2-P-098
Decreased expression of synapse-related proteins in the prefrontal cortex ofprenatal folate deficiency mice.
Misato Yoshikawa, Hiroaki Aso, Masahiko Watanabe, Katsuya Suemaru
Dept. of Public Health, Sch. of Pharm., Shujitsu Univ.

Copyright © The Japanese Pharmacological Society

2-P-099
Involvement of microglia in mechanical allodynia in a mouse model ofneurodevelopmental disorder
Eiji Imado1,2, Samnang Sun3, Abrar Abawa3, Satoshi Asano1,3, Yoki Nakamura4,
Kazue Nakashima4, Norimitsu Morioka4, Kazuhiro Tsuga3,5, Masahiro Irifune2,3,Kazuhiro Takuma6, Norikazu Kiguchi7, Yukio Ago1,3
1

Dept. of Cell. Mol. Pharmacol., Grad. Sch. of Biomed. Health Sci., Hiroshima Univ., 2Dept. of Dental Anesthesiol.,Grad. Sch. of Biomed. Health Sci., Hiroshima Univ., 3Sch. of Dent., Hiroshima Univ., 4Dept. of Pharmacol., Grad.
Sch. of Biomed. Health Sci., Hiroshima Univ., 5Dept. of Adv. Prosthodont., Grad. Sch. of Biomed. Health Sci.,
Hiroshima Univ., 6Dept. of Pharmacol., Grad. Sch. of Dent., Osaka Univ., 7Dept. of Physiol. Sci., Sch. of
Pharmaceut. Sci., Wakayama Med. Univ.

Copyright © The Japanese Pharmacological Society

2-P-100
Effects of adolescent social isolation and resocialization on the mOFC-BLA
synaptic transmission and social behavior in mice.
Hiroshi Kuniishi, Mitsuhiko Yamada
Dept Neuropsychopharmacolog, NCNP

Copyright © The Japanese Pharmacological Society

2-P-101
Reduced prefrontal hub function in brain networks associated with social
deficits of an ASD model mouse
Atsushi Kasai1, Yusuke Iyanaga1, Hiroki Ueno1, Yuka Nakai1, Yuta Hara1,2, Hiroki Miura1,
Masato Tanuma1, Misuzu Hayashida1, Rei Yokoyama1, Jin Ohkubo1, Kaoru Seiriki1,3,
Atsuko Hayata-Takano4, Shun Yamaguchi5,6, Shiho Kitaoka7,8, Tomoyuki Furuyashiki7,
Yukio Ago9, Takanobu Nakazawa1,10, Kazuhiro Takuma4,11, Hitoshi Hashimoto1,4,12,13,14
1

Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Div. Chemotherapy, Fac. Pharm., Kindai
Univ., 3Inst. Transdiscip. Grad. Degree Prog., Osaka Univ., 4Unit. Grad. Sch. Child Dev., Osaka Univ., 5Dept.
Morph. Neurosci., Grad. Sch. Med., Gifu Univ., 6G-CHAIN, Gifu Univ., 7Div. Pharmacol., Grad. Sch. Med., Kobe
Univ., 8Dept. Pharmacol., Hyogo Coll. Med., 9Dept. Cell. Mol. Pharmacol., Grad. Sch. Biomed. Health Sci.,
Hiroshima Univ., 10Dept. Biosci., Tokyo Univ. Agri., 11Dept. Pharmacol., Grad. Sch. Dentistry, Osaka Univ., 12Inst.
Datability Sci., Osaka Univ., 13Open Tarnsdiscip. Res. Initi., Osaka Univ., 14Dep. Mol. Pharmaceut. Sci., Grad. Sch.
Med., Osaka Univ.

Copyright © The Japanese Pharmacological Society

2-P-102
Neonatal blockade of NR2A-containing NMDA receptor induces
schizophrenia-related behaviors in adult rats
Hiroki Furuie, Mitsuhiko Yamada
Dept. Neuropsychopharmacol., Natl. Inst. Mental Health, NCNP

Copyright © The Japanese Pharmacological Society

2-P-103
Depressive-like behaviors and GABAergic dysfunction of the raphe nuclei inrats experienced pharmacological stress during early postnatal period.
Taku Yamaguchi1, Ryo Fukumori1, Mitsuhiro Yoshioka2
1

Dept. Pharmacother. Neuropsychopharmacol., Fac. Pharmaceut. Sci., Nagasaki Intl. Univ.,2Dept.
Neuropharmacol, Hokkaido Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P-104
CGRP induces anxiety-like behavior through degradation of dopamine withactivating MAOb/KLF11/p-HP1γ pathway
Fujiwara Kyoshiro, Narumi Hashikawa, Naoya Hashikawa, Yodai Shitanishi, Naoya Harayama,
Yamato Sato
Dept Life Sci Okayama Univ Sci Grad Sch Sci

Copyright © The Japanese Pharmacological Society

2-P-105
Possible involvement of the hippocampal microglia in the abnormalsociability lasting after tumor resection in mice
Yusuke Onaka, Yukinori Nakashima, Masanori Yoneyama, Taro Yamaguchi
Lab. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society

2-P-106
Brexpiprazole prevents colitis-induced depressive-like behavior by
regulating myelination through the activation of ERK1/2-CREB-BDNF-TrkB
pathway in the prefrontal cortex
Kohei Takahashi1, Lihua Hong1, Kazuhiro Kurokawa1, Kazuya Miyagawa1, Atsumi MochidaSaito1, Hiroshi Takeda2, Minoru Tsuji1
1

Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare, 2Dept. Pharmacol., Sch. Pharm. Fukuoka, Int. Univ.
Health and Welfare

Copyright © The Japanese Pharmacological Society

2-P-107
Chronic ocular dryness induces depressive-like behaviors in mice
Takayoshi Masuoka, Katsuya Nakano, Qiang He, Hitomi Nakazawa, Takeshi Kiyoi,
Junsuke Uwada
Dept. Pharmacol., Sch. Med., Kanazawa Med. Univ.

