The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 11 (Mon), Room A (1F)
15:30 - 16:30

Plenary Lecture(50 min Presentation + 10 min Discussion)

Chairperson: Yoshitsugu Shiro (Graduate School of Science, University of Hyogo, Japan)PL

Au nanoparticle-based surface-enhanced Raman imaging reveals
cystathionine-gamma-lyase-derived polysulfide overproduction incancer-associated fibroblasts as a determinant of post-operative
overall prognosis
Makoto Suematsu
Keio University School of Medicine

July 11 (Mon), Room B (2F)
16:30 -

Coffee BreakKanazawa-city, Ishikawa

21

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room A (1F)
8:45 -

Opening Remarks
Yasumitsu Ogra (Chair, ISM-8 Executive Committee/
Graduate School of Pharmaceutical Sciences, Chiba University )9:00 - 11:00

Specialty Session 1 (Keynote Lecture) (25 min Presentation + 5 min Discussion)
Chairpersons: Yoshiaki Furukawa (Department of Chemistry, Keio University, Japan)
Junpei Takano (Department of Agricultural Biology, Graduate School of Agriculture, Osaka
Metropolitan University, Japan)
SS1-1*/KL-1* Regulation of Zinc Homeostasis in Rice
9:00 - 9:30

Luqing Zheng, Shuai Mu, Shubao Hu, Binbin Du
Nanjing Agricultural University(17 min Presentation + 3 min Discussion)
SS1-2
9:30 - 9:50

Boron Transport and Sensing in Arabidopsis
Junpei Takano
Department of Agricultural Biology, Graduate School of Agriculture, Osaka Metropolitan University

SS1-3

9:50 - 10:10

Alterations in renal cadmium distribution and phosphate reabsorption by theadministration of cadmium-metallothionein in mice
Hitomi Fujishiro1, Seiichiro Himeno2
1

SS1-4

10:10 - 10:30

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 2School of Pharmacy, Showa University

ZIP13-iron axis is a new regulatory mechanism for lipolysis
Ayako Fukunaka1, Toru Kimura2, Daisuke Saito1, 3, Toshiyuki Fukada4, Hirotaka Watada3, Yoshio Fujitani1
1

Institute for Molecular & Cellular Regulation, Gunma University, 2Kyorin University School of Medicine, 3Juntendo University Graduate
School of Medicine, 4Tokushima Bunri University

SS1-5

10:30 - 10:50

Sophisticated expression responses of ZNT1 and MT to expression alteration of ZIPs:
Dissecting the mechanism underlying the control of zinc homeostasis
Taiho Kambe
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University

Session Closing
10:50 - 11:00

11:00 -

Coffee Break22

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room A (1F)
11:10 - 11:40

Keynote Lecture 2(25 min Presentation + 5 min Discussion)

Chairpersons: Taiho Kambe (Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Japan)
Lara Massai (Department of Chemistry, University of Florence, Italy)
KL-2

Metal nanoparticle fate in single cell analysis. Consequence andimpact for nanomedicine.
Ivan M. Kempson
Future Industries Institute, University of South Australia

11:40 - 12:16

Oral Session 1 "Cancer"(10 min Presentation + 2 min Discussion)

Chairpersons: Taiho Kambe (Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Japan)
Lara Massai (Department of Chemistry, University of Florence, Italy)
O1-1

11:40 - 11:52

Talc contributes to ovarian carcinogenesis via iron overload through multiple
mechanisms
Yashiro Motooka1, Misako Katabuchi1, 2, Shinya Toyokuni1
1

Department of Pathology and Biological Responses, Nagoya University, 2Department of Obstetrics and Gynecology, Kumamoto
University

O1-2*

11:52 - 12:04

Non-targeted metallomics through synchrotron radiation X-ray fluorescence withmachine learning for cancer screening using blood samples
Yu-Feng Li
Institute of High Energy Physics, Chinese Academy of Sciences

O1-3

12:04 - 12:16

Role of ferroptosis in carcinogenesis and in physiological context
Shinya Toyokuni, Hao Zheng, Yingyi Kong, Yashiro Motooka, Shinya Akatsuka
Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine

12:20 - 13:10

Luncheon Seminar 1
LS-1

Sponsored by: Agilent Technologies, Inc

Life Science Applications and Practical Tips for Metallomic Studies Using Agilent
Triple Quadrupole ICP-MS (ICP-QQQ)
Tetsuo Kubota
Agilent Technologies, Inc

14:30 - 15:50

Specialty Session 2(17 min Presentation + 3 min Discussion)

Chairpersons: Shoji Nakayama (Japan Environment and Children's Study Programme Office, National Institutefor Environmental Studies, Japan)
Yayoi Kobayashi (Health and Environmental Risk Division, National Institute for Environmental Studies, Japan)
SS2-1

14:30 - 14:50

Elemental analysis of biological samples in large-scale birth cohort study
Yayoi Kobayashi, Tomohiko Isobe, Miyuki Iwai-Shimada, Mai Takagi, Shoji F. Nakayama
Health and Environmental Risk Division, National Institute for Environmental Studies

Kanazawa-city, Ishikawa

23

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room A (1F)SS2-2

14:50 - 15:10

Tooth-based biomarkers of atypical metal regulation in Autism Spectrum Disorder
Christine Austin1, Paul Curtin1, Austen Curtin1, Chris Gennings1, Elena Baldwin1, Dani Dumitriu1, 2,
Abraham Reichenberg1, 3, 4, Kristiina Tammimies5, 6, Sven Bölte5, 6, Raymond F. Palmer7, Manish Arora1
1

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 2Departments of Pediatrics
and Psychiatry, Columbia University Irving Medical Center, NY, USA, 3Department of Psychiatry, Icahn School of Medicine at Mount
Sinai, NY, USA., 4Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, NY, USA, 5Center of
Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women’s and Children’s Health, Karolinska Institutet,
Stockholm, Sweden, 6Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Stockholm, Sweden,
7
Family and Community Medicine, School of Medicine, University of Texas Health Sciences Center, TX, USA

SS2-3

15:10 - 15:30

Excessive oral cadmium exposure through rice consumption and renal tubular
dysfunction in farmers in Northern Japan revealed by health examination andhospital-based screening for cadmium nephropathy
Hyogo Horiguchi
Department of Hygiene, Kitasato University School of Medicine

SS2-4*

15:30 - 15:50

Human Biomonitoring in Germany & Europe – science and policy for a healthy future
Aline Murawski, Till Weber, Marike Kolossa-Gehring
German Environment Agency (UBA), Section Toxicology, Health-related Environmental Monitoring

15:50 -

Coffee Break
16:10 - 18:10

Specialty Session 3(25 min Presentation + 5 min Discussion)

Chairpersons: Emiko Harada (Department of Biological Resources Management, School of Environmental
Science, The University of Shiga Prefecture, Japan)
Akiko Hokura (Department of Applied Chemistry, Tokyo Denki University, Japan)
SS3-1

16:10 - 16:40

High-Mg Calcite Nanoparticles Within a Low-Mg Calcite Matrix –a Widespread Strategy in Biomineralization
Boaz Pokroy
Department of Materials Science and Engineering, Technion Israel Institute of Technology

SS3-2

16:40 - 17:10

Organic molecules related to the biomineralization of mollusks and bacteria
Michio Suzuki
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, the Univeristy of Tokyo

SS3-3

17:10 - 17:40

Nanoscale imaging of intact biological specimens in water using scanning electron
assisted dielectric microscopy
Toshihiko Ogura, Tomoko Okada
Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

SS3-4

17:40 - 18:10

Biogenic manganese oxides (BMO) — an introduction to the recent researchdevelopment
Kazuhiro Toyoda1, 2
1Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Japan, 2Graduate School of Environmental Science, Hokkaido
University, Sapporo, Japan

24

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room B (2F)
9:00 - 9:30

Keynote Lecture 3(25 min Presentation + 5 min Discussion)

Chairpersons: Takaaki Itai (Department of Earth and Planetary Science, The University of Tokyo, Japan)
Darryl Neil Johnson (Materials Characterisation and Fabrication Platform, Dept. Chemical
Engineering, The University of Melbourne, Australia)
KL-3*

NEW ADVANCES FOR THE CHARACTERIZATION OF FUNCTIONALIZEDMETALLIC NANOMATERIALS AIMING AT BIOANALYTICALAPPLICATIONS
Jorge Ruiz Encinar, Borja Moreira-Alvarez, Ana Fuentes Cervantes, Jose M Costa Fernandez
Department of Physical and Analytical Chemistry, University of Oviedo

9:30 - 10:42

Oral Session 2 "Analytical Technique-1"(10 min Presentation + 2 min Discussion)
Chairpersons: Takaaki Itai (Department of Earth and Planetary Science, The University of Tokyo, Japan)
Darryl Neil Johnson (Materials Characterisation and Fabrication Platform, Dept. Chemical
Engineering, The University of Melbourne, Australia)
O2-1*
9:30 - 9:42

Investigation of Metal-Protein-Interactions Using a Complementary Analysis Setup
Comprising HPLC-ESI-TIMS-MS and HPLC-ICP-MS
Catharina Erbacher, Philipp Strohmidel, Michael Sperling, Uwe Karst
University of Münster, Institute of Inorganic and Analytical ChemistryO2-2

9:42 - 9:54

Development of a hybrid analytical method for biometals combining elemental
imaging and local speciation
Makiko Iwase, Yasunori Fukumoto, Yu-ki Tanaka, Noriyuki Suzuki, Yasumitsu Ogra
Graduate School of Pharmaceutical Sciences, Chiba University

