ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧔ሶߤ߽ኅᐸ✚ว⎇ⓥ੐ᬺ㧕ಽᜂ⎇ⓥႎ๔ᦠಽᜂ⺖㗴㧦ਇ⢒∝ᖚ⠪ߩⴊዊ᧼ᯏ⢻ߩᬌ⸛ ࡟࡯ࠩ࡯ᢔੂ☸ሶ⸘᷹ᴺࠍ↪޿ߚᬌ⸛⎇ⓥಽᜂ⠪ ᧖ ବ㓉 ᧲ᶏᄢቇකቇㇱ↥ᇚੱ⑼㕖Ᏹൕᢎ᝼⎇ⓥⷐᣦ
᛫ RJQURJCVKF[NGVJCPQNCOKPG 2' ᛫૕߿╙ :++ ࿃ሶᰳਲ∝ߥߤ VJTQODQRJKNKC ߪਇ⢒∝‫ⴊޔ‬ᩖ∝ߩේ࿃ߣߥࠆߣ⠨߃ࠄࠇߡ߅ࠅ‫ߩߘޔ‬ᴦ≮ߣߒߡ᛫ⴊዊ᧼≮ᴺߢ޽ࠆૐ↪
㊂ࠕࠬࡇ࡝ࡦ≮ᴺ߇ᐢߊⴕࠊࠇߡ޿ࠆ߇‫ޔ‬ਇ⢒∝ᖚ⠪ߩⴊዊ᧼ᯏ⢻ߦ㑐ߔࠆᬌ⸛ߪ߶ߣࠎߤߥߐࠇߡ޿ߥ޿‫੹ޕ‬࿁ᚒ‫࡯ࠩ࡯࡟ޔߪޘ‬ᢔੂ☸ሶ⸘᷹ᴺࠍ↪޿ߡਇ⢒∝ᖚ⠪ߩⴊዊ᧼ಝ㓸⢻ࠍᬌ⸛ߒߚ‫࡯ࠩ࡯࡟ޕ‬ᢔੂ☸ሶ⸘᷹ᴺߦࠃࠆⴊዊ᧼ಝ㓸⢻ᬌᩏߪ‫ޔ‬ਇ⢒∝ߩ
TKUMHCEVQT ߩ∛ේᕈ⸃᣿ߦ᦭↪ߢ޽ࠆߩߺߥࠄߕ‫ޔ‬ਇ⢒∝ߩࠬࠢ࡝࡯࠾ࡦࠣᬌᩏߣߒߡ᦭↪ߢ޽ࠆߣᕁࠊࠇߚ‫ޕ‬㧭㧚⎇ⓥ⋡⊛ਇ⢒∝ߩේ࿃ߪ޿߹ߛਇ᣿ߩ੐߇ᄙߊ‫ࠇߎޔ‬߹ߢߩߣߎࠈਇ⢒∝଀ߦኻߔࠆࠬࠢ࡝࡯࠾ࡦࠣᴺ߿ᴦ≮ᴺߩ⏕┙ߦߪ⥋ߞߡ޿ߥ޿‫ޕ‬ᚒ‫ޘ‬ߪ ‫ ޔ‬ᣂ ߚ ߥ ਇ ⢒ ∝ ߩ risk factor ߣ ߒ ߡ ᛫
phosphatidylethanolamine (PE)᛫૕ߣ᛫╙ XII ࿃ሶ᛫૕ࠍᣢߦႎ๔ߒߡ߈ߚ߇‫⥄ߩࠄࠇߎޔ‬Ꮖ᛫૕߇ਇ⢒∝ߩේ࿃ߢ޽ࠆߩ߆ࠍ⸽᣿ߔࠆߚ߼ߦ‫∉ޔ‬ቇ⊛⎇ⓥߣᐔⴕߒߡၮ␆⊛⎇ⓥࠍᣉⴕߒߚ‫ޕ‬ਇ⢒∝ᖚ⠪ߩਛߢ‫ޔ‬᛫ 2' ᛫૕㓁ᕈ⠪ߩ⚂㧝㧛㧟ߦ╙ :++ ࿃ሶᵴᕈૐਅ߇޽ࠅ‫ߩߘޔ‬ᄙߊߪ᛫╙ :++ ࿃ሶ᛫૕ࠍᜬߟ੐ࠍᚒ‫ߪޘ‬ᣢߦႎ๔ߒߚ‫ޕ‬᛫ 2' ᛫૕㓁ᕈ⠪ߩਛߢ߽‫ ╙ޔ‬:++ ࿃ሶᵴᕈૐਅࠍ߽ߟ∝଀߇߽ߞߣ߽ᵹ↥₸߇㜞޿ߣ⠨߃ࠄࠇ‫ޔ‬᛫ 2' ᛫૕ߣ᛫╙ :++ ࿃ሶ᛫૕ߩ㑐ଥࠍㅊ᳞ߔࠆ੐߇ਇ⢒∝ߩ∛ේᕈ⸃᣿ߦ