Copyright © The Japanese Pharmacological Society

2-P-108
Yokukansan, a traditional Japanese medicine, suppresses stress-induced
sympathetic activation and central responses to stress in rats
Naoko Yamaguchi, Makoto Fujikawa, Shoshiro Okada
Dept Pharmacol, Sch Med, Aichi Med Univ

Copyright © The Japanese Pharmacological Society

2-P-109
Decreased serotonin transporter in the prefrontal cortex induces anxiety-likebehavior
Ryota Araki, Akihiro Baba, Hayato Tachioka, Ayami Kita, Takeshi Yabe
Lab. Funct. Biomol. Chem. Pharmacol., Fac. Pharmaceut. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society

2-P-110
Decreased expression of Teneurin-4 in mouse hippocampus induces
depressive-like behavior
Yuichiro Sugimori1, Takashi Asano1, Naotaka Izuo1, Shin-Ichi Muramatsu2,3, Atsumi Nitta1
1

Dept. of Pharmaceut. Therapy & Neuropharmacol., Fac. of Pharmaceut. Sci., Grad. Sch. of Med. & Pharmaceut.
Sci. Univ. of Toyama, Japan, 2Div. of Neurological Gene Therapy, Open Innov. Ctr, Jichi Med. Univ.,3Ctr. for Geneand Cell Therapy, The Inst. of Med. Sci., The Univ. of Tokyo

Copyright © The Japanese Pharmacological Society

2-P-111
Short-term exposure to cuprizone impairs the development of adaptation tostress in mice
Kazuhiro Kurokawa1, Kohei Takahashi1, Kazuya Miyagawa 1, Atsumi Mochida-Saito1,
Hiroshi Takeda2, Minoru Tsuji1
1

Dept. Pharmacol., Sch. Pharm., Int. Univ. Health and Welfare, 2Dept. Pharmacol., Sch. Pharm. Fukuoka, Int. Univ.
Health and Welfare

Copyright © The Japanese Pharmacological Society

2-P-112
Vagus nerve spiking activity modulates prefrontal–amygdalar circuit related
to anxiety
Toya Okonogi1, Yuji Ikegaya1,2,3, Takuya Sasaki1,4
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo, 3CiNet, 4Dept
Pharmacol, Grad Sch Pharm Sci, Tohoku Univ

Copyright © The Japanese Pharmacological Society

2-P-113
Oxytocin treatment inhibits dexamethasone-induced depression by
activating the hippocampal CREB-BDNF signaling pathway in female miceShunsuke Kawanabe, Masayoshi Mori, Hiromi Shizunaga, Hiroyoshi Harada, Yusuke Murata,
Kenji Ohe, Munechika Enjoji
Dept. Pharmacother. Fukuoka Univ.

Copyright © The Japanese Pharmacological Society

2-P-114
Study on the Evaluation System of Lipopolysaccharide - Induced Depression
Model in Mice
Daichi Makabe, Yoshiyuki Hayashida, Saeko Yoshihara, Masana Kamioka, Takashi Tashiro,
Seiichi Katayama, Naoyuki Hironaka, Katsuhide Nishi
Kumamoto Laboratories, LSIM Safety Institute Corporation

Copyright © The Japanese Pharmacological Society

2-P-115
Effects of intranasal administration of CGRP on contextual fear memory
Yoneyama Yoshikazu, Narumi Hashikawa, Naoya Hashikawa, Rina Miyake, Yumi Morinaga
Dept . Life Sci , Okayama Univ . Sci . Grad . Sch . Sci .

Copyright © The Japanese Pharmacological Society

2-P-116
Endogenous oxytocin neuron projecting to the hippocampus participates in
the modulation of cognitive behavior
Junpei Takahshi1, Daisuke Yamada1, Yoshitake Sano2, Teiichi Furuichi2, Akiyoshi Saitoh1
1

Lab Pharmacol, Fac Pham Sci, Tokyo Univ of Sci, 2Lab Mol Neurosci, Fac Sci and Tech, Tokyo Univ of Sci

Copyright © The Japanese Pharmacological Society

2-P-117
Synaptic plasticity improved by GABA A receptor blockade are based on thechanged protein expression in hippocampus of a mouse model of Alzheimer‘s disease.
Keiichi Kadoyama1, Kenji Matsuura2, Masaoki Takano3, Takami Tomiyama4, Hiroshi Mori5,
Shogo Matsuyama6
1

Dept. Pharm. Health Care, Himeji Dokkyo Univ., 2Fac. Pharm., Osaka-Ohtani Univ., 3Sch. Pharm. Sci., Kobe
Gakuin Univ., 4Dept. Transl. Neurosci., Osaka City Univ. Grad. Sch. Med., 5Dept Clin. Neurosci., Osaka City Univ.
Med. Sch., 6Biosig. Res. Ctr., Kobe Univ.

