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Advanced Clinical Research Center

Division of Frontier Surgery
フロンティア外科学分野
Professor
Associate Professor
Assistant Professor
Assistant Professor

Dai Shida, M.D., Ph.D.
Susumu Aiko, M.D., Ph.D.
Yuka Ahiko, M.D.
Shigehiro Kojima, M.D.

教 授
准教授
助 教助 教博士（医学）
博士（医学）
博士（生命医科学）

志愛阿小田甲彦
島友成

大丞
佳浩

The mission of our division is to create solid evidence of surgical treatment forcolorectal cancer as well as gastric cancer by continuously publishing the papers ofclinical research and basic research. If our research can help rewrite various
clinical guidelines around the world, we as surgeons can not only cure the patientsin front of us but also contribute to the development of surgical treatment for
gastrointestinal cancer.

1. Introduction
This division was newly established in September
2020 by professor Shida and Dr. Ahiko. On November
16th, professor Dr. Aiko joined this new division. OnOctober 1th, 2022, Dr. Kojima also joined this division. We named our new division as ‘Frontier Surgery’, because we want to greedily open up undeveloped areas of surgery and contribute to thedevelopment of surgery.
2. Treatment for diseases of colon, rectum, anusand stomach in IMSUT hospital
All of us are also members of Department of Surgery, IMSUT hospital. We treat diseases of colon, rectum, anus, and stomach, especially colorectal cancer
and gastric cancer. We also perform laparoscopic surgery for inguinal hernias.
See NO16-10 (Department of Surgery, IMSUTHospital).
3. Making Evidence for gastrointestinal malignancy
While performing surgery as gastrointestinal sur-geons, we are planning to conduct translational research as academic surgeons in the near future.
4. Publications
Refractory Intestinal Behçet-Like Disease Associated with Trisomy 8 Myelodysplastic Syndrome Resolved by Parenteral Nutrition.
Takahashi R, Matsubara Y, Takahashi S, Yokoyama
K, Ahyoung LL, Koga M, Sakamoto H, Boku N, Shida D, Yotsuyanagi H.
Case Rep Gastroenterol. 2023 Oct 11;17(1):287-293.
Prognostic factors associated with the transition intreatment methods for brain metastases from colorectal cancer.
Imaizumi J, Shida D, Boku N, Igaki H, Itami J, Miyakita Y, Narita Y, Takashima A, Kanemitsu Y.
Int J Clin Oncol. 2023 Aug;28(8):1043-1053.
Genomic landscape and its prognostic significancein stage III colorectal cancer: JCOG1506A1, an ancil-132
lary of JCOG0910.
Shida D, Kuchiba A, Shibata T, Hamaguchi T,Yamasaki S, Ito M, Kobatake T, Tonooka T, Masaki
T, Shiozawa M, Takii Y, Uetake H, Okamura S, Ojima H, Kazama S, Takeyama H, Kanato K, ShimadaY, Murakami Y, Kanemitsu Y.
Cancer Sci. 2023 Aug;114(8):3352-3363.
Bromodomain protein BRD8 regulates cell cycle
progression in colorectal cancer cells through a
TIP60-independent regulation of the pre-RC complex.
Yamaguchi K, Nakagawa S, Saku A, Isobe Y, Yamaguchi R, Sheridan P, Takane K, Ikenoue T, Zhu C,Miura M, Okawara Y, Nagatoishi S, Kozuka-Hata
H, Oyama M, Aikou S, Ahiko Y, Shida D, Tsumoto
K, Miyano S, Imoto S, Furukawa Y.
iScience. 2023 Apr 1;26(4):106563.
Comparison of clinicopathological and genomic
profiles in anal squamous cell carcinoma between
Japanese and Caucasian cohorts.
Ito T, Takayanagi D, Sekine S, Hashimoto T, Shimada Y, Matsuda M, Yamada M, Hamamoto R, Kato T,
Shida D, Kanemitsu Y, Boku N, Kohno T, Takashima A, Shiraishi K.
Sci Rep. 2023 Mar 3;13(1):3587. doi: 10.1038/
s41598-023-30624-w.
Effect of Biologics on the Risk of Advanced-Stage
Inflammatory Bowel Disease-Associated Intestinal
Cancer: A Nationwide Study.
Seishima R, Okabayashi K, Ikeuchi H, Uchino M,
Futami K, Noguchi T, Ohge H, Iseki Y, Watanabe K,Itabashi M, Okamoto K, Toiyama Y, Ogino T, Nakamura M, Yamada K, Wakai T, Sato Y, Kimura H,Takahashi K, Hida K, Kinugasa Y, Ishida F, Okuda
J, Daito K, Koyama F, Ueno H, Yamamoto T,Yamamoto S, Hanai T, Maemoto A, Arakaki J, Komori K, Akagi Y, Shida D, Yamaguchi S, Matsuda K,Maeda K, Noake T, Nezu R, Sasaki S, Hasegawa J,Sunami E, Kanemitsu Y, Katsumata K, Uehara K,Kiyomatsu T, Suto T, Kazama S, Yamada T, Goi T,Ishihara S, Ajioka Y, Sugihara K.
Am J Gastroenterol. 2023 Jul 1;118(7):1248-1255.
Prognostic differences between oligometastaticand polymetastatic disease after resection in patientswith colorectal cancer and hepatic or lung metastases:
Retrospective analysis of a large cohort at a single institution.

