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Innocence [v 1.07 + DLC] Repack by xatab. Download A Plague Tale: Innocence [v 1.07 +DLC] Repack by xatab. ActionAdventure.Astrocytic reactivity during brain ischemia inhuman and rat. During the past decade, astrocytes have increasingly been recognized
as important actors in the brain response to injury, particularly in ischemia.
Numerous studies in animal models have revealed reactive morphological and molecularchanges in astrocytes, but definitive proof of their importance is still lacking inhumans. Therefore, this study investigated whether and to what extent astrocytes areactivated in the rat and human brain after middle cerebral artery occlusion (MCAO).
In two different experimental models of rat MCAO (60 or 90 min), astrocytic
activation was demonstrated by morphological changes and increased immunoreactivity
to the astrocyte-specific protein glial fibrillary acidic protein (GFAP). Incontrast, in a rat model of transient forebrain ischemia (20-min occlusion ofbilateral common carotid arteries), the number of GFAP-positive astrocytes did not
significantly differ from sham-operated controls. In the human brain, staining forthe astrocytic marker GFAP revealed few reactive astrocytes in the brain parenchyma
48-h postischemia, but numerous reactive astrocytes were observed within the penumbraof an infarct after 1 week. This increase in GFAP positivity was not significantly
different from that in rats, where astrocytic reactivity was highest 24-hpostischemia. These findings suggest that, in contrast to MCAO, ischemic brain

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