I. 欧文原著（Original articles）
1.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Biochemical characterization of the nicotinic cholinergic receptors in human brain: binding of(-)-[3H] nicotine.
J Neurochem. 1985 Aug;45(2):604-10.

2.

Shimohama S, Tsukahara T, Taniguchi T, Fujiwara M.
The binding of 3H-acetylcholine to cholinergic receptors in bovine cerebral arteries.
Life Sci. 1985 Nov 18;37(20):1887-93.

3.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Changes in nicotinic and muscarinic cholinergic receptors in Alzheimer-type dementia.
J Neurochem. 1986 Jan;46(1):288-93.

4.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Biochemical characterization of alpha-adrenergic receptors in human brain and changes in
Alzheimer-type dementia.
J Neurochem. 1986 Oct;47(4):1294-301.

5.

Tsukahara T, Taniguchi T, Shimohama S, Fujiwara M, Handa H.
Characterization of beta adrenergic receptors in human cerebral arteries and alteration of thereceptors after subarachnoid hemorrhage.
Stroke. 1986 Mar-Apr;17(2):202-7.

6.

Tsukahara T, Usui H, Taniguchi T, Shimohama S, Fujiwara M, Handa H.
Characterization of muscarinic cholinergic receptors in human and dog cerebral arteries.
Stroke. 1986 Mar-Apr; 17(2): 300-5.

7.

Tsukahara T, Taniguchi T, Usui H, Miwa S, Shimohama S, Fujiwara M, Handa H.
Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries.
Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):436-43.

8.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Changes in beta-adrenergic receptor subtypes in Alzheimer-type dementia.
J Neurochem. 1987 Apr;48(4):1215-21.
17

9.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Changes in benzodiazepine receptors in Alzheimer-type dementia.
Ann Neurol. 1988 Apr;23(4):404-6.

10.

Tsukahara T, Taniguchi T, Miwa S, Shimohama S, Fujiwara M, Nishikawa M, Handa H.
Presynaptic and postsynaptic alpha 2-adrenergic receptors in human cerebral arteries and theiralteration after subarachnoid hemorrhage.
Stroke. 1988 Jan;19(1):80-3.

11.

Ninomiya H, Taniguchi T, Fujiwara M, Shimohama S, Kameyama M.
Effect of in vivo exposure to hypoxia on muscarinic cholinergic receptor-coupled phosphoinositide
turnover in the rat brain.
Brain Res. 1989 Mar 13;482(1):109-21.

12.

Shimohama S, Rosenberg MB, Fagan AM, Wolff JA, Short MP, Breakefield XO, Friedmann T,
Gage FH.
Grafting genetically modified cells into the rat brain: characteristics of E. coli beta-galactosidase
as a reporter gene.
Brain Res Mol Brain Res. 1989 Jun;5(4):271-8.

13.

Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB,
Shimohama S, Friedmann T, Gage FH.
Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.
Proc Natl Acad Sci U S A. 1989 Nov;86(22):9011-4.

14.

Ninomiya H, Fukunaga R, Taniguchi T, Fujiwara M, Shimohama S, Kameyama M.
[3H] N-[1-(2-thienyl) cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex:
decreases in Alzheimer-type dementia.
J Neurochem. 1990 Feb;54(2):526-32.

15.

Masliah E, Cole G, Shimohama S, Hansen L, DeTeresa R, Terry RD, Saitoh T.
Differential involvement of protein kinase C isozymes in Alzheimer's disease.
J Neurosci. 1990 Jul;10(7): 2113-24.

16.

Shimohama S, Saitoh T, Gage FH.
Differential expression of protein kinase C isozymes in rat cerebellum.
J Chem Neuroanat. 1990 Sep-Oct;3(5):367-75.
18

17.

Fukunaga R, Ninomiya H, Shimohama S, Kimura J, Kameyama M, Taniguchi T.
Reassessment of [3H] glutamate binding to human brain membrane preparations.
Jpn J Pharmacol. 1991 Feb;55(2): 191-6.

18.

Shimohama S, Uehara-Kunugi Y, Terai K, Taniguchi T, Kimura J, Saitoh T.
Expression of protein kinase C isozymes in primary neuronal cultures of the rat cerebellum.
J Neurosci Res. 1991 Jun;29(2):261-70.

19.

Masliah E, Yoshida K, Shimohama S, Gage FH, Saitoh T.
Differential expression of protein kinase C isozymes in rat glial cell cultures.
Brain Res. 1991 May 17;549(1):106-11.

20.

Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J.
Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease.
Brain Res. 1991 Aug 30;558(1):105-108.

21.

Shimohama S, Homma Y, Suenaga T, Fujimoto S, Taniguchi T, Araki W, Yamaoka Y, Takenawa T,
Kimura J.
Aberrant accumulation of phospholipase C-delta in Alzheimer brains.
Am J Pathol. 1991 Oct; 139(4):737-42.

22.

Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J.
Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture.
Biochem Biophys Res Commun. 1991 Nov 27;181(1):265-71.

23.

Nakano S, Shimohama S, Saitoh T, Akiguchi I, Kimura J.
Localization of protein kinase C in human skeletal muscle.
Muscle Nerve. 1992 Apr;15(4):496-9.

24.

Shimohama S, Fujimoto S, Taniguchi T, Kimura J.
Phosphatidylinositol-specific phospholipase C activity in the postmortem human brain: noalteration in Alzheimer's disease.
Brain Res. 1992 May 8;579(2):347-9.

19

25.

Shimohama S, Saitoh T, Gage FH.
Changes in protein kinase C isozymes in the rat hippocampal formation following hippocampal
lesion.
Hippocampus. 1993 Jan;3(1):43-55.

26.

Yamaoka Y, Shimohama S, Kimura J, Fukunaga R, Taniguchi T.
Neuronal damage in the rat hippocampus induced by in vivo hypoxia.
Exp Toxicol Pathol. 1993 Aug;45(4):205-9.

27.

Shimohama S, Narita M, Matsushima H, Kimura J, Kameyama M, Hagiwara M, Hidaka H,
Taniguchi T.
Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains andchanges in Alzheimer's disease.
Neurology. 1993 Jul;43(7):1407-13.

28.

Shimohama S, Fujimoto S, Taniguchi T, Kameyama M, Kimura J.
Reduction of low-molecular-weight acid phosphatase activity in Alzheimer brains.
Ann Neurol. 1993 Jun;33(6):616-21.

29.

Matsushima H, Shimohama S, Yamaoka Y, Kimura J, Taniguchi T, Hagiwara M, Hidaka H.
Alteration of human platelet protein kinase C with normal aging.
Mech Ageing Dev. 1993 Jun;69(1-2):129-36.

30.

Yamaoka Y, Shimohama S, Kimura J, Fukunaga R, Taniguchi T.
Changes in protein kinase C isozymes in the rat hippocampus following transient hypoxia.
Neurosci Lett. 1993 May 14; 154(1-2):20-2.

31.

Shimohama S, Perry G, Richey P, Takenawa T, Whitehouse PJ, Miyoshi K, Suenaga T,
Matsumoto S, Nishimura M, Kimura J.
Abnormal accumulation of phospholipase C-delta in filamentous inclusions of humanneurodegenerative diseases.
Neurosci Lett. 1993 Nov 12; 162(1-2):183-6

32.

Shimohama S, Ogawa N, Tamura Y, Akaike A, Tsukahara T, Iwata H, Kimura J.
Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured
cortical neurons.
Brain Res. 1993 Dec 31;632(1-2):296-302.
20

33.

Shimohama S, Tamura Y, Akaike A, Tsukahara T, Ohara O, Watanabe S, Kimura J.
Brain-derived neurotrophic factor pretreatment exerts a partially protective effect against
glutamate-induced neurotoxicity in cultured rat cortical neurons.
Neurosci Lett. 1993 Dec 24;164(1-2):55-8.

34.

Shimohama S, Fisher LJ, Gage FH.
Intracerebral grafting of genetically modified cells. Applications to a rat model of Parkinson's
disease.
Adv Neurol. 1993; 60:744-8.

35.

Akaike A, Tamura Y, Yokota T, Shimohama S, Kimura J.
Nicotine-induced protection of cultured cortical neurons against N-methyl -D-aspartate receptormediated glutamate cytotoxicity.
Brain Res. 1994 May 2;644(2):181-7.

36.

Uehara-Kunugi Y, Shimohama S, Kobayakawa H, Tamura H, Taniguchi T.
Different modulation of protein kinase C isozymes in dibutyryl cyclic AMP-differentiated PC12h
cells.
J Neurochem. 1994 Jul;63(1):125-32.

37.

Kawamata J, Hasegawa H, Shimohama S, Kimura J, Tanaka S, Ueda K.
Leu106-->Val (CTC-->GTC) mutation of superoxide dismutase-1 gene in patient with familial
amyotrophic lateral sclerosis in Japan.
Lancet. 1994 Jun 11;343(8911):1501.

38.

Kawamata J, Tanaka S, Shimohama S, Ueda K, Kimura J.
Apolipoprotein E polymorphism in Japanese patients with Alzheimer's disease or vasculardementia.
J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1414-6.

39.

Matsushima H, Shimohama S, Tanaka S, Taniguchi T, Hagiwara M, Hidaka H, Kimura J.
Platelet protein kinase C levels in Alzheimer's disease.
Neurobiol Aging. 1994 Nov Dec;15(6): 671-4.

21

40.

Shimohama S, Fujimoto S, Taniguchi T, Kimura J.
The endogenous substrate of low molecular weight acid phosphatase in the brain is an epidermal
growth factor receptor.
Brain Res. 1994 Oct 31;662(1-2):185-8.

41.

Shimohama S, Perry G, Richey P, Praprotnik D, Takenawa T, Fukami K, Whitehouse PJ,
Kimura J.
Characterization of the association of phospholipase C-delta with Alzheimer neurofibrillarytangles.
Brain Res. 1995 Jan 16;669(2):217-24.

42.

Shimohama S, Fujimoto S, Matsushima H, Takenawa T, Taniguchi T, Perry G, Whitehouse PJ,
Kimura J.
Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease.
J Neurochem. 1995 Jun;64(6):2629-34.

43.

Shimohama S, Akaike A, Tamura Y, Matsushima H, Kume T, Fujimoto S, Takenawa T, Kimura J.
Glutamate-induced antigenic changes of phospholipase C-delta in cultured cortical neurons.
J Neurosci Res. 1995 Jun 15;41(3):418-26.

44.

Tsukahara T, Takeda M, Shimohama S, Ohara O, Hashimoto N.
Effects of brain-derived neurotrophicfactor on 1-methyl-4-phenyl-1,2,3,6-tetra hydropyridineinduced parkinsonism in monkeys.
Neurosurgery. 1995 Oct;37(4):733-9; discussion 739-41.

45.

Shimohama S, Fujimoto S, Chachin M, Taniguchi T, Perry G, Whitehouse PJ, Kimura J.
Alterations of low molecular weight acid phosphatase protein level in Alzheimer's disease.
Brain Res. 1995 Nov 13;699(1):125-9.

