日補綴会誌

8・125 回特別号，2016

第 1 日 第 2 会場
課題口演発 表⺖㗴㪈ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䈏೨㗡೨㊁䈱ᵴേ䈮ਈ䈋䉎ᓇ㗀䂾ᯫ၂ቱ᣿䋬ᓟ⮮ፏ᥍䋬ᏒᎹື㓶

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ᓼፉᄢቇᄢቇ㒮කᱤ⮎ቇ⎇ⓥㇱญ⣧㗶㗻㕙⵬✄ቇಽ㊁
Effect of periodontal tactile sensation on activation of prefrontal cortex
Higaki N, Goto T, Ichikawa T
Department of Oral and Maxillofacial Prosthodontics Institute of Biomedical Sciences, Tokushima
University Graduate School㸇䋮㩷⋡⊛䇭㜞㦂⠪䉇⹺⍮∝ᖚ⠪䈱Ⴧട䈮઻䈦䈩䋬⹺⍮ᯏ⢻䈱⛽ᜬ䈏ᵈ⋡䈘䉏䈩䈍䉍䋬䈠䈱ਛ䈪⹺⍮ᯏ⢻䉕ม䉎೨㗡೨㊁䈱㊀ⷐᕈ䈏ᜰ៰䈘䉏䈩䈇䉎1㪀䋮೨㗡೨㊁䈲ⶄ㔀䈭⹺⍮ⴕേ⸘↹䉇ᗧᕁ᳿ቯ䉕೙ᓮ䈜䉎㗔ၞ䈪䈅䉎䋮䉁䈢䋬᭽䇱䈭ᧃ᪳䈎䉌䈱ᗵⷡᖱႎ䈱⛔ว䈮ኻ䈚䈩㊀ⷐ䈭ᓎഀ䉕ᨐ䈢䈚䈩䈇䉎䋮䈚䈎䈚䋬⵬✄ᱤ⑼ᴦ≮䈍䉋䈶๰ྨᯏ⢻䈮䈫䈦䈩ᭂ䉄䈩㊀ⷐ䈪䈅䉎䈫⠨䈋䉌䉏䉎ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䈫೨㗡೨㊁䈱ᵴേ䈫䈱㑐ㅪ䈲੹ᣣ䉁䈪ᬌ⸛䈘䉏䈩䈇䈭䈇䋮ᧄ⎇ⓥ䈪䈲䋬ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䈫ᄖㇱᖱႎ䈮䉋䉎⛔ว䈏ຏวജ䈱⛽ᜬ⢻䈫೨㗡೨㊁䈱ᵴേ䈮ਈ䈋䉎ᓇ㗀䉕᣿䉌䈎䈮䈜䉎䈖䈫䉕⋡⊛䈫䈚䈢䋮
䇭㸈䋮㩷ᣇᴺ䇭ⵍ㛎⠪䈲㗶ญ⣧♽䈱⇣Ᏹ䈫䋬⣖ⴊᵹ䈮ᓇ㗀䉕ਈ䈋䉎ⷐ࿃䈫䈭䉎∔∛䈱ᣢᓔ䉕⹺䉄䈭䈇ஜᏱ᦭ᱤ㗶⠪5
ฬ䋨↵ᕈ4ฬ䋬ᅚᕈ1ฬ䋬ᐔဋᐕ㦂26㪅0㫧1㪅4ᱦ䋩䈫䈚䈢䋮ታ㛎䉺䉴䉪䈫䈚䈩䋬ᜰ␜䈚䈢ຏวജ䉕⛽ᜬ䈘䈞䉎㵰ຏวജ⛽ᜬ⢻㵱䉕⸳ቯ䈚䈢䋮ຏวജ⛽ᜬਛ䈱೨㗡
೨㊁䈱⣖ⴊᵹ㊂䈲䋬䉡䉢䉝䊤䊑䊦శ䊃䊘䉫䊤䊐䉞䊷
䋨WOT㪄100䋬HITACHI䋬᧲੩䋩䉕↪䈇䈩᷹ቯ䈚䈢䋮᷹ቯㇱ૏䈲10㊁䋬46㊁ฝ䋬46㊁Ꮐ䈱3䈎ᚲ䈫䈚䋬ຏวജ䈫หᤨ䈮⣖ⴊᵹ㊂䉕᷹ቯ䈚䈢䋮ⵍ㛎ᱤ䈲਄ਅᏀ஥╙৻ᄢ⥓ᱤ䈫䈚䋬ຏว㕙㑆〒㔌䈏5㩷mm䈪ຏว䈪䈐䉎䉋䈉䈮⺞ᢛ䈚䈢䊨䊷䊄䉶䊦䋨UNCDW㪄200N䋬Unipulse㪃᧲੩䋩䉕↪䈇䈩ຏวജ䉕᷹ቯ䈚䈢䋮ᜰ␜䈚䈢ຏวജ䈲
25 䌾 30㩷 N 䈫 䈚 䋬 䊂 䉳 䉺 䊦 䉟 䊮 䉳 䉬 䊷 䉺 䋨 F372A 䋬
Unipulse㪃㩷᧲੩䋩䈮⴫␜䈘䉏䉎ຏวജ୯䉕⷗䈞䈩2ಽ㑆✵⠌䈘䈞䈢ᓟ䋬ฦ᷹ቯᤨ䈮䈲⴫␜䉕⷗䈞䈝30⑽ຏ
วജ䉕⛽ᜬ䈜䉎䉋䈉ᜰ␜䈚䈢䋮ຏวജ⛽ᜬਛ䈱ᄖㇱᖱႎ䈫䈚䈩ⷞⷡᖱႎ䋨ᜰ␜ຏวജ▸࿐ᄖ䋬▸࿐ౝ䉕
LED䈪⴫␜䋩䈫⡬ⷡᖱႎ䋨䊑䉱䊷䈱䉥䊮䉥䊐䋩䉕⸳ቯ䈚䈢䋮ⷞⷡᖱႎઃਈ⟲䋬⡬ⷡᖱႎઃਈ⟲䈮ട䈋䈩䋬ᄖㇱᖱႎ䉕ઃਈ䈚䈭䈇䉮䊮䊃䊨䊷䊦⟲䈫䋬ຏวജ䈱⺞▵䉅ⴕ䉒䈞䈭䈇቟㕒ᤨ⟲䈱4⟲䉕⸳ቯ䈚䈢䋮ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䈱᦭ή䈮㑐䈚䈩䈲䋬ⵍ㛎ᱤઃㄭ䈮ዪᚲ
㤗㈮䉕ᣉⴕ䈘䈞䈢⟲䈫ᣉⴕ䈘䈞䈭䈎䈦䈢⟲䈱2⟲䉕⸳ቯ䈚䋬ਔ⟲䈫䉅਄⸥䈱䉺䉴䉪䉕ⴕ䉒䈞䈢䋮ᧄታ㛎䈲ᓼፉᄢቇ∛㒮⥃ᐥ⎇ⓥ୶ℂክᩏᆔຬળ䈱ᛚ⹺䋨ᛚ⹺⇟ภ䋺1780䋩䉕ᓧ䈩ⴕ䈦䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ䇭ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䉕༚ᄬ䈘䈞䈢㤗㈮䈅䉍⟲䈲
㤗㈮䈭䈚⟲䈫Ყセ䈚䈩⣖ⴊᵹ㊂䈏᦭ᗧ䈮ᷫዋ䈚䈩䈇䈢䋨࿑䋩䋮ຏวജ䈱ታ᷹୯䈮㑐䈚䈩䋬㤗㈮䈅䉍⟲䋬㤗㈮䈭䈚⟲䈫䉅䈮ⷞⷡᖱႎઃਈ⟲䋬⡬ⷡᖱႎઃਈ⟲䈮䈍䈇䈩ຏวജ䈲ᜰ␜䈚䈢▸࿐ౝ䈮෼᧤䈚䋬ᄖㇱᖱႎ䉕ઃਈ䈚䈭䈎䈦䈢䉮䊮䊃䊨䊷䊦⟲䈮䈍䈇䈩䈲ᜰ␜䈚䈢▸࿐䈱ਅ㒢䉋䉍ૐ䈇୯䉕␜䈚䈢䈏䋬䈇䈝䉏䈱⟲㑆䈮䈍䈇䈩䉅᦭ᗧ䈭Ꮕ䈲⹺䉄䉌䉏䈭䈎䈦䈢䋮ຏวജ䈱ᄌേଥᢙ䈮㑐䈚䈩䈲䋬㤗㈮䈅䉍⟲䋬㤗㈮䈭䈚⟲䈫䉅䈮ᄖㇱᖱႎ䉕ઃਈ䈚䈭䈎䈦䈢⟲䈱ᄌേଥᢙ䈏ᦨ䉅㜞䈒䋬ᰴ䈇䈪⡬ⷡᖱႎઃਈ⟲䋬ⷞⷡᖱႎઃਈ⟲䈱㗅䈫䈭䉍䋬ᄖㇱᖱႎ䈱ઃਈ䈮䉋䉍ຏวജ䈲቟ቯ䈜䉎௑ะ䈏⹺䉄䉌䉏䈢䋮䇭એ਄䈱⚿ᨐ䉋䉍䋬ᱤᩮ⤑䈎䉌䈱ᗵⷡᖱႎ䈱᦭ή䈫ᄖㇱᖱႎ䈲ຏวജ䈱⛽ᜬ⢻䈮෸䈿䈜ᓇ㗀䈲ዋ䈭䈇䈏䋬೨㗡೨㊁䈱ᵴേჇട䈮䈫䈦䈩䈲ᔅⷐ䈪䈅䉍䋬⹺⍮ᯏ⢻䈮ᄢ䈐䈒ᓇ㗀䉕ਈ䈋䉎㊀ⷐ䈭ⷐ⚛䈪䈅䉎䈖䈫䈏␜
ໂ䈘䉏䈢䋮
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1䋩 Kawashima R, Okita K, Yamazaki R, Tajima N,
Yoshida H, Taira M, et al. Reading aloud andarithmetic calculation improve frontal functionof people with dementia. J Gerontol A Biol Sci
Med Sci 2005; 60: 380-384.

ຏวജ⛽ᜬ䈍䉋䈶቟㕒ᤨ䈮䈍䈔䉎10㊁䈱⣖ⴊᵹ䈱ᄌൻ㊂䇭─ 113 ─

第 1 日 第 2 会場

日補綴会誌

8・125 回特別号，2016

課題 口 演 発 表⺖㗴㪉ᣣਛ䈱๰ྨ╭╭㔚࿑䊋䉟䉥䊐䉞䊷䊄䊋䉾䉪⸠✵䈏⌧⌁ᤨ䈱⣖ᵄ䈮෸䈿䈜ᓇ㗀䂾ᄢႦ⧷⒤䋬૒⮮㓷੺䋬ᢧ⮮ዊᄐ䋬ᷰㆺ䇭᣿䋬ጤἑ⋥᮸䋬⮮↰ፏผ䋬ศ↰᦭㉿䋬⮮Ỉ᡽♿