O2-3

9:54 - 10:06

Stable isotope analysis of mercury-binding proteins in animal samples
Silvia Queipo-Abad1, Warren T. Corns2, David Amouroux1, Zoyne Pedrero-Zayas1
1

Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, Institut des Sciences Analytiques et de Physico-chimie pourl’Environnement et les matériaux, Pau, France, 2PS Analytical, Arthur House, Crayfields Industrial Estate, Main Road, Orpington, Kent BR5
3HP, UK

O2-4

10:06 - 10:18

LA-TOF-ICP-MS – A powerful tool to further examine and elucidate the roll thatmetals play in living systems
Lukas Schlatt, Phil Shaw
Nu Instruments

O2-5

10:18 - 10:30

The imaging of stable Sr isotopes and radioactive 90Sr by using laser ablation ICP-MS/MS
Kayo Yanagisawa1, 2, Makoto Furukawa3, 4, Takafumi Hirata5, Yoshitaka Takagai3, 6
1

Graduate School of Symbiotic Systems Science and Technology, Fukushima University, 2Collaborative Laboratories for Advanced
Decommissioning Science, Japan Atomic Energy Agency, 3Faculty of Symbiotic Systems Science, Fukushima University, 4PerkinElmer
Japan Co., Ltd., 5Geochemical Research Center, Graduate School of Science, the University of Tokyo, 6Institute of Environmental
Radioactivity, Fukushima University

Kanazawa-city, Ishikawa

25

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room B (2F)O2-6

10:30 - 10:42

Hybrid Imaging Analyses of Biomolecules: From Biological Tissues to Molecules andMetalsTadayuki Ogawa1, Eisei Tanaka2, Tomonari Umemura3, Shino Takeda-Homma4, Takafumi Hirata2
1

Research Center for Advanced Medical Science, Dokkyo Medical University, 2Geochemical Research Center, The University of Tokyo,
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 4National Institute of Radiological Sciences, National Institutes
for Quantum Science and Technology

3

10:42 -

Coffee Break
11:00 - 11:30

Keynote Lecture 4(25 min Presentation + 5 min Discussion)

Chairpersons: Yanbei Zhu (National Institute of Advanced Industrial Science and Technology, Japan)
Laurent Ouerdane (IPREM UMR5254 UPPA/CNRS, Pau University, France)
KL-4*

Molybdenum sulfide nanomaterials transform and incorporate into
molybdenum enzymes and affect their activities in vivo
Mingjing Cao, Chunying Chen
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in
Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P. R. China.

11:30 - 12:06

Oral Session 3 "Analytical Technique-2"(10 min Presentation + 2 min Discussion)
Chairpersons: Yanbei Zhu (National Institute of Advanced Industrial Science and Technology, Japan)
Laurent Ouerdane (IPREM UMR5254 UPPA/CNRS, Pau University, France)
O3-1*

11:30 - 11:42

Inductively Coupled Plasma Tandem Mass Spectrometry – versatile tool forinvestigation of superparamagnetic nanoparticles in proteinaceous media
Jacek Maria Sikorski, Agnieszka Kamińska, Magdalena Matczuk, Anna Wróblewska, Lena Ruzik, Maciej Jarosz
Faculty of Chemistry, Warsaw University of Technology

O3-2

11:42 - 11:54

Simultaneous imaging analyses of elements and molecules using laser ablation
coupled with atmospheric pressure plasma-based mass spectrometry
Hui Hsin Khoo1, Haruo Shimada2, Hidekazu Miyahara1, Takafumi Hirata1
1

Geochemical Research Center, School of Science, The University of Tokyo, 2BioChromato, Inc.

O3-3

11:54 - 12:06

Single-cell analysis for measuring intracellular RuBisCO using a cell puncture type
immunosensor
Atsushi Shoji1, Chika Morimoto2, Yukiko Moriiwa1, Kazuhiro Morioka1, Hidetoshi Kumata2, Akio Yanagida1,
Tomonari Umemura2
1

Department of Biomedical analysis, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department of MolecularLife Sciences, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences

26

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room B (2F)
12:20 - 13:10

Luncheon Seminar 2
LS-2

Sponsored by: Japan Laser Corp.

How to Design a Laser Ablation System for Metallomic Bioimaging
Rob Hutchinson1, David Douglas1, Ciaran O’Connor2, Yohei Kamata3, Chihiro Kawada3
1

Elemental Scientific Lasers. 8 Avro Court, Ermine Business Park, Huntingdon, Cambridgeshire, PE29 6XS, United Kingdom. rhutchinson@
icpms.com, 2Elemental Scientific Lasers Inc. 685 Old Buffalo Trail, Bozeman, MT 59715, United States., 3Japan Laser Corp., 2-14-1, NishiWaseda, Shinjuku-ku, Tokyo, 169-0051 Japan

14:30 - 15:00

Keynote Lecture 5(25 min Presentation + 5 min Discussion)

Chairpersons: Shinya Toyokuni (Department of Pathology and Biological Responses, Nagoya University Graduate
School of Medicine, Japan)
Hua Naranmandura (Zhejiang University, China)
KL-5

Molecular magnetic resonance imaging and metallomics
Peter Caravan1, 2, Veronica Clavijo Jordan1, 2, Mariane Le Fur1, 2
1

Institute for Innovation in Imaging, Massachusetts General Hospital, 2Department of Radiology, Harvard
Medical School

15:00 - 16:12

Oral Session 4 "Diagnosis & Therapeutics"(10 min Presentation + 2 min Discussion)
Chairpersons: Shinya Toyokuni (Department of Pathology and Biological Responses, Nagoya University Graduate
School of Medicine, Japan)
Hua Naranmandura (Zhejiang University, China)
O4-1

15:00 - 15:12

Development of heme-selective biomolecule-labeling probes for omics analysis andtissue imaging
Ryo Kakiuchi1, Tasuku Hirayama1, Shohei Tsuji1, Masamitsu Shimazawa1, Tomonori Tamura2, Itaru Hamachi2,
Mieko Tsuji1, Hideko Nagasawa1
1

Gifu Pharmaceutical University, 2Graduate School of Engineering, Kyoto University

O4-2*

15:12 - 15:24

Pharmacokinetics, distribution, and speciation analysis of gadoterate, gadoteridol,
gadobutrol and gadobenate in rats
Mariane Le Fur1, Brianna Moon1, Samantha Zygmont1, Avery Boice1, Iris Zhou1, Nicholas Rotile1,
Pamela Pantazopoulos1, Andrei Astashkin2, Brian Jackson3, Peter Caravan1
1

The Athinoula A. Martinos Center for Biomedical Imaging, The Institute for Innovation in Imaging, Massachusetts General Hospital andHarvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA, 2Department of Chemistry and Biochemistry, University of
Arizona, Tucson, AZ 85721, USA , 3Trace Element Analysis Laboratory, Dartmouth College, Hanover, NH 03755, USA

O4-3*

15:24 - 15:36

Biomineralization-inspired preparation of chitosan/calcium carbonate composite
core-shell microparticles for drug carrier
Satoshi Tanimoto, Izuka Nishii, Shokyoku Kanaoka
Department of Materials Science, The University of Shiga Prefecture

Kanazawa-city, Ishikawa

27

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room B (2F)O4-4

15:36 - 15:48

in vitro ⁄ in vivo activity of fluoromethyl group-introduced antitumor-active dinuclear
platinum(II) complex
Masako Uemura1, Keiichi Hiramoto1, Hiroki Yoneyama2, Yoshihide USAMI2, Shinya Harusawa2, Seiji Komeda1
1Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 2Faculty of Pharmaceutical Sciences, Osaka Medical andPharmaceutical University

O4-5*

15:48 - 16:00

Fine-tuning of multitarget anticancer metallodendrimers cellular incorporation
Andrei Pasca1, 2, Dylan Giffard3, Cristian Pop4, Joaquin Barroso-Flores5, Eugen Gurzau4, Gregory S. Smith3,
Catalin Ioan Vlad1, 2, Bhaskar Saha6, Eva Fischer-Fodor1, Patriciu Achimas-Cadariu1, 2
1

The Oncology Institute “Prof. Dr. Ion Chiricuta”, Cluj Napoca, Romania, 2“Iuliu Hatieganu” University of Medicine and Pharmacy, ClujNapoca Romania, 3University of Cape Town, Cape Town, South Africa, 4Environmental Health Center, Cluj Napoca, Romania, 5National
Autonomous University, Ciudad de México, Mexico, 6National Centre for Cell Science, Ganeshkhind, Pune, India

O4-6

16:00 - 16:12

Tetrazolato-bridged dinuclear Pt(II) complexes and their potential applications incancer chemotherapy
Seiji Komeda, Masako Uemura, Keiichi Hiramoto
Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science

16:12 -

Coffee Break
16:30 - 17:06

Oral Session 5 "Nano Science & Nano Toxicology"(10 min Presentation + 2 min Discussion)
Chairpersons: Yoshinari Suzuki (National Institute of Health Sciences, Japan)
Yu-Feng Li (Institute of High Energy Physics, Chinese Academy of Sciences, China)
O5-1

16:30 - 16:42

Involvement of ER stress response/autophagy in silver nanoparticles exposure-induced cell death in SH-SY5Y cells
Takamitsu Miyayama, Masato Matsuoka
Division of Environmental and Occupational Medicine, Department of Hygiene and Public Health, School of Medicine, Tokyo Women’s
Medical University

O5-2

16:42 - 16:54

Antioxidant supplementation ameliorates the liver steatosis caused by titanium
dioxide nanoparticles
Daisuke Matsumaru1, Yuki Takeshita1, Ryo Koike1, Keishi Ishida1, Yu-ki Tanaka2, Yasumitsu Ogra2,
Tsuyoshi Nakanishi1
1

Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 2Graduate School of Pharmaceutical
Sciences, Chiba University

O5-3*

16:54 - 17:06

The formation of cisplatin targeted delivery systems based on gold nanoparticles– the synthetic and analytical challenges
Anna M. Wróblewska, Jacek Sikorski, Magdalena Matczuk
Chair of Analytical Chemistry, Faculty of Chemistry, Warsaw University of Technology, Poland

O5-4

Withdrawal

17:06 -

Coffee Break28

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 12 (Tue), Room B (2F)
17:20 - 18:20

Oral Session 6 "Health Science"(10 min Presentation + 2 min Discussion)

Chairpersons: Masahiro Kawahara (Department of Bio-Analytical Chemistry, Faculty of Pharmacy, ResearchInstitute of Pharmaceutical Sciences, Musashino University, Japan)
Masato Asanuma (Department of Medical Neurobiology, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences, Japan)
O6-1*

17:20 - 17:32

Metal-coding assisted serological multi-omics study to decipher the pathologicalmechanisms and biomarkers of COVID-19
Ying Zhou1, Shuofeng Yuan2, Hongyan Li1, Kwok-Yung Yuen2, Jasper Fuk-Woo Chan2, Hongzhe Sun1
1

O6-2*

17:32 - 17:44

Department of Chemistry, The university of Hong Kong, 2Department of Microbiology,The university of Hong Kong

Gold(I) complexes: a promising class of SARS-CoV-2 Mpro inhibitors
Lara Massai1, Deborah Grifagni2, Francesca Cantini1, 2, 3, Vito Calderone1, 2, 3, Lucia Banci1, 2, 3, Luigi Messori1
1

Department of Chemistry, University of Florence, via della Lastruccia 3-13, 50019, Sesto Fiorentino, Firenze, Italy, 2Center of Magnetic
Resonance, University of Florence, via Luigi Sacconi 6, 50019, Sesto Fiorentino, Firenze, Italy, 3Consorzio Interuniversitario Risonanze
Magnetiche MetalloProteine (CIRMMP), via Sacconi 6, Sesto Fiorentino, 50019, Italy

O6-3

17:44 - 17:56

Coordination properties of mycobacterial SmtB/BigR4 α5 domain in zinc and nickel
systems; the structure of dimeric BigR4 protein
Sławomir Potocki1, Anna Rola1, Karolina Mojsa2, Anna Pyra1, Damian Trojanowski2, Joanna Hołówka2,
Robert Wieczorek1, Henryk Kozłowski3, Paulina Potok1, Artur Krężel2, Jolanta Zakrzewska-Czerwińska2,Elżbieta Gumienna-Kontecka1
1Faculty of Chemistry, University of Wrocław, 2Faculty of Biotechnology, University of Wrocław, 3Institute of Health Sciences, University of
Opole

O6-4*

17:56 - 18:08

LA-ICP-MS Bioimaging of Metal Ions in the Brain of Parkinson's Disease Model Mouse
Undergoing Manganese-enhanced MRI
Yao Zhao1, Wei Chen2, 3, Fuyi Wang1, 3, Hao Lei2, 3
1

Institute of Chemistry, Chinese Academy of Sciences, 2Innovation Academy for Precision Measurement Science and Technology, Chinese
Academy of Sciences, 3University of Chinese Academy of Sciences

O6-5*

18:08 - 18:20

METALLOMIC – METABOLOMICS APPROACHES TO STUDY THE EFFECT OF METALPOLLUTION ON AGING AND ASSOCIATED NEURODEGENERATIVE PATHOLOGIES
Jose-Luis Gomez-Ariza1, 2
1

Department of Chemistry. Huelva University, 2Research Center on Natural Resources, Health and the Envitonment (RENSMA)

Kanazawa-city, Ishikawa

29

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 13 (Wed), Room A (1F)
8:45 - 9:15

Keynote Lecture 6(25 min Presentation + 5 min Discussion)

Chairpersons: Shigetoshi Aono (Exploratory Research Center on Life and Living Systems, National Institutes of
Natural Sciences, Japan)
Ayako Fukunaka (Institute for Molecular & Cellular Regulation, Gunma University, Japan)
KL-6

Metal complexes in biological environments: a new frontier ininorganic chemistry
Focuses on Mn-SOD mimics: from design to evaluation in cells
Clotilde Policar1, Nicolas Delsuc1, Hélène Bertrand1, Emilie Mathieu1, Gabrielle Schanne1,
Martha Zoumpoulaki1, Hugues Preud’homme2, Ryzsard Lobinski2, Joelle Vinh3,
Giovanni Chiapetta3
1

Laboratoire des biomolécules (LBM), Département de chimie, École normale supérieure, PSL University,
Sorbonne Université, CNRS, 75005 Paris, France , 2IPREM-UMR5254, E2S UPPA, CNRS, Technopôle Helioparc,
64053 Pau Cedex 9 (France), 3SMBP ESPCI Paris, PSL University, UMR 8249 CNRS

9:15 - 10:27

Oral Session 7 "Protein & Enzyme"(10 min Presentation + 2 min Discussion)

Chairpersons: Shigetoshi Aono (Exploratory Research Center on Life and Living Systems, National Institutes of
Natural Sciences, Japan)
Ayako Fukunaka (Institute for Molecular & Cellular Regulation, Gunma University, Japan)
O7-1*
9:15 - 9:27

NtZIP5 in the Zn and Cd homeostasis
Małgorzata Palusińska, Karolina Maślińska-Gromadka, Anna Barabasz, Danuta Maria Antosiewicz
Department of Plant Metal Homeostasis, Faculty of Biology, University of Warsaw, Poland

O7-2

9:27 - 9:39

TEM-1 beta-lactamase is not a metalloenzyme but metal ion binding to the histidinepairs exposed at the protein surface may countZeyad H. A. Nafaee1, 2, Eva Hunyadi-Gulyas 3, Bela Gyurcsik1
1

Department of Inorganic and Analytical Chemistry, University of Szeged, Dom ter 7, H-6720 Szeged, Hungary, 2College of Pharmacy,
University of Babylon, Hillah 51001 Babel, Iraq, 3Laboratory of Proteomics Research, Biological Research Centre, Temesvari krt. 62,
H-6726 Szeged, Hungary

O7-3

9:39 - 9:51

Identification of bacteriostatic agents by inhibiting the iron uptake protein, FbpA,
from a marine-borne Gram-negative bacterium, Vibrio metschnikovii
Peng Lu, Miaomiao Sui, Mimin Zhang, Mengyao Wang, Takehiro Kamiya, Ken Okamoto, Hideaki Itoh,
Suguru Okuda, Michio Suzuki, Tomiko Asakura, Toru Fujiwara, Koji Nagata
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

O7-4

9:51 - 10:03

Structural basis of CO biosynthesis for the assembly of the active site in NiFehydrogenase
Norifumi Muraki, Shigetoshi Aono
Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences

O7-5

10:03 - 10:15

Significance of selenoprotein P expression on selenium-homeostasis in hepatocytes
Moeka Natori , Kotoko Arisawa, Takashi Toyama, Takayuki Hoshi, Yoshiro Saito
Faculty of pharmaceutical sciences, Tohoku University

O7-6

10:15 - 10:27

Bacterial Cu/Zn-superoxide dismutase with a novel foldYoshiaki Furukawa, Shuhei Narikiyo, Masato Akutsu, Atsuko Shintani
Department of Chemistry, Keio University

30

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 13 (Wed), Room A (1F)
10:27 -

Coffee Break
12:00 - 12:50

Luncheon Seminar 3
LS-3

Sponsored by: Thermo Fisher Scientific K.K.

Simultaneous Imagings of Elements and Biomolecules using Mass Spectrometry
coupled with Laser Ablation in Liquid Technique
Takafumi Hirata, Hui Hsin Khoo, Menghao Yang
Geochemical Research Center, The Univ. Tokyo

Kanazawa-city, Ishikawa

31

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 13 (Wed), Room B (2F)
8:45 - 9:15

Keynote Lecture 7(25 min Presentation + 5 min Discussion)

Chairpersons: Michio Suzuki (Department of Applied Biological Chemistry, Graduate School of Agricultural andLife Sciences, the Univeristy of Tokyo, Japan)
Zoyne Pedrero Zayas (CNRS/ IPREM, France)
KL-7

Mercury pollution problem in Russia: current trends and healthoutcomes
Anatoly Skalnyy1, 2, 3
1Sechenov University, 2RUDN University, 3Orenburg State University

9:15 - 10:27

Oral Session 8 "Environmental Science"(10 min Presentation + 2 min Discussion)
Chairpersons: Michio Suzuki (Department of Applied Biological Chemistry, Graduate School of Agricultural andLife Sciences, the Univeristy of Tokyo, Japan)
Zoyne Pedrero Zayas (CNRS/ IPREM, France)
O8-1

9:15 - 9:27

Novel pathway for assimilation of trimethylselenonium in soil microorganisms
Masao Inoue1, 2, Anna Ochi1, Chinatsu Terabe1, Mai Tanaka1, Riku Aono1, Soichi Sato3, Yasumitsu Ogra4,
Hisaaki Mihara1
1

College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University, 3Faculty of Science and Engineering, Toyo University,
Graduate School of Pharmaceutical Sciences, Chiba University

4

O8-2

9:27 - 9:39

Advanced metallophore characterization by hyphenated techniques in the soilmicroorganisms-plants environmental systems
Laurent Ouerdane, Katarzyna Kinska, Alex Goupil, Luluil Maknun, Ryszard Lobinski
Institut des Sciences Analytiques et de Physico-Chimie pour l'Environnement et les Matériaux (IPREM), UMR 5254 CNRS-UPPA-E2S, Pau,
FranceO8-3

