1 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

SECTION 1

2013/10/16
2024/3/15

Chemicals and company identification

Product nameＴｉＯ２

Product code

ET04

Company nameCANON OPTRON INC.

Address

1744-1, Kanakubo, Yuki-shi, Ibaraki-ken, 307-0015 Japan

Section nameSales Department

Telephone number+81-296-21-3700

Fax number+81-296-21-3770

Emergency telephone tumber+81-296-21-3700

Use

Vacuum deposition material

SECTION 2

Date of Issue
Revised Date

Hazards identification

GHS Classification （A classification by JIS Z 7252 "classification methods such as chemical substances based on GHS"）
Physical hazards

Health hazards

Explosives

Classification not possible

Flammable gases

Not applicable

Aerosols

Not applicable

Oxidizing gases

Not applicableGas under pressure

Not applicable

Flammable liquids

Not applicable

Flammable solids

Classification not possible

Self-reactive substances and mixtures

Classification not possible

Pyrophoric liquids

Not applicable

Pyrophoric solids

Classification not possible

Self-heating substances and mixtures

Classification not possible

Substances and mixtures which,incontact with water,emit flammablegases

Classification not possible

Oxidizing liquids

Not applicable

Oxidizing solids

Classification not possible

Organic peroxides

Classification not possible

Corrosive to metals

Classification not possible

Desensitize explosives

Classification not possible

Acute toxicity(oral)

Not classified

Acute toxicity(dermal)

Not classified

Acute toxicity (Inhalation: Gases)

Not applicable

Acute toxicity (Inhalation: Vapors)

Classification not possible

2 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date

Acute toxicity (Inhalation: Dusts andmists)

Not classified

Skin corrosion/irritation

Not classified

Serious eye damage/eye irritation

Classification not possible

Respiratory sensitization

Classification not possible

Skin sensitization

Not classified

Germ cell mutagenicity

Classification not possible

Carcinogenicity

Category 2

Reproductive toxicity

Classification not possible

2013/10/16
2024/3/15

Reproductive toxicity, effects on or via Classification not possible
lactation

Environmental hazards

Specific target organ toxicity(single
exposure)Classification not possible

Specific target organ toxicity(repeatedexposure)

Category 1

Aspiration hazard

Classification not possible

Hazardous to the aquatic environment
Short-term(acute)

Not classified

Hazardous to the aquatic environmentLong-term(chronic)

Not classified

Hazardous to the ozone layer

Classification not possible

Label elements
hazard Pictograms

Health Hazard
Health Hazard

Signal word

DangerDangerous goods hazard
information

Suspected of causing cancer.
Causes damage to organs through prolonged or repeated exposure Respiratoryorgans.

Precautionary statements【Safety measures】

Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Do not breathe dust/fume/gas/mist/vapours/spray.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
Wear Protective glovess/protective clothing/eye protection/face protection.

3 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

SECTION 3

Date of Issue
Revised Date【First-aid measures】

If exposed or concerned：Get medical advice/attention.
Get medical advice/attention if you feel unwell.

【Storage】

Store locked up.

【Disposal】

Dispose of contents/container in accordance with national regulations.

【Other hazards】-

Composition/information on ingredients

Substance/Mixture

MixtureChemical nameTitanium oxide

Chemical formula

TiO2

Concentration or concentration
range

99.9<

CAS No.

13463-67-7

TSCA Inventry

Titanium oxide (TiO2)

EINECS number

236-675-5

Radioactive information

Radioactive substances are not used as the material. Therefore, there is no
reason that ionizing radiation would be generated.

SECTION 4

First aid measures

Inhalation

Remove person to fresh air and keep comfortable for breathing.
Get medical advice/attention if you feel unwell.

Skin contact

Take off immediately all contaminated clothing. Rinse affected areas withwater/shower.
IF ON SKIN：Wash with plenty of soap and water.
If skin irritation or rash occurs: ：Get medical advice/attention.

Eye contact

Rinse cautiously with water for several minutes.Remove contact lenses, if
present and easy to do. Continue rising.
If eye irritation persists：Get medical advice/attention.

Ingestion

Rinse mouth.
Get medical advice/attention.

Most important symptoms andeffects, both acute and delayed

No data available

Protection of first aiders

Rescuers, wear suitable protective equipment as the situation demands.

Special precautions for physicians

No data available

SECTION 5

2013/10/16
2024/3/15

Firefighting measures

Suitable extinguishing media

It use a water mist, dry chemicals, fire foam, carbon dioxide depending on theneighboring situation and the situation of the fire.

Unsuitable extinguishing media

Because a fire might spread through the outskirts, It avoid direct stick irrigation.