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᣿ᶏᄢቇᱤቇㇱᯏ⢻଻ሽ࿁ᓳቇ⻠ᐳᱤ⑼⵬✄ቇಽ㊁
Effect of Daytime Biofeedback Training on Sleep Electroencephalograms
Otsuka H, Sato M, Saito K, Watanabe A, Iwase N, Fujita T, Yoshida Y, Fujisawa M
Division of Fixed Prosthodontics, Department of Restorative & Biomaterials Sciences, Meikai University
School of Dentistry㸇䋮㩷⋡⊛䇭ᤓ੹䋬㗶㑐▵∝䈱⊒∝ේ࿃䉕฽䉄᭽䇱䈭㗶ญ⣧♽䈻䈱ᑷኂ䈫䈚䈩ⷡ㉕ᤨ䊑䊤䉨䉲䉵䊛䋨Awake㩷Bruxism㪑
AB䋩䈍䉋䈶⌧⌁ᤨ䊑䊤䉨䉲䉵䊛䋨Sleep㩷Bruxism㪑㩷SB䋩䈱㑐ਈ䈏ႎ๔䈘䉏䈩䈇䉎䋮ㄭᐕ䋬AB䈮ኻ䈜䉎๰ྨ╭╭ 㔚 ࿑ 䊋 䉟 䉥 䊐 䉞 䊷 䊄 䊋 䉾 䉪 䋨 Electromyogram
Biofeedback㪑㩷EMG㪄BF䋩⸠✵䈱᦭ലᕈ䉇AB䈮ኻ䈜䉎EMG㪄BF⸠✵䈏AB䋬SB䈮ኻ䈚䈩ᛥ೙ലᨐ䉕⹺䉄䈢䈫䈇䈉ႎ๔1䋩䈏䈭䈘䉏䈩䈍䉍䋬䈠䈱᦭ലᕈ䈏⏕⹺䈘䉏䈩䈇䉎䋮৻ᣇ䋬⌧⌁කቇ㗔ၞ䈪䈲䋬SB⊒↢䈏⌧⌁䈱⾰䈮෸䈿䈜ᓇ㗀䈮䈧䈇䈩ႎ๔䈏䈭䈘䉏䈩䈇䉎䋮䈠
䈖䈪AB䈮ኻ䈜䉎EMG㪄BF⸠✵䈏䋬ᄛ㑆⌧⌁ᤨ䈱⣖ᵄ䈮෸䈿䈜ᓇ㗀䉕⺞䈼䉎⋡⊛䈪ᧄታ㛎䉕ⴕ䈦䈢䋮䇭㸈䋮㩷ᣇᴺ䇭䉝䊜䊥䉦⌧⌁කቇળ䈱⌧⌁㓚ኂ࿖㓙ಽ㘃䋨ICSD㪄2䋩䉕ၮ䈮૞ᚑ䈚䈢䉝䊮䉬䊷䊃䉕৻⥸ᄢቇ↢䈮㈩Ꮣ䈚䈢䋮࿁╵䉕ᓧ䉌䉏䈢⠪䈱ਛ䈎䉌ㆡᩰၮḰ䋬㒰ᄖၮḰ䈮ᾖว䈚䋬ஜᏱᚑੱ↵ᕈ8ฬ䋨ᐔဋᐕ㦂22㪅6㫧0㪅7ᱦ䋩䉕ⵍ㛎⠪䈫䈚䈩ㆬᛯ䈚䈢䋮EMG㪄BF⟲䈍䉋䈶䉮䊮䊃䊨䊷䊦
䋨CO䋩⟲䈮ᝄ䉍ಽ䈔ታ㛎䉕ⴕ䈦䈢䋮ታ㛎䉴䉬䉳䊠䊷䊦䉕࿑䈮␜䈜䋮䉁䈢䋬ⵍ㛎⠪䈲ICSD㪄2䈱ၮḰ䈮ᓥ䈇SB
⸻ᢿ䈚䋬ታ㛎㐿ᆎ೨䈮ᄛ㑆⌧⌁ᤨ䊘䊥䉸䊛䊉䉫䊤䊐
䋨PSG䋩䈮䈩SB䈱⁁ᘒ䉕⏕⹺䈚䈢䋮ᧄ⎇ⓥ䈲᣿ᶏᄢቇᱤቇㇱ୶ℂᆔຬળ䈱ᛚ⹺䋨No㪅A1404䋩䉕ᓧ䈩ታᣉ䈚䈢䋮
䇭PSG䈪䈲䋬⣖ᵄ䋬ᔃ㔚࿑䋬㗶ੑ⣻╭╭㔚࿑䋬஥㗡╭╭㔚࿑䋬⌒㔚࿑䋬૕േ䋬๭ๆ䋬SPO2䉕᷹ቯ䈚䋬㖸ჿ
㍳㖸䈍䉋䈶䊎䊂䉥᠟ᓇ䉕ⴕ䈦䈢䋮⣖ᵄ᷹ቯ䈮㓙䈚䋬࿖㓙10㪄20ᴺ䈱㔚ᭂ⾍ઃ૏⟎䈮ၮ䈨䈐C3㪄A2䋬O2㪄
A1䈮㔚ᭂ䉕⾍ઃ䈚䈢䋮PSG᷹ቯ䈮䉋䉍ᓧ䉌䉏䈢⣖ᵄ䊂䊷䉺䈮ኻ䈚䋬ᄙ↪ㅜ↢૕ᖱႎ⸃ᨆ䊒䊨䉫䊤䊛
䋨BIMUTAS㸈䋩䉕↪䈇㜞ㅦ䊐䊷䊥䉣ᄌ឵䈚䋬๟ᵄᢙ⸃ᨆ䉕ⴕ䈇䋬㱐ᵄ䋬㱍ᵄ䈱฽᦭₸䉕▚಴䈚䈢䋮
䇭EMG᷹ቯ䈍䉋䈶EMG㪄BF⸠✵䈮䈲៤Ꮺဳ╭㔚⸘䉕૶↪䈚ή᜔᧤䈪ᣣᏱ↢ᵴⅣႺਅ䈮䈍䈔䉎᷹ቯ䉕3ㅳㅪ⛯䈪ⴕ䈦䈢䋮EMG㪄BF⸠✵䈲1ㅳ⋡䉕䊔䊷䉴䊤䉟䊮䊂䊷䉺㩿week1㪀䈫䈚䋬Watanabe䉌䈱ᣇᴺ2䋩䈮Ḱ䈛BF
㑣୯䉕⸳ቯ䈚䈢䋮2ㅳ⋡㩿week2㪀䈱ㅪ⛯䈚䈢2ᣣ㑆䈮㑣୯એ਄䈱╭ᵴേ䉕ᬌ಴䈚䈢㓙䈮㔚ሶ㖸䈏㡆䉎䉋䈉䈮⸳ቯ䈚䈢䋮ⵍ㛎⠪䈮䈲䋬䇸㔚ሶ㖸䈏㡆䈦䈢䉌䈒䈇䈚䈳䉍䉕ᱛ䉄䉎䉋䈉䇹ᜰ␜䈚䈢䋮䈘䉌䈮䋬⸠✵ታᣉ䈱⠉ㅳ
㩿week3㪀䈮BF䉕ⴕ䉒䈝EMG䉕᷹ቯ䈚䈢䋮EMG⸃ᨆ䈮䈲䋬᷹ቯ㐿ᆎᤨ䈮ᦨᄢຏ䉂䈚䉄䉕ⴕ䉒䈞䈢㓙䈱䋬╭ᵴേ㊂䉕100䋦MVC䈫䈚䈩⋧ኻ⊛䈮⹏ଔ䈚䈢䋮୘ੱ䈗䈫䈮⸳ቯ䈚䈢䋬㑣୯䉕⿥䈋䈢EMG䉟䊔䊮䊃ᢙ䉕䊑䊤䉨䉲䉵䊛䉟䊔䊮䊃䈫䈚䈩▚಴䈚䈢䋮䉁䈢䋬ਥⷰ⊛䈭䊂䊷䉺䈫䈚䈩ታ㛎㐿ᆎ೨ᓟ䈮䈍䈇䈩䋬ᔃℂ䊁䉴䊃䋨MAS䋩䈍䉋䈶䊏䉾䉿䊋䊷䉫⌧⌁⾰໧␿䋨PSQI䋩䉕ታᣉ䈚䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ䇭⣖ᵄ䈱⸃ᨆ䈮䈍䈇䈩䋬EMG㪄BF⟲䈮䈍䈇䈩week1䈮Ყセ䈚䈩䋬week2䋬week3䈮䈍䈇䈩㱍ᵄ䈱᦭ᗧ䈭ᷫዋ䉕⹺䉄䈢䋮䉁䈢䋬⛔⸘ቇ⊛䈭᦭ᗧᏅ䈲⹺䉄䉌䉏䈭䈇䉅䈱䈱䋬week1䈮Ყセ䈚䋬week3䈪䈲㱐ᵄ䈏Ⴧട䈚䈢䋮䉁䈢䋬EMG⸃ᨆ䈮䈍䈇䈩Sato䉌䈱ႎ๔1䋩䈫ห᭽䈮
EMG㪄BF⟲䈪䈲week1䈮Ყ䈼week3䈪䈲SB䉟䊔䊮䊃䈱ᷫዋ௑ะ䈏⏕⹺䈪䈐䈢䋮㩷PSQI䈮䈍䈇䈩䋬BF⟲䈪⌧⌁㓚ኂ䉕⹺䉄䈢ⵍ㛎⠪䈏BF⸠✵೨䈪䈲3ฬ䈪䈅䈦䈢䈏䋬BF⸠✵ᓟ䈮䈲1ฬ䈫ᷫዋ䈚䈢䋮MAS䈮䈍䈇䈩䈲䋬EMG㪄BF⟲䋬CO⟲䈫䉅ታ㛎೨ᓟ䈪․ᓽ⊛䈭ᄌൻ䈲⏕⹺䈪䈐䈭䈎䈦䈢䋮䇭એ਄䈱⚿ᨐ䈎䉌䋬ᣣਛ䈱EMG㪄BF⸠✵䈲䊑䊤䉨䉲䉵䊛ᛥ೙䈱䉂䈭䉌䈝䋬⌧⌁䈱⾰䈱ᡷༀ䈮䉅᦭ല䈭ᴦ
≮ᴺ䈫䈭䉎น⢻ᕈ䈏␜䈘䉏䈢䋮䇭㸊䋮㩷ᢥ₂
1䋩 Sato M, Iizuka T, Watanabe A, Iwase N, Otsuka
H, Terada N et al. Electromyogram biofeedback
training for daytime clenching and its effect on
sleep bruxism. J Oral Rehabil 2015; 42: 83-89
2䋩 Watanabe A, Kanemura K, Tanabe N, Fujisawa
M. Effect of electromyogram biofeedback on
daytime clenching behavior in subjects withmasticatory muscle pain. J Prosthodont Res 2011;55: 75-81࿑䇭ታ㛎䉴䉬䉳䊠䊷䊦䇭

