The Guideline for Application for 2019 NIG-JOINT(Joint Research and Research Meeting)National Institute of Genetics,
Research Organization of Information and Systems
1. The Guidelines for Application(1) NIG-JOINT
National Institute of Genetics solicits Joint Research to be conducted between researchers
from other universities or institutes and NIG faculties using NIG facilities and equipmenton the proposed project. There are three types of research project: NIG-JOINT (A),NIG-JOINT (B) and NIG-JOINT (I).
As a general rule, travel expenses are provided to the researchers visiting NIG.
NIG-JOINT projects should be conducted during the period of time from April 1st, 2019 toMarch 31st, 2020. Applicants may submit applications with the same research subject as
a new application up to three consecutive years.
① NIG-JOINT (A)・Eligible applicants are researchers affiliated with domestic or overseas universities or
research institutes. Travel expenses are provided for researchers visiting NIG for theJoint Research.
・Up to 200,000 JPY can be requested by an applicant.
② NIG-JOINT (B)・Eligible applicants are researchers affiliated with domestic or overseas universities or
research institutes. Travel and research expenses (supplies and other expenses usedwithin NIG, in principle) required for the joint research are provided.
・The joint research should be planned and conducted such that applicant or his/hercollaborative research members whose names are listed on the application stay at NIG
for more than 7 days in total during the research period.
・Up to 1,000,000 JPY can be requested by an applicant for travel and research expenses.
・Limited numbers of applications are to be accepted compared to (A).
・As an option, you can simultaneously apply for NIG-JOINT (A), in case where (B)application is not approved. If you wish to take this option, please put a circle mark andfill in your budget for (A) (up to 200,000 JPY) in the appropriate spaces in theapplication.
③ NIG-JOINT (I) －International Joint Research －・Eligible applicants are researchers affiliated with overseas universities or researchinstitutes. Travel expenses are provided to researchers visiting NIG for conducting Joint
Research only.
・More than 200,000JPY up to 500,000JPY can be requested by an applicant.
・Projects to be selected will be around 5.
・As an option, you can simultaneously apply for NIG-JOINT (A), in case where (I)application is not approved. If you wish to take this option, please put a circle mark andfill in your budget for (A) (up to 200,000 JPY) in the appropriate spaces in theapplication.

(2) Joint Research Meeting
The research meeting will be held among small number of researchers from inside andoutside of NIG. The travel expenses are provided for the visit to NIG, because the meetingshould be held at NIG.
The meeting must be held in the period from April 1st, 2019 to March 31st, 2020.
・Eligible applicants are NIG faculties and researchers affiliated with domestic oroverseas universities or research institutes and travel expenses for attending themeeting will be provided.
・Up to 500,000JPY can be requested by an applicant.
2. Applicants
The applicants should be, as a general rule, researchers affiliated with universities,
inter-university collaborative research institutes and independent administrative
organizations in Japan or researchers affiliated with overseas universities or research
institutes. Please note that graduate students are not eligible to apply, but they can be amember of joint researchers.
3. Application(1) Before submitting the application, the applicant must consult closely with theprospective NIG partner regarding project subject, title of research meeting, members,
budget and other necessary matters. Research outlines and contact information ofNIG researchers are described in the attached sheet.
(2) When applying for this program, please fill out the prescribed application form andobtain approval from the head of your organization (or department). No signature orofficial seal is required.
(3) Application in word format must be e-mailed to the address below. When e-mailingyour application materials, please enter subject line as follows: “Application forNIG-JOINT + your name”. You will be notified by e-mail within 3 working days after
receiving your application documents. If you do not hear from us within a reasonable
period of time, please make sure to contact us.
Prescribed form of application can be downloaded from the NIG website at:https://www.nig.ac.jp/nig/research-infrastructure-collaboration/nig-collaboration-grant【Send your application to】kyodo-mail@nig.ac.jp (Research Promotion Team)
4. Application Deadline
Applications must arrive no later than midnight (12:00am) on December 14th, 2018.
(Japan standard Time)
5. Selection
The outcome of selection and amount of budget allocation are determinded after
screening by NIG committee and notified to the applicants via e-mail by the end of March
2019. Applications from those who have been adopted as research representatives,
regardless of whether it is a new or a continuous project, are reviewed, taking past budget
implementation status into consideration. If none of the budget has been spent in the past
project, it will be a disadvantage to the applicant. If the unused budget is refunded,accompanied by a written statement of reasons, the budget implementation status doesn’t
affect the selection in the next and following years.
6.Change of the Contents of Application
If there is a change in applicant’s or joint research member’s organization or position, oraddition of a new member, it must be immediately reported to NIG representative. If
applicant’s affiliation is changed, a letter of approval from new organization should besubmitted. (No official seal or signature is required.)
7. Expenses Provided(1)The travel and research expenses are to be provided by NIG based on the rules ofResearch Organization of Information and Systems (ROIS). Because the expenses areallocated only to NIG, not to other organizations, they should be claimed through NIG
representative. Accommodation fee for those who stay at our guest house will be
2,500JPY/night, and for those who stay at a hotel in the city will be 6,000JPY/night.
(Outside researchers visiting NIG for attending meeting or conducting research are tostay at our guest house, as a general rule.) Please note that the travel expenses could not
be fully provided in case other business or private site visits are included in the entiretrip.
(2)Applicants are expected to spend the budget at an earlier stage. If you are not able tospend none of the budget due to unavoidable reason, please submit a statement of reason(free format) and refund it by the end of December. When it becomes obvious that theexpenses are not used anymore, please contact Research Promotion Team at that time.
8. Submission of Research Report
The report of Joint Research or Research Meeting should be submitted within 30 days
after finishing the research.
9. Publication of Research Result
You are requested to acknowledge NIG Joint Research as follows when results based on
this research project are published, and send a copy of papers (PDF file is acceptable) toResearch Promotion Team.
NIG-JOINT (Reference Number)*Reference number【Serial Number + Category (A,B or I) + year】, will be issued in theAcceptance Notification which will be sent to the successful applicant.
Example:（Successful Applicant：Taro Iden, Reference Number：1A2019）“This work was supported by NIG-JOINT (1A2019) to T. Iden.”
10. Others(1) NIG facilities and equipment are available to be used for the Joint Research andResearch Meeting.
(2) When holding Research Meeting, NIG representatives are requested to post themeeting program on the NIG website and give notice to all NIG members by at least
one month prior to the date of the meeting.

