ඛ➃໬Ꮫ⏕࿨ᕤᏛ◊✲ D&<%(5 ࢭࣥࢱ࣮άືሗ࿌          aCYBER ࢭࣥࢱ࣮㛗 ⓑ▼ᾈᖹᡤဨ ᒣ⏣ᗣᯞ㸪Ώ㑓⩏அ㸪ᑠᕝᬛᘯ㸬ᖹᡂ  ᖺᗘάືሗ࿌ࣄࢺ⣽⬊ᰴࡢ฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲㸦ⓑ▼㸪ᒣ⏣㸧┠ⓗ!⣽⬊᥋╔ࢆไᚚࡍࡿ㧗ศᏊ⏕యᮦᩱ࠶ࡿ࠸ࡣᇶᯈ࡜ࡑࢀࡽ࡜ࣟ࣎ࢸ࢕ࢡࢫࢆ⼥ྜࡋࡓ㑇ఏᏊ㸪ࢱࣥࣃࢡ㉁ࡢ⥙⨶ⓗゎᯒ࠶ࡿ࠸ࡣ⣽⬊᧯స㸦ᅇ཰࣭⼥ྜ㸧ࢩࢫࢸ࣒ࡢᵓ⠏㸦ⓑ▼㸪ᒣ⏣㸧㸦⌧≧࡜⤖ᯝ㸧⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖ࡢ◊✲࡟࠾࠸࡚㸪⣽⬊ࢆ⏝࠸ࡓࣁ࢖ࢫ࣮ࣝࣉࢵࢺ࡞ᶵ⬟ゎᯒࡢࡓࡵࡢᇶᮦ㛤Ⓨ㸪ୗ㝈⮫⏺ඹ⁐ᗘᆺ㸪ୖ㝈⮫⏺ඹ⁐ᗘᆺᗘᛂ⟅ᛶ࣏࣐࣮ࣜࡢ㛤Ⓨ㸪㔠ࢫ࣏ࢵࢺ࡬ࡢ㑅ᢥⓗ࡞⣽⬊ࡢ᥋╔ࡀྍ⬟࡞⣽⬊࢔ࣞ࢖ࡢㄪ〇㸪⣽⬊᥋╔㡿ᇦ㸪㠀᥋╔㡿ᇦࡢᵓ⠏㸪⣽⬊᥋╔ᚋࡢ⣽⬊ᶵ⬟ࡢ᳨ウ㸪ࣄࢺேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ࢆᑟධࡍࡿ⣽⬊⼥ྜ⏝ᇶᯈ࡜ࣃࣝࢫ࣮ࣞࢨ࣮ග⣽⬊⼥ྜ㸪CW ࣮ࣞࢨ࣮ගࣆࣥࢭࢵࢺ㸪CW ࣮ࣞࢨ࣮ගຍ࡞࡝ࡍ࡭࡚㸪㡰ㄪ࡟㐍ࢇ࡛࠸ࡿ㸬ࡉࡽ࡟㸪࣮ࣞࢨ࣮࡟ࡼࡾ୙⏝࡞⣽⬊ࢆ㝖ࡃ࠶ࡿ࠸ࡣ᭷⏝⣽⬊ࡢࡳࢆ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰ࡍࡿࢩࢫࢸ࣒࠾ࡼࡧ⿦⨨ࢆ㛤Ⓨࡋ࡚࠸ࡿ㸬㸦◊✲ィ⏬㸧⣽⬊࢔ࣞ࢖ࢆ⏝࠸࡚᭷⏝⣽⬊࡜デ᩿ࡉࢀࡓ࢔ࣞ࢖ࢫ࣏ࢵࢺୖ࡟࣮ࣞࢨ࣮ග࡛ຍࡋ࡚⣽⬊ࢆ㑅ᢥⓗ࠿ࡘ㠀౵くⓗ࡟ࡣࡃ㞳ᅇ཰࡟ࢩࢫࢸ࣒㐍໬ࡉࡏ㸪ࡉࡽ࡟ຠ⋡ࡼࡃ⣽⬊᳨ฟ࣭ศูࡀฟ᮶ࡿ᮲௳ࢆ᳨ウࡋ࡚࠸ࡿ㸬⾲㠃࡟ฎ⌮ࡍࡿᶵ⬟ᛶ⣲ᮦࢆᗮ౯࡛ࡇࢀࡲ࡛ࡢྠࡌ࠶ࡿ࠸ࡣࡑࢀ௨ୖࡢᶵ⬟ࢆ㐩ᡂࡍࡿࡓࡵ࡟⣲ᮦࡢ᭱㐺໬ࢆ㐍ࡵ࡚࠸ࡿ㸬ࡲࡓ᧯సࡢ⮬ື໬ࢆど㔝࡟ධࢀࡓࣂ࢖࢜ࢳࣕࣥࣂ࣮ࢆྵࡴࣟ࣎ࢵࢺࡢస〇ࡶ㐍ࡵ㸪⣽⬊ᅇ཰ὶ㊰➼ࢆഛ࠼࡚⿦⨨ࢆస〇ࡋ࡚࠸ࡿ㸬࢚ࢫࢸࢵࢡᰴᘧ఍♫㸪㫽ྲྀ኱Ꮫ་Ꮫ㒊࡜࡜ࡗ࡜ࡾࣂ࢖࢜ࣇࣟࣥࢸ࢕࢔ࡢ࡛࣮ࣛ࣎ࣘࢨ࣮᝟ሗࢆྲྀࡾධࢀ࡞ࡀࡽ㛤Ⓨࢆ㐍ࡵࡿ㸬┠ⓗ!᪥ᮏ㓇ᡂศࡢ୰ࡢ᭷ຠᡂศࡢᵓ㐀Ỵᐃࢆ⾜࠸㸪ࢧࣉ࣓ࣜࣥࢺ㸪་⸆࡬ࡢᛂ⏝ࢆ᳨ウࡍࡿ㸬㸦ᒣ⏣㸧㸦⌧≧࡜⤖ᯝ㸧᪥ᮏ㓇ᡂศࡢศ⏬࡜࣓ࢱ࣮࣒࣎ࣟゎᯒࢆ⾜࠸㸪ࣄࢺࡢ╧╀ࡸᢠ୙Ᏻຠᯝ࡟㔜せ࡞ാࡁࢆࡋ࡚࠸ࡿ GABAA ཷᐜయάᛶཬࡧ NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟ᑐࡍࡿ᪥ᮏ㓇ᡂศࡢຠᯝࢆ᳨ウࡍࡿ㸬ཷᐜయࡢ㜼ᐖάᛶࡸసືάᛶࡀᚓࡽࢀࡓ≀㉁࡟ࡘ࠸࡚ࡑࡢຠᯝࢆヲ⣽࡟᳨ウࡋࡓ㸬GABAA ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 12 ᡂศぢฟࡋࡓ㸬ࡇࢀࡲ࡛㸪㙠㟼࣭ദ╀⸆㸪ᢠ②ᨥ⸆ࡸᢠ୙Ᏻ⸆ࡣ໬Ꮫ≀㉁࡛࠶ࡗࡓࡀ㸪௒ᅇぢࡘࡅࡓ≀㉁ࡣྂ᮶ࣄࢺࡀᦤྲྀࡋ࡚ࡁࡓ᪥ᮏ㓇࡟ྵࡲࢀࡿኳ↛ᡂศ࡛࠶ࡾ㸪⏕యෆ࡟ࡶᬑ㐢ⓗ࡟Ꮡᅾࡍࡿࡶࡢࡀከ࠸ࡓࡵ㸪⸆࡜ࡋ࡚ࡶᏳ඲ᛶࡀ㧗ࡃ㸪ࡲࡓᶵ⬟ᛶ㣗ရ࡬ࡢᛂ⏝ࡶྍ⬟࡛࠶ࡿ㸬ྠᵝࡢάᛶࡢ࠶ࡿ≀㉁ࡣࡇࢀࡲ࡛㸪ぢࡘ࠿ࡗ࡚࠾ࡽࡎ⌧ᅾㄽᩥసᡂ୰࡛࠶ࡿ㸦≉チฟ㢪୰㸧㸬
NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ࡟స⏝ࡍࡿ≀㉁ࢆ 6 ᡂศぢฟࡋ㸪ࡑࡢෆࡢ 3 ᡂศࡣ᪂つ≀－ 28 －

㉁࡛࠶ࡗࡓ㸬25 ᖺᗘ࢔࣓ࣜ࢝⚄⤒⛉Ꮫ఍࡟࡚ࡑࡢᡂᯝࢆⓎ⾲ࡋࡓ㸬㸦◊✲ィ⏬㸧௒ᚋࡶᘬࡁ⥆ࡁ㸪᪥ᮏ㓇࡟ྵࡲࢀࡿ᭷ຠᡂศࡢ⚄⤒⣔ཷᐜయ㸦GABAA ཷᐜయ㸪NMDA ᆺࢢࣝࢱ࣑ࣥ㓟ཷᐜయ㸧࡬ࡢຠᯝࢆ᳨ウࡍࡿ㸬ࡲࡓ㸪ࡑࡢ௚࡟ࡶ㸪࠾Ⲕ࡞࡝ࡢ᳜≀⏤᮶ࡢ㤶Ẽᡂศ㸪⏕⌮άᛶ≀㉁ࡢ⚄⤒⣔⣽⬊࡬ࡢຠᯝࢆ᳨ウࡍࡿ㸬┠ⓗ!⣽⬊ࢆ⏝࠸ࡓ་⸆ရ㸪ಖ೺ᶵ⬟㣗ရ࡬ࡢ㛤Ⓨࢆ┠ᣦࡋࡓ㓇ྵ᭷ᡂศ㸪࣌ࣉࢳࢻ㢮㸪ࣅࢱ࣑ࣥ㸪₎᪉ᡂศ࡞࡝⏕⌮άᛶ≀㉁ࡢ᳨⣴㸦⌧≧࡜⤖ᯝ㸧ࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪ࣉ࣏ࣟࣜࢫࡸࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥ㸪ከ⢾㢮ࡢຠᯝࢆ᳨ウࡋࡓ㸬ࣆࣟࣟ࢟ࣀࣜࣥ࢟ࣀࣥཬࡧࣉ࣏ࣟࣜࢫ࡟⚄⤒ẘཬࡧ㓟໬ࢫࢺࣞࢫ࡟ᑐࡍࡿಖㆤస⏝ࡀ࠶ࡿࡇ࡜ࢆぢฟࡋࡓ㸬㸦◊✲ィ⏬㸧௒ᚋࡶࣄࢺ⚄⤒ⱆ⣽⬊⭘⏤᮶ᰴࡸ⫢࢞ࣥ⏤᮶ᰴࢆ⏝࠸࡚㸪⣽⬊ಖㆤస⏝ࢆࡶࡘ≀㉁ࢆぢࡘࡅ㸪ࡑࡢస⏝ᶵᗎࢆ᳨ウࡍࡿணᐃ࡛࠶ࡿ㸬ࣂ࢖࢜ࣉࣛࢫࢳࢵࢡࢆ⏝࠸ࡿ࣮࢝࣎ࣥࢽ࣮ࣗࢺࣛࣝ⏘ᴗ⏝⣲ᮦࡢ㛤Ⓨ㸦ⓑ▼㸪ᒣ⏣㸧┠ⓗ!᳜≀⏤᮶⣲ᮦ࣏ࣜங㓟(PLA)࠶ࡿ࠸ࡣኳ↛ࢦ࣒(NR)ࢆ୺ᡂศ࡜ࡋࡓ㧗᳜≀ᗘ࡞⏘ᴗ⏝ᶞ⬡࠶ࡿ࠸ࡣࢦ࣒⣲ᮦࡢ㛤Ⓨ㸦ⓑ▼㸧㸦⌧≧࡜⤖ᯝ㸧᪂つ࡞⤖ᬗ໬ಁ㐍๣࡜ࡋ࡚ࡢ↓ᶵᮦᩱ➼ࡢ㑅ᐃ࡜㓄ྜᢏ⾡࡟ࡼࡾ㸪Ᏻ౯࡛࠿ࡘᑡ㔞ῧຍ࡛ PLA ࡢ≀ᛶᨵၿࡋࡓ㸬NR ࡟▼Ἔ⏤᮶ࡢ࣮࢝࣎ࣥࣈࣛࢵࢡ௦᭰࡜ࡋ࡚ࡢࢭ࣮ࣝࣟࢫࢼࣀࣇ࢓࢖ࣂ࣮(CNF)➼ࡢ㓄ྜ࡟ࡼࡗ࡚㸪⮬ື㌴⏝࢚࢘ࢨ࣮ࢫࢺࣜࢵࣉ࡜ࡋ࡚ᚲせ࡞ࢦ࣒≀ᛶࢆ㐩ᡂࡋࡓ㸬ᚓࡽࢀࡓᶞ⬡࠾ࡼࡧࢦ࣒⣲ᮦ࠿ࡽࡢ᥹Ⓨᛶ᭷ᶵ໬ྜ≀(VOCs)ࡢ⣽⬊➼ࢆ⏝࠸ࡿ᪂ࡋ࠸ホ౯ἲࢆ㛤Ⓨࡋ㸪PLA ୺ᡂศ࠿ࡽࡢ VOCs ࡢ୍㒊ࡀ⏕య࡟ᑐࡋ࡚ࡢᏳ඲ᛶࡀ㧗࠸ࡇ࡜ࢆㄆࡵࡓ㸬
