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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
1 Chemical product and company identification
Identification of the productProduct Code
SUPPLIERNameAddress
Department
Emergency Telephone No.
Fax No.
Recommended uses and restrictions on use

MagExtractorTM -RNANPK-201F, NPK-292F
TOYOBO Co., Ltd.
2-2-8 Dojima Hama Kita-ku Osaka, 530-8230 Japan
Biotech support Department+81-6-6348-3786+81-6-6348-3833
Isolation of RNA (for research use only)

2 Hazards identification
Important hazards
Physical and chemical hazards
Adverse effects on human healthAdverse effects on the environment
GHS classification

Guanidinium hydrochloride is contained in Lysis&Binding Solution andWashing Solution. May cause eye and skin irritation.
May develop poisonous gas in contact with oxidant.

Hazard class and category<Magnetic beads>

Physical Hazards

Classification notpossible<Lysis&BindingSolution>
Classification notpossible

Not classified

Category 4

Category 4

Category 2

Category 2

Category 2

Category 2AClassification notpossible

Category 2AClassification notpossible

Category 2

Category 2

Category 2AClassification notpossibleClassification notpossible

Health Hazards
Acute toxicity: Oral
Skin corrosion/Irritation
Serious eye damage/Eye irritation
Carcinogenicity
Toxic to reproduction

Specific target organ toxicity (singleexposure)Specific target organ toxicity (repeatedexposure)Environmental Hazards
Acute hazards to the aquatic environmentLong-term hazards to the aquaticenvironment

Category 2(nervoussystem)
Category 3(respiratoryirritation)
Category 1(respiratoryorgans)Category 2(nervoussystem, kidney)
Classification notpossibleClassification notpossibleClassification notpossible<Washing Solution I>
Classification notpossible

Category 2(nervoussystem)

Classification notpossible

Category 2(nervoussystem, kidney)

Classification notpossibleClassification notpossibleClassification notpossibleClassification notpossibleClassification notpossible
Category 3
Category 3

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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
2 Hazards identification(Continued)
Label elements<Magnetic beads>
Pictograms or symbols
Signal word
Hazard statements

Danger
Causes skin irritation
Causes serious eye irritation
Suspected of damaging fertility or the unborn childMay cause respiratory irritation
Cause damage to respiratory organs through prolonged or repeated exposure
May cause damage to nervous system
May cause damage to nervous system and kidney through prolonged orrepeated exposure

Precautionary statements
Prevention

Response

Storage
DisposalObtain special instructions before use.
Do not handle until all safety precautions have been read and understood.
Wear protective gloves/protective clothing/eye protection / face protection.
Use only outdoors or in a well-ventilated area.
Do not breathe dust / fume / gas / mist / vapours /spray.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
If inhaled: Remove person to fresh air and keep comfortable for breathing.
Call a POISON CENTER or doctor if you feel unwell.
IF ON SKIN: Wash with plenty of water and soap.
Take off contaminated clothing and wash it before reuse.
If skin irritation occurs: Get medical advice/attention.
If in eyes: Rinse cautiously with water for several minutes. Remove contactlenses, if present and easy to do. Continue rinsing.
If eye irritation persists: Get medical advice / attention.
IF exposed or concerned: Get medical advice/attention.
Get medical advice/attentions if you feel unwell.
Store locked up.
Store in a well-ventilated place. Keep container tightly closed.
Dispose of contents / container in accordance with local / regional / national/international regulation.

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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
2 Hazards identification(Continued)<Lysis&Binding Solution>
Pictograms or symbols

Signal word
Hazard statements

Precautionary statementsPrevention

ResponseStorage
Disposal

Warning
Harmful if swallowed
Cause skin irritation
Causes serious eye irritation
Suspected of damaging fertility or the unborn child
May cause damage to nervous system
May cause damage to nervous system and kidney through prolonged orrepeated exposure
Obtain special instructions before use.
Do not handle until all safety precautions have been read and understood.

Wash hands thoroughly after handlingDo not eat, drink or smoke when using this product.
Wear protective gloves/protective clothing/eye protection/face protection.
Do not breathe dust/fume/gas/mist/vapours /spray.
IF ON SKIN: Wash with plenty of water and soap.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses if present and easy to do. continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Call a POISON CENTER or doctor if you fell
unwell. Rinse mouth.
Store locked up.
Dispose of contents / container in accordance with local / regional / national/international regulation.

