ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧔ሶߤ߽ኅᐸ✚ว⎇ⓥ੐ᬺ㧕ಽᜂ⎇ⓥႎ๔ᦠಽᜂ⺖㗴㧦᛫࡝ࡦ⢽⾰᛫૕ߦࠃࠆਇ⢒∝⊒∝ࡔࠞ࠾࠭ࡓߦ㑐ߔࠆ⎇ⓥ
⎇ⓥಽᜂ⠪ ⮮੗ ⍮ⴕ ᧲੩ᄢቇ↥⑼ᇚੱ⑼ቇಎᢎ᝼
⎇ⓥⷐᣦ
⠌ᘠᵹ↥ߩ࡝ࠬࠢࡈࠔࠢ࠲࡯ߢ޽ࠆ᛫࡝ࡦ⢽⾰᛫૕(aPL)ߩਛߢ‫ߦ․ޔ‬E2GPIଐሽᕈaPLߩ‫ⴊޔ‬ᶧಝ࿕⇣Ᏹએᄖߩᵹ↥⊒∝ࡔࠞ࠾࠭ࡓߦߟ޿ߡ‫ޔ‬CD1d᛫ේߦᵈ⋡ߒߡ⎇ⓥ
ߒߡ޿ࠆ‫ޕ‬CD1d᛫ේߪࡅ࠻⊕ⴊ⃿᛫ේ(HLA)㘃ૃߩ⤑Ⱞ⊕⾰ߢ޽ࠅ‫⥄ޔ‬Ꮖߩ࡝ࡦ⢽⾰ࠍ฽߻࡝ࡦ⢽⾰ࠍឭ␜ߒ‫ޔ‬ೋᦼߩ⢝⋚extravillous trophoblast⴫㕙ߦ⊒⃻ߒߡ޿ࠆ‫ޕ‬ᤓᐕᐲߩ⎇ⓥߦ߅޿ߡ‫ޔ‬ᚒ‫ޔߪޘ‬᛫E 2GPI᛫૕߇‫ޔ‬PS-E 2GPIⶄว૕ߣ⚿วߒߚtrophoblast⴫㕙ߩCD1dߣ㑆ធ⊛ߦ⚿วߒ‫⋧ߩߘޔ‬੕૞↪ߦࠃߞߡCD1dߩ᨞ᯅ෻ᔕ߇⿠ߎࠅ‫ޔ‬CD1dࠍ⊒⃻ߔࠆtrophoblast߆ࠄߩIL-12 ⺃ዉ߇⿠ߎࠆߎߣࠍ᣿ࠄ߆ߦߒߚ‫ޕ‬ᅧᆼೋᦼߦ‫ޔ‬extravillous trophoblast਄ߩCD1dߣᲣ૕᛫E 2GPIଐሽᕈaPL߇෻ᔕߔࠆߎߣߦࠃ
ࠅㆊ೾ߥἻ∝ᕈ෻ᔕ߇⿠ߎߞߡ‫ޔ‬ᵹ↥߇⊒∝ߒ߁ࠆߣ⠨߃ࠄࠇߚ‫ᧄޕ‬ᐕᐲߪ‫ߎޔߕ߹ޔ‬ߩ⃻⽎߇‫ޔ‬ᖚ⠪ⴊᷡߢ߽⺃ዉߐࠇࠆ߆ᬌ⸛ߒߚ‫⚿ߩߘޕ‬ᨐ‫ޔ‬ਇ⢒∝ᖚ⠪ⴊᷡਛE 2GPIଐሽᕈ᛫cardiolipin᛫૕ߦࠃߞߡ߽CD1dߩ᨞ᯅ෻ᔕ߇⿠ߎߞߡIL-12 ߇⺃ዉߐࠇࠆߎߣ߇ࠊ߆ࠅ‫ޔ‬CD1d߇aPLߦࠃࠆᵹ↥⊒∝ࡔࠞ࠾࠭ࡓߦታ㓙ߦ߆߆ࠊߞߡ޿ࠆน⢻ᕈ߇␜ߐࠇߚ‫ᧄޕ‬ᐕᐲߪ߹ߚ‫ޔ‬᛫E 2GPI᛫૕ߦࠃࠆ਄⸥෻ᔕߦ‫ޔ‬CD1dࠍ⹺⼂ߒߡ෻ᔕߔࠆ
⣕⪭⤑natural killer T (NKT)⚦⢩߇ߎߩ෻ᔕߦᓇ㗀ߒߡ޿ࠆน⢻ᕈࠍ⠨߃‫ޔ‬⣕⪭⤑NKT⚦⢩ߣtrophoblastߣߩ⋧੕૞↪ࠍ᣿ࠄ߆ߦߔࠆߎߣߦߒߚ‫࠻ࡅޕ‬⣕⪭⤑࡝ࡦࡄ⃿
߆ࠄNKT⚦⢩ࠍ⺃ዉߒ‫ޔ‬CD1dࠍᒝ೙⊒⃻ߐߖߚ⛐Ძ≸⚦⢩ᩣߣ౒ၭ㙃ߒߚ‫⚿ߩߘޕ‬ᨐ‫ޔ‬ࡅ࠻⣕⪭⤑NKT⚦⢩߇‫ޔ‬CD1dࠍ੺ߒߡ⛐Ძ⚦⢩߆ࠄߩἻ∝ᕈࠨࠗ࠻ࠞࠗࡦIL12 ߩ↥↢ࠍ⺃ዉߔࠆߎߣ߇ࠊ߆ߞߚ‫ޔߒ߆ߒޕ‬CD1dࠍ⹺⼂ߒߚNKT⚦⢩߆ࠄߩ․⇣⊛ࠨࠗ࠻ࠞࠗࡦಽᴲᄌൻߪ⏕⹺ߢ߈ߥ߆ߞߚ‫ޕ‬ᰴᐕᐲߪ‫ޔ‬᛫E 2GPI᛫૕ࠍᷝടߒߡcross-linkingࠍ⺃ዉߒߚJeg3/CD1d⚦⢩ߩၭ㙃਄ᷡࠍNKT⚦⢩ߦᷝടߒ‫ޔ‬IFN-J߇⺃ዉߐࠇࠆ߆ᬌ⸛ߔࠆ੍ቯߢ޽ࠆ‫ޕ‬㧭㧚⎇ⓥ⋡⊛
᛫࡝ࡦ⢽⾰᛫૕(aPL)ߪਇ⢒∝ߩ࡝ࠬࠢࡈࠔࠢ࠲࡯ߢ޽ࠆ‫ޕ‬aPL߇㑐ਈߔࠆᵹ↥ߢߪⴊᶧಝ࿕⇣ᵹ↥ࠍ⊒∝ߐߖࠆߣߐࠇߡ޿ࠆ߇‫ᦨޔ‬ㄭ‫ޔ‬
trophoblast߳ߩ⋥ធ⊛ߥ⚦⢩்ኂ૞↪ߦࠃࠆೋᦼ⠌ᘠᵹ↥⊒∝ᯏォ߽ႎ๔ߐࠇߚ‫ޕ‬Ᏹࠍ੺ߔࠆࡔࠞ࠾࠭ࡓ߇ឭ໒ߐࠇߡ߅ࠅ‫ޔ‬⢝⋚ⴊCD1d ᛫ේߪ‫ޔ‬HLA ㄭற㗔ၞߢࠦ࡯࠼ߐࠇࠆ▤ౝߩⴊᩖᒻᚑߦࠃࠅ⢝⋚ᯏ⢻߇㓚ኂߐࠇߡ‫ޔ‬ᵹ

