＜生命医科学域＞

目

次神経内分泌学 ……………………………………………………………………………………３
解剖学・発生学 …………………………………………………………………………………３
神経生物学 ………………………………………………………………………………………６
診断病理学 ………………………………………………………………………………………６
実験病理学 ………………………………………………………………………………………８
腎・血管病理学 …………………………………………………………………………………８
システム神経科学 ………………………………………………………………………………９
認知行動神経科学 ………………………………………………………………………………９
生殖生化学 ……………………………………………………………………………………１０
分子細胞生物学 ………………………………………………………………………………１０
遺伝子制御学 …………………………………………………………………………………１０
分子腫瘍学 ……………………………………………………………………………………１１
生理化学 ………………………………………………………………………………………１２
生体シグナル制御学 …………………………………………………………………………１２
分子薬理学 ……………………………………………………………………………………１３分子神経生物学 ………………………………………………………………………………１３分子ウイルス学 ………………………………………………………………………………１３
微生物学 ………………………………………………………………………………………１４
免疫学 …………………………………………………………………………………………１５
遺伝医学 ………………………………………………………………………………………１７
分子遺伝疫学・社会健康医学 ………………………………………………………………１８ゲノム生物学 …………………………………………………………………………………２２
再生幹細胞生物学 ……………………………………………………………………………２２
医工学 …………………………………………………………………………………………２２
実験動物学 ……………………………………………………………………………………２２
医学物理学 ……………………………………………………………………………………２３
放射線生物学 …………………………………………………………………………………２７
生命反応化学 …………………………………………………………………………………２８
環境生物学 ……………………………………………………………………………………２８
環境分子生物学 ………………………………………………………………………………３０
環境微生物学 …………………………………………………………………………………３０
分子発生生物学 ………………………………………………………………………………３１
環境保健学（産業精神医学・宇宙医学） …………………………………………………３１

神経内分泌学
1) 英文論文
1. Nogami H, Yamamoto N, Hiraoka Y, Aiso S, Sugimoto K, Yoshida S, Shutoh F, Hisano S. Rapid
induction of the growth hormone gene transcription by glucocorticoids in vitro: possible
involvement of membrane glucocorticoid receptors and phosphatidylinositol 3-kinase activation. J
Neuroendocrinol 26(3):195-204, 2014
2. Sugimoto K, Ohmomo H, Shutoh F, Nogami H, Hisano S. Presentation of noise during acute restraint
stress attenuates expression of immediate early genes and arginine vasopressin in the hypothalamicparaventricular nucleus but not corticosterone secretion in rats. Neurosci Res doi:
10.1016/j.neures.2014.11.010, 2014

解剖学・発生学
1) 英文論文
1. Daussy C, Faure F, Mayol K, Viel S, Gasteiger G, Charrier E, Bienvenu J, Henry T, Debien E, Hasan
UA, Marvel J, Yoh K, Takahashi S, Prinz I, de Bernard S, Buffat L, Walzer T. T-bet and Eomes
instruct the development of two distinct natural killer cell lineages in the liver and in the bonemarrow. J Exp Med 211(3):563-577, 2014
2. Eto K, Nishimura W, Oishi H, Udagawa H, Kawaguchi M, Hiramoto M, Fujiwara T, Takahashi S,
Yasuda K. MafA is required for postnatal proliferation of pancreatic beta-cells. PLoS One
9(8):e104184, 2014
3. Fernando V, Omura S, Sato F, Kawai E, Martinez NE, Elliott SF, Yoh K, Takahashi S, Tsunoda I.
Regulation of an autoimmune model for multiple sclerosis in Th2-biased GATA3 transgenic mice.
Int J Mol Sci 15(2):1700-1718, 2014
4. Hamada M, Nakamura M, Tran MT, Moriguchi T, Hong C, Ohsumi T, Dinh TT, Kusakabe M,
Hattori M, Katsumata T, Arai S, Nakashima K, Kudo T, Kuroda E, Wu CH, Kao PH, Sakai M,
Shimano H, Miyazaki T, Tontonoz P, Takahashi S. MafB promotes atherosclerosis by inhibiting
foam-cell apoptosis. Nat Commun 5:3147, 2014
5. Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M,
Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Generation andcharacterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP
recombination. Exp Anim 63(2):183-191, 2014
6. Iizuka M, Tsuboi H, Matsuo N, Asashima H, Hirota T, Kondo Y, Iwakura Y, Takahashi S, Matsumoto
I, Sumida T. A crucial role of RORt in the development of spontaneous Sialadenitis-like Sjogren's
3syndrome. J Immunol doi: 10.4049/jimmunol.1401118, 2014
7. Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S,
Nakauchi H, Ishii Y. T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of
myeloid

cells

and

impairsfunctionofmacrophages

in

the

lung.

Blood

doi:

10.1182/blood-2014-05-575225, 2014
8. Kamath-Loeb AS, Balakrishna S, Whittington D, Shen JC, Emond MJ, Okabe T, Masutani C,
Hanaoka F, Nishimura S, Loeb LA. Sphingosine, a modulator of human translesion DNA polymerase
activity. J Biol Chem 289(31):21663-21672, 2014
9. Kihara M, Ito K, Nakata J, Otani M, Tran NL, Morito N, Takahashi S, Wada Y, Izui S. O-linked
glycosylation determines the nephritogenic potential of IgA rheumatoid factor. J Am Soc Nephrol25(6):1282-1290, 2014
10. Martinez NE, Sato F, Kawai E, Omura S, Takahashi S, Yoh K, Tsunoda I. Th17-biased RORttransgenic mice become susceptible to a viral model for multiple sclerosis. Brain Behav Immun doi:
10.1016/j.bbi.2014.07.008, 2014
11. Martinez NE, Sato F, Omura S, Kawai E, Takahashi S, Yoh K, Tsunoda I. RORgammat, but not
T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis. J Neuroimmunol276(1-2):142-149, 2014
12. Matsuyama M, Ishii Y, Yageta Y, Ohtsuka S, Ano S, Matsuno Y, Morishima Y, Yoh K, Takahashi S,
Ogawa K, Hogaboam CM, Hizawa N. Role of Th1/Th17 balance regulated by T-bet in a mousemodel of Mycobacterium avium complex disease. J Immunol 192(4):1707-1717, 2014
13. Miyazaki T, Ikeda K, Horie-Inoue K, Kondo T, Takahashi S, Inoue S. EBAG9 modulates hostimmune defense against tumor formation and metastasis by regulating cytotoxic activity of T
lymphocytes. Oncogenesis 3:e126, 2014
14. Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M,
Takahashi S, Sugiyama F, Yagami K. Simple generation of albino C57BL/6J mice with G291T
mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome 25(7-8):327-334,
2014
15. Morito N, Yoh K, Ojima M, Okamura M, Nakamura M, Hamada M, Shimohata H, Moriguchi T,
Yamagata K, Takahashi S. Overexpression of Mafb in podocytes protects against diabetic
nephropathy. J Am Soc Nephrol 25(11):2546-2557, 2014
16. Nagasaki H, Katsumata T, Oishi H, Tai PH, Sekiguchi Y, Koshida R, Jung Y, Kudo T, Takahashi S.
Generation of insulin-producing cells from the mouse liver using beta cell-related gene transfer
including Mafa and Mafb. PLoS One 9(11):e113022, 2014
17. Nishikawa Y, Nishijima H, Matsumoto M, Morimoto J, Hirota F, Takahashi S, Luche H, Fehling HJ,
Mouri Y, Matsumoto M. Temporal lineage tracing of Aire-expressing cells reveals a requirement forAire in their maturation program. J Immunol 192(6):2585-2592, 20144

18. Nishimura W, Oishi H, Funahashi N, Fujiwara T, Takahashi S, Yasuda K. Generation andcharacterization of MafA-Kusabira Orange mice. Endocr J doi: 10.1507/endocrj.EJ14-0296, 2014
19. Nishimura W, Takahashi S, Yasuda K. MafA is critical for maintenance of the mature beta cell
phenotype in mice. Diabetologia doi: 10.1007/s00125-014-3464-9, 2014
20. Okamura M, Yoh K, Ojima M, Morito N, Takahashi S. Overexpression of GATA-3 in T cells
accelerates dextran sulfate sodium-induced colitis. Exp Anim 63(2):133-140, 2014
21. Shinagawa T, Takagi T, Tsukamoto D, Tomaru C, Huynh LM, Sivaraman P, Kumarevel T, Inoue K,
Nakato R, Katou Y, Sado T, Takahashi S, Ogura A, Shirahige K, Ishii S. Histone variants enriched inoocytes enhance reprogramming to induced pluripotent stem cells. Cell Stem Cell 14(2):217-227,
2014
22. Suzuki K, Numata T, Suzuki H, Raga DD, Ipulan LA, Yokoyama C, Matsushita S, Hamada M,
Nakagata N, Nishinakamura R, Kume S, Takahashi S, Yamada G. Sexually dimorphic expression of
Mafb regulates masculinization of the embryonic urethral formation. Proc Natl Acad Sci U S A
111(46):16407-16412, 2014
23. Tojo M, Fujita T, Ainoda Y, Nagamatsu M, Hayakawa K, Mezaki K, Sakurai A, Masui Y, Yazaki H,
Takahashi H, Miyoshi-Akiyama T, Totsuka K, Kirikae T, Ohmagari N. Evaluation of an automatedrapid diagnostic assay for detection of Gram-negative bacteria and their drug-resistance genes inpositive blood cultures. PLoS One 9(4):e94064, 2014
24. Tojo M, Nagamatsu M, Hayakawa K, Mezaki K, Kirikae T, Ohmagari N. Evaluation of an
automated rapid diagnostic test for detection of Clostridium difficile. PLoS One 9(8):e106102, 2014
25. Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In
vivo image analysis using iRFP transgenic mice. Exp Anim 63(3):311-319, 20143) 英文著書
1. Hamada M, Takahashi S. Chapter 25. Functions of the Large Maf Transcription Factors andMacrophages; in "Macrophages: Biology and Role in the Pathology of Diseases (1st edition)" (editedby Biswas SK, Mantovani A), Springer (New York) 2014; pp509-517
4) 英文以外の著書
1. 工藤崇. 249 巻 8 号. 血小板減少症を呈するムチン O-結合型糖鎖欠損マウスの解析; "医学のあゆみ (第 1 版)” 医歯薬出版株式会社 (東京) 2014; 688-692.
2. 工藤崇. 第 68 巻第 5 号. 巨核球分化におけるムチン型糖鎖修飾の意義; "血液内科 (第 1 版)” 科
学評論社 (東京) 2014; 698-703.
3. 濱田理人. 2014 年 9 月号. MafB は悪玉コレステロールによる刺激を伝え, 泡沫細胞の蓄積を促進し動脈硬化の原因となる; "月刊バイオインダストリー (第 1 版)” シーエムシー出版
2014; 19-25
5神経生物学1) 英文論文
1. Masuda T, Sakuma C, Nagaoka A, Yamagishi T, Ueda S, Nagase T, Yaginuma H. Follistatin-like 5 isexpressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory
system. Congenit Anom (Kyoto) 54(1):63-66, 2014
2. Namba T, Kibe Y, Funahashi Y, Nakamuta S, Takano T, Ueno T, Shimada A, Kozawa S, Okamoto M,
Shimoda Y, Oda K, Wada Y, Masuda T, Sakakibara A, Igarashi M, Miyata T, Faivre-Sarrailh C,
Takeuchi K, Kaibuchi K. Pioneering axons regulate neuronal polarization in the developing cerebral
cortex. Neuron 81(4):814-829, 2014
3. Ohtani A, Kozono N, Senzaki K, Shiga T. Serotonin 2A receptor regulates microtubule assembly andinduces dynamics of dendritic growth cones in rat cortical neurons in vitro. Neurosci Res
81-82:11-20, 2014