46.

Maeda T, Shimoshige Y, Mizukami K, Shimohama S, Kaneko S, Akaike A, Satoh M.
Patch sensor detection of glutamate release evoked by a single electrical shock.
Neuron. 1995 Aug; 15(2):253-7.

47.

Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J.
Reduction of platelet phospholipase C activity in patients with Alzheimer disease.
Alzheimer Dis Assoc Disord. 1995 Winter;9(4):213-7.
22

48.

Matsushima H, Shimohama S, Fujimoto S, Takenawa T, Kimura J.
Changes in platelet phospholipase C protein level and activity in Alzheimer's disease.
Neurobiol Aging. 1995 Nov-Dec;16(6):895-900.

49.

Shimohama S, Matsushima H, Fujimoto S, Takenawa T, Taniguchi T, Kameyama M, Kimura J.
Differential involvement of phospholipase C isozymes in Alzheimer's disease.
Gerontology. 1995;41 Suppl 1:13-9.

50.

Sawada H, Shimohama S, Tamura Y, Kawamura T, Akaike A, Kimura J.
Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against
dopaminergic neurons in cultured rat mesencephalon.
J Neurosci Res. 1996 Jan 1;43(1):55-62.

51.

Sawada H, Kawamura T, Shimohama S, Akaike A, Kimura J.
Different mechanisms of glutamate-induced neuronal death between dopaminergic and nondopaminergic neurons in rat mesencephalic culture.
J Neurosci Res. 1996 Feb 15;43(4):503-10.

52.

Shimohama S, Chachin M, Taniguchi T, Hidaka H, Kimura J.
Changes of neurocalcin, a calcium-binding protein, in the brain of patients with Alzheimer's
disease.
Brain Res. 1996 Apr 15;716(1-2):233-6.

53.

Matsushima H, Shimohama S, Chachin M, Taniguchi T, Kimura J.
Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with
Alzheimer's disease.
J Neurochem. 1996 Jul;67(1):317-23.

54.

Chachin M, Shimohama S, Kunugi YU, Taniguchi T.
Assessment of protein kinase C mRNA levels in Alzheimer's disease brains.
Jpn J Pharmacol. 1996 Jun;71(2):175-7.

55.

Fujimoto S, Okano I, Tanaka Y, Sumida Y, Tsuda J, Kawakami N, Shimohama S.
Zinc-ion-dependent acid phosphatase exhibits magnesium-ion-dependent myo-inositol-1phosphatase activity.
Biol Pharm Bull. 1996 Jun;19(6):882-5.
23

56.

Kawakami N, Shimohama S, Hayakawa T, Sumida Y, Fujimoto S.
Tyrosine phosphorylation and translocation of phospholipase C-gamma 2 in polymorphonuclear
leukocytes treated with pervanadate.
Biochim Biophys Acta. 1996 Nov 8;1314(1-2):167-74.

57.

Sawada H, Shimohama S, Kawamura T, Akaike A, Kitamura Y, Taniguchi T, Kimura J.
Mechanism of resistance to NO-induced neurotoxicity in cultured rat dopaminergic neurons.
J Neurosci Res. 1996 Nov 15;46(4):509-18.

58.

Kawasaki H, Moriguchi T, Matsuda S, Li HZ, Nakamura S, Shimohama S, Kimura J, Gotoh Y,
Nishida E.
Ras-dependent and Ras-independent activation pathways for the stress-activated-protein-kinasecascade.
Eur J Biochem.1996 Oct 15;241(2):315-21.

59.

Shimohama S, Akaike A, Kimura J.
Nicotine-induced protection against glutamate cytotoxicity: Nicotinic cholinergic receptormediated inhibition of nitric oxide formation.
Ann N Y Acad Sci. 1996 Jan 17; 777:356-61.

60.

Kawamata J, Shimohama S, Takano S, Harada K, Ueda K, Kimura J.
Novel G16S (GGC-AGC) mutation in the SOD-1 gene in a patient with apparently sporadic
young-onset amyotrophic lateral sclerosis.
Hum Mutat. 1997;9(4):356-8.

61.

Kitamura Y, Shimohama S, Kamoshima W, Matsuoka Y, Nomura Y, Taniguchi T.
Changes of p53 in the brains of patients with Alzheimer's disease.
Biochem Biophys Res Commun. 1997 Mar 17; 232(2):418-21.

62.

Kume T, Kouchiyama H, Kaneko S, Maeda T, Kaneko S, Akaike A, Shimohama S, Kihara T,
Kimura J, Wada K, Koizumi S.
BDNF prevents NO mediated glutamate cytotoxicity in cultured cortical neurons.
Brain Res. 1997 May 9;756(1-2):200-4.

24

63.

Matsuoka Y, Kitamura Y, Fukunaga R, Shimohama S, Nabeshima T, Tooyama I, Kimura H,
Taniguchi T.
In vivo hypoxia-induced neuronal damage in dentate gyrus of rat hippocampus: changes in
NMDA receptors and the effect of MK-801.
Neurochem Int. 1997 Jun;30(6):533-42.

64.

Kawasaki H, Morooka T, Shimohama S, Kimura J, Hirano T, Gotoh Y, Nishida E.
Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced
apoptosis in rat cerebellar granule cells.
J Biol Chem. 1997 Jul 25;272(30):18518-21.

65.

Kihara T, Shimohama S, Sawada H, Kimura J, Kume T, Kochiyama H, Maeda T, Akaike A.
Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity.
Ann Neurol. 1997 Aug;42(2): 159-63.

66.

Kaneko S, Maeda T, Kume T, Kochiyama H, Akaike A, Shimohama S, Kimura J.
Nicotine protects cultured cortical neurons against glutamate-induced cytotoxicity via alpha7neuronal receptors and neuronal CNS receptors.
Brain Res. 1997 Aug 8;765(1):135-40.

67.

Shimohama S, Kamiya S, Taniguchi T, Akagawa K, Kimura J.
Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in
Alzheimer's disease.
Biochem Biophys Res Commun. 1997 Jul 18;236(2):239-42.

68.

Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T.
Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains.
Neurosci Lett. 1997 Nov 14;237(1):17-20.

69.

Kitamura Y, Kosaka T, Shimohama S, Nomura Y, Taniguchi T.
Possible involvement of rapamycin-sensitive pathway in Bcl-2 expression in humanneuroblastoma SH-SY5Y cells.
Jpn J Pharmacol. 1997 Oct;75(2):195-8.

25

70.

Thal LJ, Carta A, Doody R, Leber P, Mohs R, Schneider L, Shimohama S, Silber C.
Prevention protocols for Alzheimer disease. Position paper from the International Working Groupon Harmonization of Dementia Drug Guidelines.
Alzheimer Dis Assoc Disord. 1997;11 Suppl 3:46-9.

71.

Bodick N, Forette F, Hadler D, Harvey RJ, Leber P, McKeith IG, Riekkinen PJ, Rossor MN,
Scheltens P, Shimohama S, Spiegel R, Tanaka S, Thal LJ, Urata Y, Whitehouse P, Wilcock G.
Protocols to demonstrate slowing of Alzheimer disease progression. Position paper from theInternationa Working Group on Harmonization of Dementia Drug Guidelines.
Alzheimer Dis Assoc Disord. 1997;11 Suppl 3:50-3.

72.

The APOE and Alzheimer Disease Meta Analysis Consortium (Shimohama is one of thecontributors)
Effects of age, gender and ethnicity on the association between apolipoprotein E genotype andAlzheimer disease.
JAMA 1997; 278:1349-1356.

73.

Shimohama S, Sasaki Y, Fujimoto S, Kamiya S, Taniguchi T, Takenawa T, Kimura J.
Phospholipase C isozymes in the human brain and their changes in Alzheimer's disease.
Neuroscience. 1998 Feb; 82(4): 999-1007.

74.

Matsushima H, Shimohama S, Kawamata J, Fujimoto S, Takenawa T, Kimura J.
Reduction of platelet phospholipase C-delta1 activity in Alzheimer's disease associated with a
specific apolipoprotein E genotype (epsilon3/epsilon3).
Int J Mol Med. 1998 Jan;1(1):91-3.

75.

Kitamura Y, Kamoshima W, Shimohama S, Nomura Y, Taniguchi T.
Nitric oxide donor-induced p53-sensitive cell death is enhanced by Bcl-2 reduction in humanneuroblastoma cells.
Neurochem Int. 1998 Jan;32(1):93-102.

76.

Kawakami N, Takemasa H, Yamaguchi T, Hayakawa T, Shimohama S, Fujimoto S.
Indication of a protein kinase C-independent pathway for NADPH oxidase activation in humanneutrophils.
Arch Biochem Biophys. 1998 Jan 1;349(1):89-94.

26

77.

Imura T, Shimohama S, Kawamata J, Kimura J.
Genetic variation in the ciliary neurotrophic factor receptor alpha gene and familial amyotrophic
lateral sclerosis.
Ann Neurol. 1998 Feb; 43(2):275.

78.

Shimohama S, Greenwald DL, Shafron DH, Akaika A, Maeda T, Kaneko S, Kimura J, Simpkins
CE, Day AL, Meyer EM.
Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic
damage.
Brain Res. 1998 Jan 1;779(1-2):359-63.

79.

Shimohama S, Sumida Y, Fujimoto S, Matsuoka Y, Taniguchi T, Takenawa T, Kimura J.
Differential expression of rat brain phospholipase C isozymes in development and aging.
Biochem Biophys Res Commun. 1998 Feb 4;243(1):210-6.

80.

Kitamura Y, Shimohama S, Kamoshima W, Ota T, Matsuoka Y, Nomura Y, Smith MA, Perry G,
Whitehouse PJ, Taniguchi T.
Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in
Alzheimer's disease.
Brain Res. 1998 Jan 12;780(2):260-9.

81.

Shimohama S, Saitoh T.
Differential expression of protein kinase C -alpha and -betaII in rat septum and changes following
fimbria-fornix lesion.
Brain Res. 1998 Jan 19;781(1-2):343-7.

82.

Tanaka S, Kawamata J, Shimohama S, Akaki H, Akiguchi I, Kimura J, Ueda K.
Inferior temporal lobe atrophy and APOE genotypes in Alzheimer's disease. X-ray computed
tomography, magnetic resonance imaging and Xe-133 SPECT studies.
Dement Geriatr Cogn Disord. 1998 Mar-Apr;9(2):90-8.

83.

Shimohama S, Kamiya S, Fujii M, Ogawa T, Kanamori M, Kawamata J, Imura T, Taniguchi T,
Yagisawa H.
Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene isassociated with loss of function.
Biochem Biophys Res Commun. 1998 Apr 28;245(3): 722-8.
27

84.

Kihara T, Shimohama S, Urushitani M, Sawada H, Kimura J, Kume T, Maeda T, Akaike A.
Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.
Brain Res. 1998 May 11;792(2):331-4.

