ProgramFRIDAY, OCTOBER 3008:30 am –08:55 amRegistrationWelcome Remarks (T. Nakayama and A. Radbruch)Session I: Relation of circulating and resting memory (9:00 am – 10:00 am)Chair: Toshinori Nakayama, Hiroshi Kiyono09:00 – 09:20 amAndreas RadbruchDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, GermanyCharité University Medicine, Berlin, Germany“The bone marrow as a special place for maintenance ofimmunological memory”09:20 – 09:40 amFederica SallustoCellular Immunology Laboratory and Center of Medical Immunology, Institutefor Research in Biomedicine, University of Italian Switzerland, Bellinzona,Switzerland“Functional heterogeneity of human memory CD4+ T cells inhealth and disease”09:40 – 10:00 amKoji TokoyodaDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany“B cells suppress the establishment of CD49b+T-bet+ restingmemory T helper cells in the bone marrow”Coffee break (10:00 am – 10:20 am)Session II: Formation of memory T cells (10:20 am – 11:40 am)Chair: Alf Hamann, Stephen P. Schoenberger10:20 – 10:40 amDerk AmsenSanquin and Landsteiner Laboratory for Blood Research, Amsterdam,Netherlands“A central role for Notch in effector CD8+ T cell differentiation”10:40 – 11:00 amAndreas HutloffDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany“Generation and maintenance of antigen-specific memory T and Bcells in the lung”11:00 – 11:20 amDavid R. WithersMRC Centre for Immune Regulation, College of Medical and Dental Sciences,University of Birmingham, Birmingham, UK“Costimulatory molecules in the formation of memory CD4 T cells”11:20 – 11:40 amJulia K. PolanskyDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany“Epigenetic reprogramming during memory formation of humanCD4+ T cells”Poster session & Lunch break (11:40 am – 1:40 pm)	  	  	  Session III: What keeps memory cells alive? (1:40 pm – 3:00 pm)Chair: Fritz Melchers, Nobuo Sakaguchi01:40 – 02:00 pmVeit R. BuchholzInstitute for Medical Mircrobiology, Immunology and Hygiene; TechnischeUniversität München (TUM), Munich, Germany“The smallest unit: How individual T cells generateimmunological memory”02:00 – 02:20 pmStephen P. SchoenbergerLaboratory of Cellular Immunology, La Jolla Institute for Allergy andImmunology, La Jolla CA, USA“New insights into T help for CTL: Immunogen dose and thedichotomous role of CD4+ T cells as TH and TReg”02:20 – 02:40 pmAnja E. HauserDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany“Dynamics of bone marrow survival niches for long-lived plasmacells”02:40 – 03:00 pmKoji YasutomoDepartment of Immunology, Graduate School of Medicine, TokushimaUniversity, Tokushima, Japan“Maintenance of memory T cell by Notch”Coffee break (3:00 pm – 3:20 pm)Session IV: Formation of memory B cells (3:20 pm – 4:40 pm)Chair: Klaus Rajewsky, Claudia Berek03:20 – 03:40 pmDaisuke KitamuraDivision of Molecular Biology, Research Institute for Biomedical Sciences,Tokyo University of Science, Noda, Japan“IL-9 as a positive regulator of memory B cells”03:40 – 04:00 pmClaude-Agnès ReynaudInstitut Necker-Enfants Malades, INSERM U1151-CNRS UMR 8253,Faculté de Médecine Paris Descartes, Paris, France“A mucosal-derived systemic B-cell memory response in nonimmunized mice”04:00 – 04:20 pmTomohiro KurosakiLaboratory of Lymphocyte Differentiation, WPI Immunology FrontierResearch Center, Osaka University, Osaka, JapanLaboratory for Lymphocyte Differentiation, RIKEN Center for IntegrativeMedical Sciences (IMS), Yokohama, Japan“Instructive selection of germinal center B cells into the memorycompartment”04:20 – 04:40 pmMichael G. McHeyzer-WilliamsDepartment of Immunology and Microbial Science, The Scripps ResearchInstitute, La Jolla, USA“Deconstructing B cell memory at the single cell level”Coffee break (4:40 pm – 5:00 pm)	  	  	  Session V: Pathogenic memory in chronic inflammation (5:00 pm – 6:00 pm)Chair: Michael G. McHeyzer-Williams, Sergei Nedospasow5:00 – 5:20 pmFalk HiepeCharité – University Medicine Berlin, Berlin, GermanyDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, Germany“Selective depletion of memory plasma cells secretingpathogenic autoantibodies”5:20 – 5:40 pmToshinori NakayamaDepartment of Immunology, Graduate School of Medicine, Chiba University,Chiba, Japan“Pathogenic Th2 (Tpath2) cells in airway inflammation”5:40 – 6:00 pmSimon FillatreauDeutsches Rheuma-Forschungszentrum Berlin (DRFZ), Berlin, GermanyInstitut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253,Paris, FranceUniversité Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris,FranceAssistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Necker EnfantsMalades, Paris, France“Regulation of secondary immune responses to bacterial pathogens”Keynote lecture (6:00 pm)Chair: Joachim. R. Kalden, Hiromi KubagawaMark J. ShlomchikUniversity of Pittsburgh School of Medicine, Pittsburgh, USA“Heterogeneity of B cell responses: The long and short of it”Get together (7:00 pm)SATURDAY, OCTOBER 31Session VI: Vaccination: a way to generate memory (9:00 am – 10:40 am)Chair: Britta Siegmund, Birgit Sawitzki09:00 – 09:20 amKen J. IshiiCenter for Drug Design Research, National Institutes of Biomedical Innovation,Health and Nutrition (NIBIOHN), Osaka, JapanLaboratory of Vaccine Science, WPI Immunology Frontier Research Center(IFREC), Osaka University, Osaka, Japan“Immuno-targeting of airway mucosa, skin layers and tumormicro-environment by novel adjuvants”09:20 – 09:40 amStefan H.E. KaufmannMax Planck Institute for Infection Biology, Berlin, Germany“Immunity against tuberculosis in response to natural infection orvaccination”09:40 – 10:00 amHiroshi KiyonoInternational Research and Development Center for Mucosal Vaccines,Division of Mucosal Immunology, Department of Microbiology andImmunology, The Institute of Medical Science, The University of Tokyo, Tokyo, JapanDepartment of Immunology, Graduate School of Medicine, Chiba University,Chiba, Japan“Nanogel based nasal vaccine for the prevention ofStreptococcus pneumonia infection”	  	  	  10:00 – 10:20 amBehazine CombadièreCentre d’Immunologie et des maladies infectieuses CIMI-Paris Inserm 1135and UPMC, Paris, France“Deciphering complexity of immune memory after infection andvaccination”10:20 – 10:40 amMoriya TsujiAaron Diamond AIDS Research Center, The Rockefeller University,New York, USA“Testing immunogenicity and protective efficacy of humanmalaria vaccines in human immune system (HIS) mice”Coffee break (10:40 am – 11:00 am)Session VII: Protective memory in infection immunology (11:00 am – 12:40 pm)Chair: Stefan H.E. Kaufmann, Alexander Scheffold11:00 – 11:20 amKiyoshi TakedaDepartment of Microbilogy and Immunology, Graduate School of Medicine,WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan“Maintenance of gut homeostasis by intestinal epithelial cells”11:20 – 11:40 amStephen J. McSorleyUniversity of California Davis, Davis, USA“Amplifying protective CD4 T cell responses to bacteria”11:40 – 12:00 pmJun KunisawaLaboratory of Vaccine Materials, National Institutes of Biomedical Innovation,Health and Nutrition (NIBIOHN), Osaka, JapanDivision of Mucosal Immunology and International Research andDevelopment Center for Mucosal Vaccine, Institute of Medical Science, TheUniversity of Tokyo, Tokyo, Japan“Environmental factors regulate the function of IgA-producingcells in the gut”12:00 – 12:20 pmAnna Katharina SimonWeatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK“Autophagy and immunological memory”12:20 – 12:40 pmFumihiko IshikawaLaboratory for Human Disease Models, RIKEN Center for Integrative MedicalSciences, Yokohama, Japan“Understanding in vivo kinetics of human hematopoieticstem/progenitor cells”12:40 pmClosing Remark (H. Kiyono)