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MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:
SDS No.1407F

Safety Data Sheet
1 Chemical product and company identification
Identification of the productProduct Code
SUPPLIERNameAddress
Department
Emergency Telephone No.
Fax No.
Recommended uses and restrictions on use

MagExtractorTM -GenomeNPK-101,102,192,101S
TOYOBO Co., Ltd.
2-2-8 Dojima Hama Kita-ku Osaka, 530-8230 Japan
Biotech support Department+81-6-6348-3786+81-6-6348-3833
Isolation of genomic DNA
This product is sold for research purposes only . It is not intended for food,drug, household, agricultural or cosmetic use.

2 Hazards identification
Important hazards
Physical and chemical hazards
Adverse effects on human healthAdverse effects on the environment
GHS classification

Guanidinium hydrochloride is contained in Lysis&Binding Solution andWashing Solution. May cause eye and skin irritation.
May develop poisonous gas in contact with oxidant.

Hazard class and category<Magnetic beads>

Physical Hazards

Classification notpossible

Health Hazards
Acute toxicity: Oral
Skin corrosion/Irritation
Serious eye damage/Eye irritation
Carcinogenicity
Specific target organ toxicity (singleexposure)Specific target organ toxicity (repeatedexposure)Environmental Hazards

Not classified
Classification notpossible
Category 2
Classification notpossible
Category 3(respiratory tractirritation)
Category 1(respiratoryorgans)Classification notpossible<Lysis&BindingSolution>
Classification notpossible<Washing Solution>
Classification notpossible

Category 4

Category 4

Category 2

Category 2

Category 2
Classification notpossible

Category 2
Classification notpossibleClassification notpossibleClassification notpossibleClassification notpossibleClassification notpossibleClassification notpossibleClassification notpossible2 / 6 ページ

MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:SDS No.1407F

Safety Data Sheet
2 Hazards identification(Continued)
Label elements<Magnetic beads>
Pictograms or symbols
Signal word
Hazard statements

Danger
Causes serious eye irritation
May cause respiratory irritation
Cause damage to respiratory organs through prolonged or repeated exposure

Precautionary statements
Prevention

Response

Wear eye protection / face protection. Wash hands thoroughly after handling.
Do not breathe dust / fume / gas / mist / vapours /spray. Use only outdoors orin a well-ventilated area.
Do not eat, drink or smoke when using this product.
If in eyes: Rinse cautiously with water for several minutes. Remove contactlenses, if present and easy to do. Continue rinsing. If eye irritation persists:
Get medical advice / attention.
If inhaled: Remove person to fresh air and keep comfortable for breathing.
Get medical advice/attentions if you feel unwell.

Store locked up.
Store in a well-ventilated place. Keep container tightly closed.
Dispose of contents / container in accordance with local / regional / National
Disposal/international regulation.
<Lysis&Binding Solution>, <Washing Solution>
Pictograms or symbols
Storage

Signal words
Hazard statements

Precautionary statements
Prevention

Response

Disposal

Warning
Harmful if swallowed
Cause skin irritation
Causes serious eye irritation
Wash hands thoroughly after handlingDo not eat, drink or smoke when using this product.
Wear protective gloves/eye protection/face protection.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if youfell unwell. Rinse mouth.
IF ON SKIN: Wash with plenty of water and soap.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses if present and easy to do. continue rinsing.
If eye irritation persists: Get medical advice/attention.
Dispose of contents / container in accordance with local / regional / National/international regulation.

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MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:SDS No.1407F

Safety Data Sheet
3 Composition/information on ingredients
Chemical product (a substance or a mixture)

Chemical Nature
Parts Name
<Magnetic Beads><Lysis & Binding Solution><Washing Solution>
Components Contributing to the Hazard
Common Chemical Name(or Generic Name)

Mixture<Lysis & Binding Solution>, <Washing Solution>; aqueous solution<Magnetic Beads>; aqueous dispersion
Main components
Magnetic Beads (Silicon dioxide, triiron tetraoxide)
Sodium Chloride
Guanidine Hydrochloride
di-Sodium Dihydrogen Ethylenediaminetetraacetate
Dihydrate
Polyoxyethylene Sorbitan Monolaurate
Guanidine Hydrochloride
Silicon dioxide

triiron tetraoxide

Synonyms

colloidal silica

iron(II) iron(III) oxide

Contained Parts:Percentage

Magnetic Beads:
15～30%

Magnetic Beads:
5～15%

7631-86-9

1317-61-9

CAS No.

