ෘ↢ഭ௛⑼ቇ⎇ⓥ⾌⵬ഥ㊄㧔ሶߤ߽ኅᐸ✚ว⎇ⓥ੐ᬺ㧕ಽᜂ⎇ⓥႎ๔ᦠಽᜂ⺖㗴㧦ਇ⢒∝ߦଥࠊࠆㆮવⷐ࿃‫ޔ‬ⅣႺⷐ࿃෸߮ߘࠇࠄߩ੤੕૞↪
⎇ⓥಽᜂ⠪  ૒↰ ᢥብ  ࿖┙଻ஜක≮⑼ቇ㒮∉ቇㇱ ␠ળ∉ቇቶ㐳ጊ↰ ⑲ੱ  ␹ᚭᄢቇᄢቇ㒮කቇ⎇ⓥ⑼↥⑼ᇚੱ⑼ቇ⻠ᐳ ᢎ᝼⎇ⓥⷐᣦ ේ࿃ਇ᣿ߩਇ⢒∝ߪ‫৻ޔ‬⒳ߩ↢ᵴ⠌ᘠ∛ߣߺߥߐࠇ‫ޔ‬ㆮવⷐ࿃ߦⅣႺⷐ࿃߇ടࠊࠅ‫ޔ‬੤੕ߦᓇ㗀ߒว߁ߎߣߦࠃࠅ⊒∝ߔࠆ߽ߩߣ⠨߃ࠄࠇߡ޿ࠆ‫ޕ‬ⅣႺⷐ࿃ࠍ⹏ଔߒࠃ߁ߣߔࠆ
႐ว‫ޔ‬੤⛊ⷐ࿃ࠍࠦࡦ࠻ࡠ࡯࡞ߔࠆߩ߇㔍ߒߊ‫ޔ‬ᱜ⏕ߥᦑ㔺㊂ࠍ⹏ଔߒߚ࠺࡯࠲ࠍขࠆߎ
ߣ߇࿎㔍ߢ޽ࠆߚ߼‫⚿ߚߒ⥌৻ޔ‬ᨐߪᓧࠄࠇߡ޿ߥ޿‫ޔࠄ߇ߥߒ߆ߒޕ‬༛ᾍ‫᦯ࡦࠗࠞࠦޔ‬↪‫ޔ‬ਛ╬ᐲߩ㘶㈬‫ࡦࠗࠚࡈࠞޔ‬៨ข‫ޔ‬⢈ḩߪਇ⢒∝ߣ㑐ㅪ߇޽ࠆߣ޿߁ႎ๔߇޽ࠆ‫⎇ᧄޕ‬ⓥߢߪ‫ޔ‬ᅧᇚߩ↢ᵴ⠌ᘠ‫ޔ‬ዬ૑ⅣႺ‫ⷐࠬ࡟࠻ࠬޔ‬࿃╬ߩⅣႺⷐ࿃෸߮⇣‛࡮ࠬ࠹ࡠࠗ࠼ઍ⻢╬ߩߎࠇ߹ߢߦᅧᆼࠕ࠙࠻ࠞࡓߦᓇ㗀ࠍ෸߷ߔߣႎ๔ߩ޽ࠆㆮવሶᄙဳߣਇ⢒∝ߣߩ㑐ㅪࠍ∝଀ኻᾖ⎇ⓥߩᒻߢᬌ⸛ߒߚ‫ޕ‬2001㨪2006 ᐕߦർᶏ㆏ᄢቇ∛㒮↥⑼ߩਇ⢒∝ᄖ᧪ࠍฃ⸻ߒߚᅚᕈ㧔n=204㧕ߣ↥ᓟᄖ᧪ࠍฃ⸻ߒ‫ޔ‬ᵹ↥‫ޔ‬ሶችౝ⤑∝‫ޔ‬ሶች⣼╭∝‫ޔ‬ሶችౝ⊒⢒ㆃᑧ╬ߩᣢᓔߩߥ޿ஜᏱ⚻↥ᇚ㧔n=383㧕ߦኻߒ‫↢ޔ‬ᵴ⠌ᘠ‫ޔ‬ዬ૑ⅣႺ‫ߦ╬ࠬ࡟࠻ࠬޔ‬㑐ߔࠆ⾰໧⚕⺞ᩏࠍታᣉߒ‫⇣⑼↥ޔ‬Ᏹߣ㑐ㅪ߇޽ࠆߣႎ๔ߩ޽ࠆ㧡⒳㘃ߩ৻Ⴎၮᄙဳ㧔SNPs㧕‫ޔ‬හߜ CYP1A1 ㆮવሶ rs4646903 (3698T>C)‫ޔ‬GSTP1 ㆮવሶ rs1695 (I105V)‫ޔ‬COMT ㆮવሶ rs4680(V158M)‫ޔ‬NQO1 ㆮવሶ rs1800566 (P187S)෸߮ PAPPA ㆮવሶ rs7020782 (Y1224S)ࠍ allelicdiscrimination (TaqMan) assay ߦࠃࠅ‫ޔ‬ㆮવሶဳࠍ⸃ᨆߒߚ‫ޕ‬༛ᾍ࡮㘶㈬⠌ᘠࠍ⠨ᘦߒߥ޿႐