PLA ࡢ♧ࡍඃࢀࡓὶືᛶ࡜◊✲㛤Ⓨ࡟ࡼࡗ࡚ᚓࡓῧຍ๣࡟ࡼࡿ≀ᛶㄪᩚᢏ⾡ࢆ⏝࠸࡚㸪⢭⣽ຍᕤရ⏝㏵࡜ࡋ࡚㸪་⒪⏝㏵ࡢ⾑ᾮ᥇ྲྀ↓③㔪⏝ࡢ⣲ᮦࡸ 3D ࣉࣜࣥࢱ࣮⏝ࡢᶞ⬡࡜ࡋ࡚ࡢᛂ⏝ᒎ㛤࡟╔ᡭࡋࡓ㸬ࡲࡓ㸪PLA ࡢ㓄ྜᨵ㉁࡟⏕య↓ẘ࡞ TiO2 ࢼࣀᚤ⢏Ꮚ㸦ࢫ࣏ࣥࢪ≧㓟໬ࢳࢱࣥ㸧ࢆά⏝ࡋ࡚㸪PLA ࡬ࡢ㓄ྜ࡟ࡼࡗ࡚ᶞ⬡ࡢຍᕤ᫬࡜ࡢὶືᛶࡸ≀ᛶᨵኚ࡟᭷ຠ࡛࠶ࡿࡇ࡜ࢆㄆࡵࡓ㸬㸦◊✲ィ⏬㸧⮬ື㌴⏝➼ࡢ⏘ᴗ⏝㏵࡛ࡣ㛤Ⓨ࠿ࡽ࣮ࣘࢨ࣮ࡢせồ࡟࠶ࡗࡓ௙ᵝ࡟᭱㐺࡞㓄ྜࢆ⾜࠸㸪ప౯᱁㸪Ᏻ඲㸪᫆ຍᕤᛶࡢᐇ⏝໬⣲ᮦ࡬࡜ࢩࣇࢺࡋࡓ஦ᴗ໬᳨ウࢆຍ㏿ࡍࡿ㸬⏕ศゎᛶᶵ⬟ࢆ฼⏝ࡋࡓ᪂つ࡞࣮ࣘࢨ࣮㛤ᣅࢆ㐍ࡵ᥇⾑⏝↓③㔪➼ࡢ་⒪⏝ᮦᩱ࡬ࡢᒎ㛤ࢆᶞ⬡ຍᕤᢏ⾡ࡢ㛤Ⓨࢆྠ࣓࣮࣮࢝㸦⚄ᡞᕷ㸪ᮾ኱㜰ᕷ㸧➼࡜ඹྠ࡛㐍ࡵࡿ㸬ᶞ⬡㸪ࢦ࣒ᡂศ࠿ࡽࡢ VOCs ࡢ⏕యᙳ㡪ࢆᘬࡁ⥆ࡁホ౯ࡍࡿ㸬⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢຠᯝⓗ࡞฼⏝ࢆᇶ♏࡜ࡋࡓ◊✲㸦Ώ㑓㸧┠ⓗ!ᆅᇦ࡛≉⏘ࡉࢀࡿ㎰Ỉ⏘≀㸪≉࡟ᮍ฼⏝࡞⏕≀㈨※ࡢ㣗ရ⣲ᮦ࡜ࡋ࡚ࡢᶵ⬟ࡢ௜ຍ㸪－ 29 －ྥୖ࠾ࡼࡧᨵኚࢆᐇ⌧ࡍࡿࡓࡵࡢ⏕≀໬ᏛᕤᏛⓗࣉࣟࢭࢫࡢᵓ⠏㸦⌧≧࡜⤖ᯝ㸧ࣞࣔࣥᯝ⓶ࢆ⏝࠸ࡓ࢔ࣝࢥ࣮ࣝ㣧ᩱ〇㐀࡟࠾ࡅࡿ⢾໬㐣⛬࡛ࡢᢠ㓟໬⬟ࡢ⤒᫬ኚ໬ࡀホ౯ࡉࢀࡓ㸬〇㐀ࣉࣟࢭࢫ࡟࠾ࡅࡿᮦᩱࡢᶵ⬟ᛶኚ໬࡟㛵ࢃࡿ㔜せ࡞▱ぢࡀᚓࡽࢀࡓ㸬ࡲࡓ㸪ฟỒసࡾ࡟୍⯡ⓗ࡟౑⏝ࡉࢀ࡚࠸ࡿ᪻ᕸ㸪㫎⠇࠾ࡼࡧ⅗ࡾᏊࢆཎᩱ࡜ࡋࡓ᭱㐺࡞ㄪ〇᮲௳࡜㸪ࡑࡢ㝿ࡢ᪨࿡ᡂศ㔞ࡸ⢓ᛶ࣭Ⰽㄪ࡞࡝ࡢ≧ែࡀ☜ㄆࡉࢀࡓ㸬ᚑ᮶ࡢᡭἲࡀ᭱ࡶຠᯝⓗ࡟᪨࿡ᡂศࢆᢳฟ࡛ࡁࡿࡇ࡜ࡀᐃ㔞ⓗ࡟♧ࡉࢀࡓ㸬㸦◊✲ィ⏬㸧⢾໬ᕤ⛬ᚋࡢຠ⋡ⓗ࡞Ⓨ㓝᮲௳ࡢ᳨ウ࡜㸪᪂つ࡞࢔ࣝࢥ࣮ࣝ㣧ᩱ㛤Ⓨࡢࡓࡵࡢ࠾࠸ࡋࡉ࡟㓄៖ࡋࡓⓎ㓝⿵ຓᮦᩱࡢ฼⏝࡟ࡘ࠸᳨࡚ウࡍࡿ㸬ࡲࡓ㸪ᆅᇦࡢ≉⏘ရࢆ⏝࠸ࡓฟỒㄪ〇ࡢ㝿ࡢ᪨࿡ᡂศ࠾ࡼࡧ㤶Ẽᡂศ㔞ࡢᐃࡸ㸪Ⰽㄪ࠾ࡼࡧ⢓ᛶ࡞࡝ࡢ≧ែほᐹࢆㄢ㢟࡜ࡋ࡚ྲྀࡾ⤌ࡴ㸬᪂ࡋ࠸ฟỒ࡟࠾ࡅࡿ࠾࠸ࡋࡉ๰㐀ࡢࡓࡵࡢ⛉Ꮫⓗ᰿ᣐࢆᥦ♧ࡍࡿࡇ࡜ࢆ┠ᣦࡍ㸬⫢⮚⑓ែࡢస⏝ᶵᗎࡢゎ᫂࡜⫢⮚࡟ᑐࡍࡿᢠ㓟໬≀㉁ࡢస⏝࡟㛵ࡍࡿ◊✲㸦ᑠᕝ㸧┠ⓗ!࠶ࡽࡺࡿ⫢⮚⑓ࡢస⏝ᶵᗎࢆ᫂ࡽ࠿࡟ࡍࡿ࡜࡜ࡶ࡟㸪་⸆ရࡸ㣗ရ࡟ྵࡲࢀࡿᡂศࡢᏳ඲ᛶࡢ᳨ウ࠾ࡼࡧ᪂ࡓ࡞⏕⌮άᛶ≀㉁ࡢⓎぢ㸦ᑠᕝ㸧㸦⌧≧࡜⤖ᯝ㸧࣐࢘ࢫࡢ⫢⮚⑓ែࣔࢹࣝࢆస〇ࡋ㸪ࡑࡢ࣐࢘ࢫ࡟ᙉ࠸ᢠ㓟໬స⏝ࢆᣢࡘࣉ࣏ࣟࣜࢫࢆᢞ୚ࡍࡿࡇ࡜࡛⫢⮚ࡢ⬡⫫໬ࡸ⅖⑕㸪⥺⥔໬࡬ࡢᙳ㡪ࢆ㑇ఏᏊ࠾ࡼࡧࢱࣥࣃࢡ㉁ࣞ࣋ࣝ
