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AnniversarythLooking Back at
the FHS International Conference

Faculty of Health Sciences,
Hokkaido University

A special dedication to Prof. Hiroyuki Date
On August 7, 2022, we were saddened and devastated by the news of thesudden passing of Professor Hiroyuki Date. He was the Dean of the Facultyof Health Sciences and also the President of the 1st, 2nd and 5th Hokkaido
University Faculty of Health Sciences (FHS) Conference. He was also inline to be the President of the 6th FHS Conference in 2023.

In recognition of his hard work, dedication and positivity, we dedicate thismemorialbook to the late Professor Date.

Taro Yamauchi

Chair of FHS International Conference
Professor, Director of the International Affairs Office
Faculty of Health Sciences, Hokkaido University

Preface
The 1st conference was held in July 2013, and we invited speakers from our two partner universities:
Diponegoro University in Indonesia and Taipei Medical University in Taiwan. From the second FHS onwards,
the conference featured graduate students’ poster presentations to provide them with a special opportunity togive a presentation at an international conference. At the conference meeting, we welcomed more international
speakers from our partner universities than the number of speakers from the host, Hokkaido University.
Because of the COVID-19 pandemic, the dates for the 5th FHS conference in 2021 were moved to September
from July; the whole conference was held online over two days. Next year, 2023, will mark the 10th anniversaryof FHS. We cannot wait to hold the conference face-to-face this time around.
This memorial book consists of four parts: (1) Memories shared by the former FHS presidents, the chair and thedelegates from our five partner universities; (2) Programs and abstracts of the invited lectures; (3) Best poster
presentation awards for graduate students; (4) Data on presenter demographics (host/invited speakers andgraduate students) and the frequent keywords extracted from the abstract/poster presentation titles. I hope you
all enjoy looking back at a decade of fond memories from the FHS International Conferences.
In the next 10 years, I hope that more graduate students will join FHS and we will have international
conferences hosted by our partner universities to further deepen the bond between us and extend international
collaboration. To conclude, I’d like to express my sincere gratitude to all the members who have been involved
in FHS conferences including former chairs, invited speakers, graduate students and organizing committee
members for their dedication.
Sapporo, Japan
Taro Yamauchi

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FHS International Conferences

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Memor
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1st

Date
Venue
Theme

July 5, 2013
School of Medicine, Hokkaido University
Evolving Health Sciences in Asia

2nd

Date
Venue
Theme

July 3, 2015
Faculty of Health Sciences, Hokkaido University
Gazing into the Future of Health Sciences in Asia

3rd

Date
Venue
Theme

July 7, 2017
Faculty of Health Sciences, Hokkaido University
Hitch our wagon to a remedy!

4th

Date
Venue
Theme

July 5, 2019
Faculty of Health Sciences, Hokkaido University
Putting the Pieces Together: Creating A New Era of Health Sciences in Asia

5th

Date
Venue
Theme

September 17–18, 2021
Online via Zoom & SlackLook for the Silver Lining in the Post-Pandemic Health Sciences

The former FHS presidents, the chair,and the delegates from our five partner universities

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Looking Back at the FHS International Conference— Message to Young Researchers —Professor Hiroyuki Date
Faculty of Health Sciences, Hokkaido University, Sapporo, JapanThe first Faculty of Health Science (FHS)International Conference was held in 2013 aiming
for promoting the research activities of youngteaching staff and graduate students in alliancewith researchers in other countries. Since the firstmeeting, FHS has been convened every other year.
Here, looking back at the past and present of this
precious event, I am deeply moved by recognizingthat the field of health sciences develops steadily
through efforts of the participants (particularly
young researchers). I would like to express myrespect for their contributions to this field of study.
Before the first FHS (July 5, 2013), our instituteconcluded agreements with Diponegoro University(Faculty of Medicine) and Dr Kariadi Hospitalin Indonesia (Dec. 2012) and Taipei Medical
University (College of Medicine, College of Nursing,
College of Public Health and Nutrition, College ofMedical Science and Technology) in Taiwan (Dec.
2012). Accordingly, we had many guests fromthese institutes and had very good time with themin the first FHS.
In 2015, the second FHS was held (July 3)
just after the conclusion of agreements with
Chulalongkorn University (Faculty of Medicine)in Thailand (Jun. 2015) and Kaohsiung Medical
University (College of Health Sciences) in Taiwan(Jun. 2015). Also in this time, the informational
exchange was actively conducted among graduate
students and guests from the above countries.
At the third FHS in 2017 (July 7), the numberof participants surpassed 250 (much larger than
140 in the second FHS). Ten invited speakers fromhome and abroad gave their lectures, and there
were 76 entries to the poster presentation session.
In 2019 the fourth FHS was held (July 5)following the conclusion of agreements with

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Chulalongkorn University (The Faculty of Allied
Sciences) in Thailand (Aug. 2018) and Universityof Hong Kong (School of Nursing) in China (Jan.
2019). The number of participants was over 270.
Twelve speakers from home and abroad provided
their talks, and 77 poster presentations by
graduate students were in bustle with activity.
The fifth FHS was held in 2021 (September
17–18), which experienced an online conference
for the first time due to “COVID-19 pandemic”.
Despite in the unaccustomed situation,
participants enjoyed the discussions and 85 poster
presentations remotely for two days.
In recent years, medical sciences and heathcare have been directed to a broad range ofsubjects, such as transplant and regeneration
medicines, gene therapy, measures against
infectious disease and life-style disease, provision
for an aging society, and so on. In light of thesesubjects, “Health Sciences” forms an academic areaemphasizing health maintenance, the prediction
and protection against diseases, rehabilitation after
medical treatment and handling of senile changes,
in addition to conventional medical issues. We
therefore have to construct urgently a platform forsupporting the health care system in order to live
long and healthy lives.
Many countries of the world have witnessed
great changes in the natural environment andsocial circumstances. For example, infectious
diseases have brought threats several times not
only to a specific area but also to an extensive area
over the world. On the other hand, high speed
global communication is common, and we cantake a close look at almost any geographical area
by satellite images. There are also the changes in
the urban environment and transit system, anddemographic changes arising from the declining
birth rate and the growing population of elderly
people in rural areas.
In present-day Japan, we are doing well,free from the lack of food and clothing, andwe can justly assert our freedom, equality andhuman rights. I suppose this is quite a rare statehistorically. However, new problems are emerging
in the period after World War II, such as a lack of asense of identity, spiritual ambiguity and life-style
related diseases caused by Western dietary habits(such as obesity and hyper-tension). Although all
may seem peaceful on the surface, our incapabilityof crisis management for sudden disasters andpandemic of infectious diseases, and the problemof economic standstill are causing all of us anxiety.
The problems above must be faced by theyounger generations. This is why I would like tosay to young people to partake in the FHS andto communicate with the investigators in othercountries. You must be tackling your own researchsubject in the master or doctor course, envisaging
the problems that need to be overcome and thescientific truth that should be explored in the
future; and at the same time, you must be awareof the concernment for avoiding dogmatism andpedanticism.
A long time ago, in the Roman times, someone
said “Life is short, but artifice is long”. That is,
our life span is too short to attain a universal
and comprehensive scheme of things. Therefore,
essential knowledge and cutting-edge technology
should be ceaselessly passed on to the next
generation. All the more because of this, I hopethat you keep your sense of inquiry in mind
and proceed on to a higher step of professional
specialty.
At last, but not the least, I would like tostrongly recommend that you think a great deal ofconnections with your friends abroad and faculty
members because these connections will lead tofruitful relationships and offer mental and spiritualsustenance for the rest of your life.
I hope for your bright and successful future
along with the FHS International Conference!

Professor Date’s
opening remarks inthe 5th FHS in 2021

Poter session of the
2nd FHS in 2015

Group photo of
the 1st FHS in
2013

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Looking toward the Future— A Decade of Memories from FHS —Professor Emeritus Takeshi Saito

Professor Taro Yamauchi

Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Congratulations on the 10th Anniversary of the
FHS International Conference!
Continuity is the father of success, and I believethat FHS’ 10-year journey has proven just that. I
would like to express deep respect to the faculty
members and students of the Faculty of Health
Sciences who have supported the FHS International
Conference for the past 10 years and who arelooking forward to its further development.
Today’s society is facing increasing socialand environmental problems on a global scale,making it difficult for people to live healthy
lives. The time has come for health sciences tocontribute to society by promoting and extending
physical and mental health, preventing disease
and rehabilitating people from disease, but there
are few international conferences that coversuch a wide range of health science fields. The
Faculty of Health Sciences of Hokkaido University
consists of six specialized health science fields.
The significance of the existence of the FHS
International Conference is that faculty andgraduate students from all of these specialties
can participate in the conference where theycan engage in broad and deep discussions withhealth science researchers from around the world,
especially from Asia.
I was involved in the organization of the 4th

Welcome receptionof the 4th FHS in
2019

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Let’s Create a New Era of
Health Science in Asia!

FHS International Conference as one of the staff
members in 2019 when I was the Dean of theFaculty of Health Sciences. We hoped that the
4th FHS International Conference would be aninternational conference that will lead to thefurther development of health sciences while
keeping alive the past trends of FHS, and we have
set the main theme as “Putting the Pieces Together:
Creating A New Era of Health Sciences in Asia”.
We organized three symposiums and two poster
sessions and invited researchers in the fields ofNursing, Biomedical Science and Engineering,
Medical Laboratory Science, Rehabilitation Science,
Health Sciences and Technology from Taiwan,
Korea, Thailand, China and Japan as invited
speakers. The poster presentations by graduate
students from various countries exceeded 70,
making it a very active conference.
We hope that graduate students who haveattended or will attend the FHS International
Conference will take advantage of this opportunity
to reflect on the interdisciplinary significanceof their research, and become health science
researchers and educators who will collaborate
with researchers around the world in the future.
I hope that the FHS International Conference
will continue to grow and develop over the next
10 to 20 years.

My name is Taro Yamauchi, and I am the Chair of
the FHS International Conference. The Conference
was founded by the late Professor Hiroyuki Dateand me. Professor Date was the President of the 1st
FHS International Conference. Honestly speaking, I
never imagined the conference would continue for10 years after its 2013 inauguration. I would like totake this opportunity to extend a huge thank you toeveryone involved: our partner universities, invited
speakers, graduate students that took part in, andabove all, the members of the International Affairs
Office who have immensely supported FHS as theorganizing committee.
From the second FHS onwards, we featured
graduate students’ poster presentations to provide
students with a special opportunity to give a
presentation at an international conference. During
the one-minute “shotgun presentation” sessionthat took place right before the poster session,some students faced the unexpected or technicalissues which happened to make the session oneof the most exciting, fun and lesson-to-learn
moments. It also offered the students a great
opportunity to give a summary talk in English on
their research. Over the course of years, so many
more people started participating in the gatherings
that the FHS has become one of the official eventsof Hokkaido University’s Faculty and Graduate
School of Health Sciences.
As you would recall, FHS was always held in
early July around the Star Festival time in Japan. I
reckon Sapporo in early summer is one of the best
and most pleasant places to be in the world. Our
overseas guests may agree with me since they all
loved the weather. At the welcome dinner party forour guests held before each conference, we treatedourselves to the tastes of Hokkaido and Japan suchas sushi. Meanwhile, students enjoyed socializing
with our guests from abroad atthe after party. I get
reminded of good old memories like setting up the
party venue with other committee members within
an hour right after the conference, announcing thebest poster presentation award winners during theparty and signing a large conference banner withall attendees after each conference.
Because of the COVID-19 pandemic, the 5th FHS
in 2021 was moved to September from the Star
Festival season. We hoped the pandemic to end
quickly, but the situation seemed to be worsened.
We once considered postponing the event, but
the organizing committee discussed and resolved
to hold the whole conference online. Thanks toeveryone’s effort to get it underway, the first online
conference was a big success. The participants andI nevertheless felt there was something missing in
the online event, like chatting or discussing topics
face-to-face and enjoying a meal together.
The organizing committee is planning to holdthe 6th FHS in 2023 which shall commemorateits 10th anniversary. I am truly looking forward
to reuniting with my good old friends from thepartner universities, and more graduate students
to participate in the FHS programs. And I have astrong hope that our partner universities will hostinternational conferences in the coming years
when we are not having an FHS meeting.
To conclude, I would like to say we shall looktoward the future of health sciences in honor ofProfessor Date who was to be the President of
the 6th FHS next year. His warm and loving smile
remains with us and his words will keep inspiring
graduate students and early career researchers.
I very much look forward to seeing you all in
Sapporo in 2023.

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SAKURA Exchange
Program in 2016

FHS Memories
Dr. Maria Mexitalia
Faculty of Medicine, Diponegoro University / Dr. Kariadi Hospital, Semarang, Indonesia

Poster presentation in theafternoon section. Shortterm exchange student from
Taipei Medical University.
Ms. Miho Aiba, Mr. Shao-Yu
Chao, Mr. Wei-Ting Li and Dr.
Chia-Hwa Lee

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Dr. Handoyo and Dr.
Mexitalia, in the 1st
FHS in 2013

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Hokkaido University, as well as colleagues fromsome countries in Asia.
We also had opportunity to visit many
interesting places in Sapporo and nearby townsuch Otaru. FHS is held in July, early mild summer,
when the weather is very pleasant in Hokkaido.
Japanese food is very delicious. Although there aremany Japanese restaurants in Indonesia, the tasteof authentic Hokkaido food is still the best. Even
though I’m not a beer drinker, but Sapporo beer
is so good that I can enjoy to drink it. The beer isslightly sweet start and super clean finish. I cannot
forget the taste of Sapporo ramen and Otaru’s
crabs. It was very tasty and distinctive.
In 2021, I am attending the online 5th
FHS International Conference. Of course theatmosphere is very different. Unfortunately,
foreign students cannot be participated in freepapers session. Maybe it’s good for future events,
the FHS can be held as hybrid conference, and thestudents from other countries get the opportunity
to present on the free paper session.
I attach some memorable photos from First FHS
and Second FHS, as well as the SAKURA Exchange
Program. Hopefully we can meet again in Sapporo
in the near future.

