The World's First

Company to Quantify SmellKomi-hakko utilizes the technologies
we have developed in our research technologies such asodor analysis, fermentation, one-cell isolation,and ingredient analysis.
We support the development of productsthat are useful for consumers' lives.

World's First Odor Quantiﬁcation Technology
Quantifying how humans perceive odor components
The human olfactory receptor sensor
reproduces the mechanism of the human sense of smell.
Its greatest feature is that it can sense only theodors that humans perceive as humans perceive them.
A sensor using living cells requires cell culture technology and equipment.
However, in order to increase the portability of cell-based sensors,
we have developed a new technology cell-free handheld sensors
that reﬂect the response of human olfaction through AI.

What we can do by quantifying smells
By quantifying smells with ﬂavor fermentation
analysis technology, it is possible to develop
new products and technologies that have neverexisted before using smells.

What we can do by quantifying smells
By quantifying smells with Komi-Hakko analysis technology,
the following new products and technologies related to smells can be developed

New methods for odor control
We support product development using anunprecedented odor control method that targets
the receptors that respond to malodors.
*Antagonist deodorant that covers the receptors.
*Modulator deodorant that modulates
the receptor response

Reconstruction of odor by odor database
Create a database of fragrance odors andreconstruct the desired odor with a diﬀerent combinationof fragrances*Adding the sense of smell to VR with smell displays*TVs that emit smells*Real ﬂavors replacing rare natural and other ﬂavors*Learning ﬂavors that reconstitute toxic smells
with non-toxic ﬂavors*AI ﬂavoring that anticipates trends

Control of physiological activity by odor
We integrate data on the components and physiologicaleﬀects of fragrances used in aromatherapy with dataon the response of olfactory receptors,
enabling the development of fragrances foraromatherapy based on medical evidence.
*Fragrances that calm the mind
*Fragrances that enhance concentration*Fragrances that promote restful sleep

Check for signs of various diseasesIdentify receptors that respond to odors(urine, feces, body odor) that commonly appear
in patients with each disease, and support
the development of disease speciﬁc checkers.
*Infectious disease checker*Cancer checker*Parkinson's disease checker*Health Care Toilet

Standardization of Smell
By quantifying odors, we can accurately
communicate, compare, and evaluate them

Application to non-human olfactory receptors
The technology to quantify humanolfactory receptors can also be applied
to non-human receptors. This will support thedevelopment of eﬀective and safe new insect
repellents and attractants.
*Insect repellents and attractants for mosquitoes to preventthe transmission of diseases*Prevention of vermin through smells that animals do not like

Other developments
New technology and product development based on odor
quantiﬁcation has the potential to expand further.
*Quality control by quantifying smells*Development of a mechanical sensor that can express human senses

Komi-Hakko Corporation
HQ
550-0002 TAT Edobori Bldg 10F, Edobori 1-24-12, Nishi, Osaka, Osaka, Japan
Tel: +81-6-6443-3630 / FAX: +81-6-6443-3632
R&D565-0871 Technoalliance C Bldg 3F, Yamadaoka 2-8. Suita, Osaka, Japan
Tel: +81-6-6876-3385 / FAX: +81-6-6876-3386
Representative Director CEODirector CSO

Kenji KUBO
Shunichi KURODA, Ph.D.

2021,7,8In-house project

Reconstructing Odors, Real Flavors] Sample Completion
Vanilla ﬂavoring is made up of many diﬀerent ingredients,
but we are able to recreate those smells
with only three diﬀerent ﬂavors.
This allows us to reduce thecost of raw materials and theblending process.Real Flavor",
which reconstructs the realsmells that humans perceivewith other ingredients, reproduces
a variety of smells.

2021,5,14

In-house project

Sample of "receptor response inhibitor deodorizer" completed
Aroma Fermentation's original deodorant that suppresses the responseof receptors to eliminate bad odors has been completed.
You can experience a new deodorant that suppresses receptors
that respond to isovaleric acid,
which is the component of sweat odor
and natto odor.
We are already working with a numberof companies to develop such a
deodorant, and we expect it to beavailable soon.Our goal is to eventuallydevelop a deodorizer that can eliminate
all kinds of bad odors.

2021,5,14

In-house project

Reconstruction of Odor, Real Flavor] Sample Completion
Lavender and rose fragrances are composed of 30 to 50 diﬀerent ingredients,
but we are able to recreate those smells with only three fragrances.
This allows us to reduce the cost of raw materials and the process ofblending.Real Flavor", which reconstructs the real smells that humans
perceive with other ingredients, reproduces a variety of smells.

Selected for A-STEP, the Japan Science and Technology
Agency's Support Program for Optimum Deployment of Research Results

2021,5,14

In-house project[Reconstitution of odor and replacement of harmful substances]
Completion of the sample
The smell of camphor (camphor) is reconstituted without the use ofsubstances that are harmful to humans.Such technology can safely
convey what the smell of harmful substances smells like.
This technology can also be applied to
VR and other applications that reproduce avariety of scenes. It is possible to create
fragrances that match the image of dangerous
and harmful substances such as gunpowder,
gasoline, and putrid smells, as well as
imaginary creatures such as dragons andzombies.The range of applications is endless.

2021,5,14

Joint research and development

Hamaya Dried Bonito Flavor Interim Report Sample Completed
We have submitted the ﬁrst sample as an interim report for our joint research anddevelopment project with Hamaya Dried bonito ﬂavors using human olfactory
receptor response.It is a ﬂavor that reproduces the smell of bonito soup stock,which is made up of more than 400 ingredients, by synthesizing several ﬂavors
without using dried bonito ﬂakes. We will continue to develop this product in orderto replace it with a cheaper and safer substance and to achieve accuracy close
to that of the real ﬂavor.Our goal is to create a ﬂavor that can reproduce thearoma of Honkarebushi by simply adding a few drops to instant foods or hot water.
This product will be the ﬁrst of the "Real Flavor" products.

2019,10,1

Public funds, etc.

Selected for A-STEP, the Japan Science and Technology
Agency's Support Program for Optimum Deployment of Research Results
The Japan Science and Technology Agency (JST) has selected our company's"Creation of AI perfumer using human olfactory receptor sensor" for the 2019
A-STEP "Industry-Academia Collaboration Phase (Seeds Development Type)"
program. (140 million yen / 2.5 years)This will make it possible to reconstruct odors
objectively and more realistically without using sensory perception.A-STEP is atechnology transfer support program that aims to return research results tosociety by commercializing the results of scientiﬁc and technological research
conducted at universities and public research institutions as technologies that areimportant to the national economy.

human olfactory receptor sensor" for the 2019 A-STEP "Industry-Academia Collaboration Phase(Seeds Development Type)" program. (140 million yen / 2.5 years)This will make it possible to reconstruct odors
objectively and more realistically without using sensory perception.A-STEP is a technology transfer support
program that aims to return research results to society by commercializing the results of scientiﬁc andtechnological research conducted at universities and public research institutions as technologies that areimportant to the national economy.
Public funds, etc.

Received the 18th New Business Grant [New Business Grand Prize
We applied for the 18th New Business Grant sponsored by Senshu Ikeda Bank, and our"world's ﬁrst odor analysis service based on human olfactory receptors and odor databaseservice" was awarded the New Business Grand Prize of 3 million yen.
2017,10,30

Senshu Ikeda Bank's New Business Grant is designed to support
companies and entrepreneurs who have new and original businessplans and who aim to create innovations by themselves or incollaboration with other companies.