INSTITUTE OF TROPICAL MEDICINENAGASAKI UNIVERSITYTE

OF TROPIC

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through Scientific Discovery and its Application Solving the World Health Problem

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2016

MISSION STATEMENT
Institute of Tropical Medicine (ITM), Nagasaki University
The tropics, the most ecologically diverse region on the Earth, presents an ongoingcomplexity of tropical diseases and other health problems. In view of the remarkableadvances made in the field of international exchange in recent years, it is imperative thatthese problems be addressed from a global perspective.
Based on this understanding, the Institute of Tropical Medicine, Nagasaki University,
aims to overcome tropical diseases, particularly infectious diseases, and the various healthproblems associated with them, in cooperation with related institutions, to strive forexcellence in the following areas:
1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotionin the tropics by applying the fruits of the research
3. Cultivation of the researchers and specialists in the above fields

General View of the Institute

Coverpage Photo : Lake Victoria in Kenya (by Shinjiro Hamano, Department of Parasitology)Preface
Nagasaki University Institute of Tropical Medicine (ITM) was established in 1942 as a unique government-assisted
institution for research on tropical medicine, both in the basic and applied fields. The Ministry of Education, Culture,
Sports, Science and Technology (MEXT) designated ITM as a “Collaborative Institute” and a “Center of Excellence” in1982 and 1995 respectively. In 1993, the World Health Organization designated ITM a WHO Collaborating Centre for
Reference and Research on Tropical Viral Diseases. Most recently, in 2009, ITM was authorized as a “Tropical
Medicine Research Center of Joint Usage” supported by MEXT, This recognition underlines the importance of ITM as
an open institute whose resources are freely available to the whole research community. The current organization of
the institute involves four major research fields (15 departments, one domestic visiting department, one overseas
visiting department), two centres, and one clinical unit.

Developing countries in the tropics, the most ecologically and culturally diverse regions of the world, are affectedby a diverse group of tropical diseases, new emerging infectious diseases and life-style diseases. In view of theremarkable advances made in the field of international exchange in recent years, the industrialized countries of thetemperate zones are also affected by these problems and it is imperative that they are addressed from a global
perspective. Based on this paradigm, ITM aims to overcome tropical and emerging infectious diseases, and thevarious related health problems in the tropics and the rest of the world, in cooperation with related institutions, and to
strive for excellence in the following areas:

1. Spear-head research in tropical medicine and international health
2. Global contribution through disease control and health promotion in the tropics by applying the fruits of theresearch
3. Cultivation of the researchers and specialists in the above fields

This pamphlet offers a brief but hopefully intelligible explanation of our organization and its activities in research,education and other related social activities. As you will see, our research activities address traditional tropicaldiseases such as malaria, schistosomiasis, dengue fever, yellow fever and acute respiratory infections, and emerging
infections such as HIV/AIDS, SARS and Ebola disease. We conduct basic, epidemiological and clinical research fordisease prevention and control. We also investigate environmental factors including vectors, and natural and social
environments. ITM educates students in PhD and Masters courses as part of the Graduate School of Biomedical
Science and Graduate School of Tropical Medicine and Global Health of Nagasaki University. In addition, ITM provides
a three-month training course on tropical medicine. You will also find information about our research bases in Kenya
and Vietnam. Finally, the financial status of the institute is summarized.
Your suggestions, support and ideas for the further development of ITM are greatly appreciated.
May, 2016
Kouichi Morita
Dean and Professor
Institute of Tropical Medicine (ITM)
Nagasaki University― 1 ―Contents
Preface ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Contents ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Historical Review ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Successive Deans of the Institute ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Organizational Chart ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Research Center on Tropical Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Character of research organization and activities ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Graduate Courses ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Three-month Course on Tropical Medicine ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Public communication ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Publications ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Virology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Emerging Infectious Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Bacteriology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Protozoology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Parasitology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Immunogenetics ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Pathology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Eco-epidemiology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of International Health ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Vector Ecology & Environment ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Clinical Medicine ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Pediatric Infectious Diseases ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Department of Clinical Product Development ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Vietnam Research Station ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Tropical Medicine Museum ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Central Laboratory ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
NEKKEN National BioResource Center ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
LF-NTD Unit ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥The University Hospital Infectious Disease Ward ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Number of Staff ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Accounting ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Grant-in-Aid for Scientific Research from the Ministry of Education,
Culture, Sports, Science and Technology ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Grant-in-Aid for Scientific Research from the Ministry of Health, Labour and Welfare ‥‥‥‥
Subsidy ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
External Fund‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Agreement of Educational, Scientific and Scholarly Exchange ‥‥‥‥‥‥‥‥‥‥‥‥‥
Telephone Number ‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥‥
Location map of the Institute of Tropical Medicine on Sakamoto Campus of Nagasaki University ‥

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Historical Review
The Institute of Tropical Medicine, Nagasaki
University was originally founded in March 1942 as theEast Asia Research Institute of Endemics, Nagasaki
Medical College in order to perform basic and appliedstudies on endemic diseases in East Asia. At the
beginning, most of its research activities were fieldstudies conducted in mainland China by the
Departments of Pathology, Bacteriology, Internal
Medicine, and Dermatology of Nagasaki Medical
College. August 9th, 1945, the atomic bomb was
dropped in Nagasaki, and the Institute's all the facilities
and research materials were completely destroyed
together with Medical School. Consequently, thedevelopment of the Institute and its research activities
had lagged significantly behind.
In April, 1946, the Institute changed its name to
the Research Institute of Endemics, Nagasaki Medical
College, and moved to Isahaya City in May to resume
research activities. Yet in accordance with the National
School Establishment Law issued in May, 1949, theInstitute once again changed its name to the ResearchInstitute of Endemics, Nagasaki University. In 1957, theInstitute was affected by another disaster of massive
flooding, and its facilities, equipment, and researchmaterials were severely damaged. Thus, constructionof a new building started in Sakamoto, Nagasaki City in
1960, and the Institute moved to the building in April ofthe following year. The Institute's Departments, whichwere only two at the time, Pathology and Clinics,
increased its number every year after 1963, including
Epidemiology, Parasitology, and Virology. The
Sakamoto building finished its first expansion at theend of 1966.
In June, 1967, with the partial alteration of the
National School Establishment Law, the name of theInstitute was changed for the third time to the present
one to carry out basic and applied studies on tropical
medicine. Around the same time, the Department ofInternal Medicine, Institute of Tropical Medicine,
equipped with 20 beds, was opened in the University
Hospital. In 1974, the Department of Bacteriology andthe Reference Center were attached, and in 1978, theDepartment of Preventive Medicine, consisting mainlyof visiting professors, associate professors, andresearchers, and the Tropical Medicine Training Course

were launched. In the ensuing year, the Infectious
Animals Depriva-tion Experiment Laboratory was
promoted to be-come the Animal research Center for
Tropical Infections, and the second building expansion
was concluded in March, 1980. In September, 1983, a
JICA-sponsored group training program Tropical
Medicine Research Course was opened, theDepartment of Protozoology was established a year
after, and the third building extension was finished inJuly the year after that. Two years later, the Departmentof Medical Entomology was created and the Institutewas reorganized into the collaborative institute inanother two years. In 1991, the Department ofBiochemistry was added, and the fourth building
expansion was ended in March, 1994. In April, 1994,
the Institute was divided into three big Divisions,Tropical Microbiology, Pathogenesis and Clinical
Sciences, and Environmental Medicine, with theestablishment of two new research Departments,
Thermal Adaptation and Social Environment, whichhave expanded to 12 Departments at present. The
Institute was desig-nated as Center of Excell-ence inthe forefront of scientific research in 1995, and a newresearch Department, Molecular Epide-miology, wasestablished under the Research Field of Microbiology in1996 to invite overseas visiting professors. In 1997, theReference Room for the Tropical Medicine was
replaced by the Tropical Disease Information andReference Center, and it was again succeeded by the
Research Center for Tropical Infectious Disease in
2001. In March, 2003, when the Sakamoto build-ing
finalized its fifth expansion, its extension work of almost
40 years came to an end. In March, 2006, the mainbuilding's repair work was completed. In April, 2008,
the Research Center for Tropical Infectious Disease for
the Tropical Medicine was replaced by the Center for
Infectious Disease Research in Asia and Africa andTropical Medicine Museum. In June, 2009, the institute
was authorized as the Collaborative Research Center
on Tropical Disease by the Ministry of Education. Morerecently, three additional depatments i.e., clinicalmedicine, pediatric infectious diseases and clinicalpharmaceutical science, were admitted for installation.
In June, 2013, the Animal Research Center for
Tropical Infections was closed.
In April, 2014, Tropical Medicine Museum was
relocated.

― 3 ―Successive Deans of the Institute（East Asian Research Institute of Endemics）
Susumu Tsunoo

M a y.

Kohei Koyano

D e c . 22, 1945 - Jan. 23, 1948

Kiyoshi Takase

J a n . 24, 1948 - Aug. 31, 1948

Noboru Tokura

Sept. 1, 1948 - May. 30, 1949

4, 1942 - Aug. 22, 1945

（Research Institute of Endemics）
Noboru Tokura

M a y. 31, 1949 - Aug. 31, 1958

Nanzaburo Omori

Sept. 1, 1958 - Nov. 30, 1963

Hideo Fukumi

Dec. 1, 1963 - May. 31, 1967

（Institute of Tropical Medicine）
Hideo Fukumi

Jun.

Daisuke Katamine

D e c . 1, 1969 - Nov. 30, 1973

Kaoru Hayashi

Dec. 1, 1973 - Nov. 30, 1977

Tatsuro Naito

D e c . 1, 1977 - Nov. 30, 1979

Daisuke Katamine

D e c . 1, 1979 - A p r. 01, 1981

Keizo MatsumotoA p r.

2, 1981 - A p r. 01, 1991

Hideyo Itakura

A p r.

2, 1991 - A p r. 01, 1993

Mitsuo Kosaka

A p r.

2, 1993 - A p r. 01, 1997

Akira Igarashi

A p r.

2, 1997 - May. 31, 2001

Yoshiki Aoki

A p r.

1, 2001 - May. 31, 2007

Kenji Hirayama

A p r.

1, 2007 - May. 31, 2011

Tsutomu Takeuchi

A p r.

1, 2011 - May. 31, 2013

Kouichi Morita

A p r.

1, 2013 - Up to the present― 4 ―1, 1967 - Nov. 30, 1969

Organizational Chart
Department of Virology
Microbiology
and Parasitology

Department of Emerging Infectious Diseases
Department of Bacteriology
Department of Protozoology
Department of Parasitology
Department of Molecular Epidemiology(Overseas Visiting Professor)
Department of lmmunogenetics

Host and Vector
Biology

Department of Host-Defense Biochemistry
Depanment of Pathology
Department of Preventive Medicine and AIDS Research
Department of Eco-epidemiology

Management
Meeting

Public andEnvironmental Health

Department of International Health
Department of Global Health Development Policy Sciences
Department of Vector Ecology and Environment

Dean
Faculty
Meeting

Clinical Medicine
and Research

Department of Clinical Medicine
Department of Pediatric Infectious Diseases
Department of Clinical Product Development
Center for Infectious Disease Research in Asia and Africa
Kenya Research Station

AssociatedFacilities

Vietnam Research Station
Tropical Medicine Museum
Central Research Laboratory
Office for Training and Education
National BioResource Center
LF-NTD Unit
NTDs Innovation Center
Humanitarian Assistance Coordination Office

Nagasaki
University
HospitalInternal Medicine

Department of Infections Diseases― 5 ―Research Center on Tropical Diseases
Our institute is the one and only public sector
supported by MEXT (Ministry of Education, Culture,
Sports, Science and Technology, Japan) that aims todo the research on tropical diseases, and identified as
the Collaborative Research Center on Tropical
Disease.

through exchanging information or technologies
necessary. The Research Center on Tropical Medicine
is also to deliver bio-resources including infectious
agents, information, and etc. collected and stored
here, and thus serves as a resource center on Tropical
Medicine.