From

My name is Maria Mexitalia. I am a pediatrician
from the Faculty of Medicine Diponegoro
University / Dr. Kariadi Hospital. I was invited as aspeaker at the First and Second FHS International
Conference in 2013 and 2015. In 2016 I was also
invited as a speaker at the “Japan-Asia YouthExchange Program in Science (SAKURA Exchange
Program in Science)” organized by the Faculty of
Health Sciences Hokkaido University.
My topic at the First FHS was about “Nonalcoholic fatty liver disease (NALFD) and metabolic
syndrome of Indonesian obese adolescents in
Semarang”. In addition, I also introduced the profile
of our institution to the audience. On the Second
FHS 2015, I talked about “Early life nutrition,from breastfeeding to complementary feeding”.
And at the SAKURA Exchange Program 2018 mypresentation was about “The physical activity andexercise of Indonesian children in correlation withnutritional status”.
It was very valuable experience for me andcolleagues from Indonesia to join the conference,
because we can exchange ideas, and discussresearch or other activities in scientific sessions.
Besides, we were invited to a warm dinner withcolleagues from the Faculty of Health Sciences

Memories of Hokkaido University
and the FHS International Conference
Dr. Chia-Hwa Lee
Taipei Medical University, Taipei, Taiwan

For many Taiwanese, Japan is always
considered the most attractive and friendly
country in the world. For myself, I have traveled
to several big cities including Tokyo, Kyoto,
and Osaka for more than 5 times in the past.
However, before I visited Hokkaido, it remained
a mysterious place for me, and I tried to findappropriate opportunities to visit.
For years, the international exchange program
between the Departments of Medical Laboratory
Sciences in Hokkaido University and in Taipei

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Medical University has benefitted many students.
Therefore, I volunteered to join this exchange
program in the summer vacation in 2019. I
took this opportunity to be a visiting scholar
in the Faculty of Health Sciences, at Hokkaido
University. I was arranged to visit the CardiographSpecialized Lab, led by Dr. Sanae Kaga. Dr. Kaga isan outstanding expert in the sonograph researchof cardiovascular. She is also an authorized
ultrasonographer (circulatory organ emphasis) by
the Japan Medical Ultrasonics Organization, and

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various types of breast, thyroid and leukemia
cancers. Back to the year 2019, CRISPR-Cas9 wasstill a very novel technology and was waiting to be
explored and applied in anti-cancer therapy. Afterthe speech, I received many precious feedbacks
and comments that greatly promoted my research
quality. In the afternoon of the FHS International
Conference, a poster session was arranged. The
students/authors were required to provide a
one-minute shotgun presentation before theposter presentation. I think this was a very goodtraining for students to summarize and conclude
their own study from the audience’s perspective
and to present it in a very limited time. Although
the FHS International Conference covered many
fields in human health sciences I could not fully
understand, I noticed that many participants orstudents came from South-East Asia countries,
which again proves that Hokkaido University is
indeed an international academic institute. In
addition, a significantly high percentage of studies
were related to improving the environmental
conditions or health cares in undeveloped ordeveloping countries. As a citizen of the world,
I admired the courage and ambition of every
member in Hokkaido University, who all came
together to promote human welfare and makethe world better. After coming back to Taiwan, I
particularly like the well-known phrase and mottoof Hokkaido University, said by Dr. William Smith
Clark, the first principal of Sapporo Agricultural
College (The former name of Hokkaido University)— “Boys, be ambitious!”Fromby the Graphics Organization Specialist in Japan aswell. During my stay in the Echocardiography Lab,I learned extra knowledge and skills to interpretthe clinical symptoms or follow-up interpretationsof heart diseases. I am specially thankful to Dr.
Kaga for giving me an opportunity to learn not
only the skills in echocardiography, but also toadopt a rigorous and professional research attitude
toward being an echocardiographic specialist.
During the visit, I was honored to give a speechin the 4th FHS International Conference. I still
remember one night before the conference, I
attended the welcome reception with a delicacy
banquet. I met many great scientists who haveexpertise in different fields of human healthscience. Unexpectedly, I met another invited
speaker, Dr. Yeou-Lih Huang, who is a Professor
in the Department of Medical Laboratory Scienceand Biotechnology, Kaohsiung Medical University,
Taiwan. During the conference, Dr. Yeou-Lih Huang
and I, together with other experts, including Dr.
Shu-ping Hui, and Dr. Yamaguchi from Medical
Laboratory Sciences in Hokkaido University,
had many scientific discussions and had many
opportunities to exchange our academic ideas. We
enjoyed the banquet very much.
The whole-day FHS program contained three
symposiums. I was arranged to give a speech in thefirst session in the morning. My speech title was“The applications and advances of CRISPR-Cas9 on
cancer research and therapy”, which summarized
my main studies about the CRISPR mechanism
and its potential applications on fighting against

Memories of Faculty of Health Sciences,
Hokkaido University
Professor Anchali Krisanachinda
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

Upon the Notation for Student Exchanges
between Faculty of Medicine, Chulalongkorn
University and the Graduate School of Health
Sciences, Hokkaido University, on the basis ofagreement for international academic exchanges
concluded on June 3, 2015. Professor Hiroyuki
Date, Ph.D., Dean, Faculty of Health Science,
Hokkaido University and Associate Professor
Sophon Napathorn, M.D. Dean, Faculty of
Medicine, Chulalongkorn University signed in theAgreement at Faculty of Medicine, Chulalongkorn
University in Bangkok, Thailand. During this period
the Faculty FHS had an opportunity to visit theRose Garden at Sampran where the Thai culture
was collected in this village of Thai house, Thaifood and the use of the elephant for dragging
the log from high hill down to the ground. The
elephant riding is arranged for those who love
elephant.
My first official visit to Faculty of Health
Sciences, Hokkaido University was on
July 3, 2015 on the Second International
Conference of FHS Hokkaido University withmy presentation on Academic Activity andClinical Research at Department of Radiology,
Chulalongkorn University. Poster on “Activity
at King Chulalongkorn Memorial Hospital andChulalongkorn University” had been displayed. It
is an impressive conference as the FHS students
spoke English and little Thai — nice for theexchange program. I have been taken to the oldJapanese house learning about the culture which
partially similar to Thai culture. My second visit
was held on July 6, 2017 on Hokkaido Summer
Institute. At the 3rd International Conference of
FHS Hokkaido University, the paper title “Image
Quality and Dose Efficiency Evaluation of Added

Beam-Shaping Filter in Computed Tomography
for Pulmonary Nodule Detection: Phantom Study”
had been poster presented. One lecture had beenpresented title “The Current Status of Eye Lens
Dose Measurement on Interventional Cardiology
Personnel in Thailand”.
In July 2015, Dr. Noriyuki Tawara from FHS
Hokkaido University had spent 3 months at
Department of Radiology to teach the graduate
students on the physics of MRI and conduct
research on muscle MRI.
In December 17–23, 2015 and August 17–23,
2016, Professor Masayori Ishikawa visited Thailand
on exchange program and gave lecture on
Teacher’s Day and attended the new year party.
It is really the great opportunity for both
universities on the exchange of university staff
and the graduated students. We are grateful to
FHS Hokkaido University and wish to continue thisactivity forever.

Poster Presentation at the FHS in 2015

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student and applied to my research as well.
From the statement of “Through travel, ourfeet learn how to form their own paths and ourheart begins to beat to a different rhythm”. I truly
thanks to the chance that I participated at the FHS
symposium. I had once again the opportunity tospend away from familiar routines, allowing me
to open-up my new world and embrace myself.
I observed the graceful Japanese culture andtraditional way of life of the peaceful people. I
totally agreed with that exposure to new cultures,
like graceful Japanese culture brings entire sets of
new traditions, each with their own quirks. I havelistened to Japanese music, tasted Japanese foodsand enjoyed Japanese architecture. Furthermore,
I have surrounded with delightful Japanesepeoples. They were very kind and gentle with me,
especially they made me feel like I was at home at
all time I was living there.
For my daily routine, I loved to walk around
Hokkaido University’s Campus. There were various
places in the campus that I really like, included theCentral Lawn, Statue of Dr. William S. Clark, Elm
Forest, the Hokkaido University Museum, and Ono
Pond. For my free time, I enjoyed walk through avery calm and relaxed space of Odori park. Afterenjoying the city day tour, Sapporo’s night view
was so extremely beautiful that it was included
Sapporo TV tower. As Sapporo in particular is the“City of Food”, where fresh ingredients are broughtin from all across Hokkaido. Even by now, I am still
having the image of delicious seafood, Hokkaido
melon, ramen noodles, and special soup curry.
Additionally, variety of specialty dishes making
Sapporo the foodie heaven in my memory.
All in all, the opportunity to attend the FHS
symposium has given me a lot. The time I wasa wonderful symposium
and hope to get a chance
to participate such an eventfrom you again soon in the future.
“The FHS symposium was a grand success!”“Congratulations on a job, WELL DONE!”N

I would like to take this opportunity to express
my heartfelt thanks to you for your very active
organization in the FHS international conferenceat the Hokkaido University. My colleagues andI applaud your work in making the symposium
a success. We knew that your organizationcommittees would do an outstanding job.
The lectures covered a broad spectrum of
topics, so everyone felt that there was somethingof interest for them. I do believe that all
participants came away from each session withrenewed enthusiasm for their work. Moreover, you
did a fantastic job of keeping the meeting moving,exclusively for a session of speed-talk presentation.
For other academic activities, attending theclassroom with Japanese and Taiwan students
was one of my favorite activities. It was my newexperience that I have never been done before.
We were sharing our professional knowledge
information, as well as our multi-culturalexperiences. I have learned that there is slightly
different in healthcare management and clinicalpractice among these countries. So, I can furthertransfer some of that interesting knowledge to myThai radiological technology students. In addition,
I also have a chance to visit and meet thehealthcare professional team of the Departmentof Radiology, Hokkaido University Hospital. The
working atmosphere in the sector of diagnostic
radiology, radiation therapy, nuclear medicine
and proton therapy were superb. Moreover, I had
the opportunity to exchange many of interestingknowledge with excellence professors from Japanand othercountries. Thiscan be further
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Dr. Thititip Tippayamontri

spend in Hokkaido, it was one of the wonderful
moments of my life. I have collected the goodexperiences and memories, including excellence
academic and non-academic experiences, andgood friendship for further endless collaboration.
I once again would like to thank you for such

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The 4th FHS International Conferenceat the Hokkaido University

Somewhere in Time— Reflections on the Past FHS International Conferences —Dr. Shih-fen Hsiao
College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

I am also honored to have the chance to talkabout my memory of the FHS International
Conferences, and acknowledge my gratitude
and appreciation to those who have made theconferences come true.
My first encounter with the FHS International
Conference was in 2013, when I was a visiting
scholar to Professor Asaka’s motion lab. I
remember it was also the first FHS International
Conference (the theme was ‘Evolving Health
Sciences in Asia’) and took place on the first weekof July. I was due back to Taiwan at the end of that
July so it was just like a closure of my one-year

visit to Hokkaido University. I was particularly
amused to find myself as a ‘local’ participant –comparing to other guests from Taiwan (they werefrom Taipei Medical University). And it was then I
realized I have already made Sapporo ‘home’ andhad created quite a remarkable relationship withthe physical therapy faculties and students whom I
learned not only skills of laboratory work but also
attitude of research.
After I left Sapporo and returned to Taiwan, theinteraction between me and the FHS (especiallythe division of physical therapy/rehabilitation
sciences) actually got stronger with time went on.

15and endless supply of Sapporo Beer. For us fromthe Asaka Lab, we ended the night always with agroup photo of Professor Asaka and all research
students including our visiting youngsters from
KMU. For me it was a symbol of generation andpedigree, and a reassurance of friendship. To all our
visiting students the FHS International Conference
was the first international scientific conference of
their life time, and some of them have already theirmaster degree or are still doing research. Thanks
to the platform and links created in the series of
FHS International Conference! This is well beyond
my imagination and expectation when I started myvisit to Hokkaido University in 2012!
Given the globalized and interconnected
health science network created by the FHS
International Conferences, I think it has becomea tradition for the health science people rather
than just an event on the academic calendar.
Thanks to the leadership and vision of Dean Date,
Dean Saito and Professor Yamauchi, and thanks
to Professor Asaka and Professor Samukawa
for implementing the PT exchange program, I
am extremely honored to be part of the storyof these conferences. I believe each of us fromvarious countries were just like a single thread,these conferences have pulled us all together andwoven into a strong and beautiful fabric to cover
the healthcare and health science needs.
I sincerely wish the collection of this book leadto a new extension of next conference, and I lookforward to meeting old friends and the ambitious,
next generation of the health sciences field.

From

If there was a loyalty card for collecting points,
I should have got 5 points for attending each of
the conference including the virtual conference
last year! In 2014 a memorandum of academic
collaboration and student exchange agreement
were signed between FHS and the College of Health
Sciences of my university, Kaohsiung Medical
University (KMU), and it became a custom for us tosend PT students for one-month summer exchange
during the year whenever the FHS International
Conference took place. It was a great experience forour students to attend the international conference
as undergraduates, but for me, attending the FHS
International Conference was a perfect excuse to
get away from busy teaching and administration
works, and I always felt so excited to meet friends
and lab members from the old days, and the
Sapporo soup curry (Picante has always been myfavorite)! I remember clearly the excitement of
the shotgun presentations — well, to recite yourprecious research works concisely in one minute isnever an easy job! Not only the amounts of posters
but also the variety and quality also increased
year by year, and it was such a pleasure to talkto those young and ambitious minds. I was alsofascinated by the wide spectrum of topics deliveredby international speakers encompassing significant
health science issues from obesity of children toenvironmental health.
But I believe the climax of the FHS International
Conferences was the dinner party on the last day
as the friendship among all participants knitted
stronger with toasting to success of the conference

H
O
N
G

KO
N
G

The first bento after
arriving at Hokkaido
University

Discovering Hokkaido— Intellectuality and Humanity Besides —Professor Chia-Chin Lin
School of Nursing, The University of Hong Kong, Hong Kong, China

Hokkaido is an amazing place which is famous
for its picturesque scenery surrounded by plenty ofmagnificent natural landscapes. It has been one of
the top destinations for my vacations where I had
many precious memories and enjoyable momentswith my family members. In July 2015, I had been
invited by Hokkaido University to attend the FHS
International Conference and had the opportunity
to visit this wonderful place again. I had a pleasant
stay there thanks to the perfect weather as well as
the great hospitality from the host university andlocal people.
During my visit, I had great pleasure to meetwith the Dean Professor Date, as well as mystudents from TMU who were visiting Hokkaido
University for an exchange programme. It was
exciting to meet with my students who had shared
bits and pieces of their life as exchange students
and to learn that all of them had enjoyed theirexchange experiences there.
Besides, I was really impressed by the beautifulGroup photo of Asaka lab
and also Professors Maejima
and Samukawa during the
3rd FHS in 2017

Dean Huang of Collegeof Health Sciences KMU
and the visiting students(left) , KMU students
with Professor Asaka(right) , in the 4th FHS
in 2019

16

Morning run in thebeautiful campus

campus of Hokkaido University and the tranquilityof its natural and spacious environment. I had theprivilege of feeling the breeze, smelling the trees,and hearing the sounds of nature while jogging
around the campus every morning. And I had
bumped into one of my colleagues who is a runnerwhen I was jogging.
During the spare time of my visit, I had exploredsome of the must-see attractions and delicious
local cuisine in Sapporo City. I had also spent somedelightful moments reminiscing and reconnectingwith my old friends while enjoying the dinner ina local restaurant. I had enjoyed the local cuisine
and Sapporo ramen is one of my favourites. I also
love the fresh fruits from the local farms especiallythe juicy peaches which are in season during
summer time.
It has been seven years since my last visit to
Hokkaido, yet all these good memories are still
lingering in my mind. And I really hope I can travelto this beautiful place again in the near future.

