1-B-YIA1-1 一般演題（YIA）
Caveolin-1 modulates P2X7 receptor-dependent ATP signaling in proinflammatory macrophages.
Yuuki Sawai, Yoshiaki Suzuki, Rubii Kondo, Yuji Imaizumi, Hisao Yamamura
Dept. Mol & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA1-2 一般演題（YIA）
Possible role of food additives on formation of leptin resistance in obesity
Shibuya Yuki1, Kyoshiro Tsuge2, Karen Kuriya1, Tadashi Nakagawa1, Ralf Jockers3, Julie Dam3,
Akira Shimamoto2, Toru Hosoi11Dept. Clin. Pharmacology, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ., 2Dept. Regenerative Medicine
Research, Facul. Pharmaceutical Sci., Sanyo-Onoda City Univ., 3Inserm U1016, Institut Cochin, Dept
Endocrinology, Metabolism and Diabetes, Paris, France

Copyright © The Japanese Pharmacological Society1-B-YIA1-3 一般演題（YIA）
Identification of a novel circulating factor that denervate neuromuscularjunction in Amyotrophic lateral sclerosis (ALS) model mouse
Lili Quan, Shogo Tanabe, Rieko Muramatsu
Dept. Mol. Pharmacol., Natl. Inst. Neurosci., Natl. Center Neurol. Psychiat.

Copyright © The Japanese Pharmacological Society1-B-YIA1-4 一般演題（YIA）+

NAD level at a young age affects skeletal muscle functions at an old age
Mariam Karim, Takashi Nakagawa
Dept. Mol. Med. Pharmacol., Toyama Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA1-5 一般演題（YIA）
Insulin secretory and anti-apoptotic effect of apigenin on INS-ID pancreatic
β-cellIhim Stella, Yukiko Kaneko, Moe Yamamoto, Tomohisa Ishikawa
Dept. Pharmacol., Sch. Pharm. Sci., Univ. Shizuoka

Copyright © The Japanese Pharmacological Society1-B-YIA2-1 一般演題（YIA）
Crosstalk among the skeletal muscle, liver and adipose tissue on glycemic
control via peripheral sympathetic nervous system in rats and its
attenuation with high-fat diet
Daisuke Sato1, Nozomi Imaizumi1, Sae Itabashi2, Ryoichi Banno3,4, Masataka Kusunoki3,
Licht Miyamoto5
1Dept. Biochem. Eng. Yamagata Univ., 2Dept. Biochem. Eng. Yamagata Univ., 3Res. Ctr. Health Phys. Fitness Sports
Nagoya Univ., 4Dept. Diabetes Endocrinol. Nagoya Univ. Hosp., 5Dept. Nutr. Life Sci. Kanagawa Inst. Tech.

Copyright © The Japanese Pharmacological Society1-B-YIA2-2 一般演題（YIA）
Amitriptyline potentiates the expression of brain-derived neurotrophic factor
by enhancing downstream signal of lysophosphatidic receptors inconnexin43 knockdown astrocyte
Nozomi Tokunaga, Yoki Nakamura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA2-3 一般演題（YIA）
Synchronous firing promotes the formation of synaptic connectivity
contributes to the brain function
Kashima Tetsuhiko1, Takashi Yoshida2,3,4, Kenichi Ohki2,3,4, Yuji Ikegaya1,21Grad Sch. Pharma Sci, Univ. Tokyo, Tokyo, Japan,2Inst. for AI and Beyond, Univ. Tokyo, Tokyo, Japan,3Grad Sch.
Medicine, Univ. Tokyo, Tokyo, Japan,4WPI-IRCN, The University of Tokyo, Japan

Copyright © The Japanese Pharmacological Society1-B-YIA2-4 一般演題（YIA）
Investigating the effects of neurotrophin-3 overexpression on the
hippocampal dentate gyrus
Kasakura Nanami1, Yuka Murata1, Asuka Shindo1, Shiho Kitaoka2, Tomoyuki Furuyashiki3,
Kanzo Suzuki1, Eri Segi-Nishida11Dep. of Bio. Sci. and Tech., Tokyo Univ. of Sci.,2Dep. of Pharm., Hyogo Med. Univ., 3Div. Pharmacol., Grad. Sch.
Med., Kobe Univ

Copyright © The Japanese Pharmacological Society1-B-YIA2-5 一般演題（YIA）
Selective Rho-kinase 2 inhibitor ameliorates the decreased spine density inthe medial prefrontal cortex of mice carrying the variants of Arhgap10 genefound in a Japanese schizophrenia patient
Rinako Tanaka1, Wenjun Zhu1, Daisuke Mori2, Akihiro Mouri3, Taku Nagai4,
Toshitaka Nabeshima5, Kozo Kaibuchi6, Daiki Tachibana7, Yohei Kobayashi7, Norio Ozaki2,
Hiroyuki Mizoguchi1, Kiyofumi Yamada1
1

Dept. of Neuropsychopharmacol. & Hosp. Pharm., Nagoya Univ. Grad. Sch. of Med., Nagoya, Japan,
Pathophysiol. of mental disorders, Nagoya Univ. Grad. Sch. of Med., Nagoya, Japan, 3Dept. of Regulatory Sci. for
Evaluation & Development of Pharmaceut. & Devices, Fujita Health Univ. Grad. Sch. of Health Sci., Toyoake,Japan, 4Div. of Behavioral Neuropharmacol., International Ctr. for Brain Sci. (ICBS), Fujita Health Univ., Toyoake,Japan, 5Lab. of Health & Med. Sci. Innov., Fujita Health Univ. Grad. Sch. of Health Sci., Toyoake, Japan,6Div. of
Cell Biol., ICBS, Fujita Health Univ., Toyoake, Japan, 7Pharmacol. Res. Unit, Sumitomo Pharma Co., Ltd., Osaka,Japan
2

Copyright © The Japanese Pharmacological Society1-B-YIA3-1 一般演題（YIA）
Evaluation of approach and avoidance behavior in a three-compartment
conflict task in mice.
Natsuko Hitora-Imamura1,2, Yuki Honshuku1,2, Yurika Miyagami2, Aoi Mori2, Hiroshi Nomura2,3,
Masabumi Minami2
1Fac. Life Sci., Kumamoto Univ., 2Dept. of Pharmacol., Grad. Sch. of Pharmaceut. Sci., Hokkaido Univ., 3Dept.
Cognitive Funct. & Pathol., Grad. Sch. Med. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA3-2 一般演題（YIA）
Characteristics of depression model mice produced by repeatedadministration of dexamethasone after lipopolysaccharide-induced
inflammation
Fumiya Shibagaki, Naoko Kojima, Akane Furukawa, Noritaka Nakamichi
Lab. Mol. Pharmacother., Fac. Pharm., Takasaki Univ. Health and Welfare

Copyright © The Japanese Pharmacological Society1-B-YIA3-3 一般演題（YIA）
The effect of diazepam on aggressive biting behavior of isolation-reared ddYmouse is different between male and female.
Kento Igarashi1,2, Satoshi Kuchiiwa3, Toshiko Kuchiiwa4, Koh-ichi Tanaka1,2, Junichi Kitanaka2,
Nobue Kitanaka5, Nobuyoshi Nishiyama2, Kazuo Tomita1,2, Tomoaki Sato1
1

Dept. Applied Pharmacol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 2Dept. Pharm., Sch. Pharm., Hyogo
Med. Univ., 3Dept. Morphol. Sci., Field of Neurol., Grad. Sch. Med. & Dent. Sci., Kagoshima Univ., 4Dept. ofClinical Pshychol., Grad. Sch. Human Sci., Kagoshima Immaculate Heart Univ., 5Dept. Pharmacol., Sch. Med.,
Hyogo Med. Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA3-4 一般演題（YIA）
Involvement of fatty acid-binding protein 3 in the mechanism forexacerbation of postoperative pain of high fat-induced obesity model mice
Dan Tachibana, Kazuo Nakamoto, Shogo Tokuyama
Dept. Clin. Pharmacy, Sch Pharmaceu. Sci., Kobe Gakuin Univ.

Copyright © The Japanese Pharmacological Society1-B-YIA3-5 一般演題（YIA）
Detection of the proteins in a unique extracellular fluid of the mouse innerear
Fukuda Masatoshi1,2, Hiroki Okanishi3, Daisuke Ino1, Eri Wakai1, Yumi Ohta2, Takashi Sato2,
Hidenori Inohara2, Yoshikatsu Kanai3, Hiroshi Hibino1
1

Division of Glocal Pharmacology, Department of Pharmacology, Graduate School of Medicine, 2Department ofOtorhinolaryngology, Graduate School of Medicine, Osaka University, 3Department of Bio-syastem Pharmacology,
Graduate School of Medicine

Copyright © The Japanese Pharmacological Society2-B-YIA4-1 一般演題（YIA）
Finerenone-induced cardioprotective effects associated with the
suppression of myocardial sodium buildup in salt/aldosterone-loaded
uninephrectomized rats
Rahman Asadur1, Tatsuya Sawano2, Kento Kitada1, Takeshi Imamura2, Akira Nishiyama1
1

Department of Pharmacology, Faculty of Medicine, Kagawa University, Japan, 2Division of Pharmacology,
Faculty of Medicine, Tottori University, Japan.

Copyright © The Japanese Pharmacological Society2-B-YIA4-2 一般演題（YIA）

Copyright © The Japanese Pharmacological Society2-B-YIA4-3 一般演題（YIA）
Vascular endothelial dysfunction is involved in the fluoroquinoloneassociated aortic aneurysm and dissection
Miyata Koji1, Yuki Izawa-Ishizawa1,2, Honoka Nishi1, Shuto Itokazu1, Tatsumi Miyata1,
Kaito Tsujinaka1,3, Masateru Kondo1,3, Takahiro Niimura1,4, Fuka Aizawa1,3, Kenata Yagi1,4,
Kei Kawada1,5, Mitsuhiro Goda1,3, Keisuke Ishizawa1,3,4
1

Dept. Clin. Pharmacol. & Therap., Tokushima Univ., 2Dept. Gen. Med., Taoka Hosp., 3Pharm., Tokushima Univ.
Hosp., 4Clin. Res. Ctr. Dev. Therap., Tokushima Univ. Hosp.,5Dept. Pharm. Pract. Pedagog., Tokushima Univ.

Copyright © The Japanese Pharmacological Society2-B-YIA4-4 一般演題（YIA）
RAMP1 signaling attenuates acute lung injury by inhibiting cytokine
production and neutrophil recruitment.
Yamashita Atsushi1,2, Yoshiya Ito1, Hiromi Matsuda2, Mayuko Osada1, Seishiro Akinaga1,
Mariko Kamata1, Kanako Hosono1, Ko Hatanaka1, Masataka Majima1,3, Hirotsugu Okamoto2,
Hideki Amano1
1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Anesthesiology, Sch. Med., Kitasato Univ., 3Fac. Health & Med.
Sci., Kanagawa Inst. Tech.

Copyright © The Japanese Pharmacological Society2-B-YIA4-5 一般演題（YIA）
Overexpression of aquaporin-5 (AQP5) in pulmonary epithelial cells
suppresses sepsis-induced edema by inhibiting epithelial apoptosis
Ishii Shinya, Yuta Uchiyama, Kazuhito Murakami, Yoichiro Isohama
Lab. of appl. pharmacol., Fac. of Pharm. of Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society2-B-YIA5-1 一般演題（YIA）
Pemigatinib suppresses liver fibrosis and subsequent osteoporosis
Mihara Taiki1, Yoshiharu Tsuru2, Tamaki Kurosawa1, Yuma Nonoshita1, Yuki Yamakawa1,
Masatoshi Hori1
1

Laboratory of Veterinary Pharmacology, Graduate School of Agriculture and Life Sciences, The University ofTokyo, 2Research Support Dev., PRIMETECH Corp.

Copyright © The Japanese Pharmacological Society2-B-YIA5-2 一般演題（YIA）
Thromboxane A2 receptor signaling in macrophages promotes liver repair
after acetaminophen-induced liver injury
1

1

1

1

1

1

Mina Tanabe , Yoshiya Ito , Mayuko Osada , Takuya Yamazaki , Yu Kuroda , Mariko Kamata ,1
1
2
1
Kanako Hosono , Kou Hatanaka , Masataka Majima , Hideki Amano1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Fac. HealthMed. Sci., Kanagawa Inst. Tech.

Copyright © The Japanese Pharmacological Society2-B-YIA5-3 一般演題（YIA）
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage
Recruitment and Polarization
Tian Lan1, Xiang Zhang2, Shiyun Chen1, Xin Ding1
1

Guangdong Pharmaceutical University, 2The Chinese University of Hong Kong

Copyright © The Japanese Pharmacological Society2-B-YIA5-4 一般演題（YIA）
Establishment of gall bladder organoid derived from cholesterol-inducedcholelithiasis model mouse
Yamamoto Haru, Maria Mochizuki, Tatsuya Usui, Kazuaki Sasaki
Lab. Vet Pharm., Dept Vet Med., Tokyo Agri. & Tech. Univ.