9:39 - 9:51

Effect of organics on the stabilization and crystallization of amorphous calcium
carbonate (ACC) in 3D printable pastes
Hadar Shaked1, Iryna Polishchuk1, Alina Nagel2, Yehonadav Bekenstein2, Boaz Pokroy1
1

Bio-Inspired Surface Engineering and Biomineralization Lab, Department of Materials Science and Engineering, Technion - Israel
Institute of Technology, 2Quantum Materials for Energy Applications, Department of Materials Science and Engineering, Technion Israel Institute of Technology

O8-4

9:51 - 10:03

Biosorption mechanism in the selective recovery of precious metals
Ayumi Minoda1, Shin-ichi Miyashita2, Toshihiko Ogura3, Takahiro Kondo4, Yoshio Takahashi51Faculty of Life and Environmental Sciences, University of Tsukuba, 2National Metrology Institute of Japan, National Institute ofAdvanced Industrial Science and Technology , 3Health and Medical Research Institute, National Institute of Advanced Industrial
Science and Technology, 4Faculty of Pure and Applied Sciences, University of Tsukuba, 5Department of Earth and Planetary Science, theUniversity of Tokyo

O8-5

10:03 - 10:15

Learning from intracrystalline proteins in biogenic minerals how to tune various
physical properties of synthetic crystals
Iryna Polishchuk, Nuphar Bianco-Stein, Boaz Pokroy
Technion - Israel Institute of Technology, Department of Materials Science and Engineering

32

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 13 (Wed), Room B (2F)O8-6

10:15 - 10:27

Variation of trace element level in diatom cells from Japanese eutrophic lakes usingsynchrotron radiation microbeam X-ray fluorescence spectrometry
Takaaki Itai, Kazusa Tamura, Yoshio Takahashi
Department of Earth and Planetary Science, The University of Tokyo

10:27 -

Coffee Break
12:00 - 12:50

Luncheon Seminar 4LS-4Sponsored by: PerkinElmer Japan Co., Ltd.

Continuing Evolution of ICP-MS Contributes to Metallomics Research
Kyoko Kobayashi
Application Research Lab / Inorganic, Applied Market, PerkinElmer Japan Co., Ltd.

Kanazawa-city, Ishikawa

33

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 14 (Thu), Room A (1F)
8:45 - 9:15

Keynote Lecture 8(25 min Presentation + 5 min Discussion)

Chairpersons: Yoshiro Saito (Graduate School of Pharmaceutical Sciences, Tohoku University, Japan)
Tejo Prakash Nagaraja (School of Energy and Environment, Thapar Institute of Engineering andTechnology, Patiala, India)
KL-8*

New Strategy for Overcoming ATO-resistant APL
Hua Naranmandura
Zhejiang University

9:15 - 10:15

Oral Session 9 "Metalloid-1"(10 min Presentation + 2 min Discussion)

Chairpersons: Yoshiro Saito (Graduate School of Pharmaceutical Sciences, Tohoku University, Japan)
Tejo Prakash Nagaraja (School of Energy and Environment, Thapar Institute of Engineering andTechnology, Patiala, India)
O9-1

9:15 - 9:27

New insights on mercury detoxification in marine animals: Role of selenoneine andisotopic tracking of HgSe nanoparticles formation
Zoyne Pedrero Zayas1, Khouloud El Hanafi1, Silvia Queipo-Abad1, Laurent Ouerdane1, Claudia MarchánMoreno1, Maite Bueno1, Florence Pannier1, Warren T. Corns2, Yves Cherel3, Paco Bustamante4, 5, David Amouroux1
1

Universite de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, Institut des Sciences Analytiques et de Physico-Chimie pourl’Environnement et les Matériaux, 64000 Pau, France, 2PS Analytical, Orpington, Kent BR5 3HP, U.K., 3Centre d’Etudes Biologiques deChizé, UMR 7372 CNRS−La Rochelle Université, 79360 Villiers-en-Bois, France, 4Littoral Environnement et Sociétés (LIENSs), UMR 7266
CNRS−La Rochelle Université, 17000 La Rochelle, France, 5Institut Universitaire de France (IUF), 75005 Paris, France

O9-2

9:27 - 9:39

Synchrotron μ-XRF imaging of arsenic in frozen-hydrated sections of a root of Pteris
vittata
Teruhiko Kashiwabara1, Nobuyuki Kitajima3, Ryoko Onuma2, Naoki Fukuda2, Satoshi Endo2, Yasuko Terada6,
Tomoko Abe5, Akiko Hokura4, Izumi Nakai2
1

Japan Agency for Marine-Earth Science and Technology, 2Tokyo University of Science, 3Fujita Co., 4Tokyo Denki University, 5RIKEN, 6JASRI
SPring-8

O9-3

9:39 - 9:51

Characterization of pentaheme cytochrome c selenoprotein, a novel polysulfide/
selenite reductase, from Geobacter sulfurreducens
Hisaaki Mihara1, Takuya Yoshizawa1, Yukiko Izu1, Miki Jinno1, Masao Inoue1, 2, Riku Aono1, Ryuta Tobe1,
Hiroyoshi Matsumura1
1

College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University

O9-4*

9:51 - 10:03

Selenium and Seleniferous Crops of Punjab, India: A research account on
quantification, speciation and bioactivity
Tejo Prakash Nagaraja
Centre of Excellence in Emerging Materials, School of Energy and Environment, Thapar Institute of Engineering and Technology, Patiala,
India

34

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 14 (Thu), Room A (1F)O9-5*

10:03 - 10:15

The Role of Selenium on Shaping Mice Brain and Testicular Metabolomes andMetallomes. Microbial-Produced Metabolites and the Crosstalk with Gut Microbiota
Belén Callejón-Leblic1, Sara Ramírez-Acosta1, Marta Selma-Royo2, José Luis Gómez-Ariza1, Nieves Abril3,
MCarmen Collado2, TAMARA GARCÍA-BARRERA1
1

Research Center for Natural Resources, Health and the Environment (RENSMA). Department of Chemistry, Faculty of Experimental
Sciences, University of Huelva, Campus El Carmen, Fuerzas Armadas Ave., 21007, Huelva, Spain, 2Institute of Agrochemistry and Food
Technology (IATA-CSIC), Food Biotechnology, Agustin Escardino 7. 46980 Paterna, Valencia, Spain., 3Department of Biochemistry andMolecular Biology, University of Córdoba, Campus de Rabanales, Edificio Severo Ochoa, E-14071, Córdoba, Spain

10:15 -

Coffee Break
10:30 - 11:18

Oral Session 10 "Metalloid-2"(10 min Presentation + 2 min Discussion)

Chairperson: Hisaaki Mihara (College of Life Sciences, Ritsumeikan University, Japan)
O10-1

10:30 - 10:42

A multi-technique platform for the quantification and identification of Selenoneine
in biological matrices
Claudia Marchan-Moreno1, Christian L. Ward-Deitrich2, Jasmina Allen3, Maite Bueno1, David Amouroux1,
Zoyne Pedrero-Zayas1, Heidi Goenaga-Infante3, Warren T. Corns3
1

Université de Pau et des Pays de l’Adour, E2S UPPA, CNRS, IPREM, Institut des Sciences Analytiques et de Physico-chimie pourl’Environnement et les matériaux, Pau, France., 2LGC Limited, Queens Road, Teddington, Middlesex TW11 0LY, UK, 3PS Analytical, Arthur
House, Crayfields Industrial Estate, Main Road, Orpignton, Kent BR5 3HP, UK

O10-2*
10:42 - 10:54

Chemical Modeling of the Catalytic Cycle of Glutathione Peroxidase Utilizing
Selenocysteine Selenenic Acids Stabilized by a Molecular Cradle
Kei Goto, Ryosuke Masuda, Ryutaro Kimura, Takafumi Karasaki, Shohei Sase, Satoru Kuwano
Department of Chemistry, School of Science, Tokyo Institute of Technology

O10-3

10:54 - 11:06

Detection of peptidyl-prolyl cis-trans isomerase A as a selenotrisulfide reactive
protein in rat brain
Sakura Yoshida1, Akinori Yamamoto1, Tae Kuroiwa1, Miku Hoshikawa1, Hiroshi Masumoto2, Takeshi Fuchigami3,
Akira Toriba1, Morio Nakayama1, Mamoru Haratake4
1

Graduate School of Biomedical Sciences, Nagasaki University, 2Biomedical Research Support Center, School of Medicine, Nagasaki
University, 3Graduate School of Medical Scineces, Kanazawa University, 4Faculty of Pharmaceutical Sciences, Sojo University

O10-4

11:06 - 11:18

A significant role of selenoprotein P as a regulator of pancreatic β cell functiondisorders related to its deficiency and excess
Yoshiro SAITO
Graduate School of Pharmaceutical Sciences, Tohoku University

11:35 -

Closing & Handover Ceremony

Kanazawa-city, Ishikawa

35

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

July 14 (Thu), Room B (2F)
8:45 - 11:30

Specialty Session 4(25 min Presentation + 5 min Discussion)

Chairperson: Kazuya Kikuchi (Graduate School of Engineering, Osaka University, Japan)
SS4-1*
8:45 - 9:15

Single cell ICP-MS to study the uptake of trace elements and the biosynthesis of
nanoparticles by microrganisms
Maria Montes-Bayon1, 2, Roberto Alvarez-Fernández3, Paula García-Cancela1, 2, Beatriz Gómez-Gómez3,
Yolanda Madrid-Albarran3, Jörg Bettmer1, 2
1

