Name
Chikashi TERAO
Office Address
Laboratory for Statistical and Translational Genetics,
RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan
TEL:(+81) 45-503-9111
FAX:(+81) 45-503-9113
Email: chikashi.terao@riken.jp
cterao@u-shizuoka-ken.ac.jp
Date of Birth
26 October 1979
DegreeM.D., Ph.D.
Nationality
Japan
Education
2004

M.D.

Kyoto University, Kyoto, Japan

2011

Ph.D.

Kyoto University Graduate School of Medicine, Kyoto, Japan

Post Doctoral Training
2011-2014

Kyoto University Graduate School of Medicine, Kyoto, Japan (Dr. Matsuda) Brigham and2014-2017

Women’s Hospital, Harvard Medical School, Boston, MA, USA (Dr. Raychaudhuri)

Faculty Academic Appointments and Professional Positions
2011-2017

Assistant Professor, Kyoto University Graduate School of Medicine, Kyoto, Japan Senior2017-2018

Research Scientist, Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical
Sciences, Yokohama, Japan

2017-

Professor, The School of Pharmaceutical Sciences, University of Shizuoka, Japan

2018-2019

Deputy team leader, Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical
Sciences, Yokohama, Japan

2019-

Team leader, Laboratory for Statistical and Translational Genetics, RIKEN Center for
Integrative Medical Sciences, Yokohama, Japan

Appointments at Hospitals
2004-6 Resident, Shiga Medical Center for Adults, Shiga, Japan
2006-14 Attending Physician, Department of Rheumatology and Clinical Immunology, Kyoto University
Hospital, Kyoto, Japan
2008-2014 Attending Physician, Department of Rheumatology, Japanese Red Cross Wakayama Medical Center,
Japan
2017-

Chief in Immunology Research, Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan

Professional Certificate and activity
2007 Jul Board Certified Member of the Japanese Society of Internal Medicine
2012 Mar Japanese College of Rheumatology-board certified rheumatologist
2014 Apr Japanese College of Rheumatology Board of Councilors
2019 Apr Japanese College of Rheumatology-board certified rheumatologist instructor
2020 Mar

Fellow of the Japanese Society of Internal Medicine

Other Professional Positions
2005-6 Teaching Assistant, Department of Rheumatology and Clinical Immunology, Kyoto University Hospital,
Kyoto, Japan
2010-11 GCOE Associate Fellow, Department of Rheumatology and Clinical Immunology, Kyoto University
Hospital, Kyoto, Japan
Teaching and mentoring
Lecture for undergraduate students 2006-2010
Lecture for graduate students 2011, 2014
Yuji Narumiya (2011-12) Undergraduate student
Kosuke Tanaka (2013-14) Undergraduate student
Tanaka et al, J Hum Genet. 2014 (Publication#25)
Kazuya Setoh (2014-2015) Graduate student
Setoh et al, Nat Commun. 2015 (Publication#45)
Shuji Akizuki (2014~) Clinical scientist KAKENHI 16K09891
Akizuki et al, Ann Rheum Dis. 2018
(Publication#75) Ai Yaku (2015/4~) Graduate student
2016 The Kyoto University Foundation Travel Grant
Yaku et al, Sci Rep. 2017 (Publication#59)
Hideaki Tsuji (2015/4~) Graduate student
2016 The Kyoto University Foundation Travel Grant
2016 EULAR Travel Award
Tsuji et al, Sci Rep. 2017 (Publication#65)
Tsuji et al, Ann Rheum Dis. 2018 (Publication#72)