㊀ⷐߣᕁࠊࠇࠆ‫ޕ‬᛫ 2' ᛫૕߿╙ :++ ࿃ሶᰳਲ∝ߥߤ VJTQODQRJKNKC ߪਇ⢒∝‫ⴊޔ‬ᩖ∝ߩේ࿃ߣߥࠆߣ⠨߃ࠄࠇߡ߅ࠅ‫ߩߘޔ‬ᴦ≮ߣߒߡ᛫ⴊዊ᧼≮ᴺߢ޽ࠆૐ↪㊂ࠕࠬࡇ࡝ࡦ≮ᴺ߇ᐢߊⴕࠊࠇߡ޿ࠆ߇‫ޔ‬ਇ⢒∝ᖚ⠪ߩⴊዊ᧼ᯏ⢻ߦ㑐ߔࠆᬌ⸛ߪ߶ߣࠎߤߥߐࠇߡ޿ߥ޿‫ޕ‬ᚒ‫ޔߪޘ‬᛫ 2' ᛫૕߇ KPXKVTQ ߢⴊዊ᧼ಝ㓸⢻ࠍ੣ㅴߐߖࠆߎߣߪᣢߦႎ๔ߒߚ߇ Thormb Res, 84,97, 1996)‫ޔ‬ᓥ᧪ߩ CIITGIQOGVGT ߢߪᗵᐲ߇ᖡߊ‫ޔ‬KPXKXQ ߩᄌൻࠍᝒ߃ࠆ੐߇࿎㔍ߢ޽ߞߚ‫ޕ‬㧮㧚⎇ⓥᣇᴺ੹࿁ᚒ‫߽ߩ࠻ࡦ࠮ࡦࠦ࠼ࡓ࡯ࠜࡈࡦࠗޔߪޘ‬ߣߢ࡟࡯ࠩ࡯ᢔੂ☸ሶ⸘᷹ᴺ㧔2#-19#㧕ࠍ↪޿ߡਇ⢒∝ᖚ⠪ߩⴊዊ᧼ಝ㓸⢻ࠍᬌ⸛ߒߚ‫࡯ࠩ࡯࡟ޕ‬ᢔੂ☸ሶ⸘᷹ᴺߪ‫࠻ࠗࠨ࡯ࡠࡈޔ‬ࡔ࡯࠲࡯ߦᔕ↪ߐࠇߡ޿ࠆᣇᴺߢ޽ࠅ‫ޔ‬ᓥ᧪ߩCIITGIQOGVGT ߩ  ୚ᗵᐲ߇⦟޿ߣߐࠇߡ޿ࠆ‫ޕ‬ᠣᜈߩߺߢ↢ߓࠆⴊዊ᧼ߩ⥄ὼಝ㓸ࠍᓥ᧪ߩ CIITGIQOGVGT ߢᬌ಴ߔࠆߎߣߪ߹ࠇߢ޽ࠆ߇‫ᧄޔ‬ᣇᴺߦࠃࠅᄙߊߩਇ⢒∝ᖚ⠪ߦ⥄ὼಝ㓸߇⷗޿಴ߐࠇߚ‫ޕ‬ᧄ⥃ᐥ∉ቇ⎇ⓥߪ‫∉ޟޔ‬ቇ⎇ⓥߦ㑐ߔࠆ୶ℂ
ᜰ㊎‫ߦޠ‬ၮߠߊ୶ℂ⊛ේೣࠍㆩ቞ߒߡታᣉߒߚ‫∉ޕ‬ቇ⎇ⓥߦ㑐ߔࠆ୶ℂᜰ㊎ߩ╙  ࠗࡦࡈࠜ࡯ࡓ࠼࡮ࠦࡦ࠮ࡦ࠻╬ߦࠃࠇ߫‫⎇ᧄޔ‬ⓥߪᣢሽ⾗ᢱߩߺࠍ↪޿ࠆⷰኤ⎇ⓥߦ⋧ᒰߔࠆߚ߼‫ޔ‬ญ㗡ߩߺߩหᗧߣߒߚ‫⎇ޔߚ߹ޕ‬ⓥࠍታᣉߒߡ
޿ࠆߎߣ࡮ౝኈ࡮ᣇᴺߥߤߦ㑐ߔࠆᖱႎࠍᐢႎ
ߒ㧔ࡐࠬ࠲࡯ߩ౏␜㧕‫⎇ޔߚ߹ޔ‬ⓥߦෳടߒߚ
ߊߥ޿႐วߦᜎุߢ߈ࠆᯏળࠍ⸳ߌߚ‫ޕ‬㧯㧚⎇ⓥ⚿ᨐ
