GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITYINDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

8

Features of Education ………………………………………………………………… 10

Description of Lectures held in English ………………………………… 11
Outline and Composition of Departments …………………………… 16
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 17
Department of Gene Mechanisms ………………………………………………… 18
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Department of Cell and Developmental Biology ……………………………… 19
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 20
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 21
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 23
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 24
Laboratory of Genome MaintenanceLaboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 25
Laboratory of Molecular and Cellular Immunology
Laboratory of Developmental Dynamics
Laboratory of Ultrastructural Virology

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 27
Department of Molecular and System Biology…………………………………… 28
Laboratory of Single-Molecule Cell Biology
Laboratory of Bioimaging and Cell Signaling

INDEX

Department of Animal Development and Physiology ………………………… 29
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology and Development
Department of Signal Transductions ……………………………………………… 32
Laboratory of Molecular Neurobiology
Laboratory of Genetics
Department of Functional Biology ………………………………………………… 33
Laboratory of Functional Biology
Department of Biology Education and Heredity ………………………………… 34
Laboratory of Science Communication
Laboratory of Bioeducation
Laboratory of Chromosome Function and InheritanceLaboratory of Science Communication and Bioethics
Department of Mammalian Regulatory Network ……………………………… 36
Laboratory of Cell Regulation and Molecular Network
Laboratory of RNA Viruses
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information
Laboratory of Cellular and Molecular Biomechanics
Laboratory of Genome Damage Signaling
Laboratory of Cancer Cell Biology
Laboratory of Chromatin Regulatory Network

Organization ………………………………………………………………………… 41
Map & Access ……………………………………………………………………… 42
Contact ………………………………………………………………………………… 44

Greeting fromthe Dean of
the Graduate School
Dean: KAKIZUKA
KAKIZUKA, Akira
Akira, MD
MD, PhD

LET’S FIND YOUR TREASURE!
The Graduate School of Biostudies was establishedin 1999 as Japan’s first independent graduate school
focused on life science research and education with theobjective of developing individuals who can transcend
the existing frameworks of science, agriculture,pharmacology, and medicine to discover and apply
new knowledge related to biological phenomena. Asof the end of the last academic year, a total of 1,221
students had earned their master’s degree from ourschool, while 363 had earned their PhD; and thesegraduates are now contributing to life science researchand the development of industry across life sciencerelated fields. This is an achievement that brings
tremendous joy to all of the faculty members who
have been involved in research and teaching at theGraduate School of Biostudies since its inception.
I believe that the greatest mission of this graduate
school is to train exceptional PhDs. Since the majorityof those who are reading this message are probably
hoping to enroll in our school, I would like to offer mypersonal thoughts on earning a PhD (doctoral degree).
When I was a student in the medical school, I hada strong desire to work overseas in the future. Since aJapanese medical license is not accepted overseas, I
thought about going abroad as a researcher. To do so, I
realized I would need to earn a PhD, so after completing
my undergraduate degree, I immediately went on tograduate school and earned my PhD. When I explain
what a PhD is, I tend to compare it to a driver’s license.
For example, if you have an F1 license, you are allowed
to race F1 cars on circuits throughout the world. Similarly,
if you have a PhD, you are allowed to carry out researchat universities and research institutes around the world. I
believe there is no other qualification that enables you
to so freely do what you like. After I received my PhD, I
was hired for a postdoctoral position at the Salk Institute

4

GRADUATE SCHOOL OF BIOSTUDIES

for Biological Studies in the United States, where I wasable to enjoy living abroad as I had hoped and to gain
irreplaceable experiences. That was one of the mostenjoyable times of my life.
So how can you earn your PhD? In order to do that,you must first find your personal treasure that gets you
excited. It is like when you were a young child and you
got all excited about discovering a pretty marble or
seashell. But when it comes to this treasure, there aresome conditions. It should have an element of being
the “first in the world,” and the method for finding
this treasure should be through experimentation. The
more experiments you carry out, the faster you will findsuch a treasure. In particular, when you produce anunanticipated result, you could be closing in on a large
treasure, so it is important to verify your findings.
If you find your treasure, next you should teachothers about it. That entails writing papers. Writing papers
requires a bit of hard work, but you can ask senior
students and professors in your lab to advise you, so
there is absolutely no need to worry. After the paper has
been presented, if you write your doctoral thesis basedon that and successfully defend it, you will receive your
PhD, making you qualified to work at universities andresearch institutes around the world. You will then use
your experience to steadily find new treasures and write
more papers. That is the work of a researcher. It is fun!
Even if you do not become a researcher, I can assure
you that the experience and confidence you will gainfrom discovering something that nobody else in theworld knew about will serve you well no matter what
type of work you do. For that reason, I hope that as you
begin your graduate studies, you will devote all of yourefforts to conducting lots of experiments and discovering
your treasure. Then, once you have discovered yourtreasure, you can move on to your doctoral programwith your mind at ease, further polish your skills, andobtain your PhD. Waiting on the other side of that goalline, you will find an exciting life that far exceeds yourfor your future life. We, the members of the faculty, will

expectations. By all means, I hope that many of you will

dedicate ourselves to supporting your efforts and yourjoin our graduate school and will build the foundation

growth.

MISSIONS of our GRADUATE SCHOOLOPERATION POLICIES of our GRADUATE SCHOOL(1) Provide education for pursuing the new biostudies at(1) Training of individuals with the most advanced

the world's top level
To meet the demands of the industry, college,

knowledge of the life sciences for the next generation

research institutes and administrative organizations,

The graduate student studies a higher level of life

individuals are educated in the life sciences andsciences beyond the structures of past life science-

master the techniques for the society needs.

related fields at each undergraduate level to understand the integrated life sciences. The goal is to(2) Train individuals to apply the new life sciences fornurture a new type of individual with creative andthe protection of the global environment and for hu-

innovative abilities to cope with the various unknown

man welfare

themes to be confronted by human beings in the

Integrate the knowledge and technology innext generation.

the old fields of science, agriculture, medicine andpharmacology, and nurture individuals who cancontribute to the human society in the 21st century.

(2) Training to establish self for society
In the Graduate School of Biostudies, individuals
are trained to make a healthy and fair judgment(3) Nurture individuals who can understand the various

based on the academic background of the staff

vital phenomena of the living organisms as a sys-and their prospects for the future; and, establish atemic function, and pursue these systemic functions

new system to evaluate the effects of education

Nurture individuals who will be leaders in the humanfrom multiple aspects from the past.

society to pursue their activities for the welfare and happiness of humans in the 21st century, where humans will
be living in harmony with other living beings.

(3) Activation and flexibility of staff in the human relations
Research is pursued by each staff member independently to develop a new life science based on
active exchange among the various laboratories in
the graduate school.
(4) Use of current post-doctoral system and evaluationof academic activities
Full use should be made of the current system, toprovide the increasing necessary number of instructors per student, for the intensive training to become
life scientists at an international level, for true development of a new research field.

GRADUATE SCHOOL OF BIOSTUDIES

5

Policy
Admissions Policy

possess the pioneering spirit to help propel the

Mission and Desired Student Profile

comprehensive and advanced branches of the

As an advanced discipline that holds the key
to the future of humankind, the life sciences arelife sciences into new territory, while appreciating
the dignity of life.

currently undergoing a major evolutionary change.
The Graduate School of Biostudies was inaugu-

Curriculum Policies

rated in 1999 as the first independent school of its

1. The master's program provides a broad educa-kind in Japan with the mission of accelerating thistion spanning all domains of the life sciences,global trend, building a world-class center for re-and cultivates a foundation of competence forsearch, and training the human resources to leadoccupations that demand research abilities andthe life sciences field into the next generation. Ouradvanced expertise in specialized fields.

school has engineered a fusion of cutting-edge

2. The doctoral program endeavors to impartareas in several existing fields and harnessed thecutting-edge specialist knowledge backed bycommon languages of cellular and molecular biol-

diversified academic research, and to cultivate

ogy and genetics that together articulate the prin-independent researchers who can perform wellciples of life. Furthermore, it has developed an inte-

in an international setting. Additionally, it equips

grated understanding of diverse life forms and theadvanced professionals with the knowledge andenvironments they help shape, and has launchedskills required for occupations in specialized fields

innovative efforts in research and education that

as well as the ability to integrate those strengths

will define a new set of values for the future andand assume leading roles.

dignity of life.

3. Students develop the ability to accurately place

To meet the diverse expectations of society

their own research into perspective with theirfor advances in life science, which is becoming in-

specialization, discuss and debate the findings

creasingly sophisticated and complex, the Gradu-

and their significance in an international setting,ate School of Biostudies endeavors to cultivate hu-

and build frameworks for collaboration, as nec-

man resources with the following attributes.

essary.

1. Researchers ready to shed fresh light on, and

4. The curriculum is organized and implemented so

discover, the fundamental principles of life andthat students can apply broad visions to put theirpursue world-class research in new areas of theown research into perspective, build systems oflife sciences

knowledge, and pursue cross-disciplinary study

2. Researchers and advanced engineers commit-

unencumbered by existing fields of specializa-

ted to global environmental conservation andtion. This approach lays the groundwork for thegains in human health, welfare, and well-being,creation of new knowledge with which students

and ready to make social contributions throughwill be ready to tackle unknown fields with a tire-

roles in public and private research institutions

less spirit of innovation.

3. Educators and working professionals with a

5. As they pursue their research at deeper levels,

broad-based understanding of the varied phe-students develop the power to reflect on theirnomena of life in general and ready to makeown research with firm ethical integrity and asocial contributions through roles in education,strong sense of responsibility, and continually in-industry, the news media, and government

quire whether it is consistent with the harmonious

We seek students from a broad spectrum of

coexistence of humanity and nature.

backgrounds who share our values and desire to

6

continue their education through our programs.