診断病理学1) 英文論文
1. Itoguchi N, Nakagawa T, Murata Y, Li D, Shiba-Ishii A, Minami Y, Noguchi M.
Immunocytochemical staining for stratifin and OCIAD2 in bronchial washing specimens increases
sensitivity for diagnosis of lung cancer. Cytopathology doi: 10.1111/cyt.12220, 2014
2. Kawai H, Satomi K, Morishita Y, Murata Y, Sugano M, Nakano N, Noguchi M. Developmental
markers of ganglion cells in the enteric nervous system and their application for evaluation of
Hirschsprung disease. Pathol Int 64(9):432-442, 2014
3. Kenmotsu H, Niho S, Ito T, Ishikawa Y, Noguchi M, Tada H, Sekine I, Watanabe S, Yoshimura M,
Yamamoto N, Oshita F, Kubota K, Nagai K. A pilot study of adjuvant chemotherapy with irinotecan
and cisplatin for completely resected high-grade pulmonary neuroendocrine carcinoma (large cell
neuroendocrine carcinoma and small cell lung cancer). Lung Cancer 84(3):254-258, 2014
4. Murata Y, Minami Y, Iwakawa R, Yokota J, Usui S, Tsuta K, Shiraishi K, Sakashita S, Satomi K,
Iijima T, Noguchi M. ECT2 amplification and overexpression as a new prognostic biomarker forearly-stage lung adenocarcinoma. Cancer Sci 105(4):490-497, 2014
5. Nakamura Y, Matsumoto K, Satoh T, Nishide K, Nozue A, Shimabukuro K, Endo S, Nagai K, Oki A,
Minaguchi T, Morishita Y, Noguchi M, Yoshikawa H. Optimizing biopsy procedures duringcolposcopy for women with abnormal cervical cancer screening results: a multicenter prospective
study. Int J Clin Oncol doi: 10.1007/s10147-014-0739-6, 2014
6. Ohara R, Michikami H, Nakamura Y, Sakata A, Sakashita S, Satomi K, Shiba-Ishii A, Kano J,
6Yoshikawa H, Noguchi M. Moesin overexpression is a unique biomarker of adenomyosis. Pathol Int
64(3):115-122, 2014
7. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N,
Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y,
Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K,
Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K,
Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet
46(2):171-175, 2014
8. Satomi K, Yoshida M, Matsuoka K, Okita H, Hosoya Y, Shioda Y, Kumagai MA, Mori T, Morishita
Y, Noguchi M, Nakazawa A. Myelopathy mimicking subacute combined degeneration in a Down
syndrome patient with methotrexate treatment for B lymphoblastic leukemia: report of an autopsy
case. Neuropathology 34(4):414-419, 2014
9. Takaoka E, Miyazaki J, Kimura T, Kojima T, Kawai K, Murata Y, Itoguchi N, Minami Y, Nakamura
T, Honda K, Nishiyama H. Concurrent urothelial carcinoma in the renal pelvis of an allograft kidneyand native recipient bladder: evidence of donor origin. Jpn J Clin Oncol 44(4):366-369, 2014
10. Thunnissen E, Noguchi M, Aisner S, Beasley MB, Brambilla E, Chirieac LR, Chung JH, Dacic S,
Geisinger KR, Hirsch FR, Ishikawa Y, Kerr KM, Lantejoul S, Matsuno Y, Minami Y, Moreira AL,
Pelosi G, Petersen I, Roggli V, Travis WD, Wistuba I, Yatabe Y, Dziadziuszko R, Witte B, Tsao MS,
Nicholson AG. Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: aninternational multiobserver study. J Thorac Oncol 9(9):1354-1362, 2014
11. Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M. TMEPAI/PMEPA1 enhances
tumorigenic activities in lung cancer cells. Cancer Sci 105(3):334-341, 20142) 英文以外の論文
1. 黒部匡広, 小島崇宏, 高岡栄一郎, 辻本一平, 目翔太郎, 市岡大士, 神鳥周也, 常楽晃, 末富崇弘,
宮崎淳, 河合弘二, 西山博之, 萩谷千裕, 坪井洋人, 住田孝之, 佐藤泰樹, 里見介史, 野口雅之.
腎盂癌との鑑別が困難であった IgG4 関連疾患の 1 例

本邦文献例の検討. 泌尿器外科

27(11):1849-1854, 2014
2. 竹内朋代, 野口雅之. 生体試料バンキングの現状と将来. 呼吸 33(6):548-551, 2014
3. 中野雅之, 南優子, 野口雅之. 新しい肺腺癌病理分類. 呼吸器内科 25(5):482-488, 20143) 英文著書
1. Wistuba I, Brambilla E, Noguchi M. 17. Classic anatomic pathology and lung cancer; in "The IASLC
Multidisciplinary Approach to Thoracic Oncology" (edited by Pass HI, Ball D, Scagliotti GV ),IASLC International Association for the Study of Lung Cancer (Boston) 2014; pp217-240

7実験病理学1) 英文論文
1. Azami S, Vo Nguyen TT, Watanabe Y, Kato M. Cooperative induction of transmembrane prostate
androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-beta and epidermal
growth factor signaling. Biochem Biophys Res Commun dio: 10.1016/j.bbrc.2014.11.107, 2014
2. Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo
Nguyen TT, Watanabe Y, Kato M, Itoh S. C18 ORF1: A Novel Negative Regulator of transforming
growth factor-beta signaling. J Biol Chem 289(18):12680-12692, 2014
3. Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S, Kato M. TMEPAI/PMEPA1 enhances
tumorigenic activities in lung cancer cells. Cancer Sci 105(3):334-341, 2014
4. Dahl M, Maturi V, L.ANvnn P, Papoutsoglou P, Zieba A, Vanlandewijck M, van der Heide
LP, WatanabeY, SNvderberg O, Hottiger MO, Heldin CH, Moustakas A. Fine-tuning of Smad proteinfunction by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase duringtransforming growth factor-beta signaling. PLoS One 9(8):e103651 2014.

腎・血管病理学1) 英文論文
1. Hara S, Kawano M, Mizushima I, Yamada K, Fujita K, Harada K, Matsumura M, Yamagishi M, SatoY, Yamaguchi Y, Nakanuma Y, Nagata M. A condition closely mimicking IgG4-related disease
despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Mod
Rheumatol 1-6, 2014
2. Hara S, Umeyama K, Yokoo T, Nagashima H, Nagata M. Diffuse glomerular nodular lesions indiabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritantdiabetic gene in humans. PLoS One 9(3):e92219, 2014
3. Iijima K, Sako M, Oba MS, Ito S, Hataya H, Tanaka R, Ohwada Y, Kamei K, Ishikura K, Yata N,
Nozu K, Honda M, Nakamura H, Nagata M, Ohashi Y, Nakanishi K, Yoshikawa N. Cyclosporine C2
monitoring for the treatment of frequently relapsing nephrotic syndrome in children: a multicenter
randomized phase II trial. Clin J Am Soc Nephrol 9(2):271-278, 2014
4. Ikezumi Y, Suzuki T, Karasawa T, Kaneko U, Yamada T, Hasegawa H, Nagata M, Saitoh A.
Glomerular epithelial cell phenotype in diffuse mesangial sclerosis: a report of 2 cases with markedly
increased urinary podocyte excretion. Hum Pathol 45(8):1778-1783, 201484) 英文以外の著書
1. 上野智敏, 長田道夫. 250 巻. 巣状分節性糸球体硬化症（FSGS）における Notch シグナルの役
割; "医学のあゆみ”, 医歯薬出版株式会社 (東京) 2014; pp594-295
2. 上杉憲子, 長田道夫. 56 (2). 血管炎の病理; "日本腎臓学会誌” (編集 日本腎臓学会), 東京医学社

