Preface
The Institute of Tropical Medicine, Nagasaki University, established in 1942, isa unique government-assisted institution for the research on tropical medicine, bothin the basic and applied fields. Its reorganization led to the first collaborative institute in medical science in Japan in 1989, and designation as one of the Centers of
Excellence in 1995 by Ministry of Education, Science and Culture. Present organization of the institute is composed of 3 major research fields (12 departments, 1 domestic visiting department, 1 overseas visiting department), 4 centers, and 1 clinical unit.
According to the first external review in 1996, the institute worked out its Mission Statement as shown on a back cover. To fulfil our mission, we continue the research and other related activities. The highlights are as follows.
＊Activities on the Mission Spear-head research in tropical medicine and international health
1. Strategic researches have been conducted to develop the novel weapon against tropical diseases; analysis of genomic structure of Japanese encephalitis and dengue viruses, structure and function of the receptors for bacterial enterotoxins, mechanisms for expression and activation of superoxide degenerating NADPH oxidase system, and immunogenetical analysis of tropical diseases.
2. Epidemiological studies and control have been carried out on malaria, dengue fever / dengue hemorrhagic fever,
SARS acute respiratory infections, Kaposi's sarcoma and schistosomiasis in Southeast Asia and Africa.
3. Environmental factors, such as vector and socio-economic problem, which cause the spread of tropical diseases inthe developing countries have been studied.
＊Activities on the Mission Global contribution through diseases control and health promotion in the tropics by applying
the fruits of the research
1. When the world was suffering from a severe outbreak of SARS in 2003, the institute dispatched 3 researchers to P.R.
China and other countries in respond to a request of WHO.
2. And in 2005, the institute dispatched the investigation team to make a survey of possible outbreak of infectious diseases in Indonesia and Sri Lanka, the countries that met disaster of tsunami.
Thus the staffs have given their technical co-operation to disease control program in developing countries as WHO
short-term consultants, JICA experts and other consultants.
＊Activities on the Mission Cultivation of the researchers and specialists in the above fields
1. Staffs of the institute conduct the doctorate and master degree course which belongs to Graduate School of Bio-medical Sciences in Nagasaki University. In 2006，a one-year course of the Master of Tropical Medicine opened for medical doctors.
2. Since 1978, the institute offers a 3-month course of Tropical Medicine and Related Studies.
3. Since 1983, the institute holds one year training course for foreign participants entitled Research in Tropical Medicine sponsored by JICA.
4. Since 2006, by the cooperation of WHO/TDR, the institute started Diploma Course on Research & Development of
Products to meet Public Health Needs (5 weeks) which 6 universities in 4 countries (Japan, Thailand, China, and Colombia) cooperated to held the course.
Based on the achievement mentioned above, in 1993，Department of Virology has been designated as WHO Collaborating Centre for Reference and Research on Tropical Viral Diseases, and since 2000 the Institute has played arole of core university in JSPS cooperative research program with Vietnam.
In 2003，Institute of Tropical Medicine and Graduate School of Biomedical Sciences made a joint application to the
21st Century Center of Excellence Program supported by Ministry of Education, Culture, Sports, Science and Technology. Our research program Global Control Strategy of Tropical and Emerging Infectious Diseases successfully obtains
a Governmet Grant of 5 years.
In 2005, the overseas research laboratories of the Institute of Tropical Medicine has been established in Kenya Medical Research Institute, Nairobi, Kenya and National Institute of Hygiene and Epidemidogy, Hanoi, Vietnam. The overseas research laboratories promise an extensive and longitudinal studies on tropical diseases.
In addition, the institute has a home page by which we appeal the public how tropical medicine is important for thewell being of humankind and offer the information on the tropical diseases.
This pamphlet is one of our advocacy efforts to the public. It offers a brief but intelligible explanation on our research activities and other related social activities. Any suggestions and supports will be gratefully appreciated.
August, 2008
Kenji Hirayama M. D., Ph. D.
Dean
Institute of Tropical Medicine
Nagasaki University

１

Contents
Preface ……………………………………………………………………………………………… 1
Contents …………………………………………………………………………………………… 2
Historical Review …………………………………………………………………………………… 3
Successive Deans of the Institute ………………………………………………………………… 4
Organizational Chart ……………………………………………………………………………… 5
Collaboration research …………………………………………………………………………… 6
Institute of Tropical Medicine Steering Committee ……………………………………………… 7
Institute of Tropical Medicine Collaboration Professional Committee …………………………… 8Character of research organization and activities ………………………………………………… 9
Postgraduate School ……………………………………………………………………………… 9Three-month Course on Tropical Medicine and Related Studies ………………………………… 9
Training Course in Research of Tropical Medicine ……………………………………………… 10
Public communication ……………………………………………………………………………… 10
Publications ………………………………………………………………………………………… 10
Global COE Program Integrafed Global Control Strategy for the Tropicaland Emerging Infectious Diseases ………………………………………………………………… 11
Department of Virology …………………………………………………………………………… 12
Department of Bacteriology ………………………………………………………………………… 13
Department of Protozoology ……………………………………………………………………… 14
Department of Parasitology ………………………………………………………………………… 15
Department of Clinical Medicine …………………………………………………………………… 16
Department of Host-Defense Biochemistry ………………………………………………………… 17
Department of Pathology …………………………………………………………………………… 18
Department of Preventive Medicine and AIDS Research ………………………………………… 19
Department of Eco-epidemiology …………………………………………………………………… 20
Department of International Health ………………………………………………………………… 21
Department of Global Health Development Policy Sciences …………………………………… 22
Department of Vector Ecology & Environment …………………………………………………… 23
Department of Immunogenetics …………………………………………………………………… 24Center for Infectious Disease Research in Asia and Africa○Kenya Research Station ……………………………………………………………………… 25○Vietnam Research Station …………………………………………………………………… 26○Fiji Research Station …………………………………………………………………………… 27
Tropical Medicine Museum ………………………………………………………………………… 28
Animal Research Center for Tropical Infections …………………………………………………… 29
Central Laboratory ………………………………………………………………………………… 29
Clinic at the University Hospital …………………………………………………………………… 30
Administration ……………………………………………………………………………………… 31
Number of Staff …………………………………………………………………………………… 31
Accounting ………………………………………………………………………………………… 31
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ………………………………………………………… 31
Grant-in-Aid for Scientific Research from the Ministry of Health,Labour and Welfare ………………………………………………………………………………… 32
Grant-in-Aid for Forming Research Locations etc (Global COE) ………………………………… 32
External Funding …………………………………………………………………………………… 32
Agreement of Educational, Scientific and Scholaly Exchange …………………………………… 32
Location map of the Institute of Tropical Medicine on Sakamoto Campusof Nagasaki University ……………………………………………………………………………… 33
Telephone Number ………………………………………………………………………………… 34

2

Department of Bacteriology and the Reference Center
were attached, and in 1978, the Department of Preventive Medicine, consisting mainly of visiting professors, associate professors, and researchers, and the Tropical
Medicine Training Course were launched. In the ensuing
year, the Infectious Animals Deprivation Experiment Laboratory was promoted to become the Animal researchCenter for Tropical Infections, and the second building expansion was concluded in March, 1980. In September,
1983, a JICA-sponsored group training program Tropical Medicine Research Course was opened, the Department of Protozoology was established a year after, andthe third building extension was finished in July the year
after that. Two years later, the Department of Medical Entomology was created and the Institute was reorganized
into the collaborative institute in another two years. In
1991, the Department of Biochemistry was added, andthe fourth building expansion was ended in March, 1994.
In April, 1994, the Institute was divided into three big Divisions, Tropical Microbiology, Pathogenesis and Clinical
Sciences, and Environmental Medicine, with the establishment of two new research Departments, Thermal
Adaptation and Social Environment, which have expanded to 12 Departments at present. The Institute was designated as Center of Excellence in the forefront of scientific research in 1995, and a new research Department,
Molecular Epidemiology, was established under the Research Field of Microbiology in 1996 to invite overseas
visiting professors. In 1997, the Reference Room for the
Tropical Medicine was replaced by the Tropical Disease
Information and Reference Center, and it was again succeeded by the Research Center for Tropical Infectious
Disease in 2001. In March, 2003, when the Sakamotobuilding finalized its fifth expansion, its extension work ofalmost 40 years came to an end. In March, 2006, themain building's repair work was completed. In April 2008,
the Research Center for Tropical Infectious Disease for
the Tropical Medicine was replaced by the Center for Infectious Disease Research in Asia and Africa and Tropical Medicine Museum.

Historical Review
The Institute of Tropical Medicine, Nagasaki University was originally founded in March 1942 as the East
Asia Research Institute of Endemics, Nagasaki Medical
College in order to perform basic and applied studies on
endemic diseases in East Asia. At the beginning, most of
its research activities were field studies conducted inmainland China by the Departments of Pathology, Bacteriology, Internal Medicine, and Dermatology of Nagasaki Medical College. August 9 th, 1945, the atomic bomb
was dropped in Nagasaki, and the Institute's all the facilities and research materials were completely destroyed together with Medical School. Consequently, the development of the Institute and its research activities had
lagged significantly behind.
In April, 1946, the Institute changed its name to the
Research Institute of Endemics, Nagasaki Medical College, and moved to Isahaya City in May to resume research activities. Yet in accordance with the National
School Establishment Law issued in May, 1949, the Institute once again changed its name to the Research Institute of Endemics, Nagasaki University. In 1957, the Institute was affected by another disaster of massive flooding,and its facilities, equipment, and research materials wereseverely damaged. Thus, construction of a new building
started in Sakamoto, Nagasaki City in 1960, and the Institute moved to the building in April of the following year.
The Institute's Departments, which were only two at thetime, Pathology and Clinics, increased its number every
year after 1963, including Epidemiology, Parasitology,
and Virology. The Sakamoto building finished its first expansion at the end of 1966.
In June, 1967, with the partial alteration of the National School Establishment Law, the name of the Institute was changed for the third time to the present one tocarry out basic and applied studies on tropical medicine.
Around the same time, the Department of Internal Medicine, Institute of Tropical Medicine, equipped with 20
beds, was opened in the University Hospital. In 1974, the3Successive Deans of the Institute（East Asian Research Institute of Endemics）
Susumu Tsunoo

