Media separation –––––– Robolux Multiway Diaphragm Valve / Type 2036

Chromatography
without mixingof mediaMedia separation –––––– More quality and efficiency/ Chromatography efficiency / The objective of the chromatography process is clear: At the end, the maximum amountof the sometimes extremely expensive end product shall beextracted. Mixing must be avoided at all costs. Therefore, youneed a system that is easy to rinse and offers an absolute minimum of dead space. Since the demands on product quantity and quality are constantly increasing, plant availability andefficiency must be high. Valves with minimum dead space that
accelerate the process and save time during repair and maintenance activities make a valuable contribution. Since time ismoney.

biopharmaceuticalAcompany constantly
produces high-quality end products – safely and costefficiently. Avoiding the contamination or mixing of media
is the top priority. The demands placed on fluidic systems
and machines are correspondingly high.

Product 1

Product 2

Product 3

Product 4

Do you want to optimise your chromatography process and ensure thequality of the end product? Discover more on the following pages.

Media separation –––––– Challenge/ Precise media separation / Optimise key steps in the chromatography process with detailed solutions, thereby improving product quality and plant efficiency.

The valves

control and distribute the media intoand out of the chromatography column – precisely and efficiently.
ColumnMedium 1

Upstreamprocessing

Medium 2
Cell harvest andproduct separation
Wasteproducts

Medium 3

Chromatography

Product 1

Product 2
Filling

Product 3

Conventional solutions
Valve diverter consisting of four valves in which themedia must travel an inefficiently long distance and thedead space is quadrupled.
Product 4

Block solution with two chambers in whichmedia can mix.

Media separation –––––– Solution

Media separation –––––– Added values/ Media separation with Robolux / Designed for the controlof ultra-pure, sterile and aseptic media, the Robolux Multiway Diaphragm Valve offers the ideal solution for chromatography. The special feature of the patented Robolux technology: The diaphragm actuates two valve seats at the sametime. This avoids dead spaces, reduces the flow volume
while saving time and money.

Robolux
Type 2036

Minimising contaminationOptimum use of production spaceThanks to the Robolux's minimum dead volume and optimised
fluidic design, the chromatography system can be cleaned quickly
and without residue, even with aggressive CIP media. There is no
mixing of media. This helps to prevent follow-up costs and contamination and ensures the quality of the end products.

The extremely compact design provides operators with significantly more space, which speeds up maintenance and repair
activities. By switching from conventional solutions to thecompact Robolux, you increase your output and thus your plant
efficiency – without the need for extra space.

Maximum extraction of the end productIn order for you to be able to extract the maximum possibleamount of the sometimes extremely expensive end product at theend of the chromatography process, mixing must be prevented.
You save money through the safe and efficient distribution, extraction and emptying of the columns.

Reducing downtime
The faster you put the plant back into operation after maintenance, the more efficient your capacity utilisation will be. Since
Robolux has two valve seats actuated by one diaphragm, routine
diaphragm change takes only half as long as with, e.g., a conventional solution.

Media separation –––––– Prevent mixing/ No dead space – no mixing / Be it product ingredients, solvents orcleaning agents: If substances remain unintentionally in the deadspace of a valve, it leads to the mixing of media – and thus to consequential costs. By minimising the existing dead volume, you reduce
the risk of product mixing and increase the process speed throughshorter distances.

Examplecalculation

Three fluidic concepts result in three differently sized dead volumes. Your profit is based on
the respective reduction of product mixing. The following example calculation shows potential
savings using a fictitious value of €100,000 per 100 ml of the chromatography end product as
an example.

90 ml = €90,000

dead volume

Conventional valve
distributor

53 ml = €53,000

dead volume

Conventional
block solution

22
dead volume

Bürkert Robolux

ml = €22,000-68ml = €68,000

Media separation –––––– Avoiding plant downtime/ Minimise downtime, increase availability / In contrast to conventional valve solutions with two diaphragms, Robolux works with only one
diaphragm. This saves money on spare parts and time on replacement
and maintenance activities.

Examplecalculation

There are many valves in a chromatography system, the diaphragms of which are usually replaced
once a year. The following calculation illustrates the potential time savings when replacing a
conventional solution with Robolux. In this example, we assume 30 valves in the chromatography
sector for a conventional solution. With Robolux you only need 15 diaphragms.

Conventional solution

Robolux3015diaphragms

Administration
Logistics
Replacement
Quality &documentation

1x1x30 x30 x

9 min
7 min
990 min360 min

Total time required:		

1,366 min23				= almost

T ime re

quir

place
ed to re1 diaphragm

er,tration
Adminis phragm and ordiadtcle(seining)
staff tras
Logistic nd retrieval)a(storage

7 min
33 minries)

ccessoetting ament
bly, sReplace bly and assemm(disasseentation& docum on, evaluation
Quality
ticragm)g inspee diaph(receivinon of thtitaneum
and doc
Total

9 min

12 min61 minAdministration
Logistics
Replacement
Quality &documentation

1x
1x
15 x
15 x

Total time required:		

9 min
7 min
495 min180 min

961 min11.5		
hours

Maintenance savings 11.5 hours =Robolux
Sectional modeldiaphragms= almost

1½

working dayshours

894578 | Version 07/2019 | Printed 07/2019

Media separation

Bürkert Fluid Control Systems
Christian-Bürkert-Straße 13 –1774653 Ingelfingen
Germany
Phone: +49 7940 100
Fax: +49 7940 1091204
info@burkert.com
www.burkert.com