4 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date

2013/10/16
2024/3/15

Specific hazards

In the case of fire, highly toxic degradation products may be generated.

Specific extinguishing methods

It performs the fire fighting from windward.
Restrict access to the area around the fire location to persons other than those
involved with the fire.
If it is not dangerous to do so, move the container out of the fire area.

Special protective equipment for
firefighters

On the occasion of fire extinguishing work, it wears appropriate personal
protective equipment and rescue suit.

SECTION 6

Accidental release measures

Personal precautions, protective
equipment, and emergency
procedures

It prohibits the entrance except the person concerned.
The worker wears appropriate personal protective equipment (in item of"8.revelation prevention and protection measures" reference) and avoids eyes,
contact and inhalation to skin.

Environmental precautions

It avoids an outflow to the environmental average of the product to havepossibilities to influence neighboring environment.

Methods and material forcontainment and cleaning up

It collects it in sky containers as if sweeping the scattered thing, and gathering
you, or being able to absorb it with a vacuum sweeper, and from scattering not
pitching a camp.
The prohibition of handling and eating and drinking in neighboring of the storagearea.
It prevents the inflow to a drainage, a sewer, a basement or the closedown place.

Secondary disaster prevention
measures

No data available

SECTION 7

Handling and storage

Precautions for safe handlingTechnical measures

Take measures for equipment as described in “8. Exposure controls/personal
protection” and wear protective equipment.

Safety handling precautions

It prevents you from producing dust.

Avoidance of contact

Refer to “10. Stability and reactivity.”

Hygiene measures

Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.

Conditions for safe storage,
including any incompatibilities

SECTION 8

Safe storage conditions

It avoids direct rays of the sun and keeps it in the cool and dark space.
Store locked up.

Safety packaging material

No data available

Exposure controls/personal protection
TiO2

Permissible concentration

5 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

ＡＣＧＩＨ

Appropriate engineering controls

Date of Issue
Revised Date

TLV-TWA: 10 mg/㎥ (titanium dioxide)(2016 version)
In the work shop which dust produces, It use a device, an apparatus sealed up by
all means or a local ventilator.

Individual protection measures,such as personal protective
equipment

SECTION 9

2013/10/16
2024/3/15

Respiratory protection

Dustproof mask

Hand protection

Protective gloves

Eye/face protection

Dust-proof glasses

Skin protection

Protective clothing

Physical and chemical properties

Appearance
Physical state

Solid

Form

Pellets, granules

ColourBlue black or white

Odour

None

TiO2
Melting point/freezing point

1855℃

Boiling point or initial boiling point
and boiling range

2500～3000℃

Flammability

No data available

Upper/lower flammability or
explosive limits

No data available

Flash point

No data available

Auto-ignition temperature

Noninflammability (HSDB (2016))

Decomposition temperature

1,860℃ (GESTIS (2016))

pH

SUSPENSION IN WATER (1 IN 10) IS NEUTRAL TO LITMUS (HSDB (2016))

Kinematic viscosity

No data available

Solubility
Water

Insoluble

Other solvents

No data available

Partition coefficient: noctanol/water

No data available

Vapour pressure

No data available

Density and/or relative density

4.23

6 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0（Density）

2013/10/16
2024/3/15※ (bulk density of the granular product) from 2.10 to 2.45 as TiO2

Relative vapor density

No data available

Particle characteristics

No data available

Other information

No data available

SECTION 10

Date of Issue
Revised Date

Stability and reactivity
TiO2

Reactivity

It is stable under the normal handling condition.

Chemical stability

It is stable under the normal handling condition.

Possibility of hazardous reactions

Dangerous adverse reaction is not caused under the normal handling condition.

Conditions to avoid

It avoid direct rays of the sun and keep it in the cool and dark space.

Incompatible materials

Oxidizer, reducer

Hazardous decomposition products In the case of fires, a toxic decomposition product may occur.

SECTION 11

Toxicological information
TiO2

Acute toxicity(oral)

For a rat LD50 price,> 2,000 mg/kg,> 5,000 mg/kg (SIDS (2015)) ,> 10,000 mg/kg(HSDB (Access on May 2016), Ministry of the Environment risk evaluation Vol. 8(2010)) ,> 12,000 mg/kg,> 20,000 mg/kg (Ministry of the Environment risk
evaluation Vol. 8 (2010)) There is a report.

Acute toxicity(dermal)

For an LD50 price of the hamsters,> 10,000 mg/kg (HSDB (Access on May 2016),
Ministry of the Environment risk evaluation Vol. 8 (2010)) There is a report.