Copyright © The Japanese Pharmacological Society

2-P-118
Theta phase precession induces hippocampal network plasticity
Miyake Kousaku1, Yuki Aoki1, Yuji Ikegaya1,2,3, Takuya Sasaki1,2,4
1

Lab Chem Pharmacol, Grad Sch Pharm Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo, 3CiNet, 4Dept Pharmacol,
Grad Sch Pharm Sci, Tohoku Univ

Copyright © The Japanese Pharmacological Society

2-P-119
Elucidation of the mechanism of cognitive decline in mild cognitive
impairment (MCI) using causal discovery
Kenji Matsuura1, Keiichi Kadoyama2
1Fac. Pharm., Osaka-Ohtani Univ., 2Dept. Pharm. Health Care, Himeji Dokkyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-120
The effect of trans-banglene, the active component of Indonesian ginger(bangle), on memory impairment in tauopathy mouse model
Takashi Kubota1, Shinya Matsuzaki1, Kenichi Harada2, Kentaro Nakashima3, Kyoka Tsukuda3,
Suzuna Nakazawa1, Karen Hagi1, Miwa Kubo2, Yoshiyasu Fukuyama2, Maki Yamada1,
Yasushi Kishimoto4
1Lab. Pharmacol., Kagawa Sch. Phrmaceut. Sci., Tokushima Bunri Univ., 2Fac. Pharmaceut. Sci., Tokushima Bunri
Univ., 3Inst. Neurosci., Tokushima Bunri Univ., 4Lab. Phys. Chem., Fac. Pharmaceut. Sci., Teikyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-121
Anti-amnesic effect of CUD 003, a novel synthetic derivative of curcumin, on
scopolamine-induced memory impairment in rats
Hirokazu Matsuzaki1, Chino Nakai1, Tatsuya Hirasawa1, Chifuyu Ohkubo1, Shota Kikuchi1,
Xuan Meiyan2, Jun Takayama2, Takeshi Sakamoto2, Yuan Bo1, Mari Okazaki1
1

Lab. Pharmacol., Fac. Pharm. Sci., Josai Univ., 2Lab. Org. Med. Chem., Fac. Pharm. Sci., Josai Univ.

Copyright © The Japanese Pharmacological Society

2-P-122
Involvement of hypoxia-inducible factor in postoperative cognitive
dysfunction
Daisuke Kodama, Yoshiaki Ohi, Akira Haji
Lab. Neuropharmacol., Sch. Pharm. Aichi-Gakuin Univ.

Copyright © The Japanese Pharmacological Society

2-P-123
Molecular mechanisms of REM sleep regulation: identifying protein-protein
interactions of NALCN channel through BioID technique
Tomoyuki Fujiyama1,2, Hikari Yamamoto1, Tomohiro Kitazono1, Aya Ikkyu1, Satomi Kanno1,
Miyo Kakizaki1, Jinhwan Choi1, Shinya Nakata1, Kazuya Murata3, Seiya Mizuno3,
Fumihiro Sugiyama3, Satoru Takahashi3, Hiromasa Funato1,4, Masashi Yanagisawa1
1

YF Lab, IIIS, Univ. of Tsukuba, 2Nat. Inst. of Neurosci., NCNP, 3LARC, Univ. of Tsukuba, 4Dept. of Anat., Med.,
Toho Univ.

Copyright © The Japanese Pharmacological Society

2-P-124
Characterization of multiple phosphorylation states of CaMKIIβ in
mammalian sleep regulation
Li Siying1, Daisuke Tone2, Koji Ode3, Hiroki Ueda2,3
1

Grad. Sch. of Frontier Biosci., Osaka Uni., 2Lab. for Synthetic Biology, RIKEN Ctr. for Biosystems Dynamics
Research, 3Dept. of Systems Pharmacology, Tokyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-125
Analysis of a novel gene involved in the maintenance of wakefulness inmammals
Wang Yimeng1,2, Rikuhiro Yamada2, Daisuke Tone2, Hiroki Ueda2,3
1

Grad. Sch. of Frontier Biosciences; Osaka Univ., 2Lab. for Synthetic Biology, RIKEN Ctr. for Biosystems Dynamics
Research, 3Dept. of Systems Pharmacology, Tokyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-126
Analysis of protein dephosphorylation underlying mammalian sleep-wakeregulation
Siyu Cao1,3, Daisuke Tone3, Rikuhiro Yamada3, Hiroki Ueda2,3
1

Graduate School of Frontier Bioscience, Osaka Uni., 2Department of Systems Pharmacology, Graduate School of
Medicine, Tokyo Uni., 3Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research

Copyright © The Japanese Pharmacological Society

2-P-127
Development of a novel Brain-Machine Interface by wide-field microscopy
Ibuka Kentaro1, Ryosuke Takeuchi1, Akinori Sato1, Kei Ito1, Masahiro Yamaguchi1,
Fumitaka Osakada1,2,3
1Lab. of Cell. Pharmacol., Grad. Sch. of Pharmaceut. Sci., Nagoya Univ., 2Lab. Neural Info. Proc., Inst. Adv. Res.,
Nagoya Univ., 3NLS, Inst. Inn. Fut. Soc., Nagoya Univ.

Copyright © The Japanese Pharmacological Society

2-P-128
Involvement of TRPV1 channels in hemokinin-1-induced nociceptive
behaviors
Takafumi Hayashi1, Syu-ichi Kanno2, Chizuko Watanabe3, Yasuyuki Agatsuma1, Akiyoshi Hara2,
Tsukasa Sakurada4, Shinobu Sakurada5
1

Div. Pharmaceutics, Fac. Pharmaceut. Sci., Tohoku Med. & Pharmaceut. Univ.,2Div. Pharmacotherap., Fac.
Pharmaceut. Sci., Tohoku Med. & Pharmaceut. Univ., 3Div. Physiol. & Anatomy, Fac. Pharmaceut. Sci., Tohoku
Med. & Pharmaceut. Univ., 4Fac. Pharmaceut. Sci., Daiichi Univ. Pharm., 5Fac. Pharmaceut. Sci., Tohoku Med. &Pharmaceu. Univ.