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課題口演発 表⺖㗴㪊╭⪜❗ᕈ஥⚝⎬ൻ∝ᖚ⠪䈱៨㘩ྚਅᯏ⢻⹏ଔ䈮䈍䈔䉎⥠࿶ᬌᩏ䈱᦭↪ᕈ䂾ᐔጟ䇭✍ 㪈㪀䋬Ყཅජ੝Ꮖ 㪈㪀䋬᫪䇭㓉ᶈ 㪈㪀䋬ਣጊ⌀ℂሶ 㪈㪀䋬㜟ᧁᐘሶ 㪉㪀䋬ศᎹፄട 㪈㪀䋬ศ↰శ↱ 㪈㪀䋬ᵤ⾐৻ᒄ 㪈㪀
㪈㪀ᐢፉᄢቇᄢቇ㒮කᱤ⮎଻ஜቇ⎇ⓥ㒮䇭ᔕ↪↢๮⑼ቇㇱ㐷䇭వ┵ᱤ⑼⵬✄ቇ⎇ⓥቶ䋬 㪉㪀ᓸ㘑ળ䊎䊊䊷䊤⧎䈱㉿∛㒮
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Diagnostic value of maximum tongue pressure measurement for swallowing dysfunction in amyotrophic
lateral sclerosis patients
Hiraoka A 1), Higa C 1), Mori T 1), Mruyama M 1), Takaki S 2), Yoshikawa M 1), Yoshida M 1), Tsuga K 1)
1)
Department of Advanced Prosthodontics, Applied Life Sciences, Institute of Biomedical & Health
Sciences, Hiroshima University, 2)Mifukai Vihara Hananosato Hospital㸇䋮㩷⋡⊛䇭╭⪜❗ᕈ஥⚝⎬ൻ∝䋨ALS䋩䈲ㅴⴕᕈ䈱␹⚻ᄌᕈ∔ᖚ䈪䈅䉍䋬ਥ∝⁁䈱৻䈧䈮៨㘩ྚਅ㓚ኂ䈏᜼䈕䉌䉏䉎䋮ㄭᐕ䋬៨㘩ྚਅ㓚ኂ䈱⹺䉄䉌䉏䈢ALSᖚ⠪䈱ᦨᄢ⥠࿶䈲䋬⹺䉄䉌䉏䈭䈎䈦䈢⠪䉋䉍ૐ୯䈪䈅䈦䈢䈖
䈫1䋩䋬ALS䈱∛ᘒ䈱ㅴⴕ䈮઻䈇ᦨᄢ⥠࿶䈏ૐਅ䈚䈢䈖
䈫2䋩䈏ႎ๔䈘䉏䈩䈇䉎䉅䈱䈱䋬ALSᖚ⠪䈱៨㘩ྚਅ㓚ኂ䈱ᣧᦼ⊒⷗䈫ኻᔕᣇᴺ䈲ᧂ䈣⏕┙䈘䉏䈩䈇䈭䈇䋮䈠䈖䈪ᧄ⎇ⓥ䈪䈲䋬ALSᖚ⠪䈱ᦨᄢ⥠࿶䈫៨㘩ྚਅᯏ⢻䈫䈱㑐ଥ䉕⚻ᤨ⊛䈮ᬌ⸛䈜䉎䈖䈫䈮䉋䉍䋬ALSᖚ⠪䈱៨㘩ྚਅᯏ⢻⹏ଔ䈫ኻᔕ䈮䈍䈔䉎⥠࿶ᬌᩏ䈱᦭↪ᕈ䈮䈧䈇䈩᣿䉌䈎䈮䈜䉎䈖䈫䉕⋡⊛䈫䈚䈢䋮䇭㸈䋮㩷ᣇᴺ䇭ኻ⽎⠪䈲྾⢇㤗∽⊒∝ဳALSᖚ⠪25ฬ䋨↵ᕈ11
ฬ䋬ᅚᕈ14ฬ䋬ᐔဋᐕ㦂䋺61㪅8㩷㫧㩷9㪅5ᱦ䋩䈫䈚䋬ᦨᄢ⥠࿶䋬ᡷ⸓ALSᯏ⢻⹏ଔ䉴䉬䊷䊦䈱⃿㤗∽䉴䉮䉝䉕▚಴䈜䉎䈫䈫䉅䈮䋬ྚਅㅧᓇᬌᩏ䋨VF䋩䉕ታᣉ䈚䋬ㅧᓇ೷౉䉍䊣䊷䉫䊦䊃3㪅0㩷gྚਅᤨ䈱ญ⣧䈍䉋䈶ຜ㗡ౝᱷ⇐䈱᦭ή䋬⥠ᯏ⢻ૐਅ䈱᦭ή䋬ญ⣧ㅢㆊᤨ㑆䋨OTT䋩䈭䉌䈶䈮ຜ㗡ㅢㆊᤨ㑆䋨PTT䋩䉕⹏ଔ䈚䈢䋮⛔⸘ቇ⊛ᬌ⸛䈲䋬ญ⣧䈍䉋䈶ຜ㗡ౝᱷ⇐䈭䉌䈶䈮⥠ᯏ⢻ૐਅ䈱᦭ή䈮䉋䉎ᦨᄢ⥠࿶䈱Ყセ䈮Mann㪄Whitney㩷Uᬌቯ䉕ⴕ䈇䋬ຜ㗡ౝᱷ⇐䈫⥠ᯏ⢻ૐਅ䈮ᓇ㗀䉕ਈ䈋䉎ⷐ࿃䉕ᄙ㊀䊨䉳䉴䊁䉞䉾䉪࿁Ꮻಽᨆ䈮䉋䉍᛽಴䈚䈢䋮ᦨᄢ⥠ ࿶ 䈫 OTT 䈍 䉋 䈶 PTT 䈱 ⋧ 㑐 㑐 ଥ 䈱 ⹏ ଔ 䈮 䈲
Spearman䈱㗅૏⋧㑐ଥᢙ䋨㱝䋩䉕↪䈇䈢䋮䉁䈢䋬ROCᦛ✢䉋䉍⃿㤗∽䉴䉮䉝䈏ૐਅ䈜䉎ᦨᄢ⥠࿶䈱䉦䉾䊃䉥䊐୯䉕▚಴䈚䈢䋮
䇭ᰴ䈇䈪䋬ㅊ〔น⢻䈪䈅䈦䈢16ฬਛ䋨↵ᕈ7ฬ䋬ᅚᕈ9ฬ䋬ᐔဋᐕ㦂䋺61㪅8㩷㫧㩷8㪅8ᱦ䋩䋬⸳ቯ䈚䈢ᦨᄢ⥠࿶䈱䉦䉾䊃䉥䊐୯䉕⛽ᜬ䈚䈩䈇䈢⠪䈫䈠䉏એᄖ䈱⠪䈮䈍䈔䉎⃿㤗∽∝⁁䈱⊒⃻₸䈱ᬌ⸛䈮㱣2ᬌቯ䉕↪䈇䈢䋮䈘䉌䈮䋬㘩ᒻᘒ䈱ᄌᦝ䉇⢗≪ㅧ⸳䈏䈭䈘䉏䈢ᤨᦼ䉕⺞ᩏ䈚䋬ᦨᄢ⥠࿶䈱䉦䉾䊃䉥䊐୯䈮䉋䉍䈖䉏䉌䈏䈬䈱⒟ᐲ
੍᷹䈪䈐䉎䈎ᗵᐲ䈫․⇣ᐲ䉕᳞䉄ᬌ⸛䈚䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ䇭ᦨᄢ⥠࿶䈲ຜ㗡ౝᱷ⇐䈱⹺䉄䉌䉏䈢⠪䈍䉋䈶⥠ᯏ⢻䈱ૐਅ䈚䈢⠪䈪ૐ䈇୯䉕␜䈚䋨P㩷㪓㩷0㪅01䋩䋬ᄙ㊀䊨䉳
䉴䊁䉞䉾䉪࿁Ꮻಽᨆ䈱⚿ᨐ䈎䉌䋬ᦨᄢ⥠࿶䈲ຜ㗡ౝᱷ⇐䈍䉋䈶⥠ᯏ⢻ૐਅ䈮ᓇ㗀䉕෸䈿䈜࿃ሶ䈪䈅䉎䈖䈫䈏᣿䉌䈎䈫䈭䈦䈢䋮䉁䈢䋬ᦨᄢ⥠࿶䈫OTT䋨㱝㩷 㪔㩷 −0㪅64㪃㩷 P㩷㪓㩷0㪅01䋩䋬ᦨᄢ⥠࿶䈫PTT䋨㱝㩷㪔㩷−0㪅64㪃㩷P㩷㪓㩷0㪅
01䋩䈱㑆䈮⽶䈱⋧㑐䉕⹺䉄䈢䋮ᦨᄢ⥠࿶䈲⃿㤗∽∝⁁䈱䈅䉎⠪䈪ૐਅ䈚䈩䈍䉍䋨P㩷㪓㩷0㪅01䋩䋬⃿㤗∽∝⁁䈏⊒⃻䈜䉎㓙䈱ᦨᄢ⥠࿶䈱䉦䉾䊃䉥䊐୯䈲21㪅0㩷kPa䈪䈅䈦䈢䋮䇭ㅊ〔ਛ䋬ᦨᄢ⥠࿶䈏䉦䉾䊃䉥䊐୯䉕ਅ࿁䈦䈢⠪䈪䈲䋬⃿㤗∽∝⁁䈏⊒⃻䈚䈩䈇䉎⠪䈏ᄙ䈇䈖䈫䈏␜䈘䉏
䈢䋨P㩷㪓㩷0㪅01䋩䋮䈘䉌䈮䋬ᦨᄢ⥠࿶䈏䉦䉾䊃䉥䊐୯䉕ਅ࿁䈦䈢႐ว䋬䈠䈱⚂4䊰᦬ᓟ䈮㘩ᒻᘒᄌᦝ䉇⢗≪ㅧ⸳䈫䈭䉎䊥䉴䉪䉕ᗵᐲ67㩷㩼䋬․⇣ᐲ90㩷㩼䈪್೎䈜䉎䈖䈫䈏䈪䈐䈢䋮䈖䈱䈖䈫䈲䋬ᦨᄢ⥠࿶䈏21㪅0㩷kPaએ਄䈱ᖚ⠪䈪䈲䋬⃿㤗∽∝⁁䈱⊒⃻䈲䈅䉁䉍⹺䉄䉌䉏䈝⚻ญ៨ข䈮䈧䈇䈩೎Ბ⠨ᘦ䈜䉎ᔅⷐ䈲䈭䈇䉅䈱䈱䋬21㪅0kPa䉕ਅ࿁䉎ᤨᦼ䈎䉌⃿㤗∽∝⁁䈏ᖡൻ䈚䋬㘩ᒻᘒ䈱ᄌᦝ䉇⢗≪ㅧ⸳䈫䈇䈦䈢ᩕ㙃៨ข਄䈱ኻᔕ䉕⠨䈋䉎ᔅⷐ䈏↢䈛䉎䈖䈫䉕␜ໂ䈚䈩䈇䉎䋮䇭એ਄䈱⎇ⓥ⚿ᨐ䉋䉍䋬ᦨᄢ⥠࿶䈲ALSᖚ⠪䈱៨㘩ྚਅᯏ⢻ૐਅ䉕੍᷹䈜䉎ᜰᮡ䈫䈭䉍ᓧ䉎䈖䈫䈏᣿䉌䈎
䈫䈭䉍䋬ALSᖚ⠪䈱៨㘩ྚਅᯏ⢻⹏ଔ䈮⥠࿶ᬌᩏ䈲᦭↪䈪䈅䉎䈖䈫䈏␜䈘䉏䈢䋮䇭㸊䋮㩷ᢥ₂
1䋩 Morimoto N, Yamashita T, Sato K et al.
Assessment of swallowing in motor neuron
disease and Asidan/SCA36 patients with new
methods. J Neurol Sci 2013; 324: 149-155.
2䋩 Easterling C, Antinoja J, Cashin S et al. Changes
in tongue pressure, pulmonary function, andsalivary flow in patients with amyotrophic lateralsclerosis. Dysphagia 2013; 28: 217-225.

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課題 口 演 発 表⺖㗴㪋ᱤ䈱༚ᄬ䈏㜞ᰴ⣖䈮෸䈿䈜ᓇ㗀
VBM䉕↪䈇䈢⣖ኈⓍ䈱ቴⷰ⊛⹏ଔ䇭䂾ਭ଻↰዁ผ䋬ዊᨋ℉਽䋬ᰞᐸᶈਯ䋬ਛ㉿ᢥ㚅䋬㊁᧛ᄥ㇢䋬ㄭ⮮ዏ⍮
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ጤᚻක⑼ᄢቇᱤቇㇱ⵬✄䊶䉟䊮䊒䊤䊮䊃ቇ⻠ᐳEffect of tooth loss is on the higher brain
Objective assessment of brain volume using the VBM
Kubota M, Kobayashi T, Sakuraba H, Nakasato A, Nomura T, Kondo H
Department of Prosthodontics and Oral Implantology, Iwate Medical University㸇䋮㩷⋡⊛䇭਎⇇ਛ䈪㜞㦂ൻ䈏ㅴ䉃ਛ䋬ⷐ੺⼔⠪ᢙ䈱Ⴧട䈱ේ࿃䈫䈭䉎⹺⍮∝䈏ᄢ䈐䈭໧㗴䈫䈭䈦䈩䈇䉎䋮ෘ↢ഭ௛⋭䈱⺞ᩏ⚿ᨐ䈮䉋䉎䈫䋬⹺⍮∝䈲੺⼔䈏ᔅⷐ䈮䈭䈦䈢ේ࿃䈱15㪅3䋦䉕භ䉄䋬⣖තਛ䋨21㪅5䋦䋩䈮ᰴ䈇䈪2⇟⋡䈮ᄙ䈇䋮65ᱦએ਄䈱㜞㦂⠪䈱䈉䈤⹺⍮∝䈱ੱ䈱ഀว䈲15䋦䈫䈘䉏䋬2025ᐕ䈮䈲700ਁੱ䉕⿥䈋5ੱ䈮
1ੱ䈲⹺⍮∝䈮⟕ᖚ䈜䉎䈫ផ⸘䈘䉏䈩䈇䉎䋮䇭ᄙ䈒䈱ᮮᢿ⎇ⓥ䈮䉋䈦䈩⹺⍮∝ᖚ⠪䈱ญ⣧䈲ਇ⦟䈪䈅䉎䈖䈫䈏␜䈘䉏䋬⹺⍮∝ᖚ⠪䈲ஜᏱ⠪䉋䉍䉅䈉ⲁ䋬༚ᄬᱤ䋬ᱤ๟∛䈏ᄙ䈒䋬⟵ᱤ䈏ਇ቟ቯ䈪䋬ญ⣧ᷡ᝹⁁ᘒ䈏ਇ⦟䈪䈅䉎䈖䈫䈏ႎ๔䈘䉏䈩䈇䉎䋮䈚䈎䈚䋬⹺⍮∝䈮䈭䈦䈢⚿ᨐ䈫䈚䈩ญ⣧䈏ਇ⦟䈮䈭䈦䈢䈱䈎䋬ญ⣧ౝ䈱⁁ᘒ䈏䈠䈱ᓟ䈱⹺⍮∝䈱⊒∝䉇ᯏ⢻ૐਅ䈮ᓇ㗀䉕෸䈿䈚䈢䈱䈎䋬䈖䉏䉁䈪䈱ᮮᢿ⎇ⓥ䈎䉌䈲䈠䈱࿃ᨐ㑐ଥ䈲᣿䉌䈎䈮䈘䉏䈩䈇䈭䈇䋮䇭৻ᣇ䋬ᱤ䈱༚ᄬ䈮䉋䈦䈩๰ྨ⢻ജ䈏ૐਅ䈚䋬⣖䈻䈱ೝỗ䈏ዋ䈭䈒䈭䉎䈢䉄䈮䋬⣖䈱⹺⍮㗔ၞ䈱ㅌⴕᕈᄌൻ䈏⿠䈖䉎1䋩䈫䈱ႎ๔䉇䋬ญ⣧ᯏ⢻䈏ᄬ䉒䉏䈩䉅ᯏ⢻䉕࿁ᓳ䈜䉎䈖䈫䈪䋬⣖␹⚻ᵴേ䉅ౣ䈶ᵴᕈ䈘䉏䉎䈫䈱ႎ๔䉅䈅䉎䋮㩷ญ⣧ᯏ⢻䈫⣖ᯏ⢻䈫䈲ኒធ䈮㑐ଥ䈲␜ໂ䈘䉏䈩䈇䉎䈏䋬ᧂ䈣ਇ᣿䈭ὐ䈏ᄙ䈇䋮䈠䈖䈪䋬ᧄ⎇ⓥ䈪䈲䋬ᱤ䈱༚ᄬ䈏⣖䈮ਈ䈋䉎ེ⾰⊛ᄌൻ䈱᦭ή䉕ᬌ⸛䈜䉎䈢䉄䈮䋬ήᱤ㗶⠪䈫᦭ᱤ㗶⠪䈱⣖ኈⓍ䈱㆑䈇䈮䈧䈇䈩Ყセ䉕ⴕ䈦䈢䋮䇭㸈䋮㩷ᣇᴺ䇭ⵍ㛎⠪䈲䋬㜞㦂⠪䈪ᱷሽᱤ20ᧄએ਄᦭䈜䉎ฝ೑䈐ஜᏱ㜞㦂᦭ᱤ㗶⠪⟲䋨᦭ᱤ㗶⠪⟲䋻↵ᕈ5ฬ䋬ᅚᕈ8ฬ䋬ᐔဋᐕ㦂81㪅8ᱦ䋺80㪄83ᱦ䋩㜞㦂⠪䈪ήᱤ㗶䈱ฝ೑䈐ஜᏱ㜞㦂ήᱤ㗶⠪⟲䋨ήᱤ㗶⠪⟲䋻↵ᕈ4ฬ䋬ᅚ
ᕈ7ฬ䋬ᐔဋᐕ㦂77㪅1ᱦ䋺71㪄82ᱦ䋩䉕ኻ⽎䈫䈚䈢䋮⣖
ኈⓍᄌൻ䈱ෂ㒾࿃ሶ䈫䈚䈩ోり∔ᖚ䋨㜞ⴊ࿶䋬♧ዩ∛䋬␹⚻∔ᖚ䋩䋬⹺⍮ᯏ⢻ᬌᩏ䋨MSSE䋩䈮㑐䈚䈩ᬌ⸛䉕 ⴕ 䈦 䈢 䋮 ᷹ ቯ 䈮 䈲 3㪅0㩷 TMR 䉴 䉨 䊞 䊅 䊷 䋨 Signa
EXCITE㩷HD㪃㩷GE䋩䉕↪䈇䈩T1㩷ᒝ⺞↹௝ᴺ䈮䈩᭴ㅧ↹௝䉕᠟௝䈚䈢䋮ᓧ䉌䉏䈢᭴ㅧ↹௝䈎䉌ో䈩䈱ⵍ㛎⠪䈮䈍䈇䈩⣖䈱ᆔ❗䋬10㩷mm䉕⿥䈋䉎ⴊ▤๟࿐⣧䈱᜛ᄢ䈏⹺䉄䉌䉏䈭䈇䈖䈫䉕⏕⹺䈚䈢䋮↹௝⸃ᨆ䈮䈲⣖ᯏ⢻↹௝⸃ᨆ䉸䊐䊃䋨SPM8䋩䉕૶↪䈚䋬ήᱤ㗶⠪䈫᦭ᱤ㗶⠪䈱⣖ኈⓍ䉕Ყセᬌ⸛䈜䉎䈢䉄䈮Voxel㩷Based
Morphometry䋨VBM䋩䈮䉋䉍⹏ଔ䈚䈢䋮䊗䉪䉶䊦Ფ䈮tᬌቯ䉕ⴕ䈇䋬ᓧ䉌䉏䈢㗔ၞ䈱MNI㩷ᐳᮡ䈲⸃೬ቇ⊛ᐳᮡ䈫㊀䈰ว䉒䈞䈩⣖ㇱ૏䉕หቯ䈚䈢䋮䇭䈭䈍䋬ᧄ⎇ⓥ䈲ጤᚻක⑼ᄢቇ୶ℂᆔຬળ䈱ᛚ⹺
䋨No㪅㩷01071䋩䉕ᓧ䈩ⴕ䈦䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ䇭᦭ᱤ㗶⠪⟲䈫ήᱤ㗶⠪⟲䈱⊕⾰䋨White㩷Matter䋩䈪䈲᦭ᗧ䈭ᄌൻ䈲⹺䉄䉌䉏䈭䈎䈦䈢䋨P㪓0㪅001䋩䋮䈚䈎䈚䋬Ἧ⊕⾰䋨Gray㩷Matter䋩䈮䈍䈇䈩䈲⸥ᙘ䉇ⓨ㑆ቇ⠌⢻ജ䈮㑐䉒䉎ᶏ㚍䋨Hippocampus䋩䋬ቇ⠌䈫⸥ᙘ䉲䉴䊁䊛䈮㑐ਈ䈚䈩䈇䉎የ⁁ᩭ䋨Caudate㩷Nuculeus䋩䋬⦡ᖱႎ䈱ಣℂ䉇⹺⍮ᯏ⢻䈮㑐ਈ䈚䈩䈇䉎䈫⠨䈋䉌䉏䈩䈇䉎⚜㍝⁁࿁䋨Fusiform㩷Gyrus䋩䈮䈍䈇䈩᦭ᗧ䈭Ꮕ䉕⹺䉄䈢䋨P㪓0㪅001䋩䋨࿑䋩䋮䇭એ਄䉋䉍䋬ᱤ䈱༚ᄬ䈲⸥ᙘ䊶ቇ⠌䊶⹺⍮䈮㑐ਈ䈜䉎⣖ㇱ૏䈱ኈⓍ䉕ૐਅ䈘䈞䉎น⢻ᕈ䈏䈅䉎䈖䈫䈏␜ໂ
䈘䉏䈢䋮
䇭
㸊䋮㩷ᢥ₂
1䋩 Ono Y, Yamamoto T, Kubo KY, Onozuka M.
Occlusion and brain function: mastication as aprevention of cognitive dysfunction. J Oral
Rehabil 2010; 37: 624-640.

