Day 2, Sunday, April 9
8:30 - 9:50

Room 1

Symposium 2：Recurrent Pregnancy Loss (RPL)
Chairs：Yasuhiko Ozaki
Clinical Department of Obstetrics and Gynecology, Nagoya City University West MedicalCenter
Yasuyuki Negishi
Department of Microbiology and Immunology, Nippon Medical School

S2-1

Autoantibodies against β2-glycoprotein I/HLA class II complexes is
associated with recurrent pregnancy loss
Kenji Tanimura
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine

S2-2

Decidual CXCR4+ CD56bright NK cells as a novel NK subset in maternalfetal immune tolerance to alleviate early pregnancy failure
Yanhong Li
Hospital of Obstetrics & Gynecology, Fudan University

S2-3

Pregnancy Outcome of Intravenous Immunoglobulin in women withRecurrent Pregnancy LossJaewon Han
Department of Obstetrics and Gynecology, College of Medicine, Konyang University

9:55 - 10:25

Educational Seminar
Sponsored by: GE Healthcare Japan Corporation
Nanosonics Japan K. k.
YAYOI Corporation
Chair：Hideaki Sawai
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

ES

Brain Asymmetry associated with Genetics
Ritsuko Kimata PoohFetal Diagnostic Center, Fetal Brain Center, CRIFM Prenatal Medical Clinic

10:25 - 10:40

Coffee Break: Outside Room 1 (301)

10:40 - 11:40

Special Lecture 4
Chair：Akitoshi Nakashima
Department of Obstetrics & Gynecology, University of Toyama

SL4

NK Cell and Pregnancy Immune Tolerance
Meirong Du [Video]
Obstetrics and Gynecology Hospital, Fudan University20

11:50 - 12:50

Luncheon Seminar 2：Repeated Implantation Failure
Sponsored by: Japan Society of Assisted Reproduction
Chair：Yoshiharu Morimoto
HORAC Grand Front Osaka Clinic

LS2-1

Clinical approach to recurrent implantation failure
Masahide Shiotani
Hanabusa Women's ClinicLS2-2

NK cell abnormalities and reproductive failures
Atsushi Fukui
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

12:55 - 14:15

Symposium 3：Premature Labor/Preeclampsia
Chairs：Takeshi Nagamatsu
Department of Obstetrics and Gynecology, International University of Health and Welfare
Narita Hospital
Katsuhiko Naruse
Department of Obstetrics and Gynecology, Dokkyo Medical University

S3-1

The regulatory mechanism of extravillous trophoblast invasion throughmicroRNAs
Hironori Takahashi
Department of Obstetrics and Gynecology Jichi Medical University

S3-2

Cervical remodeling in preterm laborJinying Yang
Department of Obstetrics, Longgang District Maternal & Child Healthcare Hospital of Shenzhen CityS3-3

Immune Regulation and Lymphatic Vessel Development in Severe
Preeclampsia
Yong-Sun Maeng
Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei
University College of Medicine

14:15 - 14:30

Coffee Break: Outside Room 1 (301)

14:30 - 15:10

Special Lecture 5
Chair：Toshiyuki Takeshita
Takeshita Ladies Clinic

SL5

Delivery of prostate cancer-associated non-coding RNAs within the bonemarrow milieu
Toshihiro Takizawa
Department of Molecular Medicine and Anatomy, Nippon Medical School21

15:10 - 16:10

Special Lecture 6
Chair：Hiroaki Shibahara
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

SL6

Endometrial gene expression and reproductive failures
Joanne Y.H. Kwak-Kim [Video]
Reproductive Medicine and Immunology, Chicago Medical School, Rosalind Franklin University ofMedicine and Science

16:10 - 16:15

22

Closing Remarks

Day 2, Sunday, April 9
8:30 - 9:06

Room 2

Outstanding Award 1
Chair：Mayumi Sugiura
Department of Obstetrics and Gynecology, Nagoya City University Graduate School ofMedicine

OA1-1

Withdrawn

OA1-2

Uterine endometrium microbiota and pregnancy outcome in womenwith recurrent pregnancy loss
Yutoku Shi
Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine

OA1-3

High 25-hydroxycholesterol induces apoptotic and ferroptotic cell deathby causing oxidative stress in trophoblast cells
Ki Mo Lee
Department of Obstetrics and Gynecology, College of Medicine, Konyang University Myunggok
Medical Research Institute

OA1-4

Alternative pathway specific complement regulator C1q/TNF-related
protein 6 is related the placental development and fetal growth
Ai Takeshita
Department of Anatomy and Neurobiology, Faculty of Medicine, Kindai University

9:06 - 9:54

Outstanding Award 2
Chair：Hidetaka Okada
Department of Obstetrics and Gynecology, Kansai Medical University

OA2-1

The effects of neonatal corticosterone administration on Sertoli cellnumber in the testes of mice in prepubertal and postpubertal stages
Hidenobu Miyaso
Department of Anatomy, Faculty of Medicine, School of Medicine, International University of Healthand Welfare

