ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄ (ሶߤ߽ኅᐸ✚ว⎇ⓥ੐ᬺ㧕ಽᜂ⎇ⓥႎ๔ᦠ
ಽᜂ⺖㗴㧦‫ޟ‬⠌ᘠᵹ↥ߦኻߔࠆ఺∉≮ᴺߥࠄ߮ߦ᛫ಝ࿕≮ᴺ∝଀ߩ⥃ᐥ⊛ᬌ⸛‫ޠ‬ಽᜂ⎇ⓥ⠪ ↰ਛ ᔘᄦ㧔᧲੩ᘏᕺળක⑼ᄢቇ࡮↥ᇚੱ⑼࡮ᢎ᝼㧕⎇ⓥදജ⠪ Ꮉญ ㉿ᕺ㧘᪢ේ ᳗⢻㧘㜞ᯅ ⛗ℂ㧘࿯ᯅ 㤗⟤ሶ㧘㥲⮮ ᐘઍ㧘          ๺↰ ⺈ม㧔᧲੩ᘏᕺળක⑼ᄢቇ࡮↥ᇚੱ⑼࡮ഥᢎ㧕      ᧖ᶆ ஜᄥ㇢㧘ᄢᶆ ⸠┨㧔᧲੩ᘏᕺળක⑼ᄢቇ࡮↥ᇚੱ⑼࡮⻠Ꮷ㧕⎇ⓥⷐᣦ
 ෻ᓳ޽ࠆ޿ߪ⠌ᘠᵹ↥ߩේ࿃ߣߒߡ㧘ේ⊒ᕈ޽ࠆ޿ߪ⛯⊒ᕈᵹ↥ߦ߆߆ࠊࠄߕ㧘᛫࡝ࡦ⢽⾰᛫૕㧔aPL㧕㓁ᕈߩ㗫ᐲ߇ 70%ࠍ⿥߃㧘ᦨ߽ᄙ߆ߞߚ‫ޕ‬aPL 㓁ᕈ∝଀ߦኻߔࠆ᛫ಝ࿕≮ᴺߪ㧘ో૕ߣߒߡ⚂ 90%ߩ∝଀ߢᅧᆼ⛽ᜬߦᚑഞߒߚ㧚aPL ߩ⒳㘃㧘᛫૕ଔߩᄙኦ㧘޽ࠆ޿ߪࠕࠗ࠰࠲ࠗࡊ೎ߩᴦ≮ᚑ❣ߪ㧘ฦጀ೎㑆ߢߩᏅߪߥߊห╬ߦ⦟ᅢߢ޽ߞߚ㧚ห⒳఺∉⇣Ᏹߦኻߔࠆᄦ࡝ࡦࡄ⃿↪޿ߚ఺∉≮ᴺߪ㧘⚂ 70%ߩᚑഞ₸ߢ޽ߞߚ㧚ห⒳఺∉⇣Ᏹߣ⸻ᢿߔࠆᬌᩏᣇᴺ࡮ၮḰࠍߐࠄߦᬌ⸛ߔࠆᔅⷐ߇޽ࠆ㧚㧭㧚⎇ⓥ⋡⊛

ߦᒰ㒮୶ℂᆔຬળߩᛚ⹺ࠍᓧߚ㧚 ᅧᆼೋᦼߩᵹ↥ࠍ➅ࠅ㄰ߔਇ⢒∝㧔෻ᓳ޽ࠆ޿㧝㧚ᬌᩏ㗄⋡ߪ⠌ᘠᵹ↥㧦RSA㧕ߩේ࿃ߪᄙጘߦᷰߞߡ޿ࠆ߇㧘 㧝㧕ࠬࠢ࡝࡯࠾ࡦࠣᬌᩏ㧦ሶችᒻᘒ࡮ᨴ⦡૕࡮․ߦ఺∉ቇ⊛࿃ሶ߇㑐ਈߔࠆ∛ᘒߪᧂߛቢోߦౝಽᴲ࡮ಝ࿕࿃ሶߥߤߩ৻⥸⊛ᬌᩏߦട߃㧘ߪ⸃᣿ߐࠇߡ߅ࠄߕ㧘ታ㓙ߩ⥃ᐥߦ㓙ߒߡ㧘ߘߩએਅߩᬌᩏࠍⴕߞߚ㧚᛫ DNA ᛫૕㧘᛫ᩭ▤ℂᜰ㊎߇ቯ߹ߞߡ޿ߥ޿ߩ߇⃻⁁ߢ޽ࠆ㧚᛫૕㧘᛫ cardiolipin-IgG ߅ࠃ߮ IgM ᛫૕ ߘߎߢᧄ⎇ⓥߢߪ㧘RSA ߦ߅ߌࠆⴊᶧಝ࿕⇣Ᏹ㧘

