Appemdix 1:
DPR31 Table 11, Table12, and Table13 記載のデータに基づく一致率、感度、ならびに特異度について
DRP31 Table 11, Table12, and Table13 に掲載データから、SHE CTA のデータが記載されている化合物（有機化合物および無機化合物）を抽出し、まとめ直した結果を記載する．
有機化合物

Carcinogenicity
Carcinogen
SHE CTA

Non carcinogen

Positve

10716123

Negative

20476712763190

Concordance

81.1

Sencitivity

84.3

Specificity

74.6

無機化合物

Carcinogenicity

SHE CTA

Carcinogen

Non-carcinogen

Positve

47552

Negative

12348

755

Concordance

89.1

Sencitivity

97.9

Specificity

28.6

有機化合物+無機化合物

Carcinogenicity
Carcinogennon carcinogen

SHEPositve

154

21175

CTA

Negative

21497017570245

Concordance

82.9

Sencitivity

88.0

Specificity

70.0

20170209 資料

Appendix 1-1
SHE CTAの結果とげっ歯類がん原物質ならびに非がん原物質との相関について
げっ歯類がん原物質での結果(有機化合物)

物 質 名

pH別結果
pH6.7

Acetamide
2AAF
Acrylamide
Acrylonitrile++ActinomycinD
Aflatoxin B1
2-Amino-5-azotoluene
4-Amino-1,1’-biphenyl (4-Aminobiphenyl)
2-Aminoanthracenep-Aminoazobenzene
Amitrole [3-Aminotriazole]
Anilineo-Anisidine
Anthraquinone

5-Azacytidine

BenzeneBenzidine+

Benzoyl peroxide
Benzyl chloride
HC Blue 1
5-Bromo-2’-deoxyuridine
Butylated hydroxytoluene (BHT)

Chloral hydrate
Chlordane Analytical+++-+++++++++++Catechol

陰性+++++++++++-Benz(a)anthracene

Butylbenzylphthalate++++++++++++++

Aroclor 1260

Benzo(a)pyrenepH≧7.0 陽性-

Aroclor 1254

BenomylSHE CTAの結果+++++++++++++++

物 質 名

pH別結果
pH6.7

p-Chloroaniline
Chlorothalonil
Chrysene Benzophenanthrene
Cinnamyl anthranilate
Clofibrate++

Cyclophosphamide
Decabromo diphenyloxide2,4-Diaminotoluene+

Dibenz(a,h)anthracene
Dichlorodiphenyl trichloroethane(DDT)
2,6-Dichloro-p-phenylenediamine
Dichlorvos
Diepoxybutane, 1,2 :3,4Diethanolaminedi (2-Ethylhexyl) phthalate(DEHP)
Diethylstilbestrol (DES)
N,N’-Diethylthiourea+++

N,N’-Dimethyl-4-aminoazobenzene [4-Dimethylamino-azobenzene]
7,12-Dimethyl benzanthracene
1,2-Dimethylhydrazine
2,4-Dinitrotoluene
2,6-Dinitrotoluene++

Epichlorhydrin
Estradiol
Ethinylestradioll-Ethionine
Ethyl benzene+

Furfuryl alcohol
Furylfuramide (AF-2)

陰性++++++-++++++++++-++++

Ethyl methanesulfonate
Formaldehyde+++++++1,2-Epoxybutane

Ethyl alcohol [Ethanol]pH≧7.0 陽性+Diphenylhydantoin

SHE CTAの結果+-++++++++++++++++++++++-++

物 質 名Genistein

pH別結果
pH6.7

Hydroquinone
N-Hydroxy-2-acetylaminofluorene-Melphalan [Sarkolysin ][Phenyl alanine mustard]
Metaproterenol hemisulfate
Methapyrilene HCl+3-Methoxy-4-aminoazobenzene
Methyl eugenol
Methyl methane sulfonate (MMS)
Methylazoxymethanol acetate
3-Methylcholanthrene (MCA)+