Diploma Conferral Policies

We especially welcome students who are both

1. To be eligible for a degree, candidates in theknowledgeable and free of preconceptions, andmaster's program must be: enrolled for a mini-

GRADUATE SCHOOL OF BIOSTUDIES

mum of two years; complete courses offered bytence of humanity and nature.

the School, lab experiments, and practical train-

Doctoral candidates that excel in their re-ing; and attend seminars offered by the labora-

search performance may be deemed eligible for a

tory to which they belong. Candidates need

one-year minimum enrollment requirement insteadto acquire at least one credit hour in requiredof the three-year minimum mandated in item 3

subjects, nine credit hours in elective subjects,

above.

and 20 credit hours in lab experiments, practical training, and seminars. Candidates also must
pass a thesis review and examination administered by the School. To pass the review, the thesis must be logically and consistently written, andmust detail new discoveries or initiatives that willcontribute to insights and advances in the life
sciences.
2. As tangible benchmarks for successful completion of the master's program, candidates will
be expected to demonstrate that they haveacquired a wealth of scholarly knowledge andinsight, research ability in their field of specialization, and the foundation of competence for occupations that demand advanced expertise.
3. Doctoral degree candidates must be enrolled
for a minimum of three years as well as complete
courses offered by the School and seminars offered by the laboratory to which they belong.
Candidates need to acquire at least one credit
hour each in required and elective subjects andeight credit hours in seminars. Candidates also
must be granted research guidance approvaland pass a dissertation review and examination
administered by the School. The doctoral dissertation must be logically and consistently presented, and must detail new discoveries or concepts
that contribute to understandings and advancesin the life sciences.
4. As tangible benchmarks for successful completion of the doctoral program, candidates will be
expected to show that they have acquired theskills and expertise to engage as independent
researchers or lead careers in advanced professional occupations.
5. As another important criterion for consideration
upon completion of their program of study,
doctoral candidates will be evaluated to determine whether they have pursued their researchwith firm ethical integrity and a strong sense of
responsibility, and have confirmed that theirresearch contributes to the harmonious coexis-

GRADUATE SCHOOL OF BIOSTUDIES

7

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained to discuss anddebate scientific matters and research outcomes.
Students are also trained to have a broad outlook and flexible thinking in life sciences, and areencouraged to travel to international scientificmeetings.

“Global Frontier in Life Science”
The Graduate Schools of Biostudies and Medi-

October 1st or April 1st in the next year. At the timeof application, prospective students must identify
which laboratory head will direct their doctoral
research. Applicants can apply for only one lab.
Thus, applicants must contact the lab head andf u l l y discuss potential research activities andavailability before filing the application.
Admission examinations for the Doctoral program consist of a documentation screening and anoral examination (interview) to evaluate applicants’knowledge of their field, research competency,
logical thinking skills, and the ability to discuss science in English. Please note that applicants are NOT
required to be physically present in Japan for theexamination.
2) Master’s Program in "Global Frontier in Life Science"
Our entrance examination for the Master’s
program is held in May. The guidelines for admis-

cine offer "Global Frontier in Life Science", a jointsion are posted on our web site (http://www.lif.

educational program for Doctoral and Master’s

kyoto-u.ac.jp/e/). The academic year starts on Oc-

students as part of K.U. PROFILE (Kyoto University

tober 1st or April 1st. Thus, applicants can select thePrograms for Future International Leaders: http://

starting date of either October 1st or April 1st in the

www.opir.kyoto-u.ac.jp/kuprofile/). This program,next year. Applicants to the Master’s program can"Global Frontier in Life Science", is held entirely inapply for up to two labs in which they wish to con-English, including the entrance examinations, lec-

duct research. Thus, applicants should familiarize

tures, experiments, and discussions.

themselves with faculty members’ research inter-

International as well as domestic students are

ests and must contact lab head(s) to fully discuss

welcome. In particular, the program welcomesprospective research activities and availability

those who show a respect for life and a desire to

before filing the application.

create a comprehensive and cutting-edge field

Admission examinations for the Master’s pro-beyond existing disciplinary boundaries in life sci-gram consist of: 1) a documentation screening

ences.

and 2) an oral examination (interview). Please notethat applicants are NOT required to be physically

1) Doctoral Program in "Global Frontier in Life Science"
The two graduate schools hold independent
entrance examinations for this program, and accept up to ten applicants. Our entrance examination for the Doctoral program is held in May.
The guidelines for admission are posted on our
web site (http://www.lif.kyoto-u.ac.jp/e/). The academic year starts on October 1st or April 1st. Thus,
applicants can select the starting date of either

8

GRADUATE SCHOOL OF BIOSTUDIES

present in Japan for the examination.

Lectures held in English for “Global Frontier inLife Science”
1) Doctoral program

bation and an examination upon completion of
the Master’s thesis written under the supervision offaculty.

Offered by the Graduate School of Biostudies
・Frontier in Life Science (1 credit : compulsory)
・Advanced English Discussion and Writing in Life
Science I (1 credit)
・Advanced English Discussion and Writing in Life
Science II (1 credit)
・Overseas Research Project 2 (1 credit)
2) Master’s program
Offered by the Graduate School of Biostudies
・Life Science : From Basics to Applications, from
Molecular Biology to Systems Biology (1 credit :compulsory)
・Beginning Science (1 credit)
・Global Frontier in Life Science A (2 credits)
・Global Frontier in Life Science B (1 credit)
・Advanced Molecular and Cell Biology I (2 credits)
・Advanced Molecular and Cell Biology II (2 credits)
・Cancer Biology (2 credits)・Basic English Discussion in Life Science I (1 credit)・Basic English Discussion in Life Science II (1 credit)
・Cellular & Molecular Neuroscience (1 credit)
・Overseas Research Project 1 (1 credit)

Requirements for completing programs
1) Requirements for completing the Doctoral program・" The Life-Science Special Exercises" (8 credits :compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 1 credit)
For graduation, the student must have enrolled
for at least three years and have completed
at least 10 credits. It is also required to pass theprobation and the examination (thesis defense)
upon completion of a Doctoral thesis written under the supervision of faculty.
2) Requirement for completing the Master’s program
・The Life-Science Experiments and Exercises (20credits : compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 9 credits)
For graduation, the student must have enrolled
for at least two years and have completed atleast 30 credits. It is also required to pass the pro-GRADUATE SCHOOL OF BIOSTUDIES

9

Features of Education
Features of Education
From 2006 to 2007, we conducted the "Biostudies Career-Development Program" supported by
the Ministry of Education, Culture, Sports, Scienceand Technology. From 2008, we have launched

for students. Our school has been emphasizing thedevelopment of communication skills in English. We
encourage and financially support our students togive talks at international conferences abroad. We
also give them advice for their presentation skills.

the "Program for Developing Pharmaceutical
Strategists" as one of the projects of "Reforming3) Workshops organized by students

Programs in Education" at Kyoto University. This

Students in life science fields tend to stay inprogram, in cooperation with the Graduate School

their labs because they are busy working at theof Pharmaceutical Sciences, is aimed to reformbench. However, it is highly important to commu-

the educational system of graduate schools in

nicate with other students studying life science in-our university. Launched in 2011, we are conduct-side and outside of our school during the course of

ing a new program named "Global Frontier in Life

education. We encourage and financially support

Science". In 2012-2013, we were selected as one

the students to organize and conduct workshopsof the schools of the “MEXT Excellent Graduate

by themselves.

School Hub Formation Project ” and supported ourDoctoral students with the subsidy. We are hop-4) Guidance by multiple supervisors

ing that our students will understand the essential

Heretofore, students who were assigned to

aspects of the programs and cooperate with us in

their laboratories studied under the supervision ofachieving their goals.

one faculty member. However, it would be highly
stimulating for the students if they could have

Outline of Reforming Programs in Education
1) Lectures
In our Master’s program, the curriculum is designed to make the students systematically understand life science and its related fields. We offer abroad range of lectures for understanding, revealing, and cultivating the relationship between life
science and our society. In our Doctoral program,advanced courses in life science are offered in addition to the seminars at the lab where each student
belongs. We gear the program to provide the requisite knowledge and experience for the students'
future careers in various fields of Industry, Government, and Academia, at home and internationally.
2) Emphasis on English communication for life science, with support for attendance at international scientific meetings
It is now very important to give seminars in
English, especially scientific presentations at international meetings. Historically, however, the graduate schools in our country scarcely cared about
the development of English communication skills

10

GRADUATE SCHOOL OF BIOSTUDIES

opportunities to discuss their research and othermatters with other faculty members. In our school,
each student is strongly encouraged to consult
with two additional supervisors for his/her current
research and also career objectives. We hope thatthe practice widens their vision on life science andon their future plans.
5) Global Frontier in Life Science (Program conducted in English)
The Ministry of Education, Culture, Sports, Science and Technology launched the "Global 30"
Project for Establishing Core Universities for Internationalization, for the purpose of selecting universities that will function as core schools for receiving
and educating international students. In 2009,
thirteen universities including Kyoto University wereselected. These core universities are playing a major role in dramatically boosting the number of international students educated in Japan as well asJapanese students studying abroad.

Description of Lectures held in
EnglishMaster’s Program

different research fields in life sciences. Lecturers
are mostly young scientists, who have recently

Beginning Science ...........................................................................................................................................
Lecturers: Uemura, Hejna, Usui
Usui）
（Lecturers:

started his or her own researches as lab heads inKyoto University. In addition, the lecturers will pro-This class will cover the history of life science, thevide their experience such as how they have foundbasic phenomena in this field, research meth-enthusiasm in life science research. The discussions

odologies, papers that impressed the lecturers

will be chaired by Dr. Dan Ohtan Wang in all lec-themselves, seminars, and meeting other scientists,tures.

as the beginning of research. Moreover, rules ofresearch and proper analysis of data will be dis-Global Frontier in Life Science B .........................................................................

cussed. Furthermore, to broaden students’ views ofLecturers: Hejna, Chisaka, Toyoshima, Carlton,（Lecturers:

their career path, and their future roles as scientists

Nishihama）
Nishihamain the greater context of our society, we would liketo discuss what Professionalism means, in terms ofcommon sense, regardless of particular career objectives, and how to develop systematic and critical thinking skills.

