News Release
March 1, 2022
EA Pharma Co., Ltd.

EA Pharma Signed a Worldwide License Agreement of AJT240,
a Treatment for Secondary Hyperparathyroidism, with Pathalys
Pharma, Inc. except Japan, Korea, China, Taiwan and ASEANCountries
EA Pharma Co., Ltd. (President, Hidenori Yabune; Headquarters, Chuo-ku, Tokyo, Japan; "EA Pharma")
announced today that EA Pharma signed a license agreement with Pathalys Pharma, Inc. (President,Neal Fowler; Headquarters, North Carolina, USA; “Pathalys”) to grant Pathalys a worldwide exclusive
license to develop and market a secondary hyperparathyroidism treatment for patients receiving
hemodialysis (Development code, AJT240; Nonproprietary name, upacicalcet sodium hydrate) except
Japan, Korea, China, Taiwan and ASEAN countries.
Secondary hyperparathyroidism (SHPT) is one of the complications that occurs with progression ofchronic renal disease (chronic renal failure). In SHPT, the parathyroid glands excessively secrete
parathyroid hormone (PTH). Excessive PTH promotes efflux of phosphorus and calcium from bone intothe blood. This results in decline of bone density and increase of bone fracture risk. In addition,
phosphorus and calcium are deposited in non-bone tissues (ectopic calcification) to cause arthralgia orother symptoms. Particularly, there has been reported that, when the deposition occurs in the
cardiovascular system, the risk of cardiovascular diseases including arteriosclerosis increases and evencan affect prognosis.
AJT240 directly acts on calcium-sensing receptor on the cell membrane of parathyroid glands andsuppresses the excessive secretion of PTH. AJT240 is an intravenous injection that can be administeredthrough the dialysis circuit intravenously at the end of a dialysis process. This is expected to improvemedication adherence of patients receiving maintenance dialysis and reduce the gastrointestinal side
effects such as nausea, vomiting and the like that are observed in treatment with existing oral SHPT
drugs.
EA Pharma expects that the above license granted to Pathalys will contribute to fulfillment of the unmet
medical needs of patients with SHPT receiving hemodialysis in the world.
EA Pharma will strive to make a contribution to patients, their families and medical practitioners in theworld through development of pharmaceuticals focusing on the gastrointestinal disease area andcreation of new patient value.

EA Pharma Co., Ltd.

More Information

1. About EA Pharma Co., Ltd.
EA Pharma Co., Ltd., a subsidiary of Eisai Co., Ltd. for gastrointestinal disease area, wasestablished in April 2016 by integration of the gastrointestinal business unit with more than 60
year’s history of the Eisai Group and the gastrointestinal business unit of the Ajinomoto Group
having amino acid as its business core. EA Pharma Co., Ltd., is a gastrointestinal specialty
pharmaceutical company with a full value chain covering R&D, production & logistics and sales &marketing.
For further information on EA Pharma Co., Ltd., please visit https://www.eapharma.co.jp/en/
2. About Pathalys Pharma, lnc.
Pathalys Pharma, Inc. is a private, late-stage clinical biopharmaceutical company committed to thedevelopment of advanced therapeutics that address unmet needs in the management of end-stage
kidney disease (ESKD). Pathalys’ initial asset is upacicalcet, a novel calcimimetic with the potential
to improve the treatment of secondary hyperparathyroidism (SHPT). Beyond upacicalcet, Pathalys
continues to identify other high priority needs and potential solutions for patients with ESKD.
Pathalys was seeded by Catalys Pacific and DaVita Venture Group and is headquartered in
Research Triangle Park, North Carolina.
For more information about Pathalys Pharma, lnc., please visit https://www.pathalys.com

3. About Secondary Hyperparathyroidism Treatment “AJT240”
AJT240 was created and developed by Ajinomoto Pharmaceuticals Co., Inc. (now EA Pharma Co.,
Ltd.). For Japan market, EA Pharma signed a license agreement for development and marketing ofAJT240 with SANWA KAGAKU KENKYUSHO CO., LTD. (“SANWA KAGAKU”). SANWA KAGAKU
later singed a co-promotion agreement with Kissei Pharmaceutical Co., Ltd. and launched under thebrand name “UPASITA® IV Injection Syringe” on August 20, 2021. For Korea, EA Pharma singed alicense agreement with JW Pharmaceutical Corporation in 2017; and for China (including Hong Kongand Macao), with TASLY PHARMACEUTICAL GROUP in 2018.

Media Inquiries:
Corporate Planning Dept., EA Pharma Co., Ltd.
TEL：+81-(0)3-6280-9802

EA Pharma Co., Ltd.