ACIST Diastolic Pressure Ratio (dPR)
Non-hyperemic index for coronary physiology

Reducing costs, time and patient discomfort
ACIST diastolic pressure ratio (dPR), using the ACIST RXi® Rapid Exchange System,
provides a non-hyperemic alternative for physiological assessment of coronary disease.
Non-hyperemic pressure ratios, such as dPR, may reduce patient discomfort*, cost**
and procedural time.***ReducedPatient Discomfort

Reduced
Cost

ACIST RXi® Rapid
Exchange System
Uses Navvus MicroCatheter, the go-to
alternative to traditional pressure wires,
enabling the physician to use their0.014” guidewire of choice for reliable
assessment of coronary physiology.

ReducedTimeACIST dPR algorithm
ACIST dPR is the ratio of Pd to Pa at the peak-to-peak midpoint, averaged
over 5 consecutive heartbeats. ACIST dPR does not rely on an ECG signal to
make the calculation.
Pd/Pa at midpoint of peak topeak averaged over 5 beats

mmHg

12080
PdPa013245Seconds

ACIST dPR by the numbers (compared to iFRcalc)10.89

dPR cutpoint

Bracco Group0.999
AUC

98.3% 99.2% 98.3% 99.2%
Sensitivity

Specificity

PPVNPVACIST Diastolic Pressure Ratio (dPR)

Analysis of the ACIST FFR Study1Purpose

Key points

The data collected during the ACIST-FFR clinical study wasretrospectively assessed by an independent, physiologic
core laboratory to support ACIST’s dPR algorithm on theACIST RXi system.

• ACIST dPR is highly correlated with iFRcalc• ACIST dPR provides similar diagnostic
accuracy as iFRcalc

Methods
The dPR value was calculated by the application of ACIST’s
fully automated off-line dPR software algorithm. iFRcalc wascalculated off-line, by the same core lab, based on the originaldescription of its derivation to determine a final value for iFR.2

sites

179

patients

Results

Diagnostic accuracy of dPR(cutpoint of 0.89) referenced toiFRcalc (0.89) was 98.88%

dPR

11

Passing-Bablok Comparison betweendPR (cutpoint 0.89) and iFRcalc (0.89)
2.0
1.9
1.8
1.7
1.6
1.5
1.4
1.3
1.2
1.1
1.0
0.9
0.8
0.7
0.6
0.5
0.4
0.3
0.2
0.1
0.0

Passing-Bablok: y=-0.0213 + 1.0200x

0.0

0.2

0.4

0.6

0.8

1.0

1. 2

1.4

1.6

iFR
Identity

PBfit

Learn more about ACIST dPR* and the Navvus® Rapid Exchange Pressure MicroCatheter at ACIST.com*ACIST dPR is available in select markets*Cost savings based on the reduced cost of utilizing a resting approach compared to conventional FFR and respective cost of administration ofhyperemic agent (adenosine).
** when comparing resting index (iFR, dPR, Pd/Pa) to FFR with adenosine induced hyperemia*** Reduced side effect profile when comparing resting approach (iFR, dPR, Pd/Pa) to FFR with adenosine induced hyperemia
1. Data on file TR-07879
2. Sen S, Escaned J, Malik IS, et al. Development and validation of a new adenosine-independent index of stenosis severity fromcoronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study. J Am Coll Cardiol.
2012;59(15):1392-1402. doi:10.1016/j.jacc.2011.11.003.
ACIST, ACIST RXi and Navvus are trademarks of ACIST Medical Systems, Inc. ACIST Medical Systems, Inc., reserves the right to modify thespecifications and features described herein, or discontinue manufacture of the product described at any time without prior notice or obligation.
Please contact your authorized ACIST representative for the most current information.
© 2020 ACIST Medical Systems, Inc. All Rights Reserved. P/N: 30-100121 09/20 Rev 1

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