Copyright © The Japanese Pharmacological Society

2-P-129
Study on the involvement of TRPA1 and TRPV4 in cholestatic pruritus model
Takuya Hasegawa, Takuya Saisu, Kanto Fujihara, Koichi Kawahara, Takehiko Maeda
Dept. Pharmacol., Fac. Pharm. Sci., Niigata Univ. Pharm. Appl. Life. Sci.

Copyright © The Japanese Pharmacological Society

2-P-130
The involvement of selectin signaling in the sulfatide-induced mechanicalallodynia
Motoki Morita1,2, Shun Watanabe1,2, Natsumi Nomura1,2, Misa Oyama1,2, Takashi Iwai1,2,
Mitsuo Tanabe1,2
1Lab. Pharm., Sch. Pharm., kitasato Univ., 2Medical Research Lab.,Sch. Pharm.,Kitasato Univ.

Copyright © The Japanese Pharmacological Society

2-P-131
Novel small-molecule antagonists of Nr4a1 ameliorate mechanical allodynia
in neuropathic and bone cancer pain model mice
Ichiro Takasaki1, Mikiko Itoh1, Tsubasa Kuroda1, Serina Iso1, Takuya Okada2, Naoki Toyooka2,
Hiroaki Gouda3, Atsuro Miyata4, Takashi Kurihara4
1

Dept. Pharmacol., Grad. Sch. Eng. Sci., Univ. Toyama, 2Dept. Bio-func. Mol. Eng., Grad. Sch. Eng. Sci., Univ.
Toyama, 3Dept. Anal. Physic. Chem., Sch. Pharm., Showa Univ., 4Dept. Pharmacol., Grad. Sch. Med. Dent., Univ.
Kagoshima

Copyright © The Japanese Pharmacological Society

2-P-132
Neat1 lncRNA in primary sensory neurons is involved in microglial
activation in neuropathic pain
Motoyo Maruyama1,2, Atsushi Sakai1, Tsukasa Fukunaga3,4, Yoshitaka Miyagawa5,
Michiaki Hamada6,7,8, Hidenori Suzuki1
1

Dept. Pharmacol., Nippon Med. Sch., 2Div. Lab. Anim. Sci., Nippon Med. Sch., 3Waseda Inst. for Adv. Study.,
Waseda Univ., 4Dept. Comp. Sci., The Univ. of Tokyo, 5Dept. Biochem. and Mol. Biol., Nippon Med. Sch., 6Grad.
Sch. of Adv. Sci. and Eng., Waseda Univ.,7AIST-Waseda Univ. Comp. Bio Big-Data Open Innov. Lab. (CBBD-OIL),
8
Grad. Sch. of Med., Nippon Med. Sch.

Copyright © The Japanese Pharmacological Society

2-P-133
Pretreatment with RAGE inhibitor prevents the onset of nociceptive behavior
in mice with distal infraorbital nerve chronic constriction injury
Simeng Ma1, Yoki Nakamura1, Takahiro Kochi1,2, Kazue Hisaoka-Nakashima1,
Norimitsu Morioka1
1

Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Dept. Dent. Anesth., Grad. Sch. Biomed.
Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society

2-P-134
Effects of naftopidil on dorsal root evoked excitatory synaptic transmissions
in substantia gelatinosa neurons in vitro
Daisuke Uta1, Tsuyoshi Hattori2, Karin Yamada1, Kosuke Matsuda1, Masahito Sawahata1,
Toshiaki Kume1, Megumu Yoshimura3
1

Dept. Appl Pharm., Faculty Pharm Sci., Univ. Toyama, 2Asahi Kasei Pharma Co, 3Nogata Nakamura Hospital

Copyright © The Japanese Pharmacological Society

2-P-135
Effects of vanilloid analogues structurally related to capsaicin on the TRPV1channelYuki Oka, Kenji Takahashi, Toshio Ohta
Dept. Vet. Pharmacol., Fac. Agric., Tottori Univ.

Copyright © The Japanese Pharmacological Society

2-P-136
Identification of the site of production of complement C5, which isupregulated on exosomal bilayers from serum of mice with partial sciatic
nerve ligation
Kengo Hamamura, Masaya Kizushi, Marina Yamakawa, Kosuke Aritake
Chem. Pharmacol., Fac. of Pharmaceut. Sci., Daiichi Univ. of Pharm.

Copyright © The Japanese Pharmacological Society

2-P-137
Sex differences in modulatory function of arterial dilation by perivascularadipose tissue in metabolic syndrome
Satomi Kagota1,2, Kana Maruyama-Fumoto1, Risa Futokoro1, Kana Morikawa1,
Kazumasa Shinozuka1
1

Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ., 2Ins. Bio. Mukogawa Women's Univ.

Copyright © The Japanese Pharmacological Society

2-P-138
Effect of age on regulation of arterial tone by perivascular adipose tissue inrats with metabolic syndrome
Risa Futokoro1, Kana Maruyama-Fumoto1, Kana Morikawa1, Kazumasa Shinozuka1,
Satomi Kagota1,21

Dept. Pharmacol. II, Sch. Pharmaceu. Sci., Mukogawa Women's Univ., 2Ins. Bio. Mukogawa Women's Univ.

