第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1─3─1

ࣃࣛࢱࣝࣂ࣮ࡢタᐃ఩⨨࡟㛵ࡍࡿᐇ㦂ⓗ◊✲㸫␗≀ឤ࣭㞀ᐖឤࡢᛂ⏝㸫‫ۑ‬ୗᕝཎ ᚸ㸪᭮᰿ᓠୡ㸪ᯇᕝ㧗᫂㸪㇏⏣᭷⨾Ꮚ㸪ᯇ஭⸛᭷⨾㸪Ⲩ㔝㈗⾜㸪኱ᕝ ✨㸪ᰁᕝṇከ㸪ቑ⏣⨾⮳㸪ᒸᮏ࿴ᙪ㸪኱ᕝ࿘἞᫂ᾏ኱ᏛṑᏛ㒊ᶵ⬟ಖᏑᅇ᚟Ꮫㅮᗙṑ⛉⿵⥛Ꮫศ㔝
Experimental Studies on Location of Palatal Bar-Apprication of Discomfort and Difficulty in Oral Functions Shimokawara S㸪Sone S㸪Matsukawa T㸪Toyota Y㸪Matsui A㸪Arano T㸪Okawa Y㸪Somekawa S㸪
Masuda M㸪 Okamoto K㸪Ohkawa S
Division of Removable Prosthodontics㸪Department of Restorative & Biomaterials Sociences㸪Meikai
University School of DentistryϨ㸬 ┠ⓗ 㒊ศᗋ⩏ṑ⿵⥛࡟࠾࠸࡚㸪୧ഃฎ⌮ࡢタィࡣ⩏ṑࡢᏳᐃࡸᨭྎṑࡢ㈇ᢸ㍍ῶࢆᅗࡿୖ࡛㔜せ࡛࠶ࡿ㸬ୖ㢡㒊ศᗋ⩏ṑࡢ୧ഃฎ⌮࡟㢖⏝ࡉࢀࡿࣃࣛ
ࢱࣝࣂ࣮ࡣ㸪ࡑࡢタᐃ఩⨨࡟ࡼࡗ࡚ࡣ㐪࿴ឤࢆ⏕ࡌࡓࡾ1)㸪Ⓨ㡢ࡸ࿪ᄮࢆ㜼ᐖࡍࡿ2)ࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࡀ㸪㐺ษ࡞タᐃ఩⨨࡟㛵ࡋ࡚ࡣ୙᫂࡞Ⅼࡀṧࡉࢀ࡚࠸ࡿ㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪⿕㦂⪅ࡢ୺ほⓗホ౯ࢆ⏝࠸㸪ᶵ⬟㐠ື᫬࡟࠾ࡅࡿ␗≀ឤ࠾ࡼࡧ㞀ᐖឤࢆᛂ⏝ࡋ࡚㸪ࣃࣛࢱࣝࣂ࣮ࡢ㐺ษ࡞タᐃ఩⨨ࢆ᳨ウࡍࡿࡇ࡜࡛࠶ࡿ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣ㢡ཱྀ⭍⣔࡟ᶵ⬟␗ᖖ࠾ࡼࡧឤぬ㞀ᐖࢆㄆࡵࡎ㸪ಶᛶṇᖖညྜࢆ᭷ࡍࡿ೺ᖖ᭷ṑ㢡⪅62ྡ࡜ࡋࡓ㸬㒊ศᗋ⩏ṑࢆ᝿ᐃࡋ㸪タᐃ఩⨨ࡢ␗࡞ࡿ3✀ࡢᐇ㦂⏝ࣃࣛࢱࣝࣂ࣮ ௨ୗ㸪ࣂ࣮ ࢆ⏝࠸ࡓ㸬ࡍ࡞ࢃࡕ㸪➨୍ᑠ⮻ṑ㛫ࢆ๓ṑ㒊ཱྀ⵹ഃṑ⫗⦕࡜ᖹ⾜࡟㉮⾜ࡍࡿࢱ࢖ࣉ ௨ୗ㸪Aᆺ 㸪➨஧ᑠ⮻ṑ㛫ࢆ㉮⾜ࡍࡿࢱ࢖ࣉ ௨ୗ㸪Mᆺ 㸪࠾ࡼࡧ➨஧኱⮻ṑ㛫ࢆ㉮⾜ࡍࡿࢱ࢖ࣉ ௨ୗ㸪Pᆺ ࡢ3✀࡜ࡋ㸪ຍ⇕㔜ྜᆺᗋ⏝ࣞࢪࣥ ࢼࢳࣗࣛࣝࣞࢪࣥ㸪ࢽࢵࢩࣥ ࢆ⏝࠸࡚స〇ࡋࡓ㸬ࣂ࣮ࡢᙧែࡣ࠿ࡲࡰࡇᆺ㸪ᑍἲࡣཌࡉ1.5mm㸪ᖜ7.0mm࡜ࡋ㸪㎶⦕࡟ࡣ⛣⾜ⓗ࡞ᙧែࢆ௜୚ࡋࡓ㸬ࡲࡓ㸪◊✲⏝ᶍᆺࢆ⏝࠸࡚㸪ཱྀ⵹῝ࡉࢆィ ࡋ㸪ཱྀ⵹῝ࡉࡢ῝࠸ࢢ࣮ࣝࣉࢆD⩌㸪ὸ࠸ࢢ࣮ࣝࣉࢆS⩌࡜ࡋ㸪ཱྀ⵹๓᪉㒊࠾ࡼࡧཱྀ⵹ᚋ᪉㒊࡟࠾ࡅࡿཱྀ⵹῝ࡉࡢࣃࢱ࣮ࣥศ㢮ࡶ⾜ࡗࡓ㸬ホ౯㡯┠ࡣ㸪 1 ࣂ࣮ࢆ⿦╔ࡋ㸪Ᏻ㟼≧ែࢆ࡜ࡽࡏࡿ ௨ୗ㸪R 㸪 2 ࠕᱜࡢⰼࡀဏࡁࡲࡋࡓࠖ࠾
ࡼࡧ࢝⾜㸪ࢧ⾜㸪ࢱ⾜㸪ࣛ⾜ࡢⓎ㡢 ௨ୗ㸪Sp 㸪
3 ࣆ࣮ࢼࢵࢶࡢ࿪ᄮ ௨ୗ㸪Cw  4 ࣆ࣮ࢼࢵࢶ
ࡢᄟୗ ௨ୗ㸪Sw ࡢ4㡯┠࡜ࡋ㸪ࡑࡢ㝿ࡢ␗≀ឤ࠾ ࡼ ࡧ 㞀 ᐖ ឤ ࢆ 11 ẁ 㝵 ࡢ Numerical Rating
Scale(NRS)࡟ࡼࡾࢫࢥ࢔໬ࡋࡓ㸬⤫ィฎ⌮ࡣ㸪ࣂ࣮ࡢタᐃ఩⨨ࡀ␗≀ឤ࠾ࡼࡧ㞀ᐖឤ࡟ཬࡰࡍᙳ㡪࡟ࡘ࠸୍࡚ඖ㓄⨨ศᩓศᯒᚋ㸪ከ㔜ẚ㍑᳨ᐃ
㸦Scheffeἲ㸧ࢆ⾜࠸㸪ཱྀ⵹๓᪉㒊࠾ࡼࡧᚋ᪉㒊࡛ࡢཱྀ⵹῝ࡉࡢࣃࢱ࣮ࣥࡀ␗≀ឤ࠾ࡼࡧ㞀ᐖឤ࡟ཬࡰࡍᙳ㡪࡟ࡘ࠸࡚ࡣ஧ඖ㓄⨨ศᩓศᯒࢆ⾜ࡗࡓ㸬᭷ពỈ‽ࡣ5%࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ࣂ࣮ࡢ๓ᚋⓗ఩⨨㛵ಀ Aᆺ㸪Mᆺ㸪Pᆺ ࡣ㸪␗≀ឤ࠾ࡼࡧ㞀ᐖឤ࡟᭷ព࡞ᙳ㡪ࢆཬࡰࡋࡓࡀ㸪ཱྀ⵹῝ࡉࡢ┦㐪ࡣ␗≀ឤ࠾ࡼࡧ㞀ᐖឤ࡟᭷ព࡞ᙳ㡪ࢆཬࡰࡉ࡞࠿ࡗࡓ㸬ࣂ࣮⿦╔┤ᚋ࡟࠾࠸࡚㸪Spࢆ
㝖ࡃࡍ࡭࡚ࡢホ౯㡯┠࡟࠾࠸࡚㸪Pᆺࡀ᭷ព࡟㧗࠸ࢫࢥ࢔ࢆ♧ࡋࡓ㸬ࣂ࣮⿦╔┤ᚋࡢCw࠾ࡼࡧSw࡟࠾
࠸࡚ࡣAᆺࡀ㸪Mᆺ࠾ࡼࡧPᆺ࡜ẚ㍑ࡋ࡚᭷ព࡟ᑠ
ࡉࡃ㸪Sp࡟࠾࠸࡚ࡣMᆺࡀ㸪Aᆺ࠾ࡼࡧPᆺ࡜ẚ㍑
ࡋ࡚᭷ព࡟ᑠࡉ࠸ࢫࢥ࢔ࢆ♧ࡋࡓ㸬 ௨ୖࡼࡾ㸪ࣃࣛࢱࣝࣂ࣮ࡢタᐃ఩⨨ࡣཱྀ⵹῝ࡉࡢᙳ㡪ࡼࡾࡶ๓ᚋⓗ఩⨨㛵ಀ࡟ࡼࡿᙳ㡪ࡢ᪉ࡀ኱ࡁࡃ㸪࠿ࡘཱྀ⵹୰ኸ࡟タᐃࡍࡿࡢࡀ᭱ࡶ㐺ษ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬
Sp
RR

Cw

Sw

㸨㸸ࣂ࣮ࡢタᐃ఩⨨࡜␗≀ឤ࣭㞀ᐖឤࡢࢫࢥ࢔ϫ㸬 ᩥ⊩
1)Farrell J㸬Partial denture tolerance㸬Dent Pract
Dent Rec 1969;19:162-164㸬
2㸧 㛵ሯᘺᑑኵ㸬ୖ㢡⩏ṑཱྀ⵹㒊ࡢタィ᮲௳ࡀ⯉࡟ࡼࡿ␗≀ឤ࡟ཬࡰࡍᙳ㡪࡟㛵ࡍࡿᐇ㦂ⓗ◊✲㸬ṑ⛉Ꮫሗ 1973;73:1044-1065㸬

− 132 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1─3─2

㒊ศᗋ⩏ṑ⿦╔⪅࡟࠾ࡅࡿᗋୗ⢓⭷③ࡢࣜࢫࢡࣇ࢓ࢡࢱ࣮
‫⇃ۑ‬㇂ຬே㸪Ἑ㔝ⱥᏊ㸪➜ᮌ㈼἞㸪ⱝᯘ๎ᖾᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉ 㒊ศᗋ⩏ṑ⿵⥛Ꮫศ㔝
Risk Factors for Denture-Related Mucosal Pain in Removable Partial Denture Wearers
Kumagai H, Kohno E, Fueki K, Wakabayashi N
Department of Masticatory Function Rehabilitation, Tokyo Medical and Dental UniversityϨ㸬 ┠ⓗ ⩏ṑ⿦╔⪅࡟࠾࠸࡚㸪⩏ṑᗋୗ⢓⭷ࡢ③ࡳࡣ㢖ᗘࡢ㧗࠸ၥ㢟ࡢ୍ࡘ࡛࠶ࡿ㸬≉࡟㒊ศᗋ⩏ṑ⿦╔⪅࡟࠾࠸࡚ࡣ඲㒊ᗋ⩏ṑ⿦╔⪅ࡼࡾࡶ③ࡳࢆ᭷ࡍࡿ๭ྜࡀ㧗ࡃ㸪ࡲࡓ③ࡳࡢᨵၿ࡟ࡶ᫬㛫ࢆせࡍࡿ㸯㸧㸬ᗋୗ⢓⭷ࡢ③ࡳࢆࢥࣥࢺ࣮ࣟࣝࡋ㍍ῶࡉࡏࡿࡇ࡜ࡣ⮫ᗋୖ㔜せ࡞ព⩏ࢆᣢࡘ࡜⪃࠼ࡽࢀࡿࡀ㸪࡝ࡢࡼ࠺࡞ᅉᏊࡀᗋୗ⢓⭷ࡢ③ࡳࢆᘬࡁ㉳ࡇࡍࣜࢫࢡࣇ࢓ࢡࢱ࣮࡜࡞ࡿ࠿᫂ࡽ࠿࡛ࡣ࡞࠸㸬ᮏ◊✲࡛ࡣ㒊ศᗋ⩏ṑ⿦╔⪅ࢆᑐ㇟࡟㸪ᝈ⪅ᅉᏊ࠾ࡼࡧ
⩏ṑ㛵㐃ᅉᏊ࡜ᗋୗ⢓⭷③࡜ࡢ㛵㐃ࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲᮾி་⛉ṑ⛉኱ᏛṑᏛ㒊㝃ᒓ⑓㝔⩏ṑእ᮶࡟㏻
㝔ࡍࡿ㒊ศᗋ⩏ṑ⿦╔⪅171ྡ㸦⏨ᛶ62ྡ㸪72.1s
8.1ṓ㸪257ᗋ㸧ࢆ⿕㦂⪅࡜ࡋࡓ㸬㢡ཱྀ⭍㡿ᇦ࡟ᛴᛶ⑕≧ࢆ᭷ࡍࡿሙྜࡣᑐ㇟࠿ࡽ㝖እࡋࡓ㸬ྛ⿕㦂⪅ࡣ㸪౑⏝୰ࡢ⩏ṑ࡟ࡘ࠸࡚㸪ホ౯᫬Ⅼ࡟࠾ࡅࡿᗋୗ⢓⭷ࡢ③ࡳࡢ᭷↓㸪࠾ࡼࡧ᪂〇᫬࠿ࡽホ౯᫬Ⅼࡲ࡛ࡢᮇ㛫࡟࠾ࡅࡿ③ࡳ⤒㦂ࡢ᭷↓ࢆホ౯ࡋࡓ㸬ࡲࡓ③ࡳ࡟㛵㐃ࡍࡿ࡜⪃࠼ࡽࢀࡿᅉᏊ
࡜ࡋ࡚㸪ᝈ⪅ᅉᏊ㸸ᖺ㱋㸪ᛶู㸪≧ែ࣭≉ᛶ୙Ᏻ
㸦State-Trait Anxiety Inventory (STAI)㸧㸪᭱኱ညྜ
ຊ[N]㸪⢓⭷ᅽ③㜈್㸦Pressure Pain Threshold; PPT[N]㸧㸪ཱྀ⭍஝⇱⮬ぬ㢖ᗘ㸦0-4㸧㸪ሀᅛ㣗ရᦤྲྀ㢖ᗘ㸦0-4㸧㸪᪥୰࠾ࡼࡧኪ㛫ࣃࣛࣇ࢓ࣥࢡࢩࣙࣥ
⮬ぬ㢖ᗘ㸦ྛ0-4㸧㸪ṧᏑṑ࡟ࡼࡿညྜᨭᣢᩘ㸪Ḟᦆ㒊㢡ሐᙧែ㸦᩿㠃ᙧែ࣭㠃✚࣭㉮⾜࣭௜╔ṑ⫗ࡢ఩ ⨨ࡢ ྜィࢫࢥ࢔㸸0-12㸧㸪Ḟᦆ㒊㢡ሐ⢓⭷㸦ᡭᣦᅽ࡟ࡼࡿ⿕ᅽ⦰ᛶ㸸0-3㸪Ⓨ㉥㸪᧿㐣യ㸪₽⒆ࡢ᭷↓㸧㸪࠾ࡼࡧ⩏ṑ㛵㐃ᅉᏊ㸸⿦╔㢡㸦ୖ㸭ୗ㸧㸪✀㢮㸦᭱⤊⩏ṑ㸭἞⒪⏝⩏ṑ㸧㸪⩏ṑ౑⏝ᮇ㛫㸦᭶㸧㸪⿦╔⩦័㸦᪥୰ᖖ᫬㸭ᚲせ᫬ࡢࡳ㸧㸪Ᏻᐃᛶ㸦ᡭᣦ࡟ࡼࡗ࡚ேᕤṑ㒊ࢆຍᅽࡋࡓ࡜ࡁࡢ
ࣞࢫࢺࡢᾋࡁୖࡀࡾࡢ᭷↓㸧㸪Ḟᦆṑᩘ㸪ᨭྎṑᩘ㸪Ḟᦆṑᩘ࡟ᑐࡍࡿᨭྎṑᩘ㸪ညྜ᥋ゐ⥲㠃✚[mm2]࠾ࡼࡧᕥྑẚ㸪ࢆホ౯⪅㸯ྡࡀホ౯ࡋࡓ㸬ୖグኚᩘ࡟ࡘ࠸࡚ࢫࣆ࢔࣐ࣥࡢ┦㛵ಀᩘࢆ⟬ฟࡋ㸪ḟ࡟ホ౯᫬Ⅼ࡟࠾ࡅࡿ③ࡳࡢ᭷↓㸪ࡲࡓࡣ⩏ṑ౑⏝ᮇ㛫࡟࠾ࡅࡿ③ࡳ⤒㦂ࡢ᭷↓ࢆᚑᒓኚᩘ㸪③ࡳࡢᅉᏊࢆ⊂❧ኚᩘ࡜ࡍࡿࣟࢪࢫࢸ࢕ࢵࢡᅇᖐ
ศᯒ㸦ኚᩘቑຍἲ㸧ࢆ⾜ࡗࡓ㸬ከ㔜ඹ⥺ᛶࢆᅇ㑊ࡍࡿࡓࡵ㸪⊂❧ኚᩘ㛫ࡢࢫࣆ࢔࣐ࣥࡢ┦㛵ಀᩘࡀ㸪ᚑᒓኚᩘ࡜⊂❧ኚᩘ࡜ࡢ┦㛵ಀᩘࡼࡾࡶ┦ᑐⓗ࡟኱ࡁ࠸ሙྜࡣ㸪ᚑᒓኚᩘ࡜ࡢ┦㛵ಀᩘࡀᑠࡉ࠸࡯
࠺ࡢ⊂❧ኚᩘࢆᅇᖐศᯒ࠿ࡽ㝖እࡋࡓ㸬⤫ィゎᯒ࡟ࡣSPSS ver 16.0ࢆ⏝࠸㸪᭷ពỈ‽ࡣ
P=0.05࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ホ౯᫬Ⅼ࡟࠾ࡅࡿ③ࡳࡢ᭷↓ࡢ᭷ព࡞⊂❧ኚᩘ
࡜ࡋ࡚㸪PPT㸦࢜ࢵࢬẚ0.99㸪P=0.002㸧㸪㢡ሐ⢓⭷ࡢ⿕ᅽ⦰ᛶ㸦0.17㸪P<0.001㸧㸪ཱྀ⭍஝⇱㸦1.97,
P=0.001 㸧 㸪 ᪥ ୰ ࣃ ࣛ ࣇ ࢓ ࣥ ࢡ ࢩ ࣙ ࣥ 㸦 2.29,
P<0.001㸧㸪⩏ṑࡢ✀㢮㸦2.90, P=0.005㸧㸪⩏ṑ౑⏝ᮇ㛫㸦0.99㸪P=0.005㸧ࡀ᳨ฟࡉࢀࡓ㸬③ࡳ⤒㦂࡟ࡘ࠸࡚ࡶྠࡌኚᩘࡀ᭷ព࡞⊂❧ኚᩘ࡜ࡋ᳨࡚ฟ
ࡉࢀࡓ㸦PPT㸦0.99㸪P=0.003㸧㸪㢡ሐ⢓⭷ࡢ⿕ᅽ⦰ ᛶ 㸦 0.16 㸪 P<0.001 㸧 㸪 ཱྀ ⭍ ஝ ⇱ 㸦 2.00,
P=0.001 㸧 㸪 ᪥ ୰ ࣃ ࣛ ࣇ ࢓ ࣥ ࢡ ࢩ ࣙ ࣥ 㸦 2.46,
P<0.001㸧㸪⩏ṑࡢ✀㢮㸦2.90, P=0.006㸧㸪⩏ṑ౑⏝ᮇ㛫㸦0.99㸪P=0.003㸧㸧㸬ࡇࡢࡇ࡜࠿ࡽ⢓⭷ᅽ③㜈್ࡀప࠸ࡇ࡜㸪㢡ሐ⢓⭷ࡢ⿕ᅽ⦰ᛶࡀ኱ࡁ࠸
ࡇ࡜㸪ཱྀ⭍஝⇱ࡢ⮬ぬ㢖ᗘࡀ㧗࠸ࡇ࡜㸪᪥୰ࣃࣛࣇ࢓ࣥࢡࢩࣙࣥࡢ⮬ぬ㢖ᗘࡀ㧗࠸ࡇ࡜㸪౑⏝୰ࡢ⩏ṑࡀ἞⒪⏝⩏ṑ࡛࠶ࡿࡇ࡜㸪⩏ṑ౑⏝ᮇ㛫ࡀ▷࠸ࡇ࡜ࡀ㸪ᗋୗ⢓⭷③ࡢࣜࢫࢡࣇ࢓ࢡࢱ࣮࡟࡞ࡿ
ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬௨ୖ࠿ࡽ᭱⤊⩏ṑ࡟ࡼࡗ࡚⿵⥛ࡍࡿࡇ࡜ࡢ࡯࠿
࡟㸪ཷᅽ᮲௳࡛࠶ࡿ㢡ሐ⢓⭷࡬ࡢฎ⨨㸪ຍᅽᅉᏊ࡜࡞ࡾᚓࡿ᪥୰ࣃࣛࣇ࢓ࣥࢡࢩࣙࣥ࡬ࡢᑐฎࡀᗋ
ୗ⢓⭷ࡢ③ࡳࡢࢥࣥࢺ࣮ࣟࣝ࡟࠾࠸࡚ᚲせ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿ㸬ϫ㸬 ᩥ⊩1) Szentpétery AG, John MT, Slade GD et al.
Problems reported by patients before and after
prosthodontic treatment. Int J Prosthodont 2005;
18: 124-130.

− 133 −

第1日

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7･124 回特別号，2015

一般口演発表

1 ─ 3 ─ 3㐟㞳➃Ḟᦆࡀᑐྜṑ࡟୚࠼ࡿᙳ㡪‫ۑ‬᭷⏣࿘ᖹ㸪ᶒ⏣▱ஓ㸪๓⏣ⰾಙ኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉㢡ཱྀ⭍ᶵ⬟෌ᘓᏛㅮᗙ᭷ᗋ⩏ṑ⿵⥛Ꮫ࣭㧗㱋⪅ṑ⛉Ꮫศ㔝Influence of distal extension missing on occlusal force to opposing teeth.
Arita S, Gonda T, Maeda Y.
Department of Prosthodontics, Gerodontology and Oral Rehabilitation, Osaka University Graduate School of
Dentistry.

Ϩ㸬 ┠ⓗ 㐟㞳➃Ḟᦆࡢ㐍⾜࡟ࡼࡿṧᏑṑᩘࡢῶᑡ࡟క࠸㸪ṧᏑṑ࡟ຍࢃࡿညྜຊࡣቑຍࡋ㸪ࡉࡽ࡞ࡿḞᦆࡢᣑ኱࡟ࡘ࡞ࡀࡿྍ⬟ᛶࡀ࠶ࡿ࡜⪃࠼ࡽࢀ࡚࠸ࡿ1)㸬
ࡋ࠿ࡋ㸪Ḟᦆṑิ࡟࠾࠸࡚㸪ṑิ඲యࡢညྜຊ࡟
ࡘ࠸࡚ࡢሗ࿌ࡣ࠶ࡿ2)ࡶࡢࡢ㸪ṧᏑṑ1ṑ༢఩࡟ຍࢃࡿညྜຊ࡟ࡘ࠸࡚ሗ࿌ࡋࡓ◊✲ࡣ࡞࠸㸬ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪Ḟᦆṑิᑐྜṑࡢညྜ᫬ࡢࡦࡎࡳ࡟
╔┠ࡋ㸪Ḟᦆࡢቑຍ࡟క࠺ᑐྜṑ1ṑ༢఩࡟ຍࢃࡿ
ညྜຊࡢኚ໬㸪࡞ࡽࡧ࡟Ḟᦆ⿵⥛ࡀṧᏑṑ࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚㸪ᶍᆺᐇ㦂࡟ࡼࡾ᳨ウࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ ᐇ 㦂 ⏝ ᶍ ᆺ ࡣ 㸪 ୖ ୗ 㢡 ᭷ ṑ 㢡 ᶍ ᆺ 㸦 D51FE500A-QF㸪ࢽࢵࢩࣥ♫㸧ࢆ⏝࠸ࡓ㸬ձḞᦆ࡞ࡋ㸪
ղ7㹺7Ḟᦆ㸪ճ76㹺67Ḟᦆ㸪մ765㹺567Ḟᦆ㸪յ7654㹺4567Ḟᦆ㸪ն76543㹺34567Ḟᦆ㸪շ765432㹺234567Ḟᦆࡢ7✀㢮ࡢ୧ഃ㐟㞳➃Ḟᦆࢆタᐃࡋࡓ㸬 ୖ㢡୰ษṑ㸪ୖ㢡≟ṑ㸪ୖ㢡➨୍ᑠ⮻ṑ㸪ୖ㢡➨୍኱⮻ṑࡢᕥഃṑิィ4ᮏࢆ⿕㦂ṑ࡜ࡋ࡚㢋ഃ㠃࡜ཱྀ⵹ഃ㠃࡟2ᯛࡢࡦࡎࡳࢤ࣮ࢪࢆ㈞௜ࡋࡓ㸬 ᐇ㦂࡟ඛ❧ࡕ㸪4ᮏࡢ⿕㦂ṑࡢᰯṇᐇ㦂ࢆ⾜࠸㸪ညྜຊ࡜ࡦࡎࡳࡢ㛵ಀ࡟ࡘ࠸࡚ᰯṇಀᩘࢆᚓࡓ㸬 ࡲࡎ㸪7✀㢮ࡢୗ㢡㐟㞳➃Ḟᦆᶍᆺࢆᑐྜṑ࡜ည㢌ᔐྜ఩࡛ညྜࡉࡏ㸪49NࡢⲴ㔜ࢆຍ࠼ࡓ㝿ࡢྛ⿕㦂ṑࡢࡦࡎࡳࢆィ ࡋࡓ㸬 ḟ࡟㸪7✀㢮ࡢ࠺ࡕ7654㹺4567ḞᦆᶍᆺࡢḞᦆ㒊㢡ሐ࡟ཌࡉ2mmࡢᨃఝ㢡ሐ⢓⭷ࢆタᐃࡋ㸪⩏ṑࢆ〇సࡋࡓ㸬⩏ṑ⿦╔๓ᚋ࡛㸪ည㢌ᔐྜ఩࡛ညྜࡉ
ࡏ㸪49NⲴ㔜ୗ࡛ྛ⿕㦂ṑࡢࡦࡎࡳࢆィ ࡋ㸪⩏ṑ⿦╔ࡢ᭷↓࡟ࡼࡿ⿕㦂ṑࡢညྜຊࢆẚ㍑ࡋࡓ㸬 ィ ࡣ㸪ྛ᮲௳࡟ࡘࡁ6ᅇࡎࡘ⾜࠸㸪ᖹᆒࢆྛィࡢ௦⾲್࡜ࡋ㸪ᰯṇಀᩘ࡟ࡼࡾ⿕㦂ṑ࡟ຍࢃࡿ
ညྜຊ㸦N㸧ࢆồࡵࡓ㸬 ⿕㦂ṑẖ࡟㸪᮲௳㛫ࡢညྜຊࡢᕪ࡟ࡘ࠸࡚㸪
Kluskal-Wallis᳨ᐃࢆ⾜࠸㸪᭷ពᕪࢆㄆࡵࡓሙྜ࡟
ࡣBonfferoniἲ࡟࡚ከ㔜ẚ㍑ࢆ⾜ࡗࡓ(p<0.05)㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ࡲࡎ㸪ୗ㢡ࡢ7✀㢮ࡢ㐟㞳➃Ḟᦆᶍᆺ࡜ᑐྜṑࢆညྜࡉࡏࡿᐇ㦂࡛ࡣ㸪඲࡚ࡢ⿕㦂ṑ࡟࠾࠸࡚㸪Ḟᦆࡀቑຍࡍࡿ⛬㸪ᑐྜṑ1ṑ༢఩࡟ຍࢃࡿညྜຊࡣ
኱ࡁࡃ࡞ࡗࡓ㸬 ḟ࡟㸪7654㹺4567ୗ㢡㐟㞳➃Ḟᦆ࡟⩏ṑࢆ⿦╔ࡍࡿᐇ㦂࡛ࡣ㸪ୖ㢡୰ษṑ࡟࠾࠸࡚ࡣ㸪Ḟᦆ࡞ࡋ㸪⩏ṑ⿦╔㸪Ḟᦆࡢ㡰࡟ᑐྜṑ࡟ຍࢃࡿညྜຊࡀ᭷
ព࡟኱ࡁࡃ࡞ࡗࡓ㸦p<0.01㸧㸬ୖ㢡➨୍ᑠ⮻ṑ㸪ୖ㢡➨୍኱⮻ṑ࡟࠾࠸࡚ࡣ㸪⩏ṑ⿦╔㸪Ḟᦆ࡞ࡋࡢ㡰࡟ᑐྜṑ࡟ຍࢃࡿညྜຊࡀ᭷ព࡟኱ࡁࡃ࡞ࡗࡓ
㸦p<0.01㸧㸬౛࡜ࡋ࡚㸪ᅗ࡟ୖ㢡୰ษṑ࡟ຍࢃࡿည
ྜຊࢆ♧ࡍ㸬 ௨ୖࡢࡇ࡜࠿ࡽ㸪㐟㞳➃Ḟᦆࡀ㐍⾜ࡍࡿ⛬㸪ညྜ᥋ゐࢆ᭷ࡍࡿᑐྜṑ1ṑ༢఩࡟ຍࢃࡿညྜຊࡣቑ
ຍࡍࡿࡇ࡜ࡀ♧ࡉࢀࡓ㸬ࡲࡓ㸪㐟㞳➃⩏ṑࢆ⿦╔ࡍࡿࡇ࡜࡟ࡼࡾ㸪๓ṑ㒊࡟࠾࠸࡚㸪Ḟᦆṑิᑐྜṑ࡟ຍࢃࡿညྜຊࡀῶᑡࡍࡿࡇ࡜ࡀ♧ࡉࢀࡓ.

    ୖ㢡୰ษṑ࡟ຍࢃࡿညྜຊϫ㸬 ᩥ⊩1) Sarita PT, Kreulen CM, Witter DJ, Van’t Hof M,
Creugers NH. A study on occlusal stability inshortened dental arches. Int J Prosthodont. 2003;
16(4): 375-380.
2) ⿇ᒣள⣖㸬▷⦰ṑิࡢ⿵⥛ฎ⨨ຠᯝ࡟࠾ࡅࡿ
ညྜຊࡢ㔜ᚰ⛣ື ཱྀ⑓ㄅ1996; 63(4): 599-619.

− 134 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1─3─4

ୖ㢡඲㒊ᗋ⩏ṑࡢ⥔ᣢຊ࡜ᗋᚋ⦕ࡢᛂຊ࡜ࡢ㛵ಀ㸫⿕㦂⪅ࡈ࡜ࡢ⥔ᣢຊ ᐃ࡜᭷㝈せ⣲ゎᯒ㸫‫ۑ‬ᑠᕝ㈗ṇ, బ⸨⿱஧, ໭ᕝ ᪼, ୰ὠⓒỤ, 㟷ᰗెዉ, ゅ⏣ᣅဢ, ኱᳃⨾⏤⣖㧗ᯇ┤ஓ᫛࿴኱ᏛṑᏛ㒊㧗㱋⪅ṑ⛉Ꮫㅮᗙ
Relationship between Retention Forces and Stress at Distal Border of Maxillary Complete Denture- Measurement of Retention Forces and Finite Element Analysis in Subjects ‫ۑ‬Ogawa T, Sato Y, Kitagawa N, Nakatsu M, Aoyagi K, Kakuda T, Omori M, Takamatsu N
Department of Geriatric Dentistry㸪Showa University School of DentistryϨ㸬 ┠ⓗ ㉁ࡢ㧗࠸඲㒊ᗋ⩏ṑ἞⒪࡟࠾࠸࡚㸪⩏ṑࡢ⥔ᣢ࣭Ᏻᐃࡣ㔜せ࡛࠶ࡿ㸬඲㒊ᗋ⩏ṑࡢ⥔ᣢຊホ౯࡟㛵ࡍࡿ◊✲ࡣᩘከࡃ⾜ࢃࢀ࡚࠸ࡿࡀ㸪⥔ᣢຊⓎ⏕ࡢ࣓࢝ࢽࢬ࣒ࡣ᫂ࡽ࠿࡟࡞ࡗ࡚࠸࡞࠸㸬ᮏ◊✲ࡣ㸪ୖ㢡඲㒊ᗋ⩏ṑࡢ⥔ᣢຊⓎ⏕࣓࢝ࢽࢬ࣒ࢆゎ᫂ࡍࡿࡇ࡜ࢆ᭱⤊┠ⓗ࡜ࡋ㸪ᐇ㝿ࡢ⿕㦂⪅࡟࠾ࡅࡿ඲㒊ᗋ⩏ṑࡢ⥔ᣢຊ ᐃ⤖ᯝ࡜㸪⿕㦂⪅ࡈ࡜࡟సᡂࡋࡓ᭷㝈せ⣲ࣔࢹࣝ࡟ࡼࡿᛂຊゎᯒ⤖ᯝ࡜ࡢ㛵ಀࢆ᳨ウࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣඛ⾜◊✲1)࡟࠾࠸࡚ୖ㢡⩏ṑ⥔ᣢຊࢆ
ᐃࡋࡓ6ྡ㸦⏨ᛶ3ྡ㸪ዪᛶ3ྡ ᖹᆒᖺ㱋75.5ṓ㸧ࡢୖ㢡↓ṑ㢡⪅࡜ࡋࡓ㸬ඛ⾜◊✲࡛ࡣၚᾮᛶ≧ࡢᙳ㡪ࢆ᤼㝖ࡍࡿࡓࡵ࡟㸪⩏ṑ㸫ᗋୗ⢓⭷㛫ࢆேᕤၚᾮ࡟࡚‶ࡓࡋࡓ≧ែ࡛ ᐃࢆ⾜ࡗࡓ㸬ྛ⿕㦂⪅ࡢࣞࣉࣜ࢝⩏ṑࢆࢫ࢟ࣕࢽࣥࢢࣞࢪࣥ®࡟࡚〇సࡋࡓ㸬ࣞࣉࣜ࢝⩏ṑࢆࢥ࣮ࣥࣅ࣮࣒X⥺CT࡛᧜ᙳᚋ㸪୕ḟඖ᭷㝈せ⣲ゎᯒࢯࣇࢺࢆ⏝࠸㸪ඛ⾜◊✲ࡢᐃ᮲௳ࢆ෌⌧ࡍࡿࡓࡵ㸪ୖ㢡඲㒊ᗋ⩏ṑ㒊ཬࡧᗋୗ⢓⭷㒊㸪⩏ṑࢆそ࠺ࢩ࣮ࢿ㒊ࢆ〇సࡋࡓ㸦ᅗ1㸧㸬⢓⭷㒊ࡣ⩏ṑ⢓⭷㠃࠿ࡽཌࡉ2 mm࡜ࡋ㸪ୖ㠃඲㠃ࢆ᏶඲ᣊ᮰࡜ࡋࡓ㸬ࢩ࣮ࢿ㒊ࡢཌࡉࡣ3 mm࡜タᐃࡋࡓ㸬Ⲵ㔜㒊఩࡜᪉ྥࡣඛ⾜◊✲࡜ྠᵝ࡟㸪#16㸪
26 ୰ᚰ❐ࢆ⤖ࢇࡔ⥺࡜ṇ୰⥺ࡢ஺Ⅼ㸦C㸧࡜⩏ṑᚋ⦕ṇ୰㒊㸦P㸧㸪#26 ୰ᚰ❐㒊㸦MF㸧ࢆୗ᪉࡬≌ᘬ㸪#11㸪21 ษ⦕ࡢṇ୰㒊㸦IM㸧࡜#14 㢋ഃည㢌㒊㸦PC㸧ࢆୖ᪉࡬ຍᅽ࡜ࡋ㸪Ⲵ㔜㔞ࢆ10 N࡜タᐃࡋࡓ㸦ᅗ2㸧㸬ゎᯒ㡿ᇦࡣ㸪⢓⭷㒊ࡢ୧ഃࣁ࣑ࣗ
࣮ࣛࣀࢵࢳࢆそ࠺㛗᪉యࡢ㡿ᇦ࡜ࡋ㸪ᗋୗ⢓⭷ࣔࢹࣝࡢᚋ⦕࠿ࡽ๓᪉᪉ྥ࡟1.5 ੈࡢᖜࢆタᐃࡋࡓ㸬᭱኱୺ᛂຊ࡜ඛ⾜◊✲࡟࡚ ᐃࡋࡓ⩏ṑ⥔ᣢຊ࡜ࡢẚ㍑᳨ウࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ྛ⿕㦂⪅࡟࠾࠸࡚ᗋᚋ⦕ࡢ⢓⭷㸫ᗋቃ⏺㠃࡟Ⓨ⏕ࡋࡓᛂຊศᕸࡣ㢮ఝࡢഴྥࢆ♧ࡋࡓ㸬 ᐃࡉࢀࡓ᭱኱୺ᛂຊࡣP࡟࠾࠸࡚᭱ࡶ㧗࠸್࡜࡞ࡾ㸬ḟ࠸

࡛IM㸪PC㸪C࡛࡯ࡰྠ್ࢆ♧ࡋ㸪MF࡟࠾࠸࡚᭱ࡶ
ప࠸್࡜࡞ࡗࡓ㸦ᅗ3㸧㸬 ⥔ᣢຊࡀ኱ࡁ࠿ࡗࡓィ 㒊఩ࡣⓎ⏕ࡍࡿᛂຊ್
ࡀపࡃ࡞ࡿഴྥ࡟࠶ࡾ㸪⥔ᣢຊࡀᑠࡉ࠿ࡗࡓィ㒊఩ࡣᛂຊ್ࡀ㧗ࡃ࡞ࡿഴྥ࡟࠶ࡗࡓ㸬 ௨ୖࡢ⤖ᯝࡼࡾ㸪ୖ㢡඲㒊ᗋ⩏ṑࡢ⥔ᣢຊ࡜Ⓨ⏕ࡋࡓᛂຊ࡜ࡢ㛵ಀᛶࡀ᫂ࡽ࠿࡟࡞ࡾ㸪୕ḟඖ᭷㝈せ⣲ࣔࢹࣝࢆ⏝࠸ࡓ⥔ᣢຊ᥎ᐃࡀ⾜࠼ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ᅗ 1 ୕ḟඖ᭷㝈せ⣲ࣔࢹࣝᅗ 2 Ⲵ㔜㒊఩

ᅗ 3 ⥔ᣢຊ࡜᭱኱୺ᛂຊࡢ㛵ಀϫ㸬 ᩥ⊩1) ゅ⏣ ᣅဢ, బ⸨ ⿱஧, ໭ᕝ ᪼࡯࠿㸬ୖ㢡඲㒊ᗋ⩏ṑࡢ⥔ᣢຊ ᐃ࡟࠾ࡅࡿ᭱㐺㒊఩࡜Ⲵ㔜᪉ἲ㸬᪥⿵⥛఍ㄅ 6࣭123ᅇ≉ูྕ㸸185(ᢒ㘓)㸪2014− 135 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1─3─5

ຍ⇕㔜ྜ࠾ࡼࡧ㸱Dࣉࣜࣥࢱ࡛〇సࡋࡓ⩏ṑᗋࡢ⢭ᗘ࡜⥔ᣢຊ‫⏣ۑ‬ᆏᙲつ*,****㸪ᯇỌ ᬛ**,****㸪ྂụᓫᚿ***㸪࿴⏣ ೺***㸪஭ᡞᕝ㤶௦***㸪▼ᓮ ᠇***,****㸪ୖ⏣㈗அ***㸪㜿㒊ఙ୍**㸪Ḉ஭ ⸅****ᮾிṑ⛉኱Ꮫࣃ࣮ࢩࣕࣝࢹࣥࢳ࣮ࣕ⿵⥛Ꮫㅮᗙ㸪**ᮾிṑ⛉኱Ꮫゎ๗Ꮫㅮᗙ㸪***ᮾிṑ⛉኱Ꮫ⪁ᖺṑ⛉⿵⥛Ꮫㅮᗙ㸪****ᮾிṑ⛉኱Ꮫཱྀ⭍⛉Ꮫ◊✲ࢭࣥࢱ࣮Accuracy and Retentive Force of Fabricated Denture Base by Heat-curing and 3D printerTasaka A*,****㸪Matsunaga S**,****㸪Koike T***㸪Wada T***㸪Idogawa K***㸪Ishizaki K***,****㸪
Ueda T***㸪Abe S**㸪Sakurai K***
*Department of Removable Partial Prosthodontics㸪**Department of Anatomy㸪***Department ofRemovable Prosthodontics & Gerodontology㸪****Oral Health Science Center, Tokyo Dental CollegeϨ㸬 ┠ⓗ ㏆ᖺ㸪〇㐀ᴗࢆ୰ᚰ࡟་⒪㸪◊✲࠾ࡼࡧᩍ⫱࡞
࡝࡛3Dࣉࣜࣥࢱࡀᬑཬࡋὀ┠ࢆ㞟ࡵ࡚࠸ࡿ㸬ṑ⛉ࡢศ㔝࡟࠾࠸࡚ࡣ㸪࢖ࣥࣉࣛࣥࢺᇙධ⏝ࡢࢫࢸࣥࢺ〇సࡸ㢡ኚᙧ⑕ࡢࣔࢹࣝࢧ࣮ࢪ࢙࣮ࣜ࡟ࡼࡿࢩ
࣑࣮ࣗࣞࢩࣙࣥ࡟ᛂ⏝ࡉࢀ࡚࠸ࡿ1)㸬⿵⥛ศ㔝࡛ࡣ㗪㐀ྍ⬟࡞ࣞࢪࣥࣃࢱ࣮ࣥ࠿ࡽࣇ࣮࣒࣮ࣞ࣡ࢡࡢ
〇స࡟ᛂ⏝ࡉࢀ࡚࠸ࡿࡀ㸪⩏ṑᗋ⏝ᮦᩱ࡜ࡋ࡚ࡣ
ᛂ⏝ࡉࢀ࡚࠸࡞࠸㸬ࡑࡇ࡛ᡃࠎࡣ㸪3Dࣉࣜࣥࢱ࡛
ࡢ⩏ṑᗋ〇సࢆ᝿ᐃࡋ㸪ᚑ᮶ࡢຍ⇕㔜ྜ࡜3Dࣉࣜࣥࢱ࡛〇సࡋࡓᐇ㦂ᗋࡢ⢭ᗘ࠾ࡼࡧ⥔ᣢຊࢆẚ㍑
ࡋࡓ㸬
ϩ㸬 ᪉ἲ
 ୖ㢡↓ṑ㢡ᶍᆺG10FE-402K㸦ࢽࢵࢩࣥ♫〇㸧࠿ࡽ༳㇟᥇ᚓ࡟ࡼࡾసᴗ⏝ᶍᆺࢆ〇సࡋ㸪ࢹࣥࢱࣝ
ࢩࢫࢸ࣒D700-3SP㸦ࣃࢼࢯࢽࢵࢡ࣊ࣝࢫࢣ࢔♫〇㸧ࢆ⏝࠸࡚3Dࢫ࢟ࣕࢽࣥࢢࢆ⾜ࡗࡓ㸬ࡑࡢᚋ㸪సᴗ⏝ᶍᆺୖ࡛ᐇ㦂ᗋࡢ࣡ࢵࢡࢫ࢔ࢵࣉࢆ⾜ࡗࡓࡶࡢࢆ3Dࢫ࢟ࣕࢽࣥࢢࡋࡓ㸬࣡ࢵࢡࢫ࢔ࢵࣉࡋࡓసᴗ⏝ ᶍ ᆺ ࢆ ᇙ ἐ ࡋ 㸪 ຍ ⇕ 㔜 ྜ ࣞ ࢪ ࣥ ACRON No.5
㸦GC♫〇㸧ࢆ⏝࠸࡚㸪ᐇ㦂ᗋࢆ〇సࡋࡓ㸬3Dࣉࣜ
ࣥࢱ࡛ࡢᐇ㦂ᗋࡣObjet260Connex㸦Stratasys♫〇㸧ࢆ ⏝ ࠸ ࡚ 㸪 UV ◳ ໬ ᆺ ࢔ ࢡ ࣜ ࣝ ᶞ ⬡ Vero Clear
㸦Stratasys♫〇㸧࡟࡚〇సࡋࡓ㸬〇సࡋࡓ࠾ࡢ࠾ࡢ
ࡢᐇ㦂ᗋࢆ㓟໬ࢳࢱࣥ࡟࡚ࢥ࣮ࢸ࢕ࣥࢢࡋ㸪ATOS
Core80㸦GOM♫〇㸧࡟࡚3Dࢫ࢟ࣕࢽࣥࢢࢆ⾜ࡗࡓ㸬⢭ᗘ᳨ドࡣຍ⇕㔜ྜ࡟ࡼࡾ〇సࡋࡓᐇ㦂ᗋ࡜3Dࣉ
ࣜࣥࢱ࡛〇సࡋࡓᐇ㦂ᗋࡢࢹ࣮ࢱࡢ㔜ࡡྜࢃࡏ࡜㸪సᴗ⏝ᶍᆺࡢࢹ࣮ࢱ࡟ᑐࡍࡿࡑࢀࡒࢀࡢᐇ㦂ᗋ⢓⭷㠃࠾ࡼࡧ㎶⦕ࡢࢹ࣮ࢱࡢ㔜ࡡྜࢃࡏࢆ3ḟඖࢹ࣮ࢱ᳨ᰝࢯࣇࢺ࢙࢘࢔GOM Inspect㸦GOM♫〇㸧࡟࡚⾜࠸㸪ᙧ≧ᕪศẚ㍑ࢆ⾜ࡗࡓ㸬⥔ᣢຊࡢ ᐃࡣୖ㢡ᶍᆺࡢညྜ㠃ࢆୖ᪉࡟ྥࡅ≌ᘬ⿦⨨࡟ᅛᐃࡋ㸪60%ࢢࣜࢭࣜࣥỈ⁐ᾮ2.1mlࢆேᕤၚᾮ࡜ࡋ࡚ୖ㢡ᶍᆺ࡜ᐇ㦂ᗋࡢ㛫࡟௓ᅾࡉࡏࡓ㸬ࡑࡢᚋ࡟ᐇ㦂ᗋ㔜ᚰ㒊ࡼࡾୖ᪉࡟≌ᘬࡋࡓ㸬≌ᘬ᪉ྥࡣ௬᝿ညྜ
ᖹ㠃࡟ᆶ┤᪉ྥ࡜ࡋ㸪ᐇ㦂ᗋࡀୖ㢡ᶍᆺࡼࡾ㞳⬺ࡋᾋࡁୖࡀࡿࡲ࡛≌ᘬࡋ㸪ࡑࡢ࡜ࡁࡢ≌ᘬຊࡢ᭱኱್ࢆ⥔ᣢຊ࡜つᐃࡋࡓ㸬⤫ィฎ⌮ࡣᐇ㦂ᗋࡢ⥔ᣢຊࡢẚ㍑࡟ࡘ࠸࡚Studentࡢt᳨ᐃࢆ⾜ࡗࡓ㸬᭷ពỈ‽ࡣ0.05࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ຍ⇕㔜ྜ࡟ࡼࡾ〇సࡋࡓᐇ㦂ᗋ࡜3Dࣉࣜࣥࢱ࡛
〇సࡋࡓᐇ㦂ᗋࡢᕪศ್ࡣ̺0.16㹼+0.13mm࡛࠶ࡗࡓ㸬సᴗ⏝ᶍᆺࡢࢹ࣮ࢱ࡟ᑐࡍࡿຍ⇕㔜ྜࣞࢪ࡛ࣥ〇సࡋࡓᐇ㦂ᗋࡢᗋ㎶⦕ࡢ್ࡣ+0.13㹼+0.23mm
࡛㸪ᗋ㎶⦕ࡀᶍᆺ࠿ࡽᾋࡁୖࡀࡿഴྥࡀㄆࡵࡽࢀ
ࡓ㸬ཱྀ⵹୰ኸ࡟࠾࠸࡚ࡣ̺0.07㹼̺0.13mm࡛࠶ࡾ㸪ᶍᆺ࡟㣗࠸㎸ࡴഴྥࡀㄆࡵࡽࢀࡓ㸬୍᪉㸪సᴗ⏝ᶍᆺࡢࢹ࣮ࢱ࡟ᑐࡍࡿ3Dࣉࣜࣥࢱ࡛〇సࡋࡓᐇ㦂ᗋࡢ್ࡣ̺0.08㹼+0.15mm࡛࠶ࡾ㸪ᗋ㎶⦕࠾ࡼࡧ๓
ṑ㒊၁ഃࡢ࢔ࣥࢲ࣮࢝ࢵࢺ࡟ᶍᆺࡀ㣗࠸㎸ࡴഴྥࡀㄆࡵࡽࢀࡓ㸬⥔ᣢຊࡣຍ⇕㔜ྜࡼࡾ3Dࣉࣜࣥࢱ࡛〇సࡋࡓᐇ㦂ᗋࡢ᪉ࡀ኱ࡁࡃ㸪⤫ィᏛⓗ᭷ពᕪࡀㄆࡵࡽࢀࡓ㸬ຍ⇕㔜ྜ࡛〇సࡋࡓᐇ㦂ᗋ࡟࠾࠸࡚ࡣ㸪⩏ṑ㔜ྜᚋࡢయ✚཰⦰㸪ෆ㒊ᛂຊ࠾ࡼࡧṧ␃ᛂຊࡢ㛤ᨺ࡟ࡼࡾ㸪ཱྀ⵹୰ኸ࡟཰⦰ࡀ㞟୰ࡋࡓࡇ࡜࡟ࡼࡾస
ᴗ⏝ᶍᆺ࡜ᗋ㎶⦕࡜ࡢ㛫࡟㛫㝽ࡀ⏕ࡌࡓ࡜⪃࠼ࡽࢀࡓ㸬3Dࣉࣜࣥࢱ࡛〇సࡋࡓᐇ㦂ᗋࡣ๓ṑ㒊࢔ࣥࢲ࣮࢝ࢵࢺ㒊ࡢࢧ࣏࣮ࢺᮦ࡟ࡼࡿ㠃Ⲩࢀࡀᐇ㦂ᗋࡢ⢭ᗘ࡟኱ࡁࡃᙳ㡪ࡋ࡚࠸ࡿࡶࡢࡢ㸪ຍ⇕㔜ྜࡢࡼ࠺࡞཰⦰࡟ࡼࡿኚᙧࡣᑡ࡞࠸࡜⪃࠼ࡽࢀࡓ㸬3D
ࣉࣜࣥࢱ࡛〇సࡍࡿ㝿࡟ࡣ࢔ࣥࢲ࣮࢝ࢵࢺ㒊ࡢฎ⌮࠾ࡼࡧ㐀ᙧ᫬ࡢ᪉ྥࢆ⪃៖ࡍࡿᚲせᛶࡀ♧၀ࡉࢀࡓ㸬௨ୖࡢⅬ࡟ࡘ࠸࡚⪃៖ࡍࢀࡤ㸪⩏ṑᗋࡢ〇
స࡟3Dࣉࣜࣥࢱࢆᛂ⏝ࡍࡿࡇ࡜ࡣྍ⬟࡛࠶ࡿ࡜⪃
࠼ࡽࢀࡓ㸬
ϫ㸬 ᩥ⊩
1) Ⲯ ᮧ Ὀ ἞ 㸬 3D ࣉ ࣜ ࣥ ࢱ ࣮ ࡢ ṑ ⛉ ࡬ ࡢ ᛂ ⏝᪥ṑ་ᖌ఍ㄅ 2013; 66: 473-482.

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日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1─3─6㌾ᛶࣞࢪࣥࢆ⏝࠸ࡓ☢▼ᵓ㐀యࡢ⩏ṑ࡬ࡢᅛᐃ‫ۑ‬ᒸᒣ❶ኴ㑻㸪㕥ᮌᜤ඾㸪᪂ಖ⚽ோ㸪኱ᓥ᫭㸪ᅰ ᬛᏊ㸪኱ஂಖຊᘅ㭯ぢ኱ᏛṑᏛ㒊 ᭷ᗋ⩏ṑ⿵⥛Ꮫㅮᗙ
Fixation of magnet assembly to denture base using alternative resins
Okayama S, Suzuki Y, Shimpo H, Ohshima A, Dan T, Ohkubo C
Department of Removable Prosthodontics, Tsurumi University School of Dental MedicineϨ㸬 ┠ⓗ☢ᛶ࢔ࢱࢵࢳ࣓ࣥࢺࡢ⿦╔࡟ࡣ㏻ᖖ㸪ᖖ 㔜ྜࣞࢪࣥࡀ⏝࠸ࡽࢀ࡚࠸ࡿࡀ㸪ᨭྎṑ࠾ࡼࡧ࣮࢟ࣃ
࣮࿘ᅖࡢ࢔ࣥࢲ࣮࢝ࢵࢺ࡟ࡼࡾ⩏ṑࡀ㞳⬺࡛ࡁ࡞ࡃ࡞ࡿ༴㝤ᛶࡀ࠶ࡿ 1 㸧 㸬ᮏ◊✲࡛ࡣᖖ 㔜ྜࣞࢪࣥࡢ௦᭰ᮦᩱ࡜࡞ࡿヨసࣞࢪࣥࡸヨస☢▼ᵓ㐀యࢆ〇సࡋ㸪Ᏻ඲࡟☢▼ᵓ㐀యࢆಖᣢࡍࡿࡇ࡜ࢆ┠ⓗ࡟ᐇ㦂ⓗ᳨ウࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ ☢▼ᵓ㐀యࡣࣇ࢕ࢪ࣐࢜ࢢࢿࢵࢺ35㸦┤ᚄ3.5mm, ཌࡉ1.3 mm, ྾ᘬຊ㸸⣙5.5 N, Neomax㸧ࢆࢥࣥࢺ࣮ࣟࣝ࡜ࡋ㸪☢▼ᵓ㐀యୖ㠃࡟3✀ࡢ࢔ࣥࢲ࣮
࢝ࢵࢺ㸦0.5 mm, 0.65 mm, 1.0 mm㸧ࢆ௜୚ࡋࡓ☢▼ᵓ㐀యࢆヨసࡋࡓ㸬☢▼ᵓ㐀యಖᣢᮦᩱ࡟ࡣ㌾㉁⿬⿦ᮦ㸦ࢯࣇࢺࣛ
࢖ࢼ࣮㸪GC㸧ࢆ࣓࣮࣮࢝ᣦ♧㏻ࡾࡢᶆ‽⢊ᾮẚࡼࡾ࣏࣐࣮ࣜ㔞ࢆ1.5ಸ࡟ቑຍࡋ౑⏝ࡋࡓ㸬ࣔࣀ࣐࣮ᡂศࡢᯫᶫ๣ࢆㄪᩚࡋࡓヨసࣞࢪࣥ㸪ࣞࢪࣥ⣔௬ᑒᮦ㸦ࢹࣗࣛࢩ࣮ࣝ㸪ࣜࣛ࢖࢔ࣥࢫ㸧㸪ࡲࡓࢥࣥࢺ࣮ࣟࣝ࡜ࡋ࡚ᖖ 㔜ྜࣞࢪࣥ㸦ࣘࢽࣇ࢓ࢫࢺϪ㸪
GC㸧ࢆ౑⏝ࡋࡓ㸬☢▼ᵓ㐀యࡢಖᣢ࡟ࡣ㸪ࡲࡎୗ㒊἞ල࡟☢▼ᵓ㐀యࢆ᥋╔ᚋ㸪☢▼ᵓ㐀యୖ㠃࡟᥋╔ᛶࣞࢪࣥࢭ
࣓ࣥࢺ㸦ࢫ࣮ࣃ࣮࣎ࣥࢻ㸪ࢧ࣓ࣥࢹ࢕࢝ࣝ㸧ࢆሬᕸࡋ㸪⾲㠃ฎ⌮ࢆ᪋ࡋࡓ㸬ࡑࡢᚋ㸪ྛಖᣢᮦᩱࢆ
⏝࠸࡚ୖ㒊἞ල࡟᥋╔ࡋࡓࣁ࢘ࢪࣥࢢ࡜୍య໬ࡉ
ࡏ㸪ᘬᙇヨ㦂ヨᩱ࡜ࡋࡓ㸬ࡲࡓ㸪ୗ㒊἞ල࡟࣮࢟
ࣃ࣮ࢆ᥋╔ࡋ㸪⮫ᗋ᧯స࡜ྠᵝ࡟☢▼ᵓ㐀యࢆ࣮࢟ࣃ࣮ୖ࡟྾╔ࡉࡏ㸪ᘬᙇヨ㦂ヨᩱ࡜ྠᵝ࡟ࣁ࢘ࢪࣥࢢ࡜୍య໬ࡋ㸪⧞ࡾ㏉ࡋ╔⬺ヨ㦂ヨᩱ࡜ࡋࡓ㸬⧞ࡾ㏉ࡋ╔⬺ヨ㦂ᚋ࡟࠾ࡅࡿ⩏ṑᗋෆ࡛ࡢ☢▼ᵓ㐀యࡢಖᣢຊ࠾ࡼࡧ⤒᫬ⓗ࡞྾ᘬຊࡢኚ໬ࢆᘬᙇ
ヨ㦂࡟࡚ ᐃࡋࡓ㸬ᘬᙇヨ㦂࡟ࡣ୓⬟ヨ㦂ᶵ㸦EZS㸪Shimadzu㸧ࢆ౑⏝ࡋ㸪ࢡࣟࢫ࣊ࢵࢻࢫࣆ࣮ࢻ
1.0 mm/min࡟࡚ィ ࡋࡓ㸬⧞ࡾ㏉ࡋ╔⬺ヨ㦂࡟ࡣ⧞ࡾ㏉ࡋ╔⬺ヨ㦂ᶵ㸦JM100-T㸪᪥ᮏ࣓ࢵࢡ㸧ࢆ౑⏝ࡋ㸪ࢡࣟࢫ࣊ࢵࢻࢫࣆ࣮ࢻ950 mm/min࡟࡚
10,000ᅇࡲ࡛≌ᘬ㞳⬺ࢆ⾜ࡗࡓᚋ࡟ᘬᙇヨ㦂ࢆ⾜ࡗࡓ㸬ᚓࡽࢀࡓࢹ࣮ࢱࡣ஧ඖ㓄⨨ศᩓศᯒᚋ㸪

Tukeyࡢከ㔜ẚ㍑᳨ᐃࢆ⾜࠸㸪༴㝤⋡5%࡟࡚⤫ィゎᯒࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1. ಖᣢຊ
10,000ᅇࡢ╔⬺ᚋ㸪࢔ࣥࢲ࣮࢝ࢵࢺࢆ௜୚ࡋࡓ
ࢹࣗࣛࢩ࣮ࣝࡣࣞࢪࣥ࡜ྠᵝ࡟☢▼ᵓ㐀య࡜ಖᣢᮦᩱࡢ㛫࡛⬺㞳ࡍࡿࡇ࡜࡞ࡃ㸪☢▼ᵓ㐀యࡀୗ㒊἞ලࡼࡾศ㞳ࡋࡓࡓࡵ ᐃ୙⬟࡛࠶ࡗࡓ㸬ࡲࡓࢹࣗࣛࢩ࣮ࣝࡣ࢔ࣥࢲ࣮࢝ࢵࢺࡀ↓ࡃ࡚ࡶヨసࣞࢪࣥ ࡟ ẚ ㍑ ࡋ ࡚ 㧗 ࠸ ಖ ᣢ ຊ ࢆ ♧ ࡋ ࡓ 㸦 52.6 N 㸧㸦ᅗ㸧㸬⧞ࡾ㏉ࡋ╔⬺ヨ㦂࡟࠾ࡅࡿ☢▼ᵓ㐀యࡢ⬺㞳ࡣヨసࣞࢪࣥ5ヨᩱ୰㸪1ヨᩱ࡛ㄆࡵࡽࢀࡓࡀ㸪ࡑࡢ௚ࡢ඲࡚ࡢヨᩱ࡟⬺㞳ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬2. ྾ᘬຊ
࢘࢖ࣥࢢࡢ᭷↓࡟ࡼࡿ྾ᘬຊ࡟᭷ពᕪࡣㄆࡵࡽ
ࢀ࡞࠿ࡗࡓ㸦p>0.05㸧㸬ࣞࢪࣥ࡜ࢹࣗࣛࢩ࣮ࣝࡣ
4~5 N࡜୍ᐃࡢ྾ᘬຊࢆ♧ࡋ㸪ヨసࣞࢪࣥࡢึᮇ྾
ᘬຊࡣ௚ࡢᮦᩱ࡜㏆ఝࡋ࡚࠸ࡓࡀ㸪╔⬺1,000ᅇᚋ࡟ࡣᛴ⃭࡟ῶᑡࡋ㸦⣙2.5 N㸧㸪ࡑࡢᚋ2,000ᅇ௨㝆ࡣ୍ᐃࡢ྾ᘬຊࡀ⥔ᣢࡉࢀࡓ㸬ᅗ ⧞ࡾ㏉ࡋ╔⬺ヨ㦂0ᅇ㸪10,000ᅇᚋࡢಖᣢຊϫ㸬 ᩥ⊩1) ▼ୖ཭ᙪ㸬☢ᛶ࢔ࢱࢵࢳ࣓ࣥࢺࡢᒚṔ࡜ᣦ㔪㸬⿵⥛ㄅ 2014(6); 4: 343-350㸬

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第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1─3─7

ࣀ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ⏝⇕ྍረᛶᶞ⬡࡟㛵ࡍࡿᇶ♏
ⓗ◊✲‫ۑ‬Ḉ஭ᩄ⥅㸪௰⏣㇏⏕㸪⬥ ᣅஓ㸪᪂ಖ⚽ோ㸪኱㐨ⱥᚨ㸪బ⸨ⱥኵ㸪኱ஂಖຊᘅ㭯ぢ኱ᏛṑᏛ㒊᭷ᗋ⩏ṑ⿵⥛ᏛㅮᗙCharacteristics of thermoplastic resins for non-metal clasp denture

Sakurai T, Nakata T, Waki T, Shimpo H, Ohmichi H, Sato H, Ohkubo C
Department of Removable Prosthodontics, Tsurumi University School of Dental MedicineϨ㸬 ┠ⓗ 2008 ᖺ࡟࣏ࣜ࢔࣑ࢻ⣔⇕ྍረᛶᶞ⬡ࡀ⩏ṑᗋᮦᩱ࡜ࡋ࡚ㄆྍࡉࢀ࡚࠿ࡽ㸪⩏ṑࡢ⥔ᣢ㒊ࢆ⩏ṑᗋ⏝ࡢᶞ⬡ࢆ⏝࠸࡚〇సࡋࡓࣃ࣮ࢩࣕࣝࢹࣥࢳ࣮ࣕࢆࣀࣥ
࣓ࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ࡜࿧⛠ࡋ㸪ᑂ⨾ᛶ࡟ඃࢀࡿࡇ࡜࠿ࡽ⿵⥛⮫ᗋ࡟࠾࠸࡚ᛴ㏿࡟ᬑཬࡋ࡚࠸ࡿ㸬ࡋ࠿ࡋ㸪タィᣦ㔪ࡸ㐺ᛂ⑕࡞࡝㸪࠸ࡲࡔ୙☜ᐃ࡞ၥ㢟ࡶከ࠸ 1)㸬ࡲࡓ㸪ࣀ ࣥ ࣓ ࢱ ࣝ ࢡ ࣛ ࢫ ࣉ ࢹ ࣥ ࢳ ࣮ࣕ࡟⏝࠸ࡽࢀࡿ⇕ྍረᛶᶞ⬡ࡣ㸪ከᩘࡢ࣓࣮࢝
࣮࠿ࡽከ✀ࡢ〇ရࡀᕷ㈍ࡉࢀ࡚࠸ࡿࡶࡢࡢ㸪ྠ୍᮲௳ୗ࡟࡚⌮ᕤᏛⓗᛶ㉁ࢆẚ㍑᳨ウࡋࡓሗ࿌ࡣ ᑡ ࡞ ࠸ 2) 㸬 ᮏ ◊ ✲ ࡣ ⌧ ᅾ ౑ ⏝ ࡉ ࢀ ࡚ ࠸ ࡿ ࣀ ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ⏝⇕ྍረᛶᶞ⬡ࡢ⌮ᕤᏛⓗᛶ㉁ࢆ᫂ࡽ࠿࡟ࡋ㸪⮫ᗋᛂ⏝࡬ࡢ♧၀ࢆᚓࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚㸪᭤ࡆᙉࡉ㸪╔Ⰽ㸪྾Ỉ㔞࡟㛵ࡋ࡚ᐇ㦂ⓗ᳨ウࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ ࣀ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ⏝⇕ྍረᛶᶞ⬡࡜ࡋ࡚㸪࣏ࣜ࢔࣑ࢻ⣔㸦ࣂ࢖࢜ࣉࣛࢫࢺ:BP㸪ࣂ࢖࢜ࢺ࣮ࣥ:BT㸪ࣇࣞࢵࢡࢫࢫࢱ࣮V:FSV, ࢔ࣝࢸ࢕࣓ࢵࢺ:UM㸪TUM:TM㸧㸪࣏࢚ࣜࢫࢸࣝ⣔㸦࢚ࢫࢸࢩࣙࢵࢺࣈࣛ࢖ࢺ:ESB㸧㸪࣏࣮ࣜ࢝࣎ࢿ࣮ࢺ⣔㸦ࢪ࢙ࢵࢺ࣮࢝࣎-S:JCS㸪ࣞ࢖ࢽࣥࢢN:RN㸧㸪࢔
ࢡࣜࣝ⣔㸦࢔ࢡࣜࢺ࣮ࣥ:ACT㸧ࡢ9✀㢮ࡢᶞ⬡ࢆ⏝࠸ࡓ㸬ࢥࣥࢺ࣮ࣟࣝ࡟ࡣຍ⇕㔜ྜᆺᗋ⏝࢔ࢡࣜࣝࣞࢪࣥ㸦࢔ࢡࣟࣥ:ACR㸧ࢆ౑⏝ࡋࡓ㸬᭤ࡆヨ㦂ࡣISO 1567:2005㸪╔Ⰽヨ㦂ࡣJIS Z8730:2007㸪྾Ỉ㔞ヨ㦂ࡣISO 1567:2005࡟‽ࡌࡓ㸬╔Ⰽヨ㦂࡛ࡣ㸪࣮࢝ࣞ࡜ࢥ࣮ࣄ࣮ࢆ⏝࠸ࡓ㸬ᚓࡽࢀࡓࢹ࣮ࢱࡣ୍
ඖ㓄⨨ศᩓศᯒᚋ㸪Tukeyࡢከ㔜ẚ㍑᳨ᐃࢆ⾜࠸㸪༴㝤⋡5㸣᳨࡛ᐃࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᭤ࡆヨ㦂࡟࠾ࡅࡿᛂຊ㸫ࡦࡎࡳ᭤⥺ࡣACRࡀ⬤ᛶᮦᩱࡢ≉ᚩࢆ♧ࡋࡓࡢ࡟ᑐࡋ㸪඲࡚ࡢ⇕ྍረᛶᶞ⬡ࡣ㠎ᛶᮦᩱࡢ≉ᚩࢆ♧ࡋࡓ㸬᭤ࡆᙉࡉ࡜ᙎᛶ
⋡㸦ᅗ㸧࡟࠾࠸࡚඲࡚ࡢ⇕ྍረᛶᶞ⬡ࡣACR࡜ẚ
㍑ࡋ࡚᭷ព࡟ప࠸್ࢆ♧ࡋ㸦p<0.05㸧㸪୰࡛ࡶBPࡣ᭱ࡶప࠸್ࢆ♧ࡋࡓ㸬ISOつ᱁㸦65MPa㸧࡜ẚ㍑

ࡍࡿ࡜UM࡜TM㸪JCS㸪RNࡢ᭤ࡆᙉࡉࡣᗋ⏝ࣞࢪࣥࡢᇶ‽ࢆ‶ࡓࡋ࡚࠸ࡿࡀ, BPࡣ25.8MPa࡜ᇶ‽ࡢ⣙40%⛬ᗘ࡛࠶ࡗࡓ. ࡲࡓ, ᙎᛶ⋡ࡣ࣏࣮ࣜ࢝࣎ࢿ
࣮ࢺ⣔࡛࠶ࡿJCS㸪RN௨እࡢ⇕ྍረᛶᶞ⬡ࡣ࠸ࡎࢀࡶISOつ᱁㸦2000MPa㸧ࡼࡾప࠸್࡛࠶ࡗࡓ㸬╔Ⰽヨ㦂࡛ࡣ࣮࢝ࣞ࡟࠾࠸࡚㸪BP㸪FSVࡀACR
࡜ẚ㍑ࡋ࡚᭷ព࡟኱ࡁ࡞Ⰽᕪࢆ♧ࡋࡓࡶࡢࡢ㸪௚ࡢ⇕ྍረᛶᶞ⬡ࡣACR࡜ẚ㍑ࡋ࡚ྠ➼ࡢ್ࢆ♧ࡋࡓ㸬ࢥ࣮ࣄ࣮࡟࠾࠸࡚ࡣ㸪BPࡀ௚ࡢᶞ⬡࡜ẚ㍑ࡋ
࡚᭷ព࡟኱ࡁ࠸Ⰽᕪࢆ♧ࡋࡓ㸦p<0.05㸧㸬྾Ỉ㔞
ࡣACR࡜ẚ㍑ࡋ࡚BP㸪ESB㸪JCS㸪RNࡀ᭷ព࡟ᑠ
ࡉ࠸್ࢆ♧ࡋࡓ㸦p<0.05㸧㸬ྛ⇕ྍረᛶᶞ⬡࡟ࡼࡾᛶ㉁ࡣ኱ࡁࡃ␗࡞ࡿࡇ࡜࠿ࡽ㸪ྛᮦᩱ࡜ྜ⮴ࡋࡓタィᣦ㔪㸪ಖ⟶᪉ἲ➼ࢆ᳨ウࡍࡿᚲせᛶࡀ࠶ࡿ࡜⪃࠼ࡽࢀࡓ㸬ྛ✀⇕ྍረᛶᶞ⬡ࡢᙎᛶ⋡ϫ㸬 ᩥ⊩1) ➜ᮌ㈼἞㸪኱ஂಖຊᘅ㸪㇂⏣㒊 ඃ࡯࠿㸬⇕ྍረᛶᶞ⬡ࢆ⏝࠸ࡓ㒊ศᗋ⩏ṑ㸦ࣀ࣓ࣥࢱࣝ
ࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ㸧ࡢ⮫ᗋᛂ⏝㸬⿵⥛ㄅ
5:387-408, 2013.
2) Takabayashi Y. Characteristics of denture
thermoplastic resins for non-metal clasp dentures.
Dent Mater J 29:353-361, 2010.