(東京) 2014; pp87-97

3. 原怜史, 上杉憲子, 長田道夫. 全身性エリテマトーデス(尿細管間質病変を中心に); "IgG4 関連腎臓病のすべて (第 1 版)” (編集 斎藤喬雄, 西愼一), 南江堂 (東京) 2014; pp138-140
4. 原怜史, 上杉憲子, 長田道夫. 血管炎症候群(ANCA 関連血管炎); "IgG4 関連腎臓病のすべて(第 1 版)” (編集 斎藤喬雄, 西愼一), 南江堂 (東京) 2014; pp151-153
5. 長田道夫. Bird’s eye と storiform pattern; "IgG4 関連腎臓病のすべて (第 1 版)” (編集 斉藤喬雄,西慎一), 南江堂 (東京) 2014; pp95

システム神経科学
1) 英文論文
1. Borgius L, Nishimaru H, Caldeira V, Kunugise Y, Low P, Reig R, Itohara S, Iwasato T, Kiehn O.
Spinal glutamatergic neurons defined by EphA4 signaling are essential components of normal
locomotor circuits. J Neurosci 34(11):3841-3853, 2014
2. Ohyama K, Sugase-Miyamoto Y, Matsumoto N, Sato C, Shidara M. Small effect of upcoming reward
outcomes on visual cue-related neuronal activity in macaque area TE during conditional associations.
Neurosci Res 88:28-38, 2014
3. Setogawa T, Mizuhiki T, Matsumoto N, Akizawa F, Shidara M. Self-choice enhances value inreward-seeking in primates. Neurosci Res 80:45-54, 2014
4. Shidara M. Reward expectancy signals in monkey anterior cingulate cortex and its relation toreinforcement learning. Alcohol Alcohol Suppl1:i30, 2014

認知行動神経科学
1) 英文論文
1. Koganezawa T, Paton JF. Intrinsic chemosensitivity of rostral ventrolateral medullary sympathetic
premotor neurons in the in situ arterially perfused preparation of rats. Exp Physiol
99(11):1453-1466, 201492) 英文以外の論文
1. 山田洋, 榎本一紀. 罰を表現するドーパミン細胞と手綱核. Clinical Neuroscience 32(1):47-50,
2014

生殖生化学
1) 英文論文
1. Katoh Y, Takebayashi K, Kikuchi A, Iki A, Kikuchi K, Tamba M, Kawashima A, Matsuda M,
Okamura N. Porcine sperm capacitation involves tyrosine phosphorylation and activation of aldose
reductase. Reproduction 148(4):389-401, 2014
2. Matsuda M, Kurosaki K, Okamura N. Activated vitamin D3 and pro-activated vitamin D3 attenuate
induction of permanent changes caused by neonatal estrogen exposure in the mouse vagina. J Reprod
Dev 60(4):274-279, 2014

分子細胞生物学
1) 英文論文
1. Uemura T, Suda Y, Ueda T, Nakano A. Dynamic behavior of the trans-golgi network in root tissues of
Arabidopsis revealed by super-resolution live imaging. Plant Cell Physiol 55(4):694-703, 20142) 英文以外の論文
1. 木村雄一, 入江賢児. ATXN2 の酵母オルソログ Pbp1 はリボソーム蛋白質と協調して増殖を制御する. 医学のあゆみ 250(3):225-226, 2014

遺伝子制御学1) 英文論文
1. Nishimura K, Kato T, Chen C, Oinam L, Shiomitsu E, Ayakawa D, Ohtaka M, Fukuda A, Nakanishi
M, Hisatake K. Manipulation of KLF4 expression generates iPSCs paused at successive stages ofreprogramming. Stem Cell Reports 3(5):915-929, 2014
2. Takayama K, Morisaki Y, Kuno S, Nagamoto Y, Harada K, Furukawa N, Ohtaka M, Nishimura K,
Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Noguchi E, Nakanishi M, Hirata K, Kawabata K,
Mizuguchi H. Prediction of interindividual differences in hepatic functions and drug sensitivity by
10using human iPS-derived hepatocytes. Proc Natl Acad Sci U S A 111(47):16772-16777, 2014
3. Tanaka A, Akimoto Y, Kobayashi S, Hisatake K, Hanaoka F, Ohkuma Y. Association of the winged
helix motif of the TFIIEalpha subunit of TFIIE with either the TFIIEbeta subunit or TFIIB
distinguishes its functions in transcription. Genes Cells doi:10.1111/gtc.12212, 2014
4. Trokovic R, Weltner J, Nishimura K, Ohtaka M, Nakanishi M, Salomaa V, Jalanko A, Otonkoski T,
Kyttala A. Advanced feeder-free generation of induced pluripotent stem cells directly from blood
cells. Stem Cells Transl Med 3(12):1402-1409, 20144) 英文以外の著書
1. 福田綾, 久武幸司. 250 巻 2 号. RNA 結合蛋白質 hnRNP R を介した c-fos遺伝子の転写調節; “医学のあゆみ” 医歯薬出版株式会社 (東京) 2014; pp145-146

分子腫瘍学1) 英文論文
1. Kato T, Sakata-Yanagimoto M, Nishikii H, Ueno M, Miyake Y, Yokoyama Y, Asabe Y, Kamada Y,
Muto H, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H,
Kageyama R, and Chiba S. Hes1 suppresses acute myeloid leukemia development through FLT3
repression. Leukemia doi: 10.1038/leu.2014.281, 2014
2. Miwa M, Honjo S, You G, Tanaka M, Uchida K, Srivatanakul P, Khuhaprema T, Loilome W,
Techasen A, Wongkham C, Limpaiboon T, Yongvanit P, and Wongkham S. Genetic andenvironmental determinants of risk for cholangiocarcinoma in Thailand. World J Gastrointest
Pathophysiol 5(4):570-578, 2014
3. Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y,
Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa
S, and Chiba S. Reduced TET2 function leads to T-cell lymphoma with follicular helper T-cell-likefeatures in mice. Blood Cancer J 4:e264, 2014
4. Tameda M, Sugimoto K, Shiraki K, Yamamoto N, Okamoto R, Usui M, Ito M, Takei Y, Nobori T,
Kojima T, Suzuki H, Uchida M, and Uchida K. Collagen triple helix repeat containing 1 isoverexpressed in hepatocellular carcinoma and promotes cell proliferation and motility. Int J Oncol
45(2):541-548, 2014

11

生理化学
1) 英文論文
1. Akiyama M, Hasegawa H, Hongu T, Frohman MA, Harada A, Sakagami H, Kanaho Y.
Trans-regulation of oligodendrocyte myelination by neurons through small GTPase Arf6-regulated
secretion of fibroblast growth factor-2. Nat Commun 5:4744, 2014
2. Funakoshi Y, Chou MM, Kanaho Y, Donaldson JG. TRE17/USP6 regulates ubiquitylation andtrafficking of cargo proteins that enter cells by clathrin-independent endocytosis. J Cell Sci
127(21):4750-4761, 2014
3. Hongu T, Kanaho Y. Activation machinery of the small GTPase Arf6. Adv Biol Regul 54:59-66,
2014
4. Ogami K, Hosoda N, Funakoshi Y, Hoshino S. Antiproliferative protein Tob directly regulates c-myc
proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB.
Oncogene 33(1):55-64, 2014
5. Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA,
Huang P. Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle
regeneration. Mol Biol Cell doi: 10.1091/mbc.E14-03-0802, 20142) 英文以外の論文
1. 本宮綱記, 佐藤隆信, 船越祐司, 金保安則. 好中球における活性酸素産生および酵素放出の分子メカニズム解析

ホスホリパーゼ D は必要か? 脂質生化学研究 56:89-91, 2014

生体シグナル制御学
1) 英文論文
1. Moriya S, Hayata T, Notomi T, Aryal S, Nakamaoto T, Izu Y, Kawasaki M, Yamada T, Shirakawa J,
Kaneko K, Ezura Y, Noda M. PTH regulates β2-adrenergic receptor expression in osteoblast-like
MC3T3-E1 cells. J Cell Biochem doi: 10.1002/jcb.24953, 2014
2. Ezura Y, Nagata J, Nagao M, Hemmi H, Hayata T, Rittling S, Denhardt DT, Noda M.
Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation
associated with OPN expression in circulating blood cells. J Bone Miner Metab doi:
10.1007/s00774-014-0568-8, 2014
3. Shirakawa J, Ezura Y, Moriya S, Kawasaki M, Yamada T, Notomi T, Nakamoto T, Hayata T,
Miyawaki A, Omura K, Noda M. Migration linked to FUCCI-indicated cell cycle is controlled by
PTH and mechanical stress. J Cell Physiol 229(10):1353-1358, 201412

4. Watanabe C, Morita M, Hayata T, Nakamoto T, Kikuguchi C, Li X, Kobayashi Y, Takahashi N,
Notomi T, Moriyama K, Yamamoto T, Ezura Y, Noda M. Stability of mRNA influences osteoporoticbone mass via CNOT3. Proc Natl Acad Sci U S A 111(7):2692-2697, 20142) 英文以外の論文
1. 野田政樹, 早田匡芳, 渡辺千穂, 白川純平, 守屋秀一, 山田峻之, 江面陽一. 骨におけるメッセ
ンジャーRNA の安定性と生体制御について. 遺伝: 生物の科学 68(5):458-460, 2014

分子薬理学1) 英文論文
1. Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M,
Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Generation andcharacterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP
recombination. Exp Anim 63(2):183-191, 2014
2. Tamura M, Matsui H, Hyodo I, Tanaka J, Miwa Y. Fluorescence-based co-culture of normal andcancerous cells as an indicator of therapeutic effects in cancer. Eur J Pharm Sci 63:1-7, 2014
3. Tran MT, Tanaka J, Hamada M, Sugiyama Y, Sakaguchi S, Nakamura M, Takahashi S, Miwa Y. In
vivo image analysis using iRFP transgenic mice. Exp Anim 63(3):311-319, 2014

