GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITYINDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

8

Features of Education ………………………………………………………………… 10

Description of Lectures held in English ………………………………… 11
Outline and Composition of Departments …………………………… 17
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 19
Department of Gene Mechanisms ………………………………………………… 20
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Department of Cell and Developmental Biology ……………………………… 21
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 22
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 23
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 25
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 26
Laboratory of Genome MaintenanceLaboratory of Nanobiology
Laboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 27
Laboratory of Molecular and Cellular Immunology
Laboratory of Developmental Dynamics

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 29
Department of Molecular and System Biology…………………………………… 30
Laboratory of Single-Molecule Cell Biology
Laboratory of Bioimaging and Cell Signaling

INDEX

Department of Animal Development and Physiology ………………………… 31
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology and Development
Department of Signal Transductions ……………………………………………… 34
Laboratory of Molecular Neurobiology
Laboratory of Genetics
Department of Functional Biology ………………………………………………… 35
Laboratory of Functional Biology
Department of Biostudies and Society …………………………………………… 35
Laboratory of Science Communication and Bioethics
Laboratory of Science Communication
Laboratory of Bioeducation
Department of Mammalian Regulatory Network ……………………………… 37
Laboratory of Cell Regulation and Molecular Network
Laboratory of Viral Oncology
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information
Laboratory of Bio-functions Biomaterials
Laboratory of Cellular and Molecular Biomechanics

Organization ………………………………………………………………………… 41
Map & Access ……………………………………………………………………… 42
Contact ………………………………………………………………………………… 44

Greeting fromthe Dean of
the Graduate School
Dean: ISHIKAWAISHIKAWA, Fuyuki,
Fuyuki MD,
MD PhDESTABLISHMENT AND HISTORY
OF THE GRADUATE SCHOOL OF
BIOSTUDIESThis experience lead us to be selected as one of theschools of the 21ST Century COE Program（21 世 紀 COE
プログラム）in 2002. Furthermore, we were selected as aschool of the “Initiative Project for Attractive Education

Life Science is the study of life in all of its forms andin Graduate School（ 魅 力 あ る 大 学 院 教 育

イニシア

complexity. It encompasses the totality of life forms” and the “Support Program for Education
テ ィ ブ 事 業）

from viruses and bacteria to human beings, and its

Reformation of Graduate School（大学院教育改革支援プ

analyses involve molecules, genes, cells, tissues, living” in 2006 and in 2008, respectively.
ログラム）

organisms, and eco-systems in diverse phases. Life is

We are proud of our educational program. With

not a “molecular machine”. Therefore, it is necessary

support from a variety of projects, we have been diligent

to bring the context of life into the research effort. It

to provide bold and efficient curriculums that reflect therequires using various approaches, various disciplines,

students’ feedback and discussions with teaching staff

and various fields of study. In addition, those who wish

and administrators, who are passionate to improve theto excel in the life sciences must bring to their studies a

graduate education system. We attach particular weightstrong sense of ethics. Biostudies researchers must be

to nurturing students’ autonomous attitudes, allowing

more than manipulators of molecules.

students to develop their own thoughts and originality,

Those trained in specialized disciplines within

to have their own voice and points of view presenting

agriculture, medicine, and pharmacology, where

their own ideas, and to solve problems with innovative

studies in the life sciences were traditionally pursued inapproaches. New discoveries arising from their daily

the past, have independently contributed greatly to

training should be shared at the global level. With thisthe current knowledge base. These accomplishments

goal in mind, a foreign professor, who is a native English

notwithstanding, it is manifestly essential for researchers

speaker and experienced in Life Science research,

to place their work within the whole framework of “Life”

instructs students to improve their discussion, writing, andand to encourage each other as people who love

presentation skills. Students are encouraged to present

life. With such needs and expectations both internally

their research at international meetings, and dissertations

and externally, the Graduate School of Biostudies was

are now accepted in either Japanese or English.

established in 1999, to engage in 21st Century Life
Science as a comprehensive science.

Our research has been frequently cited andis ranked at the forefront of the global scene. Our

It has been 17 years since the school was established.

faculty, who have diverse backgrounds, explore new

In that time, we have accepted numerous students anddirections of research, sharing their own knowledge,

have sent into society graduates who were raised toskills, and ideas with frank discussion in the appropriate

be outstanding researchers through the leadership offorums of the public and research environment. We are

our former deans, Kanji Ohyama, Mitsuhiro Yanagida,

actively collaborating with private/public sectors andKayo Inaba, Eisuke Nishida, and Shin Yonehara.

are attracting competitive external public funding for

Simultaneously, we have published many cutting-edge

research. At the same time, we strongly hope that the

research findings.

fruits of our research will contribute to social happiness.

In 2001, we were selected as an educational base of

Most of our laboratories are located at the Souththe MEXT Center of Excellence Formation Project（COE）.

Campus and the North Campus, improving their research

4

GRADUATE SCHOOL OF BIOSTUDIES

and education in the respective research complexes.

School of Biostudies.

Despite the physical distance between the campuses,(1) The Division of Integrated Life Sciences: cell devel-

the graduate students and teaching/administrative

opment, cell growth, genetic information and cell

staff communicate closely, while upholding the tradition

cycle regarded as a multicellular system, and thethat respects diversity and free-ranging inquiry. This has

totipotency, the mechanism of signal transduction

also engendered a friendly and lively atmosphere toand the responses among the cell, living being andencourage each other.

environment.

All in all, we are pioneering a new Life Science withhope and responsibility. We recognize our responsibility(2) The Division of Systemic Life Sciences: neuroscience,

and are full of hope and confidence that we can reachanimal development and physiology, immunobiol-

our goals. Although we are still a young organization, or

ogy and others.

perhaps because we are a young organization, we will
do our best to bring our school mission and the research

AIMS OF THE GRADUATE SCHOOL OF BIOSTUDIES

fields listed below to fruition. We sincerely appreciate(1) Training of individuals with the most advanced

your further support.

knowledge of the life sciences for the next generation

The three goals of the graduate school(1) Provide education for pursuing the new biostudies at
the world's top level

The graduate student studies a higher level of life
sciences beyond the structures of past life sciencerelated fields at each undergraduate level to un-

To meet the demands of the industry, college,

derstand the integrated life sciences. The goal is toresearch institutes and administrative organizations,nurture a new type of individual with creative andindividuals are educated in the life sciences andinnovative abilities to cope with the various unknown

master the techniques for the society needs.

themes to be confronted by human beings in thenext generation.

(2) Train individuals to apply the new life sciences forthe protection of the global environment and for human welfare(2) Training to establish self for society
In the Graduate School of Biostudies, individuals

Integrate the knowledge and technology inare trained to make a healthy and fair judgment

the old fields of science, agriculture, medicine andbased on the academic background of the staff

pharmacology, and nurture individuals who canand their prospects for the future; and, establish acontribute to the human society in the 21st century.

new system to evaluate the effects of educationfrom multiple aspects from the past.

(3) Nurture individuals who can understand the various
vital phenomena of the living organisms as a systemic function, and pursue these systemic functions(3) Activation and flexibility of staff in the human relations

Nurture individuals who will be leaders in the human

Research is pursued by each staff member inde-society to pursue their activities for the welfare and hap-pendently to develop a new life science based onpiness of humans in the 21st century, where humans will

active exchange among the various laboratories in

be living in harmony with other living beings.

the graduate school.

In order to meet the demands of the changing
society in the 21st century, which will be impossible(4) Use of current post-doctoral system and evaluationof academic activities

to cope with in the current research academic

Full use should be made of the current system, tosystem for the life sciences, a new research andprovide the increasing necessary number of instruc-education system is installed to breakdown the walls

tors per student, for the intensive training to becomethat have hindered the research in the life sciences

life scientists at an international level, for true devel-in the past. There are two courses in the Graduate

opment of a new research field.

GRADUATE SCHOOL OF BIOSTUDIES

5

Policy
Admissions Policy

possess the pioneering spirit to help propel the

Mission and Desired Student Profile

comprehensive and advanced branches of the

As an advanced discipline that holds the key
to the future of humankind, the life sciences arelife sciences into new territory, while appreciating
the dignity of life.

currently undergoing a major evolutionary change.
The Graduate School of Biostudies was inaugu-

Curriculum Policies

rated in 1999 as the first independent school of its

1. The master's program provides a broad educa-kind in Japan with the mission of accelerating thistion spanning all domains of the life sciences,global trend, building a world-class center for re-and cultivates a foundation of competence forsearch, and training the human resources to leadoccupations that demand research abilities andthe life sciences field into the next generation. Ouradvanced expertise in specialized fields.

school has engineered a fusion of cutting-edge

2. The doctoral program endeavors to impartareas in several existing fields and harnessed thecutting-edge specialist knowledge backed bycommon languages of cellular and molecular biol-

diversified academic research, and to cultivate

ogy and genetics that together articulate the prin-independent researchers who can perform wellciples of life. Furthermore, it has developed an inte-

in an international setting. Additionally, it equips

grated understanding of diverse life forms and theadvanced professionals with the knowledge andenvironments they help shape, and has launchedskills required for occupations in specialized fields

innovative efforts in research and education that

as well as the ability to integrate those strengths

will define a new set of values for the future andand assume leading roles.

dignity of life.

3. Students develop the ability to accurately place

To meet the diverse expectations of society

their own research into perspective with theirfor advances in life science, which is becoming in-

specialization, discuss and debate the findings

creasingly sophisticated and complex, the Gradu-

and their significance in an international setting,ate School of Biostudies endeavors to cultivate hu-

and build frameworks for collaboration, as nec-

man resources with the following attributes.

essary.

1. Researchers ready to shed fresh light on, and

4. The curriculum is organized and implemented so

discover, the fundamental principles of life andthat students can apply broad visions to put theirpursue world-class research in new areas of theown research into perspective, build systems oflife sciences

knowledge, and pursue cross-disciplinary study

2. Researchers and advanced engineers commit-

unencumbered by existing fields of specializa-

ted to global environmental conservation andtion. This approach lays the groundwork for thegains in human health, welfare, and well-being,creation of new knowledge with which students

and ready to make social contributions throughwill be ready to tackle unknown fields with a tire-

roles in public and private research institutions

less spirit of innovation.

3. Educators and working professionals with a

5. As they pursue their research at deeper levels,

broad-based understanding of the varied phe-students develop the power to reflect on theirnomena of life in general and ready to makeown research with firm ethical integrity and asocial contributions through roles in education,strong sense of responsibility, and continually in-industry, the news media, and government

quire whether it is consistent with the harmonious

We seek students from a broad spectrum of

coexistence of humanity and nature.

backgrounds who share our values and desire to

6

continue their education through our programs.

Diploma Conferral Policies

We especially welcome students who are both

1. To be eligible for a degree, candidates in theknowledgeable and free of preconceptions, andmaster's program must be: enrolled for a mini-

GRADUATE SCHOOL OF BIOSTUDIES

mum of two years; complete courses offered bytence of humanity and nature.

the School, lab experiments, and practical train-

Doctoral candidates that excel in their re-ing; and attend seminars offered by the labora-

search performance may be deemed eligible for a

tory to which they belong. Candidates need

one-year minimum enrollment requirement insteadto acquire at least one credit hour in requiredof the three-year minimum mandated in item 3

subjects, nine credit hours in elective subjects,

above.

and 20 credit hours in lab experiments, practical training, and seminars. Candidates also must
pass a thesis review and examination administered by the School. To pass the review, the thesis must be logically and consistently written, andmust detail new discoveries or initiatives that willcontribute to insights and advances in the life
sciences.
2. As tangible benchmarks for successful completion of the master's program, candidates will
be expected to demonstrate that they haveacquired a wealth of scholarly knowledge andinsight, research ability in their field of specialization, and the foundation of competence for occupations that demand advanced expertise.
3. Doctoral degree candidates must be enrolled
for a minimum of three years as well as complete
courses offered by the School and seminars offered by the laboratory to which they belong.
Candidates need to acquire at least one credit
hour each in required and elective subjects andeight credit hours in seminars. Candidates also
must be granted research guidance approvaland pass a dissertation review and examination
administered by the School. The doctoral dissertation must be logically and consistently presented, and must detail new discoveries or concepts
that contribute to understandings and advancesin the life sciences.
4. As tangible benchmarks for successful completion of the doctoral program, candidates will be
expected to show that they have acquired theskills and expertise to engage as independent
researchers or lead careers in advanced professional occupations.
5. As another important criterion for consideration
upon completion of their program of study,
doctoral candidates will be evaluated to determine whether they have pursued their researchwith firm ethical integrity and a strong sense of
responsibility, and have confirmed that theirresearch contributes to the harmonious coexis-

GRADUATE SCHOOL OF BIOSTUDIES

7

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained to discuss anddebate scientific matters and research outcomes.
Students are also trained to have a broad outlook and flexible thinking in life sciences, and areencouraged to travel to international scientificmeetings.

by the end of September. Thus, applicants can select the starting date of either October 1st or April
1st in the next year. At the time of application, prospective students must identify which laboratory
head will direct their doctoral research. Applicants
can apply for only one lab. Thus, applicants must
contact the lab head and fully discuss potential
research activities and availability before filingthe application.
Admission examinations for the Doctoral program consist of a documentation screening and anoral examination (interview) to evaluate applicants’knowledge of their field, research competency,
logical thinking skills, and the ability to discuss science in English. Please note that applicants are NOT
required to be physically present in Japan for the“Global Frontier in Life Science”
The Graduate Schools of Biostudies and Medi-

examination.
2) Master’s Program in "Global Frontier in Life Science"cine offer "Global Frontier in Life Science", a joint

Our entrance examination for the Master’s

educational program for Doctoral and Master’s

program is held in July. The guidelines for admission

students as part of K.U. PROFILE (Kyoto University

are posted in April on our web site (http://www.

Programs for Future International Leaders: http://

lif.kyoto-u.ac.jp/e/). The academic year starts on

www.opir.kyoto-u.ac.jp/kuprofile/). This program,

October 1st or April 1st for those who cannot obtain"Global Frontier in Life Science", is held entirely ina "college student visa" by the end of September.

English, including the entrance examinations, lec-Thus, applicants can select the starting date oftures, experiments, and discussions.

either October 1st or April 1st in the next year. Appli-

International as well as domestic students arecants to the Master’s program can apply for up to

welcome. In particular, the program welcomes

two labs in which they wish to conduct research.

those who show a respect for life and a desire toThus, applicants should familiarize themselves

create a comprehensive and cutting-edge fieldwith faculty members’ research interests and mustbeyond existing disciplinary boundaries in life sci-contact lab head(s) to fully discuss prospective re-ences.

search activities and availability before filing theapplication.

1) Doctoral Program in "Global Frontier in Life Science"

Admission examinations for the Master’s pro-

The two graduate schools hold independent

gram consist of: 1) a documentation screening

entrance examinations for this program, and ac-and 2) an oral examination (interview). Please note

cept up to ten applicants. Our entrance examina-that applicants are NOT required to be physicallytion for the Doctoral program is held in July. The

present in Japan for the examination.

guidelines for admission are posted in April on
our web site (http://www.lif.kyoto-u.ac.jp/e/). The
academic year starts on October 1st or April 1st for
those who cannot obtain a "college student visa"

8

GRADUATE SCHOOL OF BIOSTUDIESLectures held in English for “Global Frontier inLife Science”

and an examination upon completion of the Master’s thesis written under the supervision of faculty.

1) Doctoral program
Offered by the Graduate School of Biostudies
・Frontier in Life Science (1 credit : compulsory)
・Advanced English Discussion and Writing in Life
Science I (1 credit)
・Advanced English Discussion and Writing in Life
Science II (1 credit)
2) Master’s program
Offered by the Graduate School of Biostudies
・Life Science : From Basics to Applications, from
Molecular Biology to Systems Biology (1 credit :compulsory)
・Beginning Science (1 credit)
・Global Frontier in Life Science A (2 credits)
・Global Frontier in Life Science B (1 credit)
・Advanced Molecular and Cell Biology I (2 credits)
・Advanced Molecular and Cell Biology II (2 credits)
・Cancer Biology (2 credits)・Basic English Discussion in Life Science I (1 credit)・Basic English Discussion in Life Science II (1 credit)
・Cellular & Molecular Neuroscience (1 credit)

Requirements for completing programs
1) Requirements for completing the Doctoral program・" The Life-Science Special Exercises" (8 credits :compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 1 credit)
For graduation, the student must have enrolled
for at least three years and have completed
at least 10 credits. It is also required to pass theprobation and the examination (thesis defense)
upon completion of a Doctoral thesis written under the supervision of faculty.
2) Requirement for completing the Master’s program
・"The Life-Science Experiments and Exercises 1" (10credits : compulsory)
・"The Life-Science Experiments and Exercises 2" (10credits : compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 9 credits)
For graduation, the student must have enrolled
for at least two years and have completed at least
30 credits. It is also required to pass the probation

GRADUATE SCHOOL OF BIOSTUDIES

9

Features of Education
Features of Education
From 2006 to 2007, we conducted the "Biostudies Career-Development Program" supported by
the Ministry of Education, Culture, Sports, Scienceand Technology. From 2008, we have launched
the "Program for Developing Pharmaceuticalthe development of English communication skills
for students. Our school has been emphasizing thedevelopment of communication skills in English. We
encourage and financially support our students togive talks at international conferences abroad. We
also give them advice for their presentation skills.

Strategists" as one of the projects of "Reforming
Programs in Education" at Kyoto University. This

3) Workshops organized by students

program, in cooperation with the Graduate SchoolStudents in life science fields tend to stay inof Pharmaceutical Sciences, is aimed to reformtheir labs because they are busy working at thethe educational system of graduate schools inbench. However, it is highly important to commu-

our university. Launched in 2011, we are conduct-

nicate with other students studying life science in-ing a new program named "Global Frontier in Life

side and outside of our school during the course of

Science". In 2012-2013, we were selected as one

education. We encourage and financially supportof the schools of the “MEXT Excellent Graduate

the students to organize and conduct workshops

School Hub Formation Project ” and supported ourby themselves.

Doctoral students with the subsidy. We are hoping that our students will understand the essential
aspects of the programs and cooperate with us inachieving their goals.

4) Guidance by multiple supervisors
Heretofore, students who were assigned totheir laboratories studied under the supervision of
one faculty member. However, it would be highly

Outline of Reforming Programs in Education
1) Lectures
In our Master’s program, the curriculum is designed to make the students systematically understand life science and its related fields. We offer aninherent lecture for understanding, revealing, andcultivating the relationship between life science andour society. In our Doctoral program, advanced
courses in life science are offered in addition to theseminars at the lab where each student belongs.
This program has been ongoing since 2006. We gear
the program to provide the requisite knowledge
and experience for the students' future careers invarious fields of Industry, Government, and Academia, at home and internationally.
2) Emphasis on English communication for life science, with support for attendance at international scientific meetings
It is now very important to give seminars in
English, especially scientific presentations at international meetings. Historically, however, the graduate schools in our country scarcely cared about

10

GRADUATE SCHOOL OF BIOSTUDIES

stimulating for the students if they could haveopportunities to discuss their research and othermatters with other faculty members. In our school,
each student is strongly encouraged to consult
with two additional supervisors for his/her current
research and also career objectives. We hope thatthe practice widens their vision on life science andon their future plans.
5) Global Frontier in Life Science (Program conducted in English)
The Ministry of Education, Culture, Sports, Science and Technology launched the "Global 30"
Project for Establishing Core Universities for Internationalization, for the purpose of selecting universities that will function as core schools for receiving
and educating international students. In 2009,
thirteen universities including Kyoto University wereselected. These core universities are playing a major role in dramatically boosting the number of international students educated in Japan as well asJapanese students studying abroad.