ኈⓍ䈱ૐਅ䉕⹺䉄䈢⣖ㇱ૏䇭

─ 116 ─日補綴会誌

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8・125 回特別号，2016

課題口演発 表⺖㗴㪌ⷐᡰេ䊶ⷐ੺⼔㜞㦂⠪䈮䈍䈔䉎↢๮੍ᓟ䈍䉋䈶ૐ૕㊀⊒↢䈱䊥䉴䉪࿃ሶ䈱ᬌ⸛䂾ዊጊ⛗ℂ 㪈㪀䋬ᄢ㊁䇭ᓀ 㪉㪀䋬ጊᧄ㆏ઍ 㪊㪀䋬ਃ㊁ථ຦ 㪈㪀䋬㤥㦮㓁ሶ 㪈㪀䋬ਛᎹ᤯テ 㪈㪀䋬ㅩဈ䇭ථ 㪈㪀䋬ᴧᧄ䇭⾫ 㪈㪀䋬✽⒩ਭ⟤ሶ 㪈㪀䋬᳓ญ⌀ታ 㪈㪀䋬᳓ญ䇭৻ 㪈㪀䋬೨Ꮉ⾫ᴦ 㪈㪀䋬┄ᧁᜏ↵ 㪈㪀㪈㪀ጟጊᄢቇᄢቇ㒮කᱤ⮎ቇ✚ว⎇ⓥ⑼䉟䊮䊒䊤䊮䊃ౣ↢⵬✄ቇಽ㊁䋬㪉㪀ጟጊᄢቇ∛㒮ᣂක≮⎇ⓥ㐿⊒䉶䊮䉺䊷䋬 㪊㪀䈅䈇䈱㉿䉪䊥䊆䉾䉪ᱤ⑼
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A prospective cohort study on risk factors for mortality and underweight in the elderly with nursing care.
Koyama E 1), Kimura-ono A 2), Yamamoto M 3), Mino T 1), Kurosaki Y 1), Nakagawa S 1), Osaka S 1),
Numoto K 1), Nawachi K 1), Inoue-minakuchi M 1), Minakuchi H 1), Maekawa K 1), Kuboki T 1)
1)
Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutial Science, 2)Center of Innovative Clinical Medicine, Okayama
University Hosptal, 3)Dental Clinic, Ainosato㸇䋮㩷⋡⊛䇭ㄭᐕ䋬ⷐ੺⼔㜞㦂⠪䈱ᯏ⢻ૐਅ䉇↢๮੍ᓟ䈮㑐ㅪ䈜䉎䊥䉴䉪࿃ሶ䈱ត⚝䈏㊀ⷐ䈭⺖㗴䈫䈭䉍䋬ᕈ೎䋬ᐕ㦂䋬ၮᧄ⊛ᣣᏱ↢ᵴേ૞䋨ADL䋩䈮ട䈋䋬ૐ૕㊀䈏ᱫ੢䈱䊥䉴䉪࿃ሶ䈪䈅䉎䈖䈫䈏ႎ๔䈘䉏䈩䈇䉎䋮৻ᣇ䋬ஜᏱ䊶⯯ᒙ㜞㦂⠪䈮䈍䈇䈩䈲䋬ᱷሽᱤᢙ䊶ᯏ⢻ᱤᢙ䈱ᷫዋ䉇ຏวᡰᜬ䈱༚ᄬ䈫䈇䈦䈢ญ⣧ⷐ࿃䉅䋬ᱫ੢䉇
ૐ૕㊀䈱䊥䉴䉪࿃ሶ䈪䈅䉎䈖䈫䈏᣿䉌䈎䈮䈘䉏䈩䈇䉎䋮䈚䈎䈚ᧄ㇌䈮䈍䈇䈩䋬ⷐ੺⼔㜞㦂⠪䉕ኻ⽎䈮ญ⣧䈫ᱫ੢䋬ૐ૕㊀䈱㑐ㅪ䉕ᬌ⸛䈚䈢❑ᢿ⎇ⓥ䈲䈾䈫䉖䈬䈭䈇䋮䇭䈠䈖䈪䋬ᣉ⸳౉ᚲ䈍䉋䈶࿷ቛ≮㙃ਛ䈱ⷐ੺⼔㜞㦂⠪䉕ኻ⽎䈮䋬↢๮੍ᓟ䈍䉋䈶ૐ૕㊀⊒↢䈱䊥䉴䉪࿃ሶ䉕䋬ญ⣧ⷐ࿃䉕฽䉄䈩หቯ䈜䉎䈖䈫䉕⋡⊛䈮೨ะ䈐䉮䊖䊷䊃⎇ⓥ䉕ⴕ䈦䈢䋮䇭㸈䋮㩷ᣇᴺ䇭ኻ⽎䈲2013ᐕ7᦬䈮䋬ጟጊᏒౝ䈱䋬䈅䉎⠧ੱ଻ஜᣉ⸳䈮ㅢᚲ䉅䈚䈒䈲౉ᚲ䈚䈩䈇䉎ోⷐᡰេ䊶ⷐ੺⼔㜞㦂⠪䈫䈚䋬ᧄੱ䉅䈚䈒䈲ઍ⻌⠪䈮หᗧ䈏ᓧ䉌䉏䈭䈎䈦䈢䉅䈱䈲㒰ᄖ䈚䈢䋮⋡⊛ኻ⽎225ฬ㩿ᐔဋᐕ㦂䋺83㪅1
㫧9㪅5ᱦ䋬↵㪆ᅚ䋺63㪆162㩷 ฬ㪀䈱ญ⣧ౝ⸻ᩏ㩿ᱷሽᱤᢙ䋬ᯏ⢻ᱤᢙ㪀䈍䉋䈶੺⼔⸥㍳⺞ᩏ㩿BMI䋬㘩ᒻᘒ䋬⥃ᐥ⊛⹺⍮∝ዤᐲ䌛CDR䌝䋬Barthel㩷 Index䌛BI䌝䋬
Mini㩷 Nutritional㩷 Assessment㪄Short㩷 Form㪲MNA㪄SF㪴
1㪀䋩䉕ⴕ䈇䋬㩷1ᐕᓟ䈮ห᭽䈱ㅊ〔⺞ᩏ䉕ⴕ䈦䈢䋮䇭䉣䊮䊄䊘䉟䊮䊃䈲䋬ㅊ〔ᦼ㑆ਛ䈱ᱫ੢⊒↢䈍䉋䈶ᣂ䈢䈭ૐ૕㊀㩿BMI䋼18㪅5㪀䈱⊒↢䈫䈚䈢䋮1ᐕ㑆䈱⚥Ⓧ↢ሽ₸䈱▚಴䈮䈲䋬Kaplan㪄Meierᴺ䉕↪䈇䈢䋮ᱫ੢⊒↢䈮㑐䈜䉎䊥䉴䉪࿃ሶ䈱ᬌ⸛䈮䈲䋬COXᲧ଀䊊䉱䊷䊄ಽᨆ䉕ⴕ䈦䈢䋮ૐ૕㊀⊒↢䈱䊥䉴䉪࿃ሶ䈱ᬌ⸛䈮䈲䋬ᄙ㊀䊨䉳䉴䊁䉞䉾䉪࿁Ꮻಽᨆ䉕↪䈇䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ
䇭225ฬ䈱䈉䈤䋬䊔䊷䉴䊤䉟䊮ᤨ䈱⺞ᩏ␿䈏ឥ䈦䈢ታ㓙ኻ⽎䈲216ฬ㩿ᐔဋᐕ㦂䋺83㪅2㫧9㪅8ᱦ䋬↵㪆ᅚ䋺63㪆153
ฬ㪀䈪䈅䈦䈢䋮䈠䈚䈩䋬ㅊ〔⺞ᩏᤨ䈮หᗧ᠗࿁䈚䈢33