Ryosuke Hiwa (2015/4~) Graduate student
2016 JCR International Workshop Award
Hiwa et al, J Rheum. 2017 (Publication#68)
Nobuo Kuramoto (2015/4~2017) Assistant professor
2016 JCR International Workshop Award
2016 The Kyoto University Foundation Travel Grant
Kuramoto et al, Sci Rep. 2017 (Publication#66)
Yuki Ishikawa (2016/8~) Postdoctoral researcher
2018 EULAR travel award
2019 JCR International Workshop Award
Ishikawa et al, Semin Arth Rheum. 2019 (Publication#76)
Ishikawa et al, Ann Rheum Dis. 2019 (Publication#84)
Ishikawa et al, Mod Rheumatol 2019 (Review #8)
Ishikawa et al, Ann Rheum Dis. 2020 (Comments/Reply #1)
Ishikawa et al, Cells 2020 (Review #10)
Ishikawa et al, Journal of Scleroderma and Related Disorders (Review #11)
Hsing-Fan Lu (2018 Jul-2019 Mar) Graduate Student
Chief Ben-Eghan (2019 Jun-2019 Jul) Graduate student at McGil University
Nao Tanaka (2019 Apr~) Graduate Student
Nao Otomo (2019 May~) Graduate Student

Hiroyuki Suetsugu (2019 June~) Graduate Student Yoshinao Koike (2020 Jan~) Graduate Student
Shuji Ito (2020 Mar~) Graduate Student
Soichiro Yoshino (2020 Apr~) Graduate Student
Xiaoxi Liu (2019 Apr~2020 Mar) RIKEN International Program Associate(2020 Apr~) Research Scientist

Reviewer for Journals
Annals of Internal Medicine
Annals of the Rheumatic Diseases
Arthritis and Rheumatology (Arthritis and Rheumatism)
Autoantibodies
BMC Medicine
BMC Medical Genetics
BMJ Case Reports
Clinical Experimental Immunology
Clinical Rheumatology
Endocrine Journal
Expert Opinion On Drug Discovery
Heart Vessels
Hematologica
Human Immunology
Human Molecular Genetics
Hypertension
Immunology Letters
International Immunology
International Journal of Infectious Diseases
International Journal of Rheumatic Diseases
Journal of the European Academy of Dermatology and Venereology
Journal of Human Genetics
Journal of Investigating Dermatology
Journal of Genetics
Journal of Rheumatology
Medicine
Modern Rheumatology
Modern Rheumatology Case Reports
Nature Reviews Rheumatology
Patterns
Pharmacogenomics Journal
PLoS ONE
Rheumatology (Oxford)
Rheumatology International
Scandinavian Journal of Immunology
Science Advances
Scientific Reports
Reviewer for grants
British Heart Association Award (British Heart Association, UK)Honors and Awards
2009

GCOE Travel Award, Kyoto University
EULAR Travel Award, EULAR (European League Against Rheumatism) Congress 20092010

BD Japan Young Investigators’ Travel Award, 14th International Congress of Immunology

2011

Kyoto University Young Investigator Step-up Grant
GCOE Travel Award, Kyoto University
EULAR Travel Award, EULAR (European League Against Rheumatism) Congress 2011
EULAR Abstract Award, EULAR (European League Against Rheumatism) Congress 20112012

GCOE Travel Award, Kyoto University

2013

Japan Rheumatism Foundation Travel Grant
The Kyoto University Foundation Travel Grant
The Kato Memorial Trust for Nambyo ResearchMochida Memorial Foundation for Medical and Pharmaceutical Research Japan Intractable Diseases
Research Foundation
Japan Research Foundation for Clinical Pharmacology
Outstanding presenter award at the 41st Annual Meeting of the Japan Society for Crinical Immunology
Nagao Takeshi NANBYO Research Foundation

2014

JCR 2014 International Workshop Award
APLAR 2014 travel award
Japan Rheumatism Foundation
APLAR AbbVie Best Abstract Award at the 16th Asia Pacific League of Associations forRheumatology Congress
EULAR travel award, EULAR (European League Against Rheumatism) Congress 2014
The John Mung Advanced Program, Kyoto University
2015

Research Fellowship for study abroad, The Uehara Memorial Foundation
The 43rd KANAE Grant, The Kanae Foundation for the Promotion of Medical Science

