循環器内科学部⾨1

Kario K, Pickering TG, Umeda Y, Hoshide S, Hoshide Y, Morinari M, Murata M, Kuroda
T, Schwartz JE & Shimada K. Morning surge in blood pressure as a predictor of silentand clinical cerebrovascular disease in elderly hypertensives: a prospective study.
Circulation 107, 1401-1406 (2003).
http://www.ncbi.nlm.nih.gov/pubmed/12642361.

2

Hoshide S, Yano Y, Haimoto H, Yamagiwa K, Uchiba K, Nagasaka S, Matsui Y,Nakamura A, Fukutomi M, Eguchi K, Ishikawa J & Kario K. Morning and Evening HomeBlood Pressure and Risks of Incident Stroke and Coronary Artery Disease in theJapanese General Practice Population: The Japan Morning Surge-Home BloodPressure Study. Hypertension 68, 54-61 (2016).
http://www.ncbi.nlm.nih.gov/pubmed/27160200.

3

Kario K, Saito I, Kushiro T, Teramukai S, Tomono Y, Okuda Y & Shimada K. Morning
Home Blood Pressure Is a Strong Predictor of Coronary Artery Disease: The HONEST
Study. Journal of the American College of Cardiology 67, 1519-1527 (2016).
http://www.ncbi.nlm.nih.gov/pubmed/27150682.

4

Townsend RR, Mahfoud F, Kandzari DE, Kario K, Pocock S, Weber MA, Ewen S, Tsioufis
K, Tousoulis D, Sharp ASP, Watkinson AF, Schmieder RE, Schmid A, Choi JW, East C,Walton A, Hopper I, Cohen DL, Wilensky R, Lee DP, Ma A, Devireddy CM, Lea JP, Lurz
PC, Fengler K, Davies J, Chapman N, Cohen SA, DeBruin V, Fahy M, Jones DE,Rothman M, Bohm M & SPYRAL HTN-OFF MED trial investigators. Catheter-based
renal denervation in patients with uncontrolled hypertension in the absence ofantihypertensive medications (SPYRAL HTN-OFF MED): a randomised, shamcontrolled, proof-of-concept trial. Lancet 390, 2160-2170 (2017).
http://www.ncbi.nlm.nih.gov/pubmed/28859944.

5Kandzari DE, Bohm M, Mahfoud F, Townsend RR, Weber MA, Pocock S, Tsioufis K,Tousoulis D, Choi JW, East C, Brar S, Cohen SA, Fahy M, Pilcher G, Kario K & SPYRALHTN-ON MED Trial Investigators. Effect of renal denervation on blood pressure in thepresence of antihypertensive drugs: 6-month efficacy and safety results from theSPYRAL HTN-ON MED proof-of-concept randomised trial. Lancet 391, 2346-2355(2018).

http://www.ncbi.nlm.nih.gov/pubmed/29803589.
6

Kario K. Global Impact of 2017 American Heart Association/American College of
Cardiology Hypertension Guidelines: A Perspective From Japan. Circulation 137, 543545 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29431656.

7

Kario K, Bohm M, Mahfoud F, Townsend RR, Weber MA, Patel M, Tyson CC, Weil J,
Agdirlioglu T, Cohen SA, Fahy M & Kandzari DE. Twenty-Four-Hour Ambulatory Blood
Pressure Reduction Patterns After Renal Denervation in the SPYRAL HTN-OFF MED
Trial. Circulation 138, 1602-1604 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/30354518.

8

Kario K, Iwashita M, Okuda Y, Sugiyama M, Saito I, Kushiro T, Teramukai S & Shimada
K. Morning Home Blood Pressure and Cardiovascular Events in Japanese Hypertensive
Patients. Hypertension 72, 854-861 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/30354719.

9Fujiwara T, Yano Y, Hoshide S, Kanegae H & Kario K. Association of cardiovascularoutcomes with masked hypertension defined by home blood pressure monitoring in a
Japanese general practice population. JAMA cardiology 3, 583-590 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29800067.

10 Sasaki N, Nagai M, Mizuno H, Kuwabara M, Hoshide S & Kario K. Associations Between
Characteristics of Obstructive Sleep Apnea and Nocturnal Blood Pressure Surge.
Hypertension 72, 1133-1140 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/30354806.
11Kario K. Nocturnal hypertension: New technology and evidence. Hypertension 71, 9971009 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29712746.

12 Kario K, Chen CH, Park S, Park CG, Hoshide S, Cheng HM, Huang QF & Wang JG.
Consensus Document on Improving Hypertension Management in Asian Patients,Taking Into Account Asian Characteristics. Hypertension 71, 375-382 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29311253.

13 Kario K & Wang JG. Could 130/80 mm Hg be adopted as the diagnostic threshold andmanagement goal of hypertension in consideration of the characteristics of Asian
populations? Hypertension 71, 979-984 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29686008.
14 Hoshide S, Yano Y, Mizuno H, Kanegae H & Kario K. Day-by-Day Variability of Home
Blood Pressure and Incident Cardiovascular Disease in Clinical Practice: The J-HOP
Study (Japan Morning Surge-Home Blood Pressure). Hypertension 71, 177-184 (2018).
http://www.ncbi.nlm.nih.gov/pubmed/29133364.
15 Kario K, Okada K, Kato M, Nishizawa M, Yoshida T, Asano T, Uchiyama K, Niijima Y,
Katsuya T, Urata H, Osuga JI, Fujiwara T, Yamazaki S, Tomitani N & Kanegae H. 24Hour Blood Pressure-Lowering Effect of an SGLT-2 Inhibitor in Patients with Diabetes
and Uncontrolled Nocturnal Hypertension: Results from the Randomized, PlaceboControlled SACRA Study. Circulation 139, 2089–2097 (2019).
http://www.ncbi.nlm.nih.gov/pubmed/30586745.
16 Kario K, Thijs L & Staessen JA. Blood Pressure Measurement and Treatment Decisions.
Circ. Res. 124, 990-1008 (2019).
http://www.ncbi.nlm.nih.gov/pubmed/30920932.
17 Kario K, Kanegae H, Oikawa T & Suzuki K. Hypertension Is Predicted by Both Large andSmall Artery Disease. Hypertension 73, 75-83 (2019).
http://www.ncbi.nlm.nih.gov/pubmed/30571549.
18 Kario K, Kanegae H, Tomitani N, Okawara Y, Fujiwara T, Yano Y & Hoshide S. Nighttime
Blood Pressure Measured by Home Blood Pressure Monitoring as an Independent
Predictor of Cardiovascular Events in General Practice. Hypertension 73, 1240-1248(2019).
http://www.ncbi.nlm.nih.gov/pubmed/31006331.
19 Kario K, Weber MA, Mahfoud F, Kandzari DE, Schmieder RE, Kirtane AJ, Bohm M,Hettrick DA, Townsend RR & Tsioufis KP. Changes in 24-Hour Patterns of Blood
Pressure in Hypertension Following Renal Denervation Therapy. Hypertension,
HYPERTENSIONAHA11913081 (2019).[in press]http://www.ncbi.nlm.nih.gov/pubmed/31256723.
20 Kario K, Shimbo D, Hoshide S, Wang JG, Asayama K, Ohkubo T, Imai Y, McManus RJ,
Kollias A, Niiranen TJ, Parati G, Williams B, Weber MA, Vongpatanasin W, Muntner P &Stergiou GS. Emergence of Home Blood Pressure-Guided Management of Hypertension
Based on Global Evidence. Hypertension, HYPERTENSIONAHA11912630 (2019). [inpress]
http://www.ncbi.nlm.nih.gov/pubmed/31256719.