Description of Lectures held in
EnglishMaster’s Program

fundamental concepts, and knowledge in several
different research fields in life sciences. Lecturers

Beginning Science ...........................................................................................................................................
Lecturers: Uemura, Hejna
Hejna）（Lecturers:

are mostly young scientists, who have recently
started his or her own researches as lab heads inThis class will cover the history of life science, theKyoto University. In addition, the lecturers will pro-basic phenomena in this field, research meth-vide their experience such as how they have foundodologies, papers that impressed the lecturers

enthusiasm in life science research.

themselves, seminars, and meeting other scientists,
as the beginning of research. Moreover, rules of

Global Frontier in Life Science B .........................................................................

research and proper analysis of data will be dis-

Lecturers: Hejna, Chisaka, Nishihama
Nishihama）（Lecturers:

cussed. Furthermore, to broaden students’ views of
their career path, and their future roles as scientists
in the greater context of our society, we would liketo discuss what Professionalism means, in terms ofcommon sense, regardless of particular career objectives, and how to develop systematic and critical thinking skills.

International scientific communication is conducted virtually exclusively in English. Students inthis class will be provided opportunities--and will
be expected--to actively practice and refine theiroral presentation skills in English. The class format
will consist of medium-length (about 30 min.) student presentations (depending on enrollment andgroup discussions, in addition to impromptu exer-

Life Science:
From Basics to Applications, from Molecular
Biology to Systems Biology...................................................................................................
Lecturers: Hejna, Nagao, Kambe, Kumeta, Ha（Lecturers:
rada, Masuda）
MasudaThis class will be conducted entirely in English, andcises to further develop reading and listening comprehension. Each class will be a standard 90 min.
class, scheduled from 10:30 am-12 noon. The classis meant to be a forum in which to improve English
language fluency and presentation skills, and thecontent will cover current topics in bioscience.

is designed to acquaint students with a broad
range of research areas and methodologies, while

Advanced Molecular and Cell BiologyⅠ ..........................

encouraging students to consider the adaptability

Lecturers: Chisaka, Kumeta, Kengaku, Yonehara,（Lecturers:

or combination of methods in other systems. Topics

Kakizuka, Hejna）
Hejna

will range from a quick review of basic molecular biology techniques, to presentations on signaltransduction, transport proteins, applications offluorescence technology, genomewide screening,
single-molecule imaging, systems biology, regenerative medicine, tissue growth and regulation,and the hot topic of RNA research. Discussion is
also encouraged. The class is primarily for first-year
Master's students. Other students, especially G30
students, are equally welcome.

This will be a lecture course with a limited numberof students (up to 30). The students will be given
5-8 scientific papers to read. Special emphases will
be on the biologists’ way of thinking as well as thebasic concepts on the gene/protein structure andfunction.
1. Logic and basic concepts in biology : How doesa biologist work and what does a biologist know?
2. Methods in biology : What kinds of techniquedoes a biologist employ?
3. Specific topics deal with the cell structure andGlobal Frontier in Life Science A........................................................................

function, the nucleus and central dogma

Lecturers: Kakizuka and Others
Others）（Lecturers:
Lectures in “Global Frontiers in Life Science A” will
be held in English, and aim to provide basic and

GRADUATE SCHOOL OF BIOSTUDIES

11

Advanced Molecular and Cell BiologyⅡ ..........................

not yet have extensive research results to present,

Lecturers: Chisaka, Fukuzawa, Endo, Kumeta, Fu（Lecturers:

the class will consist of shorter (~30 min) student

jita, Kitajima, Hejna）
Hejna

presentations, covering recent science news,

This course is an intensive course to introduce themethods, and technology. Students are expectedunderlying cell signaling pathways and their me-

to contribute to the class by commenting and rais-

diators covering mammalian cells, plants and mi-

ing questions, at the same time strengthening theircrobes. The final goal of this course aims to provide

ability to look critically at the way science is pre-an overall knowledge regarding the diversity andsented.

significance of cell signaling events in response tovarious stimuli and physiological conditions, andCellular & Molecular Neuroscience.......................................................

the generality among species. The course will be

Lecturers: Hejna, Uemura, Kengaku, Matsuzaki,（Lecturers:

held in combination with related paper discussion.

Kakizuka, Oimuma）
OimumaStudents interested in cell and molecular biology

This course will be a joint course offered by theand cell signal transduction are encouraged to

Graduate School of Biostudies and the University

participate.

of California, San Diego, to provide cutting-edge
lectures by world-class neuroscientists and journal

Cancer Biology ...........................................................................................................................................................

presentations by students, to expand learning op-

Lecturers: Yoshimura, Ishikawa, Kakizuka, Kumeta
Kumeta）（Lecturers:

portunities beyond the confines of a single cam-In this course, a wide variety of recent topics onpus. Lectures will be broadcast by live satellite

cancer biology will be lectured by researchers

links between classrooms in San Diego and Kyoto.

working in different research fields and different

The course is intended for advanced students. It iscountries. A Long-distance learning system com-imperative that students should have a very solidbines Kyoto, Tsukuba and National Taiwan Universi-

background in neurobiology.Highly motivatedties to promote active interaction and discussion

Masters students will be admitted at the discretion

between lectures and students, as well as amongof the course organizers.

students in different universities.

Doctoral Program
Basic English Discussion in Life ScienceⅠ..........................
Lecturer: Hejna
Hejna）（Lecturer:
Despite having excellent English reading andwriting skills, most students, even native-English
speakers, need to improve their oral English communication skills in order to thrive in the new international scientific community. This class is designed
to provide students with ample opportunities topractice scientific discussions in English, while reviewing elements of English grammar and style as
they arise. An added benefit will be coverage ofa diverse range of current scientific topics; students
will begin to look critically at scientific data, and its
presentation.

Frontier in Life Sicence.........................................................................................................................
Lecturers: Kageyama and others
others）（Lecturers:
Prominent leading scientists from several research
fields of life science, especially those progressing
astonishingly, will provide their research histories
from their backgrounds to future prospects, to encourage young scientists to perform good science.

Advanced English Discussion andWriting in Life ScienceⅠ .................................................................................................................
Lecturer: Hejna
Hejna）（Lecturer:
Like it or not, career advancement depends upon
the ability of a researcher not only to read andwrite English, but to converse fluently in English.

Basic English Discussion in Life ScienceⅡ..........................
Lecturer: Hejna
Hejna）（Lecturer:This class is designed to build upon existing reading and writing skills by developing strengths in oralpresentation and discussion of science in English.
Aimed at Master's students in particular, who may

12

GRADUATE SCHOOL OF BIOSTUDIES

These skills are crucial for presentations at international meetings, international collaborations, peer
review of manuscripts, and professional networking.

This course will allow you to further develop

your English language skills by giving oral presentations. In addition, a homework writing exercise

will give you practice in writing a short document,■ Division of Integrated Life Sciencesuch as an abstract, a cover letter, or peer review.

Seminars on Gene Mechanism.............................................................................

Enrollment will be limited to just 3 students, to allow

This seminar outlines the principle concepts andeach student two 75-minute oral presentations,related research methods and discusses current

and ample opportunity for informal discussion in a

topics in Gene Biodynamics research. In addition,

low-stress environment.

students report and discuss their own researchdata to improve their research work and presenta-

Advanced English Discussion andWriting in Life ScienceⅡ .................................................................................................................

tion skills.

Lecturer: Hejna
Hejna）（Lecturer:

Seminars on Cell and Developmental Biology .

This class continues the development of presenta-

This seminar discusses the themes of Cell and De-tion and discussion skills in English, as in Advanced

velopmental Biology, Cell Recognition and Pat-

English Discussion and Writing in Life Science I, withtern Formation, and Cell Signal Transduction, andthe longterm goal of preparing you for an interna-

deepens understanding of the related areas. In

tional scientific career. This course will allow you

addition, students report and discuss their own

to further develop your English language skills by

research data to improve their research work andgiving oral presentations. Group discussions will bepresentation skills.

friendly, but objective.

In addition, a homework

writing exercise will give you practice in writing a

Seminars on Plant Genes and Totipotency.....................

short document, such as an abstract, specific aims,

This seminar discusses the latest developments inor peer review.

Enrollment will be limited to just 3

Molecular Biology (especially Genome Biology),

students, to allow each student two 75-minute oral

Molecular and Cellular Biology, and introduces

presentations, and ample opportunity for informal

research on Cellular Totipotency at the Molecular,

discussion in a low-stress environment.

Cellular, and organismal level. In addition, students
have exercises in problem-solving and discussionsof new research.

Seminars on Applied Molecular Biology................................
This seminar explains and discusses the latest issues
regarding environmental response mechanisms in
mammals or microorganisms, and the future direction of research applications.

Seminars on Molecular Mechanisms of
Responses to Environmental Stimuli........................................................
This seminar covers the latest issues regarding various internal and external biological responses, andareas in related fields with different points of view.

Seminars on Molecular and Developmental
Biology .....................................................................................................................................................................................................
This seminar focuses on how to bridge the gap
between individual molecular activities and pathophysiological regulation of the dynamic life systems
by using advanced single-molecule imaging and
FRET technologies.

GRADUATE SCHOOL OF BIOSTUDIES

13

Seminars on Mammalian Molecular andCellular Biology ..........................................................................................................................................................

