Laboratory and Epidemiology Commumications
SuⅣeillance of Poliovims‑Isolates in J叩an, 2000

Tetsuo Yoneyama*, Kenji Sakael, Junichi Baba2, Takashi Nakayama3,Katsumi Chijiwa4, Kazuhiro Kizoe5, Hideaki Shimizu6, Setsuko Iizuka7,

TohruIshizaki8, Reiko Kondo9 and Tatsuo Miyamura
Departmen i of Virology II, National Institute ofInfectious Diseases,
Musash imurayama 208‑0011,
1Aichi Prefectural Institute of Public Health, Nagoya 462‑0032,
2Fukuoka Cio, Institutefor Hygiene and Environment, Fukuoka 81 0‑0065,
3Toyama Institute ofHealth, Toyama 939‑0363,
4Fukuoka Institute ofHealth and Environmental Sciences, Fukuoka 818‑0135,
5MlyaZaki Pylefectural Institute for Public Health and Enviy10nment, Miyazaki 889‑2 1 55,
6public Health ReseayICh Institute of the CiO, ofKawasaki, Kawasaki 210‑0834,
7shimane Prefectural Institute of Public Health and EnviT10nmental Science, Shimane 690‑0122,
8Kyoto Prefectural Institute ofHygienic and Environmental Sciences, Kyoto 612‑8369 and9Ehime Prefectural Institute of Public Health, Ehime 790‑0003
Communicated by Tatsuo Miyamura(Accepted May 9, 2001)

In 2000, 14 polioviruses were isolated from nine clinicalstrains. One vaccine‑associated paralytlC poliomyelitis

patients and three healthy individuals among nine prefectures(VAPP) case in Miyazaki Prefecture (case 5) was a 37‑year‑in Japan. These isolates were sent to National Institute ofold male with unknown vaccination history. His daughter had

Infectious Diseases (NIID) and subjected to intratypic differ‑received a second administration of oral poliovims vaccine

entiation by PCR‑restriction fragment length polymorphism(OPV) 23 days before the o.nset of his paralysis (case 10)･
Antigemically type 3 poliovlruSeS, With Sabin 3 in the VPlregion and Sabin 1 in 3D, were isolated from both the father'S

method developed by Dr. Radu Crainic (1). As showninTable
1, all of the examined polioviruses were vaccine‑derived

and the daughter's stool specimens, indicating that the daughter*Corresponding author: E‑mail:tyoneyam@nih.go.jp, Tel: +8 1 ‑was the source of infection.

Pohomyelitis cases in Japan from 1970 to 2000 are surrma‑

42‑561‑0771, Fax: +811421561‑4729

80Jpn. J. Infect. Dis., 54, 2001
rized in Table 2. Followlng the report of fatal encephalopathyof the same year.

(case 4) aRer administratiop of OPV in Fukuoka Prefecture,

On 29 October 2000 in Kyoto, the Commission for thepolio immunization practlCeS in Japan were temporarily

Certification of Poliomyelitis Eradication in the Westem
Pacific Region certified that the WHO Westem PaciflC region

ceased because of safetyconcems. A total of nine polioviruses
were isolated from seven neurologlCal cases including four

was free of indigenous wild poliovirus transmission (2). In

transient paralysIS Cases during April and May of 2000.

three reglOnS, Africa, East Mediterranean, and South East

However, no polioviruS‑positive acute flaccid paralysis Was

Asia, Wild poliovimses are still circulating. The 2000 ouぬreakreported a洗er the resumptlOn Of OPV immunization in autumn

caused by circulation of vaccine‑derived poliovims in Haiti

Table 1. Characterization ofpoliovirus isolates in 2000
Date or vaccination

Ea.?c code Age Sex

inthepatient

inthePRaI^C.Of pD.aleJだn S..1ninlc^anI;n ser｡typc

area

Onset

SamplinglYF

99‑6‑21200‑Fukuoka‑ 16MF

99‑ll‑2

300‑Tbyama‑ 17MF99‑9‑133Y

ド00‑4‑400‑4‑ I 800‑4‑24100‑Aichi‑ 199‑1 0‑799‑12‑1

diagnosisu‑̀U■Jr}禁慧聖

diffcrentiation

99‑10‑12Healthy

Polio‑2

Vaccine‑like

99‑12‑9

D i arrhea

Polio‑ 1ⅥlCCinC‑like

99‑12‑17

Healthy

Polio‑2

Vaccincll ike

En ccphal ophath y

Polio‑3

Vaccine‑like400‑ Fukuoka‑2500‑Miyazaki‑ 1Unknown

00‑5‑ 1 900‑5‑25

Poliomyelitis

Polio‑3

ⅥlCCine‑like

600‑Kawasaki‑ IIY

ド00‑5‑15 (2nd)00‑5‑ 1 900‑5‑22

Transient paralysIS

Pot i0‑3Vaccine‑I ike

700‑Stlimane‑ 1IY

F00‑4‑27 (2nd)00‑5‑ I 800‑5‑23

Transient paralysIS

Polio‑3ⅥlCCine‑1 ike

F00‑5‑1600‑5 ‑2600‑6‑2Transient paralysIS

Polio‑3Vaccine‑like00‑5‑1600‑5‑19

Transient paralysis

Pori0‑2 &3

Vaccitle‑like00‑6‑5Healthy

Polio‑3Vaccine‑likeEncephalitis

Polio‑1 &2ⅥlCCine‑likeDi arrhca

Polio‑2Vaccine‑like837Y00‑Amagasaki‑I

900‑Kyot0‑

11000‑Miyazaki‑21100‑Ehime‑

12

1100‑Kyot0‑2MIY
1Y

F00‑4‑41MF00‑4‑26 (ュnd)6M

M00‑5‑1 23M

M00‑ 500‑5‑ 1 700‑5‑2600‑5‑20

Table 2･ Annual incidence of typical poliomyelitis ( I 97012000)
No. of cases
No. of cases wi血indicated serotypcs

Year T..al

聖讐聖;f^o̲r f̲o!.禦iru̲S"^12

3 1,3 il3㌦,2,3

virus isolation positive cases
0ノ 0ノ 0ノ 凸7 9

7 7 7 7 70 1 2 tJ 4

1 1 11 1

5 2 2 ′0 つJ 1 l･2

21‑42一一2 l

trIIlIllLl

1 1 ‑ 1 lIl ‑ IIll1ll 一 ll1Illl 】 】 ‑ 】 ll 一

*2 2 エリ つJ l 1 2252102

1975

1976
1977
1978
1979
1980
00000
l 一l 1 I 1 9 凸7 0ノ 0ノ nフ

1 2 tJ 4 54440201

4201010000001■1 ‑ 】 1 ‑ ‑ lt 一 l【 ‑ 一 llI1IIIl 】 lll 一 llIl

一一21‑l 一l 【l一 一 l 一 lIIIl ‑ l

2 1 lIIIl ‑ lI】 ‑ 一 ll ‑ lll 】

40201

1986
1987

01988

01989

01990

0

1991

11992

21993

31994

1

1995

0002

1996

1997
1998
1999

02000

1

* : Non‑vaccine‑likeIIl 2 lIJlIll

2 tJ 1 0 0 2 0一‑2310 0201

】 1 l 一 lI 一 ‑I1lIrJlr ‑ ll

I‑ l ‑ l 】 ‑ l 】 l 】

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