This class will be conducted exclusively in English. The class will meet on Tuesday mornings from10:30-12:00. The format will be a ~60 min lecture,
followed by a ~30 min. student presentation of apaper or papers covering a subject related to thelecture. Depending on the number of students

Life Science:
From Basics to Applications, from Molecular
Biology to Systems Biology...................................................................................................
Lecturers: Hejna, Nagao, Ohtsuka, Ikura, Kambe,（Lecturers:
Masuda, Carlton, Kumeta）
Kumetaenrolled, the student presentations may be given
by individual students or pairs of students. There isno limit to the class size; in the past, enrollment has
been about 10-15 students, which has been conducive to active discussions.

This class will be conducted entirely in English, andLectures will cover a wide range of topics, fromis designed to acquaint students with a broadplant biology to developmental biology to genetic

range of research areas and methodologies, while

diseases, with attention to methodology and ex-

encouraging students to consider the adaptability

perimental design in student presentations.

or combination of methods in other systems. Topics
will range from a quick review of basic molecu-

Advanced Molecular and Cell BiologyⅠ ..........................

lar biology techniques, to presentations on signal

Lecturers: Chisaka, Kengaku, Yonehara, Harada,（Lecturers:

transduction, transport proteins, applications of

Hejna, Terai, Kumeta）
Kumetafluorescence technology, genome-wide screening, single-molecule imaging, systems biology, regenerative medicine, tissue growth and regulation,
and RNA research. Discussion is also encouraged.
The class is primarily for first-year Master's students,
but 2nd year Master's students may also attend.

This will be a lecture course with a limited numberof students (up to 30). The students will be given
5-8 scientific papers to read. Special emphases will
be on the biologists' way of thinking as well as thebasic concepts on the gene/protein structure andfunction.
1. Logic and basic concepts in biology: How does

Global Frontier in Life Science A........................................................................
Lecturers: Kakizuka, Imamura, Carlton, Kondo
Kondo）（Lecturers:
Lectures in “Global Frontiers in Life Science A.” will
be held in English, and aim to provide basic andfundamental concepts, and knowledge in several

a biologist work and what does a biologistknow?
2. Methods in biology: What kinds of techniquedoes a biologist employ?
3. Specific topics deal with the cell structure and

GRADUATE SCHOOL OF BIOSTUDIES

11

function, the nucleus and central dogma

tional Taiwan Universities through a long-distancelearning system.

Advanced Molecular and Cell BiologyⅡ ..........................

* This lecture will be conducted in English.

Lecturers: Chisaka, Fukuzawa, Fujita, Hejna,（Lecturers:* Lecture hours are from 10:00 to 12:00, Wednesday.

Kitajima, Kusakabe, Ifuku）
Ifuku
This course is an intensive course to introduce theunderlying cell signaling pathways and their me-

Basic English Discussion in Life ScienceⅠ..........................

diators covering mammalian cells, plants and mi-

Lecturer: Hejna
Hejna）（Lecturer:

crobes. The final goal of this course aims to provide

Despite having excellent English reading and writ-

an overall knowledge regarding the diversity anding skills, most students, even native-English speak-significance of cell signaling events in response toers, need to improve their oral English communica-

various stimuli and physiological conditions, andtion skills in order to thrive in the new international

the generality among species. The course will bescientific community. This class is designed to pro-held in combination with related paper discussion.

vide students with ample opportunities to practiceStudents interested in cell and molecular biology

scientific discussions in English, while reviewing ele-

and cell signal transduction are encouraged toments of English grammar and style as they arise.

participate.

An added benefit will be coverage of a diverse
range of current scientific topics; students will be-

Cancer Biology ...........................................................................................................................................................

gin to look critically at scientific data, and how

Lecturers: Yoshimura, Kakizuka, Harada, Kumeta
Kumeta）（Lecturers:

data are presented. The maximum class size will beThis course is an intermediate-to-advanced course

8 students, to create a low-stress environment con-to study a wide variety of recent topics on cancer

ducive to student interactions.

biology. Lectures will be given by researchers working in different fields in Kyoto, Tsukuba, and Na-

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7RWDOFUHGLWV7KHVLVBasic English Discussion in Life ScienceⅡ..........................
Lecturer: Hejna
Hejna）（Lecturer:This class is designed to build upon existing reading and writing skills by developing strengths in oralpresentation and discussion of science in English.
Aimed at Masters students in particular, who may
not yet have extensive research results to present,
the class will consist of shorter (~20-30 min) student
presentations, covering recent science news,

Doctoral Program
Frontier in Life Sicence.........................................................................................................................
Lecturers: Kageyama and others
others）（Lecturers:
Prominent leading scientists from several research
fields of life science, especially those progressing
astonishingly, will provide their research histories
from their backgrounds to future prospects, to encourage young scientists to perform good science.

methods, and technology. Students are expected
to contribute to the class by commenting andraising questions, at the same time strengthening
their ability to look critically at the way science isAdvanced English Discussion andWriting in Life ScienceⅠ .................................................................................................................
Lecturer: Hejna
Hejna）（Lecturer:

presented. If time permits, we may also include

Career advancement depends upon the ability

round-table discussions.

of a researcher not only to read and write English,
but to converse fluently in English. These skills are

Cellular & Molecular Neuroscience.......................................................

crucial for presentations at international meet-

Lecturers: Hejna and Others
Others）（Lecturers:

ings, international collaborations, peer review ofThis is a biennial course and will not be offered in
2017-2018.

manuscripts, and professional networking.

Thiscourse will allow you to further develop your English
language skills by giving oral presentations. In addition, a homework writing excercise will give youpractice in writing a short document, such as an
abstract, a cover letter, or Methods.

Enrollment

will be limited to just 3-4 students, to allow each student two 60-minute oral presentations, and ample
opportunity for informal discussion in a low-stressenvironment.

Advanced English Discussion andWriting in Life ScienceⅡ .................................................................................................................
Lecturer: Hejna
Hejna）（Lecturer:This class continues the development of presentation and discussion skills in English, as in Advanced
English Discussion and Writing in Life Science I, withthe longterm goal of preparing you for an international scientific career. This course will allow you
to further develop your English language skills bygiving oral presentations. Group discussions will befriendly, but objective.

In addition, a homework

writing excercise will give you practice in writing ashort document, such as an abstract, introduction,
specific aims, or methods.

Enrollment will be lim-

ited to just 3-4 students, to allow each student two
60-minute oral presentations (or 1 30-min and 1 60
min talk if 4 students enroll), and ample opportunity
for informal discussion in a low-stress environment.

GRADUATE SCHOOL OF BIOSTUDIES

13

Seminars on Gene Mechanism.............................................................................

Seminars on Mammalian Molecular andCellular Biology ..........................................................................................................................................................

This seminar outlines the principle concepts andThis seminar discusses the biological mechanisms of

related research methods and discusses current

regulation in immunity development of the nervous

topics in Gene Biodynamics research. In addition,system and at the molecular, cellular, and organis-

students report and discuss their own research

mal levels.

■ Division of Integrated Life Science

data to improve their research work and presentation skills.

Seminars on Cell and Developmental Biology .
This seminar discusses the themes of Cell and Developmental Biology, Cell Recognition and Pattern Formation, and Cell Signal Transduction, anddeepens understanding of the related areas. In
addition, students report and discuss their own
research data to improve their research work andpresentation skills.

Seminars on Plant Genes and Totipotency.....................
This seminar discusses the latest developments in
Molecular Biology (especially Genome Biology),
Molecular and Cellular Biology, and introduces
research on Cellular Totipotency at the Molecular,
Cellular, and organismal level. In addition, students
have exercises in problem-solving and discussionsof new research.

Seminars on Applied Molecular Biology................................
This seminar explains and discusses the latest issues
regarding environmental response mechanisms in
mammals or microorganisms, and the future direction of research applications.

Seminars on Molecular Mechanisms of
Responses to Environmental Stimuli........................................................
This seminar covers the latest issues regarding various internal and external biological responses, andareas in related fields with different points of view.

Seminars on Molecular and Developmental
Biology .....................................................................................................................................................................................................
This seminar discusses the solved and unsolved
problems about the dynamic behaviors of DNA,
proteins and cellular structures in live cells in orderto deepen the students’ understanding. Students
report their research progress and adjust the direction through discussion.

14

GRADUATE SCHOOL OF BIOSTUDIES

■ Division of Systemic Life Science

immunological disorders, genetic diseases, andSeminars on Molecular and Systems Biology ........

biological mechanisms of adult diseases.

This seminar focuses on how to bridge the gap
between individual molecular activities and patho-

Seminars on Functional Biology...........................................................................

physiological regulation of the dynamic life systems

This seminar explains and discusses the latest in-

by using advanced single-molecule imaging andformation about molecular mechanisms of the

FRET technologies.

homeostatic regulation in physiological and pathological conditions.

Seminars on Animal Development andPhysiology ....................................................................................................................................................................................
This seminar discusses the latest information regard-

Seminars for Department of Biology Educationand Heredity ......................................................................................................................................................................

ing genetic regulation, from a broad perspective.

We will investigate the mechanisms eukaryotic cells

In addition, we cover explains illnesses such asuse to maintain their genomes and to accurately

cancer caused by abnormal cell differentiationtransmit recombined chromosomes to the next

and proliferation, immunological disorders, genetic

generation in the process of sexual reproduction.

disorders, and lifestyle related diseases, outlining

Discussions will focus on developing critical thinking

the research methods used to investigate the mo-skills necessary for science throug presentation andlecular biology and pathogenesis of adult diseases.

critique of research results.

