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KOD -Multi & Epi-TM
First issue : Dec. 9, 2014

SDS No. 973F

Safety Data Sheet

1 PRODUCT AND COMPANY IDENTIFICATION
Product Name
Product Code
SUPPLIER
Name
AddressDepartment
Emergency Telephone No.

Fax No.
Recommended use andrestrictions on use

KOD -Multi & Epi-TM
KME-101TOYOBO Co., Ltd.
2-2-8 Dojima Hama Kita-ku Osaka, 530-8230 Japan
Biotech support Department+81-6-6348-3786+81-6-6348-3833
PCR kit for DNA amplification(Reagent for research)

2 HAZARDS IDENTIFICATION
Most Important Hazards
Few adverse human health effects are anticipated.
Specific Hazards
Classification not possible
GHS Classification
Hazard class and category
Physical Hazards
Not Applicable
Health Hazards
Acute toxicity - oral
Skin corrosion/Irritation
Serious eye damage/Eyeirritation
Environmental Hazards

KOD -Multi & Epi-TM
Classification not possible
Category 3
Category 2B

2x PCR Buffer for KOD -Multi & Epi-TM
Category 5
Category 3
Classification not possible

Not ApplicableLabel elements
TM<KOD -Multi & Epi- >Pictograms or symbols
Signal word

Warning
Causes mild skin irritation.
Hazard statements
Causes eye irritation.
Precautionary statement(s)Prevention
Response

If skin irritation occurs: Get medical advice / attention. If in eyes: Rinse cautiously with water forseveral minutes. Remove contact lenses, if present and easy to do. Continue rinsing.If eye irritation
persists: Get medical advice / attention.
TM<2x PCR Buffer for KOD -Multi & Epi- >Pictograms or symbols
Signal word
Warning
May be harmful if swallowed.
Hazard statements
Causes mild skin irritation.
Precautionary statement(s)Prevention
Response

Call a POISON CENTER or doctor / physician if you feel unwell.
If skin irritation occurs: Get medical advice / attention.

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KOD -Multi & Epi-TM
First issue : Dec. 9, 2014

SDS No. 973F

Safety Data Sheet
3 COMPOSITION / INFORMATION ON INGREDIENTS
Chemical Product(Substance/Preparation)
Chemical Nature
Parts Name

MixtureAqueous solution of enzyme, substrate, etc.
CAS No. (EC NO.)
Main components
DNA polymerase(EC 2.7.7.7)
KOD -Multi & Epi-TM
monoclonal antibody
56-81-5GlycerolPoly(oxyethylene)
9016-45-9
Nonylphenylether
2× PCR Buffer for KOD - Tris(Hydroxymethyl)aminomethane 77-86-1
Multi & Epi-TM
Magnesium sulfate
7487-88-9
Deoxyadenosine triphosphate
1927-31-7
Deoxycytidine triphosphate
102783-51-7
Deoxyguanosine triphosphate
93919-41-6
Deoxythymidine triphosphate
18423-43-3
Additive
Nondisclosure
Components Contributing to the Hazard
Common Chemical Name
Poly(oxyethylene)
Glycerol(or Generic Name)
Nonylphenylether
Nonidet P-40
Synonyms
Glycerin
Contained
KOD -Multi & Epi-TM ：50%
KOD -Multi & Epi-TM ：0.05%
Parts:Percentage
HO(C2H4O)n-C6H4-C9H19
Chemical formula
CH2OHCHOHCH2OH
CAS No.
56-81-59016-45-9
Concentration
0.05%
50%

Additive
Nondisclosure
2×PCR Buffer for KOD -Multi& Epi-TM ：<3%
Nondisclosure
Nondisclosure<3%4 FIRST-AID MEASURESInhalation

Remove person to fresh air. Call a doctor if you feel unwell.

Skin Contact
Eye Contact

Wash with clean water, immediately.
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsin
If eye irritation persists: Get medical advice / attention.
If swallowed: Rinse mouth. Do NOT induce vomiting.
If indisposition continues, seek medical attention.

Ingestion

5 FIRE-FIGHTING MEASURESExtinguishing Media
Protection of fire-fighters

Water, Carbon Dioxide, Foam, Dry Chemical Powder
Fire-fighting should be done from the windward side of fire area. Fire-fighters should wear proper
protective equipment in case of large scale fire.

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KOD -Multi & Epi-TM
First issue : Dec. 9, 2014

SDS No. 973F

6 ACCIDENTAL RELEASE MEASURES
Personal Precautions
Environmental Precautions
Methods for Cleaning up

Safety Data Sheet

Wear protective gear to avoid eye/skin contact and inhalation.
Avoid disposition to the environment.
Use cloth, paper or anything similar to soak up the solution leaking out of the container. Take up undervacuum using dust collecting filter.