Acute toxicity （Inhalation: Gases）

Solid (GHS definition)

Acute toxicity （Inhalation:
Vapours）

Solid (GHS definition)

Acute toxicity （Inhalation: Dusts
and mists）

Based on a report of an LC50 value for rats of > 5.09 mg/L (SIDS (2015)), it wasclassified as "Not classified."

Skin corrosion/irritation

From descriptions (SIDS (2015)) of slight or no irritation in skin irritation tests
using rabbits, it was classified as "Not classified" (Category 3 in UN GHS
classification).

Serious eye damage/irritation

There is a report that in an eye irritation test (OECD TG 405) using rabbits, mild
conjunctival redness was observed in 2 out of 3 animals 24 hours after theapplication, but disappeared within 48 hours, and there is a report that slightirritation was observed 24 hours after the application, but no irritation wasobserved after 48 and 72 hours (SIDS (2015)). The irritation observed in thesetests may be thought to be due to physical stimulation, however, since theparticle shape could not be confirmed, it was classified as "Classification notpossible."7 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date

2013/10/16
2024/3/15

Respiratory or skin sensitization

Both a skin sensitization test using the guinea pigs (Buehler method, OECD TG
406) and a skin sensitization test using mice (LLNA method, OECD TG 429) were
negative, and it was judged that this substance doesn't have skin sensitizing
potential (SIDS (2015)). Therefore, it was classified as "Not classified."Germ cell mutagenicity

As for in vivo, it was reported that micronucleus tests using peripheral
erythrocytes or bone marrow cells of mice were negative, an hprt gene mutation
assay using alveolar cells of rats was positive, a chromosomal aberration test
using mouse bone marrow cells and a DNA damage test in rat lungs were
negative (SIDS (2015), National Institute of Advanced Industrial Science andTechnology (2011), DFGOT (2014), Environmental Risk Assessment for Chemical
Substances Vol. 8 (Ministry of the Environment, 2010), IARC 93 (2010)). As for invitro, negative results were reported in all of bacterial reverse mutation tests,
micronucleus tests, chromosome aberration tests, and mouse lymphoma assays
using cultured mammalian cells (SIDS (2015), OEL Documentations (Japan
Society For Occupational Health (JSOH), 2013), National Institute of Advanced
Industrial Science and Technology (2011), IARC 93 (2010), Environmental Risk
Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010),
DFGOT (2014)). In addition, it is evaluated in SIDS (2015) that it is not possible
to conclude on the genotoxicity of this substance because positive in vivo
findings are not by standard tests. From the above, it was classified as"Classification not possible."

Carcinogenicity

In a large-scale cohort study in Europe, the mild increase of the risk of the lungcancer was suggested by the occupation revelation to this material, but it wassaid to this material revelation and association with the carcinogenesis that the
carcinogenic evidence in the Homo sapiens was restrictive in others which adose-response relationship was not seen in in revelation group, a cohort study in
the North America and the case-control study without being shown (IARC 93(2010)) . Increase of the frequency of adenoma of the lungs and the squamouscancer was seen in a rat in one inhalational examination that came to light in theexperimental animals in high density group (250 mg/㎥) for two years (IARC 93(2010), SIDS (2015)) . In addition, increase (32/100 vs. control group 1/271) of
the outbreak frequency of the lung tumor (benign squamous epithelium tumor,
squamous cancer, adenoma, adenocarcinoma) was seen in the revelation group,
but oncogenic increase was not seen even in the examination that inhaled super
finer particles (P25) of this material to a rat for two years, and came to light inthe murine examination (IARC 93 (2010)) . In addition, it was admitted thefrequency increase of the benign and malignant lung tumor in the intratracheal
examination that It injected to lat with titanium oxide. On the other hand, theincrease of tumor was not seen in a rat, a mouse in oral, subcutis, neither
examination that It gave intraperitoneally (IARC 93 (2010)) . It classified the IARC
in group 2B than the above saying that there was carcinogenic enough evidence
in the experimental animals (IARC 93 (2010)) . In addition, Nihon Sangyo hygiene
society classifies it in second group B as a temporary classification (advice(2015) of the acceptable concentration) .

Reproductive toxicity

In a reproduction/developmental toxicity screening test (OECD TG 421) using
rats, no adverse effects on fertility of parental animals, survival and development
up to 4 days after delivery of offspring were observed even up to at a dose of
1,000 mg/kg/day administered by gavage (SIDS (2015)). However, because thistest is a screening test, it was not possible to classify this substance as "Notclassified" only from this result, and there is no other data available forclassification. Therefore, the classification was not possible due to lack of data.

