Research Subjects
SectionMolecular Cell Biology
and Oral Anatomy

Research Subjects
・Orofacial stem cell-based medicine for tissue/organ
regeneration
・Molecular regulation of proliferation, differentiation,and senescence in orofacial stem cells
・Orofacial stem cell-based pathology for human diseases
・Functions of neural crest-derived stem cells in organ
development
・Molecular mechanism of bone metabolism

Molecular andCellular Biochemistry

・ The common molecular mechanisms that control
postmenopausal osteoporosis and weight gain anddevelopment of therapeutic strategies
・The regulatory mechanism of bone metabolism
・The molecular mechanism of bone invasion by oral cancer

Aging Science andPharmacology

・Studies on type 3 Diabetes and Alzheimer’s Disease・Impacts of chronic systemic inflammation on the brain
functions (especially focus on microglia)
・Pathophysiological roles of cathepsins in inflammation

Oral Neuroscience・Understanding of molecular mechanisms of taste
signaling associated with various diseases (e.g.taste
disorders, metabolic syndromes) and development oftherapeutic methods for the diseases
・Taste organ regeneration and functional analysis oftaste related molecules by using new 3 dimensional organ
culture system (organoid)
・Analysis of taste signaling serving for different
functions in multiple organs
・Analysis of regulation of food intake and energy
homeostasis via taste signaling in oral-brain-gut axis

Oral, Brain and Total
Health Science

・Studies on predisposition to non-communicable diseases
regulated by environmental factors and epigenomic
memory・Studies on molecular basis of biological defense systemregulation mediated by protease reaction
・Studies on the sex differences in energy metabolism andcognitive function

Preventive and Public
Health Dentistry・Molecular epidemiology on relationship between oral
microbiome and oral and systemic health・Epidemiology on relationship between oral and systemichealth・Clinical study of relationship between oral function andsystemic health・Development of preventive measures of oral diseases
utilizing molecular biology

Pediatric Dentistry
and Special NeedDentistry

・Translational research of applying primary tooth toregenerative medicine
・Study of the energy metabolism on craniofacial growthand development
・Molecular analysis of mitochondrial function during
dento-craniofacial morphogenesis and development・Genetic analysis of congenital anomaly of craniofacialcomplex in children and special need children

Orthodontics and
Dentofacial
Orthopedics

・Analysis for the molecular mechanisms throughepithelial-mesenchymal interaction
・Molecular mechanism of the mechanical stress response
during chondrogenesis and osteogenesis
・Molecular and developmental biological analysis of thecraniofacial region
・Finite element analysis and biomechanics relating toclinical orthodontics
・An approach to evaluate the physiological andbiochemical properties of stomatognathic function
・Improvement of Quality of Life through orthodontic
treatment for patient with malocclusion

Biomaterials

・Fabrication of carbonate apatite bone replacement
・Development of three-dimensional interconnected bonereplacement
・Development of osteoconductive polymer
・Development of high performance apatite cement
・Analysis of the mechanism of osteoconductivity

Endodontology andOperative Dentistry

・Studies on identification of factors and scaffolds
indispensable for periodontal ligament tissue regeneration
・Studies on the induction of periodontal ligament stem
cells derived from iPS cells
・Developmental research on ‘Bio-Implant’ which includes
the engineered periodontal ligament tissue・Development of novel pulp capping materials
・Studies on the aging of dental pulp cells
・Development of bactericidal treatment for caries
microorganisms using bacteriophage

Periodontology

・Studies on the development of new assessment anddiagnostic tool for periodontal diseases
・Studies on etiology and bio-regulatory mechanisms of
periodontal disease
・Studies on biological periodontal tissue regeneration
・Basic and clinical studies on the interaction between
periodontal disease and systemic disease
・Studies on the mechanism of development of low-grade
inflammation caused by periodontal disease, and its
influence on other tissues
・Studies on the pathogenesis of unique periodontal
disease such as drug-induced gingival overgrowth・Studies on the elucidation of patho-physiology ofpulpitis and establishment of novel molecular targeted
therapy

Fixed Prosthodontics

・Studies on esthetic prosthesis
・Clinical and physiological study on maxillofacial
rehabilitation
・Longitudinal study of oral functions and prosthetic
interventions
・Evaluation and management of systemic condition andoral functions in the elderly population
・Clinical study on the association between perioral
muscles and oral functions
・Analytical study on treatment planning for prosthetic
interventions
・Clinical research for bone regeneration
・Mechanobiology of dental implant and prosthodontics

