2024 年 9 ⽉ 26 ⽇現在

⽜丸 理⼀郎Richiro Ushimaru, Ph.D.

1988 年 8 ⽉ 13 ⽇⽣

学歴・職歴
2011 年 3 ⽉

名古屋⼤学理学部化学科卒業
野依 良治 教授

2013 年 3 ⽉

名古屋⼤学⼤学院理学研究科物質理学専攻（化学系）修⼠課程修了
野依 良治 教授

2019 年 12 ⽉

Ph. D., Department of Chemistry, The University of Texas at Austin
Prof. Hung-wen (Ben) Liu

2020 年 1 ⽉

東京⼤学⼤学院薬学系研究科・助教、現在に⾄る2020 年 10 ⽉

JST 戦略的創造研究推進事業 ACT-X「⽣命と化学」研究者（兼任）2022 年 11 ⽉

令和４年度 東京⼤学卓越研究員

2024 年 10 ⽉

JST 創発的研究⽀援事業（有⽥パネル）研究者（兼任）受賞歴2018 年 9 ⽉

Research Excellence Award (The University of Texas at Austin)

2018 年 9 ⽉

Leon O. Morgan Fellowship (The University of Texas at Austin)

2020 年 7 ⽉

⽇本薬学会 ⽣薬天然物部会奨励賞

2022 年 3 ⽉

⽇本化学会 第 35 回 若い世代の特別講演証

2023 年 6 ⽉

第 24 回 酵素応⽤シンポジウム 研究奨励賞

2023 年 6 ⽉

⽇本⽣薬学会 学術奨励賞

2023 年 7 ⽉

第 22 回 天然物化学談話会 奨励賞

2024 年 3 ⽉

⽇本薬学会 奨励賞

2024 年５⽉

化学情報協会 JAICI 賞

2024 年５⽉

酵素⼯学研究会 酵素⼯学奨励賞

学術論⽂リスト
1. Ushimaru, R., et al., “TBA.” Nature Catalysis, in revision (2024)
2. Awakawa, T., Mori, T., Barra, L., Ahmed, Y., Ushimaru, R., Gao, Y., Adachi, N., Senda,T., Terada, T., Tantillo, D. J., Abe, I. “The structural basis of pyridoxal 5’-phosphate
dependent b-NAD alkylating enzyme.” Nature Catalysis 7, in press (2024)
3. Wenger, E., Martinie, R., Ushimaru, R., Pollock, C., Sil, D., Li, A., Hoang, N., Palowitch,G., Graham, B., Schaperdoth, I., Burke, E., Maggiolo, A., Chang, W.-C., Allen, B., Krebs,C., Silakov, A., Boal, A., Bollinger, J. M. Jr, “Optimized substrate positioning enables
switches in C–H cleavage site and reaction outcome in the hydroxylation-epoxidation1

2024 年 9 ⽉ 26 ⽇現在

sequence catalyzed by hyoscyamine 6β-hydroxylase.” J. Am. Chem. Soc. 146, 2427124287 (2024)
4. Zhou, L., Awakawa, T., Ushimaru, R., Kanaida, M., Abe, I., “Characterization of
aziridine-forming a-ketoglutarate-dependent oxygenase in L-isovaline biosynthesis.”
Org. Lett. 26, 724-727 (2024)
5. Ushimaru, R.,* Cha, L., Shimo, S., Li, X., Paris, J., Mori, T., Miyamoto. K., Coffer, L.,
Uchiyama, M., Guo, Y.,* Chang, W-c.,* Abe, I.* “Mechanistic analysis of thestereodivergent nitroalkane cyclopropanation catalyzed by nonheme iron enzymes.”
J. Am. Chem. Soc. 145, 24210-24217 (2023)*co-corresponding author
6. Ushimaru, R.,* Ding, Y., Mori, T., Miyamoto, K., Uchiyama, M., Abe, I.* “Structural andmechanistic insights into the C–C bond forming rearrangement reaction catalyzed byheterodimeric hinokiresinol synthase.” J. Am. Chem. Soc. 145, 21966-21973 (2023)*co-corresponding author
7. Ushimaru, R.,* Lyu, J., Ling, M., Abe, I.* “Multiple C–C bond cleavage reactionscatalyzed by tolyporphin tetrapyrrole biosynthetic enzymes.” J. Am. Chem. Soc. 145,9834-9839 (2023)*co-corresponding author
8. Ueno, K., Ushimaru, R.,* Abe, I.* “Photoinduced reductive dehalogenation of phenacyl
bromides with pyridoxal-5′-phosphate.” Chem. Pharm. Bull. 71, 675-677 (2023)*co-corresponding author
9. Tao, H.,† Ushimaru, R.,†,* Awakawa, T., Mori, T., Uchiyama, M., Abe, I.*“Stereoselectivity and substrate specificity of the Fe(II)/α-ketoglutarate-dependentoxygenase TqaL.” J. Am. Chem. Soc. 144, 21512-21520 (2022)†co-first author, *co-corresponding author
10. Li, X., Chen, H.-P., Zhou, L., Fan, J., Awakawa, T., Mori, T., Ushimaru, R.,* Abe, I.,*Liu, J.-K.* “Cordycicadins A–D, antifeedant polyketides from the entomopathogenic
fungus Cordyceps cicadae JXCH1.” Org. Lett. 23, 8627–8632 (2022)*co-corresponding author
11. Lyu, J., Ushimaru, R.,* Abe, I.* “Characterization of enzymes catalyzing the initial stepsof the β-lactam tabtoxin biosynthesis.” Org. Lett. 24, 3337-3341 (2022)*co-corresponding author
12. Shimo, S.,† Ushimaru, R.,†,* Engelbrecht, A., Harada, M., Miyamoto, K., Andreas, K.,
Uchiyama, M., Kaysser, L.,* Abe, I.* “Stereodivergent nitrocyclopropane formation
during biosynthesis of belactosins and hormaomycins.” J. Am. Chem. Soc. 143, 1841318418 (2021)†co-first author, *co-corresponding author22024 年 9 ⽉ 26 ⽇現在

