医療経済学 定義・構成 田倉智之
実体経済（ＧＤＰ）と研究実績（論文数）
相関分析 検定ｐMESSAGE FROM THE ASSOCIATE EDITOR

Background and Current Trends in Medical Economics
Research in the Circulatory Field― What to Expect in Circulation Reports ―Tomoyuki Takura, PhD

Increasing Concerns With Medical Economics
Medical economics is an area of study encompassing medical science and economics that deals with a wide varietyof topics and issues related to the medical and healthcare field. The primary objective of medical economics is toanalyze diverse phenomena (e.g., technology, management, policy) occurring in relation to medical systems andclinical practice using methodologies of economics, including econometrics, value evaluation, decision making,and behavioral science, as well as medical statistics, to contribute to the advancement of both medical systems
and public health and welfare. As part of efforts to achieve these objectives, medical economics research, fromthe standpoint of a group of personnel involved in the medical field, particularly focuses on discussing
approaches to optimizing cost effectiveness and maximizing the happiness (i.e., quality of life) of patients, theirfamilies, and the general public as a whole. Separately, from the standpoint of ensuring social equity, medical
economics research is expected to present academic concepts and supporting rationales based on discussions of
the rational allocation of medical resources (e.g., public expenditure on universal healthcare).1
Medical economics is steadily raising concerns among both the general citizenry and medical personnel
engaged in clinical practice, and an increasing number of reports, including clinical studies, are emerging fromthis area of study. In the background of such a move lies the fact that medical costs are growing at substantiallyhigh rates globally, because of sharply increasing rates of morbidity, multiple stratification of diseases, andadvancements in medical technology. Innovation in medical technology is costly, and effective implementationof innovations depends on larger budgets and infrastructure of research and development (R&D) systems amid
the complicating and diversifying effects of discovery (or component) technologies. This in turn indicates theincreasing emphasis placed on economic themes among the main issues in the medical and healthcare field.
One example of this increasing concern in medical economics is the year-by-year increase in the number ofarticles on medical economics in the circulatory field accessed on PubMed, which is operated by the National
Center for Biotechnology Information: compared with only 3 reports published in 1985, this number had grown
to 90 by 2016. When the number of medical economics articles in the circulatory field is expressed as a ratio of
the total number of the articles in the same field, the annual increase in publication in the 2010‒2014 and2015‒2017 periods was 4.7- and 6.4-fold the number in the 1985‒1989 period, respectively (Figure 1).2
There are diverse backgrounds to the increase in medical economics articles. Regarding financial burden,
annual national health expenditures showed a 1.3-fold increase in the ratio to gross domestic product (GDP)over the 3-year period from 2015 to 2017 compared with the ratio over the 1985‒1989 period in both the OECDand G20 countries (Figure 1).3 A comparison of the ratio of national health expenditures with the number ofDepartment of Healthcare Economics and Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Mailing address: Tomoyuki Takura, PhD, MEng, Department of Healthcare Economics and Health Policy, Graduate School ofMedicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.   E-mail: ttakura@m.u-tokyo.ac.jp
ISSN-2434-0790   All rights are reserved to the Japanese Circulation Society. For permissions, please e-mail: cj@j-circ.or.jp
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TAKURA T

Figure 1.   Annual ratio of the number of medical economics articles in the circulatory field to the total number of the articles
in the same field and the ratio of the total national health expenditures to gross domestic product (GDP) (OECD and G20
countries: data lacking for some countries in the 1980 s). Total national health expenditures were estimated based on “HealthExpenditure as a Percent of Gross Domestic Product: OECD statistics from 1985 to 2017”. The number of medical economics
articles in the circulatory field was estimated based on the database of PubMed (1985–2017). (Search keywords: Circulation
AND Health economics [OR: Cost-effectiveness, Medical economics, Economic evaluation, Socioeconomics]).

medical economics articles indicates that the number of articles increased as the ratio of the expenditure increased
and vice versa with a slight time lag (Spearman’s rank correlation coefficient: r2=0.964, P<0.01). This trend showsthat an increase in financial burden makes medical economics issues apparent, leading to increases in concern
about and research into medical economics-related subjects.

Concept of Medical Economics and Recent Subjects of Economic Research
The following is an additional discussion of the concept of medical economics as briefly described above. Medicaleconomics articles in the circulatory field may be roughly classified into macro and micro subjects (Figure 2).
Macro subjects include social security-related issues that are concerned with financial resources for medicalinsurance systems; health policy-related issues covering medical services;4–6 and, although less frequently studied,
medical industry-related issues, including systems for new drug development, systems for medical device supply,and model development of genetic diagnosis.7,8 Micro subjects include human resources management, which isessential for administration of medical institutions; safety management; and medical economics research, includingeconomic evaluation of team-based care and inter-institutional collaboration.9 The number of articles is also
increasing in the areas of economic evaluation (including cost-effectiveness assessment) of medicines, medical
devices, and medical-care information systems.10 In addition, there are sporadic instances of research in which
behavior modifications in patients, their families, and medical personnel are examined from a medical economics
viewpoint by taking into account desired forms of decision making and support measures.11
In recent years, it has become fairly common for macro subjects to be cross-sectionally discussed with micro
subjects, as seen in the education of medical personnel and the health literacy of patients. There are also cases inCirculation Reports Vol.0, July 2018

Medical Economy

3Figure 2.   Structure of the main subjects in health economics (medical economics in the broad sense). (Modified withpermission from original reported (Figure 2) by Takura T.1) ICT, Information and Communication Technology.

which the economic value of aspects of the healthcare system, such as treatment modalities, is analyzed from anew methodological point of view by applying the parameters of not only patient outcomes but also the values
to the public. In the not-too-distant future, it will become more common to see, even in the circulatory field, themore active pursuit of socioeconomic research using, for example, practice models of therapy based on new
strategies made feasible by progress in medical information and communication technologies, and improvementin other infrastructure environments (Figure 2).