Implant andRehabilitative
Dentistry・Development of biomaterials for prosthodontic
treatment
・Mechanobiology of dental implant and prosthodontics
・Studies on bone regeneration therapy
・Epidemiological and physiological study on oral
rehabilitation using removable dentures
・Epidemiological and biomechanical study on oral
rehabilitation using implants
・Application of digital dentistry and workflow acrossprosthodontic treatment
・Studies on physical effect of mouthguard for exercise
・Development and evaluation of treatments in
Medication-Related Osteonecrosis of the Jaw・Studies for optimisation of the surgical andprosthodontic skills affecting short / long term success for
implant treatment

Oral Pathology

・Molecular and genetic investigation on the development
and regeneration of the tooth and periodontal tissues forregenerative therapy
・Cellular and molecular biology of oral cancer
・Investigation of a common mechanism of developmental
formation and tumor formation

Oral and Maxillofacial
Radiology

・Research on quantification of maxillofacial images
・Computer-assisted diagnosis using maxillofacial images
・Studies on digital intraoral imaging system
・Research on the characteristics of dental cone beam CT
・Research on the application of MR and ultrasounddevices to the dental field・Image analysis on oral cancers
・Image analysis on the structure and pathology ofsalivary glands
・Image analysis on the structure and pathology of themasticatory muscles and related structures
・Development of the training system for dental
radiography using virtual reality techniqueOral and MaxillofacialSurgery

・Accurate 3 dimensional measurement on cleft lip andpalate / jaw deformity
・Development of surgical simulation / navigation system
・A study on bone regeneration and compatible
biomaterials
・Development of artificial temporo-mandibular joint
・Development of new treatment method in cleft lip andpalate
・Development and evaluation of treatments in jaw
deformity・Molecularly targeted therapy for oral cancer
・A study on the mechanism of invasion and metastasisof oral cancer
・Molecular mechanisms of salivary gland development
and regeneration
・Immunological studies on the pathogenesis of oral
mucosal diseases
・Immunological studies on the pathogenesis of Sjögren's
syndrome
・Experimental study on bone regeneration in jaw
・A study on regulatory mechanisms of bone immunology

Oral and Maxillofacial
Oncology

・Development of the novel treatment for oral cancer
・Studies on morphological and functional reconstruction
after the surgery of oral cancer
・Studies on host defense mechanism against oral cancer

・Studies on the oncogenes of oral cancer
・Studies on the mechanism of invasion and metastasisof oral cancer
・Studies on the mechanism of the escape from immune
surveillance by tumor-associated macrophages of oralcancer
・Studies on relationship between oral bacterial flora andtreatment of oral cancer
・Studies on dysphagia after treatment of oral cancer(evaluation and rehabilitation)
・An immunological study on the pathogenesis of oral
mucosal diseases
・Analysis of the cell differentiation and intracellulartransduction of oral epithelial cells
・Immunological studies on the pathogenesis of Sjögren'ssyndrome
・Immunological studies on the pathogenesis of IgG4related disease
・Studies on expanded T and B cells for IgG4-RD andother human autoimmune disease -Joint International
Research・Studies on the treatment of odontogenic tumors
・Biological and cytological studies of odontogenic tumors
・Studies on the orthognathic surgery for jaw deformities
・Clinical studies on the preventive treatment of antiresorptive agents related osteonecrosis of the jaw
・Studies on the pathogenesis and treatment of cleft lip
and or palate・Clinical studies on the relationship between chronic
orofacial pain and psychosocial factors

Dental Anesthesiology

・Studies on nutrition and metabolism during
perioperative period
・Studies on life support for dental emergency
・Studies on clinical pharmacokinetics of aspirin・Studies on electroencephalogram during generalanesthesia
・Studies on electrocardiogram during perioperative
period・Studies on the management of tracheal tube during
general anesthesia
・Studies on microcirculation during general anesthesia
・Study of the effect of inspiratory oxygen concentration
during general anesthesia after emergency
・Study on hemolysis by extracorporeal circulation
・Study on the standard values of preoperative screening
tests in children
・Study of AR-based materials on the educational effects

Geriatric Dentistry and ・Studies on the relationship among oral function,
Perioperative
systemic disease, and nutrition
Medicine in Dentistry
・Studies on oral management of patients with systemic
disease・Studies on oral function management for long healthy
lives・Studies on the development of regenerative dental
medicine for super-aged society
・Studies on oral health care for multidisciplinary
collaboration in disastersDental Education

・Development of instructional strategies to encourage
students to transform themselves into lifelong active
learners
・Development of systematic outcome-based educational
programs
・Development of ICT-based learning support systems
and effective learning materials
・Development of reliable tools to assess students'
learning outcomes

General Dentistry

・Studies on oral tissue regeneration using stem cell
populations and/or stem cell-inducing factors
・Studies on oral care for the perioperative patients・Studies on the improvement of oral function for ADL
elevation of the aged.
・Studies on etiology and bacteria of periodontal disease
・Development of novel training programs andevaluation systems for dental trainees
・Research on mental health status of dental trainees