1. The Goal of the Center
The infectious diseases are caused by thecollapse of symbiosis with other creatures, whichcannot be avoided if we, human being, live in thenature. Although the ultimate aim of this center is toeradicate infectious diseases, it is needed rather toestablish reciprocal relationship with other creatures
than to eliminate them. Such establishment ofreciprocal relationship requires the collective
knowledge, which can be achieved only by combining
a broad aspect of disciplines.
The Tropical Infectious Diseases have been
spreading in the tropical area, which is the reflectionof environment and socio-economic situation existed
there. It is considered to be a big challenge related tohealth. As a matter of fact, emerging and re-emerging
infectious diseases including newly emerging
infectious diseases, HIV and tuberculosis have been
spreading globally with tropical area being its
epicenter. The tropical area is not only the battle field
where we, human being, fight against them but also
the experimental ground where we newly create anddevelop our knowledge and technology alike in order
to control infectious diseases.
The Research Center on Tropical Diseases is toaccomplish with the members in the diverse scientificcommunities collaborative researches rooted upon thefield where infectious diseases are prevailing, making
use of the facilities like Asia and Africa Research
Stations internationally recognized. It also serves as aresource center for information and biological samples
related to infectious diseases speeding globally.

3. Organizational Chart of the Center
As for administration of this research center, thedean of the Institute of Tropical Medicine establishedthe Steering Committee for the Collaborative
Research Center on Tropical Medicine, which wascomposed of 11 members, out of whom more thanhalf should be outside the university concerned. The
Steering Committee for the Collaborative ResearchCenter on Tropical Medicine is responsible for
adoption of the applications and monitoring andevaluation of the activities in question.
In order to support activities above mentioned,
the specific section supporting the Research Center
on Tropical Medicine was newly formed and aprofessor was designated to be a section chief.
4. Applications for Collaborative Researches
There were 28 applications for collaborative
researches, out of which 23 were adopted.
There were 2 applications for collaborative
researches with overseas bases, out of which 2 wereadopted.
There were 2 applications for research meeting,out of which 2 were adopted.

2. Outline of the Collaborative Research
The Research Center on Tropical Medicine
appeals to the public for the collaborative research,which is either basic or applied research based uponepidemiological, clinical or public health framework.
The Research Center on Tropical Medicine appeals tothe public for the research meeting, which promotes
and facilitates the research of infectious diseases― 6 ―Concept Diagram
The Institute ofTropical Medicine

The Tropical Medicine
Research Center Committee

Researchers' Communities

Dean

Discuss important matterson its management

Send a delegate/delegates as amember of the committee to address
opinions from communities

Advice / Report

Expert advisors
Discuss specialized mattersthat are inquired

The Tropical Medicine
Research Center Office
Support for its management and follow
the intention of the committee― 7 ―Research Grants
A collaborative Research Topic
A collaborative Research Topic
A collaborative Research Topic

Character of researchorganization and activities
Based on the following research organization andintimate linkages with other research institutes anduniversities, the institute aims at accomplishing a
mission: Spear-head research in tropical medicine andinternational health.
●To study comprehensively the tropical diseases
which are raging in the developing countries,
research organization of the institute consists of 4
major research fields which deal with the classic
quad of the human-agent-environment determinantclinical study of infectious diseases and Overseas
Research Station and Tropical Medicine Museum.
Other facilities of the institute include a joint researchlaboratory and a tropical medicine education office.
●The research of tropical medicine faces theinevitable fact that the bench is in the bush.
Therefore the institute has a close linkage with theoverseas institutes in Asia, Africa and SouthAmericas and continues the joint studies.
Memorandums of academic exchange programs
were signed between Nagasaki University and 14
overseas institutes. Since the overseas researchlaboratories of the institute has been established in
Kenya Medical Research Institute (KEMRI), Kenya
and National Institute of Hygiene and Epidemiology(NIHE) Vietnam in 2005, by the grants from Ministryof Education, Sports, Culture, Science andtechnology (MEXT), the extensive and longitudinalstudies on tropical diseases has been on the
progress, and are extended to continue in more 5 or
6 years. The third term of the Vietnam project has
started in 2015 and Kenya project has started in2016. We have extended our effort to achieve
external funds for this project and obtained theSpecial Coordination Funds for Promoting Scienceand Technology and the Science and Technology
Research Partnership for Sustainable Deve-lopment(SATREPS), etc. These funds have expanded theresearches at Asia and Africa stations.
●The prevalence of tropical diseases depends on thegeographic, social and economic factors. Therefore
the institute has established the special researchsystem which helps forward the multidisciplinary
studies on tropical diseases.

Graduate Courses
1. PhD Course
In April 2002, the structure of doctoral course in
Nagasaki University was re-organized by integrating
the three graduate schools from the Schools of
Medical Science, Dental Science and Pharmacology
into the Graduate School of Biomedical Sciences. The
schoo now offers six master and doctoral courses. All

the departments in the Institute of Tropical Medicine(ITM) are involved in teaching the Course on Infection
Research. In April 2013, the “Program for Nurturing
Global Leaders in Tropical and Emerging
Communicable Diseases (PhD course)” wasincorporated in this course. Limited to 15 students per
year, the new program is one of the several programs
adopted by the Program for Leading Programsupported by the Ministry of Education, Culture,
Sports, Science and Technology. It focuses oncontrolling tropical and emerging infectious
communicable diseases and on leadership. One of its
unique features is that students will be given practicaltrainings in a cross-field curriculum, which includes
hands-on training at overseas Nagasaki University
Research Stations in Kenya and Vietnam and otherinternational organizations. In addition, 20 staff of ITM
composed of professors, associate professors andassistant professors participate in this program. They
play an important role in giving lectures related totropical and emerging communicable diseases and in
helping students to write their dissertations.
2. Master Courses
In April 2015, School of Tropical Medicine andGlobal Health was newly established.
The School consists of three master courses;
Tropical Medicine Course (Master of Tropical Medicine)
will provide the medical doctors with clinicalknowledge and academic research skill to respond tohealth issues in the area of tropical medicine.
International Health Development Course (Master of
Public Health) will equip the students with essential
knowledge and skills required to pursue careers ininternational health.
Health Innovation Course (Master of Science in Global
Health and Medicine) will give opportunities of basic
research skills to prepare for pursuing higher academic
careers in global health research. The latter two
courses are open to those who have no medical/
health background.
One of the strengths is that the students of all threecourses will learn together in the basic modules on
global health so that they will have opportunities tounderstand the issues in wider perspectives than theirown disciplines.
Other characteristics include that all the lectures are
conducted in English and that we are closely engagedin academic partnership of teaching and research with
London School of Hygiene & Tropical Medicine, aleading global institute of tropical medicine
The information on these courses including application
form will be available through our webpage.
http://www.tm.nagasaki-u.ac.jp/nekken/english/index.html― 8 ―Three-month Course on
Tropical Medicine
This is a short-course of tropical medicine. This
course aims to support medical and co-medical
personnel who plan to work in the tropics, byproviding opportunities to learn a broad range ofskills and knowledge relevant to practicing medicine,
implementing disease control programs andconducting medical research in tropical anddeveloping countries. The course began in 1978.
Fifteen participants are accepted to attend thecourse in each year. As of the 38th course in 2015,
488 participants in total (including 192 medical
doctors, and 296 co-medical such as nurses,
community health nurses, midwives, pharmacists)from all over Japan have completed the course. The
course is run by the steering committee, which
consists of members from both inside and outside
the Institute of Tropical Medicine (ITM).
The full-time staff members of the ITM and asubstantial number of visiting professors andlecturers provide the 13 weeks (April to June) oflectures, laboratory practicals and field work in thefields of virology, bacteriology, protozoology,
parasitology, medical entomology, pathology,
immunogenetics, epidemiology, human ecology,social medicine, clinical medicine and also
geography and culture in tropics. Participants who
successfully completed the course are awarded the
Diploma in Tropical Medicine.

Culture etc. To accumulate know-how of risk
communication on tropical infectious diseases in our
institute, we are planning to have open lectures
where we have frank communication with citizens on
the present state and future prospects of researchon tropical medicine.

Publications
Our official publications are as follows;
1. Bulletin of Nagasaki University Institute of Tropical
Medicine (in Japanese, yearly since 1964, PDF
files are available at our web page.)
2. Japanese Brochure (in Japanese yearly since1977, PDF files are available at our web page.)
3. English Brochure: INSTITUTE OF TROPICALMEDICINE NAGASAKI UNIVERSITY (this copy.
Yearly since 1977, PDF files are available at our
web page.)
4. Report of Nation-wide Cooperative Research
Projects (Information of research activities andachievements as a nation-wile cooperative
research center for tropical medicine is compiled.)

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Admisssion ceremony in 2016

Public communication
Lectures and film shows for citizens are heldoccasionally. Every year, several groups of highschool students with teachers visit our museum,attending lectures and film shows. In 2015, we had
5 open lectures at Nagasaki Museum of History and― 9 ―Department of Virology
This Department has been conducting basic
and applied research on arthropod-borne viruses(arboviruses) such as Japanese encephalitis virus(JEV), dengue virus (DENV), Zika virus, Chikungunya
virus(CHIKV)andseverefever
withthrombocytopenia virus (SFTSV), as well as
emerging infectious viruses, such as SARS virus andNipah virus.
Molecular epidemiology of arboviruses
We isolate DENV, JEV and CHIKV in Asia andAfricanregionsandconduct
molecular
epidemiological analysis to clarify international andinter-continental movement of these viruses. We
also analyze unique genome sequences that are
relevant to pathogenicity.

Activities as a WHO Collaborating Center
The Department of Virology is designated as a
WHO Collaborating Center for Reference andResearch on Tropical Viral Diseases since 1993 andhas been re-designated until the present. The
Department has been collaborating with WHO in
training WHO fellows from many developing
countries and has deployed experts as WHO shortterm consultants. In addition, Dr. Kouichi Morita wasdispatched to WHO/WPRO as Regional Adviser on
Communicable Diseases from 16 May 1995 to 15
May 1998. Dr. Futoshi Hasebe was also dispatchedto WHO for a long term to collaborate in the global
emerging infectious disease control program fromMarch 2004 to March 2006. The Department
initiated and held the First GOARN/WHO National
Training Course in Nagasaki from 25 to 29 February
2008 in collaboration with WHO/WPRO.

