炎症・免疫研究部
1.

Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, J Sagara,Nakayama J, Taniguchi S, Ikeda U. Critical role of bone marrow-derived ASC, an
inflammasome adaptor molecule, in neointimal formation after vascular injury in mice.
Circulation 117, 3079-3087 (2008).
https://www.ncbi.nlm.nih.gov/pubmed/18541743

2.

Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, TakahashiY, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S,Ikeda U. Inflammasome activation of cardiac fibroblasts is essential for myocardialischemia reperfusion injury. Circulation 123, 594-604 (2011).
(Circulation's Best Paper Award of Basic Science 2011)https://www.ncbi.nlm.nih.gov/pubmed/21282498

3.

Inoue Y, Shirasuna K, Kimura H, Usui F, Kawashima A, Karasawa T, Tago K, Dezaki K,
Nishimura S, Sagara J, Noda T, Iwakura Y, Tsutsui H, Taniguchi S, Yanagisawa K, YadaT, Yasuda Y, Takahashi M. NLRP3 regulates neutrophil function and contributes tohepatic ischemia-reperfusion injury independently of inflammasomes. J Immunol 192,4342-4351 (2014).
https://www.ncbi.nlm.nih.gov/pubmed/24696236

4.

Komada T, Usui F, Shirasuna K, Kawashima A, Kimura H, Karasawa T, Nishimura S,
Sagara J, Noda T, Taniguchi S, Muto S, Nagata D, Kusano E, Takahashi M. ASC in renalcollecting duct epithelial cells contributes to inflammation and injury after unilateral
ureteral obstruction. Am J Pathol 184, 1287-1298 (2014).
https://www.ncbi.nlm.nih.gov/pubmed/24606883

5.

Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T, Yoshimura K,Aoki H, Tsustui H, Noda T, Sagara J, Taniguchi S, Takahashi M. Inflammasome
activation by mitochondrial oxidative stress in macrophages leads to the developmentof angiotensin II-induced aortic aneurysm. Arterioscler Thromb Vasc Biol 35, 127-136(2015).
https://www.ncbi.nlm.nih.gov/pubmed/25378412

6.

Mizushina Y, Shirasuna K, Usui F, Karasawa T, Kawashima A, Kimura H, Kobayashi M,Komada T, Inoue Y, Mato N, Yamasawa H, Latz E, Iwakura Y, Kasahara T, Bando M,Sugiyama Y, Takahashi M. NLRP3 protein deficiency exacerbates hyperoxia-inducedlethality through Stat3 protein signaling independent of interleukin-1beta. J Biol Chem
290, 5065-5077 (2015).
https://www.ncbi.nlm.nih.gov/pubmed/25548278

7.

Sadatomo A, Inoue Y, Ito H, Karasawa T, Kimura H, Watanabe S, Mizushina Y,Nakamuara J, Kamata R, Kasahara T, Horie H, Sata N, Takahashi M. Interaction ofneutrophils with macrophages promotes interleukin-1β maturation and contributes tohepatic ischemia-reperfusion injury. J Immunol 199, 3306-3315 (2017).
https://www.ncbi.nlm.nih.gov/pubmed/28972095

8.

Kawashima A, Karasawa T, Tago K, Kimura H, Kamata R, Usui-Kawanishi F, Watanabe
S, Ohta S, Funakoshi-Tago M, Yanagisawa K, Kasahara T, Suzuki K, Takahashi M.
ARIH2 ubiquitinates NLRP3 and negatively regulates NLRP3 inflammasome activationin macrophages. J Immunol 199, 3614-3622 (2017).
https://www.ncbi.nlm.nih.gov/pubmed/29021376

9.

Karasawa T, Kawashima A, Usui-Kawanishi F, Watanabe S, Kimura H, Kamata R,
Shirasuna K, Koyama Y, Sato-Tomita A, Matsuzaka T, Tomoda H, Park SY, Shibayama
N, Shimano H, Kasahara T, Takahashi M. Saturated fatty acids undergo intracellular
crystallization and activate the NLRP3 inflammasome in macrophages. Arterioscler
Thromb Vasc Biol 38, 744-756 (2018).
https://www.ncbi.nlm.nih.gov/pubmed/29437575

10. Mizushina Y, Karasawa T, Aizawa K, Kimura H, Watanabe S, Kamata R, Komada T,Mato N, Kasahara T, Koyama S, Bando M, Hagiwara K, Takahashi M. Inflammasomeindependent and atypical processing of IL-1β contributes to acid aspiration-induced
acute lung injury. J Immunol 203, 236-246 (2019).
https://www.ncbi.nlm.nih.gov/pubmed/31109954