HLA 㘃ૃ᛫ේߢ޽ࠅ‫ޔ‬trophoblast ߦ⊒⃻ߐࠇߡᱫ↥߇⿠ߎࠆߣߐࠇߡ޿ࠆ‫ޔߒ߆ߒޕ‬aPLߪ⢝⋚޿ࠆ‫ߩߎޕ‬᛫ේߪ HLA class I ᛫ේߣ߶߷ห᭽ߩⴊ▤ᧂᒻᚑߩᅧᆼೋᦼᵹ↥ࠍ෻ᓳߔࠆ⠌ᘠᵹ↥᭴ ㅧ ࠍ ᜬ ߜ ‫ ޔ‬invariant natural killer T cellߦ߽㑐ㅪᕈ߇ႎ๔ߐࠇߡ߅ࠅ‫ߩߘޔ‬ᵹ↥⊒∝ࡔࠞ(iNKT)ߦ⹺⼂ߐࠇ‫ࠅࠃߦࠇߘޔ‬෺ᣇߩ⚦⢩߆ࠄಽ࠾࠭ࡓߪᔅߕߒ߽᣿ࠄ߆ߦߥߞߡ޿ߥ޿‫ޕ‬aPLߩ

ᴲߐࠇࠆ T helper 1 (Th1)ࠨࠗ࠻ࠞࠗࡦࠍ੺ߒߚ

ਛߢ߽‫ޔ‬ਇ⢒∝ࠍᒁ߈⿠ߎߔജ߇․ߦᒝ޿ߣ⠨߃ዪᚲἻ∝෻ᔕࠍ⺃ዉߔࠆ௛߈ࠍ᦭ߒߡ޿ࠆ‫ޕ‬ታࠄࠇߡ޿ࠆE2glycoproteinΣ㧔E2GPI㧕ଐሽᕈaPL㓙‫↥ޔ‬ᇚੱ⑼㗔ၞߦ߅޿ߡ߽‫ޔ‬ሶች㗪▤਄⊹⚦⢩ߪ‫ޔ‬㒶ᕈ⩄㔚ࠍᜬߟ࡝ࡦ⢽⾰ߣ⚿วߒߚ E2GPI߇ CD1d ᛫ේࠍ⊒⃻ߒ‫ޔ‬ዪᚲߩ iNKT ߥߤߩ఺∉ߣ෻ᔕߒ‫ⴊޔ‬ᩖᒻᚑࠍ⺃ዉߔࠆߎߣߦࠃࠅ‫ޔ‬ਛᦼ⚦⢩ߣߩ⋧੕૞↪ߦࠃࠅ‫ߩ⤑☼ޔ‬ᗵᨴ㒐ᓮ෻ᔕߦ

143㊀ⷐߥ㑐ਈࠍߒߡ޿ࠆߎߣ߇ࠊ߆ߞߡ޿ࠆ‫৻ޕ‬ዪᚲߢ޽ࠆሶችߦ߅޿ߡߪ‫ޔ‬⣕⪭⤑ౝߦCD1dࠍᣇ‫ޔ‬iNKT ⚦⢩ߪሶች⣕⪭⤑ߦ߽ሽ࿷ߔࠆߎߣ߇

⹺⼂ߒߡ෻ᔕߔࠆnatural killer T (NKT)⚦⢩߇ࠊ߆ߞߡ߅ࠅ‫ޔ‬trophoblast ߇ CD1d ᛫ේࠍ⊒⃻ሽ࿷ߒߡ߅ࠅ‫ޔ‬᛫E 2GPI᛫૕ߦࠃࠆ਄⸥෻ᔕߦᓇߒߡ޿ࠆߎߣߣวࠊߖߡ‫ޔ‬ᅧᆼ఺∉ߦ CD1d ᛫ේ㗀ߒߡ޿ࠆน⢻ᕈ߇޽ࠆ‫ᧄߢߎߘޕ‬ᐕᐲߩ⎇ⓥߦ

߇㊀ⷐߥ௛߈ࠍߒߡ޿ࠆߎߣ߇⠨߃ࠄࠇࠆ‫߹ޕ‬߅޿ߡ‫ޔ‬⣕⪭⤑iNKT⚦⢩ߣtrophoblastߣߩ⋧੕ߚ‫ޔ‬CD1d ಽሶߪ‫ޔ‬᛫ CD1d ᛫૕ߦࠃࠅಽሶ᨞ᯅ૞↪ࠍ᣿ࠄ߆ߦߔࠆߎߣߦߒߚ‫ޕ‬෻ᔕࠍ߅ߎߒ‫⚦ޔ‬⢩ౝߩ࡝ࡦ㉄ൻࠞࠬࠤ࡯࠼ߦࠃࠅ‫ޔ‬interleukin (IL)-12 ߥߤߩࠨࠗ࠻ࠞࠗࡦಽᴲ

㧮㧚⎇ⓥᣇᴺࠍ⺃ዉߒ‫ޔ‬Th1 ෻ᔕࠍዉߊߎߣ߽⍮ࠄࠇߡ޿ࠆ‫ޕ‬1.

E 2GPIଐሽᕈ᛫cardiolipin᛫૕㓁ᕈਇ⢒∝ߐࠄߦ‫ޔ‬human leukocyte antigen (HLA)߇ࡍࡊ

ߩᖚ⠪ⴊᷡࠍJeg3/CD1dၭ㙃♽ߦᷝടߒ‫ޔ‬ၭ࠴࠼ࠍ⚦⢩⴫㕙ߦឭ␜ߔࠆߩߣ⇣ߥࠅ‫ޔ‬CD1d ᛫㙃਄ᷡਛ߳ߩIL-12 ߩಽᴲࠍ‫ޔ‬ELISAߢᬌ⸛ේߪ࡝ࡦ⢽⾰ࠍឭ␜ߔࠆ૞↪ࠍ᦭ߒߡ޿ࠆߎߣߒߚ‫ޕ‬߆ࠄ‫ޔ‬ਇ⢒∝ߩේ࿃ߢ޽ࠆ᛫࡝ࡦ⢽⾰᛫૕∝୥⟲2.

