North Campus

Campus MAP

Graduate School of Agriculture
Graduate School of Biostudies● Gene Biodynamics

Graduate School of BIOSTUDIES Kyoto University● Plant Molecular Biology

Main Campus● Biosignals and Response● Applied Molecular Microbiology

Institute for Integrated
Cell-Material Sciences (iCeMS)● Molecular Biology of Bioresponse● Plant Developmental Biology● Symbiotic and Coevolutionary Mechanisms● Developmental Neurobiology● Biochemical Cell Dynamics

Faculty of Agriculture Main Bldg

● Multidisciplinary Biology● Molecular and Cellular Biology of Totipotency

Faculty of Medicine Bldg G
South Campus Research Bldg

Hyakumanben(Graduate School of Biostudies)● Chromosome Transmission● Cell Cycle Regulation

Hyakumanben● Cell Recognition and Pattern Formation

Imadegawa St.

Kyodai Nogakubu-mae● Ecosystems and Coevolution

Graduate School of

BIOSTUDIES

Kyoto University● Plasma Membrane and Nuclear Signaling● Immunobiology

St.

● Molecular Neurobiology

Higa
shioji● Science Communication● Graduate School of Biostudies(Office)Research Bldg. No.16● Signal Transduction

Science Frontier
Laboratory

Clock Tower● Functional Biology● Chromosome Function

Higashiyama higashi ichijo

and InheritanceFaculty of
Medicine Bldg A

t.

S
wa

a

● Single-Molecule Cellak
hirHigashi-Ichijo St.

Main Gate

Kyodai Seimon-mae

usBiology

Ky

Medicine Campus

Higashioji St.

Graduate School of
Pharmaceutical
Sciences Main Bldg.

● Genetics

Graduate School of Biostudies,
Radiation Biology Center

Graduate School of Agriculture
Graduate School of Biostudies● Genome Maintenance● Genome Stress Response● Cancer Cell Biology● Chromatin Regulatory Network

KonoedoriKonoe St.

Marikoji St.

Pharmaceutical
ScienceCampusInstitute for Life andMedical Sciences Bldg. No.2

Univ.
Hospital
East
Campus Kyodai● Aging and Infection Control● Brain Development and Regeneration

South Campus Research Bldg (Bldg. G)
Science Frontier Laboratory● Cell Division and Differentiation● Mechanosensory Physiology

Hospital-mae● Spatiotemporal Optical Control

NH 2

Institute for Life andMedical Sciences Bldg. No.3

N

N

● Ultrastructural Virology● RNA Viruses

Kasugakita St.

Institute for Life andMedical Sciences Bldg. No.1

Graduate School of Biostudies,
Radiation Biology Center● Cellular and Molecular Biomechanics

AccessKyobashi Station

Keihan Limited Exp. 47min

Demachiyanagi Station

Osaka Umeda Station

Hankyu Limited Exp. 41min

Kyoto Kawaramachi
StationOsaka Station

JR Special Rapid Service 29min

Osaka International
Airport (Itami)

Airport Limousine Bus 60min

Kansai International
Airport

JR Airport Express “Haruka” 75min

Kyoto
StationShijo Kawaramachi
StationKyoto city subway
For Kokusaikaikan
10min

Imadegawa
StationIn front of a Kyoto station

N

HN

NH 2

Kyoto city bus(201, 31) 20min
Karasuma
Imadegawa

Kyoto city bus(201) 15min

YoshidaCampus

O

N
H
O
CH 3

HN

Student Affairs Section

Email kyomu@adm.lif.kyoto-u.ac.jp【Other Inquiries】

General Affairs Section

https://www.lif.kyoto-u.ac.jp/e/N
H

N

Kyoto city bus(206) 30min

Graduate School of Biostudies Kyoto Univ. 【Inquiries concerning entrance examinationand "Global Frontier in Life Science”】

Phone 075-753-9221 FAX 075-753-9247
Email soumu@adm.lif.kyoto-u.ac.jp

O

H 2N

20min Walk

Contact

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

N
H

N

O

N
H

2024

Graduate School of BIOSTUDIES,
Kyoto University

Challenge the mysteries of life!
Life science is the study that tries to understand

The Graduate School of Biostudies (GSB) was“the mechanism of life” . The mechanism of life canestablished in April 1999 as Japan’ s first independent

be described as the rules of all life phenomena that

graduate school for life sciences with the aim ofhave been created over the 4.6 billion years since thepromoting world-leading life science researches andbirth of the earth. The rules of life phenomena are

fostering human resources beyond the traditional

unbelievably amazing. For instance, the genomic DNA

framework of Science, Agriculture, Pharmaceuticalin a cell is automatically and accurately duplicated in

Sciences, and Medicine. Since then, for the past 24

S phase, and then divides into two cells on its own.

years, leading researchers in various fields of life

When the sperm and egg are fertilized, the fertilized

sciences have led their laboratories and achieved

egg begins cell division automatically, causing

world-leading discoveries together with students anddifferentiation, proliferation, migration, and cell deathstaffs. In 2018, to further expand our research scope

precisely in a spatio-temporal manner andand educational area, the Radiation Biology Centerautomatically creates the exact individual animal. It is

and the Research Center for Dynamic Living Systems

as if life is defying even the second law ofwere established. We also establishedthermodynamics, a major principle of the universe. In

industry-university joint laboratories to promote social

fact, there is much we do not understand about how

implementation of research results. In April 2023, wesuch a mysterious phenomenon occurs. Yes, there

launched the Center for Living Systems Information

are many life phenomena that we take for granted in

Science (CeLiSIS), which is a developmental

textbooks, but the details of their rules are surprisingly

reorganization of the Research Center for Dynamic

unknown. Moreover, important life phenomena that

Living Systems. CeLiSIS will promote new researches

were previously unknown or overlooked are beingthat will lead data-driven life science, as well as create

discovered every year. Thus, life science is truly aa university-wide hub for fostering “two-way players”

treasure trove of research. On top of that, a single big

who can simultaneously acquire big data throughdiscovery in life science can change the world

experimental science and perform information

instantly. In fact, we have just witnessed one suchanalysis, thereby playing a leading role in the digital

example with the development of an mRNA vaccine

transformation in life sciences.

against COVID-19, which was resulted from the latest
basic research. Of course, life science is not only for

In addition, the GSB offers various programs tocuring human diseases. The discovery of new

support students’ research and education globally,mechanisms of life opens up the possibility ofsuch as remote lectures with overseas universities, asignificant contributions to the welfare and happinessprogram for sending students abroad, internationalof humankind, and even the earth itself, through its

student seminars organized by students, a program toapplication. Above all, the pleasure and excitement of

support international students, and a system fordiscovering a new mechanism of life is incomparable

transferring credits and promoting joint researches

to anything else. You may be moved by the precision

through inter-university agreements. We invite you toof life, bow down in awe at its mystery, and think ofjoin us and challenge the mysteries of life at the GSB.

the evolutionary history of living systems. If you

Beyond that, an exciting life far beyond yourpublish it in a paper to the world, your discovery will be

expectation may await you!

recorded forever as the knowledge of humankind. I
believe that life science is so interesting and excitingthat we do not even need to consider about the major
principles of the universe!

Dean,

IGAKI, TatsushiG r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,MISSIONS of our GRADUATE SCHOOL

1

Provide education for
pursuing the new biostudies
at the world's top level
To meet the demands of the industry,college, research institutes andadministrative organizations, individuals are
educated in the life sciences and master thetechniques for the society needs.

2

Train individuals to apply the new life
sciences for the protection of the global
environment and for human welfare
Integrate the knowledge and technology inthe old fields of science, agriculture,
medicine and pharmacology, and nurtureindividuals who can contribute to thehuman society in the 21st century.

K y o t o

Admissions Policy of the Graduate School of Biostudies
Master’ s Program

Doctoral Program

As an advanced discipline that holds the key to the future of humankind, the life

As an advanced discipline that holds the key to the future of humankind, the life

sciences today are undergoing a major evolutionary change. In response to thissciences today are undergoing a major evolutionary change. In response to thisglobal trend, the Graduate School of Biostudies was founded in 1999 as Japan’ s

global trend, the Graduate

first independent graduate school focused on the life sciences with the objective

School of Biostudies was founded in 1999 as Japan’ s first independent graduateof building a world-class center for research and developing individuals who canschool focused on life sciences with the objective of building a world-classlead the life sciences field into the next generation. Our school has engineered acenter for research and developing individuals who can lead the life sciences

true fusion of cutting-edge areas in several existing fields. By harnessing thefield into the next generation. Our school has engineered a true fusion ofcommon language of “cells, molecules, and genes” that together form thecutting-edge areas in several existing fields. By harnessing thefundamental principles of life, we have developed an integrated understanding of3

diverse life forms and the environments they help shape, and have launched

Nurture individuals who canunderstand the various vital
phenomena of the living organisms
as a systemic function, andpursue these systemic functions

innovative efforts in research and education that will produce a new set of values
for the future and dignity of life.
To meet the diverse expectations of society for advances in the life sciences,which are becoming increasingly sophisticated and complex, our school seeks
students from a broad spectrum of backgrounds who share these ideals of our

Nurture individuals who will be leaders in
the human society to pursue their activities
for the welfare and happiness of humans in
the 21st century, where humans will beliving in harmony with other living beings.

school, who possess basic academic skills and research aptitudes in the life
sciences, and who demonstrate a strong sense of ethics and responsibility intheir academic research. We especially welcome students who possess apioneering spirit to help propel the comprehensive and advanced branches of thelife sciences, free from preconceptions, while fully appreciating the dignity of life.

OPERATION POLICIES of our GRADUATE SCHOOL

Accordingly, the Graduate School of Biostudies endeavors to cultivate individuals
with the following attributes:
1. Researchers ready to discover, or to shed fresh light on, fundamental principles
of life, who will pioneer new areas of the life sciences;Training of individuals with the mostadvanced knowledge of the life
sciences for the next generation

1

The graduate student studies a higher level oflife sciences beyond the structures of past life
science - related fields at each undergraduatelevel to understand the integrated life sciences.
The goal is to nurture a new type of individualwith creative and innovative abilities to cope withthe various unknown themes to be confronted
by human beings in the next generation.

Training to establish self
for society

2

In the Graduate School of Biostudies,
individuals are trained to make a healthy
and fair judgment based on the academic
background of the staff and their prospects
for the future; and, establish a new system
to evaluate the effects of education frommultiple aspects from the past.

2. Researchers and engineers committed to global environmental conservationand gains in human health, welfare, and well-being, who are ready to makesocial contributions through roles in public and private research institutions;
3. Educators and working professionals with a broad-based understanding of thevaried phenomena of life in general, who are ready to make social
contributions through roles in education, industry, the news media, andgovernment;
4. Researchers, educators, engineers, and working professionals who possess
strong communication skills that enable them to hold discussions withresearchers and others from Japan and around the world in life
science–related fields.

3
503

Activation and flexibility ofstaff in the human relations
Research is pursued by each staff member
independently to develop a new life
science based on active exchange among
the various laboratories in the graduate
school.

4common language of “cells, molecules, and genes” that together form thefundamental principles of life, we have developed an integrated understanding ofdiverse life forms and the environments they help shape, and have launchedinnovative efforts in research and education that will produce a new set of values
for the future and dignity of life.
To meet the diverse expectations of society for advances in the life sciences,which are becoming increasingly sophisticated and complex, our school seeks
students from a broad spectrum of
backgrounds who share these ideals of our school, who possess broad academic
knowledge and advanced expertise gained through their master’ s education, whopossess strong research ability,
and who demonstrate an even stronger sense of ethics and responsibility in theiracademic research. We especially welcome students who possess a pioneering
spirit to help propel thecomprehensive and advanced branches of the life sciences, free frompreconceptions, while fully appreciating the dignity of life. Accordingly, theGraduate School of Biostudies endeavors tocultivate individuals with the following attributes:
1. Researchers ready to discover, or shed fresh light on, fundamental principles oflife, who will produce world-class research results in new areas of the life
sciences;
2. Researchers and advanced engineers committed to global environmental
conservation and gains in human health, welfare, and well-being, who are
ready to assume a leading role in public and private research institutions;
3. Educational leaders and high-level working professionals with a broad-based
understanding of the varied phenomena of life, who are ready to assume aleading role in education, industry, the news media, and government;

Use of current post-doctoral systemand evaluation of academic activities

The entrance exam will comprise achievement tests that include an assessmentof the applicant’ s ability to think logically in English, a skill that is required to read

4. Researchers, educational leaders, advanced engineers, and high-level working

Full use should be made of the current system, toprovide the increasing necessary number of
instructors per student, for the intensive training
to become life scientists at an international level,
for true development of a new research field.

and analyze an article published in an international journal; an assessment of theprofessionals equipped with strong logical explanation and communication

applicant’ s general knowledge of molecular biology, cell biology, biochemistry,skills, who can convey their ideas broadly to others in Japan and around theand other life science fields; an assessment of the applicant’ s fundamental

world and assume a leading role in a variety of fields.