Research on viral pathogenesis and vaccine
development using reverse genetics
We have developed infectious clones of JEV
and DENV and identified gene functions bymodifying various parts of the genes or constructing
chimeric viruses. In addition, we are developing
genetically engineered viruses as candidates for live
attenuated vaccines.
Research on the pathogenicity of arboviruses and invivo evaluation of therapeutic compounds
We elucidate the mechanism of pathogenicity
and infectivity of arboviruses, such as JEV and
SFTSV using a mouse model. We also evaluate thetherapeutic effects of antiviral drugs and antiserum invivo.
Development of rapid diagnostic assay for infectious
diseases
Various tools for rapid diagnoses are being
developed for flaviviruses and other emerging
viruses using PCR, LAMP and nLC/MS
technologies. Also, genetically engineered antigens
are being developed to provide affordable
serological tests for developing countries.
Research on emerging viral infectious diseases
Epidemiological studies on SARS virus, Severe
Fever and Thrombocytopenia Syndrome virus (SFTS)
and H5N1 avian influenza virus are being conductedin Viet Nam, Japan and other countries in the South
East Asia.

― 10 ―

Professor
Professor (Project)
Associate Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Visiting Professor
Visiting Professor
Visiting Researcher
Visiting Researcher
Visiting Researcher
Research Fellow
Research Fellow
Research Fellow
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Kouichi Morita
Futoshi Hasebe
Moi Meng Ling
Daisuke Hayasaka
Shingo Inoue
Fuxun Yu
Takeshi Nabeshima
Buerano Corazon Cerilla
Masanobu Ago
Toru Kubo
Yuki Takamatsu
Reo Uchida
Mya Myat Ngwe Tun
Muhareva Raekiansyah
Mitsuru Toda
Kazumi Jodai
Ulanday Gianne Eduard Limbo
Adungo Ferdinard
Aung Kyaw Kyaw
Satoshi Shimada
Phu Ly Minh Huong
Bui Thu Thuy
Mark Anthony D. Luz

Molecular imaging of SFTSV-infected mouseDepartment of Emerging
Infectious Diseases

to control infection and to prevent furthertransmission. We have developed novel diagnostic
assay for emerging viral diseases.

Emerging infectious diseases are infectious
diseases whose incidence in humans haveincreased in the past 20 years and threaten toincrease in the near future. We are working on thebasic research to develop and produce
countermeasures against emerging infectious
diseases, especially viral hemorrhagic fevers andinfluenza.

Studies on Lassa fever in Nigeria
Lassa fever is a viral hemorrhagic fever and now
endemic in West African countries. Annually
300,000-500,000 peoples are infected with Lassa
virus and 5,000 patients have died in Lassa fever
every year. We are carrying on the epidemiologicalstudies, the development of novel diagnostic
methods and the pathological studies on Lassa
fever in collaboration with a Nigerian group.

Research subjects:
Analyses of replication mechanisms of highly
pathogenic viruses
In infected cells, the viruses replicate using
various cellular machinery and release a large
number of progeny virions. Our interests are toclarify the molecular mechanisms of virus replication
in host cells. We are currently analyzing themolecular interactions between viral proteins andcellular factors in virus infected cells. Especially, we
are focusing on highly pathogenic viruses, such as
Ebola, Marburg, Lassa and Influenza viruses.
Development of novel antiviral strategies
To establish novel antiviral strategies against
viral hemorrhagic fevers and influenza, we are
identifying the cellular factors which have antiviral
activity and analyzing the molecular mechanisms of
their antiviral action. We will also start highthroughput screening of organic and chemicalcompound libraries for antiviral drug discovery
against viral hemorrhagic fevers.

Studies on endogenous retroviruses
Recently, it has been reported that a portion oflive attenuated vaccines for pets, which were
produced using mammalian cell lines, were
contaminated with infectious endogenous retrovirus.
Furthermore, in therapeutic use of animal cells,
tissues, and organs derived from pigs as donors forxenotransplants, a major international concern is thepossibility of cross-species transmission of infectious
porcine endogenous retrovirus from animal donor to
immunosuppressed human transplant patients. To
reduce the risk induced by endogenous retrovirusesin vaccine preparation and xenotransplantation, weare developing the strategies to regulate theproduction of endogenous retroviruses from cells.

Development of detection methods for highly
pathogenic viruses
In case of outbreak of emerging infectious
diseases, rapid and accurate diagnosis is essential

Molecular Mechanism of Marburg virus budding

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Research Fellow
Research Fellow
Research Assistant
Assistant
Graduate Student

Jiro Yasuda
Yohei Kurosaki
Shuzo Urata
Haruka Abe
Yuri Ushijima
Sayaka Okada
Mayuko Kimura
Tomomi Kamiyama
Olamide Oloniniyi

Collaboration research work in the South Africa
BSL-4 facility― 11 ―

Department of Bacteriology
Our major research interest is to elucidate the
etiologic agents isolated from pathogenic bacteria
related to the worldwide emerging and reemerging
diseases and to know the virulence mechanisms ofbacterial pathogens.
Helicobacter pylori is a bacterial pathogen found in
the stomach mucosa of more than 50% of the world
population and more common (over 80%) in developing
and tropical countries. Infection with H. pylori plays amajor role in the development of chronic gastritis andpeptic ulcer, and is a risk factor for gastric cancer.
Pathogenic strains of H. pylori secrete a potent protein
toxin, a vacuolating cytotoxin, termed VacA, whichcauses progressive vacuolation of epithelial cells andgastric injury. We found that VacA induces multiple
effects on epithelial cells, including mitochondrial
damage [1] and apoptosis [2]. These actions of VacA
appear to result from activation of cellular pathways,
independent of those leading to vacuolation. Similarly,
VacA-induced phos-phorylation of G proteincoupled
receptor kinase-interactor 1 (Git 1), which may be
responsible for epithelial cell detachment caused by
VacA, leading to peptic ulceration [3], and VacAinduced activation of p 38/ATF-2- mediated signal
pathway [4] are independent of VacA effects on cellularvacuolation.
Analysis of VacA receptors provided new insights
into the molecular basis of VacA function. We reported
that two VacA proteins, termed m1 VacA and m2 VacA,
which were defined by sequence differences in the
middle of the molecules, interacted with target cells bybinding to two types of receptor-like protein tyrosine
phosphatases (RPTPs), i. e., RPTPα and RPTPβ,resulting in toxin internalization and vacuolation of thehuman gastric adeno-carcinoma cell lines AZ-521 andG 401 [5, 6, 7]. By analysis of the pathologicalresponses of wild type and RPTPβ-deficient mice tooral administration of VacA, we found that RPTPβ
functions as a receptor for VacA and produces thedisease associated with VacA toxicity including gastritis
and gastric ulcer [3].
More recently, we purified from AZ-521 cells, ahuman gastric epithelial ell line, a surface membraneprotein, p500, which binds VacA, and identified it as
low-density lipoprotein receptor-related protein-1(LRP1). LRP1 binding of VacA was shown to be
specifically responsible for VacA-induced autophagy
and apoptosis, but not activation of the Wnt/β-cateninsignaling pathway. Similar to RPTPα and RPTPβ,
LRP1 mediates VacA internalization in AZ-521 cells, but
in contrast to RPTPα and RPTPβ, LRP1 targeted
downstream pathways leading to autophagy andapoptosis. VacA-induced autophagy via LRP1 binding
precedes apoptosis suggesting that an excessive
autophagic activity can also lead to cell death. This is
the first study to provide evidence that LRP1 mediates
autophagy [8]. Surprisingly, CagA, which is an
oncogenic protein injected by its type IV secretion
system into host cells, was degraded by autophagy
induced by m1 VacA, but not m2 VacA, whereas CagA
in CD44v9-expressing cancer stem-like cells escaped
this autophagy system, resulting in accumulation of
CagA in cells [9].
References:[1] Microb. Pathog. 31:29-36, 2001,[2] J. Biol. Chem. 281: 11250-11259, 2006,[3] Nat. Genet. 33: 375-381, 2003,[4] J. Biol. Chem. 279: 7024-7028, 2004,[5] J. Biol. Chem. 278:19183-19189, 2003,[6] J. Biol. Chem. 279: 51013-51021, 2004,[7] Cell Microbiol 7: 1285-293, 2005,[8] J. Biol. Chem. 287:3104-3115, 2012,[9] Cell Host Microbe. 12: 764-777. 2012.

Virulence mechanism of Helicobacter pylori
vacuolating cytotoxin, VacA

Senior Assistant Professor
Assistant professor
Assistant

Akihiro Wada
Masayuki Nakano
Yoshiki Tsutada

Laboratory― 12 ―

8) Establishment of a novel malaria model using
ungulate Plasmodium

Department of Protozoology
Malaria is responsible for a huge burden ofdeath and disease in large areas of the tropical andsub-tropical world. Unfortunately, those countries
hardest hit by the disease are often amongst thepoorest. Despite continuing efforts, there is still noeffective vaccine against the disease. In order todesign and implement effective disease intervention
strategies, we believe that one of the key priorities inmalaria research should be the strengthening of ourunderstanding of the basic biology of the parasite.
We are currently investigating some fundamental
aspects of the parasite’s life cycle, such as themechanisms behind red blood cell (RBC) invasion
and the phenomenon of cytoadherence of parasiteinfected RBCs using a variety of malaria parasites
including human-infecting Plasmodium falciparum,rodent malaria parasite Plasmodium yoelii, andPlasmodium knowlesi a causative agent of zoonotic
human malaria. To expand a platform for basic andclinical malaria researches, we also aim to establish
novel malaria model systems for Plasmodium vivax
and ungulate malaria parasites. In addition, we arealso conducting research aimed at elucidating theintracellular survival strategy of Trypanosma cruzithat cause Chagas disease and Babesia parasitesthat cause Babesiosis in cattle.

2. Trypanosoma
1) The function and expression mechanism of transsialidase
2) Stage specific adaptation mechanisms employedby different Trypanosoma species
3. Babesia
1) Molecular basis of host cell invasion andmodification
2) Development of genetic manipulation techniques
for Piroplasm parasites

We are actively pursuing the following lines ofinvestigation:

Professor
Osamu Kaneko
Senior Assistant Professor Haruki Uemura
Assistant Professor
Kazuhide Yahata
Assistant Professor
Masahito Asada
Research Fellow
Shinya Miyazaki
Research Fellow
Kittisak Thawnashom
Research Fellow
Mika Takeda
Assistant
Reiko Tanaka
Assistant
Miki Kinoshita
Assistant
Sachie Takahama
AssistantNana Matsumoto
Graduate Student
Amuza Byaruhanga Lucky
Graduate Student
Yuto Kegawa
Graduate Student
Kwame Kumi Asare
Graduate Student
Ben-Yeddy Abel Chitama
Graduate Student
Takahiro Ishizaki
Visiting Researcher (JSPS) Hassan Hakimi
Visiting Researcher
Fumihiko Kawamoto

1. Malaria
1) The molecular basis of host cell invasion byparasites
2) The molecular basis of cytoadherence of parasiteinfected RBCs
3) Calcium signaling in malaria parasites
4) Molecular epidemiology of malaria parasites inendemic countries5) Understanding the biology of Plasmodium vivax
hypnozoites
6) Establishment of a reporter line of Plasmodium vivax7) Molecular basis of human Plasmodium knowlesi
infection

P. falciparum expressing a calcium biosensor. Fluorescenceresonance energy transfer (FRET) signal from the same
parasite is shown in pseudocolor before (left) and after(right) adding an inhibitor of calcium-dependent ATPase.

RBC invasion by P. yoelii. Merozoite-stage parasite(arrowhead) invades into RBC within 30 seconds (0 - 25 s)
and deformed RBC to spike-like shape (85 s).

