1 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

SECTION 1

2017/4/7
2024/3/15

Chemicals and company identification

Product name

ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

Product code

EH10

Company nameCANON OPTRON INC.

Address

1744-1, Kanakubo, Yuki-shi, Ibaraki-ken, 307-0015 Japan

Section nameSales Department

Telephone number+81-296-21-3700

Fax number+81-296-21-3770

Emergency telephone tumber+81-296-21-3700

Use

Vacuum deposition material

SECTION 2

Date of Issue
Revised Date

Hazards identification

GHS Classification （A classification by JIS Z 7252 "classification methods such as chemical substances based on GHS"）
Physical hazards

Explosives

Classification not possible

Flammable gases

Not applicable

Aerosols

Not applicable

Oxidizing gases

Not applicableGas under pressure

Not applicable

Flammable liquids

Not applicable

Flammable solids

Classification not possible

Self-reactive substances and mixtures

Classification not possible

Pyrophoric liquids

Not applicable

Pyrophoric solids

Classification not possible

Self-heating substances and mixtures

Classification not possible

Substances and mixtures which,inClassification not possible
contact with water,emit flammable gases

Health hazards

Oxidizing liquids

Not applicable

Oxidizing solids

Classification not possible

Organic peroxides

Classification not possible

Corrosive to metals

Classification not possible

Desensitize explosives

Classification not possible

Acute toxicity(oral)

Classification not possible

Acute toxicity(dermal)

Classification not possible

Acute toxicity (Inhalation: Gases)

Not applicable

Acute toxicity (Inhalation: Vapors)

Classification not possible

2 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Environmental hazards

Date of Issue
Revised Date

Acute toxicity (Inhalation: Dusts andmists)Classification not possible

Skin corrosion/irritation

Classification not possible

Serious eye damage/eye irritation

Classification not possible

Respiratory sensitization

Classification not possible

Skin sensitization

Classification not possible

Germ cell mutagenicity

Classification not possible

Carcinogenicity

Classification not possible

Reproductive toxicity

Classification not possible

Reproductive toxicity, effects on or via
lactation

Classification not possible

Specific target organ toxicity(single
exposure)

Category 2

Specific target organ toxicity(repeatedexposure)

Category 1

Aspiration hazard

Classification not possible

Hazardous to the aquatic environment
Short-term(acute)Classification not possible

Hazardous to the aquatic environmentLong-term(chronic)

Classification not possible

Hazardous to the ozone layer

Classification not possible

Label elements
hazard Pictograms

Health Hazard

健康有害性Signal word

DangerDangerous goods hazard
information

May cause damage to organs Lungs.
Causes damage to organs through prolonged or repeated exposure Lungs.

Precautionary statements【Safety measures】

Do not breathe dust/fume/gas/mist/vapours/spray.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.

2017/4/7
2024/3/15

3 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

SECTION 3

Date of Issue
Revised Date【First-aid measures】

If exposed or concerned：Call poison center or doctor/physician.
Get medical advice/attention if you feel unwell.
Specific treatment.

【Storage】

Store locked up.

【Disposal】

Dispose of contents/container in accordance with national regulations.

【Other hazards】-

Composition/information on ingredients

Substance/Mixture

MixtureChemical name

Hydroxylapatite

Cerium oxide

Chemical formula

Ca5(PO4)3(OH)CeO2Concentration or concentration
range

Ca5(PO4)3(OH) : 75-85%
CeO2 : 15-25%
Total = 100%

CAS No.

1306-06-5

1306-38-3

TSCA Inventry

Hydroxylapatite (Ca5(OH)(PO4)3)

Cerium oxide (CeO2)

EINECS number

215-145-7

215-150-4

Radioactive information

Radioactive substances are not used as the material. Therefore, there is no
reason that ionizing radiation would be generated.

SECTION 4

2017/4/7
2024/3/15

First aid measures

Inhalation

Remove person to fresh air and keep comfortable for breathing.
Get medical advice/attention if you feel unwell.

Skin contact

Take off immediately all contaminated clothing. Rinse affected areas withwater/shower.
IF ON SKIN：Wash with plenty of soap and water.
If skin irritation or rash occurs: ：Get medical advice/attention.

Eye contact

Rinse cautiously with water for several minutes.Remove contact lenses, if present
and easy to do. Continue rising.
If eye irritation persists：Get medical advice/attention.

Ingestion

Rinse mouth.
Get medical advice/attention.

