS CO.,LTD. / Calbee, Inc. / Kawasumi Laboratories, Inc. / KEYENCE SOFTWARE CORPORATION. /KISSEI PHARMACEUTICAL CO., LTD. / Kyowa Kirin Co., Ltd. / KYOWA HAKKO BIO CO.,LTD. / KYORIN CO., LTD. / KYOKUTO PHARMACEUTICAL INDUSTRIAL CO., LTD /Creatures Inc. / GLICO NUTRITION CO.,LTD. / Gekkeikan Sake Company, Limited / KOSÉ Corporation / KOBAYASHI Pharmaceutical Co.,Ltd. /SAPPORO BREWERIES LTD. / Sunstar Inc. / Santen Pharmaceutical Co., Ltd. / Suntory Holdings Limited / SANYO FOODS Co.,Ltd. / GL Sciences Inc. /Genex Partners / Shionogi & Co., Ltd. / SYSMEX CORPORATION / Shiseido Company, Limited / CMIC CMO Co., Ltd. / CMIC HOLDINGS Co., Ltd. /Sumitomo Life Information Systems Co.,Ltd. / SEIWA KASEI Co,Ltd. / DAIICHI SANKYO HEALTHCARE CO., LTD. / DAIKIN INDUSTRIES, LTD. /Sumitomo Dainippon Pharma Co., Ltd. / Taiyo Kagaku Co.,Ltd. / Takanofoods Co., Ltd. / TAKARA BIO INC. / TAKII & CO.,LTD /Takeda Pharmaceutical Company Limited. / Chugai Research Institute for Medical Science, Inc. / CHUGAI PHARMACEUTICAL CO., LTD. /THE CHUGOKU ELECTRIC POWER CO.,INC. / TSUMURA & CO. / TEIKOKU SEIYAKU CO., LTD. / TEIJIN LTD. / TEIJIN FRONTIER CO., LTD. /Denka Company Limited. / DENTSU INC. / TOHO CO., LTD. / TOYO SHINYAKU Co.,Ltd. / SHIGA INTERNATIONAL PATENT OFFICE /TOYOTA MOTOR CORPORATION. / Torii Pharmaceutical Co., Ltd. / choseido Pharmaceutical Co.,Ltd. / Nikon Corporation / NICHIREI BIOSCIENCES INC. /Nissan Motor Co., Ltd. / Nisshin OilliO Group, Ltd. / NISSIN FOODS HOLDINGS CO., LTD. / NIPRO CORPORATION / Nihon M&A Center Inc. / Bank of Japan /NIPPON STEEL CORPORATION / NIDEC CORPORATION / JAPAN POST Co., Ltd. / NIHON L'ORÉAL K.K. / Net Protections, Inc. / Noevir Holdings Co., Ltd. /Nomura Securities Co.,Ltd. / HOUSE FOODS CORPORATION / Panasonic Corporation / East Nippon Expressway Company Limited / HIKARI TSUSHIN, INC. /Pigeon Corporation / Hitachi High-Tech Corporation / Fixpoint, Inc. / FUJIFILM Business Innovation Corp. / FUJIREBIO Inc. / BLEACH / Marudai Food Co.,Ltd. /Maruho Co., Ltd. / MANDA FERMENTATION CO.,LTD. / mandom corp. / Mizuno Corporation / Mizuho Financial Group, Inc. / Sumitomo Mitsui Card Co., Ltd. /MUFG Bank, Ltd. / Mediscience Planning Inc. / MORINAGA MILK INDUSTRY CO.,LTD. / Yakult Honsha Co.,Ltd. / Yahoo Japan Corporation / Euglena Co.,Ltd. /Eurofins Analytical Science Laboratories, Inc. / Yoshindo Inc. / Lion Corporation / Rakuten Group, Inc. / Recruit Co., Ltd. / Linical Co.,Ltd. /ROHTO Pharmaceutical Co.,Ltd. / Roche Diagnostics K.K / ROKKO BUTTER CO., LTD. / Works Applications Co.,Ltd. / WORLD INTEC CO.,LTD. / AGC Inc. /Cygames, Inc. / EY Strategy and Consulting Co., Ltd. / H.U. Group Holdings, Inc. / JCR Pharmaceuticals Co., Ltd. / JERA Co., Inc. / Mizkan Holdings Co., Ltd. /NBC Meshtec Inc. / NTT DOCOMO, INC. / The P&G Japan Limited / PwC. / SOLIZE Corporation / Waqoo,Inc. / WuXi Biologics.