Department of Physical and Analytical Chemistry. University of Oviedo, 33006 Oviedo, Spain, 2Instituto de Investigación Sanitaria delPrincipado de Asturias (ISPA), 3Department of Analytical Chemistry, Complutense University of Madrid, 28040 Madrid, Spain

SS4-2*
9:15 - 9:45

Microfluidic chip combined with inductively coupled plasma mass spectrometry forsingle cell analysis
Bin HuDepartment of Chemistry, Wuhan University

SS4-3*
9:45 - 10:15

New tools for illuminating extracellular metallobiology as potential diseasebiomarkers
Marie C Heffern
Department of Chemistry, University of California, Davis

Coffee Break
10:15 - 10:30

SS4-4*

10:30 - 11:00

Metalloproteomics for mapping metals to proteins by in cells: uncovering moleculartarget of chromium(III)
Hongzhe Sun1, Haibo Wang1, Ligang Hu2, Ying Zhou1, Xiaohan Xu1, Guibin Jiang2, Hongyan Li1
1

Department of Chemistry, The University of Hong Kong, Hong Kong, P.R. China, 2State Key Laboratory of Environmental Chemistry and
Ecotoxicology, Research Center for Eco-environmental Sciences, the Chinese Academy of Sciences, Beijing, P.R. China

SS4-5*

11:00 - 11:30

Design of organogold complexes for biomedical applications: from non-covalentinteractions to metal-templated catalysis in cells
Angela Casini
Department of Chemistry, Technical University of Munich

36

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

Poster Presentation July 12 (Tue)- July 14 (Thu), Room C (2F)
On-site Poster Presentation Core Time
Odd Number: 13:20 - 14:20, July 12 (Tue), Room C (2F)
Even Number: 10:50 - 11:50, July 13 (Wed), Room C (2F)
Online Poster Presentation Core Time (oVice)
Odd Number: 20:00 - 20:45, July 12 (Tue), Online (oVice)
Even Number: 20:45 - 21:30, July 12 (Tue), Online (oVice)
P-1

Coupling of Fe stable isotope analysis and X-ray absorption spectroscopy to assess
the biological Fe cycle of marine organisms
Nanako Hasegawa1, Takaaki Itai1, Tatsuya Kunisue2, Yoshio Takahashi1
1Department of Earth and Planetary Science, the University of Tokyo, 2Center for Marine Environmental Studies (CMES), Ehime University

P-2

Withdrawal

P-3

Quantification of trace amount of 90Sr in small size biosamples using isotope
dilution–energy filtered thermal ionization mass-spectrometry: controlling thebackground noise from natural Sr in samples
Jo Aoki1, Shigeyuki Wakaki2, Takashi Miyazaki2, Katsuhiko Suzuki2, Yoshitaka Takagai1, 3
1Faculty of Symbiotic Systems Science, Fukushima University, 2JAMSTEC, 3IER, Fukushima University

P-4

Influence of Alkali Metals on Emission Intensity of Indium and Gallium using Liquid
Electrode Plasma Atomic Emission Spectroscopy (LEP-AES)
Shunto Sakai1, Tamotsu Yamamoto2, Jun Miyazaki3, Akiko Hokura4
1

Department of Materials Science and Engineering, Graduate School of Engineering, Tokyo Denki University, 2Micro Emission Ltd.,
Department of Natural Sciences, School of Engineering, Tokyo Denki University, 4Department of Applied Chemistry, School ofEngineering, Tokyo Denki University3

P-5

Withdrawal

P-6

Development of an Infrared Droplet Desolvation System for Single Human Cell
Introduction to ICP-AES/MS
Takashi Ohta1, Yusaku Yanagii1, Yuya Shimizu1, Kiori Kawade1, Yuki Maemoto2, Motohide Aoki2, Takahiro Iwai3,
Tomonari Umemura2, Koichi Chiba4, Akitoshi Okino1
1

FIRST, Tokyo Institute of Technology, 2School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 3Photon Science Research
Devision, RIKEN, 4School of Science and Technology, Kwansei Gakuin University

P-7

Inverter-modulated microplasma excitation source for high sensitive analysis ofvarious elements
Yuya Shimizu1, Yuta Ishikawa1, Yusaku Yanagii1, Daiki Yoshida1, Takashi Ohta1, Motohide Aoki2,
Tomonari Umemura2, Akitoshi Okino1
1

Laboratory for Future Interdisciplinary Research of Science and Technology, Tokyo Institute of Technology, 2Graduate School of Life
Sciences, Tokyo University of Pharmacy and Life Sciences

P-8

Development of ICP-MS sampling equipment for single cell elemental analysis
Motohide Aoki1, Yanbei Zhu2, Takao Yasui3, Akitoshi Okino4, Tomonari Umemura1
1

School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 2National Metrology Institute of Japan (NMIJ), National
Institute of Advanced Industrial Science and Technology (AIST), 3Department of Biomolecular Engineering, Graduate School ofEngineering, Nagoya University, 4FIRST, Tokyo Institute of Technology

Kanazawa-city, Ishikawa

37

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-9

Development and application of quantitative detection method for reactive
selenium species
Misaki Matsunaga1, Noriyuki Suzuki2, Yasumitsu Ogra2
1

Grad. Sch. Med. Pharm. Sci., Chiba Univ., 2Grad. Sch. Pharm. Sci., Chiba Univ.

P-10

Physiological Response to the Extraordinary Iron Stress in A Unicellular Red Alga
Galdieria sulphuraria
Yukihiro Fukuta1, Shin-ichi Miyashita2, Yuu Hirose3, Ayumi Minoda4
1

Graduate school of science and technology, University of Tsukuba, 2National Metrology Institute of Japan, National Institute ofAdvanced Industrial Science and Technology , 3Faculty of Applied Chemistry and Life ScienceToyohashi University of Technology,
4
Faculty of Life and Environmental sciences, University of Tsukuba

P-11

Polysulfide transport across outer membrane in the sulfur-reducing bacterium
Geobacter sulfurreducens
Daiki Fujita1, Mst. Ishrat Jahan1, Yudai Ishido1, Yukiko Izu1, Masao Inoue1, 2, Riku Aono1, Hisaaki Mihara1
1

Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan , 2Ritsumeikan Global
Innovation Research Organization, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan

P-12

Molecular Dynamics Simulation Reveals Structural Variations of Metallothioneinwith or without Zinc Ions
Rikuri Morita, Yasuteru Shigeta, Ryuhei Harada
Center for Computational Sciences, University of Tsukuba

P-13

Adaptive changes in expression and structure of Ni transporters in the Ni
hyperaccumulator Noccaea japonica
Sho Nishida1, 2, Takuo Enomoto1, Junko Yoshida3, Ryoji Tanikawa4, Takafumi Mizuno3, Naoki Furuta4
1

Faculty of Agriculture, Saga University, 2United Graduate School of Agricultural Sciences, Kagoshima University, 3Graduate School of
Bioresources, Mie University, 4Faculty of Science and Engineering, Chuo University

P-14

Selenite respiration in a Cellulomonas strain isolated from a seleniferous soil
Hibiki Ueda1, Akinori Sakamoto1, Kohei Makimura1, Masao Inoue1, 2, Riku Aono1, Ryuta Tobe1, Yu Hirose3,
N. Tejo Prakash4, Hisaaki Mihara1
1

Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Shiga 525-8577, Japan, 2Ritsumeikan Global Innovation
Research Organization, Ritsumeikan University, Kusatsu, Shiga 525-8577, Japan, 3Department of Applied Chemistry and Biotechnology,
Toyohashi University of Technology, Toyohashi, Aichi 441-8580, Japan, 4Thapar Institute of Engineering & technology, Patiala, Punjab
147004, India

P-15

Different substrate specificities of two catalytic subunits of selenate/tellurate
reductase in Escherichia coli
Kyohei Kusakabe1, Riku Aono1, Masao Inoue1, 2, Ryuta Tobe1, Hisaaki Mihara1
1

College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University

P-16

Functional analysis of a novel molybdenum-dependent methionine sulfoxide
reductase from Bacillus species
Kyohei Kojima1, Yuka Kuzuno1, Anna Ochi1, Riku Aono1, Masao Inoue1, 2, Ryuta Tobe1, Yoichi Takeda1, N. Tejo
Prakash3, Hisaaki Mihara1
1

College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University, 3School of Energy and Environment, Thapar Instituteof Engineering and Technology

P-17

Structure and function of heme uptake system in Corynebacteria
Norifumi Muraki1, 2, Shigetoshi Aono1, 2
1Metallobiology group, Exploratory Research Center on Life and Living System, National Institute for Natural Sciences, 2BiomolecularFunctions, Institute for Molecular Science, National Institute for Natural Sciences

38

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-18

Metallomic investigation for inhibiting the fibril-formation of collagen proteins
Hiroyuki Yasui, Eikichi Tanaka, Hiyori Fukui, Rio Uno, Akari Tsunoda, Wakana Nishino
Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University

P-19

TDP-43 transports ferritin heavy chain mRNA to regulate oxidative stress in neuronalaxons
Jyunki Jinno1, 2, Rehab Abdelhamid1, 2, Yasuyoshi Kimura1, Kensuke Ikenaka1, Goichi Bekku1, Kousuke Baba1, 5,
Yoshitaka Nagai2, 4, Emiko Kasahara3, Atsuo Sekiyama3, Tasuku Hirayama6, Isao Hozumi7, Tatsuya Hasegawa8,
Hideki Mochizuki1, Seiichi Nagano1, 2, 9
1