May.4,1942 - Aug.22,1945

Kohei Koyano

Dec.22,1945 - Jan.23,1948

Kiyoshi Takase

Jan.24,1948 - Aug.31,1948

Noboru Tokura

Sept.1,1948 - May.30,1949（Research Institute of Endemics）
Noboru Tokura

May.31,1949 - Aug.31,1958

Nanzaburo Omori

Sept.1,1958 - Nov.30,1963

Hideo Fukumi

D e c . 1 , 1 9 6 3 - May.31,1967（Institute of Tropical Medicine）
Hideo Fukumi

June.1,1967 - Nov.30,1969

Daisuke Katamine

D e c . 1 , 1 9 6 9 - Nov.30,1973

Kaoru Hayashi

D e c . 1 , 1 9 7 3 - Nov.30,1977

Tatsuro Naito

D e c . 1 , 1 9 7 7 - Nov.30,1979

Daisuke Katamine

Dec.1,1979 - Apr.1,1981

Keizo MatsumotoA p r . 2 , 1 9 8 1 --A p r . 1 , 1 9 9 1

Hideyo Itakura

Apr.2,1991 - Apr.1,1993

Mitsuo Kosaka

Apr.2,1993 - Apr.1,1997

Akira Igarashi

A p r . 2 , 1 9 9 7 - May.31,2001

Yoshiki Aoki

A p r . 1 , 2 0 0 1 - May.31,2007

Kenji Hirayama

A p r . 1 , 2 0 0 7 - Up to the present
4Organizational Chart
Department of Virology
Department of Bacteriology
Microbiology
and Parasitology

Department of Protozoology
Department of Parasitology
Department of Molecular Epidemiology(Overseas Visiting Professor)

Department of Clinical Medicine
Host and Vector
Biology

Department of Host-Defense Biochemistry
Department of Pathology
Department of Preventive Medicine and AIDS Research
Department of Eco-epidemiology
Department of International HealthPublic andEnvironmental Health

Department of Global Health Development Policy Sciences
Department of Vector Ecology and Environment
Department of Immunogenetics

Dean
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station
Faculty
Meeting

Vietnam Research Station
Fiji Research Station
Animal Research Center for Tropical Infections
AssociatedFacilities

Tropical Medicine Museum
Central Laboratory
Office for Training and Education
General Affairs Unit

Administration

Accounting and Facilities Management Unit
Overseas Research Station Unit

University
Hospital

Clinical
Department

Department of Internal Medicine

5The senior staff composed of professors of the insti-

Collaboration researchtute and the executive committee make plans for researchwork. The steering committee and the collaboration profes-

The institute has conducted research in the field of

sional committee composed of experienced scientists coor-

tropical medicine for the past 65 years since its establish-

dinate the various collaboration researchs.
In the FY2007 a total of 12 selected projects and 5

ment in 1942. The institute was reorganized to make exten-

scientific meetings were carried out.

sive collaboration with other universities and institute in thefield of interdisciplinary tropical medicine with molecular biology, entomology, anthropology, social medicine, etc.
These activities of the institute are expected to contribute to remarkable progress of tropical medicine.

Collaboration Research Sytem

Steering Committee
The senior
staff

Collaboration professional
committee(Professors)

Executive committee

6

Institute of Tropical Medicine Steering Committee
Nagasaki University

Professor Emetitus

Akira Igarashi

Tayama Institute of HealthDirectorTakeshi KurataInternational Medical Center

President

Takehiko Sasazuki

Keio University School of Medicine

Professor

Tsutomu Takeuchi

Director

Narifumi Tachimoto

Research Institute for Humanity and Nature

Research Institute for Microbial Diseases Osaka University
Professor

Takeshi Honda

National Museum of Ethnology
Director−General

Makio Matsuzono

The Institute of Medical Science
The University of Tokyo

Director

Motoharu Seiki

Graduate School of Biomedical Sciences

Professor

Shigeru Katamine

Graduate School of Biomedical Sciences

Dean

Masao Tomonaga

Institute of Tropical Medicine

Dean◎ Kenji Hirayama〃

Professor

Kouich Morita〃

Professor

Toshiya Hirayama〃

Professor

Osamu Kaneko〃

Professor

Yoshiki Aoki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor

Masahiro Takagi〃

Professor

Tsutomu Mizota〃

Professor

Masaaki Shimada〃

Professor

Taro Yamamoto◎：Chairman

7Institute of Tropical
Medicine Collaboration Professional Committee
熱帯医学研究所運営委員会委員
The Institute of Medical Science The University of Tokyo
Professor

Aikichi Iwamoto

Meiji Gakuin University The Faculty of International Studies
Professor

Akira OkiProfessor

Kiyoshi Kita

Graduate School of Medicine The University of Tokyo
Graduate School of Veterinavy Medicine, Hokkaido University
Professor

Ikuo Takashima

Tsuda College Undergraduate Courses

Professor

Chizuru Misago

Kobe University Graduate School of Medicine

Professor

Haku Hotta

Research Institute for Humanity and Nature

Professor

Kenichi Abe

Nagasaki University

PegentKazumi Matsuoka

Graduate School of Biomedical Sciences

Professor

Isao Kouno

Institute of Tropical Medicine

Professor

Kouichi Morita〃

Professor

Toshiya Hirayama〃

Professor

Osamu Kaneko〃

Professor

Yoshiki Aoki〃

Professor

Koya Ariyoshi〃

Professor

Naoki Yamamoto〃

Professor◎ Masahiro Takagi〃

Professor

Tsutomu Mizota

〃

Dean

Kenji Hirayama〃

Professor

Masaaki Shimada〃

Professor

Taro Yamamoto◎：Chairman

8ing of four courses. All the departments in the Institutebelong to the Course of Infection Research. Students
who want to study tropical medicine in the Instituteare required to apply to the office of the Graduate
School of Biomedical Science through the professorof each department.
In addition to the PhD course, in 2006 Master ofTropical Medicine (MTM) course opened in the Nagasaki University graduate school of Biomedical Scienceand 12 students from various countries were admitted
to the school in April. The curriculum is constructed bythree parts namely (1) 4 months lecture and practiceon Clinical Trop Med and Tropical Public Health, (2) 1
month oversea training on tropical clinical medicine
and public health in Thailand, Vietnam and or Philippines, and (3) 6 months dissertation preparation foreach student's subject.
For the clinical training in the tropics, we set up 2
weeks training course at three affiliated hospitals,
Chianmai University Hospital, Thailand, Choray Hospital, Ho Chi Minh City, Vietnam, and San Lazaro Hospital, Manila, Philippines. The application from is available through our homepage. Briefly, the applicant
should have more than two years clinical training as a
medical doctor, and should have enough communication skill in English.
The Graduate School of International Health Development was founded at Nagasaki University in2008. Our main aim is to cultivate specialists who
contribute to the promotion of good health in developing countries. A Master of Public Health (M.P.H) degree is awarded to the students who successfully complete our two-year course of study. Since tropical
medicine plays a pivotal role in promoting good healthinternationally, three professors from Nagasaki University's Institute of Tropical Medicine serve as full-time
faculty in the M.P.H program.

Character of researchorganization and activities
Based on the following research organizationand intimate linkages with other research institutes
and universities, the institute aims at accomplishing a
mission Spear-head research in tropical medicine
and international health .
● To study comprehensively the tropical diseases
which are raging in the developing countries, research organization of the institute consists of 3 major research fields which deal with the classical triad of human-agent-environment determinants ofinfectious diseases and Overseas Research Station, Animal Research Center for Tropical Medicine, and Tropical Medicine Museum.
● The research of tropical medicine faces the inevitable fact that the bench is in the bush Therefore
the institute has a close linkage with the overseas
institutes in Asia, Africa and South Americas andcontinues the joint studies. Memorandums of academic exchange programs were signed between
Nagasaki University and 8 overseas institutes.
Since the overseas research laboratories of the institute has been established in Kenya Medical Research Institute, Kenya and National Institute of Hygiene and Epidemiology Vietnam in 2005, by the
grants from Ministry of Education, Sports, Culture,
Science and technology (MEXT), the extensive andlongitudinal studies on tropical diseases are on the
progress. The exchange program under the core
university system of JSPS established between our
Institute and National Institute of Hygiene and Epidemiology in Vietnam in 2000 has been renewed in2005 and lasts for 5 years more.
● The prevalence of tropical diseases depends onthe geographic, social and economic factors. Therefore the institute has established the special research system which helps forward the multidisciplinary studies on tropical diseases.

Three-month Course on Tropical
Medicine and Related Studies
This is the only one short-course of tropical medicine in Japan. This course aims to support medical
and paramedical personnel who are working or will
work in the tropics by providing opportunities to learna broad range of skills and knowledge relevant to practicing medicine, conducting disease control programs
and conducting medical research in tropical and developing countries.

Postgraduate School
In April, 2002, the system of Doctor Courses inNagasaki University has been changed. In the new
system the Graduate School of Medical Science, Dental Science and Pharmacology were integrated into
the Graduate School of Biomedical Science consist9

The course began in 1978. Up to the 30thcourse
held in 2007, 351 personnel (including 142 medical
doctors, and 209 paramedical such as nurses, community-health nurse, midwives, pharmacist) from allover Japan have completed the course. Fifteen participants are accepted to attend the course in each year.
The course is run by the steering committee, which
consists of members from both inside and outside theInstitute of Tropical Medicine (ITM).
The full-time staff member of the ITM and several
guest lecturers provide the 14 weeks (June to August)of lectures, laboratory practicals and field work in thefield of virology, bacteriology, protozoology, parasitology, medical entomology, environmental physiology, biochemistry, pathology, host-genetics, epidemiology,
human ecology, social medicine, clinical medicine andalso geography and culture in tropics. Participants
who completed the course successfully are awarded
the Diploma in Tropical Medicine.

knowledge and practical techniques for various medical problems in the tropics.
Individual participants will study on a selectedsubject in the responsible department for a year. Capacity of each department is normally limited to one
person.

Public Communication
Lectures and film shows for citizens are held occasionally. Every year, several groups of high school
students with teachers visit our museum, attending
lectures and film shows. To accumulate know-how ofrisk communication on tropical infectious diseases in
our institute, we are planning to introduce sciencecafe sessions where we have frank communication
with citizens on the present state and future prospectsof research on tropical medicine.

