Original Articles
1. Imai M, Hoshi T, Ogawa K. K-ras codon 12 mutation in biliary tract tumors
detected by polymerase chain reaction denaturing gradient gel electrophoresis.
CANCER 1994; 73: 2723-2733.
2. Hoshi T, Imai M, Ogawa K. Frequent K-ras mutations and absence of P 53
mutations in mucin producing tumors of the pancreas. J Surg Oncol 1994; 55:
84-91.
3. Yonekawa M, Takahashi M, Kukita K, Meguro J, Tamaki T, Kawamura K,
Yanagida N, Kurauchi N, Okano M, Imai M, Sakashita E. Influences ofextracorporeal circulation and anti-coagulants on elevation of EDA(＋)
fibronectin in plasma. Jap J Artif Organs 1995; 24: 770-774.
4. Yonekawa M, Kukita K, Kawamura K, Yanagida N, Imai M, Okano M,
Takahashi M, Meguro J, Tamaki T, Ohnishi K, Sugishita Y, Sakashita E.
Cooling system on cryofiltration. Clin Pharmaco Therapy 1995; 5: 1295-1298.
5. Takahashi M, Yanagida N, Kurauchi N, Imai M, Okano M, Tamaki T,Meguro
J, Kukita K, Yonekawa M, Kawamura K. Liver preservation under room
temperature for transplantation. J Sapporo Med Assoc 1995; 155: 255-288.
6. Takahashi M, Yonekawa M, Meguro J, Kukita K, Kawamura K, Yanagida N,
Okano M, Kurauchi N, Imai M, Ohnishi K, Sugioka Y, Sakashita E.
Development of an automatic cryofiltration system. Jap J Apheresis 1996; 15:
122-123.
7. Kato K, Kasai S, Onodera K, Sawa M, Kawabata N, Nakazawa F, Imai M,
Kino Y, Kawahara T, Jiang B, Mito M. Effectivity of human hepatocyte
growth factor for growing of transplanted hepatocytes in rat spleen. Acta
Hepato Jap 1996; 37: 187-188.
8. Kato K, Hodgson WJB, Abraham NG, Onodera K, Imai M, Kasai S, Mito M.
Expression and inducibility of cytochrome P450 IIIA family within
intrasplenically transplanted fetal hepatocytes. Cell Transplant 1996; 5: 117122.

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9. Kato K, Onodera K, Sawa M, Imai M, Kawahara T, Kasai S, Mito M. Effectof hepatocyte growth factor on the proliferation of intrasplenicallytransplanted hepatocytes in rats. Biochem Bioph Res Comm 1996; 222: 101106.
10. Kukita K, Takahashi M, Meguro J, Yonekawa M, Yanagida N, Kurauchi N,
Okano M, Imai M, Kawamura K. Analysis for against of thrombosis in double
lumen catheter apprication. Clin Dialysis 1997; 13: 121-125.
11. Kato K, Kato J, Hodgson WJB, Abraham NG, Onodera K, Imai M, Kasai S,
Mito M. Enzymatic activity and expression of cytochrome P450 Law within
intrasplenically transplanted fetal hepatocytes in spontaneously hypertensive
rats. Cell Transplant 1997; 6: 531 534.
12. Kato K, Onodera K, Imai M, Kawahara T, Kasai S, Mito M. The effect ofhuman hepatocyte growth factor by continuous injection into artery forgrowing of transplanted hepatocytes in rat spleen. Acta Hepato Jap 1997; 38:393-394.
13. Kato K, Onodera K, Sakata H, Imai M, Kato J, Hodgson WJB, Abraham NG,
Kasai S, Mito M. Fatty acid omega and (omega-1)-oxidation within
intrasplenically transplanted fetal hepatocytes. Transplantation 1998; 66: 441445.
14. Schulte am Esch II J, Sévigny J, Kaczmarek E, Siegel JB, Koziak K, Imai M,
Beaudoin AR, Robson SC. Structural elements and post-translational
modifications of CD39 influence ATP diphosphohydrolase activity.
Biochemistry 1999; 33: 2248-2258.
15. Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Schulte am Esch II J,
Imai M, Edelberg JM, Rayburn H, Lech H, Beeler DL, Csizmadia E, Wagner
DD, Rosenberg RD, Robson SC. Targeted disruption of cd39/ATP
diphosphohydrolase results in disordered hemostasis and thromboregulation.
Nature Med. 1999; 5: 1010-1017.
16. Imai M, Kaczmarek E, Koziak K, Sévigny J, Goepfert C, Guckelberger O,
Schulte am Esch II J, Robson SC. Suppression of CD39/ATPDase in humanvascular endothelial cells by antisense oligonucleotides. Biochemistry 1999; 38:
13473-13479.

217. Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia
E, Sévigny J, Rosenberg RD, Bach FH, Robson SC. Modulation of nucleoside
triphosphate diphosphohydrolase-1/cd39 in xenograft rejection. Mol Med
1999; 5: 743-752.
18. Koziak K, Kaczmarek E, Kittel A, Sevigny J, Blusztajn JK, Schulte am EschII J, Imai M, Guckelberger O, Goepfert C, Qawi I, Robson SC. Palmitoylation
targets CD39/endothelial ATP diphosphohydrolase to caveolae. J Biol Chem.
2000 Jan 21;275(3):2057-2062.
19. Imai M, Goepfert C, Kaczmarek E, Robson SC. CD39 modulates IL-1 releasefrom activated endothelial cells. Biochem Biophys Res Commun. 2000 Apr
2;270(1):272-8.
20. Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC.
CD39 modulates endothelial cell activation and apoptosis. Mol Med. 2000
Jul;6(7):591-603.
21. Imai M, Takigami K, , Guckelberger O, Kaczmarek E, Csizmadia E, Bach FH,
Robson SC. Recombinant adenoviral mediated CD39 gene transfer prolongs
cardiac xenograft survival. Transplantation. 2000 Sep 27;70(6):864-70.
22. Gangadharan SP, Imai M, Rhynhart KK, Sevigny J, Robson SC, Conte MS.
Targeting platelet aggregation: CD39 gene transfer augments nucleoside
triphosphate diphosphohydrolase activity in injured rabbit arteries. Surgery
2001 Aug;130(2):296-303.
23. Sevigny J, Sundberg C, Braum N, Guckelberger O, Csizmadia E, Qawi I,
Imai M, Zimmermann H, Robson SC. Differential catalytic properties andvascular topography of murine NTPDase 1 and 2 have implications forthromboregulation. Blood 2002 Apr;99(8): 2801-2809
24. Guckelberger O, Sun X, Sevigny J, Imai M, Kaczmarek E, Enjyoji K,
Kruskal JB, Robson SC. Beneficial effect of CD39/ecto-nucleoside
triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion
injury. Thromb Haemost 2004 Mar; 91(3): 576-86
25. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D,
Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 resultsin hepatic insulin resistance. Diabetes. 2008 Sep; 57(9): 2311-2320. Epub 2008
Jun 20.

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26. Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Csizmadia E, Candinas D, Erb L,
Robson SC. Regulated catalysis of extracellular nucleotides by vascular
CD39/ENTPD1 is required for liver regeneration. Gastroenterology. 2008 Nov;
135(5): 1751-1760. Epub 2008 Jul 31.
27. Sun X, Imai M, Nowak-Machen M, Guckelberger O, Enjyoji K, Wu Y, Khalpey
Z, Berberat P, Munasinghe J, Robson SC. Liver damage and systemic
inflammatory responses are exacerbated by the genetic deletion of CD39 intotal hepatic ischemia. Purinergic Signal. 2011 Dec;7(4):427-34. Epub 2011 Jun
9.
28. Yoshioka H, Atagi S, Katakami N, Fukuoka M,Imai M, Jap J Lung Cancer
2012; 52(5):623
29.Atagi S, Katakami N, Yoshioka H, Fukuoka M, Ogiwara A, Imai M, Ueda M,
Matsui S. Nested case control study of proteomic biomarkers for interstitiallung disease in Japanese patients with non-small-cell lung cancer treated witherlotinib: a multicenter phase 4 study (JO21661). Clinical Lung Cancer. 2013
Jul; 14(4):407-17. Epub 2013 Mar 13
30. Ohta S, Tsuru T, Terao K, Mogi S, Suzaki M, Shono E, Ishida Y, Tarumi E,
Imai M. Mechanism-based approach using a biomarker response to evaluate
tocilizumab subcutaneous injection in patients with rheumatoid arthritis withan inadequate response to synthetic DMARDs (MATSURI Study). J Clin
Pharmacol 2014 Jan;54(1):109-19. 2013 Sep;3. Epub

Proceedings of Meetings
1. Kato K, Kasai S, Onodera K, Sawa M, Imai M, Matsuda M, Kawabata T, Mito
M, Hodgson WJB. Developmental expression of cytochrome P450's within
intrasplenically transplanted fetal hepatocytes. Cell Transplant 1996; 5(1Suppl): 27S-30S .
2. Nakazawa F, Onodera K, Kato K, Sawa M, Imai M, Kasai S, Mito M. Multilocational hepatocellular transplantation for treatment of congenital ascorbic
acid deficiency rats. Cell Transplant 1996; 5(1 Suppl): 23S-25S.