㧔aCL-IgG㧘-IgM㧕㧘᛫ cardiolipin Ǫ2-GP1

޽ࠆ޿ߪ⥄Ꮖ఺∉ߥࠄ߮ߦห⒳఺∉⇣Ᏹߩሽ࿷᛫૕㧔Ǫ2-GP1㧕㧘

ࠍ᣿ࠄ߆ߦߒ㧘ߘࠇࠄࠍᬌ಴ߔࠆㆡಾߥᬌᩏᴺ㧘᛫ phosphatidylserine-IgG㧘-IgM ᛫૕߅ࠃ߮ലᨐ⊛߆ߟ୘೎⊛ߥᴦ≮ᴺߩ⏕┙ࠍ⋡ᜰ

㧔aPS-IgG㧘-IgM㧕㧘ߔ㧚᛫ phosphatidylethanolamine-IgG㧘-IgM
᛫૕㧔aPE-IgG㧘-IgM㧕㧘lupus㧮㧚⎇ⓥኻ⽎ߣᣇᴺanticoagulant㧔LA㧕㧘protein-C ߅ࠃ߮-S ᅧᆼ 12 ㅳ߹ߢߩᅧᆼೋᦼ⥄ὼᵹ↥ࠍ 2 ࿁એ਄ᵴᕈ㧔᛫ේ㊂㧕㧘߅ࠃ߮ⴊᶧಝ࿕╙ XII ࿃ሶ㧚➅ࠅ㄰ߒߡ޿ࠆߚ߼ߦ㧘ේ࿃♖ᩏ࡮ട≮ࠍ⋡⊛ߣߥ߅㧘aPL ᛫૕ଔߩ್ቯၮḰߪ㧘ታ᷹୯ 95ߒߡᘏᕺකᄢ∛㒮࡮ਇ⢒∝ᄖ᧪ࠍฃ⸻ߒߚ∝଀ࠍ

ޯ99 ࡄ࡯࠮ࡦ࠲ࠗ࡞ࠍᒙ㓁ᕈ㧘99 ࡄ࡯࠮ኻ⽎ߣߒ㧘หᗧࠍᓧߚ߁߃ߢ㧘એਅߦ␜ߔᬌᩏ࡮ࡦ࠲ࠗ࡞એ਄ࠍᒝ㓁ᕈߣߒߚ㧚ᴦ≮ࠍᣉⴕߒߚ㧚ߥ߅㧘ߘߩᣉⴕߦ㓙ߒߡߪ੐೨㧞㧕․ᱶᬌᩏ㧦਄⸥ࠬࠢ࡝࡯࠾ࡦࠣᬌᩏߢએ਄

103ࠍ⹺߼ߥ޿႐ว㧘એਅߩᬌᩏࠍⴕߞߚ㧚㧟㧚ኻ⽎∝଀ߩౝ⸶natural killer㧔NK㧕⚦⢩ᵴᕈ㧘᛫ HLA 㧝㧕ࠬࠢ࡝࡯࠾ࡦࠣᬌᩏߩ⇣Ᏹ಴⃻㗫ᐲ㧦2004᛫૕㧘ᄦᇚ㑆ᷙว࡝ࡦࡄ⃿෻ᔕ㧔MLR㧕㧘ᐕ 1 ᦬߆ࠄ 2008 ᐕ 12 ᦬߹ߢߦೋ⸻ฃ⸻ߒ