วߦߪ‫ޔ‬CYP1A1 ㆮવሶ rs4646903 ߩ CC ဳߦ߅޿ߡ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢ߇⚂ 2.8 ୚਄᣹ߒ‫ޔ‬COMT ㆮવሶ rs4680 ߩ AA ဳߦ߅޿ߡ‫ޔ‬ਇ⢒∝࡝ࠬࠢߪ‫ ⚂ޔ‬0.4 ୚ߦૐਅߒߚ‫ޕ‬༛ᾍ⠌ᘠࠍ⠨ᘦߔࠆߣ‫ޔ‬CYP1A1 ㆮવሶ rs4646903 ߦ߅޿ߡ‫ޔ‬㕖༛ᾍ⟲ߩ TT ဳߦᲧߴ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢ߇‫ޔ‬༛ᾍ⟲ߩ CC ဳߢߪ‫ ⚂ޔ‬6.1 ୚਄᣹ߒߚ‫⎇ᧄޕ‬ⓥߦࠃࠅ‫ޔ‬ਇ⢒∝ߦ߅޿ߡ߽‫ޔ‬ㆮવሶ́ⅣႺ⋧੕૞↪ߦࠃࠅ∔ᖚ࡝ࠬࠢ߇਄᣹ߔࠆߎߣ߇␜ໂߐࠇߚ‫ޕ‬㧭㧚⎇ⓥ⋡⊛ ਇ⢒∝ߩ∛࿃ߣߒߡߪ‫ޔ‬ォᐳ߿ሶችᒻᘒ⇣Ᏹߩࠃ߁ߥේ࿃ߩ᣿⊕ߥ߽ߩࠍ㒰ߌ߫‫৻ޔ‬⒳ߩ↢ᵴ⠌ᘠ∛ߣߺߥߐࠇ‫ޔ‬ㆮવⷐ࿃ߦⅣႺⷐ࿃߇ടࠊࠅ‫ޔ‬੤੕ߦᓇ㗀ߒว߁ߎߣߦࠃࠅ⊒∝ߔࠆ߽ߩߣ⠨߃ࠄࠇߡ޿ࠆ‫ޕ‬ⅣႺⷐ࿃ߣߒߡߪ‫ޔ‬㘩੐࡮↢ᵴ⠌ᘠ‫ޔ‬ዬ૑ⅣႺ߅ࠃ߮ࠬ࠻࡟ࠬⷐ࿃ߥߤ߇ਇ⢒∝ߩ࡝ࠬࠢߦ㑐ਈߔࠆߎߣߦ㑐ᔃ߇ᜬߚࠇߡ޿ࠆ‫ࠃߩߎޕ‬߁ߥⅣႺⷐ࿃ࠍ⹏ଔߒࠃ߁ߣߔࠆ႐ว‫ޔ‬੤⛊ⷐ࿃ࠍࠦࡦ࠻ࡠ࡯࡞ߔࠆߩ߇㔍ߒߊ‫ޔ‬ᱜ⏕ߥᦑ㔺㊂ࠍ⹏ଔߒߚ࠺࡯࠲ࠍขࠆߎߣ߇࿎㔍ߢ޽ࠆߚ߼‫৻ޔ‬⥌ߒߚ⚿ᨐߪᓧࠄࠇߡ޿ߥ޿㧔1㧕‫ޔࠄ߇ߥߒ߆ߒޕ‬޿ߊߟ߆ߩⅣႺⷐ࿃߇ᅧᆼࠕ࠙࠻ࠞࡓߦᓇ㗀ࠍਈ߃ࠆߎߣߪႎ๔ߐࠇߡ߈ߚ㧔1-6㧕‫ޕ‬༛ᾍߪ‫ޔ‬ᩕ㙃⤑ᯏ⢻ߦᖡᓇ㗀ࠍ෸߷ߒ‫ޔ‬㊂ଐሽ⊛ߦਇ⢒∝ߩ࡝ࠬࠢࠍ਄᣹ߐߖࠆ㧔2㧕‫ߪ↪᦯ࡦࠗࠞࠦޕ‬༛ᾍߣߣ߽ߦ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢࠍ਄᣹ߐߖࠆ㧔3㧕‫ޕ‬ਛ╬ᐲߩ㘶㈬ߪ‫ޔ‬ᅧᆼೋᦼߩਇ⢒∝ߩ࡝ࠬࠢࠍ਄᣹ߐߖ
ࠆ㧔4㧕‫ࡦࠗࠚࡈࠞޕ‬៨ข߽㊂ଐሽ⊛ߦਇ⢒∝࡝ࠬࠢߣߩ㑐ㅪ߇⷗ࠄࠇ‫ޔ‬㧝ᣣᒰߚࠅ 300mg એ਄ߩ៨ขߢਇ⢒∝࡝ࠬࠢࠍ᦭ᗧߦ਄᣹ߐߖࠆ㧔5㧕‫ޕ‬BMI
30kg/m2 ࠍ⿥߃ࠆ⢈ḩߪ‫ޔ‬ᅧᆼೋᦼߩᵹ↥‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢࠍ਄᣹ߐߖࠆ㧔6㧕‫⎇ᧄޕ‬ⓥߢߪ‫↢ޔ‬ᵴ⠌ᘠ‫ޔ‬ዬ૑ⅣႺ߅ࠃ߮ࠬ࠻࡟ࠬⷐ࿃╬ߩⅣႺⷐ࿃෸߮⇣‛࡮ࠬ࠹ࡠࠗ࠼ઍ⻢╬ߩߎࠇ߹ߢߦᅧᆼࠕ࠙࠻ࠞࡓߦᓇ㗀ࠍ෸߷ߔߣႎ๔ߩ޽ࠆㆮવሶᄙဳ߇‫ޔ‬ਇ⢒∝ߦ෸߷ߔᓇ㗀߿⋧੕૞↪ࠍ᣿ࠄ߆ߦߔࠆߎߣࠍ⋡⊛ߦታᣉߒߚ‫ޕ‬B㧚⎇ⓥᣇᴺ 2001㨪2006 ᐕߦർᶏ㆏ᄢቇ∛㒮↥⑼ߩਇ⢒∝ᄖ᧪ࠍฃ⸻ߒߚᅚᕈ㧔n=204㧕ߣ↥ᓟᄖ᧪ࠍฃ⸻ߒ‫ޔ‬ᵹ↥‫ޔ‬ሶችౝ⤑∝‫ޔ‬ሶች⣼╭∝‫ޔ‬ሶችౝ⊒⢒ㆃᑧ╬ߩᣢᓔߩߥ޿ஜᏱ⚻↥ᇚ㧔n=383㧕ߦኻߒ‫ޔ‬㘩੐࡮

165↢ᵴ⠌ᘠ‫ޔ‬ዬ૑ⅣႺ‫ޔ‬⡯ᬺ‫ޔ‬ᅧᆼೋᦼߩஜᐽ⁁ᘒ‫ޔ‬↥⑼ᣢᓔᱧ‫ߣࠬ࡟࠻ࠬޔ‬㑐ㅪߒߚ⁁ᘒ-․ᕈਇ቟
㧔STAI㧕ߦ㑐ߔࠆ⾰໧⚕⺞ᩏࠍታᣉߒ‫ޔ‬ណⴊࠍⴕߞߚ‫ߦࠬ࡟࠻ࠬޕ‬ኻߔࠆਇ቟ࠍ␜ߔ⁁ᘒዤᐲ
㧔A-State㧕ߩᓧὐ‫ޔ‬Ყセ⊛቟ቯߒߚ୘ੱౝ․ᕈࠍ
␜ߔ․ᕈዤᐲ㧔A-Trait㧕ߩᓧὐࠍ▚಴ߒ‫⟲଀∝ޔ‬ߣኻᾖ⟲ߩᐔဋ୯‫ޔ‬ᮡḰ஍Ꮕࠍ᳞߼ߚ‫ޕ‬ዬ૑ⅣႺ
ߦ㑐ߒߡߪ‫⸳ޔ‬໧Ფߦ∝଀⟲‫ޔ‬ኻᾖ⟲ߩഀวࠍ᳞