2016

The Cardiovascular Research Fund, Tokyo, JapanEULAR travel award, EULAR (European League Against Rheumatism) Congress 2016
APLAR 2016 travel award
Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental University
Young Investigator Okamoto Award2017

JCR (Japan College of Rheumatology) Young InvestigatorAward Sakakibara Memorial Research Grant

Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental University
JSHG (Japan Society of Human Genetics) Young Investigator Award2018

Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental University
Shizuoka General Hospital Research Grant
RIKEN IMS Center Director’s Discretionary Budget

2019

The Young Scientists’ Prize, Ministry of Education, Culture, Sports, Science and Technology, Japan
Medical Research Encouragement Prize of The Japan Medical Association

2020

RIKEN Eihou award

Honors and Awards for junior researchers during mentorship 2016
JCR International Workshop Award (to Ryosuke Hiwa)
JCR International Workshop Award (to Nobuo Kuramoto)
EULAR travel award, EULAR (European League Against Rheumatism) Congress 2016 (to Hideaki Tsuji)
The Kyoto University Foundation Travel Grant (to Ai Yaku)
The Kyoto University Foundation Travel Grant (to Nobuo Kuramoto)
The Kyoto University Foundation Travel Grant (to Hideaki Tsuji)
2018

EULAR travel award, EULAR (European League Against Rheumatism) Congress 2018 (to Yuki Ishikawa)

2019

JCR International Workshop Award (to Yuki Ishikawa)

Funding Information
2011-2012

Genetic analysis of responsiveness to tocilizumab in rheumatoid arthritis
Kyoto University Young Investigator Step-up Grant
Role: PI
Annual Direct Cost: $13,500
The major goal of this study is to determine genetic variation associated with responsivenessto tocilizumab, humanized anti-IL-6 receptor antibody, in rheumatoid arthritis.
Completed

FY2013-FY2014 Integrative omics analysis for Takayasu arteritis
Grant-in-Aid for Young Scientists (B) from The Ministry of Education, Culture,
Sports, Science and Technology
Role: PI
Annual Direct Cost: $16,000
The major goal of this study is to detect critical gene, transcript, metabolite, protein,and pathway for the pathophysiology of Takayasu Arteritis.
Completed2013-2014

Elucidation of pathophysiology of systemic sclerosis by analyzing PLD4-mutant or KO mice
The Kato Memorial Trust for Nambyo Research
Role: PI
Annual Direct Cost: $20,000
The major goal of this study is to analyze fundamental mechanisms of systemic sclerosis byfocusing on novel susceptibility gene to SSc, PLD4. We will assess immunological change in
PLD4-mutant or –deficient mice.
Completed2013-2014

Multi-ethnic genome-wide association study for Takayasu arteritis Mochida Memorial
Foundation for Medical and Pharmaceutical Research
Role:PI
Annual Direct Cost: $30,000
The major goal of this study is to perform multi-ethnic genome-wide association study for
Takayasu arteritis to elucidate genetic background of Takayasu arteritis. We are planning toperform GWAS using Asian and Caucasian population.
Completed2013-2014

Functional analysis of susceptibility gene to Takayasu arteritis and develop novel therapy
for Takayasu arteritis
Japan Intractable Diseases Research Foundation
Role:PI
Annual Direct Cost: $20,000
The major goal of this study is to perform which genes of the susceptibility region on
chromosome 17 to Takayasu arteritis is responsible to the disease susceptibility and conduct
a clinical study to apply new therapy for this intractable disease based on GWAS results.
Completed2013-2015

Prospective study to prevent anti-thyroid drug-induced agranulocytosis in Graves’ disease
Japan Research Foundation for Clinical Pharmacology
Role:PI
Annual Direct Cost: $10,000
The major goal of this study is to develop algorithm to prevent anti-thyroid drug-induced
agranulocytosis in Graves’ disease based on genetic data and initiate a prospective study.
Completed2013-2014