ᚒ‫ߩੱ  ߪޘ‬ਇ⢒∝ᖚ⠪ߦኻߒߡ࡟࡯ࠩ࡯ᢔੂ☸ሶ⸘᷹ᴺࠍᣉⴕߒ‫ޔ‬VJTQODQRJKNKC ߣߩ㑐ଥࠍᬌ⸛ߒߚ‫ੱ ޕ‬ਛ‫⥄ޔ‬ὼಝ㓸ࠍ⹺߼ߚߩߪ  ੱ㧔㧕ߢ޽ߞߚ‫৻ޕ‬ᣇ‫ޔ‬ᱜᏱኻᾖ⟲ߢߪ  ੱਛ  ੱ  ߦ⥄ὼಝ㓸ࠍ⹺߼ߚ‫ޕ‬ߐࠄߦ‫⥄ޔ‬ὼಝ㓸ࠍਛ╬ᐲએ਄ߦ⹺߼ߚ  ੱߦߟ޿ߡᬌ⸛ߔࠆߣ‫ޔ‬᛫ 2' ᛫૕㓁ᕈߪ ‫ޔ‬╙ :++ ࿃ሶᰳਲߪ ߦ⹺߼ࠄࠇ‫⥄ޔ‬ὼಝ㓸ߩή޿⟲㧔ߘࠇߙࠇ‫ޔޔ‬㧕ߦᲧセߒߡ㜞₸ߢ޽ߞߚ‫৻ޕ‬ᣇߢ‫ ࡦࠗ࠹ࡠࡊޔ‬5 ᰳਲ‫ޔ‬᛫ࠞ࡞ࠫࠝ࡝ࡇࡦ᛫૕㓁ᕈߩ㗫ᐲߣ⥄ὼಝ㓸161ߩ᦭ήߣߩ㑆ߦߪ㑐ㅪࠍ⹺߼ߥ߆ߞߚ‫ޕ‬㧰㧚⠨ኤᚒ‫ޔߦߢߔߪޘ‬ਇ⢒∝ᖚ⠪ߩ߽ߟ᛫╙ :++ ࿃ሶ᛫૕ߩ 㧑߇╙ :++ ࿃ሶߩ JGCX[EJCKPߩ 0 ᧃ┵ߩࠕࡒࡁ㉄  ࠍ⹺⼂ߔࠆ੐ࠍႎ๔ߒ ߚ ‫ ߩ ߎ ޕ‬ㇱ ૏ ߪ ‫ ╙ ޔ‬:++ ࿃ ሶ ߩ ⴊ ዊ ᧼IN[EQRTQVGKP+Dǩ߳ߩ⚿วㇱ૏ߢ޽ࠆ‫ޕ‬㜞ಽሶࠠ࠾ࡁ࡯ࠥࡦߣ╙ :++ ࿃ሶߪ‫߽ࠄߜߤޔ‬IN[EQRTQVGKP+Dǩߩ⚦⢩ᄖࠨࡉ࡙࠾࠶࠻ߢ޽
ࠆ IN[EQECNKEKP ߦ┹ว⊛ߦ⚿วߒ‫ࡆࡦࡠ࠻ޔ‬ࡦߦࠃࠆⴊዊ᧼ᵴᕈൻࠍ㒖ኂߔࠆ੐߇ႎ๔ߐࠇߡ޿ࠆ‫ޔߡߞ߇ߚߒޕ‬᛫╙ :++ ࿃ሶ᛫૕ߪ‫ޔ‬╙ :++ ࿃ሶ߇ⴊዊ᧼ߩ )2+D+:8 ߦ⚿วߔࠆ੐ࠍ㒖ኂߒ‫ⴊޔ‬ᩖ߿ᵹ↥ࠍᒁ߈⿠ߎߒߡ޿ࠆน⢻ᕈ߇޽ࠆ‫ޔߦߺߥߜޕ‬㜞ಽሶࠠ࠾ࡁ࡯ࠥࡦߩⴊዊ᧼߳ߩ⚿วㇱ૏ߪ‫ࠗࡔ࠼ޔࡦࠥ࡯ࡁ࠾ࠠޔ‬ࡦ㧟ߩ %[U.[U %0# ߢ޽ࠅ‫ޔ‬᛫ 2'᛫૕ߩ⹺⼂ㇱ૏ߣห৻ߢ޽ࠆ੐߇ಽ߆ߞߡ޿ࠆ‫ ╙ޕ‬:++ ࿃ሶᰳਲਇ⢒∝ᖚ⠪ߩ 㧑ߦ᛫2' ᛫૕߇㓁ᕈߢ޽ࠅ‫ޔ‬᛫╙ :++ ࿃ሶ᛫૕ߣ᛫2' ᛫૕ߪ‫ޔ‬㕖Ᏹߦ㘃ૃߒߚ᛫૕ߢ޽ࠆ੐߇‫ޔ‬วᚑࡍࡊ࠴࠼ࠍ↪޿ߚᬌ⸛ߢಽ߆ߞߡ᧪ߡ޿ࠆ‫ޔߣࠆ߼ߣ߹ޕ‬ਇ⢒∝ᖚ⠪ߩᜬߟ╙ :++ ࿃ሶߣࠠ࠾ࡁ࡯ࠥࡦߦኻߔࠆ⥄Ꮖ᛫૕ߪ‫ ╙ޔ‬:++ ࿃ሶߣࠠ࠾ࡁ࡯ࠥࡦ߇ⴊዊ᧼ߩ )2+D+:8 ߦ⚿วߒߡ࠻ࡠࡦࡆࡦߦࠃࠆⴊዊ᧼ᵴᕈൻࠍ㒐ߋ੐ࠍ㒖ኂߒ‫ⴊޔ‬ᩖ߿ᵹ↥ࠍᒁ߈⿠ߎߒߡ޿ࠆน