分子神経生物学
1) 英文論文
1. Freeman SD, Keino-Masu K, Masu M, Ladher RK. Expression of the heparan sulfate
6-O-endosulfatases, Sulf1 and Sulf2, in the avian and mammalian inner ear suggests a role forsulfation during inner ear development. Dev Dyn doi: 10.1002/dvdy.24223, 2014

分子ウイルス学
1) 英文論文
1. Czene A, Toth E, Nemeth E, Otten H, Poulsen JC, Christensen HE, Rulisek L, Nagata K, Larsen S,
Gyurcsik B. A new insight into the zinc-dependent DNA-cleavage by the colicin E7 nuclease: a13

crystallographic and computational study. Metallomics 6(11):2090-2099, 2014
2. Feillet C, Krusche P, Tamanini F, Janssens RC, Downey MJ, Martin P, Teboul M, Saito S, Levi FA,
Bretschneider T, van der Horst GT, Delaunay F, Rand DA. Phase locking and multiple oscillating
attractors for the coupled mammalian clock and cell cycle. Proc Natl Acad Sci U S A
111(27):9828-9833, 2014
3. Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y,
Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M,
Kodama T, Wada Y, Sekimizu K, Akimitsu N. Long noncoding RNA NEAT1-dependent SFPQ
relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol
Cell 53(3):393-406, 2014
4. Kadota S, Nagata K. Silencing of IFN-stimulated gene transcription is regulated by histone H1 andits chaperone TAF-I. Nucleic Acids Res 42(12):7642-7653, 2014
5. Kumakura M, Kawaguchi A, Nagata K. Actin-myosin network is required for proper assembly of
influenza virus particles. Virology doi: 10.1016/j.virol.2014.12.016, 2014
6. Murano K, Okuwaki M, Momose F, Kumakura M, Ueshima S, Newbold RF, Nagata K.
Reconstitution of human rRNA gene transcription in mouse cells by a complete SL1 complex. J Cell
Sci 127(Pt 15):3309-3319, 2014
7. Nemeth E, Kortvelyesi T, Kozisek M, Thulstrup PW, Christensen HE, Asaka MN, Nagata K,
Gyurcsik B. Substrate binding activates the designed triple mutant of the colicin E7 metallonuclease.
J Biol Inorg Chem 19(8):1295-1303, 2014
8. Nemeth E, Kortvelyesi T, Thulstrup PW, Christensen HE, Kozisek M, Nagata K, Czene A, Gyurcsik
B. Fine tuning of the catalytic activity of colicin E7 nuclease domain by systematic N-terminal
mutations. Protein Sci 23(8):1113-1122, 2014
9. Oshiro Y, Yasue H, Takahashi K, Hattori S, Ideno S, Urayama T, Chiba M, Osari S, Naito T, Takeuchi
K, Nagata K, Ohkohchi N. Mode of swine hepatitis E virus infection and replication in primary
human hepatocytes. J Gen Virol 95(Pt 12):2677-2682, 20144) 英文以外の著書
1. 川口敦史. 6. 冬のインフルエンザ; "環境と微生物の事典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp244

微生物学1) 英文論文
1. Nguyen Thi le T, Sarmiento ME, Calero R, Camacho F, Reyes F, Hossain MM, Gonzalez GS,
14

Norazmi MN, Acosta A. Immunoinformatics study on highly expressed Mycobacterium tuberculosis
genes during infection. Tuberculosis (Edinb) 94(5):475-481, 2014
2. Skorup P, Maudsdotter L, Lipcsey M, Castegren M, Larsson A, Jonsson AB, Sjolin J. Beneficial
antimicrobial effect of the addition of an aminoglycoside to a beta-lactam antibiotic in an E. coli
porcine intensive care severe sepsis model. PLoS One 9(2):e90441, 2014
3. Suwastika IN, Denawa M, Yomogihara S, Im CH, Bang WY, Ohniwa RL, Bahk JD, Takeyasu K,
Shiina T. Evidence for lateral gene transfer (LGT) in the evolution of eubacteria-derived small
GTPases in plant organelles. Front Plant Sci 5(678, 2014
4. Ushijima Y, Ohniwa RL, Maruyama A, Saito S, Tanaka Y, Morikawa K. Nucleoid compaction by
MrgA(Asp56Ala/Glu60Ala) does not contribute to staphylococcal cell survival against oxidative
stress and phagocytic killing by macrophages. FEMS Microbiol Lett 360(2):144-151, 20144) 英文以外の著書
1. 大庭良介. 第 6 章. 表層常在細菌叢と病原菌; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp252-253
2. 斎藤慎二. 第 6 章. 腸内細菌叢; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会),
朝倉書店 (東京) 2014; pp254-255
3. 斎藤慎二. 第 6 章. 細胞性免疫ｖｓ微生物; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp256-257
4. 斎藤慎二. 第 6 章. 液性免疫ｖｓ微生物; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp258-259
5. 大庭良介. 第 6 章. 酸化ストレス耐性; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp260
6. 森川一也. 第 6 章. 病原性・耐性の獲得と深化; "環境と微生物の辞典 (第 1 版)” (編集 日本微生物生態学会), 朝倉書店 (東京) 2014; pp265-266

免疫学1) 英文論文
1. Kim YG, Udayanga KG, Totsuka N, Weinberg JB, Nunez G, Shibuya A. Gut dysbiosis promotes M2
macrophage polarization and allergic airway inflammation via fungi-induced PGE(2). Cell Host
Microbe 15(1):95-102, 2014
2. Kurita N, Honda S, Shibuya A. Increased serum IgA in Fcalpha/muR-deficient mice on the (129 x
C57BL/6) F1 genetic background. Mol Immunol doi: 10.1016/j.molimm.2014.09.008, 2014
3. Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL. Costimulatory molecule15

DNAM-1 is essential for optimal differentiation of memory natural killer cells during mouse
cytomegalovirus infection. Immunity 40(2):225-234, 2014
4. Nabekura T, Lanier LL. Antigen-specific expansion and differentiation of natural killer cells by
alloantigen stimulation. J Exp Med 211(12):2455-2465, 2014
5. Nagumo Y, Iguchi-Manaka A, Yamashita-Kanemaru Y, Abe F, Bernhardt G, Shibuya A, Shibuya K.
Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice. PLoS
One 9(11):e112415, 2014
6. Nanatsue K, Ninomiya T, Tsuchiya M, Tahara-Hanaoka S, Shibuya A, Masuko H, Sakamoto T,
Hizawa N, Arinami T, Noguchi E. Influence of MILR1 promoter polymorphism on expression levels
and the phenotype of atopy. J Hum Genet 59(9):480-483, 2014
7. Sabato V, Boita M, Shubber S, Bridts CH, Shibuya A, De Clerck LS, Falcone FH, Ebo DG.
Mechanism of phosphatidylserine inhibition of IgE/FcepsilonRI-dependent anaphylactic humanbasophil degranulation via CD300a. J Allergy Clin Immunol 134(3):734-737 e733, 2014
8. Satake K, Shimizu Y, Sasaki Y, Yanagawa H, Suzuki H, Suzuki Y, Horikoshi S, Honda S, Shibuya K,
Shibuya A, Tomino Y. Serum under-O-glycosylated IgA1 level is not correlated with glomerular IgA
deposition based upon heterogeneity in the composition of immune complexes in IgA nephropathy.
BMC Nephrol 15:89, 2014
9. Tanaka T, Tahara-Hanaoka S, Nabekura T, Ikeda K, Jiang S, Tsutsumi S, Inagaki T, Magoori K,
Higurashi T, Takahashi H, Tachibana K, Tsurutani Y, Raza S, Anai M, Minami T, Wada Y, Yokote K,
Doi T, Hamakubo T, Auwerx J, Gonzalez FJ, Nakajima A, Aburatani H, Naito M, Shibuya A,
Kodama T, Sakai J. PPARbeta/delta activation of CD300a controls intestinal immunity. Sci Rep
4:5412, 2014
10. Totsuka N, Kim YG, Kanemaru K, Niizuma K, Umemoto E, Nagai K, Tahara-Hanaoka S,
Nakahasi-Oda C, Honda S, Miyasaka M, Shibuya K, Shibuya A. Toll-like receptor 4 andMAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte
migration. Nat Commun 5:4710, 20142) 英文以外の論文
1. 金丸由美, 渋谷和子. 細胞内染色法を用いたサイトカイン産生の解析. 実験医学別冊 最強のステップ UP シリーズ 直伝！フローサイトメトリー 面白いほど使いこなせる！ 90-99, 2014
2. 佐藤和貴, 本多伸一郎, 渋谷彰. 【組織における免疫応答の特性】 濾胞樹状細胞の B 細胞への抗原提示能の制御機構. 臨床免疫・アレルギー科 62(1):25-30, 2014
3. 渋谷彰. 抗生物質服用による腸内細菌バランスの乱れと喘息. メディカル朝日 43(12):32-33,
2014
4. 渋谷彰. DNAM-1(CD226)によるキラーリンパ球活性化と標的細胞傷害. 感染・炎症・免疫43(4):296-306, 201416

5. 渋谷彰. 大発見！抗生物質を投与すると腸内でカビが大繁殖してぜんそくを悪化させる. あとぴナビ 5 月号 38-39, 2014
6. 渋谷彰. 腸内細菌のバランスの乱れがぜん息を悪化させるメカニズムがわかった！ あとぴ
ナビ 4 月号 247:1-3, 2014
7. 渋谷彰. 大発見！抗生物質を投与すると腸内でカビが大繁殖してぜんそくを悪化させる. 腸の大掃除で病気は勝手に治る（『壮快』特別編集） 7 月号 32-33, 2014
8. 永井恵, 渋谷彰. プライマリマスト細胞の単離と解析. 実験医学別冊 最強のステップ UP シ
リーズ 直伝！フローサイトメトリー 面白いほど使いこなせる！ 233-242, 2014
9. 藤山聡, 澁谷彰. 【腸内細菌と疾患】 腸管内真菌と気管支喘息. 医学のあゆみ 251(1):42-48,
2014

遺伝医学
1) 英文論文
1. Hawlader MD, Ma E, Noguchi E, Itoh M, Arifeen SE, Persson LA, Moore SE, Raqib R, Wagatsuma
Y. Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi
Children. Trop Med Health 42(2):77-85, 2014
2. Hayashi M, Hirota T, Saeki H, Nakagawa H, Ishiuji Y, Matsuzaki H, Tsunemi Y, Kato T, Shibata S,
Sugaya M, Sato S, Tada Y, Doi S, Miyatake A, Ebe K, Noguchi E, Ebihara T, Amagai M, Esaki H,
Takeuchi S, Furue M, Tamari M. Genetic polymorphism in the TRAF3IP2 gene is associated withpsoriasis vulgaris in a Japanese population. J Dermatol Sci 73(3):264-265, 2014
3. Iriguchi S, Kikuchi N, Kaneko S, Noguchi E, Morishima Y, Matsuyama M, Yoh K, Takahashi S,
Nakauchi H, Ishii Y. T-cell-restricted T-bet overexpression induces aberrant hematopoiesis of
myeloid

cells

and

impairsfunctionofmacrophages

in

the

lung.