Seminars on Molecular Mechanisms of Signal
Transductions......................................................................................................................................................................

Seminars on Mammalian Regulatory Network ..

Cancer, autoimmune diseases, and life-style relat-

biological cellular control, genetic response, carci-

ed diseases can be caused by genetic abnormali-

nogenesis caused by viruses, the principle of immu-

ties and aberrant response mechanisms. This semi-

nological response; the structure and regulation of

nar explains and discusses dysfunctional biologicalgenetic information responsible for such systemic

mechanisms of cell proliferation, self- / non self-

functions are being analyzed using model animals.

This seminar discusses the mechanisms of systemic

immunological identification mechanisms, cancer,

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15

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism❖ How the brain and the body work・Department of Gene Mechanisms❖ How the body is built

log・Department of Molecular and Cellular Biology❖ How the human diseases occur
・Department of Molecular and System Biologyo❖ How multicellular organisms work
olo・Department of Cell and Developmental Biologyy・Department of Plant Gene and Totipotency
enta・Department of Molecular and Developmental
Biologyth❖ How organisms interact withenvironments

・Department of Animal Development andPhysiology
・Department of Signal Transductions
・Department of Functional Biology
ory NetNetwork・Department of Mammalian Regulatory

ethics❖ Communications・Bioethics
tion and Heredity
・Department of Biology Educationy・Department of Applied Molecular Biology
ironmenta
・Department of Responses to Environmental
Signals and Stresses

Living organisms
ms

Human bbeingsGenes and cells

16Outline and Composition of Departments

DIVISION OF INTEGRATED LIFE SCIENCEThis division consists of 18 laboratories including six cooperative laboratories from Radiation Biology Center, Institute for Frontier Life and Medical Sciences, and Institute of Integrated Cell-Material Sciences (iCeMS).
40 graduate students are accepted in the Master’s Program annually,and 19 in the Doctoral Program. In this division, education and research
are focused on the elucidation of basic mechanisms regulating the chromosome transmission, chromosome replication, RNA architecture, cell
cycle, cellular transport, cell polarity, signal transduction, growth and development, developmental plasticity, bioconversion, and environmental
adaptation. Experimental approaches are taken with microorganisms,
plants, and animals. We pursue education and research to elucidate themolecular aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanisms

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Associate Professor

NAKASEKO, Yukinobu■ Main theme

SHIRAISHI, Hideaki■ Main theme

We are focusing on analyzing the genes involved

We are interested in the mechanism of growth,

in regulation of chromosome function. Especially,

development and evolution of photosynthetic

the genes essential for mitosis have been studied.

microorganisms and currently focusing on the study

Fission yeast Schizosaccharomyces pombe is usedof the edible cyanobacterium Arthrospira (Spirulina)

as a model system. This yeast has all basic featuresplatensis. A. platensis is a filamentous alkalophilic

essential for eukaryotic cell division. Many genes havecyanobacterium that has been traditionally consumed

been identified which regulate the cell cycle of thisas food by people living along the shores of alkaline

yeast. Also, their functions as well as their primarylakes in several regions in the world. Because it can be

structure have been shown to be conserved amongcultured under alkaline conditions where growth of

all eukaryotic cells. We are trying to characterize theseother microalgae is suppressed, it can be produced

genes and their functions by genetical approach.

in mass cultures outdoors as an almost single algal

Elucidation of whole functional network of thesestrain. Because of its easiness of mass culture, it isgenes is one of a goal in our research.

commercially produced in many subtropical areasin the world and consumed worldwide as food, foodadditives, and feed for animals and fishes. We are
currently focusing on developing tools for molecular
genetic studies of this cyanobacterium.

http://kuchem.kyoto-u.ac.jp/seika/

18

DIVISION OF INTEGRATED LIFE SCIENCEDepartment of Celland Developmental Biology

Laboratory of Cell Cycle Regulation

Laboratory of Cell Recognition and
Pattern Formation■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

ISHIKAWA, Fuyuki
MIYOSHI, Tomoichiro
SADAIE, Mahito■ Main theme
Stable maintenance of genetic information isessential for cell viability. Genetic instability, a conditionin which the genome is not properly maintained, causes
numerous pathologies including cancer and aging.
Telomeres, the ends of chromosomes, play a pivotal
role in this process. We are interested in how telomeresprotect genetic information from intrinsic and extrinsic
insults. Aging can be defined as the accumulationof damaged cells caused by various stresses. Stress isgenerally considered to be non-adaptive. However,
low-dose stress can act in an adaptive role by fosteringcell resistance to prospective lethal stresses. This process
is termed acquired tolerance (or hormesis) and its
molecular mechanisms remain largely unknown. We aretrying to understand how acquired tolerance is induced
molecularly. Arguably, cancer cells in vivo acquire
stress resistance through experiencing ever-lasting
environmental changes. As such, inhibiting the acquired
tolerance in cancer cells may lead to fragility of cancers
to various stresses, including iatrogenic ones.
•Molecular understanding of how telomeresprotect DNA ends in fission yeast and mammals.
•Functional roles of acquired tolerance in various
physiological and pathological conditions.
•Mechanism of retrotransposition and its impact on
genomic instability in the mammalian genome.
•Development of therapeutic strategies forcancer by elucidating the mechanisms of cellularsenescence.
•Mechanism of genomic instability induced bychromosome end-to-end fusions.
In general, cells
exposed to lethal stress
Cell Deathundergo cell death
Lethal Stress(A). However, cells pre(B)conditioned with mild
stress can become
Acquiredresistant to subsequent
Tolerance
lethal stresses (B).
Survival
Mild Stress
Lethal StressThis process is called
Environmental Fluctuationacquired tolerance
or hormesis: an adaptive behavior that is crucial for survival
in an ever-changing environment. In vivo, cancer cells canexperience environmental changes such as hypoxia andiatrogenic stress. This is in contrast to normal cells that live ina stable niche given by the tissue. It is possible that cancer
cells are pre-conditioned by the environmental changes toprepare for the prospective lethal stress. Therefore, inhibitionof this acquired tolerance may make cancer cells sensitive toanti-cancer therapeutics.
http://www.fish.lif.kyoto-u.ac.jp/

UEMURA, Tadashi
USUI, Tadao
HATTORI, Yukako■ Main theme
Diet is a critical environmental deter minantthat affects life-history traits. We are studying
dietary responses that govern animal growth. We
are also dissecting neuronal circuits that evoke
selective behaviors in response to sensory stimuli.
Furthermore, we are finding the universal rule(s) inthe morphogenetic system of multicellular organs
consisting of complicated levels of hierarchy, fromgenes, cells to tissues.

(A)

http://www.cellpattern.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

19

Division of Integrated
Life Science
Department of Plant Gene and Totipotency

Laboratory of Signal Transduction

Laboratory of Plant Molecular Biology■ Professor■ Lecturer■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

NISHIDA, Eisuke
KUSAKABE, Morioh
MIYATA, Yoshihiko■ Main theme

KOHCHI, Takayuki
NISHIHAMA, Ryuichi
YAMAOKA, Shohei■ Main theme

We are interested in identifying and elucidating

Research in this laboratory focuses on themolecular mechanisms that regulate cell

adaptive regulation of growth and development toproliferation, cell differentiation, cell cycle, aging

environmental conditions and its evolution by using

and developmental processes. The current topics

model photosynthetic organisms. Especially with theinclude 1) regulatory mechanisms and functions ofliverwort Marchantia polymorpha, which is a basal

the MAP kinase cascade pathways, 2) identification

land plant ideal for comparative evolutionary studies

of novel signal transduction mechanisms, 3) molecularand amenable to molecular genetic manipulation, we

mechanisms for life span regulation, 4) roles of protein

aim to elucidate principles and ancestral molecularkinases in cell cycle progression and regulation, 5)

mechanisms of photomorphogenesis, growth phasegrowth factor signaling mechanisms in developmental

transition, phytohormone signaling, meristem function,

processes, 6) regulatory mechanisms for mammaliancell division, and cell differentiation in land plants.

circadian clock.

http://www.signal.lif.kyoto-u.ac.jp/

20

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.plantmb.lif.kyoto-u.ac.jp/

Department of Applied Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency

Laboratory of Biosignals and Response■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

NAGAO, Masaya
KAMBE, Taiho
NISHINO, Katsutoshi■ Main theme

Molecular and cellular biological studies on

Bio-prospecting, a research strategy searching for

totipotency in plant cells have been carried out in thiscompounds that possess beneficial activity for healthlaboratory using in vitro cultured cells and transgenic

from natural sources, is one of the projects in thisplants. Especially, cell/organ differentiation fromlaboratory. Especially, compounds that are useful for

undifferentiated cells, functional differentiations,

treatment of lifestyle-related diseases and cancer are

e.g. secondary metabolite production, such as

the main targets of our bio-prospecting.

biosynthesis of isoquinoline alkaloids, oxygen evolving

We are also studying how organisms perceive

complex in photosystem II, cyclic electron transfer

environmental signals and transduce these signals intoand gene regulation in chloroplast, have beenchanges in gene expression, focusing mainly on theinvestigated to understand the totipotent functions inmolecular and cellular basis of zinc metabolism (suchplant cells. Development of novel genetic engineering

as uptake, storage, delivery, and maintenance oftechniques such as genome editing, metabolic

metal concentration in cells) in mammal.

engineering and synthetic biology of secondary
metabolism for industrial application have been also
investigated.

http://www.callus.lif.kyoto-u.ac.jp/

Stimulation of lipid accumulation by plant extracts

http://www.seitaijoho.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

21

Division of Integrated
Life Science

Laboratory of Applied Molecular Microbiology

Laboratory of Molecular Biology ofBioresponse■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

FUKUZAWA, Hideya
YAMANO, Takashi
KAJIKAWA, Masataka■ Main theme

KATAYAMA, Takane
MASUDA, Seiji
KATOH, Toshihiko■ Main theme

We are focusing on the molecular bases of biological

The aim of our laboratory is to understand thefunctions of microalgae contributing to production of food,

fundamental life processes of microbes and human,

biofuel and industrial materials, and also to environmental

and to develop food- and health-oriented application

remediation by photosynthesis. Especially we employ

research. The research activities mainly include (1)a green alga, Chlamydomonas reinhardtii, as a model

elucidation of the molecular mechanism underlying

eukaryotic photosynthetic microorganism using its genomic

symbiosis and co-evolution between gut microbes

information, mutants, and molecular/biochemicaland host, and (2) elucidation of the mechanism oftechniques.

mRNA processing, export and quality control in the

The current projects are

nucleus in human and its industrial applications.