− 138 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1─3─8ࣀ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ࡟⏝࠸ࡿᗋ⏝ᮦᩱ࠾ࡼࡧࢡࣛ
ࢫࣉࢹࢨ࢖ࣥࡢ᳨ウ‫ۑ‬ᒾ⏣ዲᘯ㸪ᕝⰋ⨾బ㞝㸪ᒾᓮṇᩄ㸪ᮏ⏣ᐇຍ㸪ྜྷᮧ୓⏤Ꮚ㸪ὸᕝ㱟ே㸪㕥ᮌᾈྖ㸪ᑠぢᒣ㐨㸪ෆ⏣൉୍㑻*㸪すᒣ඾ᏹ*᪥ᮏ኱ᏛᯇᡞṑᏛ㒊㢡ཱྀ⭍ᶵ⬟἞⒪Ꮫㅮᗙ㸪 *᪥ᮏ኱ᏛᯇᡞṑᏛ㒊ṑ⛉⏕యᮦᩱᏛㅮᗙ
Clasp designs for non-metal clasp denture materials
Iwata Y, Kawara M, Iwasaki M, Honda M, Yoshimura M, Asakawa R, Suzuki H, Uchida R*, Nishiyama N*
Department of Oral Function and Rehabilitation, Nihon University School of Dentistry at Matsudo*Department of Dental Biomaterials, Nihon University School of Dentistry at MatsudoϨ㸬 ┠ⓗ ṑ⛉⮫ᗋ࡟࠾࠸࡚ࣀ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳࣕ
࣮ࡀᗈࡃ⮫ᗋᛂ⏝ࡉࢀࡿࡼ࠺࡟࡞ࡗࡓ{Ϳ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪ࣞࢪࣥࢡࣛࢫࣉࡢࢹࢨ࢖ࣥ࡟ࡘ࠸࡚ࡣ᫂
☜࡞ᣦ㔪ࡣ࡞࠸㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪0.5ੈ࢔ࣥࢲ࣮
࢝ࢵࢺ࡟⇕ྍረᛶᑕฟᡂᙧᆺ⩏ṑᗋ⏝ࣞࢪࣥ࡜ྠ
ᵝ࡞Ⲵ㔜㔞࡛ᤄධ࣭᧔ཤࡀྍ⬟࡞PMMA⣔⩏ṑᗋ⏝ࣞࢪࣥࡀ౑⏝ྍ⬟࠿ྰ࠿ࢆ᳨ウࡋ㸪ࡑࡢࢹࢨ࢖
ࣥࢆ☜❧ࡍࡿࡇ࡜࡛࠶ࡿ㸬௨ୖࡼࡾ㸪PMMA⣔⩏ṑᗋ⏝ࣞࢪࣥ࡟࠾࠸࡚ࡣ㸪PIࡀ⇕ྍረᛶᑕฟᡂᙧᆺ⩏ṑᗋ⏝ࣞࢪࣥ࡜ྠ⛬ᗘࡢⲴ㔜㔞࡟࡚0.5ੈ࢔ࣥࢲ࣮࢝ࢵࢺ࡟ᤄධ࣭᧔ཤࢆ
ྍ⬟࡜ࡍࡿ஦ࡀ♧၀ࡉࢀࡓ㸬ࡇࡢࡇ࡜ࡣ㸪ᚑ᮶ࡼࡾ౑⏝ࡉࢀ࡚࠸ࡿPMMA⣔⩏ṑᗋ⏝ࣞࢪࣥ࡟࠾࠸࡚ࡶ㸪ᮦᩱࢆ㑅ᢥࡍࡿࡇ࡜
࡟ࡼࡾࣀ࣓ࣥࢱࣝࢡࣛࢫࣉࢹࣥࢳ࣮ࣕ࡬ࡢᛂ⏝ࡢྍ⬟ᛶࢆ♧ࡍ㸬ࡲࡓPI࡟࠾࠸࡚ࡣ㸪ࢡࣛࢫࣉࢹࢨ
࢖ࣥࡣLTF࠾ࡼࡧESB࡜ྠᵝ࡛ࡼ࠸ࡇ࡜ࡀ♧၀ࡉࢀ
ࡓ㸬

ϩ㸬 ᪉ἲ
 ᮏ◊✲࡟ࡣ㸪ࣂࣝࣉࣛࢫࢺ㸦ࣘࢽࣂࣝ㸪ᮾி㸪᪥ᮏ㸹VAL㸧㸪ࣝࢩࢺ࣮ࣥFRS㸦ࢹࣥࢶࣉࣛ࢖㸪࣌ࣥࢩࣝࣂࢽ࢔㸪࢔࣓ࣜ࢝ྜ⾗ᅜ㸹LTF㸧㸪࢚ࢫࢸࢩࣙࢵࢺࣈࣛ࢖ࢺ㸦࢔࢖࢟ࣕࢫࢺ㸪ி㒔㸪᪥ᮏ㸹ESB㸪ࣞ࢖ࢽࣥࢢᶞ⬡N㸦ᮾఙὒ⾜㸪᪂₲㸪᪥ᮏ㸹REN㸧㸪࢔ࢡࣜ㸸ࢺ࣮ࣥ㸦ࣁ࢖ࢹࣥࢱࣝࢪࣕ
ࣃࣥ㸪኱㜰㸪᪥ᮏ㸹ACT㸧ࡢ5ࡘࡢ⇕ྍረᛶᑕฟᡂ
ᙧᆺ⩏ṑᗋ⏝ࣞࢪࣥࢆ⏝࠸ࡓ㸬PMMA⣔⩏ṑᗋ⏝ࣞࢪࣥࡣ㸪ຍ⇕㔜ྜᆺ࢔ࢡࣟࣥ㸦GC㸪ᮾி㸪᪥ᮏ㸹 AC㸪㸧㸪ࣉࣟ࢖ࣥࣃࢡࢺ㸦GC㸪ᮾி㸪᪥ᮏ㸹PI㸧࠾ࡼࡧᖖ 㔜ྜᆺࣉࣟ࢟ࣕࢫࢺDSP㸦GC㸪ᮾி㸪᪥ᮏ㸹PC㸧ࢆ⏝࠸ࡓ㸬ヨᩱస〇ࡣ࣓࣮࣮࢝
ᣦ♧࡟ᚑ࠸㸪㛗ࡉ50ੈ㸪ᖜ7ੈ㸪ཌࡉ1.5ੈ࡟࡚඲ヨᩱྛ5ಶࡎࡘస〇ࢆ⾜ࡗࡓ㸬ヨᩱ◊☻ࡣ㸪600␒ࡢ⪏Ỉ⣬ࡲ࡛⾜ࡗࡓ㸬∦ᣢࡕᱱヨ㦂ࡣ㸪Ⲵ㔜ヨ㦂ჾ㸦TG-5kN㸪࣑ࢿ࣋࢔㸪㛗㔝㸪᪥ᮏ㸧ࢆ⏝࠸࡚Ⲵ
㔜Ⅼ㊥㞳7.5ੈ㸪ࢡࣟࢫ࣊ࢵࢻࢫࣆ࣮ࢻẖศ2ੈ࡟
࡚0.5ੈኚᙧ᫬ࡢⲴ㔜㔞ࢆ ᐃࡋࡓ㸬⤫ィศᯒࡣ୍ඖ㓄⨨ศᩓศᯒࢆ⾜࠸㸪ከ㔜ẚ㍑ศ
ᯒࡣTukeyἲࢆ⏝࠸࡚᭷ពỈ‽Ș=0.05࡟࡚⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
 PMMA⣔⩏ṑᗋ⏝ࣞࢪࣥ࡟ࡘ࠸࡚ࡳࡿ࡜㸪AC࡜
VAL㸪LTF㸪ESB㸪ACT࡜ࡢ㛫㸪࠾ࡼࡧPC࡜VAL㸪
LTF 㸪 ESB ࡜ ࡢ 㛫 ࡟ ᭷ ព ࡞ ᕪ ࡀ ࡳ ࡽ ࢀ ࡓ 㸦 P <0.05㸧㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪PI࡜LTF㸪ESB㸪REN㸪
ACT࡜ࡢ㛫࡟ࡣ᭷ព࡞ᕪࡣࡳࡽࢀ࡞࠿ࡗࡓ㸦P >0.05㸧㸦ᅗ㸪⾲㸧㸬

0.016
0.01100.014Ⲵ㔜㔞 (KN)

0.012
0.01
0.0068

0.008
0.006

0.01140.01080.00920.00810.00780.0050

0.004
0.002
0
VAL

LTF

ESB

REN

ACT

AC

PI

PC

ᅗ㸬 0.5 ੈኚᙧ᫬ࡢⲴ㔜㔞⾲㸬 0.5 ੈኚᙧ᫬ࡢⲴ㔜㔞ࡢẚ㍑
㼂㻭㻸
㼂㻭㻸
㻸㼀㻲
㻱㻿㻮
㻾㻱㻺
䠆
㻭㻯㼀
㻭㻯
䠆
㻼㻵
䠆
㻼㻯
䠆
㻖㻌㻼㻌㻨㻌㻜㻚㻜㻡

㻸㼀㻲

㻱㻿㻮

㻾㻱㻺

㻭㻯㼀

㻭㻯

㻼㻵

㻼㻯

䠆
䠆

䠆

䠆

䠆

䠆

ϫ㸬 ᩥ⊩
1) ➜ᮌ㈼἞㸪኱ஂಖຊᘅ㸪㇂⏣㒊ඃ࡯࠿㸬⇕ྍረᛶᶞ⬡ࢆ⏝࠸ࡓ㒊ศᗋ⩏ṑ㸦ࣀ࣓ࣥࢱࣝࢡ
ࣛࢫࣉࢹࣥࢳ࣮ࣕ㸧ࡢ⮫ᗋᛂ⏝㸬᪥⿵⥛఍ㄅ
2013;5 :4:387-408− 139 −

第1日

日補綴会誌

第 3 会場

7･124 回特別号，2015

一般口演発表1─3─9࢚ࣥࢻ࢜ࣈࣛ࢖ࣇ࡟࠾ࡅࡿ⿵⥛ṑ⛉ࡢᙺ๭㸫⦆࿴ࢣ࢔⑓Ჷ┳ㆤᖌ࡬ࡢ㉁ၥ⚊ㄪᰝࡼࡾ㸫‫ྥۑ‬ᒣ ோᶓ὾ᕷ❧ࡳ࡞࡜㉥༑Ꮠ⑓㝔ṑ⛉ཱྀ⭍እ⛉A Role of Prosthodontics in the End-of-Life Care
-Questionairre Survey Against the Nusrses working in Palliative Care UnitMukohyama H
Department of Oral Surgery, Yokohama City Minato Red Cross Hospital஦ෆᐜࡢᨵၿ152ྡ㸪㣗஦ᦤྲྀ㔞ࡢᨵၿ214ྡ㸪ᝈ⪅ࡢែᗘࡢኚ໬126ྡ㸪ᝈ⪅ᐙ᪘ࡢែᗘࡢኚ໬73ྡ㸪ࡑࡢ௚59ྡ࡛࠶ࡗࡓ㸬ཱྀ⭍ࢣ࢔࡟ࡘ࠸࡚ࡣ497ேࡀᚲせ࡜⪃࠼࡚࠸ࡓ㸬ཱྀ⭍ࢣ࢔࡟ᮇᚅࡍࡿࡶࡢࡣୖ఩࠿ࡽ㡰࡟㸪ཱྀ⮯㸪ಖΎ㸪∝ᛌឤ㸪⤯ᑐ㸪ឤᰁ㸪⫵⅖ண㜵࡛࠶ࡗࡓ㸬
484ேࡀཱྀ⭍ࢣ࢔࡟ᅔࡗࡓ࡜ࡋ㸪ࡑࡢෆᐜࡣ⾲2ࡢࡼ࠺࡛࠶ࡗࡓ㸬Ϩ㸬 ┠ⓗ ⤊ᮎᮇ་⒪࠾ࡅࡿṑ⛉௓ධࡢ㔜せᛶࡣሗ࿌ࡉࢀ
1,2)࡚࠸ࡿࡀ 㸪⦆࿴ࢣ࢔⑓Ჷ┳ㆤᖌࡢཱྀ⭍ࢺࣛࣈࣝ࡟ᑐࡍࡿᑐᛂ≧ἣ࡟ࡘ࠸࡚ሗ࿌ࡉࢀࡓࡶࡢࡣᑡ࡞
࠸⦆࿴ࢣ࢔⑓Ჷ┳ㆤᖌ࡟࢔ࣥࢣ࣮ࢺㄪᰝࢆ⾜࠸㸪௒ᚋࡢ⦆࿴ࢣ࢔⑓Ჷ࡟࠾ࡅࡿṑ⛉௓ධࡢ࠶ࡾ᪉ࢆ᳨ウࡍࡿࡓࡵ࡟ᮏ◊✲ࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ㛵ᮾࡢ48⑓㝔913ᗋ㸦࢔ࣥࢣ࣮ࢺᐇ᪋᫬ࡢ඲ᅜ⦆
࿴ࢣ࢔⑓㝔209⑓㝔4173ᗋ୰㸧ࡢ⦆࿴ࢣ࢔⑓Ჷ࡟໅
ົࡍࡿ┳ㆤᖌࢆᑐ㇟࡟┳ㆤ㒊㛗࠶࡚࡟㸪ᮏ◊✲ࡢ
㊃᪨ࢆグ㍕ࡋࡓᡭ⣬࡜࡜ࡶ࡟ṑ⛉἞⒪࡟㛵ࡍࡿ࢔ࣥࢣ࣮ࢺࢆ㒑㏦ࡋ㸪48⑓㝔ࡢ࠺ࡕ36⑓㝔501ேࡢ┳ㆤᖌࡼࡾᅇ⟅ࡀᚓࡽࢀࡓ㸬࡞࠾㸪࢔ࣥࢣ࣮ࢺࡣ↓グྡ࡛⾜࠸㸪ᅇ⟅ࡉࢀࡓ࢔ࣥࢣ࣮ࢺ⏝⣬ࡣಶேูࡢᑒ⟄࡟ᑒࢆࡋ࡚ᅇ཰ࡋࣉࣛ࢖ࣂࢩ࣮ࢆಖㆤࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹṑ⛉࡟἞⒪ࢆ౫㢗ࡋࡓࡇ࡜ࡀ࠶ࡾࡲࡍ࠿㸽ࡢ㉁ၥ࡟ࡘ࠸࡚ࡣ501ே୰461ே࡛ṑ⛉἞⒪౫㢗ࡢ⤒㦂ࡀ࠶ࡗࡓ㸬ṑ⛉࡟౫㢗ࡋࡓෆヂࡣ⾲1ࡢࡼ࠺࡛࠶ࡗ
⾲ṑ⛉ຍ⒪౫㢗ෆヂෆヂ㸦」ᩘ㑅ᢥྍ⬟㸧⩏ṑ࡟㛵ࡍࡿࡶࡢ

ᅇ⟅ᩘ ືᦂṑ 

⢓⭷ࠊṑ⫗ࡢ␗ᖖ㸦⑊③ࠊ⭘⬽ࠊฟ⾑࡞࡝㸧 

࠺ṑ㸦⹸ṑ㸧 ࡑࡢ௚⾲ ཱྀ⭍ࢣ࢔࡟ᅔࡗࡓࡇ࡜
ෆヂ㸦」ᩘ㑅ᢥྍ⬟㸧
ởᰁ 

ᅇ⟅ᩘ

㸣

 

ཱྀ⭍ဗ㢌㒊ࡢࡀࢇ࡛ࢣ࢔ࡀᅔ㞴  

⯉ⱏ 

㛤ཱྀᅔ㞴  ஝⇱  ཱྀ⮯  

ࢣ࢔ࡢຠᯝࡀ࠶ࡀࡽ࡞࠸ ᝈ⪅ࡢ༠ຊࡀᚓࡽࢀ࡞࠸ 

ࡑࡢ௚            ཱྀ⭍ࢣ࢔ࢆṑ⛉࡟౫㢗ࡋࡓࡇ࡜ࡀ࠶ࡿ242ே㸪࡞࠸254ே࡛࠶ࡗࡓ㸬౫㢗ࡋࡓ⌮⏤ࡣ㸪ởᰁ㸪ཱྀ⭍ဗ㢌㒊ࡢࡀࢇ㸪⯉ⱏࡀከ࠿ࡗࡓ㸬࠸࠸࠼࡜ᅇ⟅ࡋࡓ⌮⏤ࡣࢱ࢖࣑ࣥࢢࡀࢃ࠿ࡽ࡞࠸㸪㝔ෆ㸪ࡶࡋࡃࡣ㏆ࡃ࡟ṑ⛉ࡀ࡞࠸࡜࠸࠺ࡶࡢ࡛࠶ࡗࡓ㸬௨ୖࡼࡾ࢚ࣥࢻ࢜ࣈࣛ࢖ࣇࢣ࢔࡟࠾࠸࡚ணᚋࡣ
㝈ࡽࢀ࡚࠸ࡿࡀṑ⛉ࡀ࡛ࡁࡿᨭᣢ⒪ἲ࡜ࡋ࡚⩏ṑ
἞⒪ࢆྵࡴṑ⛉἞⒪ࡸཱྀ⭍ࢣ࢔࡟ᑐᛂࡋ࡚࠸ࡃࡇ
࡜ࡣ༑ศព⩏ࡀ࠶ࡿ࡜⪃࠼ࡽ࠼ࡓ㸬ࡓ㸬ṑ⛉἞⒪ࢆ౫㢗ࡋࡓࡇ࡜ࡀ࡞࠸࡜ᅇ⟅ࡋࡓேࡢ⌮⏤ࡣ㸦」ᩘᅇ⟅ྍ㸧ࡣ㸪ᚲせᛶࢆឤࡌ࡞࠿ࡗ
ࡓ10ྡ㸪౫㢗ࡍࡿࢱ࢖࣑ࣥࢢࡀࢃ࠿ࡽ࡞࠸15ྡ㸪་ᖌ࡬ࡢ౫㢗ࡀ㠃ಽ1ྡ㸪ᝈ⪅ࡢணᚋࡀ▷࠸7ྡ㸪ࡍࡄ࡟ཷデ࡛ࡁࡿṑ⛉ࡀࡲࢃࡾ࡟࡞࠸8ྡ㸪ᝈ⪅ࡶࡋࡃࡣᐙ᪘ࡀᕼᮃࡋ࡞࠸7ྡ㸪ࡑࡢ௚10ྡ࡛࠶ࡗࡓ㸬ṑ⛉࡟ࡼࡿ἞⒪ࡢ௓ධࡀ࠶ࡗࡓሙྜ㸪ṑ⛉἞⒪࡟
ࡼࡗ࡚ఱࡽ࠿ࡢᨵၿࡣ࠶ࡾࡲࡋࡓ࠿࡜ࡢၥ࠸࡟ࡣ
ࡣ࠸373ྡ㸪࠸࠸࠼27ྡ㸪ࢃ࠿ࡽ࡞࠸57ྡ㸪↓ᅇ⟅44ྡ࡛࠶ࡗࡓ㸬ࡲࡓᨵၿࡀ࠶ࡗࡓⅬ࡟ࡘ࠸࡚ࡣ㣗ϫ㸬 ᩥ⊩1) Paunovich ED, Aubertin MA, Saunders MJ,
Prange M., The role of dentistry in palliative careof the head and neck cancer patient. Tex Dent J.
2000; 117: 36-45.
2) Schimmel M, Schoeni P, Zulian GB, Müller F.,
Utilisation of dental services in a university
hospital palliative and long-term care unit in
Geneva. Gerodontology. 2008; 25: 107-112.

− 140 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 10᭱኱㛤ཱྀ㔞࡜᭱኱ညྜຊ࡜ࡢ㛵㐃࡟ࡘ࠸࡚㸫ṇᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅࡜ࡢẚ㍑㸫

‫ۑ‬ᒣᮏྖᑗ㸪୰ᮧ೺ኴ㑻㸪෠⏣┿୍ 㸪⚟ἑ⿱ᇶ 㸪㧗⏣๛ 㸪୚㑣ᕊຌᚿ 㸪஭ᅵ᱇௓ 㸪⁁஭ඃ⏕ 㸪ኴ⏣ᚿ㯞 㸪Ἔ㇂ᚁᙪ 㸪బ఑ගつ 㸪ᑠ㔝ἑ⚽ᶞᮾᾏᨭ㒊㸪 㛵すᨭ㒊㸪**ᰴᘧ఍♫ࢪ࣮ࢩ࣮
Relation between Range of Jaw Motion and Occlusal Force- Compared Normal Subjects with Stomatognathic Dysfunction PatientsYamamoto M, Nakamura K, Tomita S*, Fukuzawa H*, Takada T*, Yonamine A*, Ido K*, Mizoi M*, Ota S, *Yutani M*, Saeki M*, Onozawa H**
Tokai Branch, *Kansai Branch, **GC Co.

Ϩ㸬 ┠ⓗ ࢃࢀࢃࢀࡣࡇࢀࡲ࡛᪥ᮏ⿵⥛ṑ⛉Ꮫ఍Ꮫ⾡኱఍࡟࠾࠸࡚೺ᖖ᭷ṑ㢡⪅࠾ࡼࡧ㢡ᶵ⬟㞀ᐖ⪅࡟࠾ࡅࡿ㛤ཱྀ㔞࡜ညྜຊࡢ㛵ಀ࡟ࡘ࠸᳨࡚ウࢆ⾜࠸㸪᭱኱㛤ཱྀ㔞ࡢᇶ‽್ࢆ᫂☜࡟ࡋ㸪㛤ཱྀ㔞࡜ညྜຊ࡜
ࡢ㛫࡟┦㛵ࡀ࡞࠸ࡇ࡜ࢆሗ࿌ࡋ࡚ࡁࡓ1,2)㸬
 ࡑࡇ࡛௒ᅇࡣ೺ᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅ࢆᑐ㇟࡜ࡋ㸪᭱኱㛤ཱྀ㔞࡜᭱኱ညྜຊ࡟ࡘ࠸࡚୧⪅ࡢẚ㍑ࢆ⾜࠺ࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬㢡ᶵ⬟㞀ᐖ⪅࡜ࡢ㛫࡟᭷ពᕪ㸦<0.01㸧ࢆㄆࡵࡓ㸬ࡲࡓ೺ᖖ᭷ṑ㢡⪅࡛ᛶᕪࢆㄆࡵࡓ
㸦<0.001㸧
㸬
 3. ညྜຊ⾲♧㠃✚㸦OA㸧ࡣ⏨ዪ࡜ࡶ࡟೺ᖖ᭷
ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅࡜ࡢ㛫࡟᭷ពᕪ㸦⏨ᛶ㸸<0.01㸪ዪᛶ㸸<0.01㸧ࢆㄆࡵࡓ㸬ࡲࡓ೺ᖖ᭷ṑ㢡⪅࡛ᛶᕪࢆㄆࡵࡓ㸦<0.001㸧㸬 ௨ୖࡢࡇ࡜࠿ࡽ㸪㢡ᶵ⬟㞀ᐖ⪅ࡣ೺ᖖ᭷ṑ㢡⪅ࡼࡾࡶ᭱኱㛤ཱྀ㔞ࡀᑡ࡞࠸ࡇ࡜ࡀࢃ࠿ࡗࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣᐇ㦂࡟ྠពࡀᚓࡽࢀࡓ೺ᖖ᭷ṑ㢡⪅571
ྡ㸦⏨ᛶ228ྡ㸪16ࠥ83ṓ㸸ᖹᆒ43.0ṓ㸪ዪᛶ343
ྡ㸪15ࠥ79ṓ㸸ᖹᆒ40.8ṓ㸧㸪㢡ᶵ⬟㞀ᐖ⪅101ྡ㸦⏨ᛶ21ྡ㸪20ࠥ73ṓ㸸ᖹᆒ43.5ṓ㸪ዪᛶ80ྡ㸪
16ࠥ69ṓ㸸ᖹᆒ36.4ṓ㸧࡛࠶ࡿ㸬 ᭱኱㛤ཱྀ㔞ࡢ ᐃࡣ㸪஦๓࡟᭱኱㛤ཱྀ㐠ືࢆ༑ศ࡟⾜ࢃࡏࡓᚋ㸪ࣀࢠࢫ㸦ࢹࣥࢱࣝ࢟ࣕࣜࣃࢫ㸪
YMD㸪ᮾி㸪᪥ᮏ㸧ࢆ⏝࠸㸪᭱኱㛤ཱྀ᫬ࡢୖୗ㢡୰ษṑ㏆ᚰ㝮ゅ୰Ⅼ㛫ࡢ㊥㞳ࢆィ ࡋࡓ㸬 ᭱኱ညྜຊࡣࢹࣥࢱࣝࣉࣞࢫࢣ࣮ࣝ㸦50H࣭ࢱ
࢖ࣉR࣭ࢧ࢖ࢬL㸪ࢪ࣮ࢩ࣮㸪ᮾி㸪᪥ᮏ㸧ࢆ୰ᮧࡢ᪉ἲ࡟‽ࡌ࡚᥇ᚓࡋ㸪ညྜຊ ᐃࢩࢫࢸ࣒㸦DePROS㸦ࢹࣥࢱࣝࣉࣞࢫࢣ࣮ࣝ࢜ࢡ࣮ࣝࢨ࣮ࢩ
ࢫࢸ࣒㸧㸪ࢪ࣮ࢩ࣮㸪ᮾி㸪᪥ᮏ㸧ࡢညྜຊ ᐃ⿦⨨㸦࢜ࢡ࣮ࣝࢨ࣮709㸪ࢪ࣮ࢩ࣮㸪ᮾி㸪᪥ᮏ㸧࡟࡚ညྜຊ㸪ညྜຊ⾲♧㠃✚࠾ࡼࡧᖹᆒᅽࢆ ᐃࡋࡓ㸬 ⤫ィゎᯒࡣ೺ᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅࡜ࡢẚ
㍑㸪ࡑࢀࡒࢀᛶᕪ࡟ࡘ࠸࡚Mann-Whitney᳨ᐃ࡛⾜ࡗࡓ㸬೺ᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅࡜ࡢẚ㍑

Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᭱኱㛤ཱྀ㔞࡜ညྜຊ࡟ࡘ࠸࡚೺ᖖ᭷ṑ㢡⪅㸦NA㸧࡜㢡ᶵ⬟㞀ᐖ⪅㸦UA㸧ࢆẚ㍑ࡋࡓ⤖ᯝ㸦⾲㸧㸪
 1. ᭱኱㛤ཱྀ㔞㸦MO㸧ࡣ⏨ዪ࡜ࡶ࡟೺ᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟㞀ᐖ⪅࡜ࡢ㛫࡟᭷ពᕪ㸦<0.001㸧
ࢆㄆࡵࡓ㸬ࡲࡓ೺ᖖ᭷ṑ㢡⪅࡛ᛶᕪࢆㄆࡵ
ࡓ㸦<0.001㸧
㸬 2. ᭱኱ညྜຊ㸦MF㸧ࡣ⏨ᛶ࡛೺ᖖ᭷ṑ㢡⪅࡜

NA
UA

NA
UA

NA
UA

MO (mm)male
50.2 (SD 6.9)
female45.9 (SD 5.8)
male
42.5 (SD 10.4)
female42.4 (SD 7.8)
MF (N)
male
707.4 (SD 290.8)
female518.1 (SD 263.5)
male
511.4 (SD 315.7)
female450.1 (SD 219.5)
OA (mm2)
male
18.1 (SD 7.9)
female12.6 (SD 6.0)
male
13.0 (SD 7.4)
female10.9 (SD 5.2)

ϫ㸬 ᩥ⊩1) ෠⏣┿୍㸪୰ᮧ೺ኴ㑻㸪ᒣᮏྖᑗ㸪⚟ἑ⿱ᇶ㸪஭ᅵ᱇௓㸪㧗⏣๛࡯࠿㸬᭱኱㛤ཱྀ㔞࡜᭱኱ညྜຊࡢ㛵ಀ࡟ࡘ࠸࡚㸫೺ᖖ᭷ṑ㢡⪅࡟ࡼࡿ᳨ウ㸫㸬᪥⿵⥛఍ㄅ 2013㸹5࣭122ᅇ≉ูྕ㸸
292㸬2) ෠⏣┿୍㸪୰ᮧ೺ኴ㑻㸪ᒣᮏྖᑗ㸪⚟ἑ⿱ᇶ㸪㧗⏣๛㸪୚㑣ᕊຌᚿ࡯࠿㸬㢡ᶵ⬟㞀ᐖ⪅ࡢ㛤ཱྀ㔞࡜ညྜຊࡢ㛵ಀ㸬᪥⿵⥛఍ㄅ 2014㸹
6࣭123ᅇ≉ูྕ㸸239㸬

− 141 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 11

ARCUSdigmaII࡟ࡼࡿ࿪ᄮ⤊ᮎ఩ࡢホ౯‫ۑ‬୰ᮧ೺ኴ㑻㸪ᒣᮏྖᑗ㸪㏆⸨ᗣྐ㸪ᯘ⿱ஂ㸪⣽ᕝ⛱᫭*㸪H. W. Lang*ᮾᾏᨭ㒊㸪*࢝࣎ࢹࣥࢱࣝࢩࢫࢸ࣒ࢬࢪࣕࣃࣥ㸦ᰴ㸧
Evaluate of Masticatory Terminal Position using ARCUSdigmaII
Nakamura K, Yamamoto M, Kondo Y. Hayashi. H, Hosokawa T*, Lang HW*Tokai Branch, *KaVo Dental Systems Japan Co., Ltd.

Ϩ㸬 ┠ⓗ ࢃࢀࢃࢀࡣࡇࢀࡲ࡛ග఩⨨ ᐃ᪉ᘧ6⮬⏤ᗘ㢡㐠ື ᐃ⿦⨨㸦MM-J2㸪ᯇ㢼㸪ி㒔㸪᪥ᮏ㸧࡜࿪ᄮ⤊ᮎ఩ศᯒࣉࣟࢢ࣒ࣛࢆ⏝࠸࡚㸪㣗ရࡢ࠿ࡓࡉࡀ
␗࡞ࡗ࡚ࡶ࿪ᄮ㐠ື㊰ࡢ⤊ᮎ఩ࡀࡍ࡭࡚࿪ᄮ⤊ᮎ఩࡟㐩ࡍࡿࡇ࡜㸪࿪ᄮ㞀ᐖࢆ᭷ࡍࡿ⿕㦂⪅ࡣ㸪㣗ရࡢ࠿ࡓࡉ࡟࠿࠿ࢃࡽࡎ࿪ᄮ⤊ᮎ఩࡜ည㢌ᔐྜ఩ࡀ୍⮴ࡋ࡞࠸ࡇ࡜ࢆሗ࿌ࡋࡓ1)㸬
 ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪ࢹࢪࢱࣝᘧ㢡㐠ືィ ⿦⨨
㸦ARCUSdigmaϩ㸪࢝࣎ࢹࣥࢱࣝࢩࢫࢸ࣒ࢬࢪࣕ
ࣃࣥ㸪ᮾி㸪᪥ᮏ㸧ࢆ⏝࠸࡚㣗ရᛶ≧ࡢ㐪࠸ࡀ࿪ᄮ⤊ᮎ఩࡟࠾ࡼࡰࡍᙳ㡪ࢆ᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜
ࡋࡓ㸬
ϩ㸬 ᪉ἲ
 ⿕㦂⪅ࡢ㑅ᐃ࡟ࡣ࿪ᄮ㞀ᐖࡢ᭷↓ࢆVAS࠾ࡼࡧ࿪ᄮ㞴᫆ᗘ᳨ᰝ࠿ࡽุᐃࡋࡓ㸬࿪ᄮ㞀ᐖࢆ᭷ࡉ࡞
࠸࡜デ᩿ࡋࡓ⿕㦂⪅ࡣ⏨ᛶ1ྡ㸦38ṓ㸧㸪࿪ᄮ㞀ᐖࢆ᭷ࡍࡿ⿕㦂⪅ࡣ⏨ᛶ1ྡ㸦40ṓ㸧࡛࠶ࡿ㸬୧⪅࡜ࡶ࡟ᐇ㦂ࡢྠពࡀᚓࡽࢀ࡚࠸ࡿ㸬 ⿕㦂㣗ရࡣ࿪ᄮ⬟ຊ᳨ᰝ⾲2)࠿ࡽ࠿ࡓࡉࢆ5ẁ㝵࡟༊ศࡋࡓࣂࢼࢼ㸦ࣛࣥࢡA㸧㸪࠿ࡲࡰࡇ㸦ࣛࣥ
ࢡB㸧㸪ࡾࢇࡈ㸦ࣛࣥࢡC㸧㸪㣗ࣃࣥ㸦ࣛࣥࢡD㸧㸪ࣇࣛࣥࢫࣃࣥ㸦ࣛࣥࢡE㸧ࡢྛ10mmゅ࡛࠶ࡿ㸬 ࿪ᄮ⤊ᮎ఩ࡢ ᐃ࡟ࡣARCUSdigmaϩࡢィ ࣔࢪ࣮ࣗࣝ㸦Motion Analysis㸧ࢆ⏝࠸ࡓ㸬 ᐇ㦂᪉ἲࡣ㸪ည㢌ᔐྜ఩ࢆグ㘓ࡋࡓᚋ࡟ྛ⿕㦂㣗ရࡢᕥྑഃ∦࿪ᄮࢆྛ5ᅇ⾜ࢃࡏ㸪ྠ୍㣗ရ࡟ࡘ
࠸࡚2ᅇグ㘓ࡋࡓ㸬 ศᯒࡣ⤫ྜࣉࣟࢢ࣒ࣛ㸦KaVo integrated Desktop㸪
࢝࣎ࢹࣥࢱࣝࢩࢫࢸ࣒ࢬࢪࣕࣃࣥ㸪ᮾி㸪᪥ᮏ㸧ୖ࡛㸪Ỉᖹ㠃ほ࡟࡚ྛ⿕㦂㣗ရู࡟ည㢌ᔐྜ఩࠿ࡽ࿪ᄮ⤊ᮎ఩ࡲ࡛ࡢᗙᶆࢆィ ࡋ㊥㞳ࢆ⟬ฟࡋࡓ㸬⿕᳨⪅㛫ࡢẚ㍑ࡣKruskal-Wallis᳨ᐃࢆ⏝࠸ࡓ.
Ϫ㸬 ⤖ᯝ࡜⪃ᐹ 㣗ရᛶ≧ࡢ㐪࠸ࡀ࿪ᄮ⤊ᮎ఩࡟࠾ࡼࡰࡍᙳ㡪ࢆ㸪࿪ᄮ㞀ᐖࢆ᭷ࡉ࡞࠸⿕㦂⪅࡞ࡽࡧ࡟࿪ᄮ㞀ᐖࢆ᭷ࡍࡿ⿕㦂⪅࡟ࡘ࠸࡚ࡑࢀࡒࢀ ᐃࡋẚ㍑ࡋࡓ⤖ᯝ㸪
 1. ୧⿕᳨⪅࡛඲⿕㦂㣗ရ࡟࠾࠸࡚㸪࿪ᄮ㐠ື㊰ࡢ⤊ᮎ఩ࡣ࿪ᄮ㛤ጞ࠿ࡽ࿪ᄮ⤊஢ࡲ࡛ẖᅇ࿪ᄮ⤊ᮎ఩࡟฿㐩ࡋ࡚࠸ࡓ㸬 2. ྠ୍⿕㦂㣗ရ࡟ࡘ࠸࡚⿕㦂⪅ࡢ࿪ᄮ㞀ᐖࡢ᭷↓࡟ࡼࡗ࡚᭷ពᕪࡀㄆࡵࡽࢀࡓ㸦⾲㸧㸬࿪ᄮ㞀ᐖࡢ᭷↓࡟ࡼࡿ᭷ពᕪ
㻌

࿪ᄮ㞀ᐖ↓

ᕥ

ᕥ

ྑ

㻌

࿪ᄮ㞀ᐖ᭷

ᕥ

ྑ

ᕥ

ྑ
ྑ

ࣂࢼࢼ

<0.001NS <0.001

 <0.05࠿ࡲࡰࡇ <0.001NS <0.001

 <0.01ࡾࢇࡈ <0.001

 <0.01 <0.001NS㣗ࣃࣥ <0.001

 <0.05

 <0.001

 <0.05ࣇࣛࣥࢫࣃࣥ

 <0.001

 <0.01 <0.001

NS 3. ⿕㦂㣗ရࡢ࿪ᄮഃ࡟࠾ࡅࡿ㸪࿪ᄮ⤊ᮎ఩࠿ࡽည㢌ᔐྜ఩ࡲ࡛ࡢᕪ␗ࡣ㸪࿪ᄮ㞀ᐖࢆ᭷ࡉ࡞࠸⿕㦂⪅࡛ࡣ⿕㦂㣗ရ㛫࡛ࡢ᭷ពᕪࡀ
ㄆࡵ࡞࠿ࡗࡓ㸬࿪ᄮ㞀ᐖࢆ᭷ࡍࡿ⿕㦂⪅࡛ࡣ⿕㦂㣗ရ㛫࡛ࡣ᭷ពᕪࡣㄆࡵࡽࢀࡎ㸪ྠ୍⿕㦂㣗ရ࡟࠾ࡅࡿᕥྑ࿪ᄮഃ㛫࡛ࡣ඲⿕㦂㣗ရ࡛᭷ព࡟ᕪࡀㄆࡵࡽࢀࡓ㸬 ௨ୖࡢࡇ࡜࠿ࡽ㸪࿪ᄮ㐠ື㊰ࡢ⤊ᮎ఩ࡣ ᐃ⿦⨨ࡸ㣗ရࡢ࠿ࡓࡉ࡟ࡼࡗ࡚ᙳ㡪ࢆཷࡅ࡞࠸ࡇ࡜ࡀ
᫂ࡽ࠿࡜࡞ࡗࡓ㸬ࡲࡓ⿕㦂⪅ࡢ࿪ᄮ㞀ᐖࡢ᭷↓ࡣ㸪㣗ရࡢ࠿ࡓࡉࡀ␗࡞ࡗ࡚ࡶည㢌ᔐྜ఩࠿ࡽ࿪ᄮ⤊ᮎ఩ࡲ࡛ࡢᕪ␗ࡣ㸪࿪ᄮ㞀ᐖࢆ᭷ࡍࡿ⿕᳨⪅ࡢ࡯࠺ࡀ኱ࡁ࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) ୰ᮧ೺ኴ㑻㸪ᯘᚨಇ㸪ᒣᮏྖᑗ㸪㏆⸨ᗣྐ㸪ᑠᓥᰤ἞㸪಴⏣㇏࡯࠿㸬㣗ရᛶ≧ࡢ㐪࠸ࡀ࿪ᄮ⤊ᮎ఩࡟ཬࡰࡍᙳ㡪㸫㣗ရࡢ࠿ࡓࡉ࡟ࡘ࠸
࡚㸫㸬᪥⿵⥛఍ㄅ 2013㸹5࣭122ᅇ≉ูྕ㸸
146㸬2) ᮅ಴⏤฼Ꮚ㸬඲㒊ᗋ⩏ṑ⿦╔⪅ࡢ࿪ᄮ⬟ຊホ౯ἲ࡟㛵ࡍࡿ◊✲ ࿪ᄮ⬟ຊ᳨ᰝ⾲࡟ࡘ࠸࡚㸬ឡ㝔኱ㄅ 1990㸹28㸸1267-1285.

− 142 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 12㉸㧗㏿MRIࢆ⏝࠸ࡓ࿪ᄮ㐠ື᫬ࡢୗ㢡㢌ࡢኚ఩㔞‫ۑ‬ᒣᮏྖᑗ㸪୰ᮧ೺ኴ㑻㸪㏆⸨ᗣྐ㸪ᯘ⿱ஂ㸪 ᡂ⏣⿱⣖ᮾᾏᨭ㒊㸪 ᮾ㛵ᮾᨭ㒊
Displacement of Temporomandibular Joint during Food Masticatory Movement to Deglutition using Ultrahigh-speed MRI
Yamamoto M, Nakamura K, Kondo Y, Hayashi H, *Narita Y
Tokai Branch, *Higashi-Kanto BranchϨ㸬 ┠ⓗ ࢃࢀࢃࢀࡣࡇࢀࡲ࡛㛵⠇෇ᯈࡸୗ㢡㢌ࡀື⏬
ⓗ㸪㐃ືⓗ࡟ほᐹࡀྍ⬟࡛࠶ࡿ㉸㧗㏿ MR ᧜ീἲ࡟ࡼࡿ೺ᖖ᭷ṑ㢡⪅࡜㢡ᶵ⬟␗ᖖ⪅ࡢ㢡㛵⠇㒊ࡢ ື ែ ࡟ࡘ࠸࡚ሗ࿌ࡋ࡚ࡁࡓ㸬ࡑࡢ࡞࠿࡛㣗ရ࿪ᄮ࠿ࡽᄟୗ࡟࠸ࡓࡿࡲ࡛ࡢ㢡㛵⠇㒊ࡢືែࢆ㉸㧗㏿ MRI ࡛ほᐹࡋࡓ⤖ᯝ㸪೺ᖖ᭷ṑ㢡⪅࠾ࡼࡧ㢡ᶵ⬟㞀ᐖ⪅࡜ࡶ࡟ྠᵝࡢືែࡀほᐹࡉࢀ㸪୧⪅࡜ࡶ⩦័ᛶ㛤㛢ཱྀ㐠ື᫬࡜ࡣ␗࡞ࡾᚤᑠ࡞⛣ື⠊ᅖ࡛࠶ࡾ㸪࿪ᄮ࣭ᄟୗ㐠ື࡟㢡㛵⠇㒊ࡢ㛵୚ࡀ㠀ᖖ࡟ᑡ࡞࠸ࡇ࡜ࢆሗ࿌ࡋࡓ 1)㸬
 ࡋ࠿ࡋ࡞ࡀࡽ㐠ືᵝ┦ࡢホ౯ࡣㄞീ་࡟ࡼࡿ
どぬⓗ࡞ホ౯ࡢࡳ࡛࠶ࡗࡓ㸬ࡑࡇ࡛௒ᅇࡣ㸪㣗ရ࿪ᄮ࠿ࡽᄟୗ࡟࠸ࡓࡿࡲ࡛ࡢୗ㢡㢌ࡢ⛣ື㊥㞳ࢆィ ࡋ㸪ẚ㍑᳨ウ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣ㸪ᐇ㦂࡟ྠពࡀᚓࡽࢀࡓ㸪▹ṇࡢ᪤ ࡀ࡞ࡃ㸪ⴭࡋ࠸୙ṇညྜࡀㄆࡵࡽࢀ࡞࠸㸪㢡㛵⠇⑕⑕≧࡞ࡽࡧ࡟࿪ᄮ㞀ᐖࢆ᭷ࡉ࡞࠸೺ᖖ᭷ṑ㢡⪅
㸦NA㸧⏨ᛶ1ྡ㸸34ṓ㸪࠾ࡼࡧ࿪ᄮ㞀ᐖࢆ⮬ぬࡍࡿ㢡ᶵ⬟㞀ᐖ⪅㸦UA㸧⏨ᛶ1ྡ㸸39ṓ࡛࠶ࡿ㸬 MRI⿦⨨㸦Acheiva Nova Dual 1.5T㸪ࣇ࢕ࣜࢵࣉ
ࢫ㸪࢔࣒ࢫࢸࣝࢲ࣒㸪࢜ࣛࣥࢲ㸧ࢆ౑⏝ࡋ㸪᧜ᙳ⏝ࢥ࢖ࣝ࡟ࡣ┤ᚄ47mm Surface Microscopy Coilࢆ⏝࠸ࡓ㸬᧜ീ᪉ἲࡣBalanced FFEࢆ౑⏝ࡋ㸪㛵⠇෇ᯈࡢືែࡀ᭱ࡶ☜ㄆ࡛ࡁࡿྠ୍▮≧᩿㠃ୖ࡟࡚㸪
50⛊㛫࡟100᧜ീ࡜ࡋࡓ㸬 ᧜ീ᮲௳ࡣFHᖹ㠃ࡀ᧜ീྎ࡜ᆶ┤࡟࡞ࡿࡼ࠺㢌㒊ࢆᅛᐃࡋ㸪50⛊㛫ෆ࡛࿪ᄮ࠿ࡽᄟୗࢆ⾜ࢃࡏࡓ㸬⿕㦂㣗ရࡣ10mmゅࡢ࠿ࡲࡰࡇ࡛࠶ࡿ㸬࿪ᄮ㐠ືࡣ
10⛊㛫ࡢᕥ࿪ᄮ㸦LC㸧ྑ࿪ᄮ㸦RC㸧ࢆ⾜࠸㸪ࡑࡢᚋᄟୗࡍࡿࡼ࠺ᣦ♧ࡋࡓ㸬 ୗ㢡㢌ࡢ⛣ື㊥㞳ࡢィ ࡟ࡣDICOMࣅ࣮ࣗ࢔㸦OsiriX2㸪OsiriX㈈ᅋ㸪ࢪࣗࢿ࣮ࣈ㸪ࢫ࢖ࢫ㸧ࢆ౑⏝ࡋࡓ㸬ィ Ⅼࡣ㢡㛵⠇❐ୖ⦕㦵ෆ㠃㸦MF㸧࠿ࡽୗ㢡㢌ୖ⦕㸦H㸧ࡲ࡛࡜ࡋ㸪᭱኱㐠ືⅬࡲ࡛ࡢ㊥㞳ࢆィ ࡋࡓ㸬ࢥࣥࢺ࣮ࣟࣝࡣ㛢ཱྀ᫬࡟࠾ࡅࡿ
ୗ㢡㢌ࡢ఩⨨㸦CC㸧࡜ࡋࡓ㸬 ẚ㍑ᑐ㇟࡜ࡋࡓ㐠ືࡣ⩦័ᛶ㛤㛢ཱྀ㐠ື࡛㸪ྍཬⓗ࡟⩦័ᛶ㛤㛢ཱྀ㐠ື㊰ࢆ෌⌧ࡉࡏ㸪๓㢌㠃ほ࡛ࡣୗ㢡࢜ࢺ࢞࢖㒊ࢆṇ୰▮≧㠃ୖ࡟㸪▮≧㠃ほ࡛ࡣည㢌ᔐྜ఩࠿ࡽ᭱኱㛤ཱྀ᫬㸦MO㸧ࡲ࡛⣙3⛊㛫࡛㛤ཱྀ㸪ည㢌ᔐྜ఩ࡲ࡛⣙3⛊㛫࡛㛢ཱྀࡍࡿ㐃⥆ⓗ࡞ືస࡜ࡋࡓ㸬 ィ ࡋࡓୗ㢡㢌ࡢ㊥㞳ࢆKruskal-Wallis᳨ᐃ࡟࡚ゎᯒࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ 㣗ရ࿪ᄮ࠿ࡽᄟୗ࡟࠸ࡓࡿࡲ࡛ࡢ㢡㛵⠇㒊ࡢືែࢆ㉸㧗㏿MRI࡛᧜ീࡋ㸪ୗ㢡㢌ࡢ⛣ື㊥㞳ࢆィࡋࡓ⤖ᯝ㸦⾲㸧㸪
 1. ⿕᳨⪅NA㸪UA࡜ࡶ࡟CC࡜ẚ㍑ࡋࡓMO࡛ࡣᕥྑഃ㢡㛵⠇࡛ពᕪࡀㄆࡵࡽࢀࡓ㸬RC࡛ࡣᕥഃ㢡㛵⠇࡟᭷ពᕪࡀㄆࡵࡽࢀࡓ㸬 2. ⿕᳨⪅NA㸪UA࡜ࡶ࡟MOࡼࡾࡶ࿪ᄮഃ࡛ࡢ
ୗ㢡㢌ࡢ⛣ື㊥㞳࡟᭷ពᕪࡀㄆࡵࡽࢀࡓ㸬MF࠿ࡽHࡲ࡛ࡢ㊥㞳㸦cm㸧
NA

CC

MO

LC

RC

Mean

Left

0.17

1.29

0.50

0.93

SD

TMJ

0.04

0.05

0.11

0.17

CC

MO

RC

LC

Right

0.12

1.17

0.48

0.48

TMJ

0.04

0.05

0.13

0.14

UA

CC

MO

LC

RC

CC

MO

RC

LC

Mean

Left

0.48

1.97

0.56

0.60

Right

0.28

1.79

0.47

0.86

SD

TMJ

0.02

0.04

0.20

0.19

TMJ

0.05

0.06

0.05

0.19

 ௨ୖࡢࡇ࡜࠿ࡽ㸪೺ᖖ᭷ṑ㢡⪅࠾ࡼࡧ㢡ᶵ⬟㞀ᐖ⪅࡜ࡶ࡟ᕥྑഃ࿪ᄮഃ࡛ࡢ⛣ື㊥㞳ࡣ㸪᭱኱㛤ཱྀ᫬࡜ẚ㍑ࡋ࡚ᑠࡉ࠿ࡗࡓ㸬ࡲࡓ㛢ཱྀ᫬࡜ᕪࡀ࡞
࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) ᒣᮏྖᑗ㸪୰ᮧ೺ኴ㑻㸪㏆⸨ᗣྐ㸪ᒸୗ៞ኴ㑻㸪బ⸨ṇᙲ㸪ᮾ㧗ኈ㸬㉸㧗㏿MRIࢆ⏝࠸ࡓ㣗ရ࿪ᄮ࣭ᄟୗ㐠ື࡟࠾ࡅࡿ㢡㛵⠇㒊ࡢືែほᐹ㸬᪥⿵⥛఍ㄅ2014 6࣭123ᅇ≉ูྕ㸸
117㸬

− 143 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 13㧗㱋⪅࡟࠾ࡅࡿ⩏ṑࡢ⿦╔≧ែ࡛ࡳࡓ࿪ᄮ⬟ຊ‫⏣ۑ‬୰ඃ㤶㸪ᚿ㈡ ༤㸪୰ᓥ㑥ஂ㸪ᑠぢ㔝┿᲍ᜨ㸪ᶓᒣṇ㉳㸪㧗ⲡᮌ❶᪥ᮏṑ⛉኱Ꮫ⏕࿨ṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨1ㅮᗙ
Masticatory Performance as Seen from the Condition of Wearing Denture in Elderly Adults

Tanaka Y㸪Shiga H㸪Nakajima K㸪Komino M㸪Yokoyama M㸪Takakusaki A
Department of Partial and Complete Denture, The Nippon Dental University School of Life Dentistry atTokyo,Ϩ㸬 ┠ⓗ ࿪ᄮ⬟ຊࡣ㸪࿪ᄮᶵ⬟ࢆᐈほⓗ࡟ホ౯ࡍࡿࡓࡵࡢ㔜せ࡞ᣦᶆࡢ1ࡘ࡟࠶ࡆࡽࢀ࡚࠸ࡿࡀ㸪ညྜ≧ែ࡟ࡼࡾᙳ㡪ࢆཷࡅࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ1,2)㸬ᮏ◊✲ࡣ㸪㧗㱋⪅ࡢ࿪ᄮ⬟ຊࢆ᫂ࡽ࠿࡟ࡍࡿ┠ⓗ࡛㸪ညྜ≧ែ࡟␃ពࡋ㸪㧗㱋⪅࡟࠾ࡅࡿࢢ࣑ࢮ࣮ࣜ࿪
ᄮ᫬ࡢࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࢆศᯒࡋࡓ㸬ϩ㸬 ᪉ἲ ᮏ◊✲ࡣ㸪᪥ᮏṑ⛉኱Ꮫ⏕࿨ṑᏛ㒊ࡢ೔⌮ጤဨ఍ࡢᢎㄆࡢࡶ࡜࡟⾜ࡗࡓ㸬
1. ⿕㦂⪅⿕㦂⪅ࡣ㸪ᮾி㒔㇏ᓥ༊ಖ೺⚟♴㒊୺ദࡢ㇏ᓥ
༊ࡩࡃࡋ೺ᗣࡲࡘࡾ࡟ཧຍࡋࡓேࠎࡢ୰࠿ࡽ㸪㧗㱋⪅106ྡ㸦65㹼89ṓ㸪ᖹᆒ74.0ṓ㸧ࢆ㑅ᢥࡋࡓ㸬
2. グ㘓࡜ศᯒ᪉ἲ
ᐇ㦂ࡣ㸪⿕㦂⪅࡟ࢢ࣑ࢮ࣮ࣜࢆ୺࿪ᄮഃ࡛20⛊㛫࿪ᄮࡉࡏࡓ᫬ࡢࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࢆ ᐃࡋࡓ㸬ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࡣ㸪ࢢ࣑ࢮ࣮ࣜࢆ࿪ᄮᚋ㸪Ỉ
10 mlࢆྵࡳ㸪ℐ㐣௜ࢥࢵࣉ࡟ྤࡁฟࡉࡏ࡚ℐᾮࢆ᥇ྲྀࡋ㸪ࡇࡢℐᾮࡢࢢࣝࢥ࣮ࢫ⃰ᗘࢆࢢࣝࢥ࣮ࢫ
ᐃᶵჾ࡛ ᐃࡋࡓ㸬ศᯒࡣ㸪ࡲࡎࢢࣝࢥ࣮ࢫࡢ
⁐ฟ㔞࡟ࡘ࠸࡚⩏ṑ࡞ࡋ㸦᭷ṑ㢡⪅㸧⩌㸦1⩌㸧࡜⩏ṑ⿦╔⩌࡜ࡢ㛫࡛ẚ㍑ࡋࡓ㸬ḟ࠸࡛㸪⩏ṑ⿦╔⩌ࢆ∦㢡㒊ศᗋ⩏ṑ⿦╔⩌㸦2⩌㸧㸪ୖୗ㢡㒊ศᗋ⩏ṑ⿦╔⩌㸦3⩌㸧㸪㒊ศᗋ⩏ṑ࡜඲㒊ᗋ⩏ṑ⿦╔⩌㸦4⩌㸧㸪ୖୗ㢡඲㒊ᗋ⩏ṑ⿦╔⩌㸦5⩌㸧࡟ศࡅ㸪5⩌ࡢࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡟ࡘ࠸࡚㸪ከ㔜ẚ㍑
ࢆ⾜ࡗࡓ㸬ࡉࡽ࡟㸪඲⿕㦂⪅࡟࠾࠸࡚㸪ᖺ㱋࡜ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀࢆㄪ࡭ࡓᚋ㸪ྛ⩌࡟࠾࠸࡚ᖺ㱋࡜ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀࢆㄪ࡭ࡓ㸬࡞࠾㸪ࡍ࡭࡚ࡢࢹ࣮ࢱࡣ㸪⤫ィࢯࣇࢺ࢚࢘࢔㸦SPSS for Windows 10.0J, SPSS, Chicago, IL, USA㸧࡛ศᯒࡋࡓ㸬⿕㦂⪅⩌㛫ࡢẚ㍑ࡣ㸪୍ඖ㓄⨨ศᩓศᯒࢆ⾜࠸㸪᭷ពᕪࡀㄆࡵࡽࢀࡓሙྜ㸪Bonferroni
ࡢከ㔜ẚ㍑᳨ᐃࢆ⾜ࡗࡓ㸬ࡲࡓ㸪ᖺ㱋࡜ࢢࣝࢥ࣮
ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀࡣ㸪Pearsonࡢ┦㛵ಀᩘࢆ⟬ฟࡋ㸪┦㛵ࡢ᭷↓ࢆㄪ࡭ࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1. ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞⩏ṑ࡞ࡋ㸦᭷ṑ㢡⪅㸧⩌࡜⩏ṑ⿦╔⩌ࡢࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࡣ㸪⩏ṑ⿦╔⩌ࡢ࡯࠺ࡀ⩏ṑ࡞ࡋ⩌ࡼࡾࡶ᭷ព࡟ᑡ࡞࠿ࡗࡓ㸬ࡲࡓ⩏ṑ⿦╔⩌ࢆ⩏ṑ⿦╔≧ែ࡟ࡼࡾ4⩌࡟ศࡅࡓሙྜࡢྛ⩌ࡢࢢࣝࢥ࣮
ࢫࡢ⁐ฟ㔞ࡣ㸪1⩌㸦⩏ṑ࡞ࡋ⩌㸧ࡀ᭱ࡶከࡃ㸪2⩌㸪3⩌㸪4⩌㸪5⩌ࡢ㡰࡟ᑡ࡞ࡃ࡞ࡾ㸪1⩌࡜3⩌㸪
4⩌㸪5⩌࡜ࡢ㛫㸪2⩌࡜4⩌㸪5⩌࡜ࡢ㛫㸪3⩌࡜5⩌࡜ࡢ㛫࡟ࡑࢀࡒࢀ᭷ពᕪࡀㄆࡵࡽࢀࡓ㸬2. ᖺ㱋࡜ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀ඲⿕㦂⪅࡟࠾ࡅࡿᖺ㱋࡜ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀࡣ㸪୧⪅㛫࡟㈇ࡢ┦㛵ࡀㄆࡵࡽࢀࡓ㸬⩏ṑࡢ⿦╔ู࡟ࡳࡓᖺ㱋࡜ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜ࡢ㛵ಀࡣ㸪࠸ࡎࢀࡢ⩌࡟࠾࠸࡚ࡶ୧⪅㛫࡟୍ᐃࡢഴྥ
ࡀ࡞ࡃ㸪┦㛵ࡀㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬3. ࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪㧗㱋⪅࡟࠾ࡅࡿ࿪ᄮ⬟ຊࡣ㸪ṑࡢ႙ኻ࡟ࡼࡾ㸪⩏ṑࢆ⿦╔ࡋ࡚ࡶኳ↛ṑิ࡛ࡢ࿪ᄮ⬟ຊ࡟ẚ࡭ࡿ࡜పୗࡋ࡚࠸ࡿࡇ࡜㸪ࡲࡓညྜ≧ែࢆ⪃៖ࡋ࡞࠸࡜㸪ຍ㱋࡟ࡼࡾపୗࡍࡿ
ഴྥ࡟࠶ࡿࡇ࡜㸪ညྜ≧ែࢆ⪃៖ࡍࡿ࡜ᖺ㱋ࡢᙳ㡪ࢆཷࡅࡎ㸪ညྜ≧ែࡀኚ໬ࡋ࡞ࡅࢀࡤపୗࡋ࡞
࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) Hatch JP, Shinkai RS, Sakai S, Rugh JD,
Paunovich ED. Determinants of masticatory
performance in dentate adults. Arch Oral Biol
2001; 46 : 641-648.
2) Ikebe K, Matsuda K, Kagawa R, Enoki K,
Yoshida M, Maeda Y, et al. Association of
masticatory performance with age, gender,
number of teeth, occlusal force and salivary flowin Japanese older adults: is ageing a risk factor for
masticatory dysfunction? Arch Oral Biol 2011;56 : 991-996.

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日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 14㣗ရᦤྲྀ࢔ࣥࢣ࣮ࢺ࡟ࡼࡿ࿪ᄮ⬟ຊࡢホ౯‫ۑ‬ᒣᮏ᪩⧊㸪ᚿ㈡ ༤㸪⏣୰ ᙲ㸪ୖᮡ⳹Ꮚ㸪ᒸ⏣኱࿴㸪ᑠụ㯞㔛᪥ᮏṑ⛉኱Ꮫ⏕࿨ṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨1ㅮᗙ
Evaluation of Masticatory Performance Calculated Using a Food Intake Questionnaire

Yamamoto S, Shiga H, Tanaka A, Uesugi H, Okada Y, Koike M
Department of Partial and Complete Denture, The Nippon Dental University School of Life Dentistry at TokyoϨ㸬 ┠ⓗ ࿪ᄮ⬟ຊࢆホ౯ࡍࡿ୺ほⓗ࡞᪉ἲ࡜ࡋ࡚㸪㣗ရᦤྲྀ࢔ࣥࢣ࣮ࢺࢆ⏝࠸࡚㣗ရᦤྲྀ⬟ຊࢆㄪ࡭ࡿヨࡳࡀྂࡃ࠿ࡽ࠾ࡇ࡞ࢃࢀ࡚࠸ࡿ㸬ࡲࡓ㸪࢔ࣥࢣ࣮ࢺ⤖ᯝࢆࢫࢥ࢔໬ࡍࡿヨࡳࡀ࡞ࡉࢀ࡚࠾ࡾ㸪ࡑࡢ᭷⏝ᛶࡶ♧ࡉࢀ࡚࠸ࡿ1,2) ࡀ㸪㣗ရࡢ㑅ᢥࡸホ౯ἲ࡟ᨵⰋࡢవᆅࡀṧࡗ࡚࠸ࡿ㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪㣗ရᦤྲྀ࢔ࣥࢣ࣮ࢺ࡟ࡼࡿ࿪ᄮ⬟ຊࢆホ౯ࡍࡿࡇ࡜
࡛࠶ࡿ㸬
ϩ㸬 ᪉ἲ
⿕㦂⪅ࡣ㸪ᡂே200ྡ㸦20㹼89ṓ㸪ᖹᆒ57.5ṓ㸧ࢆ㑅ᢥࡋࡓ㸬⿕㦂⪅࡟Satoࡽ1)ࡀ㑅ᢥࡋࡓ20㣗ရ࡜
Koshionoࡽ2)ࡀ㑅ᢥࡋࡓ25㣗ရࢆྵࡴྜィ44✀㢮ࡢ㣗ရࡢᦤྲྀ≧ែ࡟ࡘ࠸࡚ᅇ⟅ࡉࡏࡓ㸬ḟ࠸࡛㸪
Satoࡽ1)ࡢ᪉ἲ࡛࿪ᄮࢫࢥ࢔MS1㸦⾲1㸧㸪Koshionoࡽ 2) ࡢ᪉ἲ࡛࿪ᄮࢫࢥ࢔MS2㸦⾲2㸧ࢆ⟬ฟࡋࡓ㸬ࡲࡓ㸪44㣗ရࡢᦤྲྀ≧ែ࢔ࣥࢣ࣮ࢺ⤖ᯝ࡟࠾࠸࡚㸪ࠕ᎘࠸ࡔ࠿ࡽ㣗࡭࡞࠸㸪㣗࡭ࡓࡇ࡜ࡀ࡞࠸ࠖ࡜ᅇ
⟅ࡋࡓ㣗ရ࡜ᮍグධࡢ㣗ရࢆ࡛ࡁࡿ㝈ࡾ㝖࠸ࡓ㣗ရࡢ୰࠿ࡽ20㣗ရࢆ㑅ᢥࡋ㸪20㣗ရ୰ࠕᬑ㏻࡟㣗࡭ࡽࢀࡿࠖ࡜ᅇ⟅ࡋࡓ㣗ရᩘࢆ5ಸࡋࡓ್ࢆ࿪ᄮࢫ
ࢥ࢔MS3࡜ࡋ࡚⟬ฟࡋࡓ㸬࿪ᄮ⬟ຊࡢᐈほⓗホ౯࡜ࡋ࡚㸪ࢢ࣑ࢮ࣮ࣜ࿪ᄮ᫬ࡢࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࢆ ᐃࡋࡓ㸬ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࡣ㸪ࡲࡎ⿕㦂⪅࡟ࢢ࣑ࢮ࣮ࣜࢆ୺࿪ᄮഃ࡛20⛊㛫࿪ᄮᚋ㸪⵨␃Ỉ
10 ml࡛Ὑཱྀࡋ㸪ࢢ࣑ࢮ࣮ࣜ࡜࡜ࡶ࡟ℐ㐣௜ࢥࢵࣉ࡟ྤࡁฟࡉࡏࡓ㸬ḟ࠸࡛㸪ℐᾮ୰ࡢࢢࣝࢥ࣮ࢫ⃰ᗘࢆࢢࣝࢥ࣮ࢫ ᐃᶵჾ࡛ ᐃࡋࡓ㸬ศᯒࡣ㸪ࢢࣝ ࢥ ࣮ ࢫ ࡢ⁐ฟ㔞࡜࿪ᄮࢫࢥ࢔㸦MS1 㸪MS2 㸪
MS3㸧࡜ࡢ㛵ಀ㸪3✀㢮ࡢ࿪ᄮࢫࢥ࢔㛫ࡢ㛵ಀࢆㄪ࡭ࡓ㸬ࡇࢀࡽࡢ㛵ಀࡣ㸪Pearsonࡢ┦㛵ࢸࢫࢺࢆ⏝࠸࡚⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
 1. ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞࡜࿪ᄮࢫࢥ࢔࡜ࡢ㛵ಀࡣ㸪MS1㸪MS2㸪MS3ࡢ࠸ࡎࢀ࡟࠾࠸࡚ࡶ࿪ᄮࢫ
ࢥ࢔ࡀ኱ࡁ࠸࡯࡝ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞ࡀከࡃ㸪ࡑࢀࡒࢀṇࡢ┦㛵ࡀㄆࡵࡽࢀࡓ㸬2. 3✀㢮ࡢ࿪ᄮࢫࢥ࢔㛫ࡢ㛵ಀࡣ㸪࠸ࡎࢀࡢ⾲1 ࿪ᄮ䝇䝁䜰䠄MS1䠅䛾⟬ฟἲ
㣗ရ⩌

⩌

Ϩ
ϩ
Ϫ
ϫ
Ϭ

䛸䛖䜅䠈䛤䛿䜣䠈䛖䛹䜣䠈䝥䝸䞁䝺䝍䝇䠈䜶䝡ኳ䜇䜙䠈䛝䜕䛖䜚䠈↝䛝䜒䛱ᰂ䜙䛛䛔䝇䝔䞊䜻䠈䛯䛟䛒䜣䠈㓑䛰䛣䠈◳䛔䝡䝇䜿䝑䝖䛚䛣䛧䠈◳䛔䛫䜣䜉䛔䠈䛸䜚㈅䠈ྂ䛔䛯䛟䛒䜣䛩䜛䜑䠈䜺䝮䠈䜚䜣䛤୸䛛䛨䜚䠈஝⇱䛧䛯㈅ᰕ

䕿:ᬑ㏻䛻㣗䜉䜙䜜䜛䠈䕧:ᕤኵ䛩䜜䜀㣗䜉䜙䜜䜛㽢:㣗䜉䜙䜜䛺䛔
࿪ᄮ䝇䝁䜰䠙䕿䛾䛴䛔䛯㣗ရᩘ / 20㽢100 䠄%䠅

⾲2 ࿪ᄮ䝇䝁䜰䠄MS2䠅䛾⟬ฟἲ⩌ẚ ᖹᆒᚓⅬ䠄䠆䠅

Ϩ

1.00

A

ϩ

1.06

B

Ϫ

1.22

C

ϫ

1.39

D

Ϭ

2.23

E

㣗ရ⩌

䝞䝘䝘䠈䠄䜖䛷䠅䛝䜓䜉䛴䠈䠄↻䠅ேཧ䠈䠄↻䠅䛥䛸䛔䜒䠈䠄↻䠅⋢䛽䛞䛔䛱䛤䠈䝝䝮䠈䛛䜎䜌䛣䠈ఢ↻䛣䜣䜆䠈䛣䜣䛻䜓䛟䠄ᥭ䠅㭜⫗䠈䠄↝䠅㭜⫗䠈䜚䜣䛤䠈䠄ₕ䠅䛺䛩䠈䠄⏕䠅䛝䜓䜉䛴䠄↝䠅㇜⫗䠈䠄ₕ䠅䛰䛔䛣䜣䠈䛒䜙䜜䠈䝢䞊䝘䝑䝒䠈䜲䜹่㌟
䠄⏕䠅ேཧ䠈䛯䛟䛒䜣䠈㓑䛰䛣䠈䛩䜛䜑䠈䛒䜟䜃

2 :ᐜ᫆䛻㣗䜉䜙䜜䜛䠈1 :ᅔ㞴䛰䛜㣗䜉䜙䜜䜛䠈0 :㣗䜉䜙䜜䛺䛔䕕:᎘䛔䛰䛛䜙㣗䜉䛺䛔䠈㣗䜉䛯䛣䛸䛜䛺䛔࿪ᄮ䝇䝁䜰䠙䠄A+1.06B+1.22C+1.39D+2.23E䠅 / 13.8㽢100䠄%䠅
䠄䠆䠅䠖䕕䜢䝬䞊䜽䛧䛯䜒䛾䜢㝖䛔䛯ྛ㝵⣭䛾5㣗ရ䛻䛴䛔䛶䚸ᖹᆒᚓⅬ䜢⟬ฟ

2࿪ᄮࢫࢥ࢔㛫࡟࠾࠸࡚ࡶṇࡢ┦㛵ࡀㄆࡵࡽࢀࡓ㸬3. ࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪ᐈほⓗホ౯࡟ࡼࡿ࿪ᄮ
⬟ຊ㸦ࢢࣝࢥ࣮ࢫࡢ⁐ฟ㔞㸧ࡣ㸪୺ほⓗホ౯࡟ࡼࡿ࿪ᄮ⬟ຊ㸦㣗ရᦤྲྀ⬟ຊ㸧ࡀ㧗࠸࡯࡝㧗࠸ࡇ࡜㸪3✀㢮ࡢ࿪ᄮࢫࢥ࢔ࡣ㸪࠸ࡎࢀࡶ᭷⏝࡛࠶ࡿࡇ࡜ࡀ
♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) Sato Y, Minagi S, Akagawa Y, Nagasawa T. An
evaluation of chewing function of complete
denture wearers. J Prosthet Dent 1989; 62: 50-53.
2) Koshino H, Hirai T, Toyoshita Y, Yokoyama Y,
Tanaka M, Iwasaki K, et al. Development of new
food intake questionnaire method for evaluating
the ability of mastication in complete denture
wearers. Prosthodontic Res Pract 2008; 7: 12-18.