Publications
Our official publications are as follows;
１）Bulletin of Nagasaki University Institute of Tropical Medicine (in Japanese, yearly since 1964, PDF
files are available at our Web page.)２）English Brochure: INSTITUTE OF TROPICALMEDICINE NAGASAKI UNIVERSITY (this copy. yearly since 1977, PDF files are available at our Web
page.)
３）Japanese Brochure (in Japanese yearly since1977, PDF files are available at our Web page.)
４）Report of Nation-wide Cooperative Research Projects (Information of research activities and achievements as a nation-wile cooperative research centerfor tropical medicine is compiled.)５）Tropical Medicine (An academic Journal issued
since 1967 are now suspended since 2002．PDF
files are avairable at http://naosite. lb. nagasaki-u.
ac.jp/dspace/handle/10069/6. Electric files of Annals
of Endemic Diseases (in Japanese, 1959-1966, thepredecessor of Tropical Medicine) are also available
at the same Web page.)６）Special memorial volumes of the 20th, 30th and50th anniversary (in Japanesse)

Admission ceremony in 2007

Training Course in Researchof Tropical Medicine
Arrangements for conducting the course in this Institute are administered by Japan International Cooperation Agency, commissioned by the Government ofJapan to execute Technical Cooperation Programsfrom 1983.
This course is conducted by the Government ofJapan as a part of its Technical Cooperation Programs for developing countries with a view of contributing to upgrading their standards in tropical medicine
and to promoting friendly relations to the countries.
The purpose of this course is to help the control
of endemic and epidemic diseases infesting the Torrid
Zone. Through the guidance of the staff of the Institute, the participants will enrich their fundamental
10

skills to carry them out are absolutely necessary. This

Global COE Program
Integrafed Global Control Strategy for
the Tropical and Emerging Infectious Diseases
COE（平成15年度〜19年度）

new COE will focus onneglected infectious diseas-es (dengue fever, schistosomiasis, etc.) , which haverarely been considered because most of the cases
have been happened in poor developing countries,
plus diseases involving diarrhea, which tend to be

The United Nations issued eight development

treated as curable in developed countries. Of thesegoals in its Millennium Declaration in 2000 as interna-

tropical and emerging infectious diseases, we will lay

tional targets, with the core message being measuresconcepts of a new strategy in a comprehensive man-S-

ner to control and overcome those diseases which

top the occurrence of major diseases including

have currently become global issues or major impedi-

HIV/AIDS by 2015 and decrease the subsequent inci-ments to development, and work on research and de-dence rate.

The ultimate goal of this program is tovelopment of innovative technology essential for thecontrol and conquer these major infectious diseases.

implementation of our strategy. Moreover, throughWe will further advance and internationalize our out-

this process, we will foster promising experts who canstanding achievements in the 21st century COE pro-play a leading role in the future of this research area.

against infectious diseases expressed as follow:

gram to create a new center of excellence (COE) toward the accomplishment of these objectives.
For controlling and overcoming infectious diseases, tactical straegies and personnel with appropriate

11

on 23 Nov. 1993. In 2003, epidemiological and virological studies on SARS were added to its research activities. The Department was redesignated as a WHO
Collabrating Center for Reference and Research on
Tropical and Emerging Virus Diseases on 3 Feb.
2008 by Dr. Shigeru Omi, currently the Regional Director of WHO/WPR. The Department has received
WHO fellows from Vietnam, Fiji, and the Philippines,
and dispatched WHO short-term consultants on theactivities relevant to its terms of reference. Dr. Kouichi
Morita was dispatched to WHO/WPRO and was appointed as Reginonal Adviser on Communicable Diseases for the Western Pacific Region from 16 May
1995 to 15 May 1998. Dr. Futoshi Hasebe was dispatched to the WHO Western Pacific Regional Office
to collaborate in the global emerging infectious disease control program from March 2004 to March 2006.

Department of Virology
This Department has been conducting basic andapplied research on mosquito-borne flaviviral diseases such as Japanese encephalitis (JE), dengue fever(DF)/dengue hemorrhagic fever (DHF), as well as
SARS virus.
Analysis on the structure and function of JE and dengue viral genome
Nucleotide sequence analysis and molecular expression of JE and dengue viral genome have been
carried out together with long PCR techniques in order to study molecular epidemiology, epitope analysis, biological activity of nonstructural proteins, and virulent viral gene responsible for viral pathogenesis.
Analysis on apoptosis induced by flavivirus infections.

Professor and Head
Professor
Professor
Visiting Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Technician
Technician
Administrative Staff
Assistant
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Research Student

Flavivirus infection induces apoptosis of the infected cells. Characterization of apoptosis and its relation to pathogenecity has been studied in cell line andanimal model.
Development of rapid diagnosis of flaviviral diseases
Viral genome detection and identification by PCR
and LAMP methods, preparation of diagnostic antigen
from infected cell culture fluid, and simplification of
IgM antibody detection have been carried out.
Research on emerging viral infectious diseases
Studies on the development of diagnostic methods and epidemiology on SARS virus, Nipah virus
and H5N1avian influenza virus have been conductedin Viet Nam and other countries in the South East
Asia.
Activities as a WHO Collaborating Center
Dr. S. T. Han, former Regional Director of WHO
Western Pacific Region (WPR) designated the Department of Virology, Institute of Tropical Medicine, Nagasaki University as a WHO Collaborating Center for
Reference and Research on Tropical Viral Diseases

Newly identified JE neutralizing epitope 503

Kouichi Morita
Tetsu Yamashiro
Futoshi Hasebe
Maria del Carmen Parquet
Shingo Inoue
Toru Kubo
Yu Fuxum
Takashi Nabeshima
Genichiro Uechi
Kozue Hotta
Kazumi Jodai
Tomomi Yamaguchi
Melba Gidaya
Miki Masuda
Hitomi Kinoshita
Guillermo Posadas Herrera
Dinh Tuan Duc
Lyre Anni Espada Murao
Nguyen Dong Tu
Kenta Okamoto
Ryo Yoshikawa
Mya Myat Ngwe Tun

P3 level laboratory
12

logical responses of wild type and RPTPβ-deficient
mice to oral administration of VacA, we found that
RPTPβ functions as a receptor for VacA and produces the disease associated with VacA toxicity including gastritis and gastric ulcer [3]. Receptor-dependenttranslocation of VacA to lipid rafts is critical for signaling pathways leading to it's toxicity [8, 9, 10].
To know a potential mechanism of how H. pylori
establishes infection, we also investigate the hostparasite relationships of H. pylori, focusing on VacA as
well as CagA, which is an effecter protein injected by
its type IV secretion system into host cells. Consistent
with suppression of nuclear translocation of nuclear
factor of activated T cells, NFAT, in Jurkat T cells,
VacA counteracted CagA-induced activation of NFAT
in AGS cells, suggesting that the two major H. pylori
virulence factors inversely control NFAT activity [11].
Deregulation of NFAT, either positively or negatively,
may contribute to cellular dysfunctions that underlie diverged clinical manifestations caused by H. pylori infection.

Department of Bacteriology
Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria related to the worldwide emerging and reemerging diseases and to know the virulence mechanisms of bacterial pathogens.
１. Helicobacter pylori is a bacterial pathogen foundin the stomach mucosa of more than 50% of the world
population and more common (over 80%) in developing and tropical countries. Infection with H. pylori
plays a major role in the development of chronic gastritis and peptic ulcer, and is a risk factor for gastric cancer. Pathogenic strains of H. pylori secrete a potent
protein toxin, a vacuolating cytotoxin, termed VacA,
which causes progressive vacuolation of epithelial
cells and gastric injury. We found that VacA induces
multiple effects on epithelial cells, including mitochondrial damage [1] and apoptosis [2]. These actions of
VacA appear to result from activation of cellular pathways, independent of those leading to vacuolation.
Similarly, VacA-induced phosphorylation of G proteincoupled receptor kinase-interactor 1 (Git 1), which
may be responsible for epithelial cell detachment
caused by VacA, leading to peptic ulceration [3], and
VacA-induced activation of p 38/ATF-2- mediated signal pathway [4] are independent of VacA effects on
cellular vacuolation.
Analysis of VacA receptors provided new insights
into the molecular basis of VacA function. We reported that two VacA proteins, termed m 1 VacA and m 2
VacA, which were defined by sequence differences in
the middle of the molecules, interacted with target
cells by binding to two types of receptorlike protein tyrosine phosphatases (RPTPs), i. e., RPTPα andRPTPβ, resulting in toxin internalization and vacuolation of the human gastric adenocarcinoma cell lines
AZ-521 and G 401 [5, 6, 7]. By analysis of the patho-

References: [1] Microb. Pathog. 31:29-36, 2001, [2] J.
Biol. Chem. 281, 11250-11259, 2006, [3] Nat. Genet.
33:375-381, 2003, [4] J. Biol. Chem. 279, 7024-7028,
2004, [5] J. Biol. Chem. 278:19183-19189, 2003, [6]J. Biol. Chem. 279:51013-51021, 2004, [7] Cell Microbiol 7, 1285-293, 2005, [8] Infect Immun. 74, 6571-65
80, 2006,[9] Intect. Immun. 75:4472-4481, 2007, [10]J.
Immurol. 180:5017-5027, 2008, [11] Proc. Natl. Acad.
Sci. USA. 102, 9661- 9666, 2005.
Professor
Senior Assistant Professor
Assistant professor
Technologist
Technician
Postdoctral Fellow
Postgraduate Fellow

VacA

RPTP
RPTP
Lipid rafts

Internalizatio n

Vacuolatio n

Plasmamembran e
p38 activatio n

Inhibition of
p21 Expression

?

VacA
P

Activation ofBax and Bak

Activation of Calcineurin

Gastric ulcer

P

p38

P
NFATc3

NFATc3

Mitochondria lDamageP

ATF- 2Apoptosi s

CagA

Cell growt h

Nucleu s
p38

P

p21 WAF1/Cip 1
ATF- 2

p21

Malignantalteratio n

G1Arrest ofcells in
G1phaseCOX- 2COX- 2PGE2Cell growt h

Virulence mechanism of Helicobacter pylori vacuolating
cytotoxin, VacA.

Laboratory
13

Toshiya Hirayama
Akihiro Wada
Masahiko Ehara
Mamoru Iwami
Kayo Maeda
Masaaki Nakayama
Junzo Hisatsune

host

Department of Protozoology５）Epidemiology of the drug-resistant P. falciparum
malaria
６）Investigation of interactions between malaria par-Our goal is to clarify the infection mechanisms of
the intracellular protozoan pathogens, such as Plas-

asite species７）Prevelance, origins and population genetics of Af-

modium malaria parasites, Trypanosoma spp, andLeishmania donovani．

rican Plasmodium vivax

１．Malaria

２．Trypanosoma

１）Molecular basis of the erythrocyte invasion of the１）Functions and expression of transsialidase２）Adaptation mechanisms of Trypanosoma spp tomalaria merozoites
２）Molecular basis of the cytoadherence of the ma-environments
３）Modification of infected host-cells by Trypano- so-laria-infected erythrocytes
３）Searching the parasite antigens that are the hostma cruzi

immune target４）Survival strategies of the malaria parasites in the

３．Leishmania
１）Characterization of Leishmania donovani

Rhoptry Body
RhopH complex,RAP1,RAP2

RBC

Rhoptry Neck
RON2,RON4,RON5
Microneme
AMA1,EBA175,MTRAP
RH1,RH2,RH4２）Establishment of animal model of visceral leishmaniasis

Mz surface
MSP1,MSP2
P.V.
SERA,MSP3

Merozoite

iso-lates from Nepal

Dense Granule
RESA

Schematic of the malaria merozoite and its invasionrelated molecules.

