YEAST EXTRACT (GLUTATHIONE) BENEFITS
Yeast extract, particularly rich in glutathione, is a highly valued ingredient in various sectors
including food, health, and cosmetics due to its substantial health benefits. Glutathione within
yeast extract is a powerful antioxidant, which plays a crucial role in cellular defense
mechanisms.
1. Overview of Yeast Extract and Glutathione
Yeast Extract Definition: Yeast extract is a product derived from the cell contents of yeast using
a process that removes the cell walls. It is known for its rich flavor and is used as a food additivefor its taste-enhancing properties.
Glutathione Composition : Glutathione is a tripeptide composed of glutamine, cysteine, andglycine. It is one of the most potent antioxidants, found naturally in some foods and synthesized
by the body.
2. Antioxidant Properties
Cellular Protection: Glutathione in yeast extract helps protect cells from damage caused by freeradicals, which are linked to aging and various diseases.
Enhancement of Antioxidant Networks: It works in synergy with other antioxidants like vitamin Cand E, regenerating them after they have been oxidized.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851219/
Conclusion of the above research report:
Thiol redox regulation plays a long-recognized role in the response of cells to oxidative stressconditions. Our current data emphasize the importance of compartmentalized redox regulation
when cells are subjected to oxidative stress conditions. Whilst cytosolic glutathione represents
the first major pool of thiols which would be a target of oxidation in response to exposure to an
exogenous oxidant, it is the mitochondrial glutathione pool which is crucial for oxidant tolerance.
3. Detoxification
Elimination of Toxins: Glutathione plays a critical role in detoxifying harmful substances in theliver, which are then excreted through bile.
Protection Against Environmental Pollutants: Regular intake of glutathione-enriched yeast
extract can help defend against the adverse effects of environmental toxins and pollutants.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1569131/

Conclusion of the above research report:
Glutathione (GSH) is crucial for detoxifying harmful substances in the body by reacting withcertain electrophiles, though it is less effective with very weak or strong ones. Specializedenzymes called GSH transferases assist GSH in this process, each tailored to handle different
toxins. While some harmful compounds, especially carcinogens, do not react well with these
enzymes, GSH still plays a major role in eliminating toxins, often through bile. Additionally, GSH
transferases are involved in transporting bilirubin, distributing heme, and preventing lipid
peroxidation, making them essential for overall detoxification and protection.
4. Immune System SupportEnhancing Immune Function: Glutathione is crucial for the optimal function of T-lymphocytes
and other immune cells, helping the body fight off infections and diseases.
Reduction of Oxidative Stress: By reducing oxidative stress, glutathione can prevent thesuppression of the immune system that might be caused by chronic oxidative stress.
https://pubmed.ncbi.nlm.nih.gov/11115795/
Conclusion of the above research report:
The immune system requires a carefully balanced level of glutathione to function optimally.
Moderate changes in glutathione levels can significantly impact lymphocyte functions. Highglutathione levels favor some functions, such as DNA synthesis, while low levels favor others,
like certain signaling pathways. Healthy individuals typically have optimal glutathione levels, andsupplementing with glutathione or cysteine doesn't enhance immune function in these
individuals. However, in diseases associated with glutathione deficiency, such as HIV, cysteine
supplementation can significantly improve immune functions. This includes restoring naturalkiller cell activity.
5. Anti-Aging and Skin Health:Skin Health: Glutathione in yeast extract can contribute to healthier skin by reducing the impactof free radicals that accelerate aging signs.
Improving Skin Elasticity and Reducing Wrinkles : Its antioxidant properties help maintain theskin's elasticity and reduce wrinkles. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413479/
Conclusion of the above research report:
The study demonstrates that oral administration of 250 mg/day of glutathione (both GSH andGSSG) significantly improves skin properties, such as reducing pigmentation and enhancing
elasticity and wrinkles, especially in middle-aged women. Glutathione is effectively absorbedorally, though its stability differs between forms. The research also highlights glutathione's dualrole in detoxification and anti-aging, with no major adverse effects reported.

6. Potential Role in Disease Prevention- Chronic Disease: High levels of glutathione have been associated with reduced risk of chronic
diseases such as cancer, heart disease, and neurodegenerative disorders.
- Support in Metabolic Health: Glutathione may help improve insulin sensitivity and reduce thecomplications of diabetes. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8389000/
Conclusion of the above research report:
Glutathione (GSH) is vital in maintaining the balance between oxidant production andantioxidant defense, impacting cellular functions such as detoxification, cell proliferation,apoptosis, and gene expression. Imbalances in GSH are linked to various diseases, including
cancer, diabetes, cystic fibrosis, neurodegenerative disorders like Parkinson's and Alzheimer's,and COVID-19. GSH deficiency contributes to oxidative stress, aging, and cardiovasculardiseases (CVD). Studies indicate that lower plasma GSH levels increase CVD risk, and dietary
habits, such as adhering to the Mediterranean diet, can positively influence GSH levels andendothelial function, thereby reducing CVD risk. Understanding GSH's role in these processes
underscores its importance in health and disease management.
Conclusion:
Yeast extract enriched with glutathione presents numerous health benefits, primarily related toits powerful antioxidant properties that contribute to detoxification, immune support, andpotentially anti-aging and disease prevention. Its application in food and supplements continues
to grow as research uncovers more of its health-promoting potential. This report outlines thegeneral benefits as observed in scientific studies.