Copyright © The Japanese Pharmacological Society2-B-YIA5-5 一般演題（YIA）
Nivolumab receptor occupancy on effector regulatory T cells predicts
clinical benefit
Hosonuma Masahiro1,2,3,4, Yuya Hirasawa4, Atsuo Kuramasu2, Yuta Baba2, Toshiaki Tsurui1,2,3,
Takuya Tsunoda4, Yuji Kiuchi1,2,3, Kiyoshi Yoshimura2,4
1

Division of Medical Pharmacology, Department of Pharmacology, Showa University School of Medicine,
Department of Clinical Immuno Oncology, Clinical Research Institute for Clinical Pharmacology andTherapeutics, Showa University, 3Pharmacological Research Center, Showa University, 4Division of Medical
Oncology, Department of Medicine, Showa University School of Medicine
2

Copyright © The Japanese Pharmacological Society2-B-YIA6-1 一般演題（YIA）+

CCR5 cells possibly contribute to development of lung fibrosis in asthma
Shimora Hayato, Yukino Nagatani, Itomi Takamori, Keitaro Nishikawa, Masaya Matsuda,
Kazuyuki Kitatani, Takeshi NabeLab. of Immunopharmacol., Fac. of Pharm. Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society2-B-YIA6-2 一般演題（YIA）
AMPK/mTOR signaling pathway attenuates subtype-selective differentiationof Myeloid-Derived Suppressor Cells (MDSC)
Sugiyama Shintaro, Kazuhito Murakami, Yoichiro Isohama
Lab. of appl. Pharmacol., Fac. of Pharm. of Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society2-B-YIA6-3 一般演題（YIA）
Ferroptosis induced by eribulin and its mechanism in ovarian cancer cells
Mana Azumi1, Mikihiro Yoshie1, Kazuya Kusama1, Saya Nakano1, Atsuya Tsuru1,
Tomoyasu Kato1,2, Kazuhiro Tamura1
1Dept. Endocrine Pharmacol. Tokyo Univ. Pharmacy and Life Sci., 2Div. Gynecol., Natl. Cancer Ctr. Hosp.

Copyright © The Japanese Pharmacological Society2-B-YIA6-4 一般演題（YIA）
Mechanism and pathological significance of cysteine metabolic
reprogramming associated with hepatocarcinogenesis
Yamauchi Tomoaki1, Yumi Okano1, Daisyu Terada1, Akito Tsuruta1,2, Satoru Koyanagi2,
Shigehiro Ohdo1
1

Dept. of Pharmaceutics, Grad. Sch. Pharm., Kyushu Univ., 2Dept. Glocal Healthcare Sci., Grad. Sch. Pharm.,
Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-B-YIA6-5 一般演題（YIA）
Development of deep learning methods for multiple mice tracking
Naoaki Sakamoto1, Hitoshi Kakeno1, Noriko Ozaki1, Yusuke Miyazaki1, Koji Kobayashi2,
Takahisa Murata1,2,3
1

Dept. Animal Radiolody., Grad. Agr. & Life Sciences. Univ of Tokyo,2Crs. Food and Animal Systemics., Grad. Agr.
& Life Sciences. Univ of Tokyo, 3Dept. Veterinary Pharmacol, Grad. Agr. & Life Sciences. Univ of Tokyo

Copyright © The Japanese Pharmacological Society1-B-O01-1

一般演題（口頭）
18

Crystal structures of monoamine oxidase-B with PET ligands [ F]SMBT-1/
18[ F]THK5351
Ryuichi Harada1,2, Kaede Goto3, Kaede Kudo2, Yukitsuka Kudo2, Takeshi Yokoyama3,
Shozo Furumoto4, Nobuyuki Okamura5, Yoshikazu Tanaka3
1

Tohoku Univ. Sch.Med. Pharmacol., 2Tohoku Univ. IDAC, 3Tohoku Univ. Sch. Life., 4Tohoku Univ. CYRIC, 5Tohoku
Med. and Pharm. Univ. Sch. Med. Pharmacol.

Copyright © The Japanese Pharmacological Society1-B-O01-2 一般演題（口頭）A trans-omic analysis of metformin action in the liver
Katsuyuki Yugi
RIKEN IMS

Copyright © The Japanese Pharmacological Society1-B-O01-3 一般演題（口頭）Sialic acid degradation in the inflamed skin attenuates the number of theepidermal nerve fibers and inflammatory pain via calcitonin gene related
peptide receptors
Shun Watanabe1,2, Ruka Saito1,2, Marie Abe1,2, Misa Oyama1,2, Takashi Iwai1,2, Mitsuo Tanabe1,2
1Lab. Pharmacol., Sch. Pharmaceut. Sci., Kitasato Univ., 2Med. Res. Lab., Sch. Pharm., Kitasato Univ.

Copyright © The Japanese Pharmacological Society1-B-O01-4 一般演題（口頭）
Increasing CD11c+ microglia cells facilitates the resolution of neuropathic
pain behavior
Kohno Keita, Ryoji Shirasaka, Keita Hirose, Yuto Shibata, Makoto Tsuda
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu
University

Copyright © The Japanese Pharmacological Society1-B-O01-5 一般演題（口頭）The involvement of spinal glial cell-derived lipocalin2 in the development ofcentral post-stroke pain
Kazuo Nakamoto, Atsushi Ueda, Dan Tachibana, Shogo Tokuyama
Dept. Clin. Pharm., Sch. Pharmaceu. Sci., Kobe Gakuin Univ.

Copyright © The Japanese Pharmacological Society1-B-O02-1 一般演題（口頭）
Antioxidant mechanisms of hypotaurine by an action of taurine transporter(TauT) in hamster sperm
Takei Gen L.1, Yasuhiro Horibata2, Fubito Toyama3, Keitaro Hayashi1, Asuka Morita1,
Motoshi Ouchi1,4, Tomoe Fujita1
1

Dept. Pharmacol. Toxicol., Dokkyo Medical Univ., 2Dept. Biocheml., Dokkyo Medical Univ., 3Sch. Engr.,
Utsunomiya Univ., 4Grad. Sch. Nsg., Chiba Univ.

Copyright © The Japanese Pharmacological Society1-B-O02-2 一般演題（口頭）Structural complexity and dynamics in GPCRs revealed by vibrational
spectroscopy
Kota Katayama1,2, Kohei Suzuki1, Ryoji Suno3, Hideki Kandori1,2
1

Nagoya Institute of Technology, 2OptoBioTechnology Research Center,3Kansai Medical University

Copyright © The Japanese Pharmacological Society1-B-O02-3 一般演題（口頭）Regulatory mechanism of immediate early G protein-coupled receptor 3
gene expression during neuronal differentiation in PC12 cells
Shigeru Tanaka, Kouta Narai, Fumiaki Ikawa, Hiroko Shiraki, Kana Harada, Izumi Hide,
Norio Sakai
Hiroshima Univ. Grad. Sch. of Biomed & Health Sci., Dept. Mol. & Pharmacol. Neurosci.

Copyright © The Japanese Pharmacological Society1-B-O02-4 一般演題（口頭）NCX3 deficiency in the prefrontal cortex induces hyperactivity and social
deficits via aberrant dopaminergic neurotransmission
Ryo Inagaki1, Satomi Kita2, Nozomu Niwa1, Takahiro Iwamoto3, Kohji Fukunaga4,
Shigeki Moriguchi1
1

Research Center for Pharmaceutical Development, Graduate School of Pharmaceutical Sciences, Tohoku
University, Sendai, Japan., 2Department of Pharmacology, Faculty of Pharmaceutical Sciences, Tokushima Bunri
University, Tokushima, Japan, 3Department of pharmacology, Faculty of Medicine, Fukuoka University, Fukuoka,
Japan., 4BRI Pharma Inc.

Copyright © The Japanese Pharmacological Society1-B-O02-5 一般演題（口頭）Elucidation of the evolutionary conservation of the central serotonergic
system in chicken by molecular dissection
Toshiyuki Fujita, Shinji Yamaguchi
Teikyo Univ.

Copyright © The Japanese Pharmacological Society1-B-O03-1 一般演題（口頭）Effects of a novel RyR2 specific inhibitor on arrhythmias incatecholaminergic polymorphic ventricular tachycardia (CPVT) model mice
Nagomi Kurebayashi1, Masami Kodama1,6, Takashi Murayama1, Ryosuke Ishidaishida2,
Shuichi Mori2, Masami Sugihara3, Masato Konishi1, Aya Miura4, Hajime Nishio4, Yukiko
U. Inoue5, Takayoshi Inoue5, Satoru Noguchi5, Kazuho Sakamoto6, Junko Kurokawa6,
Hiroyuki Kagechika2, Takashi Sakurai11

Dept Pharmacol, Juntendo Univ Sch Med, 2Inst Biomat Bioeng, TMDU, 3Dept Clin Lab Med, Juntendo Univ Sch
Med, 4Dept Leg Med, Hyogo Med Univ, 5Natl Inst Neurosci, NCNP, 6Dept Bio-Informational Pharmacol, Sch
Pharmaceut Sci, Univ Shizuoka

Copyright © The Japanese Pharmacological Society1-B-O03-2 一般演題（口頭）Excitation-transcription coupling in smooth muscle is associated with
vascular remodeling
Yoshiaki Suzuki1, Masatake Araki2, Kimi Araki2, Gerald Zamponi3, Wayne Giles3, Yuji Imaizumi1,
Hisao Yamamura1
1Dept. Mol & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Institute of Resource
Development and Analysis, Kumamoto University, 3Cumming School of Medicine, University of Calgary

Copyright © The Japanese Pharmacological Society1-B-O03-3 一般演題（口頭）Molecular dynamics simulation study for the molecular instability of NBD1 of
CFTR induced by disease-associated mutations causing Cystic Fibrosis inJapanese patients.
Hikaru Sohma1, Rio Kimishima1, Tadaomi Furuta2, Yoshiro Sohma1
1

Div Mol Ther, Grad Sch Pharm, IUHW, Ohtawara, Japan, 2Sch Life Sci Tech, Tokyo Inst Tech, Yokohama, Japan

Copyright © The Japanese Pharmacological Society1-B-O03-4 一般演題（口頭）
Expression of Smoc2, a matricellular protein, in the cochlea of the
mammalian inner ear
Ono Kazuya1, Takeru Ota1, Yoshifumi Takahata2, Riko Nishimura2, Hiroshi Hibino1
1Div. Glocal. Pharmacol., Dept. Pharmacol. Grad. Sch. Med. Osaka Univ., 2Dept. Mol. Cell. Biochem. Grad. Sch.
Dent. Osaka Univ.

Copyright © The Japanese Pharmacological Society1-B-O03-5

一般演題（口頭）++

Physiological and pharmacological properties of a novel H ,K -ATPase
ATP13A2 in neuronal lysosomes
Takuto Fujii1, Shushi Nagamori2, Pattama Wiriyasermkul2, Takahiro Shimizu1, Yoshiaki Tabuchi3,
Tomoyuki Okumura4, Tsutomu Fujii4, Hiroshi Takeshima5, Hideki Sakai1
1Dept. Pharmaceut. Physiol., Fac. Pharmaceut. Sci., Univ. Toyama., 2Ctr. SI Med. Res., Jikei Univ. Sch. Med., 3Div.
Mol. Gen. Res., Life Sci. Res. Ctl., Univ. Toyama, 4Dept. Surg. Sci., Fac. Med., Univ. Toyama, 5Dept. Biol. Chem.,
Grad. Pharmaceut. Sci., Kyoto Univ.

Copyright © The Japanese Pharmacological Society2-B-O04-1 一般演題（口頭）The potential effects of single dose of melatonin on learning and memory
function
Sano Masahiro, Kohji Fukunaga, Ichiro Kawahata
Dept. of CNS drug innov., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society2-B-O04-2 一般演題（口頭）PKB/AKt pathway involves in facilitation of inhibitory synaptic transmission
by insulin in the insular cortex
Yuka Nakaya1, Satomi Kobayashi1,2, Kouhei Kitano1, Masayuki Kobayashi11Dept. Pharmacol. Nihon Univ. Sch Dent., 2Dept. Biol. Nihon Univ. Sch Dent.

Copyright © The Japanese Pharmacological Society2-B-O04-3 一般演題（口頭）Single-molecule imaging within brain tissue
Yohei Okubo1, Shigeyuki Namiki2, Daisuke Asanuma2, Takashi Sakurai1, Kenzo Hirose2
1

Dept. Pharmacol., Fac. Med., Juntendo Univ., 2Dept. Pharmacol., Grad. Sch. Med., Univ. Tokyo

Copyright © The Japanese Pharmacological Society2-B-O04-4 一般演題（口頭）Abnormal shortening of hippocampal telomere in an animal model ofdepression
Hiroki Shikanai1,2, Tsugumi Shindo1, Kazune Ozaki1, Atsuko Ohashi1, Ikuo Otsuka3,
Akitoyo Hishimoto3, Takeshi Izumi1,2
1

Dept. Pharmacol., Fac. Pharmaceut. Sci., Health Sci. Univ. Hokkaido, 2Adv. Res. Promotion Ctr., Health Sci. Univ.
Hokkaido, 3Dept. Psychiatry, Kobe Univ. Grad., Sch., Medicine

Copyright © The Japanese Pharmacological Society2-B-O04-5 一般演題（口頭）Induction of LTP of inhibitory synapses from parvalbumin-immunopositive
neurons to pyramidal neurons using optogenetics
Kobayashi Satomi1,2, Satoshi Fujita2, Masayuki Kobayashi11Dept. Pharmacol., Nihon Univ. Sch. Dent., 2Dept. Biol., Nihon Univ. Sch. Dent.

Copyright © The Japanese Pharmacological Society2-B-O05-1 一般演題（口頭）Galectin-1-elicited axonal regeneration in the brains and memory recovery
effects in Alzheimer‘s disease model mice
Yang Ximeng, Chihiro Tohda
Section of Neuromedical Science, Inst. of Natural Med., Univ. of Toyama

Copyright © The Japanese Pharmacological Society2-B-O05-2 一般演題（口頭）Mechanism of necrotic tissue drainage after cerebral ischemia
Toshinori Sawano1, Haiyang Sun1, Momoka Okada1, Jin Nakatani1, Shinobu Inagaki2,3,
Takayuki Nakagomi4,5, Tomohiro Matsuyama5, Hidekazu Tanaka1
1

Pharmacol. Lab., Dept. Biomed. Sci., Ritsumeikan Univ., 2Dept. Child Dev. and Mol. Brain. Sci., United Grad. Sch.
Child Dev., Osaka Univ., 3Dept. PT., Yukioka Col. Health Sci., 4Lab. Neurogenesis and CNS Repair., Inst. Adv. Med.
Sci., Hyogo Med. Univ., 5Dept. Therap. Prog. Brain Dis., Hyogo Med. Univ.