85.

Shimohama S, Tanino H, Sumida Y, Tsuda J, Fujimoto S.
Alteration of myo-inositol monophosphatase in Alzheimer's disease brains.
Neurosci Lett. 1998 Apr 10;245(3):159-62.

86.

Tsuji T, Shimohama S, Kimura J, Shimizu K.
m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.
Neurosci Lett. 1998 May 29;248(2):109-12.

87.

Hasegawa H, Hiki K, Sawamura T, Aoyama T, Okamoto Y, Miwa S, Shimohama S, Kimura J,
Masaki T.
Purification of a novel endothelin-converting enzyme specific for big endothelin-3.
FEBS Lett. 1998 May 29;428(3):304-8.

88.

Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Kimura J, Shimohama S.
Dopamine D2-type agonists protect mesencephalic neurons from glutamate neurotoxicity:mechanisms of neuroprotective treatment against oxidative stress.
Ann Neurol. 1998 Jul;44(1):110-9.

89.

Fujimoto S, Tsuda J, Kawakami N, Tanino H, Shimohama S.
myo-Inositol monophosphatase in the brain has zinc ion-dependent tyrosine phosphatase activity.
Gen Pharmacol. 1998 Sep; 31(3):469-75.

90.

Shimohama S, Fujimoto S, Sumida Y, Akagawa K, Shirao T, Matsuoka Y, Taniguchi T.
Differential expression of rat brain synaptic proteins in development and aging.
Biochem Biophys Res Commun. 1998 Oct 9;251(1):394-8.

91.

Shimohama S, Kamiya S, Taniguchi T, Kimura J.
Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in
Alzheimer disease.
Alzheimer Dis Assoc Disord. 1998 Dec;12(4):384-6.

28

92.

Urushitani M, Shimohama S, Kihara T, Sawada H, Akaike A, Ibi M, Inoue R, Kitamura Y,
Taniguchi T, Kimura J.
Mechanism of selective motor neuronal death after exposure of spinal cord to glutamate:involvement of glutamate-induced nitric oxide in motor neuron toxicity and nonmotor neuron
protection.
Ann Neurol. 1998 Nov;44(5):796-807.

93.

Hattori N, Kitagawa K, Higashida T, Yagyu K, Shimohama S, Wataya T, Perry G, Smith MA,
Inagaki C.
CI-ATPase and Na+/K (+)-ATPase activities in Alzheimer's disease brains.
Neurosci Lett. 1998 Oct 2;254(3):141-4.

94.

Kitamura Y, Ota T, Matsuoka Y, Okazaki M, Kakimura J, Tooyama I, Kimura H, Shimohama S,
Gebicke-Haerter PJ, Nomura Y, Taniguchi T.
Kainic acid-induced neuronal loss and glial changes in the hippocampal CA3 of p53-deficientmouse.
Neurosci Lett. 1998 Oct 9;255(1): 57-60.

95.

Sawada H, Ibi M, Kihara T, Urushitani M, Akaike A, Shimohama S.
Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal
death.
J Neurosci Res. 1998 Dec 1; 54(5):707-19.

96.

Shimohama S, Fujimoto S, Sumida Y, Tanino H.
Differential expression of rat brain bcl-2 family proteins in development and aging.
Biochem Biophys Res Commun. 1998 Nov 9; 252(1):92-6.

97.

Tsuda J, Kimura T, Tanino H, Shimohama S, Fujimoto S.
Characterization of high- and low-molecular weight zinc-dependent acid phosphatases in bovine
liver.
Biol Pharmacol Bull 1998; 21:1218-1221.

98.

Kitamura Y, Ota T, Matsuoka Y, Tooyama I, Kimura H, Shimohama S, Nomura Y, GebickeHaerter PJ, Taniguchi T.
Hydrogen peroxide-induced apoptosis mediated by p53 protein in glial cells.
Glia. 1999 Jan 15;25(2):154-64.
29

99.

Kihara T, Shimohama S, Akaike A.
Effects of nicotinic receptor agonists on beta-amyloid beta-sheet formation.
Jpn J Pharmacol. 1999 Mar;79(3):393-6.

100.

Kitamura Y, Shimohama S, Koike H, Kakimura Ji, Matsuoka Y, Nomura Y, Gebicke-Haerter PJ,
Taniguchi T.
Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma
in Alzheimer's disease brains.
Biochem Biophys Res Commun. 1999 Jan 27; 254(3): 582-6.

101.

Shimohama S, Tanino H, Fujimoto S.
Changes in caspase expression in Alzheimer's disease: comparison with development and aging.
Biochem Biophys Res Commun. 1999 Mar16;256(2): 381-4.

102.

Shimohama S, Kamiya S, Taniguchi T, Sumida Y, Fujimoto S.
Differential involvement of small G proteins in Alzheimer's disease.
Int J Mol Med. 1999 Jun;3(6):597-600.

103.

Kawasaki H, Fujii H, Gotoh Y, Morooka T, Shimohama S, Nishida E, Hirano T.
Requirement for mitogen-activated protein kinase in cerebellar long term depression.
J Biol Chem. 1999 May 7;274(19):13498-502.

104.

Kawakami N, Hayakawa T, Shimohama S, Fujimoto S.
The hydroxyl radical formation system in polymorphonuclear leukocytes.
Biol Pharm Bull. 1999 Oct;22(10):1034-7.

105.

Tsuji T, Shimohama S, Kamiya S, Sazuka T, Ohara O.
Analysis of brain proteins in Alzheimer's disease using high-resolution two-dimensional gel
electrophoresis.
J Neurol Sci. 1999 Jul 1; 166(2):100-6.

106.

Kawakami N, Takemasa H, Okamura N, Hayakawa T, Shimohama S, Fujimoto S.
Participation of cytosolic protein phosphatase in regulation of NADPH oxidase inpolymorphonuclear leukocytes.
Biol Pharm Bull. 1999 Jun;22(6):556-60.

30

107.

Tanino H, Yoshida J, Yamamoto R, Kobayashi Y, Shimohama S, Fujimoto S.
Abundance of low molecular weight phosphotyrosine protein phosphatase in the nerve-ending
fraction in the brain.
Biol Pharm Bull. 1999 Aug;22(8):794-8.

108.

Ibi M, Sawada H, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A.
Depletion of intracellular glutathione increases susceptibility to nitric oxide in mesencephalicdopaminergic neurons.
J Neurochem. 1999 Oct;73(4):1696-703.

109.

Imura T, Shimohama S, Sato M, Nishikawa H, Madono K, Akaike A, Kimura J.
Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia:
possible role of beta-adrenergic receptor.
J Neurosci. 1999 Nov 15;19(22):9768-79.

110.

Imura T, Shimohama S, Kageyama T, Kimura J.
Selective induction of glial glutamate transporter GLT-1 by hypertonic stress in C6 glioma cells.
Biochem Biophys Res Commun. 1999 Nov;265(1):240-5.

111.

Kume T, Nishikawa H, Tomioka H, Katsuki H, Akaike A, Kaneko S, Maeda T, Kihara T,
Shimohama S.
p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures.
Brain Res. 2000 Jan 10;852(2):279-89.

112.

Kageyama T, Oeda T, Imura T, Kawamata J, Suzuki S, Tomimoto H, Shimohama S.
Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes.
Neurology. 2000 Jan 11;54(1):265-6.

113.

Yamamoto K, Hashimoto K, Isomura Y, Shimohama S, Kato N.
An IP3-assisted form of Ca2+-induced Ca2+ release in neocortical neurons.
Neuroreport. 2000 Feb 28;11(3):535-9.

114.

Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S.
Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalicneurons.
J Neurochem. 2000 Mar;74(3):1175-84.
31

115.

Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S.
Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons.
J Neurosci Res. 2000 May 1;60(3):321-7.

116.

Sawada H, Ibi M, Kihara T, Urushitani M, Honda K, Nakanishi M, Akaike A, Shimohama S.
Mechanisms of antiapoptotic effects of estrogens in nigral dopaminergic neurons.
FASEB J. 2000 Jun;14(9):1202-14.

117.

Tanino H, Shimohama S, Sasaki Y, Sumida Y, Fujimoto S.
Increase in phospholipase C-delta1 protein levels in aluminum-treated rat brains.
Biochem Biophys Res Commun. 2000 May 19; 271(3):620-5.

118.

Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T,
Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S.
Activation of NADPH oxidase in Alzheimer's disease brains.
Biochem Biophys Res Commun. 2000 Jun 24;273(1):5-9.

119.

Urushitani M, Inoue R, Nakamizo T, Sawada H, Shibasaki H, Shimohama S.
Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor
neurons.
J Neurosci Res. 2000 Aug 15;61(4):443-8.

120.

Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M,
Tsuruo T, Minato N, Shimohama S.
The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier.
Brain Res. 2000 Oct 6;879(1-2):115-21.

121.

Imura T, Shimohama S.
Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia.
J Neurosci Res. 2000 Nov 15;62(4):539-46.

122.

Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A,
Shimohama S.
Protection of cultured spinal motor neurons by estradiol.
Neuroreport. 2000 Nov 9;11(16):3493-7.

32

123.

Kageyama T, Imura T, Matsuo A, Minato N, Shimohama S.
Distribution of the 4F2 light chain, LAT1, in the mouse brain.
Neuroreport. 2000 Nov 27;11(17):3663-6.

124.

Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S,
Smith MA, Perry G.
Protein disulfide isomerase in Alzheimer disease.
Antioxid Redox Signal. 2000 Fall; 2(3):485-9.

125.

Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ.
Bip/GRP78-induced production of cytokines and uptake of amyloid-beta (1-42) peptide in
microglia.
Biochem Biophys Res Commun. 2001 Feb 16;281(1):6-10.

126.

Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S.
N-methyl -D-aspartate receptor-mediated mitochondrial Ca 2+ overload in acute excitotoxic motor
neuron death: a mechanism distinct from chronic neurotoxicity after Ca2+ influx.
J Neurosci Res. 2001 Mar 1;63(5):377-87.

127.

Kitamura Y, Sanada H, Kakimura J, Ishida Y, Shimohama S, Taniguchi T.
Decrease of tyrosine hydroxylase-, α-synuclein-and parkin-expressing neurons in the substantia
nigra of MPTP-treater C57BL/6N mice.
Biogenic Amines 2001;16: 127-136.

128.

Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T.
Alpha-synuclein protein is not scavenged in neuronal loss induced by kainic acid or focal
ischemia.
Brain Res. 2001 Apr 13;898(1):181-5.

129.

Kageyama T, Shimohama S, Kawamata J.
Coexistence of 2 different type I repeats.
Arch Neurol. 2001 Jun;58(6):1022.

130.

Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A.
Protective effects of 1 alpha, 25-(OH)２D３ against the neurotoxicity of glutamate and reactive
oxygen species in mesencephalic culture.
Neuropharmacology. 2001 May;40(6):761-71.
33

131.

Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A.
alpha 7 nicotinic receptor transduces signals to phosphatidylinositol 3-kinase to block A betaamyloid-induced neurotoxicity.
J Biol Chem. 2001 Apr 27;276(17):13541-6.

132.

Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A.
Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons.
J Neurosci Res. 2001 Jun 1;64(5):466-75.

133.

Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters
HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G,
Smith MA.
Mitochondrial abnormalities in Alzheimer's disease.
J Neurosci. 2001 May 1;21(9):3017-23.

134.

Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T,
Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA.
Oxidative damage is the earliest event in Alzheimer disease.
J Neuropathol Exp Neurol. 2001 Aug;60(8):759-67.

135.

Oeda T, Shimohama S, Kitagawa N, Kohno R, Imura T, Shibasaki H, Ishii N.
Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related
mutant SOD1 in transgenic Caenorhabditis elegans.
Hum Mol Genet. 2001 Sep 15;10(19):2013-23.

136.

Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA.
Activation of MKK6, an upstream activator of p38, in Alzheimer's disease.
J Neurochem. 2001 Oct;79(2):311-8.

137.

Tanino H, Kusuda T, Nagasawa K, Shimohama S, Fujimoto S.
Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia.
Biol Pharm Bull. 2001 Nov;24(11):1241-5.

138.

Shimohama S, Tanino H, Fujimoto S.
Differential subcellular localization of caspase family proteins in the adult rat brain.
Neurosci Lett. 2001 Nov 27;315(3):125-8.
34

139.

Shimohama S, Tanino H, Fujimoto S.
Differential expression of rat brain caspase family proteins during development and aging.
Biochem Biophys Res Commun. 2001 Dec21; 289(5):1063-6.

140.

Yamamoto K, Hashimoto K, Nakano M, Shimohama S, Kato N.
A distinct form of calcium release down-regulates membrane excitability in neocortical pyramidalcells.
Neuroscience. 2002;109(4):665-76.

141.

Yamamoto K, Nakano M, Hashimoto K, Shimohama S, Kato N.
Emergence of a functional coupling between inositol-1,4,5-trisphosphate receptors and calcium
channels in developing neocortical neurons.
Neuroscience. 2002;109(4):677-85.

142.

Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM,
Smith MA.
Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy
bodies in humans.
Neurosci Lett. 2002 Feb 8;319(1):25-8.

143.

Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski
MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G.
High molecular weight neurofilament proteins are physiological substrates of adduction by thelipid peroxidation product hydroxynonenal.
J Biol Chem. 2002 Feb 15;277(7):4644-8.

144.

Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H,
Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, Kaneko S, Akaike A.
Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum.
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3288-93.

145.

Kakimura J, Kitamura Y, Takata K, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y,
Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S.
Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins.
FASEB J. 2002 Apr;16(6):601-3.

35

146.

Kawamata J, Shimohama S.
Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors
with sporadic Alzheimer's disease.
J Alzheimers Dis. 2002 Apr;4(2):71-6.

147.

Sawada H, Ibi M, Kihara T, Honda K, Nakamizo T, Kanki R, Nakanishi M, Sakka N, Akaike A,
Shimohama S.
Estradiol protects dopaminergic neurons in a MPP+ Parkinson's disease model.
Neuropharmacology. 2002 Jun;42(8):1056-64.

148.

Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A.
Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinasecascade.
J Neurosci Res. 2002 Nov 1;70(3):274-82.

149.

Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S.
Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspasepathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Neurosci Lett. 2002 Nov 15;333(1):25-8.

150.

Tsuji T, Shiozaki A, Kohno R, Yoshizato K, Shimohama S.
Proteomic profiling and neurodegeneration in Alzheimer's disease.
Neurochem Res. 2002 Oct;27(10):1245-53.

151.

Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA,
Perry G, Shimohama S.
Possible involvement of ER chaperone Grp78 on reduced formation of amyloid-beta deposits.
Ann N Y Acad Sci. 2002 Nov; 977:327-32.

152.

Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA,
Perry G, Shimohama S.
Possible protective mechanisms of heme oxygenase-1 in the brain.
Ann N Y Acad Sci. 2002 Nov; 977:501-6.

36

153.

Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H,
Shibasaki H, Akaike A, Shimohama S.
Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons.
J Neurosci Res. 2003 Feb 15;71(4):485-95.

154.

Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T,
Tsukahara T, Akaike A, Shimohama S.
Hyperbilirubinemia protects against focal ischemia in rats.
J Neurosci Res. 2003 Feb 15;71(4):544-50.

155.

Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G,
Shimohama S.
Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis.
Biochem Biophys Res Commun. 2003 Feb 14;301(3):699-703.

156.

Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishii N.
The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic
activities.
J Biol Chem. 2003 Apr 4;278(14):12130-4.

157.

Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H,
Takenawa T, Shimohama S.
Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE)
and rac1 in the phagocytosis of amyloid-beta (1-42) in rat microglia.
J Pharmacol Sci. 2003 Jun;92(2):115-23.

158.

Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shibasaki H, Shimohama S.
Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitationof Wnt signaling.
J Neurosci Res. 2003 Jul 15;73(2):166-75.

159.

Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A.
Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone.
Neuroreport. 2003 Dec 19;14(18):2425-8.

37

160.

Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H,
Takenawa T, Shimohama S.
Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting
in Alzheimer's disease.
Neurosci Lett. 2003 Aug 7;346(3):149-152.

161.

Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H,
Shimohama S.
Differences in rotational asymmetry in rats caused by single intranigral injections of
6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone.
Biogenic Amines 2003; 17:281-291.

162.

Kitamura Y, Inden M, Sanada H, Takata K, Taniguchi T, Shimohama S, Orii H, Mochii M, Agata
K, Watanabe K.
Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm
model.
J Pharmacol Sci. 2003 Jun;92(2):137-42.

163.

Takata K, Kitamura Y, Umeki M, Tsuchiya D, Kakimura J, Taniguchi T, Gebicke-Haerter PJ,
Shimohama S.
Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14
prostaglandin J2-sensitive microglial activation.
J Pharmacol Sci. 2003 Apr;91(4): 330-3.

164.

Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S.
Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat
hippocampus in vivo.
Neurosci Lett. 2003 Jun 26;344(2):87-90.

165.

Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H,
Shimohama S.
Presenilin 1 is involved in maturation and trafficking of N-cadherin to the plasma membrane.
J Neurosci Res. 2003 Oct 15;74(2):184-91.

38

166.

Nagasawa K, Tanino H, Shimohama S, Fujimoto S.
Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heartand brain.
Life Sci. 2003 Aug 1;73(11): 1453-62.

167.

Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y.
Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists.
Neurochem Res. 2003 Jul;28(7): 1035-40.

168.

Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S,
Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA.
Neuroprotective Properties of Bcl-w in Alzheimer Disease.
J. Neurochem.2004. 89,1233-1240.

169.

Shiozaki A, Tsuji T, Kohno R, Kawamata J, Uemura K, Teraoka H, Shimohama S.
Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentiallyextracted protein preparation.
J Alzheimers Dis. 2004 Jun;6(3):257-68.

170.

Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa
K, Sibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S.
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alphasynuclein inclusions.
J Biol Chem. 2004 Mar 12;279(11):10710-9.

171.

Kanki R, Nakamizo T, Yamashita H, Kihara T, Sawada H, Uemura K, Kawamata J, Shibasaki H,
Akaike A, Shimohama S.
Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat
spinal motor neurons.
Brain Res. 2004 Jul 23;1015 (1-2):73-81.

172.

Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S.
BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in
glioma cell line.
Biochem Biophys Res Commun. 2004 May 21;318(1):113-8.

39

173.

Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S.
Possible involvement of group I mGluRs in neuroprotective effect of theanine.
Biochem Biophys Res Commun. 2004 Jul 16;320(1):116-22.

174.

Nagasawa K, Nishida K, Nagai K, Shimohama S, Fujimoto S.
Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons
treated with N-methyl -D-aspartate and peroxynitrite.
Neurosci Lett. 2004 Sep 2;367(2):246-9.

175.

Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S.
High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta
neurotoxicity.
J Neurosci Res. 2004 Dec 15;78(6):880-91.

176.

Inden M, Kim D, Gu Y, Kitamura Y, Kondo J, Tsuchiya D, Taniguchi T, Shimohama S,
Akaike A, Sumi S, Inoue K.
Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplantedwith mouse embryonic stem cell-derived neurons.
J Pharmacol Sci. 2004 Sep;96(1):53-64.

177.

Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S.
Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity.
Biochem Biophys Res Commun. 2004 Dec 17;325(3):976-82.

178.

Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T,
Shimohama S.
Cocaine and phenylephrine eye drop test for Parkinson disease.
JAMA. 2005 Feb 23;293(8):932-4.

179.

Honda K, Smith MA, Zhu X, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL,
Siedlak SL, Fujioka H, Liu Q, Moreira PI, Miller FP, Nunomura A, Shimohama S, Perry G.
Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron.
J Biol Chem. 2005 Jun 3;280(22):20978-86.

180.

Nakamizo T, Kawamata J, Yamashita H, Kanki R, Kihara T, Sawada H, Akaike A, Shimohama S.
Stimulation of nicotinic acetylcholine receptors protects motor neurons.
Biochem Biophys Res Commun. 2005 May 20;330(4):1285-9.
40

181.

Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K,
Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak
SL, Harris PL, Sayre LM, Perry G.
Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations.
Free Radic Biol Med. 2005 Mar 15;38(6):746-54.

182.

Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A.
P-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous ironaccelerates the conversion of p-quinone into melanin extracellularly.
J Neurosci Res. 2005 Mar 15;79(6):849-60

183.

Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S.
Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons inhemiparkinsonian rats.
J Pharmacol Sci. 2005 Feb;97(2):203-11.

184.

Kitamura Y, Yanagisawa D, Inden M, Takata K, Tsuchiya D, Kawasaki T, Taniguchi T,
Shimohama S.
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular
injection of microglia.
J Pharmacol Sci. 2005 Feb;97(2):289-93.

185.

Kume T, Kawai Y, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S,
Sugimoto H, Akaike A.
Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor
neurons.
Neurosci Lett. 2005 Aug 5;383(3):199-202.

186.

Inden M, Kim DH, Qi M, Kitamura Y, Yanagisawa D, Nishimura K, Tsuchiya D, Takata K,
Hayashi K, Taniguchi T, Yoshimoto K, Shimohama S, Sumi S, Inoue K.
Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic
nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats.
Neurosci Lett. 2005 Oct 28;387(3):151-6.

41

187.

Izumi Y, Sawada H, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A.
Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides
protection in SH-SY5Y cells.
J Neurosci Res. 2005 Oct 1;82(1):126-37.

188.

Inden M, Kitamura Y, Kondo J, Hayashi K, Yanagida T, Takata K, Tsuchiya D, Yanagisawa D,
Nishimura K, Taniguchi T, Shimohama S, Sugimoto H, Akaike A.
Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and druginduced rotational asymmetry in hemi-parkinsonian rats.
J Neurochem. 2005 Nov;95(4):950-61. Epub 2005 Aug 31.

189.