Dinner with myold friends

Meeting with Dean
Professor Date andmy students visiting
Hokkaido University foran exchange programme17Poster session of the 4th FHS in 2019

The reception desk of the 1st FHS in 2013
(Photo by Dr. Hsiao)

Programs&

Students in the 3rd FHS in 2017 (Photo by
Dr. Hsiao)

Symposium session of the 3rd FHS in 201718

Welcome reception of the 1st FHS in 2013

Abstracts& Best Poster Presentation Awardees 2015–2021

- Evolving Health Sciences in Asia July 5, 2013
School of Medicine, Hokkaido University
Clinical Medicine Lecture Building

Program Schedule
8:30–9:00

Registration

Prof. H. Date
(Dean, Faculty of Health Sciences, Hokkaido University)
Prof. M. Kasahara
Welcome Address(Dean, School of Medicine, Hokkaido University)
1. Taipei Medical University / Prof. C-C. Lin
Introduction:
Universities / Institutions 2. Diponegoro University & Dr. Kariadi Hospital / Dr. M. Mexitalia
Chair: Prof. T. Yamauchi 3. Hokkaido University / Prof. T. Yamauchi
Break
1. Dr. M. Mexitalia (Diponegoro University / Dr. Kariadi Hospital)
Non alcoholic fatty liver disease (NAFLD) and metabolic syndromeof Indonesian obese adolescents in Semarang
Session 1:‘Medial Science’
2. Dr. J. Ohashi (University of Tsukuba)
Molecular evolution of TRAP gene in P. falciparum
Chair:
Prof. H. Yamaguchi
3. Dr. J. Matsuo (Hokkaido University)
Learning from bacteria-protist interactions: from human-healththreat to infection control
Lunch
4. Prof. C-C. Lin (Taipei Medical University)
Evidence-based practice in Taiwan: Wan Fang Hospital as an
Session 2:
example‘Nursing’
5. Dr. M. Sato (Hokkaido University)
Chair:
Self-care in adults with diabetes
Dr. Y. Asaka
6. Dr. M. Noguchi (Hokkaido University)
Midwifery to improve maternal and child health for global health
Break
7. Prof. H-Y. Chiou (Taipei Medical University)
Health system reform on NCD in Taiwan
Session 3:‘Rehabilitation and Public
8. Dr. R. Handoyo (Diponegoro University / Dr. Kariadi Hospital)
Health’Application of rehabilitation principles in musculoskeletal
degenerative diseases
Chair:
Prof. H. Tohyama
9. Dr. M. Samukawa (Hokkaido University)
Stretching to achieve optimal athletic performance
Prof. T. Saito
Closing Remarks(Vice-Dean, Faculty of Health Sciences, Hokkaido University)
Opening Remarks

9:00–10:30

10:30–10:50

10:50–12:05

12:05–13:30

13:30–14:45

14:45–15:00

15:00–16:15

16:15–16:30

20

Non alcoholic fatty liver disease (NAFLD) and metabolic syndrome ofIndonesian obese adolescents in Semarang
Maria Mexitalia

Pediatric Department, Faculty of Medicine Diponegoro University /Dr. Kariadi Hospital, Semarang, Indonesia

The key components of metabolic syndrome are central obesity, atherogenic dyslipidemia, impaired glucose
tolerance, and elevated blood pressure. In children, non alcoholic fatty liver disease (NAFLD) has been
consistently associated with metabolic syndrome. We compiled 5 studies of metabolic syndrome of theadolescents in Semarang during 2007–2012. A study of 116 adolescents found that the prevalence of metabolic
syndrome among the obesity was 31,6% meanwhile none of the normal students got the metabolic syndrome.
Other study with smaller number of subjects found that hypoadiponectin was not associated with NAFLD inobese adolescents. Discriminant analysis between adiponectin level and HOMA > -0,259 may predict NAFLD
in obese adolescent. A study by assessing the correlation between aspartat amino transferase-platelet ratio index(APRI) as early identification of fibrosis and body mass index in fatty liver children found that there was nocorrelation between APRI and (BMI), and only 5% obese children with fatty liver indicated liver fibrosis.
Meanwhile the other study of us found a positive correlation between waist, body fat, lipid profile, alaninetransaminase, and insulin resistance with hsCRP as early marker for atherosclerosis. The risk of children withmetabolic syndrome affected NAFLD was 5.6 times greater than non metabolic syndrome. The last study was
the intervention study of diet modification given to NAFLD adolescents found that there was no significant
differences on fibrosis cirrhosis index (FCI) score before and after diet modification by groups.
As summary, we concluded that NAFLD in obese adolescents was associated with metabolic syndrome.
For adolescents with NAFLD, a goal must be the prevention of end-stage liver disease. In addition, children
with NAFLD may be at a higher risk for cardiovascular disease than children without NAFLD. Although ourintervention with diet modification could not revealed the differences of fibrosis cirrhosis index (FCI) score, butthere was a good improvement on liver function.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The 1st FHS International Conference

Molecular Evolution of TRAP gene in P. falciparum
Jun Ohashi

Molecular and Genetic Epidemiology, Faculty of Medicine,
University of Tsukuba, Tsukuba, Japan

Malaria infection starts when the sporozoite stage of the Plasmodium parasite is injected into the bloodstream by
an infected female Anopheles mosquito. The sporozoites pass quickly into the liver, where they infect hepatocytes.
Thrombospondin-related adhesive protein (TRAP) is a protein expressed in sporozoites and essential for
sporozoite gliding and cell invasion. To study the molecular evolution of TRAP gene in Plasmodium falciparum,
the TRAP polymorphisms were investigated in 32 P. falciparum isolates obtained from Suan Phueng District inRatchaburi Province, Thailand. The analysis of the entire TRAP gene sequences in 32 isolates identified a totalof 39 single nucleotide polymorphisms (SNPs) in the coding region of the TRAP gene: 37 nonsynonymous
SNPs and two synonymous SNPs. A comparison of our P. falciparum isolates with those in the other regionof Thailand and Gambia indicated that TRAP is highly differentiated even between the geographically close
regions. An evolutionary analysis suggested that diversifying selection is acting on the TRAP gene in Thai P.
falciparum population. The possibility that TRAP can be a major target of human malaria vaccine development
will be discussed further in this presentation.

21

As viewed from the point of environmental ecology widely spreading soil, river water or gut, microbialcommunity comprising both protists (e.g. amoebae and ciliates) and prokaryotes (harmless bacteria) plays amajor role in nutrient cycle. Meanwhile, since protists can be significant predators of bacteria, some bacteria
have evolved variety of mechanisms to survive within protists, including escape from phagocytosis, acquisitionof virulent factors and horizontal gene transfer. Such bacterial strategies against protists are also commonly seen
into pathogenic bacteria to successfully adapt to mammalian cells (e.g. macrophages), and it seems reasonable
to suggest that studies on interactions between bacteria and protists may give us a new insight to understandbacterial pathogenesis into developing appropriate infection control system. Hence, we have begun to study
how symbiosis occurred by using amoebae (Acanthamoeba) with endosymbiotic bacteria that we originallyisolated from Sapporo City. In this session, we would like to show several intriguing findings that some amoebal
endosymbiotic bacteria manipulate growth speed and motility of host amoebae. We will also introduce our data
indicating that ciliates (Tetrahymena) significantly enhance the frequency of bacterial gene transfer, possibly
responsible for multidrug resistant bacteria.

3 approaches to fostering the development of translational research in cancer nursing. First, to be successful,the translational research paradigm should be started from educational programs. Students should be offeredan opportunity to work with an interdisciplinary mentoring team, and to be exposed to bench science as wellas to patient-based and population-based research (Feldman, 2008). Communications and collaborations
across disciplines are central to cancer care and to translational research. Such a benefit of a translational
research program gives the opportunity to use it as a platform for developing closer relationships with othercare disciplines. Second, nursing researchers are encouraged to explore the “why” and “how” regarding ourinterventions, including psychological as well as biological mechanisms. For this purpose, an interdisciplinary
research team and a transfer of understandings of psychological or biological mechanisms into the developmentof interventions will need to be formed. Nursing research has a rich tradition of attempting to measure andunderstand relationships among the variables in question. As we engage in translational research, more emphasis
must be placed on how relationship variables explain differential interventional effects (Woods and Magyary,2010). Lastly, the research findings may take several decades to be translated into standard health care practiceor guidelines; therefore, more effort of cancer nursing research must be directed at distilling the knowledge
gained from practice-based research through systematic reviews and guidelines that can be implemented inpractice and assist in clinical decision making.
In conclusion, translational research holds great promise for improving care for cancer patients worldwide.
The concept of interdisciplinary collaboration between basic researchers and clinical researchers, and efforts
at the translation of new knowledge into clinical practice will certainly advance the quality of cancer care.
Nursing researchers such as yourself are encouraged to take the initiative to contribute to translational researchin patient care.

Evidence-Based Practice in Taiwan: Wan Fang Hospital as an Example

Self-care in Adults with Diabetes

Chia-Chin Lin

Miho Sato

Junji Matsuo

Department of Medical Laboratory Science, Faculty of Health Sciences,
Hokkaido University, Sapporo, Japan

22

College of Nursing, Taipei Medical University,
Taipei, Taiwan

Department of Fundermental Nursing, Faculty of Health Sciences,
Hokkaido University, Sapporo, Japan

Research has been grouped into 2 categories: basic and clinical research. Basic research focuses on knowledge
in cancer biology, whereas clinical research has traditionally focused on the investigation of new treatment
modalities. In recent years, it has become evident that the interaction between basic and clinical researchers
can improve the outcomes of cancer patients. Translational research has become a new concept for bridging
between basic research and clinical research, and even health decision making. The term translational research
usually refers to “from bench to bedside,” and the endpoint of this area of research is the production of apromising new treatment or intervention that can be used clinically or commercially (Woolf, 2008). However, forresearchers whose studies focus on health care, translational research refers to translating research into practice.
Therefore, the Institute of Medicine’s Clinical Research Roundtable has provided a distinction between these 2
definitions of translational research (Sung et al, 2003). T1 is defined as “the transfer of new understandings ofdisease mechanisms gained in the laboratory into the development of new methods for diagnosis, therapy, andprevention and their first testing in humans.” T2 is described as “the translations of results from clinical studies
into everyday clinical practice and health decision making.”
Efforts at translational research from nursing professionals have been relatively limited in the past. However,nursing is in a unique position for contributing to interdisciplinary translational research because nursing practiceis distinguished from most other disciplines by the fusion of the biological, psychological, and sociocultural
perspectives regarding the care of people (Woods and Magyary, 2010). Moreover, nursing care and research
are highly linked with the community and ambulatory care settings, where population-based interventions andpracticebased research networks serve as the “laboratory” for T2 research (Woolf, 2008). Therefore, I propose

The number of people with diabetes in Japan has increased steadily. Serious complications resulting fromdiabetes could have negative impact on the quality of life. In order to prevent these problems and manage
diabetes effectively, people with diabetes are expected to adhere to daily self-care. It includes following a mealplan, engaging in appropriate physical activity, medication adherence if needed and monitoring such as blood
glucose testing. However, not all patients follow the recommended activities. Why wouldn’t they maintain selfcare? What makes people engage in self-care?
Self-care behaviors can be influenced by a range of broad factors. It is well explained by a framework called“the ecological model of health behavior”. In this presentation, factors influencing self-care for people withdiabetes will be discussed from two viewpoints. The first is factors at individual levels, such as knowledge, selfefficacy and emotional aspect. The second is social and contextual factors surrounding the individuals, such associal support and neighborhood resources. The work-related factors will be also discussed. The previous study
indicated that factors such as working night shifts, self-disclosure of diabetes and workplace conformity had asignificant influence on dietary self-care.
In order to help people with diabetes behave in healthy ways, recognizing multiple factors is important.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Learning from bacteria-protist interactions:from human-health threat to infection control

23

Makiko Noguchi

Department of Comprehensive Development Nursing,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Midwifery is essential to improving maternal and child health. A midwifery approach should be established andfostered all over the world, because improvements in maternal and child health have not progressed sufficiently
toward achieving the Millennium Development Goals adopted by heads of states in September 2000.
According to the United Nations Population Fund (2007), it is clear that strengthening skilled midwifery
workforce is crucial to improve maternal and child health. But new practical ways of working and supporting
midwifery have not been established while medicalization of birth which includes ineffective and harmful
practices for mothers and babies has become more rapid and widespread.
Japanese project teams utilizing midwifery have been conducting projects overseas to cope with the
medicalization of birth and its negative effects, because Japanese midwives can support natural or physiologicalbirth. Many midwifery training programs were conducted by Japanese midwives and were a success. A
reproductive health project in Armenia was one of the projects to provide midwifery care. It is not easy toclearly define global standards of midwifery approach, because maternal health depends on social and cultural
aspects indigenous to the society. An impact of midwifery care is also not recognized sufficiently compared toconventional medical care. We should, therefore, provide actual results of the midwifery projects to disseminate
midwifery practicality.
It is an urgent task that valid, reliable and accessible indicators to evaluate midwifery care be clarified toadvance midwifery.

Application of Rehabilitation Principles
in Musculoskeletal Degenerative Diseases
Rudy Handoyo

Physical Medicine and Rehabilitation Department, Diponegoro University /Dr. Kariadi Hospital, Semarang, Indonesia

As a shift in demographics occurs with the increase of life expectancy and a growing elderly population, theprobability of encountering patients with musculoskeletal degenerative disease increases. The commonly
problems of the disease are pain, stiffness and decreased range of motion. These findings combine to decrease
overall activity, which in turn leads to physical deconditioning and therefore interferes with the patient’s ability
to perform basic of activity of daily living. The primary goals of rehabilitation of musculoskeletal degenerative
disease such as to decrease symptoms, to optimize daily function and to minimize disability. The efficacy ofvarious modalities for the treatment of musculoskeletal degenerative diseases were presented. Furthermore, anunderstanding of the role of biomechanics in the manifestation of the musculoskeletal degenerative diseases isessential in the assessment and management of the patient. The rehabilitation may implement strengtheningof the muscle around the joint to correct for biomechanical deficits and utilize orthoses or assistive device toprotect and decrease load on the joints. The emphasis of the treatment of rehabilitation should include active
participation of the patients.

Stretching to achieve optimal athletic performance
Mina Samukawa

Health System Reform on NCD in Taiwan
Hung Yi Chiou

College of Public Health and Nutrition, Taipei Medical University /Taiwan Public Health Association, Taipei, Taiwan

According to a 2011 World Health Organization report, 63% of global deaths were due to NCDs (mainly
cancers, diabetes cardiovascular diseases and chronic respiratory disease). In Taiwan, NCDs accounts for nearly
60% of deaths. The four leading risk factors changing lifestyle are smoking, inadequate exercise, unhealthy dietand harmful use of alcohol. Aging population and increasing prevalence of non-communicable disease (NCDs)
have become major health threats. These challenges such as aging population and increase in NCDs requirepreventive measures and health promotion from leading public agencies.
In order to reduce the impact of NCDs on health expenditure, Taiwan government launched numerous
programs recent years, include Health Centenary, Health Taiwan. This nationwide campaign encouraged people
to maintain a healthy body weights. Another important part of health promotion efforts was tobacco hazard
prevention an d control.
In 2011, the exposure rate to secondhand smoke in public places was under 10% (8.2%), and 90% of people
were satisfied with the progress. Moreover, Taiwan has set a target of reducing the cancer mortality rate by 20%
by 2020. To reach this goal, free screening are offered for the four major cancer types (cervical cancer, breast
cancer, colorectal cancer and oral cancer). In 2011, 4.35 million of these screening were conducted.
With limit resources, we still hope our work is evidence-based and our love for life serves as the motivating
force. By mobilizing society and its constituents through bring policies in line with international practices.