Promotion of gender equality
To promote gender equality, we draw up the action plan.
Also we enhance the research environment and support for child-rearing and caregiving.

Graduate School of BIOSTUDIES, Kyoto University

U n i v e r s i t yknowledge as required to pursue his or her intended field of study; an

The entrance exam will comprise achievement tests that include an assessment

assessment of the applicant’ s judgement, thinking ability, communication skills,of the applicant’ s ability to think logically in English, which is required for

initiative, and ethical perspective. Admissions decisions will be made based oninternational communication; a presentation of the applicant’ s research findings

the applicant’ s overall performance on these exams.

during their master’ s program or elsewhere; and an oral exam to assess theapplicant’ s judgement, thinking ability, communication skills, initiative, andethical perspective. Admissions decisions will be made based on the applicant’ soverall performance on these exams.

Graduate School of BIOSTUDIES, Kyoto University04

G r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,Curriculum Policies of the Graduate School of Biostudies

K y o t o

Diploma Policy of the Graduate School of Biostudies

Master’ s Program

Doctoral Program

Master’ s Program

Doctoral Program

The Master’ s Program offers courses that appropriately combine lectures,

The Doctoral Program is comprised of lab-based research guidance and lectures

As an advanced discipline that holds the key to the future of humankind, the life

As an advanced discipline that holds the key to the future of humankind, the life

advanced studies, practical training, lab experiments, and seminars on

designed to cultivate greater breadth of scholarly knowledge and advanced

sciences are currently undergoing a major evolutionary change. The Graduate

sciences are currently undergoing a major evolutionary change. The Graduate

specialized subjects in order to achieve the objectives set forth in the Diploma

expertise in order to achieve the objectives set forth in the Diploma Policy.

School of Biostudies seeks to respond to this global change by building a

School of Biostudies seeks to respond to this global change by building a

Policy. Courses conducted in English are also offered for international students.

Courses conducted in English are also offered for international students. The

world-class center for research and by training human resources to lead the life

world-class center for research and training human resources to lead the life

The curriculum is specifically designed in accordance with the following

curriculum is specifically designed in accordance with the following principles.

sciences field into the next generation. Our school has engineered a true fusion

sciences field into the next generation. Our school has engineered a true fusion

1. The curriculum is organized and delivered to further develop broad scholarlyof cutting-edge areas in several existing fields and harnessed the commonof cutting-edge areas in several existing fields and harnessed the common

knowledge and advanced, specialized knowledge cultivated throughlanguages of cellular and molecular biology and genetics that together articulate

languages of cellular and molecular biology and genetics that together articulate

education in the Master’ s Program, and to enable students to acquire thethe fundamental principles of life. Furthermore, it has developed an integrated

the fundamental principles of life. Furthermore, it has developed an integrated

basic capabilities required of an independent researcher who can perform

understanding of diverse life forms and the environments they help shape,

understanding of diverse life forms and the environments they help shape,

foundation of competence for occupations that demand advanced expertise,well in an international setting. Moreover, research guidance is provided

adding the perspective of mathematical science, and has launched innovative

adding the perspective of mathematical science, and has launched innovative

based on the basic academic capabilities and specializations developed

through special seminars and special workshops in individual research labs

efforts in research and education that will define a new set of values for theefforts in research and education that will define a new set of values for thethrough education in the undergraduate program, as well as to enable theto cultivate advanced competence in research planning and implementation,

future and dignity of life.

future and dignity of life.

pursuit of cross-disciplinary study unencumbered by existing fields ofa capacity to explain research findings theoretically, communication skills,

To meet the diverse expectations of society for advances in the life sciences,

To meet the diverse expectations of society for advances in the life sciences,

specialization, which allows students to apply broad visions to put their own

and firm ethical integrity and a strong sense of responsibility in academic

which are becoming increasingly sophisticated and complex, the Graduate

which are becoming increasingly sophisticated and complex, the Graduate

research into perspective and build systems of knowledge. Moreover, theresearch. Learning outcomes in each course are evaluated through written

School of Biostudies confers the degree of Master of Life sciences on students

School of Biostudies confers the degree of Doctor of Philosophy in Life sciences

curriculum includes practical training, lab experiments, workshops, andexaminations, report examinations, and the outcomes of workshops, lab

who maintain enrollment for the requisite period, complete curricular courses,

on students who maintain enrollment for the requisite period, complete curricularexperiments, and practical training.

earn the prescribed number or more of credits in accordance with the Curriculum

courses, earn the prescribed number or more of credits in accordance with the

Policy, and pass a review and examination of a master’ s thesis prepared after

Curriculum Policy, and pass a review and examination of a doctoral dissertation
prepared after undergoing the required research guidance. A further prerequisite

principles.
1. The curriculum is organized and delivered to cultivate broad scholarly
knowledge spanning all domains of the life sciences, research capability instudents’ field of specialization, and specialized knowledge that will provide atutorials held in individual research labs that are designed to cultivatecompetence in research implementation, a capacity to explain research

2. Special emphasis is placed on students’ proactive pursuit of a research topic
that contributes to an academic or practical area of the life sciences,

undergoing the required research guidance. A further prerequisite for degree

sense of responsibility in academic research. Learning outcomes in each

mediated by research guidance and practical education, and leads to aconferment is the attainment of the following:

for degree conferment is the attainment of the following:course are evaluated through written examinations, report examinations, anddoctoral dissertation that contributes to the generation of new knowledge.

1. Broader-based scholarly knowledge; research capability in their field of

1. Broad-based scholarly knowledge and advanced, specialized knowledge tothe outcomes of workshops, lab experiments, and practical training.

This dissertation is assessed by a panel of three examiners and one or more

findings theoretically, communication skills, and firm ethical integrity and a

2. Emphasis is placed on students’ proactive pursuit of a research theme thatexpert examiner in accordance with the Diploma Policy.

contributes academically or practically to the life sciences, mediated by

The curriculum created on the basis of the above policies is presented inresearch guidance and practical education, and leads to a master’ s thesis

curriculum maps, and the details of each individual course are clearly stated inwith theoretical value. This thesis is assessed by a panel of three examiners

the syllabus.

in accordance with the Diploma Policy.
The curriculum created on the basis of the above policies is presented incurriculum maps, and the details of each individual course are clearly stated in

specialization; and advanced, specialized knowledge required for occupations
that demand advanced expertise
2. Firm ethical integrity and a sense of responsibility in academic research in thelife sciences field
3. Appropriate capabilities in research implementation in order to set topics and●Experimental Course and Seminar(20 credits : compulsory)●Advanced Experiments(8 credits : compulsory)●Common Compulsory Subject (1 credit)●Common Compulsory Subject (1 credit)●Common Elective Subjects (at least 9 credits)●Common Elective Subjects (at least 1 credit)

For graduation, the student must have enrolled

For graduation, the student must have enrolled forfor at least two years and have completed at

at least three years and have completed at least 10

least 30 credits. It is also required to pass thecredits. It is also required to pass the probation andprobation and an examination upon completionthe examination (thesis defense) upon completionof the Master’ s thesis written under theof a Doctoral thesis written under the supervision ofsupervision of faculty.

faculty.

Graduate School of BIOSTUDIES, Kyoto University

in the life sciences field
3. Advanced capabilities in research planning and execution in order to set
unique topics and themes based on scholarly knowledge, techniques, andskills in the life sciences field, and to achieve solutions and development

and fields related thereto, and to deepen mutual understanding

Requirements forcompleting the Doctoral program

occupations
2. Firm ethical integrity and a strong sense of responsibility in academic researchsciences field, and to achieve solutions and development thereof

promote one’ s research findings to researchers in one’ s own specialization

Requirement forcompleting the Master’ s program

engage as independent researchers or lead careers in advanced professional

themes based on scholarly knowledge, techniques, and skills in the life

4. Appropriate skills in theoretical explanation and communication required tothe syllabus.

05

U n i v e r s i t y

5. A master’ s thesis, presented with theoretical rigor and clarity, with appropriate
setting of research goals, planning, and execution of experimental work
related thereto and discussion in regard to the findings thereof

thereof through planning and implementation of joint research with otherresearch institutions as necessary
4. Advanced skills in theoretical explanation and communication required topromote one’ s research findings to researchers in one’ s own specializationand fields related thereto, and to deepen mutual understanding
5. Doctoral dissertation that includes research findings demonstrating new
discoveries or concepts that contribute academically or practically to the life
sciences
Candidates considered to have made outstanding progress in their studies andresearch may be eligible for completion of the doctoral program in a reduced
period of enrollment.

Graduate School of BIOSTUDIES, Kyoto University

06

G r a d u a t e

S c h o o l

o f

B I O

S T U D I E S ,K y o t o

U n i v e r s i t y

Composition of Departments

Research Laboratories in the Graduate School of Biostudies
Division of Integrated Life Science

Division of Systemic Life Science

In this division, education and research are focused on the elucidation of basic mechanisms regulating the chromosome transmission,

In this division, education and research are focused on the elucidation of the fundamentals of molecular andsystemic biology, cell biology and immunology. Experimental approaches are taken with viruses, microorganisms,
cultured cells and animals. We pursue education and research to elucidate the molecular aspects of Systemic Life
Science.

chromosome replication, RNA architecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development,
developmental plasticity, bioconversion, and environmental adaptation. Experimental approaches are taken with microorganisms,
plants, and animals. We pursue education and research to elucidate the molecular aspects of Integrative Life Science.

Dept. of Gene Mechanisms

Chromosome Transmission/Gene Biodynamics/Cell Cycle Regulation

9

Major interest is the molecular mechanism of higher order phenomena (cell proliferation, morphogenesis,
canceration, aging, etc.) and the cellular function (cell cycle, chromosome replication, segregation, maintenanceand repair, etc.) in unicellular and multicellular organisms.

Dept. of Cell and Developmental Biology

Cell Recognition and Pattern Formation/Signal Transduction

Plant Molecular Biology/Molecular and Cellular Biology of Totipotency

11

13

The department pursues the basic research and application of molecular and cellular principles related to plant
growth and development. We take approaches by cell biology, chemical biology, molecular and cellular biology,
molecular genetics, and genomics.

Dept. of Applied Molecular Biology

Biosignals and Response/Applied Molecular Microbiology/
Molecular Biology of Bioresponse

15

Developmental Neurobiology/Biochemical Cell Dynamics/
Multidisciplinary Biology

18

21

Ultrastructural Virology/Aging and Infection Control

23

We are studying aging, host responses to viral infections, and immune regulation at the molecular, cellular, andindividual levels using molecular/genetic/cell biological and morphological/structural approaches.

Dept. of Human-Residential Bifidobacteria (HRB) Research (Industry-Academia Collaboration Course) Symbiotic and Coevolutionary Mechanisms

24

Attached
Research Centers

The mission of this department is to elucidate the mechanisms underlying symbiosis between
bifidobacteria and their human host, and to understand the molecular basis of the health-promoting effects ofprobiotic Bifidobacterium strains.

07

Radiation Biology Center

Radiation System Biology/Mutagenesis/Late Effects Studies/
Genome Repair Dynamics/Chromosome Function and Inheritance

Strategic Education Program/Computational and Systems Biology/
Computational Genomics/Advanced Big Data Analysis

Our center consolidates and systematizes informatics-based educational and research resources in life sciencethroughout Kyoto University, and develops new programs in order to generate expert "two-way" researchers who leaddata-driven life science.

Graduate School of BIOSTUDIES, Kyoto University

26

29

Cancer, autoimmune diseases, and life-style related diseases can be caused by genetic abnormalities andaberrant response mechanisms. We aim to reveal dysfunctional biological mechanisms of cell proliferation,
cancer, and immunological, genetic diseases.
Functional Biology

31

Cell–cell adhesion is essential for the establishment of multicellular organisms. We purse the systemic
regulation mechanisms of cell–cell adhesion and signal transduction. We aim to elucidate the mechanisms oftissue formation and the pathogenesis of various diseases caused by disruption of cell–cell adhesion. We also
aim to establish the basis for drug discovery and development, and to establish new therapeutic strategies.
Science Communication/Chromosome Function and Inheritance32

The Department of Biology Education and Heredity is composed of the Laboratory of Science Communication,and the Laboratory of Chromosome Function and Inheritance. The Laboratory of Chromosome Function andInheritance studies the mechanisms of meiosis using cell biological and genetic approaches. The department
as a whole focuses on training internationally-minded scientists, developing English-based science educationand communication at the highest levels.

Dept. of Systems Biology

Brain Development and Regeneration

33

We aim to understand living systems from cellular to animal individual levels focusing on developmental andregulatory mechanisms with cutting-edge research tools, such as molecular genetics, molecular visualization
sensors, optogenetics, live imaging and mathematical modeling.

Dept. of Genome Biology

Genome Maintenance/Genome Stress Response/
Cancer Cell Biology/Chromatin Regulatory Network

34

Genome and epigenome information are maintained by an intricate molecular system acting against exogenousand endogenous perturbations. We aim to study defects in these mechanisms that result in human disorders.
41

Our center is trying to elucidate basic mechanisms behind biological responses to irradiation as well as chromosomal damages, andthereby pursue fundamental basis for evaluation of radiation exposure risks and for development of innovative cancer radiation
therapy. To achieve the goals, our center promotes collaborations in the intranational and international research communities.