࡛ࡢゎᯒࢆ⾜ࡗࡓ㸬ࡲࡓ㸪⫢⮚⣽⬊㸦⫢ࡀࢇ⣽⬊ࡸᫍ⣽⬊㸧࡟ࣉ࣏ࣟࣜࢫᡂศࢆῧຍࡍࡿࡇ࡜࡟ࡼࡿ⣽⬊ࡢቑṪࡸ㑇ఏᏊ࠾ࡼࡧࢱࣥࣃࢡ㉁ࡢⓎ⌧ࢆㄪ࡭ࡓ㸬⤖ᯝ࡜ࡋ࡚㸪ࣉ࣏ࣟࣜࢫᢞ୚࡟ࡼࡗ࡚࣐࢘ࢫ⫢⮚ࡢ⬡⫫໬ࡸ⥺⥔໬ࡀᢚไࡉࢀࡓ㸬ࡲࡓ㸪ࣉ࣏ࣟࣜࢫᡂศࡢ୰࠿ࡽᫍ⣽⬊ࡢቑṪ࠾ࡼࡧࢥ࣮ࣛࢤࣥ⏘⏕ࢆᢚไࡍࡿᡂศࡢྠᐃ࡟ᡂຌࡋࡓ㸬㸦◊✲ィ⏬㸧ᘬࡁ⥆ࡁୖグࡢヲ⣽࡞ᐇ㦂ࢆ⾜࠸㸪ࣉ࣏ࣟࣜࢫࡢ⫢⮚ࡢ⬡⫫໬ࡸ⅖⑕㸪⥺⥔໬㸪㓟໬ࢫࢺࣞࢫࡢ࡬ࡢᙳ㡪ࢆㄪ࡭ࡿ㸬ࡲࡓ㸪ᫍ⣽⬊ࡢቑṪࡸࢥ࣮ࣛࢤࣥ⏘⏕ࢆᢚไࡍࡿࣉ࣏ࣟࣜࢫᡂศࡢ⫢⮚⑓ែ࡛ࡢᶵ⬟࡟ࡘ࠸࡚ゎᯒࢆ⾜࠺㸬ඹྠ◊✲௳ 1)ⓑ▼ᾈᖹ㸸ᖹᡂ 25 ᖺᗘ  ࠕࢼࣀࣇ࢓࢖ࣂ࣮໬ࣂ࢖࣐࢜ࢫཎᩱࡢኳ↛ࢦ࣒୰࡛ࡢ⏺㠃⤖ྜ࡟㛵ࡍࡿ◊✲ࠖ㸪 ⊂ ⏘ᴗᢏ⾡⥲ྜ◊✲ᡤ࡜ࡢඹྠ◊✲2)ⓑ▼ᾈᖹ㸸ᖹᡂ 25 ᖺᗘ㸦2 ௳㸧3)ᒣ⏣ᗣᯞᖹᡂ 25 ᖺᗘࠕࢢࣝࢱ࣑ࣥ㓟ཷᐜయཬࡧ GABA ཷᐜయ࡟స⏝ࡍࡿ㓇ᡂศ࡟㛵ࡍࡿ◊✲ࠖ㸪 ⊂ 㓇㢮⥲ྜ◊✲ᡤ4)ᒣ⏣ᗣᯞ㸸ᖹᡂ 25 ᖺᗘࠕ⚄⤒⣽⬊࠾ࡼࡧ⚄⤒⣔ཷᐜయ࡟ᑐࡍࡿࢧࣜࣥ㢮ఝ໬ྜ≀ࢆ୺࡜ࡋࡓ⸆ẘ≀ࡢస⏝ࠖ㸪ᅜ❧኱Ꮫἲேᗈᓥ኱Ꮫ኱Ꮫ㝔་ṑ⸆ಖ೺Ꮫ◊✲⛉－ 30 －5) ᒣ⏣ᗣᯞ㸸ᖹᡂ 25 ᖺᗘࠕᲬⲔ࡟ྵࡲࢀࡿ㤶Ẽᡂศࡢࣜࣛࢵࢡࢫຠᯝࡢホ౯ࠖ㸪▼ᕝ┴ᕤᴗヨ㦂ሙ6)Ώ㑓⩏அ㸸ᖹᡂ 24 ᗘ㹼ᖹᡂ 25 ᖺᗘ  ࠕங໬ཬࡧ⢊ᮎ໬᧯స࡟ࡼࡿࢼࣀᵓ㐀໬ᶵ⬟ᛶ⬡㉁⢊ᮎࡢ㓝⣲ฎ⌮ᢏἲ㛤Ⓨࠖ᪥ᮏᏛ⾡᣺⯆఍᪥ᮏࣇ࢕ࣥࣛࣥࢻ஧ᅜ㛫ඹྠ◊✲㸪㤶ᕝ኱Ꮫ㸪ி㒔኱Ꮫ㸪ᒸᒣ኱Ꮫ㸪ࣇ࢕ࣥࣛࣥࢻᅜ❧ᢏ⾡◊✲ᡤ࡜ࡢඹྠ◊✲㸬୺せ࡞◊✲ᴗ⦼  ㄽᩥ  ௳ 1)ⓑ▼ ᾈᖹ㸪▮㔝 ᚭ㸪୕⏣ ᾈ㈗㸪㐲⸨ ㈗ኈ㸪͆ᮌ㉁ࢭ࣮ࣝࣟࢫࢼࣀࣇ࢓࢖ࣂ࣮㓄ྜ࡟ࡼ ࡿ ኳ ↛ ࢦ ࣒ ࡢ ≀ ᛶ ᨵ ၿ ” 㸪 ㏆ ␥ ኱ Ꮫ ḟ ୡ ௦ ᇶ ┙ ᢏ ⾡ ◊ ✲ ᡤ ሗ ࿌ 㸪 Vol.4, (2013),pp.43-472)

௒ᇛ ᫂඾㸪ఀ⸨ ኱᫬㸪㎰᐀ ㎮ᕫ㸪ᮅ஭ 㯞ዉே㸪ⓑ▼ ᾈᖹ㸪͆⾲㠃㛤ጞ ATRP ἲ࡟ࡼࡾ LCST ᆺᗘᛂ⟅ᛶ㧗ศᏊࢆಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ HeLa ⣽⬊ࡢᗘ่⃭ࡣࡃ㞳”㸪㏆␥኱ᏛᕤᏛ㒊◊✲ሗ࿌㸪Vol.47, (2013) , pp.7-123)ⓑ▼ ᾈᖹ㸪┦Ⰻ ᐀స㸪▮㔝 ᚭ㸪ᕝཱྀ ᩗᏊ㸪ᶫᮏ 㑥ᙪ㸪࣏͆ࣜங㓟ᑕฟᡂᙧ࡟ࡼࡿ⮬ື㌴ෆ⿦⏝ࣔࢪ࣮ࣗࣝ㒊ရࡢ᪂つ㛤Ⓨ”, ᶵ⬟ᮦᩱ, Vol.33(8), (2013) , pp.36-414)

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6)