Newly identified malaria proteins were localized to theapical end of the merozoites. Blue is parasite nucleous,green and red are the location of the identified proteins.
Upper panels are DIC images of the malaria parasite.

Professor

Osamu Kaneko

Senior Assistant Professor

Haruki Uemura

Assistant Professor

Shusuke Nakazawa

Assistant Professor

Kazuhide Yahata

Assistant Professor

Richard Culleton

Assistant

Miki Kinoshita

Graduate Student

Akikocristina Salati

Graduate Student

Yoko Tsumori

Graduate Student

Morakot Kaewthamasorn

Research Fellow

Jianxia Tang

Assistant

Xiaotong Zhu

Amastigotes (left) and trypomastigotes (right) of
Trypanosoma cruzi.
14the laboratory. Highlights of recent studies are as follows.
１）Swimming behavior of miracidia:
cAMP is involved in the control of ciliary beating
and chemotaxis of miracidia, and the vigorous swimming of miracidia inside the egg-shell is a key factor
for hatching of miracidia.
２）Mechanisms of penetration of cercariae into skin:
The studies suggest the involvement of protein
kinase C in proteolytic enzyme release from cercariae.
３）Epidemiology and control of S. haematobium infection:
Since 1981, the research project on Schistosomiasis haematobia was carried out in Kwale, Kenya,in cooperation with KEMRI for 25 years. The highlights of our studies are human water contact study,
cercarial concentration in natural water, ecology of Bulinus globosus, usefulness of urinary reagent strips,
new immunodiagnostic test (urine ELISA, modified
COPT), effect of piped water supply, KAP study(knowledge, attitude and practices), health education,
morbidity studies using ultrasound, environmental
modification for snail control, prevalence of bladdercancer and liver fibrosis, and qualitative and quantitative studies on difficulty of urination in the community.
４）A novel tool for control of schistosomiasis, Decoy
snails: Schistosome miracidia invade nonintermediatesnails too. Presence of the huge number of decoysnails that attract powerfully miracidia, but do not allow miracidia to develop, is expected to block the life
cycle of schistosome. The studies on decoy snails arecarried on.

Department of Parasitology
The research activities are concentrated on filariasis and schistosomiasis which constitute the major
public health problems in the tropics.
Filariasis
Brugia malayi (Cheju strain, periodic form) , B. pahangi and the vector mosquito, Aedes aegypti (Liverpool strain) have been maintained in the laboratory formany years. Highlights of recent studies are as follows.
１）Development of a simple and sensitive methodfor determination of serum concentration of ivermectin(IVM) and diethylcarbamazine (DEC) :IVM and DEC modified partially in their chemical
structure successfully produced the antibody against
drugs. Therefore the serum concentration (5ng/ml) of
IVM and DEC can be determined by EIA.
２）Screening of antifilarial drugs from medical plants:
Vernonia amygdalina from Africa, Neurolaena lobata from Guatemala and Cardiospermun halicacabum from Thailand, were effective in vitro on B. pahangi adult worms and microfilariae.
３）Epidemiology and control of bancroftian filariasis:
A research project was carried in Kwale, Kenya,in cooperation with Kenya Medical Research Institute(KEMRI) during the period of 1990 and 1996. Transmission potential and morbidity were studied. Masschemotherapy with combination of DEC and NaHCO3
was evalualed.
４）Chemotaxis of filarial infective larvae:
We first reported B pahangi infective larvae show
chemotaxis to serum. The peculiar chemotactic movement and the signal transudation involved in chemotactic response were also reported. Serum factorsthat cause chemotactic response of larvae are investigated.

Professor
Assistant Professor
Assistant Professor
Technologist
Technician
Technician
Postgraduate Student
Postgraduate Student

Schistosomiasis
Schistosoma mansoni (Puerto Rican strain and
Kenyan strain), S. haematobium (Kenyan strain)andsome strain of vector snails have been maintained in

Yoshiki Aoki
Kanji Watanabe
Yoshinori Mitsui
Mitsumasa Miura
Satomi Tominaga
Masako Hayashida
Tomoharu Ohki
Mayumi Abe

A square glass capillary（13×1.5×1.2mm）

Inoculation ofsnail-conditioned water（0.5μl)＊＊＊

Accumulation of miracidia at the first fourth（＊）and the first half（＊＊）of the tube.

Examination of difficulty of urination by using Uroflowmeterin an endemic area of Kenya

Observation of the snail-conditioned water that has attraction
for schistosome miracidia
151000 cases have been registered and we are currently analyzing clinical samples and data.

Department of Clinical Medicine

3.HIV cohort studies in northern Thailand
In collaboration with National Institute of Health,Thailand and National Institute of Infectious diseases,
Japan, a large scale of cohort study targeting HIV-infected individuals and their spouses has been established and maintained in Lampang Hospital, northern
Thailand. So far, over 1200 people have participated.
The main objectives of this cohort are to understandmechanisms of resistance to HIV infection among
HIV-exposed but uninfected spouses living with HIVinfected patients and mechanisms of slow-progression among HIV-infected slowprogressors. Thesestudies are being conducted in close collaboration
with Thai counter parts and international experts invarious fields such as hostgene polymorphisms, molecular immunology, molecular epidemiology and virology. Furthermore, based on this field setting, we arealso conducting studies on frequencies of opportunistic infection, the effect of anti-retroviral drug therapy,
and social need for children born to HIV-affected parents.

Main objectives of research activities in the Department of Internal Medicine are to understand pathogenesis of tropical diseases and respiratory infectious
diseases and to improve diagnosis, prevention andtherapy for infectious diseases in developing countries. Various basic scientific research and international collaborative studies are on going as follows:
1.Respiratory Infections
Our goal is to better-understand mechanisms
causing severe and treatment-refractory pneumonias
at molecular levels toward development of a novel
treatment strategy. We hypothesize that patients withsevere and treatment-refractory pneumonia has an impaired process in inducing the cessation of inflammation and re-construction of damaged tissues. We, particularly, focus on the function of macrophage which is
responsible for clearing apoptotic cells from the inflammation site using a mouse pneumonia model. We
have also developing a rapid and comprehensive assay to identify multiple pathogens causing respiratory
infections, which is being applied for several clinicalstudies.

Department of Clinical Medicine
Professor
Professor (Project)
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Technician
Technician
Secretary
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student
Postgraduate student

2.Pediatric Infectious Diseases in Vietnam
We have, so far, conducted studies on clinicaland bacteriological diagnosis, antimicrobial susceptibility and molecular epidemiology in collaboration with
National Institute of Hygiene and Epidemiology. Since
2005, we further collaborated with International Vaccine Institute and started a large-scale of census survey targeting all residents in Nha Trang city and its adjacent Nin Hoa district in the middle part of Vietnam.
During the census, we also collect information regarding environment and diseases burden (particularly
pneumona, diarrhea, dengue fever), health utilization
pattern. Since 2006, a research clinician has been dispatched from our department and monitoring all pneumonia cases admitted to the pediatric ward at Kan
Hoa General Hospital in the above city. So far over

Khanh Hoa General Hospital (Vietnam)

Koya Ariyoshi
Hideki Yanai
Konosuke Morimoto
Kei Miyagi
Laymyint Yoshida
Motoi Suzuki
Mitsuyo Kirie
Rina Shiramizu
Rika Nogawa
Naho Tsuchiya
Vu Thi Thu Huong
Masahiko Mori
Takayuki OikeToshitaka Sukizaki
Yoshiyasu Yoza
Keita OmaP2 Level Laboratory16

nated portions of DNA would be more important in

Department of Host-Defense Biochemistry

tropical area than other areas. Transitions appreciably
occured more at TRTRNB sites than at other sites inReserches in our laboratory are focused on thetumor supressor protein p 53 exons, suggesting thismolecular regulations of the phagocyte NADPH oxi-

particular sites were fragile in tumor-prone cells. Rela-dase system that generates active oxygens essential

tive frequency of esophageal cancer due to transitionsfor killing invading microbes.

at p 53 non-GpG sites in Brazilian mate-drinkers was
relatively higher than that in world-wide patients.

Selective expression mechaisms for gp 91phox, a core

Cloning and purification of this nGTBP are now urgent

component of the oxidase

issues in our laboraatory.

The phagocyte NADPH oxidase is composed ofmembrane-integrated flavocytochrome b 558 contain-

Visiting Professor

Tomoyuki Maekawa

ing gp 91phox and p 22phox, and cytosolic components

Associate Professor

Futoshi Kuribayashi. Upon phagocytotic stimu-

Assistant Professor

Yoshito Fujii

lation, cytosolic factors move to membrane to makeTechnical AssistantChikako Arakisuch as p 47

phox

and p 67phox

an active complex with the flavocytochrome. Basedon genetic analysis of CYBB, the gene encoding gp
91phox, in a patient with chronic granulomatous disease(CGD), we found that PU.1, a transcriptional activator,
bound to gp 91phox promoter position centered to bp-53 was important for the expression of gp 91phox inneutrophils, monocytes, and B lymphocytes, but not in
eosinophils. On the other hand, GATA-1 bound to a
position centered to bp -98 had an important role in
the expression of the gene in eosinophils.
Analysis of NADPH oxidase
We are receiving blood samples to check whether the patients are CGD or not by testing genomic
DNA and protein. And also we check mRNA to detect
the length because there are skipping mechanisms to
avoid pre-mature stop.
A novel GT-mismatch binidng protein
In the analysis of a cis -element of gp 91phox promoter, we found a novel GT-mismatched DNA binding
protein. An addition of unlabelled competitor homoduplex with G/C at bp -177, generated, but not erased, astrongsupershifted' band in EMSA using the label-

led probe with A/T at bp -177. Newly paired heteroduplex with the unlabelled upper stand with G at bp -177
and the labelled lower stand with T at the same position recruited nGTBP. This protein strictly required
TRTGNB (R=purine, N=any base, B=not adenine, G
paired with T) and 14-mer or longer for binding. G canbe replaced by deaminated A, namely, hypoxanthine,suggesting deaminated C-6 is essential for nGTBP
binding. Deamination of nucleotide bases are increased by high temperature and the repair of deami17

mation include the predominance of lymphocytes andmacrophages. In 1863, Virchow hypothesized that malignant tumors occurred in the chronic inflammation lesions associated with lymphocyte infiltration. Activated lymphocytes and macrophages are interactive in
releasing inflammatory mediators such as cytokines,
chemokines, growth factors, and survival factors interact with specific cell surface receptors resulting in amplified immune reactivity.
The mechanisms of oncogenesis associated with
infection and inflammation have not been elucidated.
However, many oncogenic mechanisms have been
proposed for infection and inflammation; for example,
1) Signal transduction: Toll-like receptors (TLR) for
pro-inflammatory cytokins, such as tumor necrosis factor-α(TNF-α) and interleukin-1 (IL-1), IL-6, IL-8, andIL-18 leads to activation of many important signaling
pathways. The other pro-inflammatory gene products
are matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), cyclooxygenase-2(COX-2), and 5-lipoxygenase (5-LOX). It is well accepted that the NF-κB group of transcription factors
play a still more important role in inflammation. 2) Direct action of viral proteins and host cells: Products ofbinding viral proteins and human genes lead to alteration of host cells. Tumor-suppressor gene products ofretinoblastoma protein (pRb) and p53 are inactivatedby interaction with products of viral proteins. For example, human papillomavirus (HPV) E6 and E7 proteins
are oncogenic factors in HPV related cancers. 3) Immunosuppression: Human immunodeficiency virus(HIV) causes immunosuppression, which leads to Kaposi's sarcoma and/or malignant lymphomas. 4) Production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Prolonged activation of
inflammatory cells generates ROS and RNS that candamage host DNA, which can contribute to carcinogenesis. Activation of NF-κB is also involved cancer
development and progression. Therefore, our research focuses on the molecular players during thedevelopment from chronic inflammation to cancer.