Copyright © The Japanese Pharmacological Society2-B-O05-3 一般演題（口頭）P.gingivalis promotes influx of amyloid beta into the brain via
cerebrovascular endothelial cells
Zhou Wu1,2, Fan Zeng3, Shuge Gui4, Shinsuke Mizutani2,5, Haruhiko Kashiwazaki5
1Dept. Cell Biol., Aging Sci. Pharmacol., Kyushu Univ., 2OBT Research Center, Kyushu Univ.,3Shenzhen Key Lab.
Immuno. Neurol. Dis., Shenzhen Inst. Adv. Tech., Acad. Sci. CHN,4Dept. Dept. Oral Maxillofac. Surg. Kyushu
Univ., 5Dept. Geriatric Dentistry and Perioperative Medicine in Dentistry, Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-B-O05-4 一般演題（口頭）Characterization of aripiprazol on motor symptoms in mouse models of
Parkinson‘s disease
Jiro Kasahara, Mihiro Sakashita, Hiten Iwamoto, Masatoshi Ogawa
Dept. Neurobiol. Theapeu., Grad. Sch. Biomed. Sci., Tokushima Univ.

Copyright © The Japanese Pharmacological Society2-B-O05-5 一般演題（口頭）Role of the hypothalamus and the nucleus accumbens in regulation of
glucose metabolism by dopamine D2 receptors
Hiroko Ikeda, Naomi Yonemochi
Dept Pathophysiol Therap, Hoshi Univ Sch Pharm Pharmaceut Sci

Copyright © The Japanese Pharmacological Society2-B-O06-1 一般演題（口頭）Effects of physical reaction on emotional state: development of optogeneticbased cardiac pacing in awake freely moving mice
Yamashita Akira1, Jun Kaminosono2, Yuki Kambe3, Satoshi Imai1, Akihide Tanimoto4,
Tomoyuki Kuwaki2
1

Dept. Medical Neuropharmacol., Wakayama Med. Univ., Sch. Pharmaceut. Sci., 2Dept. Physiol1., Kagoshima
Univ., Grad. Sch. Med. & Dent. Sci., 3Dept. Pharmacol. Kagoshima Univ., Grad. Sch. Med. & Dent. Sci., 4Dept.
Pathol. Kagoshima Univ., Grad. Sch. Med. & Dent. Sci.

Copyright © The Japanese Pharmacological Society2-B-O06-2 一般演題（口頭）Real-time intraocular antiglaucoma drugs measurement in porcine eyes
using boron-doped diamond microelectrodes.
Genki Ogata1, Mao Yoneda1, Risa Ogawa1, Ai Hanawa1, Kai Asai1, Reiko Yamagishi2,
Megumi Honjo2, Makoto Aihara2, Yasuaki Einaga11Dept. of Chem., Fac. of Sc.i and Tech., Keio Univ., 2Dept. of Ophthalmol., Univ. of Tokyo Sch. Med.

Copyright © The Japanese Pharmacological Society2-B-O06-3 一般演題（口頭）
Wnt5a, produced by physiological mechanical stimulation on the periodontal
ligament, regulates neuronal differentiation in the trigeminal mesencephalicnucleus
Kaori Takahashi1, Takashi Yoshida1,2, Takashi Nakamura1, Minoru Wakamori1
1Div. Mol. Pharmacol. Cell Biophys., Grad Sch. Dent., Tohoku Univ.,2Div. Pharmacol. Fac. Pharmaceut. Sci,
Teikyo Heisei Univ.

Copyright © The Japanese Pharmacological Society2-B-O06-4 一般演題（口頭）
Administration of bisphosphonates adversely affect femoral heads in mild
type hypophosphatasia model mice
Aki Takahashi1, Kengo Hirai2, Satoshi Ishiduka1, Norio Kasahara3, Satoru Matsunaga4,
Shinichi Abe4, Seikou Shintani2, Masataka Kasahara1
1Dept. Pharmacol. Tokyo Dent. Coll., 2Dept. Pediatric Dent. Tokyo Dent. Coll., 3Dept. Histology and Dept. Biol.
Tokyo Dent. Coll., 4Dept. Anatomy. Tokyo Dent. Coll.

Copyright © The Japanese Pharmacological Society2-B-O06-5 一般演題（口頭）
Antioxidative activity of a novel antioxidant “Substance X” as a direct free
radical scavenger
Tokumaru Osamu1, Akihiro Higuchi2, Takayuki Kawashima3, Kazue Ogata1, Kazuhiro Ueno3,
Shinji Miyamoto3
1

Dept. Physiol., Fac. Welfare Health Sci., Oita Univ., 2Front. Sci. Soc. Co-creat. Init, Kanazawa Univ., 3Dept.
Cardiovasc. Surg., Oita Univ. Fac. Med.

Copyright © The Japanese Pharmacological Society2-B-O07-1 一般演題（口頭）
Establishment of an Age-Related Hearing Loss in vitro Model Using Mouse
Cochlear Cell Line HEI-OC1 Cells and Evaluation System for Autophagy
pathway.
Iwai Yoshito, Oguro Yuji, Yasuda Shuta, Ueno Takafumi, Yoshida Shohei, Furuya Yuriko,
Yamamoto Keiji
Nagahama Institute for biochemical science, Oriental Yeast Co., ltd.

Copyright © The Japanese Pharmacological Society2-B-O07-2 一般演題（口頭）Dispensable role of Rac1 and Rac3 after cochlear hair cell specification
Hiroaki Mohri1,2,3, Takashi Nakamura1,2, Hirofumi Sakaguchi2, Yuzuru Ninoyu1, Naoaki Saito1,
Takehiko Ueyama1
1Lab. of Mol. Pharmacol., Biosignal Research Center, Kobe Univ.,2Dept. of Otolaryngology-Head and Neck
Surgery, Kyoto Prefectural Univ. of Med., 3Dept. of Otolaryngology-Head and Neck Surgery, Red Cross Kyoto
Daiichi Hosp.

Copyright © The Japanese Pharmacological Society2-B-O07-3 一般演題（口頭）GABAergic elimination in the ventral hippocampus induces anhedonia.
Takashi Iwai, Satomi Yoshikawa, Ikumi Takagi, Ayaka Kobayashi, Misa Oyama, Shun Watanabe
Mitsuo Tanabe
Lab. Pharmacol. Sch. Pharm., Kitasato Univ.

Copyright © The Japanese Pharmacological Society2-B-O07-4 一般演題（口頭）Mice lacking GPR143, the receptor for L-DOPA, manifest enhanced sucrose
preference, impaired prepulse inhibition, greater aggression andexacerbated depressive-like behavior
Yoshio Goshima, Hiromi Okatsu, Daiki Masukawa
Dept Mol Pharmacol & Neurobiology, Yokohama City Univ

Copyright © The Japanese Pharmacological Society2-B-O07-5 一般演題（口頭）An astrocyte-derived excitatory molecule in neurological disorders
Eiji Shigetomi1,2, Hideaki Suzuki1,2, Yukiho Hirayama1, Fumikazu Sano1,2,3, Kohei Yoshihara4,
Keisuke Koga4,5, Toru Tateoka6, Hideyuki Yoshioka6, Youichi Shinozaki1,2, Hiroyuki Kinouchi6,
Kenji Tanaka7, Haruhiko Bito8, Makoto Tsuda4,9, Schuichi Koizumi1,2
1

Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2Yamanashi GLIA center, Interdiscipl Grad
Sch Med, Univ Yamanashi, 3Dept Pediatr, Interdiscipl Grad Sch Med, Univ Yamanashi,4Dept Mol and System
Pharmacol, Grad Sch Pharm Sci, Kyushu Univ, 5Dept Mol and System Pharmacol, Grad Sch Pharm Sci, Kyushu
Univ, 6Dept Neurosurg, Interdiscipl Grad Sch Med, Univ Yamanashi, 7Div Brain Sci, Inst Adv Med Res, Keio Univ
Sch Med, 8Dept Neurochem, Grad Sch Med, Univ Tokyo, 9Dept Life Innov, Grad Sch Pharm Sci, Kyushu Univ

Copyright © The Japanese Pharmacological Society2-B-O08-1 一般演題（口頭）A novel molecular mechanism of apoptosis resistance regulated by S1PaPKC signaling
Taketoshi Kajimoto1,2, Alisha D. Caliman2, Irene S. Tobias2, Taro Okada1, Caila A. Pilo2, AnAngela Van2, J. Andrew McCammon2, Shun-ichi Nakamura1, Alexandra C. Newton2
1

Dept. Biochem. Mol. Biol., Kobe Univ., 2Dept. Pharmacol., UC San Diego

Copyright © The Japanese Pharmacological Society2-B-O08-2

一般演題（口頭）

2+

In vivo Ca imaging analysis of pancreatic β-cells and liver hepatocytes
2+using transgenic mouse lines expressing ratiometric Ca sensor protein
Kazunori Kanemaru1, Isamu Taiko1, Kai Chen1, Yuki Motegi1, Yuichi Hiraoka2,3, Toshio Miki1,
Masamitsu Iino1
1

Dept. Physiol., Nihon Univ. Sch. Med., 2Dept. Mol. Neurosci., MRI, TMDU, 3Lab. Genome Edit. Biomed. Res.,
MRI, TMDU

Copyright © The Japanese Pharmacological Society2-B-O08-3 一般演題（口頭）Sex differences in podocytes and glomerular parietal epithelial cells in aging
mice kidney.
Mariko Kamata1, Kanako Hosono1, Kou Hatanaka1, Yoshiya Ito1, Stuart J. Shankland2,
Hideki Amano1
1

Dept. Pharmacology. Kitasato Univ., 2Dept. Nephrology. University of Washington

Copyright © The Japanese Pharmacological Society2-B-O08-4 一般演題（口頭）Suppression of autophagy contributes to enhanced necroptosis signaling indiabetic kidney after ischemia-reperfusion
Kuno Atsushi, Reo Takahashi, Yukika Saga, Yuki Tatekoshi, Ryusuke Hosoda
Department of Pharmacology, Sapporo Medical University School of Medicine

Copyright © The Japanese Pharmacological Society2-B-O08-5 一般演題（口頭）Mouse model of colitis increases tissue sodium and water content but
decreases blood pressure
Kento Kitada, Kumar Kundo, Asadur Rahman, Akira Nishiyama
Department of Pharmacology, Kagawa University

Copyright © The Japanese Pharmacological Society3-B-O09-1 一般演題（口頭）LRRK2 is involved in neutrophil chemotaxis and LRRK2 kinase inhibitor MLi-2 causes increased chemotactic activity
Yuichi Mazaki1, Haruka Handa2, Yoshizuki Fumoto2
1

Dept. Cell. Pharmcol., Grad. Sch. Med., Hokkaido Univ., 2Dept. Mol. Biol., Grad. Sch. Med., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-B-O09-2 一般演題（口頭）Effect of N-nonanoyl tryptamine on itch in mice with surfactant-induced
eczematoid dermatitis
Tsugunobu Andoh1, Emiri Nishida1, Masanori Somei2, Yasushi Kuraishi3
1

Dept. Pharmacol. Pathophysiol., College Pharm., Kinjo Gakuin Univ., 2SOMEIYAKKO Kenkyusho, 3URA,
Wakayama Med. Univ.

Copyright © The Japanese Pharmacological Society3-B-O09-3 一般演題（口頭）Suppression of itch sensation by IL-27
Daiji Sakata1, Yusuke Nomoto2, Masahiro Yamamoto3, Chisa Nakashima4, Kenji Kabashima4,
Hiroki Yoshida5, Takuro Kanekura2, Hiromitsu Hara1
1

Laboratory of Immunology, Department of Infection and Immunity, Graduate School of Medical and Dental
Sciences, Kagoshima University, 2Department of Dermatology, Faculty of Medicine, Kagoshima University.,3
Research Institute for Microbial Diseases, Osaka University, 4Department of Dermatology, Graduate School of
Medicine and Faculty of Medicine, Kyoto University., 5Biomolecular Sciences, Medicine, Faculty of Medicine, Saga
University

Copyright © The Japanese Pharmacological Society3-B-O09-4 一般演題（口頭）Analgesic action of oclacitinib on postoperative pain in mice
Satoru Horie1, Syunsuke Araki1, Mao Kaneki2, Manami Imamura1, Tomoki Fukuyama2,
Yosihito Shimazu3, Shinichiro Nakamura1, Atsushi Tsukamoto1
1

Dept.Lab.Anim.Sci., 2Lab.Vet. Pharmacol., 3Lab.Food and Physiological Sci.

Copyright © The Japanese Pharmacological Society3-B-O09-5 一般演題（口頭）“Inhibitory” Cannabinoid CB2 receptors have “Excitatory” role to high-fat
diet evoked systemic inflammatory response
Chihiro Nozaki1, Haruka Hosoki2, Andreas Zimmer3
1

Global Center for Science and Engineering, Major in Bioscience, Waseda University, 2Department of Advanced
Science and Engineering, Waseda University, 3Institute of Molecular Psychiatry, University of Bonn

Copyright © The Japanese Pharmacological Society3-B-O10-1 一般演題（口頭）
Choroid plexus epiplexus macrophage derive from parenchymal microglia
Bijay Parajuli1,2, Eiji Shigetomi1,2, Schuichi Koizumi1,2
1

1Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine , University of Yamanashi,
GLIA Center, University of Yamanashi

2

Copyright © The Japanese Pharmacological Society3-B-O10-2 一般演題（口頭）Priming effect of TF inducers on synergistic TF expression, activation of theextrinsic coagulation cascade and intra-cellular gap formation of humanvascular endothelial cells
Takuma Kunieda1, Yuhki Yanase1, Daiki Matsubara2, Shunsuke Takahagi2, Koichiro Ozawa1,
Michihiro Hide2,3
1

Hiroshima Univ., 2Hiroshima Univ., 3Hiroshima Citizens Hosp.