ߩ∛ᘒߦ㊀ⷐߥ㑐ਈࠍߒߡ޿ࠆน⢻ᕈ߇޽ࠆ‫ޕ‬޿ߡ⣕⪭⤑࡝ࡦࡄ⃿ࠍಽ㔌ߒ‫ޔ‬iNKT ⚦⢩ߩჇᱺ⺃ዉ೷DGalCer ࠍᷝടߒߡ 7 ᣣ㑆ၭ㙃ߘߎߢᤓᐕᐲߩ⎇ⓥߦ߅޿ߡ‫ޔ‬trophoblast਄ߒߚ‫ޕ‬

ߩCD1dࠍ੺ߒߚE2GPIଐሽᕈaPLߦࠃࠆᵹ↥ࡔࠞ࠾࠭ࡓࠍ⸃᣿ߔࠆߎߣࠍ⋡⊛ߣߒ‫ޔߦ․ޔ‬㧝㧚3.

ߎߩ⣕⪭⤑࡝ࡦࡄ⃿ࠍ Jeg3/CD1d ߽ߒߊߪJeg3 ߣ౒ၭ㙃ߒߚ‫ޕ‬trophoblast਄ߩCD1d߇࡝ࡦ⢽⾰ࠍ᛫ේឭ␜ߒ‫ޔ‬ߎߩ࡝ࡦ⢽⾰ߦE2GPI߇⚿วߒߡ޿ࠆߎߣ‫ޔ‬㧞㧚ੱᎿਛ⛘∝଀߆ࠄណขߒߚࡅ࠻⣕⪭⤑ࠍ↪

4.

Interferon (IFN)-J ‫ ޔ‬IL-4 ‫ ޔ‬IL-12 ⺃ ዉ ࠍ

᛫E2GPI᛫૕ߦࠃࠅ‫ޔ‬CD1dߩಽሶ᨞ᯅ෻ᔕ߇⺃

ELISA ᴺ߅ࠃ߮ቯ㊂⊛ RT-PCR ᴺߢⷰኤߒዉߐࠇߡ‫ޔ‬trophoblast߆ࠄIL12 ߥߤߩࠨࠗ࠻ࠞߚ‫ޕ‬ࠗࡦಽᴲ߇⿠ߎࠆߎߣ‫ ߩޔ‬2 ὐߦߟ޿ߡᬌ⸛ߒ

5.

IFN-J↥↢⚦⢩ߩሽ࿷ࠍ ELISPOT ᴺߢⷰኤߚ ‫ ⚿ ߩ ߘ ޕ‬ᨐ ‫ ޔ‬CD1d ࠍ ᕡ Ᏹ ⊛ ߦ ⊒ ⃻ ߔ ࠆߒߚ‫ޕ‬

trophoblastᩣJeg3/CD1dߩ⴫㕙ߦ߅޿ߡ‫ޔ‬CD1d(୶ℂ㕙߳ߩ㈩ᘦ)⊒⃻ߦ৻⥌ߒߡPS‫ޔ‬E 2GPI߇ሽ࿷ߒߡ޿ࠆߎߣࠍ⥃ᐥᬌ૕ߩណข‫ޔߪ↪૶ޔ‬ᣉ⸳୶ℂᆔຬળߩ⏕⹺ߒ‫ޔߚ߹ޔ‬᛫CD1d᛫૕ߦട߃‫ޔ‬᛫E 2GPI᛫ᛚ⹺ߩ߽ߣ‫ࠍ࠻ࡦ࠮ࡦࠦ࡮࠼ࡓ࡯ࠜࡈࡦࠗޔ‬ข૕ߢ߽᨞ᯅ෻ᔕߦࠃࠆIL-12 ߩ⊒⃻߇⹺߼ࠄࠇ‫ޔ‬ᓧߒߡ‫ޔ‬ታᣉߒߚ‫ޕ‬