Recombinant protein (green) expressed in P. falciparum
co-localized with Maurer's cleft protein (red) seen in the
RBC cytosol outside of the malaria parasite. Nucleus isvisualized with blue color.

― 13 ―

Department of Parasitology
Infectious diseases are still a huge menace tohuman health and continue unabated in tropicalareas under the conditions of poverty and theunique natural and social environments. Various
kinds of parasites infect humans for long periods oftime without killing them, giving rise to tremendous
afflictions, social and/or economic loss. We would
like to develop deep insight into parasitic diseases
and the surrounding factors from various points ofview through both field and laboratory studies. Our
goal is to contribute to new knowledge and toprovide an enthusiastic environment for the trainingof the future generation of investigators.
Target diseases of our studies
We have been carrying out both field andlaboratory studies on several of the most importanthelminthic diseases, including schistosomiasis,
filariasis and intestinal helminthiasis and on importantbut neglected protozoan diseases such asamebiasis, leishmaniasis and trypanosomiasis.

Fund (GHIT) last year. In addition, we developed
animal models of intestinal amoebiasis together with
Prof. Houpt at University of Virginia, we elucidated
the pathogenicity of Entamoeba moshkovskii, andnow are devoting ourselves to the study onmolecular basis of pathogenicity of and host defense
mechanisms to E. histolytica.
3. Cohort study using HDSS on infectious diseases in
Mbita and Kwale area in Kenya
We are repeating cross-sectional study on
infectious diseases including shistosomiasis, otherhelminthic and protozoan infections, Malaria,
tuberculosis and so on, in Mbita and Kwale area
using HDSS (Health and Demographic Surveillance
System) as the collaboration with London School,
Niigata Univ. and Dept. Vector Ecology andEnvironment,
Immunogenetics
andEcoepidemiology.

1. Schistosomiasis and Filariasis
We have been researching parasitic diseases in
Mbita and Kwale, Kenya, in cooperation with Kenya
Medical Research Institute (KEMRI). In thelaboratory, we maintain Schistosoma mansoni andintermediate snails and are trying to elucidate
immune responses as well as to develop ideal
diagnostic methods through the study on the uniquemolecules belonging to Schistosoma spp.
We set up lymphatic filariasis and neglected
tropical disease unit (LF-NTD Unit) together with
Prof. Kazuyo Ichimori, so as to contribute to theactivities toward Global Program to Eliminate LF and
NTD by WHO. In the laboratory, Brugia malayi, B.
pahangi and Aedes aegypti are maintained.
2. Amebiasis, Leishmaniasis, Trypanosomiasis etc.
Cohort studies on amoebiasis and leishmaniasis
are carried out in cooperation with the International
Centre for Diarrheal Disease Research, Bangladesh(ICDDR, B.) and the University of Virginia. Field sites
include Dhaka and rural areas of Bangladesh. In thelaboratory, we study host defense mechanisms
againstLeishmania
major,
L.
donovani,
Trypanosoma cruzi, and in the process, haveelucidated the function of the IL-12 cytokine familysuch as IL-27/WSX-1 during infection. We initiateddeveloping the vaccine to leishmaniasis with thesupport from Global Health Innovative Technology― 14 ―

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Research Fellow
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Technologist
Assistant
Assistant
Assistant
Assistant

Shinjiro Hamano
Yoshinori Mitsui
Kentaro Kato
Risa Sonoda
Lam Quoc Bao
Shumpei Kambe
Kenichi Nobusue
Taeko Moriyasu
Sharmina Deloer
Evans Asena ChadekaMusa Abu Mohamed
Khanjada Shahnewaj Bin Mannan
Mitsuko Hasegawa
Megumi Hamasaki
Hiromi Oda
Fumie Hara
Yasuko Kawabata
Chiaki Hisata

Our field site in Kenya

* HLA, Mast Cell derived factors, related toseverity
2) Early stage predictors for severe Dengue fever* Free DNA, Chymase, VEGF ATⅢ

Department of Immunogenetics
This department is focusing on the pathogenic
genetic factors of the host and the parasite in themost important tropical infectious diseases by using
immunology and genetics.
Research activities:
To clarify the molecular mechanisms in theprotective and/or pathogenic host response tohuman pathogens such as Dengue virus, Malaria,
Trypanosoma cruzi and Schistosoma, the following
research projects are going on in our laboratory.
1. Malaria
1) Genetic analysis of malaria endemicity
2) Vaccine development* Py Transamidase (TAM) vaccine with nanoparticle delivery system
2. Schistosomiasis
1) Vaccine and Drug target molecules identification
by genomics and proteiomics* SEA motif bearing gene family
3. Chagas disease
1) Genetic susceptibility to different clinical typesof chronia Chagas disease, namely,indeterminate, cardiac, and digestive forms* HLA-B14 haplotype as resistant against
chronic complications2) Host and Parasite factors influencing on thereactivity to the chemotherapy in the paediatricpatients with chronia Chagas Disease. On
going3) Compound library screening by using in vitro
culture of T.cruzi* Astellas open innovation network including
U.Tokyo, Tokyo Institute of Technology,
AIST(National Institute of Advanced Industrial
Science and Technology), and DNDi
4. Dengue fever
1) Pathogenesis of the DHF(Dengue Hemorrhagic
Fever)

Members

Collaborations:
The research here is performed based on thewell-arranged collaborative projects with thefollowing facilities.
1. Malaria: Karolinska Institute (Sweden), Kenya
Medical Research Institute (KEMRI). London
School of Hygiene and Tropical Medicine,
University of Liverpool
2. Schistosmiasis: Jiangxi Provincial Institute ofParasitic Diseases (China), Jiangsu Provincial
Institute of Parasitic Disease (China), RITM
(Philippines).
3. Chagas Disease: Center of Tropical Medicine,
Sirani Clinic, and Hospital Japones (Bolivia), IICS
University of Asuncion (Paraguay).
4. Dengue Fever: Ho Chi Minh Pasteur in Vietnam,
Pasteur Paris, McMaster University
Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Technologist
Research Fellow
Assistant
Visiting Researcher
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Experiment scenery― 15 ―

Kenji Hirayama
Nguyen Huy Tien
(Clinical Product Development)
Cherif Mahamoud Sama
Shusaku Mizukami(Clinical Product Development)
Dumre Shyam Prakash
Tetsuo Yanagi (NBRC)
Chisato Narahara
Michiko Fukuda
Yukimi Katagami
Vasquez Velasques Clara Aleiandra
Dao Huy ManhFarhana MosadequeMathenge Peterson Gitonga
Maiko Akashi
Avenido Eleonor Fundan
Kota Mochizuki
Miho Inokuchi
Teklemichael Awet Alem

Fieldwork in Bolivia

Department of Pathology◯Division of Malaria◯Division of Pathology
Main purpose of our research is fundamentally
pathological investigation of tropical diseases, mainly
infectious diseases, focused on oncogenic
microbes, and establishes the basis of theirtreatment and prevention. Although many
investigators have proposed oncogenesis due to
inflammation associated cancer development, themechanisms underlying the relationship between
chronic inflammation and cancer still remainunresolved. Therefore, our research focuses on thepotential role of oncogenic microbes in thedevelopment of cancers, highlighting the recent
advances in the understanding of the molecularmechanisms.
The proportion of total cancer deaths
attributable to infectious agents is estimated to be
20% to 25% in developing countries and 7% to 10%
in industrialized countries. A causal relationshipbetween chronic inflammation and cancer is widely
accepted. Specifically, there is a strong association
between tumor viruses and the development of
human cancers. The mechanisms of oncogenesis
associated with infection and inflammation have notbeen elucidated. However, many oncogenic
mechanisms have been proposed for infection andinflammation. Activation of NF- B is also involved
cancer development and progression. Therefore, ourresearch focuses on the molecular players during
the development from chronic inflammation tocancer.

We are a small, highly driven malariology groupfocusing on many different aspects of malaria.
Established in 2011, we believe in a multidisciplinary approach to studying malaria, as thisenables a broad understanding of the subject, andtherefore facilitates the development of novel
solutions for fighting the disease. Such a holistic
approach to disease research can succeed only on
the foundation of a solid and detailed understandingof its multi-disciplinary constituents.
Our core belief is that all our research should
produce results that are of potential practical use forfighting the disease. We also strive to engage young
researchers in studies on malaria, and hope toencourage them to develop enthusiasm for usefulscientific research. Research should be fun, and wetry to foster a freethinking and engaging research
environment for students working with us.
We are interested in all aspects of malariology,
and are currently actively engaged in research
projects involving immunology, genetics, genomics,
evolutionary theory, ecology, epidemiology, andmolecular cell biology.
Collaborative projects with malaria researchers
based in Japan and internationally are of enormous
importance to us, and make up the bulk of the work
we are currently engaged in. At present we are
actively working with researchers from the USA, theRepublic of Congo, Vietnam, Sri Lanka, Australia,
Tanzania, Kenya, Nigeria, Brazil, the UK and Saudi
Arabia.
Associate Professor
Assistant Professor
Assistant― 16 ―

Richard Culleton
Masachika Senba
Sarina Hokama

Department of Eco-epidemiology
Our department is involved in various branchesof public health research. Through cutting edge IT
and biotechnology, we aim to create more accurate
assessment methods in global health, improve
responses to public health needs on a local scale,and open new directions in health science to passon to future generations. Our activities include thefollowing:1) Development of microsphere-based simultaneous
multiple assays and surveillance systems for
multiple infectious diseases in Africa. Neglected
tropical diseases (NTDs) are spreading across SubSaharan Africa, but the actual situation of NTDs is
still unclear. Simple and cost effective methods formonitoring NTDs are desirable, especially where
distributions of multiple NTDs are overlapping.
Toward this goal, we are developing a simultaneous
multiple antibody assay system, utilizing
microsphere-based multiplex technology. We arealso using the latest in IT for developing in-fieldsurveillance strategies.
2) Health and Demographic Surveillance System(HDSS) in Lao PDR. In many developing countries,
civil registration and vital statistics systems are still
deficient. Health and Demographic Surveillance
System (HDSS) is a resident registration system for
epidemiological research in a given locale. HDSS
follows residents and their dynamics over a longterm period. In Lao PDR, we are operating two
HDSSs to design research and improve healthconditions in rural communities.
3) Epidemiological studies for child health in
Kenya. Kwale district is categorized as one of thepoorest areas in Kenya. The infant mortality rate in
the region remains high. Poor nutritional status in
Kwale children contributes to a high prevalence ofstunted growth. To improve this situation, we areconducting a child cohort study, attempting to reveal
factors that could prevent stunted growth. A finger
vein recognition system, connected to tablet
computers is being utilized to facilitate follow-up
sessions with mother-child pairs.

problems in Sri Lanka, and measures of prevention
are urgently needed. We are evaluating the effects ofenvironmental intervention: e.g., clean-up activities
such as collection of containers left outdoors thatact as breeding sites for dengue mosquitoes (Aedes
aegypti and Ae. albopictus).
5) Finding malaria vaccine candidate antigens
using microsphere-based simultaneous multiple
assays. We are working to find novel candidate
antigens for malaria vaccine using a cohort in amalaria endemic area with a microsphere-based
multiplex assay system.
6) Ethnographic study on difficulties amongfamilies with infants in Tohoku, Japan. This study
utilizes ethnographic methods to record the current
difficulties and support needs among families with
infants in Rikuzentakata, one of the devastatedregions of the Great East Japan Earthquake.
7) A scientific approach to community-led total
sanitation strategies in Africa. The aim of this study
is to develop Community-Led Total Sanitation (CLTS)
models in Africa. We particularly focus on improving
community health through the promotion of toiletuse.
8) Non-communicable disease (NCD) project by
JICA in Sri Lanka. With increasing economic
development and longer life expectancy, the numberof lifestyle-related diseases, or non-communicablediseases (NCDs) is expected to increase. However, amechanism to grasp the actual situation of NCDs
does not currently exist in Sri Lanka. The
department has cooperated with the JICA NCD
management project to establish a system forestimating the number of patients with NCDs.