Copyright © The Japanese Pharmacological Society3-B-O10-3 一般演題（口頭）Modulation of STING signaling by advanced glycation end products dependon types and concentration of carbonyl compound
Takashi Nishinaka1, Omer Faruk Hatipoglu1, Hidenori Wake1, Masahiro Watanabe2,
Takao Toyomura2, Shuji Mori2, Masahiro Nishibori3, Hideo Takahashi11Dept. Pharmacol., Facul. Med., Kindai Univ., 2Dept. Pharmcol., Sch. Pharmacy, Shujitsu Univ., 3Dept. Transl. Res.
Drug Dev., Facul. Med. Dent. Pharm. Sci., Okayama Univ.

Copyright © The Japanese Pharmacological Society3-B-O10-4

一般演題（口頭）Kengo Tomita1, Chiharu Ohira2, Himeno Saito2, Tomoe Kurita2, Masaki Nagane2,
Tomoki Fukuyama2
1

Inst. Tech., Shimizu Corp., 2Lab. of Pharmacol., Sch. of Vet. Med., Azabu Univ., 3Lab. of Biochem., Sch. of Vet.
Med., Azabu Univ.

Copyright © The Japanese Pharmacological Society3-B-O10-5 一般演題（口頭）Prolonged oxazolone-induced pruritic dermatitis in mice with atopic dry skin
Masanori Fujii1, Sota Oiso1, Takeshi Nabe2, Satoshi Tanaka1
1

Lab. Pharmacol., Div. Pharmaceut. Sci., Kyoto Pharmaceut. Univ., 2Lab. Immunopharmacol., Fac. Pharmaceut.
Sci., Setsunan Univ.

Copyright © The Japanese Pharmacological Society3-B-O11-1 一般演題（口頭）Integrin-inactivating peptide FNIII14 suppresses MUC5AC secretion in
airway goblet cells.
Kawakita Shosuke, Kazuhito Murakami, Fumio Fukai, Yoichiro Isohama
Lab. of appl. pharmacol., Fac. of Pham. of Sci., Tokyo Univ. of Sci.

Copyright © The Japanese Pharmacological Society3-B-O11-2 一般演題（口頭）The regulatory effects of sleep-related neuropeptide on the upper airway
muscle contraction
Yoko Irukayama1, Hisayo Jin2, Saki Taiji2, Tsuyoshi Nemoto3,7, Jundal Kim4, Tomoya Hamamura5,
Yunosuke Ogata5, Tomoko Misawa6, Takashi Kanbayashi7, Takashi Nishino2, Shiroh Isono2,
Yositoshi Kasuya8, Koichiro Tatsumi6
1Med. Mycol. Res. Center, Chiba Univ., 2Dept. of Anesthesiology Grad. Sch. of Med. Chiba Univ., 3Dept. of Med.
Educ. Grad. Sch. of Med. Chiba Univ., 4Inst. of Natural. Med. Toyama Univ., 5Dept. of Med. Sch. of Med. Chiba
Univ., 6Dept. of Respirology. Grad. Sch. of Med. Chiba Univ., 7Univ. of Tsukuba, IIIS, 8Dept. of Biomed. Sci.Grad.
Sch. of Med. Chiba Univ.

Copyright © The Japanese Pharmacological Society3-B-O11-3 一般演題（口頭）Search for novel therapeutic interventions against lung fibrosis using
patient-derived lung myofibroblasts
Motoya Hiraki1,2, Hidemi Ogawa1,3, Tomoko Misawa3, Hiroyuki Nakamura2, Koichiro Tatsumi3,
Takuji Suzuki3, Jundal Kim4, Yoshitoshi Kasuya1
1Dept. Biomed. Sci., Grad. Sch. Med., Chiba Univ., 2Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Chiba
Univ., 3Dept. Respirology, Grad. Sch. Med., Chiba Univ., 4Dept. Res. and Development, Div. CBR, Inst. Natl. Med.,
Toyama Univ.

Copyright © The Japanese Pharmacological Society3-B-O11-4 一般演題（口頭）
Ferroptosis exacerbates airway inflammation in a mouse model of papaininduced asthma
Genki Kimura, Ai Tagami, Rina Fukui, Masaki Yaita, Tomohiro Miyasaka
Lab. Physiol. & Anat., Nihon Univ. Sch. Pharmacy

Copyright © The Japanese Pharmacological Society3-B-O11-5 一般演題（口頭）
Involvement of VEGFR1 signaling in LPS-induced lung injury in mice
Osada Mayuko1, Atsushi Yamashita1, Mina Tanabe1, Seishiroh Akinaga1, Mariko Kamata1,
Kanako Hosono1, Koh Hatanaka1, Yoshiya Ito1, Masabumi Shibuya2, Masataka Majima3,
Hideki Amano1
1

Kitasato Univ. Pharmacol., 2Inst. Physiol. & Med. Jobu Univ., 3Kanagawa Inst. of Technology

Copyright © The Japanese Pharmacological Society3-B-O12-1 一般演題（口頭）Triterpenoid saponin from Panax ginseng inhibits the toxin production andincreases the sensitivity to antibiotics in methicillinresistant Staphylococcus aureus
Mayuko Oka1, Sakura Tsutamoto1, Krisna Nugraha Dendi2, Keiichi Samukawa3, Hiroshi Iwao1,
Yasuhiko Horiguchi2
1

Kyoto Prefectural Univ., 2RIMD, Osaka Univ., 3Osaka Metropolitan Univ.

Copyright © The Japanese Pharmacological Society3-B-O12-2 一般演題（口頭）Goreisan modulates forskolin-induced aquaporin 2 localization change via
the calcium-sensing receptor.
Keisuke Ogura, Naoki Fujitsuka, Youhei Tokita
Tsumura Kampo Research Laboratories

Copyright © The Japanese Pharmacological Society3-B-O12-3 一般演題（口頭）Analysis of effect on Doxorubicin-induced cardiotoxicity by Kampo medicine
Funamoto Masafumi1, Amiho Muramatsu2, Miyako Ueno2, Masaki Imanishi2, Koichiro Tsuchiya2,
Yasumasa Ikeda1
1

Dept. of Pharmaco., Grad. Sch. of Biomed. Sci., Tokushima Univ., 2Dept. of Med. Pharmaco., Grad. Sch. of
Biomed. Sci., Tokushima Univ.

Copyright © The Japanese Pharmacological Society3-B-O12-4 一般演題（口頭）Endothelium-independent vasorelaxant effects of sudachitin anddemethoxysudachitin, polymethoxyflavone from the peel of Citrus sudachi
on isolated rat aorta
Kazuo Noguchi, Chinami Ueda, Mako Watanabe, Misaki Goma, Saki Umeda, Sawako Tabira,Koto Furuyama, Mirai Taniguchi, Aino Nagai, Haruna Kanae
Lab. of Fac. Food Sci., Dep. of Health & Bio-Pharmaceut. Sci., Sch. of Pharm. & Pharmaceut. Sci., Mukogawa
Women’s Univ.

Copyright © The Japanese Pharmacological Society3-B-O12-5 一般演題（口頭）Goreisan prevents renal fibrosis in a mouse model of folic acid-induced
chronic kidney disease
Yasumasa Ikeda1, Aoi Suenega1,3, Yasuyuki Seto1,3, Masafumi Funamoto1, Masaki Imanishi2,
Koichiro Tsuchiya2
1

Dept. Pharmacol. Tokushima Univ. Grad. Sch. Med., 2Dept. Med. Pharmacol. Tokushima Univ. Grad. Sch. Med.,
3
Student Lab. Tokushima Univ. Fac.Med

Copyright © The Japanese Pharmacological Society3-B-O13-1 一般演題（口頭）
Oral administration of linoleic acid immediately before glucose load slowed
the elevation of postprandial glucose levels via GPR120 pathway
Yuta Yamamoto1, Katsuya Narumi2, Naoko Yamagishi1, Toshio Nishi1, Takao Ito1, Ken Iseki2,
Masaki Kobayashi2, Yoshimitsu Kanai1
1Dept. Anat. Cell Biol. Wakayama Med. Univ., 2Lab. clinical pharmaceut. & therap., Div. Pharmasciences, Fac.
Pharmaceut. Sci., Hokkaido Univ.

Copyright © The Japanese Pharmacological Society3-B-O13-2 一般演題（口頭）Hepatocyte-derived EVs Might Contribute to the Inflammation ofMacrophages in the Liver, and Adipose Tissue.
Yoshinori Ichihara1,2, Yohei Sanada2, Takahisa Nakamura2, Takeshi Imamura1
1Div. Pharmacol., Faculty of Med., Tottori Univ.,2Div. of Endocrinology, Cincinnati Children's Hospital Medical
CenterCopyright © The Japanese Pharmacological Society3-B-O13-3 一般演題（口頭）Thyroid hormone insufficiency in neonatal period causes the circadianrhythm alteration as well as the Sox2 upregulation in the developing
suprachiasmatic nucleus in mice
Kana Ohuchi, Kanae Satoh, Takahiro Moriya
Dept. Pharmacol. Sch., Pharmaceut. Sci., Ohu Univ.

Copyright © The Japanese Pharmacological Society3-B-O13-4 一般演題（口頭）Possible roles of mitochondrial protein p13 in the control of white adipose
tissue amount
Masafumi Noguchi1, Satomi Hara2, Keiko Iwata1, Hitoshi Hashimoto2,3,4,5, Norihito Shintani1,21Sch. Pharmaceut. Sci., Wakayama Med. Univ., 2Grad. Ach. Pharmaceut. Sci., Osaka Univ., 3United Grad. Sch.
Child Dev., Osaka Univ., 4Div. Biosci., Inst. Datability Sci., Osaka Univ., 5Inst. Open Transdiscip. Res. Initiatives,
Osaka Univ.

Copyright © The Japanese Pharmacological Society3-B-O13-5 一般演題（口頭）Functional Analysis of Sphingosine Kinase 1 in Brown Adipose Tissue
Morishige Jun-ichi1, Kazuaki Yoshioka2, Naoto Nagata1, Tamotsu Takana3, Yoh Takuwa2,
Hitoshi Ando1
1

Dept. Cell. Mol. Func. Anal. Kanazawa Univ., 2Dept. Physiol. Kanazawa Univ., 3Grad. School of Tech., Industrial
and Soc. Sci., Tokushima Univ.

Copyright © The Japanese Pharmacological Society3-B-O14-1 一般演題（口頭）Overcoming multidrug resistance in cancer by targeting Hsp70-interacting
proteins
Masako Tanaka1, Masayuki Shiota2, Susumu Imaoka1
1

Dept. Biomed. Chem., Sch. Biol. Environ. Sci., Kwansei Gakuin Univ., 2Dept. Mol. Biol. Med., Grad. Sch. Med.,
Osaka Metropolitan Univ.

Copyright © The Japanese Pharmacological Society3-B-O14-2 一般演題（口頭）Carbidopa and benserazide that inhibit cystathionine-β-synthase, an H2Sforming enzyme, suppress the viability of both bortezomib-sensitive and resistant multiple myeloma cells
Fumiko Sekiguchi1, Haruka Moriguchi1, Yukiho Fukushima1, Yuriko Iba1, Maho Tsubota1,
Shiori Hiramoto1, Takuya Okada2, Naoki Toyooka2, Hirokazu Tanaka3, Takashi Ashida3,
Itaru Matsumura3, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Grad. Sch. Sci. Technol., Univ. Toyama,3Div.
Hematol. Rheumatol., Kindai Univ. Fac. Med.

Copyright © The Japanese Pharmacological Society3-B-O14-3 一般演題（口頭）SN38-BGLs: Novel hydrophilic camptothecin derivatives suppress tumor
growth without diarrhea in murine xenograft model.
Licht Miyamoto1,2, Yuki Tsuchihashi2, Shinji Abe3, Toshihiro Izumi3, Aya Hatano2,
Masaki Imanishi2,4, Yasumasa Ikeda4, Koichiro Tsuchiya2
1

Pharmacol. & Food Sci., Dept. Nutr. & Life Sci., Fac. Health & Med. Sci., Kanagawa Inst. of Technology,2Dept. ofMed. Pharmacol. Inst. of Biomed. Sci., Grad. Sch. of Tokushima Univ., 3Dept. of Clin. Pharm. Pract. Pedagogy,
Inst. of Biomed. Sci., Grad. Sch. of Tokushima Univ., 4Dept. of Pharmacol. Inst. of Biomed. Sci., Grad. Sch. ofTokushima Univ.

Copyright © The Japanese Pharmacological Society3-B-O14-4 一般演題（口頭）Novel pharmacotherapy targeting NF-κB signal for triple-negative breast
cancer patients with loss of CYLD expression
Hitomi Arakaki1, Akari Kuwano1, Chika Hirai1, Chica Saigo1, Ayumi Kanemaru1,
Mitsuhiro Hayashi3, Hideyuki Saito2, Yuki Narita2, Hirofumi Jono2
1

Dept. of Clin. Pharmaceut. Sci., Grad. Sch. of Pharmaceut. Sci, Kumamoto Univ., Kumamoto, Japan., 2Dept. of
Pharm., Kumamoto Univ. Hosp., Kumamoto, Japan., 3Dept. of Breast and Endocrine Surgery, Grad. Sch. of Med.
Sci., Kumamoto Univ., Kumamoto, Japan

Copyright © The Japanese Pharmacological Society3-B-O14-5 一般演題（口頭）Clioquinol affects the mitochondrial respiratory chain complex IV
Masato Katsuyama
Radioisotope Ctr., Kyoto Pref. Univ. Med.