Blood

doi:

10.1182/blood-2014-05-575225, 2014
4. Nanatsue K, Ninomiya T, Tsuchiya M, Tahara-Hanaoka S, Shibuya A, Masuko H, Sakamoto T,
Hizawa N, Arinami T, Noguchi E. Influence of MILR1 promoter polymorphism on expression levels
and the phenotype of atopy. J Hum Genet 59(9):480-483, 2014
5. Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N,
Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, Tran NB, Izutsu K, Sato Y,
Ohta Y, Furuta J, Shimizu S, Komeno T, Sato Y, Ito T, Noguchi M, Noguchi E, Sanada M, Chiba K,
Tanaka H, Suzukawa K, Nanmoku T, Hasegawa Y, Nureki O, Miyano S, Nakamura N, Takeuchi K,
Ogawa S, Chiba S. Somatic RHOA mutation in angioimmunoblastic T cell lymphoma. Nat Genet
46(2):171-175, 2014
6. Sic H, Kraus H, Madl J, Flittner KA, von Munchow AL, Pieper K, Rizzi M, Kienzler AK, Ayata K,
17

Rauer S, Kleuser B, Salzer U, Burger M, Zirlik K, Lougaris V, Plebani A, Romer W, Loeffler C,
Scaramuzza S, Villa A, Noguchi E, Grimbacher B, Eibel H. Sphingosine-1-phosphate receptors
control B-cell migration through signaling components associated with primary immunodeficiencies,
chronic lymphocytic leukemia, and multiple sclerosis. J Allergy Clin Immunol 134(2):420-428,
2014
7. Takayama K, Morisaki Y, Kuno S, Nagamoto Y, Harada K, Furukawa N, Ohtaka M, Nishimura K,
Imagawa K, Sakurai F, Tachibana M, Sumazaki R, Noguchi E, Nakanishi M, Hirata K, Kawabata K,
Mizuguchi H. Prediction of interindividual differences in hepatic functions and drug sensitivity byusing human iPS-derived hepatocytes. Proc Natl Acad Sci U S A 111(47):16772-16777, 2014
8. Tamari M, Saeki H, Hayashi M, Umezawa Y, Ito T, Fukuchi O, Nobeyama Y, Yanaba K, Nakagawa
H, Tsunemi Y, Kato T, Shibata S, Sugaya M, Sato S, Tada Y, Doi S, Miyatake A, Ebe K, Noguchi E,
Fujieda S, Ebihara T, Amagai M, Esaki H, Takeuchi S, Furue M, Hirota T. An association study of 36
psoriasis susceptibility loci for psoriasis vulgaris and atopic dermatitis in a Japanese population. J
Dermatol Sci 76(2):156-157, 2014
9. Tanaka Y, Manabe A, Fukushima H, Suzuki R, Nakadate H, Kondoh K, Nakamura K, Koh K,
Fukushima T, Tsuchida M, Koike K, Kiyokawa N, Noguchi E, Sumazaki R, Komiyama T. Multidrug
resistance protein 4 (MRP4) polymorphisms impact the 6-mercaptopurine dose tolerance during
maintenance therapy in Japanese childhood acute lymphoblastic leukemia. Pharmacogenomics J
doi: 10.1038/tpj.2014.74, 2014
10. Yatagai Y, Sakamoto T, Yamada H, Masuko H, Kaneko Y, Iijima H, Naito T, Noguchi E, Hirota T,
Tamari M, Konno S, Nishimura M, Hizawa N. Genomewide association study identifies HAS2 as anovel susceptibility gene for adult asthma in a Japanese population. Clin Exp Allergy
44(11):1327-1334, 20142) 英文以外の論文
1. 坂下雅文, 牧野友香, 野口恵美子, 広田朝光, 玉利真由美, 藤枝重治. アレルギー性鼻炎治療効
果に相関するバイオマーカー. アレルギー 63(6):767-774, 2014

分子遺伝疫学・社会健康医学
1) 英文論文
1. Chei CL, Yamagishi K, Ikeda A, Noda H, Maruyama M, Cui R, Imano H, Kiyama M, Kitamura A,
Asada T, Iso H. C-reactive protein levels and risk of disabling dementia with and without stroke inJapanese: the Circulatory Risk in Communities Study (CIRCS). Atherosclerosis 236(2):438-443,
18

2014
2. Cui R, Yamagishi K, Imano H, Ohira T, Tanigawa T, Hitsumoto S, Kiyama M, Okada T, Kitamura A,
Iso H. Relationship between the ankle-brachial index and the risk of coronary heart disease andstroke: the circulatory risk in communities study. J Atheroscler Thromb 21(12):1283-1289, 2014
3. Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda N, Sawanpanyalert
P, Patarapotikul J, Tsuchiya N, Ohashi J. A replication study confirms the association of
GWAS-identified SNPs at MICB and PLCE1 in Thai patients with dengue shock syndrome. BMC
Med Genet 15:58, 2014
4. Eshak ES, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Inoue M, Tsugane S. Riceconsumption is not associated with risk of cardiovascular disease morbidity or mortality in Japanese
men and women: a large population-based, prospective cohort study. Am J Clin Nutr
100(1):199-207, 2014
5. Eshak ES, Iso H, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Inoue M, Tsugane S.
Modification of the excess risk of coronary heart disease due to smoking by seafood/fish intake. Am
J Epidemiol 179(10):1173-1181, 2014
6. Fujita A, Ishibe N, Yoshihara T, Ohashi J, Makino H, Ikeda M, Setoguchi H. Rapid reversal ofneuromuscular blockade by sugammadex after continuous infusion of rocuronium in patients withliver dysfunction undergoing hepatic surgery. Acta Anaesthesiol Taiwan 52(2):54-58, 2014
7. Furukawa H, Kawasaki A, Oka S, Ito I, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N,
Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Amano H, Nagai T, Hirohata S, Setoguchi K,
Kono H, Okamoto A, Chiba N, Suematsu E, Katayama M, Migita K, Suda A, Ohno S, Hashimoto H,
Takasaki Y, Sumida T, Nagaoka S, Tsuchiya N, Tohma S. Human leukocyte antigens and systemic
lupus erythematosus: a protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03. PLoS One
9(2):e87792, 2014
8. Furukawa H, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K,
Suda A, Nagaoka S, Tsuchiya N, Tohma S. HLA-DRB1*08:02 Is Associated with
Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients. Biomark Insights
9:23-28, 2014
9. Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH, Tohma S, Alfredsson L, Okada Y, Xie G,
Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, Rodriguez-Rodriguez L, Chiocchia G,
Boileau C, Zhang J, Vittecoq O, Barnetche T, Gay MA, Furukawa H, Cantagrel A, Le Loet X,
Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoryati L,
Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieude P.
Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.
Ann Rheum Dis doi: 10.1136/annrheumdis-2013-204581, 2014
10. Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac NM, Hisaeda H, Matsuoka H,
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Kawai S, Endo H, Yasunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K. Generation ofrodent malaria parasites with a high mutation rate by destructing proofreading activity of DNApolymerase delta. DNA Res 21(4):439-446, 2014
11. Iso H, Imano H, Yamagishi K, Ohira T, Cui R, Noda H, Sato S, Kiyama M, Okada T, Hitsumoto S,
Tanigawa T, Kitamura A. Fasting and non-fasting triglycerides and risk of ischemic cardiovasculardisease in Japanese men and women: the Circulatory Risk in Communities Study (CIRCS).
Atherosclerosis 237(1):361-368, 2014
12. Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano
H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N,
Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H,
Sumida T, Tohma S, Tsuchiya N. Association of functional polymorphisms in interferon regulatory
factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.
PLoS One 9(10):e109764, 2014
13. Miyadera H, Ohashi J, Lernmark A, Kitamura T, Tokunaga K. Cell-surface MHC density profilingreveals instability of autoimmunity-associated HLA. J Clin Invest doi: 10.1172/JCI74961, 2014
14. Murakoshi N, Xu D, Sairenchi T, Igarashi M, Irie F, Tomizawa T, Tada H, Sekiguchi Y, Yamagishi
K, Iso H, Yamaguchi I, Ota H, Aonuma K. Prognostic impact of supraventricular prematurecomplexes in community-based health checkups: the Ibaraki Prefectural Health Study. Eur Heart J
doi: 10.1093/eurheartj/ehu407, 2014
15. Naka I, Patarapotikul J, Hananantachai H, Imai H, Ohashi J. Association of the endothelial protein
C receptor (PROCR) rs867186-G allele with protection from severe malaria. Malar J 13:105, 2014
16. Naka I, Patarapotikul J, Hananantachai H, Ohashi J. Lack of association between BSG
polymorphisms and cerebral malaria. Jpn J Infect Dis 67(6):432-435, 2014
17. Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N,
Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang
JH, Hige S, Ide T, Yamamoto K, Sakaida I, Murawaki Y, Itoh Y, Tamori A, Orito E, Hiasa Y, Honda
M, Kaneko S, Mita E, Suzuki K, Hino K, Tanaka E, Mochida S, Watanabe M, Eguchi Y, Masaki N,
Murata K, Korenaga M, Mawatari Y, Ohashi J, Kawashima M, Tokunaga K, Mizokami M. New
susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic
association study in Asia. PLoS One 9(2):e86449, 2014
18. Nishida W, Nagata M, Imagawa A, Hanafusa T, Ohashi J, Takahashi K, Suehiro T, Yamada Y, Chujo
D, Kawasaki E, Kawamura R, Onuma H, Osawa H, Makino H. Insulin administration may trigger
type 1 diabetes in Japanese type 2 diabetes patients with type 1 diabetes high-risk HLA class II and
the insulin gene VNTR genotype. J Clin Endocrinol Metab 99(9):E1793-1797, 2014
19. Ohashi J, Suzuki Y, Naka I, Hananantachai H, Patarapotikul J. Diversifying selection on thethrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum in Thailand.
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PLoS One 9(2):e90522, 2014
20. Oka S, Furukawa H, Kawasaki A, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Ito S,
Nakamura T, Saisho K, Katayama M, Tsunoda S, Sano H, Migita K, Suda A, Nagaoka S, Tsuchiya
N, Tohma S. Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis
patients. PLoS One 9(6):e99453, 2014
21. Sa-Ngasang A, Ohashi J, Naka I, Anantapreecha S, Sawanpanyalert P, Patarapotikul J. Associationof IL1B -31C/T and IL1RA variable number of an 86-bp tandem repeat with dengue shock syndromein Thailand. J Infect Dis 210(1):138-145, 201422. Sano F, Ohira T, Kitamura A, Imano H, Cui R, Kiyama M, Okada T, Yamagishi K, Sankai T,
Tanigawa T, Kario K, Iso H. Heavy alcohol consumption and risk of atrial fibrillation. The
Circulatory Risk in Communities Study (CIRCS). Circ J 78(4):955-961, 2014
23. Tsujimoto T, Sairenchi T, Iso H, Irie F, Yamagishi K, Watanabe H, Tanaka K, Muto T, Ota H. The
dose-response relationship between body mass index and the risk of incident stage >/=3 chronic
kidney disease in a general japanese population: the Ibaraki prefectural health study (IPHS). J
Epidemiol 24(6):444-451, 2014
24. Xu D, Murakoshi N, Sairenchi T, Irie F, Igarashi M, Nogami A, Tomizawa T, Yamaguchi I,
Yamagishi K, Iso H, Ota H, Aonuma K. Anemia and reduced kidney function as risk factors for new
onset of atrial fibrillation (from the Ibaraki prefectural health study). Am J Cardiol doi:
10.1016/j.amjcard.2014.10.041, 2014
25. Yamagishi K, Ikeda A, Moriyama Y, Chei CL, Noda H, Umesawa M, Cui R, Nagao M, Kitamura A,
Yamamoto Y, Asada T, Iso H. Serum coenzyme Q10 and risk of disabling dementia: the Circulatory
Risk in Communities Study (CIRCS). Atherosclerosis 237(2):400-403, 20142) 英文以外の論文
1. 佐野直樹, 田村孝史, 福永潔, 高野恵輔, 山岸良匡, 正田純一, 相川達也, 大河内信弘. 茨城県における肝細胞癌疫学調査. 肝臓 55(12):767-770, 20144) 英文以外の著書
1. 土屋尚之. 環境因子と遺伝因子; "ANCA 関連血管炎の診療ガイドライン（2014 年改訂版）”(編集 槇野博史, 松尾清一), 厚生労働省