24

Department of Rehabilitation Sciences, Faculty of Health Sciences,
Hokkaido University, Sapporo, Japan

Athletes commonly include stretching exercises in their warm-up routines. In winter sports, athletes arecommonly required to perform in cold environments; so effective stretching is considered essential. The mostcommon method is static stretching, which places muscles in their lengthened positions and maintains these
positions for a certain period of time. However, static stretching has also been found to have negative effects
on athletic performance. By contrast, dynamic stretching consists of performing movements that take the limb
through a range of motion by contracting the agonist muscles, which in turn allows the antagonist muscles
to relax and elongate. Dynamic stretching is now gaining recognition as an effective exercise for improving
sports performance. The results of our recent studies suggested that the effects of dynamic stretching on themuscle-tendon unit were quite different from those of static stretching. The precise mechanisms why dynamic
stretching optimizes performance needs to be better understood so that stretching programs can be tailor-madefor individual athletes.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Midwifery to improve maternal and child health for global health25

Early Life Nutrition, from Breastfeeding to Complementary Feeding

July 3, 2015

Maria Mexitalia- Gazing into the Future of Health Sciences in Asia Faculty of Health Sciences, Hokkaido University
Multipurpose room, E building 1F

Program Schedule
8:30–9:00
9:00–9:10

9:10–10:45

Registration

Opening Remarks

Symposium
Session 1
Chair:
Prof. T. Yamauchi

10:45–11:15

11:15–12:25

Symposium
Session 2
Chair:
Prof. K. Denda

12:25–13:30

13:30–14:40

Symposium
Session 3
Chair:
Prof. M. Ishikawa

14:40–15:00
15:00–17:00
17:00–17:05

26

Prof. H. Date
(Dean, Faculty of Health Sciences, Hokkaido University)
1. Maria Mexitalia (Diponegoro University / Dr. Kariadi Hospital)
Early life nutrition, from breastfeeding to complementary feeding
2. Agustini Utari (Diponegoro University)
Endocrine Disrupting Chemicals (EDCs) : a risk factor for thyroid
disorders
3. Chia-Chin Lin (Taipei Medical University)
Does physical activity have a value in palliative cancer care?
4. Shu-Huei Kao (Taipei Medical University)
OPA1, the causal protein for autosomal dominant optic atrophy, involves
in mitochondrial bioenergetics and genome stability
Tea Break
5. Shih-Fen Hsiao (Kaohsiung Medical University)
Assessing clinical skills with OSCE: pearls and pitfalls
6. Yu-Sheng Yang (Kaohsiung Medical University)
Touch screen rehabilitation system for paretic upper limb after stroke
7. Tatsuo Hatta (Hokkaido University)
Development of a new wheelchair component to improve seated postureof elderly individuals
Lunch
8. Anchali Krisanachinda, Sivalee Suriyapee (Chulalongkorn
University)
Education and research in medical imaging at Chulalongkorn
University
9. Sukalaya Lerdlum (Chulalongkorn University)
Academic activity and clinical research at Department of Radiology,
Chulalongkorn University
10. Tamotsu Kamishima (Hokkaido University)
Semi-automatic computer-based roentgenographic quantification of
joint space width difference using temporal subtraction: initial study
with phantom and finger joint in patients with rheumatoid arthritis
Tea Break
Poster Session

Closing Remarks

Prof. T. Yamauchi(Chair, Committee on International Affairs, Hokkaido University)

Department of Pediatrics, Faculty of Medicine, Diponegoro University /Dr. Kariadi Hospital, Semarang, Indonesia

Early life nutrition plays an important part of children lives, supporting the ongoing development of theirbrain and immune systems, as well as impacting the growth and health into adulthood. Malnutrition sufferedduring the first 2 years of life may causes stunting and have impaired intellectual performance and reduced
capacity for physical work. To prevent malnutrition, every children need to get exclusive breastfeeding and starts
complementary feeding from the age of 6 months to fill the energy and nutrient gap. The types and adequate
food density and the appropriate time for introducing complementary foods, are crucial factors to be consideredof infant and child feeding practices. Approximately 50–60% parents reported that their children suffer fromfeeding problems. Upon further evaluation, around 20–30% of those children suffer from true feeding problems
and 1–2% of them suffer from serious and persistent feeding problems. We reported some researches of earlylife nutrition. It starts from breastfeeding practices in neonates period, with the purpose was to help the parents
and health providers understood the breastfeeding mechanism in relation with growth on the first week oflife. We also reported that inappropriate complementary “feeding rules” had contributed to underweight andstunted among 6 to 24 months children in rural area of Central Java and Papua. Meanwhile the last chapter ofour researches discussed about the effect of intervention by counceling of “feeding rules” to nutritional statusof children ages 6–24 months in three provinces of Indonesia i.e Semarang (Central Java), Flores (East Nusa
Tenggara) and Sentani (Papua).

Endocrine Disrupting Chemicals (EDCs):
A Risk Factor for Thyroid Disorders
Agustini Utari

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The 2nd FHS International Conference

Department of Pediatrics, Faculty of Medicine,
Diponegoro University, Semarang, Indonesia

There is increasing awareness in the possibility health threat posed by endocrine disrupting chemicals (EDCs)
which is man-made chemicals in our environment, food, and consumer products that can disrupt the synthesis,
circulating level, and peripheral action of hormones.
Thyroid hormones is essential for normal brain development, control of metabolism and many aspectsof normal physiology. There is increasing evidence that thyroid is vulnerable to endocrine-disrupting effects.
Environmental chemicals may hamper with thyroid homeostasis through some mechanism of action such as
in binding to transport proteins at the receptor level, modifying the metabolism of thyroid or in cellular uptake
mechanism.
In some agricultural area, pesticides will use frequently for long time period. Pesticide can play a role asendocrine disrupting chemicals (EDCs) which may interfering with the activity of thyroid hormones. In ourstudies, we found that there is increasing thyroid stimulating hormones (TSH) level in children with chronic
exposure of pesticide. There is also increasing risk of goiter and subclinical hypothyroidism among children in
the area of chronic exposure of pesticide. These result should increase our awareness about the link between
EDC and thyroid disorders.

27Assessing Clinical Skills with OSCE: Pearls and Pitfalls

Chia-Chin Lin

Shih-fen Hsiao

School of Nursing, College of Nursing,Taipei Medical University, Taipei, Taiwan

Department of Physical Therapy, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

In a series of studies by our research group on physical activity intervention in lung cancer patients, we
determined that 85.2% of the participants preferred to receive physical-activity counseling during their cancer
experience. Walking was themost preferred form of exercise. Exercise adherence is a challenge for lung cancer
patients. Participants with higher social support and self-efficacy are more likely to initiate physical activity andparticipate in a moderate- to vigorous-intensity physical activity program. Social support and self-efficacy are
the main factors required for maintaining walking exercise for 6 months. Moreover, in a randomized control
trial, lung cancer patients in an exercise group exhibited significantly greater improvements in their anxiety
and depression levels in the third and sixth months than did patients in the usual-care group. Overall then, thebenefit of exercise and physical activity for patients in curative cancer treatment is fairly well established. The
benefit during end of life is not yet established.
In conclusion, there is insufficient evidence to evaluate the effectiveness of physical activity in cancer patients
receiving end of life care; however, a potential role for physical activity as a supportive care intervention seems
promising. Nevertheless, physical activity preference, social support, and self-efficacy must be considered when
implementing a physical-activity program for cancer patients receiving end of life care.

Healthcare education today reflects on the quality of tomorrow’s healthcare services. Therefore measurements ofclinical skills before or after clinical placement need to be justified to reflect competency in clinical performance.
The use of objective structured clinical examinations (OSCEs) and standardized patients (SP), and at the sametime, attempting to simulate a realistic patient-care scenario during skill assessment is useful in physical therapy
education. The components of clinical competence such as history taking, physical therapy assessment andprocedures, interpretation of assessment results, communication, attitude etc. can be tested using agreed checklists or rating scales. However, an OSCE is not without the pitfalls just like other assessment - more expensive
in terms of human resources and space, and the time required to prepare and set up such examinations is greater
too. This talk will describe the experiences in developing OSCEs specific to neurologic physical therapy, before
and after clinical placement, in the Department of Physical Therapy, Kaohsiung Medical University, Taiwan,
which is the first to apply OSCEs in PT curriculum in the country. Students feedback questionnaire withfive point Likert Scale (from 1 as strongly disagree to 5 as strongly agree) was used to analyze the responses
from the student participants. Focus group discussion was also conducted with randomly selected students
and their responses were recorded. The possibility of using pre-clinical OSCEs as an indicator of clinicalperformance during placement, validity of post-clinical OSCEs, perceptions of students about the effectivenessof implementing such clinical skill assessment, will also be discussed.

OPA1, the Causal Protein for Autosomal Dominant Optic Atrophy,
Involves in Mitochondrial Bioenergetics and Genome Stability
Shu-Huei Kao

School of Medical Laboratory Science and Biotechnology,
Taipei Medical University, Taipei, Taiwan

OPA1 (Optic atrophy 1) is the causative gene of autosomal dominant optic atrophy (ADOA) and is the central
regulators of mitochondrial network dynamics and apoptosis. We established lymphoblastoid cell lines from four
ADOA families harboring different OPA1 mutations, unaffected relatives (as internal control), and unrelated
normal controls (as normal control). Gene mutations included OPA1 whole exon 10 deletion, whole exon 12
deletion, 3 nucleotides deletion in exon 19, and a point mutation in exon 28. OPA1- mutated cell lines showedsignificant decreases in OPA1 mRNA and protein expression, mitochondrial membrane potential, and ATP
synthesis. Confocal microscopy revealed increased mitochondrial fragmentation in OPA1-mutated cells. OPA1mutated cells also displayed reduced oxygen consumption and underwent glycolysis to produce ATP. Moreover,
OPA1 mutations caused the accumulation of oxidative damage. In addition, we found that OPA1 mutations
induced formation of mitochondrial DNA (mtDNA) deletions and 8-hydroxy-deoxyguanosine, decreased
mtDNA copy numbers, and affected mitochondrial nucleoid distribution. Our experiments demonstrated
that OPA1 mutations induced mitochondrial fragmentation, uncoupled mitochondrial respiration and elicited
dysfunctional bioenergetics. OPA1 mutation leads to mitochondrial nucleoid disruption which may cause
mitochondrial genome instability and respiratory chain dysfunction.

28

Touch Screen Rehabilitation System for Paretic Upper Limb after Stroke
Yu-Sheng Yang

Department of Occupational Therapy, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Does Physical Activity Have a Value in Palliative Cancer Care?

One of the most debilitating deficits after stroke is upper-extremity (UE) paresis. Surprisingly, interventions
to address UE paresis are often inconsistently applied in routine clinical settings and even neglected at various
stages of stroke recovery. When provided, UE interventions often consist of various therapeutic approaches
provided in low doses, as observed during delivery of clinical services. Task-specific UE trainings with highrepetition have been shown to have beneficial effects for some people with stroke. This type of individually
tailored, progressive UE training can also be done in an outpatient setting for extended hours. We developed aprototype touch screen rehabilitation system for UE motor rehabilitation. In this system, we introduce touch
panel games into the UE training, motivating the user to actively participate in the rehabilitation and making
the whole process reliable and retrievable. The patient or therapist can obtain performance scale from a databasemanagement system to monitor improvement. This system includes five high repetition programs for UE
training and three operation models. Our pilot study showed that the score of UE training programs had highcorrelation with Action Research Arm Test, Grip strength, and Box and Blocks test. It indicated that this touch
screen rehabilitation system is suitable for UE training in patients after stroke.

29

Academic Activity and Clinical Research at Department of Radiology,
Chulalongkorn University

Tatsuo Hatta

Sukalaya Lerdlum

Department of Functioning and Disability,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Department of Radiology, Faculty of Medicine,
Chulalongkorn University, Bangkok, Thailand

Wheelchair users frequently sit in standard straight-backed wheelchairs with a hunched forward head posture(FHP). FHP is one of the most common posture disorders and is assumed to be associated with thoracic
kyphosis. To prevent FHP, we developed a new wheelchair component. The component called an “ABS pelvic
support” comprises two metal attachments, one pelvic and one thoracic belt. Setting the component for clinicalapplication is based on the condition of the pelvis and the curvature of the spine. We then investigated theeffects of the component on the seated posture of elderly individuals. Eighteen healthy elderly individuals
sat on wheelchairs with the component (WCO) and without (NCO). We analyzed seated postures using theDartfish movement analysis system and the pressure distribution on the buttocks and back using the Force
Sensitive Application. The posterior inclination of the trunk, head and neck was significantly increased on WCO
compared with NCO. The maximal and average values and the sensing area of the buttocks were significantly
lower, whereas the average value and the sensing area of the back were significantly higher on WCO rather
than NCO. The increased head and neck posterior inclination on WCO indicated that the component might
prevent FHP. The increased trunk inclination and pressure distribution on the back also indicated that thebelts supported the trunk along the physiological curve of the spine, which might provide a stable base forappropriate head and neck alignment.

The education includes the undergraduate and post graduate programs. The clinical training is organized forresidents, Fellow in radiology, and medical physicists which research involves in all programs. Various resources
are available in the department from human, equipment, patients, research support team and research fund.
Inter-departmental research such as HIV studies, epilepsy and Alzheimer’s disease investigated by SPECT and
MRI, are increasing in the last 10 years. International Atomic Energy Agency offers inter-regional research
title ‘Evaluation and Optimization of Pediatric Imaging’, ‘Development of Quantitative PET/CT Imaging for
Optimized Patient Specific Dosimetry’. Department research is about 30 topics per academic year. Researchin nuclear medicine involves both imaging and treatment. For treatment, the majority are in treatment ofhyperthyroid and thyroid cancer, which is descriptive and experimental as well as studying molecular and genetic
aspects in collaboration with other departments. For imaging, we currently undergo brain, kidney, bone, thyroid,
heart researches. Imaging studies and bone mineral density measurement in HIV patients are continued inmany aspects. Technologists and nurses are also doing their research in nuclear medicine techniques to develop
the routine studies for the safety of the patients. Researches in radiation oncology focus on radiation treatment
in several kinds of cancer and also physics of advanced radiation techniques. The studies are intra division study
and interdepartmental study. In addition, we have participated in an international protocol, INTERTECC trial
which is a randomized study comparing 3-Dimensional RT versus IMRT in cervical cancer patients.

Education and Research in Medical Imaging
at Chulalongkorn University
Anchali Krisanachinda, Sivalee Suriyapee
Department of Radiology, Faculty of Medicine,
Chulalongkorn University, Bangkok, Thailand

The increasing use of radiation in medicine results from the development of medical imaging technology forearly detection of cancer and leading to the curable of diseases with life longer and healthy patients. The Medical
Imaging graduate program was firstly established in the year 2002 at Chulalongkorn University, Bangkok,
Thailand. This program strengthens the scientists for their continued education with research development. The
research is mostly related to the performance study of the radiology equipment, phantom study simulate patientsto determine the skin dose and the organ dose from different modalities such as CT, fluoroscopy, mammography,
MRI, PET/CT, SPECT/CT. The followings are title of research: Determination of tumor boundary on PET
images using active contour coupled with optimal thresholding: A Phantom Study, Standardized uptake valueof 99mTc-SESTAMIBI in myocardial perfusion SPECT/CT, Influence of standard pitch and high pitch 64MDCT on lung nodule - chest protocol: Phantom study, Radiation dose and image quality from coronary
angiography in 320- detector row CT, Appropriate technique for reduce distortion in diffusion weighted
imaging MRI 1.5 Tesla, Optimal protocols of single-shot dual energy subtraction chest radiography. Medical
imaging becomes an essential part of radiotherapy as the technology has been applied and/or included inradiotherapy service with higher accuracy. The example could be counted from the use of CT simulator, MR
simulator, PET/CT and other hybrid system for treatment planning. The image guided radiotherapy for beam
verification makes use of many imaging modalities ranging from portal imaging to kV cone-beam CT.

30

Semi-Automatic Computer-Based Roentgenographic Quantification of
Joint Space Width Difference Using TemporalSubtraction: Initial Studywith Phantom and Finger Joint in Patientswith Rheumatoid Arthritis

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Development of a New Wheelchair Component to
Improve SeatedPosture of Elderly Individuals

Tamotsu Kamishima

Department of Biomedical Science and Engineering,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial membrane inflammation
leading to joint damage. Conventional radiography permits measurement of structural joint damage, which iscurrently considered the gold standard of treatment efficacy studies in RA, and scoring methods for radiography isused extensively in clinical trials as the primary outcome measure. However, currently established scoring methods,
although widely applied, have been associated with several limitations such as restricted generalizability andobjectivity due to the difficulty of standardized scoring by different readers with variable experience. To overcome
these issues, various software for use in measuring the joint space width has been reported, and this provides aquantitative, reproducible, and more objective measure to assess structural joint damage in patients with RA. To
further improve the computer-based analysis of the joint damage of RA patients, we developed and validated acomputer-based quantification of joint space width difference using temporal subtraction which can detect slightchanges in joint space narrowing ( JSN) between two images and display the joint space difference index ( JSDI).
Positive correlation was found between the difference in joint spaces and the JSDI in phantom study. JSDI of therheumatoid patients was significantly different between finger joints with and without JSN progression (p < 0.001).
The computer-based quantification of joint space width difference using temporal subtraction can recognize theinterval difference in finger joint space on radiographs and quantifies its degree objectively.