Copyright © The Japanese Pharmacological Society3-B-O15-1 一般演題（口頭）Hypoxia increases intracellular BH4 levels under inflammatory cytokinestimulated human umbilical vein endothelial cell (HUVEC).
Kazuhisa Ikemoto, Taiki Kano, Yui Suganuma, Chiho Ichinose, Kazunao Kondo
Department of Pharmacology, Fujita Health University School of Medicine

Copyright © The Japanese Pharmacological Society3-B-O15-2 一般演題（口頭）Inhibitory effects of corosolic acid on cell proliferation in pulmonary arterial
hypertension
Aya Yamamura, Hossain Alamgir, Rie Takahashi, Motohiko Sato
Dept. Physiol., Aichi Med. Univ.

Copyright © The Japanese Pharmacological Society3-B-O15-3 一般演題（口頭）YAP-induced upregulation of GLUT1 promotes adaptive cardiac hypertrophyduring acute pressure overload
Toshihide Kashihara1, Tsutomu Nakahara1, Junichi Sadoshima2
1

Kitasato Univ. Sch. of Pharmceut. Sci. Dept. of Mol. Pharmacol., 2Rutgers New Jersey Med. Sch. Cardiovasc. Res.
Inst. Dept. of Cell Bio. and Mol. Med.

Copyright © The Japanese Pharmacological Society3-B-O15-4 一般演題（口頭）Effect of CaMKII on Atrial Fibrillation in Early Stage of High-Fat Diet-induced
Obesity
Tatsuya Sawano1, Junichiro Miake1, Takuya Tomomori2, Akihiro Okamura2, Priyono Agung1,
Yoshinori Ichihara1, Keiko Nagata1, Takeshi Imamura1
1

Division of Pharmacology, Faculty of Medicine, Tottori University, 2Department of Cardiovascular Medicine,
Endocrinology and Metabolism, Faculty of Medicine, Tottori University

Copyright © The Japanese Pharmacological Society3-B-O15-5 一般演題（口頭）The up-regulation of Neuregulin-1-ErbB signaling contributes to preventing
the onset of systolic dysfunction in diabetic cardiomyopathy
Yoshinori Mikami, Fumiki Iwase, Daisuke Ohshima, Taichiro Tomida, Satomi Adachi-Akahane
Dept. Physiol., Fac. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-B-O16-1 一般演題（口頭）Organ Specificity of Mesenchymal Stromal Cells Underlie Homeostatic
Tissue Maintenance of Multicellular Organisms.
Kurosawa Tamaki1,7, Noriyuki Kaji2, Momo Goto1, Takashi Chaen1, Taiki Mihara1,
Madoka Uezumi3, Yuki Yoshimoto4, Keitaro Minato5, Eiji Hase6, Yumiko Oishi7, Hiroyuki Koike7,
Ichiro Manabe8, Akiyoshi Uezumi3, Masatoshi Hori1
1

Dept. of Vet. Pharmacol. Grad. Sch. of Agr. and Life Sci., Univ. of Tokyo,2Vet. Pharmacol., Sch. of Vet. Med., Azabu
Univ., 3Div. of Cell Heterogeneity, Med. Inst. of Bioregulation, Kyushu Univ.,4Sec. of Mol. Craniofac. Embryol.
Grad. Sch. of Tokyo Med and Dent. Univ., 5Dept. of Regen. and Transplant Med., Div. of Orthopedic Surg., Grad.
Sch. of Med. and Dent. Sci., Niigata Univ., 6Div. of Interdiscip. Researches for Med. and Photonics, Inst. of PostLED Ph otonics, Tokushima Univ., 7Dept. of Med. Biochem., Grad. Sch. of Med., Tokyo Med. and Dent. Univ.,
8
Dept. of Systems Med., Grad. Sch. of Med., Chiba Univ.

Copyright © The Japanese Pharmacological Society3-B-O16-2 一般演題（口頭）Investigation of mucosal absorbing water of the rat bladder using “insideout” samples
Naoki Aizawa, Tomoe Fujita
Dept. Pharmacol. Toxicol., Dokkyo Medical Univ.

Copyright © The Japanese Pharmacological Society3-B-O16-3 一般演題（口頭）Novel CACNA1S mutations for malignant hyperthermia enhance2+depolarization-induced Ca releaseTakashi Murayama1, Takuro Numaga-Tomita2, Hirotsugu Miyoshi3, Keiko Mukaida3,
Taichiro Tomida4, Nagomi Kurebayashi1, Takuya Kobayashi1, Tsutomu Nakada2, Satomi AdachiAkahane4, Yasuo M. Tsutsumi3, Mitsuhiko Yamada2, Takashi Sakurai11

Dept Pharmacol, Juntendo Univ, 2Dept Mol Pharmacol, Shinshu Univ, 3Dept Anesthesiol Crit Care, Hiroshima
Univ, 4Dept Physiol, Fac Med, Toho Univ

Copyright © The Japanese Pharmacological Society3-B-O16-4 一般演題（口頭）Morphological study of actin remodeling with Spingosylphosphorylcholine
in smooth muscle cell
Hideyuki Tanaka
Dept, Anatomy, Teikyo Univ, sch,Med

Copyright © The Japanese Pharmacological Society3-B-O16-5 一般演題（口頭）Comparative study of effects of NAd and PACAP on contractile and electricalactivities in human colon.
Yoshihiko Kito1, Masaaki Kurahashi21Dept. Pharmacol. Fac. Med. Saga Univ., 2Dept. Intern. Med. Div. Gastroenterol. Hepatol. Univ. Iowa

Copyright © The Japanese Pharmacological Society3-B-O17-1 一般演題（口頭）Anticancer drug nilotinib-induced electrical, calcium, and mechanicalalternans in human iPS cell-derived cardiomyocyte sheets
Hiroko Izumi-Nakaseko1, Ryuichi Kambayashi1, Yuko Sekino2,3, Yasunari Kanda4,
Atsushi Sugiyama1
1

Dept. Pharmacol., Fac. Med., Toho Univ, 2Grad. Sch. Agricultural and Life Sci., Univ. Tokyo, 3Inst. Drug Discovery
Innovation, 4Div. Pharmacol., NIHS

Copyright © The Japanese Pharmacological Society3-B-O17-2 一般演題（口頭）Analysis of cardiohemodynamic and electrophysiological effects ofmorphine using the halothane-anesthetized dogs
Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Atsushi Sugiyama
Dept. Pharmacol., Faculty. Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-B-O17-3 一般演題（口頭）Effect of medetomidine, an anesthetic for animals, and dexmedetomidine, asedative for humans, on thrombus formation.
Taiki Kano1, Yui Suganuma1, Kazuhisa Ikemoto1, Chiho Ichinose1, Toshiaki Mochizuki2,
Kazunao Kondo1
1

Dept. Pharmacol., Sch. Med., Fujita Health Univ., 2Anesthesiology and Resuscitology, Fujita Health Univ. OkazakiMed. Ctr.

Copyright © The Japanese Pharmacological Society3-B-O17-4 一般演題（口頭）Characterization of the cardiac safety pharmacological profile of antiinfluenza drug peramivir using the isoflurane-anesthetized dog
Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Atsushi Sugiyama
Dept. Pharmacol., Faculty Med., Toho Univ.

Copyright © The Japanese Pharmacological Society3-B-O17-5 一般演題（口頭）
Identification of a novel gene that regulates proliferation and lipid
metabolism in lymphatic endothelial cells
Akira Sugiyama, Xinyi Liu, Tomohiro Shiiya, Yasuhiro Yoshimatsu, Masanori Hirashima
Div. Pharmacol. Grad. Sch. Med. Dent. Sci. Niigata Univ.

Copyright © The Japanese Pharmacological Society3-B-O18-1 一般演題（口頭）Transient receptor potential melastatin 2 is involved in trinitrobenzene
sulfonic acid-induced acute and chronic colitis-associated fibrosis
progression in mice
Nakamoto Tomohiro1, Kejiro Matsumoto1,2, Hiroyuki Yasuda1, Yasuo Mori3, Shinichi Kato1
1

Lab. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2Dept. Pathophysiol., Fac. Pharm. Sci., Doshisha Women’s Coll.,
3
Dept. of Synthetic Chem. and Biological Chem., Grad. Sch. of Eng., Kyoto Univ.

Copyright © The Japanese Pharmacological Society3-B-O18-2 一般演題（口頭）Proteasome inhibitor attenuates the activation of hepatic stellate cell
Atsushi Umemura1, Ayana Fujiwara2, Anna Tanaka2, Kazumi Iwata1, Kikuko Amagase2
1

Kyoto Prefectural University of Medicine, 2Ritsumeikan University

Copyright © The Japanese Pharmacological Society3-B-O18-3 一般演題（口頭）RAMP1 signaling attenuates diet-induced steatotic liver disease in mice
Yoshiya Ito1,2, Kanako Hosono1,2, Tomohiro Betto3, Mina Tanabe2, Atsushi Yamashita2,
Yu Kuroda2, Mariko Kamata1,2, Koh Hatanaka1, Masataka Majima4, Hideki Amano1,2
1

Dept. Pharm., Sch. Med., Kitasato Univ., 2Dept. Mol. Pharm., Grad. Sch. Med., Kitasato Univ., 3Dept.
Gastroenterol, Sch. Med., Kitasato Univ., 4Fac. Health & Med. Sci., Kanagawa Inst. Tech

Copyright © The Japanese Pharmacological Society3-B-O18-4 一般演題（口頭）Sympathetic nerves suppress the activation of resident macrophages in thegastrointestinal muscularis layer via beta adrenergic receptors
Tomo Fukuda, Noriyuki Kaji
Lab.Vet.Pharmacol.,Sch.Vet.Med.,Azabu Univ.

Copyright © The Japanese Pharmacological Society3-B-O18-5 一般演題（口頭）Stratification and prediction of peg-IFN treatment efficacy in chronic
hepatitis B patients
Naotoshi Nakamura1, Kwangsu Kim2, Shingo Iwami1
1interdisciplinary Biology Laboratory, Graduate School of Science, Nagoya University, 2Department of Scientific
Computing, Pukyong National University

Copyright © The Japanese Pharmacological Society3-B-O19-1 一般演題（口頭）The effects of hypoxia-inducible factors on tumor macrophages in the tumor
microenvironment and tumor immunity
Shinji Matsunaga, Ryo Hirakawa, Takujirou Homma, Kentarou Tokudome, Shuhei Tomita
Dept.Pharmacol. Osaka Metro. Univ. Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society3-B-O19-2 一般演題（口頭）Hornerin expressed in endothelial cells implicates in angiogenesis
Takayuki Okamoto1, Yukiko Katsube2, Mai Hattori2, Haruki Usuda1, Junichi Ota2, Tetsuro Nikai2,
Koichiro Wada1
1

Dept. Pharmacol. Shimane Univ., 2Dept. Anesthesiol. Shimane Univ.

Copyright © The Japanese Pharmacological Society3-B-O19-3 一般演題（口頭）Development of anti-CD44 isoform-specific monoclonal antibodies
Suzuki Hiroyuki, Mika Kaneko, Yukinari Kato
Dept. Antibody Drug Development, Tohoku University Grad. Sch. of Med.

Copyright © The Japanese Pharmacological Society3-B-O19-4 一般演題（口頭）Probiotic derived heptelidic acid is cytotoxic in pediatric B-cell acutelymphoblastic leukemia
Konishi Hiroaki1,3, Yuki Murakami2,3, Koji Yamamoto2, Chikage Yamamura2, Noriko Satake3,
Mikihiro Fujiya2
1Asahikawa Med Univ. Dept. of Gastro. Adv. Med. Sci., 2Asahikawa Med Univ. Dept. of Med., 3UC Davis. Dept. ofPed.

Copyright © The Japanese Pharmacological Society3-B-O19-5 一般演題（口頭）Suppression of tumor spheroid formation by matrix metalloproteinase 19(MMP19) in pyruvate dehydrogenase-E1β (PDH-E1β) knockdown (KD) cells
Yukino Kobayashi, Koh Nakayama
Dep. of Pharmacol., Sch. of Med., Asahikawa Med. Univ.

Copyright © The Japanese Pharmacological Society1-B-SS01-1 学生セッション（口頭）Nardilysin is involved in autoimmune hepatitis via T-cells
Shinya Yoshida1,3, Hiroki Satooka2, Kiyoto Nishi1, Mikiko Ohno1, Takako Hirata2, Akira Andoh1,3,Eiichiro Nishi1
1

Dept. of Pharmacol, Shiga Univ. of Med. Sci., 2Dept. of Biol, Shiga Univ. of Med. Sci., 3Dept. of Gas, Shiga Univ. ofMed. Sci.

Copyright © The Japanese Pharmacological Society1-B-SS01-2 学生セッション（口頭）Glutamate treatment abrogates 5-fluorouracil-induced mucoenteritis
Jonan Shizuka1, Shinichi Kato2, Kikuko Amagase1
1

Lab. of Pharmacol. & Pharmacother., Grad. Sch. of Pharmaceut. Sci, Ritsumeikan Univ., 2Dep. of Pharmacol. &Exp. Therap., Kyoto Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society1-B-SS01-3 学生セッション（口頭）Involvement of NRF2 transcription activity in prostaglandin E2-induced
facilitation of the inhibitory effect of caffeine on hepatic stellate cell
activation.
Watanabe Yuta1, Momoka Yamaguchi1, Naoki Dohi1, Akira Ooka1, Shin-ya Saito1,2,Tomohisa Ishikawa1
1

Dept. Pharmacol., Grad. Sch. Integr. Pharmaceut. and Nutritional Sci., Univ. Shizuoka, 2Lab. Drug Discovery andPharmacol., Fac. Veterinary Med., Okayama Univ. Sci

Copyright © The Japanese Pharmacological Society1-B-SS01-4 学生セッション（口頭）Protective role of orphan G protein-coupled receptor GPR35 in thepathogenesis of dextran sulfate sodium-induced colitis in mice
Tokuyama Kouga1, Toma Yagi1, Momoka Bunya1, Saeko Yamamoto1, Hiroyuki Yasuda1,
Michiko Saito2, Shinichi Kato1
1

Lab. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2BioSci. Res., Kyoto Pharm. Univ.