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第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 15୺ᶵ⬟㒊఩࠿ࡽࡳࡓ࿪ᄮ⬟ຊ᳨ᰝἲࡢ᳨ウ‫ۑ‬୰ᮧ೺ኴ㑻㸪ᒣᮏྖᑗ㸪㏆⸨ᗣྐ㸪ᑠᓥᰤ἞*㸪಴⏣㇏**㸪ᐩ⃝೔***㸪ᒸᮏ┤ᶞ****㸪 ᒸୗ៞ኴ㑻*****㸪⚟ἑ⿱ᇶ*****㸪෠⏣┿୍*****㸪బ⸨ṇᙲ******㸪ᮾ㧗ኈ**ᮾᾏᨭ㒊㸪*す㛵ᮾᨭ㒊㸪**ᮾ㛵ᮾᨭ㒊㸪***ᮾிᨭ㒊㸪****஑ᕞᨭ㒊㸪*****㛵すᨭ㒊㸪******
୰ᅜ࣭ᅄᅜᨭ㒊
Examination about Inspecction of Mastication Ability from Main Occluding Area
Nakamura K, Yamamoto M, Kondo Y, Kojima* E, Kurata Y**, Tomizawa O***, Okamoto N****, Okashita
K*****, Fukuzawa H*****, Tomita S*****, Sato M******, Higashi T**
Tokai Branch, *Nishi-Kanto Branch, **Higashi-Kanto Branch, ***Tokyo Branch, ****Kyusyu Branch,*****
Kansai Branch, ******Chugoku-Shikoku BranchϨ㸬 ┠ⓗ ୺ᶵ⬟㒊఩ࡣ࿪ᄮࢆ⾜࠺࡟࠶ࡓࡾ㸪◳ᛶ㣗ရࢆ⢊○ࡍࡿ⮻ṑ㒊ࡢ࠶ࡿᐃࡲࡗࡓ㒊఩࡛࠶ࡿ1)㸬୺ᶵ⬟㒊఩࡟ࡘ࠸࡚ࡣ㸪ࡑࡢከࡃࡀཝᐦ࡞ညྜࢆ᭷ࡍ
ࡿୖୗ㢡➨୍኱⮻ṑ㛫࡟Ꮡᅾࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟
࡞ࡗ࡚࠸ࡿ㸬 ࡋ࠿ࡋ࡞ࡀࡽ➨୍኱⮻ṑ࡟ཝᐦ࡞ညྜ᥋ゐࢆ௜୚ࡋ࡚ࡶ㸪୍ᐃࡢ఩⨨࡟୺ᶵ⬟㒊఩ࡀ཰᮰ࡋ࡞࠸
⑕౛ࢆ┠࡟ࡍࡿࡇ࡜ࡀ࠶ࡿ㸬ࡑࡢࡓࡵࢃࢀࢃࢀࡣ
どぬⓗ࡟୺ᶵ⬟㒊఩ࡀ୍ᐃࡋ࡞࠸ࡇ࡜࡜㸪࿪ᄮ⤊ᮎ఩࠾ࡼࡧည㢌ᔐྜ఩ࡀ୍⮴ࡋ࡞࠸ࡇ࡜࡟㛵㐃ࡀ࠶ࡿࡇ࡜ࢆሗ࿌ࡋࡓ2)㸬
 ௒ᅇࡣ୺ᶵ⬟㒊఩ࡀ୍ᐃࡋ࡞࠸ᝈ⪅ࡢ࿪ᄮ⬟ຊ᳨ᰝἲ࡟ࡘ࠸࡚㸪ᅽᖹࡉࢀࡓࢫࢺࢵࣆࣥࢢࡢ㠃✚ࢆ᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣᐇ㦂࡬ࡢྠពࡀᚓࡽࢀࡓ㸪࿪ᄮ㞀ᐖࢆ⮬ぬࡏࡎ㸪୺ᶵ⬟㒊఩ࡀ୍ᐃࡢ఩⨨ࢆ♧ࡋ㸪࿪ᄮ⤊ᮎ఩ࡀည㢌ᔐྜ఩࡟୍⮴ࡋ࡚࠸ࡿ⪅ࢆࢥࣥࢺࣟ
࣮ࣝ࡜ࡋ࡚タᐃࡋࡓ㸬ࡇࢀ࡟ᑐࡋ࿪ᄮ㞀ᐖࢆ⮬ぬࡍࡿ᭷ṑ㢡⪅10ྡ㸦⏨ᛶ4ྡ㸪ዪᛶ6ྡ㸸32ࠥ69ṓ㸧ࢆᑐ㇟࡜ࡋ㸪⿕㦂ഃࡣ࿪ᄮ㞀ᐖࢆ⮬ぬࡍࡿᕥྑഃ
࠸ࡎࢀ࠿࡜ࡋࡓ㸬 ୺ᶵ⬟㒊఩ࡢุᐃࡣຍ⸨ࡢ᪉ἲ 1) ࡟ᚑ࠸㸪┤ᚄ
3.4mm4.0mmࡢࢫࢺࢵࣆࣥࢢ㸦ࢸ࣏࣮ࣥࣛࣜࢫࢺ
ࢵࣆࣥࢢ㸪GC㸪ᮾி㸧ࢆ⏝࠸࡚ჶࡳࡸࡍ࠸㒊఩࡟
࠾࠸࡚1ᅇࡢჶࡳࡋࡵࢆ⾜ࢃࡏ㸪ࡇࢀࢆ⿕㦂ഃ࡟ࡘ࠸࡚5ᅇ⾜ࡗࡓ㸬᥇ᚓࡉࢀࡓࢫࢺࢵࣆࣥࢢࡢ఩⨨ࡀṑิୖ୍࡛ᐃ࡛࡞࠸ࡇ࡜ࢆ☜ㄆࡋࡓ㸬 ゎᯒ࡟ඛ❧ࡕ㸪ᇶᗏ㠃࠿ࡽညྜᖹ㠃ࡲ࡛ࡢ㊥㞳
ࢆ18mm࡟ㄪᩚࡋࡓୗ㢡ᶍᆺୖ࡟㸪ჶࡳࡋࡵࡽࢀࡓ
5ಶࡢࢫࢺࢵࣆࣥࢢࡢ࠺ࡕ1ಶࡎࡘ㐺ྜࡉࡏࡓ≧ែࢆ෌⌧ࡋ㸪ࡇࡢ≧ែࢆṑ᥋ゐศᯒ⿦⨨㸦ࣂ࢖ࢺ࢔࢖BE-I㸪GC㸪ᮾி㸪᪥ᮏ㸧࡛᧜ᙳࡋࡓ㸬᧜ᙳ᮲௳
ࡣShoot mode࡛᧜ᙳಸ⋡60%࡜ࡋ㸪ࢹ࢕ࢫࣉࣞ࢖ୖ
ࡢ༑Ꮠ⥺ࡢ⦪⥺ࢆୗ㢡୰ษṑࡢ㞄᥋㠃᥋ゐⅬ࡟㸪ᶓ⥺ࢆᕥྑ➨2ᑠ⮻ṑ࡜➨1኱⮻ṑࡢ㞄᥋㠃᥋ゐⅬ࡟タ⨨ࡋ㸪⏬ീࢹ࣮ࢱ࡜ࡋ࡚グ㘓ࡋࡓ㸬ᚓࡽࢀࡓ⏬ീࢹ࣮ࢱࢆ⏬ീฎ⌮ゎᯒࢯࣇࢺ㸦Image J㸪NIH,㸪Bethesda㸪USA㸧ࢆ⏝࠸࡚୺ᶵ⬟㒊఩ࢆࡋࡵࡍᅽᖹࡉࢀࡓࢫࢺࢵࣆࣥࢢࢆ᳨ฟ࣭
㑅ᢥࡋ㸪ࡑࡢ㠃✚ࢆࣆࢡࢭࣝᩘ࡜ࡋ࡚⟬ฟࡋࡓ㸬ࡇࡢ୺ᶵ⬟㒊఩㠃✚࡟ࡘ࠸࡚㸪ࢥࣥࢺ࣮ࣟࣝ࡜ࡢ
ẚ㍑ࡣDunnettࡢከ㔜ẚ㍑࡛⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ୺ᶵ⬟㒊఩ࡀ୍ᐃࡋ࡞࠸࿪ᄮ㞀ᐖࢆ⮬ぬࡍࡿ⿕᳨⪅࡟ᑐࡋ㸪୺ᶵ⬟㒊఩ࢆุᐃࡋࡓࢫࢺࢵࣆࣥࢢ
ࡢ㠃✚ࢆィ ࡋࡓ⤖ᯝ㸪
 1. ୺ᶵ⬟㒊఩ࡢ㠃✚ࡣ10ྡ୰7ྡࡀࢥࣥࢺ࣮ࣟ
ࣝ࡟ᑐࡋ࡚᭷ពᕪࡀㄆࡵࡽࢀࡓ㸦ᅗ㸧㸬
 2. ᭷ពᕪࡀㄆࡵࡽࢀࡓ⿕᳨⪅ࡢ୺ᶵ⬟㒊఩ࡢ㠃✚ࡣ㸪ࢥࣥࢺ࣮ࣟࣝࡢ㠃✚࡟ᑐࡍࡿ๭ྜ
ࡀ44.2ࠥ56.5%࡛࠶ࡗࡓ㸬
pixel
4000

*  <0.01

n=5

3000

*

2000

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*

*

*

*

*

1000

0

ᅽᖹࡉࢀࡓࢫࢺࢵࣆࣥࢢࡢࣆࢡࢭࣝᩘ ௨ୖࡢ⤖ᯝ࠿ࡽ㸪࿪ᄮ⬟ຊ᳨ᰝἲ࡟ࡣ୺ᶵ⬟㒊఩ุᐃࡢࡓࡵࡢࢫࢺࢵࣆࣥࢢ᳨ᰝ࠿ࡽᚓࡽࢀࡓࢫ
ࢺࢵࣆࣥࢢࡢ㠃✚ࡀ᭷⏝࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) ຍ⸨ᆒ㸬୺ᶵ⬟㒊఩࡟ᇶ࡙ࡃᐇ㊶ⓗညྜㄽ㸬ᮾி㸸ࢹࣥࢱࣝࢲ࢖ࣖࣔࣥࢻ♫㸹2010㸬2) ୰ᮧ ೺ኴ㑻㸪ᒣᮏྖᑗ㸪㏆⸨ᗣྐ㸪ᑠᓥᰤ἞㸪಴⏣㇏㸪ᐩ⃝೔࡯࠿㸬࿪ᄮ⤊ᮎ఩࡜୺ᶵ
⬟㒊఩࡜ࡢ㛵ಀ㸬᪥⿵⥛఍ㄅ 2014㸹6࣭123ᅇ≉ูྕ㸸113㸬

− 146 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 16࣒࢞࿪ᄮࡀጼໃไᚚ࡟ཬࡰࡍᙳ㡪㸫㢌㒊㸪యᖿ㸪㌟య㔜ᚰືᦂࡢ㛵㐃ᛶ࡟ࡘ࠸࡚㸫‫ۑ‬ᆏཱྀ ✲㸪ᓥ ᜨᏊ㸪୸ᒣ ᬛ❶㸨㸪ᶓᒣ ᩔ㑻໭ᾏ㐨኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ཱྀ⭍ᶵ⬟Ꮫㅮᗙཱྀ⭍ᶵ⬟⿵⥛Ꮫᩍᐊ*Ⲉᇛᕤᴗ㧗➼ᑓ㛛Ꮫᰯ 㟁Ẽ㟁Ꮚࢩࢫࢸ࣒ᕤᏛ⛉Effect of Masticating Chewing Gum on Postural Control System-Interrelationships between Head, Trunk and Body SwaysSakaguchi K, Shima K, Maruyama T, Yokoyama A
Department of Oral Functional Prosthodontics, Division of Oral Functional Science,
Graduate School of Dental Medicine, Hokkaido University*Department of Electrical and Electronic Systems Engineering, Ibaraki National College of TechnologyϨ㸬 ┠ⓗ 㢌㒊ࡣ㢕㒊ࢆ௓ࡋ࡚యᖿ࡟ᨭ࠼ࡽࢀ࡚࠾ࡾ㸪㢌㒊ືᦂࡣጼໃไᚚ࡟࠾࠸࡚㔜せ࡞せᅉ࡛࠶ࡿ㸬୍᪉㸪࿪ᄮ㐠ື᫬࡟ࡣ㸪ୗ㢡㐠ື࡜㢌㒊㐠ືࡢ༠ㄪᛶࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡋࡓࡀࡗ࡚㸪㢡ཱྀ⭍ᶵ⬟࡜ጼໃไᚚࡢ㛵㐃ᛶࢆゎ᫂ࡍࡿࡓࡵ࡟㸪࿪ᄮ㐠ືࡀ㸪㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂ࡟ཬࡰࡍᙳ㡪ࢆ᳨⣴ࡍࡿࡇ࡜ࡣ᭷ព⩏࡛࠶ࡿ㸬ࡉࡽ࡟㸪ࡇࢀࡽࡢ㛵㐃ᛶࢆゎ᫂ࡍࡿ࠺࠼࡛㸪㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂࡢ㛵㐃ᛶ࡟㛵ࡍࡿ᳨⣴ࡶ㔜せ࡛࠶ࡿ㸬 ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪࣒࢞࿪ᄮࡀ㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂ࡟ཬࡰࡍᙳ㡪࡜ࡇࢀࡽࡢືᦂ
ࡢ㛵㐃ᛶ࡟ࡘ࠸᳨࡚⣴ࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅࡟ࡣ㸪࿪ᄮ㐠ື⮬ືศᯒࢩࢫࢸ࣒ 1 㸧 ࢆ⏝࠸࡚㸪࣒࢞࿪ᄮࢆ⾜ࢃࡏࡓ࡜ࡁࡢ㐠ື⤒㊰ࡢ㔜ࡡྜࢃࡏ࡜ᖹᆒ⤒㊰ࡢ⾲♧ࢆ⾜࠸㸪ည㢌ᔐྜ఩࠿ࡽ
సᴗഃ࡟ྥ࠿ࡗ࡚㛤ཱྀࡋ㸪ည㢌ᔐྜ఩࡬㛢ཱྀࡍࡿࡀ㸪ည㢌ᔐྜ఩௜㏆ࡢ㛢ཱྀ㊰ࡀconvexࢆ࿊ࡍࡿ೺
ᖖ᭷ṑ㢡⪅10ྡ㸦ᖹᆒᖺ㱋26.5ṓ㸧ࢆ㑅ᢥࡋࡓ㸬 ୗ㢡Ᏻ㟼఩㸪ည㢌ᔐྜ఩㸪࣒࢞࿪ᄮ᫬ࡢ3᮲௳ୗ࡟࠾࠸࡚㸪⮬↛┤❧ጼໃ᫬ࡢ㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂࡢྠ᫬ィ ࢆ⾜ࡗࡓ㸬ィ ࡣ㸪㢌㒊ࡢᏳᐃࢆ┠ど࡛☜ㄆᚋ㸪ྛ᮲௳ୗ࡟࠾࠸࡚㸪㛤║
࡛20⛊㛫⾜ࡗࡓ㸬㢌㒊࡜యᖿࡢືᦂィ ࡣ㸪3ḟඖ⏬ീゎᯒࢩࢫࢸ࣒㸦ࡦࡲࢃࡾGE60/W4H㸪ࣛ࢖ࣈ࣮ࣛࣜ♫〇㸧ࢆ⏝࠸࡚㸪㢌㒊࡜యᖿ࡟ࡑࢀࡒࢀタᐃࡋࡓ4 ᐃⅬࡢືసゎᯒࢆ⾜ࡗࡓ㸬㢌㒊ືᦂࡢᏳᐃᛶࢆホ౯ࡍࡿࡓࡵ࡟㸪㢌㒊࡟タᐃࡋࡓ㸲 ᐃⅬࡢ㔜ᚰࡢᖹᆒᗙ
ᶆࢆ௬᝿୰ᚰ࡜ࡋ࡚㸪௬᝿୰ᚰ࡜ྛ㔜ᚰᗙᶆ࡜ࡢ
⤒᫬ⓗ㊥㞳ኚ໬ࢆ㢌㒊ືᦂ್࡜ᐃ⩏ࡋ࡚⏝࠸ࡓ㸬యᖿືᦂࡢホ౯࡟ࡘ࠸࡚ࡶྠᵝࡢィ⟬ࢆ⾜࠸㸪యᖿືᦂ್࡜ᐃ⩏ࡋ࡚⏝࠸ࡓ㸬
㌟య㔜ᚰືᦂࡢィ ࡣ㸪㊊ᗏᅽศᕸ ᐃࢩࢫࢸ࣒㸦࣐ࢵࢺࢫ࢟ࣕࣥ㸪ࢽࢵࢱ♫〇㸧ࢆ⏝࠸ࡓ㸬㌟
య㔜ᚰືᦂࡢᏳᐃᛶࢆホ౯ࡍࡿࡓࡵࡢᐃ㔞ⓗᣦᶆ࡜ࡋ࡚㸪㊊ᗏⲴ㔜୰ᚰ⛣ືࡢ⥲㌶㊧㛗࡜㠃✚㸦እ࿘㸪▴ᙧ㸪ᐇຠ್㸧ࢆ⏝࠸ࡓ㸬ྠᵝ࡟㸪ࣂࣛࣥࢫホ౯࡟ࡣ㸪๓ᚋ㸪ᕥྑࡢ㊊ᗏⲴ㔜ศᕸ್ࢆ⏝࠸ࡓ㸬 ⤫ィฎ⌮ࡣ㸪ࣇ࣮ࣜࢻ᳨࣐ࣥᐃ࡟ࡼࡾ⩌㛫ẚ㍑
ࢆ⾜࠸㸪ከ㔜ẚ㍑࡟ࡣ࣎ࣥࣇ࢙࣮ࣟࢽ⿵ṇ࢘࢕ࣝࢥࢡࢯ᳨ࣥᐃࢆ⏝࠸ࡓ㸬ࡉࡽ࡟㸪ྛᐃ㔞ⓗᣦᶆࡢ┦㛵ࢆ᳨⣴ࡍࡿࡓࡵ࡟ࢫ࣌࢔࣐ࣥ┦㛵ࢆ⏝࠸ࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1. 㢌㒊ືᦂ࡜యᖿືᦂ
㢌㒊࡜యᖿືᦂ್ࡣ࡜ࡶ࡟㸪ୗ㢡Ᏻ㟼఩㸪ည㢌ᔐྜ఩㸪࣒࢞࿪ᄮࡢ㡰࡟ᑠࡉࡃ࡞ࡗࡓ㸦p<0.05㸧㸬
2. ㌟య㔜ᚰືᦂ1) ㊊ᗏⲴ㔜୰ᚰ⛣ືࡢ⥲㌶㊧㛗࡜㠃✚㸦እ࿘㸪▴ᙧ㸪ᐇຠ್㸧ࡣ㸪ୗ㢡Ᏻ㟼఩㸪ည㢌ᔐྜ఩㸪࣒࢞࿪ᄮࡢ㡰࡟㸪ࡑࢀࡒࢀ▷ࡃ㸪ࡑࡋ࡚ᑠࡉࡃ࡞ࡗ
ࡓ㸦p<0.05㸧㸬
2) ๓ᚋ㸪ᕥྑࡢ㊊ᗏⲴ㔜ศᕸ್ࡣ㸪3᮲௳㛫࡛᭷ពᕪࡀㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬
3㸬㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂࡢ㛵㐃ᛶ1) 3᮲௳ࡍ࡭࡚࡟࠾࠸࡚㸪యᖿືᦂ್࡜㊊ᗏⲴ㔜୰ᚰ⛣ືࡢ㠃✚㸦እ࿘㸪▴ᙧ㸪ᐇຠ್㸧ࡢ㛫࡟ᙉ࠸┦㛵ࡀㄆࡵࡽࢀࡓ㸦p<0.05, rs0.75㸧㸬
2) ࣒࢞࿪ᄮ᫬࡟ࡣ㸪㢌㒊ືᦂ್࡜యᖿືᦂ್㸪㢌㒊ືᦂ್࡜㊊ᗏⲴ㔜୰ᚰ⛣ືࡢ㠃✚㸦እ࿘㸪▴ᙧ㸪ᐇຠ್㸧ࡑࢀࡒࢀࡢ㛫࡟┦㛵ࡀㄆࡵࡽࢀࡓ
㸦p<0.05, rs0.69㸧㸬
ࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪ୗ㢡Ᏻ㟼఩㸪ည㢌ᔐྜ఩ࢆ
20⛊㛫ಖᣢࡋࡓ᫬࡜ẚ㍑ࡋ࡚㸪࣒࢞࿪ᄮ᫬ࡣ㸪㌟
య㔜ᚰືᦂࡢࣂࣛࣥࢫ࡟ࡣᙳ㡪ࢆཬࡰࡉ࡞࠸ࡀ㸪㢌㒊ືᦂ㸪యᖿືᦂ㸪㌟య㔜ᚰືᦂࡀ᭱ࡶᑠࡉࡃ
࡞ࡾ㸪ࡑࢀࡒࢀࡢືᦂࡀ┦㛵ࢆࡶࡗ࡚ኚ໬ࡍࡿࡇ
࡜ࡀศ࠿ࡗࡓ㸬ࡋࡓࡀࡗ࡚㸪࣒࢞࿪ᄮࡣ㸪ጼໃไᚚ࡟ᙳ㡪ࢆཬࡰࡋ࡚㸪㢌㒊࡜యᖿࡢືᦂࡀᑠࡉࡃ
࡞ࡾ㸪ጼໃࡢᏳᐃᛶࢆ㧗ࡵࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) ᚿ㈡ ༤㸪ᑠᯘ⩏඾㸬࿪ᄮ㐠ືࡢศᯒ࡟ࡼࡿ
࿪ᄮᶵ⬟ࡢᐈほⓗホ౯࡟㛵ࡍࡿ◊✲㸬⿵⥛ㄅ
1990㸹34㸸1112-1126㸬

− 147 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 17࣒࢞ࡢ㔞ࡢ㐪࠸ࡀࢳ࣮ࣗ࢖ࣥࢢ࡟ࡼࡿ⢭⚄ⓗࢫࢺࣞࢫ⦆࿴ຠ
ᯝ࡟ཬࡰࡍᙳ㡪‫ۑ‬ᾏ㔝 ⯟㸪⏣ᆏᙲつ*㸪⳥ᆅឡ㈗㸪୰すᗣ㍜㸪㟷ᮌಇ᠇㸪ᩪ⸨♸ኴ㸪᰿ὠ⿱୍㸪ୖ⏣㈗அ㸪Ḉ஭ ⸅ᮾிṑ⛉኱Ꮫ⪁ᖺṑ⛉⿵⥛Ꮫㅮᗙ㸪*ᮾிṑ⛉኱Ꮫࣃ࣮ࢩࣕࣝࢹࣥࢳ࣮ࣕ⿵⥛Ꮫㅮᗙ
Influence of Gum Amount on Mental Stress Release by Chewing
Unno W, Tasaka A*, Kikuchi M, Nakanishi K, Aoki T, Saitou Y, Nedu Y, Ueda T, Sakurai K
Department of Removable Prosthodontics and Gerodontology, Tokyo Dental College*Department of Removable Partial Prosthodontics, Tokyo Dental CollegeϨ㸬 ┠ⓗ ࿪ᄮ࡟ࡼࡿ⢭⚄ⓗࢫࢺࣞࢫ⦆࿴࡟ࡘ࠸࡚ᵝࠎ࡞◊✲ࡀ࠶ࡿ㸬ࡑࡢ୰࡛㸪Taharaࡽࡣ⢭⚄ⓗࢫࢺࣞࢫ㈇Ⲵᚋ࡟ࢳ࣮ࣗ࢖ࣥࢢࢆ⾜࠺ࡇ࡜࡟ࡼࡗ࡚⢭⚄ⓗࢫࢺࣞࢫᣦᶆ࡛࠶ࡿၚᾮ୰ࢥࣝࢳࢰ࣮ࣝ⃰ᗘࡀῶᑡࡍࡿࡇ࡜ࢆ᫂ࡽ࠿࡟ࡋࡓ1)㸬ࡉࡽ࡟㸪ࢳ࣮ࣗ࢖ࣥࢢ᫬ࡢ㐠ື᮲௳࡜ࡋ࡚㏿ࡉ2)㸪ຊ3)㸪᫬㛫4)ࡀࢳࣗ
࣮࢖ࣥࢢ࡟ࡼࡿ⢭⚄ⓗࢫࢺࣞࢫ⦆࿴࡟ᙳ㡪ࢆཬࡰࡍࡇ࡜ࡶ᫂ࡽ࠿࡟ࡋ࡚ࡁࡓ㸬௒ᅇࡣࡑࢀࡽࡢ㐠ື᮲௳࡟࣒࢞ࡢ㔞ࡀᙳ㡪ࡍࡿࡇ࡜࡟╔┠ࡋ㸪࣒࢞ࡢ㔞ࡢ㐪࠸ࡀࢳ࣮ࣗ࢖ࣥࢢ࡟ࡼࡿ⢭⚄ⓗࢫࢺࣞࢫ⦆
࿴ຠᯝ࡟ཬࡰࡍᙳ㡪ࢆ᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬᪉ἲ ⿕㦂⪅ࡣ೺ᖖ᭷ṑ㢡⪅18ྡ㸦ᖹᆒᖺ㱋30±2ṓ㸧࡜ࡋ㸪30ศ㛫Ᏻ㟼ᚋ࡟ࢫࢺࣞࢫ㈇Ⲵ࡜ࡋ࡚ᬯ⟬ࢆ
30ศ㛫⾜ࢃࡏࡓ㸬ࡑࡢᚋ10ศ㛫ࡢࢳ࣮ࣗ࢖ࣥࢢࢆ
⾜࠸10ศ㛫Ᏻ㟼࡟ࡋ㸪ᐇ㦂ࢆ⤊஢࡜ࡋࡓ㸬ࢥࣥࢺ࣮ࣟࣝࡣࢳ࣮ࣗ࢖ࣥࢢ࡞ࡋ࡜ࡋࡓ㸬࣒࢞ࡢ㔞ࡢኚ໬࡜ࡋ࡚࣒࢞1ಶ࠾ࡼࡧ࣒࢞2ಶ࡛ࡢࢳ࣮ࣗ࢖ࣥࢢ
ࢆ⾜ࡗࡓ㸬ࢳ࣮ࣗ࢖ࣥࢢヨᩱࡣࢯࣇࢺࢱ࢖ࣉࡢ↓࿡࣒࢞1g㸦Rotte♫〇㸧ࢆ౑⏝ࡋࡓ㸬⢭⚄ⓗࢫࢺࣞࢫ≧ែࡢホ౯ࡢᣦᶆ࡜ࡋ࡚ၚᾮ୰ࢥࣝࢳࢰ࣮ࣝ⃰ᗘࢆ ᐃࡋ㸪ࢫࢺࣞࢫ㈇Ⲵ┤ᚋ࠿ࡽࢫࢺࣞࢫ㈇Ⲵ
10ศᚋࡢኚ໬⋡ࢆ⟬ฟࡋࡓ㸬ࢥࣝࢳࢰ࣮ࣝ⃰ᗘࡣ
Salivette㸦SARSTED♫〇㸧࡟࡚᥇ྲྀࡋࡓၚᾮ࠿ࡽ
࢝࢘ࣥࢱ࣮㸦᪥❧࢔࣓ࣟ࢝ࢹ࢕࢝ࣝ♫〇㸧ࢆ⏝࠸࡚ RIA ἲ ࡟ ࡚ ィ ࡋ ࡓ 㸬 ➽ 㟁 ィ ME3000P 㸦 Mega
Electronics♫〇㸧ࢆ⏝࠸࡚㸪୧ ည➽ࡢ⾲㠃➽㟁ᅗࢆᑟฟࡋ㸪10ศ㛫ࡢࢳ࣮ࣗ࢖ࣥࢢᅇᩘཬࡧ➽άື㔞ࢆ⟬ฟࡋࡓ㸬ࢫࢺࣞࢫ㈇Ⲵ30ศᚋ࠿ࡽྛ᮲௳ᚋ
ࡢࢥࣝࢳࢰ࣮ࣝ⃰ᗘࡢኚ໬⋡ࡣ཯᚟ ᐃ࡟ࡼࡿ୍
ඖ㓄⨨ศᩓศᯒᚋ㸪Bonferroni᳨ᐃࢆ⾜ࡗࡓ㸬࣒࢞ࡢಶᩘ࡟ࡼࡿ10ศ㛫ࡢࢳ࣮ࣗ࢖ࣥࢢᅇᩘཬࡧ➽άື㔞ࡢẚ㍑ࡣᑐᛂࡢ࠶ࡿt᳨ᐃࢆ⾜ࡗࡓ㸦=0.05㸧㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
ࢫࢺࣞࢫ㈇Ⲵ┤ᚋ࠿ࡽࢫࢺࣞࢫ㈇Ⲵ10ศᚋࡢၚᾮ୰ࢥࣝࢳࢰ࣮ࣝ⃰ᗘࡢኚ໬⋡ࡣ㸪࣒࢞1ಶࡢࢳ࣮ࣗ࢖ࣥࢢ࡟࠾࠸࡚ⴭࡋࡃῶᑡࡋ㸪࣒࢞1ಶ࡜Ᏻ㟼࠾ࡼࡧ࣒࢞1ಶ࡜࣒࢞2ಶ࡜ࡢ㛫࡟᭷ពᕪࢆㄆࡵࡓ㸬Ᏻ㟼࡜࣒࢞2ಶ࡜ࡢ㛫࡟ࡣ᭷ពᕪࢆㄆࡵ࡞࠿ࡗࡓ㸬
10 ศ 㛫 ࡢ ࢳ ࣗ ࣮ ࢖ ࣥ ࢢ ᅇ ᩘ ࡣ ࢞ ࣒ 1 ಶ ࡛
783.2±227ᅇ㸪࣒࢞2ಶ࡛1131.6ᅇ±229ᅇ࡛࠶ࡾ㸪᭷ព ᕪ ࢆ ㄆ ࡵ ࡓ 㸬 10 ศ 㛫 ࡢ ➽ ά ື 㔞 ࡣ ࢞ ࣒ 1 ಶ ࡛
18.7mVs㸪࣒࢞2ಶ࡛30.3mVs࡛࠶ࡾ㸪᭷ពᕪࢆㄆ
ࡵࡓ㸬ࢳ࣮ࣗ࢖ࣥࢢࡢ㏿ࡉࡣ࣒࢞1ಶ࡛ࡣ1.3±0.4ᅇ/⛊㸪2ಶ࡛ࡣ1.9±0.4ᅇ/⛊࡛࠶ࡾ㸪46.2%㏿ࡉࡀୖ
᪼ࡋ࡚࠸ࡓ㸬ࡇࢀࡲ࡛ࡢ◊✲࡟࠾࠸࡚㏿ࡉࡢୖ᪼ࡀ+5%⛬ᗘ࡛࠶ࢀࡤ㸪ࢫࢺࣞࢫ⦆࿴࡟ࡣ᭷ຠ࡛࠶
ࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡿࡇ࡜࠿ࡽ2)㸪௒ᅇࡢ࢞
࣒2ಶ࡟ቑ㔞ࡋࡓࡇ࡜࡟ࡼࡿ↓⌮࡞㏿ࡉࡢୖ᪼࡟ࡼ
ࡿࢳ࣮ࣗ࢖ࣥࢢᅇᩘࡢቑຍࡀ⿕㦂⪅ࡢ⑂ປ࠾ࡼࡧ
⢭⚄ⓗࢫࢺࣞࢫ≧ែ࡟ᙳ㡪ࢆཬࡰࡍࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬௒ᅇࡢ◊✲࡛㸪࣒࢞ࡢ㔞ࡢ㐪࠸ࡀࢳ࣮ࣗ࢖ࣥࢢ
࡟ࡼࡿ⢭⚄ⓗࢫࢺࣞࢫ⦆࿴ຠᯝ࡟ᙳ㡪ࢆཬࡰࡍࡇ
࡜ࡀ᫂ࡽ࠿࡜࡞ࡾ㸪2ಶࡼࡾࡶ1ಶ࡛ࢳ࣮ࣗ࢖ࣥࢢ
ࡍࡿ᪉ࡀࢫࢺࣞࢫ⦆࿴࡟᭷ຠ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉ
ࢀࡓ㸬
ϫ㸬 ᩥ⊩
1) Tahara Y, Sakurai K, Ando T. Influence ofChewing and Clenching on Salivary Cortisol
Levels as an Indicator of Stress. J Prosthodont
2007; 16: 129-135.
2) Tasaka A, Tahara Y, Sugiyama T, Sakurai K.
Influence of chewing rate on Salivary StressHormone Levels. J Jpn Prosthodont Soc 2008; 52:
482-487.
3) Soeda R, Tasaka A, Sakurai K. Influence ofchewing force on salivary stress markers as
indicator of mental stress. J Oral Rehabil 2012;
39: 261-269.
4) Tasaka A, Takeuchi K, Sasaki H, Yoshii T, Soeda
R, Ueda T, Sakurai K. Influence of chewing timeon salivary stress markers. J Prosthodont Res
2014; 58: 48-54.

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第1日

第 3 会場

一般口演発表1 ─ 3 ─ 18⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ㣫ᩱᛶ≧ࡢ㐪࠸࡟ࡼࡿ
GLP-1ࡢኚ໬

‫ Ⳣۑ‬ᝆᕼ㸪㇏ୗ⚈ྐ㸪బࠎᮌࡳ࡙࡯㸪ᕝすඞᘺ㸪᭳⏣ⱥ⣖㸪㉺㔝 ᑑ໭ᾏ㐨་⒪኱ᏛṑᏛ㒊ညྜ෌ᘓ⿵⥛Ꮫศ㔝The state of feed changes serection of GLP-1 in diabetic model mouse

Kan Y, Toyoshita Y, Sasaki M, Kawanishi K, Aita H, Koshino H
Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of HokkaidoϨ㸬 ┠ⓗ⢾ᒀ⑓ࡣ⏕ά⩦័⑓ࡢ1ࡘ࡛࠶ࡾ㸪⏕ά⩦័ࡀせᅉ࡜࡞ࡗ࡚Ⓨ⑕ࡍࡿ㸬⏕ά⩦័ࡢ1ࡘ࡛࠶ࡿ㣗⩦័ࡣ࣮࢝ࣟࣜᦤྲྀ㔞㸪ᰤ㣴ࡢ㉁࡞࡝⢾ᒀ⑓࡟㛵ಀࡍࡿ✀ࠎࡢࣇ࢓ࢡࢱ࣮ࢆྵࢇ࡛࠾ࡾ㸪࿪ᄮࡣࡑࡇ࡟
㛵ࢃࡿ㔜せ࡞ᅉᏊࡢ1ࡘ࡛࠶ࡿ㸬 ࢢࣝ࢝ࢦࣥࣛ࢖ࢡ࣌ࣉࢳࢻ㸫1㸦GLP-1㸧ࡣ࢖ࣥࢡࣞࢳࣥ࣍ࣝࣔࣥࡢ1ࡘ࡛㸪⮅⣽⬊࡟స⏝ࡋ࡚࢖ࣥࢫࣜࣥศἪࢆಁ㐍ࡋ㸪ୖ᪼ࡋࡓ⾑⢾ࢆᢚไࡍࡿ
స⏝ࢆᣢࡘ㸬GLP-1ࡣᑠ⭠ࡢ⭠ෆศἪ⣽⬊࡛࠶ࡿL⣽⬊࠿ࡽศἪࡉࢀ㸪୺࡜ࡋ࡚⾑⢾್ࡢୖ᪼㸪㣗≀࡟ࡼࡿ⭠⟶࡬ࡢᶵᲔⓗ่⃭࠾ࡼࡧ㏞㉮⚄⤒࡟ࡼࡾㄪᩚࢆཷࡅ࡚࠸ࡿ¹Ί㸬 ௒ᅇᡃࠎࡣ㸪࿪ᄮࡀ㏞㉮⚄⤒ࢆ௓ࡋ㸪GLP-1ࡢศἪࢆୖ᪼ࡉࡏࡿ࡜࠸࠺௬ㄝ
ࡢୗ㸪⢾ᒀ⑓ࣔࢹࣝື≀࡟࠾࠸࡚㸪ᅛᙧ㣫⫱㣫ᩱࡲࡓࡣᾮయ㣫⫱㣫ᩱࡢᦤྲྀ࡟ࡼࡿ࿪ᄮືែࡢ┦㐪ࡀ㸪⾑⢾್ࡢㄪ⠇࡟㛵୚ࡍࡿGLP-1ࡢศἪ࡬୚࠼
ࡿᙳ㡪࡟ࡘ࠸᳨࡚ウࡋࡓ㸬ϩ㸬 ᪉ἲ ᐇ㦂ື≀࡟ࡣ8㐌㱋㞝ᛶc57BL/6J࣐࢘ࢫࢆ⏝࠸ࡓ㸬⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘ࢫస〇ࡢࡓࡵ㸪㣫ᩱ࡜ࡋ࡚⬡⫫ศ60㸣࣮࢝ࣟࣜẚ㧗⬡⫫㣫ᩱ㸦HFD-60㸪࢚࢜ࣜࣥࢱࣝ㓝ẕᕤᴗᰴᘧ఍♫㸧㸪⤒ཱྀ࣭⤒⟶୧⏝ᰤ㣴๣㸦࢚ࣥࢩࣗ࢔ࣜ࢟ࢵࢻ㸪ᰴᘧ఍♫᫂἞㸧ࢆ⏝࠸࡚
12㐌㛫㣫ᩱ⤥㣵ࢆ⾜ࡗࡓ㸬࣐࢘ࢫࡢయ㔜ཬࡧ⾑⢾
್ࡣ1㐌㛫ࡈ࡜࡟ ᐃࡋ㸪⾑⢾್ࡢ ᐃ࡟ࡣ⮬ᕫ᳨ᰝ⏝ࢢࣝࢥ࣮ࢫ ᐃჾ ࢽࣉࣟࣇ࣮ࣜࢫࢱ࢖ࣝࣇࣜ
࣮ࢲ࣒ࣛ࢖ࢺ㸪ࢽࣉࣟᰴᘧ఍♫ ࢆ⏝࠸ࡓ㸬ࡲࡓ12㐌㛫ᚋ㸪⤒ཱྀࢢࣝࢥ࣮ࢫ௜ຍヨ㦂᫬ࡢ⾑⢾್ࡢ᥎⛣ࢆㄪ࡭ࡓ㸬
ḟ࡟㸪㣫ᩱᦤྲྀᚋࡢGLP-1ࡢศἪ࡟ࡘ࠸᳨࡚ウࡋࡓ㸬࣐࢘ࢫࢆ24᫬㛫⤯㣗ࡉࡏࡓᚋ㸪ᅛᙧ㣫ᩱࢆᦤྲྀࡍࡿ⩌ࢆ࿪ᄮ⩌㸪ᾮయ㣫ᩱࢆᦤྲྀࡍࡿ⩌ࢆ㠀࿪ᄮ⩌࡜ࡋ㸪㣫ᩱᦤྲྀ㛤ጞ๓㸪30ศᚋ㸪60ศᚋ࠾
ࡼࡧ90ศᚋ࡟⾑ᾮࡢ᥇ྲྀࢆ⾜ࡗࡓ㸬᥇ྲྀࡋࡓ⾑ᾮࢆ⏝࠸㸪⾑⢾್ࡢ ᐃ࡜㸪⾑Ύ୰ࡢάᛶᆺGLP-1⃰ᗘࢆEnzyme Immuno Kit EIA 㸦ᰴᘧ఍♫ච␿⏕≀◊✲ᡤ㸧ࢆ⏝࠸࡚ ᐃࡋࡓ㸬⤫ィฎ⌮ࡣSPSSࢆ⏝࠸࡚Mann WhitneyࡢU᳨ᐃࢆ⾜࠸㸪᭷ពỈ‽p < 0.05࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ௒ᅇస〇ࡋࡓ⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘ࢫ࠾࠸࡚㸪㝶᫬⾑⢾࡛ࡣ252.3s60.1 mg/dl࡜࡞ࡾ㸪⤒ཱྀࢢࣝࢥ࣮ࢫ௜
ຍヨ㦂࡛ࡣ120ศࡢ᫬Ⅼ࡛205ᅵ30.3 mg/dl࡜࡞ࡗࡓ㸬 ࡇࡢస〇ࡋࡓ⢾ᒀ⑓ࣔࢹࣝື≀࡟ࡼࡗ࡚⾜ࢃࢀࡓ㣫ᩱᦤྲྀᚋࡢGLP-1ࡣ30ศࡢ᫬Ⅼ࡛㸪࿪ᄮ⩌࡛24.8
ᅵ7.7 pmol/l㸪㠀࿪ᄮ⩌࡛14.4ᅵ3.5 pmol/l࡜࡞ࡾ㸪᭷ព࡞ᕪࡀㄆࡵࡽࢀࡓ ᅗ p <0.05 㸬ࡇࡢ⤖ᯝ࠿ࡽ㸪⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ࿪ᄮ࡟ࡼࡿGLP1ࡢศἪಁ㐍ຠᯝࡣ㣫ᩱᦤྲྀᚋ30ศࢆ⤒㐣ࡍࡿ࡜⌧ࢀࡓ㸬⌧ᅾ㸪⢾ᒀ⑓἞⒪⸆࡜ࡋ࡚GLP-1ࢆศゎࡍࡿ㓝⣲࡛࠶ࡿDPP-ϫࡢ㜼ᐖ⸆ࡸGLP-1ཷᐜయసື⸆࡞
࡝ࡀ⏝࠸ࡽࢀ࡚࠸ࡿ㸬௒ᅇࡢ⤖ᯝ࡟ࡼࡾ㸪⢾ᒀ⑓ࣔࢹࣝື≀࡟࠾࠸࡚㸪࿪ᄮࡣGLP-1ࡢศἪࢆቑຍ
ࡉࡏࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ᅗ. ⢾ᒀ⑓ࣔࢹ࣐ࣝ࢘ࢫ࡟࠾ࡅࡿ㣫ᩱᦤྲྀᚋ 30ศ࡟࠾ࡅࡿ࿪ᄮ⩌࡜㠀࿪ᄮ⩌ࡢάᛶᆺ GLP-1 ⃰ᗘϫ㸬 ᩥ⊩1) Janssen P, Rotondo A, Mulé F, et al. A
comparison of glucagon-like peptides 1 and 2.
Aliment Pharmacol Ther 2013㸹37㸸18-36.

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第1日

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日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 19デ᩿⏝ࢫࣉࣜࣥࢺࢆ⏝࠸ࡓ╧╀᫬ࣈࣛ࢟ࢩࢬ࣒ࡢᐃ㔞ⓗホ౯‫ۑ‬ᖹ஭೺ኴ㑻㸪஭ᕝ▱Ꮚ㸪㔜⏣ඃᏊ㸪Ᏻ⸨ᰤ㔛Ꮚ㸪ᖹᯘ㔛኱㸪ᖹ஭┿ஓ㸪ᑠஂಖ⿱ྖ㸪Ἑᮧ ᪼*㸪ᑠᕝ ໶㸬㭯ぢ኱ᏛṑᏛ㒊ࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫㅮᗙ㸪*㭯ぢ኱ᏛṑᏛ㒊ṑ⛉ᢏᕤ◊ಟ⛉
Quantitative study of sleep bruxism with occlusal splint

Hirai K㸪Ikawa T㸪Shigeta Y㸪Ando E㸪Hirabayashi R㸪Hirai S㸪Kokubo Y㸪Kawamura N*㸪Ogawa T
Department of Fixed Prosthodontics㸪Tsurumi University School of Dental Medicine㸪*The Dental Technician Training Institute㸪Tsurumi University School of Dental MedicineϨ㸬┠ⓗ╧╀᫬ࣈࣛ࢟ࢩࢬ࣒ࡣ㸪㢡㛵⠇⑕ࡢⓎ⑕ᅉᏊ࡟ᣲ
ࡆࡽࢀࡿ࡯࠿㸪ṑ࿘⑌ᝈ㸪ṑࡢ◚ᢡ㸪ည⪖࡞࡝ࢆᘬࡁ㉳ࡇࡍ⩦Ⓑࡢ୍ࡘ࡛࠶ࡿ 1)㸬ࣈࣛ࢟ࢩࢬ࣒ࡣࢢࣛ
࢖ࢹ࢕ࣥࢢ㸪ࢡࣞࣥࢳࣥࢢ㸪ࢱࢵࣆࣥࢢ࡟ศ㢮ࡉࢀ㸪╧╀᫬࡟ぬ㓰᫬ࡢ᭱኱ညྜຊ௨ୖࡢညྜຊࡀⓎ⌧ࡍࡿ࡞࡝ࡢሗ࿌ࡶ࠶ࡾ㸪ࡑࡢ㉁࡜㔞ࡣಶࠎࡢ⑕౛࡛
ᵝࠎ࡛࠶ࡿࡇ࡜࠿ࡽ㸪⿵⥛ಟ᚟ฎ⨨ࢆ⾜࠺㝿࡟ࡣὀពࡀᚲせ࡛࠶ࡿ㸬╧╀᫬ࣈࣛ࢟ࢩࢬ࣒ࡢ ᐃࡣ࣏ࣜࢯ࣒ࣀࢢࣛࣇ
ࢆ⏝࠸ࡓ᳨ᰝ࡞࡝⢭ᐦ࡞᳨ᰝࡀᚲ㡲࡛࠶ࡿࡀ㸪ṑ⛉⮫ᗋ࡟࠾࠸࡚⡆౽࡟⏝࠸ࡿࡇ࡜ࡢ࡛ࡁࡿ᳨ᰝἲ
ࡀồࡵࡽࢀ࡚࠸ࡿ㸬➨123ᅇ౛఍࡟࠾࠸࡚㸪ᡃࠎࡣࢫࣉࣜࣥࢺࡢည⪖㔞࠿ࡽࣈࣛ࢟ࢩࢬ࣒ࡢ⛬ᗘࢆホ౯ࡋ㸪デ᩿ࡢ୍ຓ࡜ࡍࡿ┠ⓗ࡛ࠊ೺ᖖ⪅ࢆᑐ㇟࡟デ᩿⏝ࢫࣉࣜࣥࢺࡢ〇సἲ࡜ࡑࡢᛂ⏝࡟ࡘ࠸࡚ሗ
࿌ࡋࡓ㸬௒ᅇࡣ㸪ࣈࣛ࢟ࢩࢬ࣒ࢆ⮬ぬࡍࡿᝈ⪅ࢆᑐ㇟࡟㸪デ᩿⏝ࢫࣉࣜࣥࢺࡢ᭷⏝ᛶ࡟ࡘ࠸᳨࡚ウ
ࢆຍ࠼ࡓ㸬
ϩ㸬᪉ἲ
㸯㸬⿕᳨⪅
ᖹᡂ 26 ᖺ 7 ᭶࠿ࡽ 12 ᭶ࡲ࡛ࡢᮇ㛫࡟㭯ぢ኱ᏛṑᏛ㒊⿵⥛⛉㢡ཱྀ⭍ᶵ⬟␗ᖖእ᮶ࢆཷデࡋ㸪◊✲㊃᪨࡟ྠពࡋࡓ㸪ࣈࣛ࢟ࢩࢬ࣒ࢆ⮬ぬࡍࡿ೺ᖖ᭷ṑ㢡⪅ࢆᑐ㇟࡜ࡋࡓ㸬㝖እᇶ‽࡜ࡋ࡚ࡣ㸪㢡㛵⠇⑕ࡢ⮫ᗋ⑕≧㸪᪤ ࢆㄆࡵࡿࡶࡢ㸪୙ṇညྜ࡜ࡋࡓ㸬㸰㸬ᐇ㦂᪉ἲ
㸯㸧╧╀᫬ࣈࣛ࢟ࢩࢬ࣒ࡢホ౯╧╀᫬ࣈࣛ࢟ࢩࢬ࣒ࡢホ౯ࡣ㸪ࢫࣉࣜࣥࢺ⿦╔࡟ࡼࡿࣈࣛ࢟ࢩࢬ࣒ࡢኚ໬ࢆ☜ㄆࡍࡿ┠ⓗ࡛㸪⿦╔๓
ࡢ 3 ᪥㛫ィ ᚋ㸪ᮏ◊✲ࡢ┠ⓗ࡛࠶ࡿࢫࣉࣜࣥࢺ⿦
╔ᚋ㸵᪥㛫㸪14 ᪥㛫ࡢィ ࢆ⾜ࡗࡓ㸬౑⏝ᶵჾࡣ⡆᫆ᆺ➽㟁ィ(BR㸫1000㸪す⃝㟁ᶵィჾ〇సᡤ)ࢆ⏝࠸㸪 ᐃ㒊఩ࡣྑഃည➽㒊࡜ࡋࡓ㸬ィ ࡣ࢖࣋ࣥࢺ
ᅇᩘ㸪⥲ညࡳࡋࡵ᫬㛫࡜ࡋࡓ㸬㸰㸧デ᩿⏝ࢫࣉࣜࣥࢺ
デ᩿⏝ࢫࣉࣜࣥࢺࡣ㸪๓ᅇࡢሗ࿌࡜ྠᵝ࡟ୖୗ࢔ࣝࢪࢿ࣮ࢺ༳㇟ᮦ࡟࡚༳㇟᥇ᚓᚋ㸪⮻ṑ㒊࡛ 3mm
ᣲୖࡋࡓୗ㢡఩࡟࡚ညྜ᥇ᚓ㸪సᴗ⏝ᶍᆺ〇స㸪༙ㄪ⠇ᛶညྜჾ࡟࡚〇సࡋࡓ㸬ḟ࡟㸪0.75mm ࡢ࣏࢚ࣜࢫࢸࣝࢩ࣮ࢺ㸦DURAN㸪ࢪࣙ࢖ࢹࣥࢱࣝ㸧ࢆᡂᆺჾ㸦࣑ࢽࢫࢱ࣮Sscan㸪ࢪࣙ࢖ࢹࣥࢱࣝ㸧࡟ࡼࡾᅽ᥋㸪ࢺ࣑ࣜࣥࢢᚋ㸪ညྜ㠃࡟ 1㹼1.5mm ⛬ᗘࡢࢡࣜ࢔ࣛࣥࢫࢆ☜ಖ࡛ࡁࡿࡼ࠺ㄪᩚ㸪༶᫬㔜ྜࣞࢪࣥ㸦ࣇ࢓ࢭࢵࢺࣞࢪࣥ㸪GC㸧࡟ṑ㠃◊☻๣㸦࢚࢔ࣇ࣮ࣟࣃ࢘ࢲ࣮㸪ᯇ㢼㸧ࢆΰྜࡋ㸪ညྜ㠃࡟⠏┒ᚋ㸪ࣇࣝࣂࣛࣥࢫ࣭࢜ࢡ࣮ࣝࢪࣙࣥࢆ௜୚ࡋࡓ 2)㸬
 㸱㸧ည⪖㔞ࡢホ౯ည⪖㔞ࡢホ౯ࡣ㸪౑⏝๓㸪7㸪14 ᪥㛫౑⏝ࡋࡓデ᩿⏝ࢫࣉࣜࣥࢺࢆࢩࣜࢥ࣮ࣥ༳㇟ᚋ㸪㉸◳▼⭯࡟࡚〇సᚋ㸪୕ḟඖᙧ≧ ᐃ⿦⨨(Optorace2㸪ᯇ㢼)ࢆ⏝࠸࡚୕ḟඖ෌ᵓᡂീࢆసᡂࡋ㸪VRMeshc3.5Studio
(VirtualGrid Company)࡟࡚᭱ᑠ஧஌ἲࢆ⏝࠸࡚ࣞࢪࢫࢺ࣮ࣞࢩࣙࣥᚋ㸪ࡑࡢኚ໬㔞࡜ࡋ࡚ Amira5.2.0
(Visage Imaging, Inc)ࢆ⏝࠸య✚࡜ࡋ࡚⟬ฟࡋࡓ㸬

ᅗ1㸬ᕥ㸸᏶ᡂࡋࡓࣈࣛ࢟ࢩࢬ࣒ ᐃ⏝ࢫࣉࣜࣥࢺ㸬ྑ㸸୕ḟඖࣔࢹࣝࡢ⿦╔๓ᚋ㔜ࡡ࠶ࢃࡏ⏬ീ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᐇ㦂ᮇ㛫୰࡟ྠពࡀᚓࡽࢀࡓᝈ⪅ࡣ5⑕౛࡛㸪⏨ᛶ3ྡ㸪ዪᛶ2ྡ㸪28ṓ࠿ࡽ45ṓ࡛ᖹᆒᖺ㱋ࡣ34.5ṓ
࡛࠶ࡗࡓ㸬ࢫࣉࣜࣥࢺ⿦╔๓ᚋࡢࣈࣛ࢟ࢩࢬ࣒࢖
࣋ࣥࢺᅇᩘࡣ࡯ࡰኚ໬࡞ࡃ㸪ညࡳࡋࡵ᫬㛫ࡣ⿦╔๓࡟ẚ㍑ࡋ⿦╔ᚋ࡟ῶᑡഴྥ࡛࠶ࡗࡓ㸬ࢫࣉࣜࣥࢺࡢည⪖㔞ࡢᖹᆒࡣ8.98±7.89mm3 ࡛㸪๓ṑ㒊࡜ẚ
㍑ࡋ⮻ṑ㒊ࡢည⪖㔞ࡀከ࠸ഴྥࡀఛ࠼ࡓ㸬ࣈࣛ࢟ࢩࢬ࣒⮬ぬᝈ⪅⩌ࡢ1᫬㛫࠶ࡓࡾࡢᖹᆒ࢖࣋ࣥࢺᅇ
ᩘࡣ7.31±3.95ᅇ㸪1᫬㛫࠶ࡓࡾࡢᖹᆒညࡳࡋࡵ᫬㛫
ࡣ240.30±303.53⛊࡛࠶ࡗࡓ㸬೺ᖖ⪅࡜ẚ㍑ࡋ㸪ည⪖㔞㸪ࣈࣛ࢟ࢩࢬ࣒ࡢ࢖࣋ࣥࢺᅇᩘ㸪ညࡳࡋࡵ᫬
㛫ࡢ඲࡚࡟࠾࠸࡚ቑຍࡋ࡚࠸ࡓ㸬ϫ㸬 ᩥ⊩1) Simon J. Biomechanically-induced dental desease.
GenDent 48㸸598-605, 2000㸬
2) Ỉ㔝㉳Ⰻᘅ ည㢌ᔐྜ఩௜㏆ࡢ࿪ᄮ㐠ື⤒㊰࡟㛵ࡍࡿ◊✲㸬ឡ㝔኱ṑㄅ㸪17㸸259-283㸪1980㸬

− 150 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 20╧╀᫬ࣈࣛ࢟ࢩࢬ࣒⮫ᗋデ᩿ᇶ‽ࡢ᳨ド̾➽άືࣃࢱ࣮ࣥ࡜⮫ᗋᚩೃࡢ㛵㐃̾‫⿱⏣ྜྷۑ‬ဢ㸪ⵀ⃝⚽୍㑻㸪㓇஭ᣅ㑻㸪Ⳣ἟ᓅྐ㸪㧗ሙ㞞அ㸪ᑠ㔝ᗣᐶ㸪Ᏻ㒊཭ె㸪 ྜྷ⃝ள▮Ꮚ㸪୰ᮧᾈᓫ㸪ᕝྡࡩࡉỤ*㸪㤿ሙ୍⨾᫛࿴኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫㅮᗙ㸪 *ࡺࡳࡢࣁ࣮ࢺࢡࣜࢽࢵࢡ
Evaluation of clinical diagnostic criteria for sleep bruxism- Association between EMG activity pattern and clinical signs and symptoms Yoshida Y, Yoshizawa S, Sakai T, Suganuma T, Takaba M, Ono Y, Abe Y, Yoshizawa A, Nakamura H,
Kawana F*, Baba K
Department of Prosthodontics, School of Dentistry, Showa University, * Yumino Heart ClinicϨ㸬 ┠ⓗ ╧╀᫬ࣈࣛ࢟ࢩࢬ࣒(SB)ࡢ⮫ᗋデ᩿ࡣ㸪╧╀ྠక⪅࡟ࡼࡿṑࡂࡋࡾ㡢ࡢᣦ᦬㸪ည⪖㸪㉳ᗋ᫬⑕≧㸪ည➽⫧኱➼ࡢ⮫ᗋᚩೃࢆᇶ࡟ࡋ࡚⾜ࢃࢀࡿࡀ1)㸪ည⪖࡜SBࣞ࣋ࣝ࡜ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚ྰᐃⓗ࡞ሗ࿌ࡶ࠶ࡾ㸪ࡇࢀࡽࡢデ᩿ᇶ‽ࡢጇᙜᛶࡣᮍࡔᐇドࡉࢀ࡚࠸࡞࠸㸬ࡑࡢཎᅉ࡜ࡋ࡚SBࡢⓎ⑕࡟㛵ࢃࡿᅉᏊ㸪⾲⌧ᆺ࡜ࡶ࡟ከᵝ࡛࠶ࡿࡀ㸪ࡑࢀࡽࡀ୍ᣓࡾ࡟ࡉ
ࢀ࡚ࡁࡓࡇ࡜ࡀᣲࡆࡽࢀࡿ㸬౛࠼ࡤSB episodeࢆ㐠ືㄽⓗ࡟ᤊ࠼ࡿ࡜㸪ᑡ࡞ࡃ࡜ࡶclenching㸪grinding㸪୧⪅ࡢΰྜᆺࡀ࠶ࡾ㸪ࡑࢀࡒࢀࡢከᐻࡀ␗࡞ࡿ⮫ᗋᚩೃࢆつᐃࡍࡿྍ⬟ᛶࡀ㧗࠸㸬஦ᐇ㸪๓㏙ࡢည
⪖࡟ࡘ࠸࡚ࡣ㸪SB episodeࢆtonic࡜phasic࡟ศࡅ࡚ศ ᯒ ࡋ ࡓ ◊ ✲ ࡟ ࡼ ࡾ 㸪 grinding ࢆ ཯ ᫎ ࡍ ࡿ phasic
episode࡜ࡢ㛵㐃ᛶࡀ♧၀ࡉࢀ࡚࠸ࡿ1)㸬
 ௨ୖࡢ⫼ᬒࡼࡾᮏ◊✲࡛ࡣ㸪๓㏙ࡢ⮫ᗋデ᩿ᇶ‽ࡢጇᙜᛶࢆ᳨ドࡍࡿࡇ࡜ࢆ┠ⓗ࡟㸪SBࣜࢫࢡᅉᏊࡸ㛵㐃⑌ᝈࡢ࡞࠸୍ḟᛶSBᝈ⪅ࢆᑐ㇟࡜ࡋ࡚㸪SB episodeࢆtonic࡜phasic࡜࡟ศ㢮ࡋ㸪ྛ⮫ᗋᚩೃ࡜ࡢ㛵㐃ᛶࢆ᳨ウࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣ⚄⤒⑌ᝈ㸪⢭⚄㞀ᐖ㸪╧╀㞀ᐖ㸪ᖖ⏝⸆ࡢ࡞࠸೺ᖖᡂே࡜ࡋ㸪⮫ᗋデ᩿ᇶ‽(㐣ཤ6ࣨ᭶
࡟㐌3ኪ௨ୖࡢ╧╀ྠక⪅࡟ࡼࡿṑࡂࡋࡾ㡢ࡢᣦ᦬㸪
10ṑ௨ୖࡢ㇟∳㉁࡟ཬࡪည⪖㸪㉳ᗋ᫬ࡢ࿪ᄮ➽⑂ປឤࡢ࠺ࡕ2ࡘ௨ୖࢆ‶ࡓࡍ)ࢆ⏝࠸࡚SB⩌21ྡ(ᖹᆒᖺ㱋26.7s2.7ṓ㸪ዪᛶ52.4%)࡜Control⩌14ྡ(ᖹᆒᖺ㱋24.5s2.8ṓ㸪ዪᛶ50.0%)ࢆືဨࡋࡓ㸬SBࡢ☜ᐃデ᩿ࡢࡓࡵ࡟㸪ࡍ࡭࡚ࡢ⿕㦂⪅ࢆᑐ㇟࡟ည➽➽㟁ᅗࢆྵࡴPSG᳨ᰝࢆ2ኪᐇ᪋ࡋࡓ㸬2ኪ┠ࡢᐃࢹ࣮ࢱࢆ⏝࠸࡚SBࡢ☜ᐃデ᩿ࢆ⾜ࡗࡓ 2) 㸬╧╀ᵓ㐀ࡢゎᯒࡣ㸪American Academy of Sleep Medicineࡢ࢞࢖ࢻࣛ࢖ࣥ(2007)࡟‽ᣐࡋ࡚⾜࠸㸪SBデ᩿ᇶ‽2)ࢆࡶ࡜࡟ྠᐃࡋࡓSB episodeࢆphasic㸪mixed㸪
tonic ࡢ3ࢱ࢖ࣉ࡟ศ㢮ࡋ㸪ࡉࡽ࡟mixed episode࡟ࡘ࠸࡚ࡣphasic burst࡜tonic burst࡟ศࡅ㸪᭱⤊ⓗ࡟
phasic burst࡜tonic burstࡢ⥲ᣢ⥆᫬㛫ࢆ⟬ฟࡋࡓ㸬ࡲࡓ㸪ࣅࢹ࢜ࢹ࣮ࢱࢆཧ↷ࡋ࡚phasic episodeࡢ࠺ࡕṑࡂࡋࡾ㡢ࢆక࠺episodeࢆ࢝࢘ࣥࢺࡋࡓ㸬๓㏙

ࡢ╧╀ྠక⪅ࡢᣦ᦬㸪10ṑ௨ୖࡢ㇟∳㉁࡟ཬࡪည
⪖㸪㉳ᗋ᫬⑕≧࡟ࡘ࠸࡚㸪ࡑࢀࡒࢀࡢ᭷↓࡟ࡼࡾ
SB⩌ࢆ2⩌࡟ศࡅ㸪Control⩌࡜ྜࢃࡏࡇࢀࡽࡢኚ
ᩘ࡟ࡘ࠸࡚ẚ㍑᳨࣭ウࢆ⾜ࡗࡓ㸬(Kruskal-Wallis,
Steel-Dwass, p<0.05)Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ╧╀ᵓ㐀࡟ࡘ࠸࡚ࡣ㸪SB⩌࡛╧╀ຠ⋡ࡀపࡃ㸪╧╀ࢫࢸ࣮ࢪ2ࡢ๭ྜࡀ኱ࡁ࠸ഴྥࡀㄆࡵࡽࢀࡓࡀ㸪ṇᖖ⠊ᅖෆ࡛࠶ࡗࡓ㸬ࡲࡓ㸪phasic㸪tonic burst࡜ࡶ࡟SB⩌࡟࠾࠸࡚Control⩌ࡼࡾ᭷ព࡟㛗࠿ࡗࡓ㸬 ⮫ᗋᚩೃ࡟ࡼࡾSB⩌ࢆศࡅࡿ࡜㸪ည⪖⩌ࡣ㸪phasic burstࡢ⥲ᣢ⥆᫬㛫ࡀ᭷ព࡟㛗࠿ࡗࡓ㸬╧╀ྠక⪅ࡢᣦ᦬࡟ࡘ࠸࡚ࡣphasic burst࡟᭷ព࡞ᕪࡣ
ㄆࡵࡽࢀ࡞࠿ࡗࡓࡀ㸪ṑࡂࡋࡾ㡢ࢆక࠺episodeᩘࡀᣦ᦬ࡢ࠶ࡿ⩌࡛᭷ព࡟ከ࠿ࡗࡓ㸬㉳ᗋ᫬ࡢ࿪ᄮ
➽⑂ປឤ࡟ࡘ࠸࡚ࡣ⑕≧ࢆッ࠼ࡿ⩌ࡢtonic burstࡢ⥲ᣢ⥆᫬㛫ࡀ᭷ព࡟㛗ࡃ㸪⑕≧ࡢ࡞࠸⩌ࡣControl⩌࡜ྠ⛬ᗘ࡛࠶ࡗࡓ(⾲)㸬
 ௨ୖࡼࡾ㸪ည⪖࡜╧╀ྠక⪅ࡢᣦ᦬ࡣ㸪ࡑࢀࡒࢀphasic࡞άື࡜㡢ࢆక࠺phasic࡞άືࢆ㸪㉳ᗋ᫬ࡢ࿪ᄮ➽⑂ປឤࡣ㸪clenchingࢆ཯ᫎࡍࡿtonic࡞άື࡜㛵㐃࡙ࡅࡽࢀ㸪ྛデ᩿ᇶ‽ࡀ␗࡞ࡿSB episodeࢆ཯ᫎࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ᮏ◊✲⤖ᯝࡣ㸪SB
ࡢ⑕ᆺศ㢮࡜ࡑࢀ࡟ᑐᛂࡋࡓデ᩿ᇶ‽ࢆ⟇ᐃࡍࡿୖ࡛᭷⏝࡞ᇶ┙ࢹ࣮ࢱ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿ㸬 ⮫ᗋᚩೃ࡜➽άືࣃࢱ࣮ࣥࡢ㛵ಀ⮫ᗋᚩೃSB burst
ࡢ✀㢮SB⩌
1: ᚩೃ᭷
2: ᚩೃ↓

᭷ពᕪ
p<0.05ည⪖phasic295.7 ±168.7

113.7 ±46.8

19.4 ±18.3 1vs2, 2vs3,1vs3

ྠక⪅ᣦ᦬phasic223.4 ±147.8

109.0 ±76.1

19.4 ±18.3

2vs3, 1vs3

㉳ᗋ᫬⑕≧

tonic

58.5 ± 34.1

29.3 ±22.5

11.7 ±12.4(sec)

1vs2, 1vs3

ϫ㸬 ᩥ⊩

− 151 −

3: Control⩌

1)

2)

Yoshizawa S, Suganma T, Takaba M, Ono Y,
SakaiT, Yoshizawa A et al. Phasic jaw motor
episodes in healthy subjects with or withoutclinical signs and symptoms of sleep bruxism: apilot study. Sleep Breath. 2014㸹18㸸187-93.
Lavigne GJ, Rompre P, Montplasisir J, Sleep
bruxism: validity of clinical research diagnostic
criteria in a controlled polysomnographic study. J
Dent Res. 1996㸹75㸸546-52.

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一般口演発表1 ─ 3 ─ 21

CCN4/WISP1ࡣWntࢩࢢࢼࣝ⤒㊰ࢆ௓ࡋ࡚㦵ࡢࣜࣔࢹࣜࣥࢢ
ࢆไᚚࡍࡿ‫ۑ‬๓⏣࠶ࡎࡉ*,**㸪኱㔝඘᫛*㸪❑ᮌᣅ⏨*㸪Marian F. Young***ᒸᒣ኱Ꮫ኱Ꮫ㝔་ṑ⸆Ꮫ⥲ྜ◊✲⛉࢖ࣥࣉࣛࣥࢺ෌⏕⿵⥛Ꮫศ㔝㸪**National Instituteof Dental and Craniofacial Research, National Institutes of Health (NIH)
CCN4/WISP1: Potential Regulator of Mineralized Tissue through Modulation of Wnt Signaling
Maeda A*,**, Ono M*, Kuboki T*, Young MF**
*Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School,**National Institute of Dental and Craniofacial Research, National Institutes of Health (NIH)Ϩ㸬 ┠ⓗ㧗ᗘ࡞㦵྾཰ࡣ⿵⥛ṑ⛉ศ㔝࡟࠾࠸࡚㞴⑕౛ࢆ⏕ࡳฟࡍせᅉࡢ୍ࡘ࡛࠶ࡾ㸪㦵ⱆ⣽⬊㸪◚㦵⣽⬊ศ໬ไᚚ࣓࢝ࢽࢬ࣒ࡢ⌮ゎࡀᚲせ୙ྍḞ࡛࠶ࡿ㸬
CCN ࣇ ࢓ ࣑ ࣜ ࣮ ࡟ ᒓ ࡍ ࡿ ศ Ἢ ࢱ ࣥ ࣃ ࢡ ㉁ CCN
family 4/Wnt-induced secreted protein 1 (௨ୗCCN4)ࡣ㦵⤌⧊ࡢⓎ⏕㐣⛬࡞ࡽࡧ࡟㦵ᢡ἞⒵㐣⛬࡟࠾࠸࡚㧗Ⓨ⌧ࡋ࡚࠸ࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀ1)㸪㦵ࣜࣔࢹࣜࣥࢢ࡟࠾ࡅࡿࡑࡢᶵ⬟ࡣᮍࡔ༑ศ࡟᫂ࡽ࠿
࡟ࡉࢀ࡚࠸࡞࠸㸬ᮏ◊✲࡛ࡣin vivoࡢ㦵௦ㅰ࡟࠾
ࡅࡿCCN4ࡢᶵ⬟ࢆ᫂ࡽ࠿࡟ࡋࡓࡢ࡛ሗ࿌ࡍࡿ㸬ϩ㸬 ᪉ἲ඲࡚ࡢື≀ᐇ㦂ࡣNIHື≀ᐇ㦂೔⌮ᑂᰝጤဨ఍
ࡢᢎㄆࡢࡶ࡜ᐇ᪋ࡋࡓ㸬඲㌟ᛶCcn4Ḟᦆ࣐࢘ࢫ(Ccn4-KO)ࢆస〇ࡋ㸪1, 3, 9ࣨ᭶㱋࣐࢘ࢫ࠾ࡼࡧ༸
ᕢ᦬ฟࢆ⾜ࡗࡓ6ࣨ᭶㱋࣐࢘ࢫࡢ඲㌟㦵ᐦᗘࢆDXA
ἲ࡟࡚㸪ࡲࡓ3ࣨ᭶㱋ࡢ࣐࢘ࢫ኱⭣㦵㦵ᐦᗘࢆ࣐࢖
ࢡࣟCT (μCT)ࢆ⏝࠸࡚ゎᯒࡋࡓ㸬8㐌㱋ࡢ࣐࢘ࢫ࡟
࢝ࣝࢭ࢖ࣥ/ࢸࢺࣛࢧ࢖ࢡࣜࣥࢆ12᪥㛫㝸࡛⭡⭍ෆᢞ୚㸪ᶞ⬡ໟᇙ⤌⧊ษ∦࡟࡚⺯ග஧㔜ᶆ㆑ࡢ㛫㝸ࢆィ ࡋ㸪▼⅊໬㏿ᗘࢆホ౯ࡋࡓ㸬
CCN4ࡀ㦵ⱆ⣽⬊ศ໬࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ㸪࣐࢘ࢫᚋ⫥࠿ࡽ㦵㧊⏤᮶㛫ⴥ⣔㛫㉁⣽⬊(mBMSCs)ࢆ᥇ྲྀࡋࡓ㸬㦵ⱆ⣽⬊ศ໬ㄏᑟᇵᆅ࡛ᇵ
㣴ࡋ㸪࢔ࣜࢨࣜࣥࣞࢵࢻᰁⰍࢆ⾜࠺࡜࡜ࡶ࡟㸪⣽⬊୰ࡢ㦵㛵㐃㑇ఏᏊ(Alp, Ocn, Bsp)࡞ࡽࡧ࡟Wntࢩࢢࢼࣝ㛵㐃㑇ఏᏊ(Axin2, Ccnd1)ࡢmRNAⓎ⌧ࣞ࣋ࣝࢆᐃ㔞ᛶRT-PCRἲ࡟࡚ホ౯ࡋࡓ㸬◚㦵⣽⬊ศ໬࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ㸪ྠᵝࡢ㦵㧊࠿ࡽ᥇ྲྀࡋࡓ㠀᥋╔⣽⬊ࢆRANKL㸪M-CSF่⃭ୗ࡟࡚ᇵ㣴ࡋ㸪TRAPᰁⰍ࡟࡚ホ౯ࡋࡓ㸬ࡉࡽ࡟㸪mBMSCs
ࢆࢮࣛࢳࣥࢫ࣏ࣥࢪ࡜ඹ࡟ච␿୙඲࣐࢘ࢫࡢ⫼㒊⓶ୗ࡟⛣᳜ࡋ㸪6㐌㛫ᚋ࡟⛣᳜∦ࢆᅇ཰ࡋࡓ㸬μCT᧜ᙳᚋ࡟⤌⧊Ꮫษ∦ࢆస〇ࡋ㸪H&EᰁⰍ㸪ࣆࢡࣟࢩࣜ࢘ࢫࣞࢵࢻᰁⰍ࠾ࡼࡧTRAPᰁⰍ࡟࡚㸪㦵ᙧᡂ㔞࠾ࡼࡧ㦵ⱆ⣽⬊㸪◚㦵⣽⬊ᙧᡂ⬟ࢆホ౯ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ㔝⏕ᆺ࣐࢘ࢫ(WT)࡜ẚ㍑ࡋ㸪Ccn4-KO࡛ࡣ⏕ᚋ3ࣨ᭶ࡼࡾ඲㌟㦵ᐦᗘࡀపୗࡋ㸪ࡑࡢ⾲⌧ᆺࡣ㞤ࡢ᪉ࡀᙉ࠸ഴྥࢆ♧ࡋࡓ㸬ࡲࡓ㸪༸ᕢ᦬ฟ࣭㦵⢒㧼⑕ࣔࢹࣝ࡟࠾࠸࡚ࡑࡢ⾲⌧ᆺࡣቑ኱ࡋࡓ㸬μCTゎᯒࡢ⤖ᯝ㸪3ࣨ᭶㱋㞤ࡢCcn4-KO࡟࠾࠸࡚㸪ᾏ⥥㦵㦵ᐦᗘ㸪㦵ᱱᩘ㸪㦵ᖿ᩿㠃✚࡞ࡽࡧ࡟⓶㉁㦵ࡢཌࡳࡣ᭷ព࡟ప࠿ࡗࡓ(ᅗA)㸬ࡲࡓ㸪Ccn4-KOࡢ⓶㉁㦵ࡢ▼⅊໬㏿ᗘࡣ᭷ព࡟పୗࡋ࡚࠸ࡓ㸬in vitro࡟࠾࠸࡚㸪Ccn4-KO⏤᮶BMSCsࡢ㦵ⱆ⣽⬊ศ໬⬟ࡣ᭷ព࡟పୗࡋ࡚࠸ࡓ(ᅗB)㸬୍᪉㸪◚㦵⣽⬊ศ໬⬟ࡣCcn4-KO⏤᮶⣽⬊࡟࠾࠸࡚ಁ㐍ࡋ࡚࠸ࡓ(ᅗC)㸬ࡲࡓ㸪mBMSCs⫼㒊⛣᳜ᐇ㦂ࡢ⤖ᯝࡶྠᵝ㸪Ccn4-KO⏤᮶BMSCs⛣᳜⩌࡟࠾࠸࡚◳⤌⧊ᙧᡂࡢᢚไ㸪㦵ⱆ⣽⬊ᩘࡢῶᑡ㸪TRAP㝧ᛶ◚㦵⣽⬊ࡢቑຍࡀㄆࡵࡽࢀࡓ㸬ࡲࡓ㦵ⱆ⣽⬊ศ໬㐣⛬࡟࠾࠸࡚㸪Ccn4-KO⏤᮶BMSCsࡢWntࢩࢢࢼࣝ㛵㐃㑇ఏᏊࡢmRNAⓎ⌧ࣞ࣋ࣝࡣ᭷ព࡟పୗࡋ࡚࠸ࡓ㸬௨ୖࡢ⤖ᯝࡼࡾ㸪CCN4ࡣ㦵ⱆ⣽⬊㸪◚㦵⣽⬊ศ໬ࢆㄪᩚࡍࡿࡇ࡜࡛㸪㦵ࡢࣜࣔࢹࣜࣥࢢࢆไᚚࡋ
࡚࠸ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ㸬ࡲࡓ㸪Wntࢩࢢࢼࣝ⤒㊰ࡢୗὶ࡟఩⨨ࡍࡿCCN4ࡀྠࢩࢢࢼࣝ⤒㊰ࡢㄪ⠇࡟㛵୚ࡋ࡚࠸ࡿྍ⬟ᛶࡀ♧ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) French DM, Kaul RJ, D'Souza AL, Crowley CW,
Bao M, Desnoyers L et al. WISP-1 is an osteoblastic
regulator expressed during skeletal development
and fracture repair. Am J Pathol 2004; 165 (3):855867− 152 −

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S-PRG fillerࢆྵ᭷ࡍࡿ⩏ṑ⏝PMMAࡢCandida albicansቑṪᢚไຠᯝ‫ۑ‬ሐ༓᫂㸪ⱝᯘ๎ᖾᅜ❧኱Ꮫἲேᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔 㒊ศᗋ⩏ṑ⿵⥛Ꮫศ㔝Effect of S-PRG filler content on  biofilms retention in PMMA denture base resin.
Tsutsumi C, Wakabayashi N
Removable Partial Prosthodontics, Graduate School, Tokyo Medical and Dental University (TMDU)Ϩ㸬 ┠ⓗ⩏ṑᛶཱྀෆ⅖ࡢ୺せ࡞⑓ᅉࡢ୍ࡘ࡜ࡋ࡚   ࡢ⩏ṑ࡬ࡢ௜╔ࡀᣲࡆࡽࢀ࡚࠾ࡾ㸪ࡇࢀࢆ㝖ཤࡍࡿࡇ࡜ࡀண㜵࠾ࡼࡧ἞⒪࡟᭷ຠ࡛࠶ࡿ 1) 㸬
Surface reaction-type pre-reacted glass ionomer 㸦 SPRG㸧fillerࡣࣇࢵ໬≀ࢆྵࡴ6✀㢮ࡢ࢖࣮࢜ࣥࣜࣜ
ࢫ࡜ࣜࢳ࣮ࣕࢪᶵ⬟ࢆ᭷ࡍࡿࣂ࢖࣐࢜ࢸࣜ࢔࡛ࣝ࠶ࡾ㸪  ࡞࡝ࡢ࠺⼃ࡢཎᅉ⳦࡟ᢠ⳦ᛶࢆ♧ࡍࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗ࡚࠸ࡿ2)㸬ᮏ◊✲࡛ࡣ㸪᪂ࡓ࡟ྠࣇ࢕࣮ࣛࢆ⩏ṑᗋ⏝࣏࣐࣮࡛ࣜ࠶ࡿPMMAࣞࢪࣥ࡟ῧຍࡋࡓᐇ㦂ⓗ⩏ṑᗋヨᩱࢆ⏝࠸㸪ᇵ㣴ࡋࡓ   ࡢ௜╔࡟ࡘ࠸࡚ᐇ㦂ⓗ࡟᳨ウࡋࡓ㸬ϩ㸬 ᪉ἲᐇ㦂࡟ࡣ    JCM2085 ᰴࢆ⏝࠸ࡓ㸬S-PRG
filler㸦ᯇ㢼㸧ࢆࡑࢀࡒࢀ 0%㸪5%, 10㸣㸪20%㸦㔜
㔞%㸧ྵ᭷ࡍࡿ PMMA ࣏࣐࣮ࣜ㸦URBAN㸪ᯇ㢼㸧ࢆ 10g ࡟ᑐࡋ࡚ MMA ࣔࣀ࣐࣮5ml ࡢ๭ྜ࡛ᐜჾ୰
࡟࠾࠸࡚ΰ࿴ࡋ㸪㏻ἲ㏻ࡾຍ⇕㔜ྜࢆ⾜ࡗ࡚ࣞࢪࣥ
ࢹ࢕ࢫࢡ㸦┤ᚄ 10 mm㸪ཌࡉ 2 mm㸧ࢆ〇సࡋࡓ㸬ࢹ࢕ࢫࢡ࠿ࡽࡢ⤒᫬ⓗ࡞࢖࣮࢜ࣥࣜࣜࢫ㔞ࡣࣇࢵ⣲」ྜ㟁ᴟ㸦9609BNWP㸪࢜ࣜ࢜ࣥ㸧࡜ ICP Ⓨගศᯒ⿦⨨㸦ICPS-8000㸪ᓥὠ〇సᡤ㸧࡛ 24 ᫬㛫 ᐃࡋࡓ㸬㓝ẕᆺ    ࡀ 104cell/ml ධࡿࡼ࠺࡟ㄪ⠇ࡋࡓ
YPD ᇵᆅ࡜ 24 ࢙࢘ࣝࣉ࣮ࣞࢺࢆ⏝࠸㸪ᐇ㦂ᐊ࡛ㄪᩚࡋࡓேᕤၚᾮ࡛ฎ⌮ࡋࡓࢹ࢕ࢫࢡୖ࡛   
ࢆ 37Υ㸪16 ᫬㛫ᇵ㣴ࡋࡓ㸬ࢥࣥࢺ࣮ࣟࣝ࡜ࡋ࡚YPD ᇵᆅࡢࡳࡢ᥋✀ࡶ⾜ࡗࡓ㸬ᇵ㣴ᚋ㸪Phosphatebuffered saline ࡛ 2 ᅇὙίࡋࡓᚋ㸪ࢡࣜࢫࢱࣝࣂ࢖࢜
ࣞࢵࢺᰁⰍ㸪XTT assay ࡢᚋ࣐࢖ࢡࣟࣉ࣮ࣞࢺ࣮ࣜ
ࢲ࣮࡛྾ගᗘ ᐃ㸦OD450nm㸧ࢆ⾜࠸    ࡢቑṪࢆホ౯ࡋࡓ㸬ࡉࡽ࡟ࣞࢪࣥࢹ࢕ࢫࢡୖ࡛ᇵ㣴୰ࡢ⳦ࡢኚ໬ࢆ SEM ࡛ほᐹࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᰁⰍࡢ⤖ᯝࡼࡾ㸪࡝ࡢࢹ࢕ࢫࢡ࡟ࡶ   ࡢ௜╔ࡀ⫗║࡛ぢࡽࢀࡓࡀfillerྵ᭷⋡0%࡛ࡣࡑࡢ௜
╔ࡀከ࠸ഴྥࡀ࠶ࡗࡓ㸬ࡲࡓ㸪XTT assayࡢ⤖ᯝࡼࡾfillerࡢྵ᭷㔞ࡢቑຍ࡟క࠸྾ගᗘࡣῶᑡࡋࡓࡀ

fillerࢆྵ᭷ࡍࡿ⩌㛫࡛ࡣ⤫ィᏛⓗ࡟᭷ពᕪࡣぢࡽࢀ࡞࠿ࡗࡓ㸦ᅗ㸧㸬YPDᇵᆅࡢࡳࢆ᥋✀ࡋࡓ⩌ࡣ㸪
fillerྵ᭷⋡࡟ࡼࡽࡎ྾ගᗘࡀప࠿ࡗࡓࡇ࡜࠿ࡽ   ࢆ᥋✀ࡋࡓ⩌ࡢ⤖ᯝࡣ   ࡀቑṪࡋ࡚࠸ࡿࡇ࡜ࡀ☜ㄆࡉࢀࡓ㸬SEM⏬ീࡢ⤖ᯝࡼࡾ
fillerྵ᭷⋡0%࡛ࡣ᫬㛫ࢆ㏣࠺ࡈ࡜࡟⑓ཎᛶࡢ㧗࠸⳦⣒ᆺࡀከࡃほᐹࡉࢀࡿ୍᪉࡛㸪fillerࢆྵ᭷ࡍࡿ
ࢹ࢕ࢫࢡ࡛ࡣ⳦⣒ᆺࡢቑṪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬ᅗ㸬XTT assay ᚋࡢ྾ගᗘ
௨ୖࡢ⤖ᯝࡼࡾ㸪S-PRG filler ྵ᭷ PMMA ࣞࢪࣥࡢ౑⏝࡟ࡼࡾ⩏ṑᗋࣞࢪࣥ⾲㠃ࡢ    ࡢቑṪࢆᢚไࡍࡿຠᯝࡢྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) Redding S, Bhatt B, Rawls HR et al.:Inhibitionof Candida albicans biofilm formation on denturematerial. Oral Surg Oral Med Oral Pathol Oral
Radiol Endod. 2009;107(5):669-72.
2) Saku S, Kotake H, Scougall-Vilchis RJ et al.:Antibacterial activity of composite resin withglass-ionomer filler particles. Dent Mater J
2010;29(2):193–198.