CAS No. (EC No.)7647-14-5
50-01-1
6381-92-6
9005-64-5
50-01-1
Guanidine Hydrochloride
Guanidinium
Hydrochloride
Lysis&Binding Solution
Washing Solution
45～65%
50-01-1

4 First-aid measures
Inhalation
Skin contact

Eye contact

Ingestion
Most important symptoms/effects

In case of irritation by inhaling this product, move affected person to fresh air.
Call a POISON CENTER or doctor if you feel unwell.
Take off immediately all contaminated clothing. Wash with plenty of cleanwater, immediately. If skin irritation occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice / attention.
Rinse mouth. Call a POISON CENTER or doctor/physician if you fell unwell.
Do not induce to vomiting.
Inhalation, Ingestion: Cough, Diarrhea
Skin, Eye: Pain, Redness

5 Fire-fighting measures
Extinguishing media
Specific hazards
Precautions for fire-fighters

Powder, Carbon Dioxide, Foam, Dry sandToxic gas containing carbon monoxide, nitrogen oxides, chlorine/hydrogenchloride may be generated upon combustion of.
Fire-fighting should be done from the windward side of fire area. Fire-fightersshould wear proper protective equipment in case of large scale fire.

6 Accidental release measures
Personal precautions
Environmental precautions
Methods for cleaning up

Wear protective gear to avoid eye/skin contact and inhalation.
Avoid disposition to the environment.
Use cloth, paper or anything similar to soak up the solution leaking out of thecontainer. Take up under vacuum using dust collecting filter.

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MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:
SDS No.1407F

Safety Data Sheet
7 Handling and storage
Handling
Technical measures
Precautions
Hygene measures

Wear protective equipment and avoid contact with eyes and skin.
Handle the reagent not to generate aerosol or dust.
Use only in a well-ventilated area.
Do not eat, drink or smoke when using this product. Wash hands thoroughly
after handling.

StorageTechnical measures
Packaging Materials

Keep tightly closed and store at about 2-8℃.
Store in a well-ventilated area.
Store in the original package

8 Exposure controls and personal protection
Engineering controls
Personal protective equipment
Respiratory protection
Hand protection
Eye protection
Skin and body protection

Set up good ventilation and exhaust system in the work area. Provide showerand eye washing apparatus nearby.
Wear a dust mask.
Chemical safety gloves.
Chemical safety goggles.
Wear lab coat when needed.

9 Physical and chemical properties
Physical State
ColourpH
Flash point
Explosion limit
Density
Solubility

LiquidBrown suspension(Magnetic Beads), Clear solution(Others)
7.0～8.0
No flammability due to aqueous solution
Not explosive
Not available
Soluble in water except for Magnetic Beads .

10 Stability and reactivity
Chemical stability and hazardous reactions
Conditions to Avoid
Incompatible materials
Hazardous decomposition products

Stable under normal handling.
Strong oxidizers
carbon monoxide, nitrogen oxides, chlorine, hydrogen chloride5 / 6 ページ

MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:
SDS No.1407F

Safety Data Sheet
11 Toxicological information
Acute toxicity
May be harmful if swallowed
Skin irritation/corrosion
May cause eye and skin irritation.
Specific target organ toxicity-single exposure
May cause respiratory irritation.
Toxicological information on the component of this product
Silicon dioxide

Triiron tetraoxide

Guanidine Hydrochloride

Not available

Not classified

Rat: LD50
774mg/kg

Dermal toxicity

Not available

Not classified

Inhalation toxicity

Not available

Not available

Not available
Not available
IARC Group 3
Category 3(respiratory tractirritation)
Category 1(respiratoryorgans)

Not classified
Category 2
Not available

Acute toxicity
Oral toxicity

Skin corrosion/Irritation
Eye damage/irritation
Carcinogenicity
Specific target organ toxicity-single exposure

Specific target organ toxicity-repeatedexposure

Rabbit: LD0 >2000mg/kg
Rat: LC50
5.319mg/L
Category 2
Category 2A
Not available
Not available

Not available
Not available
Not available

12 Ecological information
Ecotoxicity
Persistence and degradability
Bioaccumulative potential
Mobility in soil

Not available
Not available
Not available
Soluble in water and diffusible into water environment except for Magnetic
Beads.

13 Disposal considerations
Waste from residues
Contaminated container and Contaminatedpackaging

Dispose of in accordance with all applicable local and national laws andregulations.
Dispose of in accordance with all applicable local and national laws andregulations.

14 Transport information
International Regulations
UN numberSpecific Precautions

Not classified
Follow all of the laws and regulations in your respective country.
To prevent packages from breaking, handle with care.

15 REGULATORY INFORMATION
Follow all of the laws and regulations in your country.

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MagExtractorTM -GenomeFirst issue: Mar 21, 2017
Revised issue:
SDS No.1407F

Safety Data Sheet
16 OTHER INFORMATION
NoticeIt is not intended for food, drug, household, agricultural or cosmetic use. Its use
must be supervised by a technically qualified individual experienced inhandling potentially hazardous chemicals. The information in this SDS, to thebest of our knowledge, is accurate and correct. However, TOYOBO makes nowarranty and assumes no liability whatsoever in connection with any use of thisinformation. The information shall not be taken as being all inclusive and is tobe used only a guide. All materials and mixtures may be present unknown
hazards and should be used with caution. The SDS is subject to revision as new
information becomes available.