߅ࠃ߮ Th1/Th2 ⚦⢩Ყ㧚

ߚ 415 ∝଀㧔ේ⊒ᕈ 317 ଀㧦⛯⊒ᕈ 98 ଀㧘㧞㧚ᴦ≮ᣇᴺߩㆬᛯၮḰ෻ᓳᵹ↥ 219 ଀㧦⠌ᘠᵹ↥ 196 ଀㧕ࠍኻ⽎㧝㧕᛫ಝ࿕≮ᴺ㧦৻⥸⊛ᬌᩏߢߪ⇣Ᏹࠍ⹺߼ߥߣߒ㧚એਅߩ 9 㗄⋡ߦߟ޿ߡᬌ⸛ߒߚ㧚ሶ޿∝଀ߦߟ޿ߡ㧘⥄Ꮖ᛫૕ߥࠄ߮ߦ aPLችᒻᘒ㧘ᨴ⦡૕㧘ౝಽᴲ㧘ANA㧘aDNA㧘ߩᬌᩏ⚿ᨐߦࠃࠅ㧘ේೣ⊛ߦએਅߩၮḰߦaPLs㧘proein-C㧘protein-S㧘ⴊᶧಝ࿕╙ߒߚ߇ߞߡᴦ≮ߒߚ㧦㧔A㧕Ǫ2-GP1 ࠍ㒰޿

XII ࿃ሶ㧚ߚ৻ߟߩ㗄⋡ߩߺ㓁ᕈࠍ␜ߔ∝଀ߢ㧘߆ߟ 㧞㧕aPL ಴⃻㗫ᐲߣ᛫ಝ࿕≮ᴺߩᴦ≮ᚑ❣㧦LA ᒙ㓁ᕈ㧘aCL-IgM ޽ࠆ޿ߪ aPS-IgM

2005 ᐕ 11 ᦬߆ࠄ 2009 ᐕ 7 ᦬߹ߢߩ㑆ߩߩߺ㓁ᕈߩ∝଀ߦኻߒߡߪ㧘ࠕࠬࡇ࡝ࡦࠍaPL 㓁ᕈ 131 ∝଀㧔ේ⊒ᕈ 92 ଀㧦⛯⊒ᕈන⁛ᛩਈߒߚ㧚㧔B㧕LA ᒝ㓁ᕈ㧘Ǫ2-GP139 ଀㧕ࠍኻ⽎ߦ㧘
㧔㧝㧕aPL ߩ಴⃻㗫ᐲࠍ㧘㓁 ᕈ 㧘 aCL-IgG 㓁 ᕈ 㧘aPS-IgG 㓁 ᕈ 㧘

᛫૕⒳೎㧘isotype ೎߅ࠃ߮᛫૕ଔ೎ߦᬌaPE-IgG ޽ࠆ޿ߪ IgM 㓁ᕈ㧘޽ࠆ޿ߪੑ

⸛ߒߚ㧚㧔㧞㧕᛫ಝ࿕≮ᴺߦࠃࠆᅧᆼᏫ⚿ߟએ਄ߩ㗄⋡߇㓁ᕈߩ∝଀ߦኻߒߡߪ㧘ࠕࠍ㧘ߘࠇࠄߩᬌᩏ⚿ᨐߣ૬ߖߡᲧセᬌ⸛ߒࠬࡇ࡝ࡦ㧗ᩊ⧠ḡ㧗ࡋࡄ࡝ࡦߩ૬↪ࠍⴕߚ㧚ߞߚ㧚ߥ߅㧘ࠕࠬࡇ࡝ࡦ㧔100mg/ᣣ㧕ߪᅧ㧟㧕LIT ߩᴦ≮ᚑ❣㧦2002 ᐕ 1 ᦬߆ࠄ 2007ᆼ೨߆ࠄ᦯↪ߒ㧚ᅧᆼ 32 ㅳ߹ߢᛩਈߒߚ㧚ᐕ 12 ᦬߹ߢ㑆ߦ LIT ࠍᣉⴕߒߚ 91 ∝଀ᩊ⧠ḡ㧔9g/ᣣ㧕ߪᅧᆼ೨߆ࠄ᦯↪ߒ㧚ᅧᆼࠍኻ⽎ߦ㧘㧔㧝㧕LIT ߦࠃࠆᅧᆼᏫ⚿ߣหᚑ┙ᓟߦਛᱛߒߚ㧚ࡋࡄ࡝ࡦ㧔5,000 න૏⒳఺∉㑐ㅪߩᬌᩏ⚿ᨐࠍ૬ߖߡᲧセᬌ⸛x2 ࿁/ᣣ㧕ߪ⢝ྙ⏕⹺ᓟ߆ࠄᅧᆼ 37 ㅳ߹ߢߒߚ㧚
㧔㧞㧕LIT ᓟߩ 71 ∝଀ࠍኻ⽎ߦ aPL㧘ᛩਈߒߚ㧚