Center for Living Systems Information Science(CeLiSIS)

Immunobiology/Molecular Cell Biology and Development

Molecular Neurobiology/Genetics

Dept. of Biology Education and Heredity

The development, function, and maintenance of tissues and organs are regulated by a coordinated interplay ofcell-intrinsic programs and intercellular signals. We seek their mechanisms at cellular, organellar and molecularmechanisms using various model systems, including the brain and immune systems.

Dept. of Molecular and Cellular Biology

25

The objectives of our studies are to clarify the mechanisms that regulate hierarchical structures composing
cells, tissues, organs, at the molecular, cellular, and individual levels, especially about cell growth,differentiation, cell death, cell-cell interactions, and histogenesis.

Dept. of Functional Biology

We aim at understanding fundamental systems underlying environmental responses by organisms throughstructural-functional study of information molecules involved in environmental responses, study of regulatory mechanismsof development in response to environmental signals, and ecosystem-level study of multi-species (multi-genome) systems.

Dept. of Molecular and Developmental Biology

Dept. of Animal Development and Physiology

Dept. of Signal Transductions

Signal response mechanisms have evolved in organisms through adaptations to fluctuations or changes in thenatural environment. These mechanisms are being elucidated using various model organisms at different levels(individual, organ, tissue, cell, molecule and gene), and directing this knowledge toward applications with
benefits to human welfare is a priority.
Developmental Biology/Ecosystems and Coevolution/
Dept. of Responses to Environmental Signals and Stresses Plant
Plasma Membrane and Nuclear Signaling

Single-Molecule Cell Biology

We will challenge direct viewing of biomolecular dynamics using single-molecule imaging and multi-target
super-resolution microscopy IRIS. By elucidating the molecular basis of morphogenesis and the action ofdrugs, we will pursue principles in biology and seeds for drug development.

We are studying signal transduction mechanisms that control organogenesis and animal growth in response to nutrition andgrowth factors. We are also dissecting operating principles of neuronal circuits that evoke behaviors to sensory stimuli.

Dept. of Plant Gene and Totipotency

Dept. of Molecular and System Biology

Dept. of Mammalian Regulatory Network

RNA Viruses/Cell Division and Differentiation/
Cellular and Molecular Biomechanics/Mechanosensory Physiology

38

Laboratories consisting of this Department study multi-dimensional networks of life signals that contribute to
the integrity of higher organisms. Studies also include those utilizing viruses, animal models, and biomaterials,
serving to establish basic principles in life science.
43

Dept. of Advanced Imaging (Industry-Academia Collaboration Course)

Spatiotemporal Optical Control

40

We will understand the principle of biological functions by measuring and manipulating dynamics of genes andmolecules multidimensionally with cutting-edge imaging, optical control technologies, and optical probes.

Graduate School of BIOSTUDIES, Kyoto University

08

Division of Integrated Life Science ｜ Department of Gene Mechanisms

Laboratory of
Chromosome
Transmission

Division of Integrated Life Science ｜ Department of Gene Mechanisms

Laboratory of
Cell Cycle Regulation

Assoc. Prof.

NAKASEKO, Yukinobu

Main theme
We are focusing on analyzing the genes
involved in regulation of chromosome
function. Especially, the genes essential for
mitosis have been studied. Fission yeast
Schizosaccharomyces pombe is used as amodel system. This yeast has all basic
features essential for eukaryotic cell division.
Many genes have been identified which
regulate the cell cycle of this yeast. Also, theirfunctions as well as their primary structure
have been shown to be conserved among all
eukaryotic cells. We are trying to characterizethese genes and their functions by genetical
approach.

Professor

AOKI, Kazuhiro
Main theme
A cell is a vessel stuffed with proteins,
nucleic acids, lipids, and small
compounds. Within the cell, an immense
number of physicochemical reactions areconstantly taking place. Cells maintainhomeostasis at various levels, from thecellular to the organismic, by perceiving
external substances, processing thisinformation within intricate intracellular
networks, and manifesting adaptive
phenotypes. Our research focuses on
elucidating the mechanisms underlying
the cellular information processing(encoding) and cell fate decision making(decoding). In addition to thedevelopment of quantitative
measurement and perturbation
techniques, we aspire to address the

Elucidation of whole functional network ofthese genes is one of a goal in our research.

Laboratory ofGene
Biodynamics

Assoc. Prof.

SHIRAISHI, Hideaki

Main theme
We are interested in the mechanism of growth,development and evolution of photosynthetic
microorganisms and currently focusing on the
study of the edible cyanobacterium Arthrospira(Spirulina) platensis. A. platensis is afilamentous alkalophilic cyanobacterium thathas been traditionally consumed as food bypeople living along the shores of alkaline lakes
in several regions in the world. Because it canbe cultured under alkaline conditions where
growth of other microalgae is suppressed, it
can be produced in mass cultures outdoors as
an almost single algal strain. Because of its
easiness of mass culture, it is commercially
produced in many subtropical areas in the

Lab URL

09

Graduate School of BIOSTUDIES, Kyoto University

http://kuchem.kyoto-u.ac.jp/seika/

fundamental question of “what is life?”
through approaches such asreconstructing a cell on a computer.

Specially Assigned Professor

HONDA, Naoki

Research subjects

・Visualization and manipulation ofmolecules involved in cell cycle
progression
・Understanding and manipulation of
biological functions that emerge in cell
populations
・Elucidation of intracellular mechanicalproperties and their physiologicalsignificance・Implementation of whole cell modeling・Development and application of novel
biosensors and optogenetic tools

world and consumed worldwide as food, foodadditives, and feed for animals and fishes. We
are currently focusing on developing tools formolecular genetic studies of thiscyanobacterium.

Filamentous cyanobacterium Arthrospira platensis
and the aggregated expolysaccharides produced bythem

https://sites.google.com/kyoto-u.ac.jp/cellcycle/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

10Division of Integrated Life Science ｜ Department of Cell and Developmental Biology

Division of Integrated Life Science ｜ Department of Cell and Developmental Biology

Laboratory of
Cell Recognition and
Pattern Formation

Senior Lecturer

KUSAKABE, Morioh

Main theme
Professor

UEMURA, Tadashi
Senior Lecturer

USUI, Tadao

Main theme
We are interested in:
1. Contributions of nutrients andassociated microbes to animal growth
and aging

2. Neuronal circuits that evoke selective
behaviors in response to sensory
stimuli
3. Reproductive manipulation ( “malekilling” ) caused by insect symbionts

We are interested in identifying and elucidating
molecular mechanisms that regulate cellproliferation, cell differentiation anddevelopmental processes. The current topics
include 1) regulatory mechanisms andfunctions of the MAP kinase cascade
pathways, 2) identification of novel signaltransduction mechanisms, 3) roles of protein
kinases in cell regulation, 4) signalingmechanisms in developmental processes.

Laboratory of
SignalTransduction

Assist. Prof.

MIYATA, Yoshihiko

Microinjection into Xenopus laevis
embryos at the cleavage stage

Multiciliated cell differentiation in asalt-and-pepper pattern

Assist. Prof.

HATTORI, Yukako

http://www.signal.lif.kyoto-u.ac.jp/

Lab URLThis study was published in Life Science Alliance on October 6, 2023.
Down syndrome, the most prevalent genetic disorder atbirth and a primary cause of intellectual disability, resultsfrom the presence of an extra copy of chromosome 21
in humans. Triplication of the DYRK1A gene on
chromosome 21 is responsible for many pathologicalphenotypes observed in individuals with Down
syndrome. DYRK1A, encoding the protein kinase, is also
implicated in numerous neurodevelopmental disorders,
including autism spectrum disorder. Hence, theregulation of DYRK1A function is of both physiologicaland clinical significance. In this study, we identified
FAM53C, which previously lacked known biological
function, as a binding partner of DYRK1A. The binding of
FAM53C suppressed the protein kinase activity of
DYRK1A. DYRK1A contains a nuclear localization signal,causing its accumulation in the nucleus upon celloverexpression. Co-expression of FAM53C induced there-localization of DYRK1A to the cytoplasm, uncovering
FAM53C’ s role in anchoring DYRK1A within thecytoplasm. These results demonstrate that FAM53C

binds to DYRK1A, suppresses its kinase activity, andretains it in the cytoplasm. For the first time, theseresults provide an explanation for the distribution ofendogenous DYRK1A in the cytoplasm of normal brain
tissue. The FAM53C-mediated regulation of DYRK1A’ skinase activity and cellular localization may have asubstantial impact on gene expression caused bynormal and aberrant levels of DYRK1A. This provides
valuable biological and potential clinical implications.

TOPICS

Identification of FAM53C as a cytosolic-anchoring inhibitory binding protein of
the kinase DYRK1A

FAM53C regulates the protein kinase activity
and the cellular distribution of DYRK1AFor further information, please refer to the URL below.

Lab URL

11

Graduate School of BIOSTUDIES, Kyoto University

http://www.cellpattern.lif.kyoto-u.ac.jp/

https://www.kyoto-u.ac.jp/en/research-news/2023-12-20-0
https://www.life-science-alliance.org/content/6/12/e202302129
DOI: https://doi.org/10.26508/lsa.202302129

Graduate School of BIOSTUDIES, Kyoto University

12Division of Integrated Life Science ｜ Department of Plant Gene and Totipotency

Division of Integrated Life Science ｜ Department of Plant Gene and Totipotency

Laboratory of
Molecular and Cellular
Biology ofTotipotency

Laboratory of
Plant Molecular
Biology

Professor

Professor

KOHCHl, Takayuki
Assoc. Prof.

YASUI, Yukiko

Assist. Prof.

NAKANO, Takeshi
Main theme
Research in this laboratory focuses on
the adaptive regulation of growth anddevelopment to environmental conditions
and its evolution by using model
photosynthetic organisms. Especiallywith the liverwort Marchantia
polymorpha, which is a basal land plant
ideal for comparative evolutionary

studies and amenable to molecular
genetic manipulation, we aim to elucidate
principles and ancestral molecularmechanisms of photomorphogenesis,
growth phase transition, phytohormone
signaling, meristem function, sex
determination,and sex differentiation in land plants.

YOSHITAKE, Yoshihiro

Graduate School of BIOSTUDIES, Kyoto University

Major research topics are:Plant growth has been administrated bycooperative regulations between plant
cell differentiation/division/elongationand photosynthesis. Based on thesescientific aspects, our laboratory is trying
to reveal the plant growth mechanismsby ‘chemical biology’ and ‘molecular andcellular biology’ .

(1) Growth regulation by plant hormone
signaling

Assoc. Prof.

http://www.plantmb.lif.kyoto-u.ac.jp//

MIYAKAWA,Takuya(2) Chloroplast regulation byprassinosteroid(3) Chemical functions to regulate plant
growth and differentiation(4) Plant biomass production regulated
by chemicals and genes(5) Protein functions to regulate plant
growth mechanism by structure
biologyLab URL

13

Main theme

https://plantchembio.lif.kyoto-u.ac.jp/

Assist. Prof.

YAMAGAMI, Ayumi

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

14

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Laboratory of
Biosignals andResponse

Assoc. Prof.

YAMANO, Takashi

Main theme
Professor

NAGAO, Masaya
Assoc. Prof.

KAMBE, Taiho

Main theme
Bio-prospecting, a research strategy
searching for compounds that possess
beneficial activity for health from natural
sources, is one of the projects in thislaboratory. Especially, compounds thatare useful for treatment oflifestyle-related diseases and cancer are
the main targets of our bio-prospecting.

We are also studying how organisms
perceive environmental signals andtransduce these signals into changes ingene expression, focusing mainly on themolecular and cellular basis of zincmetabolism (such as uptake, storage,
delivery, and maintenance of metal
concentration in cells) in mammal.

Using the model green alga
Chlamydomonas reinhardtii, also known as"green yeast," we will elucidate survival
strategies of microalgae in response tovarious environmental stresses at the
genomic and molecular levels and expand
our research into applications such as
modification of photosynthesis, CO2
reduction, bioenergy, and valuable
material production.

