HYALURONIC ACID BENEFITS RESEARCH REPORT

Hyaluronic acid (HA) offers a range of benefits, particularly in skincare and medicalapplications:1. Skin Hydration:
One of the most well-known benefits of HA is its ability to retain moisture. HA
molecules have a unique capacity to hold water, making them highly effective inhydrating the skin. This property helps in maintaining skin moisture levels, resulting in aplump, supple, and youthful appearance.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8347214/
Conclusion from the above research report:The cosmetic industry is increasingly developing active cosmetic products andcosmeceuticals with hyaluronic acid (HA) and its derivatives, known for their hydrating,regenerating, and anti-aging properties. The efficacy of HA largely depends on its
molecular weight, necessitating further research on its metabolism and biologicaleffects. Despite their growing popularity, HA-containing products still make up a small
market share and often include additional active ingredients like plant extracts, vitamins,and peptides, which can enhance product claims but may also cause minor side effects.
Continued technological advancements are essential to fully realize HA's potential incosmetics.
2.Anti-Aging Properties:
HA plays a crucial role in maintaining skin elasticity and firmness. As we age, thebody's natural HA production decreases, leading to a loss of volume and the formationof wrinkles and fine lines. Topical application of HA can help diminish the appearance ofwrinkles and improve skin texture by replenishing lost moisture and supporting collagensynthesis. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583886/

Conclusion from the above research report :The data indicate that HA homeostasis varies significantly between intrinsic andextrinsic skin aging. To better manage skin moisture and improve treatments for skinaging, further research is needed to understand HA metabolism in skin layers and its
interactions with other skin components. This knowledge could enhance existing drugs
and lead to the development of new treatments for skin aging.
3.Wound Healing:
HA is involved in the wound healing process due to its ability to promote tissue repair
and regeneration. It creates a moist environment that accelerates wound closure andreduces the risk of infection. In medical settings, HA is used in various forms, such as
gels or dressings, to facilitate wound healing and improve outcomes after surgeries or
injuries. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065935/
Conclusion from the above research report :Hyaluronic acid (HA), a key component of the extracellular matrix (ECM), plays various
roles in wound healing, including promoting inflammatory cytokines, triggering
angiogenesis, and activating keratinocytes and fibroblasts. This study investigated theeffects of exogenously administered HA across a full spectrum of molecular weights(MW) and concentrations on wound healing factors both in vitro and in vivo. The results
showed that high molecular weight (HMW) HA significantly promoted fibroblast andkeratinocyte proliferation, enhancing granulation tissue formation. HMW HA alsoenhanced keratinocyte migration and upregulated genes such as IL-1β, IL-8, VEGF,
MMP-9, and MMP-13 in keratinocytes, suggesting its potential benefits for woundtreatment. However, fibroblasts did not show MW dependency, with significant gene
expression enhancement only for TGF-β1 by low molecular weight (LMW) HA. In vivo,
HMW HA effectively treated wounds in mice, likely through interactions with CD44 on
keratinocytes and fibroblasts. Future research should explore the relationship between
these effects and CD44-HA interactions.

4.Joint Health:In the field of orthopedics, HA injections are commonly used to alleviate symptoms ofosteoarthritis. HA acts as a lubricant and shock absorber in joints, reducing friction andimproving mobility. Intra-articular injections of HA can help reduce pain, inflammation,and stiffness associated with osteoarthritis, allowing patients to maintain an active
lifestyle. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469223/
Conclusion from the above research report:
Intra-articular hyaluronic acid is a valuable therapeutic option for managing
osteoarthritis. It appears to reduce pain and improve joint function while being highlytolerable. Additionally, it can prevent structural joint damage and delay the need forprosthetic surgery, making it a safe and effective long-term treatment.
5.Eye Health:
HA plays a vital role in maintaining eye health and lubricating the ocular surface. It ispresent in the vitreous humor and synovial fluid of the eye, providing hydration andlubrication to ocular tissues. In ophthalmic surgeries, such as cataract surgery or
corneal transplantation, HA-based viscoelastic solutions are used to protect delicate eye
structures and maintain intraocular pressure.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9790727/
Conclusion from the above research report:
Hyaluronic acid, in concentrations between 0.1% and 0.4%, is a safe and effective
treatment for dry eye disease (DED). It offers lubricating, anti-inflammatory, antioxidant,
and anti-toxic benefits at the ocular surface, improving both the signs and symptoms ofDED. Hypotonic HA drops may provide more clinical benefits compared to isotonic

drops, though further research is needed to understand the effects of tonicity. There is aneed for studies to determine the optimal HA concentration, drop frequency, molecularweight, and the best treatment approaches for different severities and sub-types ofDED.
6.Hair Health:
HA is also beneficial for hair health, as it helps hydrate the scalp and hair follicles,promoting hair growth and preventing dryness and breakage. HA-infused hair careproducts can nourish the scalp, improve hair texture, and enhance overall hair health.
Overall, hyaluronic acid offers a myriad of benefits for skin, joints, eyes, and hair,making it a versatile ingredient in skincare products and medical treatments. Its
hydrating and rejuvenating properties make it a popular choice for individuals seeking tomaintain youthful-looking skin and improve overall well-being.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8572598/
Conclusion from the above research report:
Overall, this study demonstrated that HYDRO DELUXE BIO (Matex Lab SpA) has dual
benefits: it protects dermal papilla cells from oxidative stress and increases VEGF
levels. Further in vivo experiments are needed to explore its potential for mesotherapy,
a minimally invasive technique using intradermal injections for medical and cosmeticapplications.
Conclusion:In conclusion, hyaluronic acid (HA) stands as a remarkable compound with multifaceted
benefits across various aspects of health and wellness. Its unique ability to retain
moisture, support tissue repair, and promote overall well-being makes it a valuableasset in skincare, wound healing, joint health, eye care, and hair health.

HA's role in skincare is particularly noteworthy, as it effectively hydrates the skin,diminishes the signs of aging, and enhances skin texture and elasticity. In medical
applications, HA demonstrates its efficacy in promoting wound healing, alleviating joint
pain, and ensuring optimal outcomes in ophthalmic surgeries. Additionally, HA
contributes to scalp and hair health, fostering hair growth and preventing dryness andbreakage.
The versatility and safety profile of HA make it a preferred choice for both consumers
and healthcare professionals seeking effective solutions for various health concerns. As
research continues to unveil its potential and refine its applications, hyaluronic acidremains at the forefront of innovation in the fields of dermatology, orthopedics,
ophthalmology, and beyond.
In essence, hyaluronic acid emerges not only as a cosmetic ingredient but also as avital component in medical treatments and wellness routines, empowering individuals toachieve healthier skin, joints, eyes, and hair. Its profound impact on health and beauty
underscores its significance in enhancing quality of life and inspiring confidence inindividuals worldwide.
*The information displayed herein has not been evaluated and/or approved in any formby the Japan Ministry of Health, FDA and/or similar body in Japan or elsewhere.