Identifying susceptibility genes to connective tissue disease-associated pulmonary arterial
hypertension through multi-ethnic meta-analysis of systemic sclerosis Nagao Takeshi
NANBYO Research Fundation
Role:PI
Annual Direct Cost: $10,000
The major goal of this study is to determine susceptibility genes or variants to pulmonaryarterial hypertension in patients with connective tissue disease, especially systemicsclerosis by multi- ethnic meta-analysis of genome-wide association study.
Completed2014-2015

Investigation of clinical importance of IL12/23 in patients with Takayasu arteritis andfunctional analysis of variants in IL12B.
Japan Rheumatism Foundation
Role:PI
Annual Direct Cost: $10,000
The major goal of this study is to quantify levels of IL12 and IL23 in sera samples frompatients with Takayasu arteritis to determine which cytokine plays a critical role in
Takayasu arteritis and to analyze how variants in IL12B region contribute to basics in thisdisease.
Completed2016-2017

Investigation of gut microbiota in patients with Takayasu
arteritis The Cardiovascular Research Fund, Tokyo, Japan
Role:PI
Annual Direct Cost: $20,000
The major goal of this study is to analyze gut microbiota in patients with Takayasu arteritis
and show similarities of microbiota to patients with Inflammatory Bowel Disease especiallyulcerative colitis which frequently develops with Takayasu arteritis.
Current

FY2016-2017

Development of strategy to clarify pathophysiology of rare autoimmune diseases and lead tonovel treatment through genetic studies
Grant-in-Aid for Young Scientists (A) from The Ministry of Education, Culture, Sports,
Science and Technology/ JSPS KAKENHI Grant Number JP16H06251
Role: PI
Annual Direct Cost: $100,000
The major goal of this study is to clarify pathophysiology underlying rare autoimmune
diseases by mainly genetic studies and to identify critical molecules and pathways of thediseases to develop novel therapeutic strategy.

FY2016-2017

Why do patients with rheumatoid arthritis rarely develop DIP synovitis?
Grant-in-Aid for Challenging Exploratory Research from The Ministry of Education,
Culture, Sports, Science and Technology/ JSPS KAKENHI Grant Number
P16K15513
Role: PI
Annual Direct Cost: $17,000
The major goal of this study is to detect a mechanism underlying rheumatoid arthritis
which determines distribution of joint synovitis in rheumatoid arthritis.

FY2017-2018

Clarifying genetic similarities and differences between Takayasu arteritis and giant cellarteritis.
A Sakakibara Memorial Research Grant from The Japan Research Promotion Society for
Cardiovascular Diseases
Role: PI
Annual Direct Cost: $10,000
The major goal of this study is to analyze genetic characteristics of giant cell arteritis andcompare genetic components between Takayasu arteritis and giant cell arteritis.

FY2018-2018

Joint Usage/Research Program of Medical Research Institute Tokyo Medical and Dental
University
Role: PI
Annual Direct Cost: $4,000
The major goal of this study is to prioritize causal variants and functional annotations of
Takayasu arteritis based on GWAS results.

FY 2018-2018

Identifying subgroups among patients with SLE for personalized medicine
Shizuoka General Hospital Research Grant
Role: PI
Annual Direct Cost: $5,000
The major goal of this study is to determine subgroups among SLE patients based on genetics
and cellular populations in peripheral blood to provide the best treatment optimized for eachpatient.

FY 2018-2018

Functional analyses for genetic variants associated with autosomal mosaic events
RIKEN IMS Center Director’s Discretionary Budget
Role: PI
Annual Direct Cost: $20,000
The major goal of this study is to determine functional impact of genetic variants found to be
associated with autosomal mosaic events.

FY 2019-2019

Elucidating Japanese-specific genetic background of systemic sclerosis
Shizuoka General Hospital Research Grant
Role: PI
Annual Direct Cost: $5,000
The major goal of this study is to determine susceptibility among patients with systemicsclerosis based on genetics to find components specific to Japanese.

