GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITYINDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

7

Features of Education …………………………………………………………………

9

Description of Lectures held in English ………………………………… 10
Outline and Composition of Departments …………………………… 12
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 13
Department of Gene Mechanisms ………………………………………………… 14
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Department of Cell and Developmental Biology ……………………………… 15
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 16
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 17
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 19
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 20
Laboratory of Genome MaintenanceLaboratory of Nanobiology
Laboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 21
Laboratory of Molecular and Cellular Immunology
Laboratory of Mammalian Molecular Biology

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 23
Department of Molecular and System Biology…………………………………… 24
Laboratory of Neuroscience
Laboratory of Bioimaging and Cell Signaling

INDEX

Department of Animal Development and Physiology ………………………… 25
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology and Development
Department of Signal Transductions ……………………………………………… 29
Laboratory of Molecular Neurobiology
Laboratory of Genetics
Department of Functional Biology ………………………………………………… 30
Laboratory of Functional Biology
Department of Biostudies and Society …………………………………………… 30
Laboratory of Science Communication and Bioethics
Department of Mammalian Regulatory Network ……………………………… 31
Laboratory of Cell Regulation and Molecular Network
Laboratory of Viral Oncology
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information

Organization ………………………………………………………………………… 33
Map & Access ……………………………………………………………………… 34
Contact ………………………………………………………………………………… 36

Greeting fromthe Dean of
the Graduate School
Dean: ISHIKAWAISHIKAWA, Fuyuki,
Fuyuki MD,
MD PhDESTABLISHMENT AND HISTORY
OF THE GRADUATE SCHOOL OF
BIOSTUDIESThis experience lead us to be selected as one of theschools of the 21ST Century COE Program（21 世 紀 COE
プログラム）in 2002. Furthermore, we were selected as aschool of the “Initiative Project for Attractive Education

Life Science is the study of life in all of its forms andin Graduate School（ 魅 力 あ る 大 学 院 教 育

イニシア

complexity. It encompasses the totality of life forms” and the “Support Program for Education
テ ィ ブ 事 業）

from viruses and bacteria to human beings, and its

Reformation of Graduate School（大学院教育改革支援プ

analyses involve molecules, genes, cells, tissues, living” in 2006 and in 2008, respectively.
ログラム）

organisms, and eco-systems in diverse phases. Life is

We are proud of our educational program. With

not a “molecular machine”. Therefore, it is necessary

support from a variety of projects, we have been diligent

to bring the context of life into the research effort. It

to provide bold and efficient curriculums that reflect therequires using various approaches, various disciplines,

students’ feedback and discussions with teaching staff

and various fields of study. In addition, those who wish

and administrators, who are passionate to improve theto excel in the life sciences must bring to their studies a

graduate education system. We attach particular weightstrong sense of ethics. Biostudies researchers must be

to nurturing students’ autonomous attitudes, allowing

more than manipulators of molecules.

students to develop their own thoughts and originality,

Those trained in specialized disciplines within

to have their own voice and points of view presenting

agriculture, medicine, and pharmacology, where

their own ideas, and to solve problems with innovative

studies in the life sciences were traditionally pursued inapproaches. New discoveries arising from their daily

the past, have independently contributed greatly to

training should be shared at the global level. With thisthe current knowledge base. These accomplishments

goal in mind, a foreign professor, who is a native English

notwithstanding, it is manifestly essential for researchers

speaker and experienced in Life Science research,

to place their work within the whole framework of “Life”

instructs students to improve their discussion, writing, andand to encourage each other as people who love

presentation skills. Students are encouraged to present

life. With such needs and expectations both internally

their research at international meetings, and dissertations

and externally, the Graduate School of Biostudies was

are now accepted in either Japanese or English.

established in 1999, to engage in 21st Century Life
Science as a comprehensive science.

Our research has been frequently cited andis ranked at the forefront of the global scene. Our

It has been 15 years since the school was established.

faculty, who have diverse backgrounds, explore new

In that time, we have accepted numerous students anddirections of research, sharing their own knowledge,

have sent into society graduates who were raised toskills, and ideas with frank discussion in the appropriate

be outstanding researchers through the leadership offorums of the public and research environment. We are

our former deans, Kanji Ohyama, Mitsuhiro Yanagida,

actively collaborating with private/public sectors andKayo Inaba, Eisuke Nishida, and Shin Yonehara.

are attracting competitive external public funding for

Simultaneously, we have published many cutting-edge

research. At the same time, we strongly hope that the

research findings.

fruits of our research will contribute to social happiness.

In 2001, we were selected as an educational base of

Most of our laboratories are located at the Souththe MEXT Center of Excellence Formation Project（COE）.

Campus and the North Campus, improving their research

4

GRADUATE SCHOOL OF BIOSTUDIES

and education in the respective research complexes.

School of Biostudies.

Despite the physical distance between the campuses,(1) The Division of Integrated Life Sciences: cell devel-

the graduate students and teaching/administrative

opment, cell growth, genetic information and cell

staff communicate closely, while upholding the tradition

cycle regarded as a multicellular system, and thethat respects diversity and free-ranging inquiry. This has

totipotency, the mechanism of signal transduction

also engendered a friendly and lively atmosphere toand the responses among the cell, living being andencourage each other.

environment.

All in all, we are pioneering a new Life Science withhope and responsibility. We recognize our responsibility(2) The Division of Systemic Life Sciences: neuroscience,

and are full of hope and confidence that we can reachanimal development and physiology, immunobiol-

our goals. Although we are still a young organization, or

ogy and others.

perhaps because we are a young organization, we will
do our best to bring our school mission and the research

AIMS OF THE GRADUATE SCHOOL OF BIOSTUDIES

fields listed below to fruition. We sincerely appreciate(1) Training of individuals with the most advanced

your further support.

knowledge of the life sciences for the next generation

The three goals of the graduate school(1) Provide education for pursuing the new biostudies at
the world's top level

The graduate student studies a higher level of life
sciences beyond the structures of past life sciencerelated fields at each undergraduate level to un-

To meet the demands of the industry, college,

derstand the integrated life sciences. The goal is toresearch institutes and administrative organizations,nurture a new type of individual with creative andindividuals are educated in the life sciences andinnovative abilities to cope with the various unknown

master the techniques for the society needs.

themes to be confronted by human beings in thenext generation.

(2) Train individuals to apply the new life sciences forthe protection of the global environment and for human welfare(2) Training to establish self for society
In the Graduate School of Biostudies, individuals

Integrate the knowledge and technology inare trained to make a healthy and fair judgment

the old fields of science, agriculture, medicine andbased on the academic background of the staff

pharmacology, and nurture individuals who canand their prospects for the future; and, establish acontribute to the human society in the 21st century.

new system to evaluate the effects of educationfrom multiple aspects from the past.

(3) Nurture individuals who can understand the various
vital phenomena of the living organisms as a systemic function, and pursue these systemic functions(3) Activation and flexibility of staff in the human relations

Nurture individuals who will be leaders in the human

Research is pursued by each staff member inde-society to pursue their activities for the welfare and hap-pendently to develop a new life science based onpiness of humans in the 21st century, where humans will

active exchange among the various laboratories in

be living in harmony with other living beings.

the graduate school.

In order to meet the demands of the changing
society in the 21st century, which will be impossible(4) Use of current post-doctoral system and evaluationof academic activities

to cope with in the current research academic

Full use should be made of the current system, tosystem for the life sciences, a new research andprovide the increasing necessary number of instruc-education system is installed to breakdown the walls

tors per student, for the intensive training to becomethat have hindered the research in the life sciences

life scientists at an international level, for true devel-in the past. There are two courses in the Graduate

opment of a new research field.

GRADUATE SCHOOL OF BIOSTUDIES

5

Policy
Education and admission policy
The field of life sciences is transforming andevolving into an advanced branch of science thatwill build a future for humans. With this global trend
as a backdrop, the Graduate School of Biostudies
was established in 1999 as Japan’s first independent graduate school of biostudies, with the aim ofcreating one of the world’s top research institutions

3. All students are trained to become mature andhighly capable researchers who can collaborate
actively with foreign partners.
4. We offer a variety of educational curriculums including biology, medicine, and related areas.
5. We cultivate students with life ethics and astrong sense of responsibility for the world where
humanity and nature must be harmonized.

and developing human resources who will lead thenext generation in the biostudies field. With a set of

Diploma policy

such basic units of life as "cells," "molecules," and1. In the two-year Master’s program, students must

"genes" as a common language, the Graduate

take 1 credit from compulsory subjects and at

School of Biostudies is home to innovative research

least 9 credits from elective subjects offered byand educational activities, where concepts about

the school. In addition, students are required todiverse organisms and the environments that com-complete 20 credits of lab experiments and prac-prise them are integrated to create new values

tice. The degree must be accredited through theconcerning the future and respect for life.

examination of a Master’s thesis.