■ Division of Systemic Life Science

This seminar discusses the biological mechanisms

This seminar discusses the solved and unsolvedof regulation related to carcinogenesis at the mo-

problems about the dynamic behaviors of DNA,

lecular, cellular, and organismal levels.

proteins and cellular structures in live cells in order

Seminars on Molecular and Systems Biology ........

to deepen the students’ understanding. Students
report their research progress and adjust the direction through discussion.

Seminars on Animal Development andPhysiology ....................................................................................................................................................................................
This seminar discusses the latest information regarding genetic regulation, from a broad perspective.
In addition, we cover explains illnesses such as
cancer caused by abnormal cell differentiationand proliferation, immunological disorders, genetic
disorders, and lifestyle related diseases, outlining
the research methods used to investigate the molecular biology and pathogenesis of adult diseases.

Seminars on Molecular Mechanisms of Signal
Transductions......................................................................................................................................................................
Cancer, autoimmune diseases, and life-style related diseases can be caused by genetic abnormalities and aberrant response mechanisms. This seminar explains and discusses dysfunctional biologicalmechanisms of cell proliferation, self- / non selfimmunological identification mechanisms, cancer,
immunological disorders, genetic diseases, andbiological mechanisms of adult diseases.

Seminars on Functional Biology...........................................................................
This seminar explains and discusses the latest information about molecular mechanisms of thehomeostatic regulation in physiological and pathological conditions.

Seminars on Cultural and Social Aspects ofLife Sciences.........................................................................................................................................................................
This seminar covers the theoretical research, themethodology of life science, bioethics, and the history of modern science.

Seminars on Mammalian Regulatory Network ..
This seminar discusses the mechanisms of systemic
biological cellular control, genetic response, carcinogenesis caused by viruses, the principle of immunological response; the structure and regulation of

14

GRADUATE SCHOOL OF BIOSTUDIES

genetic information responsible for such systemic
functions are being analyzed using model animals.

GRADUATE SCHOOL OF BIOSTUDIES

15

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism❖ How the brain and the body work・Department of Gene Mechanisms❖ How the body is built

log・Department of Molecular and Cellular Biology❖ How the human diseases occur
・Department of Molecular and System Biologyo❖ How multicellular organisms work
olo・Department of Cell and Developmental Biologyy・Department of Plant Gene and Totipotency
enta・Department of Molecular and Developmental
Biologyth❖ How organisms interact withenvironments

・Department of Animal Development andPhysiology
・Department of Signal Transductions
・Department of Functional Biology
ory NetNetwork・Department of Mammalian Regulatory

ethics❖ Communications・Bioethics
・Department of Biostudies and Societyy・Department of Applied Molecular Biology
ironmenta
・Department of Responses to Environmental
Signals and Stresses

Living organisms
ms

Human bbeingsGenes and cells

Outline and Composition of Departments

17

DIVISION OF INTEGRATED LIFE SCIENCEThis division consists of 18 laboratories including six cooperativelaboratories one from Radiation Biology Center, three from Institute for Virus Research, and two from Institute of Integrated Cell-Material Sciences(iCeMS). Fourty graduate students are accepted in the Master's Program
annually, and 19 in the Doctoral Program. In this division, education andresearch are focused on the elucidation of basic mechanisms regulating
the chromosome transmission, chromosome replication, RNA architecture,cell cycle, cellular transport, cell polarity, signal transduction, growth anddevelopment, developmental plasticity, bioconversion, and environmental adaptation. Experimental approaches are taken with microorganisms,
plants, and animals. We pursue education and research to elucidate themolecular aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanisms
D

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Associate Professor

NAKASEKO, Yukinobu■ Main theme

SHIRAISHI, Hideaki■ Main theme

We are focusing on analyzing the genes involved

We are interested in the mechanism of growth,

in regulation of chromosome function. Especially,

development and evolution of photosynthetic

the genes essential for mitosis have been studied.

microorganisms and currently focusing on the study

Fission yeast Schizosaccharomyces pombe is usedof the edible cyanobacterium Arthrospira (Spirulina)

as a model system. This yeast has all basic featuresplatensis. A. platensis is a filamentous alkaliphilic

essential for eukaryotic cell division. Many genes havecyanobacterium that has been traditionally consumed

been identified which regulate the cell cycle of thisas food by people living along the shores of alkaline

yeast. Also, their functions as well as their primarylakes in several regions in the world. Because it can be

structure have been shown to be conserved amongcultured under alkaline conditions where growth of

all eukaryotic cells. We are trying to characterize theseother microalgae is suppressed, it can be produced

genes and their functions by genetical approach.

in mass cultures outdoors as an almost single algal

Elucidation of whole functional network of thesestrain. Because of its easiness of mass culture, it isgenes is one of a goal in our research.

commercially produced in many subtropical areasin the world and consumed worldwide as food, foodadditives, and feed for animals and fishes. Since it
exhibits many biologically interesting phenomena,
we are currently focusing on the study of thiscyanobacterium. Examples of our current research
projects include developing tools for molecular
genetic studies of Arthrospila, analyzing extracellularpolysaccharides produced by it, and investigating themechanism of its motility.

http://kuchem.kyoto-u.ac.jp/seika/

20

DIVISION OF INTEGRATED LIFE SCIENCEDepartment of Celland Developmental Biology

Laboratory of Cell Cycle Regulation

Laboratory of Cell Recognition and
Pattern Formation■ Professor■ Assistant Professor■ Professor■ Assistant Professor■ Assistant Professor

ISHIKAWA, Fuyuki
SADAIE, Mahito■ Main theme

UEMURA, Tadashi
USUI, Tadao
HATTORI, Yukako■ Main theme

Our research activity focuses on the molecular

We are interested in mechanisms that control

mechanism of the flow of genetic infor mation.

animal development and behaviors in response to

Chromosomes, the vehicle of genetic materials,

two categories of environmental inputs: nutrition andshow both faithful and flexible behaviors, in different

sensory stimuli. Diet is one of critical environmental

time scales, from a single round of the cell cycle todeterminants that affect developmental time andthe evolution of species, and in different conditions,fitness. We are studying genetic programs for dietarysuch as development, aging and cancer. These

responses of ecologically distinct Drosophila species

apparently opposite behaviors of chromosomes canthat have different dietary preferences. We are

be explained by the need of genetic materials to bealso focusing on how developing neurons copetransmitted robustly. We are particularly interested

with nutritional restriction by using one subclass ofin how functional domains of chromosome, such as

Drosophila somatosensory neurons. By using thetelomeres, are established and maintained, and how

same neuronal subclass, we are dissecting operating

chromosomes respond to external stimuli, as exemplified

principles of neuronal circuits that evoke selectiveby the genetic instability found in cancer cells. We are

behavioral outputs in response to sensory stimuli.

trying to understand these questions by experimental

To conduct these studies, we introduce a variety

approaches based on genetics, biochemistry, andof molecular, cellular, genomic, imaging, andmolecular and cellular biology in various model systems,

physiological approaches.

such as fission yeast, and mammalian cells.
1) Closed

2) Semi-open

TelomeraseP3) Open

DNA damage
response

Telomeres consist of DNA ends and the shelterin protein
complex.
1) Long telomeres form a closed state competent toprotect telomere ends. 2) Moderately short telomeres
recruit telomerase to elongate telomere DNA. 3) Very short
telomeres are deprotected, activating the DNA damage
response. Phosphorylation of the shelterin protein regulatethese processes. Yamazaki et al. Genes & Dev. 26:241 (2012)
http://www.fish.lif.kyoto-u.ac.jp/

http://www.cellpattern.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

21

Division of Integrated
Life Science
Department of Plant Gene and Totipotency

Laboratory of Signal Transduction

Laboratory of Plant Molecular Biology■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

NISHIDA, Eisuke
MIYATA, Yoshihiko
KUSAKABE, Morioh■ Main theme

KOHCHI, Takayuki
NISHIHAMA, Ryuichi
YAMAOKA, Shohei■ Main theme

We are interested in identifying and elucidating

Research in this laboratory focuses on the adaptive

molecular mechanisms that regulate cell

regulation of growth and development to environmental

proliferation, cell differentiation, cell cycle, aging

conditions using model photosynthetic organisms.

and developmental processes. The current topics

Topics include mechanism of photomorphogenesis

include 1) regulatory mechanisms and functions ofand meristem development. We study molecular

the MAP kinase cascade pathways, 2) identification

mechanisms of light sensing by photoreceptors andof novel signal transduction mechanisms, 3) molecular

downstream genetic network of signal transduction.

mechanisms for life span regulation, 4) roles of protein

Approaches by molecular genetics and comparative

kinases in cell cycle progression and regulation, 5)

genomics are taken with Arabidopsis and liverwort

growth factor signaling mechanisms in developmental(Marchantia polymorpha). In particular, the genetic

processes, 6) regulatory mechanisms for mammaliananalysis of Marchantia is unique and efficient as its

circadian clock.

phylogenetically basal position in land plant evolution,
haploid-dominant life cycle, and simple transgenesis.
Genome analysis of Marchantia is also conducted in thislaboratory.

http://www.signal.lif.kyoto-u.ac.jp/

22

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.plantmb.lif.kyoto-u.ac.jp/

Department of Applied Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency

Laboratory of Biosignals and Response■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

NAGAO, Masaya
KAMBE, Taiho
MIYAMAE, Yusaku■ Main theme

Molecular and cellular biological studies on

Bio-prospecting, a research strategy searching

totipotency in plant cells have been carried out in thisfor compounds that possess beneficial activity forlaboratory using in vitro cultured cells and transgenic

health from natural sources, is one of the projects inplants. Especially, cell/organ differentiation fromthis laboratory. Especially, at present, compounds thatundifferentiated cells, functional differentiations,prevent hepatic fibrosis and replication of hepatitis C

e.g. secondary metabolite production, such as

virus are the main targets of our bio-prospecting.

biosynthesis of isoquinoline alkaloids, oxygen evolving

We are also studying how organisms perceive

complex in photosystem II, cyclic electron transfer

environmental signals and transduce these signals intoand gene regulation in chloroplast, have beenchanges in gene expression, focusing mainly on theinvestigated to understand the totipotent functions inmolecular and cellular basis of zinc metabolism (suchplant cells. Development of novel genetic engineering

as uptake, storage, delivery, and maintenance oftechniques such as genome editing, metabolic

metal concentration in cells) in mammal.

engineering and synthetic biology of secondary
metabolism for industrial application have been also
investigated.