Laboratory ofApplied
Molecular
Microbiology

・protein localization changes in response
to environmental stimuli and their
physiological significanceCurrent projects
Molecular mechanisms of・photosynthetic regulatory network bysensing environmental signals
・photosynthetic CO2-concentrating
mechanism
・formation, disappearance, andinheritance of phase-separatedorganelles

・signal transduction, energy storage, andinduction of sexual reproduction during
nutrient starvation
http://www.molecule.lif.kyoto-u.ac.jp/

Lab URL

Stimulation of lipid accumulation by plant extracts

This study was published in Nature Chemical Biology on Mar 2, 2023.
Mucin, the main glycoprotein constituting mucus
layers which cover the epithelia of the gastrointestinal
tract, not only plays a role in preventing pathogens
from invading but also provides carbon sources to gut
microbes, thereby being considered to support a
symbiotic relationship between gut microbiota andthe host. However, it remains to be elucidated how
the microbes utilize mucin glycans. A research groupled by Assoc. Prof. Toshihiko Katoh and Prof. Takane
Katayama (Lab. of Molecular Biology andBioresponse) discovered that a sulfoglycosidase(BbhII) from a human commensal, Bifidobacteriumbifidum, specifically acts on sulfated mucin glycans.
Administration of a bbhII mutant of B. bifidum togerm-free mice resulted in the accumulation ofcertain structures of
sulfated glycans in fecal
mucins. In vitro and in
silico analyses of human
fecal samples indicate across-feeding of thedegradant sugar amonggut microbes. The
results provide a basis
for understanding themechanisms underlying
gut microbiota formation
An image of mucin degradationand ecosystem.

TOPICS

A gut microbial enzyme involved in sulfated mucin glycan degradation

by Bifidobacterium bifidum

For further information, please refer to the URL below.

Lab URL

15

Graduate School of BIOSTUDIES, Kyoto University

http://www.seitaijoho.lif.kyoto-u.ac.jp/

https://www.nature.com/articles/s41589-023-01272-y

Graduate School of BIOSTUDIES, Kyoto University

16

Division of Integrated Life Science ｜ Department of Applied Molecular Biology

Division of Integrated Life Science ｜ Department of Responses to Environmental Signals and Stresses

Laboratory of
Molecular Biology ofBioresponse

Laboratory of
Plant Developmental
Biology

Professor

Professor

KATAYAMA, Takane
Assoc. Prof.

KATOH, Toshihiko

ARAKI, Takashi
Main theme
We are conducting research focusing on
the symbiosis and co-evolution between
gut microbes and the host. In particular,
we are trying to understand the molecularbasis of how gut microbes proliferate
and persist in the host gut by
assimilating milk oligosaccharides andmucin O-glycans produced by the host.

Lab URL

17

Graduate School of BIOSTUDIES, Kyoto University

・Symbiosis between bifidobacteria andinfants mediated through breastmilk
・Carbohydrate assimilation mechanism
in gut microbes
・Aromatic amino acid metabolism in gut
microbes
・Development of an apical aerobic
co-cultivation device

http://www.bunshioutou.lif.kyoto-u.ac.jp/

Main theme
We are interested in molecularmechanisms underlying plant's responses
to environment. Plants have evolved
plastic developmental programs with both
genetic and epigenetic basis to adapt their
sessile mode of life to changing
environment. Using an angiosperm,
Arabidopsis thaliana and a liverwort,
Marchantia polymorpha as model
systems, we have been investigating (1)regulation of growth phase transition(especially reproductive transition) in
response to environmental signals, (2)mechanism of day-length perception byphotoreceptors and circadian clock, (3)long-distance systemic signaling (e.g.
florigen) in the control of development, (4)sexual reproduction processes (especially,
germline specification andgametogenesis), and (5) origin andevolution of regulatory systems for plastic
development.

http://www.plantdevbio.lif.kyoto-u.ac.jp/

Assoc. Prof.

YAMAOKA, Shohei

Assist. Prof.

INOUE, Keisuke

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

18

Division of Integrated Life Science ｜ Department of Responses to Environmental Signals and Stresses

Division of Integrated Life Science ｜ Department of Responses to Environmental Signals and Stresses

Laboratory of
PlasmaAssoc. Prof.
Membrane and
YOSHIMURA, Shigehiro
Nuclear Signaling

Laboratory of
Ecosystems andCoevolution

Main theme
Professor

TOJU, Hirokazu
Assist. Prof.

FUJITA, Hiroaki

Main theme
Throughout its four-billion-year evolution,
life has expanded into diverse
environments. In the history of life,
symbiosis has brought about
innovations, resulting in explosive
evolution and species diversification in
new environments. We aim to understandhow interactions between species haveorganized ecosystems on the Earth.
Combining fieldwork in natural
ecosystems with genomics andinformation science, we will decipher thedriving principles of life systems at the
population, community, and ecosystemlevels from phenomena at the molecularand cellular levels.

Research subjects

・Roles of microbiomes in environmental
adaptations of plants

Our laboratory studies structural andfunctional dynamics of cellular proteins andorganelles from micro- and macro-scopic
viewpoints. We try to understand how the cell
cycle and intracellular signaling are regulated
and how their collapses cause diseases.

Research topics(1) How post-translation modification suchas phosphorylation regulates liquid-liquid
phase separation(2) How mitotic
phosphorylation/dephosphorylation cycle
regulates the cell cycle and cellproliferation

Assist. Prof.

KUMETA, Masahiro(3) How cell division is regulated during
tissue morphogenesis and development.
(4) How intracellular membrane-lessorganelles play roles in anti-viral functionof host factors

・Coevolutionary history of land plants
and mycorrhizal/endophytic symbionts
・Effects of aquatic/gut microbiomes onfish’ s physiology and ecology
・Coevolution of invertebrates and their
symbionts/parasites

http://www.chrom.lif.kyoto-u.ac.jp/

Lab URL

・Multistability and temporal dynamics of
ecosystems

This study was published in Current Biology on September 29, 2023.

Exploring the diversity of life

Exploring the principles of ecosystem-level phenomena

Lab URL

19

Graduate School of BIOSTUDIES, Kyoto University

Land plants produce germ cells in a haploid
multicellular body called gametophyte after meiosis.
In flowering plants, female and male gametophytes
are few-celled tissues in floral organs, called embryo
sac and pollen, respectively. In contrast, inbryophytes, gametophyte dominates the life cycle as
an independent free-living generation. Despite thisdiversity of reproduction, they have evolved from acommon ancestor diverged from charophyte algae
500 million years ago.
Associate Professor Shohei Yamaoka and hiscolleagues showed that two transcription factors,
BONOBO and LRL/DROP, are evolutionarily conserved
among land plants, and form a heterodimer toregulate germ cell differentiation in the gametophytesof both the flowering plant Arabidopsis thaliana andthe liverwort Marchantia polymorpha. The LRL/DROP
genes are also present in charophyte algae, however,the BONOBO genes are specific to land plants. Ourfindings suggest that land plants invented the
BONOBO–LRL/DROP heterodimer as a key togametogenesis at an early stage of evolution.

TOPICSAn evolutionarily conserved heterodimer regulates germ cell differentiation in land plants

The life cycle of land plants and the regulationof germ cell differentiation in the gametophyteby the BONOBO-LRL/DROP heterodimer

For further information, please refer to the URL below.

https://doi.org/10.1016/j.cub.2023.09.020

https://sites.google.com/view/tojulab

Graduate School of BIOSTUDIES, Kyoto University

20Division of Integrated Life Science ｜ Department of Molecular and Developmental Biology (Cooperation Course)

Laboratory ofDevelopmental
Neurobiology

Division of Integrated Life Science ｜ Department of Molecular and Developmental Biology (Cooperation Course)

Professor

Professor

KENGAKU, Mineko

SUZUKI, Jun

AFFILIATION：
Institute for Advanced Study

AFFILIATION：
Institute for Advanced Study

Main theme

Research topics

Main theme

going to uncover the mechanisms.

During brain development, neurons directionallymigrate from the birthplace to their destination
within the cortex, and then arborize
well-patterned dendrites and axons to contact
with their specific synaptic counterparts.
Failures in these processes lead toneurodevelopmental and neuropsychiatry
diseases. The major goal of our research is toclarity the mechanisms that govern theformation and maintenance of the mammalianbrain.

Live imaging and molecular analyses ofdynamics and kinetics of neuronal motilities(cell migration, process arborization, organelletransport, etc).

In principle, we identify specific genes regulating
the biological phenomenon with our interests.
The main approaches are as follows: Expression
cloning using cDNA library, functional screening
using sgRNA library in a CRISPR/Cas9 system,
biochemical approach in combination with mass
spectrometry. By establishing the robust
experimental systems, we try to reveal thesecrets of biological phenomenon. Currently, we
are interested in the biological phenomenon
called phospholipid scrambling that regulates
blood coagulation, engulfment of dead cells, cellfusion, cancer progression, stress response,
regulation of brain/bone/muscle functions andso on. In spite of its importance in various
biological systems, much is unknown about how
phospholipid scrambling is regulated. We are

Research topics

Elucidating the mechanism of external
stimuli-dependent neuronal differentiation andcircuit organization.
Developing live imaging techniques forreal-time observation of molecular and cellular
dynamics of brain development.

・Identification of novel scramblases onplasma membranes
・Identification of novel scramblases on
intracellular membranes
・Identification of regulators or subunits inscramblases
・Understanding physiological roles ofscramblases
・Understanding how diseases occur by
scramblase deficiency
・Understanding mechanisms of removal ofunwanted cells
・Developing in vivo screening systems

http://www.suzuki.icems.kyoto-u.ac.jp/en/

Lab URLLab URL

http://www.kengaku.icems.kyoto-u.ac.jp
Professor

TANIGUCHI, Yuichi

TOPICS

Laboratory ofBiochemical
Cell Dynamics

Laboratory ofMultidisciplinary
Biology

AFFILIATION：
Institute for Advanced Study

Evolution of plant hormone gibberellin key to liverwort survival
This study was published in The Plant Cell on August 1, 2023.
Plants experience competition from their neighbors. To
better survive the restricted light conditions, plants
adjust their shape and reproductive strategy with thehelp of the plant hormones. While grasses and flowers
resolve this problem with gibberellin, liverworts lack thecritical genes for making standard gibberellins. Prof.
Kohchi’ s group revealed that the liverwort Marchantia
polymorpha uses gibberellin precursors to produce a yetunidentified signaling molecule that helps M. polymorpha
readjust itself under shaded conditions. The
investigation on gibberellin precursor response inliverworts shed light on the underlying mechanism andevolution of gibberellin-related compounds modulating
their growth.

Main theme

Research topics

We aim to understand the working principle ofcomplex biological systems (e.g. the cell andgenome) constituted with a wide variety ofmolecules. Based on knowledge of multiple
academic fields including biology, physics,
chemistry, computer science, engineering andinformatics, we challenge development of new
innovative technologies and creation of new life
science fields.

・Elucidating the working principles of the
genome based on molecular or atomic
structures
・Understanding the constitutional principlesof single cells
・New principles and methods in diseasediagnosis and treatment

Biosynthesis of gibberellin-related compounds
modulates far-red light responses in the liverwort

For further information, please refer to the URL below.

https://www.kyoto-u.ac.jp/en/research-news/2023-10-04-0
https://doi.org/10.1093/plcell/koad216

21

Graduate School of BIOSTUDIES, Kyoto University

Nucleosome-resolved 3D
genome structure

Single molecule fluorescence microscope

https://taniguchi.icems.kyoto-u.ac.jp/en

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

22Division of Integrated Life Science ｜ Department of Molecular and Cellular Biology (Cooperation Course)

Laboratory of
Ultrastructural
Virology

Division of Integrated Life Science ｜ Department of Human-Residential Bifidobacteria (HRB) Research (Industry-Academia Collaboration Course)

Laboratory ofSymbiotic andCoevolutionary
Mechanisms

Professor

NODA, Takeshi
AFFILIATION：
Institute for Life and Medical Sciences

Assoc. Prof.

SUGITA, Yukihiko

Assist. Prof.

NAKANO, Masahiro

Assist. Prof.

MURAMOTO, Yukiko

Our laboratory aims to elucidate thereplication mechanisms of human pathogenic
viruses, such as influenza virus, Ebola virus,
and SARS-CoV-2, for the prevention andtreatment of viral infectious diseases. To thisend, we use several cutting-edge techniquessuch as cryo-electron microscopy, electron
tomography, and high-speed atomic force
microscopy to visualize virus entry, replication,assembly, and virus formation. In addition, we
use human respiratory organoids tounderstand virus replication and the host
responses in human respiratory organs. We
also develop novel therapeutics for deadly
viruses such as Ebola virus.

Lab URL

https://www.facebook.com/NodaLab/

Professor

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

SAKANAKA, Mikiyasu

Visiting Professor

ODAMAKI, Toshitaka

This study was published in Nature Communications on Jan 8, 2024.

AFFILIATION：
Institute for Life and Medical Sciences

We are studying the mechanisms of aging andinfection, and how to control them via food andmicrobiota. The microbiota that are endemic in thegut and skin are deeply involved in aging andinfection of the host. We have elucidated themechanisms of the interaction between the
microbiota and the host using C. elegans and miceas model organisms. The gut microbiota is also
attractive as a tool to potentially control
inflammation. In recent years, inflammatory bowel
disease has been on the rise, and we have foundthat some strains of Escherichia coli, which areoften highlighted for their diarrheagenic properties,
show inhibitory activity in the induction of
inflammatory cytokines. We are also focusing on
mitochondria, which are closely related to aging.
We are challenging the development of methods forimaging mitochondrial activity and developing
methods to extend lifespan by targeting
mitochondria.