In response to diverse, social demands that call

2. In the Master’s program, it is necessary for stu-

for an increasingly sophisticated and complex life

dents to acquire and demonstrate knowledgesciences field, the Graduate School of Biostudies

and capability required for professional re-

strives to develop the following human resources:

searchers in the field.

1) Researchers who explore and discover the ba-

3. In the Doctoral program, students who take thesics of life, pursuing the cutting-edge field of bio-

lectures offered by the school and perform thestudies at the highest level in the world;

research for a Doctoral thesis must be enrolled

2) Researchers and highly skilled engineers whofor 3 years (or less by way of exception). Students

contribute to society at public and private re-must take 1 credit from compulsory subjects andsearch institutions, endeavoring to protect themore than 1 credit from elective subjects. For

global environment and maintain human health,lab experiments and practices, 8 credits are re-well-being, and happiness; andquired. Doctoral students must submit a Doctoral

3) Educators and highly skilled practitioners who
possess broad knowledge of diverse vital phe-thesis and pass the relevant examinations for the
degree.

nomena of living organisms and who contribute

4. In the Doctoral program, each student must

to society through education, industry, mass me-

demonstrate that he/she has the ability to work

dia, and the public sector.

as an independent researcher for successful
completion of the program.

Curriculum organization policy
1. In Master’s programs, basic knowledge of life
science and research competency are acquired.
2. In Doctoral programs, advanced knowledge
and research competency in life science are
acquired. Moreover, each student is trained to
become a researcher who plays an active roleinternationally as a group leader.

6

GRADUATE SCHOOL OF BIOSTUDIES

5. We expect that students will graduate with ashared ethical obligation to advance sciencein the best interests of mankind in harmony withnature.

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained to discuss anddebate scientific matters and research outcomes.
Students are also trained to have a broad outlook and flexible thinking in life sciences, and areencouraged to travel to international scientificmeetings.

those who cannot obtain a "college student visa"
by the end of September. Thus, applicants can select the starting date of either October 1st or April
1st in the next year. At the time of application, prospective students must identify which laboratory
head will direct their doctoral research. Applicants
can apply for only one lab. Thus, applicants should
contact the lab head and fully discuss potential
research activities and availability before filingthe application.
Admission examinations for the Doctoral program consist of: 1) an English written test to evaluate
reading comprehension and writing ability; 2) anoral presentation (in English) of a research projectthat applicants have conducted; 3) a subsequentoral examination to evaluate applicants’ knowl-“Global Frontier in Life Science”

edge of their field, research competency, logicalthinking skills, and ability to give presentations.

The Graduate Schools of Biostudies, and Medicine, and Pharmaceutical Sciences offer "Global

2) Master’s Program in "Global Frontier in Life Science"

Frontier in Life Science", a joint educational pro-

Our entrance examination for the Master’s

gram for Doctoral and Master’s students as part ofprogram is held in July. The guidelines for admission

K.U. PROFILE (Kyoto University Programs for Future

are posted in April on our web site (http://www.

International Leaders: http://www.opir.kyoto-u.

lif.kyoto-u.ac.jp/e/). The academic year starts onac.jp/kuprofile/). This program, "Global Frontier in

October 1st or April 1st for those who cannot obtain

Life Science", is held entirely in English, including

a "college student visa" by the end of September.

the entrance examinations, lectures, experiments,

Thus, applicants can select the starting date ofand discussions.

either October 1st or April 1st in the next year. Appli-

International as well as domestic students arecants to the Master’s program can apply for up to

welcome. In particular, the program welcomes

two labs in which they wish to conduct research.

those who show a respect for life and a desire toThus, applicants should familiarize themselves withcreate a comprehensive and cutting-edge field

faculty members’ research interests and contact

beyond existing disciplinary boundaries in life sci-lab head(s) to fully discuss prospective researchences.

activities and availability before filing the application.

1) Doctoral Program in "Global Frontier in Life Science"

Admission examinations for the Master’s pro-

The three graduate schools hold independent

gram consist of: 1) a set of written examinations ofentrance examinations for this program, and ac-

English proficiency and knowledge of general sub-cept up to ten applicants. Our entrance examina-

jects in biology; and 2) an oral examination. The settion for the Doctoral program is held in July. Theof written examinations is given to all applicants.

guidelines for admission are posted in April on
our web site (http://www.lif.kyoto-u.ac.jp/e/). The
academic year starts on October 1st or April 1st for

GRADUATE SCHOOL OF BIOSTUDIES

7

Lectures held in English for “Global Frontier inLife Science”
1) Doctoral program
Offered by the Graduate School of Biostudies
・Frontier in Life Science (1 credit : compulsory)
・Advanced English Discussion and Writing in Life
Science I (1 credit)
・Advanced English Discussion and Writing in Life
Science II (1 credit)
2) Master’s program
Offered by the Graduate School of Biostudies
・Life Science : From Basics to Applications, from
Molecular Biology to Systems Biology (1 credit :compulsory)
・Beginning Science (1 credit)
・Global Frontier in Life Science A (2 credits)
・Global Frontier in Life Science B (1 credit)
・Advanced Molecular and Cell Biology I (2 credits)
・Advanced Molecular and Cell Biology II (2 credits)
・Cancer Biology (2 credits)・Basic English Discussion in Life Science I (1 credit)・Basic English Discussion in Life Science II (1 credit)
Supplied by the Graduate School of Medicine
・Medical Science I (2 credits)
・Medical Science II (2 credits)
・Clinical Science Introduction (2 credits)

Requirements for completing programs
1) Requirements for completing the Doctoral program・" The Life-Science Special Exercises" (8 credits :compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 1 credit)
For graduation, the student must have enrolled
for at least three years and have completed
at least 10 credits. It is also required to pass theprobation and the examination (thesis defense)
upon completion of a Doctoral thesis written under the supervision of faculty.
2) Requirement for completing the Master’s program
・"The Life-Science Experiments and Exercises 1" (10credits : compulsory)
・"The Life-Science Experiments and Exercises 2" (10credits : compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 9 credits)

8

GRADUATE SCHOOL OF BIOSTUDIESFor graduation, the student must have enrolled
for at least two years and have completed at least
30 credits. It is also required to pass the probation
and an examination upon completion of the Master’s thesis written under the supervision of faculty.

Features of Education
Features of Education
From 2006 to 2007, we conducted the "Biostudies Career-Development Program" supported by
the Ministry of Education, Culture, Sports, Scienceand Technology. From 2008, we have launched
the "Program for Developing Pharmaceuticalthe development of English communication skills
for students. Our school has been emphasizing thedevelopment of communication skills in English. We
encourage and financially support our students togive talks at international conferences abroad. We
also give them advice for their presentation skills.

Strategists" as one of the projects of "Reforming
Programs in Education" at Kyoto University. This

3) Workshops organized by students

program, in cooperation with the Graduate SchoolStudents in life science fields tend to stay inof Pharmaceutical Sciences, is aimed to reformtheir labs because they are busy working at thethe educational system of graduate schools in ourbench. However, it is highly important to commu-

university. Launched in 2011, we are conducting

nicate with other students studying life science in-a new program named "Global Frontier in Life Sci-

side and outside of our school during the course ofence". In 2012, we were selected as one of theeducation. We encourage and financially support

schools of the “MEXT Excellent Graduate School

the students to organize and conduct workshops

Hub Formation Project ” and supported our Doc-by themselves.

toral students with the subsidy. We are hoping that
our students will understand the essential aspectsof the programs and cooperate with us in achieving their goals.