4) Research on dengue prevention through a
residential environmental clean-up program in Sri
Lanka. Dengue fever is one of the major health― 17 ―

Professor
Assistant Professor
Research Fellow
Research Fellow
Visiting Researcher
Visiting Researcher
Visiting Researcher (JSPS)
Assistant
Assistant
Assistant
Graduate Student

Satoshi Kaneko
Yoshito Fujii
Yombo Dan Justin Kalenda
Rie Ozaki
Tomoko Komagata
Kazuya Ogawa
Job Wasonga
Emi Nakayama
Kuniko Shimoda
Shiho Chikatoshi
Junichi Tanaka

Department ofInternational Health
Department of International Health has started
its activities since 2008, following the internal reformof Institute of Tropical Medicine. Department ofInternational Health has its basis on ResearchCenter for Tropical Infectious Diseases (RECTID) of
Institute of Tropical Medicine established in 2001,
Information and Reference Center in 1997, andReference Center in 1994.
It says that RECTID, a precursor of ourdepartment, had following three activities; 1)
developing the museum of tropical medicine, 2)collecting and disseminating information on tropicalinfectious diseases and 3) promoting joint research
projects and doing epidemiological studies. Out of
which, Department of International Health takes overresearch activities and adds to its mandate aninternational collaboration as a social responsibility
anew. Thus, Department of International Health, as a
newly established department, has two pillars, e.g.
research and social responsibility.
Research was composed of three units; 1)
research on infectious diseases in ecosystem, 2)
research on the environment including climatechange and Asian dust related to health, 3) researchon biological evolution of microorganisms from theadaptation or fitness viewpoint and 4) research on
the epidemiology from the historical viewpoint. The
umbrella concept or key word linking above four
research units is to reconstruct infectious diseases"temporally" and "spatially" alike. Infection is the
biological interaction between hosts andmicroorganisms. In other words, host behavior,social structure as well as culture per se affectmicroorganisms in fitness and adaptation whereas
microorganism has impact on its hosts. Based onthat perception, our department aims to get moredetailed understanding and insight on infectious
diseases. For examples, we would like to pursue theways of analysis by various approaches such as
molecular-evolutional
technique,molecular
epidemiology, detection of trace DNA, genomics
based on bioinformatics, mathematical model, andcomputer science. In addition to these researches ofinfectious diseases, we decided to add the historicalapproach based on documentary records in order tounderstand widely the relationship between
creatures and societies.
Another pillar is a social responsibility. Now thateven profit oriented organizations are required tohave its corporate social responsibility, no need tosay for academia or university. Out of the name ofour department, it must be nothing but contribution
to international health or people's health in resourcelimited settings.
Our department raises following three activities
as international contribution; advocacy oninternational health at national and international level,
health promotion activities and empowerment at thecommunity/ grassroots' level and emergency relief.
What our department thinks of important inthose activities is to make solidarity in order toimprove people's health and contribute to people's
sustainable development. It is our department's
goal.

― 18 ―

Professor
Assistant Professor
Assistant Professor
Assistant Professor
Research Fellow
Visiting Professor
Visiting Professor
Visiting Professor
Visiting Professor
Visiting Researcher
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Taro Yamamoto
Takayuki Wada
Tomoo Ichikawa
Masayuki Nakano
Hiromu Ito
Shigeru Suganami
Kui-Chen Zheng
Ishii Masami
Akihiro Seita
Taijin Kaku
Liang Qin
Guoxi Cai
Mohamed Elsayed
Kayo Maeda
Shuko Takahashi
Yoshihiro Takayama
Shiomi Yoshida
Kaori Yamamoto
Raoping Tu
EZZAN SAEED MOHAMMED KUNNASWETA KOIRALA

species composition of vectors and their behavior,and monitoring their insecticide resistance in East
Africa.

Department of Vector
Ecology & Environment
Our research interests include anything from
ecology to molecular biology of medically important
arthropods, particularly mosquitoes that transmit
diseases such as malaria and dengue. We are alsointerested in their relationships with environmental
variables and development of environmentallyfriendly vector control tools.
1. Dengue vectors
As dengue vectors are extending theirgeographic distribution, the spread of the disease isbeing concerned. It has been suspected that the
expansion of vector distribution is due toenvironmental factors such as climate change. We
are currently mapping their geographicaldistributions in South East Asia and Africa, andexamining the relationships with environmental
factors.
2. Malaria vectors
We are examining ecological and physiologicaldifferences among the members within the
Anopheles gambiae complex group and theAnopheles funestus group in Kenya and Malawi. We
are also investigating their geographic distributions,and monitoring their abundance in East Africa. Thisextensive field survey was designed to understandthe effects of climate and develop a climate basemalaria prediction model.
3. Vector control measures
The coverage of insecticide treated bed nets
(ITNs) has considerably increased in Africa. We areinvestigating whether local residents properly use
and maintain ITNs, and how long ITNs last. We arealso investigating the effects of bed nets on the― 19 ―

Professor
Associate Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant Professor
Assistant
Assistant
Assistant
Assistant
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student

Noboru Minakawa
Hitoshi Kawada
Toshihiko Sunahara
Yukiko Higa
Takashi Tsunoda
Kyoko Futami
Ataru Tsuzuki
Chaves Sanabria Luis Fernando
Hu Jinping
Chiaki Tsurukawa
Naomi Sano
Ikumi Fritz
Junko Sakemoto
Koji Yamada
Yusuke Sumita
Huynh Thi Thuy Trang
Nozomi Imanishi
Owuor Gabriel Owino
Sai Zaw Min OoDepartment ofClinical Medicine

Lazaro Hospital to make further progress in research of
infectious diseases. We also coordinate a bed-side clinicaltraining course on tropical infectious.

This is the only clinical department in NEKKEN, which
has clinical activities in Nagasaki University Hospital. We
conduct a wide range of multi-disciplinary studies linking ourstrength of clinical epidemiology to laboratory-based
microbiology and immunology studies both in- and outside
Japan. Our main research interests are respiratory infectious
diseases, tuberculosis (TB), HIV/AIDS and tropical infectious
diseases. Specific research activities are described as follows:

4. HIV Cohort Studies in Northern Thailand
In collaboration with National Institute of Health, Thailand,
we conducted a cohort study targeting HIV-infectedindividuals and their spouses in Lampang Hospital, northern
Thailand between July 2000 and December 2010; nearly
2000 people participated. The main objectives of this cohort
are to understand mechanisms of resistance to HIV infection
among HIV-exposed but uninfected spouses living with HIVinfected patients and mechanisms of slow-progression
among HIV-infected slowprogressors. Data and sample
analysis are still continuing as collaboration between Thaicounter parts and international experts in hostgene
polymorphisms, molecular immunology, molecularepidemiology and virology.

1. Respiratory Infections Diseases
We have developed multiplex-PCR assays to identify 19
different viral and bacterial respiratory pathogens and also
developed a novel nano-fluidic real time PCR-based assay todetermine 50 pneumococcus serotypes. These molecular
assays are now being applied for several clinical studies
including a multi-center epidemiological study for adultpneumonia in all over Japan and childhood acute respiratory
infection study in central Vietnam. We published a paper
describing epidemiology of adult pneumonia in 2015 and arepreparing several other papers investigating viral infection,
pneumonia in elderly, and serotype distribution and drug
resistance of pneumococcus. In 2009, we commenced abirth cohort studies, recruiting approximately 2,000 pairs ofmothers and new-born babies, which facilitates studies ofhost-gene polymorphisms associating the severity of pediatricinfectious diseases. For the development of a novel treatment
strategy, we also investigate the pathogenesis of treatmentrefractory pneumonia at molecular levels focusing on
macrophage function, of clearing apoptotic cells from theinflammation site.

Professor
Associate Professor
Assistant Professor
Assistant Professor
Associate professor
Visiting Researcher
Visiting Researcher
Visiting Researcher
Assistant
Assistant
Assistant
Assistant
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student
Graduate student

2. Tuberculosis
For better-diagnosis of latent MTB infection andtuberculosis, we are analyzing cellular immune responses tovarious TB antigens using an intra-cellular cytokine staining
assay to evaluate a range of cytokines profile in various
stages of TB infection and their contact cases both in Japan.
Our goal is to clarify TB-specific cellular immune responses
characteristic to a different clinical stage of TB infection. We
also investigated pathogens causing bacterial pneumonia andits impact on the survival prognosis of TB patients admitted to
the National Infectious Diseases Hospital (San Lazaro
Hospital) in the Philippines.
3. Clinical Research in Infectious Disease Hospitals in the tropics
In collaboration with National Institute of Infectious
Diseases, Tokyo, we are conducting undiagnosed febrileillness study in the Department of Infectious Diseases, Bac
Mai Hospital, Hanoi, Vietnam by applying diagnostic tests for
leptospirosis and various richettial diseases. In collaboration
with the San Lazaro Hospital, the Philippines, we areconducting leptospirosis study to evaluate the new diagnostic
test and to improve clinical management. We haveestablished a new laboratory of microbiology in the San

Koya Ariyoshi
Konosuke Morimoto
Motoi Suzuki
Hikaru Sato
Yoshiro Yamashita
Michio Yasunami
Masahiko Mori
Taisuke Nakaura
Rina Shiramizu
Kyoko Uchibori
Hitomi Nakamura
Yumi Hamasaki
Tohru Ogasawara
Reiko Miyahara
Nobuo Saito
Ikumi Sawada
Satoshi Kakiuchi
Tomoko Ishifuji
Ngo Chi Cuong
Emi Kitashoji
Hiroshi Fujii
Shungo Kato
Hiroyuki Ito
Kenichi Nobusue
Hirotomo Yamanashi
Kentaro Hayashi
Eiichiro Sando
Tomako Hiraoka