− 153 −

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一般口演発表1 ─ 3 ─ 23㐣㓟໬Ỉ⣲ගศゎẅ⳦ᢏ⾡࡟࠾ࡅࡿගࡢἼ㛗࡜㐣㓟໬Ỉ⣲⃰ᗘࡢ┦஌స⏝‫ۑ‬၈ᮌಇⱥ㸪಴ෆ⨾ᬛᏊ㸪Ⳣ㔝ኴ㑻㸪຾⏣ᝆ௓㸪⊦㣫⣫௦㸪ᯘ ᰤᡂ㸪బࠎᮌၨ୍*㸪 Ụⲡ ᏹᮾ໭኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ ศᏊ࣭෌⏕ṑ⛉⿵⥛Ꮫศ㔝㸪*ཱྀ⭍ࢩࢫࢸ࣒⿵⥛Ꮫศ㔝
Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity ofphotolysis of H2O2
Toki T, Kurauchi M, Kanno T, Katsuda Y, Ikai H, Hayashi E, Sasaki K*, Egusa H
Division of Molecular and Regenerative Prosthodontics, *Division of Advanced Prosthetic Dentistry,
Tohoku University Graduate School of DentistryϨ㸬 ┠ⓗ ᡃࠎࡣ㸪㐣㓟໬Ỉ⣲㸦H2O2㸧࡟Ἴ㛗400 nmࡢගࢆ↷ᑕࡍࡿࡇ࡜࡛⏕ᡂࡉࢀࡿࣄࢻࣟ࢟ࢩࣛࢪ࢝ࣝ
㸦࣭OH㸧ࢆᛂ⏝ࡋࡓ㐣㓟໬Ỉ⣲ගศゎẅ⳦ᢏ⾡ࡢ◊✲ࢆ⾜ࡗ࡚ࡁࡓ㸬ࡇࢀࡲ࡛ࡢ◊✲࠿ࡽ㸪ᮏẅ⳦ἲࡢάᛶࡣ㸪H2O2⃰ᗘ㸪ගࡢᨺᑕ↷ᗘ㸪↷ᑕ᫬㛫࡟኱ࡁࡃ౫Ꮡࡍࡿࡇ࡜ࡀศ࠿ࡗ࡚࠸ࡿ㸬ᮏ◊✲࡛ࡣ㸪ගࡢἼ㛗࠾ࡼࡧH2O2⃰ᗘࢆኚ໬ࡉࡏࡓሙྜ࡟㸪୧⪅ࡢ┦஫స⏝ࡀ࣭OH⏕ᡂ཯ᛂ࡜ࡑࢀ࡟క࠺ẅ⳦άᛶ࡟ཬࡰࡍᙳ㡪ࢆホ౯ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ග※࡟ࡣ㸪Ἴ㛗365㸪385㸪400 nmࡢLEDࢫ࣏ࢵࢺ ◳ ໬ ࢩ ࢫ ࢸ ࣒ 㸦 OmniCure LX400+ 㸪 Lumen
Dynamics Group㸧࠾ࡼࡧἼ㛗465 nmࡢṑ⛉⏝LED↷ ᑕ ჾ 㸦 G-Light Prima-II, GC 㸧 ࢆ ᨺ ᑕ ↷ ᗘ 1000
mW/cm2࡛⏝࠸ࡓ㸬H2O2 ࡣ᭱⤊⃰ᗘ0㸪250㸪500㸪
1000 mM࡛⏝࠸ࡓ㸬H2O2ࡢගศゎ࡟ࡼࡗ࡚⏕ᡂࡉࢀࡿ࣭OHࢆ㟁Ꮚࢫࣆࣥඹ㬆ἲ࡟ࡼࡾᐃ㔞ศᯒࡋࡓ㸬ẅ⳦ヨ㦂࡟ࡣ㸪      JCM 2413ࢆ⏕⌮㣗ሷỈ࡟ᠱ⃮ࡋ࡚⏝࠸ࡓ㸬ึⓎ⳦ᩘࡀ3107
CFU/mL࡜࡞ࡿࡼ࠺࡟⣽⳦ᠱ⃮ᾮ࡜H2O2 ࡜ΰ࿴ࡋࡓヨᩱ࡟ᑐࡋ࡚LEDࢆ1ศ㛫↷ᑕࡋࡓ㸬LED↷ᑕᚋ࡟᥇ྲྀࡋࡓヨᩱࢆ࢝ࢱ࣮ࣛࢮ㸦5000 U/mL㸧࡜ΰ࿴ࡋ㐣㓟໬Ỉ⣲࡟ࡼࡿ཯ᛂࢆ೵Ṇࡋࡓ㸬ࡑࡢᚋ㸪
BHIᐮኳᇵᆅࢆ⏝࠸ࡓᇵ㣴ἲ࡟ࡼࡾヨᩱ୰ࡢṧᏑ⏕⳦ᩘࢆホ౯ࡋࡓ㸬ࢆㄆࡵࡓࡀ㸪385࠾ࡼࡧ400 nm࡛ࡣ2㹼3-log㸪465nm࡛ࡣ<1-log࡛࠶ࡗࡓ㸦ᅗ㸧㸬୍᪉㸪1ศ㛫ࡢH2O2
༢⊂ฎ⌮㸦LED↷ᑕ࡞ࡋ㸧࡛ࡣ⃰ᗘࡀ1000 mM࡛࠶ࡗ࡚ࡶẅ⳦ຠᯝࢆㄆࡵ࡞࠿ࡗࡓ㸬ࡲࡓ㸪LED↷ᑕ༢⊂㸦0 mM H2O2㸧ࡢሙྜ࡟ࡣ㸪365࠾ࡼࡧ385nm࡛ࢃࡎ࠿࡞㸦<1-log㸧ẅ⳦ຠᯝࢆㄆࡵࡓࡀ㸪400
࠾ࡼࡧ465 nm࡛ࡣࡑࡢຠᯝࡣㄆࡵ࡞࠿ࡗࡓ㸬 ගࡢἼ㛗࡜H2O2 ⃰ᗘࡢ┦஫స⏝ࡀ࣭OH ⏕ᡂ཯ᛂ࠾ࡼࡧẅ⳦άᛶ࡟ཬࡰࡍᙳ㡪ࢆ2ඖ㓄⨨ศᩓศᯒ᳨࡛ᐃࡋࡓ⤖ᯝ㸪୧⪅ࡣ┦஌ⓗ࡟ᙳ㡪ࢆཬࡰࡍࡇ
࡜ࡀ♧ࡉࢀࡓ㸬 ௨ୖࡢ⤖ᯝࡼࡾ㸪H2O2ගศゎẅ⳦ᢏ⾡࡟࠾࠸࡚㸪ගࡢἼ㛗࡜H2O2⃰ᗘࡢ⤌ࡳྜࡏ࡟ࡼࡾẅ⳦ຠᯝࡢቑᙉࡀྍ⬟࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ1)㸬௒ᚋ㸪ᮏᢏ⾡ࡢ⩏ṑࡸṑ⛉἞⒪ჾලࡢὙί㸪ࡉࡽ࡟ࡣṑ⛉ศ㔝࡟࠾ࡅࡿ⣽⳦ឤᰁ⑕἞⒪࡬ࡢᛂ⏝ࡀᮇᚅࡉࢀࡿ㸬

H2O2㸦500 mM㸧ࡢගศゎ㸦LED ↷ᑕ㸸365-465Ϫ㸬 ⤖ᯝ࡜⪃ᐹ H2O2 ࡟ᑐࡍࡿLED↷ᑕヨ㦂ࡢ⤖ᯝ㸪ගࡢἼ㛗ࡀ▷࠸࡯࡝㸪ࡲࡓH2O2⃰ᗘࡀ㧗࠸࡯࡝㸪࣭OHࡢ⏕ᡂ㔞ࡣቑຍࡋࡓ㸬࣭OH⏕ᡂ㔞࡜H2O2⃰ᗘ࡟ࡣ┤⥺ⓗ࡞┦㛵㛵ಀࢆㄆࡵࡓࡢ࡟ᑐࡋ࡚㸪࣭OH⏕ᡂ㔞࡜ගࡢἼ㛗࡟ࡣᣦᩘ㛵ᩘⓗ࡞┦㛵㛵ಀࢆㄆࡵࡓ㸬ࡇࢀࡣ㸪ගᏊ࢚ࢿࣝࢠ࣮ࡀἼ㛗࡟཯ẚ౛ࡍࡿࡇ࡜࡟㉳ᅉࡍࡿ࡜⪃࠼ࡽࢀࡿ㸬 ẅ⳦ヨ㦂ࡢ⤖ᯝ㸪H2O2 ⃰ᗘ࠾ࡼࡧගࡢἼ㛗࡟౫Ꮡࡋࡓẅ⳦άᛶࢆㄆࡵࡓ㸬500 mM H2O2࡟365 nm
ࡢLEDࢆ↷ᑕࡍࡿࡇ࡜࡛㸪5-log௨ୖࡢ⏕⳦ᩘῶᑡnm㸧࡟ࡼࡿẅ⳦స⏝ 1)
ㅰ㎡㸸ᮏ◊✲ࡣ㸪ᮾ໭኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉⏕య㐺ྜᛶィ ᕤᏛㅮᗙ ᗞ㔝ྜྷᕫᩍᤵ࡞ࡽࡧ࡟୰ᮧ
ᆂ♸ຓᩍࡢᚚᣦᑟࡢࡶ࡜⾜ࢃࢀࡓ㸬ϫ㸬 ᩥ⊩
1)Toki T et al. Synergistic interaction between
wavelength of light andconcentration of H2O2 inbactericidal activity of photolysis of H2O2. J
Biosci Bioeng 2015; 119: 358-362.

− 154 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 24㛗ᮇⓗணᚋࢆྍ⬟࡟ࡍࡿᢠ⳦ᛶṑ⛉⏝࢖ࢵࢺࣜ࢔Ᏻᐃ໬
ࢪࣝࢥࢽ࢔ᮦᩱࡢ㛤Ⓨ‫ۑ‬ᒣ⏣⌮Ἃ㸪㔝ᓮᾈభ*㸪᰿ᮏ᛭ዉ㸪ᒣୗோ኱**㸪୕ᾆᏹஅ㸪Ọ஭ளᕼᏊ*ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔 ་ṑᏛ⥲ྜ◊✲⛉ ᦤ㣗ᶵ⬟ಖᏑᏛศ㔝㸪ᮾி་⛉ṑ⛉኱Ꮫ⏕యᮦᩱᕤᏛ◊✲ᡤ *⏕యᮦᩱᶵ⬟་Ꮫศ㔝㸪**↓ᶵ⏕యᮦᩱᏛศ㔝
Fabrication of antibacterial yttria-stabilized zirconia for better prognosis
Yamada R㸪Nozaki K*㸪Nemoto R. Yamashita K**㸪Miura H㸪Nagai A*
Department of Fixed Prosthodontics, Graduate School of Medical and Dental Sciences, Tokyo Medical and
Dental University. *Department of Material Biofunctions, **Department of Inorganic Biomaterials, Instituteof Biomaterials and Bioengineering, Tokyo Medical and Dental University.

Ϩ㸬 ┠ⓗ࠺⼃ࡸṑ࿘⑌ᝈ➼࡟ࡼࡾṑ∳Ḟᦆࡀ⏕ࡌࡓሙྜ㸪⿵⥛⿦⨨࡟ࡼࡾᶵ⬟ࢆᅇ᚟ࡉࡏࡿ㸬ཱྀ⭍ෆ࡟⿵⥛⿦⨨ࢆ⿦╔ࡋࡓᚋ࡟㉳ࡇࡾ࠺ࡿၥ㢟Ⅼ࡟ࡣ㸪⿵⥛⿦⨨⾲㠃࡟ཱྀ⭍ෆ⣽⳦ࡢ௜╔㸪ࣉ࣮ࣛࢡࡢ⵳✚࡟㉳ᅉࡍࡿṑ࿘⑌ᝈࡢ⨯ᝈࡸ஧ḟ࠺⼃ࡀሗ࿌ࡉࢀ
࡚࠾ࡾ㸪⿵⥛⿦⨨ࡢ⬺㞳➼࡟ࡼࡿࠊ࿪ᄮᶵ⬟ࡸᑂ⨾ᛶࡢᝏ໬ࡀ⏕ࡌࡿ1㸧㸬ࡑࡢࡓࡵ㸪⿦╔ࡉࢀࡓ⿵⥛⿦⨨ࡢ㛗ᮇⓗணᚋࡢ☜❧ࡢࡓࡵ㸪⾡ᚋࡢឤᰁ㜵Ṇࡀྍ⬟࡞ᢠ⳦ᛶṑෙ⿵⥛⿦⨨ࡢᮦᩱ㛤Ⓨࡀᛴົ࡛࠶ࡿ㸬ᢠ⳦ຠᯝࢆ⏕యᮦᩱ࡟௜୚ࡍࡿⅭ࡟㸪ᢠ⳦ᛶࢆ᭷ࡍࡿ≀㉁ࢆ⏕యᮦᩱ࡟ᛂ⏝ࡍࡿᵝࠎ࡞ሗ࿌ࡀ
ࡉࢀ࡚࠸ࡿ㸬ᢠ⏕≀㉁࡞࡝ࡣ㸪ඃࢀࡓᢠ⳦ຠᯝࢆ
Ⓨ᥹ࡍࡿࡀ㸪ᚎᨺᮇ㛫ࡀ㝈ࡽࢀࡿࡇ࡜ࡸ⸆๣⪏ᛶ⳦ࡢฟ⌧➼ࡢၥ㢟Ⅼࡀ࠶ࡿ㸬↓ᶵ⣔ᢠ⳦≀㉁࡛࠶
ࡿ㖟ࡣ㸪ྂࡃ࠿ࡽࡑࡢ᭷⏝ᛶࡀሗ࿌ࡉࢀ࡚࠾ࡾ㸪ᵝࠎ࡞ṑ⛉ᮦᩱ࡬ࡢᛂ⏝ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪㏆ᖺ㸪ṑෙ⿵⥛⿦⨨⏝ᮦᩱ࡜ࡋ࡚ᖜᗈ
ࡃ⮫ᗋᛂ⏝ࡉࢀ࡚࠸ࡿ㸪࢖ࢵࢺࣜ࢔㒊ศᏳᐃᆺࢪ
ࣝࢥࢽ࢔(YSZ)࡬ࡢ㖟ࡢᛂ⏝ࡣᑡ࡞ࡃ㸪ࢳ࢙࢔ࢧ࢖ࢻ࡛ࡶ⡆౽࡟ࡑࡢຠᯝࢆ௜୚ࡍࡿ᪉ἲࡣሗ࿌
ࡉࢀ࡚࠸࡞࠸㸬ࡑࡇ࡛ᮏᐇ㦂࡛ࡣ㸪YSZ࡟ᢠ⳦ຠᯝࢆ௜୚ࡍࡿ
ࡇ࡜ࢆ┠ⓗ࡟㸪ᢠ⳦άᛶࢆ᭷ࡍࡿ✀ࠎࡢ⃰ᗘࡢ㖟࢖࢜ࣥ⁐ᾮࢆ⏝࠸࡚㸪YSZ࡟ࢥ࣮ࢸ࢕ࣥࢢࢆ᪋ࡋ㸪ࡑࡢ࢟ࣕࣛࢡࢱࣜࢮ࣮ࢩࣙࣥཬࡧᢠ⳦άᛶࡢホ౯ࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ
YSZࡢヨᩱ࡟ࡣࢪࣝࢥࢽ࢔⢊ᮎ㸦TZ-3YSB-E,ᮾ
ࢯ࣮㸧ࢆ౑⏝ࡋ୍㍈ຍᅽᡂᙧ࡟ࡼࡾᡂᙧయࢆస〇ᚋࠊ1450Υ㸪2᫬㛫↝ᡂࡋ↝⤖యࢆᚓࡓ㸬ᚓࡽࢀࡓ↝⤖యࢆ࢔ࢭࢺࣥ㸪࢚ࢱࣀ࣮ࣝ㸪⣧Ỉ࡟࡚10ศ㛫㉸㡢ἼὙίࢆ2ᅇࡎࡘ⾜࠸ヨᩱ࡜ࡋࡓ㸬ヨᩱ⾲㠃࡟0.2㸪0.5㸪1mMࡢ㖟࢖࢜ࣥ⁐ᾮࢆ⁲ୗࡋ㸪஝⇱ࡉࡏࡓᚋ࢔ࢽ࣮ࣝฎ⌮ࢆ⾜ࡗࡓ㸬࡞࠾㸪ࢥࣥࢺ࣮ࣟࣝヨᩱࡣ㸪㖟࢖࢜ࣥ⁐ᾮࢆࢥ࣮ࢸ࢕ࣥ
ࢢࡋ࡚࠸࡞࠸ࡶࡢ࡜ࡋࡓ㸬⾲㠃ᚤ⣽ᵓ㐀ࡢほᐹࡢࡓࡵ࡟㸪㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ࢆ⏝࠸࡚ほᐹࢆ⾜ࡗࡓ㸬ࡲࡓࢥ࣮ࢸ࢕ࣥࢢࡋࡓ㖟ࡢ⤖ᬗᵓ㐀ゎᯒࡢࡓࡵ
࡟X⥺ᅇᯒ࡟ࡼࡿゎᯒࢆ⾜ࡗࡓ㸬ᢠ⳦άᛶࡢホ౯࡟ࡣ㯤Ⰽࣈࢻ࢘⌫⳦ࢆ⏝࠸࡚ᢠ⳦ᛶヨ㦂㸦JIS Z 2801㸧ࢆ⾜ࡗࡓ㸬๓ᇵ㣴ࢆ⾜࠸㸪4107CFU/ml࡟ㄪᩚࡋࡓ⳦ᾮࢆ⏝࠸࡚㸪స〇ࡋࡓヨᩱୖ࡟᧛✀ࡋ37Υ24᫬㛫ᇵ㣴ࡋࡓ㸬ᇵ㣴ᚋࠊヨᩱୖࡢ⳦ᾮࢆᕼ㔘ࡋࠊᐮኳᇵᆅ࡟᧛✀ࡋ㸪37Υ
24᫬㛫ᇵ㣴ᚋ㸪ᙧᡂࡉࢀࡓࢥࣟࢽ࣮ࡢᩘࢆィ ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ㖟ࢆࢥ࣮ࢸ࢕ࣥࢢࡋࡓヨᩱࡢSEMീࢆᅗ࡟♧ࡍ㸬ࢥ࣮ࢸ࢕ࣥࢢࡋࡓ㖟⢏ᏊࡣYSZࡢヨᩱ⾲㠃࡟ศᩓࡋ࡚࠸ࡓ㸬ࡲࡓXRDᅇᯒࡢ⤖ᯝ㸪௜╔ࡋ࡚࠸ࡿ⢏Ꮚࡣ㖟࡛࠶ࡿࡇ࡜ࡀࢃ࠿ࡗࡓ㸬ࢥ࣮ࢸ࢕ࣥࢢࡋࡓヨᩱୖ࡟࡚ᇵ㣴ࡋࡓ⳦ࡢࢥ
ࣟࢽ࣮ᩘࢆィ ࡋᢠ⳦άᛶ್ࢆồࡵࡓ࡜ࡇࢁ㸪㖟ࡢ⃰ᗘࡢୖ᪼࡟కࡗ࡚ࢥࣟࢽ࣮ᩘࡢῶᑡ㸪ᢠ⳦άᛶ್ࡢୖ᪼ࡀㄆࡵࡽࢀࡓ㸬௨ୖࡼࡾ㸪㖟ࡢࢥ࣮ࢸ࢕ࣥࢢࢆ᪋ࡋࡓYSZࡣᢠ⳦άᛶࢆ᭷ࡋ࡚࠾ࡾ㸪㖟࢖࢜ࣥࡢ≧ែ࡛ຠᯝࡀⓎ᥹ࡉࢀ࡚࠸ࡿࡇ࡜ࡀ♧ࡉࢀࡓ㸬

1mM ࡢ㖟ࢥ࣮ࢸ࢕ࣥࢢࢆ᪋ࡋࡓ YSZ ⾲㠃ϫ㸬ᩥ⊩㸬1㸧 Kaijin Xu, Yuanyuan Liu, Shaomin Liu,Aoyang Liu,
Pengyun Liu,Lihong Liu,Lanjuan Li. Microorganism
adhesion inhibited by silver doped Yttria-stabilized
zirconia ceramics Ceram.Int 39(2011)2109-2115− 155 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 25␗࡞ࡿẼᏍ⋡ࢆ᭷ࡍࡿⅣ㓟ྵ᭷࢔ࣃࢱ࢖ࢺࡢ㦵ᙧᡂ⬟ホ౯‫ۑ‬㔝ᓮᾈభ㸪⸨⏣࿴ஂ*㸪ᒣୗோ኱**㸪୕ᾆᏹஅ*㸪Ọ஭ளᕼᏊᮾி་⛉ṑ⛉኱Ꮫ⏕యᮦᩱᕤᏛ◊✲ᡤ⏕యᮦᩱᶵ⬟་Ꮫศ㔝㸪**↓ᶵ⏕యᮦᩱᏛศ㔝㸪*ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔 ་ṑᏛ⥲ྜ◊✲⛉ ᦤ㣗ᶵ⬟ಖᏑᏛศ㔝
Effect of porous carbonated apatite with different posrosity on bone formation

Nozaki K, Fujita K*, Yamashita K**, Miura H*, Nagai A.
Department of Material Biofunctions, **Department of Inorganic Biomaterials, Institute of Biomaterials andBioengineering, Tokyo Medical and Dental University, *Department of Fixed Prosthodontics, Graduate Schoolof Medical and Dental Sciences, Tokyo Medical and Dental University.

Ϩ㸬 ┠ⓗ ㏆ᖺ㸪ṑ⛉࢖ࣥࣉࣛࣥࢺ἞⒪ࡸṑ࿘እ⛉἞⒪࡟
࠾࠸࡚㸪㦵⿵ሸᮦࡢ౑⏝ࡀᣑ኱ࡋ࡚࠸ࡿ㸬㦵⿵ሸᮦ࡟ࡣ㸪⮬ᐙ㦵ࡸ௚ᐙ㦵㸪ேᕤ㦵ࡀ࠶ࡾ㸪⑕౛࡟ᛂࡌ࡚ࡑࢀࡒࢀࢆ㑅ᢥࡍࡿ㸬୰࡛ࡶேᕤ㦵ࡣ⏕యᏳ඲ᛶ࡟ඃࢀ࡚࠸ࡿࡇ࡜ࡸ㸪ከ㔞࡟ኻࢃࢀࡓḞᦆ㒊ศࢆ⿵ሸࡍࡿࡇ࡜ࡀ࡛ࡁࡿࡇ࡜࠿ࡽ㸪ᖜᗈࡃ⮫ᗋᛂ⏝ࡉࢀ࡚࠸ࡿ㸬ᡃࠎࡣ㸪㦵ࡢ↓ᶵ୺ᡂศ࡛࠶ࡿࣁ࢖ࢻࣟ࢟ࢩ࢔
ࣃࢱ࢖ࢺ㸦Ca10(PO4)6(OH)2 㸪HAp㸧ࡢࣜࣥ㓟ᇶࡢ୍㒊ࢆⅣ㓟ᇶ࡟⨨ࡁ᥮࠼ࡓⅣ㓟⨨᥮ᆺHAp㸦CA㸧ࢆ⏝࠸ࡓ᪂つேᕤ㦵ࢆ㛤Ⓨࡋ㸪ࡑࡢ⏕యෆ࡛ࡢᣲ
ືࢆሗ࿌ࡋ࡚ࡁࡓ 1) 㸬CAࡣ⏕యෆ࡟࠾࠸࡚྾཰࣭
⁐ゎࡍࡿࡇ࡜࠿ࡽ㸪ḟୡ௦ࡢ㦵ࣜࣔࢹࣜࣥࢢྍ⬟࡞㦵⿵ሸᮦ࡜ࡋ࡚ᮇᚅࡉࢀࡿࡀ㸪ከᏍయ࡜ࡋ࡚⏝࠸ࡓሙྜ࡟㸪ࡑࡢẼᏍ⋡ࡀ㦵ᙧᡂࡸ㸪࢔ࣃࢱ࢖ࢺ
ࡢ྾཰࣭⁐ゎ࡟ཬࡰࡍᙳ㡪ࡣヲ⣽࡟᳨ウࡉࢀ࡚࠸࡞࠸㸬ࡑࡇ࡛㸪ᮏᐇ㦂࡛ࡣ㸪HAp࠾ࡼࡧCAࢆ⏝࠸࡚2✀㢮ࡢẼᏍ⋡ࢆ᭷ࡍࡿከᏍయࢆస〇ࡋ㸪ࡑࢀࡒࢀࡢ㦵ᙧᡂ⬟࡜⏕యෆࡢᣲືࢆẚ㍑ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡍࡿ㸬ࡲࡓ㸪ᇙධ㒊఩ࢆᾏ⥥㦵㸪⓶㉁㦵㸪㦵㧊࡟ศ㢮ࡋ㸪ᇙධ㒊఩࡟ࡼࡿேᕤ㦵ࡢ㦵ᙧᡂ⬟࠾ࡼࡧᣲືࢆẚ㍑᳨ウࡍࡿ㸬ϩ㸬 ᪉ἲ HApࡣ‵ᘧྜᡂࡋࡓHAp⢊ᮎࢆ⏝࠸ࡓ㸬CAࡣ㸪◪㓟࢝ࣝࢩ࣒࢘ᅄỈ࿴≀㸪Ⅳ㓟ࢼࢺ࣒ࣜ࢘㸪ࣜࣥ㓟Ỉ⣲ࢼࢺ࣒ࣜ࢘ࢆฟⓎཎᩱ࡜ࡋ࡚‵ᘧἲ࡟ࡼࡾ
ྜᡂࡋ㸪CA⢊ᮎࢆᚓࡓ㸬ࡑࢀࡒࢀࡢ⢊ᮎࢆ⏝࠸࡚┤ᚄ3ੈ㸪㧗ࡉ5ੈ࡟࡞ࡿࡼ࠺࡟ከᏍయࢆస〇ࡋࡓ㸬 ᐇ㦂ື≀࡜ࡋ࡚㸪10㐌㱋㞝᪥ᮏⓑⰍᐙඡࢆ⏝࠸ࡓ㸬 㸦ᮾி་⛉ṑ⛉኱Ꮫື≀ᐇ㦂ጤဨ఍ᢎㄆ
␒ྕ㸸0110093A㸧 ඲㌟㯞㓉ᚋ㸪ᕥྑ኱⭣㦵ෆഃୖ㢛࠾ࡼࡧᕥྑ⬯㦵ෆഃ㠃࡟࢖ࣥࣉࣛࣥࢺ❐ᙧᡂ⏝ࡢ࣮࣐࣮ࣜࢆ⏝࠸࡚┤ᚄ3ੈ㸪῝ࡉ5ੈࡢ㦵Ḟᦆࢆᙧᡂࡋ㸪స〇ࡋࡓࡑࢀࡒࢀࡢከᏍయࢆᇙධࡋࡓ㸬ᇙධᚋ㸪4㸪12㐌㛫ᚋ࡟㸪ከᏍయࢆྵࡴ኱⭣㦵࠾ࡼࡧ⬯㦵ࢆ᦬ฟࡋࣃ࣒ࣛ࣍ࣝ࢔ࣝࢹࣄࢻ࡟࡚ᅛᐃᚋ㸪㏻ἲ࡟ᚑ࠸ᶞ⬡ᶆᮏࢆస〇ࡋࡓ㸬 స 〇 ࡋ ࡓ ᶞ ⬡ ᶆ ᮏ ࢆ ࣐ ࢖ ࢡ ࣟ CT 㸦 Inspexio
SMX100ct 㸪 ᓥ ὠ 〇 స ᡤ 㸧 ࠾ ࡼ ࡧ ゎ ᯒ ࢯ ࣇ ࢺ
㸦TRI3D/Bon㸪ࣛࢺࢵࢡࢩࢫࢸ࣒࢚ࣥࢪࢽ࢔ࣜࣥ
ࢢ㸧ࢆ⏝࠸࡚㸪ከᏍయෆ࡟ᙧᡂࡉࢀࡓ㦵ᐦᗘ࠾ࡼࡧከᏍయᐦᗘࢆィ ࡋࡓ㸬ࡲࡓᶞ⬡ᶆᮏࢆཌࡉ⣙30μm࡟ⷧษࡋ㸪ࢺࣝ࢖ࢪࣥࣈ࣮ࣝ࡟࡚ᰁⰍࡋ㸪⤌⧊Ꮫⓗホ౯ࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ స〇ࡋࡓCAከᏍయࡢෆ㒊ᵓ㐀ࢆ࣐࢖ࢡࣟCT࡟࡚
ほᐹࡋࡓ㸦ᅗ㸧㸬ከᏍయෆ㒊ࡣ㐃㏻ࡍࡿ࣐ࢡࣟẼᏍ࠾ࡼࡧ࣑ࢡࣟẼᏍࢆ᭷ࡋ㸪HApࡢẼᏍ⋡ࡣࡑࢀࡒࢀ㸪63.1%㸪59%࡛࠶ࡗࡓ㸬CAࡢẼᏍ⋡ࡣ62.4%㸪
52.2%࡛࠶ࡗࡓ㸬 ᐇ㦂ື≀࡟ᇙධᚋࡢHAp࠾ࡼࡧCAከᏍయෆ㒊࡟ࡣ㸪࠸ࡎࢀࡢᇙධ㒊఩࡟࠾࠸࡚᪂⏕㦵ࡢᙧᡂࡀㄆ
ࡵࡽࢀࡓ㸬ẼᏍ⋡ࡢኚ໬࡟ࡼࡿCAࡢ྾཰࣭⁐ゎࡢᣲື࡟㐪࠸ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬௨ୖࡼࡾ㸪ᮏᐇ㦂᮲௳࡛ࡣ㸪ẼᏍ⋡ࡢ㐪࠸ࡣCAࡢ⏕యෆࡢᣲື࡟
ᙳ㡪ࢆཬࡰࡉ࡞࠸ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ᇙධ๓ࡢ CA ከᏍయࡢ࣐࢖ࢡࣟ CT ീϫ㸬 ᩥ⊩1) Nagai A., Yamashita K. et al. Electric polarizationand mechanism of B-type carbonated apatite
ceramics. JBMR part A, 99(1); 116-124, 2011.

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一般口演発表1 ─ 3 ─ 26⚄⤒ᆺȘࢽࢥࢳࣥᛶ࢔ࢭࢳࣝࢥࣜࣥཷᐜయࡣ◚㦵⣽⬊ࡢศ໬ㄪ⠇࡟㛵୚ࡍࡿ‫┒ۑ‬ᯘ᫛ோ*㸪ᒣᮏ἞Ẏ*㸪㙊㔝ඃᘺ*,**㸪ⴛᓥᾈ㍤*㸪Ụⲡ ᏹ*,**㸪▮㇂༤ᩥ**኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ 㢡ཱྀ⭍ᶵ⬟෌ᘓᏛㅮᗙ ࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫศ㔝**ᮾ໭኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ ศᏊ࣭෌⏕ṑ⛉⿵⥛Ꮫศ㔝
Involvement of neuronal nicotinic acetylcholine receptor alpha7 in osteoclast differentiation
Moribayashi A*, Yamamoto H*, Kamano Y*,**, Kayashima H*, Egusa H*,**, Yatani H**Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry, **Department of
Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of DentistryϨ㸬 ┠ⓗ㧗ᗘ࡞㢡ሐ྾཰ࡣ㸪⩏ṑࡢ⥔ᣢ㸪Ᏻᐃࢆᅔ㞴ࡍࡿࡤ࠿ࡾ࡛࡞ࡃ㸪࢖ࣥࣉࣛࣥࢺ἞⒪ࡢྍྰࡸࡑࡢ
ᑂ⨾ᛶ࡟ࡶᙳ㡪ࢆཬࡰࡍࡓࡵ㸪⿵⥛ṑ⛉⮫ᗋ࡟࠾࠸࡚ྂࡃࡼࡾ᪥ᖖⓗ࡟┤㠃ࡍࡿ㞴㢟࡛࠶ࡿ㸬㢡㦵྾཰ࡣ◚㦵⣽⬊࡟≉␗ⓗ࡞స⏝࡛࠶ࡾ㸪⌧ᅾࡢᢠ㦵྾཰἞⒪ࡣࡇࡢ◚㦵⣽⬊ࢆᶆⓗ࡜ࡋ࡚࠸ࡿ㸬◚㦵⣽⬊ศ໬࡟ࡣ NFATc1 ࡢάᛶ໬ࡀᚲ㡲࡛࠶ࡾ㸪ࡇࢀࢆྖࡿࢩࢢࢼࣝఏ㐩ᶵᵓࡢゎ᫂࡟ὀ┠ࡀ㞟ࡲࡗ࡚࠸ࡿ㸬ᡃࠎࡣࡇࢀࡲ࡛࡟⣽⬊ㄪ⠇ᅉᏊ࡜ࡋ࡚㸪ศᏊ㔞ࡀᑠࡉࡃ㸪Ᏻ౯࡛㸪໬Ꮫྜᡂ࣭ಟ㣭ࡀᐜ᫆࡞ᑠศᏊ໬ྜ≀࡟╔┠ࡋ࡚ࡁࡓ 1)㸬
ᮏ◊✲ࡢ┠ⓗࡣ㸪◚㦵⣽⬊ศ໬࡟ᙳ㡪ࢆཬࡰࡍᑠศᏊ໬ྜ≀ࢆ᥈⣴ࡋ㸪ࡑࡢᶆⓗศᏊࢆ᫂ࡽ࠿࡟
ࡍࡿࡇ࡜࡛᪂ࡓ࡞◚㦵⣽⬊ࡢศ໬ㄪ⠇ᶵᵓࢆぢฟࡍࡇ࡜࡛࠶ࡿ㸬ϩ㸬 ᪉ἲ◚ 㦵 ๓ 㥑 ⣽ ⬊ 㸦 RAW264.7 㸧 ࠿ ࡽ ᶞ ❧ ࡋ ࡓ
NFAT/ࣝࢩࣇ࢙࣮ࣛࢮ࣏࣮ࣞࢱ࣮㑇ఏᏊᏳᐃⓎ⌧ᰴࢆ ⏝ ࠸ ࡚㸪1,280✀㢮ࡢᑠศᏊ໬ྜ≀ࢆྵࡴ
LOPACK1280 ࣛ࢖ࣈ࣮ࣛࣜ㸦SIGMA♫㸧ࡢࢫࢡ࣮ࣜࢽࣥࢢࢆ⾜ࡗࡓ㸬ࡲࡓ㸪ೃ⿵໬ྜ≀࠾ࡼࡧ࢔ࢭ
ࢳࣝࢥ࢚ࣜࣥࢫࢸ࣮ࣛࢮ➼ࡀ◚㦵⣽⬊ศ໬࡟ཬࡰ
ࡍᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ㸪ࡇࢀࡽࡢᅉᏊࢆRANKL࡜࡜ࡶ࡟RAW264.7⣽⬊࠶ࡿ࠸ࡣ࣐࢘ࢫ㦵㧊⣽⬊࡟ῧຍࡋ㸪5㹼6᪥ᚋ࡟TRAPᰁⰍࢆ⾜࠸㸪㝧ᛶࡢከ᰾⣽⬊ᩘࢆィ ࡋࡓ㸬ࡉࡽ࡟㸪ೃ⿵໬ྜ≀ࢆ㢌⵹㦵Ḟᦆࣛࢵࢺᐇ㦂ࣔࢹࣝ࡟ᢞ୚ࡋ㸪⾡ᚋ21᪥ᚋࡢ㦵⤌⧊෌⏕ࢆ㸪HEᰁⰍ࡟ࡼࡿ⤌⧊Ꮫⓗほᐹ࠾ࡼࡧ࣐࢖ࢡࣟCT᧜ᙳࢆ⏝࠸ࡓ⏬ീゎᯒ࡟ࡼࡾホ౯ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹࣛ࢖ࣈ࣮ࣛࣜࢫࢡ࣮ࣜࢽࣥࢢࡢ⤖ᯝ㸪NFAT άᛶࢆಁ㐍ࡍࡿ໬ྜ≀࡜ࡋ࡚㸪ࢥ࢚ࣜࣥࢫࢸ࣮ࣛࢮ
㜼ᐖ⸆࡛࠶ࡿ Phenserine ࠾ࡼࡧ Donepezil ࢆぢฟࡋࡓ㸬ࡑࡇ࡛㸪◚㦵⣽⬊ศ໬ㄪ⠇࡟࠾ࡅࡿ࢔ࢭࢳࣝ
ࢥࣜࣥ⣔ࡢ㛵୚ࢆ௬ㄝ࡜ࡋ㸪࢔ࢭࢳࣝࢥ࢚ࣜࣥࢫ

ࢸ࣮ࣛࢮ࠾ࡼࡧ⚄⤒ᆺࢽࢥࢳࣥᛶ࢔ࢭࢳࣝࢥࣜࣥ
ཷᐜయ㸦nAChR㸧㜼ᐖ⸆㸦Mecamylamine㸧ࢆ⏝࠸ࡓศ໬ㄏᑟᐇ㦂ࢆ⾜ࡗࡓ⤖ᯝ㸪ࡇࢀࡽࡢᅉᏊࡣ◚㦵⣽⬊ᙧᡂࢆ᭷ព࡟ᢚไࡋࡓ㸦㸺0.01㸧㸬୍᪉㸪࣒ࢫ࢝ࣜࣥᛶ࢔ࢭࢳࣝࢥࣜࣥཷᐜయ㜼ᐖ⸆㸦 Scopolamine 㸧 ࠾ ࡼ ࡧ ➽ ⫗ ᆺ nAChR 㜼 ᐖ ⸆㸦Tubocurarine㸧ࡣศ໬ᢚไస⏝ࢆ♧ࡉ࡞࠿ࡗࡓࡇ
࡜࠿ࡽ㸪◚㦵⣽⬊ศ໬࡟࠾ࡅࡿ⚄⤒ᆺ nAChR ࡢ㛵୚ࡀ♧၀ࡉࢀࡓ㸬ࡲࡓ㸪࢙࢘ࢫࢱࣥࣈࣟࢵࢺゎᯒࡢ⤖ᯝ㸪◚㦵๓㥑⣽⬊ࡣ nAChR ࡢ 7 ࢧࣈࣘࢽࢵ
ࢺࢆⓎ⌧ࡋ࡚࠾ࡾ㸪7nAChR ࡢ≉␗ⓗ㜼ᐖ⸆࡛࠶ࡿ Methyllycaconitine㸦MLA㸧࠾ࡼࡧ -bungarotoxinࡣ㸪10-100 nM ࡢ⃰ᗘ࡛◚㦵⣽⬊ࡢศ໬ࢆᙉຊ࡟ᢚ
ไࡋࡓ㸦㸺0.01㸧㸬㢌⵹㦵Ḟᦆ㒊఩࡬ࡢ MLA ᢞ୚ࡢ⤖ᯝ㸪㦵య✚࠾ࡼࡧ㦵ሷ㔞㸦㸺0.01㸧ࡣ᭷ព࡟ቑຍࡋࡓ㸦ᅗ㸧㸬௨ୖࡢ⤖ᯝ࠿ࡽ◚㦵⣽⬊ࡢศ໬ㄪ⠇࡟ࡣ࢔ࢭࢳ
ࣝࢥࣜࣥࡀ㛵୚ࡋ࡚࠾ࡾ㸪◚㦵๓㥑⣽⬊࡟Ꮡᅾࡍࡿ 7nAChR ࢆ௓ࡋࡓ᝟ሗఏ㐩ࡀࡑࡢศ໬࡟㛵୚ࡋ࡚࠸ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ᅗ㸬 Methyllycaconitine㸦5,000 ng/site㸧ࡢ㦵෌⏕ಁ㐍స⏝఍ဨእඹྠ◊✲⪅㸸బ఑୓㥽⏨㸦᪂₲኱Ꮫ኱Ꮫ㝔་ṑ⸆⥲ྜ◊✲⛉ ṑ⛉⸆⌮Ꮫศ㔝 ᩍᤵ㸧㸪Ỉ⏣ளᕼᏊ㸪ୖᓮၿつ㸦኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉
ྡ㄃ᩍᤵ㸧
ϫ㸬 ᩥ⊩
1) Egusa H, Saeki M, Fukuyasu S et al. A smallmolecule approach to bone regenerative
medicine in dentistry. J Oral Biosci 2010;52:107-18.

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一般口演発表1 ─ 3 ─ 27

Ni࢖࢜ࣥ࡟ࡼࡿཱྀ⭍⒴㌿⛣ᢚไຠᯝࡢ᳨ウ‫ۑ‬ሷ㔝┠ᑦ㸪኱ᯘ⨾✑㸪ᱵᕝ⩏ᛅ㸪᭶ᮧ┤ᶞ㸪᳃⏣ᰤ୍㸪Ᏹ⨾㝯⏕㸪▼ୖ཭ᙪ᪥ᮏ኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨ϩㅮᗙAssessment of anti-metastatic effect of Nickel ion on oral squamous cell carcinoma
Shionome T㸪Obayashi M㸪Umekawa Y㸪Tsukimura N㸪Morita E㸪Umi T㸪Ishigami T
Department of Partial Denture Prosthodontics, Nihon University school of DentistryϨ㸬 ┠ⓗࢽࢵࢣࣝ㸦Ni㸧ࡣṑ⛉⿵⥛἞⒪࡛౑⏝ࡉࢀࡿࢽࢵ
ࢣࣝࢡ࣒ࣟྜ㔠ࡸࢥࣂࣝࢺࢡ࣒ࣟྜ㔠࡟ྵ᭷ࡉࢀ
࡚࠾ࡾ㸪㔠ᒓ࢔ࣞࣝࢠ࣮ࡢཎᅉ࡜࡞ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ㸬ࡇࢀࡲ࡛₇⪅ࡽࡣ㸪Niࡀཱྀ⭍ᡥᖹୖ⓶⒴⣽⬊࡟୚࠼ࡿᙳ㡪ࢆ᳨ウࡋࡓ⤖ᯝ㸪Ni࢖࢜ࣥࡀ㸪㌿෗ᅉᏊ࡛࠶ࡿNF-B p50 subunit࡜┤᥋⤖ྜࡋ㸪
p50 subunitࡢ᰾ෆ⛣⾜ࢆ㜼ᐖࡍࡿࡇ࡜࡟ࡼࡾNF-NBάᛶࢆᢚไࡍࡿࡇ࡜ࢆぢฟࡋࡓ1㸪2)㸬⒴ࡢቑṪ࣭㌿⛣ࡣNF-NBάᛶ࡜┦㛵ࢆ♧ࡍࡇ࡜࠿ࡽNF-Bάᛶ㜼ᐖຠᯝࡣ㸪Ni࢖࢜ࣥࢆ⒴἞⒪࡟ᛂ⏝ࡋ࠺ࡿྍ⬟ᛶࢆ♧၀ࡍࡿࡶࡢ࡛࠶ࡗࡓ㸬ࡑࡇ࡛ᮏ◊✲ࡣ㸪Ni࢖࢜ࣥ࡟ࡼࡿ⒴㌿⛣ᢚไຠᯝࡢྍ⬟ᛶࢆ㏣ồࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬

࡭࡚ࡢMMP㑇ఏᏊࡢⓎ⌧ࡀ㧗ᗘ࡟ᢚไࡉࢀ࡚࠸ࡓ㸬
ࡑࡋ࡚MMP9࡟㛵ࡋ࡚ࡣ㸪ᅗ࡟♧ࡋࡓ㏻ࡾNiᏑᅾୗ࡛㌿෗ࣞ࣋ࣝࡢⓎ⌧ᢚไࡀ☜ㄆࡉࢀࡓ㸬
luciferase assayࡢ⤖ᯝ㸪NF-NBࡢ2ࡘbinding siteࡢෆ㸪ୗὶࡀ≉࡟㔜せ࡛࠶ࡿࡇ࡜ ࡀศ࠿ࡗࡓ㸬ࡲࡓ
࡟࠾ࡅࡿ⭘⒆ᙧᡂᐇ㦂࡟ࡼࡾච␿⤌⧊Ꮫⓗ࡟
MMPⓎ⌧ࡢኚ໬࡟ࡘ࠸᳨࡚ウࡋࡓ࡜ࡇࢁ㸪ࡍ࡭࡚
ࡢMMPⓎ⌧ࡣNiᏑᅾୗ࡛ᢚไࡉࢀ࡚࠸ࡿࡇ࡜ࡀ᫂
ࡽ࠿࡜࡞ࡗࡓ㸬ࡉࡽ࡟ᡤᒓࣜࣥࣃ⠇࠿ࡽᢳฟࡋࡓ
genomic DNAࢆ⏝࠸ࡓnested-PCRࡢ⤖ᯝ㸪Niࡀ⒴㌿⛣ࢆᴟࡵ࡚ຠ⋡ⓗ࡟ᢚไࡍࡿࡇ࡜ࡀゎࡗࡓ㸬௨ୖࡢ⤖ᯝࡼࡾ㸪Ni࢖࢜ࣥࡢNF-NBάᛶᢚไࡣ
MMPⓎ⌧ࡢᢚไࢆ௓ࡋ࡚⒴㌿⛣ࢆᢚไࡍࡿࡇ࡜ࡀ
♧၀ࡉࢀࡓ㸬ϩ㸬 ᪉ἲཱྀ ⭍ ⒴ ⣽ ⬊ ᰴ 㸦 HSC-3 㸪 HSC3-M3 㸧 ࡣ 㸪 10%
FCS-RPMI1640ࡲࡓࡣ10%FCS-MEMᇵᆅ࡟ࡼࡾ㸪37Υ㸪5% CO2 ࢖࣮ࣥ࢟ࣗ࣋ࢱ࣮ෆ࡛ᇵ㣴ࡋࡓ㸬
Matrix metalloproteinase㸦MMP㸧ࡢⓎ⌧࡟㛵ࡋ࡚ࡣ㸪
HSC-3⣽⬊ࢆ2x105/24-well plate࡟᧛✀ࡋ㸪NiᏑᅾୗ㸪㠀Ꮡᅾୗ่࡛⃭ᚋ㸪RNAࢆᢳฟࡋcDNAࢆస〇ࡋࡓ㸬ࡑࡢᚋ㸪real-time PCRࢆ⾜࠸㑇ఏᏊ᳨࡛ࣞ࣋ࣝウࡋࡓ㸬⭘⒆ᙧᡂᐇ㦂ࡣ㸪BALB/cAJcl-nu/nu࣐࢘ࢫ࡟HSC3-M3⣽⬊ࢆ5x105/30ul࡜࡞ࡿࡼ࠺ㄪᩚᚋ㸪⯉ᕥഃ㎶⦕࡟⛣᳜ࡋࡓ㸬⭘⒆ᙧᡂࢆ⫗║ⓗ࡟☜ㄆᚋ㸪Ni㸦1mM㸧ࢆῧຍࡋࡓỈࢆ14᪥㛫⮬⏤㣧Ỉࡉࡏ㸪ཎⓎᕢ࠿ࡽ⤌⧊ࢆ᦬ฟࡋච␿ᰁⰍ࡟ࡼࡾẚ㍑
᳨ウࡋࡓ㸬ࡉࡽ࡟㸪⛣᳜3㐌ᚋࡢཱྀ⭍⒴㌿⛣ࣔࢹ࣐ࣝ࢘ࢫࡢ⯉㸪ࣜࣥࣃ⠇㸪⫵࠿ࡽgenomic DNAࢆᢳฟࡋ㸪ࣄࢺ-globin㑇ఏᏊࢆnested-PCR࡟ࡼࡾ᳨ฟ
ࡍࡿࡇ࡜࡟ࡼࡾNiࡢ⒴㌿⛣ᢚไຠᯝ࡟ࡘ࠸᳨࡚ウࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
MMP1㸪2㸪9㸪14ࡢⓎ⌧࡟ࡘ࠸᳨࡚⣴ࡋࡓ⤖ᯝ㸪
HSC3ࡣⓎ⌧ࡢ⛬ᗘࡣ␗࡞ࡿࡶࡢࡢᜏᖖⓗ࡟ࡇࢀࡽࡍ࡭࡚ࡢ㑇ఏᏊࢆⓎ⌧ࡋ࡚࠾ࡾ㸪NiᏑᅾୗ࡛ࡣࡍ

ᅗ MMP9 ࡟ᑐࡍࡿ NF-N%ࡢ㌿෗άᛶ㔞ϫ㸬 ᩥ⊩1) Takashi S, Shigeki E, Daisuke O et al. Nickel Ion
Inhibits Nuclears Factor-Kappa B Activity in
Human Squamous Cell Carcinoma. PLOS ONE
2013; 8(7): e68257, doi10. 137.
2) 㐲⸨ⱱᶞ, ᑿ᭤኱㍜, ὸ㔝ṇᓅ, ࡯࠿. Ni࢖࢜ࣥ࡟ࡼࡿཱྀ⭍ᡥᖹୖ⓶⒴ࡢNF-KBࢆ௓ࡋࡓ
IL-8Ⓨ⌧ࡢᢚไ. ᪥኱ṑᏛ2012; 86(2): 107-111㸬

− 158 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 28ࣛࢪ࢔ࣝࣇ࣮ࣟᆺࣂ࢖࢜ࣜ࢔ࢡࢱ࣮ࢆ⏝࠸ࡓࣛࢵࢺ㦵㧊⣽⬊ࡢ୕ḟඖᇵ㣴‫⏣⚄ۑ‬㞝ᖹ Ꮿ㛫⿱௓ బ⸨ ஽ ᪂㇂ᫀ᫂ ᅄࢶ㇂ㆤ Ⲩ㔝ኴ୍ ∦ᒣឡᏊ ᐑ஭཭⌮*ᮾிṑ⛉኱ᏛṑᏛ㒊ࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫㅮᗙ*ᮾிṑ⛉኱Ꮫཱྀ⭍⛉Ꮫ◊✲ࢭࣥࢱ࣮**Three-Dimensional Culture of Rat Bone Marrow Cells Using Radial Flow Bioreactor.
Kanda Y, Takuma T*, Sato T*, Shinya A*, Yotsuya M*, Arano T, Katayama A,Miyai Y
Department of Crown and Bridge Prothodontics ,Tokyo Dental College*
Oral Health Science Center , Tokyo Dental College**Ϩ㸬 ┠ⓗ 㦵㧊ࡼࡾᢳฟࡋࡓ⣽⬊࡟㦵ศ໬ᅉᏊࢆῧຍࡋᇵ
㣴ࡍࡿ࡜㦵⣽⬊࡬࡜ศ໬ࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸
ࡿ. ࡲࡓ, ࡛స〇ࡉࢀࡓ⣽⬊-ࢫ࢟ࣕࣇ࢛ࣝࢻ
」ྜయࡣ㦵෌⏕࡟࠾࠸࡚᭷ຠ࡞ᡭẁ࡛࠶ࡿࡇ࡜ࡀ
ሗ࿌ࡉࢀ࡚࠸ࡿ. ᡃࠎࡣ, ࣛࢪ࢔ࣝࣇ࣮ࣟᆺࣂ࢖࢜
ࣜ࢔ࢡࢱ࣮ (RFB) (ᅗ)ࢆ⏝࠸ࡓ࣐࢘ࢫ㦵ⱆ⣽⬊ᵝ⣽⬊ࡢᇵ㣴࠾ࡼࡧࣄࢺ㦵㧊⏤᮶㛫ⴥ⣔ᖿ⣽⬊ࡢᇵ㣴࡛ࢫ࢟ࣕࣇ࢛ࣝࢻୖ࡟ᆒ୍࡟ቑṪࡉࡏࡿࡇ࡜ࢆ
ሗ࿌ࡋ࡚࠸ࡿ.1)2) ࡋ࠿ࡋ, RFBࢆ⏝࠸࡚Primary Cellࡢ⣽⬊ࢆቑṪࡉࡏ㦵෌⏕ࢆホ౯ࡋࡓሗ࿌ࡣࡲࡔ࡞
࠸. ࡑࡇ࡛ᮏ◊✲ࡢ┠ⓗࡣ, RFBࢆ⏝࠸࡚Primary
Cellࡢࣛࢵࢺ㦵㧊⣽⬊ࢆᇵ㣴ࡋ࡚ࡑࡢືែࢆ᳨ウࡍࡿࡇ࡜࡟ࡼࡾ, ᮏἲࡀ ࡛ࡢᛂ⏝࡟᭷ຠ࡛࠶ࡿ
࠿ࢆ⪃ᐹࡋࡓ.
ϩ㸬 ᪉ἲ 㞝ᛶ, SD⣔, 6㐌㱋ࡢࣛࢵࢺࢆᒕẅࡋ㦵㧊⣽⬊ࢆ኱⭣㦵, ୖ⭎㦵, ⬯㦵ࡼࡾ᥇ྲྀࡋࡓ. ึ௦ᇵ㣴ࡢࡳ㦵ศ໬ᅉᏊ㸦ࢹ࢟ࢧ࣓ࢱࢰࣥ10-8M, ș-ࢢࣜࢭࣟࣜ
ࣥ㓟10mM, 50μg/ml࢔ࢫࢥࣝࣅࣥ㓟㸧ࢆῧຍࡋࡓDMEM࡟࡚ᇵ㣴ࡋ, 2⥅௦┠ࡲ࡛㦵ศ໬ᅉᏊࢆῧຍࡋ
࡚࠸࡞࠸D-MEM࡟࡚ᇵ㣴ࡋࡓ. ࡑࡢᚋࢱ࢖ࣉ1ࢥ࣮ࣛࢤࣥࢩ࣮ࢺ㸦ẼᏍᚄ70㹼110μm, ẼᏍ⋡80㹼
95㸣, ┤ᚄ18mm, ཌࡉ3mm㸧࡟5×105ಶࡢ⣽⬊ࢆ᧛✀ࡋ, ࢩ࣮ࢺࢆ6ᯛ㔜ࡡ࡛RFB࡟ྲྀࡾ㎸ࡳ℺ὶᇵ㣴ࢆ⾜ࡗࡓ. ᇵ㣴᮲௳ࡣ37Υ, pH7.4, DO್6.86ppm,
ᇵ㣴ᾮ஺᥮㔞100ml/day, ᇵ㣴ᾮ℺ὶ㏿ᗘ3ml/min࡟タᐃࡋ,ᇵᆅ஺᥮ࡣᇵ㣴㛤ጞᚋ3᪥┠࠿ࡽẖ᪥࡜ࡋ
ࡓ. 1㐌㛫ᚋ࡟ࢫ࢟ࣕࣇ࢛ࣝࢻࢆᅇ཰ࡋHEᰁⰍ࡟ࡼࡿᙧែほᐹ࡜⣽⬊ᩘ, ALPάᛶࢆホ౯ࡋࡓ. ࢥࣥࢺ࣮ࣟࣝ࡜ࡋ࡚ᇵᆅ℺ὶࢆ⾜ࢃࡎ࡟ࣉ࣮ࣞࢺୖ࡛㟼⨨ᇵ㣴ࡋࡓࡶࡢࢆ⏝࠸ࡓ.

ࡃ⾜ࢃࢀࡓࡓࡵ࡜᥎ᐹࡉࢀࡓ, ࡋ࠿ࡋ, ALPάᛶ࡟ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ, ௨ୖࡼࡾ, RFB࡟ࡼࡾࢫ࢟
ࣕࣇ࢛ࣝࢻୖ࡟ࣛࢵࢺ㦵㧊⣽⬊ࢆ㧗ᐦᗘ࡟ቑṪࡉࡏࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾ, RFBࢆ⏝࠸ࡓ⣽⬊-ࢫ࢟ࣕࣇ࢛ࣝࢻ」ྜయࡣ ࡛ࡢᛂ⏝࡟᭷ຠ࡛࠶ࡿ
ྍ⬟ᛶࡀ♧၀ࡉࢀࡓ.

ᅗ ࣛࢪ࢔ࣝࣇ࣮ࣟᆺࣂ࢖࢜ࣜ࢔ࢡࢱ࣮ϫ㸬 ᩥ⊩1) Katayama A, Yoshinari M,   . Radial FlowBioreactor enables uniform proliferation ofhuman mesenchymal stem cells throughout athree-dimensional scaffold.
Tissue Engineering: part C 2013;19;109-16
2)
Arano T, Yoshinari M,    Osteoblastic
proliferation with uniform distribution in a large
scaffold using radial flow-bioreactor.
Tissue Engineering: part C 2010;16;1387-98

Ϫ㸬 ⤖ᯝ࡜⪃ᐹ RFBࢆ⏝࠸࡚ࣛࢵࢺ㦵㧊⣽⬊ࢆᇵ㣴ࡋࡓ⤖ᯝ, ࢥࣥࢺ࣮ࣟࣝ࡜ẚ㍑ࡋ࡚⣽⬊ᩘࡣ᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ. ࡲࡓ, H-EᰁⰍ࡟ࡼࡾࢫ࢟ࣕࣇ࢛ࣝࢻୖ࡛㧗ᐦᗘ࡟⣽⬊ࡀศᕸࡋ࡚࠸ࡿࡇ࡜ࡀほᐹࡉࢀࡓ. ࡇ
ࢀࡣ, ᰤ㣴※ࡢ౪⤥, ⪁ᗫ≀ࡢ᤼ฟࡀRFB࡛ຠ⋡ࡼ− 159 −

第1日

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日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 29㇟∳㉁᥋╔࡟࠾ࡅࡿNaOCl࡜ࢫࣝࣇ࢕ࣥ㓟ሷฎ⌮
1ࢫࢸࢵࣉࢩࢫࢸ࣒ࡢ㛗ᮇ᥋╔⬟‫ۑ‬୰㇂᪩ᕼ㸪ᓟ ⠜ྐ㸪ᯇᮏ┿⌮Ꮚ㸪ᒾୗኴ୍㸪༡㔝༟ஓ㸪ᕝཱྀ᫂᪥㤶㸪ᮾ ┿ᮍ୕ᾆ἞㑻*㸪▮㇂༤ᩥ኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ ࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫศ㔝㸪*⥲ྜデ⒪㒊
Effectiveness of NaOCl and sulfinic acid sodium salt treatment on dentin-resin bonding- Long term dulability of one-step self-etching adhesive Nakatani H, Mine A, Matsumoto M, Iwashita T, Minamino T, Kawaguchi A, Higashi M
Miura J*, Yatani H
Department of Fixed Prosthodontics, Osaka University Graduate School of Dentistry*General medical treatment part, Osaka University Graduate School of DentistryϪ㸬 ⤖ᯝ࡜⪃ᐹ஧ ඖ 㓄 ⨨ ศ ᩓศ ᯒ ࡢ ⤖ ᯝ 㸪ྛ ṑ 㠃 ฎ ⌮ 㸦 <0.001, F = 23.4㸧࠾ࡼࡧಖᏑᮇ㛫㸦 = 0.008, F = 5.0㸧࡜ࡶ࡟ᙳ㡪ࡣ᭷ព࡛࠶ࡗࡓ㸬NC+AC⩌ࡢึᮇ᥋╔ᙉࡉࡣ53.3s9.7 MPa㸦meansSD㸧࡛࠶ࡾ㸪ᑐ↷⩌
㸦37.3s10.5 MPa㸧㸪NC⩌㸦38.0 s15.6MPa㸧࡟ᑐࡋ࡚᭷ព࡟㧗࠿ࡗࡓ㸦ᑐ↷:  = 0.007, NC:  =0.01㸪Shefféࡢከ㔜ẚ㍑㸧㸬ᑐ↷⩌࡜NC⩌࡜ࡢ㛫࡟ࡣ᭷ពᕪࡀ࡞࠿ࡗࡓ㸬1ᖺỈ୰ಖᏑ࡟ࡼࡾ඲⩌᥋╔ᙉࡉࡢపୗࢆㄆࡵࡓࡶࡢࡢ㸪ྛ⩌ࡢ᥋╔ᙉࡉࡣ
ྠᵝࡢഴྥ࡛࠶ࡗࡓ㸬ࡍ࡞ࢃࡕNC+AC⩌ࡀ45.8s
12.9MPa࡛࠶ࡾ㸪ᑐ↷⩌㸦28.1s11.0MPa 㸧㸪NC
⩌㸦33.0s13.4MPa㸧࡟ᑐࡋ࡚᭷ព࡟㧗࠿ࡗࡓ㸦ᑐ↷:  < 0.001, NC:  < 0.001㸪Shefféࡢከ㔜ẚ㍑㸧㸬
ᑐ↷⩌࡜NC⩌࡜ࡢ㛫࡟ࡣ᭷ពᕪࡀ࡞࠿ࡗࡓ㸬ྛ⿕╔㠃ฎ⌮ᚋࡢSEMほᐹ࡛ࡣ㸪ࣜࣥ㓟ฎ⌮࡟ϩ㸬 ᪉ἲࡼࡿࢫ࣓࢔ᒙ㝖ཤ㸪⬺⅊ࢥ࣮ࣛࢤࣥࡢ㟢ฟ㸪㇟∳ ࠺⼃ࡢ࡞࠸ࣄࢺᢤཤ኱⮻ṑ15ᮏࢆ᭱኱㇏㝯㒊࡟⣽⟶ࡢ㛤ཱྀ㸪ࡑࡋ࡚NaOClฎ⌮࡟ࡼࡿ⬺⅊ࢥ࣮࡚ࣛṑ㍈࡜ᆶ┤࡟ษ᩿ࡋ㸪ࢩࣜࢥ࣮࣮ࣥ࢝ࣂ࢖ࢻ⪏ࢤࣥࡢ㝖ཤࢆほᐹ࡛ࡁࡓࡀ㸪ࢫࣝࣇ࢕ࣥ㓟ሷฎ⌮Ỉ࣮࣌ࣃ࣮㸦㸡600㸧࡟࡚◊☻ࡋࡓṑෙ㒊㇟∳㉁ࢆ
࡟ࡼࡿ㇟∳㉁ࡢ᫂ࡽ࠿࡞ᙧែⓗኚ໬ࡣㄆࡵࡽࢀ࡞
ヨ㦂య࡜ࡋࡓ㸬㇟∳㉁⿕╔㠃ฎ⌮࡜ࡋ࡚㸪ヨ㦂య࠿ࡗࡓ㸬TEM࡟ࡼࡿᑐ↷⩌ࡢ᥋╔⏺㠃ほᐹ࡛ࡣ㸪࡟ᑐࡋ࡚15⛊㛫ࡢࣜࣥ㓟㸦K࢚ࢵࢳࣕࣥࢺ㸪ࢡࣛࢫ࣓࢔ᒙࡢṧ␃ࡀㄆࡵࡽࢀ㸪1ᖺỈ୰ಖᏑ࡟ࡼࡾ᫂
ࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧ฎ⌮ᚋ㸪NaOCl㸦ADࢤࣝ㸪ࡽ࠿࡞᥋╔⏺㠃ࡢຎ໬ࡀㄆࡵࡽࢀࡓ㸬NC⩌࠾ࡼࡧࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧࡟࡚60⛊㛫ฎ⌮ࢆ⾜ࡗ
NC+AC⩌࡛ࡣ㸪㛤ཱྀࡋࡓ㇟∳⣽⟶ෆࡢࣞࢪࣥࢱࢢ
ࡓ⩌ࢆNC⩌࡜ࡋࡓ㸬ࡲࡓ㸪NC⩌࡜ྠᵝࡢฎ⌮ᚋ࡟ࢫࣝࣇ࢕ࣥ㓟Naሷ㸦࢔ࢡࢭࣝ㸪ࢧ࣓ࣥࢹ࢕࢝ࣝ㸧 ᙧᡂࡀㄆࡵࡽࢀ㸪1ᖺỈ୰ಖᏑ࡟ࡼࡿ⏺㠃ࡢኚ໬ࡣ☜ㄆࡉࢀ࡞࠿ࡗࡓ㸬
࡛15⛊㛫ฎ⌮ࡋࡓ⩌ࢆNC+AC⩌࡜ࡋ㸪⿕╔㠃ฎ⌮௒ᅇ⏝࠸ ࡓ 1st SE ࡟࠾࠸࡚ ࡣ㸪ࣜࣥ 㓟࠾ ࡼࡧࢆ⾜ࢃ࡞࠸㇟∳㉁ࢆᑐ↷⩌࡜ࡋࡓ㸬⥆࠸࡚1st SE࡜
NaOClࢆ⏝࠸ࡓ⿕╔㠃ฎ⌮࡟ࡼࡾࢫ࣓࢔ᒙࡢ㝖ཤࢥ࣏ࣥࢪࢵࢺࣞࢪࣥ㸦SE bond ONE㸪ࢡࣜ࢔ࣇ࢕
࣐ࣝࢪ࢙ࢫࢸ࢕࣮ES-2, ࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧 ➼㸪᥋╔⬟ࢆྥୖࡉࡏࡿ࡜⪃࠼ࡽࢀࡿ㇟∳㉁ࡢᙧ
ែⓗኚ໬ࡀㄆࡵࡽࢀࡿࡶࡢࡢ㸪ึᮇ࠾ࡼࡧ㛗ᮇ᥋ࢆ⏝࠸࡚㏻ἲ࡟ᚑ࠸᥋╔᧯సࢆ⾜ࡗࡓ㸬37Υ⵨␃╔⬟ࡢྥୖࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬୍᪉㸪ࢫࣝࣇ࢕Ỉ࡟24᫬㛫Ỉ୰ᾐₕࡋࡓᚋ㸪᥋╔ヨ㦂⏝ヨᩱ㸦1ࣥ㓟ሷ࡟ࡼࡿฎ⌮ࢆຍ࠼ࡿࡇ࡜࡛㸪㇟∳㉁᥋╔⬟cm X 1 cm㸧ࢆస〇ࡋ㸪ྛ⩌࡟࠾࠸࡚ึᮇ㸪6ࣨ᭶ࡀ㛗ᮇ⪏ஂᛶࢆྵࡵ࡚ྥୖࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞
ಖᏑ࠾ࡼࡧ1ᖺಖᏑࡢࢧࣈࢢ࣮ࣝࣉ㸦ྛn=15㸧࡬↓ࡗࡓ㸬సⅭ࡟ศࡅ㸪ࡑࢀࡒࢀᚤᑠᘬᙇ᥋╔ヨ㦂ࢆ⾜ࡗࡓ㸬 ᙧែほᐹ࡜ࡋ࡚㸪ṑ㠃ฎ⌮ࡢྛࢫࢸࢵࣉ࡟࠾ࡅࡿϫ㸬 ᩥ⊩㇟∳㉁⾲㠃ࡢSEMほᐹ㸪࡞ࡽࡧ࡟ᚤᑠᘬᙇ᥋╔ヨ1㸧Prasansuttiporn T, Nakajima M, Kunawarote S  㦂࡜ྠᵝ࡟స〇ࡋࡓヨ㦂యࡢ᥋╔⏺㠃TEMほᐹࢆ
Effect of reducing agents on bond strength to⾜ࡗࡓ
NaoCl-treated dentin. Dent Mater 2011; 27: 229-34.
Ϩ㸬 ┠ⓗ⌧ᅾ᥋╔ࢩࢫࢸ࣒ࡣ⡆␎໬ࡀ㐍ࡳ㸪1ࢫࢸࢵࣉࢭ
ࣝࣇ࢚ࢵࢳࣥࢢࢩࢫࢸ࣒㸦1st SE㸧 ࡀ⮫ᗋ࡟࠾࠸࡚ከࡃ౑⏝ࡉ࡚࠸ࡿࡀ㸪ࡑࡢ᥋╔⬟ࡸ⪏ஂᛶࡀ୙༑ศ࡜ࡍࡿሗ࿌ࡀ࠶ࡿ㸬ࣜࣥ㓟࠾ࡼࡧNaOCl࡟ࡼࡿฎ⌮ࡣ1st SEࡢ᥋╔⬟ࢆྥୖࡉࡏࡿྍ⬟ᛶࡀ㧗࠸ࡶࡢࡢ㸪ࡑࡢሗ࿌ࡣᑡ࡞࠸㸬୍᪉㸪NaOClฎ⌮ᚋࡣ㓟໬≀ࡀṧᏑࡋ㔜ྜ㜼ᐖࡀ㉳ࡇࡿࡇ࡜ࡀᣦ᦬ࡉ
ࢀ㸪ࡑࡢᑐฎἲ࡜ࡋ࡚㑏ඖస⏝ࢆࡶࡘࢫࣝࣇ࢕ࣥ
㓟Naሷࢆ౑⏝ࡍࡿࡇ࡜࡛㔜ྜ㜼ᐖࢆ㜵ࡄࡇ࡜ࡀ࡛
ࡁࡿࡇ࡜ࡀ♧၀ࡉࢀ࡚࠸ࡿ1)㸬
 ࡑࡇ࡛௒ᅇ㸪1st SEࡢ㇟∳㉁᥋╔⬟ྥୖࢆ┠ⓗ࡜ࡋ࡚㸪 NaOClฎ⌮࠾ࡼࡧࢫࣝࣇ࢕ࣥ㓟ሷฎ⌮ࡢຠᯝࢆ☜ㄆࡋࡓ㸬− 160 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表

1 ─ 3 ─ 30

MDF ⣧ࢳࢱࣥࡢ≉ᛶホ౯‫Ⲩۑ‬஭భ㍜㸪ᫍ᠇ᖾ㸪ᩧ⏣∾Ꮚ㸪▼஭ᗣ㕷㸪⇃ᆏ▱ᑵ㸪ᯘᖾ⏨㸪᱔ཎ῟அ㸪୕ᾆ༤ᕫ㸪኱ஂಖຊᘅ㸪᪩ᕝᚭ㸪ᮌᮏඞᙪ

⚄ዉᕝṑ⛉኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉࿪ᄮᶵ⬟ไᚚ⿵⥛Ꮫㅮᗙ㸪㸨㇏ᶫᢏ⾡⛉Ꮫ኱Ꮫ኱Ꮫ㝔ᕤᏛ◊✲⛉㸨㸨㭯ぢ኱ᏛṑᏛ㒊᭷ᗋ⩏ṑ⿵⥛Ꮫㅮᗙ㸪㸨㸨㸨㭯ぢ኱ᏛṑᏛ㒊ṑ⛉⌮ᕤᏛㅮᗙCharacterization of pure titanium fabricated by Multi-Directional Forging
Arai Y, Hoshi N, Saita M, Ishii K, Kumasaka T, Hayashi Y, Kuwabara A, Miura H*, Ohkubo C, Hayakawa T,
Kimoto K
Department of Prosthodontics and Oral Rehabilitation, Graduate School, Kanagawa Dental University
Department of Mechanical Engineering, Toyohashi University of Technology*, Department of Removable
Prosthodontics, Tsurumi University School of Dental Medicine**, Department of Dental Engineering, Tsurumi
University School of Dental Medicine***








Ϩ㸬 ┠ⓗ ⌧ᅾ㸪ࢳࢱࣥᮦᩱࡣඃࢀࡓᮦᩱ≉ᚩ࠿ࡽ་⒪⏝ᮦᩱ࡜ࡋ࡚ᗈࡃ⏝࠸ࡽࢀ࡚࠾ࡾ㸪⿵⥛㡿ᇦ࡟࠾࠸࡚ࡶᗈࡃ⏝࠸ࡽࢀ࡚࠸ࡿ㸬ࡋ࠿ࡋ㸪⣧ࢳࢱࣥࡣຍ
ᕤᡂᙧࡀ㞴ࡋࡃᙉᗘࡀຎࡿⅬ࠿ࡽ㸪ྜ㔠໬࡞࡝ࡢ◊✲ࡸ㛤Ⓨࡀࡉࢀ࡚ࡁࡓ{Ϳ㸬ࡲࡓ㸪ࢳࢱࣥྜ㔠ࡣ㧗࠸ᙉᗘࢆᚓࡽࢀࡿ୍᪉࡛㸪⪏㣗ᛶࡸ⏕య㐺ྜᛶ࡞࡝࡛⣧ࢳࢱࣥ࡟ຎࡗ࡚࠸ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿ㸬 ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪 MDF㸦ከ㍈㘫㐀㸧ἲࢆ⏝࠸㧗ᙉᗘ໬ࡋࡓ⣧ࢳࢱࣥࡢ᭦࡞ࡿ≉ᛶࢆ᳨ウࡋࡓࡢ࡛ሗ࿌ࡍࡿ㸬ϩ㸬 ᪉ἲ
ࢳࢱࣥࣈࣟࢵࢡ㸦ᮾ㑥ࢳࢱࢽ࣒࢘♫〇㸧ࡣ㸪Grade 2 ⣧ࢳࢱࣥ㸦௨ୗ㸪⣧ࢳࢱࣥ㸧࡜㸪ࡇࢀ࡟
MDF ຍᕤ㸦௨ୗ㸪MDF ⣧ࢳࢱࣥ㸧ࡋࡓ✀㢮ࢆ⏝ពࡋ㸪ࡇࢀࢆᶵᲔⓗᛶ㉁ࡢ ᐃ࡟ࡣཌࡉ0.4 mm
ࡢヨ㦂∦㸪࠾ࡼࡧ㓟ฎ⌮⏝࡟ࡣ㸪ȭ20 mm㸪ཌࡉ
1.0 mmࡢ෇ᯈࢆヨ㦂ヨᩱ࡜ࡋࡓ㸦ᕝᮏ㔜ᕤ〇㸧㸬ᐃ㡯┠ࡣ㸪 ◳ࡉヨ㦂㸦࣐࢖ࢡࣟࣅࢵ
࣮࢝ࢫ◳ᗘィ HMV-20S Shimadzu㸪Ⲵ㔜㸸5 N㸧㸪ᘬᙇヨ㦂㸦ᓥὠ࣮࢜ࢺࢢࣛࣇ AG-X plus Shimadzu㸪ࢡࣟࢫ࣊ࢵࢻࢫࣆ࣮ࢻ㏿ᗘ 6.3 mm/min㸧ࡢ ᐃࢆ⾜ࡗࡓ㸬ࡲࡓගᏛ㢧ᚤ㙾㸦PME3 Olympus㸧࡜㟁⏺
ᨺᑕᆺ㟁Ꮚ㢧ᚤ㙾㸦JEM-2100F Jeolࠑ᪥ᮏ㟁Ꮚࠒ㸪ຍ㏿㟁ᅽ 200 kV㸧࡛⾲㠃࡜ෆ㒊ᚤ⣽ᵓ㐀ࡢほᐹࢆ⾜ࡗࡓ㸬 ࡲࡓ㸪㓟ฎ⌮࡟ࡼࡿᙳ㡪ࢆ᳨ウࡍࡿࡓࡵ࡟㸪
67㸣H΃SO΅㸪120 Υ㸪75 ⛊㛫ฎ⌮ࢆ⾜ࡗࡓ⩌㸦௨ୗ㸪㓟ฎ⌮⩌㸧㸪⾜ࢃ࡞࠸⩌㸦௨ୗ㸪ࢥࣥࢺ࣮ࣟࣝ
⩌㸧ࢆ⣧ࢳࢱࣥ࡜ MDF ⣧ࢳࢱ࡛ࣥྛࠎ6ᯛࡎࡘ⏝ពࡋ㸪⾲㠃ᵓ㐀ほᐹ࡜ࡋ࡚㸪⾲㠃⢒ࡉ࡜㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾㸦6500F Jeol㸪ຍ㏿㟁ᅽ 20 kV㸧࡟ࡼࡿ⾲㠃ほᐹ㸪ࡑࡋ࡚᥋ゐゅࡢ ᐃ㸦DCA-VZ㸪༠࿴⏺㠃⛉Ꮫ㸧ࢆ⾜ࡗࡓ㸬⤫ィฎ⌮ࡣ୍ඖ㓄⨨ศᩓศᯒ࠾ࡼࡧ Turkey ᳨ᐃࢆ⾜ࡗࡓ㸬༴㝤⋡ࡣ 5 㸣࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
 MDF ⣧ࢳࢱࣥࡢ࣐࢖ࢡࣟ Vickers ◳ࡉࡣ㸪ᖹ
ᆒ Hv 293 ࡛㸪᭱኱ᘬᙇᛂຊࡀ⣙ 1016 MPa ࡛࠶ࡗࡓ㸬ࡇࢀࡽࡢ್ࡣ㸪୍⯡ⓗ࡞⣧ࢳࢱࣥࡢ⣙ 2 ಸ௨ୖ࡛࠶ࡗࡓ㸦ᅗ1,2㸧㸬ࡲࡓࢳࢱࣥྜ㔠㸦Ti-6Al4V ྜ㔠㸧࡜ẚ࡭ࡿ࡜㸪ྠ➼௨ୖࡢᙉᗘࢆᣢࡘࡇ
࡜ࡀ♧ࡉࢀࡓ㸬ᚤど⤌⧊ほᐹ࡛ࡣ㸪MDF ຍᕤ๓ࡢ⤌⧊࡟ẚ࡭ MDF ἲ࡟ࡼࡾ⤖ᬗ⢏ࡢศ᩿࡜ᚤ⣽໬ࡀ☜ㄆ࡛ࡁࡓ㸬TEM ほᐹ࡛ࡣ㸪㉸ᚤ⢏Ꮚ㸪㧗ᐦᗘࡢ㌿఩ࢆྵࡴ㉸ᚤ⤖ᬗ⢏⤌⧊ࡀ☜ㄆࡉࢀࡓ㸬ࡲࡓไ㝈ど㔝ᅇᢡ㸦SAD㸧ീࡣ࡯ࡰࣜࣥࢢ≧࡛㸪⤌⧊ࡀᆒ୍࡞㉸ᚤ⣽⤖ᬗ⢏࡟ࡼࡗ࡚ᵓᡂࡉࢀ࡚࠸ࡿ
ࡇ࡜ࡀ♧ࡉࢀ㸪ࡑࡢᖹᆒ⤖ᬗ⢏ᚄࡣ 100 nm ௨ୗ࡛࠶ࡗࡓ㸬  㓟ฎ⌮ᚋࡢ MDF ⣧ࢳࢱࣥࡣ㸪୍⯡ⓗ࡞⣧ࢳࢱࣥࡼࡾᚤ⣽࡞ࢼࣀᵓ㐀࡜࡞ࡗ࡚࠸ࡿ஦ࡀศ࠿ࡗࡓ㸬᥋ゐゅࡣࢥࣥࢺ࣮ࣟࣝ⩌࡛MDF ⣧ࢳࢱࣥࡣ⣧ࢳࢱࣥ࡟ẚ࡭࡚᭷ព࡟␯Ỉᛶࢆ♧ࡋࡓࡀ㸪㓟ฎ⌮⩌࡛ࡣඹ࡟ 40° ⛬ᗘ࡜ぶỈ໬ഴྥ࡟ኚ໬ࢆ♧ࡋࡓ㸬 ௒ᅇ㸪MDF ἲ࡟ࡼࡿᙉࡦࡎࡳຍᕤࢆ⏝࠸ࡿࡇ࡜࡟ࡼࡾ㸪⣧ࢳࢱࣥࢆ㧗ᙉᗘ㸪ぶỈᛶഴྥࢆᣢࡓ
ࡏࡿࡇ࡜ࡀྍ⬟࡛࠶ࡿࡇ࡜࠿ࡽ㸪ṑ⛉࡟฼⏝ࡍ࡭ࡁࢳࢱࣥᮦ࡜ࡋ࡚᭷ຠ࡛࠶ࡿ࡜♧၀ࡉࢀࡓ㸬






   ᅗ Vickers ◳ࡉ    ᅗ᭱኱ᘬᙇࡾᛂຊϫ㸬 ᩥ⊩
I. Sabirov, R. Z. Valiev, I. P. Semenova, R. Pippan.
Effect of equal channel angular pressing on the fracture
behavior of commercially pure titanium. Matellurgicaland Materials Transactions A010; 41(3): 727-733.