4) Guidance by multiple supervisors
Heretofore, students who were assigned totheir laboratories studied under the supervision of
one faculty member. However, it would be highly

Outline of Reforming Programs in Education
1) Lectures
In our Master’s program, the curriculum is designed to make the students systematically understand life science and its related fields. We offer aninherent lecture for understanding, revealing, andcultivating the relationship between life science andour society. In our Doctoral program, advanced
courses in life science are offered in addition to theseminars at the lab where each student belongs.
This program has been ongoing since 2006. We gear
the program to provide the requisite knowledge
and experience for the students' future careers invarious fields of Industry, Government, and Academia, at home and internationally.
2) Emphasis on English communication for life science, with support for attendance at international scientific meetings
It is now very important to give seminars in
English, especially scientific presentations at international meetings. Historically, however, the gradu-

stimulating for the students if they could haveopportunities to discuss their research and othermatters with other faculty members. In our school,
each student is strongly encouraged to consult
with two additional supervisors for his/her current
research and also career objectives. We hope thatthe practice widens their vision on life science andon their future plans.
5) Global 30(http://www.uni.international.mext.go.jp/)
The Ministry of Education, Culture, Sports, Science and Technology launched the "Global 30"
Project for Establishing Core Universities for Internationalization, for the purpose of selecting universities that will function as core schools for receiving
and educating international students. In 2009,
thirteen universities including Kyoto University wereselected. These core universities are playing a major role in dramatically boosting the number of international students educated in Japan as well asJapanese students studying abroad.

ate schools in our country scarcely cared about

GRADUATE SCHOOL OF BIOSTUDIES

9

Description of Lectures held in
EnglishMaster’s Programeral different research fields in Life Science. Lecturers are mostly young scientists, who have recently

Beginning Science ...........................................................................................................................................

started his or her own research as lab heads in Kyo-

Lecturers: Uemura, Hejna, Sengoku
Sengoku）（Lecturers:

to University. In addition, the lecturers will provide

This class will cover the history of life science, thetheir experiences how they have found enthusiasm

basic phenomena in this field, research meth-in life science researche.

odologies, papers that impressed the lecturers
themselves, seminars, and meeting other scientists,

Global Frontier in Life Science B .........................................................................

as the beginning of research. Moreover, rules ofLecturers: Hejna, Chisaka, Nishihama
Nishihama）（Lecturers:

research and proper analysis of data will be dis-International scientific communication is con-cussed. Furthermore, to broaden students’ views ofducted virtually exclusively in English. Students intheir career path, and their future roles as scientists

this class will be provided opportunities--and willin the greater context of our society, we would likebe expected--to actively practice and refine theirto discuss what Professionalism means, in terms oforal presentation skills in English. The class format

common sense, regardless of particular career ob-

will consist of medium-length (about 30 min.) stu-

jectives, and how to develop systematic and criti-

dent presentations (depending on enrollment andcal thinking skills.

group discussions, in addition to impromptu exercises to further develop reading and listening com-

Life Science:From Basics to Applications, from Molecular
Biology to Systems Biology...................................................................................................

prehension. Each class will be a standard 90 min.

Lecturers: Hejna, Nagao, Kambe, Kumeta, Toyo（Lecturers:

language fluency and presentation skills, and theshima, Harada, Inoue, Masuda）
Masudacontent will cover current topics in bioscience.

class, scheduled from 10:30 am-12 noon. The classis meant to be a forum in which to improve English

This class will be conducted entirely in English, andis designed to acquaint students with a broad

Advanced Molecular and Cell BiologyⅠ ..........................

range of research areas and methodologies, while

Lecturers: Yoshimura, Takeyasu, Yonehara, Kaki（Lecturers:

encouraging students to consider the adaptability

zuka, Kengaku, Hejna, Kumeta）
Kumetaor combination of methods in other systems. Topics

This will be a lecture course with a limited number

will range from a quick review of basic molecularof students (up to 30). The students will be given

biology techniques, to presentations on differen-

5-8 scientific papers to read. Special emphases will

tiation factors, transport proteins, applications of

be on the biologists’ way of thinking as well as thefluorescence technology, single-molecule imag-

basic concepts on the gene/protein structure anding, systems biology, synthetic biology, and the hot

function.

topic of RNA research. Discussion is also encour-

1. Logic and basic concepts in biology : What does

aged. The class is primarily for first-year Master's stu-a biologist do and what does a biologist know?

dents. Other students, especially G30 students, are

2. Methods in biology : What kinds of techniques

equally welcome.

does a biologist employ?
3. Specific topics deal with cell structure and func-

Global Frontier in Life Science A........................................................................

tion, the nucleus and central dogma

Lecturers: Kakizuka, Shin, Gerle, Wang, Ebisuya,（Lecturers:

10

Carlton, Nakamura, Woltjen, Matsuo, Kalay, Alt-

Advanced Molecular and Cell BiologyⅡ ..........................

mann, Kim, Ishikita, Shiojiri, Imamura）
ImamuraLecturers: Takeyasu, Ishikawa, Kohchi, Fujita, He（Lecturers:

Lectures in this “Global Frontier in Life Science A.”

jna, Yoshimura, Endo, Kumeta）
Kumetawill be held in English, and aim to provide basic

This course is an intensive course to introduce theand fundamental concepts and knowledge in sev-

underlying cell signaling pathways and their me-

GRADUATE SCHOOL OF BIOSTUDIESdiators covering mammalian cells, plants and mi-

sented.

crobes. The final goal of this course aims to provide
an overall knowledge regarding the diversity and

Doctoral Programsignificance of cell signaling events in response tovarious stimuli and physiological conditions, andFrontier in Life Sicence.........................................................................................................................

the generality among species. The course will be

Lecturers: Ishikawa, Ohshima, Nureki, Ishii
Ishii）（Lecturers:

held in combination with related paper discussion.

Prominent leading scientists from several researchStudents interested in cell and molecular biology

fields of life science, especially those progressing

and cell signal transduction are encouraged toastonishingly, will provide their research histories

participate.

from their backgrounds to future prospects, to encourage young scientists to perform good science.

Cancer Biology ...........................................................................................................................................................
Lecturers: Takeyasu, Ishikawa, Kakizuka, Yoshimu（Lecturers:
ra, Kumeta）
KumetaAdvanced English Discussion andWriting in Life ScienceⅠ .................................................................................................................

In this course, a wide variety of recent topics on

Lecturer: Hejna
Hejna）（Lecturer:

cancer biology will be lectured by researchers

Like it or not, career advancement depends uponworking in different research fields and different

the ability of a researcher not only to read andcountries. A Long-distance learning system com-write English, but to converse fluently in English.

bines Kyoto, Tsukuba and National Taiwan Universi-

These skills are crucial for presentations at interna-ties to promote active interaction and discussion

tional meetings, international collaborations, peer

between lectures and students, as well as among

review of manuscripts, and professional network-

students in different universities.

ing.

This course will allow you to further develop

your English language skills by giving oral presen-

Basic English Discussion in Life ScienceⅠ..........................

tations. In addition, a homework writing exercise

Lecturer: Hejna
Hejna）（Lecturer:

will give you practice in writing a short document,

Despite having excellent English reading andsuch as an abstract, a cover letter, or peer review.

writing skills, most students, even native-English

Enrollment will be limited to just 3 students, to allow

speakers, need to improve their oral English com-each student two 75-minute oral presentations,munication skills in order to thrive in the new inter-and ample opportunity for informal discussion in anational scientific community. This class is designed

low-stress environment.

to provide students with ample opportunities toviewing elements of English grammar and style as

Advanced English Discussion andWriting in Life ScienceⅡ .................................................................................................................

they arise. An added benefit will be coverage ofLecturer: Hejna
Hejna）（Lecturer:a diverse range of current scientific topics; students

This class continues the development of presenta-

will begin to look critically at scientific data, and its

tion and discussion skills in English, as in Advanced

presentation.

English Discussion and Writing in Life Science I, withpractice scientific discussions in English, while re-the longterm goal of preparing you for an interna-

Basic English Discussion in Life ScienceⅡ..........................

tional scientific career. This course will allow you

Lecturer: Hejna
Hejna）（Lecturer:

to further develop your English language skills by

This class is designed to build upon existing read-giving oral presentations. Group discussions will be

ing and writing skills by developing strengths in oral

friendly, but objective.

presentation and discussion of science in English.

writing exercise will give you practice in writing a

Aimed at Master's students in particular, who may

short document, such as an abstract, specific aims,

not yet have extensive research results to present,or peer review.

the class will consist of shorter (~30 min) student

students, to allow each student two 75-minute oralpresentations, covering recent science news,

presentations, and ample opportunity for informal

methods, and technology. Students are expecteddiscussion in a low-stress environment.

