INNOVATION Z Project No.1
Innovation by TMR series

Our approach to safety

Unique technology reduces the burden on the patients

To create "safety" and "value"
As medical sophistication advances, the level of sophistication required in production, fromresearch and development to manufacturing and shipping, is also increasing. YAMAKIN isstrengthening relationships with external organizations and implementing world-classquality management, striving to provide safety and value.

Verification of Biological Safety
YAMAKIN established the Biological Science and Safety Laboratory in the Department ofOral and Maxillofacial Surgery, Kochi Medical School, Kochi University, Japan. We have been
researching and analysing the safety risks of dental materials by the evaluation of various
biological safety factors such as allergenicity, carcinogenicity, influence on our descendants,
and so on.

YAMAKIN’s Manufacturing Environment
All manufacturing processes for the TMR series are conducted in clean rooms and controlled extremely strictly.

Clean room in the YAMAKIN Kochi factory

Manufacturer

1090-3 Otani, Kamibun, Kagami-cho,
Konan-shi, Kochi, 781-5451 Japan

https://www.yamakin-global.com

Head Office: 3-7 Sanadayama-cho Tennoji-ku Osaka 543-0015, Japan
Branch Office: Tokyo, Osaka, Sendai, Nagoya, Fukuoka, JAPAN
Factory and R&D: Kochi, JAPAN
P: +81-887-55-0281 F: +81-887-55-0053
E: contact@yamakin-gold.co.jp

INTERNATIONAL20200928

Applicable from pulp capping to filling
TMR-MTA cement Mielle
Improved X-ray radiography by 60%

Innovation by TMR Series

Excellent usability with quick setting- Easy mixing- Japan made MTA cement features various
advantages such as Bismuth Free.

CR
Adhesive
MTA

MTA＋ Adhesive ＋＝CRTMR Series

TMR-AQUA BOND 0
Shorten the chair time.

TMR series are developed and commercialized with ideals such as“no extracting”,“minimal grinding”and“preserving teeth”based on the MI concept (minimal intervention).

Zero second bonding- Stable adhesive strength in the wet condition- Zero second demineralization reduces the burden on the patients.
Note: It suppresses lowering of adhesion caused by moisture which clinically cannot be removed.

TMR Series Technical Concept
M-TEG-P

M-TEG-P

G-P-PTEG

EM-TM--PTMR-MTA cement Mielle

EG-TM

TMR-AQUA BOND 0

TMR-MTA cement Mielle

Zirconia Fine Particles

Even though TMR-MTA cement Mielle, which will set with water, contains moisture, a compatible adherence surface
can be assured, because TMR-AQUA BOND 0, which contains the phosphoric monomer M-TEG-P®, has amphiphilic
property. Moreover, adherence is enabled even under moist conditions by the chemical interaction between
zirconia, which is employed as a replacement for bismuth oxide, and the phosphate group of M-TEG-P.
Moreover, TMR-Z Fill 10. using YAMAKIN’s filler technology, achieves both sustained fluoride release and highstrength. Introduction the TMR series completes the total system from pulp capping to filling, with the long-term
mission of“preserving teeth”in mind.

2

TMR-Z Fill10.

Achieves both sustained fluoride
release property and strength.
- YAMAKIN’s unique filler technology enables the both
high strength and sustained fluoride release3

1

Controlled medical device - Dental pulp capping material

4

MTA cement with improved X-ray radiopacity

High Compressive Strength

By increasing and optimizing the amount of zirconia, x-ray contrast or radiographic is improved by 60% compared to ourSince it sets quickly, the product achieves highprevious product, making it easier to observe by x-ray and CT.

compressive strength (about 90 MPa) from one

Compressive Strength(MPa)TMR-MTA cement Mielle

Excellent usability with quick setting“MTA cement”made in Japan throughindustry-academia collaboration

Conventional
product

X-ray radiopacity (mm Al)

day after application. The compressive strength

Prototype containing
20% of Bismuth oxide

5reaches about 140 MPa after a week, matching

60 %UP

the compressive strength of glass ionomer

4cement.

31 Day Later

5

Conventional
product

Quick Setting
Since it can be mixed with a small amount ofMoisture Ratio(Powder : Water)

State ofPaste

HandlingTime

Initial SettingTime

20% (0.2g : 0.05g)

Standard

About 3 min.

15-30 min.

the moisture with a moistened cotton pellet

25% (0.2g : 0.07g)

Soft

About 6 min.