− 161 −

第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 31⮫ᗋᩍ⫱࡟࠾ࡅࡿᶍᆺࢫ࣐࢟ࣕࣥࢵࢳࣥࢢἲࢆ⏝࠸ࡓᨭྎṑᙧែࡢホ౯࡜ᣦᑟἲࡢ᳨ウ‫ ۑ‬ᱵཎ୍ᾈ㸪ゅ಴⤀㸪୰㔝ṇ༤*㸪ᮌᮧ೺஧*㸪ᅄࢶ㇂ㆤ**㸪బ⸨஽**㸪ᯇỌᬛ***㸪
㜿㒊ఙ୍***

ᮾ໭ᨭ㒊㸪*ᮾிᨭ㒊㸪**ᮾிṑ⛉኱Ꮫࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫㅮᗙ㸪***ᮾிṑ⛉኱Ꮫゎ๗ᏛㅮᗙA new method to evaluate the preparation design of an abutment tooth using the model scan matching methodin the clinical education and examination of the instruction method.
Umehara K, Suminokura S, Nakano M*, Kimura K*, Yotsuya M**, Sato T**, Matsunaga S***, Abe S***
Tohoku Branch, *Tokyo Brunch, **Department of Crown and Bridge Prosthodontics, Tokyo Dental College,***Department of Anatomy, Tokyo Dental Collegeᨭྎṑᙧᡂ᫬࡟࠾ࡅࡿษ๐㔞ࡢ㐪࠸ࢆᖹ㠃ࡈ࡜࡟Ϩ㸬 ┠ⓗ☜ㄆࡍࡿࡇ࡜ࡀ࡛ࡁࡓ㸬ࡲࡓࣂ࣮ࢳࣕࣝညྜჾୖ Ꮫ⏕ᐇ⩦࡟࠾࠸࡚ࢡࣛ࢘ࣥᨭྎṑᙧᡂᚋࡢᨭྎ
࡛㸪ᨭྎṑᙧᡂᚋࡢᨭྎṑ࡜⌮᝿ⓗᨭྎṑᙧែࢆṑࢹࢨ࢖ࣥࢆ⩦ᚓࡉࡏࡿࡓࡵ࡟ࡣ㸪ᙧᡂᚋࡢࢹࢨ
㔜ࡡྜࢃࡏ㝈⏺㐠ືࡉࡏࡓ⤖ᯝ㸪ୗ㢡㐠ື࡟㛵୚࢖ࣥࢆホ౯ࡍࡿᚲせࡀ࠶ࡿࡀ㸪ࡑࡢᡭẁࡀᑡ࡞࠸ࡍࡿᨭྎṑᙧᡂ㠃ࢆ❧యⓗ࡟⫗║࡛☜ㄆࡍࡿࡇ࡜
ࡢࡀ⌧≧࡛࠶ࡿ 㸬௒ᅇ㸪₇⪅ࡽࡣ㸪Ꮫ⏕ࡢ⾜࡞ࡀ࡛ࡁࡓ㸬
ࡗࡓࢡࣛ࢘ࣥᨭྎṑᙧᡂࢹࢨ࢖ࣥࢆᣦᑟ࣭ᨵၿࡍ
ࡿ┠ⓗ࡛㸪ᶍᆺࢫ࣐࢟ࣕࣥࢵࢳࣥࢢࡋࡓࢹ࣮ࢱࢆ㸪  Ꮫ⏕ࡢᨭྎṑᙧᡂᐇ⩦࡛స〇ࡉࢀࡿᨭྎṑᙧែ࡟ࡣಶேᕪࡀ࠶ࡾ㸪㐣ᙧᡂࡉࢀࡓᨭྎṑࢆ⌮᝿ⓗ&$'&$0ࢯࣇࢺୖ࡛㔜ࡡྜࢃࡏ㸪⮫ᗋᩍ⫱ᐇ⩦ᛂ⏝ᨭྎṑᙧែ࡟㏆࡙ࡃࡼ࠺ಟṇ㸪ᣦᑟࡍࡿࡇ࡜ࡣ㞴ࡋ㸪Ⰻዲ࡞ຠᯝࢆᚓࡓࡢ࡛ሗ࿌ࡍࡿ㸬ࡋ࠸㸬ࡋ࠿ࡋ௒ᅇ㸪ᙧᡂᚋࡢᨭྎṑࢆཱྀ⭍ෆࢫ࢟ࣕࢼࢆ౑⏝ࡋ࡚ࢫ࢟ࣕࣥࡍࡿࡇ࡜࡛㸪⡆༢࡟ḟඖϩ㸬 ᪉ἲ໬ࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡗࡓ㸬ࡲࡓ&$'&$0ࢯࣇࢺୖ ᨭྎṑࡣ㸪ᮾிṑ⛉኱ᏛᏛ⏕ᐇ⩦࡛⏝࠸࡚࠸ࡿ࡛ࡢ㔜ࡡྜࢃࡏࡸ'ࣉࣜࣥࢱฟຊ࡟ࡼࡿ❧యⓗ⾲ࢡࣛ࢘ࣥᨭྎṑᙧᡂᐇ⩦⏝ṑ∳ࣔࢹࣝ㸦ࢽࢵࢩࣥ♧ࡣ㸪ᨭྎṑᙧᡂᚋࡢ㍈㠃ࡸࢡࣜ࢔ࣛࣥࢫࢆ☜ㄆ㸪♫〇㸧ࡢୖ㢡➨୍ᑠ⮻ṑ࡛㸪࣮࢜ࣝࢭ࣑ࣛࢵࢡࢡ
ࣛ࢘ࣥࢆస〇ࡍࡿ┠ⓗ࡛㸪Ꮫ⏕ࡀᨭྎṑᙧᡂࡋࡓ㸬 ࣇ࢕࣮ࢻࣂࢵࢡࡍࡿࡇ࡜ࡀ࡛ࡁ㸪≉ู࡞ホ౯ࢯࣇࢺࢆ⏝࠸ࡿࡇ࡜࡞ࡃ㸪Ꮫ⏕ಶேࡢᨭྎṑᙧᡂࡢ≉ṑิᶍᆺࢫ࣐࢟ࣕࣥࢵࢳࣥࢢࡢ㔜ࡡྜࢃࡏࢆ⾜࡞࠺┠ⓗ࡛㸪ཱྀ⭍ෆࢫ࢟ࣕࢼ࣮75,26㸦㸱6KDSH♫〇㸧 ᚩࢆホ౯ࡍࡿࡇ࡜ࡀ࡛ࡁࡓ㸬 ᮏࢩࢫࢸ࣒ࢆ⏝࠸ࡿࡇ࡜࡛㸪Ꮫ⏕ࡣ⌮᝿ⓗ࡞ᨭࢆ⏝࠸࡚ᙧᡂᚋࡢᨭྎṑࢆࢫ࢟ࣕࣥࡋ㸪67/ࢹ࣮ࢱྎṑᙧែࢆࡼࡾ᪩ࡃ⩦ᚓࡍࡿࡇ࡜ࡀྍ⬟࡜࡞ࡾ㸪໬ࡋ࡚㸪&$'&$0ࢯࣇࢺ6KDSH'HQWDO'LVLJQHU⮫ᗋᩍ⫱ᐇ⩦࡟ຠᯝⓗ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬
3UHPLXP㸦6KDSH♫〇㸧࡟ྲྀࡾ㎸ࢇࡔ㸬ࡲࡓྠᵝ࡟㸪ᨭྎṑᙧᡂ๓ࡢேᕤṑࣔࢹࣝ࠾ࡼࡧ⌮᝿ϫ㸬 ᩥ⊩ⓗᙧែ࡟ᙧᡂࡉࢀࡓᨭྎṑࣔࢹࣝࢆࢫ࢟ࣕࣥࡋ㸪1) ⏣ཱྀ⿱ဢ㸪⁪ἑᬛᏊ㸪ᒸ཭᭷Ꮚ࡯࠿㸬඲㒊㗪ࢯࣇࢺୖ࡛㸱ࡘࡢࢹ࣮ࢱࢆ㔜ࡡྜࢃࡏࡓ㸬㔜ࡡྜ㐀ෙᨭྎṑᙧᡂࡢᢏ⾡ᩍ⫱࡜ᐈほⓗホ౯࡟㛵ࢃࡏࡓ⏬ീࢆᖹ㠃࠿ࡽホ౯ࡋ㸪ᙧᡂᚋࡢᨭྎṑᙧࡍࡿ᪂ࡓ࡞ヨࡳ㸬⿵⥛ㄅ 2012㸹4. 434-443㸬ែࡀ⌮᝿ⓗ࡞ᨭྎṑᙧែ࡜࡝ࡢࡼ࠺࡟㐪ࡗ࡚࠸ࡿ2) 㜿㒊ಇᐉ㸪ዟᒣᘺ⏕㸪➟ཎ⤀࡯࠿㸬ࢥࣥࣆࣗ࠿ほᐹࡋ㸪ಟṇࡍ࡭ࡁⅬࢆᣦᑟࡋࡓ㸬࣮ࢱ࣮ࢢࣛࣇ࢕ࢵࢡࢆే⏝ࡋࡓࣇ࢕࣮ࢻࣂࢵ
ࡲࡓ㸪㝈⏺㐠ື᫬ࡢࢡࣜ࢔ࣛࣥࢫࢆホ౯ࡍࡿ┠ࢡࡀᨭྎṑᙧᡂ࡟୚࠼ࡿᩍ⫱ຠᯝ㸬⿵⥛ㄅⓗ࡛㸪ᙧᡂᚋࡢᨭྎṑᙧែ࡜⌮᝿ⓗ࡞ᨭྎṑᙧែ
2009㸹1. 123-129㸬ࢆ㔜ࡡྜࢃࡏ㸪ࣂ࣮ࢳࣕࣝညྜჾୖ࡛ホ౯ࡋࡓ㸬   ࡉࡽ࡟㸪Ꮫ⏕ࡀ⮬㌟ࡀᙧᡂࡋࡓᨭྎṑᙧែ࡜⌮᝿ⓗᨭྎṑᙧែࡢ㐪࠸ࢆ☜ㄆࡋࣇ࢕࣮ࢻࣂࢵࢡࡍ
ࡿ┠ⓗ࡛㸪Stratasys♫〇OBJET260 Connexࢆ⏝࠸࡚㸪ᨭྎṑᙧᡂᚋ࡜⌮᝿ⓗ࡞ᨭྎṑᙧᡂࢹࢨ࢖ࣥࡢⰍ
ࢆኚ࠼࡚'ࣉࣜࣥࢱ࡟࡚ฟຊࡋ㸪❧యⓗ࡟⾲♧ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᮏᐇ⩦࡛⏝࠸ࡓᨭྎṑᙧᡂ๓ᚋࡢᨭྎṑ࠾ࡼࡧ⌮᝿ⓗᨭྎṑᙧែࢆࢯࣇࢺୖ࡛㔜ࡡྜࢃࡏࡓ⤖ᯝ㸪

− 162 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 32Ꮫ⏕ᐇ⩦࡟࠾ࡅࡿࢹࢪࢱࣝࢹ࣮ࢱࢆά⏝ࡋࡓᨭྎṑᙧᡂࡢᐈほⓗホ౯
‫ۑ‬ᑠ⇃ࡦࢁࡳ㸪⋢⏣ὈႹ㸪㰺⸨⿱⨾Ꮚ㸪⏣㑓᠇ᫀ㸪㔠ᮧΎᏕ㸪Ṋ㒊⣧㸪㏆⸨ᑦ▱ᒾᡭ་⛉኱ᏛṑᏛ㒊⿵⥛࣭࢖ࣥࣉࣛࣥࢺᏛㅮᗙ
Objective assessment of the tooth preparation training by digital data in student training
Oguma H, Tamada Y, Saito Y, Tanabe N, Kanemura K, Takebe J, Kondo H
Department of prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical UniversityϨ㸬 ┠ⓗࡇࢀࡲ࡛㸪ࢥࣥࣆ࣮ࣗࢱ࣮ࢢࣛࣇ࢕ࢵࢡࢆ⏝࠸ࡓᨭྎṑᙧᡂࡢᩍ⫱ຠᯝࡀ᳨ドࡉࢀ㸪ࡑࡢ᭷⏝ᛶࡀ♧ࡉࢀ࡚࠸ࡿ 1 㸧 㸬୍᪉㸪ᩍဨ㸪Ꮫ⏕ࡀ௵ព࡟ᅇ
㌿㸪ᣑ኱ྍ⬟࡞3D⏬ീࢆ⏝࠸ࡓሙྜࡢᨭྎṑᙧᡂᐇ⩦࡟࠾ࡅࡿᩍ⫱ຠᯝ࠾ࡼࡧホ౯࡟㛵ࡍࡿሗ࿌ࡣ
ᮍࡔ࡞࠸㸬᫖௒㸪㛤Ⓨࡀ㐍ࢇ࡛࠸ࡿཱྀ⭍ෆࢫ࢟ࣕࢼ࣮࡟ࡼ
ࡗ࡚ᚓࡽࢀࡓ3D⏬ീࡣ㸪ࣔࢽࢱ࣮ୖ࡛ࣂ࣮ࢳࣕࣝ
࣡ࢵࢡࢫ࢔ࢵࣉࡀ༶ᗙ࡟⾜࠼㸪ᨭྎṑᙧᡂ࡟࠾࠸
࡚㐺ษ࡞๐㝖㔞ࡀᚓࡽࢀ࡚࠸ࡿ࠿ࢆ☜ㄆ࡛ࡁࡿࡇ
࡜࠿ࡽ෌⌧ᛶࡢ㧗࠸ホ౯ࡀྍ⬟࡜࡞ࡗ࡚࠸ࡿ㸬ᮏ◊✲࡛ࡣ㸪ᚑ᮶ἲ࡟ࡼࡿᨭྎṑᙧᡂࡢ୺ほⓗホ౯࡜ᨭྎṑᙧᡂホ౯ᨭ᥼ࢯࣇࢺ࡟ࡼࡿホ౯ࡢ⤖ᯝࢆẚ㍑᳨ウࡋ㸪ྛホ౯ἲ࡟࠾ࡅࡿၥ㢟Ⅼࡢᢳฟࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ᒾᡭ་⛉኱ᏛṑᏛ㒊ࡢᖹᡂ26ᖺᗘ➨4ᏛᖺࡢᏛ⏕53ྡ㸦⏨ᛶ31ྡ㸪ዪᛶ22ྡ㸪ᖹᆒᖺ㱋23.9s3.1ṓ㸧ࢆᑐ㇟࡜ࡋ㸪ṑᏛ㒊➨4ᏛᖺFinal Restorationࢥ࣮ࢫࡢෙᶫ⩏ṑ⿵⥛Ꮫᐇ⩦࡟࠾࠸࡚㸪ୗ㢡ྑഃ➨୍኱⮻ṑࡢ඲㒊㔠ᒓෙࡢᨭྎṑᙧᡂヨ㦂ࢆᐇ᪋ࡋࡓ㸬1. ཱྀ ⭍ ෆ ࢫ ࢟ ࣕ ࢼ ࣮ 㸦 CEREC Omnicam® 㸪
SIRONA dental systems, USA㸧 ࢆ⏝࠸࡚㸪ᮍᙧᡂࡢேᕤṑ࠾ࡼࡧᙧᡂࡋࡓᨭྎṑࡢගᏛ༳㇟᥇ᚓࢆ⾜ࡗࡓ㸬ගᏛ༳㇟᥇ᚓ๓࡟ࡣ㸪㏻ἲ࡟ᚑ࠸ṑ⫗ᅽ᤼ࢆ⾜ࡗࡓ㸬ᚓࡽࢀࡓ⏬
ീࢹ࣮ࢱࡣRSTᙧᘧ࡛ಖᏑࡋࡓ㸬ಖᏑࡋࡓ⏬ീࢹ࣮ࢱࢆᨭྎṑᙧᡂホ౯⏝ࢯࣇࢺș∧㸦prepCheck®㸪SIRONA dental systems㸧ୖ࡛㸪ᮍᙧᡂṑ࡜ᨭྎṑࢆ㔜ࡡྜࢃࡏ㸪㍈㠃ࡢゅᗘ㸪๐㝖㔞㸪࢔ࣥࢲ࣮࢝ࢵࢺࡢ᭷↓࡟ࡘ࠸࡚ホ౯ࡋࡓ㸦ࢹࢪࢱࣝἲ㸦ᅗ㸧㸧㸬
2. ᪉ἲ1࡜ྠᵝࡢ㡯┠࡟ࡘ࠸࡚ᩘྡࡢᩍဨࡀホ౯ᇶ‽ࢆࡍࡾ࠶ࢃࡏࡓୖ࡛ホ౯ࢆᐇ᪋ࡋࡓ
㸦ᚑ᮶ἲ㸧㸬
3. ᚑ᮶ἲ࡜ࢹࢪࢱࣝἲ࡟ࡼࡿホ౯ࡢ⤖ᯝ࡟ࡘ࠸࡚⤫ィᏛⓗ࡟ẚ㍑ࡋ㸪ၥ㢟Ⅼ࡞ࡽࡧ࡟ホ౯ࡢᐈほᛶ࡟ࡘ࠸᳨࡚ウࡋࡓ㸬2⩌㛫ࡢ⤫ィ࡟ ࡣ student t-test 㸪 3 ⩌ 㛫 ࡛ ࡣ one-way
ANOVA࡜post-hoc test ࡟Tukey’s testࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1. 53ࢣ࣮ࢫ୰㸪12ࢣ࣮ࢫ࡛ᙧᡂ࡟୙ഛ㸦ṑ⫗
⦕ୗ0.5 mm௨ୖࡢᙧᡂ㸪㞄᥋㠃ࡢᙧᡂ㔞୙㊊➼㸧ࡢࡓࡵࢫ࢟ࣕࣥࡶࡋࡃࡣホ౯ࡀ୙ྍ⬟࡛࠶ࡗࡓ㸬
2. ᚑ᮶ἲ࡛㧗ホ౯ࡢሙྜ㸪㍈㠃ࡢࢸ࣮ࣃ࣮ࡢ
ᖹᆒࡣ13.4s3.4 ᗘ࡛࠶ࡾ㸪ᣦᑟ┠Ᏻ࡛࠶ࡿ2-5 ᗘࡼࡾ኱ࡁ࠿ࡗࡓ㸬3. ညྜ㠃ࡢ๐㝖㔞ࡣᖹᆒ0.8 mm⛬ᗘ࡛࠶ࡾ㸪ホ౯࡟㛵ࢃࡽࡎ୙㊊ࡋ࡚࠸ࡿഴྥ࡟࠶ࡗࡓ㸬    ホ౯࡟⏝࠸ࡓᨭྎṑࡢ㢋⯉᩿⏬ീᚑ᮶ἲ࡛ࡣ㸪㍈㠃ࡢࢸ࣮ࣃ࣮ࡀ⦆࠸ሙྜ࡟㧗ホ౯࡜࡞ࡿഴྥࡀ࠶ࡾ㸪ᇶᮏⓗ࡞ᨭྎṑࡢᙧែࡼࡾ
ࡶ⮫ᗋⓗ࡟ࢡࣛ࢘ࣥࡀ⿦╔࡛ࡁࡿ࠿ྰ࠿࡟‽ᣐࡋࡓホ౯ࡀ⾜ࢃࢀࡓࡇ࡜ࡣᚑ᮶ἲࡢၥ㢟Ⅼ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿ㸬୍᪉࡛㸪ཱྀ⭍ෆࢫ࢟ࣕࢼ࣮࠾ࡼࡧᑓ
⏝ࢯࣇࢺࢆ⏝࠸ࡓホ౯ἲࡣ㸪ᚑ᮶ἲ࡟ほࡽࢀࡿࡼ࠺࡞೫ࡾࡀᑠࡉࡃ㸪ࡼࡾᐈほᛶࡀ㧗࠸ࡇ࡜ࡀ♧၀
ࡉࢀࡓ㸬
ϫ㸬 ᩥ⊩
1) 㜿㒊ಇᐉ㸪ዟᒣᘺ⏕㸪➟ཎ⤀࡯࠿㸬ࢥࣥࣆ࣮ࣗࢱ࣮ࢢࣛࣇ࢕ࢵࢡࢆే⏝ࡋࡓࣇ࢕࣮ࢻࣂࢵ
ࢡࡀᨭྎṑᙧᡂ࡟୚࠼ࡿᩍ⫱ຠᯝ㸬᪥⿵⥛఍
ㄅ 2009㸹1㸸123-129㸬

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第1日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表1 ─ 3 ─ 33ᦤ㣗ᄟୗ㞀ᐖ࡟ᑐࡍࡿ⯉᥋ゐ⿵ຓᗋࡢ⮫ᗋⓗຠᯝ➨㸯ሗ PAPయ㦂ᐇ⩦⏝⿦⨨ࡢ㛤Ⓨ‫ۑ‬㣤⏣㈗ಇ㸪᳜⏣⪔୍㑻*㸪⋢⨨຾ྖ⚄ዉᕝṑ⛉኱Ꮫ㢡ညྜᶵ⬟ᅇ᚟⿵⥛་Ꮫㅮᗙ㸪*᪥ᮏ኱ᏛṑᏛ㒊ᦤ㣗ᶵ⬟⒪ἲᏛㅮᗙ
Clinical effect of palatal augmentation prosthesis for dysphagia treatment-Part 1- The development of the device for learning through experience about PAP
Iida T, Ueda K*, Tamaki K
Department of Prosthodontic dentistry for function of TMJ and Occlusion, Kanagawa Dental University,*Department of Dysphagia Rehabilitation, Nihon University School of DentistryϨ㸬 ┠ⓗ ᖹᡂ22ᖺ࡟ᦤ㣗ᶵ⬟ᨵၿࡢࡓࡵࡢ⿵⥛⿦⨨࡛࠶ࡿ ⯉ ᥋ ゐ ⿵ ຓ ᗋ (palatal augmentation prosthesis;
PAP) ࡀಖ㝤㐺ᛂ࡜࡞ࡗࡓ㸬ࡋ࠿ࡋᏛ⏕ᐇ⩦࡟࠾ࡅ
ࡿPAPࡢ〇స࣭య㦂ᐇ⩦࡟ࡘ࠸࡚ࡢሗ࿌ࡣ࡯࡜ࢇ࡝
Ꮡᅾࡋ࡞࠸㸬PAPࡢ〇స࡟࠾࠸࡚ࡣᦤ㣗ᄟୗ㞀ᐖ㸪≉࡟ཱྀ⭍ᮇ㞀ᐖ㸦ཱྀ⭍࠿ࡽဗ㢌࡬ࡢ㏦ࡾ㎸ࡳ㞀ᐖ㸧࡬ࡢ⌮ゎࡀ୙ྍḞ࡛࠶ࡿ1)㸬ࡑࡇ࡛㸪௒ᅇ೺ᖖ⪅࡟ᑐࡋཱྀ࡚⭍ᮇᦤ㣗ᄟୗ㞀ᐖࢆ␲ఝయ㦂࡛ࡁ㸪ࡉࡽ࡟PAPࡢຠᯝࢆయ㦂ࡍࡿࡇ࡜ࡀ࡛ࡁࡿPAPయ㦂ᐇ⩦⏝⿦⨨ࡢ㛤Ⓨࢆヨࡳࡓࡢ࡛ሗ࿌ࡍࡿ㸬ϩ㸬 ᪉ἲ ⿕㦂⪅ࡣṇᖖṑิࢆ᭷ࡍࡿ೺ᖖ⏨ᛶᡂே1ྡ㸬ୖ㢡༳㇟᥇ᚓᚋ㸪సᴗ⏝ᶍᆺࢆస〇ࡋ࣐࢘ࢫࣆ࣮ࢫ
(࢚ࣝࢥࣇࣞࢵࢡࢫ㸪࢚ࣝࢥࢹࣥࢺ♫) ࢆసࡾ㸪ࡑࡢ⮻ṑ㒊ညྜ㠃࡟5mmࡢࣃࣛࣇ࢕ࣥ࣡ࢵࢡࢫࣉࣞ
࣮ࢺࢆ↝ࡁ௜ࡅ㸪ࡉࡽ࡟ᕥྑࡢ➨୍ᑠ⮻ṑ࣭➨୍኱⮻ṑ㛫ࢆࡑࢀࡒࢀᶫΏࡋࡍࡿࡼ࠺࡟㸪Წ≧ࡢᮌ∦ࢆタ⨨ࡋ⯉㐠ື㞀ᐖయ㦂⏝࣐࢘ࢫࣆ࣮ࢫ
(Mousepiece as Impairment Simulatior for Lingual
Action; MISLA) ࢆస〇ࡋࡓ㸬࣐࢘ࢫࣆ࣮ࢫ⿦╔๓
(PreM) ࡜⿦╔ᚋ࡛㸪ᄟୗ㐀ᙳ᳨ᰝ 㸦ᅗ㸧࡟࡚ᄟୗᶵ⬟ホ౯㸦Ⓨኌ㸪✵ᄟୗ㸪10mlᄟୗ㸧࠾ࡼࡧ࣐ࣀ
࣓ࢺ࣮ࣜࢆ⏝࠸ࡓᄟୗᅽ᳨ᰝࢆ࠾ࡇ࡞࠸㸪ཱྀ⭍㏻㐣᫬㛫 (Oral Transit Time; OTT)㸪ᄟୗ᫬㣗㐨ධཱྀ㒊ᅽ㸪ཱྀ⭍ෆṧ␃㔞㸪Ⓨヰ᫂░ᗘࢆホ౯ࡋࡓ㸬ࡑࡢᚋ㸪࣐࢘ࢫࣆ࣮ࢫཱྀ⵹㒊࡟ᙧᡂᮦᩱࢆ⠏┒࣭⯉ᶵ
⬟༳㇟ࡋPAP࡟ᨵ㐀ࡋࡓ㸬PAPࢆ⿕㦂⪅࡟⿦╔ࡋ㸪
PAP๓࡜ྠᵝࡢ᳨ᰝࢆ࠾ࡇ࡞ࡗࡓ㸬PreM㸪MISLA⿦╔᫬㸪PAP⿦╔᫬࡛⤖ᯝࢆẚ㍑ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ MISLA⿦╔᫬ࡣPreM࡜ẚ࡭࡚OTTࡀᘏ㛗㸪ᄟୗ᫬㣗㐨ධཱྀ㒊᭱኱ᅽࡀపୗ㸪ᄟୗ཯ᑕច㉳᫬㛫ࡀᘏ㛗㸪ཱྀ⭍ෆṧ␃ࡀቑຍࡋ㸪Ⓨヰ᫂░ᗘࡀపୗࡋ
ࡓ㸬PAP⿦╔᫬ࡣMISLA⿦╔᫬࡜ẚ࡭࡚㸪OTTࡀ▷⦰㸪ᄟୗ᫬㣗㐨ධཱྀ㒊᭱኱ᅽࡀቑຍ㸪ᄟୗ཯ᑕច
㉳᫬㛫ࡀ▷⦰㸪ཱྀ⭍ෆṧ␃ࡀῶᑡࡋ㸪Ⓨヰ᫂░ᗘࡀྥୖࡋࡓ㸬୰ᮧࡽࡣᐇ㦂ⓗ࡟ညྜᣲୖࡍࡿࡇ࡜

࡟ࡼࡾᄟୗ᫬⯉㦵ୖ➽⩌ࡢ⯉ᅽⓎ⌧ࣃࢱ࣮ࣥࡀኚࢃࡿ஦ࢆⓎぢࡋ㸪PAP࡟ࡼࡗ࡚ᨵၿࡍࡿࡇ࡜ࢆ᫂ࡽ
࠿࡟ࡋࡓ2)㸬௒ᅇࡣࡉࡽ࡟⯉๓᪉㒊࡜ዟ⯉࡟┦ᙜࡍࡿཱྀ⵹㒊┤ୗ࡟㞀ᐖ≀ࢆタ⨨ࡍࡿࡇ࡜࡟ࡼࡾ㸪ேᕤⓗ࡟⯉ᣲୖ୙඲ࢆసࡾฟࡋࡓ㸬௨ୖࡼࡾMISLA⿦╔࡟ࡼࡿᦤ㣗ᄟୗ㞀ᐖ㸦ཱྀ⭍ᮇ㞀ᐖ㸧ࡢ␲ఝయ㦂࡟ᡂຌࡋ㸪ࡲࡓࡑࢀࢆPAP࡟ᨵ㐀ࡍࡿࡇ࡜࡟ࡼࡗ
࡚ᄟୗ࣭ᵓ㡢ᶵ⬟ᨵၿࡀㄆࡵࡽࢀࡓ㸬௨ୖࡼࡾPAPయ㦂ᐇ⩦⏝⿦⨨ࡢ㛤Ⓨ࡟ᡂຌࡋࡓ㸬ᮏ⿦⨨ࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡗ࡚͆࠸࠿࡟ṑ⛉⿵⥛≀ࡀ㣗࡭ࡿᶵ⬟࡟ᐤ୚࡛ࡁࡿ࠿͇ࢆ೺ᖖேࡀయឤ࡛ࡁࡿࡔࢁ࠺㸬⯉㐠ື㞀ᐖయ㦂⏝࣐࢘ࢫࣆ࣮ࢫ⿦╔᫬ᄟୗ㐀ᙳ᳨ᰝ⏬ീ㸦10ml ࣂ࣒ࣜ࢘Ỉ⁐ᾮᄟୗ㸧௒ᚋࡣᐇ⩦ࣉࣟࢢ࣒ࣛࢆసᡂࡋᐇ㝿࡟Ꮫ⏕ᐇ⩦ࢆࡋ࡚ຠᯝ᳨ドࢆ࠾ࡇ࡞ࡗ࡚࠸ࡃணᐃ࡛࠶ࡿ㸬ϫ㸬 ᩥ⊩1) ᳜⏣⪔୍㑻㸪ྥ஭⨾ᜨ㸪᳃⏣Ꮫ࡯࠿㸬ᦤ㣗࣭ᄟୗ㞀ᐖ࡟ᑐࡍࡿ⯉᥋ゐ⿵ຓᗋࡢ᭷ຠᛶ㸪᪥ᮏᦤ㣗ᄟୗࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍㞧ㄅ.
2012;16(1):32-41.
2) ୰ᮧಇ௓㸪ྂᒇ⣧୍㸪ᑠ㔝㧗⿱࡯࠿㸬ᐇ㦂ⓗ࡞ᅛ᭷ཱྀ⭍ࡢᣑ኱࡟ᑐࡍࡿཱྀ⵹ᗋࡢ⿦╔ࡀᄟୗ᫬⯉ཱྀ⵹᥋ゐ࡟ཬࡰࡍᙳ㡪㸪᪥ᮏᦤ㣗ᄟୗࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ఍㞧ㄅ. 2011;15(3):27483.

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日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表1 ─ 3 ─ 34ୗ㢡↓ṑ㢡ࡢ࢖ࣥࣉࣛࣥࢺ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕ࡟࣑ࢽ࢖ࣥࣉ
ࣛࣥࢺࢆే⏝ࡋࡓ୍⑕౛
‫ۑ‬ᓊᮏ‶㞝኱ศᕷ㛤ᴗ ᓊᮏṑ⛉ ஑ᕞᨭ㒊A Case Report :A Mandibular Implant Overdenture with mini-implants
Kishimoto M
Oita City
KISHIMOTO DENTAL OFFICE㸪Kyushu BranchϨ㸬 ┠ⓗ ୗ㢡↓ṑ㢡㞴⑕౛࡟࢖ࣥࣉࣛࣥࢺ࣮࢜ࣂ࣮ࢹࣥ
ࢳ࣮ࣕࢆస〇ࡍࡿ㝿㸪࢖ࣥࣉࣛࣥࢺࡢචⲴᮇ㛫୰㸪࢖ࣥࣉࣛࣥࢺ࡟㈇Ⲵࢆ୚࠼࡞࠸ࡓࡵ࡟ࡑࡢᮇ㛫⩏ṑࢆࡣࡎࡋࡓࡲࡲ࡟ࡋ࡚࠾ࡃࡇ࡜ࡣ࡛ࡁ࡞࠸㸬ࡑࢀ࡛࢖ࣥࣉࣛࣥࢺᇙධᚋ࣑ࢽ࢖ࣥࣉࣛࣥࢺࢆᇙධ
ࡋ⩏ṑࡢ⥔ᣢ⿦⨨࡜ࡋ࡚౑⏝ࡋࡓ㸬⌧ᅾࡶⰋዲ࡟
ᶵ⬟ࡋ࡚࠸ࡿࡢ࡛ࡑࡢ୍⑕౛࡟ࡘ࠸࡚ሗ࿌ࡍࡿ(ᅗ)㸬ϩ㸬 ⑕౛ ᝈ⪅㸸⏨ᛶ㸪ึデ᫬55ṓ㸪఍♫ဨ㸬ึデ᫬㸸2006ᖺ4᭶㸬୺ッ㸸ୖୗ㢡ࡢ⩏ṑస〇㸬἞⒪⤒㐣㸸2006ᖺ4᭶㸸17㸪15㸪14࡟ࡣ๓་࡟ࡼࡾ࢖ࣥࣉࣛ
ࣥࢺࡀᇙධࡉࢀࢸ࣏࣮ࣥࣛࣜࢡࣛ࢘ࣥࡀ⿦╔ࡉࢀ࡚࠸ࡓ㸬ୗ㢡࡟ࡶ௬ࡢ⥲⩏ṑࡀ⿦╔ࡉࢀ࡚࠸ࡓ㸬
2006ᖺ5᭶㸸ୖ㢡࡟ᒁ㒊ᗋ⩏ṑ㸪ୗ㢡࡟⥲⩏ṑࢆస〇⿦╔㸬
2006ᖺ6᭶㸸46㸪43㸪33㸪36ࡢ㒊఩࡟࢖ࣥࣉࣛࣥ
ࢺࢆᇙධࡋࡓ㸬ࣜࣉࣞ࢖ࢫࢭࣞࢡࢺ㸡3.5ࢆ౑⏝㸬
2006ᖺ7᭶㸸42㸪41㸪31㸪32ࡢ㒊఩࡟MDI࣑ࢽ࢖ࣥࣉࣛࣥࢺࢆᇙධࡋࡓ㸬
2006ᖺ9᭶㸸46㸪43㸪33㸪36࡟ࣄ࣮ࣜࣥࢢ࢔ࣂࢵ
ࢺ࣓ࣥࢺࢆ⿦╔ࡋࡓ㸬1㸧
2007ᖺ2᭶㸸46㸪43㸪33㸪36࡟࢔ࣂࢵࢺ࣓ࣥࢺࢆ
⿦╔ࡋࡓ㸬ᮏ⑕౛࡛ࡣ☢ᛶ࢔ࢱࢵࢳ࣓ࣥࢺࢆ฼⏝ࡋࡓ㸬2007ᖺ4᭶㸸ୖୗ㢡᭱⤊⩏ṑࢆ⿦╔ࡋࡓ㸬
2007ᖺ5᭶㸸㹋㹂㹇࣑ࢽ࢖ࣥࣉࣛࣥࢺࡣⰋዲ࡟ᶵ
⬟ࡋ࡚࠾ࡾ௚ࡢ࢖ࣥࣉࣛࣥࢺࡢ㈇ᢸࢆ㍍ࡃࡍࡿࡓࡵ࡟࠶ࡗࡓ࡯࠺ࡀࡼ࠸࡜⪃࠼ࡑࡢࡲࡲ࡟ࡋ᭱⤊⩏ṑ࡟ࣁ࢘ࢪࣥࢢࢆ⿦╔ࡋࡓ㸬௨ᚋᐃᮇⓗ࡟⤒㐣ࢆほᐹࡋ࡚ࡁࡓࡀ㸪2014ᖺ࠿ࡽ᮶㝔ࡀ㏵ษࢀࡀࡕ࡟
࡞ࡗ࡚࠸ࡓ㸬

࡛ࡑࢀ࡟ᑐᛂࡋ࡚࠸ࡿ㸬௚ࡣၥ㢟࡞ࡃⰋዲ࡟⤒㐣ࡋ࡚࠸ࡿ㸬ᮏ⑕౛࡛ࡣ࢖ࣥࣉࣛࣥࢺ࡟ࣄ࣮ࣜࣥࢢ
࣮࢝ࣛࢆ⿦╔ࡍࡿ஧ḟ㹍㹎ࡲ࡛࣑ࢽ࢖ࣥࣉࣛࣥࢺ
ࡣᬻ㛫ⓗ࡟ᶵ⬟࡛ࡁࢀࡤⰋ࠸࡜⪃࠼㸪ࡑࢀ௨㝆ࡣ㝖ཤࡍࡿணᐃ࡛࠶ࡗࡓ㸬࡜ࡇࢁࡀ᭱⤊⩏ṑ⿦╔ᚋࡶ࣑ࢽ࢖ࣥࣉࣛࣥࢺࡀⰋዲ࡟ᶵ⬟ࡋ࡚࠸ࡿࡢ࡛࠶
࠼࡚㝖ཤࡏࡎ࣓࢖ࣥࡢ࢖ࣥࣉࣛࣥࢺ࡜ే⏝ࡋ࡚࠸ࡿ㸬௒ᚋࡣୖୗ㢡㔠ᒓᗋࢆ᪂〇ࡋ࡚46ࡢ㒊఩ࡢ⿵ᙉ㸪43࢖ࣥࣉࣛࣥࢺయ࿘ᅖࡢ㦵྾཰࡟ᑐᛂࡋ࡚࠸
ࡃணᐃ࡛࠶ࡿ㸬୍⯡ⓗ࡟࢖ࣥࣉࣛࣥࢺ࡜ే⏝ࡋࡓ࣑ࢽ࢖ࣥࣉࣛ
ࣥࢺ࡟ࡘ࠸࡚ࡣ௨ୗࡢ฼Ⅼࡀ⪃࠼ࡽࢀࡿ㸬༶᫬Ⲵ㔜ࡀ࠿ࡅࡽࢀࡿࡓࡵᇙධᚋࡍࡄ࡟⩏ṑࢆ౑⏝࡛ࡁࡿ㸬ညྜᅽࢆ࣑ࢽ࢖ࣥࣉࣛࣥࢺࡀࡍ࡭࡚㈇ᢸࡍࡿ
ࡢ࡛㦵ෆ࢖ࣥࣉࣛࣥࢺ࡟వศ࡞㈇ᢸࡀ࠿࠿ࡽ࡞࠸㸬࣓࢖ࣥࡢ࢖ࣥࣉࣛࣥࢺࡢ࢜ࢵࢭ࢜࢖ࣥࢸࢢ࣮ࣞࢩ
ࣙࣥࡀ☜❧ࡉࢀࡿࡲ࡛ࡶ࡚ࡤⰋ࠸㸬ୖ㒊ᵓ㐀⿦╔ᚋ㸪ືᦂࢆࡁࡓࡏࡤ࠸ࡘ࡛ࡶᢤཤ࡛ࡁࡿ㸬࣑ࢽ࢖ࣥࣉࣛࣥࢺࡣⰋዲ࡟ᶵ⬟ࡋ࡚࠸ࡿϫ㸬 ᩥ⊩1) ᓊᮏ‶㞝㸬࢖ࣥࣉࣛࣥࢺ࡜☢ᛶ࢔ࢱࢵࢳ࣓ࣥ
ࢺࢆ฼⏝ࡋࡓ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕࡢ୍⑕౛㸬ṑ⛉་⒪2008㸹22㸸120-127㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
 2015ᖺ1᭶⌧ᅾ㸪⩏ṑࡢ46ேᕤṑࡀ◚ᢡࡋ࡚ࡁࡓ
ࡓࡵ࡟ಟ⌮ࢆ⾜ࡗࡓ㸬ࡑࡢᙳ㡪࠿ࡣࡗࡁࡾࡋ࡞࠸
ࡀ43࢖ࣥࣉࣛࣥࢺ࿘ᅖࡢ㦵྾཰ࢆ㉳ࡇࡋ࡚ࡁࡓࡢ

− 165 −

第1日

日補綴会誌

第 3 会場

7･124 回特別号，2015

一般口演発表

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‫ۑ‬ᑠᒣ㞙ᖹ㸪▼ᶫᏕㅬ㸪௒஭ᝆ௓㸪௒஭Ᏺኵ

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*XP\R,PDL'HQWDO&OLQLFϨ㸬 ⥴ゝ ୗ㢡↓ṑ㢡ᝈ⪅࡟ᑐࡋᪧ⩏ṑࢆ฼⏝ࡋࡓ࣑ࢽ࢖
ࣥࣉࣛࣥࢺᨭྎ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕ(௨ୗ㸪MIOD)
἞⒪ࢆ⾜ࡗࡓࡀ」ᩘᅇࡢᨭྎ⬺㞳ࢆ⤒㦂ࡋࡓ㸬ࡑࡢཎᅉศᯒ⤖ᯝࢆ㋃ࡲ࠼2ᮏࡢHA࢖ࣥࣉࣛࣥࢺᨭ
ྎ࡬ࡢ⨨᥮࠾ࡼࡧ⩏ṑᗋᙧែ࡟㓄៖ࡋࡓ᪂⩏ṑࢆస〇ࡋⰋዲ࡞⤒㐣ࡀᚓࡽࢀࡓ⑕౛࡟ࡘ࠸࡚ⱝᖸࡢ
⪃ᐹࢆຍ࠼ሗ࿌ࡍࡿ㸬ϩ㸬 ⑕౛ࡢᴫせ ᝈ⪅㸹77ṓ⏨ᛶ㸬ึデ㸹2008ᖺ10᭶㸬୺ッ㸹ୗ㢡඲㒊ᗋ⩏ṑࡢ⥔ᣢ୙Ᏻᐃ࡟క࠺࿪ᄮᅔ㞴㸬Ϫ㸬 ⪃ᐹ࡜⤖ㄽ ᡤᐃࡢデᐹ࡜᳨ᰝࢆ⤒࡚㸪ᝈ⪅ࡢᪧ⩏ṑࢆ౑⏝ࡋࡓ࠸࡜ࡢᕼᮃࢆỮࡳ㸪ྠ⩏ṑࢆ౑⏝ࡍࡿ4ᮏᨭྎࡢMIOD἞⒪ࢆ⾜ࡗࡓ1㸪2)㸬ࡑࡢᚋࡢ⤒㐣ほᐹ୰㸪」ᩘᅇࡢᨭྎືᦂࡸ⬺㞳ࢆ⤒㦂ࡋࡓ㸬GoAᥥグἲ࡛ࡣỈᖹⓗ㢡఩࡟␗ᖖࡣㄆࡵ࡞࠿ࡗࡓ㸬ࡋ࠿ࡋᪧ⩏ṑᙧែデᰝ㸪⩏ṑᗋ㐺ྜヨ㦂࠾ࡼࡧ㌿そヨ㦂࡛ࡣⴭ᫂࡞ேᕤṑည⪖࡟క࠺ప఩ညྜ࠾ࡼࡧ୙㐺ษ࡞⩏ṑᗋ⦕ᙧែ㸪⊃࠸⯉ᡣࡀ㸪ືᦂ࣭⬺㞳ࢆច㉳ࡋ㸪୙Ᏻᐃ࡞⩏ṑ࡜࡞ࡗࡓ࡜⪃࠼ࡽࢀࡓ㸬ࡲࡓ࣑ࢽ࢖ࣥࣉࣛࣥࢺࡣ㧗ᚄ࡟ᑐࡋᖜᚄࡀᑠࡉ࠸ࡓࡵຊ
Ꮫⓗ㈇Ⲵ࡟ᙅࡃ㸪༶᫬ᇙධ࣭༶᫬㈇Ⲵࡀཎ๎࡛࠶
ࡿࡓࡵ࢜ࢵࢭ࢜࢖ࣥࢸࢢ࣮ࣞࢩࣙࣥࡢ⋓ᚓࡀ୙༑ศ࡛࠶ࡿࡇ࡜3)㸪᭦࡟ࡣ⏬ീᡤぢ࠿ࡽ㦵ᱱࡀ␯࡛࠶
ࡿࡇ࡜ࡀ␲ࢃࢀ㸪ࡇࢀࡽࡶືᦂ࣭⬺㞳ࡢᅉᏊ࡜ࡋ
࡚⪃࠼ࡽࢀࡓ㸬ᮏ⤖ᯝࢆ㋃ࡲ࠼㸪ṧᏑ࣑ࢽ࢖ࣥࣉ
ࣛࣥࢺࢆ㝖ཤࡋᕥྑ≟ṑ┦ᙜ㒊࡟Zimmer Dental
HA Spline Implant2ᮏࢆᇙධ㸪චⲴᮇ㛫ࢆ⤒࡚ࣟࢣ࣮ࢱ࣮࢔ࣂࢵࢺ࣓ࣥࢺࢆ⿦╔㸪ྠ᫬࡟᪂⩏ṑࢆస〇ࡋࡓ㸬᪂⩏ṑ⿦╔ᚋ5ᖺ⤒㐣ࡋ࢖ࣥࣉࣛࣥࢺࡸ⩏ṑ➼࡟᭷ព࡞␗ᖖࡣㄆࡵࡎ⤒㐣Ⰻዲ࡜ุ᩿ࡋࡓ㸬 HA࢖ࣥࣉࣛࣥࢺࡸࣟࢣ࣮ࢱ࣮࢔ࣂࢵࢺ࣓ࣥࢺࡢ
౑⏝ࡀዌຌࡋࡓࡇ࡜࡟ຍ࠼㸪㐺ษ࡞ညྜ㛵ಀࡸᗋᙧែࢆ᭷ࡍࡿ㸪⥔ᣢᏳᐃࢆ㔜どࡋࡓ⩏ṑ4)ࢆ᪂ࡓ࡟
స〇ࡍࡿࡇ࡜࡛ືᦂࡀᢚไ࡛ࡁࡓࡶࡢ࡜⪃࠼⩏ṑ
ᙧែࡀIOD἞⒪ࡢᡂྰ࡟኱ࡁࡃᙳ㡪ࡍࡿ࡜෌ㄆ㆑
ࡋࡓ㸬

ϫ㸬 ᩥ⊩
1) ᪥ᮏ⿵⥛ṑ⛉Ꮫ఍⦅㸬⿵⥛ṑ⛉デ⒪࢞࢖ࢻࣛ࢖ࣥ-ṑࡢḞᦆࡢ⿵⥛ṑ⛉デ⒪࢞࢖ࢻࣛ࢖ࣥ
20082) ᪥ᮏཱྀ⭍࢖ࣥࣉࣛࣥࢺᏛ఍⦅㸬ཱྀ⭍࢖ࣥࣉࣛࣥࢺ἞⒪ᣦ㔪20123) ኱᳃᱇஧ ࡯࠿㸬ୗ㢡࣑ࢽ࢖ࣥࣉࣛࣥࢺ࣮࢜
ࣂ࣮ࢹࣥࢳ࣮ࣕ࡜ୖ㢡㢡⩏ṑࢆ⿦╔ࡋࡓ↓ṑ㢡ࡢ1⑕౛㸬⚟ᒸṑ⛉኱ᏛᏛ఍㞧ㄅ2009;35;
115-121㸬4) ௒஭Ᏺኵ㸬ࣜࣥࢦ୸࠿ࡌࡾࢆྍ⬟࡟ࡍࡿ඲㒊ᗋ⩏ṑࡢ⮫ᗋ⾡ᘧ࡟ࡘ࠸࡚㸬Journal of biointegration2013;3;147-153㸬

− 166 −

日補綴会誌 7･124 回特別号，2015

第1日

第 3 会場

一般口演発表

1 ─ 3 ─ 36࢖ࣥࣉࣛࣥࢺ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕ࡟࠾ࡅࡿ⮻ṑ㒊ᨭྎ࢖ࣥࣉࣛࣥࢺ࡟㛵ࡍࡿ⮫ᗋⓗ⪃ᐹ







‫▼ۑ‬ᶫᏕㅬ㸪ᑠᒣ㞙ᖹ㸪௒஭ᝆ௓㸪௒஭Ᏺኵ

ࡄࡳࡻ࠺௒஭ṑ⛉་㝔

&OLQLFDO&RQVLGHUDWLRQVRIWKH/RDG([HUWHGIRUPRODUDUHDRQWKH,PSODQWVXSSRUWHG
2YHUGHQWXUH,VKLEDVKL7㸪.R\DPD6㸪,PDL<㸪,PDL0
*XP\R,PDL'HQWDO&OLQLFϨ㸬 ⥴ゝ ࢖ࣥࣉࣛࣥࢺ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕ(௨ୗ㸪IOD)ࡣ㸪ྛᏛ఍࢞࢖ࢻࣛ࢖ࣥ࡟ࡶᣦ㔪ࡀ♧ࡉࢀ㸪ୖ㢡ࡣ4ᮏ௨ୖ㸪ୗ㢡ࡣ2ᮏ௨ୖࡢᨭྎࡀዲࡲࡋ࠸࡜ࡉࢀࡿ1,2)㸬
ࡋ࠿ࡋ⥔ᣢᏳᐃࢆ⪃៖ࡋࡓ඲㒊ᗋ⩏ṑࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ᨭྎ࢖ࣥࣉࣛࣥࢺ࡬ࡢຍ㔜㈇ᢸ㍍ῶࡸ
ᨭྎᩘῶᑡࡀᮇᚅฟ᮶ࡿࡶࡢ࡜⪃࠼ࡿ㸬௒ᅇ㸪5ᖺ⤒㐣ࡋࡓୖୗ㢡ྛ4ᮏᨭྎࡢIOD⑕౛࡟ࡘ࠸࡚ⱝᖸࡢ▱ぢࢆᚓࡓࡓࡵሗ࿌ࡍࡿ㸬ϩ㸬 ⑕౛ࡢᴫせ ᝈ⪅㸹54ṓ⏨ᛶ㸬ึデ㸹2008ᖺ6᭶㸬୺ッ㸹㔜ᗘṑ࿘⅖࡟క࠺࿪ᄮᅔ㞴㸬Ϫ㸬 ⪃ᐹ࡜⤖ㄽ ᡤ ᐃ ࡢ デ ᐹ ࡜ ᳨ ᰝ ࢆ ⤒ ࡚ 2008 ᖺ 9 ᭶ ୗ 㢡 ࡟
Zimmer Dental HA Spline Implant4ᮏ㸪ྠᖺ11᭶ୖ㢡࡟ྠImplant4ᮏࢆᇙධࡋࡓ㸬⣙6ࣨ᭶ࡢචⲴᮇ㛫ࢆ⤒࡚2009ᖺ4᭶஧ḟᡭ⾡㸪ྠᖺ10᭶࡟ୖୗ㢡๓ṑ࣭኱⮻ṑ㒊࢖ࣥࣉࣛࣥࢺ࡟ࣟࢣ࣮ࢱ࣮࢔ࣂࢵࢺ࣓ࣥ
ࢺࢆ⿦╔ࡋ㸪ࡑࡢᚋ㸪⥔ᣢᏳᐃࢆ⪃៖ࡋࡓIODࢆస〇࣭⿦╔ࡋࡓ㸬⿦╔ᚋ┤ࡕ࡟⩏ṑ╔⬺ࡀᅔ㞴࡜ࡢッ࠼ࢆㄆࡵࡓ㸬GoAᥥグἲࡸ⩏ṑᗋ㐺ྜヨ㦂࣭㌿そヨ㦂ࡢ⤖ᯝ࡟᭷ព࡞ᡤぢࡣㄆࡵ࡞࠿ࡗࡓࡇ࡜
࠿ࡽ⥔ᣢຊࡀ㐣኱࡜ุ᩿ࡋ㸪኱⮻ṑ㒊࢖ࣥࣉࣛࣥ
ࢺ࡟ࡣ⩏ṑỿୗ㜵Ṇࡢࡳࢆ┠ⓗ࡜ࡋࡓ࢔ࣂࢵࢺ࣓
ࣥࢺ࡟⨨᥮ࡋࡓ㸬IOD⿦╔ᚋ5ᖺ⤒㐣ࡋཱྀ⭍ෆ㸪⩏ṑ㸪࢖ࣥࣉࣛࣥࢺ࡞࡝࡟᫂ࡽ࠿࡞␗ᖖࡣㄆࡵ࡚࠸࡞࠸㸬 5ᖺ⤒㐣᫬ࡢ᳨ドࢆ⾜ࡗࡓ࡜ࡇࢁ㸪GoAᥥグἲ࡛ࡣỈᖹⓗ㢡఩࡟᭷ព࡞ᡤぢࡣㄆࡵࡎ㸪㌿そヨ㦂࡟࠾࠸࡚ࡶ᫂ࡽ࠿࡞␗ᖖࡣㄆࡵ࡞࠿ࡗࡓ㸬ࡲࡓேᕤṑည⪖࡟క࠺⩏ṑືᦂ㔞ࡢቑຍࡣㄆࡵ࡞࠿ࡗࡓ㸬ࡋ࠿ࡋ⩏ṑᗋ㐺ྜヨ㦂࡛ࡣࠊୖ㢡ࡣ኱⮻ṑ㒊࢔ࣂࢵࢺ࣓ࣥࢺࡢ᭷↓࡟౫ࡽࡎ⿦╔᫬࡜ྠᵝࡢᡤぢࢆᚓࡓࡀ㸪ୗ㢡ࡣ኱⮻ṑ㒊࢔ࣂࢵࢺ࣓ࣥࢺᮍ⿦╔᫬࡟⮻ṑ㒊ᗋ⩏ṑࡢỿୗࡀㄆࡵࡽࢀࡓ㸬ᮏ⤖ᯝ࠿ࡽ㸪ୖ㢡ࡢᗋ⩏ṑỿୗ㜵Ṇࢆ┠ⓗ࡜ࡋࡓ኱⮻ṑ㒊࢖ࣥࣉࣛࣥࢺᨭྎࡢព⩏ࡣᑡ࡞࠸࡜⪃࠼ࡽࢀࡓ㸬௨ୖࡼࡾ㸪HA࢖ࣥࣉࣛࣥࢺࡢࣂ࢖࢜࢖ࣥࢸࢢ࣮ࣞࢩࣙ

ࣥࡢ⋓ᚓ㸪ࣟࢣ࣮ࢱ࣮࢔ࣂࢵࢺ࣓ࣥࢺ࡬ࡢຊᏛⓗ㓄៖㸪⥔ᣢᏳᐃࢆ⪃៖ࡋࡓ඲㒊ᗋ⩏ṑࡢ౑⏝3)㸪ࡢ᮲௳ࢆ‶ࡓࡍࡇ࡜࡛ୖ㢡2ᮏࡢᨭྎ࡟ࡼࡿIOD἞⒪ࢆ⾜࠸࠺ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡿ࡜࡜ࡶ࡟㸪ୗ㢡኱⮻ṑ㒊ᨭྎ࢖ࣥࣉࣛࣥࢺࡢ㔜せᛶࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) ᪥ᮏ⿵⥛ṑ⛉Ꮫ఍⦅㸬 ⿵⥛ṑ⛉デ⒪࢞࢖ࢻࣛ࢖ࣥ-ṑࡢḞᦆࡢ⿵⥛ṑ⛉デ⒪࢞࢖ࢻࣛ࢖
ࣥ 20082) ᪥ᮏཱྀ⭍࢖ࣥࣉࣛࣥࢺᏛ఍⦅㸬ཱྀ⭍࢖ࣥࣉࣛࣥࢺ἞⒪ᣦ㔪20123) ௒஭Ᏺኵ㸬ୖ㢡඲㒊ᗋ⩏ṑࡢືᦂ࡟㛵ࡍࡿ◊✲ : ➨2ሗ ᶵ⬟᫬ࡢ⩏ṑࡢືᦂ࡜㛵㐃ࡍࡿᅉᏊࡢศᯒ㸬᪥ᮏ⿵⥛ṑ⛉Ꮫ఍㞯ㄅ
1988;32;936-946㸬

− 167 −

第2日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表2─3─1

ᚑ᮶ἲ࠾ࡼࡧගᏛ༳㇟᫬ࡢCo-Cr࠾ࡼࡧZirconia FDPsࡢ㐺ྜ࡟ࡘ࠸࡚
‫୍⏣ୖۑ‬ᙪ  㸪Beuer F 㸪Stimmelmayr M 㸪Erdelt K 㸪Keul C ,Güth J 㸪Ώ㑓ᩥᙪ*᪥ᮏṑ⛉኱Ꮫ᪂₲⑓㝔⥲ྜデ⒪⛉㸪 **Dental School of the Ludwig- Maximilian University of Munich㸪***᪥ᮏṑ⛉኱Ꮫ᪂₲⏕࿨ṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨2ㅮᗙ
Fit of 4-unit FDPs from Co-Cr and Zirconia after conventional and digital impression
Ueda K*,**㸪Beuer F**, Stimmelmayr M**, Erdelt K**, Keul C**, Güth J**, Watanabe F***
*Comprehensive Dental Care, The Nippon Dental University Niigata Hospital,**Dental School of the Ludwig- Maximilian University of Munich,***Department of Crown & Bridge Prosthodontics, The Nippon Dental University Life Dentistry at NiigataϨ㸬 ┠ⓗ ㏆ᖺ㸪ᚑ᮶ࡢ༳㇟ἲࡢḞⅬࢆඞ᭹ࡍࡿࡓࡵ࡟㸪ගᏛ༳㇟᥇ᚓࡀ⾜ࢃࢀࡿࡼ࠺࡟࡞ࡗ࡚࠸ࡿ㸬ᮏ◊✲࡛ࡣ㸪ᚑ᮶ࡢ༳㇟ἲ࡜ගᏛ༳㇟ἲ࡟ࡼࡾ
CAD/CAM࡛〇㐀ࡉࢀࡓ4ࣘࢽࢵࢺ Co-Cr࠾ࡼࡧ
Zirconiaࡢᅛᐃᛶ⿵⥛⿦⨨ࡢ࣐࣮ࢪࣥ㒊࡜ෆ㒊ࡢ㐺ྜࢆ᳨ウࡋࡓ㸬ϩ㸬 ᪉ἲ 2ṑ㐃⥆Ḟᦆࡢ4ࣘࢽࢵࢺᅛᐃᛶ⿵⥛⿦⨨ (FDP)ࢆ〇సࡍࡿࡓࡵ࡟14࡜17ࢆᨭྎṑ࡜ࡋࡓࢳࢱࣥ〇࣐ࢫࢱ࣮ࣔࢹࣝࢆ⏝࠸ࡓ㸬࣐ࢫࢱ࣮ࣔࢹࣝࢆࢩࣜ
ࢥ࣮ࣥ༳㇟᥇ᚓࡋ㸪ᚑ᮶ἲ࡛⾜ࡗࡓ⩌㸦CI, n=12㸧ࡣసᴗ⏝ᶍᆺ〇సᚋ㸪ᢏᕤ⏝ࢫ࢟ࣕࢼ࣮ࢆ⏝࠸࡚ࢹࢪࢱࣝࢹ࣮ࢱࢆྲྀᚓࡋ㸪ගᏛ༳㇟ἲ࡟ࡼࡾ༳㇟
᥇ᚓࢆ⾜ࡗࡓ⩌ (DI, n=12) ࡣ࣐ࢫࢱ࣮ࣔࢹࣝࢆ࢜
࣮ࣛࣝࢫ࢟ࣕࢼ࣮࡟࡚㸪ගᏛ༳㇟᥇ᚓࢆ⾜࠸㸪ࢹࢪࢱࣝࢹ࣮ࢱࢆྲྀᚓࡋࡓ㸬ࡉࡽ࡟㸪CI, DI⩌ඹ࡟ྛ༳㇟᥇ᚓ࡛ᚓࡓࡑࢀࡒࢀࡢࢹ࣮ࢱࢆ⏝࠸࡚
Zirconia (Z) ࡜Co-Cr (C) ࡢFDPsࢆྛ⩌࡜ࡶ࡟ྠࢹ
࣮ࢱ࡟࡚12ಶ㸪ィ48ಶ〇సࡋࡓ㸬㐺ྜࡢ ᐃ࡟ࡣࣞࣉࣜ࢝ࢸࢡࢽࢵࢡ1,2)ࢆ㐺⏝ࡋ㸪ࣞࣉࣜ࢝ࡣFDP
ࡈ࡜࡟㏆㐲ᚰ㸪㢋⯉᪉ྥࡢ2ಶసᡂࡋ㸪1ṑ࡟ᑐࡋ࡚ࡑࢀࡒࢀ㏆㐲ᚰ㸪㢋⯉㒊ࡢ4㒊఩ࡢ㸪࣐࣮ࢪࣥ㒊(MO), ࢳࣕࣥࣇ࢓࣮㒊 (CA), ㍈㠃㒊 (AW), ညྜ㠃㒊 (OC)㸦ᅗ㸧ࡢ㐺ྜࢆ ᐃࡋ㸪ྜィ1536㒊఩࡟ࡘ࠸࡚⾜ࡗࡓ㸬⤫ィᏛⓗศᯒࡣ㸪Mann-Whiteny
U-test (P < 0.05) ࢆ⏝࠸ࡓ㸬

4. DI⩌
 DI-C⩌ࡣDI-Z⩌࡜ẚ㍑ࡋ࡚MO, CA, AW㒊࡟࠾࠸࡚᭷ព࡟ప࠸್ࢆ♧ࡋࡓ㸬ࡋ࠿ࡋ㸪OC㒊࡟ࡘ࠸࡚⤫ィᏛⓗ᭷ពᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬 ඲࡚ࡢࢢ࣮ࣝࣉ࡟࠾࠸࡚࣐࣮ࢪࣥ㒊ࡢ㐺ྜࡣ㸪⮫ᗋⓗ࡟‶㊊ࡢ࠸ࡃ⤖ᯝࢆ♧ࡋࡓ㸬ࡇࢀࡣᚑ᮶ࡢ
༳㇟᥇ᚓࡤ࠿ࡾ࡛࡞ࡃ㸪ࢹࢪࢱࣝ༳㇟᥇ᚓࡶ⮫ᗋୖ㸪᭷⏝࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ࡜⪃࠼ࡿ㸬ࡲࡓ㸪
DI⩌࡟࠾࠸࡚DI-Z⩌࡜ẚ㍑ࡋ࡚DI-C⩌ࡢ᪉ࡀ㸪᭷ព࡟ప࠸್ࢆ♧ࡋࡓ㸬ࡇࢀࡣZirconiaࡢ↝⤖⾜⛬᫬ࡢ↝⤖཰⦰ࡢᙳ㡪࡛࠶ࡿ࡜⪃࠼ࡿ㸬 ௒ᅇࡢ◊✲࡛ࡣ␗࡞ࡿ࣮࣡ࢡࣇ࣮ࣟ㸪౑⏝ᮦᩱࡢẚ㍑ࡀྍ⬟࡛࠶ࡗࡓࡀ㸪ཱྀ⭍ෆ࡛ࡢ≧ែࢆ᏶඲࡟෌⌧ࡋ࡚࠸࡞࠸㸬ᚑࡗ࡚㸪ࡉࡽ࡞ࡿin vivo࡛ࡢᐇ㦂ࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡿ㸬
ϫ㸬ᩥ⊩
1.

Molin M, Karlsson S. (1993) The fit of gold
inlays and three ceramic inlay systems. A
clinical in vitro study. Acta Odontol Scand
51:201-6.

2.

Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1. Co-Cr FDPs DI-C⩌ࡣCI-C⩌࡜ẚ㍑ࡋ࡚඲࡚ࡢ㒊఩࡟࠾࠸࡚
᭷ព࡟ప࠸್ࢆ♧ࡋࡓ㸬
2. Zirconia FDPs DI-Z⩌ࡣCI-Z⩌࡜ẚ㍑ࡋ࡚CA, AW㒊఩࡟࠾࠸࡚᭷ព࡟ప࠸್ࢆ♧ࡋࡓ㸬ࡋ࠿ࡋ㸪MO, OC㒊࡟ࡘ࠸࡚⤫ィᏛⓗ᭷ពᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ.
3. CI⩌
 CI-C⩌࡜CI-Z⩌࡟࠾࠸࡚඲࡚ࡢ㒊఩࡛ࡣ⤫ィᏛⓗ᭷ពᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬− 168 −

Boening KW, Wolf BH, Schmidt AE, Kästner K,
Walter MH. (2000) Clinical fit of Procera all-ceram
crowns. J Prosthet Dent 84:419-24.

