MATERIAL SAFETY DATA SHEETTransgenomic, Inc.
Effective Date: June 13, 2012
12325 Emmet Street
Document No.: MSD-70602X
Omaha, NE 68164
Revision No: 1
Emergency Phone (USA): 800-424-9300 (CHEMTREC 24hr)
Emergency Phone (UK/Europe): +44 (0)-870-190-6777 (CARECHEM24)

SECTION 1. Product Identification
Catalogue Number: 706020, 706021, 706025
Name: SURVEYOR® Mutation Detection Kit for Standard Gel Electrophoresis

SECTION 2. Composition/Information on Ingredients
Substance Name: SURVEYOR® Mutation Detection Kit for Standard Gel Electrophoresis
CAS#: None
SARA 313: NoThe hazards identified with this kit are those associated with the following
components.
706052V, 706062V, 706066V, 708025, 708030, 708033, 708040, 708050, 708060,708061
SECTION 3. Hazards Identification
Emergency Overview
CAUTION! MAY CAUSE IRRITATION TO SKIN, EYES, ANDRESPIRATORY TRACT. MAY AFFECT KIDNEYS. HARMFUL IF
SWALLOWED OR INHALED.
Potential Health Effects
Inhalation:
Due to the low vapor pressure, inhalation of the vapors at room temperatures isunlikely. Inhalation of mist may cause irritation of respiratory tract. Symptoms may
include coughing, shortness of breath.
Ingestion:
Mild alkali. Causes irritation and reddening to the mucous membranes of the mouth,esophagus, and gastrointestinal tract. Symptoms may include nausea, vomiting anddiarrhea. Large oral doses may cause weakness, collapse, blood clotting and coma.
Estimated lethal dose: 50 grams of pure TRIS solid.

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Skin Contact:
May cause irritation.
Eye Contact:
May cause irritation.
Chronic Exposure:
May cause kidney injury. Chronic dermatitis may follow skin contact.
Aggravation of Pre-existing Conditions:
Persons with pre-existing skin disorders or eye problems or impaired liver or kidney
function may be more susceptible to the effects of the substance.

SECTION 4. First Aid Measures
Inhalation:
Remove to fresh air. Get medical attention for any breathing difficulty.
Ingestion:
Induce vomiting immediately as directed by medical personnel. Never give
anything by mouth to an unconscious person. Get medical attention.
Skin Contact:
Immediately flush skin with plenty of water for at least 15 minutes. Remove
contaminated clothing and shoes. Wash clothing before reuse. Thoroughly
clean shoes before reuse. Get medical attention if irritation develops.
Eye Contact:
Immediately flush eyes with plenty of water for at least 15 minutes, lifting
upper and lower eyelids occasionally. Get medical attention if irritation
persists.

SECTION 5. Fire Fighting Measures
Fire:
Flash point: 199C (390F) CC
Autoignition temperature: 370C (698F)
Slight fire hazard when exposed to heat or flame.
Explosion:
Above flash point, vapor-air mixtures are explosive within flammable limits
noted above.
Fire Extinguishing Media:
Use any means suitable for extinguishing surrounding fire. Water spray, dry
chemical, alcohol foam, or carbon dioxide extinguishers are effective. Waterspray may be used to extinguish surrounding fire and cool exposedcontainers. Water spray will also reduce fume and irritant gases.
Special Information:
In the event of a fire, wear full protective clothing and NIOSH-approved
self-contained breathing apparatus with full facepiece operated in thepressure demand or other positive pressure mode.

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SECTION 6.

Accidental Release Measures

Ventilate area of leak or spill. Wear appropriate personal protective
equipment as specified in Section 8. Contain and recover liquid whenpossible. Collect liquid in an appropriate container or absorb with an inert
material (e. g., vermiculite, dry sand, earth), and place in a chemical waste
container. Do not use combustible materials, such as saw dust. Do not flush
to sewer!