In addition, a homework

Enrollment will be limited to just 3

to contribute to the class by commenting and raising questions, at the same time strengthening theirability to look critically at the way science is pre-GRADUATE SCHOOL OF BIOSTUDIES

11

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism❖ How the brain and the body work・Department of Gene Mechanisms❖ How the body is built

log・Department of Molecular and Cellular Biology❖ How the human diseases occur
・Department of Molecular and System Biologyo❖ How multicellular organisms work
olo・Department of Cell and Developmental Biologyy・Department of Plant Gene and Totipotency
enta・Department of Molecular and Developmental
Biologyth❖ How organisms interact withenvironments

・Department of Animal Development andPhysiology
・Department of Signal Transductions
・Department of Functional Biology
Network
ory Net・Department of Mammalian Regulatory

ethics❖ Communications・Bioethics
・Department of Biostudies and Societyy・Department of Applied Molecular Biology
ironmenta
・Department of Responses to Environmental
Signals and Stresses

Living organisms
ms

Human bbeingsGenes and cells

12Outline and Composition of Departments

DIVISION OF INTEGRATED LIFE SCIENCEThis division consists of 17 laboratories including five cooperativelaboratories one from Radiation Biology Center, two from Institute for Virus Research, and two from Institute of Integrated Cell-Material Sciences(iCeMS). Thirty-seven graduate students are accepted in the Master's
Program annually, and 17 in the Doctoral Program. In this division, education and research are focused on the elucidation of basic mechanisms
regulating the chromosome transmission, chromosome replication, RNAarchitecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development, developmental plasticity, bioconversion,and environmental adaptation. Experimental approaches are taken withmicroorganisms, plants, and animals. We pursue education and research
to elucidate the molecular aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanisms
D

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

NAKASEKO, Yukinobu■ Main theme

INOUE, Tan
SHIRAISHI, Hideaki
FUJITA, Yoshihiko■ Main theme

Main theme in this laboratory is the analysis of

Research in this laboratory focuses on Synthetic

eukaryotic cell cycle regulation. Especially, regulation

Biology of RNA and RNP (RNA-protein complex).

of chromosome separation and segregation during

Topics of interest include design and development

mitosis has been extensively studied. Fission yeastof new functional RNAs (RNPs), and RNAs (RNPs)-

Schizosaccharomyces pombe is used as a model

based synthetic genetic networks. The design andsystem. This yeast has all basic features involved indevelopment is performed based on the structure ofcell cycle regulation which are conserved among all

naturally occurring RNA molecules and also in vitro

eukaryotic cells. And wide variety of approach canand in vivo evolution technique.

be taken for analysis such as genetical, biochemical,

Also used for research in this laboratory is an edible

molecular biological technique. Identification offilamentous cyanobacterium, Arthrospira platensis,

individual genes involved in regulation of the celland a multicellular green alga, Volvox carteri. By

cycle is start point. Elucidation of whole net work ofusing these organisms, we are investigating growth,

the function of these genes is one of a goal in thisdevelopment and evolution of photosynthetic

research.

microorganisms.

http://kuchem.kyoto-u.ac.jp/seika/

14

DIVISION OF INTEGRATED LIFE SCIENCEDepartment of Celland Developmental Biology

Laboratory of Cell Cycle Regulation

Laboratory of Cell Recognition and
Pattern Formation■ Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

ISHIKAWA, Fuyuki
TARUMOTO, Yusuke■ Main theme

UEMURA, Tadashi
CHISAKA, Osamu
USUI, Tadao■ Main theme

Our research activity focuses on the molecular

We are investigating mechanisms that control

mechanism of the flow of genetic infor mation.

epithelial cell polarization and pattern formation of

Chromosomes, the vehicle of genetic materials,

neuronal dendrites and axons during development.

show both faithful and flexible behaviors, in different

The research subjects include: 1) To explore thetime scales, from a single round of the cell cycle tomolecular basis of development, regeneration, andthe evolution of species, and in different conditions,

life-long maintenance of neuronal dendritic trees. 2)

such as development, aging and cancer. TheseTo elucidate how cell-to-cell recognition contributes

apparently opposite behaviors of chromosomes canto planar cell polarity (PCP). 3) To reveal mechanisms

be explained by the need of genetic materials to beof controling cell migration in vertebrate embryos.

transmitted robustly. We are particularly interested

To conduct these studies, we employ a variety ofin how functional domains of chromosome, such as

molecular, cellular, genetic, and computationaltelomeres, are established and maintained, and how

approaches, and use Drosophila, vertebrates, andchromosomes respond to external stimuli, as exemplified

cell lines. Our long-term goal is to shed light onby the genetic instability found in cancer cells. We arepathogenesis of human diseases that are caused bytrying to understand these questions by experimental

defects in the epithelial or neuronal morphogenesis

approaches based on genetics, biochemistry, andand integrity.

molecular and cellular biology in various model systems,
such as fission yeast, Xenopus, and mammalian cells.
1) Closed

2) Semi-open

TelomeraseP3) Open

DNA damage
response

Telomeres consist of DNA ends and the shelterin protein
complex.
1) Long telomeres form a closed state competent toprotect telomere ends. 2) Moderately short telomeres
recruit telomerase to elongate telomere DNA. 3) Very short
telomeres are deprotected, activating the DNA damage
response. Phosphorylation of the shelterin protein regulatethese processes. Yamazaki et al. Genes & Dev. 26:241 (2012)
http://www.lif.kyoto-u.ac.jp/labs/fish/

http://www.lif.kyoto-u.ac.jp/labs/cellpattern/

DIVISION OF INTEGRATED LIFE SCIENCE

15

Division of Integrated
Life Science
Department of Plant Gene and Totipotency

Laboratory of Signal Transduction

Laboratory of Plant Molecular Biology■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Lecturer

NISHIDA, Eisuke
MIYATA, Yoshihiko
KUSAKABE, Morioh■ Main theme

KOHCHI, Takayuki
NISHIHAMA, Ryuichi■ Main theme

We are interested in identifying and elucidating

Research in this laboratory focuses on the adaptive

molecular mechanisms that regulate cell

regulation of growth and development to environmental

proliferation, cell differentiation, cell cycle, aging

conditions using model photosynthetic organisms.

and developmental processes. The current topics

Topics include mechanism of photomorphogenesis

include 1) regulatory mechanisms and functions ofand meristem development. We study molecular

the MAP kinase cascade pathways, 2) identification

mechanisms of light sensing by photoreceptors andof novel signal transduction mechanisms, 3) molecular

downstream genetic network of signal transduction.

mechanisms for life span regulation, 4) roles of protein

Approaches by molecular genetics and comparative

kinases in cell cycle progression and regulation, 5)

genomics are taken with Arabidopsis and liverwort

growth factor signaling mechanisms in developmental(Marchantia polymorpha). In particular, the genetic

processes, 6) regulatory mechanisms for mammaliananalysis of Marchantia is unique and efficient as its

circadian clock.

phylogenetically basal position in land plant evolution,
haploid-dominant life cycle, and simple transgenesis.
Genome analysis of Marchantia is also conducted in thislaboratory.

http://www.lif.kyoto-u.ac.jp/labs/signal/

16

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/plantmb/

Department of Applied Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency

Laboratory of Biosignals and Response■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

NAGAO, Masaya
KAMBE, Taiho
MIYAMAE, Yusaku■ Main theme

Molecular and cellular biological studies on

Bio-prospecting, a research strategy searching

totipotency in plant cells have been carried out in thisfor compounds that possess beneficial activity forlaboratory using in vitro cultured cells and transgenic

health from natural sources, is one of the projects inplants. Especially, cell/organ differentiation fromthis laboratory. Especially, at present, compounds thatundifferentiated cells, functional differentiations, e.g.

prevent hepatic fibrosis and replication of hepatitis C

oxygen evolving complex in photosystem II, cyclic

virus are the main targets of our bio-prospecting.

electron transfer and gene regulation in chloroplast,

We are also studying how organisms perceive

as well as molecular biology of secondary metabolism,

environmental signals and transduce these signals intosuch as biosynthesis of isoquinoline alkaloids in plantchanges in gene expression, focusing mainly on thecells have been investigated to understand themolecular and cellular basis of zinc metabolism (suchtotipotent functions in plant cells. Development

as uptake, storage, delivery, and maintenance ofof novel genetic engineering techniques such as

metal concentration in cells) in mammal.

differential RNAi, metabolic engineering and synthetic
biology of secondary metabolism for industrial
application have been also investigated.