⢻ᕈ߇޽ࠆ‫੹ޕ‬࿁‫ޔ‬ᚒ‫࡯ࠩ࡯࡟ޔߪޘ‬ᢔੂ☸ሶ
⸘᷹ᴺࠍ↪޿ߡਇ⢒∝ᖚ⠪ߩⴊዊ᧼ಝ㓸⢻ࠍ⺞ߴߚߣߎࠈ‫ޔ‬᛫ 2' ᛫૕㓁ᕈ㧗╙ :++ ࿃ሶᰳਲߩᖚ⠪ߢ੣ㅴ߇ߺࠄࠇ‫ߩࠄࠇߎޔ‬ᖚ⠪ߢ KP
XKXQ ߢ߽ⴊዊ᧼߇ᵴᕈൻߒߡ޿ࠆ੐߇␜ໂߐࠇߚ‫ޕ‬㧱㧚⚿⺰ਇ⢒∝ᖚ⠪ߩⴊዊ᧼ಝ㓸⢻ߪ KPXKXQ ߢ߽੣ㅴߒߡ޿ࠆ௑ะ߇␜ໂߐࠇߚ‫ޕ‬ਛߢ߽‫ޔ‬᛫ 2'᛫૕߅ࠃ߮╙ :++ ࿃ሶᰳਲߣ‫ⴊޔ‬ዊ᧼ಝ㓸⢻੣ㅴߣߩ㑆ߦ㑐ㅪ߇⹺߼ࠄࠇ‫ޔ‬ᚒ‫ ߩޘ‬KPXKVTQߢߪ᛫ 2' ᛫૕ߪⴊዊ᧼ಝ㓸⢻ࠍ੣ㅴߐߖࠆߣ޿߁࠺࡯࠲ࠍⵣઃߌࠆ⚿ᨐ߇ᓧࠄࠇߚ‫৻ޕ‬ᣇߢ᛫ࠞ࡞ࠫࠝ࡝ࡇࡦ᛫૕߿ࡊࡠ࠹ࠗࡦ 5 ᰳਲ∝ߪ‫ⴊޔ‬ዊ᧼ࠍ੺ߐߥ޿∛ේᕈ߇޽ࠆ੐߇␜ໂߐࠇߚ‫࡯ࠩ࡯࡟ޕ‬ᢔੂ☸ሶ⸘᷹ᴺߦࠃࠆⴊዊ᧼ಝ㓸⢻ᬌᩏߪ‫ޔ‬ਇ⢒∝ߩ TKUMHCEVQT ߩ∛ේᕈ⸃162᣿ߦ᦭↪ߢ޽ࠆߩߺߥࠄߕ‫ޔ‬ਇ⢒∝ߩࠬࠢ࡝࡯࠾ࡦࠣᬌᩏߣߒߡ᦭↪ߢ޽ࠆߣᕁࠊࠇߚ‫ޕ‬㧲㧚ஜᐽෂ㒾ᖱႎ  ߥߒ㧳㧚⎇ⓥ⊒⴫ ⺰ᢥ⊒⴫
5WIK 6 #WVQCPVKDQF[ CUUQEKCVGF
FKUTWRVKQPQHMCNNKMTGKPMKPKPU[UVGOKPRCVKGPVUYKVJTGEWTTGPVRTGIPCPE[NQUUGU
,RP,1DUVGV)[PGEQN0GQPCVCN*GOCVQN᧖ ବ㓉‫ޕ‬ਇ⢒∝ߣ⥄Ꮖ఺∉ᕈthrombophilia㧔᛫࡝ࡦ⢽⾰᛫૕‫ޔ‬᛫╙ XII࿃ሶ᛫૕‫ޔ‬᛫ࠠ࠾ࡁ࡯ࠥࡦ᛫૕㧕‫ⴊޕ‬ᩖᱛⴊ⹹; 20: 510-518, 2009.