SECTION 7. Handling and Storage
Keep in a tightly closed container, stored in a cool, dry, ventilated area.
Protect against physical damage. Isolate from incompatible substances.
Containers of this material may be hazardous when empty since they retain
product residues (vapors, liquid); observe all warnings and precautions listed
for the product.

SECTION 8. Exposure Controls/Personal Protection
Airborne Exposure Limits:
For Glycerol Mist:- OSHA Permissible Exposure Limit (PEL):
Total Dust: 15 mg/m3 (TWA);
Respirable Fraction: 5 mg/m3(TWA).
- ACGIH Threshold Limit Value (TLV):
10 mg/m3
Ventilation System:
A system of local and/or general exhaust is recommended to keep employee
exposures below the Airborne Exposure Limits. Local exhaust ventilation is
generally preferred because it can control the emissions of the contaminant at
its source, preventing dispersion of it into the general work area. Please referto the ACGIH document, Industrial Ventilation, A Manual of Recommended
Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):
If the exposure limit is exceeded and engineering controls are not feasible, ahalf face piece particulate respirator (NIOSH type P95 or R95 filters) may beworn for up to ten times the exposure limit or the maximum use
concentration specified by the appropriate regulatory agency or respirator
supplier, whichever is lowest. A full-face piece particulate respirator(NIOSH type P100 or R100 filters) may be worn up to 50 times the exposure
limit, or the maximum use concentration specified by the appropriate
regulatory agency, or respirator supplier, whichever is lowest. Please notethat N filters are not recommended for this material. For emergencies orinstances where the exposure levels are not known, use a full-face piece
positive-pressure, air-supplied respirator. WARNING: Air-purifying
respirators do not protect workers in oxygen-deficient atmospheres.

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Skin Protection:
Wear protective gloves and clean body-covering clothing.
Eye Protection:
Use chemical safety goggles. Maintain eye wash fountain and quick-drenchfacilities in work area.

SECTION 9. Physical and Chemical Properties
Appearance:
Clear oily liquid.
Odor:
Odorless.
Solubility:
Miscible in water.
Specific Gravity:
No Information FoundpH:
No Information Found% Volatiles by volume @ 21C (70F):
0Boiling Point:
219C (426F)
Melting Point:
18C (64F)
Vapor Density (Air=1):
No Information Found
Vapor Pressure (mm Hg):
No Information Found
Evaporation Rate (BuAc=1):
No information found.

SECTION 10. Stability and Reactivity
Stability:
Stable under ordinary conditions of use and storage.
Hazardous Decomposition Products:
Toxic gases and vapors may be released if involved in a fire. Glycerol
decomposes upon heating above 290C, forming corrosive gas (acrolein).
Hazardous Polymerization:Will not occur.
Incompatibilities:
Strong oxidizers. Can react violently with acetic anhydride, calcium
oxychloride, chromium oxides and alkali metal hydrides. Copper, brass, andaluminium.
Conditions to Avoid:Heat, flames, ignition sources and incompatibles.

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SECTION 11. Toxicological Information
Glycerol: oral rat LD50: 12,600 mg/kg. Investigated as a mutagen,reproductive effector.
Tris: oral rat LD50: 5900 mg/kg.
Cancer Lists
Ingredient
Glycerol (56-81-5)
TRIS (77-86-1)

Known
NoNo

NTP Carcinogen
Anticipated IARC Category
No
None
No
None

SECTION 12. Ecological Information
Environmental Fate:
When released into the soil, this material is expected to readily biodegrade.
When released into the soil, this material is not expected to evaporatesignificantly. When released into water, this material is expected to readily
biodegrade. This material is not expected to significantly bioaccumulate.
When released into the air, this material may be moderately degraded byreaction with photochemically produced hydroxyl radicals. When released
into the air, this material may be removed from the atmosphere to a moderate
extent by wet deposition.
Environmental Toxicity:
This material is not expected to be toxic to aquatic life.