Yamamoto K, Sakagami Y, Sugiura S, Inokuchi K, Shimohama S, Kato N.
Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex
pyramidal cells.
Eur J Neurosci. 2005 Sep;22(6):1338-48.

190.

Nagasawa K, Akagi J, Koma M, Kakuda T, Nagai K, Shimohama S, Fujimoto S.
Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells.
Life Sci. 2006 May 30;79(1):89-97.

191.

Akatsu H, Yamagata HD, Kawamata J, Kamino K, Takeda M, Yamamoto T, Miki T, Tooyama I,
Shimohama S, Kosaka K.
Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy
bodies in Japan.
Dement Geriatr Cogn Disord. 2006; 22(3): 216-22. Epub 2006 Aug 7.

192.

Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Ninomiya H, Sugimoto H, Kinoshita A,
Shimohama S.
Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.
Neurosci Lett. 2006 Jul 24;402(3):278-83.

193.

Tsuchiya D, Kitamura Y, Takata K, Sugisaki T, Taniguchi T, Uemura K, Miki H, Takenawa T,
Shimohama S.
Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP
family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex
and hippocampus.
Neurosci Res. 2006 Dec;56(4):459-69.
42

194.

Yanagisawa D, Qi M, Kim DH, Kitamura Y, Inden M, Tsuchiya D, Takata K, Taniguchi T,
Yoshimoto K, Shimohama S, Akaike A, Sumi S, Inoue K.
Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantationof mouse embryonic stem cells.
Neurosci Lett. 2006 Oct 16;407(1):74-9.

195.

Inden M, Taira T, Kitamura Y, Yanagida T, Tsuchiya D, Takata K, Yanagisawa D, Nishimura K,
Taniguchi T, Kiso Y, Yoshimoto K, Agatsuma T, Koide-Yoshida S, Iguchi-Ariga SM, Shimohama
S, Ariga H.
PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease
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Neurobiol Dis. 2006 Oct;24(1):144-58.

196.

Uemura K, Kihara T, Kuzuya A, Okawa K, Nishimoto T, Bito H, Ninomiya H, Sugimoto H,
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Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin.
Biochem Biophys Res Commun. 2006 Jul 7;345(3):951-8.

197.

Nishimura K, Kitamura Y, Inoue T, Umesono Y, Sano S, Yoshimoto K, Inden M, Takata K,
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Reconstruction of dopaminergic neural network and locomotion function in planarianregenerates.
Dev Neurobiol. 2007 Jul;67(8):1059-78.

198.

Inden M, Kitamura Y, Takeuchi H, Yanagida T, Takata K, Kobayashi Y, Taniguchi T, Yoshimoto
K, Kaneko M, Okuma Y, Taira T, Ariga H, Shimohama S.
Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral
administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.
J Neurochem. 2007 Jun;101(6):1491-1504.

199.

Yamashita H, Kawamata J, Okawa K, Kanki R, Nakamizo T, Hatayama T, Yamanaka K,
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Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide
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J Neurochem. 2007 Sep;102(5):1497-1505.

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Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S, Kinoshita A.
GSK3beta activity modifies the localization and function of presenilin 1.
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201.

Uemura K, Kuzuya A, Aoyagi N, Ando K, Shimozono Y, Ninomiya H, Shimohama S, Kinoshita A.
Amyloid beta inhibits ectodomain shedding of N-cadherin via down-regulation of cell-surface
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Neuroscience. 2007 Mar 2;145(1):5-10.

202.

Takata K, Kitamura Y, Yanagisawa D, Morikawa S, Morita M, Inubushi T, Tsuchiya D, Chishiro
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203.

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Eur J Pharmacol. 2007 Feb 28;557(2-3):132-40.

204.

Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A.
Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress:
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J Biol Chem. 2007 Feb 16;282(7):4364-72.

205.

Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Uemura K, Miki H, Takenawa T, Shimohama S.
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J Pharmacol Sci. 2006 Nov;102(3):354-8.

206.

Kuzuya A, Uemura K, Kitagawa N, Aoyagi N, Kihara T, Ninomiya H, Ishiura S, Takahashi R,
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Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme
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J Neurosci Res. 2007 Jan;85(1):153-65.

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Yanagida T, Takeuchi H, Kitamura Y, Takata K, Minamino H, Shibaike T, Tsushima J, Kishimoto
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208.

Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y.
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209.

Takeuchi H, Yanagida T, Inden M, Takata K, Kitamura Y, Yamakawa K, Sawada H, Izumi Y,
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Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced
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J Neurosci Res. 2009 Feb;87(2):576-85.

210.

Atsuta N, Watanabe H, Ito M, Tanaka F, Tamakoshi A, Nakano I, Aoki M, Tsuji S, Yuasa T,
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211.

Takata K, Kitamura Y, Nakata Y, Matsuoka Y, Tomimoto H, Taniguchi T, Shimohama S.
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212.

Sawada H, Oeda T, Yamamoto K, Kitagawa N, Mizuta E, Hosokawa R, Ohba M, Nishio R,
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213.

Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T,
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Nunomura A, Tamaoki T, Tanaka K, Motohashi N, Nakamura M, Hayashi T, Yamaguchi H,
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Neurobiol Dis. 2010 Mar; 37(3): 731-7.

215.

Aoyagi N, Uemura K, Kuzuya A, Kihara T, Kawamata J, Shimohama S, Kinoshita A,
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PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting theproteasome activity.
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216.

Yamakawa K, Izumi Y, Takeuchi H, Yamamoto N, Kume T, Akaike A, Takahashi R, Shimohama
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217.

Hisahara S, Shimohama S.
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218.

Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K,
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N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production.
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219.

Takata K, Kitamura Y, Saeki M, Terada M, Kagitani S, Kitamura R, Fujikawa Y, Maelicke A,
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220.

Shen H, Kihara T, Hongo H, Wu X, Kem WR, Shimohama S, Akaike A, Niidome T, Sugimoto H.
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Br J Pharmacol. 2010;161(1):127-39. Erratum in: Br J Pharmacol. 2010 Nov;161(5):1200.
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Tsuda E, Imai T, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomura M,
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Clin Neurophysiol. 2010 Jul;121(7):1051-8.

222.

Hozuki T, Imai T, Tsuda E, Matsumura A, Yamamoto D, Toyoshima T, Suzuki S, Yamauchi R,
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Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy
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223.

Matsushita T, Kibayashi T, Katayama T, Yamashita Y, Suzuki S, Kawamata J, Honmou O,
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224.

Ando K, Uemura K, Kuzuya A, Maesako M, Asada-Utsugi M, Kubota M, Aoyagi N, Yoshioka K,
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N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper
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225.

Okamoto Y, Shirakashi Y, Ihara M, Urushitani M, Oono M, Kawamoto Y, Yamashita H,
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226.

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Imai T, Tsuda E, Toyoshima T, Yoshikawa H, Motomura M, Shimohama S.
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228.

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Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid
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Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M,
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231.

Imai T, Tsuda E, Hozuki T, Yamauchi R, Saitoh M, Hisahara S, Yoshikawa H, Motomura M,
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232.

Koike H, Hashimoto R, Tomita M, Kawagashira Y, Iijima M, Koyano S, Momoo T, Yuasa H,
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Maesako M, Uemura K, Kubota M, Kuzuya A, Sasaki K, Asada M, Watanabe K, Hayashida N,
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234.

Imai T, Tsuda E, Hozuki T, Yoshikawa H, Yamauchi R, Saitoh M, Hisahara S, Motomura M,
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235.

Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, Ariga H, Honmou O,
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236.

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Noda Y, Asada M, Kubota M, Maesako M, Watanabe K, Uemura M, Kihara T, Shimohama S,
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Suzuki S, Kawamata J, Matsushita T, Matsumura A, Hisahara S, Takata K, Kitamura Y, Kem W,
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Yamauchi R, Imai T, Tsuda E, Hozuki T, Yamamoto D, Shimohama S.
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Shimamoto K, Ando K, Fujita T, Hasebe N, Higaki J, Horiuchi M, Imai Y, Imaizumi T, Ishimitsu
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The Japanese society of hypertension guidelines for the management of hypertension (JSH 2014).
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Maesako M, Uemura M, Tashiro Y, Sasaki K, Watanabe K, Noda Y, Ueda K, Asada-Utsugi M,
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Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgGabnormality in multiple sclerosis.
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Suzuki S, Kawamata J, Iwahara N, Matsumura A, Hisahara S, Matsushita T, Sasaki M,
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Jingami N, Asada-Utsugi M, Uemura K, Noto R, Takahashi M, Ozaki A, Kihara T, Kageyama T,
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Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile
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247.

Matsumura A, Suzuki S, Iwahara N, Hisahara S, Kawamata J, Suzuki H, Yamauchi A, Takata K,
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Watanabe K, Uemura K, Asada M, Maesako M, Akiyama H, Shimohama S, Takahashi R,
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Miyazaki Y, Niino M, Kanazawa I, Suzuki M, Mizuno M, Hisahara S, Fukazawa T, Takahashi E,
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Saito Y, Akazawa-Ogawa Y, Matsumura A, Saigoh K, Itoh S, Sutou K, Kobayashi M, Mita Y,
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A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3
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Inden M, Takata K, Yanagisawa D, Ashihara E, Tooyama I, Shimohama S, Kitamura Y.
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Clinical and radiological characteristics of intracranial artery dissection using recently proposed
diagnostic criteria.
J Stroke Cerebrovasc Dis. 2019 Mar 18 ;28(6):1691-1702

54

269.

Fujikura M, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T,
Manabe T, Matsushita T, Suzuki S, Shimohama S.
CD14 and toll-like receptor 4 promote fibrillar Aβ42 uptake by microglia through a clathrinmediated pathway.
J Alzheimers Dis. 2019;68(1):323-337.

270.

Muppidi S, Utsugisawa K, Benatar M, Murai H, Barohn RJ, Illa I, Jacob S, Vissing J, Burns TM,
Kissel JT, Nowak RJ, Andersen H, Casasnovas C, de Bleecker JL, Vu TH, Mantegazza R, O'Brien
FL, Wang JJ, Fujita KP, Howard JF Jr; Regain Study Group.
Long-term safety and efficacy of eculizumab in generalized myasthenia gravis.
Muscle Nerve. 2019 Jul;60(1):14-24.

271.

Manabe T, Matsumura A, Yokokawa K, Saito T, Fujikura M, Iwahara N, Matsushita T, Suzuki S,
Hisahara S, Kawamata J, Suzuki H, Emoto MC, Fujii HG, Shimohama S.
Evaluation of mitochondrial oxidative stress in the brain of a transgenic mouse model of
Alzheimer's disease by in vitro electron paramagnetic resonance spectroscopy.
J Alzheimers Dis. 2019; 67(3):1079-1087.

272.

Fujiwara D, Iwahara N, Sebori R, Hosoda R, Shimohama S, Kuno A, Horio Y.
SIRT1 deficiencyinterferes with membrane resealing after cell membrane injury.
PLoS One. 2019 Jun 26;14(6): e0218329.