ANA㧘aDNA ߩ㓁ォൻ₸ࠍᬌ⸛ߒߚ㧚 㧞㧕ᄦ࡝ࡦࡄ⃿఺∉≮ᴺ㧦ࠬࠢ࡝࡯࠾ࡦࠣᬌᩏ

104ߢ⇣Ᏹࠍ⹺߼ߥ޿∝଀ߦߟ޿ߡ㧘ห⒳఺∉㧯㧚⎇ⓥ⚿ᨐ

㑐ㅪߩ․ᱶᬌᩏ⚿ᨐߦࠃࠅ㧘ේೣߣߒߡ㧝㧚ࠬࠢ࡝࡯࠾ࡦࠣᬌᩏߩ⇣Ᏹ಴⃻㗫ᐲ

MLR-BEૐ୯㧘᛫HLA᛫૕㒶ᕈ㧘NK⚦⢩ ේ⊒ᕈ㧘⛯⊒ᕈߦ߆߆ࠊࠄߕ㧘૗ࠄ߆ߩ aPLᵴᕈ㜞୯㧘޽ࠆ޿ߪTh1/Th2 Ყ੣ㅴߩߤࠇ߇㓁ᕈߢ޽ߞߚ∝଀߇ฦ‫ޘ‬70.7%㧘74.5%ߢ޽ࠅ

߆ߦ⹥ᒰߔࠆ∝଀ߦኻߒߡᄦ㧔ࡄ࡯࠻࠽ᦨ߽ᄙ߆ߞߚ㧚ᰴ޿ߢ㧘ౝಽᴲ⇣Ᏹ㧔20.7%㧦

࡯㧕࡝ࡦࡄ⃿ࠍ↪޿ߚ఺∉≮ᴺ㧔LIT㧕ࠍ

10.7%㧕㧘ᨴ⦡૕⇣Ᏹ㧔6.0%㧦6.3%㧕㧘ⴊᶧಝ࿕╙ⴕߞߚ㧚࡝ࡦࡄ⃿ߪ᡼኿✢ಣℂᓟ㧘1ޯ5 xXII ࿃ሶ㧔7.4%㧦6.4%㧕ߢ޽ߞߚ㧚ᵹ↥࿁ᢙ೎㧔2107୘/↢㘩᳓ 1mlߦ⺞ᢛߒ㧘ᅧᆼ೨ߦ 2 ㅳ࿁㧘3 ࿁㧘3 ࿁એ਄㧕ߦߺࠆߣ㧘aPLs 㓁ᕈ㗫ᐲߪ㑆Ფߦ 3 ࿁㧘ᅧᆼᚑ┙ᓟߦߐࠄߦㅊട఺∉ߘߩ࿁ᢙߩᄙኦߦ߆߆ࠊࠄߕ⚂ 70%એ਄ߢ޽ߞ