The department of Human-Residential
Bifidobacteria (HRB) Research was established in
October 2020 as an industry-academia research
Research topics
collaboration between Morinaga Milk Co. Ltd., and
the Graduate School of Biostudies, Kyoto
・Elucidation of the symbiotic and co-evolutionary
University.
mechanisms between biﬁdobacteria, gut bacteria,
Probiotics are defined as "live microorganisms
and humans.
that, when administered in adequate amounts,
・Understanding the molecular basis ofconfer a health benefit on the host," andhealth-promoting eﬀects of probiotics andbifidobacteria and lactobacilli are most commonly
development of technologies for social
used as probiotics in food and medicine globally.
implementation.
However, the mechanisms behind the probiotic
effect of bifidobacteria remain
unclear, because probiotics research
has historically focused on the human(host) side (e.g., functional evaluation
through clinical trials) and researchfrom the bacterial side is limited. To
address this research gap, ourdepartment will promote researchDistinctive differences in ecological distribution of bifidobacteria(HRB vs non-HRB).
from the probiotic side. Specifically,

Program-Specific
Assoc. Prof.

BPG4 regulates chloroplast development and homeostasis via brassinosteroid signaling.

KAGE-NAKADAI, Eriko

Main theme

23

Scanning electron micrograph of Ebola
viruses budding from cell surface.

we will understand the molecular basis of thehealth-promoting effects of probiotic HRB strains,and elucidate the molecular mechanisms
underlying symbiosis between HRB and humans.

Research subjects

・Methods to control aging and elucidation of its
mechanisms

・Imaging technology focusing on mitochondria andmetabolism
・Anti-infective effects and improvement of hostresistance against bacterial infection

・Host inflammation suppression by gut microbiota
・Interaction between host and microbiota

Brassinosteroids (BRs), plant steroid hormones, havecrucial effects on not only plant growth but also
chloroplast development. As chloroplastdevelopment adapts to the environment for
performing suitable photosynthesis, the regulatory
mechanism of chloroplast development by the aspectof chemical biology should be important. However,the detailed molecular mechanisms of BR signaling inchloroplast development remain unclear. Here, theresearch group with Takeshi Nakano, Takuya
Miyakawa, Ayumi Yamagami, and Ryo Tachibana et
al. identify BPG4 as a novel regulator of chloroplastdevelopment that is involved in light and BR signaling.
The decrease of BPG4 expression in the
BPG4-knockout plant showed the acceleration of theamounts of chlorophylls and the chloroplastdevelopment that is linked by the thylakoid membranestacking number per grana. Our findings suggest that

BPG4 acts as a chloroplast homeostasis factor by
optimizing chloroplast development which would be
useful in developing novel crops and vegetables to besuitable in variable environmental conditions on theearth.

TOPICS

Laboratory ofAging andInfection Control

Department Overview and Research
Theme

Main theme

BPG4 regulates the greening of leaves and chloroplast developments

For further information, please refer to the URL below.

https://doi.org/10.1038/s41467-023-44492-5

https://www.infront.kyoto-u.ac.jp/laboratory/lab48/
Graduate School of BIOSTUDIES, Kyoto University

24Division of Systemic Life Science ｜ Department of Molecular and System Biology

Division of Systemic Life Science ｜ Department of Animal Development and Physiology

Laboratory ofSingle-Molecule
Cell Biology

Assoc. Prof.

TAKAHARA, Kazuhiko

Main theme
Professor

WATANABE, Naoki
Assoc. Prof.

YAMASHIRO, Sawako

Assist. Prof.

MIYAMOTO, Akitoshi

Main theme
Our laboratory aims at bridging the gap
between molecular activities and cell
physiology by visualizing signaltransduction and cell structure
remodeling processes with live-cell
fluorescence single-molecule(eSiMS) microscopy. We also invented
new super-resolution microscopy called
IRIS, which achieves unprecedented
ultra-high density (= high-fidelity) labelingof multiple targets in a single specimen.
Furthermore, real-time imaging revealed

an unexpected allosteric effect ofanti-cancer kinase inhibitors, which may
potentially convert inactive oncogenic
kinases into an activated state. By
real-time and high-resolution monitoringof cell structure and adhesion molecules
using these advanced optical techniques,
our laboratory unveils mechanisms anddynamics of pathophysiological cellsignaling, drug actions and bodystructure remodeling.

Our interest is the induction and control of
immunity. We focus on dendritic cells (DC),which are a primary antigen-presenting cell in the
immune system. We are especially interested infunctions of lectin molecules expressed on DC
and its relative, macrophage, that recognize
polysaccharides on pathogenic agents. The
study includes analyses of interaction between

Laboratory of
Immunobiology

polysaccharides and lectins, and subsequentcellular and systemic responses in co-operation
with TLR signaling. In this study, we found thatcertain lectin-polysaccharide interaction induced
immune suppressive environment, amelioratingexcessive and lethal inflammation. By thesestudies, we would like to develop new methods
to control immune system.

Mouse lectins expressed on DCs/macrophages

http://zoo.zool.kyoto-u.ac.jp/imm/

Lab URL

The findings were published in Nature Communications on December 20, 2023.
Force transmission at integrin-based adhesions isimportant for cell migration and mechanosensing.
Talin is an essential focal adhesion (FA) protein thatlinks actin filaments (F-actin) to integrins. F-actin
constantly moves on FAs, yet how Talinsimultaneously maintains the connection to F-actin
and transmit forces to integrins remains unclear. A
research group led by Senior Lecturer Sawako
Yamashiro and Professor Naoki Watanabe of Kyoto
University Graduate School of Biostudies, incollaboration with Professor Dimitrios Vavylonis’ sgroup of Lehigh University, revealed a critical role ofdynamic Talin unfolding in force transmission. Using
single-molecule speckle (SiMS) microscopy andsimulations, they showed evidence that molecularelasticity and stochastic coupling are necessary andsufficient to transmit the F-actin flow force to thesubstrate. This study offers a new mode of force
transmission, in which dynamic molecular stretchingbridges two cellular structures moving at different
speeds.

TOPICS

Force transmission via dynamic stretching of Talin as revealed by live-cellsingle-molecule imaging

For further information, please refer to the URL below.

https://www.nature.com/articles/s41467-023-44018-z
Lab URL

25

Graduate School of BIOSTUDIES, Kyoto University

http://www.pharm2.med.kyoto-u.ac.jp/

Graduate School of BIOSTUDIES, Kyoto University

26

Division of Systemic Life Science ｜ Department of Animal Development and Physiology (Collaboration Course)

Laboratory of
Molecular Cell
Biology andDevelopment
Visiting Professor

KITAJIMA, Tomoya

GBS’ s Collaboration Course in the RIKEN KOBE BDR

Main theme
Meiosis in oocytes is prone to chromosome
segregation errors and thus frequently
produces aneuploid eggs. The aneuploidy ofeggs is a leading cause of pregnancy loss andcongenital diseases such as Down syndrome.
We aim to understand the causes ofchromosome segregation errors in oocytes. We
will reveal molecular mechanisms of how
unique features of oocytes and age -related
effects predispose to chromosome segregation
errors. The mechanisms in oocytes will becompared with those in eggs and zygotes, bywhich we will understand differentiation of
intracellular mechanisms through development.
By understanding how aging affects
chromosome segregation in oocytes, we will
provide insights into how events at cell, tissue
and organ levels are interconnected at different
life stages.
Lab URL

Visiting Assoc. Prof.

TAKASATO, Minoru

OBATA, Fumiaki

Graduate School of BIOSTUDIES, Kyoto University

Lab URL

Visiting Assoc. Prof.

KONAGAYA, Yumi

We aim to uncover the molecular mechanisms
underlying the cell fate decision of intestinal epithelial
stem cells by live imaging of mouse intestinalorganoids, multiplexed tissue imaging, and quantitative
analyses at the single cell level.

Research subjects

・Investigation of the coordinated control of cellproliferation and differentiation in mouse intestinal
epithelium
・Analysis of the role of mechanical sensing in stem cellmaintenance in mouse intestinal epithelium
・Development of fluorescent reporters using machinelearning algorithms for protein structure prediction

An intestinal organoid expressing thecell cycle reporter FUCCI

https://sites.google.com/view/yumi-konagaya-lab-en

Lab URL

The shape of ovarian germ-line stem cell niche controls the reproductive capacity.
This work was published in PLoS Genetics on March 27, 2023.
A kidney organoid generated fromhuman pluripotent stem cells

Main theme

Lab URL

27

Prometaphase belt of chromosomes

https://www.bdr.riken.jp/en/research/labs/takasato-m/index.html

Nutrition and gut microbiota are vital players fororganismal homeostasis and therefore
influence our healthspan. Diet contributes tometabolic and physiological homeostasis byaltering nutritional balance and gut microbiota,
however our understanding of the molecularmechanism is far from complete. Ourlaboratory studies the functions of eachnutrient and gut bacterial species using amodel organism Drosophila melanogaster. We
also aim to elucidate mechanistically how
early -life diet alters life -long health. Our goal isto reveal evolutionally -conserved “dietological"
mechanisms that govern organismal ageing
and lifespan.

A Drosophila embryo during development

Drosophila intestine and gut microbiota

https://www.bdr.riken.jp/en/research/labs/obata-f/index.html

Stem cells are primitive cells that have potentials todifferentiate into various cells and to self-replicate forthe maintenance of tissue homeostasis. Such ability ofstem cells is controlled by a specific microenvironment
called “stem cell-niche” , which exists adjacent to stem
cells. In Drosophila ovary, niche cells stereotypicallybuild a dish-like structure and maintain only two or three
germ-line stem cells. However, it has been unclear how
the dish-like niche structure is built and how the shapecontributes to the stem cell system.
Tatsushi Igaki and Kiichiro Taniguchi in the laboratory ofgenetics found that the flies defective in cellcompetition, a type of cell-cell communication that
actively removes unfit cells, exhibited increased numberof germ-line stem cells and misshaped niche structure.
Mechanistically, we found that apoptosis in the cells
neighboring premature niche cells is required forshaping the dish-like structure of the niche. Intriguingly,

the egg production was diminished in the flies withmisshaped niche structure even though the number ofgerm-line stem cells was increased in the ovary. Our
study suggests that apoptosis driven by cellcompetition machinery contributes to shaping germ-line
stem cell niche for promoting the egg production.

TOPICS

Visiting Assoc. Prof.

KONDO, Takefumi

Main theme

Main theme

Lab URL

Embryonic development is a dynamic and beautiful
phenomenon that proceeds with remarkable precision.
Our goal is to elucidate the principles that ensure theaccuracy of the entire developmental process. We view
development as an information network system
consisting of multiple hierarchies of"genome"-"cell"-"tissue", and study its feedback
mechanisms between the layers by quantitatively
measuring and analyzing the dynamics at each layerusing techniques such as single cell genomics, imaging
and large-scale data analysis.

https://www.bdr.riken.jp/en/research/labs/kondo-t/index.html

http://chromosegr.riken.jp/index_en.html

We have developed a protocol generating
self-organizing kidney organoids from human
iPS cells. While these organoids comprise all
anticipated renal tissues, they are still far fromthe real human kidney in size, tissuecomplexity, maturity and functionality. We
study to achieve the ultimate goal of generating
functional and transplantable
three-dimensional urinary organoids, including
kidney and bladder. We appreciate knowledge
from basic developmental biology that isessential for such regenerative studies;
therefore, we are also highly interested instudies of human embryology. Particularly, we
are focusing on uncovering the developmental
mechanisms of the human urinary tract.

Visiting Assoc. Prof.

Main theme

Cell competition defect results in misshaped niche
structure and increased germ-line stem cells

For further information, please refer to the URL below.

https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010684

Graduate School of BIOSTUDIES, Kyoto University

28

Division of Systemic Life Science ｜Department of Signal Transductions

Division of Systemic Life Science ｜ Department of Signal Transductions

Laboratory of
Molecular
Neurobiology

Laboratory of
Genetics

Professor

Professor

KIMURA, Ikuo
Assist. Prof.

IKEDA, Takako

IGAKI, Tatsushi
Main theme
Our research aims at understanding themolecular mechanism of homeostasis
maintaining, especially focuses on
dietary/nutritional function, endocrine
metabolism, and cancer. Based on thisresearch, we aim to provide valuable
insight into the development of functional
foods, supplements, and medicinal drugs.

1. Dietary signaling via nutrient-sensing
receptors and metabolic syndrome
2. Non-genomic effects via sex steroid
hormone receptors and neurologicaldisorders

Main theme

Research subjects

Our research focuses on the molecular basisof cell-cell communication that governs tissue
growth, homeostasis, and cancer. We takeadvantage of the powerful genetics ofDrosophila.

1. Mechanism of cell competition

Assoc. Prof.

2. Genetic basis of tissue growth regulation

KANDA, Hiroshi

3. Molecular basis of tumor progression andmetastasis
4. Mechanism of aging

Assist. Prof.