31

- Hitch our wagon to a remedy! July 7, 2017

Faculty of Health Sciences, Hokkaido University
Multipurpose room, E building 1F

Program Schedule
8:20–8:50
8:50–9:00

9:00–10:20

Registration

Opening Remarks

Symposium
Session 1
Chair:
Prof. T. Yamamoto

10:40–12:10

Lunch
5. Dr. Takayuki Furukawa (Hokkaido University)
From chemistry to the challenge for clinical chemistry
Symposium
Session 2
Chair:
Prof. S. Hui

14:10–14:30

Symposium
Session 3
Chair:
Prof. T. Yamauchi

15:30–15:50
15:50–17:20
17:20–17:30

32

3. Dr. Minghui Tang (Hokkaido University)
Evaluation of arteriolar vasomotor function by using MRINoriyo Colley

Department of Comprehensive Development Nursing,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Recently, the numbers of technology-dependent children (0–19 years old) has soared rapidly from 9,403 in 2005
to 17,078 in 2015. A training system for technical health procedures such as endotracheal suctioning and tube
feeding was enforced in 2012, and special-need-school teachers, geriatric care workers, and childcare-workers
became able to offer these procedures after training attendance. Hokkaido Government Board of Education
was registered as the type three training (targeted for a contracted student) for training teachers who newly
employed at 20 special-need schools which provide technical health procedures in Hokkaido. Simultaneously,
registered nurses have assigned to support provision of technical health procedures by teachers at school settings.
Social capital e.g. regulation, training system, and human resources, seems to be gradually fulfilled to provide
structured support for technology-dependent children and their families. However, lack of respite care facilities
made family members to decide to put their children into the long term facilities before graduation of schools.
School nurses take a full responsibility for technology-dependent children to graduate and adjust as membersof their society from nursing perspective. In the current situation after the training system has commenced,
nurses must be recognize the expectation of nursing role shift from “direct care provision” to “indirect careprovision” such as initiation of respite care services as a nursing manager in the community, orientation andconsultation of technical health procedures for families and teachers. Joint wayfinding nursing activities are
festinate tasks to create safe and comfortable learning environment for technology-dependent children andtheir families.

Poster Session 1

12:10–13:10

14:30–15:30

2. Dr. Pei-Shan Tsai (Taipei Medical University)
Mind-body interventions to improve patients-reported outcomes

4. Dr. Ming-Chung Chou (Kaohsiung Medical University)
Diffusion-weighted magnetic resonance imaging: echnical development
and clinical applications
Tea Break

10:20–10:40

13:10–14:10

Prof. T. Saito(Dean, Faculty of Health Sciences, Hokkaido University)
1. Dr. Noriyo Colley (Hokkaido University)
Professional reconstruction in nursing to support technology: dependent
children at home

Professional reconstruction in nursing to support technology:
dependent children at home

6. Dr. Horng-Mo Lee (Taipei Medical University)Nε-(carboxymethyl) lysine increased reactive oxygen species productionthat induced mitochondrial fission and mitophagy in pancreatic beta cells
7. Dr. Shih-Fen Hsiao (Kaohsiung Medical University)
Physical fitness, cognition and emotional wellbeing of older adults withand without dementia
Tea Break8. Dr. Li Cong (Hiroshima International University)
Therapeutic use of occupation in traditional Chinese medicine
9. Dr. Kyoungmin Lee (GangWon National University / Far East University)
Development of preliminary occupation-centered model in a Koreanelderly daycare center
10. Dr. Hein Mallee (Research Institute for Humanity and Nature)
From ecosystem health to planetary health: the development of “health”
as an ecological concept
Break

Mind-body Interventions to Improve Patients-reported Outcomes

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The 3rd FHS International Conference

Pei-Shan Tsai

College of Nursing, Taipei Medical University,
Taipei, Taiwan

Mind-body interventions that encompass a large group of interventions such as relaxation and breathing, taichi, qi gong, yoga, hypnosis, meditation, and biofeedback focus on the relationships among the brain, body,and behavior, and their effects on health and disease. Many of these techniques are thought to be beneficial for
conditions where psychological stress is a factor.
Relaxation breathing significantly improved pain in advanced cancer patients, depressive symptoms inpatients with coronary heart disease and patients undergoing hemodialysis. Blood pressure biofeedback andmassage both significantly reduced blood pressure in patients with prehypertension and hypertension. A wide
range of mind-body intentions has also been shown to be efficacious in improving sleep in cancer patients. This
presentation will introduce mind-body interventions, their efficacy in improving patients-reported outcomes,
and potential mechanisms underlying the beneficial effects of mind-body interventions.

Poster Session 2
Closing Remarks

Prof. T. Yamauchi(Chair, Committee on International Affairs, Hokkaido University)

33

From chemistry to the challenge for clinical chemistry

Minghui Tang

Takayuki Furukawa

Department of Biomedical Science and Engineering,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Department of Medical Laboratory Science,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Arteriolar vasomotor function which is the capability of arteriolar vasomotion, e.g. vasodilation andvasoconstriction, would be a new biomarker for early diagnosis of dementia. Invasive techniques have been
employed preclinically for assessing arteriolar vasomotor function by using vasodilator agents, such as CO2
inhalation, which are challenging for patients. On the other hand, respiration induces the spontaneous
fluctuation of CO2 concentration in arterial blood, and this CO2 fluctuation consequently causes arteriolar
vasomotion that varies cerebral blood flow and venous blood oxygenation which make MRI signal fluctuate.
Focusing on the fluctuation of time series MR signal in the superior sagittal sinus, we developed a non-invasive
method to obtain the respiratory fluctuation of venous blood oxygenation which represents the averaged
arteriolar vasomotor function in the brain. Our method was applied to young-age and middle-age healthy men
to investigate changes in averaged arteriolar vasomotor function by aging. The result that respiratory fluctuationof venous blood oxygenation in the middle-age group was significantly less than that of the young-age reflects
the degeneration of arteriolar vasomotor function with aging. We also analyzed the fluctuation in MR signal ofbrain parenchyma. An extremely strong correlation of MR signals was found between the respiratory fluctuation
at the sagittal sinus and the cardiac fluctuation in brain parenchyma; pulsatile blood pressure modulates volumeof arterioles. Using this strong correlation, the arteriolar vasomotor function was quantitatively mapped in
the brain. Decreases in arteriolar vasomotor function of middle-age group were clearly observed especially infrontal, occipital lobe and thalamus.

In this presentation, I am going to talk about my research history during graduate school and post-docs, andintroduce one of my on-going projects.
Glycoblotting, which was invented by Prof. Nishimura at Hokkaido University in 2005, is an excellent
method for glycan analysis. From the principle of glycoblotting, this method can be extended to oxidized lipids,
not only glycans. I am going to show the latest result of an application into lipid analysis.

Diffusion-weighted Magnetic Resonance Imaging:Technical Development and Clinical Applications
Ming-Chung Chou

Department of Medical Imaging and Radiological Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

Diffusion-Weighted Imaging (DWI) is a unique magnetic resonance imaging (MRI) technique that canquantitatively detect and measure molecular diffusion in vivo. It was not until a rapid acquisition, echoplanar imaging, was implemented in MRI scanners, DWI was then popularly utilized clinically to detecttissue alterations and became a standard image for diagnosis of acute ischemic stroke lesions. To accurately
measure water diffusion in three-dimensional space, diffusion tensor imaging (DTI) technique which models
three-dimensional diffusion as an ellipse, was proposed to detect fiber orientations of white matter tissue.
The detected fiber orientations were recently further utilized to construct neuronal fiber tracts by connecting
vectors of neighboring voxels. In clinical application, fiber tracts generated by tractography provided very useful
information for disease diagnosis, tumor surgery as well as disease prognosis after treatment. Moreover, the fiber
tracts were recently utilized to construct so-called brain structural connectivity networks in order to understandhow brain is organized and how the brain was altered in patients with neurological and psychological disorders.
As so much attention has been paid to the applications of brain structural networks, the network measures will
be potentially utilized for disease diagnosis, prognosis, and monitoring the efficacy of treatment. In conclusion,
the diffusion MRI techniques can quantitatively measure water diffusion in vivo and provide unique and usefulmicrostructural information for diagnosis of brain diseases.

34

Nε-(carboxymethyl) lysine Increased Reactive Oxygen Species Production That Induced
Mitochondrial Fission and Mitophagy in Pancreatic beta cells
Horng-Mo Lee

School of Medical Laboratory Sciences and Biotechnology,
College of Medical Science and Technology,
Taipei Medical University, Taipei, Taiwan

Nε-(carboxymethyl) lysine-conjugated bovine serum albumin (CML-BSA) is a major component ofadvanced glycated end-products (AGEs). In the present study we investigated mechanisms by which AGEs
reduce insulin secretion from pancreatic beta cells in pancreatic islets of diabetic db/db mice and in cultured
CML-BSA-treated insulinoma cell line RIN-m5F. We demonstrated that diabetic db/db mouse exhibited anincrease in the number of autophagosomes in damaged mitochondria and receptor for advanced glycation
end products (RAGE). Treatment of db/db mice with alpha-lipoic acid (ALA) for 12 weeks increased thenumber of mitochondria with well-organized cristae and fewer autophagosomes. Treatment of RIN-m5F
cells with CML-BSA reduced mitochondrial membrane potential and ATP production, increased ROS andlipid peroxides production, and caused mitochondrial DNA deletions. CML-BSA also increased the levelof RAGE protein and autophagosome formation, caused mitochondrial dysfunction, and decreased insulin
secretion in RIN-m5F cells. Elevated fission protein dynamin-related protein 1 (Drp1) level and mitochondrial
fragmentation demonstrated the unbalance of mitochondrial fusion and fission in CML-BSA-treated cells.
Additionally, increased levels of Parkin and PTEN-induced putative kinase 1 (PINK1) protein suggest thatfragmented mitochondria were associated with increased mitophagic activity. ALA attenuated CML-BSAinduced mitophage formation in CML-BSA-treated cells. These data suggest that CML-BSA reduced insulin
secretion through mitochondrial fission and mitophagy in pancreatic beta cells.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Evaluation of arteriolar vasomotor function by using MRI

35

Development of Preliminary Occupation-centered Modelin a Korean Elderly Daycare Center

Shih-fen Hsiao

Kyoungmin Lee

Department of Physical Therapy, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

GangWon National University /Far East University, Korea

The world is addressing significant challenges of ageing population with an increase in people requiring acontinuum of healthcare services designed to support their needs to live independently, or to live with chronic
health problems that affect their capacities to perform everyday activities. Dementia is a good example of suchchallenges faced by older people, their care givers, and healthcare professionals. People with dementia does
not only exhibit decline in cognitive but also physical functions, and many of them are also affected by the
behavioral and psychological symptoms of dementia. In order to find out how physical ability may affect theemotional wellbeing and burden of care, we investigated a group of older people from community with (Clinical
Dementia Rating, CDR = 0.5 or 1) or without dementia, for their physical fitness, muscle strength, amount ofphysical activities and level of depression. We found that older people with dementia not only had less physicalactivities but also performed less well in the functional fitness testing. The result of geriatric depression scalealso showed that elderly with dementia was more prevalent with depression, which was significantly correlatedwith their functional fitness and muscle strength. Severity of dementia also linked with worse performance offunctional fitness, muscle strength, and associated with greater burden of caregivers. These results indicate aneed in developing a balanced physical training program for older people with dementia, not only to maintaintheir physical and emotional health but also for decreasing the burden for their caregiver.

Occupational therapists (OTs) have a unique understanding of how occupations impact people’s health andwell-being and thus play a significant role in preventing disabilities and promoting health (Soderback, 2015).
Despite of the increasing number of the aged, the role of OTs in the long-term care insurance system forthe elderly hasn’t established in Korea because of lack of awareness about OT in social welfare setting. The
purpose of this presentation to share an experience to explore the role of the OT in a daycare center under the
Korean long-term care insurance system by developing and managing an occupation-centered service model.
One OT researcher and one OT clinician have developed the occupation-centered model with the support of
Korean Association of Occupational Therapists and Mr. Fujiwara of Dream-lake day service center in Japan
from the February 2015 until June 2016. All service users who have dementia and other geriatric conditions andstaffs at a daycare center have collaborated. Preliminary service model has been drawn up to meet individual
occupational needs of the service users and to enable them to engage in the various daily occupations (Cheong
Choon activities) and monthly special event (Choeng Choon Market). All data were analyzed according to theinteraction of service users (person), activity programs (Occupation), and environment (physical setting andthe personnel in the center). Conclusively, service users could engage in self-determined activities with greater
satisfaction leading to the increase in the number of service users, care workers, and occupational therapists.
The preliminary occupation-centered day care model seemed to prove the power of occupation in this setting.

Therapeutic Use of Occupation in Traditional Chinese Medicine
Li Cong

Department of Occupational Therapy, College of Rehabilitation,
Hiroshima International University, Hiroshima, Japan

In China, occupational therapy was initiated with the support of WHO, Japan and Canada since the 1980s.
On the other hand, for thousands of years, Chinese doctors had tried to choose suitable treatments for patientsfrom herbal medicine, acupuncture and Qigong. However, the occupation activities have not been summarized.
The purpose of this study is to explore and analyze the occupation from thehistoric Traditional Chinese
Medicine. The cases using occupation activity in the Traditional Chinese Medicine references were carefully
searched from 12 commentary books in Chinese and 4 commentary books in Japanese. These cases wereclassified by history era, activity, area and disease, with considering both the theories of Traditional Chinese
Medicine and occupational therapy. As the result, 80 cases were found from 49 classic references authored bydoctors in successive generations. The oldest description is that dance was used to treat the muscle and joint painin the cold Yellow River basin inthe 16th century B.C., which is found in the “Lu ancient Le articles”. Thelatest
one is that a female patient without appetite due to the perceived notion of unpleasant from her husband was
cured by engaging in housework in the Qing dynasty.
These cases are classified by mental health, physical disabilities, developmental disabilities, gerontology andhealthy person. 23 kinds of activities including gardening, music playing, reading and calligraphy were used. In
addition, they can also be classified to self-care, productivity, leisure and others. These cases can be interpreted
by both the Traditional Chinese Medicine and the modern occupational therapy. This study revealed thatoccupation activities have been used for a long time in the Traditional Chinese Medicine.

36

From Ecosystem Health to Planetary Health:
The Development of “Health” as an Ecological Concept

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Physical Fitness, Cognition and Emotional Wellbeing ofOlder Adults with and without Dementia

Hein Mallee

Research Institute for Humanity and Nature,
Kyoto, Japan

There is considerable controversy over how to define the concept of health, but the realization that it carries
a positive connotation beyond the absence of disease has gained ground. Increasingly, “health” is used as a
metaphor to refer to a desirable, “sustainable” state of ecosystems and this broad conceptualization has given rise
to a several vibrant fields of research and action. This includes notions such as ecosystem health, ecohealth, One
Health, and, most recently, planetary health. In most cases, the fields associated with these concepts address bothpeople’s health and the wider ecosystem that influences their health. The presentation will present an overview
of how these different streams of research and action developed, in particular highlighting contributions fromthe humanities and social sciences where applicable. It argues (1) that relatively flexible “buzzwords” play animportant role in bringing together actors from diverse backgrounds in discussions of themes of common
interest, and (2) that the elusive, but generally positive, nature of “health” makes it a fertile metaphor for
discussing issues related to sustainability.