(1) Molecular characterization of the carbon-concentrating(1) Recent studies have shown that the consortium

mechanism supporting photosynthetic carbon fixation,of gut microbes exerts a considerable influence on

biofuel production, and cell proliferation,

host health. Most researchers approach this topic from

(2) Elucidation of regulatory systems controlling“host” side using a mouse model, but we believe thatphotosynthesis and carbon metabolisms by sensing

approaches from “microbe” side are equally needed

environmental factors including changes of levels in CO2

to understand the symbiosis between them. To thisconcentration, light and nutrient starvation.

end, we are genetically and enzymatically analyzing(3) Metabolic engineering for production of industrial

unique metabolic pathways in gut microbes, which

important fatty acids, glycerolipids and carbohydrates.

should uncover the cross-kingdom communications(4) Molecular control and signaling of sexual reproduction
by nutrient starvation.

between bacteria and host in intestine.
(2) The main projects are (i) the role of TREX and(5) Identification of factors essential for intracellular signal

AREX, which couple transcription and export oftransduction such as calcium and DYRK family ofmRNA, (ii) the molecular mechanism of RNA quality

protein kinases supporting cell survival.

control in the nucleus, (iii) cell engineering for theprotein production using mRNA export mechanism inmammalian cells to apply to industrial applicationsand (iv) identifying the active compounds which
inhibit the mRNA matabolism to apply to medical
care.

http://www.molecule.lif.kyoto-u.ac.jp/

22

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.bunshioutou.lif.kyoto-u.ac.jp/

Department of Responses to Environmental Signals and Stresses

Laboratory of Plant Developmental Biology

Laboratory of Plasma Membrane andNuclear Signaling■ Professor■ Associate Professor■ Associate Professor■ Assistant Professor

ARAKI, Takashi
ENDO, Motomu■ Main theme

YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

We are interested in molecular mechanisms

Our laboratory studies dynamic properties ofunderlying plant’s responses to environment. Plants

proteins and large protein complexes in cellular

have evolved plastic developmental programs

environments by using a variety of techniqueswith both genetic and epigenetic basis to adapt

in biochemistry, molecular biology and cellular

their sessile mode of life to changing environment.

biology, in combination with nano-technology andUsing an angiosperm, Arabidopsis thaliana and acomputational simulation. Specific research topics

liverwort, Marchantia polymorpha as model systems,

include:we have been investigating (1) regulation of growth(1) U n d e r s t a n d i n g m o l e c u l a r m e c h a n i s m a n dphase transition (especially, flowering) in response

biophysical background of mitotic chromosome

to environmental signals, (2) long-distance systemic

condensation

signaling in the control of development, (3) role(2) S i n g l e - m o l e c u l e i m a g i n g o f h i g h e r - o r d e rof circadian clock in cell differentiation, (4) sexualarchitectures of DNA, RNA and various

reproduction processes, and (5) origin and evolutionof regulatory systems for plastic development.

nucleoprotein complexes(3) N o n - i n v a s i v e i m a g i n g o f m e m b r a n e a n dcytoskeletal dynamics by fast-scanning atomic
force microscopy(4) Understanding physical and chemical mechanismsof subunit assembly and disassembly of nuclear
pore complex(5) Structural dynamics of flexible and repetitive
proteins in intracellular environments and molecular
crowding

http://www.chrom.lif.kyoto-u.ac.jp/english/
http://www.plantdevbio.lif.kyoto-u.ac.jp/

index.html

DIVISION OF INTEGRATED LIFE SCIENCE

23

Division of Integrated
Life Science
Department of Molecular and Developmental Biology

Laboratory of Genome MaintenanceLaboratory of Developmental
Neurobiology■ Professor■ Lecturer■ Professor

MATSUMOTO, Tomohiro
FURUYA, Kanji■ Main theme

KENGAKU, Mineko■ Main theme

The spindle checkpoint, our major research

Neurons in the mammalian brain are orderly

subject, is a surveillance mechanism to regulatearranged in cortices and nuclei for integration into

cellular apparatus for compliance with this rule. It is a

specific neural circuits. During development, neurons

unique negative feedback that converts/amplifies a

directionally migrate from the birthplace to their

physical signal sensed by kinetochores (attachment ofdestination within the cortex, and then arborize

the spindle and/or tension) and regulates the timing

well-patterned dendrites and axons to contactof the sister chromatid separation. Mad2, a signal

with their specific synaptic counterparts. The major

carrier of this feedback, plays a vital role in the spindle

goal of our research is to clarity the mechanisms ofcheckpoint. It is specifically localized at unattachedcortical lamination and functional wiring of neurons

kinetochores that are the origin of the checkpointin the brain. We seek to identify the molecularsignal. Mad2 targets CDC20 and inhibits its activity tosignals regulating neuronal migration and dendrite

promote sister chromatid separation. We study Mad2,

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n ga central player of the spindle checkpoint, to reveal

techniques for real-time observation of molecular andmechanisms, which regulate the activity of Mad2.

cellular dynamics of neuronal migration and dendrite
patterning to discover novel phenomena and rules inneuronal motility in the developing brain.

Molecular Layer

Purkinje Cell Layer
Granule Cell Layer
White Matter

Granule Cell

Purkinje Cell
Cerebellar nuclei

http://www.rbc.kyoto-u.ac.jp/radiation_system/

24

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.kengaku.icems.kyoto-u.ac.jp/

Department of Molecular and Cellular Biology

Laboratory of Molecular and Cellular
Immunology

Laboratory of Developmental Dynamics■ Professor■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

FUJITA, Takashi
KATO, Hiroki■ Main theme

KAGEYAMA, Ryoichiro
OHTSUKA, Toshiyuki
KOBAYASHI, Taeko■ Main theme

Virus infections, such as influenza A epidemic, Ebola

We a n a l y z e t h e m o l e c u l a r m e c h a n i s m o fhemorrhagic fever, Middle East respiratory syndrom, Zika

embryonic development by using the mostvirus infection are important diseases and outbreaks

advanced methods such as imaging, optogenetics

of newly emerging viruses are serious problems forand transgenic mouse technologies. We evaluate

modern society. Higher animals, including humans, aremathematical modeling by using transgenic mice andgenetically equipped with mechanisms, collectively

seek to understand the principles of developmental

known as innate immunity, to counteract viral infections.

dynamics. We found that oscillatory gene expression is

During the course of replication, many viruses generate

important for many developmental processes such as

double-stranded (ds)RNA, which is virtually absent inbrain morphogenesis and somite formation.

normal cells and likely serves as a "foreign molecule"in cells. An RNA helicase, RIG-I, functions as a sensor
for viral dsRNA. RIG-I is composed of three domains : a
Caspase recruitment domain (CARD), a DExD/H helicase
domain, and a C-terminal domain (CTD)(Figure). CTDsenses viral dsRNA produced in the cytoplasm, leading
to a conformational change. This conformationalchange releases CARD, which signals to downstream,
resulting in the activation of genes including those fortype I interferon and other cytokines. The purpose of our
project is to clarify the molecular mechanism underlying
the antiviral innate immunity regulated by RIG-I, and todevelop new diagnostic and therapeutic means for viral
infections.

http://www.virus.kyoto-u.ac.jp/Lab/

http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden2012/English/index.html

Kageyama/index_English.html

DIVISION OF INTEGRATED LIFE SCIENCE

25

Division of Integrated
Life Science

Laboratory of Ultrastructural Virology■ Professor■ Assistant Professor

NODA, Takeshi
NAKANO, Masahiro■ Main theme
Virus infections are accompanied by numerous
ultrastructural changes in viral and cellularcomponents. Our laboratory has been investigating
the replication mechanism of influenza and Ebola
viruses from the ultrastructural point of view, by using
different microscopic methods such as electron
microscopy and high-speed atomic force microscopy.
Visualization and characterization of the virus life
cycle at the nano-mesoscopic level give us uniqueknowledge and novel paradigms, which will advanceour understanding of molecular basis of the replication
mechanism.

Scanning electron micrograph of Ebola viruses budding fromcell surface.

26

DIVISION OF INTEGRATED LIFE SCIENCEDIVISION OF SYSTE
SYSTEMIC LIFE SCIENCEThis division consists of 20 laboratories including eight cooperativelaboratories from Institute for Frontier Life and Medical Sciences, Institutefor Advancement of Clinical and Translational Science, Radiation Biology
Center and RIKEN Center for Development Biology. 35 graduate students
are accepted in the Master’s Program annually, and 14 in the Doctoral
Program. In this division, education and research are focused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental approaches are taken with viruses,
microorganisms, cultured cells and animals. We pursue
ue education andresearch to elucidate the molecular aspects of Systemicc Life Science.