ENOMOTO, Masato

Left: Polarity-deficient cells (green; losers) are eliminated from epithelium by wild-type cells (magenta;
winners) through cell competition.
Right:Malignant tumor cells (magenta) are invading and metastasizing from the eye disc to the brain (blue)
in Drosophila larva.

Lab URL

29

Graduate School of BIOSTUDIES, Kyoto University

http://www.biosystem.lif.kyoto-u.ac.jp/

https://igakilab.lif.kyoto-u.ac.jp/english/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

30Division of Systemic Life Science ｜Department of Biology Education and Heredity

Division of Systemic Life Science ｜ Department of Functional Biology

Laboratory of
Functional Biology

Assoc. Prof.

GUY, Adam Tsuda

Professor

ODA, Yukako
Assoc. Prof.

IMAMURA, Hiromi

Program-Specific Assist. Prof.

OGAWA, Keigo

Main theme[Oda Group] Cell-cell adhesion isessential for the construction ofmulticellular organisms. We aim toelucidate the regulatory mechanisms ofcell–cell adhesion in epithelial tissues tounderstand the construction,
maintenance, and repair mechanisms of
multicellular organisms. We focus on
peptides that induce cell–cell adhesion,
which we have recently identified. We
also aim to control various diseases
caused by disruption of intercellularadhesion, such as inflammation, cancer,
and aging, and to develop drug discovery.

Research subjects

・Induction and regulation of cell‒cell
adhesion・Control of malignant cancer byregulating cell‒cell adhesion
・Elucidation of stress response
mechanism in epithelial cells
・Understanding of the aging based on
the intestinal barrier function

Main theme

research. Our activities entail the following:

Our laboratory engages in the development andimplementation of new approaches to theinternationalization of science education andcommunication, based on principles of active
learning. The particular challenges we are
addressing often involve overcoming thedifferences in culture and pedagogicaltraditions between Japanese and Western
societies. Our efforts are chiefly in the
educational arena, aimed at training the next
generation of scientists to communicate theirknowledge and expertise not only to theinternational scientific community but locally tothe citizens who ultimately support basic

1. Increasing the exposure of Japanese
students to foreign peers. We are forging
new partnerships with foreign universities
to foster joint courses, using live Internet
connections, with active student
participation in English.

HEJNA, James Alan

2. Establishing partnerships with foreign
universities to encourage short-term
reciprocal exchanges of graduate students
for collaborative research.
3. Expanding the opportunities for students
to present their research in English to abroad audience.

・Metabolism of cancer cells

Assoc. Prof.

CARLTON, Peter

Main theme

Each cell adheres to form
epithelial cell sheet, epithelial
tissue(Upper) MDCKII cells(Bottom) Mouse small intestine
tissueTo create haploid gamete cells (sperm or egg
cells) from diploid precursors in meiosis,
homologous chromosomes must pair,recombine, and then separate from each other,
reducing the genome by half.
Recombination between homologous
chromosomes is initiated in meiotic
prophase by programmed DNA
double-strand breaks; these breaks are thenrepaired through homologous
recombination, giving rise to genetic
crossovers that link homologous
chromosomes until they divide.
Using the model organism Caenorhabditis
elegans, we are working to determine themolecular mechanisms of recombination
initiation and repair in the context ofchromosome dynamics, combining molecular
genetics, biochemistry and cytology with

Laboratory of
Chromosome
Functionand Inheritancehigh-resolution microscopy and quantitative
image analysis. Since errors during meiosis arecommon in humans and can lead to infertility
and developmental defects, understanding
these mechanisms is important for achieving
improvements in human reproductive health.
Our current research focuses on the following
areas:- Understanding mechanisms of programmed
DNA double-strand break initiation duringmeiosis- Phosphoregulation of the synaptonemal
complex- Analysis of chromosome structures using
super-resolution microscopy

https://www.carltonlab.org

Graduate School of BIOSTUDIES, Kyoto University

Specially Assigned Professor

・Technology to measure or manipulate
metabolism[Imamura Group] This group isdeveloping methods to measure ormanipulate metabolic states at asingle-cell level to understand themechanism behind cancer-specificmetabolism.

31

Laboratory of
ScienceCommunication

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

32

Division of Systemic Life Science ｜ Department of Systems Biology

Division of Systemic Life Science ｜ Department of Genome Biology

Laboratory of
GenomeMaintenanceLaboratory ofBrain Development
and Regeneration

Professor

Professor

IMAYOSHI, Itaru

Assoc. Prof. (Concurrent post)

GUY, Adam Tsuda

Assoc. Prof.

SAKAMOTO, Masayuki

MATSUMOTO, Tomohiro
Main theme
Our laboratory aims at understanding themechanisms of development andregeneration processes in the
mammalian brain, and their functional
outcomes on neural circuits, higher brain
functions, and animal behaviors. We arefocusing on the regulatory mechanism ofcell growth, differentiation, andquiescence of neural stem cells. We arealso focusing on the functional

contribution of newly-generated neurons
to neural circuits and animal behaviors.
Our laboratory is also developing novel
optogenetic tools that can manipulate
gene expression of cells by light.

Main theme
The spindle checkpoint, our major
research subject, is a surveillancemechanism to regulate cellular apparatus
for compliance with this rule. It is aunique negative feedback thatconverts/amplifies a physical signal
sensed by kinetochores (attachment of
the spindle and/or tension) and regulates
the timing of the sister chromatid
separation. Mad2, a signal carrier of thisfeedback, plays a vital role in the spindle
checkpoint. It is specifically localized atunattached kinetochores that are theorigin of the checkpoint signal. Mad2
targets CDC20 and inhibits its activity topromote sister chromatid separation. We
study Mad2, a central player of thespindle checkpoint, to reveal
mechanisms, which regulate the activityof Mad2.

Senior Lecturer

FURUYA, Kanji

Assist. Prof.

SUZUKI, Yusuke

Lab URL

33

Graduate School of BIOSTUDIES, Kyoto University

http://brainnetworks.jimdofree.com

http://www.rbc.kyoto-u.ac.jp/radiation_system/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

34

Division of Systemic Life Science ｜ Department of Genome Biology

Division of Systemic Life Science ｜ Department of Genome Biology

Laboratory of
Genome StressResponse

Laboratory ofCancer Cell Biology

Professor

Professor

YASUHARA, Takaaki
Assist. Prof.

MU, Anfeng

HARADA, Hiroshi
Main theme
Cells have sophisticated mechanisms to
respond to cellular stresses from external
stressors, thereby maintaining
homeostasis. Our laboratory aims to
elucidate the molecular mechanisms ofcellular stress responses, especially theones caused by genotoxic stresses, andthe fundamental mechanisms underlying
many types of diseases caused byinefficient stress responses. We hope tocontribute to solving various problems inthis age of long-life expectancy, such as
cancer and infertility in reproductive
medicine.

Research subjects

・The molecular mechanisms of cellularstress response
・Genomic instability induced byabnormal transcription-associated DNA
repair pathways
・The stress responses mediated byphase separation of RNA-binding
proteins
・Disease-related genome abnormalities
caused by aging
・The fundamental mechanism of
diseases, such as cancer andchromosomal anomaly

Main theme
Cells maintain their function andmorphology by exploiting a suitable
adaptive response system to diverse andcomplex tissue microenvironments.
Several lines of evidence have suggested
that hypoxic, acidic and nutrients-depleted
microenvironments exist in solid tumors
and induce malignant phenotypes andchemo/radioresistance of cancer cells(Figure 1). We aim to elucidate molecularmechanisms responsible for cellular

adaptive responses to the tumor-specificmicroenvironments and malignant
progression of cancer cells (Figure 2).

Assoc. Prof.

NAM, Jin-Min· Cellular adaptive responses to tumor
microenvironments, e.g. hypoxia· Molecular mechanisms underlying
malignant progression and chemo/
radioresistance of cancer cells· Regulatory mechanisms ofcarbohydrate metabolic pathway

・Cellular responses to replicative stress・Investigate mechanisms underlying rarediseases using iPS cells

Figure 1: Hypoxic tumor cells (green) distant from blood vessels (blue)
are resistant to radiation-induced DNA damage (red).

Top: Real-time imaging of R-loop
formation (green) at DNA
double-strand break sites(white arrows)
Bottom: Con d e n sate s (gre e n )formed at nucleoli(blue/magenta) upon
cellular stress
Figure 2: HIF-1-mediated gene networks responsible for both adaptive
responses to hypoxia and malignant progression of cancer cells.

Lab URL

35

Graduate School of BIOSTUDIES, Kyoto University

https://www.rbc.kyoto-u.ac.jp/genome_stress/en/

http://www.rbc.kyoto-u.ac.jp/cancer_biology/

Lab URL

Graduate School of BIOSTUDIES, Kyoto University

36

Division of Systemic Life Science ｜ Department of Genome Biology

Laboratory of
Chromatin
Regulatory
Network

Assoc. Prof.

Professor

IKURA, Tsuyoshi

TOMONAGA, Keizo

Main theme

Main research topics

Main theme

The purpose of our research is to clarify the roleof chromatin dynamics, which is required forthe DNA metabolisms such as transcription,
DNA replication, and DNA repair. In particular,
we focus on the molecular mechanisms bywhich histone modifier complexes regulate thehistone eviction as chromatin remodelingmachinery upon DNA damage induced byionizing radiation. Our goal is to understandhow histone eviction activates DNA damage
signaling pathways and functions as ananti-cancer signaling.

· Memory of genomic damage

All viruses utilize the mechanisms of infected
cells to replicate and propagate repeatedly.
Therefore, studying viruses is not only about
understanding them, but also about
uncovering the foundations of life more
broadly. In our laboratory, we investigate theinteraction between viruses and life, such as
how viruses replicate, why they cause
diseases, and how viral infections have
impacted our evolution. Additionally, we apply
the unique features of viruses to develop viral
vectors for gene and cell therapy. Specifically,
our research focuses on RNA viruses, suchas bornaviruses, influenza viruses and novel
coronaviruses.

· Cellular robustness in genomic stressresponse· Solution of energy metabolism
mechanism in specific cancer cell

Research subjects

http://house.rbc.kyoto-u.ac.jp/mutagenesis2/index1

For further information, please refer to the URL below.

thick biological samples, they still have much room for
improvement. The RFP developed in this study showed
the highest class of quantum yields reported for RFPs,
and its monomerized mutant was sufficiently bright for
fluorescence imaging, suggesting protein engineeringof GFPs as a promising way to createhigh-performance RFPs suitable for fluorescent tags.

・Investigation of the evolutionary
significance of endogenous RNA viruses.
・Development of novel viral vectors using
the Borna disease virus.

Assist. Prof.

MATSUGO, Hiromichi

Lab URL

Laboratory of
Cell Division and
TOYOSHIMA, FumikoDifferentiation

AFFILIATION：
Institute for Life and Medical Sciences

Main theme[Toyoshima Group] This group aims to clarify
the mechanism of organ remodeling during life
stages. In particular, we focus on organ
remodelling during pregnancy, obesity, andaging from the perspectives of tissue stem cell
dynamics, multicellular / multiorgan network,and mechanobiology. We also aim to apply themechanism of physiological organ remodelingto regenerative and anti-aging medicine.

3. Application of physiological organ
remodeling

Assoc.Prof.

VANDENBON, Alexis

to regenerative medicine
4. CriMGET system: Gene targeting
technology
5. Bioinformatics methodology for the
analysis of large biological datasets[Vandenbon Group] This group is developing
bioinformatics methodology for the analysis oflarge biological datasets, including single-celland spatial transcriptomics data.

Research subjects
Conversion of GFP into RFP

1. Maternal organ remodeling during
pregnancy and maternal-fetal interphase
2. Organ remodeling during obesity and aging

https://www2.infront.kyoto-u.ac.jp/Toyoshima-HP/index-En.html
Graduate School of BIOSTUDIES, Kyoto University

MAKINO, Akiko

Professor

This study was published in Proceedings of the National Academy of Sciences (PNAS) on November 7, 2023.
Fluorescent proteins, indispensable molecular tools inmodern biological research, form their chromophorethrough autocatalysis. Most of the fluorescent proteinsdiscovered in organisms have been green fluorescentproteins (GFPs). Although few in number, redfluorescent proteins (RFPs), which have structurally
different chromophores, are also known. Since GFPs
and RFPs are evolutionarily distant, it was thought tobe difficult to engineer a GFP into an RFP.
A research group led by Associate Professor Hiromi
Imamura of Graduate School of Biostudies, Kyoto
University, in collaboration with Professor Katsumi
Imada of Osaka University, has succeeded inconverting GFPs into RFPs by introducing mutations to
GFPs derived from coral. Structural analysis revealed
that the introduced mutations created a cavity wherean oxygen molecule, necessary for the RFP
chromophore formation, could bind.
Although RFPs are generally more suitable for imaging

Assoc. Prof.