Bed-side clinical training course in San Lazaro Hospital― 20 ―

Department of Pediatric
Infectious Diseases
The Department of Pediatric Infectious Diseases
is a recently expanded department under the ClinicalResearch Division at Institute of Tropical Medicine.
We work on a wide range of infectious diseases withspecial attention on severe pediatric infectious
diseases including pneumonia, diarrhea, dengue andmalaria. Our research interests include integration ofclinical, environmental and social issues at global,
national and local levels.
Cohort studies on Pediatric Infectious Diseases in Vietnam
We receive funding from the Japan Initiative for
Global Research Network on Infectious Diseases(JGRID), Japan Agency for Medical Research andDevelopment (AMED) to conduct a large population
based cohort study on Pediatric Infectious Diseases
in Nha Trang, central Vietnam since 2006. We arefocusing on severe common pediatric infectious
diseases (SPID) such as acute respiratory infection(ARI), diarrhea and dengue which are the major
causes of under 5 mortality.
Pediatric ARI surveillance: A population based
hospitalized Pediatric ARI surveillance at Khanh Hoa
General Hospital, Nha-Trang, Vietnam wasestablished to determine incidence, etiology and risk
factors for pediatric ARI/pneumonia since 2007. We
also investigate the emergence of new viruses andits molecular and clinical importance.
Birth cohort study: We are also conducting abirth cohort study on 2000 new born babies in Nha
Trang, Vietnam since 2009. This study was
conducted to study congenital infection and hostgenetic
factorsonphysical-neurologicaldevelopment of the child and development of SPID.
We are also studying congenital rubella infection andits complication in Vietnam.
Pneumococcal conjugate vaccine (PCV)
reduced dosing trial: We received a multimillion
dollar grant from Bill and Melinda Gates Foundation
to conduct a PCV reduce dosing trial in Vietnam. We
believe that the study outcome will change global
PCV vaccination strategy to improve the availabilityof PCV and other vaccines in developing countries.
Health impacts of global environmental change
Our research interests extend over a range ofissues in environmental epidemiology. The current
research topics, which we work in collaboration withboth the international and Japanese colleagues,
focus on the health impacts of atmosphericenvironmental changes including global climatechange and transboundary and local air pollution.
Ongoing projects include:
1. Effects of flooding and weather on diarrhoea,
acute respiratory infections and other infectious
diseases.
2. Ocean-atmosphere interaction phenomena
including the Indian Ocean Dipole and its
association with malaria and cholera in the
Eastern and Southern Africa.
3. Health effects of local and transboundary air
pollution in Japan and in the East and Southeast
Asia.
4. Mortality risk of temperature extremes in tropicalclimate where we estimate excess mortality
associated with exposure to temperature
extremes and the extended period of heat intropical countries.
5. Respiratory health effects of the different chemicalcomposition of airborne particulate matter andthe sources.
6. Heat effect on mortality in Japan
7. Associations between weather factors and suicide
in multiple countries in Asia, Europe, and America
Professor
Masahiro Hashizume
Professor
Lay Myint Yoshida
Assistant Professor
Chris Fook Sheng Ng
Assistant Professor
Yoonhee Kim
Assistant Professor
Michiko Toizumi
Assistant Professor
Noriko Kitamura
Assistant Professor
Mizuki Takegata
Assistant Professor
Chihiro Iwasaki
Visiting Researcher (JSPS) Minh Nhat Le
AssistantNozomi Oka
Assistant
Setsuko Hirakura
AssistantKaori Yoshida
Graduate student
Keisuke Yoshihara
Graduate student
Eriko Ikeda
Graduate student
Naohiko Matsusita
Graduate student
Saki Tanaka
Graduate student
Atsushi Fujioka

Environmental change and global
health research in Bangladesh
Pediatric infectious diseases
research in Vietnam― 21 ―

Department of Clinical
Product Development
This is a newly established department inresponse to the Global Strategy on public health,innovation and intellectual property (resolution
WHA61.21). The resolution calls for the enhancementof health-needs driven research and development toaddress diseases that disproportionately affectdeveloping countries. The establishment of thisdepartment was supported by the Department of
Academic and Research Promotion, Ministry of
Education, Culture, Sports, Science and Technology(MEXT), Japan. MEXT continues to support the
department until its full development.
The department focuses on:
1. building capacity of individuals for innovation in
health product2. strengthening capability of the local research
institutions in providing an enabling environment,
including infrastructure for product R&D
3. strengthening research institutes network forknowledge sharing and exchange, and for R&D
technology transfer activities. The emphasis will
be on developing products for public healthneeds to address the issues of inequity in health.
4. Development of health products

2. Research1) Development of Shiunko for Cutaneous
Leishmaniasis;2) Identification and further development of Herbal
Medicine for Breast cancer, Cholangiocarcinoma
and Malaria.
3) Development of Methodology for Enhance
Informed Consent for clinical trials.
3. Network
1) Coordination of Product Research andDevelopment (PRD) Network
2) Coordination of research ethics global network:
Strategic Initiative for Developing Capacity in
Ethical Review (SIDCER)
Collaborations:
1. Drug Research Center, Thammasat University,
Bangkok, Thailand
2. Forum for Ethical Review Committees in the
Asian and Western Pacific Region (FERCAP),
Bangkok, Thailand
3. Armauer Hansen Research Institute, Ministry of
Health, Addis Ababa, Ethiopia
4. Institution of Human Research Protection,
Ministry of Health, Thailand
5. Tokyo University, Tokyo, Japan
6. Government Pharmaceutical Organization,
Bangkok, Thailand

The operation of this department depends onthe collaboration of existing offices and departments
in NEKKEN and in Nagasaki University, e.g. Office
for Training and Education, Immunogenetics,
Toxicology, Clinical Pharmacy, Parasitology, Clinical
Medicine, Clinical Paediatrics, Center for infectious
disease research in Asia and Africa and the research
institutions and universities in developing countries.
The aim of its operation is to ensure that research
priorities of research institutions are in line with their
public-health needs, in particular the need forinnovative research to address the health problemsof their populations and to contribute to improved
public health in other countries.
The activities:
1. Training
1) Two- week course on Product Research andDevelopment for public health needs;
2) Three-day course on Bioethics
3) PhD training as part of actual product development
ie. Shiunko for Cutaneous Leishmaniasis, Herbal
Medicine for Cholangiocarcinoma and Malaria4) PhD training as part of associated productdevelopment processes e.g. ethical issues in
product development, clinical data management,
good laboratory practice and etc.
― 22 ―

Professor
Associate Professor
Assistant Professor
Visiting Professor
Visiting Researcher
Assistant
Graduate Student
Graduate Student

Juntra Laothavorn
Nguyen Huy Tien
Syusaku Mizukami
Kesara Na-Bangchang
Tullayakorn Plengsuriyakarn
Sayuri Delaney
Nut Koonrungsesomboon
Martha Lemma

Center for Infectious Disease
Research in Asia and Africa○Kenya Research Station

OutlineNagasaki University Kenya Research Station isan overseas research station that was establishedthrough the “Program to Establish Infectious Disease
Research Network” (Sept. 2005- Mar. 2010)
and“Tropical Medicine, Emerging Infectious Disease
and Clinical Epidemiological Research Program”(Apr. 2010-Mar. 2016) funded by the Ministry of
Education (MEXT) in Japan. Since April 2016, thesite received renewed funding from MEXT titled,“Program for Research and Capacity Development
Toward Infectious Diseases Control” to establish an
education and research collaboration platform for
Kenya and Japan”.
The goals of this project are to strengthen the
Kenya Research station, to train young researchers
on emerging and re-emerging infectious diseases,
and to collaborate with local researchers on longterm projects.
Progress
1. Establishment of The Research Station
We have made progress on establishing the
Kenya Research Station in Nairobi (including the
Biosafety Level 3 laboratory) and field researchsites in Mbita, Kwale and Busia. Renovation of thebuilding and conference rooms, maintenance of
information systems, and procurement of vehicles
are currently ongoing.
2. Researchers and administrative staff from JapanFive
researchers
includingthe
Chief
Representative and three administrative staff
members were dispatched from Japan to Kenya. An
Assistant Professor and a Researcher are working
as JICA Experts for the STAREPS project. Four
Professors and three Assistant Professors havesupported our project through short-term visits.
3. Contribution to the Community members
In Mbita and Kwale areas, Health and
Demographic Surveillance System (HDSS) has
collected data on population, birth and death
rates, and incidences of diseases over time.
Mosquito Surveillance System (MSS) collects andanalyzes data on malaria mosquitos in Mbita. In
2012, we began a new project through the JICA
Partnership Program focusing on school health in
Mbita which has been ongoing since 2009.
4. Tropical Medicine Research
Research on parasitology, malaria eradication,and mosquito transmission research are ongoing in

Our members

Western Kenya, Research on bacterial and viraldiarrheal disease and mosquito-borne hemorrhagic
fever are continuing in the laboratories at the P3
lab in Nairobi Office and at the Kenya Medical
Research Institute, Production Department.
In Kwale, epidemiological research of maternal
child health are being conducted. As the “TheProject for Development of Rapid Diagnostics andthe Establishment of an Alert System for Outbreaksof Yellow Fever and Rift Valley Fever in Kenya” of
JICA-AMED SATREPS Project launched in March
2012, we completed setting up two KEMRI labs at
the KEMRI Production Department and in Busia.
The mSOS system (mobile SMS-based disease
outbreak alert system) was established at the
Ministry of Health.. A lab. for seroepidemiology
project focusing on NTDs (neglected tropicaldiseases) was set up with funding by the Japan
Science and Technology Agency (JST) (1st phase:
2009-2011, 2nd phase:2011-2016). The 3rd phasestarted in Nov. 2015.
5. Educational Programs
Five medical doctors from Kenya graduated from“the Master of Tropical Medicine at the Institute ofTropical Medicine in Nagasaki”. Two Kenyan
students are currently enrolled in graduate school of
the “Program for Nurturing Global Leaders in
Tropical and Emerging Communicable Diseases” at
the Institute of Tropical Medicine. Every year, we giveopportunities for three master students from “TheNagasaki University School of Tropical Medicine andGlobal Health” to study in Kenya. We also haveaccepted medical school students from Osaka
University, Osaka City University and Shiga Universityof Medical Science and so on for field trainings.
Project Members
Leader and Professor Yoshio Ichinose (Kenya)
Noboru Minakawa
Professor
Shinjiro Hamano
Professor
Masahiro Hashizume
Professor
Satoshi Kaneko
Professor
Shingo Inoue (JICA Expert/ Kenya)
Assistant Professor
Kyoko Futami
Assistant Professor
Yoshito Fujii
Assistant Professor
Mohammad Shah
Assistant Professor
Rie Takeuchi(Kenya)
Assistant ProfessorPeter Larson(Kenya)
Assistant Professor
Mitsuru Toda (JICA Expert/ Kenya)
Research Fellow
Haruki Kazama (Kenya)
Administrator
Administrative/HR Manager Yukie Saito (Kenya)
Masayuki Kotani (Kenya)
Chief Accountant
Kaori Kaneko
Administrator
Shunpei Kambe
Graduate Student
Gabriel Dida
Graduate Student
Ernest Apondi
Graduate Student

NUITM Kenya Research Station
Mbita Research Site
(Nairobi Office)― 23 ―

Kwale Research Site

Center for Infectious Disease
Research in Asia and Africa○Vietnam Research Station