OthersHokkaido University / The University of Tokyo / Kyoto University / Shiga University of Medical Science / Wakayama Medical University / Kumamoto University /Okinawa Institute of Science and Technology Graduate University (OIST) / Ministry of Education, Culture, Sports, Science and Technology /Ministry of Agriculture, Forestry and Fisheries / National Research and Development Agency RIKEN / Japan International Cooperation Agency /KYUSHU INTERNATIONAL UNIVERSITY HIGH SCHOOL. / Nara Institute of Science and Technology / Nagoya University / University College London /OSAKA UNIVERSITY.
Graduate School of BIOSTUDIES, Kyoto University

46

Professors Emeriti As of April 1, 2023

Total Revenue in Fiscal 2022
Category
Operational grants
MEXT Research Grants
Other Research Grants
Donations for Research
Funded Research
Collaborative Research
Others
Total

Total (yen)NameTotal Revenue

252,025,327
415,815,989

429,807,316

Apr 1, 1999

Mar 31, 2001

TAKEICHI, Masatoshi

Cell Recognition and Pattern Formation

Apr 1, 1999

Mar 31, 2002

OHYAMA, Kanji

Plant Molecular Biology

Apr 1, 1999

Mar 31, 2003

KUMAGAI, HidehikoApplied Molecular Microbiology

Apr 1, 1999

Mar 31, 2004

18.65%YANAGIDA, Mitsuhiro

Chromosome Transmission

Apr 1, 1999

Mar 31, 2005

Operational grants

IZUI, Katsura

Plant Physiology

Apr 1, 1999

Mar 31, 2005

NAKANISHI, Shigetada

NeuroscienceApr 1, 1999

Mar 31, 2005

YAMAMOTO, Kenji

Applied Molecular Microbiology

Apr 1, 1999

Mar 31, 2010

KOZUTSUMI, Yasunori

Membrane Biochemistry and Biophysics

Apr 1, 1999

Mar 31, 2012

8.14%

81,717,000

Others110,030,730
1,351,396,362

30.77%

31.80%

Funded Research

MEXT
Research Grants

4.06%

0.53%

Donations for Research

Other Research Grants

Successive Deans As of April 1, 2023

TAKEYASU, Kunio

Plasma Membrane and Nuclear Signaling

Apr 1, 1999

Apr 30, 2014

INOUE, Tan

Gene Biodynamics

Apr 1, 1999

Mar 31, 2015

INABA, Kayo

Immunobiology

Apr 1, 1999

Mar 31, 2016

YONEHARA, Shin

Molecular and Cellular Biology

Aug 1, 2001

Mar 31, 2018

SATO, Fumihiko

Molecular and Cellular Biology of Totipote

Aug 1, 1999

Mar 31, 2018

NISHIDA, Eisuke

Signal Transduction

Apr 1, 1999

Mar 31, 2018

NEGISHl, Manabu

Molecular Neurobiology

Apr 1, 1999

Mar 31, 2019HEJNA, James Alan

Science Communication

Nov 1, 2010

Mar 31, 2020

CHISAKA, Osamu

Bioeducation

Apr 1, 1999

Mar 31, 2022

ISHIKAWA, Fuyuki

Cell Cycle Regulation

Sep 1, 2001

Mar 31, 2023

TAKATA, Minoru

Genome Damage Signaling

Apr 1, 2018

Mar 31, 2023

FUKUZAWA, Hideya

Applied Molecular Microbiology

Apr 1, 1999

Mar 31, 2023

Laureates

Year

Honors

As of April 1, 2023

HonorsName

Periodfrom

to

OHYAMA, Kanji

Apr 1, 1999

Mar 31, 2001

YANAGIDA, Mitsuhiro

Apr 1, 2001

Mar 31, 2003

INABA, KayoApr 1, 2003

Mar 31, 2005

NISHIDA, Eisuke

Apr 1, 2005

Mar 31, 2009

YONEHARA, ShinApr 1, 2009

Mar 31, 2013

ISHIKAWA, Fuyuki

Apr 1, 2013

Mar 31, 2017

KAKIZUKA, Akira

Apr 1, 2017

Mar 31, 2021

FUKUZAWA, Hideya

Apr 1, 2021

Mar 31, 2023

IGAKI, Tatsushi

Apr 1, 2023

L Oréal-UNESCO For Women in Science International Awards

INABA, Kayo2014

Japan Prize

TAKEICHI, Masatoshi

2005

The Order of Culture

Medal with Purple Ribbon

Person of Cultural Merit

Japan Academy Prize

Member of the Japan Academy

47

Graduate School of BIOSTUDIES, Kyoto University

toBiosignals and Response

Collaborative
Research

54,800,000

Enrollment period
from

SASAKI, Ryuzo

6.05%

7,200,000

Laboratory

YANAGIDA, Mitsuhiro

2011

NAKANISHI, Shigetada

2015

YANAGIDA, Mitsuhiro

2002

NISHIDA, Eisuke