Division of SystemicLife Science
Department of Molecular and System Biology

Laboratory of Single-Molecule Cell Biology

Laboratory of Bioimaging andCell Signaling■ Professor■ Assistant Professor■ Assistant Professor

MATSUDA, Michiyuki■ Professor■ Associate Professor TERAI, Kenta■ Associate Professor (Excellent Young Researcher)
IMAYOSHI, Itaru
IMAJO, Masamichi■ Assistant Professor

WATANABE, Naoki
YAMASHIRO, Sawako
MIZUNO, Hiroaki■ Main theme
Our laboratory aims at bridging the gap between
molecular activities and cell physiology in life systems.

■ Main theme

We are trying to visualize signal transduction and

We are visualizing the growth signal transduction

cell structure remodeling processes directly in living

cascades in living cells by using biosensors based oncells by fluorescence single-molecule microscopy.

the principle of Foerster resonance energy transfer

We have also recently invented new super-resolution(FRET). These FRET videos are used to characterize

microscopy called IRIS, which achieves ultra-

the property of each signaling molecule. We are alsohigh density labeling of multiple targets in a single

developing transgenic mice expressing FRET biosensors

specimen. By direct viewing using these advanced

to observe the signaling status in living mice with

optical techniques, our laboratory elucidates thetwo-photon excitation microscopes. We also study

mechanism and the dynamics of pathophysiologicaldevelopment and plasticity of nervous system by using

cell signaling.

in vivo imaging of mouse brain.

http://www.pharm2.med.kyoto-u.ac.jp/

http://www.fret.lif.kyoto-u.ac.jp/mi.htm

28

DIVISION OF SYSTEMIC LIFE SCIENCEDepartment of Animal Development and Physiology

Laboratory of Molecular andCellular Biology

Laboratory of Immunobiology■ Professor■ Associate Professor■ Associate Professor

YONEHARA, Shin
SAKAMAKI, Kazuhiro■ Main theme

TAKAHARA, Kazuhiko■ Main theme

Apoptosis, or programmed cell death, plays an

Our interest is the induction and control ofimportant role in many biological processes, including

i m m u n i t y . We f o c u s o n d e n d r i t i c c e l l s ( D C s ) ,embryogenesis, development of immune system,

which are a primary antigen-presenting cell in themaintenance of tissue homeostasis, and elimination

immune system. Our current major topics includeof virus-infected and tumor cells. We found cell

the control of DC functions using several types of

surface Fas antigen (Fas), which can directly mediate

glycolipids, resulting in both immune activation andapoptosis-inducing signals into cells by stimulation with

suppression. We are also interested in functions ofagonistic anti-Fas mAbs or Fas ligand (Yonehara S, etlectin molecules expressed on DCs/macrophages thatal., 1989; Itoh N, et al., 1991). Our main research project

recognize polysaccharides on pathogenic agents.

is to understand the intracellular signal transduction

The study includes analyses of interaction between

mechanism of cell death including apoptosis andpolysaccharides and lectins, and subsequentcaspase-independent novel types of cell death,cellular and systemic responses in co-operation withand the biological significance/physiological role of

TLR signaling. In this study, we found that certain

cell death and cell death-regulating molecules. In

lectin-polysaccharide interaction induced immune

conjunction with these studies, we have been trying tosuppressive environment, ameliorating excessive andidentify other cell death-related molecules that playlethal inflammation. By these studies, we would like toa key role in embryogenesis, tumorigenesis or immune

develop new methods to control immune system.

system. Investigations of molecular mechanisms andMouse lectins expressed on DCs/macrophages

physiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

http://www.fas.lif.kyoto-u.ac.jp/

http://zoo.zool.kyoto-u.ac.jp/imm/

DIVISION OF SYSTEMIC LIFE SCIENCE

29

Division of SystemicLife Science

Laboratory of Molecular Cell Biology andDevelopment（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Visiting Professor（Kitajima Laboratory）■ Visiting Associate Professor■ Main theme■ Main theme

We seek to explore the molecular mechanisms
underlying the organization of cells into highly orderedstructures in the developing brain. The vertebrate brain
comprises a considerably larger number of neurons
arranged in a vastly complex functional network,
which develops from a single layer of epithelial
cells that function as neural stem cells. Those cells
initially proliferate to expand their population, andsubsequently shift their division mode from symmetricto asymmetric cell divisions to generate stem cells andneurons. Thus, the control of stem cell and their divisionmodes are critical to form the brain. We recently
found a new division mode, which likely contributes
to the expansion of neural stem cell pool that had led
to the big ban in the brain size and complexity during
mammalian development.
We use Drosophila, mice and ferrets as model
systems to understand principles for the brainorganization such as;
1. H o w i s t h e t i m i n g o f t h e p r o l i f e r a t i v e t oneurogenic transition determined?
2. How do neural stem cells undergo asymmetric
divisions?
3. How does cell polarity contribute to asymmetriccell division?
4. How is the brain architecture dictated by neuralstem cells?
5. How do such complex brains as those of
primates and ferrets develop?

KITAJIMA, Tomoya

In order to maintain genetic information acrossgenerations, cells must segregate chromosomes
equally to daughter cells during mitosis. Meiotic
divisions of the mammalian oocyte, however, are
known to exhibit a higher frequency of errors inchromosomal segregation than in other cell types.
Moreover, oocyte chromosomes behave in ways
distinct from those in other cells, and these uniquedynamics may provide insights into novel mechanisms
for chromosome segregation. Taking advantage of
our established live imaging technologies, we seek
to conduct detailed and comprehensive analysesof the chromosome dynamics and the molecularmachinery that underlies chromosome segregation
during mammalian oocyte meiosis. We also seek to
identify the causes behind age-related increases inchromosome segregation errors during oocyte meiosis.

Prometaphase belt of chromosomes

http://www.cdb.riken.jp/en/research/laboratory/matsuzaki.html

30

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.cdb.riken.jp/lcs/index_en.html

（Takasato Laboratory）■ Visiting Associate Professor

TAKASATO, Minoru■ Main theme
Due to the continuous rise in the incidence ofend-stage renal disease around the world, there isan urgent demand for regenerative strategies tocompensate for the loss of renal function in thesepatients. In our previous study, we developed aprotocol by which human pluripotent stem cells canbe differentiated into the intermediate mesoderm thatcan self-organize into kidney organoids. While thesekidney organoids comprise all anticipated renal tissues,
including nephrons, collecting duct, blood vessels
and renal interstitium, they are still far from the realhuman kidney in terms of their size, tissue complexity,
maturity and functionality. By precisely recapitulating
the developmental processes of the human kidneyin directed differentiation of human pluripotent stem
cells, we are trying to achieve the ultimate goalof generating a three-dimensional kidney that isfunctional and can be transplanted into patients. We
appreciate knowledge from basic developmental
biology that is essential for such regenerative studies;
therefore, we are also highly interested in studies ofhuman embryology. Particularly, we are focusing on
uncovering the developmental mechanisms of thehuman mesoderm and kidney.

A kidney organoid generated from human pluripotent stem cells

http://www.cdb.riken.jp/research/laboratory/takasato.html

DIVISION OF SYSTEMIC LIFE SCIENCE

31

Division of SystemicLife Science
Department of Signal Transductions

Laboratory of Molecular Neurobiology

Laboratory of Genetics■ Professor■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

NEGISHI, Manabu
KATOH, Hironori■ Main theme
Outline of Teaching Activities

IGAKI, Tatsushi
OHSAWA, Shizue
ENOMOTO, Masato■ Main theme
Our research focuses on the molecular basis of

The laboratory provides seminars which review andcell-cell communication that governs tissue growth,

discuss recent progress in molecular mechanisms of

homeostasis, and cancer. We take advantage of theneuronal functions

powerful genetics of Drosophila.

Outline of Research Activities
The main themes of research in this laboratory■ Research subjects:
1. Mechanism of cell competition

are the molecular mechanisms underlying neuronal

2. Genetic basis of tissue growth regulation

network formation and neuronal signal transductions.

3. Molecular basis of tumor progression and

1. Neuronal functions and signal transductions of
GTP-binding proteins
2. Molecular mechanisms for axon guidance

metastasis
4. Logic for morphogenesis from folded epithelial
sheets3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formation

Left:Polarity-deficient cells (green; losers) are eliminated from
epithelium by wild-type cells (magenta; winners) through cellcompetition.
Right:Malignant tumor cells (magenta) are invading andmetastasizing from the eye disc to the brain (blue) in Drosophila
larva.

http://www.negishi.lif.kyoto-u.ac.jp/e/Top.html

32

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/genetics/

Department of Functional Biology

Laboratory of Functional Biology■ Professor■ Associate Professor■ Assistant Professor

KAKIZUKA, Akira
IMAMURA, Hiromi
SASAOKA, Norio■ Main theme
Using animal models of human diseases, such asneurodegenerations, cancers, and obesity-relateddiseases, and using metabolite imaging techniques,
we aim to elucidate molecular bases of such diseases
and develop new strategies to cure or prevent them.
One of the main features of life science researchin the coming years will be that the results obtained
from fundamental research should ideally bedirectly connected to the good of society. From thisstandpoint, in addition to handling topics with highscientific significance, we aim to contribute to thedevelopment of treatments for neurodegenerative
diseases, cancers, and obesity-related diseases fromour research results.
We hold the same view on scientific education,and through training individuals to communicate theirideas logically yet effectively, as well as by nurturing
their creativity, in addition to strengthening theirpractical research skills, we aim to cultivate opinion
leaders standing at the core of life science research inthe 21st century.

http://www.funcbiol.lif.kyoto-u.ac.jp/

DIVISION OF SYSTEMIC LIFE SCIENCE

33

Division of SystemicLife Science
Department of Biology Education and Heredity

Laboratory of Science Communication

Laboratory of Bioeducation■ Professor■ Professor

HEJNA, James Alan

■ Main theme
Our laboratory engages in the development
and implementation of new approaches to the

CHISAKA,Osamu■ Main theme
Our laboratory has been trying to improve study
materials on biology.

inter nationalization of science education andcommunication, based on principles of active
learning. The particular challenges we are addressing
often involve overcoming the differences in culture
and pedagogical traditions between Japaneseand Western societies. Our efforts are chiefly inthe educational arena, aimed at training the next
generation of scientists to communicate theirknowledge and expertise not only to the international
scientific community but locally to the citizens who
ultimately support basic research. Our activities entail
the following:
1. Increasing the exposure of Japanese students toforeign peers. We are forging new partnerships
with foreign universities to foster joint courses,
using live Internet connections, with active
student participation in English.
2. Establishing partnerships with foreign universities
to encourage short-term reciprocal exchangesof graduate students for collaborative research.
3. Expanding the opportunities for students topresent their research in English to a broad
audience.