30-40 min.

after application. If the paste gets dry and

30% (0.2g : 0.09g)

Very Soft

About 9 min.

40-60 min.

water, the product sets quickly so that initial
setting is completed in 15 to 30 minutes. Also, it
Exposure time of LED irradiator

biological cases, such as in dental materials and0 second

10 seconds

30 seconds

sets sufficiently without any need to replenish

90 seconds

joint prosthesis.
Whitedifficult to handle, the viscosity of the paste canchange of color is unlikely to happen.

be adjusted by adding moisture.
Light Ivory

6

Prototype containing
20% of Bismuth oxide

At the moment the cement comes into contact with water,

More details!

it is absorbed and becomes cement mud.

Video Clip

The bearing effect of the spherical silica particles improves4

How to use TMR-MTA cement Mielle

Calcium silicateparticlethe product’s fluidity. This enables you to make an evenare the round shape, easy operation remains.

Biocompatibility
capping with TMR-MTA cement Mielle.

Easy to Mix with a Small Amount of Water

particles to improve the X-ray contrast, since the particles

Note 1: As indicated in the above chart, the initial setting time will be longer if the paste is softer.
Remove excess moisture with a dry cotton pellet etc. after application.
Note 2 : Note that in cases where the moisture ratio becomes 35% or more, remarkably the initial
setting will become slow and the compressive strength will decrease.

New formation of dentine is confirmed, with odontoblast-like cells arrayed in a fence-like formation 1 week after direct pulp

Note: Verified under oxygen insulated condition by glycerin.

Although we have increased the number of zirconia

1 Week Later

Moisture Ratio: 20 mass%

Bismuth Free

paste easily with a small amount of water in a short time.

40

1Zirconia is used as a radiographic agent for various

380

00Zirconia is a chemically stable substance soConventional product120

2The percentage of calcium silicate (76vol%), which is the main ingredient, remains
unchanged from the previous product. The percentage of alkaline and calcium ionsreleasing amount are also same. So, the basic performance of MTA cement, is maintained.

2160

Video clip for instructions
on how to use MTA cement
can be found on the website.

Spherical
silica particle
Zirconia
particle

Improving fluidity

Report
TMR-MTA cement Mielle

Product report

Ball bearing
Image of bearing effect5

Shorten the chair time.

Zero second bonding

TMR-AQUA BOND 0
Controlled medical device - Dental Adhesive for Enamel and Dentine (Dental adhesive for ceramics) (Dental adhesive for metal)○2 Applying AQUA BOND 0

5 After the Treatment

Apply AQUA BOND 0 to the whole surface ofthe cavity.
Air drying can be performed immediately
after applying.
Light cure for 3 sec. with a LED light whoselight intensity is 2,400 mw/cm2.

Z Fill10. has both sustained fluoride release andstrength, along with the aesthetic advantage ofbeing like a natural tooth. This will improve thepatient’s QOL.

YAMAKIN’s Technology

M-TEG-P Technology
Exhibits both hydrophilicity
and lipophilicity

OOOOPolymerizing
group

Amphiphilic partO

The adhesive component M-TEG-P has anamphiphilic spacer base. Therefore, consistentadhesion and uniformity are achieved, evenunder moist conditions.
OO P OHOHPhosphate
group

M-TEG-P is a registered trademark ofYAMAKIN CO., LTD.

More details!
AQUA BOND 0

Filling minute roughnesses on the tooth surface caused by milling andCRCR

tightly. Furthermore, it enables a bonding layer (5 to 10 μm) that is as thin

Video Clip

AQUA BOND CHALLENGE
Check it out the video clip showing
the high adhesive strength of AQUABOND 0.

as possible and as uniform as possible, it fully demonstrates the physicalstrength of the composite.
Enamel6

Porcelain material －Improves Bonding Strength of Composite○No Separation

creating smooth surface bonding layers enables the composite to adhere

As the Universal type has good formability,
delicate repair work is possible.
The A5 shade will be useful when there is lessgrinding.
Light cure for 4 sec. with a LED light whose lightintensity is 2,400 mw/cm2.

Fill the cavity with the Flow type which has
appropriate flowability. Many shades in theline-up enables the dental technician’s image
to be reproduced aesthetically.
Light cure for 4 sec. with a LED light whoselight intensity is 2,400 mw/cm2.

effective ingredients for adhesion to be applied uniformly.

44 Filling with Z Fill10. Universal

Form a cavity in accordance with normal
practice.
AQUA BOND 0 achieves consistent adhesion
even in a moist condition.