Department of Pathology
Main purpose of our research is fundamentally
pathological investigation of tropical diseases, mainly
infectious diseases, focused on oncogenic microbes,
and establishes the basis of their treatment and prevention. Although many investigators have proposed
oncogenesis due to inflammation associated cancer
development, the mechanisms underlying the relationship between chronic inflammation and cancer still remain unresolved. Therefore, our research focuses on
the potential role of oncogenic microbes in the development of cancers, highlighting the recent advancesin the understanding of the molecular mechanisms.
Inflammation and cancer
The proportion of total cancer deaths attributable
to infectious agents is estimated to be 20% to 25% indeveloping countries and 7% to 10% in industrializedcountries. A causal relationship between chronic inflammation and cancer is widely accepted. Specifically, there is a strong association between tumor viruses and the development of human cancers. Both DNA
and RNA viruses have been reported to be capable ofcausing cancer. Epstein-Barr virus (EBV), human papillomavirus (HPV), hepatitis B virus (HBV), and Kaposi's sarcoma associated herpesvirus (KSHV) are DNA
viruses known to lead to the development of cancers.
Cancer inducing RNA viruses include Hepatitis C virus (HCV) and human T lymphotropic virus type-1(HTLV-1). EBV is associated with Burkitt's lymphoma,
nasopharyngeal carcinoma, Hodgkin's lymphoma andnon-Hodgkin's lymphoma; HBV and HCV viruses with
hepatocellular carcinoma; HTLV-1 with adult T-cell leukemia/lymphoma; and HPV with cervical cancer, penile cancer, anal cancer, oropharyngeal cancer, andskin cancer. In developing countries, 15% to 20% of
the global cancer burden can be linked to these infections. An additional 5% can be attributed to bacterial
infection (Helicobacto pylori) and parasitic infections(Schistosoma, Opistorchis, Clonorchis).
Histopathological characteristics of chronic inflam-

Assistant Professor
Postgraduate Student

18

Senba Masachika
Sumiko Irie

actin.We try to identify the cellular molecule thatfunctions as a linker between the receptor and actin.

Department of Preventive
Medicine and AIDS Research

Application of HIV envelope gene to gene therapy
HIV enters into target cells by fusion between
virus envelope and cell membrane. This reaction iscatalyzed by envelope glycoprotein encoded by theviral genome. When the envelope gene is introduced to susceptible cells expressing CD4 andCXCR4, syncytium formation is induced by its membrane fusion activity, and die. Recently, CD4-independent HIV has been isolated. When the envelope gene of the CD4-independent HIV is
introduced to cells expressing CXCR4 but not CD4,syncytium and cell death was induced. It has beenreported that CXCR4 is up-regulated in mammary
tumor. This suggests that the CD4-independent
HIV envelope protein specifically induces cell deathof mammary tumor cells. We are studying the application of the CD4-independent HIV envelope as anovel therapeutic gene for mammary tumor.

This department was newly added to the institute in 1978 as a research division open to visiting
professors from other universities and institutes. It
is run by concurrent research staff for the present.We have planned and started from August of
2002 a series of fundamental research to answer
the question how and what mechanisms human immunodeficiency virus and murine leukemia virus enter into host cells. In addition, we are studying theapplication of these retrovirus to human gene therapy.
Study on the mechamism of viral entry into host cellsby retroviruses
Human immunodeficiency virus (HIV) is known
to be a causative agent for acquired immunodeficiency syndrome. After the HIV recognizes CD4and chemokine receptor, for example CXCR4, it enters into target cells mediated fusion between virus
envelope and cell membrane. Murine leukemia virus (MLV) recognizes CAT1 as the infection receptor, and enters into host cells by same manner. It is
most likely that the environment around the receptors influences the infection efficiency. In this context, we are studying the effect of receptor glycosylation and lipid factors proximal to the receptor on
the HIV and MLV infection.
On the other hand, there are some evidences
showing that actin-dependent clustering of the receptors is involved in the retrovirus infection. The
receptors, however, do not directly associate with

Visiting Professor

Naoki Yamamoto

Visiting Associate Professor Hironori Sato
Assistant Professor

Laboratory for biochemical research

Yoshinao Kubo

Laboratory for biochemical research
19versity in the characteristics of hosts. We study how

Department of
Eco-epidemiology

microorganism survive, maintain, proliferate, diminish,disappear and emerge through the niches.
The ultimate purpose of the department is toApril 2008, the Research Center for Tropical In-

form a theory for a better understanding of the interre-

fectious Diseases was reorganized and transformed

lationship between hosts and pathogen and its conse-

into four groups i.e. two departments in the Research

quences, diseases.

Field of Environmental Medicine, Tropical Medicine
Museum and the Kenya stationof Overseas Re-

search Stations.
Eco-epidemiology

department is one of the

new two departments in the Research Field of Environmental Medicine.
However, the staffs do not work in the department at present and mainly work for the Kenya Research station of Overseas Research Stations and for
the Tropical Medicine Museum.
Professor Masaaki Shimada (Kenya Station)
Professor Masahiro Horio (Museum)

Prof. Ichinose, collecting stool samples from cholera
patients in an isolation ward.

Professor Satoshi Kaneko (Kenya Station)
Professor Yoshio Ichinose (Kenya Station)
The concept of eco-epidemiology is based on theview of recognizing tropical diseases as a system of
infection. The aim of our research is to understand theprocess of interaction between microorganisms, vectors and human beings in the system.
Human beings and vectors, so-called hosts as aniche of pathogens, exist not statically but dynamically in time and space. In addition, there is an infinite di-Prof. Horio,commentating on tropical diseases at themuseum.

The population pyramid of Suba area.

Staff (Left to right:Shimada, Minakawa, Horio, Kaneko,
and Ichinose)20

Another pillar is a social responsibility. Now thateven profit oriented organizations are required tohave its corporate social responsibility, no need to say
for academia or university. Out of the name of our department, it must be nothing but contribution to international health or people's health in resource limited settings.
Our department raises following three activities
as international contribution; advocacy on international health at national and international level, health promotion activities and empowerment at the community/grassroots' level and emergency relief.
What our department thinks of important in those
activities is to make solidarity in order to improve people's health and contribute to people's sustainable development. It is our department's goal.

Department ofInternational Health
Department of International Health has started its
activities since 2008, following the internal reform ofInstitute of Tropical Medicine. Department of International Health has its basis on Research Center for
Tropical Infectious Diseases (RECTID) of Institute ofTropical Medicine established in 2001, Information
and Reference Center in 1997, and Reference Centerin 1994.
It says that RECTID, a precursor of our department, had following three activities; 1) developing themuseum of tropical medicine, 2) collecting and disseminating information on tropical infectious diseases
and 3) promoting joint research projects and doing epidemiological studies. Out of which, Department of International Health takes over research activities andadds to its mandate an international collaboration as asocial responsibility anew.
Thus, Department of International Health, as a
newly established department, has two pillars, e.g. research and social responsibility.
Research was composed of three units; 1) research on infectious diseases in ecosystem, 2) research on the environment including climate change
and Asian dust related to health, 3) research on biological evolution of microorganisms from the adaptation or fitness view point. The umbrella concept or
key word linking above three research units is to reconstruct infectious diseases temporally and spatially alike. Infection is the biological interaction between hosts and microorganisms. In other words, host
behavior, social structure as well as culture per se affect microorganisms in fitness and adaptation whereas microorganism has impact on its hosts. Based onthat perception, our department aims to get more detailed understanding and insight on infectious diseases.

Professor
Associate Professor
Assistant Professor
Assistant Professor
Visiting Fellow
Visiting Fellow
Research AssistantTechnician
Technician
Assistant Staff
Postgraduate Student
Postgraduate Student
Postgraduate Student
Research Student

21

Taro Yamamoto
Sumihisa Honda
Toshihiko Sunahara
Masahiro Hashizume
Guoxi Cai
Liang Qin
Kyoko Sakitani
Katsuyuki Eguchi
Hidefumi Fujii
Satsuki Shiraishi
Osuke Komazawa
Keiko Akahane
Kounnavong Sengchanh
Tomoko Abetive measures.
７．Reformation and coordination of health manpower traning program / system to meet the need oftropical area in connection with Risk Management.
８．Comparative studies on the control of emerging
infectious diseases in tropical Asia such as West
Nile and SARS or Avian Flu.
９．Study and analysis of the AIDS orphans care system in Thailand.
10．Comparative Studies on the Entamoeba histolytica infections in institutions for mental deficiency between Japan and Mexico.

Department of Global Health
Development Policy Sciences
Specific Features of the Department
This Department covers under the 12th tenure interdisciplinary field of Environmental and Social Medicine related to health services and social welfare problems in developing countries.
Interdisciplinary approach includes studies in Social Sciences and Humanities. Further, methods andactual means of international cooperation toward developing countries has been sought to utilize in orderto promote inter-departmental linkage for information
accumulated with specific analysis and professional
response to the public, particularly in the field of infectious diseases diagnosis and control.
Under this context, basic and applied research
have been carried out in the following prospective
themes from the view point of environmental and social aspects for the purpose of promoting assistanceto minimize health problems in tropical areas:

Specific themes of joint cooperative research designated to the Department under the scheme of Research Institute for Nationally Joint-Use are listed below. The Technical and Management Committee
recommended that interdisciplinary research collaboration should be realized from the viewpoint of middle
and long-term range and managed not only by single
department but also by the whole Institute as one of
the important mandates.
Joint Research projects themes:a) Control and preventive measures for infectious diseases from the view point of the crisis management.
b) Analysis on socio-environmental factors of the control and prevention of infections using the remotesensing and GIS.

