New Genetic and Metabolic Insights into Animal Models of Diabetes, Bar Harbor, Maine, June 17-21.
MEETING AT A GLANCE
WednesdayJune 18thEdLeiterGreetings Ballroom

8:30 AM Welcoming Remarks

JohnMordes

PlenaryBallroom

8:35 AM Autoimmune Diabetes in the Rat

HelleMarkholst

Track 1Walsh House

Tsukasa

Hirashima

Track 2

Ballroom

NorihideYokoi

Track 1Walsh House

9:20 AM The Iam4L1 Gene: The Lymphopenia Gene of the BB Rat
The Otsuka Long-Evans Tokushima Fatty (OLETF) Rat, an animal model of Type
9:20 AM II diabetes: Establishment, Characteristics and Pathogenesis
The KDP rat: identification of the Cblb mutation and establishment of a segregating
9:45 AM inbred strain

BernardPorthaTrack 2

Ballroom

SigurdLenzen

Track 1Walsh House

CharlesBurant

Track 2Ballroom

9:45 AM New Developments Using the GK rat as a model of Type 2 diabetes
Basic characteristics of the LEW.1AR1/Ztm-iddm rat - A new model of
10:10 AM spontaneous IDDM
The microvasculature in the hyperplasia and atrophy of pancreatic islets in the ZDF
10:10 AM rat

BreakMichael

Clare-Salzler

Track 1Walsh House

10:30 AM refreshments are available in each track location
The biology of macrophages and dendritic cells biology in NOD and human type 1
10:50 AM diabetes

BarbaraHansen

Track 2

Ballroom

10:50 AM Diabetes and Metabolic Syndrome in Monkeys: Use as research models.

ChantalMathieu

Track 1Walsh House

11:15 AM The NOD mouse: from bench to clinic

Anthony

Comuzzie

Track 2

Ballroom

FraserScott

Track 1Walsh House

11:15 AM The baboon as a model for the genetic study of obesity and diabetes
Plasticity of islet homeostasis in BB rats: tubular complex formation and extra-islet
11:40 AM insulin+, neurogenin-3+ clusters

DomenicoAccili

Track 2Ballroom

11:40 AM New Models of Type 2 Diabetes

LunchHiroshi

IkegamiPlenaryBallroom

12:00 PM Edenfield Dining Room, one floor above the ballroom
Genetics of Type 1 and Type 2 diabetes in inbred strains derived from the same
1:15 PM outbred colony

ChristopheBenoist

Track 1Walsh House

2:00 PM New technologies for the study of NOD autoimmune etiopathogenesis

SarahZangen

Track 2Ballroom

DavidSerreze

Track 1Walsh House

2:00 PM Cohen Diabetic Rat - a genetic model of inducible Type 2 diabetes mellitus
Use of genetically engineered NOD mice to dissect diabetogenic immune
2:25 PM dysfuntions

TetsuroIzumi

Track 2Ballroom

2:25 PM Genetic Analysis of obese diabetes in the TSOD mouse

Alexander

Chervonsky

Track 1Walsh House

ClaytonMathews

Track 2

Ballroom

2:50 PM Animal models to study autoimmune destruction of the ß cells
ALS/Lt: A New Mouse Model of Diabetes Susceptibility Associated with Low Free
2:50 PM Radical Scavenging PotentialBreak

3:10 PM Track one finished for the day, Track 2 continues

JuergenNaggert

Track 2

Ballroom

3:30 PM TallyHo Mouse

SusanneCleeTrack 2Ballroom

3:55 PM The BTBR-ob mouse model of type 2 diabetesHans

Joost

Track 2Ballroom

4:20 PM Gene-Diet interaction in the development of diabesity in New-Zealand obese miceBreak

4:30 PM session end

ThursdayJune 19thRichard

Flavell

Plenary

Ballroom

MicheleMarronTrack 1Walsh House

8:35 AM Genetic Manipulation of Immune and Autoimmune Response
Modeling human MHC class I diabetes functions through transgenic expression in
9:20 AM NOD mice

Marc

ReitmanTrack 2

Ballroom

9:20 AM The physiology of lipoatrophy deduced from the A-ZIP/F-1 mouseMyraLipesTrack 1

Walsh House

9:45 AM HLA-DQ8 transgenic mice as a model for human autoimmune diseases

YakiBarak

Track 2Ballroom

MarkAtkinson

Track 1Walsh House

9:45 AM PPARg, lipodystrophy, and metabolic disease
Gene Therapy Applications for Diabetes: Use for Animal Models for Studies of
10:10 AM Prevention, Complilcations, Transplantation, and Metabolic Monitoring

John-OlovJansson

Track 2Ballroom

10:10 AM Cytokine Knock Out and Obesity

BreakIvanGerling

Track 1Walsh House

J.E.

Friedman

Track 2

BallroomSuzanneBerteraTrack 1Walsh House

10:30 AM refreshments are available in each track location
Characterization of Early Developments in the Islet Transcriptome of Young NOD
10:50 AM Mice.
integral role for CCAAT/ENHANCER binding protein (C/EBP b) in regulation of
10:50 AM energy intake and hepatic function
INS-C-TIMER transgenic mice produce insulin with a fluorescent marker that
11:15 AM changes color over time

BangyanStilesTrack 2

Ballroom

11:05 AM Tissue specific deletions of PTEN result in increased insulin sensitivity in mice

DomDeluca

Track 1Walsh House

R.S.