Methylclofenapate
4,4’-Methylene bis-(N,N’-dimethylaniline)[Bis(pdimethylamino)diphenylmethane
Mezerein
Mitomycin CMonuron
2-Naphthylamine
Nitrilotriacetic Acid+-N-(4-(5-Nitro-furanyl)-2-thiazolyl)formamide
2-Nitro-p-phenylenediamine [2-Nitro-1,4-phenylenediamine]
5-Nitro-o-toluidine [2-Amino-4-nitrotoluene]
2-Nitropropane
4-Nitroquinoline-1-oxide [4-Nitroquinoline-N-oxide]
N-Nitroso-N-ethylaniline
N-Nitroso-N-ethylurea[N-Ethyl-N-nitrosourea (ENU)] [1-Ethyl-1-nitrosoruea]
N-Nitroso-N-methylnitroguanidine[N-Methyl-N’-nitro-Nnitrosoguanidinen(MNNG)]
N-Nitrosodiethylamine [Diethyl nitrosamine]+++++++++++-+++

Methyl iodide

Methylcarbamate (Methyl urethane)+-

Hexamethyl phosphoramide

陰性+

Hexachloro-1,3-butadiened-LimonenepH≧7.0 陽性-Glycidaldehyde
Griseofulvin

SHE CTAの結果+++++++++++++++++++++++++++++++++++++++物 質 名pH別結果
pH6.7

Okadaic acid4,4’-Oxydianiline
Oxymetholone
Phenacetin
Phenobarbital sodium PhenobarbitalpH≧7.0 陽性+++

N-Nitrosodiphenylamine [Diphenyl nitrosamine]++

Phenolpthalein
Phorbol 12,13-didecanoate (PDD)+++++

Procarbazine HCl
β-Propionolactone+

Propylene oxide+

1,2-Propyleneimine （Propyleneimine）+

Pyridine
Reserpine
p-Rosaniline (CI Basic Red 9) [Magenta]
SafroleTestosterone
12-O- Tetradecanoyl phobol-13-acetate (TPA)
Tetrahydrofuran+-Thiourea
o-Toluidine++++++

2,4,6-Trichlorophenol
Tris(2-ethylhexyl)phosphate (TEHP)
Urethane [Ethyl carbamate]
Wyeth-14,643+++++++++++++++-+o-Toluidine HCl++++-+++

Thioacetamide

陰性-+

Polybrominated biphenyls

SHE CTAの結果+++++-++++
107

20

げっ歯類非がん原物質での結果 (有機化合物)
物 質 名

pH別結果
pH6.7

Acetone4-Acetylaminofluorene-

SHE CTAの結果

pH≧7.0 陽性-

陰性-

物 質 名Acid red 14 (IC)

pH別結果
pH6.7

Anilazine
p-Anisidine
Anthracenel-Ascorbic acid+-Benzoin
HC Blue 2-n-Butyl acrylate
2-tert-Butyl-1,4-hydroquinone
Caprolactam-

Chloramphenicol
o-Chloroaniline
Colcemid (IC)+Dexamethasone
2,6-Diaminotoluene
Diazepam-Geranyl acetate
8-Hydroxyquinoline
Isobutyraldehyde

6-Mercaptopurine
Methotrexate+++-++-++-+

Lithocholic acidd-Mannitol++--Dimethylformamide
Eugenol--+-2,4-Dichlorophenoxyacetic acid

EDTA, trisodium salt trihydrate--

2,4-Dichlorophenol
2,4-Dimethoxyaniline HCl+-Caffeine

陰性--Benzo(e)pyrene
Bisphenol ApH≧7.0 陽性-

Acrylic AcidAmpicillin

SHE CTAの結果-+-

物 質 名Methoxychlor
1-Naphthylamine

pH別結果
pH6.7+-

Naphthyl isothiocyanate
4-Nitro-o-phenylenediamine（4-Nitro-1,2-benzenediamine）-

6-Nitrobenzo[a]pyrene
3-Nitropropionic acid
Pentoxifylline-PyreneHC Red 3
Resorcinol
Rotenone++Succinic anhydride