FY2019-2020

Identification of therapeutic targets for scleroderma-related pulmonary hypertension using
artificial intelligence.
Actelion research fundRole: PI

Annual Direct Cost: $10,000
The major goal of this study is to determine genetic determinants and therapeutic targets
using deep learning algorithm based on data of gene expression levels of patients withsystemic sclerosis with pulmonary hypertension.
FY2019-2020

Inference of sex differences in susceptibility to autoimmune diseases by focusing on clonal
hematopoiesis
Medical Research Encouragement Prize of The Japan Medical Association
Role: PI
Annual Direct Cost: $15,000
The major goal of this study is to determine genetic determinants and gene expression levels ofpatients with systemic sclerosis with pulmonary hypertension.

FY2020-2023

Elucidation for genetic regulation of enhancer expression and interpretation of geneticarchitecture in autoimmune diseases
Role: PI
Annual Direct Cost: $125,000
The major goal of this study is to sensitively quantify enhancer expression levels in LCL andcompare its genetic regulations across different populations to interpret genetic architecture in
autoimmune diseases.

Invited Presentations
2011 Sep 15‘Identification and functional analyses of susceptibility genes to rheumatoid arthritis’

Annual Congress of The Japan Society for Clinical Immunology (Tokyo, Japan)
2013 July 2‘How much do genetic component determine rheumatoid arthritis? –disease onset and its

disease phenotype’
The 34th Annual Meeting of the Japanese Society of Inflammation and Regeneration(Kyoto, Japan)
2013 Sep 28 ‘How much do genetic component determine rheumatoid arthritis? –disease onset and its
disease phenotype’
Kyoto Rheumatoid Arthritis Network Forum (Kyoto, Japan)
2013 Nov 16‘Combination of HLA-class I and II alleles confer exponential increase in the risk for

antithyroid drug-induced agranulocytosis.’
The 56th Annual Congress of The Japan Society for Thyroid Disease (Wakayama, Japan)
2014 July 17 ‘Disease and phenotype-related HLA alleles and amino acids’
Keiji Immunity Hematology Seminar (Kyoto Japan)

2014 Oct 30 ‘HLA region and HLA amino acids related to diseases and phenotypes in autoimmune diseases’
Keiji Immunity Hematology Seminar (Kyoto Japan)
2016 Sep 22 ‘Clarification of pathophysiology and identification of treatment target of Takayasu arteritis bygenetic studies.’Awardee Ceremony for Young Investigator Okamoto Award (Tokyo, Japan)
2017 Sep 16 ‘HLA-B position 9 is associated with a specific rheumatoid arthritis subset defined by noncanonical serologies’
The 16th Yotsuya Seminar for Rheumatic and connective tissue diseases (Tokyo, Japan)
2017 Oct 13 ‘Clarification of pathophysiology in rare autoimmune diseases through genetic approach’
JCR Basic Research Conference (Tokyo, Japan)
2017 Nov 17 ‘Clarification of pathophysiology in rare autoimmune diseases and development of newtreatment through genetic approach’
Awardee Ceremony for JSHG (Japan Society of Human Genetics) Young Investigator Award(Kobe, Japan)