・Analysis of the replication andpathogenicity of bornaviruses.

https://t.rnavirus.virus.kyoto-u.ac.jp/

Engineering the color of fluorescent proteins

https://doi.org/10.1073/pnas.2307687120

37

Laboratory of
RNA Viruses

AFFILIATION：
Institute for Life and Medical Sciences

Lab URLTOPICS

Division of Systemic Life Science ｜ Department of Mammalian Regulatory Network (Cooperation Course)

Lab URL
Graduate School of BIOSTUDIES, Kyoto University

38

Division of Systemic Life Science ｜ Department of Mammalian Regulatory Network (Cooperation Course)

Laboratory of
Cellular andMolecular
Biomechanics
Assist. Prof.

MAKI, Koichiro

ADACHI, Taiji

AFFILIATION：
Institute for Life and Medical Sciences

Main theme
Our group aims to clarify the mechanisms by whichcells sense mechanical stimuli and regulate theiractivities in stem cell differentiation, tissue/organ
morphogenesis, and functional adaptation. To better
understand how these dynamical processes aremechano-regulated through complex hierarchicalstructure-function relationships, we are bridging
spatial and temporal scales ranging from microscopic(molecular and cellular level) phenomena tomacroscopic (tissue level) behaviors. Based on
multiscale biomechanics integrating biomechanics
and mechanobiology researches, we combine
modeling and simulation with experiments toelucidate mechano-biochemical couplings in living
system dynamics.

・Biomechanics studies of functional adaptation inliving systems
・Multi-scale modeling of tissue development,
morphogenesis and growth・Mechanosensing mechanisms by osteocytic network
・Cell fate determination under mechanical environment
in a nucleus
・Bone remodeling and metabolism for multi-organinteraction

Main theme
Two-photon fluorescence microscopy has
become a powerful tool for deep imaging of
biological tissues. However, many biologicalphenomena in which intercellular interaction andcommunication networks play a crucial role areinvisible because of insufficient imaging
performance of commercial two-photon
fluorescence microscopes. We aim to make theinvisible visible by creating novel opticaltechniques. Our current research focuses on thefollowing subjects;

Program-Specific Professor

ISOBE, Keisuke

1. Development of femtosecond lasers forultra-deep imaging and their applications
2. Development of wide-field deep imaging
techniques using spatiotemporal control oflaser pulses and their applications
3. Development of 4-dimensional optical control
techniques using multiphoton patterned
illumination their applications

https://www2.infront.kyoto-u.ac.jp/bf05/index-e.html

Professor

NONOMURA, Keiko

AFFILIATION：
Institute for Life and Medical Sciences

Our group aims to clarify the molecularmechanism of mechanosensation and their
physiological roles among organs. For thispurpose, we utilize mice lacking PIEZO1/2
mechanically activated ion channels, theirreporter mouse lines, and also organoids.

Research subjects
1. Elucidating physiological roles of PIEZO
expressing mechanosensory neurons
innervating lung and/or other organs. We
have been specifically investigating theircontribution to breathing pattern ofnewborns, as starting breathing
immediately after birth is critical forsurvival of mammalian newborns and its
underlying mechanism is still mostly
elusive.

Graduate School of BIOSTUDIES, Kyoto University

2. Studying the contribution of PIEZO
mediated mechanisensation in the brain,focusing on both developmental process
and brain function.
3. Studying the mechanism in which PIEZO1
mediated mechanosensation contributes
to venous/lymphatic valve formation,utilizing KO or reporter mouse lines andcultured endothelial cells.

How bacterial toxin kills insect males efficiently
The findings were published in Current Biology on September 25, 2023.
Several symbiotic bacteria in insects selfishly
manipulate host reproduction. One such example ismale killing whereby male progeny is killed during
development. Recent successes in identifying the
responsible bacterial factors have enabled us toelucidate the molecular basis of this manipulative
phenotype. For instance, Spiroplasma, a bacterial
symbiont of the fruit fly Drosophila, selectively kills
males with a male-killing toxin Spaid (Spiroplasma
androcidin).
Assistant Professor Toshiyuki Harumoto (the laboratoryof Tadashi Uemura/the Hakubi Center) showed that the
Spaid protein stabilizes itself to facilitate male killing.
Without the stabilization mechanism, the male-killing

activity is attenuated, since Spaid is degraded throughthe host’ s proteolysis pathway. It was also shown that
Spaid stabilizes each other. Thus, the bacterial toxin
manipulates host reproduction at low cost.

TOPICS

Main theme

39

Laboratory of
Spatiotemporal
Optical Control

Professor

Lab URL

Laboratory of
Mechanosensory
Physiology

Division of Systemic Life Science ｜ Department of Advanced Imaging (Industry-Academia Collaboration Course)

Self-stabilization mechanism encoded by abacterial male-killing toxin Spaid

For further information, please refer to the URL below.

https://doi.org/10.1016/j.cub.2023.08.032

Graduate School of BIOSTUDIES, Kyoto University40Radiation Biology Center (RBC)
Radiation Biology Center, Kyoto University

Departments

Dept. of Radiation System Biology
We are pursuing mechanistic understanding of genetic and epigenetic inheritance by analyzing regulation of centromere
structure, various cell cycle check points, and stress responses.
[Staff]

MATSUMOTO, Tomohiro (Prof.) / FURUYA, Kanji (Senior Lecturer)

Dept. of Mutagenesis
How does the cell maintain its integrity in response to various stress such as radiation or UV? What kind of strategy is
employed? To solve these questions and to elucidate mechanisms of cancer or lifestyle-related disorders, we focus on
chromatin that is the characteristic of eukaryote's genome using proteomics analysis of chromatin regulator protein
complexes, bioimaging, and mathematical and statistic approaches.
[Staff]IKURA, Tsuyoshi (Assoc. Prof.)

Dept. of Late Effects Studies
We are studying the causes of diseases that occur after exposure to radiation, with a focus on DNA damage responses at thecellular level. An understanding of these molecular mechanisms will provide a deeper insight into the response of our body toradiation and will contribute to the fields of cancer and reproductive medicine.
[Staff]Message from Director of the Center

HARADA, Hiroshi

YASUHARA, Takaaki (Prof.) / MU, Anfeng (Assist. Prof.)

Dept. of Genome Repair Dynamics

Overview

The Radiation Biology Center (RBC) was founded in 1976 to promote

The research in the RBC is in large

basic research on biological effects of radiation. The RBC has been

We are conducting studies on intracellular and extracellular factors that affect cancer radiation sensitivity/resistance, suchas genetics deficiencies and tissue microenvironments. Our research focus is ranging from molecular, cellular, and tissuelevels to experimental mice and further to cancer patients.

part strongly linked with users offulfilling its responsibilities as a hub for scientists in radiation biology

the CORE Program, but at the same

[Staff]and its related research fields. The center was integrated with Graduate

time, each member of RBC pursues

School of Biostudies in 2018 to commence novel and deeper research
activities from this blessed position as a part of "Biostudies" looking

science with their own research
direction.

into the vast areas of life sciences.

HARADA, Hiroshi (Prof.) / NAM, Jin-Min (Assoc. Prof.) / KOBAYASHI, Minoru (Program-Specific Assist. Prof.)

Dept. of Chromosome Function and Inheritance
Using the model organism Caenorhabditis elegans, we are working to determine the molecular mechanisms ofrecombination initiation and repair in the context of chromosome dynamics. Understanding these mechanisms is important
for achieving improvements in human reproductive health problems such as infertility and developmental defects.
[Staff]CARLTON, Peter (Assoc. Prof.)

Reaserch Result
Aberrant activation of HIF-1 and p53 deficiency, which are both
recognized as hallmarks of cancers, induce malignancy andresistance to radiation therapy and chemotherapy.
But functional and mechanistic relationship remains unknown.
Department of Genome Dynamics found that ZBTB2 links
activation of hypoxia signaling and tumor suppressor dysfunction,
thereby promoting cancer aggressiveness, thus representing a
Low Dose and Low Dose-rate Irradiation System

Optical In Vivo Imaging System

The 2nd RBC-CEA Joint Workshop

target to treat p53-deficient cancers.
（Koyasu et al. EMBO Rep. 24:e54042. 2023.）

41

Graduate School of BIOSTUDIES, Kyoto University

Graduate School of BIOSTUDIES, Kyoto University

42

Center for Living Systems Information Science (CeLiSIS)
Center for Living Systems Information Science (CeLiSIS)

thereby leading data-driven life science. To achieve this goal,

Data Bank of Japan (DDBJ) at the National Institute of

CeLiSIS collaborates with the Center for Innovative Research

Genetics, and the University of Zurich.

and Education in Data Science (CIREDS), affiliated with theInstitute for Liberal Arts and Sciences, the core facility network
including the Innovative Support Alliance for Life Sciences(iSAL) and the North Campus Instrumental Analysis Station(NOCIAS), other graduate schools, and institutes across theuniversity campuses. Moreover, CeLiSIS interacts with otheradvanced external research organizations, including the DNA

Life science and related fields havegenome-related data from diverse species, ranging fromnow entered the era of "data-driven

microorganisms to animals and plants, has been rapidly

life science," which combines the

expanding. The training of young researchers to analyze suchacquisition of multifaceted large data

big data using informatics approaches has previously been

sets, using state-of-the-art equipment,

carried out separately by individual graduate schools or bywith analysis. This data-driven life

limited numbers of faculty members, and it has beenscience can be led by " two-way"challenging to strengthen education systems that integrate

human beings who not only acquire

the data acquisition and the information analysis. Therefore,

big data from biological samples, but

the Graduate School of Biostudies (GSB) has reorganized thealso analyze the data by themselves using informatics

Research Center for Dynamic Living Systems and establishedapproaches to extract, understand, and utilize the data to

the Center for Living Systems Information Science (CeLiSIS)

interpret the biological significance.

on April 1, 2023, to foster the training of "two-way" scientists

To date, the Research Center for Dynamic Living Systems has

on a university-wide basis. CeLiSIS also deals with data

played a major role in acquiring large amounts of image data

mining, statistics, mathematical modeling, in silico

using cutting-edge microscopy, analyzing this data tosimulations, and quantitative image analysis.

systematically understand biological phenomena, andCeLiSIS is the platform that consolidates and systematizes

providing practical education on informatics-based analyticalinformatics-based educational and research resources in life

methods. At the same time, however, gene analysis

science, which were previously scattered throughout Kyoto

instruments such as next-generation sequencers have been

University, and develops new programs in order to generate

developing dramatically, and their use has spread throughout

expert "two-way" researchers who can truly unite wet

life-science research; consequently, the volume ofexperimental approaches with informatics approaches,

From the left, a heatmap of gene expression analysis, a section of olfactory bulb, an image of neuronal primarily culture, a tSNE plot of single cell analysis.

43

Graduate School of BIOSTUDIES, Kyoto University• Basic course (master's degree equivalent)Students and technical staff at Kyoto University can learn
practical information analysis, based on their own
knowledge of experimental science.
• Life science DX course (doctoral course equivalent)This course fosters world-class “two-way” researchers.

Departments

Message from Director of the Center

UEMURA, Tadashi

Overview of educational activities

Strategic Education Program

Computational Genomics

This department plays a central role in consolidating andsystematizing educational and research resources thatwere scattered throughout Kyoto University, and inpromoting collaborations with other graduate schools,
institutes, university core facilities and externalorganizations to develop practical DX education
methods, together with other departments in CeLiSIS.

To extract biological significance from big data
generated by next-generation sequencers, curricula
related to UNIX, R, Python, statistical basics, and various
NGS analysis software are provided.

[Staff][Staff]

TOJU, Hirokazu (Prof.)
UEMURA, Tadashi (Prof.)
TANAKA, Noriko (Program-Specific Assoc.Prof.)
FUJITA, Hiroaki (Assist. Prof.)

TOJU, Hirokazu (Prof.)
YAMANO, Takashi (Assoc. Prof.)
HATTORI, Yukako (Assist. Prof.)
YOSHITAKE, Yoshihiro (Assist. Prof.)
INOUE, Keisuke (Assist. Prof.)
KUMETA, Masahiro (Assist. Prof.)
FUJITA, Hiroaki (Assist. Prof.)

Computational and Systems Biology

Advanced Big Data Analysis

This department provides curricula related toprogramming languages, ordinary differential equations,partial differential equations, basic statistics, linear
regression, nonlinear regression, machine learning,principal component analysis, and image analysis.

This department provides curricula related tomathematical modeling and predictive simulation, AI,data science related to single cell gene expression andgenome analysis, spatial transcriptomics, andlarge-scale database creation, as well as collaborative
research opportunities for doctoral students.

[Staff]

IMAYOSHI, Itaru (Prof.)
SAKAMOTO, Masayuki (Assoc. Prof.)
YOSHIMURA, Shigehiro (Assoc. Prof.)
IMAMURA, Hiromi (Assoc. Prof.)
USUI, Tadao (Senior Lecturer)
SUZUKI, Yusuke (Assist. Prof.)[Staff]

AOKI, Kazuhiro (Prof.)
TANAKA, Noriko (Program-Specific Assoc.Prof.)
KONDO, Yohei (Program-Specific Assoc.Prof.)