᛫E 2GPI᛫૕߇‫ޔ‬PS-E 2GPIⶄว૕ߣ⚿วߒߚ

144

trophoblast ⴫㕙ߩCD1dߣ㑆ធ⊛ߦ⚿วߒ‫ߘޔ‬㧯㧚⎇ⓥ⚿ᨐ

ߩ⋧੕૞↪ߦࠃߞߡCD1dߩ᨞ᯅ෻ᔕ߇⿠ߎࠅ‫ޔ‬䋱䋮E 2GPIଐሽᕈ᛫cardiolipin᛫૕㓁ᕈਇ⢒∝ߩCD1dࠍ⊒⃻ߔࠆtrophoblast߆ࠄߩIL-12 ⺃ዉ߇ᖚ⠪ⴊᷡࠍJeg3/CD1dၭ㙃♽ߦᷝടߔࠆߣ‫ޔ‬⿠ߎࠆߎߣࠍ᣿ࠄ߆ߦߒߚ‫ޕ‬ᅧᆼೋᦼߦ‫ޔ‬਄ᷡਛ߳ߩIL-12 ߩಽᴲ߇⏕⹺ߐࠇߚ‫ޕ‬extravillous trophoblast ਄ ߩ CD1d ߣ Უ ૕ ᛫ E䋲䋮ࡈࡠ࡯ࠨࠗ࠻ࡔ࠻࡝࡯ᴺߦࠃࠆ⸃ᨆߢ‫࠻ࡅޔ‬

2GPIଐሽᕈaPL߇෻ᔕߔࠆߎߣߦࠃࠅㆊ೾ߥἻ⣕⪭⤑࡝ࡦࡄ⃿ߦኻߔࠆDGalCer ೝỗߦࠃ∝ᕈ෻ᔕ߇⿠ߎߞߡ‫ޔ‬ᵹ↥߇⊒∝ߒ߁ࠆߣ⠨߃ࠄࠅ VD24VE11 㓁ᕈߩ⣕⪭⤑ iNKT ⚦⢩ᢙ߇Ⴧࠇߚ‫ޕ‬ടߔࠆߎߣ߇⏕⹺ߐࠇߚ‫ޕ‬ᧄᐕᐲߩ⎇ⓥߦ߅޿ߡߪ‫ޔ߇⽎⃻ߩߎޔߕ߹ޔ‬䋳䋮ELISA ᴺߢߪ‫ޔ‬Jeg3/CD1d ߣߩ౒ၭ㙃ߢᖚ⠪ⴊᷡߢ߽⺃ዉߐࠇࠆ߆ᬌ⸛ߒߚ‫ޔߚ߹ޕ‬ᅧᆼIL12 ⺃ዉ߇⏕⹺ߐࠇߚ߇‫ޔ‬Jeg3 ߣߩ౒ၭ㙃ߢߪ⏕⹺ߢ߈ߥ߆ߞߚ‫ޕ‬ ⺰ᢥ⊒⴫ߥߒ

䋴䋮RT-PCR ᴺߢ Jeg3/CD1d ⚦⢩ߢ IL12 ⺃ዉ߇⏕⹺ߐࠇ‫ޔ‬IL12 ߪ Jeg3/CD1d ↱᧪ߢ޽ࠆߎ ቇળ⊒⴫ߣ߇ಽ߆ߞߚ‫ޕ‬1)ጤỈ᦭Ꮧ, Ꮉฬᢘ, ⮮੗⍮ⴕ, ᳗᧻ஜ, ᧻ᧄ㗅ሶ, ਃᶆ⚡଻, ศ↰ᔒᦶ, ౓⮮ඳା,

䋵䋮ELISA ᴺߢߪ⣕⪭⤑ iNKT ⚦⢩߆ࠄߩ IL4‫ޔ‬ጊਅ㓉ඳ, ਄ᆄᔒ㇢, ᱞ⼱㓶ੑ: ⛐Ძ⚦

IFN-J⺃ዉߪ⏕⹺ߢ߈ߥ߆ߞߚ‫ޕ‬⢩਄ߦሽ࿷ߔࠆ࡝ࡦ⢽⾰᛫ේឭ␜ಽሶ

䋶䋮ELISPOT ᴺߢ IFN-J↥↢⚦⢩ࠍ⹺߼ߚ߇‫ޔ‬IFN-J↥↢⚦⢩ᢙߪ Jeg3/CD1d ߣߩ౒ၭ㙃‫ޔ‬‫ޟ‬CD1d‫ޔߚߒ੺ࠍޠ‬E2glycoproteinIଐ