Department of Neurology, Osaka University Graduate School of Medicine, 2Department of Neurotherapeutics, Osaka University
Graduate School of Medicine, 3Preemptive Medical Pharmacology for Mind and Body, Osaka University Graduate School of
Pharmaceutical Sciences, 4Department of Neurology, Faculty of Medicine, Kindai University Graduate School of Medicine, 5Departmentof Neurology, Faculty of Medicine, Academic Research Division, University of Toyama, 6Laboratory of Pharmaceutical and Medicinal
Chemistry Gifu Pharmaceutical University, 7Laboratory of Medical Therapeutics and Molecular Therapeutics, Gifu Pharmaceutical
University, 8Mount Fuji Research Institute, Yamanashi Prefectural Government, 9Integrated Frontier Research for Medical Science
Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University

P-20

KNS3 and its two homologs form a probable cargo-receptor complex, important for
ER exit of boric acid channels in Arabidopsis
Zhe Zhang1, Arisa Yamasaki1, Shunsuke Nakamura2, Shunsuke Takemura3, Sumie Ishiguro3, Junpei Takano1, 4
1Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 2Graduate School of Agriculture, Hokkaido University,
Graduate School of Bioagricultural Sciences, Nagoya University, 4Graduate School of Agriculture, Osaka Metropolitan University

3

P-21

Regulation of alternative splicing of MYB59 secures shoot K homeostasis under low K
conditions in Arabidopsis thaliana
Takuo Enomoto1, Nobuhiro Tanaka2, Toru Fujiwara3, Sho Nishida1, 4
1Faculty of Agriculture, Saga University, Saga, Japan, 2Institute of Crop Science, NARO, Japan, 3Graduate School of Agricultural and Life
Sciences, The University of Tokyo, Japan, 4United Graduate School of Agricultural Sciences, Kagoshima University, Kagoshima, Japan

P-22*

Helicase (nsp13) as a Target to Develop Inhibitors for Combating SARS-CoV-2
Infection
Xueying WEI, Suyu Wang, Yuen-Ting Wong, Runming Wang, Tianfan Cheng, Lijian Jin, Jasper Fuk-Woo Chan,
Shuofeng Yuan, Hongyan Li, Hongzhe Sun
The University of Hong Kong

P-23

Creation of the Artificial Water Oxidation Metalloenzyme using Cytochrome P450
Scaffold
Misa Kamei, Masaki Nojiri
Department of Chemistry, Graduate School of Science, Osaka University

P-24

Iron(III) and gallium(III) complexes of siderophores and their biomimetic analogues– coordination properties and biological activity in vitro and in vivo
Andrzej Mikołaj Mular1, Isabella Hubmann2, Matthias Misslinger3, Hubertus Haas3, Milos Petrik4,
Clemens Decristoforo2, Elżbieta Gumianna-Kontecka1, Henryk Kozłowski 1
1Faculty of Chemistry Wroclaw University Wroclaw Poland, 2Department of Nuclear Medicine Medical University Innsbruck Austria,
Department of Molecular Biology, Medical University Innsbruck, Innsbruck, Austria, 4Institute of Molecular and Translational Medicine,
Palacký University Olomouc, Olomouc, Czech Republic

3

P-25

Effect of Warm Water Washing of Green Coffee Beans on Elemental Concentrations ofRoasted Coffee Beans Observed by ICP-MS after Microwave Acid Digestion
Yanbei Zhu1, Tomonari Umemura2, Kitaro Oka2
1

National Institute of Advanced Industrial Science and Technology, 2Tokyo University of Pharmacy and Life Sciences

Kanazawa-city, Ishikawa

39

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-26

Histidine rich C-terminal (HRCT) tail of mycobacterial GroEL1 as a potential ligand forCu(II)/Ni(II) ionsAnna Maria Rola, Elżbieta Gumienna-Kontecka, Sławomir Potocki
The Biological Inorganic Chemistry Group, Faculty of Chemistry, University of Wroclaw

P-27

To bind zinc or not to bind zinc: S. pneumoniae metallopeptidase binding site
interaction with Zn(II), Ni(II), and Cu(II)Paulina Potok, Elżbieta Gumienna-Kontecka, Sławomir Potocki
The Biological Inorganic Chemistry Group, Faculty of Chemistry, University of Wroclaw

P-28*

Metallo-sideromycin: A double Trojan Horse strategy for combating antimicrobial
strategy
Chenyuan Wang, Runming Wang, Jingru Li, Patrick H Toy, Hongyan Li, Hongzhe Sun
Department of Chemistry, Faculty of Science, the University of Hong Kong

P-29

Development of a new heme-selective fluorescent probe for sensing subcellular
dynamics of labile heme
Kanta Kawai, Tasuku Hirayama, Takanori Murakami, Masatoshi Inden, Mieko Tsuji, Hideko Nagasawa
Gifu Pharmaceutical University

P-30

Possible involvement of brain copper accumulation in emotional memory
disturbance in multiple mouse models of Down syndrome
Keiichi Ishihara1, Eri Kawashita1, Haruhiko Sago2, Kazuhiro Yamakawa3, Satoshi Akiba1
1

Department of Pathological Biochemistry, Kyoto Pharmaceutical University, 2Center for Maternal -Fetal, Neonatal and Reproductive
Medicine, National Center for Child Health and Development, Tokyo Japan, 3Department of Neurodevelopmental Disorder Genetics,
Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

P-31

Crosstalk of selenium metabolisms between intestinal microflora and a host animal
Kazuaki Takahashi1, 2, Sakie Horiai3, Sayano Iijima3, Yoshikazu Yamagishi4, Hirotaro Iwase4, Yasumitsu Ogra2
1

Graduate School of Horticulture, Chiba University, 2Graduate School of Pharmaceutical Sciences, Chiba University, 3Faculty of
Pharmaceutical Sciences, Chiba University, 4Graduate School of Medicine, Chiba University

P-32

Metallomics Analysis for Early Assessment and Intervention of Neurodevelopment
Disorders: Infantile Zinc Deficiency and Toxic Metal Burdens
Hiroshi Yasuda1, 2, Toyoharu Tsutsui1
1

P-33

La Belle Vie Research Laboratory, 2Institute of Nature and Environmental Technology, Kanazawa University

Neutron irradiation after administration of Gd-EDTMP to a mouse model ofmammary tumor bone metastasis: Effects and distribution of Gd formulation as anovel neutron capture therapy agent
Takehisa Matsukawa1, 2, Minoru Suzuki3, Ayano Kubota1, Atsuko Shinohara1, 4, Kazuhito Yokoyama1, 5
1

Department of Epidemiology and Environmental Health, Juntendo University Faculty of Medicine, 2Department of Forensic Medicine,
Juntendo University Faculty of Medicine, 3Institute for Integrated Radiation and Nuclear Science, Kyoto University, 4Research Institutefor Cultural Studies, Seisen University, 5Department of Epidemiology and Environmental Health, International University of Health andWelfare Graduate School of Public Health

P-34

Dietary exposure to trace elements in Japan in 2019-2021 with time trends since
1977
Yoshinari Suzuki1, Ikuko Kitayama1, Masae Harimoto1, Midori Kondo1, Hiroshi Akiyama1, 2, Tomoaki Tsutsumi1
1National Institute of Health Sciences, 2Hoshi University

P-35

Challenges in measuring minerals in hair as a health indicator
Hiroaki Kitamura, Keigo Sugimoto, Atsuko Ota
Research and Development Department, Aderans Co., Ltd

40

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-36

Vitamin E increases lysosomal Fe (II) production in hepatocytes despite being
protective against ferroptosis
Kotoko Arisawa1, Moeka Natori2, Yoshiro Saito1
1

Graduate School of Pharmaceutical Sciences, Tohoku University, 2Faculty of Pharmaceutical Sciences, Tohoku University

P-37

Iron supplementation attenuates obesity and hepatic steatosis via upregulation of
mitochondrial, heme, and iron-sulfur cluster-associated gene transcription
Naho Kitamura1, 2, Yoko Yokoyama 1, 2, Hiroki Taoka1, 2, Utana Nagano1, 2, Shotaro Hosoda1, 2,
Tanon Taworntawat 1, 2, Anna Nakamura 1, 2, Yoko Ogawa 4, Kazuo Tsubota 2, 4, 5, Mitsuhiro Watanabe 1, 2, 3, 6
1

Graduate School of Media and Governance, Keio University, Japan, 2Health Science Laboratory, Keio Research Institute at SFC, Japan,
Department of Environment and Information Studies, Keio University, Japan, 4Department of Ophthalmology, Keio University Schoolof Medicine, Japan, 5 Tsubota Laboratory, Inc., Japan, 6Department of Internal Medicine, Keio University School of Medicine, Japan

3

P-38

Cu and Zn isotope ratio variations in plasma for survival prediction in haematologicalmalignancy cases
Mari Shimura1, Agustina A. M. B. Hastuti2, Marta Costas-Rodríguez2, Akihiro Matsunaga1, Takayuki Ichinose3,
Shotaro Hagiwara4, Frank Vanhaecke2
1

Research Institute, National Center for Global Health and Medicine, 2Ghent University, Department of Chemistry, Atomic & Mass
Spectrometry – A&MS research unit, 3Inorganic Analysis Laboratories, Toray Research Center Inc., 4Internal Medicine, Hospital, National
Center for Global Health and Medicine

P-39

Development of micromini plasma jet for plasma injection probe to in vivo drug
measurement in living organisms
Daiki Yoshida1, Yuya Shimizu1, Yukiko Moriiwa2, Toshihiro Takamatsu3, 4, Takahiro Iwai5, Atsushi Shoji2,
Akitoshi Okino1
1