難治性疾患克服研究事業 2014; pp10-14

2. 筑西市健康副読本編集委員. "筑西市健康副読本：めざせ！ず～っとけんこう！！ (第 8 版)”(編集 磯博康, 山岸良匡), 筑西市 (筑西) 2014; pp1-3021ゲノム生物学
1) 英文論文
1. Muratani M, Deng N, Ooi WF, Lin SJ, Xing M, Xu C, Qamra A, Tay ST, Malik S, Wu J, Lee MH,
Zhang S, Tan LL, Chua H, Wong WK, Ong HS, Ooi LL, Chow PK, Chan WH, Soo KC, Goh LK,
Rozen S, Teh BT, Yu Q, Ng HH, Tan P. Nanoscale chromatin profiling of gastric adenocarcinoma
reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. Nat
Commun 5:4361, 2014

再生幹細胞生物学
1) 英文論文
1. Zhao Y, Matsuo-Takasaki M, Tsuboi I, Kimura K, Salazar GT, Yamashita T, Ohneda O. Dualfunctions of hypoxia-inducible factor 1 alpha for the commitment of mouse embryonic stem cells
toward a neural lineage. Stem Cells Dev 23(18):2143-2155, 2014
2. Fukuda S, Ohneda O, and Oshika T. Oxidative stress retards vascular development before neuraldegeneration occurs in retinal degeneration rd1 mice. Graefes Arch Clin Exp Ophthalmol. 2014;
252:411-416.

医工学1) 英文論文
1. Miyoshi H, Morita M, Ohshima N, Sato C. Expansion of mouse hematopoietic progenitor cells inthree-dimensional cocultures on frozen-thawed stromal cell layers formed within porous scaffolds.
Exp Hematol doi:10.1016/j.exphem.2014.08.008, 2014

実験動物学1) 英文論文
1. Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A,
Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y. p38 Mitogen-activated protein kinase
accelerates emphysema in mouse model of chronic obstructive pulmonary disease. J Recept Signal

22

Transduct Res 34(4):299-306, 2014
2. Hasegawa Y, Daitoku Y, Mizuno S, Tanimoto Y, Mizuno-Iijima S, Matsuo M, Kajiwara N, Ema M,
Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K. Generation andcharacterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP
recombination. Exp Anim 63(2):183-191, 2014
3. Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T. Role ofretinoic acid and fibroblast growth factor 2 in neural differentiation from cynomolgus monkey(Macaca fascicularis) embryonic stem cells. Comp Med 64(2):140-147, 2014
4. Mizuno S, Dinh TT, Kato K, Mizuno-Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M,
Takahashi S, Sugiyama F, Yagami K. Simple generation of albino C57BL/6J mice with G291T
mutation in the tyrosinase gene by the CRISPR/Cas9 system. Mamm Genome 25(7-8):327-334,
2014
5. Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A. A mouse renin
distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice. J
Recept Signal Transduct Res 34(5):401-409, 20142) 英文以外の論文
1. 八神健一. CIOMS 動物実験に関する国際原則の改訂とその影響. 実験動物医学 43:40-44,
2014

医学物理学
1) 英文論文
1. Aihara T, Morita N, Kamitani N, Kumada H, Ono K, Hiratsuka J, Harada T. BNCT for advanced orrecurrent head and neck cancer. Appl Radiat Isot 88:12-15, 2014
2. Aoki-Nakano M, Furusawa Y, Uzawa A, Matsumoto Y, Hirayama R, Tsuruoka C, Ogino T, Nishio T,
Kagawa K, Murakami M, Kagiya G, Kume K, Hatashita M, Fukuda S, Yamamoto K, Fuji H,
Murayama S, Hata M, Sakae T, Matsumoto H. Relative biological effectiveness of therapeutic proton
beams for HSG cells at Japanese proton therapy facilities. J Radiat Res 55(4):812-815, 2014
3. Fujibuchi T, Yonai S, Yoshida M, Sakae T, Watanabe H, Abe Y, Itami J. Measurement of activity
distribution using photostimulable phosphor imaging plates in decommissioned 10 MV medical
linear accelerator. Health Phys 107(2 Suppl 2):S158-162, 2014
4. Fukumitsu N, Ishikawa H, Ohnishi K, Terunuma T, Mizumoto M, Numajiri H, Aihara T, Okumura T,
Tsuboi K, Sakae T, Sakurai H. Dose distribution resulting from changes in aeration of nasal cavity orparanasal sinus cancer in the proton therapy. Radiother Oncol 113(1):72-76, 201423

5. Fuse H, Suzuki K, Shida K, Mori Y, Takahashi H, Kobayashi D, Seki M, Isobe T, Okumura T, Sakae
T, Sakurai H. Total skin electron beam therapy using an inclinable couch on motorized table and acompensating filter. Rev Sci Instrum 85(6):064301, 2014
6. Horiguchi H, Sato T, Kumada H, Yamamoto T, Sakae T. Estimation of relative biologicaleffectiveness for boron neutron capture therapy using the PHITS code coupled with amicrodosimetric kinetic model. J Radiat Res doi: 10.1093/jrr/rru109, 2014
7. Kageji T, Mizobuchi Y, Nagahiro S, Nakagawa Y, Kumada H. Correlation between radiation doseand histopathological findings in patients with gliblastoma treated with boron neutron capture
therapy (BNCT). Appl Radiat Isot 88:20-22, 2014
8. Kageji T, Nagahiro S, Mizobuchi Y, Matsuzaki K, Nakagawa Y, Kumada H. Boron neutron capture
therapy (BNCT) for newly-diagnosed glioblastoma: comparison of clinical results obtained with
BNCT and conventional treatment. J Med Invest 61(3-4):254-263, 2014
9. Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka
K, Mori Y, Tsuboi K, Sakurai H. RBE and OER within the spread-out Bragg peak for proton beam
therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba. J Radiat
Res 55(5):1028-1032, 2014
10. Kumada H, Matsumura A, Sakurai H, Sakae T, Yoshioka M, Kobayashi H, Matsumoto H, Kiyanagi
Y, Shibata T, Nakashima H. Project for the development of the linac based NCT facility in Universityof Tsukuba. Appl Radiat Isot 88:211-215, 2014
11. Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E,
Tozawa A, Shoda J. Acceleration training for managing nonalcoholic fatty liver disease: a pilot study.
Ther Clin Risk Manag 10:925-936, 2014
12. Ohkawa A, Mizumoto M, Ishikawa H, Abei M, Fukuda K, Hashimoto T, Sakae T, Tsuboi K,
Okumura T, Sakurai H. Proton beam therapy for unresectable intrahepatic cholangiocarcinoma. J
Gastroenterol Hepatol doi: 10.1111/jgh.12843, 2014
13. Ohno T, Oshiro Y, Mizumoto M, Numajiri H, Ishikawa H, Okumura T, Terunuma T, Sakae T,
Sakurai H. Comparison of dose-volume histograms between proton beam and X-ray conformal
radiotherapy for locally advanced non-small-cell lung cancer. J Radiat Res . doi: 10.1093/jrr/rru082,
2014
14. Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M. Changes in diffusion tensor n
imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training. Magn Reson Imaging
32(10):1297-1300, 201415. Sato E, Yamamoto T, Shikano N, Ogura M, Nakai K, Yoshida F, Uemae Y, Takada T, Isobe T,
Matsumura A. Intracellular boron accumulation in CHO-K1 cells using amino acid transport control.
Appl Radiat Isot 88:99-103, 2014
16. Takada K, Kumada H, Isobe T, Terunuma T, Kamizawa S, Sakurai H, Sakae T, Matsumura A.
24