ィ㒊఩

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2─3─2

㸯ᾮᛶ࣎ࣥࢹ࢕ࣥࢢᮦ୰࡟ྵࡲࢀࡿࢩࣛࣥ࢝ࢵࣉࣜࣥࢢᮦࡢ
࢝ࢵࣉࣜࣥࢢຠᯝࡢ᳨ウ‫ྜྷۑ‬ཎஂ⨾Ꮚ㸪㛗ᒸ⣖ᖾ*㸪ධỤṇ㑻**㸪すᕝᝅ㑻***㸪୸ᑿᖾ᠇***㸪ᯇᮏ༟ஓ**㸪
ⓙᮌ┬࿃****, ྜྷ⏣㟹ᘯ*****

ᒸᒣ኱Ꮫ⑓㝔᪂་⒪㛤Ⓨࢭࣥࢱ࣮㸪*ᒸᒣ኱ᏛṑᏛ㒊ඛ➃㡿ᇦ◊✲ࢭࣥࢱ࣮㸪**ᒸᒣ኱Ꮫ་
ṑ⸆Ꮫ⥲ྜ◊✲⛉⏕యᮦᩱᏛศ㔝㸪***ᒸᒣ኱Ꮫ⑓㝔ညྜ࣭⩏ṑ⿵⥛⛉㸪****ᒸᒣ኱Ꮫ་ṑ⸆Ꮫ⥲ྜ◊✲⛉ညྜ࣭᭷ᗋ⩏ṑ⿵⥛Ꮫศ㔝㸪*****໭ᾏ㐨኱ᏛṑᏛ◊✲⛉⏕యᮦᩱᕤᏛศ㔝A Study for the effect of silane coupling in one bottle dental adhesives
Yoshihara K, Nagaoka N*, Irie M**, Nishigawa G***, Maruo Y***, Matsumoto T**, Minagi S****, Yoshida
Y*****.
Center for Innovative Clinical Medicine, Okayama University Hospital, *Advanced Research Center for Oraland Craniofacial Sciences, Okayama University, **Department of Biomaterials, Okayama University,***Occlusion & Remobable Prosthodontics, Okayama University Hospital, ****Deptartment of Occlusal &Oral Funcctional Rehabilitation, Okayama University, ***** Department of Biomaterials, Hokkaido

Ϩ. ┠ⓗ ㏆ᖺ㸪ᵝࠎ࡞ᡂศࢆ1ᮏ࡟ῧຍࡋ㸪ࢭ࣑ࣛࢡࢫ㸪㔠ᒓ࡞࡝ከ✀ࡢ⿕╔య࡟᥋╔ࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿ
ࣘࢽࣂ࣮ࢧࣝࢱ࢖ࣉࡢ᥋╔ᮦᩱࡀከᩘⓎ኎ࡉࢀ࡚࠸ࡿ㸬ࣘࢽࣂ࣮ࢧࣝࢱ࢖ࣉ࡟ῧຍࡉࢀ࡚࠸ࡿࢩࣛ
ࣥ࢝ࢵࣉࣜࣥࢢ๣ࡣ㸪ỈࡢᏑᅾ᮲௳ୗ࡛ࡣᏳᐃ࡞
≧ែ࡛Ꮡᅾࡍࡿࡇ࡜ࡀᅔ㞴࡛࠶ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠸ࡿࡀ㸪ࣘࢽࣂ࣮ࢧࣝࢱ࢖ࣉࡢ᥋╔๣୰ࡢࢩࣛࣥ
࢝ࢵࣉࣜࣥࢢ๣ࡀᐇ㝿࡟ຠᯝࢆⓎ᥹ࡋ࡚࠸ࡿ࠿ࢆ
ヲ⣽࡟᳨ウࡋࡓࡶࡢࡣᑡ࡞࠸㸬ࡑࡇ࡛㸪௒ᅇࣘࢽࣂ࣮ࢧࣝࢱ࢖ࣉ᥋╔๣࡟ྵࡲࢀࡿࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡢ᭷ຠᛶ࡟ࡘ࠸᳨࡚ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ. ᪉ἲ ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡢ᭷ຠᛶホ౯ࡣ㸪ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡀ࢞ࣛࢫ࡜໬Ꮫⓗ⤖ྜࡋ࡚࠸ࡿ࠿
ࢆ᥋╔ヨ㦂࡛ホ౯ࡋ㸪ࡉࡽ࡟᥋╔ᡂศࡢFTIRศᯒ࡟ࡼࡾホ౯ࢆ⾜ࡗࡓ㸬ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡢ᥋╔ヨ㦂࡛ࡣ㸪໬Ꮫⓗ᥋╔ࡢࡳࢆホ౯ࡍࡿࡓࡵࠊ10103 mmࡢ㙾㠃▼ⱥ࢞ࣛࢫࢆ⏝࠸ࡓ㸬▼ⱥ࢞ࣛࢫ⾲㠃ࢆK-࢚ࢵࢳࣕࣥࢺࢤࣝ㸦ࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧࡛Ὑίࡋ㸪ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡀྵ᭷ࡉࢀ࡚࠸ࡿࢫࢥࢵࢳ
࣎ࣥࢻࣘࢽࣂ࣮ࢧࣝ㸦3M ESPE㸧㸪ẚ㍑࡜ࡋ࡚ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ᮍྵ᭷ࢡࣜ࢔ࣇ࢕ࣝࢺࣛ࢖࢚
ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡ㸦ࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧㸪ࡉࡽ࡟࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋ࢱ࣮㸦ࢡࣛࣞࣀࣜࢱ
ࢣࢹࣥࢱࣝ㸧࡜ࢡࣜ࢔ࣇ࢕ࣝࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡࡢΰྜ⁐ᾮࢆሬᕸࡋ㸪ࡑࢀࡒࢀ࢚࢔࣮஝
⇱ᚋ㸪ග↷ᑕࢆ⾜ࡗࡓ㸬ࢡࣜ࢔ࣇ࢕ࣝࢭ࣑ࣛࢵࢡ
ࣉࣛ࢖࣐࣮㸦ࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧࡛ฎ⌮ࡋࡓࢪࣝࢥࢽ࢔ࡢࡏࢇ᩿Წࢆ㸪ࢡࣜ࢔ࣇ࢕࢚ࣝࢫࢸ
ࢸ࢕ࢵࢡࢭ࣓ࣥࢺ㸦ࢡࣛࣞࣀࣜࢱࢣࢹࣥࢱࣝ㸧࡛ྜ╔ࡋ㸬෌ᗘග↷ᑕࢆ⾜ࡗࡓ㸬స〇ࡋࡓࢧࣥࣉࣝ
ࡣ㸪1᪥㛫37 Υ⵨␃Ỉ୰ᾐₕᚋࡏࢇ᩿᥋╔ᙉࡉࢆࢡ ࣟ ࢫ ࣊ ࢵ ࢻ ࢫ ࣆ ࣮ ࢻ 0.5 mm/min ࡛ ᐃ ࡋ ࡓ(N=10)㸬ᚓࡽࢀࡓࢹ࣮ࢱࡣ㸪One-way ANOVA㸪Tukeyἲࢆ⏝࠸࡚⤫ィゎᯒࢆ⾜ࡗࡓ㸦Ș㸺0.05㸧.
 FTIRศᯒࡣ㸪KBrࣉ࣮ࣞࢺ㸦ࢪࣕࢫࢥ࢚ࣥࢪࢽ
࢔ࣜࣥࢢ㸧ࡢୖ࡟㸪ࡏࢇ᩿ヨ㦂࡜ྠᵝࡢࢧࣥࣉࣝ㸪ࢫࢥࢵࢳ࣎ࣥࢻࣘࢽࣂ࣮ࢧࣝ㸪ࢺࣛ࢖࢚ࢫ࣎ࣥࢻ
NDࢡ࢖ࢵࢡ㸪࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋ࢱ࣮࡜ࢺࣛ࢖
࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡΰྜ⁐ᾮ࡟ຍ࠼ẚ㍑࡜ࡋ࡚
࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋ࢱ࣮ࢆࡑࢀࡒࢀሬᕸࡋ㸪࢚࢔࣮஝⇱ᚋ㸪FTIR㸦IRAffinity-1S㸪ᓥὠ〇సᡤ㸧ࢆ⏝࠸࡚㏱㐣ἲ࡛ ᐃࢆ⾜ࡗࡓ㸬Ϫ. ⤖ᯝ࡜⪃ᐹ ࡏࢇ᩿᥋╔ᙉࡉ㸦MeansSD MPa㸧ࡣ㸪ࢫࢥࢵࢳ࣎ࣥࢻࣘࢽࣂ࣮ࢧ࡛ࣝࡣ9.39s3.4 MPa㸪ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡ࡛ࡣ9.85s5.1 MPa㸪࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋ࢱ࣮࡜ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡࡢΰ࿴࡛ࡣ27.32s6.0 MPa࡛࠶ࡾ㸪࣏࣮ࢭࣞࣥ࢔
ࢡࢳ࣮࣋ࢱ࣮࡜ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡࡢΰ
࿴ࡀ᭷ព࡟㧗࠿ࡗࡓ㸬᥋╔ᙉࡉᚋࡢ◚᩿㠃ࡣ㸪ࢫࢥࢵࢳ࣎ࣥࢻࣘࢽࣂ
࣮ࢧࣝ࡜ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡ࡛ࡣࡍ࡭࡚
⏺㠃◚ቯ࡛࠶ࡗࡓ㸬୍᪉㸪࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋
ࢱ࣮࡜ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡࡢΰ࿴࡛ࡣࡍ
࡭࡚ࡢヨᩱ࡛࢞ࣛࢫෆ࡛ࡢจ㞟◚ቯࢆ♧ࡋࡓ㸬
FTIR࡛ࡣ㸪࣏࣮ࢭࣞࣥ࢔ࢡࢳ࣮࣋ࢱ࣮࡛ࡣ㸪ࢺࣛ࢖࢚ࢫ࣎ࣥࢻNDࢡ࢖ࢵࢡࡢῧຍ࡟ࡼࡾ㸪ࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡀຍỈศゎ཯ᛂࡋ࡚࠸ࡿࡇ࡜ࡀࡣ
ࡗࡁࡾ࡜☜ㄆ࡛ࡁࡓࡀ㸪ࢫࢥࢵࢳ࣎ࣥࢻࣘࢽࣂ࣮
ࢧ࡛ࣝࡣࢩࣛࣥ࢝ࢵࣉࣜࣥࢢ๣ࡢຍỈศゎ཯ᛂ࡟⏤᮶ࡍࡿࣆ࣮ࢡࡀ☜ㄆ࡛ࡁ࡞࠿ࡗࡓ1).
ࡇࡢࡼ࠺࡟㸪ࡏࢇ᩿᥋╔ᙉࡉヨ㦂㸪FTIRศᯒ࠿ࡽ㸯ᾮᛶࡢ࣎ࣥࢹ࢕ࣥࢢᮦ୰࡟ྵࡲࢀࡿࢩࣛࣥ࢝
ࢵࣉࣜࣥࢢࡣ඘ศ࡞᭷ຠᛶࡀᚓࡽࢀ࡞࠸ࡇ࡜ࡀࢃ
࠿ࡗࡓ㸬ࡇࢀࡣῧຍࡉࢀ࡚࠸ࡿࢩࣛࣥ࢝ࢵࣉࣜࣥ
ࢢ๣ࡀᑡ㔞࡛࠶ࡿࡇ࡜࡜㸪࣎ࣥࢹ࢕ࣥࢢᮦ୰ࡢỈ㸪㓟ᛶࣔࣀ࣐࣮ࡢ࡞࡝ࡢᙳ㡪࡛Ᏻᐃ࡟Ꮡᅾ࡛ࡁࡎ࢜
ࣜࢦ࣐࣮໬ࡋ࡚࠸ࡿࡓࡵ࡜⪃࠼ࡽࢀࡿ㸬ϫᩥ⊩
1) Matinlinna JP et al. Dent Mater 2004;20:804-813− 169 −

第2日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表2─3─3

ྛ✀CAD/CAM⏝ࣁ࢖ࣈࣜࢵࢻࣞࢪࣥ࡜᥋╔ᛶࣞࢪࣥࢭ
࣓ࣥࢺࡢ᥋╔ᙉࡉ࡟㛵ࡍࡿ◊✲‫ۑ‬᪂ಖ⚽ோ㸪▼ᕝ┤ᶞ㸪⬥ᣅஓ㸪௰⏣㇏⏕㸪Ḉ஭ᩄ⥅㸪⨶ᗈ↡㸪㕥ᮌᜤ඾㸪኱ஂಖຊᘅ㭯ぢ኱ᏛṑᏛ㒊᭷ᗋ⩏ṑ⿵⥛Ꮫㅮᗙ
Bonding strengths of hybrid resin for CAD/CAM crown to resin cements
Shimpo H, Ishikawa N, Waki T, Nakata T, Sakurai T, Ra K, Suzuki Y, Ohkubo C
Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine㸪Ϩ㸬 ┠ⓗ 2014 ᖺ 4 ᭶࡟ṑ⛉デ⒪ሗ㓘ᨵᐃ࡟ࡼࡾ㸪CAD/CAM ࢩࢫࢸ࣒ࢆ฼⏝ࡋ࡚〇సࡉࢀࡓࣁ࢖ࣈࣜࢵࢻࣞࢪࣥࢡࣛ࢘ࣥ
ࡀᑟධࡉࢀࡓ㸬㧗ᐦᗘ࡟ᅽ⦰ࡉࢀࡓࣇ࢕࣮ࣛࢆྵࡴࣞࢪࣥ
ࣈࣟࢵࢡࢆ౑⏝ࡍࡿࡇ࡜࡟ࡼࡾ㸪㧗ᙉᗘ࡜ඃࢀࡓ◊☻ᛶࢆ୧❧ࡋ࡚࠸ࡿ㸬⌧ᅾ㸪⮫ᗋᛂ⏝ࡉࢀ࡚࠿ࡽ⣙༙ᖺࡀ⤒㐣ࡋ㸪࠸ࡃࡘ࠿ࡢၥ㢟Ⅼࡶᣲࡆࡽࢀ࡚࠸ࡿ㸬࡞࠿࡛ࡶࣁ࢖ࣈࣜࢵ
ࢻࣞࢪࣥࢡࣛ࢘ࣥࡢ⬺㞳ࡀሗ࿌ࡉࢀ࡚࠾ࡾ㸪ࣞࢪࣥࣈࣟࢵ
ࢡ࡜ࡢ᥋╔ᛶࢆゎ᫂ࡍࡿࡇ࡜ࡣᛴົ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿ 1)㸬
ࡑࡇ࡛ᮏ◊✲ࡣྛ✀ࣁ࢖ࣈࣜࢵࢻࣞࢪࣥ࡜⌧ᅾ౑⏝ࡉࢀ࡚࠸ࡿ᥋╔ᛶࣞࢪࣥࢭ࣓ࣥࢺࡢ᥋╔ᛶ࡟㛵ࡋ࡚ᐇ㦂ⓗ᳨ウࢆ⾜ࡗࡓ㸬

㸦15.8 Mpa㸧ࡀࣞࢪࢭ࣒㸦6.2 MPa㸧㸪SA࣮ࣝࢸ࢕ࣥࢢ
ࣉࣛࢫ㸦7.3 Mpa㸧࡜ẚ㍑ࡋ࡚᭷ព࡟㧗࠸᥋╔ᙉࡉࢆ♧ࡋࡓ()㸬ࡲࡓ㸪ࣦࣛ࢓࢔ࣝࢸ࢕࣓ࢵࢺ࠾ࡼࡧࢭࣛࢫ
࣐࣮ࢺ࡟࠾࠸࡚ࡶྠᵝࡢഴྥࢆ♧ࡋࡓ㸬KZR-CAD࡛ࡣࢫ࣮ࣃ࣮࣎ࣥࢻ㸦16.6 Mpa㸧ࡀ௚ࡢ᥋╔ᛶࣞࢪࣥࢭ࣓ࣥ
ࢺ࡜ẚ㍑ࡋ࡚᭷ព࡟㧗࠸᥋╔ᙉࡉࢆ♧ࡋࡓ㸬◚ቯᵝ┦ࡢほᐹ࡛ࡣ㸪ࣜࣛ࢖࢚ࢵࢡࢫ࢔ࣝࢸ࢕࣓ࢵࢺࡀKZR-CAD
௨እ࡛ࣞࢪࣥࣈࣟࢵࢡෆ࡛ࡢจ㞟◚ቯࢆㄆࡵࡓ㸬୍᪉㸪ࢫ࣮ࣃ࣮࣎ࣥࢻ࡛ࡣ඲࡚ࡢࣞࢪࣥࣈࣟࢵࢡ࡛ࢭ࣓ࣥࢺෆ
࡛ࡢจ㞟◚ቯࢆㄆࡵࡓ㸬ࣜࣛ࢖࢚ࢵࢡࢫ࢔ࣝࢸ࢕࣓ࢵࢺ
࠾ࡼࡧࢫ࣮ࣃ࣮࣎ࣥࢻࡣ㸪⌧ᅾ౑⏝ࡉࢀ࡚࠸ࡿ
CAD/CAMෙ⏝ࣞࢪࣥࣈࣟࢵࢡ࡟ᑐࡋ࡚㧗࠸᥋╔ຊࢆ᭷ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϩ㸬 ᪉ἲࣁ࢖ࣈࣜࢵࢻࣞࢪࣥࣈࣟࢵࢡࡣ⌧ᅾಖ㝤ᑟධࡉࢀ࡚࠸ࡿ
୰ࡢ 4 ✀㢮㸦ࢭࣛࢫ࣐࣮ࢺ㸸GC㸪ᯇ㢼ࣈࣟࢵࢡ HC㸸ᯇ㢼㸪KZR-CAD㸸ᒣᮏ㈗㔠ᒓ㸪ࣦࣛ࢓࢔ࣝࢸ࢕࣓ࢵࢺ㸸3M㸧
ࢆ㑅ᢥࡋࡓ㸬᥋╔ᛶࣞࢪࣥࢭ࣓ࣥࢺࡣࢫ࣮ࣃ࣮࣎ࣥࢻ㸦ࢧ࣓ࣥࢹ࢕࢝ࣝ㸧㸪ࢪ࣮ࢭ࣒ࢭࣛࢫ࣐࣮ࢺ㸦GC㸧
㸪ࣜࣛ࢖࢚ࢵࢡࢫ࢔ࣝࢸ࢕࣓ࢵࢺ㸦3M㸧
㸪SA ࣮ࣝࢸ࢕ࣥࢢࣉࣛࢫ
㸦ࢡࣛࣞࣀࣜࢱࢣ㸧ࡢ 4 ✀㢮ࢆ㑅ᢥࡋࡓ㸬ࣉ࣮ࣞࢺ≧㸦10.0×10.0×2.0 mm㸧࡟ᡂᙧࡋࡓࣁ࢖ࣈࣜࢵࢻࣞࢪࣥࣈࣟ
ࢵࢡࢆ#600 ࡢ࢚࣓࣮ࣜ⣬࡟࡚◊☻㸪࢔࣑ࣝࢼࢧࣥࢻࣈࣛ
ࢫࢺฎ⌮ᚋ㸪⿕╔㠃ࢆࢸ࣮ࣉ࡟࡚┤ᚄ 4.8 mm ࡟つᐃࡋࡓ㸬ࡑࡢᚋ㸪ᘬᙇヨ㦂⏝ヨᩱ࡜ࡋ࡚ᡂᙧࡍࡿࡓࡵ࡟㸪⿕╔㠃࡟ࣁ࢖ࣈࣜࢵࢻࣞࢪࣥ࡜᥋╔ᛶࣞࢪࣥࢭ࣓ࣥࢺࡢ᥋
᥋╔ᛶࣞࢪࣥࢭ࣓ࣥࢺࢆሬᕸࡋୖ࡟࢔ࢡࣜࣝᲬࢆ௜୚ࡋࡓ㸬╔ᙉࡉ㸦ᯇ㢼ࣈࣟࢵࢡ HC㸧ࣞࢪࣥࢭ࣓ࣥࢺ㔜ྜᚋ㸪37Υࡢ⵨␃Ỉ୰࡟ 24 ᫬㛫ᾐₕࡋ㸪ヨᩱ࡜ࡋࡓ㸬ィ ࡣ AUTOGRAPH㸦AG-IS㸪ᓥὠ〇సᡤ㸧ϫ㸬 ᩥ⊩ࢆ౑⏝ࡋ࡚ࢡࣟࢫ࣊ࢵࢻࢫࣆ࣮ࢻ 2.0 mm/min.࡟࡚ᘬᙇヨ1) ␭⏣ ୍ὒ㸪⯙⏣ ೺ኵ, ᕝୖ ᬛྐ࡯࠿㸬㦂ࢆ⾜ࡗࡓ㸬ᚓࡽࢀࡓࢹ࣮ࢱࡣ୍ඖ㓄⨨ศᩓศᯒᚋ㸪
CAD/CAM⏝ࣁ࢖ࣈࣜࢵࢻࣞࢪࣥࣈࣟࢵࢡ࡟ᑐࡍ
Tukey ࡢከ㔜ẚ㍑ࢆ⾜࠸༴㝤⋡ 5%᳨࡛ᐃࢆ⾜ࡗࡓ㸬ᘬᙇࡿ᥋╔ᛶࣞࢪࣥࢭ࣓ࣥࢺࡢ᥋╔ຠᯝ㸬᥋╔ṑᏛࡾヨ㦂ᚋ㸪ࣞࢪࣥࣈࣟࢵࢡ⾲㠃ࢆගᏛ㢧ᚤ㙾㸦×10㸧
2008; 26(2), 124-128.
࡟࡚ほᐹࡋ㸪⏺㠃ࡢ㟢ฟࡀ 80%௨ୖࡢሙྜࡣ⏺㠃◚ቯ㸪ࣞࢪࣥࢭ࣓ࣥࢺࡢ௜╔ࡀ 80%௨ୖㄆࡵࡽࢀࡓሙ
ྜࡣจ㞟◚ቯ㸪ࡑࡢ௚ࢆΰྜ◚ቯ࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᅗ࡟♧ࡍࡼ࠺࡟㸪ᯇ㢼ࣈࣟࢵࢡHC࡟࠾࠸࡚ࡣࢫ࣮ࣃ
࣮࣎ࣥࢻ㸦19.2 MPa㸧࡜ࣜࣛ࢖࢚ࢵࢡࢫ࢔ࣝࢸ࢕࣓ࢵࢺ

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日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2─3─4

SS-OCTࢆ⏝࠸ࡓୖ㢡๓ṑ㒊ࡢ㠀౵くⓗ࢚ࢼ࣓ࣝ㉁ཌᚄࡢ ᐃ‫ۑ‬ᐑᇛගᚿ㸪᱓㭯฼㤶㸪⠏ᒣ⬟኱㸪ྂ㇂㔝₩஑ᕞ኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲㝔ཱྀ⭍ᶵ⬟ಟ᚟Ꮫㅮᗙ࢖ࣥࣉࣛࣥࢺ࣭⩏ṑ⿵⥛Ꮫศ㔝
A Noninvasive Measurement of The Enamel Thickness of Maxillary Anterior Teeth with Swept Source
Optical Coherence Tomography
Miyagi H, Kuwatsuru R, Tsukiyama Y, Koyano K
Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science,
Kyushu UniversityϨ㸬 ┠ⓗ࣑ࣛࢿ࣮ࢺ࣋ࢽ࢔ࡢᨭྎṑᙧᡂ࡛ࡣ㸪࢚ࢼ࣓ࣝ㉁ෆ࡟ᙧᡂࢆ␃ࡵࡿࡇ࡜ࡀ᥎ዡࡉࢀ࡚࠾ࡾ㸪⾡๓࡟࢚ࢼ࣓ࣝ㉁ཌᚄࢆᢕᥱࡍࡿࡇ࡜ࡀ㔜せ࡛࠶ࡿ㸬ࡋ࠿ࡋ㸪⮫ᗋṑෙࡢ࢚ࢼ࣓ࣝ㉁ཌᚄ࡟㛵ࡍࡿሗ࿌ࡣ㠀ᖖ࡟ᑡ࡞࠸㸬୍᪉㸪㏆㉥እග࡟ࡼࡾ㠀౵くⓗ࡟ ⤌ ⧊ ࡢ ᩿ ᒙ ⏬ ീ ࢆ ᚓ ࡽ ࢀ ࡿ optical coherence
tomography (OCT)ࡣ㸪⏬ീୖࡢཌࡳࢆࡑࢀࡒࢀࡢ
⤌⧊ࡢᒅᢡ⋡࡛㝖ࡍࡿࡇ࡜࡛ࡑࡢ⤌⧊ࡢཌࡳࡀᐇ
ྍ⬟࡛࠶ࡿ㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪OCT࡟ࡼࡿ࢚ࢼ࣓
ࣝ㉁ཌᚄࡢ ᐃ⢭ᗘࢆ᳨ドࡋࡓሗ࿌ࡣ࡞࠸㸬ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪Swept Source-OCT (SS-OCT)⿦⨨ࡢ
࢚ࢼ࣓ࣝ㉁ཌᚄࡢ ᐃ⢭ᗘࢆ㸪ᢤཤṑࢆ⏝࠸᳨࡚ウࡋ㸪ࡉࡽ࡟ୖ㢡๓ṑ㒊ࡢ⮫ᗋṑෙ࡟࠾ࡅࡿ࢚ࢼ
࣓ࣝ㉁ཌᚄࢆᖺ௦᳨ู࡛ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ OCTࢆ⏝࠸ࡓ࢚ࢼ࣓ࣝ㉁ཌᚄࡢ ᐃ⢭ᗘࡢ᳨ド࡟ࡣ㸪ୖ㢡୰ษṑ16ᮏ࡜ୖ㢡ഃษṑ10ᮏࡢ᪂㩭ᢤཤṑࢆ⿕㦂ṑ࡜ࡋࡓ㸬⿕㦂ṑࡢ1ṑ࠶ࡓࡾ28࠿ᡤࢆィ 㒊఩࡜ࡋ㸪SS-OCT⿦⨨ (ࣉࣟࢺ1㸪ࣃࢼࢯࢽࢵࢡ࣊ࣝࢫࢣ࢔♫〇)ࢆ⏝࠸㸪࢚ࢼ࣓ࣝ㉁ࡢᒅᢡ⋡ࢆ1.631)࡜ࡋ࡚ྛィ 㒊఩ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄࢆ⟬ฟࡋࡓ㸬ࡑࡢᚋ㸪ගᏛ㢧ᚤ㙾ࢆ⏝࠸࡚ྛ⿕㦂ṑࡢ࢚
ࢼ࣓ࣝ㉁ཌᚄࢆᐇ ࡋ㸪ྛィ 㒊఩ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄࡢ ᐃㄗᕪࢆ᳨ウࡋࡓ㸬ḟ࡟㸪SS-OCT⿦⨨ࢆ⏝࠸࡚⮫ᗋṑෙ࡛ࡢ࢚ࢼ࣓
ࣝ㉁ཌᚄࡢ ᐃࢆ⾜ࡗࡓ㸬⿕㦂⪅ࡣ㸪ᮏ◊✲࡬ࡢྠពࡀᚓࡽࢀࡓ஑ᕞ኱Ꮫ⫋ဨཬࡧᏛ⏕㸪஑ᕞ኱Ꮫ⑓㝔࡟᮶㝔ࡋࡓᝈ⪅࡛㸪ୖ㢡ᕥྑ࡝ࡕࡽ࠿ࡢ୰ษ
ṑ㸪ഃษṑ㸪≟ṑࡢ࠸ࡎࢀ࠿ࡢṑࢆ᭷ࡍࡿ20ṓ௨ୖࡢ⪅࡜ࡋࡓ㸬࢚ࢼ࣓ࣝ㉁ཌᚄࡢ ᐃ࡟ࡣSS-OCT⿦⨨ (ࣉࣟࢺ2㸪ࣃࢼࢯࢽࢵࢡ࣊ࣝࢫࢣ࢔♫〇)ࢆ౑⏝ࡋࡓ㸬ィ 㒊఩ࡣ㸪၁ഃṑ⫗⦕୰ኸ࠿ࡽษ⦕ࡲ
࡛ࡢ㊥㞳ࢆ8➼ศࡋ㸪ษ⦕ࡼࡾ⮫ᗋⓗṑෙ㛗ࡢ1/8㸪
1/2㸪7/8㸪ࡢ㧗ࡉࡢ၁㠃ࡢ㏆㐲ᚰⓗ୰ኸ㸪࠾ࡼࡧ၁ഃṑ⫗⦕ࡢ୰ኸ (MG)ࡢィ4Ⅼ࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ SS-OCT࡟ࡼࡿ࢚ࢼ࣓ࣝ㉁ཌᚄࡢ

ᐃ⢭ᗘࡣ㸪ୖ

㢡୰ษṑ㸪ୖ㢡ഃษṑࡢ࡝ࡕࡽࡶィ ㄗᕪࡢ୰ኸ
್ࡀ0.04mm࡛࠶ࡗࡓ㸬ṑ✀㸪ィ 㒊఩࡟ࡼࡗ࡚ィㄗᕪ࡟᭷ពᕪࡣㄆࡵࡽࢀࡎ (ANOVA; P>0.05)㸪
SS-OCTࡣ⮫ᗋⓗ࡟᭷⏝࡞ ᐃ⢭ᗘ࡛࠶ࡗࡓ㸬⮫ᗋṑෙ࡛ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄࢆ ᐃࡋࡓ⿕㦂⪅
ࡣ59ྡ࡛㸪⿕㦂ṑᩘࡣୖ㢡୰ษṑ59ᮏ (ᖹᆒᖺ㱋
40.20㸹22㹼69ṓ) 㸪ୖ㢡ഃษṑ49ᮏ (ᖹᆒᖺ㱋
39.16 㸹 22 㹼 69 ṓ ) 㸪 ୖ 㢡 ≟ ṑ 36 ᮏ ( ᖹ ᆒ ᖺ 㱋
36.06㸹22㹼68ṓ)࡛࠶ࡗࡓ㸬඲ᖺ㱋࡟࠾ࡅࡿ࢚ࢼ࣓
ࣝ㉁ཌᚄࡢᖹᆒ್ཬࡧᶆ‽೫ᕪࢆᅗ࡟♧ࡍ㸬୍ඖ㓄⨨ศᩓศᯒࡢ⤖ᯝ㸪MG㒊࡛ࡣୖ㢡୰ษṑࡼࡾࡶୖ㢡≟ṑ࡛ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄࡀ᭷ព࡟ᑠࡉ࠿ࡗࡓ㸬ྛᖺ௦ู࡛ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄ࡛ࡣ㸪ᖺ㱋ࡀୖࡀࡿ࡜࢚ࢼ࣓ࣝ㉁ཌᚄࡣⷧࡃ࡞ࡿഴྥࢆ♧ࡋ㸪50㹼60ṓྎࡢṑ㢁㒊࡟ࡼࡾ㏆࠸7/8㒊࡛ࡢ࢚ࢼ࣓ࣝ㉁ཌᚄ
ࡣ୰ษṑ0.49±0.14mm㸪ഃษṑ0.51±0.17mm㸪≟ṑ
0.56±0.24mm࡛࠶ࡗࡓ㸬௨ୖࡼࡾ㸪୍⯡ⓗ࡞࣑ࣛࢿ࣮ࢺ࣋ࢽ࢔ࡢṑ㢕㒊௜㏆࡛ࡢᙧᡂ㔞0.3mm࡛ࡣ㸪≉࡟≟ṑ࡛㇟∳㉁ࡢ
㟢ฟࡀᠱᛕࡉࢀ㸪50㹼60ṓྎ࡛ࡣ7/8㒊௜㏆࡟࠾࠸࡚㇟∳㉁ࡀ㟢ฟࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬඲ᖺ㱋࡟࠾ࡅࡿ࢚ࢼ࣓ࣝ㉁ཌᚄ
ϫ㸬 ᩥ⊩1) Hariri I, Sadr A, Shimada Y, et al. Effects ofstructural orientation of enamel and dentine on lightattenuation and local refractive index: An opticalcoherence tomography study. Journal of dentistry2012; 40: 387-96.

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第2日

日補綴会誌

第 3 会場

7･124 回特別号，2015

一般口演発表

2 ─ 3 ─ 5ࢫ࣐࢖ࣝ᫬࡟㔠ᒓⰍࡀ㟢ฟࡋࡓཱྀඖ෗┿࡟ᑐࡍࡿὀどⅬࡢほ
ᐹ

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‫ۑ‬ᒣᮏ┿⏤㸪㫽஭ඞ඾㸪኱Ἑ㈗ஂ㸪⸨஭Ꮥᨻ㸪ሐ ⩏ᩥ㸪బ⸨ṇᶞ㸪⏣୰㡰Ꮚ㸪⏣୰ᫀ༤኱㜰ṑ⛉኱Ꮫ᭷ṑ⿵⥛ညྜᏛㅮᗙ
      !"   $@  \^_ `^ {|_^ }_^ _  \^ ^ _{^ _{   }"   $  $$ ^ {  Ϩ㸬 ┠ⓗᝈ⪅ࡣ㸪ṑࡀᑂ⨾ⓗ࡛࠶ࡿࡇ࡜ࢆᙉࡃᮃࡴࡼ࠺࡟
࡞ࡗ࡚࠸ࡿ  㸬ࡋ࠿ࡋ㸪ேࡀᑐ㠃᫬࡟┦ᡭࡢཱྀඖࢆ
ぢࡿሙྜ㸪࡝ࡢ㒊఩࡟ど⥺ࡀὀࡀࢀ࡚࠸ࡿࡢ࠿ࡣ᫂
ࡽ࠿࡛ࡣ࡞࠸㸬㔠ᒓⰍࡸኚⰍṑ࡞࡝㸪ṑ⛉་ᖌࡀᑂ⨾ⓗ࡛࡞࠸࡜⪃࠼࡚࠸ࡿ㒊఩࡟ேࡢど⥺ࡣὀࡀࢀ࡚
࠸ࡿࡢ࠿ࢆᐈほⓗ࡟▱ࡿࡇ࡜ࡣ㸪ᑂ⨾ಟ᚟ࡢᚲせᛶ࡟ᙺ❧ࡘ࡜⪃࠼ࡽࢀࡿ㸬ᮏ◊✲࡛ࡣ㸪ࢫ࣐࢖ࣝ᫬࡟㔠ᒓⰍࡀ㟢ฟࡋࡓ෗┿ࡢど⥺ศᯒࢆ⾜࠺ࡇ࡜࡟ࡼࡗ࡚㸪ཱྀඖࡢ࡝ࡇࢆὀどࡋ࡚࠸ࡿࡢ࠿ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ⿕᳨⪅ࡣ㸪ṑ⛉་⒪㛵ಀ⪅ࡸᝈ⪅࡛ࡣ࡞࠸ᡂே
ྡ㸦⏨ᛶྡ㸪ዪᛶྡ㸪ᖹᆒᖺ㱋ṓ㸧࡜ࡋࡓ㸬࢔࢖ࢺࣛࢵ࢟ࣥࢢ࡟ࡣ㸪࢔࢖ࢺࣛࢵ࣮࢝
㸦_  㸪_ 〇㸧࠾ࡼࡧゎᯒࢯࣇࢺ࢙࢘࢔
㸦_     㸪_ 〇㸧ࢆ⏝࠸ࡓ㸬⿕᳨⪅࡟ᥦ♧ࡍࡿ่⃭⏬ീ࡜ࡋ࡚㸪ࢫ࣐࢖ࣝ᫬࡟ᑠ
⮻ṑ㒊࡟㔠ᒓⰍࡀ㟢ฟࡋࡓྡࡢཱྀඖ෗┿ࢆᯛࡎࡘ⏝ពࡋ㸪ࢹ࢕ࢫࣉࣞ࢖ୖ࡟ྛ⏬ീࢆ⛊㛫ࣛࣥࢲ࣒࡟⾲♧ࡋࡓ㸬⿕᳨⪅࡟ࡣࠕࣜࣛࢵࢡࢫࡋ࡚⏬㠃࡟⾲♧ࡉࢀࡿ⏬ീࢆ⮬⏤࡟ぢ࡚࠾࠸࡚ࡃࡔࡉ࠸ࠖ
࡜ᣦ♧ࡋࡓ㸬ィ 㒊఩࡜ࡋ࡚㸪㉥၁ෆ⦕࡛ᅖࢇࡔ
㒊఩ࢆ㸪ୖ㢡ഃษṑࡢ㐲ᚰ㠃᭱኱㇏㝯㒊ࢆቃ⏺࡟ศ๭ࡋ㸪ྑഃ㸪ษṑ㒊࠾ࡼࡧᕥഃ࡜タᐃࡋࡓ㸬่⃭⏬ീ࠾ࡼࡧィ 㒊఩ࡢ୍౛ࢆᅗ࡟♧ࡍ㸬᳨ウ㡯┠ࡣ㸪࠾ࡼࡧ␒┠࡟ぢࡓィ 㒊఩࡟࠾ࡅࡿ⿕᳨⪅ᩘ㸪ྛィ 㒊఩ࢆぢࡓᅇᩘ࠾ࡼࡧྛィ 㒊఩࡟࠾ࡅࡿὀどⅬࡢྜィ೵␃᫬㛫࡜ࡋࡓ㸬ྛィ 㒊఩ࢆぢࡓᅇᩘ࠾ࡼࡧྛィ 㒊఩࡟࠾ࡅࡿὀどⅬࡢྜィ೵␃᫬㛫࡟ࡘ࠸࡚ࡣ㸪⤫ィᏛⓗゎᯒ࡜ࡋ࡚}  ᳨ᐃࢆ⾜ࡗࡓᚋ㸪᭷ពᕪࡀㄆࡵࡽࢀࡓሙ
ྜ࡟ࡣ㸪᭷ពỈ‽ࢆㄪᩚࡋࡓ$"ࡢ➢ྕ௜ࡁ㡰఩᳨ᐃ࡛ከ㔜ẚ㍑ࢆ⾜ࡗࡓ㸦Ș㸧㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ࠾ࡼࡧ␒┠࡟ὀどࡋࡓィ 㒊఩࡟࠾ࡅࡿ⿕᳨⪅ᩘ࡛ࡣ㸪࡯࡜ࢇ࡝ࡢ⿕᳨⪅ࡀࡲࡎษṑ㒊ࢆぢࡓ㸬ࡘࡂ࡟㔠ᒓⰍࡢ㟢ฟࡀ኱ࡁ࡞ഃࢆぢࡓ⿕㦂⪅ࡀከ࠿ࡗࡓ㸦ᅗ㸧㸬ྛィ 㒊఩ࢆぢࡓᅇᩘ࡛ࡣ㸪ࡍ࡭࡚ࡢ่⃭⏬ീ࡟࠾࠸࡚ษṑ㒊ࡀᕥྑഃ࡟ẚ࡭᭷ព࡟ከ࠿ࡗࡓ㸬㔠ᒓⰍࡢ㟢ฟࡋࡓྑഃ࠾ࡼࡧᕥഃ࡟ࡣ᭷ព࡞ᕪࡣ
ㄆࡵࡽࢀ࡞࠿ࡗࡓࡀ㸪㟢ฟ㠃✚ࡀ኱ࡁ࠸ഃ࡛ᅇᩘ
ࡀከࡃ࡞ࡿഴྥࡀㄆࡵࡽࢀࡓ㸦ᅗ㸧㸬  ྛィ 㒊఩࡟࠾ࡅࡿὀどⅬࡢྜィ೵␃᫬㛫࡛ࡣ㸪ࡍ࡭࡚ࡢ่⃭⏬ീ࡟࠾࠸࡚ษṑ㒊ࡀᕥྑഃ࡟ẚ࡭᭷ព࡟ᘏ㛗ࡋࡓ㸬㔠ᒓⰍࡢ㟢ฟࡋࡓྑഃ࠾ࡼࡧᕥ
ഃ࡟ࡣ᭷ព࡞ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓࡀ㸪㟢ฟ㠃✚ࡀ኱ࡁ࠸ഃ࡛᫬㛫ࡀ㛗ࡃ࡞ࡿഴྥࡀㄆࡵࡽࢀࡓ
㸦ᅗ㸧㸬
௨ୖ࠿ࡽ㸪୍⯡ᡂே࡛㸪ࢫ࣐࢖ࣝ᫬࡟㔠ᒓⰍࡀ㟢ฟࡋࡓ෗┿࡟࠾࠸࡚㸪ษṑ㒊ࢆ᭱ࡶࡼࡃὀどࡋ㸪ḟ࠸࡛㔠ᒓⰍࡢ㟢ฟࡀ኱ࡁ࡞㒊఩ࢆὀどࡍࡿഴྥࡀㄆࡵࡽࢀࡓ㸬
䠄ྡ䠅

ϭϮ
ϭϬ
ϴ
ϲ
ϰ
Ϯ
Ϭ

ษṑ㒊䛾䜏 ษṑ㒊їྑഃ ษṑ㒊їᕥഃ ᕥഃїษṑ㒊ᅗ   ่⃭⏬ീ  ࠾ࡼࡧ  ᅗ    ࠾ࡼࡧ  ␒┠࡟ὀどࡋࡓィ ィ 㒊఩ࡢ୍౛      㒊఩࡟࠾ࡅࡿ⿕᳨⪅ᩘ㸦่⃭⏬ീ 㸧ᅗ  ྛィ 㒊఩ࢆぢࡓᅇᩘ   ᅗ  ྛィ 㒊఩࡟࠾ࡅࡿὀどⅬࡢ㸦่⃭⏬ീ 㸧          ྜィ೵␃᫬㛫㸦่⃭⏬ീ 㸧ϫ㸬ᩥ⊩   ᳃ ᬛᜨᏊ㸪Ṋ஭඾Ꮚ㸪῰㇂⪔ྖ࡯࠿㸬኱ᡭ௻ᴗ໅ົ⪅ࡢཱྀ⭍ࡢ⌧≧࡟ᑐࡍࡿ‶㊊ᗘ࡟ࡘ࠸࡚̿➨ሗ ๓ṑ㒊ࡢᑂ⨾ᛶ࡟ᑐࡍࡿព㆑
ㄪᰝ̿㸬ṑ⛉ᑂ⨾ 㸹  㸸

− 172 −

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表

2 ─ 3 ─ 6㛗ᓮ኱Ꮫ⑓㝔ṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮ᑓ㛛እ᮶ཷデᝈ⪅ࡢᐇែ‫ۑ‬㯮ᮌ၏ᩥ㸪ྜྷ⏣࿴ᘯ㸪⏣୰฼ె㸪໭ᕝᖾ㑻㸪ᘅἑᜨ௓㸪ᒣ⏣┿⥴㸪ᑎ㔝ඖ༤㸪ᮧ⏣ẚ࿅ྖ

㛗ᓮ኱Ꮫ኱Ꮫ㝔་ṑ⸆Ꮫ⥲ྜ◊✲⛉ṑ⛉⿵⥛Ꮫศ㔝㸪་⒪ἲே࿴ග఍ᜨᑑ⑓㝔        {







 ` _^\ `^_{^`|\^  |`^\^_ 㸪       $   ^  $ $$ $ ^ {   Ϩ㸬 ┠ⓗ ⌧ᅾ㸪ṑ⛉⏝ᮦᩱ࢔ࣞࣝࢠ࣮ࡣ㸪ከࡃࡢṑ⛉㛵ಀ⪅ࡢࡳ࡞ࡽࡎ㸪࣓ࢹ࢕࢔ࡸ࢖ࣥࢱ࣮ࢿࢵࢺ➼ࡢᙳ㡪࡛ᝈ⪅ࡢ୰࡛ࡶ࿘▱ࡉࢀ࡚ࡁࡓ㸬ᡃࠎࡣ㸪ࡇࢀࡲ࡛㸪ṑ⛉⏝㔠ᒓ࢔ࣞࣝࢠ࣮ᝈ⪅࡟㛵ࡍࡿ⮫ᗋ␿Ꮫㄪᰝࡢ⤖ᯝࡸṑ⛉⏝㔠ᒓ࢔ࣞࣝࢠ࣮ᝈ⪅ࡢ⮫ᗋᡂᯝ➼ࢆሗ࿌ࡋ࡚ࡁࡓ㸬ྂࡃࡣᖺࡼࡾṑ⛉⏝㔠ᒓ࢔ࣞࣝࢠ࣮␲࠸ᝈ⪅ࡢຍ⒪࠿ࡽ㸪ᖺ࡟
ࡣ㸪㛗ᓮ኱ᏛṑᏛ㒊㝃ᒓ⑓㝔࡟ṑ⛉ᮦᩱ࢔ࣞࣝࢠ
࣮ᐊࢆ㛤タࡋ㸪⌧ᅾ࡟⮳ࡿࡲ࡛ṑ⛉ᮦᩱ࢔ࣞࣝࢠ
࣮ᝈ⪅ࡢຍ⒪ࢆ⾜ࡗ࡚࠸ࡿ㸬ᖺ㸪ᖺࡢ
ᮏᏛ఍஑ᕞᨭ㒊Ꮫ⾡ㅮ₇఍࡛ࡣ㸪ṑ⛉ᮦᩱ࢔ࣞࣝ
ࢠ࣮㛵㐃ཷデᝈ⪅ࡢᐇែࢆሗ࿌ࡋ࡚࠾ࡾ㸪௒ᅇࡣ㸪ṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮እ᮶ཷデᝈ⪅ࡢᐇែࢆᢕᥱࡍ
ࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ࡚㸪㐣ཤሗ࿌௨㝆ࡢཷデᝈ⪅ࢆᑐ㇟࡜ࡋࡓ⮫ᗋ␿Ꮫㄪᰝࢆ⾜ࡗࡓ㸬ϩ㸬 ᪉ἲ ṑ⛉⏝㔠ᒓ࢔ࣞࣝࢠ࣮ࡲࡓࡣṑ⛉ᮦᩱ࢔ࣞࣝࢠ
࣮ࡢ␲࠸࡛㸪ᖺ᭶࠿ࡽᖺ᭶ࡲ࡛࡟㛗ᓮ኱Ꮫ⑓㝔⩏ṑ⿵⥛἞⒪ᐊṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮ᑓ㛛እ᮶ࢆཷデࡋࡓึデᝈ⪅㸪ྡ㸦෌ึデᝈ⪅ྡࢆྵࡴ㸧ࢆᑐ㇟࡜ࡋ࡚㸪እ᮶࢝ࣝࢸグ㍕஦㡯ࡼࡾ㸪ึデ᪥㸪ึデ᫬ᖺ㱋㸪ᛶู㸪ࣃࢵࢳࢸࢫࢺ⤖ᯝ㸪ཱྀ⭍ෆእࡢ⮫ᗋ⑕≧㸪ཱྀ⭍ෆ㔠ᒓಟ᚟≀ᡂศศᯒ⤖ᯝ㸪἞⒪ࡢ⤒㐣࡞࡝ࢆᢳฟࡋࡓ㸬 㐣ཤࡢሗ࿌࡜ྠᵝ㸦ᅗ㸧࡟㸪እ᮶ึデᝈ⪅ྡࢆ㔠ᒓ࢔ࣞࣝࢠ࣮ᝈ⪅⩌㸦ṑ⛉⏝㔠ᒓ࢔ࣞࣝࢠ࣮
ᝈ⪅⩌㸪ឤస㔠ᒓ᭷ࡾᝈ⪅⩌㸧㸪⿕␲ᝈ⪅⩌㸦㔠ᒓ௨እࡢᮦᩱ࡟ᑐࡍࡿ࢔ࣞࣝࢠ࣮ᝈ⪅⩌㸪ឤస㔠ᒓ࡞ࡋᝈ⪅⩌㸧࡟ศࡅ㸪ㄪᰝ᳨ウ⾜ࡗࡓ㸬 ࡞࠾㸪ᮏ◊✲ࡣ㛗ᓮ኱Ꮫ⑓㝔⮫ᗋ◊✲೔⌮ጤဨ఍ࡢᢎㄆ㸦ᢎㄆ␒ྕ㸧ࢆཷࡅ࡚࠸ࡿ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᮏ◊✲ᮇ㛫୰ࡢṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮እ᮶ึデᝈ⪅ࡣ㸪⏨ᛶྡ㸪ዪᛶྡ㸪ྜィྡ࡛࠶ࡗࡓ㸬୰࡟ࡣ㸪⑕≧㍍ᛌ⤊஢࡛㸪෌ࡧ⿵⥛἞⒪ࡀᚲせ࡟࡞ࡗࡓࡓࡵ෌ึデ࡜࡞ࡗࡓᝈ⪅ࡀྡ㸪㏆་࡛ṑ⛉἞⒪ࢆཷࡅࡓᚋ㸪⑕≧ࡀᝏ໬ࡋࡓࡓࡵ෌ึデ࡜࡞ࡗࡓᝈ⪅ࡀྡᏑᅾࡋࡓ㸬ࡑࡢྡࡢᝈ⪅ࡣ㸪㏆་࡛⿦╔ࡉࢀࡓ⿵⥛≀ࡢᡂศศᯒࢆ⾜ࡗࡓ⤖ᯝ㸪ឤస㔠ᒓࢆྵࡴ⿵⥛≀࡜ุ᫂ࡋࡓࡓࡵ㸪ࡑࢀࡽࡢ㝖ཤ⒪ἲ࡟ࡼࡾ⑕≧ࡀᨵၿࡋࡓ㸬 ึデ᫬ᖺ㱋ࡣ㸪⏨ዪ࡜ࡶ࡟ṓ௦ࡀ᭱ࡶከࡃ㸪⏨ᛶྡ㸪ዪᛶྡ㸪ḟ࠸࡛ṓ௦㸪ṓ௦࡛㸪ࡇࡢഴྥࡣ㸪๓ᅇࡢሗ࿌࡜㢮ఝࡋ࡚࠸ࡓ㸬ࡇࡢᖺ௦ࡢཷデᝈ⪅ࡀከ࠸ࡇ࡜ࡣ㸪኱Ꮫ⑓㝔ࡢデ⒪᫬㛫࡜ࡢ㛵ಀࡀ࠶ࡿࡼ࠺࡟ᛮࢃࢀࡿ㸬 ཱྀ⭍ෆ⮫ᗋ⑕≧ࡣ㸪ᡥᖹⱏⓄࡀ᭱ࡶከࡃ㸪ḟ࠸࡛⯉③⑕࡛࠶ࡗࡓ㸬๓ᅇࡢሗ࿌࡜ẚ࡭࡚㸪ཱྀ⭍ෆ㐪࿴ឤࡸཱྀࡢ୰ࡢ③ࡳ㸪ࡦࡾࡦࡾ㸦ࡨࡾࡨࡾ㸧ឤ
ࢆ୺ッ࡟᮶㝔ࡍࡿᝈ⪅ࡀከ࠸ഴྥࡀ࠶ࡗࡓ㸬ཱྀ⭍እ⮫ᗋ⑕≧࡛ࡣ㸪ᤸ㋲⮋⑁⑕ࡀ᭱ࡶከࡃ㸪ḟ࠸࡛‵⑈㸪᥋ゐᛶ⓶⭵⅖ࡢ㡰࡛࠶ࡗࡓ㸬ࡲࡓ㸪ཱྀ⭍ෆእ࡟⮫ᗋ⑕≧ࡢ࡞࠸᳨ᰝᕼᮃࡢᝈ⪅ࡀྡࡶᏑᅾ
ࡋࡓ㸬ࡇࢀࡣ㸪ṑ⛉㔠ᒓ࢔ࣞࣝࢠ࣮ࡀᗈࡃ࿘▱ࡉࢀ࡚ࡁࡓࡇ࡜ࡀᙳ㡪ࡋࡓ࡜⪃࠼ࡽࢀࡿ㸬













   ṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮እ᮶ึデᝈ⪅ࡢศ㢮ϫ㸬 ᩥ⊩  ᑎ㔝ඖ༤㸪୰ᮧⱱ㸪ᑠụ㯞㔛࡯࠿㸬⮫ᗋ࡟࠾ࡅࡿ㔠ᒓ࢔ࣞࣝࢠ࣮ᝈ⪅ࡢㄪᰝ̾㐣ཤ ᖺ㛫ࡢᐇ⦼̾㸬⿵⥛ㄅ ᅇ≉ูྕ  㯮ᮌ၏ᩥ㸪ᰘ⏣᫂Ꮚ㸪ᖹᒣ㍤ஂ࡯࠿㸬ṑ⛉ᮦᩱ࢔ࣞࣝࢠ࣮ᐊཷデᝈ⪅ࡢᐇែ̾㐣ཤᖺ㛫ࡢ㞟ィㄪᰝ̾㸬⿵⥛ㄅ 

− 173 −

第2日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表2─3─7ࢣࣛࢳࣀࢧ࢖ࢺ༢⊂ᇵ㣴࡟ࡼࡿཱྀ⭍⢓⭷ゅ໬ࣔࢹࣝ‫ۑ‬ᯇᾆᑦᚿ㸪℩ᑿⓡ㸪᭷㤿⿱Ꮚ㸪Ỉ⏫ᰤ⨾⌮㸪⠛ᓮ㝧௓㸪✄஭ဴ୍ᮁ*㸪బ⸨༤ಙ⚟ᒸṑ⛉኱Ꮫညྜಟ᚟Ꮫㅮᗙෙᶫ⩏ṑᏛศ㔝㸪*⏕యᵓ㐀Ꮫㅮᗙᶵ⬟ᵓ㐀Ꮫศ㔝
A model of oral mucosal keratinization by a feeder- and connective tissue-free culture of keratinocytes
Matsuura T, Seo A, Arima Y, Mizumachi E, Shinozaki Y, Inai T*, Sato H
Section of Fixed Prosthodontics, Department of Oral Rehabilitation, Fukuoka Dental College㸪
*Section of Functional Structure, Department of Morphological Biology, Fukuoka Dental CollegeϨ㸬 ┠ⓗ እ⛉౵くࢆక࠺ṑ⫗ቑ኱⾡ࡣᝈ⪅࡟ᩗ㐲ࡉࢀࡿࡇ࡜ࡀከ࠸㸬ཱྀ⭍⢓⭷ࡢゅ໬⌧㇟ࡢศᏊ࡛ࣞ࣋ࣝ
ࡢ࣓࢝ࢽࢬ࣒ࡀ᫂ࡽ࠿࡟࡞ࢀࡤ㸪ࡼࡾእ⛉౵くࡢᑡ࡞࠸ṑ⫗ቑ኱⾡ࢆ㛤Ⓨ࡛ࡁࡿྍ⬟ᛶࡀ࠶ࡿ㸬㏆ᖺࡢὙ⦎ࡉࢀࡓཱྀ⭍⢓⭷୕ḟඖᇵ㣴ࣔࢹࣝࡣ㸪ࢣࣛࢳࣀࢧ࢖ࢺ௨እ࡟㸪⥺⥔ⱆ⣽⬊࡞࡝ࡢfeeder cell࡜⤖ྜ⤌⧊㸦࠶ࡿ࠸ࡣࡑࡢ௦⏝ᮦᩱ㸧ࢆᚲせ࡜ࡍࡿ㸬ࡇࢀࡽࡢࣔࢹࣝࡣṑ⫗࡟㢮ఝࡋࡓ⣽⬊ࢩ࣮ࢺࢆస〇࡛ࡁࡿ཯㠃㸪ࢣࣛࢳࣀࢧ࢖ࢺ㸪feeder cell㸪⤖ྜ⤌⧊ࡢ3⪅ࡢ┦஫స⏝ࡀୖ⓶ࡢゅ໬⌧㇟ࡢศᏊ࡛ࣞ࣋ࣝࡢゎ᫂ࢆᅔ㞴࡟ࡍࡿ1)㸬ࢣࣛࢳࣀࢧ࢖ࢺ༢
⊂ᇵ㣴࡟ࡼࡿゅ໬ࣔࢹࣝ2)ࡀ࠶ࢀࡤࡇࡢၥ㢟ࢆゎỴ࡛ࡁࡿࡀ㸪ᡃࠎࡢ▱ࡿ㝈ࡾཱྀ⭍⢓⭷࡟࠾ࡅࡿࡑࡢ
ࡼ࠺࡞ࣔࢹࣝࡢሗ࿌ࡣ࡞࠸㸬ᡃࠎࡣཱྀ⭍⢓⭷⏤᮶ࢣࣛࢳࣀࢧ࢖ࢺࡢ༢⊂ᇵ㣴࡟ࡼࡗ࡚㸪ゅ໬㔜ᒙᡥᖹୖ⓶ࢩ࣮ࢺࢆᙧᡂࡍࡿࣔࢹࣝࡢస〇ࢆヨࡳࡓ㸬ϩ㸬 ᪉ἲ ᒕẅ┤ᚋࡢ㣗⏝ࣈࢱࡢṑ⫗࠾ࡼࡧṑᵴ⢓⭷࠿ࡽศ㞳ࡋࡓࢣࣛࢳࣀࢧ࢖ࢺࢆࡑࢀࡒࢀᐇ㦂࡟౪ࡋࡓ㸬
CnT-57㸦progenitor cell targeted defined medium with
0.07 mM calcium and 6 μg/ml bovine pituitary extract,
CELLnTEC, Bern, Switzerland㸧࡛4~6௦⥅௦ᇵ㣴ࡋࡓࢣࣛࢳࣀࢧ࢖ࢺࢆ24✰ࣉ࣮ࣞࢺෆࡢ࢖ࣥࢧ࣮ࢺ
㸦0.4 μm pore㸧ୖ࡟᧛✀ࡋ㸪ࢥࣥࣇ࢚ࣝࣥࢺ࡟࡞ࡿ ࡲ ࡛ ᇵ 㣴 ࡋ ࡓ 㸬 ᇵ ᆅ ࢆ CnT-02-3D 㸦 3D prime
medium, CELLnTEC㸧࡟஺᥮ࡋ㸪⣽⬊ࢩ࣮ࢺࡢ᭱ୖ
㠃ࡀair/liquid interface࡜࡞ࡿࡼ࠺ᇵᆅ㔞ࢆㄪᩚࡋ㸪୕ḟඖᇵ㣴ࢆ㛤ጞࡋࡓ㸬୕ḟඖᇵ㣴㛤ጞ1㐌ᚋ࡜2㐌ᚋࡢୖ⓶ࢩ࣮ࢺ࠿ࡽ෾⤖ษ∦ࢆస〇ࡋ㸪ࢣࣛࢳࣥ㸦K㸧࡟ᑐࡍࡿච␿⤌⧊Ꮫⓗศᯒࢆ⾜ࡗࡓ㸬ゅ໬ୖ⓶࡟≉␗ⓗ࡟Ⓨ⌧ࡍࡿK1࡜K10㸪࠾ࡼࡧ㠀ゅ໬ୖ⓶࡟≉␗ⓗ࡞K4࡜K13ࢆࢱ࣮ࢤࢵࢺ࡜ࡋࡓ㸬ṑᵴ⢓⭷⏤᮶ࢣࣛࢳࣀࢧ࢖ࢺࡢୖ⓶ࢩ࣮ࢺ㸦AMS㸧࡟࠾࠸࡚ࡶ㸪ྠᵝࡢୖ⓶ᙧᡂࣉࣟࢭࢫࡀㄆࡵࡽࢀ
ࡓ㸬 K1ࡢᒁᅾࣃࢱ࣮ࣥࡣ㸪GS㸪AMS࡜ࡶ࡟ᮏ᮶ࡢṑ⫗࡛ࡢᒁᅾࣃࢱ࣮ࣥ࡜୍⮴ࡋ࡚࠸ࡓ㸬ࡋ࠿ࡋ㸪K10
ࡢᒁᅾࡣGS࡛ㄆࡵࡽࢀࡓࡶࡢࡢ㸪ゅ໬ࡋࡓAMS࡛ࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬ࡲࡓ㸪ゅ໬ୖ⓶࡟ࡣⓎ⌧ࡋ࡞࠸࡜ࡉࢀࡿK4࡜K13ࡣゅ໬๓㸦1㐌㛫ᚋ㸧ࡢGS࡜
AMS࡟Ꮡᅾࡋ㸪ゅ໬ᚋ㸦2㐌㛫ᚋ㸧࡛ࡶAMS࡟࠾ࡅࡿK4ࢆ౛እ࡜ࡋ࡚㸪K4࡜K13ࡢᒁᅾࡀほᐹࡉࢀࡓ㸬 ௨ୖࡢ⤖ᯝࡼࡾ㸪feeder cellࡸ⤖ྜ⤌⧊ࢆ⏝࠸࡞ࡃ࡚ࡶ㸪ᮏἲ࡟♧ࡉࢀࡿ᮲௳ୗ࡛ࡢཱྀ⭍⢓⭷⏤᮶ࢣࣛࢳࣀࢧ࢖ࢺ༢⊂ࡢᇵ㣴࡟ࡼࡗ࡚㸪ゅ໬㔜ᒙᡥᖹୖ⓶ᵝࡢୖ⓶ࢩ࣮ࢺࡢస〇ࡀྍ⬟࡟࡞ࡿࡇ࡜ࡀ
♧ࡉࢀࡓ㸬ࡲࡓ㸪Kࡣᚲࡎࡋࡶゅ໬⌧㇟ࡢ࣐࣮࣮࢝
࡜ࡋ࡚㐺ษ࡛ࡣ࡞࠸ྍ⬟ᛶࡀ࠶ࡿࡇ࡜࡜㸪ṑᵴ⢓⭷ࡢࢣࣛࢳࣀࢧ࢖ࢺ࡟ࡣゅ໬ୖ⓶ࢆᙧᡂࡍࡿ₯ᅾ⬟ຊࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ᮏἲࡣཱྀ⭍⢓⭷ࡢ
ゅ໬ࡢᢚไᶵᗎࢆ᥈ồࡍࡿ᭷┈࡞ᡭἲ࡜࡞ࡿྍ⬟
ᛶࡀ࠶ࡿ㸬
ϫ㸬 ᩥ⊩
1) Poumay Y, Coquette A. Modelling the humanepidermis in vitro: tools for basic and appliedresearch. Arch Dermatol Res 2007; 298: 361-369.
2) Segrelles C, Holguin A, Hernandez P, Ariza JM,
Paramio JM, Lorz C. Establishment of a murine
epidermal cell line suitable for in vitro and in vivo
skin modelling. BMC Dermatol 2011; 11: 9-16.

Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ṑ⫗⏤᮶ࢣࣛࢳࣀࢧ࢖ࢺࡢୖ⓶ࢩ࣮ࢺ㸦GS㸧ࡣ
1㐌㛫࡛㔜ᒙ໬㸦basal layer࡜suprabasal layerࡢᙧᡂ㸧ࡋ㸪2㐌㛫ᚋ࡛ࡣkeratinized layerࡶᙧᡂࡉࢀ㸪ゅ໬㔜ᒙᡥᖹୖ⓶ᵝࡢᵓ㐀࡜࡞ࡗࡓ㸬ពእ࡞ࡇ࡜࡟㸪− 174 −

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2─3─8ⱞ࿡ཷᐜయ㑇ఏᏊⓎ⌧㔞ࡢ᳨ウ‫ۑ‬ఀ⸨ 㞙*㸪ᑠᓥ๛ᚿ*㸪ᰘཎᰤ୍㑻*㸪㛵᰿㈗ோ**㸪బ⸨ග୍**㸪Ọ⏣⿱⣖**㸪㕥ᮌ ⩧**㸪㧘ᒣᾈྐ**㸪ᮧᓥ┤㐨**㸪㛵᰿⚽ᚿ*,**㸪ᒣ᳃ᚭ㞝*,**㸪⏣୰⁠ஂ****ዟ⩚኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ཱྀ⭍ᶵ⬟ᅇ᚟Ꮫᑓᨷ㸪**ዟ⩚኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫㅮᗙ***㛵㉺ᨭ㒊
Gene Expressions of Bitter Taste Receptors
Ito J *㸪Kojima T*㸪Shibahara E*㸪Sekine T**㸪Sato K**㸪Nagata Y**㸪Suzuki S**㸪Takayama H**㸪
Murashima N**㸪Sekine H*,**㸪Yamamori T*,**㸪Tanaka S***
*Department of Oral Rehabilitation㸪Ohu University Graduate School of Dentistry㸪**Department of Prosthodontic Dentistry㸪Ohu University School of Dentistry㸪***Kan-etsu BranchϨ㸬 ┠ⓗ 㣗஦࡟㛵㐃ࡍࡿQOLྥୖ࡟ࡣ㸪࿪ᄮᶵ⬟㸪ᄟୗᶵ⬟࡟ຍ࠼㸪࿡ぬࢆ㐺ษ࡟ཷᐜ࡛ࡁࡿࡇ࡜ࡀồࡵࡽࢀࡿ㸬ࡇࢀࡲ࡛ᙜㅮᗙ࡛ࡣ࿡ぬཷᐜᶵᵓゎ᫂ࡢ୍⎔࡜ࡋ࡚㸪ⱞ࿡≀㉁࡛࠶ࡿ࢟ࢽ࣮ࢿ࡜㛵㐃ࡍࡿၚᾮࢱࣥࣃࢡHistatin 5ࢆ᳨ฟ1)ࡋ㸪Histatin 5ࡀ࢟ࢽ࣮ ࢿ ࡜ ⤖ ྜ ࡍ ࡿ 2) ࡇ ࡜ ࡸ 㸪 ୍ 㐣 ᛶ ࡟ ཱྀ ⭍ ෆ ࡢHistatin 5㔞ࢆቑຍࡉࡏࡿ࡜ⱞ࿡㜈್ࡀపୗࡍࡿ2)ࡇ
࡜ࢆሗ࿌ࡋ࡚ࡁࡓ㸬ࡲࡓreal time RT-qPCR࡟ࡼࡾ9✀㢮ࡢ࢟ࢽ࣮ࢿཷᐜయ㑇ఏᏊࡢⓎ⌧㔞ࢆㄪ࡭㸪࢟ࢽ࣮ࢿ࡟ࡼࡿⱞ࿡ឤཷᛶࡢప࠸⩌࡛ࡣTAS2R7ࡢⓎ⌧ࡀ᭷ព࡟ᑡ࡞࠸3)ࡇ࡜㸪ཷᐜయ㑇ఏᏊࡢⓎ⌧㔞㛫࡟┦㛵ࡀࡳࡽࢀࡿ3)ࡇ࡜ࢆሗ࿌ࡋ࡚ࡁࡓ㸬୍᪉㸪ⱞ࿡ཷᐜᶵᵓ࡟ࡘ࠸࡚ࡣ୙᫂࡞ⅬࡀᮍࡔከࡃᏑᅾࡋ㸪ⱞ࿡ཷᐜయࡣ࢜ࣜࢦ࣐࣮ࢆᙧᡂࡍࡿ
ࡇ࡜࡛㸪ⱞ࿡ࡢཷᐜ࡟㛵୚ࡍࡿྍ⬟ᛶࡀ࠶ࡿ࡜࠸
࠺ሗ࿌4)ࡀ࠶ࡿ㸬ᮏ◊✲࡛ࡣ㸪⯉⾲ᒙࡢ⤌⧊ࢆ᧿㐣࡟ࡼࡾ᥇ྲྀࡋ㸪real time RT-qPCR࡟ࡼࡾ೺ᖖ⪅࡟ẚ㍑ⓗ㧗⋡࡟ࡳࡽࢀࡿ7✀㢮ࡢⱞ࿡ཷᐜయ㑇ఏᏊ࠾
ࡼࡧ9✀㢮ࡢ࢟ࢽ࣮ࢿཷᐜయ㑇ఏᏊࡢⓎ⌧㔞ࢆࡑࢀࡒࢀィ ࡋ࡚㸪ཷᐜయ㛫࡛Ⓨ⌧㔞ࢆẚ㍑ࡋ㸪࢜ࣜࢦ࣐࣮ᙧᡂࡢྍ⬟ᛶࢆ᳨ウࡍࡿࡇ࡜࡛ⱞ࿡ཷᐜᶵ
ᵓゎ᫂ࡢ୍ຓ࡜ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ ඲㌟㸪ཱྀ⭍ෆࡀ೺ᖖ࡛ႚ↮Ṕࡢ࡞࠸20㹼30ṓ௦ࡢᡂே⏨ᛶ26ྡࢆ⿕㦂⪅࡜ࡋࡓ㸬⿕㦂⪅ࡢⴥ≧ங㢌㒊ࢆᩘᅇ᧿㐣ࡋ㸪⯉⾲ᒙ㒊ࡢ⤌⧊ࢆ᥇ྲྀ5)ࡋࡓ㸬᥇ྲྀࡋࡓ᳨య࠿ࡽtotal RNAࢆᢳฟࡋ㸪RT-qPCRἲ࡟ࡼࡾ೺ᖖ⪅࡟ẚ㍑ⓗ㧗⋡࡟ࡳࡽࢀࡿ㸵✀㢮ࡢⱞ࿡ ཷ ᐜ య 㑇 ఏ Ꮚ (TAS2R3 㸪 TAS2R8 㸪 TAS2R9 㸪
TAS2R13㸪TAS2R16㸪TAS2R43㸪TAS2R48) 5)࠾ࡼ
ࡧ 9 ✀ 㢮 ࡢ ࢟ ࢽ ࣮ ࢿ ཷ ᐜ య 㑇 ఏ Ꮚ (TAS2R4 㸪
TAS2R7 㸪 TAS2R10 㸪 TAS2R14 㸪 TAS2R31 㸪
TAS2R39㸪TAS2R40㸪TAS2R42㸪TAS2R46) 4)ࡢⓎ⌧㔞ࢆィ ࡋࡓ㸬ᚓࡽࢀࡓ⤖ᯝࡣE-actin㸦ACTB㸧࡟࡚⿵ṇࡋࡓ㸬ィ ࡋࡓࢹ࣮ࢱࡣᲠ᳨༷ᐃࢆ⾜࠸㸪୍ඖ㓄⨨ศᩓศᯒ࡜SNK᳨ᐃ࡟ࡼࡾ㑇ఏᏊⓎ⌧㔞ࢆẚ㍑ࡋࡓ㸬ࡲࡓ␗࡞ࡿ஧ࡘࡢ㑇ఏᏊ㛫࡟࠾ࡅࡿⓎ⌧㔞ࡢ┦㛵ࢆSpearman’s correlationࢆ⏝࠸࡚ㄪ࡭ࡓ㸬࡞࠾㸪ᮏ◊✲ࡣዟ⩚኱Ꮫ೔⌮ᑂᰝጤဨ఍࡟ࡼࡿᢎㄆ㸦ᢎㄆ
␒ྕ78㸧ࢆཷࡅᐇ᪋ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ⱞ࿡ཷᐜయ㑇ఏᏊࡢⓎ⌧㔞ࡣ✀㢮࡟ࡼࡗ࡚␗࡞ࡾ㸪TAS2R8ࡣⓎ⌧㔞ࡀ᭱ࡶከ࠿ࡗࡓ㸬ࡲࡓ㸪ྛཷᐜయ㛫࡟࠾ ࡅࡿ㑇ఏᏊⓎ ⌧㔞࡛ࡣ㸪TAS2R14࡜
TAS2R42ࡢ㛫࡟ᙉ࠸┦㛵ࢆ㸪TAS2R43࡜TAS2R3㸪
TAS2R9 㸪 TAS2R48 ࡢ 㛫 ࡟ ୰ ➼ ᗘ ࡢ ┦ 㛵 ࢆ 㸪
TAS2R31࡜TAS2R42࠾ࡼࡧTAS2R43࡜TAS2R16ࡢ㛫࡟ᙅ࠸┦㛵ࢆㄆࡵࡓ㸬ࡇࢀࡽࡢ⤌ࡳྜࢃࡏࡣ㸪ࡍ࡭࡚࣊ࢸ࣮࣐ࣟࢆᙧᡂࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ5)㸬ࡇࢀࡲ࡛ᙜㅮᗙ࡛ࡣ࢟ࢽ࣮ࢿཷᐜయⓎ⌧㔞㛫ࡢ┦㛵ࢆㄪ࡭㸪࢟ࢽ࣮ࢿࡢཷᐜᶵᵓ࡬ࡢ㛵㐃ᛶࢆሗ࿌ࡋ࡚ࡁࡓࡀ㸪௒ᅇࡢ⤖ᯝ࠿ࡽ࢟ࢽ࣮ࢿࡢཷᐜ
య௨እࡢཷᐜయ࡜ࡶ㸪࢜ࣜࢦ࣐࣮ࢆᙧᡂࡍࡿࡇ࡜
࡛స⏝ࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬≉࡟㸪TAS2R14
ࡣTAS2R42࡜ඹᙺࡋ࡚࠸ࡿྍ⬟ᛶࡀ㧗࠸࡜⪃࠼ࡽ
ࢀࡓ㸬
ϫ㸬 ᩥ⊩
1) 㤿ሙᅬᏊ㸬ⱞ࿡࡟㛵㐃ࡍࡿၚᾮ୰ࢱࣥࣃࢡ㉁ࡢ᳨ฟ㸬ዟ⩚኱ṑᏛㄅ2003㸹30㸸189-196 㸬2) ࿴⏣⿱୍㸬ၚᾮ୰Histatin 5ࡢ࢟ࢽ࣮ࢿཷᐜ࡟
ᑐࡍࡿຠᯝ㸬ዟ⩚኱ṑᏛㄅ2011㸹38㸸13-20㸬
3) ఀ⸨ 㞙㸪๓⏣㇏ಙ㸪ຍ⸨㟹ṇ㸪ᒣ᳃ᚭ㞝㸬ⱞ࿡ཷᐜᶵᵓ࡜hTAS2RsⓎ⌧㔞ࡢ㛵㐃㸬➨58ᅇዟ⩚኱ṑᏛ఍ࣉࣟࢢ࣒࣭ࣛண✏㞟2014㸸10㸬4) Kuhn C, Bufe B, Batram C and Meyerhof W.
Oligomerization of TAS2R bitter taste receptors.
Chem Senses 2010㸹35㸸395-406.
5) Onoda K, Hirai R, Takao K, Kokubun S, Ikeda M.
Patient with hypogeusia show changes in
expression of TAS2R taste receptor genes in their
tongues. Laryngoscope 2011㸹121㸸2592-2597.