37

- Putting the Pieces Together: Creating A New Era of Health Sciences in Asia July 5, 2019
Faculty of Health Sciences, Hokkaido University
Multipurpose room, E building 1F

Program Schedule
8:20–8:50
8:50–9:00

9:00–10:20

Opening Remarks

Symposium
Session 1

2. Dr. Chien-Chih Ke (Kaohsiung Medical University)
Therapeutic potential of mesenchymal stem cell-derived exosomes

Chair:
Prof. H. Yamaguchi

3. Dr. Chia-Hwa Lee (Taipei Medical University)
Using CRISPR/Cas9 genome editing system in molecular cancer
therapy through in vitro and in vivo models
4. Dr. Torahiko Okubo (Hokkaido University)
Antimicrobial-resistant bacteria and health sciences
Tea Break

10:20–10:40
10:40–12:10
12:10–13:10

13:10–14:30

Poster Session 1

Lunch
5. Dr. Chitanongk Gaogasigam (Chulalongkorn University)
Lower limb muscle activation during quiet stance in hyperextended
knee individuals
Symposium
Session 2

6. Dr. Takako Chikenji (Hokkaido University)
Role of platelet-derived growth factor signaling in synovial fibrosis

Chair:
Prof. H. Maejima

7. Dr. Yeou-Lih Huang (Kaohsiung Medical University)
Speciation of trace elements and its applications in health sciences
8. Dr. Wenjun Ding (University of Chinese Academy of Sciences)
Effects of vanadium compounds on glucose homeostasis and lipid
metabolism in diabetes mellitus
Tea Break9. Dr. Thititip Tippayamontri (Chulalongkorn University)
Mechanistic insights into biological effects of low-dose radiation in
medical radiology

14:30–14:50

14:50–16:10

Symposium
Session 3
Chair:
Prof. M. Ishikawa

16:10–16:30
16:30–18:00
18:00–18:10

38

Registration
Prof. T. Saito (Dean, Faculty of Health Sciences, Hokkaido University)
1. Dr. Denise Shuk Ting Cheung (University of Hong Kong)
Inclusion of telomere length and telomerase activity in outcome
evaluation of lifestyle interventions

Closing Remarks

10. Dr. Akira Sai (Hokkaido University)
The impact of social media on body image in young Malaysian females

Inclusion of telomere length and telomerase activity
in outcome evaluation of lifestyle interventions
Denise Shuk Ting Cheung

School of Nursing, The University of Hong Kong,
Hong Kong, China

Telomeres, which can be thought as analogous to the plastic caps at the ends of shoe laces, cap the ends ofchromosomes and provide protection; and an enzyme, called telomerase, maintains their length. Telomeresshorten over time with each cell division, and the rate of shortening can be increased by chronic stress, leading
to accelerated aging and diseases. Measuring the change in telomere length and telomerase activity can be
useful to evaluate the effect of lifestyle interventions from a cellular perspective. In this presentation, a brief
introduction of telomeres and telomerase will be given. Also, previous lifestyle studies that included telomere
length/telomerase activity in outcome evaluation will be presented.

Therapeutic potential of mesenchymal stem cell-derived exosomes
Chien-Chih Ke

Department of Medical Imaging and Radiological Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

Mesenchymal stem cells (MSCs) have been demonstrated as the promising cell therapy for various human diseases.
Several reports indicate that the major therapeutic effect comes from the paracrine action of transplanted MSCs.
This leads to the recent robust development of using MSC-secreted exosomes or microvesicles (MV) as MSCbased cell-free cell therapy. Exosomes are lipid-membrane bound extracellular vesicles massively produced by
all types of cells and involved in the cell-cell communication. Materials encapsulated in the exosomes, including
DNA, mRNA, microRNA, enzymes and long non-coding RNA (lncRNA), are transported to and regulate thebehavior of recipient cells. MSC-derived exosomes, carrying the factors involved in the paracrine effect, exert
the therapeutic effect through modulating the microenvironment of disease. In this study, we have preliminarily
tested the therapeutic potential in osteoporosis. The results showed the exosomes could be collected from
MSC-conditioned medium and characterized by specific surface marker detection and size measurement. After
treatment of MSC-derived exosomes, mice with ovariectomy-induced osteoporosis showed improved bonemarrow density and elevated osteomarker expression in bone tissue. We found a few important MSC-derived
exosomal microRNAs which are reported to target to the key regulators in osteoporosis. In conclusion, MSCderived exosomes are a promising therapeutic agent in osteoporosis treatment, and holds several advantages ascompared to MSCs. Studies should be carried on to make MSC-derived exosomes a therapeutic strategy forhuman diseases in the future.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The 4th FHS International Conference

11. Dr. Shih-fen Hsiao (Kaohsiung Medical University)
Identification and Intervention of older adults at risk of falling in the community
12. Dr. Sujitra Boonyong (Chulalongkorn University)
Anterior seat inclination and high seat chair could improve sit-to-standperformance in children with cerebral palsy
Break
Poster Session 2
Prof. T. Yamauchi(Chair, Committee on International Affairs, Hokkaido University)

39

Chia-Hwa Lee

School of Medical Laboratory Science and Biotechnology,
TMU Research Center of Cancer Translational Medicine,
Taipei Medical University, Taipei, Taiwan

Although the understanding of tumor malignancy at the molecular level has been largely improved in thepast decades, cancer is still one of the main causes of disease-associated mortality globally. Thus, more effort
is needed to develop new therapeutic tools and approaches exploiting these advances. Recently, the techniquesof clustered regularly interspersed short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas9)
have emerged and become potentially powerful tools in the arsenal of cancer therapy. In our research model,
Cas9 protein and genomic target sgRNA are delivered by lentivirus transfection, which ensures the highest
transfection efficiency in most of the cancer cells. Once sgRNA binds to the target genomic sequence, Cas9 issoon making a DNA double-strand break which automatically triggers DNA repair system in the host cells,
eventually causing indel (inset or deletion) formation on the edited genomic sequence. In our recent study, we
showed epidermal growth factor receptor (EGFR) is predominately expressed in triple negative breast cancer(TNBC), the most malignant type in breast cancer classification. Using CRISPR to target EGFR genome
in MDA-MB-231 (TNBC) breast cancer cells, we found reductions of cancer cell growth both in vitro andin vivo, indicating EGFR as a promising cancer target for TNBC patients. In another cancer therapy model,
chronic myeloid leukemia (CML), we found CRISPR edited ABL DNA locus of Philadelphia chromosome(BCR-ABL) significantly induced apoptosis event in K562 cells (CML cells). A systemic CML animal model
also suggested that using virus to deliver ABL-target CRISPR/Cas9 system significantly inhibited leukemia
cell growth. Furthermore, the leukemia cell population from clinical CML patients demonstrated a significant
cancer cell death when ABL-target CRISPR/Cas9 system was introduced in ex-vivo model. It is worth noting
that, according to our experience, no off-target genetic alterations associated with gene edit model has been
discovered. A CRISPR trial has already begun in Europe to cure beta thalassemia, a blood disorder, by making a
genetic tweak to people’s blood cells. The success of this clinical trial would create a new era for CRISPR-based
cancer therapy.

Antimicrobial-resistant bacteria and health sciences

Antimicrobial-resistant bacteria can easily transfer their resistance gene(s) to other bacteria by conjugation.
Our study revealed that antimicrobial resistance genes are significantly more frequently transmitted from bacteria
to bacteria when we co-culture them with ciliates (a group of protozoa which lives in river and pond water).
Our field work also showed that antimicrobial-resistant bacteria can be isolated from wild damselfly in rivers
and ponds around Sapporo city. These results suggest that antimicrobial resistance genes which were emitted
from hospitals can spread to environmental bacteria, especially in aquatic conditions. To maintain the efficacy of
antimicrobial agents against bacterial infections, we must prevent the spread of antimicrobial-resistant bacteria
not only among human clinical settings but also natural environments.

Lower limb muscle activation during quiet stancein hyperextended knee individuals
Chitanongk Gaogasigam

Department of Physical Therapy, Faculty of Allied Health Sciences,
Chulalongkorn University, Bangkok, Thailand

Background: The study of knee hyperextension on the control of quiet stance ability is scarce. One study
reported that hyperextended knee individuals exhibited lower stance stability than normal knee individuals,
while postural responses were comparable. However, the there is little, if anything, known about neuromuscular
control over the knee joint. The aims of this study were to compare knee joint postural adjustment andneuromuscular control of the knee joint between hyperextended and normal knee individuals.
Methods: The electromyographic activities of seven lower limb muscles and knee joint postural adjustment data
were collected from 36 healthy female participants (18 hyperextended and 18 normal individuals). They wereasked to stand on a firm and foam surface with their eyes open or closed.
Finding: The knee joint postural responses were comparable between groups. It was also found that there was nogroup effect on muscle activity but that standing conditions did show some effect. Both groups demonstrated
an increase in muscle activity as the level of the postural challenge increased. Furthermore, the hyperextended
knee individuals revealed a different muscle activation pattern during standing with eyes closed, especially inthe medial hamstrings muscle.
Interpretation: Knee hyperextended individuals might rely on vision more than normal knee individuals.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Using CRISPR/Cas9 genome editing system in molecular cancer therapy
through in vitro and in vivo models

Torahiko Okubo

Department of Medical Laboratory Science,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Antimicrobial agents such as penicillin and tetracycline are one of the greatest medical tool discovered during
the 20th century. These drugs have been helped millions of patients from diarrhea, pneumonia, urinary tract
infections, and sepsis. However, the emergence and spread of antimicrobial-resistant bacteria have been a global
concern. Some bacteria, such as methicillin-resistant Staphylococcus aureus (knows as MRSA), carbapenemresistant Enterobacteriaceae (including Escherichia coli and Salmonella) or Acinetobacter, are designated as criticalor high-risk pathogens for human health by World Health Organization. These antimicrobial-resistant bacteria
can cause hospital-acquired infection, sometimes fatal to elderly and immune-compromised patients. In Japan,
JANIS ( Japan Nosocomial Infections Surveillance) system monitors the prevalence of antimicrobial-resistantbacteria in hospitals. In this presentation, I will talk about the current situation of antimicrobial-resistantbacteria in mainly Japan using national surveillance data.

40

41

Takako S. Chikenji

Department of Functioning and Disability,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Tissue fibrosis is defined by the deposition of extracellular matrix (ECM), and hyperplasia of resident
mesenchymal cells resulting in induced tissue dysfunction. Synovial fibrosis is commonly observed in patientswith rheumatoid arthritis (RA) and carpal tunnel syndrome are as the primary cause of joint destruction andnerve entrapped, respectively. We have been studied about the mechanism of synovial fibrosis and identified
some therapeutic target.
Research 1. PDGFR signaling mediates fibrosis in carpal tunnel syndrome
Carpal tunnel syndrome (CTS) is the most common compression neuropathy with the incidence reported to be
2–5% in the general population. Progressive fibrosis of sybsynovial connective tissue (SSCT) is associated with
progressive compression and dysfunction of the median nerve, resulting in hand dysfunction. Here we reported
that platelet-derived growth factor receptor alpha (PDGFRα) positive ( + ) cells accumulated in SSCT fibrosis
and the fibrotic response of PDGFRα + cells occur via PI3K/Akt/mTOR signaling pathway.
Research 2. phosphorylated PDGFR signaling mediates fibrosis in RA
RA is a chronic, inflammatory, autoimmune disease that primarily affects the joint destruction associatedwith synovial inflammation. Fibroblast-like synoviocytes (FLSs) in the inflammatory synovium of RA is
known to the primary cause of joint destruction. Here we reported that phosphorylated-PDGFRαβ+ FLSs
accumulated in the sub-lining layer in RA patients and that the presence of PDGF-BB, TGF-β, and TNF-α,
resulted in the activation of anti-apoptotic protein, suppression of cell-cycle inhibitor protein and promote cell
accumulation and hyperproliferation. Cyclin-dependent kinase 4/6 inhibitor and TNF-α inhibitor suppressed
the hyperproliferation and pPDGFRαβ activity, respectively.

42

Effects of vanadium compounds on glucose homeostasis
and lipid metabolism in diabetes mellitus
Wenjun Ding

Laboratory of Environment and Health, College of Life Sciences,
University of Chinese Academy of Sciences, Beijing, China

Our previous studies have demonstrated vanadium and its compounds as potential anti-diabetic agents appear tohave a profound impact on glucose homeostasis and lipid metabolism. However, the molecular mechanisms are notfully understood. We found that Vdipic-Cl treatment significantly improved hyperglycemia and glucose intolerance
in diabetic rats, as well as attenuated the increase in serum and liver triglyceride levels in the mice fed with highfat diet, while significantly increased autophagy induction and activated liver kinase B-1 (LKB1) and adenosine
monophosphate-activated protein kinase (AMPK) phosphorylation in the liver. In vitro results showed that
VOdipic-Cl significantly inhibited lipid droplet formation by increasing the level of conversion and punctuationof microtubule-associated proteins light chain 3 (LC3) in a dose-dependent manner, and activated LKB1 and
AMPK phosphorylation. Confocal microscopy images also showed that VOdipic-Cl induced sequestration of lipid
droplets (LDs) by autophagy. In addition, VOdipic-Cl down-regulated the expression of peroxisome proliferatoractivated receptor (PPARγ), CCAAT element binding protein a (C/EBPα) and sterol regulatory element binding
protein 1c (SREBP-1c), fatty acid synthase (FAS) and fatty acid-binding protein 4 (FABP4) and activated thephosphorylation of acetyl coenzyme A carboxylase (ACC), AMPK and LKB1 in 3T3-L1 preadipocytes. Taken
together, these results suggest that VOdipic-Cl can inhibit preadipocyte differentiation and adipogenesis andreduce hepatic lipid accumulation by inducing autophagy via the activation of LKB1/AMPK-dependent signaling
pathway. These findings will aid our understanding of vanadium compounds with their anti-diabetic properties,
and may provide more selective therapeutic approaches for metabolic syndrome in the future.

Speciation of Trace Elements and its Applications in Health Sciences

Mechanistic insights into biological effects of low-dose radiation
in medical radiology

Yeou-Lih Huang

Thititip Tippayamontri

Department of Medical Laboratory Science and Biotechnology,
College of Health Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

Department of Radiological Technology and Medical Physics,
Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand

To date, most instrumental methods for trace element speciation have been based on the coupling of separation
techniques with sensitive and selective detection systems. Although, liquid chromatography-hyphenatedanalytical systems can be reliable and accurate, various sample pretreatment processes (e.g., filtration, extraction,
deproteinization) are necessary, potentially causing unwanted or unexpected contamination or even changing
the nature of the elemental species. Due to increasing demands for green analytical methods, there is a movetowards the development of miniaturized methods with minimal use of hazardous solvents. In this presentation,
I am going to talk about my experience on biological trace element research and recent work regarding a rapid
and efficient technique for trace element speciation using a desorption free magnetic solid phase extraction
microfluidic system (MSPE), coupled to ICP-MS. Additionally, an effective, continuous, and convenient
sampling method (microdialysis technique) with HPLC/ICP-MS systems to assess the dynamic variations ofoxidative stress biomarker and elemental species in microbe-inoculated culture broth.

Understanding in the biological mechanisms of response to low-dose radiation (LDR) is crucial for evaluating thehealth impacts of ionizing radiation, especially in the expanding field of medical radiology. Although accumulating
evidence indicates that the biological effects of LDR are someway different from those of high-dose radiation,mechanistic insights into biological effects of LDR is still unclear. Thus, the biological effects of LDR exposure
turn into topic of ongoing discussion. LDR induces a variety of DNA lesions. DNA double strands breaks (DSB)
are the most biological significantly, because difficulty repair or absence of repair leads to genomic instability
and cell death. This further induces the risk of developing cancer and toxicities in normal tissues. Therefore,
additional investigation needs in order to evaluate whether of LDR could induce stochastic effects. LDR induces
ROS generation through several molecular pathways. The potential relationship between the accumulation of
ROS and the induction of DSB in the LDR irradiated cells has been described and researched. Moreover,
exposure to LDR may stimulates the cell cycle progression and increase in the production of endogenous ROS
by mitochondria, which potentially lead to mitochondrial dysfunction. Thus, understanding of these interestingmechanisms might illuminate the potential use of low-dose irradiation as a standard treatment regimen.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Role of platelet-derived growth factor (PDGF) signaling in synovial fibrosis

43

Akira Sai

Department of Health Sciences and Technology,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Extensive literature has implicated the role of media in promoting thinness as a societally accepted standardof attractiveness. However, few works have addressed the effects of contemporary media on body image inSoutheast Asian groups, exclusively in one multicultural country. The present study aimed to dismantle how
a range of sociocultural factors influences body image perceptions of modern-day females in Malaysia witha particular focus on social media. Questionnaires were administered to 371 female college students in Kuala
Lumpur who reported how much time spent watching TV, using internet and social media, and how many
people they are connected to on two distinct social media platforms, Facebook and Instagram. The Objectified
Consciousness Scale (OBCS) and Sociocultural Attitudes Towards Appearance Questionnaire-4 (SATAQ-4)
were also assessed to explore the degree of bodily attitudes and internalization of thinness. Bivariate analyses
found ethnic differences between three main ethnic groups, Malays, Chinese and Indians, in relevant body
image areas such as body surveillance, body shame, appearance control beliefs, and pressures from media andfamily. Notably, general linear model analyses indicated that the effects of ethnicity and religion were removed
while exposure to social media, measured by number of friends on Facebook and whom she is following or
being followed by on Instagram, was explicitly found to be a significant predictor. The present findings showthat social media exposure plays a considerable part in young females’ body image despite of ethnic differences,highlighting the need for international attention to multidimensional aspects of the current media.