273.

Saito T, Hisahara S, Iwahara N, Emoto MC, Yokokawa K, Suzuki H, Manabe T, Matsumura A,
Suzuki S, Matsushita T, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S.
Early administration of galantamine from preplaque phase suppresses oxidative stress andimproves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease.
Free Radic Biol Med. 2019 Sep 16; 145:20-32.

274.

Yokokawa K, Iwahara N, Hisahara S, Emoto MC, Saito T, Suzuki H, Manabe T, Matsumura A,
Matsushita T, Suzuki S, Kawamata J, Sato-Akaba H, Fujii HG, Shimohama S.
Transplantation of mesenchymal stem cells improves amyloid-β pathology through modifying
microglial function and suppressing oxidative stress.
J Alzheimers Dis. 2019;72(3):867-884.

55

275.

Murai H, Uzawa A, Suzuki Y, Imai T, Shiraishi H, Suzuki H, Okumura M, O'Brien F, Wang JJ,
Fujita KP, Utsugisawa K; REGAIN Study Group.
Long-term efficacy and safety of eculizumab in Japanese patients with generalized myasthenia
gravis: A subgroup analysis of the REGAIN open-label extension study.
J Neurol Sci. 2019 Dec 15; 407:116419.

276.

Vissing J, Jacob S, Fujita KP, O'Brien F, Howard JF; REGAIN study group.
'Minimal symptom expression' in patients with acetylcholine receptor antibody-positiverefractory generalized myasthenia gravis treated with eculizumab.
J Neurol. 2020 Jul:267(7)1991-2001.

277.

Mantegazza R, O'Brien FL, Yountz M, Howard JF Jr; REGAIN study group.
Consistent improvement with eculizumab across muscle groups in myasthenia gravis.
Ann Clin Transl Neurol. 2020 Jul 22; 7(8): 1327-39.

278.

Kuroda E, Nishimura K, Kawaniishi S, Sueyoshi M, Ueno F, Toji Y, Abo N, Konishi T, Harada, K
Satake S, Shima C, Toda Y, Kitamura Y, Shimohama S, Ashihara E, Takata K.
Mouse bone marrow-derived Microglia-like cells secrete transforming grouth factor-β1 andpromote microglial Aβ phagocytosis and reductio of brain Aβ.
Neuroscience. 2020 July 1; 438:217-228.

279.

Watanabe M, Nakamura Y, Sato S, Niino M, Fukaura H, Tanaka M, Ochi H, Kanda T,
Takeshita Y, Yokota T, Nishida Y, Matsui M, Nagayama S, Kusunoki S, Miyamoto K, Mizuno M,
Kawachi I, Saji E, Ohashi T, Shimohama S, Hisahara S, Nishiyama K, Takahiro I, Nakatsuji Y,
Okuno T, Ochi K, Suzumura A, Yamamoto K, Kawano Y, Tsuji S, Hirata M, Sakate R, Kimura T,
Shimizu Y, Nagaishi A, Okada K, Hayashi F, Sakoda A, Masaki K, Shinoda K, Isobe N,
Matsuhsita T, Kira J.
HLA genotype-clinical phenotype correlations in multiple sclerosis and neuromyelitis optica
spectrum disorders based on Japan MS/NMOSD Biobank data.
Sci Rep.2020 in press

280.

Hisahara S, Nishiyama A, Tsuda E, Suzuki S, Matsumura A, Ishikawa A, Sakurai A, Motoike N. I,
Aoki M, Aoki Y, Shimohama S.
Possible somatic mosaicism of novel FUS variant in familial amyotrophic lateral sclerosis.
Neurology-Genetics 2020 in press

56

Ⅱ. 欧文総説（Rewiew article）
1.

Shimohama S, Ninomiya H, Saitoh T, Terry RD, Fukunaga R, Taniguchi T, Fujiwara M, Kimura
J, Kameyama M.
Changes in signal transduction in Alzheimer's disease.
J Neural Transm Suppl. 1990; 30:69-78.

2.

Shimohama S, Fujimoto S, Tresser N, Richey P, Perry G, Whitehouse PJ, Homma Y, Takenawa T,
Taniguchi T, Suenaga T, Kimura J.
Aberrant phosphoinositide metabolism in Alzheimer's disease.
Ann N Y Acad Sci. 1993 Sep 24; 695:46-9.

3.

Shimohama S, Matsushima H.
Signal transduction mechanisms in Alzheimer disease.
Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22.

4.

Shimohama S.
Signal transduction mechanisms in Alzheimer disease.
Parkinson / Alzheimer Digest 1996; 3:21-22.

5.

Shimohama S.
Altered calcium homeostasis in Alzheimer,s disease.
Drug News & Perspectives 1997;10: 596-603.

6.

Shimohama S.
Phospholipase C et maladie d Alzheimer,s disease.
Alzheimer Actualities: Lettre d,information sur les desordres cognitifs lies a l,age. Foundation
Ipsen 1999; 145: 6-10.

7.

Sawada H, Shimohama S.
MPP+ and glutamate in the degeneration of nigral dopaminergic neurons.
Parkinsonism & Related Disorders 1999;5:209-215.

8.

Kitamura Y, Taniguchi T, Shimohama S.
Apoptotic cell death in neurons and glial cells: Implications for Alzheimer’s Disease.
Jpn J pharmacol.1999 Nov;79:1-5.
57

9.

Kitamura Y, Shimohama S, Akaike A, Taniguchi T.
The parkinsonian models: invertebrates to mammals.
Jpn J Pharmacol. 2000 Nov;84(3):237-43.

10.

Sawada H, Shimohama S.
Neuroprotective effects of estradiol in mesencephalic dopaminergic neurons.
Neurosci Biobehav Rev. 2000 Jan;24(1):143-7.

11.

Shimohama S.
Apoptosis in Alzheimer's disease--an update.
Apoptosis. 2000 Feb;5(1):9-16.

12.

Kihara T, Shimohama S.
Nicotinic agonists protect neurons from glutamate and β-amyloid neurotoxicity.
Research and Practice in Alzheimer,s Disease and Other Dementias 2000;3: 217-221.

13.

Urushitani M, Shimohama S.
The role of nitric oxide in amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Other Motor Neuron Disord. 2001 Jun;2(2):71-81.

14.

Shimohama S, Kihara T.
Nicotinic receptor-mediated protection against -amyloid neurotoxicity.
Biol Psychiatry. 2001 Feb 1;49(3):233-9.

15.

Tsuji T, Shimohama S.
Analysis of the proteomic profiling of brain tissue in Alzheimer,s disease.
Disease Markers 2001;17: 247-257.

16.

Perry G, Taddeo MA, Nunomura A, Zhu X, Zenteno-Savin T, Drew KL, Shimohama S, Avila J,
Castellani RJ, Smith MA.
Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative
diseases: beyond damage and response.
Comp Biochem Physiol C Toxicol Pharmacol. 2002 Dec;133(4):507-13.

58

17.

Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Aliev G, Avila J, Wataya T, Shimohama S,
Atwood CS, Smith MA.
Reactive oxygen: its sources and significance in Alzheimer disease.
J Neural Transm Suppl. 2002;(62):69-75.

18.

Tsuji T, Shimohama S.
Protein degradation in Alzheimer's disease and aging of the brain.
Prog Mol Subcell Biol. 2002;29:43-60.

19.

Kitamura Y, Kakimura J, Takata K, Taniguchi T, Shimohama S.
Regulation of amyloid-β-clearance by stress proteins.
Recent Res Devel Biophys Biochem. 2002; 89-98.

20.

Raina AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA.
Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Apr;27(2):251-4.

21.

Shimohama S, Sawada H, Kitamura Y, Taniguchi T.
Disease model: Parkinson,s disease.
Trends Mol Med. 2003 Aug;9(8):360-5.

22.

Sawada H, Shimohama S.
Estrogens and Parkinson,s deisease: Novel approach for neuroprotection.
Endocrine. 2003; 21:77-80.

23.

Raina AK, Zhu X, Shimohama S, Perry G, Smith MA.
Tipping the apoptotic balance in Alzheimer disease: The abortosis concept.
Cell Biochemistry and Biophysics. 2003;39: 249- 255.

24.

Perry G, Avila J, Casadesus G, Nunomura A, Tabaton M, Cash A, Aliev G, Wataya T, Shimohama
S, Drew K, Atwood C, Smith M.
The role of oxidative stress in the pathogenesis of Alzheimer’s disease.
Rev Chil Neuro-Psiquiat 2003; 41(supl 2): 47-52.

25.

Kihara T, Shimohama S.
Alzheimer's disease and acetylcholine receptors.
Acta Neurobiol Exp (Wars). 2004;64(1):99-105.
59

26.

Uemura K, Kuzuya A, Shimohama S.
Protein trafficking and Alzheimer's disease.
Curr Alzheimer Res. 2004 Feb;1(1):1-10.

27.

Takata K, Kitamura Y, Tsuchiya D, Taniguchi T, Shimohama S.
Microglial activation around amyloid-β deposits in mouse and rat models.
International Congress Series. 2004; 1260: 265-269.

28.

Tsuchiya D, Kitamura Y, Takata K, Taniguchi T, Shmohama S.
Clearance of amyloid-β in microglial culture model.
International Congress Series. 2004; 1260:271-274.

29.

Honda K, Shimohama S, Smith MA, Perry G.
Role of redox-active iron in Alzheimer’s disease.
Current medical literature. Neurology 2004, Vol.20, No2:25-30.

30.

Tsuji T, Shiozaki A, Shimohama S.
The application of proteomics in Neurology.
Current Proteomics. 2005;43:685-694.

31.

Shimohama S.
Nicotinic receptor-mediated neuroprotection in neurodegenerative disease models. (Current
topics, functional changes induced by long-term stimulation of nicotinic acetylcholine receptors)
Pharm. Bull. 2009: 32 (3): 332-336.

32.

Kawamata J, Suzuki S, Shimohama S.
Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models.
Ther Adv Chronic Dis. 2011 May;2(3):197-208.

33.

Kawamata J, Shimohama S.
Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of
Alzheimer's and Parkinson's diseases.
J Alzheimers Dis. 2011;24 Suppl 2:95-109.

34.

Hisahara S, Shimohama S.
Dopamine receptors and Parkinson's disease.
Int J Med Chem. 2011:403039.
60

35.

Kawamata J, Suzuki S, Shimohama S.
α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease.
Curr Drug Targets. 2012 May;13(5):623-30.

61

Ⅲ. 著書（Monograph）
1.

Shimohama S, Taniguchi T, Fujiwara M, Kameyama M.
Acetylcholine receptors in Alzheimer-type dementia.
In Yoshida H.editor. Recent Research on Neurotransmitter Receptors.Tokyo: Excerpta
Medica;1986. pp. 2-11.

2.