ฬ䉕㒰䈒183ฬ㩿ᐔဋᐕ㦂䋺84㪅1㫧9㪅7ᱦ䋬↵㪆ᅚ䋺55㪆
128ฬ㪀䉕⸃ᨆኻ⽎䈫䈚䈢䋮
䇭1ᐕ㑆䈪183ฬਛ㩷28ฬ䈏ᱫ੢䈚䋬⚥Ⓧ↢ሽ₸䈲84㪅
4䋦䈪䈅䈦䈢䋮⸃ᨆ䈱⚿ᨐ䋬㜞ᐕ㦂㩿䊊䉱䊷䊄Ყ䌛HR䌝䋺
1㪅1㪀䋬ૐ૕㊀㩿HR䋺2㪅6㪀䋬BI㩷40ὐᧂḩ㩷㩿HR䋺3㪅6㪀䈏䋬ᱫ੢䈱䊥䉴䉪࿃ሶ䈫䈚䈩หቯ䈘䉏䈢䋮䇭䊔䊷䉴䊤䉟䊮ᤨ䈮ૐ૕㊀䈪䈭䈎䈦䈢106ฬ䈱䊂䊷䉺䉕↪䈇䈩䋬ૐ૕㊀䈱䊥䉴䉪࿃ሶ䉕ᬌ⸛䈚䈢䋮1ᐕᓟᣂ䈢䈮ૐ૕㊀䈫䈭䈦䈢䈱䈲10ฬ䈪䋬㜞ᐕ㦂䋨䉥䉾䉵Ყ
䌛OR䌝䋺1㪅1䋩䋬ૐᯏ⢻ᱤᢙ䋨OR䋺1㪅1䋩䋬ૐᩕ㙃䋨OR䋺
15㪅9䋩䋬㘩੐䈱੺ഥ䉕ⷐ䈜䉎䈖䈫䋨OR䋺356㪅1䋩䈏䋬ૐ૕㊀⊒↢䈱䊥䉴䉪࿃ሶ䈫䈚䈩หቯ䈘䉏䈢䋮䇭䈖䉏䈮䉋䉍䋬ᯏ⢻ᱤᢙ䈏ᱫ੢䊥䉴䉪䈱೨Ბ㓏䈫⠨䈋䉌䉏䉎ૐ૕㊀䊥䉴䉪䈱৻䈧䈫⷗䈭䈘䉏䈢䋮䈜䈭䉒䈤䋬นㅒ⊛䈭ⷐᡰេ䊶ⷐ੺⼔⁁ᘒ䈮䈍䈇䈩䈲䋬ᯏ⢻ᱤᢙ䈱࿁ᓳ䈏ૐ૕㊀䉕ᡷༀ䈜䉎᦭ല䈭ᴦ≮䉥䊒䉲䊢䊮䈫䈭䉎น⢻ᕈ䈏⠨䈋䉌䉏䉎䋮੹ᓟ䈲䋬ᖚ⠪୘䇱䈱⁁ᴫ䈮ว䉒䈞䈢䋬ᯏ⢻ᱤᢙ䈱⛽ᜬ䊶ᡷༀ䉕⋡ᮡ䈫䈜䉎ㆬᛯ⊛⵬✄ᴦ≮䈱᦭ലᕈ䉕᣿䉌䈎䈮䈜䉎䈢䉄䋬೨ะ䈐੺౉⎇ⓥ䈏ᔅⷐ䈫⠨䈋䉎䋮䇭㸊䋮㩷ᢥ₂
1䋩 Kuzuya M. Kanda S. Koike T. Satake S. Iguchi
A. Evaluation of Mini-Nutritional Assessment
for Japanese frail elderly. Nutrition 2005䋻21䋺
498-503.
⴫䇭ૐ૕㊀⊒↢䈱䊥䉴䉪࿃ሶ䈱ᬌ⸛䋨ᄙᄌ㊂⸃ᨆ䋩䇭

─ 117 ─

第 1 日 第 2 会場

日補綴会誌

8・125 回特別号，2016

課題 口 演 発 表⺖㗴㪍ᩮ▤⽎‎⾰ធ⌕䈮䈍䈔䉎䊥䊮㉄䋬ᰴ੝Ⴎ⚛㉄Ⴎ䈫䉴䊦䊐䉞䊮㉄Ⴎಣℂ䈱ലᨐ
䂾ਛ⼱ᣧᏗ 㪈㪀䋬ፃ䇭◊ผ 㪈㪀䋬ო⼱⍮⨃ 㪈㪀䋬Ꮉญ᣿ᣣ㚅 㪈㪀䋬↰ዥ⵨ሶ 㪈㪀䋬ਃᶆᴦ㇢ 㪉㪀䋬᧻ᧄ⌀ℂሶ 㪊㪀䋬⍫⼱ඳᢥ 㪈㪀㪈㪀ᄢ㒋ᄢቇᄢቇ㒮ᱤቇ⎇ⓥ⑼䉪䊤䉡䊮䊑䊥䉾䉳⵬✄ቇಽ㊁䋬 㪉㪀ᄢ㒋ᄢቇᄢቇ㒮ᱤቇ⎇ⓥ⑼✚ว⸻≮ㇱ䋬 㪊㪀ർᶏ㆏ᄢቇᄢቇ㒮ᱤቇ⎇ⓥ⑼ᱤ⑼଻ሽቇᢎቶ

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Effectiveness of phosporic acid,sodium hypochlorite and sulfinic acid sodium salt treatment on root dentinresin bonding
Nakatani H 1), Mine A 1), Kabetani T 1), Kawaguchi A 1), Tagiri Y 1), Miura J 2), Matsumoto M 3), Yatani H 1)
1)
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, 2)General medical
treatment part, Osaka University Graduate School of Dentistry, 3)Department of Restorative Dentistry,
Hokkaido University Graduate School of Dental Medicine㸇䋮㩷⋡⊛䇭ᡰบ▽ㅧ䈮䈍䈇䈩䋬ᩮ▤䊘䉴䊃ሹ⽎‎⾰䈫䊧䉳䊮䈱ធ⌕䈲᭽䇱䈭ⷐ࿃䈎䉌࿎㔍䈪䈅䉎䈖䈫䈏⍮䉌䉏䈩䈇䉎1㪀䋮ᧄ⎇ⓥ䈪䈲䋬ᩮ▤䊘䉴䊃ሹ⽎‎⾰䈫䉮䊮䊘䉳䉾䊃䊧䉳䊮䈱ធ⌕⢻䈱ะ਄䉕⋡⊛䈫䈚䈩ធ⌕㒖ኂ࿃ሶ䈫⠨䈋䉌䉏䉎䊘䉴䊃ሹᒻᚑᓟ䈱ෘ䈇䉴䊜䉝䊷ጀ䉕㒰෰䈜䉎䈢䉄䈱䊥䊮㉄ಣℂ䋬䈠䉏䈮䉋䈦䈩↢䈛䉎䉮䊤䊷䉭䊮✢⛽ጀ䉕㒰෰䈜䉎䈢䉄䈱ᰴ੝Ⴎ⚛㉄䊅䊃䊥䉡䊛ಣℂ䈍䉋
䈶ㆶర೷䈪䈅䉎䉴䊦䊐䉞䊮㉄䊅䊃䊥䉡䊛ಣℂ䈱ലᨐ䉕ᄙ㕙⊛䈮ᬌ⸛䈚䈢䋮䇭㸈䋮㩷ᣇᴺ1䋮ᩮ▤⽎‎⾰䈮ኻ䈜䉎ೋᦼធ⌕⢻⹏ଔ䇭䈉ⲁ䈮⟜ᖚ䈚䈩䈇䈭䈇ᣂ㞲䊍䊃නᩮ▤ᛮ෰ᱤ36ᧄ䉕ᩮ▤లႯᓟ䋬ᩮ▤ᒻᚑ䊋䊷䈪䊘䉴䊃䈱㐳䈘䉕䉶䊜䊮䊃䉣䊅䊜䊦Ⴚ䉋䉍10㩷mm䈮⛔৻䈚䈩ᩮ▤ᒻᚑ䉕ⴕ䈦䈢䋮⹜ᢱ䉕ή૞ὑ䈮3䉫䊦䊷䊒䈮ಽ䈔䋬శ㊀วဳ䉝䊄䊍䊷䉲䊑䊧䉳䊮䈫ᡰบ▽ㅧ↪䉮䊮䊘䉳䉾䊃䊧䉳䊮䋨䉪䊥䉝䊐䉞䊦䊗䊮䊄㩷SE㩷ONE䈫DC䉮䉝䉥䊷䊃䊚䉾䉪䉴䋬䉪䊤䊧䊉䊥䉺䉬䊂䊮䉺䊦䋩䉕↪䈇䋬ᬺ⠪ᜰ␜䈮ᓥ䈦䈩ᡰบ▽ㅧ䉕ⴕ䈦䈢⟲䉕ኻᾖ⟲䋬䊘䉴䊃ሹ๟࿐䈱⽎‎⾰䉕䊥䊮㉄䋨K㪄䉣䉾䉼䊞䊮䊃䉭䊦䋬䉪䊤䊧䊉䊥䉺䉬䊂䊮䉺䊦䋩ಣℂ䈮
⛯䈇䈩ᰴ੝Ⴎ⚛㉄䊅䊃䊥䉡䊛䋨AD䉭䊦䋬䉪䊤䊧䊉䊥䉺䉬䊂䊮䉺䊦䋩䈪ಣℂ䈚䈢ᓟ䋬ኻᾖ⟲䈫ห᭽䈮ᡰบ▽ㅧ䉕ⴕ䈦䈢⟲䉕NCಣℂ⟲䋬NCಣℂ⟲䈫ห᭽䈱ಣℂ䉕ⴕ䈦䈢ᓟ㪃䉴䊦䊐䉞䊮㉄䊅䊃䊥䉡䊛䋨䉝䉪䉶䊦䋬䉰䊮䊜䊂䉞䉦䊦䋩䈮䈩ಣℂ䈚㪃ኻᾖ⟲䈫ห᭽䈮ᡰบ▽ㅧ䉕ⴕ䈦䈢⟲
䉕NC㪂AC⟲䈫䈚䈢䋮䇭૞⵾䈚䈢⹜ᢱ䋨ฦ⟲3ᱤ䋩䉕ᱤゲ䈮ᐔⴕ䈮ಾᢿ䈚㪃⿛ᩏ㔚ሶ㗼ᓸ㏜䋨એਅSEM䋩䈮䈩ᩮ▤⽎‎⾰䋭䊧䉳䊮⇇㕙䈱ⷰኤ䉕ⴕ䈦䈢䋮䇭ᡰบ▽ㅧ䉕ⴕ䈦䈢⹜ᢱ䋨ฦ⟲9ᱤ䋩䉕37㩷㷄᳓ਛ䈮24ᤨ㑆ᶐẃ䈚䈢ᓟ䋬ᱤ౰஥䉋䉍1㩷mm䈱ෘ䉂䈪ᱤゲ䈮⋥੤䈜䉎䉋䈉䈮⹜ᢱ䉕6ᨎಾ䉍಴䈚䈢䋮䈘䉌䈮䋬ฦ⹜ᢱ䈎
䉌1㩷mm㩷㬍㩷1㩷mm䈱䊎䊷䊛⁁⹜ᢱ䉕1ᧄ૞⵾䈚䋬ዊဳථ਄⹜㛎ᯏ䈮䈩ᓸዊᒁᒛធ⌕⹜㛎䉕ⴕ䈦䈢䋮⚿ᨐ䈲ੑర㈩⟎ಽᢔಽᨆ䈍䉋䈶ᄙ㊀Ყセᬌቯ䉕ⴕ䈇䋬᦭ᗧ᳓Ḱ䈲5㩷㩼䈫䈚䈢䋮─ 118 ─2䋮⴫㕙ర⚛ಽᨆ䈫㊀วᐲ⹏ଔ䇭䊍䊃ᛮ෰ᄢ⥓ᱤ䉕ᱤ౰䈱ᦨᄢ⼾㓉ㇱ䈪ᱤゲ䈮ኻ䈚䈩ု⋥䈮ಾᢿ䈚䋬⠴᳓䊕䊷䊌䊷⎇⏴䈚䈢⽎‎⾰ᐔṖ㕙⹜ᢱ䉕૞⵾䈚䋬ฦ⴫㕙ಣℂᓟ䈮X✢శ㔚ሶಽశᴺ
䋨XPS䋩䉕↪䈇䈩⴫㕙䈱ర⚛ಽᨆ䉕ⴕ䈦䈢䋮䇭䉁䈢䋬XPSర⚛ಽᨆ䈫ห᭽䈱ᚻᴺ䈪䋬⽎‎⾰ᐔṖ㕙⹜ᢱ䉕૞⵾䈚䋬䊧䊷䉱䊷䊤䊙䊮ಽశᴺ䈮䉋䉍ᱤゲ䈫ᐔⴕ䈮ಾᢿ䈚䈢৻ᣇ䈱⹜ᢱ䈱㊀วᐲ䉕⧐㚅ᣖC㪔C䈫⢽⢌ᣖC㪔C䈱䊏䊷䉪䈱Ყ䉕䈫䉎䈖䈫䈪⹏ଔ䈚䋬䉅䈉৻ᣇ䈱
⹜ᢱ䈲SEM䈮䉋䉎ᒻᘒⷰኤ䉕ⴕ䈦䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ
1䋮ᩮ▤䊘䉴䊃ሹ⽎‎⾰䈮ኻ䈜䉎ೋᦼធ⌕⢻⹏ଔ
䇭SEMⷰኤ䈱⚿ᨐ䋬NCಣℂ⟲䈍䉋䈶NC㪂ACಣℂ⟲䈪䈲⽎‎⚦▤ౝ䈮䊧䉳䊮䉺䉫䈏ᒻᚑ䈘䉏䈩䈇䈢䈏䋬ኻᾖ⟲䈪䈲ᒻᚑ䈘䉏䈩䈇䈭䈎䈦䈢䋮
䇭㱘TBS⹜㛎䈱⚿ᨐ䋬NC㪂ACಣℂ⟲䈲ઁ䈱2⟲䈫Ყセ䈚䈩᦭ᗧ䈮㜞䈇ធ⌕ᒝ䈘䉕␜䈚䈢䋨vs㪅ኻᾖ⟲㪑㩷P㩷㪔
0㪅001㪃㩷vs㪅NC⟲㪑㩷P㩷㪔㩷0㪅004䋩䋮
2䋮⴫㕙ర⚛ಽᨆ䈫㊀วᐲ⹏ଔ䇭XPS䈮䉋䉎⴫㕙䈱ర⚛ಽᨆ䈮䉋䉍䋬ᰴ੝Ⴎ⚛㉄䊅䊃䊥䉡䊛ಣℂ䉕ⴕ䈉䈫䋬᳓ᵞᓟ䉅⴫㕙䈮Cl䉇Na䈏ᱷሽ䈜䉎䈖䈫䈏⏕⹺䈘䉏䈢䋮䊤䊙䊮ಽᨆ䈱⚿ᨐ䋬ᰴ੝Ⴎ⚛㉄䊅䊃䊥䉡䊛ಣℂᓟ䈲㊀ว䈏㒖ኂ䈘䉏䈩䈍䉍䋬䈠䈱ᓟ䈮䉴䊦䊐䉞䊮㉄䊅䊃䊥䉡䊛ಣℂ䉕ⴕ䈉䈖䈫䈪䋬㊀วᐲ䈏࿁ᓳ䈜䉎䈖䈫䈏⏕⹺䈘䉏䈢䋮䇭એ਄䉋䉍䋬䊥䊮㉄ಣℂ䋬ᰴ੝Ⴎ⚛㉄䊅䊃䊥䉡䊛ಣℂ䈮
⛯䈇䈩䉴䊦䊐䉞䊮㉄䊅䊃䊥䉡䊛ಣℂ䉕ㅊട䈜䉎䈖䈫䈪䋬䊧䉳䊮䈫ᩮ▤⽎‎⾰䈫䈱⦟ᅢ䈭ធ⌕䈏㆐ᚑ䈘䉏䉎䈖䈫䈏᣿䉌䈎䈫䈭䈦䈢䋮䇭㸊䋮㩷ᢥ₂
1䋩 Matsumoto M䋬Miura J䋬Takeshige F䋬Yatani H䋮
Mechanical and morphological evaluation of thebond-dentin interface in direct resin core buildup method. Dent Mater䋮2013䋻 29䋺 287-93.