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K, Nomura M, “Changes in the Composition of Saccharides in Rice Grains throughCooking and Digestion using Synthetic Human Saliva” ,In Recent Advances inGinseng and Glycosides Research (Eds., Hopkins C J, Nova Science Publishers),(2013),pp. 137-154

  Ꮫ఍Ⓨ⾲  ௳ 1)ఀ⸨኱᫬㸪㎰᐀㎮ᕫ㸪ᒣ⏣ᗣᯞ㸪ⓑ▼ᾈᖹ㸪ᮡᒣ୍⏨㸪Ἑ⃽༤ᩥ㸪͆UCST ᆺᗘᛂ⟅ᛶ࣏࣐࣮ࣜࢆ⾲㠃ಟ㣭ࡋࡓᇶᯈࡢㄪ〇࡜⇕࣭࣮ࣞࢨ࣮ග↷ᑕ࡟ࡼࡿ⣽⬊ࡣࡃ㞳ࡢホ౯͇➨ 62 ᅇ㧗ศᏊᏛ఍ᖺḟ኱఍㸦ி㒔㸧㸪(2014) 2)௒ᇛ᫂඾㸪ᒣ⏣ᗣᯞ㸪ⓑ▼ᾈᖹ㸪ᮡᒣ୍⏨㸪୰㇂㐩⾜㸪͆⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖࡟ࡼࡿ U937 ⣽⬊࡜ࣄࢺேᕤᰁⰍయ(HAC)࣋ࢡࢱ࣮ྵ᭷ᚤᑠ᰾⣽⬊ࡢ㧗ຠ⋡⼥ྜ͇➨ 62ᅇ㧗ศᏊᏛ఍ᖺḟ኱఍㸦ி㒔㸧㸪(2014) 3)ఀ⸨኱᫬㸪㎰᐀㎮ᕫ㸪ᒣ⏣ᗣᯞ㸪ⓑ▼ᾈᖹ㸪Ἑ⃽༤ᩥ㸪୰㇂㐩⾜㸪͆ST-ATRP ἲ4)

࡟ࡼࡾ UCST ᆺᗘᛂ⟅ᛶ Poly (acrylamide-co-acrylonitrile) ࢆ⾲㠃ಟ㣭ࡋࡓ࢞ࣛࢫᇶᯈࡢㄪ〇࡜ຍ࡟ࡼࡿ⣽⬊ࡣࡃ㞳͇㸪➨ 62 ᅇ㧗ศᏊウㄽ఍㸦㔠ἑ㸧㸪(2014) ௒ᇛ᫂඾㸪ᮅ஭㯞ዉே㸪ᒣ⏣ᗣᯞ㸪ⓑ▼ᾈᖹ㸪୰㇂㐩⾜㸪͆ST-ATRP ἲ࡟ࡼࡾ－ 31 －

PNiPAAm 㙐㛗ࢆไᚚࡋࡓᅛᐃ໬࢞ࣛࢫᇶᯈࡢㄪ〇࡜㛫ⴥ⣔ᖿ⣽⬊(MSC)ࡢ᥋╔࠾ࡼࡧࡣࡃ㞳͇㸪➨ 62 ᅇ㧗ศᏊウㄽ఍㸦㔠ἑ㸧㸪(2014) 5)୰㊰ᫀྖ㸪ᑠᕝᬛᘯ㸪⸨ཎᘯᐅ㸪ᒣ⏣ᗣᯞ㸪͆ࣄࢺ⚄⤒ⱆ⣽⬊⭘ᰴ SK-N-SH ࡢ
6-OHDA ࠾ࡼࡧ㐣㓟໬Ỉ⣲࡟ࡼࡿ⣽⬊Ṛ࡟ಖㆤຠᯝࢆ♧ࡍ≀㉁ࡢ᳨ウ͇㸪᪥ᮏ㎰ⱁ໬Ꮫ