Area of Research Activities:
１．Study and analysis on social (incl. life style, political and economical) backgroundwhich regulates frequency / areas / accumulation of diseases of thepresence of epidemics.
２．Study on the effect of individual and social environment toward endemic and epidemics.
３．Standardization of human security measures in
the field of health services from the view points ofnutrition and 3 Es ie.economy, environment and education.
４．Study on control of communicable diseases
among the regional and international health careprograms.
５．Study on quantitative and qualitative values of
medical and health services under the ODA ie. Official Development Assistance programs by Japanese government.
６．Feasibility study on comprehensive information filing and network system for the sake of promoting
health and social welfare services in developing
countries, by epidemics, by regions, by administra-

Noted results of research projects have often
been integrated and fully utilized in the forms of seminar or symposium for covering valuable themes.
We participated in various kinds of national or international meetings regardless of specific field barrier.
Professor
Assistant Professor
Assistant Professor
Research AssistantTechnician
Visiting Researcher
Visiting Researcher
Postgraduate Student

The Dept. often organizes Int'l Symposia.

Tsutomu Mizota
Kensuke Goto
Takeshi Yoda
Rie Ushitani
Emi Nakayama
Chizuko Suzuki
Susumu Tanimura
Kazuo Minematsu

Lecture on Development and Aid in the Master courseof Tropical Medicine.
22

３．Basic studies on newly developed vector control

Department of
Vector Ecology & Environment

measures
Efficacy of newly developed pyrethroid as aspace repellent is evaluated in a laboratory and tropical fields. Improvement of mass rearing and planting

Main interest of the department is analysis of en-techniques of Mesocyclops, which is a hopeful biologi-

vironmental factors that affect the trasmission of in-cal agent against dengue vector mosquito larvae, issect-borne diseases, and pursuing environmental

challenged by laboratory and field trials in Vietnam.

friendly vector control strategy.

Status of insecticide resistance is continuously monitored.

１．Ecology and control strategy of dengue/DHF vec４．Detection of virus in mosquitoes

tors
Ecological mapping of dengue/DHF vectors is

Under collaboration with Department of Virology,

conducted in Vietnam focusing to abandoned tires

ITM and Department of Medical Entomology, NIID de-which are one of main breeding sources of the vec-

tection of virus from a variety of mosquitoes is contin-

tors. An epidemiological study also is conducted atued.

several town blocks in NyaTrang city, southeast Vietnam, to clarify key breeding containers reflecting theProfessor

Masahiro Takagi

life style of local people.

Professor

Noboru Minakawa

Senior Assistant Professor

Hitoshi Kawada

２．Ecological, physiological and genetic studies on ma-

Assistant Professor

Yukiko Higalaria vectors

Assistant Professor

Takashi Tsunoda

Geographical distribution, ecological/physiologi-

Resercher Fellow

Kohei Takano

cal differences, and evolution of malaria vectors com-

Post Doctoral Fellow

Kyoko Futami

posed of the species complex are studied from molec-

Researcher Fellow

Shinya Oda

ular biological and genetic approaches focusing on

Secretary

Toshiko Ueno

Anopheles gambiae group in Africa and An. minimus

Technician

Yuri Sonoda

and An. dirus groups in Asia.

Secretary

Junko Sakemoto

Postgraduate Student

Yoshihide Maekawa

Postgraduate Student

Masaki Sugiura

Postgraduate Student

Ataru Tsuzuki

Stereomicroscopic observation of mosquitoes

Ramp traps for collecting mosquitoes
23Collaborations:
The research here is performed based on thewell arranged collaborative projects with the following
facilities.
１．Malaria: Thammasat University (Thailand), Noguchi Memorial Medical Research Institute (Ghana),
Institute of Medical Research (Malaysia), Karolinska Institute (Sweden), Ehime University (Matsuyama), WHO/TDR (Geneva Switzerland)
２．Schistosmiasis: Jiangxi Provincial Institute of Parasitic Diseases (China), Jiangsu Provincial Instituteof Parasitic Disease(China), Univ. Philippines and
RITM (Manila, Philippines), Tokyo Medical Dental
Univ. (Tokyo)
３．Chagas Disease: Center of Tropical Medicine
and Hospital Japones (Bolivia), IICS University of
Asuncion (Paraguay)

Department of
Immunogenetics
This department is focusing on the pathogenic genetic factors of the host and the parasite in the mostimportant tropical infectious diseases by using immunology and genetics.
Research activities:
To clarify the molecular mechanisms in the protective and/ or pathogenic host response to humanpathogens such as Dengue Virus, TB, Malaria, Trypanosoma cruzi, Schistosoma, and Filaria, the following
research projects are going on in our laboratory.
１．Malaria
１）Genetic susceptibility to severe forms of malaria (cerebral malaria, severe anemia) is analyzed by case-control study in South East Asia,
South Pacific and West Africa.
２）Malaria vaccine development using the immunological characteristics of resistant persons living in the endemic area in Asia and West Africa.

４．Dengu virus
１）Pathogenesis of the DHF (Dengue Hemorragic
Fever)
Host factors will be detected by the Populational
genetic analysis of the patients with DHF andnon DHF.
Staffs２．Schistosomiasis
１）Immunological regulation of the pathogen ic anti egg response in the resistant and susceptible
persons, to post-schistosomal liver fibrosis in China and Philippines.
２）Miniature pig schistosomiasis as a human model.
３）Vaccine development for schitosomiasis japonica and masoria using schistosomula antigens.
４）Production of the new diagnostic Kit for active
infection.
３．Chagas disease１）Genetic susceptibility to different clinical typesof chronia Chagas disease, namely, indeterminate, cardiac, and digestive forms, is analyzed bycase control study in Bolivia where Chagas disease is still highly endemic.
２）Genetic analysis of Trypanosomes in Latia
Americas by using local isolates and molecular biology.

Professor
Kenji Hirayama
Professor (Project)
Michio Yasunami
Associate Professor
Nobu Ohwatari
Senior Assistant Professor (Project)
Mihoko Kikuchi
Assistant Professor
Nguyen Huy Yien
Assistant Professor (Project)
Hiroki Shibata
Industry Academia Goverment Collaboration Researcher Shuaibu Mohammed Nasir〃
Pandy Kishor
Technician
Junko Hayashima
Technician
Hitomi Horie
Assistant Staff
Makiko Okamoto
Ph. D. Student
Akiko Takaki
Ph. D. Student
Ekhlas hamed Abdel Hafeez Abdow
Ph. D. Student
Nguyen Thi Phuong Lan
Ph. D. Student
Akiko Yamazaki
Ph. D. Student
Helegbe Gideon Kofi
Ph. D. Student
Edelwisa Segubre Mendoza
MSc Student
Del Puerto rodas Ramona Florencia
Ph. D. Student
Tran Thi Ngoc Ha

Department of Immunogenetics

Experiment scenery24

３．Study areas for the long-term and extensive research work
The Demographic Surveillance System (DSS)
and Mosquito Surveillance System (MSS) are in operation in the Suba area in Western Kenya. DSS will be
put in the Kwale area on the Coast.

Center for Infectious Disease
Research in Asia and Africa○Kenya Research Station
Outline of the program
The Institute of Tropical Medicine (ITM) has received a government grant for the promotion of research on tropical diseases and emerging and reemerging infectious diseases. With this special, ample
grant of money, ITM established a research station in
Nairobi, Kenya. The unique feature of the Nairobi Station's research program is long-term, extensive, andmultidisciplinary studies based on the Japan-Kenya
collaboration. The program provides training foryoung researchers both Japanese and Kenyan, andin collaboration with JICA, contributes to the disease
control and health promotion in the tropics with thefruits of its research.

４．Studies in infectious tropical diseases
Based on the DSS in Suba, research on malaria
and bacterial diarrhea were launched in 2006 and2007. Study on arbovirus and parasitic diseases started in 2008. In Kwale, research on schistosomiasis
was launched.
５．Training program
Under the patronage of JICA and MEXT, Kenyan researchers and doctors were given apportunities
to visit ITM and were trained in research on tropical
medicine. Professors of ITM served as advisers in the
JICA-sponsored International Parasite Control which
took place in Kenya.

Progress of the program
１．Research station in Kenya
The Research station was set up in the Kenya
Medical Research Institute (KEMRI), Nairobi. KEMRI
is one of the research organizations with which ITM
has long been doing a cooperative research. Basedon the academic agreement between Nagasaki University and KEMRI, the signing ceremony for the newresearch program's Memorandum of Understanding
was held on September 13, 2005. The Research Station is now equipped to facilitate bio-medical and epidemiological studies in tropical diseases. A P3 laboratory and Demographic Surveillance System havebeen prepared.

Program Staff
Program Leader and Professor Masaaki Shimada(Kenya Station)
Professor Yoshio Ichinose (Kenya Station)
Professor Noboru Minakawa (Kenya Station)
Professor Satoshi Kaneko (Kenya Station)
Professor Masahiro Horio (Tropical Medicine Museum)
Administrative Staff Shiho Honda (Kenya Station)
Post-doctorate Fellow Kyoko Futami (Kenya Station)

２．Dispatch of Japanese researchers
Four professors, one is a program leader, andone administrative staff member work in the Kenya
Station. They are to be provided with special logistic
support by one professor of ITM.