߼ߚ‫́଀∝ޕ‬ኻᾖ⟲㑆ߩᐔဋ୯ߩᏅࠍኻᔕߩߥ޿㨠ᬌቯߦࠃࠅ‫ޔ‬Ყ₸ࠍ 2 ᬌቯߦࠃࠅ⸃ᨆߒߚ‫߹ޕ‬ߚ‫⇣⑼↥ޔ‬Ᏹߣ㑐ㅪ߇޽ࠆߣႎ๔ߩ޽ࠆ㧡⒳㘃ߩ৻Ⴎၮᄙဳ㧔SNPs㧕‫ޔ‬හߜ CYP1A1 ㆮવሶ rs4646903(3698T>C)‫ޔ‬GSTP1 ㆮવሶ rs1695 (I105V)‫ ޔ‬COMT
ㆮવሶ rs4680 (V158M)‫ޔ‬NQO1 ㆮવሶ rs1800566(P187S)෸߮ PAPPA ㆮવሶ rs7020782 (Y1224S)ࠍ
allelic discrimination (TaqMan) assay ߦࠃࠅ‫ޔ‬ㆮવሶဳࠍ⸃ᨆߒߚ‫ޕ‬ਇ⢒∝ࠍࠕ࠙࠻ࠞࡓߣߒߡ‫ޔ‬Უⷫߩᐕ㦂ߢ⺞ᢛߒߚࡠࠫࠬ࠹ࠖ࠶ࠢ࿁Ꮻಽᨆߦࠃࠅ‫ޔ‬ࠝ࠶࠭Ყߣ 95㧑ା㗬඙㑆ࠍ᳞߼ߚ‫⸃⸘⛔ޕ‬ᨆߦߪ
SPSS 17.0 ࠍ↪޿ߚ‫ޕ‬㧔୶ℂ㕙߳ߩ㈩ᘦ㧕ᧄ⎇ⓥߪർᶏ㆏ᄢቇᄢቇ㒮කቇ⎇ⓥ⑼කߩ୶ℂᆔຬળߦ߅޿ߡᛚ⹺ߩ߁߃ታᣉߒߚ‫࡯ࠜࡈࡦࠗޕ‬ࡓ࠼ࠦࡦ࠮ࡦ࠻ߪ‫∉ޟ‬ቇ⎇ⓥߦ㑐ߔࠆ୶ℂᜰ㊎‫ޔޠ‬‫࡮ࡓࡁࠥ࠻ࡅޟ‬ㆮવሶ⸃ᨆ⎇ⓥߦ㑐ߔࠆ୶ℂᜰ㊎‫ޠ‬߅ࠃ߮ࡋ࡞ࠪࡦࠠት⸒ߦၮߠ޿ߡⴕߞߚ‫⎇ޕ‬ⓥ߳
ߩෳടߪ⥄↱ᗧᔒߦࠃࠅ‫ߦ⊛⊒⥄ޔ‬ਛᱛߒߡ߽ਇ೑⋉ࠍⵍࠄߥ޿ࠃ߁㈩ᘦߒߚ‫ޕ‬ኻ⽎⠪ߩࡊ࡜ࠗࡃࠪ࡯ߩ଻ᜬߦߪ⚦ᔃߩᵈᗧࠍᛄߞߚ‫ޕ‬એ਄ߩࠃ߁ߦ‫⎇ᧄޔ‬ⓥߪ‫୶ޔ‬ℂ㕙ߩචಽߥ㈩ᘦߩ߁߃ⴕߞߚ‫ޕ‬C㧚⎇ⓥ⚿ᨐ
∝଀⟲ߩ A-State ߩᐔဋᓧὐ㧔SD㧕ߪ‫ޔ‬39.4㧔10.1㧕‫ޔ‬ኻᾖ⟲ߩᐔဋᓧὐ㧔SD㧕ߪ‫ޔ‬38.5㧔9.5㧕‫⟲଀∝ޔ‬ߩ A-Trait