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3. Kawahara T, Kato K, Sawa M, Imai M, Kasai S, Mito M. Effect of FAS andFAS ligand interaction on allogenitically transplanted hepatocytes into thespleen. Transplantation Proceedings 1997; 29: 2187-2188.
4. Kato K, Kasai S, Onodera K, Sawa M, Imai M, Kawahara T, Mito M. Effect ofhepatocyte growth factor (hHGF) on the proliferation of transplantatedhepatocytes in the spleen. Transplantation Proceedings 1997; 29: 2029-2031.
5. Robson SC, Imai M, Sévigny J, Guckelberger O, Schulte am Esch II J, Gaciong
Z, Kaczmarek E, Rosenberg RD, Enjyoji K. Pertubations in hemostasis andthrombosis in cd39-mutant mice: implications for experimental therapeutics of
CD39/NTPDase-1. In Proceeding of the Second International Workshop on
Ecto-ATPases and Related Ectonucleotidases (Vanduffel L, ed.) Shaker
Publishing BV, Maastricht, The Netherlands, pp 209-219.
6. Imai M, Takigami K, Guckelberger O, Lin Y, Sevigny J, Kaczmarek E,
Goepfert C, Enjyoji K, Bach FH, Rosenberg RD, Robson SC. CD39/vascular
ATP diphosphohydrolase modulates xenograft survival. Transplant Proc. 2000
Aug;32(5):969.
7. Gopfert C, Buhler L, Wise R, Basker M, Gojo S, Imai M, Alwayn I, Sachs DH,
Sackstein R, Cooper DK, Robson SC. Von willebrand factor concentration,
multimeric patterns, and cleaving protease activity in baboons undergoing
xenogeneic peripheral blood stem cell transplantation. Transplant Proc.
2000 Aug;32(5):990.
8. Imai M. HCV treatment: present practice and the significance. Takasaki Med
J. 2019; 69: 39-43

Reviews and Editorials
1. Robson SC, Sevigny J, Imai M, Enjyoji K. Thromboregulatory potential ofendothelial CD39/nucleoside triphosphate diphosphohydrolase: modulation ofpurinergic signalling in platelets. Emerging Therapeutic Targets; 2000: 4: 155171.

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2. Robson SC, Enjyoji K, Goepfert C, Imai M, Kaczmarek E, Lin Y, Sevigny J,
Warny M. Modulation of extracellular nucleotide-mediated signaling by
CD39/nucleoside triphosphate diphosphohydrolase-1.
Drug Development
Research; 2001: 53: 193-207.
3. Imai M. The 119th congress of the German Surgical Society and Charite, Campus
Virchow-Klinikum. J Jap Surg Society; 2002: 103: 629-631

Clinical Communications
1. Tsuji Y, Imai M, Katsuki Y, Yasuda T, Nishimura A. A case of liver metastasis
from bile duct cancer effectively treated with hepatic artery infusion
chemotherapy. Jap J Cancer Chemo 1994; 21: 2194-2197.
2. Takahashi M, Yanagida N, Kurauchi N, Okano M, Imai M, Meguro J, Kukita
K, Yonekawa M, Kawamura K. Diabetic renal failure and lung congestion.
Intensive Therapy 1995 ; 7 Suppl : 65-66.
3. Yanagida N, Kurauchi N, Imai M, Okano M, Takahashi M, Tamaki T, Meguro
J, Kukita K, Yonekawa M, Kawamura K. A case report of living-related
kidney transplantation with difficult discrimination between acute rejection
and cyclosporine- induced nephrotoxicity. J Sapporo Med Assoc 1995; 155:
128-132.
4. Imai M, Kukita K, Yanagida N, Kurauchi N, Okano M, Takahashi M, Tamaki
T, Meguro J, Yonekawa M, Kawamura K. Management for acute hemorrhage
on patient with chronic renal failure. J Sapporo Hosp Assoc 1995; 15: 98-100.
5. Kato K, Kasai S, Matsuda M, Onodera K, Kato J, Imai M, Mito M, Saito T. A
new technique for laparoscopic cholecystectomy - Retrograde laparoscopiccholecystectomy - An analysis of 81 cases. Endoscopy 1996; 28: 356-359.
6. Kato K, Matsuda M, Ingu A, Imai M, Kasai S, Mito M, Kobayashi T. Coloncancer with a high serum α-fetoprotein level. Am J Gastroenterol 1996; 91:1045-1046.