Stimulation of lipid accumulation by plant extracts

Zinc transporters in mammals
ENTEROCYTE
ZnT4

Zn2+

ZIP4

GENERIC CELL

ZnT1

Zn2+

ZIP5

2+

Zn

ZnT1

Zn2+

ZnT2, 4

ZIP1~3, 6, 8, 10, 14

Zn

Endosomes/Lysosomes

2+

Zn2 +

ZIP7, 9, 13
MTF-1
ZnT1

Zn

ER/
Golgi

ZnT4~7
TGN

MT

2+

ZIP5

Mt-I/II, Znt1 etc

ACINAR CELL
Glutamate vesicles

2+

Zn

ZIP3
ZnT2, 4MAMMARY EPITHELIAL CELL

http://www.callus.lif.kyoto-u.ac.jp/

ZIP4

ZnT5, 8

ZnT3

Insulin granules

β CELLNEURON

http://www.seitaijoho.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

23

Division of Integrated
Life Science

Laboratory of Applied Molecular Microbiology

Laboratory of Molecular Biology ofBioresponse■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor

FUKUZAWA, Hideya
YAMANO,Takashi
KAJIKAWA,Masataka■ Main theme

KATAYAMA, Takane
MASUDA, Seiji■ Main theme

We are focusing on the molecular bases of biological

The aim of our laboratory is to understand thefunctions of microalgae contributing to production of food,

fundamental life processes of microbes and human,

biofuel and industrial materials, and also to environmental

and to develop food- and health-oriented application

remediation by photosynthesis. Especially we employ

research. The research activities mainly include (1)a green alga, Chlamydomonas reinhardtii, as a model

elucidation of the molecular mechanism underlying

eukaryotic photosynthetic microorganism using its genomic

symbiosis and co-evolution between gut microbes

information, mutants, and molecular/biochemicaland host, and (2) elucidation of the mechanism oftechniques.

mRNA processing, export and quality control in the

The current projects are

nucleus in human and its industrial applications.

(1) Molecular characterization of the carbon-concentrating(1) Recent studies have shown that the consortium

mechanism supporting photosynthetic carbon fixation,of gut microbes exerts a considerable influence on

biofuel production, and cell proliferation,

host health. Most researchers approach this topic from

(2) Elucidation of regulatory systems controlling“host” side using a mouse model, but we believe thatphotosynthesis and carbon metabolisms by sensing

approaches from “microbe” side are equally needed

environmental factors including changes of levels in CO2

to understand the symbiosis between them. To thisconcentration, light and nutrient starvation.

end, we are genetically and enzymatically analyzing(3) Metabolic engineering for production of industrial

unique metabolic pathways in gut microbes, which

important fatty acids, glycerolipids and carbohydrates.

should uncover the cross-kingdom communications(4) Molecular control and signaling of sexual reproduction
by nutrient starvation.

between bacteria and host in intestine.
(2) The main projects are (i) the role of TREX and
AREX, which couple transcription and export ofmRNA, (ii) the molecular mechanism of RNA quality
control in the nucleus, (iii) cell engineering for theprotein production using mRNA export mechanism inmammalian cells to apply to industrial applicationsand (iv) identifying the active compounds which
inhibit the mRNA matabolism to apply to medical
care.

http://www.molecule.lif.kyoto-u.ac.jp/

24

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.bunshioutou.lif.kyoto-u.ac.jp/

Department of Responses to Environmental Signals and Stresses

Laboratory of Plant Developmental Biology

Laboratory of Plasma Membrane andNuclear Signaling■ Professor■ Associate Professor■ Assistant Professor■ Associate Professor■ Assistant Professor

ARAKI, Takashi
ENDO, Motomu
NIWA, Masaki■ Main theme

YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

We are interested in molecular mechanisms

Our laboratory studies dynamic properties ofunderlying plant’s responses to environment. Plants

proteins and large protein complexes in cellular

have evolved plastic developmental programs

environments by using a variety of techniqueswith both genetic and epigenetic basis to adapt

in biochemistry, molecular biology and cellular

their sessile mode of life to changing environment.

biology, in combination with nano-technology andUsing an angiosperm, Arabidopsis thaliana andcomputational simulation. Specific research topics

a liverwort, Marchantia polymorpha as model

include:systems, we have been investigating (1) regulation(1) U n d e r s t a n d i n g m o l e c u l a r m e c h a n i s m a n dof growth phase transition (especially, flowering) inbiophysical background of mitotic chromosome

response to environmental signals, (2) long-distancecondensation

systemic signaling in the control of development, (3)(2) S i n g l e - m o l e c u l e i m a g i n g o f h i g h e r - o r d e rtissue-specific roles of circadian clock for optimalarchitectures of DNA, RNA and various

environmental responses, (4) sexual reproduction
processes, and (5) origin and evolution of regulatory
systems for plastic development.

nucleoprotein complexes(3) N o n - i n v a s i v e i m a g i n g o f m e m b r a n e a n dcytoskeletal dynamics by fast-scanning atomic
force microscopy(4) Understanding physical and chemical mechanismsof subunit assembly and disassembly of nuclear
pore complex(5) Structural dynamics of flexible and repetitive
proteins in intracellular environments and molecular
crowding

http://www.plantdevbio.lif.kyoto-u.ac.jp/

http://www.chrom.lif.kyoto-u.ac.jp/english/index.html

DIVISION OF INTEGRATED LIFE SCIENCE

25

Division of Integrated
Life Science
Department of Molecular and Developmental Biology
D

Laboratory of Genome MaintenanceLaboratory of Nanobiology■ Professor■ Professor

MATSUMOTO, Tomohiro■ Main theme

HARADA, Yoshie■ Main theme

The spindle checkpoint, our major research

We are developing novel single-molecule imaging

subject, is a surveillance mechanism to regulatetechniques to investigate dynamic processes

cellular apparatus for compliance with this rule. It is aof intracellular substances and DNA-protein

unique negative feedback that converts/amplifies ainteractions related to genome DNA maintenance.

physical signal sensed by kinetochores (attachment of

To characterize dynamic processes of DNA-protein

the spindle and/or tension) and regulates the timing

interactions, we are constructing Zero-modeof the sister chromatid separation. Mad2, a signal

waveguides. This method enables us to visualize

carrier of this feedback, plays a vital role in the spindle

single-molecule fluorescence at high concentration.

checkpoint. It is specifically localized at unattached

Using Zero-mode waveguides, we focus on

kinetochores that are the origin of the checkpoint

characterizations of proteins involved in homologous

signal. Mad2 targets CDC20 and inhibits its activity torecombination or epigenetics such as RuvAB protein

promote sister chromatid separation. We study Mad2,

complex or nucleosome binding proteins. We are alsoa central player of the spindle checkpoint, to reveal

developing a novel method for the selective imaging

mechanisms, which regulate the activity of Mad2.

using nanodiamonds. Using this novel method, westudy dynamic processes of intracellular substances ofinterest.

http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index.htm

26

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.harada.icems.kyoto-u.ac.jp/en/

Department of Molecular andCellular Biology

Laboratory of Developmental
Neurobiology

Laboratory of Molecular Cellular
Immunology■ Professor■ Professor■ Associate Professor

KENGAKU, Mineko■ Main theme

FUJITA, Takashi
KATO, Hiroki■ Main theme

Neurons in the mammalian brain are orderly

Virus infections, such as influenza A epidemic andarranged in cortices and nuclei for integration into

Chronic Hepatitis C virus infection are still important

specific neural circuits. During development, neurons

diseases and outbreaks of newly emerging viruses are

directionally migrate from the birthplace to theirserious problems for modern society. Higher animals,

destination within the cortex, and then arborize

including humans, are genetically equipped withwell-patterned dendrites and axons to contact

mechanisms, collectively known as innate immunity,with their specific synaptic counterparts. The major

to counteract viral infections. During the course ofgoal of our research is to clarity the mechanisms ofreplication, many viruses generate double-stranded

cortical lamination and functional wiring of neurons(ds) RNA, which is virtually absent in normal cells andin the brain. We seek to identify the molecularlikely serves as a "foreign molecule" in cells. An RNA

signals regulating neuronal migration and dendrite

helicase, RIG-I, functions as a sensor for viral dsRNA. RIG-I

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n g

is composed of three domains : a Caspase recruitment

techniques for real-time observation of molecular anddomain (CARD), a DExD/H helicase domain, and acellular dynamics of neuronal migration and dendrite

C-terminal domain (CTD) (Figure). CTD senses viral dsRNA

patterning to discover novel phenomena and rules in

produced in the cytoplasm, leading to a conformational

neuronal motility in the developing brain.

change. This conformational change releases CARD,
which signals to downstream, resulting in the activation

Molecular Layerof genes including those for type I interferon and other

Purkinje Cell Layer

cytokines. The purpose of our project is to clarify the

Granule Cell Layer

molecular mechanism underlying the antiviral innate

White Matter

Granule Cell

immunity regulated by RIG-I, and to develop new
diagnostic and therapeutic means for viral infections.
Purkinje Cell
Cerebellar nuclei

http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden2012/
http://www.kengaku.icems.kyoto-u.ac.jp/

English/index.html

DIVISION OF INTEGRATED LIFE SCIENCE

27

Division of Integrated
Life Science

Laboratory of Developmental Dynamics■ Professor■ Associate Professor■ Assistant Professor

KAGEYAMA, Ryoichiro
OHTSUKA, Toshiyuki
KOBAYASHI, Taeko■ Main theme
We a n a l y z e t h e m o l e c u l a r m e c h a n i s m o fembryonic development by using the mostadvanced methods such as imaging, optogenetics
and transgenic mouse technologies. We evaluate
mathematical modeling by using transgenic mice andseek to understand the principles of developmental
dynamics.

http://www.virus.kyoto-u.ac.jp/Lab/Kageyama/index_English.html

28

DIVISION OF INTEGRATED LIFE SCIENCEDIVISION OF SYSTE
SYSTEMIC LIFE SCIENCEThis division consists of 17 laboratories including 5 cooperative laboratories from Institute for Virus Research, Graduate School of Medicine,
Institute for Frontier Medical Science and RIKEN Center for Development
Biology. Thirty-five graduate students are accepted in the Master's Program annually, and 14 in the Doctoral Program. In this division, education
and research are focused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental
approaches are taken with viruses, microorganisms, cultured cells andanimals. We pursue education and research to elucidate
date the molecularmoleaspects of Systemic Life Science.