2010

INABA, Kayo2016

MATSUDA, Michiyuki

2023

YANAGIDA, Mitsuhiro

2004

NAKANISHI, Shigetada

2006

YANAGIDA, Mitsuhiro

2003

OHYAMA, Kanji

2008

KUMAGAI, Hidehiko

2012

SATO, Fumihiko

2012

NISHIDA, Eisuke

2016

TAKEICHI, Masatoshi

2000

NAKANISHI, Shigetada

2009

Graduate School of BIOSTUDIES, Kyoto University

48

North Campus

Campus MAP

Graduate School of Agriculture
Graduate School of Biostudies● Gene Biodynamics● Plant Molecular Biology

Main Campus● Biosignals and Response● Applied Molecular Microbiology

Institute for Integrated
Cell-Material Sciences (iCeMS)● Molecular Biology of Bioresponse● Plant Developmental Biology● Symbiotic and Coevolutionary Mechanisms● Developmental Neurobiology● Biochemical Cell Dynamics

Faculty of Agriculture Main Bldg

● Multidisciplinary Biology● Molecular and Cellular Biology of Totipotency

Faculty of Medicine Bldg G
South Campus Research Bldg

Hyakumanben(Graduate School of Biostudies)● Chromosome Transmission● Cell Cycle Regulation

Imadegawa St.

Hyakumanben● Cell Recognition and Pattern Formation

Kyodai Nogakubu-mae● Plasma Membrane and Nuclear Signaling● Molecular and Cellular Biology● Immunobiology

St.

● Molecular Neurobiology

Higa
shioji● Science Communication● Graduate School of Biostudies(Office)Research Bldg. No.16● Signal Transduction

Science Frontier
Laboratory

Clock Tower● Functional Biology● Chromosome Function

Higashiyama higashi ichijo

and InheritanceFaculty of
Medicine Bldg A● Single-Molecule Cellu
Ky

Biology

Main Gate

Graduate School of Agriculture
Graduate School of Biostudies

a

ak

ir
sh

Higashi-Ichijo St.
St. Kyodai Seimon-maeaw

Medicine Campus
Faculty of Medicine Bldg F

Higashioji St.

Graduate School of
Pharmaceutical
Sciences Main Bldg.

● Genetics● Bioimaging and Cell Signaling

Graduate School of Biostudies,
Radiation Biology Center

South Campus Research Bldg (Bldg. G)
Science Frontier Laboratory● Genome Maintenance● Cancer Cell Biology● Chromatin Regulatory Network

KonoedoriKonoe St.

Marikoji St.

Pharmaceutical
ScienceCampus

Univ.
Hospital
East
Campus Kyodai

Institute for Life andMedical Sciences Bldg. No.2

● Brain Development and Regeneration

Hospital-mae

Faculty of Medicine Bldg F● Cell Division and Differentiation● Spatiotemporal Optical Control

Institute for Life andMedical Sciences Bldg. No.3

● RNA Viruses● Ultrastructural Virology

Kasugakita St.

Institute for Life andMedical Sciences Bldg. No.1

Graduate School of Biostudies,
Radiation Biology Center● Cellular and Molecular Biomechanics

AccessKeihan Limited Exp. 47min

Demachiyanagi Station

Osaka Umeda Station

Hankyu Limited Exp. 41min

Kyoto Kawaramachi
StationOsaka Station

JR Special Rapid Service 29min

Osaka International
Airport (Itami)

Airport Limousine Bus 60min

Kansai International
Airport

JR Airport Express “Haruka” 75min

Kyobashi Station

Kyoto
Station

20min Walk
Shijo Kawaramachi
StationKyoto city subway
For Kokusaikaikan
10min

Kyoto city bus(201, 31) 20min

Imadegawa Karasuma
Imadegawa
StationIn front of a Kyoto station

Kyoto city bus(201) 15min

Kyoto city bus(206) 30min

Contact

Graduate School of Biostudies Kyoto Univ. 【Inquiries concerning entrance examinationand "Global Frontier in Life Science”】
Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501【Other Inquiries】

Student Affairs Section

Phone 075-753-9222
FAX
075-753-9229
Email kyomu@adm.lif.kyoto-u.ac.jp

General Affairs Section

Phone 075-753-9221 FAX 075-753-9247
Email soumu@adm.lif.kyoto-u.ac.jp

https://www.lif.kyoto-u.ac.jp/e/YoshidaCampus