ߣߒߡᅧᆼ 12 ㅳ߹ߢ 2 ㅳ㑆Ფߦ਄⣨⊹ౝߚ߇㧘ᨴ⦡૕⇣Ᏹߩ㗫ᐲߪ㧘ේ⊒ᕈߩ႐ว㧘ᵹ↥

ߦធ⒳ߒߚ㧚

࿁ᢙ߇Ⴧ߃ࠆߦߟࠇߡჇടߒߚ㧔3.9%㧦7.8%㧦

10.7%㧕㧚㧞㧚aPL ಴⃻㗫ᐲᆼ⛽ᜬ₸ߦ᦭ᗧᏅߪ⹺߼ߥ߆ߞߚ㧚 㧟㧕isotype ೎ߩᴦ≮ᚑ❣㧦IgG 㓁ᕈ଀ߣ IgM

 㧝㧕᛫૕⒳೎ߩ಴⃻㗫ᐲ㧦8 ⒳㘃ߩ aPLs ߩਛ㓁ᕈ଀ߩᅧᆼ⛽ᜬ₸ߪฦ‫ޘ‬91.2%㧦90.0%ߢ

ߢᦨ߽಴⃻㗫ᐲ߇㜞߆ߞߚߩߪ㧘ో૕㧔ේ޽ࠅ㧘ਔ⠪ߩ㑆ߦ᦭ᗧߥᅧᆼ⛽ᜬ₸ߩᏅߪ⊒ ᕈ + ⛯ ⊒ ᕈ 㧕 ߣ ߒ ߡ ߺ ࠆ ߣ aPS-IgM⹺߼ߥ߆ߞߚ㧚

㧔55.7%㧕㧘ᰴ޿ߢ aCL-IgM㧔54.2%㧕㧘LA㧠㧕aPL 㓁ᕈᢙ೎ߩᴦ≮ᚑ❣㧦aPL ߩන⁛㓁

㧔35.9%㧕ߣ⛯߈㧘ᦨ߽ૐ޿ߩߪǪ2-GP1ᕈ଀ߣⶄᢙ㓁ᕈ଀ߩᅧᆼ⛽ᜬ₸ߪฦ‫ޘ‬

㧔0.3%㧕ߢ޽ߞߚ㧚ߎߩ௑ะߪේ⊒ᕈߣ⛯

91.2%㧦91.5%ߢ޽ࠅ㧘ਔ⠪ߩ㑆ߦ᦭ᗧߥ⊒ᕈߦಽߌߡߺߡ߽ᄌࠊࠅߪߥߊ㧘߹ߚߎᅧᆼ⛽ᜬ₸ߩᏅߪ⹺߼ߥ߆ߞߚ㧚ߩਔ⠪㑆ߩ aPL ಴⃻㗫ᐲߦ᦭ᗧᏅߪ⹺߼ࠄ 㧡㧕ᴦ≮ᴺ೎ߩᴦ≮ᚑ❣㧦ࠕࠬࡇ࡝ࡦන⁛≮ᴺࠇߥ߆ߞߚ㧚

㧔LDA㧕ߣࠕࠬࡇ࡝ࡦ+ࡋࡄ࡝ࡦ㧔+ᩊ⧠ḡ㧕 㧞㧕᛫૕ଔ೎ߩ಴⃻㗫ᐲ㧦ో૕ߣߒߡߺࠆߣ㧘

૬↪≮ᴺ㧔LDA+Hep㧕ࠍ㧘isotype ೎޽ࠆ޿ߕࠇߩ aPL ߦ߅޿ߡ߽ᒙ㓁ᕈߩ㗫ᐲ߇ᒝ޿ߪ㓁ᕈ᛫૕ᢙ೎ߦᲧセߒߚ㧚޿ߕࠇߦ߅

㓁ᕈߩ㗫ᐲࠍᄢ߈ߊ਄࿁ࠅ㧘aPS-IgM ߢߪ޿ߡ߽㜞޿ᅧᆼ⛽ᜬ₸ߢ޽ࠅ㧘ᦨ߽ૐ޿߽ฦ ‫ ޘ‬38.9%㧦 16.8% 㧘 aCL-IgM 㧔 38.2% 㧦ߩߢ߽ LDA ⟲ߩ IgG 㓁ᕈ଀ߩ 80.0%ߢ޽

16.0%㧕㧘LA㧔34.4%㧦1.5%㧕ߢ޽ߞߚ㧚ߎߞߚ㧚ߘࠇࠄ aPL-profile ߣਔᴦ≮ᴺߦࠃߩ௑ะߪේ⊒ᕈߣ⛯⊒ᕈߣߦಽߌߡߺߡ߽ࠆᅧᆼ⛽ᜬ₸ߣߩ㑆ߦ᦭ᗧߥ㑐ㅪᕈߪ⹺ᄌࠊࠅߪߥ߆ߞߚ㧚߼ߥ߆ߞߚ㧚㧟㧚᛫ಝ࿕≮ᴺߩᴦ≮ᚑ❣