᧖ ବ㓉‫ޕ‬᛫ phosphatidylethanolamine ᛫૕ߣ᛫╙ XII ࿃ሶ᛫૕‫ޕ‬කቇߩ޽ࠁߺ‫ޕ‬(in press)᧖ ବ㓉‫ޕ‬⠌ᘠᵹ↥ߣⴊᶧಝ࿕㒖ኂ⮎‫ޕ‬↥⑼ߣᇚੱ⑼‫(ޕ‬in press) ቇળ⊒⴫᧖ ବ㓉‫ޕ‬᛫૕ᬌᩏ‫≮ࡦ࡝ࡄࡋޔ‬ᴺ‫╙ޕ‬
117 ࿁ᣣᧄ↥⑼ᇚੱ⑼ቇળ㑐᧲ㅪว࿾ᣇㇱળ‫ޕ‬ㇺᏒ࠮ࡦ࠲࡯ࡎ࠹࡞‫ޕ‬2009‫ޕ‬㧔ࠪࡦࡐࠫ࠙ࡓ㧕᧖ ବ㓉‫ޕ‬ਇ⢒∝ᖚ⠪ߩⴊዊ᧼ಝ㓸⢻ߩ
ᬌ⸛—࡟࡯ࠩгᢔੂ☸ሶ⸘᷹ᴺࠍ↪޿ߚᬌ⸛—‫ ╙ޕ‬24 ࿁ᣣᧄ↢ᱺ఺∉ቇળ‫ޕ‬੩₺ࡊ࡜ࠩࡎ࠹࡞‫ޕ‬2009‫ޕ‬㧴㧚⍮⊛⽷↥ᮭߩ಴㗿࡮⊓㍳⁁ᴫ㧔੍ቯࠍ฽߻‫ޕ‬㧕 ․⸵ขᓧߥߒ ታ↪ᣂ᩺⊓㍳ߥߒ ߘߩઁߥߒ
⎇ⓥᚑᨐߩೀⴕߦ㑐ߔࠆ৻ⷩ⴫
㔀⹹⊒⴫⠪᳁ฬ

5WIK6᧖ ବ㓉

᧖ ବ㓉

᧖ ବ㓉

⺰ᢥ࠲ࠗ࠻࡞ฬ⊒⴫⹹ฬ

Autoantibody
associated disruption Jpn J Obstet
of kallikrein-kinin
Gynecolsystem in patients with Neonatal
recurrent pregnancy
Hematollosses.
ਇ⢒∝ߣ⥄Ꮖ఺∉ᕈthrombophilia㧔᛫࡝ࡦ⢽⾰᛫૕‫ޔ‬᛫╙XII࿃ሶ ⴊᩖᱛⴊ⹹᛫૕‫ޔ‬᛫ࠠ࠾ࡁ࡯ࠥࡦ᛫૕㧕᛫
phosphatidylethanolaකቇߩ޽ࠁߺ
mine᛫૕ߣ᛫╙XII࿃ሶ᛫૕⠌ᘠᵹ↥ߣⴊᶧಝ࿕㒖ኂ⮎↥⑼ߣᇚੱ⑼Ꮞภࡍ࡯ࠫ

಴ᐕ



KPRTGUU

KPRTGUU163