Stimulation of lipid accumulation by plant extracts

Zinc transporters in mammals
ENTEROCYTE
ZnT4

Zn2+

ZIP4

GENERIC CELL

ZnT1

Zn2+

ZIP5

2+

Zn

ZnT1

Zn2+

ZnT2, 4

ZIP1~3, 6, 8, 10, 14

Zn

Endosomes/Lysosomes

2+

Zn2 +

ZIP7, 9, 13
MTF-1
ZnT1

Zn

ER/
Golgi

ZnT4~7
TGN

MT

2+

ZIP5
Mt-I/II, Znt1 etc

ACINAR CELL
Glutamate vesicles

2+

Zn

ZnT5, 8
ZIP3

ZnT3

ZIP4

ZnT2, 4Insulin granules

MAMMARY EPITHELIAL CELL

http://www.lif.kyoto-u.ac.jp/labs/callus/

β CELLNEURON

http://nucleus.lif.kyoto-u.ac.jp/labs/seitaijoho/

DIVISION OF INTEGRATED LIFE SCIENCE

17

Division of Integrated
Life Science

Laboratory of Applied Molecular Microbiology

Laboratory of Molecular Biology ofBioresponse■ Professor■ Assistant Professor■ Assistant Professor■ Associate Professor

FUKUZAWA, Hideya
YAMANO,Takashi
KAJIKAWA,Masataka■ Main theme

MASUDA, Seiji■ Main theme

We are focusing on the molecular bases of biologicalResearch in this laboratory focuses on thefunctions of microorganisms contributing to production

mechanism of RNA maturation in the nucleus

of food, energy and industrial materials, and also to

mediated by a number of proteins and small RNAs.

environmental remediation by photosynthesis. Especially

Messenger RNA is synthesized as pre-mRNA by RNA

we employ a green alga, Chlamydomonas reinhardtii,

polymerase II. Pre-mRNA undergoes the multiple

as a model eukaryotic photosynthetic microorganism

processing and become mature mRNA. Then, mRNA

using its genomic information, mutants, and molecular/

is exported to the cytosol to produce protein. During

biochemical techniques.

these processing, a large number of proteins are

The current projects are

conducted to process each step adequately. At(1) Molecular characterization of the carbon-concentratingpresent, we are focusing on the several projects tomechanism supporting photosynthetic carbon fixation,

understand the maturation and quality control of RNAs

energy production, and cell proliferation,in the nucleus. The main projects are (1) The role of(2) Elucidation of regulatory network systems controlling

TREX complex and the AREX complex, which couples

photosynthesis by sensing environmental factors includingtranscription and export of mRNA, (2) mRNA exportchanges of levels in CO2 concentration and light,

pathway in the mammalian cells and enhancing the(3) Metabolic engineering for production of poly-

protein production by optimizing the packaging andunsaturated fatty acid, polysaccharide, glycoprotein,export of mRNA and (3) the RNA quality control in theglycolipid and hydrocarbon,

nucleus to produce the adequately processed RNAs.

(4) Molecular control and signaling of sexual reproduction
by nutrient starvation.

                    



          

http://www.lif.kyoto-u.ac.jp/labs/molecule/18

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/bunshioutou/

Department of Responses to Environmental Signals and Stresses

Laboratory of Plant Developmental Biology

Laboratory of Plasma Membrane andNuclear Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

ARAKI, Takashi
ENDO, Motomu
YAMAGUCHI, Ayako■ Main theme

TAKEYASU, Kunio
YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

We are interested in molecular mechanisms

We are interested in how the cell signaling isunderlying plant’s responses to environment. Plants

regulated by specific molecular elements. By using a

have evolved plastic developmental programs withvariety of techniques in biochemistry, molecular andboth genetic and epigenetic basis to adapt theircell biology, and structural biology, we have been

sessile mode of life to changing environment. Using

investigating the structural and functional relationshipan angiosperm, Arabidopsis thaliana and a liverwort,

between the signaling elements (e.g., membrane

Marchantia polymorpha as model systems, we havereceptors and transcription factors) and their targets

been investigating (1) regulation of growth phase(e.g., specific enzymes and DNA). The current projects

transition (especially, flowering) and aging in response

deal with (1) higher-order architectures of prokaryotic

to environmental and endogenous signals, (2) long-and eukaryotic chromosomes, (2) transcriptional

distance systemic signaling in control of development,

regulation in the context of chromatin structure, (3)(3) tissue-specific roles of circadian clock for optimal

cross-talk between nuclear matrix and chromatin, andenvironmental responses, and (4) origin and evolution(4) molecular mechanism of macromolecular transportof regulatory systems for plastic development.

between cytoplasm and nucleus via nuclear porecomplex. The approaches to these problems include
single-molecule imaging and force measurement
using scanning probe microscopy, as well as generalbiochemistry and molecular biological techniques. This
consolidation should reveal a large part of the overall
picture of regulation of cell signaling in eukaryotes
and prokaryotes.

http://www.lif.kyoto-u.ac.jp/labs/plantdevbio/

http://www.lif.kyoto-u.ac.jp/labs/chrom/

DIVISION OF INTEGRATED LIFE SCIENCE

19

Division of Integrated
Life Science
Department of Molecular and Developmental Biology
D

Laboratory of Genome MaintenanceLaboratory of Nanobiology■ Professor■ Assistant Professor■ Professor

MATSUMOTO, Tomohiro
HABU, Toshiyuki■ Main theme

HARADA, Yoshie■ Main theme

The spindle checkpoint, our major research

We are developing novel single-molecule imaging

subject, is a surveillance mechanism to regulatetechniques to investigate dynamic processes

cellular apparatus for compliance with this rule. It is aof intracellular substances and DNA-protein

unique negative feedback that converts/amplifies ainteractions related to genome DNA maintenance.

physical signal sensed by kinetochores (attachment of

To characterize dynamic processes of DNA-protein

the spindle and/or tension) and regulates the timing

interactions, we are constructing Zero-modeof the sister chromatid separation. Mad2, a signal

waveguides. This method enables us to visualize

carrier of this feedback, plays a vital role in the spindle

single-molecule fluorescence at high concentration.

checkpoint. It is specifically localized at unattached

Using Zero-mode waveguides, we focus on

kinetochores that are the origin of the checkpoint

characterizations of proteins involved in homologous

signal. Mad2 targets CDC20 and inhibits its activity torecombination or epigenetics such as RuvAB protein

promote sister chromatid separation. We study Mad2,

complex or nucleosome binding proteins. We are alsoa central player of the spindle checkpoint, to reveal

developing a novel method for the selective imaging

mechanisms, which regulate the activity of Mad2.

using nanodiamonds. Using this novel method, westudy dynamic processes of intracellular substances ofinterest.

http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index.htm

20

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.harada.icems.kyoto-u.ac.jp/en/

Department of Molecular andCellular Biology

Laboratory of Developmental
Neurobiology

Laboratory of Molecular Cellular
Immunology■ Professor■ Professor■ Associate Professor

KENGAKU, Mineko■ Main theme

FUJITA, Takashi
KATO, Hiroki■ Main theme

Neurons in the mammalian brain are orderly

Virus infections, such as influenza A epidemic andarranged in cortices and nuclei for integration into

Chronic Hepatitis C virus infection are still important

specific neural circuits. During development, neurons

diseases and outbreaks of newly emerging viruses are

directionally migrate from the birthplace to theirserious problems for modern society. Higher animals,

destination within the cortex, and then arborize

including humans, are genetically equipped withwell-patterned dendrites and axons to contact

mechanisms, collectively known as innate immunity,with their specific synaptic counterparts. The major

to counteract viral infections. During the course ofgoal of our research is to clarity the mechanisms ofreplication, many viruses generate double-stranded

cortical lamination and functional wiring of neurons(ds) RNA, which is virtually absent in normal cells andin the brain. We seek to identify the molecularlikely serves as a "foreign molecule" in cells. An RNA

signals regulating neuronal migration and dendrite

helicase, RIG-I, functions as a sensor for viral dsRNA. RIG-I

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n g

is composed of three domains : a Caspase recruitment

techniques for real-time observation of molecular anddomain (CARD), a DExD/H helicase domain, and acellular dynamics of neuronal migration and dendrite

C-terminal domain (CTD) (Figure). CTD senses viral dsRNA

patterning to discover novel phenomena and rules in

produced in the cytoplasm, leading to a conformational

neuronal motility in the developing brain.

change. This conformational change releases CARD,
which signals to downstream, resulting in the activation

Molecular Layerof genes including those for type I interferon and other

Purkinje Cell Layer

cytokines. The purpose of our project is to clarify the

Granule Cell Layer

molecular mechanism underlying the antiviral innate

White Matter

Granule Cell

immunity regulated by RIG-I, and to develop new
diagnostic and therapeutic means for viral infections.
Purkinje Cell
Cerebellar nuclei

http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden2012/
http://www.kengaku.icems.kyoto-u.ac.jp/

English/index.html

DIVISION OF INTEGRATED LIFE SCIENCE

21

Division of Integrated
Life Science

Laboratory of Mammalian Molecular
Biology■ Associate Professor

TACHIBANA, Makoto■ Main theme
Our principal objective is to understand themolecular mechanism of epigenetic gene regulation
and roles of epigenetics in health and disease. We
also study how germ-lineage cell development inmammals is regulated. To address above questions,
we transgenic and gene-targeting technology.

http://www.virus.kyoto-u.ac.jp/Lab/mousemodel.htm

22

DIVISION OF INTEGRATED LIFE SCIENCEDIVISION OF SYSTE
SYSTEMIC LIFE SCIENCEThis division consists of 13 laboratories including 5 cooperative laboratories from Institute for Virus Research, Graduate School of Medicine,
Osaka Bioscience Institute, and RIKEN Center for Development Biology.
Thirty-eight graduate students are accepted in the Master's Program annually, and 16 in the Doctoral Program. In this division, education andresearch are focused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental
approaches are taken with viruses, microorganisms, cultured cells andanimals. We pursue education and research to elucidate
date the molecularmoleaspects of Systemic Life Science.

