ᐔᚑ 㪉㪉 ᐕᐲෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄䋨ᚑ⢒∔ᖚస᦯╬ᰴ਎ઍ⢒ᚑၮ⋚⎇ⓥ੐ᬺ䋩㩷ಽᜂ⎇ⓥႎ๔ᦠ
ಽᜂ⺖㗴䋺᛫䊥䊮⢽⾰᛫૕䈮䉋䉎ਇ⢒∝⊒∝䊜䉦䊆䉵䊛䈮㑐䈜䉎⎇ⓥ
⎇ⓥಽᜂ⠪㩷 ⮮੗㩷 ⍮ⴕ㩷 ᧲੩ᄢቇ↥⑼ᇚੱ⑼ቇಎᢎ᝼
⎇ⓥⷐᣦ
⠌ᘠᵹ↥䈱䊥䉴䉪䊐䉜䉪䉺䊷䈪䈅䉎᛫䊥䊮⢽⾰᛫૕(aPL)䈱ਛ䈪䇮․䈮E2GPI ଐሽᕈ aPL 䈱䇮ⴊᶧಝ࿕⇣Ᏹએᄖ䈱ᵹ↥⊒∝䊜䉦䊆䉵䊛䈮䈧䈇䈩䇮CD1d ᛫ේ䈮ᵈ⋡䈚䈩⎇ⓥ䈚䈩䈇䉎䇯CD1d ᛫ේ䈲䊍䊃⊕ⴊ⃿᛫ේ(HLA)㘃ૃ䈱⤑Ⱞ⊕⾰䈪䈅䉍䇮⥄Ꮖ䈱䊥䊮⢽⾰䉕฽䉃䊥䊮⢽⾰䉕ឭ␜䈚䇮ೋᦼ䈱⢝⋚ extravillous trophoblast ⴫㕙䈮⊒⃻䈚䈩䈇䉎䇯ᤓᐕᐲ䉁䈪䈱⎇ⓥ䈮䈍䈇䈩䇮ᚒ䇱䈲䇮᛫E 2GPI ᛫૕䈏䇮PS-E 2GPI ⶄว૕䈫⚿ว䈚䈢 trophoblast ⴫㕙䈱 CD1d 䈫㑆ធ⊛䈮⚿ว 䈚䇮䈠䈱 ⋧ ੕૞↪䈮䉋䈦䈩 CD1d 䈱᨞ᯅ෻ᔕ 䈏⿠䈖䉍䇮 CD1d 䉕⊒⃻䈜䉎
trophoblast 䈎䉌䈱 IL-12 ⺃ዉ䈏⿠䈖䉎䈖䈫䉕᣿䉌䈎䈮䈚䇮䉁䈢䇮䈖䈱⃻⽎䈏䇮ᖚ⠪ⴊᷡ䈪䉅⺃ዉ䈘䉏䉎䈖䈫䉅⏕⹺䈚䈢䇯䈘䉌䈮䇮䊍䊃⣕⪭⤑䊥䊮䊌⃿䈎䉌 iNKT ⚦⢩䉕⺃ዉ䈚䇮CD1d 䉕ᒝ೙⊒⃻䈘䈞䈢⛐Ძ≸⚦⢩ᩣ(JEG/CD1d)䈫౒ၭ㙃䈚䇮䊍䊃⣕⪭⤑ iNKT ⚦⢩䈏䇮CD1d 䉕੺䈚䈩⛐Ძ⚦⢩䈎䉌䈱Ἳ∝ᕈ䉰䉟䊃䉦䉟䊮 IL12 䈱↥↢䉕⺃ዉ䈜䉎䈖䈫䉕⸽᣿䈚䈢䇯ᧄᐕᐲ䈲䇮trophoblast਄䈱 CD1d 䈫⣕⪭⤑ iNKT 䈫䈱⋧੕૞↪䈏䇮᛫E 2GPI ᛫૕䈱ሽ࿷䈮䉋䉍䇮䈬䈱䉋䈉䈮ᄌൻ䈚䇮ዪᚲ䈮䈍䈔䉎ᅧᆼ఺∉෻ᔕ䈏䈬䈱䉋䈉䈭ᓇ㗀䉕ᬌ⸛䈜䉎䈖䈫䈫䈚䈢䇯iNKT ⚦⢩䉕⺃ዉ䈚䈢䊍䊃⣕⪭⤑䊥䊮䊌⃿䈫䇮JEG/CD1d ⚦⢩䈫䈱౒ၭ㙃䈮䇮᛫E 2GPI ᛫૕䉁䈢䈲䉮䊮䊃䊨䊷䊦 IgG 䉕ᷝട䈚䇮Il-12䇮Interferon (IFN)-J⺃ዉ䉕ⷰኤ䈚䈢䇯䈠䈱⚿ᨐ䇮JEG/CD1d ⚦⢩䈪䈲䇮18 ᤨ㑆ᓟ䈮᛫E2GPI ᛫૕ᷝട⟲䈱 IL12 ↥↢䈏㒶ᕈ䉮䊮䊃䊨䊷䊦 IgG ᷝട⟲䈱 3 ୚䈮䉁䈪᦭ᗧ䈮Ⴧട
䈚䈢䇯JEG 䈪䈲᛫E2GPI ᛫૕ሽ࿷ਅ䈪䉅䇮IL12 ↥↢䈱Ⴧട䉕⹺䉄䈭䈎䈦䈢䇯IFN-J䈱↥↢䈮䈧䈇䈩䈲䇮᛫E2GPI ᛫૕ᷝട⟲䈫㒶ᕈ䉮䊮䊃䊨䊷䊦 IgG ᷝട⟲䈫䈱Ყセ䈪䇮IL12 䈫⇣䈭䉍 JEG䇮JEG/CD1d ਔ⠪䈮䈍䈇䈩䇮᛫E2GPI ᛫૕ᷝട⟲䈪䇮18 ᤨ㑆ᓟ䈮 IFN-J䈱↥↢䈏Ⴧട䈜䉎௑ะ䈮䈅䈦䈢䈏䇮JEG/CD1d ⚦⢩䈮䈍䈇䈩䈱䉂᦭ᗧᏅ䉕⹺䉄䈢䇯એ਄䉋䉍䇮᛫E2GPI ᛫૕䈏ሽ࿷䈜䉎䈫䇮᛫E2GPI ᛫૕䈮䉋䉎 CD1d 䈱᨞ᯅ෻ᔕ䈪↥↢䈘䉏䈢
IL12 䈏 ⣕ ⪭ ⤑ iNKT ⚦ ⢩ 䉕 ᵴ ᕈ ൻ 䈘 䈞 䇮 iNKT ⚦ ⢩ 䈎 䉌 䈱 IFN-J ಽ ᴲ 䈏 Ⴧ ട 䈚 䈩trophoblast ਄䈱 CD1d ⊒⃻䉕Ⴧട䈘䈞䇮䈘䉌䈮 CD1d ⊒⃻⚦⢩䈎䉌䈱 IL12 ಽᴲ䉕ଦㅴ䈜䉎䈫䈇䈉䉰䉟䉪䊦䈏ᔅⷐએ਄䈮ᵴᕈൻ䈘䉏䇮䈖䉏䈮䉋䉍䇮Უ૕⢝ఽႺ⇇䈮䈍䈔䉎ዪᚲ䈱Ἳ∝䈏ㆊ೾䈫䈭䉍䇮ᵹ↥䉕ᒁ䈐⿠䈖䈜䈖䈫䈏␜ໂ䈘䉏䈢䇯䌁䋮⎇ⓥ⋡⊛᛫䊥䊮⢽⾰᛫૕(aPL)䈲ਇ⢒∝䈱䊥䉴䉪䊐䉜䉪䉺䊷䈪䈅䉎䇯aPL 䈏㑐ਈ䈜䉎ᵹ↥䈪䈲ⴊᶧಝ࿕⇣Ᏹ䉕੺䈜䉎䊜䉦䊆䉵䊛䈏ឭ໒䈘䉏䈩䈍䉍䇮⢝⋚ⴊ▤ౝ䈱ⴊᩖᒻᚑ䈮䉋䉍⢝⋚ᯏ⢻䈏㓚ኂ䈘䉏䈩䇮ᵹᱫ↥䈏⿠䈖䉎䈫䈘䉏䈩䈇䉎䇯䈚䈎䈚䇮aPL 