Garofalo

Track 2

Ballroom

TerrieCock

Track 2LunchBallroom

11:40 AM Development of an in vitro thymic organ culture system for human type 1 diabetes
Mice lacking AKT2/PKBb are growth deficient, lipoatrophic and develop severe
11:20 AM diabetes
The peroxisome proliferator-activated receptor g2 isoform control adipogenesis in
11:45 AM vivo
12:00 PM Edenfield Dining Room, one floor above the ballroom

Leonard

ShultzPlenary

Ballroom

1:15 PM Humanized Mouse Models for Transplant ResearchWilliam

Ridgeway

Track 1Walsh House

CarinaAmmalaTrack 2

Ballroom

Dale

GrenierTrack 1Walsh House

EhudZiv

Track 2Ballroom

2:00 PM Genetic control of NOD (nonobese diabetic) CD4+ autoreactive T cell function
The GOTO-Kakizaki Rat, a non-obese genetic model of mild type 2 diabetes: how
2:00 PM mild is mild?
Genetic disassociation of autoimmunity and resistance to costimulation blockage2:25 PM induced transplantation tolerance in NOD mice
Genetics of the development of nutritionally induced hyperglycemia in diabetes
2:15 PM type 2 model

DesireeSchumanTrack 1Walsh House

Ying-HueLee

Track 2

Ballroom

Breaks2:50 PM The Fas pathway is involved in insulin synthesis and is a target of glucotoxicity
Liver-specific reactivation of the inactivated hepatocyte nuclear factor 1 alpha2:30 PM gene: a better mouse MODY3 model
3:00 and
3:10 PM refreshments are available in each track location
RIP-mCD80 transgenic mouse studies as a T1DM model, and the non-human
3:30 PM primate model for islet cell transplantation

DavidHarlan

Track 1Walsh House

Christopher

Newgard

Track 2

Ballroom

Akio

KoizumiTrack 1Walsh House

EleazarShafrir

Track 2

Ballroom

3:30 PM Genetic Engineering to Define New Diabetes Therapies
Unique features of Akita diabetic mouse with special emphasis on the3:55 PM pathogenesis of diabets and its renal complications
Psammomy obesus - Pathophysiology of nutritionally induced insulin resistance
3:55 PM progressing to type 2 diabetes…

MarianneLarsen

Track 1Walsh House

4:20 PM The Gottingen minipig in diabetes researchJohnLeahy

Track 2

Ballroom

4:20 PM ß-cell compensation and failure in partial pancreatectomy rat
5:00 PM Bus leaves Walsh House Parking Lot for Tour of The Jackson Laboratory

Friday

June 20thLinda

WickerTrack 1Walsh House

8:35 AM Immunogenetics of the NOD mouse model

MasamiShinohara

Track 2

Ballroom

8:35 AM The SDT Rat: A New Animal Model of Type 2 Diabetes with Diabetic Retinopathy

NoraSarvetnick

Track 1Walsh House

9:00 AM Regulation of Autoimmunity

Jayne

DanskaTrack 1Walsh House

9:25 AM Genetic Regulation of Type 1 diabetes in NOD and congenic strains

Timothy

Kern

Track 2Ballroom

9:25 AM Diabetic retinopathy in rodents: new studies, new models

ElizabethBlankenhorn

Track 1Walsh House

9:50 AM New Genetic Loci for viral-induced T1DM in the rat

AndersSima

Track 2

Ballroom

9:50 AM Neuropathy and encephalopathy in type 1 BB/Wor and type 2 BB/Z-rats

Break

10:10 AM refreshments are available in each track location

ToruMiyazaki

Track 1Walsh House

MatthewBreyer

Track 2Ballroom

10:30 AM Targeted Disruption of AIM in NOD-derived ES cells
The NIH Animal Models of Diabetes Complications Consortium: mouse models of
10:30 AM diabetic nephropathy

DennisGuberski

Track 1Walsh House

10:55 AM Diabetic rats: Research, Resources and Characteristics

Streamson

Chua

Track 2Ballroom

10:55 AM A novel diabetes congenic strain with diabetic nephropathy

Jennifer

Lowry

Track 1Walsh HouseDavidFink

Track 2Ballroom

11:20 AM The Type 1 Diabetes Repository at The Jackson Laboratory
Gene Therapy for Neuropathy: Neurotrophin gene transfer using herpes vira
11:20 AM vectors in diabetic neuropathy

Linda

WickerTrack 1Walsh House

11:45 AM NIH/Sanger Sequencing Project: Goals & Timetables

Kristin

AbrahamTrack 2Ballroom

11:45 AM NIDDK Mouse Metabolic Phenotyping CentersBallroom

12:05 PM Edenfield Dining Room, one floor above the ballroom
Unraveling Insulin Action and the Pathogenesis of Diabetes Through the Use of
1:20 PM Knockout Mice

Walsh House

1:45 PM Poster Presenters place posters on boards, pins provided

Walsh House

2:00 PMWalsh House

4:00 PMBallroom

6:00 PMBallroom

7:00 PM banquet speaker

Lunch
C. Ronald

Kahn

PosterDouglasColemanPlenary

SessionCocktail
Party
BanquetDinnerBanquetSpeaker