<Washing Solution>
Pictograms or symbols

Signal word
Hazard statements

Warning
Harmful if swallowed
Cause skin irritation
Causes serious eye irritation
Harmful to aquatic life with long lasting effects

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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
2 Hazards identification(Continued)
Precautionary statements
Prevention

Response

Disposal

Wash hands thoroughly after handlingDo not eat, drink or smoke when using this product.
Wear protective gloves/eye protection/face protection.
Avoid release to the environment.
IF ON SKIN: Wash with plenty of water and soap.
If skin irritation occurs: Get medical advice/attention.
Take off contaminated clothing and wash it before reuse.
IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses if present and easy to do. continue rinsing.
If eye irritation persists: Get medical advice/attention.
IF SWALLOWED: Call a POISON CENTER or doctor if you fell
unwell. Rinse mouth.
Dispose of contents / container in accordance with local / regional / national/international regulation.

3 Composition/information on ingredients
Chemical product (a substance or a mixture)

Chemical Nature
Parts Name
<Magnetic Beads><Lysis & Binding Solution><Washing Solution>
Components Contributing to the Hazard
Common Chemical Name(or Generic Name)

Mixture<Lysis & Binding Solution>, <Washing Solution>; aqueous solution<Magnetic Beads>; aqueous dispersion
Main components
Magnetic Beads (Silicon dioxide, triiron tetraoxide)
Lithium Chloride
Guanidine Hydrochloride
di-Sodium Dihydrogen Ethylenediaminetetraacetate
Dihydrate
Poly(oxyethylene) octylphenyl ether
Guanidine Hydrochloride
Poly(oxyethylene) octylphenyl ether
Silicon dioxide

triiron tetraoxide

Synonyms

colloidal silica

iron(II) iron(III) oxide

Contained Parts:Percentage

Magnetic Beads:
15～30%

Magnetic Beads:
5～15%

7631-86-9

1317-61-9

CAS No.
Common Chemical Name(or Generic Name)
Synonyms
Contained Parts:Percentage
CAS No.

Lithium Chloride

Poly(oxyethylene)
octylphenyl ether
TritonX-100

Lithium Chloride
Magnetic Beads:
Lysis&Binding Solution
20%
Washing Solution I:
Lysis&Binding Solution:<1%
10%7447-41-8
9002-93-1

CAS No. (EC No.)7447-41-8
50-01-1
6381-92-6
9002-93-1
50-01-1
9002-93-1
Guanidine Hydrochloride
Guanidinium
Hydrochloride
Lysis&Binding Solution
Washing Solution:
45～65%
50-01-1

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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
4 First-aid measures
Inhalation
Skin contact

Eye contact

Ingestion
Most important symptoms/effects

In case of irritation by inhaling this product, move affected person to fresh air.
Call a POISON CENTER or doctor if you feel unwell.
Take off immediately all contaminated clothing. Wash with plenty of cleanwater, immediately. If skin irritation occurs: Get medical advice/attention.
Rinse cautiously with water for several minutes. Remove contact lenses, if
present and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice / attention.
Rinse mouth. Call a POISON CENTER or doctor/physician if you fell unwell.
Do not induce to vomiting.
Inhalation, Ingestion: Cough, Diarrhea
Skin, Eye: Pain, Redness

5 Fire-fighting measures
Extinguishing media
Precautions for fire-fighters

Powder, Carbon Dioxide, Foam, Dry sandFire-fighting should be done from the windward side of fire area. Fire-fightersshould wear proper protective equipment in case of large scale fire.

6 Accidental release measures
Personal precautions
Environmental precautions
Methods for cleaning up

Wear protective gear to avoid eye/skin contact and inhalation.
Avoid disposition to the environment.
Use cloth, paper or anything similar to soak up the solution leaking out of thecontainer. Take up under vacuum using dust collecting filter.