Specific target organ toxicity(single No data available
exposure)8 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date

2013/10/16
2024/3/15

Specific target organ
toxicity(repeated exposure)

There is no information on humans.
As for experimental animals, in a 2-year inhalation toxicity test using rats,
increases in leukocyte and neutrophil counts, and increase in pneumonia,
tracheitis, and rhinitis with squamous metaplasia in the anterior nasal cavity wereobserved at 10 mg/㎥ which is in the range of Category 1, and in a 24-monthinhalation toxicity study using rats, lung fibrosis, minor changes in cytologic
pattern in bronchoalveolar lavage fluid (BALF), a slight increase inpolymorphonuclear leukocyte count, increase in macrophage and hyperplasia ofthe lung-associated lymph nodes were observed at 5 mg/㎥ (SIDS (2015)).
Besides, as for oral route, no effects were observed even at doses
corresponding to "Not classified" in 13-week or 103-week repeated dose toxicity
tests using rats or mice dosed by feeding (Environmental Risk Assessment for
Chemical Substances Vol. 8 (Ministry of the Environment, 2010)).
Therefore, it was classified in Category 1 (respiratory organs).

Aspiration hazard

No data available

Other information

No data available

SECTION 12

Ecological information
TiO2

Toxicity
Hazardous to the aquatic
environment Shortterm(acute)

From 72-hour EL50 (growth rate) > 100 mg/L for algae (Pseudokirchneriellasubcapitata), 48-hour EL50 > 100 mg/L for crustacea (Daphnia magna), and 96hour LL50 > 100 mg/L for fish (Oryzias latipes) (all SIDS, 2015), it was classified
as "Not classified."

Hazardous to the aquatic
environment Longterm(chronic)

Reliable chronic toxicity data were not obtained. It is poorly water-soluble(insoluble in water, ICSC, 2002), and classified as "Not classified" for acutetoxicity, but due to the unknown environmental behavior of the inorganic
compound, it was classified in Category 4.

Persistence and degradablility

No data available

Bioaccumulative potential

No data available

Mobility in soil

No data available

Hazard to the ozone layer

No data available

Other adverse effects

No data available

SECTION 13

Disposal considerations

Waste treatment methods

Process is contracted to industrial waste disposers who received approval of aprefectural governor.

Contaminated container andcontaminated packaging

The container is recycled after being cleaned, or is appropriately processed
according to the standards of related laws and regulations.
When disposing of empty containers, the contents should be completely removed.

9 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

SECTION 14

Date of Issue
Revised Date

Transport information
TiO2

International regulation
UN number

Not applicable

UN proper shipping nameNot applicable

UN classification

Not applicable

Transport hazard class

Not applicable

Packing group

Not applicable

Hazardous to the aquatic
environment

No data available

Maritime transport in bulk
according to IMO instruments

No data available

Japanese lows and regulations

Land regulation information Not applicable
Maritime regulatory information non-hazardous materials
Aviation regulatory information non-hazardous materials

Special precautions for users

When transporting, protect from direct sunlight and take on cargo without
breakage of container, corrosion and leakage.
Do not stack heavy good thereupon.

Special Provisions-

SECTION 15

Regulatoly information（Japan）
TiO2

Occupational Safety and Health
Law

There is it in the case of an application or an application

PRTR Law

Not applicable

Poisonous and Deleterious
Substances control Law

Not applicable

Labor Standards Act

There is it in the case of an application or an application

Chemical substances control Law

Not applicable

Fire fighting Law

Not applicable

Air Pollution Control Act

Not applicable

Water Pollution Prevention Act

Not applicable

Water Supply Act

Not applicable

Sewerage Act

Not applicable

Marine Pollution Prevention Law

There is it in the case of an application or an application

2013/10/16
2024/3/15

10 / 10 Page
CANON OPTRON INC.
SDS Number：
Product Name：

ET04
ＴｉＯ２

SAFETY DATA SHEET
rev. 8.0

Date of Issue
Revised Date

Waste Management and Public
Cleansing Act

Not applicable

Note

Ensure this material in compliance with federal requirements and ensure
conformity to local regulations.

SECTION 16

2013/10/16
2024/3/15

Other information

The Safety Data Sheet (SDS) has been prepared based on currently available materials, information and data, and may berevised based on new information. Further, the important points in the SDS are made for the purpose of normal handling.
When handling the user product in a specialized manner, take the appropriate safety measures for the application or method.
Further, Canon Optron Inc. has paid sufficient attention to the described contents of the SDS, but does not guarantee theaccuracy of its contents.
The SDS prepared by our company includes all findings from our investigation for reference. Not applicable to all items listed.

Literature Reference[WEB site]
National Institute of Technology and Evaluation Homepage
Japan Advanced Information Center of Safety and Health Homepage
Ministry of Health, Labour and Welfare Homepage[Regulatory review Tools]
ezCRIC+ (Japan Chemical Database Ltd)