Horie T, Kanemitsu Y, Takamizawa Y, Moritani K,
Tsukamoto S, Shida D.
Surgery. 2023 Feb;173(2):328-334.
Identification of odontogenic ameloblast associated as a novel target gene of the Wnt/β-catenin signaling pathway.
Yamaguchi K, Horie C, Takane K, Ikenoue T, Nakagawa S, Isobe Y, Ota Y, Ushiku T, Tanaka M, Fujishiro J, Hoshino N, Arisue A, Nishizuka S, Aikou S,Shida D, Furukawa Y.
Cancer Sci. 2023 Mar;114(3):948-960.
Risk of non-colorectal cancer-related death in elderly patients with the disease: A comparison of five
preoperative risk assessment indices.
Yasui K, Shida D, Ahiko Y, Takamizawa Y, Moritani
K, Tsukamoto S, Kanemitsu Y.
Cancer Med. 2023 Feb;12(3):2290-2302.
Prognostic Role for Primary Tumor Location inPatients With Colorectal Liver Metastases: A Comparison of Right-Sided Colon, Left-Sided Colon, and Rectum.
Takamizawa Y, Shida D, Horie T, Tsukamoto S, Esaki M, Shimada K, Kondo T, Kanemitsu Y.
Dis Colon Rectum. 2023 Feb 1;66(2):233-242.
Prognostic Factors of Bone Metastases FromColorectal Cancer in the Era of Targeted Therapy.
Kobayashi Y, Shida D, Boku N, Yasui K, Nakamura
Y, Kudose Y, Imaizumi J, Kanemitsu Y.
Dis Colon Rectum. 2023 Mar 1;66(3):401-409.
Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps topredict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junctioncancer not treated with neoadjuvant chemotherapy.
Shiomi S, Yagi K, Iwata R, Yajima S, Okumura Y,Aikou S, Yamashita H, Nomura S, Seto Y.
Surg Endosc. 2023 Nov;37(11):8214-8226.
Utility of the revised FIGO2023 staging with molecular classification in endometrial cancer.
Kobayashi-Kato M, Fujii E, Asami Y, Ahiko Y, Hiranuma K, Terao Y, Matsumoto K, Ishikawa M,

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Kohno T, Kato T, Shiraishi K, Yoshida H.
Gynecol Oncol. 2023 Nov;178:36-43.
Artificial intelligence for the recognition of key anatomical structures in laparoscopic colorectal surgery.
Kitaguchi D, Harai Y, Kosugi N, Hayashi K, Kojima
S, Ishikawa Y, Yamada A, Hasegawa H, Takeshita N,Ito M.
Br J Surg. 2023 Sep 6;110(10):1355-1358.
Automatic Surgical Skill Assessment System
Based on Concordance of Standardized Surgical Field
Development Using Artificial Intelligence.
Igaki T, Kitaguchi D, Matsuzaki H, Nakajima K,
Kojima S, Hasegawa H, Takeshita N, Kinugasa Y,
Ito M.
JAMA Surg. 2023 Aug 1;158(8):e231131. doi:
10.1001/jamasurg.2023.1131. Epub 2023 Aug 9.
Deep-learning-based semantic segmentation ofautonomic nerves from laparoscopic images ofcolorectal surgery: an experimental pilot study.

Kojima S, Kitaguchi D, Igaki T, Nakajima K, Ishikawa Y, Harai Y, Yamada A, Lee Y, Hayashi K, Kosugi N, Hasegawa H, Ito M.
Int J Surg. 2023 Apr 1;109(4):813-820.
Universal meta-competencies of operative performances: a literature review and qualitative synthesis.
Igaki T, Takenaka S, Watanabe Y, Kojima S, Nakajima K, Takabe Y, Kitaguchi D, Takeshita N, Inomata M, Kuroyanagi H, Kinugasa Y, Ito M.
Surg Endosc. 2023 Feb;37(2):835-845.
Assessment of Elastic Laminal Invasion Contributes to an Objective pT3 Subclassification in ColonCancer.
Kojima M, Yokota M, Yanagisawa N, Kitamura S,Amemiya K, Kawano S, Tsukada Y, Sakuyama N,Nagayasu K, Hashimoto T, Nakashima K, Jiang K,
Kanemitsu Y, Fujita F, Akiba J, Notohara K, Itakura J, Sekine S, Sakashita S, Sakamoto N, Ishikawa
S, Nakanishi Y, Yao T, Liang WY, Lauwers GY, Ito
M, Sakamoto K, Ishii G, Ochiai A.
Am J Surg Pathol. 2023 Oct 1;47(10):1122-1133.