䈲⢝⋚ⴊ▤ᧂᒻᚑ䈱ᅧᆼೋᦼᵹ↥䉕෻ᓳ䈜䉎⠌ᘠᵹ↥䈮䉅㑐ㅪᕈ䈏ႎ๔䈘䉏䈩䈍䉍䇮䈠䈱ᵹ↥⊒∝䊜䉦䊆䉵䊛䈲ᔅ䈝䈚䉅᣿䉌䈎䈮䈭䈦䈩䈇䈭䈇䇯aPL 䈱ਛ䈪䉅䇮ਇ⢒∝䉕ᒁ䈐⿠䈖䈜ജ䈏․䈮ᒝ䈇䈫⠨䈋䉌䉏䈩䈇䉎E2glycoproteinΣ䋨E2GPI䋩ଐሽᕈ aPL 䈲䇮㒶ᕈ⩄㔚䉕ᜬ䈧䊥䊮⢽⾰䈫⚿ว䈚䈢 E2GPI 䈫෻ᔕ䈚䇮ⴊᩖᒻᚑ䉕⺃ዉ䈜䉎䈖䈫䈮䉋䉍䇮ਛᦼᵹ↥䉕⊒∝䈘䈞䉎䈫䈘䉏䈩䈇䉎䈏䇮ᦨㄭ䇮trophoblast 䈻䈱⋥ធ⊛䈭⚦⢩்ኂ૞↪䈮䉋䉎ೋᦼ⠌ᘠᵹ↥⊒∝ᯏォ䉅ႎ๔䈘
䉏䈢䇯

135

CD1d ᛫ේ䈲䇮HLA ㄭற㗔ၞ䈪䉮䊷䊄䈘䉏䉎
HLA 㘃ૃ᛫ේ䈪䈅䉍䇮trophoblast 䈮⊒⃻䈘䉏䈩䈇䉎䇯䈖䈱᛫ේ䈲 HLA class I ᛫ේ䈫䈾䈿ห᭽䈱᭴ㅧ䉕ᜬ䈤䇮invariant natural killer T cell (iNKT)䈮
⹺⼂䈘䉏䇮䈠䉏䈮䉋䉍෺ᣇ䈱⚦⢩䈎䉌ಽᴲ䈘䉏䉎 Thelper 1 (Th1)䉰䉟䊃䉦䉟䊮䉕੺䈚䈢ዪᚲἻ∝෻ᔕ䉕⺃ዉ䈜䉎௛䈐䉕᦭䈚䈩䈇䉎䇯ታ㓙䇮↥ᇚੱ⑼㗔ၞ䈮䈍䈇䈩䉅䇮ሶች㗪▤਄⊹⚦⢩䈏 CD1d ᛫ේ䉕⊒⃻䈚䇮ዪᚲ䈱 iNKT 䈭䈬䈱఺∉⚦⢩䈫䈱⋧੕૞↪䈮䉋䉍䇮☼⤑䈱ᗵᨴ㒐ᓮ෻ᔕ䈮㊀ⷐ䈭㑐ਈ䉕䈚䈩䈇䉎䈖䈫䈏䉒䈎䈦䈩䈇䉎䇯৻ᣇ䇮iNKT ⚦⢩䈲ሶች⣕⪭⤑䈮䉅ሽ࿷䈜䉎䈖䈫䈏䉒䈎䈦䈩䈍䉍䇮trophoblast 䈏CD1d ᛫ේ䉕⊒⃻䈚䈩䈇䉎䈖䈫䈫ว䉒䈞䈩䇮ᅧᆼ఺∉䈮 CD1d ᛫ේ䈏㊀ⷐ䈭௛䈐䉕䈚䈩䈇䉎䈖䈫䈏⠨䈋䉌䉏䉎䇯䉁䈢䇮CD1d ಽሶ䈲䇮᛫ CD1d ᛫૕䈮䉋䉍ಽሶ᨞ᯅ෻ᔕ䉕䈍䈖䈚䇮⚦⢩ౝ䈱䊥䊮㉄ൻ䉦䉴䉬䊷䊄䈮䉋䉍䇮interleukin (IL)-12 䈭䈬䈱䉰䉟䊃䉦䉟䊮ಽᴲ䉕⺃ዉ䈚䇮Th1 ෻ᔕ䉕ዉ䈒䈖䈫䉅⍮䉌䉏䈩䈇䉎䇯䈘䉌䈮䇮human leukocyte antigen (HLA)䈏䊕䊒䉼䊄䉕⚦⢩⴫㕙䈮ឭ␜䈜䉎䈱䈫⇣䈭䉍䇮CD1d ᛫ේ䈲䊥䊮⢽⾰䉕ឭ␜䈜䉎૞↪䉕᦭䈚䈩䈇䉎䈖䈫䈎䉌䇮ਇ⢒∝䈱ේ࿃䈪䈅䉎᛫䊥䊮⢽⾰᛫૕∝୥⟲䈱∛ᘒ䈮㊀ⷐ䈭㑐ਈ䉕䈚䈩䈇䉎น⢻ᕈ䈏䈅䉎䇯ᚒ䇱䈲䇮trophoblast ਄䈱 CD1d 䉕੺䈚䈢E2GPIଐሽᕈ aPL 䈮䉋䉎ᵹ↥䊜䉦䊆䉵䊛䉕⸃᣿䈜䉎䈖䈫䉕⋡⊛䈫䈚䇮ᤓᐕᐲ䉁䈪䈱⎇ⓥ䈮䈍䈇䈩䇮CD1d 䉕ᕡᏱ⊛䈮⊒⃻䈜䉎 trophoblast ᩣ Jeg3/CD1d 䈱⴫㕙䈮䈍䈇䈩䇮CD1d ⊒⃻䈮৻⥌䈚䈩 PS䇮E 2GPI 䈏ሽ࿷䈚䈩䈇䉎䈖䈫䇮䉁䈢䇮᛫ CD1d ᛫૕䈮ട䈋䇮᛫E2GPI ᛫૕ᷝട䈪䉅᨞ᯅ෻ᔕ䈮䉋䉎 IL-12 䈱⊒⃻䈏⹺䉄䉌䉏䇮᛫E 2GPI ᛫૕䈏䇮PS-E 2GPI ⶄว૕䈫⚿ว䈚䈢 trophoblast ⴫㕙䈱 CD1d 䈫㑆ធ⊛䈮⚿ว䈚䇮䈠䈱⋧੕૞↪䈮䉋䈦䈩 CD1d 䈱᨞ᯅ෻ᔕ䈏⿠䈖䉍䇮CD1d 䉕⊒⃻䈜䉎 trophoblast 䈎䉌䈱 IL-12⺃ዉ䈏⿠䈖䉎䈖䈫䉕᣿䉌䈎䈮䈚䈢䇯䈖䈱᨞ᯅ෻ᔕ䈲䇮
E 2GPI ଐሽᕈ᛫ cardiolipin ᛫૕㓁ᕈਇ⢒∝䈱ᖚ⠪ⴊᷡ䉕 Jeg3/CD1d ၭ㙃♽䈮ᷝട䈚䈩䉅⺃ዉ䈘䉏䈢䇯䈘䉌䈮䇮䊐䊨䊷䉰䉟䊃䊜䊃䊥䊷ᴺ䈮䉋䉎⸃ᨆ䈪䇮䊍䊃⣕⪭ ⤑ 䊥 䊮 䊌 ⃿ 䈮 ኻ 䈜 䉎 DGalCer ೝ ỗ 䈮 䉋 䉍
VD24VE11 㓁ᕈ䈱⣕⪭⤑ iNKT ⚦⢩ᢙ䈏Ⴧട䈜䉎䈖䈫䉕⏕⹺䈚䇮䈖䈱⚦⢩䈫 Jeg3/CD1d 䈫䈱౒ၭ㙃䈪
Jeg3/CD1d 䈎䉌 IL12 䈏⺃ዉ䈏⏕⹺䈘䉏䉎䈖䈫䉕⏕⹺䈚䈢䇯䈚䈎䈚䇮⣕⪭⤑ iNKT ⚦⢩䈎䉌䈱 IL4䇮
