Animal Models (commercially available) in Japan
Model Disease

Species

Breeder
Refarence

Commercial nameCharacteristics

Japan SLC, Inc
Sales Department
3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

AKITA/Slc
Type 1 diabetes

slc03@jslc.co.jp
CLEA Japan,Inc.
Tokyo Animal & Diet Dept.
NOD/ShiJcl

1-2-7 Higashiyama Meguro-ku Tokyo
TEL:+81-3-5704-7050
FAX:+81-3-3792-2032

CLEA Japan,Inc.
Tokyo Animal & Diet Dept.

KK/TaJcl
KK-A y /TaJcl
db

BKS.Cg-m+/+Lepr /Jcl
obB6.Cg-Lep /JJAX® Mice
Domestic production
JAX® Mice

1-2-7 Higashiyama Meguro-ku Tokyo
TEL:+81-3-5704-7050
FAX:+81-3-3792-2032

CHARLES RIVER LABORATORIES JAPAN, INC.
Customer support center
3-17-6 Shinyokohama Kouhoku-ku Yokohama Kanagawa
TEL:+81-45-474-9340
FAX:+81-45-474-9341

abnormal pancreatic B cells, mutation of the insulin 2 gene, ER stress
http://www.jslc.co.jp/disease/c03_f.htm

autoimmune disease, insulitis, cytokine, major histocompatibility complex
http://www.clea-japan.com/animalpege/a_1/b_05.html
polygenic model, obese, insulin resistance, hyperinsulinemia
http://www.clea-japan.com/animalpege/a_1/b_01.html
yinsulin resistance, hyperinsulinemia, obese, A gene
http://www.clea-japan.com/animalpege/a_1/b_02.html
insulin resistance, hyperinsulinemia, obese, abnormality of leptin receptor
http://www.clea-japan.com/animalpege/a_1/b_03.html
ob/ob mouseabnormality of leptin
http://202.32.114.138/product/domestic/detail/43

web_order@crl.com
Japan SLC, Inc
Sales Department
C57BL/6J Ham Slc-Lep ob3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese, abnormality of leptin
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
BKS.Cg-Dock7 m +/+Lepr db /JJAX® Mice
Domestic production

CHARLES RIVER LABORATORIES JAPAN, INC.
Customer support center
3-17-6 Shinyokohama Kouhoku-ku Yokohama Kanagawa
TEL:+81-45-474-9340
FAX:+81-45-474-9341

web_order@crl.com
Mouse

BTBR.Cg-Lepob/WiscJ #004824
Import from The JacksonLaboratory U.S.A JAX® Micehuman non-insulin-dependent type 2 diabetes mellitus (NIDDM). Male TALLYHO
mice can develop hyperglycemia, hyperinsulinemia, hyperlipidemia, moderate
obesityphenotypelessthanof100%
penetrant
and enlargementof is
theislets
Langerhans,
however, the however, the phenotype
isless than 100% penetrant.
https://www.jax.org/strain/005314

TALLYHO/JngJ #005314
Import from The JacksonLaboratory U.S.A
JAX® Mice

Diabetes

obese, diabetic, dyslipidemia,insulin resistance, abnormality of leptin receptor
receptor, diabetic complication
https://www.jax.org/strain/004824
human obesity-induced Type 2 diabetes and metabolic Syndrome.
https://www.jax.org/strain/004456

NONcNZO10/LtJ #004456
Import from The JacksonLaboratory U.S.A
JAX® Mice

Type 2diabetes

db/db mouseobese, diabetic, abnormality of leptin receptor
http://www.crj.co.jp/product/domestic/detail/34

Institute for Animal Reproduction
C57BLKs/J Iardb+Lepr /+Lepr

db●Refarence
Japan SLC, Inc Sales Department
3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese, abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Hoshino Laboratory Animals
NSY●Refarence
Japan SLC, Inc Sales Department
3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

impaired glucose tolerance
diabetic nephropathy http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Institute for Animal Reproduction
TSOD●Refarence
Japan SLC, Inc Sales Department
3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese,diabetic,
diabetic complication
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
Type 1diabetesKDP

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

insulitis
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
GK/SlcSDT/Jcl
Rat
SDT.Cｇ-Lepr fa/JttJcl

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

slc03@jslc.co.jp
CLEA Japan,Inc.
Tokyo Animal & Diet Dept.
1-2-7 Higashiyama Meguro-ku Tokyo
TEL:+81-3-5704-7050
FAX:+81-3-3792-2032(SDT fatty)