2018 Jan 18 ‘Clarification of the basics of rheumatoid arthritis by cohort studies and database’The regular lecture series of Institute of Rheumatology, Tokyo Women’s Medical University (Tokyo Japan)
2018 April 26 ‘Clarification of pathophysiology in Takayasu arteritis through genetic and epidemiologicalanalyses’
Japanese College of Rheumatology (JCR) symposium (Tokyo Japan)
2018 Sep 1 ‘The Basics and application of genome-wide association study ~rheumatic diseases as an
example’Kyushu Japanese College of Rheumatology 2018 (Saga Japan)
2018 Sep 8 ‘A framework to conduct a genetic study in a rare disease for a novel treatment -an example of
Takayasu arteritis and beyond’
20th Asia Pacific League of Associations for Rheumatology Congress (Kaohsiung Taiwan)
2018 Sep 22 ‘HLA analysis and clarification of pathophysiology in Takayasu arteritis’The 27th Annual Meeting of the Japanese Society for Histocompatibility and Immunogenetics (Nagano
Japan)
2019 Feb 1st ‘Genetic components of onset and progression in rheumatoid arthritis’The 9th Special Advanced Rheumatology Forum for young doctors in Ehime (Matsuyama, Japan)
2019 Mar 14 ‘Genetic and epidemiological studies for clarification of pathophysiology in rheumatoid
arthritis –under the view point of clinicians-’ ORENCIA

Rising Seminar in Nihonbashi (Tokyo Japan)

2019 Apr 14 ‘Genetic studies and clinical application of rheumatic diseases’
Annual Course lecture, Japanese College of Rheumatology (JCR) symposium (Kyoto Japan)
2019 Apr 17 ‘Updates of genetic studies in rheumatoid arthritis’
Educational lecture, Japanese College of Rheumatology (JCR) symposium (Kyoto Japan)
2019 Jul 16 ‘Clarification of pathophysiology in Takayasu arteritis through genetic and epidemiologicalanalyses’
The 40th Annual Meeting of the Japanese Society of Inflammation and Regeneration (Kobe Japan)
2019 Aug 16 ‘Pathophysiology of rheumatoid arthritis-related autoantibodies’
RA Summer Seminar in Hiroshima (Hiroshima, Japan)
2019 Aug 25 ‘Genetic studies and clinical application of rheumatic diseases’
JCR2019 Annual Course Lecture in TOKYO (Tokyo Japan)
2019 Sep 6 ‘Elucidation of Biological Mechanisms in Rare Autoimmune Diseases Through Genetic Approach’
The 8th East Asian Group Of Rheumatology 2019 EAGOR (Seoul, Korea)
2019 Oct 8 ‘Somatic and germ line CNV in the Biobank Japan subjects’
SPHN (The Swiss Personalized Health Network) meeting (Tokyo)
2019 Oct 12 ‘Development of a new treatment option to Takayasu arteritis based on genetic andepidemiological findings’
IRA (Indian Rheumatology Association) Fellows Retreat 2019 (Vellore, India)
2019 Dec 8 ‘Genetic studies and clinical application of rheumatic diseases’
JCR2019 Annual Course Lecture in Osaka (Osaka Japan)
2020 Jan 22 ‘Construction and application of database for rheumatic diseases under the viewpoint ofphysician scientist’
The 10th Rheumatology Education Inter League REIL (Osaka Japan)

Presentations (as a presenter only)
2007 Apr 26‘Aeromonas hydrophila bacteremia after rituximab treatment in a patient with refractory

systemic lupus erythematosus’
The 51st Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Tokyo,
Japan) Oral presentation
2008 Apr 22‘Association between polymorphisms of TRAF1/C5 and rheumatoid arthritis in a Japanesepopulation’The 52nd Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology(Sapporo, Japan)
2008 Sep 20‘Association between HLA-DRB1 alleles and anti-CCP antibody in Japanese patients withrheumatoid arthritis’
Hiei RA forum (Kyoto, Japan) Oral presentation2009 Jun 11‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’European League Against Rheumatism (EULAR) Congress 2009 (Copenhagen, Denmark) Oral presentation2009 Sep 26‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’
Annual Congress of The Japan Society of Human Genentics (Tokyo, Japan) Oral presentation2009 Nov 1‘Identification of a novel genetic determinant of rheumatoid arthritis at chromosome 18q

by a genome-wide association study (GWAS) approach using large-scale Japanese cohorts’Kyoto University Global COE International symposium and retreat (Awaji, Japan) Oral presentation2010 Aug 25‘A genome-wide association study identifies myelin basic protein as a susceptibility gene torheumatoid arthritis in a Japanese population’
14th International Congress of Immunology (Kobe, Japan)
2011 May 27‘A HAPLOTYPE OF THE HUMAN AIRE GENE IS ASSOCIATED WITH THE RISK FOR