IFN-J⺃ዉ䈲⏕⹺䈪䈐䈭䈎䈦䈢䇯ᧄᐕᐲ䈲䇮ᦨ⚳ᐕᐲ䈱⎇ⓥ䈫䈚䈩䇮trophoblast਄䈱 CD1d 䈫⣕⪭⤑ iNKT 䈫䈱⋧੕૞↪䈏䇮᛫E136᛫૕䈱ሽ࿷䈮䉋䉍䇮䈬䈱䉋䈉䈮ᄌൻ䈚䇮ዪᚲ䈮䈍䈔䉎ᅧᆼ఺∉෻ᔕ䈏䈬䈱䉋䈉䈭ᓇ㗀䉕ᬌ⸛䈜䉎䈖䈫䈫䈚䇮᛫䊥䊮⢽⾰᛫૕䈮䉋䉎ᵹ↥⊒∝ᯏᐨ䉕᣿䉌䈎䈮䈜䉎䈖䈫䉕⋡⊛䈫䈚䈢䇯

2GPI䌂䋮⎇ⓥᣇᴺ
1. ੱᎿਛ⛘∝଀䈎䉌ណข䈚䈢䊍䊃⣕⪭⤑䊥䊮䊌⃿䉕 iNKT ⺃ዉ೷DGalCer 䈪ೝỗ䈚䇮iNKT ⚦⢩ rich 䈭⣕⪭⤑䊥䊮䊌⃿䉕⺃ዉ䈚䈢䇯
2. 䈖䈱⣕⪭⤑䊥䊮䊌⃿䉕 Jeg3/CD1d䇮CD1d 䈫⚦⢩ᄖ䊄䊜䉟䊮䈏౒ㅢ䈪⚦⢩ౝ䉲䉫䊅䊦વ㆐䈏⿠ 䈖 䉌 䈭 䈇 䉨 䊜 䊤 ಽ ሶ CD1d/a 䉕 ⊒ ⃻ 䈜 䉎
JEG3/CD1d/a䇮䉅䈚䈒䈲 Jeg3 䈫౒ၭ㙃䈚䇮䈖䈱ၭ㙃♽䈮᛫E 2GPI ᛫૕䉁䈢䈲䉮䊮䊃䊨䊷䊦
IgG 䉕ᷝട䈚䈢䇯
4. Il-12䇮Interferon (IFN)-J⺃ዉ䉕 ELISA ᴺ䈪ⷰኤ䈚䈢䇯(୶ℂ㕙䈻䈱㈩ᘦ)⥃ᐥᬌ૕䈱ណข䇮૶↪䈲䇮ᣉ⸳୶ℂᆔຬળ䈱ᛚ⹺䈱䉅䈫䇮䉟䊮䊐䉤䊷䊛䊄䊶䉮䊮䉶䊮䊃䉕ขᓧ䈚䈩䇮ታᣉ䈚䈢䇯䌃䋮⎇ⓥ⚿ᨐ
1. JEG/CD1d ⚦⢩䈪䈲䇮18 ᤨ㑆ᓟ䈮᛫E2GPI ᛫૕ᷝട⟲䈱 IL12 ↥↢䈏㒶ᕈ䉮䊮䊃䊨䊷䊦 IgGᷝട⟲䈱 3 ୚䈮䉁䈪᦭ᗧ䈮Ⴧട䈚䈢䇯JEG 䉇
JRG/CD1d/a 䈪䈲᛫E2GPI ᛫૕ሽ࿷ਅ䈪䉅䇮
IL12 ↥↢䈱Ⴧട䉕⹺䉄䈭䈎䈦䈢䇯
2. IFN-J䈱↥↢䈮䈧䈇䈩䉅䇮᛫E2GPI ᛫૕ᷝട⟲䈫㒶ᕈ䉮䊮䊃䊨䊷䊦 IgG ᷝട⟲䈱Ყ䉕䈫䉍ฦ⚦⢩㑆䈪Ყセ䈚䈢䇯IL12 䈫⇣䈭䉍ో䈩䈱⚦⢩䈱᛫
E2GPI ᛫૕ᷝട⟲䈪䇮18 ᤨ㑆ᓟ䈮 IFN-J䈱↥↢䈏Ⴧട䈜䉎௑ะ䈮䈅䈦䈢䈏䇮JEG/CD1d ⚦⢩䈮䈍䈇䈩䈱䉂᦭ᗧᏅ䉕⹺䉄䈢䇯䌄䋮⠨ኤᲣ૕䈱⣕⪭⤑⚵❱䈮⢝ఽ䈱 EVT 