1

Association of admission functional status and body mass index with mortality in patients

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receiving chronic dialysis: A nationwide observational cohort study

34Shintaro Mandai1*, Takaaki Koide1, Tamami Fujiki1, Yutaro Mori1, Fumiaki Ando1, Koichiro

5Susa1, Takayasu Mori1, Soichiro Iimori1, Shotaro Naito1, Eisei Sohara1, Shinichi Uchida1,

6Kiyohide Fushimi2, and Tatemitsu Rai1

781

9and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan

Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical

102

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Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan

Department of Health Policy and Informatics, Graduate School of Medical and Dental Sciences,1213

S Mandai and T Koide contributed equally.

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Corresponding author: Shintaro Mandai

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Department of Nephrology, Graduate School of Medical and Dental Sciences, Tokyo Medical

17and Dental University

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1-5-45 Yushima, Bunkyo, Tokyo 113-8519, Japan

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Tel: +81-3-5803-5214; Fax: +81-3-5803-5215; E-mail: smandai.kid@tmd.ac.jp

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Figure S1. Patient flowchart.

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Figure S2. A risk matrix for in-hospital mortality according to admission functional status,

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age, and BMI categories among various clinical subgroups.

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Multivariable logistic regression models were performed to assess the relationship between the27risk stratification matrix based on functional status, age, and BMI categories and mortality risk

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according to various subgroups including sex (a), diabetes mellitus (b), CVD (c), and Charlson

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comorbidity index score (d). The odds ratio with 95% CI and numbers of events and individuals

30are described for each category. Models were adjusted for sex, dialysis modality, and Charlson

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comorbidity index. CVD was defined as any of myocardial infarction, congestive heart failure,32

peripheral vascular disease, or cerebrovascular disease.

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ADL, activities of daily living; BMI, body mass index; CCI, Charlson comorbidity index; CVD,

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cardiovascular disease; OR, odds ratio

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Table S1. Impact of requirement for assistance in feeding, transferring, going to toilet, ordressing on in-hospital mortality in elderly subjects on maintenance dialysis.
Variable
Disability with feeding
Disability with transferring
Disability with toileting
Disability with dressing
Disability with bathing

No. of Events/N
1,623/13,996
2,340/27,061
2,188/22,533
2,234/23,572
2,372/28,156

OR (95% CI)
Crude OR
Adjusted ORa
5.59 (5.22–5.98)
4.45 (4.14–4.77)
5.30 (4.95–5.67)
4.38 (4.08–4.70)
5.72 (5.35–6.12)
4.70 (4.38–5.04)
5.67 (5.30–6.07)
4.64 (4.32–4.98)
5.20 (4.85–5.57)
4.29 (3.99–4.60)

aAdjusted for age, sex, body mass index, dialysis modality, and Charlson comorbidity index. CI,confidence interval; OR, odds ratio

5414243444546

Table S2. Association between disability types and risk of higher hospital length of stay andmedical cost in dialysis patients.
Category
Long length of stay (≥30 days)
Disability with feeding
Disability with transferring
Disability with toileting
Disability with dressing
Disability with bathing
Highest quartile of medical cost
Disability with feeding
Disability with transferring
Disability with toileting
Disability with dressing
Disability with bathing

No. of Events/N

OR (95% CI)
Crude OR
Adjusted ORa

5,454/13,996
9,411/27,061
8,363/22,533
8,576/23,572
9,860/28,156

3.28 (3.15–3.40)
3.29 (3.18–3.39)
3.49 (3.38–3.61)
3.40 (3.29–3.52)
3.43 (3.32–3.54)

2.96 (2.84–3.08)
3.03 (2.93–3.14)
3.21 (3.11–3.33)
3.14 (3.03–3.25)
3.18 (3.08–3.29)

4,369/13,996
8326/27,061
7,085/22,533
7,342/23,572
8,615/28,156

1.43 (1.38–1.49)
1.49 (1.44–1.54)
1.52 (1.47–1.57)
1.50 (1.45–1.55)
1.48 (1.44–1.53)

1.40 (1.34–1.45)
1.46 (1.41–1.51)
1.49 (1.44–1.54)
1.47 (1.42–1.52)
1.46 (1.41–1.50)

aAdjusted for age, sex, body mass index, dialysis modality, and Charlson comorbidity index. CI,
confidence interval; OR, odds ratio

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