Keio UniversityCenter
Director
Kenya Honda

Human Biology‐Microbiome‐Quantum Research Center (Bio2Q)

Kenya Honda has innovated microbiome analysis by integrating germ‐free animal models, anaerobic bacterial culture, andmetagenomic studies and has made seminal contributions to elucidating the role of the microbiome in inflammatory
diseases and cancer. The Bio2Q center will collect data on how multiple organs and the microbiome interact in disease,development, and aging, and it will use artificial intelligence and quantum computing to develop a new life science thatwill help us better understand human health.

MissionResearch

Microbiome: the collection of all microbes within an ecosystem

Human health is maintained by complex interactions between multiple organs. These
interactions include the microbiome, which exists on every external surface of the body,and the resulting information is processed and utilized in a coordinated manner.

1.

Accumulate multiomics data from humans
and model organisms and compile a
multidimensional database.

Our center will develop novel research techniques to understand the interactions
between multiple organs and the microbiome and develop methods to apply quantum
computing to human biology. Our mission is to forge a new interdisciplinary research areathat will lead to groundbreaking progress in elucidating the regulatory mechanisms
sustaining human health. In the long term, we will develop new prophylactic/therapeutic
approaches to promote healthy longevity.

2.

Elucidate the structure and function ofmicrobiome‐derived metabolites.

3.

Refine imaging metabolomics andstructural biology to promote in situ
functional analysis of metabolites in organs
and cells.

4.

Develop quantum computing‐based algorithms and pipelines to analyze theinteractions between multiple organs and microorganisms.

5.

Model the interface between the environment and the human body by advancing
organoid technology and animal models and elucidate the mechanisms underlying
the conversion of external factors into internal signals.

6.

Leverage connectomics and structural biology to understand the dynamic multiorganinteractions, including gut‐brain communication.

Identities World leaders in microbiome research, organoid technology, metabolic analysis,
neural circuit analysis, and quantum computing Integration of cutting‐edge technologies of the three research core units, theMultidimensional data analysis core, the Homeodynamics mechanistic analysis core,
and the Quantum computing core, to promote fusion research Application of Artificial Intelligence (AI) and quantum computing to further theunderstanding of human biology
 Comprehensive, longitudinal clinical samples related to cancer, diabetes, obesity,
neuropsychiatric disorders, developmental disorders, immune disorders, aging, andcentenarians

Collaborations
Exchange of researchers,
knowledge, data,samples, and expertise A joint cross‐disciplinary graduate English program between the Graduate School ofMedicine, Graduate School of Pharmaceutical Sciences, and Graduate School of
Science and Technology (STaMP)

Scientific excellence

STaMP program

New cross‐disciplinary
paradigms(Science and Technology, and Medicine, Pharmacy)