ߩᐔဋᓧὐ㧔SD㧕ߪ‫ޔ‬42.9㧔9.6㧕‫ޔ‬ኻᾖ⟲ߩᐔဋᓧὐ㧔SD㧕ߪ‫ޔ‬41.9㧔9.8㧕ߢ޽ࠅ‫ߕ޿ޔ‬ࠇ߽∝଀⟲߇⧯ᐓ㜞୯ࠍ␜ߒߚ߇‫⸘⛔ޔ‬ቇ⊛ߦߪ᦭ᗧߢߪߥ߆ߞߚ㧔࿑㧝㧕‫ޕ‬༛ᾍ࡮㘶㈬ߩ↢ᵴ⠌ᘠ߿ዬ૑ⅣႺߣߩ⋧੕૞↪߽ߺࠄࠇߥ߆ߞߚ‫ޕ‬ዬ૑ⅣႺߦ㑐ߒߡߪ‫(ޔ‬1) ⃻࿷ߩዬ૑࿾‫(ޔ‬2) ૑ቛߩ㓏ᢙ‫(ޔ‬3) ᑄ᫈‛㧔ߏߺ㧕ಣℂᣉ⸳߆ࠄߩ〒㔌‫ޔ‬(4) ⵾⚕Ꮏ႐߆ࠄߩ〒㔌෸߮ (5) ᐙ✢㆏〝㧔 ㆏㧞ゞ✢એ਄㧕ࠄߩ〒㔌ߦ㑐ߒߡ‫ߣ⟲଀∝ޔ‬ኻᾖ⟲ߩ㗫ᐲᏅࠍᲧセߒߚ߇‫᦭߽ࠇߕ޿ޔ‬ᗧߢߪߥ߆ߞߚ㧔࿑㧞㧕‫ޕ‬༛ᾍ࡮㘶㈬⠌ᘠࠍ⠨ᘦߒߥ޿႐วߦߪ‫ޔ‬ฦ SNP166ߦ߅ߌࠆㆮવሶဳߩࠝ࠶࠭Ყࠍ࿑㧟ߦ␜ߔ‫ޕ‬CYP1A1 ㆮવሶ rs4646903 ߩ CC ဳߦ߅޿ߡ‫ޔ‬ਇ⢒∝ ߩ ࡝ ࠬ ࠢ ߇ ⚂ 2.8 ୚ ਄ ᣹ ߒ 㧔 95% ା 㗬 ඙ 㑆
1.5-5.4㧕‫ޔ‬PAPPA ㆮવሶ rs7020782 ߩ CC ဳߢシᐲ਄᣹௑ะ߇⹺߼ࠄࠇߚ㧔ࠝ࠶࠭Ყ 1.7‫ޔ‬95%ା㗬඙㑆 0.6-4.4㧕‫৻ޕ‬ᣇ‫ޔ‬COMT ㆮવሶ rs4680 ߩ AA ဳߦ߅޿ߡ‫ޔ‬ਇ⢒∝࡝ࠬࠢߪ‫ ⚂ޔ‬0.4 ୚ߦૐਅߒߚ
㧔95%ା㗬඙㑆 0.1-1.0㧕‫ޕ‬༛ᾍ࡮㘶㈬⠌ᘠࠍ⠨ᘦߔࠆߣ‫ޔ‬CYP1A1 ㆮવሶ rs4646903 ߦ߅޿ߡ‫ޔ‬㕖༛ᾍ⟲ߩ TT ဳߦᲧߴ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢ߇‫ޔ‬㕖༛ᾍ⟲ߩ CC ဳߢߪ‫ ⚂ޔ‬2.4 ୚㧔95%ା㗬඙㑆 1.1-5.2㧕‫ޔ‬ߐࠄߦ༛ᾍ⟲ߩ CC ဳߢߪ‫ ⚂ޔ‬6.1 ୚㧔95%ା㗬඙㑆 1.3-28.6㧕਄᣹ߒߚ㧔࿑㧠㧕‫৻ޕ‬ᣇ‫ޔ‬㕖㘶㈬⟲ߩTT ဳߦᲧߴ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢ߇‫ޔ‬㕖㘶㈬⟲ߩ CCဳߢߪ‫ ⚂ޔ‬2.9 ୚㧔95%ା㗬඙㑆 1.2-6.7㧕‫ޔ‬㘶㈬⟲ߩ CC ဳߢߪ‫ ⚂ޔ‬2.4 ୚㧔95%ା㗬඙㑆 0.7-3.7㧕਄᣹ߒߚ߇‫ޔ‬ᓟ⠪ߪ᦭ᗧߢߪߥ߆ߞߚ㧔࿑㧡㧕‫ઁޕ‬ߩ SNP ߦ߅޿ߡߪ‫ޔ‬༛ᾍ࡮㘶㈬⠌ᘠࠍ⠨ᘦߒߡ߽‫ޔ‬᦭ᗧߥ࡝ࠬࠢߩᄌൻߪ⹺߼ࠄࠇߥ߆ߞߚ‫ޕ‬D㧚⠨ኤ ᵹ↥ߪ‫ޔ‬ਇ቟‫ޔ‬ᛥ߁ߟ‫ޔ⹺ุޔ‬ᔶࠅ‫ޔ‬ᄦᇚ㑐ଥߩ፣უ‫ޔ‬༚ᄬᗵ‫ޔ‬ਇචಽߥߤߩ㗼⪺ߥᖱ✜⊛ߥ෻ᔕࠍᒁ߈⿠ߎߒᓧࠆ㧔1㧕‫ޕ‬᭽‫ߥޘ‬ᔃℂ␠ળⷐ࿃߇
఺∉♽ߦᓇ㗀ࠍ෸߷ߒ‫␹♖̌ࠆࠁࠊ޿ޔ‬-␹⚻-఺∉-ౝಽᴲࡀ࠶࠻ࡢ࡯ࠢ̍߇ᵹ↥ߦ㑐ਈߔࠆߎߣ߇ឭ
໒ߐࠇߡ޿ࠆ㧔7,8㧕‫ޔߚ߹ޕ‬ਇ⢒∝଀ߦ߅޿ߡ‫ޔ‬ᛥ߁ߟ⁁ᘒ߇ᵹ↥ࠍᒁ߈⿠ߎߒᓧࠆⷐ࿃ߩ৻ߟߢ
޽ࠆߎߣ߇␜ໂߐࠇߡ޿ࠆ㧔9㧕‫⷗ߥ߁ࠃߩߎޕ‬࿾߆ࠄ‫⎇ᧄޔ‬ⓥߢߪ‫⁁ޔ‬ᘒ-․ᕈਇ቟㧔STAI㧕ࠍ↪޿‫ޔ‬ਇ⢒∝଀⟲ߣኻᾖ⟲ߣߩ㑆ߩࠬ࠻࡟ࠬߦኻߔࠆਇ
቟ࠍ␜ߔ⁁ᘒዤᐲ㧔A-State㧕‫ޔ‬Ყセ⊛቟ቯߒߚ୘ੱ
ౝ․ᕈࠍ␜ߔ․ᕈዤᐲ㧔A-Trait㧕ࠍᲧセߒߚ߇‫ޔ‬᦭ᗧᏅߪ⹺߼ࠄࠇߕ‫ޔ‬༛ᾍ࡮㘶㈬⠌ᘠ‫ޔ‬ዬ૑ⅣႺ෸߮ฦㆮવሶဳߣߩ⋧੕૞↪߽⹺߼ࠄࠇߥ߆ߞߚ‫ޕ‬৻ᣇ‫࠼ࠗࡠ࠹ࠬ࡮‛⇣ޔ‬ઍ⻢╬ߩߎࠇ߹ߢߦᅧᆼࠕ࠙࠻ࠞࡓߦᓇ㗀ࠍ෸߷ߔߣႎ๔ߩ޽ࠆㆮવሶᄙဳߩ߁ߜ‫ޔ‬CYP1A1 ㆮવሶ rs4646903 ߦ߅޿ߡ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢߩ਄᣹߇⹺߼ࠄࠇ‫ޔ‬༛ᾍߦࠃࠅჇᒝ ߔ ࠆ ߎ ߣ ߇ ⷰ ኤ ߐ ࠇ ߚ ‫ ޕ‬CYP1A1 ㆮ વ ሶrs4646903 ߩᄌ⇣ࠕ࡝࡞ߪ‫ޔ‬⢖߇ࠎ╬ߩᖡᕈ⣲≌ߩ࡝ࠬࠢࠍ㜞߼ࠆߎߣ߇⍮ࠄࠇߡ߅ࠅ㧔10㧕‫ޔ‬ਇ⢒∝߿ૐ಴↢૕㊀╬ߩᅧᆼࠕ࠙࠻ࠞࡓߦᓇ㗀ࠍ෸߷ߔߎߣ߇⍮ࠄࠇߡ޿ࠆ㧔11-14㧕‫ޔߚ߹ޕ‬༛ᾍߣߩ⋧੕૞↪ߦࠃࠅ‫∔ޔ‬ᖚ࡝ࠬࠢ߇Ⴧᒝߔࠆߎߣ߇ႎ๔