RHEUMATOID ARTHRITIS IN JAPANESE POPULATION’
European League Against Rheumatism (EULAR) Congress 2011 (London, UK) Oral presentation2011 Sep 9‘Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale

analysis for four years in Japanese’
Kyoto University Global COE International symposium and retreat (Awaji, Japan)
2011 Sep 15‘A Large-Scale Association Study Identified Multiple HLA-DRB1 Alleles Associated with

Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis in Japanese’
The 39th Annual Meeting of the Japan Society for Clinical Immunology (Tokyo, Japan)
2011 Nov 6‘A Large-Scale Association Study Identified Multiple HLA-DRB1 Alleles Associated with

Anti-Citrullinated Peptide Antibody Negative Rheumatoid Arthritis in Japanese’
Annual Congress of American College of Rheumatology (Chicago, USA)2011 Nov 28‘Serum IgG levels demonstrate seasonal change in connective tissue diseases: a large-scale

analysis for four years in Japanese’2011 Annual Meeting of the Japanese Society for Immunology (Chiba, Japan)
2012 Jun 9‘ACPA-NEGATIVE RHEUMATOID ARTHRITIS CONSISTS OF TWO GENETICALLYDISTINCT SUBSETS BASED ON RF POSITIVITY’
European League Against Rheumatism (EULAR) Congress 2012 (Berlin, Germany) Selected for one of theofficial poster tours
2012 Oct 25‘HLA region conferring levels of anti-nuclear antibody in a Japanese population’The 57th Annual Meeting of the Japan Society of Human Genentics (Tokyo, Japan) Oral presentation2012 Dec 6‘Three groups of joint synovitis in rheumatoid arthritis -analysis in KRAMAdatabase-’2012 Annual Meeting of the Japanese Society for Immunology (Makuhari Messe, Chiba, Japan)
2013 Apr 18‘Prevalence of anti-nuclear antibody and impacts of age and sex on the antibody levels in a

Japanese population -the Nagahama study.’
The 57th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Kyoto,
Japan) Oral presentation2013 Apr 20‘Three susceptibility amino acids to Takayasu arteritis in HLA-B protein.’

The 57th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Kyoto,
Japan) Oral presentation2013 Jun 13 ‘A NATIONWIDE STUDY OF SYSTEMIC LUPUS ERYTHEMATOSUS IN JAPANESEIDENTIFIED SUBGROUPS OF PATIENTS WITH CLEAR SIGNS/CLINICAL MARKER PATTERNS AND
FOUND THAT PARTICULAR SIGNS/CLINICAL MARKERS ARE ASSOCIATED WITH AGE AND/ORSEX’European League Against Rheumatism (EULAR) Congress 2013 (Madrid, Spain)2013 Oct 25‘Two novel susceptibility loci to Takayasu arteritis and synergistic role of the IL12B and

HLA-B regions in a Japanese population.’
ASHG (American Society of Human Genetics) 2013 Annual Meeting (Boston, USA)
2013 Nov 23‘Four polymorphisms in HLA-class I and II confer exponential increase in the risk for anti-

thyroid durg-induced agranulocytosis’
The 58th Annual Meeting of the Japan Society of Human Genentics (Sendai, Japan) Oral presentation2013 Nov 28‘Two novel susceptibility loci to Takayasu arteritis and synergistic role of the IL12B and

HLA-B regions in a Japanese population.’
The 41st Annual Meeting of the Japan Society for Clinical Immunology (Shimonoseki, Japan) Oralpresentation2014 Apr 4 ‘Heterogeneous characteristics of staining patterns among ANA’