Division of SystemicLife Science
Department of Molecular and System Biology
D

Laboratory of Single-Molecule Cell Biology

Laboratory of Bioimaging andCell Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Assistant Professor■ Assistant Professor

WATANABE, Naoki
YAMASHIRO, Sawako
MIZUNO, Hiroaki■ Main theme

MATSUDA, Michiyuki
IMAJO, Masamichi
KOMATSU, Naoki■ Main theme

Our laboratory aims at bridging the gap between

We are visualizing the growth signal transduction

molecular activities and cell physiology in life systems.

cascades in living cells by using biosensors based on

We are trying to visualize signal transduction and cell

the principle of Foerster resonance energy transfer

structure remodeling processes directly in living cells(FRET). These FRET videos are processed to extract

by fluorescence single-molecule microscopy andparameters that characterize the property of eachrelated high-resolution imaging techniques.

signaling molecule. We use these parameters
obtained in living cells to build kinetic simulation
models of growth signal transduction cascades.We
are also developing transgenic mice expressing FRET
biosensors to observe the signaling status in living micewith two-photon excitation microscopes.

http://www.fret.lif.kyoto-u.ac.jp/

30

DIVISION OF SYSTEMIC LIFE SCIENCEDepartment of Animal Development and Physiology

Laboratory of Molecular andCellular Biology

Laboratory of Immunobiology■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Lecturer

YONEHARA, Shin
SAKAMAKI, Kazuhiro
LEE, Kyung-Kwon■ Main theme

INABA, Kayo
TAKAHARA, Kazuhiko■ Main theme

Apoptosis, or programmed cell death, plays an

Our interest is the induction and control ofimportant role in many biological processes, including

i m m u n i t y . We f o c u s o n d e n d r i t i c c e l l s ( D C s ) ,embryogenesis, development of immune system,

which are a primary antigen-presenting cell in themaintenance of tissue homeostasis, and elimination

immune system. Our current major topics includeof virus-infected and tumor cells. We found cell

the control of DC functions using several types of

surface Fas antigen (Fas), which can directly mediate

glycolipids, resulting in both immune activation andapoptosis-inducing signals into cells by stimulation with

suppression. We are also interested in functions ofagonistic anti-Fas mAbs or Fas ligand (Yonehara S, etlectin molecules expressed on DCs/macrophages thatal., 1989; Itoh N, et al., 1991). Our main research project

recognize polysaccharides on pathogenic agents.

is to understand the intracellular signal transduction

The study includes analyses of interaction between

mechanism of cell death including apoptosis andpolysaccharides and lectins, and subsequentcaspase-independent novel types of cell death,cellular and systemic responses in co-operation withand the biological significance/physiological role of

TLR signaling. In this study, we found that certain

cell death and cell death-regulating molecules. In

lectin-polysaccharide interaction induced immune

conjunction with these studies, we have been trying tosuppressive environment, ameliorating excessive andidentify other cell death-related molecules that playlethal inflammation. By these studies, we would like toa key role in embryogenesis, tumorigenesis or immune

develop new methods to control immune system.

system. Investigations of molecular mechanisms andMouse lectins expressed on DCs/macrophages

physiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

http://www.fas.lif.kyoto-u.ac.jp/

http://zoo.zool.kyoto-u.ac.jp/imm/

DIVISION OF SYSTEMIC LIFE SCIENCE

31

Division of SystemicLife Science

Laboratory of Molecular Cell Biology andDevelopment（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Visiting Professor（Imai Laboratory）■ Visiting Associate Professor■ Main theme■ Main theme

IMAI, Takeshi

We seek to explore the molecular mechanisms

The mammalian central nervous system is composed

underlying the organization of cells into highly orderedof enormous numbers of neurons. How do these neurons

structures in the developing brain. The vertebrate

establish their identity and form functional neuronalbrain comprises a considerably larger number ofcircuitries? To address this question, we are studying theneurons arranged in a vastly complex functional

mouse olfactory system as a model system. In the mouse

network, which develops from a single layer ofolfactory system, odorants are detected by ~1,000 types

epithelial cells that function as neural stem cells.

of olfactory sensory neurons, each expressing a single

Those cells initially proliferate to expand the stem cell

type of odorant receptor. The olfactory bulb, the primary

population. Subsequently neural stem cells undergo

olfactory area of the brain, receives inputs from olfactory

asymmetric cell divisions to generate self-renewing

sensory neurons through 1,000 sets of glomeruli. Theseand differentiating daughter cells. Thus the transition

inputs are then processed in the olfactory bulb circuits

from the proliferative phase to the neurogenic

and are then sent out to the olfactory cortex. These

phase is critical for the determination of the brain

complex neuronal circuits emerge in an autonomous

size. Asymmetric cell division also appears to play an

fashion based on cell-cell interactions and neuronalessential role in the neuronal production. However,activity after birth, rather than by strict genetic programs.

little is known about mechanisms controlling those

Using the olfactory bulb as a model system, we are

critical events in the brain development.

trying to understand simple rules behind the formation of

We use both an invertebrate (Drosophila) andcomplex neuronal circuitry.

vertebrate (mouse) model systems to understandprinciples for the brain organization such as:
1. How the timing of the proliferative to neurogenictransition is determined in the brain development.
2. How neural stem cells simultaneously generate
self-renewing and differentiating cells.
3. H o w c e l l p o l a r i t y c o n t r i b u t e s t o c o n t r o lasymmetric cell division of neural stem cells.
4. How diverse neuronal types are generated froma single neural stem cell over time.
5. How the global brain architecture is dictated by
the structure and activity of neural stem cells

Dendrite wiring of mitral cells in the mouse olfactory bulb.

http://www.cdb.riken.jp/en/research/laboratory/matsuzaki.html

32

DIVISION OF SYSTEMIC LIFE SCIENCE

http://imai.uijin.com/english.html

（Kitajima Laboratory）■ Visiting Associate Professor

KITAJIMA, Tomoya■ Main theme
In order to maintain genetic information acrossgenerations, cells must segregate chromosomes
equally to daughter cells during mitosis. Meiotic
divisions of the mammalian oocyte, however, are
known to exhibit a higher frequency of errors inchromosomal segregation than in other cell types.
Moreover, oocyte chromosomes behave in ways
distinct from those in other cells, and these uniquedynamics may provide insights into novel mechanisms
for chromosome segregation. Taking advantage of
our established live imaging technologies, we seek
to conduct detailed and comprehensive analysesof the chromosome dynamics and the molecularmachinery that underlies chromosome segregation
during mammalian oocyte meiosis. We also seek to
identify the causes behind age-related increases inchromosome segregation errors during oocyte meiosis.

（Kuranaga Laboratory）■ Visiting Associate Professor

KURANAGA, Erina■ Main theme
The development of multicellular organisms
involves the collective effect of multiple events at
the level of the individual cell, such as proliferation,differentiation, adhesion, and migration. Programmed
cell death, for example, is a process by which cells
are selected for death at set times in development,
allowing for the sculpting of tissue, and is used in theadult organism to maintain homeostasis by eliminating
cells that have developed abnormalities. Perturbations
in cell death signaling can thus affect an organism’s
physiological stability, and result in developmental
defects, tumorigenesis, or neurodegenerative disease.
Cell death plays an important role in maintaining thecellular society not only by eliminating unneeded
cells at given sites and stages, but in other functions,such as regulating the proliferation and migration ofneighboring cells, as well. Such cellular behaviors giverise to cell networks capable of organizing into tissues,
the study of which requires a experimental approachto spatiotemporal information in living systems, such as
can be obtained through the real-time live imaging of
biological phenomena.
We h a v e c h o s e n t h e f r u i t f l y D r o s o p h i l amelanogaster as our primary research model, seeking
to take advantage of its utility in developmental
studies and wealth of genetic data in studying
the coordination of morphogenesis through liveimaging and genetic screens. We especially focus
on the morphogenetic processes that involve cellularmigration and cell death, such as the looping
morphogenesis of fly male ter minalia and theabdominal epidermis rearrangement, to understandthe principles for the morphogenetic dynamics asfollows,
1) The physiological roles and regulating
mechanisms of cell death during development
2) Non-autonomous mechanisms to induce cell
death during regeneration
3) Mechanics and molecular mechanisms for
unidirectional motion of collective cellular movement
Figure: Caudal view of developing
fly male ter minalia expressing DECadherin:GFP

Prometaphase belt of chromosomes

http://www.cdb.riken.jp/en/research/laboratory/kitajima.html

http://www.cdb.riken.jp/en/
research/laboratory/kuranaga.html

DIVISION OF SYSTEMIC LIFE SCIENCE

33

Division of SystemicLife Science
Department of Signal Transductions
D

Laboratory of Molecular Neurobiology

Laboratory of Genetics■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Lecturer

NEGISHI, Manabu
KATOH, Hironori
OINUMA, Izumi■ Main theme
Outline of Teaching Activities

IGAKI, Tatsushi
OHSAWA, Shizue■ Main theme
Our research focuses on the molecular basis of

The laboratory provides seminars which review andcell-cell communication that governs tissue growth,

discuss recent progress in molecular mechanisms of

homeostasis, and cancer. We take advantage of theneuronal functions

powerful genetics of Drosophila.