㧠㧚LIT ߩᴦ≮ᚑ❣

 ᛫ಝ࿕≮ᴺࠍⴕߞߚ aPL 㓁ᕈ 131 ଀ਛ 82 ଀߇

 LIT ࠍⴕߞߚ 91 ଀ߩਛ 54 ଀ߦᅧᆼ߇ᚑ┙ߒ㧘ᅧᆼߒߚ㧚ߘߩਛ㧘ᅧᆼ߇ᚑഞ⵰ߦ⛽ᜬߐࠇߚߩ

ߘߩ߁ߜ 39 ଀㧔72.2%㧕ߩᅧᆼ⛽ᜬߦᚑഞߒߚ㧚ߪ 74 ଀㧘߹ߚᵹ↥ߦ⚳ࠊߞߚ∝଀߇ 8 ଀ߢ޽ߞ15 ଀߇ᵹ↥ߒߚ߇㧘⛐Ძᨴ⦡૕ࠍᬌᩏߢ߈ߚߩߪߚ㧚ᵹ↥଀ਛ 1 ଀ߦߪ⛐Ძߩᨴ⦡૕⇣Ᏹࠍ⹺߼ߚ㧚

4 ଀ߢ޽ࠅ㧘ߘߩਛ 2 ଀ߪ⇣Ᏹߢ޽ߞߚ㧚LIT ೨ߒߚ߇ߞߡ㧘ᴦ≮ᚑ❣ߪߘߩ 1 ଀ࠍ㒰޿ߚ 81 ଀

ᓟߢߩห⒳఺∉㑐ㅪߩ․ᱶᬌᩏ⚿ᨐ㧔MLR-BE ߩࠍኻ⽎ߦᬌ⸛ߒߚ㧚᦭ή㧘᛫ HLA ᛫૕㓁ォߩ᦭ή㧘NK ⚦⢩ᵴᕈߩ 㧝㧕᛫૕⒳೎ߩᴦ≮ᚑ❣㧦޿ߕࠇߩ aPL 㓁ᕈ଀ᄌേ㧘޽ࠆ޿ߪ Th1/Th2 Ყߩᄌേ㧕ߣᅧᆼ⛽ᜬߦ߅޿ߡ߽ᅧᆼ⛽ᜬ₸ߪ㜞ߊ㧘ᦨ߽ૐ޿߽

₸ߣߩ㑆ߦ᦭ᗧߥ㑐ㅪᕈߪ⹺߼ߥ߆ߞߚ㧚߹ߚ㧘ߩߢ߽ aPS-IgM ߩ 88.1%ߢ޽ࠅ㧘ઁߩ aPL

LIT ᓟߩ᛫૕಴⃻ߩ᦭ήࠍ⛮⛯⊛ߦᬌᩏߒᓧߚ

ߩߘࠇߪ 90%ࠍ⿥߃ߡ޿ߚ㧚aPL ߩ⒳㘃ߦ71 ଀ߦ߅޿ߡ㧘aCL-IgG ߇ 14 ଀㧔19.7%㧕ߢ㓁ࠃࠆᅧᆼ⛽ᜬ₸ߦ᦭ᗧᏅߪ⹺߼ߥ߆ߞߚ㧚ォൻߒߚ㧚ߘߩઁ㧔ANA㧘Ǫ2-GP1㧘LA㧕ߪฦ 1 㧞㧕᛫૕ଔ೎ߩᴦ≮ᚑ❣㧦޿ߕࠇߩ aPL ߦ߅޿଀ߢ޽ࠅ㧘aDNA ߇㓁ォൻߒߚ଀ߪ⹺߼ߥ߆ߞߚ㧚ߡ߽㧘ᒙ㓁ᕈ޽ࠆ޿ߪᒝ㓁ᕈߦ߆߆ࠊࠄߕ

