Osaka University Premium Research Institute for Human Metaverse Medicine (PRIMe)
DirectorKoji Nishida

Conquering all diseases is an ambitious goal that has persisted throughout human history. To achieve this goal,
we will establish a WPI center that will create a completely new scientific field, Human Metaverse Medicine,which integrates organoid‐based biomedical science with information and mathematical sciences for the firsttime to comprehensively and continuously understand the processes leading to disease onset that occurs ineach individual human body.
Organoid: a miniature three-dimensional tissue that mimics an organ of human or others

MissionMany of unsolved diseases are caused by complex interactions
between genetic and environmental factors. “How do suchcomplex interactions cause diseases in human body?” is thekey question in biology.

Research
Physicalenvironment
macroscopic data
representing
phenomena

Cyber
Development of analyzable
machine learning frameworkobservation

organsmolecules

Biodigitaltwin

Mechanistic
modeling
outcomesorganoids
cells

Digital twin: a computer reproduction of real-world object using various data collected from reality

Identities

１. Creation of platform to develop biodigital twin

individualPRIMe will solve this question by developing digital twins of human(biodigital twins) that reproduce in cyber space the biologicalphenomena and pathological processes in human organs to create
Human Metaverse Medicine.

parameters

microscopic data
representing
mechanisms•Quantum sensing•Multi-omics•Imaging

θf•Integrating multiple data modalities•Minimizing black-box elements•Handling noisy and sparse data

2. Creation of Human Metaverse Medicine

PRIMe will elucidate pathogenic mechanisms in human focusing on important life events,i.e., development, reproduction, and aging.

 Elucidation of cause and pathology of 9 diseases associated with eye,liver, brain, heart, and reproductive organs
 Elucidation of metabolic mechanisms through inter‐organ network

3. ELSI study in creation of Human Metaverse Medicine
PRIMe will conduct research and find solutions for ethical, legal, and social issues.

World-class researchers of “human organoid-based biomedical sciences”
and “information and mathematical sciences” will be united, along with quantum
life sciences and ELSI study.
“Biodigital twin” of human individuals will be developed.
Using biodigital twins, Human Metaverse Medicine will be created to elucidate
pathological mechanisms of human diseases (esp. common diseases), to predict
their onset, progression, and treatment response, and to develop their treatment.
Information space platform “human metaverse” will be constructed to sharebiodigital twins with researchers and medical professionals world-wide.
Human Metaverse Medicine will introduce innovation in current medicine torealize ultra-personalized medicine and healthy society.
Next generation human resources specialized in both biomedical science andinformation / mathematical sciences will be fostered.

CollaborationsBiodigital twin
NTT Basic ResearchLaboratories

Tight linkages
around PRIMe

In silico visualization
RIKEN Center for Advanced Photonics

Organoids
Cincinnati Childrenʼs
Hospital Medical CenterInternational
collaboration

Data sciences
Curie Institute
Organoids
Stanford University

Mathematical sciences
University College Dublin