Most important symptoms andeffects, both acute and delayed

No data available

Protection of first aiders

Rescuers, wear suitable protective equipment as the situation demands.

Special precautions for physicians

No data available

SECTION 5

Firefighting measures

Suitable extinguishing media

This product itself is not flammable.

4 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date2017/4/7
2024/3/15

Unsuitable extinguishing media

No data available

Specific hazards

No data available

Specific extinguishing methods

In the case of a fire in the periphery, the portable container is quickly moved to asafe place.

Special protective equipment for
firefighters

Wear suitable protective equipment (gloves, glasses and a mask) in fire-fighting.

SECTION 6

Accidental release measures

Personal precautions, protective
equipment, and emergency
proceduresProtection equipment (specified as those in which the properties of the productare suitable) worn during operation so that airborne droplets, etc., do not adhere
to the skin and dusts and gases are not absorbed.

Environmental precautions

The leakage may not directly flow into rivers or sewage.

Methods and material forcontainment and cleaning up

The leaked material is scooped up, or swept up and gathered to be recovered in apaper bag or a drum.
After recovery, a small amount of the residue is absorbed in sediment, sawdust,
etc.

Secondary disaster prevention
measures

No data available

SECTION 7

Handling and storage

Precautions for safe handlingTechnical measures

Take measures for equipment as described in “8. Exposure controls/personal
protection” and wear protective equipment.

Safety handling precautions

Handling work must be practiced in a room where there is a local or total
ventilation facility.

Avoidance of contact

Refer to “10. Stability and reactivity.”

Hygiene measures

Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.

Conditions for safe storage,
including any incompatibilities

SECTION 8

Safe storage conditions

Store locked up.

Safety packaging material

No data available

Exposure controls/personal protection
Ca5(PO4)3(OH)CeO2No data available

No data available

Permissible concentration
ＡＣＧＩＨ

5 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Appropriate engineering controls

Date of Issue
Revised Date

Use sealed devices, equipment, or a local exhaust ventilation as much as possible.

Individual protection measures,such as personal protective
equipment

SECTION 9

Respiratory protection

Dustproof mask

Hand protection

Protective gloves

Eye/face protection

Dust-proof glasses

Skin protection

Protective clothing

Physical and chemical properties

Appearance
Physical state

Solid

Form

GranularColour

White

Odour

None

Ca5(PO4)3(OH)CeO2Melting point/freezing point

1614℃

2480℃

Boiling point or initial boiling point
and boiling range

No data available

3730℃

Flammability

No data available

No data available

Upper/lower flammability or
explosive limits

No data available

No data available

Flash point

No data available

No data available

Auto-ignition temperature

No data available

No data available

Decomposition temperature

No data available

No data available

pH

No data available

No data available

Kinematic viscosity

No data available

No data available

Water

Insoluble

Insoluble

Other solvents

Soluble in acid

And insoluble in solvents

Partition coefficient: noctanol/water

No data available

No data available

Vapour pressure

No data available

No data available

Density and/or relative density

3.16

7.21

Solubility（Density）
Relative vapor density

2017/4/7
2024/3/15*1.09 as PHILICFINE HP-3 (bulk density in granular state)
No data available

No data available6 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date2017/4/7
2024/3/15

Particle characteristics

No data available

No data available

Other information

No data available

No data available

Ca5(PO4)3(OH)CeO2Reactivity

No data available

No data available

Chemical stability

Stable under normal handling and storage
conditions.

It is considered stable.

Possibility of hazardous reactions

No data available

Do not react in the storage conditions andnormal handling.
It will generate NOx gas in the reaction ofchlorine gas, and nitric acid reaction withhydrochloric acid.

Conditions to avoid

No data available

High-temperature and humidity

Incompatible materials

No data available

Carbon dioxide, acid

SECTION 10

Stability and reactivity

Hazardous decomposition products Hydrogen phosphide, phosphorus oxide

SECTION 11

Acid mist is generated upon dissolution of
the acid.

Toxicological information
Ca5(PO4)3(OH)CeO2Acute toxicity(oral)

No data available

Rat LD50 value:> 5000 mg / kg bw (IUCLID(2000))

Acute toxicity(dermal)

No data available

Based on the result that administration of2000 mg/kg bw to rats caused no mortality,and LD50 value was > 2000 mg/kg bw(IUCLID (2000)), the substance wasclassified as "Not classified".