aCL-IgG ߇㓁ォൻߒߚ 14 ଀ਛ 9 ଀㧔64.3%㧕ߪᅧᆼ⛽ᜬ₸ߪ㜞ߊ㧘ᦨ߽ૐ޿߽ߩߢ߽

1 ᐕᓟߦߪ㒶ᕈൻߒߚ㧚aPS-IgM ᒝ㓁ᕈߩ 82.9%ߢ޽ߞߚ㧚޿ߕࠇ
ߩ aPL ߦ߅޿ߡ߽㧘᛫૕ଔߩᄙኦߦࠃࠆᅧ

105㧰㧚⠨ኤᔕၮḰࠍ᳿߼ࠆߎߣߦࠃࠅ㧘৻ጀߩലᨐࠍᓧࠆߎ ㄭᐕ㧘⥄Ꮖ఺∉⇣Ᏹߣ㑐ㅪߔࠆ aPL ߩሽ࿷㧘޽ߣ߇ߢ߈ࠆߣᕁࠊࠇࠆ㧚ࠆ޿ߪⴊᶧಝ࿕࿃ሶߩ⇣Ᏹߥߤߦࠃࠆⴊᩖᕈ⚛
࿃߇ᵹ↥ේ࿃ߣߒߡᵈ⋡ߐࠇ㧘ߘࠇࠄߦኻߔࠆ᛫㧲㧚ஜᐽෂ㒾ᖱႎ

ಝ࿕≮ᴺߩ᦭ലᕈ߇ႎ๔ߐࠇߡ߈ߚ㧚ߒ߆ߒ㧘aPL  ߥߒ

ߩ⒳㘃㧘᛫૕ଔ㧘޽ࠆ޿ߪࠕࠗ࠰࠲ࠗࡊߩ⒳㘃ߥߤߣ᛫ಝ࿕≮ᴺߩ⒳㘃㧘޽ࠆ޿ߪᴦ≮ᚑ❣ߣߩ㑐

G㧚⎇ⓥ⊒⴫

ㅪߪᧂߛචಽߦᬌ⸛ߐࠇߡ߅ࠄߕਇ᣿ߥὐ߇ዋ

1㧚⺰ᢥ⊒⴫ߥߊߥ޿㧚1)

 ੹࿁ᬌ⸛ߒߚ∝଀ߢߪ㧘㓁ᕈ aPL ߩᢙ޽ࠆ޿ߪ

Mesenchymal to epithelial transition in theࠕࠗ࠰࠲ࠗࡊߦࠃࠅ LDA ≮ᴺߣ LDA+Hep ≮ᴺhuman ovarian surface epitheliumࠍ૶޿ಽߌࠆߎߣߦࠃߞߡ㧘޿ߕࠇ߽㜞޿ᅧᆼ⛽focusing on inclusion cysts.

ᜬ₸ࠍᓧߚ㧚ߒߚ߇ߞߡ㧘aPL ߩ IgM න⁛㓁ᕈ21㧦1209ޯ1214, 2009. ଀ ߢ ߪ LDA ≮ ᴺ ߛ ߌ ߢ ߽ ᦭ ല ߢ ޽ ࠅ 㧘2)

Oncol Rep

Omi H, Kawaguchi R, Tanaka T, et al..

aPL-profile ߦࠃߞߡߪ LDA+Hep ≮ᴺߪᔅߕߒ

Establishment of an immortalized human߽ᔅⷐߥ޿߆߽ߒࠇߥ޿㧚੹ᓟ㧘aPL ᛫૕ଔߥߤ

extravillous trophoblast cell line by߽ട๧ߒߚߐࠄߦ⹦⚦ߥ aPL-profile ߣᴦ≮ᴺ೎

retroviral infection of E6/E7/hTERT and itsߩ㑐ㅪࠍ⸃ᨆߔࠆ੍ቯߢ޽ࠆ㧚transcriptional profile during hypoxia and ߹ߚ㧘Უఽ㑆ߩห⒳఺∉ᔕ╵⇣Ᏹߦ⿠࿃ߔࠆᵹ

reoxygenation.