Division of SystemicLife Science
Department of Molecular and System Biology
D

Laboratory of Neuroscience

Laboratory of Bioimaging andCell Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Assistant Professor

WATANABE, Dai
ABE, Kentaro
MATSUI, Ryosuke■ Main theme

MATSUDA, Michiyuki
IMAJO, Masamichi■ Main theme

Research in this laboratory deals with molecular

We are visualizing the growth signal transduction

mechanisms underlying brain function andcascades in living cells by using biosensors based on

dysfunction. The main theme of research is the study

the principle of Foerster resonance energy transfer

of synaptic mechanisms responsible for memory and(FRET). These FRET videos are processed to extract

learning, motor movement and sensory perception.

parameters that characterize the property of each

The regulation and function of neurotransmitter

signaling molecule. We use these parameters

receptors and ion channels in synaptic transmission

obtained in living cells to build kinetic simulationand integration are extensively studied.

models of growth signal transduction cascades.We
are also developing transgenic mice expressing FRET
biosensors to observe the signaling status in living micewith two-photon excitation microscopes.

http://www.phy.med.kyoto-u.ac.jp/

24

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/Department of Animal Development and Physiology

Laboratory of Molecular andCellular Biology

Laboratory of Immunobiology■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

YONEHARA, Shin
SAKAMAKI, Kazuhiro
LEE, Kyung-Kwon■ Main theme

INABA, Kayo
TAKAHARA, Kazuhiko
IYODA, Tomonori■ Main theme

Apoptosis, or programmed cell death, plays an

Our interest is the induction and control ofimportant role in many biological processes, including

immunity and tolerance. We focus on dendritic cells

embryogenesis, development of immune system,(DCs), which are a primary antigen-presenting cell inmaintenance of tissue homeostasis, and elimination

the immune system. Studies have been conductedof virus-infected and tumor cells. We found cellat three levels: antigen uptake and presentation,

surface Fas antigen (Fas), which can directly mediate

surface molecules and cytokines that mediate cell-

apoptosis-inducing signals into cells by stimulation withcell interactions, and pathways for function in vivo.

agonistic anti-Fas mAbs or Fas ligand (Yonehara S, et

Our current major topics include the development ofal., 1989; Itoh N, et al., 1991). Our main research projectDCs from precursor cells, control of differentiation andis to understand the intracellular signal transduction

maturation of DCs, antigen handling mechanisms,

mechanism of cell death including apoptosis andmigratory characteristics from blood stream throughcaspase-independent novel types of cell death,

peripheral tissues to T area of lymphoid organs, andand the biological significance/physiological role ofactivation of antigen-specific CD4 and CD8 T cells.

cell death and cell death-regulating molecules. In

DCs have been applied clinically in immunotherapy

conjunction with these studies, we have been trying to

as nature's adjuvant to induce and amplify immune

identify other cell death-related molecules that play

responses. For better vaccine design, control of DC

a key role in embryogenesis, tumorigenesis or immune

function using molecular techniques to introduce

system. Investigations of molecular mechanisms andfunctional genes and molecules are also conducted.

physiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

http://www.lif.kyoto-u.ac.jp/labs/Fas/

http://zoo.zool.kyoto-u.ac.jp/imm/

DIVISION OF SYSTEMIC LIFE SCIENCE

25

Division of SystemicLife Science

Laboratory of Molecular Cell Biology andDevelopment（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Visiting Professor（Imai Laboratory）■ Visiting Associate Professor■ Main theme■ Main theme

IMAI, Takeshi

We seek to explore the molecular mechanisms

Neural circuit formation in vertebrates depends onunderlying the organization of cells into highly ordered

peripheral inputs to a certain extent. We are studying

structures in the developing brain. The vertebrate

how the neural circuits are constructed from peripherybrain comprises a considerably larger number ofto the central nervous system in a hierarchical manner.

neurons arranged in a vastly complex functional

We focus on the mouse olfactory system as a model

network, which develops from a single layer ofsystem. We are particularly interested in how the odorantepithelial cells that function as neural stem cells.

receptor control axonal projection of olfactory sensory

Those cells initially proliferate to expand the stem cell

neurons and how the peripheral inputs instruct specificpopulation. Subsequently neural stem cells undergo

neuronal circuits in the olfactory bulb. We are also trying

asymmetric cell divisions to generate self-renewing

the single-cell transcriptome analyses, in vivo imaging,and differentiating daughter cells. Thus the transitionand novel genetic tools to approach these issues.

from the proliferative phase to the neurogenic
phase is critical for the determination of the brain

Axonal projection of olfactory sensory neurons to
the olfactory bulb.

size. Asymmetric cell division also appears to play anessential role in the neuronal production. However,
little is known about mechanisms controlling thosecritical events in the brain development.
We use both an invertebrate (Drosophila) andvertebrate (mouse) model systems to understandprinciples for the brain organization such as:
1. How the timing of the proliferative to neurogenictransition is determined in the brain development.
2. How neural stem cells simultaneously generate
self-renewing and differentiating cells.
3. H o w c e l l p o l a r i t y c o n t r i b u t e s t o c o n t r o lasymmetric cell division of neural stem cells.
4. How diverse neuronal types are generated froma single neural stem cell over time.
5. How the global brain architecture is dictated by
the structure and activity of neural stem cells

http://www.cdb.riken.jp/en/02_research/0201_core07.html

26

DIVISION OF SYSTEMIC LIFE SCIENCE

http://imai.uijin.com/english.html

（Kitajima Laboratory）■ Visiting Associate Professor

KITAJIMA, Tomoya■ Main theme
In order to maintain genetic information acrossgenerations, cells must segregate chromosomes
equally to daughter cells during mitosis. Meiotic
divisions of the mammalian oocyte, however, are
known to exhibit a higher frequency of errors inchromosomal segregation than in other cell types.
Moreover, oocyte chromosomes behave in ways
distinct from those in other cells, and these uniquedynamics may provide insights into novel mechanisms
for chromosome segregation. Taking advantage of
our established live imaging technologies, we seek
to conduct detailed and comprehensive analysesof the chromosome dynamics and the molecularmachinery that underlies chromosome segregation
during mammalian oocyte meiosis. We also seek to
identify the causes behind age-related increases inchromosome segregation errors during oocyte meiosis.