− 175 −

第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2─3─9㢡㢦㠃➽ࡢᐇ㦂ⓗ཰⦰㐠ື࡟ᑐࡍࡿᢠ⑂ປᛶ
‫⏕ۑ‬㥖᭸Ꮚ㸪᭷㤿ኴ㑻*㸪ᒣཱྀὈᙪ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ཱྀ⭍ᶵ⬟Ꮫㅮᗙෙᶫ⩏ṑ⿵⥛Ꮫᩍᐊ*໭ᾏ㐨኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ᅜ㝿ṑ⛉㒊㛛
Anti-fatigue effect of experimental contraction in craniofacial muscle groups
Ikoma T, Arima T*, Yamaguchi T
Department of Crown and Bridge Prosthodontics, Graduate School of Dental Medicine, Hokkaido University*Division of International Affairs, Graduate School of Dental Medicine, Hokkaido UniversityϨ㸬 ┠ⓗ ࿪ᄮ➽ࡢ㐣⥭ᙇࡸ␗ᖖ㐠ື࡟≉ᚩ࡙ࡅࡽࢀࡓࣈ
ࣛ࢟ࢩࢬ࣒ࡣ㢡㛵⠇⑕ࡢཎᅉࡢ୍ࡘ࡜ࡋ࡚㛗ᖺ⪃࠼ࡽࢀ࡚ࡁࡓ㸬ࡋ࠿ࡋ᭱㏆ࡢ◊✲࡛㸪పᙉᗘ࡛࠿
ࡘ㛗᫬㛫࡟Ώࡿᐇ㦂ⓗᣢ⥆ⓗ࿪ᄮ➽཰⦰ࡀ㸪୍㐣ᛶࡢ࿪ᄮ➽③ࢆ㉳ࡇࡋࡓࡶࡢࡢ㢡㛵⠇⑕ᵝࡢ⑕≧ࡣㄏⓎࡋ࡞࠿ࡗࡓࡇ࡜ࡀሗ࿌ࡉࢀࡓ1)㸬ࡑࡇ࡛ᮏ◊✲ࡣ㸪㢡㢦㠃➽࡟ࡣᢠ⑂ປᛶࡀ࠶ࡾ㸪ࣈࣛ࢟ࢩࢬ
࣒ࡢࡼ࠺࡞㐣⥭ᙇࡸ␗ᖖ㐠ືࡢ➽άື࡛ࡣ㐠ືᚋ
⑊③ࡣㄏⓎࡉࢀ࡞࠸㸪࡜࠸࠺௬ㄝࡢࡶ࡜㸪ཱྀ㍯➽㸪
║㍯➽࡟ᐇ㦂ⓗᣢ⥆ⓗ➽㐠ືࢆࡉࡏ㸪➽③Ⓨ⏕ࡢ᭷↓ࢆ᳨ドࡋࡓ㸬ࡲࡓ➽⩌࡟ࡼࡿ➽⑂ປ㸪⑊③ࡢ
ᛶ㉁࡟ࡘ࠸࡚㸪McGill③ࡳࡢホ౯⚊ (McGill Pain
Questionnaire: MPQ)2)ࢆ⏝࠸࡚ㄪᰝࡋࡓ㸬ϩ㸬 ᪉ἲ ೺ᖖ⿕㦂⪅16ྡ(⏨ᛶ7ྡ: 25.7±1.4ṓ (ᖹᆒ±SD)㸪
ዪᛶ9ྡ: 24.9±2.3ṓ)ࡀ20㸣᭱኱㝶ព➽཰⦰ຊ࡛ࡢ
ᣢ⥆ⓗ➽཰⦰㐠ືࢆ㸪3➽⩌(㛢ཱྀ➽㸪ཱྀ㍯➽㸪║㍯➽)࡟࡚ࡑࢀࡒࢀ5ศ㛫6ᅇ⾜ࡗࡓ㸬ྛ➽⩌ࡢᐇ㦂ⓗ➽཰⦰㐠ືࡢᐇ᪋ࡣ1㐌㛫௨ୖࡢఇᜥᮇ㛫ࢆタࡅ㸪ᐇ᪋㡰ᗎࡣ↓సⅭ࡟Ỵᐃࡋࡓ㸬 ⿕㦂⪅ࡣ➽㐠ື๓㸪୰㸪ᚋࡢ⑊③㸪⑂ປ㸪୙ᛌឤ㸪ࢫࢺࣞࢫࡢᙉᗘࢆ11ẁ㝵(0-10)ᩘ್ホ౯ࢫࢣ࣮ࣝ(Numerical Rating Scale: NRS)ࢆ⏝࠸࡚ホ౯ࡋࡓ㸬ࡲࡓⓎ⌧ࡋࡓ⑊③ࡢᛶ㉁ࢆ㸪MPQࢆ⏝࠸࡚ホ౯ࡋ㸪⑊③㡿ᇦࡣ㢌⵹ཱྀ࣭⭍ᶍᘧᅗୖ࡟グධࡋ㸪⑊③㡿
ᇦ ࡢ ศ ᕸ ࢆ ㄪ ᰝ ࡋ ࡓ 㸬 ⤫ ィ ࡣ ANOVAs ࡜ Tukey
HSDࢸࢫࢺࢆ⏝࠸➽཰⦰㐠ື๓ࡢᏳ㟼᫬ࢆ࣮࣋ࢫ
ࣛ࢖ࣥ࡜ࡋ࡚ศᯒࡋ㸪P<0.05ࢆ᭷ព࡜ࡋࡓ㸬MPQ
ࡢ⑊③ࡢᛶ㉁ࡣ⿕㦂⪅ࡢ30%௨ୖࡀ㑅ᢥࡋࡓ⑊③ࢆࠕ᭱ࡶឤࡌࡽࢀࡓ⑊③ࡢᛶ㉁ࠖ࡜ࡋࡓ㸬 ࡞࠾ᮏᐇ㦂ࡣࡍ࡭࡚ࢹ࣐࣮ࣥࢡ㸪࣮࢜ࣇࢫ኱Ꮫ
࡟࡚ᐇ᪋ࡋ㸪ᐇ㦂ィ⏬᭩ࡣྠ◊✲ᶵ㛵ࡢ೔⌮ᑂᰝጤဨ఍ࡢᑂᰝ㸪ᢎㄆࢆཷࡅࡓᚋ࡟⾜ࡗࡓ㸬P<0.05)㸬㛢ཱྀ➽ࡣཱྀ㍯➽㸪║㍯➽࡜ẚ࡭࡚㧗࠸್ࢆ♧ࡋࡓࡀ(NRS: P<0.05)㸪ཱྀ㍯➽࡜║㍯➽㐠ື࡟ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ(NRS: P>0.063)㸬ࡋ࠿ࡋࡇࢀ
ࡽ⑊③ࡣࡍ࡭࡚㐠ື1᫬㛫ᚋ࡟ᾘኻࡋࡓ㸬⑊③ࡢᛶ㉁ࡣ㛢ཱྀ➽࡛㐠ື┤ᚋࡢࠕࡪࡿࡪࡿ㟈࠼ࡿࡼ࠺࡞ࠖ
࡜ࠕࡌࢃࡗ࡜ࡋࡓࠖ⑊③ࡀㄆࡵࡽࢀࡓࡀ1᫬㛫ᚋ࡟ࡣᾘኻࡋ㸪௦ࢃࡗ࡚ࠕᅽ㏕ࡉࢀࡿࡼ࠺࡞ࠖ⑊③ࡀㄆࡵࡽࢀࡓ㸬ཱྀ㍯➽࡛ࡣ⑊③ࡢᛶ㉁࡟≉ᚩࡣ↓ࡃ㸪
║㍯➽࡛ࡣ㐠ື┤ᚋ࡟ࠕᅽ㏕ࡉࢀࡿࡼ࠺࡞ࠖ࡜
ࠕ࠸ࡽ࠸ࡽࡉࡏࡿࠖ⑊③ࢆㄆࡵࡓ㸬⑊③㡿ᇦࡢศᕸࡣ㸪ྛ➽⩌ࡢ㡿ᇦ࡟㝈ᒁࡉࢀ࡚࠾ࡾ㸪3✀ࡢ➽⩌࡛ࡢ⑊③㡿ᇦࡢ୍⮴ࡣぢࡽࢀ࡞࠿ࡗࡓࡀ㸪ഃ㢌➽㸪๓㢌㒊㡿ᇦ࡟⑊③ࡀⓎ⌧ࡋࡓ⿕㦂⪅ࡀ࠸ࡓ(㛢ཱྀ➽㐠ື᫬:6ྡ㸪ཱྀ㍯➽:1ྡ㸪║㍯➽:5ྡ)㸬
 ᮏ◊✲࡟࠾ࡅࡿ㛢ཱྀ➽㸪ཱྀ㍯➽㸪║㍯➽⩌ࡢపᙉᗘ࡛ᣢ⥆ⓗ࡞➽཰⦰㐠ືࡣ㸪୍᫬ⓗ࡞⑕≧ࢆᘬࡁ㉳ࡇࡋࡓࡶࡢࡢ㸪≉ᚩⓗ࡞㐜Ⓨᛶ➽⫗③ࡣច㉳ࡋ࡞࠿ࡗࡓ㸬ࡇࢀࡣ㢡㢦㠃➽ࡢᢠ⑂ປᛶࢆ♧၀ࡋ࡚࠸ࡿ㸬ࡋ࠿ࡋ㛢ཱྀ➽࡛ࡣཱྀ㍯➽㸪║㍯➽ࡢ㐠ື᫬ࡼࡾࡶᙉ࠸⑕≧ࢆᘬࡁ㉳ࡇࡍࡇ࡜㸪⑊③ࡢᛶ㉁ࡀ␗࡞ࡗ࡚࠸ࡿࡇ࡜࠿ࡽ㸪㛢ཱྀ➽⩌ࡢ཰⦰㐠ື࡟ࡣ௚ࡢ㢡㢦㠃➽⩌࡜ẚ㍑ࡋ࡚ຊࡢⓎ⌧ࡸ⪏ஂࡢ㠃࡛␗࡞ࡗࡓᶵᵓࢆࡶࡘྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬 ௒ᚋࡣ㢡㛵⠇⑕ᝈ⪅ࡸ㢌③ᝈ⪅࡞࡝㸪ᐇ㝿ࡢᝈ⪅࡟࠾ࡅࡿ⑕≧ࡢ᳨ウ㸪೺ᖖ⪅࡜ࡢẚ㍑᳨ウࡀᚲ
せ࡜⪃࠼ࡽࢀࡿ㸬ϫ㸬 ᩥ⊩1) Takeuchi T, Arima T, Ernberg M, Yamaguchi T,
Ohata N, Svensson P. Symptoms andphysiological responses to prolonged, repeated,
low-level tooth clenching in human. J Head andFace Pain; in press.
2) Merzack R. The McGill pain questionnaire: major
properties and scoring methods. Pain 1975; 3:
277-299.

Ϫ㸬 ⤖ᯝ࡜⪃ᐹ 㛢ཱྀ➽㸪ཱྀ㍯➽㸪║㍯➽ࡢ࠸ࡎࢀࡶᐇ㦂ⓗ཰⦰㐠ື㛤ጞᚋ࠿ࡽ⑊③㸪⑂ປ㸪୙ᛌឤ㸪ࢫࢺࣞࢫࡀ
Ⓨ⌧ࡋ㸪ホ౯ᩘ್ࡣ᫬㛫࡜࡜ࡶ࡟ୖ᪼ࡋࡓ(NRS:− 176 −

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 10ཱྀ⭍⢓⭷࠾ࡼࡧ㢦㠃⓶⭵ࡢษ㛤ᚋ⑊③࡟ᑐࡍࡿTRPࢳࣕࢿࣝࡢ㛵୚‫ۑ‬ᾆ⏣೺ኴ㑻㸪すᑿ೺௓㸪ఀ⸨⋹ኸ㸪୸㔝඘㸪ᩪ⸨ᘯே㸪ᮤ῟㸪ఀ⸨ᬛຍ㸪⽷ᅬⓑಙோ᪥ᮏ኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨Ϩㅮᗙ
Involvement of TRP channels in incisional oral mucosa and facial skin pain

Urata K㸪Nishio K㸪Ito R㸪Maruno M㸪Saito H㸪Lee J㸪Ito T㸪Gionhaku N
Department of Complete Denture Prosthodontics Nihon University School of DentistryϨ㸬 ┠ⓗ ⿵⥛⮫ᗋ࡟࠾࠸࡚㸪ཱྀ⭍⢓⭷࡟᫂ࡽ࠿࡞₽⒆ࡀ
ᙧᡂࡉࢀ࡚࠸ࡿ࡟ࡶ㛵ࢃࡽࡎᙉ࠸⑊③ࢆッ࠼ࡿࡇ࡜࡞ࡃ⩏ṑࢆ౑⏝ࡋ࡚࠸ࡿᝈ⪅࡟㐼㐝ࡍࡿࡇ࡜ࡀ
࠶ࡿ㸬ࡇࡢࡼ࠺࡟ཱྀ⭍⢓⭷ឤぬࡢ⑊③ឤཷᛶࡣཱྀ
⭍እ࡜ẚ㍑ࡋ࡚኱ࡁࡃ␗࡞ࡿ஦ࡀ⪃࠼ࡽࢀࡿࡀ㸪ཱྀ⭍ෆእ࡟࠾ࡅࡿእയᚋࡢ⑊③Ⓨ⑕ᶵᵓࡢ㐪࠸࡟ࡘ࠸࡚ࡣ࠸ࡲࡔ᫂ࡽ࠿࡛ࡣ࡞࠸㸬౵ᐖཷᐜయ࡜ࡋ࡚ ࡣ 㸪 Transient receptor potential vanilloid 1
(TRPV1)TRPV2ࡢⓎ⌧ࡀ㛵୚ࡋ࡚࠾ࡾ 1) 㸪TRPV1
࡜TRP ankyrin1(TRPA1)ࡢ┦஫స⏝ࡣᮎᲈࡢ౵ᐖཷ
ᐜࢆㄪ⠇ࡋ㸪ࡉࡽ࡟㸪ཱྀ⭍ෆࡢ㒊఩࡟ࡼࡗ࡚TRPࢳࣕࢿࣝࡢⓎ⌧ࡀ኱ࡁࡃ␗࡞ࡿࡇ࡜ࡶሗ࿌ࡉࢀ࡚
࠸ࡿ 2) ࡇ࡜࠿ࡽ㸪TRPV1㸪TRPV2㸪TRPA1ࡀཱྀ⭍ෆእࡢᦆയ࡟ࡼࡿ⑊③ឤཷᛶࡢ㐪࠸࡟㛵୚ࡋ࡚࠸ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡿ㸬ᮏ◊✲࡛ࡣS.D⣔㞝ᛶࣛࢵࢺࢆ⏝࠸㸪⤌⧊ษ㛤࡟ࡼࡾⓎ⑕ࡍࡿཱྀ⭍ෆእࡢእയ
ᚋ③ぬ㐣ᩄ࡟࠾ࡅࡿTRPV1㸪TRPA1࠾ࡼࡧTRPV2ࡢ㛵୚ࡢゎ᫂ࢆ┠ⓗ࡜ࡋࡓϩ㸬 ᪉ἲ ษ㛤ᛶእയࣔࢹࣝࡢసᡂ࡜⾜ືほᐹᐇ㦂 S.D⣔㞝ᛶࣛࢵࢺࡢ9㐌㱋ࢆ⏝࠸㸪඲㌟㯞㓉ୗ࡟࠾࠸࡚ࣛࢵࢺࡢ㢋⢓⭷ࡲࡓࡣཱྀ㧨㒊⓶⭵࡟ษ㛤㸦㛗ࡉ : 10mm, ῝ࡉ : 5mm㸧ࢆຍ࠼ࡓ㸬ษ㛤ᚋ㸪ᗘ่⃭⏝ࣉ࣮ࣟࣈ࠾ࡼࡧࢹࢪࢱࣝࣇ࢛ࣥࣇࣛ࢖
ࢆ⏝࠸ཱྀ⭍ෆእࡢ⇕㸪෭่⃭࠾ࡼࡧᶵᲔ่⃭࡟ᑐ
ࡍࡿ㏨㑊㜈್ HWT ࢆ⤒᪥ⓗ࡟ィ ࡋࡓ㸦ᅗ㸧㸬 ษ㛤ᚋࡢ୕ཫ⚄⤒⠇⣽⬊ (TG⣽⬊)࡟࠾ࡅࡿTRPࢳࣕࢿࣝࡢච␿⤌⧊໬Ꮫゎᯒ ࠶ࡽ࠿ࡌࡵ⚄⤒㏫⾜ᛶⰍ⣲ DiI࠶ࡿ࠸ࡣFG ࢆ㢋⢓⭷ࡲࡓࡣཱྀ㧨㒊ୖ⓶࡟ᢞ୚ࡋ㸪ษ㛤ᚋ᪥┠࡟୕ཫ⚄⤒⠇ࢆ᦬ฟࡋ㸪TRPV1TRPV2,TRPA1ࡢษ㛤ᚋࡢⓎ⌧ኚ໬ࢆゎᯒࡋࡓ㸬 TRPࢳࣕࢿࣝᣕᢠ⸆ᢞ୚࡟ࡼࡿ⾜ື⸆⌮Ꮫゎᯒ ษ㛤ᚋ㸪SB366791,HC030031ࡲࡓࡣTranilastࢆᢞ୚ࡋ㸪ᢞ୚ᚋࡢ㢋⢓⭷࠾ࡼࡧཱྀ㧨㒊⓶⭵ࡢ ⇕࠾ࡼࡧᶵᲔ่⃭࡟ᑐࡍࡿ㏨㑊㜈್ࢆ⤒᫬ⓗ࡟ィ ࡋ③ぬ㐣ᩄ࡬ࡢྛTRPࢳࣕࢿࣝࡢ㛵୚ࢆ᳨ウࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ 㢋⢓⭷ࡀᦆയࡉࢀࡿ࡜ษ㛤㒊ࢆᨭ㓄ࡍࡿTG⣽⬊
࡟࠾࠸࡚TRPV1㸪TRPV2࠾ࡼࡧTRPA1ࡢⓎ⌧ࡀቑຍࡋ㸪≉࡟TRPV1࡜TRPA1࡟㛵ࡋ࡚ࡣ㸪TRPV1࠶
ࡿ࠸ࡣTRPA1ࡀ༢⊂࡛ቑຍࡋ࡚⇕㸪ᶵᲔ࠾ࡼࡧ෭
③ぬ㐣ᩄࡀⓎ⑕ࡍࡿ㸬୍᪉㸪ཱྀ㧨㒊⓶⭵ࡀᦆയࡉࢀࡿ࡜㸪ษ㛤㒊ࢆᨭ㓄ࡍࡿTG⣽⬊࡟࠾࠸࡚TRPV1㸪
TRPV2࠾ࡼࡧTRPA1ࡢⓎ⌧ࡀቑຍࡋ㸪≉࡟TRPV1
࡜TRPA1࡟㛵ࡋ࡚ࡣ㸪TRPV1࡜TRPA1ࡢඹⓎ⌧ࡀቑຍࡋ㸪⇕㸪ᶵᲔ࠾ࡼࡧ෭③ぬ㐣ᩄࡀⓎ⑕ࡍࡿ㸬TRPV2ࡣ㢋⢓⭷࠾ࡼࡧཱྀ㧨㒊⓶⭵ᦆയᚋ㸪TG⣽⬊
࡟࠾࠸࡚᭷ព࡟Ⓨ⌧ࡀቑຍࡋࡓࡇ࡜࠿ࡽ㸪୧㒊఩ࡢᦆയ࡟ࡼࡗ࡚ᘬࡁ㉳ࡇࡉࢀࡿ⇕࠾ࡼࡧᶵᲔ③ぬ㐣ᩄ࡟ࡣTRPV2ࡀ㛵୚ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓ㸬ษ㛤㒊ࡢ఩⨨࡜⾜ືほᐹᐇ㦂ࡢ่⃭᪉ἲϫ㸬 ᩥ⊩1) Banik RK, Brennan TJ. Trpv1 mediates
spontaneous firing and heat sensitization of
cutaneous primary afferents after plantar incision.
Pain 2009 ; 141 : 41-51.
2) Wang B, Danjo A, Kajiya H, Okabe K, Kido MA.
Oral epithelial cells are activated via TRP
channels. J.Dent Res 2011 ; 90 (2) : 163-172.

− 177 −

第2日

第 3 会場

日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 11╧╀࣭ぬ㓰≧ែ࠾ࡼࡧ㌟యάື㔞ࡀ㢡ࡢ៏ᛶ③࡟ཬࡰࡍᙳ㡪‫ۑ‬Ᏹ㔝ᾈ୍㑻㸪▼ᇉᑦ୍㸪᪂㇂ Ṍ*㸪▮㇂༤ᩥ኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉㢡ཱྀ⭍ᶵ⬟෌ᘓᏛㅮᗙࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫศ㔝*኱㜰኱Ꮫ኱Ꮫ㝔་Ꮫ⣔◊✲⛉⮫ᗋ⤫ィ␿Ꮫᐤ㝃ㅮᗙ
Effect of Sleep-Wake State and Physical Activity on Chronic Jaw Pain
Uno K, Ishigaki S, Shintani A*, Yatani H
Osaka University Graduate School of Dentistry, Department of Fixed Prosthodontics*Osaka University Graduate School of Medicine, Department of Clinical Epidemiology and BiostatisticsϨ㸬 ┠ⓗ Yunus1) ࡟ ࡼ ࡾ ᥦ ၐ ࡉ ࢀ ࡓ central sensitization
syndromeࡣ㸪୰ᯡᛶ㐣ᩄࢆཎᅉ࡜ࡋ࡚Ⓨ⑕ࡍࡿ࡜᥎ ࡉࢀࡿ⑌ᝈ⩌ࢆ⾲ࡋ㸪἞⒪࡟཯ᛂࡋ࡟ࡃ࠸៏
ᛶࡢ࿪ᄮ➽③ࡶࡇࡢ⑌ᝈᴫᛕ࡟ໟྵࡉࢀࡿ࡜⪃࠼ࡽࢀࡿ㸬ᚑ᮶㸪③ࡳࡀ╧╀ࡢ㉁ࢆపୗࡉࡏࡿ࡜⪃࠼ࡽࢀ࡚ࡁࡓࡀ㸪⌧ᅾ࡛ࡣ╧╀㞀ᐖࡀ⑊③㜈್ࢆపୗࡉࡏ㸪⑊③ࡢ៏ᛶ໬ࡸ㔜⠜໬ࢆᣍࡃ࡜࠸࠺௬
ㄝࡶᨭᣢࡉࢀ࡚࠸ࡿ2)㸬ᮏ◊✲ࡢ┠ⓗࡣ╧╀࣭ぬ㓰≧ែ࠾ࡼࡧ᪥୰ࡢ㌟యάື≧ែࡀ࿪ᄮ➽ࡢ៏ᛶ③࡟ཬࡰࡍᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡛࠶ࡿ㸬ϩ㸬 ᪉ἲ⿕㦂⪅࡜ࡋ࡚㸪2013ᖺ10᭶࠿ࡽ2014ᖺ11᭶ࡢ㛫࡟㸪◊✲ࡢᴫせࢆㄝ᫂ࡋᩥ᭩࡟ࡼࡿྠពࡀᚓࡽࢀ
ࡓዪᛶ15ྡࢆ㑅ᢥࡋࡓ㸦ᖹᆒᖺ㱋38.8 ± 10.1ṓ㸧㸬㝖እᇶ‽ࡣ㸸1㸧㐃⥆ࡋ࡚⿦⨨ࡢ⿦╔ࡀᅔ㞴࡛࠶ࡿࡶࡢ㸹2㸧῝ኪ஺௦໅ົࡢ࠶ࡿ௙஦࡟ᚑ஦ࡋ࡚࠸ࡿ
ࡶࡢ㸹3㸧⢭⚄⑌ᝈࡢ἞⒪୰࡛࠶ࡿࡶࡢ㸹4㸧ዷፎࡶࡋࡃࡣዷፎࡢྍ⬟ᛶࡢ࠶ࡿࡶࡢ࡜ࡋࡓ㸬15ྡࡢ
࠺ࡕ8ྡࡣ࿪ᄮ➽࡟៏ᛶ③ࢆ᭷ࡋ㸪㢡㛵⠇⑕࡜デ᩿ࡉࢀࡓ㸬௚ࡢ7ྡ࡟ࡘ࠸࡚ࡣ㸪③ࡳࡢッ࠼ࡀࡲࡗࡓ
ࡃ࡞࠸ࡇ࡜㸪ゐデ࡟ࡼࡿ࿪ᄮ➽ࡢ⑊③ࡀ࡞࠸ࡇ࡜
ࢆ☜ㄆࡋࡓ㸬╧╀≧ែ㸪㌟యάື≧ែࡢ ᐃ࡟ࡣ
Micro Motionlogger Actigraph㸦A.M.I.♫㸧ࢆ౑⏝ࡋࡓ㸬ศᯒ࡟ࡣ⥲╧╀᫬㛫࠾ࡼࡧ᪥୰ࡢ㌟యάືᩘࡢ୰ኸ್ࢆ౑⏝ࡋࡓ㸬๓ኪࡢ⇍╧ᗘ࠾ࡼࡧ㢡ࡢ③
ࡳࡢ ᐃ࡟ࡣVisual Analogue Scale 㸦VAS㸧ࢆ౑⏝ࡋࡓ㸬㢡ࡢ③ࡳࡣ㉳ᗋ᫬ࡼࡾ3᫬㛫ẖ࡟VAS࡟グධࡉࡏࡓ㸬ศᯒ࡟ࡣ㉳ᗋᚋ6᫬㛫ෆࡢ㢡ࡢ③ࡳࡢ᭱኱್㸦Jaw Pain FP㸧࡜㸪㉳ᗋᚋ6᫬㛫௨㝆ࡢ㢡ࡢ③ࡳࡢ᭱኱್㸦Jaw Pain SP㸧ࢆ౑⏝ࡋࡓ㸬๓ኪࡢ⇍╧ᗘࡣ㉳ᗋ᫬࡟VAS࡟グධࡉࡏࡓ㸬⤫ィゎᯒ࡟ࡣ
IBM SPSS Statistics ver. 22.0ࢆ౑⏝ࡋࡓ㸬ศᯒ࡟ࡣΰྜຠᯝࣔࢹࣝࢆ⏝࠸ࡓ㸬ᮏ◊✲࡛ࡣᚑᒓኚᩘࢆ㸪㉳ᗋᚋ6᫬㛫ෆࡢ㢡ࡢ③ࡳࡢ᭱኱್㸪࠾ࡼࡧ㉳ᗋᚋ6᫬㛫௨㝆ࡢ㢡ࡢ③ࡳࡢ᭱኱್࡜ࡋ㸪ඹኚ㔞ࢆ㸪๓ኪࡢ⥲╧╀᫬㛫㸪๓ኪࡢ⇍╧ᗘ㸪๓᪥ࡢ㌟యάື㔞㸪๓᪥ࡢ㉳ᗋᚋ6᫬㛫ෆࡢ㢡ࡢ③ࡳࡢ᭱኱್㸪๓᪥ࡢ㉳ᗋᚋ6᫬㛫௨㝆ࡢ㢡ࡢ③ࡳࡢ᭱኱್࡜ࡋࡓ㸬ᚑᒓኚᩘ࡟ᑐࡋ࡚᫬⣔ิⓗ࡟▩┪ࡢ⏕ࡌࡿඹኚ㔞ࡣ㝖እࡋࡓ㸬᭷ពỈ‽ࡣࡍ࡭࡚5㸣࡜ࡋ㸪ศᕸࡢṇつ໬ࢆ⾜࠺ࡓࡵ࡟ࡍ࡭࡚ࡢᚑᒓኚᩘ
ࡣᑐᩘኚ᥮ࢆ⾜ࡗࡓ㸬⏕⌮ᮇ㛫୰࡛࠶ࡿ࠿࡝࠺࠿㸪ᖺ㱋࠾ࡼࡧ㢡㛵⠇⑕ࡢ᭷↓࡟ࡘ࠸࡚ࡣ⿵ṇࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ๓᪥ࡢ⇍╧ᗘࡣJaw Pain FP㸪Jaw Pain SP࡟᭷ព࡟ᙳ㡪ࡋ࡚࠸ࡓ㸬๓᪥ࡢ㌟యάື㔞ࡶJaw Pain FP㸪
Jaw Pain SP࡟᭷ព࡟ᙳ㡪ࡋ࡚࠸ࡓ㸬๓᪥ࡢJaw Pain
FP࠾ࡼࡧ๓᪥ࡢJaw Pain SPࡣJaw Pain FP࡟᭷ព࡟ᙳ㡪ࡋ࡚࠸ࡓ㸦⾲㸧㸬ࡍ࡞ࢃࡕ㸪๓᪥ࡢ⇍╧ᗘࡀప࠸࡜㸪࠶ࡿ࠸ࡣ๓᪥ࡢ㌟యάື㔞ࡀᑡ࡞࠸࡜㸪࠶ࡿ࠸ࡣ๓᪥ࡢ㢡ࡢ③ࡳࡀᙉ࠸࡜㢡ࡢ③ࡳࡀᙉࡃ࡞ࡿࡇ࡜ࡀ♧ࡉࢀࡓ㸬௨ୖࡢࡼ࠺࡟╧╀࠾ࡼࡧ㌟యάື㔞ࡣ࿪ᄮ➽ࡢ
៏ᛶ③ࡢ⛬ᗘ࡟ᐦ᥋࡟㛵ಀࡋ࡚࠾ࡾ㸪ಶయᕪ἞⒪ࢆ㐍ࡵࡿୖ࡛╧╀≧ែ࠾ࡼࡧ㌟యάື≧ែࢆホ౯ࡍࡿࡇ࡜ࡢ᭷⏝ᛶࡀ♧ࡉࢀࡓ㸬ΰྜຠᯝࣔࢹࣝ࡟ࡼࡿศᯒ⤖ᯝ



ඹኚ㔞
๓ኪࡢ⥲╧╀᫬㛫๓ኪࡢ⇍╧ᗘ
๓᪥ࡢ㌟యάືᩘ
๓᪥ࡢ
๓᪥ࡢ

!""
#
$$$
$$
$$/
++$
++7

ᚑᒓኚᩘ
!""  $%㸣&'
$%㸣&'
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್
್ ୗ㝈
ୗ㝈
ୖ㝈
ୖ㝈
 % *++ / +++4 $$$ 4+ *++ / +++
+++ *+ 7 *++% $$4 +++ *+ +% *++4
+% *++%  *++++ $$/ +4 *++%4 *++++  ++  + /+ ++4 4% *++4 + %+ +++ + 4  ++  4 *++ 7 + ϫ㸬 ᩥ⊩1㸧Yunus MB. Role of central sensitization in symptoms
beyond muscle pain, and the evaluation of a patientwith widespread pain. Clin Rheumatol 2007; 21:481-497.
2㸧Lunde L-H, Pallesen S, Krangnes L, Nordhus IH.
Characteristics of sleep in older persons with chronic
pain a study based on actigraphy and self-reporting.
Clin J Pain 2010; 26: 132-137.

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日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 12ࢩࢱࣟࣉ࣒ࣛࡀ࣐࢘ࢫည➽࠾ࡼࡧ㢕➽➽άື࡟ཬࡰࡍᙳ㡪 ‫ۑ‬㔝ᕝὈⴥ㸪ᮃ᭶ᩥᏊ*㸪∦ᒣ៞♸**㸪ụ⏣⨾⳯Ꮚ**㸪Ᏻ㒊཭ె**㸪 ຍ⸨㝯ྐ***㸪㤿ሙ୍⨾**㸪 ⱝᯘ๎ᖾ㸪 ஭ୖᐩ㞝*ᮾி་⛉ṑ⛉኱Ꮫ኱Ꮫ㝔་ṑᏛ⥲ྜ◊✲⛉㒊ศᗋ⩏ṑ⿵⥛Ꮫศ㔝㸪 ᫛࿴኱ᏛṑᏛ㒊ཱྀ⭍ ⏕⌮Ꮫㅮᗙ㸪 ᫛࿴኱Ꮫṑ⛉⿵⥛Ꮫㅮᗙ㸪኱㜰኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ཱྀ⭍ゎ๗➨஧ᩍᐊInfluence of Citalopram on neck and masseter muscle activities in mice
Nogawa Y, Mochizuki A*, Katayama K**, Ikeda M**, Abe Y**, Kato T***, Baba K**, Wakabayashi N,
Inoue T*
Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Removable Partial
Prosthodontics, *School of Dentistry, Showa University, Departments of Oral Physiology, **School of
Dentistry, Showa University, Departments of Prosthodontic, ***Graduate School of Dentistry, Osaka
University Department of Oral Anatomy and NeurobiologyϨ㸬 ┠ⓗ ࣈࣛ࢟ࢩࢬ࣒ࡣ㸪╧╀୰ࡢࢢࣛ࢖ࣥࢹ࢕ࣥࢢࡸ
ࢡࣞࣥࢳࣥࢢ࡟≉ᚩ௜ࡅࡽࢀࡿ࿪ᄮ➽άືࢆ୺య
࡜ࡋࡓ㠀ᶵ⬟ⓗ࡞㐠ື࡛1, 2)㸪ࡑࡢຊᏛⓗせ⣲ࡣṑࡸ㢡㛵⠇࡟㔜⠜࡞㞀ᐖࢆᘬࡁ㉳ࡇࡍྍ⬟ᛶࡀ࠶ࡿ㸬ࡇࢀࡲ࡛࡟㸪ࣄࢺ࡛ࡣᢠ࠺ࡘ⸆࡛࠶ࡿࢩࢱࣟࣉࣛ
࣒㸦SSRI㸪㑅ᢥⓗࢭࣟࢺࢽࣥ෌ྲྀࡾ㎸ࡳ㜼ᐖ⸆㸧ࢆ㛗ᮇ㛫᭹⏝ࡍࡿࡇ࡜࡛ࣈࣛ࢟ࢩࢬ࣒ࡀⓎ⑕ࡋࡓ࡜ࡢሗ࿌ࡀ࠶ࡿࡀ3)㸪ࡑࡢ࣓࢝ࢽࢬ࣒ࡣᮍࡔ୙᫂࡞
Ⅼࡀከ࠸㸬ࡑࡇ࡛ᡃࠎࡣ࣐࢘ࢫࢆ⏝࠸㸪ࢩࢱࣟࣉ࣒ࣛᢞ୚࡟ࡼࡗ࡚ྛ╧╀ࢫࢸ࣮ࢪ࡟࠾ࡅࡿည➽࠾ࡼࡧ㢕➽ࡢάື㔞ࡀ࡝ࡢࡼ࠺࡞ኚ໬ࡍࡿࡢ࠿ࢆ᳨
ウࡋࡓ㸬
ϩ㸬 ᪉ἲ
 ᐇ㦂࡟ࡣ7ࠥ10㐌㱋ࡢ㞝ᛶC57BL/6⣔⤫ࡢ࣐࢘ࢫࢆ7༉⏝࠸ࡓ㸬࣐࢘ࢫࡣಶูࢣ࣮ࢪ࡟ධࢀ㸪12᫬㛫ࡢ᫂ᬯࢧ࢖ࢡࣝ㸦Ⅼⅉࠝ᫂ᮇࠞ㸸༗๓8᫬㹼༗ᚋ8᫬㸪ᾘⅉࠝᬯᮇࠞ㸸༗ᚋ8᫬㹼༗๓8᫬㸧ࡢ⎔ቃୗ࡛㣫⫱ࡋࡓ㸬㯞㓉ୗ࡟࡚⏕య㟁Ẽಙྕ㸦⬻Ἴ㸪║㟁ᅗ㸪㢕➽࠾ࡼࡧည➽➽㟁ᅗ㸧グ㘓⏝ࡢ㟁ᴟ␃⨨ᡭ⾡ࢆ⾜ࡗࡓ㸬5᪥㛫ࡢᅇ᚟ᮇ㛫ࡢᚋ㸪グ㘓⏝ࢣ࣮ࣈࣝࡢࡳࢆ㢌㡬㒊ࡢࢥࢿࢡࢱ࡟⿦╔ࡍࡿࢺ࣮ࣞࢽ
ࣥࢢࢆ1᪥࠾ࡁ࡟3ᅇ⾜࠸㸪㥆໬ࡋࡓ㸬1᪥ࡢఇ᠁ᮇ
㛫ᚋ㸪ࢥࣥࢺ࣮ࣟࣝ࡜ࡋ࡚ୖグࡢ⏕య㟁Ẽಙྕࢆ24᫬㛫グ㘓ࡋࡓ㸬グ㘓⤊஢ᚋ㸪⏕⌮㣗ሷỈ㸦⏕㣗㸧࠶ࡿ࠸ࡣࢩࢱࣟࣉ࣒ࣛࢆ඘ሸࡋࡓᾐ㏱ᅽ࣏ࣥࣉ
㸦ALZET♫〇㸪#2002㸧ࢆ࣐࢘ࢫࡢ⫼㒊⓶ୗ࡟ᇙධࡋ 㸪 ⏕ 㣗 㸦 n = 3 㸧 ࠶ ࡿ࠸ࡣ ࢩ ࢱ ࣟ ࣉ ࣒ࣛ 㸦 10
mg/kg/day㸪n = 4㸧ࢆᣢ⥆ⓗ࡟ᢞ୚ࡋࡓ㸬ᾐ㏱ᅽ࣏
ࣥࣉᇙධᚋ1㸪3㸪5᪥┠࡟ୖグࡢ⏕య㟁Ẽಙྕࢆ24᫬㛫グ㘓ࡋ㸪5᪥┠ࡢࢹ࣮ࢱࢆゎᯒ࡟⏝࠸ࡓ㸬ᚓࡽࢀࡓࢹ࣮ࢱ࡟࠾࠸࡚㸪᣺ᖜࡢᑠࡉ࠸⬻Ἴ࡜㸪άືࡢ኱ࡁ࠸║㟁ᅗ࡜㢕➽➽㟁ᅗࡀㄆࡵࡽࢀࡿ࡜ࡇࢁ
ࡣぬ㓰᫬㸪᣺ᖜࡢ኱ࡁ࠸⬻Ἴ࡜㸪άືࡢᑠࡉ࠸║㟁ᅗ࡜㢕➽➽㟁ᅗࡀㄆࡵࡽࢀࡿ࡜ࡇࢁࡣࣀ࣒ࣥࣞ

╧╀㸪᣺ᖜࡢᑠࡉ࠸⬻Ἴ࡜㸪ࣀ࣒ࣥࣞ╧╀ࡼࡾࡉࡽ࡟పୗࡍࡿ㢕➽➽㟁ᅗࡀㄆࡵࡽࢀࡓ࡜ࡇࢁࡣࣞ
࣒╧╀࡜ุᐃࡋ㸪24᫬㛫ࡢグ㘓ࢆぬ㓰㸪ࣀ࣒ࣥࣞ╧╀㸪࣒ࣞ╧╀ࡢྛࢫࢸ࣮ࢪ࡟ศ㢮ࡋࡓ㸬ည➽࠾ࡼࡧ㢕➽ࡢ➽άືࡣ10⛊࢚࣏ࢵࢡẖࡢ✚ศ್ࢆồࡵ㸪ࢥࣥࢺ࣮ࣟࣝࡢぬ㓰᫬ࡢᖹᆒ್ࢆ100㸣࡜ࡋ࡚ṇつ໬ࡋホ౯ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ య㔜ࡢኚ໬࡟ࡘ࠸࡚ࡣ㸪ࢩࢱࣟࣉ࣒ࣛᢞ୚⩌࡜⏕㣗ᢞ୚⩌ࡢ࠸ࡎࢀࡶయ㔜ῶᑡࡣ᫂☜࡞ᕪࡣㄆࡵ
ࡽࢀ࡞࠿ࡗࡓ㸬➽άື࡟ࡘ࠸࡚ࡣ㸪ࢩࢱࣟࣉ࣒ࣛ
ᢞ୚⩌ࡣ⏕㣗ᢞ୚⩌࡟ẚ࡭࡚㸪ぬ㓰᫬ࡢည➽άືࡀᬯᮇ࡜᫂ᮇࡢ࠸ࡎࢀ࡟࠾࠸࡚ࡶቑ኱ࡍࡿഴྥࡀ
ㄆࡵࡽࢀࡓ㸬ࡲࡓ㸪ᬯᮇࡢࣀ࣒ࣥࣞ╧╀᫬࡛ࡶࢩࢱࣟࣉ࣒ࣛᢞ୚⩌ࡣ⏕㣗ᢞ୚⩌࡟ẚ࡭࡚ည➽άືࡀୖ᪼ࡍࡿഴྥࡀㄆࡵࡽࢀࡓ㸬୍᪉㸪㢕➽άື࡟ࡘ࠸࡚ࡣ㸪ࢩࢱࣟࣉ࣒ࣛᢞ୚⩌࡜⏕㣗ᢞ୚⩌ࡢ㛫࡛᫂☜࡞ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬௨ୖࡢ⤖ᯝࡼࡾ㸪࣐࢘ࢫ࡟ࢩࢱࣟࣉ࣒ࣛࢆᣢ⥆ⓗ࡟ᢞ୚ࡍࡿࡇ࡜࡟ࡼࡗ࡚㸪ည➽άືࡀୖ᪼ࡍࡿ
ྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) Kato T, Yamaguchi T, Okura K et al. Sleep lessand bite more: sleep disorders associated withocclusal loads during sleep. J Prosthodont Res.
2013; 57(2): 69-81.
2) Lavigne GJ, Khoury S, Abe S et al. Bruxism
physiology and pathology: an overview forclinicians. J Oral Rehabil. 2008; 35(7): 476-94.
3) Wise M. Citalopram-induced bruxism. Br J

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Psychiatry. 2001; 178:182.

第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 13

ཱྀ⵹ࡢ⿕そࡀࣄࢺ⬻ෆࡢ࿡ぬᛂ⟅࡟ཬࡰࡍᙳ㡪
̿7T-fMRI࡟ࡼࡿ⬻άືࡢᐈほⓗホ౯̿‫ஂۑ‬ಖ⏣ᑗྐ㸪ᑠᯘ⌶ஓ㸪Ḉᗞᾈஅ㸪⃝⏣ឡ㸪బࠎᮌ೺㸪㏆⸨ᑦ▱ᒾᡭ་⛉኱ᏛṑᏛ㒊⿵⥛࣭࢖ࣥࣉࣛࣥࢺᏛㅮᗙ
Effect of tasteresponse on human brain by the palate covering.
- Objective evaluation of brain activty using 7.0 tesla functional MRIKubota M, Kobayashi T, Sakuraba H, Sawada A, Sasaki K, Kondo H
Department of Prosthodontics and Oral Implantology, School of Dentistry, Iwate Medical UniversityϨ㸬 ┠ⓗ 㧗㱋⪅ேཱྀࡢቑຍ࡟క࠸㸪࿡ぬ㞀ᐖᝈ⪅ࡀቑຍࡋ࡚࠸ࡿ㸬࿡ぬ㞀ᐖࡢ⑓ែ࡜ཎᅉࡣከᒱ࡟ࢃࡓࡾ㸪ṑ⛉㡿ᇦ࡛ࡣཱྀ⵹ࢆ⿕そࡍࡿᗋ⩏ṑࢆ⿦╔ࡋࡓᝈ⪅ࡀࡋࡤࡋࡤ࿡ぬ㞀ᐖࢆッ࠼ࡿࡇ࡜ࡀ࠶ࡿ㸬ࡇࢀࡲ࡛㸪⩏ṑ⿦╔࡟క࠸㸪࿡ぬ㜈್ࡀୖ᪼ࡍࡿ࡜ࡢ
ሗ࿌ࡸ㸪⩏ṑ⿦╔᫬ࡢ࿡ぬㄆ㆑ࡲ࡛ࡢ᫬㛫࠿ࡽ㸪⩏ṑ⿦╔ࡣ࿡ぬᛂ⟅࡟ᙳ㡪ࡋ࡞࠸ࡇ࡜ࡢሗ࿌ࡶ࠶ࡾぢゎࡣ୍⮴ࡋ࡚࠾ࡽࡎ㸪⩏ṑ⿦╔࡜࿡ぬᛂ⟅ࡢ㛵㐃ᛶࡣᮍࡔ᫂ࡽ࠿࡟ࡉࢀ࡚࠸࡞࠸㸬㏆ᖺ㸪ཱྀ⭍㡿ᇦࡢᶵ⬟࣭ឤぬホ౯࡟㸪ୖ఩୰ᯡࡼࡾᐈほⓗホ౯ࡀྍ⬟࡞㠀౵くⓗ⬻࣐ࢵࣆࣥࢢἲࡢ1ࡘ࡛࠶ࡿ
fMRIࡀ⏝࠸ࡽࢀ࡚࠸ࡿ1㸧㸬࿡ぬ◊✲ࡢ㡿ᇦ࡛ࡣ㸪⬻ᶵ⬟࣐ࢵࣆࣥࢢ࡟ࡼࡿ࿡ぬ㔝ࡢྠᐃࡀ⾜ࢃࢀ࡚ࡁࡓࡀ㸪⿵⥛ṑ⛉Ꮫ࡜ࡢ㛵㐃㡿ᇦ࡛ࡢ᳨ウ࡟ࡘ࠸࡚ࡣᮍࡔሗ࿌ࡀ࡞࠸㸬ࡑࡇ࡛㸪ᮏ◊✲࡛ࡣ⩏ṑ࡟ࡼࡿཱྀ⵹⿕そࡀ࿡ぬᛂ⟅࡟ཬࡰࡍᙳ㡪࡟ࡘ࠸᳨࡚ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋ㸪⩏ṑ⿦╔࡟ࡼࡿ࿡ぬᛂ⟅ࡢኚ໬ࢆ㸪fMRIࢆ⏝࠸࡚⬻ࡢ㈿ά㡿ᇦࡢほⅬ࠿ࡽẚ㍑᳨ウࡋࡓ㸬ϩ㸬 ᪉ἲ ᮏ◊✲ࡣ㸪ᒾᡭ་⛉኱ᏛṑᏛ㒊೔⌮ጤဨ఍㸦ᢎㄆ␒ྕ㸸01197㸧ࡢᢎㄆࢆᚓ࡚⾜ࡗࡓ㸬⿕㦂⪅ࡣ㸪࿡ぬ࡟ᙳ㡪ࢆཬࡰࡍ⑌ᝈࢆᣢࡓࡎ㸪჎ྤ཯ᑕࡢ࡞
࠸೺ᖖⱝᖺ᭷ṑ㢡⪅14ྡ㸦ᖹᆒᖺ㱋27.4±2.4ṓ㸧ࢆ㑅ᢥࡋࡓ㸬ㄢ㢟ࡣ㸪ⱞ࿡่⃭࡜ࡋ࡚ྛ⿕㦂⪅ࡢㄆ▱㜈್࡟タᐃࡋࡓ࢟ࢽ࣮ࢿሷ㓟ሷ࡜ࡋ㸪Ὑί࡟ࡣேᕤၚᾮ(25mM KCl, 25mM NaHCO3)ࢆ⏝࠸ࡓ㸬ᐇ㦂᮲௳ࡣ㸪ཱྀ⵹ࢆ⿕そࡋ࡞࠸⿦⨨ࢆ⿦╔ࡋࡓ᮲௳ࢆࢥࣥࢺ࣮ࣟࣝ࡜ࡋ㸪ཱྀ⵹ࢆ⿕そࡍࡿ⿦⨨ࢆ⿦╔ࡋࡓ≧ែࢆཱྀ⵹⿕そ࡜ࡋࡓ2᮲௳࡛⾜ࡗࡓ㸬ᐇ㦂ࢹࢨ࢖ࣥࡣࣈࣟࢵࢡࢹࢨ࢖ࣥࢆ⏝࠸ࡓ㸬᧜ീ᫬࡟ࡣ㸪ࢫ࢖ࢵࢳᘧධฟຊ⿦⨨࡟ࡼࡾ࿡ぬㄆ㆑᫬ࡢࡳࢆᢳ
ฟࡋ㸪ᕪศኚ໬ࢆᶵ⬟⏬ീ࡜ࡋ࡚ྲྀࡾฟࡋࡓ㸬᧜ീ࡟ࡣ㸪7.0T㸦ࢸࢫࣛ㸧MR⿦⨨ࢆ⏝࠸࡚T1ᙉㄪ⏬
ീἲ࡟࡚ᙧែ⏬ീࢆ᧜ീࡋࡓᚋ࡟GREᆺ࢚ࢥ࣮ࣉ
ࣞࢼ࣮㸦EPIἲ㸧࡟ࡼࡗ࡚᧜ീࢆ⾜ࡗࡓ㸬⏬ീゎᯒ࡟ࡣ⬻ᶵ⬟⏬ീゎᯒࢯࣇࢺ㸦SPM8㸧࡟࡚⾜࠸㸪ゎᯒ࡟ࡼࡗ࡚ᚓࡽࢀࡓ㡿ᇦࡢMNI ᗙᶆࢆゎ๗Ꮫⓗᗙᶆ࡜㔜ࡡྜࢃࡏ࡚⬻㒊఩ࡢྠᐃࢆ⾜ࡗࡓ㸬ࡑࡢᚋ㸪࿡ぬ㛵㐃㡿ᇦࡈ࡜ࡢ㈿ά⠊ᅖ࡜⬻άື㔞ࢆẚ㍑᳨
ウࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ཱྀ⭍ෆ࡬ࡢⱞ࿡่⃭ࢆ୚࠼ࡓ㝿࡟㸪ࢥࣥࢺ࣮ࣟ
ࣝ࡜ཱྀ⵹⿕そࡢ୧᮲௳࡟࠾࠸࡚㸪୍ḟ࿡ぬ㔝ࡢᓥ㸦Insula㸧࡜๓㢌ᘚ⵹㒊㸦FOP㸧࠾ࡼࡧ஧ḟ࿡ぬ㔝ࡢ║❐๓㢌⓶㉁㸦OFC㸧࡟࠾࠸࡚୧ഃᛶࡢ㈿άࢆ
ㄆࡵࡓ㸬ࡉࡽ࡟㸪୍ḟ࿡ぬ㔝ࡢᓥ࡜๓㢌ᘚ⵹㒊࠾ࡼࡧ஧ḟ࿡ぬ㔝ࡢ║❐๓㢌⓶㉁ࡢྛ㡿ᇦ࡟ࡅࡿ㈿ά⠊ᅖࡢẚ㍑ࡣ㸪ཱྀ⵹ࡢ⿕そ࡟ࡼࡾ㸪᭷ព࡞పୗ
ࢆ♧ࡋࡓ㸬ࡲࡓ㸪⬻άື㔞ࡢẚ㍑ࡣ㸪୍ḟ࿡ぬ㔝ࡢᓥ࡜๓㢌ᘚ⵹㒊࡛ࡣ୧ഃ࡟࠾࠸࡚᭷ព࡞పୗࢆ
♧ࡋࡓ㸬ࡋ࠿ࡋ㸪஧ḟ࿡ぬ㔝ࡢ║❐๓㢌⓶㉁࡛ࡣ
᭷ព࡞ᕪࢆㄆࡵ࡞࠿ࡗࡓ㸦ᅗ㸧㸬ୖグ⤖ᯝ࠿ࡽ㸪ཱྀ⵹ࡢ⿕そࡣ୍ḟ࿡ぬ㔝ࡢάື㔞ࢆపୗࡉࡏ㸪୍ḟ࿡ぬ㔝ࡢᶵ⬟࡛࠶ࡿ࿡ࡢ㆑ู
⬟ࢆపୗࡉࡏࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ୖグࡼࡾཱྀ⵹ࢆ⿕そࡍࡿࢱ࢖ࣉࡢᗋ⩏ṑ⿦╔ࡣ㸪࿡ぬ㞀ᐖࢆច㉳ࡉࡏࡿྍ⬟ᛶࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬

Ύ

(%)
1.5

Ύ Ύ Ύ Ύ <0.05

1
0.5
0

InsulaInsula FOP FOP OFC OFC
L
R
L
R
L
R
ࢥࣥࢺཱྀ࣮ࣟࣝ⵹⿕そ ࿡ぬ㛵㐃㡿ᇦࡢ⬻άື㔞ࡢẚ㍑
ϫ㸬 ᩥ⊩1㸧 Ḉᗞᾈஅ㸪ᑠᯘ⌶ஓ㸬ୗ㢡ࡢ೫఩ࡀ⬻ᶵ⬟ᛂ

− 180 −

⟅࡟ཬࡰࡍᙳ㡪-functional MRIࢆ⏝࠸ࡓ᳨ウ-㸬ᒾ་኱ṑㄅ 2014㸹39㸸1-13㸬

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表 

2 ─ 3 ─ 14ࣄࢺୗ㢡㦵⮻ṑ㒊⓶㉁㦵࡟࠾ࡅࡿ⏕య࢔ࣃࢱ࢖ࢺ⤖ᬗ㓄ྥᛶゎᯒ

‫୕ۑ‬஭ᬛ἞  㸪㔝ᮏಇኴ㑻  㸪ຍ⸨ග㞝 㸪ᯇỌ ᬛ  㸪㜿㒊 ఙ୍  㸪బ⸨ ஽ 㸪ᒣୗ⚽୍㑻 

Alignment of Biological Apatite Crystallites in the Molar Part Cortical Bone of the Human Mandibleᮾிṑ⛉኱Ꮫཱྀ⭍೺ᗣ⮫ᗋ⛉Ꮫㅮᗙṑ⛉⿵⥛Ꮫศ㔝㸪 ᮾிṑ⛉኱Ꮫࢡࣛ࢘ࣥࣈࣜࢵࢪ⿵⥛Ꮫㅮᗙ㸪 ᮾிᨭ㒊 ᮾிṑ⛉኱Ꮫゎ๗Ꮫㅮᗙ㸪 ᮾிṑ⛉኱Ꮫཱྀ⭍⛉Ꮫ◊✲ࢭࣥࢱ࣮


Mitsui T  㸪 Nomoto S  㸪Kato M 㸪Matsunaga S  㸪Abe S 㸪Sato T 㸪 Yamashita S
Division of Prosthodontics㸪Department of Clinical Oral Health Science㸪Tokyo Dental College㸪
Department of Crown and Bridge Prosthodontics㸪Tokyo Dental college㸪 Tokyo Branch
Department of Anatomy㸪Tokyo Dental college Oral Health Science Center, Tokyo Dental CollegeϨ㸬 ┠ⓗ㦵ࡣ㸪እ㒊࠿ࡽࡢᵝࠎ࡞ᶵ⬟ᅽ࡟ᑐࡋ࡚㌟యࢆᨭ
࠼ࡿ㔜せ࡞ᙺ๭ࢆᯝࡓࡋ࡚࠸ࡿ㸬Wolff ࡣࡇࡢࡼ࠺
࡞ຊᏛⓗ⎔ቃ࡟᭱ࡶ㐺ࡋࡓᵓ㐀ࡀᖖ࡟ಖࡓࢀࡿ࡜࠸
࠺ᛂኚ๎ࢆሗ࿌ࡋ࡚࠸ࡿ  㸬ࡉࡽ࡟㸪Frost ࡽࡣ඲㌟
࡟ຍࢃࡿᵝࠎ࡞ᶵ⬟ᅽࡣ㒊఩࡟ࡼࡾ㐪࠸ࡀ࠶ࡿࡓࡵ
࡟㸪᭱㐺ᙉᗘ࡟ࡘ࠸࡚ࡶ㒊఩ࡈ࡜࡟␗࡞ࡿ࡜ሗ࿌ࡋ࡚࠸ࡿ  㸬ࣄࢺୗ㢡㦵ࡣ࿪ᄮᶵ⬟ᅽ࡞࡝ṑࢆ௓ࡋ࡚ཷࡅࡿ࣓
࢝ࢽ࢝ࣝࢫࢺࣞࢫࡢᙳ㡪࡟ࡼࡗ࡚㸪௚ࡢ㛗⟶㦵࡜ࡣ␗࡞ࡗࡓ」㞧࡞ᙧែࢆ࿊ࡋ࡚࠸ࡿ㸬ࡇࡢࡼ࠺࡞≉Ṧ࡞⎔ቃୗ࡟࠾࠿ࢀ࡚࠸ࡿ㢡㦵ࡢ㦵㉁ࢆᐃ㔞ⓗ࡟ホ౯ࡍࡿࡇ࡜ࡣ㸪ṑ⛉⿵⥛἞⒪ࢆ㐙⾜ࡍࡿ㝿ࡢ᝟ሗࢆᚓ
ࡿୖ࡛㠀ᖖ࡟㔜せ࡛࠶ࡿ㸬㏆ᖺ㸪㦵㉁ࡢ୍ࡘ࡛࠶ࡿ⏕య࢔ࣃࢱ࢖ࢺ㸦௨ୗ
BAp㸧⤖ᬗࡢ㓄ྥᛶ࡟ࡼࡿホ౯ࡀ⾜ࢃࢀ࡚࠸ࡿ㸬ࡇࡢ BAp ⤖ᬗࡢ㓄ྥᛶࡣ㸪ᒁᡤᛂຊ࡟ᑐࡋ࡚㦵ᐦᗘࡼࡾࡶ㗦ᩄ࡟཯ᛂࡍࡿࡇ࡜࠿ࡽ㸪㦵㉁ࡢ᪂ࡋ࠸ᣦᶆ
ࡢ୍ࡘ࡜ࡉࢀ࡚࠸ࡿ㸬ࣄࢺୗ㢡㦵࡟ᑐࡋ࡚ࡶ BAp⤖ᬗ㓄ྥᛶ࡟㛵ࡍࡿሗ࿌ࡀᩓぢࡉࢀࡿࡼ࠺࡟࡞ࡾ㸪ࡑࡢ᭷ຠᛶࡀ☜ㄆࡉࢀ࡚ࡁࡓ   㸬  ࡋ࠿ࡋ㸪ࣄࢺୗ㢡㦵࡟࠾ࡅࡿᑠ⮻ṑ㒊࠿ࡽ኱⮻ṑ㒊࡟࠿ࡅ࡚ࡢ BAp ⤖ᬗ㓄ྥᛶࢆ⏝࠸ࡓẚ㍑᳨ウࡣ⾜ࢃࢀ࡚࠸࡞࠸㸬ࡑࡇ࡛㸪ᡃࠎࡣᚤᑠ㡿ᇦ㹖⥺ᅇᢡἲࢆ⏝࠸࡚ BAp ⤖ᬗࡢ㓄ྥᛶࢆィ ࡋ㸪ࣄࢺୗ㢡㦵⮻ṑ㒊⓶㉁㦵࡟࠾ࡅࡿᵓ㐀≉ᛶࡢᐃ㔞ⓗホ౯ࢆ㒊఩ࡈ࡜࡟ẚ㍑᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬(310)㠃ࡢ㹖⥺ᅇᢡࣆ࣮ࢡࢆ⏝࠸࡚ᅇᢡᙉᗘẚࢆ⟬ฟࡋ㸪㏆㐲ᚰ᪉ྥ㸪ṑ㍈᪉ྥ㸪㢋⯉᪉ྥࡢࡑࢀࡒࢀ࡟
ᑐࡋ࡚ᐃ㔞ⓗ࡞ホ౯ࢆ⾜࠸ẚ㍑᳨ウࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ㏆㐲ᚰ᪉ྥࡢBAp⤖ᬗ㓄ྥᛶࡣ㸪㒊఩࡟ࡼࡿᕪ
ࡀㄆࡵࡽࢀ࡞࠿ࡗࡓ㸬ṑ㍈᪉ྥࡢBAp⤖ᬗ㓄ྥᛶࡣ㸪 76 㛫㒊ࡢṑᵴ㒊࡛ప࠸ഴྥࢆ♧ࡋࡓ㸬㢋⯉᪉ྥࡢBAp⤖ᬗ㓄ྥᛶࡣ㸪 65 㛫㒊࡛㧗࠸ഴྥࢆ♧ࡋࡓࡇࢀࡽࡢ⤖ᯝ࠿ࡽ㸪ࣄࢺୗ㢡㦵⮻ṑ㒊⓶㉁㦵ࡢᵓ㐀࡟ࡣ㸪᳜❧ࡍࡿṑࡢᙧែࡸࡑࢀ࡟௜㝶ࡍࡿᶵ⬟㐠ື࡞࡝ࡀᙳ㡪ࡋ࡚࠸ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬
 
 


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
  ᅗ ᚤᑠ㡿ᇦ;⥺ᅇᢡ⿦⨨(RINT2500 ϫ㸬 ᩥ⊩1)

ihre Bedeutung für die Frage vom Knochenwachstum.
Virchows Arch. Pathol. Anat. Physiol. Klin. Med
1870 ;50:389-450.
2)

ϩ㸬 ᪉ἲ
ヨᩱࡣᮾிṑ⛉኱Ꮫゎ๗Ꮫㅮᗙᡤⶶࡢ᪥ᮏேᡂே
㑇యࡼࡾ᥇ྲྀࡋࡓ㸬⮻ṑ㒊ညྜᨭᣢࢆ᭷ࡋ㸪ⴭࡋ࠸ྀ⏕ࡸ㢡㢦㠃ࡢ୙ㄪ࿴ࡢࡳࡽࢀ࡞࠸㸪᭷ṑ㢡ୗ㢡㦵
2 య࡜ࡋࡓ㸬㛵ᚰ㡿ᇦࡣ 54 㛫㒊㸪 65 㛫㒊㸪 6 ศᒱ
㒊㸪 76 㛫㒊࠾ࡼࡧ 7 ศᒱ㒊࡟࠾ࡅࡿṑᵴ㒊⓶㉁㦵
࡜ࡋࡓ㸬BAp ⤖ᬗ㓄ྥᛶࡢィ ࡟ࡣ཯ᑕἲ㸪㏱㐣ἲࡢゎᯒࡀྍ⬟࡞ᚤᑠ㡿ᇦ㹖⥺ᅇᢡ⿦್(RINT2500+㸪
Imaging plate㸪Rigaku)ࢆ౑⏝ࡋࡓ㸦ᅗ㸧㸬ࡑࡢᚋ c㍈᪉ྥࡢᙉࡉࢆ♧ࡍ(002)㠃࡜ c ㍈௨እࡢᙉࡉࢆ♧ࡍ

Wolff. J. Über die innere Architektur der Knochen und

Frost. HM. Bone “mass” and the “mechanostat”: aproposal. Anat. Rec 1987;219:1-9.

3)

Morioka T, Matsunaga S, Yoshinari M, Ide Y, Nakano T,
Sekine H, et al. Alignmentof

biologicalapatitecrystallites at first molar in human mandible corticalbone. Cranio 2012;30: 32-404)

− 181 −

Furuya H, Matsunaga S,Yoshinari M, Abe S, Ide Y.
Analysis of biological apatite crystal orientation in theanterior cortical bone of the human mandible using
microbeam X-ray diffractometry. MaterialsTransactions
2012;53:980-984.

第2日

日補綴会誌

第 3 会場

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 15ୖ㒊ᵓ㐀ࢆ㛗ᮇⓗ࡟Ᏻᐃࡉࡏࡿࡓࡵࡢ2nd stageࡢ⪃ᐹ‫‮ۑ‬ὸ៞୍㑻‫‮‬ὸࢹࣥࢱࣝࢡࣜࢽࢵࢡ ᮾிᨭ㒊Consideration of the second stage to stabilize superstructures in the long term
Yuasa K
Yuasa Dental Clinic,

Tokyo BranchϨ㸬 ┠ⓗ ࢖ࣥࣉࣛࣥࢺ࿘ᅖ࡟࠾ࡅࡿゅ໬ṑ⫗ࡢᚲせᛶ࡟㛵ࡋ࡚ࡣ㸪ᚲせㄽ࡜୙ᚲせㄽࡀᑐ❧ࡍࡿᙧ࡜࡞ࡾ
ᮍࡔࢥࣥࢭࣥࢧࢫࡣᚓࡽࢀ࡚࠸࡞࠸㸬ࡋ࠿ࡋ㸪࢖ࣥࣉࣛࣥࢺᇙධணᐃ㒊఩࡟࠾ࡅࡿゅ໬ṑ⫗ࡢ㔞㸦ᖜ࣭ཌࡳ㸧ࡀࡑࡢᚋࡢ࣓࢖ࣥࢸࢼࣥࢫ࡟࡜ࡗ࡚㔜せ࡛࠶ࡿࡇ࡜ࡣㄽࢆᚅࡓ࡞࠸㸬ࡑࡇ࡛㸪௒ᅇ㸪➹⪅ࡣ࢖ࣥࣉࣛࣥࢺ2ḟᡭ⾡ࢆ⑕౛࡟ࡼࡾ⾡ᘧࢆኚ࠼࡚⾜ࡗ࡚࠸ࡿࡢ࡛ࡇࡇ࡟ሗ࿌ࡍࡿ㸬ϩ㸬 ᪉ἲ
 2ᅇἲ࢖ࣥࣉࣛࣥࢺࡢ2ḟᡭ⾡ࢆ⾜࠺㝿࡟㸪㐟㞳ṑ⫗⛣᳜⾡࣭⤖ྜ⤌⧊⛣᳜⾡➼ࡢ㌾⤌⧊ࡢฎ⨨ࢆྠ᫬࡟⾜࠺ࡇ࡜ࡀከ࠸㸬ࡑࡢ㝿㸪ゅ໬ṑ⫗ࡢ㔞࠾ࡼࡧMGJࡢ఩⨨㸦㧗఩orప఩㸧ࡀ㠀ᖖ࡟㔜せ࡟࡞ࡗ࡚ࡃࡿ㸬ࡲࡓ㸪ୖ㢡࡜ୗ㢡࡛ࡣゎ๗Ꮫⓗ᮲௳ࡀ␗࡞ࡿࡓ
ࡵ㸦ୖ㢡ࡣ㢋ഃ࡟ࡢࡳMGJࡀ఩⨨ࡍࡿࡀ㸪ୗ㢡ࡢሙྜ㢋⯉ഃ࡜ࡶ࡟MGJࡀᏑᅾࡍࡿ㸬㸧㸪ษ㛤⥺ࡢ఩⨨ࢆኚ࠼ࡿࡇ࡜ࡶᚲせ࡛࠶ࡿ㸬ṧᏑࡍࡿゅ໬ṑ⫗ࢆ࠸࠿࡟ Ꮡࡍࡿ࠿ࡀ኱ษ࡛࠶ࡾ㸪㢋ഃࡲࡓࡣ⯉ഃ࡟⛣ືࡉࡏࡿࡇ࡜ࡶ࣏࢖ࣥࢺ࡜࡞ࡿ㸬௬࡟㸪ኳ↛ṑྠᵝ㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖ࡟3mmࡢ௜╔ṑ⫗࣭2mmࡢࢧࣝ࢝ࢫࡀᚲせ࡛࠶ࡿ࡜௬ᐃࡍ
ࡿ࡞ࡽࡤ㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖ࡟ࡣ5mmࡢゅ໬ṑ⫗ࡀᚲせ࡟࡞ࡿ㸬ࡑࡢࡇ࡜ࢆ๓ᥦ࡟ࡋ࡚㸪➹⪅ࡣ㸪ṑᵴ㡬࠿ࡽMGJࡲ࡛ࡢ㊥㞳࡟ࡼࡾ࢖ࣥࣉࣛࣥࢺ2ḟᡭ⾡ࡢ⾡ᘧࢆ6ࡘ࡟ศ㢮ࡋࡓ㸬
Ϩ. Standard Technique
ϩ. Buccal : Apically Positioned Flap
Ϫ. Buccal & Lingual : Apically Positioned Flap
ϫ. Buccal : Free Gingival Graft
Ϭ. Buccal : Free Gingival Graft , Lingual : Apically
Positioned Flap
ϭ. Buccal & Lingual : Free Gingival GraftϪ㸬 ⤖ᯝ࡜⪃ᐹ ṑࢆ႙ኻࡍࢀࡤ㸪ṑᵴ㦵ࡢ྾཰ࡣ࠶ࡿ⛬ᗘ㑊ࡅࡽࢀࡎ㸪ྠ᫬࡟ゅ໬ṑ⫗ࡢ㔞ࡶῶᑡࡍࡿ㸬ゅ໬ṑ⫗ࢆ Ꮡࡍࡿࡓࡵ࡟ࡣ㸪㸯ḟᡭ⾡᫬ࡢษ㛤⥺ࡢ఩⨨ࡶ㔜せ࡛࠶ࡿ㸬ṧᏑࡍࡿゅ໬ṑ⫗ࡢᖜ࣭ཌࡳࢆ
⢭ᰝࡋ࡚㸰ḟᡭ⾡࡟⮫ࡴࡇ࡜ࡣ㸪᭱⤊ୖ㒊ᵓ㐀࡟Ọ⥆ᛶࢆࡶࡓࡏࡿࡓࡵ࡟㠀ᖖ࡟㔜せ࡛࠶ࡿ㸬௒ᅇ㸪࢖ࣥࣉࣛࣥࢺ2ḟᡭ⾡ࡢ᪉ἲࢆศ㢮ࡍࡿࡇ࡜࡟ࡼࡗ࡚㸪⾡ᘧࡢ㑅ᢥࡀࡼࡾ᫂☜໬ࡉࢀࡓ㸬࢖ࣥࣉࣛࣥࢺ࡜ኳ↛ṑ࿘ᅖࡢṑ࿘⤌⧊ࢆẚ㍑ࡍ
ࡿ࡜㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖࡢ㌾⤌⧊࡬ࡢ⾑ᾮ౪⤥ࡣ୺࡟㦵⭷ୖ⾑⟶࠿ࡽ࡛࠶ࡾ㸪ኳ↛ṑࡢሙྜࡢ㦵⭷ୖ⾑⟶࣭ṑ᰿⭷࣭⤖ྜ⤌⧊࠿ࡽࡢ⾑ᾮ౪⤥࡜ẚ࡭㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖࡢ㌾⤌⧊࡬ࡢ⾑ᾮ౪⤥ࡣᑡ࡞࠸࡜⪃࠼ࡽࢀࡿ㸬ࡼࡗ࡚㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖࡢ㌾⤌⧊࡟እⓗ࡞่⃭ࡀຍࢃࡗࡓሙྜࡢ⏕యࡢ㜵ᚚᶵᵓࡣ㸪ኳ↛ṑࡢሙྜ࡜ẚ㍑ࡋ࡚ᙅ࠸ࡇ࡜ࡀண᝿ࡉࢀ
ࡿ1) 2) 㸬ࡲࡓ㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖ࡟ࣉ࣮ࣛࢡࡀ⵳✚ࡋࡓሙྜ㸪⮫ᗋⓗ࣭⤌⧊Ꮫⓗ࡟ࡑࡢ࿘ᅖ࡟ゅ໬ṑ⫗ࡀᏑᅾࡋࡓ᪉ࡀࡼࡾ⤌⧊◚ቯࡀᑡ࡞ࡃ㸪㦵ࡢ႙ኻ㔞ࡶᑡ࡞࠸࡜ᛮࢃࢀࡿ㸬3)ࡋࡓࡀࡗ࡚㸪࢖ࣥࣉࣛࣥࢺୖ㒊ᵓ㐀ࢆ㛗ᮇⓗ࡟Ᏻᐃࡉࡏࡿࡓࡵ࡟ࡣ㸪ゅ໬ṑ⫗ࡀ࠶ࡗࡓ᪉ࡀ᭷฼
࡛࠶ࡿ࡜⪃࠼ࡿ㸬ϫ㸬 ᩥ⊩1) Schroeder A, van der Zypen E, Stich H, Sutter F .
The reactions of bone, connective tissue, andepithelium to endosteal implants with titaniumsprayed surfaces. J Maxillofac Surg 1981 ; 9 : 1525.
2) Berglundth T, Lindhe J, Jonsson K, Ericsson I .
The topography of the vascular systems in the
periodontal and peri-implant tissues in the dog . J
Clin Periodontal 1994 ; 21 : 189-193.
3) Warrer K, Buser D, Lang NP, Karring T . Plaqueinduced peri-implants in the presence or absenceof keratinized mucosa. Clin Oral Impl Res 1995 ;6 : 131-138.

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日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 16ࢥ࣮ࣛࢤࣥᯫᶫᵓ㐀ࡀୗ㢡㦵ࡢ⬤ᛶ◚ቯᙉᗘ࡟ཬࡰࡍᙳ㡪‫ۑ‬ᡃዴྂΎኴ㸪ṇᮌ༓ᑜ㸪ᰘ⏣ 㝧*㸪ྥᆓኴ㑻㸪㏆⸨♸௓㸪୰ᮏဴ⮬㸪ᐑ㷂 㝯*㸪⣽ᕝ㝯ྖ஑ᕞṑ⛉኱Ꮫཱྀ⭍෌ᘓࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛศ㔝*᫛࿴኱ᏛṑᏛ㒊ṑ⛉⌮ᕤᏛㅮᗙThe effcts of collagen cross-links on micro-fragility of mandibular boneA
f h C㸪ShibatabliY*㸪Mukaiboubf Ad
d l T, Miyazakiid T*,dHosokawallRT㸪KondoY㸪Nakamoto
GanekoK㸪MasakiDepartment of Oral Reconstruction and Rehabilitation, Kyushu Dental University㸪*Department of Conservative Dentistry, Division of Biomaterials and Engineering, Showa University Schoolof DentistryϪ㸬 ⤖ᯝ࡜⪃ᐹ
 3Ⅼ᭤ࡆヨ㦂ࡢ⤖ᯝࡼࡾ㸪᭱኱Ⲵ㔜࡜◚᩿ຊࡣ
Met-diet⩌㸦287.26±24.10N, 254.09±43.88N㸧ࡢ᪉ࡀNorm-diet⩌㸦262.23±22.8N, 208.11±27.74N㸧ࡼࡾࡶ᭷ព࡟㧗࠸್ࢆ♧ࡋ, Fracture resistance࡟࠾࠸࡚ࡣMet-diet⩌㸦33.17±9.29 N㸧ࡢ᪉ࡀNorm-diet

 *3D

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 17-18㐌㱋ࢽ࣮ࣗࢪ࣮ࣛࣥࢻⓑⰍ✀㞤ᛶHealthy࢘ࢧࢠ20༉ࢆ⏝࠸ࡓ㸬ᐇ㦂⩌࡜ᑐ↷⩌ࡑࢀࡒࢀ10༉࡟ᑐࡋ࡚༸ᕢ᦬ฟᡭ⾡㸦OVX㸧ࡢᚋ㸪ᐇ㦂⩌10༉
࡟1%L-࣓ࢳ࢜ࢽࣥΰྜᅛᙧヨᩱࢆ1᪥࠶ࡓࡾ100g㸪
16㐌㛫⤥㣵ࡉࡏ㸪㧗࣍ࣔࢩࢫࢸ࢖ࣥ⾑⑕ࢆㄏⓎࡋࡓ㸦Met-diet⩌㸧㸬ᑐ↷⩌࡟ࡣᐇ㦂ື≀⏝ᅛᙧヨᩱࢆ⤥㣵ࡋࡓ㸦Norm-diet⩌㸧㸬16㐌⤒㐣ᚋࡢ๗᳨᫬࡟
኱⭣㦵,ୗ㢡㦵ࢆ᥇ྲྀࡋࡓ㸬኱⭣㦵ࡣ㦵ᙉᗘ ᐃ⿦⨨ MZ-500Sࢆ⏝࠸࡚3Ⅼ᭤ࡆヨ㦂ࢆ⾜࠸㸪◚᩿᫬㛫㸪◚᩿ຊ㸪◚᩿ኚᙧ㸪◚᩿࢚ࢿࣝࢠ࣮㸪᭱኱Ⲵ
㔜㸪Fracture resistance(᭱኱Ⲵ㔜-◚᩿ຊ)ࢆồࡵࡓ㸬୍᪉㸪ୗ㢡㦵࡟ᑐࡋ࡚ࡣNanoindentationヨ㦂ࢆ⾜ࡗࡓ㸬୕ゅ㗹≧ࡢࢲ࢖ࣖࣔࣥࢻᚤᑠᅽᏊ࡛ヨᩱ࡟ᑐࡋ࡚Ⲵ㔜㝖Ⲵヨ㦂ࢆ⾜࠺ࡇ࡜࡛㸪๛ᛶࡸᙎᛶ⋡㸪ᛂຊ⦆࿴࡟ࡘ࠸࡚ࡢ᳨ウࢆ⾜ࡗࡓ㸬⤫ィᏛⓗゎᯒ࡟ࡣStudents t-testࢆ⏝࠸᳨࡚ᐃࢆ⾜ࡗࡓ㸦P <0.05).

⩌㸦54.12±10.66 N㸧ࡼࡾࡶప࠸್ࢆ♧ࡋࡓ㸦P<0.
05㸧㸬୍᪉㸪ୗ㢡㦵࡟ᑐࡍࡿNanoindentationヨ㦂ࡢ⤖ᯝ㸪1࠾ࡼࡧ10Hzࡢ࿘Ἴᩘ࡟࠾࠸࡚㈓ⶶᙎᛶ⋡࠾ࡼࡧ⢓ᙎᛶࢆ⾲ࡍTanࡣMet-diet⩌ࡢ᪉ࡀNorm-diet⩌࡟ẚ࡭࡚᭷ព࡟ప࠸್ࢆ♧ࡋࡓࡇ࡜࠿ࡽ㸪Met-diet⩌ࡣୗ㢡㦵ࡢ๛ᛶࡀపୗࡋ࡚࠸ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬ࡉࡽ࡟␗࡞ࡿ㏿ᗘ࡛㈇Ⲵヨ㦂ࢆ⾜࠸㸪ᛂຊ⦆࿴ホ౯ࢆࡋࡓ࡜ࡇࢁ㸪Norm-diet⩌ࡣMet-diet⩌ࡼࡾᙧែᅇ᚟࡟ࡼࡿ኱ࡁ࡞ᛂຊ⦆࿴ࢆ♧ࡋࡓᅗ 㸬௨ୖࡼࡾ㸪AGEs࡞࡝ࡢ㠀㓝⣲ⓗࢥ࣮ࣛࢤࣥᯫᶫࡢቑຍࡣୗ㢡㦵ࡢ⬤ᛶࢆᘬࡁ㉳ࡇࡋ㸪㦵㉁ࡢຎ໬ࢆᣍࡃྍ⬟ᛶࡀ♧၀ࡉࢀࡓ㸬

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Ϩ㸬 ┠ⓗ
 㦵ᐦᗘ࡜㦵㉁࠿ࡽつᐃࡉࢀࡿ㦵ᙉᗘࡣ㸪ṑ⛉࢖ࣥࣉࣛࣥࢺ἞⒪࡟࠾࠸࡚ᴟࡵ࡚㔜せ࡞ᅉᏊ࡜⪃࠼ࡽࢀ࡚࠸ࡿࡀ㸪⾡๓CT᳨ᰝ࡛ࡢࣁࣥࢫࣇ࢕࣮ࣝࢻ್ࡔࡅ࡛ホ౯ࡍࡿࡇ࡜ࡣ㞴ࡋࡃ㸪ࡑࡢᐈほⓗホ౯᪉ἲࡣᮍࡔ☜❧ࡉࢀ࡚࠸࡞࠸㸬୍᪉㸪⢾ᒀ⑓ᛶ㦵⑕ࡸ㦵⢒㧼⑕ᝈ⪅࡟࠾࠸࡚Advanced glycation end
products (AGEs)࡟ࡼࡿ㠀㓝⣲ⓗࢥ࣮ࣛࢤࣥᯫᶫࡢ
㔞ࡀቑຍࡍࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ1)㸬ࡑࡇ࡛௒ᅇ
ᡃࠎࡣ㓟໬ࢫࢺࣞࢫ࡟ࡼࡾࢥ࣮ࣛࢤࣥࡢAGEsᯫᶫࡀቑຍࡍࡿ࡜ࡉࢀࡿ㧗࣍ࣔࢩࢫࢸ࢖ࣥ⾑⑕ࣔࢹࣝࢆ⏝࠸࡚ୗ㢡㦵ࡢ⬤ᛶ◚ቯᙉᗘ࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬

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Nanoindentationヨ㦂(㈓ⶶᙎᛶ⋡㸪Tanț)ϫ㸬 ᩥ⊩1) Saito M, Marumo K, Soshi S, Kida Y, Ushiku C, Shinohara A. Raloxifene ameliorates detr
imental enzymatic and nonenzymatic collagencross-links andand bone strength in rabbitswith hyperhomocysteinemia. Osteoporos Int. 2010; 21: 655-666.