Outline of Research Activities
The main themes of research in this laboratory■ Research subjects:
1. Mechanism of cell competition

are the molecular mechanisms underlying neuronal

2. Genetic basis of tissue growth regulation

network formation and neuronal signal transductions.

3. Molecular basis of tumor progression and

1. Neuronal functions and signal transductions ofmetastasis

GTP-binding proteins
2. Molecular mechanisms for axon guidance
3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formation

Left:Polarity-deficient cells (green; losers) are eliminated from
epithelium by wild-type cells (magenta; winners) through cellcompetition.
Right:Malignant tumor cells (magenta) are invading andmetastasizing from the eye disc to the brain (blue) in Drosophila
larva.

http://www.negishi.lif.kyoto-u.ac.jp/e/Top.html

34

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/genetics/

Department of Functional Biology

Department of Biostudies and Society

Laboratory of Functional Biology

Laboratory of Science Communication
and Bioethics■ Professor■ Associate Professor■ Assistant Professor■ Assistant Professor

KAKIZUKA, Akira
IMAMURA, Hiromi
SASAOKA, Norio
ABE, Megumi■ Main theme■ Main theme
Using animal models of human diseases, such asneurodegenerations, cancers, and obesity-relateddiseases, and using metabolite imaging techniques,
we aim to elucidate molecular bases of such diseases
and develop new strategies to cure or prevent them.
One of the main features of life science research

In our laboratory, we aim to identify essential issues
in the interface between biostudies and the society,and to propose possible actions or solutions.
Currently, we are focusing on the following threeareas.
1.Theoretical and practical analysis of science
communication.

in the coming years will be that the results obtained

In addition to organizing practical activities suchfrom fundamental research should ideally beas "Genome Square", a public event (http://hiroba.

directly connected to the good of society. From thisgenome.ad.jp/ in Japanese language only), we

standpoint, in addition to handling topics with highanalyze the effects and significance of sciencescientific significance, we aim to contribute to thecommunication. This includes the communication

development of treatments for neurodegenerative

between scientists and the general public, and thatdiseases, cancers, and obesity-related diseases fromamong scientists and scientific communities.

our research results.

2. Analysis of bioethical issues in biostudies.

We hold the same view on scientific education,

We study ethical, legal and social implications ofand through training individuals to communicate theirbiostudies such as human genome research andideas logically yet effectively, as well as by nurturing
their creativity, in addition to strengthening their

human stem cell research.
3. Analysis of modern history of biostudies.

practical research skills, we aim to cultivate opinion

We analyze the development and changes ofleaders standing at the core of life science research inbiostudies in the last 20 to 30 years through literaturethe 21st century.

surveys and interviews with scientists.

http://www.funcbiol.lif.kyoto-u.ac.jp/

DIVISION OF SYSTEMIC LIFE SCIENCE

35

Division of SystemicLife Science

Laboratory of Science Communication

Laboratory of Bioeducation■ Professor■ Professor

HEJNA James Alan

■ Main theme
Our laboratory engages in the development
and implementation of new approaches to the

CHISAKA,Osamu■ Main theme
Our laboratory has been trying to improve study
materials on biology.

inter nationalization of science education andcommunication, based on principles of active
learning. The particular challenges we are addressing
often involve overcoming the differences in culture
and pedagogical traditions between Japaneseand Western societies, most potent obstacles that
impede communication. Our efforts are chiefly
in the educational arena, aimed at training thenext generation of scientists to communicate theirknowledge and expertise not only to the international
scientific community but locally to the citizens who
ultimately support basic research. Our activities entail
the following:
1. Increasing the exposure of Japanese students toforeign peers. We are forging new partnerships
with foreign universities to foster joint courses,
using live Internet connections, with active
student participation in English.
2. Establishing partnerships with foreign universities
to encourage short-term reciprocal exchangeof graduate students for collaborative research.
3. Expanding the opportunities for students topresent their research in English to a broad
audience.

36

DIVISION OF SYSTEMIC LIFE SCIENCE

1. Introduction of moder n topics into study
materials on biology
2. Introduction of active learning methods into
biology lectures in English
3. Exploitation of new biology lab course protocols
and materials

Department of Mammalian Regulatory Network

Laboratory of Cell Regulation and
Molecular Network

Laboratory of Viral Oncology■ Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SUGITA, Masahiko
MORITA, Daisuke■ Main theme

TOMONAGA, Keizo
HIJIKATA, Makoto
HONDA, Tomoyuki■ Main theme

Full attention of this laboratory has been

The researches carried out in our laboratory are

directed to previously unappreciated aspects offocused on several RNA viruses, including bornavirus,

the acquired immunity that we call “lipid immunity”.

influenza virus and hepatitis C virus. All our projects

Unlike conventional MHC molecules that present

aim to understand the fundamental mechanisms ofprotein-derived peptide antigens, molecules of thethe replication and pathogenesis of these viruses.

human group 1 CD1 family (CD1a, CD1b, CD1c)

We are investigating the replication and persistent

mediate presentation of “lipid” antigens to specific T

mechanism of the bornavirus in the cell nucleus.

lymphocytes. In addition, we have recently identified

The understanding the biological significance of thea novel lineage of antigen-presenting molecules,

endogenous element of bornaviruses in mammaliantermed LP1, capable of mediating presentation of

genomes is one of the main focuses of bornavirus“lipopeptide” antigens. By taking cell biological,

researches. We also aim to develop a novel RNA virus

immunological and lipid chemical approaches, thisvector using bornavirus, which can express stablylaboratory wishes to establish a molecular and cellularfunctional small RNAs. In Influenza virus researches

basis for lipid immunity and determine how CD1 andwe examine the response of host cells to the virus

LP1 have been evolved to function critically in host

infection. The understanding of the moleculardefense. An important extension of this research is amechanism of tumorgenesis caused by hepatitis

challenge for developing a new type of lipid-based

C virus infection is also the main purpose of ourvaccines against cancer and microbial infection.

laboratory.

http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

http://www.virus.kyoto-u.ac.jp/virus/ganvirus.html

DIVISION OF SYSTEMIC LIFE SCIENCE

37

Division of SystemicLife Science

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Assistant Professor■ Assistant Professor■ Professor

TOYOSHIMA, Fumiko
MATSUMURA, Shigeru
ODA, Yukako■ Main theme

SHIMIZU, Akira■ Main theme

Stem cells in adult tissues exist in a quiescent

Major goal of research in this laboratory is tostate. When they are needed in tissue homeostasis

understand molecular and cellular mechanisms

o r r e p a i r, t h e y e x i t q u i e s c e n t s t a t e , u n d e r g o

underlying highly systemic functions of living things,

symmetric/asymmetric cell division, and give rise tosuch as immune and neural systems. For this purpose,

differentiation-committed progenitor cells. Our groupstructure and regulation of genetic information

seeks to explore the molecular mechanisms underlying

responsible for such systemic functions are beingoriented cell division, stem cell quiescence, and cell

analyzed using model animals, for example,

fate determination. We want to know how stem cells

transgenic or gene disrupted mice. Our research is

response to the changes in the balance of body

focused on the following subjects:

homeostasis during life events, including pregnancy.

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n d

Our research is focused on the following subjects:

regulation of chromatin modification, gene
expression, gene rearrangements and RNA

1, Oriented cell division in culture cells and mouse
tissues.
2, Quiescence VS Proliferation/differentiation ofstem cells.
3, Proliferation and differentiation control of adultstem cells during pregnancy.

processing during lymphocyte differentiation.
2. Making and characterization of model miceof immunodeficiency or autoimmune byintroduction of, or targeted disruption ofinterleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for
lymphocyte mobility and formation of immuno-.

microenvironment during development andimmune reaction.

http://www.virus.kyoto-u.ac.jp/Lab/toyoshima.html

38

DIVISION OF SYSTEMIC LIFE SCIENCE

Laboratory of Bio-functions Biomaterials■ Professor■ Associate Professor■ Assistant Professor

TABATA, Yasuhiko
YAMAMOTO, Masaya
JO, Jun-ichiro

Laboratory of Cellular and Molecular
Biomechanics■ Professor■ Associate Professor■ Assistant Professor

ADACHI, Taiji
INOUE, Yasuhiro
KAMEO, Yoshitaka■ Main theme
The main objective of our department is to■ Main theme

proceed the research and development of methods,

Our research group aims to clarify the mechanisms

procedures, and technologies applicable to basic

by which cells sense mechanical stimuli and regulate

research of biology and medicine, and medicines

their activities in tissue adaptation, regeneration(therapy, diagnosis, and prophylaxis) from theand stem cell differentiation in morphogenesis.

viewpoint of material sciences. The biomedical

To better understand the mechano-regulation ofmaterials (biomaterials) to use in the body and tothese dynamical processes through the complex

contact biological substances are being designed andhierarchical structure-function relationships, bridging

created from biodegradable and non-biodegradable

spatial and temporal scales from microscopic

materials. Our goal is not only to carry out researches

molecular/cellular activities to macroscopic tissueof tissue regenerative therapy (tissue engineering, cell

behaviors is very important. Based on multiscaletransplantation, cell research, and drug discovery),biomechanics, our group is involved in the integrated

drug delivery system (DDS), biomedical engineering,biomechanics and mechanobiology researches ofand stem cell technology, but also put the researchmodeling and simulation combined with experiments,

results to clinical and practical uses.

focusing on mechano-biochemical couplings in thesystem dynamics.