↥ߩሽ࿷߽⍮ࠄࠇߡ޿ࠆ߇㧘ߘࠇࠍᬌ಴ߔࠆㆡಾ

236, 2009. ߥᬌᩏ㧘ߘߒߡⴕࠊࠇߡ޿ࠆ LIT ߩ᦭ലᕈߩ⹏ଔ3)Int J Mol Med 23㧦229ޯ

Kawaguchi R, Tanaka T, et al. Priming ofߪቯ߹ߞߡ޿ߥ޿㧚

peripheral੹࿁ߩᬌ⸛ߢߪ㧘޿ߕࠇߩ․ᱶᬌᩏ߽᦭ᗧߥ㑐ㅪsensitizesᕈࠍ␜ߖߥ߆ߞߚ㧚LIT ೨ᓟߩ IDO ߩ⊒⃻ߥߤ㧘

indolamineᣂߒ޿ࡑ࡯ࠞ࡯ߣߥࠅᓧࠆ߽ߩࠍᬌ⸛ߔࠆ੍ቯ

without affecting IFN-gamma signaling.J

ߢ޽ࠆ㧚

Reprod Immunol 77 : 117-125, 2008.
4)monocytes

withprolactin

IFN-gamma-mediated
2,3-dioxygenase

expression

Itoh H, Tanaka T, et al. A case-control㧱㧚⚿⺰

study of the association between urinary ੹࿁ߪᤓᐕᐲߦ⛯ߊ╙ 2 ᐕᐲߩਛ㑆ႎ๔ߣߒߡ㧘

cadmium concentration and endometriosis⃻࿷߹ߢߦ⫠㓸ߒߚ RSA ∝଀ߦߟ޿ߡ㧘ߘߩේin infertile Japanese women.

࿃ߩ㗫ᐲ߅ࠃ߮ᴦ≮ᚑ❣ࠍਛᔃߦ߹ߣ߼ߚ㧚aPL

the Total Environment 2008㧧402㧦171ޯ㓁ᕈ଀ߢߪ᛫ಝ࿕≮ᴺߦࠃࠅ⚂ 90%ߩ㜞޿ᅧᆼ175㧚⛽ᜬ₸߇ᓧࠄࠇ㧘ห⒳఺∉⇣Ᏹߣᕁࠊࠇࠆ∝଀ߦ

106

Okamoto S, Tanaka T, et al..

5)

Science of

Ueda K, Tanaka T, et al. Association ofኻߔࠆ LIT ߪ⚂ 70%ߩᅧᆼ⛽ᜬ₸ߢ޽ߞߚ㧚

extracellurar matrix metalloprotease ᛫ಝ࿕≮ᴺ޽ࠆ޿ߪ఺∉≮ᴺߩࠃࠅ෩ኒߥㆡ

inducer in endometrial carcinoma with

patient outcomes and clinicopathogenesis
using monoclonal antibody 12C3. Oncol
Rep 17㧧731-735, 2007㧚 6)3.

ߥߒߘߩઁ
ߥߒ

Takao M, Tanaka T, et al. Increased
synthesis of indolamine-2,3,-dioxygenase
protein is positively associated with
impaired survival in patients withserous-type, but not with other types of,ovarian  cancer.

Oncol Rep 17㧧

1333-1339, 2007㧚
2㧚ቇળ⊒⴫1)㜞ᯅ⛗㉿㧘Ꮉญ㉿ᕺ㧘↰ਛᔘᄦ㧘ઁ㧚ਇᅧ∝ߣਇ⢒∝㧘ߘߩ⒖ⴕ∝଀ߩ⥃ᐥ⊛⸃ᨆ㧚 ╙61 ࿁  ᣣ ᧄ ↥ ⑼ ᇚ ੱ ⑼ ቇ ળ ቇ ⴚ ⻠ Ṷ ળ
2009.04㧔੩ㇺ㧕㧚2)

Takahashi E, Kawaguchi R, Tanaka T, etal. Clinical analyses for transitional casesof infertility and recurrent pregnancy loss. 15th

Conference

FederationofofPlacentalInternationalAssociation

2009.10㧔Adelaide, Australia㧕㧚
3)

Umehara N, Kawaguchi R, Tanaka T, et al.
Therapeutic outcome in recurrent
spontaneous abortions withantiphospholipid antibodies ޯ The
influence of titers, varieties, isotypes,
positive numbers of antiphospholipidantibodiesޯ.  15th Conference ofInternational Federation of Placental
Association 2009.10㧔Adelaide, Australia㧕㧚

㧴㧚⍮⊛⽷↥ᮭߩ಴㗿࡮⊓㍳⁁ᴫ㧔੍ቯࠍ฽߻‫ޕ‬㧕
1. ․⸵ขᓧ
ߥߒ
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