(3) If gene recombination and/or animal experiments are planned, NIG representatives
are requested to submit Experiment-on-Gene Recombination plan and/orExperiment-on-Animals plan application form to Research Promotion Team after
acceptance of the application. As for animal experiments, researchers directly handle
experimental animals are requested to apply for NIG qualification screening andundergo a training regardless of their affiliation. We strongly hope that all researchers
comply with regulations and conduct the research properly.
(4) Researchers who handle Radioisotope at NIG are requested to register as Radiation
Worker before starting to handle it.
(5) Outside researchers visiting NIG for attending meeting or conducting research are tostay at our guest house, as a general rule.
However, they can stay at a hotel in the city if the guest house is fully booked.
(6) Ownership of intellectual property rights created in the Joint Research of NIG will beconsidered based on the regulations of ROIS employee invention.
(7) NIG assures that private information for this application should be used only forscreening the proposal. Regarding the accepted proposal, the representative of theresearch, his/her institute and the research project title will be posted on NIG website
and annual reports.
(8) As a general rule, NIG would not prepare the form of “business-trip request” for theJoint Research and Research Meeting to simplify the procedures.
We sincerely ask outside researchers visiting NIG to follow appropriate business trip
procedures according to the rules of their affiliated institute.

【Contact/Inquiry】
Department of Administration
Research Promotion Team, General Affairs and Project Section
National Institute of Genetics, Research Organization of Information and Systems
Yata1111, Mishima, Shizuoka, 411-8540 JAPAN
Phone: +81-55-981-6728
E-mail: kyodo-mail@nig.ac.jp

Research outline（Updated: January 1st,2019）
Department
Department ofInformatics

Laboratory

Gene- Expression
Analysis

Faculty

OKUBO, Kousaku / Professor

Genetic Informatics KAWAMOTO, Shoko /Associate Professor

Genome Evolution

KUROKAWA, Ken / Professor
MORI, Hiroshi / Assistant Professor

BiologicalNetworks

ARITA, Masanori / Professor

GenomeInformatics

NAKAMURA, Yasukazu / Professor

Research andDevelopment ofBiological
Databases

KAWASHIMA, Takeshi / Assistant Professor

TANIZAWA, Yasuhiro / Assistant Professor
TAKAGI, Toshihisa / Professor*To be retired on March 31st,2019Research outline“How can we make use of data and information at our
finger-tip in making smarter decisions in our own
contexts?” Without solving this question, all analytical anddescriptive efforts that digitalize the reality end up in vain.
Our tentative answer/goal for this is to develop method toenhance “fluidity” and “utility"of medical knowledge among
humans and machines.
We are working on research and development of databases
and information retrieval system for the national
bio-resource project(NBRP).
We are interested in understanding about microbial
genome evolution and microbial community dynamics, andwe are currently reaching out in the following two major
research directions; I. Facilitate the development of an
integrated database “MicrobeDB.jp”, II. Microbialcommunity dynamics.
Network analysis of metabolic pathways based oncomprehensive identification and quantification ofmetabolites (metabolomics); Bioinformatics related to plantsecondary metabolism and lipid metabolism
Intelligent information technology for structural andfunctional annotations of large-scale nucleotide sequences.
We are researching to apply distributed databasetechnology and/or parallel-distributed computing
technology to huge life science databases including DDBJ.
Studies on analyzing biological data with using
supercomputer.