16th Asia Pacific League of Associations for Rheumatology Congress (APLAR) (Cebu, Philippine) Oralpresentation2014 Apr 25 ‘The limited effects of smoking and shared epitope on the production of ACPA and RF in a
Japanese adult population: The Nagahama Study’
The 58th Annual General Assembly and Scientific Meeting of the Japanese College of Rheumatology (Tokyo,
Japan)
2014 June 12 ‘ANTI-CITRULLINATED PEPTIDE/PROTEIN ANTIBODY (ACPA)-NEGATIVE RA SHARESLARGE PROPORTION OF SUSCEPTIBILITY GENES WITH ACPA-POSITIVE RA.’
European League Against Rheumatism (EULAR) Congress 2014 (Paris, France)
2014 Nov 16 ‘Takayasu Arteritis and Ulcerative Colitis –High Concurrence Ratio and Genetic Overlap’
Annual Congress of American College of Rheumatology (Boston, USA)2014 Nov 22 ‘Ulcerative colitis is a major complication of Takayasu arteritis sharing genetic components
especially HLA-B*52:01’
The 59th Annual Meeting of the Japan Society of Human Genentics (Tokyo, Japan) Oral presentation
2015 Nov 9 ‘Rheumatoid Factor Is Associated with the Distribution of Hand Joint Destruction in a DoseDependent Manner’
Annual Congress of American College of Rheumatology (San Francisco, USA)2016 Jun 10 ‘FCGR2B AND MULTIPLE HLA LOCI ARE ASSOCIATED WITH SUSCEPTIBILITY TO
IGG4-RELATED DISEASE.’
European League Against Rheumatism (EULAR) Congress 2016 (London, United Kingdom) Oralpresentation
2016 Sep 28 ‘Genetic landscape of interactive effects of HLA-DRB1 alleles on susceptibility to rheumatoid
arthritis in the Japanese population’
Asia Pacific League Against Rheumatism (APLAR) Congress 2016 (China, Shanghai) Oral presentation
2016 Oct 19 ‘Specific rheumatoid arthritis antibody subphenotypes are associated with unique HLA-DRB1
residues at position 11’
ASHG (American Society of Human Genetics) 2016 Annual Meeting (Vancouver, Canada)
2016 Nov 16 ‘Specific Antibody Subphenotypes in Rheumatoid Arthritis Are Associated with Unique HLADRB1 Residues at Position 11’
Annual Congress of American College of Rheumatology (Washington DC, USA) Oral presentation2017 Feb 15‘Genome-wide association study revealed multiple associated loci with IgG4-related disease’

Third International Symposium on IgG4-RD and Fibrosis (Hawaii, USA) Oral presentation

2017 Jun 15‘TRANS-ETHNIC META-ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIESIDENTIFIES GSDMA AND PRDM1 AS SUSCEPTIBILITY GENES TO SYSTEMIC SCLEROSIS.’
European League Against Rheumatism (EULAR) Congress 2017 (Madrid, Spain) Selected for one of theofficial poster tours
2018 Oct 12‘Genetic landscape in mosaic events and their associations of hematopoietic malignancy andsurvival.’ Japanese Society of Human Genetics Congress 2018 (Yokohama, Japan) Oral presentation2018 Oct 17 ‘Mosaic events in 181,022 Japanese individuals provide novel molecular insights into clonal
hematopoiesis and hematopoietic malignancy’ ASHG (American Society of Human Genetics) 2018 Annual
Meeting (San Diego, USA) Selected edotor’s choice2018 Nov 9‘Identification of somatic mosaic events and their clinical significance in the Japanese

population’ The Japanese Society of Clinical Immunology Cogress 2018 (Nagano, Japan) Oral presentation
PatentUSE OF MYELIN BASIC PROTEIN AS A NOVEL GENETIC FACTOR FOR RHEUMATOID ARTHRITISWO Patent 2,012,144,512