ߐࠇߡ޿ࠆ㧔11,14㧕
‫ޕ‬CYP1A1 ߩᵴᕈߩ㜞޿ᄌ⇣ࠕ࡝࡞ߦࠃߞߡ‫ޔ‬ᾍ⨲ᾍߦ฽߹ࠇࠆൻቇ‛⾰߆ࠄਇ቟ቯߥઍ⻢↥‛߳ߩ↥↢߇Ⴧടߒ‫⚦ޔ‬⢩ౝߢᲥᕈ߇Ⴧߔߎߣ߇ේ࿃ߣ⠨߃ࠄࠇߡ޿ࠆ‫⎇ᧄޕ‬ⓥߦ߅޿ߡ‫ޔ‬ਇ⢒∝ߦ߅޿ߡ߽‫ߥ߁ࠃߩߎޔ‬ᯏᐨߦࠃࠅ
∔ᖚ࡝ࠬࠢ߇਄᣹ߔࠆߎߣ߇␜ໂߐࠇߚ‫ޕ‬E㧚⚿⺰ᧄ⎇ⓥߢߪ‫ޔ‬CYP1A1 ㆮવሶ rs4646903 ߩ CC ဳߦ߅޿ߡ‫ޔ‬ਇ⢒∝ߩ࡝ࠬࠢ߇⚂ 2.8 ୚਄᣹ߒ‫ޔ‬༛ᾍ߇ടࠊࠆߣ⚂ 6.1 ୚ߦ߽਄᣹ߒߚ‫ޕ‬ਇ⢒∝ߦ߅޿ߡ߽‫ޔ‬ㆮવሶ́ⅣႺ⋧੕૞↪ߦࠃࠅ∔ᖚ࡝ࠬࠢ߇਄᣹ߔࠆߎߣ߇␜ໂߐࠇߚ‫ޕ‬㨇ෳ⠨ᢥ₂㨉
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F㧚ஜᐽෂ㒾ᖱႎ  ․ߦߥߒ
G㧚⎇ⓥ⊒⴫
㧝㧚⺰ᢥ⊒⴫  ߥߒ㧔Ḱ஻ਛ㧕㧞㧚ቇળ⊒⴫
1. Sata F, Yamada H, Nakao H, Minakami H, Kishi
R, Imai H. Lifestyle, physical burden and anxiety
in pregnant women and recurrent pregnancy loss.
21st International Conference of Environmental
Epidemiology, Dublin, Ireland, August 25-29,
2009.
H㧚⍮⊛⽷↥ᮭߩ಴㗿࡮⊓㍳⁁ᴫ  ⹥ᒰߥߒ167

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