（Kuranaga Laboratory）■ Visiting Associate Professor

KURANAGA, Erina■ Main theme
The development of multicellular organisms
involves the collective effect of multiple events at
the level of the individual cell, such as proliferation,differentiation, adhesion, and migration. Programmed
cell death, for example, is a process by which cells
are selected for death at set times in development,
allowing for the sculpting of tissue, and is used in theadult organism to maintain homeostasis by eliminating
cells that have developed abnormalities. Perturbations
in cell death signaling can thus affect an organism’s
physiological stability, and result in developmental
defects, tumorigenesis, or neurodegenerative disease.
Cell death plays an important role in maintaining thecellular society not only by eliminating unneeded
cells at given sites and stages, but in other functions,such as regulating the proliferation and migration ofneighboring cells, as well. Such cellular behaviors giverise to cell networks capable of organizing into tissues,
the study of which requires a experimental approachto spatiotemporal information in living systems, such as
can be obtained through the real-time live imaging of
biological phenomena.
We h a v e c h o s e n t h e f r u i t f l y D r o s o p h i l amelanogaster as our primary research model, seeking
to take advantage of its utility in developmental
studies and wealth of genetic data in studying
the coordination of morphogenesis through liveimaging and genetic screens. We especially focus
on the morphogenetic processes that involve cellularmigration and cell death, such as the looping
morphogenesis of fly male ter minalia and theabdominal epidermis rearrangement, to understandthe principles for the morphogenetic dynamics asfollows,
1) The physiological roles and regulating
mechanisms of cell death during development
2) Non-autonomous mechanisms to induce cell
death during regeneration
3) Mechanics and molecular mechanisms for
unidirectional motion of collective cellular movement
Figure: Caudal view of developing
fly male ter minalia expressing DECadherin:GFP

Prometaphase belt of chromosomes

http://www.cdb.riken.jp/en/02_research/0202_creative28.
html

http://www.cdb.riken.jp/en/02_
research/0202_creative27.html

DIVISION OF SYSTEMIC LIFE SCIENCE

27

Division of SystemicLife Science（Funabiki Laboratory）■ Visiting Associate Professor

FUNABIKI, Kazuo■ Main theme
We analyze neural circuits related to the reflexive
eye movements in mice. Reflexive eye movements aregood models to study neural mechanisms for motor
control and learning, because the inputs (vestibular,
visual stimuli) are precisely controlled and the outputs(eye movements) are quantitatively measured. In theneural circuits related to reflexive eye movements, we
focus on the cerebellar flocculus and the vestibular
nucleus. We record Purkinje cell response of thecerebellar flocculus in alert mice with simultaneousrecording of eye movements. Recently we developed
a fluorescence micro-endoscope which can observe
spatio-temporal pattern of neural activities in vivo. We
apply this endoscope for the analysis of cerebellar
granular layers in alert mice to elucidate neuralmechanisms for motor control and learning.

http://www.obi.or.jp/japanese/introduction/set_
systemsbiology.html

28

DIVISION OF SYSTEMIC LIFE SCIENCEDepartment of Signal Transductions

Laboratory of Molecular Neurobiology

Laboratory of Genetics■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Assistant Professor

NEGISHI, Manabu
KATOH, Hironori
OINUMA, Izumi■ Main theme
Outline of Teaching Activities

IGAKI, Tatsushi
NAITO, Yuko

■ Main theme
Our research focuses on the molecular basis of

The laboratory provides seminars which review andcell-cell communication that governs tissue growth,

discuss recent progress in molecular mechanisms of

homeostasis, and cancer. We take advantage of theneuronal functions

powerful genetics of Drosophila.

Outline of Research Activities
The main themes of research in this laboratory■ Research subjects:
1. Mechanism of cell competition

are the molecular mechanisms underlying neuronal

2. Genetic basis of tissue growth regulation

network formation and neuronal signal transductions.

3. Molecular basis of tumor progression and

1. Neuronal functions and signal transductions ofmetastasis

GTP-binding proteins
2. Molecular mechanisms for axon guidance
3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formation

Left:Polarity-deficient cells (green; losers) are eliminated from
epithelium by wild-type cells (magenta; winners) through cellcompetition.
Right:Malignant tumor cells (magenta) are invading andmetastasizing from the eye disc to the brain (blue) in Drosophila
larva.

http://www.lif.kyoto-u.ac.jp/labs/negishi/j/toppu.html

http://www.lif.kyoto-u.ac.jp/labs/genetics/

DIVISION OF SYSTEMIC LIFE SCIENCE

29

Division of SystemicLife Science
Department of Functional Biology

Department of Biostudies and Society

Laboratory of Functional Biology

Laboratory of Science Communication
and Bioethics■ Professor■ Lecturer■ Assistant Professor

KAKIZUKA, Akira
HORI, Seiji
OHIZUMI, Hiroshi■ Main theme■ Main theme

The major experimental themes being analyzed

In our laboratory, we aim to identify essential issues

in our laboratory are the following: (1) The molecularin the interface between biostudies and the society,and biochemical basis of cell deathand to propose possible actions or solutions.

The aim of this research is to understand themolecular mechanisms underlying carcinogenesis andneurodegeneration and to develop new strategies
for the treatment of cancers and neurodegenerative
disorders.

Currently, we are focusing on the following threeareas.
1.Theoretical and practical analysis of science
communication.
In addition to organizing practical activities such(2) The molecular basis of gene expression

as "Genome Square", a public event (http://hiroba.

networks determining energy expenditure and obesity

genome.ad.jp/ in Japanese language only), we

One of the main features of life science researchanalyze the effects and significance of sciencein the coming years will be that the results obtained

communication. This includes the communicationfrom fundamental research should ideally be

between scientists and the general public, and that

directly connected to thegood of society. From thisamong scientists and scientific communities.

standpoint, in addition to handling topics with high

2. Analysis of bioethical issues in biostudies.

scientific significance, we aim to contribute to the

We study ethical, legal and social implications ofdevelopment of treatments for neurodegenerative

biostudies such as human genome research anddiseases and cancers from our research results.
We hold the same view on scientific education,

human stem cell research.
3. Analysis of modern history of biostudies.

and through training individuals to communicate their

We analyze the development and changes ofideas logically yet effectively, as well as by nurturingbiostudies in the last 20 to 30 years through literature

their creativity, in addition to strengthening theirsurveys and interviews with scientists.

practical research skills, we aim to cultivate opinion
leaders standing at the core of life science research inthe 21st century.

http://www.lif.kyoto-u.ac.jp/labs/funcbiol/

30

DIVISION OF SYSTEMIC LIFE SCIENCEDepartment of Mammalian Regulatory Network

Laboratory of Cell Regulation and
Molecular Network

Laboratory of Viral Oncology■ Professor■ Professor■ Associate Professor■ Assistant Professor

SUGITA, Masahiko■ Main theme

TOMONAGA, Keizo
HIJIKATA, Makoto
HONDA, Tomoyuki■ Main theme

Full attention of the recently set up Sugita’s

The researches carried out in our laboratory arelaboratory has been directed to a novel lineage

focused on several RNA viruses, including bornavirus,of antigen-presenting molecules, CD1. Unlike

influenza virus and hepatitis C virus. All our projects

conventional MHC molecules that present protein-

aim to understand the fundamental mechanisms ofderived peptide antigens, molecules of thethe replication and pathogenesis of these viruses.

human group 1 CD1 family (CD1a, CD1b, CD1c)

We are investigating the replication and persistent

mediate presentation of lipid antigens to specificmechanism of the bornavirus in the cell nucleus.

T lymphocytes. By taking cell biological and

The understanding the biological significance of theimmunological approaches, this group wishes toendogenous element of bornaviruses in mammalianestablish a molecular and cellular basis for CD1-

genomes is one of the main focuses of bornavirus

dependent immunity and determine how CD1 hasresearches. We also aim to develop a novel RNA virus

been evolved to function critically in host defense.

vector using bornavirus, which can express stably

An important extension of this study is a challenge

functional small RNAs. In Influenza virus researches

for developing a new type of lipid-based vaccines

we examine the response of host cells to the virus

against cancer and microbial infection.

infection. The understanding of the molecularmechanism of tumorgenesis caused by hepatitis
C virus infection is also the main purpose of ourlaboratory.

http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

http://www.virus.kyoto-u.ac.jp/virus/ganvirus.html

DIVISION OF SYSTEMIC LIFE SCIENCE

31

Division of SystemicLife Science

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Assistant Professor■ Assistant Professor■ Professor

TOYOSHIMA, Fumiko
MATSUMURA, Shigeru
MAEKAWA, Momoko■ Main theme

SHIMIZU, Akira■ Main theme

Oriented cell division, which is determined by

Major goal of research in this laboratory is tothe axis of a mitotic spindle, plays an essential role

understand molecular and cellular mechanisms

in morphogenesis, asymmetric cell division and stem

underlying highly systemic functions of living things,

cell self-renewal. There is increasing evidence for thesuch as immune and neural systems. For this purpose,

implication of spindle misorientation in mammalianstructure and regulation of genetic informationdiseases, including tumorigenesis and polycystic

responsible for such systemic functions are being

kidneys. Our group seeks to explore the molecularanalyzed using model animals, for example,

mechanisms underlying the determination of celltransgenic or gene disrupted mice. Our research isdivision axis in both culture cells and in developing

focused on the following subjects:

mouse embryo. Our research is focused on thefollowing subjects:

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n dregulation of chromatin modification, gene
expression, gene rearrangements and RNA

1, Oriented cell division in culture cells and inmouse skin.

processing during lymphocyte differentiation.
2. Making and characterization of model mice