Copyright © The Japanese Pharmacological Society1-B-SS01-5 学生セッション（口頭）Exendin-4 dosing time-dependently affects hepatic circadian clock throughGLP-1 receptors in the central nervous system
Pingping Xu, Jun-ichi Morishige, Zheng Jing, Naoto Nagata, Hitoshi Ando
Dept. Cell. Mol. Funct. Analysis, Kanazawa Univ. Grad. Sch. Med. Sci.

Copyright © The Japanese Pharmacological Society1-B-SS02-1 学生セッション（口頭）Effects of Schisandra chinensis on memory deficit induced by disuse
syndrome
Yusho Ishii1, Chihiro Tohda2
1

Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2Section of Neuromedical
Science, Institute of Natural Medicine, University of Toyama

Copyright © The Japanese Pharmacological Society1-B-SS02-2 学生セッション（口頭）Exploration of key molecules for diosgenin-induced axonal regeneration in
the brain.
Tomoya Nagata, Ximeng Yang, Chihiro Tohda
Institute of Natural Medicine, Section of Neuromedical Science, Univ. of Toyama

Copyright © The Japanese Pharmacological Society1-B-SS02-3 学生セッション（口頭）Exploration of signaling molecules involved in the reversion of activatedhepatic stellate cells utilizing structural modification of small moleculecompounds
Ooka Akira1,3, Momoka Yamaguchi1, Yuzuki Nagasawa2, Kenji Yamashita2, Kaori Inamura2,
Makoto Inai2, Shin-ya Saito4, Yoshitaka Hamashima2, Tomohisa Ishikawa1
1

Lab. Pharmacol., Sch. Pharmaceut. Sci., Univ. Shizuoka, 2Lab. Synth. Org. Chem., Sch. Pharmaceut. Sci., Univ.
Shizuoka, 3JSPS DC1, 4Fac. Vet. Med., Okayama Univ. Sci.

Copyright © The Japanese Pharmacological Society1-B-SS02-4 学生セッション（口頭）Ligilactobacillus animalis isolated from canine intestinal microbiota
significantly inhibits the development of allergic diseases in a mouse model
via direct enhancement of IL-10 production by dendritic cells
Ibuki Yasuda1, Mao Kaneki1, Masaki Nagane2, Shiro Takeda3, Jumpei Uchiyama4,
Tomoki Fukuyama1
1Lab. of Pharmacol., Sch. of Vet. Med., Azabu Univ., 2Lab. of Biochem., Sch. of Vet. Med., Azabu Univ., 3Lab. ofFood Sci., Sch. of Vet. Med., Azabu Univ., 4Dept. of Bacteriol., Grad. Sch. of Med. Dent. & Pharmaceut. Sci.,
Okayama Univ.

Copyright © The Japanese Pharmacological Society1-B-SS02-5 学生セッション（口頭）Preventive effects of orally administered arctigenin on neovascular agerelated macular degeneration
Aimi Shirakawa1, Hiroto Yasuda1, Shinsuke Nakamura1, Yuichi Takajo2, Satoshi Inamasu2,
Satoshi Yomoda2, Shimpei Watanabe2, Masamitsu Shimazawa1
1

Dept. Biofunctional Evaluation., Gifu Pharmaceut. Univ., 2Kracie Holdings, Ltd.

Copyright © The Japanese Pharmacological Society1-B-SS03-1 学生セッション（口頭）Pathophysiological role of the chloride channel ClC3 in pulmonary arterial
hypertension.
Amano Taiki1, Aya Yamamura2, Moe Fujiwara1, Rubii Kondo1, Yoshiaki Suzuki1,
Hisao Yamamura1
1Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Physiol., Aichi Med. Univ.

Copyright © The Japanese Pharmacological Society1-B-SS03-2 学生セッション（口頭）Prolonged exposure to coffee alters serotonin transporter expression in
intestinal epithelial cells via DNA methylation
Satoshi Kikkawa1, Emi Kiyota2, Kana Harada1, Shigeru Tanaka1, Izumi Hide1, Miki Bundo2,
Kazuya Iwamoto2, Norio Sakai1
1Dept. Mol. Pharmacological Neuroscience., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Dept. of Mol. Brain
Sci., Grad. Sch. of Med. Sci., Kumamoto Univ.

Copyright © The Japanese Pharmacological Society1-B-SS03-3 学生セッション（口頭）2+Upregulation of T-type Ca channels expression following phenotype switchof mouse hepatic stellate cells.
Naoki Kawata, Rubii Kondo, Yoshiaki Suzuki, Hisao Yamamura
Dept. Mol. Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ.

Copyright © The Japanese Pharmacological Society1-B-SS03-4 学生セッション（口頭）Characterization of TRPM2 in canine peripheral blood mononuclear cells
Ueda Naoto, Takuya Yamaguchi, Jun Yamazaki
Lab. Vet. Pharmacol., Dept. Vet. Med., Coll. of Biores. Sci., Nihon Univ.

Copyright © The Japanese Pharmacological Society1-B-SS03-5 学生セッション（口頭）Vibrational spectroscopy study of chemical interaction between κ-opioid
receptor (KOR) and ligands having morphinan structure
Ryo Nishikawa1, Kota Katayama1,2, Seiya Iwata1, Ryoji Suno3, Chiyo Suno3, Takuya Kobayashi3,
Hideki Kandori1,2
1

Grad. Sch. of Engineering, Nagoya Inst. of Tech., 2OptoBio Tech. Res. Ctr, Nagoya Inst. of Tech.,3Dept. of Med.,
Kansai Med. Univ.

Copyright © The Japanese Pharmacological Society1-B-SS04-1 学生セッション（口頭）Therapeutic effects of drugs developed for CFTR mutations in Caucasians
on a Japanese Q98R CFTR mutation
Kimijima Rio1, Yuzuki Takahasi1, Noa Nakajima1, Yuuka Saitou1, Kana Kobayasi1, Saki Uematu1,
Hikaru Shoma1, Yoshiro Shoma1, Kanako Nakao1, Hiroshi Nakagawa2, Ritsuko Imai2
1

Div Mol Ther, Grad Sch Pharm, IUHW, Japan, 2Dept Biol Chem, Coll Biosci Biotech, Chubu Univ, Kasugai,
Japan)

Copyright © The Japanese Pharmacological Society1-B-SS04-2 学生セッション（口頭）
Rat TRPV1 and TRPA1 can constitute functional heterotetoramer.
Aya Kondo1,2, Naoki Kitamura2, Ken-ichi OTSUGURO1
1

Lab. of Pharmacol., Dept. of Basic Vet. Sci., Fac. of Vet. Med., Hokkaido Univ.,2Lab. of Vet Physiol., Dept. of Vet.
Med., Fac. of Agr., Tottori Univ.

Copyright © The Japanese Pharmacological Society1-B-SS04-4 学生セッション（口頭）Vinculin-talin pre-complexes flow over mature focal adhesions without
tensionYing Liu1, Sawako Yamashiro1,2, Naoki Watanabe1,2
1Lab. of Single-molecule Cell Biology, Kyoto Univ. Grad. Sch. Of Biostudies, 2Dept. of Pharmacology, Kyoto
University Faculty of Medicine

Copyright © The Japanese Pharmacological Society1-B-SS04-5 学生セッション（口頭）Development of a rapid and universal method to determine GPCR structures
Kojima Asato1, Toshiki Matsui1, Naoya Kobayashi2, Masahiro Fukuda1, Nakamura Seiwa1,
Kouki Kawakami1, Kazuhiro Kobayashi1, Hideaki Kato1
1

Arts and Sci., The Univ. of Tokyo, 2Mater. Sci., NAIST

Copyright © The Japanese Pharmacological Society1-B-SS05-1 学生セッション（口頭）Age-related changes in immune function and pathogenesis in a mousemodel of asthma
Mao Kaneki1, Chiharu Ohira1, Mana Ichikawa1, Yoshiichi Takagi2, Tomoki Fukuyama1
1Lab. of Vet. Pharmacol., Sch. of Vet. Med., Azabu Univ.,2Japan SLC, Inc.

Copyright © The Japanese Pharmacological Society1-B-SS05-2 学生セッション（口頭）TRPV4 protects OVA-induced food allergy in mice via maintaining colonicepithelial barrier functions
Murayama Yuki1, Kenjiro Matsumoto1,2, Hiroyuki Yasuda1, Shinichi Kato1
1

Lab. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2Dept. Pathophysiol., Fac. Pharm. Sci., Doshisha Women’s Coll.

Copyright © The Japanese Pharmacological Society1-B-SS05-3 学生セッション（口頭）Potential of Beta Caryophyllene (BCP) as the treatment for allergic
responses through CB2 receptor activation
Hosoki Haruka1, Chihiro Nozaki2, Toru Asahi1,31

Waseda Univ. Grad. Sch. of Adv. Sci. & Eng.,2Waseda Univ. Global ctr. for Sci. and Eng. Major in Biosci.,3Waseda
Univ. Res. Org. for Nano & Life Innov.

Copyright © The Japanese Pharmacological Society1-B-SS05-4 学生セッション（口頭）Treatment duration-dependent efficiency of quercetin in mast cell
degranulation and transcriptome landscapeMatsuo Mana
Department of Pharmacology, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan

Copyright © The Japanese Pharmacological Society1-B-SS05-5 学生セッション（口頭）Dasatinib suppresses particulate-induced pyroptosis and acute lunginflammation
Yixi Pan1, Naoki Takemura1, Tatsuya Saitoh1,2,3
1

Dept. Bioresp. Reg., Grad. Sch. Pharm. Sci., Osaka Univ., 2Global Ctr., Med. Eng. Inform., Osaka Univ., 3CiDER,
Osaka Univ.

Copyright © The Japanese Pharmacological Society1-B-SS06-1 学生セッション（口頭）The role of germline mitochondrial DNA mutation in macrophages
Katsuki Wakayama1, Chimere Ezuma2, Keith Mcconn2, Masanori Yoshizumi1, Augustine Choi2,
Kiichi Nakahira1,2
1

Nara Medical University, Pharmacology, 2Weill Cornell Medicine

Copyright © The Japanese Pharmacological Society1-B-SS06-2 学生セッション（口頭）Enhancement of wound healing by Atmospheric-Pressure Plasma exposurein a mouse model of thermal injuries
Chiharu Ohira1, Mao Kaneki1, Chizuki Usui1, Masashi Nakamura2, Kenichiro Miyasato2,
Yu Nagahara2, Hideaki Kai2, Eiji Miyamoto2, Tomoki Fukuyama1
1Lab. of Pharmacol., Sch. of Vet. Med., Azabu Univ., 2Sekisui Chemical Co., Ltd.

Copyright © The Japanese Pharmacological Society1-B-SS06-3 学生セッション（口頭）Mitochondrial dysfunction exacerbates inflammatory responses in primarycultured chondrocytes
Hatsune Motonari1, Yuka Tanaka2, Yoki Nakamura1, Kazue Nakashima1, Norimitsu Morioka1
1

Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Sch. Pharmaceu. Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society1-B-SS06-4 学生セッション（口頭）Administration of 5,6-DiHETE attenuated allergic inflammation in murine
conjunctiva.
Shinya Takenouchi1, Tomoka Suzuki1, Nanae Nagata1, Misato Kida1, Takahisa Murata1,2,3
1

Dept. Anim. Radiol. Tokyo Univ., 2Dept. Vet. Pharmacol. Tokyo Univ.,3Dept. Food Anim. Syst. Tokyo Univ.

Copyright © The Japanese Pharmacological Society1-B-SS06-5 学生セッション（口頭）Involvement of chemokine receptor CCR4 in lipopolysaccharide-induced
depressive-like behavior
Ritsuki Sano, Yuta Hara, Moeka Kitagawa, Tatsuma Honzawa, Kazuhiko Matsuo,
Takashi Nakayama
Div. Chemothr., Kindai Univ. Fac. Pharm.