Identification and Intervention of Older Adults
at Risk of Falling in the Community

Anterior Seat Inclination and High Seat Chair Could Improve Sit-to-Stand
Performance in Children with Cerebral Palsy
Sujitra Boonyong

Department of Physical Therapy, Faculty of Allied Health Sciences,
Chulalongkorn University, Bangkok, Thailand

Background: Anterior seat inclination (AI) and high seat chair (HiS) has been applied in children with spastic
diplegic cerebral palsy (SDCP) to adjust alignment during sitting. However, there has been a lack of evidence
reporting the effects of AI and HiS on sit-to-stand (STS) performance in children with SDCP. Therefore, theaim of the study was to determine whether AI and HiS could improve STS performance in children with SDCP.
Methods: Twelve children with SDCP (GMFCS I-II) and twelve age- and gender-matched control TD
children were enrolled. All participants performed STS with horizontal seat (HS). Then, children with SDCP
randomly performed STS with AI and HiS. Three-dimensional motion analysis system was used to capture
STS movements.
Finding: Children with SDCP took a longer time and used more mechanical work during STS than TD children.
In addition, children with SDCP presented more trunk, hip, and knee flexion, and less ankle dorsiflexion during
STS. Moreover, the peak vertical ground reaction force, maximum hip, knee extension moment, and plantar
flexion moment in children with SDCP were asymmetrical between the dominant and non-dominant leg.
Using AI and HiS during STS in children with SDCP could reduce the movement time and mechanical work.
However, the movement time in both AI and HiS conditions still higher than those in TD children.
Interpretation: AI and HiS could help children with SDCP to improve STS performance.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The Impact of Social Media on Body Image in Young Malaysian Females

Shih-fen Hsiao

Department of Physical Therapy, College of Health Sciences,
Kaohsiung Medical University, Kaohsiung, Taiwan

Taiwan has become ‘aged’ in 2018, and will become a super-aged society in 2025, when the population of theelderly is over 20%. Frailty or falls in the elderly often leads to hospitalization, disability or bedridden. Successful
implementation of evidence from frailty and fall prevention studies would improve quality of care and promotehealthy aging as well as diminish the impact of aging on health care systems. We examined community elderly
utilizing the 28 Kaohsiung Community-based Care Centers during 2017–2018 to find if they could be benefited
from a physical therapist-led, multi-domain intervention for integrated balance and fitness training. In total 598
elderlies completed the tests and exercise programs. They were further categorized as high risk of falling (n=368)
and low risk of falling (n=230) groups, and sub-grouped according to the age. Most of the elderly were classified
as having risk of falls with the 2.44m Up-and-Go Test in all age groups during the baseline testing. There wassignificant improvement in 30-second chair-stand, 2.44m Up-&-Go test, single-leg stance, total number of risk
factors and cognitive performance in those with high fall risk, but the improvement was limited in the oldestold group. Based on the results, one-hour per week, multi-domain intervention including exercise component
seem to be promising. We also advocate intervening proactively for those healthy elderly to prevent developing
risk of falls or frailty with a multidisciplinary collaborative approach.

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45

Approach to Understand and Prevent Ankle Injuries

September 17–18, 2021

Cheng-Feng Lin- Look for the Silver Lining in the Post-Pandemic Health Sciences Online via Zoom & Slack

Program ScheduleDay 1 Sept. 17, 2021 (Fri)11:00–11:10

11:10–12:10

Opening Remarks

Symposium
Session 1
Chair:
Prof. T. Chikenji

12:10–13:10
13:10–14:10
14:10–15:10
15:10–15:30

15:30–16:30

Symposium
Session 2
Chair:
Prof. A. Ikeda-Araki

Symposium
Session 3
Chair:
Prof. T. Yamauchi

46

3. Dr. Qian Liu (Second Xiangya Hospital of Central South University)
Engineered tendon-fibrocartilage-bone composite and bone marrowderived mesenchymal stem cell sheet augmentation promotes rotator
cuff healing in a nonweight-bearing canine model
Break
Break
4. Dr. Polly Wai-Chi Li (The University of Hong Kong)
Creating a virtual heart attack experience to prepare patients in
responding to heart attack symptoms

The Different Effects on Motor Learning for Postural Control
Using Visual and Auditory Biofeedback Training

6. Dr. Hien Thi Thu Ngo (Thang Long University)
Environmental pollution and potential health effects of exposure to
e-waste in Vietnam: A short review

Naoya Hasegawa

7. Dr. Sikopo Nyambe (Hokkaido University)
Examining the water, sanitation and hygiene ecosystem in peri-urban
Lusaka, Zambia through photovoice
8. Dr. Yung-Feng Lin (Taipei Medical University)
Studies on blood-based biomarkers of Alzheimer’s disease
9. Dr. Takaaki Yoshimura (Hokkaido University)
Urethra-sparing intensity modulated proton therapy for localized
prostate cancer with non-invasive urethra visualization method

Poster Discussion for Poster Session 2

Closing Remarks

Ankle injuries are very common in athletes, and the unstable ankle affects not only their daily activities but also
movement quality and performance. In addition, fatigue during sports may lead to injury. Thus, our lab evaluatedthe movement pattern of athletes to identify potential risk factors as well as training program to reduce themovement error or inappropriate movement pattern. Therefore, athletes with or without functional ankle
instability (FAI) were recruited for different studies. A motion capture system along with forceplates were used
to evaluate the biomechanical factors during static and dynamic movements. An electromyography system wasused to identify muscle firing pattern. Ankle joint reposition sense was also evaluated. Ankle brace and kinesio
tape were also applied for evaluation of their effectiveness on movement correction after fatigue. For training
effect, six-week training programs were designed for athletes with FAI. Furthermore, a three-dimensional bikepedal was designed to facilitate ankle motion during pedaling and a 6-week pedaling training was applied inathletes with FAI.
In our findings, the remodeled bicycle pedal training and integrated training program reduced absolute
error in either plantar flexion angle or inversion angle, decreased inversion angle at impact, increased overall
ankle stability with increased co-contraction index, and should be considered for athletes with FAI to restore
the proprioception and static and dynamic movement control. Furthermore, ankle braces might affect shock
absorption during landing with a more extended knee while kinesio tape may be effective for the posturalcontrol during landing.

5. Dr. Michiko Yoshida (Hokkaido University)
Comprehensive analysis of childcare-related factors affecting infant
sleep development: effects of light stimulation and co-sleeping

10. Dr. Anussara Prayonggrat (Chulalongkorn University)
Studies on selective use of proton therapy in primary liver cancers using
normal tissue complication probability model
Break
Shotgun Presentation of Poster Session 2

12:20–13:20
13:20–14:20
14:20–15:20
15:20–15:30

2. Dr. Naoya Hasegawa (Hokkaido University)
The different effects on motor learning for postural control using visualand auditory biofeedback training

Shotgun Presentation of Poster Session 1
Poster Discussion for Poster Session 1

Day 2 Sept. 18, 2021 (Sat)11:00–12:20

Prof. H. Date
(Dean, Faculty of Health Sciences, Hokkaido University)
1. Dr. Cheng-Feng Lin (National Cheng Kung University)
Approach to understand and prevent ankle injuries

Department of Physical Therapy, College of Medicine,National Cheng Kung University, Tainan, Taiwan

Prof. T. Yamauchi(Chair, Committee on International Affairs, Hokkaido University)

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

The 5th FHS International Conference

Department of Rehabilitation Science,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Postural control is impaired with aging and with neurological disorders. Specifically, postural instability withsome neurological disorders is notoriously difficult to treat, and that are not often cured by pharmacologicalor surgical treatment. By contrast, there is evidence that physical training can improve the postural stability.
Therefore, it is important for physical therapists to choose effective method of the training on postural control.
Augmented sensory biofeedback (BF) for postural control is widely used to improve postural stability. Most
previous studies of postural control using sensory BF have used visual BF during quiet stance. However, posturalcontrol includes several balance domains: anticipatory postural adjustments, automatic postural responses,
postural sway during quiet stance, voluntary postural sway, and gait. In addition, visual BF increased performance
during acquisition, but not during retention tests (learning effects). On the other hand, the field of BF training
has taken advantage of technological advances, and as technology continues to progress more options will beavailable for physical therapists such as consecutive or discreet auditory or somatosensory BF training. However,
the effective sensory information in BF systems of motor learning for postural control is still unknown.
This lecture will present recent research on the effects of BF training on postural control in healthy young
adults, focusing on investigating the learning effects of visual versus auditory BF training.

47

Qian Liu

Department of Orthopaedics,
Second Xiangya Hospital of Central South University,
Changsha, China

Reducing rotator cuff failure after repair remains a challenge due to suboptimal tendon-to-bone healing. In
this study we report a novel biomaterial with engineered tendon-fibrocartilage-bone composite (TFBC) andbone marrow-derived mesenchymal stem cell sheet (BMSCS); this construct was tested for augmentation ofrotator cuff repair using a canine non-weight-bearing (NWB) model. A total of 42 mixed-breed dogs wererandomly allocated to 3 groups (n=14 each). Unilateral infraspinatus tendon underwent suture repair only(control); augmentation with engineered TFBC alone (TFBC), or augmentation with engineered TFBC andBMSCS (TFBC+BMSCS). Histomorphometric analysis and biomechanical testing were performed at 6 weeks
after surgery. The TFBC+BMSCS augmented repairs demonstrated superior histological scores, greater new
fibrocartilage formation and collagen fiber organization at the tendon-bone interface compared with the controls.
The ultimate failure load and ultimate stress were 286.80 ± 45.02 N and 4.50 ± 1.11 MPa for TFBC+BMSCS
group, 163.20 ± 61.21 N and 2.60 ± 0.97 MPa for control group (TFBC+BMSCS vs control, P=1.12E-04 and0.003, respectively), 206.10 ± 60.99 N and 3.20 ± 1.31 MPa for TFBC group (TFBC+BMSCS vs TFBC, P=0.009
and 0.045, respectively). In conclusion, application of an engineered TFBC and BMSCS can enhance rotator cuff
healing in terms of anatomic structure, collagen organization and biomechanical strength in a canine NWB model.
Combined TFBC and BMSCS augmentation is a promising strategy for rotator cuff tears and has a high potential
impact on clinical practice.

Creating a Virtual Heart Attack Experience to Prepare Patientsin Responding to Heart Attack Symptoms
Polly Wai-Chi Li

School of Nursing, The University of Hong Kong,
Hong Kong, China

in the intervention group had significant improvements in attitudes and beliefs about care seeking for AMI
symptoms at all time-points than those in the control group (p = <0.001–0.017). Among the participants withanother AMI attack during the study period, those in the intervention group showed a significant reduction inprehospital delay time than the control group (p = 0.031), and no between-group difference was found for theuse of ambulance.
This study demonstrates the favorable effects of the modelling-based narrative intervention in optimizingcare-seeking behaviors in AMI patients.

Comprehensive Analysis of Childcare-Related Factors Affecting
Infant Sleep Development: Effects of Light Stimulation and Co-Sleeping
Michiko Adachi-Yoshida

Department of Comprehensive Development Nursing,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

The purpose of this study was to comprehensively evaluate childcare-related factors such as light stimulationand nighttime co-sleeping which may affect infant sleep development. The subjects were infants aged 3-5months. The amount of sleep and light stimulation was monitored for four days using an actigraph. Additionally,mothers were asked to complete a sleep diary and questionnaire about childcare-related factors. Among thechildcare-related factors, strong influences were light stimulation and nighttime co-sleeping. The amount oflight stimulation during the daytime was inversely correlated with the extent of sleep during the daytime, andlight stimulation during the nighttime was inversely correlated with both the extent of total sleep and the extent
of active sleep during the nighttime. Co-sleeping infants slept significantly less during the daytime (12.1%
vs. 15.2%, p = 0.001) and significantly more during the nighttime (38.8 % vs. 36.5%, p = 0.001) compared toinfants who slept alone. These results suggest that an environment with more light stimulation during the day
and less light stimulation at night may promote the development of circadian rhythms in infants. Further, cosleeping at night may reduce the proportion of daytime sleep and increase the proportion of nighttime sleep,
thereby promoting sleep consolidation at night. This is a new finding on infant sleep. In recent years, co-sleeping
has been regarded as a risk factor for SIDS and SUID, however, the results of this study reveal additional new
benefits of co-sleeping for infants. The effects of co-sleeping are not yet fully revealed. Therefore, the risks andbenefits need to be examined without preconceptions.

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Engineered Tendon-Fibrocartilage-Bone Composite andBone Marrow-Derived Mesenchymal Stem Cell Sheet Augmentation
Promotes Rotator Cuff Healing in a Non-Weight-Bearing Canine Model

Delay in seeking treatment for acute myocardial infarction (AMI) persists to be the most significant hinderingfactor for effective AMI management. Previous interventions are brief and didactic in nature, rendering themineffective in shortening the time delay in care-seeking.
A randomized controlled trial (N = 285) was conducted to evaluate the effects of a modelling-based narrativeintervention in patients with a history of AMI. The participants were randomized to receive either the tested
intervention or didactic education as control. The modelling-based narrative intervention comprised groupbased interactive sessions to engage participants in mental rehearsal of the perceptual-cognitive processes inrecognizing and responding to AMI symptoms, while the control intervention consisted of factual information
about AMI to be delivered with a traditional didactic approach. Generalized estimating equation modeling wasused for data analysis.
There were no between-group differences in changes of AMI knowledge over the baseline and 3- or
12-month time-points, such difference became significant at 24-month time-point (p = 0.042). Participants

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49

Hien Thi Thu Ngo

Department of Public Health, Faculty of Health Sciences,
Thang Long University, Hanoi, Vietnam

E-waste contains a unique combination of persistent organic compounds and about 60 chemical elements, manyof which are potentially hazardous. Inappropriate handlings of informal e-waste processing have increasingly
become an environmental and public health issue of concern in Vietnam. A large amount of e-waste wascollected and dismantled by the informal private sector, using a simple, manual process to recover only a fractionof precious metals or plastics, and then dispose of or export the remaining parts. Processing e-waste had notbeen specifically regulated by Vietnamese government. Numerous studies elucidated the current levels ofcontaminants associated with various types of e-waste processing such as persistent organic pollutants including
polybrominated diphenyl ethers, brominated and chlorinated flame retardants, chlorinated and brominateddioxins, and dioxin-like compounds, and heavy metals derived from informal processing area of e-waste in
Vietnam. Exposing to multiple toxic substances via different environmental media and pathways may cause
aggregative health effects to humans, particularly levels of blood metals, DNA damage, carcinogenic and noncarcinogenic risks found in exposed children were significantly higher than those in reference children. This
short review highlighted the importance of release mitigation of hazardous substances from informal e-waste
processing facilities to prevent their potential environmental health effects on humans.