34

DIVISION OF SYSTEMIC LIFE SCIENCE

1. Introduction of moder n topics into study
materials on biology
2. Introduction of active learning methods into
biology lectures in English
3. Exploitation of new biology lab course protocols
and materials

Laboratory of Chromosome Function andInheritance■ Associate Professor

Laboratory of Science Communication
and Bioethics

CARLTON, Peter■ Main theme■ Main theme

We aim to understand the mechanisms that

In our laboratory, we aim to identify essential issues

enable the transmission and maintenance of thein the interface between biostudies and the society,genome across cell divisions. We combine super-

and to propose possible actions or solutions.

resolution microscopy and other advanced imaging
techniques with molecular genetics to study
chromosome dynamics in meiosis, as well as the rolesof epigenetic modification of chromatin during DNA
repair.
Our current resrarch focuses on the following
areas:

Currently, we are focusing on the following threeareas.
1.Theoretical and practical analysis of science
communication.
In addition to organizing practical activities suchas "Genome Square", a public event (http://hiroba.
genome-sci.jp/ in Japanese language only), we•Functional analysis of epigenetic modifications inanalyze the effects and significance of science

DNA repair

communication. This includes the communication•Understanding mechanisms of chromosome

between scientists and the general public, and thatdynamics and regulation during meiosis

among scientists and scientific communities.

•Functional analysis of epigenetic modifications
during differentiation of mammalian cells•Analysis of chromosome structures using superresolution microscopy

2. Analysis of bioethical issues in biostudies.
We study ethical, legal and social implications ofbiostudies such as human genome research andhuman stem cell research.
3. Analysis of modern history of biostudies.
We analyze the development and changes ofbiostudies in the last 20 to 30 years through literature
surveys and interviews with scientists.

www.carltonlab.org

DIVISION OF SYSTEMIC LIFE SCIENCE

35

Division of SystemicLife Science
Department of Mammalian Regulatory Network

Laboratory of Cell Regulation and
Molecular Network

Laboratory of RNA Viruses■ Professor■ Assistant Professor■ Professor■ Associate Professor

SUGITA, Masahiko
MORITA, Daisuke■ Main theme

TOMONAGA, Keizo
HIJIKATA, Makoto■ Main theme

Full attention of this laboratory has been

The researches carried out in our laboratory are

directed to previously unappreciated aspects offocused on several RNA viruses, including bornavirus,

the acquired immunity that we call “lipid immunity”.

and hepatitis C virus. All our projects aim to understand

Unlike conventional MHC molecules that present

the fundamental mechanisms of the replication andprotein-derived peptide antigens, molecules of thepathogenesis of these viruses. We are investigating

human group 1 CD1 family (CD1a, CD1b, CD1c)

the replication and persistent mechanism of themediate presentation of “lipid” antigens to specific T

bornavirus in the cell nucleus. The understanding thelymphocytes. In addition, we have recently identified

biological significance of the endogenous elementa novel lineage of antigen-presenting molecules,of bornaviruses in mammalian genomes is one of thetermed LP1, capable of mediating presentation of

main focuses of bornavirus researches. We also aim“lipopeptide” antigens. By taking cell biological,

to develop a novel RNA virus vector using bornavirus,

immunological and lipid chemical approaches, thiswhich can express stably functional small RNAs.

laboratory wishes to establish a molecular and cellular

The understanding of the molecular mechanism ofbasis for lipid immunity and determine how CD1 andtumorigenesis caused by hepatitis viruses is also theLP1 have been evolved to function critically in hostmain purpose of our laboratory.

defense. An important extension of this research is achallenge for developing a new type of lipid-based
vaccines against cancer and microbial infection.

http://www.virus.kyoto-u.ac.jp/Lab/
SugitaLab.html

36

DIVISION OF SYSTEMIC LIFE SCIENCE

https://t.rnavirus.virus.kyoto-u.ac.jp/

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Assistant Professor■ Assistant Professor■ Professor

TOYOSHIMA, Fumiko
ODA, Yukako
MATSUMURA, Shigeru■ Main theme

SHIMIZU, Akira■ Main theme

How adult tissue stem cells adapt to physiological

Major goal of research in this laboratory is tochanges is a fundamental question in stem cellunderstand molecular and cellular mechanisms

biology. Stem cell self-renewal and differentiation via

underlying highly systemic functions of living things,

symmetric/asymmetric cell division in response to asuch as immune and neural systems. For this purpose,

physiological alteration leads to changes in organ size

structure and regulation of genetic informationand tissue homeostasis. Our group seeks to explore

responsible for such systemic functions are being

the molecular mechanisms underlying the oriented

analyzed using model animals, for example,

stem cell division, stem cell activation, and cell fatetransgenic or gene disrupted mice. Our research isdetermination. We want to know how tissue stem

focused on the following subjects:

cells are activated in response to the physiological

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n dchanges of the body, such as pregnancy, and try

regulation of chromatin modification, geneto apply the mechanisms to tissue engineering andexpression, gene rearrangements and RNA

regenerative medicine.

processing during lymphocyte differentiation.

Our research is focused on the following subjects:

2. Making and characterization of model mice

1, Molecular mechanisms of symmetric andof immunodeficiency or autoimmune byasymmetric cell division.

introduction of, or targeted disruption of

2, E p i d e r m a l s t e m c e l l r e g u l a t i o n i n s k i nhomeostasis.

interleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for

3, Maternal stem cell regulation during pregnancy.

lymphocyte mobility and formation of immunomicroenvironment during development andimmune reaction.

dyneinVirus, bacteria,
UV etc..

BarrierSymmetric

Asymmetriccell divisioncell division

TissueStratification

expansion

Homeostasis

Cell cortex

Cell cortex

Epidermis

Basement membrane
DermisHypodermis

TXLHVFHQWVWHPFHOODFWLYDWHGVWHPFHOOSURJHQLWRUFHOOV

http://www.virus.kyoto-u.ac.jp/Lab/
toyoshima.html

DIVISION OF SYSTEMIC LIFE SCIENCE

37

Division of SystemicLife Science

Laboratory of Cellular and Molecular
Biomechanics

Laboratory of Genome Damage Signaling■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor

ADACHI, Taiji
INOUE, Yasuhiro
KAMEO, Yoshitaka■ Main theme

TAKATA, Minoru
ISHIAI, Masamichi■ Main theme

Our research group aims to clarify the mechanisms

DNA damage response (DDR) is the fundamental

by which cells sense mechanical stimuli and regulatemechanism that stabilizes our genome. Genome

their activities in tissue adaptation, regeneration

stability underlies all biological processes. We try

and stem cell differentiation in morphogenesis.

to identify molecules involved in genome stability/

To better understand the mechano-regulation of

replication stress/DDR by methods such as screening

these dynamical processes through the complex

mutations in human patients, and further analyze theirhierarchical structure-function relationships, bridging

function using genome engineering in various cell

spatial and temporal scales from microscopiclines, iPS cells, and model organisms.

molecular/cellular activities to macroscopic tissue
behaviors is very important. Based on multiscalebiomechanics, our group is involved in the integrated
biomechanics and mechanobiology researches ofmodeling and simulation combined with experiments,
focusing on mechano-biochemical couplings in thesystem dynamics.
1. Biomechanics and mechanobiology studies on stem
cell differentiation, morphogenesis, and remodelingin tissue development and regeneration.
2. U n d e r s t a n d i n g m e c h a n i s m s o f t i s s u edifferentiation and regeneration emerged frommulticellular dynamics.
3. Identifying mechanisms of tissue functional
adaptation by remodeling to mechanicalenvironment
4. Elucidation of mechano-biochemical couplingmechanisms in mechanosensory cells.
5. Nano- and microengineering of artificial systems
combined with biomolecular and cellular systems.

Multiscale computational
biomechanics on tissuemorphogenesis

Nano-mechanicalmeasurement of biomolecules

http://www.frontier.kyoto-u.ac.jp/bf05/
index-e.html

38

DIVISION OF SYSTEMIC LIFE SCIENCE

http://house.rbc.kyoto-u.ac.jp/late-effectLaboratory of Cancer Cell Biology

Laboratory of Chromatin Regulatory
Network■ Professor■ Associate Professor

HARADA, Hiroshi■ Main theme

IKURA, Tsuyoshi■ Main theme

Cells maintain their function and morphology by

The purpose of our research is to clarify the role of

exploiting a suitable adaptive response system tochromatin dynamics, which is required for the DNA

diverse and complex tissue microenvironments. Several

metabolisms such as transcription, DNA replication,lines of evidence have suggested that hypoxic, acidic

and DNA repair. In particular, we focus on theand nutrients-depleted microenvironments exist inmolecular mechanisms by which histone modifiersolid tumors and induce malignant phenotypes andcomplexes regulate the histone eviction as chromatinchemo/radioresistance of cancer cells (Figure 1). We

remodeling machinery upon DNA damage induced

aim at elucidating molecular mechanisms responsible

by ionizing radiation. Our goal is to understand how

for cellular adaptive responses to the tumor-specifichistone eviction activates DNA damage signaling

microenvironments and malignant progression ofpathways and functions as an anti-cancer signaling.

cancer cells (Figure 2).