Thiabendazole

Vincristine sulfate (IC)FD and C Yellow n°6++++-+-+--

2,4,5-Trichlorophenoxyacetic acid
Triphenyltin hydroxide++-Tetracycline hydrochloride
Tetraethylthiuramdisulfide (Disulfiram)--Sorbic acidSulfisoxazole+陰性+-Saccharin (acid form)
Sodium xylenesulfonate+++PhenolPhthalic anhydridepH≧7.0 陽性-Phenanthrene
p-Phenylenediamine 2HCl(4-Aminoaniline dihydrochloride)

SHE CTAの結果+-+
1647

Appendix I-2
SHE CTAの結果とげっ歯類がん原物質ならびに非がん原物質との相関について
げっ歯類がん原物質での結果(無機化合物)

物 質 名pHの条件
pH6.7 pH≧7.0Amosite
Anthophyllite
Barium chromate
Basic lead silicochromate
Beryllium sulfate
Beryllium sulfate tetrahydrate
BiotiteCadmium acetate
Cadmium chloride+Calcium chromate
Chromium trioxide
Chrysotile+cis-Platinium diammine dichloride
Cobalt sulfate heptahydrate
Cristobalite
Glass fibre 100

SHE CTAの結果
陽性++++++++++++++++++++++++++++++++++++++++++++++++++++++

Glass fibre 110
Hydrogen peroxide
Lead acetate
Lead chromate
Lead molybdenum chromates
Lead sulphate chromates
Magnetite
Nemalite Brucite
Nickel (metallic)
Nickel chloride
Nickel monoxide
Nickel subsulfide++陰性

物 質 名pHの条件
pH6.7 pH≧7.0+

Nickel sulfate
Nickel sulfate heptahydrate+

Nickel sulfate hexahydrate
Nickel sulfide(crystalline)
Potassium chromate
Potassium dichromate
Quartz Min-U-Sil5 Silica Quartz
Refractory ceramic fibre-1,2,3,4Sodium arsenate
Sodium arsenite
Sodium chromate tetrahydrate
Sodium dichromate
Sodium nitrite
Strontium chromate
Titanium dioxide-Tremolite
Vanadium (V) pentoxide
Zinc chloride+++++++++++++++++++

Zinc chromate
Zinc oxide
Zinc potassium chromatesd

SHE CTAの結果
陽性

陰性++++++++++++++++++++471

げっ歯類非がん原物質での結果(無機化合物)

物質名

pHの条件
pH6.7 pH≧7.0

Chromium (III) chloride
Chromium (III) oxide
Chromium (metallic)
Diatomaceous earths
Ferric oxide
Sodium fluoride-++++

SHE CTAの結果
陽性

陰性++++

物 質 名Titanocene dichloride

pHの条件
pH6.7 pH≧7.0+SHE CTAの結果
陽性

陰性+52

Appendix II
SHE CTAとIARCクラス分類によるヒトがん原物質との相関について解析結果
有機化合物（げっ歯類がん原物質）
化学物質名

ヒトがん原物質IARC分類グループ

SHECTA結果

1陽性

2A

1 Acetamide

2B○

3 Acrylamide○

4 Acrylonitrile○

5 ActinomycinD
6 Aflatoxin B1○○

7 2-Amino-5-azotoluene
8 4-Amino-1,1’-biphenyl (4-Aminobiphenyl)