3 Filling with Z Fill10. Flow

between lipophilic monomers and water; therefore, this enables the－30 min Later

Resin

Right After BeingDischarged－

30 minutes under light-shielding conditions, there is no phase separation○No Separation After Taken Out
With precise control of ingredient blending and M-TEG-P, even after about

1 Forming a Cavitylight curing 3sec

In case of using a LED light whose light intensity is 2,400mW/cm2.

(including inorganic material)

oral cavity.

Restoration of cavity (Photos provided by: YAMAKITA DENTAL OFFICE (Kochi, Japan)

demineralized 0sec

elderly people, because of the shortened time required for operation inGold-silverpalladium alloy

TMRAQUA BOND 0－AQUA BOND 0 can be used for various applications, such as children or○reduced.

light curing

Silver alloy

demineralized[Clinical case for using AQUA BOND 0 and Z Fill 10.]Multi Primer LIQUID +TMR-AQUA BOND 0－Dentine○EnamelTMR-AQUA BOND 0－

Multi Primer LIQUID as pretreatment.

0○

containing inorganic fillers during intraoral repair with using

2Gold alloy

porcelain, CAD/CAM produce crowns, and resin materials

4－during CR treatment and intraoral repair. It also can adhere to6○8Titanium

tooth structure to zirconia, titanium and precious metals

10YAMAKINconventional
product

As time for demineralization is unnecessary, the burden on patients can be

TMR-AQUA BOND 0 can bond a wide range of materials from－12The substances in the table can be usedThanks to M-TEG-P and other adhesive components,○14No Waiting Time for Demineralization (Tooth is demineralized quickly after application.)
One liquid, one step. A simplified adhesion step is employed.

3

Dry condition
Moist condition

Zirconia

16Adheres to Various Materials
Tooth substance

Moisture is necessary for demineralization and permeation of toothsubstance in adhesion, but excess moisture is known to adversely affectadhesion. AQUA BOND 0 achieves consistent adhesion without sensitivity
to moisture conditions, i.e., in both dry and moist conditions, withuser-friendly application protocols due to the effects of one of theadhesive components, M-TEG-P.
An adhesive which prevents reduction of bonding strength caused bymoisture (which cannot be removed clinically) has been developed.

25

Advanced Adhesion and Speed
Tensile bond strength(MPa)1Report
TMR-AQUA BOND 0Product report

An adhesive that has realized
rapid treatment under moistconditions.

Dentine73Achieves Both Sustained Fluoride Release

Comprehensive Shade Line-Up

Property and Strength

Basic Shade

Opaque ShadeWhiteningEnamel

Only Universal type offers a line-up
from B1 to D2 of the standard shades.
Only Flow and Low Flow types
offer a line-up from OA3.5 to OA5.

TMR -Z Fill10.
In combination with the filler technology, excellent light scattering property was achieved while maintaining the same

Controlled medical device -Resin-based Dental Restorative Materialtransmittance as our conventional products.
A“chameleon effect”can be expected from this characteristic since the light scatters so that the surrounding colors become morenatural. Furthermore, A5 and OA5 shades have been added to the line-up for Z Fill10., and good aesthetics can be obtained even

Achieves Both Sustained Fluoride Release Property and Strength
is long-term sustained fluoride releaseachieved but also high strength anddurability.
It has fluorine recharge characteristics,
taking in fluorine contained in
toothpaste and mouthwash andreleasing it.

Universal type
Flow type

8Flexural Strength (MPa)Using this filler technology, not only

Cumulative sustained fluoride ion
release amount(μg/cm2)

164200102030

4050

Immersing days

60

in cervical areas in elderly people or where the milling amount was small.

Before thermal cycle test
After 5,000 thermal cycles

200

Shade line-up
Product name

160
120

Z Fill10. Universal

80400Z Fill10. Flow
UniversalFlow

Low Flow

Note: ISO 4049:2009，
Dentistry−Polymer-based restorative materials.

Z Fill10. Low Flow

Category

A1A2

A3 A3.5 A4A5B1B2

B3C2C3D2Dentine

●●●●●

●

●

●

●

●

●

●
●

OpaqueDentine●OpaqueDentine●Opaque

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●

●Others

QTY of shadeContents

BW, E, OW

17

3.8g (2mL)

BW, E, OW

14

2.6g (1.5mL)

BW, E, OW

14

2.6g (1.5mL)

BW: Bleaching White E: Enamel OW: Opaque White

2Outstanding Usability
Universal is easily releasable from a spatula,

YAMAKIN’s Technology

but its viscosity allows it to stretch smoothly. InCeramics Cluster Filler

addition, as Flow and Low Flow haveappropriate flowability, it is easy to fill or place

Ceramics cluster filler (C.C.F.) is YAMAKIN’s original technology.

them as desired.