Shimohama S, Kunugi YU, Terai K, Saitoh T, Taniguchi T, Kimura J.
Expression of protein kinase C isozymes in primary neuronal cultures.
In Nishizuka Y, editor. Advances in Second Messenger and Phosphoprotein Research. New York:
Raven Press ;1990. pp635-636.

3.

Shimohama S, Ninomiya H, Kameyama M.
Reduced N-methyl -D-aspartate (NMDA) receptor-ion channel complex in Alzheimer’s disease
frontal cortex.
In Nagatsu T, Yoshida M, editors. Alzheimer’s and Parkinson’s Disease. London: Plenum Pub.
Co;1991. pp575-578.

4.

Ninomiya H, Fukunaga R, Taniguchi T, Fujiwara M, Shimohama S, Kameyama M.
Decrease number of NMDA receptors in the brains of Alzheimer type dementia patients.
In Kameyama T, Nabeshima T, Domino EF, editors. NMDA Receptor Related Agents:
Biochemistry, Pharmacology and Behavior. Ann Arbor: NPP Books;1991. pp401-408.

5.

Shimohama S, Ninomiya H.
N-methyl -D-aspartate (NMDA) receptor-ion channel complex in Alzheimer brains.
In Kameyama M, editor. β-Amyloid Precursor Proteins and Neurotransmitter Function. Tokyo:
Excerpta Medica;1991. pp94-105.

6.

Shimohama S, Homma Y, Fujimoto S, Suenaga T, Taniguchi T, Araki W, YamaokaY, Matsushima
H, Takenawa T, Kimura J.
Aberrant accumulation of phospholipase C in Alzheimer brains.
In Nicolini M, Zatta PF, Corain B, editors. Advances in the Biosciences Vol. 87: Alzheime’,sDisease and Related Disorders. New York: Pergamon Press Ltd;1993. pp207-209.

62

7.

Shimohama S, Fisher J, Gage FH.
Intracerebral grafting of genetically modified cells: Application to a rat model of Parkinson’s
disease.
In Narabayashi H, Nagatsu T, Yanagisawa N, Mizuno Y, editors. Parkinson’s Disease: From Basic
Research to Treatment. Advances in Neurology Vol. 60, New York: Raven Press;1993. pp744-748.

8.

Kawamata J, Shimohama S, Hasegawa H, Imura T, Kimura J, Ueda K.
Deletion and point mutations in superoxide dismutase-1 gene in amyotrophic lateral sclerosis.
In Nakano I, Hirano A, editors. Amyotrophic Lateral Sclerosis-Progress and Perspectives in Basic
Research and Clinical Application. Tokyo: Elsevier;1996. pp 276-280.

9.

Imura T, Shimohama S, Kawamata J, Kimura J, Ueda K.
Polymorphism in NF-H and GPX1 genes in Japanese sporadic and familial ALS.
In Nakano I, Hirano A, editors. Amyotrophic Lateral Sclerosis-Progress and Perspectives in Basic
Research and Clinical Application. Tokyo: Elsevier;1996. pp 296-299.

10.

Kihara T, Shimohama S, Akaike A.
Nicotinic receptor stimulation protects aganst Glutamate- and -amyloid-β-induced cytotoxicity.
In Iqbal K, Swaab DF, Winblad B, Wisniewski HM, editors. Alzheimer’s Disease and Related
Disorders: Etiology, Pathogenesis and Therapeutics. New york: John Wiley & Sons, Ltd;1999.
pp715-722.

11.

Kageyama T, Shimohama S.
TNF-α and dexamethasone suppress L-DOPA transport in the blood brain barrier.
In Suketa Y, Carafoli E, Lazdunski M, Mikoshiba K, Okada Y, Wright EM, editors.
Control and Diseases of Sodium Dependent Transport Proteins and Ion Channels. Tokyo:
Elsevier;2000. pp 401-402.

12.

Kihara T, Shimohama S.
Nicotinic agonists protect neurons from glutamate and β-amyloid neurotoxicity.
In Vellas, B. & Fitten, L. J. editors. Research and practice in alzheimer’s disease.Vol.3.
Paris ; Serdi /springer;2000.pp217-221.

63

13.

Urushitani M, Nakamizo T, Akaike A, Takahashi R, Shimohama S.
Protective effect of cyclic GMP against acute, but not against chronic oxidative injury of spinal
motor neurons.
In Abe K, editor. Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis.
Tokyo: Elsevier;2001. pp325-331.

14.

Perry G, Nunomura A, Friedlich AL, Boswell MV, Brazdil L, Jones PK, Rottkamp CA, Zhu X,
Raina AK, Hirai K, Friedland RP, Shi J, Alev G, Cash A, Russell RL, Wataya T, Shimohama S,
Atwood CS, Smith MA.
Factors controlling oxidative damage in Alzheimer disease: metals andmitochondria.
In Yoshikawa T, Toyokuni S, Yamamoto Y, Naito Y, editors. Free Radicals in Chemistry, Biology
and Medicine. London: OICA International (UK) Limited;2001. pp417- 423.

15.

Honda K, Sawada H, Shimohama S.
Neuroprotective effect of estrogen.
In Pandalai SG, editor. Recent Research Developments in Neurochemistry. Transworld Research
Network Publisher;2001. pp155-166.

16.

Sawada H, Shimohama S.
Neuroprotective effects of estrogen in nigral dopaminergic neurons.
In Handa R.J, Terasawa E, Hayashi S, Kawata M, editors. Neuroplasticity, Development, andSteroid Hormone Action. London: CRC Press LLC; 2002. pp93-99.

17.

Kitamura Y, Kakimura J, Taniguchi T, Shimohama S, Gebicke-Haerter PJ.
Bip/GRP78- inducedmicroglial activation and increase of Aβclearance.
In Mizuno Y, Fisher A, Hanin I, editors. Mapping the Progress of Alzheimer’s and Parkinson’s
Disease. New York: Kluwer Academic/Plenum Publisher;2002. pp235-238.

18.

Raine AK, Sayre LM, Atwood CS, Rottkamp CA, Hochman A, Zhu X, Obrenovich ME,
Shimohama S, Nunomura A, Takeda A, Perry G, Smith MA.
Apoptotic and oxidative indicators in Alzheimer’s disease.
In LeBlanc AC, editors. Neuromethods, Vol. 37: Apoptosis Techniques and Protocols, 2nd Ed.
Totowa: Humana Press, Inc; 2002. pp225-246.

64

19.

Tsuji T, Shimohama S.
Protein degradation in Alzheimer’s disease and aging of the brain.
In Reboud-Ravaux M, editor. Protein Degradation in Health and Disease. Progress in Molecularand Subcelluar Biolology Series 29. France: Springer; 2002. pp43-60.

20.

Raina AK, Rottkamp CA, Zhu X, Ogawa O, Hochman A, Shimohama S, Takedea A, Nunomura
A, Perry G, Smith MA.
Neuronal survival and death in Alzheimer disease.
In Mizuno Y, editor. Mapping the Progress of Alzheimer’s Disease. Kluwer Academic/Plenum
publishers, 2002. pp49-57.

21.

Kihara T, Shimohama S.
Nicotinic receptor stimulation blocks neurotoxicity induced by Amyloid-β via the PI3 kinasecascade.
In Takeda M, editor. Molecular Neurobiology of Alzheimer Disease and Related Disorders.
Basel: Karger Publishers;2004. pp108-122.

22.

Shimohama S.
Nicotinic receptor-mediated neuroprotection and cognitive and behavioural systems: Rationale
for therapy in Alzheimer’s disease.
In Shimohama S, editor. Alzheimer’s disease and nicotinic acetylcholine receptors-neurocognitiveenhancement and neuroprotection. Ecerpta Medica;2007. pp5-6.

23.

Kihara T, Shimohama S.
Nicotinic receptor-mediated protection against neurotoxicity and apoptosis.
In Shimohama S, editor. Alzheimer’s disease and nicotinic acetylcholine receptors-neurocognitiveenhancement and neuroprotection. Ecerpta Medica;2007. pp55-66.

24.

Yamauchi R, Kawamata J, Shimohama S.
Comparative study on application of invasive and non-invasive ventilation to ALS patients inJapan, The USA and Europe.
In Bradley James, Turner and Julie Atkin, editors: Motor Neuron Disease: Causes, Classification
and Treatments. ISBN:978-161470-101-9. 2011 Nova Science publishers, Inc.

65

25.

Hisahara S and Shimohama S.
Animal models of Parkinson’s disease induced by toxins and genetic manipulation.
In Juliana Dushanova.editor. Mechanisms in Parkinson's disease - models and treatments.
chapter 17. INTECH. Inc, 2012. pp 323-350.

26.

Tsuji T, Aoki M, Shimohama S.
The proteome in Neurodegenerative disease.
In imai K, Li Y. F. S, editor: Quantitative proteome analysis:methdos and applications. Pan
Stanford publishing;2013. pp85-119.

27.

Shimohama S, Kawamata J.
Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer’s andParkinson’s disease.
In Akaike A, Shimohama S, Misu Y editors. Nicotinic Acetylcholine Receptor Signaling in
Neuroprotection. Springer;2018. pp137-158.

66

Ⅳ. 欧文症例報告（Case Reports）
1.

Hitomi T, Mezaki T, Tsujii T, Kinoshita M, Tomimoto H, Ikeda A, Shimohama S, Okazaki T,
UchiyamaT, Shibasaki H.
Improvement of central motor conduction after bone marrow transplantation inadrenoleukodystrophy.
J Neurol Neurosurg Psychiatry 2003 ;74:373-375.

2.

Shibasaki H, Hitomi T, Mezaki T, Terai H, Kihara T, Kageyama T, Murase N, Matsuhashi M,
Tomimoto H, Ikeda A, Shimohama S, Ito M, Oka N.
A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis
multiplex.
J Neurol 2004;251:1340-1344.

3.

Hitomi T, Mezaki T, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H.
Long-term effect of bone marrow transplantation in adult-onset adrenoleukodystrophy.
Eur J Neurol 2005; 12:807-810.

4.

Matsumoto R, Ikeda A, Hitomi T, Aoki T, Hanakawa T, Miki Y, Tomimoto H, Shimohama S,
Shibasaki H.
Ictal monoparesis associated with lesions in the primary somatosensory area.
Neurology 2005;65:1476-1478.

5.

Nakaji K, Ikeda A, Oka Y, Tomimoto H, Shimohama S, Kanbayashi T, Shibasaki H.
Hypersomnia caused by isolated angitis of the CNS.
Intern Med 2005;44:883-885.

6.

Ikeda A, Matsui M, Hase Y, Hitomi T, Shibasaki H, Shimohama S.
Burst and slow complexes in nonconvulsive, epileptic status.
Epileptic Disord 2006;8:61-64.

7.

Ihara M, Makino F, Sawada H, Mezaki T, Mizutani K, Nakase H, Matsui M, Tomimoto H,
Shimohama S.
Gluten sensitivity in japanese patients with adult-onset cerebellar ataxia.
Intern Med 2006;45:135-140.
67

8.