Copyright © The Japanese Pharmacological Society2-B-SS07-1 学生セッション（口頭）KTtp38, a novel pimozide derivative, suppresses T-type calcium channeldependent somatic and visceral pain
Tsukasa Hatakeyama1, Maho Tsubota1, Yuriko Iba1, Yoshihito Kasanami1, Fumiko Sekiguchi1,
Takuya Takuya2, Naoki Toyooka2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Fac. Pharm., Kindai Univ., 2Fac. Engineer., Univ. Toyama

Copyright © The Japanese Pharmacological Society2-B-SS07-2 学生セッション（口頭）Role of HMGB1 and anaphylatoxin C5a in the development of painful
peripheral neuropathy in leptin receptor-deficient db/db mice and high fat
diet-fed type 2 diabetic mice
Kaichi Sakuma1, Haruka Nakano1, Shiori Iwane1, Maho Tsubota1, Fumiko Sekiguchi1,
Yasuko Tomono2, Masahiro Nishibori2, Atsufumi Kawabata1
1

Lab. Pharmacol. Pathophysiol., Pharm., Kindai Univ., 2Dept Transl Res Drug Dev, Okayama Univ Grad Sch Med
Dent Pharmaceut Sci

Copyright © The Japanese Pharmacological Society2-B-SS07-3 学生セッション（口頭）Stress sensitivity in a mouse model of low back pain
Yamaji Yasuhito1, Seiji Kanazawa1, Sena Washizu1, Kazunari Mori1, Oki Hoshino1,
Noriyasu Ota2, Hiroaki Motohashi2, Yoshihiko Minegishi2, Eri Segi(Nishida)11

Dept. of Biol. Sci. and Tech., Tokyo Univ. of Sci,2Biological Science Research, Kao Corporation

Copyright © The Japanese Pharmacological Society2-B-SS07-4 学生セッション（口頭）FROUNT-mediated pain control of Anti-alcoholism drug disulfiram
Kota Matsuura1,2, Yuya Terashima2, Ryoji Fujizuka1,2, Tasuku Hayashi1,2, Arisa Ohta1,
Kosei Nagai1,2, Daisuke Yamada1, Kosho Makino3, Hideyo Takahashi3, Chihiro Nozaki4,
Koji Matsushima2, Akiyoshi Saitoh1
1

Lab Pharmacol, Fac Pharm Sci, Tokyo Univ of Science, 2Research Institute for Biomedical Science, Tokyo Univ of
Science, 3Lab Pharmacol, Fac Lab Medicinal Chemistry Sci, Tokyo Univ of Science, 4Global Center for Science andEngineering, Major in Bioscience, Waseda University

Copyright © The Japanese Pharmacological Society2-B-SS07-5 学生セッション（口頭）Prophylactic repeated administration of Mirogabalin suppressed Vincristineinduced mechanical allodynia
Ueda Yuki1, Masahito Sawahata2, Toshiaki Kume2, Daisuke Uta2
1

Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of
Toyama, 2Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences,
University of Toyama

Copyright © The Japanese Pharmacological Society2-B-SS07-6 学生セッション（口頭）Analysis of antipruritic effects of SSRIs using various atopic dermatitis
model mice
Kosuke Matsuda, Hikaru Ishisaka, Keita Hori, Masahito Sawahata, Toshiaki Kume, Daisuke Uta
Dept. Appl. Pharmacol, Grad. Sch. Med.

Pharmaceut. Sci, Univ. Toyama

Copyright © The Japanese Pharmacological Society2-B-SS07-7 学生セッション（口頭）Establishment of a novel nerve organoid for sequential analyses of morphol
ogical and functional changes underlyingperipheral neuropathy pathogenesis
Ryosuke Ogido1, Madoka Koyanagi2, Akari Moriya1, Mamiko Saigo3, Satoshi Ihida4,
Tomoko Teranishi4, Kazuo Matsubara5, Tomohiro Terada3, Akira Yamashita2, Satoshi Imai2,31

Dept. Clin. Pharmacol. Therap., Fac. Pharmaceut. Sci., Kyoto Univ., 2Dept. Med. Neuropharmacol., Sch.
Pharmaceut. Sci., Wakayama Med. Univ., 3Dept. Clin. Pharmacol. Therap., Kyoto Univ. Hosp., 4New Business
Promo. Div., Panel Semicon Lab., Sharp Corp., 5Sch. Pharmaceut. Sci., Wakayama Med. Univ.

Copyright © The Japanese Pharmacological Society2-B-SS07-8 学生セッション（口頭）Involvement of hippocampal microglial activity in persistent pain in a mousemodel of knee osteoarthritis
Kenta Yamamoto, Youki Nakamura, Kazue Nakashima, Norimitsu Morioka
Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.

Copyright © The Japanese Pharmacological Society2-B-SS08-1 学生セッション（口頭）Microglial regulation of extracellular ATP released by neuronal activity
Suzuki Hideaki1,2, Eiji Shigetomi1,2, Yukiho Hirayama1, Yukari Takahashi3, Kazuhiro Ikenaka4,
Kenji Tanaka5, Fusao Kato3, Haruhiko Bito6, Schuichi Koizumi1,2
1

Dept Neuropharmacol, Interdiscipl Grad Sch Med, Univ Yamanashi, 2Yamanashi GLIA Center, 3Dept Neurosci,
Jikei Univ, 4Div Neurobiol and Bioinfo, NIPS, 5Div Brain Sci, Inst Adv Med Res, Keio Univ Sch Med, 6Dept
Neurochem, Grad Sch Med, Univ Tokyo

Copyright © The Japanese Pharmacological Society2-B-SS08-2 学生セッション（口頭）Role of microglia in dendritic spine changes of dentate gyrus granule cells
following cerebral ischemia.
Okada Momoka1, Shuma Nakazawa1, Hitomi Takahashi2, Natsumi Yamaguchi1, Jin Nakatani1,
Toshinori Sawano1, Hidekazu Tanaka1
1

Lab. Pharmacol., Grad. Sch. Life Sci., Ritsumeikan Univ., 2Lab. Pharmacol., Dept. Biomed Sci., Col. Life sci.,
Ritsumeikan Univ.

Copyright © The Japanese Pharmacological Society2-B-SS08-3 学生セッション（口頭）Proper distribution and proliferation of microglia involves mechanosensitive
channel Piezo1
Ayato Yamasaki1,2, Makoto Tsuda2, Takahiro Masuda1
1Div. Neuroimmunol., Med. Inst. Bioreg., Kyushu Univ.,2Dept. Mol. Syst. Pharmacol., Grad. Sch. Pharm. Sci.,
Kyushu Univ.

Copyright © The Japanese Pharmacological Society2-B-SS08-4 学生セッション（口頭）Expression and function analysis of immune checkpoint molecule LAG-3 inmicroglia
Motoki Ohshima, Yuta Morisaki, Hidemi Misawa
Div. Pharmacol., Fac. Pharmacy, Keio Univ

Copyright © The Japanese Pharmacological Society2-B-SS08-5 学生セッション（口頭）Neuronal activity-regulated interaction between microglia and myelin
Mikami Koki1, Yuji Ikegaya1,2, Ryuta Koyama1,2
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo

Copyright © The Japanese Pharmacological Society2-B-SS09-1 学生セッション（口頭）Social defeat stress enhances the rewarding effects of cocaine through α1A
adrenoceptors in the medial prefrontal cortex of mice
1

2

2

1

2

Murata Haruka , Atsushi Saito , Kazuhei Niitani , Jumpei Nagasaki , Atsuki Otoda ,
2
2
1,2
1,2
1,2
Yusuke Chujo , Junko Yanagida , Naoya Nishitani , Satoshi Deyama , Katsuyuki Kaneda
1Lab. Mol. Pharmacol., Sch. Pharmaceut. Sci., Kanazawa Univ., 2Lab. Mol. Pharmacol., Inst. Med., Pharmaceut.,
Health Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society2-B-SS09-2 学生セッション（口頭）Role of dopaminergic modulation of glutamatergic transmission from themedial prefrontal cortex to the basolateral amygdala in acute social defeat
stress-induced enhancement of cocaine craving
Atsushi Saito1, Hirohito Esaki1, Haruka Murata2, Xiyan Ni1, Yusuke Chujo1, Yuki Hirano1,
Yuno Mukai1, Naoya Nishitani1,2, Satoshi Deyama1,2, Katsuyuki Kaneda1,2
1

Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ., 2Lab. Mol. Pharmacol., Sch.
Pharmaceut. Sci., Kanazawa Univ.

Copyright © The Japanese Pharmacological Society2-B-SS09-3 学生セッション（口頭）Chronic social stress causes long-term structural alterations of neuronal
projections to the medial prefrontal cortex in mice
Yuki Okuda1, Ryota Shinohara1, Hirokazu Sonobe1, Yuzuki Maruyama1, Masahiro Yamaguchi2,
Kei Ito2, Akinori Sato2, Fumitaka Osakada2, Tomoyuki Furuyashiki11Div. of Pharmacol., Grad. Sch. of Medicine, Kobe University, 2Lab. of Cell. Pharmacol., Dept. of Basic Medical
Sci., Grad. Sch. of Pharmaceut. Sci., Nagoya University.

Copyright © The Japanese Pharmacological Society2-B-SS09-4 学生セッション（口頭）Metabolic changes in selective brain regions induced by chronic stress inmice and their involvement in emotional disturbanceOta Kohei1, Hirotaka Nagai1, Wenran Qiu1, Io Horikawa1, Midori Nagai1, Chisato Numa1,
Shuichi Shimma2,3, Tomomi Yamashita4, Taro Kato4, Tomoyuki Furuyashiki1
1

Div Pharmacol, Grad Sch Med, Kobe Univ, 2Dept Biotechnol, Grad Sch Engineering, Osaka Univ, 3Omics
Innovation Res Lab, Osaka Univ Shimadzu, 4Pharmacol Res Unit, Sumitomo Pharma

Copyright © The Japanese Pharmacological Society2-B-SS09-5 学生セッション（口頭）The sucrose intake changes stress-induced behavior via dysfunction ofnoradrenergic nervous system.
Takatoshi Sakata1, Akihiro Mouri1,4, Kazuo Kunisawa1, Masaya Hasegawa1, Takaya Nishikawa1,
Masao Takemura2,5, Hidetoshi Matunami5, Kuniaki Saito2,3,4, Toshitaka Nabeshima3,41

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2Dept. Disease Control & Prevention., Grad.
Sch. Health Sci., Fujita Health Univ., 3Lab. Health & Medical Sci. Innov., Grad. Sch. Health Sci., Fujita Health
Univ., 4NPO. J-DO, 5RECHS

Copyright © The Japanese Pharmacological Society2-B-SS09-6 学生セッション（口頭）The role of 5-HT neurotransmission in the regulation of the motivation forwheel running in mice
Kazuhei Niitani1, Ryoma Nishida2, Naoya Nishitani1,2, Satoshi Deyama1,2, Katsuyuki Kaneda1,2
1

Lab. Mol. Pharmacol., Inst. Med., Pharmaceut., Health Sci., Kanazawa Univ., 2Lab. Mol. Pharmacol., Sch.
Pharmaceut. Sci., Kanazawa Univ

Copyright © The Japanese Pharmacological Society2-B-SS09-7 学生セッション（口頭）Role of the transcription factor CREB in antidepressant effects in the
hippocampus
Yui Sayoko, Yutaka Kanda, Mio Kutsuzawa, Sayoko Suzuki, Eri Segi-Nishida
Dept. of Biol. Sci. and Tech., Tokyo Univ of Sci

Copyright © The Japanese Pharmacological Society2-B-SS09-8 学生セッション（口頭）Identification of the medial prefrontal circuit responsive to the atypicalantipsychotic drug clozapine.
Yumi Hirato1, Kaoru Seiriki1, Shohei Yamada1, Leo Kojima1, Atsushi Kasai1,2,
Takanobu Nakazawa3, Hitoshi Hashimoto1,4,5,6,7
1

Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., Osaka, Japan, 2Drug Innov. Cent., Grad.
Sch. Pharmaceut. Sci., Osaka Univ., Osaka, Japan, 3Dept. Biosci., Fac. Life Sci., Tokyo Univ. Agr., Tokyo, Japan,
4
Mol. Res. Ctr. Child. Ment. Dev., United Grad. Sch. Child Dev., Osaka Univ., Osaka, Japan,5Div. Biosci., Inst.
Datability Sci., Osaka Univ., Osaka, Japan, 6Transdimensional. Life Imaging Div., Inst. for Open Transdisciplinary
Res. Initiatives, Osaka Univ., Osaka, Japan, 7Dept. Mol. Pharmaceut. Sci., Grad. Sch. of Med., Osaka Univ., Osaka,Japan

Copyright © The Japanese Pharmacological Society2-B-SS10-1 学生セッション（口頭）Development of AAV vectors with optimized cell-type specificity and labelingefficiency using cell-type-specific promoters.
Leo Kojima1, Kaoru Seiriki1, Hiroki Rokujo1, Atsushi Kasai1, Takanobu Nakazawa2,
Hitoshi Hashimoto1,3,4,5,6
1

Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., Osaka, Japan, 2Dept. Biosci., Fac. Life
Sci., Tokyo Univ. Agr., Tokyo,3Mol. Res. Ctr. Child. Ment. Dev., United Grad. Sch. Child Dev., Osaka Univ., Osaka,
Japan, 4Div. Biosci., Inst. Datability Sci., Osaka Univ., Osaka, Japan, 5Transdimensional. Life Imaging Div., Inst.
for Open Transdisciplinary Res. Initiatives, Osaka Univ., Osaka, Japan, 6Dept.Mol. Pharmaceut. Sci., Grad. Sch. ofMed., Osaka Univ., Osaka, Japan

Copyright © The Japanese Pharmacological Society2-B-SS10-2 学生セッション（口頭）Axo-axonic cells regulate associative learning.
Nakashima Miki1, Yuji Ikegaya1,2, Shota Morikawa1,3
1

Lab Chem Pharmacol, Grad Sch Pharmaceut Sci, Univ Tokyo, 2Inst AI Beyond, Univ Tokyo, 3Lab Mol
Neurophysiol, Grad Sch Sci, Univ Tokyo

Copyright © The Japanese Pharmacological Society2-B-SS10-3 学生セッション（口頭）Membrane potentials of retrosplenial late spiking neurons are not lockedwith neocortical slow waves
Hiroyuki Mizuno1, Yuji Ikegaya1,2
1Lab. Chem. Pharmacol., Grad. Sch. Pharmaceut. Sci., Univ. Tokyo, 2Inst. AI Beyond, Univ. Tokyo

Copyright © The Japanese Pharmacological Society2-B-SS10-4 学生セッション（口頭）Mechanism of mitochondrial translation inhibition by C9ORF72 dipeptide
repeat proteins.
Rio Yamazaki, Kohsuke Kanekura
Department of Pharmacology, Tokyo Medical University

Copyright © The Japanese Pharmacological Society2-B-SS10-5 学生セッション（口頭）Modulation of astrocyte activation via the NF-κB pathway by sphingomyelin.
Ryo Kadowaki, Takuya Honda, Hiroyuki Nakamura
Lab. Chemical Pharmacol., Grad. Sch. Pharmaceut. Sci., Chiba Univ.