日補綴会誌

第 1 日 第 2 会場

8・125 回特別号，2016

課題口演発 表⺖㗴㪎⢽⢌⚵❱↱᧪ᐙ⚦⢩䈮䉋䉎⮎೷㑐ㅪᛮᱤ┃ᴦ≹ਇో䈻䈱⎬エ⚵❱ᴦ≹ଦㅴലᨐ䇭䂾㤥᎑િ৻㇢ 㪈㪃㪉㪀䋬૒䇱ᧁቬノ 㪈㪀䋬ਛፉ๺ᘮ 㪈㪀䋬㕍ᧁ䊡䊥 㪈㪀䋬Ỉἑ䇭㓉 㪈㪀
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㐳ፒᄢቇᄢቇ㒮කᱤ⮎ቇ✚ว⎇ⓥ⑼ญ⣧䉟䊮䊒䊤䊮䊃ቇಽ㊁䋬㪉㪀㐳ፒᄢቇ∛㒮ญ⣧䊶㗶䊶㗻㕙䉟䊮䊒䊤䊮䊃䉶䊮䉺䊷䇭䇭

Implantation of adipose-derived regenerative cells promotes soft and hard tissue healing in impaired tooth
extraction healing in mice
Kuroshima S 1,2), Sasaki M 1), Nakajima K 1), Aoki Y 1), Sawase T 1)
1)
Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagaski University, 2)
Oral and Maxillofacial Implant Center, Nagasaki University Hospital㸇䋮㩷⋡⊛䇭⮎೷㑐ㅪ㗶㛽უᱫ䋨MRONJ䋩䈲ਥ䈫䈚䈩䊎䉴䊐䉤䉴䊐䉤䊈䊷䊃䋨BP䋩⵾೷䉇᛫RANKL᛫૕૶↪ᖚ⠪䈻䈱ᛮᱤᓟ䈮⊒∝䈜䉎䈏䋬⟵ᱤ䉇䉟䊮䊒䊤䊮䊃ᴦ≮䈪⿠䈖䉎႐ว䉅䈅䉍䋬ᖚ⠪䈱ญ⣧㑐ㅪQOL䈲⪺䈚䈒ૐਅ䈜
䉎䋮MRONJ䈲఺∉ᯏ᭴䈱⎕✋䈫䈱㑐ㅪᕈ䈏␜ໂ䈘䉏
䈩䈇䉎1䋩䈏䋬᳿ቯ⊛䈭∛࿃䈲ਇ᣿䈪⏕ቯ⊛䈭ᴦ≮ᴺ䈲ሽ࿷䈚䈭䈇䋮
䇭৻ᣇ䋬ᐙ⚦⢩ᴦ≮䈲ౣ↢ක≮⎇ⓥ䈱ਥゲ䈱䈵䈫䈧䈪䈅䉎䈏䋬ታ↪ൻ䈻ะ䈔ૐଚⷅ䈪቟ోᕈ䈱㜞䈇⚦⢩Ḯ䈱⏕଻䈏ᦸ䉁䉏䈩䈇䉎䋮ㄭᐕ䈪䈲䋬Ყセ⊛◲ଢ䈮ណข䈪䈐䉎⢽⢌⚵❱↱᧪ᐙ⚦⢩䋨Adipose㪄derived
regenerative㩷cells䋺ADRC䋩䈏ᵈ⋡䈘䉏䋬ක⑼㗔ၞ䈪䈲ᣢ䈮ᄙᣇ㕙䈪⥃ᐥ⎇ⓥ䈏ⴕ䉒䉏䈩䈇䉎䋮䈠䈖䈪ᚒ䇱
䈲ADRC䈱Ἳ∝ᡷༀലᨐ䈮⌕⋡䈚䋬ADRC䈱⚦⢩ᴦ≮䈲MRONJ䉕ᴦ≹䈘䈞䉎䈫઒⺑䉕┙䈩䈢䋮ᧄ⎇ⓥ䈱
⋡⊛䈲䋬᛫≸೷䈫BP⵾೷䈱૬↪䈏䉅䈢䉌䈜ᛮᱤ┃ᴦ≹ਇో䈮ኻ䈚䈩䋬ADRC䉕↪䈇䈢⚦⢩≮ᴺ䈏ਈ䈋䉎ᓇ㗀䉕ᬌ⚝䈜䉎䈖䈫䈮䈅䉎䋮䇭㸈䋮㩷ᣇᴺ1䋮ᛮᱤ┃ᴦ≹ਇో䊝䊂䊦䈱૞⵾
䇭C57BL㪆6J䊙䉡䉴䉕↪䈇䈢䋨േ‛ታ㛎ᆔຬળᛚ⹺⇟ภ1306141071㪄2䋩䋮⮎೷ᛩਈᦼ㑆䈲7ㅳ㑆䈪䋬ᛩਈ㐿ᆎ3ㅳ㑆ᓟ䈮ਔ஥╙1ᄢ⥓ᱤ䉕ᛮᱤ䈚䈢䋮⮎೷ᛩਈ
䈲䋬↢ℂ㘩Ⴎ᳓䋨VC䋩ᛩਈ⟲䋬BP⵾೷䋨ZA䋩ᛩਈ⟲䋬᛫≸೷䋨䉲䉪䊨䊖䉴䊐䉜䊚䊄䋺CY䋩ᛩਈ⟲䋬CY䋫ZA⟲
䈱4⟲䈪䋬ᛮᱤ┃ᴦ≹⁁ᘒ䉕ᬌ⚝䈚䈢䋨ฦ⟲n㪔10䋩䋮
2䋮ADRC䈱ᛮᱤ┃䈻䈱ᓇ㗀䇭CY䈫ZA䉕3ㅳ㑆ᛩਈᓟ䈮ਔ஥╙1ᄢ⥓ᱤ䈱ᛮᱤ䈫
ADRC⒖ᬀ䋨የ㕒⣂䋩䉕ⴕ䈇䋬ADRC⒖ᬀᓟ1ᣣ⋡䈫14ᣣ⋡䈪ᛮᱤ┃䈱ᴦ≹䉕ᬌ⚝䈚䈢䋮ኻᾖ⟲䈮䈲↢ℂ㘩
Ⴎ᳓䉕ᛩਈ䈚䈢䋨ฦ⟲n㪔8䋩䋮ADRC䈲ㅢᴺ䈮ᓥ䈇㥘ᓘㇱ⢽⢌⚵❱䈎䉌ណข䈚䈩㕖ၭ㙃䈪૶↪䈚䈢2䋩䋮䈘䉌䈮䋬↢⚦⢩䉕ᨴ⦡䈜䉎⹜⮎䈪䈅䉎PKH26䈪ಣℂ䈚䈢
ADRC䈱⒖ᬀ䉅ᛮᱤᓟ䈮ⴕ䈦䈢䋨n㪔5䋩䋮
3䋮ฦ⒳⸃ᨆ䈫⛔⸘ಣℂ䇭ዼᲕ䈚䈢ో䊙䉡䉴䈎䉌ណข䈚䈢਄㗶㛽䈫㐳▤㛽䉕↪
䈇䋬䊙䉟䉪䊨CT䈮䉋䉎3ᰴర⊛᭴ㅧ⸃ᨆ䈫䋬⚵❱ಾ䈱䊓䊙䊃䉨䉲䊥䊮䊶䉣䉥䉳䊮ᨴ⦡䋬TRAPᨴ⦡䋬䊃䊤䉟䉪䊨䊷䊛ᨴ⦡䋬ฦ⒳఺∉ᨴ⦡䈮䉋䉎⚵❱⸃ᨆ䉕ⴕ䈦䈢䋮ዼᲕᤨ䈮ណข䈚䈢㛽㜑⚦⢩䈮䉋䉎ቯ㊂PCR䈪ฦ⒳ㆮવሶ⸃ᨆ䉅ⴕ䈦䈢䋮⛔⸘䈮䈲ฦ⒳tᬌቯ䋬ಽᢔಽᨆ䈫䊁䊠䊷䉨䊷䈱ᄙ㊀Ყセᬌቯ䉕↪䈇䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ䇭ᛮᱤᓟ4ㅳ䈪䈲䋬VC⟲䋬ZA⟲䋬CY⟲䈲ᴦ≹ਇో䉕䈾䈫䉖䈬⿠䈖䈘䈭䈎䈦䈢䈏䋬CY䋫ZA⟲䈲100䋦䈪ഃㇱ䈏㐿᡼䈚䋬ᛮᱤ┃䈲ᄢ㊂䈱უᱫ㛽䈫䉒䈝䈎䈭ᣂ↢㛽䈮ട䈋䋬Ἳ∝ᕈ⚦⢩䈱⪺᣿䈭ᶐẢ䈫䉮䊤䊷䉭䊮䈱᦭ᗧ䈭↥↢ૐਅ䉕⹺䉄䈢䋮એ਄䈎䉌䋬ᧄ⎇ⓥ䈪૶↪
䈚䈢᛫≸೷䈫BP⵾೷䈱૬↪䈲䋬ో䈩䈱ᛮᱤ┃䉕
MRONJ᭽䈱∛ᘒ䈮䈜䉎䈖䈫䈏⸽᣿䈘䉏䈢䋮䇭ᰴ䈮䋬૞⵾䈚䈢ᛮᱤ┃ᴦ≹ਇో䊝䊂䊦䈮ADRC䉕
⒖ᬀ䈚䋬14ᣣ⋡䈱ᛮᱤ┃䉕ᬌ⚝䈚䈢䋮䈠䈱⚿ᨐ䋬
ADRC⒖ᬀ䈲ᛮᱤ┃ᴦ≹䉕᦭ᗧ䈮ଦㅴ䈚䈩䈇䈢䋮䈜
䈭䉒䈤ADRC⒖ᬀ⟲䈱ഃㇱエ⚵❱䈪䈲䋬᦭ᗧ䈭䉮䊤䊷䉭䊮䈱↥↢Ⴧട䈫Ἳ∝ᕈ⚦⢩ᶐẢ䈱ᷫዋ䈮ട䈋䋬⣂▤䈫䊙䉪䊨䊐䉜䊷䉳䈱᦭ᗧ䈭Ⴧട䉕⹺䉄䈢䋮৻ᣇ䋬ADRC⒖ᬀ⟲䈱ᛮᱤㇱ⎬⚵❱䈪䈲⎕㛽⚦⢩䈏᦭ᗧ䈮Ⴧട䈚䋬᦭ᗧ䈭უᱫ㛽䈱ᷫዋ䈫ᣂ↢㛽䈱Ⴧട䉕⹺䉄䈢䋮⥝๧ᷓ䈇䈖䈫䈮ADRC䈱⒖ᬀ䈲䋬ᛮᱤ┃ᴦ≹ਇో䈪․ᓽ⊛䈮⹺䉄䉌䉏䉎エ⚵❱ౝ䈱ᄢ㊂䈭
TRAP㓁ᕈනᩭ⚦⢩䈫ㆆ㔌⎕㛽⚦⢩䉕᦭ᗧ䈮ᷫዋ䈘䈞䋬㐳▤㛽䈮䈍䈇䈩䉅⚵❱⊛䈍䉋䈶ㆮવሶ⊛䈮ห᭽䈱⚿ᨐ䈏␜䈘䉏䈢䋮䈘䉌䈮ADRC⒖ᬀᓟ1ᣣ⋡䈫3ᣣ⋡䈪䈲䋬㛽㜑䈮䈍䈔䉎ᐙ⚦⢩䊙䊷䉦䊷䈏᦭ᗧ䈮਄᣹䈚䋬ഃㇱエ⚵❱䈪䈲⒖ᬀ3ᣣ⋡䈪PKH26㓁ᕈADRC䈏⹺䉄䉌䉏䈢䈖䈫䈎䉌䋬⒖ᬀ䈘䉏䈢ADRC䈲ోり䈻ㆆ⿛ᓟ䋬ADRC⥄り䈏ᵴᕈൻ䈜䉎䈎䋬䊌䊤䉪䊤䉟䊮⊛䈮ౝ࿷ᕈ䈱ᐙ⚦⢩䈏⾮ᵴൻ䈘䉏䋬⎬エ⚵❱䈱ᴦ≹ଦㅴലᨐ䈏⿠䈖䈦䈢น⢻ᕈ䈏⠨䈋䉌䉏䈢䋮䇭એ਄䈎䉌ADRC䈲䋬ᛩਈᣇᴺ䉕ᬌ⸛䈜䉏䈳MRONJ䈱ᴦ≮ᴺ㐿⊒䈮ᄢ䈐䈒ነਈ䈪䈐䉎䈖䈫䈏ಽ䈎䈦䈢䋮䇭㸊䋮㩷ᢥ₂
1䋩 Kuroshima S, Yamashita J. Chemotherapeuticandantiresorptive
combination
therapysuppressed lymphangiogenesis and induced
osteonecrosis of the jaw-like lesion in mice.
Bone 2013; 56:101-109.
2䋩 Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW,
Katz AJ et al. Multilineage cells from humanadipose tissue: implications for cell-based
therapies. Tissue Eng 2001; 7:211-228.