Examining the Water, Sanitation and Hygiene Ecosystem
in Peri-Urban Lusaka, Zambia Through Photovoice
Sikopo Nyambe

Department of Health Sciences and Technology,
Faculty of Health Sciences, Hokkaido University, Sapporo, JapanIn Zambia, 11.4% of all deaths are related to inadequate access to water, sanitation and hygiene (WASH),
with frequent disease outbreaks emanating from peri-urban settlements. Despite these outbreaks, few studies
have explored the factors that maintain the peri-urbans poor WASH health environment. This study aimed to
explore the WASH ecosystem from the viewpoint of resident youth by identifying maintaining factors throughecological theory. It was conducted in two peri-urban settlements in Lusaka, Zambia. Our participants (n = 16,age = 17–24 years) took part in a photovoice exercise, in which they used photographs to answer the question:‘What is WASH in your community?’ Data underwent theoretical thematic analysis after contextualization,brief codifying and participant poster creation.
Participant results defined peri-urban WASH under four themes within ecological theory: Poor practice(intrapersonal, interpersonal), Health hazard (community norm), Substandard and unregulated (public policy,organizational), and Offering hope for change (intrapersonal, interpersonal). Participant findings highlighted
a gap at community level: public policy level standards, regulations and implementations had minimal impact
on peri-urban WASH and public health at community, inter- and intrapersonal levels due to poor community
engagement and an inconsideration of the WASH realities in high density areas. Our study showed the importanceof co-research and co-design of interventions with community members, with participants recommending
increased government-resident collaboration to empower residents in WASH and overall peri-urban health.

50

Studies on Blood-Based Biomarkers of Alzheimer’s Disease
Yung-Feng Lin

School of Medical Laboratory Science and Biotechnology,
Taipei Medical University, Taipei, Taiwan

Alzheimer’s disease (AD) is the most common form of dementia worldwide. Currently established biomarkers
of AD from cerebrospinal fluid and neuroimaging can be valuable; however, barriers to efficient, cost-effective
clinical execution exist. The development of blood-based biomarkers for early diagnosis and treatment of AD isdesirable. Serum samples from AD or health control Taiwanese were collected from Taipei Medical University
Hospital or Taipei Medical University Joint Biobank. Specific proteins were analyzed with immunoblotting
and ELISA to identify potential AD biomarkers, or immunoprecipitated for LC-MS/MS to identify ADspecific post-translational modifications. Abelson helper integration site-1 (AHI1), a facilitator of intracellularcargo translocation to inhibit amyloidogenic pathology of AD, was reduced in AD model cells, mouse brain
and patient’s serum, suggesting that AHI1 is a promising AD biomarker. In the clinical chemistry tests, fasting
glucose was statistically higher in AD patients than in control subjects. In addition, it has been reported that
hyperglycemia can promote the production of reactive oxygen species and advanced glycation end products,
leading to lipid peroxidation and neurodegeneration. Indeed, LC-MS/MS and immunoblotting analyses
identified Nε-(Carboxyethyl)lysine (CEL) and 4‐hydroxynonenal (HNE) adducts significantly increased in AD
serum. The levels of specific autoantibodies IgG and IgM against these adducts were also changed depending on
the disease progression. Thus, AHI1 protein, adducts of CEL and HNE as well as responding autoantibodies
may be good biomarkers for AD diagnosis and treatment.

Urethra-Sparing Intensity Modulated Proton Therapy for localized prostate Cancer
with Non-invasive Urethra Visualization Method

1st Conference / 2nd Conference / 3rd Conference / 4th Conference / 5th Conference

Environmental pollution and potential health effects of exposure
to e-waste in Vietnam: A short review

Takaaki Yoshimura

Department of Health Sciences and Technology,
Faculty of Health Sciences, Hokkaido University, Sapporo, Japan

Prostate cancer is the most frequent diagnosed cancer in over one-half of the countries of the world and has
multiple treatment options. The basic goals of radiotherapy for prostate cancer are maximizing the disease
control and minimizing both acute and late side effects. These are depending on the dose to tumor and normal
tissue. Currently, urethra-sparing radiation therapy has been considered to minimize genitourinary toxicity
by identified urethra with catheter insertion and intentionally underdosing the periurethral transitional zone.
However, this procedure is not only invasive but also may increase patient discomfort, the risk of infection, andthe risk of iatrogenic urethral strictures. We have developed non-invasive urethra visualization methods using
post-urination magnetic resonance image (PU-MRI) without using catheter. This study aimed to investigate
the clinical impact of urethra-sparing intensity modulated proton therapy (US-IMPT) plan compared toconventional clinical plans without urethral dose reduction. To evaluate the clinical impact of the US-IMPT
plan compared to the clinical plan, tumor control probability (TCP) for clinical target volume (CTV) andnormal tissue complication probability (NTCP) for rectum, bladder and urethra were calculated. The NTCP
value for urethra in US-IMPT plan was significantly lower than that in the clinical plan, while maintaining
the same level of TCP in CTV and NTCP in other organs. Thus, the US-IMPT with PU-MRI has potential
clinical advantages in reducing the risk of genitourinary toxicities.

51

Studies on Selective Use of Proton Therapy in Primary Liver Cancers
Using Normal Tissue Complication Probability Model
Anussara Prayongrat

Department of Radiation Oncology, Chulalongkorn University,
Bangkok, Thailand

Liver cancer is a common cancer and cause of cancer deaths around the world. Radiotherapy is one of themainstay treatments but might induce liver toxicity. Proton therapy is an emerging radiotherapy technology
to improve tumor control and minimize toxicity, by giving higher dose to tumor while lower dose to normalliver. However, the obstacles are limited availability and high cost of proton therapy. Therefore, it is important
to appropriately select patients for proton therapy. Normal tissue complication probability (NTCP) model is atool to translate radiation dose into clinical risk or toxicity. Challenges include multifactorial effects which resultin uncertainty of the NTCP model, for example, heterogeneous patient population and baseline characteristics,
small sample size, and difference in treatment protocol. Our studies focused on the NTCP model to predict
radiation-induced liver toxicity. Apart from the radiation dose, baseline patient characteristics were integrated in
the model for an individual use. The model uncertainty was assessed by statistical and computational methods,
resulting in toxicity risk with a range of confidence interval. Finally, the toxicity risk reduction from proton
therapy, compared with standard x-ray treatment, was estimated together with confidence interval. Patients with
sufficient risk reduction will be a candidate for proton therapy. This is called NTCP model-based approach toselect patients for proton therapy. Estimation of the model uncertainty possibly improved the reliability of thisapproach. Further studies on more sophisticated analysis such as machine learning and validation of the NTCP
model-based approach are required.

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Presenting author | M/D year | Major, Institute | Poster title

5– 2
021

2015 (2nd Conference)

Tomohiro Yamazaki

D3

Advanced Medical Sciences,
GSHS, HU

In silico prediction of novel effectors secreted by typeIII secretion apparatus of pathogenic chlamydiae

Jihun Kwon

M2

Biomedical Science andEngineering, GSHS, HU

Application of gold nanoparticles as a radio sensitizer:
comparison between protons and X-rays

Ryodai Yamamura

M2

Health Research Studies,
GSHS, HU

Lifestyle and bowel habits in female college students:
Risk of the pre-constipation group2017 (3rd Conference)
Kyungshil Kim

D3

Comprehensive Health
Sciences, GSHS, HU

Effect of exposure to short-wavelength light onsusceptibility to motion sickness

Junko Hasegawa

D2

Comprehensive Health
Sciences, GSHS, HU

Development of a screening tool to Predict malnutrition
among children under two years old in Zambia

Kensuke Shirasawa

M2

Medical Laboratory Science,
GSHS, HU

Increase of Lysophosphatidylinositol in Liver Graftduring Cold Preservation

2019 (4th Conference)
Tamao Miyao

M2

Biomedical Science andEngineering, GSHS, HU

Radio-Sensitivity of the Cells Exposed to Ionizing
Radiations Considering the Bystander Effect

Zijun Gao

M1

Health Research Studies,
GSHS, HU

Determination of the Levels of Polycyclic Aromatic
Hydrocarbons (PAHs) in Seafood and Testing the
Binary Effects of Total 4-PAH on HepG2 Cells

2021 (5th Conference)
Shan Yun

D3

Comprehensive Health
Sciences, GSHS, HU

Factors Predicting Occupational Dysfunction in
Community-Dwelling Older Adults

Yi Zeng

D1

Comprehensive Health
Sciences, GSHS, HU

Associations Between Hygiene Practices and Fecal
Contamination in the Household Environment ofChildren in a Suburban Area of China

Ryuichiro Ueda

M2

Health Research Studies,
GSHS, HU

COVID-19 and Public Opinion: A Sentiment
Analysis of Twitter Users in Japan* GSHS, HU: Graduate School of Health Sciences, Hokkaido University

52

53

Analyses of
FHS International Conferences
SOUTH KOREA

Trends & Transitions

CHINA

JAPAN

HONG KONG
THAILANDTAIWANVIETNAM

Overview of the Number of Presentations

The

numbers of presentations at theFHS International Conferences

held in 2013, 2015, 2017, 2019, and 2021 were12, 43, 86, 89, and 95, respectively; after a
sharp increase from 2013 to 2017, the number
remained at around 90 at the three most recent
conferences (Figure 1). The increase was due tothe rise in the number of student presentations
since 2015 despite the number of invited
presentations remaining constant at around 10.

Symposium presentations

Student presentations

INDONESIA

100
80
60

Figure 2. Countries and regions of the institutes of FHS invited
speakers. One star represents one speaker. The green stars are thosefrom Hokkaido University (HU) alongside the purple stars from HU’s
MOU partner universities and the blue stars from other institutes.

40
20
0

2013

2015

2017

2019

2021

Figure 1. Total number of presentations

University, and one from National Cheng Kung University. Following the above countries, we had six
speakers from Chulalongkorn University in Thailand. Indonesia followed Thailand with four invited
speakers who all belonged to Diponegoro University/Dr. Kariadi Hospital. In addition to that, two speakers

One

54

from the University of Hong Kong took part in past FHS meetings, and so did our two colleagues from theof the main components of the presentations at FHS conferences is symposiums. In

University of Chinese Academy of Sciences and the Second Xiangya Hospital of Central South University

2013 and onwards, around 10 presentations were given by invited speakers at eachin China. Last but not least, we had one guest speaker from Thang Long University in Vietnam. On that

conference meeting. Figure 2 shows the distribution of speakers by institute location. In total, there

note, the Faculty of Health Sciences has signed a Memorandum of Understanding with each of the said

were 51 presentations given across five conferences. The largest number (19) among all presentations

five institutes with which the highest numbers of invited speakers per institute correlate—Taipei Medical

came from Japan. Sixteen presentations among those were given by speakers from the host institute,

University, Kaohsiung Medical University, Chulalongkorn University, Diponegoro University/Dr. Kariadi

Hokkaido University, along with invited speakers from the University of Tokyo, Hiroshima International

Hospital, and the University of Hong Kong—their active contribution and collaboration have been very

University and Kyoto Prefectural University. The second majority of the speakers were from Taiwan

much appreciated. We hope to welcome more diverse lectures on invitation from a variety of countries

with 16 presentations – eight speakers from Taipei Medical University, seven from Kaohsiung Medical

and regions in the future.

55

Another

9 presentations by Rehabilitation Science. The accumulation to date classified in master’s programs

main component of the
Master Course

presentations was thegraduate students’ poster presentations first introduced

Doctor Course

100

Studies as the runner-up with 41, followed by Medical Laboratory Science with 28, Rehabilitation
Science with 23, Advanced Public Health Nursing with 19, Nursing Science with 15, Advanced Midwifery80

in 2015. As shown in Figure 3, the number ofpresentations made by the Graduate School of Healthwith 15, and Advanced Practice Nursing with 1.

60

Sciences students increased between 2015 and 2021

prescribes Biomedical Science and Engineering as the highest in number with 48, Health Research40

rising from 30 to 66, 71 then 79, respectively. Overall,there were more presentations by master course

16

20

students than those by doctoral course students. The

0student presentations from other graduate schools
between 2015 and 2021 were 3, 10, 6, and 6 in number,

14

2015

2017

2019

2021

Medical Laboratory Science10

Figure 3. Total number of student
presentations by graduate course

respectively.

Biomedical Science and Engineering

12

Rehabilitation Science

8

Nursing Science

6

Advanced Practice Nursing
Advanced Midwifery

4In2021, the number of presentations by doctoral students increased to 25. The breakdown by

2

doctoral course program (Nursing Sciences, Comprehensive Health Sciences, and Advanced

0

Health Research Studies

2015

Medical Sciences) was 6, 11, and 8, respectively (Figure 4). The accumulation to date classified in theabove programs prescribes the Comprehensive Health Sciences as the highest in number with 36

Advanced Public Health Nursing

2017

2019

2021

Figure 5. Total number of student presentations by master’s course program

presentations, followed by 11 by the Advanced Medical Sciences and 9 by the Nursing Sciences.

16

Word Cloud of the Research Titles

14
12
10
8
Nursing Sciences

6

Comprehensive Health Sciences

4A

word cloud of the research titles collected from the 1st–5th FHS International Conferences. The
high-frequency words unique to the titles of the presented research papers include “health”,“cells”, “older”, “adults”, “Japan”, “patients”, and “children”.

Advanced Medical Sciences

2
0
2015

2017

2019

2021

Figure 4. Total number of student presentations by doctoral course programThe

number of presentations made by master’s course students has been at around 60 inrecent years: 23 in 2015, 52 in 2017, 61 in 2019, and 54 in 2021. As shown in Figure 5, at

the most recent conference in 2021, the highest number of presentations was 15, shared by the master’s
programs of Biomedical Science and Engineering and Health Research Studies which was followed by

56

57

The FHS International Conference
Organizer

International Affairs Office

Faculty of Health Sciences, Hokkaido University

1st FHS: Tadayoshi Asaka, Junji Matsuo, Makiko Noguchi, Shinya Sakai, Mina Samukawa,
Miho Sato, Naomi Sumi, Kaori Tsutsumi, Taro Yamauchi
2nd FHS: Tadayoshi Asaka, Junji Matsuo, Makiko Noguchi, Shinya Sakai, Mina Samukawa,
Miho Sato, Naomi Sumi, Kaori Tsutsumi, Taro Yamauchi
3rd FHS: Tadayoshi Asaka, Hiroyuki Date, Junji Matsuo, Makiko Noguchi, Shinya Sakai,
Mina Samukawa, Miho Sato, Risa Takashima, Kaori Tsutsumi, Taro Yamauchi, Yuko Yoshida
4th FHS: Michiko Aoyanagi, Takako Chikenji, Hiroyuki Date, Torahiko Okubo,
Takeshi Saito, Shinya Sakai, Mina Samukawa, Miho Sato, Risa Takashima, Kaori Tsutsumi,
Hiroko Yamashina, Taro Yamauchi, Yuko Yoshida
5th FHS: Michiko Aoyanagi, Atsuko Araki, Tadayoshi Asaka, Hiroyuki Date,
Takako Chikenji, Naoya Hasegawa, Torahiko Okubo, Mina Samukawa, Miho Sato,
Risa Takashima, Taro Yamauchi, Michiko Yoshida, Takaaki Yoshimura

Faculty of Health Sciences, Hokkaido University
Our partners

Faculty of Medicine, Diponegoro University & Dr. Kariadi Hospital, Indonesia
Faculty of Medicine & Faculty of Allied Health Sciences, Chulalongkorn University, Thailand
Taipei Medical University, Taiwan (Inter-university)
College of Health Sciences, Kaohsiung Medical University, Taiwan
School of Nursing, University of Hong Kong, China

A Decade of Health Sciences in Asia:
Looking Back at the FHS International Conference
Edited by International Affairs Office, Faculty of Health Sciences, Hokkaido University
Michiko Aoyanagi, Takako Chikenji, Hisanori Fukunaga, Naoya Hasegawa, Atsuko Ikeda, Torahiko Okubo,
Mina Samukawa, Tomoko Sasaki, Miho Sato, Risa Takashima, Taro Yamauchi, Michiko Yoshida, Takaaki Yoshimura