Kenya Research Station, Nairobi, Kenya

JSPS Asia-Africa Science Platform Programme Seminar, Nairobi
25１）zoonotic infectious diseases including avian influ-

Center for Infectious Disease
Research in Asia and Africaenza, hanta, nipah virus infection, and rabies;２）vectorborne infectious diseases, including malaria and dengue virus infection;３）fecal-oral infection including rotavirus, norovirus○Vietnam Research Station

infection, and cholera;

Outline of the program４）human to human infection, including acute respi-

In 2005, the Government of Japan (Ministry of Ed-

ratory infections.

ucation, Culture, Sports, Science and Technology)
provided special funds to certain grant-winning Japa-

Update statusnese universities for the purpose of establishing re-

The project document has been approved by thesearch centers for emerging and reemerging infec-

Vietnamese Government, and the Friendship Labora-

tious diseases inorder to make joint studies withtory has been equipped with apparatus for bio-medi-

overseas research institutions. Nagasaki University,

cal and epidemiological studies on infectious diseas-

one of the recipients, set up Research Centers in Na-

es.

gasaki and Hanoi, Viet Nam to study clinical epidemi-

The Center had its opening ceremony on Marchology of emerging and reemerging infectious diseas-

17, 2006 in Hanoi, and started epidemiological study

es, including disease ecology, intervention, andon avian influenza and dengue fever infection while

protection and prevention, thereby contributing to thedeveloping the Demographic Surveillance System forcontrol and/or elimination of infectious diseases,

longbased and extensive infectious diseases studies.

which is today's global concern.
The Research Centers have been managed in collabo-

NIHE-Nagasaki University Friendship Laboratory Staff

ration with four institutions, the Institute of Tropical
Medicine (ITM) of Nagasaki University, the Internation-

Project Leader and Professor

Koichi Morita

al Medical Center of Japan, Tokyo, the National Insti-

Professor

Tetsu Yamashiro

tute of Hygiene and Epidemiology (NIHE), Hanoi, andProfessor

Futoshi Hasebe

Bach Mai Hospital, Hanoi, with ITM and NIHE playing

Professor

Hideki Yanai

a major role in the operation. NIHE has the NIHE-

Assistant Professor

Takashi Tsunoda

Nagasaki University Friendship Laboratory in which

Assistant Professor

Motoi Suzuki

Japanese researchers are now carrying out infectious

Assistant Professor

Gen-ichiro Uechi

diseases research. In Nagasaki, the research proj-

Administrative Staff

Yoshio Furuya

ects focus on basic strategic research and product de-

Research Assistant

Ngo Khanh Phuongvelopment, and also provide guidance for ethical con-

Research Assistant

Quach Thi Thu Huong

sideration and determining of perfect strategies to

Secretary

Bui Thu Tra

counter any potential infectious disease outbreak.
Meanwhile, the research work in Viet Nam willconcentrate on the following areas:

National Institute of Hygiene and Epidemiology (NIHE)

Opening ceremony of the Research Center in NIHE
26

port to the Government and conducting a supplementary immunization activity (SIA) campaign. The Consultant also took part in the creation of an improvement plan for outbreak response. Technology transfer
in this area is consistently provided through country
trainings to improve knowledge and diagnosis of EPI
targeted diseases. In 2007, through a technology
transfer activity, the Department of Virology provided
the Mataika House(Fiji Centre for Communicable Disease Control) skills training on viral diagnostics.
Annual surveys continue to be conducted by JPIPS in the 13 South Pacific island countries, in order
to assess, determine and discuss with counterparts
updates on the occurrence of target communicablediseases and other project issues. Survey results aregathered and published as annual reports. In October
2007, J-PIPS completed the vaccine westage survey
in Fiji in cooperation with divisional EPI coordinators.
This survey is the first of its kind to be conducted in
the 13 Pacific island countries.
J-PIPS maintains close communication and collaboration with its international agency partners suchas WHO, UNICEF, AusAID, NZAID, SPC, as well asother international agencies to ensure a sustained
maximum degree of effectiveness in terms of technical cooperation.
Significantly, the J-PIPS project serves as an avenue for communicable disease control activities, particularly vaccine-preventable diseases, in the Pacific island countries and, thus, is in conformity with the ITM
mission to spearhead research in international healthand make a global contribution through health promotion by applying the results of researchCenter for Infectious Disease
Research in Asia and Africa○Fiji Research Station
The Japanese support to the Pacific Immunization Program Strengthening (J-PIPS) is a 5-year JICA
project in 13 South Pacific island countries. The project aims to strengthen capacity development in the
Pacific in the area of immunization services throughresource development of EPI management staff andto improve the quality of EPI services provided. The Institute of Tropical Medicine (ITM), Nagasaki University(NU), is responsible for the administrative management of J-PIPS. J-PIPS started its operation in February 2005 under the leadership of Dr. Kouichi Morita,
Professor and Head, Department of Virology, ITM,
NU, as its Chief Advisor. In March 2005, four otherprofessionals were assigned to the project office in Suva, Fiji.
The project's two main objectives are: to establish a functioning regional training system for vaccine
logistics, cold chain maintenance, safety injection and
EPI waste disposal management; and to strengthen
the Pacific island countries' EPI program planning andmonitoring system of vaccine-preventable diseases,
such as poliomyelitis, measles, Hepatitis B and influenzae bacillus.
As part of its capacity enhancement program, JPIPS holds regular regional trainings in Suva for
immunization project leaders, as well as supplementary health workers country trainings in each target
country with the active participation and in collaboration with the Fiji Ministry of Health, WHO and UNICEF. The first regional meeting was held from 12 to
16 Dec. 2005,with 43 trainees participating from 13
Pacific island conutries. Cold chain maintenance, vaccine logistics, injection safety, and EPI waste disposal
management were discussed at the training. The second regional training was held the following year, on
20-24 Nov. 2006, with 38 trainees from 14 Pacific island countries participating in two group sessions.
One session dealt with EPI program management,
while the other was on cold chain maintenance. Asidefrom being a technology transfer activity, the regional
trainings are conducted as an evaluation and skills improvement activity for trainers on EPI management,
as well as to enhance their training capacity. The third
regional training was organized along the same concept and was held from 19 to 23 Nov.2007.
When a Measles outbreak occurred in Fiji in
2006, a J-PIPS Epidemiology Consultant actively participated in its containment by providing technical sup-Project Staff
Kouichi Morita, Professor
Yasuhiko Kamiya, Professor
Tatsuhiko Tsukakoshi, Associate Professor
Kenzo Sasagawa, Technician
Hiroshi Osawa, Administrative Staff
Yumiko Nakamura, Administrative Staff

Third PIPS Regional Training (19-23 November, 2007)27

of information on tropical medicine.This has become an essential component of the daily research
activities related to tropical medicine. Due to infrastructure rearrangement in 2007, network tools
were updated with technological innovation andlong lasting safety; thus responding to every needof the users. We also serviced various databases,
using a research evaluation system and a database of the tropical medicine museum. Moreover,within this year we are trying to provide a similar environment to research universities overseas with
VPN by including video conferencing system to promote international conferences and e-learningplans.
The third function is to perform a logistics support role for the Kenya base. The network is also
used for communication with the base, equipment
supply for experiments, and for the database of research results.

Tropical Medicine Museum
Museum of Tropical Medicine was precededby the Tropical Medicine Reference Centre, which
was established in 1974 and was reorganized in
1997 as Tropical Medicine Reference and Information Center. In 2001, it was renamed as ResearchCenter Tropical Infectious Diseases (RECTID) andin 2008 it was established as an auxiliary institution. The institution performs the following 3 functions.
The institute primarily functions as a museum
and resource center for tropical disease.Currently,
on the 1st floor of the Institute of Tropical Medicine
Nagasaki University, there is a general section providing information on tropical diseases, parasites/bacteria/viruses/poisonous insects and specimen of dangerous animals, valuable books, anddisplays images of the data. Moreover, it has an audio-visual room accommodating a few numbers ofpeople. Furthermore, a system is being developedfor using this collection of resources to strengthen
public science and risk communication with thousand points relating to the history and philosophyof tropical medicines and infection symptoms. In
the near future we would like to expand the exhibition room to the museum of tropical medicine andcan be used as an educational resource for society
and educators and provide tropical disease related
research and successful results for the public. In
addition, we plan to display Africa's Nature, Development, and People, in March 2009,as part of
the Ueno Yama Decade of Information series of National Museum of Nature and Science,Tokyo.
It also functions as an information center forthe dispatch, collection, organization, and analysis

28

Professor and head

Kenji Hirayama

Professor

Masahiro Horio

Research AssistantKazuo Araki

Technician

Kiyomi Suda

Technician

Youji Shimizu

Animal Research Center for Tropical Infections

Central Laboratory

The center makes it the principal aim to ensure

There are equipments shared in the institute.

the safety of animal experiments which deal with theThose equipments are maintained and operated bypathogenic microorganisms and to build up the suc-the staffs listed below. There are three major laborato-

cessful generation of experimental animals, microor-ries to be set up, namely electron microscope lab, P3

ganisms and parasites. The building consists of 7

and cell culture lab and molecular biology lab. Elec-

breeding rooms for experimental animals,3 laborato-

tron microscopies (TEM and SEM of jeol), a Ultrami-ries, one breeding room for snails and insects, and acrotome (Reichert), con-focal laser microscope sys-

P3-level biohazard laboratory. The air pressure istem (LEICA DMIREZ), a flow cytometer (Becton),

kept always negative to avoid outflow from inside

Bioimage analizers (Hamamatsu Photonics, Bio radeven at the entrance. Since the building has the mostGS-250 and Pharmacia Image master), DNA sequanc-thorough ventilation through HEPA filters, any mi-ers(Perkin-Elmer), a DNA/RNA extraction system (Qia-crobe cannot leak out to outside of the building. Thegen), two P3 rooms, and 2 dimensional protein purifi-

used water is given chlorination and drained off. The

cation system (Beckman). Following are the major

breeding and experiments are done according to Na-

equipments.

gasaki University Animal Experiment Regulations.
The laboratory animals bred in the center are mice,

Professor

Kouichi Morita

rats, hamsters, gerbils, rabbits, snails and mosqui-

Research Associate

Akitoyo Ichinose

toes.

Technician

Takako Chiba

Director

Osamu Kaneko

Research Associate

Tetsuo Yanagi

Technician

Junko Kawashima

Mongolian gerbil (Meriones unguicalatus)

Lab for Genetic Analysis
29

Clinic at the University Hospital
The Department of Clinical Medicine is the only
one clinical department at the Institute of Tropical
Medicine. It has a clinic and a medical ward with
about 17 beds on the 11th floor of the Nagasaki University Hospital. We specialized in the Infectious Diseases and Chest Medicine; diseases that we handle aresystemic infectious diseases, including tropical diseases and HIV infection, and pneumonia including tuberculosis, and various neoplasmic and inflammatory
respiratory diseases. We actively receive consultations regarding diagnosis and management of infectious diseases from other departments. The outpatient
clinic is open two days a week ,which includes a travel clinic. We are also involved in various clinical trials
such as cancer treatment, antibiotics, GM-CSF therapy for pulmonary alveolar proteinosis. We have also
responsibilities for training medical students (lecturesand bed-side teaching) and for postgraduate training
programs for general internal physicians and infectious disease and chest medicine specialists. Since
April 2006, we have been organizing a clinical caseconference (in English) for tropical diseases as a partof Master of Tropical Medicine course.
Clinic at the University Hospital
Professor
Associate Professor
Lecturer
Assistant Professor
Assistant Professor
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Research Fellow
Resident Physician
Resident Physician
Assistant Professor
Assistant Officer

Koya Ariyoshi
Konosuke Morimoto
Yoshiko Tsuchihashi
Akitsugu Furumoto
Masayuki Ishida
Kazuhiko Koyama
Mayumi Terada
Yoshitaka Harada
Takeshi Tanaka
Kei Matsuki
Mugen Ujiie
Toshiyuki Kusabiraki
Takaharu Shimazaki
Shoko Honda
Kumi Ichise