3○○10 p-Aminoazobenzene○

11 Amitrole [3-Aminotriazole]○

12 Aniline○

13 o-Anisidine○

17 5-Azacytidine○

19 Benz(a)anthracene○

20 Benzene○

21 Benzidine○

22 Benzo(a)pyrene○

24 Benzyl chloride○

25 HC Blue 1○

27 Butylated hydroxytoluene (BHT)○

28 Butylbenzylphthalate○

29 Catechol○

30 Chloral hydrate○

31 Chlordane Analytical○

32 p-Chloroaniline○

33 Chlorothalonil○

34 Chrysene Benzophenanthrene○

35 Cinnamyl anthranilate○

36 Clofibrate○

37 Cyclophosphamide○

39 2,4-Diaminotoluene
40 Dibenz(a,h)anthracene

○
○

4陰性

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化学物質名

ヒトがん原物質IARC分類グループ

SHECTA結果

1陽性

2A

41 Dichlorodiphenyl trichloroethane(DDT)

2B

3

○

43 Dichlorvos○

44 Diepoxybutane, 1,2 :3,4○

45 Diethanolamine○

46 di (2-Ethylhexyl) phthalate(DEHP)○○

48 N,N’-Diethylthiourea○

N,N’-Dimethyl-4-aminoazobenzene [4-49 Dimethylamino-azobenzene]

○
○
○
○
○
○
○

○

52 2,4-Dinitrotoluene○

53 2,6-Dinitrotoluene○

54 Diphenylhydantoin○

55 Epichlorhydrin○

56 1,2-Epoxybutane○

57 Estradiol○

58 Ethinylestradiol○

60 Ethyl alcohol [Ethanol]○○○

61 Ethyl benzene○

62 Ethyl methanesulfonate○

63 Formaldehyde

○
○
○
○
○

○

65 Furylfuramide (AF-2)○

67 Glycidaldehyde○

68 Griseofulvin○

69 Hexachloro-1,3-butadiene○○

70 Hexamethyl phosphoramide○

71 Hydroquinone○

73 d-Limonene
Melphalan [Sarkolysin ][Phenyl alanine
74
mustard]○

80 Methyl methane sulfonate (MMS)
81 Methylazoxymethanol acetate82 Methylcarbamate (Methyl urethane)
4,4’-Methylene bis-(N,N’-dimethylaniline)85[Bis(pdimethylamino)diphenylmethane

○
○
○
○
○
○
○
○

○

51 1,2-Dimethylhydrazine

陰性

○

○

42 2,6-Dichloro-p-phenylenediamine

47 Diethylstilbestrol (DES)

4

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○

○
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○
○

○

○
○

○

化学物質名

ヒトがん原物質IARC分類グループ

SHECTA結果

1陽性

2A

87 Mitomycin C2B

3○

88 Monuron○

89 2-Naphthylamine○

90 Nitrilotriacetic Acid
2-Nitro-p-phenylenediamine [2-Nitro-1,492phenylenediamine]

4

○
○
○
○

○
○

93 5-Nitro-o-toluidine [2-Amino-4-nitrotoluene]○○○

94 2-Nitropropane

陰性

○

○

N-Nitroso-N-ethylurea

97 [N-Ethyl-N-nitrosourea (ENU)] [1-Ethyl-1nitrosoruea]

98

N-Nitroso-N-methylnitroguanidine [N-Methyl-N’nitro-N-nitrosoguanidinen(MNNG)]

99 N-Nitrosodiethylamine [Diethyl nitrosamine]

○

○

○

○

○

○
○

102 4,4’-Oxydianiline○

104 Phenacetin○○

105 Phenobarbital sodium Phenobarbital○

106 Phenolpthalein○

110 β-Propionolactone○

111 Propylene oxide○

112 1,2-Propyleneimine （Propyleneimine）

○

○
○
○
○
○

113 Pyridine○

114 Reserpine○

115 p-Rosaniline (CI Basic Red 9) [Magenta]○

116 Safrole○

117 Testosterone○

120 Thioacetamide○

121 Thiourea○

122 o-Toluidine○

124 2,4,6-Trichlorophenol○

126 Urethane [Ethyl carbamate]○
物質数13153924○
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80

11