Department ofGenomics andEvolutionary Biology

DNA Data Analysis

Population
Genetics

Plant Genetics

IKEO, Kazuho / Associate Professor

SAITOU, Naruya / Professor
JINAM, Timothy / Assistant Professor
SATO, Yutaka / Professor
TAKAHASHI, Misuzu / Assistant Professor
SUZUKI, Toshiya / Assistant Professor

EvolutionaryGenetics
Human Genetics

Ecological Genetics

Department of Gene
Function andPhenomics

AKASHI, Hiroshi / Professor
MATSUMOTO, Tomotaka / Assistant Professor
INOUE, Ituro /Professor
NAKAOKA, Hirofumi / Assistant Professor
KITANO, Jun / Professor
ISHIKAWA, Asano / Assistant Professor

Comparative
Genomics

TOYODA, Atsushi / Project Professor

Gene Network

SUZUKI, Emiko / Associate Professor

Evolutionary study of genomic structure and gene
expression pattern to elucidate the evolutionary
mechanism of central nervous system and sensory organs.
Evolutionary genomics analysis of various species.
Metagenome analysis.Developing databases and computer
software for biological research.
We study evolution of genes and genomes, in particular
human evolution. We also develop methods for study ofgenome evolution.
The goal of our research is to understand molecularmechanisms governing early processes of plantdevelopment using a series of rice embryogenesis defectivemutants. Currently we are focusing on the mechanism ofregulating the cell division pattern and plasticity incellular differentiation in rice embryo.
Mechanisms of genome evolution. Especially weak
selection and biosynthetic constraints.
Medical genomic study using high-throughput sequencing
data is a promising procedure to create an innovate
healthcare system and open a new aspect of population
genetics.
We use threespine stickleback fishes to investigate thegenetic and molecular mechanisms underlying adaptationand speciation.
We have been conducting advanced genomics research on
the plasticity of genome structure and functions using mostadvanced genome technology such as New-Generation
Sequencers.
Combinations of molecular genetics of Drosophila andhigh-resolution light and electron microscopy are employed
to study functional implication of structural and molecularorganization of cells.

Symbiosis and CellEvolution

MIYAGISHIMA, Shin-ya / Professor

Model Fish
Genetics

SAKAI, Noriyoshi / Associate Professor

Plant Cytogenetics

FUJIWARA, Takayuki / Assistant Professor

KAWASAKI, Toshihiro / Assistant Professor
NONOMURA, Ken-ichi / Associate Professor
TSUDA, Katsutoshi / Assistant Professor

Mammalian Neural IWASATO, Takuji / Professor
Circuits
NAKAGAWA, Naoki / Assistant Professor
MulticellularOrganization
Brain Function

SAWA, Hitoshi / Professor
HIRATA, Tatsumi / Professor
KAWASAKI, Takahiko / Assistant Professor
YAN, Zhu / Assistant Professor

Molecular andDevelopmental
Biology
Mammalian
Development
Microbial
Physiology

KAWAKAMI, Koichi / Professor
ASAKAWA, Kazuhide / Assistant Professor
MUTO, Akira / Assistant Professor
SAGA, Yumiko / Professor
KATO, Yuzuru / Assistant Professor
AJIMA, Rieko / Assistant Professor
NIKI, Hironori / Professor
AOKI, Keita /Assistant Professor

In order to understand endosymbiotic evolution of
eukaryotes, we are studying coordinating mechanisms ofeukaryotic cell and organelle/endosymbiont proliferation
using algae, plants, and protists.
We establish reliable protocols for genetically modificationof zebrafish using sperm, and analyze the molecularmechanisms of spermatogenesis and early development inzebrafish.
We aim to elucidate the regulatory system of plant
germ-cell development and chromosome kinetics, mainly
using seed-sterile rice mutants.
We are studying molecular and cellular mechanisms ofneuronal circuit development in the mammals, using
mouse genetics and other related methods.
We are studying the mechanisms that produce a variety ofcell types through asymmetric cell divisions using thenematode C.elegans.
Development of the vertebrate nervous system with special
focus on neuronal network formation.
Genetic studies on development, morphogenesis andbehaviors by using a model vertebrate zebrafish.
We study the early developmental events and theregulatory mechanisms during mouse embryogenesis
through generation and analyses of gene-knockout andtransgenic mice. We are especially interested in the organs
derived from mesoderm (heart, lung, somite), and the germ
cell system.
We investigate higher order structure of chromosomes andtheir dynamics in yeast and bacteria through genetic andcell biological analysis.