OutlineThe Institute of Tropical Medicine of Nagasaki
University (ITM) and the National Institute of Hygieneand Epidemiology, Vietnam (NIHE), have been jointly
conducting a collaborative project since 2005 on
emerging and reemerging infectious diseases undera grant from the Ministry of Education, Science,
Culture and Technology (MEXT) of Japan. A Vietnam
research station established on the NIHE campus
has been the site of a number of research activities.
The project for clarifying environmental and social
factors affecting outbreaks of zoonosis, vector-borne
infectious diseases, diarrhoea, and childhood
pneumonia has been conducted within acollaborative project framework. Having achieved
the goals set or research in the project's first phase(from 2005 to 2009), the next objectives had been
underlined, clarifying the factors and mechanisms
causing infectious diseases (from 2010 to 2014).
Since 2015, the project has been taken over tothe third phase under a grant from the newly
established Japan Agency for Medical Research andDevelopment (AMED). Four main subjects i.e.,
Dengue fever, Infectious diarrhoea, Influenza, andDrug resistant bacteria were selected for taking theaim of development an intervention-based method
to inhibit the spread of infectious diseases. In
Vietnam Research Station, we proceed over 20
independent activities including collaborative
research with other Japanese institutes. To conduct
projects on a higher level, cooperation has been
established with three Vietnamese governmental
research institutions and with JICA-supported
national hospitals. The outcome of such activities are
expected to contribute greatly to promoting publichealth and improving medical care.
Research activities (The activities implemented in the
J-GRID program were described)
The objectives of the entire project are (1) toclarify the ecology of pathogens in nature and in
human society, (2) to clarify the pathogenic
mechanism of human diseases. The principal
research agenda are as follows:
1. Dengue fever research:
1) Comprehensive analysis of dengue viruses for
identification of pathological factors andapplication in new drug development.
2) A study of mosquito vectors, pathogenic
mechanism of dengue fever, and anti-infection
measures3) Control of dengue-transmitting mosquitoes byinsect growth regulator
4) Searching for the potential seeds for prevention
2. Dengue fever research (consortium):
1) Inter-regional analysis of dengue viruses
2) Global movement and variation of dengue
vector mosquito: Building a database forcountermeasure
3. Infectious diarrhoea research:
1) A study on the effects rotavirus vaccine will
make on the reduction of diarrhoeal disease
burden and the dynamics of circulating strains
2) Hospital based and a community based studies
of a broad range of etiological agents ofdiarrhoea in Vietnam
3) A molecular epidemiological study of Vibrio
cholerae in ecosystem in Vietnam
4. Infectious diarrhoea research (consortium):
1) Inter-regional studies of a broad range of
etiological agents of diarrhoea in Southeast
Asia
5. Pediatric acute respiratory infection research:
1) A birth cohort based study for acute respiratory
infection2) A birth cohort based study for influenza
3) A birth cohort based study for drug resistantPneumococcus
Vietnam Research Station (VRS) staff
Professor (Project)
Futoshi Hasebe
Assistant Professor
Takashi Tsunoda
Assistant Professor
Taichiro Takemura
Assistant Professor
Hanako Iwashita
Administrative Staff
Kei Saito
Research Assistant
Phan Hoai Linh Ly
Research AssistantTran Thi Luong
Research Assistant
Doan Thi Hang
Research Assistant
Le Thi Kim Anh
Research AssistantNguyen Thi Hang
Research AssistantPham Hong Quynh Anh
Research AssistantNguyen Thu Trang
Research AssistantPham Ha Chau
Research AssistantNguyen Thi Dung
Research Assistant
Vi Thi Quynh Trang
Secretary
Bui Thu Tra
Assistant
Mayumi Ogawa― 24 ―

Tropical Medicine Museum
Museum of Tropical Medicine was preceded by
the Tropical Medicine Reference Centre, which wasestablished in 1974 and was reorganized in 1997 as
Tropical Medicine Reference and Information Center.
In 2001, it was renamed as Research Center
Tropical Infectious Diseases (RECTID) and in 2008 it
was established as an auxiliary institution. In
addition, the present museum was moved toNagasaki University Museum of Medicine. The
display was renewed.
The institution performs the following 2functions.
The institute primarily functions as a museum
and resource center for tropical disease. There is a
general section providing information on tropicaldiseases, parasites bacteria viruses poisonous
insects and specimen of dangerous animals,
valuable books, and displays images of the data.
Moreover, it has an audio-visual roomaccommodating a few numbers of people.
Furthermore, a system is being developed for using
this collection of resources to strengthen publicscience and risk communication with thousand
points relating to the history and philosophy oftropical medicines and infection symptoms. From
April, 2015 through May, Nagasaki University held
“the Nagasaki University exhibition which fought
against an infectious disease” in Nagasaki Museum
History and Culture. We provided much exhibits
about the tropical disease, and citizen’s people saw
it.
It also functions as an information center for the
dispatch, collection, organization, and analysis of
information on tropical medicine. This has become
an essential component of the daily research

activities related to tropical medicine. Due toinfrastructure rearrangement in 2012, network tools
were updated with technological innovation and long
lasting safety; thus responding to every need of theusers. We also serviced various databases, using a
research evaluation system and a database of thetropical medicine museum. Moreover, we provide asimilar environment to research universities overseas
with VPN by including video conferencing system topromote international conferences and e-learningplans.
Head and Professor
Professor
Coordinater
Technologist
Assistant
Assistant

Noboru Minakawa
Masahiro Horio
Shohei Hashiguchi
Kazuo Araki
Kiyomi Suda
Sayaka Taniyama

The database server

Tropical Medicine Museum

Tropical Medicine Museum― 25 ―

Central Laboratory
The aim of Central Laboratory is to operate andefficiently manage common equipments and tosupport general laboratory activities in the institute.
In addition, this laboratory also supports research
activities conducted in the instutite by extramuralinvestigators.

○Molecular & Cellular Biology Unit

Molecular & Cellular Biology Unit is responsible
to maintain and operate following equipments
located in Central Laboraotory; 16- and 48-cappilary
sequencers, GS junior genome sequencer and mass
spectrometry-based genotyping system for genome
analysis; flowcytometer for cell function analysis;
fluorescence-luminescenceimager for visualization
analysis; and Luminex bead-array system andfluorescence-luminescence multilabel counter for
multipurpose analysis. In addition, this unit is also
responsible to maitain equipments/facilities tosupport general laboratory activities; such as purewater supply, ultracentrifuge, lyophilizer, Speed-Vac,
French press, Bioruptor, sample storage in liquid
nitrogen, bio-safety cabinet, autoclave, dark roomand cold room.

Researchers using 16-capillary sequencer○Light Microscope Unit

Light Microscope Unit provides optical
instruments to perform basic, translational, andclinical research on the imaging features of infectious
disease. We operate Nikon Infectious Disease
Imaging Corelaboratory established in April 2015.
The laboratory has equipped laser scanningconfocal/fluorescence microscope (NIKON), Imaging
flowcytometer (MERCK), and laser scanningconfocal/superresolution microscope (ZEISS).

pathogens and the structural change of thepathogen-infected cells. This unit offers high quality
imaging services by state-of-art techniques such as
conventional and immuno-electron microscopy and
3D tomography, and also provide training on sample
preparation and equipment usage. This unit is
responsible for transmission and scanning electron
microscopes (JEOL), high-pressure freezer (LEICA),
ultra-microtomes (LEICA and REICHERT), vacuum
coater, critical point dryer system, and osmium
plasma coater in addition to general laboratory
facilities for a wide range application of electron
microscopy.

Transmission electron microscope○Eco-health Unit

In order to promote people s health in the world,
it is essential to understand the health in the context
of social and ecological interactions (Eco-system).
By such multi-disciplinary approach this unit
explicates factors associated to ill-health, especially
infectious diseases which are preventable byappropriate counter measures. Main focuses are: 1)
Emerging antimicrobial resistant bacterium in aquatic
environment, 2) Problems related to tuberculosis
medication under conditions of conflict and largescale disaster, 3) Rapid changes in Eco-system andmorbidity pattern among ethnic minorities.
In October 2013, Eco-health Unit initiatedcohort studies (children under 5 years of age) toinvestigate risk factors influence on child health in
Savvannakhet province in Lao PDR. Since then thecohort has been followed up every 2 weeks. This
study will be continued until March 2018.

Field survey in Lao PDR

Practical exercise in the PhD programusing Super Resolution Microscope○Electron Microscope Unit
Electronultrastructural

Microscope
Unitsuppportscharacterization of microbial― 26 ―

Head and Professor
Associate Professor
Senior Assistant Professor
Assistant Professor
Assistant

Osamu Kaneko
Junko Okumura
Mihoko Kikuchi
Miako Sakaguchi
Masae Masumoto

NEKKEN Bio-Resource Center（NBRC）The Government of Japan has been making
efforts under its second and third Science andTechnology Basic Plans to create a world-class
intellectual platform. In FY2002 the Ministry of
Education, Culture, Sports, Science and Technology(MEXT) implemented the National Bio-Resource
Project (NBRP) to construct the framework forsystematic collection, preservation, and distributionof bio-resources with a focus on those that required
strategic development by the National Government.
To promote life sciences it is important that
researchers share the various bio-resources
necessary for pursuing research and development.
The resources produced in years with painstaking
labor will make foundation for future researches. The
NBRP deals with the bio-resources, which will not
be able to be restored again if once they are lost.
Through the revision every five years, the NBRP has
reached the final year of the 3rd phase in FY2016,
and the NBRP has been operated under the controlof Japan Agency for Medical Research andDevelopment (AMED) since FY2015, and the 4thphase of the NBRP will start in FY2017.
Since 2002 Institute of Tropical Medicine(NEKKEN), Nagasaki University has been taking of
Division of Protozoa in Pathogenic Microorganismsof a Core Facility Upgrading Program under Medical
Mycology Research Center, Chiba University.
NEKKEN Bio-Resource Center (NBRC) contributes
the services to researchers, (1) information ofowners and strains of pathogenic protozoans inJapan on database Website, (2) supply of
protozoans from NBRC, (3) acceptance of
protozoan deposit to NBRC and the preservation, (4)supply of protozoan specimens for laboratory
practice of medical-educational schools, (5)examination for protozoan infections from any
medical facilities. (6) instructions for protozoan
detection and for the culture. Pathogenic protozoan
resources, which can be supplied by NBRC, arelisted in the figure.
We would like to ask the access to our ProjectWebsite. Your cooperation and support for the
project would be highly appreciated.
http://www.tm.nagasaki-u.ac.jp/nbrc/
E-mail:protozoa@tm.nagasaki-u.ac.jp
Project Representative
Service Representative
Advice Collaborator
Advice Collaborator
Advice Collaborator
Counselor
Technical Collaborator
Information Desk

Kouichi Morita
Kenji Hirayama
Osamu Kaneko
Shinjiro Hamano
Richard Culleton
Kiyoshi Kita
Tetsuo Yanagi
Yumeko Yoshitsugu

Parasitic Protozoa
Alveolata
Apicomplexa

Plasmodium falciparum
Plasmodium berghei
Plasmodium chabaudi
Plasmodium yoelii
Plasmodium vickei
Cryptosporidium sp.
Toxoplasma gondii
Stramenopiles

Blastocystis hominis
Excavata
Euglenozoa

Leishmania spp.
Trypanosoma brucei gambiense
Trypanosoma brucei rhodesiense
Trypanosoma brucei brucei
Trypanosoma congolense
Trypanosoma evansi
Trypanosoma cruzi
Trypanosoma rangeli
Trichozoa

Giardia lamblia
Chilomastix mesnili
Trichomonas spp.
Heterolobosea

Naegleria fowleri
Amoebozoa

Entamoeba histolytica
Entamoeba nuttalli― 27 ―

LF-NTD Unit
Global efforts to control, eliminate or eradicate
neglected tropical diseases (NTD) are fast
progressing in recent years. Lymphatic filariasis (LF)
is not an exception. Under Global Programme to
Eliminate Lymphatic Filariasis (GPELF), endemic
countries are progressively scaling up interventions
with partnership at national and global levels
towards the common goal to eliminate the disease
as a public health problem by 2020.
The purposes of this unit are to establish andkeep the data warehouse of the programme and tofoster professionals not only with knowledge but
also with global vision who can contribute to theglobal partnership to fight against LF and NTDs.
Activities:
1) Data collection and management
1. Collection and management of data andinformation related to LF/NTDs from the world
2. Participation in and contribution to the expert
meetings related to LF/NTDs at national andglobal level4) Trainings on tropical disease control
1. Lectures and trainings for students andprofessionals
2. Publication of documents, development oftraining materials and curriculum