2, Cell division and differentiation of ES cells.

of immunodeficiency or autoimmune by

3, A role of lipid metabolites in the control of cell

introduction of, or targeted disruption ofdivision.
4, Control mechanisms for the membrane traffic
during mitosis.

interleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for
lymphocyte mobility and formation of immunomicroenvironment during development andimmune reaction.

http://www.virus.kyoto-u.ac.jp/Lab/toyoshima.html

32

DIVISION OF SYSTEMIC LIFE SCIENCEOrganization (2013)
DIVISION OF INTEGRATED LIFE SCIENCE
Department

Gene Mechanisms

Cell andDevelopmental Biology

Laboratory
Chromosome
Transmission
Gene Biodynamics
Cell Cycle Regulation
Cell Recognition and
Pattern Formation

Professor

Signal Transduction

NISHIDA,Eisuke

Associate Professor

Lecturer

Assistant Professor

NAKASEKO,Yukinobu
INOUE,Tan
ISHIKAWA,Fuyuki

SHIRAISHl,Hideaki

UEMURA,Tadashi

CHISAKA,Osamu

Plant Molecular Biology KOHCHl,Takayuki
Plant Gene andMolecular and Cellular
Totipotency
SATO,Fumihiko
Biology of Totipotency
Biosignals and
NAGAO,Masaya
Response
Applied Molecular
Applied Molecular
FUKUZAWA,Hideya
Microbiology
Biology
Molecular Biology ofBioresponse
Plant Developmental
ARAKI,Takashi
Responses to
Biology
Environmental Signals
Plasma Membrane
and Stresses
TAKEYASU,Kunio
and Nuclear Signaling
Genome
MATSUMOTO,Tomohiro
Maintenance1
Molecular andDevelopmental Biology Nanobiology2
HARADA,Yoshie*
Developmental
KENGAKU,Mineko
Neurobiology2
Molecular and Cellular
FUJITA,Takashi
3
Molecular and Cellular Immunology
Biology *Mammalian Molecular
Biology3

FUJITA,Yoshihiko
TARUMOTO,Yusuke
USUI,Tadao
HATTORI, Yukako
MIYATA,Yoshihiko
KUSAKABE,Morioh
NISHIHAMA,Ryuichi
ENDO,Tsuyoshi
IFUKU,Kentaro

KAMBE,Taiho

MIYAMAE,Yusaku
YAMANO,Takashi
KAJIKAWA,Masataka

MASUDA,Seiji
ENDO,Motomu
YAMAGUCHI,Ayako
YOSHIMURA,Shigehiro

KUMETA,Masahiro
HABU,Toshiyuki

KATO,Hiroki
TACHIBANA,Makoto*Cooperation Course 1) Radiation Biology Center, 2) Institute for Integrated Cell-Material Sciences (iCeMS), 3) Institute for Virus Research

DIVISION OF SYSTEMIC LIFE SCIENCE
Department

Laboratory

Professor

Neuroscience

WATANABE,Dai

Molecular and System
Biology
Bioimaging and Cell
MATSUDA,Michiyuki
Signaling
Molecular and Cellular
YONEHARA,Shin
Biology
Immunobiology
INABA,Kayo
Animal Development
and Physiology
Molecular Cell Biology
MATSUZAKI,Fumio6
and Development **Molecular
Neurobiology
Genetics
Functional Biology
Functional Biology
Science
Biostudies and Society Communication andBioethics
Cell Regulation and
Molecular Network4
4
Mammalian Regulatory Viral Oncology
Network *Cell Division and
Differentiation4
Genetic Information5
Signal Transductions

NEGISHl,Manabu

Associate Professo

Lecturer

Assistant Professor
ABE,Kentaro
MATSUI,Ryosuke
IMAJO,Masamichi

SAKAMAKl,Kazuhiro

LEE,Kyung-Kwon
TAKAHARA,Kazuhiko

IYODA,Tomonori

HORI,Seiji

NAITO,Yuko
OHIZUMl,Hiroshi

IMAI,Takeshi 6
KITAJIMA,Tomoya 6
KURANAGA,Erina 6
FUNABIKI,Kazuo 7
KATO,Hironori

IGAKI,Tatsushi
KAKIZUKA,Akira

OINUMA,Izumi

INABA,Kayo

SUGITA,Masahiko
TOMONAGA,Keizo

HIJIKATA,Makoto

TOYOSHIMA,Fumiko

HONDA,Tomoyuki
MATSUMURA,Shigeru
MAEKAWA,Momoko

SHIMIZU,Akira*Cooperation Course 4) Institute for Virus Research, 5) Graduate School of Medicine**Collaboration Course 6) RIKEN Center for Development Biology, 7) Osaka Bioscience Institute

Global Frontier in Life Science
Program-SpecificProfessor
HEJNA,James Alan

Organization33

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/access/getting/getting_1.htm

RIKEN Center for Developmental Biology▼Laboratory of Moleculer Cell Biology
and Development

KYOTO

Faculty of Medicine Bldg.F □SUITA

Laboratory of Bioimaging and Cell Signaling ▼KOBESouth Campus Research Building for □Integrated Life Sciences / Building G

OSAKA

Osaka Bio Institute▼Laboratory of Moleculer Cell Biology
and Development

Laboratory of Chromosome Transmission ▼Laboratory of Cell Cycle Regulation ▼Laboratory of Cell Recognition and ▼Pattern Formation
Laboratory of Plasma Membrane and ▼Nuclear Signaling
Laboratory of Molecular and Cellular Biology ▼Laboratory of Immunobiology ▼Laboratory of Molecular Neurobiology ▼Graduate School of Biostudies (Oﬃce) ▼to Kokusai kaikan

Kitaoji St.

Science Frontier Laboratory □Higashi-ichijo

Karasuma Imadegawa

Imadegawa St.

Kawaramachi St.

Karasuma St.

Horikawa St.

Radiation Biology Center □Kyoto Imperial Palace

Laboratory of Neuroscience ▼Laboratory of Functional Biology ▼Marutamachi St.

Laboratory of Genome Maintenance ▼Oike St.

Faculty of Pharmaceutical □Sciences Main Bldg.

Tozai Line

Shijo St.

Hankyu Ry.

to Osaka

Laboratory of Genetics ▼Gojo St.
Karasuma Line

Shitijo St.

1

Konoe St.

to Osaka

Kawabata St.

Marikoji St.

Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

Higashioji St.

※

Kyoto Sta.
Kintetu Line

to Nara□ Institute for Virus Research Main Bldg.
▼ Laboratory of Molecular and Cellular Immunology▼ Laboratory of Cell Regulationand Molecular Network▼ Laboratory of Cell Division and Diﬀerentiation□ Molecular Biology Research Bldg.
Faculty of Medicine Center for Genomic Med
Kasuga St.

34

Map & Access▼ Laboratory of Mammalian Molecular Biology▼ Laboratory of Viral Oncology▼ Laboratory of Genetic Information

North Campus Research Building □for Integrated Life Sciences
Laboratory of Gene Biodynamics ▼Laboratory of Plant Molecular Biology ▼Laboratory of Biosignals and Response ▼Laboratory of Applied ▼Molecular Microbiology
Laboratory of Molecular ▼Biology of Bioresponse
Laboratory of Plant ▼Developmental Biology
Laboratory of Science ▼Communication and Bioethics

Faculty of Agriculture (Main Bldg.) □Laboratory of Molecular and ▼Cellular Biology of Totipotency

Faculty of Science (Bldg. No.2) □Laboratory of Signal Transduction ▼to Kurama
Eizan Ry.

Ke

ifu

ku

Lin

e.

2

Mt. YoshidaaKonoe St.

Jingu Marutamachi Sta.

Shirakawa
Shi
a St.

Hyakumanben

Kyodai
Seimon-mae

Keihan Line

Kamo River

DemachiYanagi Sta.

St.
egawa

Imad

anben

to Hyakum

2
North Campus

Hyakumanben

3
1

Imadegawa St.

Sanjo Sta.
to Yamashina

Gion Shijo Sta.

Higashioji St.

N

JR Lineto Tokyoto Osaka

Higashi Ichijo St

Main Gate

Higashioji St.

□ Research Bldg. No. 1 / Project Lab.
▼ Program - Specific Professor
HEJNA, James Alan

□ Institute for Integrated
Cell - Material Sciences(iCeMS) Research Bldg.
▼ Laboratory of Developmental
Neurobiology▼ Laboratory of Nanobiology

icine

3
Konoe St.

Main Campus

Map & Access

35

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

kyomu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/