December 13, 2023
Eisai Co., Ltd.
Mizuho Bank, Ltd.

Eisai and Mizuho Sign Sustainability-Linked Loan Agreement
Eisai Co., Ltd. (CEO: Haruo Naito, “Eisai”) and Mizuho Bank, Ltd. (President & CEO:
Katsuhiko Kato, “Mizuho Bank”) announced today that the companies have signed asustainability-linked syndicated loan agreement ("the agreement"), which comes into effecttoday.
Sustainability-linked loans are a type of loan which incentivizes borrowers to achievesustainability performance targets (“SPTs”) by linking borrowing terms and conditions, suchas interest rates, to the achievement of the SPTs, seeking to drive environmental and sociallysustainable economic activities and economic growth.
Under the concept of human health care (hhc), Eisai aims to effectively achieve social goodin the form of relieving anxiety over health and reducing health disparities. through activities
such as innovative drug discovery in the fields of dementia, cancer, and global health.
Particularly in the domain of dementia, Eisai has developed “LEQEMBI®”, a new drug for
Alzheimer’s disease(AD), which obtained approval in the US and Japan this year. By
delivering LEQEMBI to people with early AD around the world, Eisai aims not only to improvetheir health outcomes but also contribute to address social issues regarding AD, including
long term nursing care.
Eisai has set social impact targets for LEQEMBI in the U.S. and Japan based on its social
value in terms of its effects on health outcomes and on cost reductions in nursing care andother expenses, and has established these as the SPTs of this agreement. With the funds
raised through this agreement, Eisai will promote the creation of social impact through theelimination of diseases of poverty (neglected tropical diseases, malaria, tuberculosis, etc.),
in addition to the establishment of programs to offer LEQEMBI to low-income populations forfree in the U.S. and emerging countries, and the building of dementia ecosystems.
This agreement has undergone a third-party review* by Rating and Investment Information,
Inc. (R&I) regarding its compliance with the Sustainability-Linked Loan Principles issued by
the Loan Market Association and other organizations, as well as the Green Loan andSustainability-Linked Loan Guidelines issued by Japan’s Ministry of the Environment.
Mizuho Bank is committed to the Mizuho group's purpose of “proactively innovate together
with our clients for a prosperous and sustainable future”, with the desire to co-create aprosperous future with clients by supporting their endeavors and challenging ourselves.
Mizuho’s new medium-term business plan, which began in FY2023, is a three-year journeyconnecting various initiatives and co-creating value-added solutions in order to support ourclients and solve social issues. As part of this, we are seeking out ways to have positive socialimpacts in areas such as realization of a more inclusive society and improvement in Japan’sglobal competitiveness.
Mizuho Bank's role in connecting initiatives and creating social impact and outcomes is tosupport sustainability transformation from multiple angles by working together to findsolutions for the development of clients and society from a medium- to long-term perspective.
Mizuho Bank will continue working together with our clients to achieve sustainability
transformation by providing sustainable finance that creates a flow of funds to addressenvironmental and social issues, and by providing solutions that utilize knowledge andfunctions that go beyond finance.
Overview of Loan Terms
Borrower: Eisai
Method: Syndication
Arranger: Mizuho Bank
Lenders: 39 financial institutions
Loan amount: 50 billion yen
Agreement date: December 6, 2023
Drawdown date: December 13, 2023
* Please refer to the opinion provided by Rating and Investment Information, Inc. (R&I).
https://www.r-i.co.jp/en/rating/esg/sustainabilityfinance/index.html

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