5)2) The bridge between Japan and the world in thearea of tropical control
1. Establishment and maintenance of global
network
2. Promotion Japan's participation in the global
partnership

3) Advocacy and information dissemination in Japan
1. Lectures, meetings, media on tropical disease
control
2. Information sharing and exhibition to thegeneral public― 28 ―

PacELF Endgame Project
1. A joint project with James Cook University
2. Data catalogue, Case studies, PacELF Way II
book

Director
AssistantKazuyo Ichimori
Yukiko Baba

Professor

Shinjiro Hamano

The University Hospital
Infectious Disease Ward
The department of clinical medicine, theInstitute of Tropical Medicine has a clinic and runs
the infectious disease ward in the Nagasaki
University Hospital. It has 16 beds for generalpatients and 8 negative pressure rooms, toaccommodate patients with TB and other special
pathogens. We specialized in infectious diseases
and respiratory diseases; these include systemic
infectious diseases, including tropical infectious
diseases, HIV/AIDS, tuberculosis, pneumonia, andvarious neoplasmic and inflammatory respiratory
diseases. We see well approximately 500
consultation cases a year in other wards, for giving
advices on diagnosis and treatment of infectious
diseases. Outpatient clinic is open twice a weekwhere we also run a travel clinic for international
travelers.
For training and education, we provide anumber of lectures on infectious diseases andrespiratory diseases to both under graduate andpost graduate students and bed-side training
programs for resident physicians. We organize aclinical case conference of tropical infectious
diseases as a part of Master of Tropical Medicine
course, Graduate School of Biomedical Sciences.
Staff doctors and resident doctors are regularly
dispatched to hospitals in abroad, such as, San
Lazao Hospital, the Philippines and the infectious
disease ward in Bac Mai Hospital, Vietnam.

Professor
Associate Professor
Senior Lecturer
Assistant Professor
Assistant Professor
Assistant Professor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Fellow Doctor
Senior Resident
Senior Resident
Senior Resident
Senior Resident
AssistantStaff Members― 29 ―

Koya Ariyoshi
Konosuke MorimotoTakeshi Tanaka
Yoshiro Yamashita
Masahiro Takaki
Kensuke Takahashi
Izumida Mai
Reiko Miyahara
Rena Osawa
Emi Kitashoji
Satoshi Kakiuchi
Masahiro Sano
Shingo Masuda
Nobuaki Tsuyama
Kanako Shimamori
Eriko Ikeda
Ayako Matsuo

Number of Staff（as of May 1, 2016）

Divisions

Professor

Associate
Professor

Lecturer

Enrollment

12
(3)

5
(2)

3

※（

Assistant Research
Professor Associate
19(22)

Sub total

Others

Total

39
(27)

8
(11)

47
(38)

0

）number of fixed-term staff

Accounting（Fiscal Year 2015）

Revenue

Expenditure
AmountDivisions

AmountDivisions(in thousands of yen)(in thousands of yen)

Administrative cost subsidy

766,767

Administrative cost subsidy

766,767

Non-subsidy income at Nagasaki University

171,158

Non-subsidy income at Nagasaki University

171,158

Joint Research

32,100

Joint Research

47,926External Commissioned Research
Fund
Commissioned Project

1,091,405

675,22133,579External Commissioned Research
Fund
Commissioned Project

Endowment

38,112Endowment

21,924

Others

24,550Total

32,807

Others

24,5502,157,671

Total

1,740,353

Grant-in-Aid for Scientific Research from the Ministry of （FY 2015）
Education, Culture, Sports, Science and Technology
Scientific
Research
Scientific
Scientific
Scientific Challenging
Young
Type of
Scientific
Exploratory
Research on Fellowship for
Research Research(A) Research(B) Research(B) Research(C) Research Scientists(B) Innovative Areas Young Scientists

Total

Numberof Grants

3

13

2

9

4

8

1

1

41

Amount(in thousands)

29,12059,0207,020

14,1707,150

12,22018,4601,200

148,360

Facilities & Administrative costs included

Grant-in-Aid for Scientific Research from （FY 2015）
the Ministry of Health, Labour and Welfare
Type of
Research

Global Health
Issues

HIV/AIDS

Emerging andRe-emerging
Infectious Diseases

Total

Number of
Grants2

0

1

3

Amount(in thousands)

300

0

400

700

― 30 ―

Subsidy （FY 2015）

Type of
Research

National
Bio-resource
Project (NBRP)

Strategic Young
Researcher
Overseas Visits
Program for
Accelerating
Brain Circulation

Amount(in thousands)

4,100

20,450

Facilities & Administrative costs included

External Fund （FY 2015）
Divisions

Joint Research with
Private Sectors

Commissioned
Research

Commissioned
Project

Endowments

Number of Sources

8

30

9

43

Amount (in thousands)

32,1001,091,405

33,57938,112

Facilities & Administrative costs included

Agreement of Educational, Scientificand Scholarly Exchange◯Overseas

Name of organization of partner countries

Concluded date

Chiang Mai University (Thailand)
Mahidol University (Thailand)
National Institute of Hygiene and Epidemiology (Vietnam)
Airlangga University (Indonesia)
St. Luke's Medical Center (Philippines)
San Lazaro Hospital (Philippines)
Kenya Medical Research Institute (Kenya)
Thammasat University (Thailand)
National Institute for Communicable Diseases of the National Health
Laboratory Service (South Africa)
China Medical University (China)
Jiangsu Institute of Parasitic Diseases (China)
National Institute of Malariology, Parasitology and Entomology (Vietnam)
University of the Philippines Manila (Philippines)
Patan Academy of Health Sciences (Republic of Nepal)

February, 1988
November, 1999
June, 2001
January, 2004
February, 2004
August, 2004
November, 2004
March, 2006
July, 2010
September, 2010
September, 2010
November, 2013
January, 2014
July, 2014

◯Domestic
Name of organization of partner

Concluded date

The Research Institute of Tuberculosis Japan Anti-Tuberculosis Association― 31 ―March, 2009

Telephone Number
Institute of Tropical Medicine, Nagasaki University ０９５（８１９）７８００
Extension
Dean ……………………………………………………………… ７８０１
Head of Administrative Office …………………………………… ７８０２
Section Leader ………………………………………………… ４７１４Expert Staff ……………………………………………………… ７８１３
Chief of General Affairs Unit …………………………………… ４７０２
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Dean Secretary ………………………………………………… ７８５８
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Department of Virology
Professor ………………………………………………… ７８２７Associate Professor …………………………………… ８５８８
Information ……………………………………………… ７８２９
Facsimile ………………………………………………… ７８３０
Department of Emerging Infectious Diseases
Professor ………………………………………………… ７８４８
Staff room ………………………………………………… ７８４９
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Department of Bacteriology
Professor ………………………………………………… ７８３１
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Department of Protozoology
Professor ………………………………………………… ７８３５
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Lab.1 ……………………………………………………… ７８３７
Information ……………………………………………… ７８３８
Senior Assistant Professor ……………………………… ７８１５
Department of Parasitology
Professor ………………………………………………… ７８２２
Staff room ………………………………………………… ７８２３
Facsimile ………………………………………………… ７８２４
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Department of Immunogenetics
Professor ………………………………………………… ７８１８Senior Assistant Professor ……………………………… ７８４５
Information ……………………………………………… ７８２０
Facsimile ………………………………………………… ７８２１
Department of Pathology
Associate Professor …………………………………… ７９０３
Assistant Professor ……………………………………… ７８１４

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Department of Eco-epidemiology
Professor ………………………………………………… ７８６６
Assistant Professor ……………………………………… ７８６７Lab.1 ……………………………………………………… ７８５４
Information ……………………………………………… ７８６６
Department of International HealthProfessor ………………………………………………… ７８６９
Lab.1 ……………………………………………………… ７８０８
Lab.2 ……………………………………………………… ７８５３
Information ……………………………………………… ７８６９
Department of Vector Ecology and Environment
Professor ………………………………………………… ７８１０
Staff room ………………………………………………… ７８１１
Information ……………………………………………… ７８０９
Facsimile ………………………………………………… ７８１２
Department of Clinical Medicine
Professor ………………………………………………… ７８４０
Associate Professor …………………………………… ７８７３
Information ……………………………………………… ７８４１
Information ……………………………………………… ７８４２
Facsimile ………………………………………………… ７８４３
Department of pediatric Infectious Diseases
Professor ………………………………………………… ７７６３
Professor ………………………………………………… ７２８４
Information ……………………………………………… ７７６４
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Professor ………………………………………………… ７２８５
Information ……………………………………………… ７５５８
Center for Infectious Disease Research in Asia and Africa
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Kenya Research Station Assistant Professor ………… ７８３２
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Professor ………………………………………………… ７８１７
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Central Laboratory
Eco-health Unit ………………………………………… ７８５９Electron Microscope Room …………………………… ７８５９
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Location map of the Institute ofTropical Medicine on SakamotoCampus of Nagasaki University

PlaygroundGymnasium
Laboratory Animal Center
for Biomedical Research

Medicine Museum

Sub-Gate

Grobal Health General
Tropical Medicine Museum Research Building(In part of the 1st Floor)
Research Building of
the Institute ofTropical Medicine
Parking

Radioscope
Research Center

Main Building of
the Institute ofTropical Medicine
Medhcine(7,782㎡)
Atomic Bomb
DiseaseInstitute

School of Medicine

Main Gate
MedicalBranchLibrary
Commemoration
Hall

Pompe
Hall

Back Gate

Alumni HallN
for University Hospital
RyoJunHall― 34 ―

Location map of Institute of Tropical Medicine,
Nagasaki University in Nagasaki City▲
Mt.InasaN

Ropeway

Nagasaki Bay

Urakami

fo

rK

og

ak

ur

a

Hamaguchi-machi
Urakamieki-mae
NagasakiAkasako
Ohashi for

Igakubu-mae
School of
Dentistry

Ohato

Matsuyama-machi

Nagasakieki-mae

University
Hospital

School ofMedicine

Urakamitensyudo-mae

Ishibashi
Tsukimachi

Prefectural OfficeInstitute of Tropical
Medicine

City Hall

Chuobashi

Kokaido-mae
Suwajinja-mae

JR Kyushu
Electric Tramway

Shokakuji-shita

Main bus routefor Mogi

for Hotarujaya

How to get the Institute○From JR Nagasaki Station
Electric Tramway Nagasaki Station → (bound for Akasako) → Hamaguchi-machi → about 10-minute walkNagasaki Bus Nagasaki Station → (No.8 bound for Shimoohashi via School of Medicine) → School of Medicine○From JR Urakami Station
Electric Tramway Urakami Station → (bound for Akasako) → Hamaguchi-machi → about 10-minute walk
○From Nagasaki Airport
Kenei Bus Nagasaki Airport No.4 Bus Stop → (bound for Nagasaki City via Showa-machi and Urakami)→ Urakami Station → refer to from JR Urakami Station above
Location
1-12-4 Sakamoto Nagasaki 852-8523
URL http://www.tm.nagasaki-u.ac.jp
Published on July, 31 2016
Edited by Institute of Tropical Medicine, Nagasaki University
Printed by Quick Print