఍ 2014 ᖺᗘ኱఍㸦ᮾி㸧㸪(2014) 6)ᑠᕝᬛᘯ㸪ᒣ⏣ᗣᯞ㸪රᗜ⚽ᖾ㸪Ἑ⏣๎ᩥ㸪͆The beneficial effect of propolis on fataccumulation and lipid metabolism in NASH model”㸪Asian Pacific Association fortheStudy of the Liver 2014(Australia)㸪(2014)7)ᑠᕝᬛᘯ㸪ᒣ⏣ᗣᯞ㸪රᗜ⚽ᖾ㸪Ἑ⏣๎ᩥ㸪͆ࣉ࣏ࣟࣜࢫࡢ⬡⫫⫢ࡸ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖(NASH)ᑐࡍࡿண㜵࠾ࡼࡧ἞⒪ຠᯝࡢ᳨ウ͇㸪➨ 40 ᅇ᪥ᮏ⫢⮚Ꮫ఍す㒊఍㸦ᒱ㜧㸧㸪(2013)
8)ᑠᕝᬛᘯ㸪ᒣ⏣ᗣᯞ㸪රᗜ⚽ᖾ㸪Ἑ⏣๎ᩥ㸪͆The beneficial effect of propolis on fat
accumulation and liver fibrosis in mice fed a methionine-choline diet.” 㸪 17thInternational Symposium on Cells of the Hepatic Sinusoid㸦኱㜰㸧㸪(2013) 9)⸨஭ⱥᶞ㸪ᑠᕝᬛᘯ㸪ඖᒣᏹ⾜㸪ྜྷ㔛຾฼㸪Ἑ⏣๎ᩥ㸪“Role of macrophagescavenger receptor A in hepatic fibrogenesis of an animal NASH model”㸪17thInternational Symposium on Cells of the Hepatic Sinusoid㸦኱㜰㸧㸪(2013) 10)ᑠᕝᬛᘯ㸪͆ᩍ⫋ㄢ⛬⛉┠࡟࠾ࡅࡿ iPad ᑟධ࡟ࡼࡿ⌮⛉ᤵᴗࡢᐇ㊶࡜ࡑࡢホ౯͇㸪᪥ᮏᕤᏛᩍ⫱༠఍➨ 61 ᅇᖺḟ኱఍㸦᪂₲㸧㸪(2013)
11)୰㊰ᫀྖ㸪ᑠᕝᬛᘯ㸪⸨ཎᘯᐅ㸪ᒣ⏣ᗣᯞ㸪͆ࣄࢺ⚄⤒ⱆ⣽⬊⭘ᰴ SK-N-SH ࡟ᑐࡍࡿ㓟໬ࢫࢺࣞࢫಖㆤຠᯝ͇㸪᪥ᮏ㎰ⱁ໬Ꮫ఍୰ᅄᅜᨭ㒊➨ 36 ᅇㅮ₇఍㸦ᓥ᰿㸧㸪(2013)
12) Y. Yamada, K. Norikane, K. Matsumaru H. Izu, ͆ Effects of polyamines andmonoamines on GluN1/GluN2A and GluN1/GluN2B subtypes of NMDA receptor
Neuroscience” (San Diego), (2013 November 9-13)
13)୰ᮧ୍⨾㸪ᶞ㔝῟ஓ㸪⡿ཎ∾Ꮚ㸪ᒣ⏣ᗣᯞ㸪➉ཎఙ㸪͆㌴ᐊෆ✵㛫ࡢᛌ㐺ᛶྥୖࢆ┠ᣦࡋ࡚͇㸪⏕ά⏕࿨ᨭ᥼་⒪⚟♴ᕤᏛ⣔Ꮫ఍㐃ྜ኱఍ (LIFE2013)㸦ᒣ᲍㸧㸪(2013) 14)୰ᮧ୍⨾㸪ᶞ㔝῟ஓ㸪⡿ཎ∾Ꮚ㸪ᒣ⏣ᗣᯞ㸪➉ཎఙ㸪͆⮬ື㌴ᐊෆࡢᛌ㐺ᛶ࣭✵Ẽ㉁࡟㛵ࡍࡿᇶ♏◊✲͇㸪➨15ᅇ ᪥ᮏឤᛶᕤᏛ఍㸦ᮾி㸧㸪(2013) 15) ᒣ⏣ᗣᯞ㸪኱㇂⯟ᖹ㸪ⓑ▼ᾈᖹ㸪͆᥹Ⓨᛶ᭷ᶵ໬ྜ≀ࡢ⚄⤒⣔⣽⬊࡬ࡢຠᯝ͇㸪➨