─ 119 ─

第 1 日 第 2 会場

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課題 口 演 発 表⺖㗴㪏ญ⣧☼⤑਄⊹䈮䈍䈔䉎ⷺൻ࿃ሶ䈱ត⚝䂾ᬀ↰ᷕੑ 㪈㪀䋬ᄢ㊁లᤘ 㪉㪀䋬ዊ⋓ᄢᔒ 㪈㪀䋬ศጟ⵨਽ 㪈㪀䋬࿦ጊ䇭ਗ਼ 㪈㪀䋬೨Ꮉ⾫ᴦ 㪈㪀䋬┄ᧁᜏ↵ 㪈㪀

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ጟጊᄢቇᄢቇ㒮කᱤ⮎ቇ✚ว⎇ⓥ⑼䉟䊮䊒䊤䊮䊃ౣ↢⵬✄ቇಽ㊁䋬㪉㪀ጟጊᄢቇᄢቇ㒮කᱤ⮎ቇ✚ว⎇ⓥ⑼ಽሶක⑼ቇಽ㊁䇭䇭

Identification of keratinaized mucosa-asociated gene
Ueda J 1), Ono M 2), Komori T 1), Yoshioka Y 1), Sonoyama W 1), Maekawa K 1), Kuboki T 1)
1)
Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of
Medicine, Dentistry and Pharmaceutical Sciences, 2)Molecular Biology and Biochemistry, Okayama
University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences㸇䋮㩷⋡⊛䇭ஜో䈭ᱤ䈱๟࿐䈮䈲䋬☼⤑਄⊹䈏ⷺൻ䈚䈢ⷺൻᱤ⡺䈫㕖ⷺൻ⚵❱䈪䈅䉎ᱤᮏ☼⤑䈏ሽ࿷䈜䉎䈏䋬䈭䈎䈪䉅ⷺൻᱤ⡺䈲ᱤ๟⚵❱䉕቞䉍䋬㐳ᦼ⊛䈮቟ቯ䈚䈢⁁ᘒ䉕⛽ᜬ䈜䉎䈢䉄䈮ᔅⷐਇนᰳ䈫⠨䈋䉌䉏䈩䈇䉎䋮ᱤ๟∛╬䈪ⷺൻᱤ⡺䉕ᄬ䈇䋬ㄝ✼ᱤ⡺䈏ᱤᮏ☼⤑䈱䉂䈫䈭䈦䈢႐ว䋬ⷺൻᱤ⡺䈱ౣ₪ᓧ䈮䈲䋬⃻࿷䈱䈫䈖䉐ㆆ㔌ᱤ⡺ᑯ⒖ᬀ䈭䈬䈱ᄖ⑼⊛ᚻᴺ䈏໑৻䈱ᣇᴺ䈪䈅䉎䋮䈚䈎䈚䋬ᱤᮏ☼⤑䉕ⷺൻᱤ⡺䈮⚵❱⺃ዉ䈪䈐䉏䈳䋬䉋䉍ૐଚⷅ䈭ⷺൻᱤ⡺䈱ౣ₪ᓧ䈏น⢻䈫䈭䉎䈎䉅䈚䉏䈭䈇䋮䈠䈱䉋䈉䈭⥃ᐥᚻᛛ䈱ታ⃻䈮䈲䋬ญ⣧☼⤑਄⊹䉕ⷺൻ⺃ዉ䈜䉎↢‛ቇ⊛࿃ሶ䈱⸃᣿䈏ਇนᰳ䈪䈅䉎䋮䈠䈖䈪ᧄ⎇ⓥ䈪䈲䋬ญ⣧☼⤑਄⊹䈱ⷺൻ䈮㑐ਈ䈜䉎࿃ሶ䈱หቯ䉕⋡⊛䈮䋬એਅ䈱ታ㛎䉕ታᣉ䈚䈢䋮
䇭㸈䋮㩷ᣇᴺ䇭䊤䉾䊃ญ⣧☼⤑䈎䉌ⷺൻᱤ⡺䈍䉋䈶ᱤᮏ☼⤑⚵❱䉕೎䇱䈮ណข䈚䈢䋮ⷺൻ䈱䊙䊷䉦䊷䈪䈅䉎Keratin㩷 1
㩿K1㪀㩷䈍䉋䈶Keratin㩷10㩷㩿K10㪀㩷䈱఺∉⚵❱ൻቇᨴ⦡෸
䈶ቯ㊂ᕈRT㪄PCRᴺ䈮䈩䈠䉏䈡䉏䈱⚵❱䈏․⇣⊛䈮ណข䈪䈐䈩䈇䉎䈖䈫䉕⏕⹺䈚䈢ᓟ䋬䈖䉏䉌䈱䉰䊮䊒䊦䉕↪䈇䈩cDNA㩷Microarray⸃ᨆ䉕ⴕ䈦䈢䋮᛽಴䈘䉏䈢࿃ሶ䈱ᯏ⢻⸃ᨆ䉕ⴕ䈉䈢䉄䋬Thin㩷Cert⚦⢩ၭ㙃䉟䊮䉰䊷䊃਄䈪䊍䊃ญ⣧ᚳᐔ਄⊹≸⚦⢩䈪䈅䉎TR146䉕䋬᛽಴䈘䉏䈢࿃ሶ䈱䊥䉮䊮䊎䊅䊮䊃䉺䊮䊌䉪⾰䉕฽䉃ၭ࿾ਛ䈪ၭ㙃䈚䋬਄⊹⚦⢩䈱ⷺൻ䈮ਈ䈋䉎ᓇ㗀䉕ᬌ⸛䈚䈢䋮䉁䈢䋬䊤䉾䊃ⷺൻᱤ⡺䉅䈚䈒䈲ᱤᮏ☼⤑䈱⚿ว⚵❱䈎䉌ណข䈚䈢✢⛽⧘⚦⢩䈫TR146䉕౒ၭ㙃䈚䋬⚿ว⚵❱䈱⋧㆑䈏਄⊹⚦⢩䈱ⷺൻ䈮ਈ䈋䉎ᓇ㗀䉕ᬌ⸛䈚䈢䋮䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ
䇭cDNA㩷Microarray⸃ᨆ䈱⚿ᨐ䋬䊤䉾䊃ญ⣧☼⤑䈱ⷺൻᱤ⡺䈫ᱤᮏ☼⤑䈲⋧ૃ䈚䈢ㆮવሶ䊒䊨䊐䉜䉟䊦䉕ᜬ䈦䈢⚵❱䈪䈅䈦䈢䋮䉁䈢䋬਄⊹⚦⢩䈱ⷺൻ䈮䈍䈇䈩ၮᐩ⤑䈏㊀ⷐ䈭ᓎഀ䉕ᨐ䈢䈜䈖䈫䈏⍮䉌䉏䈩䈇䉎1㪀䈖䈫䈮⌕⋡䈚䋬ⷺൻᱤ⡺䈮䈍䈇䈩3୚એ਄⊒⃻䈚䈩䈇䉎ㆮવሶ⟲䈱ਛ䈪䋬ၮᐩ⤑䈱᭴ᚑಽሶ䈪䈅䉎⚦⢩ᄖ䊙䊃䊥䉾䉪䉴㑐ㅪㆮવሶ䉕᛽಴䈚䈢䋮䈠䈱⚿ᨐ䋬ⷺൻᱤ⡺䈲ᱤᮏ☼⤑⚵❱䈫Ყセ䈚䋬ၮᐩ⤑᭴ᚑಽሶ䈪䈅䉎
Laminin㩷 㩿Lam㪀㩷 332䈱䉰䊑䊡䊆䉾䊃䈪䈅䉎Lam㱍3䋬
Lam㱎3䋬Lam㱏2䈱ㆮવሶ⊒⃻㊂䈏䈠䉏䈡䉏3㪅8୚䋬

3㪅0୚䋬3㪅0୚䈪䈅䈦䈢䋮䉁䈢䋬఺∉⚵❱ൻቇᨴ⦡䈮䈩Lam㱍3䈏ⷺൻᱤ⡺䈮䈍䈇䈩㜞⊒⃻䈚䈩䈇䉎䈖䈫䉕⏕⹺䈚䈢䋮ᰴ䈮䋬Lam332䈏਄⊹⚦⢩䈱ⷺൻ䈮ਈ䈋䉎ᓇ㗀䉕ᬌ⸛䈜䉎䈢䉄䋬TR146䉕䊍䊃䊥䉮䊮䊎䊅䊮䊃䉺䊮䊌䉪⾰ 䈪 䈅 䉎 rhLAM332 䈮 䈩 ೝ ỗ 䈚 䈢 䋮 䈠 䈱 ⚿ ᨐ 䋬
rhLAM332䈱Ớᐲ䈮ଐሽ䈚䈩䋬K1䋬K10䈱ㆮવሶ䈭䉌䈶䈮䉺䊮䊌䉪⾰䈱⊒⃻㊂䈲਄᣹䈚䈢䋨࿑䋩䋮䈘䉌䈮䋬ၮᐩ⤑䈲਄⊹䈫⚿ว⚵❱䈱㑆䈮ᒻᚑ䈘䉏䉎䈖䈫䈎䉌䋬ⷺൻᱤ⡺䈫ᱤᮏ☼⤑䈱ၮᐩ⤑䈱Lam332⊒⃻䈱⋧㆑䈲䋬⚿ว⚵❱䈱⋧㆑䈮↱᧪䈜䉎䈫䈇䈉઒⺑䈱䉅䈫䋬ⷺൻᱤ⡺↱᧪✢⛽⧘⚦⢩䈏ᱤ⡺䈱ⷺൻ䈮ਈ䈋䉎ᓇ㗀䉕ᬌ⸛䈚䈢䋮䈠䈱⚿ᨐ䋬ⷺൻᱤ⡺↱᧪✢⛽⧘⚦⢩䈫
TR146䉕౒ၭ㙃䈚䈢⟲䈮䈍䈇䈩䋬Lam㱍3䋬Lam㱏2䈱⊒⃻䈏᦭ᗧ䈮ଦㅴ䈘䉏䋬ⷺൻ䈱䊙䊷䉦䊷䈪䈅䉎K1䋬
K10䈱⊒⃻䉅᦭ᗧ䈮ଦㅴ䈘䉏䈢䋮䇭એ਄䉋䉍䋬ၮᐩ⤑䈱᭴ᚑಽሶ䈱৻䈧䈪䈅䉎Lam332
䈲䋬ญ⣧☼⤑਄⊹䈱ⷺൻ䊶㕖ⷺൻ䉕೙ᓮ䈜䉎㊀ⷐ䈭ಽሶ䈱৻䈧䈪䈅䉎䈫䈫䉅䈮䋬䈠䈱⊒⃻䈲䋬ᱤ⡺਄⊹⚵❱ਅጀ䈮䈅䉎⚿ว⚵❱䈮೙ᓮ䈘䉏䈩䈇䉎น⢻ᕈ䈏␜
ໂ䈘䉏䈢䋮
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㸊䋮㩷ᢥ₂
1䋩 Calenic B, Greabu M, Caruntu C, Tanase C,
Battino M. Oral keratinocyte stem/progenitor
cells: specific markers, molecular signaling
pathways and potential uses. Periodontol 2000
2015; 69(1): 68-82.