Whole-body dose evaluation with an adaptive treatment planning system for boron neutron capture
therapy. Radiat Prot Dosimetry doi: 10.1093/rpd/ncu357, 2014
17. Isobe T, Fujibuchi T, Takada K, Mori S, Kato H, Kasahara T, Sato E, Sakae T. Measurement ofdosedistribution during combined IVR procedure using the film method. Progress in Nuclear
Science and Technology 4:816-819, 2014
18. Takada K, Isobe T, Kumada H, Yamamoto T, Shida K, Kobayashi D, Mori Y, Sakurai H, Sakae T.
Evaluation of the radiation dose for whole body in boron neutron capture therapy. Progress in
Nuclear Science and Technology 4:820-823, 20142) 英文以外の論文
1. 粟飯原輝人, 熊田博明, 石川仁, 福光延吉, 奥村敏之, 大西かよ子, 水本斉志, 沼尻晴子, 田中圭
一, 和田哲郎, 原晃, 硲田猛真, 鈴木実, 櫻井英幸. 頭頸部がんに対するホウ素中性子捕捉療法の現状. 日本癌治療学会誌 49(3):2707, 2014
2. 粟飯原輝人, 森田倫正, 神谷伸彦, 熊田博明, 大西かよ子, 鈴木実, 平塚純一, 櫻井英幸, 原田保.
BNCT による頭頸部癌治療と頸動脈破裂症候群 BNCT を安全に行うために. 耳鼻咽喉科臨
床 補冊 補冊 139:143, 2014
3. 粟飯原輝人, 和田哲郎, 石川仁, 福光延吉, 奥村敏之, 大西かよ子, 水本斉志, 沼尻晴子, 熊田博
明, 平塚純一, 原晃, 櫻井英幸. 頭頸部進行がん新鮮例に対する新規粒子線治療の可能性 硼
素中性子捕捉療法に対する筑波大学の取り組みと今後の展望. 茨城県立病院医学雑誌30(2):28, 2014
4. 石田真也, 木村雅司, 佐藤勝, 宮本俊男, 吉村洋祐, 山梨宏一, 榮武二. 筑波大学における陽子線治療用 CT 値-水等価厚変換テーブルの作成. 日本放射線技術学会雑誌 70(9):974-975, 2014
5. 磯辺智範, 高田健太, 佐藤英介, 半村勝浩, 志田晃一, 松林史泰, 江川俊幸, 加藤英幸, 藤淵俊王,
笈田将皇, 千田浩一. 平成 24 年度学術調査研究班報告 放射線治療場で発生する二次中性子の簡易的評価システムの構築. 日本放射線技術学会雑誌 70(2):163-164, 2014
6. 岡本嘉一, 磯辺智範, 平野雄二. 【ROUTINE CLINICAL MRI 2015 BOOK】 骨格筋の MRI. 映
像情報 Medical 46(14):71-78, 2014
7. 熊田博明. 加速器ベース BNCT 治療装置の開発における PHITS 技術の適用. RIST NEWS56(14-24, 2014
8. 熊田博明. 次世代のがん放射線治療 BNCT の確立に向けて. CROSS

T&T 48:19-22, 2014

9. 熊田博明. 次世代がん放射線治療：BNCT の確立に向けて. 長瀬ランダウア「NL だより」
440(8):1, 2014
10. 虎口大介, 布施拓, 藤崎達也, 猪平将也, 今泉美優, 神戸勇汰, 平谷尚暉. 陽子線治療における体内金属の検討. 日本放射線技術学会雑誌 70(9):1017, 2014
11. 櫻井英幸, 石川仁, 福光延吉, 粟飯原輝人, 大西かよ子, 水本斉志, 室伏景子, 沼尻晴子, 大城佳子, 林靖孝, 奥村敏之, 榮武二, 坪井康次. 【外科切除適応の境界領域-Borderline resectable25

cancer への対応】 診断/術前療法 難治性腫瘍における術前(化学)放射線治療の意義 外科をサポートするための周術期放射線治療を目指して. 臨床外科 69(12):1310-1314, 201412. 志田隆史, 小野塚太郎, 呉世昶, 上牧隆, 磯辺智範, 岡本嘉一, 矢藤繁, 島野仁, 正田純一. 肥満と 糖 尿 病 が 肝 脂 肪 化 と 線 維 化 に 及 す 影 響 と 病 態 関 連 因 子 の 解 析. 超 音 波 医 学
41(Suppl.):S598, 201413. 志田隆史, 小野塚太郎, 呉世昶, 磯辺智範, 岡本嘉一, 矢藤繁, 島野仁, 正田純一. 非アルコー
ル性脂肪性肝疾患における中高度肥満と糖尿病が肝病態に及す影響と病態関連因子の解析. 肝臓 55(Suppl.1):A450, 201414. 高田健太, 高橋昭久, 佐藤英介, 飯森隆志, 笈田将皇, 千田浩一, 磯辺智範. 班報告

温熱療法における効率的な加温技術の構築. 日本放射線技術学会雑誌 70(9):1019, 201415. 田中圭一, 粟飯原輝人, 熊田博明, 福光延吉, 奥村敏之, 石川仁, 大西かよ子, 水本斉志, 沼尻
晴子, 和田哲郎, 原晃, 硲田猛真, 鈴木実, 櫻井英幸. 筑波大学における BNCT 臨床研究再開計画について. 頭頸部癌 40(2):225, 2014
16. 布施拓, 榮武二, 照沼利之, 神澤聡, 瀬川達矢, 吉村洋祐, 山梨宏一, 佐藤勝, 櫻井英幸. 陽子線治療装置におけるアイソセンタ検証ツールの使用経験. 医学物理 33(4):166-170, 2014
17. 山梨宏一, 熊田博明, 高田健太, 小滝幸平, 纐纈純一, 榮武二. BNCT 治療計画システムの線量計算に使用するヒストリ数の検証. 日本放射線技術学会雑誌 70(9):969, 20143) 英文著書
1. Kumada H. Volume 8. Section 8.13 Nuetron Source; in "Comprehensive Biomedical Physics (1stedition)" (edited by Brahme A et al), Elsevier B.V (Netherlands) 2014; pp197-217
2. Sakurai H, Okumura T, Fukumitsu N, Ishikawa H, Ohnishi K, Mizumoto M, Terunuma T, Kumada
H, Sakae T. 7. Proton Beam Therapy for Hepatocellular Carcinoma; in "Thearapy for Hepatocellular
Carcinoma Etiology and Treatment (1st edition)" (edited by Ohkohchi N), Nova Science Publishers(New York) 2014; pp243-308
4) 英文以外の著書
1. 磯辺智範. 若葉マークの画像解剖学. メディカルビュー社 (東京) 2014 年 (全 650 ページ)
2. "臨床工学技士 グリーン・ノート 基礎編 (第 1 版)” (企画協力 磯辺智範), メディカルビュー
社 (東京) 2014 年
3. "臨床工学技士 グリーン・ノート 臨床編 (第 1 版)” (企画協力 磯辺智範), メディカルビュー
社 (東京) 2014 年
4. 熊田博明. 第Ⅳ分冊. 3 章

放射線利用・研究炉 3.2.5BNCT 用ビームの取出し、照射設備; "原子力・量子・核融合事典 (全Ⅵ分冊)” (編集 工藤和彦、他), 丸善出版 (東京) 2014; pp138-13926

放射線生物学
1) 英文論文
1. Fukumitsu N, Ishikawa H, Ohnishi K, Terunuma T, Mizumoto M, Numajiri H, Aihara T, Okumura T,
Tsuboi K, Sakae T, Sakurai H. Dose distribution resulting from changes in aeration of nasal cavity orparanasal sinus cancer in the proton therapy. Radiother Oncol 113(1):72-76, 2014
2. Kanemoto A, Hirayama R, Moritake T, Furusawa Y, Sun L, Sakae T, Kuno A, Terunuma T, Yasuoka
K, Mori Y, Tsuboi K, Sakurai H. RBE and OER within the spread-out Bragg peak for proton beam
therapy: in vitro study at the Proton Medical Research Center at the University of Tsukuba. J Radiat
Res 55(5):1028-1032, 2014
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green 15 min after administration and life prognosis in patients with HCC treated by proton beam
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Okumura T, Sakurai H. Proton beam therapy for unresectable intrahepatic cholangiocarcinoma. J
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6. Sun L, Mizuno Y, Iwamoto M, Goto T, Koguchi Y, Miyamoto Y, Tsuboi K, Chida K, Moritake T.
Direct measurement of a patient's entrance skin dose during pediatric cardiac catheterization. J
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pathway may play a major role in high-LET radiation-induced DNA double-strand break repair. J
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1. 櫻井英幸, 石川仁, 福光延吉, 粟飯原輝人, 大西かよ子, 水本斉志, 室伏景子, 沼尻晴子, 大城佳子, 林靖孝, 奥村敏之, 榮武二, 坪井康次. 【外科切除適応の境界領域-Borderline resectable
cancer への対応】 診断/術前療法 難治性腫瘍における術前(化学)放射線治療の意義 外科をサポートするための周術期放射線治療を目指して. 臨床外科 69(12):1310-1314, 2014
2. 福光延吉, 奥村敏之, 石川仁, 大西かよ子, 水本斉志, 沼尻晴子, 坪井康次, 櫻井英幸. 【肝がん:診断と治療の進歩】 治療法の進歩 肝がんの放射線治療. 日本内科学会雑誌 103(1):116-122,201427