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7. Imai M, Kato K, Kino S, Kamiya K, Matsuda M, Kasai S, Mito M. Experience
with laparoscopic cholecystectomy for management of chronic cholecystitis
with severe adhesion : Report of a case. J Jap Biliary Assoc 1996; 10: 169-174.
8. Kato K, Matsuda M, Aoki H, Imai M, Onodera K, Kasai S, Mito M, Kobayashi
T. A successful treatment for mucosal prolapse syndrome by the steroid enema
therapy in a postoperative patient of mesenteric panniculitis. Japanese J
Gastro-enterology 1996; 93: 565-568.
9. Kato K, Matsuda M, Onodera K, Kino S, Kamiya K, Imai M, Waku K, Kasai
S, Mito M. Successful treatment of a rectal leasion by transanal endoscopic
microsurgery. Clin J Surg 1996; 58: 1133-1137.
10. Kato K, Matsuda M, Imai M, Kasai S, Saito T, Mito M. Successful Treatmentof a rectal anastomotic stenosis by transanal endoscopic microsurgery (TEM)
using the contact ND:YAG laser. Surg Endosco 1997; 11: 485-487.
11. Kato K, Matsuda M, Imai M, Kasai S, Mito M. A new trocar insertion site forlaparoscopic surgery : the Xiphoidal Approach. Surg Technol Internatio 1998;
6: 127-131.
12. Kato K, Matsuda M, Onodera K, Sakata H, Imai M, Kasai S, Kobayashi T.
Successful Treatment of a rectal lesion by transanal endoscopic microsurgery
with the ultrasonically activated scalpel-A new technical report. Mimimally
Invasive Therapy & Allied Technologies 1998; 7: 307-310.
13. Kawabata N, Kato K, Imai M, Kasai S, Mito M. Experience of using Endopath
disposable 33mm Trocar (LTK33) in laparoscopic cholecystectomy. Clin J Surg
1998; 60: 314- , 1998.
14. Kato K, Onodea K, Sakata H, Matsuda M, Imai M, Ksai S. An automatic
stapling device for laparoscopic cholecystectomy in sevire cholecystitis.
Endoscopic Surgery 1998, 473-476.
15. Imai M, Kondo Y, Okada K, Osawa S, Ishizu H, Masuko H, Nishida Y,
Uebayashi T, Takahashi M, Watanabe N, Aoki G, Osada T, Ishiyama G. An
analysis of 34 cases of esophagus cancer patients with esophagectomy in resent
5 years. Hokkaido Noson Igakkaishi 2001; 33: 106-107.
16. Ishizu H, Kondo Y, Okada K, Osawa S, Masuko H, Imai M. Three cases ofmalignant cystic tumor of the liver. J Jap Surg Asso 2002; 63: 2234-2239.