Impaired Glucose Tolerance,polygenic model, non obese
http://www.jslc.co.jp/disease/c03_f.htm

nonobese, impaired insulin secretion, glucose intolerance, diabetic complication
http://www.clea-japan.com/animalpege/a_1/b_09.html
obesity, insulin resistance, diabetic complication, osteopenia, hypertension
http://www.clea-japan.com/animalpege/a_1/b_10.html

CHARLES RIVER LABORATORIES JAPAN, INC.
fa
ZDF-Lepr /CrlCrlj
Domestic production

Customer support center3-17-6 Shinyokohama Kouhoku-ku Yokohama Kanagawa
TEL:+81-45-474-9340
FAX:+81-45-474-9341

obese, diabetic, dyslipidemia,insulin resistance, abnormality of leptin receptor
http://www.crj.co.jp/product/domestic05.html

web_order@crl.com
Japan SLC, Inc
Sales Department
WBN/Kob Slc

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

pancreatitis, diabetic complication
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
C57BL/6J Ham Slc-A y3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp

Mouse

C57BL/6J DIO(Diet Induced Obesity)
Domestic production
JAX® Mice

CHARLES RIVER LABORATORIES JAPAN, INC.
Customer support center

Diet-Induced Obesity,hyperglycemia, insulin resistance
http://202.32.114.138/product/domestic/detail/26

3-17-6 Shinyokohama Kouhoku-ku Yokohama Kanagawa
TEL:+81-45-474-9340
FAX:+81-45-474-9341
fa

Crlj:ZUC-LeprDomestic production

web_order@crl.com

obese, dyslipidemia,insulin resistance,abnormality of leptin receptor
http://202.32.114.138/product/domestic/detail/12

Japan SLC, Inc
Sales Department
Slc:Zucker fa/fa

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese, dyslipidemia,insulin resistance,abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Hoshino Laboratory Animals

Obesity

Hos:Zucker-fa/fa●Refarence
Japan SLC, Inc
Sales Department
3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department

Ratfa

DahlS.Z-Lepr /Slc3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese, dyslipidemia,insulin resistance, abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

obese, hypertensive, heart failure, metabolic syndrome, abnormality of leptinreceptor
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
SHRSP/IzmDmcr-fa

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

stroke, hypertensive, obese, metabolic syndrome, abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
WBN/KobSlc-Lepr fa

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

obese, diabetic,pancreatitis,abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

slc03@jslc.co.jp
Japan SLC, Inc
Sales Department
SHR/NDmcr-cp

3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
TEL:+81-53-486-3178
FAX:+81-53-486-3156

slc03@jslc.co.jp
C57BL/6.KOR/Stm Slc-Apoe shl Japan SLC, Inc
Sales Department
shl 3371-8, Kotou-cho Nishi-ku Hamamatsu Shizuoka
BALB/c.KOR/Stm Slc-Apoe
Dyslipidemia

TEL:+81-53-486-3178

Mouse

C3H/He.KOR/Stm Slc-Apoe shl FAX:+81-53-486-3156
slc03@jslc.co.jp
DBA/2.KOR/Stm Slc-Apoe shlNon-alcoholicsteatohepatitis

Mouse

C57BL/6J-NASH
Domestic production
JAX® MiceCHARLES RIVER LABORATORIES JAPAN, INC.
Customer support center
3-17-6 Shinyokohama Kouhoku-ku Yokohama Kanagawa
TEL:+81-45-474-9340
FAX:+81-45-474-9341

obese, hypertensive, diabetic,abnormality of leptin receptor
http://www.jslc.co.jp/disease/c03_f.htm

spontaneously hyperlipidemic (SHL) mice、Hyperlipidemia、arteriosclerosis,
congenic strain
http://www.informatics.jax.org/javawi2/servlet/WIFetch?page=alleleDetail&key=373
34
http://www.jslc.co.jp/inform/shl_basic_data.pdf

Feeding A06071302 (60Kcal% fat) more than six months, will develop NASH-like
disease (SPF)
A06071309 fed models also available (45Kcal% fat diet)
http://www.crj.co.jp/product/domestic/detail/40

web_order@crl.com
Note: Japan SLC, Inc. (Tel +81-53-486-3178) accepts animals of Institute for Animal Reproduction and Hoshino Laboratory Animals.
（Revision on January 21, 2019）