Copyright © The Japanese Pharmacological Society

2-P-139
Acamprosate attenuates atherosclerotic plaque formation and suppresses
oxidized LDL uptake by decreasing expression of LOX-1 and CD36
scavenger receptors.
Yamada Ayano1, Mitsuhisa Koga1, Jiro Takata1, Atsushi Yamauchi2
1

Dept. Drug Design and Drug Delivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Pharmaceut. Care & HealthSci., Fac. Pharmaceut. Sci., Fukuoka Univ.,

Copyright © The Japanese Pharmacological Society

2-P-140
Effect of tissue-type plasminogen activator on atherosclerosis in a mousemodel of hyper-LDL cholesterolemia
Tomohiro Arakawa, Takayuki Iwaki, Kazuo Umemura
Dept. Pharmacol., Hamamatsu Univ. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P-141
Moxifloxacin exacerbates aortic aneurysm and aortic dissection by
weakening the aortic media
Inada Koshun1, Mitsuhisa Koga2, Atsushi Yamauchi1
1

Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.,, 2Dept. Drug Design and Drug
Delivery., Fac. Pharmaceut. Sci., Fukuoka Univ.,

Copyright © The Japanese Pharmacological Society

2-P-142
Role of secreted protein acidic and rich in cysteine (SPARC) in vascularendothelial cell dysfunction and inflammation
Hiroe Toba, Miyuki Kobara, Tetsuo Nakata
Dept. Clin. Pharmacol.

Copyright © The Japanese Pharmacological Society

2-P-143
Carbonyl compounds in the gas phase extract of mainstream smoke derived
from heat-not-burn and combustion cigarettes cause vascular endothelial
dysfunction.
Takahiro Horinouchi1, Yuichi Mazaki1, Soichi Miwa2
1

Dept. Cell. Pharmacol., Grad. Sch. Med., Hokkaido Univ., 2Toyooka Gen. Hosp.

Copyright © The Japanese Pharmacological Society

2-P-144
Differences in vascular reactivity to soluble guanylate cyclase agonists
between female and castrated male pigs
Masashi Tawa, Keisuke Nakagawa, Mamoru Ohkita
Dept. Pathol. Mol. Pharmacol., Fac. Pharm., Osaka Med. Pharm. Univ.

Copyright © The Japanese Pharmacological Society

2-P-145
Docosahexaenoic acid (DHA) strongly suppresses TP receptor-mediatedcontractions of coronary and cerebral arteries in pig
Kento Yoshioka, Keisuke Obara, Shunya Ikawa, Kohei Uemura, Akina Yamaguch,
Kazuki Fujisawa, Hitomi Hanazawa, Guanghan Ou, Keyue Xu, Yoshio Tanaka
Dept. Chem. Pharmacol., Facul. Pharmaceut. Sci., Toho Univ.

Copyright © The Japanese Pharmacological Society

2-P-146
Upregulation of NR4A1 Protects Cyclic Mechanical Stretch-Induced Cell
Death in Rat Aorta Smooth Muscle Cells
Jing Zhao, Kiichi Nakahira, Yoji Kyotani, Masanori Yoshizumi
Department of Pharmacology, Nara Medical University School of Medicine Nara, Japan

Copyright © The Japanese Pharmacological Society

2-P-147
PKCβ inhibitor blocked angiotensin II-induced vascular smooth muscle
proliferation and oxidative stress
Sayaka Naganishi1, Masashi Mukohda1, Sho Nakamura2, Tosiyasu Matsui3, Risuke Mizuno1,
Hiroshi Ozaki1
1

Lab of Vet Pharm, Fac of Vet Med, Okayama Univ of Sci,2Lab of Animal Sci, Fac of Vet Med, Okayama Univ of
Sci, 3Lab of Anatomy, Fac of Vet Med, Okayama Univ of Sci

Copyright © The Japanese Pharmacological Society

2-P-148
The Anticonvulsant effect of flopropione does not involve catechol-O-methyltransferase (COMT) inhibition
Hoshiyama Mari1, Shiho Hasegawa1, Yumiko Mizukawa1, Yoko Amagase1,2, Tetsuro Urushidani1
1Dept. Pathophysiol. Fac. Pharmaceut. Sci., Doshisha Women's Coll. Liberal Arts, 2Osaka Med. & Pharmaceut.
Univ.

Copyright © The Japanese Pharmacological Society

2-P-149
Protective role of epithelial TRPV4 in the pathogenesis of OVA-induced foodallergy in mice
Murayama Yuki, Kenjiro Matsumoto, Hiroyuki Yasuda, Shinichi Kato
Dept. Pharmacol. Exp Ther., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society

2-P-150
Anti-inflammatory role of orphan G protein-coupled receptor GPR35 inexperimentally-induced murine ileitis and colitis
Motokawa Noriko1, Mikoto Tochioka1, Saki Sugimoto1, Koga Tokuyama1, Rika Ebara1,
Michiko Saito2, Hiroyuki Yasuda1, Kenjiro Matsumoto1, Shinichi Kato1
1

Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2Bio-Sci. Res. Ctr., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society

2-P-151
Peptidylarginine deiminase 2 (PAD2) contributes the pathogenesis of TNBSinduced murine colitis in relation to extracellular trap formation
Hiroyuki Yasuda1, Marino Shimomura1, Ayaka Uno1, Saya Koda1, Yoshiya Tanaka1,
Michiko Saito2, Kenjiro Matsumoto1, Shinichi Kato1
1

Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2Bio-Sci. Res. Ctr., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society

2-P-152
Protective effect of nafamostat mesylate on mucosal injury and 5hydroxytryptamine potentiation induced by a consecutive
administration of methotrexate to rats
Yamamoto Takahiro1, Takuji Machida1, Chiho Tanno1, Shiori Hasebe1, Sachiko Hiraide1,
Naoya Hamaue2, Kenji Iizuka1
1

Dept. Pharmacol. Sci., Sch. Pharm. Sci., Health Sci. Univ. of Hokkaido, 2Dept. Hygien. Chem., Sch. Pharm. Sci.,
Health Sci. Univ. of Hokkaido

Copyright © The Japanese Pharmacological Society

2-P-153
Effects of pemafibrate and bezafibrate on CDAHFD-induced murine
nonalcoholic steatohepatitis (NASH) model
Toshinori Moritani, Masanari Yoshimoto, Natsumi Hamada, Wakana Yamasuge, Noriko Minobe,
Shoko Kosugi, Hitomi Matsuda, Akihiro Ishimoto, Takashi Kise, Daisuke Saji, Akihito Ito,
Ayahito Kimura
NISSEI BILIS Co., Ltd., Shiga Lab.

Copyright © The Japanese Pharmacological Society

2-P-154
Development of new treatments based on commercial medicines for side
effects in cancer chemotherapy
Mitsutoshi Satoh1, Miku Motohashi1, Yayoi Kawano2, Takehisa Hanawa3
1

,2

,3

Copyright © The Japanese Pharmacological Society

2-P-155
Involvement of neutrophil and TRPV4 in the decreased colon function
elicited by long-term powdered diet feeding
Fukie Yaoita1, Masahiro Tsuchiya2, Koichi Tan-No1
1Div. of Pharmacol., Fac. of Pharmaceut. Sci., Tohoku Med. & Pharmaceut. Univ.,2Dept. of Nursing, Tohoku
Fukushi Univ.

Copyright © The Japanese Pharmacological Society

2-P-156
Analysis of microsomal Prostaglandin E syntase-1(mPGEs-1)/PGE2 axis
mechanism and relationship between regulatory T cells(Tregs) in promoting
granulation formation.
1,2

1

1

1

1

Hyodo Tetsuya , Hideki Amano , Yoshiya Itou , Kanako Hosono , Kou Hatanaka ,
3
4
5
6
2
Kouji Eshima , Izumi Hayashi , Satoshi Uematsu , Shizuo Akira , Akira Takeda ,7
Masataka Majima
1

Dept. of Pharmacol., Kitasato Univ. Sch. of Med., 2Dept. of Plast. and Reconst. Surg.,Kitasato Univ. Sch. of Med.,
Dept. of Immunol.,Kitasato Univ. Sch. of Med., 4Dept. of Med. Pharm., Nihon Pharm. Univ., 5Dept. of Immunol.
and Genom., Osaka City Univ. Graduate Sch. of Med., 6Lab. of Host Defense, IFReC, Osaka Univ., 7Dept. of Clinic.
Engin., Fac. of Health and Med. Sciences, Pathol. Treat. Lab., Kanagawa Inst. of Tech.
3

Copyright © The Japanese Pharmacological Society

2-P-157
Analysis of the mechanism by which TSLP production is inhibited by PHD
inhibitors
Makiko Yagisawa, Ryosuke Segawa, Naoyuki Tashiro, Noriyasu Hirasawa
Lab. of Pharmacother. of Life-Style Related Diseases, Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society

2-P-158
Study of anti-inflammatory Effects of Various Drugs on a Collagen-Induced
Arthritis Model in Mice
Yoshiyuki Hayashida, Masana Kamioka, Saeko Yoshihara, Takashi Tashiro, Naoyuki Hironaka,
Seiichi Katayama, Katsuhide Nishi
LSIM Safety Institute Corporation

Copyright © The Japanese Pharmacological Society

2-P-159
Inhibitory effect of REV-ERB agonist on inflammatory responses in primarycultured rat chondrocytes
Hashizume Hiroki1, Hatsune Motonari2, Yoki Nakamura1, Kazue Hisaoka-Nakashima1,
Norimitsu Morioka1
1

Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Sch. Pharmaceu. Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society

2-P-160
Increase in IL-10 expression by KCa3.1 inhibition mediating the JNK/c-Jun
signaling pathway in peripherally-induced regulatory T cells
Miki Matsui, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Susumu Ohya
Dept. Pharmacol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society

2-P-161
Cooperative action of IFN-γ and IL-4 to induce M2-like macrophages
Saki Shiga, Tomoko Endo, Natsumi Mizuno, Saeko Matsuda, Yoshiki Yanagawa
Department of Pharmacology, Health Sciences University of Hokkaido

Copyright © The Japanese Pharmacological Society

2-P-162
Effects of stretch-induced mechanical stimulation on macrophage function.
Masa-aki Ito, Kazuki Yoshida, Isao Matsuoka
Lab. Pharmacol., Fact. Pharm, Takasaki Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society

2-P-163
BRD6989, a CDK8/19 inhibitor, induces M2macrophages
Natsumi Mizuno, Saki Shiga, Yoshiki Yanagawa
Department of Pharmacology, Health Sciences University of Hokkaido

Copyright © The Japanese Pharmacological Society

2-P-164I

Copyright © The Japanese Pharmacological Society

2-P-165
Establishment of a novel atopic dermatitis mouse model using C57BL/6 mice
Masanori Fujii, Taisei Enomoto, Takato Ohtsuka, Rina Tanaka, Yuma Yasui, Satoshi Tanaka
Dept. Pharmacol., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society