A class scene (an in-person exercise style)

Graduate School of BIOSTUDIES, Kyoto University

44

Data

As of April, 2024

Career Paths of the GSB Graduates
Number of Students（ ＝10）*Students who pass Interim Exam will recieve the master’ s degree.

total 263

Master’s Degree Holder
Employment

Promotion

58%

AY2023

Employment of Doctoral Degree Holder
Others38%

Academia

Industry

AY202333%

67%

AY202233%

67%

AY2021

33%

67%

4%

58%

AY2022
1st year

2nd year63

3rd year8840（ ＝10）

Number of International Students

Government-sponsored27

4th year

Personally funded

26

46

Japanese Students

52

4%

5th yeartotal 9

36%

7%

（ ＝5）

Number of Doctoral Degree Holder

International Students

2

57%

AY2021（ ＝1）

Number of Non-Degree Students

total 79

38%

AY20237

28

AY202224

AY202120

Major Places of Employment
Number of International Students
Asia
India
Korea
TaiwanChina
Pakistan
Viet Nam
Hong Kong
Malaysia
Mongolia
Singapore
Indonesia

1
4
9
32
1
2
1
4
6
1
1

AfricaSouth Africa
Kenya
RwandaEgypt
EuropeRussiaSwitzerland
Germany
FranceBulgaria

1
1
2
1

1
1
2

total 79
Middle East
LebanonMale-Female Ratio of Students(As of April 1 , 2024)

FemaleMale

1South America
Chile
1

Master’s

North America
Canada1
USA
1
Mexico2Doctorate

４４% (６６)
５４% (６０)

５６% (８５)
４６% (５２)

11*( )The numbers in parentheses indicate number of visiting academic staff.

* 〉
The numbers in brackets indicate affiliated academic staff, in addition to the regular staff.
Number of Faculty and Staff 〈Including specially contracted fixed-term faculty and staff

Faculty

Professor

17

（4）
〈9〉
45

total 59

Associate Professor Senior Lecturer Assistant Professor

21

（5）
〈3〉

Graduate School of BIOSTUDIES, Kyoto University

4

17

〈4〉

Staff

（ ＝10）

total 119

total 60

Administrative Staff Technical Staff

24

36

Private Campanies
ARKRAY, Inc. / AIREX INC. / AOYAMA & PARTNERS / Accenture Japan Ltd / ASAHI SOFT DRINKS CO. / ASAHI KASEI CORPORATION / ASAHI BREWERIES, LTD /AJINOMOTO CO.,INC. / Astellas Pharma Inc. / Nihon Emsco Co. Ltd. / AOHATA CORPORATION / ISHIHARA SANGYO KAISHA, LTD. / Idemitsu Kosan Co.,Ltd /SDS Biotech K.K. / NTT DATA CORPORATION / Osaka Gas Co., Ltd / Otsuka Pharmaceutical Co., Ltd. / Oyatsu Company Ltd. / Oriental Yeast Co., ltd. /OncoTherapy Science, Inc / GAKKEN HOLDINGS CO.,LTD. / Calbee, Inc. / Kawasumi Laboratories, Inc. / KEYENCE SOFTWARE CORPORATION. /KISSEI PHARMACEUTICAL CO., LTD. / Kyowa Kirin Co., Ltd. / KYOWA HAKKO BIO CO.,LTD. / KYORIN CO., LTD. / KYOKUTO PHARMACEUTICAL INDUSTRIAL CO., LTD /Creatures Inc. / GLICO NUTRITION CO.,LTD. / Gekkeikan Sake Company, Limited / KOSÉ Corporation / KOBAYASHI Pharmaceutical Co.,Ltd. /SAPPORO BREWERIES LTD. / Sunstar Inc. / Santen Pharmaceutical Co., Ltd. / Suntory Holdings Limited / SANYO FOODS Co.,Ltd. / GL Sciences Inc. /Genex Partners / Shionogi & Co., Ltd. / SYSMEX CORPORATION / Shiseido Company, Limited / CMIC CMO Co., Ltd. / CMIC HOLDINGS Co., Ltd. /Sumitomo Life Information Systems Co.,Ltd. / SEIWA KASEI Co,Ltd. / DAIICHI SANKYO HEALTHCARE CO., LTD. / DAIKIN INDUSTRIES, LTD. /Sumitomo Dainippon Pharma Co., Ltd. / Taiyo Kagaku Co.,Ltd. / Takanofoods Co., Ltd. / TAKARA BIO INC. / TAKII & CO.,LTD /Takeda Pharmaceutical Company Limited. / Chugai Research Institute for Medical Science, Inc. / CHUGAI PHARMACEUTICAL CO., LTD. /THE CHUGOKU ELECTRIC POWER CO.,INC. / TSUMURA & CO. / TEIKOKU SEIYAKU CO., LTD. / TEIJIN LTD. / TEIJIN FRONTIER CO., LTD. /Denka Company Limited. / DENTSU INC. / TOHO CO., LTD. / TOYO SHINYAKU Co.,Ltd. / SHIGA INTERNATIONAL PATENT OFFICE /TOYOTA MOTOR CORPORATION. / Torii Pharmaceutical Co., Ltd. / choseido Pharmaceutical Co.,Ltd. / Nikon Corporation / NICHIREI BIOSCIENCES INC. /Nissan Motor Co., Ltd. / Nisshin OilliO Group, Ltd. / NISSIN FOODS HOLDINGS CO., LTD. / NIPRO CORPORATION / Nihon M&A Center Inc. / Bank of Japan /NIPPON STEEL CORPORATION / NIDEC CORPORATION / JAPAN POST Co., Ltd. / NIHON L'ORÉAL K.K. / Net Protections, Inc. / Noevir Holdings Co., Ltd. /Nomura Securities Co.,Ltd. / HOUSE FOODS CORPORATION / Panasonic Corporation / East Nippon Expressway Company Limited / HIKARI TSUSHIN, INC. /Pigeon Corporation / Hitachi High-Tech Corporation / Fixpoint, Inc. / FUJIFILM Business Innovation Corp. / FUJIREBIO Inc. / BLEACH / Marudai Food Co.,Ltd. /Maruho Co., Ltd. / MANDA FERMENTATION CO.,LTD. / mandom corp. / Mizuno Corporation / Mizuho Financial Group, Inc. / Sumitomo Mitsui Card Co., Ltd. /MUFG Bank, Ltd. / Mediscience Planning Inc. / MORINAGA MILK INDUSTRY CO.,LTD. / Yakult Honsha Co.,Ltd. / Yahoo Japan Corporation / Euglena Co.,Ltd. /Eurofins Analytical Science Laboratories, Inc. / Yoshindo Inc. / Lion Corporation / Rakuten Group, Inc. / Recruit Co., Ltd. / Linical Co.,Ltd. /ROHTO Pharmaceutical Co.,Ltd. / Roche Diagnostics K.K / ROKKO BUTTER CO., LTD. / Works Applications Co.,Ltd. / WORLD INTEC CO.,LTD. / AGC Inc. /Cygames, Inc. / EY Strategy and Consulting Co., Ltd. / H.U. Group Holdings, Inc. / JCR Pharmaceuticals Co., Ltd. / JERA Co., Inc. / Mizkan Holdings Co., Ltd. /NBC Meshtec Inc. / NTT DOCOMO, INC. / The P&G Japan Limited / PwC. / SOLIZE Corporation / Waqoo,Inc. / WuXi Biologics.

OthersHokkaido University / The University of Tokyo / Kyoto University / Shiga University of Medical Science / Wakayama Medical University / Kumamoto University /Okinawa Institute of Science and Technology Graduate University (OIST) / Ministry of Education, Culture, Sports, Science and Technology /Ministry of Agriculture, Forestry and Fisheries / National Research and Development Agency RIKEN / Japan International Cooperation Agency /KYUSHU INTERNATIONAL UNIVERSITY HIGH SCHOOL. / Nara Institute of Science and Technology / Nagoya University / University College London /OSAKA UNIVERSITY.
Graduate School of BIOSTUDIES, Kyoto University

46

Professors Emeriti As of April 1, 2024

Total Revenue in Fiscal 2023
Category
Operational grants
MEXT Research Grants
Other Research Grants
Donations for Research
Funded Research
Collaborative Research
OthersTotal

NameTotal (yen)Total Revenue

227,205,674
425,672,860

Collaborative
Research

93,612,815
548,929,414
103,945,853

Biosignals and Response

Apr 1, 1999

Mar 31, 2001

Cell Recognition and Pattern Formation

Apr 1, 1999

Mar 31, 2002

OHYAMA, Kanji

Plant Molecular Biology

Apr 1, 1999

Mar 31, 2003

KUMAGAI, HidehikoApplied Molecular Microbiology

Apr 1, 1999

Mar 31, 2004

YANAGIDA, Mitsuhiro

Chromosome Transmission

Apr 1, 1999

Mar 31, 2005

IZUI, Katsura

Plant Physiology

Apr 1, 1999

Mar 31, 2005

NAKANISHI, Shigetada

NeuroscienceApr 1, 1999

Mar 31, 2005

YAMAMOTO, Kenji

Applied Molecular Microbiology

Apr 1, 1999

Mar 31, 2010

KOZUTSUMI, Yasunori

Membrane Biochemistry and Biophysics

Apr 1, 1999

Mar 31, 201228.31%TAKEYASU, Kunio

Plasma Membrane and Nuclear Signaling

Apr 1, 1999

Apr 30, 2014

MEXT
Research Grants

INOUE, Tan

Gene Biodynamics

Apr 1, 1999

Mar 31, 2015

INABA, Kayo

Immunobiology

Apr 1, 1999

Mar 31, 2016

YONEHARA, Shin

Molecular and Cellular Biology

Aug 1, 2001

Mar 31, 2018

SATO, Fumihiko

Molecular and Cellular Biology of Totipote

Aug 1, 1999

Mar 31, 2018

6.91%

1,503,570,282

36.51%

Funded Research

6.23%

1.03%

Donations for Research

Other Research Grants

Successive Deans As of April 1, 2024

NISHIDA, Eisuke

Signal Transduction

Apr 1, 1999

Mar 31, 2018

NEGISHl, Manabu

Molecular Neurobiology

Apr 1, 1999

Mar 31, 2019HEJNA, James Alan

Science Communication

Nov 1, 2010

Mar 31, 2020

CHISAKA, Osamu

Bioeducation

Apr 1, 1999

Mar 31, 2022

ISHIKAWA, Fuyuki

Cell Cycle Regulation

Sep 1, 2001

Mar 31, 2023

TAKATA, Minoru

Genome Damage Signaling

Apr 1, 2018

Mar 31, 2023

FUKUZAWA, Hideya

Applied Molecular Microbiology

Apr 1, 1999

Mar 31, 2023

MATSUDA, Michiyuki

Bioimaging and Cell Signaling
Center for Living Systems Information Science (CeLiSIS)

Apr 1, 2007

Mar 31, 2024

KAKIZUKA, Akira

Functional Biology

Apr 1, 2001

Mar 31, 2024

HonorsName

As of April 1, 2024

Periodfrom

to

OHYAMA, Kanji

Apr 1, 1999

Mar 31, 2001

YANAGIDA, Mitsuhiro

Apr 1, 2001

Mar 31, 2003

INABA, KayoApr 1, 2003

Mar 31, 2005

NISHIDA, Eisuke

Apr 1, 2005

Mar 31, 2009

YONEHARA, ShinApr 1, 2009

Mar 31, 2013

ISHIKAWA, Fuyuki

Apr 1, 2013

Mar 31, 2017

KAKIZUKA, Akira

Apr 1, 2017

Mar 31, 2021

FUKUZAWA, Hideya

Apr 1, 2021

Mar 31, 2023

IGAKI, Tatsushi

Apr 1, 2023

HonorsYear

INABA, Kayo2014

Japan Prize

TAKEICHI, Masatoshi

2005

The Order of Culture
The Order of the Sacred Treasure, Gold Rays with Neck Ribbon

Medal with Purple Ribbon

Person of Cultural Merit

Member of the Japan Academy
Graduate School of BIOSTUDIES, Kyoto University

Laureates

L Oréal-UNESCO For Women in Science International Awards

Japan Academy Prize

47

to

SASAKI, Ryuzo

Others 15.11%
Operational grants

88,703,666

from

TAKEICHI, Masatoshi

5.90%

15,500,000

Enrollment period

Laboratory

YANAGIDA, Mitsuhiro

2011

NAKANISHI, Shigetada

2015

INABA, Kayo2023

YANAGIDA, Mitsuhiro

2002

NISHIDA, Eisuke

2010

INABA, Kayo2016

MATSUDA, Michiyuki

2023

YANAGIDA, Mitsuhiro

2004

NAKANISHI, Shigetada

2006

YANAGIDA, Mitsuhiro

2003

OHYAMA, Kanji

2008

KUMAGAI, Hidehiko

2012

SATO, Fumihiko

2012

NISHIDA, Eisuke

2016

TAKEICHI, Masatoshi

2000

NAKANISHI, Shigetada

2009

Graduate School of BIOSTUDIES, Kyoto University

48