Begum T, Ikeda A, Takahashi J, Tomimoto H, Shimohama S, Satow T, Nagamine T, Fukuyama H,
Shibasaki H.
Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults).
Intern Med 2006;45:141-144.

9.

Mitsueda-Ono T, Ikeda A, Noguchi E, Takaya S, Fukuyama H, Shimohama S, Takahashi R.
Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a casereport.
J Neurol Sci. 2006; 247:109-111.

10.

Kihara T, Shimohama S.
Occipital neuralgia evoked by facial herpes zoster infection.
Headache. 2006; 46:1590-1591.

11.

Tsuda E, Imai T, Matsumura A, Hisahara S, Nonaka M, Shiraishi H, Motomura M,
Shimohama S.
Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia.
Intern Med. 2008; 47:445-447.

12.

Tsuda E, Imai T, Hozuki T, Yamamoto D, Harada K, Shimohama S.
Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory
demyelinating polyneuropathy.
Intern Med. 2009;48(22):1985-1987.

13.

Matsumura A, Oda M, Hozuki T, Imai T, Shimohama S.
Dural arteriovenous fistula in a case of dementia with bithalamic MR lesions.
Neurology. 2008;71: 1553.

14.

Kawamata J, Ikeda A, Fujita Y, Usui K, Shimohama S, Takahashi R.
Mutations in LGI1 gene in japanese families with autosomal dominant lateral temporal lobe
epilepsy: the first report from Asian families.
Epilepsia. 2010;51: 690-693.

15.

Hisahara S, Matsushita T, Kitamura M, Mezawa S, Nonaka M, Imai T, Shimohama S.
Long-term clinical and radiological improvement of chronic acquired hepatocerebral
degeneration after obliteration of portosystemic shunt: Report of a case.
J Neurol Sci 2014;346: 303-306.
68

16.

Fujikura M, Hisahara S, Yamamoto D, Suzuki S, Tsuda E, Saito M, Kawamata J, Imai T,
Shimohama S.
Oculopharyngeal muscular dystrophy with marked clinical fluctuations mimicking myasthenia
gravis: A case report.
Neurology and Clinical Neuroscience. 2014; 2: 109–111.

17.

Iwahara N, Hisahara S, Hayashi T, Kawamata J, Shimohama S.
A novel lamin A/C gene mutationcausing spinal muscular atrophy phenotype with cardiac
involvement: report of one case.
BMC Neurol. 2015; 20;15:13.

18.

Hisahara S, Matsushita T, Furuyama H, Tajima G, Shigematsu Y, Imai T, Shimohama S.
A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase
deficiency with exercise-induced rhabdomyolysis.
Tohoku J Exp Med. 2015; 235:305-310.

19.

Hisahara S, Yamada M, Matsuura Y, Tsuda E, Akiyama Y, Saitoh M, Kawamata J, Mikuni N,
Shimohama S.
ANCA-negative granulomatosis with polyangiitis presenting with orbital apexsyndrome andrecurrent pachymeningitis: A case report.
J Neurol Sci. 2016 Sep 15; 368: 175-7.

20.

Yokokawa K, Hisahara S, Matsuura Y, Ikeda K, Tsuda E, Saitoh M, Nakamichi K, Saijo M,
Kamihara Y, Sato T, Kawamata J, Shimohama S.
Progressive multifocal leukoencephalopathy after autologous peripheral blood stem celltransplantation in a patient with multiple myeloma treated with combination therapy.
J Neurol Sci. 2016; 368:304-306.

21.

Kurauchi Y, Tsumoto T, Tokunaga S, Tsurusaki Y, Saito M, Yasaka M, Shimohama S, Okada1 Y.
A case that showed exacerbation of intracranial arterial stenosis in the chronic phase after
percutaneous intracranial stent retriever thrombectomy.
Journal of Neuroendovascular Therapy. 2017; 11:398-402.

22.

Takahashi Y, Mikami T, Suzuki H, Komatsu K, Yamamoto D, Shimohama S, Houkin K, Sugita S,
Hasegawa T, Mikuni N.
Development of moyamoya disease after non-herpetic acute limbicencephalitis: A case report.
J Clin Neurosci. 2018; 53:250-253.
69

23.

Nakamura Y, Miyanaga R, Shizukawa H, Shimohama S.
An anti-PM/Scl-75 antibody-positive Japanese woman who developed inflammatory myopathy.
Intern Med. 2019 jun 7.

24.

Tanemoto M, Hisahara S, Hirose B, Ikeda K, Matsushita T, Suzuki S, Manabe T, Imai T,
Shimohama S.
Severe mononeuritis multiplex due to rheumatoid vasculitis in rheumatoid arthritis in sustained
clinical remission for decades: a case report.
Intern Med. 2020;59: 705-710.

25.

Ohashi I, Wada S, Yoshino F, Kuwashiro T, Matsumoto S, Hotta T, Kang D, Okada Y,
Shimohama S, Yasaka M.
Ischemic stroke with protein S deficiency treated by apixaban.
J Stroke Cerebrovasc Dis. 2020 Jan 13:104608.

26.

Kojima Y, Ikeda K, Matsumura A, Shimohama S, Chang B, Yoshida T, Hamada K, Ito A, Ito T.
Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine
pneumococcal serotype 23A.
Oxf Med Case Reports. 2020 May 6;2020(3): omaa018.

27.

Miyanaga R, Hisahara S, Ohhashi I, Yamamoto D, Matsumura A, Suzuki S, Tanimoto K, Hirakawa
M, Kawamata J, Kato J, Shimohama S.
Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term
Treatment with Proton Pump Inhibitors.
Intern Med. 2020 Nov 1;59(21):2783-2787.

28.

Ikeda K, Hirose B, Yamamoto D, Hisahara S, Shimohama S, Shiraishi H, Motomura M, Imai T.
A case presenting electrophysiological and immunological characteristics of Fisher syndrome andLambert-Eaten myasthenic syndrome.
Muscle Nerve. 2020; :29.

Yano T, Hisahara S, Nagano N, Noto T, Ogawa T, Nishikawa R, Koyama M, Kouzu H, Muranaka A,
Hashimoto A, Shimohama S, Miura T.
Abrupt onset of cardiac tamponade in sarcoidosis: a serious but steroid-responsive complication.
Circ Heart Fail. 2020;

70

30.

Hisahara S, Nishiyama A, Tsuda E, Suzuki S, Matsumura M, Ishikawa A, Sakurai A, Motoike I.N.,
Aoki M, Aoki Y, Shimohama S.
Possible somatic mosaicism of novel FUS variant in familial amyotrophic lateral sclerosis.
Neurology-Genet. 2020;

31.

:

-

Nakamura Y, Uemura T, Kawata Y, Hirose B, Yamauchi R, Shimohama S.
Streptococcus oralis Meningitis with Gingival Bleeding in a Patient: A Case Report and Review of
the Literature.
Intern Med. 2020 Sep 30. doi: 10.2169/internalmedicine.5628-20. Online ahead of print.

32.

Tanemoto M, Hisahara S, Ikeda K, Yokokawa K, Manabe T, Tsuda R, Yamamoto D,
Matsushita T, Matsumura A, Suzuki S, Shimohama S.
A Case of Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with AsymmetricMuscle Weakness and Anti-ganglioside Antibodies.
Internal Medicine.2020;71

Ⅴ．欧文その他（Others）
1.

Shimohama S, Kunugi YU,Tamura H,Taniguchi T, Ninomiya H, Kimura J, Saitoh T.
Differential modulation of protein kinase C isozymes in differentiation of PC12H cells stimulatedby dibutyryl C-AMP.
Society for Neuroscience abstracts COL.116,Oct 1990.

2.

Smith MA, Nonomura A, Sayre LM, Rottkamp CA, Zhu X, Raina AK, Hirai K, Friedlana RP, Shi
J, Aliev G, Wataya T, Shimohama S, Atwood GS, Perry G.
Fundamental role of oxidative stress and stressor in Alzheimer disease.
Dementia 2000. 14:232

3.

Perry G, Nonomura A, Friedlich AL, Boswell MV, Braqzdil L, Jones PK, Rottkamp CA, Zhu X,
Raina AK, Hirai K, Fridland RP, Shi J, Aliev G, Cash A, Russell RL, Wataya T, Shimohama S,
Atwood CS, Smith MA.
Factor controlling oxidative damage in Alzheimer disease: Metals and Mitochondoria.
Society of Free Radical Research International 2000, P57

4.

Perry G, Liu Q, T Wataya, Shimohama S, Nunomura A, Siedlak SL, Sayre LL, Smith MA.
Neurofilament proteins are major targets of oxidative damagae in the nervous system.
Journal of Neuropathology and Experimental Neurology 2002. 61:456

5.

Matsushima M, Yabe I , Sakushima K ,Iwata I , Kanatani Y, Nishimoto N, Matsuoka T, Katayama
T, Uesugi H, Sako K, Takei A , Tamakoshi A , Shimohama S, Sato N, Kikuchi S, Sasaki H.
Epidemiological study of multiple system atrophy. data from HoRC-MSA Project 2014-2019
MOVEMENT DISORDERS Volume: 34 Pages: S109-S109

6.

Matsushima M, Sakushima K, Yabe I, Kanatani Y, Ito Y, Matsuoka T, Katayama T, Uesugi H,
Sako K, Takei A, Shimohama S, Sato N, Kikuchi S, Sasaki H.
Usefulness of a simple symptom assessment scale for multiple system atrophy. data from HoRCMSA Project.
MOVEMENT DISORDERS Volume: 33 Supplement: 2 Pages: S840-S840 Meeting Abstract:1810 Published: OCT 2018

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7.

Nakamura Y, Yamaguchi Y, Koga M, Morita Y, Makita N, Ide T, Wada S (Wada, Shinichi),Shimohama S; Ihara M, Toyoda K.
Clinical and radiological characteristics of intracranial artery dissection using recently proposed
diagnostic criteria.
STROKE Volume: 49 Supplement: 1 Meeting Abstract: WMP68 Published: JAN 2018

8.

Hirose B, Ikeda K, D. Yamamoto D, Shimohama S, Asada Y, T. Imai T.
The impairment of excitation-contraction coupling in icu-acquired weakness.
Journal of the Neurological Sciences 405S (2019) UNSP105154

9.

Yamamoto D, Ikeda D, Hirose B, Asada Y, Shimohama S, Tsuda E, Hozuki T, Yamauchi R,
Imai T.
Electrophysiological evaluation of peripheral neuropathies in hereditary spinocerebellar ataxia.
Journal of the Neurological Sciences 405S (2019)UNSP 104795

10.

Nakamura Y, Kurauchi Y, Sato R, Takahashi A, Komeichi T, Yamauchi R, Shimohama S.
Endovascular thrombectomy and left atrial appendage evaluation for recurrent cerebral
embolism case with atrial fibrillation early after administration of intravenous tissue plasminogenactivatore.
Interdiscip Neurosurg.http://doi.org/10.1016/j.inat.2019.

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