2-P-166
Analysis of the pathogenesis of ICU acquired weakness (ICU-AW) in mice
Yuki Fujiwara, Midori Hoshizaki, Ryota Nukiwa, Mara Anais Llamas Covarrubias, Yumiko ImaiNational Institutes of Biomedical Innovation, Health and Nutrition

Copyright © The Japanese Pharmacological Society

2-P-167
Development of a noradrenergic neuron-selective AAV vector and its
application to the brain-wide axonal mapping
Kaoru Seiriki1,2, Shohei Yamada1, Shunsuke Maeda1, Yuzuka Fujimoto1, Atsushi Kasai1,
Hitoshi Hashimoto1,3,4,5,6
1

Grad. Sch. Pharmaceutical Sci., Osaka Univ., 2Inst. Transdisciplinary Graduate Degree Program, Osaka Univ.,
3
United Grad. Sch. Child Development, Osaka Univ., 4Inst. Datability Sci., Osaka Univ., 5Inst. Open andTransdisciplinary Research Initiatives, Osaka Univ., 6Grad. Sch. Med, Osaka Univ.

Copyright © The Japanese Pharmacological Society

2-P-168
Establishment of an in vivo calcium imaging method to evaluate neuronal
activity in mice carrying mutations of Arhgap10 gene
Rinako Tanaka1, Kazuhiro Hada1, Hiroyuki Mizoguchi1, Masahito Sawahata1, Taku Nagai1,
Daisuke Mori4, Toshitaka Nabeshima2, Kozo Kaibuchi3, Norio Ozaki4, Kiyofumi Yamada1
1

Dept. Neuropsychopharmacol. Hosp. Pharm., Nagoya Univ. Grad. Sch. Med., Nagoya, Japan, 2Adv. Diag. Sys. Res.
Lab., Grad. Sch. Health Sci., Fujita Health Univ., Toyoake, Japan, 3Dept. Cell Pharmacol., Nagoya Univ. Grad.
Sch. Med., Nagoya, Japan, 4Dept. Psychiatry, Nagoya Univ. Grad. Sch. Med., Nagoya, Japan

Copyright © The Japanese Pharmacological Society

2-P-169
Effects of genetic background on the phenotypic changes of p13 knockout
mice
Norihito Shintani1, Wakana Matsuo1, Satomi Hara1, Hiroki Ueno1, Hitoshi Hashimoto1,2,3,4,5
1

Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 2Unit. Grad. Sch. Child Dev., Osaka Univ.,
3Inst. Datability Sci., Osaka Univ., 4Open Tarnsdiscip. Res. Initi., Osaka Univ., 5Dept. Mol Pharmaceut. Sci., Grad.
Sch. Med., Osaka Univ.

Copyright © The Japanese Pharmacological Society

2-P-170
Cardiovascular dynamics of Zucker Fatty Diabetes Mellitus (ZFDM) rats, ananimal model of obesity and diabetes
Kosuke Otani, Risa Teranishi, Hiroshi Funada, Muneyoshi Okada, Hideyuki Yamawaki
Lab. Vet. Pharmacol., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society

2-P-171
Noninvasive monitoring of muscle atrophy and bone metabolic disorderusing Dual energy X-ray absorptiometry (DXA) in diabetes mellitus model
mouse
Goto Momo1, Kazuhisa Kishi1, Yoshiharu Tsuru2, Masatoshi Hori1
1

Dept. Vet. Pharmacol., Grad. Sch. Agri. Life Sci., The Univ. of Tokyo,2Primetech Corp.

Copyright © The Japanese Pharmacological Society

2-P-172
Evaluation of methods to analyze redox state in immune cells
Naomi Kamimura, Chikako Nito, Hiroshi Takahashi
Lab. Clin. Res., Collab. Res. Ctr., Nippon Med. Sch.

Copyright © The Japanese Pharmacological Society

2-P-173
Establishment of SARS-CoV-2 respiratory tract infection model in CAG
promoter-driven hACE2 transgenic mice
Utsumi Daichi1, Masamitsu Asaka1, Haruhiko Kamada2,3,4, Satoshi Nagata3, Yutaka Nakachi5,
Tomokazu Yamaguchi6, Yoshihiro Kawaoka7,8,9, Keiji Kuba6, Yasuhiro Yasutomi1
1

Tsukuba Primate Res. Ctr., NIBIOHN, 2Lab. of Biopharmaceutical Res., NIBIOHN, 3Lab. of Antibody Design.,
NIBIOHN, 4Global Ctr. for Med. Eng. and Informatics, Osaka Univ., 5Dept. of Mol. Brain Sci. Grad. Sch. of Med.
Sci., Kumamoto Univ., 6Dept. of Biochem. and Metabolic Sci., Grad. Sch. of Med., Akita Univ., 7Influenza Res. Inst.,
Dept. of Pathobiological Sci., Sch. of Veterinary Med., Univ. of Wisconsin,8Divi. of Virology, Dept. of Microbiol.
and Immunol. Inst. of Med. Sci., Univ. of Tokyo, 9Natl. Ctr. for Global Health and Med.