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17. Imai M, Kondo Y, Osawa S, Nishida Y, Okada K, Ishizu H, Masuko H, Hata T,
Uemura K, Kina M, Honda S, Ishiyama G, Takahashi T, Hino A.
Clinicopathological Characteristics of Superficial Spreading Type Early
Gastric Cancer. J Surg Oncol 2003; 83: 94-98.
18. Imai M, Kondo Y, Masuko H, Okada K, Osawa S, Ishizu H, Nishida Y, Hata T,
Uemura K, Kina M. Honda S, Ishiyama G, Takahashi T, Hino A. Distant
Peritoneal Metastasis to Mesh-Plug Prosthesis in a Gastrointestial Cancer
Patient: Report of a Case. Surg Today 2003; 33: 864-866.
19. Inagaki M, Obara M, Kino S, Hagiwara M, Yamazaki H, Ishizaki A, Imai M,
Tokusashi Y, Miyokawa N, Kawashima T, Hasebe C, Kasai S. Small cell
carcinoma of the gallgladder: report of a case. Hokkaido J. Surg 2003; 48: 158161.
20. Aoki K, Imai M, Kanke D, Kumano H, Tanaka M, Komori T, Sunagawa M.
Simultaneous Existence of Gastrointestinal Stromal Tumor andAdenocarcinoma in the Stomach with Gastrointestinal Hemorrhage – Reportof a Case. Nihon Gekakei Rengou Gakkaishi 2015; 40: 699-704
21. Hirosawa T, Morimoto N, Miura K, Tahara T, Murohisa T, Okamura Y, SatoT, Numao N, Imai M, Tano S, Murayama K, Kurita H, Ozawa I, Fukaya Y,
Yoshizumi H, Watanabe S, Tsukui M, Takaoka Y, Nomoto H, Isoda N,
Yamamoto H. No Regional Disparities in Sofosbuvir Plus Ribavirin Therapy
for HCV Genotype 2 Infection in Tochigi Prefecture and its Vicinity. Internal
Medicine 2018: 1194-18
22. Aoki K, Imai M, Mori K, Ishii T, Kumano H, Kusakabe T. A case of goblet cell
carcinoid coexist with low grade appendiceal mucinous neoplasm of thaddendix. Nihon Gekakei Rengou Gakkaishi 2022
23. Watanabe N, Imai M, Aoki K, Shinjyo T, Ishii T, Kumano H, Sunagawa M.
Trans epiploic hernia: a report of two cases and literature review of 247 caseswith trend of five years in Japan. J Abdo Emerg Med (submitted)

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ThesisImai M. High incidence of K-ras gene mutations in extrahepatic biliary tract
tumors detected by PCR-denaturing gradient gel electrophoresis.
PhD Thesis: Asahikawa Medical College, 1992

Abstracts (English presentation)
1. Ogawa K, Imai M, Hoshi T, Ohta T. Identification of K-ras and p-53 genemutations by GC-clamped DGGE in human and animal cancers. Proc. 83Th
Annual Meeting of AACR, San Diego, USA 1992; 33: 111.
2. Hoshi T, Imai M, Ogawa K, Mito M. Frequent K-ras mutations and absence of
p53 mutations in mucin-producing tumors of the pancreas. ABSTRACT
BOOK XXVIII Congress of ESSR, Turku, Finland 1993; 29: 129.
3. Imai M, Hoshi T, Ogawa K, Mito M. High incidence of K-ras gene mutations
in extrahepatic biliary tract tumors detected by PCR-denaturing gradient gelelectrophoresis. ABSTRACT BOOK XXVIII Congress of ESSR, Turku,
Finland 1993; 29: 130.
4. Kukita K, Yanagida N, Kurauchi N, Okano M, Imai M, Takahashi M, Meguro
J, Tamaki T, Yonekawa M, Kawamura K, Kasai M, Kohgo Y. The transferrin
receptor and hemopoiesis of maintenance hemodialysis patients. Proc. XthWorld Congress of International Society for Artificial Organs; 1995 Nov 14-18;
Taipei, Taiwan
5. Kato K, Matsuda M, Imai M, Kasai S, Saito T, Mito M. Transanal endoscopic
microsurgery (TEM) using contact laser for rectal anastomotic stenosis. Proc.
5Th World Congress of Surgical Endoscopy, Philadelphia, USA 1995; 5: 212.
6. Inagaki M, Maguchi M, Suzuki S, Imai M, Kamiya K, Kino S, Kasai S, Mito
M. A study of 36 operative cases with mucin-producing tumor of the pancreas.
Proc. 87Th Annual Meeting of AACR, Washington DC, USA1996; 37: 210.