Main research topics· Cellular adaptive responses to diverse and· Memory of genomic damage

complex tissue microenvironments· Cellular robustness in genomic stress response· Molecular mechanisms underlying malignant· Solution of energy metabolism mechanism inprogression and radioresistance of cancer cells

specific cancer cell

· Regulatory mechanisms of carbohydrate
metabolic pathway

Figure 1: Hypoxic tumor cells (green) distant from blood vessels(blue) are resistant to radiation-induced DNA damage(red).

Figure 2: HIF-1-mediated gene networks responsible for both
adaptive responses to hypoxia and malignant
progression of cancer cells.

http://radiotherapy.kuhp.kyoto-u.ac.jp/

http://house.rbc.kyoto-u.ac.jp/

biology/mutagenesis2/index1

DIVISION OF SYSTEMIC LIFE SCIENCE

39

Organization (2017)
DIVISION OF INTEGRATED LIFE SCIENCE
Department

Laboratory
Chromosome
Transmission
Gene Mechanisms
Gene Biodynamics
Cell Cycle Regulation
Cell Recognition andCell andPattern Formation
Developmental Biology
Signal Transduction
Plant Gene andTotipotency

Applied Molecular
Biology

Responses toEnvironmental Signals
and Stresses

Professor

Associate Professor

Lecturer

Assistant Professor

NAKASEKO,Yukinobu
ISHIKAWA,Fuyuki

SHIRAISHl,Hideaki
MIYOSHI,Tomoichiro

UEMURA,Tadashi

USUI,Tadao

NISHIDA,Eisuke

Plant Molecular Biology KOHCHl,Takayuki
Molecular and Cellular
SATO,Fumihiko
Biology of Totipotency
Biosignals and
NAGAO,Masaya
Response
Applied Molecular
FUKUZAWA,Hideya
Microbiology
Molecular Biology of
KATAYAMA,Takane
Bioresponse
Plant Developmental
ARAKI,Takashi
Biology

KUSAKABE,Morioh
NISHIHAMA,Ryuichi
ENDO,Tsuyoshi

SADAIE,Mahito
HATTORI, Yukako
KONDO,Takefumi
MIYATA,Yoshihiko
YAMAOKA,Shohei
SUETSUGU,Noriyuki
IFUKU,Kentaro

KAMBE,Taiho

NISHINO,Katsutoshi
YAMANO,Takashi
KAJIKAWA,Masataka

MASUDA,Seiji

KATOH,Toshihiko

ENDO,Motomu

Plasma Membrane
YOSHIMURA,Shigehiro
and Nuclear Signaling
Genome
MATSUMOTO,Tomohiro
Molecular andMaintenance1
Developmental Biology
Developmental*
KENGAKU,Mineko
Neurobiology2
Molecular and Cellular
FUJITA,Takashi
KATO,Hiroki
Immunology3
Mammalian Molecular
Molecular and Cellular Biology3
Biology *Developmental
KAGEYAMA,Ryoichiro
OHTSUKA,Toshiyuki
Dynamics3
3
Ultrastructural Virology NODA,Takeshi

KUMETA,Masahiro
FURUYA,Kanji

KOBAYASHI,Taeko
NAKANO,Masahiro*Cooperation Course 1) Radiation Biology Center, 2) Institute for Integrated Cell-Material Sciences (iCeMS), 3) Institute for Frontier Life and Medical Sciences

DIVISION OF SYSTEMIC LIFE SCIENCE
Department

Laboratory
Professor
Single-Molecule Cell
WATANABE,Naoki
Molecular and System Biology
Biology
Bioimaging and Cell
MATSUDA,Michiyuki
Signaling
Molecular and Cellular
YONEHARA,Shin
Biology
Animal Development
Immunobiology
and Physiology
Molecular Cell Biology
MATSUZAKI,Fumio7
and Development **Molecular
NEGISHl,Manabu
Neurobiology
Signal Transductions
Genetics
IGAKI,Tatsushi
Functional Biology

Functional Biology

KAKIZUKA,Akira

ScienceCommunication andBioethics
Biology Education and Science
HEJNA,James Alan
Communication
Heredity
Bioeducation
CHISAKA,Osamu
Chromosome Function
and Inheritance
Cell Regulation and
SUGITA,Masahiko
Molecular Network4
TOMONAGA,Keizo
RNA Viruses4
Cell Division and
TOYOSHIMA,FumikoDifferentiation4

Associate Professo

TERAI,Kenta
IMAYOSHI,Itaru

Lecturer

Assistant Professor
YAMASHIRO,Sawako
MIZUNO,Hiroaki
IMAJO,Masamichi

SAKAMAKl,Kazuhiro
TAKAHARA,Kazuhiko
KITAJIMA,Tomoya 7
TAKASATO,Minoru7
KATO,HironoriOHSAWA,Shizue
IMAMURA,Hiromi

ENOMOTO,Masato
SASAOKA,Norio
TANIGUCHI,KiichiroCARLTON,Peter
MORITA,Daisuke
HIJIKATA,Makoto
ODA,Yukako
MATSUMURA,Shigeru

5

Genetic Information
SHIMIZU,Akira
Mammalian Regulatory
Cellular and Molecular
Network *ADACHI,Taiji
4
Biomechanics
Genome Damage
TAKATA,Minoru
Signaling6
Cancer Cell Biology6
HARADA,Hiroshi
Chromatin Regulatory
Network6

INOUE,Yasuhiro

KAMEO,Yoshitaka

ISHIAI,Masamichi

IKURA,Tsuyoshi*Cooperation Course 4) Institute for Frontier Life and Medical Sciences, 5) Institute for Advancement of Clinical and Translational Science,6) Radiation Biology Center**Collaboration Course 7) RIKEN Center for Development Biology

Organization

41

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/accesss//

Faculty of Medicine Bldg.F □Laboratory of Bioimaging and Cell Signaling ▼RIKEN Center for Developmental Biology▼Laboratory of Moleculer Cell Biology
and Development

South Campus Research Building for □Integrated Life Sciences / Building G
Laboratory of Chromosome Transmission ▼Laboratory of Cell Cycle Regulation ▼Laboratory of Cell Recognition and ▼Pattern Formation
Laboratory of Plasma Membrane and ▼Nuclear Signaling
Laboratory of Molecular and Cellular Biology ▼Laboratory of Immunobiology ▼Laboratory of Molecular Neurobiology ▼Laboratory of Science Communication ▼Laboratory of Bioeducation ▼Laboratory of Chromosome Function and Inheritance ▼Graduate School of Biostudies (Oﬃce) ▼

KYOTO

KOBE

OSAKA

to Kokusai kaikan

Kitaoji St.

Science Frontier Laboratory □Higashi-ichijo

Karasuma Imadegawa

Imadegawa St.

Kawaramachi St.

Karasuma St.

Horikawa St.

Radiation Biology Center □Laboratory of Genome Maintenance ▼Laboratory of Genome Damage Signaling ▼Laboratory of Cancer Cell Biology ▼Laboratory of Chromatin Regulatory Network ▼Kyoto Imperial Palace

Laboratory of Functional Biology ▼Marutamachi St.
Oike St.

Tozai Line

Faculty of Medicine Bldg.A □Laboratory of Single-Molecule Cell Biology ▼Faculty of Pharmaceutical □Sciences Main Bldg.

Gojo St.

Higashioji St.

Konoe St.

Kawabata St.

Marikoji St.

Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

Karasuma Line

Shitijo St.

Laboratory of Genetics ▼1

Shijo St.

Hankyu Ry.

to Osaka

to Osaka

Kyoto Sta.
Kintetu Line

to Nara□ Institute for Frontier Life and Medical Sciences Bldg. No. 2▼ Laboratory of Molecular and Cellular Immunology▼ Laboratory of Developmental Dynamics▼ Laboratory of Ultrastructural Virology▼ Laboratory of Cell Regulation and Molecular Network▼ Laboratory of Cell Division and Diﬀerentiation□ Institute for Frontier Life and Medical Sciences Bldg. No. 3▼ Laboratory of Cellular and Molecular Biomechanics
Kasuga St.

□ Molecular Biology Research Bldg.
Faculty of Medicine Center for Genomic Medicine▼ Laboratory of RNA Viruses▼ Laboratory of Genetic Information

42

Map & AccessNorth Campus Research Building □for Integrated Life Sciences
Laboratory of Gene Biodynamics ▼Laboratory of Plant Molecular Biology ▼Laboratory of Biosignals and Response ▼Laboratory of Applied ▼Molecular Microbiology
Laboratory of Molecular ▼Biology of Bioresponse
Laboratory of Plant ▼Developmental Biology

Faculty of Agriculture (Main Bldg.) □Laboratory of Molecular and ▼Cellular Biology of Totipotency

Faculty of Science (Bldg. No.2) □Laboratory of Signal Transduction ▼to Kurama
Eizan Ry.

Ke

ifu

ku

Lin

e.

2

Mt. YoshidaaKonoe St.

Jingu Marutamachi Sta.

Shirakawa
Shi
a St.

Hyakumanben

Kyodai
Seimon-mae

Keihan Line

Kamo River

DemachiYanagi Sta.

St.
egawa

Imad

anben

to Hyakum

2
North Campus

Hyakumanben

3
1

Imadegawa St.

Sanjo Sta.
to Yamashina

Gion Shijo Sta.

Higashioji St.

N

JR Lineto Tokyoto Osaka

Higashi Ichijo St

Main Gate

Higashioji St.

□ Institute for Integrated
Cell - Material Sciences(iCeMS) Research Bldg.
▼ Laboratory of Developmental
Neurobiology

3
Konoe St.

Main Campus

Map & Access

43

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

kyomu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/