Copyright © The Japanese Pharmacological Society2-B-SS11-1 学生セッション（口頭）15-hydroxyeicosatrienoic acid can be a novel exacerbating lipid mediator fornasal congestion which stimulates PGD2 and PGI2 receptors.
1

1

1

1

1

Noriko Ozaki , Naoaki Sakamoto , Daiki Horikami , Yuri Tachibana , Nanae Nagata ,
2
3
3
4
1,2,5
Koji Kobayashi , Yoshino Arai , Masayoshi Sone , Kazuhiro Hirayama , Takahisa Murata
1

Dept. Animal Radiolody., Grad. Agr. & Life Sciences., Univ. of Tokyo,2Crs. Food and Animal Systemics., Grad.
Agr. & Life Sciences., Univ. of Tokyo,3Sone clinic, 4Dept. Veterinary Public Health., Grad. Agr. & Life Sciences.,
Univ. of Tokyo, 5Dept. Veterinary Pharmacol., Grad. Agr. & Life Sciences., Univ. of Tokyo

Copyright © The Japanese Pharmacological Society2-B-SS11-2 学生セッション（口頭）+2+Involvement of the Na /Ca exchanger in the automaticity of the pulmonaryvein myocardium, but not in the sinoatrial node, as revealed by intracellular
ion environment measurement
Ryosuke Odaka, Shogo Hamaguchi, Iyuki Namekata, Hikaru Tanaka
Dept. Pharmacol., Toho Univ. Fclt. Pharmacent. Sci

Copyright © The Japanese Pharmacological Society2-B-SS11-3 学生セッション（口頭）
Epigenetic Regulation in Diabetic Cardiomyopathy
Shunji Hirose1, Masafumi Funamoto2, Amiho Muramatsu1, Miyako Ueno1, Masaki Imanishi1,
Yasumasa Ikeda2, Koichiro Tsuchiya11Dept. of Med. Phamacol. Fac. of Farm. Tokushima Univ., 2Dept. of Pharmacol. Tokushima Univ. Grad. Sch. of
Biomed. Sci.

Copyright © The Japanese Pharmacological Society2-B-SS11-4 学生セッション（口頭）Analysis of the effect on cells by the expression of the kidney-specificubiquitin ligase RNF183, involved in degradation of ion transporters, under
hyperosmotic stress.
Yuki Higashi, Takumi Okamoto, Masayuki Kaneko
Dept. Pharmacol. Therap. Innov., Nagasaki Univ. Grad. Sch. Biomed. Sci

Copyright © The Japanese Pharmacological Society2-B-SS11-5 学生セッション（口頭）Glucagon-like Peptide 1 Receptor Agonist Attenuates Diabetic Podocyte
InjuryYoshida Akane, Miyuki Kobara, Hiroe Toba, Tetsuo Nakata
Department of Clinical Pharmacology, Kyoto Pharmaceutical University

Copyright © The Japanese Pharmacological Society2-B-SS12-1 学生セッション（口頭）Oral application of persimmon tannin significantly inhibited the halitosis andpro-inflammatory response in a Porphyromonas gulae dependent
periodontal disease in dogs.
Toyooka Megu1, Mao Kaneki1, Chiharu Ohira1, Jumpei Uchiyama2, Tomoki Fukuyama1
1Lab. of Pharmacol., Sch. of Vet. Med., Azabu Univ., 2Dept. of Bacteriol., Grad. Sch. of Med. Dent. & Pharmaceut.
Sci., Okayama Univ.

Copyright © The Japanese Pharmacological Society2-B-SS12-2 学生セッション（口頭）Role of Kv1.6 channel in chondrocytes in osteoarthritis
Tomo Kurata1, Yoshiaki Suzuki1, Shinya Tateno1, Shigeru Miyaki2, Bernotiene Elva3,
Giles Wayne4, Hisao Yamamura1
1Dept. Mol. & Cell. Pharmacol., Grad. Sch. Pharmaceut. Sci., Nagoya City Univ., 2Dept. Orthopaedic Surg., Grad.
Sch. Biomed. & Health Sci., Hiroshima Univ., 3Dept. Regenerative Med., Innov. Med. Ctr., 4Dept. Physiol. &Pharmacol., Cumming Sch. Med., Calgary Univ.

Copyright © The Japanese Pharmacological Society2-B-SS12-3 学生セッション（口頭）Intravital imaging to visualize mechanosensing by osteocytes using ATP
dynamics
Takegami Hina1, Takanobu Fukunaga2, Masamichi Yamamoto3, Keizo Nishikawa1
1

Dept. of Med. Life Sys., Grad. Sch. of Biomed., Univ. of Doshisha, 2Fac. of Eng., Univ. of Kyushu, 3NCVC

Copyright © The Japanese Pharmacological Society2-B-SS12-4 学生セッション（口頭）Mechanisms of the inhibition of cancer cell proliferation by LAT1 inhibitors
revealed by the changes in the intracellular concentrations and function ofindividual amino acids
Kou Nishikubo1, Ryuichi Ohgaki1,2, Hiroki Okanishi1, Minhui Xu1, Hitoshi Endou3,
Yoshikatsu Kanai1,21

Dept. Bio-system Pharmacol., Grad. Sch. Med., Osaka Univ., 2Integ. Front. Res. Med. Sci. Div., OTRI, Osaka
Univ., 3J-Pharma Co., Ltd.

Copyright © The Japanese Pharmacological Society2-B-SS12-5 学生セッション（口頭）Effect of sensory neuron-derived growth factors on acquired resistance tomolecular-targeted therapies for epidermal growth factor receptor-mutatednon-small cell lung cancer
Hitoshi Makabe1,2, Michiko Narita2, Yukari Suda1,2, Yukino Ide1, Shin Iizuka1,2, Yasuyuki Nagumo2,
Naoko Kuzumaki1,2, Minoru Narita1,21

Dept. Pharmacol., Hoshi Univ., Tokyo, Japan, 2Div. Pathophysiol., Natl. Cancer Ctr. Res. Inst., Tokyo, Japan

Copyright © The Japanese Pharmacological Society2-B-SS12-6 学生セッション（口頭）Role of DNA damage response protein BRAT1 in the mechanisms of cell
death induced by a novel anticancer compound ACAGT-007a
Tanaka Tatsuya, Sugiura Reiko
Dept. Molecular Pharmacogenomics. Kindai Univ.

Copyright © The Japanese Pharmacological Society2-B-SS12-7 学生セッション（口頭）Exploring responsible molecules increased in blood circulation, which
control subject well-being
Higashiyama Ayaka1,2, Yuna Inada2, Chihiro Tohda2
1

Section of Neuromedical Science, Institute of Natural Medicine, University of Toyama, 2Section of Neuromedical
Science, Institute of Natural Medicine, University of Toyama

Copyright © The Japanese Pharmacological Society3-B-SS13-1 学生セッション（口頭）Arcadlin induction reduces dendritic spine density in the hippocampal
dentate gyrus following cerebral ischemia
Nakazawa Shuma, Yosuke Inoue, Shota Inoue, Natsumi Yamaguchi, Jin Nakatani,
Toshinori Sawano, Hidekazu Tanaka
Lab. Pharmacol., Dept. Life Sci., Ritsumeikan Univ.

Copyright © The Japanese Pharmacological Society3-B-SS13-2 学生セッション（口頭）The PAD4-specific inhibitor GSK484 affords neuroprotection in neonatal
hypoxic ischemic brain injury
Xiaoping Yu1,2, Kai Le2
1

Nanchang Univ. The First Clinical Med. Coll., 2The First Affiliated Hosp. of Nanchang Univ. Dept. of
Rehabilitation Med.

Copyright © The Japanese Pharmacological Society3-B-SS13-3 学生セッション（口頭）Neuroprotective effects of MA-5, a mitochondrial activator on cerebral
ischemia/reperfusion injury
Shinomi Sasaibe, Yukie Yoshioka, Shinsuke Nakamura, Masamitsu Shimazawa
Dept. Biofunctional Evaluation., Gifu Pharmaceut. Univ.

Copyright © The Japanese Pharmacological Society3-B-SS13-4 学生セッション（口頭）LPS from P. gingivalis enhances inflammatory responses of microglia duringexposure to amyloid beta
Gui Shuge1, Zhou Wu2,3, Tomomi Sano2, Takashi Kanematsu2
1

Dept. Oral Maxillofac. Surg. Kyushu Univ., 2Dept. Cell Biol., Aging Sci. Pharmacol., Kyushu Univ., 3OBT ResearchCenter, Kyushu Univ.

Copyright © The Japanese Pharmacological Society3-B-SS13-5 学生セッション（口頭）Elucidation of the Immune Environment and Involvement of Astrocytes inMetastatic Brain Tumors
Sato Keitaro1, Hiroaki Kato1, Toya Okawa1, Goto Momoko1, Mao Watanabe1, Chika Matsumoto2,
Hiroki Tanaka2, Hidetaka Akita2, Akihiro Hisaka1, Hiromi Sato1
1

Clinical Pharmacology & Pharmacometrics, Grad. Sch. Pharmaceut. Sci., Chiba Univ.,, 2DDS Design and Drug
Disposition, Grad. Sch. Pharmaceut. Sci., Tohoku Univ.

Copyright © The Japanese Pharmacological Society3-B-SS13-6 学生セッション（口頭）Exploration of novel therapeutic agents for adenosine deaminase 2
deficiency using a larval zebrafish.
Hikaru Ishisaka1, Masahito Sawahata2, Daisuke Uta2, Toshiaki Kume2
1

Dept. Appl. Pharmacol, Grad. Sch. Med. & Pharmaceut. Sci, Univ. Toyama, 2Dept. Appl. Pharmacol, Grad. Sch.
Med. & Pharmaceut. Sci, Univ. Toyama

Copyright © The Japanese Pharmacological Society3-B-SS13-7 学生セッション（口頭）Effect of aromatic-turmerone analogues on the activities of chaperonemediated autophagy and microautophagy
Motomura Kensuke1, Boateng Alex2, Masaharu Sugiura2, Yuki Kurauchi1, Hiroshi Katsuki1,
Takahiro Seki3
1

Dept Chemico-Pharmacol Sci, Grad Sch Pharm Sci, Kumamoto Univ, 2Grad Sch Pharm Sci, Sojo Univ, 3Dept
Pharmacol, Fac Pharm Sci, Himeji Dokkyo Univ

Copyright © The Japanese Pharmacological Society3-B-SS14-1 学生セッション（口頭）Differential toxicity and localization of arginine-rich C9ORF72 dipeptide
repeat proteins depend on de-clustering of positive charges
Tamami Miyagi, Kohsuke Kanekura
Department of Pharmacology, Tokyo Medical University

Copyright © The Japanese Pharmacological Society3-B-SS14-2 学生セッション（口頭）Involvement of tryptophan metabolism in the pentylenetetrazol-induced
epileptic seizures of mice
Takaya Nishikawa1, Akihiro Mouri1,6, Kazuo Kunisawa1, Masaya Hasegawa1, Shuhei Yamagishi1,
Takatoshi Sakata1, Tomoya Sugai2, Noriki Kutsumura2,3, Kuniaki Saito4,5, Toshitaka Nabeshima5,61

Dept. Regulatory Sci., Grad. Sch. Health Sci., Fujita Health Univ., 2International Institute for Integr. Sleep Med.
(WPI-IIIS), Univ. of Tsukuba, 3Grad. Sch. of Pure and Appl. Sci., Univ. of Tsukuba,4Dept. Disease Control &Prevention., Grad. Sch. Health Sci., Fujita Health Univ., 5Lab. Health & Med. Sci. Innov., Grad. Sch. Health Sci.,
Fujita Health Univ., 6NPO. J-DO

Copyright © The Japanese Pharmacological Society3-B-SS14-3 学生セッション（口頭）Pharmacological effects of bioactive phospholipids on cellular dysfunction
caused by seed-dependent alpha-synuclein aggregation
Furukawa Masaya1, Tamotsu Tsukahara1, Miku Tanaka1, Masanori Sasaki1, Yoshikazu Matsuda2,
Hisao Haniu3
1

Dept. of Pharmacol. and Therap. Innov., Nagasaki Univ. Grad. Sch. of Biomed. Sci., 2Div. of Clin. Pharmacol. andPharmaceutics, Nihon Pharmaceut. Univ., 3Inst. for Biomed. Sci., Interdiscip. Cluster for Cutting Edge Res.,
Shinshu Univ.

Copyright © The Japanese Pharmacological Society3-B-SS14-4 学生セッション（口頭）Ciliary rootlet morphology shows distinct pattern in each region of mousebrain
Akinori Takayama, Kenshiro Uemura, Nana Koyama, Kaito Hannoe, Miu Hayashi,
Zhongyang Xiao, Jin Nakatani, Toshinori Sawano, Hidekazu Tanaka
Crs. Biomed., Grad. Sch. Life Sci., Univ. Ritsumeikan.

Copyright © The Japanese Pharmacological Society3-B-SS14-5 学生セッション（口頭）Dexmedetomidine alters hippocampal astrocyte morphology via α2adrenoceptor in vivo.
1

2

1

1

1

Watanuki Shu , Taisuke Kitano , Ryota Eguchi , Kohei Morimoto , Ken-ichi Otsuguro
1

Lab. Pharmacol., Fac. Vet. Med., Hokkaido Univ., 2Lab. Vet. Biochem., Sch. Vet. Med., Kitasato Univ.

Copyright © The Japanese Pharmacological Society3-B-SS14-6 学生セッション（口頭）Unveiling Neuro-behavioral and -histological changes in mice lacking three
genes in the human 3p26.3 locus
Shindo Asuka1, Moka Tsuchiya1, Nozomi Tanaka1, Asami Oguro-Ando2, Eri Segi-Nishida11Dept of Biol Sci and Tech, Fac of Adv Eng, Tokyo Univ of Sci, 2Univ of Exeter Med Sch, Dept of Clin and Biomed
Sci

Copyright © The Japanese Pharmacological Society