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7. Kato K, Matsuda M, Kino S, Maguchi S, Inagaki M, Imai M, Kasai S, Mito M,
Saito T. A new trocar insertion site for laparoscopic surgery : Xiphoidal
Approach. Minimally Invasive Therapy & Allied Technologies 1996; 5 Suppl
1: 104.
8. Imai M, Kato K, Matsuda M, Kino S, Maguchi S, Inagaki M, Kasai S, Mito M.
Laparoscopic assistant low anterior resection using ROTICULATOR™ with amini-laparotomy. Minimally Invasive Therapy & Allied Technologies 1996; 5
Suppl 1: 113.
9. Kato K, Kasai S, Onodera K, Sawa M, Imai M, Kawahara T, Mito M. Effect ofthe proliferation of intrasplenically transplanted hepatocytes in rats. Cell
Transplantation 1996 ; 5(2 Suppl) : 21S.
10. Sawa M, Jiang B, Lin H, Nakazawa F, Kawahara T, Kino Y, Imai M, Mamiya
N, Kato K, Kasai S, Mito M. Proliferation of intrasplenically transplanted
hepatocytes in rats with chronic hepatic failure. Cell Transplantation 1996; 5(2Suppl): 22S.
11. Imai M, Kawabata N, Kato K, Kawahara T, Nakazawa F, Sawa M, Kasai S,
Mito M. Successful xenograft in streptozotocin induced diabetic rat using
dispersed hamster islet tissue within microporous polypropylene bag. Cell
Transplantation 1996; 5(2 Suppl): 51S.
12. Kawahara T, Kato K, Sawa M, Imai M, Kasai S, Azuma M, Yagita H,
Okumura K, Futagawa S, Mito M. Effect of FAS and FAS ligand interaction
on allogenitically transplanted hepatocytes into the spleen. Cell
Transplantation 1996 ; 5(2 Suppl) : 63S.
13. Schulte am Esch II J, Kaczmarek E, Siegel JB, Koziak K, Sévigny J, Imai M,
Beaudoin AR, Bach FH. Robson SC. Mutagenesis of vascular ATP
diphosphohydrolase. 39th Annual Meeting American Society of Hematology;
1997 Decem 5-9; San Diego CA
14. Schulte am Esch II J, Kaczmarek E, Siegel JB, Koziak K, Sévigny J, Imai M,
Beaudoin AR, Bach FH. Robson SC. Characterization and mutagenesis of
CD39/vascular ATP diphosphohydrolase. Circulation 1997; 96(8): 6.
15. Imai M, Robson SC. Inhibition of CD39/ATPDase in human endothelial cellsby antisense oligonucleotides. Blood 1998; 90 (Supp 2): 77b

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16. Imai M, Kaczmarek E, Koziak K, Sévigny J, Robson SC. Inhibition of
CD39/ATPDase in human endothelial cells by antisense oligonucleotides.
Experimental Biology, FASEB, Washington DC, USA. FASEB J 1999; 13(4):A200
17. Sévigny J, Enjyoji K, Lin Y, Schulte am Esch II J, Imai M, Rosenberg RD,
Robson SC. Disordered hemostasis and thromboregulation in cd39-deficientmice. Experimental Biology, FASEB, Washington DC, USA. FASEB J 1999;
13(5): A839
18. Robson SC, Enjyoji K, Sévigny J, Lin Y, Imai M, Schulte am Esch II J,
Gaciong Z, Gaciong Z, Kaczmarek E. Therapeutic potential of CD39/ATPDasefor vascular inflammatory conditions. Second International Workshop on
Ecto-ATPases and Related Ectonucleotidases Diepenbeek, Belgium 1999;
Abstract book p.28
19. Imai M, Kaczmarek E, Sévigny J, Robson SC. Inhibition of ATP
diphosphohydrolase/CD39 in human endothelial cells. Second International
Workshop on Ecto-ATPases and Related Ectonucleotidases Diepenbeek,
Belgium 1999; Abstract book p.58
20. Imai M, Takigami K, Kaczmarek E, Koziak K, Sévigny J, Goepfert C,
Guckelgerger O, Robson SC. Adenovirus-mediated CD39 gene transfer into
endothelial cells prolongs cardiac xenograft survival. The 6th Basic Sciences
Symposium of the Transplantation Society, Monterey peninsula, CA, USA
1999.
21. Imai M, Takigami K, Guckelgerger O, Lin Y, Sévigny J, Enjyoji K, Rosenberg
RD, Robson SC. CD39/Vascular ATP diphosphohydrolase modulates xenograft
survival. The 5th Congress of the Int. Xenotransplantation Association, Nagoya,Japan 1999.
22. Imai M, Takigami K, Kaczmarek E, Koziak K, Sévigny J, Goepfert C,
Guckelgerger O, Robson SC. CD39 gene transfer prolongs discordant
xenograft survival. The 5th Congress of the Int. Xenotransplantation
Association, Nagoya, Japan 1999.
23. Goepfert C, Buhler L, Wise R, Basker M, Gojo S, Imai M, Sachs DH, Sackstein
R, Robson SC, Cooper DKC. Xenogeneic peripheral stem cell transplantation
in baboons is complicated by a thrombotic disorder. The 5th Congress of theInt. Xenotransplantation Association, Nagoya, Japan 1999.