OA2-2

SCM-198 prevents endometriosis by reversing low autophagy ofendometrial stromal cell via balancing ERα and PR signals
Yikong LinGynecology and Obstetrics Hospital, Fudan UniversityOA2-3

Characterization of a spontaneously-occurring self-reactive antibody
against sperm in mice
Yuekun Chen
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

OA2-4

TULP2 deletion mice exhibit abnormal sperm flagellar structure andmale infertility
Yuki Oyama
Department of Experimental Genome Research, Osaka University

23

9:56 - 10:11

Award Ceremony

10:13 - 11:13

Oral 6：Endometriosis and Gynecological Cancer
Chair：Kei Kawana
Department of Medicine, Nihon University

O6-1

Inappropriate inflammation in ovarian endometrial cysts correlates withexcessive T-cell activation and increased level of high-mobility groupbox-1
Mariko Ikeda
Department of Obstetrics and Gynecology, Nippon Medical School

O6-2

Endometriotic cell-derived adenosine triphosphate (ATP) promotes thefibrosis of endometriotic lesions via eosinophil activation
Yosuke Ono
Department of Obstetrics and Gynecology, University of Yamanashi

O6-3

The role of p62, an autophagy-related protein, as a marker ofradiosensitivity in cervical cancer
Mihoko Yoshida
Department of Obstetrics and Gynecology, Toyama University, Toyama, Japan

O6-4

Cytonuclear estrogen receptor alpha regulates cell cycle andmitochondrial membrane potential of endometrial carcinoma cells
Zhong-Lian Li
Department of Anatomy, Tokyo Medical University

O6-5

Novel use of immune checkpoint inhibitors for vaginal melanoma:
A retrospective study
Kota Konishi
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University

11:13 - 11:37

Oral 7：COVID-19
Chair：Hiroyuki Tanaka
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

O7-1

Evaluation of protein expression and phosphorylation of SARS-CoV-2infected placental tissue in the second trimester by tandem mass tagsystem
Kazuhide Takada
Division of Microbiology, Department of Pathology and Microbiology, Nihon University School ofMedicine

O7-2

SARS-CoV-2 infection in pregnant female mouse featured as delayedanti-viral response
Lu LiuLaboratory for Reproductive Immunology, NHC Key Lab of Reproduction Regulation (Shanghai
Institute of Planned Parenthood Research), Shanghai Key Laboratory of Female Reproductive
Endocrine-Related Diseases, Hospital of Obstetrics and Gynecology, Shanghai Medical College,
Fudan University24

13:00 - 13:48

Oral 8：Sperm, Testis and Male Infertility-1
Chair：Akiko HasegawaDepartment of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

O8-1

Role of Calpain in Human Sperm for Fertilization
Yasuhiko Ozaki

Department of Obstetrics and Gynecology, Nagoya City University West Medical CenterO8-2

Detection of Sperm Antigens Corresponding to Sperm-Immobilizing
Antibodies in Infertile Women
Haruka Honda
Department of Obstetrics and Gynecology, School of Medicine, Hyogo Medical University

O8-3

Study of abnormal spermatogenesis in mouse model of Down syndrome
Tomohiko Wakayama

Department of Histology, Graduate School of Medical Sciences, Kumamoto University

O8-4Co-administration of the traditional medicines Hachimi-jio-gan andHochu-ekki-to can reverse busulfan-induced aspermatogenesis
Ning Qu
Tokai University School of Medicine, Tokyo Medical University

13:48 - 14:24

Oral 9：Sperm, Testis and Male Infertility-2
Chair：Masakatsu Fujinoki
Research Center for Laboratory Animals, Dokkyo Medical University

O9-1

ADAD2 functions in spermiogenesis and piRNA biogenesis in mice
Yonggang Lu

Immunology Frontier Research Center, Osaka University

O9-2

ERP2 is required for sperm motility and male fertility in male miceHsin-Yi Chang

Department of Experimental Genome Research, Research Institute for Microbial Diseases, OsakaUniversity

O9-3

GARIN2 is not essential for male fertility in mice
Haoting Wang

Graduate School of Pharmaceutical Sciences, Osaka University

14:24 - 15:00

Oral 10：Preterm Birth
Chair：Koichiro Shimoya
Department of Obstetrics and Gynecology, Kawasaki Medical School

O10-1

Role of immune cells in preterm birth induced by sterile inflammation
Yasuyuki Negishi

Department of Microbiology and Gynecology, Nippon Medical School25

O10-2Prophylactic treatment with progesterone prevents murine miscarriage
by suppressing the immunostimulatory activity of macrophage
Asane Iida
Department of Microbiology and Immunology, Nippon Medical SchoolO10-3Novel etiological analysis of preterm births related to innate immunityand sterile inflammation
Masahiko Kato
Department of Obstetrics and Gynecology, Nippon Medical School26