Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

Wednesday, November 4 (Day 1)
Opening Remarks
8:00-8:10 JST | 18:00-18:10 EST (Nov 3) | 15:00-15:10 PST (Nov 3) | 0:00-0:10 CETEisuke Nishida (Director, RIKEN Center for Biosystems Dynamics Research, Japan)
Keynote Talk 1
Chair: Mitsuru Morimoto
8:10-8:50 JST | 18:10-18:50 EST (Nov 3) | 15:10-15:50 PST (Nov 3) | 0:10-0:50 CET
K1-1* Retinal Organoid TransplantationMasayo Takahashi (RIKEN Center for Biosystems Dynamics Research, Japan /Vision Care Inc., Japan)
Industry Session 1*
8:50-9:00 JST | 18:50-19:00 EST (Nov 3) | 15:50-16:00 PST (Nov 3) | 0:50-1:00 CET
Recorded flash talks from supporting companies and organizations
I1-1
I1-2
I1-3

Foundation for Biomedical Research and Innovation at Kobe
Cyfuse Biomedical K.K.
Sysmex Corporation

Break
9:00-9:20 JST | 19:00-19:20 EST (Nov 3) | 16:00-16:20 PST (Nov 3) | 1:00-1:20 CETSession 1: The Principles of Self-organization 1
Chair: Cantas Alev9:20-9:50 JST | 19:20-19:50 EST (Nov 3) | 16:20-16:50 PST (Nov 3) | 1:20-1:50 CET
S1-1* Mechanism and in vitro reconstitution of mammalian germ-cell development
Mitinori Saitou (Kyoto University, Japan)
9:50-10:20 JST | 19:50-20:20 EST (Nov 3) | 16:50-17:20 PST (Nov 3) | 1:50-2:20 CET
S1-2TBA
Hironobu Fujiwara (RIKEN Center for Biosystems Dynamics Research, Japan)
10:20-10:50 JST | 20:20-20:50 EST (Nov 3) | 17:20-17:50 PST (Nov 3) | 2:20-2:50 CET
S1-3* Organoids by Design: Modeling hepato-pancreato-biliary organogenesis
Takanori Takebe (Center for Stem Cell and Organoid Medicine (CuSTOM),Cincinnati Children’s Hospital Medical Center, USA / Tokyo Medical and DentalUniversity, Japan)*AVAILABLE ON DEMAND

Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

Session 2: The Principles of Self-organization 2
Chair: Hironobu Fujiwara
17:00-17:30 JST | 3:00-3:30 EST | 0:00-0:30 PST | 9:00-9:30 CETS2-1* Genetic Engineering iPS cells for modulating immunogenicity
Akitsu Hotta (Center for iPS Cell Research and Application (CiRA), KyotoUniversity, Japan)
17:30-17:45 JST | 3:30-3:45 EST | 0:30-0:45 PST | 9:30-9:45 CET
S2-2
Generation of nail organ from unipotent nail stem cells expanded in 3D
organoid culture system
Makoto Takeo (RIKEN Center for Biosystems Dynamics Research, Japan)
17:45-18:00 JST | 3:45-4:00 EST | 0:45-1:00 PST | 9:45-10:00 CET
S2-3* Toward Synthetic Embryology and Induced Embryogenesis from Cultured Cells
Cody Kime (RIKEN Center for Biosystems Dynamics Research, Japan)18:00-18:30 JST | 4:00-4:30 EST | 1:00-1:30 PST | 10:00-10:30 CETS2-4
Human Time vs. Mouse Time with Recapitulated Segmentation Clocks
Miki Ebisuya (EMBL Barcelona, Spain)*AVAILABLE ON DEMAND

Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

Thursday, November 5 (Day 2)
Session 3: Memorial Session of Dr. Yoshiki Sasai
Chair: Mitinori Saitou
8:00-8:30 JST | 18:00-18:30 EST (Nov 4) | 15:00-15:30 PST (Nov 4) | 0:00-0:30 CET
S3-1* Development of 3-dimensional telencephalic tissue induction from humanpluripotent stem cells in Sasai lab
Hideya Sakaguchi (RIKEN Center for Biosystems Dynamics Research, Japan)
8:30-9:00 JST | 18:30-19:00 EST (Nov 4) | 15:30-16:00 PST (Nov 4) | 0:30-1:00 CET
S3-2* Dynamic transcriptional control of neural stem cells
Ryoichiro Kageyama (Kyoto University, Japan)
9:00-9:30 JST | 19:00-19:30 EST (Nov 4) | 16:00-16:30 PST (Nov 4) | 1:00-1:30 CET
S3-3* Cell fate trajectories in cortical organoids in development and disease
Flora Vaccarino (Yale University, USA)
Industry Session 2*
9:30-9:45 JST | 19:30-19:45 EST (Nov 4) | 16:30-16:45 PST (Nov 4) | 1:30-1:45 CET
Recorded flash talks from supporting companies and organizations
I2-1
I2-2
I2-3
I2-4

YAMAHA MOTOR CO., LTD.
CELLINK KK
MATRIXOME, Inc.
Nissan Chemical Corporation

Break
9:45-10:00 JST | 19:45-20:00 EST (Nov 4) | 16:45-17:00 PST (Nov 4) | 1:45-2:00 CETSession 4: Engineering Approaches
Chair: Ryuji Yokokawa
10:00-10:30 JST | 20:00-20:30 EST (Nov 4) | 17:00-17:30 PST (Nov 4) | 2:00-2:30 CET
S4-1* Multi-cellular engineered living systems for neurological diseases
Roger D. Kamm (Massachusetts Institute of Technology, USA)
10:30-11:00 JST | 20:30-21:00 EST (Nov 4) | 17:30-18:00 PST (Nov 4) | 2:30-3:00 CET
S4-2* Microfluidics for organoid research
Shoji Takeuchi (The University of Tokyo, Japan)*AVAILABLE ON DEMAND

Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

11:00-11:15 JST | 21:00-21:15 EST (Nov 4) | 18:00-18:15 PST (Nov 4) | 3:00-3:15 CET
S4-3* Transient expression of NFIA enables glial competency and the rapid derivationof astrocytes from human NSCs
Jason Tchieu (Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati
Children’s Hospital Medical Center, USA)
11:15-11:30 JST | 21:15-21:30 EST (Nov 4) | 18:15-18:30 PST (Nov 4) | 3:15-3:30 CET
S4-4* Lighting JeWells: towards an innovative HCS platform for organoids and its
biomedical applications
Anne Beghin (National University of Singapore, Singapore)

Session 5: Cutting Edge Technologies
Chair: Minoru Takasato
17:00-17:30 JST | 3:00-3:30 EST | 0:00-0:30 PST | 9:00-9:30 CET
S5-1
Understanding of gastrointestinal diseases using organoid technology
Toshiro Sato (Keio University School of Medicine, Japan)
17:30-18:00 JST | 3:30-4:00 EST | 0:30-1:00 PST | 9:30-10:00 CET
S5-2* Engineering Organoids-on-a-chip
Matthias P. Lutolf (École Polytechnique Fédérale de Lausanne (EPFL),
Switzerland)
18:00-18:30 JST | 4:00-4:30 EST | 1:00-1:30 PST | 10:00-10:30 CET
S5-3
Lineage recording reveals dynamics of cerebral organoid regionalization
J. Gray Camp (Institute of Molecular and Clinical Ophthalmology Basel,
University of Basel, Switzerland)*AVAILABLE ON DEMAND

Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

Friday, November 6 (Day 3)
Session 6: Modeling Development and Disease 1
Chair: Makoto Takeo
8:00-8:30 JST | 18:00-18:30 EST (Nov 5) | 15:00-15:30 PST (Nov 5) | 0:00-0:30 CET
S6-1* Single cell transcriptomics reveals a signaling roadmap coordinating endoderm
and mesoderm lineage diversification during foregut organogenesis
Aaron M Zorn (Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati
Children’s Hospital Medical Center, USA)
8:30-9:00 JST | 18:30-19:00 EST (Nov 5) | 15:30-16:00 PST (Nov 5) | 0:30-1:00 CET
S6-2* Induction of tracheal mesoderm and chondrocyte from pluripotent stem cells
in mouse and human
Mitsuru Morimoto (RIKEN Center for Biosystems Dynamics Research, Japan)
9:00-9:30 JST | 19:00-19:30 EST (Nov 5) | 16:00-16:30 PST (Nov 5) | 1:00-1:30 CET
S6-3* Lung organoids derived from human pluripotent stem cells
Hans-Willem Snoeck (Columbia Center for Human Development, USA)
Industry Session 3*
9:30-9:40 JST | 19:30-19:40 EST (Nov 5) | 16:30-16:40 PST (Nov 5) | 1:30-1:40 CET
Recorded flash talks from supporting companies and organizations
I3-1
I3-2
I3-3

AGC Inc.
RORZE Lifescience Inc.
Sumitomo Electric Industries Ltd.

Break
9:40-10:00 JST | 19:40-20:00 EST (Nov 5) | 16:40-17:00 PST (Nov 5) | 1:40-2:00 CETSession 7: Modeling Development and Disease 2
Chair: Toshiro Sato
10:00-10:30 JST | 20:00-20:30 EST (Nov 5) | 17:00-17:30 PST (Nov 5) | 2:00-2:30 CET
S7-1
Generating 3-dimensional organs of the urinary tract using human iPS cells
Minoru Takasato (RIKEN Center for Biosystems Dynamics Research, Japan)*AVAILABLE ON DEMAND

Program
JST: Japan Standard Time (Japan) | EST: Eastern Standard Time (US East Coast) | PST: Pacific Standard Time (USWest Coast) | CET: Central European Time (Europe)

10:30-11:00 JST | 20:30-21:00 EST (Nov 5) | 17:30-18:00 PST (Nov 5) | 2:30-3:00 CET
S7-2* Building and repairing human intestine with iPSC generated organoids
Michael A. Helmrath (Center for Stem Cell and Organoid Medicine (CuSTOM),
Cincinnati Children’s Hospital Medical Center, USA)
11:00-11:15 JST | 21:00-21:15 EST (Nov 5) | 18:00-18:15 PST (Nov 5) | 3:00-3:15 CET
S7-3
Towards in vitro human somitogenesis
Cantas Alev (Institute for Advanced Study of Human Biology (ASHBi), Kyoto
University, Japan)
11:15-11:30 JST | 21:15-21:30 EST (Nov 5) | 18:15-18:30 PST (Nov 5) | 3:15-3:30 CET
S7-4* Single-Cell Transcriptomic Analysis Reveals Developmentally Impaired
Endocardial Population in Hypoplastic Left Heart Syndrome
Mingxia Gu (Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati
Children’s Hospital Medical Center, USA)

Keynote Talk 2
Chair: Fumio Matsuzaki
21:00-21:40 JST | 7:00-7:40 EST | 4:00-4:40 PST | 13:00-13:40 CET
K2-1* Modeling human development and disease in cerebral organoids
Juergen A. Knoblich (Institute of Molecular Biotechnology of the Austrian
Academy of Science, Austria)
21:40-22:10 JST | 7:40-8:10 EST | 4:40-5:10 PST | 13:40-14:10 CET
K2-2* Human pluripotent stem cell-derived gastrointestinal organoids as new models
to study human organ development, digestive diseases and diabetes
James Wells (Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati
Children’s Hospital Medical Center, USA)
Closing Remarks
22:10-22:20 JST | 8:10-8:20 EST | 5:10-5:20 PST | 14:10-14:20 CET
Aaron M. Zorn (Director, Center for Stem Cell and Organoid Medicine (CuSTOM),
Cincinnati Children’s Hospital Medical Center, USA)*AVAILABLE ON DEMAND