Clinical conference30Administration
Toshihiro Furukawa, Head Official

Yoko Oya, Staff

Hiroaki Suetsugu, Expert Staff

Junko Suenaga, Assistant Staff
Yumiko Matsumoto, Assistant Staff

General Affairs Unit
Makoto Matsuo, Chief

Asuka Matsuo, Assistant Staff

Risa Yamashita, Sub-Chief

Overseas Research Station Unit

Naomi Ota,Staff

Kenta Sasada, Chief

Miyuki Yamashita, Assistant Staff

Fumiko Hashiguchi, Sub-Chief
Shiho Honda, Staff

Accounting and Facilities Management Unit
Takenobu Hayashida, Chief

Rie Ishikawa, Staff

Tomohiro Ito, Sub-Chief

Idumi Hasegawa, Assistant Staff

Number of Staff(as of August, 2008)

Divisions

Professor

Associate
Professor

Lecturer

Assistant
Professor

Enrollment

10
（7）

4
（2）

3

16
（10）

Assistant Sub total

Others

Total

36
（19）

10
（8）

46
（27）

3

※( ) number of fixed-term staff

Accounting
Revenue (in 2007)

Expedditure (in 2007)

Divisions

Amount（in thousands）

Divisions

Amount（in thousands）

Tuition and Matriculation Fee

2,333

Personnel expenses

497,342

Others156

the cost of equipment

352,737

Total

2,489

Total

850,079

Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (in 2008)
Classification

Scientific Re- Scientific Scientific Scientific Scientific Scientific Exploratory Y o u n g
search on Research Research Research Research Research
Scientists
Research
Priority Areas （A）
（A）
（B）
（B）
（C）
（B）

Total

Number of Grants

1

2

1

6

1

3

1

3

18

Amount(in thousands)

7,900

22,62016,51027,040

7,930

6,370

600

6,500

95,47031

Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare
Classification

International Emerging andResearch Fund Project on
MedicalReemerging AIDS Control Health Sciences focusing
Cooperation Infectious Diseases
on Drug Innnovation(in 2008）

Clinical Cancer

Total

Number of Grants

2

3

2

1

1

8

Amount（in thousands）

16,461

6,800

6,800

2,000

500

32,561

Grant-in-Aid for Forming Research Locations etc (Global COE)
Fiscal Year

2008

Amount（in thousands）

342,940

External Funding(in 2008)

Divisions

Cooperative ResearchCommissioned

Endowments

Number of Sources

1

8

22

Amount（in thousands）

2,000

15,715

15,101

Agreement of Educational, Scientific and Scholaly Exchange
Name of organization of partner countries

Concluded date

Chiang Mai University (Thailand)

February，1988

Mahidol University (Thailand)

November，1999

Philippines University Diliman (Philippines)

April, 2001

Institute of Hygiene and Epidemiology (Vietnam)

June, 2001

Airlangga University (Indonesia)

January, 2004

St. Luke's Medical Center (Philippines)

February, 2004

SAH LAZARO HOSPITAL MEDICAL CEHTER (Philippines)

August, 2004

KENYA MEDICAL RESEARCH INSTITUTE (KENYA)

November, 2004

THAMMASAT University (Thailand)

March, 200632

Location map of the Institute ofTropical Medicine on SakamotoCampus of Nagasaki University

PlaygroundGymnasium

Laboratory Animal Center
for Biomedical Research

Parking
Medical Materials
Center for Atomic
Bomb Casuality

Radioisotope
Center
Sub-Gate

Parking

Tropical Medicine Musium(In part of the 1st Floor)
Research in Asia and Africa(In part of the 2st Floor)

Main Building of
the Institute ofTropical Medicine(7,835㎡）

School of Medicine
AtomicDiseaseInstitute

Animal Research Center for
Tropical Infections(490㎡)

Main Gate
Pompe
Hall

MedicalBranchLibrary
Commemoration
Hall

Back Gate

Alumni HallN

for University Hospital
RyoJunHall

33

Telephone Number
Institute of Tropical Medicine, Nagasaki University

０９５
（８１９）
７８００
Extensions

Dean ……………………………………………………………… ７８０１
Head of Administrative Office ………………………………… ７８０２
Expert Staff ……………………………………………………… ７８１３
Chief of General Affairs Unit …………………………………… ４７０２
General Affairs Unit ……………………………………………… ７８０３
Chief of Accounting and Facilities Management Unit ……………… ４７０６
Accounting and Facilities Management Unit ………………… ７８０７
Accounting and Facilities Management Unit ………………… ７８１６
Chief of Overseas Research Station Unit …………………… ４７０９
Overseas Research Station Unit ……………………………… ７８０６
Facsimile ………………………………………………………… ７８０５
Meeting Room …………………………………………………… ４７１１
Department of Virology
Professor …………………………………………… ７８２７Associate Professor ……………………………… ７８２８
Information ………………………………………… ７８２９
Facsimile …………………………………………… ７８３０
Department of Bacteriology
Professor …………………………………………… ７８３１
Lab.2 ………………………………………………… ７８３２
Lab.1,Lab.3 ………………………………………… ７８３３
Department of Protozoology
Professor …………………………………………… ７８３５
Lab.2 ………………………………………………… ７８３６
Lab.1 ………………………………………………… ７８３７
Information ………………………………………… ７８３８Department of Parasitology
Professor …………………………………………… ７８２２
Staff rooom ………………………………………… ７８２３
Facsimile …………………………………………… ７８２４
Information ………………………………………… ７８２５
Department of Molecular Epidemiology
Professor …………………………………………… ７８６０
Department of Clinical Medicine
Professor …………………………………………… ７８４０
Associate Professor ……………………………… ７８７３
Information ………………………………………… ７８４１
Information ………………………………………… ７８４２
Facsimile …………………………………………… ７８４３
Department of Host-Defense Biochemistry
Professor …………………………………………… ７８４８
Lab.1 ………………………………………………… ７８４９
Culture room ……………………………………… ７８５０
Information ………………………………………… ７８５１

34

８１９−７８０１
８１９−７８０２
８１９−７８０３
８１９−７８０７

８１９−７８０６
８１９−７８０５

８１９−７８２７
８１９−７８２８
８１９−７８２９
８１９−７８３０
８１９−７８３１
８１９−７８３２
８１９−７８３３
８１９−７８３５
８１９−７８３６
８１９−７８３７
８１９−７８３８
８１９−７８２２
８１９−７８２３
８１９−７８２４
８１９−７８２５
８１９−７８６０
８１９−７８４０
８１９−７８７３
８１９−７８４１
８１９−７８４２
８１９−７８４３
８１９−７８４８
８１９−７８４９
８１９−７８５０
８１９−７８５１

Department of Pathology
Professor …………………………………………… ７８１３
Assistant Professor ……………………………… ７８１４
Staff room ………………………………………… ７８１５
Staff room ………………………………………… ７８１６Intormation ………………………………………… ７８７０
Department of Preventive Medicine and AIDS ResearchLaboratory ………………………………………… ７８４４
Information1 ……………………………………… ７８４５
Information2 ……………………………………… ７８４６
Department of Eco-epidemiology
Professor …………………………………………… ７８５４
Information ………………………………………… ７８６８
Department of International HealthProfessor …………………………………………… ７８６９
Associate Professor ……………………………… ７８５３
Lab.1 ………………………………………………… ７８５３
Information ………………………………………… ７８６８
Department of Global Health Development Policy Sciences
Professor …………………………………………… ７８６４
Staff room ………………………………………… ７８６５
Information ………………………………………… ７８６６
Facsimile …………………………………………… ７８６７
Department of Vector Ecology and Environment
Professor …………………………………………… ７８１０
Staff room ………………………………………… ７８１１
Information ………………………………………… ７８０９
Facsimile …………………………………………… ７８１２
Department of Immunogenetics
Professor …………………………………………… ７８１８Assistant Professor ……………………………… ７８１９
Information ………………………………………… ７８２０
Facsimile …………………………………………… ７８２１
Animal Resach Center for Tropical Infections
Information ………………………………………… ７８５６
Tropical Medicine Museum
Professor …………………………………………… ７８１７
Information ………………………………………… ７８６８
Central Laboratory
Electron Microscope Room ……………………… ７８５９35

８１９−７８１３
８１９−７８１４
８１９−７８１５
８１９−７８１６
８１９−７８７０
８１９−７８４４
８１９−７８４５
８１９−７８４６
８１９−７８５４
８１９−７８６８
８１９−７８６９
８１９−７８５３
８１９−７８５３
８１９−７８６８
８１９−７８６４
８１９−７８６５
８１９−７８６６
８１９−７８６７
８１９−７８１０
８１９−７８１１
８１９−７８０９
８１９−７８１２
８１９−７８１８
８１９−７８１９
８１９−７８２０
８１９−７８２１
８１９−７８５６
８１９−７８１７
８１９−７８６８
８１９−７８５９

Location map of the Institute of Tropical Medicine,
Nagasaki University in Nagasaki City

Mt.InasaN

Ropeway

Nagasaki Bay

Urakami

fo

rK

og

ak

ur

Hamaguchi-machi
Urakamieki-maeaNagasakiMatsuyama-machi

Ohashifor Akasako

Igakubu-mae
School of
Dentistry
Nagasakieki-mae

Ohato

University
Hospital

School ofMedicine

Urakamitenshudo-mae

Isibashi
Tsukimachi

Prefectural Office
県庁

Institute of Tropical
Medicine

City Hall

Chuobashi

Kokaido-mae
Suwajinja-mae

JR Kyushu
Streetcar

Shokakuji-shita

Main bus routfor Mogi

for Hotarujaya

How to get the Institute
1. From Nagasaki Station (JR Kyushu)①Get on a bus (Nagasaki Bus, Line 8) at Nagasakieki-mae and get off at Igakubu-mae.
Five minutes walk from the bus stop.
②Get on a streetcar at Nagasakieki-mae (for Akasako, Line 1 or 3), and get off at
Hamaguchi-machi. Ten minutes walk from the streetcar stop.
③Ten minutes by taxi from the station.
2. From Urakami Station (JR Kyushu）①Twenty minutes walk. ②Get on a bus (Genkikun) at Urakamieki-mae and get off at
Daigakubyoin-mae. Five minutes walk from the bus stop. ③Five minutes taxi.
3. From Nagasaki Airport①Get on limousine at the airport (for Nagasaki), and get off at Nagasaki-ekimae, andthen continue to 1．
②Get on limousine at the airport (for Nagasaki), and get off at Matsuyama-machi, andthen fifteen minutes walk from the bus stop or 5 minutes by taxi.
③About one hour by taxi from the airport.
Location
1-12-4 Sakamoto Nagasaki 852-8523
URL http://www.tm.nagasaki-u.ac.jp

Published on August,31 2008
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Heiwado Printing Co., 5-11 dejima chou, Nagasaki 850-0862, Japan