࿑䇭TR146䉕rhLAM332䈪ಽൻ⺃ዉ䈚䈢㓙䈱䋬K1
䈱఺∉⚦⢩ᨴ⦡௝䈭䉌䈶䈮ቯ㊂ᕈRT-PCR䈱⚿ᨐ䉕␜䈜䋮䇭─ 120 ─日補綴会誌

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課題口演発 表⺖㗴㪐

iPS⚦⢩䉕↪䈇䈢5㪄HT2Aㆮવሶᄙဳ䉕䉅䈧⌧⌁ᤨ䊑䊤䉨䉲䉵䊛䊝䊂䊦䈱⏕┙䂾Ꮤ⿷᦭ℂᕺ 㪈㪀䋬ጟᧄℂผ 㪉㪀䋬቟ㇱ෹૫ 㪈㪀䋬᧻ᧄ⾆ᔒ 㪈㪀䋬↰ਛḰ৻ 㪊㪀䋬ศ↰⵨຦ 㪈㪀䋬੹ᴰ⎇ੱ 㪉㪀䋬⟤ፉஜੑ 㪊㪀䋬⿒᧻๺࿯ 㪋㪀䋬ጟ㊁ᩕਯ 㪉㪀䋬㚍႐৻⟤ 㪈㪀㪈㪀ᤘ๺ᄢቇᱤ⑼⵬✄ቇ⻠ᐳ䋬㪉㪀ᘮᙥᄢቇකቇㇱ↢ℂቇᢎቶ䋬㪊㪀ᤘ๺ᄢቇญ⣧∛ᘒ⸻ᢿ⑼ቇ⻠ᐳญ⣧∛ℂቇㇱ㐷䋬 㪋㪀㗅ᄤၴᄢቇකቇ⎇ⓥ⑼䉭䊉䊛䊶ౣ↢ක≮䉶䊮䉺䊷
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Sleep bruxism model with 5-HT2A polymorphism using iPS cells
Hoashi Y 1), Okamoto S 2), Abe Y 1), Matsumoto T 1), Tanaka J 3), Yoshida Y 1), Imaizumi K 2), Mishima K 3),
Akamatsu W 4), Okano H 2), Baba K 1)
1)
Department of Prosthodontics, Showa University, 2)Department of Physiology, School of Medicine, Keio
University, 3)Division of Pathology, Department of Oral Diagnostic Sciences, Showa University, 4)Center
for Genomic and Regenerative Medicine, School of Medicine, Juntendo University㸇䋮㩷⋡⊛⌧⌁ᤨ䊑䊤䉨䉲䉵䊛䋨SB䋩䈫ㆮવ⊛ⷐ࿃䈱㑐ㅪ䈮䈧䈇䈩䈲䋬ⴊ✼㑐ଥ䉕ၮ⋚䈫䈚䈢⎇ⓥ䉋䉍ផ⺰䈘䉏䈩䈇䈢䉅䈱䈱䋬䈠䈱⊒∝䊜䉦䊆䉵䊛䈱⸃᣿䈮䈲⥋䈦䈩䈇䈭䈇䋮వⴕ⎇ⓥ䈮䉋䉍ᚒ䇱䈲ⅣႺⷐ࿃䈫ㆮવ⊛ⷐ࿃䉕
൮᜝䈚䈢SB䊥䉴䉪࿃ሶ䈱ត⚝⊛⎇ⓥ䈮䉋䉍䋬䉶䊨䊃䊆䊮㑐ㅪ䈱ㆮવሶᄙဳ䋬䉶䊨䊃䊆䊮2Aฃኈ૕ㆮવሶ5㪄
HT2A䈱SNP䋨৻Ⴎၮᄙဳ䋩rs6313䈏SB䈫᦭ᗧ䈮㑐ㅪ䈚䋬rs6313䈱C䉝䊧䊦଻࿃⠪䈱SB⊒∝䊥䉴䉪䈏⚂4୚䈪䈅䉎䈖䈫ႎ๔䈚䈢1㪀䋮䈚䈎䈚䋬೨㗡೨⊹⾰䉇೨㗡⪲䈭䈬䈱⣖ౝ䈮ᐢ䈒ಽᏓ䈜䉎䉶䊨䊃䊆䊮2Aฃኈ૕䈫SB䈫䈱ᯏ⢻⊛䈭㑐ㅪᕈ䉕↢૕䈪ᬌ⸽䈜䉎䈖䈫䈲ਇน⢻䈪䈅䉎䋮ㄭᐕ䋬ᕆㅦ䈮ㅴዷ䈚䈢ੱᎿᄙ⢻ᕈᐙ⚦⢩䋨iPS⚦⢩䋩ᛛⴚ䈲䋬ౣ↢ක≮䉇ഃ⮎䋬∔ᖚ䈱ၮ␆⊛⎇ⓥ䈭䈬䈮ᔕ↪น⢻䈪䈅䉎䋮ᧄ⎇ⓥ䈱⋡⊛䈲䋬SBᖚ⠪䈍䉋䈶ஜᏱᚑੱ䈎䉌iPS⚦⢩䉕᮸┙䈚䋬5㪄HT2Aㆮવሶ䉕⊒⃻䈜䉎␹⚻⚦⢩䉕⺃ዉ䈚䈩䋬ᯏ⢻⊛㑐ㅪᕈ䉕ᬌ⸛น⢻䈭SB∔ᖚ䊝䊂䊦䉕᭴▽䈜䉎䈖䈫䈪䈅䉎䋮䇭㸈䋮㩷ᣇᴺ໧⸻䋬ญ⣧ౝᬌᩏ䈮䉋䉍SB⥃ᐥ⸻ᢿ䉕ⴕ䈇䋬ຏ╭╭ᵴേ᷹ቯ䉕฽䉃⌧⌁䊘䊥䉫䊤䊐ᬌᩏ䈮䉋䈦䈩⏕ቯ⸻ᢿ䈱䈧䈇䈢䋬SB䈭䉌䈶䈮Controlⵍ㛎⠪⟲䉕ኻ⽎䈫䈚
䈩SNP⸃ᨆ䉕ⴕ䈦䈢䋮SB⟲䈎䉌rs6313䈱C䉝䊧䊦଻࿃⠪2ฬ䋬Control⟲䈎䉌SB⟲䈫ᐕ㦂䈏䊙䉾䉼䈜䉎C䉝䊧䊦㕖଻࿃⠪2ฬ䉕ㆬᛯ䈚䈢䋮䈖䉏䉌䈱ⵍ㛎⠪䈱ᧃ᪳㕒⣂ⴊ䈎䉌ⴊ⃿⚦⢩䉕ណข䈚䋬ೋᦼൻ࿃ሶ䋨OCT3㪆4䋬
SOX2䋬KLF4䋬LIN28䋬L㪄MYC䋩䉕↪䈇䈩iPS⚦⢩䉕᮸┙䈚䈢䋮᮸┙䈚䈢iPS⚦⢩䈎䉌䈠䉏䈡䉏3䈧䈱䉶䊦䊤䉟䊮䉕ㆬᛯ䈚䋬ຠ⾰䉼䉢䉾䉪㩿ᧂಽൻ䊙䊷䉦䊷⊒⃻䋬ਃ⢦⪲ಽൻ䈱⸃ᨆ䋬ᩭဳ⸃ᨆ㪀䉕ⴕ䈦䈢䋮㩷iPS⚦⢩䈎䉌␹⚻⚦⢩䈻䈱⺃ዉ䈲䋬Wnt䋬RA䋬Shh䉲䉫䊅䊦䉕⺞▵䈜䉎⮎೷䈱Ớᐲ䉕ᄌൻ䈘䈞䉎䈖䈫䈪䋬ਛᨔ␹⚻䈱೨ᓟゲ䋬⢛⣻ゲ䈮ᴪ䈦䈢㗔ၞ․⇣⊛䈭␹⚻⚦⢩䉕⺃ዉ䈜䉎Imaizumi╬䈱ᣇᴺ䉕↪䈇2㪀䋬䉶䊨䊃䊆䊮␹⚻⚦⢩䈏ᄙ䈒ሽ࿷䈜䉎❔✢ᩭ㗔ၞ䈮ነ䈞䈢␹⚻⚦⢩䉕⺃ዉ䈚䈢䋮⺃ዉ䈚䈢␹⚻⚦⢩䈮ኻ䈚䈩䋬఺∉ᨴ⦡䉕ⴕ䈇䉶䊨䊃䊆䊮␹⚻⚦⢩䉕⏕⹺䈚䋬qRT㪄PCR䈮䉋䉍HTR2A䈱
⊒⃻䉕⏕⹺䈚䈢䋮
䇭ዏᧄ⎇ⓥ䉕ⴕ䈉䈮䈅䈢䉍ᤘ๺ᄢቇ䊍䊃䉭䊉䊛䊶ㆮવሶ
⸃ᨆ୶ℂክᩏᆔຬળ䋨ᛚ⹺⇟ภ179ภ䋩෸䈶䋬ᘮᙥᄢቇකቇㇱ୶ℂᆔຬળ䋨ᛚ⹺⇟ภ20080016ภ䋩䈱ᛚ⹺䉕ᓧ䈩ⴕ䈦䈢㪅
䇭㸉䋮㩷⚿ᨐ䈫⠨ኤ
SB䈭䉌䈶䈮Control䈱ోⵍ㛎⠪䋨4ฬ䋩䈱ᧃ᪳㕒⣂ⴊ䋬ⴊ⃿⚦⢩䈎䉌iPS⚦⢩䉕᮸┙䈜䉎䈖䈫䈮ᚑഞ䈚䈢䋮䉁䈢䋬᮸┙䈚䈢iPS⚦⢩䉋䉍⺃ዉ䈚䈢␹⚻⚦⢩䈮䉶䊨䊃䊆䊮␹⚻䈏฽䉁䉏䉎䈖䈫䈏఺∉ᨴ⦡䈮䉋䉍⏕⹺䈘䉏䋬qRT㪄PCR䈮䉋䉍HTR2A⊒⃻␹⚻⚦⢩䈏฽䉁䉏䉎䈖䈫䈏⏕⹺䈘䉏䈢䋮䈘䉌䈮䋬䈖䉏䉌䈱␹⚻⚦⢩䈱rs6313ㆮ
વሶဳ䈏଻ሽ䈘䉏䈩䈇䉎䈖䈫䈏⏕⹺䈘䉏䈢䋮䇭ᧄ⎇ⓥ䈮䉋䉍iPS⚦⢩䉕↪䈇䈢䊍䊃SB∔ᖚ䊝䊂䊦䈏ೋ䉄䈩᭴▽䈘䉏䈢䋮ᧄ䊝䊂䊦䈲SB䈱∔ᖚ䊜䉦䊆䉵䊛⸃᣿䈱䈢䉄䈮ᄢ䈐䈭ᓎഀ䉕ᜂ䈉䈫ᦼᓙ䈘䉏䋬੹ᓟ䋬䈖䈱䊝䊂䊦䉕↪䈇䈩ㆮવሶဳ䈮․⇣⊛䈭⚦⢩䈱ᯏ⢻․ᕈ䉇⴫⃻ဳ䉕ᬌ⸛䈜䉎੍ቯ䈪䈅䉎䋮䈘䉌䈮䋬HTR2A䈱ㆮવሶᄙဳ䈲᭽䇱䈭♖␹␹⚻㓚ኂ䉇⌧⌁㓚ኂ䈫䈱㑐ㅪ䈏ႎ๔䈘䉏䈩䈍䉍䋬ᧄ⎇ⓥᚑᨐ䈲䈖䉏䉌䈱㗔ၞ䈻䈱ᔕ↪䈏น⢻䈪䈅䉍䋬䈠䈱ᵄ෸ലᨐ䉅ᄢ䈐䈇䈫⠨
䈋䉌䉏䉎䋮
䇭
㸊䋮㩷ᢥ₂
1䋩 Abe Y, Suganuma T, Ishii M, Yamamoto G,
Gunji T, Clark GT, et al. Association of genetic,
psychological and behavioral factors with sleep
bruxism in a Japanese population. J Sleep Res.
2012;21(3):289-96
2䋩 Imaizumi K, Sone T, Ibata K, Fujimori K,
Yuzaki M, Akamatsu W, et al. Controlling theRegional Identity of hPSC-Derived Neurons to
Uncover Neuronal Subtype Specificity of
Neurological Disease Phenotypes. Stem Cell
Reports. 2015;5(6):1010-22.

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