40 ᅇ ᪥ᮏẘᛶᏛ఍Ꮫ⾡ᖺ఍㸦༓ⴥ㸧㸪(2013)
16)୰ᮧ୍⨾㸪ᶞ㔝῟ஓ㸪⡿ཎ∾Ꮚ㸪➉ཎఙ㸪ᒣ⏣ᗣᯞ㸪͆ᝏ⮯≀㉁ࡀ࣐࢘ࢫࡢ⮬Ⓨ㐠ື⬟࡟࠾ࡼࡰࡍᙳ㡪͇㸪➨ 40 ᅇ ᪥ᮏẘᛶᏛ఍Ꮫ⾡ᖺ఍㸦༓ⴥ㸧㸪(2013) 17)బ⸨ᓫᘯ㸪㟷ᓥᆒ㸪ᒣ⏣ᗣᯞ͆࢝ࣉࢧ࢖ࢩࣥཷᐜయ(TRPV1)άᛶ࡟స⏝ࡍࡿ≀㉁ࡢ
᳨ウ͇㸪᪥ᮏ㎰ⱁ໬Ꮫ఍୰ᅄᅜᨭ㒊➨ 36 ᅇㅮ₇఍㸦ᓥ᰿㸧㸪(2013) 18)୰㊰ᫀᚿ㸪ᑠᕝᬛᘯ㸪ᒣ⏣ᗣᯞ͆ࣄࢺ⚄⤒ⱆ⣽⬊⭘ SK-N-SH ࡟ᑐࡍࡿ㓟໬ࢫࢺࣞࢫಖㆤຠᯝ͇㸪᪥ᮏ㎰ⱁ໬Ꮫ఍୰ᅄᅜᨭ㒊➨ 36 ᅇㅮ₇఍㸦ᓥ᰿㸧㸪(2013) 19) Watanabe Y, Kono Y, Hinohara T, Adachi S, “Stability of O/W Emulsion withLimonene through Freezing and Thawing”, 2nd Finnish-Japanese BilateralSymposium, “Nano-emulsions and encapsulation for delivering functionality infoods” (Takamatsu), (2013-9)－ 32 －  ㅮ₇  ௳ 1) ⓑ▼ᾈᖹ㸪͆ᮾࢯ࣮ᰴᘧ఍♫ᅄ᪥ᕷ◊✲ᡤᣍᚅㅮ₇ࠕ⣽⬊࣐࢖ࢡࣟ࢔ࣞ࢖ࢆ⏝࠸ࡓ⣽⬊⼥ྜ࣭⣽⬊ᅇ཰⿦⨨ࡢ᪂つ㛤Ⓨ͇ࠖ㸪2013.5.14㸦୕㔜┴㸸ᮾࢯ࣮ओᅄ᪥ᕷ◊✲ᡤ㸧2) ⓑ▼ ᾈᖹ㸪͆㏆␥኱ᏛᕤᏛ㒊බ㛤ㅮᗙࠕ⣽⬊࡟␒ྕࢆ௜ࡅࡿ"᪂ࡋ࠸⣽⬊᧯సࡢࣉࣛࢵࢺ
ࣇ࢛࣮࣒๰〇ࢆ┠ᣦࡋ࡚͇ࠖ㸪2013.7.6㸦ᮾᗈᓥ㸸㏆␥኱ᏛᕤᏛ㒊㸧3) ⓑ▼ᾈᖹ㸪͆᪥ᮏࢦ࣒༠఍㛵すᨭ㒊ㅮ₇఍ࠕ࣓࢝ࢽ࢝ࣝゎ⧄ࢭ࣮ࣝࣟࢫࢼࣀࣇ࢓࢖ࣂ࣮㓄ྜ࡟ࡼࡿኳ↛ࢦ࣒ࡢ≀ᛶᨵၿ͇ࠖ
㸪2013.8.23㸦ᗈᓥ㸸ᗈᓥᕷᕤᴗᢏ⾡ࢭࣥࢱ࣮㸧4) ⓑ▼ᾈᖹ㸪ᒣ⏣ᗣᯞ㸪͆⏘⥲◊◊✲ᡂᯝሗ࿌఍ࠕࣂ࢖࣐ࢫ⣔ཎᩱࡢᶞ⬡ཬࡧࢦ࣒࡬ࡢࢭ࣮ࣝࣟࢫ」ྜᮦᩱ໬ᢏ⾡࡟㛵ࡍࡿ◊✲͇㸪2013.11.13㸦ᮾᗈᓥ㸸 ⊂ ⏘⥲◊୰ᅜࢭࣥࢱ࣮㸧5)

Yasue Yamada,“The biological activity of various compounds in sake (Japanesetraditionalliqur from rice)” ,2013.10.30 (Palacky University, Centre of the Region