13. Mori, T., Zhai, R., Ushimaru, R., Matsuda, Y., Abe, I. “Molecular insights into theendoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI.” Nature Commun.
12, Article number: 4417 (2021)
14. Ushimaru, R., Chen, Z., Zhao, H., Fan, P.-h., Liu, H.­w. “The enzymes mediating
maturation of the seryl-tRNA synthetase inhibitor SB-217452 during biosynthesis ofalbomycins.” Angew. Chem. Int. Ed. 59, 3558-3562 (2020)
15. Wang, S. A., Lin, C. I., Zhang, J., Ushimaru, R., Sasaki, E, Liu, H.-w. “Studies oflincosamide formation complete the biosynthetic pathway for lincomycin A.” Proc. Natl.
Acad. Sci. USA 116, 24794-24801 (2020)
16. Ushimaru, R., Liu, H.­w. “Biosynthetic origin of the atypical stereochemistry in thethioheptose core of albomycin nucleoside antibiotics.” J. Am. Chem. Soc. 141, 22112214 (2019)17. Ushimaru, R., Ruszczycky, M. W., Liu, H.­w. “Changes in regioselectivity of H atom
abstraction during the hydroxylation and cyclization reactions catalyzed byhyoscyamine 6β-hydroxylase.” J. Am. Chem. Soc. 141, 1062-1066 (2019)18. Ushimaru, R., Ruszczycky, M. W., Chang, W.-c., Yan, F., Liu, Y.-n., Liu, H.­w.
“Substrate conformation correlates with the outcome of hyoscyamine 6β-hydroxylase
catalyzed oxidation reactions.” J. Am. Chem. Soc. 140, 7433-7436 (2018)19. Ushimaru, R., Nishimura, T., Iwatsuki, T., Naka, H. “A fluorinated cobalt(III) porphyrin
complex for hydroalkoxylation of alkynes.” Chem. Pharm. Bull. 65, 1000-1003 (2017)20. Ushimaru, R., Lin, C.-I., Sasaki, E., Liu, H.­w. “Characterization of enzymes catalyzing
transformations of cysteine S-conjugated intermediates in the lincosamide biosynthetic
pathway.” ChemBioChem. 17, 1606-1611 (2016)
21. Tsarev, V. N., Morioka, Y., Caner, J., Wang, Q., Ushimaru, R., Kudo, A., Naka, H., Saito,
S. “N-Methylation of amines with methanol at room temperature.” Org. Lett. 17, 25302533 (2015)
22. Tachinami, T., Nishimura, T., Ushimaru, R., Noyori, R., Naka, H. “Hydration of terminal
alkynes catalyzed by water-soluble cobalt porphyrin complexes.” J. Am. Chem. Soc.
135, 50-53 (2013)

著書・総説
1. Ushimaru, R.,* Abe, I.* “TBA” Chem. Soc. Rev., in preparation (2024)*co-corresponding author
2. Ushimaru, R.* "Functions and mechanisms of enzymes assembling lignans andnorlignans." Curr. Opi. Chem. Biol. 80, 102462 (2024)

3

2024 年 9 ⽉ 26 ⽇現在

3. Ushimaru, R.* “Three-membered ring formation catalyzed by a-ketoglutaratedependent nonheme iron enzymes.” J. Nat. Med. 78, 21-32 (2024)
4. Ushimaru, R.* "Characterization of enzymes catalyzing unusual C–C bond formationand cleavage reactions during natural product biosynthesis." Chem. Pharm. Bull. 72,241-247 (2023)
5. Ushimaru, R.,* Abe, I.* “Back-to-back cycloadditions in nature.” Nature Chemistry 15,1056-1057 (2023)*co-corresponding author
6. Ushimaru, R.,* Abe, I.* “Assembling neuroactive alkaloids.” Nature Plants 9, 19461947 (2023)*co-corresponding author
7. Ushimaru, R.,* Abe, I.* “Unusual dioxygen-dependent reactions catalyzed by nonheme
iron enzymes in natural product biosynthesis.” ACS Catalysis 13, 1045-1076 (2023)*co-corresponding author
8. Ushimaru, R.,* Abe, I.* “C–N and C–S bond formation by cytochrome P450 enzymes.”
Trends in Chemistry 5, 526-536 (2023)*co-corresponding author
9. Ushimaru, R.,* Lyu, J., Abe, I.* “Diverse enzymatic chemistry for propionate side chaincleavages in tetrapyrrole biosynthesis.” J. Ind. Microbiol. Biotechnol. 50, Article
number: kuad016 (2023)*co-corresponding author
10. Awakawa, T., Mori, T., Ushimaru, R., Abe, I. “Structure-based engineering of αketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis.” Nat. Prod.
Rep. 40, 46-61 (2023)
11. 森貴裕, ⽜丸理⼀郎，「これからの天然物化学に向けて」⽉刊ファインケミカル, 51,5-10 (2023)
12. ⽜丸理⼀郎,「⾶翔する若⼿研究者︓天然物の三員環構造をつくる鉄酵素の機能解析」
化学と⼯業, 75, 820 (2022)
13. ⽜丸理⼀郎,「期待の若⼿」ファルマシア, 57, 665 (2021)

4