Acute toxicity （Inhalation: Gases）

No data available

Solid (GHS definition)

Acute toxicity （Inhalation:
Vapours）

No data available

No data available

Acute toxicity （Inhalation: Dusts
and mists）

No data available

Based on the rat LC50 value of 5.05 mg/L
(OECD TG 403) (IUCLID (2000)), thesubstance was classified as "Not classified"in the JIS classification (corresponding toCategory 5 in the UN-GHS classification).
According to the description that the test
particles which was less than 3 micrometerin particle diameter were account for 85.4%(IUCLID (2000)), the criterion values for
dust/mist were adopted.

7 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date2017/4/7
2024/3/15

Skin corrosion/irritation

May irritate the skin.

In the rabbit test (OECD TG404), applicationof 0.5 g of test substance caused noirritation (IUCLID (2000)). In another rabbit
test, the primary skin irritation index value
was 0.0 and it was concluded that thesubstance was not irritating (IUCLID (2000)).
Based on the information, the substance wasclassified as "Not classified".

Serious eye damage/irritation

May irritate the eye.

Respiratory or skin sensitization

May irritate the Respiratory.

In the rabbit test (OECD TG405), instillationof 0.1 g of test substance to eye resulted in
non-irritating (IUCLID (2000)). In anotherrabbit test, slightly irritating was reported(IUCLID (2000)). Based on the information,
the substance was classified as "Notclassified".
In the maximization test using guinea pigs
(OECD TG406), no reaction of sensitization
was observed after elicitation, and concluded
as a non-sensitizer (IUCLID (2000)).
However, since it was the "List 2"
information source designated in the GHS
classification guidance for the Japanese
government, the substance was classified as"Classification not possible".

Germ cell mutagenicity

No data available

The substance was classified as"Classification not possible" due to thenegative results in the micronucleus test
(OECD TG474) using bone marrow cells ofmice orally administered (in vivo
mutagenicity test in somatic cells) (IUCLID(2000)). As relevant information, as for invitro study, negative results in the Ames
test were reported (Initial Environmental Risk
Assessment of Chemicals (Ministry of theEnvironment), vol. 8 (2010)).

Carcinogenicity

No data available

Reproductive toxicity

No data available

No data were available. As relevant
information, the US EPA reports that thedata of this substance are insufficient toevaluate the possibility of carcinogenicity inhumans under the carcinogenicity risk
assessment guidelines (IRIS (2009) Tox
Review).
No data available

Specific target organ toxicity(single No data available
exposure)

In the acute inhalation study in rats exposed
to dust for 4 hours at the range ofconcentrations from 4.12 to 5.98 mg/L
(OECD TG 433, GLP-compliant), labored
respiration and ruffled fur were noted in twoof ten animals, and the lungs of all animals
were incompletely collapsed with diffuse
whitish foci (IUCLID (2000)). Based on thesefindings observed in the concentration
corresponding nearly to the upper limit within
Category 2 of the guidance values, thesubstance was classified as Category 2(lung). In addition, in the acute oral toxicity
study in rats administered up to 5000 mg/kg
bw, no mortality was recorded, body weightgain was normal, and no abnormalities wereobserved at necropsy (IUCLID (2000)).

8 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date2017/4/7
2024/3/15

Specific target organ
toxicity(repeated exposure)

No data available

In the lungs of the workers exposed for many
years to the fumes of rare-earth elements
such as cerium, accumulation of rare-earth
elements was observed, and lung lesions
such as granuloma, emphysema, orinterstitial fibrosis and decrease of
pulmonary breathing capacity were reported(Initial Environment Risk Assessment ofChemicals (Ministry of Environment), vol. 8(2010)). Many reports were publisheddescribing long-term residue of rare earth
elements in lung and numerous cases ofworkers who developed adverse lung effects
associated with cerium oxide as follows. In
the case of the 58-year-old worker whocame to hospital complaining of dyspnea atleast 15 years after exposures to cerium
oxide polishing agents, slight pleural
thickening, and pulmonary obstruction werenoted. He was diagnosed by histopathologicalexamination as chronic pachypleuritis (Initial
Environment Risk Assessment of Chemicals(Ministry of Environment), vol. 8 (2010)). In
the case of 68-year-old man who was
engaged in the abrasive operation of the
optical lens for 35 years, rare earth
pneumoconiosis associated with cerium
oxide exposure was identified after 13 yearsof separation of work (PATTY, 5th (2001)).
On the other hand, in the 13-week repeatedinhalation study in rats exposed to dust,
enlargement and discoloration of diaphragmin approximately half of the animals, changesof bronchial lymph nodes in all animals were
found at 5 mg/㎥ or higher, and discolorationof the lungs in all animals at 51 mg/㎥ orhigher at necropsy. Histopathologically,
lymphoid hyperplasia and pigmentation in the
bronchial lymph nodes, and pigmentation in
the lung were noted at 5 mg/㎥ or higher inboth sexes, and alveolar epithelial
hyperplasia in the lungs and metaplasia andpigmentation in the larynx were noted at 51
mg/㎥ or higher in both sexes (Initial
Environment Risk Assessment of Chemicals(Ministry of Environment), vol. 8 (2010)).
These effects were observed at doses within
Category 1 of the guidance values. Based on
the findings for both humans andexperimental animals, the substance wasclassified as Category 1 (lung).