䈏ㆡಾ䈮ᶐẢ䈚䈩䈇䈒䈖䈫䈏䇮⢝⋚ᒻᚑ䈏ᱜ䈚䈒ⴕ䉒䉏䉎㎛䈫䈭䉎䈏䇮䈖䈱ㆊ⒟䈪䈲ዪᚲ䈪෩ኒ䈮䉮䊮䊃䊨䊷䊦䈘䉏䈢Ἳ∝෻ᔕ䈏ᔅⷐ䈪䈅䉎䇯⣕⪭⤑ iNKT 䈫EVT ਄䈱 CD1d 䈱⋧੕૞↪䈮䉋䉍↥↢䈘䉏䉎IL-12 䈲䈖䈱Ἳ∝෻ᔕ䈮ነਈ䈚䈩䈇䉎䈫⠨䈋䉌䉏䉎䇯䈚䈎䈚䇮䈖䈱Უ૕⢝ఽႺ⇇䈮᛫E2GPI ᛫૕䈏ሽ࿷䈜䉎䈫෩ኒ䈮䉮䊮䊃䊨䊷䊦䈘䉏䈢ⅣႺ䈏ੂ䈘䉏䉎䇯ᧄ⎇ⓥ䈮䈍䈇䈩䇮᛫E2GPI ᛫૕䈏ሽ࿷䈜

䉎䈫䇮PS-E2GPI ⶄว૕䉕੺䈚䈩 CD1d ಽሶ䈏᨞ᯅ䈘䉏䇮IL12 ↥↢䈏Ⴧട䈜䉎䈫䈫䉅䈮䇮CD1d-⣕⪭⤑䊥䊮䊌⃿㑆䈱⋧੕૞↪䈮䉋䉎 IL12 ↥↢䈏䈘䉌䈮ೝỗ䈘䉏䉎䈖䈫䈏␜䈘䉏䈢䇯䉁䈢․䈮 CD1d⊒⃻⚦⢩䈫⣕⪭⤑䊥䊮䊌⃿䈱ធ䈜䉎⢝ఽᲣ૕Ⴚ⇇䈪䈲᛫E2GPI ᛫૕ሽ࿷ਅ䈪 IFN-J↥↢䈏Ⴧട䈜䉎䈖䈫䈏䉒䈎䈦䈢䇯䈜䈭䉒䈤䇮᛫E2GPI ᛫૕䈏ሽ࿷䈜䉎䈫䇮᛫E2GPI ᛫૕䈮䉋䉎 CD1d 䈱᨞ᯅ෻ᔕ䈪↥↢䈘䉏䈢 IL12 䈏Უ૕ IFN-J↥↢⚦⢩
䈪䈅䉎 iNKT ⚦⢩䉕ᵴᕈൻ䈘䈞䇮iNKT ⚦⢩䈎䉌䈱ಽᴲ䈏Ⴧട䈚䈢 IFN-J䈏 trophoblast ਄䈱
CD1d ⊒⃻䉕Ⴧട䈘䈞䈩䇮䈘䉌䈮 CD1d ⊒⃻⚦⢩
䈎䉌䈱 IL12 ಽᴲ䉕ଦㅴ䈜䉎䈫䈇䈉䉰䉟䉪䊦䈏ᔅⷐએ਄䈮ᵴᕈൻ䈘䉏䉎䈖䈫䈏␜䈘䉏䈢䇯䈖䉏䈮䉋䉍䇮Უ૕⢝ఽႺ⇇䈮䈍䈔䉎ዪᚲ䈱Ἳ∝䈏ㆊ೾䈫䈭䉍䇮ᵹ↥䉕ᒁ䈐⿠䈖䈜䈖䈫䈏␜ໂ䈘䉏䈢䇯䌅䋮⚿⺰᛫ E2GPI ᛫ ૕ 䈮 䉋 䉎 ᵹ ↥ 䈏 䇮 ⛐ Ძ ⚦ ⢩ ਄ 䈱
CD1d 䈫⣕⪭⤑ iNKT ⚦⢩䉕੺䈚䈢ㆊ೾䈭Ἳ∝䈮䉋䉎䈫䈇䈉ᣂ䈚䈇ᵹ↥ᯏᐨ䈏␜䈘䉏䈢䇯䌆䋮ஜᐽෂ㒾ᖱႎ㩷 㩷 ⹥ᒰ䈭䈚䌇䋮⎇ⓥ⊒⴫ ⺰ᢥ⊒⴫㩷 ᛩⓂਛ ቇળ⊒⴫㩷 䈭䈚㩷㩷䌈䋮⍮⊛⽷↥ᮭ䈱಴㗿䊶⊓㍳⁁ᴫ䋨੍ቯ䉕฽䉃䇯䋩 ․⸵ขᓧ䈭䈚 ታ↪ᣂ᩺⊓㍳䈭䈚 䈠䈱ઁ䈭䈚㩷137