SHIROISHI, Toshihiko / Professor
Mammalian
Genetics

Mouse Genomics
Resource

Department ofChromosome ScienceEpigenomics*To be retired on March 31st,2019

TAKADA, Toyoyuki / Assistant Professor

KOIDE, Tsuyoshi / Associate Professor
TAKANAMI, Keiko /Assistant Professor
KAKUTANI, Tetsuji / Professor
TARUTANI, Yoshiaki / Assistant Professor
INAGAKI, Soichi / Assistant Professor

Genome Dynamics

MAESHIMA, Kazuhiro / Professor
IDE, Satoru / Assistant Professor
HIBINO, Kayo / Assistant Professor

Cell Architecture

Microbial GeneticsMolecular Cell
Engineering

KIMURA, Akatsuki / Professor
TORISAWA, Takayuki / Assistant Professor

ARAKI, Hiroyuki / Professor

KANEMAKI, Masato / Professor
NATSUME, Toyoaki / Assistant Professor

In order to understand genetic regulation of complex traits,
such as morphogenesis and energy metabolism, we areconducting genetic analyses using mouse spontaneous
mutants (variants) and genetically modified mutants.
For understanding genetic basis of behavioral diversity,
behavioral and genetic analyses are applied on a variety ofmouse resources including wild-derived strains. We aredeveloping genome editing methods in mice for analyzing
function of genes.
Control and function of epigenetic gene modifications in
Arabidopsis.
Our research interest lies in determining how a long stringof genomic DNA is three-dimensionally organized in living
cells, and how the organized genome functions duringcellular proliferation, differentiation, and development. We
are using a novel combination of molecular cell biology andbiophysics to elucidate 3D-organization and dynamics ofhuman genome chromatin.
To understand the three-dimensional architecture of thecell and its dynamics, quantitative imaging and modelingapproaches are employed. Specific targets of the research
are size and shape of organelles, the mechanics ofcytokinesis, and cytoplasmic streaming in the C. elegans
embryo.
Genetic and biochemical approach to elucidate molecularmechanism and regulation of eukaryotic DNA replicationand checkpoint control using budding yeast
To understand DNA transactions in human cells, wegenerate conditional cells using the auxin-inducible degron
technology for genetic and cytological analyses. We also
develop new technologies for construction of mutant humancells.InvertebrateGenetics

Center for Frontier
ResearchSAITO, Kuniaki / Professor
KONDO, Shu / Assistant Professor
MIYOSHI, Keita / Assistant Professor

Cell Dynamics andOrganization

ODA, Yoshihisa / Associate Professor

SystemsNeuroscience

KUBO, Fumi / Associate Professor

Chromosome
Biochemistry

MURAYAMA, Yasuto / Associate Professor

Quantitative
Mechanobiology

SHIMAMOTO, Yuta / Associate Professor

Advanced Genomics
CenterNOGUCHI, Hideki / Project Professor

Radioisotope Unit

ANDACHI, Yoshiki / Assistant Professor

We investigate molecular mechanisms of Drosophila gene
expression and repression through biochemical and genetic
techniques. Especially, we are focusing on the small RNA
pathways and chromatin regulation during germ cell
development.
To understand the mechanism underlying plant cell wall
patterning, we study the dynamic behavior of cortical
cytoskeletons and small GTPases in xylem cells.
We study how visual information generates goal-directedbehavior. We aim to understand the neural circuitmechanisms underlying this process using a combination ofgenetic, optic and behavioral approaches in zebrafish.
We investigate molecular mechanism underling regulationof chromosome organization and dynamics byrecapitulating their biochemical reactions using purifiedproteins. We now especially focus on SMC complexes.
Our laboratory studies mechanisms of force-based
regulation in the mitotic spindle and the cell nucleus.
Using our expertise of controlled mechanical manipulationand high-resolution fluorescence imaging, themicro-mechanics of these intracellular structures,assembled in Xenopus egg extracts, are quantitativelyanalyzed.
Development of new algorithms for de novo sequenceassemblies, and analytical tools for comparative genomics
employing massive data produced from next generation
sequencers.
We study microRNA-mediated post-transcriptional
regulation in C. elegans using our original methods for thedetection of microRNAs and target genes.