Jeg3 ߣߩ౒ၭ㙃ߢᏅ߇ߥ߆ߞߚ‫ޕ‬ሽᕈ᛫࡝ࡦ⢽⾰᛫૕ߦࠃࠆᣂⷙᵹ↥ࡔࠞ࠾࠭ࡓߦ㑐ߔࠆᬌ⸛. ╙ 61 ࿁ᣣᧄ↥⑼ᇚੱ⑼ቇળ✚ળ࡮ቇⴚ⻠Ṷળ, ੩ㇺ,㧰㧚⠨ኤ੹ ࿁ ߩ ⎇ ⓥ ߦ ࠃ ࠅ ‫ ޔ‬E 2GPI ଐ ሽ ᕈ ᛫cardiolipin᛫૕㓁ᕈਇ⢒∝ߩᖚ⠪ⴊᷡਛ᛫૕2009.4.
2)

Iwasawa Y, Kawana K, Fujii T,ߦࠃߞߡ߽CD1dߩ᨞ᯅ෻ᔕ߇⿠ߎࠆߎߣ߇ࠊ

Nagamatsu T, Matsumoto J, Miura S,߆ࠅ‫ޔ‬CD1d߇aPLߦࠃࠆᵹ↥⊒∝ࡔࠞ࠾࠭ࡓYamashita T, Hyodo H, Kozuma S,ߦታ㓙ߦ߆߆ࠊߞߡ޿ࠆน⢻ᕈ߇␜ߐࠇߚ‫ޕ‬⣕

Taketani Y: A possible pathogenic⪭⤑iNKTߣCD1dߣߩ⋧੕૞↪ߦ㑐ߔࠆ⎇ⓥmechanism of recurrent miscarriageߢߪ‫ޔ‬⣕⪭⤑iNKT⚦⢩ߪ‫ޔ‬CD1dࠍ੺ߒߡ⛐associated with E2 glycoproteinᲫ⚦⢩߆ࠄߩἻ∝ᕈࠨࠗ࠻ࠞࠗࡦIL12 ߩ↥↢

I-dependent antiphospholipid antibodyࠍ⺃ዉߔࠆߎߣ߇ࠊ߆ߞߚ‫ޔߒ߆ߒޕ‬CD1d߇

through the function of CD1d.

iNKT߆ࠄߩIFNJߩಽᴲࠍ․⇣⊛ߦჇ߿ߒߡ

Annual Meeting of The American޿ࠆߣ޿߁⸽᜚ߪᓧࠄࠇߥ߆ߞߚ‫ޕ‬ᰴᐕᐲߪ‫ޔ‬Society for Reproductive Immunology,

᛫E 2GPI᛫૕ࠍᷝടߒߡcross-linkingࠍ⺃ዉOrlando, FL, USA, 2009.6.

ߒߚJeg3/CD1d⚦⢩ߩၭ㙃਄ᷡࠍiNKTߦᷝടߒ‫ޔ‬IFN-J߇⺃ዉߐࠇࠆ߆ᬌ⸛ߔࠆ੍ቯߢ޽ࠆ‫ޕ‬㧱㧚⚿⺰3)

29thIwasawa Y, Kawana K, Miura S, Fujii T:
A novel pathogenic mechanism ofrecurrent miscarriage associated withE2glycoprotein I-dependent

CD1d ߇ aPL ߦࠃࠆᵹ↥⊒∝ࡔࠞ࠾࠭ࡓߦታ

antiphospholipid antibody through CD1d㓙ߦ߆߆ࠊߞߡ޿ࠆน⢻ᕈ߇␜ߐࠇߚ‫ޔߚ߹ޕ‬⣕on the trophoblast. 14th International⪭⤑ iNKT ⚦⢩ߪ‫ޔ‬CD1d ࠍ੺ߒߡ⛐Ძ⚦⢩߆ࠄCongress of Mucosal Immunology.

ߩἻ∝ᕈࠨࠗ࠻ࠞࠗࡦߩ↥↢ࠍ⺞▵ߒ‫ޔ‬਄⸥ᵹ↥

Boston, MA, USA, 2009.7.

⊒∝ߦ㑐ࠊߞߡ޿ࠆน⢻ᕈ߇␜ໂߐࠇߚ‫ޕ‬㧴㧚⍮⊛⽷↥ᮭߩ಴㗿࡮⊓㍳⁁ᴫ㧔੍ቯࠍ฽߻‫ޕ‬㧕㧲㧚ஜᐽෂ㒾ᖱႎ

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㧳㧚⎇ⓥ⊒⴫  ߥߒ ታ↪ᣂ᩺⊓㍳ߥߒ

145 ߘߩઁߥߒ

146