Osamu Ohneda

Faculty of Medicine

E-mail : oohneda@md.tsukuba.ac.jp
Lab web page : http://www.md.tsukuba.ac.jp/stemcell/index.html
Forest of Scholars : https://ura.sec.tsukuba.ac.jp/unit-members?kid=30311872
Kakenhi : 30311872

Orcid : 0000-0002-7717-3802

Affiliation : Laboratory of Regenerative Medicine and Stem Cell Biology, Graduate School of Comprehensive
Human Sciences, University of Tsukuba

Theme●Regenerative Medicine and Stem Cell Biology
Keyword Stem cells, Extracellular vesicles, Hypoxia, Tumor microenvironment

Highlight
Major Scientific Interests of the Group

stem cells and cancers

1) Identification and analysis of functional human5) The roles of human mesenchymal stem cells inadult stem cells for therapycancer development

2) Hypoxic responses in stem cell and tumor

Study Programs for Short Stay Students (onedevelopment

week – one trimester)3) Studying the relation between human adult stem

1) Effects of diseases and aging on human adultcells and cancer cells

stem cells

Projects for Regular Students in Doctoral or2) Human stem cell-derived extracellular vesicles forMaster’s Programs

non-cell therapy

1) Effects of diseases and aging on the functions of3) Interaction between human mesenchymal stem

human adult stem cells

cells and cancer cells2) Functional analysis of human adult stem cell-

Other Faculty Members

derived extracellular vesicles

Assistant Professor, Toshiharu Yamashita

3) Studying the regulation of beige adipogenesis in

Assistant Professor, Vuong Cat Khanhhuman mesenchymal stem cells

Assistant Professor, Mizuho Fukushige4) The roles of hypoxic inducible factors (HIFs) in
Applications and Prospects
Our lab aims to provide a next generation; stem cell-based therapy to the patients. For this purpose,
we study how adult stem cells could function in our body. Our lab has also been elucidating how diseases affect stem cell function.
Now that we understand the problem, we are trying to fix with stem cells using extracellular vesicles. For further read:
https://doi.org/10.21820/23987073.2019.8.51

Literature, intellectualproperty, work
Aqueous Solution for Cell Preservation (Patent No. 8460926/ EP1950283B1)
1.Khanh VC, Yamashita T, Ohneda K, Tokunaga C, Kato H, Osaka M, et al. Rejuvenation of mesenchymal stem cells by
extracellular vesicles inhibits the elevation of reactive oxygen species. Sci Rep. 2020;10(1):17315.
2.Khanh VC, Fukushige M, Moriguchi K, Yamashita T, Osaka M, Hiramatsu Y, et al. Type 2 Diabetes Mellitus Induced
Paracrine Effects on Breast Cancer Metastasis Through Extracellular Vesicles Derived from Human Mesenchymal Stem Cells.
Stem Cells Dev. 2020;29(21):1382.
3.Carolina E, Kato T, Khanh VC, Moriguchi K, Yamashita T, Takeuchi K, et al. Glucocorticoid Impaired the Wound Healing
Ability of Endothelial Progenitor Cells by Reducing the Expression of CXCR4 in the PGE2 Pathway. Front Med (Lausanne).
2018;276(5):1.
4.Kato T, Khanh VC, Sato K, Kimura K, Yamashita T, Sugaya H, Yoshioka T, Mishima H, Ohneda O. Elevated Expression of Dkk-1 by
Glucocorticoid Treatment Impairs Bone Regenerative Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells. Stem Cells Dev.
2018;27(2):85.

https://ura.sec.tsukuba.ac.jp/mori