Aspiration hazard

No data available

No data available

Other information

No data available

SECTION 12

Ecological information
Ca5(PO4)3(OH)Toxicity

CeO2

9 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date2017/4/7
2024/3/15

Hazardous to the aquatic
environment Shortterm(acute)No data available

No data available

Hazardous to the aquatic
environment Longterm(chronic)

No data available

No data available

Persistence and degradablility

No data available

No data available

Bioaccumulative potential

No data available

No data available

Mobility in soil

No data available

No data available

Hazard to the ozone layer

No data available

This substance is not listed in Annexes tothe Montreal Protocol.

Other adverse effects

No data available

No data available

SECTION 13

Disposal considerations

Waste treatment methods

Process is contracted to industrial waste disposers who received approval of aprefectural governor.

Contaminated container andcontaminated packaging

The container is recycled after being cleaned, or is appropriately processed
according to the standards of related laws and regulations.
When disposing of empty containers, the contents should be completely removed.

SECTION 14

Transport information
Ca5(PO4)3(OH)CeO2UN number

Not applicableNot applicable

UN proper shipping nameNot applicableNot applicable

UN classification

Not applicableNot applicable

Transport hazard class

Not applicableNot applicable

Packing group

Not applicableNot applicable

Hazardous to the aquatic
environment

No data available

No data available

Maritime transport in bulk
according to IMO instruments

No data available

No data available

Japanese lows and regulations

No data available

No data available

Special precautions for users

No data available

Requires retention of yellow card whentransporting.
When transporting, protect from direct
sunlight and take on cargo without breakageof container, corrosion and leakage.
Do not transport with food and feedstuffs.
Do not stack heavy good thereupon.

International regulation

10 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

EH10
ＰＨＩＬＩＣＦＩＮＥ ＨＰ－３

SAFETY DATA SHEET
rev. 8.0

Special Provisions
SECTION 15-

Date of Issue
Revised Date2017/4/7
2024/3/15-

Regulatoly information（Japan）
Ca5(PO4)3(OH)CeO2

Occupational Safety and Health
Law

No data available

No data available

PRTR Law

No data available

There is it in the case of an application or an
application

Poisonous and Deleterious
Substances control Law

No data available

No data available

Labor Standards Act

No data available

No data available

Chemical substances control Law

No data available

No data available

Fire fighting Law

No data available

No data available

Air Pollution Control Act

No data available

No data available

Water Pollution Prevention Act

No data available

No data available

Water Supply Act

No data available

No data available

Sewerage Act

No data available

No data available

Marine Pollution Prevention Law

No data available

No data available

Waste Management and Public
Cleansing Act

No data available

No data available

Note

Ensure this material in compliance with federal requirements and ensure
conformity to local regulations.

SECTION 16

Other information

The Safety Data Sheet (SDS) has been prepared based on currently available materials, information and data, and may berevised based on new information. Further, the important points in the SDS are made for the purpose of normal handling.
When handling the user product in a specialized manner, take the appropriate safety measures for the application or method.
Further, Canon Optron Inc. has paid sufficient attention to the described contents of the SDS, but does not guarantee theaccuracy of its contents.
The SDS prepared by our company includes all findings from our investigation for reference. Not applicable to all items listed.

Literature Reference[WEB site]
National Institute of Technology and Evaluation Homepage
Japan Advanced Information Center of Safety and Health Homepage
Ministry of Health, Labour and Welfare Homepage[Regulatory review Tools]
ezCRIC+ (Japan Chemical Database Ltd)