Haná for Biotechnical and Agricultural Research)6)Ώ㑓⩏அ㸪͆◊✲බ㛤ࣇ࢛࣮࣒ࣛ 2013ࠕRAMOS ࡟ࡼࡿ኱⭠⳦ࡢᅇศᇵ㣴࡟࠾ࡅࡿ௦ㅰάᛶࡢ

ᐃ࡜࣮࢜ࣂ࣮ࣇ࣮ࣟ௦ㅰࡢࣔࢹࣜࣥࢢ͇ࠖ㸪2013.10.28㸦ᗈᓥ㸸࣓ࣝࣃࣝࢡᗈᓥ㸧  ≉チฟ㢪  ௳ 1) ⓑ▼ᾈᖹ㸸2 ௳  ࡑࡢ௚  ௳ 1) ⓑ▼ᾈᖹ㸸௻ᴗ➼ᢏ⾡ᣦᑟ㸦24 ௳㸧2) ⓑ▼ᾈᖹ㸸ᖹᡂ 25 ᖺᗘ⤒῭⏘ᴗ┬ᡓ␎ⓗᇶ┙ᢏ⾡㧗ᗘ໬᥎㐍஦ᴗሗ࿌᭩
3-4) ⓑ▼ᾈᖹ㸸ጤク◊✲ሗ࿌᭩㸦2 ௳㸧5) ᑠᕝᬛᘯ㸸ᖹᡂ 24㹼25 ᖺᗘᒣ⏣㣴⻏ሙࡳࡘࡤࡕ◊✲ຓᡂᇶ㔠ሗ࿌᭩㸬እ㒊㈨㔠⋓ᚓ  ௳ ࠙➇தⓗ㈨㔠ࠚ1) ⓑ▼ᾈᖹ㸪ᒣ⏣ᗣᯞ㸸⤒῭⏘ᴗ┬ ᡓ␎ⓗᇶ┙ᢏ⾡㧗ᗘ໬ᨭ᥼᥎㐍஦ᴗᖹᡂ 24㹼26 ᖺᗘࠕ࣮ࣞࢨ࣮ග࡜㧗㏿ྍືࢫࢸ࣮ࢪࡢ⢭ᐦไᚚ࡟ࡼࡿ㧗ຠ⋡⣽⬊⼥ྜ࣭ᅇ཰⮬ື໬⿦⨨ࡢ㛤Ⓨࠖ㸦◊✲๪௦⾲⪅㸸ⓑ▼ᾈᖹ㸧࠙ጤク◊✲㈝ࠚ
1) ⓑ▼ᾈᖹ㸸௦⾲⪅㸦2 ௳㸧2) ᒣ⏣ᗣᯞ㸸௦⾲⪅㸦2௳㸧㸪ศᢸ⪅㸦1௳㸧3) Ώ㑓⩏அ㸸௦⾲⪅㸦1 ௳㸧4) ᑠᕝᬛᘯ㸸◊✲ຓᡂ㔠 ࠕ㠀࢔ࣝࢥ࣮ࣝᛶ⬡⫫ᛶ⫢⅖(NASH)࡞࡝ࡢ⫢㞀ᐖ࡟ᑐࡍࡿࣉ࣏ࣟࣜࢫᡂศࡢຠᯝࠖᒣ⏣㣴⻏ሙࡳࡘࡤࡕ◊✲ຓᡂᇶ㔠㸦௦⾲⪅㸧㸬Ꮫእවົᴗົ1) ⓑ▼ᾈᖹ㸸♫ 㧗ศᏊᏛ఍୰ᅜᅄᅜᨭ㒊ᖿ஦୍♫ ᪥ᮏࢦ࣒༠఍➨ 50 ᅇኟᮇㅮᗙ㐠Ⴀጤဨ － 33 －2)ᒣ⏣ᗣᯞ㸸᪥ᮏ㣗ရ࣭ᶵᲔ◊✲఍ ⌮஦ ᪥ᮏ⸆⌮Ꮫ఍ ホ㆟ဨ3)Ώ㑓⩏அ㸸♫ ᪥ᮏ㣗ရᕤᏛ఍ホ㆟ဨ4)ᑠᕝᬛᘯ㸸බ❧኱Ꮫἲே኱㜰ᕷ❧኱Ꮫ ᐈဨ◊✲ဨ㸬ࡑࡢ௚
ͤ%LRWHFK㸫➨  ᅇᅜ㝿ࣂ࢖࢜ࢸࢡࣀࣟࢪ࣮ᒎ㸭ᢏ⾡఍㆟㸫ฟᒎ㸦࣮ࣜࢻ࢚ࢢࢪࣅࢪࣙࣥࢪࣕࣃࣥओ㸧1) ⓑ▼ᾈᖹᒣ⏣ᗣᯞ㸸ᖹᡂ 25 ᖺ 5 ᭶ 8 ᪥㸦Ỉ㸧㹼5 ᭶ 10 ᪥㸦㔠㸧㸪ᮾிࣅࢵࢡࢧ࢖ࢺすᒎ♧ሙ㸪఍㆟Ჷ 1F ࣞࢭࣉࢩ࣮ࣙࣥ࣍ࣝͤࣉࣞࢫⓎ⾲ ⓑ▼㸪ᑠᕝ 1) ⓑ▼ᾈᖹ㸸ࢦ࣒⏘ᴗࢽ࣮ࣗࢫࠕ᪥ᮏࢦ࣒༠఍㛵すᨭ㒊ᗈᓥ࡛ྜྠᙺဨ఍ ㏆኱ᕤᏛ㒊ⓑ▼ᩍᤵࡀᇶㄪ
ㅮ₇ࠖᖹᡂ 25 ᖺ 9 ᭶ 5 ᪥㸦ᮌ㸧➨ 126 ྕ2) ⓑ▼ᾈᖹ㸪ᑠᕝᬛᘯ㸸㉥✑Ẹሗࠕ͆ᩍᖌࡢ༸͇ࡀฟ๓ᤵᴗࠖᖹᡂ 25 ᖺ 9 ᭶ 14 ᪥➨ 2053 ྕͤ◊✲ᡂᯝά⏝ᩍ⫱◊✲㐃ᦠ3) ⓑ▼ᾈᖹ㸸ᗈᓥ኱Ꮫ኱Ꮫ㝔≉ู◊✲Ꮫ⏕ไᗘ㸦ᗈᓥ኱ᏛᕤᏛ◊✲㝔኱ୗί἞ᩍᤵඹྠ㸧㸦ᅛయ㧗ศゎ⬟᰾☢Ẽඹ㬆྾཰⿦⨨ࡢᐃἲ࡜ᛂ⏝࡟ࡘ࠸࡚㸧4) ⓑ▼ᾈᖹ㸪ᑠᕝᬛᘯ㸸රᗜ┴❧㉥✑ᕷ❧᭷ᖺ୰Ꮫᰯ ᩍ⫱㐃ᦠᤵᴗࠕ㔝⳯ࡸ㨶࠿ࡽ DNA
ࢆྲྀࡾฟࡍ㸬࣑ࣝࣀ࣮ࣝ཯ᛂࡢⓎගほᐹࠖᖹᡂ 25 ᖺ 8 ᭶ 8 ᪥ ௨ୖ

－ 34 －