11

24. Imai M, Guckelgerger O, Robson SC. Over-expression of CD39/ATP
diphosphohydrolase exacerbates lipopolysaccharide/galactosamine induced
hepatic failure. American Association for the Study of Liver Disease (AASLD),
Dallas, TX, USA 1999.
25. Goepfert C, Buhler L, Alwan I, Basker M, Imai M, Tsai HM, Sachs DH,
Cooper DKC, Sackstein R, Robson SC. Thrombotic thrombocytopenic purpura
following peripheral blood progenitor cell xenotransplantation occurs
independently of rrant vWF multimer proteolysis. Blood 1999; 94(10) (Supp 1):
13a
26. Guckelberger O, Sévigny J, Kruskal J, Imai M, Kaczmarek E, Goepfert C,
Neuhaus P, Robson SC. (1999) Ecto-nucleotidases reduce ischemia reperfusion
injury in the small intestine. German Transplantation Society: 1999 Nov 25-27;
Dresden, Germany. Transplantationsmedizin Supplement 88-89.
27. Guckelberger O, Imai M, Sévigny J, Kruskal JB, Kaczmarek E, Robson SC.
Apyrase administration attenuates small intestine ischemia/reperfusion injury
in mice. J Jpn Surg Soc 2000; 101(Supp): 36
28. Guckelberger O, Imai M, Dodson M, Sévigny J, Kahn CR, Robson SC.
Impaired Hepatic Regeneration in Liver-specific insulin receptor knockout
mice. Transplant 2000 Joint American Transplant Meeting of the American
Society of Transplant Surgeons and American Society of Transplantation: 2000
May 16-21; Chicago, USA
29. Guckelberger O, Imai M, Sévigny J, Kruskal JB, Kaczmarek E, Enjyoji K,
Robson SC. CD39 is a crucial modulator of platelet and endothelial cell
activation in ischemic/reperfusion injury. First Conference on Arteriosclerosis,
Thrombosis, and Vascular Biology, 2000 May 20-22, Denver, CO, USA
30. Robson SC, Guckelberger O, Sévigny J, Imai M, Enjyoji K, Rosenberg RD.
CD39 is a Novel Thromboregulatory Factor with Therapeutic Potential in
Vascular Disease. First Conference on Arteriosclerosis, Thrombosis, and
Vascular Biology, 2000 May 20-22, Denver, CO, USA
31. Goepfert C, Imai M, Brouard S, Csizmadia E, Kaczmarek E, Robson SC.
Vascular ATPDase CD39 Modulates EC Activation and Apoptosis. First
Conference on Arteriosclerosis, Thrombosis, and Vascular Biology, 2000 May
20-22, Denver, CO, USA1232. Imai M, Goepfert C, Kaczmarek E, Guckelberger O, Sévigny J, Robson SC.
CD39 Modulate IL-1a Release and Synthesis from Activated Endothelial Cells.
First Conference on Arteriosclerosis, Thrombosis, and Vascular Biology, 2000
May 20-22, Denver, CO, USA
33. Sévigny J, Guckelberger O, Csizmadia E, Imai M, Goepfert C, Enjyoji K,
Robson SC. Different Nucleoside Triphosphate Diphosphohydrolases are
Associated with Endothelial Cells. First Conference on Arteriosclerosis,
Thrombosis, and Vascular Biology, 2000 May 20-22, Denver, CO, USA
34. Guckelberger O, Imai M, Sévigny J, Kruskal JB, Kaczmarek E, Neuhous P,
Robson SC. CD39 plays a crucial role in ischemia/reperfusion injury. XVIIIInternational Congress of the Transplantation Society: 2000 Aug 27-Sep 1;
Rome, Italy
35. Imai M, Guckelberger O, Sevigny J, Lin Y, Xiaofeng S, Enjyoji K, Robson SC.
CD39, the vascular nucleoside triphosphate diphosphohydrolase-1, is a crucial
modulator of murine hepatic ischemia/reperfusion injury. The 7th Congress ofInternational Liver Transplantation Society: 2001 July 11-13; Berlin, Germany
36. Imai M, Kondo Y, Osawa S, Nishida Y, Okada K, Ishizu H, Masuko H, Hata T,
Uemura K, Kina M. honda S, Ishiyama G, Takahashi T, Hino A. Superficial
spreading type of early gastric cancer. International Gastrointestinal Cancer
Conference: 2001 Sep 27-29; Innsbruck, Austria
37. Robson SC, Xiaofeng S, Guckelberger O, Enjyoji K, Imai M. CD39, thevascular ecto-nucleoside triphosphate diphosphohydrolase-1, is a crucial
modulator of hepatic ischemia/reperfusion injury. American Association for the
Study of Liver Disease (AASLD): 2001 Nov 10-13, Dallas, TX, USA 2001.
38. Imai M, Kondo Y, Osawa S, Nishida Y, Okada K, Ishizu H, Masuko H, Hata T,
Uemura K, Kina M. honda S, Ishiyama G, Takahashi T, Hino A. Superficial
spreading type of early gastric cancer. World Congress of Gastroenterology:
2002 February 24-March 1; Bangkok, Thailand
39. Wu Y, Sun X, Imai M, Sultan B, Csizmadia E, Enjyoji K, Jackson SW, Usheva
A, Robson SC. Modulation of Ras/Erk signaling by CD39/ENTPD1 during
liver regeneration. American Association for the Study of Liver Disease(AASLD): 2005 Nov 11-15; San Francisco, CA, USA.