Copyright © The Japanese Pharmacological Society

2-P-174
Influence of differences in intratracheal administration methods on
phenotype
Nonomura Tohru, Ishida Yuki, Igarashi Masaharu, Nakajima Takuma, Yamazaki Noriyuki
New Drug Research Center Inc

Copyright © The Japanese Pharmacological Society

2-P-175
Elucidation of inhibitory pathway of guanylyl cyclase-B by sphingosine-1phosphate.
Katafuchi Takeshi1,2, Joseph Albanesi2
1

Div. of Biochem., Dept. of Biomed. Sci., Nihon University School of Medicine, 2University of Texas Southwestern
Medical Center

Copyright © The Japanese Pharmacological Society

2-P-176
Signaling pathway for proliferation effect of tri-deoxycytidine in neural stem
cells
Yamamoto Yuya1, Takahiro Ishimoto1, Keisuke Kiriyama2, Naoto Matsumura1, Yusuke Masuo1,
Mika Fujita2, Keita Sutoh2, Yukio Kato1
1Fac. Pharm., Kanazawa Univ., 2Fordays Co., Ltd.

Copyright © The Japanese Pharmacological Society

2-P-177
Hydrolytic activity of acid ceramidase on N-acylethanolamines, antiinflammatory and anorexic lipid mediators: an analysis using saposin Dknockout mice
Kazuhito Tsuboi1, Takashi Watanabe2, Keisuke Kitakaze1, Yasuhiro Takenouchi1,
Junko Matsuda2, Yasuo Okamoto1
1

Dept. Pharmacol., Kawasaki Med. Sch., 2Dept. Pathophysiol. Metabol., Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society

2-P-178
Up-regulated miR-199a-3p and miR-126-3p promote adipocyte differentiation
by targeting HIF-1α
Israt Jahan1, Takayuki Okamoto1, Haruki Usuda1, Tetsuya Tanaka2, Atsushi Nakajima3,
Koichiro Wada1
1

Dept. Pharmacol., Fac. of Med., Shimane Univ., 2Dept. Human Nutrition, Fac., Contemporary Life Science,
Chugoku Gakuen Univ., 3Dept. Gastroenterology and Hepatology, Yokohama City Univ. Grad. Sch. Med.

Copyright © The Japanese Pharmacological Society

2-P-179
Signal transduction mechanism for autocrine secretion of insulin-growth
factor type 1 by S-allyl-L-cysteine in primary cultures of adult rat
hepatocytes.
Hajime Moteki, Kazuki Kurihara, Masahiko Ogihara, Mitshtoshi Kimura
Josai Univ.

Copyright © The Japanese Pharmacological Society

2-P-180
Identification of weak-interacting proteins with Sav1 using BioID2 method
Uchida Kazuhiko, Nobuya Sakai, Katsushi Shibata
Div. Funct. Genomics. Fac. Pharmaceut. Sci. Himeji Dokkyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-181
Cytoprotective effect by Rab and PRAF proteins
Masahiko Watabe
Gen. Med. Educ. Res. Ctr. (G-MEC), Teikyo Univ.

Copyright © The Japanese Pharmacological Society

2-P-182
Analysis of sweat secretion by PACAP using human sweat gland
immortalized cells
Michio Yamashita1, Fumiko Takenoya1, Junko Shibato2, Randeep Rakwal3,
Takahiro Hirabayashi2, Yoshihiko Chiba4, Seiji Shioda5
1

Hoshi univ., 2Shonan Univ. of Med. Sci., 3Univ. of Tukuba, 4Hoshi univ., 5Shonan Univ. of Med. Sci.

Copyright © The Japanese Pharmacological Society

2-P-183
The crosstalk between Il-4/IL-13 and S1P/S1P2 signaling in phorbol estertreated THP-1 MΦsYasuo Okamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Shinya Yamamoto,
Hironobu Ishimaru, Kazuhito Tsuboi
Dept. Pharmacol., Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society

2-P-184
Development of a simple assay to measure glycerophosphodiesterase GDE4and GDE7 activities for screening their Inhibitors
Kitakaze Keisuke, Kazuhito Tsuboi, Maho Tsuda, Yasuhiro Takenouchi, Hironobu Ishimaru,
Yasuo Okamoto
Dept. of Pharmacol., Kawasaki Med. Sch.

Copyright © The Japanese Pharmacological Society

2-P-185
Antioxidative activity of ketamine as a direct free radical scavenger
Tokumaru Osamu1, Yuto Ozaki1,2, Taiki Kawano1,2, Kazue Ogata1, Nobuoki Eshima3,
Shigekiyo Matsumoto4, Takaaki Kitano4
1

Dept. Physiol., Fac. Welfare Health Sci., Oita Univ., 2Student, Phys. Ther. Trck., Fac. Welfare Health Sci., Oita
Univ., 3Dept. Ped., Sch. Med., Kurume Univ., 4Dept. Anesthesiol., Fac. Med., Oita Univ.

Copyright © The Japanese Pharmacological Society

2-P-186
Factors affecting medication adherence of older adults in acute care
hospitals receiving medication support by nurses
Kanako Sakane, Yuta Kobayashi, Saki Moriwaki, Ami Sato, Mayumi Miyamoto, Miki Fukuma,
Yuko Tsumoto
SHIMANE Uni., Fac. Med., Dept. Nursing

Copyright © The Japanese Pharmacological Society

2-P-187
Roxadustat enhances exercise performance in female mice
Sawada Shinichi1, Shota En1, Atsunobu Sugano1, Yukika Yamada1, Ayami Mori2,
Yoshiyuki Ishida2, Daisuke Nakata2, Keiji Terao2, Yoshinori Iba1
1

Dept. Life Sci., Fac. Sci. and Engineering, Setsunan Univ., 2CycloChem Bio Co., Ltd.

Copyright © The Japanese Pharmacological Society