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第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 17

㐃㏻ከᏍᛶࣁ࢖ࢻࣟ࢟ࢩ࢔ࣃࢱ࢖ࢺࢆ⏝࠸ࡓ㦵෌ᘓ㒊࡟࠾ࡅࡿ࢖ࣥࣉࣛࣥࢺᨭᣢࡢᵝ┦‫∾ۑ‬ཎຬ௓㸪ᅵ஭୍▮㸪ஂಖ㝯㟹㸪Ლཎᚿ✑㸪ຍ⸨ᐶ㸪Ἀెྐ㸪㉥ᕝᏳṇ*㸪ὠ㈡୍ᘯ

ᗈᓥ኱Ꮫ኱Ꮫ㝔་ṑ⸆ಖ೺Ꮫ◊✲⛉ඛ➃ṑ⛉⿵⥛Ꮫ◊✲ᐊ㸪*ዟ⩚኱ᏛṑᏛ㒊ṑ⛉⿵⥛ᏛㅮᗙThe aspect of implant-bone support ability in the reconstructed bone with interconnected porous calcium
hydroxyapatite㸬
Makihara Y, Doi K, Kubo T, Kajihara S, Kato K, Oki Y, Akagawa Y*, Tuga K
Department of Advanced Prosthodontics, Graduate School of Biomedical and Health Sciences, Hiroshima
University, *Department of Prosthetic Dentistry, School of Dentistry, Ohu UniversityϨ㸬 ┠ⓗ 㠀྾཰ᛶ⏕యᮦᩱ࡛࠶ࡿ㐃㏻ከᏍᛶࣁ࢖ࢻࣟ࢟
ࢩ࢔ࣃࢱ࢖ࢺ㸦IP-CHA㸧ࡣඃࢀࡓ⏕యぶ࿴ᛶ࠾ࡼࡧ㦵ఏᑟ⬟ࢆ᭷ࡋ࡚࠾ࡾ㸪㢡㦵㦵Ḟᦆ࡟⏝࠸ࡿᮦᩱ࡜ࡋ࡚ࡢ᭷⏝ᛶࡀ᫂ࡽ࠿࡟࡞ࡗ࡚࠸ࡿ1 㸧 㸬ࡋ࠿ࡋ࡞ࡀࡽ㸪IP-CHAࢆ⏝࠸࡚෌ᘓࡉࢀࡓ㦵⤌⧊࡟࠾ࡅࡿ࢖ࣥࣉࣛࣥࢺᇙධ࠾ࡼࡧ㦵ᨭᣢ࡟ࡘ࠸࡚ࡢሗ
࿌ࡣ࡯࡜ࢇ࡝↓࠸㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪IP-CHA࡟ࡼࡿ㦵෌ᘓ㒊࡟࢖ࣥࣉࣛࣥࢺࢆᇙධࡋ㸪ࡑࡢ࿘ᅖࡢ
㦵ᙧᡂ࡜㦵ᨭᣢࢆホ౯ࡍࡿࡇ࡜࡟ࡼࡾ㸪࢖ࣥࣉࣛࣥࢺ἞⒪࡟࠾ࡅࡿIP-CHAࢆ⏝࠸ࡓ㦵෌ᘓࡢ᭷⏝ᛶࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜࡟࠶ࡿ.
ϩ㸬 ᪉ἲᐇ㦂1-1㸸࢖ࢾ኱⭣㦵࡟෇ᰕ≧IP-CHAࣈࣟࢵࢡࢆሸධࡋ㸪12㐌ᚋ࡟࢖ࣥࣉࣛࣥࢺࢆ∦ഃࡀIP-CHAෆ࡟㸪཯ᑐഃࡀ᪤Ꮡ㦵࡟᥋ࡍࡿࡼ࠺࡟ᇙධࡋࡓ㸬࢖ࣥࣉࣛࣥࢺᇙධ12㐌ᚋ㸪⤌⧊Ꮫⓗほᐹ࠾ࡼࡧ㦵࢖ࣥࣉࣛࣥࢺ᥋ゐ⋡㸦BIC㸧ࢆ ᐃࡋࡓ.
ᐇ㦂1-2㸸࢖ࢾ኱⭣㦵࡟෇ᰕ≧IP-CHAࣈࣟࢵࢡࢆ
ሸධࡋ㸪12㐌ᚋ࡟IP-CHA୰ኸ࡟࢖ࣥࣉࣛࣥࢺࢆᇙ
ධ㸪ࡉࡽ࡟㸪㏆᥋ࡍࡿ᪤Ꮡ㦵㒊࡟ࡶ࢖ࣥࣉࣛࣥࢺ
ࢆᇙධࡋ㸪ࢥࣥࢺ࣮ࣟࣝ࡜ࡋࡓ㸬ᇙධ┤ᚋ࡟࢖ࣥࣉࣛࣥࢺᏳᐃಀᩘ㸦ISQ㸧್ࢆ ᐃࡋ㸪࢖ࣥࣉࣛࣥ
ࢺᇙධ12㐌ᚋ㸪ISQ್㸪㝖ཤࢺࣝࢡ್ࡢ ᐃ࠾ࡼࡧ⤌⧊Ꮫⓗほᐹࢆ⾜ࡗࡓ㸬ᐇ㦂2㸸࢖ࢾ㢡㦵࡟㦵❐ࢆᙧᡂࡋ㸪∦ഃ࡟㢛⢏≧
IP-CHA㸪཯ᑐഃ࡟⢊○⮬ᐙ㦵ࢆሸධ㸪12㐌ᚋ࡟㦵෌ᘓ㒊୰ኸ࡟࢖ࣥࣉࣛࣥࢺࢆᇙධ㸪ࡑࡢᇙධࢺࣝࢡ್ࢆ ᐃࡋࡓ㸬࢖ࣥࣉࣛࣥࢺᇙධ12㐌ᚋ㸪2ḟᡭ⾡ࢆ⾜࠸㸪Ⲵ㔜㈇Ⲵࢆ㛤ጞ㸪2㐌ࡈ࡜࡟ISQ್࠾ࡼࡧ࣌ࣜ࢜ࢸࢫࢺ್ࢆ ᐃࡋࡓ㸬Ⲵ㔜㈇Ⲵ㛤ጞ࠿ࡽ12㐌ᚋ㸪⤌⧊Ꮫⓗほᐹ࠾ࡼࡧBICࡢ ᐃࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ᐇ㦂1-1㸸IP-CHAࡢẼᏍෆ࡬ࡢ㦵ࡢᙧᡂ࠾ࡼࡧ࢖
ࣥࣉࣛࣥࢺ⾲㠃࡛ࡢ㦵᥋ゐࡀほᐹࡉࢀࡓ㸬ࡲࡓ㸪
BICࡣ୧⩌㛫࡟᭷ពᕪࡣ࡞࠿ࡗࡓ㸬ᐇ㦂1-2㸸ᇙධ12㐌ᚋࡢISQ್࡟࠾࠸࡚ࡣIP-CHA⩌ࡀ᪤Ꮡ㦵⩌ࡼࡾ᭷ព࡟㧗࠿ࡗࡓ㸬㝖ཤࢺࣝࢡ್
ࡣ㸪୧⩌㛫࡟᭷ពᕪࡣ࡞࠿ࡗࡓ㸬⤌⧊Ꮫⓗ࡟ࡣ㸪
IP-CHA⩌࠾ࡼࡧ᪤Ꮡ㦵⩌࡜ࡶ࡟ࢫࣞࢵࢻ࡟ἢࡗࡓ
㦵ࡢᙧᡂࡀほᐹࡉࢀࡓ.
 ᐇ㦂2㸸ᇙධࢺࣝࢡ್ࡣ㸪୧⩌㛫࡟᭷ពᕪࡣ࡞࠿ࡗࡓ㸬ISQ್࡛ࡣ㸪࢖ࣥࣉࣛࣥࢺᇙධ᫬࡟⮬ᐙ㦵⩌
ࡀIP-CHA⩌ࡼࡾ᭷ព࡟㧗࠸್࡜࡞ࡗࡓ㸬Ⲵ㔜㈇Ⲵ
㛤ጞ࠿ࡽ12㐌ᚋࡲ࡛㸪ࡍ࡭࡚ࡢᮇ㛫࡟࠾ࡅࡿISQ್࠾ࡼࡧ࣌ࣜ࢜ࢸࢫࢺ್࡛ࡣ㸪୧⩌㛫࡟᭷ពᕪࡣ࡞
࠿ࡗࡓ㸬⤌⧊Ꮫⓗ࡟ࡣ㸪୧⩌࡜ࡶ࢖ࣥࣉࣛࣥࢺ⾲㠃࡛ࡢ㦵᥋ゐࡀほᐹࡉࢀࡓ㸦ᅗ㸧㸬ࡲࡓ㸪BICࡣ୧⩌㛫࡟᭷ពᕪࡣ࡞࠿ࡗࡓ.
௨ୖࡢ⤖ᯝࡼࡾIP-CHA㦵෌ᘓ㒊࡟ᇙධࡋࡓ࢖ࣥ
ࣉࣛࣥࢺࡣ㸪㠀Ⲵ㔜᮲௳ୗ࡛࢜ࢵࢭ࢜࢖ࣥࢸࢢࣞ
࣮ࢩࣙࣥࢆ⋓ᚓࡋ㸪᪤Ꮡ㦵࡜ྠ⛬ᗘࡢ㦵ᨭᣢࢆㄆࡵࡿࡇ࡜㸪ࡉࡽ࡟㸪Ⲵ㔜᮲௳ୗ࡛ࡶ඘ศ࡞἞⒵ᮇ
㛫ࢆタᐃࡍࡿࡇ࡜࡟ࡼࡾ⢊○⮬ᐙ㦵࡛ࡢ㦵෌ᘓ㒊࡜ྠ➼ࡢ㦵ᨭᣢࢆᚓࡽࢀࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓ.

2ḟᡭ⾡12㐌ᚋࡢ⤌⧊Ꮫⓗほᐹϫ㸬 ᩥ⊩1) Kubo T, Doi K, Hayashi K, Morita K, Matsuura
A, Teixeira ER, Akagawa Y. Comparativeevaluation of bone regeneration using sphericaland irregularly shaped granules of interconnected
porous hydroxylapatite㸬A beagle dog study㸬J
Prosthodont Res 2011; 55: 104Ό109. − 184 −

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 18⪁ᖺᛶ㦵⢒㧼⑕ࣔࢹ࣐ࣝ࢘ࢫ᳨࡛ウࡋࡓࢳࢱࣥ࡬ࡢ⣸እ⥺↷ᑕ࡟ࡼࡿ㦵ఏᑟ⬟ࡢྥୖ‫⏣ྂۑ‬ᘯᶞ㸨㸪ᒣཱྀ኱㍜㸨㸪➉ෆ୍ኵ㸨㸪㸨㸨㸪ᐑ๓ ┿㸨㸪㸨㸨㸪኱㔝බ⛱㸨㸪ᬑᒣ⏣ᏹᡂ㸨㸪ᐑᮏెᏹ㸨㸪ᮧୖ ᘯ㸨㸪㸨㸨㸪᭹㒊ṇᕭ㸨㸨ឡ▱Ꮫ㝔኱ᏛṑᏛ㒊㧗㱋⪅ṑ⛉Ꮫㅮᗙ㸪㸨㸨ཱྀ⭍࢖ࣥࣉࣛࣥࢺ⛉Stimulation of Osteoconductivity by Ultraviolet Irradiation on Titanium Surfaces
in Senile Osteoporotic Model Mice in  and 
Furuta H㸨, Yamaguchi D㸨, Takeuchi K㸨, 㸨㸨, Miyamae S㸨, 㸨㸨, Ohno K㸨,Fuyamada H㸨, Miyamoto Y㸨, Murakami H㸨, 㸨㸨, Hattori M㸨㸨Department of Gerodontology, 㸨㸨Division of Oral Implantology,
School of Dentistry, Aichi Gakuin UniversityϨ㸬 ┠ⓗ 㦵⢒㧼⑕ࡣཱྀ⭍࢖ࣥࣉࣛࣥࢺ἞⒪࡟࠾ࡅࡿࣜࢫ
ࢡࣇ࢓ࢡࢱ࣮࡛࠶ࡿ࡜࠸ࢃࢀ࡚࠸ࡿ㸬ࡲࡓ㸪ཱྀ⭍࢖ࣥࣉࣛࣥࢺ࡟⏝࠸ࡽࢀࡿࢳࢱࣥࡣ㸪〇㐀࠿ࡽࡢ᫬㛫⤒㐣࡜࡜ࡶ࡟㦵ఏᑟ⬟ࡀపୗࡍࡿࡇ࡜ࡀሗ࿌
ࡉࢀ࡚࠸ࡿ㸬ࡑࡢᑐ⟇࡜ࡋ࡚㸪ࢳࢱࣥ⾲㠃࡬ࡢ⣸እ⥺㸦UV㸧↷ᑕ࡟ࡼࡾ㦵࢖ࣥࣉࣛࣥࢺ⤖ྜࡀᙉ໬࡛ࡁࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸯㸧㸬 ࡑࡇ࡛ᮏ◊✲ࡣ㸪⪁ᖺᛶ㦵⢒㧼⑕ࣔࢹ࣐ࣝ࢘ࢫ
㸦SAMP6㸧࡟࠾࠸࡚㸪UV↷ᑕࡀࢳࢱࣥࡢ㦵ఏᑟ⬟࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ 㦵࢖ࣥࣉࣛࣥࢺ⤖ྜࡢຊᏛⓗ᳨ウ⏝࡜ࡋ࡚┤ᚄ
0.8 mm㸪㛗ࡉ3 mmࡢࢳࢱࣥ࣡࢖ࣖ㸪⤌⧊Ꮫⓗ᳨ウ⏝࡜ࡋ࡚ཌࡉ0.5 mm㸪୍㎶2 mmࡢṇ᪉ᙧࢳࢱࣥࣉ
࣮ࣞࢺ㸪⣽⬊ᇵ㣴ᐇ㦂⏝࡜ࡋ࡚┤ᚄ20 mm㸪ཌࡉ1mmࡢࢳࢱࣥࢹ࢕ࢫࢡࢆస〇ࡋࡓ㸬ࡍ࡭࡚ࡢࢳࢱࣥ
ヨᩱࡣ㓟ฎ⌮㸪Ὑί㸪⁛⳦ࢆ⾜ࡗࡓ㸬ᖖ ᬯᡤ࡛90᪥㛫ಖ⟶ࡋࡓࡶࡢࢆOLD⩌㸪OLD⩌࡟⣸እ⥺↷ᑕࢆ⾜ࡗࡓࡶࡢࢆUV⩌࡜ࡋࡓ㸬ࡲࡓ㸪ࡍ࡭࡚ࡢᐇ
㦂ື≀࡟ࡣ16㐌㱋ࡢ㞝ᛶSAMP6ࢆ⏝࠸ࡓ㸬ຊᏛⓗ᳨ウ࡛ࡣ㸪12ᑿࡢ኱⭣㦵࡟OLD⩌㸪UV⩌ࡢࢳࢱࣥ࣡࢖ࣖࢆᇙධࡋ㸪ᇙධ14㸪21㸪28᪥ᚋ࡟኱⭣㦵ࢆ᥇ྲྀࡋࡓᚋ࡟ຊᏛヨ㦂ᶵ࡟ࡼࡾᅽ⦰Ⲵ㔜
㸦N㸧࡜ᅽධኚ఩㔞㸦m㸧ࢆ ᐃࡋࡓ㸬⤌⧊Ꮫⓗ᳨ウ࡛ࡣ6ᑿࡢ኱⭣㦵࡟ࢳࢱࣥࣉ࣮ࣞࢺ
ࢆᇙධࡋ㸪ᇙධ7᪥ᚋ࡟Calceinࢆ⭡⭍ෆᢞ୚ࡋ࡚⺯ගᶆ㆑ࢆ⾜࠸㸪14᪥ᚋ࡟኱⭣㦵ࢆ᥇ྲྀ㸪ᅛᐃ㸪ໟᇙᚋ㸪ษ∦ᶆᮏ㸦ཌࡉ200 m㸧ࢆస〇ࡋ㸪ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾ࢆ⏝࠸࡚㸪㦵࡜ࢳࢱࣥࣉ࣮ࣞࢺࡢ
᥋ゐ⋡ࢆ⟬ฟࡋࡓ㸬ࡲࡓ㸪ගᏛ㢧ᚤ㙾࡛⤌⧊ほᐹࢆ⾜ࡗࡓ㸬ࡉࡽ࡟㸪㟁Ꮚ⥺࣐࢖ࢡࣟ࢔ࢼࣛ࢖ࢨ࡟
ࡼࡾษ∦ᶆᮏࡢඖ⣲ศᯒ㸦Ca㸪P㸪Ti㸧ࢆ⾜ࡗࡓ㸬 ⣽⬊ᇵ㣴ᐇ㦂࡛ࡣ㸪6ᑿࡢ኱⭣㦵࡜⬯㦵࠿ࡽ᥇ྲྀࡋࡓ㦵㧊⣽⬊ࢆᇵ㣴ࡋ㸪7᪥ᚋ࡟⥅௦ᚋ㸪㦵ⱆ⣽⬊ᵝ⣽⬊ࡢㄏᑟᇵᆅࢆ⏝࠸࡚ࢳࢱࣥࢹ࢕ࢫࢡୖ࡛ᇵ
㣴ࡋ㸪4㸪7᪥ᚋ࡟⣽⬊ቑṪヨ㦂㸪7㸪14᪥ᚋ࡟ALPάᛶヨ㦂㸪14㸪21᪥ᚋ࡟▼⅊໬ࡢホ౯ࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ຊᏛⓗ᳨ウ࡟࠾࠸࡚㸪ࢳࢱࣥ࣡࢖ࣖᇙධ14㸪21
᪥ᚋ࡟࠾࠸࡚UV⩌ࡣOLD⩌࡜ẚ㍑ࡋ࡚ᅽ⦰Ⲵ㔜ࡢ᭱኱್ࡣ᭷ព࡟ୖ᪼ࡋࡓ㸬 ⤌⧊Ꮫⓗ᳨ウ࡟࠾࠸࡚㸪ࢳࢱࣥࣉ࣮ࣞࢺᇙධ14᪥ᚋ࡛ࡣ㸪UV⩌ࡣOLD⩌࡜ẚ㍑ࡋ࡚㦵࡜ࢳࢱࣥࣉ
࣮ࣞࢺࡢ᥋ゐ⋡ࡣ᭷ព࡟ୖ᪼ࡋࡓ㸬ษ∦ᶆᮏࡢඖ⣲ศᯒ࡛ࡣ㸪㦵㧊⭍ෆࡢࢳࢱࣥࣉ࣮ࣞࢺࢆ♧ࡍTi
࿘ᅖ࡟Ca࡜Pࡀ࡯ࡰྠ㒊఩᳨࡛ฟࡉࢀࡓ㸬ࡲࡓගᏛ㢧ᚤ㙾ീ࡛ࡣ㦵㧊⭍ෆ࡟㦵ᵝ⤌⧊ࡀほᐹࡉࢀࡓ㸬 ⣽⬊ቑṪヨ㦂࡟࠾࠸࡚㸪ᇵ㣴7᪥┠࡛ࡣUV⩌ࡣ
OLD⩌࡜ẚ㍑ࡋ࡚᭷ព࡟⣽⬊ᩘࡀከ࠿ࡗࡓ㸬ALPάᛶヨ㦂࡟࠾࠸࡚㸪ᇵ㣴7㸪14᪥┠࡛ࡣUV⩌ࡣ
OLD⩌࡜ẚ㍑ࡋ࡚᭷ព࡟ALPάᛶࡀ㧗࠿ࡗࡓ㸬▼⅊໬ࡢホ౯࡟࠾࠸࡚㸪ᇵ㣴14᪥┠࡛ࡣUV⩌ࡣOLD⩌࡜ẚ㍑ࡋ࡚᭷ព࡟ᰁⰍ㠃✚ࡣ኱ࡁ࠿ࡗࡓ.㸦ᅗ㸧 ௨ୖࡼࡾ㸪UV↷ᑕ࡟ࡼࡿࢳࢱࣥࡢ㦵ఏᑟ⬟ࡢྥୖࡣ㸪㦵⢒㧼⑕≧ἣୗ࡟࠾࠸࡚ࡶ᭷ຠ࡞ࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬▼⅊໬ࡢホ౯㸦Alizarin Red S ᰁⰍ㸧ϫ㸬 ᩥ⊩1) Aita H, Hori N, Takeuchi M et al. The effect ofultraviolet functionalization of titanium on
integration with bone. Biomaterials 2009; 30:1015̽1025㸬

− 185 −

第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 19㦵⢒㧼⑕࢖ࣥࣉࣛࣥࢺࣔࢹࣝ࡟࠾ࡅࡿపᙉᗘ㧗࿘Ἴ᣺ື่⃭࡜PTHࡢ㦵ᙧᡂಁ㐍ຠᯝ‫ۑ‬ᰘᮏ ᙬ㸪ᑠᕝ ᚭ㸪Duyck Joke*㸪Naert Ignace *㸪బࠎᮌၨ୍

ᮾ໭኱Ꮫ኱Ꮫ㝔ṑᏛ◊✲⛉ ཱྀ⭍ࢩࢫࢸ࣒⿵⥛Ꮫศ㔝㸪*࣮ࣝ࣋ࣥ࢝ࢯࣜࢵࢡ኱Ꮫ
Influence of whole-body vibration and parathyroid hormone on peri-implant bone healing andosseointegration in ovariectomized rats.
Shibamoto A㸪Ogawa T㸪Duyck J*㸪Naert I*㸪Sasaki K
Division of Advanced Prosthetic Dentistry㸪Tohoku University Graduate School of Dentistry㸪* Department of Prosthetic Dentistry, BIOMAT Research Cluster, Katholieke Universiteit LeuvenϨ㸬 ┠ⓗ 㦵⢒㧼⑕ᝈ⪅࡬ࡢ࢖ࣥࣉࣛࣥࢺ἞⒪ࡣ㸪㦵ᙉᗘࡢຎ໬࡟ࡼࡿึᮇᅛᐃࡢኻᩋ㸪㦵௦ㅰపୗ࡟ࡼࡿ
࢜ࢵࢭ࢜࢖ࣥࢸࢢ࣮ࣞࢩࣙࣥ⋓ᚓ୙Ⰻ࡞࡝ᵝࠎ࡞㞀ᐖࡀሗ࿌ࡉࢀ࡚࠾ࡾ㸪௒ᚋࡢ㧗㱋♫఍࡟ྥࡅ࡚
ࡇࢀࡽၥ㢟ࡢඞ᭹ࡀㄢ㢟࡛࠶ࡿ㸬ࡑࡢࡓࡵ₇⪅ࡽࡣపᙉᗘ㧗࿘Ἴ᣺ື่⃭ࡢ᭷ࡍࡿ㦵ᙧᡂάᛶຠᯝ
࡟㛵ࡍࡿ᳨ウࢆ㔜ࡡ࡚ࡁࡓ1)㸬ᮏ◊✲࡛ࡣ᣺ື่⃭࡟ຍ࠼㸪◚㦵⣽⬊ࢆᢚไࡍࡿ㦵⢒㧼⑕ࡢᶆ‽⸆㸪ࣅࢫ࣍ࢫ࣍ࢿ࣮ࢺ〇๣㸦BP㸧㸪࠶ࡿ࠸ࡣ㦵ⱆ⣽⬊⣔ࢆάᛶ໬ࡍࡿparathyroid hormone㸦PTH㸧〇๣ࡢే⏝ຠᯝ࡟ࡘ࠸࡚╔┠ࡋ㸪㦵⢒㧼⑕ࣔࢹࣝࣛࢵࢺ
ࡢ࢖ࣥࣉࣛࣥࢺ࿘ᅖ㦵࡟ᑐࡍࡿBP〇๣Alendronate㸦Ale㸧࡜PTH〇๣ࡢᙳ㡪ࡢẚ㍑㸪ࡉࡽ࡟ྛ⸆๣࡜
᣺ື่⃭࡜ࡢే⏝ຠᯝࡢ᳨ウࢆ┠ⓗ࡜ࡋࡓ㸬ϩ㸬 ᪉ἲ 11㐌㱋㞤ᛶWister⣔ࣛࢵࢺ࡟༸ᕢ᦬ฟ⾡ࢆ⾜࠸㸪2㐌㛫㣫⫱ᚋ㸪3⩌࡟ศࡅ⏕⌮㣗ሷỈ 5ml/᪥㸪Ale
15¡g/kg/᪥㸪PTH 40¡g/kg/᪥ࢆ3㐌㛫㸪⓶ୗᢞ୚ࡋࡓ㸬ࡑࡢᚋ㸪୧ഃ⬯㦵࡟ࢳࢱࣥ〇࢖ࣥࣉࣛࣥࢺ
㸦¢2mm×13mm㸧ࢆᇙධ㸪⩣᪥ࡼࡾᢞ⸆ࢆ෌㛤㸪ྛ⩌ࢆࡉࡽ࡟2⩌࡟ศࡅ㸪1⩌࡟ࡣ᣺ື่⃭⿦⨨
㸦Big Wave G-Master㸪᪫〇సᡤ㸪ᮾி㸪᪥ᮏ㸧࡟࡚ຍ㏿ᗘ0.5G㸪࿘Ἴᩘ50Hz㸪่⃭᫬㛫15ศ/᪥㸪㐌
5᪥ࡢ᮲௳࡛඲㌟ⓗ࡞పᙉᗘ㧗࿘Ἴ᣺ື่⃭㸦WBV㸧ࢆ௜୚ࡋࡓ㸬ᇙධᚋ 1㐌࠾ࡼࡧ 4㐌࡟࡚ᒕẅࡋ㸪∦ഃ⬯㦵ࡣ㝖ཤࢺࣝࢡヨ㦂࡟㸪ᑐഃࡣ¡CT ⏬ ീ ゎᯒ࠾ ࡼ ࡧ ⤌⧊ ᙧែ Ꮫ ⓗ ホ౯ ࡟౪ ࡋ ࡓ㸦ྛ⩌n=7㸧㸬¡CT⏬ീゎᯒ࡛ࡣ㸪㦵ᐦᗘࡢᣦᶆ࡜
ࡋ࡚࢖ࣥࣉࣛࣥࢺ࿘ᅖ⓶㉁㦵ཬࡧᾏ⥥㦵ෆ࡟タᐃࡋ ࡓ ROI ࡢ ┦ ᑐ ࢢ ࣞ ࢖ ್ 㸦Ỉ=0㸪 ࢖ ࣥ ࣉࣛ ࣥ ࢺ=100㸧ࢆホ౯ࡋࡓ㸬⤫ィᏛⓗ᳨ウࡣ㸪ᢞ୚⸆๣㛫㸪᣺ ື ่ ⃭ ࡢ ᭷ ↓ 㸪 1 㐌 ࡜ 4㐌 ࡜ ࡢ 㛫 ࡢ ẚ ㍑ ࡟ ࡣMultiple ANOVA ࢆ ⏝ ࠸ 㸪 ⩌ 㛫 ẚ ㍑ ࡟ ࡣ Tukey’s
HSD testࢆ⏝࠸ࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ 㝖ཤࢺࣝࢡ್ࡣ1㐌࡟ẚ࡭4㐌ࡢ⩌࡛㸪ࡲࡓSaline㸪Aleᢞ୚⩌࡜ẚ࡭PTHᢞ୚⩌࡛᭷ព࡟㧗ࡃ㸪PTH࡟

WBVࢆ௜ຍࡋࡓ⩌࡛ࡣ㸪1㐌㸪4㐌࡜ࡶ࡟௚⩌࡜ẚ
㍑ࡋ᭷ព࡞㧗್ࢆ♧ࡋࡓ㸦ᅗA㸧㸬
┦ᑐࢢࣞ࢖್ࡣ㸪⓶㉁㦵࡟࠾࠸࡚1㐌࡟ẚ㍑ࡋ࡚
4㐌㸪ࡲࡓWBV௜୚⩌ࡀ௜୚ࡋ࡞࠸⩌࡟ẚ࡭᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸬ᢞ୚⸆๣ࡢ㐪࠸࡟ࡼࡿᕪࡣㄆ
ࡵࡽࢀ࡞࠿ࡗࡓ㸬୍᪉㸪ᾏ⥥㦵࡛ࡣPTHᢞ୚⩌ࡣ
Saline㸪Aleᢞ୚⩌࡜ẚ࡭᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸬἞⒵ᮇ㛫㸪᣺ື่⃭ࡢ᭷↓࡟ࡼࡿ᭷ពᕪࡣㄆࡵࡽ
ࢀ࡞࠿ࡗࡓ㸦ᅗB㸧㸬 ௨ୖࡼࡾ㸪PTH࡟ࡣᙉຊ࡞࢖ࣥࣉࣛࣥࢺ࿘ᅖ㦵἞⒵ಁ㐍ຠᯝࡀ࠶ࡾ㸪PTH࡜WBVࡢే⏝࡟ࡼࡾ㸪࢖ࣥࣉࣛࣥࢺ࿘ᅖ㦵ᙧᡂࡀ┦஌ⓗ࡟ಁ㐍ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ᮏ⤖ᯝࡣ㸪㦵⢒㧼⑕ᝈ⪅࡟࠾࠸࡚㸪BP㛵㐃㢡㦵ቯṚࢆᅇ㑊ࡋ㸪ࡼࡾ☜ᐇ࠿ࡘຠ⋡ⓗ࡞࢖ࣥࣉࣛࣥࢺ἞⒪ࡀᮇᚅࡉࢀࡿࡶࡢ࡛࠶ࡿ㸬ᅗ ⤖ᯝ㸸㝖ཤࢺࣝࢡヨ㦂(A) 㸪¡CT ⏬ീゎᯒ(B)ϫ㸬 ᩥ⊩1) Ogawa T, Vandamme K, Zhang X et al.
Stimulation of titanium implant osseointegration
through high-frequency vibration loading isenhanced when applied at high acceleration.
Calcif Tissue Int 2014; 95: 467-75.

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日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 20ࢧࣉ࣓ࣜࣥࢺ⒪ἲࡣ࢖ࣥࣉࣛࣥࢺయ࿘ᅖ㦵ࡢ㦵ᙧᡂࢆಁ㐍ࡉࡏࡿ࠿㸽‫ۑ‬Ώ㎶୔⣫㸪୰⏣ᾈྐ*㸪㧘ᶫ༟⿱㸪⸨⏣ెዉ⨾㸪㇂ᮏᏳᾈ**㸪ᮌᮏ⤫*㸪Ἑ┦Ᏻᙪ*᪥ᮏ኱Ꮫ኱Ꮫ㝔ᯇᡞṑᏛ◊✲⛉᭷ᗋ⩏ṑ⿵⥛Ꮫᑓᨷ㸪*᪥ᮏ኱ᏛᯇᡞṑᏛ㒊᭷ᗋ⩏ṑ⿵⥛Ꮫㅮᗙ㸪᪥ᮏ኱ᏛᯇᡞṑᏛ㒊ṑ⛉⏕యᮦᩱᏛㅮᗙ
Do supplements therapy promote peri-implant bone formation ?
Watanabe T, Nakada H*, Takahashi T, Fujita K, Tanimoto Y**, Kimoto S*, Kawai Y*
Nihon University Graduate School of Dentistry at Matsudo, Removable Prosthodontics, Matsudo*Department of Removable Prosthodontics, Nihon University school of Dentistry at Matsudo**Department of Dental Biomaterials, Nihon University school of Dentistry at MatsudoϨ㸬 ┠ⓗ࢖ࣥࣉࣛࣥࢺయ࡜㦵࡜ࡢ osseointegration ࢆᚓࡿࡓࡵ࡟ 3 ~ 6 ࢝᭶ࡢ἞⒵ᮇ㛫ࢆᚲせ࡜ࡍࡿࡀ㸪ከࡃࡢᝈ⪅ࡣࡇࡢᮇ㛫ࡀ㛗࠸࡜ッ࠼࡚࠸ࡿ㸬ᚑࡗ࡚ࡇࡢᮇ㛫ࢆ▷⦰ࡉࡏࡿࡇ࡜ࡣ⮫ᗋୖ㔜せ࡞ㄢ㢟࡛࠶ࡿ㸬࢖ࣥࣉࣛࣥࢺయᇙධᚋࡢ἞⒵ᮇ㛫▷⦰ࡢࡓࡵከࡃࡢ◊✲ࡀ⾜ࢃࢀ࡚࠸ࡿࡀ㸪ࡑࡢ࡯࡜ࢇ࡝ࡀ
⾲㠃ฎ⌮ࡸ⾡ᘧ➼ࡢᒁᡤⓗ࡞࢔ࣉ࣮ࣟࢳ࡛࠶ࡿ㸬ᡃࠎࡣࢧࣉ࣓ࣜࣥࢺ⒪ἲ࡟ࡼࡿ඲㌟ⓗ࡞࢔ࣉ࣮ࣟ
ࢳࡀ࢖ࣥࣉࣛࣥࢺ἞⒪ᮇ㛫ࡢ▷⦰࡟ࡘ࡞ࡀࡿ࡜⪃࠼㸪㦵⢒㧼⑕ࡢ἞⒪࠾ࡼࡧண㜵ࡢࡓࡵ㛤Ⓨࡉࢀࡓ
Synthetic bone mineral㸦௨ୗ㸹SBM㸧ࢆ⤒ཱྀᦤྲྀࡉࡏ㸪࢖ࣥࣉࣛࣥࢺయ࿘ᅖ᪂⏕㦵ࡢ㦵ᙧᡂ࡟୚࠼ࡿᙳ㡪ࢆ᳨ウ
ࡋࡓ㸬
ϩ㸬 ᪉ἲ
SBM ࡣ LeGeros RZ1)ࡽࡢ᪉ἲ࡟ᚑ࠸CaHPO4࣭
2H2O㸪MgCl2 ࠾ࡼࡧ ZnCl2 ࢆ NaF ࠾ࡼࡧ K2CO3ࢆྵࢇࡔ⵨␃Ỉ࡛⁐ゎࡋຍỈศゎࡋ࡚స〇ࡋࡓ㸬ᐇ㦂ື≀ࡢ㣫ᩱࡣᑐ↷⩌࡜ࡋ࡚㏻ᖖ㣗㸦AIN-93M㸧
ࢆ౑⏝ࡋ㸪ᐇ㦂⩌࡜ࡋ࡚ AIN-93M ࠾ࡼࡧ SBM
࡛స〇ࡉࢀࡓ㣫ᩱࢆ౑⏝ࡋࡓ㸬ᐇ㦂ࡣ 6 㐌㱋᫬࡟ࣛࢵࢺࢆ↓సⅭ࡟ᑐ↷⩌㸦n=12㸧࠾ࡼࡧᐇ㦂⩌㸦n=12㸧࡟๭ࡾ௜ࡅ㣫ᩱࡢᦤྲྀࢆ㛤ጞࡋࡓ㸬 8 㐌㱋᫬࡟ᕥ኱⭣㦵࡟࢖ࣥࣉࣛࣥࢺయᇙධᡭ⾡ࢆ⾜࠸㸪ᇙධ 1 㐌㛫ᚋ㸪ྛ⩌ 6 㢌ࡢࣛࢵࢺࢆ↓సⅭ๭ࡾ
௜ࡅࡋ㸪ࡑࡢෆ 2 㢌࢝ࣝࢭ࢖ࣥ㸦20mg/kg㸧ࢆ㦵⭡⭍ෆὀᑕࡋ⺯ග㢧ᚤ㙾ほᐹࡋࡓ㸬௚ࡢ 4 㢌ࡣᘬࡁᢤࡁヨ㦂࡟ࡼࡿᘬࡁᢤࡁᙉᗘ࠾ࡼࡧ CT ᧜ീ࡟
ࡼࡿ BMDᐃ࡟๭ࡾᙜ࡚㸪࢖ࣥࣉࣛࣥࢺయᇙධ
2 㐌㛫ᚋ࡟኱⭣㦵ࢆ᦬ฟࡋヨᩱ࡜ࡋࡓ㸬ṧࡾࡢࣛࢵࢺࡣᇙධᚋ 4 㐌ᚋ࡟ྠᵝࡢ๭ࡾᙜ࡚ࢆࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹᑐ↷⩌࠾ࡼࡧᐇ㦂⩌ࡢᘬࡁᢤࡁᙉᗘ㸦ᅗ㸬1㸧ࡣ
ᇙධ 2 㐌㛫ᚋ࡟࠾࠸࡚ 2.08 ± 1.42 MPa㸪 12.45 ±4.28 MPa ࡛ᐇ㦂⩌ࡀ᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸦 <0.05㸧㸬ᇙධ 4㐌㛫ᚋ࡛ࡣ17.99 ± 3.20 MPa ࠾ࡼࡧ
35.31 ± 9.10 MPa ࡛ᐇ㦂⩌ࡀ᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸦 < 0.05㸧㸬ᑐ↷⩌࠾ࡼࡧᐇ㦂⩌ࡢ BMDᅗ㸬1 ᘬࡁᢤࡁᙉᗘ࠾ࡼࡧ BMD ࡢẚ㍑㸦ᅗ㸬1㸧ࡣᇙධ 2 㐌ᚋ࡟࠾࠸࡚ࡑࢀࡒࢀ666.95 ±77.00 mg/cm3㸪 1333.63 ± 109.51 mg/cm3 ࡛ᐇ㦂⩌ࡀ᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸦 < 0.05㸧㸬ᇙධ 4㐌㛫ᚋ࡛ࡣࡑࢀࡒࢀ 782.83 ± 46.46 mg/cm3 ࠾ࡼࡧ
1671.88 ± 334.55 mg/cm3 ࡛ᐇ㦂⩌ࡀ᭷ព࡟㧗࠸್ࢆ♧ࡋࡓ㸦 < 0.05㸧㸬⺯ග㢧ᚤ㙾ほᐹ࡛ࡣᑐ↷⩌ࡢᇙධ 2 㐌㛫ᚋ࡛⺯ගࢆ♧ࡉ࡞࠿ࡗࡓ㸬ᐇ㦂⩌ࡢ
ᇙධ 2 ࠾ࡼࡧ 4 㐌㛫ᚋ㸪ᑐ↷⩌ࡢᇙධ 4 㐌㛫ᚋ࡛ࡣ࢖ࣥࣉࣛࣥࢺయ࿘ᅖ࡟୙つ๎࡞ᖏ≧ࡢ⺯ගࢆ♧ࡋࡓ㸬
BMD ࡢ⤖ᯝࡣ࢖ࣥࣉࣛࣥࢺయ࿘ᅖࡢ㦵ࡀᐇ㦂⩌࡟࠾࠸࡚᪩ᮇ࡟ᙧᡂࡉࢀࡓࡇ࡜ࢆ♧ࡋ㸪ࡑࢀ࡟ࡼࡾᑐ↷⩌࡟ẚ࡭ᐇ㦂⩌ࡢᘬࡁᢤࡁᙉᗘࡀ㧗࠿ࡗࡓ࡜⪃࠼ࡽࢀࡿ㸬⺯ග㢧ᚤ㙾ほᐹࡢ⤖ᯝ࡟࠾࠸࡚
ࡶᐇ㦂⩌࡟࠾࠸࡚㦵ᙧᡂࡢಁ㐍ࢆ♧ࡋࡓࡇ࡜࠿ࡽ㸪
SBM ࡟ࡼࡾ࢖ࣥࣉࣛࣥࢺ࿘ᅖ᪂⏕㦵ࡢ㦵ᙧᡂࡀಁ㐍ࡉࢀࡓ࡜⪃࠼ࡽࢀࡿ㸬௨ୖ࠿ࡽ SBM ࡢ⤒ཱྀᦤྲྀࡣ࢖ࣥࣉࣛࣥࢺ࿘ᅖ
᪂⏕㦵ࡢ㦵ᙧᡂࢆಁ㐍ࡉࡏࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡾ㸪࢖ࣥࣉࣛࣥࢺ἞⒪ᮇ㛫▷⦰࡟ࢧࣉ࣓ࣜࣥࢺ⒪ἲࡀ
᭷ຠ࡛࠶ࡿ࡜♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) LeGeros RZ, Lin S, Rohanizadeh R et al.: Biphasic
calcium phosphate bioceramics: preparation,
properties and applications. J Mater Sci Mater Med.
2003; 14: 201-209.

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第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 21࢖ࣥࣉࣛࣥࢺࢆ⏝࠸ࡓࣈࣜࢵࢪࡢຊᏛⓗゎᯒ㸫ᇙධ఩⨨ࡢᙳ㡪㸫‫ۑ‬Ᏻ⏣⿱ᗣ㸪኱ᒣဴ⏕㸪୰ᯘ᫴ஓ㸪⏣ᡤ㔛⨾㸪῰㇂ဴຬ㸪Ọ஭ᰤ୍㸪ᯇὠ㞞㐨㸪▼ୖ཭ᙪ᪥ᮏ኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨ϩㅮᗙMechanical analysis of bridge using the implants-The effects of different placement sitesYasuda H㸪Ohyama T㸪Nakabayashi S㸪Tadokoro S㸪Shibuya N㸪Nagai E㸪Matsuzu M, Ishigami T
Department of Partial Denture Prosthodontics, Nihon University School of DentistryϨ㸬 ┠ⓗ ࢖ࣥࣉࣛࣥࢺࢆᨭྎ࡜ࡋࡓࣈࣜࢵࢪ࡟࠾࠸࡚ᇙ
ධ఩⨨࡟ࡼࡾ㸪ຍࢃࡿⲴ㔜࡟ᑐࡍࡿᙳ㡪ࡣ㸪␗࡞ࡿ1)㸬࢖ࣥࣉࣛࣥࢺ࡟㛵ࡍࡿຊᏛⓗᙳ㡪ࡢゎᯒࡣከᩘሗ࿌ࡉࢀ࡚࠾ࡾ㸪ࢫࢺࣞ࢖ࣥࢤ࣮ࢪἲ㸪ගᙎᛶᐇ㦂ἲ㸪᭷㝈せ⣲ἲ࡟ࡼࡿᡭἲࡀ୺࡟⾜ࢃࢀ࡚ࡁࡓ㸬࡞࠿࡛ࡶ᭷㝈せ⣲ἲࡣ㸪⏕యࡢᵓ㐀ࢆࡼࡾヲ⣽࡟෌⌧ࡋ㸪⢭⣽࡞ᣲືࡢࢩ࣑࣮ࣗࣞࢩࣙࣥࢆ⾜࠺஦ࡀྍ⬟࡛࠶ࡿ㸬ࡑࡇ࡛ᮏ◊✲࡛ࡣ࢖ࣥࣉࣛࣥࢺࢆᨭྎ࡜ࡋࡓࣈ
ࣜࢵࢪࡢᇙධ఩⨨ࡢ┦㐪ࡀ㸪࢖ࣥࣉࣛࣥࢺ㢕㒊⓶㉁㦵࡟ཬࡰࡍᙳ㡪ࢆ୕ḟඖ᭷㝈せ⣲ἲࢆ⏝࠸᳨࡚
ウࡋࡓ㸬
ϩ㸬 ᪉ἲ
 ୕ḟඖ᭷㝈せ⣲ࣔࢹࣝࡣ㸪ୗ㢡ᕥഃ➨஧ᑠ⮻ṑ㸪➨୍࠾ࡼࡧ➨஧኱⮻ṑࡢ㸱ṑḞᦆ⑕౛ࢆ᝿ᐃࡋࡓୗ㢡඲㢡ࣔࢹࣝࢆᵓ⠏ࡋࡓ㸬ᵓᡂせ⣲ࡣ㸪ṑ㸪⓶㉁㦵㸪ᾏ⥥㦵㸪ṑ᰿⭷㸪㢡ሐ⢓⭷㸪࢖ࣥࣉࣛࣥࢺ㸪ୖ㒊ᵓ㐀࡜ࡋࡓ㸬➨஧ᑠ⮻ṑ㸪➨஧኱⮻ṑ┦ᙜ㒊࡟࢖ࣥࣉࣛࣥࢺࢆ
ᇙධࡋ㸪ࣈࣜࢵࢪ࡛⿵⥛ฎ⨨ࡋࡓࣔࢹࣝࢆࣔ
ࢹ ࣝ $㸪 ➨ ஧ ᑠ ⮻ ṑ 㸪 ➨ ୍ ኱ ⮻ ṑ ࡟ ࢖ ࣥ ࣉ ࣛ ࣥࢺࢆᇙධࡋ㸪㐲ᚰᘏ㛗ࣈࣜࢵࢪ࡛⿵⥛ฎ⨨ࡋࡓ ࣔ ࢹ ࣝ ࢆ ࣔ ࢹ ࣝ %㸪 ➨ ୍ 㸪 ➨ ஧ ኱ ⮻ ṑ ࡟ ࢖ ࣥࣉࣛࣥࢺࢆᇙධࡋ㸪㏆ᚰᘏ㛗ࣈࣜࢵࢪ࡛⿵⥛ฎ ⨨ ࡋ ࡓ ࣔ ࢹ ࣝ ࢆ ࣔ ࢹ ࣝ &࡜ ࡋ 㸪 ィ 㸱 ࣔ ࢹ ࣝ ࢆ〇సࡋࡓ ᅗ 㸬 ቃ⏺᮲௳ࡣ㸪⏕య࡟㏆ఝࡋࡓ㛢ཱྀ㐠ື᫬ࡢ➽཰⦰ࢆ⪃៖ࡋࡓ᪉ἲ㸪ࡍ࡞ࢃࡕ㸪ည➽㸪ഃ㢌➽㸪ෆഃ⩼✺➽㸪እഃ⩼✺➽࠾ࡼࡧ㸪㢡஧⭡➽๓⭡ࡢྛ➽཰⦰㔞ࢆ⤯ᑐᗙᶆ⣔࡟࠾ࡅࡿ࣋ࢡࢺࣝ࡜ࡋ࡚᥮⟬ࡋ㸪ྛ➽௜╔┦ᙜ㒊࡟Ⲵ㔜ࡍࡿ᪉ἲࢆ⏝࠸ࡓ 㸬ゎᯒ㡯┠ࡣ㸪࢖ࣥࣉࣛࣥࢺ㢕㒊⓶㉁㦵ࡢ┦ᙜᛂຊศᕸ㸪࢖ࣥࣉࣛࣥ
ࢺ㢕㒊⓶㉁㦵ࡢ௵ពࡢィ Ⅼ㸶Ⅼࡢ┦ᙜᛂຊ್࡜ࡋ㸪ホ౯ࢆ⾜ࡗࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ ࡍ࡭࡚ࡢࣔࢹࣝ࡟࠾࠸࡚㸪࢖ࣥࣉࣛࣥࢺ㢕㒊⓶㉁㦵ࡢ┦ᙜᛂຊศᕸࡣ㸪᭱㐲ᚰ࡟ᇙධࡉࢀࡓ࢖ࣥ
ࣉࣛࣥࢺࡢ㐲ᚰഃ࡟ᛂຊࡢ㞟୰ࡀㄆࡵࡽࢀࡓ㸬
ࣔࢹࣝC࡜ẚ㍑ࡋ࡚㸪ࣔࢹࣝBࡢ᭱㐲ᚰࡢ࢖ࣥࣉ
ࣛࣥࢺ㢕㒊⓶㉁㦵ࡢ┦ᙜᛂຊ್ࡣ㸪኱ࡁ࠸ഴྥࡀ
ㄆࡵࡽࢀࡓ㸬ྛࠎࡢ㸰ᮏࡢ࢖ࣥࣉࣛࣥࢺ㢕㒊⓶㉁㦵ィ Ⅼࡢ┦ᙜᛂຊ್ࡢ⥲࿴࡟㛵ࡋ࡚ࡣ㸪ࣔࢹࣝA
࡜ẚ㍑ࡋ࡚㸪ࣔࢹࣝB㸪Cࡣ኱ࡁ࠸್࡛࠶ࡗࡓ㸬 ௨ୖࡢࡇ࡜࠿ࡽ㸪ୗ㢡ᕥഃ➨஧ᑠ⮻ṑ㸪➨୍኱⮻ṑ㸪➨஧኱⮻ṑḞᦆ⑕౛࡟ᑐࡋ㸪࢖ࣥࣉࣛࣥࢺ
ࢆ⏝࠸ࡓࣈࣜࢵࢪ࡛⿵⥛ฎ⨨ࡋࡓሙྜ㸪㏆ᚰᘏ㛗ࣈࣜࢵࢪ࡛ࡣ㸪㸰ᮏࡢ࢖ࣥࣉࣛࣥࢺ࡟㢧ⴭ࡞ညྜ
ຊࡢ㈇ᢸࡢᕪࡣ࡞ࡃ㸪㐲ᚰᘏ㛗ࣈࣜࢵࢪ࡛ࡣ㸪㈇ᢸࡀ㐲ᚰࡢ࢖ࣥࣉࣛࣥࢺ࡟㞟୰ࡍࡿ஦ࡀ㸪♧၀ࡉࢀࡓ㸬 ゎᯒࣔࢹࣝϫ㸬 ᩥ⊩1) Bo Rangert, Mech Eng, et al㸬Bending Ovwrload
and Implant Fracture:A Retrospective ClinicalAnalysis
Int J Oral Maxillfac Implants 1995; 10: 326-334
2) Korioth TW, Hannam AG, et al. Deformation of
the human mandible during simulated tooth
clenching.
J Dent Res 73 1974;73:56-66− 188 −

日補綴会誌 7･124 回特別号，2015

第2日

第 3 会場

一般口演発表2 ─ 3 ─ 22࢖ࣥࣉࣛࣥࢺᨭᣢࢆ฼⏝ࡋࡓ㒊ศᗋ⩏ṑࡢຊᏛⓗゎᯒ㸫࢖ࣥࣉࣛࣥࢺᇙධ఩⨨ࡢᙳ㡪㸫‫ۑ‬῰㇂ဴຬ㸪኱ᒣဴ⏕㸪୰ᯘ᫴ஓ㸪⏣ᡤ㔛⨾㸪Ᏻ⏣⿱ᗣ㸪኱㇂㈼஧㸪ᒸ⏣ಙኵ㸪▼஭ ᣅ㸪▼ୖ཭ᙪ᪥ᮏ኱ᏛṑᏛ㒊ṑ⛉⿵⥛Ꮫ➨ϩㅮᗙMechanical analysis of unilateral free-end defect implant-assisted removable partial dentures-The effects of different implant placement sitesShibuya N㸪Ohyama T㸪Nakabayashi S㸪Tadokoro S㸪Yasuda H㸪Ohtani K㸪Okada N㸪Ishii T㸪
Ishigami T
Department of Partial Denture Prosthodontics, Nihon University School of DentistryϨ㸬 ┠ⓗ㏆ᖺ㸪㐟㞳➃Ḟᦆ⑕౛࡟࠾࠸࡚㸪࢖ࣥࣉࣛࣥࢺ
ࡀ᭷ࡍࡿ㧗࠸ᨭᣢ⬟ຊࢆ฼⏝ࡋࡓྍ᧔ᛶ㒊ศᗋᆺ࣮࢜ࣂ࣮ࢹࣥࢳ࣮ࣕ㸦Implant Assisted Removable
Partial Denture ; IARPD㸧࡟ࡼࡿ⿵⥛἞⒪ࡢ㢖ᗘࡀ㧗ࡃ࡞ࡾࡘࡘ࠶ࡿ㸬IARPDࡣ࢖ࣥࣉࣛࣥࢺᅛᐃᛶ
⿦⨨࡟ẚ࡭㸪እ⛉ⓗ౵くࡀᑡ࡞ࡃ㸪࢖ࣥࣉࣛࣥࢺ
࡟ࡼࡿညྜᨭᣢᇦࡢ☜ಖ࡟ࡼࡾ⩏ṑࡢᶵ⬟ᛶ࡜Ᏻᐃᛶࡀྥୖࡍࡿ࡜࠸ࢃࢀ࡚࠸ࡿ1)ࡀ㸪ヲ⣽ࡣ᫂ࡽ࠿࡛ࡣ࡞࠸㸬ࡑࡇ࡛ᮏ◊✲࡛ࡣ㸪ୗ㢡∦ഃ㐟㞳➃Ḟᦆ⑕౛࡟࠾࠸࡚IARPD࡛⿵⥛἞⒪ࡋࡓሙྜࢆ᝿ᐃ
ࡋ㸪Ḟᦆ㒊㢡ሐ࡬ࡢ࢖ࣥࣉࣛࣥࢺᇙධ఩⨨ࡢ┦㐪ࡀᨭྎṑ࠾ࡼࡧ㸪⩏ṑ࡟ཬࡰࡍຊᏛⓗᙳ㡪ࢆ୕ḟඖ᭷㝈せ⣲ἲࢆ⏝࠸᳨࡚ウࡋࡓ㸬ϩ㸬 ᪉ἲゎᯒ࡟ࡣ㸪ỗ⏝᭷㝈せ⣲ゎᯒࣉࣟࢢ࣒ࣛANSYS
Rel.14.5ࢆ⏝࠸ࡓ㸬ᵓᡂせ⣲ࡣ㸪ṑ㸪⓶㉁㦵㸪ᾏ⥥㦵㸪ṑ᰿⭷㸪㢡ሐ⢓⭷㸪⩏ṑᗋ㸪ᨭྎ⿦⨨㸪඲㒊㔠ᒓෙ࠾ࡼࡧ࢖ࣥࣉࣛࣥࢺ࡜ࡋࡓ㸬ゎᯒࣔࢹࣝࡣ㸪ୗ㢡ᕥഃ➨஧ᑠ⮻ṑ㸪➨୍኱⮻ṑ࠾ࡼࡧ➨஧኱⮻ṑࢆḞᦆ࡜ࡋ㸪ᚑ᮶ࡢ㐟㞳➃⩏ṑ
(Conventional Removable Partial Denture ; CRPD)ࡢࡳ
࡛⿵⥛἞⒪ࢆ᝿ᐃࡋࡓࣔࢹࣝࢆࣔࢹࣝA㸪ࣔࢹࣝA
ࡢḞᦆ㒊㢡ሐࡢ➨஧ᑠ⮻ṑ┦ᙜ㒊㸪➨୍኱⮻ṑ࠾ࡼࡧ➨஧኱⮻ṑ┦ᙜ㒊࡟ࡑࢀࡒࢀ࢖ࣥࣉࣛࣥࢺࢆ1ᮏᇙධࡋࡓࣔࢹࣝࢆࣔࢹࣝB㸪C࠾ࡼࡧD࡜ࡋ㸪ィ4
ࣔࢹࣝࢆ〇సࡋࡓ㸬㒊ศᗋ⩏ṑࡢタィࡣ㸪ᕥഃ➨୍ᑠ⮻ṑ࡟┤᥋ᨭྎ⿦⨨࡜ࡋ࡚RPIࢡࣛࢫࣉ㸪㛫᥋ᨭྎ⿦⨨࡜ࡋ࡚ྑഃ➨୍ᑠ⮻ṑ࡟㏆ᚰࣞࢫࢺ㸪ྑഃ➨୍኱⮻ṑ࡟㏆ᚰࣞࢫࢺ௜஧⭎㖋ࢆタᐃࡋ㸪ࣜࣥ࢞ࣝࣂ࣮࡟࡚㐃⤖ࡍࡿタィ࡜ࡋࡓ㸬ቃ⏺᮲௳ࡣ㸪⏕య࡟㏆ఝࡋࡓ㛢ཱྀ㐠ື᫬ࡢ➽཰⦰ࢆ⪃៖ࡋࡓ᪉ἲࢆ⏝࠸ࡓ2)㸬ゎᯒ㡯┠ࡣ㸪ᨭྎṑ࠾ࡼࡧ⩏ṑᗋࡢኚ఩࡜ࡋࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹᨭྎṑࡢኚ఩࡟࠾࠸࡚㸪┤᥋ᨭྎ⿦⨨ࢆタ⨨ࡋ࡚࠸ࡿୗ㢡ᕥഃ➨୍ᑠ⮻ṑ࡛ࡣ㸪ࣔࢹࣝA࡛ࡣỿ
ୗࡋ࡞ࡀࡽ㐲ᚰഴᩳࡋ࡚࠸ࡿࡢ࡟ᑐࡋ㸪࢖ࣥࣉࣛࣥࢺᨭᣢࢆ᭷ࡍࡿࣔࢹࣝB㸪C㸪࠾ࡼࡧDࡣ㸪ỿୗ࠾ࡼࡧ㐲ᚰ᪉ྥ࡬ࡢኚ఩ࡀᢚไࡉࢀ㸪ኚ఩㔞ࡣ㸪ṑෙ㒊㸪ṑ᰿㒊࡜ࡶ࡟㸪ࣔࢹࣝA㸪B㸪C㸪Dࡢ㡰࡛ῶᑡࡋࡓ㸬㛫᥋ᨭྎ⿦⨨ࢆタ⨨ࡋ࡚࠸ࡿୗ㢡ྑഃ➨୍ᑠ⮻ṑ࠾ࡼࡧ➨୍኱⮻ṑ࡟ࡘ࠸࡚ࡣ㸪ࡍ࡭࡚ࡢࣔࢹࣝ㛫࡛ኚ఩࡟኱ࡁ࡞ᕪࡣㄆࡵࡽࢀ࡞࠿ࡗ
ࡓ㸬⩏ṑᗋࡢኚ఩࡛ࡣ㸪ࡑࡢ᪉ྥࡣ㸪ࡍ࡭࡚ࡢࣔ
ࢹ࡛ࣝ㸪㐲ᚰ⯉ഃ࠾ࡼࡧỿୗ᪉ྥ࡛࠶ࡾ㸪ኚ఩㔞ࡣ㸪ࡍ࡭࡚ࡢィ Ⅼ࡟࠾࠸࡚㸪ࣔࢹࣝA㸪B㸪C㸪
Dࡢ㡰࡛ῶᑡࡋࡓ㸬௨ୖࡢࡇ࡜࠿ࡽ㸪ୗ㢡ᕥഃ➨஧ᑠ⮻ṑ㸪➨୍኱⮻ṑ㸪➨஧኱⮻ṑḞᦆ⑕౛࡟ᑐ
ࡋ㸪IARPD࡛⿵⥛἞⒪ࢆࡍࡿሙྜ㸪࢖ࣥࣉࣛࣥࢺ
ࡣ᭱ࡶ㐲ᚰࡢ➨஧኱⮻ṑ┦ᙜ㒊࡟ᇙධࡍࡿࡇ࡜࡛㸪࢖ࣥࣉࣛࣥࢺᨭྎ⿦⨨࡜ࡋ࡚ࡢᨭᣢຠᯝࡣ㧗ࡃ㸪⩏ṑࡢᣲືࢆᢚไࡋ㸪┤᥋ᨭྎ⿦⨨ࢆタ⨨ࡋࡓᨭྎṑࡢỿୗ࠾ࡼࡧഴᩳࢆᢚไࡍࡿࡇ࡜ࡀ♧၀ࡉࢀ
ࡓ㸬


ϫ㸬 ᩥ⊩
1) Shamili RA,   Mandibular Kennedy Class 1
implant-tooth-borne removable partial denture: asystematic review. J oral Dental Rehabil 2010;
37: 225-234.
2) Korioth TW,    Deformation of the humanmandible during simulated tooth clenching.
Journal of Dental Research1994; 73: 56-66.

− 189 −

第2日

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日補綴会誌

7･124 回特別号，2015

一般口演発表2 ─ 3 ─ 23

⧞ࡾ㏉ࡋⲴ㔜ࡀᇵ㣴㦵⣽⬊ᵝ⣽⬊ࡢ࢔࣏ࢺ࣮ࢩࢫ࡜࣮࢜ࢺࣇ
࢓ࢪ࣮࡟୚࠼ࡿᙳ㡪‫*⥴⳯ⴥ✄ۑ‬㸪㯮ᔱఙ୍㑻**㸪ྑ⸨཭╩*㸪⃝℩ 㝯**㛗ᓮ኱Ꮫ኱Ꮫ㝔་ṑ⸆Ꮫ⥲ྜ◊✲⛉ཱྀ⭍࢖ࣥࣉࣛࣥࢺᏛศ㔝㸪**㛗ᓮ኱Ꮫ⑓㝔ཱྀ⭍࣭㢡࣭㢦㠃࢖ࣥࣉࣛࣥࢺࢭࣥࢱ࣮
Effect of Mechanical Repetitive Loading on Apoptosis and Autophagy in Rat Calvarial Osteocyte-like Cells

Inaba N*, Kuroshima S**, Uto Y*, Sawase T**Department of Applied Prosthodontics, Graduate School of Biomedical Sciences, Nagasaki University,**Oral and Maxillofacial Implant Center, Nagasaki University HospitalϨ㸬 ┠ⓗ ྍ᧔ᛶ⩏ṑ࡞ࡽࡧ࡟ኳ↛ṑࡸ࢖ࣥࣉࣛࣥࢺࢆ௓
ࡋࡓ⿵⥛⿦⨨࡟ࡣ㸪࿪ᄮࡸᄟୗ᫬࡟ຍࢃࡿ⧞ࡾ㏉ࡋⲴ㔜ࡀᜏᖖⓗ࡟㦵࡬ఏ㐩ࡉࢀࡿ㸬㏆ᖺ㸪Ⲵ㔜ఏ㐩࡟࠾ࡅࡿ㦵⣽⬊ࡢ㔜せᛶࡀሗ࿌ࡉࢀ࡚࠸ࡿࡀ1)㸪
㢡㦵࡟࠾ࡅࡿ㦵⣽⬊౫ᏑᛶⲴ㔜ఏ㐩ᶵᵓࡢゎ᫂ࡣ㸪ṑ⛉⿵⥛Ꮫࡢᇶ┙ᵓ⠏࡟ᚲせ୙ྍḞࡔ࡜ᛮࢃࢀࡿ㸬୍᪉㏆ᖺ㸪⣽⬊Ṛࡢࡦ࡜ࡘ࡟࣮࢜ࢺࣇ࢓ࢪ࣮࡜࠸࠺㔜せ࡞ᴫᛕࡀᥦၐࡉࢀࡓ㸬㐺ษ࡞࣮࢜ࢺࣇ࢓
ࢪ࣮ࡣ⣽⬊ࢆࣉࣟࢢ࣒ࣛṚ㸦࢔࣏ࢺ࣮ࢩࢫ㸧࠿ࡽಖㆤࡍࡿࡀ㸪㐣๫࡞࣮࢜ࢺࣇ࢓ࢪ࣮ࡣ⣽⬊ᵓᡂせ⣲ࢆ◚⥢ࡍࡿ≉ᚩࡀ࠶ࡾ㸪ᵝࠎ࡞⣽⬊ࡢᇶ♏◊✲ࡀ⾜ࢃࢀࠊὀ┠ࢆᾎࡧ࡚࠸ࡿ◊✲㡿ᇦ࡛࠶ࡿ㸬࡜ࡇࢁࡀ㸪Ⲵ㔜ࢆཷࡅࡓ㦵⣽⬊ࡢ࣮࢜ࢺࣇ࢓ࢪ࣮࡟
㛵ࡍࡿሗ࿌ࡣ࡯࡜ࢇ࡝࡞࠸ࡇ࡜࠿ࡽ㸪ᡃࠎࡣ㸪Ⲵ㔜ࢆཷࡅࡓ㦵⣽⬊ࡣ࣮࢜ࢺࣇ࢓ࢪ࣮࡜࢔࣏ࢺ࣮ࢩ
ࢫࡢ୧᪉ࡢไᚚࢆཷࡅࡿ࡜࠸࠺௬ㄝࢆ❧࡚ࡓ㸬ᮏ◊✲ࡢ┠ⓗࡣ㸪ᡃࠎࡀᶞ❧ࡋࡓ㦵⣽⬊ᵝ⣽⬊࡟⧞ࡾ㏉ࡋⲴ㔜ࢆ୚࠼㸪࢔࣏ࢺ࣮ࢩࢫ࡜࣮࢜ࢺࣇ
࢓ࢪ࣮࡟࡝ࡢࡼ࠺࡞ᙳ㡪ࢆཬࡰࡍ࠿ࢆ᫂ࡽ࠿࡟ࡍ
ࡿࡇ࡜࡟࠶ࡿ㸬ϩ㸬 ᪉ἲ 12㐌㱋ࡢWistar⣔ࣛࢵࢺࡢ㢌⵹㦵࠿ࡽ㏻ἲ࡟ᚑ࠸
㦵ⱆ⣽⬊ࢆศ㞳ᇵ㣴ᚋ㸪ࡇࢀࡽࢆCorning♫〇ࡢ࣐ࢺࣜࢤࣝࢆ୺ᡂศ࡜ࡋ࡚㓄ྜࡋࡓࢪ࢙ࣝ࡟᧛✀ࡋ㸪ࢩࣜࢥࣥࢳࣕࣥࣂ࣮࡛3ḟඖᇵ㣴ࡋࡓ㸬ᇵ㣴24᫬㛫ᚋ࠿ࡽఙᒎᅽ⦰⋡8 %࣭1 Hzࡢ᮲௳࡛つ๎ⓗ࡞⧞ࡾ㏉ࡋⲴ㔜㸦ᅽ⦰࡜ఙᒎ㸧ࢆ୚࠼㸪Ⲵ㔜௜୚ᚋ0᫬㛫㸪
24᫬㛫㸪96᫬㛫ᚋ࡟TRIZOLἲ࡛㑇ఏᏊࢆᅇ཰ࡋࡓ
㸦ྛ⩌ࡢnӍ3㸪Ⲵ㔜⩌㸧㸬࡞࠾㸪3ḟඖᇵ㣴࡜࠸࠺᮲௳࡟ᑐࡋ࡚ࡣ㸪࣐ࢺࣜࢪ࢙ࣝ࡞ࡋ࡛ࢳࣕࣥࣂ࣮
࡟᧛✀ࡋࡓ2ḟඖᇵ㣴࡜࠸࠺᮲௳ࢆࢥࣥࢺ࣮ࣟࣝ࡜
ࡋ㸦nӍ3㸧㸪㠀Ⲵ㔜ࡢ3ḟඖᇵ㣴⣽⬊ࢆ3ḟඖᇵ㣴ࡢⲴ㔜⩌࡟ᑐࡍࡿࢥࣥࢺ࣮ࣟࣝ࡜ࡋࡓ㸦ྛ⩌ࡢnӍ
3㸪㠀Ⲵ㔜⩌㸧㸬㦵ⱆ⣽⬊ࡢᶵ⬟㸪ศ໬⛬ᗘ㸪࢔࣏ࢺ࣮ࢩࢫ࡞ࡽࡧ࡟࣮࢜ࢺࣇ࢓ࢪ࣮࡟㛵㐃ࡍࡿ30ࡢ㑇ఏᏊゎᯒࢆᐃ㔞PCR࡛⾜ࡗࡓ㸬ࡉࡽ࡟㸪඲⩌ࡢ⣽⬊ᙧែ㸪ᩘ㸪ᴟᛶࢆᐃ㔞ゎᯒࡍࡿࡓࡵ㸪⣽⬊㦵᱁ࡢ⺯ගᰁⰍࢆ⾜ࡗࡓ㸦ྛ⩌ࡢnӍ3㸧㸬⤫ィศᯒࡣ㸪3⩌㛫ࡢẚ㍑࡟ࡣศᩓศᯒ࡜Tukeyࡢ᳨ᐃࢆ㸪2⩌㛫ࡢẚ㍑࡟ࡣStudent t-testࢆ⏝࠸ࡓ㸬Ϫ㸬 ⤖ᯝ࡜⪃ᐹ
1㸬3ḟඖᇵ㣴⣽⬊ࡣ㦵ⱆ⣽⬊ࢆศ໬ࡉࡏࡿ
 3ḟඖᇵ㣴ࡀ㦵ⱆ⣽⬊࡟୚࠼ࡿᙳ㡪ࢆ᳨⣴ࡍࡿࡓࡵ㸪㦵ⱆ⣽⬊࡜㦵⣽⬊ࡢᶵ⬟ࡸศ໬࡟㛵ࡍࡿ㑇ఏᏊࡢ᳨⣴ࢆ⾜ࡗࡓ㸬㦵ⱆ⣽⬊≉␗ⓗ㑇ఏᏊRunx2࡜
AlplࡢⓎ⌧ࡣ2ḟඖᇵ㣴⣽⬊࡛᭷ព࡟㧗ࡃ㸪㦵⣽⬊≉ ␗ ⓗ 㑇 ఏ Ꮚ Dmp1 ࡜ SOST ࡢ Ⓨ ⌧ ࡜ Tnfsf11
㸦RANKLࡢ㑇ఏᏊྡ㸧ࡢⓎ⌧ࡣ㸪3ḟඖᇵ㣴⣽⬊࡛᭷ព࡟㧗࠿ࡗࡓ㸬୍᪉⺯ගᰁⰍ࡛ࡣ㸪3ḟඖᇵ㣴⣽⬊ࡣ2ḟඖᇵ㣴⣽⬊࡜ࡣ඲ࡃᙧែࡀ␗࡞ࡾ㸪⣽⬊✺㉳ࢆከᩘฟࡋ㸪୍㒊ࡣ㏆᥋⣽⬊࡜ࡢ㐃⤖ീࢆ♧ࡋ㦵⣽⬊ᵝ⣽⬊ࡢᙧែࢆ♧ࡋ࡚࠸ࡓ㸬௨ୖ࠿ࡽ⥲ྜⓗ࡟ุ᩿ࡋ࡚㸪ᮏᐇ㦂᮲௳࡛3ḟඖᇵ㣴ࡋࡓ㦵ⱆ⣽⬊ࡣ㦵⣽⬊ᵝ⣽⬊࡟ศ໬ࡋࡓࡇ࡜ࡀศ࠿ࡗࡓ㸬
2㸬⧞ࡾ㏉ࡋⲴ㔜ࡣ㦵⣽⬊ᵝ⣽⬊ࡢ࢔࣏ࢺ࣮ࢩࢫ࡜
࣮࢜ࢺࣇ࢓ࢪ࣮࡟ᙳ㡪ࢆ୚࠼ࡿ ḟ࠸࡛㸪Ⲵ㔜ࡀ࢔࣏ࢺ࣮ࢩࢫ࡟㛵㐃ࡍࡿBCL࡜
Caspaseࣇ࢓࣑࣮ࣜ㸪࡞ࡽࡧ࡟࣮࢜ࢺࣇ࢓ࢪ࣮࡟୚
࠼ࡿᙳ㡪ࢆ᳨⣴ࡋࡓ㸬Ⲵ㔜௜୚ᚋ96᫬㛫࡛㸪࢔࣏ࢺ࣮ࢩࢫࢆಁ㐍ࡍࡿBcl2l11㸪Bak1㸪Casp7㸪Casp3
ࡢⓎ⌧ࡀ㠀Ⲵ㔜⩌࡜ẚ㍑ࡋ࡚᭷ព࡟పࡃ㸪࣮࢜ࢺࣇ࢓ࢪ࣮㛵㐃㑇ఏᏊࡢ࠺ࡕUlk1ࡢⓎ⌧ࡀ᭷ព࡟㧗࠿ࡗࡓ㸬ࡲࡓ⺯ගᰁⰍ࡟ࡼࡿ⣽⬊ᐃ㔞ゎᯒࡢ⤖ᯝ㸪Ⲵ㔜௜୚ᚋ96᫬㛫࡛ࡢ㦵⣽⬊ᵝ⣽⬊ᩘࡣⲴ㔜⩌࡛᭷ព࡟ቑຍࡋ㸪⯆࿡῝࠸ࡇ࡜࡟⣽⬊ᴟᛶࡣⲴ㔜ࡢ௜୚᪉ྥ࡟୍⮴ࡍࡿഴྥࢆ♧ࡋ࡚࠸ࡓ㸬௨ୖ࠿ࡽ㸪⧞ࡾ㏉ࡋⲴ㔜࡟ࡼࡿ㦵⣽⬊ᵝ⣽⬊ᩘࡢቑຍࡣ㸪ᢠ࢔࣏ࢺ࣮ࢩࢫస⏝࡜࣮࢜ࢺࣇ࢓ࢪ࣮ࡢάᛶ໬ࡢ୧⤒㊰࡟ࡼࡾไᚚࡉࢀ࡚࠸ࡿྍ⬟ᛶࡀ⪃࠼ࡽࢀ㸪ࡉࡽ࡟ࡣ⣽⬊ᴟᛶ࡟ࡶᙳ㡪ࡍࡿࡇ࡜ࡀ♧၀ࡉࢀࡓ㸬ϫ㸬 ᩥ⊩1) Chen JH, Liu C, You L, Simmons CA. Boning up
on Wolff's Law: mechanical regulation of thecells that make and maintain bone. J Biomech.
2010; 43: 108-118.

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