FIRST, Tokyo Institute of Technology, 2Tokyo University of Pharmacy and Life Sciences, 3Tokyo University of Science, 4National Cancer
Center Hospital East, 5RIKEN

P-40

Low-temperature Plasma Source Capable of Generating Various Reactive Species andIrradiating Living Organisms
Taiki Osawa1, Zhizhi Liu1, Kai Fukuchi1, Yohei Fukuyama1, Yuriko Matsumura2, Atsuo Iwasawa2, Akitoshi Okino1
1

FIRST, Tokyo Institute of Technology, 2Tokyo Healthcare University

P-41

Development of high-speed temperature control multi-gas plasma jet for irradiating
to living organisms/cells
Toshiki Aizawa1, Yohei Fukuyama1, Yuriko Matsumura2, Atsuo Iwasawa2, Akitoshi Okino1
1

FIRST, Tokyo institute of technology, 2Tokyo Healthcare University

P-42

Estimation of exposure to various elements in infancy via breast milk and formula
milk
Miyuki Iwai-Shimada1, Nozomi Tatsuta2, Kenta Iwai1, Kaname Asato2, Kunihiko Nakai3, Yayoi Kobayashi1,
Mai Takagi1, Shoji F. Nakayama1
1

National Institute for Environmental Studies, 2Tohoku University Graduate School of Medicine, 3Tokai Gakuen University

P-43

Synchrotron radiation-based X-ray absorption spectroscopy revealed production ofMn oxide mediated by epiphytic bacteria in a submerged freshwater macrophyte
Egaria densa
Emiko Harada1, Keisuke Okui2, Sawa Tanaka1, Yumu Azuma1, Tomoki Ichinose3, Kensuke Inaba3, Akiko Hokura3
1

Department of Biological Resources Management, School of Environmental Science, The University of Shiga Prefecture, 2Division ofEnvironmental Dynamics, Graduate School of Environmental Science, The University of Shiga Prefecture, 3Department of Materials
Science and Engineering, Graduate School of Engineering, Tokyo Denki University

Kanazawa-city, Ishikawa

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The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-44

Isolation and characterization of a manganese oxidizing bacterium from asubmerged plant, Ranunculus nipponicus var. submersus
Emiko Harada1, Keisuke Okui2, Hiroshi Hasegawa1, Yoshiyasu Nagakawa3, Takahide Kurosawa4
1

Department of Biological Resources Management, School of Environmental Science, The University of Shiga Prefecture, 2Division ofEnvironmental Dynamics, Graduate School of Environmental Science, The University of Shiga Prefecture, 3Biotechnology Group, Tokyo
Metropolitan Industrial Technology Research Institute, 4Faculty of Symbiotic Systems Science, Fukushima University

P-45

Roles of RecA in growth and round-body formation of Bacillus subtilis exposed toselenite
Anna Ochi1, Masao Inoue1, 2, Riku Aono1, Hisaaki Mihara1
1

College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University

P-46

Crosstalk of zinc and copper in the pathogenesis of vascular type senile dementia
Masahiro Kawahara, Motonari Nakashiro, Risa Ookubo, Ken-ichiro Tanaka, Midori Kato-Negishi
Department of Bio-Analytical Chemistry, Faculty of Pharmacy, Research Institute of Pharmaceutical Sciences, Musashino University

P-47

Tributyltin inhibits neural induction via mitochondrial dysfunction in human iPS cells
Shigeru Yamada, Yukuto Yasuhiko, Yasunari Kanda
Division of Pharmacology, National Institute of Health Sciences

P-48

Biogenic extracellular selenium particles are wrapped within membrane vesicles in
Escherichia coli
Kano Shibamoto1, Anna Ochi1, Yosuke Toyotake1, Riku Aono1, Masao Inoue1, 2, Tomoya Imai3, Hisaaki Mihara1
1

Department of Biotechnology, College of Life Sciences, Ritsumeikan University, 2R-GIRO, Ritsumeikan University, 3Research Institute for
Sustainable Humanosphere, Kyoto University

P-49

Distinct distributions of aluminum, manganese, cobalt, and lead in the Pacific Ocean
Yoshiki Sohrin, Linjie Zheng, Cheuk-Yin Chan
Institute for Chemical Research, Kyoto University

P-50

Arsenic-induced insulin resistance and its relation with muscle loss in humans
Seiichiro Himeno1, Khaled Hossain2
1

P-51

School of Pharmacy, Showa University, 2Rajshahi University

Effect of cadmium on human trophoblast differentiation
Shoko Ogushi1, Tsuyoshi Nakanishi2, Tomoki Kimura1
1

Department of Life Science, Faculty of Science and Engineering, Setsunan University, 2Laboratory of Hygienic Chemistry and Molecular
Toxicology, Gifu Pharmaceutical University

P-52

FOXA1 is responsible factor for cytoprotection by exposure to arsenic in HaCaT cells
Daigo Sumi1, Rio Fujinaga1, Yuri Sato1, Ai Takase1, Seiichiro Himeno1, 2
1

P-53

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 2Faculty of Pharmaceutical Sciences, Showa University

Iron Nanoparticles in plants: toxicity or beneficial effect?
Sandrine CHAY, Lara ZOTTNER, Carine ALCON, Catherine CURIE, Stéphane MARI
Institute for Plant Sciences of Montpellier IPSiM, Metal Mobility team, Cnrs – Inrae – Institut Agro – Université de Montpellier, France

P-54

Formation of biogenic tellurium nanorods in a unicellular green alga,
Chlamydomonas reinhardtii
Shohei Takada1, Yu-ki Tanaka1, Kazuhiro Kumagai2, Keita Kobayashi2, Akiko Hokura3, Yasumitsu Ogra1
1

Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Japan, 2Nanodimensional Standards Group, National
Institute of Advanced Industrial Science and Technology, Japan, 3Department of Applied Chemistry, School of Engineering, Tokyo Denki
University, Japan

42

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-55

Selenium toxicity accelerated by out-of-control response of Nrf2-xCT pathway
Koji Ueda, Akira Aoki, Yoshinori Okamoto, Hideto Jinno
Faculty of Pharmacy, Meijo University

P-56

Distribution of uranium in bone tissues by quantum beam-based elemental analyses
with microbeam
Shino Homma Takeda1, Kyoko Ayama1, Yugo Kato1, Haruko Yakumaru1, Daisuke Ohsawa1, Ryotaro Sato1, 2,
Chiya Numako3, Akihiro Uehara1, Izumi Tanaka1, Masakazu Oikawa1, Oki Sekizawa4, Kiyofumi Nitta4,
Hiroshi Ishihara1
1

National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 2Graduate
School of Science and Engineering, Chiba University, 3Graduate School of Science, Chiba University, 4Japan Synchrotron Radiation
Research InstituteP-57

Conditions for the addition of platinum hyperaccumulation in unicellular algae andspeciation of platinum accumulated in algae
Masato Tokoro1, Kazuhiro Kumagai2, Akiko Hokura1
1
Department of Materials Science and Engineering, Graduate School of Engineering, Tokyo Denki University, 2National Institute ofAdvanced Industrial Science and Technology

P-58

Fundamental study on the detection of uranium in bio-fluids: uranium detection andchemical form in serum
Akihiro Uehara1, Ryotaro Sato1, 2, Daisuke Ohsawa3, Haruko Yakumaru1, Chiya Numako2, Oki Sekizawa4,
Kiyofumi Nitta4, Izumi Tanaka1, Hiroshi Ishihara1, Shino Homma-Takeda1
1

National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, 2Department of Chemistry,
Graduate School of Science, Chiba University, 3Institute for Quantum Medical Science, National Institutes for Quantum Science andTechnology, 4Japan Synchrotron Radiation Research InstituteP-59

Analysis of selenium metabolites accumulated in callus of fern, Athyrium yokoscense
Akiko Hokura1, Koutarou Matsui1, Shota Yuzawa2, Kazuaki Takahashi3, Yasumitsu Ogra3
1

School of Engineering, Tokyo Denki University, 2Graduate School of Science and Engineering, Tokyo Denki University, 3Graduate Schoolof Pharmaceutical Sciences, Chiba University

P-60

Lead increases susceptibility to ferroptosis by disrupting iron and selenium
metabolism
Takayuki Hoshi, Satoru Shiina, Takashi Toyama, Yoshiro Saito
Laboratory of Molecular Biology and Metabolism, Graduate School of Parmaceutical Sciences, Tohoku University

P-61

Thallium induces oxidative stress in hypothalamic neuronal cell line (GT1-7 cells)
Dai Mizuno1, Masahiro Kawahara2, Keiko Mizuno1
1

P-62

Faculty of Medicine, Yamagata University, 2Faculty of Pharmacy, Musashino University

Cadmium induces metallothionein expression in mouse thoracic aorta andperivascular adipose tissue
Yasuyuki Fujiwara, Yayoi Tsuneoka, Tsutomu Takahashi, Yo Shinoda
Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

P-63

Elemental distribution of essential elements in the sternum by micro-PIXE analysis
Yugo Kato, Kyoko Ayama, Haruko Yakumaru, Akihiro uehara, Izumi Tanaka, Masakazu Oikawa,
Shino Homma-Takeda
National Institute of Radiological Science, National Institutes for Quantum Science and Technology

Kanazawa-city, Ishikawa

43

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-64

Induction of a reactive sulfur-producing enzyme cystathionine gamma-lyase incultured vascular endothelial cells exposed to arsenite
Tsutomu Takahashi1, Naoya Miyakawa1, Sumire Fuji1, Yayoi Tsuneoka1, Yo Shinoda1, Tomoya Fujie2, 3,
Chika Yamamoto2, Toshiyuki Kaji3, Yasuyuki Fujiwara1
1

Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Department ofEnvironmental Health, Faculty of Pharmaceutical Sciences, Toho University, 3Department of Environmental Health, Faculty of
Pharmaceutical Sciences, Tokyo University of Science

P-65*

Mechanism of methylmercury toxicity reduction by the transcription factor TCF3
Himeka Ota1, Akari Matsushima1, Takashi Toyama2, Akira Naganuma2, Gi-Wook Hwang1, 2
1

Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University,
Laboratory of Molecular Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University

2

P-66

Tri-substituted organotin compounds bind specifically to lipocalin family protein
complement component 8gamma
Katsuya Yamamoto1, 2, Daisuke Matsumaru1, Keishi Ishida1, Youhei Hiromori1, 3, Satoshi Endo4,
Hisamitsu Nagase1, 5, Tsuyoshi Nakanishi1
1

Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical University, 2JSPS Research Fellow DC, 3Faculty of
Pharmaceutical Sciences, Suzuka University of Medical Science, 4Laboratory of Biochemistry, Gifu Pharmaceutical University, 5Faculty of
Pharmacy, Gifu University of Medical Science

P-67

Construction of ionome database of Japanese wild plants and extraction of plant
nutritional information
Takafumi Mizuno1, Daichi Kondo2, Hiroto Kasai2, Yoshinori Murai3, Atsushi Hashimoto1, Toshihiro Watanabe4
1

Graduate School of Bioresources, Mie University, 2Faculty of Bioresources, Mie University, 3Department of Botany, National Museum of
Nature and Science, 4Research Faculty of Agriculture, Hokkaido University

P-68

Geogenic arsenic and nickel exposure from rice consumption in Yangon Division,
Myanmar: Health risk assessment
Kazuhiro Toyoda1, 2, Aye Myint Myat Soe2, Aye Aye Mu31

Section of Integrated Environmental Science, Faculty of Environmental Earth Science, Hokkaido University, 2Division of Environmental
Science Development, Graduate School of Environmental Science, Hokkaido University, 3Department of Botany, Bago University, Bago,
MyanmarP-69

Development of on-chip sample injection system with a 6-port valve for micro-flowinjection analysis
Kazuhiro Morioka1, Hina Sato1, Kenji Morita1, Akihide Hemmi2, Hizuru Nakajima3, Atsushi Shoji1, Akio Yanagida1
1

Department of Biomedical Analysis, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2Mebius Advanced
Technology Ltd., 3Department of Applied Chemistry, Graduate School of Urban Environmental Sciences, Tokyo Metropolitan University

P-70*

Chrono-toxicity of cisplatin induced renal injury in mice
Hiroki Yoshioka1, Sarah Tominaga2, Masumi Suzui2, Nobuhiko Miura3
1

College of Pharmacy, Gifu University of Medical Science, 2Department of Neurotoxicology, Nagoya City University Graduate School of
Medical Sciences, 3Department of Health Science, Yokohama University of Pharmacy

P-71

Simultaneous quantification of oligo-nucleic acids and ferritin nanocage by sizeexclusion chromatography hyphenated to inductively coupled plasma mass
spectrometry for developing drug delivery systems
Junko Yamazaki, Ippei Inoue, Akihiro Arakawa, Sachise Karakawa, Kazutoshi Takahashi, Akira Nakayama
Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc.

44

The Kanazawa Chamber of Commerce and Industry

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-72

Differentiating nanoparticles based on their composition using continuous, fast, full
spectral acquisitions of a TOF-ICP-MS
Lukas Schlatt, Phil Shaw
Nu Instruments

P-73

Isotopologue pattern based data mining for selenium species from HILIC-ESIOrbitrap-MS derived data
Katarzyna Bierla1, Mihály Dernovics2, Simon Godin1, Márta Ladányi3, Joanna Szpunar1
1

IPREM CNRS UPPA UMR 5254, 2Agricultural Institute, ELRN, 3Institute of Mathematics and Basic Science, MATE

P-74*

MULTI-ELEMENT ANALYSIS OF SINGLE CELLS USING A TOF-ICP-MS – FLOW CYTOMETRY
ANALYSIS ALONG WITH A NOVEL INSTRUMENT CAPABLE OF FAST UNINTERRUPTEDFULL MASS DATA ACQUISITION
Darryl Neil Johnson1, Lukas Schlatt2, Phil Shaw2
1

Materials Characterisation and Fabrication Platform, Dept. Chemical Engineering, The University of Melbourne, 2Nu Instruments,
Clywedog Road South Wrexham Industrial Estate, Wrexham, UK

P-75*

Analysis of metal-binding mechanism in SOD1 by native mass spectrometry
Satoko Akashi1, Michiko Tajiri1, Yoshiaki Furukawa2
1

Graduate School of Medical Life Science, Yokohama City University, 2Department of Chemistry, Keio University

P-76*

Using CO2 Reaction to Achieve Mass-Spectrometric Discrimination for Pu isotopic
analysis with Inductively Coupled Plasma-Mass Spectrometry
Makoto Matsueda1, 2, Tomohiko Kawakami3, Kazuma Koarai2, Motoki Terashima2, Kenso Fujiwara2, Kazuki Iijima2,
Makoto Furukawa4, Yoshitaka Takagai1, 5
1Faculty of Symbiotic Systems Science, Cluster of Science and Technology, Fukushima University, 2Collaborative Laboratories for
Advanced Decommissioning Science, Japan Atomic Energy Agency, 3Kaken Inc., 4PerkinElmer Japan Co., Ltd., 5Institute of Environmental
Radioactivity, Fukushima University

P-77*

Identification of a Transcription Factor, SPL7, Involved in the Enhanced Expression of
SULTR2;1 in Arabidopsis Roots
Tsukasa Ushiwatari 1, Akiko Maruyama-Nakashita1, Nobutaka Mitsuda2, Toshiharu Shikanai3
1

Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 2Bioproduction Research Institute, National
Institute of Advanced Industrial Science and Technology (AIST), 3Department of Botany, Graduate School of Science, Kyoto University

P-78*

Pharmacological role of metallothionein in drug-induced gingival overgrowth
Yukihiko Tamura1, Pornpoj Fuangtharnthip2, Yasuka Kusumoto3, Tsutomu Iwamoto3, Yoshihiro Waki4
1

Department of Dental Pharmacology, Division of Bio-Matrix, Graduate School of Medical and Dental Sciences, Tokyo Medical and
Dental University, Tokyo Japan, 2Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok,
Thailand, 3Department of Pediatric Dentistry/Special Needs Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical
and Dental University, Tokyo Japan, 4Division of Social Pharmacy, Department of Pharmaceutical Sciences, Nihon Pharmaceutical
University, Saitama, Japan

P-79*

Semistable and redox active kinetic intermediates expose a gold mine of novel ideas
for copper biology
Radosław Kotuniak1, Iwona Ufnalska1, Marc J.F. Strampraad2, Peter-Leon Hagedoorn2, Wojciech Bal1
1

Laboratory of Biological Chemistry of Metal Ions, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Poland,
Department of Biotechnology, Delft University of Technology, The Netherlands

2

P-80*

Bactericidal and Anti-oxidant Activity of SeNPs Concomitantly Synthesized andStabilized with Fungal Extracts
Anmol1, Ranjana Prakash2, Sumit Jaiswal3, Hisaaki Mihara4, Tejo Prakash Nagaraja5
1

School of Chemistry and Biochemistry, Thapar Institute of Engineering and Technology, 2School of Chemistry and Biochemistry, Thapar
Institute of Engineering and Technology, Patiala, India, 3Department of Microbiology, Marwadi University, Rajkot, India, 4Departmentof Biotechnology, Ritsumeikan University, Kusatsu, Japan, 5School of Energy and Environment, Thapar Institute of Engineering andTechnology, Patiala, India

Kanazawa-city, Ishikawa

45

The 8th International Symposium on Metallomics
July 11, 2022 (Mon) – July 14, 2022 (Thu)*: Online presentation

P-81*

Effect of metallothionein on elastase-induced pulmonary emphysema
Ken-ichiro Tanaka1, Sachie Shiota1, Okina Sakakibara1, Mikako Shimoda1, Ayaka Takafuji1, Misaki Takabatake1,
Yoshito Kadota2, Takashige Kawakami2, Shinya Suzuki2, Masahiro Kawahara1
1

Laboratory of Bio-Analytical Chemistry, Faculty of Pharmacy, Musashino University, 2Faculty of Pharmaceutical Sciences, Tokushima
Bunri University

P-82

Withdrawal

P-83*

Targeting zinc-binding protein metallothionein in astrocytes for dopaminergic
neuroprotection
Ikuko Miyazaki, Masato Asanuma
Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

P-84*

Marine environmental impact assessment technique for ecological effects of heavy
metals using amphipod
Kyoko Yamaoka1, Akira Iguchi1, Miyuki Nishijima1, Eri Ikeuchi1, Yukiko Kozaka1, Atsushi Suzuki1, Masayuki Nagao1,
Misa Toda2, Tetsuro Okamura2
1

Geological Survey of Japan, AIST, 2IDEA Consultants, Inc.

P-85*

Tributyltin decreases lysosomal acidity and inhibits autophagic degradation
Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake
Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.

P-86*

Variations of anthropogenic Gadolinium, Lanthanum, and presence of iodine inwastewater from water-recycle plants in Sapporo city, Hokkaido, Japan
Zakia Aktar1, Kazuhiro Toyoda1, 2
1

Graduate School of Environmental Science, Hokkaido University, 2Faculty of Environmental Earth Science, Hokkaido University

46

The Kanazawa Chamber of Commerce and Industry