1340. Wu Y, Imai M, Sun X, Csizmadia E, Enjyoji K, Choi CH, Robson SC, Usheva
A. Transcription factor YY1 and the retinoblastoma protein are downstream
targets of CD39/ENTPD1 signaling pathways during liver regeneration.
American Association for the Study of Liver Disease (AASLD): 2005 Nov 1115; San Francisco, CA, USA.
41. Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Zimmermann H, Candinas D,
Robson SC. The vascular ectonucleotidase CD39 is permissive for sinusoidal
endothelial cell proloferation during liver regeneration. American Association
for the Study of Liver Disease (AASLD): 2006 Oct 27-31; Boston, MA, USA.
42. Terao K, Ohta S, Tsuru T, Mogi S, Suzaki M, Nakashima H, Shono E, Imai M.
Prediction of optimal clinical dose using pharmacokinetic/biomarker responceof Tocilizumab subcutaneous injection to patients with rheumatoid arthritis.
The 19th International Rheumatology Symposium: 2010 April 22-25; Kobe,
Japan.
43. Ohta S, Tsuru T, Terao K, Mogi S, Suzaki M, Nakashima H, Shono E, Imai M.
Subcutaneous repeated injection of Tocilizumab in patients with RA: Doseassessment study by efficacy and pharmacokinetics (Phase I/II study). The 19thInternational Rheumatology Symposium: 2010 April 22-25; Kobe, Japan.
44. Keeffe EB, Imai M. Randomized, Double-Blind, Placebo-Controlled study ofNitazoxanide plus Peginterferon/Ribavirin in genotype 1 naive patients: StealthC-3, The 46th Annual Meeting of Japan Society of Hepatology: 2010 May 27-28;
Yamagata, Japan.
45. Ohta S, Tsuru T, Suzaki M, Mogi S, Ikuno S, Nakajima K, Imai M, Tusumi E,
Terao K. Dose prediction by pharmacokinetic and biomarker response of
subcutaneous tocilizumab treatment. -A Phase I/II study evaluating the safety,
pharmacokinetics and clinical response in patients with rheumatoid Arthritis.
the 2010 ACR/ARHP Annual Scientific Meeting: 2010 November 6 -11, Atlanta,
GA, USA.
46. Katakami N, Atagi S, Yoshioka H, Fukuoka M, Ogiwara A, Imai M, Ueda M,
Matsui S. Nested case control study of proteomic biomarkers for interstitiallung disease in Japanese patients with non-small cell lung cancer treated witherlotinib. 5th Asia Pacific Lung Cancer Conference: 2012 November 25-28,
Fukuoka, Japan.

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47. Imai M, Nakamichi T, Koyanagi R, Hirashima H, Aoki K, Kumano H, Tanaka
M, Komori T, Sawa M, Sunagawa M. The first safety report of high aged
patients over 76 years old administered Dacratasvir and Asnaprevir in single
center experience in Japan. 24th Asian Pacific Association for Study of theLiver: 2015 March 12-15, Istanbul, Turkey.
48. Shimizu Y, Taketomi M, Matsuyama T, Shin R, Otani Y, Okazaki T, Fukao Y,
Kano T, Io H, Imai M. Introduction and Effectiveness of Rehabilitation
Therapy for a Peritoneal Dialysis Patient. 29th Annual Meeting of the JapaneseSociety for Dialysis Therapy; 2023 September 30-October 1, Tokyo, Japan.

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