SECTION 13. Disposal Considerations
Whatever cannot be saved for recovery or recycling should be managed in anappropriate and approved waste disposal facility. Processing, use orcontamination of this product may change the waste management options.
State and local disposal regulations may differ from federal disposal
regulations. Dispose of container and unused contents in accordance withfederal, state and local requirements.

SECTION 14. Transport Information
Not regulated.

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SECTION 15. Regulatory Information
Chemical Inventory Status - Part 1
Ingredient
Glycerol (56-81-5)
TRIS (77-86-1)

TSCA EC Japan Australia
Yes Yes Yes
Yes
Yes Yes Yes
Yes

Chemical Inventory Status - Part 2CanadaKorea DSL NDSL Phil.
Yes Yes
No YesYes Yes
No YesIngredient
Glycerol (56-81-5)
TRIS (77-86-1)
Federal, State & International Regulations - Part 1-SARA 302
RQ TPQ
No No
No No

Ingredient
Glycerol (56-81-5)
TRIS (77-86-1)

SARA 313
List Chemical Catg.
No
No
No
No

Federal, State & International Regulations - Part 2
Ingredient
Glycerol (56-81-5)
TRIS (77-86-1)

CERCLA
No
No

RCRA
261.33
No
No

TSCA
8(d)
No
No

Chemical Weapons Convention: No
TSCA 12(b): No
CDTA: NoSARA 311/312:
Glycerol: Acute: Yes
TRIS:Acute: Yes
Reactivity: No

Chronic: Yes Fire: No Pressure: No
Chronic: No Fire: No Pressure: No

Australian Hazchem Code: None allocated.
Poison Schedule: None allocated.
WHMIS:This MSDS has been prepared according to the hazard criteria of theControlled Products Regulations (CPR) and the MSDS contains all of theinformation required by the CPR.

SECTION 16. Other Information
NFPA Ratings: Health: 1 Flammability: 1 Reactivity: 0Label Hazard Warning:
CAUTION! MAY CAUSE IRRITATION TO SKIN, EYES, ANDRESPIRATORY TRACT. MAY AFFECT KIDNEYS. WARNING!
HARMFUL IF SWALLOWED OR INHALED. CAUSES IRRITATION TO
SKIN, EYES AND RESPIRATORY TRACT.
Label Precautions:
Avoid breathing mist.
Avoid contact with eyes, skin and clothing.
Keep container closed.

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Use with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:
If inhaled, remove to fresh air. Get medical attention for any breathingdifficulty. In case of contact, immediately flush eyes or skin with plenty ofwater for at least 15 minutes. Get medical attention if irritation develops orpersists. If swallowed, induce vomiting immediately as directed by medicalpersonnel. Never give anything by mouth to an unconscious person. If
inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. In case of contact, immediately flush eyesor skin with plenty of water for at least 15 minutes. Remove contaminatedclothing and shoes. Wash clothing before reuse. In all cases, get medicalattention.
Product Use:Laboratory Reagent.

Disclaimer:
Transgenomic, Inc. provides the information contained herein in good faith but makes norepresentation as to its comprehensiveness or accuracy. This document is intended only as aguide to the appropriate precautionary handling of the material by a properly trained personusing this product. Individuals receiving the information must exercise their independentjudgment in determining its appropriateness for a particular purpose. TRANSGENOMIC,INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR
IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECTTO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE
INFORMATION REFERS. ACCORDINGLY, TRANSGENOMIC, INC. WILL NOT BERESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON
THIS INFORMATION.

Transgenomic, Inc.
12325 Emmet Street
Omaha, NE, USA 68164
Phone: (402) 452-5400
FAX: (402) 452-5401

Transgenomic, Ltd.
UK - Glasgow
40 Watt Road
Hillington Park
Hillington, Glasgow, UK G52 4RY
Phone: +44 (0)141 892 8800
FAX: +44 (0)141 883 5967

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