■ Research contents• Research and development of cell scaffolds and1. Biomechanics and mechanobiology studies on stem

local release of bioactive drugs with biomaterials

cell differentiation, morphogenesis, and remodelingfor regenerative medicine (regenerative therapy
and research)• Research and development of biomaterials for
medical development• Research and development of drug delivery
system (DDS) for drug therapy, diagnosis, andprophylaxis• Research and development of biomaterials forstem cells technology and drug discovery

in tissue development and regeneration.
2. U n d e r s t a n d i n g m e c h a n i s m s o f t i s s u edifferentiation and regeneration emerged frommulticellular dynamics.
3. Multiscale modeling and simulation of actin
filament dynamics in cell migration.
4. Elucidation of mechano-biochemical couplingmechanisms in mechanosensory cells.
5. Nano- and microengineering of artificial systems
combined with biomolecular and cellular systems.

Multiscale computational
biomechanics on tissuemorphogenesis

http://www.frontier.kyoto-u.ac.jp/te02/index_en.html

Nano-mechanicalmeasurement of biomolecules

http://www.frontier.kyoto-u.ac.jp/bf05/index-e.html

DIVISION OF SYSTEMIC LIFE SCIENCE

39

Organization (2015)
DIVISION OF INTEGRATED LIFE SCIENCE
Department
Gene Mechanisms

Cell andDevelopmental Biology

Plant Gene andTotipotency

Applied Molecular
Biology

Responses toEnvironmental Signals
and Stresses

Laboratory
Chromosome
Transmission
Gene Biodynamics
Cell Cycle Regulation
Cell Recognition and
Pattern Formation

Professor

Associate Professor

TAKEYASU,Kunio

NAKASEKO,Yukinobu

Signal Transduction

NISHIDA,Eisuke

Lecturer

Assistant Professor

SHIRAISHl,Hideaki
ISHIKAWA,Fuyuki
UEMURA,Tadashi

Plant Molecular Biology KOHCHl,Takayuki
Molecular and Cellular
SATO,Fumihiko
Biology of Totipotency
Biosignals and
NAGAO,Masaya
Response
Applied Molecular
FUKUZAWA,Hideya
Microbiology
Molecular Biology of
KATAYAMA,Takane
Bioresponse
Plant Developmental
ARAKI,Takashi
Biology
Plasma Membrane
and Nuclear Signaling
Genome
MATSUMOTO,Tomohiro
Maintenance1

Molecular and
HARADA,Yoshie
Developmental Biology Nanobiology2*
Developmental
KENGAKU,Mineko
2
Neurobiology
Molecular and Cellular
FUJITA,Takashi
Immunology3
Molecular and Cellular Mammalian Molecular
Biology *Biology3
Developmental
KAGEYAMA,Ryoichiro
Dynamics3

NISHIHAMA,Ryuichi
ENDO,Tsuyoshi

SADAIE,Mahito
USUI,Tadao
HATTORI, Yukako
MIYATA,Yoshihiko
KUSAKABE,Morioh
YAMAOKA,Shohei
SUETSUGU,Noriyuki
IFUKU,Kentaro

KAMBE,Taiho

MIYAMAE,Yusaku
YAMANO,Takashi
KAJIKAWA,Masataka

MASUDA,Seiji
ENDO,Motomu

NIWA,Masaki

YOSHIMURA,Shigehiro

KUMETA,Masahiro

KATO,Hiroki

OHTSUKA,Toshiyuki

KOBAYASHI,Taeko*Cooperation Course 1) Radiation Biology Center, 2) Institute for Integrated Cell-Material Sciences (iCeMS), 3) Institute for Virus Research

DIVISION OF SYSTEMIC LIFE SCIENCE
Department

Laboratory
Professor
Single-Molecule Cell
WATANABE,Naoki
Molecular and System Biology
Biology
Bioimaging and Cell
MATSUDA,Michiyuki
Signaling
Molecular and Cellular
YONEHARA,Shin
Biology
Animal Development Immunobiology
INABA,Kayoand Physiology
Molecular Cell Biology
MATSUZAKI,Fumio7
and Development **Signal Transductions
Functional Biology

Molecular
Neurobiology
Genetics
Functional Biology

NEGISHl,Manabu

Associate Professo

SAKAMAKl,Kazuhiro

KAKIZUKA,Akira

Assistant Professor
YAMASHIRO,Sawako
MIZUNO,Hiroaki
IMAJO,Masamichi
KOMATSU,Naoki
LEE,Kyung-Kwon

TAKAHARA,Kazuhiko
IMAI,Takeshi 7
KITAJIMA,Tomoya 7
KURANAGA,Erina 7
KATO,Hironori

IGAKI,Tatsushi

ScienceCommunication and
INABA,Kayo
Bioethics
Biostudies and Society
Science
HEJNA,James Alan
Communication
Bioeducation
CHISAKA,Osamu
Cell Regulation and
SUGITA,Masahiko
4
Molecular Network
TOMONAGA,Keizo
Viral Oncology4
Cell Division and
TOYOSHIMA,Fumiko
4
Mammalian Regulatory Differentiation
Network *Genetic Information5
SHIMIZU,Akira
Bio-functions
TABATA,Yasuhiko
Biomaterials6
Cellular and Molecular
ADACHI,Taiji
Biomechanics6

Lecturer

OINUMA,Izumi
OHSAWA,Shizue

IMAMURA,Hiromi

Enomoto,Masato
SASAOKA,Norio
ABE,Megumi

MORITA,Daisuke
HIJIKATA,Makoto

HONDA,Tomoyuki
MATSUMURA,Shigeru
ODA,Yukako

YAMAMOTO,Masaya

JO,Jun-ichiro

INOUE,Yasuhiro

KAMEO,Yoshitaka*Cooperation Course 4) Institute for Virus Research, 5) Graduate School of Medicine, 6) Institute for Frontier Medical Sciences**Collaboration Course 7) RIKEN Center for Development Biology

Organization

41

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/access/Faculty of Medicine Bldg.F □RIKEN Center for Developmental Biology▼Laboratory of Moleculer Cell Biology
and Development

Laboratory of Bioimaging and Cell Signaling ▼South Campus Research Building for □Integrated Life Sciences / Building G

KYOTO

KOBE

Laboratory of Chromosome Transmission ▼Laboratory of Cell Cycle Regulation ▼Laboratory of Cell Recognition and ▼Pattern Formation
Laboratory of Plasma Membrane and ▼Nuclear Signaling
Laboratory of Molecular and Cellular Biology ▼Laboratory of Immunobiology ▼Laboratory of Molecular Neurobiology ▼Laboratory of Science Communication ▼Laboratory of Bioeducation ▼Graduate School of Biostudies (Oﬃce) ▼OSAKA

to Kokusai kaikan

Kitaoji St.

Science Frontier Laboratory □Laboratory of Functional Biology ▼Higashi-ichijo

Karasuma Imadegawa

Imadegawa St.

Kawaramachi St.

Faculty of Medicine Bldg.A □Kyoto Imperial Palace

Karasuma St.

Horikawa St.

Radiation Biology Center □Laboratory of Genome Maintenance ▼Marutamachi St.

Laboratory of Single-Molecule Cell Biology ▼Oike St.

Faculty of Pharmaceutical □Sciences Main Bldg.

Tozai Line

Shijo St.

Hankyu Ry.

to Osaka

Laboratory of Genetics ▼Gojo St.
Karasuma Line

Shitijo St.

to Osaka

Kyoto Sta.
Kintetu Line

to NaraKawabata St.

Marikoji St.

Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

Higashioji St.

1

Konoe St.

□ Institute for Virus Research Main Bldg.
▼ Laboratory of Molecular and Cellular Immunology▼ Laboratory of Developmental Dynamics▼ Laboratory of Cell Regulationand Molecular Network▼ Laboratory of Cell Division and Diﬀerentiation□ Institute for Frontier Medical Sciences (East Bldg.)
Kasuga St.

▼ Laboratory of Bio-functions Biomaterials▼ Laboratory of Cellular and Molecular Biomechanics□ Molecular Biology Research Bldg.
Faculty of Medicine Center for Genomic Medicine▼ Laboratory of Mammalian Molecular Biology▼ Laboratory of Viral Oncology▼ Laboratory of Genetic Information

42

Map & AccessNorth Campus Research Building □for Integrated Life Sciences
Laboratory of Gene Biodynamics ▼Laboratory of Plant Molecular Biology ▼Laboratory of Biosignals and Response ▼Laboratory of Applied ▼Molecular Microbiology
Laboratory of Molecular ▼Biology of Bioresponse
Laboratory of Plant ▼Developmental Biology

Faculty of Agriculture (Main Bldg.) □Laboratory of Molecular and ▼Cellular Biology of Totipotency

Faculty of Science (Bldg. No.2) □Laboratory of Signal Transduction ▼to Kurama
Eizan Ry.

Ke

ifu

ku

Lin

e.

2

Mt. Yoshida

Konoe St.

Jingu Marutamachi Sta.

Shirakawa
Shi
a St.

Hyakumanben

Kyodai
Seimon-mae

Keihan Line

Kamo River

DemachiYanagi Sta.

St.
egawa

Imad

anben

to Hyakum

2
North Campus

Hyakumanben

3
1

Imadegawa St.

Sanjo Sta.
to Yamashina

Gion Shijo Sta.

Higashioji St.

N

JR Lineto Tokyoto Osaka

Higashi Ichijo St

Main Gate

Higashioji St.

□ Institute for Integrated
Cell - Material Sciences(iCeMS) Research Bldg.
▼ Laboratory of Developmental
Neurobiology▼ Laboratory of Nanobiology

3
Konoe St.

Main Campus

Map & Access

43

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

kyomu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/