7 HANDLING AND STORAGE
HANDLING
Technical Measures
Precautions
Safe Handling Advice
STORAGETechnical Measures
Storage Conditions
Incompatible Products
Packaging Materials

Wear protective equipments and avoid contact with eyes and skin. Handle with ventilation and local
exhaust system.
Avoid substance contact .After handling, wash with clean water.
Always keeping things tidy and in order, and keep laboratory Clean..
Store in the laboratory bottle
Store at about -20°C
Oxidizers
Store in the original package.

8 EXPOSURE CONTROLS/ PERSONAL PROTECTION
ENGINEERING MEASURES Set up good ventilation and exhaust system in the work area.

Control Parameter
Limit Values
JSOH OELACGIH TLVOSHA PEL

GlycerolNot established
10mg/m3
total dust:15mg/m3TWA
respirable fr.: 5mg/m3TWA

Poly(oxyethylene)
Nonylphenylether

Additive

Not establishedNot establishedNot establishedNot establishedNot establishedNot establishedPERSONAL PROTECTIVE EQUIPMENT

Respiratory Protection
Hand Protection
Eye ProtectionSkin and Body Protection

Wear a dust mask.
Chemical safety gloves.
Chemical safety goggles.
Long sleeves to prevent contact with skin.

9 PHYSICAL AND CHEMICAL PROPERTIES
Physical StateColourOdour
pHFlash Point
Boiling Point
Melting Point
Decomposition TemperatureSpecific Gravity
Solubility

KOD -Multi & Epi-TM and 2x PCR Buffer for KOD -Multi & Epi-TM are liquid over -20°C
None
None
7.0-9.0
No flammability due to aqueous solution, but glycerol whose flash point 160°C may stay behind after
volatilization KOD -Multi & Epi-TM.
Classification not possible
Classification not possibleClassification not possible
1.0-1.2
Soluble in water

10 STABILITY AND REACTIVITY
Stability

Stable at -20°C

Possible Hazardous Reactions NoneConditions to Avoid
Material to Avoid
Hazardous Decomposition
ProductStrong heat and Direct sunlightstrong oxidizers and strong reducers
Classification not possible

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KOD -Multi & Epi-TM
First issue : Dec. 9, 2014

SDS No. 973F

Safety Data Sheet
11 TOXICOLOGICAL INFORMATION<KOD -Multi & Epi-TM>
Classification not possible
Acute Toxicity
May cause eye and skin irritation. May cause respiratory tract irritation.
Local EffectsToxicological information on the component of this product
Poly(oxyethylene)
GlycerolNonylphenylether
Acute toxicity (LD50)
Oral-mouse: 4090mg/kg
Oral-mouse: 3500mg/kg
Oral-rat: 12.6g/kg
Oral-rat: 4190mg/kg
Category 3
Category 3
Skin corrosion/Irritation
Serious eye damage/Eye
Category 2B
Category 2Airritation<2x PCR Buffer for KOD -Multi & Epi-TM>
Acute Toxicity
Classification not possible
Local Effects
May cause eye and skin irritation. May cause respiratory tract irritation.
Toxicological information on the component of this product
Additive
Acute toxicity (LD50)Oral-rat: 50mg/kg*
Category 2
Skin corrosion/Irritation
Serious eye damage/EyeCategory 3
irritation*Acute toxicity (LD50) of Additive is estimated from similar agent.

12 ECOLOGICAL INFORMATION
Mobility
Persistence/Degradability
Bioaccumulation

Soluble in water and diffusible into water environment.
Classification not possible
Classification not possible

13 DISPOSAL CONSIDERATIONS
Waste from Residues

Dispose of in accordance with all applicable local and national laws and regulations.

Contaminated Packaging

Dispose of in accordance with all applicable local and national laws and regulations.

14 TRANSPORT INFORMATIONInternational Regulations
UN Classification Number

Specific Precautions

Not classified
Follow all of the laws and regulations in your respective country.
To prevent packages from breaking, handle with care. Store at about -20°C when it is transported.

15 REGULATORY INFORMATION
Follow all of the laws and regulations in your country.

16 OTHER INFORMATION
NoticeThis product is sold for research purposes only and is not required to appear on the TSCA inventory. It is
not intended for food, drug, household, agricultural or cosmetic use. Its use must be supervised by atechnically qualified individual experienced in handling potentially hazardous chemicals. The informationin this SDS, to the best of our knowledge, is accurate and correct. However, TOYOBO makes no warranty
and assumes no liability whatsoever in connection with any use of this information. The information shallnot be taken as being all inclusive and is to be used only a guide. All materials and mixtures may bepresent unknown hazards and should be used with caution. The SDS is subject to revision as new
information becomes available.