生命反応化学
1) 英文論文
1. Akiba H, Sumaoka J, Hamakubo T, Komiyama M. Conjugation-free, visual, and quantitativeevaluation of inhibitors on protein tyrosine kinases and phosphatases with a luminescent Tb(III)complex. Anal Bioanal Chem 406(12):2957-2964, 2014
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4. Sumaoka J, Komiyama M. Molecular Crowding Facilitates Double-duplex Invasion of
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click chemistry: A protective structure for telomere end. Bioorg. Med. Chem. 22(16):4419-4421,
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7. Yamazaki T, Heddle JG, Kuzuya A, Komiyama M. Orthogonal enzyme arrays on a DNA origami
scaffold bearing size-tunable wells. Nanoscale 6(15):9122-9126, 2014

環境生物学1) 英文論文
1. Abiko Y, Mizokawa M, Kumagai Y. Activation of the Kelch-like ECH-associated protein 1(Keap1)/NF-E2-related factor 2 (Nrf2) pathway through covalent modification of the 2-alkenal
group of aliphatic electrophiles in Coriandrum sativum L. J Agric Food Chem 62(45):10936-10944,
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Identification and quantification of in vivo metabolites of 9,10-phenanthrenequinone in human urine
associated with producing reactive oxygen species. Chem Res Toxicol 27(1):76-85, 2014
3. Contu VR, Kotake Y, Toyama T, Okuda K, Miyara M, Sakamoto S, Samizo S, Sanoh S, Kumagai Y,
Ohta S. Endogenous neurotoxic dopamine derivative covalently binds to Parkinson's
28disease-associated ubiquitin C-terminal hydrolase L1 and alters its structure and function. J
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4. Fujiwara Y, Yamamoto C, Yoshida E, Kumagai Y, Kaji T. Heparan sulfate chains potentiate cadmium
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5. Hagiya Y, Kamata S, Mitsuoka S, Okada N, Yoshida S, Yamamoto J, Ohkubo R, Abiko Y, Yamada H,
Akahoshi N, Kasahara T, Kumagai Y, Ishii I. Hemizygosity of transsulfuration genes confers
increased vulnerability against acetaminophen-induced hepatotoxicity in mice. Toxicol Appl
Pharmacoldoi: 10.1016/j.taap.2014.11.015, 2014
6. Ida T, Sawa T, Ihara H, Tsuchiya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S,
Matsunaga T, Yamamoto M, Ono K, Devarie-Baez NO, Xian M, Fukuto JM, Akaike T. Reactive
cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling. Proc Natl
Acad Sci U S A 111(21):7606-7611, 2014
7. Kanda H, Shinkai Y, Kumagai Y. S-mercuration of cellular proteins by methylmercury and its
toxicological implications. J Toxicol Sci 39(5):687-700, 2014
8. Makino K, Okuda K, Sugino E, Nishiya T, Toyama T, Iwawaki T, Fujimura M, Kumagai Y, Uehara T.
Correlation between attenuation of protein disulfide isomerase activity through S-mercuration andneurotoxicity induced by methylmercury. Neurotox Resdoi: 10.1007/s12640-014-9494-8, 2014
9. Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J,
Fukuto JM. Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species:
implications of their possible biological activity and utility. Free Radic Biol Med 77:82-94, 2014
10. Toyama T, Shinkai Y, Yazawa A, Kakehashi H, Kaji T, Kumagai Y. Glutathione-mediatedreversibility of covalent modification of ubiquitin carboxyl-terminal hydrolase L1 by
1,2-naphthoquinone through Cys152, but not Lys4. Chem Biol Interact 214:41-48, 2014
11. Yoshida E, Abiko Y, Kumagai Y. Glutathione adduct of methylmercury activates the Keap1-Nrf2
pathway in SH-SY5Y cells. Chem Res Toxicol 27(10):1780-1786, 20142) 英文以外の論文
1. Fujie T, Naka H, Yamamoto C, Shinkai Y, Kumagai Y, Kaji T. Activation of cellular defense
mechanism by organic-inorganic hybrid molecules. Yakugaku Zasshi 134(7):813-5, 2014
2. Nishida M, Toyama T, Kumagai Y, Numaga-Tomita T. Establishment of a novel therapeutic strategy
for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive
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1. 熊谷嘉人. 19. 活性酸素による化学修飾とセンサータンパク質; "酸化ストレスの医学 (改訂29第 2 版)” (監修 吉川敏一, 編集 内藤裕二, 豊國伸哉), 診断と治療社 (東京) 2014; pp154-160
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環境分子生物学
1) 英文論文
1. Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H,
Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N,
Suematsu E, Ohno S, Katayama M, Okamoto A, Kono H, Tokunaga K, Takasaki Y, Hashimoto H,
Sumida T, Tohma S, Tsuchiya N. Association of functional polymorphisms in interferon regulatory
factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: a case-control association study.
PLoS One 9(10):e109764, 2014
2. Kurosawa M, Matsumoto G, Kino Y, Okuno M, Kurosawa-Yamada M, Washizu C, Taniguchi H,
Nakaso K, Yanagawa T, Warabi E, Shimogori T, Sakurai T, Hattori N, Nukina N. Depletion of p62
reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model
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3. Seto K, Shoda J, Horibe T, Warabi E, Kohno M, Yanagawa T, Bukawa H, Nakanuma Y, Kawakami
K. Targeting interleukin-4 receptor alpha by hybrid Peptide for novel biliary tract cancer therapy. Int
J Hepatol 2014:584650, 2014
4. Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, Mori F, Warabi E, Yanagawa T, Ueno
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Pathol doi: 10.1111/bpa.12214, 20142) 英文以外の論文
1. 蕨栄治. p62/Sequestosomel の生理機能. 生化学 86(6):783-787, 2014

環境微生物学1) 英文論文
1. Konishi M, Ohkura T, Shimizu M, Akiyama M, Kameyama K, Takeuchi K. Complete genome
sequence of the first isolate of genotype C bovine parainfluenza virus type 3 in Japan. Genome
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2. Ohkura T, Minakuchi M, Sagai M, Kokuho T, Konishi M, Kameyama K, Takeuchi K. Infection of the30

upper respiratory tract of hamsters by the bovine parainfluenza virus type 3 BN-1 strain expressing
enhanced green fluorescent protein. Virology doi: 10.1016/j.virol.2014.12.015, 2014
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4. Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K,
Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J. Expression of
N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival ofpathological tumor stage 2 carcinoma of the gallbladder. J Gastroenterol 49(4):702-714, 2014
5. Oshiro Y, Yasue H, Takahashi K, Hattori S, Ideno S, Urayama T, Chiba M, Osari S, Naito T, Takeuchi
K, Nagata K, Ohkohchi N. Mode of swine hepatitis E virus infection and replication in primary
human hepatocytes. J Gen Virol 95(Pt 12):2677-2682, 2014
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frequently in a gene inserted into the IC323 recombinant measles virus during its persistence in thebrains of nude mice. Virology 462-463:91-97, 2014

分子発生生物学
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1. 田中佐代子, 小林麻己人, 三輪佳宏. ｢科学者のためのビジュアルデザインハンドブック｣の有用性と問題点. 芸術研究報 34:35-46, 2014

環境保健学（産業精神医学・宇宙医学）
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1. Doki S, Sasahara S, Matsuzaki I. Psychological approach of occupational health service to sick leave
due to mental problems: a systematic review and meta-analysis. Int Arch Occup Environ Healthdoi: 10.1007/s00420-014-0996-8, 2014
2. Doki S, Sasahara S, Suzuki S, Hirai Y, Matsuzaki I. Health habits and stress coping among japanese
local government workers: A cross-sectional study. Journal of physical fitness nutrition andimmunology 24(2):64-69, 2014
3. Hirai Y, Kobayashi N, Oi Y, Usami K, Sasahara S, Matsuzaki I. Changes of readiness to return towork of users’ in a japanese social firm: a longitudinal study. Journal of physical fitness nutrition
and immunology 24(2):70-78, 2014312) 英文以外の論文
1. 平井康仁, 小林直紀, 友常祐介, 関昭宏, 大井雄一, 宇佐見和哉, 笹原信一朗, 松崎一葉. 心の健
康問題による休業者の復職支援:事業規模別の事業場外資源に対する認知について. 体力・栄養・免疫学雑誌 24(2):90-98, 2014
2. 平井康仁, 鈴木瞬, 道喜将太郎, 金子秀敏, 小林直紀, 関昭宏, 商真哲, 羽岡健史, 大井雄一, 梅
田忠敬, 宇佐見和哉, 友常祐介, 吉野聡, 笹原信一朗, 松崎一葉. 筑波研究学園都市の労働者を対象とした主観的健康感の実態調査. 厚生の指標 61(2):22-28, 20144) 英文以外の著書
1. 宇佐見和哉. 事例でなっとく! 精神科産業医が教える 障害年金請求に必要な精神障害の知
識と具体的対応. 日本法令 2014 年 (全 273 ページ)32