C.C.F. consists of three kinds of filler whose uneven surfaces areintertwined together. By this “anchoring effect”, it exhibits highFormability of Universal

Flowability of Flow (Left)
Low Flow (Right)

strength. Moreover, the combination of the sustained fluoride
release property and high strength, which is difficult toachieved in general by adding sustained fluoride release filler.

Ceramics Cluster Filler (1~20μm)
Spherical Nano-Filler (SiO2: 20nm)
Sustained Fluoride Release Filler(Glass: Approx. 700 nm)

Organic and inorganic composite filler(3~5μm)Note: more minute glass fillers than for C.C.F were used in Flowand Low Flow to give excellent flow control.

More details!
Video Clip

TMR-ZFill10.
CHAMELEON EFFECT8◀ Image of Z Fill10. (Universal)

Report
TMR-Z Fill 10.

Product report

The concept of having both a sustained fluoride release property and high strength was first commercialized in HR blocks for CAD/CAM

Composite Resin: In Pursuit ofSustained Fluoride Release,High Strength and Operability

crowns: KZR-CAD HR BLOCK 2. Members of the development project were awarded the “Excellence Prize” for the product in thetechnological development category of the “Seventh Monodzukuri Nippon Grand Awards” by The Ministry of Economy, Trade andIndustry (METI).

9

Direct Composite Resin
Controlled medical device - Dental pulp capping material

Controlled medical device -Resin-based Dental Restorative Material
Single Package

UNIVESAL

Dental Pulp Capping Material

TMR-Z Fill10. Universal 3.8g (2mL)

Single Package

TMR-Z Fill10. Flow 2.6g (1.5mL)

TMR-MTA cement Mielle (White, Light Ivory)
・Glass Container / Bottle Type (3g)・Accessory: Spoon (1 pc.)

Accessory. Needle Tip: 10 pcs.

TMR-Z Fill10. Low Flow 2.6g (1.5mL)
Accessory. Needle Tip: 10 pcs.
Set Package

TMR-MTA cement Mielle (White, Light Ivory)
・Microtube Type (0.2g) : 3 pcs.

TMR-MTA cement Mielle (White, Light Ivory)
・Glass Container / Bottle Type (10g)・Accessory: Spoon (1 pc.)

Microtube TypeStandard Pack (each 1 of A1, A2, A3, E)
・Universal・Flow
A1x1, A2x1, A3x1, Enamelx1
・Low Flow

0.2g x3pcs.

2 pcs Pack (each 1 of A2, A3)
・Universal
A2x1, A3x1
・Flow
・Low Flow

FLOW

3 pcs of Same Shade Pack (Each 3pcs.of A2, A3, A3.5)
A2x3
・Universal
A3x3
・Flow
A3.5x3・Low Flow
Accessory

Storage bag withdesiccant to prevent
moisture
Glass Container / Bottle Type

Glass Container / Bottle Type

3g

10g

Needle Tip: 20 pcs.

White

Light Ivory

LOWFLOW

Bonding Material
Controlled medical device - Bonding material for dental metal (dental ceramics, dental resin)
Shade Card is included in each package.

For intraoral repair of restorations(metal, ceramics and resin)
For Repairing hybrid resin or porcelain prosthesis apply Multi Primer first,
then use TMR-AQUA BOND 0 and TMR-Z Fill 10..

Dental Adhesive

Single Package

Controlled medical device

Multi Primer LIQUID (7mL)- Dental Adhesive for Enamel and Dentine (Dental adhesive for ceramics) (Dental adhesive for metal)

Single Package

TMR-AQUA BOND 0 (5mL)

Set Package

TMR-AQUA BOND 0 Set
・TMR-AQUA BOND 0 (5 mL)：1 pc.

・Disposable Applicator Brush：50 pcs.
・Disposable Plate：25 pcs.

Set Package

2 pcs Pack of TMR-AQUA BOND 0Accessory

Disposable Applicator Brush: 50 pcs.
Disposable Plate: 50 pcs.

・TMR-AQUA BOND 0 (5mL)：2 pcs.

More details!
Video clips

YAMAKIN CO., LTD.

M-TEG-P is a registered trademark ofYAMAKIN CO., LTD.

Packages and containers are subject to change without prior notice.

1011