Circulatory Field and Medical Economics: Vision and Values of Circulation Reports
Circulation Reports will explore the subjects related to the economics of health and medical in the circulatory
field in depth, with due consideration of the aforementioned backgrounds. Research topics are anticipated toinclude the following.
As future research areas, not only adverse economic effects and determinants of morbidity of circulatory
diseases but also the social significance of economic investment in health behaviors of therapeutic and preventive
interventions are expected to be extensively discussed topics. It is also critical to analyze regional medical systems
and welfare systems, which relate to the aforementioned economic effects and significance of economic investment,from the perspective of medical economics. Furthermore, it is highly likely that particular attention will be paid
to research on the management of medical institutions that support the healthcare system and to research on
behavior modifications (not only of patients but also healthcare providers).
Other highly interesting topics include economic evaluation of innovative medical technologies in the circulatory
field through clinical trials and distribution of medical resources based on other cost-effectiveness assessmentswith modeling estimates. In relation to these topics, it is also important to determine the effectiveness (orrestrictions) of medical treatment, including the measurement of therapeutic and preventive efficacy, frombroader and deeper perspectives than before. These topics require the development of a range of methodologies
for the calculation of utility value of patients and patient-reported outcomes (including patient’s quality of life,
functional status, and satisfaction with provided medical treatment), which are closely related to the evaluation
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4TAKURA Tof medical economics.
The healthcare system, per se, involves public aspects to a greater or lesser extent in any region of the world,
so significant progress in medical treatment in the circulatory field could be achieved through theory development,
empirical studies, and associated investigations of welfare economics verifying the validity of health policy. In
particular, there is a need for efficacy evaluation of various health policies and medical services, as well as
medical economic verification of the quality of medical services, against the background of discussions concerning
the supply and demand of medical services.
Lively and in-depth future-oriented discussions of these topics will facilitate the construction of valuableevidence that helps all personnel engaged in medical economics research (including members of the Japanese
Circulation Society) in not only gaining new insight into medical economics and but also enhancing their
explanatory power in propagating the significance of medical economics in the circulatory field. These approaches
will reinforce the foundation of medical economics research by economically supporting the advancement ofcirculatory science. Circulation Reports welcomes and encourages contributions from researchers in the circulatory
field who are studying medical economics with new discussion points, theories, and findings.
References
1. Takura T. An evaluation of clinical economics and cases of cost-effectiveness. Intern Med 2018; 57: 1191 – 1200.
2. PubMed. https://www.ncbi.nlm.nih.gov/pubmed (accessed May 20, 2018).
3. OECD (Organisation for Economic Co-operation and Development). https://www.globalnote.jp/post-15722.html (accessed May 20,2018).
4. Volpp KG, Konetzka RT, Zhu J, Parsons L, Peterson E; National Registry of Myocardial Infarction Investigators. Effect of cuts inMedicare reimbursement on process and outcome of care for acute myocardial infarction patients. Circulation 2005; 112: 2268 – 2275.
5. Martin S, Rice N, Smith PC. Does health care spending improve health outcomes? Evidence from English programme budgeting data.
J Health Econ 2008; 27: 826 – 842.
6. Castro-Palaganas E, Spitzer DL, Kabamalan MM, Sanchez MC, Caricativo R, Runnels V, et al. An examination of the causes,
consequences, and policy responses to the migration of highly trained health personnel from the Philippines: The high cost of living/leaving-a mixed method study. Hum Resour Health 2017; 15: 25.
7. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, et al; American Heart Association Council on Functional Genomicsand Translational Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Quality of Careand Outcomes Research, and Council on Epidemiology and Prevention. Future translational applications from the contemporary
genomics era: A scientific statement from the American Heart Association. Circulation 2015; 131: 1715 – 1736.
8. Cherry MG, Greenhalgh J, Osipenko L, Venkatachalam M, Boland A, Dundar Y, et al. The clinical effectiveness and cost-effectivenessof primary stroke prevention in children with sickle cell disease: A systematic review and economic evaluation. Health Technol Assess
2012; 16: 1 – 129.
9. Petrie J, Easton S, Naik V, Lockie C, Brett SJ, Stümpfle R. Hospital costs of out-of-hospital cardiac arrest patients treated in intensive
care: A single centre evaluation using the national tariff-based system. BMJ Open 2015; 5: e005797.
10. Heller DJ, Coxson PG, Penko J, Pletcher MJ, Goldman L, Odden MC, et al. Evaluating the impact and cost-effectiveness of statin use:
Guidelines for primary prevention of coronary heart disease and stroke. Circulation 2017; 136: 1087 – 1098.
11. Chang LL, DeVore AD, Granger BB, Eapen ZJ, Ariely D, Hernandez AF. Leveraging behavioral economics to improve heart failurecare and outcomes. Circulation 2017; 136: 765 – 772.

Tomoyuki Takura, PhD
Associate Editor
Circulation Reports

Circulation Reports Vol.0, July 2018