日本香粧品学会誌

Vol. 38,カチオン性化合物との複合化による
No. 1, pp. 9–14（2014）「DOEP」の毛髪吸着性能とケア効果の向上

9〈一般論文〉

カチオン性化合物との複合化による「2-（Dimethyldocosylammonio）ethylOctadecyl Ethyl Phosphate」の毛髪吸着性能とケア効果の向上
大 川洋 *, 1, 2，英謙 二 2，鈴 木 正 浩 2，関 根 愛 実 1，福 井 洋 樹 1

Development of Hair Adsorption and Care Effects by Hybridization of a CationicCompound and「2（Dimethyldocosylammonio）
ethyl Octadecyl Ethyl Phosphate」
Hiroshi OKAWA*, 1, 2, Kenji HANABUSA2, Masahiro SUZUKI2, Yoshimi SEKINE1, Hiroki FUKUI1（Accepted: August 28, 2013）

Abstract
2-（Dimethyldocosylammonio）ethyl octadecyl ethyl phosphate（DOEP）is a gemini compound bearing a phosphorylcholine-like moiety. It is well known that gemini compounds exhibit excellent surface activity and a high tendency to selfassemble. Furthermore, the phosphoryl choline moiety is highly biocompatible. Therefore, we expect DOEP to combine theadvantages of the phosphoryl choline group and that of gemini compounds. In a previous study, we showed that the compound self-assembled to form nanosized vesicles in water. The compound was also shown to be beneﬁcial for both skin andhair. In this study, we have tried to improve the absorption of DOEP by hair in order to enhance its beneﬁcial effects. A formulation of DOEP and a cationic compound（DOEP-BTC）was prepared in order to obtain positively charged DOEP. We
expect the positively charged DOEP to be electrostatically attracted to the negative charges in hair. We compared the efﬁcacyof absorption, physicochemical properties, and beneﬁcial effects of a DOEP dispersion（DOEP-Dis）and DOEP-BTC. The
surface charge and particle size of the dispersions were measured to determine the effect of the addition of the cationic compound. The surface charge of DOEP-Dis and DOEP-BTC were determined to be ＋3.2 mV and ＋42.3 mV, respectively. Theparticle size of DOEP-Dis and DOEP-BTC were estimated to be 292±192 nm and 110±62 nm respectively. These facts indicated that the addition of the cationic compound increased the surface charge of DOEP（almost neutral to positive）．In addition, it resulted in a smaller particle size of the dispersion. As a result, the absorption efﬁcacy of DOEP-BTC was aboutﬁve times greater than the absorption efﬁcacy of DOEP-Dis. The beneﬁcial effects were evaluated in terms of the smoothness, elasticity, and moisture content of hair. Compared to DOEP-Dis, DOEP-BTC showed improved beneﬁcial effects on allcounts. We presumed that the difference in the beneﬁcial effects was due to a difference in the amounts of DOEP absorbedby the hair. These results showed that the combination of DOEP and the cationic compound was absorbed better by the hairand resulted in enhanced beneﬁcial effects.
Key words:

1.

緒gemini compound, cationic compound, surface charge, hair absorption, hair care.

ルチラメラベシクルを形成する優れた分子会合性能を有言すること，毛髪と皮膚の双方にケア効果を発現すること

2-（Dimethyldocosylammonio）ethyl octadecyl ethyl phos-を見いだしている1）。

phate（以下，DOEP）は親水基にホスホリルコリン（以ところで，毛髪用化粧料には，ダメージにより低下し下，PC）類似基を有するジェミニ型化合物である。わた滑り性やツヤ感などの毛髪質感の改善を目的として，れわれは，DOEP が高界面活性能や高会合性能で知られさまざまなケア成分が配合されている。毛髪への吸着はるジェミニ型化合物と，優れた生体適合性を発現する毛髪ケア成分が効果を発現するうえで必須の機能であるPC 基の特長を併せ持つ有益な化合物であると考え，基が，その吸着性能は毛髪とケア成分の物理化学的な相互礎物性，および香粧品原料としての有用性評価を行って作用に依存する2）。毛髪は最外層が F 層と呼ばれる脂質いる。これまでに，同化合物が水中でリポソーム様のマ層であり3），ケラチンタンパク質を構成する酸性タンパ

1,2* 日油株式会社ライフサイエンス研究所〒300–2635 茨城県つくば市東光台 5–10
連絡先 E-mail: hiroshi_ohkawa@nof.co.jp
信州大学大学院総合工学系研究科〒386–8567 長野県上田市常田 3–15–1

1,2* Life Science Research Laboratory, NOF CORPORATION （5–10Tokodai, Tsukuba, Ibaraki 300–2635, Japan）
Graduate School of Science and Technology, Shinshu University（3–15–1 Tsuneda, Ueda, Nagano 386–8567, Japan）