7 Handling and storage
Handling
Technical measures
Precautions
Hygiene measures
StorageTechnical measures
Packaging Materials

Wear protective equipment and avoid contact with eyes and skin.
Wear protective equipment and avoid contact with eyes and skin.
Handle the reagent not to generate aerosol or dust.
Do not eat, drink or smoke when using this product. Wash hands thoroughly
after handling.
Keep tightly closed and store at about 2-8℃.
Store in the original package

8 Exposure controls and personal protection
Engineering controls
Personal protective equipment
Respiratory protection
Hand protection
Eye protection
Skin and body protection

Set up good ventilation and exhaust system in the work area. Provide shower
and vanity unit nearby.
Wear a dust mask.
Chemical safety gloves.
Chemical safety goggles.
Wear lab coat when needed.

9 Physical and chemical properties
Physical State
ColourpH
Flash point
Explosion limit
Density
Solubility

LiquidBrown suspension(Magnetic Beads), Clear solution(Others)
7.0～8.0
No flammability due to aqueous solution
Not explosive
Not available
Soluble in water except for Magnetic Beads .

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MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
10 Stability and reactivity
Chemical stability and hazardous reactions
Conditions to Avoid
Incompatible materials
Hazardous decomposition products

Stable under normal handling.
Strong oxidizers
carbon monoxide, nitrogen oxides, chlorine, hydrogen chloride

11 Toxicological information
Acute toxicity
May be harmful if swallowed
Skin irritation/corrosion
May cause eye and skin irritation.
Specific target organ toxicity-single exposure
May cause respiratory irritation.
Toxicological information on the component of this product
Silicon dioxide
triiron tetraoxide
Acute toxicity
not available
not classified

Skin corrosion/Irritation
Eye damage/irritation
Carcinogenicity
Specific target organ toxicity-single exposure

not available
not available
IARC Group 3
Not available

Specific target organ toxicity-repeatedexposure

Not available

Triton X-100
Acute toxicity
Oral-rat:
LD50 1800mg/kg
Dermal-rabbit:
LD50 >3000mg/kg

Skin corrosion/Irritation
Eye damage/irritation
Carcinogenicity
Specific target organ toxicity-single exposure

Specific target organ toxicity-repeatedexposure

not classified
Category 2
not available
Category 3(respiratory tractirritation)
Category 1(respiratoryorgans)
Lithium Chloride
Category 4
Oral-rat:
LD50 526mg/kg
Dermal-rabbit:
LD50 >2000mg/kg
Inhalation-rat:
LC50 5.57mg/L(dust)

Not available
Category 2A
Not available

Category 2
Category 2A
not available

Not available

Category 2(Central Nervous System)

Not available

Category 2(Central NervousSystem,renal)

Guanidine Hydrochloride
Category 4
Oral-rat:
LD50 774mg/kg
Dermal-rabbit:
LD50 >2000mg/kg
Inhalation-rat:
LC50 5.319mg/L(dust)
Category 2
Category 2A
not available
not available

not available7 / 7 ページ

MagExtractorTM -RNAFirst issue: June. 1, 2017
Revised issue:
SDS No. 1415F

Safety Data Sheet
12 Ecological information
EcotoxicityPersistence and degradability
Bioaccumulative potential
Mobility in soil

Not available
Not available
Not available
Soluble in water and diffusible into water environment except for MagneticBeads.

13 Disposal considerations
Waste from residues
Contaminated container and Contaminatedpackaging

Dispose of in accordance with all applicable local and national laws andregulations.
Dispose of in accordance with all applicable local and national laws andregulations.

14 Transport information
International Regulations
UN numberSpecific Precautions

Not classified
Follow all of the laws and regulations in your respective country.
To prevent packages from breaking, handle with care.

15 REGULATORY INFORMATION
Follow all of the laws and regulations in your country.
Substances of very high concern (SVHC) according to REACH.
9002-93-1 Triton X-100

16 OTHER INFORMATION
NoticeThis product is sold for research purposes only . It is not intended for food,drug, household, agricultural or cosmetic use. Its use must be supervised by atechnically qualified individual experienced in handling potentially hazardous
chemicals. The information in this SDS, to the best of our knowledge, isaccurate and correct. However, TOYOBO makes no warranty and assumes noliability whatsoever in connection with any use of this information. Theinformation shall not be taken as being all inclusive and is to be used only aguide. All materials and mixtures may be present unknown hazards and should
be used with caution. The SDS is subject to revision as new information
becomes available.